Homology by BLASTX
BLASTX 2.2.4 [Aug-26-2002]
Query= C05A9_3
(3852 letters)
Database: /home/niguts/usr02/tshini/ykclst/db/nr.seq
1,967,186 sequences; 661,712,633 total letters
Score E
Sequences producing significant alignments: (bits) Value
gi|17550138|ref|NP_509810.1| P-GlycoProtein related (pgp-5) [Cae... 2466 0.0
gi|50507726|emb|CAA94219.3| Hypothetical protein T21E8.2 [Caenor... 1682 0.0
gi|17569909|ref|NP_509812.1| P-GlycoProtein related (pgp-7) [Cae... 1676 0.0
gi|39594939|emb|CAE70807.1| Hypothetical protein CBG17569 [Caeno... 1632 0.0
gi|17569907|ref|NP_509813.1| P-GlycoProtein related (pgp-6) [Cae... 1622 0.0
gi|7508148|pir||T25082 hypothetical protein T21E8.2 - Caenorhabd... 1462 0.0
gi|25146777|ref|NP_509811.2| P-GlycoProtein related (pgp-8) [Cae... 1431 0.0
gi|7511495|pir||T18940 multidrug resistance protein homolog - Ca... 1418 0.0
gi|39594940|emb|CAE70808.1| Hypothetical protein CBG17570 [Caeno... 1413 0.0
gi|7508147|pir||T25083 hypothetical protein T21E8.1 - Caenorhabd... 1404 0.0
gi|39594943|emb|CAE70811.1| Hypothetical protein CBG17574 [Caeno... 1079 0.0
gi|39585393|emb|CAE61715.1| Hypothetical protein CBG05664 [Caeno... 890 0.0
gi|17558664|ref|NP_507487.1| P-GlycoProtein related (pgp-9) [Cae... 885 0.0
gi|39587899|emb|CAE67917.1| Hypothetical protein CBG13514 [Caeno... 833 0.0
gi|17541710|ref|NP_502413.1| P-GlycoProtein related (pgp-1) [Cae... 823 0.0
gi|283551|pir||S27337 multidrug resistance protein A - Caenorhab... 823 0.0
gi|39595370|emb|CAE60408.1| Hypothetical protein CBG04013 [Caeno... 800 0.0
gi|17508505|ref|NP_491707.1| P-GlycoProtein related (pgp-2) [Cae... 782 0.0
gi|40644181|emb|CAC86600.1| multidrug resistance protein [Platic... 770 0.0
gi|25297453|pir||D87789 protein C34G6.4 [imported] - Caenorhabdi... 769 0.0
gi|1362689|pir||S55692 multidrug resistance protein homolog (mdr... 765 0.0
gi|833699|gb|AAA75000.1| multidrug resistance protein >gnl|BL_OR... 765 0.0
gi|45382457|ref|NP_990225.1| ABC transporter protein [Gallus gal... 760 0.0
gi|39594783|emb|CAE70651.1| Hypothetical protein CBG17356 [Caeno... 759 0.0
gi|126924|sp|P21448|MDR1_CRIGR Multidrug resistance protein 1 (P... 758 0.0
gi|25453370|ref|NP_036755.2| P-glycoprotein/multidrug resistance... 756 0.0
gi|17569145|ref|NP_509902.1| P-GlycoProtein related (pgp-4) [Cae... 755 0.0
gi|72477|pir||DVHY1C multidrug resistance protein 1 - Chinese ha... 755 0.0
gi|50732589|ref|XP_418707.1| PREDICTED: similar to ATP-binding c... 754 0.0
gi|6755046|ref|NP_035205.1| ATP-binding cassette, sub-family B (... 749 0.0
gi|126928|sp|P21449|MDR2_CRIGR Multidrug resistance protein 2 (P... 746 0.0
gi|38073917|ref|XP_283101.2| similar to multidrug resistance p-g... 746 0.0
gi|25453402|ref|NP_596892.1| ATP-binding cassette, sub-family B ... 745 0.0
gi|46394986|gb|AAS91649.1| multidrug resistance protein 1a; P-gl... 742 0.0
gi|6755048|ref|NP_035206.1| ATP-binding cassette, sub-family B (... 740 0.0
gi|266517|sp|P21447|MDR3_MOUSE Multidrug resistance protein 3 (P... 740 0.0
gi|307180|gb|AAA59575.1| P-glycoprotein [Homo sapiens] 740 0.0
gi|27656757|gb|AAO20901.1| Mdr3 [Takifugu rubripes] 740 0.0
gi|1170902|sp|P43245|MDR1_RAT Multidrug resistance protein 1 (P-... 739 0.0
gi|42741659|ref|NP_000918.2| ATP-binding cassette sub-family B m... 738 0.0
gi|191157|gb|AAA37005.1| p-glycoprotein 738 0.0
gi|2506118|sp|P08183|MDR1_HUMAN Multidrug resistance protein 1 (... 737 0.0
gi|4505771|ref|NP_000434.1| ATP-binding cassette, subfamily B, m... 737 0.0
gi|22775296|gb|AAN07779.1| multidrug resistance p-glycoprotein [... 737 0.0
gi|45361353|ref|NP_989254.1| hypothetical protein MGC76216 [Xeno... 736 0.0
gi|31442763|gb|AAN07780.2| multidrug resistance p-glycoprotein [... 734 0.0
gi|126930|sp|P23174|MDR3_CRIGR Multidrug resistance protein 3 (P... 733 0.0
gi|46394984|gb|AAS91648.1| multidrug resistance protein; P-glyco... 733 0.0
gi|46394982|gb|AAS91647.1| multidrug resistance protein 1; P-gly... 733 0.0
gi|8926217|gb|AAF81747.1| his-tagged-multidrug resistance glycop... 733 0.0
gi|2353264|gb|AAB69423.1| P-glycoprotein [Homo sapiens] 733 0.0
gi|2149087|gb|AAB58489.1| multidrug resistance protein-1 [Ovis a... 732 0.0
gi|2852441|gb|AAC02113.1| multidrug resistance p-glycoprotein [C... 731 0.0
gi|22759019|gb|AAN05645.1| multidrug resistance p-glycoprotein [... 730 0.0
gi|9961250|ref|NP_061337.1| ATP-binding cassette, subfamily B, m... 730 0.0
gi|6981354|ref|NP_036822.1| ATP-binding cassette, sub-family B (... 729 0.0
gi|48267183|gb|AAQ63650.3| multi-drug resistance P-glycoprotein ... 729 0.0
gi|17569143|ref|NP_509901.1| P-GlycoProtein related (pgp-3) [Cae... 728 0.0
gi|7511698|pir||T31073 multidrug resistance p-glycoprotein - nem... 728 0.0
gi|6679297|ref|NP_032856.1| ATP-binding cassette, sub-family B (... 728 0.0
gi|39594784|emb|CAE70652.1| Hypothetical protein CBG17357 [Caeno... 720 0.0
gi|27656758|gb|AAO20902.1| Mdr2 [Takifugu rubripes] 718 0.0
gi|39595964|emb|CAE67467.1| Hypothetical protein CBG12969 [Caeno... 711 0.0
gi|47225423|emb|CAG11906.1| unnamed protein product [Tetraodon n... 707 0.0
gi|22535563|dbj|BAC10738.1| putative multidrug resistance protei... 706 0.0
gi|283552|pir||S27338 P-glycoprotein C - Caenorhabditis elegans ... 704 0.0
gi|72475|pir||DVMS1A multidrug resistance protein 1a - mouse (fr... 704 0.0
gi|9961252|ref|NP_061338.1| ATP-binding cassette, subfamily B, m... 701 0.0
gi|18496816|gb|AAL74249.1| ABC transporter AbcB2 [Dictyostelium ... 692 0.0
gi|15237456|ref|NP_199466.1| ABC transporter family protein [Ara... 692 0.0
gi|13929072|ref|NP_113948.1| ATP-binding cassette, sub-family B ... 691 0.0
gi|7514034|pir||T42228 P-glycoprotein sister - rat >gnl|BL_ORD_I... 689 0.0
gi|22026798|ref|NP_523740.2| CG8523-PA [Drosophila melanogaster]... 689 0.0
gi|11038656|ref|NP_066302.1| ATP-binding cassette, sub-family B,... 687 0.0
gi|12643301|sp|O95342|AB11_HUMAN Bile salt export pump (ATP-bind... 686 0.0
gi|40644167|emb|CAC86593.1| sister of P-glycoprotein [Platichthy... 686 0.0
gi|4704820|gb|AAD28285.1| bile salt export pump [Homo sapiens] 685 0.0
gi|21536378|ref|NP_003733.2| ATP-binding cassette, sub-family B ... 685 0.0
gi|17567265|ref|NP_510126.1| P-GlycoProtein related (pgp-12) [Ca... 684 0.0
gi|14030565|gb|AAK52958.1| bile salt export pump [Raja erinacea] 684 0.0
gi|18496818|gb|AAL74250.1| ABC transporter AbcB3 [Dictyostelium ... 682 0.0
gi|157873|gb|AAA16186.1| P-glycoprotein/multidrug resistance pro... 680 0.0
gi|1079107|pir||A47377 multidrug resistance protein Mdr50 - frui... 680 0.0
gi|39587992|emb|CAE57223.1| Hypothetical protein CBG00086 [Caeno... 679 0.0
gi|15217785|ref|NP_171753.1| multidrug resistance P-glycoprotein... 679 0.0
gi|31213429|ref|XP_315658.1| ENSANGP00000021663 [Anopheles gambi... 677 0.0
gi|15234322|ref|NP_192091.1| multidrug resistance P-glycoprotein... 676 0.0
gi|25455873|pir||T52319 P-glycoprotein-like protein pgp3 [import... 675 0.0
gi|17567269|ref|NP_510128.1| P-GlycoProtein related (146.8 kD) (... 675 0.0
gi|19032275|dbj|BAB85651.1| multidrug resistance protein 1 homol... 674 0.0
gi|6472653|dbj|BAA87071.1| multi-drug resistance related mRNA [F... 673 0.0
gi|15226477|ref|NP_182223.1| multidrug resistant (MDR) ABC trans... 672 0.0
gi|27368855|emb|CAD59585.1| MDR-like ABC transporter [Oryza sati... 672 0.0
gi|27368859|emb|CAD59587.1| MDR-like ABC transporter [Oryza sati... 672 0.0
gi|34913530|ref|NP_918112.1| putative multidrug resistance prote... 669 0.0
gi|39587990|emb|CAE57221.1| Hypothetical protein CBG00083 [Caeno... 669 0.0
gi|39587988|emb|CAE57219.1| Hypothetical protein CBG00079 [Caeno... 668 0.0
gi|15234323|ref|NP_192092.1| multidrug resistance P-glycoprotein... 667 0.0
gi|4204793|gb|AAD10836.1| P-glycoprotein [Solanum tuberosum] 667 0.0
gi|39587987|emb|CAE57218.1| Hypothetical protein CBG00078 [Caeno... 665 0.0
gi|46390486|dbj|BAD15946.1| putative MDR-like ABC transporter [O... 665 0.0
gi|50750485|ref|XP_422016.1| PREDICTED: similar to liver bile sa... 664 0.0
gi|15217786|ref|NP_171754.1| multidrug resistance P-glycoprotein... 663 0.0
gi|15228695|ref|NP_191774.1| multidrug resistant (MDR) ABC trans... 662 0.0
gi|12585141|sp|Q9N0V3|AB11_RABIT Bile salt export pump (ATP-bind... 662 0.0
gi|25297456|pir||F86155 probable ABC transporter [imported] - Ar... 660 0.0
gi|34911450|ref|NP_917072.1| putative multidrug resistance prote... 660 0.0
gi|25407562|pir||H85202 hypothetical protein AT4g18050 [imported... 659 0.0
gi|22328760|ref|NP_193539.2| ABC transporter family protein [Ara... 657 0.0
gi|15228052|ref|NP_181228.1| multidrug resistance P-glycoprotein... 656 0.0
gi|17567271|ref|NP_510129.1| P-GlycoProtein related (pgp-15) [Ca... 655 0.0
gi|50556486|ref|XP_505651.1| hypothetical protein [Yarrowia lipo... 652 0.0
gi|422285|pir||S30327 multidrug resistance protein 1 - Entamoeba... 652 0.0
gi|22655312|gb|AAM98246.1| putative ABC transporter [Arabidopsis... 651 0.0
gi|393116|gb|AAA93553.1| P-glycoprotein 5 650 0.0
gi|14715462|dbj|BAB62040.1| CjMDR1 [Coptis japonica] 648 0.0
gi|27368865|emb|CAD59590.1| MDR-like ABC transporter [Oryza sati... 648 0.0
gi|27368849|emb|CAD59582.1| MDR-like ABC transporter [Oryza sati... 647 0.0
gi|266518|sp|Q00449|MDR4_DROME Multidrug resistance protein homo... 645 0.0
gi|24653245|ref|NP_523724.2| CG3879-PA [Drosophila melanogaster]... 645 0.0
gi|22331385|ref|NP_683599.1| P-glycoprotein, putative [Arabidops... 643 0.0
gi|15228506|ref|NP_189528.1| multidrug resistance P-glycoprotein... 643 0.0
gi|24324262|gb|AAN28720.2| MDR-like p-glycoprotein [Arabidopsis ... 643 0.0
gi|9294577|dbj|BAB02858.1| multidrug resistance p-glycoprotein; ... 642 0.0
gi|34913544|ref|NP_918119.1| putative multidrug resistance prote... 641 0.0
gi|50543630|ref|XP_499981.1| hypothetical protein [Yarrowia lipo... 641 0.0
gi|422286|pir||S30328 multidrug resistance protein 2 - Entamoeba... 641 0.0
gi|48094917|ref|XP_394305.1| similar to ENSANGP00000021663 [Apis... 640 0.0
gi|50546639|ref|XP_500789.1| hypothetical protein [Yarrowia lipo... 640 0.0
gi|26449438|dbj|BAC41846.1| putative P-glycoprotein [Arabidopsis... 640 0.0
gi|27368847|emb|CAD59581.1| MDR-like ABC transporter [Oryza sati... 638 0.0
gi|15236067|ref|NP_194326.1| multidrug resistance P-glycoprotein... 637 0.0
gi|15229473|ref|NP_189475.1| ABC transporter family protein [Ara... 637 0.0
gi|5733124|gb|AAD49436.1| P-glycoprotein [Onchocerca volvulus] 637 0.0
gi|34894326|ref|NP_908488.1| unnamed protein product [Oryza sati... 637 0.0
gi|15232977|ref|NP_189479.1| P-glycoprotein, putative [Arabidops... 636 e-180
gi|5456701|gb|AAD43626.1| multidrug resistance protein MDR [Emer... 636 e-180
gi|20466380|gb|AAM20507.1| P-glycoprotein-2 [Arabidopsis thaliana] 635 e-180
gi|15232978|ref|NP_189480.1| P-glycoprotein, putative [Arabidops... 635 e-180
gi|49089458|ref|XP_406437.1| hypothetical protein AN2300.2 [Aspe... 635 e-180
gi|15147363|gb|AAG01549.3| multidrug resistance protein MDR [Tri... 635 e-180
gi|46390962|dbj|BAD16475.1| putative multidrug resistance p-glyc... 635 e-180
gi|49080124|ref|XP_403624.1| hypothetical protein UM06009.1 [Ust... 633 e-180
gi|2673951|gb|AAB88657.1| multidrug resistance protein 1 [Asperg... 632 e-179
gi|17567267|ref|NP_510127.1| P-GlycoProtein related (pgp-13) [Ca... 632 e-179
gi|15217776|ref|NP_174115.1| multidrug resistance P-glycoprotein... 631 e-179
gi|15220188|ref|NP_172538.1| P-glycoprotein, putative [Arabidops... 630 e-179
gi|6671365|gb|AAF23176.1| P-glycoprotein [Gossypium hirsutum] 630 e-178
gi|15217809|ref|NP_174122.1| multidrug resistance P-glycoprotein... 628 e-178
gi|21740907|emb|CAD40903.1| OSJNBa0036B21.21 [Oryza sativa (japo... 627 e-178
gi|27368851|emb|CAD59583.1| MDR-like ABC transporter [Oryza sati... 627 e-178
gi|9294571|dbj|BAB02852.1| multidrug resistance p-glycoprotein; ... 626 e-177
gi|13641444|gb|AAK31736.1| p-glycoprotein [Mucor racemosus] 624 e-177
gi|15232975|ref|NP_189477.1| ABC transporter family protein [Ara... 624 e-177
gi|21464386|gb|AAM51996.1| RE14657p [Drosophila melanogaster] 623 e-177
gi|103252|pir||B41249 multidrug resistance protein homolog Mdr65... 623 e-176
gi|17136662|ref|NP_476831.1| CG10181-PA [Drosophila melanogaster... 622 e-176
gi|18033873|gb|AAL57243.1| ATP-binding cassette transporter ABC4... 619 e-175
gi|38049160|gb|AAR10387.1| P-glycoprotein 1 [Sorghum bicolor] 619 e-175
gi|50260330|gb|EAL22989.1| hypothetical protein CNBA7570 [Crypto... 619 e-175
gi|45735908|dbj|BAD12940.1| putative P-glycoprotein 1 [Oryza sat... 617 e-175
gi|4574224|gb|AAD23956.1| multidrug resistance transporter homol... 616 e-174
gi|7442649|pir||T06165 multidrug resistance protein 1 homolog - ... 615 e-174
gi|7442651|pir||T14805 hypothetical protein F15J5.20 - Arabidops... 614 e-174
gi|11346278|pir||T43261 multidrug resistance protein 1 - fungus ... 612 e-173
gi|27368839|emb|CAD59577.1| MDR-like ABC transporter [Oryza sati... 610 e-173
gi|27368861|emb|CAD59588.1| MDR-like ABC transporter [Oryza sati... 610 e-172
gi|19075765|ref|NP_588265.1| leptomycin b resistance protein, ab... 609 e-172
gi|7493911|pir||T30882 multidrug resistance protein 1 - Aspergil... 608 e-172
gi|24659289|ref|NP_648040.1| CG10226-PA [Drosophila melanogaster... 607 e-172
gi|218550|dbj|BAA01537.1| pmd1 protein [Schizosaccharomyces pombe] 607 e-172
gi|34910738|ref|NP_916716.1| putative P-glycoprotein [Oryza sati... 607 e-172
gi|9294508|dbj|BAB02613.1| P-glycoprotein; multi-drug resistance... 607 e-172
gi|27368845|emb|CAD59580.1| MDR-like ABC transporter [Oryza sati... 606 e-171
gi|7494503|pir||T30855 multidrug resistance protein 2 - fluke (S... 594 e-168
gi|33307712|gb|AAQ03033.1| P-glycoprotein [Homo sapiens] 592 e-167
gi|38345252|emb|CAD41096.2| OSJNBb0011N17.13 [Oryza sativa (japo... 588 e-166
gi|38098857|gb|AAR11078.1| ATP binding cassette transporter [Lep... 586 e-165
gi|7494131|pir||T30804 P-glycoprotein 6 - Entamoeba histolytica ... 585 e-165
gi|37806003|dbj|BAC99416.1| putative MDR-like ABC transporter [O... 583 e-165
gi|25297460|pir||B86240 protein F20B24.12 [imported] - Arabidops... 583 e-164
gi|27368867|emb|CAD59591.1| MDR-like ABC transporter [Oryza sati... 579 e-163
gi|46129276|ref|XP_388999.1| hypothetical protein FG08823.1 [Gib... 577 e-163
gi|36413607|ref|NP_848654.2| ATP-binding cassette, sub-family B,... 575 e-162
gi|27368843|emb|CAD59579.1| MDR-like ABC transporter [Oryza sati... 574 e-162
gi|37695542|gb|AAR00316.1| PGP1; ZMPGP1 [Zea mays] 569 e-160
gi|27368841|emb|CAD59578.1| MDR-like ABC transporter [Oryza sati... 564 e-159
gi|27368869|emb|CAD59592.1| MDR-like ABC transporter [Oryza sati... 563 e-158
gi|49089656|ref|XP_406486.1| hypothetical protein AN2349.2 [Aspe... 561 e-158
gi|24960750|gb|AAN65444.1| Hypothetical protein [Oryza sativa (j... 559 e-157
gi|5456699|gb|AAD43625.1| ATP-binding cassette multidrug transpo... 555 e-156
gi|33299999|emb|CAA88940.3| Hypothetical protein DH11.3 [Caenorh... 551 e-155
gi|16304396|gb|AAL15148.1| multidrug resistance transporter-like... 551 e-155
gi|49092568|ref|XP_407745.1| hypothetical protein AN3608.2 [Aspe... 544 e-153
gi|46111809|ref|XP_382962.1| hypothetical protein FG02786.1 [Gib... 543 e-152
gi|17532731|ref|NP_495674.1| P-GlycoProtein related (pgp-11) [Ca... 542 e-152
gi|4587971|gb|AAD25925.1| ABC transporter protein AtrC [Emericel... 540 e-151
gi|46109604|ref|XP_381860.1| hypothetical protein FG01684.1 [Gib... 538 e-151
gi|49081308|ref|XP_404076.1| hypothetical protein UM06461.1 [Ust... 536 e-150
gi|39587763|emb|CAE67781.1| Hypothetical protein CBG13356 [Caeno... 532 e-149
gi|50732439|ref|XP_418636.1| PREDICTED: similar to Multidrug res... 522 e-146
gi|49084736|ref|XP_404541.1| hypothetical protein AN0404.2 [Aspe... 520 e-145
gi|2360941|gb|AAB69130.1| P-glycoprotein 519 e-145
gi|4521245|dbj|BAA76299.1| LAMDR1 [Leishmania mexicana amazonensis] 514 e-144
gi|32418014|ref|XP_329485.1| hypothetical protein [Neurospora cr... 514 e-144
gi|32400322|dbj|BAC78652.1| ABC transporter [Aspergillus oryzae] 511 e-143
gi|49138261|ref|XP_413479.1| hypothetical protein AN9342.2 [Aspe... 509 e-142
gi|49097828|ref|XP_410374.1| hypothetical protein AN6237.2 [Aspe... 508 e-142
gi|46107316|ref|XP_380717.1| hypothetical protein FG00541.1 [Gib... 506 e-141
gi|159363|gb|AAA02977.1| P-glycoprotein 506 e-141
gi|7442650|pir||JG0166 LaMDR1 protein - Leishmania mexicana amaz... 503 e-140
gi|32402932|ref|XP_322079.1| hypothetical protein [Neurospora cr... 502 e-140
gi|38101651|gb|EAA48581.1| hypothetical protein MG00239.4 [Magna... 500 e-139
gi|46125007|ref|XP_387057.1| hypothetical protein FG06881.1 [Gib... 499 e-139
gi|17551158|ref|NP_509205.1| P-GlycoProtein related (pgp-10) [Ca... 499 e-139
gi|13346110|gb|AAK19598.1| putative ABC transporter [Sterkiella ... 498 e-139
gi|39586807|emb|CAE65850.1| Hypothetical protein CBG10984 [Caeno... 496 e-138
gi|7498268|pir||T20386 hypothetical protein DH11.3 - Caenorhabdi... 494 e-138
gi|46114962|ref|XP_383499.1| hypothetical protein FG03323.1 [Gib... 493 e-137
gi|730011|sp|Q06034|MDR1_LEIEN Multidrug resistance protein 1 (P... 489 e-136
gi|7522025|pir||T30191 multidrug resistance protein 1 - Aureobas... 486 e-135
gi|42820674|emb|CAF31987.1| ABC transporter, putative [Aspergill... 484 e-135
gi|20530737|gb|AAM27211.1| multidrug resistance protein 4 [Asper... 484 e-135
gi|18033871|gb|AAL57242.1| ATP-binding cassette transporter ABC3... 481 e-134
gi|46401536|dbj|BAD16632.1| LAMDR2 [Leishmania amazonensis] 457 e-127
gi|38099353|gb|EAA46710.1| hypothetical protein MG09931.4 [Magna... 445 e-123
gi|38108326|gb|EAA54363.1| hypothetical protein MG02348.4 [Magna... 434 e-120
gi|4768949|gb|AAD29692.1| sister of P-glycoprotein [Fundulus het... 427 e-117
gi|25990364|gb|AAN76500.1| P-glycoprotein [Homo sapiens] 417 e-114
gi|18253111|dbj|BAB83959.1| multidrug resistance p-glycoprotein ... 410 e-112
gi|47212418|emb|CAG12367.1| unnamed protein product [Tetraodon n... 409 e-112
gi|34935680|ref|XP_234725.2| similar to P-glycoprotein [Rattus n... 399 e-109
gi|45735907|dbj|BAD12939.1| putative P-glycoprotein 1 [Oryza sat... 398 e-109
gi|47225422|emb|CAG11905.1| unnamed protein product [Tetraodon n... 388 e-106
gi|45775220|gb|AAK83023.2| truncated P-glycoprotein [Rattus norv... 387 e-105
gi|45735909|dbj|BAD12941.1| putative P-glycoprotein 1 [Oryza sat... 385 e-105
gi|72478|pir||DVHY2C multidrug resistance protein 2 - Chinese ha... 382 e-104
gi|191159|gb|AAA37006.1| P-glycoprotein (pgp1) 371 e-101
gi|191153|gb|AAA37003.1| p-glycoprotein 359 2e-97
gi|47218631|emb|CAG04960.1| unnamed protein product [Tetraodon n... 345 4e-93
gi|12230247|sp|P78966|MAM1_SCHPO Mating factor M secretion prote... 341 7e-92
gi|50291615|ref|XP_448240.1| unnamed protein product [Candida gl... 337 1e-90
gi|50425037|ref|XP_461110.1| unnamed protein product [Debaryomyc... 334 1e-89
gi|41052996|dbj|BAD07905.1| putative MDR-like ABC transporter [O... 330 1e-88
gi|47900485|gb|AAT39242.1| putative P-glycoprotein [Oryza sativa... 326 2e-87
gi|19112862|ref|NP_596070.1| abc transporter [Schizosaccharomyce... 322 3e-86
gi|27753995|ref|NP_083296.2| RIKEN cDNA 4833412N02 [Mus musculus... 318 5e-85
gi|26339816|dbj|BAC33571.1| unnamed protein product [Mus musculus] 318 5e-85
gi|26345292|dbj|BAC36297.1| unnamed protein product [Mus musculus] 316 2e-84
gi|12278525|gb|AAG49002.1| putative ABC transporter [Hordeum vul... 313 3e-83
gi|34853987|ref|XP_342615.1| similar to RIKEN cDNA 4833412N02 [R... 311 8e-83
gi|12061244|gb|AAG45492.1| 36I5.4 [Oryza sativa (japonica cultiv... 311 1e-82
gi|18496654|gb|AAL74186.1| putative ABC transporter [Triticum mo... 310 2e-82
gi|20453064|gb|AAM19777.1| At2g39480/F12L6.14 [Arabidopsis thali... 309 4e-82
gi|15225474|ref|NP_181480.1| ABC transporter family protein [Ara... 309 4e-82
gi|10241621|emb|CAC09461.1| putative P-glycoprotein [Oryza sativ... 309 4e-82
gi|10177549|dbj|BAB10828.1| ABC transporter-like protein [Arabid... 308 7e-82
gi|22327455|ref|NP_198720.2| ABC transporter (TAP2) [Arabidopsis... 308 7e-82
gi|19335724|gb|AAL85486.1| transporter associated with antigen p... 307 1e-81
gi|15233244|ref|NP_191092.1| ABC transporter family protein [Ara... 306 3e-81
gi|21326114|gb|AAM47580.1| putative ABC-transporter-like protein... 305 6e-81
gi|18496655|gb|AAL74187.1| putative ABC transporter [Triticum mo... 305 7e-81
gi|6005804|ref|NP_009119.1| ATP-binding cassette, sub-family B, ... 304 1e-80
gi|13123950|sp|Q9NUT2|ABC8_HUMAN ATP-binding cassette, sub-famil... 304 1e-80
gi|1174535|gb|AAA86666.1| ATP-binding cassette protein [Fasciola... 303 2e-80
gi|7023646|dbj|BAA92038.1| unnamed protein product [Homo sapiens] 303 3e-80
gi|12278526|gb|AAG49003.1| putative ABC transporter [Hordeum vul... 303 3e-80
gi|21753735|dbj|BAC04392.1| unnamed protein product [Homo sapiens] 302 5e-80
gi|27368853|emb|CAD59584.1| MDR-like ABC transporter [Oryza sati... 301 1e-79
gi|19698967|gb|AAL91219.1| P-glycoprotein, putative [Arabidopsis... 301 1e-79
gi|18875456|gb|AAL74251.2| ABC transporter AbcB4 [Dictyostelium ... 300 2e-79
gi|18124158|gb|AAL59848.1| ATP-binding cassette protein 3 [Crypt... 299 3e-79
gi|32399046|emb|CAD98286.1| ATP-binding cassette transporter [Cr... 299 3e-79
gi|18496814|gb|AAL74248.1| ABC transporter AbcB1 [Dictyostelium ... 297 2e-78
gi|22974777|ref|ZP_00020923.1| hypothetical protein [Chloroflexu... 295 8e-78
gi|1708329|sp|P53706|HST6_CANAL ATP-dependent permease HST6 (STE... 295 8e-78
gi|46437756|gb|EAK97097.1| hypothetical protein CaO19.7440 [Cand... 295 8e-78
gi|34525|emb|CAA29547.1| P-glycoprotein (431 AA) [Homo sapiens] 294 1e-77
gi|39580953|emb|CAE72923.1| Hypothetical protein CBG20243 [Caeno... 293 2e-77
gi|40787796|gb|AAH64930.1| ATP-binding cassette, sub-family B, m... 293 2e-77
gi|9961244|ref|NP_036221.1| ATP-binding cassette, sub-family B, ... 292 4e-77
gi|12248755|dbj|BAB20265.1| mono ATP-binding cassette protein [H... 289 3e-76
gi|17511077|ref|NP_491754.1| HAlF transporter, PGP related (90.8... 288 5e-76
gi|5733401|gb|AAD49563.1| P-glycoprotein-like protein [Onchocerc... 288 5e-76
gi|7511165|pir||T32865 hypothetical protein ZK484.2 - Caenorhabd... 288 5e-76
gi|17533971|ref|NP_495537.1| HAlF transporter, PGP related (haf-... 288 9e-76
gi|24641565|ref|NP_572810.1| CG1824-PA [Drosophila melanogaster]... 288 9e-76
gi|31216972|ref|XP_316337.1| ENSANGP00000013796 [Anopheles gambi... 287 2e-75
gi|34906082|ref|NP_914388.1| putative P-glycoprotein [Oryza sati... 286 2e-75
gi|34851887|ref|XP_341718.1| similar to ABC transporter [Rattus ... 286 4e-75
gi|17543740|ref|NP_502776.1| HAlF transporter, PGP related (haf-... 286 4e-75
gi|39582351|emb|CAE67600.1| Hypothetical protein CBG13145 [Caeno... 286 4e-75
gi|22971760|ref|ZP_00018688.1| hypothetical protein [Chloroflexu... 285 8e-75
gi|9506367|ref|NP_062425.1| ATP-binding cassette, sub-family B, ... 285 8e-75
gi|17229638|ref|NP_486186.1| ATP-binding protein of ABC transpor... 284 1e-74
gi|1743404|emb|CAB05917.1| transport-associated protein [Salmo s... 283 2e-74
gi|39581765|emb|CAE74138.1| Hypothetical protein CBG21809 [Caeno... 283 3e-74
gi|9992887|gb|AAG11416.1| TagA [Dictyostelium discoideum] 282 4e-74
gi|5823084|gb|AAD53033.1| TAP1 protein [Oncorhynchus mykiss] 282 5e-74
gi|49077780|ref|XP_402711.1| hypothetical protein UM05096.1 [Ust... 280 3e-73
gi|48730042|ref|ZP_00263791.1| COG1132: ABC-type multidrug trans... 278 7e-73
gi|27366635|ref|NP_762162.1| ABC-type multidrug transport system... 278 1e-72
gi|47077792|dbj|BAD18770.1| unnamed protein product [Homo sapiens] 278 1e-72
gi|17565938|ref|NP_506645.1| HAlF transporter, PGP related (haf-... 277 2e-72
gi|7510080|pir||T31617 hypothetical protein Y50E8A.m - Caenorhab... 277 2e-72
gi|22959359|ref|ZP_00007012.1| COG1132: ABC-type multidrug trans... 277 2e-72
gi|39583384|emb|CAE66359.1| Hypothetical protein CBG11616 [Caeno... 277 2e-72
gi|37676347|ref|NP_936743.1| ABC-type multidrug transport system... 277 2e-72
gi|9955966|ref|NP_062571.1| ATP-binding cassette, sub-family B (... 276 4e-72
gi|26006275|dbj|BAC41480.1| mKIAA1520 protein [Mus musculus] 276 4e-72
gi|22095457|sp|Q9JJ59|ABC9_MOUSE ATP-binding cassette, sub-famil... 276 4e-72
gi|27452581|gb|AAN71739.1| ABCB9-like TAP-family protein [Petrom... 275 5e-72
gi|30519701|emb|CAD90041.1| putative ATP-binding cassette transp... 275 6e-72
gi|9845230|ref|NP_063928.1| ATP-binding cassette, sub-family B, ... 275 6e-72
gi|15808008|ref|NP_285672.1| ABC transporter, ATP-binding protei... 275 8e-72
gi|11560034|ref|NP_071574.1| TAP-like ABC transporter [Rattus no... 274 1e-71
gi|23469088|ref|ZP_00124423.1| COG1132: ABC-type multidrug trans... 273 2e-71
gi|28900647|ref|NP_800302.1| putative ATP-binding/permease fusio... 273 2e-71
gi|16330165|ref|NP_440893.1| ABC transporter [Synechocystis sp. ... 273 2e-71
gi|15596310|ref|NP_249804.1| probable ATP-binding/permease fusio... 272 4e-71
gi|32041123|ref|ZP_00138706.1| COG1132: ABC-type multidrug trans... 272 4e-71
gi|48895152|ref|ZP_00328136.1| COG1132: ABC-type multidrug trans... 272 4e-71
gi|15613504|ref|NP_241807.1| ABC transporter (ATP-binding protei... 271 9e-71
gi|39992420|gb|AAH64384.1| ABCB9 protein [Homo sapiens] 270 2e-70
gi|33636348|dbj|BAC81752.1| hydrophobic compound transport facto... 270 2e-70
gi|46916508|emb|CAG23273.1| putative ATP-binding/permease fusion... 270 2e-70
gi|5911322|gb|AAD55751.1| transporter associated with antigen pr... 270 2e-70
gi|49474685|ref|YP_032727.1| ABC transporter, ATP-binding protei... 270 3e-70
gi|2673955|gb|AAB88659.1| multidrug resistance protein 2 [Asperg... 269 3e-70
gi|32966961|gb|AAP92331.1| multixenobiotic resistance protein [C... 269 4e-70
gi|425474|gb|AAA66476.1| SMDR1 269 4e-70
gi|45506572|ref|ZP_00158925.1| COG1132: ABC-type multidrug trans... 269 4e-70
gi|23502573|ref|NP_698700.1| ABC transporter, ATP binding/permea... 268 6e-70
gi|5911326|gb|AAD55753.1| transporter associated with antigen pr... 268 8e-70
gi|28869225|ref|NP_791844.1| ABC transporter, ATP-binding/permea... 267 1e-69
gi|21622336|emb|CAD36977.1| probable multidrug resistance protei... 267 1e-69
gi|49077826|ref|XP_402729.1| hypothetical protein UM05114.1 [Ust... 267 1e-69
gi|22760375|dbj|BAC11171.1| unnamed protein product [Homo sapiens] 267 2e-69
gi|21673056|ref|NP_661121.1| ABC transporter, ATP-binding protei... 266 2e-69
gi|26988843|ref|NP_744268.1| ABC efflux transporter, permease/AT... 266 2e-69
gi|17986606|ref|NP_539240.1| PROBABLE TRANSPORT ATP-BINDING PROT... 266 3e-69
gi|27376619|ref|NP_768148.1| HlyB/MsbA family ABC transporter [B... 266 4e-69
gi|18124194|gb|AAL59859.1| transporter associated with antigen p... 265 6e-69
gi|23098860|ref|NP_692326.1| ABC transporter ATP-binding protein... 265 6e-69
gi|22995060|ref|ZP_00039543.1| COG1132: ABC-type multidrug trans... 264 1e-68
gi|50551833|ref|XP_503391.1| hypothetical protein [Yarrowia lipo... 264 1e-68
gi|5823088|gb|AAD53035.1| TAP2B protein [Oncorhynchus mykiss] 264 1e-68
gi|21242281|ref|NP_641863.1| ABC transporter ATP-binding protein... 264 1e-68
gi|48864170|ref|ZP_00318063.1| COG1132: ABC-type multidrug trans... 264 1e-68
gi|49476161|ref|YP_034202.1| ABC transporter, ATP-binding protei... 264 1e-68
gi|15924856|ref|NP_372390.1| ABC transporter homolog [Staphyloco... 263 2e-68
gi|46119497|ref|ZP_00176704.2| COG1132: ABC-type multidrug trans... 263 2e-68
gi|1743406|emb|CAB05918.1| transport-associated protein [Salmo s... 263 2e-68
gi|23127335|ref|ZP_00109208.1| COG1132: ABC-type multidrug trans... 262 4e-68
gi|30248729|ref|NP_840799.1| ABC transporter, fused permease and... 262 4e-68
gi|15923633|ref|NP_371167.1| ATP-binding cassette transporter A ... 262 5e-68
gi|21230937|ref|NP_636854.1| ABC transporter ATP-binding protein... 261 7e-68
gi|22997178|ref|ZP_00041414.1| COG1132: ABC-type multidrug trans... 261 7e-68
gi|23125993|ref|ZP_00107905.1| COG2274: ABC-type bacteriocin/lan... 261 9e-68
gi|15839171|ref|NP_299859.1| ABC transporter ATP-binding protein... 261 9e-68
gi|23016084|ref|ZP_00055844.1| COG1132: ABC-type multidrug trans... 261 9e-68
gi|46130296|ref|ZP_00165119.2| COG1132: ABC-type multidrug trans... 261 1e-67
gi|7445809|pir||S72637 hypothetical ABC exporter component A - T... 261 1e-67
gi|48892154|ref|ZP_00325566.1| COG1132: ABC-type multidrug trans... 260 2e-67
gi|28211454|ref|NP_782398.1| multidrug resistance ABC transporte... 260 2e-67
gi|21282334|ref|NP_645422.1| ATP-binding cassette transporter A ... 260 2e-67
gi|13473363|ref|NP_104930.1| ABC transporter, ATP-binding protei... 260 2e-67
gi|48771097|ref|ZP_00275440.1| COG1132: ABC-type multidrug trans... 259 3e-67
gi|28199828|ref|NP_780142.1| ABC transporter ATP-binding protein... 259 3e-67
gi|48855938|ref|ZP_00310096.1| COG1132: ABC-type multidrug trans... 259 4e-67
gi|1262136|emb|CAA62898.1| ATP-binding cassette transporter A [S... 259 4e-67
gi|24216393|ref|NP_713874.1| Probable transport ATP-binding prot... 259 4e-67
gi|15966528|ref|NP_386881.1| PROBABLE ABC TRANSPORTER ATP-BINDIN... 258 6e-67
gi|525293|emb|CAA53758.1| PGP1 [Trichomonas vaginalis] 258 6e-67
gi|23397593|ref|NP_569844.2| CG3156-PA [Drosophila melanogaster]... 258 8e-67
gi|19703933|ref|NP_603495.1| Phospholipid-lipopolysaccharide ABC... 258 8e-67
gi|22298505|ref|NP_681752.1| ABC transporter ATP-binding protein... 258 1e-66
gi|45656430|ref|YP_000516.1| ABC transporter, ATP-binding protei... 258 1e-66
gi|20808867|ref|NP_624038.1| ABC-type multidrug/protein/lipid tr... 258 1e-66
gi|33240546|ref|NP_875488.1| ABC-type multidrug transport system... 257 1e-66
gi|15891205|ref|NP_356877.1| AGR_L_2179p [Agrobacterium tumefaci... 257 1e-66
gi|15963913|ref|NP_384266.1| PUTATIVE ATP-BINDING ABC TRANSPORTE... 257 2e-66
gi|46913988|emb|CAG20770.1| putative transport ATP-binding prote... 257 2e-66
gi|27365418|ref|NP_760946.1| Transport ATP-binding protein MsbA ... 257 2e-66
gi|1016270|gb|AAA79094.1| p-glycoprotein 257 2e-66
gi|37694082|gb|AAO72317.1| multidrug resistance associated prote... 257 2e-66
gi|15894891|ref|NP_348240.1| ABC-type multidrug/protein/lipid tr... 256 2e-66
gi|39933996|ref|NP_946272.1| ABC transporter, ATP-binding protei... 256 2e-66
gi|27381404|ref|NP_772933.1| HlyB/MsbA family ABC transporter [B... 256 2e-66
gi|6323217|ref|NP_013289.1| ATP-binding cassette (ABC) transport... 256 3e-66
gi|37680540|ref|NP_935149.1| transport ATP-binding protein MsbA ... 256 3e-66
gi|49477449|ref|YP_036121.1| multidrug resistance ABC transporte... 256 4e-66
gi|39582604|emb|CAE63923.1| Hypothetical protein CBG08495 [Caeno... 255 5e-66
gi|23098355|ref|NP_691821.1| ABC transporter ATP-binding protein... 255 5e-66
gi|25143468|ref|NP_490828.2| HAlF transporter, PGP related (62.5... 255 5e-66
gi|22298120|ref|NP_681367.1| ABC transporter ATP-binding protein... 255 7e-66
gi|34541348|ref|NP_905827.1| ABC transporter, ATP-binding protei... 255 7e-66
gi|47575345|ref|ZP_00245380.1| COG1132: ABC-type multidrug trans... 255 7e-66
gi|45916934|ref|ZP_00195995.2| COG1132: ABC-type multidrug trans... 254 9e-66
gi|2147880|pir||I48120 P-glycoprotein - Chinese hamster (fragmen... 254 9e-66
gi|25150042|ref|NP_741273.1| heavy Metal Tolerance protein HMT-1... 254 9e-66
gi|33321257|gb|AAQ06435.1| ABC6 protein [Caenorhabditis elegans] 254 9e-66
gi|28210179|ref|NP_781123.1| multidrug resistance ABC transporte... 254 9e-66
gi|30249744|ref|NP_841814.1| ABC transporter, fused permease and... 254 9e-66
gi|30698733|ref|NP_177218.3| ABC transporter (TAP1) [Arabidopsis... 254 1e-65
gi|20807317|ref|NP_622488.1| ABC-type multidrug/protein/lipid tr... 254 1e-65
gi|50085455|ref|YP_046965.1| lipid transport protein, flippase (... 254 1e-65
gi|17509565|ref|NP_490739.1| HAlF transporter, PGP related (haf-... 254 1e-65
gi|2119779|pir||S50217 multidrug resistance protein 3 - rat (fra... 254 1e-65
gi|37525574|ref|NP_928918.1| Probable transport ATP-binding prot... 254 1e-65
gi|27467336|ref|NP_763973.1| ATP-binding cassette transporter A ... 254 1e-65
gi|45521342|ref|ZP_00172862.1| COG1132: ABC-type multidrug trans... 254 1e-65
gi|23100898|ref|NP_694365.1| ABC transporter ATP-binding protein... 254 1e-65
gi|27468468|ref|NP_765105.1| ABC transporter (ATP-binding protei... 253 2e-65
gi|7445902|pir||T13416 hypothetical protein 171D11.2 - fruit fly... 253 2e-65
gi|18310508|ref|NP_562442.1| probable ABC transporter [Clostridi... 253 3e-65
gi|159372|gb|AAA02976.1| multi drug resistance P-glycoprotein 253 3e-65
gi|45506769|ref|ZP_00159120.1| COG1132: ABC-type multidrug trans... 253 3e-65
gi|2126572|pir||JC4554 ABC-type transporter homolog - Staphyloco... 253 3e-65
gi|295584|gb|AAA20681.1| Mdl1p 253 3e-65
gi|15643057|ref|NP_228100.1| ABC transporter, ATP-binding protei... 253 3e-65
gi|33863351|ref|NP_894911.1| ABC transporter, multidrug efflux f... 253 3e-65
gi|19112543|ref|NP_595751.1| putative permease [Schizosaccharomy... 252 4e-65
gi|48858770|ref|ZP_00312716.1| COG1132: ABC-type multidrug trans... 252 4e-65
gi|2492605|sp|P97998|MDL1_CANAL ATP-dependent permease MDL1 >gnl... 252 4e-65
gi|46440040|gb|EAK99351.1| hypothetical protein CaO19.2615 [Cand... 252 4e-65
gi|15235382|ref|NP_194591.1| ABC transporter family protein [Ara... 252 4e-65
gi|28897756|ref|NP_797361.1| transport ATP-binding protein MsbA ... 252 6e-65
gi|23129118|ref|ZP_00110951.1| COG1132: ABC-type multidrug trans... 252 6e-65
gi|15613688|ref|NP_241991.1| ABC transporter (ATP-binding protei... 252 6e-65
gi|29654183|ref|NP_819875.1| ABC transporter, ATP-binding/permea... 252 6e-65
gi|16077935|ref|NP_388749.1| ygaD [Bacillus subtilis subsp. subt... 252 6e-65
gi|31194451|ref|XP_306173.1| ENSANGP00000015516 [Anopheles gambi... 252 6e-65
gi|39579434|emb|CAE74830.1| Hypothetical protein CBG22668 [Caeno... 251 7e-65
gi|17228136|ref|NP_484684.1| ATP-binding protein of ABC transpor... 251 7e-65
gi|23127765|ref|ZP_00109628.1| COG1132: ABC-type multidrug trans... 251 7e-65
gi|31206493|ref|XP_312209.1| ENSANGP00000002692 [Anopheles gambi... 251 7e-65
gi|18309509|ref|NP_561443.1| probable ABC transporter [Clostridi... 251 7e-65
gi|16127504|ref|NP_422068.1| ABC transporter, HlyB/MsbA family [... 251 1e-64
gi|17228079|ref|NP_484627.1| ATP-binding protein of ABC transpor... 251 1e-64
gi|16329858|ref|NP_440586.1| ABC transporter [Synechocystis sp. ... 251 1e-64
gi|23124320|ref|ZP_00106317.1| COG2274: ABC-type bacteriocin/lan... 251 1e-64
gi|50304659|ref|XP_452285.1| unnamed protein product [Kluyveromy... 251 1e-64
gi|34497639|ref|NP_901854.1| probable ABC transport protein, msb... 251 1e-64
gi|42527766|ref|NP_972864.1| ABC transporter, ATP-binding/permea... 251 1e-64
gi|31217619|ref|XP_316463.1| ENSANGP00000004277 [Anopheles gambi... 251 1e-64
gi|34496280|ref|NP_900495.1| transport ATP-binding protein msbA ... 250 2e-64
gi|46308813|ref|ZP_00211005.1| COG1132: ABC-type multidrug trans... 250 2e-64
gi|17229419|ref|NP_485967.1| ABC transporter ATP-binding protein... 250 2e-64
gi|17232691|ref|NP_489239.1| ATP-binding protein of ABC transpor... 250 2e-64
gi|15616453|ref|NP_244759.1| ABC transporter (ATP-binding protei... 250 2e-64
gi|50255008|gb|EAL17748.1| hypothetical protein CNBL2610 [Crypto... 250 2e-64
gi|45656478|ref|YP_000564.1| ABC transporter, atp-binding protei... 250 2e-64
gi|48871179|ref|ZP_00323895.1| COG1132: ABC-type multidrug trans... 250 2e-64
gi|23098861|ref|NP_692327.1| ABC transporter ATP-binding protein... 249 3e-64
gi|15237155|ref|NP_200635.1| mitochondrial half-ABC transporter ... 249 3e-64
gi|8176565|dbj|BAA96370.1| ABC protein [Physarum polycephalum] 249 3e-64
gi|33861655|ref|NP_893216.1| ABC transporter, multidrug efflux f... 249 4e-64
gi|17230168|ref|NP_486716.1| toxin secretion ABC transporter ATP... 249 4e-64
gi|23482132|gb|EAA18202.1| transport protein [Plasmodium yoelii ... 249 4e-64
gi|50841666|ref|YP_054893.1| putative ABC transporter [Propionib... 249 4e-64
gi|33602079|ref|NP_889639.1| ABC transporter, ATP-binding protei... 249 4e-64
gi|37522437|ref|NP_925814.1| HlyB/MsbA family ABC transporter [G... 249 4e-64
gi|46119089|ref|ZP_00176074.2| COG1132: ABC-type multidrug trans... 249 5e-64
gi|37781028|gb|AAP36720.1| transporter associated with antigen p... 248 6e-64
gi|27452473|gb|AAN71740.1| ABCB9-like TAP-family protein [Petrom... 248 6e-64
gi|37781024|gb|AAP36718.1| transporter associated with antigen p... 248 6e-64
gi|42781108|ref|NP_978355.1| ABC transporter, ATP-binding/permea... 248 6e-64
gi|37781022|gb|AAP36717.1| transporter associated with antigen p... 248 8e-64
gi|30020094|ref|NP_831725.1| Multidrug resistance ABC transporte... 248 8e-64
gi|47217174|emb|CAG11010.1| unnamed protein product [Tetraodon n... 248 8e-64
gi|48824040|ref|ZP_00285472.1| COG1132: ABC-type multidrug trans... 248 8e-64
gi|29377079|ref|NP_816233.1| ABC transporter, ATP-binding/permea... 248 8e-64
gi|33596261|ref|NP_883904.1| ABC transporter, ATP-binding protei... 248 8e-64
gi|50877523|emb|CAG37363.1| related to ABC-transporter, ATP-bind... 248 8e-64
gi|45916645|ref|ZP_00197576.1| COG1132: ABC-type multidrug trans... 248 1e-63
gi|29377383|ref|NP_816537.1| ABC transporter, ATP-binding/permea... 248 1e-63
gi|23111882|ref|ZP_00097447.1| COG1132: ABC-type multidrug trans... 248 1e-63
gi|2147879|pir||I48119 P-glycoprotein - Chinese hamster (fragmen... 248 1e-63
gi|9187883|emb|CAB97048.1| mitochondrial half-ABC transporter [A... 248 1e-63
gi|33592061|ref|NP_879705.1| ABC transporter, ATP-binding protei... 248 1e-63
gi|50510160|dbj|BAD31127.1| putative ATP-binding cassette, sub-f... 247 1e-63
gi|15987936|gb|AAL12800.1| LktB [Mannheimia glucosida] 247 1e-63
gi|15987916|gb|AAL12785.1| LktB [Mannheimia haemolytica] 247 1e-63
gi|1708223|sp|P55122|HLYB_PASSP Leukotoxin secretion/processing ... 247 1e-63
gi|46113651|ref|ZP_00183228.2| COG1132: ABC-type multidrug trans... 247 1e-63
gi|17561534|ref|NP_506927.1| HAlF transporter, PGP related (haf-... 247 1e-63
gi|25384933|pir||AC2517 hypothetical protein hlyB [imported] - N... 247 2e-63
gi|49094386|ref|XP_408654.1| hypothetical protein AN4517.2 [Aspe... 247 2e-63
gi|30023215|ref|NP_834846.1| Multidrug resistance ABC transporte... 247 2e-63
gi|48850584|ref|ZP_00304826.1| COG1132: ABC-type multidrug trans... 247 2e-63
gi|32475881|ref|NP_868875.1| ABC transporter (ATP-binding protei... 246 2e-63
gi|29348795|ref|NP_812298.1| ABC transporter, ATP-binding protei... 246 2e-63
gi|49478904|ref|YP_039169.1| multidrug resistance ABC transporte... 246 2e-63
gi|15896526|ref|NP_349875.1| ABC-type multidrug/protein/lipid tr... 246 2e-63
gi|50121342|ref|YP_050509.1| putative ABC transporter ATP-bindin... 246 2e-63
gi|17229106|ref|NP_485654.1| toxin secretion ABC transporter ATP... 246 2e-63
gi|49474077|ref|YP_032119.1| ABC transporter, ATP-binding protei... 246 2e-63
gi|46135109|ref|ZP_00162400.2| COG2274: ABC-type bacteriocin/lan... 246 2e-63
gi|23467052|ref|ZP_00122637.1| COG1132: ABC-type multidrug trans... 246 3e-63
>gi|17550138|ref|NP_509810.1| P-GlycoProtein related (pgp-5)
[Caenorhabditis elegans]
gi|7495402|pir||T18939 hypothetical protein C05A9.1 - Caenorhabditis
elegans
gi|3874030|emb|CAA94202.1| Hypothetical protein C05A9.1
[Caenorhabditis elegans]
Length = 1283
Score = 2466 bits (6390), Expect = 0.0
Identities = 1265/1283 (98%), Positives = 1265/1283 (98%)
Frame = -1
Query: 3852 MHLHSLRLXXXXXXXXXXXXXXXXXXSNTNWSNVCKFIKVIVGSTNNFLKKTFGFQIKCT 3673
MHLHSLRL SNTNWSNVCKFIKVIVGSTNNFLKKTFGFQIKCT
Sbjct: 1 MHLHSLRLFCFSYVFFFCSFPLLPFSSNTNWSNVCKFIKVIVGSTNNFLKKTFGFQIKCT 60
Query: 3672 TRYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLF 3493
TRYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLF
Sbjct: 61 TRYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLF 120
Query: 3492 ESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMS 3313
ESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMS
Sbjct: 121 ESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMS 180
Query: 3312 TGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVL 3133
TGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVL
Sbjct: 181 TGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVL 240
Query: 3132 SGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKY 2953
SGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKY
Sbjct: 241 SGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKY 300
Query: 2952 ALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGE 2773
ALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGE
Sbjct: 301 ALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGE 360
Query: 2772 AILHISRLASAIPLTVPIADILLDSDATADEFFSEEIKDTFQGIISFKNVLFSYPTRPDV 2593
AILHISRLASAIPLTVPIADILLDSDATADEFFSEEIKDTFQGIISFKNVLFSYPTRPDV
Sbjct: 361 AILHISRLASAIPLTVPIADILLDSDATADEFFSEEIKDTFQGIISFKNVLFSYPTRPDV 420
Query: 2592 PVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLR 2413
PVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLR
Sbjct: 421 PVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLR 480
Query: 2412 QAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGER 2233
QAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGER
Sbjct: 481 QAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGER 540
Query: 2232 GAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAH 2053
GAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAH
Sbjct: 541 GAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAH 600
Query: 2052 RLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNENEERVTR 1873
RLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNENEERVTR
Sbjct: 601 RLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNENEERVTR 660
Query: 1872 QSSHSDFPSNEISHQKIDQEDDYVKKLIAEIKEEGAKKSNICEIIKYCRSEYCILFIAVL 1693
QSSHSDFPSNEISHQKIDQEDDYVKKLIAEIKEEGAKKSNICEIIKYCRSEYCILFIAVL
Sbjct: 661 QSSHSDFPSNEISHQKIDQEDDYVKKLIAEIKEEGAKKSNICEIIKYCRSEYCILFIAVL 720
Query: 1692 GSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWALSILFLAFTRPIFIFFQYYFFG 1513
GSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWALSILFLAFTRPIFIFFQYYFFG
Sbjct: 721 GSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWALSILFLAFTRPIFIFFQYYFFG 780
Query: 1512 KTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIM 1333
KTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIM
Sbjct: 781 KTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIM 840
Query: 1332 TLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAI 1153
TLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAI
Sbjct: 841 TLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAI 900
Query: 1152 EALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFK 973
EALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFK
Sbjct: 901 EALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFK 960
Query: 972 FGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFHLFTYPAIM 793
FGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFHLFTYPAIM
Sbjct: 961 FGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFHLFTYPAIM 1020
Query: 792 PYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTI 613
PYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTI
Sbjct: 1021 PYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTI 1080
Query: 612 ISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNA 433
ISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNA
Sbjct: 1081 ISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNA 1140
Query: 432 SQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLD 253
SQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLD
Sbjct: 1141 SQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLD 1200
Query: 252 EATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEEL 73
EATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEEL
Sbjct: 1201 EATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEEL 1260
Query: 72 LRKRSIYWRLVQKQGIQVETLIE 4
LRKRSIYWRLVQKQGIQVETLIE
Sbjct: 1261 LRKRSIYWRLVQKQGIQVETLIE 1283
>gi|50507726|emb|CAA94219.3| Hypothetical protein T21E8.2
[Caenorhabditis elegans]
Length = 1263
Score = 1682 bits (4357), Expect = 0.0
Identities = 854/1253 (68%), Positives = 1020/1253 (81%), Gaps = 6/1253 (0%)
Frame = -1
Query: 3753 VCKFIKVIVGSTNNFLKKTFGFQIKCTTRYEKLLFFLGVVFSILTGMCQPFESYTLGETS 3574
+C FI+VI KCT+ +EK LF +GV FS++TG+CQPF SYTLGET+
Sbjct: 24 LCSFIRVI---------------FKCTSCFEKFLFLIGVFFSLVTGLCQPFVSYTLGETA 68
Query: 3573 QVLVKVTNAINNKTIDPVDLAHAYKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVG 3394
QVLV +TNAINNKTIDP DL AY+ +E M +VVL FFL G AYFTF +Q +IMK+VG
Sbjct: 69 QVLVTITNAINNKTIDPADLKKAYEQYERGMYQVVLYFFLCGCAYFTFASIQHAIMKYVG 128
Query: 3393 DNTAYNVRRQYISRLLRKDISYFDGMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDF 3214
DNT Y VR+QYISRLLRKD YFD +STGHLS VLNDN+ERFREVFNEKIALI ALLTDF
Sbjct: 129 DNTTYRVRKQYISRLLRKDAEYFDNVSTGHLSTVLNDNLERFREVFNEKIALIFALLTDF 188
Query: 3213 VIGTILAFYTDWRLACYGTVFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGC 3034
V+GT LAFYTDWRLA YG FS GI SG ++S G MK KQN H +NAGSIAFQ LG
Sbjct: 189 VVGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGA 248
Query: 3033 YKTVSSLNGQQQEVERYTEELKNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANM 2854
YKTV SLNGQ E+ERYTEELK GEKY ++RA ++S+SR YFF N+LN VILY GANM
Sbjct: 249 YKTVCSLNGQNTEIERYTEELKAGEKYGIHRALMYSISRGFTYFFCNSLNTVILYVGANM 308
Query: 2853 IYEGTIEPGVVVRILYYILFGSYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFF 2674
IY G++EP VVVRI +Y++FG++CL EA+ HISRLA AI T PIA++L+ D ++
Sbjct: 309 IYSGSLEPAVVVRIFHYMMFGAFCLSEALPHISRLAGAISSTAPIAEMLIKEDNVIEKDE 368
Query: 2673 SE-EIKDTFQGIISFKNVLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQL 2497
++ +++ G ISFKNV FSYPTRPD VLK ISF+VQ GECIALVGASGSGKSTV+QL
Sbjct: 369 TDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQL 428
Query: 2496 LLHYYNIDSGRISIDGNDIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQE 2317
LLHYYNIDSG I IDG D+ ++NIK+LR+ +GVV QEPVLFNT+IEENIRFG P+ + E
Sbjct: 429 LLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPE 488
Query: 2316 IIDALKNANAFDFVCNFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATS 2137
I AL+ ANA+DFVC+FP GIKTIVGERG QLSGGQKQRIAIARTLVRNP+ILLLDEATS
Sbjct: 489 IYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATS 548
Query: 2136 ALDNESEFIVQEALQKASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMN 1957
ALDNESE +VQ+AL+ AS GRTTIVVAHRLSTIRNA+KIIVM+KGEIVEVG+H +LIA
Sbjct: 549 ALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKR 608
Query: 1956 GVYNNLVQTQLMSTNYEKMNENEERVTRQSSHSDFPSNEISHQKIDQED-----DYVKKL 1792
GVYN+LVQ QL+ + ++ E RQ S P + + Q+ D D ++++
Sbjct: 609 GVYNDLVQAQLLES-HDDHEELPPLAARQLSQELSPLHSYAIQRSTSNDAGVHDDDMERI 667
Query: 1791 IAEIKEEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDK 1612
+ E+ +EGAKKSN+ EI+K CR +YC LFIAV GSAIQG+ YP+ +QL++++YE +A
Sbjct: 668 LDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIG 727
Query: 1611 DEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYD 1432
++ML SH WALS +FLA RP+ ++ QYY+FGK +E+LS +LR SF H++SLPCAFYD
Sbjct: 728 EDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYD 787
Query: 1431 DPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFC 1252
DP H+ATRLSNRLN DSSNV AAVDDRLG VIMT+VAI +A+ + Y WKM+L+VL+F
Sbjct: 788 DPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLIFF 847
Query: 1251 PLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQ 1072
PLLYLA YC D + +++ED+IAFE SNR AIEALEN+RTVRALN+E++++ L++ HLQ
Sbjct: 848 PLLYLAEYCYDAATETSIQEDTIAFENSNRTAIEALENMRTVRALNLEDKIMSLISEHLQ 907
Query: 1071 KIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTA 892
KI SYFKRA+IQG ANG + SCY F+Y+VSFKFGT+L LR+E+ PMDTYL+L TLSMTA
Sbjct: 908 KIHKSYFKRAIIQGAANGLSLSCYLFVYSVSFKFGTYLALRKEVAPMDTYLILETLSMTA 967
Query: 891 SYAGSAVAYLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQ 712
+ AGSA AYLPD++KA+HAAGLIFHLFTYPA MP+ SS GK+NI+ GEI +NV F Y Q
Sbjct: 968 NMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQ 1027
Query: 711 RSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNL 532
R D+MIL+GV+LK+ G+TLALVGPSG GKSTIISLLERFYHAVDGEVKID ENV D+NL
Sbjct: 1028 RPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINL 1087
Query: 531 HHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDT 352
+HLR +++LVSQEP LFNCSI+EN L+G++ + QLE+++AL+ ANAF+FV QFPQGLDT
Sbjct: 1088 NHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDT 1147
Query: 351 LVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLST 172
+VGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLST
Sbjct: 1148 IVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLST 1207
Query: 171 VVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQVET 13
VVVAHRL TVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQVET
Sbjct: 1208 VVVAHRLLTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQVET 1260
>gi|17569909|ref|NP_509812.1| P-GlycoProtein related (pgp-7)
[Caenorhabditis elegans]
Length = 1269
Score = 1676 bits (4340), Expect = 0.0
Identities = 854/1259 (67%), Positives = 1020/1259 (80%), Gaps = 12/1259 (0%)
Frame = -1
Query: 3753 VCKFIKVIVGSTNNFLKKTFGFQIKCTTRYEKLLFFLGVVFSILTGMCQPFESYTLGETS 3574
+C FI+VI KCT+ +EK LF +GV FS++TG+CQPF SYTLGET+
Sbjct: 24 LCSFIRVI---------------FKCTSCFEKFLFLIGVFFSLVTGLCQPFVSYTLGETA 68
Query: 3573 QVLVKVTNAINNKTIDPVDLAHAYKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVG 3394
QVLV +TNAINNKTIDP DL AY+ +E M +VVL FFL G AYFTF +Q +IMK+VG
Sbjct: 69 QVLVTITNAINNKTIDPADLKKAYEQYERGMYQVVLYFFLCGCAYFTFASIQHAIMKYVG 128
Query: 3393 DNTAYNVRRQYISRLLRKDISYFDGMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDF 3214
DNT Y VR+QYISRLLRKD YFD +STGHLS VLNDN+ERFREVFNEKIALI ALLTDF
Sbjct: 129 DNTTYRVRKQYISRLLRKDAEYFDNVSTGHLSTVLNDNLERFREVFNEKIALIFALLTDF 188
Query: 3213 VIGTILAFYTDWRLACYGTVFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGC 3034
V+GT LAFYTDWRLA YG FS GI SG ++S G MK KQN H +NAGSIAFQ LG
Sbjct: 189 VVGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGA 248
Query: 3033 YKTVSSLNGQQQEVERYTEELKNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANM 2854
YKTV SLNGQ E+ERYTEELK GEKY ++RA ++S+SR YFF N+LN VILY GANM
Sbjct: 249 YKTVCSLNGQNTEIERYTEELKAGEKYGIHRALMYSISRGFTYFFCNSLNTVILYVGANM 308
Query: 2853 IYEGTIEPGVVVRILYYILFGSYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFF 2674
IY G++EP VVVRI +Y++FG++CL EA+ HISRLA AI T PIA++L+ D ++
Sbjct: 309 IYSGSLEPAVVVRIFHYMMFGAFCLSEALPHISRLAGAISSTAPIAEMLIKEDNVIEKDE 368
Query: 2673 SE-EIKDTFQGIISFKNVLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQL 2497
++ +++ G ISFKNV FSYPTRPD VLK ISF+VQ GECIALVGASGSGKSTV+QL
Sbjct: 369 TDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQL 428
Query: 2496 LLHYYNIDSGRISIDGNDIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQE 2317
LLHYYNIDSG I IDG D+ ++NIK+LR+ +GVV QEPVLFNT+IEENIRFG P+ + E
Sbjct: 429 LLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPE 488
Query: 2316 IIDALKNANAFDFVCNFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATS 2137
I AL+ ANA+DFVC+FP GIKTIVGERG QLSGGQKQRIAIARTLVRNP+ILLLDEATS
Sbjct: 489 IYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATS 548
Query: 2136 ALDNESEFIVQEALQKASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMN 1957
ALDNESE +VQ+AL+ AS GRTTIVVAHRLSTIRNA+KIIVM+KGEIVEVG+H +LIA
Sbjct: 549 ALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKR 608
Query: 1956 GVYNNLVQTQLMSTNYEKMNENEERVTRQSSHSDFPSNEISHQKIDQED-----DYVKKL 1792
GVYN+LVQ QL+ + ++ E RQ S P + + Q+ D D ++++
Sbjct: 609 GVYNDLVQAQLLES-HDDHEELPPLAARQLSQELSPLHSYAIQRSTSNDAGVHDDDMERI 667
Query: 1791 IAEIKEEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDK 1612
+ E+ +EGAKKSN+ EI+K CR +YC LFIAV GSAIQG+ YP+ +QL++++YE +A
Sbjct: 668 LDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIG 727
Query: 1611 DEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYD 1432
++ML SH WALS +FLA RP+ ++ QYY+FGK +E+LS +LR SF H++SLPCAFYD
Sbjct: 728 EDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYD 787
Query: 1431 DPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFC 1252
DP H+ATRLSNRLN DSSNV AAVDDRLG VIMT+VAI +A+ + Y WKM+L+VL+F
Sbjct: 788 DPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLIFF 847
Query: 1251 PLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQ 1072
PLLYLA YC D + +++ED+IAFE SNR AIEALEN+RTVRALN+E++++ L++ HLQ
Sbjct: 848 PLLYLAEYCYDAATETSIQEDTIAFENSNRTAIEALENMRTVRALNLEDKIMSLISEHLQ 907
Query: 1071 KIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTA 892
KI SYFKRA+IQG ANG + SCY F+Y+VSFKFGT+L LR+E+ PMDTYL+L TLSMTA
Sbjct: 908 KIHKSYFKRAIIQGAANGLSLSCYLFVYSVSFKFGTYLALRKEVAPMDTYLILETLSMTA 967
Query: 891 SYAGSAVAYLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQ 712
+ AGSA AYLPD++KA+HAAGLIFHLFTYPA MP+ SS GK+NI+ GEI +NV F Y Q
Sbjct: 968 NMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQ 1027
Query: 711 RSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEV------KIDEEN 550
R D+MIL+GV+LK+ G+TLALVGPSG GKSTIISLLERFYHAVDGEV KID EN
Sbjct: 1028 RPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVVSIDAHKIDSEN 1087
Query: 549 VVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQF 370
V D+NL+HLR +++LVSQEP LFNCSI+EN L+G++ + QLE+++AL+ ANAF+FV QF
Sbjct: 1088 VEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQF 1147
Query: 369 PQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTA 190
PQGLDT+VGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTA
Sbjct: 1148 PQGLDTIVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTA 1207
Query: 189 SERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQVET 13
SERLSTVVVAHRL TVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQVET
Sbjct: 1208 SERLSTVVVAHRLLTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQVET 1266
>gi|39594939|emb|CAE70807.1| Hypothetical protein CBG17569
[Caenorhabditis briggsae]
Length = 1224
Score = 1632 bits (4227), Expect = 0.0
Identities = 837/1227 (68%), Positives = 985/1227 (80%), Gaps = 5/1227 (0%)
Frame = -1
Query: 3681 KCTTRYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAY 3502
KCT+ +EKLLF LG+ FS+LTG+CQPF SYT GE SQVLV +TNAINNKTIDP DL AY
Sbjct: 33 KCTSCFEKLLFMLGIFFSLLTGLCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEKAY 92
Query: 3501 KLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFD 3322
++FE DMN V+L FF G AYFTFG LQFSIMKFVGDNT Y VR+QYISRLLRKD YFD
Sbjct: 93 EVFERDMNSVILHFFFCGCAYFTFGSLQFSIMKFVGDNTTYRVRKQYISRLLRKDARYFD 152
Query: 3321 GMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFG 3142
MSTGHLS +LNDN+ERFREVFNEKIALIIA TDF +GT LAFYTDWRLA YG VFS G
Sbjct: 153 SMSTGHLSTILNDNLERFREVFNEKIALIIAFATDFTVGTALAFYTDWRLASYGIVFSLG 212
Query: 3141 IVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNG 2962
I SGL++S MKN +KQN H +NAGSIAFQ LG YKTV SLNGQ+QE+ERYT+ELK G
Sbjct: 213 IAFSGLINSASMMKNTDKQNAHYANAGSIAFQ-LGAYKTVCSLNGQRQEIERYTKELKEG 271
Query: 2961 EKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYC 2782
EKY L RA +S+SR YFF NALN V+LYFGANMIY+GT++ G VVR
Sbjct: 272 EKYGLYRALFYSISRGVTYFFCNALNTVVLYFGANMIYDGTLDTGTVVRD---------- 321
Query: 2781 LGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIKDTFQGIISFKNVLFSYPTR 2602
D++ DE E+ D QG ISFK+V FSYP R
Sbjct: 322 --------------------------DNEIERDEEDCEDGVDV-QGNISFKDVKFSYPIR 354
Query: 2601 PDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIK 2422
PD VLK ISF+V+ GECIALVGASGSGKSTV+QLLLHYYNI+SG I IDG ++ IN+K
Sbjct: 355 PDAQVLKGISFDVKNGECIALVGASGSGKSTVVQLLLHYYNIESGNILIDGVELNKINLK 414
Query: 2421 QLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIV 2242
+LR+ +GVV QEPVLFNT+IEENIRFG +AT EI AL+ ANA+DFVC FP GIKTIV
Sbjct: 415 KLRRVIGVVSQEPVLFNTTIEENIRFGNSEATLPEIYGALRKANAYDFVCAFPKGIKTIV 474
Query: 2241 GERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIV 2062
GERG QLSGGQKQRIAIARTLVRNP+ILLLDEATSALDNESE +VQ+AL+ AS GRTTIV
Sbjct: 475 GERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEHVVQKALENASQGRTTIV 534
Query: 2061 VAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNENEER 1882
VAHRLSTIRNANKIIVM+KGEIVEVG+H +LI+ G YN+LVQ QL+++ ++ NE
Sbjct: 535 VAHRLSTIRNANKIIVMQKGEIVEVGNHDELISKQGAYNDLVQAQLLNS-HDDHNELPPL 593
Query: 1881 VTRQSSHSDFPSNEISHQKIDQ-----EDDYVKKLIAEIKEEGAKKSNICEIIKYCRSEY 1717
RQ SH P + S Q+ DD +++L+ E+ +EGAKKSN+ EI+K CR +Y
Sbjct: 594 TARQLSHELSPLHSYSFQRSTSTDAGVHDDDMERLLDELTQEGAKKSNLREIVKMCRPDY 653
Query: 1716 CILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWALSILFLAFTRPIFI 1537
CILF+AV GSAIQGI YP+ +QL++++Y+ YA +++L+ HFWALS +FLA RP+ +
Sbjct: 654 CILFLAVFGSAIQGISYPILAQLIVRTYQGYAMHGEDILTYGHFWALSFMFLAVFRPLTL 713
Query: 1536 FFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVD 1357
+ QYY+FGK AEKLS +LR SFKH++SLP AFYDDP H+AT+LSNRLN DSSNV AAVD
Sbjct: 714 YLQYYYFGKVAEKLSTRLRVKSFKHMLSLPSAFYDDPKHSATKLSNRLNTDSSNVKAAVD 773
Query: 1356 DRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAF 1177
DRLG VIMTLVAI +AVI + Y WKM+L+VLMF PLLYLA YC + + A++EDSIAF
Sbjct: 774 DRLGCVIMTLVAISIAVITAANYCWKMTLEVLMFFPLLYLAEYCYEAATENAIQEDSIAF 833
Query: 1176 EKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYF 997
E SNR AIEALENVRTVRALN+E++V+ +T+HLQKI NSYFKRA+IQG ANG + SC+
Sbjct: 834 ENSNRTAIEALENVRTVRALNLEDKVMSSITNHLQKIHNSYFKRAIIQGAANGLSMSCFL 893
Query: 996 FIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFH 817
F+Y++SFKFG +L LR+E+ PM+TYLVLMTLSMTA+ AGSA AYLPD++KA+HAAGLIF+
Sbjct: 894 FVYSISFKFGVYLALRKEVEPMNTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFN 953
Query: 816 LFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGP 637
+FTYPA MPYDSS G++NI+ GEI +N+ F Y QR D+MIL+GV+LK+ G+TLALVGP
Sbjct: 954 MFTYPATMPYDSSDGRKNIEKGEIVGENLQFHYDQRPDRMILNGVNLKVEPGKTLALVGP 1013
Query: 636 SGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENF 457
SG GKSTIISLLERFYH +GE+KID ENV D+NLHHLR +++LVSQEP LFNCSI+EN
Sbjct: 1014 SGCGKSTIISLLERFYHVTNGEIKIDRENVEDINLHHLRANIALVSQEPTLFNCSIRENL 1073
Query: 456 LFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILR 277
L+G++ QLEI++AL+ ANAF FV QFPQGLDT+VGERGAQLSGGQKQRIAIARAILR
Sbjct: 1074 LYGLTRQVPQLEIEKALQTANAFHFVYQFPQGLDTIVGERGAQLSGGQKQRIAIARAILR 1133
Query: 276 NPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVA 97
NPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVA
Sbjct: 1134 NPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVA 1193
Query: 96 EQGTHEELLRKRSIYWRLVQKQGIQVE 16
EQGTHEELLR RS+YW LVQKQG+ V+
Sbjct: 1194 EQGTHEELLRLRSVYWGLVQKQGMHVQ 1220
>gi|17569907|ref|NP_509813.1| P-GlycoProtein related (pgp-6)
[Caenorhabditis elegans]
gi|6425208|emb|CAA94220.2| Hypothetical protein T21E8.1
[Caenorhabditis elegans]
Length = 1225
Score = 1622 bits (4199), Expect = 0.0
Identities = 834/1254 (66%), Positives = 988/1254 (78%), Gaps = 5/1254 (0%)
Frame = -1
Query: 3759 SNVCKFIKVIVGSTNNFLKKTFGFQIKCTTRYEKLLFFLGVVFSILTGMCQPFESYTLGE 3580
S +C FI+V+ KC++ +EK LF LGV+FS++TG CQPF SYT GE
Sbjct: 22 SQICSFIRVV---------------FKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGE 66
Query: 3579 TSQVLVKVTNAINNKTIDPVDLAHAYKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKF 3400
SQVLV +TNAINNKTIDP DL AY+ +E MN+VV FFL G AYF F LQ +IMK+
Sbjct: 67 VSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKY 126
Query: 3399 VGDNTAYNVRRQYISRLLRKDISYFDGMSTGHLSIVLNDNMERFREVFNEKIALIIALLT 3220
VGDNT Y VR+QYISRLL+KD YFD +STGHLS VLNDN+ERFREVFNEKIALIIA +T
Sbjct: 127 VGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVT 186
Query: 3219 DFVIGTILAFYTDWRLACYGTVFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQAL 3040
DF +GT LAFYTDWRLA YG FS GI SG ++S G MK KQN H +NAGSIAFQ L
Sbjct: 187 DFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTL 246
Query: 3039 GCYKTVSSLNGQQQEVERYTEELKNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGA 2860
G YKTV SLNGQ+ E+ERYTEELK GEKY + RA ++S+SR YFF N+LN V+LY GA
Sbjct: 247 GAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGA 306
Query: 2859 NMIYEGTIEPGVVVRILYYILFGSYCLGEAILHISRLASAIPLTVPIADILLDSDATADE 2680
MIY GT+E VVVR D +++ D T
Sbjct: 307 TMIYSGTLETAVVVR--------------------------------DDNVIEKDET--- 331
Query: 2679 FFSEEIKDTFQGIISFKNVLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQ 2500
+++ G ISFKNV FSYPTRPD VLK ISF+VQ GECIALVGASGSGKSTV+Q
Sbjct: 332 --DYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQ 389
Query: 2499 LLLHYYNIDSGRISIDGNDIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQ 2320
LLLHYYNIDSG I IDG D+ ++NIK+LR+ +GVV QEPVLFNT+IEENIRFG P+ +
Sbjct: 390 LLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLP 449
Query: 2319 EIIDALKNANAFDFVCNFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEAT 2140
EI AL+ ANA+DFVC+FP GIKTIVGERG QLSGGQKQRIAIARTLVRNP+ILLLDEAT
Sbjct: 450 EIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEAT 509
Query: 2139 SALDNESEFIVQEALQKASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAM 1960
SALDNESE +VQ+AL+ AS GRTTIVVAHRLSTIRNA+KIIVM+KGEIVEVG+H +LIA
Sbjct: 510 SALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAK 569
Query: 1959 NGVYNNLVQTQLMSTNYEKMNENEERVTRQSSHSDFPSNEISHQKIDQED-----DYVKK 1795
GVYN+LVQ QL+ + ++ E RQ S P + + Q+ D D +++
Sbjct: 570 RGVYNDLVQAQLLES-HDDHEELPPLAARQLSQELSPLHSYAIQRSTSNDAGVHDDDMER 628
Query: 1794 LIAEIKEEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFD 1615
++ E+ +EGAKKSN+ EI+K CR +YC LFIAV GSAIQG+ YP+ +QL++++YE +A
Sbjct: 629 ILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMI 688
Query: 1614 KDEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFY 1435
++ML SH WALS +FLA RP+ ++ QYY+FGK +E+LS +LR SF H++SLPCAFY
Sbjct: 689 GEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFY 748
Query: 1434 DDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMF 1255
DDP H+ATRLSNRLN DSSNV AAVDDRLG VIMT+VAI +A+ + Y WKM+L+VLMF
Sbjct: 749 DDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMF 808
Query: 1254 CPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHL 1075
PLLYLA YC + + A++ED+IAFE SNR AIEALENVRTVRALN+E++++ L++ HL
Sbjct: 809 FPLLYLAEYCYEAATETAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHL 868
Query: 1074 QKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMT 895
QKI SYFKRA+IQG ANG + SC+ F+Y+VSFKFGT+L LR+E+ PMDTYLVLMTLSMT
Sbjct: 869 QKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMT 928
Query: 894 ASYAGSAVAYLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYA 715
A+ AGSA AYLPD++KA+HAAGLIFHLFTYPA MP+ SS GK+NI+ GEI +NV F Y
Sbjct: 929 ANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGENVQFHYD 988
Query: 714 QRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVN 535
QR D+MIL+GV+LK+ G+TLALVGPSG GKSTIISLLERFYHAVDGEVKID ENV D+N
Sbjct: 989 QRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDIN 1048
Query: 534 LHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLD 355
L+HLR +++LVSQEP LFNCSI+EN L+G++ + QLE+++AL+ ANAF+FV QFPQGLD
Sbjct: 1049 LNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLD 1108
Query: 354 TLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLS 175
TLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLS
Sbjct: 1109 TLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLS 1168
Query: 174 TVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQVET 13
TVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQVET
Sbjct: 1169 TVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQVET 1222
>gi|7508148|pir||T25082 hypothetical protein T21E8.2 - Caenorhabditis
elegans
Length = 1158
Score = 1462 bits (3784), Expect = 0.0
Identities = 739/1142 (64%), Positives = 904/1142 (78%), Gaps = 12/1142 (1%)
Frame = -1
Query: 3753 VCKFIKVIVGSTNNFLKKTFGFQIKCTTRYEKLLFFLGVVFSILTGMCQPFESYTLGETS 3574
+C FI+VI KCT+ +EK LF +GV FS++TG+CQPF SYTLGET+
Sbjct: 24 LCSFIRVI---------------FKCTSCFEKFLFLIGVFFSLVTGLCQPFVSYTLGETA 68
Query: 3573 QVLVKVTNAINNKTIDPVDLAHAYKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVG 3394
QVLV +TNAINNKTIDP DL AY+ +E M +VVL FFL G AYFTF +Q +IMK+VG
Sbjct: 69 QVLVTITNAINNKTIDPADLKKAYEQYERGMYQVVLYFFLCGCAYFTFASIQHAIMKYVG 128
Query: 3393 DNTAYNVRRQYISRLLRKDISYFDGMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDF 3214
DNT Y VR+QYISRLLRKD YFD +STGHLS VLNDN+ERFREVFNEKIALI ALLTDF
Sbjct: 129 DNTTYRVRKQYISRLLRKDAEYFDNVSTGHLSTVLNDNLERFREVFNEKIALIFALLTDF 188
Query: 3213 VIGTILAFYTDWRLACYGTVFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGC 3034
V+GT LAFYTDWRLA YG FS GI SG ++S G MK KQN H +NAGSIAFQ LG
Sbjct: 189 VVGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGA 248
Query: 3033 YKTVSSLNGQQQEVERYTEELKNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANM 2854
YKTV SLNGQ E+ERYTEELK GEKY ++RA ++S+SR YFF N+LN VILY GANM
Sbjct: 249 YKTVCSLNGQNTEIERYTEELKAGEKYGIHRALMYSISRGFTYFFCNSLNTVILYVGANM 308
Query: 2853 IYEGTIEPGVVVRILYYILFGSYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFF 2674
IY G++EP VVVRI +Y++FG++CL EA+ HISRLA AI T PIA++L+ D ++
Sbjct: 309 IYSGSLEPAVVVRIFHYMMFGAFCLSEALPHISRLAGAISSTAPIAEMLIKEDNVIEKDE 368
Query: 2673 SE-EIKDTFQGIISFKNVLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQL 2497
++ +++ G ISFKNV FSYPTRPD VLK ISF+VQ GECIALVGASGSGKSTV+QL
Sbjct: 369 TDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQL 428
Query: 2496 LLHYYNIDSGRISIDGNDIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQE 2317
LLHYYNIDSG I IDG D+ ++NIK+LR+ +GVV QEPVLFNT+IEENIRFG P+ + E
Sbjct: 429 LLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPE 488
Query: 2316 IIDALKNANAFDFVCNFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATS 2137
I AL+ ANA+DFVC+FP GIKTIVGERG QLSGGQKQRIAIARTLVRNP+ILLLDEATS
Sbjct: 489 IYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATS 548
Query: 2136 ALDNESEFIVQEALQKASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMN 1957
ALDNESE +VQ+AL+ AS GRTTIVVAHRLSTIRNA+KIIVM+KGEIVEVG+H +LIA
Sbjct: 549 ALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKR 608
Query: 1956 GVYNNLVQTQLMSTNYEKMNENEERVTRQSSHSDFPSNEISHQKIDQED-----DYVKKL 1792
GVYN+LVQ QL+ + ++ E RQ S P + + Q+ D D ++++
Sbjct: 609 GVYNDLVQAQLLES-HDDHEELPPLAARQLSQELSPLHSYAIQRSTSNDAGVHDDDMERI 667
Query: 1791 IAEIKEEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDK 1612
+ E+ +EGAKKSN+ EI+K CR +YC LFIAV GSAIQG+ YP+ +QL++++YE +A
Sbjct: 668 LDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIG 727
Query: 1611 DEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYD 1432
++ML SH WALS +FLA RP+ ++ QYY+FGK +E+LS +LR SF H++SLPCAFYD
Sbjct: 728 EDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYD 787
Query: 1431 DPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFC 1252
DP H+ATRLSNRLN DSSNV AAVDDRLG VIMT+VAI +A+ + Y WKM+L+VL+F
Sbjct: 788 DPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLIFF 847
Query: 1251 PLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQ 1072
PLLYLA YC D + +++ED+IAFE SNR AIEALEN+RTVRALN+E++++ L++ HLQ
Sbjct: 848 PLLYLAEYCYDAATETSIQEDTIAFENSNRTAIEALENMRTVRALNLEDKIMSLISEHLQ 907
Query: 1071 KIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTA 892
KI SYFKRA+IQG ANG + SCY F+Y+VSFKFGT+L LR+E+ PMDTYL+L TLSMTA
Sbjct: 908 KIHKSYFKRAIIQGAANGLSLSCYLFVYSVSFKFGTYLALRKEVAPMDTYLILETLSMTA 967
Query: 891 SYAGSAVAYLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQ 712
+ AGSA AYLPD++KA+HAAGLIFHLFTYPA MP+ SS GK+NI+ GEI +NV F Y Q
Sbjct: 968 NMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQ 1027
Query: 711 RSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEV------KIDEEN 550
R D+MIL+GV+LK+ G+TLALVGPSG GKSTIISLLERFYHAVDGEV KID EN
Sbjct: 1028 RPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVVSIDAHKIDSEN 1087
Query: 549 VVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQF 370
V D+NL+HLR +++LVSQEP LFNCSI+EN L+G++ + QLE+++AL+ ANAF+FV QF
Sbjct: 1088 VEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQF 1147
Query: 369 PQ 364
PQ
Sbjct: 1148 PQ 1149
Score = 291 bits (745), Expect = 8e-77
Identities = 200/631 (31%), Positives = 316/631 (49%), Gaps = 34/631 (5%)
Frame = -1
Query: 1821 DQEDDYVKKLIAEIKEEGAKKSNICEIIKY---CRS--EYCILFIAVLGSAIQGIYYPLS 1657
+ +DY LIA+ E+ K +C I+ C S E + I V S + G+ P
Sbjct: 3 ESSNDYTTPLIAQSNEK--KPLELCSFIRVIFKCTSCFEKFLFLIGVFFSLVTGLCQPFV 60
Query: 1656 S-------QLMI-----------------KSYEAYAFDKDEMLSKSHFWALSILFLAFTR 1549
S Q+++ K+YE Y +++ +F+ + F
Sbjct: 61 SYTLGETAQVLVTITNAINNKTIDPADLKKAYEQYERGMYQVVL--YFFLCGCAYFTFAS 118
Query: 1548 PIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVT 1369
Q+ + + ++R L+ ++D+ + LS LN +
Sbjct: 119 -----IQHAIMKYVGDNTTYRVRKQYISRLLRKDAEYFDNV--STGHLSTVLNDNLERFR 171
Query: 1368 AAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEED 1189
++++ + L ++ ++F+ W+++ + F + +G+ N V + +
Sbjct: 172 EVFNEKIALIFALLTDFVVGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQ 231
Query: 1188 SIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFAC 1009
+ + + A + L +TV +LN +N I T L+ RA++ + GF
Sbjct: 232 NTHYANAGSIAFQTLGAYKTVCSLNGQNTEIERYTEELKAGEKYGIHRALMYSISRGFT- 290
Query: 1008 SCYFF---IYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIH 838
YFF + V G ++ + P + + A A+ ++ AI
Sbjct: 291 --YFFCNSLNTVILYVGANMIYSGSLEPAVVVRIFHYMMFGAFCLSEALPHISRLAGAIS 348
Query: 837 AAGLIFH-LFTYPAIMPYDSSQGKRNIK-NGEIELKNVSFEYAQRSDKMILDGVSLKLPA 664
+ I L ++ D + ++ NG I KNV F Y R D +L G+S +
Sbjct: 349 STAPIAEMLIKEDNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQN 408
Query: 663 GRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVL 484
G +ALVG SGSGKST++ LL +Y+ G + ID ++ D+N+ LR + +VSQEPVL
Sbjct: 409 GECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVL 468
Query: 483 FNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQR 304
FN +I+EN FG + N S EI AL+ ANA+ FV FP+G+ T+VGERG QLSGGQKQR
Sbjct: 469 FNTTIEENIRFG-NPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQR 527
Query: 303 IAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSI 124
IAIAR ++RNPK+LLLDEATSALD++SE+VVQ AL+ AS+ +T+VVAHRLST+ NA I
Sbjct: 528 IAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKI 587
Query: 123 AVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
V++ G++ E G H+EL+ KR +Y LVQ Q
Sbjct: 588 IVMQKGEIVEVGNHDELIAKRGVYNDLVQAQ 618
>gi|25146777|ref|NP_509811.2| P-GlycoProtein related (pgp-8)
[Caenorhabditis elegans]
gi|22265670|emb|CAA94203.2| Hypothetical protein T21E8.3
[Caenorhabditis elegans]
gi|22265925|emb|CAA94221.2| Hypothetical protein T21E8.3
[Caenorhabditis elegans]
Length = 1243
Score = 1431 bits (3703), Expect = 0.0
Identities = 727/1252 (58%), Positives = 948/1252 (75%), Gaps = 6/1252 (0%)
Frame = -1
Query: 3768 TNWSNVCKFIKVIVGSTNNFLKKTFGFQIKCTTRYEKLLFFLGVVFSILTGMCQPFESYT 3589
TNW+ KF+KV+ +CT+++EK LF +GVV +I TG+ QPF SYT
Sbjct: 19 TNWT---KFVKVVW---------------QCTSKWEKFLFVIGVVSAICTGLTQPFMSYT 60
Query: 3588 LGETSQVLVKVTNAINNKTIDPVDLAHAYKLFESDMNRVVLLFFLVGFAYFTFGFLQFSI 3409
GE SQ V++T A+NN ++DP DL AY++F +DMN VV+ F LVG A+ FGF+QFS+
Sbjct: 61 FGEVSQAFVRITAAVNNASLDPSDLEKAYEMFHADMNNVVIHFGLVGCAFMFFGFIQFSL 120
Query: 3408 MKFVGDNTAYNVRRQYISRLLRKDISYFDGMSTGHLSIVLNDNMERFREVFNEKIALIIA 3229
K++GDNT Y +R ++I RLL+KD YFD +STG+LS VLNDN+ERFRE FNEKIA II
Sbjct: 121 FKYIGDNTTYRLRHKFILRLLKKDAKYFDTISTGYLSTVLNDNLERFREAFNEKIAFIIC 180
Query: 3228 LLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAF 3049
TDF IGT LAFYT W LA YG+VF+FGIV+SGLL+S MK+NEKQ+ H SNAG+IAF
Sbjct: 181 FSTDFAIGTALAFYTSWTLASYGSVFAFGIVISGLLNSTSMMKSNEKQSMHYSNAGAIAF 240
Query: 3048 QALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNRAFVFSLSRSADYFFTNALNFVILY 2869
QAL +KTV SLNGQ QE+E+Y+ ELK GEK+ RAF + SR +FF NALN ILY
Sbjct: 241 QALCSFKTVISLNGQTQELEKYSAELKEGEKFGSRRAFFLATSRGLSHFFCNALNGTILY 300
Query: 2868 FGANMIYEGTIEPGVVVRILYYILFGSYCLGEAILHISRLASAIPLTVPIADILLDSDAT 2689
GA++IY T+ +V + +Y+LF ++ LGEA LHIS L +AI PI D+L D
Sbjct: 301 VGADLIYNKTMNTVAIVTLFHYMLFSAFSLGEAFLHISYLLNAINSATPIFDVLTSDDDM 360
Query: 2688 ADEFFSEEIKD---TFQGIISFKNVLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSG 2518
+ E D T QG++SF NV F+YP+RPDV +L+ ISF+V+ GECIALVGASGSG
Sbjct: 361 IENNQDNEQTDSNKTIQGMLSFNNVKFAYPSRPDVDILRGISFDVKQGECIALVGASGSG 420
Query: 2517 KSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGK 2338
KST++QLLLH+YNI SG I I + +++IN+KQLR A+GVV QEPVLFNT+IEENIRFG
Sbjct: 421 KSTIVQLLLHFYNIQSGTIKIGDSHLHDINLKQLRNAIGVVSQEPVLFNTTIEENIRFGN 480
Query: 2337 PDATEQEIIDALKNANAFDFVCNFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRIL 2158
P+AT EI +AL+ ANA+DFVCN DG+KTIVGERGAQLSGGQKQRIAIAR LV+NP IL
Sbjct: 481 PNATSSEIYEALRKANAYDFVCNIKDGLKTIVGERGAQLSGGQKQRIAIARVLVKNPAIL 540
Query: 2157 LLDEATSALDNESEFIVQEALQKASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDH 1978
LLDEATSALD+ SE VQ AL+KAS GRTTI++AHRLSTIR+ +KI+VM G+I EVG H
Sbjct: 541 LLDEATSALDSASERAVQLALKKASEGRTTIIIAHRLSTIRHCDKIMVMSNGKIAEVGSH 600
Query: 1977 KQLIAMNGVYNNLVQTQLMSTNY--EKMN-ENEERVTRQSSHSDFPSNEISHQKIDQEDD 1807
++LI+M+ Y+NLV+ Q + E +N + E V +++ P N + +
Sbjct: 601 EELISMDREYSNLVRAQFFDSQSVEEDINGQGAEEVIQKT-----PPNL-------NDGE 648
Query: 1806 YVKKLIAEIKEEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEA 1627
+++L+ E + KSNI E+++ CR + +L +AV+GSAIQG +P+ SQ+++++Y+A
Sbjct: 649 PLEELLKETSSDIEIKSNIWEVLRECRPDAFLLSMAVIGSAIQGCNFPILSQIIVQTYKA 708
Query: 1626 YAFDKDEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLP 1447
YA D + +L+ HFWA L L RPI ++ Q++FFGK +EKLS +LR SF+HL+SLP
Sbjct: 709 YAMDGENILTYGHFWAAMFLVLGVIRPITLYCQFFFFGKVSEKLSTRLRIKSFQHLLSLP 768
Query: 1446 CAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQ 1267
CAFYDDP H+ TRL NRLN D SN+ AAVD RLGS++M++V+ LA++++ +YSWK++LQ
Sbjct: 769 CAFYDDPKHSPTRLVNRLNTDPSNIKAAVDARLGSLLMSMVSFSLAILIACYYSWKLTLQ 828
Query: 1266 VLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLV 1087
V++F P+LY A + +++EDS+AFE SN+ AIE L+N++TV+ALNME RVI LV
Sbjct: 829 VVLFFPVLYYAKFLYKKTTTISIKEDSVAFENSNKIAIEVLDNMKTVKALNMEARVINLV 888
Query: 1086 TSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMT 907
+L ++ SY +R+V+ G ANGF+ C +YA+SFKFGT+L+L++E++PMD YL L+T
Sbjct: 889 MEYLAVLKTSYPRRSVVMGLANGFSAGCSQIVYAISFKFGTYLILQKEVIPMDMYLSLIT 948
Query: 906 LSMTASYAGSAVAYLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVS 727
LS T++ AGSA++Y+PD RKAIH+AGLIF+LFTYPA MP++S G R+I GE+ +NV
Sbjct: 949 LSYTSNMAGSAISYMPDFRKAIHSAGLIFNLFTYPATMPFNSDTGSRSITKGEVNGENVK 1008
Query: 726 FEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENV 547
F Y QR D +LD V+LK+ AG+TLA+VGPSGSGKSTIISLLE FY A G +KID +NV
Sbjct: 1009 FHYHQRPDYTVLDSVNLKVEAGKTLAIVGPSGSGKSTIISLLEMFYRADQGFIKIDNDNV 1068
Query: 546 VDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFP 367
++NL HLR ++ LVSQ PVLFNCSI++N L+G++ N SQ EI+ AL++ANAF+FV Q P
Sbjct: 1069 ENINLDHLRSNLGLVSQGPVLFNCSIRDNILYGLTRNISQTEIENALQIANAFNFVFQLP 1128
Query: 366 QGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTAS 187
QGLDT+VG+RGAQLSGGQKQRIAI RAILRNPK+LLLDEATSALD++SEK+VQNALDTAS
Sbjct: 1129 QGLDTIVGDRGAQLSGGQKQRIAITRAILRNPKLLLLDEATSALDTESEKIVQNALDTAS 1188
Query: 186 ERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
ERLST+VVAHRLST++NADSIAVL+NGKV EQGTH +LL + YWRLVQ Q
Sbjct: 1189 ERLSTIVVAHRLSTIINADSIAVLRNGKVVEQGTHNQLLAVKGDYWRLVQHQ 1240
Score = 293 bits (751), Expect = 2e-77
Identities = 192/556 (34%), Positives = 306/556 (54%), Gaps = 10/556 (1%)
Frame = -1
Query: 1641 KSYEAYAFDKDEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKH 1462
K+YE + D + ++ HF + F+ F F Q+ F + + +LR
Sbjct: 87 KAYEMFHADMNNVVI--HFGLVGCAFMFFG-----FIQFSLFKYIGDNTTYRLRHKFILR 139
Query: 1461 LMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSW 1282
L+ ++D + LS LN + A ++++ +I + ++F+ SW
Sbjct: 140 LLKKDAKYFDTI--STGYLSTVLNDNLERFREAFNEKIAFIICFSTDFAIGTALAFYTSW 197
Query: 1281 KMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENR 1102
++ +F + ++G N + ++ E+ S+ + + A +AL + +TV +LN + +
Sbjct: 198 TLASYGSVFAFGIVISGLLNSTSMMKSNEKQSMHYSNAGAIAFQALCSFKTVISLNGQTQ 257
Query: 1101 VILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEIL---PM 931
+ ++ L++ +RA T+ G + +FF A++ GT L + +++ M
Sbjct: 258 ELEKYSAELKEGEKFGSRRAFFLATSRGLS---HFFCNALN---GTILYVGADLIYNKTM 311
Query: 930 DTYLVLMT---LSMTASYAGSAVAYLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGKRNI 760
+T ++ + +A G A ++ AI++A IF + T M ++ ++
Sbjct: 312 NTVAIVTLFHYMLFSAFSLGEAFLHISYLLNAINSATPIFDVLTSDDDMIENNQDNEQTD 371
Query: 759 KN----GEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERF 592
N G + NV F Y R D IL G+S + G +ALVG SGSGKSTI+ LL F
Sbjct: 372 SNKTIQGMLSFNNVKFAYPSRPDVDILRGISFDVKQGECIALVGASGSGKSTIVQLLLHF 431
Query: 591 YHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQ 412
Y+ G +KI + ++ D+NL LR ++ +VSQEPVLFN +I+EN FG + NA+ EI +
Sbjct: 432 YNIQSGTIKIGDSHLHDINLKQLRNAIGVVSQEPVLFNTTIEENIRFG-NPNATSSEIYE 490
Query: 411 ALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALD 232
AL+ ANA+ FV GL T+VGERGAQLSGGQKQRIAIAR +++NP +LLLDEATSALD
Sbjct: 491 ALRKANAYDFVCNIKDGLKTIVGERGAQLSGGQKQRIAIARVLVKNPAILLLDEATSALD 550
Query: 231 SDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIY 52
S SE+ VQ AL ASE +T+++AHRLST+ + D I V+ NGK+AE G+HEEL+ Y
Sbjct: 551 SASERAVQLALKKASEGRTTIIIAHRLSTIRHCDKIMVMSNGKIAEVGSHEELISMDREY 610
Query: 51 WRLVQKQGIQVETLIE 4
LV+ Q +++ E
Sbjct: 611 SNLVRAQFFDSQSVEE 626
Score = 278 bits (712), Expect = 6e-73
Identities = 186/543 (34%), Positives = 282/543 (51%), Gaps = 10/543 (1%)
Frame = -1
Query: 3516 LAHAYKLFESDMNRVVL-------LFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYI 3358
+ YK + D ++ +F ++G + QF V + + +R +
Sbjct: 702 IVQTYKAYAMDGENILTYGHFWAAMFLVLGVIRPITLYCQFFFFGKVSEKLSTRLRIKSF 761
Query: 3357 SRLLRKDISYFDGMSTGHLSIV--LNDNMERFREVFNEKIALIIALLTDFVIGTILAFYT 3184
LL +++D +V LN + + + ++ ++ + F + ++A Y
Sbjct: 762 QHLLSLPCAFYDDPKHSPTRLVNRLNTDPSNIKAAVDARLGSLLMSMVSFSLAILIACYY 821
Query: 3183 DWRLACYGTVFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQ 3004
W+L +F + + L + ++ + N+ IA + L KTV +LN +
Sbjct: 822 SWKLTLQVVLFFPVLYYAKFLYKKTTTISIKEDSVAFENSNKIAIEVLDNMKTVKALNME 881
Query: 3003 QQEVERYTEELKNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGV 2824
+ + E L + R+ V L+ + + + FG +I + + P
Sbjct: 882 ARVINLVMEYLAVLKTSYPRRSVVMGLANGFSAGCSQIVYAISFKFGTYLILQKEVIPMD 941
Query: 2823 VVRILYYILFGSYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIKDTFQG 2644
+ L + + S G AI ++ AI I + L AT + +G
Sbjct: 942 MYLSLITLSYTSNMAGSAISYMPDFRKAIHSAGLIFN-LFTYPATMPFNSDTGSRSITKG 1000
Query: 2643 IISFKNVLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGR 2464
++ +NV F Y RPD VL ++ V+ G+ +A+VG SGSGKST+I LL +Y D G
Sbjct: 1001 EVNGENVKFHYHQRPDYTVLDSVNLKVEAGKTLAIVGPSGSGKSTIISLLEMFYRADQGF 1060
Query: 2463 ISIDGNDIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKP-DATEQEIIDALKNANA 2287
I ID +++ NIN+ LR +G+V Q PVLFN SI +NI +G + ++ EI +AL+ ANA
Sbjct: 1061 IKIDNDNVENINLDHLRSNLGLVSQGPVLFNCSIRDNILYGLTRNISQTEIENALQIANA 1120
Query: 2286 FDFVCNFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIV 2107
F+FV P G+ TIVG+RGAQLSGGQKQRIAI R ++RNP++LLLDEATSALD ESE IV
Sbjct: 1121 FNFVFQLPQGLDTIVGDRGAQLSGGQKQRIAITRAILRNPKLLLLDEATSALDTESEKIV 1180
Query: 2106 QEALQKASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQ 1927
Q AL AS +TIVVAHRLSTI NA+ I V+ G++VE G H QL+A+ G Y LVQ Q
Sbjct: 1181 QNALDTASERLSTIVVAHRLSTIINADSIAVLRNGKVVEQGTHNQLLAVKGDYWRLVQHQ 1240
Query: 1926 LMS 1918
S
Sbjct: 1241 KSS 1243
>gi|7511495|pir||T18940 multidrug resistance protein homolog -
Caenorhabditis elegans
Length = 1238
Score = 1418 bits (3670), Expect = 0.0
Identities = 724/1252 (57%), Positives = 943/1252 (74%), Gaps = 6/1252 (0%)
Frame = -1
Query: 3768 TNWSNVCKFIKVIVGSTNNFLKKTFGFQIKCTTRYEKLLFFLGVVFSILTGMCQPFESYT 3589
TNW+ KF+KV+ +CT+++EK LF +GVV +I TG+ QPF SYT
Sbjct: 19 TNWT---KFVKVVW---------------QCTSKWEKFLFVIGVVSAICTGLTQPFMSYT 60
Query: 3588 LGETSQVLVKVTNAINNKTIDPVDLAHAYKLFESDMNRVVLLFFLVGFAYFTFGFLQFSI 3409
GE SQ V++T A+NN ++DP DL AY++F +DMN VV+ F LVG A+ FGF+QFS+
Sbjct: 61 FGEVSQAFVRITAAVNNASLDPSDLEKAYEMFHADMNNVVIHFGLVGCAFMFFGFIQFSL 120
Query: 3408 MKFVGDNTAYNVRRQYISRLLRKDISYFDGMSTGHLSIVLNDNMERFREVFNEKIALIIA 3229
K++GDNT Y +R ++I RLL+KD YFD +STG+LS VLNDN+ERFRE FNEKIA II
Sbjct: 121 FKYIGDNTTYRLRHKFILRLLKKDAKYFDTISTGYLSTVLNDNLERFREAFNEKIAFIIC 180
Query: 3228 LLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAF 3049
TDF IGT LAFYT W LA YG+VF+FGIV+SGLL+S MK+NEKQ+ H SNAG+IAF
Sbjct: 181 FSTDFAIGTALAFYTSWTLASYGSVFAFGIVISGLLNSTSMMKSNEKQSMHYSNAGAIAF 240
Query: 3048 QALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNRAFVFSLSRSADYFFTNALNFVILY 2869
QAL +KTV SLNGQ QE+E+Y+ ELK GEK+ RAF + SR +FF NALN ILY
Sbjct: 241 QALCSFKTVISLNGQTQELEKYSAELKEGEKFGSRRAFFLATSRGLSHFFCNALNGTILY 300
Query: 2868 FGANMIYEGTIEPGVVVRILYYILFGSYCLGEAILHISRLASAIPLTVPIADILLDSDAT 2689
GA++IY T+ +V + +Y+LF ++ LGEA LHIS L +AI PI D+L D
Sbjct: 301 VGADLIYNKTMNTVAIVTLFHYMLFSAFSLGEAFLHISYLLNAINSATPIFDVLTSDDDM 360
Query: 2688 ADEFFSEEIKD---TFQGIISFKNVLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSG 2518
+ E D T QG++SF NV F+YP+RPDV +L+ ISF+V+ GECIALVGASGSG
Sbjct: 361 IENNQDNEQTDSNKTIQGMLSFNNVKFAYPSRPDVDILRGISFDVKQGECIALVGASGSG 420
Query: 2517 KSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGK 2338
KST++QLLLH+YNI SG I I + +++IN+KQLR A+GVV QEPVLFNT+IEENIRFG
Sbjct: 421 KSTIVQLLLHFYNIQSGTIKIGDSHLHDINLKQLRNAIGVVSQEPVLFNTTIEENIRFGN 480
Query: 2337 PDATEQEIIDALKNANAFDFVCNFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRIL 2158
P+AT EI +AL+ ANA+DFVCN DG+KTIVGERGAQLSGGQKQRIAIAR LV+NP IL
Sbjct: 481 PNATSSEIYEALRKANAYDFVCNIKDGLKTIVGERGAQLSGGQKQRIAIARVLVKNPAIL 540
Query: 2157 LLDEATSALDNESEFIVQEALQKASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDH 1978
LLDEATSALD+ SE VQ AL+KAS GRTTI++AHRLSTIR+ +KI+VM G+I EVG H
Sbjct: 541 LLDEATSALDSASERAVQLALKKASEGRTTIIIAHRLSTIRHCDKIMVMSNGKIAEVGSH 600
Query: 1977 KQLIAMNGVYNNLVQTQLMSTNY--EKMN-ENEERVTRQSSHSDFPSNEISHQKIDQEDD 1807
++LI+M+ Y+NLV+ Q + E +N + E V +++ P N + +
Sbjct: 601 EELISMDREYSNLVRAQFFDSQSVEEDINGQGAEEVIQKT-----PPNL-------NDGE 648
Query: 1806 YVKKLIAEIKEEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEA 1627
+++L+ E + KSNI E+++ CR + +L +AV+GSAIQG +P+ SQ+++++Y+A
Sbjct: 649 PLEELLKETSSDIEIKSNIWEVLRECRPDAFLLSMAVIGSAIQGCNFPILSQIIVQTYKA 708
Query: 1626 YAFDKDEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLP 1447
YA D + +L+ HFWA L L RPI ++ Q++FFGK +EKLS +LR SF+HL+SLP
Sbjct: 709 YAMDGENILTYGHFWAAMFLVLGVIRPITLYCQFFFFGKVSEKLSTRLRIKSFQHLLSLP 768
Query: 1446 CAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQ 1267
CAFYDDP H+ TRL NRLN D SN+ AAVD RLGS++M++V+ LA++++ +YSWK++LQ
Sbjct: 769 CAFYDDPKHSPTRLVNRLNTDPSNIKAAVDARLGSLLMSMVSFSLAILIACYYSWKLTLQ 828
Query: 1266 VLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLV 1087
+ LY A + +++EDS+AFE SN+ AIE L+N++TV+ALNME RVI LV
Sbjct: 829 AI-----LYYAKFLYKKTTTISIKEDSVAFENSNKIAIEVLDNMKTVKALNMEARVINLV 883
Query: 1086 TSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMT 907
+L ++ SY +R+V+ G ANGF+ C +YA+SFKFGT+L+L++E++PMD YL L+T
Sbjct: 884 MEYLAVLKTSYPRRSVVMGLANGFSAGCSQIVYAISFKFGTYLILQKEVIPMDMYLSLIT 943
Query: 906 LSMTASYAGSAVAYLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVS 727
LS T++ AGSA++Y+PD RKAIH+AGLIF+LFTYPA MP++S G R+I GE+ +NV
Sbjct: 944 LSYTSNMAGSAISYMPDFRKAIHSAGLIFNLFTYPATMPFNSDTGSRSITKGEVNGENVK 1003
Query: 726 FEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENV 547
F Y QR D +LD V+LK+ AG+TLA+VGPSGSGKSTIISLLE FY A G +KID +NV
Sbjct: 1004 FHYHQRPDYTVLDSVNLKVEAGKTLAIVGPSGSGKSTIISLLEMFYRADQGFIKIDNDNV 1063
Query: 546 VDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFP 367
++NL HLR ++ LVSQ PVLFNCSI++N L+G++ N SQ EI+ AL++ANAF+FV Q P
Sbjct: 1064 ENINLDHLRSNLGLVSQGPVLFNCSIRDNILYGLTRNISQTEIENALQIANAFNFVFQLP 1123
Query: 366 QGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTAS 187
QGLDT+VG+RGAQLSGGQKQRIAI RAILRNPK+LLLDEATSALD++SEK+VQNALDTAS
Sbjct: 1124 QGLDTIVGDRGAQLSGGQKQRIAITRAILRNPKLLLLDEATSALDTESEKIVQNALDTAS 1183
Query: 186 ERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
ERLST+VVAHRLST++NADSIAVL+NGKV EQGTH +LL + YWRLVQ Q
Sbjct: 1184 ERLSTIVVAHRLSTIINADSIAVLRNGKVVEQGTHNQLLAVKGDYWRLVQHQ 1235
Score = 293 bits (751), Expect = 2e-77
Identities = 192/556 (34%), Positives = 306/556 (54%), Gaps = 10/556 (1%)
Frame = -1
Query: 1641 KSYEAYAFDKDEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKH 1462
K+YE + D + ++ HF + F+ F F Q+ F + + +LR
Sbjct: 87 KAYEMFHADMNNVVI--HFGLVGCAFMFFG-----FIQFSLFKYIGDNTTYRLRHKFILR 139
Query: 1461 LMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSW 1282
L+ ++D + LS LN + A ++++ +I + ++F+ SW
Sbjct: 140 LLKKDAKYFDTI--STGYLSTVLNDNLERFREAFNEKIAFIICFSTDFAIGTALAFYTSW 197
Query: 1281 KMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENR 1102
++ +F + ++G N + ++ E+ S+ + + A +AL + +TV +LN + +
Sbjct: 198 TLASYGSVFAFGIVISGLLNSTSMMKSNEKQSMHYSNAGAIAFQALCSFKTVISLNGQTQ 257
Query: 1101 VILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEIL---PM 931
+ ++ L++ +RA T+ G + +FF A++ GT L + +++ M
Sbjct: 258 ELEKYSAELKEGEKFGSRRAFFLATSRGLS---HFFCNALN---GTILYVGADLIYNKTM 311
Query: 930 DTYLVLMT---LSMTASYAGSAVAYLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGKRNI 760
+T ++ + +A G A ++ AI++A IF + T M ++ ++
Sbjct: 312 NTVAIVTLFHYMLFSAFSLGEAFLHISYLLNAINSATPIFDVLTSDDDMIENNQDNEQTD 371
Query: 759 KN----GEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERF 592
N G + NV F Y R D IL G+S + G +ALVG SGSGKSTI+ LL F
Sbjct: 372 SNKTIQGMLSFNNVKFAYPSRPDVDILRGISFDVKQGECIALVGASGSGKSTIVQLLLHF 431
Query: 591 YHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQ 412
Y+ G +KI + ++ D+NL LR ++ +VSQEPVLFN +I+EN FG + NA+ EI +
Sbjct: 432 YNIQSGTIKIGDSHLHDINLKQLRNAIGVVSQEPVLFNTTIEENIRFG-NPNATSSEIYE 490
Query: 411 ALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALD 232
AL+ ANA+ FV GL T+VGERGAQLSGGQKQRIAIAR +++NP +LLLDEATSALD
Sbjct: 491 ALRKANAYDFVCNIKDGLKTIVGERGAQLSGGQKQRIAIARVLVKNPAILLLDEATSALD 550
Query: 231 SDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIY 52
S SE+ VQ AL ASE +T+++AHRLST+ + D I V+ NGK+AE G+HEEL+ Y
Sbjct: 551 SASERAVQLALKKASEGRTTIIIAHRLSTIRHCDKIMVMSNGKIAEVGSHEELISMDREY 610
Query: 51 WRLVQKQGIQVETLIE 4
LV+ Q +++ E
Sbjct: 611 SNLVRAQFFDSQSVEE 626
Score = 275 bits (703), Expect = 6e-72
Identities = 185/543 (34%), Positives = 281/543 (51%), Gaps = 10/543 (1%)
Frame = -1
Query: 3516 LAHAYKLFESDMNRVVL-------LFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYI 3358
+ YK + D ++ +F ++G + QF V + + +R +
Sbjct: 702 IVQTYKAYAMDGENILTYGHFWAAMFLVLGVIRPITLYCQFFFFGKVSEKLSTRLRIKSF 761
Query: 3357 SRLLRKDISYFDGMSTGHLSIV--LNDNMERFREVFNEKIALIIALLTDFVIGTILAFYT 3184
LL +++D +V LN + + + ++ ++ + F + ++A Y
Sbjct: 762 QHLLSLPCAFYDDPKHSPTRLVNRLNTDPSNIKAAVDARLGSLLMSMVSFSLAILIACYY 821
Query: 3183 DWRLACYGTVFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQ 3004
W+L ++ + L + ++ + N+ IA + L KTV +LN +
Sbjct: 822 SWKLTLQAILY-----YAKFLYKKTTTISIKEDSVAFENSNKIAIEVLDNMKTVKALNME 876
Query: 3003 QQEVERYTEELKNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGV 2824
+ + E L + R+ V L+ + + + FG +I + + P
Sbjct: 877 ARVINLVMEYLAVLKTSYPRRSVVMGLANGFSAGCSQIVYAISFKFGTYLILQKEVIPMD 936
Query: 2823 VVRILYYILFGSYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIKDTFQG 2644
+ L + + S G AI ++ AI I + L AT + +G
Sbjct: 937 MYLSLITLSYTSNMAGSAISYMPDFRKAIHSAGLIFN-LFTYPATMPFNSDTGSRSITKG 995
Query: 2643 IISFKNVLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGR 2464
++ +NV F Y RPD VL ++ V+ G+ +A+VG SGSGKST+I LL +Y D G
Sbjct: 996 EVNGENVKFHYHQRPDYTVLDSVNLKVEAGKTLAIVGPSGSGKSTIISLLEMFYRADQGF 1055
Query: 2463 ISIDGNDIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKP-DATEQEIIDALKNANA 2287
I ID +++ NIN+ LR +G+V Q PVLFN SI +NI +G + ++ EI +AL+ ANA
Sbjct: 1056 IKIDNDNVENINLDHLRSNLGLVSQGPVLFNCSIRDNILYGLTRNISQTEIENALQIANA 1115
Query: 2286 FDFVCNFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIV 2107
F+FV P G+ TIVG+RGAQLSGGQKQRIAI R ++RNP++LLLDEATSALD ESE IV
Sbjct: 1116 FNFVFQLPQGLDTIVGDRGAQLSGGQKQRIAITRAILRNPKLLLLDEATSALDTESEKIV 1175
Query: 2106 QEALQKASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQ 1927
Q AL AS +TIVVAHRLSTI NA+ I V+ G++VE G H QL+A+ G Y LVQ Q
Sbjct: 1176 QNALDTASERLSTIVVAHRLSTIINADSIAVLRNGKVVEQGTHNQLLAVKGDYWRLVQHQ 1235
Query: 1926 LMS 1918
S
Sbjct: 1236 KSS 1238
>gi|39594940|emb|CAE70808.1| Hypothetical protein CBG17570
[Caenorhabditis briggsae]
Length = 1402
Score = 1413 bits (3657), Expect = 0.0
Identities = 709/1215 (58%), Positives = 923/1215 (75%), Gaps = 2/1215 (0%)
Frame = -1
Query: 3681 KCTTRYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAY 3502
KCT++ EKLLF LG + ++ TG+CQPF SYT GE S V V++T+A+NN+T+DP +L AY
Sbjct: 30 KCTSKLEKLLFLLGTISAVCTGLCQPFLSYTFGEVSHVFVRITSAVNNRTLDPSELDEAY 89
Query: 3501 KLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFD 3322
++F ++MN+VVL F LVG A+ FGF QFS+ K+VGDNT Y VRR+YISRLL+KD YFD
Sbjct: 90 EVFHNEMNQVVLYFALVGCAFAMFGFFQFSLFKYVGDNTTYRVRRKYISRLLQKDAQYFD 149
Query: 3321 GMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFG 3142
+STG+LS VLNDN+ERFRE FNEKIA II TDFVIGT LAFYTDW+LA YG++F+ G
Sbjct: 150 TVSTGYLSTVLNDNLERFREAFNEKIAFIICFSTDFVIGTTLAFYTDWKLASYGSIFALG 209
Query: 3141 IVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNG 2962
I SG ++S M + KQN H +NAG+IAFQAL +KTV SLNGQ QE+ERY++ELK G
Sbjct: 210 IAFSGFINSASMMGSTVKQNTHYANAGAIAFQALSSFKTVISLNGQAQELERYSKELKAG 269
Query: 2961 EKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYC 2782
EKY RAF + SRS +FF NALN +ILY GA++IY T++ V+V + +Y+LF ++
Sbjct: 270 EKYGARRAFFLATSRSVTHFFCNALNGIILYVGADLIYNKTMDQAVIVTLFHYMLFSAFS 329
Query: 2781 LGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIKDT--FQGIISFKNVLFSYP 2608
LGEA HIS L++AI PI +L+ D + ++ +D+ +G I F NV FSYP
Sbjct: 330 LGEAFPHISYLSNAISSASPIFAVLISKDDIIENHQNDTERDSERIEGDIQFDNVKFSYP 389
Query: 2607 TRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNIN 2428
TRP+ LK ++FNV+ GEC+ALVGASGSGKST++QLLLHYYNI+SG I ID D+ IN
Sbjct: 390 TRPEAQALKGVTFNVKKGECVALVGASGSGKSTIVQLLLHYYNIESGNILIDDVDLNKIN 449
Query: 2427 IKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKT 2248
+K+LR +GVV QEPVLFNT+IEENIRFG P A+ EI D+L+ ANA+DFV +FP GIKT
Sbjct: 450 LKKLRGNIGVVSQEPVLFNTTIEENIRFGNPAASTLEIYDSLRVANAYDFVNSFPKGIKT 509
Query: 2247 IVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTT 2068
+VGERG QLSGGQKQRIAIAR LV+NP+ILLLDEATSALDN+SE +V+ A+++AS GRTT
Sbjct: 510 VVGERGTQLSGGQKQRIAIARVLVKNPKILLLDEATSALDNQSEHVVRIAMKEASKGRTT 569
Query: 2067 IVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNENE 1888
IV+AHRLSTI++ ++IIVM G+ V G H +L+ + VY +LVQ Q S N E +
Sbjct: 570 IVIAHRLSTIQHCDRIIVMSHGKTVASGTHDKLMENSIVYKDLVQAQ--SLNSEDSVVEK 627
Query: 1887 ERVTRQSSHSDFPSNEISHQKIDQEDDYVKKLIAEIKEEGAKKSNICEIIKYCRSEYCIL 1708
T +S + P+NE ++++E + + EE S I +I++ CRS C+L
Sbjct: 628 SIKTIATSETKHPTNE----ELEEE-------LKDTPEEETMSSTIWQILRECRSHCCML 676
Query: 1707 FIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWALSILFLAFTRPIFIFFQ 1528
F+AV+GSAIQG +P+ +QL+++ Y+AYA + +L HFWA L L RPI ++ Q
Sbjct: 677 FLAVVGSAIQGFSFPILAQLIVRVYKAYAMQGEAILVNGHFWASMFLVLGLYRPITLYCQ 736
Query: 1527 YYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRL 1348
Y+FFGK EKLS +LR SF+HL+SLPCAFYDDP ++ TRL+NRLN D+SNV AAVD RL
Sbjct: 737 YFFFGKIGEKLSTRLRIKSFQHLLSLPCAFYDDPKNSPTRLANRLNTDASNVKAAVDARL 796
Query: 1347 GSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKS 1168
GSV+MTLV+ ++A+ ++ +YSWK+++QVL+F P+LYL+ YC + ++++DS+AFE S
Sbjct: 797 GSVLMTLVSFIVAITIACYYSWKLTIQVLLFFPVLYLSKYCYEKTTVLSIKQDSLAFEFS 856
Query: 1167 NRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIY 988
N+ AIE L+N++TVR+LNME +V+ +VT L+ ++ Y KRA G A+GF+ C +Y
Sbjct: 857 NKIAIEVLDNIKTVRSLNMEQKVMSMVTGQLEMLKRKYHKRAFFLGLASGFSAGCSQIVY 916
Query: 987 AVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFHLFT 808
A+SFKFGT+L+L+ E+LPMD YL L+TLS T++ AGSA++YLPD++KA+HAAGLIF+LFT
Sbjct: 917 ALSFKFGTYLILQREVLPMDMYLALVTLSYTSNMAGSAISYLPDYKKALHAAGLIFNLFT 976
Query: 807 YPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGS 628
YPA PY+S QG NI G + +NV F Y QR D ++L V L L G+TLALVGPSGS
Sbjct: 977 YPATAPYNSDQGTTNISQGIVNAENVKFHYHQRPDHLVLKNVDLHLEPGKTLALVGPSGS 1036
Query: 627 GKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFG 448
GKST ISLLE FY G + ID ENV ++NLHHLR +++LVSQEP+LFNCSI+EN L+G
Sbjct: 1037 GKSTFISLLEMFYRVNTGHINIDHENVENINLHHLRSNLALVSQEPILFNCSIRENLLYG 1096
Query: 447 ISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPK 268
+ S ++ AL+ ANA++FVSQ P GLDT+VGERGAQLSGGQKQR+AIARAILRNPK
Sbjct: 1097 LDGPESDQNLETALETANAYNFVSQMPNGLDTIVGERGAQLSGGQKQRVAIARAILRNPK 1156
Query: 267 VLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQG 88
+LLLDEATSALDSDSEK+VQ ALDTASERLST++VAHRLST+VNADSIAVLK GKV EQG
Sbjct: 1157 LLLLDEATSALDSDSEKLVQTALDTASERLSTIIVAHRLSTIVNADSIAVLKMGKVVEQG 1216
Query: 87 THEELLRKRSIYWRL 43
+HEELL+ + YW+L
Sbjct: 1217 SHEELLKLKGAYWKL 1231
Score = 278 bits (710), Expect = 1e-72
Identities = 186/548 (33%), Positives = 300/548 (53%), Gaps = 9/548 (1%)
Frame = -1
Query: 1632 EAYAFDKDEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMS 1453
EAY +EM ++AL + AF +F FFQ+ F + + ++R L+
Sbjct: 87 EAYEVFHNEMNQVVLYFAL--VGCAFA--MFGFFQFSLFKYVGDNTTYRVRRKYISRLLQ 142
Query: 1452 LPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMS 1273
++D + LS LN + A ++++ +I ++ ++F+ WK++
Sbjct: 143 KDAQYFDTV--STGYLSTVLNDNLERFREAFNEKIAFIICFSTDFVIGTTLAFYTDWKLA 200
Query: 1272 LQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVIL 1093
+F + +G+ N + + + + + + A +AL + +TV +LN + + +
Sbjct: 201 SYGSIFALGIAFSGFINSASMMGSTVKQNTHYANAGAIAFQALSSFKTVISLNGQAQELE 260
Query: 1092 LVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTY--L 919
+ L+ +RA T+ +FF A++ G L + +++ T
Sbjct: 261 RYSKELKAGEKYGARRAFFLATSRSVT---HFFCNALN---GIILYVGADLIYNKTMDQA 314
Query: 918 VLMTLS----MTASYAGSAVAYLPDHRKAIHAAGLIFH-LFTYPAIMPYDSSQGKRNIKN 754
V++TL +A G A ++ AI +A IF L + I+ + +R+ +
Sbjct: 315 VIVTLFHYMLFSAFSLGEAFPHISYLSNAISSASPIFAVLISKDDIIENHQNDTERDSER 374
Query: 753 --GEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAV 580
G+I+ NV F Y R + L GV+ + G +ALVG SGSGKSTI+ LL +Y+
Sbjct: 375 IEGDIQFDNVKFSYPTRPEAQALKGVTFNVKKGECVALVGASGSGKSTIVQLLLHYYNIE 434
Query: 579 DGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKV 400
G + ID+ ++ +NL LR ++ +VSQEPVLFN +I+EN FG + AS LEI +L+V
Sbjct: 435 SGNILIDDVDLNKINLKKLRGNIGVVSQEPVLFNTTIEENIRFG-NPAASTLEIYDSLRV 493
Query: 399 ANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSE 220
ANA+ FV+ FP+G+ T+VGERG QLSGGQKQRIAIAR +++NPK+LLLDEATSALD+ SE
Sbjct: 494 ANAYDFVNSFPKGIKTVVGERGTQLSGGQKQRIAIARVLVKNPKILLLDEATSALDNQSE 553
Query: 219 KVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLV 40
VV+ A+ AS+ +T+V+AHRLST+ + D I V+ +GK GTH++L+ +Y LV
Sbjct: 554 HVVRIAMKEASKGRTTIVIAHRLSTIQHCDRIIVMSHGKTVASGTHDKLMENSIVYKDLV 613
Query: 39 QKQGIQVE 16
Q Q + E
Sbjct: 614 QAQSLNSE 621
>gi|7508147|pir||T25083 hypothetical protein T21E8.1 - Caenorhabditis
elegans
Length = 1114
Score = 1404 bits (3635), Expect = 0.0
Identities = 717/1137 (63%), Positives = 871/1137 (76%), Gaps = 5/1137 (0%)
Frame = -1
Query: 3759 SNVCKFIKVIVGSTNNFLKKTFGFQIKCTTRYEKLLFFLGVVFSILTGMCQPFESYTLGE 3580
S +C FI+V+ KC++ +EK LF LGV+FS++TG CQPF SYT GE
Sbjct: 22 SQICSFIRVV---------------FKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGE 66
Query: 3579 TSQVLVKVTNAINNKTIDPVDLAHAYKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKF 3400
SQVLV +TNAINNKTIDP DL AY+ +E MN+VV FFL G AYF F LQ +IMK+
Sbjct: 67 VSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKY 126
Query: 3399 VGDNTAYNVRRQYISRLLRKDISYFDGMSTGHLSIVLNDNMERFREVFNEKIALIIALLT 3220
VGDNT Y VR+QYISRLL+KD YFD +STGHLS VLNDN+ERFREVFNEKIALIIA +T
Sbjct: 127 VGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVT 186
Query: 3219 DFVIGTILAFYTDWRLACYGTVFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQAL 3040
DF +GT LAFYTDWRLA YG FS GI SG ++S G MK KQN H +NAGSIAFQ L
Sbjct: 187 DFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTL 246
Query: 3039 GCYKTVSSLNGQQQEVERYTEELKNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGA 2860
G YKTV SLNGQ+ E+ERYTEELK GEKY + RA ++S+SR YFF N+LN V+LY GA
Sbjct: 247 GAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGA 306
Query: 2859 NMIYEGTIEPGVVVRILYYILFGSYCLGEAILHISRLASAIPLTVPIADILLDSDATADE 2680
MIY GT+E VVVR D +++ D T
Sbjct: 307 TMIYSGTLETAVVVR--------------------------------DDNVIEKDET--- 331
Query: 2679 FFSEEIKDTFQGIISFKNVLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQ 2500
+++ G ISFKNV FSYPTRPD VLK ISF+VQ GECIALVGASGSGKSTV+Q
Sbjct: 332 --DYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQ 389
Query: 2499 LLLHYYNIDSGRISIDGNDIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQ 2320
LLLHYYNIDSG I IDG D+ ++NIK+LR+ +GVV QEPVLFNT+IEENIRFG P+ +
Sbjct: 390 LLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLP 449
Query: 2319 EIIDALKNANAFDFVCNFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEAT 2140
EI AL+ ANA+DFVC+FP GIKTIVGERG QLSGGQKQRIAIARTLVRNP+ILLLDEAT
Sbjct: 450 EIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEAT 509
Query: 2139 SALDNESEFIVQEALQKASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAM 1960
SALDNESE +VQ+AL+ AS GRTTIVVAHRLSTIRNA+KIIVM+KGEIVEVG+H +LIA
Sbjct: 510 SALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAK 569
Query: 1959 NGVYNNLVQTQLMSTNYEKMNENEERVTRQSSHSDFPSNEISHQKIDQED-----DYVKK 1795
GVYN+LVQ QL+ + ++ E RQ S P + + Q+ D D +++
Sbjct: 570 RGVYNDLVQAQLLES-HDDHEELPPLAARQLSQELSPLHSYAIQRSTSNDAGVHDDDMER 628
Query: 1794 LIAEIKEEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFD 1615
++ E+ +EGAKKSN+ EI+K CR +YC LFIAV GSAIQG+ YP+ +QL++++YE +A
Sbjct: 629 ILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMI 688
Query: 1614 KDEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFY 1435
++ML SH WALS +FLA RP+ ++ QYY+FGK +E+LS +LR SF H++SLPCAFY
Sbjct: 689 GEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFY 748
Query: 1434 DDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMF 1255
DDP H+ATRLSNRLN DSSNV AAVDDRLG VIMT+VAI +A+ + Y WKM+L+VLMF
Sbjct: 749 DDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMF 808
Query: 1254 CPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHL 1075
PLLYLA YC + + A++ED+IAFE SNR AIEALENVRTVRALN+E++++ L++ HL
Sbjct: 809 FPLLYLAEYCYEAATETAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHL 868
Query: 1074 QKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMT 895
QKI SYFKRA+IQG ANG + SC+ F+Y+VSFKFGT+L LR+E+ PMDTYLVLMTLSMT
Sbjct: 869 QKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMT 928
Query: 894 ASYAGSAVAYLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYA 715
A+ AGSA AYLPD++KA+HAAGLIFHLFTYPA MP+ SS GK+NI+ GEI +NV F Y
Sbjct: 929 ANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGENVQFHYD 988
Query: 714 QRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVN 535
QR D+MIL+GV+LK+ G+TLALVGPSG GKSTIISLLERFYHAVDGEVKID ENV D+N
Sbjct: 989 QRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDIN 1048
Query: 534 LHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQ 364
L+HLR +++LVSQEP LFNCSI+EN L+G++ + QLE+++AL+ ANAF+FV QFPQ
Sbjct: 1049 LNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQ 1105
Score = 281 bits (719), Expect = 9e-74
Identities = 195/611 (31%), Positives = 304/611 (48%), Gaps = 33/611 (5%)
Frame = -1
Query: 1764 KKSNICEIIKY---CRS--EYCILFIAVLGSAIQGIYYPLSS-------QLMI------- 1642
K S IC I+ C S E + + VL S + G P S Q+++
Sbjct: 20 KPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAIN 79
Query: 1641 ----------KSYEAYAFDKDEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLS 1492
K+YE Y ++++ HF+ + IF Q+ + +
Sbjct: 80 NKTIDPADLEKAYEEYERGMNQVVF--HFFLCGCAYF-----IFASLQHAIMKYVGDNTT 132
Query: 1491 IKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILL 1312
++R L+ ++D + LS LN + ++++ +I + L
Sbjct: 133 YRVRKQYISRLLKKDAQYFDSV--STGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTL 190
Query: 1311 AVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVR 1132
++F+ W+++ + F + +G+ N V + + + + + A + L +
Sbjct: 191 GTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYK 250
Query: 1131 TVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVL 952
TV +LN + I T L+ +RA++ + G YFF +++
Sbjct: 251 TVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVT---YFFCNSLN--------- 298
Query: 951 REEILPMDTYLVLMTLSMTASYAGS---AVAYLPDHRKAIHAAGLIFHLFTYPAIMPYDS 781
V++ + T Y+G+ AV D+ ++ D
Sbjct: 299 ----------TVVLYVGATMIYSGTLETAVVVRDDN------------------VIEKDE 330
Query: 780 SQGKRNIK-NGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISL 604
+ ++ NG I KNV F Y R D +L G+S + G +ALVG SGSGKST++ L
Sbjct: 331 TDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQL 390
Query: 603 LERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQL 424
L +Y+ G + ID ++ D+N+ LR + +VSQEPVLFN +I+EN FG + N S
Sbjct: 391 LLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFG-NPNVSLP 449
Query: 423 EIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEAT 244
EI AL+ ANA+ FV FP+G+ T+VGERG QLSGGQKQRIAIAR ++RNPK+LLLDEAT
Sbjct: 450 EIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEAT 509
Query: 243 SALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRK 64
SALD++SE+VVQ AL+ AS+ +T+VVAHRLST+ NA I V++ G++ E G H+EL+ K
Sbjct: 510 SALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAK 569
Query: 63 RSIYWRLVQKQ 31
R +Y LVQ Q
Sbjct: 570 RGVYNDLVQAQ 580
>gi|39594943|emb|CAE70811.1| Hypothetical protein CBG17574
[Caenorhabditis briggsae]
Length = 1628
Score = 1079 bits (2791), Expect = 0.0
Identities = 543/1010 (53%), Positives = 740/1010 (72%), Gaps = 3/1010 (0%)
Frame = -1
Query: 3105 MKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNRAFVFS 2926
M ++ Q+ H +NAG IA+QAL C+KTV SLNGQ E++ Y+ ELK GEK+ ++RA +F+
Sbjct: 2 MGASKAQSYHYANAGGIAYQALSCFKTVISLNGQSYELKSYSSELKLGEKHGIHRALLFA 61
Query: 2925 LSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEAILHISRLA 2746
SR+ FF +ALN +LY GA +IY T++ +V + +Y++ +Y L E + HIS L
Sbjct: 62 TSRAVTNFFCSALNGTLLYIGAGLIYNKTMDQASIVTLFHYMMLSAYSLAEVLPHISNLL 121
Query: 2745 SAIPLTVPIADILLDSDATADEFFSEEIKDT---FQGIISFKNVLFSYPTRPDVPVLKEI 2575
+AI I +IL +D D +E++ D G+I FK+V FSYPTRP+ VLK I
Sbjct: 122 NAISSASSIFEILTSND---DNIENEDVPDDQKPINGVIQFKDVRFSYPTRPNAKVLKGI 178
Query: 2574 SFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAMGVV 2395
S V+ GEC+ALVGASGSGKST++QLLL +YN DSG ISIDG ++ NI++K+LR+ +GVV
Sbjct: 179 SLEVKRGECVALVGASGSGKSTLVQLLLRHYNKDSGSISIDGVELENISLKKLRRNIGVV 238
Query: 2394 FQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGERGAQLSG 2215
QEP+LF+T+IE+NIRFG P+ ++ EI DALK ANA++FV +FP+GI+TIVGE GAQLSG
Sbjct: 239 SQEPILFDTTIEQNIRFGNPECSKFEIFDALKKANAYEFVASFPNGIETIVGEGGAQLSG 298
Query: 2214 GQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHRLSTIR 2035
GQKQRIAIAR LV+NP+ILLLDEATSALDNESE +Q+AL+KAS GRTTI++AHRLSTI
Sbjct: 299 GQKQRIAIARVLVKNPKILLLDEATSALDNESEREIQKALRKASEGRTTIIIAHRLSTIN 358
Query: 2034 NANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNENEERVTRQSSHSD 1855
N +KIIVM +G+I+E G HK LI G YNNL+ +Q+ ++EE+ T Q D
Sbjct: 359 NCDKIIVMSQGQIIESGAHKHLIQKAGAYNNLINSQIF--------DSEEKQTSQKDPLD 410
Query: 1854 FPSNEISHQKIDQEDDYVKKLIAEIKEEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQG 1675
+ + + + + + + EE S EII CR +Y L A++GS +QG
Sbjct: 411 INKIKENSNSLRKSSKGSQASLTDTPEEKEVSSGFWEIINECRPQYFWLLTAIIGSFMQG 470
Query: 1674 IYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKL 1495
+ PL +QL++++Y+AY+ + +++L HFWA L RPI + +Y +G+ AEKL
Sbjct: 471 LSPPLLAQLIVRTYKAYSMEGEDILIYGHFWASMFFALGLIRPITAYTTHYCYGRVAEKL 530
Query: 1494 SIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAIL 1315
S +LR SF H++SLPCAFYD+ ++ TRL+NRLN D+SNV AVD RLG++ TLV+ L
Sbjct: 531 STRLRIKSFHHMLSLPCAFYDESKNSPTRLANRLNTDASNVKGAVDSRLGTIFTTLVSFL 590
Query: 1314 LAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENV 1135
+++ ++ +YSWK+++Q+++F P+LY C DN Q+V++DS EKSN+ A+E L N+
Sbjct: 591 VSISVASYYSWKLTIQIILFFPILYFGKRCYDNATVQSVKQDSALIEKSNKIAVEVLNNI 650
Query: 1134 RTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLV 955
+TVR+LNM ++V+ ++ L+ +R Y +A+ G ANGF+ C++F YA SFKFGT L+
Sbjct: 651 KTVRSLNMGDKVMSMIIGELEVLRKKYRWKAITLGLANGFSVICHYFFYAASFKFGTHLI 710
Query: 954 LREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQ 775
L+ EILPM+ Y+ +TLS T++ G+ + YLP++RKA+HAAGLIF+L PA MPYDS +
Sbjct: 711 LQREILPMNMYVSFITLSYTSNMVGNVMLYLPEYRKAVHAAGLIFNLLKTPATMPYDSKE 770
Query: 774 GKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLER 595
G IKNG ++ N+SF Y QR D M+L V+L L G+TLALVGPSGSGKS+ ISL+ER
Sbjct: 771 GSMEIKNGVVKGSNISFHYHQRLDHMVLKNVNLSLKPGKTLALVGPSGSGKSSFISLIER 830
Query: 594 FYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEID 415
FY G VKID E+V D+N+HHLR ++ LV+QEPVLFNCSI++N L+G+ +++I+
Sbjct: 831 FYQVDTGCVKIDNEDVEDINIHHLRSNLGLVAQEPVLFNCSIRQNLLYGLEELVEEIKIE 890
Query: 414 QALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSAL 235
+AL+ ANA F+ +FP+GL+T+VGE GAQLSGGQKQRIAIARAILRNPK+LLLDEATSAL
Sbjct: 891 KALRTANALDFIQKFPEGLNTIVGEHGAQLSGGQKQRIAIARAILRNPKILLLDEATSAL 950
Query: 234 DSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGT 85
DSDSEK+VQNALDTA ERLSTVVVAHRLST+VNADSIAV +NG+V EQG+
Sbjct: 951 DSDSEKLVQNALDTAIERLSTVVVAHRLSTIVNADSIAVFENGQVVEQGS 1000
Score = 665 bits (1717), Expect = 0.0
Identities = 340/588 (57%), Positives = 439/588 (73%), Gaps = 5/588 (0%)
Frame = -1
Query: 2394 FQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGERGAQLSG 2215
F++ + S ENI FG P+AT EI +AL+ ANA+DFV +FP GIK++VGERGAQLSG
Sbjct: 1037 FRKAFYNSASRGENILFGNPNATVSEIYEALRKANAYDFVNSFPKGIKSVVGERGAQLSG 1096
Query: 2214 GQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHRLSTIR 2035
GQKQRIAIARTLVRNP+ILLL EATSALDNESE +VQ AL+KAS GRTTIV+AHRLSTIR
Sbjct: 1097 GQKQRIAIARTLVRNPKILLL-EATSALDNESEHVVQRALEKASEGRTTIVIAHRLSTIR 1155
Query: 2034 NANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNENEERVTRQSSHSD 1855
NA+KIIVM+KGEIV+VG N + E + SS ++
Sbjct: 1156 NASKIIVMDKGEIVKVG-----------------------NVLDHSSQELSARQDSSRTE 1192
Query: 1854 FPSNEISHQKIDQEDDYVKKLIAEIKEEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQG 1675
F + +DD +K+L+ E+ EEGA+KSN+ EIIK C+ +YC+ A+ GSA+QG
Sbjct: 1193 FSETN------EAQDDEIKRLMNELTEEGAQKSNLREIIKMCKPDYCLFLTALAGSALQG 1246
Query: 1674 IYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKL 1495
+ Y +S +L +++YEA+A + ++++ HFWA +IL LA RPI + QYY+ GK +E+L
Sbjct: 1247 LSYQISVKLTVRAYEAFAMNGEDIMIYGHFWAFAILLLALFRPITLRCQYYYLGKVSERL 1306
Query: 1494 SIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAIL 1315
S +LR SFKHLMSLPC+FYDDP H+A RLSNRLN D+SNV A+VDDRLGSV MT VAI
Sbjct: 1307 STRLRMKSFKHLMSLPCSFYDDPKHSAIRLSNRLNTDASNVKASVDDRLGSVFMTFVAIS 1366
Query: 1314 LAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENV 1135
+A+ S YSWKM++QVL+ CP+LYLA YC + +D A+E+D++AFE SNRAAIEA+E++
Sbjct: 1367 IAISTSTVYSWKMTIQVLLLCPILYLAEYCYERAIDGAIEKDTLAFENSNRAAIEAIEHI 1426
Query: 1134 RTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLV 955
RTVRALNME+R++ +V HLQK NS FKRAVIQG ANGF C C+F+IY++SFKFGTWL
Sbjct: 1427 RTVRALNMEDRIMDMVADHLQKSHNSCFKRAVIQGAANGFFCCCFFYIYSISFKFGTWLA 1486
Query: 954 LREEILPMDTYLVLMTLSMTASY-----AGSAVAYLPDHRKAIHAAGLIFHLFTYPAIMP 790
+ +EI+PM+TY+V MTL++T++Y AGSAVAYLPD++KA HAAGLIFHLFTYP M
Sbjct: 1487 MHKEIMPMETYMVSMTLTLTSTYDLWLMAGSAVAYLPDYKKAAHAAGLIFHLFTYPETMA 1546
Query: 789 YDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLAL 646
Y S G +NIK G++ +N+ F Y QR DK ILDGV+L++ G+TLAL
Sbjct: 1547 YGSKDGTKNIKLGKVVGENLKFHYEQRPDKTILDGVNLRVEPGKTLAL 1594
Score = 253 bits (646), Expect = 3e-65
Identities = 150/396 (37%), Positives = 231/396 (57%), Gaps = 5/396 (1%)
Frame = -1
Query: 1203 AVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTA 1024
A + S + + A +AL +TV +LN ++ + +S L+ RA++ T+
Sbjct: 4 ASKAQSYHYANAGGIAYQALSCFKTVISLNGQSYELKSYSSELKLGEKHGIHRALLFATS 63
Query: 1023 NG---FACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDH 853
F CS + G L+ + + + + ++A + ++ +
Sbjct: 64 RAVTNFFCSA---LNGTLLYIGAGLIYNKTMDQASIVTLFHYMMLSAYSLAEVLPHISNL 120
Query: 852 RKAIHAAGLIFHLFTY--PAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVS 679
AI +A IF + T I D ++ I NG I+ K+V F Y R + +L G+S
Sbjct: 121 LNAISSASSIFEILTSNDDNIENEDVPDDQKPI-NGVIQFKDVRFSYPTRPNAKVLKGIS 179
Query: 678 LKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVS 499
L++ G +ALVG SGSGKST++ LL R Y+ G + ID + +++L LR ++ +VS
Sbjct: 180 LEVKRGECVALVGASGSGKSTLVQLLLRHYNKDSGSISIDGVELENISLKKLRRNIGVVS 239
Query: 498 QEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSG 319
QEP+LF+ +I++N FG + S+ EI ALK ANA+ FV+ FP G++T+VGE GAQLSG
Sbjct: 240 QEPILFDTTIEQNIRFG-NPECSKFEIFDALKKANAYEFVASFPNGIETIVGEGGAQLSG 298
Query: 318 GQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVV 139
GQKQRIAIAR +++NPK+LLLDEATSALD++SE+ +Q AL ASE +T+++AHRLST+
Sbjct: 299 GQKQRIAIARVLVKNPKILLLDEATSALDNESEREIQKALRKASEGRTTIIIAHRLSTIN 358
Query: 138 NADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
N D I V+ G++ E G H+ L++K Y L+ Q
Sbjct: 359 NCDKIIVMSQGQIIESGAHKHLIQKAGAYNNLINSQ 394
Score = 145 bits (366), Expect = 7e-33
Identities = 77/126 (61%), Positives = 101/126 (80%)
Frame = -1
Query: 465 ENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARA 286
EN LFG + NA+ EI +AL+ ANA+ FV+ FP+G+ ++VGERGAQLSGGQKQRIAIAR
Sbjct: 1049 ENILFG-NPNATVSEIYEALRKANAYDFVNSFPKGIKSVVGERGAQLSGGQKQRIAIART 1107
Query: 285 ILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNG 106
++RNPK+LLL EATSALD++SE VVQ AL+ ASE +T+V+AHRLST+ NA I V+ G
Sbjct: 1108 LVRNPKILLL-EATSALDNESEHVVQRALEKASEGRTTIVIAHRLSTIRNASKIIVMDKG 1166
Query: 105 KVAEQG 88
++ + G
Sbjct: 1167 EIVKVG 1172
Score = 74.7 bits (182), Expect = 2e-11
Identities = 37/65 (56%), Positives = 44/65 (66%)
Frame = -1
Query: 3087 QNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNRAFVFSLSRSAD 2908
+N + GSIAFQALG +KTV SL GQQQEV RY+EELK GE+Y +AF S SR +
Sbjct: 991 ENGQVVEQGSIAFQALGAFKTVCSLTGQQQEVHRYSEELKAGERYGFRKAFYNSASRGEN 1050
Query: 2907 YFFTN 2893
F N
Sbjct: 1051 ILFGN 1055
>gi|39585393|emb|CAE61715.1| Hypothetical protein CBG05664
[Caenorhabditis briggsae]
Length = 1294
Score = 890 bits (2301), Expect = 0.0
Identities = 496/1241 (39%), Positives = 752/1241 (59%), Gaps = 19/1241 (1%)
Frame = -1
Query: 3690 FQI-KCTTRYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDL 3514
FQ+ + T+ ++++ +G++ S TG+ P S +G SQ V++ + N T DP +
Sbjct: 33 FQLFRYTSTMDRIMLIVGILVSCATGLGLPLMSIIMGNVSQNFVEIGTILMNST-DPAVI 91
Query: 3513 AHAYKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDI 3334
A F D+ + L + +G F G +Q S + +N + RR++ ++R +I
Sbjct: 92 KKAKDDFSHDVIQNCLQYVYLGAGIFAAGMIQASCFLIICENLSNRFRREFFYSVMRHEI 151
Query: 3333 SYFDGMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTV 3154
+++D ++G LS L DN+ER RE +K+ L ++ F+ G +AF DW L
Sbjct: 152 AWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFLGGFAVAFSYDWLLTLIMMS 211
Query: 3153 FSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEE 2974
S +++ GL + K+ + + AG IA + L +TV + NGQ+ E +RY E
Sbjct: 212 LSPFMMICGLFLAKLLATAATKEAKQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEEA 271
Query: 2973 LKNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILF 2794
L +G K + ++F+ ++ + A + + G N +Y G ++ G V+ + + ++
Sbjct: 272 LSHGRKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYNGRLDSGTVLTVFFSVMM 331
Query: 2793 GSYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLF 2617
GS LG+A + + +A+ + +++ D D + ++ + + G I +N+ F
Sbjct: 332 GSMALGQAGQQFATIGTALGAAASLYEVI-DRTPEIDAYSTKGVTPEKISGRIKIQNIEF 390
Query: 2616 SYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIY 2437
+YPTRPDV +LK++S Q G+ IALVG+SG GKST+IQLL +YN D+G+I ID I
Sbjct: 391 TYPTRPDVQILKDVSLEAQPGQTIALVGSSGCGKSTIIQLLQRFYNPDAGKIYIDDIAIE 450
Query: 2436 NINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDG 2257
+ NIK LRQ +GVV QEP LFNTSIE+NIR+G+ D I ALK ANA DF+ FP+G
Sbjct: 451 DFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRADVDSDAINRALKEANALDFIKTFPEG 510
Query: 2256 IKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIG 2077
+ T+VG+RG Q+SGGQKQRIAIAR LVRNP+ILLLDEATSALD ESE +VQ AL AS G
Sbjct: 511 LNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESVVQAALDNASRG 570
Query: 2076 RTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEK-- 1903
RTTIV+AHRLST+RNA+KIIVM+ G+++E+G H LI G+Y+ LV Q+ + EK
Sbjct: 571 RTTIVIAHRLSTVRNADKIIVMKAGKVMEIGTHDTLIEQKGLYHELVHAQVFADVDEKPR 630
Query: 1902 -MNENEERVTRQSSHSDFPSNEISHQKIDQE----------DDYVKKLIAEIKEEGAKKS 1756
E E R++RQ+S + + +++ + +K+L E++EEGA K+
Sbjct: 631 AKKEAERRLSRQTSARKGSLIKTQESQAEEKSGPPPAPEPAEKEIKRLRKELEEEGAVKA 690
Query: 1755 NICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAF-DKDEMLSKSHFWA 1579
N+ +I+KY R E+ +F A++ + IQG P S + ++ D+++M HFWA
Sbjct: 691 NLFKILKYARPEWMYIFFAIIAALIQGAVMPAFSLFFSQIINVFSNPDREQMKKDGHFWA 750
Query: 1578 LSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSN 1399
L L LA + + FQ FFG AE L++++RS +++++ ++D P H+ R++
Sbjct: 751 LMFLVLAAIQGTSMLFQCAFFGVAAEGLTMRVRSKVYRNVLRQDATYFDMPKHSPGRITT 810
Query: 1398 RLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCND 1219
RL D+ N+ +A+D RLGSV + ++ + ++F+Y W+M+L V+ P + +
Sbjct: 811 RLATDAPNIKSAIDYRLGSVFNAIASVGGGLGIAFYYGWQMALLVMAIFPFMAVGQALVI 870
Query: 1218 NFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAV 1039
+ + D+ E S + A+EA+EN+RTV+AL ++ ++ + SHL + +A+
Sbjct: 871 KYHGGSATADAKEMENSGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDSPHSGNVSKAI 930
Query: 1038 IQGTANGFACSCYFFIYAVSFKFGTWLVLREEIL--PMDTYLVLMTLSMTASYAGSAVAY 865
I+G GFA S FF YA +F+FG +L+ + +L P VL +S + G A +Y
Sbjct: 931 IRGLTYGFANSIQFFTYAAAFRFGLFLIFNQNVLMSPEHVLKVLFAISFSFGTIGFAASY 990
Query: 864 LPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDG 685
P++ KA AAGLIF++ + ++ G +GE++L V F Y +R IL G
Sbjct: 991 FPEYIKATFAAGLIFNMLEEEPRIDGMTNAGTLPALSGEVKLNKVFFRYPERPAVPILQG 1050
Query: 684 VSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSL 505
+ + + G+TLALVGPSG GKST+ISLLER Y ++G V ID N+ +N HLR+ ++L
Sbjct: 1051 LDVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTIDNNNLRQMNPKHLRKHIAL 1110
Query: 504 VSQEPVLFNCSIKENFLFGISHNA-SQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQ 328
VSQEP+LF+ SI+EN ++G+ ++ I A + AN F+S+ P G T VGE+G Q
Sbjct: 1111 VSQEPILFDTSIRENIIYGLQPGEYTEEAIAVACEKANIHKFISELPDGYQTRVGEKGTQ 1170
Query: 327 LSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLS 148
LSGGQKQRIAIARA++RNPK+LLLDEATSALD++SEK VQ ALD A++ + +VVAHRLS
Sbjct: 1171 LSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQIALDAAAKDRTCIVVAHRLS 1230
Query: 147 TVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGI 25
T+VNA I V+KNGKV EQGTH EL+ KR Y+ L QKQ I
Sbjct: 1231 TIVNAGCIMVVKNGKVVEQGTHLELMAKRGAYFALTQKQSI 1271
>gi|17558664|ref|NP_507487.1| P-GlycoProtein related (pgp-9)
[Caenorhabditis elegans]
gi|7497530|pir||T19982 hypothetical protein C47A10.1 - Caenorhabditis
elegans
gi|3875004|emb|CAB03973.1| Hypothetical protein C47A10.1
[Caenorhabditis elegans]
gi|3879215|emb|CAB07855.1| Hypothetical protein C47A10.1
[Caenorhabditis elegans]
Length = 1294
Score = 885 bits (2287), Expect = 0.0
Identities = 490/1239 (39%), Positives = 755/1239 (60%), Gaps = 19/1239 (1%)
Frame = -1
Query: 3690 FQI-KCTTRYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDL 3514
FQ+ + T+ ++L+ +G++ S TG+ P S +G SQ V + + +
Sbjct: 32 FQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEK 91
Query: 3513 AHAYKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDI 3334
A A F ++ + L + +G F GFLQ S + + + RRQ+ ++R++I
Sbjct: 92 AAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEI 151
Query: 3333 SYFDGMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTV 3154
+++D ++G LS L DN+ER RE +K+ L ++ F+ G +AF DW L
Sbjct: 152 AWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMS 211
Query: 3153 FSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEE 2974
S +++ GL + K+ + + AG IA + L +TV + NGQ+ E +RY +
Sbjct: 212 LSPFMMICGLFLAKLLATAATKEAKQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDA 271
Query: 2973 LKNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILF 2794
L++G+K + ++F+ ++ + A + + G N +Y G +E G V+ + + ++
Sbjct: 272 LEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMM 331
Query: 2793 GSYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSE-EIKDTFQGIISFKNVLF 2617
GS LG+A + + +A+ + +++ D D + +E + G IS V F
Sbjct: 332 GSMALGQAGQQFATIGTALGAAASLYEVI-DRIPEIDAYSTEGQTPSKISGRISVNKVEF 390
Query: 2616 SYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIY 2437
+YPTR DV +LK +S + Q G+ +ALVG+SG GKST+IQLL +YN D+G+I ID I
Sbjct: 391 TYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIE 450
Query: 2436 NINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDG 2257
+ NIK LRQ +GVV QEP LFNTSIE+NIR+G+ D ++++I ALK ANA DF+ FP+G
Sbjct: 451 DFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEG 510
Query: 2256 IKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIG 2077
+ T+VG+RG Q+SGGQKQRIAIAR LVRNP+ILLLDEATSALD ESE IVQ AL+ AS G
Sbjct: 511 LNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRG 570
Query: 2076 RTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMS--TNYEK 1903
RTTIV+AHRLST+RNA+KIIVM+ G+++EVG H+ LI G+Y+ LV Q+ + + K
Sbjct: 571 RTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVDDKPK 630
Query: 1902 MNENEERVTRQSSHSDFPSN-EISHQKIDQE----------DDYVKKLIAEIKEEGAKKS 1756
E E R++RQ+S N + ++D++ + +K+L E++EEGA K+
Sbjct: 631 KKEAERRMSRQTSQRKGSVNFKTQESQVDEKPGAPPAPEAAEKEIKRLKKELEEEGAVKA 690
Query: 1755 NICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAF-DKDEMLSKSHFWA 1579
N+ +I++Y R E+ +F A++ + IQG P S + ++ D+D+M HFWA
Sbjct: 691 NLFKILRYARPEWIYIFFAIIAALIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHFWA 750
Query: 1578 LSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSN 1399
L L LA + + FQ FG AE+L++++RS +++++ ++D P H+ R++
Sbjct: 751 LMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITT 810
Query: 1398 RLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCND 1219
RL D+ N+ +A+D RLGS+ + ++ + ++F+Y W+M+ V+ P + +
Sbjct: 811 RLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMM 870
Query: 1218 NFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAV 1039
+ + D+ E + + A+EA+EN+RTV+AL ++ ++ + SHL +A+
Sbjct: 871 KYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAI 930
Query: 1038 IQGTANGFACSCYFFIYAVSFKFGTWLVLREEIL--PMDTYLVLMTLSMTASYAGSAVAY 865
I+G GFA S FF YA +F+FG +L+ + +L P + VL +S + G A +Y
Sbjct: 931 IRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASY 990
Query: 864 LPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDG 685
P++ KA AAGLIF++ + +S G +GE++L V F Y +R IL G
Sbjct: 991 FPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVFFRYPERPAVPILQG 1050
Query: 684 VSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSL 505
+++ + G+TLALVGPSG GKST+ISLLER Y ++G V +D ++ +N HLR+ ++L
Sbjct: 1051 LNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIAL 1110
Query: 504 VSQEPVLFNCSIKENFLFGISHNA-SQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQ 328
VSQEP+LF+ SI+EN ++G+ + +I+ A AN F+ + P G +T VGE+G Q
Sbjct: 1111 VSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQ 1170
Query: 327 LSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLS 148
LSGGQKQRIAIARA++RNPK+LLLDEATSALD++SEK VQ ALD A++ + +VVAHRLS
Sbjct: 1171 LSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLS 1230
Query: 147 TVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
T+VNA I V+KNG+V EQGTH EL+ KR Y+ L QKQ
Sbjct: 1231 TIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQ 1269
>gi|39587899|emb|CAE67917.1| Hypothetical protein CBG13514
[Caenorhabditis briggsae]
Length = 1319
Score = 833 bits (2151), Expect = 0.0
Identities = 474/1250 (37%), Positives = 726/1250 (57%), Gaps = 35/1250 (2%)
Frame = -1
Query: 3675 TTRYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAIN--NKTIDPVDLAHAY 3502
TT EK++ +G + +I+TG P S G+ SQ + IN N TI P +
Sbjct: 69 TTMTEKIMLLVGTIVAIITGAGLPLMSILQGQVSQAFINEQIVINTGNHTIPPNGRNYTD 128
Query: 3501 KLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFD 3322
F D+ +VV L+ + + G + + +V + +RR+++ +LR+DIS+FD
Sbjct: 129 SDFNHDVMQVVWLYAGMTIGMWAAGQITVTCYLYVAEQMNNRLRREFVKAILRQDISWFD 188
Query: 3321 GMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFG 3142
+G L+ L DN+ER +E +KI + ++ F+ G I+AF W+L +
Sbjct: 189 TNHSGTLATKLFDNLERVKEGTGDKIGMAFQYMSQFITGFIVAFTHSWKLTLVMLAVTPI 248
Query: 3141 IVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNG 2962
L G L + ++ + AG + + + +TV SLNG + E+ERY+ ++
Sbjct: 249 QALCGFLIAKSMSTFAIRETVRYAKAGKVVEETISSIRTVVSLNGLRHELERYSTAVEEA 308
Query: 2961 EKYALNRAFVFSLS---RSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFG 2791
+K + + +S A FF+ AL F Y G +++G++ PG ++ ++ G
Sbjct: 309 KKSGVLKGLFLGISFGAMQATNFFSFALAF---YIGVGWVHDGSLAPGDMLTTFSSVMMG 365
Query: 2790 SYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIKDT-FQGIISFKNVLFS 2614
S LG A ++ L +A I ++L D D S KD +G I+ +NV F+
Sbjct: 366 SMALGLAGPQLAVLGTAQGAASSIYEVL-DRKPVIDSSSSAGRKDMKIKGDITVENVHFT 424
Query: 2613 YPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYN 2434
YP+R DVP+L+ ++ V G+ +ALVG+SG GKST+I LLL YY++ G I+IDG D+ +
Sbjct: 425 YPSRQDVPILRGMNLRVNAGQTVALVGSSGCGKSTIISLLLRYYDVLKGNITIDGVDVRD 484
Query: 2433 INIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGI 2254
IN++ LR + VV QEP LFN +IEENIR G+ D T +E+I A K ANA F+ P G
Sbjct: 485 INLEFLRTNVAVVSQEPALFNCTIEENIRLGREDITREEMIAACKMANAEKFIKTLPAGY 544
Query: 2253 KTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGR 2074
T+VG+RG QLSGGQKQRIAIAR LVRNP+ILLLDEATSALD ESE IVQ+AL KA+ GR
Sbjct: 545 NTLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAESEGIVQQALDKAAKGR 604
Query: 2073 TTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMS-------- 1918
TTI++AHRLSTIRNA+ II + G++VEVGDH+ L+A G+Y +LV Q +
Sbjct: 605 TTIIIAHRLSTIRNADLIISCKNGQVVEVGDHRTLMAQEGLYYDLVTAQTFTDAVDASAG 664
Query: 1917 ------TNYEKMNENEERVTRQSSHSDFPSNEISHQK---------IDQED-----DYVK 1798
+ + E + RQ+S D N + I++++ D +
Sbjct: 665 GKFSRENSIARQTSEHEGIFRQASELDDVLNRVRSSTMGSITNGPVIEEKEQRIGKDALT 724
Query: 1797 KLIAEIKEEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAF 1618
+L E++E A+++N+ EI+ + + + I + + + G YP S ++
Sbjct: 725 RLKEELEENNAQRTNLFEILYHAKPHALSVAIGITAAIVGGFIYPTYSVFFTSFINVFSG 784
Query: 1617 DKDEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAF 1438
+ D++LS+ HFWAL L LA + I F +F G +E L++ LR+ F++++S F
Sbjct: 785 NPDDILSQGHFWALMFLVLAAAQGICSFLMTFFMGIASESLTMDLRNKLFRNVLSQHIGF 844
Query: 1437 YDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLM 1258
+D P + + ++ RL D N+ A+D R +VI TLV+++ + ++F+Y W+M+L ++
Sbjct: 845 FDSPQNASGKICTRLATDVPNLRTAIDFRFSTVITTLVSMIAGIGLAFYYGWQMALLIVA 904
Query: 1257 FCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSH 1078
P++ Y + + F S + AIEA+ENVRTV+AL E+ S
Sbjct: 905 ILPIVGFGQYLRGRRFTGNNVKSASEFADSGKIAIEAIENVRTVQALAREDTFYYKFCSK 964
Query: 1077 LQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSM 898
L K A IQG + G ACS + + +++ G L+L + PM V+ +++
Sbjct: 965 LDVPHKEAIKEAFIQGLSYGCACSVLYLLNTCAYRMGLALILHRTMTPMRVLRVMYAITI 1024
Query: 897 TASYAGSAVAYLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEY 718
+ S G A +Y P++ KA A G+IF + + + + G++ +G++ KNV F Y
Sbjct: 1025 STSTLGFATSYFPEYAKATFAGGIIFGMLKQKSEIDSLTLSGEKKKLSGKVIFKNVRFAY 1084
Query: 717 AQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDV 538
+R IL G+S + G+TLALVGPSG GKST+++LLERFY + GEV ID + +
Sbjct: 1085 PERPQIEILKGLSFSVDPGQTLALVGPSGCGKSTVVALLERFYDTLAGEVFIDGSEIKTL 1144
Query: 537 NLHHLRESVSLVSQEPVLFNCSIKENFLFGIS-HNASQLEIDQALKVANAFSFVSQFPQG 361
N + R +++VSQEP LF+CSI EN ++G+ + +++A K+AN +F+S+ P+G
Sbjct: 1145 NPENTRSQIAIVSQEPTLFDCSIAENIVYGLDPTTVTMSRVEEAAKLANIHNFISELPEG 1204
Query: 360 LDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASER 181
+T VG+RG QLSGGQKQRIAIARA++RNPK+LLLDEATSALD++SEK+VQ ALD A E
Sbjct: 1205 YETRVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEKIVQEALDRAREG 1264
Query: 180 LSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
+ +V+AHRL+T++NAD IAV+ NG + EQGTH L+ ++ Y++L QKQ
Sbjct: 1265 RTCIVIAHRLNTIMNADCIAVVNNGTIIEQGTHSVLMSQQGAYYKLTQKQ 1314
Score = 306 bits (783), Expect = 3e-81
Identities = 207/605 (34%), Positives = 307/605 (50%), Gaps = 8/605 (1%)
Frame = -1
Query: 3714 NFLKKTFGFQIKCTTRYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNK 3535
N ++T F+I + L +G+ +I+ G P +Y++ TS + N +
Sbjct: 733 NNAQRTNLFEILYHAKPHALSVAIGITAAIVGGFIYP--TYSVFFTSFI-----NVFSGN 785
Query: 3534 TIDPVDLAHAYKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYIS 3355
D + H + L+F ++ A FL M ++ ++R +
Sbjct: 786 PDDILSQGHFW----------ALMFLVLAAAQGICSFLMTFFMGIASESLTMDLRNKLFR 835
Query: 3354 RLLRKDISYFDGM--STGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTD 3181
+L + I +FD ++G + L ++ R + + + +I L + G LAFY
Sbjct: 836 NVLSQHIGFFDSPQNASGKICTRLATDVPNLRTAIDFRFSTVITTLVSMIAGIGLAFYYG 895
Query: 3180 WRLACYGT----VFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSL 3013
W++A + FG L G + NN K +++G IA +A+ +TV +L
Sbjct: 896 WQMALLIVAILPIVGFGQYLRGRRFTG----NNVKSASEFADSGKIAIEAIENVRTVQAL 951
Query: 3012 NGQQQEVERYTEELKNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIE 2833
+ ++ +L K A+ AF+ LS LN G +I T+
Sbjct: 952 AREDTFYYKFCSKLDVPHKEAIKEAFIQGLSYGCACSVLYLLNTCAYRMGLALILHRTMT 1011
Query: 2832 PGVVVRILYYILFGSYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIKDT 2653
P V+R++Y I + LG A + A A I +L + D K
Sbjct: 1012 PMRVLRVMYAITISTSTLGFATSYFPEYAKAT-FAGGIIFGMLKQKSEIDSLTLSGEKKK 1070
Query: 2652 FQGIISFKNVLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNID 2473
G + FKNV F+YP RP + +LK +SF+V G+ +ALVG SG GKSTV+ LL +Y+
Sbjct: 1071 LSGKVIFKNVRFAYPERPQIEILKGLSFSVDPGQTLALVGPSGCGKSTVVALLERFYDTL 1130
Query: 2472 SGRISIDGNDIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFG--KPDATEQEIIDALK 2299
+G + IDG++I +N + R + +V QEP LF+ SI ENI +G T + +A K
Sbjct: 1131 AGEVFIDGSEIKTLNPENTRSQIAIVSQEPTLFDCSIAENIVYGLDPTTVTMSRVEEAAK 1190
Query: 2298 NANAFDFVCNFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNES 2119
AN +F+ P+G +T VG+RG QLSGGQKQRIAIAR LVRNP+ILLLDEATSALD ES
Sbjct: 1191 LANIHNFISELPEGYETRVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTES 1250
Query: 2118 EFIVQEALQKASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNL 1939
E IVQEAL +A GRT IV+AHRL+TI NA+ I V+ G I+E G H L++ G Y L
Sbjct: 1251 EKIVQEALDRAREGRTCIVIAHRLNTIMNADCIAVVNNGTIIEQGTHSVLMSQQGAYYKL 1310
Query: 1938 VQTQL 1924
Q Q+
Sbjct: 1311 TQKQM 1315
>gi|17541710|ref|NP_502413.1| P-GlycoProtein related (pgp-1)
[Caenorhabditis elegans]
gi|29429182|sp|P34712|MDR1_CAEEL Multidrug resistance protein 1
(P-glycoprotein A)
gi|7505559|pir||T23476 hypothetical protein K08E7.9 - Caenorhabditis
elegans
gi|3878418|emb|CAB01232.1| Hypothetical protein K08E7.9
[Caenorhabditis elegans]
Length = 1321
Score = 823 bits (2127), Expect = 0.0
Identities = 477/1252 (38%), Positives = 725/1252 (57%), Gaps = 37/1252 (2%)
Frame = -1
Query: 3675 TTRYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNK--TIDPVDLAHAY 3502
TT EKLL F+G + +++TG P S G+ SQ + INN T P +
Sbjct: 69 TTTLEKLLLFIGTLVAVITGAGLPLMSILQGKVSQAFINEQIVINNNGSTFLPTGQNYTK 128
Query: 3501 KLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFD 3322
FE D+ VV + + + G + + +V + +RR+++ +LR++IS+FD
Sbjct: 129 TDFEHDVMNVVWSYAAMTVGMWAAGQITVTCYLYVAEQMNNRLRREFVKSILRQEISWFD 188
Query: 3321 GMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFG 3142
+G L+ L DN+ER +E +KI + L+ F+ G I+AF W+L +
Sbjct: 189 TNHSGTLATKLFDNLERVKEGTGDKIGMAFQYLSQFITGFIVAFTHSWQLTLVMLAVTPI 248
Query: 3141 IVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNG 2962
L G + ++ + AG + + + +TV SLNG + E+ERY+ ++
Sbjct: 249 QALCGFAIAKSMSTFAIRETLRYAKAGKVVEETISSIRTVVSLNGLRYELERYSTAVEEA 308
Query: 2961 EKYALNRAFVFSLS---RSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFG 2791
+K + + +S A F + AL F Y G +++G++ G ++ ++ G
Sbjct: 309 KKAGVLKGLFLGISFGAMQASNFISFALAF---YIGVGWVHDGSLNFGDMLTTFSSVMMG 365
Query: 2790 SYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIKDT-FQGIISFKNVLFS 2614
S LG A ++ L +A I ++L D D KD +G I+ +NV F+
Sbjct: 366 SMALGLAGPQLAVLGTAQGAASGIYEVL-DRKPVIDSSSKAGRKDMKIKGDITVENVHFT 424
Query: 2613 YPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYN 2434
YP+RPDVP+L+ ++ V G+ +ALVG+SG GKST+I LLL YY++ G+I+IDG D+ +
Sbjct: 425 YPSRPDVPILRGMNLRVNAGQTVALVGSSGCGKSTIISLLLRYYDVLKGKITIDGVDVRD 484
Query: 2433 INIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGI 2254
IN++ LR+ + VV QEP LFN +IEENI GK T +E++ A K ANA F+ P+G
Sbjct: 485 INLEFLRKNVAVVSQEPALFNCTIEENISLGKEGITREEMVAACKMANAEKFIKTLPNGY 544
Query: 2253 KTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGR 2074
T+VG+RG QLSGGQKQRIAIAR LVRNP+ILLLDEATSALD ESE IVQ+AL KA+ GR
Sbjct: 545 NTLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAESEGIVQQALDKAAKGR 604
Query: 2073 TTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNE 1894
TTI++AHRLSTIRNA+ II + G++VEVGDH+ L+A G+Y +LV Q + + E
Sbjct: 605 TTIIIAHRLSTIRNADLIISCKNGQVVEVGDHRALMAQQGLYYDLVTAQTFTDAVDSAAE 664
Query: 1893 ----NEERVTRQSSHSDFPSNEISHQK-------------------IDQED-----DYVK 1798
E V RQ+S + S + S ID+++ D +
Sbjct: 665 GKFSRENSVARQTSEHEGLSRQASEMDDIMNRVRSSTIGSITNGPVIDEKEERIGKDALS 724
Query: 1797 KLIAEIKEEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAF 1618
+L E++E A+K+N+ EI+ + R LFI + + I G YP S +A
Sbjct: 725 RLKQELEENNAQKTNLFEILYHARPHALSLFIGMSTATIGGFIYPTYSVFFTSFMNVFAG 784
Query: 1617 DKDEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAF 1438
+ + LS+ HFWAL L LA + I F +F G +E L+ LR+ F++++S F
Sbjct: 785 NPADFLSQGHFWALMFLVLAAAQGICSFLMTFFMGIASESLTRDLRNKLFRNVLSQHIGF 844
Query: 1437 YDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLM 1258
+D P + + ++S RL D N+ A+D R +VI TLV+++ + ++FFY W+M+L ++
Sbjct: 845 FDSPQNASGKISTRLATDVPNLRTAIDFRFSTVITTLVSMVAGIGLAFFYGWQMALLIIA 904
Query: 1257 FCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSH 1078
P++ Y + + F S + AIEA+ENVRTV+AL E+
Sbjct: 905 ILPIVAFGQYLRGRRFTGKNVKSASEFADSGKIAIEAIENVRTVQALAREDTFYENFCEK 964
Query: 1077 LQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLRE--EILPMDTYLVLMTL 904
L K A IQG + G A S + + +++ G L++ + + PM V+ +
Sbjct: 965 LDIPHKEAIKEAFIQGLSYGCASSVLYLLNTCAYRMGLALIITDPPTMQPMRVLRVMYAI 1024
Query: 903 SMTASYAGSAVAYLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSF 724
+++ S G A +Y P++ KA A G+IF + + + S G++ G++ KNV F
Sbjct: 1025 TISTSTLGFATSYFPEYAKATFAGGIIFGMLRKISKIDSLSLAGEKKKLYGKVIFKNVRF 1084
Query: 723 EYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVV 544
Y +R + IL G+S + G+TLALVGPSG GKST+++LLERFY + GE+ ID +
Sbjct: 1085 AYPERPEIEILKGLSFSVEPGQTLALVGPSGCGKSTVVALLERFYDTLGGEIFIDGSEIK 1144
Query: 543 DVNLHHLRESVSLVSQEPVLFNCSIKENFLFGIS-HNASQLEIDQALKVANAFSFVSQFP 367
+N H R +++VSQEP LF+CSI EN ++G+ + + ++++A ++AN +F+++ P
Sbjct: 1145 TLNPEHTRSQIAIVSQEPTLFDCSIAENIIYGLDPSSVTMAQVEEAARLANIHNFIAELP 1204
Query: 366 QGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTAS 187
+G +T VG+RG QLSGGQKQRIAIARA++RNPK+LLLDEATSALD++SEKVVQ ALD A
Sbjct: 1205 EGFETRVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEKVVQEALDRAR 1264
Query: 186 ERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
E + +V+AHRL+TV+NAD IAV+ NG + E+GTH +L+ ++ Y++L QKQ
Sbjct: 1265 EGRTCIVIAHRLNTVMNADCIAVVSNGTIIEKGTHTQLMSEKGAYYKLTQKQ 1316
Score = 308 bits (790), Expect = 5e-82
Identities = 217/612 (35%), Positives = 318/612 (51%), Gaps = 15/612 (2%)
Frame = -1
Query: 3714 NFLKKTFGFQIKCTTRYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNK 3535
N +KT F+I R L F+G+ + + G P S V T+ +N
Sbjct: 733 NNAQKTNLFEILYHARPHALSLFIGMSTATIGGFIYPTYS----------VFFTSFMNVF 782
Query: 3534 TIDPVDLAHAYKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYIS 3355
+P D F S + L+F ++ A FL M ++ ++R +
Sbjct: 783 AGNPAD-------FLSQGHFWALMFLVLAAAQGICSFLMTFFMGIASESLTRDLRNKLFR 835
Query: 3354 RLLRKDISYFDGM--STGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTD 3181
+L + I +FD ++G +S L ++ R + + + +I L V G LAF+
Sbjct: 836 NVLSQHIGFFDSPQNASGKISTRLATDVPNLRTAIDFRFSTVITTLVSMVAGIGLAFFYG 895
Query: 3180 WRLA----CYGTVFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSL 3013
W++A + +FG L G + GK N K +++G IA +A+ +TV +L
Sbjct: 896 WQMALLIIAILPIVAFGQYLRGRRFT-GK---NVKSASEFADSGKIAIEAIENVRTVQAL 951
Query: 3012 NGQQQEVERYTEELKNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEG--T 2839
+ E + E+L K A+ AF+ LS LN G +I T
Sbjct: 952 AREDTFYENFCEKLDIPHKEAIKEAFIQGLSYGCASSVLYLLNTCAYRMGLALIITDPPT 1011
Query: 2838 IEPGVVVRILYYILFGSYCLGEAILHISRLASAIPLTVPIADIL-----LDSDATADEFF 2674
++P V+R++Y I + LG A + A A I +L +DS + A E
Sbjct: 1012 MQPMRVLRVMYAITISTSTLGFATSYFPEYAKATFAGGIIFGMLRKISKIDSLSLAGE-- 1069
Query: 2673 SEEIKDTFQGIISFKNVLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLL 2494
K G + FKNV F+YP RP++ +LK +SF+V+ G+ +ALVG SG GKSTV+ LL
Sbjct: 1070 ----KKKLYGKVIFKNVRFAYPERPEIEILKGLSFSVEPGQTLALVGPSGCGKSTVVALL 1125
Query: 2493 LHYYNIDSGRISIDGNDIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFG--KPDATEQ 2320
+Y+ G I IDG++I +N + R + +V QEP LF+ SI ENI +G T
Sbjct: 1126 ERFYDTLGGEIFIDGSEIKTLNPEHTRSQIAIVSQEPTLFDCSIAENIIYGLDPSSVTMA 1185
Query: 2319 EIIDALKNANAFDFVCNFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEAT 2140
++ +A + AN +F+ P+G +T VG+RG QLSGGQKQRIAIAR LVRNP+ILLLDEAT
Sbjct: 1186 QVEEAARLANIHNFIAELPEGFETRVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEAT 1245
Query: 2139 SALDNESEFIVQEALQKASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAM 1960
SALD ESE +VQEAL +A GRT IV+AHRL+T+ NA+ I V+ G I+E G H QL++
Sbjct: 1246 SALDTESEKVVQEALDRAREGRTCIVIAHRLNTVMNADCIAVVSNGTIIEKGTHTQLMSE 1305
Query: 1959 NGVYNNLVQTQL 1924
G Y L Q Q+
Sbjct: 1306 KGAYYKLTQKQM 1317
>gi|283551|pir||S27337 multidrug resistance protein A - Caenorhabditis
elegans
gi|6809|emb|CAA46190.1| P-glycoprotein A [Caenorhabditis elegans]
Length = 1321
Score = 823 bits (2125), Expect = 0.0
Identities = 477/1252 (38%), Positives = 725/1252 (57%), Gaps = 37/1252 (2%)
Frame = -1
Query: 3675 TTRYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNK--TIDPVDLAHAY 3502
TT EKLL F+G + +++TG P S G+ SQ + INN T P +
Sbjct: 69 TTTLEKLLLFIGTLVAVITGAGLPLMSILQGKVSQAFINEQIVINNNGSTFLPTGQNYTK 128
Query: 3501 KLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFD 3322
FE D+ VV + + + G + + +V + +RR+++ +LR++IS+FD
Sbjct: 129 TDFEHDVMNVVWSYAAMTVGMWAAGQIIVTCYLYVAEQMNNRLRREFVKSILRQEISWFD 188
Query: 3321 GMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFG 3142
+G L+ L DN+ER +E +KI + L+ F+ G I+AF W+L +
Sbjct: 189 TNHSGTLATKLFDNLERVKEGTGDKIGMAFQYLSQFITGFIVAFTHSWQLTLVMLAVTPI 248
Query: 3141 IVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNG 2962
L G + ++ + AG + + + +TV SLNG + E+ERY+ ++
Sbjct: 249 QALCGFAIAKSMSTFAIRETLRYAKAGKVVEETISSIRTVVSLNGLRYELERYSTAVEEA 308
Query: 2961 EKYALNRAFVFSLS---RSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFG 2791
+K + + +S A F + AL F Y G +++G++ G ++ ++ G
Sbjct: 309 KKAGVLKGLFLGISFGAMQASNFISFALAF---YIGVGWVHDGSLNFGDMLTTFSSVMMG 365
Query: 2790 SYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIKDT-FQGIISFKNVLFS 2614
S LG A ++ L +A I ++L D D KD +G I+ +NV F+
Sbjct: 366 SMALGLAGPQLAVLGTAQGAASGIYEVL-DRKPVIDSSSKAGRKDMKIKGDITVENVHFT 424
Query: 2613 YPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYN 2434
YP+RPDVP+L+ ++ V G+ +ALVG+SG GKST+I LLL YY++ G+I+IDG D+ +
Sbjct: 425 YPSRPDVPILRGMNLRVNAGQTVALVGSSGCGKSTIISLLLRYYDVLKGKITIDGVDVRD 484
Query: 2433 INIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGI 2254
IN++ LR+ + VV QEP LFN +IEENI GK T +E++ A K ANA F+ P+G
Sbjct: 485 INLEFLRKNVAVVSQEPALFNCTIEENISLGKEGITREEMVAACKMANAEKFIKTLPNGY 544
Query: 2253 KTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGR 2074
T+VG+RG QLSGGQKQRIAIAR LVRNP+ILLLDEATSALD ESE IVQ+AL KA+ GR
Sbjct: 545 NTLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAESEGIVQQALDKAAKGR 604
Query: 2073 TTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNE 1894
TTI++AHRLSTIRNA+ II + G++VEVGDH+ L+A G+Y +LV Q + + E
Sbjct: 605 TTIIIAHRLSTIRNADLIISCKNGQVVEVGDHRALMAQQGLYYDLVTAQTFTDAVDSAAE 664
Query: 1893 ----NEERVTRQSSHSDFPSNEISHQK-------------------IDQED-----DYVK 1798
E V RQ+S + S + S ID+++ D +
Sbjct: 665 GKFSRENSVARQTSEHEGLSRQASEMDDIMNRVRSSTIGSITNGPVIDEKEERIGKDALS 724
Query: 1797 KLIAEIKEEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAF 1618
+L E++E A+K+N+ EI+ + R LFI + + I G YP S +A
Sbjct: 725 RLKQELEENNAQKTNLFEILYHARPHALSLFIGMSTATIGGFIYPTYSVFFTSFMNVFAG 784
Query: 1617 DKDEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAF 1438
+ + LS+ HFWAL L LA + I F +F G +E L+ LR+ F++++S F
Sbjct: 785 NPADFLSQGHFWALMFLVLAAAQGICSFLMTFFMGIASESLTRDLRNKLFRNVLSQHIGF 844
Query: 1437 YDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLM 1258
+D P + + ++S RL D N+ A+D R +VI TLV+++ + ++FFY W+M+L ++
Sbjct: 845 FDSPQNASGKISTRLATDVPNLRTAIDFRFSTVITTLVSMVAGIGLAFFYGWQMALLIIA 904
Query: 1257 FCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSH 1078
P++ Y + + F S + AIEA+ENVRTV+AL E+
Sbjct: 905 ILPIVAFGQYLRGRRFTGKNVKSASEFADSGKIAIEAIENVRTVQALAREDTFYENFCEK 964
Query: 1077 LQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLRE--EILPMDTYLVLMTL 904
L K A IQG + G A S + + +++ G L++ + + PM V+ +
Sbjct: 965 LDIPHKEAIKEAFIQGLSYGCASSVLYLLNTCAYRMGLALIITDPPTMQPMRVLRVMYAI 1024
Query: 903 SMTASYAGSAVAYLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSF 724
+++ S G A +Y P++ KA A G+IF + + + S G++ G++ KNV F
Sbjct: 1025 TISTSTLGFATSYFPEYAKATFAGGIIFGMLRKISKIDSLSLAGEKKKLYGKVIFKNVRF 1084
Query: 723 EYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVV 544
Y +R + IL G+S + G+TLALVGPSG GKST+++LLERFY + GE+ ID +
Sbjct: 1085 AYPERPEIEILKGLSFSVEPGQTLALVGPSGCGKSTVVALLERFYDTLGGEIFIDGSEIK 1144
Query: 543 DVNLHHLRESVSLVSQEPVLFNCSIKENFLFGIS-HNASQLEIDQALKVANAFSFVSQFP 367
+N H R +++VSQEP LF+CSI EN ++G+ + + ++++A ++AN +F+++ P
Sbjct: 1145 TLNPEHTRSQIAIVSQEPTLFDCSIAENIIYGLDPSSVTMAQVEEAARLANIHNFIAELP 1204
Query: 366 QGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTAS 187
+G +T VG+RG QLSGGQKQRIAIARA++RNPK+LLLDEATSALD++SEKVVQ ALD A
Sbjct: 1205 EGFETRVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEKVVQEALDRAR 1264
Query: 186 ERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
E + +V+AHRL+TV+NAD IAV+ NG + E+GTH +L+ ++ Y++L QKQ
Sbjct: 1265 EGRTCIVIAHRLNTVMNADCIAVVSNGTIIEKGTHTQLMSEKGAYYKLTQKQ 1316
Score = 308 bits (790), Expect = 5e-82
Identities = 217/612 (35%), Positives = 318/612 (51%), Gaps = 15/612 (2%)
Frame = -1
Query: 3714 NFLKKTFGFQIKCTTRYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNK 3535
N +KT F+I R L F+G+ + + G P S V T+ +N
Sbjct: 733 NNAQKTNLFEILYHARPHALSLFIGMSTATIGGFIYPTYS----------VFFTSFMNVF 782
Query: 3534 TIDPVDLAHAYKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYIS 3355
+P D F S + L+F ++ A FL M ++ ++R +
Sbjct: 783 AGNPAD-------FLSQGHFWALMFLVLAAAQGICSFLMTFFMGIASESLTRDLRNKLFR 835
Query: 3354 RLLRKDISYFDGM--STGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTD 3181
+L + I +FD ++G +S L ++ R + + + +I L V G LAF+
Sbjct: 836 NVLSQHIGFFDSPQNASGKISTRLATDVPNLRTAIDFRFSTVITTLVSMVAGIGLAFFYG 895
Query: 3180 WRLA----CYGTVFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSL 3013
W++A + +FG L G + GK N K +++G IA +A+ +TV +L
Sbjct: 896 WQMALLIIAILPIVAFGQYLRGRRFT-GK---NVKSASEFADSGKIAIEAIENVRTVQAL 951
Query: 3012 NGQQQEVERYTEELKNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEG--T 2839
+ E + E+L K A+ AF+ LS LN G +I T
Sbjct: 952 AREDTFYENFCEKLDIPHKEAIKEAFIQGLSYGCASSVLYLLNTCAYRMGLALIITDPPT 1011
Query: 2838 IEPGVVVRILYYILFGSYCLGEAILHISRLASAIPLTVPIADIL-----LDSDATADEFF 2674
++P V+R++Y I + LG A + A A I +L +DS + A E
Sbjct: 1012 MQPMRVLRVMYAITISTSTLGFATSYFPEYAKATFAGGIIFGMLRKISKIDSLSLAGE-- 1069
Query: 2673 SEEIKDTFQGIISFKNVLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLL 2494
K G + FKNV F+YP RP++ +LK +SF+V+ G+ +ALVG SG GKSTV+ LL
Sbjct: 1070 ----KKKLYGKVIFKNVRFAYPERPEIEILKGLSFSVEPGQTLALVGPSGCGKSTVVALL 1125
Query: 2493 LHYYNIDSGRISIDGNDIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFG--KPDATEQ 2320
+Y+ G I IDG++I +N + R + +V QEP LF+ SI ENI +G T
Sbjct: 1126 ERFYDTLGGEIFIDGSEIKTLNPEHTRSQIAIVSQEPTLFDCSIAENIIYGLDPSSVTMA 1185
Query: 2319 EIIDALKNANAFDFVCNFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEAT 2140
++ +A + AN +F+ P+G +T VG+RG QLSGGQKQRIAIAR LVRNP+ILLLDEAT
Sbjct: 1186 QVEEAARLANIHNFIAELPEGFETRVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEAT 1245
Query: 2139 SALDNESEFIVQEALQKASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAM 1960
SALD ESE +VQEAL +A GRT IV+AHRL+T+ NA+ I V+ G I+E G H QL++
Sbjct: 1246 SALDTESEKVVQEALDRAREGRTCIVIAHRLNTVMNADCIAVVSNGTIIEKGTHTQLMSE 1305
Query: 1959 NGVYNNLVQTQL 1924
G Y L Q Q+
Sbjct: 1306 KGAYYKLTQKQM 1317
>gi|39595370|emb|CAE60408.1| Hypothetical protein CBG04013
[Caenorhabditis briggsae]
Length = 1265
Score = 800 bits (2065), Expect = 0.0
Identities = 450/1221 (36%), Positives = 708/1221 (57%), Gaps = 10/1221 (0%)
Frame = -1
Query: 3657 LLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNA--------INNKTIDPVDLAHAY 3502
+L +G + +++ G P + LG + V ++ N+ +N ++P+ +
Sbjct: 48 ILLIVGTIAAVIHGAGFPLLAIVLGGMTTVFLRAQNSDFVVGVGNVNPNGLEPISIDE-- 105
Query: 3501 KLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFD 3322
F S++ + + + ++G A F ++Q + + +N + +R+ Y+ +LR+ I +FD
Sbjct: 106 --FNSEVVKYCIYYLILGVAMFVTSYVQIACFESYAENLVHKLRQNYLKAILRQQIQWFD 163
Query: 3321 GMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFG 3142
TG+L+ L D++ER RE +K AL++ + F+ G + F+ W + F+
Sbjct: 164 KQQTGNLTARLTDDLERVREGLGDKFALLVQMFAAFLAGYGVGFFYSWSMTLVMMGFAPL 223
Query: 3141 IVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNG 2962
IVLSG S + + E + AG+IA + +TV SLNG ++E++R+ L+NG
Sbjct: 224 IVLSGAKMSKSMATRTKVEQETYAVAGAIAEETFSSIRTVHSLNGHKRELDRFWNALENG 283
Query: 2961 EKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIY-EGTIEPGVVVRILYYILFGSY 2785
K + + + + + ++G+ +I + T + G++ + + +L GS
Sbjct: 284 RKTGIVKYCYMGIGVGFSNLCMYSSYALAFWYGSTLIINDPTFDRGLIFTVFFAVLSGST 343
Query: 2784 CLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYP 2608
LG A+ H++ +A + ++ +S D + E + D +G ISF+NV F YP
Sbjct: 344 SLGGALPHLASFGTARGAAYTVLRVI-NSHPKIDPYSLEGLLVDNMKGDISFQNVHFRYP 402
Query: 2607 TRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNIN 2428
+R D+PVLK IS V+ GE IALVG+SG GKST++ LL +Y+ G++SIDG D+ IN
Sbjct: 403 SRKDIPVLKGISLEVKSGEKIALVGSSGCGKSTIVNLLQRFYDPTKGKVSIDGVDLKEIN 462
Query: 2427 IKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKT 2248
+ LR+ +G+V QEPVLF+ +I ENI+ G AT ++++A K ANA DF+ PDG T
Sbjct: 463 VHSLREQIGIVSQEPVLFDGTIYENIKMGNEHATHDQVVEACKMANANDFIKRLPDGYGT 522
Query: 2247 IVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTT 2068
VGE+G QLSGGQKQRIAIAR LV+NP+ILLLDEATSALD E+E VQ AL +A GRTT
Sbjct: 523 RVGEKGVQLSGGQKQRIAIARALVKNPKILLLDEATSALDTEAEREVQAALDQAQAGRTT 582
Query: 2067 IVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNENE 1888
++VAHRLSTIRN +KI V + G IVE G H++L+ GV+ ++ Q Q++ ++ ++
Sbjct: 583 LIVAHRLSTIRNVDKIFVFKAGNIVETGSHEELMNKQGVFYDMTQAQVVRQQQQEAGKDI 642
Query: 1887 ERVTRQSSHSDFPSNEISHQKIDQEDDYVKKLIAEIKEEGAKKSNICEIIKYCRSEYCIL 1708
E +S+HS + I + +L E++E A + I +I + R +
Sbjct: 643 EDTISESAHSHLSRKSSTRSAISMATS-IHQLAEEVEECKAPPTPISKIFNFNRDKIWWF 701
Query: 1707 FIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWALSILFLAFTRPIFIFFQ 1528
+ G+ I G P+ + + + + Y+ ++M S +FW + + T I F
Sbjct: 702 IGGMFGAFIFGSVTPVFALVYAEIFNVYSEPVEQMQSDVYFWCGMFVLMGITFFIGFFIS 761
Query: 1527 YYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRL 1348
G+ E L++KLR +FK+LM AFYDD H +L R D+ NV V RL
Sbjct: 762 ANCLGRCGESLTMKLRFEAFKNLMRQDIAFYDDLRHGTGKLCTRFATDAPNVRY-VFTRL 820
Query: 1347 GSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKS 1168
V+ ++V IL A+ + F+Y W+++L +++ PLL + GY D+ E++
Sbjct: 821 PVVLASIVTILGALGIGFYYGWQLALILVVMVPLLVMGGYFEMQMRFGKQIRDTQLLEEA 880
Query: 1167 NRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIY 988
+ A +A+E++RTV +LN + + +L++ N+ K A G F+ S FF+Y
Sbjct: 881 GKVASQAVEHIRTVHSLNRQEQFHFTYCEYLREPFNTNLKHAHTYGAVFAFSQSLIFFMY 940
Query: 987 AVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFHLFT 808
AV+F G+ V + + P+D Y V +S G+ +++PD KA AA L+F+L
Sbjct: 941 AVAFYLGSIFVNQHSMQPIDVYRVFFAISFCGQMIGNTTSFIPDVVKARLAASLLFYLIE 1000
Query: 807 YPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGS 628
+P + S G G I ++N+ F Y R + +L G ++ + G+T+ALVG SG
Sbjct: 1001 HPTPIDSLSEAGIVKPITGNISIRNIFFNYPTRKETKVLQGFTIDIKPGQTVALVGHSGC 1060
Query: 627 GKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFG 448
GKSTI+ LLERFY+ G + ID +N+ ++N+ LR+ V +VSQEP LF+C+I EN +G
Sbjct: 1061 GKSTIMGLLERFYNQDKGMIMIDGDNIRNLNISSLRQQVCIVSQEPTLFDCTIGENICYG 1120
Query: 447 ISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPK 268
+ N + EI +A K+AN +F+ P G DT VGE+G QLSGGQKQRIAIARA++R+P
Sbjct: 1121 TNRNVTYQEIVEAAKMANIHNFILGLPDGYDTHVGEKGTQLSGGQKQRIAIARALVRSPS 1180
Query: 267 VLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQG 88
VLLLDEATSALD++SEK+VQ ALD A + + +V+AHRLST+ N+D IA++ GK+ ++G
Sbjct: 1181 VLLLDEATSALDTESEKIVQEALDAAKQGRTCLVIAHRLSTIQNSDVIAIVSEGKIVDKG 1240
Query: 87 THEELLRKRSIYWRLVQKQGI 25
TH+EL+RK IY +L + Q I
Sbjct: 1241 THDELMRKSEIYQKLCETQRI 1261
Score = 319 bits (817), Expect = 4e-85
Identities = 189/532 (35%), Positives = 293/532 (54%), Gaps = 2/532 (0%)
Frame = -1
Query: 1611 DEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYD 1432
DE S+ + + L L + + Q F AE L KLR K ++ ++D
Sbjct: 104 DEFNSEVVKYCIYYLILGVAMFVTSYVQIACFESYAENLVHKLRQNYLKAILRQQIQWFD 163
Query: 1431 DPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFC 1252
L+ RL D V + D+ ++ A L + FFYSW M+L ++ F
Sbjct: 164 K--QQTGNLTARLTDDLERVREGLGDKFALLVQMFAAFLAGYGVGFFYSWSMTLVMMGFA 221
Query: 1251 PLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQ 1072
PL+ L+G + + + + + A E ++RTV +LN R + + L+
Sbjct: 222 PLIVLSGAKMSKSMATRTKVEQETYAVAGAIAEETFSSIRTVHSLNGHKRELDRFWNALE 281
Query: 1071 KIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTA 892
R + + G GF+ C + YA++F +G+ L++ + + ++
Sbjct: 282 NGRKTGIVKYCYMGIGVGFSNLCMYSSYALAFWYGSTLIINDPTFDRGLIFTVFFAVLSG 341
Query: 891 SYA-GSAVAYLPDHRKAIHAAGLIFHLF-TYPAIMPYDSSQGKRNIKNGEIELKNVSFEY 718
S + G A+ +L A AA + + ++P I PY + G+I +NV F Y
Sbjct: 342 STSLGGALPHLASFGTARGAAYTVLRVINSHPKIDPYSLEGLLVDNMKGDISFQNVHFRY 401
Query: 717 AQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDV 538
R D +L G+SL++ +G +ALVG SG GKSTI++LL+RFY G+V ID ++ ++
Sbjct: 402 PSRKDIPVLKGISLEVKSGEKIALVGSSGCGKSTIVNLLQRFYDPTKGKVSIDGVDLKEI 461
Query: 537 NLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGL 358
N+H LRE + +VSQEPVLF+ +I EN G H A+ ++ +A K+ANA F+ + P G
Sbjct: 462 NVHSLREQIGIVSQEPVLFDGTIYENIKMGNEH-ATHDQVVEACKMANANDFIKRLPDGY 520
Query: 357 DTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERL 178
T VGE+G QLSGGQKQRIAIARA+++NPK+LLLDEATSALD+++E+ VQ ALD A
Sbjct: 521 GTRVGEKGVQLSGGQKQRIAIARALVKNPKILLLDEATSALDTEAEREVQAALDQAQAGR 580
Query: 177 STVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQ 22
+T++VAHRLST+ N D I V K G + E G+HEEL+ K+ +++ + Q Q ++
Sbjct: 581 TTLIVAHRLSTIRNVDKIFVFKAGNIVETGSHEELMNKQGVFYDMTQAQVVR 632
>gi|17508505|ref|NP_491707.1| P-GlycoProtein related (pgp-2)
[Caenorhabditis elegans]
gi|15617726|gb|AAB52482.2| P-glycoprotein related protein 2
[Caenorhabditis elegans]
Length = 1265
Score = 782 bits (2020), Expect = 0.0
Identities = 448/1229 (36%), Positives = 706/1229 (56%), Gaps = 12/1229 (0%)
Frame = -1
Query: 3675 TTRYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNA--------INNKTIDPV 3520
T + LL G V +++ G P + LG + V ++ N+ +N + + P+
Sbjct: 42 TQGVDLLLLITGTVAAVIHGAGFPLLAIVLGGMTTVFLRAQNSDFVVGVDNVNPEGLVPI 101
Query: 3519 DLAHAYKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRK 3340
L F S++ + + + ++G F ++Q + + + + +R+ Y+ +LR+
Sbjct: 102 SLDE----FNSEVVKYCIYYLVLGVLMFFTSYVQIACFESYAERLVHKLRQNYLKAILRQ 157
Query: 3339 DISYFDGMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYG 3160
I +FD TG+L+ L D++ER RE +K AL++ + F+ G + F+ W +
Sbjct: 158 QIQWFDKQQTGNLTARLTDDLERVREGLGDKFALLVQMFAAFLAGYGVGFFYSWSMTLVM 217
Query: 3159 TVFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYT 2980
F+ IVLSG S + E + AG+IA + +TV SLNG ++E++R+
Sbjct: 218 MGFAPLIVLSGAKMSKSMATRTRVEQETYAVAGAIAEETFSSIRTVHSLNGHKRELDRFY 277
Query: 2979 EELKNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIY-EGTIEPGVVVRILYY 2803
L+ G + + + + + + ++G+ +I + T + G++ + +
Sbjct: 278 NALEVGRQTGIVKYCYMGIGVGFSNLCMYSSYALAFWYGSTLIINDPTFDRGLIFTVFFA 337
Query: 2802 ILFGSYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKN 2626
+L GS LG A+ H++ +A + ++ +S D + E I D +G ISFK+
Sbjct: 338 VLSGSTSLGGALPHLASFGTARGAASTVLRVI-NSHPKIDPYSLEGILVDNMKGDISFKD 396
Query: 2625 VLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGN 2446
V F YP+R D+ VLK IS ++ G+ IALVG+SG GKST++ LL +Y+ GR+ IDG
Sbjct: 397 VHFRYPSRKDIHVLKGISLELKAGDKIALVGSSGCGKSTIVNLLQRFYDPTKGRVLIDGV 456
Query: 2445 DIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNF 2266
D+ +N+ LR+ +G+V QEPVLF+ +I ENI+ G AT ++++A K ANA DF+
Sbjct: 457 DLREVNVHSLREQIGIVSQEPVLFDGTIYENIKMGNEHATHDQVVEACKMANANDFIKRL 516
Query: 2265 PDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKA 2086
PDG T VGE+G QLSGGQKQRIAIAR LV+NP+ILLLDEATSALD E+E VQ AL +A
Sbjct: 517 PDGYGTRVGEKGVQLSGGQKQRIAIARALVKNPKILLLDEATSALDTEAEREVQGALDQA 576
Query: 2085 SIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYE 1906
GRTTI+VAHRLSTIRN ++I V + G IVE G H++L++ G++ ++ Q Q++ +
Sbjct: 577 QAGRTTIIVAHRLSTIRNVDRIFVFKAGNIVESGSHEELMSKQGIFYDMTQAQVVRQQQQ 636
Query: 1905 KMNENEERVTRQSSHSDFPSNEISHQKIDQEDDYVKKLIAEIKEEGAKKSNICEIIKYCR 1726
+ ++ E +S+HS + I + +L E++E A +++ +I K+
Sbjct: 637 EAGKDIEDTISESAHSHLSRKSSTRSAISIATS-IHQLAEEVEECKAPPTSMFKIFKFNG 695
Query: 1725 SEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWALSILFLAFTRP 1546
+ + G+ I G P+ + + + + Y+ D+M + +FW + + T
Sbjct: 696 DKVGWFIGGIFGAFIFGSVTPVFALVYAEIFNVYSLPADQMQANVYFWCGMFVLMGITFF 755
Query: 1545 IFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTA 1366
+ F G+ E L++KLR +FK+L+ AFYDD H +L R D+ NV
Sbjct: 756 VGFFTSANCLGRCGESLTMKLRFEAFKNLLRQDIAFYDDLRHGTGKLCTRFATDAPNVRY 815
Query: 1365 AVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDS 1186
V RL V+ ++V I A+ + F+Y W+++L +++ PLL + GY D+
Sbjct: 816 -VFTRLPVVLASIVTICGALGIGFYYGWQLALILVVMVPLLVMGGYFEMQMRFGKQIRDT 874
Query: 1185 IAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACS 1006
E++ + A +A+E++RTV +LN + + +L++ N+ K A G F+ S
Sbjct: 875 QLLEEAGKVASQAVEHIRTVHSLNRQEQFHFTYCEYLREPFNTNLKHAHTYGAVFAFSQS 934
Query: 1005 CYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGL 826
FF+YA +F G+ V ++ + P+D Y V +S G+ +++PD KA AA L
Sbjct: 935 LIFFMYAAAFYLGSIFVNQQAMQPIDVYRVFFAISFCGQMIGNTTSFIPDVVKARLAASL 994
Query: 825 IFHLFTYPAIMPYDSSQGKRNIK--NGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTL 652
+F+L +P P DS +K G I ++NV F Y R D +L G +L + AG+T+
Sbjct: 995 LFYLIEHPT--PIDSLSDSGIVKPITGNISIRNVFFNYPTRKDTKVLQGFTLDIKAGKTV 1052
Query: 651 ALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCS 472
ALVG SG GKSTI+ LLERFY+ G + ID +N+ ++N+ LRE V +VSQEP LF+C+
Sbjct: 1053 ALVGHSGCGKSTIMGLLERFYNQDKGMIMIDGDNIRNLNISSLREQVCIVSQEPTLFDCT 1112
Query: 471 IKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIA 292
I EN +G + N + EI +A K+AN +F+ P G DT VGE+G QLSGGQKQRIAIA
Sbjct: 1113 IGENICYGTNRNVTYQEIVEAAKMANIHNFILGLPDGYDTHVGEKGTQLSGGQKQRIAIA 1172
Query: 291 RAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLK 112
RA++R+P VLLLDEATSALD++SEK+VQ ALD A + + +V+AHRLST+ N+D IA++
Sbjct: 1173 RALVRSPSVLLLDEATSALDTESEKIVQEALDAAKQGRTCLVIAHRLSTIQNSDVIAIVS 1232
Query: 111 NGKVAEQGTHEELLRKRSIYWRLVQKQGI 25
GK+ E+GTH+EL+RK IY + + Q I
Sbjct: 1233 EGKIVEKGTHDELIRKSEIYQKFCETQRI 1261
Score = 319 bits (818), Expect = 3e-85
Identities = 190/514 (36%), Positives = 286/514 (54%), Gaps = 6/514 (1%)
Frame = -1
Query: 1545 IFIFFQYYF----FGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSS 1378
+ +FF Y F AE+L KLR K ++ ++D L+ RL D
Sbjct: 122 VLMFFTSYVQIACFESYAERLVHKLRQNYLKAILRQQIQWFDK--QQTGNLTARLTDDLE 179
Query: 1377 NVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAV 1198
V + D+ ++ A L + FFYSW M+L ++ F PL+ L+G +
Sbjct: 180 RVREGLGDKFALLVQMFAAFLAGYGVGFFYSWSMTLVMMGFAPLIVLSGAKMSKSMATRT 239
Query: 1197 EEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANG 1018
+ + + A E ++RTV +LN R + + L+ R + + G G
Sbjct: 240 RVEQETYAVAGAIAEETFSSIRTVHSLNGHKRELDRFYNALEVGRQTGIVKYCYMGIGVG 299
Query: 1017 FACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYA-GSAVAYLPDHRKAI 841
F+ C + YA++F +G+ L++ + + ++ S + G A+ +L A
Sbjct: 300 FSNLCMYSSYALAFWYGSTLIINDPTFDRGLIFTVFFAVLSGSTSLGGALPHLASFGTAR 359
Query: 840 HAAGLIFHLF-TYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPA 664
AA + + ++P I PY + G+I K+V F Y R D +L G+SL+L A
Sbjct: 360 GAASTVLRVINSHPKIDPYSLEGILVDNMKGDISFKDVHFRYPSRKDIHVLKGISLELKA 419
Query: 663 GRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVL 484
G +ALVG SG GKSTI++LL+RFY G V ID ++ +VN+H LRE + +VSQEPVL
Sbjct: 420 GDKIALVGSSGCGKSTIVNLLQRFYDPTKGRVLIDGVDLREVNVHSLREQIGIVSQEPVL 479
Query: 483 FNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQR 304
F+ +I EN G H A+ ++ +A K+ANA F+ + P G T VGE+G QLSGGQKQR
Sbjct: 480 FDGTIYENIKMGNEH-ATHDQVVEACKMANANDFIKRLPDGYGTRVGEKGVQLSGGQKQR 538
Query: 303 IAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSI 124
IAIARA+++NPK+LLLDEATSALD+++E+ VQ ALD A +T++VAHRLST+ N D I
Sbjct: 539 IAIARALVKNPKILLLDEATSALDTEAEREVQGALDQAQAGRTTIIVAHRLSTIRNVDRI 598
Query: 123 AVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQ 22
V K G + E G+HEEL+ K+ I++ + Q Q ++
Sbjct: 599 FVFKAGNIVESGSHEELMSKQGIFYDMTQAQVVR 632
>gi|40644181|emb|CAC86600.1| multidrug resistance protein [Platichthys
flesus]
Length = 1292
Score = 770 bits (1989), Expect = 0.0
Identities = 449/1241 (36%), Positives = 696/1241 (55%), Gaps = 33/1241 (2%)
Frame = -1
Query: 3654 LFFLGVVFSILTGMCQPFESYTLGETSQVLVKV---------TNAINNKTIDPVDLAHAY 3502
+ G V ++ G+ P G+ + LV T N T P++
Sbjct: 60 MILCGTVMAMANGVVLPLMCIVFGDMTDSLVNFPTGEISDNFTVIYPNFTGLPIN----- 114
Query: 3501 KLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFD 3322
+ DMNR + + ++G +LQ S+ +R+ + R++++DI +FD
Sbjct: 115 STLQEDMNRYAIYYSIMGATVLVAAYLQVSLWTMAAGRQVKRIRKLFFHRIMQQDIGWFD 174
Query: 3321 GMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFG 3142
TG L+ L D++ + +E +K A++I T F+ ++ F W+L S
Sbjct: 175 VNETGELNTRLIDDVYKIQEGIGDKAAMLIQAYTTFLSAFVIGFTKGWKLTLVILAVSPA 234
Query: 3141 IVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNG 2962
+ LS L S K+ + AG++A + L +TV + +GQ +E++RY + L++
Sbjct: 235 LGLSAALFSKVLTSFTSKEQAAYAKAGAVAEEVLAAIRTVFAFSGQDREIKRYHKNLEDA 294
Query: 2961 EKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYC 2782
+ + +A ++S + + ++G+ +I G V+ +L+ +L G++
Sbjct: 295 KIMGIKKALSANISMGFTFMVIYLSYALAFWYGSTLILSNEYTIGSVLTVLFVVLIGAFT 354
Query: 2781 LGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPT 2605
+G++ +I ASA + I+ D++ T D + K D+ +G I FKN+ FSYPT
Sbjct: 355 MGQSSANIQTFASARGAAHKVYSII-DNNPTIDSYSEAGFKPDSIKGNIEFKNIHFSYPT 413
Query: 2604 RPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINI 2425
RPDV +LK +S +V+ G+ +ALVG+SG GKST +QLL +Y+ G + +DG+DI ++N+
Sbjct: 414 RPDVQILKNMSLSVKSGQTMALVGSSGCGKSTTVQLLQRFYDPQDGAVFVDGHDIRSLNV 473
Query: 2424 KQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTI 2245
+ LR+ +GVV QEP+LF T+I ENIR+G+ D T+QEI A K ANA+DF+ PD +T+
Sbjct: 474 RYLREMIGVVSQEPILFATTISENIRYGRLDVTDQEIEQAAKEANAYDFIIKLPDKFETL 533
Query: 2244 VGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTI 2065
VG+RG Q+SGGQKQR+AIAR LVRNP+ILLLDEATSALD ESE IVQ AL K +GRTTI
Sbjct: 534 VGDRGTQMSGGQKQRVAIARALVRNPKILLLDEATSALDAESETIVQAALDKVRLGRTTI 593
Query: 2064 VVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNENEE 1885
VVAHRLSTIRNA+ I + G++ EVG H QL+ G+Y LV TQ + E+ E EE
Sbjct: 594 VVAHRLSTIRNADVIAGFQDGQVAEVGTHSQLMEKKGIYQRLVTTQTFQ-DVEEAKEAEE 652
Query: 1884 RVT-------------------RQSSHSDFPSNEISHQKIDQEDDYVKKLIAEIKEEGAK 1762
++ + + S ++E +K + + D + ++E
Sbjct: 653 ELSVDEKSPLADSLSECTPYRRKTTRGSSMSASEGGKEKTESDKDETE------EDENVP 706
Query: 1761 KSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFW 1582
+ ++++ E+ + + + + I G P+ + + K +A +KD+ L +
Sbjct: 707 PVSFLKVLRLNLPEWPYMLVGTVCAIINGAMQPVFAIIFSKIITVFA-EKDQELVRQRAT 765
Query: 1581 ALSILFLAFTRPIFI--FFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATR 1408
S++F F+ F Q + FGK+ E L++KLR +FK +M +++D+P ++
Sbjct: 766 LFSLMFAVIGGVSFVTMFLQGFCFGKSGEILTLKLRLGAFKAMMRQDLSWFDNPKNSVGA 825
Query: 1407 LSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGY 1228
L+ RL D++ V A R+ ++ + +VI+SF Y W+++L +L P + LAG
Sbjct: 826 LTTRLATDAAQVQGATGVRMATLAQNFANLGTSVIISFIYGWELTLLILAVVPAMVLAGA 885
Query: 1227 CNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFK 1048
+ ED EK+ + + EA+EN+RTV +L E + L +L+ + K
Sbjct: 886 VEMKLLTGHAVEDKKELEKAGKISTEAIENIRTVASLTREPKFESLYHKNLEVPYKNSTK 945
Query: 1047 RAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVA 868
+A + G F+ + +F YA F+FG WL+ + +LV+ + A G A +
Sbjct: 946 KAHVYGATFAFSQAMIYFAYAGCFRFGAWLIEEGRMDVQGVFLVISAVLYGAMAIGEANS 1005
Query: 867 YLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGKRNIK-NGEIELKNVSFEYAQRSDKMIL 691
+ P++ KA +A + L + S +G+ + +G + +NV F Y R + +L
Sbjct: 1006 FAPNYAKAKMSASHLMMLMNLEPAIDNLSQEGETPDRFDGNVHFENVRFNYPSRPNLPVL 1065
Query: 690 DGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESV 511
G+ L++ G TLALVG SG GKSTII LLERFY +G V +D N +N+H LR +
Sbjct: 1066 QGLDLEVKRGETLALVGSSGCGKSTIIQLLERFYDPREGSVVLDNVNTKQLNIHWLRSQM 1125
Query: 510 SLVSQEPVLFNCSIKENFLFG-ISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERG 334
+VSQEP LF+C++ +N +G S A+ EI A K AN SF+ + P+ DT G++G
Sbjct: 1126 GIVSQEPTLFDCTLAQNIAYGDNSRIATMDEIVAAAKAANIHSFIQELPEKYDTQAGDKG 1185
Query: 333 AQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHR 154
QLSGGQKQRIAIARAILRNP +LLLDEATSALD++SEKVVQ ALD AS+ + ++VAHR
Sbjct: 1186 TQLSGGQKQRIAIARAILRNPMLLLLDEATSALDTESEKVVQEALDQASKGRTCIIVAHR 1245
Query: 153 LSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
LST+ NAD IAVL+ G V EQGTH++LL KR +Y LV Q
Sbjct: 1246 LSTIQNADRIAVLQGGVVVEQGTHQQLLAKRGVYHMLVTTQ 1286
Score = 320 bits (819), Expect = 2e-85
Identities = 190/522 (36%), Positives = 287/522 (54%), Gaps = 1/522 (0%)
Frame = -1
Query: 1584 WALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRL 1405
+A+ + T + + Q + A + ++R + F +M ++D + L
Sbjct: 124 YAIYYSIMGATVLVAAYLQVSLWTMAAGRQVKRIRKLFFHRIMQQDIGWFD--VNETGEL 181
Query: 1404 SNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYC 1225
+ RL D + + D+ +I L A ++ F WK++L +L P L L+
Sbjct: 182 NTRLIDDVYKIQEGIGDKAAMLIQAYTTFLSAFVIGFTKGWKLTLVILAVSPALGLSAAL 241
Query: 1224 NDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKR 1045
+ ++ A+ K+ A E L +RTV A + ++R I +L+ + K+
Sbjct: 242 FSKVLTSFTSKEQAAYAKAGAVAEEVLAAIRTVFAFSGQDREIKRYHKNLEDAKIMGIKK 301
Query: 1044 AVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAY 865
A+ + GF + YA++F +G+ L+L E VL + + A G + A
Sbjct: 302 ALSANISMGFTFMVIYLSYALAFWYGSTLILSNEYTIGSVLTVLFVVLIGAFTMGQSSAN 361
Query: 864 LPDHRKAIHAAGLIFHLF-TYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILD 688
+ A AA ++ + P I Y + K + G IE KN+ F Y R D IL
Sbjct: 362 IQTFASARGAAHKVYSIIDNNPTIDSYSEAGFKPDSIKGNIEFKNIHFSYPTRPDVQILK 421
Query: 687 GVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVS 508
+SL + +G+T+ALVG SG GKST + LL+RFY DG V +D ++ +N+ +LRE +
Sbjct: 422 NMSLSVKSGQTMALVGSSGCGKSTTVQLLQRFYDPQDGAVFVDGHDIRSLNVRYLREMIG 481
Query: 507 LVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQ 328
+VSQEP+LF +I EN +G Q EI+QA K ANA+ F+ + P +TLVG+RG Q
Sbjct: 482 VVSQEPILFATTISENIRYGRLDVTDQ-EIEQAAKEANAYDFIIKLPDKFETLVGDRGTQ 540
Query: 327 LSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLS 148
+SGGQKQR+AIARA++RNPK+LLLDEATSALD++SE +VQ ALD +T+VVAHRLS
Sbjct: 541 MSGGQKQRVAIARALVRNPKILLLDEATSALDAESETIVQAALDKVRLGRTTIVVAHRLS 600
Query: 147 TVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQ 22
T+ NAD IA ++G+VAE GTH +L+ K+ IY RLV Q Q
Sbjct: 601 TIRNADVIAGFQDGQVAEVGTHSQLMEKKGIYQRLVTTQTFQ 642
Score = 305 bits (780), Expect = 7e-81
Identities = 204/575 (35%), Positives = 311/575 (53%), Gaps = 20/575 (3%)
Frame = -1
Query: 3588 LGETSQVLVKVTNAINNKTIDPVDLAHAYKLF----ESDMNRV-------VLLFFLVGFA 3442
L E +LV AI N + PV K+ E D V L+F ++G
Sbjct: 718 LPEWPYMLVGTVCAIINGAMQPVFAIIFSKIITVFAEKDQELVRQRATLFSLMFAVIGGV 777
Query: 3441 YFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGM--STGHLSIVLNDNMERF 3268
F FLQ G+ +R ++R+D+S+FD S G L+ L + +
Sbjct: 778 SFVTMFLQGFCFGKSGEILTLKLRLGAFKAMMRQDLSWFDNPKNSVGALTTRLATDAAQV 837
Query: 3267 REVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLLDSWGKMKNNEK 3088
+ ++A + + I++F W L +VL+G ++ + +
Sbjct: 838 QGATGVRMATLAQNFANLGTSVIISFIYGWELTLLILAVVPAMVLAGAVEMKLLTGHAVE 897
Query: 3087 QNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNRAFVFSLSRSAD 2908
+ + AG I+ +A+ +TV+SL + + Y + L+ K + +A V+ A
Sbjct: 898 DKKELEKAGKISTEAIENIRTVASLTREPKFESLYHKNLEVPYKNSTKKAHVYG----AT 953
Query: 2907 YFFTNALNFVI----LYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEAILHISRLASA 2740
+ F+ A+ + FGA +I EG ++ V ++ +L+G+ +GEA A A
Sbjct: 954 FAFSQAMIYFAYAGCFRFGAWLIEEGRMDVQGVFLVISAVLYGAMAIGEANSFAPNYAKA 1013
Query: 2739 IPLTVPIADILLDSDATADEFFSE-EIKDTFQGIISFKNVLFSYPTRPDVPVLKEISFNV 2563
++ +L++ + D E E D F G + F+NV F+YP+RP++PVL+ + V
Sbjct: 1014 -KMSASHLMMLMNLEPAIDNLSQEGETPDRFDGNVHFENVRFNYPSRPNLPVLQGLDLEV 1072
Query: 2562 QGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAMGVVFQEP 2383
+ GE +ALVG+SG GKST+IQLL +Y+ G + +D + +NI LR MG+V QEP
Sbjct: 1073 KRGETLALVGSSGCGKSTIIQLLERFYDPREGSVVLDNVNTKQLNIHWLRSQMGIVSQEP 1132
Query: 2382 VLFNTSIEENIRFGKPD--ATEQEIIDALKNANAFDFVCNFPDGIKTIVGERGAQLSGGQ 2209
LF+ ++ +NI +G AT EI+ A K AN F+ P+ T G++G QLSGGQ
Sbjct: 1133 TLFDCTLAQNIAYGDNSRIATMDEIVAAAKAANIHSFIQELPEKYDTQAGDKGTQLSGGQ 1192
Query: 2208 KQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHRLSTIRNA 2029
KQRIAIAR ++RNP +LLLDEATSALD ESE +VQEAL +AS GRT I+VAHRLSTI+NA
Sbjct: 1193 KQRIAIARAILRNPMLLLLDEATSALDTESEKVVQEALDQASKGRTCIIVAHRLSTIQNA 1252
Query: 2028 NKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQL 1924
++I V++ G +VE G H+QL+A GVY+ LV TQ+
Sbjct: 1253 DRIAVLQGGVVVEQGTHQQLLAKRGVYHMLVTTQM 1287
>gi|25297453|pir||D87789 protein C34G6.4 [imported] - Caenorhabditis
elegans
Length = 1289
Score = 769 bits (1986), Expect = 0.0
Identities = 449/1252 (35%), Positives = 708/1252 (55%), Gaps = 35/1252 (2%)
Frame = -1
Query: 3675 TTRYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNA--------INNKTIDPV 3520
T + LL G V +++ G P + LG + V ++ N+ +N + + P+
Sbjct: 42 TQGVDLLLLITGTVAAVIHGAGFPLLAIVLGGMTTVFLRAQNSDFVVGVDNVNPEGLVPI 101
Query: 3519 DLAHAYKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRK 3340
L F S++ + + + ++G F ++Q + + + + +R+ Y+ +LR+
Sbjct: 102 SLDE----FNSEVVKYCIYYLVLGVLMFFTSYVQIACFESYAERLVHKLRQNYLKAILRQ 157
Query: 3339 DISYFDGMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYG 3160
I +FD TG+L+ L D++ER RE +K AL++ + F+ G + F+ W +
Sbjct: 158 QIQWFDKQQTGNLTARLTDDLERVREGLGDKFALLVQMFAAFLAGYGVGFFYSWSMTLVM 217
Query: 3159 TVFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYT 2980
F+ IVLSG S + E + AG+IA + +TV SLNG ++E++R+
Sbjct: 218 MGFAPLIVLSGAKMSKSMATRTRVEQETYAVAGAIAEETFSSIRTVHSLNGHKRELDRFY 277
Query: 2979 EELKNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIY-EGTIEPGVVVRILYY 2803
L+ G + + + + + + ++G+ +I + T + G++ + +
Sbjct: 278 NALEVGRQTGIVKYCYMGIGVGFSNLCMYSSYALAFWYGSTLIINDPTFDRGLIFTVFFA 337
Query: 2802 ILFGSYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKN 2626
+L GS LG A+ H++ +A + ++ +S D + E I D +G ISFK+
Sbjct: 338 VLSGSTSLGGALPHLASFGTARGAASTVLRVI-NSHPKIDPYSLEGILVDNMKGDISFKD 396
Query: 2625 VLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGN 2446
V F YP+R D+ VLK IS ++ G+ IALVG+SG GKST++ LL +Y+ GR+ IDG
Sbjct: 397 VHFRYPSRKDIHVLKGISLELKAGDKIALVGSSGCGKSTIVNLLQRFYDPTKGRVLIDGV 456
Query: 2445 DIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNF 2266
D+ +N+ LR+ +G+V QEPVLF+ +I ENI+ G AT ++++A K ANA DF+
Sbjct: 457 DLREVNVHSLREQIGIVSQEPVLFDGTIYENIKMGNEHATHDQVVEACKMANANDFIKRL 516
Query: 2265 PDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKA 2086
PDG T VGE+G QLSGGQKQRIAIAR LV+NP+ILLLDEATSALD E+E VQ AL +A
Sbjct: 517 PDGYGTRVGEKGVQLSGGQKQRIAIARALVKNPKILLLDEATSALDTEAEREVQGALDQA 576
Query: 2085 SIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYE 1906
GRTTI+VAHRLSTIRN ++I V + G IVE G H++L++ G++ ++ Q Q++ +
Sbjct: 577 QAGRTTIIVAHRLSTIRNVDRIFVFKAGNIVESGSHEELMSKQGIFYDMTQAQVVRQQQQ 636
Query: 1905 KMNENEERVTRQSSHSDFPSNEIS----------HQKIDQED-----------DYVKKLI 1789
+ ++ E +S+HS + HQ ++ + D ++ I
Sbjct: 637 EAGKDIEDTISESAHSHLSRKSSTRSAISIATSIHQLAEEVELIDPFNGQTNQDVIRSRI 696
Query: 1788 AEI--KEEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFD 1615
E A +++ +I K+ + + G+ I G P+ + + + + Y+
Sbjct: 697 LSAFGGECKAPPTSMFKIFKFNGDKVGWFIGGIFGAFIFGSVTPVFALVYAEIFNVYSLP 756
Query: 1614 KDEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFY 1435
D+M + +FW + + T + F G+ E L++KLR +FK+L+ AFY
Sbjct: 757 ADQMQANVYFWCGMFVLMGITFFVGFFTSANCLGRCGESLTMKLRFEAFKNLLRQDIAFY 816
Query: 1434 DDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMF 1255
DD H +L R D+ NV V RL V+ ++V I A+ + F+Y W+++L +++
Sbjct: 817 DDLRHGTGKLCTRFATDAPNVRY-VFTRLPVVLASIVTICGALGIGFYYGWQLALILVVM 875
Query: 1254 CPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHL 1075
PLL + GY D+ E++ + A +A+E++RTV +LN + + +L
Sbjct: 876 VPLLVMGGYFEMQMRFGKQIRDTQLLEEAGKVASQAVEHIRTVHSLNRQEQFHFTYCEYL 935
Query: 1074 QKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMT 895
++ N+ K A G F+ S FF+YA +F G+ V ++ + P+D Y V +S
Sbjct: 936 REPFNTNLKHAHTYGAVFAFSQSLIFFMYAAAFYLGSIFVNQQAMQPIDVYRVFFAISFC 995
Query: 894 ASYAGSAVAYLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGKRNIK--NGEIELKNVSFE 721
G+ +++PD KA AA L+F+L +P P DS +K G I ++NV F
Sbjct: 996 GQMIGNTTSFIPDVVKARLAASLLFYLIEHPT--PIDSLSDSGIVKPITGNISIRNVFFN 1053
Query: 720 YAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVD 541
Y R D +L G +L + AG+T+ALVG SG GKSTI+ LLERFY+ G + ID +N+ +
Sbjct: 1054 YPTRKDTKVLQGFTLDIKAGKTVALVGHSGCGKSTIMGLLERFYNQDKGMIMIDGDNIRN 1113
Query: 540 VNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQG 361
+N+ LRE V +VSQEP LF+C+I EN +G + N + EI +A K+AN +F+ P G
Sbjct: 1114 LNISSLREQVCIVSQEPTLFDCTIGENICYGTNRNVTYQEIVEAAKMANIHNFILGLPDG 1173
Query: 360 LDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASER 181
DT VGE+G QLSGGQKQRIAIARA++R+P VLLLDEATSALD++SEK+VQ ALD A +
Sbjct: 1174 YDTHVGEKGTQLSGGQKQRIAIARALVRSPSVLLLDEATSALDTESEKIVQEALDAAKQG 1233
Query: 180 LSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGI 25
+ +V+AHRLST+ N+D IA++ GK+ E+GTH+EL+RK IY + + Q I
Sbjct: 1234 RTCLVIAHRLSTIQNSDVIAIVSEGKIVEKGTHDELIRKSEIYQKFCETQRI 1285
Score = 319 bits (818), Expect = 3e-85
Identities = 190/514 (36%), Positives = 286/514 (54%), Gaps = 6/514 (1%)
Frame = -1
Query: 1545 IFIFFQYYF----FGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSS 1378
+ +FF Y F AE+L KLR K ++ ++D L+ RL D
Sbjct: 122 VLMFFTSYVQIACFESYAERLVHKLRQNYLKAILRQQIQWFDK--QQTGNLTARLTDDLE 179
Query: 1377 NVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAV 1198
V + D+ ++ A L + FFYSW M+L ++ F PL+ L+G +
Sbjct: 180 RVREGLGDKFALLVQMFAAFLAGYGVGFFYSWSMTLVMMGFAPLIVLSGAKMSKSMATRT 239
Query: 1197 EEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANG 1018
+ + + A E ++RTV +LN R + + L+ R + + G G
Sbjct: 240 RVEQETYAVAGAIAEETFSSIRTVHSLNGHKRELDRFYNALEVGRQTGIVKYCYMGIGVG 299
Query: 1017 FACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYA-GSAVAYLPDHRKAI 841
F+ C + YA++F +G+ L++ + + ++ S + G A+ +L A
Sbjct: 300 FSNLCMYSSYALAFWYGSTLIINDPTFDRGLIFTVFFAVLSGSTSLGGALPHLASFGTAR 359
Query: 840 HAAGLIFHLF-TYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPA 664
AA + + ++P I PY + G+I K+V F Y R D +L G+SL+L A
Sbjct: 360 GAASTVLRVINSHPKIDPYSLEGILVDNMKGDISFKDVHFRYPSRKDIHVLKGISLELKA 419
Query: 663 GRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVL 484
G +ALVG SG GKSTI++LL+RFY G V ID ++ +VN+H LRE + +VSQEPVL
Sbjct: 420 GDKIALVGSSGCGKSTIVNLLQRFYDPTKGRVLIDGVDLREVNVHSLREQIGIVSQEPVL 479
Query: 483 FNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQR 304
F+ +I EN G H A+ ++ +A K+ANA F+ + P G T VGE+G QLSGGQKQR
Sbjct: 480 FDGTIYENIKMGNEH-ATHDQVVEACKMANANDFIKRLPDGYGTRVGEKGVQLSGGQKQR 538
Query: 303 IAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSI 124
IAIARA+++NPK+LLLDEATSALD+++E+ VQ ALD A +T++VAHRLST+ N D I
Sbjct: 539 IAIARALVKNPKILLLDEATSALDTEAEREVQGALDQAQAGRTTIIVAHRLSTIRNVDRI 598
Query: 123 AVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQ 22
V K G + E G+HEEL+ K+ I++ + Q Q ++
Sbjct: 599 FVFKAGNIVESGSHEELMSKQGIFYDMTQAQVVR 632
>gi|1362689|pir||S55692 multidrug resistance protein homolog (mdr) -
African clawed frog
Length = 1287
Score = 765 bits (1976), Expect = 0.0
Identities = 455/1239 (36%), Positives = 696/1239 (55%), Gaps = 28/1239 (2%)
Frame = -1
Query: 3663 EKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFESD 3484
+K+L G + S+ G P GE + V V ++ + +A + +
Sbjct: 62 DKMLMLFGTIASLAHGAALPLMMLVFGEMTDSFVNV-GQVDTGNFTWESMINASRELQGQ 120
Query: 3483 MNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMSTGH 3304
M + +GF ++Q S +R + +LR++I +FD G
Sbjct: 121 MTTYAYYYSGLGFGVMLCAYIQISFWTLSAGRQIKKIRSNFFHAVLRQEIGWFDINDAGE 180
Query: 3303 LSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGL 3124
L+ L D++ + E +KIA+++ LT V G I+ F W+L S + LS
Sbjct: 181 LNTRLTDDVSKINEGIGDKIAMLLQSLTTLVTGFIIGFIKGWKLTWVMGAISPIMGLSAA 240
Query: 3123 LDSWGKMKN--NEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYA 2950
+ W K+ + K+ + + AG++A + L +TV + GQ +E+ RY + L++ +K
Sbjct: 241 I--WAKVLSAFTNKELKAYAKAGAVAEEVLSSIRTVFAFGGQNKEIHRYEKNLEDAKKIG 298
Query: 2949 LNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEA 2770
+ +A ++S + A + ++G +I +G G V+ + + ++ G++ +G+
Sbjct: 299 IKKAITANVSIGFAFLMIYAAYSLAFWYGTTLIIDGGYTIGSVLTVFFAVIIGAFAVGQT 358
Query: 2769 ILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPTRPDV 2593
+I A+A I +I+ D+ D F E +K D +G I FKNV+F+YP+R D+
Sbjct: 359 SPNIEAFANARGAAYTIFNII-DNQPKIDSFSKEGLKPDKIKGDIEFKNVIFTYPSRKDI 417
Query: 2592 PVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLR 2413
VLK ++ N+ G+ +ALVG+SG GKST +QL+ +Y+ + G I++DG DI ++NI+ LR
Sbjct: 418 QVLKGLNLNIPSGKTVALVGSSGCGKSTTVQLIQRFYDPEDGVITLDGQDIRSLNIRYLR 477
Query: 2412 QAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGER 2233
+ +GVV QEP+LF+T+I +NIR+G+ D T++EI A K ANA+DF+ PD ++T+VGER
Sbjct: 478 EIIGVVSQEPILFDTTIADNIRYGREDVTKEEIERATKEANAYDFIMKLPDKLETLVGER 537
Query: 2232 GAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAH 2053
G QLSGGQKQRIAIAR LVRNP+ILLLDEATSALD ESE +VQ AL KA GRTTIVVAH
Sbjct: 538 GTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQSALDKAREGRTTIVVAH 597
Query: 2052 RLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTN-----------YE 1906
RLSTIRNAN I + G IVE G HK+L+ GVY NLV Q + T+ YE
Sbjct: 598 RLSTIRNANAIAGFDNGVIVEQGSHKELMERGGVYFNLVTLQTVETSKDTEEDLETHIYE 657
Query: 1905 K----MNENEERVTRQSSHSDFPSN--EISHQKIDQEDDYVKKLIAEIKEEGAKKSNICE 1744
K + + V R+SS + S E +++D+E+ KK KEEG + +
Sbjct: 658 KKIPVTHTHSNLVRRKSSRNTIKSKVPETEDKEVDEEE---KK-----KEEGPPPVSFFK 709
Query: 1743 IIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWALSILF 1564
++K + E+ + V+ + I G P + + + +A +M S+S ++L L
Sbjct: 710 VMKLNKPEWPYFVVGVICAMINGATQPAFAIIFSRIIGVFAGPVSQMRSESSMYSLLFLA 769
Query: 1563 LAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNAD 1384
L I F Q + FGK E L+++LR SFK ++ ++DD ++ L+ RL D
Sbjct: 770 LGGVSFITFFLQRFTFGKAGEILTMRLRLGSFKSMLRQEIGWFDDSKNSTGALTTRLATD 829
Query: 1383 SSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQ 1204
+S V A RL + + + A+I+SF Y W+++L +L P++ AG
Sbjct: 830 ASQVQGATGTRLALLAQNVANLGTAIIISFIYGWQLTLLILAIVPVIAAAGLVEMKMFAG 889
Query: 1203 AVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTA 1024
++D EK+ + + +A+ N+RTV +L E + + L+ + K+A + G
Sbjct: 890 HAKKDKKELEKAGKISTDAVLNIRTVVSLTRERKFEAMYEKSLEGPYRNSIKKAHLHGLT 949
Query: 1023 NGFA------CSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYL 862
G + C C+ F G +LV+ + + +LV + + A G ++
Sbjct: 950 YGLSQAHHVLCLCWVFSV-----LGAYLVVEGLMKLDEVFLVSSAIVLGAMALGQTSSFA 1004
Query: 861 PDHRKAIHAAGLIFHLF-TYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDG 685
PD+ KA+ +A IF L P I Y K +G + K V+F Y R D +L G
Sbjct: 1005 PDYTKAMISAAHIFSLLERVPQIDSYSDQGEKPKNCSGNVVFKGVNFNYPTRPDITVLQG 1064
Query: 684 VSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSL 505
+ + + G TLALVG SG GKST +SLLERFY +GEV +D +V ++N+ +R + +
Sbjct: 1065 LDISVKQGETLALVGSSGCGKSTTVSLLERFYDPFEGEVLVDGLSVRNLNIQWVRAQMGI 1124
Query: 504 VSQEPVLFNCSIKENFLFGISH-NASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQ 328
VSQEP+LF+CSI +N +G ++ +Q EI+ A K AN SF+ +T VG++G Q
Sbjct: 1125 VSQEPILFDCSIGDNIAYGDNNRKVTQEEIETAAKEANIHSFIESLTDKYNTRVGDKGTQ 1184
Query: 327 LSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLS 148
LSGGQKQRIAIARA++R PK+LLLDEATSALD++SEKVVQ ALD A + +V+AHRLS
Sbjct: 1185 LSGGQKQRIAIARALIRKPKILLLDEATSALDTESEKVVQEALDKARMGRTCIVIAHRLS 1244
Query: 147 TVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
T+ NAD IAV++NGKV EQGTH++LL+ + +Y+ LV Q
Sbjct: 1245 TIQNADKIAVIQNGKVVEQGTHQQLLQLKGVYFSLVTIQ 1283
Score = 326 bits (836), Expect = 2e-87
Identities = 186/515 (36%), Positives = 298/515 (57%), Gaps = 1/515 (0%)
Frame = -1
Query: 1563 LAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNAD 1384
L F + + Q F+ +A + K+RS F ++ ++D + A L+ RL D
Sbjct: 131 LGFGVMLCAYIQISFWTLSAGRQIKKIRSNFFHAVLRQEIGWFD--INDAGELNTRLTDD 188
Query: 1383 SSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQ 1204
S + + D++ ++ +L ++ I+ F WK++ + P++ L+ +
Sbjct: 189 VSKINEGIGDKIAMLLQSLTTLVTGFIIGFIKGWKLTWVMGAISPIMGLSAAIWAKVLSA 248
Query: 1203 AVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTA 1024
++ A+ K+ A E L ++RTV A +N+ I +L+ + K+A+ +
Sbjct: 249 FTNKELKAYAKAGAVAEEVLSSIRTVFAFGGQNKEIHRYEKNLEDAKKIGIKKAITANVS 308
Query: 1023 NGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKA 844
GFA + Y+++F +GT L++ V + + A G + A
Sbjct: 309 IGFAFLMIYAAYSLAFWYGTTLIIDGGYTIGSVLTVFFAVIIGAFAVGQTSPNIEAFANA 368
Query: 843 IHAAGLIFHLF-TYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLP 667
AA IF++ P I + K + G+IE KNV F Y R D +L G++L +P
Sbjct: 369 RGAAYTIFNIIDNQPKIDSFSKEGLKPDKIKGDIEFKNVIFTYPSRKDIQVLKGLNLNIP 428
Query: 666 AGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPV 487
+G+T+ALVG SG GKST + L++RFY DG + +D +++ +N+ +LRE + +VSQEP+
Sbjct: 429 SGKTVALVGSSGCGKSTTVQLIQRFYDPEDGVITLDGQDIRSLNIRYLREIIGVVSQEPI 488
Query: 486 LFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQ 307
LF+ +I +N +G + ++ EI++A K ANA+ F+ + P L+TLVGERG QLSGGQKQ
Sbjct: 489 LFDTTIADNIRYG-REDVTKEEIERATKEANAYDFIMKLPDKLETLVGERGTQLSGGQKQ 547
Query: 306 RIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADS 127
RIAIARA++RNPK+LLLDEATSALD++SE VVQ+ALD A E +T+VVAHRLST+ NA++
Sbjct: 548 RIAIARALVRNPKILLLDEATSALDTESEAVVQSALDKAREGRTTIVVAHRLSTIRNANA 607
Query: 126 IAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQ 22
IA NG + EQG+H+EL+ + +Y+ LV Q ++
Sbjct: 608 IAGFDNGVIVEQGSHKELMERGGVYFNLVTLQTVE 642
Score = 302 bits (773), Expect = 5e-80
Identities = 202/595 (33%), Positives = 312/595 (51%), Gaps = 6/595 (1%)
Frame = -1
Query: 3690 FQIKCTTRYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLA 3511
F++ + E F +GV+ +++ G QP + V A
Sbjct: 708 FKVMKLNKPEWPYFVVGVICAMINGATQPAFAIIFSRIIGVF-----------------A 750
Query: 3510 HAYKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDIS 3331
S+ + LLF +G F FLQ G+ +R +LR++I
Sbjct: 751 GPVSQMRSESSMYSLLFLALGGVSFITFFLQRFTFGKAGEILTMRLRLGSFKSMLRQEIG 810
Query: 3330 YFDGM--STGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGT 3157
+FD STG L+ L + + + ++AL+ + + I++F W+L
Sbjct: 811 WFDDSKNSTGALTTRLATDASQVQGATGTRLALLAQNVANLGTAIIISFIYGWQLTLLIL 870
Query: 3156 VFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTE 2977
I +GL++ + +K + + AG I+ A+ +TV SL +++ Y +
Sbjct: 871 AIVPVIAAAGLVEMKMFAGHAKKDKKELEKAGKISTDAVLNIRTVVSLTRERKFEAMYEK 930
Query: 2976 ELKNGEKYALNRAFVFSLSRS-ADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYI 2800
L+ + ++ +A + L+ + L +V GA ++ EG ++ V + I
Sbjct: 931 SLEGPYRNSIKKAHLHGLTYGLSQAHHVLCLCWVFSVLGAYLVVEGLMKLDEVFLVSSAI 990
Query: 2799 LFGSYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSE-EIKDTFQGIISFKNV 2623
+ G+ LG+ A+ I LL+ D + + E G + FK V
Sbjct: 991 VLGAMALGQTSSFAPDYTKAMISAAHIFS-LLERVPQIDSYSDQGEKPKNCSGNVVFKGV 1049
Query: 2622 LFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGND 2443
F+YPTRPD+ VL+ + +V+ GE +ALVG+SG GKST + LL +Y+ G + +DG
Sbjct: 1050 NFNYPTRPDITVLQGLDISVKQGETLALVGSSGCGKSTTVSLLERFYDPFEGEVLVDGLS 1109
Query: 2442 IYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPD--ATEQEIIDALKNANAFDFVCN 2269
+ N+NI+ +R MG+V QEP+LF+ SI +NI +G + T++EI A K AN F+ +
Sbjct: 1110 VRNLNIQWVRAQMGIVSQEPILFDCSIGDNIAYGDNNRKVTQEEIETAAKEANIHSFIES 1169
Query: 2268 FPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQK 2089
D T VG++G QLSGGQKQRIAIAR L+R P+ILLLDEATSALD ESE +VQEAL K
Sbjct: 1170 LTDKYNTRVGDKGTQLSGGQKQRIAIARALIRKPKILLLDEATSALDTESEKVVQEALDK 1229
Query: 2088 ASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQL 1924
A +GRT IV+AHRLSTI+NA+KI V++ G++VE G H+QL+ + GVY +LV QL
Sbjct: 1230 ARMGRTCIVIAHRLSTIQNADKIAVIQNGKVVEQGTHQQLLQLKGVYFSLVTIQL 1284
>gi|833699|gb|AAA75000.1| multidrug resistance protein
gi|1098061|prf||2115220A P-glycoprotein
Length = 1287
Score = 765 bits (1975), Expect = 0.0
Identities = 455/1239 (36%), Positives = 696/1239 (55%), Gaps = 28/1239 (2%)
Frame = -1
Query: 3663 EKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFESD 3484
+K+L G + S+ G P GE + V V ++ + +A + +
Sbjct: 62 DKMLMLFGTIASLAHGAALPLMMLVFGEMTDSFVNV-GQVDTGNFTWESMINASRELQGQ 120
Query: 3483 MNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMSTGH 3304
M + +GF ++Q S +R + +LR++I +FD G
Sbjct: 121 MTTYAYYYSGLGFGVMLCAYIQISFWTLSAGRQIKKIRSNFFHAVLRQEIGWFDINDAGE 180
Query: 3303 LSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGL 3124
L+ L D++ + E +KIA+++ LT V G I+ F W+L S + LS
Sbjct: 181 LNTRLTDDVSKINEGIGDKIAMLLQSLTTLVTGFIIGFIKGWKLTWVMGAISPIMGLSAA 240
Query: 3123 LDSWGKMKN--NEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYA 2950
+ W K+ + K+ + + AG++A + L +TV + GQ +E+ RY + L++ +K
Sbjct: 241 I--WAKVLSAFTNKELKAYAKAGAVAEEVLSSIRTVFAFGGQNKEIHRYEKNLEDAKKIG 298
Query: 2949 LNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEA 2770
+ +A ++S + A + ++G +I +G G V+ + + ++ G++ +G+
Sbjct: 299 IKKAITANVSIGFAFLMIYAAYSLAFWYGTTLIIDGGYTIGSVLTVFFAVIIGAFAVGQT 358
Query: 2769 ILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPTRPDV 2593
+I A+A I +I+ D+ D F E +K D +G I FKNV+F+YP+R D+
Sbjct: 359 SPNIEAFANARGAAYTIFNII-DNQPKIDSFSKEGLKPDKIKGDIEFKNVIFTYPSRKDI 417
Query: 2592 PVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLR 2413
VLK ++ N+ G+ +ALVG+SG GKST +QL+ +Y+ + G I++DG DI ++NI+ LR
Sbjct: 418 QVLKGLNLNIPSGKTVALVGSSGCGKSTTVQLIQRFYDPEDGVITLDGQDIRSLNIRYLR 477
Query: 2412 QAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGER 2233
+ +GVV QEP+LF+T+I +NIR+G+ D T++EI A K ANA+DF+ PD ++T+VGER
Sbjct: 478 EIIGVVSQEPILFDTTIADNIRYGREDVTKEEIERATKEANAYDFIMKLPDKLETLVGER 537
Query: 2232 GAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAH 2053
G QLSGGQKQRIAIAR LVRNP+ILLLDEATSALD ESE +VQ AL KA GRTTIVVAH
Sbjct: 538 GTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQSALDKAREGRTTIVVAH 597
Query: 2052 RLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTN-----------YE 1906
RLSTIRNAN I + G IVE G HK+L+ GVY NLV Q + T+ YE
Sbjct: 598 RLSTIRNANAIAGFDNGVIVEQGSHKELMERGGVYFNLVTLQTVETSKDTEEDLETHIYE 657
Query: 1905 K----MNENEERVTRQSSHSDFPSN--EISHQKIDQEDDYVKKLIAEIKEEGAKKSNICE 1744
K + + V R+SS + S E +++D+E+ KK KEEG + +
Sbjct: 658 KKIPVTHTHSNLVRRKSSRNTIKSKVPETEDKEVDEEE---KK-----KEEGPPPVSFFK 709
Query: 1743 IIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWALSILF 1564
++K + E+ + V+ + I G P + + + +A +M S+S ++L L
Sbjct: 710 VMKLNKPEWPYFVVGVICAMINGATQPAFAIIFSRIIGVFAGPVSQMRSESSMYSLLFLA 769
Query: 1563 LAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNAD 1384
L I F Q + FGK E L+++LR SFK ++ ++DD ++ L+ RL D
Sbjct: 770 LGGVSFITFFLQGFTFGKAGEILTMRLRLGSFKSMLRQEIGWFDDSKNSTGALTTRLATD 829
Query: 1383 SSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQ 1204
+S V A RL + + + A+I+SF Y W+++L +L P++ AG
Sbjct: 830 ASQVQGATGTRLALLAQNVANLGTAIIISFIYGWQLTLLILAIVPVIAAAGLVEMKMFAG 889
Query: 1203 AVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTA 1024
++D EK+ + + +A+ N+RTV +L E + + L+ + K+A + G
Sbjct: 890 HAKKDKKELEKAGKISTDAVLNIRTVVSLTRERKFEAMYEKSLEGPYRNSIKKAHLHGLT 949
Query: 1023 NGFA------CSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYL 862
G + C C+ F G +LV+ + + +LV + + A G ++
Sbjct: 950 YGLSQAHHVLCLCWVFSV-----LGAYLVVEGLMKLDEVFLVSSAIVLGAMALGQTSSFA 1004
Query: 861 PDHRKAIHAAGLIFHLF-TYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDG 685
PD+ KA+ +A IF L P I Y K +G + K V+F Y R D +L G
Sbjct: 1005 PDYTKAMISAAHIFSLLERVPQIDSYSDQGEKPKNCSGNVVFKGVNFNYPTRPDITVLQG 1064
Query: 684 VSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSL 505
+ + + G TLALVG SG GKST +SLLERFY +GEV +D +V ++N+ +R + +
Sbjct: 1065 LDISVKQGETLALVGSSGCGKSTTVSLLERFYDPFEGEVLVDGLSVRNLNIQWVRAQMGI 1124
Query: 504 VSQEPVLFNCSIKENFLFGISH-NASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQ 328
VSQEP+LF+CSI +N +G ++ +Q EI+ A K AN SF+ +T VG++G Q
Sbjct: 1125 VSQEPILFDCSIGDNIAYGDNNRKVTQEEIETAAKEANIHSFIESLTDKYNTRVGDKGTQ 1184
Query: 327 LSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLS 148
LSGGQKQRIAIARA++R PK+LLLDEATSALD++SEKVVQ ALD A + +V+AHRLS
Sbjct: 1185 LSGGQKQRIAIARALIRKPKILLLDEATSALDTESEKVVQEALDKARMGRTCIVIAHRLS 1244
Query: 147 TVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
T+ NAD IAV++NGKV EQGTH++LL+ + +Y+ LV Q
Sbjct: 1245 TIQNADKIAVIQNGKVVEQGTHQQLLQLKGVYFSLVTIQ 1283
Score = 326 bits (836), Expect = 2e-87
Identities = 186/515 (36%), Positives = 298/515 (57%), Gaps = 1/515 (0%)
Frame = -1
Query: 1563 LAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNAD 1384
L F + + Q F+ +A + K+RS F ++ ++D + A L+ RL D
Sbjct: 131 LGFGVMLCAYIQISFWTLSAGRQIKKIRSNFFHAVLRQEIGWFD--INDAGELNTRLTDD 188
Query: 1383 SSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQ 1204
S + + D++ ++ +L ++ I+ F WK++ + P++ L+ +
Sbjct: 189 VSKINEGIGDKIAMLLQSLTTLVTGFIIGFIKGWKLTWVMGAISPIMGLSAAIWAKVLSA 248
Query: 1203 AVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTA 1024
++ A+ K+ A E L ++RTV A +N+ I +L+ + K+A+ +
Sbjct: 249 FTNKELKAYAKAGAVAEEVLSSIRTVFAFGGQNKEIHRYEKNLEDAKKIGIKKAITANVS 308
Query: 1023 NGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKA 844
GFA + Y+++F +GT L++ V + + A G + A
Sbjct: 309 IGFAFLMIYAAYSLAFWYGTTLIIDGGYTIGSVLTVFFAVIIGAFAVGQTSPNIEAFANA 368
Query: 843 IHAAGLIFHLF-TYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLP 667
AA IF++ P I + K + G+IE KNV F Y R D +L G++L +P
Sbjct: 369 RGAAYTIFNIIDNQPKIDSFSKEGLKPDKIKGDIEFKNVIFTYPSRKDIQVLKGLNLNIP 428
Query: 666 AGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPV 487
+G+T+ALVG SG GKST + L++RFY DG + +D +++ +N+ +LRE + +VSQEP+
Sbjct: 429 SGKTVALVGSSGCGKSTTVQLIQRFYDPEDGVITLDGQDIRSLNIRYLREIIGVVSQEPI 488
Query: 486 LFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQ 307
LF+ +I +N +G + ++ EI++A K ANA+ F+ + P L+TLVGERG QLSGGQKQ
Sbjct: 489 LFDTTIADNIRYG-REDVTKEEIERATKEANAYDFIMKLPDKLETLVGERGTQLSGGQKQ 547
Query: 306 RIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADS 127
RIAIARA++RNPK+LLLDEATSALD++SE VVQ+ALD A E +T+VVAHRLST+ NA++
Sbjct: 548 RIAIARALVRNPKILLLDEATSALDTESEAVVQSALDKAREGRTTIVVAHRLSTIRNANA 607
Query: 126 IAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQ 22
IA NG + EQG+H+EL+ + +Y+ LV Q ++
Sbjct: 608 IAGFDNGVIVEQGSHKELMERGGVYFNLVTLQTVE 642
Score = 302 bits (773), Expect = 5e-80
Identities = 202/595 (33%), Positives = 312/595 (51%), Gaps = 6/595 (1%)
Frame = -1
Query: 3690 FQIKCTTRYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLA 3511
F++ + E F +GV+ +++ G QP + V A
Sbjct: 708 FKVMKLNKPEWPYFVVGVICAMINGATQPAFAIIFSRIIGVF-----------------A 750
Query: 3510 HAYKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDIS 3331
S+ + LLF +G F FLQ G+ +R +LR++I
Sbjct: 751 GPVSQMRSESSMYSLLFLALGGVSFITFFLQGFTFGKAGEILTMRLRLGSFKSMLRQEIG 810
Query: 3330 YFDGM--STGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGT 3157
+FD STG L+ L + + + ++AL+ + + I++F W+L
Sbjct: 811 WFDDSKNSTGALTTRLATDASQVQGATGTRLALLAQNVANLGTAIIISFIYGWQLTLLIL 870
Query: 3156 VFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTE 2977
I +GL++ + +K + + AG I+ A+ +TV SL +++ Y +
Sbjct: 871 AIVPVIAAAGLVEMKMFAGHAKKDKKELEKAGKISTDAVLNIRTVVSLTRERKFEAMYEK 930
Query: 2976 ELKNGEKYALNRAFVFSLSRS-ADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYI 2800
L+ + ++ +A + L+ + L +V GA ++ EG ++ V + I
Sbjct: 931 SLEGPYRNSIKKAHLHGLTYGLSQAHHVLCLCWVFSVLGAYLVVEGLMKLDEVFLVSSAI 990
Query: 2799 LFGSYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSE-EIKDTFQGIISFKNV 2623
+ G+ LG+ A+ I LL+ D + + E G + FK V
Sbjct: 991 VLGAMALGQTSSFAPDYTKAMISAAHIFS-LLERVPQIDSYSDQGEKPKNCSGNVVFKGV 1049
Query: 2622 LFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGND 2443
F+YPTRPD+ VL+ + +V+ GE +ALVG+SG GKST + LL +Y+ G + +DG
Sbjct: 1050 NFNYPTRPDITVLQGLDISVKQGETLALVGSSGCGKSTTVSLLERFYDPFEGEVLVDGLS 1109
Query: 2442 IYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPD--ATEQEIIDALKNANAFDFVCN 2269
+ N+NI+ +R MG+V QEP+LF+ SI +NI +G + T++EI A K AN F+ +
Sbjct: 1110 VRNLNIQWVRAQMGIVSQEPILFDCSIGDNIAYGDNNRKVTQEEIETAAKEANIHSFIES 1169
Query: 2268 FPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQK 2089
D T VG++G QLSGGQKQRIAIAR L+R P+ILLLDEATSALD ESE +VQEAL K
Sbjct: 1170 LTDKYNTRVGDKGTQLSGGQKQRIAIARALIRKPKILLLDEATSALDTESEKVVQEALDK 1229
Query: 2088 ASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQL 1924
A +GRT IV+AHRLSTI+NA+KI V++ G++VE G H+QL+ + GVY +LV QL
Sbjct: 1230 ARMGRTCIVIAHRLSTIQNADKIAVIQNGKVVEQGTHQQLLQLKGVYFSLVTIQL 1284
>gi|45382457|ref|NP_990225.1| ABC transporter protein [Gallus gallus]
gi|3355757|emb|CAA08835.1| ABC transporter protein; P-glycoprotein
[Gallus gallus]
Length = 1288
Score = 760 bits (1962), Expect = 0.0
Identities = 455/1235 (36%), Positives = 686/1235 (54%), Gaps = 24/1235 (1%)
Frame = -1
Query: 3663 EKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDL---AHAYKLF 3493
+KLL G + +I G P G+ + V T+ + N T + L A +
Sbjct: 58 DKLLMIFGSLLAIAHGTSLPIAMIIFGDMTDSFV--TSGMTNITGNSSGLNSSADVFNKL 115
Query: 3492 ESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMS 3313
E +M R + + A ++Q S +R ++ ++R++I +FD
Sbjct: 116 EEEMTRYAYYYSAIAAAVLVAAYIQTSFWTLAAGRQVKKIREKFFHAIMRQEIGWFDVND 175
Query: 3312 TGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVL 3133
G L+ L D++ + E +KI +I T F+ G I+ F W+L S + L
Sbjct: 176 AGELNTRLIDDVSKINEGIGDKIGFLIQSETTFLTGFIVGFIRGWKLTLVILAVSPVLGL 235
Query: 3132 SGLLDSWGKMKN--NEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGE 2959
S L W K+ +K+ + AG++A + L +TV + GQ++E++RY + L++ +
Sbjct: 236 SAAL--WAKILTAFTDKEQAAYAKAGAVAEEVLSAVRTVIAFGGQEKEIKRYHKNLEDAK 293
Query: 2958 KYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCL 2779
+ + +A ++S A + A + ++G +I G V+ + + +L G++ +
Sbjct: 294 RIGIRKAITSNISMGAAFLLIYASYALAFWYGTTLILANEYSIGNVLTVFFSVLIGAFSI 353
Query: 2778 GEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPTR 2602
G+ I A+A I +I+ D++ D + K D +G + F+NV F+YP+R
Sbjct: 354 GQTAPSIEAFANARGAAYAIFNII-DNEPEIDSYSDAGHKPDHIKGNLEFQNVFFNYPSR 412
Query: 2601 PDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIK 2422
PDV +LK ++ V G+ +ALVG SG GKST +QL+ +Y+ G I+IDG D+ ++N++
Sbjct: 413 PDVEILKGLNLKVNCGQTVALVGGSGCGKSTTVQLIQRFYDPKEGTITIDGQDLKSLNVR 472
Query: 2421 QLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIV 2242
LR+ +GVV QEPVLF T+I ENIR+G+ D T +EI A K ANA+DF+ P +T+V
Sbjct: 473 YLREIIGVVNQEPVLFATTIAENIRYGREDVTMEEIERATKEANAYDFIMKLPKKFETVV 532
Query: 2241 GERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIV 2062
GERGAQ+SGGQKQRIAIAR LV NP+ILLLDEATSALD ESE +VQ AL KA GRTT+V
Sbjct: 533 GERGAQMSGGQKQRIAIARALVHNPKILLLDEATSALDTESESVVQAALDKAREGRTTVV 592
Query: 2061 VAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTN--YEKMNENE 1888
VAHRLST+RNA+ I V E G I E G+H QLI G+Y LV Q + T + +EN
Sbjct: 593 VAHRLSTVRNADLIAVFESGVITEQGNHSQLIEKKGIYYKLVNMQTIETEDPSSEKSENA 652
Query: 1887 ERVTRQSSHSDFP----------SNEISHQKIDQEDDYVKKLIAEIKEEGAKKSNICEII 1738
V R S S+ S S +K + +D +K +E + +++
Sbjct: 653 VSVKRSGSQSNLDESLKKELRRGSTRRSMKKPGEPNDTDEK--GSSPDEELPPVSFLKLM 710
Query: 1737 KYCRSEYCIL----FIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWALSI 1570
K ++E+ F A++ A+Q + + S+++ E D+ + KS+ ++L
Sbjct: 711 KLNKNEWPYFVAGTFCAIVNGALQPAFSVIFSEIIGIFSET---DQKVLREKSNLYSLLF 767
Query: 1569 LFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLN 1390
L L F Q + FGK E L++KLR M+FK ++ A++DDP ++ L+ RL
Sbjct: 768 LALGIISFFTFFVQGFAFGKAGEILTMKLRFMAFKAMLRQDMAWFDDPKNSTGALTTRLA 827
Query: 1389 ADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFV 1210
D+S V A RL + + + +I+S Y W+++L +L P++ +AG +
Sbjct: 828 NDASQVKGATGVRLALIAQNIANLGTGIIISLVYGWQLTLLLLAVVPIIAVAGMIEMKML 887
Query: 1209 DQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQG 1030
++D I E + + A EA+EN+RTV +L E R L+ HL + K+A I G
Sbjct: 888 AGHAKKDKIELEAAGKIATEAIENIRTVASLTREKRFELMYGEHLLVPYRNSVKKAHIFG 947
Query: 1029 TANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHR 850
+ + FF YA F+FG +LV+ I +LV + A G ++ PD+
Sbjct: 948 FCFSLSQAMMFFTYAGCFRFGAYLVVNGHIEYKTVFLVFSAVVFGAMALGQTSSFAPDYA 1007
Query: 849 KAIHAAGLIFHLFT-YPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLK 673
KA +A +F LF P I Y K G +K+V F Y R + IL G++L
Sbjct: 1008 KAKISAAHLFVLFNRVPPIDSYREDGEKPEKFGGNTRIKDVKFNYPNRPEVKILQGLNLA 1067
Query: 672 LPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQE 493
+ G TLALVG SG GKST++ LLERFY + GE+ D+ + +N+ LR + +VSQE
Sbjct: 1068 VEKGETLALVGSSGCGKSTVVQLLERFYDPLSGEIVFDDIDAKTLNIQWLRSHIGIVSQE 1127
Query: 492 PVLFNCSIKENFLFG-ISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGG 316
P+LF+ +I EN +G S S EI A K A+ SF+ P+ +T VG++G QLSGG
Sbjct: 1128 PILFDFTIAENIAYGDNSREVSHEEIISAAKAASIHSFIDSLPEKYNTRVGDKGTQLSGG 1187
Query: 315 QKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVN 136
QKQRIAIARA++R P++LLLDEATSALD++SEK+VQ ALD A E + +V+AHRLST+ N
Sbjct: 1188 QKQRIAIARALIRKPQILLLDEATSALDTESEKIVQEALDKAREGRTCIVIAHRLSTIQN 1247
Query: 135 ADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
AD IAV++NGKV EQGTH++LL ++ Y+ LV Q
Sbjct: 1248 ADKIAVIQNGKVIEQGTHQQLLAEKGFYYSLVNVQ 1282
Score = 330 bits (846), Expect = 2e-88
Identities = 194/508 (38%), Positives = 293/508 (57%), Gaps = 1/508 (0%)
Frame = -1
Query: 1536 FFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVD 1357
+ Q F+ A + K+R F +M ++D + A L+ RL D S + +
Sbjct: 138 YIQTSFWTLAAGRQVKKIREKFFHAIMRQEIGWFD--VNDAGELNTRLIDDVSKINEGIG 195
Query: 1356 DRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAF 1177
D++G +I + L I+ F WK++L +L P+L L+ + +++ A+
Sbjct: 196 DKIGFLIQSETTFLTGFIVGFIRGWKLTLVILAVSPVLGLSAALWAKILTAFTDKEQAAY 255
Query: 1176 EKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYF 997
K+ A E L VRTV A + + I +L+ + ++A+ + G A +
Sbjct: 256 AKAGAVAEEVLSAVRTVIAFGGQEKEIKRYHKNLEDAKRIGIRKAITSNISMGAAFLLIY 315
Query: 996 FIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFH 817
YA++F +GT L+L E + V ++ + A G + A AA IF+
Sbjct: 316 ASYALAFWYGTTLILANEYSIGNVLTVFFSVLIGAFSIGQTAPSIEAFANARGAAYAIFN 375
Query: 816 LF-TYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVG 640
+ P I Y + K + G +E +NV F Y R D IL G++LK+ G+T+ALVG
Sbjct: 376 IIDNEPEIDSYSDAGHKPDHIKGNLEFQNVFFNYPSRPDVEILKGLNLKVNCGQTVALVG 435
Query: 639 PSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKEN 460
SG GKST + L++RFY +G + ID +++ +N+ +LRE + +V+QEPVLF +I EN
Sbjct: 436 GSGCGKSTTVQLIQRFYDPKEGTITIDGQDLKSLNVRYLREIIGVVNQEPVLFATTIAEN 495
Query: 459 FLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAIL 280
+G + + EI++A K ANA+ F+ + P+ +T+VGERGAQ+SGGQKQRIAIARA++
Sbjct: 496 IRYG-REDVTMEEIERATKEANAYDFIMKLPKKFETVVGERGAQMSGGQKQRIAIARALV 554
Query: 279 RNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKV 100
NPK+LLLDEATSALD++SE VVQ ALD A E +TVVVAHRLSTV NAD IAV ++G +
Sbjct: 555 HNPKILLLDEATSALDTESESVVQAALDKAREGRTTVVVAHRLSTVRNADLIAVFESGVI 614
Query: 99 AEQGTHEELLRKRSIYWRLVQKQGIQVE 16
EQG H +L+ K+ IY++LV Q I+ E
Sbjct: 615 TEQGNHSQLIEKKGIYYKLVNMQTIETE 642
Score = 310 bits (795), Expect = 1e-82
Identities = 208/540 (38%), Positives = 306/540 (56%), Gaps = 10/540 (1%)
Frame = -1
Query: 3501 KLFESDMNRVVLLFFLVGF-AYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYF 3325
K+ N LLF +G ++FTF F+ K G+ +R +LR+D+++F
Sbjct: 754 KVLREKSNLYSLLFLALGIISFFTFFVQGFAFGK-AGEILTMKLRFMAFKAMLRQDMAWF 812
Query: 3324 DGM--STGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVF 3151
D STG L+ L ++ + + ++ALI + + G I++ W+L
Sbjct: 813 DDPKNSTGALTTRLANDASQVKGATGVRLALIAQNIANLGTGIIISLVYGWQLTLLLLAV 872
Query: 3150 SFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEEL 2971
I ++G+++ + +K + AG IA +A+ +TV+SL +++ Y E L
Sbjct: 873 VPIIAVAGMIEMKMLAGHAKKDKIELEAAGKIATEAIENIRTVASLTREKRFELMYGEHL 932
Query: 2970 ----KNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYY 2803
+N K A F FSLS+ A FFT A F FGA ++ G IE V +
Sbjct: 933 LVPYRNSVKKAHIFGFCFSLSQ-AMMFFTYAGCF---RFGAYLVVNGHIEYKTVFLVFSA 988
Query: 2802 ILFGSYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSE-EIKDTFQGIISFKN 2626
++FG+ LG+ A A ++ +L + D + + E + F G K+
Sbjct: 989 VVFGAMALGQTSSFAPDYAKA-KISAAHLFVLFNRVPPIDSYREDGEKPEKFGGNTRIKD 1047
Query: 2625 VLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGN 2446
V F+YP RP+V +L+ ++ V+ GE +ALVG+SG GKSTV+QLL +Y+ SG I D
Sbjct: 1048 VKFNYPNRPEVKILQGLNLAVEKGETLALVGSSGCGKSTVVQLLERFYDPLSGEIVFDDI 1107
Query: 2445 DIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFG--KPDATEQEIIDALKNANAFDFVC 2272
D +NI+ LR +G+V QEP+LF+ +I ENI +G + + +EII A K A+ F+
Sbjct: 1108 DAKTLNIQWLRSHIGIVSQEPILFDFTIAENIAYGDNSREVSHEEIISAAKAASIHSFID 1167
Query: 2271 NFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQ 2092
+ P+ T VG++G QLSGGQKQRIAIAR L+R P+ILLLDEATSALD ESE IVQEAL
Sbjct: 1168 SLPEKYNTRVGDKGTQLSGGQKQRIAIARALIRKPQILLLDEATSALDTESEKIVQEALD 1227
Query: 2091 KASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTN 1912
KA GRT IV+AHRLSTI+NA+KI V++ G+++E G H+QL+A G Y +LV Q S N
Sbjct: 1228 KAREGRTCIVIAHRLSTIQNADKIAVIQNGKVIEQGTHQQLLAEKGFYYSLVNVQSGSCN 1287
>gi|39594783|emb|CAE70651.1| Hypothetical protein CBG17356
[Caenorhabditis briggsae]
Length = 1265
Score = 759 bits (1960), Expect = 0.0
Identities = 447/1239 (36%), Positives = 706/1239 (56%), Gaps = 30/1239 (2%)
Frame = -1
Query: 3657 LLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFESDMN 3478
LL G+VFS +G PF S + VL++ + N T AY F + +
Sbjct: 42 LLLLGGIVFSSASGALLPFNSLIFEGITNVLMQGQSEWQNGTF-------AYDTFSTGIR 94
Query: 3477 RVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMSTGHLS 3298
LL+FL+G F ++ + + + + Y +R+ + +LR+D +FD + G L+
Sbjct: 95 HYCLLYFLLGVFMFLCTYISNACLYTMAERRLYCIRKHLLRSVLRQDAQWFDENTVGGLT 154
Query: 3297 IVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLS-GLL 3121
++ +E+ ++ +KI ++ + F+ G +L FY W+L V + L G +
Sbjct: 155 QKMSSGIEKIKDGIGDKIGVLFSGAATFISGVLLGFYMCWQLTL---VMLITVPLQLGQM 211
Query: 3120 DSWGKMKNNEKQNEH--ISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYAL 2947
K N +NE S+AG +A + + +TV + N Q E+ RY ++L + +
Sbjct: 212 YMSAKHLNRATKNEMSAYSSAGGMANEVIAGIRTVIAFNAQPFEISRYADKLAEARQMGI 271
Query: 2946 NRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEAI 2767
++ V + + L ++GA + G G + + +L G+ LGEA
Sbjct: 272 RKSIVLASCSAVPLVLMFVLMAGAFWYGAILTSFGIATSGTTFGVFWAVLLGTRRLGEAA 331
Query: 2766 LHISRLASAIPLTVPIADILLDSDATADEFFSEEI---KDTFQGIISFKNVLFSYPTRPD 2596
H+ + A + I DI D + ++E + G ++F N+ F+YPTRPD
Sbjct: 332 PHMGAILGA---RLAINDIFKVIDNEPEINCTKETGRRPEKINGKLNFDNIEFTYPTRPD 388
Query: 2595 VPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQL 2416
V +LK +SF V GE +ALVG SG GKST I LL+ +YN +G I +DG I + NI+ L
Sbjct: 389 VKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGTIKLDGVPIEDYNIQWL 448
Query: 2415 RQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGE 2236
R +G+V QEP++F ++ ENIR G T+++I DA + ANA DF+ + DG TI+G
Sbjct: 449 RSTIGIVQQEPIIFLATVSENIRMGDNSITDKDIEDACRQANAHDFIGHLSDGYNTIIGA 508
Query: 2235 RGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVA 2056
QLSGGQKQR+AIAR +VR P+ILLLDEATSALD ESE +VQ AL KAS GRTT+ +A
Sbjct: 509 GAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQAALDKASQGRTTLCIA 568
Query: 2055 HRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYE-------KMN 1897
HRLSTIRNANKI+V ++G IVE G H QLI NG+Y ++V+ Q + E +
Sbjct: 569 HRLSTIRNANKILVFDQGLIVEKGTHDQLIRQNGIYASMVRAQEIERAKEDTVVEDDSLE 628
Query: 1896 ENEERVTRQSSHSDFPSNE-----------------ISHQKIDQEDDYVKKLIAEIKEEG 1768
E + ++R+ S S+ + ++ Q D E + ++ E+ EEG
Sbjct: 629 EETQSISRRLSTSEDEVRKSKSLLRDSARLSQSMLSVTSQVPDWEVEIARE---EMFEEG 685
Query: 1767 AKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSH 1588
A ++++ +I ++ + E + IA++ + I+GI +P S + + ++ +A +++ + +
Sbjct: 686 AMEASMMDIFRFAKPEKWNVIIALIVTLIRGITWPAFSVVYGQLFKVFAEGGEDLPTNAF 745
Query: 1587 FWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATR 1408
+L + LAFT I F GKT E +S +LR FK++M +++D+P H
Sbjct: 746 VSSLWFILLAFTSGITTFISGSLLGKTGETMSSRLRLNVFKNIMQQDASYFDEPKHNVGN 805
Query: 1407 LSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGY 1228
L+ RL DS NV AA+D RL V+ ++++ + ++F++ W M+ L+ LL +A
Sbjct: 806 LTARLATDSQNVQAAIDHRLAEVLNGVISLFAGIAVAFWFGWSMAPIGLLTALLLVIAQS 865
Query: 1227 CNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFK 1048
++ +D + +++R E++ N +TV+AL + + T+ +K R F
Sbjct: 866 SVAQYLKYRGPKDMESAIEASRIVTESISNWKTVQALTKQEYMYGAFTTASKKPRQRAFA 925
Query: 1047 RAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVA 868
+ + Q + A S + + +A+++ FG WL+ P + V+ L+M + A +
Sbjct: 926 KGLWQSLSFALAGSFFLWNFAIAYMFGLWLISNNWTTPFAVFQVIEALNMASMSVMMAAS 985
Query: 867 YLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILD 688
Y P++ +A +AG++F + + + G+ + G+I ++ V F Y R ++IL+
Sbjct: 986 YFPEYVRARISAGIMFTMIRQKSAIDNRGLTGETPLIKGDISMRGVYFAYPNRKRQLILN 1045
Query: 687 GVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVS 508
++ G+T+ALVGPSG GKST I L+ER+Y AV G V+ID+ +V D+++ HLR++++
Sbjct: 1046 NFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDAVCGSVRIDDTDVRDISVKHLRDNIA 1105
Query: 507 LVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQ 328
LV QEP LFN SI+EN +G+ N SQ +I++A K+AN +FV P+G DT VG G +
Sbjct: 1106 LVGQEPTLFNLSIRENITYGL-ENVSQEQIEEAAKLANIHNFVISLPEGYDTSVGASGGR 1164
Query: 327 LSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLS 148
LSGGQKQRIAIARAI+R+PK+LLLDEATSALDS+SEK+VQ ALD A + VV+AHRLS
Sbjct: 1165 LSGGQKQRIAIARAIVRDPKILLLDEATSALDSESEKIVQEALDKARLGRTCVVIAHRLS 1224
Query: 147 TVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
T+ NAD I V +NGK E+GTH+ LL +R +Y+RLV+KQ
Sbjct: 1225 TIQNADKIIVCRNGKAIEEGTHQSLLARRGLYYRLVEKQ 1263
Score = 270 bits (690), Expect = 2e-70
Identities = 163/519 (31%), Positives = 274/519 (52%), Gaps = 5/519 (0%)
Frame = -1
Query: 1563 LAFTRPIFIFFQYYFFGKT----AEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNR 1396
L F +F+F Y AE+ +R + ++ ++D+ +T L+ +
Sbjct: 99 LYFLLGVFMFLCTYISNACLYTMAERRLYCIRKHLLRSVLRQDAQWFDE--NTVGGLTQK 156
Query: 1395 LNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDN 1216
+++ + + D++G + + V++ F+ W+++L +L+ PL Y +
Sbjct: 157 MSSGIEKIKDGIGDKIGVLFSGAATFISGVLLGFYMCWQLTLVMLITVPLQLGQMYMSAK 216
Query: 1215 FVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVI 1036
+++A + + A+ + A E + +RTV A N + I L + R +++++
Sbjct: 217 HLNRATKNEMSAYSSAGGMANEVIAGIRTVIAFNAQPFEISRYADKLAEARQMGIRKSIV 276
Query: 1035 QGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPD 856
+ + F + A +F +G L T+ V + + G A ++
Sbjct: 277 LASCSAVPLVLMFVLMAGAFWYGAILTSFGIATSGTTFGVFWAVLLGTRRLGEAAPHMGA 336
Query: 855 HRKAIHAAGLIFHLFTYPAIMPYDSSQGKRNIK-NGEIELKNVSFEYAQRSDKMILDGVS 679
A A IF + + G+R K NG++ N+ F Y R D IL GVS
Sbjct: 337 ILGARLAINDIFKVIDNEPEINCTKETGRRPEKINGKLNFDNIEFTYPTRPDVKILKGVS 396
Query: 678 LKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVS 499
++ G T+ALVG SG GKST I LL RFY+ G +K+D + D N+ LR ++ +V
Sbjct: 397 FEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGTIKLDGVPIEDYNIQWLRSTIGIVQ 456
Query: 498 QEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSG 319
QEP++F ++ EN G ++ + +I+ A + ANA F+ G +T++G QLSG
Sbjct: 457 QEPIIFLATVSENIRMG-DNSITDKDIEDACRQANAHDFIGHLSDGYNTIIGAGAVQLSG 515
Query: 318 GQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVV 139
GQKQR+AIARAI+R P++LLLDEATSALD++SE++VQ ALD AS+ +T+ +AHRLST+
Sbjct: 516 GQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQAALDKASQGRTTLCIAHRLSTIR 575
Query: 138 NADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQ 22
NA+ I V G + E+GTH++L+R+ IY +V+ Q I+
Sbjct: 576 NANKILVFDQGLIVEKGTHDQLIRQNGIYASMVRAQEIE 614
>gi|126924|sp|P21448|MDR1_CRIGR Multidrug resistance protein 1
(P-glycoprotein 1)
gi|191165|gb|AAA68883.1| p-glycoprotein isoform I
Length = 1276
Score = 758 bits (1957), Expect = 0.0
Identities = 449/1231 (36%), Positives = 680/1231 (54%), Gaps = 20/1231 (1%)
Frame = -1
Query: 3663 EKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKV----TNAINNKTIDPVDLAHAYKL 3496
++L +G + +I+ G+ P G+ + V TNA NN T V+ + +
Sbjct: 46 DRLYMLVGTLAAIIHGVALPLMMLVFGDMTDSFASVGNIPTNATNNAT--QVNASDIFGK 103
Query: 3495 FESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGM 3316
E +M + +G ++Q S + +R+++ ++ ++I +FD
Sbjct: 104 LEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVH 163
Query: 3315 STGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIV 3136
G L+ L D++ + E +KI + + F G I+ F W+L + + V
Sbjct: 164 DVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTL--VILAISPV 221
Query: 3135 LSGLLDSWGKMKNN--EKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNG 2962
L W K+ ++ +K+ + + AG++A + L +TV + GQ++E+ERY L+
Sbjct: 222 LGLSAGIWAKILSSFTDKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEA 281
Query: 2961 EKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYC 2782
++ + +A ++S A + A + ++G +++ G V+ + + +L G++
Sbjct: 282 KRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYSIGQVLTVFFAVLIGAFS 341
Query: 2781 LGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPT 2605
+G+A +I A+A I +I+ D+ + D F K D +G + FKN+ FSYP+
Sbjct: 342 IGQASPNIEAFANARGAAYEIFNII-DNKPSIDSFSKNGYKPDNIKGNLEFKNIHFSYPS 400
Query: 2604 RPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINI 2425
R DV +LK ++ VQ G+ +ALVG SG GKST +QLL Y+ G +SIDG DI IN+
Sbjct: 401 RKDVQILKGLNLKVQSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGVVSIDGQDIRTINV 460
Query: 2424 KQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTI 2245
+ LR+ +GVV QEPVLF T+I ENIR+G+ + T EI A+K ANA+DF+ P T+
Sbjct: 461 RYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTL 520
Query: 2244 VGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTI 2065
VGERGAQLSGGQKQRIAIAR LVRNP+ILLLDEATSALD ESE +VQ AL KA GRTTI
Sbjct: 521 VGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTI 580
Query: 2064 VVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNENEE 1885
V+AHRLST+RNA+ I + G IVE G+H++L+ G+Y LV TQ E NE E
Sbjct: 581 VIAHRLSTVRNADIIAGFDGGVIVEQGNHEELMREKGIYFKLVMTQTAGNEIELGNEVGE 640
Query: 1884 R--------VTRQSSHSDFPSNEISHQKIDQEDDYVKKL-IAEIKEEGAKKSNICEIIKY 1732
++ + S S + + I D +KL E +E + I+K
Sbjct: 641 SKNEIDNLDMSSKDSASSLIRRRSTRRSIRGPHDQDRKLSTKEALDEDVPPISFWRILKL 700
Query: 1731 CRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSK--SHFWALSILFLA 1558
SE+ + + + + G P S + K + + D+ + S+ ++L L L
Sbjct: 701 NSSEWPYFVVGIFCAIVNGALQPAFSIIFSKVVGVFTRNTDDETKRHDSNLFSLLFLILG 760
Query: 1557 FTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSS 1378
I F Q + FGK E L+ +LR M FK ++ +++D+P +T L+ RL D+
Sbjct: 761 VISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDNPKNTTGALTTRLANDAG 820
Query: 1377 NVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAV 1198
V A RL + + + +I+S Y W+++L +L P++ +AG +
Sbjct: 821 QVKGATGARLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQA 880
Query: 1197 EEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANG 1018
+D E S + A EA+EN RTV +L E + + LQ + K+A + G
Sbjct: 881 LKDKKELEGSGKIATEAIENFRTVVSLTREQKFENMYAQSLQIPYRNALKKAHVFGITFS 940
Query: 1017 FACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKA-I 841
F + +F YA F+FG +LV RE + + LV + A G ++ PD+ KA +
Sbjct: 941 FTQAMMYFSYAACFRFGAYLVARELMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKAKV 1000
Query: 840 HAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAG 661
A+ +I + P+I Y + K N G ++ V F Y R D +L G++L++ G
Sbjct: 1001 SASHIIMIIEKVPSIDSYSTGGLKPNTLEGNVKFNEVVFNYPTRPDIPVLQGLNLEVKKG 1060
Query: 660 RTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLF 481
+TLALVG SG GKST++ LLERFY + G V +D + V +N+ LR + +VSQEP+LF
Sbjct: 1061 QTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEVNQLNVQWLRAHLGIVSQEPILF 1120
Query: 480 NCSIKENFLFG-ISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQR 304
+CSI EN +G S SQ EI++A K AN F+ P +T VG++G QLSGGQKQR
Sbjct: 1121 DCSIAENIAYGDNSRVVSQDEIERAAKEANIHQFIESLPDKYNTRVGDKGTQLSGGQKQR 1180
Query: 303 IAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSI 124
IAIARA++R P +LLLDEATSALD++SEKVVQ ALD A E + +V+AHRLST+ NAD I
Sbjct: 1181 IAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLI 1240
Query: 123 AVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
V++NGKV E GTH++LL ++ IY+ +V Q
Sbjct: 1241 VVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQ 1271
>gi|25453370|ref|NP_036755.2| P-glycoprotein/multidrug resistance 1;
ATP-binding cassette, sub-family B (MDR/TAP), member 1
(P-glycoprotein/multidrug resistance 1); ATP-binding
cassette sub-family B (MDR/TAP) member 1
(P-glycoprotein/multidrug resistance 1) [Rattus
norvegicus]
gi|19743730|gb|AAL92458.1| ATP-binding cassette protein B1b [Rattus
norvegicus]
Length = 1275
Score = 756 bits (1951), Expect = 0.0
Identities = 457/1236 (36%), Positives = 690/1236 (54%), Gaps = 27/1236 (2%)
Frame = -1
Query: 3663 EKLLFFLGVVFSILTGMCQPF---------ESYTLGETSQVLVKVTNAINNKTIDPVDLA 3511
+KL LG + +I+ G P +S+T ET ++L VTN + V +
Sbjct: 45 DKLCMALGTLAAIIHGTLLPLLMLVFGYMTDSFTQAET-RILPSVTNQSEINSTQTVSDS 103
Query: 3510 HAYKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDIS 3331
E DM + +G ++Q S+ + +R+++ ++ ++I
Sbjct: 104 S----LEEDMAMYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFFHAIMNQEIG 159
Query: 3330 YFDGMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVF 3151
+FD G L+ L D++ + + +K+ + +T F G I+ F + W+L
Sbjct: 160 WFDVNDAGELNTRLTDDVSKINDGIGDKLGMFFQSITTFSAGFIIGFISGWKLTLVILAV 219
Query: 3150 SFGIVLSGLLDSWGKMKNN--EKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTE 2977
S I LS + W K+ + K+ + + AG++A + L +TV + GQ++E+ERY +
Sbjct: 220 SPLIGLSSAM--WAKVLTSFTNKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNK 277
Query: 2976 ELKNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYIL 2797
L+ ++ + +A ++S Y A + ++G +++ G V+ + + IL
Sbjct: 278 NLEEAKRVGIKKAITANISIGIAYLLVYASYALAFWYGTSLVLSNEYSIGQVLTVFFSIL 337
Query: 2796 FGSYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVL 2620
G++ +G +I A+A I I+ D++ + D F ++ K D+ G + FKNV
Sbjct: 338 LGTFSIGHLAPNIEAFANARGAAYEIFKII-DNEPSIDSFSTKGHKPDSIMGNLEFKNVY 396
Query: 2619 FSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDI 2440
F+YP+R +V +LK ++ V+ G+ +ALVG SG GKST +QLL Y+ G +SIDG DI
Sbjct: 397 FNYPSRSEVKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEGEVSIDGQDI 456
Query: 2439 YNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPD 2260
IN++ LR+ +GVV QEPVLF T+I ENIR+G+ + T EI A+K ANA+DF+ P
Sbjct: 457 RTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPH 516
Query: 2259 GIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASI 2080
T+VGERGAQLSGGQKQRIAIAR LVRNP+ILLLDEATSALD ESE +VQ AL KA
Sbjct: 517 KFNTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKARE 576
Query: 2079 GRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKM 1900
GRTTIV+AHRLST+RNA+ I + G IVE G+H++L+ G+Y LV TQ E
Sbjct: 577 GRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEELMKEKGIYFKLVMTQTRGNEIEPG 636
Query: 1899 NENEE--------RVTRQSSHSDFPSNEIS---HQKIDQEDDYVKKLIAEIKEEGAKKSN 1753
N E +T + S S I H++ DQE K E +E +
Sbjct: 637 NNAYESQSDTGASELTSEKSKSPLIRRSIRRSIHRRQDQERRLSSK---EDVDEDVPMVS 693
Query: 1752 ICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWALS 1573
+I+K SE+ L + VL + I G P+ + + K ++ D D + + S
Sbjct: 694 FWQILKLNISEWPYLVVGVLCAVINGCIQPVFAIVFSKIVGVFSRDDDHETKQRNCNLFS 753
Query: 1572 ILFLAFTRPIFI--FFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSN 1399
+LFL F+ FFQ + FGK E L+ +LR M FK ++ +++DD +T L+
Sbjct: 754 LLFLVMGMISFVTYFFQGFAFGKAGEILTKRLRYMVFKSMLRQDISWFDDHKNTTGSLTT 813
Query: 1398 RLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCND 1219
RL +D+SNV A+ RL V + + +I+S Y W+++L +++ PL+ L G
Sbjct: 814 RLASDASNVKGAMGSRLAVVTQNVANLGTGIILSLVYGWQLTLLLVVIIPLIVLGGIIEM 873
Query: 1218 NFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAV 1039
+ +D E S + A EA+EN RTV +L E + + LQ + K+A
Sbjct: 874 KLLSGQALKDKKELEISGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNALKKAH 933
Query: 1038 IQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLP 859
+ G F + +F YA F+FG +LV RE + + LV + A AG+ ++ P
Sbjct: 934 VFGITFAFTQAMIYFSYAACFRFGAYLVARELMTFENVMLVFSAVVFGAMAAGNTSSFAP 993
Query: 858 DHRKA-IHAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGV 682
D+ KA + A+ +I + P I Y + K N G ++ V F Y R + +L G+
Sbjct: 994 DYAKAKVSASHIIRIIEKIPEIDSYSTEGLKPNWLEGNVKFNGVMFNYPTRPNIPVLQGL 1053
Query: 681 SLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLV 502
S ++ G+TLALVG SG GKST++ LLERFY+ + G V +D + + +N+ LR + +V
Sbjct: 1054 SFEVKKGQTLALVGSSGCGKSTVVQLLERFYNPMAGTVFLDGKEIKQLNVQWLRAHLGIV 1113
Query: 501 SQEPVLFNCSIKENFLFG-ISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQL 325
SQEP+LF+CSI EN +G S S EI +A + AN F+ P+ +T VG++G QL
Sbjct: 1114 SQEPILFDCSITENIAYGDNSRVVSHEEIVRAAREANIHQFIDSLPEKYNTRVGDKGTQL 1173
Query: 324 SGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLST 145
SGGQKQRIAIARA++R P +LLLDEATSALD++SEKVVQ ALD A E + +V+AHRLST
Sbjct: 1174 SGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLST 1233
Query: 144 VVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQ 37
+ NAD I V++NG+V E GTH++LL ++ IY+ +VQ
Sbjct: 1234 IQNADLIVVIQNGQVKEHGTHQQLLAQKGIYFSMVQ 1269
Score = 330 bits (847), Expect = 1e-88
Identities = 194/494 (39%), Positives = 289/494 (58%), Gaps = 3/494 (0%)
Frame = -1
Query: 1488 KLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLA 1309
K+R F +M+ ++D + A L+ RL D S + + D+LG ++
Sbjct: 144 KIRQKFFHAIMNQEIGWFD--VNDAGELNTRLTDDVSKINDGIGDKLGMFFQSITTFSAG 201
Query: 1308 VIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRT 1129
I+ F WK++L +L PL+ L+ + ++ A+ K+ A E L +RT
Sbjct: 202 FIIGFISGWKLTLVILAVSPLIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRT 261
Query: 1128 VRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLR 949
V A + + + +L++ + K+A+ + G A + YA++F +GT LVL
Sbjct: 262 VIAFGGQKKELERYNKNLEEAKRVGIKKAITANISIGIAYLLVYASYALAFWYGTSLVLS 321
Query: 948 EEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFHLF-TYPAIMPYDSSQG 772
E V ++ + G + A AA IF + P+I + +
Sbjct: 322 NEYSIGQVLTVFFSILLGTFSIGHLAPNIEAFANARGAAYEIFKIIDNEPSIDSFSTKGH 381
Query: 771 KRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERF 592
K + G +E KNV F Y RS+ IL G++LK+ +G+T+ALVG SG GKST + LL+R
Sbjct: 382 KPDSIMGNLEFKNVYFNYPSRSEVKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRL 441
Query: 591 YHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQ 412
Y ++GEV ID +++ +N+ +LRE + +VSQEPVLF +I EN +G N + EI++
Sbjct: 442 YDPIEGEVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYG-RENVTMDEIEK 500
Query: 411 ALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALD 232
A+K ANA+ F+ + P +TLVGERGAQLSGGQKQRIAIARA++RNPK+LLLDEATSALD
Sbjct: 501 AVKEANAYDFIMKLPHKFNTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALD 560
Query: 231 SDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIY 52
++SE VVQ ALD A E +T+V+AHRLSTV NAD IA G + EQG HEEL++++ IY
Sbjct: 561 TESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEELMKEKGIY 620
Query: 51 WRLV--QKQGIQVE 16
++LV Q +G ++E
Sbjct: 621 FKLVMTQTRGNEIE 634
>gi|17569145|ref|NP_509902.1| P-GlycoProtein related (pgp-4)
[Caenorhabditis elegans]
gi|7503247|pir||T22090 hypothetical protein F42E11.1 - Caenorhabditis
elegans
gi|3877005|emb|CAA91463.1| Hypothetical protein F42E11.1
[Caenorhabditis elegans]
Length = 1266
Score = 755 bits (1950), Expect = 0.0
Identities = 442/1236 (35%), Positives = 698/1236 (55%), Gaps = 27/1236 (2%)
Frame = -1
Query: 3657 LLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFESDMN 3478
LL G+V S G PF S + VL+K N T D Y F S +
Sbjct: 42 LLLLGGLVLSAANGALLPFNSLIFEGITNVLMKGEAQWQNGTFD-------YDTFSSGIQ 94
Query: 3477 RVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMSTGHLS 3298
LL+FL+G FT + + + + + Y +R+ + +LR+D +FD + G L+
Sbjct: 95 HYCLLYFLLGVLMFTCTYFSNACLFTMAERRLYCIRKHLLQSVLRQDAKWFDENTVGGLT 154
Query: 3297 IVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLLD 3118
++ +E+ ++ +KI ++++ + F+ G L FY W+L V + + L +
Sbjct: 155 QKMSSGIEKIKDGIGDKIGVLVSGIATFISGVALGFYMCWQLTLVMLV-TVPLQLGSMYL 213
Query: 3117 SWGKMKNNEKQNEH--ISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALN 2944
S K N +NE S+AG +A + + +TV + N Q E+ERY +L K +
Sbjct: 214 S-AKHLNRATKNEMSAYSSAGGMANEVIAGIRTVIAFNAQPFEIERYGAQLAKARKMGIR 272
Query: 2943 RAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEAIL 2764
+A V +L + F L ++GA + G G + + ++ G+ LGEA
Sbjct: 273 KAIVLALCSAMPLFLMFVLMAGAFWYGAILTSYGVATSGTTFGVFWAVILGTRRLGEAAP 332
Query: 2763 HISRLASAIPLTVPIADI--LLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPTRPDV 2593
H+ + A + + DI ++D + + E + D G + F N+ F+YPTRPDV
Sbjct: 333 HMGAITGA---RLAVNDIFKVIDHEPEINCTKQEGRRPDKVNGKLVFDNIQFTYPTRPDV 389
Query: 2592 PVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLR 2413
+LK +SF V GE IALVG SG GKST I LL+ +YN +G I +DG I + NI+ LR
Sbjct: 390 KILKGVSFEVNPGETIALVGHSGCGKSTSIGLLMRFYNQCAGSIKLDGIPIEDYNIQWLR 449
Query: 2412 QAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGER 2233
+G+V QEP++F ++ EN+R G T+++I +A + ANA DF+ +G T++G
Sbjct: 450 STIGIVQQEPIIFLATVAENVRMGDDSITDKDIENACRQANAHDFIGKLSEGYNTVIGAG 509
Query: 2232 GAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAH 2053
QLSGGQKQR+AIAR +VR P+ILLLDEATSALD ESE +VQ AL KAS GRTT+ +AH
Sbjct: 510 AVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCIAH 569
Query: 2052 RLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNENEERVTR 1873
RLSTIRNA+KI+V ++G I E G H QLI NG+Y N+V+ Q + + ++++ +
Sbjct: 570 RLSTIRNASKILVFDQGLIPERGIHDQLIRQNGIYANMVRAQEIEKAKDDTTQDDDELVE 629
Query: 1872 QSSHSDFPSNEISHQKIDQE----------------------DDYVKKLIAEIKEEGAKK 1759
+ ++S S +++ + D ++ E+ EEGA +
Sbjct: 630 EDNYSISRRLSTSEEELRKSKSLLRDSTRFSQSMLSVTSQVPDWEMESAREEMIEEGAME 689
Query: 1758 SNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWA 1579
+++ +I ++ + E + IA++ + I+GI +P S + + ++ +A +++ + +
Sbjct: 690 ASMMDIFRFAKPEKMNIVIALIFTLIRGITWPAFSVVYGQLFKVFAEGGEDLPVNALISS 749
Query: 1578 LSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSN 1399
L + LA T + F GKT E +S +LR FK++M ++DDP H L++
Sbjct: 750 LWFVLLAVTSAVTTFISGSLLGKTGETMSSRLRMDVFKNIMQQDATYFDDPKHNVGNLTS 809
Query: 1398 RLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCND 1219
RL DS NV AA+D RL V+ +V++ + ++F++ W M+ L+ LL +A
Sbjct: 810 RLATDSQNVQAAIDHRLAEVLNGVVSLFTGIAVAFWFGWSMAPIGLITALLLVIAQSAVA 869
Query: 1218 NFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAV 1039
++ +D + +++R E++ N +TV+AL + + T+ + R F + +
Sbjct: 870 QYLKYRGPKDMESAIEASRIVTESISNWKTVQALTKQEYMFHAFTAASKNPRKRAFTKGL 929
Query: 1038 IQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLP 859
Q + A S + + +A+++ FG WL+ P + V+ L+M + A +Y P
Sbjct: 930 WQSLSFALAGSFFLWNFAIAYMFGLWLISNNWTTPFAVFQVIEALNMASMSVMMAASYFP 989
Query: 858 DHRKAIHAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVS 679
++ +A +AG++F + A + G+ G+I +K V F Y R+ ++IL+ +
Sbjct: 990 EYVRARISAGIMFTMIRQKAKIDNRGLTGETPDIRGDISMKGVYFAYPNRNRQLILNNFN 1049
Query: 678 LKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVS 499
+ G T+ALVGPSG GKST I L+ER+Y A+ G VKID+ ++ D+++ HLR +++LV
Sbjct: 1050 MSAQFGETVALVGPSGCGKSTSIQLIERYYDAICGAVKIDDHDIRDISVKHLRHNIALVG 1109
Query: 498 QEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSG 319
QEP LFN +I+EN +G+ N SQ ++++A +AN SFV P+G DT VG G +LSG
Sbjct: 1110 QEPTLFNLTIRENITYGL-ENVSQEQVEKAATLANIHSFVENLPEGYDTSVGASGGRLSG 1168
Query: 318 GQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVV 139
GQKQRIAIARAI+RNPK+LLLDEATSALD++SEK+VQ ALD A + VV+AHRLST+
Sbjct: 1169 GQKQRIAIARAIVRNPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRLSTIQ 1228
Query: 138 NADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
NAD I V +NGK E+GTH+ LL +R +Y+RLV+KQ
Sbjct: 1229 NADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 1264
Score = 281 bits (718), Expect = 1e-73
Identities = 180/616 (29%), Positives = 313/616 (50%), Gaps = 12/616 (1%)
Frame = -1
Query: 1833 HQKIDQEDDYVKKLIAEIKEEGAKKSNICEIIKYCR-SEYCILFIAVLGSAIQGIYYPLS 1657
H ++ D KK K ++ +++ + ++ ++Y +L ++ SA G P +
Sbjct: 7 HVELGSRPDKKKK-----KSRSSQGNSLSNLFRHSGCADYLLLLGGLVLSAANGALLPFN 61
Query: 1656 S-------QLMIKS---YEAYAFDKDEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKT 1507
S +++K ++ FD D S + L L +F
Sbjct: 62 SLIFEGITNVLMKGEAQWQNGTFDYDTFSSGIQHYCLLYFLLGVLMFTCTYFSNACLFTM 121
Query: 1506 AEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTL 1327
AE+ +R + ++ ++D+ +T L+ ++++ + + D++G ++ +
Sbjct: 122 AERRLYCIRKHLLQSVLRQDAKWFDE--NTVGGLTQKMSSGIEKIKDGIGDKIGVLVSGI 179
Query: 1326 VAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEA 1147
+ V + F+ W+++L +L+ PL + Y + +++A + + A+ + A E
Sbjct: 180 ATFISGVALGFYMCWQLTLVMLVTVPLQLGSMYLSAKHLNRATKNEMSAYSSAGGMANEV 239
Query: 1146 LENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFG 967
+ +RTV A N + I + L K R ++A++ + F + A +F +G
Sbjct: 240 IAGIRTVIAFNAQPFEIERYGAQLAKARKMGIRKAIVLALCSAMPLFLMFVLMAGAFWYG 299
Query: 966 TWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFHLFTYPAIMPY 787
L T+ V + + G A ++ A A IF + + +
Sbjct: 300 AILTSYGVATSGTTFGVFWAVILGTRRLGEAAPHMGAITGARLAVNDIFKVIDHEPEINC 359
Query: 786 DSSQGKRNIK-NGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTII 610
+G+R K NG++ N+ F Y R D IL GVS ++ G T+ALVG SG GKST I
Sbjct: 360 TKQEGRRPDKVNGKLVFDNIQFTYPTRPDVKILKGVSFEVNPGETIALVGHSGCGKSTSI 419
Query: 609 SLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNAS 430
LL RFY+ G +K+D + D N+ LR ++ +V QEP++F ++ EN G + +
Sbjct: 420 GLLMRFYNQCAGSIKLDGIPIEDYNIQWLRSTIGIVQQEPIIFLATVAENVRMG-DDSIT 478
Query: 429 QLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDE 250
+I+ A + ANA F+ + +G +T++G QLSGGQKQR+AIARAI+R P++LLLDE
Sbjct: 479 DKDIENACRQANAHDFIGKLSEGYNTVIGAGAVQLSGGQKQRVAIARAIVRKPQILLLDE 538
Query: 249 ATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELL 70
ATSALD++SE++VQ ALD ASE +T+ +AHRLST+ NA I V G + E+G H++L+
Sbjct: 539 ATSALDTESERMVQTALDKASEGRTTLCIAHRLSTIRNASKILVFDQGLIPERGIHDQLI 598
Query: 69 RKRSIYWRLVQKQGIQ 22
R+ IY +V+ Q I+
Sbjct: 599 RQNGIYANMVRAQEIE 614
>gi|72477|pir||DVHY1C multidrug resistance protein 1 - Chinese hamster
gi|191155|gb|AAA37004.1| p-glycoprotein
Length = 1276
Score = 755 bits (1949), Expect = 0.0
Identities = 448/1231 (36%), Positives = 678/1231 (54%), Gaps = 20/1231 (1%)
Frame = -1
Query: 3663 EKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKV----TNAINNKTIDPVDLAHAYKL 3496
++L +G + +I+ G+ P G+ + V TNA NN T V+ + +
Sbjct: 46 DRLYMLVGTLAAIIHGVALPLMMLVFGDMTDSFASVGNIPTNATNNAT--QVNASDIFGK 103
Query: 3495 FESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGM 3316
E +M + +G ++Q S + +R+++ ++ ++I +FD
Sbjct: 104 LEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVH 163
Query: 3315 STGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIV 3136
G L+ L D++ + E +KI + + F G I+ F W+L + + V
Sbjct: 164 DVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTL--VILAISPV 221
Query: 3135 LSGLLDSWGKMKNN--EKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNG 2962
L W K+ ++ +K+ + + AG++A + L +TV + GQ++E+ERY L+
Sbjct: 222 LGLSAGIWAKILSSFTDKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEA 281
Query: 2961 EKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYC 2782
++ + +A ++S A + A + ++G +++ G V+ + + +L +
Sbjct: 282 KRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYSIGQVLTVFFAVLIAPFS 341
Query: 2781 LGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPT 2605
+G+A +I A+A I +I+ D+ + D F K D +G + FKN+ FSYP+
Sbjct: 342 IGQASPNIEAFANARGAAYEIFNII-DNKPSIDSFSKNGYKPDNIKGNLEFKNIHFSYPS 400
Query: 2604 RPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINI 2425
R DV +LK ++ VQ G+ +ALVG SG GKST +QLL Y+ G +SIDG DI IN+
Sbjct: 401 RKDVQILKGLNLKVQSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGVVSIDGQDIRTINV 460
Query: 2424 KQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTI 2245
+ LR+ +GVV QEPVLF T+I ENIR+G+ + T EI A+K ANA+DF+ P T+
Sbjct: 461 RYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTL 520
Query: 2244 VGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTI 2065
VGERGAQLSGGQKQRIAIAR LVRNP+ILLLDEATSALD ESE +VQ AL KA GRTTI
Sbjct: 521 VGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTI 580
Query: 2064 VVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNENEE 1885
V+AHRLST+RNA+ I + G IVE G+H++L+ G+Y LV TQ E NE E
Sbjct: 581 VIAHRLSTVRNADIIAGFDGGVIVEQGNHEELMREKGIYFKLVMTQTAGNEIELGNEVGE 640
Query: 1884 R--------VTRQSSHSDFPSNEISHQKIDQEDDYVKKL-IAEIKEEGAKKSNICEIIKY 1732
++ + S S + + I D +KL E +E + I+K
Sbjct: 641 SKNEIDNLDMSSKDSASSLIRRRSTRRSIRGPHDQDRKLSTKEALDEDVPPISFWRILKL 700
Query: 1731 CRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSK--SHFWALSILFLA 1558
SE+ + + + + G P S + K + + D+ + S+ ++L L L
Sbjct: 701 NSSEWPYFVVGIFCAIVNGALQPAFSIIFSKVVGVFTRNTDDETKRHDSNLFSLLFLILG 760
Query: 1557 FTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSS 1378
I F Q + FGK E L+ +LR M FK ++ +++D+P +T L+ RL D+
Sbjct: 761 VISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDNPKNTTGALTTRLANDAG 820
Query: 1377 NVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAV 1198
V A RL + + + +I+S Y W+++L +L P++ +AG +
Sbjct: 821 QVKGATGARLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQA 880
Query: 1197 EEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANG 1018
+D E S + A EA+EN RTV +L E + + LQ + K+A + G
Sbjct: 881 LKDKKELEGSGKIATEAIENFRTVVSLTREQKFENMYAQSLQIPYRNALKKAHVFGITFS 940
Query: 1017 FACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKA-I 841
F + +F YA F+FG +LV RE + + LV + A G ++ PD+ KA +
Sbjct: 941 FTQAMMYFSYAACFRFGAYLVARELMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKAKV 1000
Query: 840 HAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAG 661
A+ +I + P+I Y + K N G ++ V F Y R D +L G++L++ G
Sbjct: 1001 SASHIIMIIEKVPSIDSYSTGGLKPNTLEGNVKFNEVVFNYPTRPDIPVLQGLNLEVKKG 1060
Query: 660 RTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLF 481
+TLALVG SG GKST++ LLERFY + G V +D + V +N+ LR + +VSQEP+LF
Sbjct: 1061 QTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEVNQLNVQWLRAHLGIVSQEPILF 1120
Query: 480 NCSIKENFLFG-ISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQR 304
+CSI EN +G S SQ EI++A K AN F+ P +T VG++G QLSGGQKQR
Sbjct: 1121 DCSIAENIAYGDNSRVVSQDEIERAAKEANIHQFIESLPDKYNTRVGDKGTQLSGGQKQR 1180
Query: 303 IAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSI 124
IAIARA++R P +LLLDEATSALD++SEKVVQ ALD A E + +V+AHRLST+ NAD I
Sbjct: 1181 IAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLI 1240
Query: 123 AVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
V++NGKV E GTH++LL ++ IY+ +V Q
Sbjct: 1241 VVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQ 1271
>gi|50732589|ref|XP_418707.1| PREDICTED: similar to ATP-binding
cassette, sub-family B (MDR/TAP), member 1A; multiple
drug resistant 1a [Gallus gallus]
Length = 1734
Score = 754 bits (1947), Expect = 0.0
Identities = 454/1255 (36%), Positives = 686/1255 (54%), Gaps = 50/1255 (3%)
Frame = -1
Query: 3657 LLFFLGVVFSILTGMCQPFESYTLGETSQVLV--------KVTNAINNKTIDP---VDLA 3511
LL +G++ + G P G+ + V ++NN + P VD+
Sbjct: 124 LLMVVGLIAAAANGTGLPLMIIIFGDMTNAFVLSGVNSSTSEGASVNNSSCQPAPGVDI- 182
Query: 3510 HAYKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDIS 3331
E+DM + + +GFA +Q +RR++ +L ++++
Sbjct: 183 ------EADMTKFAYYYVGIGFAVLILSTIQVWTFLIAATRQTSRIRRKFFFAVLHQEMA 236
Query: 3330 YFDGMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVF 3151
+FD G L+ L D++ E +KI + + + F+ G + F W+L +
Sbjct: 237 WFDSTQIGTLNTRLTDDINTIHEGIGDKICIFVQFFSTFLAGITIGFAHGWKLTL--VIL 294
Query: 3150 SFGIVLSGLLDSWGKMKNN--EKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTE 2977
S +L+ W + + K+ + AG++A + L +TV + NGQQ+ + +Y
Sbjct: 295 SVSPLLAASAAVWSTLLASLTAKELSAYAKAGAVAEEVLTAIRTVVAFNGQQKALAKYDT 354
Query: 2976 ELKNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEG--TIEPGVVVRILYY 2803
L+ + ++ + S F + ++G + E + G V+ + +
Sbjct: 355 NLEAARHVGVKKSITTNTSLGVSQFLIFGSYALAFWYGTKLTVEEPENYDIGRVLIVFFS 414
Query: 2802 ILFGSYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKN 2626
+L G++ LG+A ++ +A+A + I+ + D E K D +G I F+N
Sbjct: 415 VLIGAFSLGQAAPNLESVANARGAAYEVYQII-NKKRLIDSSSKEGYKPDKLKGEIEFRN 473
Query: 2625 VLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGN 2446
+ FSYP+RPD+ +LK ++ VQ G+ IALVGASG GKST +QLL +Y+ D G +++DG
Sbjct: 474 IHFSYPSRPDITILKGLNLKVQTGKTIALVGASGCGKSTTVQLLQRFYDPDQGEVTLDGR 533
Query: 2445 DIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNF 2266
DI +N+K LR+ +G+V QEPVLF T+I ENIR+G+ D ++ EI A K ANAFDF+
Sbjct: 534 DIRTLNVKWLRENIGIVSQEPVLFATTIAENIRYGREDISDAEIEQAAKEANAFDFISRL 593
Query: 2265 PDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKA 2086
PD T+VGERGAQLSGGQKQRIAIAR L RNP+ILLLDEATSALD +SE +VQ AL KA
Sbjct: 594 PDKFNTMVGERGAQLSGGQKQRIAIARALARNPKILLLDEATSALDTQSESVVQAALDKA 653
Query: 2085 SIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYE 1906
GRTTIV+AHRLSTIR A+ I EKG +VE G H +L+ GVY +LV Q S N +
Sbjct: 654 RTGRTTIVIAHRLSTIRTADTIAAFEKGIVVEQGTHSELMLQKGVYYSLVMQQSGSNNVQ 713
Query: 1905 KMNENEERVTRQSSHSDFPSNEISHQKIDQEDDYVKKLIA-------------------- 1786
+EE ++ + S +K++ +D + + +I
Sbjct: 714 DDGTSEEDEETEAEEYEENDKSSSVEKLNLKDHFEEPVITGRGSIRRRSSRYKSKRSSSK 773
Query: 1785 ---------EIKEEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSY 1633
E++EE I+ + E+ + + V+ +A+ G +P + + K
Sbjct: 774 KKSSKKKKKELEEENLPAVPYTRILALNKPEWLYVLLGVIAAAVSGGVHPAFAVIFGKII 833
Query: 1632 EAYAFDKDEMLSKSHFWALSILFL---AFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKH 1462
A+ ++D + LS++FL T +I Q + FGK+ E L+++LRS+SFK
Sbjct: 834 GAFQ-ERDPERRNKNTLVLSLMFLLLGVITLATYI-IQGFMFGKSGEILTMRLRSLSFKA 891
Query: 1461 LMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSW 1282
L+ +YDD + L RL D+S V A RLG + MT+ +L A+I++F Y W
Sbjct: 892 LLQQEIGWYDDQKNAVGVLLTRLATDASQVKGATGSRLGLMTMTVFTLLTAIIIAFVYGW 951
Query: 1281 KMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENR 1102
+++L +L P + A N + V +D A E++ R + E++EN+RTV +L E
Sbjct: 952 QLTLLILACIPFVIAANAANVSSVSGHAAKDQKALEEAGRVSTESVENIRTVASLTREEA 1011
Query: 1101 VILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTY 922
+ L K+A + G G A S +F+ A F+FG WL+ R + +
Sbjct: 1012 FYEKYINSLNGPYRDSLKKAPLYGFTYGIAQSANYFVNAAVFRFGAWLIARCLTNFENVF 1071
Query: 921 LVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFHLF-TYPAIMPYDSSQGKRNIKNGEI 745
+V ++ A G + + PD+ KA +A IFHL P I Y K + G I
Sbjct: 1072 IVFSSVIFAAMNVGQSASLAPDYGKAKVSAQRIFHLLDRKPQIDSYSEEGEKLSNFEGNI 1131
Query: 744 ELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVK 565
E +N+ F Y R + +L G+++K+ G+TLALVG SG GKST I LLERFY V+G+V
Sbjct: 1132 EFRNIHFVYPTRPEVQVLQGLNVKVNKGQTLALVGSSGCGKSTSIQLLERFYDPVEGQVL 1191
Query: 564 IDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHN-ASQLEIDQALKVANAF 388
D + ++L LR + LVSQEP+LF+CSI EN +G ++ SQ EI++A K AN
Sbjct: 1192 ADGFDTKSLHLQWLRSRLGLVSQEPILFDCSIAENIQYGDNNRLVSQEEIEEAAKAANIH 1251
Query: 387 SFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQ 208
+F+ + P+ +T VGE+G QLSGGQKQRIAIARA++RNP VLLLDEATSALD++SEK+VQ
Sbjct: 1252 AFIDKLPEKYNTRVGEKGTQLSGGQKQRIAIARALVRNPAVLLLDEATSALDTESEKIVQ 1311
Query: 207 NALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRL 43
ALD A + + +V+AHRL+T+ NAD IAV++NG+V EQGTH +LL K Y+ L
Sbjct: 1312 KALDNARQGRTCIVIAHRLTTIQNADIIAVIQNGRVVEQGTHSQLLAKEGHYYAL 1366
Score = 329 bits (843), Expect = 4e-88
Identities = 216/666 (32%), Positives = 352/666 (52%), Gaps = 30/666 (4%)
Frame = -1
Query: 1938 VQTQLMSTNYEKMNENEERVTRQSSHS-DFPSNEISHQKIDQEDDYVKKLIAEIKEEGAK 1762
++ ++M+ N + +N E+ ++ S ++ + I H+K +E D +K + K++ K
Sbjct: 48 IKQEIMTVN-QSLNFTEKDLSESEPASMEYDNPSIQHEKNLEESDRLKAKKKKKKDKSEK 106
Query: 1761 KS-NICEIIKYCR-SEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAF---------- 1618
K + E+ +Y + ++ + ++ +A G PL + A+
Sbjct: 107 KVVGVIELFRYADWVDILLMVVGLIAAAANGTGLPLMIIIFGDMTNAFVLSGVNSSTSEG 166
Query: 1617 --------------DKDEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLR 1480
D + ++K ++ + I F I Q + F A + + ++R
Sbjct: 167 ASVNNSSCQPAPGVDIEADMTKFAYYYVGIGFAVL---ILSTIQVWTFLIAATRQTSRIR 223
Query: 1479 SMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIM 1300
F ++ A++D L+ RL D + + + D++ + L + +
Sbjct: 224 RKFFFAVLHQEMAWFDST--QIGTLNTRLTDDINTIHEGIGDKICIFVQFFSTFLAGITI 281
Query: 1299 SFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRA 1120
F + WK++L +L PLL + + ++ A+ K+ A E L +RTV A
Sbjct: 282 GFAHGWKLTLVILSVSPLLAASAAVWSTLLASLTAKELSAYAKAGAVAEEVLTAIRTVVA 341
Query: 1119 LNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLRE-E 943
N + + + ++L+ R+ K+++ T+ G + F YA++F +GT L + E E
Sbjct: 342 FNGQQKALAKYDTNLEAARHVGVKKSITTNTSLGVSQFLIFGSYALAFWYGTKLTVEEPE 401
Query: 942 ILPMDTYLVLMTLSMTASYA-GSAVAYLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGKR 766
+ L++ + +++ G A L A AA ++ + ++ S +G +
Sbjct: 402 NYDIGRVLIVFFSVLIGAFSLGQAAPNLESVANARGAAYEVYQIINKKRLIDSSSKEGYK 461
Query: 765 NIK-NGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFY 589
K GEIE +N+ F Y R D IL G++LK+ G+T+ALVG SG GKST + LL+RFY
Sbjct: 462 PDKLKGEIEFRNIHFSYPSRPDITILKGLNLKVQTGKTIALVGASGCGKSTTVQLLQRFY 521
Query: 588 HAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQA 409
GEV +D ++ +N+ LRE++ +VSQEPVLF +I EN +G + S EI+QA
Sbjct: 522 DPDQGEVTLDGRDIRTLNVKWLRENIGIVSQEPVLFATTIAENIRYG-REDISDAEIEQA 580
Query: 408 LKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDS 229
K ANAF F+S+ P +T+VGERGAQLSGGQKQRIAIARA+ RNPK+LLLDEATSALD+
Sbjct: 581 AKEANAFDFISRLPDKFNTMVGERGAQLSGGQKQRIAIARALARNPKILLLDEATSALDT 640
Query: 228 DSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYW 49
SE VVQ ALD A +T+V+AHRLST+ AD+IA + G V EQGTH EL+ ++ +Y+
Sbjct: 641 QSESVVQAALDKARTGRTTIVIAHRLSTIRTADTIAAFEKGIVVEQGTHSELMLQKGVYY 700
Query: 48 RLVQKQ 31
LV +Q
Sbjct: 701 SLVMQQ 706
>gi|6755046|ref|NP_035205.1| ATP-binding cassette, sub-family B
(MDR/TAP), member 1B; P glycoprotein 1 [Mus musculus]
gi|126927|sp|P06795|MDR1_MOUSE Multidrug resistance protein 1
(P-glycoprotein 1)
gi|72474|pir||DVMS1 multidrug resistance protein 1 - mouse
gi|387426|gb|AAA79005.1| multidrug resistance protein
Length = 1276
Score = 749 bits (1935), Expect = 0.0
Identities = 446/1229 (36%), Positives = 685/1229 (55%), Gaps = 20/1229 (1%)
Frame = -1
Query: 3663 EKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVK----VTNAINNKTIDPVDLAHAYKL 3496
+KL LG + +I+ G P G + K + +I N++ L +
Sbjct: 46 DKLCMILGTLAAIIHGTLLPLLMLVFGNMTDSFTKAEASILPSITNQSGPNSTLIISNSS 105
Query: 3495 FESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGM 3316
E +M + +G ++Q S+ + +R+++ ++ ++I +FD
Sbjct: 106 LEEEMAIYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVH 165
Query: 3315 STGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIV 3136
G L+ L D++ + + +KI + +T F+ G I+ F + W+L S I
Sbjct: 166 DVGELNTRLTDDVSKINDGIGDKIGMFFQSITTFLAGFIIGFISGWKLTLVILAVSPLIG 225
Query: 3135 LSGLLDSWGKMKNN--EKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNG 2962
LS L W K+ + K+ + + AG++A + L +TV + GQQ+E+ERY + L+
Sbjct: 226 LSSAL--WAKVLTSFTNKELQAYAKAGAVAEEVLAAIRTVIAFGGQQKELERYNKNLEEA 283
Query: 2961 EKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYC 2782
+ + +A S+S Y A + ++G +++ G V+ + + IL G++
Sbjct: 284 KNVGIKKAITASISIGIAYLLVYASYALAFWYGTSLVLSNEYSIGEVLTVFFSILLGTFS 343
Query: 2781 LGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPT 2605
+G +I A+A I I+ D++ + D F ++ K D+ G + FKNV F+YP+
Sbjct: 344 IGHLAPNIEAFANARGAAFEIFKII-DNEPSIDSFSTKGYKPDSIMGNLEFKNVHFNYPS 402
Query: 2604 RPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINI 2425
R +V +LK ++ V+ G+ +ALVG SG GKST +QL+ Y+ G +SIDG DI IN+
Sbjct: 403 RSEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLEGVVSIDGQDIRTINV 462
Query: 2424 KQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTI 2245
+ LR+ +GVV QEPVLF T+I ENIR+G+ D T EI A+K ANA+DF+ P T+
Sbjct: 463 RYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPHQFDTL 522
Query: 2244 VGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTI 2065
VGERGAQLSGGQKQRIAIAR LVRNP+ILLLDEATSALD ESE +VQ AL KA GRTTI
Sbjct: 523 VGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTI 582
Query: 2064 VVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNE--- 1894
V+AHRLST+RNA+ I + G IVE G+H +L+ G+Y LV TQ E N
Sbjct: 583 VIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTRGNEIEPGNNAYG 642
Query: 1893 -----NEERVTRQSSHSDFPSNEISHQKIDQEDDYVKKL-IAEIKEEGAKKSNICEIIKY 1732
+ +T + S S I ++ + ++ D ++L + E +E + I+
Sbjct: 643 SQSDTDASELTSEESKSPLIRRSI-YRSVHRKQDQERRLSMKEAVDEDVPLVSFWRILNL 701
Query: 1731 CRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWALSILFLAFT 1552
SE+ L + VL + I G P+ + + + ++ D D + + S+ FL
Sbjct: 702 NLSEWPYLLVGVLCAVINGCIQPVFAIVFSRIVGVFSRDDDHETKRQNCNLFSLFFLVMG 761
Query: 1551 RPIFI--FFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSS 1378
F+ FFQ + FGK E L+ ++R M FK ++ +++DD ++ L+ RL +D+S
Sbjct: 762 LISFVTYFFQGFTFGKAGEILTKRVRYMVFKSMLRQDISWFDDHKNSTGSLTTRLASDAS 821
Query: 1377 NVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAV 1198
+V A+ RL V + + VI+S Y W+++L +++ PL+ L G +
Sbjct: 822 SVKGAMGARLAVVTQNVANLGTGVILSLVYGWQLTLLLVVIIPLIVLGGIIEMKLLSGQA 881
Query: 1197 EEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANG 1018
+D E S + A EA+EN RT+ +L E + + LQ + K+A + G
Sbjct: 882 LKDKKQLEISGKIATEAIENFRTIVSLTREQKFETMYAQSLQVPYRNAMKKAHVFGITFS 941
Query: 1017 FACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKA-I 841
F + +F YA F+FG +LV ++ + + LV + A AG+ ++ PD+ KA +
Sbjct: 942 FTQAMMYFSYAACFRFGAYLVAQQLMTFENVMLVFSAVVFGAMAAGNTSSFAPDYAKAKV 1001
Query: 840 HAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAG 661
A+ +I + P I Y + K + G ++ V F Y R + +L G+SL++ G
Sbjct: 1002 SASHIIRIIEKTPEIDSYSTEGLKPTLLEGNVKFNGVQFNYPTRPNIPVLQGLSLEVKKG 1061
Query: 660 RTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLF 481
+TLALVG SG GKST++ LLERFY + G V +D + + +N+ LR + +VSQEP+LF
Sbjct: 1062 QTLALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAHLGIVSQEPILF 1121
Query: 480 NCSIKENFLFGISHNA-SQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQR 304
+CSI EN +G + A S EI +A K AN F+ P +T VG++G QLSGGQKQR
Sbjct: 1122 DCSIAENIAYGDNSRAVSHEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQR 1181
Query: 303 IAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSI 124
IAIARA++R P +LLLDEATSALD++SEKVVQ ALD A E + +V+AHRLST+ NAD I
Sbjct: 1182 IAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLI 1241
Query: 123 AVLKNGKVAEQGTHEELLRKRSIYWRLVQ 37
V++NGKV E GTH++LL ++ IY+ +VQ
Sbjct: 1242 VVIENGKVKEHGTHQQLLAQKGIYFSMVQ 1270
Score = 332 bits (852), Expect = 3e-89
Identities = 193/494 (39%), Positives = 290/494 (58%), Gaps = 3/494 (0%)
Frame = -1
Query: 1488 KLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLA 1309
K+R F +M+ ++D H L+ RL D S + + D++G ++ L
Sbjct: 145 KIRQKFFHAIMNQEIGWFD--VHDVGELNTRLTDDVSKINDGIGDKIGMFFQSITTFLAG 202
Query: 1308 VIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRT 1129
I+ F WK++L +L PL+ L+ + ++ A+ K+ A E L +RT
Sbjct: 203 FIIGFISGWKLTLVILAVSPLIGLSSALWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRT 262
Query: 1128 VRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLR 949
V A + + + +L++ +N K+A+ + G A + YA++F +GT LVL
Sbjct: 263 VIAFGGQQKELERYNKNLEEAKNVGIKKAITASISIGIAYLLVYASYALAFWYGTSLVLS 322
Query: 948 EEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFHLF-TYPAIMPYDSSQG 772
E + V ++ + G + A AA IF + P+I + +
Sbjct: 323 NEYSIGEVLTVFFSILLGTFSIGHLAPNIEAFANARGAAFEIFKIIDNEPSIDSFSTKGY 382
Query: 771 KRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERF 592
K + G +E KNV F Y RS+ IL G++LK+ +G+T+ALVG SG GKST + L++R
Sbjct: 383 KPDSIMGNLEFKNVHFNYPSRSEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRL 442
Query: 591 YHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQ 412
Y ++G V ID +++ +N+ +LRE + +VSQEPVLF +I EN +G + + EI++
Sbjct: 443 YDPLEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYG-REDVTMDEIEK 501
Query: 411 ALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALD 232
A+K ANA+ F+ + P DTLVGERGAQLSGGQKQRIAIARA++RNPK+LLLDEATSALD
Sbjct: 502 AVKEANAYDFIMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALD 561
Query: 231 SDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIY 52
++SE VVQ ALD A E +T+V+AHRLSTV NAD IA G + EQG H+EL+R++ IY
Sbjct: 562 TESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIY 621
Query: 51 WRLV--QKQGIQVE 16
++LV Q +G ++E
Sbjct: 622 FKLVMTQTRGNEIE 635
>gi|126928|sp|P21449|MDR2_CRIGR Multidrug resistance protein 2
(P-glycoprotein 2)
gi|191167|gb|AAA68884.1| p-glycoprotein isoform II
Length = 1276
Score = 746 bits (1926), Expect = 0.0
Identities = 451/1235 (36%), Positives = 684/1235 (54%), Gaps = 26/1235 (2%)
Frame = -1
Query: 3663 EKLLFFLGVVFSILTGMCQPF---------ESYTLGETSQVLVKVTNA--INNKTIDPVD 3517
+KL LG + ++L G P +S+T ETS + +TN INN +
Sbjct: 47 DKLYMVLGTLAAVLHGTSLPLLMLVFGNMTDSFTKAETS-IWPNMTNQSEINNTEVISGS 105
Query: 3516 LAHAYKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKD 3337
L E DM + +G ++Q S +R+++ ++ ++
Sbjct: 106 L-------EEDMATYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQINKIRQKFFHAIMNQE 158
Query: 3336 ISYFDGMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGT 3157
I +FD G L+ L D++ + + +KI + + F+ I+ F + W+L
Sbjct: 159 IGWFDVHDIGELNTRLTDDVSKINDGIGDKIGMFFQSIATFLAAFIVGFISGWKLTLVIL 218
Query: 3156 VFSFGIVLSGLLDSWGKMKNN--EKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERY 2983
S I LS + W K+ + K+ + + AG++A + L +TV + GQ +E+ERY
Sbjct: 219 AVSPLIGLSSAM--WAKVLTSFTNKELQAYAKAGAVAEEVLAAIRTVIAFGGQNKELERY 276
Query: 2982 TEELKNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYY 2803
+ L+ + + +A ++S Y A + ++G +++ G V+ + +
Sbjct: 277 NKNLEEAKNVGIKKAVTANISIGIAYLLVYASYALAFWYGTSLVLSNEYSVGQVLTVFFS 336
Query: 2802 ILFGSYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKN 2626
ILFG++ +G +I A+A I I+ D++ + D F ++ K D+ G + FKN
Sbjct: 337 ILFGTFSIGHIAPNIEVFANARGAAYEIFKII-DNEPSIDSFSTQGHKPDSVMGNLEFKN 395
Query: 2625 VLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGN 2446
V FSYP+R + +LK ++ VQ G+ +ALVG SG GKST +QLL Y+ G +SIDG
Sbjct: 396 VHFSYPSRSGIKILKGLNLKVQSGQTVALVGKSGCGKSTTVQLLQRLYDPTEGVVSIDGQ 455
Query: 2445 DIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNF 2266
DI IN++ LR+ +GVV QEPVLF T+I ENIR+G+ + T EI A+K ANA+DF+
Sbjct: 456 DIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKL 515
Query: 2265 PDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKA 2086
P T+VGERGAQLSGGQKQRIAIAR LVRNP+ILLLDEATSALD ESE +VQ AL KA
Sbjct: 516 PHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKA 575
Query: 2085 SIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYE 1906
GRTTIV+AHRLST+RNA+ I + G IVE G+H++L+ G+Y LV Q E
Sbjct: 576 REGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEELMKEKGIYCRLVMMQTRGNEVE 635
Query: 1905 KMNE----NEERVTRQSSHSDFPSNEISHQK----IDQEDDYVKKLIAEIKEEGAKKSNI 1750
+E + + + + +F S + +D + + E ++E +
Sbjct: 636 LGSEADGSQSDTIASELTSEEFKSPSVRKSTCRSICGSQDQERRVSVKEAQDEDVPLVSF 695
Query: 1749 CEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWALSI 1570
I+K +E+ L + VL + I G P+ S + + D D + + S+
Sbjct: 696 WGILKLNITEWPYLVVGVLCAVINGCMQPVFSIVFSGIIGVFTRDDDPKTKQQNCNLFSL 755
Query: 1569 LFLAFTRPIFI--FFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNR 1396
FL F+ FFQ + FGK E L+ +LR M FK ++ +++DD ++ L+ R
Sbjct: 756 FFLVMGMICFVTYFFQGFTFGKAGEILTKRLRYMVFKSMLRQDISWFDDHRNSTGALTTR 815
Query: 1395 LNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDN 1216
L +D++NV A+ RL + + + +I+S Y W+++L +++ PL+ L+G
Sbjct: 816 LASDAANVKGAMSSRLAGITQNVANLGTGIIISLVYGWQLTLLLVVIAPLIILSGMMEMK 875
Query: 1215 FVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVI 1036
+ +D E S + A EA+EN RTV +L E + + LQ + K+A +
Sbjct: 876 VLSGQALKDKKELEVSGKIATEAIENFRTVVSLTREQKFENMYAQSLQIPYRNALKKAHV 935
Query: 1035 QGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPD 856
G F + +F YA F+FG +LV + + + LV + A AG+A ++ PD
Sbjct: 936 FGITFSFTQAMMYFSYAACFRFGAYLVAHQIMTFENVMLVFSAVVFGAIAAGNASSFAPD 995
Query: 855 HRKA-IHAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVS 679
+ KA + A+ +I + P+I Y + K N G ++ V F Y R D +L G+S
Sbjct: 996 YAKAKVSASHIIRIMEKIPSIDSYSTRGLKPNWLEGNVKFNEVVFNYPTRPDIPVLQGLS 1055
Query: 678 LKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVS 499
L++ G+TLALVG SG GKST++ LLERFY + G V +D + + +N+ LR + +VS
Sbjct: 1056 LEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEIKQLNVQWLRAHLGIVS 1115
Query: 498 QEPVLFNCSIKENFLFG-ISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLS 322
QEP+LF+CSI EN +G S SQ EI++A K AN F+ P +T VG++G QLS
Sbjct: 1116 QEPILFDCSIAENIAYGDNSRVVSQDEIERAAKEANIHQFIESLPDKYNTRVGDKGTQLS 1175
Query: 321 GGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTV 142
GGQKQRIAIARA++R P +LLLDEATSALD++SEKVVQ ALD A E + +V+AHRLST+
Sbjct: 1176 GGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTI 1235
Query: 141 VNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQ 37
NAD I V++NGKV E GTH++LL ++ IY+ +VQ
Sbjct: 1236 QNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVQ 1270
Score = 339 bits (869), Expect = 3e-91
Identities = 204/513 (39%), Positives = 294/513 (56%), Gaps = 3/513 (0%)
Frame = -1
Query: 1545 IFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTA 1366
I + Q F+ A + K+R F +M+ ++D H L+ RL D S +
Sbjct: 126 IVAYIQVSFWCLAAGRQINKIRQKFFHAIMNQEIGWFD--VHDIGELNTRLTDDVSKIND 183
Query: 1365 AVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDS 1186
+ D++G ++ L A I+ F WK++L +L PL+ L+ + ++
Sbjct: 184 GIGDKIGMFFQSIATFLAAFIVGFISGWKLTLVILAVSPLIGLSSAMWAKVLTSFTNKEL 243
Query: 1185 IAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACS 1006
A+ K+ A E L +RTV A +N+ + +L++ +N K+AV + G A
Sbjct: 244 QAYAKAGAVAEEVLAAIRTVIAFGGQNKELERYNKNLEEAKNVGIKKAVTANISIGIAYL 303
Query: 1005 CYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGL 826
+ YA++F +GT LVL E V ++ G + A AA
Sbjct: 304 LVYASYALAFWYGTSLVLSNEYSVGQVLTVFFSILFGTFSIGHIAPNIEVFANARGAAYE 363
Query: 825 IFHLF-TYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLA 649
IF + P+I + + K + G +E KNV F Y RS IL G++LK+ +G+T+A
Sbjct: 364 IFKIIDNEPSIDSFSTQGHKPDSVMGNLEFKNVHFSYPSRSGIKILKGLNLKVQSGQTVA 423
Query: 648 LVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSI 469
LVG SG GKST + LL+R Y +G V ID +++ +N+ +LRE + +VSQEPVLF +I
Sbjct: 424 LVGKSGCGKSTTVQLLQRLYDPTEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTI 483
Query: 468 KENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIAR 289
EN +G N + EI++A+K ANA+ F+ + P DTLVGERGAQLSGGQKQRIAIAR
Sbjct: 484 AENIRYG-RENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIAR 542
Query: 288 AILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKN 109
A++RNPK+LLLDEATSALD++SE VVQ ALD A E +T+V+AHRLSTV NAD IA
Sbjct: 543 ALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDG 602
Query: 108 GKVAEQGTHEELLRKRSIYWRLV--QKQGIQVE 16
G + EQG HEEL++++ IY RLV Q +G +VE
Sbjct: 603 GVIVEQGNHEELMKEKGIYCRLVMMQTRGNEVE 635
>gi|38073917|ref|XP_283101.2| similar to multidrug resistance
p-glycoprotein [Mus musculus]
Length = 1214
Score = 746 bits (1925), Expect = 0.0
Identities = 437/1164 (37%), Positives = 663/1164 (56%), Gaps = 14/1164 (1%)
Frame = -1
Query: 3489 SDMNRVVLLFFL-VGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMS 3313
+D+ + L+++ +G A FG++Q S +R+Q+ +L +DIS+FDG
Sbjct: 60 TDLKGGLTLYYIGIGAAALIFGYVQISFWVITAARQTTRIRKQFFHSILAQDISWFDGSD 119
Query: 3312 TGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVL 3133
L+ + ++ + + +KI L+ ++ F IG +++ W+L+ S I+
Sbjct: 120 ICELNTRMTGDINKLCDGIGDKIPLMFQNISGFSIGLVISLIKSWKLSLVVLSTSPLIMA 179
Query: 3132 SGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKY 2953
S L S + K+ + S AG++A +AL +TV++ Q++E++RYT+ LK+ +
Sbjct: 180 SSALCSRMIISLTSKELDAYSKAGAVAEEALSSIQTVTAFGAQEKEIQRYTQHLKDAKDA 239
Query: 2952 ALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPG----VVVRILYYILFGSY 2785
+ RA LS A YFF N + ++G ++I+ G EPG ++ + + ++ SY
Sbjct: 240 GIKRATASKLSLGAVYFFMNGAYGLAFWYGTSLIFGG--EPGYTIGTILAVFFSVIHSSY 297
Query: 2784 CLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEE-IKDTFQGIISFKNVLFSYP 2608
C+G H+ A I ++ D D F + + + +G I FKNV FSYP
Sbjct: 298 CIGSVAPHLETFTVARGAAFNIFQVI-DKKPNIDNFSTAGFVPECIEGNIEFKNVSFSYP 356
Query: 2607 TRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNIN 2428
+RP VLK ++ ++ GE +ALVG SGSGKST +QLL Y+ + G I++D NDI N
Sbjct: 357 SRPSAKVLKGLNLKIKAGETVALVGPSGSGKSTTVQLLQRLYDPEDGCITVDENDIRAQN 416
Query: 2427 IKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKT 2248
++ R+ +GVV QEPVLF T+I NI+FG+ E+E+ A + ANA+DF+ FP T
Sbjct: 417 VRHYREQIGVVRQEPVLFGTTIGNNIKFGREGVGEKEMEQAAREANAYDFIMAFPKKFNT 476
Query: 2247 IVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTT 2068
+VGE+GAQ+SGGQKQRIAIAR LVRNP+IL+LDEATSALD ESE +VQ AL+KAS GRTT
Sbjct: 477 LVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDTESESLVQTALEKASKGRTT 536
Query: 2067 IVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNENE 1888
IVVAHRLSTIR A+ I+ M+ G +VE G H +L+A G+Y +L Q + E+M E
Sbjct: 537 IVVAHRLSTIRGADLIVTMKDGMVVEKGTHAELMAKQGLYYSLAMAQDIKKVDEQM---E 593
Query: 1887 ERVTRQSSHSDFPS----NEISHQKIDQEDDYVKKLIAEIKEEGAKKSNICEIIKYCRSE 1720
R + ++ + S N DQ ++ V + E ++ +I K +SE
Sbjct: 594 SRTCSTAGNASYGSLCDVNSAKAPCTDQLEEAVHHQKTSLPE-----VSLLKIFKLSKSE 648
Query: 1719 YCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSK--SHFWALSILFLAFTRP 1546
+ + + L SA+ G +P+ S + K + DK++ K + +++ ++ L
Sbjct: 649 WPFVVLGTLASALNGSVHPVFSIIFGKLVTMFE-DKNKATLKQDAELYSMMLVVLGIVAL 707
Query: 1545 IFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTA 1366
+ Q F+G+ E L+++LR +FK ++ A+YDD + L+ L D + +
Sbjct: 708 VTYLMQGLFYGRAEENLAMRLRHSAFKAMLYQDMAWYDDKENNTGALTTTLAVDVAQIQG 767
Query: 1365 AVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDS 1186
A RLG V + + L++++SF Y W+M+L +L F P+L + G + D
Sbjct: 768 AATSRLGIVTQDVSNMSLSILISFIYGWEMTLLILSFAPVLAVTGMIQTAAMAGFANRDK 827
Query: 1185 IAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACS 1006
A +++ + A EA+EN+RTV +L E + LQ + KRA I G + +
Sbjct: 828 QALKRAGKIATEAVENIRTVVSLTRERAFEQMYEETLQTQHRNALKRAHITGCCYAVSHA 887
Query: 1005 CYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGL 826
F +A F+FG +L+ ++P ++V ++ A G + + P++ KA A
Sbjct: 888 FVHFAHAAGFRFGAYLIQAGRMMPEGMFIVFTAIAYGAMAIGETLVWAPEYSKAKAGASH 947
Query: 825 IFHLF-TYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLA 649
+F L P I S K + G +E + VSF Y R + +L +SL + G+T+A
Sbjct: 948 LFALLKNKPTINSCSQSGEKPDTCEGNLEFREVSFVYPCRPEVPVLQNMSLSIEKGKTVA 1007
Query: 648 LVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSI 469
VG SG GKST + LL+RFY + G+V +D +V ++N+ LR ++VSQEPVLFNCSI
Sbjct: 1008 FVGSSGCGKSTCVQLLQRFYDPMKGQVLLDGVDVKELNVQWLRSQTAIVSQEPVLFNCSI 1067
Query: 468 KENFLFGISHNASQL-EIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIA 292
EN +G + L EI + AN SF+ P+ +TLVG RG QLSGGQKQR+AIA
Sbjct: 1068 AENIAYGDNSRMVPLEEIKEVADAANIHSFIEGLPRKYNTLVGLRGVQLSGGQKQRLAIA 1127
Query: 291 RAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLK 112
RA+LR PK+LLLDEATSALD++SEKVVQ ALD A + +VVAHRLST+ NAD I VL+
Sbjct: 1128 RALLRKPKILLLDEATSALDNESEKVVQQALDKARRGKTCLVVAHRLSTIQNADMIVVLQ 1187
Query: 111 NGKVAEQGTHEELLRKRSIYWRLV 40
NG + EQGTH+ELLR Y++LV
Sbjct: 1188 NGSIKEQGTHQELLRNGDTYFKLV 1211
Score = 327 bits (839), Expect = 1e-87
Identities = 195/516 (37%), Positives = 298/516 (56%), Gaps = 8/516 (1%)
Frame = -1
Query: 1545 IFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYD--DPCHTATRLSNRLNADSSNV 1372
IF + Q F+ TA + + ++R F +++ +++D D C L+ R+ D + +
Sbjct: 79 IFGYVQISFWVITAARQTTRIRKQFFHSILAQDISWFDGSDICE----LNTRMTGDINKL 134
Query: 1371 TAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEE 1192
+ D++ + + + +++S SWK+SL VL PL+ + + +
Sbjct: 135 CDGIGDKIPLMFQNISGFSIGLVISLIKSWKLSLVVLSTSPLIMASSALCSRMIISLTSK 194
Query: 1191 DSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFA 1012
+ A+ K+ A EAL +++TV A + + I T HL+ +++ KRA + G
Sbjct: 195 ELDAYSKAGAVAEEALSSIQTVTAFGAQEKEIQRYTQHLKDAKDAGIKRATASKLSLG-- 252
Query: 1011 CSCYFFI---YAVSFKFGTWLVLREEI-LPMDTYLVLMTLSMTASYA-GSAVAYLPDHRK 847
+ YFF+ Y ++F +GT L+ E + T L + + +SY GS +L
Sbjct: 253 -AVYFFMNGAYGLAFWYGTSLIFGGEPGYTIGTILAVFFSVIHSSYCIGSVAPHLETFTV 311
Query: 846 AIHAAGLIFHLFTY-PAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKL 670
A AA IF + P I + ++ G IE KNVSF Y R +L G++LK+
Sbjct: 312 ARGAAFNIFQVIDKKPNIDNFSTAGFVPECIEGNIEFKNVSFSYPSRPSAKVLKGLNLKI 371
Query: 669 PAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEP 490
AG T+ALVGPSGSGKST + LL+R Y DG + +DE ++ N+ H RE + +V QEP
Sbjct: 372 KAGETVALVGPSGSGKSTTVQLLQRLYDPEDGCITVDENDIRAQNVRHYREQIGVVRQEP 431
Query: 489 VLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQK 310
VLF +I N FG + E++QA + ANA+ F+ FP+ +TLVGE+GAQ+SGGQK
Sbjct: 432 VLFGTTIGNNIKFG-REGVGEKEMEQAAREANAYDFIMAFPKKFNTLVGEKGAQMSGGQK 490
Query: 309 QRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNAD 130
QRIAIARA++RNPK+L+LDEATSALD++SE +VQ AL+ AS+ +T+VVAHRLST+ AD
Sbjct: 491 QRIAIARALVRNPKILILDEATSALDTESESLVQTALEKASKGRTTIVVAHRLSTIRGAD 550
Query: 129 SIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQ 22
I +K+G V E+GTH EL+ K+ +Y+ L Q I+
Sbjct: 551 LIVTMKDGMVVEKGTHAELMAKQGLYYSLAMAQDIK 586
>gi|25453402|ref|NP_596892.1| ATP-binding cassette, sub-family B
(MDR/TAP), member 1A; multiple drug resistant 1a [Rattus
norvegicus]
gi|34853968|ref|XP_346684.1| hypothetical protein XP_346683 [Rattus
norvegicus]
gi|7739773|gb|AAF69007.1| multidrug resistance protein 1a [Rattus
norvegicus]
Length = 1272
Score = 745 bits (1924), Expect = 0.0
Identities = 441/1230 (35%), Positives = 676/1230 (54%), Gaps = 19/1230 (1%)
Frame = -1
Query: 3663 EKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFESD 3484
++ LG + +I+ G+ P G+ + N NN+++ + Y E +
Sbjct: 46 DRFYMLLGTLAAIIHGIALPLMMLVFGDMTD---SFANVGNNRSMSFYNATDIYAKLEDE 102
Query: 3483 MNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMSTGH 3304
M + +G ++Q S+ + +R+++ ++ ++I +FD G
Sbjct: 103 MTTYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVGE 162
Query: 3303 LSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGL 3124
L+ L D++ + E +KI + + F G I+ F W+L + + VL
Sbjct: 163 LNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTL--VILAISPVLGLS 220
Query: 3123 LDSWGKMKNN--EKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYA 2950
W K+ ++ +K+ + + AG++A + L +TV + GQ++E+ERY L+ ++
Sbjct: 221 AGIWAKILSSFTDKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEAKRLG 280
Query: 2949 LNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEA 2770
+ +A ++S A + A + ++G +++ G V+ + + +L G++ +G+A
Sbjct: 281 IKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYTIGQVLTVFFSVLIGAFSVGQA 340
Query: 2769 ILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPTRPDV 2593
+I A+A + I+ D+ + D F K D QG + FKN+ FSYP+R DV
Sbjct: 341 SPNIEAFANARGAAYEVFSII-DNKPSIDSFSKSGHKPDNIQGNLEFKNIHFSYPSRKDV 399
Query: 2592 PVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLR 2413
+LK ++ V+ G+ +ALVG SG GKST +QLL Y+ G +SIDG DI IN++ LR
Sbjct: 400 QILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEGEVSIDGQDIRTINVRYLR 459
Query: 2412 QAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGER 2233
+ +GVV QEPVLF T+I ENIR+G+ + T EI A+K ANA+DF+ P T+VGER
Sbjct: 460 EIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGER 519
Query: 2232 GAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAH 2053
GAQLSGGQKQRIAIAR LVRNP+ILLLDEATSALD ESE +VQ AL KA GRTTIV+AH
Sbjct: 520 GAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAH 579
Query: 2052 RLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNENEER--- 1882
RLST+RNA+ I + G IVE G+H +L+ G+Y LV TQ E NE E
Sbjct: 580 RLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTAGNEIELGNEACESKDG 639
Query: 1881 -----VTRQSSHSDFPSNEISHQKI----DQEDDYVKKLIAEIKEEGAKKSNICEIIKYC 1729
++ + S S + + I DQ+ + K E ++ ++ I+K
Sbjct: 640 IDNVDMSSKDSGSSLIRRRSTRKSIRGPHDQDGELSTK---EALDDDVPPASFWRILKLN 696
Query: 1728 RSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSK--SHFWALSILFLAF 1555
+E+ + V + I G P S + K + + + + S+ ++L L L
Sbjct: 697 STEWPYFVVGVFCAIINGGLQPAFSIIFSKVVGVFTKNDTPEIQRQNSNLFSLLFLILGI 756
Query: 1554 TRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSN 1375
I F Q + FGK E L+ +LR M FK ++ +++DDP +T L+ RL D++
Sbjct: 757 ISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDISWFDDPKNTTGALTTRLANDAAQ 816
Query: 1374 VTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVE 1195
V A RL + + + +I+S Y W+++L +L P++ +AG +
Sbjct: 817 VKGATGSRLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQAL 876
Query: 1194 EDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGF 1015
+D E S + A EA+EN RTV +L E + + LQ + K+A + G F
Sbjct: 877 KDKKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNALKKAHVFGITFSF 936
Query: 1014 ACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKA-IH 838
+ +F YA F+FG +LV RE + + LV + A G ++ PD+ KA +
Sbjct: 937 TQAMMYFSYAACFRFGAYLVARELMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKAKVS 996
Query: 837 AAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGR 658
A+ +I + P I Y + K N+ G ++ V F Y R + +L G+SL++ G+
Sbjct: 997 ASHIIRIIEKIPEIDSYSTEGLKPNMLEGNVKFNGVMFNYPTRPNIPVLQGLSLEVKKGQ 1056
Query: 657 TLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFN 478
TLALVG SG GKST++ LLERFY + G V +D + + +N+ LR + +VSQEP+LF+
Sbjct: 1057 TLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEIKQLNVQWLRAHLGIVSQEPILFD 1116
Query: 477 CSIKENFLFG-ISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRI 301
CSI EN +G S S EI +A K AN F+ P+ +T VG++G QLSGGQKQRI
Sbjct: 1117 CSIAENIAYGDNSRVVSHEEIVKAAKEANIHQFIDSLPEKYNTRVGDKGTQLSGGQKQRI 1176
Query: 300 AIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIA 121
AIARA++R P +LLLDEATSALD++SEKVVQ ALD A E + +V+AHRLST+ NAD I
Sbjct: 1177 AIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIV 1236
Query: 120 VLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
V++NG+V E GTH++LL ++ IY+ +V Q
Sbjct: 1237 VIQNGQVKEHGTHQQLLAQKGIYFSMVSVQ 1266
>gi|46394986|gb|AAS91649.1| multidrug resistance protein 1a;
P-glycoprotein [Rattus norvegicus]
Length = 1272
Score = 742 bits (1915), Expect = 0.0
Identities = 440/1230 (35%), Positives = 675/1230 (54%), Gaps = 19/1230 (1%)
Frame = -1
Query: 3663 EKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFESD 3484
++ LG + +I+ G+ P G+ + N NN+++ + Y + +
Sbjct: 46 DRFYMLLGTLAAIIHGIALPLMMLVFGDMTD---SFANVGNNRSMSFYNATDIYAKLKDE 102
Query: 3483 MNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMSTGH 3304
M + +G ++Q S+ + +R+++ ++ ++I +FD G
Sbjct: 103 MTTYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVGE 162
Query: 3303 LSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGL 3124
L+ L D++ + E +KI + + F G I+ F W+L + + VL
Sbjct: 163 LNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTL--VILAISPVLGLS 220
Query: 3123 LDSWGKMKNN--EKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYA 2950
W K+ ++ +K+ + + AG++A + L +TV + GQ++E+ERY L+ ++
Sbjct: 221 AGIWAKILSSFTDKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEAKRLG 280
Query: 2949 LNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEA 2770
+ +A ++S A + A + ++G +++ G V+ + + +L G++ +G+A
Sbjct: 281 IKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYTIGQVLTVFFSVLIGAFSVGQA 340
Query: 2769 ILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPTRPDV 2593
+I A+A + I+ D+ + D F K D QG + FKN+ FSYP+R DV
Sbjct: 341 SPNIEAFANARGAAYEVFSII-DNKPSIDSFSKSGHKPDNIQGNLEFKNIHFSYPSRKDV 399
Query: 2592 PVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLR 2413
+LK ++ V+ G+ +ALVG SG GKST +QLL Y+ G +SIDG DI IN++ LR
Sbjct: 400 QILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEGEVSIDGQDIRTINVRYLR 459
Query: 2412 QAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGER 2233
+ +GVV QEPVLF T+I ENIR+G+ + T EI A+K ANA+DF+ P T+VGER
Sbjct: 460 EIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGER 519
Query: 2232 GAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAH 2053
GAQLSGGQKQRIAIAR LVRNP+ILLLDEATSALD ESE +VQ AL KA GRTTIV+AH
Sbjct: 520 GAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAH 579
Query: 2052 RLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNENEER--- 1882
RLST+RNA+ I + G IVE G+H +L+ G+Y LV TQ E NE E
Sbjct: 580 RLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTAGNEIELGNEACESKDG 639
Query: 1881 -----VTRQSSHSDFPSNEISHQKI----DQEDDYVKKLIAEIKEEGAKKSNICEIIKYC 1729
++ + S S + + I DQ+ + K E ++ ++ I+K
Sbjct: 640 IDNVDMSSKDSGSSLIRRRSTRKSIRGPHDQDGELSTK---EALDDDVPPASFWRILKLN 696
Query: 1728 RSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSK--SHFWALSILFLAF 1555
+E+ + V + I G P S + K + + + + S+ ++L L L
Sbjct: 697 STEWPYFVVGVFCAIINGGLQPAFSIIFSKVVGVFTKNDTPEIQRQNSNLFSLLFLILGI 756
Query: 1554 TRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSN 1375
I F Q + FGK E L+ +LR M FK ++ +++DDP +T L+ RL D++
Sbjct: 757 ISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDISWFDDPKNTTGALTTRLANDAAQ 816
Query: 1374 VTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVE 1195
V A RL + + + +I+S Y W+++L +L P++ +AG +
Sbjct: 817 VKGATGSRLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQAL 876
Query: 1194 EDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGF 1015
+D E S + A EA+EN RTV +L E + + LQ + K+A + G F
Sbjct: 877 KDKKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNALKKAHVFGITFSF 936
Query: 1014 ACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKA-IH 838
+ +F YA F+FG +LV RE + + LV + A G ++ PD+ KA +
Sbjct: 937 TQAMMYFSYAACFRFGAYLVARELMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKAKVS 996
Query: 837 AAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGR 658
A+ +I + P I Y + K N+ G ++ V F Y R + +L G+SL+ G+
Sbjct: 997 ASHIIRIIEKIPEIDSYSTEGLKPNMLEGNVKFNGVMFNYPTRPNIPVLQGLSLEGKKGQ 1056
Query: 657 TLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFN 478
TLALVG SG GKST++ LLERFY + G V +D + + +N+ LR + +VSQEP+LF+
Sbjct: 1057 TLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEIKQLNVQWLRAHLGIVSQEPILFD 1116
Query: 477 CSIKENFLFG-ISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRI 301
CSI EN +G S S EI +A K AN F+ P+ +T VG++G QLSGGQKQRI
Sbjct: 1117 CSIAENIAYGDNSRVVSHEEIVKAAKEANIHQFIDSLPEKYNTRVGDKGTQLSGGQKQRI 1176
Query: 300 AIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIA 121
AIARA++R P +LLLDEATSALD++SEKVVQ ALD A E + +V+AHRLST+ NAD I
Sbjct: 1177 AIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIV 1236
Query: 120 VLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
V++NG+V E GTH++LL ++ IY+ +V Q
Sbjct: 1237 VIQNGQVKEHGTHQQLLAQKGIYFSMVSVQ 1266
>gi|6755048|ref|NP_035206.1| ATP-binding cassette, sub-family B
(MDR/TAP), member 1A; P glycoprotein 3; ATP-binding
cassette, sub-family B (MDR/TAP), member 4; multi-drug
resistance 3; P-glycoprotein; multiple drug resistant 1a
[Mus musculus]
gi|387427|gb|AAA39514.1| P-glycoprotein
Length = 1276
Score = 740 bits (1911), Expect = 0.0
Identities = 437/1228 (35%), Positives = 668/1228 (53%), Gaps = 17/1228 (1%)
Frame = -1
Query: 3663 EKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKT-IDPVDLAHAYKLFES 3487
++L +G + +I+ G+ P G+ + V N N T + D + E
Sbjct: 46 DRLYMLVGTLAAIIHGVALPLMMLIFGDMTDSFASVGNVSKNSTNMSEADKRAMFAKLEE 105
Query: 3486 DMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMSTG 3307
+M + +G ++Q S + +R+++ ++ ++I +FD G
Sbjct: 106 EMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVG 165
Query: 3306 HLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSG 3127
L+ L D++ + E +KI + + F G I+ F W+L + + VL
Sbjct: 166 ELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTL--VILAISPVLGL 223
Query: 3126 LLDSWGKMKNN--EKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKY 2953
W K+ ++ +K+ + AG++A + L +TV + GQ++E+ERY L+ ++
Sbjct: 224 SAGIWAKILSSFTDKELHAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEAKRL 283
Query: 2952 ALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGE 2773
+ +A ++S A + A + ++G +++ G V+ + + +L G++ +G+
Sbjct: 284 GIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYSIGQVLTVFFSVLIGAFSVGQ 343
Query: 2772 AILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPTRPD 2596
A +I A+A + I+ D+ + D F K D QG + FKN+ FSYP+R +
Sbjct: 344 ASPNIEAFANARGAAYEVFKII-DNKPSIDSFSKSGHKPDNIQGNLEFKNIHFSYPSRKE 402
Query: 2595 VPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQL 2416
V +LK ++ V+ G+ +ALVG SG GKST +QL+ Y+ G +SIDG DI IN++ L
Sbjct: 403 VQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRYL 462
Query: 2415 RQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGE 2236
R+ +GVV QEPVLF T+I ENIR+G+ D T EI A+K ANA+DF+ P T+VGE
Sbjct: 463 REIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPHQFDTLVGE 522
Query: 2235 RGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVA 2056
RGA +SGGQKQRIAIAR LVRNP+ILLLDEATSALD ESE +VQ AL KA GRTTIV+A
Sbjct: 523 RGAHVSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIA 582
Query: 2055 HRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNE------ 1894
HRLST+RNA+ I + G IVE G+H +L+ G+Y LV TQ E NE
Sbjct: 583 HRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTAGNEIELGNEACKSKD 642
Query: 1893 --NEERVTRQSSHSDFPSNEISHQKIDQEDDYVKKL-IAEIKEEGAKKSNICEIIKYCRS 1723
+ ++ + S S + + I D +KL E +E ++ I+K +
Sbjct: 643 EIDNLDMSSKDSGSSLIRRRSTRKSICGPHDQDRKLSTKEALDEDVPPASFWRILKLNST 702
Query: 1722 EYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAY--AFDKDEMLSKSHFWALSILFLAFTR 1549
E+ + + + I G P S + K + + S+ ++L L L
Sbjct: 703 EWPYFVVGIFCAIINGGLQPAFSVIFSKVVGVFTNGGPPETQRQNSNLFSLLFLILGIIS 762
Query: 1548 PIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVT 1369
I F Q + FGK E L+ +LR M FK ++ +++DDP +T L+ RL D++ V
Sbjct: 763 FITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTRLANDAAQVK 822
Query: 1368 AAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEED 1189
A RL + + + +I+S Y W+++L +L P++ +AG + +D
Sbjct: 823 GATGSRLAVIFQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKD 882
Query: 1188 SIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFAC 1009
E S + A EA+EN RTV +L E + + LQ + K+A + G F
Sbjct: 883 KKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNAMKKAHVFGITFSFTQ 942
Query: 1008 SCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKA-IHAA 832
+ +F YA F+FG +LV ++ + + LV + A G ++ PD+ KA + A+
Sbjct: 943 AMMYFSYAACFRFGAYLVTQQLMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKATVSAS 1002
Query: 831 GLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTL 652
+I + P I Y + K N+ G ++ V F Y R +L G+SL++ G+TL
Sbjct: 1003 HIIRIIEKTPEIDSYSTQGLKPNMLEGNVQFSGVVFNYPTRPSIPVLQGLSLEVKKGQTL 1062
Query: 651 ALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCS 472
ALVG SG GKST++ LLERFY + G V +D + + +N+ LR + +VSQEP+LF+CS
Sbjct: 1063 ALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAQLGIVSQEPILFDCS 1122
Query: 471 IKENFLFG-ISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAI 295
I EN +G S S EI +A K AN F+ P +T VG++G QLSGGQKQRIAI
Sbjct: 1123 IAENIAYGDNSRVVSYEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAI 1182
Query: 294 ARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVL 115
ARA++R P +LLLDEATSALD++SEKVVQ ALD A E + +V+AHRLST+ NAD I V+
Sbjct: 1183 ARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVI 1242
Query: 114 KNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
+NGKV E GTH++LL ++ IY+ +V Q
Sbjct: 1243 QNGKVKEHGTHQQLLAQKGIYFSMVSVQ 1270
>gi|266517|sp|P21447|MDR3_MOUSE Multidrug resistance protein 3
(P-glycoprotein 3) (MDR1A)
gi|110720|pir||A34786 multidrug resistance protein 1a - mouse
gi|387429|gb|AAA39517.1| multidrug resistance protein
Length = 1276
Score = 740 bits (1911), Expect = 0.0
Identities = 438/1228 (35%), Positives = 668/1228 (53%), Gaps = 17/1228 (1%)
Frame = -1
Query: 3663 EKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKT-IDPVDLAHAYKLFES 3487
++L +G + +I+ G+ P G+ + V N N T + D + E
Sbjct: 46 DRLYMLVGTLAAIIHGVALPLMMLIFGDMTDSFASVGNVSKNSTNMSEADKRAMFAKLEE 105
Query: 3486 DMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMSTG 3307
+M + +G ++Q S + +R+++ ++ ++I +FD G
Sbjct: 106 EMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVG 165
Query: 3306 HLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSG 3127
L+ L D++ + E +KI + + F G I+ F W+L + + VL
Sbjct: 166 ELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTL--VILAISPVLGL 223
Query: 3126 LLDSWGKMKNN--EKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKY 2953
W K+ ++ +K+ + AG++A + L +TV + GQ++E+ERY L+ ++
Sbjct: 224 SAGIWAKILSSFTDKELHAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEAKRL 283
Query: 2952 ALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGE 2773
+ +A ++S A + A + ++G +++ G V+ + + +L G++ +G+
Sbjct: 284 GIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYSIGQVLTVFFSVLIGAFSVGQ 343
Query: 2772 AILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPTRPD 2596
A +I A+A + I+ D+ + D F K D QG + FKN+ FSYP+R +
Sbjct: 344 ASPNIEAFANARGAAYEVFKII-DNKPSIDSFSKSGHKPDNIQGNLEFKNIHFSYPSRKE 402
Query: 2595 VPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQL 2416
V +LK ++ V+ G+ +ALVG SG GKST +QL+ Y+ G +SIDG DI IN++ L
Sbjct: 403 VQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRYL 462
Query: 2415 RQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGE 2236
R+ +GVV QEPVLF T+I ENIR+G+ D T EI A+K ANA+DF+ P T+VGE
Sbjct: 463 REIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPHQFDTLVGE 522
Query: 2235 RGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVA 2056
RGAQLSGGQKQRIAIAR LVRNP+ILLLDEATSALD ESE +VQ AL KA GRTTIV+A
Sbjct: 523 RGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIA 582
Query: 2055 HRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNE------ 1894
HRLST+RNA+ I + G IVE G+H +L+ G+Y LV TQ E NE
Sbjct: 583 HRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTAGNEIELGNEACKSKD 642
Query: 1893 --NEERVTRQSSHSDFPSNEISHQKIDQEDDYVKKL-IAEIKEEGAKKSNICEIIKYCRS 1723
+ ++ + S S + + I D +KL E +E ++ I+K +
Sbjct: 643 EIDNLDMSSKDSGSSLIRRRSTRKSICGPHDQDRKLSTKEALDEDVPPASFWRILKLNST 702
Query: 1722 EYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAY--AFDKDEMLSKSHFWALSILFLAFTR 1549
E+ + + + I G P S + K + + S+ ++L L L
Sbjct: 703 EWPYFVVGIFCAIINGGLQPAFSVIFSKVVGVFTNGGPPETQRQNSNLFSLLFLILGIIS 762
Query: 1548 PIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVT 1369
I F Q + FGK E L+ +LR M FK ++ +++DDP +T L+ RL D++ V
Sbjct: 763 FITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTRLANDAAQVK 822
Query: 1368 AAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEED 1189
A RL + + + +I+S Y W+++L +L P++ +AG + +D
Sbjct: 823 GATGSRLAVIFQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKD 882
Query: 1188 SIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFAC 1009
E S + A EA+EN RTV +L E + + LQ + K+A + G F
Sbjct: 883 KKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNAMKKAHVFGITFFFTQ 942
Query: 1008 SCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKA-IHAA 832
+ +F YA F+FG +LV ++ + + LV + A G ++ PD+ KA + A+
Sbjct: 943 AMMYFSYAACFRFGAYLVTQQLMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKATVSAS 1002
Query: 831 GLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTL 652
+I + P I Y + K N+ G ++ F Y R +L G+SL++ G+TL
Sbjct: 1003 HIIRIIEKTPEIDSYSTQGLKPNMLEGNVQFSGFVFNYPTRPSIPVLQGLSLEVKKGQTL 1062
Query: 651 ALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCS 472
ALVG SG GKST++ LLERFY + G V +D + + +N+ LR + +VSQEP+LF+CS
Sbjct: 1063 ALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAQLGIVSQEPILFDCS 1122
Query: 471 IKENFLFG-ISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAI 295
I EN +G S S EI +A K AN F+ P +T VG++G QLSGGQKQRIAI
Sbjct: 1123 IAENIAYGDNSRVVSYEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAI 1182
Query: 294 ARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVL 115
ARA++R P +LLLDEATSALD++SEKVVQ ALD A E + +V+AHRLST+ NAD I V+
Sbjct: 1183 ARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVI 1242
Query: 114 KNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
+NGKV E GTH++LL ++ IY+ +V Q
Sbjct: 1243 QNGKVKEHGTHQQLLAQKGIYFSMVSVQ 1270
>gi|307180|gb|AAA59575.1| P-glycoprotein [Homo sapiens]
Length = 1280
Score = 740 bits (1910), Expect = 0.0
Identities = 446/1234 (36%), Positives = 670/1234 (54%), Gaps = 23/1234 (1%)
Frame = -1
Query: 3663 EKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVK-------VTNAINNKTIDPVDLAHA 3505
+KL +G + +I+ G P GE + + ++N N I+
Sbjct: 47 DKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDINDTGF--- 103
Query: 3504 YKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYF 3325
+ E DM R + +G ++Q S + +R+Q+ ++R++I +F
Sbjct: 104 FMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWF 163
Query: 3324 DGMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSF 3145
D G L+ L D++ + EV +KI + + F G I+ F W+L S
Sbjct: 164 DVHDVGELNTRLTDDVSKINEVIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISP 223
Query: 3144 GIVLSGLLDSWGKMKNNEKQNEHIS--NAGSIAFQALGCYKTVSSLNGQQQEVERYTEEL 2971
+ LS + W K+ ++ E ++ AG++A + L +TV + GQ++E+ERY + L
Sbjct: 224 VLGLSAAV--WAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNL 281
Query: 2970 KNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFG 2791
+ ++ + +A ++S A + A + ++G ++ G G V+ + + +L G
Sbjct: 282 EEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIG 341
Query: 2790 SYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFS 2614
++ +G+A I A+A I I+ D+ + D + K D +G + F+NV FS
Sbjct: 342 AFSVGQASPSIEAFANARGAAYEIFKII-DNKPSIDSYSKSGHKPDNIKGNLEFRNVHFS 400
Query: 2613 YPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYN 2434
YP+R +V +LK ++ VQ G+ +ALVG SG GKST +QL+ Y+ G +S+DG DI
Sbjct: 401 YPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRT 460
Query: 2433 INIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGI 2254
IN++ LR+ +GVV QEPVLF T+I ENIR+G+ + T EI A+K ANA+DF+ P
Sbjct: 461 INVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKF 520
Query: 2253 KTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGR 2074
T+VGERGAQLSGGQKQRIAIAR LVRNP+ILLLDEATSALD ESE +VQ AL KA GR
Sbjct: 521 DTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGR 580
Query: 2073 TTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNE 1894
TTIV+AHRLST+RNA+ I + G IVE G+H +L+ G+Y LV Q E N
Sbjct: 581 TTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENA 640
Query: 1893 NEE--------RVTRQSSHSDFPSNEISHQKIDQEDDYVKKL-IAEIKEEGAKKSNICEI 1741
+E ++ S S + + + +KL E +E + I
Sbjct: 641 ADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRI 700
Query: 1740 IKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWALSILFL 1561
+K +E+ + V + I G P + + K + D + + S+LFL
Sbjct: 701 MKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFL 760
Query: 1560 AFTRPIFI--FFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNA 1387
A FI F Q + FGK E L+ +LR M F+ ++ +++DDP +T L+ RL
Sbjct: 761 ALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLAN 820
Query: 1386 DSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVD 1207
D++ V A+ RL + + + +I+SF Y W+++L +L P++ +AG +
Sbjct: 821 DAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLS 880
Query: 1206 QAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGT 1027
+D E + + A EA+EN RTV +L E + + LQ + ++A I G
Sbjct: 881 GQALKDKKELEGAGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGI 940
Query: 1026 ANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRK 847
F + +F YA F+FG +LV + + D LV + A G ++ PD+ K
Sbjct: 941 TFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAK 1000
Query: 846 A-IHAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKL 670
A I AA +I + P I Y + N G + V F Y R D +L G+SL++
Sbjct: 1001 AKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEV 1060
Query: 669 PAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEP 490
G+TLALVG SG GKST++ LLERFY + G+V +D + + +N+ LR + +VSQEP
Sbjct: 1061 KKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEP 1120
Query: 489 VLFNCSIKENFLFG-ISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQ 313
+LF+CSI EN +G S SQ EI +A K AN +F+ P T VG++G QLSGGQ
Sbjct: 1121 ILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQ 1180
Query: 312 KQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNA 133
KQRIAIARA++R P +LLLDEATSALD++SEKVVQ ALD A E + +V+AHRLST+ NA
Sbjct: 1181 KQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNA 1240
Query: 132 DSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
D I V +NG+V E GTH++LL ++ IY+ +V Q
Sbjct: 1241 DLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ 1274
Score = 329 bits (844), Expect = 3e-88
Identities = 194/510 (38%), Positives = 293/510 (57%), Gaps = 3/510 (0%)
Frame = -1
Query: 1536 FFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVD 1357
+ Q F+ A + K+R F +M ++D H L+ RL D S + +
Sbjct: 130 YIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFD--VHDVGELNTRLTDDVSKINEVIG 187
Query: 1356 DRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAF 1177
D++G ++ I+ F WK++L +L P+L L+ + +++ +A+
Sbjct: 188 DKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAY 247
Query: 1176 EKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYF 997
K+ A E L +RTV A + + + +L++ + K+A+ + G A +
Sbjct: 248 AKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIY 307
Query: 996 FIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFH 817
YA++F +GT LVL E V ++ + A G A + A AA IF
Sbjct: 308 ASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFK 367
Query: 816 LF-TYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVG 640
+ P+I Y S K + G +E +NV F Y R + IL G++LK+ +G+T+ALVG
Sbjct: 368 IIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVG 427
Query: 639 PSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKEN 460
SG GKST + L++R Y +G V +D +++ +N+ LRE + +VSQEPVLF +I EN
Sbjct: 428 NSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAEN 487
Query: 459 FLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAIL 280
+G N + EI++A+K ANA+ F+ + P DTLVGERGAQLSGGQKQRIAIARA++
Sbjct: 488 IRYG-RENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALV 546
Query: 279 RNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKV 100
RNPK+LLLDEATSALD++SE VVQ ALD A + +T+V+AHRLSTV NAD IA +G +
Sbjct: 547 RNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVI 606
Query: 99 AEQGTHEELLRKRSIYWRLV--QKQGIQVE 16
E+G H+EL++++ IY++LV Q G +VE
Sbjct: 607 VEKGNHDELMKEKGIYFKLVTMQTAGNEVE 636
>gi|27656757|gb|AAO20901.1| Mdr3 [Takifugu rubripes]
Length = 1292
Score = 740 bits (1910), Expect = 0.0
Identities = 447/1264 (35%), Positives = 687/1264 (53%), Gaps = 51/1264 (4%)
Frame = -1
Query: 3669 RYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFE 3490
R++ +L G V +++ G P GE + + A +N + +
Sbjct: 53 RWDVVLLISGTVMAMVNGTVMPLMCIVFGEMTDSFIYADMAQHNASGWNSTTTILNSTLQ 112
Query: 3489 SDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMST 3310
DM R + + ++GF ++Q S +R + +++++IS+FD T
Sbjct: 113 EDMQRFAIYYSVLGFVVLLAAYMQVSFWTITAGRQVKRIRSLFFHCIMQQEISWFDVNDT 172
Query: 3309 GHLSIVLND------------------------------NMERFREVFNEKIALIIALLT 3220
G L+ L + ++ + +E +K+ L+I T
Sbjct: 173 GELNTRLTEEFPASAFTLCTATLGGVDDLMDVLLFSNGSDVYKIQEGIGDKVGLLIQAYT 232
Query: 3219 DFVIGTILAFYTDWRLACYGTVFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQAL 3040
F+ I+ F T W+L S + +S S K+ + AG++A + L
Sbjct: 233 TFITAFIIGFTTGWKLTLVILAVSPALAISAAFFSKVLASFTSKEQTAYAKAGAVAEEVL 292
Query: 3039 GCYKTVSSLNGQQQEVERYTEELKNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGA 2860
+TV + +GQ +E+ERY + L++ + + +A +++ + + ++G+
Sbjct: 293 SAIRTVFAFSGQTREIERYHKNLRDAKDVGVKKAISSNIAMGFTFLMIYLSYALAFWYGS 352
Query: 2859 NMIYEGTIEPGVVVRILYYILFGSYCLGEAILHISRLASAIPLTVPIADILLDSDATADE 2680
+I G ++ + + +L G++ +G+ +I ASA + I+ D+ D
Sbjct: 353 TLILNFEYTIGNLLTVFFVVLIGAFSVGQTSPNIQNFASARGAAYKVYSII-DNKPNIDS 411
Query: 2679 FFSEEIKDTF-QGIISFKNVLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVI 2503
F + K F +G I FKN+ F+YP+RP+V +L +S +V+ G+ IALVG+SG GKST I
Sbjct: 412 FSEDGFKPDFIKGDIEFKNIHFNYPSRPEVKILNNMSLSVKSGQTIALVGSSGCGKSTTI 471
Query: 2502 QLLLHYYNIDSGRISIDGNDIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATE 2323
QLL +Y+ + G + IDG+DI ++NI+ LR+ +GVV QEPVLF T+I ENIR+G+ D T+
Sbjct: 472 QLLQRFYDPEEGAVFIDGHDIRSLNIRYLREMIGVVSQEPVLFATTITENIRYGRLDVTQ 531
Query: 2322 QEIIDALKNANAFDFVCNFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEA 2143
+EI A K +NA+DF+ N PD +T+VG+RG QLSGGQKQRIAIAR LVRNP+ILLLDEA
Sbjct: 532 EEIERATKESNAYDFIMNLPDKFETLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEA 591
Query: 2142 TSALDNESEFIVQEALQKASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIA 1963
TSALD ESE IVQ AL K +GRTTIVVAHRLSTIRNA+ I G+IVE G H QL+
Sbjct: 592 TSALDAESETIVQAALDKVRLGRTTIVVAHRLSTIRNADIIAGFSNGKIVEQGTHSQLME 651
Query: 1962 MNGVYNNLVQTQLM------STNYEKMNENE----ERVTRQSS--------HSDFPSNEI 1837
+ GVY+ LV Q +T +++ E E+ QSS S F ++E
Sbjct: 652 IKGVYHGLVTMQTFHNVEEENTAMSELSAGEKSPVEKTVSQSSIIRRKSTRGSSFAASEG 711
Query: 1836 SHQKIDQEDDYVKKLIAEIKEEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLS 1657
+ ++ +ED+ V + + +++ E+ + + ++ + I G P+
Sbjct: 712 TKEEKTEEDEDVPDV------------SFFKVLHLNIPEWPYILVGLICATINGAMQPVF 759
Query: 1656 SQLMIKSYEAYAF-DKDEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLR 1480
+ L K +A D+D + KS F +L + + + +F Q Y FGK+ E L++KLR
Sbjct: 760 AILFSKIITVFADPDRDSVRRKSEFISLMFVVIGCVSFVTMFLQGYCFGKSGEILTLKLR 819
Query: 1479 SMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIM 1300
+F +M ++YD+P +T L+ RL AD++ V A RL +++ + ++I+
Sbjct: 820 LRAFTAMMRQDLSWYDNPQNTVGALTTRLAADAAQVQGAAGVRLATIMQNFANLGTSIII 879
Query: 1299 SFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRA 1120
+F Y W+++L +L PL+ AG + +D EK+ + A EA+ENVRTV +
Sbjct: 880 AFVYGWELTLLILAVVPLIAAAGAAEIKLLAGHAAKDKKELEKAGKIATEAIENVRTVVS 939
Query: 1119 LNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEI 940
L+ E + L +L+ + K+A + G F+ + +F YA F+FG WL+ +
Sbjct: 940 LSREPKFECLYEENLRVPYKNSQKKAHVYGLTYSFSQAMIYFAYAACFRFGAWLIEAGRM 999
Query: 939 LPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGKRNI 760
+LV+ + A G A + P++ KA AA + L + S +G
Sbjct: 1000 DVEGVFLVVSAVLYGAMAVGEANTFAPNYAKAKMAASYLMMLINKKPAIDNLSEEGTSPE 1059
Query: 759 K-NGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHA 583
K +G + + V F Y R D IL G++LK+ G TLALVG SG GKST I LLERFY
Sbjct: 1060 KYDGNVHFEGVKFNYPSRPDVTILQGLNLKVKKGETLALVGSSGCGKSTTIQLLERFYDP 1119
Query: 582 VDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALK 403
+G V +D NV +N+H LR + +VSQEPVLF+CS+ EN +G N+ + +D+
Sbjct: 1120 REGRVSLDGVNVKQLNIHWLRSQIGIVSQEPVLFDCSLAENIAYG--DNSRSVSMDEI-- 1175
Query: 402 VANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDS 223
DT G++G QLSGGQKQR+AIARAI+RNPK+LLLDEATSALD++S
Sbjct: 1176 -------------RYDTQAGDKGTQLSGGQKQRVAIARAIIRNPKLLLLDEATSALDTES 1222
Query: 222 EKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRL 43
EKVVQ ALD A + + +VVAHRLST+ NAD IAV + G V E+GTH++L+ K+ +Y L
Sbjct: 1223 EKVVQEALDQARKGRTCIVVAHRLSTIQNADCIAVFQGGVVVEKGTHQQLIAKKGVYHML 1282
Query: 42 VQKQ 31
V KQ
Sbjct: 1283 VTKQ 1286
Score = 281 bits (720), Expect = 7e-74
Identities = 187/523 (35%), Positives = 286/523 (53%), Gaps = 6/523 (1%)
Frame = -1
Query: 3474 VVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGM--STGHL 3301
+ L+F ++G F FLQ G+ +R + + ++R+D+S++D + G L
Sbjct: 785 ISLMFVVIGCVSFVTMFLQGYCFGKSGEILTLKLRLRAFTAMMRQDLSWYDNPQNTVGAL 844
Query: 3300 SIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLL 3121
+ L + + + ++A I+ + I+AF W L I +G
Sbjct: 845 TTRLAADAAQVQGAAGVRLATIMQNFANLGTSIIIAFVYGWELTLLILAVVPLIAAAGAA 904
Query: 3120 DSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNR 2941
+ + K + + AG IA +A+ +TV SL+ + + Y E L+ K + +
Sbjct: 905 EIKLLAGHAAKDKKELEKAGKIATEAIENVRTVVSLSREPKFECLYEENLRVPYKNSQKK 964
Query: 2940 AFVFSLSRS---ADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEA 2770
A V+ L+ S A +F A F FGA +I G ++ V ++ +L+G+ +GEA
Sbjct: 965 AHVYGLTYSFSQAMIYFAYAACF---RFGAWLIEAGRMDVEGVFLVVSAVLYGAMAVGEA 1021
Query: 2769 ILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPTRPDV 2593
A A + +L++ D E + + G + F+ V F+YP+RPDV
Sbjct: 1022 NTFAPNYAKA-KMAASYLMMLINKKPAIDNLSEEGTSPEKYDGNVHFEGVKFNYPSRPDV 1080
Query: 2592 PVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLR 2413
+L+ ++ V+ GE +ALVG+SG GKST IQLL +Y+ GR+S+DG ++ +NI LR
Sbjct: 1081 TILQGLNLKVKKGETLALVGSSGCGKSTTIQLLERFYDPREGRVSLDGVNVKQLNIHWLR 1140
Query: 2412 QAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGER 2233
+G+V QEPVLF+ S+ ENI +G D + +D ++ T G++
Sbjct: 1141 SQIGIVSQEPVLFDCSLAENIAYG--DNSRSVSMDEIR--------------YDTQAGDK 1184
Query: 2232 GAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAH 2053
G QLSGGQKQR+AIAR ++RNP++LLLDEATSALD ESE +VQEAL +A GRT IVVAH
Sbjct: 1185 GTQLSGGQKQRVAIARAIIRNPKLLLLDEATSALDTESEKVVQEALDQARKGRTCIVVAH 1244
Query: 2052 RLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQL 1924
RLSTI+NA+ I V + G +VE G H+QLIA GVY+ LV Q+
Sbjct: 1245 RLSTIQNADCIAVFQGGVVVEKGTHQQLIAKKGVYHMLVTKQM 1287
>gi|1170902|sp|P43245|MDR1_RAT Multidrug resistance protein 1
(P-glycoprotein 1)
gi|92489|pir||JH0502 p-glycoprotein - rat
Length = 1277
Score = 739 bits (1909), Expect = 0.0
Identities = 450/1234 (36%), Positives = 685/1234 (55%), Gaps = 25/1234 (2%)
Frame = -1
Query: 3663 EKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTI---DPVDLAHAYK-- 3499
+KL LG + +I+ G P G + + +++ I ++ H
Sbjct: 45 DKLCMALGTLAAIIHGTLLPLLMLVFGYMTDSFTPSRDPHSDRAITNQSEINSTHTVSDT 104
Query: 3498 LFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDG 3319
E DM + +G ++Q S+ + +R+++ ++ ++I +FD
Sbjct: 105 SLEEDMAMYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFFHAIMNQEIGWFDV 164
Query: 3318 MSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGI 3139
G L+ L D++ + + +K+ + +T F G I+ F + W+L S I
Sbjct: 165 NDAGELNTRLTDDVSKINDGIGDKLGMFFQSITTFSAGFIIGFISGWKLTLVILAVSPLI 224
Query: 3138 VLSGLLDSWGKMKNN--EKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKN 2965
LS + W K+ + K+ + + AG++A + L +TV + GQ++E+ERY + L+
Sbjct: 225 GLSSAM--WAKVLTSFTNKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEE 282
Query: 2964 GEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSY 2785
++ + +A ++S Y A + ++G +++ G V+ + + IL G++
Sbjct: 283 AKRVGIKKAITANISIGIAYLLVYASYALAFWYGTSLVLSNEYSIGQVLTVFFSILLGTF 342
Query: 2784 CLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYP 2608
+G +I A+A I I+ D++ + D F ++ K D+ G + FKNV F+YP
Sbjct: 343 SIGHLAPNIEAFANARGAAYEIFKII-DNEPSIDSFSTKGHKPDSIMGNLEFKNVYFNYP 401
Query: 2607 TRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNIN 2428
+R +V +LK ++ V+ G+ +ALVG SG GKST +QLL Y+ G +SIDG DI IN
Sbjct: 402 SRSEVKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEGEVSIDGQDIRTIN 461
Query: 2427 IKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKT 2248
++ LR+ +GVV QEPVLF T+I ENIR+G+ + T EI A+K ANA+DF+ P T
Sbjct: 462 VRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDT 521
Query: 2247 IVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTT 2068
+VGERGAQLSGGQKQRIAIAR LVRNP+ILLLDEATSALD ESE +VQ AL KA GRTT
Sbjct: 522 LVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTT 581
Query: 2067 IVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNENE 1888
IV+AHRLST+RNA+ I + G IVE G+H++L+ G+Y LV TQ E N
Sbjct: 582 IVIAHRLSTVRNADVIAGFDGGVIVEQGNHEELMKEKGIYFKLVMTQTRGNEIEPGNNAY 641
Query: 1887 E--------RVTRQSSHSDFPSNEIS---HQKIDQEDDYVKKLIAEIKEEGAKKSNICEI 1741
E +T + S S I H++ DQE K E +E + +I
Sbjct: 642 ESQSDTGASELTSEESKSPLIRRSIRRSIHRRQDQERRLSSK---EDVDEDVPMVSFWQI 698
Query: 1740 IKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWALSILFL 1561
+K SE+ L + VL + I G P+ + + K ++ D D + + S+LFL
Sbjct: 699 LKLNISEWPYLVVGVLCAVINGCIQPVFAIVFSKIVGVFSRDDDHETKQRNCNLFSLLFL 758
Query: 1560 AFTRPIFI--FFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNA 1387
F+ FFQ + FGK E L+ +LR M FK ++ +++DD +T L+ RL +
Sbjct: 759 VMGMISFVTYFFQGFTFGKAGEILTKRLRYMVFKSMLRQDISWFDDHKNTTGSLTTRLAS 818
Query: 1386 DSSNVTAAVDDRLGSVIMTLVAILLAVIMS--FFYSWKMSLQVLMFCPLLYLAGYCNDNF 1213
D+SNV A+ RL V + + +I+S Y W+++L +++ PL+ L G
Sbjct: 819 DASNVKGAMGSRLAVVTQNVANLGTGIILSLVLVYGWQLTLLLVVIIPLIVLGGIIEMKL 878
Query: 1212 VDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQ 1033
+ +D E S + A EA+EN RTV +L E + + LQ + K+A +
Sbjct: 879 LSGQALKDKKELEISGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNALKKAHVF 938
Query: 1032 GTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDH 853
G F + +F YA F+FG +LV RE + + LV + A AG+ ++ PD+
Sbjct: 939 GITFAFTQAMIYFSYAACFRFGAYLVARELMTFENVMLVFSAVVFGAMAAGNTSSFAPDY 998
Query: 852 RKA-IHAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSL 676
KA + A+ +I + P I Y + K N G ++ V F Y R + +L G+S
Sbjct: 999 AKAKVSASHIIGIIEKIPEIDSYSTEGLKPNWLEGNVKFNGVKFNYPTRPNIPVLQGLSF 1058
Query: 675 KLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQ 496
++ G+TL LVG SG GKST++ LLERFY+ + G V +D + + +N+ +R ++ +VSQ
Sbjct: 1059 EVKKGQTLRLVGSSGCGKSTVVQLLERFYNPMAGTVFLDGKEIKQLNVQCVR-ALGIVSQ 1117
Query: 495 EPVLFNCSIKENFLFG-ISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSG 319
EP+LF+CSI EN +G S S EI +A + AN F+ P+ +T VG++G QLSG
Sbjct: 1118 EPILFDCSIAENIAYGDNSRVVSHEEIVRAAREANIHQFIDSLPEKYNTRVGDKGTQLSG 1177
Query: 318 GQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVV 139
GQKQRIAIARA++R P +LLLDEATSALD++SEKVVQ ALD A E + VV+AHRLST+
Sbjct: 1178 GQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCVVIAHRLSTIQ 1237
Query: 138 NADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQ 37
NAD I V++NG+V E GTH++LL ++ IY+ +VQ
Sbjct: 1238 NADLIVVIQNGQVKEHGTHQQLLAQKGIYFSMVQ 1271
Score = 332 bits (852), Expect = 3e-89
Identities = 195/494 (39%), Positives = 289/494 (58%), Gaps = 3/494 (0%)
Frame = -1
Query: 1488 KLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLA 1309
K+R F +M+ ++D + A L+ RL D S + + D+LG ++
Sbjct: 145 KIRQKFFHAIMNQEIGWFD--VNDAGELNTRLTDDVSKINDGIGDKLGMFFQSITTFSAG 202
Query: 1308 VIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRT 1129
I+ F WK++L +L PL+ L+ + ++ A+ K+ A E L +RT
Sbjct: 203 FIIGFISGWKLTLVILAVSPLIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRT 262
Query: 1128 VRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLR 949
V A + + + +L++ + K+A+ + G A + YA++F +GT LVL
Sbjct: 263 VIAFGGQKKELERYNKNLEEAKRVGIKKAITANISIGIAYLLVYASYALAFWYGTSLVLS 322
Query: 948 EEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFHLF-TYPAIMPYDSSQG 772
E V ++ + G + A AA IF + P+I + +
Sbjct: 323 NEYSIGQVLTVFFSILLGTFSIGHLAPNIEAFANARGAAYEIFKIIDNEPSIDSFSTKGH 382
Query: 771 KRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERF 592
K + G +E KNV F Y RS+ IL G++LK+ +G+T+ALVG SG GKST + LL+R
Sbjct: 383 KPDSIMGNLEFKNVYFNYPSRSEVKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRL 442
Query: 591 YHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQ 412
Y ++GEV ID +++ +N+ +LRE + +VSQEPVLF +I EN +G N + EI++
Sbjct: 443 YDPIEGEVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYG-RENVTMDEIEK 501
Query: 411 ALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALD 232
A+K ANA+ F+ + P DTLVGERGAQLSGGQKQRIAIARA++RNPK+LLLDEATSALD
Sbjct: 502 AVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALD 561
Query: 231 SDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIY 52
++SE VVQ ALD A E +T+V+AHRLSTV NAD IA G + EQG HEEL++++ IY
Sbjct: 562 TESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEELMKEKGIY 621
Query: 51 WRLV--QKQGIQVE 16
++LV Q +G ++E
Sbjct: 622 FKLVMTQTRGNEIE 635
>gi|42741659|ref|NP_000918.2| ATP-binding cassette sub-family B member
1; multidrug resistance 1; P glycoprotein 1; doxorubicin
resistance; colchicin sensitivity [Homo sapiens]
Length = 1280
Score = 738 bits (1906), Expect = 0.0
Identities = 446/1234 (36%), Positives = 669/1234 (54%), Gaps = 23/1234 (1%)
Frame = -1
Query: 3663 EKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVK-------VTNAINNKTIDPVDLAHA 3505
+KL +G + +I+ G P GE + + ++N N I+
Sbjct: 47 DKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDINDTGF--- 103
Query: 3504 YKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYF 3325
+ E DM R + +G ++Q S + +R+Q+ ++R++I +F
Sbjct: 104 FMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWF 163
Query: 3324 DGMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSF 3145
D G L+ L D++ + E +KI + + F G I+ F W+L S
Sbjct: 164 DVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISP 223
Query: 3144 GIVLSGLLDSWGKMKNNEKQNEHIS--NAGSIAFQALGCYKTVSSLNGQQQEVERYTEEL 2971
+ LS + W K+ ++ E ++ AG++A + L +TV + GQ++E+ERY + L
Sbjct: 224 VLGLSAAV--WAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNL 281
Query: 2970 KNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFG 2791
+ ++ + +A ++S A + A + ++G ++ G G V+ + + +L G
Sbjct: 282 EEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIG 341
Query: 2790 SYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFS 2614
++ +G+A I A+A I I+ D+ + D + K D +G + F+NV FS
Sbjct: 342 AFSVGQASPSIEAFANARGAAYEIFKII-DNKPSIDSYSKSGHKPDNIKGNLEFRNVHFS 400
Query: 2613 YPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYN 2434
YP+R +V +LK ++ VQ G+ +ALVG SG GKST +QL+ Y+ G +S+DG DI
Sbjct: 401 YPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRT 460
Query: 2433 INIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGI 2254
IN++ LR+ +GVV QEPVLF T+I ENIR+G+ + T EI A+K ANA+DF+ P
Sbjct: 461 INVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKF 520
Query: 2253 KTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGR 2074
T+VGERGAQLSGGQKQRIAIAR LVRNP+ILLLDEATSALD ESE +VQ AL KA GR
Sbjct: 521 DTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGR 580
Query: 2073 TTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNE 1894
TTIV+AHRLST+RNA+ I + G IVE G+H +L+ G+Y LV Q E N
Sbjct: 581 TTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENA 640
Query: 1893 NEE--------RVTRQSSHSDFPSNEISHQKIDQEDDYVKKL-IAEIKEEGAKKSNICEI 1741
+E ++ S S + + + +KL E +E + I
Sbjct: 641 ADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRI 700
Query: 1740 IKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWALSILFL 1561
+K +E+ + V + I G P + + K + D + + S+LFL
Sbjct: 701 MKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFL 760
Query: 1560 AFTRPIFI--FFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNA 1387
A FI F Q + FGK E L+ +LR M F+ ++ +++DDP +T L+ RL
Sbjct: 761 ALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLAN 820
Query: 1386 DSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVD 1207
D++ V A+ RL + + + +I+SF Y W+++L +L P++ +AG +
Sbjct: 821 DAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLS 880
Query: 1206 QAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGT 1027
+D E S + A EA+EN RTV +L E + + LQ + ++A I G
Sbjct: 881 GQALKDKKELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGI 940
Query: 1026 ANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRK 847
F + +F YA F+FG +LV + + D LV + A G ++ PD+ K
Sbjct: 941 TFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAK 1000
Query: 846 A-IHAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKL 670
A I AA +I + P I Y + N G + V F Y R D +L G+SL++
Sbjct: 1001 AKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEV 1060
Query: 669 PAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEP 490
G+TLALVG SG GKST++ LLERFY + G+V +D + + +N+ LR + +VSQEP
Sbjct: 1061 KKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEP 1120
Query: 489 VLFNCSIKENFLFG-ISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQ 313
+LF+CSI EN +G S SQ EI +A K AN +F+ P T VG++G QLSGGQ
Sbjct: 1121 ILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQ 1180
Query: 312 KQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNA 133
KQRIAIARA++R P +LLLDEATSALD++SEKVVQ ALD A E + +V+AHRLST+ NA
Sbjct: 1181 KQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNA 1240
Query: 132 DSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
D I V +NG+V E GTH++LL ++ IY+ +V Q
Sbjct: 1241 DLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ 1274
Score = 329 bits (844), Expect = 3e-88
Identities = 194/510 (38%), Positives = 293/510 (57%), Gaps = 3/510 (0%)
Frame = -1
Query: 1536 FFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVD 1357
+ Q F+ A + K+R F +M ++D H L+ RL D S + +
Sbjct: 130 YIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFD--VHDVGELNTRLTDDVSKINEGIG 187
Query: 1356 DRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAF 1177
D++G ++ I+ F WK++L +L P+L L+ + +++ +A+
Sbjct: 188 DKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAY 247
Query: 1176 EKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYF 997
K+ A E L +RTV A + + + +L++ + K+A+ + G A +
Sbjct: 248 AKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIY 307
Query: 996 FIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFH 817
YA++F +GT LVL E V ++ + A G A + A AA IF
Sbjct: 308 ASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFK 367
Query: 816 LF-TYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVG 640
+ P+I Y S K + G +E +NV F Y R + IL G++LK+ +G+T+ALVG
Sbjct: 368 IIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVG 427
Query: 639 PSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKEN 460
SG GKST + L++R Y +G V +D +++ +N+ LRE + +VSQEPVLF +I EN
Sbjct: 428 NSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAEN 487
Query: 459 FLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAIL 280
+G N + EI++A+K ANA+ F+ + P DTLVGERGAQLSGGQKQRIAIARA++
Sbjct: 488 IRYG-RENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALV 546
Query: 279 RNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKV 100
RNPK+LLLDEATSALD++SE VVQ ALD A + +T+V+AHRLSTV NAD IA +G +
Sbjct: 547 RNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVI 606
Query: 99 AEQGTHEELLRKRSIYWRLV--QKQGIQVE 16
E+G H+EL++++ IY++LV Q G +VE
Sbjct: 607 VEKGNHDELMKEKGIYFKLVTMQTAGNEVE 636
>gi|191157|gb|AAA37005.1| p-glycoprotein
Length = 1169
Score = 738 bits (1905), Expect = 0.0
Identities = 432/1157 (37%), Positives = 648/1157 (55%), Gaps = 16/1157 (1%)
Frame = -1
Query: 3453 VGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMSTGHLSIVLNDNME 3274
+G ++Q S + +R+++ ++ ++I +FD G L+ L D++
Sbjct: 11 IGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVGELNTRLTDDVS 70
Query: 3273 RFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLLDSWGKMKNN 3094
+ E +KI + + F G I+ F W+L + + VL W K+ ++
Sbjct: 71 KINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTL--VILAISPVLGLSAGIWAKILSS 128
Query: 3093 --EKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNRAFVFSLS 2920
+K+ + + AG++A + L +TV + GQ++E+ERY L+ ++ + +A ++S
Sbjct: 129 FTDKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEAKRLGIKKAITANIS 188
Query: 2919 RSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEAILHISRLASA 2740
A + A + ++G +++ G V+ + + +L + +G+A +I A+A
Sbjct: 189 MGAAFLLIYASYALAFWYGTSLVISKEYSIGQVLTVFFAVLIAPFSIGQASPNIEAFANA 248
Query: 2739 IPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPTRPDVPVLKEISFNV 2563
I +I+ D+ + D F K D +G + FKN+ FSYP+R DV +LK ++ V
Sbjct: 249 RGAAYEIFNII-DNKPSIDSFSKNGYKPDNIKGNLEFKNIHFSYPSRKDVQILKGLNLKV 307
Query: 2562 QGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAMGVVFQEP 2383
Q G+ +ALVG SG GKST +QLL Y+ G +SIDG DI IN++ LR+ +GVV QEP
Sbjct: 308 QSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGVVSIDGQDIRTINVRYLREIIGVVSQEP 367
Query: 2382 VLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGERGAQLSGGQKQ 2203
VLF T+I ENIR+G+ + T EI A+K ANA+DF+ P T+VGERGAQLSGGQKQ
Sbjct: 368 VLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQ 427
Query: 2202 RIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHRLSTIRNANK 2023
RIAIAR LVRNP+ILLLDEATSALD ESE +VQ AL KA GRTTIV+AHRLST+RNA+
Sbjct: 428 RIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADI 487
Query: 2022 IIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNENEER--------VTRQS 1867
I + G IVE G+H++L+ G+Y LV TQ E NE E ++ +
Sbjct: 488 IAGFDGGVIVEQGNHEELMREKGIYFKLVMTQTAGNEIELGNEVGESKNEIDNLDMSSKD 547
Query: 1866 SHSDFPSNEISHQKIDQEDDYVKKL-IAEIKEEGAKKSNICEIIKYCRSEYCILFIAVLG 1690
S S + + I D +KL E +E + I+K SE+ + +
Sbjct: 548 SASSLIRRRSTRRSIRGPHDQDRKLSTKEALDEDVPPISFWRILKLNSSEWPYFVVGIFC 607
Query: 1689 SAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSK--SHFWALSILFLAFTRPIFIFFQYYFF 1516
+ + G P S + K + + D+ + S+ ++L L L I F Q + F
Sbjct: 608 AIVNGALQPAFSIIFSKVVGVFTRNTDDETKRHDSNLFSLLFLILGVISFITFFLQGFTF 667
Query: 1515 GKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVI 1336
GK E L+ +LR M FK ++ +++D+P +T L+ RL D+ V A RL +
Sbjct: 668 GKAGEILTKRLRYMVFKSMLRQDVSWFDNPKNTTGALTTRLANDAGQVKGATGARLAVIT 727
Query: 1335 MTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAA 1156
+ + +I+S Y W+++L +L P++ +AG + +D E S + A
Sbjct: 728 QNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIA 787
Query: 1155 IEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSF 976
EA+EN RTV +L E + + LQ + K+A + G F + +F YA F
Sbjct: 788 TEAIENFRTVVSLTREQKFENMYAQSLQIPYRNALKKAHVFGITFSFTQAMMYFSYAACF 847
Query: 975 KFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKA-IHAAGLIFHLFTYPA 799
+FG +LV RE + + LV + A G ++ PD+ KA + A+ +I + P+
Sbjct: 848 RFGAYLVARELMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKAKVSASHIIMIIEKVPS 907
Query: 798 IMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKS 619
I Y + K N G ++ V F Y R D +L G++L++ G+TLALVG SG GKS
Sbjct: 908 IDSYSTGGLKPNTLEGNVKFNEVVFNYPTRPDIPVLQGLNLEVKKGQTLALVGSSGCGKS 967
Query: 618 TIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFG-IS 442
T++ LLERFY + G V +D + V +N+ LR + +VSQEP+LF+CSI EN +G S
Sbjct: 968 TVVQLLERFYDPMAGTVFLDGKEVNQLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNS 1027
Query: 441 HNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVL 262
SQ EI++A K AN F+ P +T VG++G QLSGGQKQRIAIARA++R P +L
Sbjct: 1028 RVVSQDEIERAAKEANIHQFIESLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHIL 1087
Query: 261 LLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTH 82
LLDEATSALD++SEKVVQ ALD A E + +V+AHRLST+ NAD I V++NGKV E GTH
Sbjct: 1088 LLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTH 1147
Query: 81 EELLRKRSIYWRLVQKQ 31
++LL ++ IY+ +V Q
Sbjct: 1148 QQLLAQKGIYFSMVSVQ 1164
Score = 322 bits (826), Expect = 3e-86
Identities = 205/586 (34%), Positives = 325/586 (54%), Gaps = 11/586 (1%)
Frame = -1
Query: 3651 FFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFESDMNRV 3472
F +G+ +I+ G QP S + KV T D D N
Sbjct: 601 FVVGIFCAIVNGALQPAFSI-------IFSKVVGVFTRNTDDETK--------RHDSNLF 645
Query: 3471 VLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDG--MSTGHLS 3298
LLF ++G F FLQ G+ +R +LR+D+S+FD +TG L+
Sbjct: 646 SLLFLILGVISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDNPKNTTGALT 705
Query: 3297 IVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLLD 3118
L ++ + + ++A+I + + G I++ W+L I ++G+++
Sbjct: 706 TRLANDAGQVKGATGARLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVE 765
Query: 3117 SWGKMKNNE--KQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALN 2944
KM + + K + + +G IA +A+ ++TV SL +Q+ Y + L+ + AL
Sbjct: 766 M--KMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFENMYAQSLQIPYRNALK 823
Query: 2943 RAFVFSLSRSADYFFTNALNF----VILYFGANMIYEGTIEPGVVVRILYYILFGSYCLG 2776
+A VF ++ + FT A+ + FGA ++ + V+ + I+FG+ +G
Sbjct: 824 KAHVFGIT----FSFTQAMMYFSYAACFRFGAYLVARELMTFENVLLVFSAIVFGAMAVG 879
Query: 2775 EAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPTRP 2599
+ A A ++ ++++ + D + + +K +T +G + F V+F+YPTRP
Sbjct: 880 QVSSFAPDYAKA-KVSASHIIMIIEKVPSIDSYSTGGLKPNTLEGNVKFNEVVFNYPTRP 938
Query: 2598 DVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQ 2419
D+PVL+ ++ V+ G+ +ALVG+SG GKSTV+QLL +Y+ +G + +DG ++ +N++
Sbjct: 939 DIPVLQGLNLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEVNQLNVQW 998
Query: 2418 LRQAMGVVFQEPVLFNTSIEENIRFGKPD--ATEQEIIDALKNANAFDFVCNFPDGIKTI 2245
LR +G+V QEP+LF+ SI ENI +G ++ EI A K AN F+ + PD T
Sbjct: 999 LRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIERAAKEANIHQFIESLPDKYNTR 1058
Query: 2244 VGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTI 2065
VG++G QLSGGQKQRIAIAR LVR P ILLLDEATSALD ESE +VQEAL KA GRT I
Sbjct: 1059 VGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCI 1118
Query: 2064 VVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQ 1927
V+AHRLSTI+NA+ I+V++ G++ E G H+QL+A G+Y ++V Q
Sbjct: 1119 VIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQ 1164
>gi|2506118|sp|P08183|MDR1_HUMAN Multidrug resistance protein 1
(P-glycoprotein 1) (CD243 antigen)
gi|1070659|pir||DVHU1 multidrug resistance protein 1 - human
gi|386862|gb|AAA59576.1| P glycoprotein
Length = 1280
Score = 737 bits (1903), Expect = 0.0
Identities = 445/1234 (36%), Positives = 669/1234 (54%), Gaps = 23/1234 (1%)
Frame = -1
Query: 3663 EKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVK-------VTNAINNKTIDPVDLAHA 3505
+KL +G + +I+ G P GE + + ++N N I+
Sbjct: 47 DKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDINDTGF--- 103
Query: 3504 YKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYF 3325
+ E DM R + +G ++Q S + +R+Q+ ++R++I +F
Sbjct: 104 FMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWF 163
Query: 3324 DGMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSF 3145
D G L+ L D++ + E +KI + + F G I+ F W+L S
Sbjct: 164 DVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISP 223
Query: 3144 GIVLSGLLDSWGKMKNNEKQNEHIS--NAGSIAFQALGCYKTVSSLNGQQQEVERYTEEL 2971
+ LS + W K+ ++ E ++ AG++A + L +TV + GQ++E+ERY + L
Sbjct: 224 VLGLSAAV--WAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNL 281
Query: 2970 KNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFG 2791
+ ++ + +A ++S A + A + ++G ++ G G V+ + + +L G
Sbjct: 282 EEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIG 341
Query: 2790 SYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFS 2614
++ +G+A I A+A I I+ D+ + D + K D +G + F+NV FS
Sbjct: 342 AFSVGQASPSIEAFANARGAAYEIFKII-DNKPSIDSYSKSGHKPDNIKGNLEFRNVHFS 400
Query: 2613 YPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYN 2434
YP+R +V +LK ++ VQ G+ +ALVG SG GKST +QL+ Y+ G +S+DG DI
Sbjct: 401 YPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRT 460
Query: 2433 INIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGI 2254
IN++ LR+ +GVV QEPVLF T+I ENIR+G+ + T EI A+K ANA+DF+ P
Sbjct: 461 INVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKF 520
Query: 2253 KTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGR 2074
T+VGERGAQLSGGQKQRIAIAR LVRNP+ILLLDEATSALD ESE +VQ AL KA GR
Sbjct: 521 DTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGR 580
Query: 2073 TTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNE 1894
TTIV+AHRLST+RNA+ I + G IVE G+H +L+ G+Y LV Q E N
Sbjct: 581 TTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENA 640
Query: 1893 NEE--------RVTRQSSHSDFPSNEISHQKIDQEDDYVKKL-IAEIKEEGAKKSNICEI 1741
+E ++ S S + + + +KL E +E + I
Sbjct: 641 ADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRI 700
Query: 1740 IKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWALSILFL 1561
+K +E+ + V + I G P + + K + D + + S+LFL
Sbjct: 701 MKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFL 760
Query: 1560 AFTRPIFI--FFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNA 1387
A FI F Q + FGK E L+ +LR M F+ ++ +++DDP +T L+ RL
Sbjct: 761 ALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLAN 820
Query: 1386 DSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVD 1207
D++ V A+ RL + + + +I+SF Y W+++L +L P++ +AG +
Sbjct: 821 DAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLS 880
Query: 1206 QAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGT 1027
+D E + + A EA+EN RTV +L E + + LQ + ++A I G
Sbjct: 881 GQALKDKKELEGAGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGI 940
Query: 1026 ANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRK 847
F + +F YA F+FG +LV + + D LV + A G ++ PD+ K
Sbjct: 941 TFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAK 1000
Query: 846 A-IHAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKL 670
A I AA +I + P I Y + N G + V F Y R D +L G+SL++
Sbjct: 1001 AKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEV 1060
Query: 669 PAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEP 490
G+TLALVG SG GKST++ LLERFY + G+V +D + + +N+ LR + +VSQEP
Sbjct: 1061 KKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEP 1120
Query: 489 VLFNCSIKENFLFG-ISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQ 313
+LF+CSI EN +G S SQ EI +A K AN +F+ P T VG++G QLSGGQ
Sbjct: 1121 ILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQ 1180
Query: 312 KQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNA 133
KQRIAIARA++R P +LLLDEATSALD++SEKVVQ ALD A E + +V+AHRLST+ NA
Sbjct: 1181 KQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNA 1240
Query: 132 DSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
D I V +NG+V E GTH++LL ++ IY+ +V Q
Sbjct: 1241 DLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ 1274
Score = 329 bits (844), Expect = 3e-88
Identities = 194/510 (38%), Positives = 293/510 (57%), Gaps = 3/510 (0%)
Frame = -1
Query: 1536 FFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVD 1357
+ Q F+ A + K+R F +M ++D H L+ RL D S + +
Sbjct: 130 YIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFD--VHDVGELNTRLTDDVSKINEGIG 187
Query: 1356 DRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAF 1177
D++G ++ I+ F WK++L +L P+L L+ + +++ +A+
Sbjct: 188 DKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAY 247
Query: 1176 EKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYF 997
K+ A E L +RTV A + + + +L++ + K+A+ + G A +
Sbjct: 248 AKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIY 307
Query: 996 FIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFH 817
YA++F +GT LVL E V ++ + A G A + A AA IF
Sbjct: 308 ASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFK 367
Query: 816 LF-TYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVG 640
+ P+I Y S K + G +E +NV F Y R + IL G++LK+ +G+T+ALVG
Sbjct: 368 IIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVG 427
Query: 639 PSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKEN 460
SG GKST + L++R Y +G V +D +++ +N+ LRE + +VSQEPVLF +I EN
Sbjct: 428 NSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAEN 487
Query: 459 FLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAIL 280
+G N + EI++A+K ANA+ F+ + P DTLVGERGAQLSGGQKQRIAIARA++
Sbjct: 488 IRYG-RENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALV 546
Query: 279 RNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKV 100
RNPK+LLLDEATSALD++SE VVQ ALD A + +T+V+AHRLSTV NAD IA +G +
Sbjct: 547 RNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVI 606
Query: 99 AEQGTHEELLRKRSIYWRLV--QKQGIQVE 16
E+G H+EL++++ IY++LV Q G +VE
Sbjct: 607 VEKGNHDELMKEKGIYFKLVTMQTAGNEVE 636
>gi|4505771|ref|NP_000434.1| ATP-binding cassette, subfamily B, member
4 isoform A; P glycoprotein 3/multiple drug resistance 3;
P-glycoprotein-3/multiple drug resistance-3; multiple
drug resistance 3 [Homo sapiens]
gi|126932|sp|P21439|MDR3_HUMAN Multidrug resistance protein 3
(P-glycoprotein 3)
gi|72473|pir||DVHU3 multidrug resistance protein 3 - human
gi|307181|gb|AAA36207.1| P-glycoprotein
Length = 1279
Score = 737 bits (1903), Expect = 0.0
Identities = 440/1232 (35%), Positives = 679/1232 (54%), Gaps = 21/1232 (1%)
Frame = -1
Query: 3663 EKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFESD 3484
+KL LG + +I G P GE + V + + L + K+ E +
Sbjct: 53 DKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEE 112
Query: 3483 MNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMSTGH 3304
M R + +G ++Q S +R+++ +LR++I +FD T
Sbjct: 113 MTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTE 172
Query: 3303 LSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGL 3124
L+ L D++ + E +K+ + + F G I+ F W+L S + LS
Sbjct: 173 LNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAA 232
Query: 3123 LDSWGKMKN--NEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYA 2950
+ W K+ + ++K+ + AG++A +ALG +TV + GQ +E+ERY + L+N ++
Sbjct: 233 V--WAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIG 290
Query: 2949 LNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEA 2770
+ +A ++S + A + ++G+ ++ G + + + IL G++ +G+A
Sbjct: 291 IKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQA 350
Query: 2769 ILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPTRPDV 2593
I A+A I DI+ D++ D F K D+ +G + F +V FSYP+R +V
Sbjct: 351 APCIDAFANARGAAYVIFDII-DNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANV 409
Query: 2592 PVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLR 2413
+LK ++ VQ G+ +ALVG+SG GKST +QL+ Y+ D G I+IDG DI N N+ LR
Sbjct: 410 KILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLR 469
Query: 2412 QAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGER 2233
+ +GVV QEPVLF+T+I ENI +G+ + T EI A+K ANA++F+ P T+VGER
Sbjct: 470 EIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGER 529
Query: 2232 GAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAH 2053
GAQLSGGQKQRIAIAR LVRNP+ILLLDEATSALD ESE VQ AL KA GRTTIV+AH
Sbjct: 530 GAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAH 589
Query: 2052 RLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQ-----TQLMSTNYEKMNEN- 1891
RLST+RNA+ I E G IVE G H +L+ GVY LV +Q+ S +E +E
Sbjct: 590 RLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKA 649
Query: 1890 ---------EERVTRQSSHSDFPSNEISHQKIDQEDDYVKKLIAEIKEEGAKKSNICEII 1738
+ R+ R S+ + ++++ + +D E D ++ + + + +++
Sbjct: 650 ATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPV--------SFLKVL 701
Query: 1737 KYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEM-LSKSHFWALSILFL 1561
K ++E+ + + + G P S + + + D + K + ++L LFL
Sbjct: 702 KLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFL 761
Query: 1560 AFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADS 1381
F Q + FGK E L+ +LRSM+FK ++ +++DD ++ LS RL D+
Sbjct: 762 GIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDA 821
Query: 1380 SNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQA 1201
+ V A RL + + + +I+SF Y W+++L +L P++ ++G +
Sbjct: 822 AQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGN 881
Query: 1200 VEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTAN 1021
+ D E + + A EA+EN+RTV +L E + + L + ++A I G
Sbjct: 882 AKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITF 941
Query: 1020 GFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAI 841
+ + +F YA F+FG +L++ + D LV + A G A ++ PD+ KA
Sbjct: 942 SISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAK 1001
Query: 840 HAAGLIFHLFTYPAIMPYDSSQGKRNIK-NGEIELKNVSFEYAQRSDKMILDGVSLKLPA 664
+A +F LF ++ S +G + K G I V F Y R++ +L G+SL++
Sbjct: 1002 LSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKK 1061
Query: 663 GRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVL 484
G+TLALVG SG GKST++ LLERFY + G V +D + +N+ LR + +VSQEP+L
Sbjct: 1062 GQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPIL 1121
Query: 483 FNCSIKENFLFG-ISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQ 307
F+CSI EN +G S SQ EI A K AN F+ P +T VG++G QLSGGQKQ
Sbjct: 1122 FDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQ 1181
Query: 306 RIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADS 127
RIAIARA++R P++LLLDEATSALD++SEKVVQ ALD A E + +V+AHRLST+ NAD
Sbjct: 1182 RIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADL 1241
Query: 126 IAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
I V +NG+V E GTH++LL ++ IY+ +V Q
Sbjct: 1242 IVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ 1273
Score = 326 bits (835), Expect = 3e-87
Identities = 211/586 (36%), Positives = 319/586 (54%), Gaps = 6/586 (1%)
Frame = -1
Query: 3651 FFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFESDMNRV 3472
F +G V +I G QP S E + +A+ + N
Sbjct: 711 FVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVK----------------QQKCNIF 754
Query: 3471 VLLFFLVGF-AYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGM--STGHL 3301
L+F +G ++FTF FLQ G+ +R +LR+D+S+FD STG L
Sbjct: 755 SLIFLFLGIISFFTF-FLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGAL 813
Query: 3300 SIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLL 3121
S L + + + ++ALI + + G I++F W+L I +SG++
Sbjct: 814 STRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIV 873
Query: 3120 DSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNR 2941
+ N ++ + + AG IA +A+ +TV SL +++ Y E+L + ++ +
Sbjct: 874 EMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQK 933
Query: 2940 AFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEAILH 2761
A ++ ++ S F FGA +I G + V+ + I+FG+ LG A
Sbjct: 934 AHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSF 993
Query: 2760 ISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPTRPDVPVL 2584
A A L+ +L + D + E +K D F+G I+F V+F+YPTR +VPVL
Sbjct: 994 APDYAKA-KLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVL 1052
Query: 2583 KEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAM 2404
+ +S V+ G+ +ALVG+SG GKSTV+QLL +Y+ +G + +DG + +N++ LR +
Sbjct: 1053 QGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQL 1112
Query: 2403 GVVFQEPVLFNTSIEENIRFGKPD--ATEQEIIDALKNANAFDFVCNFPDGIKTIVGERG 2230
G+V QEP+LF+ SI ENI +G ++ EI+ A K AN F+ P +T VG++G
Sbjct: 1113 GIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKG 1172
Query: 2229 AQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHR 2050
QLSGGQKQRIAIAR L+R P+ILLLDEATSALD ESE +VQEAL KA GRT IV+AHR
Sbjct: 1173 TQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHR 1232
Query: 2049 LSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTN 1912
LSTI+NA+ I+V + G + E G H+QL+A G+Y ++V Q + N
Sbjct: 1233 LSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQN 1278
>gi|22775296|gb|AAN07779.1| multidrug resistance p-glycoprotein
[Macaca mulatta]
Length = 1283
Score = 737 bits (1903), Expect = 0.0
Identities = 441/1234 (35%), Positives = 664/1234 (53%), Gaps = 23/1234 (1%)
Frame = -1
Query: 3663 EKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNA-------INNKTIDPVDLAHA 3505
+KL +G++ +I+ G P G+ + N NN +
Sbjct: 47 DKLYMVVGILAAIIHGAGLPLMMLVFGDMTDTFANAGNLGDLGALLFNNTNSSNITDTVP 106
Query: 3504 YKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYF 3325
E DM R + +G ++Q S + +R+Q+ ++R++I +F
Sbjct: 107 VMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWF 166
Query: 3324 DGMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSF 3145
D G L+ L D++ + E +KI + + F G I+ F W+L + +
Sbjct: 167 DVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTL--VILAI 224
Query: 3144 GIVLSGLLDSWGKMKNNEKQNEHIS--NAGSIAFQALGCYKTVSSLNGQQQEVERYTEEL 2971
VL +W K+ ++ E ++ AG++A + L +TV + GQ++E+ERY + L
Sbjct: 225 SPVLGVSAAAWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNL 284
Query: 2970 KNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFG 2791
+ ++ + +A ++S A + A + ++G ++ G V+ + + +L G
Sbjct: 285 EEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSKEYSIGQVLTVFFSVLIG 344
Query: 2790 SYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFS 2614
++ +G+A I A+A I I+ D+ + D + K D +G + F+NV FS
Sbjct: 345 AFSVGQASPSIEAFANARGAAFEIFKII-DNKPSIDSYSKSGHKPDNIKGNLEFRNVHFS 403
Query: 2613 YPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYN 2434
YP+R +V +LK ++ VQ G+ +ALVG SG GKST +QL+ Y+ G +S+DG DI
Sbjct: 404 YPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRT 463
Query: 2433 INIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGI 2254
IN++ LR+ +GVV QEPVLF T+I ENIR+G+ D T EI A+K ANA+DF+ P
Sbjct: 464 INVRFLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPQKF 523
Query: 2253 KTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGR 2074
T+VGERGAQLSGGQKQRIAIAR LVRNP+ILLLDEATSALD ESE +VQ AL KA GR
Sbjct: 524 DTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGR 583
Query: 2073 TTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNE 1894
TTIV+AHRLST+RNA+ I + G IVE G+H +L+ G+Y LV Q E N
Sbjct: 584 TTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEIELENA 643
Query: 1893 NEE--------RVTRQSSHSDFPSNEISHQKIDQEDDYVKKL-IAEIKEEGAKKSNICEI 1741
+E ++ S S + + + +KL E +E + I
Sbjct: 644 ADESKSEIDTLEMSSHDSGSSLIRKRSTRRSVRGSQGQDRKLSTKEALDESIPPVSFWRI 703
Query: 1740 IKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWALSILFL 1561
+K +E+ + V + I G P + + K + + D + + S+LFL
Sbjct: 704 MKLNLTEWPYFVVGVFCAIINGGLQPAFAVIFSKIIGIFTRNDDAETKRQNSNLFSLLFL 763
Query: 1560 AFTRPIFI--FFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNA 1387
FI F Q + FGK E L+ +LR M F+ ++ +++DDP +T L+ RL
Sbjct: 764 VLGIVSFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLAN 823
Query: 1386 DSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVD 1207
D++ V A+ RL + + + +I+S Y W+++L +L P++ +AG +
Sbjct: 824 DAAQVKGAIGSRLAIITQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLS 883
Query: 1206 QAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGT 1027
+D E + + A EA+EN RTV +L E + + LQ + ++A I G
Sbjct: 884 GQALKDKKELEGAGKIATEAIENFRTVVSLTQEQKFEHMYDQSLQVPYRNSLRKAHIFGI 943
Query: 1026 ANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRK 847
F + +F YA F+FG +LV + D LV + A G ++ PD+ K
Sbjct: 944 TFSFTQAMMYFSYAGCFRFGAYLVAHSLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAK 1003
Query: 846 A-IHAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKL 670
A + AA +I + P I Y + K N G + V F Y R D +L G+SL++
Sbjct: 1004 AKVSAAHIIMIIEKTPLIDSYSTEGLKPNTLEGNVTFNEVVFNYPTRLDIPVLQGLSLEV 1063
Query: 669 PAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEP 490
G+TLALVG SG GKST++ LLERFY + G+V +D + + +N+ LR + +VSQEP
Sbjct: 1064 KKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKQLNVQWLRAHLGIVSQEP 1123
Query: 489 VLFNCSIKENFLFG-ISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQ 313
+LF+CSI EN +G S SQ EI +A K AN +F+ P T VG++G QLSGGQ
Sbjct: 1124 ILFDCSISENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTRVGDKGTQLSGGQ 1183
Query: 312 KQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNA 133
KQRIAIARA++R P +LLLDEATSALD++SEKVVQ ALD A E + +V+AHRLST+ NA
Sbjct: 1184 KQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNA 1243
Query: 132 DSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
D I V +NG+V E GTH++LL ++ IY+ +V Q
Sbjct: 1244 DLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ 1277
>gi|45361353|ref|NP_989254.1| hypothetical protein MGC76216 [Xenopus
tropicalis]
gi|39645391|gb|AAH63924.1| Hypothetical protein MGC76216 [Xenopus
tropicalis]
Length = 1261
Score = 736 bits (1900), Expect = 0.0
Identities = 444/1229 (36%), Positives = 685/1229 (55%), Gaps = 19/1229 (1%)
Frame = -1
Query: 3654 LFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFESDMNR 3475
L +G + +I G C P + GE S + +++ N + +K E ++ +
Sbjct: 53 LMIIGTLGAIGCGSCYPLMNVVFGEMSDSFLCHNSSLQNSSA-----CAKFKPIEEEIQK 107
Query: 3474 VVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMSTGHLSI 3295
L + +GFA G+LQ S +R+ + +L ++I +FD +G L+
Sbjct: 108 FSLYYAGLGFAVLFCGYLQVSCWVVAASRQTRKMRKAFFHSVLSQEIGWFDVTKSGDLNT 167
Query: 3294 VLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLLDS 3115
L +N+ + + +K+A T V G ++ W+LA S + L+ + S
Sbjct: 168 RLTENINKINDGIGDKVAHFFQNTTICVSGILIGLIQGWKLALVILATSPVLTLASAMFS 227
Query: 3114 WGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKN----GEKYAL 2947
+ K+ + AG++A + L +TV + G+++E++RYTE LK G K ++
Sbjct: 228 RIVVSLTTKELAAYAKAGAVAQEVLSSIRTVVAFGGEEKEIKRYTENLKQAKDIGIKKSI 287
Query: 2946 NRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGT-IEPGVVVRILYYILFGSYCLGEA 2770
F L A ++ T + F ++G ++ E G V+ + + + F SY +G+A
Sbjct: 288 ASQFALGLVNGA-FYATYGVGF---WYGTTLVLEDDDYTIGDVMAVFFNVSFSSYAIGQA 343
Query: 2769 ILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPTRPDV 2593
H A I ++ S ++ D F ++ K D +G I K++ FSYP+RP V
Sbjct: 344 ASHFEAFHIARAAASSIFKVIKQS-SSIDNFSNDGFKPDNIKGNIELKDIYFSYPSRPGV 402
Query: 2592 PVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLR 2413
VL ++ +V+ G+ +ALVG SG GKST++QLL Y+ G +++DG+DI ++N+ R
Sbjct: 403 KVLNGLNLSVKSGQTVALVGQSGCGKSTIVQLLQRLYDPKEGTLAVDGHDIKSLNVTYYR 462
Query: 2412 QAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGER 2233
+ +GVV QEPVLF T+I++NIR+G+ D T++EI A+K ANA+DF+ PD +T+VGER
Sbjct: 463 ELIGVVSQEPVLFGTTIKQNIRYGRDDVTDEEIEKAVKEANAYDFIMALPDKYETLVGER 522
Query: 2232 GAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAH 2053
GAQLSGGQKQRIA+AR LVRNP+ILLLDEATSALD SE +VQ AL KA GRTTIVVAH
Sbjct: 523 GAQLSGGQKQRIAVARALVRNPKILLLDEATSALDTGSEAVVQAALDKARKGRTTIVVAH 582
Query: 2052 RLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNL--VQTQLMSTNYEKMNENEERV 1879
RLSTI A+ I+V++ G + E G H +L+ G+Y +L QT +S + E +N+ +
Sbjct: 583 RLSTIWTADVIVVIDNGAVAEQGTHSELMEKKGIYFSLATAQTVQLSDDNETTEKNQNGI 642
Query: 1878 --TRQSSHSDFPSNEISHQKIDQEDDYVKKLIAEIKEEGAKKS----NICEIIKYCRSEY 1717
+ S F S KI +++D +EE +KK + +++K RSE+
Sbjct: 643 IYEKASLIQRFNSQTSLKSKILEDED---------EEEESKKDLPTVSFFQLLKLNRSEW 693
Query: 1716 CILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWALSILFLAFTRPIFI 1537
+ + ++ + + G PL + +A + E + K L L T + +
Sbjct: 694 PYILLGIIAAGVIGSLLPLFCIFYARIIAVFASNDPETIRKES--DLCSLIFGLTGVVIL 751
Query: 1536 ---FFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTA 1366
+ Y FG++ E L+++LR M+FK ++ A++DD + L+ RL D+S +
Sbjct: 752 LAYIARGYMFGRSGETLTMRLRHMAFKAMIQQDIAWFDDKDNNTGALTTRLATDASEIQT 811
Query: 1365 AVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDS 1186
A RLG + L+ I+L VI++F Y W+++L L P + + G + + D
Sbjct: 812 ATGYRLGFLAENLIGIVLTVIIAFVYGWELALLGLAMAPFMVICGLLEFSALTGFATRDK 871
Query: 1185 IAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACS 1006
+++ + A EA++N+RT+ +L E + + LQK + ++A I G +
Sbjct: 872 KQLQRAGKIATEAVDNIRTLVSLTRERTFEEMYSESLQKPYRNSLRKAQIYGLYFAIGHA 931
Query: 1005 CYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGL 826
Y+F +A F FG +L+ E I + LV ++ A G+ + + PD+ KA AA
Sbjct: 932 FYYFTHAALFCFGAYLIKYERINVEEALLVFSVITFGAMTLGTTLTFAPDYAKATSAARY 991
Query: 825 IFHLFTYPAIMPYDSSQG-KRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLA 649
+F LF + S QG K + +G +E +NVSF Y RSD +L + +K+ +G+T+A
Sbjct: 992 LFALFESKPAIDSSSQQGQKPDCFSGSLEFRNVSFNYPTRSDVRVLRDLCVKVESGQTVA 1051
Query: 648 LVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSI 469
VG SG GKST + LL+RFY +GEV +D+ + N+ LR + +VSQEPVLF+CSI
Sbjct: 1052 FVGSSGCGKSTSVQLLQRFYDPKEGEVLLDDVDAKCFNVQWLRSQMGIVSQEPVLFDCSI 1111
Query: 468 KENFLFG-ISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIA 292
EN +G S S EI A K AN SF+ P +TLVG +G QLSGGQKQRIAIA
Sbjct: 1112 AENIAYGDNSRTVSMDEIQSAAKAANIHSFIEGLPLKYETLVGAKGTQLSGGQKQRIAIA 1171
Query: 291 RAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLK 112
RA++R PK+LLLDEATSALD++SEKVVQ ALD A + + +++AHRL+TV NAD I V+
Sbjct: 1172 RALIRAPKILLLDEATSALDNESEKVVQQALDQARKGRTCILIAHRLTTVQNADIIVVMN 1231
Query: 111 NGKVAEQGTHEELLRKRSIYWRLVQKQGI 25
GK+ E G+H+ELL K Y+ LV Q I
Sbjct: 1232 KGKIIEHGSHQELLAKCGAYYDLVNAQAI 1260
Score = 324 bits (831), Expect = 9e-87
Identities = 202/585 (34%), Positives = 319/585 (54%), Gaps = 20/585 (3%)
Frame = -1
Query: 1713 ILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKS------------HFWALSI 1570
++ I LG+ G YPL + + + +++ + + S ++L
Sbjct: 53 LMIIGTLGAIGCGSCYPLMNVVFGEMSDSFLCHNSSLQNSSACAKFKPIEEEIQKFSLYY 112
Query: 1569 LFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLN 1390
L F + Q + A + + K+R F ++S ++D + L+ RL
Sbjct: 113 AGLGFAVLFCGYLQVSCWVVAASRQTRKMRKAFFHSVLSQEIGWFD--VTKSGDLNTRLT 170
Query: 1389 ADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFV 1210
+ + + + D++ + +++ WK++L +L P+L LA V
Sbjct: 171 ENINKINDGIGDKVAHFFQNTTICVSGILIGLIQGWKLALVILATSPVLTLASAMFSRIV 230
Query: 1209 DQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQG 1030
++ A+ K+ A E L ++RTV A E + I T +L++ ++ K+++
Sbjct: 231 VSLTTKELAAYAKAGAVAQEVLSSIRTVVAFGGEEKEIKRYTENLKQAKDIGIKKSIASQ 290
Query: 1029 TANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLV--LMTLSMTASYAGSAVAYLPD 856
A G ++ Y V F +GT LVL + D Y + +M + S++ A+
Sbjct: 291 FALGLVNGAFYATYGVGFWYGTTLVLED-----DDYTIGDVMAVFFNVSFSSYAIGQAAS 345
Query: 855 HRKAIH----AAGLIFHLFTYPAIMPYDSSQGKR--NIKNGEIELKNVSFEYAQRSDKMI 694
H +A H AA IF + + + S+ G + NIK G IELK++ F Y R +
Sbjct: 346 HFEAFHIARAAASSIFKVIKQSSSIDNFSNDGFKPDNIK-GNIELKDIYFSYPSRPGVKV 404
Query: 693 LDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRES 514
L+G++L + +G+T+ALVG SG GKSTI+ LL+R Y +G + +D ++ +N+ + RE
Sbjct: 405 LNGLNLSVKSGQTVALVGQSGCGKSTIVQLLQRLYDPKEGTLAVDGHDIKSLNVTYYREL 464
Query: 513 VSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERG 334
+ +VSQEPVLF +IK+N +G + + EI++A+K ANA+ F+ P +TLVGERG
Sbjct: 465 IGVVSQEPVLFGTTIKQNIRYG-RDDVTDEEIEKAVKEANAYDFIMALPDKYETLVGERG 523
Query: 333 AQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHR 154
AQLSGGQKQRIA+ARA++RNPK+LLLDEATSALD+ SE VVQ ALD A + +T+VVAHR
Sbjct: 524 AQLSGGQKQRIAVARALVRNPKILLLDEATSALDTGSEAVVQAALDKARKGRTTIVVAHR 583
Query: 153 LSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQV 19
LST+ AD I V+ NG VAEQGTH EL+ K+ IY+ L Q +Q+
Sbjct: 584 LSTIWTADVIVVIDNGAVAEQGTHSELMEKKGIYFSLATAQTVQL 628
>gi|31442763|gb|AAN07780.2| multidrug resistance p-glycoprotein
[Macaca fascicularis]
Length = 1283
Score = 734 bits (1896), Expect = 0.0
Identities = 442/1234 (35%), Positives = 663/1234 (52%), Gaps = 23/1234 (1%)
Frame = -1
Query: 3663 EKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNA-------INNKTIDPVDLAHA 3505
+KL +G + +I+ G P G+ + N NN +
Sbjct: 47 DKLYMVVGTLAAIIHGAGLPLMMLVFGDMTDTFANAGNLGDLGALLFNNTNSSNITDTVP 106
Query: 3504 YKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYF 3325
E DM R + +G ++Q S + +R+Q+ ++R++I +F
Sbjct: 107 VMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWF 166
Query: 3324 DGMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSF 3145
D G L+ L D++ + E +KI + + F G I+ F W+L S
Sbjct: 167 DVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISP 226
Query: 3144 GIVLSGLLDSWGKMKNNEKQNEHIS--NAGSIAFQALGCYKTVSSLNGQQQEVERYTEEL 2971
+ LS + W K+ ++ E ++ AG++A + L +TV + GQ++E+ERY + L
Sbjct: 227 VLGLSAAV--WAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNL 284
Query: 2970 KNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFG 2791
+ ++ + +A ++S A + A + ++G ++ G V+ + + +L G
Sbjct: 285 EEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSKEYSIGQVLTVFFSVLIG 344
Query: 2790 SYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFS 2614
++ +G+A I A+A I I+ D+ + D + K D +G + F+NV FS
Sbjct: 345 AFSVGQASPSIEAFANARGAAFEIFKII-DNKPSIDSYSKSGHKPDNIKGNLEFRNVHFS 403
Query: 2613 YPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYN 2434
YP+R +V +LK ++ VQ G+ +ALVG SG GKST +QL+ Y+ G +S+DG DI
Sbjct: 404 YPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRT 463
Query: 2433 INIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGI 2254
IN++ LR+ +GVV QEPVLF T+I ENIR+G+ D T EI A+K ANA+DF+ P
Sbjct: 464 INVRFLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPQKF 523
Query: 2253 KTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGR 2074
T+VGERGAQLSGGQKQRIAIAR LVRNP+ILLLDEATSALD ESE +VQ AL KA GR
Sbjct: 524 DTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGR 583
Query: 2073 TTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNE 1894
TTIV+AHRLST+RNA+ I + G IVE G+H +L+ G+Y LV Q E N
Sbjct: 584 TTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEIELENA 643
Query: 1893 NEE--------RVTRQSSHSDFPSNEISHQKIDQEDDYVKKL-IAEIKEEGAKKSNICEI 1741
+E ++ S S + + + +KL E +E + I
Sbjct: 644 ADESKSEIDTLEMSSHDSGSSLIRKRSTRRSVRGSQGQDRKLSTKEALDESIPPVSFWRI 703
Query: 1740 IKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWALSILFL 1561
+K +E+ + V + I G P + + K + + D + + S+LFL
Sbjct: 704 MKLNLTEWPYFVVGVFCAIINGGLQPAFAVIFSKIIGIFTRNDDAETKRQNSNLFSLLFL 763
Query: 1560 AFTRPIFI--FFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNA 1387
FI F Q + FGK E L+ +LR M F+ ++ +++DDP +T L+ RL
Sbjct: 764 VLGIVSFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLAN 823
Query: 1386 DSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVD 1207
D++ V A+ RL + + + +I+S Y W+++L +L P++ +AG +
Sbjct: 824 DAAQVKGAIGSRLAIITQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLS 883
Query: 1206 QAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGT 1027
+D E + + A EA+EN RTV +L E + + LQ + ++A I G
Sbjct: 884 GQALKDKKELEGAGKIATEAIENFRTVVSLTQEQKFEHMYDQSLQVPYRNSLRKAHIFGI 943
Query: 1026 ANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRK 847
F + +F YA F+FG +LV + D LV + A G ++ PD+ K
Sbjct: 944 TFSFTQAMMYFSYAGCFRFGAYLVAHSLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAK 1003
Query: 846 A-IHAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKL 670
A + AA +I + P I Y + K N G + V F Y R D +L G+SL++
Sbjct: 1004 AKVSAAHIIMIIEKTPLIDSYSTEGLKPNTLEGNVTFNEVVFNYPTRLDIPVLQGLSLEV 1063
Query: 669 PAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEP 490
G+TLALVG SG GKST++ LLERFY + G+V +D + + +N+ LR + +VSQEP
Sbjct: 1064 KKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKQLNVQWLRAHLGIVSQEP 1123
Query: 489 VLFNCSIKENFLFG-ISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQ 313
+LF+CSI EN +G S SQ EI +A K AN +F+ P T VG++G QLSGGQ
Sbjct: 1124 ILFDCSISENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTRVGDKGTQLSGGQ 1183
Query: 312 KQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNA 133
KQRIAIARA++R P +LLLDEATSALD++SEKVVQ ALD A E + +V+AHRLST+ NA
Sbjct: 1184 KQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNA 1243
Query: 132 DSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
D I V +NG+V E GTH++LL ++ IY+ +V Q
Sbjct: 1244 DLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ 1277
>gi|126930|sp|P23174|MDR3_CRIGR Multidrug resistance protein 3
(P-glycoprotein 3)
gi|2119778|pir||I48123 p-glycoprotein isoform III - Chinese hamster
gi|191169|gb|AAA68885.1| p-glycoprotein isoform III
Length = 1281
Score = 733 bits (1893), Expect = 0.0
Identities = 439/1234 (35%), Positives = 677/1234 (54%), Gaps = 23/1234 (1%)
Frame = -1
Query: 3663 EKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFESD 3484
+KL LG + +I G P GE + V + + + + ++ E +
Sbjct: 53 DKLFMLLGTIMAIAHGSGLPLMMIVFGEMTDKFVNNAGNFSLPVNFSLSMINPGRILEEE 112
Query: 3483 MNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMSTGH 3304
M R + +G ++Q S +R+ + +LR+++ +FD T
Sbjct: 113 MTRYAYYYSGLGGGVLVAAYIQVSFWTLAAGRQIKKIRQNFFHAILRQEMGWFDIKGTTE 172
Query: 3303 LSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGL 3124
L+ L D++ + E +K+ + + F G I+ F W+L S + LS
Sbjct: 173 LNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAA 232
Query: 3123 LDSWGKMKN--NEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYA 2950
+ W K+ + ++K+ + AG++A +ALG +TV + GQ +E+ERY + L+N +K
Sbjct: 233 V--WAKILSTFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKKIG 290
Query: 2949 LNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEA 2770
+ +A ++S + A + ++G+ ++ G + + + IL G++ +G+A
Sbjct: 291 IKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQA 350
Query: 2769 ILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPTRPDV 2593
I A+A I DI+ D++ D F K D+ +G + F +V FSYP+R ++
Sbjct: 351 APCIDAFANARGAAYVIFDII-DNNPKIDSFSERGHKPDSIKGNLDFSDVHFSYPSRANI 409
Query: 2592 PVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLR 2413
+LK ++ VQ G+ +ALVG SG GK+T +QLL Y+ G ISIDG DI N N++ LR
Sbjct: 410 KILKGLNLKVQSGQTVALVGNSGCGKTTTLQLLQRLYDPTEGTISIDGQDIRNFNVRYLR 469
Query: 2412 QAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGER 2233
+ +GVV QEPVLF+T+I ENIR+G+ + T +EI A+K ANA++F+ P T+VGER
Sbjct: 470 EIIGVVSQEPVLFSTTIAENIRYGRGNVTMEEIKKAVKEANAYEFIMKLPQKFDTLVGER 529
Query: 2232 GAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAH 2053
GAQLSGGQKQRIAIAR LVRNP+ILLLDEATSALD ESE VQ AL KA GRTTIV+AH
Sbjct: 530 GAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAH 589
Query: 2052 RLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQ-----TQLMSTNYE-KMNEN 1891
RLST+RNA+ I E G IVE G H +L+ GVY LV +Q++S +E +++E
Sbjct: 590 RLSTVRNADVIAGFEDGVIVEQGSHSELMQKEGVYFKLVNMQTSGSQILSQEFEVELSEE 649
Query: 1890 -----------EERVTRQSSHSDFPSNEISHQKIDQEDDYVKKLIAEIKEEGAKKSNICE 1744
+ + R S+ S+ H ++D + D + + + + +
Sbjct: 650 KAADGMTPNGWKSHIFRNSTKKSLKSSRAHHHRLDVDADELDANVPPV--------SFLK 701
Query: 1743 IIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEM-LSKSHFWALSIL 1567
++K ++E+ + + + + G P S ++ + + D + K + ++L L
Sbjct: 702 VLKLNKTEWPYFVVGTVCAIVNGALQPAISIILSEMIAIFGPGDDAVKQQKCNLFSLVFL 761
Query: 1566 FLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNA 1387
L F Q + FGK E L+ +LRSM+FK ++ +++DD ++ LS RL
Sbjct: 762 GLGVLSFFTFFLQGFTFGKAGEILTTRLRSMAFKAMLRQDMSWFDDYKNSTGALSTRLAT 821
Query: 1386 DSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVD 1207
D + V A RL + + +I+SF Y W+++L +L P + ++G +
Sbjct: 822 DRAQVQGATGTRLALIAQNTANLGTGIIISFIYGWQLTLLLLSVVPFIAVSGIVEMKMLA 881
Query: 1206 QAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGT 1027
+ D A E + + A EA+EN+RTV +L E + + L + + + A I G
Sbjct: 882 GNAKRDKKALEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLHEPYRNSVQMAHIYGI 941
Query: 1026 ANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRK 847
+ + +F YA F+FG +L++ + D LV + A G A ++ PD+ K
Sbjct: 942 TFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAK 1001
Query: 846 AIHAAGLIFHLFTYPAIMPYDSSQGKRNIK-NGEIELKNVSFEYAQRSDKMILDGVSLKL 670
A +A +F LF ++ S +G K G + V F Y R++ +L G+SL++
Sbjct: 1002 AKLSAAHLFSLFERQPLIDSYSGEGLWPDKFEGSVTFNEVVFNYPTRANMPVLQGLSLEV 1061
Query: 669 PAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEP 490
G+TLALVG SG GKST++ LLERFY + G V +D + +N+ LR + +VSQEP
Sbjct: 1062 KKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVLLDGQEAKKLNIQWLRAQLGIVSQEP 1121
Query: 489 VLFNCSIKENFLFG-ISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQ 313
VLF+CSI EN +G S SQ EI +A K AN F+ PQ T VG++G QLSGGQ
Sbjct: 1122 VLFDCSIAENIAYGDNSRVVSQDEIVRAAKAANIHPFIETLPQKYKTRVGDKGTQLSGGQ 1181
Query: 312 KQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNA 133
KQR+AI RA++R P+VLLLDEATSALD++SEKVVQ ALD A E + +V+AHRLST+ NA
Sbjct: 1182 KQRLAIRRALIRQPRVLLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNA 1241
Query: 132 DSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
D I V++NGKV E GTH++LL ++ IY+ +V Q
Sbjct: 1242 DLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVNIQ 1275
Score = 322 bits (824), Expect = 6e-86
Identities = 210/586 (35%), Positives = 318/586 (53%), Gaps = 6/586 (1%)
Frame = -1
Query: 3651 FFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFESDMNRV 3472
F +G V +I+ G QP S L E + +A+ + N
Sbjct: 713 FVVGTVCAIVNGALQPAISIILSEMIAIFGPGDDAVK----------------QQKCNLF 756
Query: 3471 VLLFFLVG-FAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGM--STGHL 3301
L+F +G ++FTF FLQ G+ +R +LR+D+S+FD STG L
Sbjct: 757 SLVFLGLGVLSFFTF-FLQGFTFGKAGEILTTRLRSMAFKAMLRQDMSWFDDYKNSTGAL 815
Query: 3300 SIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLL 3121
S L + + + ++ALI + G I++F W+L I +SG++
Sbjct: 816 STRLATDRAQVQGATGTRLALIAQNTANLGTGIIISFIYGWQLTLLLLSVVPFIAVSGIV 875
Query: 3120 DSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNR 2941
+ N ++ + + AG IA +A+ +TV SL +++ Y E+L + ++
Sbjct: 876 EMKMLAGNAKRDKKALEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLHEPYRNSVQM 935
Query: 2940 AFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEAILH 2761
A ++ ++ S F FGA +I G + V+ + I+FG+ LG A
Sbjct: 936 AHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSF 995
Query: 2760 ISRLASAIPLTVPIADILLDSDATADEFFSEEI-KDTFQGIISFKNVLFSYPTRPDVPVL 2584
A A L+ L + D + E + D F+G ++F V+F+YPTR ++PVL
Sbjct: 996 APDYAKA-KLSAAHLFSLFERQPLIDSYSGEGLWPDKFEGSVTFNEVVFNYPTRANMPVL 1054
Query: 2583 KEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAM 2404
+ +S V+ G+ +ALVG+SG GKSTV+QLL +Y+ +G + +DG + +NI+ LR +
Sbjct: 1055 QGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVLLDGQEAKKLNIQWLRAQL 1114
Query: 2403 GVVFQEPVLFNTSIEENIRFGKPD--ATEQEIIDALKNANAFDFVCNFPDGIKTIVGERG 2230
G+V QEPVLF+ SI ENI +G ++ EI+ A K AN F+ P KT VG++G
Sbjct: 1115 GIVSQEPVLFDCSIAENIAYGDNSRVVSQDEIVRAAKAANIHPFIETLPQKYKTRVGDKG 1174
Query: 2229 AQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHR 2050
QLSGGQKQR+AI R L+R PR+LLLDEATSALD ESE +VQEAL KA GRT IV+AHR
Sbjct: 1175 TQLSGGQKQRLAIRRALIRQPRVLLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHR 1234
Query: 2049 LSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTN 1912
LSTI+NA+ I+V++ G++ E G H+QL+A G+Y ++V Q + N
Sbjct: 1235 LSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVNIQAGAQN 1280
>gi|46394984|gb|AAS91648.1| multidrug resistance protein;
P-glycoprotein [Macaca mulatta]
Length = 1283
Score = 733 bits (1893), Expect = 0.0
Identities = 440/1234 (35%), Positives = 661/1234 (52%), Gaps = 23/1234 (1%)
Frame = -1
Query: 3663 EKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNA-------INNKTIDPVDLAHA 3505
+KL +G + +I+ G P G+ + N NN +
Sbjct: 47 DKLYMVVGTLAAIIHGAGLPLMMLVFGDMTDTFANAGNLGDLGALLFNNTNSSNITDTVP 106
Query: 3504 YKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYF 3325
E DM R + +G ++Q S + +R+Q+ ++R++I +F
Sbjct: 107 VMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWF 166
Query: 3324 DGMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSF 3145
D G L+ L D + + E +KI + + F G I+ F W+L + +
Sbjct: 167 DVHDVGELNTRLTDEVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTL--VILAI 224
Query: 3144 GIVLSGLLDSWGKMKNNEKQNEHIS--NAGSIAFQALGCYKTVSSLNGQQQEVERYTEEL 2971
+L +W K+ ++ E ++ AG +A + L +TV + GQ++E+ERY + L
Sbjct: 225 SPILGLSAAAWAKILSSFTDKELLAYAKAGVVAEEVLAAIRTVIAFGGQKKELERYNKNL 284
Query: 2970 KNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFG 2791
+ ++ + +A ++S A + A + ++G ++ G V+ + + +L G
Sbjct: 285 EEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSKEYSIGQVLTVFFSVLIG 344
Query: 2790 SYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFS 2614
++ +G+A I A+A I I+ D+ + D + K D +G + F+NV FS
Sbjct: 345 AFSVGQASPSIEAFANARGAAFEIFKII-DNKPSIDSYSKSGHKPDNIKGNLEFRNVHFS 403
Query: 2613 YPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYN 2434
YP+R +V +LK ++ VQ G+ +ALVG SG GKST +QL+ Y+ G +S+DG DI
Sbjct: 404 YPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRT 463
Query: 2433 INIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGI 2254
IN++ LR+ +GVV QEPVLF T+I ENIR+G+ D T EI A+K ANA+DF+ P
Sbjct: 464 INVRFLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPQKF 523
Query: 2253 KTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGR 2074
T+VGERGAQLSGGQKQRIAIAR LVRNP+ILLLDEATSALD ESE +VQ AL KA GR
Sbjct: 524 DTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGR 583
Query: 2073 TTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNE 1894
TTIV+AHRLST+RNA+ I + G IVE G+H +L+ G+Y LV Q E N
Sbjct: 584 TTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEIELENA 643
Query: 1893 NEE--------RVTRQSSHSDFPSNEISHQKIDQEDDYVKKL-IAEIKEEGAKKSNICEI 1741
+E ++ S S + + + +KL E +E + I
Sbjct: 644 ADESKSEIDTLEMSSHDSGSSLIRKRSTRRSVRGSQGQDRKLSTKEALDESIPPVSFWRI 703
Query: 1740 IKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWALSILFL 1561
+K +E+ + V + I G P + + K + + D + + S+LFL
Sbjct: 704 MKLNLTEWPYFVVGVFCAIINGGLQPAFAVIFSKIIGIFTRNDDAETKQQNSNLFSLLFL 763
Query: 1560 AFTRPIFI--FFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNA 1387
FI F Q + FGK E L+ +LR M F+ ++ +++DDP +T L+ RL
Sbjct: 764 VLGIVSFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLAN 823
Query: 1386 DSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVD 1207
D++ V A+ RL + + + +I+S Y W+++L +L P++ +AG +
Sbjct: 824 DAAQVKGAIGSRLAIITQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLS 883
Query: 1206 QAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGT 1027
+D E + + A EA+EN RTV +L E + + LQ + ++A I G
Sbjct: 884 GQALKDKKELEGAGKIATEAIENFRTVVSLTQEQKFEHMYDQSLQVPYRNSLRKAHIFGI 943
Query: 1026 ANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRK 847
F + +F YA F+FG +LV + D LV + A G ++ PD+ K
Sbjct: 944 TFSFTQAMMYFSYAGCFRFGAYLVAHSLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAK 1003
Query: 846 A-IHAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKL 670
A + AA +I + P I Y + K N G + V F Y R D +L G+SL++
Sbjct: 1004 AKVSAAHIIMIIEKTPLIDSYSTEGLKPNTLEGNVTFNEVVFNYPTRLDIPVLQGLSLEV 1063
Query: 669 PAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEP 490
G+TLALVG SG GKST++ LLERFY + G+V +D + + +N+ LR + +VSQEP
Sbjct: 1064 KKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKQLNVQWLRAHLGIVSQEP 1123
Query: 489 VLFNCSIKENFLFG-ISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQ 313
+LF+CSI EN +G S SQ EI +A K AN +F+ P T VG++G QLSGGQ
Sbjct: 1124 ILFDCSISENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTRVGDKGTQLSGGQ 1183
Query: 312 KQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNA 133
KQRIAIARA++R P +LLLDEATSALD++SEKVVQ ALD A E + +V+AHRLST+ NA
Sbjct: 1184 KQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNA 1243
Query: 132 DSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
D I V +NG+V E GTH++LL ++ IY+ +V Q
Sbjct: 1244 DLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ 1277
>gi|46394982|gb|AAS91647.1| multidrug resistance protein 1;
P-glycoprotein [Canis familiaris]
Length = 1281
Score = 733 bits (1892), Expect = 0.0
Identities = 443/1234 (35%), Positives = 661/1234 (52%), Gaps = 23/1234 (1%)
Frame = -1
Query: 3663 EKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPV-------DLAHA 3505
++L +G + +I+ G P G + NKT + + H
Sbjct: 47 DRLYMLVGTMAAIIHGAALPLMMLVFGNMTDSFANA-GISRNKTFPVIINESITNNTQHF 105
Query: 3504 YKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYF 3325
E +M + +G ++Q S +R+Q+ ++R++I +F
Sbjct: 106 INHLEEEMTTYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQILKIRKQFFHAIMRQEIGWF 165
Query: 3324 DGMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSF 3145
D G L+ L D++ + E +KI + + F G I+ F W+L S
Sbjct: 166 DVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSIATFFTGFIVGFTRGWKLTLVILAISP 225
Query: 3144 GIVLSGLLDSWGKMKNNEKQNEHIS--NAGSIAFQALGCYKTVSSLNGQQQEVERYTEEL 2971
+ LS + W K+ ++ E ++ AG++A + L +TV + GQ++E+ERY + L
Sbjct: 226 VLGLSAAI--WAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNL 283
Query: 2970 KNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFG 2791
+ ++ + +A ++S A + A + ++G +++ G V+ + + +L G
Sbjct: 284 EEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTSLVLSSEYSIGQVLTVFFSVLIG 343
Query: 2790 SYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFS 2614
++ +G+A I A+A I I+ D+ + D + K D +G + FKNV FS
Sbjct: 344 AFSIGQASPSIEAFANARGAAYEIFKII-DNKPSIDSYSKSGHKPDNIKGNLEFKNVHFS 402
Query: 2613 YPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYN 2434
YP+R +V +LK ++ VQ G+ +ALVG SG GKST +QL+ Y+ G + IDG DI
Sbjct: 403 YPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTDGMVCIDGQDIRT 462
Query: 2433 INIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGI 2254
IN++ LR+ GVV QEPVLF T+I ENIR+G+ + T EI A+K ANA+DF+ P+
Sbjct: 463 INVRHLREITGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPNKF 522
Query: 2253 KTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGR 2074
T+VGERGAQLSGGQKQRIAIAR LVRNP+ILLLDEATSALD ESE +VQ AL KA GR
Sbjct: 523 DTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGR 582
Query: 2073 TTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNE 1894
TTIV+AHRLST+RNA+ I + G IVE G+H +L+ G+Y LV Q E N
Sbjct: 583 TTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTRGNEIELENA 642
Query: 1893 NEE--------RVTRQSSHSDFPSNEISHQKIDQEDDYVKKL-IAEIKEEGAKKSNICEI 1741
E ++ + S S + + I +KL E E + I
Sbjct: 643 TGESKSESDALEMSPKDSGSSLIKRRSTRRSIHAPQGQDRKLGTKEDLNENVPPVSFWRI 702
Query: 1740 IKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWALSILFL 1561
+K +E+ + + + I G P S + + + D+D + + S+LFL
Sbjct: 703 LKLNSTEWPYFVVGIFCAIINGGLQPAFSIIFSRIIGIFTRDEDPETKRQNSNMFSVLFL 762
Query: 1560 AFTRPIFI--FFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNA 1387
FI F Q + FGK E L+ +LR M F+ ++ +++DDP +T L+ RL
Sbjct: 763 VLGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLAN 822
Query: 1386 DSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVD 1207
D++ V A+ RL + + + +I+S Y W+++L +L P++ +AG +
Sbjct: 823 DAAQVKGAIGSRLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLS 882
Query: 1206 QAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGT 1027
+D E + + A EA+EN RTV +L E + + LQ + ++A I G
Sbjct: 883 GQALKDKKELEGAGKIATEAIENFRTVVSLTREQKFEYMYAQSLQVPYRNSLRKAHIFGV 942
Query: 1026 ANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRK 847
+ + +F YA F+FG +LV E + D LV + A G ++ PD+ K
Sbjct: 943 SFSITQAMMYFSYAGCFRFGAYLVANEFMNFQDVLLVFSAIVFGAMAVGQVSSFAPDYAK 1002
Query: 846 A-IHAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKL 670
A + AA +I + P I Y K N G + V F Y R D +L G+SL++
Sbjct: 1003 AKVSAAHVIMIIEKSPLIDSYSPHGLKPNTLEGNVTFNEVVFNYPTRPDIPVLQGLSLEV 1062
Query: 669 PAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEP 490
G+TLALVG SG GKST++ LLERFY + G V ID + + +N+ LR + +VSQEP
Sbjct: 1063 KKGQTLALVGSSGCGKSTVVQLLERFYDPLAGSVLIDGKEIKHLNVQWLRAHLGIVSQEP 1122
Query: 489 VLFNCSIKENFLFG-ISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQ 313
+LF+CSI EN +G S S EI QA K AN F+ P+ +T VG++G QLSGGQ
Sbjct: 1123 ILFDCSIAENIAYGDNSRVVSHEEIVQAAKEANIHHFIETLPEKYNTRVGDKGTQLSGGQ 1182
Query: 312 KQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNA 133
KQRIAIARA++R P +LLLDEATSALD++SEKVVQ ALD A E + +V+AHRLST+ NA
Sbjct: 1183 KQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNA 1242
Query: 132 DSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
D I V +NGKV E GTH++LL ++ IY+ +V Q
Sbjct: 1243 DLIVVFQNGKVKEHGTHQQLLAQKGIYFSMVSVQ 1276
>gi|8926217|gb|AAF81747.1| his-tagged-multidrug resistance
glycoprotein MDR1 [synthetic construct]
Length = 1287
Score = 733 bits (1891), Expect = 0.0
Identities = 442/1234 (35%), Positives = 661/1234 (52%), Gaps = 23/1234 (1%)
Frame = -1
Query: 3663 EKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPV-------DLAHA 3505
++L +G + +I+ G P G + NKT + + H
Sbjct: 53 DRLYMLVGTMAAIIHGAALPLMMLVFGNMTDSFANA-GISRNKTFPVIINESITNNTQHF 111
Query: 3504 YKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYF 3325
E +M + +G ++Q S +R+Q+ ++R++I +F
Sbjct: 112 INHLEEEMTTYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQILKIRKQFFHAIMRQEIGWF 171
Query: 3324 DGMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSF 3145
D G L+ L D++ + E +KI + + F G I+ F W+L S
Sbjct: 172 DVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSIATFFTGFIVGFTRGWKLTLVILAISP 231
Query: 3144 GIVLSGLLDSWGKMKNNEKQNEHIS--NAGSIAFQALGCYKTVSSLNGQQQEVERYTEEL 2971
+ LS + W K+ ++ E ++ AG++A + L +TV + GQ++E+ERY + L
Sbjct: 232 VLGLSAAI--WAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNL 289
Query: 2970 KNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFG 2791
+ ++ + +A ++S A + A + ++G +++ G V+ + + +L G
Sbjct: 290 EEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTSLVLSSEYSIGQVLTVFFSVLIG 349
Query: 2790 SYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFS 2614
++ +G+A I A+A I I+ D+ + D + K D +G + FKNV FS
Sbjct: 350 AFSIGQASPSIEAFANARGAAYEIFKII-DNKPSIDSYSKSGHKPDNIKGNLEFKNVHFS 408
Query: 2613 YPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYN 2434
YP+R +V +LK ++ VQ G+ +ALVG SG GKST +QL+ Y+ G + IDG DI
Sbjct: 409 YPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTDGMVCIDGQDIRT 468
Query: 2433 INIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGI 2254
IN++ LR+ GVV QEPVLF T+I ENIR+G+ + T EI A+K ANA+DF+ P+
Sbjct: 469 INVRHLREITGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPNKF 528
Query: 2253 KTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGR 2074
T+VGERGAQLSGGQKQRIAIAR LVRNP+ILLLDEATSALD ESE +VQ AL KA GR
Sbjct: 529 DTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGR 588
Query: 2073 TTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNE 1894
TTIV+AHRLST+RNA+ I + G IVE G+H +L+ G+Y LV Q E N
Sbjct: 589 TTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTRGNEIELENA 648
Query: 1893 NEE--------RVTRQSSHSDFPSNEISHQKIDQEDDYVKKL-IAEIKEEGAKKSNICEI 1741
E ++ + S S + + I +KL E E + I
Sbjct: 649 TGESKSESDALEMSPKDSGSSLIKRRSTRRSIHAPQGQDRKLGTKEDLNENVPPVSFWRI 708
Query: 1740 IKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWALSILFL 1561
+K +E+ + + + I G P S + + + D+D + + S+LFL
Sbjct: 709 LKLNSTEWPYFVVGIFCAIINGGLQPAFSIIFSRIIGIFTRDEDPETKRQNSNMFSVLFL 768
Query: 1560 AFTRPIFI--FFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNA 1387
FI F Q + FGK E L+ +LR M F+ ++ +++DDP +T L+ RL
Sbjct: 769 VLGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLAN 828
Query: 1386 DSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVD 1207
D++ V A+ RL + + + +I+S Y W+++L +L P++ +AG +
Sbjct: 829 DAAQVKGAIGSRLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLS 888
Query: 1206 QAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGT 1027
+D E + + A EA+EN RTV +L E + + LQ + ++A I G
Sbjct: 889 GQALKDKKELEGAGKIATEAIENFRTVVSLTREQKFEYMYAQSLQVPYRNSLRKAHIFGV 948
Query: 1026 ANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRK 847
+ + +F YA F+FG +LV E + D LV + A G ++ PD+ K
Sbjct: 949 SFSITQAMMYFSYAGCFRFGAYLVANEFMNFQDVLLVFSAIVFGAMAVGQVSSFAPDYAK 1008
Query: 846 A-IHAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKL 670
A + AA +I + P I Y K N G + V F Y R D +L G+SL++
Sbjct: 1009 AKVSAAHVIMIIEKSPLIDSYSPHGLKPNTLEGNVTFNEVVFNYPTRPDIPVLQGLSLEV 1068
Query: 669 PAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEP 490
G+TLALVG SG GKST++ LLERFY + G V ID + + +N+ LR + +VSQEP
Sbjct: 1069 KKGQTLALVGSSGCGKSTVVQLLERFYDPLAGSVLIDGKEIKHLNVQWLRAHLGIVSQEP 1128
Query: 489 VLFNCSIKENFLFG-ISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQ 313
+LF+CSI EN +G S S EI QA K AN F+ P+ +T VG++G QLSGGQ
Sbjct: 1129 ILFDCSIAENIAYGDNSRVVSHEEIMQAAKEANIHHFIETLPEKYNTRVGDKGTQLSGGQ 1188
Query: 312 KQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNA 133
KQRIAIARA++R P +LLLDEATSALD++SEKVVQ ALD A E + +V+AHRLST+ NA
Sbjct: 1189 KQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNA 1248
Query: 132 DSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
D I V +NGKV E GTH++LL ++ IY+ ++ Q
Sbjct: 1249 DLIVVFQNGKVKEHGTHQQLLAQKGIYFSMISVQ 1282
>gi|2353264|gb|AAB69423.1| P-glycoprotein [Homo sapiens]
Length = 1279
Score = 733 bits (1891), Expect = 0.0
Identities = 445/1234 (36%), Positives = 669/1234 (54%), Gaps = 23/1234 (1%)
Frame = -1
Query: 3663 EKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVK-------VTNAINNKTIDPVDLAHA 3505
+KL +G + +I+ G P GE + + ++N N I+
Sbjct: 47 DKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDINDTGF--- 103
Query: 3504 YKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYF 3325
+ E DM R + +G ++Q S + +R+Q+ ++R++I +F
Sbjct: 104 FMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWF 163
Query: 3324 DGMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSF 3145
D G L+ L D++ + E +KI + + F G I+ F W+L S
Sbjct: 164 DVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISP 223
Query: 3144 GIVLSGLLDSWGKMKNNEKQNEHIS--NAGSIAFQALGCYKTVSSLNGQQQEVERYTEEL 2971
+ LS + W K+ ++ E ++ AG++A + L +TV + GQ++E+ERY + L
Sbjct: 224 VLGLSAAV--WAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNL 281
Query: 2970 KNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFG 2791
+ ++ + +A ++S A + A + ++G ++ G G V+ + + +L G
Sbjct: 282 EEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTV-FSVLIG 340
Query: 2790 SYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFS 2614
++ +G+A I A+A I I+ D+ + D + K D +G + F+NV FS
Sbjct: 341 AFSVGQASPSIEAFANARGAAYEIFKII-DNKPSIDSYSKSGHKPDNIKGNLEFRNVHFS 399
Query: 2613 YPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYN 2434
YP+R +V +LK ++ VQ G+ +ALVG SG GKST +QL+ Y+ G +S+DG DI
Sbjct: 400 YPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRT 459
Query: 2433 INIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGI 2254
IN++ LR+ +GVV QEPVLF T+I ENIR+G+ + T EI A+K ANA+DF+ P
Sbjct: 460 INVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKF 519
Query: 2253 KTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGR 2074
T+VGERGAQLSGGQKQRIAIAR LVRNP+ILLLDEATSALD ESE +VQ AL KA GR
Sbjct: 520 DTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGR 579
Query: 2073 TTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNE 1894
TTIV+AHRLST+RNA+ I + G IVE G+H +L+ G+Y LV Q E N
Sbjct: 580 TTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENA 639
Query: 1893 NEE--------RVTRQSSHSDFPSNEISHQKIDQEDDYVKKL-IAEIKEEGAKKSNICEI 1741
+E ++ S S + + + +KL E +E + I
Sbjct: 640 ADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRI 699
Query: 1740 IKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWALSILFL 1561
+K +E+ + V + I G P + + K + D + + S+LFL
Sbjct: 700 MKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFL 759
Query: 1560 AFTRPIFI--FFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNA 1387
A FI F Q + FGK E L+ +LR M F+ ++ +++DDP +T L+ RL
Sbjct: 760 ALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLAN 819
Query: 1386 DSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVD 1207
D++ V A+ RL + + + +I+SF Y W+++L +L P++ +AG +
Sbjct: 820 DAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLS 879
Query: 1206 QAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGT 1027
+D E + + A EA+EN RTV +L E + + LQ + ++A I G
Sbjct: 880 GQALKDKKELEGAGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGI 939
Query: 1026 ANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRK 847
F + +F YA F+FG +LV + + D LV + A G ++ PD+ K
Sbjct: 940 TFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAK 999
Query: 846 A-IHAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKL 670
A I AA +I + P I Y + N G + V F Y R D +L G+SL++
Sbjct: 1000 AKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEV 1059
Query: 669 PAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEP 490
G+TLALVG SG GKST++ LLERFY + G+V +D + + +N+ LR + +VSQEP
Sbjct: 1060 KKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEP 1119
Query: 489 VLFNCSIKENFLFG-ISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQ 313
+LF+CSI EN +G S SQ EI +A K AN +F+ P T VG++G QLSGGQ
Sbjct: 1120 ILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQ 1179
Query: 312 KQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNA 133
KQRIAIARA++R P +LLLDEATSALD++SEKVVQ ALD A E + +V+AHRLST+ NA
Sbjct: 1180 KQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNA 1239
Query: 132 DSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
D I V +NG+V E GTH++LL ++ IY+ +V Q
Sbjct: 1240 DLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ 1273
Score = 328 bits (840), Expect = 8e-88
Identities = 194/510 (38%), Positives = 295/510 (57%), Gaps = 3/510 (0%)
Frame = -1
Query: 1536 FFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVD 1357
+ Q F+ A + K+R F +M ++D H L+ RL D S + +
Sbjct: 130 YIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFD--VHDVGELNTRLTDDVSKINEGIG 187
Query: 1356 DRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAF 1177
D++G ++ I+ F WK++L +L P+L L+ + +++ +A+
Sbjct: 188 DKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAY 247
Query: 1176 EKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYF 997
K+ A E L +RTV A + + + +L++ + K+A+ + G A +
Sbjct: 248 AKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIY 307
Query: 996 FIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFH 817
YA++F +GT LVL E + L + ++ + A G A + A AA IF
Sbjct: 308 ASYALAFWYGTTLVLSGEY-SIGQVLTVFSVLIGAFSVGQASPSIEAFANARGAAYEIFK 366
Query: 816 LF-TYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVG 640
+ P+I Y S K + G +E +NV F Y R + IL G++LK+ +G+T+ALVG
Sbjct: 367 IIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVG 426
Query: 639 PSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKEN 460
SG GKST + L++R Y +G V +D +++ +N+ LRE + +VSQEPVLF +I EN
Sbjct: 427 NSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAEN 486
Query: 459 FLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAIL 280
+G N + EI++A+K ANA+ F+ + P DTLVGERGAQLSGGQKQRIAIARA++
Sbjct: 487 IRYG-RENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALV 545
Query: 279 RNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKV 100
RNPK+LLLDEATSALD++SE VVQ ALD A + +T+V+AHRLSTV NAD IA +G +
Sbjct: 546 RNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVI 605
Query: 99 AEQGTHEELLRKRSIYWRLV--QKQGIQVE 16
E+G H+EL++++ IY++LV Q G +VE
Sbjct: 606 VEKGNHDELMKEKGIYFKLVTMQTAGNEVE 635
>gi|2149087|gb|AAB58489.1| multidrug resistance protein-1 [Ovis aries]
Length = 1285
Score = 732 bits (1890), Expect = 0.0
Identities = 443/1235 (35%), Positives = 671/1235 (53%), Gaps = 24/1235 (1%)
Frame = -1
Query: 3663 EKLLFFLGVVFSILTGMCQPFESYTLGETSQVL--------VKVTNAINNKTIDPVDLAH 3508
++L LG + +I+ G P G+ + + ++N N TID +
Sbjct: 51 DRLCMVLGTLAAIIHGAGLPLMMLVFGDMTDSFAGAGNLGNITLSNISNTSTIDRTEYG- 109
Query: 3507 AYKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISY 3328
K E +M + +G ++Q S + +R+Q+ +++++I +
Sbjct: 110 --KKLEKEMTTYAYYYSGIGAGVLIAAYIQVSFWCLAAGRQVHRIRKQFFHAIMQQEIGW 167
Query: 3327 FDGMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFS 3148
FD G L+ L +++ + E +KI + + F G I+ F T W L + +
Sbjct: 168 FDVHDVGKLNTRLTNDVSKINEGIGDKIGMFFQAMATFFTGFIIGFTTGWNLTL--VILA 225
Query: 3147 FGIVLSGLLDSWGKMKNN--EKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEE 2974
VL W K+ ++ +K+ + AG++A + L KTV + GQ++E+ERY +
Sbjct: 226 IIPVLGLSAAIWAKILSSFTDKKLLAYAKAGAVAEEVLAAIKTVIAFGGQKKELERYNKN 285
Query: 2973 LKNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILF 2794
L+ ++ + +A ++S A + A + ++G +++ G V+ + + +L
Sbjct: 286 LEEAKRIGIKKAITANISMGAAFLLIYASYALAFWYGTSLVLSREYSIGQVLTVFFSVLI 345
Query: 2793 GSYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLF 2617
G++ +G+A +I A+A + I+ D+ + D + + K D +G + F+NV F
Sbjct: 346 GAFSIGQASPNIEAFANARGAAYEVFKII-DNKPSIDSYSNTGHKPDNIKGNLEFRNVHF 404
Query: 2616 SYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIY 2437
YP+R +V +LK ++ V G+ +ALVG SG GKST +QL+ Y+ G +SIDG DI
Sbjct: 405 HYPSRNEVKILKGLNLKVGSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSIDGQDIR 464
Query: 2436 NINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDG 2257
IN++ LR+ +GVV QEPVLF T+I ENIR+G+ D T EI A+K ANA+DF+ P+
Sbjct: 465 TINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIQKAVKEANAYDFIMKLPNK 524
Query: 2256 IKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIG 2077
T+VGERGAQLSGGQKQRIAIAR LVRNP+ILLLDEATSAL ESE +VQ AL KA G
Sbjct: 525 FDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALGTESEAVVQAALDKARKG 584
Query: 2076 RTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMN 1897
RTTIV+AHRLST+RNA+ I ++ G IVE G H +L+ G+Y LV Q E N
Sbjct: 585 RTTIVIAHRLSTVRNADIIAGLDDGVIVEEGSHDELMGKRGIYFKLVTMQTKGNELELEN 644
Query: 1896 ENEERVTR--------QSSHSDFPSNEISHQKIDQEDDYVKKL-IAEIKEEGAKKSNICE 1744
E +++ Q S S + + + I +KL E +E +
Sbjct: 645 TPGESLSKTDDLYMSSQDSRSSLIRRKSTRRSIRGSQSQDRKLSTEETLDESVPPVSFWR 704
Query: 1743 IIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYA-FDKDE-MLSKSHFWALSI 1570
I+K +E+ + V + I G P S + + + D DE S+ ++L
Sbjct: 705 ILKLNITEWPYFVVGVFCAIINGALQPAFSVIFSRIIGIFTRNDNDETKRQNSNLFSLLF 764
Query: 1569 LFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLN 1390
L L I F Q + FGK E L+ +LR + F+ ++ +++DDP +T L+ RL
Sbjct: 765 LILGIISFITFFLQGFTFGKAGEILTRRLRYLVFRSMLRQDVSWFDDPKNTTGALTTRLA 824
Query: 1389 ADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFV 1210
D++ V AV RL + + + +I+S Y W+++L +L P++ +AG +
Sbjct: 825 NDAAQVKGAVGSRLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAVAGVIEMKML 884
Query: 1209 DQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQG 1030
+D E + + A EA+EN RTV +L E R + LQ + +RA + G
Sbjct: 885 SGQALKDKKELEGAGKIATEAIENFRTVVSLTREERFEYMYAQSLQVPYRNSLRRAHVFG 944
Query: 1029 TANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHR 850
+ +F YA F+FG +LV + + D LV + A G + PD+
Sbjct: 945 ITFSITQAMMYFSYAGCFRFGAYLVAQGIMEFQDVLLVFSAVVFGAMAVGQVSTFAPDYA 1004
Query: 849 KA-IHAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLK 673
KA + AA +I + P I Y + K + G + +V F Y R D +L G+SL+
Sbjct: 1005 KAKVSAAHVINIIEKIPLIDSYSTEGLKPSTVEGSVAFNDVVFNYPTRPDVPVLRGLSLE 1064
Query: 672 LPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQE 493
+ G+TLALVG SG GKST++ LLERFY + G V ID + V +N+ LR + +VSQE
Sbjct: 1065 VKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFIDGKEVKQLNVQWLRAHMGIVSQE 1124
Query: 492 PVLFNCSIKENFLFG-ISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGG 316
P+LF+CSI EN +G S SQ EI+ A K AN SF+ P +T VG++G QLSGG
Sbjct: 1125 PILFDCSIGENIAYGDNSRVVSQEEIEHAAKEANIHSFIEMLPDKYNTRVGDKGTQLSGG 1184
Query: 315 QKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVN 136
QKQRIAIARA++R P +LLLDEATSALD++SEKVVQ ALD A E + +V+AHRLST+ N
Sbjct: 1185 QKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQN 1244
Query: 135 ADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
AD I V +NG++ E GTH++LL ++ IY+ +V Q
Sbjct: 1245 ADLIVVFQNGRIKEHGTHQQLLAQKGIYFTMVSVQ 1279
>gi|2852441|gb|AAC02113.1| multidrug resistance p-glycoprotein [Canis
familiaris]
Length = 1280
Score = 731 bits (1886), Expect = 0.0
Identities = 440/1234 (35%), Positives = 661/1234 (52%), Gaps = 23/1234 (1%)
Frame = -1
Query: 3663 EKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPV-------DLAHA 3505
++L +G + +I+ G P G + NKT + + H
Sbjct: 46 DRLYMLVGTMAAIIHGAALPLMMLVFGNMTDSFANA-GISRNKTFPVIINESITNNTQHF 104
Query: 3504 YKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYF 3325
E +M + +G ++Q S +R+Q+ ++R++I +F
Sbjct: 105 INHLEEEMTTYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQILKIRKQFFHAIMRQEIGWF 164
Query: 3324 DGMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSF 3145
D G L+ L D++ + E +K+ + + F G I+ F W+L S
Sbjct: 165 DVHDVGELNTRLTDDVSKINEGIGDKVGMFFQSIATFFTGFIVGFTPGWKLTLVILAISP 224
Query: 3144 GIVLSGLLDSWGKMKNNEKQNEHIS--NAGSIAFQALGCYKTVSSLNGQQQEVERYTEEL 2971
+ LS + W K+ ++ E ++ AG++A + L +TV + GQ++E+ERY + L
Sbjct: 225 VLGLSAAI--WAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNL 282
Query: 2970 KNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFG 2791
+ ++ + +A ++S A + A + ++G +++ G V+ + + +L G
Sbjct: 283 EEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTSLVLSSEYTIGQVLTVFFSVLIG 342
Query: 2790 SYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFS 2614
++ +G+A I A+A I I+ D+ + D + K D +G + FKNV FS
Sbjct: 343 AFSIGQASPSIEAFANARGAAYEIFKII-DNKPSIDSYSKSGHKPDNIKGNLEFKNVHFS 401
Query: 2613 YPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYN 2434
YP+R +V +LK ++ VQ G+ +ALVG SG GKST +QL+ Y+ G + IDG DI
Sbjct: 402 YPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTDGMVCIDGQDIRT 461
Query: 2433 INIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGI 2254
IN++ LR+ GVV QEPVLF T+I ENIR+G+ + T EI A+K ANA+DF+ P+
Sbjct: 462 INVRHLREITGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPNKF 521
Query: 2253 KTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGR 2074
T+VGERGA+LSGGQKQRIAIAR LVRNP+ILLLDEATSALD ESE +VQ AL KA GR
Sbjct: 522 DTLVGERGARLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGR 581
Query: 2073 TTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNE 1894
TTIV+AHRLST+RNA+ I + G IVE G+H +L+ G+Y LV Q E N
Sbjct: 582 TTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTRGNEIELENA 641
Query: 1893 NEE--------RVTRQSSHSDFPSNEISHQKIDQEDDYVKKL-IAEIKEEGAKKSNICEI 1741
E ++ + S S + + I +KL E E + I
Sbjct: 642 TGESKSESDALEMSPKDSGSSLIKRRSTRRSIHAPQGQDRKLGTKEDLNENVPSVSFWRI 701
Query: 1740 IKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWALSILFL 1561
+K +E+ + + + I G P S + + + D+D + + S+LFL
Sbjct: 702 LKLNSTEWPYFVVGIFCAIINGGLQPAFSIIFSRIIGIFTRDEDPETKRQNSNMFSVLFL 761
Query: 1560 AFTRPIFI--FFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNA 1387
FI F Q + FGK E L+ +LR M F+ ++ +++DDP +T L+ RL
Sbjct: 762 VLGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLAN 821
Query: 1386 DSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVD 1207
D++ V A+ RL + + + +I+S Y W+++L +L P++ +AG +
Sbjct: 822 DAAQVKGAIGSRLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLS 881
Query: 1206 QAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGT 1027
+D E + + A EA+EN RTV +L E + + LQ + ++A I G
Sbjct: 882 GQALKDKKELEGAGKIATEAIENFRTVVSLTREQKFEYMYAQSLQVPYRNSLRKAHIFGV 941
Query: 1026 ANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRK 847
+ + +F YA F+FG +LV E + D LV + A G ++ PD+ K
Sbjct: 942 SFSITQAMMYFSYAGCFRFGAYLVANEFMNFQDVLLVFSAIVFGAMAVGQVSSFAPDYAK 1001
Query: 846 A-IHAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKL 670
A + AA +I + P I Y K N G + V F Y R D +L G+SL++
Sbjct: 1002 AKVSAAHVIMIIEKSPLIDSYSPHGLKPNTLEGNVTFNEVVFNYPTRPDIPVLQGLSLEV 1061
Query: 669 PAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEP 490
G+TLALVG SG GKST++ LLERFY + G V ID + + +N+ LR + +VSQEP
Sbjct: 1062 KKGQTLALVGSSGCGKSTVVQLLERFYDPLAGSVLIDGKEIKHLNVQWLRAHLGIVSQEP 1121
Query: 489 VLFNCSIKENFLFG-ISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQ 313
+LF+CSI EN +G S S EI QA K AN F+ P+ +T VG++G QLSGGQ
Sbjct: 1122 ILFDCSIAENIAYGDNSRVVSHEEIMQAAKEANIHHFIETLPEKYNTRVGDKGTQLSGGQ 1181
Query: 312 KQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNA 133
KQRIAIARA++R P +LLLDEATSALD++SEKVVQ ALD A E + +V+AHRLST+ NA
Sbjct: 1182 KQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNA 1241
Query: 132 DSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
D I V +NGKV E GTH++LL ++ IY+ ++ Q
Sbjct: 1242 DLIVVFQNGKVKEHGTHQQLLAQKGIYFSMISVQ 1275
>gi|22759019|gb|AAN05645.1| multidrug resistance p-glycoprotein [Canis
familiaris]
Length = 1281
Score = 730 bits (1885), Expect = 0.0
Identities = 444/1234 (35%), Positives = 662/1234 (52%), Gaps = 23/1234 (1%)
Frame = -1
Query: 3663 EKLLFFLGVVFSILTGMCQPFESYTLGETSQVLV-------KVTNAINNKTIDPVDLAHA 3505
++L +G + +I+ G P G + K I N++I + H
Sbjct: 47 DRLYMLVGTMAAIIHGAALPLMMLVFGNMTDSFANAGISRNKAFPVIINESITN-NTQHF 105
Query: 3504 YKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYF 3325
E +M + +G ++Q S +R+Q+ ++R++I +F
Sbjct: 106 INHLEEEMTTYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQILKIRKQFFHAIMRQEIGWF 165
Query: 3324 DGMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSF 3145
D G L+ L D++ + E +KI + + F G I+ F W+L S
Sbjct: 166 DVHDVGELNTRLTDDVSKINEGIGDKIGMFFHSIATFFTGFIVGFTRGWKLTLVILAISP 225
Query: 3144 GIVLSGLLDSWGKMKNNEKQNEHIS--NAGSIAFQALGCYKTVSSLNGQQQEVERYTEEL 2971
+ LS + W K+ ++ E ++ AG++A + L +TV + GQ++E+ERY + L
Sbjct: 226 VLGLSAAI--WAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNL 283
Query: 2970 KNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFG 2791
+ + + +A ++S A + A + ++G +++ G V+ + + +L G
Sbjct: 284 EEAKGIGIKKAITANISIGAAFLLIYASYALAFWYGTSLVLSSEYSIGQVLTVFFSVLIG 343
Query: 2790 SYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFS 2614
++ +G+A I A+A I I+ D+ + D + K D +G + FKNV FS
Sbjct: 344 AFSIGQASPSIEAFANARGAAYEIFKII-DNKPSIDSYSKSGHKPDNIKGNLEFKNVHFS 402
Query: 2613 YPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYN 2434
YP+R +V +LK ++ VQ G+ +ALVG SG GKST +QL+ Y+ G + IDG DI
Sbjct: 403 YPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTDGMVCIDGQDIRT 462
Query: 2433 INIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGI 2254
IN++ LR+ GVV QEPVLF T+I ENIR+G+ + T EI A+K ANA+DF+ P+
Sbjct: 463 INVRHLREITGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPNKF 522
Query: 2253 KTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGR 2074
T+VGERGAQLSGGQKQRIAIAR LVRNP+ILLLDEATSALD ESE +VQ AL KA GR
Sbjct: 523 DTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGR 582
Query: 2073 TTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNE 1894
TTIV+AHRLST+RNA+ I + G IVE G+H +L+ G+Y LV Q E N
Sbjct: 583 TTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTRGNEIELENA 642
Query: 1893 NEE--------RVTRQSSHSDFPSNEISHQKIDQEDDYVKKL-IAEIKEEGAKKSNICEI 1741
E ++ + S S + + I +KL E E + I
Sbjct: 643 TGESKSESDALEMSPKDSGSSLIKRRSTRRSIHAPQGQDRKLGTKEDLNENVPPVSFWRI 702
Query: 1740 IKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWALSILFL 1561
+K +E+ + + + I G P S + + + D+D + + S+LFL
Sbjct: 703 LKLNSTEWPYFVVGIFCAIINGGLQPAFSIIFSRIIGIFTRDEDPETKRQNSNMFSVLFL 762
Query: 1560 AFTRPIFI--FFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNA 1387
FI F Q + FGK E L+ +LR M F+ ++ +++DDP +T L+ RL
Sbjct: 763 VLGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLAN 822
Query: 1386 DSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVD 1207
D++ V A+ RL + + + +I+S Y W+++L +L P++ +AG +
Sbjct: 823 DAAQVKGAIGSRLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLS 882
Query: 1206 QAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGT 1027
+D E + + A EA+EN RTV +L E + + LQ + ++A I G
Sbjct: 883 GQALKDKKELEGAGKIATEAIENFRTVVSLTREQKFEYMYAQSLQVPYRNSLRKAHIFGV 942
Query: 1026 ANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRK 847
+ + +F YA F+FG +LV E + D LV + A G ++ PD+ K
Sbjct: 943 SFSITQAMMYFSYAGCFRFGAYLVANEFMNFQDVLLVFSAIVFGAMAVGQVSSFAPDYAK 1002
Query: 846 A-IHAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKL 670
A + AA +I + P I Y K N G + V F Y R D +L G+SL++
Sbjct: 1003 AKVSAAHVIMIIEKSPLIDSYSPHGLKPNTLEGNVTFNEVVFNYPTRPDIPVLQGLSLEV 1062
Query: 669 PAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEP 490
G+TLALVG SG GKST++ LLERFY + G V ID + + +N+ LR + +VSQEP
Sbjct: 1063 KKGQTLALVGSSGCGKSTVVQLLERFYDPLAGSVLIDGKEIKHLNVQWLRAHLGIVSQEP 1122
Query: 489 VLFNCSIKENFLFG-ISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQ 313
+LF+CSI EN +G S S EI QA K AN F+ P+ +T VG++G QLSGGQ
Sbjct: 1123 ILFDCSIAENIAYGDNSRVVSHEEIMQAAKEANIHHFIETLPEKYNTRVGDKGTQLSGGQ 1182
Query: 312 KQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNA 133
KQRIAIARA++R P +LLLDEATSALD++SEKVVQ ALD A E + +V+AHRLST+ NA
Sbjct: 1183 KQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNA 1242
Query: 132 DSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
D I V +NGKV E GTH++LL ++ IY+ +V Q
Sbjct: 1243 DLIVVFQNGKVKEHGTHQQLLAQKGIYFSMVSVQ 1276
>gi|9961250|ref|NP_061337.1| ATP-binding cassette, subfamily B, member
4 isoform B; P glycoprotein 3/multiple drug resistance 3;
P-glycoprotein-3/multiple drug resistance-3; multiple
drug resistance 3 [Homo sapiens]
Length = 1286
Score = 730 bits (1885), Expect = 0.0
Identities = 440/1239 (35%), Positives = 679/1239 (54%), Gaps = 28/1239 (2%)
Frame = -1
Query: 3663 EKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFESD 3484
+KL LG + +I G P GE + V + + L + K+ E +
Sbjct: 53 DKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEE 112
Query: 3483 MNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMSTGH 3304
M R + +G ++Q S +R+++ +LR++I +FD T
Sbjct: 113 MTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTE 172
Query: 3303 LSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGL 3124
L+ L D++ + E +K+ + + F G I+ F W+L S + LS
Sbjct: 173 LNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAA 232
Query: 3123 LDSWGKMKN--NEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYA 2950
+ W K+ + ++K+ + AG++A +ALG +TV + GQ +E+ERY + L+N ++
Sbjct: 233 V--WAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIG 290
Query: 2949 LNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEA 2770
+ +A ++S + A + ++G+ ++ G + + + IL G++ +G+A
Sbjct: 291 IKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQA 350
Query: 2769 ILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPTRPDV 2593
I A+A I DI+ D++ D F K D+ +G + F +V FSYP+R +V
Sbjct: 351 APCIDAFANARGAAYVIFDII-DNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANV 409
Query: 2592 PVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLR 2413
+LK ++ VQ G+ +ALVG+SG GKST +QL+ Y+ D G I+IDG DI N N+ LR
Sbjct: 410 KILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLR 469
Query: 2412 QAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGER 2233
+ +GVV QEPVLF+T+I ENI +G+ + T EI A+K ANA++F+ P T+VGER
Sbjct: 470 EIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGER 529
Query: 2232 GAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAH 2053
GAQLSGGQKQRIAIAR LVRNP+ILLLDEATSALD ESE VQ AL KA GRTTIV+AH
Sbjct: 530 GAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAH 589
Query: 2052 RLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQ-----TQLMSTNYEKMNEN- 1891
RLST+RNA+ I E G IVE G H +L+ GVY LV +Q+ S +E +E
Sbjct: 590 RLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKA 649
Query: 1890 ---------EERVTRQSSHSDFPSNEISHQKIDQEDDYVKKLIAEIKEEGAKKSNICEII 1738
+ R+ R S+ + ++++ + +D E D ++ + + + +++
Sbjct: 650 ATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPV--------SFLKVL 701
Query: 1737 KYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEM-LSKSHFWALSILFL 1561
K ++E+ + + + G P S + + + D + K + ++L LFL
Sbjct: 702 KLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFL 761
Query: 1560 AFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADS 1381
F Q + FGK E L+ +LRSM+FK ++ +++DD ++ LS RL D+
Sbjct: 762 GIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDA 821
Query: 1380 SNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQA 1201
+ V A RL + + + +I+SF Y W+++L +L P++ ++G +
Sbjct: 822 AQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGN 881
Query: 1200 VEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTAN 1021
+ D E + + A EA+EN+RTV +L E + + L + ++A I G
Sbjct: 882 AKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITF 941
Query: 1020 GFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAI 841
+ + +F YA F+FG +L++ + D LV + A G A ++ PD+ KA
Sbjct: 942 SISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAK 1001
Query: 840 HAAGLIFHLFTYPAIMPYDSSQGKRNIK-NGEIELKNVSFEYAQRSDKMILDGVSLKLPA 664
+A +F LF ++ S +G + K G I V F Y R++ +L G+SL++
Sbjct: 1002 LSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKK 1061
Query: 663 GRTLALVGPSGSGKSTIISLLERFYHAVDGEV-------KIDEENVVDVNLHHLRESVSL 505
G+TLALVG SG GKST++ LLERFY + G V +D + +N+ LR + +
Sbjct: 1062 GQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGI 1121
Query: 504 VSQEPVLFNCSIKENFLFG-ISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQ 328
VSQEP+LF+CSI EN +G S SQ EI A K AN F+ P +T VG++G Q
Sbjct: 1122 VSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQ 1181
Query: 327 LSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLS 148
LSGGQKQRIAIARA++R P++LLLDEATSALD++SEKVVQ ALD A E + +V+AHRLS
Sbjct: 1182 LSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLS 1241
Query: 147 TVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
T+ NAD I V +NG+V E GTH++LL ++ IY+ +V Q
Sbjct: 1242 TIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ 1280
Score = 321 bits (822), Expect = 1e-85
Identities = 212/593 (35%), Positives = 319/593 (53%), Gaps = 13/593 (2%)
Frame = -1
Query: 3651 FFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFESDMNRV 3472
F +G V +I G QP S E + +A+ + N
Sbjct: 711 FVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVK----------------QQKCNIF 754
Query: 3471 VLLFFLVGF-AYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGM--STGHL 3301
L+F +G ++FTF FLQ G+ +R +LR+D+S+FD STG L
Sbjct: 755 SLIFLFLGIISFFTF-FLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGAL 813
Query: 3300 SIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLL 3121
S L + + + ++ALI + + G I++F W+L I +SG++
Sbjct: 814 STRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIV 873
Query: 3120 DSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNR 2941
+ N ++ + + AG IA +A+ +TV SL +++ Y E+L + ++ +
Sbjct: 874 EMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQK 933
Query: 2940 AFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEAILH 2761
A ++ ++ S F FGA +I G + V+ + I+FG+ LG A
Sbjct: 934 AHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSF 993
Query: 2760 ISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPTRPDVPVL 2584
A A L+ +L + D + E +K D F+G I+F V+F+YPTR +VPVL
Sbjct: 994 APDYAKA-KLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVL 1052
Query: 2583 KEISFNVQGGECIALVGASGSGKSTVIQLLLHYYN-------IDSGRISIDGNDIYNINI 2425
+ +S V+ G+ +ALVG+SG GKSTV+QLL +Y+ +D G +DG + +N+
Sbjct: 1053 QGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNV 1112
Query: 2424 KQLRQAMGVVFQEPVLFNTSIEENIRFGKPD--ATEQEIIDALKNANAFDFVCNFPDGIK 2251
+ LR +G+V QEP+LF+ SI ENI +G ++ EI+ A K AN F+ P +
Sbjct: 1113 QWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYE 1172
Query: 2250 TIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRT 2071
T VG++G QLSGGQKQRIAIAR L+R P+ILLLDEATSALD ESE +VQEAL KA GRT
Sbjct: 1173 TRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRT 1232
Query: 2070 TIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTN 1912
IV+AHRLSTI+NA+ I+V + G + E G H+QL+A G+Y ++V Q + N
Sbjct: 1233 CIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQN 1285
>gi|6981354|ref|NP_036822.1| ATP-binding cassette, sub-family B
(MDR/TAP), member 4; ATP-binding cassette, sub-family B
(MDR/TAP), member 4 (P-glycoprotein 3/ multidrug
resistance 2); ATP-binding cassette sub-family B
(MDR/TAP) member 4 (P-glycoprotein 3/ multidrug
resistance 2); P-glycoprotein 3/ multidrug resistance 2;
ATP-binding cassette sub-family B (MDR/TAP) member 4
(P-glycoprotein 3/ multidrug resistance 2 [Rattus
norvegicus]
gi|1170903|sp|Q08201|MDR2_RAT Multidrug resistance protein 2
(P-glycoprotein 2)
gi|543425|pir||S41646 p-glycoprotein - rat
gi|310193|gb|AAA02937.1| P-glycoprotein
Length = 1278
Score = 729 bits (1881), Expect = 0.0
Identities = 436/1234 (35%), Positives = 674/1234 (54%), Gaps = 23/1234 (1%)
Frame = -1
Query: 3663 EKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFESD 3484
+KL LG +I G P GE + V + + + + ++ E +
Sbjct: 50 DKLFMLLGTAMAIAHGSGLPLMMIVFGEMTDKFVDNAGNFSLPVNFSLSMLNPGRILEEE 109
Query: 3483 MNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMSTGH 3304
M R + +G ++Q S +R+++ +LR+++ +FD T
Sbjct: 110 MTRYAYYYSGLGGGVLLAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEMGWFDIKGTTE 169
Query: 3303 LSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGL 3124
L+ L D++ + E +K+ + + F G I+ F W+L + + +L
Sbjct: 170 LNTRLTDDISKISEGIGDKVGMFFQAIATFFAGFIVGFIRGWKLTL--VIMAITAILGLS 227
Query: 3123 LDSWGKMKN--NEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYA 2950
W K+ + ++K+ + AG++A +ALG +TV + GQ +E+ERY + L+N +K
Sbjct: 228 TAVWAKILSTFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKKIG 287
Query: 2949 LNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEA 2770
+ +A ++S + A + ++G+ ++ G + + + IL G++ +G+A
Sbjct: 288 IKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQA 347
Query: 2769 ILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPTRPDV 2593
I +A I DI+ D++ D F K D+ +G + F +V FSYP+R ++
Sbjct: 348 APCIDAFPNARGAAYVIFDII-DNNPKIDSFSERGHKPDSIKGNLEFSDVHFSYPSRANI 406
Query: 2592 PVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLR 2413
+LK ++ V+ G+ +ALVG SG GKST +QLL Y+ G ISIDG DI N N++ LR
Sbjct: 407 KILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGTISIDGQDIRNFNVRCLR 466
Query: 2412 QAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGER 2233
+ +GVV QEPVLF+T+I ENIR+G+ + T EI A+K ANA+DF+ P T+VG+R
Sbjct: 467 EFIGVVSQEPVLFSTTIAENIRYGRGNVTMDEIKKAVKEANAYDFIMKLPQKFDTLVGDR 526
Query: 2232 GAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAH 2053
GAQLSGGQKQRIAIAR LVRNP+ILLLDEATSALD ESE VQ AL KA GRTTIV+AH
Sbjct: 527 GAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAH 586
Query: 2052 RLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQ-----TQLMSTNYEKMNENE 1888
RLST+RNA+ I E G IVE G H +LI G+Y LV +Q++S +E +E
Sbjct: 587 RLSTVRNADVIAGFEDGVIVEQGSHSELIKKEGIYFRLVNMQTSGSQILSEEFEVELSDE 646
Query: 1887 E------------RVTRQSSHSDFPSNEISHQKIDQEDDYVKKLIAEIKEEGAKKSNICE 1744
+ R+ R S+ S+ ++D E + + + + + +
Sbjct: 647 KAAGGVAPNGWKARIFRNSTKKSLKSSRAHQNRLDVETNELDANVPPV--------SFLK 698
Query: 1743 IIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEM-LSKSHFWALSIL 1567
+++ ++E+ + L + G P S ++ + + D + K + ++L L
Sbjct: 699 VLRLNKTEWPYFVVGTLCAIANGALQPAFSIILSEMIAIFGPGDDTVKQQKCNMFSLVFL 758
Query: 1566 FLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNA 1387
L F Q + FGK E L+ +LRSM+FK ++ +++DD ++ LS RL
Sbjct: 759 GLGVHSFFTFFLQGFTFGKAGEILTTRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLAT 818
Query: 1386 DSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVD 1207
D++ V A RL + + +I+SF Y W+++L +L P + +AG +
Sbjct: 819 DAAQVQGATGTRLALIAQNTANLGTGIIISFIYGWQLTLLLLSVVPFIAVAGIVEMKMLA 878
Query: 1206 QAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGT 1027
+ D E + + A EA+EN+RTV +L E + + L + ++A I G
Sbjct: 879 GNAKRDKKEMEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLHGPYRNSVRKAHIYGI 938
Query: 1026 ANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRK 847
+ + +F YA F+FG++L++ + D LV + + A G A ++ PD+ K
Sbjct: 939 TFSISQAFMYFSYAGCFRFGSYLIVNGHMRFKDVILVFSAIVLGAVALGHASSFAPDYAK 998
Query: 846 AIHAAGLIFHLFTYPAIMPYDSSQGKRNIK-NGEIELKNVSFEYAQRSDKMILDGVSLKL 670
A +A +F LF ++ S +G K G + V F Y R++ +L G+SL++
Sbjct: 999 AKLSAAYLFSLFERQPLIDSYSREGMWPDKFEGSVTFNEVVFNYPTRANVPVLQGLSLEV 1058
Query: 669 PAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEP 490
G+TLALVG SG GKST++ LLERFY + G V +D + +N+ LR + +VSQEP
Sbjct: 1059 KKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVLLDGQEAKKLNVQWLRAQLGIVSQEP 1118
Query: 489 VLFNCSIKENFLFG-ISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQ 313
+LF+CSI +N +G S SQ EI +A K AN F+ PQ +T VG++G QLSGGQ
Sbjct: 1119 ILFDCSIAKNIAYGDNSRVVSQDEIVRAAKEANIHPFIETLPQKYETRVGDKGTQLSGGQ 1178
Query: 312 KQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNA 133
KQRIAIARA++R P+VLLLDEATSALD++SEKVVQ ALD A E + +V+AHRLST+ NA
Sbjct: 1179 KQRIAIARALIRQPRVLLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNA 1238
Query: 132 DSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
D I V+ NGKV E GTH++LL ++ IY+ +V Q
Sbjct: 1239 DLIVVIDNGKVKEHGTHQQLLAQKGIYFSMVNIQ 1272
Score = 315 bits (808), Expect = 4e-84
Identities = 204/586 (34%), Positives = 317/586 (53%), Gaps = 6/586 (1%)
Frame = -1
Query: 3651 FFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFESDMNRV 3472
F +G + +I G QP S L E + + + + N
Sbjct: 710 FVVGTLCAIANGALQPAFSIILSEMIAIFGPGDDTVK----------------QQKCNMF 753
Query: 3471 VLLFFLVGF-AYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGM--STGHL 3301
L+F +G ++FTF FLQ G+ +R +LR+D+S+FD STG L
Sbjct: 754 SLVFLGLGVHSFFTF-FLQGFTFGKAGEILTTRLRSMAFKAMLRQDMSWFDDHKNSTGAL 812
Query: 3300 SIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLL 3121
S L + + + ++ALI + G I++F W+L I ++G++
Sbjct: 813 STRLATDAAQVQGATGTRLALIAQNTANLGTGIIISFIYGWQLTLLLLSVVPFIAVAGIV 872
Query: 3120 DSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNR 2941
+ N ++ + + AG IA +A+ +TV SL +++ Y E+L + ++ +
Sbjct: 873 EMKMLAGNAKRDKKEMEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLHGPYRNSVRK 932
Query: 2940 AFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEAILH 2761
A ++ ++ S F FG+ +I G + V+ + I+ G+ LG A
Sbjct: 933 AHIYGITFSISQAFMYFSYAGCFRFGSYLIVNGHMRFKDVILVFSAIVLGAVALGHASSF 992
Query: 2760 ISRLASAIPLTVPIADILLDSDATADEFFSEEI-KDTFQGIISFKNVLFSYPTRPDVPVL 2584
A A L+ L + D + E + D F+G ++F V+F+YPTR +VPVL
Sbjct: 993 APDYAKA-KLSAAYLFSLFERQPLIDSYSREGMWPDKFEGSVTFNEVVFNYPTRANVPVL 1051
Query: 2583 KEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAM 2404
+ +S V+ G+ +ALVG+SG GKSTV+QLL +Y+ +G + +DG + +N++ LR +
Sbjct: 1052 QGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVLLDGQEAKKLNVQWLRAQL 1111
Query: 2403 GVVFQEPVLFNTSIEENIRFGKPD--ATEQEIIDALKNANAFDFVCNFPDGIKTIVGERG 2230
G+V QEP+LF+ SI +NI +G ++ EI+ A K AN F+ P +T VG++G
Sbjct: 1112 GIVSQEPILFDCSIAKNIAYGDNSRVVSQDEIVRAAKEANIHPFIETLPQKYETRVGDKG 1171
Query: 2229 AQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHR 2050
QLSGGQKQRIAIAR L+R PR+LLLDEATSALD ESE +VQEAL KA GRT IV+AHR
Sbjct: 1172 TQLSGGQKQRIAIARALIRQPRVLLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHR 1231
Query: 2049 LSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTN 1912
LSTI+NA+ I+V++ G++ E G H+QL+A G+Y ++V Q + N
Sbjct: 1232 LSTIQNADLIVVIDNGKVKEHGTHQQLLAQKGIYFSMVNIQAGTQN 1277
>gi|48267183|gb|AAQ63650.3| multi-drug resistance P-glycoprotein 1;
PGY1; MDR1; GP170; ABC20; P-GP [Oryctolagus cuniculus]
Length = 1279
Score = 729 bits (1881), Expect = 0.0
Identities = 442/1232 (35%), Positives = 669/1232 (53%), Gaps = 21/1232 (1%)
Frame = -1
Query: 3663 EKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAI----NNKTIDPVDLAHAYKL 3496
+KL +G + +I+ G P G+ + N I N + + + Y+
Sbjct: 45 DKLYMVVGTLAAIIHGAALPLMMLVFGDMTDSFSNPGNMIPANITNLNMSNISASEIYEH 104
Query: 3495 FESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGM 3316
E +M + +G ++Q S + +R+Q+ ++R++I +FD
Sbjct: 105 LEEEMTTYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQTFKIRKQFFHSIMRQEIGWFDVH 164
Query: 3315 STGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIV 3136
G L+ L D++ + + +KI + ++ F G I+ F W+L S +
Sbjct: 165 DVGELNTRLTDDVSKINDGIGDKIGMFFQSMSTFFTGFIVGFTRGWKLTLVILAISPVLG 224
Query: 3135 LSGLLDSWGKMKNNEKQNEHIS--NAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNG 2962
LS L W K+ ++ E ++ AG++A + L +TV + GQQ+E+ERY + L+
Sbjct: 225 LSAAL--WAKIMSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQQKELERYNKNLEEA 282
Query: 2961 EKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYC 2782
++ + +A ++S + A + ++ ++ + G V+ + + +L G++
Sbjct: 283 KRIGIKKAITANISVGVAFLLMYASYALAFWYWNHLGHLKEYSIGQVLTVFFSVLVGAFS 342
Query: 2781 LGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPT 2605
+G+A ++ A+A I I+ D+ + D + K D +G + F+NV FSYP+
Sbjct: 343 IGQASPNVEAFANARGAAYEIFRII-DNMPSIDSYSEAGHKPDNIKGNLEFRNVHFSYPS 401
Query: 2604 RPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINI 2425
R +V +LK ++ V+ G+ +ALVG SG GKST +QL+ Y+ G +SIDG DI +N+
Sbjct: 402 RKEVKILKGLNLKVESGQTVALVGNSGCGKSTTVQLMRRLYDPTDGVVSIDGQDIRTMNV 461
Query: 2424 KQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTI 2245
+ LR+ GVV QEPVLF T+I EN+R+G+ D T EI A+K ANA++F+ P T+
Sbjct: 462 RYLREITGVVSQEPVLFATTIAENVRYGREDVTMDEIEKAVKEANAYNFIMKLPHKFDTL 521
Query: 2244 VGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTI 2065
VGERGAQLSGGQKQRIAIAR LVRNP+ILLLDEATSALD ESE +VQ AL KA GRTTI
Sbjct: 522 VGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTI 581
Query: 2064 VVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNENEE 1885
V+AHRLST+RNA+ I + G IVE G+H++L+ GVY LV Q + N E
Sbjct: 582 VIAHRLSTVRNADVIAGFDNGVIVERGNHEELMRQKGVYFRLVTMQTAGNEIDLENSASE 641
Query: 1884 ---------RVTRQSSHSDFPSNEISHQKIDQEDDYVKKL-IAEIKEEGAKKSNICEIIK 1735
++ + S S SH+ KL E + E + I+K
Sbjct: 642 SRGEKMDLVEMSAKESGSSLIRRRSSHKSFHGAQGQDGKLSTTEAQNENVPPVSFWRIMK 701
Query: 1734 YCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWALSILFLAF 1555
+E+ + V+ + I G P + + K + + D+ + + S+LFL
Sbjct: 702 LNLTEWPYFLVGVICAIINGGLQPAFAVVFSKIVGVFTRNDDDETKRRNSDLFSLLFLIL 761
Query: 1554 TRPIFI--FFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADS 1381
FI F Q + FGK E L+ +LR M FK ++ +++DDP +T L+ RL D+
Sbjct: 762 GIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTRLANDA 821
Query: 1380 SNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQA 1201
+ V A RL + + + +I+S Y W+++L +L P++ +AG +
Sbjct: 822 AQVKGATGSRLAVIAQNIANLGTGIIISLVYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQ 881
Query: 1200 VEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTAN 1021
+D E S + A EA+EN RTV +L E + + LQ + ++A I G
Sbjct: 882 ALKDKKELEGSGKIATEAIENFRTVVSLTREQKFENMYAQSLQVPYRNSLEKAHIFGITF 941
Query: 1020 GFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKA- 844
F + +F YA F+FG +LV RE + + LV + A G ++ PD+ KA
Sbjct: 942 SFTQAMMYFSYAGCFRFGAFLVARELMSFENVLLVFSAVVFGAMAVGQVSSFAPDYAKAK 1001
Query: 843 IHAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPA 664
I A+ +I L P I Y + K G + K+V F Y R D +L G++L++
Sbjct: 1002 ISASHIIMILEKLPKIDSYSTEGLKPGTLEGNMTFKDVVFNYPTRPDIPVLQGLNLQVKK 1061
Query: 663 GRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVL 484
G+TLALVGPSG GKST++ L+ERFY + G V +D + V +N+ LR + +VSQEP+L
Sbjct: 1062 GQTLALVGPSGCGKSTVVQLIERFYDPLAGTVLLDGKEVNQLNVQWLRAHLGIVSQEPIL 1121
Query: 483 FNCSIKENFLFG-ISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQ 307
F+CSI EN +G S SQ EI +A K AN +F+ P +T VG++G QLSGGQKQ
Sbjct: 1122 FDCSIAENIAYGDNSRVVSQDEIIKAAKEANIHAFIDSLPDKYNTRVGDKGTQLSGGQKQ 1181
Query: 306 RIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADS 127
RIAIARA++R P +LLLDEATSA D++SEKVVQ ALD A E + VV+AHRLST+ NAD
Sbjct: 1182 RIAIARALVRQPHILLLDEATSAPDTESEKVVQEALDKAREGRTCVVIAHRLSTIQNADM 1241
Query: 126 IAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
I V +NG+V E GTH +LL ++ IY+ +V Q
Sbjct: 1242 IVVFQNGRVKECGTHHQLLAQKGIYFSMVSVQ 1273
>gi|17569143|ref|NP_509901.1| P-GlycoProtein related (pgp-3)
[Caenorhabditis elegans]
gi|29429184|sp|P34713|MDR3_CAEEL Multidrug resistance protein 3
(P-glycoprotein C)
gi|7511155|pir||T22094 hypothetical protein ZK455.7 - Caenorhabditis
elegans
gi|3877009|emb|CAA91467.1| Hypothetical protein ZK455.7
[Caenorhabditis elegans]
gi|3881645|emb|CAA91495.1| C. elegans PGP-3 protein (corresponding
sequence ZK455.7) [Caenorhabditis elegans]
Length = 1268
Score = 728 bits (1880), Expect = 0.0
Identities = 428/1236 (34%), Positives = 698/1236 (55%), Gaps = 27/1236 (2%)
Frame = -1
Query: 3657 LLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFESDMN 3478
+LF G++ S + G PF S + L++ + N TI+ F S++
Sbjct: 44 ILFSGGLILSAVNGALVPFNSLIFEGIANALMEGESQYQNGTIN-------MPWFSSEIK 96
Query: 3477 RVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMSTGHLS 3298
L +F +G A F + S + + + + +R++Y+ +LR+D +FD + G L+
Sbjct: 97 MFCLRYFYLGVALFLCSYFANSCLYTLCERRLHCIRKKYLKSVLRQDAKWFDETTIGGLT 156
Query: 3297 IVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLLD 3118
++ +E+ ++ +K+ +++ + F+ G + FY W+L + + + L +
Sbjct: 157 QKMSSGIEKIKDGIGDKVGVLVGGVATFISGVSIGFYMCWQLTLV-MMITVPLQLGSMYL 215
Query: 3117 SWGKMKNNEKQNEH--ISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALN 2944
S K N +NE SNAG +A + + +TV + N Q E+ RY +L + +
Sbjct: 216 S-AKHLNRATKNEMSAYSNAGGMANEVIAGIRTVMAFNAQPFEINRYAHQLNEARRMGIR 274
Query: 2943 RAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEAIL 2764
+A + ++ + V ++GA + G + G V + + +L G+ LGEA
Sbjct: 275 KAIILAICTAFPLMLMFTCMAVAFWYGATLAAAGAVSSGAVFAVFWAVLIGTRRLGEAAP 334
Query: 2763 HISRLASAIPLTVPIADI--LLDSDATADEFFSE-EIKDTFQGIISFKNVLFSYPTRPDV 2593
H+ + A + I DI ++D + SE +I + QG ++F + F+YPTRP++
Sbjct: 335 HLGAITGA---RLAIHDIFKVIDHEPEIKCTSSEGKIPEKIQGKLTFDGIEFTYPTRPEL 391
Query: 2592 PVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLR 2413
+LK +SF V GE +ALVG SG GKST I LL+ +YN +G I +DG I NI+ LR
Sbjct: 392 KILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRWLR 451
Query: 2412 QAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGER 2233
+G+V QEP++F ++ ENIR G T+Q+I +A K ANA +F+C D T++G
Sbjct: 452 STIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIGAG 511
Query: 2232 GAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAH 2053
QLSGGQKQR+AIAR +VR P+ILLLDEATSALD ESE +VQ AL KAS GRTT+ +AH
Sbjct: 512 AVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCIAH 571
Query: 2052 RLSTIRNANKIIVMEKGEIVEVGDHKQLIAM-NGVYNNLVQTQLMSTNYE--KMNENEER 1882
RLSTIRNA+KI+V ++G I E G H +LI+ +G+Y ++V+ Q + E +++ E+
Sbjct: 572 RLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAKEDTTLDDEEDE 631
Query: 1881 VTRQSSHSDFPSNEIS---HQKIDQEDDYVKKLI----------------AEIKEEGAKK 1759
T +S H D +++ Q + ++ +++ + E+ EEGA +
Sbjct: 632 KTHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPEWEIENAREEMIEEGAME 691
Query: 1758 SNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWA 1579
+++ +I KY E + I+++ + I+G +P S + + ++ + D++ K+ +
Sbjct: 692 ASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIKALLNS 751
Query: 1578 LSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSN 1399
L + LAFT I GK E +S +LR F+++M +++DD H L++
Sbjct: 752 LWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVGSLTS 811
Query: 1398 RLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCND 1219
RL D+ NV AA+D RL V+ +V++ V ++F+Y W M+ L LL +
Sbjct: 812 RLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGLATALLLVVVQSSVA 871
Query: 1218 NFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAV 1039
++ + D + +++R E++ N +TV+AL + + T+ + R +
Sbjct: 872 QYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIVRGL 931
Query: 1038 IQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLP 859
Q + A S + +A+++ FG WL+ P + V+ L+M + A +Y P
Sbjct: 932 WQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAASYFP 991
Query: 858 DHRKAIHAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVS 679
++ +A +AG++F + +++ G G I ++ V F Y R +++LDG +
Sbjct: 992 EYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFAYPNRRRQLVLDGFN 1051
Query: 678 LKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVS 499
+ G+T+ALVGPSG GKST I L+ER+Y A+ G VKID+ ++ D+++ HLR++++LV
Sbjct: 1052 MSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNIALVG 1111
Query: 498 QEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSG 319
QEP LFN +I+EN +G+ N +Q ++++A +AN +FV P G DT VG G +LSG
Sbjct: 1112 QEPTLFNLTIRENITYGL-ENITQDQVEKAATLANIHTFVMGLPDGYDTSVGASGGRLSG 1170
Query: 318 GQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVV 139
GQKQR+AIARAI+R+PK+LLLDEATSALD++SEK+VQ ALD A + VV+AHRLST+
Sbjct: 1171 GQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRLSTIQ 1230
Query: 138 NADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
NAD I V +NGK E+GTH+ LL +R +Y+RLV+KQ
Sbjct: 1231 NADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 1266
>gi|7511698|pir||T31073 multidrug resistance p-glycoprotein - nematode
(Haemonchus contortus)
gi|3057042|gb|AAC38987.1| P-glycoprotein [Haemonchus contortus]
Length = 1275
Score = 728 bits (1879), Expect = 0.0
Identities = 432/1237 (34%), Positives = 687/1237 (54%), Gaps = 19/1237 (1%)
Frame = -1
Query: 3684 IKCTTRYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNA---INNKTIDPVDL 3514
+ T + +L G + + G LG + V ++ N+ + + DP L
Sbjct: 40 LSLATTLDYVLLAAGTLAPCVHGAGFSVLGIVLGGMTTVFLRAQNSEFVLGTVSRDPEGL 99
Query: 3513 -AHAYKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKD 3337
A + F++ + R L + +GFA F ++Q + + + +R+ Y+ +LR+
Sbjct: 100 PALTKEEFDTLVRRYCLYYLGLGFAMFATSYIQIVCWETFAERITHKLRKIYLKAILRQQ 159
Query: 3336 ISYFDGMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGT 3157
IS+FD TG+L+ L D++ER RE +K++L I +++ FV G + F W +
Sbjct: 160 ISWFDIQQTGNLTARLTDDLERVREGLGDKLSLFIQMVSAFVAGFCVGFAYSWSMTLVMM 219
Query: 3156 VFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTE 2977
V + IV+S S + + E + AG+IA + +TV S+ G ++E+ R+
Sbjct: 220 VVAPFIVISANWMSKIVATRTQVEQETYAVAGAIAEETFSSIRTVHSICGHKRELTRFEA 279
Query: 2976 ELKNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIY-EGTIEPGVVVRILYYI 2800
L+ G + L + F + T + ++G+ +I + ++ G + + + +
Sbjct: 280 ALEKGRQTGLVKYFYMGVGVGFGQMCTYVSYALAFWYGSVLIINDPALDRGRIFTVFFAV 339
Query: 2799 LFGSYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIKDTFQGIISFKNVL 2620
+ GS LG + H++ ++ A + ++ + + +G I FKNV
Sbjct: 340 MSGSAALGTCLPHLNTISIARGAVRSVLSVINSRPKIDPYSLDGIVLNNMRGSIRFKNVH 399
Query: 2619 FSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDI 2440
FSYP+R + +LK +S V G+ IALVG+SG GKST + LLL +Y+ G+++ID D+
Sbjct: 400 FSYPSRRTLQILKGVSLQVSAGQKIALVGSSGCGKSTNVNLLLRFYDPTRGKVTIDDIDV 459
Query: 2439 YNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPD 2260
++N+++LR+ +GVV QEPVLF+ ++ ENI+ G AT +E+ +A + ANA DF P+
Sbjct: 460 CDLNVQKLREQIGVVSQEPVLFDGTLFENIKMGYEQATMEEVQEACRVANAADFTKRLPE 519
Query: 2259 GIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASI 2080
G T VGERG QLSGGQKQRIAIAR +++NPRILLLDEATSALD E+E IVQEAL+KA
Sbjct: 520 GYGTRVGERGVQLSGGQKQRIAIARAIIKNPRILLLDEATSALDTEAESIVQEALEKAQK 579
Query: 2079 GRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKM 1900
GRTT++VAHRLSTIRN ++I V + G IVE G H +L+ GV+ + Q Q++
Sbjct: 580 GRTTVIVAHRLSTIRNVDQIFVFKNGTIVEQGTHAELMNKRGVFFEMTQAQVL------R 633
Query: 1899 NENEERVTRQSSHSDFPSNEI-------------SHQKIDQEDDYVKKLIAEIKEEGAKK 1759
E EE V + SD S +I S + V+ + E+++ AK
Sbjct: 634 QEKEEEVLDSDAESDVVSPDIALPHLSSLRSRKESTRSAISAVPSVRSMQIEMEDLRAKP 693
Query: 1758 SNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWA 1579
+ + +I + R ++ + ++ I G P + L + + Y+ D+M FW
Sbjct: 694 TPMSKIFYFNRDKWGYFILGLIACIITGTVTPTFAVLYAQIIQVYSEPVDQMKGHVLFWC 753
Query: 1578 LSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSN 1399
+ + + FF G+ E L+ KLR +FK+L+ FYDD H +L
Sbjct: 754 GAFIVIGLVHAFAFFFSAICLGRCGEALTKKLRFEAFKNLLRQNVGFYDDIRHGTGKLCT 813
Query: 1398 RLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCND 1219
R D+ NV V RL V+ ++V I+ A+++ F + W+++L +++ PL+ +GY
Sbjct: 814 RFATDAPNV-RYVFTRLPGVLSSVVTIIGALVIGFIFGWQLALILMVMVPLIIGSGYFEM 872
Query: 1218 NFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAV 1039
D+ E++ + A +A+EN+RTV ALN + + + +L++ +A
Sbjct: 873 RMQFGKKMRDTELLEEAGKVASQAVENIRTVHALNRQEQFHFMYCEYLKEPYRENLCQAH 932
Query: 1038 IQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLP 859
G F+ S FF+YAV+F G V + P+D Y V G+ +++P
Sbjct: 933 TYGGVFAFSQSLLFFMYAVAFWIGAIFVDNHSMQPIDVYRVFFAFMFCGQMVGNISSFIP 992
Query: 858 DHRKAIHAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVS 679
D KA AA L+F+L +P+ + S G +G I +NV F Y R +L G++
Sbjct: 993 DVVKARLAASLLFYLIEHPSEIDNLSEDGVTKKISGHISFRNVYFNYPTRRQIRVLRGLN 1052
Query: 678 LKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVS 499
L++ G T+ALVG SG GKST+++LLERFY+ G + +D EN+ ++N+ +LRE V +VS
Sbjct: 1053 LEINPGTTVALVGQSGCGKSTVMALLERFYNQNKGVITVDGENIRNMNIRNLREQVCIVS 1112
Query: 498 QEPVLFNCSIKENFLFGISH-NASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLS 322
QEP LF+C+I EN +G+ S ++ A K+AN +FV P+G DT VGE+G QLS
Sbjct: 1113 QEPTLFDCTIMENICYGLDDPKPSYEQVVAAAKMANIHNFVLGLPEGYDTRVGEKGTQLS 1172
Query: 321 GGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTV 142
GGQKQRIAIARA++R+P +LLLDEATSALD++SEK+VQ+AL+ A + + +V+AHRLST+
Sbjct: 1173 GGQKQRIAIARALIRDPPILLLDEATSALDTESEKIVQDALEVARQGRTCLVIAHRLSTI 1232
Query: 141 VNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
++D I +++ GK ++GTHE LL K +Y RL + Q
Sbjct: 1233 QDSDVIVMIQEGKATDRGTHEHLLMKNDLYKRLCETQ 1269
Score = 320 bits (820), Expect = 2e-85
Identities = 194/538 (36%), Positives = 293/538 (54%), Gaps = 2/538 (0%)
Frame = -1
Query: 1623 AFDKDEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPC 1444
A K+E + + L L L F + Q + AE+++ KLR + K ++
Sbjct: 101 ALTKEEFDTLVRRYCLYYLGLGFAMFATSYIQIVCWETFAERITHKLRKIYLKAILRQQI 160
Query: 1443 AFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQV 1264
+++D L+ RL D V + D+L I + A + + F YSW M+L +
Sbjct: 161 SWFD--IQQTGNLTARLTDDLERVREGLGDKLSLFIQMVSAFVAGFCVGFAYSWSMTLVM 218
Query: 1263 LMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVT 1084
++ P + ++ V + + + + A E ++RTV ++ R +
Sbjct: 219 MVVAPFIVISANWMSKIVATRTQVEQETYAVAGAIAEETFSSIRTVHSICGHKRELTRFE 278
Query: 1083 SHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTL 904
+ L+K R + + G GF C + YA++F +G+ L++ + L +
Sbjct: 279 AALEKGRQTGLVKYFYMGVGVGFGQMCTYVSYALAFWYGSVLIINDPALDRGRIFTVFFA 338
Query: 903 SMTASYA-GSAVAYLPDHRKAIHAAGLIFHLF-TYPAIMPYDSSQGKRNIKNGEIELKNV 730
M+ S A G+ + +L A A + + + P I PY N G I KNV
Sbjct: 339 VMSGSAALGTCLPHLNTISIARGAVRSVLSVINSRPKIDPYSLDGIVLNNMRGSIRFKNV 398
Query: 729 SFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEEN 550
F Y R IL GVSL++ AG+ +ALVG SG GKST ++LL RFY G+V ID+ +
Sbjct: 399 HFSYPSRRTLQILKGVSLQVSAGQKIALVGSSGCGKSTNVNLLLRFYDPTRGKVTIDDID 458
Query: 549 VVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQF 370
V D+N+ LRE + +VSQEPVLF+ ++ EN G A+ E+ +A +VANA F +
Sbjct: 459 VCDLNVQKLREQIGVVSQEPVLFDGTLFENIKMGYEQ-ATMEEVQEACRVANAADFTKRL 517
Query: 369 PQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTA 190
P+G T VGERG QLSGGQKQRIAIARAI++NP++LLLDEATSALD+++E +VQ AL+ A
Sbjct: 518 PEGYGTRVGERGVQLSGGQKQRIAIARAIIKNPRILLLDEATSALDTEAESIVQEALEKA 577
Query: 189 SERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQVE 16
+ +TV+VAHRLST+ N D I V KNG + EQGTH EL+ KR +++ + Q Q ++ E
Sbjct: 578 QKGRTTVIVAHRLSTIRNVDQIFVFKNGTIVEQGTHAELMNKRGVFFEMTQAQVLRQE 635
>gi|6679297|ref|NP_032856.1| ATP-binding cassette, sub-family B
(MDR/TAP), member 4; P glycoprotein 2 [Mus musculus]
gi|126929|sp|P21440|MDR2_MOUSE Multidrug resistance protein 2
(P-glycoprotein 2)
gi|72476|pir||DVMS2 multidrug resistance protein 2 - mouse
gi|387428|gb|AAA39516.1| multidrug resistance protein
Length = 1276
Score = 728 bits (1878), Expect = 0.0
Identities = 438/1235 (35%), Positives = 678/1235 (54%), Gaps = 24/1235 (1%)
Frame = -1
Query: 3663 EKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFESD 3484
+KL FLG + +I G P GE + V T + + + + ++ E +
Sbjct: 50 DKLFMFLGTLMAIAHGSGLPLMMIVFGEMTDKFVDNTGNFSLPVNFSLSMLNPGRILEEE 109
Query: 3483 MNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMSTGH 3304
M R + +G ++Q S +R+++ +LR+++ +FD T
Sbjct: 110 MTRYAYYYSGLGGGVLVAAYIQVSFWTLAAGRQIKKIRQKFFHAILRQEMGWFDIKGTTE 169
Query: 3303 LSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGL 3124
L+ L D++ + E +K+ + + F G I+ F W+L + + +L
Sbjct: 170 LNTRLTDDVSKISEGIGDKVGMFFQAIATFFAGFIVGFIRGWKLTL--VIMAISPILGLS 227
Query: 3123 LDSWGKMKN--NEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYA 2950
W K+ + ++K+ + AG++A +A G +TV + GQ +E+ERY + L+N +K
Sbjct: 228 TAVWAKILSTFSDKELAAYAKAGAVAEEAPGAIRTVIAFGGQNKELERYQKHLENAKKIG 287
Query: 2949 LNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEA 2770
+ +A ++S + A + ++G+ ++ G + + + IL G++ +G+A
Sbjct: 288 IKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQA 347
Query: 2769 ILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPTRPDV 2593
I A+A I DI+ D++ D F K D +G + F +V FSYP+R ++
Sbjct: 348 APCIDAFANARGAAYVIFDII-DNNPKIDSFSERGHKPDNIKGNLEFSDVHFSYPSRANI 406
Query: 2592 PVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLR 2413
+LK ++ V+ G+ +ALVG SG GKST +QLL Y+ G+ISIDG DI N N++ LR
Sbjct: 407 KILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGKISIDGQDIRNFNVRCLR 466
Query: 2412 QAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGER 2233
+ +GVV QEPVLF+T+I ENIR+G+ + T EI A+K ANA+DF+ P T+VG+R
Sbjct: 467 EIIGVVSQEPVLFSTTIAENIRYGRGNVTMDEIEKAVKEANAYDFIMKLPQKFDTLVGDR 526
Query: 2232 GAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAH 2053
GAQLSGGQKQRIAIAR LVRNP+ILLLDEATSALD ESE VQ AL KA GRTTIV+AH
Sbjct: 527 GAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAH 586
Query: 2052 RLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQ-----TQLMSTNYEKMNENE 1888
RLSTIRNA+ I E G IVE G H +L+ G+Y LV +Q++S +E +E
Sbjct: 587 RLSTIRNADVIAGFEDGVIVEQGSHSELMKKEGIYFRLVNMQTAGSQILSEEFEVELSDE 646
Query: 1887 E------------RVTRQSSHSDFPSNEISHQ-KIDQEDDYVKKLIAEIKEEGAKKSNIC 1747
+ R+ R S+ S HQ ++D+E + + + + +
Sbjct: 647 KAAGDVAPNGWKARIFRNSTKKSLKS---PHQNRLDEETNELDANVPPV--------SFL 695
Query: 1746 EIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEM-LSKSHFWALSI 1570
+++K ++E+ + + + G P S ++ + + D + K + ++L
Sbjct: 696 KVLKLNKTEWPYFVVGTVCAIANGALQPAFSIILSEMIAIFGPGDDAVKQQKCNMFSLVF 755
Query: 1569 LFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLN 1390
L L F Q + FGK E L+ +LRSM+FK ++ +++DD ++ LS RL
Sbjct: 756 LGLGVLSFFTFFLQGFTFGKAGEILTTRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLA 815
Query: 1389 ADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFV 1210
D++ V A +L + + +I+SF Y W+++L +L P + +AG +
Sbjct: 816 TDAAQVQGATGTKLALIAQNTANLGTGIIISFIYGWQLTLLLLSVVPFIAVAGIVEMKML 875
Query: 1209 DQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQG 1030
+ D E + + A EA+EN+RTV +L E + + L + ++A I G
Sbjct: 876 AGNAKRDKKEMEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLHGPYRNSVRKAHIYG 935
Query: 1029 TANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHR 850
+ + +F YA F+FG++L++ + D LV + + A G A ++ PD+
Sbjct: 936 ITFSISQAFMYFSYAGCFRFGSYLIVNGHMRFKDVILVFSAIVLGAVALGHASSFAPDYA 995
Query: 849 KAIHAAGLIFHLFTYPAIMPYDSSQGKRNIK-NGEIELKNVSFEYAQRSDKMILDGVSLK 673
KA +A +F LF ++ S +G K G + V F Y R++ +L G+SL+
Sbjct: 996 KAKLSAAYLFSLFERQPLIDSYSGEGLWPDKFEGSVTFNEVVFNYPTRANVPVLQGLSLE 1055
Query: 672 LPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQE 493
+ G+TLALVG SG GKST++ LLERFY + G V +D + +N+ LR + +VSQE
Sbjct: 1056 VKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVLLDGQEAKKLNVQWLRAQLGIVSQE 1115
Query: 492 PVLFNCSIKENFLFG-ISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGG 316
P+LF+CSI EN +G S EI +A K AN F+ PQ +T VG++G QLSGG
Sbjct: 1116 PILFDCSIAENIAYGDNSRVVPHDEIVRAAKEANIHPFIETLPQKYNTRVGDKGTQLSGG 1175
Query: 315 QKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVN 136
QKQRIAIARA++R P+VLLLDEATSALD++SEKVVQ ALD A E + +V+AHRLST+ N
Sbjct: 1176 QKQRIAIARALIRQPRVLLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQN 1235
Query: 135 ADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
AD I V++NGKV E GTH++LL ++ IY+ +V Q
Sbjct: 1236 ADLIVVIENGKVKEHGTHQQLLAQKGIYFSMVNIQ 1270
Score = 327 bits (839), Expect = 1e-87
Identities = 193/513 (37%), Positives = 297/513 (57%), Gaps = 2/513 (0%)
Frame = -1
Query: 1536 FFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVD 1357
+ Q F+ A + K+R F ++ ++D T L+ RL D S ++ +
Sbjct: 129 YIQVSFWTLAAGRQIKKIRQKFFHAILRQEMGWFD--IKGTTELNTRLTDDVSKISEGIG 186
Query: 1356 DRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAF 1177
D++G + I+ F WK++L ++ P+L L+ + +++ A+
Sbjct: 187 DKVGMFFQAIATFFAGFIVGFIRGWKLTLVIMAISPILGLSTAVWAKILSTFSDKELAAY 246
Query: 1176 EKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYF 997
K+ A EA +RTV A +N+ + HL+ + K+A+ + G A +
Sbjct: 247 AKAGAVAEEAPGAIRTVIAFGGQNKELERYQKHLENAKKIGIKKAISANISMGIAFLLIY 306
Query: 996 FIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFH 817
YA++F +G+ LV+ +E + V ++ + A G A + A AA +IF
Sbjct: 307 ASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFD 366
Query: 816 LFTYPAIMPYDSSQGKR--NIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALV 643
+ + S +G + NIK G +E +V F Y R++ IL G++LK+ +G+T+ALV
Sbjct: 367 IIDNNPKIDSFSERGHKPDNIK-GNLEFSDVHFSYPSRANIKILKGLNLKVKSGQTVALV 425
Query: 642 GPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKE 463
G SG GKST + LL+R Y +G++ ID +++ + N+ LRE + +VSQEPVLF+ +I E
Sbjct: 426 GNSGCGKSTTVQLLQRLYDPTEGKISIDGQDIRNFNVRCLREIIGVVSQEPVLFSTTIAE 485
Query: 462 NFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAI 283
N +G N + EI++A+K ANA+ F+ + PQ DTLVG+RGAQLSGGQKQRIAIARA+
Sbjct: 486 NIRYGRG-NVTMDEIEKAVKEANAYDFIMKLPQKFDTLVGDRGAQLSGGQKQRIAIARAL 544
Query: 282 LRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGK 103
+RNPK+LLLDEATSALD++SE VQ ALD A E +T+V+AHRLST+ NAD IA ++G
Sbjct: 545 VRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTIRNADVIAGFEDGV 604
Query: 102 VAEQGTHEELLRKRSIYWRLVQKQGIQVETLIE 4
+ EQG+H EL++K IY+RLV Q + L E
Sbjct: 605 IVEQGSHSELMKKEGIYFRLVNMQTAGSQILSE 637
Score = 321 bits (823), Expect = 8e-86
Identities = 209/586 (35%), Positives = 315/586 (53%), Gaps = 6/586 (1%)
Frame = -1
Query: 3651 FFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFESDMNRV 3472
F +G V +I G QP S L E + +A+ + N
Sbjct: 708 FVVGTVCAIANGALQPAFSIILSEMIAIFGPGDDAVK----------------QQKCNMF 751
Query: 3471 VLLFFLVG-FAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGM--STGHL 3301
L+F +G ++FTF FLQ G+ +R +LR+D+S+FD STG L
Sbjct: 752 SLVFLGLGVLSFFTF-FLQGFTFGKAGEILTTRLRSMAFKAMLRQDMSWFDDHKNSTGAL 810
Query: 3300 SIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLL 3121
S L + + + K+ALI + G I++F W+L I ++G++
Sbjct: 811 STRLATDAAQVQGATGTKLALIAQNTANLGTGIIISFIYGWQLTLLLLSVVPFIAVAGIV 870
Query: 3120 DSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNR 2941
+ N ++ + + AG IA +A+ +TV SL +++ Y E+L + ++ +
Sbjct: 871 EMKMLAGNAKRDKKEMEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLHGPYRNSVRK 930
Query: 2940 AFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEAILH 2761
A ++ ++ S F FG+ +I G + V+ + I+ G+ LG A
Sbjct: 931 AHIYGITFSISQAFMYFSYAGCFRFGSYLIVNGHMRFKDVILVFSAIVLGAVALGHASSF 990
Query: 2760 ISRLASAIPLTVPIADILLDSDATADEFFSEEI-KDTFQGIISFKNVLFSYPTRPDVPVL 2584
A A L+ L + D + E + D F+G ++F V+F+YPTR +VPVL
Sbjct: 991 APDYAKA-KLSAAYLFSLFERQPLIDSYSGEGLWPDKFEGSVTFNEVVFNYPTRANVPVL 1049
Query: 2583 KEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAM 2404
+ +S V+ G+ +ALVG+SG GKSTV+QLL +Y+ +G + +DG + +N++ LR +
Sbjct: 1050 QGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVLLDGQEAKKLNVQWLRAQL 1109
Query: 2403 GVVFQEPVLFNTSIEENIRFGKPDAT--EQEIIDALKNANAFDFVCNFPDGIKTIVGERG 2230
G+V QEP+LF+ SI ENI +G EI+ A K AN F+ P T VG++G
Sbjct: 1110 GIVSQEPILFDCSIAENIAYGDNSRVVPHDEIVRAAKEANIHPFIETLPQKYNTRVGDKG 1169
Query: 2229 AQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHR 2050
QLSGGQKQRIAIAR L+R PR+LLLDEATSALD ESE +VQEAL KA GRT IV+AHR
Sbjct: 1170 TQLSGGQKQRIAIARALIRQPRVLLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHR 1229
Query: 2049 LSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTN 1912
LSTI+NA+ I+V+E G++ E G H+QL+A G+Y ++V Q + N
Sbjct: 1230 LSTIQNADLIVVIENGKVKEHGTHQQLLAQKGIYFSMVNIQAGTQN 1275
>gi|39594784|emb|CAE70652.1| Hypothetical protein CBG17357
[Caenorhabditis briggsae]
Length = 1268
Score = 720 bits (1859), Expect = 0.0
Identities = 423/1231 (34%), Positives = 691/1231 (55%), Gaps = 27/1231 (2%)
Frame = -1
Query: 3642 GVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFESDMNRVVLL 3463
G++ S + G PF S + L++ N T++ F S++ L
Sbjct: 49 GIILSAVNGALVPFNSLIFEGIANALMEGEAQYQNGTLN-------MPWFSSEIKFFCLR 101
Query: 3462 FFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMSTGHLSIVLND 3283
+F +G A F + + + + + + +R+ Y+ +LR+D +FD + G L+ ++
Sbjct: 102 YFYLGLALFLCSYCANACLYTLCERRLHCIRKHYLKSVLRQDAKWFDQHTIGGLTQKMSS 161
Query: 3282 NMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLLDSWGKM 3103
+E+ ++ +KI +I+ + F+ G L FY W+L + + + L + S K
Sbjct: 162 GIEKIKDGIGDKIGVIVGGVATFISGVSLGFYMCWQLTLV-MLITVPLQLGSMYLS-AKH 219
Query: 3102 KNNEKQNEH--ISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNRAFVF 2929
N +NE SNAG +A + + +TV + N Q E+ RY+++L+ K + +A +
Sbjct: 220 LNRATKNEMSAYSNAGGMANEVIAGIRTVMAFNAQPFEINRYSQQLEEARKMGVRKAMIL 279
Query: 2928 SLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEAILHISRL 2749
++ S V ++GA + G + G V + + +L G+ +GEA H+ +
Sbjct: 280 AICTSFPLMLMFTCMAVAFWYGATLAAAGAVSSGAVFAVFWAVLIGTRRIGEAAPHLGAI 339
Query: 2748 ASAIPLTVPIADI--LLDSDATADEFFSE-EIKDTFQGIISFKNVLFSYPTRPDVPVLKE 2578
A + I DI ++D + S+ +I D QG +SF + F+YPTRPD+ +LK
Sbjct: 340 TGA---RLAIHDIFKVIDHEPEIKCTSSDGKIPDKIQGKLSFDGIEFTYPTRPDLKILKG 396
Query: 2577 ISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAMGV 2398
+SF V GE +ALVG SG GKST I LL+ +YN +G I +DG I+ NI+ LR +G+
Sbjct: 397 VSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQGAGMIKLDGVPIHEYNIRWLRSTIGI 456
Query: 2397 VFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGERGAQLS 2218
V QEP++F ++ ENIR G T+ +I +A + ANA +F+C D T++G QLS
Sbjct: 457 VQQEPIIFVATVAENIRMGDDLITDDDIEEACRMANAHEFICKLSDKYNTVIGAGAVQLS 516
Query: 2217 GGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHRLSTI 2038
GGQKQR+AIAR +VR P+ILLLDEATSALD ESE +VQ AL KAS GRTT+ +AHRLSTI
Sbjct: 517 GGQKQRVAIARAIVRRPQILLLDEATSALDTESERMVQAALDKASKGRTTLCIAHRLSTI 576
Query: 2037 RNANKIIVMEKGEIVEVGDHKQLIAM-NGVYNNLVQTQLM------STNYEKMNENEERV 1879
+NA+KI+V ++G I E G H +LI+ +G+Y ++V Q + +T ++ +E + R+
Sbjct: 577 KNASKILVFDQGLIAERGTHDELISKEDGIYASMVAAQEIERAKEDTTLDDEEDEKDHRM 636
Query: 1878 TRQSSHSDFPSNEISHQKIDQEDDYVKKLIA---------------EIKEEGAKKSNICE 1744
+ S + E+ + +I+ E+ EEGA ++++ +
Sbjct: 637 FHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPEWEIESAREEMIEEGAMEASLVD 696
Query: 1743 IIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWALSILF 1564
I K+ E + IA++ + I+G+ +P S + + + + D++ K+ +L L
Sbjct: 697 IFKFASPEGRNIIIALVFTLIRGLTWPAFSIVYGQLFRILSAGGDDVSIKALLNSLWFLL 756
Query: 1563 LAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNAD 1384
LAFT I GK E +S +LR F+++M +++DDP H L++RL D
Sbjct: 757 LAFTSGISTLVSGGLLGKAGETMSGRLRMDVFRNIMQQDASYFDDPKHNVGALTSRLATD 816
Query: 1383 SSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQ 1204
+ NV AA+D RL V+ +V++ V ++FFY W M+ L LL + ++
Sbjct: 817 APNVQAAIDQRLAEVLTGVVSLFCGVSVAFFYGWNMAPIGLATALLLVVVQSAVAQYLKF 876
Query: 1203 AVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTA 1024
+ D + +++R E++ N +TV++L + + + + R + Q +
Sbjct: 877 RGQRDMDSAIEASRLVTESISNWKTVQSLTKQEYMYDSFVAASKSPHRRAIVRGLWQSLS 936
Query: 1023 NGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKA 844
A S + +A+++ FG WL+ P + V+ L+M + A +Y P++ +A
Sbjct: 937 FALAGSFVMWNFAIAYMFGLWLISNGWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRA 996
Query: 843 IHAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPA 664
+AG++F + +++ G G+I ++ V F Y R +++LD ++
Sbjct: 997 RISAGIMFTMIRQRSVIDNRGLTGDTPPIKGDISMREVYFAYPNRRRQLVLDSFNMTAKF 1056
Query: 663 GRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVL 484
G+T+ALVGPSG GKST I L+ER+Y A+ G++K+D ++ ++++ HLR++++LV QEP L
Sbjct: 1057 GQTVALVGPSGCGKSTTIQLIERYYDALSGKIKVDGCDIREISVKHLRDNIALVGQEPTL 1116
Query: 483 FNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQR 304
FN +I+EN +G+ SQ E+++A +AN +FV P+G DT VG G +LSGGQKQR
Sbjct: 1117 FNLTIRENITYGL-EKISQEEVEKAATLANIHTFVMGLPEGYDTSVGASGGRLSGGQKQR 1175
Query: 303 IAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSI 124
+AIARAI+R+PK+LLLDEATSALD++SEK+VQ ALD A + +V+AHRLST+ NAD I
Sbjct: 1176 VAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCIVIAHRLSTIQNADKI 1235
Query: 123 AVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
V +NGK E+GTH+ LL +R +Y+RLV+KQ
Sbjct: 1236 IVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 1266
>gi|27656758|gb|AAO20902.1| Mdr2 [Takifugu rubripes]
Length = 1271
Score = 718 bits (1853), Expect = 0.0
Identities = 453/1304 (34%), Positives = 684/1304 (51%), Gaps = 104/1304 (7%)
Frame = -1
Query: 3630 SILTGMCQPFESYTLGE-TSQVLVKVTNAINNKTIDPVDLAHAYKLFESDMNRVVLLFFL 3454
+I+ G+ P GE T + + + N+ T +P A E+DM R + + +
Sbjct: 2 AIVNGLVNPLMCIVFGEMTDSFIQEAKLSQNHNTSNP----RANSTLEADMQRFSIYYSI 57
Query: 3453 VGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMSTGHLSIVLND--- 3283
+GFA +LQ S+ A +R + ++++DIS++D TG L+ L +
Sbjct: 58 LGFAVLVVAYLQMSLWTLTAARQAKRIRELFFHGIMQQDISWYDVTETGELNTRLTEWVT 117
Query: 3282 --------------------------NMERFREVFNEKIALIIALLTDFVIGTILAFYTD 3181
++ + +E +K L+I + F+ ++ F
Sbjct: 118 HIIHTPVPVTAGVVVIICGVRFPGAHDVYKIQEGIGDKAGLLIQAASTFITSFVIGFVHG 177
Query: 3180 WRLACYGTVFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQ 3001
W+L S + LS L S K+ + AG++A + L +TV + +GQ+
Sbjct: 178 WKLTLVILAISPVLGLSAALYSKLLTSFTSKEQTAYAKAGAVAAEVLSSIRTVFAFSGQR 237
Query: 3000 QEVERYTEELKNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEG------- 2842
+ ++RY + L++ + + + + + + ++G ++
Sbjct: 238 KAIKRYHKNLEDARDMGIKKGVAANTATGFSFLMIYLSYALAFWYGTTLVLNKEYTIGNL 297
Query: 2841 ---------TIEPGVVVRILYYILFGSYCLGEAILHISRLASAIPLTVPIADILLDSDAT 2689
T+ V +++ + +L+G+Y +G+A ++ ASA + +I+ D
Sbjct: 298 LTNKSVAAETVTTCVQMKVFFVVLYGAYIIGQASPNVQSFASARGAAYKVYNII-DHKPN 356
Query: 2688 ADEFFSEEIKDTF-QGIISFKNVLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKS 2512
D F + K + +G I F+N+ FSYP+RP++ +L ++SF+V+ G+ IALVG+SG GKS
Sbjct: 357 IDSFSEDGYKPEYIKGDIVFQNIHFSYPSRPEIKILNDMSFHVRNGQTIALVGSSGCGKS 416
Query: 2511 TVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPD 2332
T IQLL +Y+ G I IDG+DI ++NI+ LR+ +GVV QEPVLF T+I ENIR+G+ D
Sbjct: 417 TTIQLLQRFYDPQKGSIFIDGHDIRSLNIRYLREMIGVVSQEPVLFATTITENIRYGRLD 476
Query: 2331 ATEQEIIDALKNANAFDFVCNFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLL 2152
T++EI A K +NA+DF+ N PD +T+VG+RG QLSGGQKQRIAIAR LVRNP+ILLL
Sbjct: 477 VTQEEIERATKESNAYDFIMNLPDKFETLVGDRGTQLSGGQKQRIAIARALVRNPKILLL 536
Query: 2151 DEATSALDNESEFIVQEALQKASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQ 1972
DEATSALD ESE IVQ AL K +GRTTIV+AHRLSTIRNA+ I GEIVE G H Q
Sbjct: 537 DEATSALDAESETIVQAALDKVRLGRTTIVIAHRLSTIRNADIIAGFSNGEIVEQGTHSQ 596
Query: 1971 LIAMNGVYNNLVQTQ-------LMSTNYE--------------KMNENEERVTRQSSHSD 1855
L+ + GVY+ LV Q L ++YE + + R TR S +
Sbjct: 597 LMEIKGVYHGLVTMQSFQKLEDLEDSDYEPWVAEKSQLIESFSQSSLQRRRSTRGSLLAV 656
Query: 1854 FPSNEISHQKIDQEDDYVKKLIAEIKEEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQG 1675
+ +K + + D ++ ++E + ++++Y SE+ + + + + I G
Sbjct: 657 SEGTKEEKEKFECDQDNIE------EDENVPPVSFFKVMRYNVSEWPYILVGTICAMING 710
Query: 1674 IYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKL 1495
P+ SI+F +F FQ + F K+ E L
Sbjct: 711 AMQPV---------------------------FSIIFTEII--MFWGFQGFCFSKSGEIL 741
Query: 1494 SIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAIL 1315
++ LR +F +M ++YD+P +T L+ RL AD+++V A RL + +
Sbjct: 742 TLNLRLKAFISMMRQDLSWYDNPKNTVGALTTRLAADAAHVQGAAGVRLAVMTQNFANLG 801
Query: 1314 LAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENV 1135
++I+SF Y W+++L +L P+L +AG + ED E + + A EA+ENV
Sbjct: 802 TSIIISFVYGWELTLLILAVVPILAVAGAAEVKLLTGHAAEDKKELEMAGKIATEAIENV 861
Query: 1134 RTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLV 955
RTV +L E + L +L + K+A I G F+ + FF+YA F+FG WL+
Sbjct: 862 RTVVSLTREPTFVALYEENLTVPYKNSQKKAKIYGLTYSFSQAMIFFVYAACFRFGAWLI 921
Query: 954 LREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKA-IHAAGLIFHLFTYPAIMPYDSS 778
+ +LV+MT+ A G A Y P+ KA I A+ L + PAI
Sbjct: 922 EAGRMDVEGVFLVVMTMLYGAMAVGEANTYAPNFAKAKISASHLTMLINRQPAIDNLSEE 981
Query: 777 QGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLE 598
+ + +G + ++V F Y R D +L G++L++ G TLALVG SG GKST I LLE
Sbjct: 982 EARLEKYDGNVLFEDVKFNYPSRPDVPVLQGLNLEVQKGETLALVGSSGCGKSTTIQLLE 1041
Query: 597 RFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFG-ISHNASQLE 421
RFY +G V +D +V +N+H LR + +VSQEPVLF+CS+ EN +G S + S E
Sbjct: 1042 RFYDPREGRVLLDGVDVKQLNVHWLRSQIGIVSQEPVLFDCSLAENIAYGDNSRSVSMDE 1101
Query: 420 IDQALKVANAFSFVSQFP----------------------------------QGLDTLVG 343
I A K AN SF+ P Q DT G
Sbjct: 1102 IVAAAKAANIHSFIEGLPQVAAVNQGKWLIPHLIDSHGAAHDHLHHIQTVSEQRYDTQAG 1161
Query: 342 ERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVV 163
++G QLSGGQKQR+AIARAI+RNPK+LLLDEATSALD++SEKVVQ ALD A + + +VV
Sbjct: 1162 DKGTQLSGGQKQRVAIARAIIRNPKLLLLDEATSALDTESEKVVQEALDQARKGRTCIVV 1221
Query: 162 AHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
AHRLST+ NAD IAV + G V E+GTH++L+ K+ +Y LV KQ
Sbjct: 1222 AHRLSTIQNADCIAVFQGGVVVEKGTHQQLIAKKGVYHMLVTKQ 1265
Score = 300 bits (767), Expect = 2e-79
Identities = 175/472 (37%), Positives = 263/472 (55%), Gaps = 17/472 (3%)
Frame = -1
Query: 1386 DSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVD 1207
D + + D+ G +I + + ++ F + WK++L +L P+L L+ +
Sbjct: 144 DVYKIQEGIGDKAGLLIQAASTFITSFVIGFVHGWKLTLVILAISPVLGLSAALYSKLLT 203
Query: 1206 QAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGT 1027
++ A+ K+ A E L ++RTV A + + + I +L+ R+ K+ V T
Sbjct: 204 SFTSKEQTAYAKAGAVAAEVLSSIRTVFAFSGQRKAIKRYHKNLEDARDMGIKKGVAANT 263
Query: 1026 ANGFACSCYFFIYAVSFKFGTWLVLREEILPMD------------TYLVLMTLSMTASYA 883
A GF+ + YA++F +GT LVL +E + T V M + Y
Sbjct: 264 ATGFSFLMIYLSYALAFWYGTTLVLNKEYTIGNLLTNKSVAAETVTTCVQMKVFFVVLYG 323
Query: 882 ----GSAVAYLPDHRKAIHAAGLIFHLFTY-PAIMPYDSSQGKRNIKNGEIELKNVSFEY 718
G A + A AA ++++ + P I + K G+I +N+ F Y
Sbjct: 324 AYIIGQASPNVQSFASARGAAYKVYNIIDHKPNIDSFSEDGYKPEYIKGDIVFQNIHFSY 383
Query: 717 AQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDV 538
R + IL+ +S + G+T+ALVG SG GKST I LL+RFY G + ID ++ +
Sbjct: 384 PSRPEIKILNDMSFHVRNGQTIALVGSSGCGKSTTIQLLQRFYDPQKGSIFIDGHDIRSL 443
Query: 537 NLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGL 358
N+ +LRE + +VSQEPVLF +I EN +G + +Q EI++A K +NA+ F+ P
Sbjct: 444 NIRYLREMIGVVSQEPVLFATTITENIRYG-RLDVTQEEIERATKESNAYDFIMNLPDKF 502
Query: 357 DTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERL 178
+TLVG+RG QLSGGQKQRIAIARA++RNPK+LLLDEATSALD++SE +VQ ALD
Sbjct: 503 ETLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAESETIVQAALDKVRLGR 562
Query: 177 STVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQ 22
+T+V+AHRLST+ NAD IA NG++ EQGTH +L+ + +Y LV Q Q
Sbjct: 563 TTIVIAHRLSTIRNADIIAGFSNGEIVEQGTHSQLMEIKGVYHGLVTMQSFQ 614
Score = 284 bits (727), Expect = 1e-74
Identities = 197/600 (32%), Positives = 307/600 (50%), Gaps = 43/600 (7%)
Frame = -1
Query: 3594 YTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFESDMNRVVLLFFLVGFAYFTFGFLQF 3415
Y + E +LV A+ N + PV F +++ + GF + G +
Sbjct: 691 YNVSEWPYILVGTICAMINGAMQPV--------FSIIFTEIIMFWGFQGFCFSKSGEI-- 740
Query: 3414 SIMKFVGDNTAYNVRRQYISRLLRKDISYFDGM--STGHLSIVLNDNMERFREVFNEKIA 3241
N+R + ++R+D+S++D + G L+ L + + ++A
Sbjct: 741 ---------LTLNLRLKAFISMMRQDLSWYDNPKNTVGALTTRLAADAAHVQGAAGVRLA 791
Query: 3240 LIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLLDSWGKMKNNEKQNEHISNAG 3061
++ + I++F W L + ++G + + + + + AG
Sbjct: 792 VMTQNFANLGTSIIISFVYGWELTLLILAVVPILAVAGAAEVKLLTGHAAEDKKELEMAG 851
Query: 3060 SIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNRAFVFSLSRSADYFFTNALNF 2881
IA +A+ +TV SL + V Y E L K + +A ++ L+ Y F+ A+ F
Sbjct: 852 KIATEAIENVRTVVSLTREPTFVALYEENLTVPYKNSQKKAKIYGLT----YSFSQAMIF 907
Query: 2880 VI----LYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEAILHISRLASAIPLTVPIAD 2713
+ FGA +I G ++ V ++ +L+G+ +GEA + A A ++
Sbjct: 908 FVYAACFRFGAWLIEAGRMDVEGVFLVVMTMLYGAMAVGEANTYAPNFAKA-KISASHLT 966
Query: 2712 ILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPTRPDVPVLKEISFNVQGGECIALV 2536
+L++ D EE + + + G + F++V F+YP+RPDVPVL+ ++ VQ GE +ALV
Sbjct: 967 MLINRQPAIDNLSEEEARLEKYDGNVLFEDVKFNYPSRPDVPVLQGLNLEVQKGETLALV 1026
Query: 2535 GASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAMGVVFQEPVLFNTSIEE 2356
G+SG GKST IQLL +Y+ GR+ +DG D+ +N+ LR +G+V QEPVLF+ S+ E
Sbjct: 1027 GSSGCGKSTTIQLLERFYDPREGRVLLDGVDVKQLNVHWLRSQIGIVSQEPVLFDCSLAE 1086
Query: 2355 NIRFG--KPDATEQEIIDALKNANAFDFVCNFPD-------------------------- 2260
NI +G + EI+ A K AN F+ P
Sbjct: 1087 NIAYGDNSRSVSMDEIVAAAKAANIHSFIEGLPQVAAVNQGKWLIPHLIDSHGAAHDHLH 1146
Query: 2259 GIKTI--------VGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQ 2104
I+T+ G++G QLSGGQKQR+AIAR ++RNP++LLLDEATSALD ESE +VQ
Sbjct: 1147 HIQTVSEQRYDTQAGDKGTQLSGGQKQRVAIARAIIRNPKLLLLDEATSALDTESEKVVQ 1206
Query: 2103 EALQKASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQL 1924
EAL +A GRT IVVAHRLSTI+NA+ I V + G +VE G H+QLIA GVY+ LV Q+
Sbjct: 1207 EALDQARKGRTCIVVAHRLSTIQNADCIAVFQGGVVVEKGTHQQLIAKKGVYHMLVTKQM 1266
>gi|39595964|emb|CAE67467.1| Hypothetical protein CBG12969
[Caenorhabditis briggsae]
Length = 1231
Score = 711 bits (1836), Expect = 0.0
Identities = 439/1219 (36%), Positives = 682/1219 (55%), Gaps = 16/1219 (1%)
Frame = -1
Query: 3723 STNNFLKKTFGFQIKCTTRYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAI 3544
S+N+F ++ ++ + + ++LL LG+ SI G C + + + VL+ +
Sbjct: 26 SSNSF---SYCSLLRYSNKVDRLLLGLGIFLSISQGCCSSLNAILFRDLTDVLISGQGSY 82
Query: 3543 NNKTIDPVDLAHAYKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQ 3364
N+T D ++ F ++ ++ +FL G F+ F+ + + +R
Sbjct: 83 TNQTFD-------HQQFNNETLNIIHTYFLYGTLLFSLSFVSMCCWHTFCERQIFKIRVA 135
Query: 3363 YISRLLRKDISYFDGMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYT 3184
Y S LLR+D +FD +G + +ND +ER R+ +K+ +IIA LT F G LAFY
Sbjct: 136 YFSALLRQDWEWFDQNDSGAAIVRMNDGLERVRDGLGDKLGVIIAYLTHFFCGLSLAFYL 195
Query: 3183 DWRLACYGTVFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQ 3004
+ + + +L ++ K K+ E +A + A + + KTV S NG+
Sbjct: 196 SVEMTIVTLIITPAFILPIIISRKMISKVTFKELEAYESAATAAGEVISGIKTVVSFNGE 255
Query: 3003 QQEVERYTEELKNGEKYALNRAFVFS----LSRSADYFFTNALNFVILYFGANMIYEGTI 2836
Q+E+ RY++ L + L RA + S L S+ F F ++G ++ +G+I
Sbjct: 256 QKEINRYSKFLSKAMYWGLWRASLSSFEGLLGHSSCVF---QWQFHSGWWGTRLVLKGSI 312
Query: 2835 EPGVVVRILYYILFGSYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK- 2659
PG + + + + Y +G+AI H++ ++S VP+ I+ D D + +K
Sbjct: 313 TPGTTLAVFWAVNGAIYFVGQAIPHLTSVSSCYSAAVPVFQII-DRTVILDGTSDKGLKL 371
Query: 2658 DTFQGIISFKNVLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYN 2479
+G + F+NV F YP R V VLK IS + GE IALVG SGSGKST L++H+Y
Sbjct: 372 SKVKGKVKFENVWFKYPARQKVNVLKGISLHANPGENIALVGHSGSGKSTTAALMMHFYE 431
Query: 2478 IDSGRISIDGNDIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALK 2299
++ G+ISID +I +N+ LR +G+V QEP+LF ++E N+R G PD + E+ K
Sbjct: 432 LNGGKISIDDTNIDELNLSHLRNIVGIVSQEPLLFADTVENNMRLGAPDLDDNEMEYYCK 491
Query: 2298 NANAFDFVCNFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNES 2119
ANA DF+ P+G KT +G G +LSGGQ+QRIAIARTL R P IL+LDEATSALD+ES
Sbjct: 492 LANAHDFIEQLPNGYKTAIGNGGVELSGGQRQRIAIARTLARKPSILILDEATSALDSES 551
Query: 2118 EFIVQEALQKASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNL 1939
E +VQ AL+ A+ GRTTI +AHRL TIRN N+I V + G+IVEVG H++L+ +G Y +
Sbjct: 552 ESLVQIALENAAEGRTTITIAHRLGTIRNCNRIYVFDDGKIVEVGSHQELMEKDGHYAKM 611
Query: 1938 VQTQLMSTNYEKMNENEE---RVTRQSSHSDFPSNEISHQKIDQEDDYVKKLIAEIK--- 1777
VQ+Q + + + EE R+S S + S + +KL+++I
Sbjct: 612 VQSQEIEVGNRQESTMEEYSFESRRESCDSKSSRQKFSKKTARSCSLTSEKLLSDISPLP 671
Query: 1776 --EEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKD-E 1606
EE + S EI++Y + E+ +L I++L S ++G YP+ S L + + + D E
Sbjct: 672 IGEENEQPSTFLEILRYTKPEWGLLAISILISVLRGFNYPIYSILYGRMFRILSTGTDEE 731
Query: 1605 MLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDP 1426
S S A+ + L I G E+L+ +LR + F +++ ++D P
Sbjct: 732 KSSNSGMNAIYLTALGIYALIVTMAAGCLIGYVGERLTKRLRILLFTNILRQDGEYFDVP 791
Query: 1425 CHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLM-FCP 1249
H RL RL+ D+ N+ AA+D RL VI A+ + ++F++S M+L L+
Sbjct: 792 EHAPGRLITRLSTDAPNIRAAIDQRLADVIQGFSAVFCGIAIAFWFSPTMALMGLVNVGV 851
Query: 1248 LLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQK 1069
L+ L G+ + + + E+DS E+ +R AIEA+E RTV+ L E + +
Sbjct: 852 LISLQGFIT-HVLKKRGEKDSERSEEPSRLAIEAVEQHRTVQYLTREQSFVKKFADGMHP 910
Query: 1068 IRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTAS 889
I +R ++Q + + S F +A+ ++FG LV + P + V+ +L+ ++
Sbjct: 911 IHIRNLQRGILQSISYALSTSYTSFSFAIGYRFGLLLVDHDLANPFTVFQVIESLNSSSP 970
Query: 888 YAGSAVAYLPDHRKAIHAAGLIFHLFTY-PAIMPYDSSQGKRNIKNGEIELKNVSFEYAQ 712
+ +Y+P+ +A +AGL+F + Y P I DS+ GK+ + +I LKNV F Y
Sbjct: 971 SLLALGSYIPEFVRAQISAGLLFQMLRYEPKI---DSNTGKKTTLDSDISLKNVYFGYQV 1027
Query: 711 RSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNL 532
KMIL +LK+ +G+T A+VG SG GKST I LLERFY + G + N+ D+NL
Sbjct: 1028 SGRKMILKDFTLKIESGKTTAIVGASGCGKSTTIQLLERFYDPIAGRIDFGSTNLRDLNL 1087
Query: 531 HHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDT 352
HLR V+LV QEP LFN SI++N +G+ + + E+ QA K+A+A F++ P+G DT
Sbjct: 1088 KHLRSQVALVEQEPTLFNYSIRKNIAYGL-ESIKEGEVIQAAKIAHAHEFITSLPEGYDT 1146
Query: 351 LVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLST 172
+VGE G++LSGGQKQRIAIARAI+RNPK+LLLDEA SALD +SE++VQ AL+ A E +
Sbjct: 1147 IVGEGGSKLSGGQKQRIAIARAIVRNPKILLLDEAMSALDVESERLVQEALEKAKEGRTC 1206
Query: 171 VVVAHRLSTVVNADSIAVL 115
VV+AHRL+T+ A I ++
Sbjct: 1207 VVIAHRLTTIRGALLILIV 1225
Score = 272 bits (696), Expect = 4e-71
Identities = 170/497 (34%), Positives = 264/497 (52%), Gaps = 2/497 (0%)
Frame = -1
Query: 1503 EKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLV 1324
E+ K+R F L+ ++D A + R+N V + D+LG +I L
Sbjct: 126 ERQIFKIRVAYFSALLRQDWEWFDQNDSGAAIV--RMNDGLERVRDGLGDKLGVIIAYLT 183
Query: 1323 AILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEAL 1144
+ ++F+ S +M++ L+ P L + + + ++ A+E + AA E +
Sbjct: 184 HFFCGLSLAFYLSVEMTIVTLIITPAFILPIIISRKMISKVTFKELEAYESAATAAGEVI 243
Query: 1143 ENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFA-CSCYFFIYAVSFKFG 967
++TV + N E + I + L K RA + SC F S +G
Sbjct: 244 SGIKTVVSFNGEQKEINRYSKFLSKAMYWGLWRASLSSFEGLLGHSSCVFQWQFHSGWWG 303
Query: 966 TWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFHLFTYPAIMPY 787
T LVL+ I P T V ++ + G A+ +L AA +F + I+
Sbjct: 304 TRLVLKGSITPGTTLAVFWAVNGAIYFVGQAIPHLTSVSSCYSAAVPVFQIIDRTVILDG 363
Query: 786 DSSQGKRNIK-NGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTII 610
S +G + K G+++ +NV F+Y R +L G+SL G +ALVG SGSGKST
Sbjct: 364 TSDKGLKLSKVKGKVKFENVWFKYPARQKVNVLKGISLHANPGENIALVGHSGSGKSTTA 423
Query: 609 SLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNAS 430
+L+ FY G++ ID+ N+ ++NL HLR V +VSQEP+LF +++ N G + +
Sbjct: 424 ALMMHFYELNGGKISIDDTNIDELNLSHLRNIVGIVSQEPLLFADTVENNMRLG-APDLD 482
Query: 429 QLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDE 250
E++ K+ANA F+ Q P G T +G G +LSGGQ+QRIAIAR + R P +L+LDE
Sbjct: 483 DNEMEYYCKLANAHDFIEQLPNGYKTAIGNGGVELSGGQRQRIAIARTLARKPSILILDE 542
Query: 249 ATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELL 70
ATSALDS+SE +VQ AL+ A+E +T+ +AHRL T+ N + I V +GK+ E G+H+EL+
Sbjct: 543 ATSALDSESESLVQIALENAAEGRTTITIAHRLGTIRNCNRIYVFDDGKIVEVGSHQELM 602
Query: 69 RKRSIYWRLVQKQGIQV 19
K Y ++VQ Q I+V
Sbjct: 603 EKDGHYAKMVQSQEIEV 619
>gi|47225423|emb|CAG11906.1| unnamed protein product [Tetraodon
nigroviridis]
Length = 1384
Score = 707 bits (1824), Expect = 0.0
Identities = 460/1377 (33%), Positives = 704/1377 (50%), Gaps = 164/1377 (11%)
Frame = -1
Query: 3669 RYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFE 3490
R++ +L G V +++ G P GE + + +N + DL L E
Sbjct: 13 RWDLVLLVSGTVMAMVNGTVMPLMCIVFGEMTDSFISSETGKHNFS----DLTLNSTLQE 68
Query: 3489 SDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMST 3310
DM R + + ++GF ++Q S +R + +++++IS+FD T
Sbjct: 69 -DMQRFAIYYSILGFVVLLAAYMQVSFWTLTAGRQVKRIRSLFFHCIMQQEISWFDVNDT 127
Query: 3309 GHLSIVLND-----------------NMERFREVFNEKIALIIALLTDFVIGTILAFYTD 3181
G L+ L + ++ + +E +K+ L+I T F+ I+ F T
Sbjct: 128 GELNTRLTEWVTQIPGGQRSNSGWLSDVYKIQEGIGDKVGLLIQAYTTFITAFIIGFTTG 187
Query: 3180 WRLACYGTVFSFGIVLSG-------------LLDSWGKMKNNE----------KQNEHIS 3070
W+L S + +S LL S N+ K+ +
Sbjct: 188 WKLTLVILAISPALAISAAFFSKVRGSCSDLLLSSSTTPPNSSSGQVLASFTNKEQTAYA 247
Query: 3069 NAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNRAFVFSLSRSADYFFTNA 2890
AG++A + L +TV + +GQ +E+ERY + L++ + + +A +++ +
Sbjct: 248 KAGAVAEEVLSAIRTVFAFSGQTKEIERYHKNLRDAKDVGIKKAISSNIAMGFTFLMIYL 307
Query: 2889 LNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEAILHISRLASAIPLTVPIADI 2710
+ ++G+ +I G ++ + + +L G++ +G+ +I ASA + I
Sbjct: 308 SYALAFWYGSTLILNQEYTIGNLLTVFFVVLIGAFSVGQTSPNIQTFASARGAAHKVYAI 367
Query: 2709 LLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPTRPDVPVLKEISFNVQGGECIALVG 2533
+ D D F + K D +G I FKN+ F YP+RP+V +L +S +V+ G+ +ALVG
Sbjct: 368 I-DHKPNIDSFSEDGFKPDYIKGDIEFKNIHFRYPSRPEVKILNNMSLSVKSGQTMALVG 426
Query: 2532 ASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAMGVVFQEPVLFNTSIEEN 2353
+SG GKST +QLL +Y+ + G I +DG+DI ++NI+ LR+ +GVV QEP+LF T+I EN
Sbjct: 427 SSGCGKSTTVQLLQRFYDPEEGAIFVDGHDIRSLNIRYLREMIGVVSQEPILFATTIAEN 486
Query: 2352 IRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGERGAQLSGGQKQRIAIARTLVR 2173
IR+G+ D T++EI A K +NA+DF+ + PD +T+VG+RG QLSGGQKQRIAIAR LVR
Sbjct: 487 IRYGRLDVTQEEIERATKESNAYDFIMSLPDKFETLVGDRGTQLSGGQKQRIAIARALVR 546
Query: 2172 NPRILLLDEATSALDNESEFIVQEALQKAS------------------------------ 2083
NP+ILLLDEATSALD ESE IVQ AL K +
Sbjct: 547 NPKILLLDEATSALDAESETIVQAALDKVATQTRAPLVRELVSLDLQLVNSRSPTREQPG 606
Query: 2082 -------IGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQL 1924
+GRTTIVVAHRLSTIRNAN I +G IVE+G H QL+ M GVY+ LV Q+
Sbjct: 607 TQLLVVRLGRTTIVVAHRLSTIRNANIIAGFSQGAIVEMGTHSQLMDMKGVYHGLVTMQV 666
Query: 1923 MSTNYEKMNENEERVTRQSSHSDFPSNEISHQK-------------------------ID 1819
T + + Q P++++S
Sbjct: 667 APTTRKHQKRHFFDFKVQPEFISSPASDVSQGGGWRCYRGGVVCGGEEPFGEDRLPVVHH 726
Query: 1818 QEDDYVKKLIAEI------KEEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQ------- 1678
QE+ + + L+ + K G + + +++ +E+ + + + G ++
Sbjct: 727 QEEVHQRLLVCGVRGSQGGKYRGEGRGSRRVVLQRAAAEHPRMALHLCGDLLRHDQWSDA 786
Query: 1677 -GIYYPL------------SSQLMIKSYEAYAF--------DKDEMLSKSHFWALSILFL 1561
G+ +PL QL+ + Y + F D + + K+ F++L + +
Sbjct: 787 AGLRHPLLQDHHRRLITLVHEQLVKQIYFPFVFPFQVFVDPDLESVRKKTEFFSLMFVVI 846
Query: 1560 AFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADS 1381
+ +F Q Y FGK+ E L++KLR +F +M ++YDDP +T L+ RL AD+
Sbjct: 847 GCVSFVTMFLQGYCFGKSGEILTLKLRLRAFTAMMRQDLSWYDDPKNTVGALTTRLAADA 906
Query: 1380 SNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQA 1201
+ V A RL ++ + + ++I++F Y W+++L +L PL+ AG +
Sbjct: 907 AQVQGAAGVRLATITQNIANLGTSIIIAFVYGWELTLLILAVVPLIAAAGAAEVKLLAGH 966
Query: 1200 VEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTAN 1021
+D EK+ + A EA+ENVRTV +L+ E + L +L+ + K+A + G
Sbjct: 967 AAKDKKELEKAGKIATEAIENVRTVVSLSREPKFETLYEENLRVPYKNSQKKAHVYGFTY 1026
Query: 1020 GFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAI 841
F+ + +F YA F+FG WL+ + +LV+ + A G A + P++ KA
Sbjct: 1027 SFSQAMIYFAYAACFRFGAWLIEAGRMNVEAVFLVISAVLYGAMAVGEANTFAPNYAKAK 1086
Query: 840 HAAGLIFHLFT-YPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPA 664
AA + L PAI +G + ++V F Y R D IL G++LK+
Sbjct: 1087 MAASYLMMLINKKPAIDNLSEEGVSPGTYDGNVLFESVKFNYPSRPDVPILQGLNLKVKK 1146
Query: 663 GRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVL 484
G TLALVG SG GKST I LLERFY A +G V +D NV ++N+H LR + +VSQEPVL
Sbjct: 1147 GETLALVGSSGCGKSTTIQLLERFYDARNGRVALDGVNVKELNIHWLRSQMGIVSQEPVL 1206
Query: 483 FNCSIKENFLFG-ISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQ 307
F+CS+ EN +G S + + EI A K AN SF+ PQ DT G++G QLSGGQKQ
Sbjct: 1207 FDCSLAENIAYGDNSRSVAMDEIVAAAKAANIHSFIDGLPQKYDTQAGDKGTQLSGGQKQ 1266
Query: 306 RIAIARAILRNPKVLLLDEATSALDSDSEK-------------------------VVQNA 202
RIAIARAI+RNPK+LLLDEATSALD++SEK VVQ A
Sbjct: 1267 RIAIARAIIRNPKLLLLDEATSALDTESEKVSGDSPWVHLTDPSGLYRAGDSRLQVVQEA 1326
Query: 201 LDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
LD A + + +VVAHRLST+ NAD IAV + G V E+GTH++L+ K+ +Y LV KQ
Sbjct: 1327 LDQARKGRTCIVVAHRLSTIQNADCIAVFQGGVVVEKGTHQQLIAKKGVYHMLVTKQ 1383
Score = 296 bits (758), Expect = 3e-78
Identities = 197/549 (35%), Positives = 291/549 (52%), Gaps = 34/549 (6%)
Frame = -1
Query: 3468 LLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGM--STGHLSI 3295
L+F ++G F FLQ G+ +R + + ++R+D+S++D + G L+
Sbjct: 841 LMFVVIGCVSFVTMFLQGYCFGKSGEILTLKLRLRAFTAMMRQDLSWYDDPKNTVGALTT 900
Query: 3294 VLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLLDS 3115
L + + + ++A I + + I+AF W L I +G +
Sbjct: 901 RLAADAAQVQGAAGVRLATITQNIANLGTSIIIAFVYGWELTLLILAVVPLIAAAGAAEV 960
Query: 3114 WGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEEL----KNGEKYAL 2947
+ K + + AG IA +A+ +TV SL+ + + Y E L KN +K A
Sbjct: 961 KLLAGHAAKDKKELEKAGKIATEAIENVRTVVSLSREPKFETLYEENLRVPYKNSQKKAH 1020
Query: 2946 NRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEAI 2767
F +S S++ YF A FGA +I G + V ++ +L+G+ +GEA
Sbjct: 1021 VYGFTYSFSQAMIYFAYAAC----FRFGAWLIEAGRMNVEAVFLVISAVLYGAMAVGEAN 1076
Query: 2766 LHISRLASAIPLTVPIADILLDSDATADEFFSEEIKD-TFQGIISFKNVLFSYPTRPDVP 2590
A A + +L++ D E + T+ G + F++V F+YP+RPDVP
Sbjct: 1077 TFAPNYAKA-KMAASYLMMLINKKPAIDNLSEEGVSPGTYDGNVLFESVKFNYPSRPDVP 1135
Query: 2589 VLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQ 2410
+L+ ++ V+ GE +ALVG+SG GKST IQLL +Y+ +GR+++DG ++ +NI LR
Sbjct: 1136 ILQGLNLKVKKGETLALVGSSGCGKSTTIQLLERFYDARNGRVALDGVNVKELNIHWLRS 1195
Query: 2409 AMGVVFQEPVLFNTSIEENIRFG--KPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGE 2236
MG+V QEPVLF+ S+ ENI +G EI+ A K AN F+ P T G+
Sbjct: 1196 QMGIVSQEPVLFDCSLAENIAYGDNSRSVAMDEIVAAAKAANIHSFIDGLPQKYDTQAGD 1255
Query: 2235 RGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESE-------------------- 2116
+G QLSGGQKQRIAIAR ++RNP++LLLDEATSALD ESE
Sbjct: 1256 KGTQLSGGQKQRIAIARAIIRNPKLLLLDEATSALDTESEKVSGDSPWVHLTDPSGLYRA 1315
Query: 2115 -----FIVQEALQKASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGV 1951
+VQEAL +A GRT IVVAHRLSTI+NA+ I V + G +VE G H+QLIA GV
Sbjct: 1316 GDSRLQVVQEALDQARKGRTCIVVAHRLSTIQNADCIAVFQGGVVVEKGTHQQLIAKKGV 1375
Query: 1950 YNNLVQTQL 1924
Y+ LV Q+
Sbjct: 1376 YHMLVTKQM 1384
>gi|22535563|dbj|BAC10738.1| putative multidrug resistance protein 1
homolog [Oryza sativa (japonica cultivar-group)]
gi|27368857|emb|CAD59586.1| MDR-like ABC transporter [Oryza sativa
(japonica cultivar-group)]
Length = 1274
Score = 706 bits (1822), Expect = 0.0
Identities = 424/1235 (34%), Positives = 676/1235 (54%), Gaps = 28/1235 (2%)
Frame = -1
Query: 3657 LLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFESDMN 3478
LL +G V ++ G+ QP + G+ + TN D+ H +N
Sbjct: 52 LLMAVGTVAALANGVSQPLMTVIFGQVINAFGEATNG---------DVLHR-------VN 95
Query: 3477 RVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFD-GMSTGHL 3301
+ VL F +G A FLQ + G+ A +R Y+ +LR+DI++FD M+TG +
Sbjct: 96 QAVLNFVYLGIATAVVSFLQVACWTMTGERQATRIRSLYLKSVLRQDIAFFDVEMTTGQI 155
Query: 3300 SIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLL 3121
++ + ++ EK+ + L+ F G ++AF W L+ +V++G
Sbjct: 156 VSRMSGDTVLVQDAIGEKVGKFLQLVATFAGGFVVAFVKGWLLSLVMLACIPPVVIAGGA 215
Query: 3120 DSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNR 2941
S K + K S+A ++ Q +G KTV S NG++Q V Y + + K A+
Sbjct: 216 VSKMLAKISSKGQASYSDAANVVEQTIGAIKTVVSFNGEKQAVASYNKLINKAYKAAVEE 275
Query: 2940 AFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEAILH 2761
+ +F + + +++G ++ G ++ IL+ ++ G+ LG A
Sbjct: 276 GLTNGFGMGSVFFIFFSSYGLAIWYGGKLVVSKGYSGGDIINILFAVMTGAMSLGNATPC 335
Query: 2760 ISRLASAIPLTVPI-ADILLDSDATADEFFSEEIKDTFQGIISFKNVLFSYPTRPDVPVL 2584
++ A + I D+ ++++D +G + K+V FSYP RP+ +
Sbjct: 336 MAAFAEGQSAAYRLFKTIKRKPQIDPDDITGKQLED-IRGDVELKDVYFSYPARPEQLIF 394
Query: 2583 KEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAM 2404
S +V G +A+VG SGSGKSTVI L+ +Y+ +G + IDG +I ++ + +R +
Sbjct: 395 DGFSLHVSSGTTMAIVGESGSGKSTVISLVERFYDPQAGEVLIDGINIKSLRLNWIRGKI 454
Query: 2403 GVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGERGAQ 2224
G+V QEP+LF TSI++NI +GK DAT +EI A + ANA +F+ PDG T+VG+RGAQ
Sbjct: 455 GLVSQEPLLFMTSIKDNITYGKEDATIEEIRRAAELANAANFIDKLPDGYDTMVGQRGAQ 514
Query: 2223 LSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHRLS 2044
LSGGQKQRIAIAR +++NP+ILLLDEATSALD ESE IVQEAL + + RTT+VVAHRL+
Sbjct: 515 LSGGQKQRIAIARAILKNPKILLLDEATSALDVESERIVQEALNRIMVDRTTLVVAHRLT 574
Query: 2043 TIRNANKIIVMEKGEIVEVGDHKQLIAM-NGVYNNLVQTQLMSTNYEKMNENEERVTRQS 1867
T+RNA+ I V+++G+IVE G H +L+ NGVY+ L++ Q EK ++ +R
Sbjct: 575 TVRNADCISVVQQGKIVEQGPHDELVMNPNGVYSQLIRLQETHEEEEKKLDHHISDSRSK 634
Query: 1866 SHSDFPSNEISHQKIDQEDDYVKKL-----------------IAEIKEEGA-----KKSN 1753
S S IS + L + E E+G +K+
Sbjct: 635 SRSLSFKRSISRDSAGNSSRHSLALPFGLPGSVELLEGNDSTVGEQTEQGGDGEVQQKAP 694
Query: 1752 ICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWALS 1573
I + + + E IL +A L + + G+ +P+ ++ + + + D++ + FW L
Sbjct: 695 IGRLARLNKPEVPILLLATLAAGVHGVLFPMFGVMISNAIKTFFEPADKLKKDASFWGLM 754
Query: 1572 ILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRL 1393
+ L I I +Y+ FG KL ++R++SF+ ++ A++DDP +++ L RL
Sbjct: 755 CVVLGIISIISIPVEYFMFGIAGGKLVERVRALSFRSIIHQEVAWFDDPRNSSGALGARL 814
Query: 1392 NADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNF 1213
+ D+ NV V D L + + ++ ++++ WK++L +L PL+ L GY F
Sbjct: 815 SVDALNVRRLVGDNLALAVQVVSTLITGIVIAMIADWKLTLIILCVIPLVGLQGYAQVKF 874
Query: 1212 VDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQ 1033
+ E+ + +E +++ A +A+ ++RTV + E RV+ + + + +N + ++
Sbjct: 875 LKGFSEDAKMLYEDASQVATDAVSSIRTVASFCSEKRVMTMYDNKCEASKNQGVRTGMVG 934
Query: 1032 GTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDH 853
G GF+ + Y + F G V + D + V L + A D
Sbjct: 935 GLGFGFSFLMLYLTYGLCFYVGAQFVRHNKTTFGDVFKVFFALVLATIGISQTSAMASDS 994
Query: 852 RKAIHAAGLIFHLFTYPAIMPYDSSQGKR--NIKNGEIELKNVSFEYAQRSDKMILDGVS 679
KA +A IF L + + S +G+ N+K G I+ ++VSF+Y R D I +
Sbjct: 995 TKAKDSAISIFALLDRKSQIDSSSDEGRTLANVK-GNIDFRHVSFKYPTRPDVQIFSDFT 1053
Query: 678 LKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVS 499
L +P+G+T+ALVG SGSGKST I+LLERFY+ G + +DE + ++ ++ LR+ + LV
Sbjct: 1054 LHIPSGKTVALVGESGSGKSTAIALLERFYNPESGTILLDEVEIKNLKVNWLRDQMGLVG 1113
Query: 498 QEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSG 319
QEPVLFN +I+ N +G + ++ E+ +A K +NA F+S PQG DT VGERG QLSG
Sbjct: 1114 QEPVLFNDTIRANIAYGKHGDVTEEELIKAAKASNAHEFISSLPQGYDTTVGERGVQLSG 1173
Query: 318 GQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVV 139
GQKQR+AIARAIL++PK+LLLDEATSALD++SE++VQ+ALD +T++VAHRLST+
Sbjct: 1174 GQKQRVAIARAILKDPKILLLDEATSALDAESERIVQDALDNVMVGRTTIIVAHRLSTIK 1233
Query: 138 NADSIAVLKNGKVAEQGTHEELLR-KRSIYWRLVQ 37
AD IAVLK+G +AE+G HE L+ K +Y LV+
Sbjct: 1234 GADIIAVLKDGAIAEKGRHEALMNIKDGVYASLVE 1268
>gi|283552|pir||S27338 P-glycoprotein C - Caenorhabditis elegans
gi|6811|emb|CAA46191.1| P-glycoprotein C [Caenorhabditis elegans]
Length = 1254
Score = 704 bits (1818), Expect = 0.0
Identities = 421/1236 (34%), Positives = 688/1236 (55%), Gaps = 27/1236 (2%)
Frame = -1
Query: 3657 LLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFESDMN 3478
+LF G++ S + G PF S + L++ + N TI+ F S++
Sbjct: 44 ILFSGGLILSAVNGALVPFNSLIFEGIANALMEGESQYQNGTIN-------MPWFSSEIK 96
Query: 3477 RVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMSTGHLS 3298
L +F +G A F + S + + + + +R++Y+ +LR+D +FD + G L+
Sbjct: 97 MFCLRYFYLGVALFLCSYFANSCLYTLCERRLHCIRKKYLKSVLRQDAKWFDETTIGGLT 156
Query: 3297 IVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLLD 3118
++ +E+ ++ +K+ +++ + F+ G + FY W+L + + + L +
Sbjct: 157 QKMSSGIEKIKDGIGDKVGVLVGGVATFISGVSIGFYMCWQLTLV-MMITVPLQLGSMYL 215
Query: 3117 SWGKMKNNEKQNEH--ISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALN 2944
S K N +NE SNAG +A + + +TV + N Q E+ RY +L + +
Sbjct: 216 S-AKHLNRATKNEMSAYSNAGGMANEVIAGIRTVMAFNAQPFEINRYAHQLNEARRMGIR 274
Query: 2943 RAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEAIL 2764
+A + ++ + V ++GA + G + G V + + +L G+ LGEA
Sbjct: 275 KAIILAICTAFPLMLMFTCMAVAFWYGATLAAAGAVSSGAVFAVFWAVLIGTRRLGEAAP 334
Query: 2763 HISRLASAIPLTVPIADI--LLDSDATADEFFSE-EIKDTFQGIISFKNVLFSYPTRPDV 2593
H+ + A + I DI ++D + SE +I + QG ++F + F+YPTRP++
Sbjct: 335 HLGAITGA---RLAIHDIFKVIDHEPEIKCTSSEGKIPEKIQGKLTFDGIEFTYPTRPEL 391
Query: 2592 PVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLR 2413
+LK +SF V GE +ALVG SG GKST I LL+ +YN +G I +DG I NI+ LR
Sbjct: 392 KILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRWLR 451
Query: 2412 QAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGER 2233
+G+V QEP++F ++ ENIR G T+Q+I +A K ANA +F+C D T++G
Sbjct: 452 STIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIGAG 511
Query: 2232 GAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAH 2053
QLSGGQKQR+AIAR +VR P+ILLLDEATSALD ESE +VQ AL KAS GRTT+ +AH
Sbjct: 512 AVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCIAH 571
Query: 2052 RLSTIRNANKIIVMEKGEIVEVGDHKQLIAM-NGVYNNLVQTQLMSTNYE--KMNENEER 1882
RLSTIRNA+ H +LI+ +G+Y ++V+ Q + E +++ E+
Sbjct: 572 RLSTIRNAS--------------THDELISKDDGIYASMVKAQEIERAKEDTTLDDEEDE 617
Query: 1881 VTRQSSHSDFPSNEIS---HQKIDQEDDYVKKLI----------------AEIKEEGAKK 1759
T +S H D +++ Q + ++ +++ + E+ EEGA +
Sbjct: 618 KTHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPEWEIENAREEMIEEGAME 677
Query: 1758 SNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWA 1579
+++ +I KY E + I+++ + I+G +P S + + ++ + D++ K+ +
Sbjct: 678 ASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIKALLNS 737
Query: 1578 LSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSN 1399
L + LAFT I GK E +S +LR F+++M +++DD H L++
Sbjct: 738 LWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVGSLTS 797
Query: 1398 RLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCND 1219
RL D+ NV AA+D RL V+ +V++ V ++F+Y W M+ L LL +
Sbjct: 798 RLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGLATELLLVVVQSSVA 857
Query: 1218 NFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAV 1039
++ + D + +++R E++ N +TV+AL + + T+ + R +
Sbjct: 858 QYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIVRGL 917
Query: 1038 IQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLP 859
Q + A S + +A+++ FG WL+ P + V+ L+M + A +Y P
Sbjct: 918 WQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAASYFP 977
Query: 858 DHRKAIHAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVS 679
++ +A +AG++F + +++ G G I ++ V F Y R +++LDG +
Sbjct: 978 EYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFAYPNRRRQLVLDGFN 1037
Query: 678 LKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVS 499
+ G+T+ALVGPSG GKST I L+ER+Y A+ G VKID+ ++ D+++ HLR++++LV
Sbjct: 1038 MSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNIALVG 1097
Query: 498 QEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSG 319
QEP LFN +I+EN +G+ N +Q ++++A +AN +FV P G DT VG G +LSG
Sbjct: 1098 QEPTLFNLTIRENITYGL-ENITQDQVEKAATLANIHTFVMGLPDGYDTSVGASGGRLSG 1156
Query: 318 GQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVV 139
GQKQR+AIARAI+R+PK+LLLDEATSALD++SEK+VQ ALD A + VV+AHRLST+
Sbjct: 1157 GQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRLSTIQ 1216
Query: 138 NADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
NAD I V +NGK E+GTH+ LL +R +Y+RLV+KQ
Sbjct: 1217 NADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 1252
>gi|72475|pir||DVMS1A multidrug resistance protein 1a - mouse
(fragment)
gi|200330|gb|AAA03243.1| mdr1a protein
Length = 1104
Score = 704 bits (1816), Expect = 0.0
Identities = 414/1101 (37%), Positives = 618/1101 (55%), Gaps = 16/1101 (1%)
Frame = -1
Query: 3285 DNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLLDSWGK 3106
D++ + E +KI + + F G I+ F W+L + + VL W K
Sbjct: 1 DDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTL--VILAISPVLGLSAGIWAK 58
Query: 3105 MKNN--EKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNRAFV 2932
+ ++ +K+ + AG++A + L +TV + GQ++E+ERY L+ ++ + +A
Sbjct: 59 ILSSFTDKELHAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEAKRLGIKKAIT 118
Query: 2931 FSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEAILHISR 2752
++S A + A + ++G +++ G V+ + + +L G++ +G+A +I
Sbjct: 119 ANISMGAAFLLIYASYALAFWYGTSLVISKEYSIGQVLTVFFSVLIGAFSVGQASPNIEA 178
Query: 2751 LASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPTRPDVPVLKEI 2575
A+A + I+ D+ + D F K D QG + FKN+ FSYP+R +V +LK +
Sbjct: 179 FANARGAAYEVFKII-DNKPSIDSFSKSGHKPDNIQGNLEFKNIHFSYPSRKEVQILKGL 237
Query: 2574 SFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAMGVV 2395
+ V+ G+ +ALVG SG GKST +QL+ Y+ G +SIDG DI IN++ LR+ +GVV
Sbjct: 238 NLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRYLREIIGVV 297
Query: 2394 FQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGERGAQLSG 2215
QEPVLF T+I ENIR+G+ D T EI A+K ANA+DF+ P T+VGERGA +SG
Sbjct: 298 SQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPHQFDTLVGERGAHVSG 357
Query: 2214 GQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHRLSTIR 2035
GQKQRIAIAR LVRNP+ILLLDEATSALD ESE +VQ AL KA GRTTIV+AHRLST+R
Sbjct: 358 GQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVR 417
Query: 2034 NANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNE--------NEERV 1879
NA+ I + G IVE G+H +L+ G+Y LV TQ E NE + +
Sbjct: 418 NADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTAGNEIELGNEACKSKDEIDNLDM 477
Query: 1878 TRQSSHSDFPSNEISHQKIDQEDDYVKKL-IAEIKEEGAKKSNICEIIKYCRSEYCILFI 1702
+ + S S + + I D +KL E +E ++ I+K +E+ +
Sbjct: 478 SSKDSGSSLIRRRSTRKSICGPHDQDRKLSTKEALDEDVPPASFWRILKLNSTEWPYFVV 537
Query: 1701 AVLGSAIQGIYYPLSSQLMIKSYEAY--AFDKDEMLSKSHFWALSILFLAFTRPIFIFFQ 1528
+ + I G P S + K + + S+ ++L L L I F Q
Sbjct: 538 GIFCAIINGGLQPAFSVIFSKVVGVFTNGGPPETQRQNSNLFSLLFLILGIISFITFFLQ 597
Query: 1527 YYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRL 1348
+ FGK E L+ +LR M FK ++ +++DDP +T L+ RL D++ V A RL
Sbjct: 598 GFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGATGSRL 657
Query: 1347 GSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKS 1168
+ + + +I+S Y W+++L +L P++ +AG + +D E S
Sbjct: 658 AVIFQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGS 717
Query: 1167 NRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIY 988
+ A EA+EN RTV +L E + + LQ + K+A + G F + +F Y
Sbjct: 718 GKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNAMKKAHVFGITFSFTQAMMYFSY 777
Query: 987 AVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKA-IHAAGLIFHLF 811
A F+FG +LV ++ + + LV + A G ++ PD+ KA + A+ +I +
Sbjct: 778 AACFRFGAYLVTQQLMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKATVSASHIIRIIE 837
Query: 810 TYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSG 631
P I Y + K N+ G ++ V F Y R +L G+SL++ G+TLALVG SG
Sbjct: 838 KTPEIDSYSTQGLKPNMLEGNVQFSGVVFNYPTRPSIPVLQGLSLEVKKGQTLALVGSSG 897
Query: 630 SGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLF 451
GKST++ LLERFY + G V +D + + +N+ LR + +VSQEP+LF+CSI EN +
Sbjct: 898 CGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAQLGIVSQEPILFDCSIAENIAY 957
Query: 450 G-ISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRN 274
G S S EI +A K AN F+ P +T VG++G QLSGGQKQRIAIARA++R
Sbjct: 958 GDNSRVVSYEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQ 1017
Query: 273 PKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAE 94
P +LLLDEATSALD++SEKVVQ ALD A E + +V+AHRLST+ NAD I V++NGKV E
Sbjct: 1018 PHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGKVKE 1077
Query: 93 QGTHEELLRKRSIYWRLVQKQ 31
GTH++LL ++ IY+ +V Q
Sbjct: 1078 HGTHQQLLAQKGIYFSMVSVQ 1098
Score = 320 bits (820), Expect = 2e-85
Identities = 207/588 (35%), Positives = 329/588 (55%), Gaps = 13/588 (2%)
Frame = -1
Query: 3651 FFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFESDMNRV 3472
F +G+ +I+ G QP S S+V+ TN +T + N
Sbjct: 535 FVVGIFCAIINGGLQPAFSVIF---SKVVGVFTNGGPPETQ------------RQNSNLF 579
Query: 3471 VLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDG--MSTGHLS 3298
LLF ++G F FLQ G+ +R +LR+D+S+FD +TG L+
Sbjct: 580 SLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALT 639
Query: 3297 IVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLLD 3118
L ++ + + ++A+I + + G I++ W+L I ++G+++
Sbjct: 640 TRLANDAAQVKGATGSRLAVIFQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVE 699
Query: 3117 SWGKMKNNE--KQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALN 2944
KM + + K + + +G IA +A+ ++TV SL +Q+ Y + L+ + A+
Sbjct: 700 M--KMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNAMK 757
Query: 2943 RAFVFSLSRSADYFFTNALNF----VILYFGANMIYEGTIEPGVVVRILYYILFGSYCLG 2776
+A VF ++ + FT A+ + FGA ++ + + V+ + I+FG+ +G
Sbjct: 758 KAHVFGIT----FSFTQAMMYFSYAACFRFGAYLVTQQLMTFENVLLVFSAIVFGAMAVG 813
Query: 2775 EAILHISRLASAIPLTVPIADI--LLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPT 2605
+ A A TV + I +++ D + ++ +K + +G + F V+F+YPT
Sbjct: 814 QVSSFAPDYAKA---TVSASHIIRIIEKTPEIDSYSTQGLKPNMLEGNVQFSGVVFNYPT 870
Query: 2604 RPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINI 2425
RP +PVL+ +S V+ G+ +ALVG+SG GKSTV+QLL +Y+ +G + +DG +I +N+
Sbjct: 871 RPSIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNV 930
Query: 2424 KQLRQAMGVVFQEPVLFNTSIEENIRFGKPD--ATEQEIIDALKNANAFDFVCNFPDGIK 2251
+ LR +G+V QEP+LF+ SI ENI +G + +EI+ A K AN F+ + PD
Sbjct: 931 QWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSYEEIVRAAKEANIHQFIDSLPDKYN 990
Query: 2250 TIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRT 2071
T VG++G QLSGGQKQRIAIAR LVR P ILLLDEATSALD ESE +VQEAL KA GRT
Sbjct: 991 TRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRT 1050
Query: 2070 TIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQ 1927
IV+AHRLSTI+NA+ I+V++ G++ E G H+QL+A G+Y ++V Q
Sbjct: 1051 CIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQ 1098
>gi|9961252|ref|NP_061338.1| ATP-binding cassette, subfamily B, member
4 isoform C; P glycoprotein 3/multiple drug resistance 3;
P-glycoprotein-3/multiple drug resistance-3; multiple
drug resistance 3 [Homo sapiens]
Length = 1232
Score = 701 bits (1808), Expect = 0.0
Identities = 429/1232 (34%), Positives = 661/1232 (52%), Gaps = 21/1232 (1%)
Frame = -1
Query: 3663 EKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFESD 3484
+KL LG + +I G P GE + V + + L + K+ E +
Sbjct: 53 DKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEE 112
Query: 3483 MNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMSTGH 3304
M R + +G ++Q S +R+++ +LR++I +FD T
Sbjct: 113 MTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTE 172
Query: 3303 LSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGL 3124
L+ L D++ + E +K+ + + F G I+ F W+L S + LS
Sbjct: 173 LNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAA 232
Query: 3123 LDSWGKMKN--NEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYA 2950
+ W K+ + ++K+ + AG++A +ALG +TV + GQ +E+ERY + L+N ++
Sbjct: 233 V--WAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIG 290
Query: 2949 LNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEA 2770
+ +A ++S + A + ++G+ ++ G + + + IL G++ +G+A
Sbjct: 291 IKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQA 350
Query: 2769 ILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPTRPDV 2593
I A+A I DI+ D++ D F K D+ +G + F +V FSYP+R +V
Sbjct: 351 APCIDAFANARGAAYVIFDII-DNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANV 409
Query: 2592 PVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLR 2413
+LK ++ VQ G+ +ALVG+SG GKST +QL+ Y+ D G I+IDG DI N N+ LR
Sbjct: 410 KILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLR 469
Query: 2412 QAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGER 2233
+ +GVV QEPVLF+T+I ENI +G+ + T EI A+K ANA++F+ P T+VGER
Sbjct: 470 EIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGER 529
Query: 2232 GAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAH 2053
GAQLSGGQKQRIAIAR LVRNP+ILLLDEATSALD ESE VQ AL KA GRTTIV+AH
Sbjct: 530 GAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAH 589
Query: 2052 RLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQ-----TQLMSTNYEKMNEN- 1891
RLST+RNA+ I E G IVE G H +L+ GVY LV +Q+ S +E +E
Sbjct: 590 RLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKA 649
Query: 1890 ---------EERVTRQSSHSDFPSNEISHQKIDQEDDYVKKLIAEIKEEGAKKSNICEII 1738
+ R+ R S+ + ++++ + +D E D ++ + + + +++
Sbjct: 650 ATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPV--------SFLKVL 701
Query: 1737 KYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEM-LSKSHFWALSILFL 1561
K ++E+ + + + G P S + + + D + K + ++L LFL
Sbjct: 702 KLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFL 761
Query: 1560 AFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADS 1381
F Q + FGK E L+ +LRSM+FK ++ +++DD ++ LS RL D+
Sbjct: 762 GIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDA 821
Query: 1380 SNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQA 1201
+ V A RL + + + +I+SF Y W+++L +L P++ ++G +
Sbjct: 822 AQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGN 881
Query: 1200 VEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTAN 1021
+ D E + + A EA+EN+RTV +L E + + +++K+ Y
Sbjct: 882 AKRDKKELEAAGKIATEAIENIRTVVSLTQERK---FESMYVEKLYGPY----------- 927
Query: 1020 GFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAI 841
V + A G A ++ PD+ KA
Sbjct: 928 ---------------------------------RVFSAIVFGAVALGHASSFAPDYAKAK 954
Query: 840 HAAGLIFHLFTYPAIMPYDSSQGKRNIK-NGEIELKNVSFEYAQRSDKMILDGVSLKLPA 664
+A +F LF ++ S +G + K G I V F Y R++ +L G+SL++
Sbjct: 955 LSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKK 1014
Query: 663 GRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVL 484
G+TLALVG SG GKST++ LLERFY + G V +D + +N+ LR + +VSQEP+L
Sbjct: 1015 GQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPIL 1074
Query: 483 FNCSIKENFLFG-ISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQ 307
F+CSI EN +G S SQ EI A K AN F+ P +T VG++G QLSGGQKQ
Sbjct: 1075 FDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQ 1134
Query: 306 RIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADS 127
RIAIARA++R P++LLLDEATSALD++SEKVVQ ALD A E + +V+AHRLST+ NAD
Sbjct: 1135 RIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADL 1194
Query: 126 IAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
I V +NG+V E GTH++LL ++ IY+ +V Q
Sbjct: 1195 IVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ 1226
Score = 332 bits (851), Expect = 4e-89
Identities = 191/511 (37%), Positives = 298/511 (57%), Gaps = 3/511 (0%)
Frame = -1
Query: 1536 FFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVD 1357
+ Q F+ A + K+R F ++ ++D + T L+ RL D S ++ +
Sbjct: 132 YIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFD--INDTTELNTRLTDDISKISEGIG 189
Query: 1356 DRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAF 1177
D++G + I+ F WK++L ++ P+L L+ + +++ A+
Sbjct: 190 DKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAY 249
Query: 1176 EKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYF 997
K+ A EAL +RTV A +N+ + HL+ + K+A+ + G A +
Sbjct: 250 AKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIY 309
Query: 996 FIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFH 817
YA++F +G+ LV+ +E + V ++ + A G A + A AA +IF
Sbjct: 310 ASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFD 369
Query: 816 LF-TYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVG 640
+ P I + K + G +E +V F Y R++ IL G++LK+ +G+T+ALVG
Sbjct: 370 IIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVG 429
Query: 639 PSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKEN 460
SG GKST + L++R Y +G + ID +++ + N+++LRE + +VSQEPVLF+ +I EN
Sbjct: 430 SSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAEN 489
Query: 459 FLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAIL 280
+G N + EI +A+K ANA+ F+ + PQ DTLVGERGAQLSGGQKQRIAIARA++
Sbjct: 490 ICYGRG-NVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALV 548
Query: 279 RNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKV 100
RNPK+LLLDEATSALD++SE VQ ALD A E +T+V+AHRLSTV NAD IA ++G +
Sbjct: 549 RNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVI 608
Query: 99 AEQGTHEELLRKRSIYWRLV--QKQGIQVET 13
EQG+H EL++K +Y++LV Q G Q+++
Sbjct: 609 VEQGSHSELMKKEGVYFKLVNMQTSGSQIQS 639
Score = 298 bits (762), Expect = 9e-79
Identities = 203/586 (34%), Positives = 302/586 (50%), Gaps = 6/586 (1%)
Frame = -1
Query: 3651 FFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFESDMNRV 3472
F +G V +I G QP S E + +A+ + N
Sbjct: 711 FVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVK----------------QQKCNIF 754
Query: 3471 VLLFFLVGF-AYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGM--STGHL 3301
L+F +G ++FTF FLQ G+ +R +LR+D+S+FD STG L
Sbjct: 755 SLIFLFLGIISFFTF-FLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGAL 813
Query: 3300 SIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLL 3121
S L + + + ++ALI + + G I++F W+L I +SG++
Sbjct: 814 STRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIV 873
Query: 3120 DSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNR 2941
+ N ++ + + AG IA +A+ +TV SL +++ Y E+L
Sbjct: 874 EMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKL---------- 923
Query: 2940 AFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEAILH 2761
+G ++ I+FG+ LG A
Sbjct: 924 ------------------------YGPYRVFSA-------------IVFGAVALGHASSF 946
Query: 2760 ISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPTRPDVPVL 2584
A A L+ +L + D + E +K D F+G I+F V+F+YPTR +VPVL
Sbjct: 947 APDYAKA-KLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVL 1005
Query: 2583 KEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAM 2404
+ +S V+ G+ +ALVG+SG GKSTV+QLL +Y+ +G + +DG + +N++ LR +
Sbjct: 1006 QGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQL 1065
Query: 2403 GVVFQEPVLFNTSIEENIRFGKPD--ATEQEIIDALKNANAFDFVCNFPDGIKTIVGERG 2230
G+V QEP+LF+ SI ENI +G ++ EI+ A K AN F+ P +T VG++G
Sbjct: 1066 GIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKG 1125
Query: 2229 AQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHR 2050
QLSGGQKQRIAIAR L+R P+ILLLDEATSALD ESE +VQEAL KA GRT IV+AHR
Sbjct: 1126 TQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHR 1185
Query: 2049 LSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTN 1912
LSTI+NA+ I+V + G + E G H+QL+A G+Y ++V Q + N
Sbjct: 1186 LSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQN 1231
>gi|18496816|gb|AAL74249.1| ABC transporter AbcB2 [Dictyostelium
discoideum]
Length = 1407
Score = 692 bits (1787), Expect = 0.0
Identities = 436/1289 (33%), Positives = 689/1289 (52%), Gaps = 77/1289 (5%)
Frame = -1
Query: 3666 YEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFES 3487
++ LL +G + ++ G+ P S G + P +LA
Sbjct: 135 FDILLMIIGTIGALANGVSMPAISIVFGRLMN------------SFSPENLADPNFDLVE 182
Query: 3486 DMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMSTG 3307
+ + F +G F +++ + G+ A R+ Y+ +L+++I ++D +
Sbjct: 183 TVTSNAMYFIYIGCGVFVCSYVEVAFWMLAGERQAVRCRKAYLKAILKQEIGWYDVTKSS 242
Query: 3306 HLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTD----------WRLACYGT 3157
LS ++ + F+E EKI + + F+ G I+ F W+L
Sbjct: 243 ELSTRISSDTLLFQEAIGEKIGNFLHHTSTFICGFIVGFVNGKNYNYYLFFCWQLTLVIF 302
Query: 3156 VFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTE 2977
+ I +G + +K + + AG +A + +G +TVS+ +G+ EV+RYTE
Sbjct: 303 ALTPLIAAAGAFMTKMMADLTKKGQDAYAKAGGVAEEKIGSIRTVSTFSGEPFEVKRYTE 362
Query: 2976 ELKNGEKYALNRAFVFSLSRSADY---FFTNALNFVILYFGANMIYEGTIEP-------- 2830
LK + + + + F T +L+F ++G +I + P
Sbjct: 363 RLKEALDIGTKKGIMNGIGIGLVFLVLFGTYSLSF---WYGGKLIVDRKWNPVPDRPWQG 419
Query: 2829 GVVVRILYYILFGSYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSE--EIKD 2656
G V+ + + ++ G+ LG+A +++ A+ I +++ D ++ D F +E I++
Sbjct: 420 GDVLTVFFSVIMGAMALGQASPNVASFANGRGAAFKIYEVV-DRNSKIDPFSTEGRSIEE 478
Query: 2655 TFQGIISFKNVLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNI 2476
T QG I ++N+ FSYP+RPDV + + ++ G +ALVG SG GKS+VI LL +Y+
Sbjct: 479 TVQGNIEYRNIGFSYPSRPDVKIFNNFNLTIKKGTTVALVGDSGGGKSSVIGLLERFYDP 538
Query: 2475 DSGRISIDGNDIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKN 2296
D G + +DG +I INI LR+ +G+V QEPVLF SI ENIR+G +AT +II+A K
Sbjct: 539 DEGEVYLDGTNIKEINIHSLRRNIGLVSQEPVLFANSIAENIRYGNENATMDQIIEACKT 598
Query: 2295 ANAFDFVCNFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESE 2116
ANA DF+ P+G T VGE+G Q+SGGQKQRIAIAR ++++P+ILLLDEATSALD+++E
Sbjct: 599 ANAHDFISALPEGYDTQVGEKGVQMSGGQKQRIAIARAMIKDPKILLLDEATSALDSQNE 658
Query: 2115 FIVQEALQKASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLV 1936
+VQ++++K IGRTTIV+AHRLSTI++A++I V++ G IVE+G H +L A+NGVY LV
Sbjct: 659 LLVQQSIEKLMIGRTTIVIAHRLSTIQDADQIAVVKGGAIVEIGTHPELYALNGVYTQLV 718
Query: 1935 QTQLM--STNYEKMNENEERVTRQSSHSDFPSNEISHQKIDQ---------------EDD 1807
Q +K + + ++ S+++ + IS K Q D+
Sbjct: 719 NRQQKGGDDGDKKKKKKSKESSKDESNNNIGPSSISIDKSIQSIGADSLETSTIGLVNDN 778
Query: 1806 YVKKLIAEIKEEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEA 1627
KK + K+ K I I+K R ++ I ++G+ + G P+ S + +
Sbjct: 779 DNKKKKKKEKKPQEKSVPIGRILKLSRGDWPHFLIGLVGATLNGAIMPVFSIIFSEILGI 838
Query: 1626 Y-AFDKDEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSL 1450
+ D DE+ +S AL + LA + F Q Y F EKL+ LR +SF+ +M
Sbjct: 839 FQEQDTDELTRRSRNMALWFILLAVVAALANFIQIYCFTFIGEKLTFNLRRLSFESIMRQ 898
Query: 1449 PCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSL 1270
++D ++ RL+ L +++ V RLG +I +V I+ ++++F WK++L
Sbjct: 899 DIGWFDLTENSTGRLTANLATEATLVQGMTSQRLGLLIQNIVTIVAGLVIAFVSGWKLTL 958
Query: 1269 QVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILL 1090
VL P++ AG +F ++ A+ + + A EA+ +RTV + EN+++
Sbjct: 959 VVLACVPVIGFAGKVEMDFFQGFSQKGKEAYAECGQVASEAIGGIRTVSSFTCENKILEK 1018
Query: 1089 VTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLV------LREEILPMD 928
LQK F+++ + G + GF+ FFIY +++ +G LV +E L
Sbjct: 1019 FRQCLQKPIQMSFRKSNVSGLSFGFSQCTLFFIYTLTYWYGGKLVDSGEWPAKESTLETY 1078
Query: 927 TY-----------------------------LVLMTLSMTASYAGSAVAYLPDHRKAIHA 835
Y V + M+A G ++A++PD KA A
Sbjct: 1079 CYNGEYANIGYTDEATCIKSFTTTEGFSMMMRVFFAIIMSAMGVGQSMAFMPDLGKAKLA 1138
Query: 834 AGLIFHLF-TYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGR 658
A IF L I P+++ G+IE K++ F Y R +K + G +L +P G+
Sbjct: 1139 AVAIFSLIDRVSEIDPFENKGQTLPEFKGDIEFKDIKFSYPSRPNKAVFQGFNLVIPHGK 1198
Query: 657 TLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFN 478
+ALVG SG GKS++ISLLERFY+ G + ID N+ D+NL+ LR ++ LV QEP LF+
Sbjct: 1199 KVALVGNSGGGKSSVISLLERFYNPSQGSITIDGVNIKDLNLNWLRGNMGLVGQEPFLFS 1258
Query: 477 CSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIA 298
+I EN ++G +A+ E+ +A K ANA +F+ P T +G++ QLSGGQKQR+A
Sbjct: 1259 GTIFENIIYG-KPDATMDEVVEAAKAANAHTFIESLPDAYHTQLGDKFTQLSGGQKQRVA 1317
Query: 297 IARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAV 118
IARAI+RNPKVLLLDEATSALD+ SEKVVQ ALD S+ +++V+AHRLSTV++AD I V
Sbjct: 1318 IARAIIRNPKVLLLDEATSALDTVSEKVVQVALDNVSKGRTSIVIAHRLSTVIDADLIVV 1377
Query: 117 LKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
+K GKV E GTHE LL + Y LV +Q
Sbjct: 1378 VKEGKVVELGTHETLLAENGFYAELVSRQ 1406
Score = 304 bits (779), Expect = 1e-80
Identities = 192/563 (34%), Positives = 309/563 (54%), Gaps = 46/563 (8%)
Frame = -1
Query: 3474 VVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFD--GMSTGHL 3301
+ L F L+ F+Q F+G+ +N+RR ++R+DI +FD STG L
Sbjct: 854 MALWFILLAVVAALANFIQIYCFTFIGEKLTFNLRRLSFESIMRQDIGWFDLTENSTGRL 913
Query: 3300 SIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRL-----ACYGTVFSFGIV 3136
+ L + + ++++ L+I + V G ++AF + W+L AC + G V
Sbjct: 914 TANLATEATLVQGMTSQRLGLLIQNIVTIVAGLVIAFVSGWKLTLVVLACVPVIGFAGKV 973
Query: 3135 LSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEK 2956
+ ++K E + G +A +A+G +TVSS + + +E++ + L+ +
Sbjct: 974 EMDFFQGF-----SQKGKEAYAECGQVASEAIGGIRTVSSFTCENKILEKFRQCLQKPIQ 1028
Query: 2955 YALNRAFVFSLS---RSADYFFTNALNFVILYFGANMIYEG-------TIEP-------- 2830
+ ++ V LS FF L + ++G ++ G T+E
Sbjct: 1029 MSFRKSNVSGLSFGFSQCTLFFIYTLTY---WYGGKLVDSGEWPAKESTLETYCYNGEYA 1085
Query: 2829 --------------------GVVVRILYYILFGSYCLGEAILHISRLASAIPLTVPIADI 2710
+++R+ + I+ + +G+++ + L A V I
Sbjct: 1086 NIGYTDEATCIKSFTTTEGFSMMMRVFFAIIMSAMGVGQSMAFMPDLGKAKLAAVAIFS- 1144
Query: 2709 LLDSDATADEFFSE-EIKDTFQGIISFKNVLFSYPTRPDVPVLKEISFNVQGGECIALVG 2533
L+D + D F ++ + F+G I FK++ FSYP+RP+ V + + + G+ +ALVG
Sbjct: 1145 LIDRVSEIDPFENKGQTLPEFKGDIEFKDIKFSYPSRPNKAVFQGFNLVIPHGKKVALVG 1204
Query: 2532 ASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAMGVVFQEPVLFNTSIEEN 2353
SG GKS+VI LL +YN G I+IDG +I ++N+ LR MG+V QEP LF+ +I EN
Sbjct: 1205 NSGGGKSSVISLLERFYNPSQGSITIDGVNIKDLNLNWLRGNMGLVGQEPFLFSGTIFEN 1264
Query: 2352 IRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGERGAQLSGGQKQRIAIARTLVR 2173
I +GKPDAT E+++A K ANA F+ + PD T +G++ QLSGGQKQR+AIAR ++R
Sbjct: 1265 IIYGKPDATMDEVVEAAKAANAHTFIESLPDAYHTQLGDKFTQLSGGQKQRVAIARAIIR 1324
Query: 2172 NPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHRLSTIRNANKIIVMEKGEIV 1993
NP++LLLDEATSALD SE +VQ AL S GRT+IV+AHRLST+ +A+ I+V+++G++V
Sbjct: 1325 NPKVLLLDEATSALDTVSEKVVQVALDNVSKGRTSIVIAHRLSTVIDADLIVVVKEGKVV 1384
Query: 1992 EVGDHKQLIAMNGVYNNLVQTQL 1924
E+G H+ L+A NG Y LV Q+
Sbjct: 1385 ELGTHETLLAENGFYAELVSRQM 1407
>gi|15237456|ref|NP_199466.1| ABC transporter family protein
[Arabidopsis thaliana]
Length = 1248
Score = 692 bits (1785), Expect = 0.0
Identities = 426/1224 (34%), Positives = 672/1224 (54%), Gaps = 24/1224 (1%)
Frame = -1
Query: 3669 RYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFE 3490
RY+ +L +G + ++ G+ QPF S +G+ V D H +K
Sbjct: 29 RYDIVLMVIGTLSAMANGLTQPFMSILMGQLINVF------------GFSDHDHVFK--- 73
Query: 3489 SDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDG-MS 3313
++++V + F + FLQ S G+ + +RR Y+ +LR+DI +FD +
Sbjct: 74 -EVSKVAVKFLYLAAYAGVVSFLQVSCWMVTGERQSTRIRRLYLKTILRQDIGFFDTETN 132
Query: 3312 TGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLA-----CYGTVFS 3148
TG + ++ + ++ EK+ L++ FV G +AF +L C +
Sbjct: 133 TGEVIGRMSGDTILIQDSMGEKVGKFTQLVSSFVGGFTVAFIVGMKLTLALLPCVPLIVG 192
Query: 3147 FGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELK 2968
G ++ ++ K ++ + AG++ QA+G +TV + G++Q + +Y ++L+
Sbjct: 193 TGGAMTYIMS-----KKAQRVQLAYTEAGNVVQQAVGSIRTVVAFTGEKQSMGKYEKKLE 247
Query: 2967 NGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGS 2788
K + + L +++GA I E G V+ ++ IL G
Sbjct: 248 IAYKSMVKQGLYSGLGIGIMMVVVYCTYGFAIWYGARQIIEKGYTGGQVMNVITSILTGG 307
Query: 2787 YCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIKDTFQGIISFKNVLFSYP 2608
LG+ + ++ A+ + + + S E+ + +G I ++V F YP
Sbjct: 308 MALGQTLPSLNSFAAGTAAAYKMFETIKRKPKIDAYDMSGEVLEEIKGDIELRDVYFRYP 367
Query: 2607 TRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNIN 2428
RPDV + S V G +ALVG SGSGKSTVI L+ +Y+ +SG + IDG D+
Sbjct: 368 ARPDVQIFVGFSLTVPNGMTVALVGQSGSGKSTVISLIERFYDPESGEVLIDGIDLKKFQ 427
Query: 2427 IKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKT 2248
+K +R +G+V QEP+LF T+I ENI +GK DA++QEI ALK ANA +F+ P G++T
Sbjct: 428 VKWIRSKIGLVSQEPILFATTIRENIVYGKKDASDQEIRTALKLANASNFIDKLPQGLET 487
Query: 2247 IVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTT 2068
+VGE G QLSGGQKQRIAIAR +++NP+ILLLDEATSALD ESE IVQ+AL K + RTT
Sbjct: 488 MVGEHGTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAESERIVQDALVKLMLSRTT 547
Query: 2067 IVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIA-MNGVYNNLVQTQLMSTNYEKMNEN 1891
+VVAHRL+TIR A+ I V+++G+++E G H ++I G Y+ LV+ Q S E +++
Sbjct: 548 VVVAHRLTTIRTADMIAVVQQGKVIEKGTHDEMIKDPEGTYSQLVRLQEGSKKEEAIDKE 607
Query: 1890 EERV----------TRQSSHS---DFPSNEISHQKIDQEDDYVKKLIAEIKEEGAKKS-- 1756
E+ ++ HS PS +DQ +++ + I+ K + KK
Sbjct: 608 PEKCEMSLEIESSDSQNGIHSGTLTSPSGLPGVISLDQTEEFHEN-ISSTKTQTVKKGKE 666
Query: 1755 -NICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWA 1579
++ + + E +L + L + I GI +P+ L+ ++ + +++ + S FWA
Sbjct: 667 VSLRRLAHLNKPEISVLLLGSLAAVIHGIVFPVQGLLLSRTIRIFFEPSNKLKNDSLFWA 726
Query: 1578 LSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSN 1399
L + L T I I Q Y F KL ++RS+SF ++ +++DD +++ +
Sbjct: 727 LIFVALGLTDLIVIPLQNYLFAIAGAKLIKRIRSLSFDRVLHQDISWFDDTKNSSGVIGA 786
Query: 1398 RLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCND 1219
RL+ D+S V + V D LG ++ + I+ A I++F +W ++L L+ P+++ GY
Sbjct: 787 RLSTDASTVKSIVGDVLGLIMQNMATIIGAFIIAFTANWLLALMALLVAPVMFFQGYYQI 846
Query: 1218 NFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAV 1039
F+ + +E++++ A +A+ ++RTV + E++V+ L + + FK +
Sbjct: 847 KFITGFGAKARGKYEEASQVASDAVSSIRTVASFCAEDKVMDLYQEKCDEPKQQGFKLGL 906
Query: 1038 IQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLP 859
+ G G + + I +V F G+WL+ + + V L++TA P
Sbjct: 907 VSGLCYGGSYLALYVIESVCFLGGSWLIQNRRATFGEFFQVFFALTLTAVGVTQTSTMAP 966
Query: 858 DHRKAIHAAGLIFHLFTYPAIMPYDSSQGK-RNIKNGEIELKNVSFEYAQRSDKMILDGV 682
D KA +A IF + + S +G I +G+IEL++VSF Y R D I +
Sbjct: 967 DINKAKDSAASIFDILDSKPKIDSSSEKGTILPIVHGDIELQHVSFRYPMRPDIQIFSDL 1026
Query: 681 SLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLV 502
L + +G+T+ALVG SGSGKST+ISLLERFY G++ +D+ + + L LRE + LV
Sbjct: 1027 CLTISSGQTVALVGESGSGKSTVISLLERFYDPDSGKILLDQVEIQSLKLSWLREQMGLV 1086
Query: 501 SQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLS 322
SQEPVLFN +I N +G A++ EI A K AN +F+S PQG +T VGERG QLS
Sbjct: 1087 SQEPVLFNETIGSNIAYGKIGGATEEEIITAAKAANVHNFISSLPQGYETSVGERGVQLS 1146
Query: 321 GGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTV 142
GGQKQRIAIARAIL++PK+LLLDEATSALD++SE+VVQ+ALD +TVVVAH L+T+
Sbjct: 1147 GGQKQRIAIARAILKDPKILLLDEATSALDAESERVVQDALDQVMVNRTTVVVAHLLTTI 1206
Query: 141 VNADSIAVLKNGKVAEQGTHEELL 70
+AD IAV+KNG +AE G HE L+
Sbjct: 1207 KDADMIAVVKNGVIAESGRHETLM 1230
Score = 306 bits (784), Expect = 3e-81
Identities = 195/569 (34%), Positives = 305/569 (53%), Gaps = 3/569 (0%)
Frame = -1
Query: 1728 RSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAF-DKDEMLSKSHFWALSILFLAFT 1552
R + ++ I L + G+ P S LM + + F D D + + A+ L+LA
Sbjct: 29 RYDIVLMVIGTLSAMANGLTQPFMSILMGQLINVFGFSDHDHVFKEVSKVAVKFLYLAAY 88
Query: 1551 RPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNV 1372
+ F Q + T E+ S ++R + K ++ F+D +T + R++ D+ +
Sbjct: 89 AGVVSFLQVSCWMVTGERQSTRIRRLYLKTILRQDIGFFDTETNTG-EVIGRMSGDTILI 147
Query: 1371 TAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEE 1192
++ +++G + + + ++F K++L +L PL+ G + + +
Sbjct: 148 QDSMGEKVGKFTQLVSSFVGGFTVAFIVGMKLTLALLPCVPLIVGTGGAMTYIMSKKAQR 207
Query: 1191 DSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFA 1012
+A+ ++ +A+ ++RTV A E + + L+ S K+ + G G
Sbjct: 208 VQLAYTEAGNVVQQAVGSIRTVVAFTGEKQSMGKYEKKLEIAYKSMVKQGLYSGLGIGIM 267
Query: 1011 CSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAA 832
+ Y + +G ++ + V+ ++ G + L AA
Sbjct: 268 MVVVYCTYGFAIWYGARQIIEKGYTGGQVMNVITSILTGGMALGQTLPSLNSFAAGTAAA 327
Query: 831 GLIFHLFTY-PAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRT 655
+F P I YD S G+IEL++V F Y R D I G SL +P G T
Sbjct: 328 YKMFETIKRKPKIDAYDMSGEVLEEIKGDIELRDVYFRYPARPDVQIFVGFSLTVPNGMT 387
Query: 654 LALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNC 475
+ALVG SGSGKST+ISL+ERFY GEV ID ++ + +R + LVSQEP+LF
Sbjct: 388 VALVGQSGSGKSTVISLIERFYDPESGEVLIDGIDLKKFQVKWIRSKIGLVSQEPILFAT 447
Query: 474 SIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAI 295
+I+EN ++G +AS EI ALK+ANA +F+ + PQGL+T+VGE G QLSGGQKQRIAI
Sbjct: 448 TIRENIVYG-KKDASDQEIRTALKLANASNFIDKLPQGLETMVGEHGTQLSGGQKQRIAI 506
Query: 294 ARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVL 115
ARAIL+NPK+LLLDEATSALD++SE++VQ+AL +TVVVAHRL+T+ AD IAV+
Sbjct: 507 ARAILKNPKILLLDEATSALDAESERIVQDALVKLMLSRTTVVVAHRLTTIRTADMIAVV 566
Query: 114 KNGKVAEQGTHEELLR-KRSIYWRLVQKQ 31
+ GKV E+GTH+E+++ Y +LV+ Q
Sbjct: 567 QQGKVIEKGTHDEMIKDPEGTYSQLVRLQ 595
Score = 278 bits (712), Expect = 6e-73
Identities = 186/578 (32%), Positives = 293/578 (50%), Gaps = 5/578 (0%)
Frame = -1
Query: 3654 LFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFESDMNR 3475
+ LG + +++ G+ P + L T ++ + +N + N + LF +
Sbjct: 682 VLLLGSLAAVIHGIVFPVQGLLLSRTIRIFFEPSNKLKNDS-----------LFWA---- 726
Query: 3474 VVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGM--STGHL 3301
L+F +G LQ + G +R R+L +DIS+FD S+G +
Sbjct: 727 --LIFVALGLTDLIVIPLQNYLFAIAGAKLIKRIRSLSFDRVLHQDISWFDDTKNSSGVI 784
Query: 3300 SIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLL 3121
L+ + + + + + LI+ + + I+AF +W LA + + + G
Sbjct: 785 GARLSTDASTVKSIVGDVLGLIMQNMATIIGAFIIAFTANWLLALMALLVAPVMFFQGYY 844
Query: 3120 DSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNR 2941
K A +A A+ +TV+S + + ++ Y E+ ++
Sbjct: 845 QIKFITGFGAKARGKYEEASQVASDAVSSIRTVASFCAEDKVMDLYQEKCDEPKQQGFKL 904
Query: 2940 AFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEAILH 2761
V L Y + V G+ +I G ++ + + + + +
Sbjct: 905 GLVSGLCYGGSYLALYVIESVCFLGGSWLIQNRRATFGEFFQVFFALTLTAVGVTQTSTM 964
Query: 2760 ISRLASAIPLTVPIADILLDSDATADEFFSE-EIKDTFQGIISFKNVLFSYPTRPDVPVL 2584
+ A I DIL DS D + I G I ++V F YP RPD+ +
Sbjct: 965 APDINKAKDSAASIFDIL-DSKPKIDSSSEKGTILPIVHGDIELQHVSFRYPMRPDIQIF 1023
Query: 2583 KEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAM 2404
++ + G+ +ALVG SGSGKSTVI LL +Y+ DSG+I +D +I ++ + LR+ M
Sbjct: 1024 SDLCLTISSGQTVALVGESGSGKSTVISLLERFYDPDSGKILLDQVEIQSLKLSWLREQM 1083
Query: 2403 GVVFQEPVLFNTSIEENIRFGK-PDATEQEIIDALKNANAFDFVCNFPDGIKTIVGERGA 2227
G+V QEPVLFN +I NI +GK ATE+EII A K AN +F+ + P G +T VGERG
Sbjct: 1084 GLVSQEPVLFNETIGSNIAYGKIGGATEEEIITAAKAANVHNFISSLPQGYETSVGERGV 1143
Query: 2226 QLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHRL 2047
QLSGGQKQRIAIAR ++++P+ILLLDEATSALD ESE +VQ+AL + + RTT+VVAH L
Sbjct: 1144 QLSGGQKQRIAIARAILKDPKILLLDEATSALDAESERVVQDALDQVMVNRTTVVVAHLL 1203
Query: 2046 STIRNANKIIVMEKGEIVEVGDHKQLIAMN-GVYNNLV 1936
+TI++A+ I V++ G I E G H+ L+ ++ G Y +LV
Sbjct: 1204 TTIKDADMIAVVKNGVIAESGRHETLMEISGGAYASLV 1241
>gi|13929072|ref|NP_113948.1| ATP-binding cassette, sub-family B
(MDR/TAP), member 11; sister of P-glycoprotein; bile salt
export pump [Rattus norvegicus]
gi|12585136|sp|O70127|AB11_RAT Bile salt export pump (ATP-binding
cassette, sub-family B, member 11) (Sister of
P-glycoprotein)
gi|11346285|pir||T42842 bile salt transport protein, ATP-dependent -
rat
gi|3075422|gb|AAC40084.1| bile salt export pump [Rattus norvegicus]
Length = 1321
Score = 691 bits (1782), Expect = 0.0
Identities = 434/1260 (34%), Positives = 670/1260 (52%), Gaps = 55/1260 (4%)
Frame = -1
Query: 3654 LFFLGVVFSILTGMCQPFESYTLGETSQVLVKVT----------NAINNKTIDPVDLAHA 3505
L +G V ++L GM QP G + + +K A N TI ++ +
Sbjct: 61 LMLMGGVCALLHGMAQPGILIIFGIMTDIFIKYDIERQELEIPGKACVNNTIVWINSSFH 120
Query: 3504 YKL----------FESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYIS 3355
+ ES+M + ++ VG G+ Q + G +R+ Y
Sbjct: 121 QNMTNGTVCGLVDIESEMIKFSGIYAGVGMTVLILGYFQIRLWVITGARQIRRMRKIYFR 180
Query: 3354 RLLRKDISYFDGMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWR 3175
R++R +I +FD S G L+ D++E+ + +++A + ++ + G +L FY W+
Sbjct: 181 RIMRMEIGWFDCTSVGELNSRFADDIEKINDAIADQLAHFLQRMSTAMCGLLLGFYRGWK 240
Query: 3174 LACYGTVFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQE 2995
L S I + + K E + + + AGSIA + L +TV++ G+ +E
Sbjct: 241 LTLVILAVSPLIGIGAAVIGLSIAKFTELELKAYAKAGSIADEVLSSIRTVAAFGGENKE 300
Query: 2994 VERYTEELKNGEKYALNRAFVFSLSRSADY---FFTNALNFVILYFGANMIY-EGTIEPG 2827
VERY + L +++ + + V + FF AL F ++G+ ++ E PG
Sbjct: 301 VERYEKNLVFAQRWGIWKGMVMGFFTGYMWCLIFFCYALAF---WYGSTLVLDEEEYTPG 357
Query: 2826 VVVRILYYILFGSYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTF 2650
+V+I ++ + +G A + ++ I + D D + K D
Sbjct: 358 TLVQIFLCVILAAMNIGHASSCLEIFSTGCSAATNIFQTI-DRQPVIDCMSGDGYKLDRI 416
Query: 2649 QGIISFKNVLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDS 2470
+G I F NV F YP+RPDV +L +S ++ GE ALVG+SG+GKST +QL+ +Y+
Sbjct: 417 KGEIEFHNVTFHYPSRPDVKILDNLSMVIKPGETTALVGSSGAGKSTALQLIQRFYDPCE 476
Query: 2469 GRISIDGNDIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNAN 2290
G +++DG+DI ++NI+ LR +G+V QEPVLF+T+I ENIRFG+ DAT ++I+ A K+AN
Sbjct: 477 GMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAENIRFGREDATMEDIVQAAKDAN 536
Query: 2289 AFDFVCNFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFI 2110
A++F+ P T+VGE G Q+SGGQKQR+AIAR L+RNP+ILLLD ATSALDNESE
Sbjct: 537 AYNFIMALPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAR 596
Query: 2109 VQEALQKASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQT 1930
VQEAL K G T I VAHRLST+R A+ II E G VE G H++L+ GVY LV
Sbjct: 597 VQEALNKIQHGHTIISVAHRLSTVRAADVIIGFEHGVAVERGTHEELLERKGVYFMLVTL 656
Query: 1929 QLMSTNYEKMNE----------NEERVTRQSSHSDFPSNEISHQK--------------- 1825
Q N K ER + S+ D I +
Sbjct: 657 QSQGDNAHKETSIMGKDATEGGTLERTFSRGSYRDSLRASIRQRSKSQLSLLTHDPPLAV 716
Query: 1824 IDQEDDYVKKLIAEIKEEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLM 1645
D + Y ++ E + + + I+KY E+ + + L +AI G P+ S L
Sbjct: 717 ADHKSSYKDSKDNDVLVEEVEPAPVRRILKYNIPEWHYILVGSLSAAINGAVTPIYSLLF 776
Query: 1644 IKSYEAYA-FDKDEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSF 1468
+ ++ DK++ S+ H L + L F Q Y F K+ E L+ +LR F
Sbjct: 777 SQLLGTFSLLDKEQQRSEIHSMCLFFVILGCVSIFTQFLQGYTFAKSGELLTKRLRKFGF 836
Query: 1467 KHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFY 1288
K ++ ++DD + L+ RL D+S V A ++G ++ + I+ A++++FF+
Sbjct: 837 KAMLGQDIGWFDDLRNNPGVLTTRLATDASQVQGATGSQVGMMVNSFTNIIAALLIAFFF 896
Query: 1287 SWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNME 1108
SWK+SL + +F P L L+G + +D A EK+ + EAL N+RTV + +E
Sbjct: 897 SWKLSLIITIFFPFLALSGAVQTKMLTGFASQDKQALEKAGQITSEALSNIRTVAGIGVE 956
Query: 1107 NRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMD 928
R I LQ + ++A I G F+ F + ++++G +L+ E +
Sbjct: 957 GRFIKAFEVELQTSYKTAVRKANIYGLCFAFSQGIAFLANSAAYRYGGYLIAYEGLGFSH 1016
Query: 927 TYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFHLF-TYPAIMPYDSSQGKRNIKNG 751
+ V+ +++++A+ G +Y P + KA +A F L P I Y + K + G
Sbjct: 1017 VFRVVSSVALSATAVGRTFSYTPSYAKAKISAARFFQLLDRKPPINVYSEAGEKWDNFQG 1076
Query: 750 EIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGE 571
+I+ + F Y R D +L+G+S+ + G+TLA VG SG GKST I LLERFY G
Sbjct: 1077 KIDFIDCKFTYPSRPDIQVLNGLSVSVNPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGT 1136
Query: 570 VKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQAL---KV 400
V ID + VN+ LR ++ +VSQEPVLF+CSI +N +G N ++ +++A+ K
Sbjct: 1137 VMIDGHDSKKVNIQFLRSNIGIVSQEPVLFDCSIMDNIKYG--DNTKEISVERAIAAAKQ 1194
Query: 399 ANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSE 220
A FV P+ +T VG +G+QLS G+KQRIAIARAI+R+PK+LLLDEATSALD++SE
Sbjct: 1195 AQLHDFVMSLPEKYETNVGIQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESE 1254
Query: 219 KVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLV 40
K VQ ALD A E + +V+AHRLST+ N+D IAV+ G V E+GTHE+L+ ++ Y++LV
Sbjct: 1255 KTVQTALDKAREGRTCIVIAHRLSTIQNSDIIAVVSQGVVIEKGTHEKLMAQKGAYYKLV 1314
Score = 306 bits (785), Expect = 2e-81
Identities = 184/507 (36%), Positives = 282/507 (55%), Gaps = 4/507 (0%)
Frame = -1
Query: 1536 FFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVD 1357
+FQ + T + ++R + F+ +M + ++D C + L++R D + A+
Sbjct: 157 YFQIRLWVITGARQIRRMRKIYFRRIMRMEIGWFD--CTSVGELNSRFADDIEKINDAIA 214
Query: 1356 DRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAF 1177
D+L + + + +++ F+ WK++L +L PL+ + + + E + A+
Sbjct: 215 DQLAHFLQRMSTAMCGLLLGFYRGWKLTLVILAVSPLIGIGAAVIGLSIAKFTELELKAY 274
Query: 1176 EKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYF 997
K+ A E L ++RTV A EN+ + +L + + ++ G G+ F
Sbjct: 275 AKAGSIADEVLSSIRTVAAFGGENKEVERYEKNLVFAQRWGIWKGMVMGFFTGYMWCLIF 334
Query: 996 FIYAVSFKFGTWLVL-REEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIF 820
F YA++F +G+ LVL EE P + + + + A G A + L AA IF
Sbjct: 335 FCYALAFWYGSTLVLDEEEYTPGTLVQIFLCVILAAMNIGHASSCLEIFSTGCSAATNIF 394
Query: 819 HLFTYPAIMPYDSSQG-KRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALV 643
++ S G K + GEIE NV+F Y R D ILD +S+ + G T ALV
Sbjct: 395 QTIDRQPVIDCMSGDGYKLDRIKGEIEFHNVTFHYPSRPDVKILDNLSMVIKPGETTALV 454
Query: 642 GPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKE 463
G SG+GKST + L++RFY +G V +D ++ +N+ LR+ + +V QEPVLF+ +I E
Sbjct: 455 GSSGAGKSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAE 514
Query: 462 NFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAI 283
N FG +A+ +I QA K ANA++F+ PQ DTLVGE G Q+SGGQKQR+AIARA+
Sbjct: 515 NIRFG-REDATMEDIVQAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQKQRVAIARAL 573
Query: 282 LRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGK 103
+RNPK+LLLD ATSALD++SE VQ AL+ + + VAHRLSTV AD I ++G
Sbjct: 574 IRNPKILLLDMATSALDNESEARVQEALNKIQHGHTIISVAHRLSTVRAADVIIGFEHGV 633
Query: 102 VAEQGTHEELLRKRSIYWRLV--QKQG 28
E+GTHEELL ++ +Y+ LV Q QG
Sbjct: 634 AVERGTHEELLERKGVYFMLVTLQSQG 660
Score = 291 bits (744), Expect = 1e-76
Identities = 192/572 (33%), Positives = 306/572 (52%), Gaps = 17/572 (2%)
Frame = -1
Query: 3594 YTLGETSQVLVKVTNAINNKTIDPV------DLAHAYKLFESDMNR-----VVLLFFLVG 3448
Y + E +LV +A N + P+ L + L + + R + L F ++G
Sbjct: 747 YNIPEWHYILVGSLSAAINGAVTPIYSLLFSQLLGTFSLLDKEQQRSEIHSMCLFFVILG 806
Query: 3447 FAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGM--STGHLSIVLNDNME 3274
FLQ G+ +R+ +L +DI +FD + + G L+ L +
Sbjct: 807 CVSIFTQFLQGYTFAKSGELLTKRLRKFGFKAMLGQDIGWFDDLRNNPGVLTTRLATDAS 866
Query: 3273 RFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLLDSWGKMKNN 3094
+ + ++ +++ T+ + ++AF+ W+L+ T+F + LSG + +
Sbjct: 867 QVQGATGSQVGMMVNSFTNIIAALLIAFFFSWKLSLIITIFFPFLALSGAVQTKMLTGFA 926
Query: 3093 EKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNRAFVFSLSRS 2914
+ + + AG I +AL +TV+ + + + ++ + EL+ K A+ +A ++ L +
Sbjct: 927 SQDKQALEKAGQITSEALSNIRTVAGIGVEGRFIKAFEVELQTSYKTAVRKANIYGLCFA 986
Query: 2913 ADYFFTNALNFVILYFGANMI-YEGTIEPGVVVRILYYILFGSYCLGEAILHISRLASAI 2737
N +G +I YEG + V R++ + + +G + A A
Sbjct: 987 FSQGIAFLANSAAYRYGGYLIAYEG-LGFSHVFRVVSSVALSATAVGRTFSYTPSYAKA- 1044
Query: 2736 PLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPTRPDVPVLKEISFNVQ 2560
++ LLD + + K D FQG I F + F+YP+RPD+ VL +S +V
Sbjct: 1045 KISAARFFQLLDRKPPINVYSEAGEKWDNFQGKIDFIDCKFTYPSRPDIQVLNGLSVSVN 1104
Query: 2559 GGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAMGVVFQEPV 2380
G+ +A VG+SG GKST IQLL +Y+ D G + IDG+D +NI+ LR +G+V QEPV
Sbjct: 1105 PGQTLAFVGSSGCGKSTSIQLLERFYDPDQGTVMIDGHDSKKVNIQFLRSNIGIVSQEPV 1164
Query: 2379 LFNTSIEENIRFGK--PDATEQEIIDALKNANAFDFVCNFPDGIKTIVGERGAQLSGGQK 2206
LF+ SI +NI++G + + + I A K A DFV + P+ +T VG +G+QLS G+K
Sbjct: 1165 LFDCSIMDNIKYGDNTKEISVERAIAAAKQAQLHDFVMSLPEKYETNVGIQGSQLSRGEK 1224
Query: 2205 QRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHRLSTIRNAN 2026
QRIAIAR +VR+P+ILLLDEATSALD ESE VQ AL KA GRT IV+AHRLSTI+N++
Sbjct: 1225 QRIAIARAIVRDPKILLLDEATSALDTESEKTVQTALDKAREGRTCIVIAHRLSTIQNSD 1284
Query: 2025 KIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQT 1930
I V+ +G ++E G H++L+A G Y LV T
Sbjct: 1285 IIAVVSQGVVIEKGTHEKLMAQKGAYYKLVIT 1316
>gi|7514034|pir||T42228 P-glycoprotein sister - rat
gi|3273484|gb|AAC24753.1| P-glycoprotein sister [Rattus norvegicus]
Length = 1321
Score = 689 bits (1779), Expect = 0.0
Identities = 434/1260 (34%), Positives = 669/1260 (52%), Gaps = 55/1260 (4%)
Frame = -1
Query: 3654 LFFLGVVFSILTGMCQPFESYTLGETSQVLVKVT----------NAINNKTIDPVDLAHA 3505
L +G V ++L GM QP G + + +K A N TI ++ +
Sbjct: 61 LMLMGGVCALLHGMAQPGILIIFGIMTDIFIKYDIERQELEIPGKACVNNTIVWINSSFH 120
Query: 3504 YKL----------FESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYIS 3355
+ ES+M + ++ VG G+ Q + G +R+ Y
Sbjct: 121 QNMTNGTVCGLVDIESEMIKFSGIYAGVGMTVLILGYFQIRLWVITGARQIRRMRKIYFR 180
Query: 3354 RLLRKDISYFDGMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWR 3175
R++R +I +FD S G L+ D++E+ + +++A + ++ + G +L FY W+
Sbjct: 181 RIMRMEIGWFDCTSVGELNSRFADDIEKINDAIADQLAHFLQRMSTAMCGLLLGFYRGWK 240
Query: 3174 LACYGTVFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQE 2995
L S I + + K E + + + AGSIA + L +TV++ G+ +E
Sbjct: 241 LTLVILAVSPLIGIGAAVIGLSIAKFTELELKAYAKAGSIADEVLSSIRTVAAFGGENKE 300
Query: 2994 VERYTEELKNGEKYALNRAFVFSLSRSADY---FFTNALNFVILYFGANMIY-EGTIEPG 2827
VERY + L +++ + + V + FF AL F ++G+ ++ E PG
Sbjct: 301 VERYEKNLVFAQRWGIWKGMVMGFFTGYMWCLIFFCYALAF---WYGSTLVLDEEEYTPG 357
Query: 2826 VVVRILYYILFGSYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTF 2650
+V+I ++ + +G A + ++ I + D D + K D
Sbjct: 358 TLVQIFLCVILAAMNIGHASSCLEIFSTGCSAATNIFQTI-DRQPVIDCMSGDGYKLDRI 416
Query: 2649 QGIISFKNVLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDS 2470
+G I F NV F YP+RPDV +L +S ++ GE ALVG+SG+GKST +QL+ +Y+
Sbjct: 417 KGEIEFHNVTFHYPSRPDVKILDNLSMVIKPGETTALVGSSGAGKSTALQLIQRFYDPCE 476
Query: 2469 GRISIDGNDIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNAN 2290
G +++DG+DI ++NI+ LR +G+V QEPVLF+T+I ENIRFG+ DAT ++I+ A K+AN
Sbjct: 477 GMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAENIRFGREDATMEDIVQAAKDAN 536
Query: 2289 AFDFVCNFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFI 2110
A++F+ P T+VGE G Q+SGGQKQR+AIAR L+RNP+ILLLD ATSALDNESE
Sbjct: 537 AYNFIMALPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAR 596
Query: 2109 VQEALQKASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQT 1930
VQEAL K G T I VAHRLST+R A+ II E G VE G H++L+ GVY LV
Sbjct: 597 VQEALNKIQHGHTIISVAHRLSTVRAADVIIGFEHGVAVERGTHEELLERKGVYFMLVTL 656
Query: 1929 QLMSTNYEKMNE----------NEERVTRQSSHSDFPSNEISHQK--------------- 1825
Q N K ER + S+ D I +
Sbjct: 657 QSQGDNAHKETSIMGKDATEGGTLERTFSRGSYRDSLRASIRQRSKSQLSLLTHDPPLAV 716
Query: 1824 IDQEDDYVKKLIAEIKEEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLM 1645
D + Y ++ E + + + I+KY E+ + + L +AI G P+ S L
Sbjct: 717 ADHKSSYKDSKDNDVLVEEVEPAPVRRILKYNIPEWHYILVGSLSAAINGAVTPIYSLLF 776
Query: 1644 IKSYEAYA-FDKDEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSF 1468
+ ++ DK++ S+ H L + L F Q Y F K+ E L+ +LR F
Sbjct: 777 SQLLGTFSLLDKEQQRSEIHSMCLFFVILGCVSIFTQFLQGYTFAKSGELLTKRLRKFGF 836
Query: 1467 KHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFY 1288
K ++ ++DD + L+ RL D+S V A ++G ++ + I+ A++++FF+
Sbjct: 837 KAMLGQDIGWFDDLRNNPGVLTTRLATDASQVQGATGSQVGMMVNSFTNIIAALLIAFFF 896
Query: 1287 SWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNME 1108
SWK+SL + +F P L L+G + +D A EK+ + EAL N+RTV + +E
Sbjct: 897 SWKLSLIITIFFPFLALSGAVQTKMLTGFASQDKQALEKAGQITSEALSNIRTVAGIGVE 956
Query: 1107 NRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMD 928
R I LQ + ++A I G F+ F + ++++G +L+ E +
Sbjct: 957 GRFIKAFEVELQTSYKTAVRKANIYGLCFAFSQGIAFLANSAAYRYGGYLIAYEGLGFSH 1016
Query: 927 TYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFHLF-TYPAIMPYDSSQGKRNIKNG 751
+ V+ ++ ++A+ G +Y P + KA +A F L P I Y + K + G
Sbjct: 1017 VFRVVSSVVLSATAVGRTFSYTPSYAKAKISAARFFQLLDRKPPINVYSEAGEKWDNFQG 1076
Query: 750 EIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGE 571
+I+ + F Y R D +L+G+S+ + G+TLA VG SG GKST I LLERFY G
Sbjct: 1077 KIDFIDCKFTYPSRPDIQVLNGLSVSVNPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGT 1136
Query: 570 VKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQAL---KV 400
V ID + VN+ LR ++ +VSQEPVLF+CSI +N +G N ++ +++A+ K
Sbjct: 1137 VMIDGHDSKKVNIQFLRSNIGIVSQEPVLFDCSIMDNIKYG--DNTKEISVERAIAAAKQ 1194
Query: 399 ANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSE 220
A FV P+ +T VG +G+QLS G+KQRIAIARAI+R+PK+LLLDEATSALD++SE
Sbjct: 1195 AQLHDFVMSLPEKYETNVGIQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESE 1254
Query: 219 KVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLV 40
K VQ ALD A E + +V+AHRLST+ N+D IAV+ G V E+GTHE+L+ ++ Y++LV
Sbjct: 1255 KTVQTALDKAREGRTCIVIAHRLSTIQNSDIIAVVSQGVVIEKGTHEKLMAQKGAYYKLV 1314
Score = 306 bits (785), Expect = 2e-81
Identities = 184/507 (36%), Positives = 282/507 (55%), Gaps = 4/507 (0%)
Frame = -1
Query: 1536 FFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVD 1357
+FQ + T + ++R + F+ +M + ++D C + L++R D + A+
Sbjct: 157 YFQIRLWVITGARQIRRMRKIYFRRIMRMEIGWFD--CTSVGELNSRFADDIEKINDAIA 214
Query: 1356 DRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAF 1177
D+L + + + +++ F+ WK++L +L PL+ + + + E + A+
Sbjct: 215 DQLAHFLQRMSTAMCGLLLGFYRGWKLTLVILAVSPLIGIGAAVIGLSIAKFTELELKAY 274
Query: 1176 EKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYF 997
K+ A E L ++RTV A EN+ + +L + + ++ G G+ F
Sbjct: 275 AKAGSIADEVLSSIRTVAAFGGENKEVERYEKNLVFAQRWGIWKGMVMGFFTGYMWCLIF 334
Query: 996 FIYAVSFKFGTWLVL-REEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIF 820
F YA++F +G+ LVL EE P + + + + A G A + L AA IF
Sbjct: 335 FCYALAFWYGSTLVLDEEEYTPGTLVQIFLCVILAAMNIGHASSCLEIFSTGCSAATNIF 394
Query: 819 HLFTYPAIMPYDSSQG-KRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALV 643
++ S G K + GEIE NV+F Y R D ILD +S+ + G T ALV
Sbjct: 395 QTIDRQPVIDCMSGDGYKLDRIKGEIEFHNVTFHYPSRPDVKILDNLSMVIKPGETTALV 454
Query: 642 GPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKE 463
G SG+GKST + L++RFY +G V +D ++ +N+ LR+ + +V QEPVLF+ +I E
Sbjct: 455 GSSGAGKSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAE 514
Query: 462 NFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAI 283
N FG +A+ +I QA K ANA++F+ PQ DTLVGE G Q+SGGQKQR+AIARA+
Sbjct: 515 NIRFG-REDATMEDIVQAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQKQRVAIARAL 573
Query: 282 LRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGK 103
+RNPK+LLLD ATSALD++SE VQ AL+ + + VAHRLSTV AD I ++G
Sbjct: 574 IRNPKILLLDMATSALDNESEARVQEALNKIQHGHTIISVAHRLSTVRAADVIIGFEHGV 633
Query: 102 VAEQGTHEELLRKRSIYWRLV--QKQG 28
E+GTHEELL ++ +Y+ LV Q QG
Sbjct: 634 AVERGTHEELLERKGVYFMLVTLQSQG 660
Score = 291 bits (746), Expect = 6e-77
Identities = 192/572 (33%), Positives = 307/572 (53%), Gaps = 17/572 (2%)
Frame = -1
Query: 3594 YTLGETSQVLVKVTNAINNKTIDPV------DLAHAYKLFESDMNR-----VVLLFFLVG 3448
Y + E +LV +A N + P+ L + L + + R + L F ++G
Sbjct: 747 YNIPEWHYILVGSLSAAINGAVTPIYSLLFSQLLGTFSLLDKEQQRSEIHSMCLFFVILG 806
Query: 3447 FAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGM--STGHLSIVLNDNME 3274
FLQ G+ +R+ +L +DI +FD + + G L+ L +
Sbjct: 807 CVSIFTQFLQGYTFAKSGELLTKRLRKFGFKAMLGQDIGWFDDLRNNPGVLTTRLATDAS 866
Query: 3273 RFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLLDSWGKMKNN 3094
+ + ++ +++ T+ + ++AF+ W+L+ T+F + LSG + +
Sbjct: 867 QVQGATGSQVGMMVNSFTNIIAALLIAFFFSWKLSLIITIFFPFLALSGAVQTKMLTGFA 926
Query: 3093 EKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNRAFVFSLSRS 2914
+ + + AG I +AL +TV+ + + + ++ + EL+ K A+ +A ++ L +
Sbjct: 927 SQDKQALEKAGQITSEALSNIRTVAGIGVEGRFIKAFEVELQTSYKTAVRKANIYGLCFA 986
Query: 2913 ADYFFTNALNFVILYFGANMI-YEGTIEPGVVVRILYYILFGSYCLGEAILHISRLASAI 2737
N +G +I YEG + V R++ ++ + +G + A A
Sbjct: 987 FSQGIAFLANSAAYRYGGYLIAYEG-LGFSHVFRVVSSVVLSATAVGRTFSYTPSYAKA- 1044
Query: 2736 PLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPTRPDVPVLKEISFNVQ 2560
++ LLD + + K D FQG I F + F+YP+RPD+ VL +S +V
Sbjct: 1045 KISAARFFQLLDRKPPINVYSEAGEKWDNFQGKIDFIDCKFTYPSRPDIQVLNGLSVSVN 1104
Query: 2559 GGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAMGVVFQEPV 2380
G+ +A VG+SG GKST IQLL +Y+ D G + IDG+D +NI+ LR +G+V QEPV
Sbjct: 1105 PGQTLAFVGSSGCGKSTSIQLLERFYDPDQGTVMIDGHDSKKVNIQFLRSNIGIVSQEPV 1164
Query: 2379 LFNTSIEENIRFGK--PDATEQEIIDALKNANAFDFVCNFPDGIKTIVGERGAQLSGGQK 2206
LF+ SI +NI++G + + + I A K A DFV + P+ +T VG +G+QLS G+K
Sbjct: 1165 LFDCSIMDNIKYGDNTKEISVERAIAAAKQAQLHDFVMSLPEKYETNVGIQGSQLSRGEK 1224
Query: 2205 QRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHRLSTIRNAN 2026
QRIAIAR +VR+P+ILLLDEATSALD ESE VQ AL KA GRT IV+AHRLSTI+N++
Sbjct: 1225 QRIAIARAIVRDPKILLLDEATSALDTESEKTVQTALDKAREGRTCIVIAHRLSTIQNSD 1284
Query: 2025 KIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQT 1930
I V+ +G ++E G H++L+A G Y LV T
Sbjct: 1285 IIAVVSQGVVIEKGTHEKLMAQKGAYYKLVIT 1316
>gi|22026798|ref|NP_523740.2| CG8523-PA [Drosophila melanogaster]
gi|21645421|gb|AAF58271.2| CG8523-PA [Drosophila melanogaster]
Length = 1287
Score = 689 bits (1778), Expect = 0.0
Identities = 422/1252 (33%), Positives = 683/1252 (53%), Gaps = 26/1252 (2%)
Frame = -1
Query: 3708 LKKTFGFQI-KCTTRYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKT 3532
+K+ FQ+ + T+ ++ L+ +G++ ++ TG+ P S G + ++ + + +
Sbjct: 42 VKQVSYFQLFRYATKKDRALYVIGLLSAVATGLTTPANSLIFGNLANDMIDLGGLLESGK 101
Query: 3531 IDPVDLAHAYKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISR 3352
D A + L + + + L +G +L + + + +R ++
Sbjct: 102 SYRADDAISTLLLDK-VRQFSLQNTYIGIIMLVCSYLSITCFNYAAHSQILTIRSKFFRS 160
Query: 3351 LLRKDISYFDGMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRL 3172
+L +D+ ++D +G ++ +N+++ + + EK+ + + L FV +LAF W+L
Sbjct: 161 ILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQL 220
Query: 3171 ACYG-TVFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQE 2995
+ T + GL+ + + +K+ + A +A AL +TV + G+ +E
Sbjct: 221 SLVCLTSLPLTFIAMGLV-AVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKE 279
Query: 2994 VERYTEELKNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEP----- 2830
V Y E + + + R + +FF A + ++G ++ +G EP
Sbjct: 280 VAAYKERVVAAKILNIKRNMFSGIGFGLLWFFIYASYALAFWYGVGLVIKGYHEPAYENY 339
Query: 2829 --GVVVRILYYILFGSYCLGEAILHISRLASAIPLTVPIADILLD-SDATADEFFSEEIK 2659
G ++ + + ++ GS +G A +I A + I+ + + +++
Sbjct: 340 DAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEINPIDGEGKKLN 399
Query: 2658 DTFQGIISFKNVLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYN 2479
+ I FK V F YPTRP+V +L +++ + G+ +ALVG SG GKST IQL+ +Y+
Sbjct: 400 EPLT-TIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYD 458
Query: 2478 IDSGRISIDGNDIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALK 2299
+G + +G ++ +++I LR +GVV QEP+LF TSI ENIR+G+ DAT +EI A
Sbjct: 459 PQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGREDATREEIEAAAA 518
Query: 2298 NANAFDFVCNFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNES 2119
ANA F+ P G T+VGERGAQLSGGQKQRIAIAR L+R+P ILLLDEATSALD S
Sbjct: 519 AANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTAS 578
Query: 2118 EFIVQEALQKASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNL 1939
E VQ AL+K S GRTTI+VAHRLST+R A++I+V+ KGE+VE G H++L+ + Y NL
Sbjct: 579 EAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNL 638
Query: 1938 VQTQLMSTNYEKMNENEERVTRQSSHSDFPSNEISHQKIDQEDDYV-------KKLIAEI 1780
V TQL + ++ + + + D EI D+++D + KK ++
Sbjct: 639 VTTQLGEDDGSVLSPTGD-IYKNFDIKDEDEEEIKVLSEDEDEDVMVTDEKNKKKKKKKV 697
Query: 1779 KEEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAF-DKDEM 1603
K+ K + E++K + E+ + + + S I G P+ + L + + D D+
Sbjct: 698 KDPNEVKP-MLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGSILQILSVKDNDQY 756
Query: 1602 L-SKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDP 1426
+ S+ ++L L I F Q YFFG E+L+ +LR + F+ ++ A++DD
Sbjct: 757 VRENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDK 816
Query: 1425 CHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPL 1246
+ L RL+ D++ V A R+G+++ ++ + L + +S +Y W + L L F P
Sbjct: 817 ANGTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLVALAFTPF 876
Query: 1245 LYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNME-----NRVILLVTS 1081
+ +A Y + + + E + A+E + N+RTV +L E N + +L+ +
Sbjct: 877 ILIAFYMQRTLMAKENMGSAKTMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGMLIPA 936
Query: 1080 HLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLS 901
RN++F+ G G A S FF YA +GTW V+ IL D + V L
Sbjct: 937 VEISKRNTHFR-----GLVYGLARSLMFFAYAACMYYGTWCVIHRGILFGDVFKVSQALI 991
Query: 900 MTASYAGSAVAYLPDHRKAIHAAGLIF-HLFTYPAIMPYDSSQGKRNIKNGEIELKNVSF 724
M + +A+A+ P+ +K + AA IF L P+I+ G + V F
Sbjct: 992 MGTASIANALAFAPNMQKGVSAAKTIFTFLRRQPSIVDRPGVSRDPWHSEGYVRFDKVKF 1051
Query: 723 EYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVV 544
Y RS+ +L G+ L + G+ +ALVGPSG GKST I L++RFY +G IDE +V
Sbjct: 1052 SYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVR 1111
Query: 543 DVNLHHLRESVSLVSQEPVLFNCSIKENFLFG-ISHNASQLEIDQALKVANAFSFVSQFP 367
+V++ +LR + +VSQEP+LF+ +I+EN +G + N + EI A K +N F++ P
Sbjct: 1112 NVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARNVTDQEIISACKKSNIHEFIANLP 1171
Query: 366 QGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTAS 187
G DT +GE+GAQLSGGQKQRIAIARA++RNPK++LLDEATSALD++SEKVVQ+ALD AS
Sbjct: 1172 LGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESEKVVQDALDAAS 1231
Query: 186 ERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
E +T+ +AHRLSTVV++D I V +NG V E G H++LL R +Y+ L + Q
Sbjct: 1232 EGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLLANRGLYYTLYKLQ 1283
>gi|11038656|ref|NP_066302.1| ATP-binding cassette, sub-family B,
member 11; bile salt export pump; sister of
P-glycoprotein [Mus musculus]
gi|12643304|sp|Q9QY30|AB11_MOUSE Bile salt export pump (ATP-binding
cassette, sub-family B, member 11) (Sister of
P-glycoprotein)
gi|6502606|gb|AAF14372.1| liver bile salt export pump;
sister-of-p-glycoprotein [Mus musculus domesticus]
Length = 1321
Score = 687 bits (1773), Expect = 0.0
Identities = 429/1260 (34%), Positives = 678/1260 (53%), Gaps = 55/1260 (4%)
Frame = -1
Query: 3654 LFFLGVVFSILTGMCQPFESYTLGETSQVLVKVT----------NAINNKTIDPVDLAHA 3505
L F+G V ++L GM QP G + + V+ N TI ++ +
Sbjct: 61 LMFMGSVCALLHGMAQPGMIIVFGILTDIFVEYDIERQELSIPGKVCMNNTIVWINSSFN 120
Query: 3504 YKLFES------DMNRVVL----LFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYIS 3355
+ D+N V+ ++ VG A G+ Q + G +R+ Y
Sbjct: 121 QNMTNGTSCGLVDINSEVIKFSGIYAGVGVAVLILGYFQIRLWVITGARQIRKMRKFYFR 180
Query: 3354 RLLRKDISYFDGMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWR 3175
R++R +I +FD S G L+ +D++ + E +++AL + L+ + G +L FY W+
Sbjct: 181 RIMRMEIGWFDCTSVGELNSRFSDDINKIDEAIADQMALFLQRLSTALSGLLLGFYRGWK 240
Query: 3174 LACYGTVFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQE 2995
L S I + + K E + + + AGSIA + L +TV++ G+ +E
Sbjct: 241 LTLVILAVSPLIGIGAAVIGLSVAKFTELELKAYAKAGSIADEVLSSIRTVAAFGGENKE 300
Query: 2994 VERYTEELKNGEKYALNRAFVFSLSRSADY---FFTNALNFVILYFGANMIY-EGTIEPG 2827
VERY + L +++ + + V + FF AL F ++G+ ++ EG PG
Sbjct: 301 VERYEKNLMFAQRWGIWKGMVMGFFTGYMWCLIFFCYALAF---WYGSRLVLDEGEYTPG 357
Query: 2826 VVVRILYYILFGSYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTF 2650
+++I ++ + +G A + ++ I + D D + K D
Sbjct: 358 TLIQIFLCVIIAAMNIGNASSCLEIFSTGCSAASSIFQTI-DRQPVMDCMSGDGYKLDRI 416
Query: 2649 QGIISFKNVLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDS 2470
+G I F NV F YP+RP+V +L +S ++ GE A VG+SG+GKST +QL+ +Y+
Sbjct: 417 KGEIEFHNVTFHYPSRPEVKILNNLSMVIKPGETTAFVGSSGAGKSTALQLIQRFYDPCE 476
Query: 2469 GRISIDGNDIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNAN 2290
G +++DG+DI ++NI+ LR +G+V QEPVLF+T+I ENIR G+ +AT ++I+ A K+AN
Sbjct: 477 GMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAENIRLGREEATMEDIVQAAKDAN 536
Query: 2289 AFDFVCNFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFI 2110
A++F+ P T+VGE G Q+SGGQKQR+AIAR L+R P+ILLLD ATSALDNESE
Sbjct: 537 AYNFIMALPQQFDTLVGEGGGQMSGGQKQRVAIARALIRKPKILLLDMATSALDNESEAK 596
Query: 2109 VQEALQKASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQT 1930
VQ AL K G T I VAHRLST+R+A+ II E G VE G H++L+ GVY LV
Sbjct: 597 VQGALNKIQHGHTIISVAHRLSTVRSADVIIGFEHGTAVERGTHEELLERKGVYFMLVTL 656
Query: 1929 QLMSTNYEK----------MNENEERVTRQSSHSDF--------PSNEISHQKI------ 1822
Q N K + ER + S+ D +++SH
Sbjct: 657 QSQEDNTHKETGIKGKDTTEGDTPERTFSRGSYQDSLRASIRQRSKSQLSHLSHEPPLAI 716
Query: 1821 -DQEDDYVKKLIAEIKEEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLM 1645
D + Y + ++ E + + + I+KY SE+ + + L +AI G P+ S L
Sbjct: 717 GDHKSSYEDRKDNDVLVEEVEPAPVRRILKYNISEWPYILVGALCAAINGAVTPIYSLLF 776
Query: 1644 IKSYEAYAF-DKDEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSF 1468
+ + ++ DK++ S+ + L + L F Q Y F K+ E L+ +LR F
Sbjct: 777 SQILKTFSLVDKEQQRSEIYSMCLFFVILGCVSLFTQFLQGYNFAKSGELLTKRLRKFGF 836
Query: 1467 KHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFY 1288
K ++ ++DD + L+ RL D+S V A ++G ++ + I +AV+++F +
Sbjct: 837 KAMLRQDIGWFDDLKNNPGVLTTRLATDASQVQGATGSQVGMMVNSFTNIFVAVLIAFLF 896
Query: 1287 SWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNME 1108
+WK+SL + +F P L L+G + +D EK+ + EAL N+RTV + +E
Sbjct: 897 NWKLSLVISVFFPFLALSGAVQTKMLTGFASQDKEILEKAGQITNEALSNIRTVAGIGVE 956
Query: 1107 NRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMD 928
R I L+K + ++A + G F+ F + ++++G +L++ E++
Sbjct: 957 GRFIKAFEVELEKSYKTAIRKANVYGLCYAFSQGISFLANSAAYRYGGYLIVYEDLNFSY 1016
Query: 927 TYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFHLF-TYPAIMPYDSSQGKRNIKNG 751
+ V+ +++M+A+ G +Y P + KA +A F L P I Y + K + G
Sbjct: 1017 VFRVVSSIAMSATAVGRTFSYTPSYAKAKISAARFFQLLDRKPPIDVYSGAGEKWDNFQG 1076
Query: 750 EIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGE 571
+I+ + F Y R D +L+G+S+ + G+TLA VG SG GKST I LLERFY G
Sbjct: 1077 KIDFIDCKFTYPSRPDIQVLNGLSVSVDPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGT 1136
Query: 570 VKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQAL---KV 400
V ID + VN+ LR ++ +VSQEPVLF+CSI +N +G N ++ +++A+ K
Sbjct: 1137 VMIDGHDSKKVNVQFLRSNIGIVSQEPVLFDCSIMDNIKYG--DNTKEISVERAIAAAKQ 1194
Query: 399 ANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSE 220
A FV P+ +T VG +G+QLS G+KQRIAIARAI+R+PK+LLLDEATSALD++SE
Sbjct: 1195 AQLHDFVMSLPEKYETNVGIQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESE 1254
Query: 219 KVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLV 40
K VQ ALD A E + +V+AHRLST+ N+D IAV+ G V E+GTH++L+ ++ Y++LV
Sbjct: 1255 KTVQLALDKAREGRTCIVIAHRLSTIQNSDIIAVMSQGVVIEKGTHKKLMDQKGAYYKLV 1314
Score = 304 bits (778), Expect = 1e-80
Identities = 182/510 (35%), Positives = 281/510 (54%), Gaps = 2/510 (0%)
Frame = -1
Query: 1536 FFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVD 1357
+FQ + T + K+R F+ +M + ++D C + L++R + D + + A+
Sbjct: 157 YFQIRLWVITGARQIRKMRKFYFRRIMRMEIGWFD--CTSVGELNSRFSDDINKIDEAIA 214
Query: 1356 DRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAF 1177
D++ + L L +++ F+ WK++L +L PL+ + V + E + A+
Sbjct: 215 DQMALFLQRLSTALSGLLLGFYRGWKLTLVILAVSPLIGIGAAVIGLSVAKFTELELKAY 274
Query: 1176 EKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYF 997
K+ A E L ++RTV A EN+ + +L + + ++ G G+ F
Sbjct: 275 AKAGSIADEVLSSIRTVAAFGGENKEVERYEKNLMFAQRWGIWKGMVMGFFTGYMWCLIF 334
Query: 996 FIYAVSFKFGTWLVLRE-EILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIF 820
F YA++F +G+ LVL E E P + + + + A G+A + L AA IF
Sbjct: 335 FCYALAFWYGSRLVLDEGEYTPGTLIQIFLCVIIAAMNIGNASSCLEIFSTGCSAASSIF 394
Query: 819 HLFTYPAIMPYDSSQG-KRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALV 643
+M S G K + GEIE NV+F Y R + IL+ +S+ + G T A V
Sbjct: 395 QTIDRQPVMDCMSGDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNNLSMVIKPGETTAFV 454
Query: 642 GPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKE 463
G SG+GKST + L++RFY +G V +D ++ +N+ LR+ + +V QEPVLF+ +I E
Sbjct: 455 GSSGAGKSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAE 514
Query: 462 NFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAI 283
N G A+ +I QA K ANA++F+ PQ DTLVGE G Q+SGGQKQR+AIARA+
Sbjct: 515 NIRLG-REEATMEDIVQAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQKQRVAIARAL 573
Query: 282 LRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGK 103
+R PK+LLLD ATSALD++SE VQ AL+ + + VAHRLSTV +AD I ++G
Sbjct: 574 IRKPKILLLDMATSALDNESEAKVQGALNKIQHGHTIISVAHRLSTVRSADVIIGFEHGT 633
Query: 102 VAEQGTHEELLRKRSIYWRLVQKQGIQVET 13
E+GTHEELL ++ +Y+ LV Q + T
Sbjct: 634 AVERGTHEELLERKGVYFMLVTLQSQEDNT 663
Score = 295 bits (756), Expect = 4e-78
Identities = 193/571 (33%), Positives = 302/571 (52%), Gaps = 16/571 (2%)
Frame = -1
Query: 3594 YTLGETSQVLVKVTNAINNKTIDPV------DLAHAYKLFESDMNR-----VVLLFFLVG 3448
Y + E +LV A N + P+ + + L + + R + L F ++G
Sbjct: 747 YNISEWPYILVGALCAAINGAVTPIYSLLFSQILKTFSLVDKEQQRSEIYSMCLFFVILG 806
Query: 3447 FAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMST--GHLSIVLNDNME 3274
FLQ G+ +R+ +LR+DI +FD + G L+ L +
Sbjct: 807 CVSLFTQFLQGYNFAKSGELLTKRLRKFGFKAMLRQDIGWFDDLKNNPGVLTTRLATDAS 866
Query: 3273 RFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLLDSWGKMKNN 3094
+ + ++ +++ T+ + ++AF +W+L+ +VF + LSG + +
Sbjct: 867 QVQGATGSQVGMMVNSFTNIFVAVLIAFLFNWKLSLVISVFFPFLALSGAVQTKMLTGFA 926
Query: 3093 EKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNRAFVFSLSRS 2914
+ E + AG I +AL +TV+ + + + ++ + EL+ K A+ +A V+ L +
Sbjct: 927 SQDKEILEKAGQITNEALSNIRTVAGIGVEGRFIKAFEVELEKSYKTAIRKANVYGLCYA 986
Query: 2913 ADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEAILHISRLASAIP 2734
+ N +G +I + V R++ I + +G + A A
Sbjct: 987 FSQGISFLANSAAYRYGGYLIVYEDLNFSYVFRVVSSIAMSATAVGRTFSYTPSYAKA-K 1045
Query: 2733 LTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPTRPDVPVLKEISFNVQG 2557
++ LLD D + K D FQG I F + F+YP+RPD+ VL +S +V
Sbjct: 1046 ISAARFFQLLDRKPPIDVYSGAGEKWDNFQGKIDFIDCKFTYPSRPDIQVLNGLSVSVDP 1105
Query: 2556 GECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAMGVVFQEPVL 2377
G+ +A VG+SG GKST IQLL +Y+ D G + IDG+D +N++ LR +G+V QEPVL
Sbjct: 1106 GQTLAFVGSSGCGKSTSIQLLERFYDPDQGTVMIDGHDSKKVNVQFLRSNIGIVSQEPVL 1165
Query: 2376 FNTSIEENIRFGK--PDATEQEIIDALKNANAFDFVCNFPDGIKTIVGERGAQLSGGQKQ 2203
F+ SI +NI++G + + + I A K A DFV + P+ +T VG +G+QLS G+KQ
Sbjct: 1166 FDCSIMDNIKYGDNTKEISVERAIAAAKQAQLHDFVMSLPEKYETNVGIQGSQLSRGEKQ 1225
Query: 2202 RIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHRLSTIRNANK 2023
RIAIAR +VR+P+ILLLDEATSALD ESE VQ AL KA GRT IV+AHRLSTI+N++
Sbjct: 1226 RIAIARAIVRDPKILLLDEATSALDTESEKTVQLALDKAREGRTCIVIAHRLSTIQNSDI 1285
Query: 2022 IIVMEKGEIVEVGDHKQLIAMNGVYNNLVQT 1930
I VM +G ++E G HK+L+ G Y LV T
Sbjct: 1286 IAVMSQGVVIEKGTHKKLMDQKGAYYKLVIT 1316
>gi|12643301|sp|O95342|AB11_HUMAN Bile salt export pump (ATP-binding
cassette, sub-family B, member 11)
gi|3873243|gb|AAC77455.1| bile salt export pump [Homo sapiens]
Length = 1321
Score = 686 bits (1770), Expect = 0.0
Identities = 416/1186 (35%), Positives = 648/1186 (54%), Gaps = 35/1186 (2%)
Frame = -1
Query: 3492 ESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMS 3313
ES+M + + + A G++Q +R+ Y R++R +I +FD S
Sbjct: 135 ESEMIKFASYYAGIAVAVLITGYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDCNS 194
Query: 3312 TGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVL 3133
G L+ +D++ + + +++AL I +T + G +L F+ W+L S I +
Sbjct: 195 VGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIGI 254
Query: 3132 SGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKY 2953
K + + + + AG +A + + +TV++ G+++EVERY + L +++
Sbjct: 255 GAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRW 314
Query: 2952 ALNRAFVFSLSRSADYFFTNALNFVILYFGANMIY-EGTIEPGVVVRILYYILFGSYCLG 2776
+ + V + V ++G+ ++ EG PG +V+I ++ G+ LG
Sbjct: 315 GIRKGIVMGFFTGFVWCLIFLCYAVAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNLG 374
Query: 2775 EAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPTRP 2599
A + A+ I + + D D + K D +G I F NV F YP+RP
Sbjct: 375 NASPCLEAFATGRAAATSIFETI-DRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRP 433
Query: 2598 DVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQ 2419
+V +L +++ ++ GE ALVG SG+GKST +QL+ +Y+ G +++DG+DI ++NI+
Sbjct: 434 EVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQW 493
Query: 2418 LRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVG 2239
LR +G+V QEPVLF+T+I ENIR+G+ DAT ++I+ A K ANA++F+ + P T+VG
Sbjct: 494 LRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVG 553
Query: 2238 ERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVV 2059
E G Q+SGGQKQR+AIAR L+RNP+ILLLD ATSALDNESE +VQE L K G T I V
Sbjct: 554 EGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISV 613
Query: 2058 AHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNENEERV 1879
AHRLST+R A+ II E G VE G H++L+ GVY LV Q S + +NE + +
Sbjct: 614 AHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQ--SQGNQALNEEDIKD 671
Query: 1878 T-----------------------RQSSHSDF-------PSNEISHQKIDQEDDYVKKLI 1789
RQ S S P + H+ +ED K +
Sbjct: 672 ATEDDMLARTFSRGSYQDSLRASIRQRSKSQLSYLVHEPPLAVVDHKSTYEEDRKDKDIP 731
Query: 1788 AEIKEEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAF-DK 1612
+ + E A + I+K+ E+ + + +G+A+ G PL + L + ++ DK
Sbjct: 732 VQEEVEPAP---VRRILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQILGTFSIPDK 788
Query: 1611 DEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYD 1432
+E S+ + L + + F Q Y F K+ E L+ +LR F+ ++ A++D
Sbjct: 789 EEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFD 848
Query: 1431 DPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFC 1252
D ++ L+ RL D+S V A ++G ++ + + +A+I++F +SWK+SL +L F
Sbjct: 849 DLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFF 908
Query: 1251 PLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQ 1072
P L L+G + D A E + EAL N+RTV + E R I + + L+
Sbjct: 909 PFLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELE 968
Query: 1071 KIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTA 892
K + ++A I G FA F + S+++G +L+ E + + V+ + ++A
Sbjct: 969 KPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSA 1028
Query: 891 SYAGSAVAYLPDHRKAIHAAGLIFHLFT-YPAIMPYDSSQGKRNIKNGEIELKNVSFEYA 715
+ G A +Y P + KA +A F L P I Y+++ K + G+I+ + F Y
Sbjct: 1029 TALGRAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYP 1088
Query: 714 QRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVN 535
R D +L+G+S+ + G+TLA VG SG GKST I LLERFY G+V ID + VN
Sbjct: 1089 SRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVN 1148
Query: 534 LHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLE-IDQALKVANAFSFVSQFPQGL 358
+ LR ++ +VSQEPVLF CSI +N +G + +E + A K A FV P+
Sbjct: 1149 VQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKY 1208
Query: 357 DTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERL 178
+T VG +G+QLS G+KQRIAIARAI+R+PK+LLLDEATSALD++SEK VQ ALD A E
Sbjct: 1209 ETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGR 1268
Query: 177 STVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLV 40
+ +V+AHRLST+ NAD IAV+ G V E+GTHEEL+ ++ Y++LV
Sbjct: 1269 TCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLV 1314
Score = 306 bits (784), Expect = 3e-81
Identities = 182/509 (35%), Positives = 284/509 (55%), Gaps = 4/509 (0%)
Frame = -1
Query: 1536 FFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVD 1357
+ Q F+ A + K+R F+ +M + ++D C++ L+ R + D + + A+
Sbjct: 157 YIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFD--CNSVGELNTRFSDDINKINDAIA 214
Query: 1356 DRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAF 1177
D++ I + + + ++ FF WK++L ++ PL+ + V + + + A+
Sbjct: 215 DQMALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAY 274
Query: 1176 EKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYF 997
K+ A E + ++RTV A E R + +L + ++ ++ G GF F
Sbjct: 275 AKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIF 334
Query: 996 FIYAVSFKFGTWLVLRE-EILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIF 820
YAV+F +G+ LVL E E P + +++ + A G+A L AA IF
Sbjct: 335 LCYAVAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIF 394
Query: 819 HLFTYPAIMPYDSSQG-KRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALV 643
I+ S G K + GEIE NV+F Y R + IL+ +++ + G ALV
Sbjct: 395 ETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALV 454
Query: 642 GPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKE 463
GPSG+GKST + L++RFY +G V +D ++ +N+ LR+ + +V QEPVLF+ +I E
Sbjct: 455 GPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAE 514
Query: 462 NFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAI 283
N +G +A+ +I QA K ANA++F+ PQ DTLVGE G Q+SGGQKQR+AIARA+
Sbjct: 515 NIRYG-REDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARAL 573
Query: 282 LRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGK 103
+RNPK+LLLD ATSALD++SE +VQ L + + VAHRLSTV AD+I ++G
Sbjct: 574 IRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGT 633
Query: 102 VAEQGTHEELLRKRSIYWRLV--QKQGIQ 22
E+GTHEELL ++ +Y+ LV Q QG Q
Sbjct: 634 AVERGTHEELLERKGVYFTLVTLQSQGNQ 662
Score = 291 bits (746), Expect = 6e-77
Identities = 185/524 (35%), Positives = 281/524 (53%), Gaps = 4/524 (0%)
Frame = -1
Query: 3489 SDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGM-- 3316
S +N V LLF +G FLQ G+ +R+ +L +DI++FD +
Sbjct: 793 SQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRN 852
Query: 3315 STGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIV 3136
S G L+ L + + + +I +I+ T+ + I+AF W+L+ F +
Sbjct: 853 SPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLA 912
Query: 3135 LSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEK 2956
LSG + + + + G I +AL +TV+ + +++ +E EL+ K
Sbjct: 913 LSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELEKPFK 972
Query: 2955 YALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLG 2776
A+ +A ++ + N +G +I + V R++ ++ + LG
Sbjct: 973 TAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALG 1032
Query: 2775 EAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIKDTFQGIISFKNVLFSYPTRPD 2596
A + A A +L + + E D FQG I F + F+YP+RPD
Sbjct: 1033 RAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPD 1092
Query: 2595 VPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQL 2416
VL +S ++ G+ +A VG+SG GKST IQLL +Y+ D G++ IDG+D +N++ L
Sbjct: 1093 SQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFL 1152
Query: 2415 RQAMGVVFQEPVLFNTSIEENIRFGK--PDATEQEIIDALKNANAFDFVCNFPDGIKTIV 2242
R +G+V QEPVLF SI +NI++G + + +I A K A DFV + P+ +T V
Sbjct: 1153 RSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNV 1212
Query: 2241 GERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIV 2062
G +G+QLS G+KQRIAIAR +VR+P+ILLLDEATSALD ESE VQ AL KA GRT IV
Sbjct: 1213 GSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIV 1272
Query: 2061 VAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQT 1930
+AHRLSTI+NA+ I VM +G ++E G H++L+A G Y LV T
Sbjct: 1273 IAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLVTT 1316
>gi|40644167|emb|CAC86593.1| sister of P-glycoprotein [Platichthys
flesus]
gi|40644169|emb|CAC86594.1| sister of P-glycoprotein [Platichthys
flesus]
Length = 1356
Score = 686 bits (1770), Expect = 0.0
Identities = 429/1230 (34%), Positives = 660/1230 (52%), Gaps = 45/1230 (3%)
Frame = -1
Query: 3594 YTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFESDMNRVVLLFFLVGFAYFTFGFLQF 3415
++L T +VLV + N T +D+ E +M + L + + FA F G+LQ
Sbjct: 137 WSLNSTWEVLVP----LKNLTCGVLDI-------EYEMTKFALYYVGIAFAVFLLGYLQI 185
Query: 3414 SIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMSTGHLSIVLNDNMERFREVFNEKIALI 3235
S+ VR+ Y S+++R +I +FD S G L+ ++D++ + + +++A+
Sbjct: 186 SLWVQAAARQVQIVRKMYFSKVMRMEIGWFDCTSVGELNTRMSDDINKINDAIADQVAIF 245
Query: 3234 IALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSI 3055
+ T FV G + F W+L S I + + K ++ + + AG++
Sbjct: 246 LQRFTTFVCGFCIGFVKGWKLTLVIVAASPLIGIGAGFMALFVAKLTGRELQAYAKAGAV 305
Query: 3054 AFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNRAFVFSLSRSADYFFTNALNFVI 2875
A + L +TVS+ G+ +EV+RY L + +++ + + + + +
Sbjct: 306 ADEVLSSIRTVSAFGGELKEVQRYDRNLISAQRWGIRKGMIMGFFTGYMWLIIFLCYALA 365
Query: 2874 LYFGANMIYE-GTIEPGVVVRILYYILFGSYCLGEAILHISRLASAIPLTVPIADILLDS 2698
++G+ ++ + PG ++++ + +L + LG+A + A+ I + + D
Sbjct: 366 FWYGSGLVLDTAEYTPGTLLQVFFGVLIAAMNLGQASPCLEAFAAGRGAATIIFETI-DR 424
Query: 2697 DATADEFFSEEIK-DTFQGIISFKNVLFSYPTRPDVPVLKEISFNVQGGECIALVGASGS 2521
+ D K D +G I F NV F YP+RP+V L ++S V+ GE A VG SG+
Sbjct: 425 EPEIDCLSEAGYKLDRVKGDIEFHNVTFHYPSRPEVKTLDQLSVAVKSGETTAFVGPSGA 484
Query: 2520 GKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFG 2341
GKST IQL +Y+ G +++DG+DI +NI+ LR +G+V QEPVLF T+I ENI +G
Sbjct: 485 GKSTAIQLFQRFYDPKEGMVTLDGHDIRGLNIQWLRSLIGIVEQEPVLFATTIAENICYG 544
Query: 2340 KPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRI 2161
+P + ++I+ A K ANA+ F+ + P T+VGE G Q+SGGQKQRIAIAR LVRNPRI
Sbjct: 545 RPGVSMEDIVAAAKEANAYHFIQDLPQKFNTMVGEGGGQMSGGQKQRIAIARALVRNPRI 604
Query: 2160 LLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGD 1981
LLLD ATSALDNESE IVQEAL K +GRTTI +AHRLSTI+NA+ I+ E G VE G
Sbjct: 605 LLLDMATSALDNESEAIVQEALDKVRLGRTTISIAHRLSTIKNADVIVGFEHGRAVEKGK 664
Query: 1980 HKQLIAMNGVYNNLVQTQ-------------LMSTNYEKMNENEERV----------TRQ 1870
H +L+ GVY LV Q L E + +N R RQ
Sbjct: 665 HGELLERKGVYFMLVTLQSQGDKALNEKARQLAEKEEEPVKQNLSRAGSYRASLRSSIRQ 724
Query: 1869 SSHSDFPSNEISHQK-------------IDQEDDYVKKLIAEIKEEGAKKSNICEIIKYC 1729
S S SN I Q D + E +EE + + + I+KY
Sbjct: 725 RSRSQL-SNLIPDSSASMVGELGPRTYTFSQPDTSKADIPEEEEEEVVEPAPVARILKYN 783
Query: 1728 RSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAF-----DKDEMLSKSHFWALSILF 1564
E+ + +G+AI G P+ S L + ++ + E+ S F+ + +
Sbjct: 784 IPEWPYMLFGSIGAAINGGVNPVYSLLFSQILATFSVTDPVAQRKEIDSICMFFVMVGVV 843
Query: 1563 LAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNAD 1384
+FT+ + Q Y F K+ E L+ +LR + F ++ ++DD ++ L+ RL D
Sbjct: 844 SSFTQML----QGYAFSKSGELLTRRLRRLGFHAMLGQEIGWFDDHRNSPGALTTRLATD 899
Query: 1383 SSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQ 1204
+S V A ++G ++ +L I +AV+MSF++SWK+++ +L F P + L+G +
Sbjct: 900 ASQVQGATGSQIGMIVNSLTNIGVAVLMSFYFSWKLTMLILCFLPFIALSGGFQAKMLTG 959
Query: 1203 AVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTA 1024
++D A E + R + EAL N+RT+ L E + + + L + K+A + G
Sbjct: 960 FAKQDKEAMEAAGRISGEALNNIRTIAGLGKEQSFVDMYEAQLDGPFQAALKKAHVYGAC 1019
Query: 1023 NGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKA 844
GFA F + S++FG +LV +E + + V+ + + + G A +Y PD+ KA
Sbjct: 1020 YGFAQCVVFLTNSASYRFGGYLVRQEGLHFSLVFRVISAIVTSGTALGKASSYTPDYAKA 1079
Query: 843 IHAAGLIFHLFT-YPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLP 667
+A F L P I Y K + G +E + F Y R D +L+G+++ +
Sbjct: 1080 KISAARFFKLLDRVPQISVYSDKGDKWDNFQGNLEFIDCKFTYPTRPDIQVLNGLNVSVR 1139
Query: 666 AGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPV 487
G+TLA VG SG GKST + LLERFY G V ID + VN+ LR + +VSQEP+
Sbjct: 1140 PGQTLAFVGSSGCGKSTSVQLLERFYDPDHGRVLIDGHDSTGVNVPFLRSKIGIVSQEPI 1199
Query: 486 LFNCSIKENFLFGI-SHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQK 310
LF+CSI +N +G S S ++ A K A +FV P+ DT VG +G+QLS GQK
Sbjct: 1200 LFDCSIADNIKYGDNSREISLNDVMSAAKKAQLHNFVMALPEKYDTNVGAQGSQLSRGQK 1259
Query: 309 QRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNAD 130
QRIAIARAI+R+PK+LLLDEATSALD++SEK+VQ ALD A E + +V+AHRLST+ N+D
Sbjct: 1260 QRIAIARAIIRDPKILLLDEATSALDTESEKIVQEALDKAREGRTCIVIAHRLSTIQNSD 1319
Query: 129 SIAVLKNGKVAEQGTHEELLRKRSIYWRLV 40
IAV+ G V E+GTH +L+ + Y++LV
Sbjct: 1320 IIAVMSRGYVIEKGTHNQLMLLKGAYYKLV 1349
Score = 295 bits (756), Expect = 4e-78
Identities = 188/527 (35%), Positives = 292/527 (54%), Gaps = 8/527 (1%)
Frame = -1
Query: 3486 DMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGM--S 3313
+++ + + F +VG LQ G+ +RR +L ++I +FD S
Sbjct: 829 EIDSICMFFVMVGVVSSFTQMLQGYAFSKSGELLTRRLRRLGFHAMLGQEIGWFDDHRNS 888
Query: 3312 TGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVL 3133
G L+ L + + + +I +I+ LT+ + +++FY W+L F I L
Sbjct: 889 PGALTTRLATDASQVQGATGSQIGMIVNSLTNIGVAVLMSFYFSWKLTMLILCFLPFIAL 948
Query: 3132 SGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKY 2953
SG + ++ E + AG I+ +AL +T++ L +Q V+ Y +L +
Sbjct: 949 SGGFQAKMLTGFAKQDKEAMEAAGRISGEALNNIRTIAGLGKEQSFVDMYEAQLDGPFQA 1008
Query: 2952 ALNRAFVFSLS---RSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYC 2782
AL +A V+ F TN+ ++ FG ++ + + +V R++ I+
Sbjct: 1009 ALKKAHVYGACYGFAQCVVFLTNSASY---RFGGYLVRQEGLHFSLVFRVISAIVTSGTA 1065
Query: 2781 LGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPT 2605
LG+A + A A ++ LLD + + K D FQG + F + F+YPT
Sbjct: 1066 LGKASSYTPDYAKA-KISAARFFKLLDRVPQISVYSDKGDKWDNFQGNLEFIDCKFTYPT 1124
Query: 2604 RPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINI 2425
RPD+ VL ++ +V+ G+ +A VG+SG GKST +QLL +Y+ D GR+ IDG+D +N+
Sbjct: 1125 RPDIQVLNGLNVSVRPGQTLAFVGSSGCGKSTSVQLLERFYDPDHGRVLIDGHDSTGVNV 1184
Query: 2424 KQLRQAMGVVFQEPVLFNTSIEENIRFG--KPDATEQEIIDALKNANAFDFVCNFPDGIK 2251
LR +G+V QEP+LF+ SI +NI++G + + +++ A K A +FV P+
Sbjct: 1185 PFLRSKIGIVSQEPILFDCSIADNIKYGDNSREISLNDVMSAAKKAQLHNFVMALPEKYD 1244
Query: 2250 TIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRT 2071
T VG +G+QLS GQKQRIAIAR ++R+P+ILLLDEATSALD ESE IVQEAL KA GRT
Sbjct: 1245 TNVGAQGSQLSRGQKQRIAIARAIIRDPKILLLDEATSALDTESEKIVQEALDKAREGRT 1304
Query: 2070 TIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQT 1930
IV+AHRLSTI+N++ I VM +G ++E G H QL+ + G Y LV T
Sbjct: 1305 CIVIAHRLSTIQNSDIIAVMSRGYVIEKGTHNQLMLLKGAYYKLVTT 1351
Score = 285 bits (728), Expect = 8e-75
Identities = 179/523 (34%), Positives = 277/523 (52%), Gaps = 4/523 (0%)
Frame = -1
Query: 1584 WALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRL 1405
+AL + +AF + + Q + + A + +R M F +M + ++D C + L
Sbjct: 166 FALYYVGIAFAVFLLGYLQISLWVQAAARQVQIVRKMYFSKVMRMEIGWFD--CTSVGEL 223
Query: 1404 SNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYC 1225
+ R++ D + + A+ D++ + + + F WK++L ++ PL+ +
Sbjct: 224 NTRMSDDINKINDAIADQVAIFLQRFTTFVCGFCIGFVKGWKLTLVIVAASPLIGIGAGF 283
Query: 1224 NDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKR 1045
FV + + A+ K+ A E L ++RTV A E + + +L + ++
Sbjct: 284 MALFVAKLTGRELQAYAKAGAVADEVLSSIRTVSAFGGELKEVQRYDRNLISAQRWGIRK 343
Query: 1044 AVIQGTANGFACSCYFFIYAVSFKFGTWLVL-REEILPMDTYLVLMTLSMTASYAGSAVA 868
+I G G+ F YA++F +G+ LVL E P V + + A G A
Sbjct: 344 GMIMGFFTGYMWLIIFLCYALAFWYGSGLVLDTAEYTPGTLLQVFFGVLIAAMNLGQASP 403
Query: 867 YLPDHRKAIHAAGLIFHLFTY-PAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMIL 691
L AA +IF P I + K + G+IE NV+F Y R + L
Sbjct: 404 CLEAFAAGRGAATIIFETIDREPEIDCLSEAGYKLDRVKGDIEFHNVTFHYPSRPEVKTL 463
Query: 690 DGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESV 511
D +S+ + +G T A VGPSG+GKST I L +RFY +G V +D ++ +N+ LR +
Sbjct: 464 DQLSVAVKSGETTAFVGPSGAGKSTAIQLFQRFYDPKEGMVTLDGHDIRGLNIQWLRSLI 523
Query: 510 SLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGA 331
+V QEPVLF +I EN +G S +I A K ANA+ F+ PQ +T+VGE G
Sbjct: 524 GIVEQEPVLFATTIAENICYG-RPGVSMEDIVAAAKEANAYHFIQDLPQKFNTMVGEGGG 582
Query: 330 QLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRL 151
Q+SGGQKQRIAIARA++RNP++LLLD ATSALD++SE +VQ ALD +T+ +AHRL
Sbjct: 583 QMSGGQKQRIAIARALVRNPRILLLDMATSALDNESEAIVQEALDKVRLGRTTISIAHRL 642
Query: 150 STVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLV--QKQG 28
ST+ NAD I ++G+ E+G H ELL ++ +Y+ LV Q QG
Sbjct: 643 STIKNADVIVGFEHGRAVEKGKHGELLERKGVYFMLVTLQSQG 685
>gi|4704820|gb|AAD28285.1| bile salt export pump [Homo sapiens]
Length = 1321
Score = 685 bits (1768), Expect = 0.0
Identities = 415/1186 (34%), Positives = 648/1186 (53%), Gaps = 35/1186 (2%)
Frame = -1
Query: 3492 ESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMS 3313
ES+M + + + A G++Q +R+ Y R++R +I +FD S
Sbjct: 135 ESEMIKFASYYAGIAVAVLITGYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDCNS 194
Query: 3312 TGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVL 3133
G L+ +D++ + + +++AL I +T + G +L F+ W+L S I +
Sbjct: 195 VGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIGI 254
Query: 3132 SGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKY 2953
K + + + + AG +A + + +TV++ G+++EVERY + L +++
Sbjct: 255 GAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRW 314
Query: 2952 ALNRAFVFSLSRSADYFFTNALNFVILYFGANMIY-EGTIEPGVVVRILYYILFGSYCLG 2776
+ + V + + ++G+ ++ EG PG +V+I ++ G+ LG
Sbjct: 315 GIRKGIVMGFFTGFVWCLIFLCYALAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNLG 374
Query: 2775 EAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPTRP 2599
A + A+ I + + D D + K D +G I F NV F YP+RP
Sbjct: 375 NASPCLEAFATGRAAATSIFETI-DRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRP 433
Query: 2598 DVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQ 2419
+V +L +++ ++ GE ALVG SG+GKST +QL+ +Y+ G +++DG+DI ++NI+
Sbjct: 434 EVKILNDLNMAIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQW 493
Query: 2418 LRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVG 2239
LR +G+V QEPVLF+T+I ENIR+G+ DAT ++I+ A K ANA++F+ + P T+VG
Sbjct: 494 LRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVG 553
Query: 2238 ERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVV 2059
E G Q+SGGQKQR+AIAR L+RNP+ILLLD ATSALDNESE +VQE L K G T I V
Sbjct: 554 EGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISV 613
Query: 2058 AHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNENEERV 1879
AHRLST+R A+ II E G VE G H++L+ GVY LV Q S + +NE + +
Sbjct: 614 AHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQ--SQGNQALNEEDIKD 671
Query: 1878 T-----------------------RQSSHSDF-------PSNEISHQKIDQEDDYVKKLI 1789
RQ S S P + H+ +ED K +
Sbjct: 672 ATEDDMLARTFSRGSYQDSLRASIRQRSKSQLSYLVHEPPLAVVDHKSTYEEDRKDKDIP 731
Query: 1788 AEIKEEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAF-DK 1612
+ + E A + I+K+ E+ + + +G+A+ G PL + L + ++ DK
Sbjct: 732 VQEEVEPAP---VRRILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQILGTFSIPDK 788
Query: 1611 DEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYD 1432
+E S+ + L + + F Q Y F K+ E L+ +LR F+ ++ A++D
Sbjct: 789 EEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFD 848
Query: 1431 DPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFC 1252
D ++ L+ RL D+S V A ++G ++ + + +A+I++F +SWK+SL +L F
Sbjct: 849 DLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFF 908
Query: 1251 PLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQ 1072
P L L+G + D A E + EAL N+RTV + E R I + + L+
Sbjct: 909 PFLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELE 968
Query: 1071 KIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTA 892
K + ++A I G FA F + S+++G +L+ E + + V+ + ++A
Sbjct: 969 KPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSA 1028
Query: 891 SYAGSAVAYLPDHRKAIHAAGLIFHLFT-YPAIMPYDSSQGKRNIKNGEIELKNVSFEYA 715
+ G A +Y P + KA +A F L P I Y+++ K + G+I+ + F Y
Sbjct: 1029 TALGRAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYP 1088
Query: 714 QRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVN 535
R D +L+G+S+ + G+TLA VG SG GKST I LLERFY G+V ID + VN
Sbjct: 1089 SRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVN 1148
Query: 534 LHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLE-IDQALKVANAFSFVSQFPQGL 358
+ LR ++ +VSQEPVLF CSI +N +G + +E + A K A FV P+
Sbjct: 1149 VQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKY 1208
Query: 357 DTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERL 178
+T VG +G+QLS G+KQRIAIARAI+R+PK+LLLDEATSALD++SEK VQ ALD A E
Sbjct: 1209 ETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGR 1268
Query: 177 STVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLV 40
+ +V+AHRLST+ NAD IAV+ G V E+GTHEEL+ ++ Y++LV
Sbjct: 1269 TCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLV 1314
Score = 305 bits (782), Expect = 4e-81
Identities = 181/509 (35%), Positives = 284/509 (55%), Gaps = 4/509 (0%)
Frame = -1
Query: 1536 FFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVD 1357
+ Q F+ A + K+R F+ +M + ++D C++ L+ R + D + + A+
Sbjct: 157 YIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFD--CNSVGELNTRFSDDINKINDAIA 214
Query: 1356 DRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAF 1177
D++ I + + + ++ FF WK++L ++ PL+ + V + + + A+
Sbjct: 215 DQMALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAY 274
Query: 1176 EKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYF 997
K+ A E + ++RTV A E R + +L + ++ ++ G GF F
Sbjct: 275 AKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIF 334
Query: 996 FIYAVSFKFGTWLVLRE-EILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIF 820
YA++F +G+ LVL E E P + +++ + A G+A L AA IF
Sbjct: 335 LCYALAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIF 394
Query: 819 HLFTYPAIMPYDSSQG-KRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALV 643
I+ S G K + GEIE NV+F Y R + IL+ +++ + G ALV
Sbjct: 395 ETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMAIKPGEMTALV 454
Query: 642 GPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKE 463
GPSG+GKST + L++RFY +G V +D ++ +N+ LR+ + +V QEPVLF+ +I E
Sbjct: 455 GPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAE 514
Query: 462 NFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAI 283
N +G +A+ +I QA K ANA++F+ PQ DTLVGE G Q+SGGQKQR+AIARA+
Sbjct: 515 NIRYG-REDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARAL 573
Query: 282 LRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGK 103
+RNPK+LLLD ATSALD++SE +VQ L + + VAHRLSTV AD+I ++G
Sbjct: 574 IRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGT 633
Query: 102 VAEQGTHEELLRKRSIYWRLV--QKQGIQ 22
E+GTHEELL ++ +Y+ LV Q QG Q
Sbjct: 634 AVERGTHEELLERKGVYFTLVTLQSQGNQ 662
Score = 291 bits (746), Expect = 6e-77
Identities = 185/524 (35%), Positives = 281/524 (53%), Gaps = 4/524 (0%)
Frame = -1
Query: 3489 SDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGM-- 3316
S +N V LLF +G FLQ G+ +R+ +L +DI++FD +
Sbjct: 793 SQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRN 852
Query: 3315 STGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIV 3136
S G L+ L + + + +I +I+ T+ + I+AF W+L+ F +
Sbjct: 853 SPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLA 912
Query: 3135 LSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEK 2956
LSG + + + + G I +AL +TV+ + +++ +E EL+ K
Sbjct: 913 LSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELEKPFK 972
Query: 2955 YALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLG 2776
A+ +A ++ + N +G +I + V R++ ++ + LG
Sbjct: 973 TAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALG 1032
Query: 2775 EAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIKDTFQGIISFKNVLFSYPTRPD 2596
A + A A +L + + E D FQG I F + F+YP+RPD
Sbjct: 1033 RAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPD 1092
Query: 2595 VPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQL 2416
VL +S ++ G+ +A VG+SG GKST IQLL +Y+ D G++ IDG+D +N++ L
Sbjct: 1093 SQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFL 1152
Query: 2415 RQAMGVVFQEPVLFNTSIEENIRFGK--PDATEQEIIDALKNANAFDFVCNFPDGIKTIV 2242
R +G+V QEPVLF SI +NI++G + + +I A K A DFV + P+ +T V
Sbjct: 1153 RSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNV 1212
Query: 2241 GERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIV 2062
G +G+QLS G+KQRIAIAR +VR+P+ILLLDEATSALD ESE VQ AL KA GRT IV
Sbjct: 1213 GSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIV 1272
Query: 2061 VAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQT 1930
+AHRLSTI+NA+ I VM +G ++E G H++L+A G Y LV T
Sbjct: 1273 IAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLVTT 1316
>gi|21536378|ref|NP_003733.2| ATP-binding cassette, sub-family B
(MDR/TAP), member 11; ABC member 16, MDR/TAP subfamily;
progressive familial intrahepatic cholestasis 2; bile
salt export pump [Homo sapiens]
Length = 1321
Score = 685 bits (1767), Expect = 0.0
Identities = 415/1186 (34%), Positives = 648/1186 (53%), Gaps = 35/1186 (2%)
Frame = -1
Query: 3492 ESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMS 3313
ES+M + + + A G++Q +R+ Y R++R +I +FD S
Sbjct: 135 ESEMIKFASYYAGIAVAVLITGYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDCNS 194
Query: 3312 TGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVL 3133
G L+ +D++ + + +++AL I +T + G +L F+ W+L S I +
Sbjct: 195 VGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIGI 254
Query: 3132 SGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKY 2953
K + + + + AG +A + + +TV++ G+++EVERY + L +++
Sbjct: 255 GAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRW 314
Query: 2952 ALNRAFVFSLSRSADYFFTNALNFVILYFGANMIY-EGTIEPGVVVRILYYILFGSYCLG 2776
+ + V + + ++G+ ++ EG PG +V+I ++ G+ LG
Sbjct: 315 GIRKGIVMGFFTGFVWCLIFLCYALAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNLG 374
Query: 2775 EAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPTRP 2599
A + A+ I + + D D + K D +G I F NV F YP+RP
Sbjct: 375 NASPCLEAFATGRAAATSIFETI-DRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRP 433
Query: 2598 DVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQ 2419
+V +L +++ ++ GE ALVG SG+GKST +QL+ +Y+ G +++DG+DI ++NI+
Sbjct: 434 EVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQW 493
Query: 2418 LRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVG 2239
LR +G+V QEPVLF+T+I ENIR+G+ DAT ++I+ A K ANA++F+ + P T+VG
Sbjct: 494 LRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVG 553
Query: 2238 ERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVV 2059
E G Q+SGGQKQR+AIAR L+RNP+ILLLD ATSALDNESE +VQE L K G T I V
Sbjct: 554 EGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISV 613
Query: 2058 AHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNENEERV 1879
AHRLST+R A+ II E G VE G H++L+ GVY LV Q S + +NE + +
Sbjct: 614 AHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQ--SQGNQALNEEDIKD 671
Query: 1878 T-----------------------RQSSHSDF-------PSNEISHQKIDQEDDYVKKLI 1789
RQ S S P + H+ +ED K +
Sbjct: 672 ATEDDMLARTFSRGSYQDSLRASIRQRSKSQLSYLVHEPPLAVVDHKSTYEEDRKDKDIP 731
Query: 1788 AEIKEEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAF-DK 1612
+ + E A + I+K+ E+ + + +G+A+ G PL + L + ++ DK
Sbjct: 732 VQEEVEPAP---VRRILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQILGTFSIPDK 788
Query: 1611 DEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYD 1432
+E S+ + L + + F Q Y F K+ E L+ +LR F+ ++ A++D
Sbjct: 789 EEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFD 848
Query: 1431 DPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFC 1252
D ++ L+ RL D+S V A ++G ++ + + +A+I++F +SWK+SL +L F
Sbjct: 849 DLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFF 908
Query: 1251 PLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQ 1072
P L L+G + D A E + EAL N+RTV + E R I + + L+
Sbjct: 909 PFLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELE 968
Query: 1071 KIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTA 892
K + ++A I G FA F + S+++G +L+ E + + V+ + ++A
Sbjct: 969 KPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSA 1028
Query: 891 SYAGSAVAYLPDHRKAIHAAGLIFHLFT-YPAIMPYDSSQGKRNIKNGEIELKNVSFEYA 715
+ G A +Y P + KA +A F L P I Y+++ K + G+I+ + F Y
Sbjct: 1029 TALGRAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYP 1088
Query: 714 QRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVN 535
R D +L+G+S+ + G+TLA VG SG GKST I LLERFY G+V ID + VN
Sbjct: 1089 SRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVN 1148
Query: 534 LHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLE-IDQALKVANAFSFVSQFPQGL 358
+ LR ++ +VSQEPVLF CSI +N +G + +E + A K A FV P+
Sbjct: 1149 VQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKY 1208
Query: 357 DTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERL 178
+T VG +G+QLS G+KQRIAIARAI+R+PK+LLLDEATSALD++SEK VQ ALD A E
Sbjct: 1209 ETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGR 1268
Query: 177 STVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLV 40
+ +V+AHRLST+ NAD IAV+ G V E+GTHEEL+ ++ Y++LV
Sbjct: 1269 TCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLV 1314
Score = 305 bits (781), Expect = 6e-81
Identities = 181/509 (35%), Positives = 284/509 (55%), Gaps = 4/509 (0%)
Frame = -1
Query: 1536 FFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVD 1357
+ Q F+ A + K+R F+ +M + ++D C++ L+ R + D + + A+
Sbjct: 157 YIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFD--CNSVGELNTRFSDDINKINDAIA 214
Query: 1356 DRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAF 1177
D++ I + + + ++ FF WK++L ++ PL+ + V + + + A+
Sbjct: 215 DQMALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAY 274
Query: 1176 EKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYF 997
K+ A E + ++RTV A E R + +L + ++ ++ G GF F
Sbjct: 275 AKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIF 334
Query: 996 FIYAVSFKFGTWLVLRE-EILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIF 820
YA++F +G+ LVL E E P + +++ + A G+A L AA IF
Sbjct: 335 LCYALAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIF 394
Query: 819 HLFTYPAIMPYDSSQG-KRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALV 643
I+ S G K + GEIE NV+F Y R + IL+ +++ + G ALV
Sbjct: 395 ETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALV 454
Query: 642 GPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKE 463
GPSG+GKST + L++RFY +G V +D ++ +N+ LR+ + +V QEPVLF+ +I E
Sbjct: 455 GPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAE 514
Query: 462 NFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAI 283
N +G +A+ +I QA K ANA++F+ PQ DTLVGE G Q+SGGQKQR+AIARA+
Sbjct: 515 NIRYG-REDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARAL 573
Query: 282 LRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGK 103
+RNPK+LLLD ATSALD++SE +VQ L + + VAHRLSTV AD+I ++G
Sbjct: 574 IRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGT 633
Query: 102 VAEQGTHEELLRKRSIYWRLV--QKQGIQ 22
E+GTHEELL ++ +Y+ LV Q QG Q
Sbjct: 634 AVERGTHEELLERKGVYFTLVTLQSQGNQ 662
Score = 291 bits (746), Expect = 6e-77
Identities = 185/524 (35%), Positives = 281/524 (53%), Gaps = 4/524 (0%)
Frame = -1
Query: 3489 SDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGM-- 3316
S +N V LLF +G FLQ G+ +R+ +L +DI++FD +
Sbjct: 793 SQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRN 852
Query: 3315 STGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIV 3136
S G L+ L + + + +I +I+ T+ + I+AF W+L+ F +
Sbjct: 853 SPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLA 912
Query: 3135 LSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEK 2956
LSG + + + + G I +AL +TV+ + +++ +E EL+ K
Sbjct: 913 LSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELEKPFK 972
Query: 2955 YALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLG 2776
A+ +A ++ + N +G +I + V R++ ++ + LG
Sbjct: 973 TAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALG 1032
Query: 2775 EAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIKDTFQGIISFKNVLFSYPTRPD 2596
A + A A +L + + E D FQG I F + F+YP+RPD
Sbjct: 1033 RAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPD 1092
Query: 2595 VPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQL 2416
VL +S ++ G+ +A VG+SG GKST IQLL +Y+ D G++ IDG+D +N++ L
Sbjct: 1093 SQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFL 1152
Query: 2415 RQAMGVVFQEPVLFNTSIEENIRFGK--PDATEQEIIDALKNANAFDFVCNFPDGIKTIV 2242
R +G+V QEPVLF SI +NI++G + + +I A K A DFV + P+ +T V
Sbjct: 1153 RSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNV 1212
Query: 2241 GERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIV 2062
G +G+QLS G+KQRIAIAR +VR+P+ILLLDEATSALD ESE VQ AL KA GRT IV
Sbjct: 1213 GSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIV 1272
Query: 2061 VAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQT 1930
+AHRLSTI+NA+ I VM +G ++E G H++L+A G Y LV T
Sbjct: 1273 IAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLVTT 1316
>gi|17567265|ref|NP_510126.1| P-GlycoProtein related (pgp-12)
[Caenorhabditis elegans]
gi|7499663|pir||T21266 hypothetical protein F22E10.1 - Caenorhabditis
elegans
gi|3876291|emb|CAA91799.1| Hypothetical protein F22E10.1
[Caenorhabditis elegans]
Length = 1318
Score = 684 bits (1766), Expect = 0.0
Identities = 432/1270 (34%), Positives = 682/1270 (53%), Gaps = 55/1270 (4%)
Frame = -1
Query: 3669 RYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFE 3490
R + L G+ S ++G+ QP G + L+ I+N T D ++
Sbjct: 87 RTDYALLCFGIFLSFISGIAQPGLGIIAGNITNSLL-----IHNATSDD--------FYD 133
Query: 3489 SDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMST 3310
S M V LF +G F+Q+ ++ +++ YI +LR++ +FD +
Sbjct: 134 SAMTNV-WLFGGIGIIVLIVNFVQYMCFQYCCIRITSKMKQHYIQSILRQNAGWFDKNHS 192
Query: 3309 GHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLS 3130
G L+ L+DNMER E +K+ ++I + FV G +++F+ +WRLA +
Sbjct: 193 GTLTTKLHDNMERINEGIGDKLGVLIRGMVMFVAGIVISFFYEWRLALMMMGIGPLCCVC 252
Query: 3129 GLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYA 2950
L S K+ + AGSIA ++L +TV + NGQ++ VE+YT EL G+ +A
Sbjct: 253 MSLMSRSMSSFTSKELAGVGKAGSIAEESLMGVRTVQAFNGQEEMVEKYTVELGKGKSFA 312
Query: 2949 LNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTI-------EPGVVVRILYYILFG 2791
+ + + F L F+ YFG + Y G + PG V ++ +L G
Sbjct: 313 IQKGLWGGV------FGGIFLLFLFSYFGGGIYYGGQLLRWKIIETPGDVFIVVISMLIG 366
Query: 2790 SYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIKDT-FQGIISFKNVLFS 2614
+Y LG H+ L +A I +I+ D D + +E K T G + F+ V F
Sbjct: 367 AYFLGLISPHLMVLLNARVAAATIYEII-DRTPDIDVYSTEGQKMTNVVGKVVFEEVHFR 425
Query: 2613 YPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYN 2434
YPTR V VL ++ V+ G +ALVG SG GKST + LL Y + G++ IDG D+ +
Sbjct: 426 YPTRKKVKVLNGLNLTVKPGTSVALVGHSGCGKSTSVGLLTRLYEPEGGKVMIDGQDVRS 485
Query: 2433 INIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGI 2254
+NI LR+ +G+V QEP+LFN +I N+ G P AT +++I K ANA DF+ P+G
Sbjct: 486 LNIDWLRKTVGIVQQEPILFNDTIHNNLLIGNPSATREDMIRVCKMANAHDFIQKMPNGY 545
Query: 2253 KTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGR 2074
+T++G+ QLSGGQKQR+AIARTL+R+P++LLLDEATSALD +SE +VQ AL A+ GR
Sbjct: 546 ETMIGDGSVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESVVQSALNNAAKGR 605
Query: 2073 TTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTN---YEK 1903
TTI++AHRLSTIR A+KI+ E G IVE G+H++L+A+ G Y LV+ Q + +
Sbjct: 606 TTIMIAHRLSTIREADKIVFFENGVIVESGNHEELVALGGRYAKLVEAQKFKESDDIEDN 665
Query: 1902 MNENEERVTRQSSHSDFPSNEISH----------------------------QKIDQEDD 1807
+E+EE + H S ++S Q+ + +D
Sbjct: 666 GDEHEEETSTVGRHDRLSSRQVSFHKSCESLASADLEIGYASTFNTFTLKTAQEEIENED 725
Query: 1806 YVKKLIAEIKEEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEA 1627
+ +++ ++E+G S +I K + Y L + + ++G L + + + A
Sbjct: 726 FAEEVQRVMEEDGVINSGYLDIFKNAQGNYLYLSVGTFFAILRGSELALLANMFGFVFAA 785
Query: 1626 YAFDKDEMLSKSHFWALSILFLAFTR-PIFIFFQYYFFGK----TAEKLSIKLRSMSFKH 1462
+ +DEM+ AL ++F+ + +F+F G AE L +K R SFK+
Sbjct: 786 FKEPEDEMVK-----ALGLIFILYVALGLFVFITQVISGTLFTIVAENLGLKFRVQSFKN 840
Query: 1461 LMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSW 1282
L+ +F+D+P H +L RL +D+ NV A VD R+ VI ++ +I + +I + + W
Sbjct: 841 LLYQDASFFDNPAHAPGKLITRLASDAPNVKAVVDTRMLQVIYSITSITINLITGYIFCW 900
Query: 1281 KM----SLQVLMFCPLLYLAGY--CNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRA 1120
++ ++ +++F ++ Y +N I +++ + AIE +E+V+T++
Sbjct: 901 RIAIAGTIMIVLFATMMISMAYKIARENL-------KQIRKDEAGKIAIEIIESVKTIQL 953
Query: 1119 LNMENRVI-----LLVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLV 955
L R + + H ++R SY IQ N + + +F V + GT L+
Sbjct: 954 LTSTQRFLTHYKDAQLVQHKSEMRKSY-----IQSVNNAISQTFMYFAMFVCYGVGTPLM 1008
Query: 954 LREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQ 775
+ T+ + + M + + P+ KA AAG++F L Y D +
Sbjct: 1009 YHGIVEAEPTFRAINCMMMGSVAVMHSSHNFPEFVKAKTAAGMLFKLI-YRKSKTGDVME 1067
Query: 774 GKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLER 595
G G + ++V F Y QR + ++ + +G+T+ALVGPSG+GKST I++LER
Sbjct: 1068 GNNTEIRGNVLFESVKFSYPQRPMQPVMTDLHFSAHSGQTVALVGPSGTGKSTCIAMLER 1127
Query: 594 FYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEID 415
FY G ++ID +N+ ++LHHLR ++LV QEP LF +IKEN FG+ + S ++
Sbjct: 1128 FYDVSGGALRIDGQNIKSLSLHHLRTQMALVGQEPRLFAGTIKENVCFGLK-DVSVEKVH 1186
Query: 414 QALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSAL 235
QAL++ANA F++ P G+DT VGE+G QLSGGQKQRIAIARA++R+PK+LLLDEATSAL
Sbjct: 1187 QALELANASRFLANLPAGIDTEVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSAL 1246
Query: 234 DSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSI 55
DS+SE+ VQ ALD A E + + +AHRLS++ N+D I + +G V E G H L+ R
Sbjct: 1247 DSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDHGMVQEAGNHAHLMSLRGK 1306
Query: 54 YWRLVQKQGI 25
Y+ L++KQ +
Sbjct: 1307 YYNLIKKQDL 1316
Score = 297 bits (761), Expect = 1e-78
Identities = 183/537 (34%), Positives = 289/537 (53%), Gaps = 6/537 (1%)
Frame = -1
Query: 3507 AYKLFESDMNRVVLLFFLVGFAYFTFGFL----QFSIMKFVGDNTAYNVRRQYISRLLRK 3340
A+K E +M + + L F++ A F F+ ++ V +N R Q LL +
Sbjct: 785 AFKEPEDEMVKALGLIFILYVALGLFVFITQVISGTLFTIVAENLGLKFRVQSFKNLLYQ 844
Query: 3339 DISYFDGMS--TGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLAC 3166
D S+FD + G L L + + V + ++ +I +T I I + WR+A
Sbjct: 845 DASFFDNPAHAPGKLITRLASDAPNVKAVVDTRMLQVIYSITSITINLITGYIFCWRIAI 904
Query: 3165 YGTVFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVER 2986
GT+ + ++ + N KQ AG IA + + KT+ L Q+ +
Sbjct: 905 AGTIMIVLFATMMISMAYKIARENLKQIRK-DEAGKIAIEIIESVKTIQLLTSTQRFLTH 963
Query: 2985 YTEELKNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILY 2806
Y + K + ++++ S++ + F FV G ++Y G +E R +
Sbjct: 964 YKDAQLVQHKSEMRKSYIQSVNNAISQTFMYFAMFVCYGVGTPLMYHGIVEAEPTFRAIN 1023
Query: 2805 YILFGSYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIKDTFQGIISFKN 2626
++ GS + + + A + ++ T D E +G + F++
Sbjct: 1024 CMMMGSVAVMHSSHNFPEFVKAKTAAGMLFKLIYRKSKTGDVM--EGNNTEIRGNVLFES 1081
Query: 2625 VLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGN 2446
V FSYP RP PV+ ++ F+ G+ +ALVG SG+GKST I +L +Y++ G + IDG
Sbjct: 1082 VKFSYPQRPMQPVMTDLHFSAHSGQTVALVGPSGTGKSTCIAMLERFYDVSGGALRIDGQ 1141
Query: 2445 DIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNF 2266
+I ++++ LR M +V QEP LF +I+EN+ FG D + +++ AL+ ANA F+ N
Sbjct: 1142 NIKSLSLHHLRTQMALVGQEPRLFAGTIKENVCFGLKDVSVEKVHQALELANASRFLANL 1201
Query: 2265 PDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKA 2086
P GI T VGE+G QLSGGQKQRIAIAR LVR+P+ILLLDEATSALD+ESE VQEAL +A
Sbjct: 1202 PAGIDTEVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRA 1261
Query: 2085 SIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMST 1915
GRT I +AHRLS+I+N++ I+ ++ G + E G+H L+++ G Y NL++ Q ++T
Sbjct: 1262 REGRTCITIAHRLSSIQNSDLIVYIDHGMVQEAGNHAHLMSLRGKYYNLIKKQDLTT 1318
Score = 291 bits (744), Expect = 1e-76
Identities = 190/604 (31%), Positives = 322/604 (52%), Gaps = 12/604 (1%)
Frame = -1
Query: 1779 KEEGAKKSNICEIIKYC-RSEYCILFIAVLGSAIQGIYYP--------LSSQLMIKSYEA 1627
+E K + + +Y R++Y +L + S I GI P +++ L+I + +
Sbjct: 69 RELSVKPVTLLGLFRYAERTDYALLCFGIFLSFISGIAQPGLGIIAGNITNSLLIHNATS 128
Query: 1626 YAFDKDEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLP 1447
F M + F + I+ L I F QY F +++ K++ + ++
Sbjct: 129 DDFYDSAMTNVWLFGGIGIIVL-----IVNFVQYMCFQYCCIRITSKMKQHYIQSILRQN 183
Query: 1446 CAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQ 1267
++D H+ T L+ +L+ + + + D+LG +I +V + +++SFFY W+++L
Sbjct: 184 AGWFDKN-HSGT-LTTKLHDNMERINEGIGDKLGVLIRGMVMFVAGIVISFFYEWRLALM 241
Query: 1266 VLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLV 1087
++ PL + + ++ K+ A E+L VRTV+A N + ++
Sbjct: 242 MMGIGPLCCVCMSLMSRSMSSFTSKELAGVGKAGSIAEESLMGVRTVQAFNGQEEMVEKY 301
Query: 1086 TSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEIL--PMDTYLVL 913
T L K ++ ++ + G G F + +G L LR +I+ P D ++V+
Sbjct: 302 TVELGKGKSFAIQKGLWGGVFGGIFLLFLFSYFGGGIYYGGQL-LRWKIIETPGDVFIVV 360
Query: 912 MTLSMTASYAGSAVAYLPDHRKAIHAAGLIFHLFTY-PAIMPYDSSQGKRNIKNGEIELK 736
+++ + A + G +L A AA I+ + P I Y + K G++ +
Sbjct: 361 ISMLIGAYFLGLISPHLMVLLNARVAAATIYEIIDRTPDIDVYSTEGQKMTNVVGKVVFE 420
Query: 735 NVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDE 556
V F Y R +L+G++L + G ++ALVG SG GKST + LL R Y G+V ID
Sbjct: 421 EVHFRYPTRKKVKVLNGLNLTVKPGTSVALVGHSGCGKSTSVGLLTRLYEPEGGKVMIDG 480
Query: 555 ENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVS 376
++V +N+ LR++V +V QEP+LFN +I N L G + +A++ ++ + K+ANA F+
Sbjct: 481 QDVRSLNIDWLRKTVGIVQQEPILFNDTIHNNLLIG-NPSATREDMIRVCKMANAHDFIQ 539
Query: 375 QFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALD 196
+ P G +T++G+ QLSGGQKQR+AIAR ++R+PKVLLLDEATSALD+ SE VVQ+AL+
Sbjct: 540 KMPNGYETMIGDGSVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESVVQSALN 599
Query: 195 TASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQVE 16
A++ +T+++AHRLST+ AD I +NG + E G HEEL+ Y +LV+ Q +
Sbjct: 600 NAAKGRTTIMIAHRLSTIREADKIVFFENGVIVESGNHEELVALGGRYAKLVEAQKFKES 659
Query: 15 TLIE 4
IE
Sbjct: 660 DDIE 663
>gi|14030565|gb|AAK52958.1| bile salt export pump [Raja erinacea]
Length = 1348
Score = 684 bits (1766), Expect = 0.0
Identities = 429/1272 (33%), Positives = 678/1272 (52%), Gaps = 63/1272 (4%)
Frame = -1
Query: 3666 YEKLLFFLGVVFSILTGMCQPFESYTLGETS----------QVLVKVTNAINNKTIDPVD 3517
YE L G V ++L G+ QP G + Q L +N TI V+
Sbjct: 74 YEVTLMVFGGVCALLHGVAQPAVLLVFGLLTDTFIAYDIELQELKDTRKHCDNNTIHWVN 133
Query: 3516 -----------LAHAYKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVR 3370
++ E +M + +G + G+ Q +R
Sbjct: 134 GSEYLNQHNETMSCGILNIEKEMTMFAYYYVGIGCSVLLLGYFQICFWVTAAARQTQKIR 193
Query: 3369 RQYISRLLRKDISYFDGMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAF 3190
+ Y +++R ++ +FD S G L+ ++D++ + + +++ + I + FV G ++ F
Sbjct: 194 KAYFRQIMRMEMGWFDCNSVGELNTRMSDDINKINDAIADQVGIFIQRFSTFVSGFLMGF 253
Query: 3189 YTDWRLACYGTVFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLN 3010
W+L S I L L + + + + AG++A + L +TV++ +
Sbjct: 254 VNGWKLTLVIIAVSPLIGLGAALMALSVARLTGLGLKAYAKAGAVADEVLSSIRTVAAFS 313
Query: 3009 GQQQEVERYTEELKNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYE-GTIE 2833
G+++EV+RY L +++ + + + + + ++G+ ++ E
Sbjct: 314 GEKKEVDRYDRNLVFAQRWGIRKGMIMGFFTGYVWMIIFCCYALAFWYGSKLVIEQNEYT 373
Query: 2832 PGVVVRILYYILFGSYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEE--IK 2659
PG ++++ +L + LG+A + AS V I + + D + D SE
Sbjct: 374 PGGLLQVFLGVLVAAMNLGQASPCLEAFASGRGAAVKIFETI-DREPEID-CMSEGGYTL 431
Query: 2658 DTFQGIISFKNVLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYN 2479
+ +G I F NV F+YP+RPDV L +S ++ GE A VG SGSGKST ++L+ +Y+
Sbjct: 432 NKVKGDIEFHNVTFNYPSRPDVKTLDRLSMVIKAGETTAFVGPSGSGKSTAVELIQRFYD 491
Query: 2478 IDSGRISIDGNDIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALK 2299
G +++DG+DI ++NI+ LR +G+V QEPVLF+T+IEENIR+ + T+ +I+ A K
Sbjct: 492 PKQGMVTLDGHDIRSLNIQWLRSLIGIVEQEPVLFSTTIEENIRYVREGLTKNDIVQAAK 551
Query: 2298 NANAFDFVCNFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNES 2119
ANA+DF+ + P+ T+VGE G Q+SGGQKQRIAIAR LVRNP+ILLLD ATSALDNES
Sbjct: 552 EANAYDFIMDLPEKFNTLVGEGGGQMSGGQKQRIAIARALVRNPKILLLDMATSALDNES 611
Query: 2118 EFIVQEALQKASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNL 1939
E IVQ AL K GRTTI +AHRLST+RN + II E G VE G H +L+ G+Y L
Sbjct: 612 EAIVQGALDKVRFGRTTISIAHRLSTVRNVDVIIGFEHGRAVERGRHAELLERKGIYFTL 671
Query: 1938 V--QTQLMSTNYEKM-----------NENEERVTRQSSHSDFPSNEISHQKIDQEDDYVK 1798
V QTQ +EK +E + + R SS + S HQ+ + V
Sbjct: 672 VTLQTQGEQALHEKARQVNGAIEDGASEKRQLIRRGSSRASVRSTR--HQRSRSQVSEVL 729
Query: 1797 KLIA-----------------------EIKEEGAKKSNICEIIKYCRSEYCILFIAVLGS 1687
++ E +EE + + + I+KY SE+ + LG+
Sbjct: 730 SDLSGPGDVASAVRTPSISLGDEDKDVEEEEESIEPAPVSRILKYNVSEWPYMLFGSLGA 789
Query: 1686 AIQGIYYPLSSQLMIKSYEAYAF-DKDEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGK 1510
A+ G P+ + L + ++ +++E +++ + L + + + F Q YFF K
Sbjct: 790 AVNGGVNPIYALLFSQILGTFSLQNEEEKINQINAICLFFVVVGLVSFLTQFLQSYFFAK 849
Query: 1509 TAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMT 1330
+ E L+ +LR + F+ ++ ++DD ++ L+ RL D+S V A ++G ++ +
Sbjct: 850 SGELLTRRLRKLGFQAMLRQEIGWFDDRKNSPGTLTTRLATDASQVQGATGTQIGMIVNS 909
Query: 1329 LVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIE 1150
+ I +++I++F++SWK++L +L F P L L G + +D A E + + + E
Sbjct: 910 ITNIGVSLIIAFYFSWKLTLVILCFLPFLALTGALQARMLTGFANQDKEALEAAGQISSE 969
Query: 1149 ALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKF 970
AL N+RT+ L E + L + L+ + K+A + G GFA S F A S++F
Sbjct: 970 ALSNIRTIAGLAKEKMFVQLFEAQLEAPYKAAIKKANVYGLCFGFAQSVIFLANAASYRF 1029
Query: 969 GTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFHLFTYPAIMP 790
G +LV+ E + + V+ + + + G A +Y PD+ KA AA F L +
Sbjct: 1030 GGYLVVAENLHFSIVFRVISAIVTSGTALGRASSYTPDYAKAKIAAARFFQLIDRAPKIN 1089
Query: 789 YDSSQGKR-NIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTI 613
DSS+G++ + G+I+ +F Y R D +L+G+S+ + G+TLA VG SG GKST
Sbjct: 1090 IDSSEGEKWSNFRGDIKFVECTFTYPTRPDFQVLNGLSVCVMPGQTLAFVGSSGCGKSTS 1149
Query: 612 ISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFG-ISHN 436
+ LLERFY G V ID + +VN LR + +VSQEPVLF+ SI+EN +G S
Sbjct: 1150 VQLLERFYDPNQGRVIIDGRSTTNVNTAFLRSKIGIVSQEPVLFDSSIEENIKYGDNSRQ 1209
Query: 435 ASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLL 256
S E+ A K A SFV P+ T VG +G+QLS GQKQRIAIARAI+R+PK+LLL
Sbjct: 1210 VSMDEVIAAAKKAQLHSFVMSLPEKYGTRVGAQGSQLSRGQKQRIAIARAIVRDPKILLL 1269
Query: 255 DEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEE 76
DEATSALD++SEK+VQ+ALD A + + +V+AHRLST+ N+D IAV+ G + EQG+H
Sbjct: 1270 DEATSALDTESEKIVQDALDEARKGRTCIVIAHRLSTIQNSDIIAVMSRGIIIEQGSHGN 1329
Query: 75 LLRKRSIYWRLV 40
L+ + Y++LV
Sbjct: 1330 LMAAKGAYYKLV 1341
Score = 301 bits (772), Expect = 6e-80
Identities = 192/527 (36%), Positives = 285/527 (53%), Gaps = 7/527 (1%)
Frame = -1
Query: 3489 SDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGM-- 3316
+ +N + L F +VG F FLQ G+ +R+ +LR++I +FD
Sbjct: 820 NQINAICLFFVVVGLVSFLTQFLQSYFFAKSGELLTRRLRKLGFQAMLRQEIGWFDDRKN 879
Query: 3315 STGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIV 3136
S G L+ L + + + +I +I+ +T+ + I+AFY W+L F +
Sbjct: 880 SPGTLTTRLATDASQVQGATGTQIGMIVNSITNIGVSLIIAFYFSWKLTLVILCFLPFLA 939
Query: 3135 LSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEK 2956
L+G L + + E + AG I+ +AL +T++ L ++ V+ + +L+ K
Sbjct: 940 LTGALQARMLTGFANQDKEALEAAGQISSEALSNIRTIAGLAKEKMFVQLFEAQLEAPYK 999
Query: 2955 YALNRAFVFSLS---RSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSY 2785
A+ +A V+ L + F NA ++ FG ++ + +V R++ I+
Sbjct: 1000 AAIKKANVYGLCFGFAQSVIFLANAASY---RFGGYLVVAENLHFSIVFRVISAIVTSGT 1056
Query: 2784 CLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIKDTFQGIISFKNVLFSYPT 2605
LG A + A A ++ + + E F+G I F F+YPT
Sbjct: 1057 ALGRASSYTPDYAKAKIAAARFFQLIDRAPKINIDSSEGEKWSNFRGDIKFVECTFTYPT 1116
Query: 2604 RPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINI 2425
RPD VL +S V G+ +A VG+SG GKST +QLL +Y+ + GR+ IDG N+N
Sbjct: 1117 RPDFQVLNGLSVCVMPGQTLAFVGSSGCGKSTSVQLLERFYDPNQGRVIIDGRSTTNVNT 1176
Query: 2424 KQLRQAMGVVFQEPVLFNTSIEENIRFG--KPDATEQEIIDALKNANAFDFVCNFPDGIK 2251
LR +G+V QEPVLF++SIEENI++G + E+I A K A FV + P+
Sbjct: 1177 AFLRSKIGIVSQEPVLFDSSIEENIKYGDNSRQVSMDEVIAAAKKAQLHSFVMSLPEKYG 1236
Query: 2250 TIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRT 2071
T VG +G+QLS GQKQRIAIAR +VR+P+ILLLDEATSALD ESE IVQ+AL +A GRT
Sbjct: 1237 TRVGAQGSQLSRGQKQRIAIARAIVRDPKILLLDEATSALDTESEKIVQDALDEARKGRT 1296
Query: 2070 TIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQT 1930
IV+AHRLSTI+N++ I VM +G I+E G H L+A G Y LV T
Sbjct: 1297 CIVIAHRLSTIQNSDIIAVMSRGIIIEQGSHGNLMAAKGAYYKLVTT 1343
Score = 298 bits (762), Expect = 9e-79
Identities = 183/509 (35%), Positives = 278/509 (53%), Gaps = 4/509 (0%)
Frame = -1
Query: 1536 FFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVD 1357
+FQ F+ A + + K+R F+ +M + ++D C++ L+ R++ D + + A+
Sbjct: 175 YFQICFWVTAAARQTQKIRKAYFRQIMRMEMGWFD--CNSVGELNTRMSDDINKINDAIA 232
Query: 1356 DRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAF 1177
D++G I + +M F WK++L ++ PL+ L V + A+
Sbjct: 233 DQVGIFIQRFSTFVSGFLMGFVNGWKLTLVIIAVSPLIGLGAALMALSVARLTGLGLKAY 292
Query: 1176 EKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYF 997
K+ A E L ++RTV A + E + + +L + ++ +I G G+ F
Sbjct: 293 AKAGAVADEVLSSIRTVAAFSGEKKEVDRYDRNLVFAQRWGIRKGMIMGFFTGYVWMIIF 352
Query: 996 FIYAVSFKFGTWLVLRE-EILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIF 820
YA++F +G+ LV+ + E P V + + + A G A L AA IF
Sbjct: 353 CCYALAFWYGSKLVIEQNEYTPGGLLQVFLGVLVAAMNLGQASPCLEAFASGRGAAVKIF 412
Query: 819 HLFTYPAIMPYDSSQGKR-NIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALV 643
+ S G N G+IE NV+F Y R D LD +S+ + AG T A V
Sbjct: 413 ETIDREPEIDCMSEGGYTLNKVKGDIEFHNVTFNYPSRPDVKTLDRLSMVIKAGETTAFV 472
Query: 642 GPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKE 463
GPSGSGKST + L++RFY G V +D ++ +N+ LR + +V QEPVLF+ +I+E
Sbjct: 473 GPSGSGKSTAVELIQRFYDPKQGMVTLDGHDIRSLNIQWLRSLIGIVEQEPVLFSTTIEE 532
Query: 462 NFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAI 283
N + + ++ +I QA K ANA+ F+ P+ +TLVGE G Q+SGGQKQRIAIARA+
Sbjct: 533 NIRY-VREGLTKNDIVQAAKEANAYDFIMDLPEKFNTLVGEGGGQMSGGQKQRIAIARAL 591
Query: 282 LRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGK 103
+RNPK+LLLD ATSALD++SE +VQ ALD +T+ +AHRLSTV N D I ++G+
Sbjct: 592 VRNPKILLLDMATSALDNESEAIVQGALDKVRFGRTTISIAHRLSTVRNVDVIIGFEHGR 651
Query: 102 VAEQGTHEELLRKRSIYWRLV--QKQGIQ 22
E+G H ELL ++ IY+ LV Q QG Q
Sbjct: 652 AVERGRHAELLERKGIYFTLVTLQTQGEQ 680
>gi|18496818|gb|AAL74250.1| ABC transporter AbcB3 [Dictyostelium
discoideum]
Length = 1432
Score = 682 bits (1761), Expect = 0.0
Identities = 433/1274 (33%), Positives = 668/1274 (51%), Gaps = 63/1274 (4%)
Frame = -1
Query: 3663 EKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFESD 3484
+K+L FLG + +++ G P S G K T ++ D D + +
Sbjct: 176 DKVLMFLGTIAAVINGAAMPTVSLVFGLVVDAF-KPTQFNDDPNYDIYDTVRSISFY--- 231
Query: 3483 MNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMSTGH 3304
++G F +L+ ++ G+ +RR+Y+ LR++I +FD
Sbjct: 232 -------LLMLGGGVFVLSYLETTLWMIAGERQTSRIRREYLESTLRQEIGWFDTNKANE 284
Query: 3303 LSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGL 3124
LS +N + F E EK+ I + FV G ++ F W+L T S + + G
Sbjct: 285 LSSRINSDTVLFEEAIGEKVGRFIHFFSTFVAGFVIGFTKGWQLTLVITSVSPLLAIGGF 344
Query: 3123 LDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALN 2944
+ + + E S AG +A + +G +TV++ +G++ +++Y+ LK+
Sbjct: 345 FTAKMMTQMTKLGQEAYSRAGGVAEENIGSIRTVATFSGEKLAIDKYSNNLKDARTVGYK 404
Query: 2943 RAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEP--------GVVVRILYYILFGS 2788
R+F L F + ++G+ +I G VV + + ++ G+
Sbjct: 405 RSFFNGLGLGFVQFVILGTYALAFWYGSTLISNKVTNSVSDRPWTGGDVVSVFFAVIIGA 464
Query: 2787 YCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSY 2611
+G+A ++ A I ++ D + A+ F + IK +T G I FK+V F Y
Sbjct: 465 TSIGQASPCLALFAQGRGAAYKIFQVI-DRQSKANPFSTRGIKPETLSGEIEFKDVGFHY 523
Query: 2610 PTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNI 2431
P+RPDVP+ + ++ G+ + LVG SG GKST+I LL +Y+ G I +DG DI
Sbjct: 524 PSRPDVPIFNGFNLKIKPGQTVGLVGDSGGGKSTIISLLERFYDPCQGEILLDGEDIRKF 583
Query: 2430 NIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIK 2251
N++ LRQ +G+V QEPVLF T+I ENIR+GK AT+ EI +A K ANA F+ P G
Sbjct: 584 NVRGLRQKIGLVNQEPVLFATTISENIRYGKEGATQDEIEEAAKLANAHSFISQLPQGYN 643
Query: 2250 TIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRT 2071
T+VGE+G Q+SGGQ+QRIAIAR +++NP ILLLDE+TSALD ES +VQEAL GRT
Sbjct: 644 TLVGEKGVQMSGGQRQRIAIARAVIKNPNILLLDESTSALDAESTKLVQEALDVLMKGRT 703
Query: 2070 TIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNEN 1891
TIV+AH LSTIRNA+ II ++KG VE G H +L+A G+Y +LV+ Q Y + EN
Sbjct: 704 TIVIAHNLSTIRNADVIIYIKKGVAVERGTHDELMAKQGLYFDLVEKQSHQQMYNLL-EN 762
Query: 1890 EERVTRQSSHS---------------DFPSNEISHQKIDQEDDYVKKLIAEIKEEGAKKS 1756
R R S+ S NE K D+ED KK K++ ++
Sbjct: 763 GTRSRRSSTFSAEVNPLLDSFHVSKRSLRKNESESNKKDKEDSNNKKKKKSNKKK-VEEV 821
Query: 1755 NICEIIKYCRSE---YCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAF-DKDEMLSKSH 1588
+ ++KY R E +C F++ +G+ G YP + + + + D + + ++
Sbjct: 822 PMSRVVKYNRPELGLWCFGFLSAVGT---GAVYPGFAMVFTEMLTIFQNPDPNYLTDHAN 878
Query: 1587 FWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATR 1408
F AL + LA I FFQ + F EKL+ +LR F +M ++D P ++ +
Sbjct: 879 FVALMFVALAVGAGISNFFQGFLFSVIGEKLTYRLRRDCFAAIMRQDVGWFDLPENSTGK 938
Query: 1407 LSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGY 1228
L++ L D++ V RLG V+ ++ ++ ++++F+ W+++L ++ PL+ +
Sbjct: 939 LTSHLATDAALVQGMTSQRLGIVLQNILTMVGGLVIAFYSGWQLTLVIIACFPLVVITSK 998
Query: 1227 CNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFK 1048
+ +D + + A EA+ +RTV + E +V+ L + + K
Sbjct: 999 VQMQILAGFSSKDGCG--PAGQVASEAISGIRTVASFTTEKQVVELYKKQQKGPSSEGIK 1056
Query: 1047 RAVIQGTANGFACSCYFFIYAVSFKFGTWLV-----------LREEILPMD-TYL----- 919
+A I G A GF F +Y +SF +G LV + + P YL
Sbjct: 1057 KAHISGFAFGFTQLILFCVYCLSFWYGGKLVGSGVFGATDKEISDNCTPQTIPYLWKDYD 1116
Query: 918 -----------------VLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFHLFTYPAIMP 790
V + M+A G A ++ PD KA AA +F L P+ +
Sbjct: 1117 TCERAQNTIYGFNSMTRVFFAIVMSAIGVGQASSFAPDLAKAKAAAVSVFKLLDTPSKID 1176
Query: 789 YDSSQGKR-NIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTI 613
+ G R +I G+IE KN+ F Y R D + G +L L +G T ALVG SG GKST
Sbjct: 1177 PTTEDGDRIDIVGGDIEFKNLHFSYPTRPDNSVFRGFTLTLQSGTTTALVGDSGGGKSTC 1236
Query: 612 ISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNA 433
+SLL+RFY+ V GE+ ID N+ ++N+ HLR LV QEP LF+ +I +N +G H+A
Sbjct: 1237 LSLLQRFYNPVVGEIFIDGHNIKNLNVRHLRHLFGLVGQEPTLFSGTIADNIRYG-KHDA 1295
Query: 432 SQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLD 253
+Q EI++A K++N+ SF+ P G +T +GE+ QLSGGQKQRIAIARAI+RNPK+LLLD
Sbjct: 1296 TQEEIEEASKLSNSHSFIIDLPNGYNTELGEKYTQLSGGQKQRIAIARAIIRNPKILLLD 1355
Query: 252 EATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEEL 73
E+TSALD+DS K+VQ AL+ + +T+V+AH L T+ NAD IA ++ G++ E+GTH+EL
Sbjct: 1356 ESTSALDADSTKLVQEALENVMKGRTTIVIAHNLLTIQNADCIAYVRAGQIIERGTHDEL 1415
Query: 72 LRKRSIYWRLVQKQ 31
L Y +L Q
Sbjct: 1416 LEAEGPYSQLWYNQ 1429
Score = 329 bits (844), Expect = 3e-88
Identities = 208/662 (31%), Positives = 353/662 (52%), Gaps = 16/662 (2%)
Frame = -1
Query: 1959 NGVYNNLVQTQLMSTNYEKMNENEERVTRQSSHSDFPSNEISHQKIDQEDDYVKKLIAEI 1780
N +NN + ++ E NEN + +++++ N+ + +++ E++ K E
Sbjct: 100 NNSFNNNKKNEVSIGISENTNENNNKNNNNNNNNNDDYNDGADERVKTEEEIKK----EA 155
Query: 1779 KEEGAKKSNICEIIKYC-RSEYCILFIAVLGSAIQGIYYPLSSQ---LMIKSYEAYAFDK 1612
+ E + + ++ ++ ++F+ + + I G P S L++ +++ F+
Sbjct: 156 ENELNQSVPFLSLFRFADNTDKVLMFLGTIAAVINGAAMPTVSLVFGLVVDAFKPTQFND 215
Query: 1611 DEMLS-KSHFWALSILFLAFTRPIFI--FFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCA 1441
D ++S L +F+ + + + E+ + ++R + +
Sbjct: 216 DPNYDIYDTVRSISFYLLMLGGGVFVLSYLETTLWMIAGERQTSRIRREYLESTLRQEIG 275
Query: 1440 FYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVL 1261
++D + A LS+R+N+D+ A+ +++G I + ++ F W+++L +
Sbjct: 276 WFDT--NKANELSSRINSDTVLFEEAIGEKVGRFIHFFSTFVAGFVIGFTKGWQLTLVIT 333
Query: 1260 MFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTS 1081
PLL + G+ + Q + A+ ++ A E + ++RTV + E I ++
Sbjct: 334 SVSPLLAIGGFFTAKMMTQMTKLGQEAYSRAGGVAEENIGSIRTVATFSGEKLAIDKYSN 393
Query: 1080 HLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPM--------DT 925
+L+ R +KR+ G GF YA++F +G+ L+ + + D
Sbjct: 394 NLKDARTVGYKRSFFNGLGLGFVQFVILGTYALAFWYGSTLISNKVTNSVSDRPWTGGDV 453
Query: 924 YLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFHLFTYPA-IMPYDSSQGKRNIKNGE 748
V + + A+ G A L + AA IF + + P+ + K +GE
Sbjct: 454 VSVFFAVIIGATSIGQASPCLALFAQGRGAAYKIFQVIDRQSKANPFSTRGIKPETLSGE 513
Query: 747 IELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEV 568
IE K+V F Y R D I +G +LK+ G+T+ LVG SG GKSTIISLLERFY GE+
Sbjct: 514 IEFKDVGFHYPSRPDVPIFNGFNLKIKPGQTVGLVGDSGGGKSTIISLLERFYDPCQGEI 573
Query: 567 KIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAF 388
+D E++ N+ LR+ + LV+QEPVLF +I EN +G A+Q EI++A K+ANA
Sbjct: 574 LLDGEDIRKFNVRGLRQKIGLVNQEPVLFATTISENIRYG-KEGATQDEIEEAAKLANAH 632
Query: 387 SFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQ 208
SF+SQ PQG +TLVGE+G Q+SGGQ+QRIAIARA+++NP +LLLDE+TSALD++S K+VQ
Sbjct: 633 SFISQLPQGYNTLVGEKGVQMSGGQRQRIAIARAVIKNPNILLLDESTSALDAESTKLVQ 692
Query: 207 NALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQG 28
ALD + +T+V+AH LST+ NAD I +K G E+GTH+EL+ K+ +Y+ LV+KQ
Sbjct: 693 EALDVLMKGRTTIVIAHNLSTIRNADVIIYIKKGVAVERGTHDELMAKQGLYFDLVEKQS 752
Query: 27 IQ 22
Q
Sbjct: 753 HQ 754
>gi|157873|gb|AAA16186.1| P-glycoprotein/multidrug resistance protein
Length = 1283
Score = 680 bits (1755), Expect = 0.0
Identities = 422/1252 (33%), Positives = 683/1252 (53%), Gaps = 26/1252 (2%)
Frame = -1
Query: 3708 LKKTFGFQI-KCTTRYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKT 3532
+K+ FQ+ + T+ ++ L+ +G++ ++ TG+ P S G + ++ ++ + +
Sbjct: 41 VKQVSYFQLFRYATKKDRALYVIGLLSAVGTGLTTPANSLIFGNLANDMIDLSGLLESGK 100
Query: 3531 IDPVDLAHAYKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISR 3352
D A + L + + + L +G +L + + + +R ++
Sbjct: 101 SYRADDAISTLLLDK-VRQFSLQNTYIGMIMLVCSYLSITCFNYAAHSQILTIRSKFFRS 159
Query: 3351 LLRKDISYFDGMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRL 3172
+L +D+ ++D +G ++ +N+++ + + EK+ + + L FV +LAF W+L
Sbjct: 160 ILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQL 219
Query: 3171 ACYG-TVFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQE 2995
+ T + GL+ + + +K+ + A +A AL +TV + G+ +E
Sbjct: 220 SLVCLTSLPLTFIAMGLV-AVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKE 278
Query: 2994 VERYTEELKNGEKYALNRAFVFSLSRSADYFFTNALNFVILY-FGANMIYEGTIE---PG 2827
V Y E + + + R + +FF ++ + + +G ++ E E G
Sbjct: 279 VAAYKERVVAAKILNIKRNMFSGIGFGLLWFFFIYASYALAFWYGVGLVIESAYENYDAG 338
Query: 2826 VVVRILYYILFGSYCLGEAILHISRLASA---IPLTVPIADILLDSDATADEFFSEEIKD 2656
++ + + ++ GS +G A +I A +P I + + + + E
Sbjct: 339 TMITVFFSVMMGSMNIGMAAPYIEAFGIAQGRLPKVFHIIEQIPEINPLMGRVKVNEPLT 398
Query: 2655 TFQGIISFKNVLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNI 2476
T I FK V F YPTRP+V +L +++ + G+ +ALVG SG GKST IQL+ +Y+
Sbjct: 399 T----IEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDP 454
Query: 2475 DSGRISIDGNDIYNINIKQLR-QAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALK 2299
+G + +G ++ +++I LR +GVV QEP+LF TSI ENIR+G+ DAT +EI A
Sbjct: 455 QAGNLLFNGTNLKDLDINWLRFLRIGVVGQEPILFATSIYENIRYGREDATREEIEAARA 514
Query: 2298 NANAFDFVCNFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNES 2119
ANA F+ P G T+VGERGAQLSGGQKQRIAI R L+R+P ILLLDEATSALD S
Sbjct: 515 AANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIRRALIRDPEILLLDEATSALDTAS 574
Query: 2118 EFIVQEALQKASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNL 1939
E VQ AL+K S GRTTI+VAHRLST+R A++I+V+ KGE+VE G H++L+ + Y NL
Sbjct: 575 EAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNL 634
Query: 1938 VQTQLMSTNYEKMNENEERVTRQSSHSDFPSNEISHQKIDQEDDYV-------KKLIAEI 1780
V TQL + ++ + + + D EI D+++D + KK + ++
Sbjct: 635 VTTQLGEDDGSVLSPTGD-IYKNFDIKDEDEEEIKVLSEDEDEDVMVTDEKNKKKKMKKV 693
Query: 1779 KEEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAF-DKDEM 1603
K+ K + E++K + E+ + + + S I G P+ + L + + D D+
Sbjct: 694 KDPNEVKP-MLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGSILQILSVKDNDQY 752
Query: 1602 L-SKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDP 1426
+ S+ ++L L I F Q YFFG E+L+ +LR + F+ ++ A++DD
Sbjct: 753 VRENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDK 812
Query: 1425 CHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPL 1246
+ L RL+ D++ V A R+G++I ++ + L + +S +Y W + L L F P
Sbjct: 813 ANGTGSLCARLSGDAAAVQGATGQRIGTIIQSISTLALGIALSMYYEWSLGLVALAFTPF 872
Query: 1245 LYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNME-----NRVILLVTS 1081
+ +A Y + + + E + A+E + N+RTV +L E N + +L+ +
Sbjct: 873 ILIAFYMQRTLMAKENMRPAKTMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGMLIPA 932
Query: 1080 HLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLS 901
RN++F+ G G A S FF YA +GTW V+ IL D + V +
Sbjct: 933 VEISKRNTHFR-----GLVYGLARSLMFFAYAACMYYGTWCVIHRGILFGDVFKVSQAVI 987
Query: 900 MTASYAGSAVAYLPDHRKAIHAAGLIF-HLFTYPAIMPYDSSQGKRNIKNGEIELKNVSF 724
M + +A+A+ P+ +K + AA IF L P+I+ G + V F
Sbjct: 988 MGTASIANALAFAPNMQKGVSAAKTIFTFLRRQPSIVDRPGVSRDPWHSEGYVRFDKVKF 1047
Query: 723 EYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVV 544
Y RS+ +L G+ L + G+ +ALVGPSG GKST I L++RFY +G IDE +V
Sbjct: 1048 SYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVR 1107
Query: 543 DVNLHHLRESVSLVSQEPVLFNCSIKENFLFG-ISHNASQLEIDQALKVANAFSFVSQFP 367
+V++ +LR + +VSQEP+LF+ +I+EN +G + N + EI A K +N F++ P
Sbjct: 1108 NVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARNVTDQEIISACKKSNIHEFIANLP 1167
Query: 366 QGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTAS 187
G DT +GE+GAQLSGGQKQRIAIARA++RNPK++LLDEATSALD++SEKVVQ+ALD AS
Sbjct: 1168 LGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESEKVVQDALDAAS 1227
Query: 186 ERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
E +T+ +AHRLSTVV++D I V +NG V E G H++LL R +Y+ L + Q
Sbjct: 1228 EGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLLANRGLYYTLYKLQ 1279
>gi|1079107|pir||A47377 multidrug resistance protein Mdr50 - fruit fly
(Drosophila melanogaster)
Length = 1283
Score = 680 bits (1755), Expect = 0.0
Identities = 422/1252 (33%), Positives = 683/1252 (53%), Gaps = 26/1252 (2%)
Frame = -1
Query: 3708 LKKTFGFQI-KCTTRYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKT 3532
+K+ FQ+ + T+ ++ L+ +G++ ++ TG+ P S G + ++ ++ + +
Sbjct: 41 VKQVSYFQLFRYATKKDRALYVIGLLSAVGTGLTTPANSLIFGNLANDMIDLSGLLESGK 100
Query: 3531 IDPVDLAHAYKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISR 3352
D A + L + + + L +G +L + + + +R ++
Sbjct: 101 SYRADDAISTLLLDK-VRQFSLQNTYIGMIMLVCSYLSITCFNYAAHSQILTIRSKFFRS 159
Query: 3351 LLRKDISYFDGMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRL 3172
+L +D+ ++D +G ++ +N+++ + + EK+ + + L FV +LAF W+L
Sbjct: 160 ILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQL 219
Query: 3171 ACYG-TVFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQE 2995
+ T + GL+ + + +K+ + A +A AL +TV + G+ +E
Sbjct: 220 SLVCLTSLPLTFIAMGLV-AVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKE 278
Query: 2994 VERYTEELKNGEKYALNRAFVFSLSRSADYFFTNALNFVILY-FGANMIYEGTIE---PG 2827
V Y E + + + R + +FF ++ + + +G ++ E E G
Sbjct: 279 VAAYKERVVAAKILNIKRNMFSGIGFGLLWFFFIYASYALAFWYGVGLVIESAYENYDAG 338
Query: 2826 VVVRILYYILFGSYCLGEAILHISRLASA---IPLTVPIADILLDSDATADEFFSEEIKD 2656
++ + + ++ GS +G A +I A +P I + + + + E
Sbjct: 339 TMITVFFSVMMGSMNIGMAAPYIEAFGIAQGRLPKVFHIIEQIPEINPLMGRVKVNEPLT 398
Query: 2655 TFQGIISFKNVLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNI 2476
T I FK V F YPTRP+V +L +++ + G+ +ALVG SG GKST IQL+ +Y+
Sbjct: 399 T----IEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDP 454
Query: 2475 DSGRISIDGNDIYNINIKQLR-QAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALK 2299
+G + +G ++ +++I LR +GVV QEP+LF TSI ENIR+G+ DAT +EI A
Sbjct: 455 QAGNLLFNGTNLKDLDINWLRFLRIGVVGQEPILFATSIYENIRYGREDATREEIEAARA 514
Query: 2298 NANAFDFVCNFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNES 2119
ANA F+ P G T+VGERGAQLSGGQKQRIAI R L+R+P ILLLDEATSALD S
Sbjct: 515 AANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIRRALIRDPEILLLDEATSALDTAS 574
Query: 2118 EFIVQEALQKASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNL 1939
E VQ AL+K S GRTTI+VAHRLST+R A++I+V+ KGE+VE G H++L+ + Y NL
Sbjct: 575 EAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNL 634
Query: 1938 VQTQLMSTNYEKMNENEERVTRQSSHSDFPSNEISHQKIDQEDDYV-------KKLIAEI 1780
V TQL + ++ + + + D EI D+++D + KK + ++
Sbjct: 635 VTTQLGEDDGSVLSPTGD-IYKNFDIKDEDEEEIKVLSEDEDEDVMVTDEKNKKKKMKKV 693
Query: 1779 KEEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAF-DKDEM 1603
K+ K + E++K + E+ + + + S I G P+ + L + + D D+
Sbjct: 694 KDPNEVKP-MLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGSILQILSVKDNDQY 752
Query: 1602 L-SKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDP 1426
+ S+ ++L L I F Q YFFG E+L+ +LR + F+ ++ A++DD
Sbjct: 753 VRENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDK 812
Query: 1425 CHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPL 1246
+ L RL+ D++ V A R+G++I ++ + L + +S +Y W + L L F P
Sbjct: 813 ANGTGSLCARLSGDAAAVQGATGQRIGTIIQSISTLALGIALSMYYEWSLGLVALAFTPF 872
Query: 1245 LYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNME-----NRVILLVTS 1081
+ +A Y + + + E + A+E + N+RTV +L E N + +L+ +
Sbjct: 873 ILIAFYMQRTLMAKENMRPAKTMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGMLIPA 932
Query: 1080 HLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLS 901
RN++F+ G G A S FF YA +GTW V+ IL D + V +
Sbjct: 933 VEISKRNTHFR-----GLVYGLARSLMFFAYAACMYYGTWCVIHRGILFGDVFKVSQAVI 987
Query: 900 MTASYAGSAVAYLPDHRKAIHAAGLIF-HLFTYPAIMPYDSSQGKRNIKNGEIELKNVSF 724
M + +A+A+ P+ +K + AA IF L P+I+ G + V F
Sbjct: 988 MGTASIANALAFAPNMQKGVSAAKTIFTFLRRQPSIVDRPGVSRDPWHSEGYVRFDKVKF 1047
Query: 723 EYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVV 544
Y RS+ +L G+ L + G+ +ALVGPSG GKST I L++RFY +G IDE +V
Sbjct: 1048 SYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVR 1107
Query: 543 DVNLHHLRESVSLVSQEPVLFNCSIKENFLFG-ISHNASQLEIDQALKVANAFSFVSQFP 367
+V++ +LR + +VSQEP+LF+ +I+EN +G + N + EI A K +N F++ P
Sbjct: 1108 NVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARNVTDQEIISACKKSNIHEFIANLP 1167
Query: 366 QGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTAS 187
G DT +GE+GAQLSGGQKQRIAIARA++RNPK++LLDEATSALD++SEKVVQ+ALD AS
Sbjct: 1168 LGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESEKVVQDALDAAS 1227
Query: 186 ERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
E +T+ +AHRLSTVV++D I V +NG V E G H++LL R +Y+ L + Q
Sbjct: 1228 EGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLLANRGLYYTLYKLQ 1279
>gi|39587992|emb|CAE57223.1| Hypothetical protein CBG00086
[Caenorhabditis briggsae]
Length = 1316
Score = 679 bits (1751), Expect = 0.0
Identities = 431/1258 (34%), Positives = 675/1258 (53%), Gaps = 43/1258 (3%)
Frame = -1
Query: 3669 RYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFE 3490
R + ++ +G++ S L+G+ QP G + L+ V N + + +D
Sbjct: 87 RRDHIILLIGILLSFLSGVAQPGLGVIAGGMTNTLI-VYNVTSPQFLD-----------S 134
Query: 3489 SDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMST 3310
+ MN V LF +G F+Q+ + V +R +YI +LR++ +FD +
Sbjct: 135 ALMN--VYLFGGIGVVVLIINFIQYMCFQNVCIRIVTKLREEYIKSILRQNAGWFDKNHS 192
Query: 3309 GHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLS 3130
G L+ L+DNMER E +K+ ++I + F G +++ + +WRLA +
Sbjct: 193 GTLTTKLHDNMERIHEGIGDKLGVLIRGIVMFGTGIVISLFYEWRLALMMMGIGPLCCIC 252
Query: 3129 GLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYA 2950
L S K+ + AGSIA ++L +TV + NGQ++ V RYT EL G+ YA
Sbjct: 253 MSLMSRSMSSYTSKELADVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYTAELGKGKSYA 312
Query: 2949 LNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTI-------EPGVVVRILYYILFG 2791
+ + +F L + YFG + Y G + PG V +++ +L G
Sbjct: 313 VKKGLW------GGFFGGIFLLILFTYFGGGIFYGGQLLRWKIIENPGDVFIVVFSMLIG 366
Query: 2790 SYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFS 2614
+Y LG H+ L +A I +++ D D + +E K D G + F+NV F
Sbjct: 367 AYFLGLISPHLMVLLNARVAAATIYEVI-DRVPEIDAYSNEGQKIDKIVGRVVFENVHFR 425
Query: 2613 YPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYN 2434
YPTR VL ++ ++ G +ALVG SG GKST + LL Y + G++ IDG+++ N
Sbjct: 426 YPTRKKAKVLNGLNLTIEPGTSVALVGHSGCGKSTSVGLLTRLYEQEDGKVMIDGHEVRN 485
Query: 2433 INIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGI 2254
+NI LR+ +G+V QEP+LF+ +I N+ G P+AT ++I K ANA +F+ P G
Sbjct: 486 LNIDWLRKVVGIVQQEPILFSGTIHNNLLIGNPNATRDDMIRVCKMANAHEFILKMPKGY 545
Query: 2253 KTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGR 2074
T++G+ G QLSGGQKQR+AIARTL+R+P++LLLDEATSALD +SE +VQ AL AS GR
Sbjct: 546 DTVIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESVVQSALNNASKGR 605
Query: 2073 TTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNE 1894
TTI++AHRLSTIR A+KI+ E G IVE G H +L+A+ G Y LV+ Q E ++
Sbjct: 606 TTIMIAHRLSTIREADKIVFFESGVIVESGTHDELVALGGRYAALVKAQQFKEADEVDDD 665
Query: 1893 NEERVT-RQSSHSDFPSNEISH----------------------------QKIDQEDDYV 1801
EE +T R S PS ++S+ Q + +D+
Sbjct: 666 VEEDITARIFSEKQMPSRQVSYHGSCVSLASADLEIGYASAFNSFNLKQAQDDIENEDFA 725
Query: 1800 KKLIAEIKEEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYA 1621
+++ ++E+G S +I K + Y L + + + ++G L+ ++ Y A
Sbjct: 726 EEVQRVMEEDGVITSGYYDIFKNAKGNYWYLSMGTVFAIMRG--SELALLAIMFGYVFEA 783
Query: 1620 FDKDEMLSKSHFWALSILFLAFTRPIFI--FFQYYFFGKTAEKLSIKLRSMSFKHLMSLP 1447
F+K + + IL+ +FI F AE L +K R SFK+L+
Sbjct: 784 FEKPDAEMARELVIIFILYGCLGLYVFITQVLSSTLFTIVAENLGLKFRVQSFKNLLYQD 843
Query: 1446 CAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKM--- 1276
+F+D+P H +L RL D+ NV A VD R+ VI ++ +I + ++ + W++
Sbjct: 844 ASFFDNPAHAPGKLITRLATDAPNVKAVVDTRMLQVIYSMTSITINLVTGYACCWQIAVV 903
Query: 1275 -SLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRV 1099
++ + +F L+ Y V I +++ + AIE +ENV+T++ L
Sbjct: 904 GTVMIALFALLMISMAY-----KIARVNLKQIKRDEAGKIAIEIVENVKTIQLLTSTEHF 958
Query: 1098 ILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYL 919
+ T+ L+ S K+A IQ N + + +F V + GT L+ + P +
Sbjct: 959 LTEYTTALELQHKSEMKKAYIQALNNAISQTFMYFAMFVCYAVGTPLMYNGIVDPNGAFR 1018
Query: 918 VLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIEL 739
+ ++ M + + P+ KA AAG++F L Y D +G + G I
Sbjct: 1019 AINSMMMGSVAVMHSSHNFPEFVKAKTAAGMLFKLI-YRKPKTGDVMKGNQLDIRGNILF 1077
Query: 738 KNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKID 559
++V F Y QR ++ + G+T+ALVGPSG+GKST I++LERFY G ++ID
Sbjct: 1078 ESVKFSYPQRPLHPVMTDLHFTARNGQTVALVGPSGTGKSTCIAMLERFYDVSGGALRID 1137
Query: 558 EENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFV 379
+++ ++LHHLR ++LV QEP LF +I+EN FG+ + +++QAL++ANA F+
Sbjct: 1138 GQDIKTLSLHHLRTQMALVGQEPRLFAGTIRENVCFGLKDVPIE-KVNQALELANASRFL 1196
Query: 378 SQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNAL 199
+ P G+DT VGE+G+QLSGGQKQRIAIARA++R+PK+LLLDEATSALDS+SE+V+Q AL
Sbjct: 1197 ANLPSGIDTEVGEKGSQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERVMQEAL 1256
Query: 198 DTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGI 25
D A E + + +AHRLS++ N+D I + GKV E G H L+ R Y+ L++KQ +
Sbjct: 1257 DRAREGRTCITIAHRLSSIQNSDLIVYIDQGKVQEAGNHNHLMSLRGKYYDLIKKQDL 1314
>gi|15217785|ref|NP_171753.1| multidrug resistance P-glycoprotein,
putative [Arabidopsis thaliana]
gi|25297455|pir||E86155 probable ABC transporter [imported] -
Arabidopsis thaliana
gi|9972378|gb|AAG10628.1| Putative ABC transporter [Arabidopsis
thaliana]
Length = 1278
Score = 679 bits (1751), Expect = 0.0
Identities = 426/1237 (34%), Positives = 663/1237 (53%), Gaps = 30/1237 (2%)
Frame = -1
Query: 3657 LLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFESDMN 3478
LL G + +I GM PF + G+ K N D VD+ ++
Sbjct: 56 LLMICGSIGAIGNGMSLPFMTLLFGDLIDSFGK-----NQNNKDIVDV----------VS 100
Query: 3477 RVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFD-GMSTGHL 3301
+V L F +G FLQ + G+ A +R Y+ +LR+DI +FD +TG +
Sbjct: 101 KVCLKFVYLGLGTLGAAFLQVACWMITGERQAARIRSTYLKTILRQDIGFFDVETNTGEV 160
Query: 3300 SIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLL 3121
++ + ++ EK+ I L++ FV G +LAF W L + ++G
Sbjct: 161 VGRMSGDTVLIQDAMGEKVGKFIQLVSTFVGGFVLAFIKGWLLTLVMLTSIPLLAMAGAA 220
Query: 3120 DSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNR 2941
+ + + + + A ++ Q +G +TV+S G++Q + Y + + + K ++ +
Sbjct: 221 MALIVTRASSRGQAAYAKAATVVEQTIGSIRTVASFTGEKQAINSYKKFITSAYKSSIQQ 280
Query: 2940 AFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEAILH 2761
F L +F + + ++FG MI E G V+ ++ ++ GS LG+
Sbjct: 281 GFSTGLGLGVMFFVFFSSYALAIWFGGKMILEKGYTGGAVINVIIIVVAGSMSLGQTSPC 340
Query: 2760 ISRLASAIPLTVPIADILLDSDATADEFFSEEIKDTFQGIISFKNVLFSYPTRPDVPVLK 2581
++ A+ + + + + ++ + +G I K+V FSYP RPD +
Sbjct: 341 VTAFAAGQAAAYKMFETIKRKPLIDAYDVNGKVLEDIRGDIELKDVHFSYPARPDEEIFD 400
Query: 2580 EISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAMG 2401
S + G ALVG SGSGKSTVI L+ +Y+ SG + IDG ++ +K +R +G
Sbjct: 401 GFSLFIPSGATAALVGESGSGKSTVISLIERFYDPKSGAVLIDGVNLKEFQLKWIRSKIG 460
Query: 2400 VVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGERGAQL 2221
+V QEPVLF++SI ENI +GK +AT +EI A + ANA F+ P G+ T+VGE G QL
Sbjct: 461 LVSQEPVLFSSSIMENIAYGKENATVEEIKAATELANAAKFIDKLPQGLDTMVGEHGTQL 520
Query: 2220 SGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHRLST 2041
SGGQKQRIAIAR ++++PRILLLDEATSALD ESE +VQEAL + + RTT++VAHRLST
Sbjct: 521 SGGQKQRIAIARAILKDPRILLLDEATSALDAESERVVQEALDRVMVNRTTVIVAHRLST 580
Query: 2040 IRNANKIIVMEKGEIVEVGDHKQLIA-MNGVYNNLVQTQ----------------LMSTN 1912
+RNA+ I V+ +G++VE G H +L+ G Y+ L++ Q ++N
Sbjct: 581 VRNADMIAVIHRGKMVEKGSHSELLKDSEGAYSQLIRLQEINKDVKTSELSSGSSFRNSN 640
Query: 1911 YEKMNENEERVTRQSSHSDFPSNEI-------SHQKIDQEDDYVKKLIAEIKEEGAKKSN 1753
+K E V S H + SH + +D+ +E K +
Sbjct: 641 LKKSMEGTSSVGNSSRHHSLNVLGLTTGLDLGSHSQRAGQDE-----TGTASQEPLPKVS 695
Query: 1752 ICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWALS 1573
+ I + E +L + + +AI G +PL L+ + EA+ E+ S FWA+
Sbjct: 696 LTRIAALNKPEIPVLLLGTVAAAINGAIFPLFGILISRVIEAFFKPAHELKRDSRFWAII 755
Query: 1572 ILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRL 1393
+ L T I Q Y F KL ++RSM F+ + + A++D+P +++ + RL
Sbjct: 756 FVALGVTSLIVSPTQMYLFAVAGGKLIRRIRSMCFEKAVHMEVAWFDEPQNSSGTMGARL 815
Query: 1392 NADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNF 1213
+AD++ + A V D L + + + +I++F SW+++L +L+ PL+ + G+ F
Sbjct: 816 SADATLIRALVGDALSLAVQNVASAASGLIIAFTASWELALIILVMLPLIGINGFVQVKF 875
Query: 1212 VDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQ 1033
+ + +E++++ A +A+ ++RTV + E +V+ + + K+ I
Sbjct: 876 MKGFSADAKSKYEEASQVANDAVGSIRTVASFCAEEKVMQMYKKQCEGPIKDGIKQGFIS 935
Query: 1032 GTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDH 853
G GF+ F +YA SF G LV + + + V L+M A + + PD
Sbjct: 936 GLGFGFSFFILFCVYATSFYAGARLVEDGKTTFNNVFQVFFALTMAAIGISQSSTFAPDS 995
Query: 852 RKAIHAAGLIFHLFTYPAIMPYDSSQGK--RNIKNGEIELKNVSFEYAQRSDKMILDGVS 679
KA AA IF + + + G N+K G+IEL+++SF Y R D I +
Sbjct: 996 SKAKVAAASIFAIIDRKSKIDSSDETGTVLENVK-GDIELRHLSFTYPARPDIQIFRDLC 1054
Query: 678 LKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVS 499
L + AG+T+ALVG SGSGKST+ISLL+RFY G + +D + + L LR+ + LV
Sbjct: 1055 LTIRAGKTVALVGESGSGKSTVISLLQRFYDPDSGHITLDGVELKKLQLKWLRQQMGLVG 1114
Query: 498 QEPVLFNCSIKENFLF--GISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQL 325
QEPVLFN +I+ N + G A++ EI A ++ANA F+S QG DT+VGERG QL
Sbjct: 1115 QEPVLFNDTIRANIAYGKGSEEAATESEIIAAAELANAHKFISSIQQGYDTVVGERGIQL 1174
Query: 324 SGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLST 145
SGGQKQR+AIARAI++ PK+LLLDEATSALD++SE+VVQ+ALD +T+VVAHRLST
Sbjct: 1175 SGGQKQRVAIARAIVKEPKILLLDEATSALDAESERVVQDALDRVMVNRTTIVVAHRLST 1234
Query: 144 VVNADSIAVLKNGKVAEQGTHEELLR-KRSIYWRLVQ 37
+ NAD IAV+KNG +AE+GTHE L++ + +Y LVQ
Sbjct: 1235 IKNADVIAVVKNGVIAEKGTHETLIKIEGGVYASLVQ 1271
>gi|31213429|ref|XP_315658.1| ENSANGP00000021663 [Anopheles gambiae]
gi|21299609|gb|EAA11754.1| ENSANGP00000021663 [Anopheles gambiae str.
PEST]
Length = 1243
Score = 677 bits (1748), Expect = 0.0
Identities = 420/1235 (34%), Positives = 669/1235 (54%), Gaps = 28/1235 (2%)
Frame = -1
Query: 3645 LGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKT--------------IDPVDLAH 3508
+GV+ + + + P+ GE + +LV T I T ++ + +
Sbjct: 14 MGVLLASMASLGLPYGVILYGEFTTLLVDRTIGIGKSTDTAILSIFGGGRVLVNATEQEN 73
Query: 3507 AYKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISY 3328
A + E D L V F F L ++ +R+ ++ +LR+D+++
Sbjct: 74 AAAIME-DAKAFGLGVVAVTILQFIFATLSVDVINRSAQKQISRIRQLFLKAVLRQDMTW 132
Query: 3327 FDGMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFS 3148
+D S ++ + D++++ +E EK+++ L+ FVI I +F+ W+L +
Sbjct: 133 YDLNSDDSFAVRITDDLDKLKEGIGEKLSIFTYLVMSFVISVIFSFFYGWKLTLVILSCA 192
Query: 3147 FGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELK 2968
I+L+ + + EK+ + S+AG++A + LG +TV + G+++E +RY E L
Sbjct: 193 PIIILATAFVAKMQSTLTEKELKSYSSAGAVAEEVLGSIRTVVAFGGEKKEADRYRERLA 252
Query: 2967 NGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIE------PGVVVRILY 2806
E + + +F + ++G ++I E + P V++ +L+
Sbjct: 253 GAELNGRRKGLFSGIGGGIMWFIIYCCYALAFWYGISLILEDRDKDLKDYTPAVLIIVLF 312
Query: 2805 YILFGSYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIKD-TFQGIISFK 2629
+L G+ LG + H+ ++A I ++ D D ++ + QG I F
Sbjct: 313 GVLAGAQNLGLSSPHLEAFSTAKGSAATIFSVI-DRIPVIDSLGDAGLRPGSMQGNIKFS 371
Query: 2628 NVLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDG 2449
NV F YP R DV VL+ ++ ++ G+ +ALVG SG GKST +QL+ Y+ SG ++IDG
Sbjct: 372 NVFFRYPARNDVQVLQGLNLEIKTGQTVALVGPSGCGKSTCLQLIQRLYDPLSGSVTIDG 431
Query: 2448 NDIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCN 2269
+ +NI LR +G+V QEPVLF T+I ENIR+G PDA++ EI A K AN F+
Sbjct: 432 TKVSELNIGWLRSFIGLVGQEPVLFATTIAENIRYGNPDASQSEIERAAKIANCHSFITK 491
Query: 2268 FPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQK 2089
P+G T++GERGAQLSGGQKQRIAIAR LVRNP+ILLLDEATSALD SE VQ+AL++
Sbjct: 492 LPNGYATMIGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDPNSEKRVQDALER 551
Query: 2088 ASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNY 1909
AS GRTT+VV+HRLSTI NA+KI+ ++KG ++E G H++L+A G+Y +LV +++
Sbjct: 552 ASKGRTTLVVSHRLSTITNADKIVYIDKGLVMEQGTHEELMAARGLYYDLV----VASGS 607
Query: 1908 EKMNENEERVTRQSSHSDFPSNEI---SHQKIDQEDDYVKKLIAEIKEEGAKKSNICEII 1738
+K +++E V S + + D+ D E ++E ++ ++
Sbjct: 608 QKTVDDDESVPMAPSALSMRQESVDDGAEASDDESDSGKSDEKNEEEQEEVYHVSLMRLL 667
Query: 1737 KYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAF-DKDEMLSKSHFWALSILFL 1561
K E+ + + + G +P + L + Y + D + + +S+F++ L L
Sbjct: 668 KLNAPEWHYILFGCAAAIVVGASFPAFAVLFGEMYGILSVADPEYVKEESNFYSFLFLVL 727
Query: 1560 AFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADS 1381
+ FFQ Y F +L+ +LR SFK ++S A++D+ + L RL+ D
Sbjct: 728 GLITGVGTFFQTYLFNIAGVRLTSRLRQKSFKAIVSQDMAWFDESRNAVGALCARLSGDC 787
Query: 1380 SNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQA 1201
++V A R+GS++ I + V +SFFYSW ++L ++ P+ + + +
Sbjct: 788 ASVQGATGTRIGSLLQAASTICIGVGISFFYSWNLTLVSIIAIPVTLASITLESRYSQTS 847
Query: 1200 VEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTAN 1021
++ + E + + A+EA+ N+RTV +L E V+ KI ++ ++ ++GT
Sbjct: 848 SLKEKQSQEGATKLAVEAISNIRTVASLGQEKHVLQRYGEETVKIDDACRRKTRLRGTVF 907
Query: 1020 GFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAI 841
F Y ++ +G LV +E+ D V L A G A+AY P+ AI
Sbjct: 908 ALGQVMPFAGYGLALFYGGKLVSEKELEYKDVIKVSEALIFGAWMLGQALAYAPNVNSAI 967
Query: 840 HAAGLIFHLFTYPAIM--PYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLP 667
+AG + L M P S G+I+ +V F Y R +L G++L +
Sbjct: 968 LSAGRLMKLLDRTPRMHNPSTSYHSLSQRTEGDIKFTDVEFRYPTRPTVPVLQGLNLDIG 1027
Query: 666 AGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPV 487
G+T+ALVGPSG GKST I LL R+Y G+V ID + +L+ +R + LVSQEP+
Sbjct: 1028 KGQTVALVGPSGCGKSTCIQLLLRYYDPDSGKVDIDGTTTTEFSLNRIRAQMGLVSQEPI 1087
Query: 486 LFNCSIKENFLFG-ISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQK 310
LF+ +I EN +G + + EI +A K+AN F+ P+G DT +G +GAQLSGGQK
Sbjct: 1088 LFDRTIAENIAYGDNTREIAMPEIMEAAKMANIHEFIVNLPKGYDTSLGSKGAQLSGGQK 1147
Query: 309 QRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNAD 130
QRIAIARA++RNP+VLLLDEATSALD+ SEK+VQNALD A + +++AHRL+T+ NA+
Sbjct: 1148 QRIAIARALVRNPRVLLLDEATSALDNQSEKIVQNALDHARTGRTCIIIAHRLTTIQNAN 1207
Query: 129 SIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGI 25
I V++NG V E GTH+EL+ K IY +L Q Q +
Sbjct: 1208 LICVIQNGVVVEAGTHDELMAKSRIYAKLYQMQQV 1242
Score = 315 bits (807), Expect = 5e-84
Identities = 188/528 (35%), Positives = 292/528 (54%), Gaps = 7/528 (1%)
Frame = -1
Query: 1584 WALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRL 1405
+ L ++ + + IF ++A+K ++R + K ++ +YD ++
Sbjct: 84 FGLGVVAVTILQFIFATLSVDVINRSAQKQISRIRQLFLKAVLRQDMTWYD--LNSDDSF 141
Query: 1404 SNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYC 1225
+ R+ D + + ++L +++ +++VI SFFY WK++L +L P++ LA
Sbjct: 142 AVRITDDLDKLKEGIGEKLSIFTYLVMSFVISVIFSFFYGWKLTLVILSCAPIIILATAF 201
Query: 1224 NDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKR 1045
E++ ++ + A E L ++RTV A E + L + ++
Sbjct: 202 VAKMQSTLTEKELKSYSSAGAVAEEVLGSIRTVVAFGGEKKEADRYRERLAGAELNGRRK 261
Query: 1044 AVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTY------LVLMTLSMTASYA 883
+ G G + YA++F +G L+L + + Y +VL + A
Sbjct: 262 GLFSGIGGGIMWFIIYCCYALAFWYGISLILEDRDKDLKDYTPAVLIIVLFGVLAGAQNL 321
Query: 882 GSAVAYLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGKR-NIKNGEIELKNVSFEYAQRS 706
G + +L A +A IF + ++ G R G I+ NV F Y R+
Sbjct: 322 GLSSPHLEAFSTAKGSAATIFSVIDRIPVIDSLGDAGLRPGSMQGNIKFSNVFFRYPARN 381
Query: 705 DKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHH 526
D +L G++L++ G+T+ALVGPSG GKST + L++R Y + G V ID V ++N+
Sbjct: 382 DVQVLQGLNLEIKTGQTVALVGPSGCGKSTCLQLIQRLYDPLSGSVTIDGTKVSELNIGW 441
Query: 525 LRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLV 346
LR + LV QEPVLF +I EN +G + +ASQ EI++A K+AN SF+++ P G T++
Sbjct: 442 LRSFIGLVGQEPVLFATTIAENIRYG-NPDASQSEIERAAKIANCHSFITKLPNGYATMI 500
Query: 345 GERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVV 166
GERGAQLSGGQKQRIAIARA++RNPK+LLLDEATSALD +SEK VQ+AL+ AS+ +T+V
Sbjct: 501 GERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDPNSEKRVQDALERASKGRTTLV 560
Query: 165 VAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQ 22
V+HRLST+ NAD I + G V EQGTHEEL+ R +Y+ LV G Q
Sbjct: 561 VSHRLSTITNADKIVYIDKGLVMEQGTHEELMAARGLYYDLVVASGSQ 608
>gi|15234322|ref|NP_192091.1| multidrug resistance P-glycoprotein,
putative [Arabidopsis thaliana]
gi|25297452|pir||D85023 P-glycoprotein-like protein pgp3 [imported] -
Arabidopsis thaliana
gi|4558551|gb|AAD22644.1| P-glycoprotein-like protein [Arabidopsis
thaliana]
gi|7268566|emb|CAB80675.1| P-glycoprotein-like protein pgp3
[Arabidopsis thaliana]
Length = 1229
Score = 676 bits (1745), Expect = 0.0
Identities = 418/1177 (35%), Positives = 647/1177 (54%), Gaps = 12/1177 (1%)
Frame = -1
Query: 3531 IDPVDLAHAYKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISR 3352
ID + + K +++V L F +G FLQ + G+ A +R Y+
Sbjct: 50 IDSIGQNQSNKDIVEIVSKVCLKFVYLGLGTLGAAFLQVACWMITGERQAARIRSLYLKT 109
Query: 3351 LLRKDISYFD-GMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWR 3175
+LR+DI +FD STG + ++ + E EK+ I L+ FV G +LAF W
Sbjct: 110 ILRQDIGFFDVETSTGEVVGRMSGDTVLILEAMGEKVGKFIQLIATFVGGFVLAFVKGWL 169
Query: 3174 LACYGTVFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQE 2995
L V + ++G + + ++ + A ++ Q LG +TV+S G++Q
Sbjct: 170 LTLVMLVSIPLLAIAGAAMPIIVTRASSREQAAYAKASTVVEQTLGSIRTVASFTGEKQA 229
Query: 2994 VERYTEELKNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVR 2815
++ Y E + + ++ + F L +F + ++FG MI + G VV
Sbjct: 230 MKSYREFINLAYRASVKQGFSMGLGLGVVFFVFFCSYALAIWFGGEMILKKGYTGGEVVN 289
Query: 2814 ILYYILFGSYCLGEAILHISRLASAIPLTVPIADILLDSDATADEF-FSEEIKDTFQGII 2638
++ ++ S LG+ ++ A+ + + + + + D F + ++ + +G I
Sbjct: 290 VMVTVVASSMSLGQTTPCLTAFAAGKAAAYKMFETI-ERKPSIDAFDLNGKVLEDIRGEI 348
Query: 2637 SFKNVLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRIS 2458
++V FSYP RP V S + G ALVG SGSGKS+VI L+ +Y+ SG +
Sbjct: 349 ELRDVCFSYPARPMEEVFGGFSLLIPSGATAALVGESGSGKSSVISLIERFYDPSSGSVL 408
Query: 2457 IDGNDIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDF 2278
IDG ++ +K +R +G+V QEPVLF++SI ENI +GK +AT +EI A K ANA +F
Sbjct: 409 IDGVNLKEFQLKWIRGKIGLVSQEPVLFSSSIMENIGYGKENATVEEIQAAAKLANAANF 468
Query: 2277 VCNFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEA 2098
+ P G++T+VGE G QLSGGQKQRIAIAR ++++PRILLLDEATSALD ESE +VQEA
Sbjct: 469 IDKLPRGLETLVGEHGTQLSGGQKQRIAIARAILKDPRILLLDEATSALDAESERVVQEA 528
Query: 2097 LQKASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIA-MNGVYNNLVQTQLM 1921
L + + RTT++VAHRLST+RNA+ I V+ +G+IVE G H +L+ G Y L++ Q +
Sbjct: 529 LDRVMMSRTTVIVAHRLSTVRNADMIAVIHRGKIVEEGSHSELLKDHEGAYAQLIRLQKI 588
Query: 1920 STNYEKMNENEERVTRQSSHSDFPSNEISHQKIDQEDDYVKKLI-----AEIKEEGAKKS 1756
+++ + E R S + S I + D + V L+ EI E ++
Sbjct: 589 KKEPKRLESSNE--LRDRSINRGSSRNIRTRVHDDDSVSVLGLLGRQENTEISREQSRNV 646
Query: 1755 NICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWAL 1576
+I I + E IL + L A+ G +P+ L K EA+ +M S FW++
Sbjct: 647 SITRIAALNKPETTILILGTLLGAVNGTIFPIFGILFAKVIEAFFKPPHDMKRDSRFWSM 706
Query: 1575 SILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNR 1396
+ L I Y F +L ++R M F+ ++ + ++DDP +++ + +R
Sbjct: 707 IFVLLGVASLIVYPMHTYLFAVAGGRLIQRIRVMCFEKVVHMEVGWFDDPENSSGTIGSR 766
Query: 1395 LNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDN 1216
L+AD++ + V D L + A + +I++F SWK+++ +L+ PL+ + GY
Sbjct: 767 LSADAALIKTLVGDSLSLSVKNAAAAVSGLIIAFTASWKLAVIILVMIPLIGINGYLQIK 826
Query: 1215 FVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVI 1036
F+ + +E++++ A +A+ ++RTV + E +V+ + + S K+ +I
Sbjct: 827 FIKGFTADAKAKYEEASQVANDAVGSIRTVASFCAEEKVMEMYKKRCEDTIKSGIKQGLI 886
Query: 1035 QGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPD 856
G G + + +YA F G LV D + V + L+MTA A ++ PD
Sbjct: 887 SGVGFGISFFVLYSVYASCFYVGARLVKAGRTNFNDVFQVFLALTMTAIGISQASSFAPD 946
Query: 855 HRKAIHAAGLIFHLFTYPAIMPYDSSQG--KRNIKNGEIELKNVSFEYAQRSDKMILDGV 682
KA AA IF + +++ G N+K G+IEL ++SF Y R D I +
Sbjct: 947 SSKAKGAAASIFGIIDGKSMIDSRDESGLVLENVK-GDIELCHISFTYQTRPDVQIFRDL 1005
Query: 681 SLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLV 502
+ AG+T+ALVG SGSGKST+ISLL+RFY G + +D + + L +R+ + LV
Sbjct: 1006 CFAIRAGQTVALVGESGSGKSTVISLLQRFYDPDSGHITLDRVELKKLQLKWVRQQMGLV 1065
Query: 501 SQEPVLFNCSIKENFLFGI-SHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQL 325
QEPVLFN +I+ N +G AS+ EI A ++ANA F+S QG DT+VGERG QL
Sbjct: 1066 GQEPVLFNDTIRSNIAYGKGGDEASEAEIIAAAELANAHGFISSIQQGYDTVVGERGIQL 1125
Query: 324 SGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLST 145
SGGQKQR+AIARAI++ PK+LLLDEATSALD++SE+VVQ+ALD +TVVVAHRLST
Sbjct: 1126 SGGQKQRVAIARAIVKEPKILLLDEATSALDAESERVVQDALDRVMVNRTTVVVAHRLST 1185
Query: 144 VVNADSIAVLKNGKVAEQGTHEELLR-KRSIYWRLVQ 37
+ NAD IAV+KNG + E+GTHE L+ + +Y LVQ
Sbjct: 1186 IKNADVIAVVKNGVIVEKGTHETLINIEGGVYASLVQ 1222
>gi|25455873|pir||T52319 P-glycoprotein-like protein pgp3 [imported] -
Arabidopsis thaliana
gi|2739309|emb|CAA75922.1| P-glycoprotein-like protein [Arabidopsis
thaliana]
Length = 1229
Score = 675 bits (1742), Expect = 0.0
Identities = 417/1177 (35%), Positives = 647/1177 (54%), Gaps = 12/1177 (1%)
Frame = -1
Query: 3531 IDPVDLAHAYKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISR 3352
ID + + K +++V L F +G FL+ + G+ A +R Y+
Sbjct: 50 IDSIGQNQSNKDIVEIVSKVCLKFVYLGLGTLGAAFLEVACWMITGERQAARIRSLYLKT 109
Query: 3351 LLRKDISYFD-GMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWR 3175
+LR+DI +FD STG + ++ + E EK+ I L+ FV G +LAF W
Sbjct: 110 ILRQDIGFFDVETSTGEVVGRMSGDTVLILEAMGEKVGKFIQLIATFVGGFVLAFVKGWL 169
Query: 3174 LACYGTVFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQE 2995
L V + ++G + + ++ + A ++ Q LG +TV+S G++Q
Sbjct: 170 LTLVMLVSIPLLAIAGAAMPIIVTRASSREQAAYAKASTVVEQTLGSIRTVASFTGEKQA 229
Query: 2994 VERYTEELKNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVR 2815
++ Y E + + ++ + F L +F + ++FG MI + G VV
Sbjct: 230 MKSYREFINLAYRASVKQGFSMGLGLGVVFFVFFCSYALAIWFGGEMILKKGYTGGEVVN 289
Query: 2814 ILYYILFGSYCLGEAILHISRLASAIPLTVPIADILLDSDATADEF-FSEEIKDTFQGII 2638
++ ++ S LG+ ++ A+ + + + + + D F + ++ + +G I
Sbjct: 290 VMVTVVASSMSLGQTTPCLTAFAAGKAAAYKMFETI-ERKPSIDAFDLNGKVLEDIRGEI 348
Query: 2637 SFKNVLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRIS 2458
++V FSYP RP V S + G ALVG SGSGKS+VI L+ +Y+ SG +
Sbjct: 349 ELRDVCFSYPARPMEEVFGGFSLLIPSGATAALVGESGSGKSSVISLIERFYDPSSGSVL 408
Query: 2457 IDGNDIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDF 2278
IDG ++ +K +R +G+V QEPVLF++SI ENI +GK +AT +EI A K ANA +F
Sbjct: 409 IDGVNLKEFQLKWIRGKIGLVSQEPVLFSSSIMENIGYGKENATVEEIQAAAKLANAANF 468
Query: 2277 VCNFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEA 2098
+ P G++T+VGE G QLSGGQKQRIAIAR ++++PRILLLDEATSALD ESE +VQEA
Sbjct: 469 IDKLPRGLETLVGEHGTQLSGGQKQRIAIARAILKDPRILLLDEATSALDAESERVVQEA 528
Query: 2097 LQKASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIA-MNGVYNNLVQTQLM 1921
L + + RTT++VAHRLST+RNA+ I V+ +G+IVE G H +L+ G Y L++ Q +
Sbjct: 529 LDRVMMSRTTVIVAHRLSTVRNADMIAVIHRGKIVEEGSHSELLKDHEGAYAQLIRLQKI 588
Query: 1920 STNYEKMNENEERVTRQSSHSDFPSNEISHQKIDQEDDYVKKLI-----AEIKEEGAKKS 1756
+++ + E R S + S I + D + V L+ EI E ++
Sbjct: 589 KKEPKRLESSNE--LRDRSINRGSSRNIRTRVHDDDSVSVLGLLGRQENTEISREQSRNV 646
Query: 1755 NICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWAL 1576
+I I + E IL + L A+ G +P+ L K EA+ +M S FW++
Sbjct: 647 SITRIAALNKPETTILILGTLLGAVNGTIFPIFGILFAKVIEAFFKPPHDMKRDSRFWSM 706
Query: 1575 SILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNR 1396
+ L I Y F +L ++R M F+ ++ + ++DDP +++ + +R
Sbjct: 707 IFVLLGVASLIVYPMHTYLFAVAGGRLIQRIRVMCFEKVVHMEVGWFDDPENSSGTIGSR 766
Query: 1395 LNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDN 1216
L+AD++ + V D L + A + +I++F SWK+++ +L+ PL+ + GY
Sbjct: 767 LSADAALIKTLVGDSLSLSVKNAAAAVSGLIIAFTASWKLAVIILVMIPLIGINGYLQIK 826
Query: 1215 FVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVI 1036
F+ + +E++++ A +A+ ++RTV + E +V+ + + S K+ +I
Sbjct: 827 FIKGFTADAKAKYEEASQVANDAVGSIRTVASFCAEEKVMEMYKKRCEDTIKSGIKQGLI 886
Query: 1035 QGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPD 856
G G + + +YA F G LV D + V + L+MTA A ++ PD
Sbjct: 887 SGVGFGISFFVLYSVYASCFYVGARLVKAGRTNFNDVFQVFLALTMTAIGISQASSFAPD 946
Query: 855 HRKAIHAAGLIFHLFTYPAIMPYDSSQG--KRNIKNGEIELKNVSFEYAQRSDKMILDGV 682
KA AA IF + +++ G N+K G+IEL ++SF Y R D I +
Sbjct: 947 SSKAKGAAASIFGIIDGKSMIDSRDESGLVLENVK-GDIELCHISFTYQTRPDVQIFRDL 1005
Query: 681 SLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLV 502
+ AG+T+ALVG SGSGKST+ISLL+RFY G + +D + + L +R+ + LV
Sbjct: 1006 CFAIRAGQTVALVGESGSGKSTVISLLQRFYDPDSGHITLDRVELKKLQLKWVRQQMGLV 1065
Query: 501 SQEPVLFNCSIKENFLFGI-SHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQL 325
QEPVLFN +I+ N +G AS+ EI A ++ANA F+S QG DT+VGERG QL
Sbjct: 1066 GQEPVLFNDTIRSNIAYGKGGDEASEAEIIAAAELANAHGFISSIQQGYDTVVGERGIQL 1125
Query: 324 SGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLST 145
SGGQKQR+AIARAI++ PK+LLLDEATSALD++SE+VVQ+ALD +TVVVAHRLST
Sbjct: 1126 SGGQKQRVAIARAIVKEPKILLLDEATSALDAESERVVQDALDRVMVNRTTVVVAHRLST 1185
Query: 144 VVNADSIAVLKNGKVAEQGTHEELLR-KRSIYWRLVQ 37
+ NAD IAV+KNG + E+GTHE L+ + +Y LVQ
Sbjct: 1186 IKNADVIAVVKNGVIVEKGTHETLINIEGGVYASLVQ 1222
>gi|17567269|ref|NP_510128.1| P-GlycoProtein related (146.8 kD)
(pgp-14) [Caenorhabditis elegans]
gi|7499665|pir||T21268 hypothetical protein F22E10.3 - Caenorhabditis
elegans
gi|3876293|emb|CAA91801.1| Hypothetical protein F22E10.3
[Caenorhabditis elegans]
gi|40764042|gb|AAR89639.1| P-glycoprotein related (146.8 kD) (pgp-14)
[Caenorhabditis elegans]
Length = 1327
Score = 675 bits (1741), Expect = 0.0
Identities = 432/1259 (34%), Positives = 688/1259 (54%), Gaps = 42/1259 (3%)
Frame = -1
Query: 3669 RYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFE 3490
+++ LL F+G + +I++G+ QP + G +VTNA+ + K F
Sbjct: 99 KFDYLLLFIGTICAIISGVSQPILALVSG-------RVTNAL-------LVYPPTSKQFR 144
Query: 3489 SDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMST 3310
+ N V +F +G F+Q+ + +R +++ +LR++ +FD +
Sbjct: 145 NKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFDKNHS 204
Query: 3309 GHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACY--GTVFSFGIV 3136
G ++ LND+MER RE +K+ +++ + ++A+ +WRLA G + I
Sbjct: 205 GTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCIC 264
Query: 3135 LSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEK 2956
+S L K+ + AGSIA ++L +TV + NGQ++ V RY EL+ G K
Sbjct: 265 MSLLARQM--TSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRK 322
Query: 2955 YALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIE-PGVVVRILYYILFGSYCL 2779
+A+ + F +F+ + + +GA ++ G I PG V ++ +L G+Y L
Sbjct: 323 FAVWKGFWSGFFGGLFFFWLFSFLGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFL 382
Query: 2778 GEAILHISRLASAIPLTVPIADILLDSDATAD-EFFSEEIK--DTFQGIISFKNVLFSYP 2608
G H+ L +A V A I D + +S+ K G + F+NV F YP
Sbjct: 383 GLISPHMMVLLNA---RVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYP 439
Query: 2607 TRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNIN 2428
+R D +L ++ V+ G +ALVG SG GKST + LL Y ++G ++IDG D+ +N
Sbjct: 440 SRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELN 499
Query: 2427 IKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKT 2248
I+ LR +G+V QEP+LFN +I N+ G P +T + +I+ K ANA DF+ P G T
Sbjct: 500 IEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYDT 559
Query: 2247 IVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTT 2068
++G+ G QLSGGQKQR+AIARTL+R+P++LLLDEATSALD +SE IVQ AL AS GRTT
Sbjct: 560 LIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTT 619
Query: 2067 IVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNENE 1888
I++AHRLSTIR A+KI+ EKG IVE G+H++L+ + G Y +LV+ Q + E E E
Sbjct: 620 IMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKADPEATEEFE 679
Query: 1887 E---------RVTRQSS-----------------HSDFPSNEISHQKIDQEDDYVKKLIA 1786
E R +R+SS + F ++ S Q + + A
Sbjct: 680 EEEIDLDDTSRSSRRSSMTSARSGSEAFRRGNSLNDSFSGSKRSAQADAENSAFAANEAA 739
Query: 1785 EIKEEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDK-- 1612
+ E+G + +I K + Y +F+ + + I+G+ P + + +E + F
Sbjct: 740 IMAEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYG 799
Query: 1611 DEMLSKSHFWALSILFLAFTRPIFIFFQY---YFFGKTAEKLSIKLRSMSFKHLMSLPCA 1441
M+ H A++++ A F Q F +E LS++ R SF++L+ +
Sbjct: 800 GRMM---HRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDAS 856
Query: 1440 FYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKM----- 1276
++D+P H +L RL +D+ N+ A VD R+ VI L AI+ + ++F Y W++
Sbjct: 857 YFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVIYALAAIIANIAIAFIYCWQIGILGT 916
Query: 1275 SLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVI 1096
SL +L+ ++ LA + V+Q +D + R AIE +ENV+T++ L
Sbjct: 917 SLILLLAFVMIGLAYKISLMNVEQIQNDD------AGRIAIEIIENVKTIQLLTRCELFF 970
Query: 1095 LLVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLV 916
+ ++ + S K+ +I+ S +F+ ++ G ++ + + DT+
Sbjct: 971 DHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKG 1030
Query: 915 LMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELK 736
++ + + A ++ Y P+ KA AAG++F++ Y D +G R G I +
Sbjct: 1031 IIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNII-YRKPRTGDLMEGDRPEIRGNILFE 1089
Query: 735 NVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDE 556
NV F Y QR + I+ G+ G+T+ALVGPSGSGKST I +LERFY G ++ID
Sbjct: 1090 NVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDG 1149
Query: 555 ENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVS 376
+++ ++L HLR ++LV QEP LF +I+EN G+ + +I+QAL++ANA F++
Sbjct: 1150 QDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGLK-DVPLEKINQALELANANRFLA 1208
Query: 375 QFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALD 196
P G+DT VGE+G QLSGGQKQRIAIARA++R+PK+LLLDEATSALDS+SE+ VQ ALD
Sbjct: 1209 NLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALD 1268
Query: 195 TASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQV 19
A E + + +AHRLS++ N+D I + GKV E G H +L+ ++ Y++L++KQ + V
Sbjct: 1269 RAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQDLAV 1327
Score = 293 bits (749), Expect = 3e-77
Identities = 205/644 (31%), Positives = 338/644 (51%), Gaps = 29/644 (4%)
Frame = -1
Query: 1860 SDFPSNEISHQKIDQEDD----YVKKLIAEI------------KEEGAKKSNICEIIKYC 1729
SD P+N + D +DD Y L+ +I ++ A+ +I + +Y
Sbjct: 43 SDLPANYV-----DDDDDAPKMYTPSLLEKILNYALCRGDIANQQLEAQPVSIPGLFRYG 97
Query: 1728 RS-EYCILFIAVLGSAIQGIYYP---LSSQLMIKSYEAYAFDKDEMLSKSHFWALSILFL 1561
+ +Y +LFI + + I G+ P L S + + Y + +K++ L +
Sbjct: 98 KKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKANENVYIFLGI 157
Query: 1560 AFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADS 1381
I F QY F ++ ++R ++ ++D H+ T ++ +LN
Sbjct: 158 GIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFDKN-HSGT-ITTKLNDSM 215
Query: 1380 SNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQA 1201
+ + D+LG ++ ++ A+++++ Y W+++ +L P + +
Sbjct: 216 ERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTST 275
Query: 1200 VEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTAN 1021
++ I K+ A E+L VRTV+A N + ++ + L+K R K AV +G +
Sbjct: 276 TIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGR----KFAVWKGFWS 331
Query: 1020 GFACSCYFF----IYAVSFKFGTWLVLREEIL--PMDTYLVLMTLSMTASYAGSAVAYLP 859
GF +FF +G +L L+ I+ P D ++V+M++ + A + G ++
Sbjct: 332 GFFGGLFFFWLFSFLGCGMLYGAYL-LKVGIITTPGDVFIVVMSMLLGAYFLGLISPHMM 390
Query: 858 DHRKA-IHAAGLIFHLFTYPAIMPYDSSQGKRNIKN--GEIELKNVSFEYAQRSDKMILD 688
A + AA + + P I PY S GKR ++N G ++ +NV F Y R D IL+
Sbjct: 391 VLLNARVSAASIYQTIDRVPKIDPY-SKAGKR-LQNVVGRVKFENVHFRYPSRKDAKILN 448
Query: 687 GVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVS 508
G++L + G ++ALVG SG GKST + LL R Y G V ID +V ++N+ LR +V
Sbjct: 449 GLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVG 508
Query: 507 LVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQ 328
+V QEP+LFN +I N L G + + I+ K+ANA F+ + P+G DTL+G+ G Q
Sbjct: 509 IVQQEPILFNDTIHNNLLIGNPGSTRETMIE-VCKMANAHDFIEKMPKGYDTLIGDGGVQ 567
Query: 327 LSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLS 148
LSGGQKQR+AIAR ++R+PKVLLLDEATSALD+ SE +VQ+AL+ AS+ +T+++AHRLS
Sbjct: 568 LSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLS 627
Query: 147 TVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQVE 16
T+ AD I + G + E G HEEL+R Y+ LV+ Q + +
Sbjct: 628 TIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKAD 671
>gi|19032275|dbj|BAB85651.1| multidrug resistance protein 1 homolog
[Triticum aestivum]
Length = 1262
Score = 674 bits (1740), Expect = 0.0
Identities = 422/1242 (33%), Positives = 667/1242 (52%), Gaps = 31/1242 (2%)
Frame = -1
Query: 3669 RYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFE 3490
R + LL +G + ++ G+ +P S G+ V N+ T V A
Sbjct: 39 RLDMLLMVVGSLGAVGNGVSEPLISVLFGD-------VINSFGESTTSTVLRA------- 84
Query: 3489 SDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDG-MS 3313
+ +VVL F +G FLQ + G+ + +R Y+ +LR+DI++FD M+
Sbjct: 85 --VTKVVLNFIYLGIGTAVASFLQVACWTMAGERQSARIRSLYLKSVLRQDIAFFDTEMT 142
Query: 3312 TGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVL 3133
TG ++ + ++ EK ++ L + F G I+AF W L + +
Sbjct: 143 TGEAVSRMSSDTVIIQDALGEKAGKLVQLTSAFFGGFIIAFTKGWLLTLVMLTSLPLVAI 202
Query: 3132 SGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKY 2953
+G + + + + K+ S+A + Q +G +TV S NG+++ +E Y + +K+ +
Sbjct: 203 AGAVSAQMLTRVSSKRLTSYSDAANTVEQTIGSIRTVVSFNGEKKAIEMYNKFIKSAYRT 262
Query: 2952 ALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGE 2773
+ V + + + + ++G +I + G +V +L+ +L G+ LG
Sbjct: 263 VVEEGLVNGFGMGSVFCILFSSYGLAFWYGGKLIIDKGYTGGKIVTVLFAVLNGATSLGN 322
Query: 2772 AILHISRLASAIPLTVPIADIL-----LDSDATADEFFSEEIKDTFQGIISFKNVLFSYP 2608
A IS +A + + + +DSD T S I + +G + K+V F YP
Sbjct: 323 ATPSISAIAEGQSAAYRLFETIERKPEIDSDDT-----SGMIMENIKGYVELKDVYFRYP 377
Query: 2607 TRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNIN 2428
R +L +S V G +A+VG SGSGKSTVI L+ +Y+ +G + IDG +I N+N
Sbjct: 378 ARLGQLILDGLSLQVASGTTMAIVGESGSGKSTVISLVERFYDPQAGEVLIDGVNIKNLN 437
Query: 2427 IKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKT 2248
+ +R +G+V QEP+LF TSI++NI +GK DAT +EI A + ANA +F+ P+G T
Sbjct: 438 LDWIRGKIGLVSQEPLLFMTSIKDNIIYGKEDATLEEIKRAAELANAANFIDKLPNGYDT 497
Query: 2247 IVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTT 2068
+VG+RG LSGGQKQRIAIAR ++++P+ILLLDEATSALD ESE IVQEAL + + RTT
Sbjct: 498 LVGQRGTLLSGGQKQRIAIARAILKDPKILLLDEATSALDVESERIVQEALNRIMVERTT 557
Query: 2067 IVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIA-MNGVYNNLVQTQLMSTNYEKMNEN 1891
+VVAHRLST+RN + I V+ +G+IVE G H L+ NG Y+ L++ Q + E+
Sbjct: 558 LVVAHRLSTVRNVDCITVVHQGKIVEQGTHHALVKDPNGAYSQLIRLQ-ETRGDERRKIQ 616
Query: 1890 EERVTRQSSHSDFPS--NEISHQKIDQEDDYVKK----LIAEIKEEGA------------ 1765
+ V S S S ++ + Y K L E+ E+
Sbjct: 617 DSGVPNSLSKSTSLSIRRSMTKDSFGNSNRYSFKNPLGLSVELHEDEITGEQNKDDLSNG 676
Query: 1764 ---KKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSK 1594
+K+ I + + E L + + +++ G+ +PL LM +A+ D++
Sbjct: 677 KTLQKAPIGRLFYLNKPEVPFLLLGAIAASVHGVIFPLFGILMSGVIKAFYEPPDKLRKD 736
Query: 1593 SHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTA 1414
S FWAL + L F I I +Y FG KL ++R++SF++++ A++D+P +++
Sbjct: 737 SSFWALISVVLGFASFIAIPAEYLLFGIAGGKLIERVRTLSFQNIVHQEVAWFDNPSNSS 796
Query: 1413 TRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLA 1234
L RL+ D+ NV V D LG ++ + A++ +++F W+++L + PL+
Sbjct: 797 GALGTRLSVDALNVRRLVGDNLGLIVQSTAALITGFVIAFTADWRLALIITCVIPLVGAQ 856
Query: 1233 GYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSY 1054
GY F+ EE +E +++ A +A+ ++RT+ + E RV+ + +R
Sbjct: 857 GYAQVKFLKGFSEEAKEMYEDASQVATDAVGSIRTIASFCAEKRVVTTYNKKCEALRKQG 916
Query: 1053 FKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSA 874
+ ++ G GF+ + YA+ F G V + + D + V L + A A
Sbjct: 917 IRSGIVGGLGFGFSFLVLYLTYALCFYVGAQFVRQGKTTFADVFKVFFALVLAAVGVSQA 976
Query: 873 VAYLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGK--RNIKNGEIELKNVSFEYAQRSDK 700
A + KA +A +F + + + + +G N+ G+I NVSF+Y R D
Sbjct: 977 SALASNATKARDSAISVFSILDRKSKIDTSNDEGLVLENV-TGDIHFSNVSFKYPSRPDV 1035
Query: 699 MILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLR 520
I +L +P+ +T+ALVG SGSGKSTII+LLERFY G + +D + + + LR
Sbjct: 1036 QIFSDFTLHIPSRKTIALVGESGSGKSTIIALLERFYDPDSGIISVDGVEIKSLRISWLR 1095
Query: 519 ESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGE 340
+ + LV QEPVLFN +I+ N +G ++ E+ K ANA F+S PQG DTLVGE
Sbjct: 1096 DQMGLVGQEPVLFNDTIRANITYGKHGEVTEEEVTAVAKAANAHEFISSLPQGYDTLVGE 1155
Query: 339 RGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVA 160
+G QLSGGQKQR+AIARAI+++PK+LLLDEATSALD++SE++VQ+ALD +T+VVA
Sbjct: 1156 KGVQLSGGQKQRVAIARAIIKDPKILLLDEATSALDAESERIVQDALDRVMVSRTTIVVA 1215
Query: 159 HRLSTVVNADSIAVLKNGKVAEQGTHEELLR-KRSIYWRLVQ 37
HRLST+ AD IAVLK GK+AE+G HE L+ K +Y LV+
Sbjct: 1216 HRLSTIKGADMIAVLKEGKIAEKGKHEALMGIKDGVYASLVE 1257
>gi|6472653|dbj|BAA87071.1| multi-drug resistance related mRNA [Felis
catus]
Length = 1163
Score = 673 bits (1737), Expect = 0.0
Identities = 405/1117 (36%), Positives = 615/1117 (54%), Gaps = 16/1117 (1%)
Frame = -1
Query: 3492 ESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMS 3313
E +M + +G ++Q S +R+Q+ ++R+++ +FD
Sbjct: 49 EEEMTTYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQILKIRKQFFHAIMRQEVGWFDVHD 108
Query: 3312 TGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVL 3133
G L+ L D++ + E +KI + + F IG I+ F W+L S + L
Sbjct: 109 VGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFIGFIVGFTRGWKLTLVILAISPVLGL 168
Query: 3132 SGLLDSWGKMKNNEKQNEHIS--NAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGE 2959
S + W K+ ++ E ++ AG++A + L +TV + GQ++E+ERY + L+ +
Sbjct: 169 SAAI--WAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAK 226
Query: 2958 KYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCL 2779
+ + +A ++S + A + ++G +++ G V+ + + +L G++ +
Sbjct: 227 RIGIKKAITANISIGIAFLLIYASYALAFWYGTSLVLSHEYSIGQVLTVFFSVLIGAFSV 286
Query: 2778 GEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPTR 2602
G+A I A+A I I+ D+ + D + K D +G + FKNV FSYP+R
Sbjct: 287 GQASPSIEAFANARGAAYEIFKII-DNKPSIDSYSKNGHKPDNIKGNLEFKNVHFSYPSR 345
Query: 2601 PDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIK 2422
+V +LK ++ VQ G+ +ALVG SG GKST +QL+ Y+ G +SIDG DI IN++
Sbjct: 346 KEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTDGMVSIDGQDIRTINVR 405
Query: 2421 QLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIV 2242
LR+ +GVV QEPVLF T+I ENIR+G+ + T +EI A+K ANA+DF+ P+ T+V
Sbjct: 406 YLREIIGVVSQEPVLFATTIAENIRYGRENVTMEEIEKAVKEANAYDFIMKLPNKFDTLV 465
Query: 2241 GERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIV 2062
GERGAQLSGGQKQRIAIAR LVRNP+ILLLDEATSALD+ESE +VQ AL KA GRTTIV
Sbjct: 466 GERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDSESEAVVQVALDKARKGRTTIV 525
Query: 2061 VAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLV-------QTQLMSTNYEK 1903
VAHRLSTIRNA+ I + G IVE G+H +L+ G+Y LV + +L + YE
Sbjct: 526 VAHRLSTIRNADVIAGFDDGVIVEKGNHDELMKEEGIYFKLVTMQTRGNEIELENAVYES 585
Query: 1902 MNENEE-RVTRQSSHSDFPSNEISHQKIDQEDDYVKKL-IAEIKEEGAKKSNICEIIKYC 1729
++E + ++ + S S + + I +KL E +E + I+K
Sbjct: 586 ISEIDALEMSPKDSGSSLIRRRSTRKSIHASQGQDRKLGTKENLDERVPPVSFWRILKLN 645
Query: 1728 RSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAY--AFDKDEMLSKSHFWALSILFLAF 1555
+E+ + + + I G P S ++ + + D + S+ ++L L L
Sbjct: 646 ITEWPYFVVGIFCAIINGGLQPAFSVILSRIIGVFTRVEDPETKRQNSNIFSLLFLVLGI 705
Query: 1554 TRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSN 1375
I F Q + FGK E L+ +LR M F+ ++ +++DDP +T L+ RL D++
Sbjct: 706 ISSITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQ 765
Query: 1374 VTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVE 1195
V A+ RL + + + +I+S Y W+++L +L P++ +AG +
Sbjct: 766 VKGAIGSRLAIITQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQAL 825
Query: 1194 EDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGF 1015
+D E + + A EA+EN RTV +L E + + LQ + ++A I G +
Sbjct: 826 KDKKELEGAGKVATEAIENFRTVVSLTREQKFEYMYAQSLQVPYRNSLRKAHIFGISFSI 885
Query: 1014 ACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKA-IH 838
+ +F YA F+FG +LV E + D LV + A G ++ PD+ KA +
Sbjct: 886 TQAMMYFSYAGCFRFGAYLVAHEFMDFQDVLLVFSAIVFGAMAVGQVSSFAPDYAKAKVS 945
Query: 837 AAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGR 658
AA +I + P I Y + N G + V F Y R D +L G+SL++ G+
Sbjct: 946 AAHVIMIIEKIPLIDSYSTEGLMPNTLEGNVTFNEVMFNYPTRPDIPVLQGLSLEVKKGQ 1005
Query: 657 TLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFN 478
TLALVG SG GKST++ LLERFY + G V ID + + +N+ LR + +VSQEP+LF+
Sbjct: 1006 TLALVGSSGCGKSTVVQLLERFYDPMAGTVLIDGKEIKHLNVQWLRAHMGIVSQEPILFD 1065
Query: 477 CSIKENFLFG-ISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRI 301
CSI EN +G S SQ EI +A K AN F+ P +T VG++G QLSGGQKQRI
Sbjct: 1066 CSIGENIAYGDNSRVVSQEEIVRAAKEANIHPFIETLPDKYNTRVGDKGTQLSGGQKQRI 1125
Query: 300 AIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTA 190
AIARA++R P++LLLDEATSALD++SEKVVQ ALD A
Sbjct: 1126 AIARALVRQPRILLLDEATSALDTESEKVVQEALDKA 1162
Score = 338 bits (866), Expect = 8e-91
Identities = 196/510 (38%), Positives = 296/510 (57%), Gaps = 3/510 (0%)
Frame = -1
Query: 1536 FFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVD 1357
+ Q F+ A + +K+R F +M ++D H L+ RL D S + +
Sbjct: 71 YIQVSFWCLAAGRQILKIRKQFFHAIMRQEVGWFD--VHDVGELNTRLTDDVSKINEGIG 128
Query: 1356 DRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAF 1177
D++G ++ + I+ F WK++L +L P+L L+ + +++ +A+
Sbjct: 129 DKIGMFFQSMATFFIGFIVGFTRGWKLTLVILAISPVLGLSAAIWAKILSSFTDKELLAY 188
Query: 1176 EKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYF 997
K+ A E L +RTV A + + + +L++ + K+A+ + G A +
Sbjct: 189 AKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGIAFLLIY 248
Query: 996 FIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFH 817
YA++F +GT LVL E V ++ + A G A + A AA IF
Sbjct: 249 ASYALAFWYGTSLVLSHEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFK 308
Query: 816 LF-TYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVG 640
+ P+I Y + K + G +E KNV F Y R + IL G++LK+ +G+T+ALVG
Sbjct: 309 IIDNKPSIDSYSKNGHKPDNIKGNLEFKNVHFSYPSRKEVKILKGLNLKVQSGQTVALVG 368
Query: 639 PSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKEN 460
SG GKST + L++R Y DG V ID +++ +N+ +LRE + +VSQEPVLF +I EN
Sbjct: 369 NSGCGKSTTVQLMQRLYDPTDGMVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAEN 428
Query: 459 FLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAIL 280
+G N + EI++A+K ANA+ F+ + P DTLVGERGAQLSGGQKQRIAIARA++
Sbjct: 429 IRYG-RENVTMEEIEKAVKEANAYDFIMKLPNKFDTLVGERGAQLSGGQKQRIAIARALV 487
Query: 279 RNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKV 100
RNPK+LLLDEATSALDS+SE VVQ ALD A + +T+VVAHRLST+ NAD IA +G +
Sbjct: 488 RNPKILLLDEATSALDSESEAVVQVALDKARKGRTTIVVAHRLSTIRNADVIAGFDDGVI 547
Query: 99 AEQGTHEELLRKRSIYWRLV--QKQGIQVE 16
E+G H+EL+++ IY++LV Q +G ++E
Sbjct: 548 VEKGNHDELMKEEGIYFKLVTMQTRGNEIE 577
>gi|15226477|ref|NP_182223.1| multidrug resistant (MDR) ABC
transporter, putative [Arabidopsis thaliana]
gi|7442647|pir||T02187 probable ABC transporter [imported] -
Arabidopsis thaliana
gi|3522943|gb|AAC34225.1| putative ABC transporter [Arabidopsis
thaliana]
Length = 1286
Score = 672 bits (1734), Expect = 0.0
Identities = 430/1250 (34%), Positives = 671/1250 (53%), Gaps = 40/1250 (3%)
Frame = -1
Query: 3666 YEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFES 3487
++ LL LG + SI G+ P + G+ L+ T D V
Sbjct: 58 FDFLLMILGTLGSIGNGLGFPLMTLLFGD----LIDAFGENQTNTTDKV----------- 102
Query: 3486 DMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFD-GMST 3310
++V L F +G F FLQ S G+ A +R Y+ +LR+DI++FD +T
Sbjct: 103 --SKVALKFVWLGIGTFAAAFLQLSGWMISGERQAARIRSLYLKTILRQDIAFFDIDTNT 160
Query: 3309 GHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLS 3130
G + ++ + ++ EK+ I LL FV G ++AF W L +V++
Sbjct: 161 GEVVGRMSGDTVLIQDAMGEKVGKAIQLLATFVGGFVIAFVRGWLLTLVMLSSIPLLVMA 220
Query: 3129 GLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYA 2950
G L + K + + A ++ Q +G +TV+S G++Q + Y + L K
Sbjct: 221 GALLAIVIAKTASRGQTAYAKAATVVEQTIGSIRTVASFTGEKQAISNYNKHLVTAYKAG 280
Query: 2949 LNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEA 2770
+ L + + +++G +I + G V+ I+ +L GS LG+
Sbjct: 281 VIEGGSTGLGLGTLFLVVFCSYALAVWYGGKLILDKGYTGGQVLNIIIAVLTGSMSLGQT 340
Query: 2769 ILHISRLASAIPLTVPIADIL-----LDSDATADEFFSEEIKDTFQGIISFKNVLFSYPT 2605
+S A+ + + + +DS +T + ++ D +G I K+V F+YP
Sbjct: 341 SPCLSAFAAGQAAAYKMFETIERRPNIDSYST-----NGKVLDDIKGDIELKDVYFTYPA 395
Query: 2604 RPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINI 2425
RPD + + S + G +ALVG SGSGKSTV+ L+ +Y+ +G + IDG ++ +
Sbjct: 396 RPDEQIFRGFSLFISSGTTVALVGQSGSGKSTVVSLIERFYDPQAGDVLIDGINLKEFQL 455
Query: 2424 KQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTI 2245
K +R +G+V QEPVLF SI++NI +GK DAT +EI A + ANA FV P G+ T+
Sbjct: 456 KWIRSKIGLVSQEPVLFTASIKDNIAYGKEDATTEEIKAAAELANASKFVDKLPQGLDTM 515
Query: 2244 VGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTI 2065
VGE G QLSGGQKQRIA+AR ++++PRILLLDEATSALD ESE +VQEAL + + RTT+
Sbjct: 516 VGEHGTQLSGGQKQRIAVARAILKDPRILLLDEATSALDAESERVVQEALDRIMVNRTTV 575
Query: 2064 VVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIA-MNGVYNNLVQTQLMSTNYEKMNENE 1888
VVAHRLST+RNA+ I V+ +G+IVE G H +L+ G Y+ L++ Q + E E +
Sbjct: 576 VVAHRLSTVRNADMIAVIHQGKIVEKGSHTELLKDPEGAYSQLIRLQEEKKSDENAAEEQ 635
Query: 1887 ERVT----RQSS----------------------HS----DFPSNEISHQKIDQEDDYVK 1798
+ + +QSS HS FP+ + DQE+D
Sbjct: 636 KMSSIESFKQSSLRKSSLGRSLSKGGSSRGNSSRHSFNMFGFPAGIDGNVVQDQEEDDTT 695
Query: 1797 KLIAEIKEEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAF 1618
+ E KK +I I + E +L + + +A G+ P+ L+ +A+
Sbjct: 696 QPKTE-----PKKVSIFRIAALNKPEIPVLILGSISAAANGVILPIFGILISSVIKAFFQ 750
Query: 1617 DKDEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAF 1438
++ + FWA+ + L F I Q +FF KL ++RSM F+ ++ + +
Sbjct: 751 PPKKLKEDTSFWAIIFMVLGFASIIAYPAQTFFFAIAGCKLVQRIRSMCFEKVVHMEVGW 810
Query: 1437 YDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLM 1258
+D+P +++ + RL+AD++ + V D L + L +IL +I++F W+++ VL
Sbjct: 811 FDEPENSSGTIGARLSADAATIRGLVGDSLAQTVQNLSSILAGLIIAFLACWQLAFVVLA 870
Query: 1257 FCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSH 1078
PL+ L G+ F+ + + ++++ A +A+ ++RTV + E++V+ + +
Sbjct: 871 MLPLIALNGFLYMKFMKGFSADAKKMYGEASQVANDAVGSIRTVASFCAEDKVMNMYSKK 930
Query: 1077 LQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSM 898
+ + ++ ++ G GF+ F YA SF G LV + + V L+M
Sbjct: 931 CEGPMKNGIRQGIVSGIGFGFSFFVLFSSYAASFYVGARLVDDGKTTFDSVFRVFFALTM 990
Query: 897 TASYAGSAVAYLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGK--RNIKNGEIELKNVSF 724
A + + PD KA AA IF + + + G+ N+K G+IEL++VSF
Sbjct: 991 AAMAISQSSSLSPDSSKADVAAASIFAIMDRESKIDPSVESGRVLDNVK-GDIELRHVSF 1049
Query: 723 EYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVV 544
+Y R D I + L + AG+T+ALVG SGSGKST+I+LL+RFY GE+ +D +
Sbjct: 1050 KYPARPDVQIFQDLCLSIRAGKTVALVGESGSGKSTVIALLQRFYDPDSGEITLDGVEIK 1109
Query: 543 DVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQ 364
+ L LR+ LVSQEP+LFN +I+ N +G +AS+ EI + +++NA F+S Q
Sbjct: 1110 SLRLKWLRQQTGLVSQEPILFNETIRANIAYGKGGDASESEIVSSAELSNAHGFISGLQQ 1169
Query: 363 GLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASE 184
G DT+VGERG QLSGGQKQR+AIARAI+++PKVLLLDEATSALD++SE+VVQ+ALD
Sbjct: 1170 GYDTMVGERGIQLSGGQKQRVAIARAIVKDPKVLLLDEATSALDAESERVVQDALDRVMV 1229
Query: 183 RLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLR-KRSIYWRLVQ 37
+T+VVAHRLST+ NAD IAV+KNG + E+G H+ L+ K +Y LVQ
Sbjct: 1230 NRTTIVVAHRLSTIKNADVIAVVKNGVIVEKGKHDTLINIKDGVYASLVQ 1279
>gi|27368855|emb|CAD59585.1| MDR-like ABC transporter [Oryza sativa
(japonica cultivar-group)]
Length = 1267
Score = 672 bits (1734), Expect = 0.0
Identities = 418/1232 (33%), Positives = 658/1232 (52%), Gaps = 33/1232 (2%)
Frame = -1
Query: 3663 EKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFESD 3484
+K L +G V ++ GM +P + V V + + V H
Sbjct: 43 DKALMAVGTVAAMANGMSEPLMTV-------VFSAVIDCFGGDDVSTV--LHR------- 86
Query: 3483 MNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFD-GMSTG 3307
+++VVL + +G FLQ S G+ + +R Y+ +L +DI++FD M+TG
Sbjct: 87 VSKVVLYYIYLGVGTSMASFLQVSCWTMAGERQSARIRSLYLEAILTQDIAFFDVEMTTG 146
Query: 3306 HLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACY------GTVFSF 3145
+ ++ + ++ EK+ I +LT FV G ++ F W LA ++FSF
Sbjct: 147 EAASRISADTVLIQDALGEKVGKYIQVLTAFVGGFVIGFIRGWMLALVVMACIPPSIFSF 206
Query: 3144 GIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKN 2965
+V S + + + K + S AG++ Q +G + V S NG+++ + Y +K
Sbjct: 207 ALV------SRLRAQISGKTHVSYSYAGNVVEQTIGSIRMVVSFNGEKRAITMYNTLIKK 260
Query: 2964 GEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSY 2785
K + + + +F + ++GA ++ G V+ +++ IL GS
Sbjct: 261 AYKATIMEGIISGFGIGSIFFVVYCSYSLAFWYGAKLVISKGYTGGQVINVVFAILTGSM 320
Query: 2784 CLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIKDTFQGIISFKNVLFSYPT 2605
+G A IS +A + +I+ S I + +G + K+V FSYP
Sbjct: 321 AIGNASPSISAIAEGQSAAHRLFEIINRKPNIDITGTSGIILEDIKGNVELKDVCFSYPA 380
Query: 2604 RPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINI 2425
RP+ +L + V G +A+VG SGSGKST+I L+ +Y+ G + IDG +I + +
Sbjct: 381 RPEQLILDGLCLQVPNGTTMAIVGQSGSGKSTIISLVERFYDPQDGEVLIDGINIKTLKL 440
Query: 2424 KQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTI 2245
+R M +V QEP+LF TSI++NI +GK +AT++EI A + ANA +F+ P+ T+
Sbjct: 441 HWIRGKMSLVSQEPLLFMTSIKDNITYGKENATDEEIKRAAELANAANFIDKLPNAYDTM 500
Query: 2244 VGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTI 2065
VG+ GAQLSGGQKQRIAIAR +++NP++LLLDEATSALD ESE +VQEAL + IGRTT+
Sbjct: 501 VGQHGAQLSGGQKQRIAIARAILKNPKVLLLDEATSALDVESERLVQEALNRVMIGRTTL 560
Query: 2064 VVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIA-MNGVYNNLVQTQLMSTNYEKMNE-- 1894
+VAHRLSTI+NA+ I V+ +G+IV+ G H +LI +G Y+ L+Q Q T+ E+M++
Sbjct: 561 IVAHRLSTIKNADCIAVVHQGKIVDQGSHDELIKDPDGAYSQLIQLQ--QTHTEEMHDVQ 618
Query: 1893 -NEERVTRQSSHS---------DFPSNE-----ISHQKIDQEDDYVKKLIAEIKEE---- 1771
+E +R S S D P N H D K + + E+
Sbjct: 619 YSEVSTSRLKSRSLSLEQSMINDSPRNRRKNSLAKHIGSSGSDGLHKHGLTDEPEDKECG 678
Query: 1770 ---GAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEML 1600
K+ I + + E IL +A++ + + G+ +P+ S +M + + ++
Sbjct: 679 DNKDINKAPIRRLFNLNKPEAPILLLAIITAFVHGLLFPIFSIMMSGGIRTFYYPPHQLR 738
Query: 1599 SKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCH 1420
S FWAL + +A + I +Y+ FG KL ++R +SF+ ++ +++DDP H
Sbjct: 739 KDSRFWALMCILMAIISLVSIQLEYFLFGMAGGKLIERVRCLSFQSIVHQEVSWFDDPSH 798
Query: 1419 TATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLY 1240
++ L +L D+ N+ V D L ++ +V ++ ++F WK++L ++ PL+
Sbjct: 799 SSGSLGAKLYIDALNIRRLVGDNLAILVQCIVTLIAGFTIAFASDWKLTLTIMCPIPLVG 858
Query: 1239 LAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRN 1060
L Y F+ E+ + +E +++ EA+ ++RTV + E RVI Q
Sbjct: 859 LQNYVQLKFLKGFSEDAKVMYEDASQVVTEAIGSIRTVASFCAEKRVIKTYNQKCQASMK 918
Query: 1059 SYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAG 880
+ ++ G F+ + YA+ F G V + D + V L TA
Sbjct: 919 ESIRSGMVGGLGFSFSYLMVYLTYALCFYVGAQFVHGGKSTFKDVFRVYFALVFTAFGIS 978
Query: 879 SAVAYLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGKRNIK-NGEIELKNVSFEYAQRSD 703
A D KA +A I + + + +G K NG IEL +V+F+Y R D
Sbjct: 979 QTSAMASDSSKAHESAASILAIIDRKSNIDSSIDEGIILEKVNGTIELNHVNFKYPSRPD 1038
Query: 702 KMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHL 523
+L +L +P+G+T+ALVG SGSGKST+I+LLERFY G + +D + ++ L L
Sbjct: 1039 VQVLCDFTLGIPSGKTVALVGESGSGKSTVIALLERFYDPHSGTISLDRVELKNLKLSWL 1098
Query: 522 RESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVG 343
R+ + LVSQEP+LFN +I N +G ++ EI K +NA F+S PQG +T VG
Sbjct: 1099 RDQMGLVSQEPILFNDTIHANIAYGRKGQVTEEEIIAVAKASNAHEFISSLPQGYNTTVG 1158
Query: 342 ERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVV 163
ERG QLSGGQKQRIAIARAIL++PK+LLLDEATSALD++SE++VQ+ALD +T+VV
Sbjct: 1159 ERGTQLSGGQKQRIAIARAILKDPKILLLDEATSALDAESERIVQDALDQVMVSRTTIVV 1218
Query: 162 AHRLSTVVNADSIAVLKNGKVAEQGTHEELLR 67
AHRLST+ AD IAV+K+G +AE+G H+ L+R
Sbjct: 1219 AHRLSTIKGADVIAVIKDGSIAEKGQHDSLMR 1250
Score = 295 bits (755), Expect = 6e-78
Identities = 184/512 (35%), Positives = 281/512 (53%), Gaps = 9/512 (1%)
Frame = -1
Query: 3423 LQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFD--GMSTGHLSIVLNDNMERFREVFNE 3250
L++ + G VR ++ +++S+FD S+G L L + R + +
Sbjct: 761 LEYFLFGMAGGKLIERVRCLSFQSIVHQEVSWFDDPSHSSGSLGAKLYIDALNIRRLVGD 820
Query: 3249 KIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLLDSWGKMKN----NEKQN 3082
+A+++ + + G +AF +DW+L I L GL ++ ++K +E
Sbjct: 821 NLAILVQCIVTLIAGFTIAFASDWKLTL---TIMCPIPLVGL-QNYVQLKFLKGFSEDAK 876
Query: 3081 EHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNRAFVFSLSRSADYF 2902
+A + +A+G +TV+S +++ ++ Y ++ + K ++ V L S Y
Sbjct: 877 VMYEDASQVVTEAIGSIRTVASFCAEKRVIKTYNQKCQASMKESIRSGMVGGLGFSFSYL 936
Query: 2901 FTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEAILHISRLASAIPLTVP 2722
+ Y GA ++ G V R+ + ++F ++ + + S + A
Sbjct: 937 MVYLTYALCFYVGAQFVHGGKSTFKDVFRVYFALVFTAFGISQTSAMASDSSKAHESAAS 996
Query: 2721 IADILLDSDATADEFFSEEI-KDTFQGIISFKNVLFSYPTRPDVPVLKEISFNVQGGECI 2545
I I+ D + D E I + G I +V F YP+RPDV VL + + + G+ +
Sbjct: 997 ILAII-DRKSNIDSSIDEGIILEKVNGTIELNHVNFKYPSRPDVQVLCDFTLGIPSGKTV 1055
Query: 2544 ALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAMGVVFQEPVLFNTS 2365
ALVG SGSGKSTVI LL +Y+ SG IS+D ++ N+ + LR MG+V QEP+LFN +
Sbjct: 1056 ALVGESGSGKSTVIALLERFYDPHSGTISLDRVELKNLKLSWLRDQMGLVSQEPILFNDT 1115
Query: 2364 IEENIRFG-KPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGERGAQLSGGQKQRIAIA 2188
I NI +G K TE+EII K +NA +F+ + P G T VGERG QLSGGQKQRIAIA
Sbjct: 1116 IHANIAYGRKGQVTEEEIIAVAKASNAHEFISSLPQGYNTTVGERGTQLSGGQKQRIAIA 1175
Query: 2187 RTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHRLSTIRNANKIIVME 2008
R ++++P+ILLLDEATSALD ESE IVQ+AL + + RTTIVVAHRLSTI+ A+ I V++
Sbjct: 1176 RAILKDPKILLLDEATSALDAESERIVQDALDQVMVSRTTIVVAHRLSTIKGADVIAVIK 1235
Query: 2007 KGEIVEVGDHKQLIAMN-GVYNNLVQTQLMST 1915
G I E G H L+ +N GVY +LV +T
Sbjct: 1236 DGSIAEKGQHDSLMRINGGVYASLVDLHSKTT 1267
>gi|27368859|emb|CAD59587.1| MDR-like ABC transporter [Oryza sativa
(japonica cultivar-group)]
Length = 1264
Score = 672 bits (1734), Expect = 0.0
Identities = 425/1242 (34%), Positives = 650/1242 (52%), Gaps = 31/1242 (2%)
Frame = -1
Query: 3669 RYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFE 3490
R + LL +G V ++ G+ QP + G V N+ T V
Sbjct: 42 RLDVLLMVVGTVGALGNGISQPLMTVLFGN-------VINSFGANTSGSV---------L 85
Query: 3489 SDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDG-MS 3313
+ +VVL F +G FLQ S G+ + +R Y+ +LR+DI++FD M+
Sbjct: 86 RSVTKVVLNFIYLGIGTSVASFLQVSCWTMAGERQSARIRSLYLKAVLRQDITFFDTEMT 145
Query: 3312 TGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVL 3133
TG ++ + + EK ++ LL+ F+ G I+AF W L I +
Sbjct: 146 TGEAVSRMSSDTLLIQGALGEKGGKLVELLSSFIGGFIIAFTRGWLLTLVMLTSLPLIAI 205
Query: 3132 SGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKY 2953
+ + + + + K+ S+AG Q +G +TV S NG+++ + Y +K K
Sbjct: 206 ASAVSAQALTRVSSKRQTSYSDAGDTVEQTIGSIRTVVSFNGEKKAIAMYRNFIKKSYKA 265
Query: 2952 ALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGE 2773
+ + + + ++G +I E G ++ IL+ +L G+ LG
Sbjct: 266 TIEEGIITGFGMGSVMCVVFGSYGLAFWYGGKLIIEKGYTGGKIMTILFAVLTGASSLGN 325
Query: 2772 AILHISRLASAIPLTVPIADILLDSDATADEFFSEEIKDTFQGIISFKNVLFSYPTRPDV 2593
A ++ + + + + + + + G I K+V F YP RP+
Sbjct: 326 ATPAVAAVVEGQSAAYNLFKTIERKPEIDSDDNNGMVLEDMNGDIELKDVYFRYPARPEQ 385
Query: 2592 PVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLR 2413
+L +S V G +A+VG SGSGKSTVI L+ +Y+ SG + IDG I + + +R
Sbjct: 386 LILDGLSLQVASGTTMAIVGESGSGKSTVISLVERFYDPQSGEVLIDGISIKKLRLDWIR 445
Query: 2412 QAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGER 2233
+G+V QEP+LF SI++NI +GK DAT +EI A + ANA +F+ P+G T+VG+R
Sbjct: 446 GKIGLVSQEPLLFMASIKDNIIYGKKDATLEEIKRAAELANAANFIDKLPNGYDTLVGQR 505
Query: 2232 GAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAH 2053
G QLSGGQKQRIAIAR ++++P+ILLLDEATSALD ESE IVQEAL + + RTT+VVAH
Sbjct: 506 GTQLSGGQKQRIAIARAILKDPKILLLDEATSALDVESERIVQEALNRMMVERTTLVVAH 565
Query: 2052 RLSTIRNANKIIVMEKGEIVEVGDHKQLIA-MNGVYNNLVQTQLMSTNYE-KMNENEERV 1879
RLST+RN + I V+ KG+IVE G H L+ +G Y+ L++ Q + K+ ++ +
Sbjct: 566 RLSTVRNVDCITVVRKGKIVEQGPHDALVKDPDGAYSQLIRLQETHRDERHKLPDSRSKS 625
Query: 1878 T----RQSSHSDF--PSNEIS-------------------HQKIDQEDDYVKKLIAEIKE 1774
T R+S DF SN S QK+D D+ K I
Sbjct: 626 TSLSFRRSRTKDFLSKSNRYSFKSPLGLPVDIHEDGMTSEQQKVDHSDNSDSKAI----- 680
Query: 1773 EGAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSK 1594
KK+ + + E +L + + +++ G+ PL +M +++ D++
Sbjct: 681 ---KKTPFGRLFNLNKPEVPVLLLGSIAASVHGVILPLYGIIMPGVLKSFYEPPDQLRKD 737
Query: 1593 SHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTA 1414
S FWAL + L I I +Y+ FG KL ++R++SF+ +M A++D P +++
Sbjct: 738 SRFWALMSVVLGVACLISIPAEYFLFGIAGGKLIQRVRTLSFQRIMHQEVAWFDKPSNSS 797
Query: 1413 TRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLA 1234
L RL+ D+ NV V D L ++ + ++ ++F W+++L + PL+
Sbjct: 798 GALGTRLSVDALNVRRLVGDNLALIVQAVATLITGFAIAFAADWRLALIITCVIPLVGAQ 857
Query: 1233 GYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSY 1054
GY F+ EE +E +N+ A +A+ ++RTV + E RV+ + + +R
Sbjct: 858 GYAQVKFLKGFSEESKEMYEDANQVAADAVGSIRTVASFCSEKRVVAIYNKKCEALRKQG 917
Query: 1053 FKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSA 874
+ ++ G F+ + Y + F G V + + D + V L + A +
Sbjct: 918 IRSGIVGGIGLSFSNLMLYLTYGLCFYVGAKFVSQGKTTFSDVFKVFFALVLAAVGVSQS 977
Query: 873 VAYLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGK--RNIKNGEIELKNVSFEYAQRSDK 700
A + KA +A IF + + + S +G N+ G I+ NVSF+Y R D
Sbjct: 978 SALSTNATKARDSAISIFSIIDRKSRIDSSSDEGAIMENV-TGSIDFNNVSFKYPSRPDV 1036
Query: 699 MILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLR 520
I +L +P+ +T+ALVG SGSGKSTII+LLERFY G + +D + + + LR
Sbjct: 1037 QIFSDFTLHIPSQKTIALVGESGSGKSTIIALLERFYDPDSGNISLDGVEIRSLKVSWLR 1096
Query: 519 ESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGE 340
+ + LV QEPVLFN +I+ N +G ++ EI K ANA FVS PQG DT+VGE
Sbjct: 1097 DQMGLVGQEPVLFNDTIRANITYGKHSEVTEEEITAVAKAANAHEFVSSLPQGYDTVVGE 1156
Query: 339 RGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVA 160
+G QLSGGQKQR+AIARAIL++PK+LLLDEATSALD++SE+VVQ+ALD +T+VVA
Sbjct: 1157 KGVQLSGGQKQRVAIARAILKDPKILLLDEATSALDAESERVVQDALDRVMVNRTTIVVA 1216
Query: 159 HRLSTVVNADSIAVLKNGKVAEQGTHEELLR-KRSIYWRLVQ 37
HRLST+ AD IAVLK GK+AE+G HE LLR K Y LVQ
Sbjct: 1217 HRLSTIKGADMIAVLKEGKIAEKGKHEALLRIKDGAYASLVQ 1258
>gi|34913530|ref|NP_918112.1| putative multidrug resistance protein
[Oryza sativa (japonica cultivar-group)]
gi|20146370|dbj|BAB89151.1| putative multidrug resistance protein
[Oryza sativa (japonica cultivar-group)]
gi|27368871|emb|CAD59593.1| MDR-like ABC transporter [Oryza sativa
(japonica cultivar-group)]
Length = 1287
Score = 669 bits (1726), Expect = 0.0
Identities = 431/1249 (34%), Positives = 656/1249 (52%), Gaps = 43/1249 (3%)
Frame = -1
Query: 3654 LFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFESDMNR 3475
L +G ++ GM QP ++ G+ V NA + T P LA K
Sbjct: 58 LMAVGAAAAVANGMAQPLMTFIFGD-------VINAFGS-TSSPDVLAKVTK-------- 101
Query: 3474 VVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDG-MSTGHLS 3298
V+L F +G LQ S G+ A +R Y+ +LR+DI++FD MSTG +
Sbjct: 102 VILNFVYLGIGAGFVSTLQVSCWTITGERQAARIRALYLKAILRQDIAFFDKEMSTGQVV 161
Query: 3297 IVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLLD 3118
++ + ++ EK I LL+ F G I+AF W LA I ++G
Sbjct: 162 ERMSGDTFLIQDAIGEKSGKCIQLLSTFFGGFIIAFVRGWLLALVLLSCIPPIAVAGAFV 221
Query: 3117 SWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNRA 2938
S + + + E +AG+IA Q +G +TV+S NG++Q + Y + ++ + L
Sbjct: 222 SRLMTRISTRMQEKYGDAGNIAEQTIGAIRTVASFNGEKQAINTYNKFIRKAYESTLQEG 281
Query: 2937 FVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEAILHI 2758
V L + +++G+ +I G+V+ +L ++ G+ LG+A I
Sbjct: 282 VVNGLGLGTVMAILFCSYGLAVWYGSKLIVNRGYNGGIVINVLMSVMMGAMSLGQATPSI 341
Query: 2757 SRLASAIPLTVPIADILL---DSDATADEFFSEEIKDTFQGIISFKNVLFSYPTRPDVPV 2587
+ A + + D D + I + G + K+V FSYPTRP+ V
Sbjct: 342 TAFAEGQGAAYRMFKTIKRQPDIDVCDTKGI---ILEDITGDVELKDVYFSYPTRPEYLV 398
Query: 2586 LKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQA 2407
S + G +ALVG SGSGKSTVI L+ +Y+ SG + IDG DI +N+ +R
Sbjct: 399 FNGFSLQIPSGRTMALVGESGSGKSTVISLVERFYDPQSGEVLIDGIDIRRMNLGWIRGK 458
Query: 2406 MGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGERGA 2227
+ +V QEPVLF+++I ENI +GK D T +EI A++ ANA FV P+G++T+VGERG
Sbjct: 459 ISLVSQEPVLFSSTIRENIAYGKEDQTLEEIKRAVELANAAKFVDKLPNGLETMVGERGI 518
Query: 2226 QLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHRL 2047
QLSGGQKQRIAIAR +++NPRILLLDEATSALD ESE +VQ+AL + + RTTI+VAHRL
Sbjct: 519 QLSGGQKQRIAIARAIIKNPRILLLDEATSALDMESERVVQDALNRVMLERTTIIVAHRL 578
Query: 2046 STIRNANKIIVMEKGEIVEVGDHKQLIAM-NGVYNNLVQTQLMSTNYEKMNENEERVTRQ 1870
ST++NA+ I V+++G++VE G H +L+ G Y L+Q Q + E N++ + + R
Sbjct: 579 STVKNADVISVLQQGKMVEQGSHVELMKKPEGAYAQLIQLQGAQQDAEIHNDDTDMIIRS 638
Query: 1869 SSHS------------------------------------DFPSNEISHQKIDQEDDYVK 1798
S S DFP ++ +DD
Sbjct: 639 DSGSRSINVKPRSQSTSFRRSITKGSSFGHSGRHPIPAPLDFPD------PMEFKDDLGM 692
Query: 1797 KLIAEIKEEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAF 1618
+ + G KK++I + + E +L + + +A+ G+ +P+ L+ + + +
Sbjct: 693 EETTDKVPRGQKKASISRLFYLNKPEAFVLVLGSVTAAMHGLMFPIFGILISSAIKMFYE 752
Query: 1617 DKDEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAF 1438
E+L S FWA + + + + I +Y+ FG KL ++RS++F+ +M +
Sbjct: 753 PPSELLKDSRFWASMFVVVGASAFVLIPTEYFLFGLAGGKLVERIRSLTFRSVMHQEINW 812
Query: 1437 YDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLM 1258
+D P H++ + RL+ D+ NV V D L + T+ ++ ++ +WK++L + +
Sbjct: 813 FDKPEHSSGSIGARLSVDALNVKRLVGDNLALNVQTVSTVISGFTIAMVANWKLALIITV 872
Query: 1257 FCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSH 1078
PL+ Y F+ + + +E++++ A +A+ +RTV + E +VI
Sbjct: 873 VVPLVGFQAYAQMKFLKGFNKNAKLKYEEASQVATDAVGGIRTVASFCAEQKVIEAYEKK 932
Query: 1077 LQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSM 898
+ + V+ G GF+ ++F YA+ F G V + + + V L +
Sbjct: 933 CESPVRQGIREGVVGGLGFGFSFLVFYFTYALCFYVGAKFVHQGVATFPEVFRVFFVLVL 992
Query: 897 TASYAGSAVAYLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGKRNIK-NGEIELKNVSFE 721
S A D KA +A IF + + + S +G G+IE NV F
Sbjct: 993 ATSGISRTSAIGADSTKANESAVSIFEILDRKSKIDSSSEEGVVIASVRGDIEFHNVCFN 1052
Query: 720 YAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVD 541
Y R + I +SL +P+G+T+ALVG SGSGKST I+LLERFY G++ +D ++
Sbjct: 1053 YPLRPNIQIFKDLSLCIPSGKTVALVGESGSGKSTAIALLERFYDPDTGKILLDGVDLKT 1112
Query: 540 VNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQG 361
+ LR + LV+QEPVLFN +I N +G ASQ EI A + ANA F+S P G
Sbjct: 1113 FKVSWLRIQIGLVAQEPVLFNDTIHANIAYGKQEQASQEEIMAAAEAANAHQFISALPDG 1172
Query: 360 LDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASER 181
T+VGERG QLSGGQKQR+AIARAI+++PKVLLLDEATSALD++SE+VVQ ALD
Sbjct: 1173 YSTVVGERGIQLSGGQKQRVAIARAIMKDPKVLLLDEATSALDAESERVVQEALDRVMVG 1232
Query: 180 LSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLR-KRSIYWRLVQ 37
+TVVVAHRLST+ AD I VLKNG + E+G H+EL+R K Y LV+
Sbjct: 1233 RTTVVVAHRLSTIKGADIIGVLKNGAIVEKGGHDELMRIKDGTYASLVE 1281
>gi|39587990|emb|CAE57221.1| Hypothetical protein CBG00083
[Caenorhabditis briggsae]
Length = 1301
Score = 669 bits (1726), Expect = 0.0
Identities = 430/1264 (34%), Positives = 686/1264 (54%), Gaps = 46/1264 (3%)
Frame = -1
Query: 3672 TRYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLF 3493
T ++ +L +GVV SI++G+ QP + G + VL+ +DP+ K
Sbjct: 64 TPFDYILLIIGVVTSIISGVSQPVLAIISGRLTNVLL---------VVDPLSKEFKNKAM 114
Query: 3492 ESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMS 3313
E+ V +F +G F Q+ + V +R +YIS +LR++ +FD
Sbjct: 115 EN-----VYIFLGLGIFVSINDFCQYMCFQRVCSRMMTQMRNRYISSILRQNAGWFDKNL 169
Query: 3312 TGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGT-VFSFGIV 3136
+G ++ LNDNMER ++ +K+ ++I ++ + I++ +WRLA + +
Sbjct: 170 SGTITTRLNDNMERIQDGVGDKLGVLIRGISMVLTSVIISLVYEWRLALMMVGLIPVSTI 229
Query: 3135 LSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEK 2956
LL + + K+ ++ E + AG+IA ++L +T+ + NGQ++ V +Y + L +G++
Sbjct: 230 CMTLLSRFLE-KSTGEELEKVGIAGAIAEESLMGVRTIQAFNGQEEMVAKYEKHLNSGKR 288
Query: 2955 YALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIE-PGVVVRILYYILFGSYCL 2779
+A+ F +F+ A + +G ++ G I+ PG V I+ +L G+Y L
Sbjct: 289 HAIIGGFWSGFFGGMFFFWLLAFMGCGILYGGYLLKVGIIKSPGDVFIIIMAMLLGAYFL 348
Query: 2778 GEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPTR 2602
G H+ L +A I + D D + K D G ++F+NV F YPTR
Sbjct: 349 GLISPHLMVLLNARVAAASIYKTI-DRVPKIDPYSKAGKKLDRVVGKVTFRNVHFRYPTR 407
Query: 2601 PDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIK 2422
+ VL + V+ G +ALVG SG GKST + LL Y + G + IDG D+ ++N+
Sbjct: 408 KEAKVLNGLDLTVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEDGSVQIDGVDVRDLNMD 467
Query: 2421 QLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIV 2242
LR +G+V QEP+LFN +I N+ G PDAT +++I+ K ANA DF+ P G T++
Sbjct: 468 WLRNIVGIVQQEPILFNDTIHNNLLIGNPDATREKMIEVCKMANAHDFIKKMPKGYDTLI 527
Query: 2241 GERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIV 2062
G+ G QLSGGQKQR+AIARTL+R+P+ILLLDEATSALD +SE +VQ AL A+ GRTTI+
Sbjct: 528 GDGGVQLSGGQKQRVAIARTLIRDPKILLLDEATSALDAQSESVVQSALNNAARGRTTIM 587
Query: 2061 VAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMN----- 1897
+AHRLSTIR A+KI+ EKG IVE G+H +L+A+ G Y NLV+ Q + E +
Sbjct: 588 IAHRLSTIREADKIVFFEKGVIVEAGNHGELVALGGRYYNLVKAQQFKQDPEDIELEAEQ 647
Query: 1896 -------ENEERVTRQ----------------------SSHSDFPSNEISHQKIDQEDDY 1804
E TRQ ++HS + SH +++ +
Sbjct: 648 EDQFDEFEKPTMFTRQVSTRSSRSSGRSGSDEFRRGTLANHSFDRFRKPSHVPTAEDEAF 707
Query: 1803 VKKLIAEIKEEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAY 1624
K+ ++++ + +I K Y +FI ++ + I+G+ P + L+ +E +
Sbjct: 708 ALKVKETMEKDEEVTAGYLDIFKNAHGNYGYMFIGLVAALIRGLDLPAFALLLSWVFEGF 767
Query: 1623 AFDK--DEMLSKSHFWALSILFLAFTRPIFIFFQ---YYFFGKTAEKLSIKLRSMSFKHL 1459
F +M+ H + +S++ FFQ F +E L ++ R +F++L
Sbjct: 768 EFVPYGGKMM---HRFVMSVIAHCGVGLGIWFFQTLSTVMFAIVSENLGVRFRVDAFRNL 824
Query: 1458 MSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWK 1279
+ A++D+P H L RL AD +V A VD R+ VI A++ V + F Y W+
Sbjct: 825 LYQDSAYFDNPAHAPGSLITRLAADPPSVKAVVDGRMMQVIYAFSAVVACVTIGFIYCWQ 884
Query: 1278 MSLQVLMFCPLLYLAGY--CNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMEN 1105
++ ++ L++ G+ C F + + + + + + AIE +ENV+T++ L
Sbjct: 885 VA---ILGTSLIFFLGFVMCGLAFKITILAVEHMQNDDAGKVAIEIIENVKTIQLLTRTK 941
Query: 1104 RVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWL-VLREEILPMD 928
R + + +K + + +++V + A ++ + F Y F F + V+ E P+D
Sbjct: 942 RFLNSYENESKKRKTTELRKSVFE--AINYSITQNFMYYMSCFCFALAIRVINEGDQPVD 999
Query: 927 -TYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGKRNIKNG 751
T+ LM + + + + P A AAG +F+L Y D G + G
Sbjct: 1000 KTFRSLMAMMLCCEGIILSAQFFPQFVGAKSAAGQMFNLI-YRKPQTGDVKTGSQPEIRG 1058
Query: 750 EIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGE 571
I +NV F Y QR + ++ + G+T+A+VGPSGSGKST IS+LERFY G
Sbjct: 1059 NILFENVKFSYPQRPHQPVMKTLQWTALRGQTVAIVGPSGSGKSTCISMLERFYDVTGGA 1118
Query: 570 VKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANA 391
++ID +++ ++L+HLR ++LV QEP LF +I+EN G+ + +I+QAL++ANA
Sbjct: 1119 LRIDGQDIRTMSLYHLRTQMALVGQEPRLFVGTIRENICLGLK-DVPLEKINQALELANA 1177
Query: 390 FSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVV 211
F+ P G+DT VGERG QLSGGQKQRIAIARA++R+PK+LLLDEATSALDS+SEK V
Sbjct: 1178 NRFLGNLPAGIDTEVGERGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESEKAV 1237
Query: 210 QNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
Q ALD A E + + +AHRLS++ N+D I + +G+V E GTH EL+ + Y+ L++KQ
Sbjct: 1238 QEALDRAREGRTCITIAHRLSSIQNSDLIVYIDDGRVQEAGTHNELMHMKGKYFELIKKQ 1297
Query: 30 GIQV 19
+ +
Sbjct: 1298 DLAI 1301
>gi|39587988|emb|CAE57219.1| Hypothetical protein CBG00079
[Caenorhabditis briggsae]
Length = 1327
Score = 668 bits (1723), Expect = 0.0
Identities = 423/1254 (33%), Positives = 685/1254 (53%), Gaps = 37/1254 (2%)
Frame = -1
Query: 3669 RYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFE 3490
R++ LL F+G + +I++G+ QP + G +VTNA+ + K F
Sbjct: 99 RFDYLLLFIGTICAIISGVSQPIMALVSG-------RVTNAL-------LVYPPTSKQFR 144
Query: 3489 SDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMST 3310
+ N V +F +G ++Q+ + +R +++ +LR++ +FD +
Sbjct: 145 NKANENVYIFLGIGIFISITNWIQYMCFQHCCSRVMAQMRHRFVYSVLRQNAGWFDKNHS 204
Query: 3309 GHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLS 3130
G ++ LND+MER RE +K+ +++ + ++A+ +WRLA + +
Sbjct: 205 GTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPVCCIC 264
Query: 3129 GLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYA 2950
L + K+ + AGSIA ++L +TV + NGQ++ V RY EL+ G ++A
Sbjct: 265 MSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYQTELEKGRRFA 324
Query: 2949 LNRAFVFSLSRSADYFFTNALNFVI--LYFGANMIYEGTI-EPGVVVRILYYILFGSYCL 2779
+ + F FF +F+ + +GA ++ G I PG V ++ +L G+Y L
Sbjct: 325 VWKGFWSGFF--GGLFFLCLFSFLGTGMLYGAYLLKVGIIGSPGDVFIVVMSMLLGAYFL 382
Query: 2778 GEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPTR 2602
G H+ L +A I + D D + + G + F+NV F YP+R
Sbjct: 383 GLISPHMMVLLNARVSAATIYQTI-DRVPKIDPYSKAGKRLPNVVGRVKFENVHFRYPSR 441
Query: 2601 PDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIK 2422
+ +L ++ V+ G +ALVG SG GKST + LL Y ++G ++IDG D+ +NI
Sbjct: 442 KEAKILNGLNLTVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNID 501
Query: 2421 QLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIV 2242
LR +G+V QEP+LFN +I N+ G P AT +++I+ K ANA DF+ P G T++
Sbjct: 502 WLRNVVGIVQQEPILFNDTIHNNLLIGNPGATREKMIEVCKMANAHDFIEKMPKGYDTLI 561
Query: 2241 GERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIV 2062
G+ G QLSGGQKQR+AIARTL+R+P+ILLLDEATSALD +SE +VQ AL A+ GRTTI+
Sbjct: 562 GDGGVQLSGGQKQRVAIARTLIRDPKILLLDEATSALDAQSESVVQSALNNAAKGRTTIM 621
Query: 2061 VAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNENEE- 1885
+AHRLSTIR A+KI+ EKG IVE G+H++L+ + G Y +LV+ Q + E E EE
Sbjct: 622 IAHRLSTIREADKIVFFEKGVIVEAGNHEELVHLGGRYFDLVKAQQFKADPEATEEFEEE 681
Query: 1884 --------RVTRQSSHSDFPSNEISHQ----------------KIDQEDDYVKKLIAEI- 1780
R +R+SS + S + Q + D E+D AE+
Sbjct: 682 EIDLDDNSRSSRRSSMTSARSGSEAFQRGNSLNDSFSGSRRSARADAENDAFAAHEAEVM 741
Query: 1779 KEEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDK--DE 1606
++G + +I K + Y +F+ + + I+G+ P + + +E + F
Sbjct: 742 AQDGQITAGYLDIFKNAKGNYIYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGR 801
Query: 1605 MLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDP 1426
M+ + ++ + I F +E LS++ R SF++L+ +++D+P
Sbjct: 802 MMHRMAMAVIAFASVGVGVWISQVASSVLFAIVSENLSLRFRVQSFRNLLYQDASYFDNP 861
Query: 1425 CHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKM-----SLQVL 1261
H +L RL +D+ N+ A VD R+ VI L AI+ ++++F Y W++ SL +L
Sbjct: 862 AHAPGKLITRLASDAPNIKAVVDARMLQVIYALAAIIANIVIAFIYCWQVAILGTSLILL 921
Query: 1260 MFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTS 1081
+ ++ LA + + + I +++ R AIE +ENV+T++ L +
Sbjct: 922 LAFVMIGLA------YKISLMNIEQIKNDEAGRTAIEIIENVKTIQLLTRCELFFDHYQT 975
Query: 1080 HLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLS 901
++ + S K+ +I+ S +F+ ++ G ++ + T+ ++++
Sbjct: 976 SSKQQKRSELKKGMIEAINYSITQSFMYFMMCFTYAVGIRVIYDGDKSSDVTFKGIISMM 1035
Query: 900 MTASYAGSAVAYLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSFE 721
+ A ++ Y P+ KA AAGL+F++ Y D +G R G I +NV F
Sbjct: 1036 LGAVAVMNSAQYFPEFVKAKTAAGLLFNII-YRKPRTGDLMEGDRPEIRGNILFENVKFS 1094
Query: 720 YAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVD 541
Y QR + I+ G+ G+T+ALVGPSGSGKST I +LERFY G ++ID +++ +
Sbjct: 1095 YPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGVLRIDGQDIRN 1154
Query: 540 VNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQG 361
++L+HLR ++LV QEP LF SI+EN G+ + +I++AL++ANA F++ P G
Sbjct: 1155 LSLYHLRTQMALVGQEPRLFAGSIRENVCLGLK-DVPLEKINKALELANANRFLANLPAG 1213
Query: 360 LDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASER 181
+DT VGE+G QLSGGQKQRIAIARA++R+PK+LLLDEATSALDS+SE+ VQ ALD A E
Sbjct: 1214 IDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREG 1273
Query: 180 LSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQV 19
+ + +AHRLS++ N+D I + GKV E G H +L++K+ Y++L++KQ + V
Sbjct: 1274 RTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHAQLMQKKGRYYKLIKKQDLAV 1327
Score = 288 bits (736), Expect = 9e-76
Identities = 198/640 (30%), Positives = 331/640 (50%), Gaps = 25/640 (3%)
Frame = -1
Query: 1860 SDFPSNEISHQKIDQEDD----YVKKLIAEI------------KEEGAKKSNICEIIKYC 1729
SD P+N + D +DD Y L +I ++ A+ +I + +Y
Sbjct: 43 SDLPANYV-----DDDDDAPKLYTPSLFEKILNYLLCRGDIANQQLEAQPVSIPGLFRYG 97
Query: 1728 -RSEYCILFIAVLGSAIQGIYYP---LSSQLMIKSYEAYAFDKDEMLSKSHFWALSILFL 1561
R +Y +LFI + + I G+ P L S + + Y + +K++ L +
Sbjct: 98 KRFDYLLLFIGTICAIISGVSQPIMALVSGRVTNALLVYPPTSKQFRNKANENVYIFLGI 157
Query: 1560 AFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADS 1381
I + QY F ++ ++R ++ ++D H+ T ++ +LN
Sbjct: 158 GIFISITNWIQYMCFQHCCSRVMAQMRHRFVYSVLRQNAGWFDKN-HSGT-ITTKLNDSM 215
Query: 1380 SNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQA 1201
+ + D+LG ++ ++ A+++++ Y W+++ +L P+ + +
Sbjct: 216 ERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPVCCICMSLLARQMTST 275
Query: 1200 VEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTAN 1021
++ I K+ A E+L VRTV+A N + ++ + L+K R + G
Sbjct: 276 TIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYQTELEKGRRFAVWKGFWSGFFG 335
Query: 1020 GFACSCYFFIYAVSFKFGTWLVLREEIL--PMDTYLVLMTLSMTASYAGSAVAYLPDHRK 847
G C F +G +L L+ I+ P D ++V+M++ + A + G ++
Sbjct: 336 GLFFLCLFSFLGTGMLYGAYL-LKVGIIGSPGDVFIVVMSMLLGAYFLGLISPHMMVLLN 394
Query: 846 AIHAAGLIFHLFT-YPAIMPYDSSQGKRNIKN--GEIELKNVSFEYAQRSDKMILDGVSL 676
A +A I+ P I PY S GKR + N G ++ +NV F Y R + IL+G++L
Sbjct: 395 ARVSAATIYQTIDRVPKIDPY-SKAGKR-LPNVVGRVKFENVHFRYPSRKEAKILNGLNL 452
Query: 675 KLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQ 496
+ G ++ALVG SG GKST + LL R Y G V ID +V ++N+ LR V +V Q
Sbjct: 453 TVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIDWLRNVVGIVQQ 512
Query: 495 EPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGG 316
EP+LFN +I N L G + A++ ++ + K+ANA F+ + P+G DTL+G+ G QLSGG
Sbjct: 513 EPILFNDTIHNNLLIG-NPGATREKMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGG 571
Query: 315 QKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVN 136
QKQR+AIAR ++R+PK+LLLDEATSALD+ SE VVQ+AL+ A++ +T+++AHRLST+
Sbjct: 572 QKQRVAIARTLIRDPKILLLDEATSALDAQSESVVQSALNNAAKGRTTIMIAHRLSTIRE 631
Query: 135 ADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQVE 16
AD I + G + E G HEEL+ Y+ LV+ Q + +
Sbjct: 632 ADKIVFFEKGVIVEAGNHEELVHLGGRYFDLVKAQQFKAD 671
>gi|15234323|ref|NP_192092.1| multidrug resistance P-glycoprotein,
putative [Arabidopsis thaliana]
gi|25297454|pir||E85023 probable P-glycoprotein-like protein
[imported] - Arabidopsis thaliana
gi|4558552|gb|AAD22645.1| putative P-glycoprotein-like protein
[Arabidopsis thaliana]
gi|7268567|emb|CAB80676.1| putative P-glycoprotein-like protein
[Arabidopsis thaliana]
Length = 1230
Score = 667 bits (1722), Expect = 0.0
Identities = 416/1219 (34%), Positives = 666/1219 (54%), Gaps = 12/1219 (0%)
Frame = -1
Query: 3657 LLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFESDMN 3478
LL +G + +I G+C P + GE + N N + ++ V +
Sbjct: 28 LLMIVGSIGAIANGVCSPLMTLLFGELIDAMGPNQN--NEEIVERV-------------S 72
Query: 3477 RVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFD-GMSTGHL 3301
+V L +G FLQ + G+ A +R Y+ +LR+DI +FD M+TG +
Sbjct: 73 KVCLSLVYLGLGALGAAFLQVACWMITGERQAARIRSLYLKTILRQDIGFFDVEMTTGEV 132
Query: 3300 SIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLL 3121
++ + + EK+ I L++ FV G ++AF W L + +SG
Sbjct: 133 VGRMSGDTVLILDAMGEKVGKFIQLISTFVGGFVIAFLRGWLLTLVMLTSIPLLAMSGAA 192
Query: 3120 DSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNR 2941
+ + + ++ + A ++ Q LG +TV+S G++Q + Y E + K + +
Sbjct: 193 IAIIVTRASSQEQAAYAKASNVVEQTLGSIRTVASFTGEKQAMSSYKELINLAYKSNVKQ 252
Query: 2940 AFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEAILH 2761
FV L + + + +FG MI G V+ ++ ++ S LG+A
Sbjct: 253 GFVTGLGLGVMFLVFFSTYALGTWFGGEMILRKGYTGGAVINVMVTVVSSSIALGQASPC 312
Query: 2760 ISRLASAIPLTVPIADILLDSDATADEF-FSEEIKDTFQGIISFKNVLFSYPTRPDVPVL 2584
++ + + + + + + D F + ++ + +G I ++V FSYP RP V
Sbjct: 313 LTAFTAGKAAAYKMFETI-EREPLIDTFDLNGKVLEDIRGEIELRDVCFSYPARPKEEVF 371
Query: 2583 KEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAM 2404
S + G ALVG SGSGKSTVI L+ +Y+ +SG++ IDG D+ +K +R +
Sbjct: 372 GGFSLLIPSGTTTALVGESGSGKSTVISLIERFYDPNSGQVLIDGVDLKEFQLKWIRGKI 431
Query: 2403 GVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGERGAQ 2224
G+V QEPVLF++SI ENI +GK AT +EI A K ANA F+ P G++T+VGE G Q
Sbjct: 432 GLVSQEPVLFSSSIMENIGYGKEGATVEEIQAASKLANAAKFIDKLPLGLETLVGEHGTQ 491
Query: 2223 LSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHRLS 2044
LSGGQKQRIAIAR ++++PRILLLDEATSALD ESE +VQEAL + + RTT++VAHRLS
Sbjct: 492 LSGGQKQRIAIARAILKDPRILLLDEATSALDAESERVVQEALDRIMVNRTTVIVAHRLS 551
Query: 2043 TIRNANKIIVMEKGEIVEVGDHKQLIA-MNGVYNNLVQTQLMSTNYEKMNENEERVTRQS 1867
T+RNA+ I V+ +G+IVE G H +L+ G Y+ L++ Q ++ +++ ++ ++ S
Sbjct: 552 TVRNADIIAVIHRGKIVEEGSHSELLKDHEGAYSQLLRLQEINKESKRLEISDGSISSGS 611
Query: 1866 SHSDFPSNEISHQKIDQEDDYVKKLIA-----EIKEEGAKKSNICEIIKYCRSEYCILFI 1702
S + + + D + V L+A ++ +E ++K + I + E IL +
Sbjct: 612 SRGNNSTRQ------DDDSFSVLGLLAGQDSTKMSQELSQKVSFTRIAALNKPEIPILIL 665
Query: 1701 AVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWALSILFLAFTRPIFIFFQYY 1522
L A+ G +P+ L K EA+ E+ S FW++ + L I Y
Sbjct: 666 GTLVGAVNGTIFPIFGILFAKVIEAFFKAPHELKRDSRFWSMIFVLLGVAAVIVYPTTNY 725
Query: 1521 FFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGS 1342
F +L ++RSM F+ ++ + ++D+P +++ + RL+AD++ + V D L
Sbjct: 726 LFAIAGGRLIRRIRSMCFEKVVHMEVGWFDEPGNSSGAMGARLSADAALIRTLVGDSLCL 785
Query: 1341 VIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNR 1162
+ + +++ +I++F SW++++ +L+ P + + GY F+ + +E++++
Sbjct: 786 SVKNVASLVTGLIIAFTASWEVAIIILVIIPFIGINGYIQIKFMKGFSADAKAKYEEASQ 845
Query: 1161 AAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAV 982
A +A+ ++RTV + E +V+ + + S K+ +I G G + + +YA
Sbjct: 846 VANDAVGSIRTVASFCAEEKVMEMYKKRCEDTIKSGIKQGLISGVGFGISFFVLYSVYAS 905
Query: 981 SFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFHLFTYP 802
F G LV D + V + L++TA A ++ PD K AA IF +
Sbjct: 906 CFYVGARLVKAGRTNFNDVFQVFLALTLTAVGISQASSFAPDSSKGKGAAVSIFRIIDRI 965
Query: 801 AIMPYDSSQGK--RNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGS 628
+ + G N+K G+IEL ++SF Y R D + + L + AG+T+ALVG SGS
Sbjct: 966 SKIDSRDESGMVLENVK-GDIELCHISFTYQTRPDVQVFRDLCLSIRAGQTVALVGESGS 1024
Query: 627 GKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFG 448
GKST+ISLL+RFY G + +D + + L LR+ + LV QEPVLFN +I+ N +G
Sbjct: 1025 GKSTVISLLQRFYDPDSGHITLDGVELKKLRLKWLRQQMGLVGQEPVLFNDTIRANIAYG 1084
Query: 447 I-SHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNP 271
A++ EI A ++ANA F+S +G DT+VGERG QLSGGQKQR+AIARAI++ P
Sbjct: 1085 KGGEEATEAEIIAASELANAHRFISSIQKGYDTVVGERGIQLSGGQKQRVAIARAIVKEP 1144
Query: 270 KVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQ 91
K+LLLDEATSALD++SE+VVQ+ALD +T+VVAHRLST+ NAD IAV+KNG +AE+
Sbjct: 1145 KILLLDEATSALDAESERVVQDALDRVMVNRTTIVVAHRLSTIKNADVIAVVKNGVIAEK 1204
Query: 90 GTHEELLR-KRSIYWRLVQ 37
GTHE L+ + +Y LVQ
Sbjct: 1205 GTHETLINIEGGVYASLVQ 1223
>gi|4204793|gb|AAD10836.1| P-glycoprotein [Solanum tuberosum]
Length = 1313
Score = 667 bits (1722), Expect = 0.0
Identities = 426/1206 (35%), Positives = 655/1206 (53%), Gaps = 43/1206 (3%)
Frame = -1
Query: 3519 DLAHAYKLFESDMNRVV-------LLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQY 3361
DL +++ + +D++++ F +VG A + + + S + G+ +R +Y
Sbjct: 93 DLVNSFGSYANDVDKMTQEVLKYAFYFLVVGAAIWASSWAEISCWMWTGERQTTKMRIKY 152
Query: 3360 ISRLLRKDISYFDG-MSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYT 3184
+ L +DI YFD + T + +N + ++ +EK+ I + F+ G ++ F
Sbjct: 153 LEAALNQDIQYFDTEVRTSDVVSAINTDAVVVQDAISEKLGNFIHYMATFLSGFVVGFTA 212
Query: 3183 DWRLACYGTVFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQ 3004
W+LA I + G + + K + + E +S AG+I Q + +TV G+
Sbjct: 213 VWQLALVTLAVVPLIAVIGAIYTVTSAKLSSQSQEALSKAGNIVEQTVVQIRTVLVFVGE 272
Query: 3003 QQEVERYTEELKNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGV 2824
+ ++ YT L+ +K F L A YF ++L++G ++ G+
Sbjct: 273 AKALQAYTAALRVSQKIGYKSGFSKGLGLGATYFTVFCCYALLLWYGGYLVRHHFTNGGL 332
Query: 2823 VVRILYYILFGSYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQ 2647
+ ++ ++ G LG++ ++ A A I I+ D + D ++ DT
Sbjct: 333 AIATMFAVMIGGLALGQSAPSMTAFAKARVAAAKIFRII-DHKPSVDRNAKTGLELDTVS 391
Query: 2646 GIISFKNVLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSG 2467
G + KNV FSYP+RP++ +L + V G+ IALVG+SGSGKSTV+ L+ +Y+ SG
Sbjct: 392 GQLELKNVEFSYPSRPEIKILNNFNLVVPAGKTIALVGSSGSGKSTVVSLIERFYDPTSG 451
Query: 2466 RISIDGNDIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANA 2287
++ +DGNDI + +K LRQ +G+V QEP LF TSI+ENI G+PDAT+ EI +A + ANA
Sbjct: 452 QLMLDGNDIKTLKLKWLRQQIGLVSQEPALFATSIKENILLGRPDATQIEIEEAARVANA 511
Query: 2286 FDFVCNFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIV 2107
FV PDG T VGERG QLSGGQKQRIAIAR +++NP ILLLDEATSALD+ESE +V
Sbjct: 512 HSFVIKLPDGFDTQVGERGLQLSGGQKQRIAIARAMLKNPAILLLDEATSALDSESEKLV 571
Query: 2106 QEALQKASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAM--NGVYNNLV- 1936
QEAL + IGRTT+V+AHRLSTIR A+ + V+++G + E+G H +L++ NG+Y L+
Sbjct: 572 QEALDRFMIGRTTLVIAHRLSTIRKADLVAVLQQGSVSEIGSHDELMSKGENGMYAKLIK 631
Query: 1935 ------QTQLMSTNYEKMNENEER-------VTRQSSH---------SDFPSNEISHQKI 1822
+T L + + R +TR SS+ SDF +++ S
Sbjct: 632 MQEAAHETALSNARKSSARPSSARNSVSSPIITRNSSYGRSPYSRRLSDFSTSDFSLSLD 691
Query: 1821 DQEDDYVKKLIAEIKEEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQG-----IYYPLS 1657
+Y + +A K++ S+ + K E+ I +GS I G Y LS
Sbjct: 692 AAYSNYRNEKLA-FKDQA---SSFGRLAKMNSPEWTYALIGSIGSVICGSLSAFFAYVLS 747
Query: 1656 SQLMIKSYEAYAFDKDEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRS 1477
+ L + +A+ E ++K + + + A IF Q+Y++ E L+ ++R
Sbjct: 748 AVLSVYYNPDHAY-MSEQIAKYCYLLIGVSSAAL---IFNTLQHYYWDVVGENLTKRVRE 803
Query: 1476 MSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMS 1297
++ + A++D + ++R++ RL+ D++NV +A+ DR+ ++ +L+A
Sbjct: 804 KMLAAVLKMEMAWFDQEENDSSRIAARLSLDANNVRSAIGDRISVIMQNSALMLVACTAG 863
Query: 1296 FFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRAL 1117
F W+++L ++ P++ A F+ + A K+ + A EA+ NVRTV A
Sbjct: 864 FVLQWRLALVLIGVFPVVVAATVLQKMFMKGFSGDLEAAHAKATQLAGEAVANVRTVAAF 923
Query: 1116 NMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEIL 937
N E +++ L S LQ F + I G+ G A + YA+ + +WLV
Sbjct: 924 NSETKIVNLFDSSLQTPLRRCFWKGQIAGSGYGIAQFLLYSSYALGLWYASWLVKHGISD 983
Query: 936 PMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGKR--N 763
T V M L ++A+ A + PD K A +F L + D +
Sbjct: 984 FSKTIRVFMVLMVSANGAAETLTLAPDFIKGGRAMRSVFELLDRKTEVEPDDPDATAVPD 1043
Query: 762 IKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHA 583
GE+E K+V F Y R D I ++L+ AG+TLALVGPSG GKS++ISL+ERFY
Sbjct: 1044 RLRGEVEFKHVDFSYPTRPDVSIFRDLNLRARAGKTLALVGPSGCGKSSVISLIERFYEP 1103
Query: 582 VDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALK 403
G V ID +++ NL LR +++V QEP LF +I EN +G +A++ EI +A
Sbjct: 1104 SSGRVIIDGKDIRKYNLKSLRRHIAVVPQEPCLFATTIYENIAYG-HESATEAEITEAAT 1162
Query: 402 VANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDS 223
+ANA F+S P G T VGERG QLSGGQKQRIAIARA LR +++LLDEATSALD++S
Sbjct: 1163 LANAHKFISALPDGYKTFVGERGVQLSGGQKQRIAIARAFLRKAELMLLDEATSALDAES 1222
Query: 222 EKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRS--IYW 49
E+ VQ ALD A +T+VVAHRLST+ NA IAV+ +GKVAEQG+H LL+ S IY
Sbjct: 1223 ERCVQEALDRACAGKTTIVVAHRLSTIRNAHVIAVIDDGKVAEQGSHSHLLKNYSDGIYA 1282
Query: 48 RLVQKQ 31
R++Q Q
Sbjct: 1283 RMIQLQ 1288
>gi|39587987|emb|CAE57218.1| Hypothetical protein CBG00078
[Caenorhabditis briggsae]
Length = 1282
Score = 665 bits (1716), Expect = 0.0
Identities = 405/1162 (34%), Positives = 637/1162 (53%), Gaps = 43/1162 (3%)
Frame = -1
Query: 3375 VRRQYISRLLRKDISYFDGMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTIL 3196
+R +Y+ +LR++ +FD +G ++ LND+MER RE +K+ ++I + + ++
Sbjct: 129 MRHRYVYSVLRQNAGWFDKNHSGTIATKLNDSMERIREGIGDKLGVLIRGVAMLLASIVV 188
Query: 3195 AFYTDWRLACYGTVFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSS 3016
A+ +WRLAC + V L + K+ + AGSIA ++L +TV +
Sbjct: 189 AYIYEWRLACMMLGVAPTCVGCMSLMARQMTATTVKELGGVEKAGSIAEESLMGVRTVQA 248
Query: 3015 LNGQQQEVERYTEELKNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTI 2836
NGQ++ VERY EL G K+A+ + F L +F+ A +GA ++ G I
Sbjct: 249 FNGQEEMVERYRVELNKGRKFAIWKGFWSGLYGGLFFFWLFAFQGCGFLYGAYLLKIGII 308
Query: 2835 -EPGVVVRILYYILFGSYCLGEAILHISRLASAIPLTVPIADIL-----LDSDATADEFF 2674
PG V I+ +L GSY LG H+ L +A I + + +D + F
Sbjct: 309 TSPGDVFIIVMAMLLGSYFLGLISPHLMVLLNARVAAASIYETIERVPKIDPYSKKGRFL 368
Query: 2673 SEEIKDTFQGIISFKNVLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLL 2494
+ I G + F+NV F YPTR D +L ++ ++ G +ALVG SG GKST + LL
Sbjct: 369 DKVI-----GRVKFENVHFRYPTRKDAKILNGLNLTIEPGTSVALVGHSGCGKSTSVGLL 423
Query: 2493 LHYYNIDSGRISIDGNDIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEI 2314
Y ++G ++IDG D+ +NI LR +G+V QEP+LFN +I N+ G P+A +++
Sbjct: 424 TRLYEPETGNVTIDGTDVRELNIDYLRNVVGIVQQEPILFNDTIHNNLLLGNPNAKREKM 483
Query: 2313 IDALKNANAFDFVCNFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSA 2134
I+ K ANA DF+ P G T++G+ G QLSGGQKQR+AIARTL+R+P++LLLDEATSA
Sbjct: 484 IEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSA 543
Query: 2133 LDNESEFIVQEALQKASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNG 1954
LD +SE +VQ AL AS GRTTI++AHRLSTIR A+ I+ EKG IVE G+H +L+ + G
Sbjct: 544 LDAQSESVVQSALNNASKGRTTIMIAHRLSTIREADMIVFFEKGVIVEAGNHAELVRLEG 603
Query: 1953 VYNNLVQTQLMSTNYEKMNENEERV-------------TRQSSHSDFPSNEI-------- 1837
Y +LV+ Q + +++ +E +RQSS + + I
Sbjct: 604 RYYDLVKAQAFKPDDNPISQYDEIAEDIDLGPSATAIHSRQSSFTSSIRSRISGAEAFRR 663
Query: 1836 ------------SHQKIDQEDDYVKKLIAEIKE-EGAKKSNICEIIKYCRSEYCILFIAV 1696
S + D E+ + +A++ E +G + +I K Y ++ +
Sbjct: 664 GTLGADSFAGGRSSARADAENAAFAEEVAKVMEQDGQISAGFLDIFKNAHGNYTVMLLGF 723
Query: 1695 LGSAIQGIYYPLSSQLMIKSYEAYAF---DKDEMLSKSHFWALSILFLAFTRPIFIFFQY 1525
+ I+G+ + L +E + + D +M+ + ++ F + F
Sbjct: 724 VTGLIRGLELTAFALLFGWVFEGFQYLTVDNGKMMHRMAMAVIAYGCSGFGCFVSQFLSS 783
Query: 1524 YFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLG 1345
FF +E L+++ R MSF++L+ +F+D+P H +L RL D+ N VD R+
Sbjct: 784 VFFAIVSENLALRFRVMSFRNLLYQDASFFDNPAHAPGKLITRLATDAPNCKTVVDSRML 843
Query: 1344 SVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSN 1165
V+ L AI+ + ++F Y W +++ LL + C + + I +++
Sbjct: 844 QVLYALSAIIANIAIAFIYCWYLAILGTALIILLAVT-MCGLAYKISLLNMKQIQDDEAG 902
Query: 1164 RAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYA 985
R AIE +ENV+T++ L + + + S K+ +I+ S +++
Sbjct: 903 RIAIEIIENVKTIQLLTRCDHFFERYQKSSKSQKRSELKKGLIEAVNYTITQSFMYYMMC 962
Query: 984 VSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFHLFTY 805
F G L+ + D + + + +TA ++ Y P+ KA A+GL+F++ Y
Sbjct: 963 FCFALGIRLIYQGNKSSQDVFQGNIAMLLTAMGVMNSAQYFPEFVKAKTASGLLFNII-Y 1021
Query: 804 PAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSG 625
D +G G I ++V F Y QR + I+ G+ G+T+ALVGPSGSG
Sbjct: 1022 RKPRTGDLMEGTCPEVRGNILFEDVKFSYPQRPHQPIMKGLQWTALRGQTVALVGPSGSG 1081
Query: 624 KSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGI 445
KST I +LERFY G ++ID +++ ++L HLR ++LV QEP LF +IKEN G+
Sbjct: 1082 KSTCIGMLERFYDVTGGVLRIDGQDIRGLSLFHLRTQMALVGQEPRLFAGTIKENICLGL 1141
Query: 444 SHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKV 265
N S +I+ AL++ANA F+S P G++T VGE+G++LSGGQKQRIAIARA++R+PK+
Sbjct: 1142 -ENVSMEKINHALELANANRFLSNLPAGIETDVGEKGSKLSGGQKQRIAIARALVRDPKI 1200
Query: 264 LLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGT 85
LLLDEATSALDS+SEK VQ ALD A E + + +AHRLS++ N+D I ++NG+V E G
Sbjct: 1201 LLLDEATSALDSESEKAVQEALDRAREGRTCITIAHRLSSIQNSDVIVYIENGRVQEAGN 1260
Query: 84 HEELLRKRSIYWRLVQKQGIQV 19
H++L+ K+ Y+ L+QKQ + +
Sbjct: 1261 HKQLMAKKGKYYELIQKQDLGI 1282
Score = 283 bits (725), Expect = 2e-74
Identities = 185/527 (35%), Positives = 280/527 (53%), Gaps = 8/527 (1%)
Frame = -1
Query: 3483 MNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFD--GMST 3310
M V+ + GF F FL V +N A R LL +D S+FD +
Sbjct: 761 MAMAVIAYGCSGFGCFVSQFLSSVFFAIVSENLALRFRVMSFRNLLYQDASFFDNPAHAP 820
Query: 3309 GHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGT--VFSFGIV 3136
G L L + + V + ++ ++ L+ + +AF W LA GT + +
Sbjct: 821 GKLITRLATDAPNCKTVVDSRMLQVLYALSAIIANIAIAFIYCWYLAILGTALIILLAVT 880
Query: 3135 LSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEK 2956
+ GL + + Q++ AG IA + + KT+ L ERY + K+ ++
Sbjct: 881 MCGLAYKISLLNMKQIQDD---EAGRIAIEIIENVKTIQLLTRCDHFFERYQKSSKSQKR 937
Query: 2955 YALNRAFVFSLSRSADYFFTNALNFVILYF----GANMIYEGTIEPGVVVRILYYILFGS 2788
L + + + +Y T + + ++ F G +IY+G V + +L +
Sbjct: 938 SELKKGLI----EAVNYTITQSFMYYMMCFCFALGIRLIYQGNKSSQDVFQGNIAMLLTA 993
Query: 2787 YCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIKDTFQGIISFKNVLFSYP 2608
+ + + A + + +I+ T D E +G I F++V FSYP
Sbjct: 994 MGVMNSAQYFPEFVKAKTASGLLFNIIYRKPRTGD--LMEGTCPEVRGNILFEDVKFSYP 1051
Query: 2607 TRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNIN 2428
RP P++K + + G+ +ALVG SGSGKST I +L +Y++ G + IDG DI ++
Sbjct: 1052 QRPHQPIMKGLQWTALRGQTVALVGPSGSGKSTCIGMLERFYDVTGGVLRIDGQDIRGLS 1111
Query: 2427 IKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKT 2248
+ LR M +V QEP LF +I+ENI G + + ++I AL+ ANA F+ N P GI+T
Sbjct: 1112 LFHLRTQMALVGQEPRLFAGTIKENICLGLENVSMEKINHALELANANRFLSNLPAGIET 1171
Query: 2247 IVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTT 2068
VGE+G++LSGGQKQRIAIAR LVR+P+ILLLDEATSALD+ESE VQEAL +A GRT
Sbjct: 1172 DVGEKGSKLSGGQKQRIAIARALVRDPKILLLDEATSALDSESEKAVQEALDRAREGRTC 1231
Query: 2067 IVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQ 1927
I +AHRLS+I+N++ I+ +E G + E G+HKQL+A G Y L+Q Q
Sbjct: 1232 ITIAHRLSSIQNSDVIVYIENGRVQEAGNHKQLMAKKGKYYELIQKQ 1278
>gi|46390486|dbj|BAD15946.1| putative MDR-like ABC transporter [Oryza
sativa (japonica cultivar-group)]
gi|50252693|dbj|BAD28861.1| putative MDR-like ABC transporter [Oryza
sativa (japonica cultivar-group)]
Length = 1285
Score = 665 bits (1715), Expect = 0.0
Identities = 423/1247 (33%), Positives = 666/1247 (52%), Gaps = 46/1247 (3%)
Frame = -1
Query: 3669 RYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFE 3490
R + L +G V ++ G+ PF ++ +GE LV A D AH +
Sbjct: 39 RLDAALMAVGGVAAVANGVAMPFLAFLIGE----LVDAFGA--------ADRAHVVHV-- 84
Query: 3489 SDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFD-GMS 3313
++++ L F V GFLQ S G+ A +R Y+ +LR+DI++FD S
Sbjct: 85 --VSKISLRFTYVAIGSGIAGFLQVSCWMVTGERQAARIRGLYLEAILRQDITFFDLETS 142
Query: 3312 TGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVL 3133
TG ++ ++ + ++ EK+ + LL+ F+ G I+AF W L+ + L
Sbjct: 143 TGEVTERMSSDTVLIQDAIGEKVGKFLQLLSTFLGGFIIAFARGWLLSLVMLSSIPPVAL 202
Query: 3132 SGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKY 2953
+ S K + + AG + Q +G +TV S G+++ ++Y E LK +
Sbjct: 203 AAAAMSIAISKLANRSQLAYAEAGKLVEQTIGSIRTVVSFTGERRATDKYNEFLKISYRS 262
Query: 2952 ALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGE 2773
A+++ L + F + +++GA +I E G ++ +L I+ G+ LG+
Sbjct: 263 AVHQGAAMGLGIGSVMFIVFCSYGLAVWYGAKLIIEKGYTGGYIINVLMAIMSGAMALGQ 322
Query: 2772 AILHISRLASA-IPLTVPIADILLDSDATADEFFSEEIKDTFQGIISFKNVLFSYPTRPD 2596
+ ++ AS I A I + + A + S + + F G + FK+V FSYP RP+
Sbjct: 323 SSPCLNAFASGQIAAYKMFATINREPEIDASDR-SGLVLENFVGDVEFKDVHFSYPARPE 381
Query: 2595 VPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQL 2416
+ S ++ G +ALVG SGSGKSTVI L+ +Y+ SG + +DG ++ +N+ ++
Sbjct: 382 QLIFTGFSISIPSGMTMALVGESGSGKSTVISLVERFYDPQSGEVLLDGVNMKLLNLSRI 441
Query: 2415 RQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGE 2236
RQ +G+V QEP+LF T+I ENI +GK DA+E+EI A+ ANA F+ P+G+ T+VGE
Sbjct: 442 RQKIGLVSQEPILFTTTIRENIEYGKKDASEEEIRRAIVLANAAKFIDKLPNGLDTMVGE 501
Query: 2235 RGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVA 2056
G QLSGGQKQRIAIAR ++++PRILLLDEATSALD ESE +VQ+AL + RTTI+VA
Sbjct: 502 HGTQLSGGQKQRIAIARAILKDPRILLLDEATSALDAESEHVVQDALNNIMVNRTTIIVA 561
Query: 2055 HRLSTIRNANKIIVMEKGEIVEVGDHKQLIA-MNGVYNNLVQTQLMST----NYE----K 1903
HRLST+RNA+ I V+ +G++VE G H +LI NG Y L+Q Q ++ YE +
Sbjct: 562 HRLSTVRNADTISVLHRGQLVEQGPHAELIKYSNGAYYQLLQLQEVNARRNGTYELDPNR 621
Query: 1902 MNENEERVTRQSSHSDFPSNEISHQKIDQEDDYVKKL----------------------- 1792
+++ R++ ++ +N +S ++KL
Sbjct: 622 LSDVANRLSDVANRLSDAANRLSDAGNFVSRHSIRKLSFERSMSRHSSLGGSRRNSQTYA 681
Query: 1791 IAEIKEEG-----AKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEA 1627
+ E + EG + K+ + ++ + E IL + + ++ G P+ L+ + A
Sbjct: 682 LTEDEIEGCDDTKSGKNVLRRLLHLHKPETAILLLGCIAASANGAILPVFGLLLSSAINA 741
Query: 1626 YAFDKDEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLP 1447
+ ++ S FWA + L I Q+ F KL ++R++SF ++
Sbjct: 742 FYEPPHKLRKDSVFWAEIYVILGVVSIFIIPVQHTLFNMAGGKLIERIRALSFSRVVYQD 801
Query: 1446 CAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQ 1267
++DDP +++ + RL+AD+++V + D L ++ ++ L+ ++++ +WK++
Sbjct: 802 IGWFDDPLNSSGAIGARLSADAASVKSIAGDVLSLIVQSISTALVGIVIAMIANWKLAFI 861
Query: 1266 VLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLV 1087
VL F P ++ Y + + +E+++ A +A+ N+RTV + + ++I
Sbjct: 862 VLCFVPCVFAQSYAQSRLMRGFGADAKEMYEQASTIASDAISNIRTVTSFCVGEKIIESY 921
Query: 1086 TSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMT 907
+ + ++ I G GF+ + F YAVSF G V + + V
Sbjct: 922 RNKCKGPVKKGVRQGAISGVGYGFSFALLFCFYAVSFYVGARFVHNGTADVGEVFKVFFA 981
Query: 906 LSMTASYAGSAVAYLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGKRNIK-NGEIELKNV 730
L+M A + + D K AA IF + + + S G K G IE ++V
Sbjct: 982 LTMMAVGVSQSSSLARDFSKVQDAAASIFKIIDRKSKIDASSDDGMAPEKIEGNIEFQHV 1041
Query: 729 SFEYAQRSDKMILDGVSLKLPAGR------TLALVGPSGSGKSTIISLLERFYHAVDGEV 568
SF+Y R+D I + L++P+G+ T+ALVG SGSGKST+++LLERFY G +
Sbjct: 1042 SFKYPARTDVQIFTNLCLRIPSGKVHVVLMTVALVGESGSGKSTVVALLERFYDPDSGAI 1101
Query: 567 KIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAF 388
+D ++ + L LR+ + LV QEPVLFN +I+ N +G S+ EI + ANA
Sbjct: 1102 FLDGMDLKTLKLTWLRQQIGLVGQEPVLFNGTIRANIAYGKQDQVSEEEIVAVAEAANAH 1161
Query: 387 SFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQ 208
F+S P G DT VGERG QLSGGQKQRIAIARAIL++PKVLLLDEATSALDS+SE++VQ
Sbjct: 1162 RFISSLPHGYDTSVGERGVQLSGGQKQRIAIARAILKDPKVLLLDEATSALDSESERIVQ 1221
Query: 207 NALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLR 67
ALD +TV+VAHRLST+ AD IAV+KNG VAE+G H LLR
Sbjct: 1222 EALDRVMVGRTTVIVAHRLSTITGADKIAVIKNGVVAEEGRHGRLLR 1268
Score = 306 bits (785), Expect = 2e-81
Identities = 198/590 (33%), Positives = 320/590 (53%), Gaps = 8/590 (1%)
Frame = -1
Query: 1770 GAKKSNICEIIKYC-RSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAY-AFDKDEMLS 1597
GAK+ + + + R + ++ + + + G+ P + L+ + +A+ A D+ ++
Sbjct: 24 GAKRVPMRRLFTFADRLDAALMAVGGVAAVANGVAMPFLAFLIGELVDAFGAADRAHVVH 83
Query: 1596 KSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHT 1417
+L ++A I F Q + T E+ + ++R + + ++ F+D T
Sbjct: 84 VVSKISLRFTYVAIGSGIAGFLQVSCWMVTGERQAARIRGLYLEAILRQDITFFDLETST 143
Query: 1416 ATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYL 1237
++ R+++D+ + A+ +++G + L L I++F W +SL +L P + L
Sbjct: 144 G-EVTERMSSDTVLIQDAIGEKVGKFLQLLSTFLGGFIIAFARGWLLSLVMLSSIPPVAL 202
Query: 1236 AGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNS 1057
A + + +A+ ++ + + + ++RTV + E R T +
Sbjct: 203 AAAAMSIAISKLANRSQLAYAEAGKLVEQTIGSIRTVVSFTGERRA----TDKYNEFLKI 258
Query: 1056 YFKRAVIQGTANGFACSCYFFIYAVSFKFGTW----LVLREEILPMDTYLVLMTLSMTAS 889
++ AV QG A G FI S+ W L++ + VLM + A
Sbjct: 259 SYRSAVHQGAAMGLGIGSVMFIVFCSYGLAVWYGAKLIIEKGYTGGYIINVLMAIMSGAM 318
Query: 888 YAGSAVAYLPDHRKAIHAAGLIFHLFTY-PAIMPYDSSQGKRNIKNGEIELKNVSFEYAQ 712
G + L AA +F P I D S G++E K+V F Y
Sbjct: 319 ALGQSSPCLNAFASGQIAAYKMFATINREPEIDASDRSGLVLENFVGDVEFKDVHFSYPA 378
Query: 711 RSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNL 532
R +++I G S+ +P+G T+ALVG SGSGKST+ISL+ERFY GEV +D N+ +NL
Sbjct: 379 RPEQLIFTGFSISIPSGMTMALVGESGSGKSTVISLVERFYDPQSGEVLLDGVNMKLLNL 438
Query: 531 HHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDT 352
+R+ + LVSQEP+LF +I+EN +G +AS+ EI +A+ +ANA F+ + P GLDT
Sbjct: 439 SRIRQKIGLVSQEPILFTTTIRENIEYG-KKDASEEEIRRAIVLANAAKFIDKLPNGLDT 497
Query: 351 LVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLST 172
+VGE G QLSGGQKQRIAIARAIL++P++LLLDEATSALD++SE VVQ+AL+ +T
Sbjct: 498 MVGEHGTQLSGGQKQRIAIARAILKDPRILLLDEATSALDAESEHVVQDALNNIMVNRTT 557
Query: 171 VVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLR-KRSIYWRLVQKQGI 25
++VAHRLSTV NAD+I+VL G++ EQG H EL++ Y++L+Q Q +
Sbjct: 558 IIVAHRLSTVRNADTISVLHRGQLVEQGPHAELIKYSNGAYYQLLQLQEV 607
Score = 291 bits (745), Expect = 8e-77
Identities = 181/521 (34%), Positives = 286/521 (54%), Gaps = 18/521 (3%)
Frame = -1
Query: 3423 LQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGM--STGHLSIVLNDNMERFREVFNE 3250
+Q ++ G +R SR++ +DI +FD S+G + L+ + + + +
Sbjct: 773 VQHTLFNMAGGKLIERIRALSFSRVVYQDIGWFDDPLNSSGAIGARLSADAASVKSIAGD 832
Query: 3249 KIALIIALLTDFVIGTILAFYTDWRLA----CY-GTVFSFGIVLSGLLDSWGKMKNNEKQ 3085
++LI+ ++ ++G ++A +W+LA C+ VF+ S L+ +G
Sbjct: 833 VLSLIVQSISTALVGIVIAMIANWKLAFIVLCFVPCVFAQSYAQSRLMRGFGA-----DA 887
Query: 3084 NEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNRAFVFSLSRSADY 2905
E A +IA A+ +TV+S ++ +E Y + K K + + + + +
Sbjct: 888 KEMYEQASTIASDAISNIRTVTSFCVGEKIIESYRNKCKGPVKKGVRQGAISGVGYGFSF 947
Query: 2904 FFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEA---ILHISRLASAIP 2734
V Y GA ++ GT + G V ++ + + + + ++ S++ A
Sbjct: 948 ALLFCFYAVSFYVGARFVHNGTADVGEVFKVFFALTMMAVGVSQSSSLARDFSKVQDAAA 1007
Query: 2733 LTVPIADILLDSDATADEFFSEEIKDTFQGIISFKNVLFSYPTRPDVPVLKEISFNVQGG 2554
I D DA++D+ + E +G I F++V F YP R DV + + + G
Sbjct: 1008 SIFKIIDRKSKIDASSDDGMAPE---KIEGNIEFQHVSFKYPARTDVQIFTNLCLRIPSG 1064
Query: 2553 EC------IALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAMGVVF 2392
+ +ALVG SGSGKSTV+ LL +Y+ DSG I +DG D+ + + LRQ +G+V
Sbjct: 1065 KVHVVLMTVALVGESGSGKSTVVALLERFYDPDSGAIFLDGMDLKTLKLTWLRQQIGLVG 1124
Query: 2391 QEPVLFNTSIEENIRFGKPD-ATEQEIIDALKNANAFDFVCNFPDGIKTIVGERGAQLSG 2215
QEPVLFN +I NI +GK D +E+EI+ + ANA F+ + P G T VGERG QLSG
Sbjct: 1125 QEPVLFNGTIRANIAYGKQDQVSEEEIVAVAEAANAHRFISSLPHGYDTSVGERGVQLSG 1184
Query: 2214 GQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHRLSTIR 2035
GQKQRIAIAR ++++P++LLLDEATSALD+ESE IVQEAL + +GRTT++VAHRLSTI
Sbjct: 1185 GQKQRIAIARAILKDPKVLLLDEATSALDSESERIVQEALDRVMVGRTTVIVAHRLSTIT 1244
Query: 2034 NANKIIVMEKGEIVEVGDHKQLIAM-NGVYNNLVQTQLMST 1915
A+KI V++ G + E G H +L+ + G Y +LV Q S+
Sbjct: 1245 GADKIAVIKNGVVAEEGRHGRLLRLPGGAYASLVALQSSSS 1285
>gi|50750485|ref|XP_422016.1| PREDICTED: similar to liver bile salt
export pump [Gallus gallus]
Length = 1371
Score = 664 bits (1714), Expect = 0.0
Identities = 400/1087 (36%), Positives = 612/1087 (55%), Gaps = 6/1087 (0%)
Frame = -1
Query: 3282 NMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLLDSWGKM 3103
++ + E +++A+ I LT FV G +L F + W+L S I + +
Sbjct: 295 DVNKINEAIADQVAIFIQRLTTFVCGFLLGFISGWKLTLVIIAVSPLIGVGAAVYGLAVA 354
Query: 3102 KNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNRAFVFSL 2923
K ++ + + AG++A + L +TV++ G+++EVERY + L + + + + + L
Sbjct: 355 KLTGRELKAYAKAGAVADEVLSSIRTVAAFGGEKKEVERYDKNLVYAQHWGIRKGIIMGL 414
Query: 2922 SRSADYFFTNALNFVILYFGANMIYE-GTIEPGVVVRILYYILFGSYCLGEAILHISRLA 2746
+F + ++G+ ++ E PG ++++ + +L G+ LG+A + A
Sbjct: 415 FSGYMWFVIFLCYALAFWYGSKLVLEEDEYSPGTLLQVFFGVLVGALNLGQASPCLEAFA 474
Query: 2745 SAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPTRPDVPVLKEISF 2569
+ I + + D T D E K D +G I F NV F YP+RPDV +L IS
Sbjct: 475 TGRGAAANIFETI-DRKPTIDCMSEEGYKLDKVRGEIEFHNVTFHYPSRPDVKILDNISM 533
Query: 2568 NVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAMGVVFQ 2389
++ GE A VGASG+GKST+IQL+ +Y+ G I++DG+DI ++NI+ LR +GVV Q
Sbjct: 534 VIKTGETTAFVGASGAGKSTIIQLIQRFYDPTDGMITLDGHDIRSLNIQWLRAQIGVVEQ 593
Query: 2388 EPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGERGAQLSGGQ 2209
EPVLF T+I ENIR+G+ DAT +++I A K ANA+ F+ + P T VGE G+Q+SGGQ
Sbjct: 594 EPVLFATTIAENIRYGRDDATMEDVIRAAKQANAYKFIMDLPQQFDTHVGEGGSQMSGGQ 653
Query: 2208 KQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHRLSTIRNA 2029
KQRIAIAR LVRNP+ILLLD ATSALDNESE IVQEALQKA +GRT I +AHRLS ++ A
Sbjct: 654 KQRIAIARALVRNPKILLLDMATSALDNESEAIVQEALQKAHLGRTAISIAHRLSAVKAA 713
Query: 2028 NKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNENEERVTRQSSHSDFP 1849
+ II E G VE G H++L+ GVY LV Q K + R ++S+ +
Sbjct: 714 DVIIGFEHGRAVERGTHEELLKRKGVYFMLVTLQ------SKGDSTLTRAAKESAENKVV 767
Query: 1848 SNEISHQKIDQEDDYVKKLIAEIKEEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIY 1669
+ + + Y L A +++ +S + ++ +++ G + +Y
Sbjct: 768 EPNLEKVQSFRRGSYRASLRASLRQR--SRSQLSNVVPDPP-------LSIAGDQAESVY 818
Query: 1668 YPLSSQLMIKSYEAYAFDKDEMLSKSHFWALSILFLAFTRPIFI--FFQYYFFGKTAEKL 1495
+ ++ + ++ DE K + +LF+ F F Q Y F K+ E L
Sbjct: 819 LKSYEEDDGQAKKTFSI-LDEEKQKVQINGVCLLFVLVGIVSFFTQFLQGYNFAKSGELL 877
Query: 1494 SIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAIL 1315
+ +LR + F+ ++ ++DD ++ L+ RL D+S V A ++G ++ + I
Sbjct: 878 TRRLRKIGFQAMLGQDVGWFDDRRNSPGALTTRLATDASQVQGATGSQIGMMVNSFTNIG 937
Query: 1314 LAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENV 1135
+A+I++F++SWK+SL ++ F P L L+G + +D A E + + + EAL N+
Sbjct: 938 VAIIIAFYFSWKLSLVIMCFLPFLALSGAVQAKMLTGFAAQDKKALEATGQISSEALSNI 997
Query: 1134 RTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLV 955
RTV + E + I +L + K+A + G GFA S F +VS+++G +LV
Sbjct: 998 RTVAGIGKEKKFIDAFEKNLDMPYRAAIKKANVYGICFGFAQSIVFIANSVSYRYGGFLV 1057
Query: 954 LREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFHLF-TYPAIMPYDSS 778
E + + V+ + + + G A +Y P++ KA +A +F L P I Y
Sbjct: 1058 QTEGLHYSFVFRVISAIVTSGTALGRASSYTPNYAKAKTSAARLFQLIDRLPKISVYSKE 1117
Query: 777 QGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLE 598
K + G IE N F Y R D +L G+S+ + G+TLA VG SG GKST + LLE
Sbjct: 1118 GEKWDDFKGSIEFLNCKFTYPSRPDIQVLKGLSVAVKPGQTLAFVGSSGCGKSTSVQLLE 1177
Query: 597 RFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLE- 421
RFY +G V ID + VN+ LR + +VSQEPVLF+CSI +N +G + + +E
Sbjct: 1178 RFYDPEEGSVLIDGHDTKKVNVQFLRSKIGVVSQEPVLFDCSIADNIKYGSNTKDTTMEK 1237
Query: 420 IDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATS 241
+ +A K A FV P+ +T VG +G+QLS GQKQRIAIARAI+R+PK+LLLDEATS
Sbjct: 1238 VIEAAKKAQLHDFVMSLPEKYETNVGAQGSQLSRGQKQRIAIARAIIRDPKILLLDEATS 1297
Query: 240 ALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKR 61
ALD++SEK VQ ALD A E + +V+AHRLST+ NAD IAV+ G + E+GTH+EL+
Sbjct: 1298 ALDTESEKTVQAALDKAREGRTCIVIAHRLSTIENADIIAVMSQGIIIERGTHDELMAME 1357
Query: 60 SIYWRLV 40
Y++LV
Sbjct: 1358 GAYYKLV 1364
Score = 306 bits (783), Expect = 3e-81
Identities = 192/523 (36%), Positives = 289/523 (54%), Gaps = 5/523 (0%)
Frame = -1
Query: 3483 MNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGM--ST 3310
+N V LLF LVG F FLQ G+ +R+ +L +D+ +FD S
Sbjct: 845 INGVCLLFVLVGIVSFFTQFLQGYNFAKSGELLTRRLRKIGFQAMLGQDVGWFDDRRNSP 904
Query: 3309 GHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLS 3130
G L+ L + + + +I +++ T+ + I+AFY W+L+ F + LS
Sbjct: 905 GALTTRLATDASQVQGATGSQIGMMVNSFTNIGVAIIIAFYFSWKLSLVIMCFLPFLALS 964
Query: 3129 GLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYA 2950
G + + + + + G I+ +AL +TV+ + +++ ++ + + L + A
Sbjct: 965 GAVQAKMLTGFAAQDKKALEATGQISSEALSNIRTVAGIGKEKKFIDAFEKNLDMPYRAA 1024
Query: 2949 LNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEA 2770
+ +A V+ + N V +G ++ + V R++ I+ LG A
Sbjct: 1025 IKKANVYGICFGFAQSIVFIANSVSYRYGGFLVQTEGLHYSFVFRVISAIVTSGTALGRA 1084
Query: 2769 ILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPTRPDV 2593
+ A A + L+D + E K D F+G I F N F+YP+RPD+
Sbjct: 1085 SSYTPNYAKAKTSAARLFQ-LIDRLPKISVYSKEGEKWDDFKGSIEFLNCKFTYPSRPDI 1143
Query: 2592 PVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLR 2413
VLK +S V+ G+ +A VG+SG GKST +QLL +Y+ + G + IDG+D +N++ LR
Sbjct: 1144 QVLKGLSVAVKPGQTLAFVGSSGCGKSTSVQLLERFYDPEEGSVLIDGHDTKKVNVQFLR 1203
Query: 2412 QAMGVVFQEPVLFNTSIEENIRFGK--PDATEQEIIDALKNANAFDFVCNFPDGIKTIVG 2239
+GVV QEPVLF+ SI +NI++G D T +++I+A K A DFV + P+ +T VG
Sbjct: 1204 SKIGVVSQEPVLFDCSIADNIKYGSNTKDTTMEKVIEAAKKAQLHDFVMSLPEKYETNVG 1263
Query: 2238 ERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVV 2059
+G+QLS GQKQRIAIAR ++R+P+ILLLDEATSALD ESE VQ AL KA GRT IV+
Sbjct: 1264 AQGSQLSRGQKQRIAIARAIIRDPKILLLDEATSALDTESEKTVQAALDKAREGRTCIVI 1323
Query: 2058 AHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQT 1930
AHRLSTI NA+ I VM +G I+E G H +L+AM G Y LV T
Sbjct: 1324 AHRLSTIENADIIAVMSQGIIIERGTHDELMAMEGAYYKLVTT 1366
Score = 286 bits (733), Expect = 2e-75
Identities = 173/472 (36%), Positives = 258/472 (54%), Gaps = 2/472 (0%)
Frame = -1
Query: 1419 TATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLY 1240
+A S D + + A+ D++ I L + ++ F WK++L ++ PL+
Sbjct: 284 SAPSASAGAQGDVNKINEAIADQVAIFIQRLTTFVCGFLLGFISGWKLTLVIIAVSPLIG 343
Query: 1239 LAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRN 1060
+ V + + A+ K+ A E L ++RTV A E + + +L ++
Sbjct: 344 VGAAVYGLAVAKLTGRELKAYAKAGAVADEVLSSIRTVAAFGGEKKEVERYDKNLVYAQH 403
Query: 1059 SYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYL-VLMTLSMTASYA 883
++ +I G +G+ F YA++F +G+ LVL E+ T L V + + A
Sbjct: 404 WGIRKGIIMGLFSGYMWFVIFLCYALAFWYGSKLVLEEDEYSPGTLLQVFFGVLVGALNL 463
Query: 882 GSAVAYLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGKRNIK-NGEIELKNVSFEYAQRS 706
G A L AA IF + S +G + K GEIE NV+F Y R
Sbjct: 464 GQASPCLEAFATGRGAAANIFETIDRKPTIDCMSEEGYKLDKVRGEIEFHNVTFHYPSRP 523
Query: 705 DKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHH 526
D ILD +S+ + G T A VG SG+GKSTII L++RFY DG + +D ++ +N+
Sbjct: 524 DVKILDNISMVIKTGETTAFVGASGAGKSTIIQLIQRFYDPTDGMITLDGHDIRSLNIQW 583
Query: 525 LRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLV 346
LR + +V QEPVLF +I EN +G +A+ ++ +A K ANA+ F+ PQ DT V
Sbjct: 584 LRAQIGVVEQEPVLFATTIAENIRYG-RDDATMEDVIRAAKQANAYKFIMDLPQQFDTHV 642
Query: 345 GERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVV 166
GE G+Q+SGGQKQRIAIARA++RNPK+LLLD ATSALD++SE +VQ AL A + +
Sbjct: 643 GEGGSQMSGGQKQRIAIARALVRNPKILLLDMATSALDNESEAIVQEALQKAHLGRTAIS 702
Query: 165 VAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQVETL 10
+AHRLS V AD I ++G+ E+GTHEELL+++ +Y+ LV Q TL
Sbjct: 703 IAHRLSAVKAADVIIGFEHGRAVERGTHEELLKRKGVYFMLVTLQSKGDSTL 754
>gi|15217786|ref|NP_171754.1| multidrug resistance P-glycoprotein,
putative [Arabidopsis thaliana]
Length = 1273
Score = 663 bits (1711), Expect = 0.0
Identities = 421/1263 (33%), Positives = 666/1263 (52%), Gaps = 39/1263 (3%)
Frame = -1
Query: 3708 LKKTFGFQIKCTTRYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTI 3529
L K F F ++ L G + +I G+C P + G+ K N
Sbjct: 30 LYKLFAF----ADSFDVFLMICGSLGAIGNGVCLPLMTLLFGDLIDSFGK-----NQNNK 80
Query: 3528 DPVDLAHAYKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRL 3349
D VD+ +++V L F +G FLQ + G+ A +R Y+ +
Sbjct: 81 DIVDV----------VSKVCLKFVYLGLGRLGAAFLQVACWMITGERQAAKIRSNYLKTI 130
Query: 3348 LRKDISYFD-GMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRL 3172
LR+DI +FD +TG + ++ + ++ EK+ I L++ FV G LAF W L
Sbjct: 131 LRQDIGFFDVETNTGEVVGRMSGDTVHIQDAMGEKVGKFIQLVSTFVGGFALAFAKGWLL 190
Query: 3171 ACYGTVFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEV 2992
+ ++G + + + + + A ++ Q +G +TV+S G++Q +
Sbjct: 191 TLVMLTSIPFLAMAGAAMALLVTRASSRGQAAYAKAATVVEQTIGSIRTVASFTGEKQAI 250
Query: 2991 ERYTEELKNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRI 2812
Y + + + K ++ + F L + + + ++FG MI E G V+ +
Sbjct: 251 NSYKKYITSAYKSSIQQGFSTGLGLGVMIYVFFSSYALAIWFGGKMILEKGYTGGSVINV 310
Query: 2811 LYYILFGSYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIKDTFQGIISF 2632
+ ++ GS LG+ ++ A+ + + + + ++ +G I
Sbjct: 311 IIIVVAGSMSLGQTSPCVTAFAAGQAAAYKMFETIKRKPLIDAYDVNGKVLGDIRGDIEL 370
Query: 2631 KNVLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISID 2452
K+V FSYP RPD + S + G ALVG SGSGKSTVI L+ +Y+ +G + ID
Sbjct: 371 KDVHFSYPARPDEEIFDGFSLFIPSGATAALVGESGSGKSTVINLIERFYDPKAGEVLID 430
Query: 2451 GNDIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVC 2272
G ++ +K +R +G+V QEPVLF++SI ENI +GK +AT QEI A + ANA F+
Sbjct: 431 GINLKEFQLKWIRSKIGLVCQEPVLFSSSIMENIAYGKENATLQEIKVATELANAAKFIN 490
Query: 2271 NFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQ 2092
N P G+ T VGE G QLSGGQKQRIAIAR ++++PR+LLLDEATSALD ESE +VQEAL
Sbjct: 491 NLPQGLDTKVGEHGTQLSGGQKQRIAIARAILKDPRVLLLDEATSALDTESERVVQEALD 550
Query: 2091 KASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMN-GVYNNLVQTQLMST 1915
+ + RTT+VVAHRLST+RNA+ I V+ G++VE G H +L+ + G Y+ L++ Q ++
Sbjct: 551 RVMVNRTTVVVAHRLSTVRNADMIAVIHSGKMVEKGSHSELLKDSVGAYSQLIRCQEINK 610
Query: 1914 NYE---------------KMNENEERVTRQSSHSDFPSNEISH----------------- 1831
++ +N + E S F ++ H
Sbjct: 611 GHDAKPSDMASGSSFRNSNLNISREGSVISGGTSSFGNSSRHHSLNVLGLFAGLDLGSGS 670
Query: 1830 QKIDQEDDYVKKLIAEIKEEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQ 1651
Q++ QE+ +E +K ++ I + E +L + + +AI G +PL
Sbjct: 671 QRVGQEE------TGTTSQEPLRKVSLTRIAALNKPEIPVLLLGTVVAAINGAIFPLFGI 724
Query: 1650 LMIKSYEAYAFDKDEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMS 1471
L+ + EA+ D++ S FWA+ + L T I Q Y F KL +++SM
Sbjct: 725 LISRVIEAFFKPADQLKKDSRFWAIIFVALGVTSLIVSPSQMYLFAVAGGKLIRRIQSMC 784
Query: 1470 FKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFF 1291
F+ + + +++D+P +++ + RL+ D++ + A V D L + + +I++F
Sbjct: 785 FEKAVHMEVSWFDEPENSSGTMGARLSTDAALIRALVGDALSLAVQNAASAASGLIIAFT 844
Query: 1290 YSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNM 1111
SW+++L +L+ PL+ + G+ F+ + +E++++ A +A+ ++RTV +
Sbjct: 845 ASWELALIILVMLPLIGINGFLQVKFMKGFSADAKSKYEEASQVANDAVGSIRTVASFCA 904
Query: 1110 ENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPM 931
E +V+ + + K+ I G GF+ F +YA SF LV + +
Sbjct: 905 EEKVMQMYNKQCEGPIKDGVKQGFISGLGFGFSFFILFCVYATSFYAAARLVEDGKTTFI 964
Query: 930 DTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGK--RNIK 757
D + V L+M A + + PD KA AA IF + + + G N+K
Sbjct: 965 DVFQVFFALTMAAIGISQSSTFAPDSSKAKVAAASIFAIIDRKSKIDSSDETGTVLENVK 1024
Query: 756 NGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVD 577
G+IEL+++SF Y R I + L + AG+T+ALVG SGSGKST+ISLL+RFY
Sbjct: 1025 -GDIELRHLSFTYPARPGIQIFRDLCLTIRAGKTVALVGESGSGKSTVISLLQRFYDPDS 1083
Query: 576 GEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLF--GISHNASQLEIDQALK 403
G++ +D + + L LR+ + LV QEPVLFN +I+ N + G A++ EI A +
Sbjct: 1084 GQITLDGVELKKLQLKWLRQQMGLVGQEPVLFNDTIRANIAYGKGSEEAATESEIIAAAE 1143
Query: 402 VANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDS 223
+ANA F+S QG DT+VGE+G QLSGGQKQR+AIARAI++ PK+LLLDEATSALD++S
Sbjct: 1144 LANAHKFISSIQQGYDTVVGEKGIQLSGGQKQRVAIARAIVKEPKILLLDEATSALDAES 1203
Query: 222 EKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLR-KRSIYWR 46
E++VQ+ALD +TVVVAHRLST+ NAD IA++KNG +AE GTHE L++ +Y
Sbjct: 1204 ERLVQDALDRVIVNRTTVVVAHRLSTIKNADVIAIVKNGVIAENGTHETLIKIDGGVYAS 1263
Query: 45 LVQ 37
LVQ
Sbjct: 1264 LVQ 1266
>gi|15228695|ref|NP_191774.1| multidrug resistant (MDR) ABC
transporter, putative [Arabidopsis thaliana]
gi|11277353|pir||T48007 P-glycoprotein homolog T17J13.110
[similarity] - Arabidopsis thaliana
gi|6899925|emb|CAB71875.1| P-glycoprotein-like proetin [Arabidopsis
thaliana]
Length = 1292
Score = 662 bits (1709), Expect = 0.0
Identities = 425/1240 (34%), Positives = 667/1240 (53%), Gaps = 30/1240 (2%)
Frame = -1
Query: 3666 YEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFES 3487
++ +L LG + ++ G+ P + G+ V + N + D D
Sbjct: 75 FDIILMILGTIGAVGNGLGFPIMTILFGDVIDVFGQ-----NQNSSDVSD---------- 119
Query: 3486 DMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFD-GMST 3310
+ +V L F +G LQ S G+ A +R Y+ +LR+DI++FD +T
Sbjct: 120 KIAKVALKFVYLGLGTLVAALLQVSGWMISGERQAGRIRSLYLQTILRQDIAFFDVETNT 179
Query: 3309 GHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLS 3130
G + ++ + ++ EK+ I L++ F+ G ++AF W L +V+S
Sbjct: 180 GEVVGRMSGDTVLIQDAMGEKVGKAIQLVSTFIGGFVIAFTEGWLLTLVMVSSIPLLVMS 239
Query: 3129 GLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYA 2950
G + K + + A + Q +G +TV+S G++Q + Y + L +
Sbjct: 240 GAALAIVISKMASRGQTSYAKAAVVVEQTVGSIRTVASFTGEKQAISNYNKHLVSAY--- 296
Query: 2949 LNRAFVFSLSRSADYFFTNALNFVI-------LYFGANMIYEGTIEPGVVVRILYYILFG 2791
RA VF + + LN VI +++G MI E G V+ I++ +L G
Sbjct: 297 --RAGVFEGASTG--LGLGTLNIVIFCTYALAVWYGGKMILEKGYTGGQVLIIIFAVLTG 352
Query: 2790 SYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIKDTFQGIISFKNVLFSY 2611
S LG+A +S A+ + + + + ++ D +G I NV FSY
Sbjct: 353 SMSLGQASPCLSAFAAGQAAAYKMFEAIKRKPEIDASDTTGKVLDDIRGDIELNNVNFSY 412
Query: 2610 PTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNI 2431
P RP+ + + S ++ G +ALVG SGSGKSTV+ L+ +Y+ SG + IDG ++
Sbjct: 413 PARPEEQIFRGFSLSISSGSTVALVGQSGSGKSTVVSLIERFYDPQSGEVRIDGINLKEF 472
Query: 2430 NIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIK 2251
+K +R +G+V QEPVLF +SI+ENI +GK +AT +EI A + ANA F+ P G+
Sbjct: 473 QLKWIRSKIGLVSQEPVLFTSSIKENIAYGKENATVEEIRKATELANASKFIDKLPQGLD 532
Query: 2250 TIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRT 2071
T+VGE G QLSGGQKQRIA+AR ++++PRILLLDEATSALD ESE IVQEAL + + RT
Sbjct: 533 TMVGEHGTQLSGGQKQRIAVARAILKDPRILLLDEATSALDAESERIVQEALDRIMVNRT 592
Query: 2070 TIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIA-MNGVYNNLVQTQLMSTNYEKMNE 1894
T+VVAHRLST+RNA+ I V+ +G+IVE G H +L+ G Y+ L++ Q + E +
Sbjct: 593 TVVVAHRLSTVRNADMIAVIHQGKIVEKGSHSELLRDPEGAYSQLIRLQEDTKQTEDSTD 652
Query: 1893 NE----ERVTRQSSHSDFPSNEISHQK-----------IDQEDDYVK----KLIAEIKEE 1771
+ E + R S S +S + ID ++ + K+ IKE
Sbjct: 653 EQKLSMESMKRSSLRKSSLSRSLSKRSSSFSMFGFPAGIDTNNEAIPEKDIKVSTPIKE- 711
Query: 1770 GAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKS 1591
KK + + + E +L + + + + G+ P+ L+ +A+ +++ S +
Sbjct: 712 --KKVSFFRVAALNKPEIPMLILGSIAAVLNGVILPIFGILISSVIKAFFKPPEQLKSDT 769
Query: 1590 HFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTAT 1411
FWA+ + L + Q FF KL ++RSM F+ ++ + ++D+ +++
Sbjct: 770 RFWAIIFMLLGVASMVVFPAQTIFFSIAGCKLVQRIRSMCFEKVVRMEVGWFDETENSSG 829
Query: 1410 RLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAG 1231
+ RL+AD++ V V D L + L ++ ++++F SW+++ VL PL+ L G
Sbjct: 830 AIGARLSADAATVRGLVGDALAQTVQNLASVTAGLVIAFVASWQLAFIVLAMLPLIGLNG 889
Query: 1230 YCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYF 1051
Y F+ S +++++ A +A+ ++RTV + E +V+ + + +
Sbjct: 890 YIYMKFMVGF----SADAKEASQVANDAVGSIRTVASFCAEEKVMKMYKKKCEGPMRTGI 945
Query: 1050 KRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAV 871
++ ++ G G + F YA SF G LV + + V L+M A +
Sbjct: 946 RQGIVSGIGFGVSFFVLFSSYAASFYAGARLVDDGKTTFDSVFRVFFALTMAAVAISQSS 1005
Query: 870 AYLPDHRKAIHAAGLIFHLFTYPA-IMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMI 694
+ PD KA +AA IF + + I P D S + G+IEL+++SF+Y R D I
Sbjct: 1006 SLSPDSSKASNAAASIFAVIDRESKIDPSDESGRVLDNVKGDIELRHISFKYPSRPDVQI 1065
Query: 693 LDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRES 514
+ L + AG+T+ALVG SGSGKST+I+LL+RFY G++ +D + + L LR+
Sbjct: 1066 FQDLCLSIRAGKTIALVGESGSGKSTVIALLQRFYDPDSGQITLDGVEIKTLQLKWLRQQ 1125
Query: 513 VSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERG 334
LVSQEPVLFN +I+ N +G +A++ EI A +++NA F+S QG DT+VGERG
Sbjct: 1126 TGLVSQEPVLFNETIRANIAYGKGGDATETEIVSAAELSNAHGFISGLQQGYDTMVGERG 1185
Query: 333 AQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHR 154
QLSGGQKQR+AIARAI+++PKVLLLDEATSALD++SE+VVQ+ALD +TVVVAHR
Sbjct: 1186 VQLSGGQKQRVAIARAIVKDPKVLLLDEATSALDAESERVVQDALDRVMVNRTTVVVAHR 1245
Query: 153 LSTVVNADSIAVLKNGKVAEQGTHEELLR-KRSIYWRLVQ 37
LST+ NAD IAV+KNG + E+G HE L+ K +Y LVQ
Sbjct: 1246 LSTIKNADVIAVVKNGVIVEKGKHETLINIKDGVYASLVQ 1285
Score = 314 bits (805), Expect = 9e-84
Identities = 204/626 (32%), Positives = 336/626 (53%), Gaps = 22/626 (3%)
Frame = -1
Query: 1842 EISHQKIDQEDDYVKKLIAEIKEEGAKKSN-------------ICEIIKYCRS-EYCILF 1705
E S+ KI +ED+ K +++KEE K ++ + S + ++
Sbjct: 22 ETSNSKIHEEDEKELKTESDLKEEKKKTEKNKQEEDEKTKTVPFHKLFAFADSFDIILMI 81
Query: 1704 IAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKD--EMLSKSHFWALSILFLAFTRPIFIFF 1531
+ +G+ G+ +P+ + L + + +++ ++ K AL ++L +
Sbjct: 82 LGTIGAVGNGLGFPIMTILFGDVIDVFGQNQNSSDVSDKIAKVALKFVYLGLGTLVAALL 141
Query: 1530 QYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDR 1351
Q + + E+ + ++RS+ + ++ AF+D +T + R++ D+ + A+ ++
Sbjct: 142 QVSGWMISGERQAGRIRSLYLQTILRQDIAFFDVETNTG-EVVGRMSGDTVLIQDAMGEK 200
Query: 1350 LGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEK 1171
+G I + + +++F W ++L ++ PLL ++G + + ++ K
Sbjct: 201 VGKAIQLVSTFIGGFVIAFTEGWLLTLVMVSSIPLLVMSGAALAIVISKMASRGQTSYAK 260
Query: 1170 SNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACS----C 1003
+ + + ++RTV + E + I HL S ++ V +G + G
Sbjct: 261 AAVVVEQTVGSIRTVASFTGEKQAISNYNKHLV----SAYRAGVFEGASTGLGLGTLNIV 316
Query: 1002 YFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLI 823
F YA++ +G ++L + +++ + + G A L AA +
Sbjct: 317 IFCTYALAVWYGGKMILEKGYTGGQVLIIIFAVLTGSMSLGQASPCLSAFAAGQAAAYKM 376
Query: 822 FH-LFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLAL 646
F + P I D++ + G+IEL NV+F Y R ++ I G SL + +G T+AL
Sbjct: 377 FEAIKRKPEIDASDTTGKVLDDIRGDIELNNVNFSYPARPEEQIFRGFSLSISSGSTVAL 436
Query: 645 VGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIK 466
VG SGSGKST++SL+ERFY GEV+ID N+ + L +R + LVSQEPVLF SIK
Sbjct: 437 VGQSGSGKSTVVSLIERFYDPQSGEVRIDGINLKEFQLKWIRSKIGLVSQEPVLFTSSIK 496
Query: 465 ENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARA 286
EN +G NA+ EI +A ++ANA F+ + PQGLDT+VGE G QLSGGQKQRIA+ARA
Sbjct: 497 ENIAYG-KENATVEEIRKATELANASKFIDKLPQGLDTMVGEHGTQLSGGQKQRIAVARA 555
Query: 285 ILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNG 106
IL++P++LLLDEATSALD++SE++VQ ALD +TVVVAHRLSTV NAD IAV+ G
Sbjct: 556 ILKDPRILLLDEATSALDAESERIVQEALDRIMVNRTTVVVAHRLSTVRNADMIAVIHQG 615
Query: 105 KVAEQGTHEELLR-KRSIYWRLVQKQ 31
K+ E+G+H ELLR Y +L++ Q
Sbjct: 616 KIVEKGSHSELLRDPEGAYSQLIRLQ 641
>gi|12585141|sp|Q9N0V3|AB11_RABIT Bile salt export pump (ATP-binding
cassette, sub-family B, member 11) (Sister of
P-glycoprotein)
gi|7644354|gb|AAF65552.1| liver bile salt export pump [Oryctolagus
cuniculus]
Length = 1321
Score = 662 bits (1708), Expect = 0.0
Identities = 422/1196 (35%), Positives = 647/1196 (53%), Gaps = 45/1196 (3%)
Frame = -1
Query: 3492 ESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMS 3313
ES+M R + +G A T G++Q + +R+ Y +++R I + D S
Sbjct: 135 ESEMIRFAGYYAGIGIAVLTTGYIQICFWGIAAAHQIQKMRKSYFRKIMRMGIGWVDCNS 194
Query: 3312 TGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVL 3133
G L+ + + + + +++A+ I +T + G ++ F W+L S I L
Sbjct: 195 VGKLNTPFSVDFNKINDSSADQLAIFIQGMTSPIFGFLVGFSQWWKLTLVIISVSPLIGL 254
Query: 3132 SGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKY 2953
+ K + + + + AGS+A + + +TV++ G+++EVERY + L +++
Sbjct: 255 GAAIIGLSVSKFTDYELKAYAKAGSVADEVISSMRTVAAFGGEKKEVERYEKNLVFAQRW 314
Query: 2952 ALNRAFVFSLSRSADY---FFTNALNFVILYFGANMIYE-GTIEPGVVVRILYYILFGSY 2785
+ + V + FF AL F ++G+ ++ E G PG +V+I ++ G+
Sbjct: 315 GIRKGIVMGFFTGYMWCLIFFCYALAF---WYGSKLVLEEGEYSPGALVQIFLSVIIGAL 371
Query: 2784 CLG------EAILHISRLASAIPLTV---PIADILLDSDATADEFFSEEIKDTFQGIISF 2632
LG EA AS+I T+ PI D + + D + E IK G I F
Sbjct: 372 NLGNASPCLEAFAAGRAAASSIFETIDRKPIIDCMSE-----DGYKLERIK----GEIEF 422
Query: 2631 KNVLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISID 2452
NV F YP+RP+V +L +S ++ GE ALVG SG+GKST +QL+ +Y G ++++
Sbjct: 423 HNVTFHYPSRPEVKILNNLSMVIKPGEMTALVGPSGAGKSTALQLIHRFYGPTEGMVTVE 482
Query: 2451 GNDIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVC 2272
+DI + +I+ LR +G+V QEPVLF +I E IR+G+ DAT +++I A K ANA++F+
Sbjct: 483 SHDIRSSHIQWLRNQIGIVEQEPVLFFHTIAEKIRYGREDATMEDLIQAAKEANAYNFIM 542
Query: 2271 NFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQ 2092
+ P T+VGE G Q+SGGQKQR+AIAR L+RNP+ILLLD ATSALDNESE +VQEAL
Sbjct: 543 DLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEALS 602
Query: 2091 KASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTN 1912
K G T + VAHR +TIR A+ II E G VE G ++L+ GVY LV Q N
Sbjct: 603 KTQHGHTIVSVAHRPATIRTADVIIGCEHGAAVERGTEEELLERKGVYFALVTLQ-SQRN 661
Query: 1911 YEKMNENEERVT----------------------RQSSHSDF-------PSNEISHQKID 1819
ENE+ T RQ S S P H+
Sbjct: 662 QGDQEENEKDATEDDIPEKTFSRGNYQDSLRASLRQRSKSQLSYLAHEPPMAVEDHKSTH 721
Query: 1818 QEDDYVKKLIAEIKEEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIK 1639
+ED K L A +E + +++ I+K E+ + + +G+A+ G PL + L +
Sbjct: 722 EEDRKDKDLPA---QEDIEPASVRRIMKLNAPEWPYMLLGSMGAAVNGAVTPLYAFLFSQ 778
Query: 1638 SYEAYAF-DKDEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKH 1462
++ DK+E S+ + L + L F Q Y F K+ E L+ +LR F+
Sbjct: 779 ILGTFSLPDKEEQRSQINGICLLFVTLGCVSFFTQFLQGYTFAKSGELLTKRLRKFGFRA 838
Query: 1461 LMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSW 1282
++ ++DD ++ L+ RL D+S V A ++G ++ + + +A+I++F +SW
Sbjct: 839 MLGQDIGWFDDLRNSPGALTTRLATDASQVQGATGSQIGMMVNSFTNVTVAMIIAFLFSW 898
Query: 1281 KMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENR 1102
K++L ++ F P L L+G + D A EK+ + EAL N+RTV + E +
Sbjct: 899 KLTLGIVCFFPFLALSGALQTKMLTGFASRDKQALEKAGQITSEALSNIRTVAGIGKERK 958
Query: 1101 VILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTY 922
I + L+K K+A + G GF+ F + S+++G +L+ E + +
Sbjct: 959 FIETFEAELEKPYKMAIKKANVYGLCFGFSQCITFIANSASYRYGGYLISNEGLHFSYVF 1018
Query: 921 LVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFHLF-TYPAIMPYDSSQGKRNIKNGEI 745
V+ + ++A+ G A +Y P + KA +A F L P I Y S+ K + G+I
Sbjct: 1019 RVISAVVLSATALGRASSYTPSYAKAKISAARFFQLLDRQPPINVYSSAGEKWDNFQGKI 1078
Query: 744 ELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVK 565
+ + F Y R D +L+G+S+ + +TLA VG SG GKST I LLERFY G+V
Sbjct: 1079 DFVDCKFTYPSRPDIQVLNGLSVSMSPRQTLAFVGSSGCGKSTSIQLLERFYDPDHGKVM 1138
Query: 564 IDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLE-IDQALKVANAF 388
ID + VN+ LR ++ +VSQEPVLF CSIK+N +G + +E I A K A
Sbjct: 1139 IDGHDSRKVNIQFLRSNIGIVSQEPVLFACSIKDNIKYGDNTQEIPMERIIAAAKKAQVH 1198
Query: 387 SFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQ 208
FV P+ +T VG +G+QLS G+KQRIAIARAI+R+PK+LLLDEATSALD++SEK VQ
Sbjct: 1199 DFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQ 1258
Query: 207 NALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLV 40
ALD A E + +V+AHRLST+ N+D IAV+ G V E+GTHEEL+ ++ Y++LV
Sbjct: 1259 VALDKAREGRTCIVIAHRLSTIQNSDIIAVMSQGMVIEKGTHEELMVQKGAYYKLV 1314
Score = 302 bits (773), Expect = 5e-80
Identities = 191/525 (36%), Positives = 288/525 (54%), Gaps = 5/525 (0%)
Frame = -1
Query: 3489 SDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGM-- 3316
S +N + LLF +G F FLQ G+ +R+ +L +DI +FD +
Sbjct: 793 SQINGICLLFVTLGCVSFFTQFLQGYTFAKSGELLTKRLRKFGFRAMLGQDIGWFDDLRN 852
Query: 3315 STGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIV 3136
S G L+ L + + + +I +++ T+ + I+AF W+L F +
Sbjct: 853 SPGALTTRLATDASQVQGATGSQIGMMVNSFTNVTVAMIIAFLFSWKLTLGIVCFFPFLA 912
Query: 3135 LSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEK 2956
LSG L + + + + AG I +AL +TV+ + +++ +E + EL+ K
Sbjct: 913 LSGALQTKMLTGFASRDKQALEKAGQITSEALSNIRTVAGIGKERKFIETFEAELEKPYK 972
Query: 2955 YALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLG 2776
A+ +A V+ L T N +G +I + V R++ ++ + LG
Sbjct: 973 MAIKKANVYGLCFGFSQCITFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALG 1032
Query: 2775 EAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPTRP 2599
A + A A ++ LLD + + S K D FQG I F + F+YP+RP
Sbjct: 1033 RASSYTPSYAKA-KISAARFFQLLDRQPPINVYSSAGEKWDNFQGKIDFVDCKFTYPSRP 1091
Query: 2598 DVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQ 2419
D+ VL +S ++ + +A VG+SG GKST IQLL +Y+ D G++ IDG+D +NI+
Sbjct: 1092 DIQVLNGLSVSMSPRQTLAFVGSSGCGKSTSIQLLERFYDPDHGKVMIDGHDSRKVNIQF 1151
Query: 2418 LRQAMGVVFQEPVLFNTSIEENIRFGK--PDATEQEIIDALKNANAFDFVCNFPDGIKTI 2245
LR +G+V QEPVLF SI++NI++G + + II A K A DFV + P+ +T
Sbjct: 1152 LRSNIGIVSQEPVLFACSIKDNIKYGDNTQEIPMERIIAAAKKAQVHDFVMSLPEKYETN 1211
Query: 2244 VGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTI 2065
VG +G+QLS G+KQRIAIAR +VR+P+ILLLDEATSALD ESE VQ AL KA GRT I
Sbjct: 1212 VGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCI 1271
Query: 2064 VVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQT 1930
V+AHRLSTI+N++ I VM +G ++E G H++L+ G Y LV T
Sbjct: 1272 VIAHRLSTIQNSDIIAVMSQGMVIEKGTHEELMVQKGAYYKLVTT 1316
Score = 281 bits (719), Expect = 9e-74
Identities = 172/504 (34%), Positives = 271/504 (53%), Gaps = 2/504 (0%)
Frame = -1
Query: 1536 FFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVD 1357
+ Q F+G A K+R F+ +M + + D C++ +L+ + D + + +
Sbjct: 157 YIQICFWGIAAAHQIQKMRKSYFRKIMRMGIGWVD--CNSVGKLNTPFSVDFNKINDSSA 214
Query: 1356 DRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAF 1177
D+L I + + + ++ F WK++L ++ PL+ L V + + + A+
Sbjct: 215 DQLAIFIQGMTSPIFGFLVGFSQWWKLTLVIISVSPLIGLGAAIIGLSVSKFTDYELKAY 274
Query: 1176 EKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYF 997
K+ A E + ++RTV A E + + +L + ++ ++ G G+ F
Sbjct: 275 AKAGSVADEVISSMRTVAAFGGEKKEVERYEKNLVFAQRWGIRKGIVMGFFTGYMWCLIF 334
Query: 996 FIYAVSFKFGTWLVLRE-EILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIF 820
F YA++F +G+ LVL E E P + +++ + A G+A L AA IF
Sbjct: 335 FCYALAFWYGSKLVLEEGEYSPGALVQIFLSVIIGALNLGNASPCLEAFAAGRAAASSIF 394
Query: 819 HLFTYPAIMPYDSSQG-KRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALV 643
I+ S G K GEIE NV+F Y R + IL+ +S+ + G ALV
Sbjct: 395 ETIDRKPIIDCMSEDGYKLERIKGEIEFHNVTFHYPSRPEVKILNNLSMVIKPGEMTALV 454
Query: 642 GPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKE 463
GPSG+GKST + L+ RFY +G V ++ ++ ++ LR + +V QEPVLF +I E
Sbjct: 455 GPSGAGKSTALQLIHRFYGPTEGMVTVESHDIRSSHIQWLRNQIGIVEQEPVLFFHTIAE 514
Query: 462 NFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAI 283
+G +A+ ++ QA K ANA++F+ PQ DTLVGE G Q+SGGQKQR+AIARA+
Sbjct: 515 KIRYG-REDATMEDLIQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARAL 573
Query: 282 LRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGK 103
+RNPK+LLLD ATSALD++SE +VQ AL + V VAHR +T+ AD I ++G
Sbjct: 574 IRNPKILLLDMATSALDNESEAMVQEALSKTQHGHTIVSVAHRPATIRTADVIIGCEHGA 633
Query: 102 VAEQGTHEELLRKRSIYWRLVQKQ 31
E+GT EELL ++ +Y+ LV Q
Sbjct: 634 AVERGTEEELLERKGVYFALVTLQ 657
>gi|25297456|pir||F86155 probable ABC transporter [imported] -
Arabidopsis thaliana
gi|9972377|gb|AAG10627.1| Putative ABC transporter [Arabidopsis
thaliana]
Length = 1229
Score = 660 bits (1704), Expect = 0.0
Identities = 416/1241 (33%), Positives = 659/1241 (52%), Gaps = 39/1241 (3%)
Frame = -1
Query: 3642 GVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFESDMNRVVLL 3463
G + +I G+C P + G+ K N D VD+ +++V L
Sbjct: 4 GSLGAIGNGVCLPLMTLLFGDLIDSFGK-----NQNNKDIVDV----------VSKVCLK 48
Query: 3462 FFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFD-GMSTGHLSIVLN 3286
F +G FLQ + G+ A +R Y+ +LR+DI +FD +TG + ++
Sbjct: 49 FVYLGLGRLGAAFLQVACWMITGERQAAKIRSNYLKTILRQDIGFFDVETNTGEVVGRMS 108
Query: 3285 DNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLLDSWGK 3106
+ ++ EK+ I L++ FV G LAF W L + ++G +
Sbjct: 109 GDTVHIQDAMGEKVGKFIQLVSTFVGGFALAFAKGWLLTLVMLTSIPFLAMAGAAMALLV 168
Query: 3105 MKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNRAFVFS 2926
+ + + + A ++ Q +G +TV+S G++Q + Y + + + K ++ + F
Sbjct: 169 TRASSRGQAAYAKAATVVEQTIGSIRTVASFTGEKQAINSYKKYITSAYKSSIQQGFSTG 228
Query: 2925 LSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEAILHISRLA 2746
L + + + ++FG MI E G V+ ++ ++ GS LG+ ++ A
Sbjct: 229 LGLGVMIYVFFSSYALAIWFGGKMILEKGYTGGSVINVIIIVVAGSMSLGQTSPCVTAFA 288
Query: 2745 SAIPLTVPIADILLDSDATADEFFSEEIKDTFQGIISFKNVLFSYPTRPDVPVLKEISFN 2566
+ + + + + ++ +G I K+V FSYP RPD + S
Sbjct: 289 AGQAAAYKMFETIKRKPLIDAYDVNGKVLGDIRGDIELKDVHFSYPARPDEEIFDGFSLF 348
Query: 2565 VQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAMGVVFQE 2386
+ G ALVG SGSGKSTVI L+ +Y+ +G + IDG ++ +K +R +G+V QE
Sbjct: 349 IPSGATAALVGESGSGKSTVINLIERFYDPKAGEVLIDGINLKEFQLKWIRSKIGLVCQE 408
Query: 2385 PVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGERGAQLSGGQK 2206
PVLF++SI ENI +GK +AT QEI A + ANA F+ N P G+ T VGE G QLSGGQK
Sbjct: 409 PVLFSSSIMENIAYGKENATLQEIKVATELANAAKFINNLPQGLDTKVGEHGTQLSGGQK 468
Query: 2205 QRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHRLSTIRNAN 2026
QRIAIAR ++++PR+LLLDEATSALD ESE +VQEAL + + RTT+VVAHRLST+RNA+
Sbjct: 469 QRIAIARAILKDPRVLLLDEATSALDTESERVVQEALDRVMVNRTTVVVAHRLSTVRNAD 528
Query: 2025 KIIVMEKGEIVEVGDHKQLIAMN-GVYNNLVQTQLMSTNYE---------------KMNE 1894
I V+ G++VE G H +L+ + G Y+ L++ Q ++ ++ +N
Sbjct: 529 MIAVIHSGKMVEKGSHSELLKDSVGAYSQLIRCQEINKGHDAKPSDMASGSSFRNSNLNI 588
Query: 1893 NEERVTRQSSHSDFPSNEISH-----------------QKIDQEDDYVKKLIAEIKEEGA 1765
+ E S F ++ H Q++ QE+ +E
Sbjct: 589 SREGSVISGGTSSFGNSSRHHSLNVLGLFAGLDLGSGSQRVGQEE------TGTTSQEPL 642
Query: 1764 KKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHF 1585
+K ++ I + E +L + + +AI G +PL L+ + EA+ D++ S F
Sbjct: 643 RKVSLTRIAALNKPEIPVLLLGTVVAAINGAIFPLFGILISRVIEAFFKPADQLKKDSRF 702
Query: 1584 WALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRL 1405
WA+ + L T I Q Y F KL +++SM F+ + + +++D+P +++ +
Sbjct: 703 WAIIFVALGVTSLIVSPSQMYLFAVAGGKLIRRIQSMCFEKAVHMEVSWFDEPENSSGTM 762
Query: 1404 SNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYC 1225
RL+ D++ + A V D L + + +I++F SW+++L +L+ PL+ + G+
Sbjct: 763 GARLSTDAALIRALVGDALSLAVQNAASAASGLIIAFTASWELALIILVMLPLIGINGFL 822
Query: 1224 NDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKR 1045
F+ + +E++++ A +A+ ++RTV + E +V+ + + K+
Sbjct: 823 QVKFMKGFSADAKSKYEEASQVANDAVGSIRTVASFCAEEKVMQMYNKQCEGPIKDGVKQ 882
Query: 1044 AVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAY 865
I G GF+ F +YA SF LV + +D + V L+M A + +
Sbjct: 883 GFISGLGFGFSFFILFCVYATSFYAAARLVEDGKTTFIDVFQVFFALTMAAIGISQSSTF 942
Query: 864 LPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGK--RNIKNGEIELKNVSFEYAQRSDKMIL 691
PD KA AA IF + + + G N+K G+IEL+++SF Y R I
Sbjct: 943 APDSSKAKVAAASIFAIIDRKSKIDSSDETGTVLENVK-GDIELRHLSFTYPARPGIQIF 1001
Query: 690 DGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESV 511
+ L + AG+T+ALVG SGSGKST+ISLL+RFY G++ +D + + L LR+ +
Sbjct: 1002 RDLCLTIRAGKTVALVGESGSGKSTVISLLQRFYDPDSGQITLDGVELKKLQLKWLRQQM 1061
Query: 510 SLVSQEPVLFNCSIKENFLF--GISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGER 337
LV QEPVLFN +I+ N + G A++ EI A ++ANA F+S QG DT+VGE+
Sbjct: 1062 GLVGQEPVLFNDTIRANIAYGKGSEEAATESEIIAAAELANAHKFISSIQQGYDTVVGEK 1121
Query: 336 GAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAH 157
G QLSGGQKQR+AIARAI++ PK+LLLDEATSALD++SE++VQ+ALD +TVVVAH
Sbjct: 1122 GIQLSGGQKQRVAIARAIVKEPKILLLDEATSALDAESERLVQDALDRVIVNRTTVVVAH 1181
Query: 156 RLSTVVNADSIAVLKNGKVAEQGTHEELLR-KRSIYWRLVQ 37
RLST+ NAD IA++KNG +AE GTHE L++ +Y LVQ
Sbjct: 1182 RLSTIKNADVIAIVKNGVIAENGTHETLIKIDGGVYASLVQ 1222
>gi|34911450|ref|NP_917072.1| putative multidrug resistance protein 1
homolog [Oryza sativa (japonica cultivar-group)]
gi|22535536|dbj|BAC10713.1| putative multidrug resistance protein 1
homolog [Oryza sativa (japonica cultivar-group)]
Length = 1265
Score = 660 bits (1702), Expect = 0.0
Identities = 400/1151 (34%), Positives = 628/1151 (53%), Gaps = 33/1151 (2%)
Frame = -1
Query: 3420 QFSIMKFVGDNTAYNVRRQYISRLLRKDISYFD-GMSTGHLSIVLNDNMERFREVFNEKI 3244
Q S G+ + +R Y+ ++ +DI++FD M+TG + ++ + ++ EK+
Sbjct: 106 QVSCWTMAGERQSACIRSLYLEAIITQDIAFFDVEMTTGEAASRISADTVLIQDALGEKV 165
Query: 3243 ALIIALLTDFVIGTILAFYTDWRLACY------GTVFSFGIVLSGLLDSWGKMKNNEKQN 3082
I +LT FV G ++ F W LA ++FSF +V S + + + K +
Sbjct: 166 GKYIQVLTAFVGGFVIGFIRGWMLALVVMACIPPSIFSFALV------SRLRAQISGKTH 219
Query: 3081 EHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNRAFVFSLSRSADYF 2902
S AG++ Q +G + V S NG+++ + Y +K K + + + +F
Sbjct: 220 VSYSYAGNVVEQTIGSIRMVVSFNGEKRAITMYNTLIKKAYKATIMEGIISGFGIGSIFF 279
Query: 2901 FTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEAILHISRLASAIPLTVP 2722
+ ++GA ++ G V+ +++ IL GS +G A IS +A
Sbjct: 280 VVYCSYSLAFWYGAKLVISKGYTGGQVINVVFAILTGSMAIGNASPSISAIAEGQSAAHR 339
Query: 2721 IADILLDSDATADEFFSEEIKDTFQGIISFKNVLFSYPTRPDVPVLKEISFNVQGGECIA 2542
+ +I+ S I + +G + K+V FSYP RP+ +L + V G +A
Sbjct: 340 LFEIINRKPNIDITGTSGIILEDIKGNVELKDVCFSYPARPEQLILDGLCLQVPNGTTMA 399
Query: 2541 LVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAMGVVFQEPVLFNTSI 2362
+VG SGSGKST+I L+ +Y+ G + IDG +I + + +R M +V QEP+LF TSI
Sbjct: 400 IVGQSGSGKSTIISLVERFYDPQDGEVLIDGINIKTLKLHWIRGKMSLVSQEPLLFMTSI 459
Query: 2361 EENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGERGAQLSGGQKQRIAIART 2182
++NI +GK +AT++EI A + ANA +F+ P+ T+VG+ GAQLSGGQKQRIAIAR
Sbjct: 460 KDNITYGKENATDEEIKRAAELANAANFIDKLPNAYDTMVGQHGAQLSGGQKQRIAIARA 519
Query: 2181 LVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHRLSTIRNANKIIVMEKG 2002
+++NP++LLLDEATSALD ESE +VQEAL + IGRTT++VAHRLSTI+NA+ I V+ +G
Sbjct: 520 ILKNPKVLLLDEATSALDVESERLVQEALNRVMIGRTTLIVAHRLSTIKNADCIAVVHQG 579
Query: 2001 EIVEVGDHKQLIA-MNGVYNNLVQTQLMSTNYEKMNE---NEERVTRQSSHS-------- 1858
+IV+ G H +LI +G Y+ L+Q Q T+ E+M++ +E +R S S
Sbjct: 580 KIVDQGSHDELIKDPDGAYSQLIQLQ--QTHTEEMHDVQYSEVSTSRLKSRSLSLEQSMI 637
Query: 1857 -DFPSNE-----ISHQKIDQEDDYVKKLIAEIKEE-------GAKKSNICEIIKYCRSEY 1717
D P N H D K + + E+ K+ I + + E
Sbjct: 638 NDSPRNRRKNSLAKHIGSSGSDGLHKHGLTDEPEDKECGDNKDINKAPIRRLFNLNKPEA 697
Query: 1716 CILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWALSILFLAFTRPIFI 1537
IL +A++ + + G+ +P+ S +M + + ++ S FWAL + +A + I
Sbjct: 698 PILLLAIITAFVHGLLFPIFSIMMSGGIRTFYYPPHQLRKDSRFWALMCILMAIISLVSI 757
Query: 1536 FFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVD 1357
+Y+ FG KL ++R +SF+ ++ +++DDP H++ L +L D+ N+ V
Sbjct: 758 QLEYFLFGMAGGKLIERVRCLSFQSIVHQEVSWFDDPSHSSGSLGAKLYIDALNIRRLVG 817
Query: 1356 DRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAF 1177
D L ++ +V ++ ++F WK++L ++ PL+ L Y F+ E+ + +
Sbjct: 818 DNLAILVQCIVTLIAGFTIAFASDWKLTLTIMCPIPLVGLQNYVQLKFLKGFSEDAKVMY 877
Query: 1176 EKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYF 997
E +++ EA+ ++RTV + E RVI Q + ++ G F+ +
Sbjct: 878 EDASQVVTEAIGSIRTVASFCAEKRVIKTYNQKCQASMKESIRSGMVGGLGFSFSYLMVY 937
Query: 996 FIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFH 817
YA+ F G V + D + V L TA A D KA +A I
Sbjct: 938 LTYALCFYVGAQFVHGGKSTFKDVFRVYFALVFTAFGISQTSAMASDSSKAHESAASILA 997
Query: 816 LFTYPAIMPYDSSQGKRNIK-NGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVG 640
+ + + +G K NG IEL +V+F+Y R D +L +L +P+G+T+ALVG
Sbjct: 998 IIDRKSNIDSSIDEGIILEKVNGTIELNHVNFKYPSRPDVQVLCDFTLGIPSGKTVALVG 1057
Query: 639 PSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKEN 460
SGSGKST+I+LLERFY G + +D + ++ L LR+ + LVSQEP+LFN +I N
Sbjct: 1058 ESGSGKSTVIALLERFYDPHSGTISLDRVELKNLKLSWLRDQMGLVSQEPILFNDTIHAN 1117
Query: 459 FLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAIL 280
+G ++ EI K +NA F+S PQG +T VGERG QLSGGQKQRIAIARAIL
Sbjct: 1118 IAYGRKGQVTEEEIIAVAKASNAHEFISSLPQGYNTTVGERGTQLSGGQKQRIAIARAIL 1177
Query: 279 RNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKV 100
++PK+LLLDEATSALD++SE++VQ+ALD +T+VVAHRLST+ AD IAV+K+G +
Sbjct: 1178 KDPKILLLDEATSALDAESERIVQDALDQVMVSRTTIVVAHRLSTIKGADVIAVIKDGSI 1237
Query: 99 AEQGTHEELLR 67
AE+G H+ L+R
Sbjct: 1238 AEKGQHDSLMR 1248
Score = 295 bits (755), Expect = 6e-78
Identities = 184/512 (35%), Positives = 281/512 (53%), Gaps = 9/512 (1%)
Frame = -1
Query: 3423 LQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFD--GMSTGHLSIVLNDNMERFREVFNE 3250
L++ + G VR ++ +++S+FD S+G L L + R + +
Sbjct: 759 LEYFLFGMAGGKLIERVRCLSFQSIVHQEVSWFDDPSHSSGSLGAKLYIDALNIRRLVGD 818
Query: 3249 KIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLLDSWGKMKN----NEKQN 3082
+A+++ + + G +AF +DW+L I L GL ++ ++K +E
Sbjct: 819 NLAILVQCIVTLIAGFTIAFASDWKLTL---TIMCPIPLVGL-QNYVQLKFLKGFSEDAK 874
Query: 3081 EHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNRAFVFSLSRSADYF 2902
+A + +A+G +TV+S +++ ++ Y ++ + K ++ V L S Y
Sbjct: 875 VMYEDASQVVTEAIGSIRTVASFCAEKRVIKTYNQKCQASMKESIRSGMVGGLGFSFSYL 934
Query: 2901 FTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEAILHISRLASAIPLTVP 2722
+ Y GA ++ G V R+ + ++F ++ + + S + A
Sbjct: 935 MVYLTYALCFYVGAQFVHGGKSTFKDVFRVYFALVFTAFGISQTSAMASDSSKAHESAAS 994
Query: 2721 IADILLDSDATADEFFSEEI-KDTFQGIISFKNVLFSYPTRPDVPVLKEISFNVQGGECI 2545
I I+ D + D E I + G I +V F YP+RPDV VL + + + G+ +
Sbjct: 995 ILAII-DRKSNIDSSIDEGIILEKVNGTIELNHVNFKYPSRPDVQVLCDFTLGIPSGKTV 1053
Query: 2544 ALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAMGVVFQEPVLFNTS 2365
ALVG SGSGKSTVI LL +Y+ SG IS+D ++ N+ + LR MG+V QEP+LFN +
Sbjct: 1054 ALVGESGSGKSTVIALLERFYDPHSGTISLDRVELKNLKLSWLRDQMGLVSQEPILFNDT 1113
Query: 2364 IEENIRFG-KPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGERGAQLSGGQKQRIAIA 2188
I NI +G K TE+EII K +NA +F+ + P G T VGERG QLSGGQKQRIAIA
Sbjct: 1114 IHANIAYGRKGQVTEEEIIAVAKASNAHEFISSLPQGYNTTVGERGTQLSGGQKQRIAIA 1173
Query: 2187 RTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHRLSTIRNANKIIVME 2008
R ++++P+ILLLDEATSALD ESE IVQ+AL + + RTTIVVAHRLSTI+ A+ I V++
Sbjct: 1174 RAILKDPKILLLDEATSALDAESERIVQDALDQVMVSRTTIVVAHRLSTIKGADVIAVIK 1233
Query: 2007 KGEIVEVGDHKQLIAMN-GVYNNLVQTQLMST 1915
G I E G H L+ +N GVY +LV +T
Sbjct: 1234 DGSIAEKGQHDSLMRINGGVYASLVDLHSKTT 1265
>gi|25407562|pir||H85202 hypothetical protein AT4g18050 [imported] -
Arabidopsis thaliana
gi|7268557|emb|CAB78807.1| multidrug resistance
protein/P-glycoprotein-like [Arabidopsis thaliana]
Length = 1323
Score = 659 bits (1700), Expect = 0.0
Identities = 433/1271 (34%), Positives = 671/1271 (52%), Gaps = 61/1271 (4%)
Frame = -1
Query: 3702 KTFGFQIKCTTRYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDP 3523
K F F K + +L +G + + G+ QPF + G+ + NA T DP
Sbjct: 20 KLFSFADKT----DVVLMTVGTIAAAGNGLTQPFMTLIFGQ-------LINAFG--TTDP 66
Query: 3522 VDLAHAYKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLR 3343
+ ++ +V + F + FLQ S G+ + +R Y+ +LR
Sbjct: 67 DHMVR-------EVWKVAVKFIYLAVYSCVVAFLQVSCWMVTGERQSATIRGLYLKTILR 119
Query: 3342 KDISYFDG-MSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLAC 3166
+DI YFD +TG + ++ + ++ EK+ LL F+ G +AFY LA
Sbjct: 120 QDIGYFDTETNTGEVIGRMSGDTILIQDAMGEKVGKFTQLLCTFLGGFAIAFYKGPLLAG 179
Query: 3165 YGTVFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVER 2986
IV++G S K + + AG++ Q +G +TV + G++Q E+
Sbjct: 180 VLCSCIPLIVIAGAAMSLIMSKMAGRGQVAYAEAGNVVEQTVGAIRTVVAFTGEKQATEK 239
Query: 2985 YTEELKNGEKYALNRAFV--FSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRI 2812
Y +L+ K + + + F L F + + +++GA +I E G V+ +
Sbjct: 240 YESKLEIAYKTVVQQGLISGFGLGTMLAVIFCSY--GLAVWYGAKLIMEKGYNGGQVINV 297
Query: 2811 LYYILFGSYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIKDTFQGIISF 2632
++ +L G LG+ ++ A+ + + + S S + + +G I
Sbjct: 298 IFAVLTGGMSLGQTSPSLNAFAAGRAAAFKMFETIKRSPKIDAYDMSGSVLEDIRGDIEL 357
Query: 2631 KNVLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISID 2452
K+V F YP RPDV + S V G+ +ALVG SGSGKSTVI L+ +Y+ +SG++ ID
Sbjct: 358 KDVYFRYPARPDVQIFAGFSLFVPNGKTVALVGQSGSGKSTVISLIERFYDPESGQVLID 417
Query: 2451 GNDIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVC 2272
D+ + +K +R +G+V QEPVLF T+I+ENI +GK DAT+QEI A++ ANA F+
Sbjct: 418 NIDLKKLQLKWIRSKIGLVSQEPVLFATTIKENIAYGKEDATDQEIRTAIELANAAKFID 477
Query: 2271 NFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQ 2092
P G+ T+VGE G Q+SGGQKQR+AIAR +++NP+ILLLDEATSALD ESE IVQ+AL
Sbjct: 478 KLPQGLDTMVGEHGTQMSGGQKQRLAIARAILKNPKILLLDEATSALDAESERIVQDALV 537
Query: 2091 KASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIA-MNGVYNNLVQTQLMST 1915
RTT+VVAHRL+TIR A+ I V+ +G+IVE G H ++I G Y+ LV+ Q S
Sbjct: 538 NLMSNRTTVVVAHRLTTIRTADVIAVVHQGKIVEKGTHDEMIQDPEGAYSQLVRLQEGSK 597
Query: 1914 NYEKMNENEE-------------------RVTRQSSHSDFPSNEISHQ-----KIDQEDD 1807
+E E V+R SS S + S+ ++Q D+
Sbjct: 598 EEATESERPETSLDVERSGSLRLSSAMRRSVSRNSSSSRHSFSLASNMFFPGVNVNQTDE 657
Query: 1806 YVKKLIAEIKEEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEA 1627
+ E KK ++ + + E +L + + + + G +P+ L+ S
Sbjct: 658 ----MEDEENNVRHKKVSLKRLAHLNKPEIPVLVLGSIAAMVHGTVFPIFGLLLSSSINM 713
Query: 1626 YAFDKDEMLSK-SHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSL 1450
+ ++ ++L K SHFWAL + L T + I YFFG KL ++RSM F ++
Sbjct: 714 F-YEPAKILKKDSHFWALIYIALGLTNFVMIPVPNYFFGIAGGKLIKRIRSMCFDKVVHQ 772
Query: 1449 PCAFYDDPCHT---------------------------ATRLSNRLNADSSNVTAAVDDR 1351
+++DD ++ RL + D+S V + V D
Sbjct: 773 EISWFDDTANSRYYNFIYIINRRILYVLILIFICVLLPPVRLERECSTDASTVRSLVGDA 832
Query: 1350 LGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEK 1171
L ++ + + +I++F +W ++L VL P + + GY F+ + +E+
Sbjct: 833 LALIVQNIATVTTGLIIAFTANWILALIVLALSPFIVIQGYAQTKFLTGFSADAKAMYEE 892
Query: 1170 SNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFI 991
+++ A +A+ ++RTV + E +V+ L + + + ++ G GF+ +FF+
Sbjct: 893 ASQVANDAVSSIRTVASFCAEEKVMDLYQQKCDGPKKNGVRLGLLSGAGFGFS---FFFL 949
Query: 990 YAVS---FKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIF 820
Y ++ F G L+ + + + V L++ A A PD KA +A IF
Sbjct: 950 YCINCVCFVSGAGLIQIGKATFGEVFKVFFALTIMAIGVSQTSAMAPDSNKAKDSAASIF 1009
Query: 819 HLFTYPAIMPYDSSQGK--RNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLAL 646
+ + S +G +N+ NG+IE ++VSF Y R D I + L +P+G+T+AL
Sbjct: 1010 DILDSTPKIDSSSDEGTTLQNV-NGDIEFRHVSFRYPMRPDVQIFRDLCLTIPSGKTVAL 1068
Query: 645 VGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIK 466
VG SGSGKST+IS++ERFY+ G++ ID+ + L LR+ + LVSQEP+LFN +I+
Sbjct: 1069 VGESGSGKSTVISMIERFYNPDSGKILIDQVEIQTFKLSWLRQQMGLVSQEPILFNETIR 1128
Query: 465 ENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARA 286
N +G + A++ EI A K ANA +F+S PQG DT VGERG QLSGGQKQRIAIARA
Sbjct: 1129 SNIAYGKTGGATEEEIIAAAKAANAHNFISSLPQGYDTSVGERGVQLSGGQKQRIAIARA 1188
Query: 285 ILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNG 106
IL++PK+LLLDEATSALD++SE+VVQ+ALD +TVVVAHRL+T+ NAD IAV+KNG
Sbjct: 1189 ILKDPKILLLDEATSALDAESERVVQDALDRVMVNRTTVVVAHRLTTIKNADVIAVVKNG 1248
Query: 105 KVAEQGTHEEL 73
+AE+G HE L
Sbjct: 1249 VIAEKGRHETL 1259
Score = 300 bits (768), Expect = 2e-79
Identities = 195/585 (33%), Positives = 311/585 (52%), Gaps = 5/585 (0%)
Frame = -1
Query: 1770 GAKKSNICEIIKYC-RSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAF-DKDEMLS 1597
G +K + ++ + +++ ++ + + +A G+ P + + + A+ D D M+
Sbjct: 12 GNQKVSFFKLFSFADKTDVVLMTVGTIAAAGNGLTQPFMTLIFGQLINAFGTTDPDHMVR 71
Query: 1596 KSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHT 1417
+ A+ ++LA + F Q + T E+ S +R + K ++ ++D +T
Sbjct: 72 EVWKVAVKFIYLAVYSCVVAFLQVSCWMVTGERQSATIRGLYLKTILRQDIGYFDTETNT 131
Query: 1416 ATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFC-PLLY 1240
+ R++ D+ + A+ +++G L L ++F Y + VL C PL+
Sbjct: 132 G-EVIGRMSGDTILIQDAMGEKVGKFTQLLCTFLGGFAIAF-YKGPLLAGVLCSCIPLIV 189
Query: 1239 LAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRN 1060
+AG + + +A+ ++ + + +RTV A E + S L+
Sbjct: 190 IAGAAMSLIMSKMAGRGQVAYAEAGNVVEQTVGAIRTVVAFTGEKQATEKYESKLEIAYK 249
Query: 1059 SYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAG 880
+ ++ +I G G + F Y ++ +G L++ + V+ + G
Sbjct: 250 TVVQQGLISGFGLGTMLAVIFCSYGLAVWYGAKLIMEKGYNGGQVINVIFAVLTGGMSLG 309
Query: 879 SAVAYLPDHRKAIHAAGLIFHLFTY-PAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSD 703
L AA +F P I YD S G+IELK+V F Y R D
Sbjct: 310 QTSPSLNAFAAGRAAAFKMFETIKRSPKIDAYDMSGSVLEDIRGDIELKDVYFRYPARPD 369
Query: 702 KMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHL 523
I G SL +P G+T+ALVG SGSGKST+ISL+ERFY G+V ID ++ + L +
Sbjct: 370 VQIFAGFSLFVPNGKTVALVGQSGSGKSTVISLIERFYDPESGQVLIDNIDLKKLQLKWI 429
Query: 522 RESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVG 343
R + LVSQEPVLF +IKEN +G +A+ EI A+++ANA F+ + PQGLDT+VG
Sbjct: 430 RSKIGLVSQEPVLFATTIKENIAYG-KEDATDQEIRTAIELANAAKFIDKLPQGLDTMVG 488
Query: 342 ERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVV 163
E G Q+SGGQKQR+AIARAIL+NPK+LLLDEATSALD++SE++VQ+AL +TVVV
Sbjct: 489 EHGTQMSGGQKQRLAIARAILKNPKILLLDEATSALDAESERIVQDALVNLMSNRTTVVV 548
Query: 162 AHRLSTVVNADSIAVLKNGKVAEQGTHEELLR-KRSIYWRLVQKQ 31
AHRL+T+ AD IAV+ GK+ E+GTH+E+++ Y +LV+ Q
Sbjct: 549 AHRLTTIRTADVIAVVHQGKIVEKGTHDEMIQDPEGAYSQLVRLQ 593
>gi|22328760|ref|NP_193539.2| ABC transporter family protein
[Arabidopsis thaliana]
Length = 1281
Score = 657 bits (1694), Expect = 0.0
Identities = 429/1244 (34%), Positives = 665/1244 (52%), Gaps = 34/1244 (2%)
Frame = -1
Query: 3702 KTFGFQIKCTTRYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDP 3523
K F F K + +L +G + + G+ QPF + G+ + NA T DP
Sbjct: 20 KLFSFADKT----DVVLMTVGTIAAAGNGLTQPFMTLIFGQ-------LINAFG--TTDP 66
Query: 3522 VDLAHAYKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLR 3343
+ ++ +V + F + FLQ S G+ + +R Y+ +LR
Sbjct: 67 DHMVR-------EVWKVAVKFIYLAVYSCVVAFLQVSCWMVTGERQSATIRGLYLKTILR 119
Query: 3342 KDISYFDG-MSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLAC 3166
+DI YFD +TG + ++ + ++ EK+ LL F+ G +AFY LA
Sbjct: 120 QDIGYFDTETNTGEVIGRMSGDTILIQDAMGEKVGKFTQLLCTFLGGFAIAFYKGPLLAG 179
Query: 3165 YGTVFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVER 2986
IV++G S K + + AG++ Q +G +TV + G++Q E+
Sbjct: 180 VLCSCIPLIVIAGAAMSLIMSKMAGRGQVAYAEAGNVVEQTVGAIRTVVAFTGEKQATEK 239
Query: 2985 YTEELKNGEKYALNRAFV--FSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRI 2812
Y +L+ K + + + F L F + + +++GA +I E G V+ +
Sbjct: 240 YESKLEIAYKTVVQQGLISGFGLGTMLAVIFCSY--GLAVWYGAKLIMEKGYNGGQVINV 297
Query: 2811 LYYILFGSYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIKDTFQGIISF 2632
++ +L G LG+ ++ A+ + + + S S + + +G I
Sbjct: 298 IFAVLTGGMSLGQTSPSLNAFAAGRAAAFKMFETIKRSPKIDAYDMSGSVLEDIRGDIEL 357
Query: 2631 KNVLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISID 2452
K+V F YP RPDV + S V G+ +ALVG SGSGKSTVI L+ +Y+ +SG++ ID
Sbjct: 358 KDVYFRYPARPDVQIFAGFSLFVPNGKTVALVGQSGSGKSTVISLIERFYDPESGQVLID 417
Query: 2451 GNDIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVC 2272
D+ + +K +R +G+V QEPVLF T+I+ENI +GK DAT+QEI A++ ANA F+
Sbjct: 418 NIDLKKLQLKWIRSKIGLVSQEPVLFATTIKENIAYGKEDATDQEIRTAIELANAAKFID 477
Query: 2271 NFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQ 2092
P G+ T+VGE G Q+SGGQKQR+AIAR +++NP+ILLLDEATSALD ESE IVQ+AL
Sbjct: 478 KLPQGLDTMVGEHGTQMSGGQKQRLAIARAILKNPKILLLDEATSALDAESERIVQDALV 537
Query: 2091 KASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIA-MNGVYNNLVQTQLMST 1915
RTT+VVAHRL+TIR A+ I V+ +G+IVE G H ++I G Y+ LV+ Q S
Sbjct: 538 NLMSNRTTVVVAHRLTTIRTADVIAVVHQGKIVEKGTHDEMIQDPEGAYSQLVRLQEGSK 597
Query: 1914 NYEKMNENEER-------------------VTRQSSHSDFPSNEISHQ-----KIDQEDD 1807
+E E V+R SS S + S+ ++Q D+
Sbjct: 598 EEATESERPETSLDVERSGSLRLSSAMRRSVSRNSSSSRHSFSLASNMFFPGVNVNQTDE 657
Query: 1806 YVKKLIAEIKEEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEA 1627
+ E KK ++ + + E +L + + + + G +P+ L+ S
Sbjct: 658 ----MEDEENNVRHKKVSLKRLAHLNKPEIPVLVLGSIAAMVHGTVFPIFGLLLSSSINM 713
Query: 1626 YAFDKDEMLSK-SHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSL 1450
+ ++ ++L K SHFWAL + L T + I YFFG KL ++RSM F ++
Sbjct: 714 F-YEPAKILKKDSHFWALIYIALGLTNFVMIPVPNYFFGIAGGKLIKRIRSMCFDKVVHQ 772
Query: 1449 PCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSL 1270
+++DD ++N + V D L ++ + + +I++F +W ++L
Sbjct: 773 EISWFDD---------------TANSRSLVGDALALIVQNIATVTTGLIIAFTANWILAL 817
Query: 1269 QVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILL 1090
VL P + + GY F+ + +E++++ A +A+ ++RTV + E +V+ L
Sbjct: 818 IVLALSPFIVIQGYAQTKFLTGFSADAKAMYEEASQVANDAVSSIRTVASFCAEEKVMDL 877
Query: 1089 VTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVS---FKFGTWLVLREEILPMDTYL 919
+ + + ++ G GF+ +FF+Y ++ F G L+ + + +
Sbjct: 878 YQQKCDGPKKNGVRLGLLSGAGFGFS---FFFLYCINCVCFVSGAGLIQIGKATFGEVFK 934
Query: 918 VLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGK--RNIKNGEI 745
V L++ A A PD KA +A IF + + S +G +N+ NG+I
Sbjct: 935 VFFALTIMAIGVSQTSAMAPDSNKAKDSAASIFDILDSTPKIDSSSDEGTTLQNV-NGDI 993
Query: 744 ELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVK 565
E ++VSF Y R D I + L +P+G+T+ALVG SGSGKST+IS++ERFY+ G++
Sbjct: 994 EFRHVSFRYPMRPDVQIFRDLCLTIPSGKTVALVGESGSGKSTVISMIERFYNPDSGKIL 1053
Query: 564 IDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFS 385
ID+ + L LR+ + LVSQEP+LFN +I+ N +G + A++ EI A K ANA +
Sbjct: 1054 IDQVEIQTFKLSWLRQQMGLVSQEPILFNETIRSNIAYGKTGGATEEEIIAAAKAANAHN 1113
Query: 384 FVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQN 205
F+S PQG DT VGERG QLSGGQKQRIAIARAIL++PK+LLLDEATSALD++SE+VVQ+
Sbjct: 1114 FISSLPQGYDTSVGERGVQLSGGQKQRIAIARAILKDPKILLLDEATSALDAESERVVQD 1173
Query: 204 ALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEEL 73
ALD +TVVVAHRL+T+ NAD IAV+KNG +AE+G HE L
Sbjct: 1174 ALDRVMVNRTTVVVAHRLTTIKNADVIAVVKNGVIAEKGRHETL 1217
Score = 300 bits (768), Expect = 2e-79
Identities = 195/585 (33%), Positives = 311/585 (52%), Gaps = 5/585 (0%)
Frame = -1
Query: 1770 GAKKSNICEIIKYC-RSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAF-DKDEMLS 1597
G +K + ++ + +++ ++ + + +A G+ P + + + A+ D D M+
Sbjct: 12 GNQKVSFFKLFSFADKTDVVLMTVGTIAAAGNGLTQPFMTLIFGQLINAFGTTDPDHMVR 71
Query: 1596 KSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHT 1417
+ A+ ++LA + F Q + T E+ S +R + K ++ ++D +T
Sbjct: 72 EVWKVAVKFIYLAVYSCVVAFLQVSCWMVTGERQSATIRGLYLKTILRQDIGYFDTETNT 131
Query: 1416 ATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFC-PLLY 1240
+ R++ D+ + A+ +++G L L ++F Y + VL C PL+
Sbjct: 132 G-EVIGRMSGDTILIQDAMGEKVGKFTQLLCTFLGGFAIAF-YKGPLLAGVLCSCIPLIV 189
Query: 1239 LAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRN 1060
+AG + + +A+ ++ + + +RTV A E + S L+
Sbjct: 190 IAGAAMSLIMSKMAGRGQVAYAEAGNVVEQTVGAIRTVVAFTGEKQATEKYESKLEIAYK 249
Query: 1059 SYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAG 880
+ ++ +I G G + F Y ++ +G L++ + V+ + G
Sbjct: 250 TVVQQGLISGFGLGTMLAVIFCSYGLAVWYGAKLIMEKGYNGGQVINVIFAVLTGGMSLG 309
Query: 879 SAVAYLPDHRKAIHAAGLIFHLFTY-PAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSD 703
L AA +F P I YD S G+IELK+V F Y R D
Sbjct: 310 QTSPSLNAFAAGRAAAFKMFETIKRSPKIDAYDMSGSVLEDIRGDIELKDVYFRYPARPD 369
Query: 702 KMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHL 523
I G SL +P G+T+ALVG SGSGKST+ISL+ERFY G+V ID ++ + L +
Sbjct: 370 VQIFAGFSLFVPNGKTVALVGQSGSGKSTVISLIERFYDPESGQVLIDNIDLKKLQLKWI 429
Query: 522 RESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVG 343
R + LVSQEPVLF +IKEN +G +A+ EI A+++ANA F+ + PQGLDT+VG
Sbjct: 430 RSKIGLVSQEPVLFATTIKENIAYG-KEDATDQEIRTAIELANAAKFIDKLPQGLDTMVG 488
Query: 342 ERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVV 163
E G Q+SGGQKQR+AIARAIL+NPK+LLLDEATSALD++SE++VQ+AL +TVVV
Sbjct: 489 EHGTQMSGGQKQRLAIARAILKNPKILLLDEATSALDAESERIVQDALVNLMSNRTTVVV 548
Query: 162 AHRLSTVVNADSIAVLKNGKVAEQGTHEELLR-KRSIYWRLVQKQ 31
AHRL+T+ AD IAV+ GK+ E+GTH+E+++ Y +LV+ Q
Sbjct: 549 AHRLTTIRTADVIAVVHQGKIVEKGTHDEMIQDPEGAYSQLVRLQ 593
>gi|15228052|ref|NP_181228.1| multidrug resistance P-glycoprotein
(PGP1) [Arabidopsis thaliana]
gi|419760|pir||A42150 P-glycoprotein pgp1 - Arabidopsis thaliana
gi|3849833|emb|CAA43646.1| P-glycoprotein [Arabidopsis thaliana]
gi|4883607|gb|AAD31576.1| putative ABC transporter [Arabidopsis
thaliana]
Length = 1286
Score = 656 bits (1693), Expect = 0.0
Identities = 415/1187 (34%), Positives = 645/1187 (53%), Gaps = 38/1187 (3%)
Frame = -1
Query: 3477 RVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDG-MSTGHL 3301
+ L F +VG A + + + S + G+ +R +Y+ L +DI +FD + T +
Sbjct: 88 KYALYFLVVGAAIWASSWAEISCWMWSGERQTTKMRIKYLEAALNQDIQFFDTEVRTSDV 147
Query: 3300 SIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLL 3121
+N + ++ +EK+ I + FV G I+ F W+LA I + G +
Sbjct: 148 VFAINTDAVMVQDAISEKLGNFIHYMATFVSGFIVGFTAVWQLALVTLAVVPLIAVIGGI 207
Query: 3120 DSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNR 2941
+ K + K E +S AG+I Q + + V + G+ + + Y+ LK +K
Sbjct: 208 HTTTLSKLSNKSQESLSQAGNIVEQTVVQIRVVMAFVGESRASQAYSSALKIAQKLGYKT 267
Query: 2940 AFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEAILH 2761
+ A YF ++L++G ++ G+ + ++ ++ G LG++
Sbjct: 268 GLAKGMGLGATYFVVFCCYALLLWYGGYLVRHHLTNGGLAIATMFAVMIGGLALGQSAPS 327
Query: 2760 ISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPTRPDVPVL 2584
++ A A I I+ D T + ++ D+ G++ KNV FSYP+RPDV +L
Sbjct: 328 MAAFAKAKVAAAKIFRII-DHKPTIERNSESGVELDSVTGLVELKNVDFSYPSRPDVKIL 386
Query: 2583 KEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAM 2404
+V G+ IALVG+SGSGKSTV+ L+ +Y+ +SG++ +DG D+ + ++ LRQ +
Sbjct: 387 NNFCLSVPAGKTIALVGSSGSGKSTVVSLIERFYDPNSGQVLLDGQDLKTLKLRWLRQQI 446
Query: 2403 GVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGERGAQ 2224
G+V QEP LF TSI+ENI G+PDA + EI +A + ANA F+ PDG T VGERG Q
Sbjct: 447 GLVSQEPALFATSIKENILLGRPDADQVEIEEAARVANAHSFIIKLPDGFDTQVGERGLQ 506
Query: 2223 LSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHRLS 2044
LSGGQKQRIAIAR +++NP ILLLDEATSALD+ESE +VQEAL + IGRTT+++AHRLS
Sbjct: 507 LSGGQKQRIAIARAMLKNPAILLLDEATSALDSESEKLVQEALDRFMIGRTTLIIAHRLS 566
Query: 2043 TIRNANKIIVMEKGEIVEVGDHKQLIAM--NGVYNNLVQTQLMSTNYEKMNENEER---- 1882
TIR A+ + V+++G + E+G H +L + NGVY L++ Q + N +
Sbjct: 567 TIRKADLVAVLQQGSVSEIGTHDELFSKGENGVYAKLIKMQEAAHETAMSNARKSSARPS 626
Query: 1881 ----------VTRQSSH---------SDFPSNEISHQKIDQED--DYVKKLIAEIKEEGA 1765
+TR SS+ SDF +++ S ID +Y + +A K++
Sbjct: 627 SARNSVSSPIMTRNSSYGRSPYSRRLSDFSTSDFS-LSIDASSYPNYRNEKLA-FKDQA- 683
Query: 1764 KKSNICEIIKYCRSEYCILFIAVLGSAIQG-----IYYPLSSQLMIKSYEAYAFDKDEML 1600
++ + K E+ + +GS I G Y LS+ L + Y D + M+
Sbjct: 684 --NSFWRLAKMNSPEWKYALLGSVGSVICGSLSAFFAYVLSAVLSV----YYNPDHEYMI 737
Query: 1599 SKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCH 1420
+ + ++ L+ +F Q+ F+ E L+ ++R ++ A++D +
Sbjct: 738 KQIDKYCYLLIGLSSAALVFNTLQHSFWDIVGENLTKRVREKMLSAVLKNEMAWFDQEEN 797
Query: 1419 TATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLY 1240
+ R++ RL D++NV +A+ DR+ ++ +L+A F W+++L ++ P++
Sbjct: 798 ESARIAARLALDANNVRSAIGDRISVIVQNTALMLVACTAGFVLQWRLALVLVAVFPVVV 857
Query: 1239 LAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRN 1060
A F+ + A K + A EA+ NVRTV A N E +++ L T++L+
Sbjct: 858 AATVLQKMFMTGFSGDLEAAHAKGTQLAGEAIANVRTVAAFNSEAKIVRLYTANLEPPLK 917
Query: 1059 SYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAG 880
F + I G+ G A C + YA+ + +WLV T V M L ++A+ A
Sbjct: 918 RCFWKGQIAGSGYGVAQFCLYASYALGLWYASWLVKHGISDFSKTIRVFMVLMVSANGAA 977
Query: 879 SAVAYLPDHRKAIHAAGLIFHLFTYPA-IMPYD-SSQGKRNIKNGEIELKNVSFEYAQRS 706
+ PD K A +F L I P D + + GE+ELK++ F Y R
Sbjct: 978 ETLTLAPDFIKGGQAMRSVFELLDRKTEIEPDDPDTTPVPDRLRGEVELKHIDFSYPSRP 1037
Query: 705 DKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHH 526
D I +SL+ AG+TLALVGPSG GKS++ISL++RFY G V ID +++ NL
Sbjct: 1038 DIQIFRDLSLRARAGKTLALVGPSGCGKSSVISLIQRFYEPSSGRVMIDGKDIRKYNLKA 1097
Query: 525 LRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLV 346
+R+ +++V QEP LF +I EN +G A++ EI QA +A+A F+S P+G T V
Sbjct: 1098 IRKHIAIVPQEPCLFGTTIYENIAYG-HECATEAEIIQAATLASAHKFISALPEGYKTYV 1156
Query: 345 GERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVV 166
GERG QLSGGQKQRIAIARA++R +++LLDEATSALD++SE+ VQ ALD A +++V
Sbjct: 1157 GERGVQLSGGQKQRIAIARALVRKAEIMLLDEATSALDAESERSVQEALDQACSGRTSIV 1216
Query: 165 VAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKR--SIYWRLVQKQ 31
VAHRLST+ NA IAV+ +GKVAEQG+H LL+ IY R++Q Q
Sbjct: 1217 VAHRLSTIRNAHVIAVIDDGKVAEQGSHSHLLKNHPDGIYARMIQLQ 1263
>gi|17567271|ref|NP_510129.1| P-GlycoProtein related (pgp-15)
[Caenorhabditis elegans]
gi|7499666|pir||T21269 hypothetical protein F22E10.4 - Caenorhabditis
elegans
gi|3876294|emb|CAA91802.1| Hypothetical protein F22E10.4
[Caenorhabditis elegans]
Length = 1270
Score = 655 bits (1690), Expect = 0.0
Identities = 423/1255 (33%), Positives = 662/1255 (52%), Gaps = 39/1255 (3%)
Frame = -1
Query: 3666 YEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFES 3487
++ L F+GV+ +I++G+ QP + G +VTNAI + A K F +
Sbjct: 94 FDHFLLFIGVICAIISGVSQPVLTIIAG-------RVTNAI-------LVYAPQTKQFRN 139
Query: 3486 DMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMSTG 3307
V +F +G ++Q+ + +R +Y+ +LR++ +FD +G
Sbjct: 140 KATENVYIFLGIGIFVTITNYIQYMCFQHCCSRIMAQMRHRYVYSVLRQNAGWFDKHHSG 199
Query: 3306 HLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSG 3127
++ LND+MER RE +K+ +++ + V ++A+ +WRLAC + G
Sbjct: 200 TIATKLNDSMERIREGIGDKLGVLLRGVAMLVASVVVAYIYEWRLACM--LLGVAPTCIG 257
Query: 3126 LLDSWGKMKN--NEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKY 2953
+ + K+ + AGSIA ++L +TV + NGQ++ VERY EL G K+
Sbjct: 258 CMSLMARQMTATTVKELGGVEKAGSIAEESLMGVRTVQAFNGQEEMVERYRVELNKGRKF 317
Query: 2952 ALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIE-PGVVVRILYYILFGSYCLG 2776
A+ + F L +F+ A +GA ++ G I+ PG V I+ +L GSY G
Sbjct: 318 AIWKGFWSGLFGGMFFFWLFAFQGCGFLYGAYLLSVGIIKSPGDVFIIVMAMLLGSYFTG 377
Query: 2775 EAILHISRLASAIPLTVPIADILLDSDATADEFFSE-EIKDTFQGIISFKNVLFSYPTRP 2599
H+ L +A I + + D D + + + D G + F+NV F YPTR
Sbjct: 378 LISPHLMVLLNARVAAGSIYETI-DRVPKIDPYSKKGKFLDKVIGRVKFENVHFRYPTRK 436
Query: 2598 DVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQ 2419
D +L ++ ++ G +ALVG SG GKST + LL Y ++G ++IDG D+ +NI
Sbjct: 437 DAKILNGLNLTIEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIDY 496
Query: 2418 LRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVG 2239
LR +G+V QEP+LFN +I N+ G P+AT +++I+ K ANA DF+ P G T++G
Sbjct: 497 LRNVIGIVQQEPILFNDTIHNNLLLGNPNATREKMIEVCKMANAHDFIEKMPKGYDTMIG 556
Query: 2238 ERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVV 2059
+ G QLSGGQKQR+AIARTLVR P++LLLDEATSALD +SE IVQ AL AS GRTTI++
Sbjct: 557 DGGVQLSGGQKQRVAIARTLVREPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMI 616
Query: 2058 AHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYE-KMNENEER 1882
AHRLSTIR A+KI+ EKG IVE G+H++L+ + G Y +LV+ Q + + ++E E+
Sbjct: 617 AHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYYDLVKAQAFKPDNDGTVDEIEDE 676
Query: 1881 V----------TRQSSHSDFPSNEISHQ--------------------KIDQEDDYVKKL 1792
+ +RQSS + +++S + D E+ +
Sbjct: 677 IDLGQSASGLHSRQSSFTSSIRSKMSGAEAFRRGTLGADSFAGGKSTARADAENAAFAEE 736
Query: 1791 IAEIKEE-GAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAF- 1618
+A++ E+ G + +I K + Y ++F+ + I+G+ + L+ +E + +
Sbjct: 737 VAKVMEQDGQISAGYMDIFKNAKGNYTVMFLGFVTGLIRGLELTAFALLLGWVFEGFQYL 796
Query: 1617 --DKDEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPC 1444
D +M+ + ++ F I F FF +E L+++ R MSF++L+
Sbjct: 797 NIDNGKMMHRMAMAVIAYGCSGFGCFISQFLSSIFFAIVSENLALRFRVMSFRNLLYQDA 856
Query: 1443 AFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQV 1264
+F+D+P H +L RL D+ N VD R+ V+ L A+I + S+
Sbjct: 857 SFFDNPAHAPGKLITRLATDAPNCKTVVDSRMLQVLYA----LSAIIANIVISF------ 906
Query: 1263 LMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVT 1084
++C +G C F R N
Sbjct: 907 -IYCH----SGNCTHYFT----------------------------RFYN---------- 923
Query: 1083 SHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTL 904
+ S K+ +I+ S +++ F G L+ P D + + +
Sbjct: 924 ------KRSELKKGLIEAINYTITQSFMYYMMCFCFALGIRLIYHGNKSPQDVFQGNIAM 977
Query: 903 SMTASYAGSAVAYLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSF 724
+TA +A Y P+ KA AAGL+F++ Y D +G R G I +NV F
Sbjct: 978 LLTAMGVMNAAQYFPEFVKAKTAAGLLFNII-YRKPRTGDLLEGSRPEVRGNILFENVKF 1036
Query: 723 EYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVV 544
Y QR + I+ G+ G+T+ALVGPSGSGKST I +LERFY G ++ID +++
Sbjct: 1037 SYPQRPHQPIMKGLQWTALRGQTVALVGPSGSGKSTCIGMLERFYDVTGGTLRIDGQDIR 1096
Query: 543 DVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQ 364
++L HLR ++LV QEP LF +IKEN G+ N +I+ AL++ANA F++ P
Sbjct: 1097 GLSLFHLRTQMALVGQEPRLFAGTIKENICLGLE-NVPMEKINHALELANANRFLANLPA 1155
Query: 363 GLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASE 184
G++T VGE+G++LSGGQKQRIAIARA++R+PK+LLLDEATSALDS+SE+ VQ ALD A E
Sbjct: 1156 GIETDVGEKGSKLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRARE 1215
Query: 183 RLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQV 19
+ + +AHRLS++ N+D I ++NG+V E G H++L+ K+ Y+ L+QKQ + +
Sbjct: 1216 GRTCITIAHRLSSIQNSDVIVYIENGRVQEAGNHKQLMSKKGKYYELIQKQDLGI 1270
Score = 290 bits (741), Expect = 2e-76
Identities = 204/655 (31%), Positives = 337/655 (51%), Gaps = 30/655 (4%)
Frame = -1
Query: 1896 ENEERVTRQSSHSDFPSNEISHQKIDQ------EDDYVKK---------LIAEIKEEG-- 1768
E+ R +RQS+ P+ +S K +DD +KK LI I G
Sbjct: 13 EDIGRNSRQSTIRGVPAFPVSEPKHTSAPIEFVDDDEIKKEYRPSCFDKLIDFILCRGDV 72
Query: 1767 AKKS------NICEIIKYCRS-EYCILFIAVLGSAIQGIYYPLSSQLMIKSYEA---YAF 1618
AK++ +I + +Y ++ ++ +LFI V+ + I G+ P+ + + + A YA
Sbjct: 73 AKRTYETQPVSIFGLFRYAKAFDHFLLFIGVICAIISGVSQPVLTIIAGRVTNAILVYAP 132
Query: 1617 DKDEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAF 1438
+ +K+ L + I + QY F ++ ++R ++ +
Sbjct: 133 QTKQFRNKATENVYIFLGIGIFVTITNYIQYMCFQHCCSRIMAQMRHRYVYSVLRQNAGW 192
Query: 1437 YDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLM 1258
+D H + ++ +LN + + D+LG ++ + ++ +V++++ Y W+++ +L
Sbjct: 193 FDK--HHSGTIATKLNDSMERIREGIGDKLGVLLRGVAMLVASVVVAYIYEWRLACMLLG 250
Query: 1257 FCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSH 1078
P + ++ EK+ A E+L VRTV+A N + ++
Sbjct: 251 VAPTCIGCMSLMARQMTATTVKELGGVEKAGSIAEESLMGVRTVQAFNGQEEMVERYRVE 310
Query: 1077 LQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEIL-PMDTYLVLMTLS 901
L K R + G G F F +G +L+ I P D ++++M +
Sbjct: 311 LNKGRKFAIWKGFWSGLFGGMFFFWLFAFQGCGFLYGAYLLSVGIIKSPGDVFIIVMAML 370
Query: 900 MTASYAGSAVAYLPDHRKAIHAAGLIFHLFT-YPAIMPYDSSQGKRNIKN-GEIELKNVS 727
+ + + G +L A AAG I+ P I PY S +GK K G ++ +NV
Sbjct: 371 LGSYFTGLISPHLMVLLNARVAAGSIYETIDRVPKIDPY-SKKGKFLDKVIGRVKFENVH 429
Query: 726 FEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENV 547
F Y R D IL+G++L + G ++ALVG SG GKST + LL R Y G V ID +V
Sbjct: 430 FRYPTRKDAKILNGLNLTIEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDV 489
Query: 546 VDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFP 367
++N+ +LR + +V QEP+LFN +I N L G + NA++ ++ + K+ANA F+ + P
Sbjct: 490 RELNIDYLRNVIGIVQQEPILFNDTIHNNLLLG-NPNATREKMIEVCKMANAHDFIEKMP 548
Query: 366 QGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTAS 187
+G DT++G+ G QLSGGQKQR+AIAR ++R PKVLLLDEATSALD+ SE +VQ+AL+ AS
Sbjct: 549 KGYDTMIGDGGVQLSGGQKQRVAIARTLVREPKVLLLDEATSALDAQSESIVQSALNNAS 608
Query: 186 ERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQ 22
+ +T+++AHRLST+ AD I + G + E G HEEL+R Y+ LV+ Q +
Sbjct: 609 KGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYYDLVKAQAFK 663
>gi|50556486|ref|XP_505651.1| hypothetical protein [Yarrowia
lipolytica]
gi|49651521|emb|CAG78460.1| unnamed protein product [Yarrowia
lipolytica CLIB99]
Length = 1326
Score = 652 bits (1683), Expect = 0.0
Identities = 424/1249 (33%), Positives = 649/1249 (51%), Gaps = 20/1249 (1%)
Frame = -1
Query: 3708 LKKTFGFQIKCTTRYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTI 3529
+K F + T+ + + F+G+V + G+C P + G+ + N+ +
Sbjct: 108 VKVNFLTLFRYATKLDIFILFIGMVTAAAAGVCMPLFTVIFGQ-----------MTNEFL 156
Query: 3528 DPVDLAHAYKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRL 3349
+ L + F+ +N L F + A F ++ I G+ + +R Y+ +
Sbjct: 157 AFIVLGSSADRFQHQINHYALYFVYIAVATFCLTSIKTYITVERGERLSARIRENYLKAI 216
Query: 3348 LRKDISYFDGMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLA 3169
+R++I YFD + G ++ + + +E +EK+ LI++ ++ F+ ++ F RL
Sbjct: 217 MRQNIGYFDKLGAGEVTNRITTDTNLIQEGISEKLGLIVSAVSSFITSLVIGFIKSARLT 276
Query: 3168 CYGTVFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVE 2989
+VL+ + S ++ E S SIA + + + Q + +
Sbjct: 277 GIMISTVVALVLAMGICSTFLVRYVRWAIEDDSECSSIAEECFASITNIVAFGMQVKMDK 336
Query: 2988 RYTEELKNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRIL 2809
RY + L + K L +A V + T + + L+ G+ ++ +G G V+ +L
Sbjct: 337 RYEKPLNSSLKNYLLKARVLGAMVGILWCITYCMYALALWEGSRLVNKGETSIGHVITVL 396
Query: 2808 YYILFGSYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIKDTFQGIISFK 2629
++ G++ LG ++ L SA+ I + + D D E +G ISFK
Sbjct: 397 MALMIGAFQLGGVAPNMESLGSAVGAGKKIFETI-DRVPDIDSLSGGETLSNLRGAISFK 455
Query: 2628 NVLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDG 2449
NV F YP+RP VP+L+E + ++ G +ALVGASGSGKST++ LL +Y G I++DG
Sbjct: 456 NVHFRYPSRPTVPILREFNLDIPSGATVALVGASGSGKSTIVALLERFYQPLGGSITVDG 515
Query: 2448 NDIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQE----------IIDALK 2299
I ++++K LRQ M +V QEP LFN +I ENI G TE E + DA +
Sbjct: 516 VSILSLDVKWLRQQMSLVSQEPTLFNCTIFENISHGLI-GTEYENAERSVKMKLVEDACE 574
Query: 2298 NANAFDFVCNFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNES 2119
AN +F+ DG+ T VGE+G LSGGQKQR+AIAR ++ NP ILLLDEATSALD S
Sbjct: 575 QANCSEFIKTLTDGLDTQVGEKGYLLSGGQKQRVAIARAIISNPPILLLDEATSALDTRS 634
Query: 2118 EFIVQEALQKASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNL 1939
E +VQ+AL KA+ RTTIV+AHRLSTI+NA+KI+VM KGEI+E G H +LIA G Y L
Sbjct: 635 EKLVQQALDKAAKNRTTIVIAHRLSTIKNADKIVVMSKGEILEQGSHDELIAARGTYYGL 694
Query: 1938 VQTQLMSTNYEKMNENEER--VTRQSSHSDFP-SNEISHQKIDQEDDY-VKKLIAEIKEE 1771
V Q + + E+ S SDF + +S +K + + + KL+A
Sbjct: 695 VGAQRIEDGGPETASTTEKGYYWESGSGSDFDVGSNVSVEKTTPLNTWGMIKLLA----- 749
Query: 1770 GAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDK---DEML 1600
++ R+E L + + I G YP + L +A+ D ML
Sbjct: 750 -----------RFNRNERLPLLLGSGFAVICGAGYPSLALLYGSVMQAFMVDPLAYKHML 798
Query: 1599 SKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCH 1420
+ ++ + + F Q Y+ G +E L L+ F HL++ F+D
Sbjct: 799 HEIDKFSGFFFMVGMVQLGSYFMQVYYLGVASETLVRNLKRTIFSHLLNQDLRFFDTT-- 856
Query: 1419 TATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLY 1240
T +L++ L+ D+ NV G ++ ++V ++++VI+S Y+WK+ L PL+
Sbjct: 857 TTGKLTSSLSKDTQNVQGLGGATFGQILSSIVTVIISVILSCCYTWKLGLVCSACIPLIL 916
Query: 1239 LAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRN 1060
+G+ + Q + +E S A EA N++TV AL E+ V+ +S + +
Sbjct: 917 SSGFFRFYILTQLNQRGRKVYESSAGYACEATNNIQTVMALTREDDVLNFYSSKVNNVVY 976
Query: 1059 SYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAG 880
K I G + + I A+ F +G+ L+ + EI ++ +T+ AG
Sbjct: 977 HSAKSNAISSMLFGASQTLIILINALGFWYGSTLIRKREIDINQFFVAFVTVVFGVQSAG 1036
Query: 879 SAVAYLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGKRNIKN---GEIELKNVSFEYAQR 709
S ++ PD KA A I + + D G G I NV F Y +R
Sbjct: 1037 SIFSFTPDMGKAKVATQSIHEILKVKPEIGGDKESGLSLDPEKVVGNISFDNVRFRYPER 1096
Query: 708 SDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLH 529
+L G+SL +PAG +ALVG SG GKST ISL+ERFY + G + ID ++ D+NL
Sbjct: 1097 PKIPVLQGLSLSIPAGSYVALVGSSGCGKSTTISLIERFYDVLQGSITIDGIDIRDLNLG 1156
Query: 528 HLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTL 349
R +SLV QEP+LF+ +I+EN L G + + A AN +FV P G DT
Sbjct: 1157 SYRSLISLVQQEPILFSGTIRENILLGAEGDVDDATLHSAAIQANIHNFVMSLPDGYDTF 1216
Query: 348 VGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTV 169
G +G LSGGQKQR+AIARA++R+PK+LLLDEATSALDS+SEKVVQ ALDTA++ +T+
Sbjct: 1217 CGNKGTLLSGGQKQRVAIARALIRDPKILLLDEATSALDSESEKVVQQALDTAAQGRTTI 1276
Query: 168 VVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQ 22
VAHRLST+ NADSI VL++GKV EQGTH L+ K+ Y+ LV+ Q ++
Sbjct: 1277 AVAHRLSTIQNADSIYVLEDGKVLEQGTHSHLMAKKGRYYELVKLQALE 1325
>gi|422285|pir||S30327 multidrug resistance protein 1 - Entamoeba
histolytica
gi|158971|gb|AAA29112.1| P-glycoprotein-1
Length = 1302
Score = 652 bits (1682), Expect = 0.0
Identities = 436/1287 (33%), Positives = 666/1287 (50%), Gaps = 48/1287 (3%)
Frame = -1
Query: 3747 KFIKVIVGSTNNFLKKTFGFQIKCTTRYEKLLFFLGVVFSILTGMCQPFESYTLGETSQV 3568
K IK I G N +K+ F + +E +L +G++ SI G P G+
Sbjct: 23 KRIKEIKGGKVN-IKELFRY----AGVFEIILLIIGIIGSIGVGCLNPLLMILTGDVVDT 77
Query: 3567 LVKVTN-AINNKTIDPVDLAHAYKLFES---DMNRVVLLFFLVGFAYFTFGFLQFSIMKF 3400
V N + +I Y++ S +N++VL GFLQ
Sbjct: 78 FVNGENFSKEGGSIKITTEEMNYEIMNSISDTINKLVLKMLYFAIGNMVAGFLQTICFFV 137
Query: 3399 VGDNTAYNVRRQYISRLLRKDISYFDGMSTGHLSIVLNDNMERFREVFNEKIALIIALLT 3220
+ + +R Y LLR+D +FD TG L+ + +++++ ++ + K + +
Sbjct: 138 LSEYQGIKIRSLYFKALLRQDPGWFDCHKTGELTSKIINDIQKIQDGMSLKFGRLFQTFS 197
Query: 3219 DFVIGTILAFYTDWRLACYGT-VFSFGIV-LSGLLDSWGKMKNNEKQNEHISNAGSIAFQ 3046
F+ G ++ F W L +F F +V + GL S G K ++ S A SIA Q
Sbjct: 198 SFITGYLIGFIKCWDLTLVVLCMFPFIMVSMMGLGMSAGIF--TMKSHKPFSEACSIAEQ 255
Query: 3045 ALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNRAFVFSLSRSADYFFTNALNFVILYF 2866
+G +TV SL ++ E Y ++ +KY + ++ FF + N + ++
Sbjct: 256 TIGNIRTVHSLTQERSFCESYNTKIMETDKYNIKKSIGIGTGLGCMMFFIMSSNALGSWY 315
Query: 2865 GANMIYEG-----TIEPGVVVRILYYILFGSYCLGEAILHISRLASAIPLTVPIADILLD 2701
G N + G ++ G V+ + +L + L + I+ L SA V ++
Sbjct: 316 G-NFVVRGKGGSDNVKAGTVLTVFMSVLLATQSLSQISTPINILNSA---KVAAFNVYQT 371
Query: 2700 SDATAD---EFFSEEIKDTFQGIISFKNVLFSYPTRPDVPVLKEISFNVQGGECIALVGA 2530
D D + E G I F++V F YPTR VLK + ++ G+ IALVGA
Sbjct: 372 IDRIPDIDCQSIGGECPTECNGNIRFEDVQFVYPTRLSHHVLKGLDLEIKKGQTIALVGA 431
Query: 2529 SGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAMGVVFQEPVLFNTSIEENI 2350
SG GKST IQL+ Y+ + GR+++DG DI +NIK LR +G+V QEPVLF +I ENI
Sbjct: 432 SGCGKSTTIQLIQRNYDPNGGRVTLDGKDIRELNIKWLRNQIGLVGQEPVLFAGTIRENI 491
Query: 2349 RFGKPDA---TEQEIIDALKNANAFDFVCNFPDGIKTIVGERGAQLSGGQKQRIAIARTL 2179
G + +E+E+I+ K ANA DF+ P+G TI+GE+GA LSGGQKQRIAIAR L
Sbjct: 492 MLGAKEGATPSEEEMIECAKMANAHDFISKLPEGYDTIIGEKGALLSGGQKQRIAIARAL 551
Query: 2178 VRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHRLSTIRNANKIIVMEKGE 1999
+RNP ILLLDEATSALD +SE IVQEAL+KAS GRTTI+VAHRL+T+RNA+KI V +GE
Sbjct: 552 IRNPSILLLDEATSALDTQSEKIVQEALEKASKGRTTIIVAHRLTTVRNADKICVFHQGE 611
Query: 1998 IVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMN-ENEERVTRQSSHSDFPSNEISHQKI 1822
I+E G H++L+ + G Y LV+ Q M ++ EN+ + R+ + + + +
Sbjct: 612 IIEQGKHQELMDLKGTYYGLVKRQSMEEEVDQETVENDLKKFREQEDKEVENISLEQTNL 671
Query: 1821 DQEDDYVKKLIAEIKEEGAKKSNICEIIKY------CRSEYCILFIAVLGSAIQGIYYPL 1660
E+ VK++ E KEE K + + + + EY + ++G G +P
Sbjct: 672 HNENSIVKQIKQEYKEEQKKLKHSNRFVLFRVIWNNYKHEYIFCTLGLIGGIGAGAAFPF 731
Query: 1659 SS-------QLMIKSYEAYAFDKDEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAE 1501
S ++++K + DE + + I+ + I F F E
Sbjct: 732 YSLNFVDLIRVLMKLHPGINL-TDEQANSILRSCMIIICIGIITMISFFCYVGLFMAAGE 790
Query: 1500 KLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVA 1321
K+ ++R + +M +++D + ++ +L +D +++ +R+G +I +
Sbjct: 791 KMIGRIRRRFYYSIMHQNVSWFDRRENMVGAVTTKLTSDPTSLQGISAERVGDIIEIMST 850
Query: 1320 ILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALE 1141
+ + ++SWK+SL +L P++ + N + A+E+ +E +E
Sbjct: 851 VGFGFGIGLYFSWKLSLCILAVFPIISFFMFINGQLNSKNAAPAKAAYEQCGVTLVEVVE 910
Query: 1140 NVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTW 961
++T ++L E+ + LQ + K + N F I A + G
Sbjct: 911 AMKTAQSLGKEDYFSQKYNNDLQIPKRGIIKWGPLLSITNAITNLLTFSINAYGYYLGIC 970
Query: 960 LVLR------------EEILPM--DTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLI 823
+ + +EI+ D LMT++ + LPD KA+ AA I
Sbjct: 971 FMKKTINYQQDVPNFVDEIIDTFGDIQKALMTINSATTSFAQIGNVLPDVGKAVGAAKSI 1030
Query: 822 FHLF-TYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLAL 646
+++ P+I Y N GEIE KN+ F Y R+D +L G+S K G+T+AL
Sbjct: 1031 YNIIDRKPSIDCYSEEGETFNDVKGEIEFKNIHFRYPTRADNEVLKGISFKAEQGKTIAL 1090
Query: 645 VGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIK 466
VG SG GKST I L+ERFY GEV +D N+ D+N+H LR + LV QEPVLF S+
Sbjct: 1091 VGASGCGKSTTIQLIERFYDPTSGEVLLDGHNIKDLNIHFLRNQIGLVGQEPVLFAESVI 1150
Query: 465 ENFLFGISH--NASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIA 292
+N G+ S +I A K+ANA F+S P+G +T+VG+RG+QLSGGQKQRIAIA
Sbjct: 1151 DNIKRGVPEGVEVSNEQIYAAAKMANAHDFISAMPEGYNTMVGDRGSQLSGGQKQRIAIA 1210
Query: 291 RAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLK 112
RA++RNPKVLLLDEATSALDS+SEK+VQ+ALD AS+ +T+V+AHRLST+ NAD I V+
Sbjct: 1211 RALIRNPKVLLLDEATSALDSESEKIVQDALDKASKGRTTIVIAHRLSTIQNADKIYVIM 1270
Query: 111 NGKVAEQGTHEELLRKRSIYWRLVQKQ 31
GK+ EQG H+EL+ + Y+ L +Q
Sbjct: 1271 RGKIVEQGKHQELIDLKGFYYTLAMQQ 1297
Score = 306 bits (785), Expect = 2e-81
Identities = 209/613 (34%), Positives = 322/613 (52%), Gaps = 27/613 (4%)
Frame = -1
Query: 3669 RYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFE 3490
++E + LG++ I G PF S + +VL+K+ IN L +
Sbjct: 709 KHEYIFCTLGLIGGIGAGAAFPFYSLNFVDLIRVLMKLHPGIN--------------LTD 754
Query: 3489 SDMNRVV---LLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDG 3319
N ++ ++ +G F + G+ +RR++ ++ +++S+FD
Sbjct: 755 EQANSILRSCMIIICIGIITMISFFCYVGLFMAAGEKMIGRIRRRFYYSIMHQNVSWFDR 814
Query: 3318 MST--GHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLA-CYGTVF- 3151
G ++ L + + + E++ II +++ G + Y W+L+ C VF
Sbjct: 815 RENMVGAVTTKLTSDPTSLQGISAERVGDIIEIMSTVGFGFGIGLYFSWKLSLCILAVFP 874
Query: 3150 --SFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTE 2977
SF + ++G L+S KN G + + KT SL + ++Y
Sbjct: 875 IISFFMFINGQLNS----KNAAPAKAAYEQCGVTLVEVVEAMKTAQSLGKEDYFSQKYNN 930
Query: 2976 ELKNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGA--------------NMIYEGT 2839
+L+ ++ + + S++ + T ++N Y G N + E
Sbjct: 931 DLQIPKRGIIKWGPLLSITNAITNLLTFSINAYGYYLGICFMKKTINYQQDVPNFVDEII 990
Query: 2838 IEPGVVVRILYYILFGSYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSE-EI 2662
G + + L I + + + + A+ I +I+ D + D + E E
Sbjct: 991 DTFGDIQKALMTINSATTSFAQIGNVLPDVGKAVGAAKSIYNII-DRKPSIDCYSEEGET 1049
Query: 2661 KDTFQGIISFKNVLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYY 2482
+ +G I FKN+ F YPTR D VLK ISF + G+ IALVGASG GKST IQL+ +Y
Sbjct: 1050 FNDVKGEIEFKNIHFRYPTRADNEVLKGISFKAEQGKTIALVGASGCGKSTTIQLIERFY 1109
Query: 2481 NIDSGRISIDGNDIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATE---QEII 2311
+ SG + +DG++I ++NI LR +G+V QEPVLF S+ +NI+ G P+ E ++I
Sbjct: 1110 DPTSGEVLLDGHNIKDLNIHFLRNQIGLVGQEPVLFAESVIDNIKRGVPEGVEVSNEQIY 1169
Query: 2310 DALKNANAFDFVCNFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSAL 2131
A K ANA DF+ P+G T+VG+RG+QLSGGQKQRIAIAR L+RNP++LLLDEATSAL
Sbjct: 1170 AAAKMANAHDFISAMPEGYNTMVGDRGSQLSGGQKQRIAIARALIRNPKVLLLDEATSAL 1229
Query: 2130 DNESEFIVQEALQKASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGV 1951
D+ESE IVQ+AL KAS GRTTIV+AHRLSTI+NA+KI V+ +G+IVE G H++LI + G
Sbjct: 1230 DSESEKIVQDALDKASKGRTTIVIAHRLSTIQNADKIYVIMRGKIVEQGKHQELIDLKGF 1289
Query: 1950 YNNLVQTQLMSTN 1912
Y L Q + N
Sbjct: 1290 YYTLAMQQFGTVN 1302
Score = 285 bits (728), Expect = 8e-75
Identities = 199/623 (31%), Positives = 322/623 (50%), Gaps = 34/623 (5%)
Frame = -1
Query: 1782 IKEEGAKKSNICEIIKYCRS-EYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAY-AFDKD 1609
IKE K NI E+ +Y E +L I ++GS G PL LMI + + F
Sbjct: 25 IKEIKGGKVNIKELFRYAGVFEIILLIIGIIGSIGVGCLNPL---LMILTGDVVDTFVNG 81
Query: 1608 EMLSKS-----------------------HFWALSILFLAFTRPIFIFFQYYFFGKTAEK 1498
E SK + L +L+ A + F Q F +E
Sbjct: 82 ENFSKEGGSIKITTEEMNYEIMNSISDTINKLVLKMLYFAIGNMVAGFLQTICFFVLSEY 141
Query: 1497 LSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAI 1318
IK+RS+ FK L+ ++D CH L++++ D + + + G + T +
Sbjct: 142 QGIKIRSLYFKALLRQDPGWFD--CHKTGELTSKIINDIQKIQDGMSLKFGRLFQTFSSF 199
Query: 1317 LLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALEN 1138
+ ++ F W ++L VL P + ++ + F ++ A + + N
Sbjct: 200 ITGYLIGFIKCWDLTLVVLCMFPFIMVSMMGLGMSAGIFTMKSHKPFSEACSIAEQTIGN 259
Query: 1137 VRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIY--AVSFKFGT 964
+RTV +L E + + + K+++ G G C +F + A+ +G
Sbjct: 260 IRTVHSLTQERSFCESYNTKIMETDKYNIKKSI--GIGTGLGCMMFFIMSSNALGSWYGN 317
Query: 963 WLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLI-FHLF-TYPAIMP 790
++V + ++T+ M+ A +++ + +++A + F+++ T I
Sbjct: 318 FVVRGKGGSDNVKAGTVLTVFMSVLLATQSLSQISTPINILNSAKVAAFNVYQTIDRIPD 377
Query: 789 YD--SSQGKRNIK-NGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKS 619
D S G+ + NG I ++V F Y R +L G+ L++ G+T+ALVG SG GKS
Sbjct: 378 IDCQSIGGECPTECNGNIRFEDVQFVYPTRLSHHVLKGLDLEIKKGQTIALVGASGCGKS 437
Query: 618 TIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISH 439
T I L++R Y G V +D +++ ++N+ LR + LV QEPVLF +I+EN + G
Sbjct: 438 TTIQLIQRNYDPNGGRVTLDGKDIRELNIKWLRNQIGLVGQEPVLFAGTIRENIMLGAKE 497
Query: 438 NA--SQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKV 265
A S+ E+ + K+ANA F+S+ P+G DT++GE+GA LSGGQKQRIAIARA++RNP +
Sbjct: 498 GATPSEEEMIECAKMANAHDFISKLPEGYDTIIGEKGALLSGGQKQRIAIARALIRNPSI 557
Query: 264 LLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGT 85
LLLDEATSALD+ SEK+VQ AL+ AS+ +T++VAHRL+TV NAD I V G++ EQG
Sbjct: 558 LLLDEATSALDTQSEKIVQEALEKASKGRTTIIVAHRLTTVRNADKICVFHQGEIIEQGK 617
Query: 84 HEELLRKRSIYWRLVQKQGIQVE 16
H+EL+ + Y+ LV++Q ++ E
Sbjct: 618 HQELMDLKGTYYGLVKRQSMEEE 640
>gi|22655312|gb|AAM98246.1| putative ABC transporter [Arabidopsis
thaliana]
Length = 1286
Score = 651 bits (1679), Expect = 0.0
Identities = 413/1187 (34%), Positives = 643/1187 (53%), Gaps = 38/1187 (3%)
Frame = -1
Query: 3477 RVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDG-MSTGHL 3301
+ L F +VG A + + + S + G+ +R +Y+ L +DI +FD + T +
Sbjct: 88 KYALYFLVVGAAIWASSWAEISCWMWSGERQTTKMRIKYLEAALNQDIQFFDTEVRTSDV 147
Query: 3300 SIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLL 3121
+N + ++ +EK+ I + FV G I+ F W+LA I + G +
Sbjct: 148 VFAINTDAVMVQDAISEKLGNFIHYMATFVSGFIVGFTAVWQLALVTLAVVPLIAVIGGI 207
Query: 3120 DSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNR 2941
+ K + K E +S AG+I Q + + V + G+ + + Y+ LK +K
Sbjct: 208 HTTTLSKLSNKSQESLSQAGNIVEQTVVQIRVVMAFVGESRASQAYSSALKIAQKLGYKT 267
Query: 2940 AFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEAILH 2761
+ A YF ++L++ ++ G+ + ++ ++ G LG++
Sbjct: 268 GLAKGMGLGATYFVVFCCYALLLWYDGYLVRHHLTNGGLAIATMFAVMIGGLALGQSAPS 327
Query: 2760 ISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPTRPDVPVL 2584
++ A A I I+ D T + ++ D+ G++ KNV FSYP+RPDV +L
Sbjct: 328 MAAFAKAKVAAAKIFRII-DHKPTIERNSESGVELDSVTGLVELKNVDFSYPSRPDVKIL 386
Query: 2583 KEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAM 2404
+V G+ IALVG+SGSGKSTV+ L+ +Y+ +SG++ +DG D+ + ++ LRQ +
Sbjct: 387 NNFCLSVPAGKTIALVGSSGSGKSTVVSLIERFYDPNSGQVLLDGQDLKTLKLRWLRQQI 446
Query: 2403 GVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGERGAQ 2224
G+V QEP LF TSI+ENI G+PDA + EI +A + ANA F+ PDG T VGERG Q
Sbjct: 447 GLVSQEPALFATSIKENILLGRPDADQVEIEEAARVANAHSFIIKLPDGFDTQVGERGLQ 506
Query: 2223 LSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHRLS 2044
LSGGQKQRIAIAR +++NP ILLLDEATSALD+ESE +VQEAL + IGRTT+++AHRLS
Sbjct: 507 LSGGQKQRIAIARAMLKNPAILLLDEATSALDSESEKLVQEALDRFMIGRTTLIIAHRLS 566
Query: 2043 TIRNANKIIVMEKGEIVEVGDHKQLIAM--NGVYNNLVQTQLMSTNYEKMNENEER---- 1882
TIR A+ + V+++G + E+G H +L + NGVY L++ Q + N +
Sbjct: 567 TIRKADLVAVLQQGSVSEIGTHDELFSKGENGVYAKLIKMQEAAHETAMSNARKSSARPS 626
Query: 1881 ----------VTRQSSH---------SDFPSNEISHQKIDQED--DYVKKLIAEIKEEGA 1765
+TR SS+ SDF +++ S ID +Y + +A K++
Sbjct: 627 SARNSVSSPIMTRNSSYGRSPYSRRLSDFSTSDFS-LSIDASSYPNYRNEKLA-FKDQA- 683
Query: 1764 KKSNICEIIKYCRSEYCILFIAVLGSAIQG-----IYYPLSSQLMIKSYEAYAFDKDEML 1600
++ + K E+ + +GS I G Y LS+ L + Y D + M+
Sbjct: 684 --NSFWRLAKMNSPEWKYALLGSVGSVICGSLSAFFAYVLSAVLSV----YYNPDHEYMI 737
Query: 1599 SKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCH 1420
+ + ++ L+ +F Q+ F+ E L+ ++R ++ A++D +
Sbjct: 738 KQIDKYCYLLIGLSSAALVFNTLQHSFWDIVGENLTKRVREKMLSAVLKNEMAWFDQEEN 797
Query: 1419 TATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLY 1240
+ R++ RL D++NV +A+ DR+ ++ +L+A F W+++L ++ P++
Sbjct: 798 ESARIAARLALDANNVRSAIGDRISVIVQNTALMLVACTAGFVLQWRLALVLVAVFPVVV 857
Query: 1239 LAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRN 1060
A F+ + A K + A EA+ NVRTV A N E +++ L T++L+
Sbjct: 858 AATVLQKMFMTGFSGDLEAAHAKGTQLAGEAIANVRTVAAFNSEAKIVRLYTANLEPPLK 917
Query: 1059 SYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAG 880
F + I G+ G A C + YA+ + +WLV T V M L ++A+ A
Sbjct: 918 RCFWKGQIAGSGYGVAQFCLYASYALGLWYASWLVKHGISDFSKTIRVFMVLMVSANGAA 977
Query: 879 SAVAYLPDHRKAIHAAGLIFHLFTYPA-IMPYD-SSQGKRNIKNGEIELKNVSFEYAQRS 706
+ PD K A +F L I P D + + GE+ELK++ F Y R
Sbjct: 978 ETLTLAPDFIKGGQAMRSVFELLDRKTEIEPDDPDTTPVPDRLRGEVELKHIDFSYPSRP 1037
Query: 705 DKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHH 526
D I +SL+ AG+TLALVGPSG GKS++ISL++RFY G V ID +++ NL
Sbjct: 1038 DIQIFRDLSLRARAGKTLALVGPSGCGKSSVISLIQRFYEPSSGRVMIDGKDIRKYNLKA 1097
Query: 525 LRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLV 346
+R+ +++V QEP LF +I EN +G A++ EI QA +A+A F+S P+G T V
Sbjct: 1098 IRKHIAIVPQEPCLFGTTIYENIAYG-HECATEAEIIQAATLASAHKFISALPEGYKTYV 1156
Query: 345 GERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVV 166
GERG QLSGGQKQRIAIARA++R +++LLD ATSALD++SE+ VQ ALD A +++V
Sbjct: 1157 GERGVQLSGGQKQRIAIARALVRKAEIMLLDGATSALDAESERSVQEALDQACSGRTSIV 1216
Query: 165 VAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKR--SIYWRLVQKQ 31
VAHRLST+ NA IAV+ +GKVAEQG+H LL+ IY R++Q Q
Sbjct: 1217 VAHRLSTIRNAHVIAVIDDGKVAEQGSHSHLLKNHPDGIYARMIQLQ 1263
>gi|393116|gb|AAA93553.1| P-glycoprotein 5
Length = 1301
Score = 650 bits (1676), Expect = 0.0
Identities = 439/1271 (34%), Positives = 676/1271 (52%), Gaps = 60/1271 (4%)
Frame = -1
Query: 3663 EKLLFFLGVVFSILTGMCQPFESYTLGE--TSQVLVKVTNAINNKTIDPVDLAHAYKLFE 3490
+ +L +G++ SI G+ QP +G+ S + N I ++ ++ + + K E
Sbjct: 47 DMILLVVGLISSIGNGVMQPLMMLLMGDMVNSYIYTPGDNTIIDEEVNHM-IVEGVK--E 103
Query: 3489 SDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMST 3310
S+ VV FL+ + V VRR Y LLR+D +++D +
Sbjct: 104 SENKVVVKNGIYYEVISMVLSFLRTFSLFVVSQREGIRVRRLYFKSLLRQDATWYDFQES 163
Query: 3309 GHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACY--GTV--FSFG 3142
G L+ + +++ +++ K +I +++ + G ++ F W LA TV SF
Sbjct: 164 GELTARIATDIKNYQDGIGPKFGMIFQIISMVITGCVIEFKKCWDLALVVLATVPFSSFS 223
Query: 3141 IVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNG 2962
+ ++ MK K + AG+IA + +G +TV SLN + + + Y E++K
Sbjct: 224 FTIFQIIG----MKYETKALKVFGAAGAIAEETIGNIRTVQSLNQKNEFIAEYQEKIKQN 279
Query: 2961 EKY-ALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGT-----IEPGVVVRILYYI 2800
E + + + S R + F ++ + + +++ G + G V+ + +
Sbjct: 280 EHFNGIKGQCLMSWIRFSVITFFMIASYALGSWYGSLVIRGKGGSKGVFAGHVLTVFLSV 339
Query: 2799 LFGSYCLGEAILHISRL----ASAIPLTVPIADILLDSDATADEFFSEEIKDTFQGIISF 2632
L S L + ++ L ASA + I D + D D + E G I F
Sbjct: 340 LSASQTLSMIAILLNLLFSDKASAYKIFTTI-DRIPDIDCQS---IGGECPTECNGNIRF 395
Query: 2631 KNVLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISID 2452
+V F YPTRP VLK + ++ GE IALVGASG GKST IQL+ Y + GR+++D
Sbjct: 396 VDVQFVYPTRPSHHVLKGLDIEIKKGETIALVGASGCGKSTTIQLIQRNYEPNGGRVTLD 455
Query: 2451 GNDIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDA---TEQEIIDALKNANAFD 2281
G DI +NIK LR +G+V QE VLF+ +I ENI G + ++ E+I+ K ANA++
Sbjct: 456 GKDIRELNIKWLRNQIGLVGQESVLFSGTIRENIMLGAKEGETLSKDEMIECAKVANAYE 515
Query: 2280 FVCNFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQE 2101
FV +G T++GE+GA LSGGQKQRIAIAR L+RNP ILLLDEATSALD +SE IVQE
Sbjct: 516 FVSKLAEGYDTLIGEKGALLSGGQKQRIAIARALIRNPSILLLDEATSALDTQSEKIVQE 575
Query: 2100 ALQKASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLM 1921
AL+KAS GRTTI+VAHRL+T+RNA++I V +GEI+E G H++LI + G Y LV+ Q M
Sbjct: 576 ALEKASKGRTTIIVAHRLTTVRNADQICVFHQGEIIEQGKHQELIDLKGTYYGLVKGQSM 635
Query: 1920 STNYEKMN-ENEERVTRQSSHSDFPSNEISHQKIDQEDDYVKKLIAEIKEEGAKKSNICE 1744
E+ EN+ + R+ + N I + D+E++ + ++++IKEE K+ I +
Sbjct: 636 EEEVEQETVENDIKKFRKQEDKEV-ENIIVEESHDEEEE--EDIVSKIKEEYEKEKKIRK 692
Query: 1743 ----------IIKYCRSEYCILFIAVLGSAIQGIYYPLSS----QLMIKSYE-----AYA 1621
+I+ R + + +A +G + G +P+ + L++ E
Sbjct: 693 KRNRFSIIRIMIEQLRMNFVLFILATIGGIVGGAVFPIFTIKFIDLIVMMMELQDGVELT 752
Query: 1620 FDKDEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCA 1441
++ L + W + I AF + + F +AE L +R FK ++
Sbjct: 753 DEQQHTLVNTIIWVMGI---AFAGLLSTYCYIGIFASSAEYLIGSVRRRMFKSIVKQEIG 809
Query: 1440 FYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVL 1261
++D + L RL++D + + LG ++ L I A + +Y WK++L V+
Sbjct: 810 WFDRKENRVGSLVTRLSSDPTKLNGITGVILGHIVYILSTICFAFGFALYYDWKLALCVI 869
Query: 1260 MFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTS 1081
P+ L + + A+E+S +EA+E+++TV++L E + +
Sbjct: 870 AVFPIHTLILFFDFKLNSMQSSPAEKAYEESGITLVEAVESMKTVQSLTREEYFLKQYSL 929
Query: 1080 HLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLR------------EEIL 937
+L+K S FK +I N F + A + GT+L+ + +E
Sbjct: 930 NLKKPYKSIFKWGLILALVNAITNLSNFIVDAYGYYLGTYLLAKNLNYTQTNQGFYQEF- 988
Query: 936 PMDTYLVLMTLSMTASYAGSAVA----YLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGK 769
MD Y+ + M+ +A V +PD K++ AA ++L A DSS+
Sbjct: 989 -MDRYMKIQKAIMSVVFAAHGVGNFGEIIPDIGKSMKAARHSYNLIDRNA--KIDSSEIN 1045
Query: 768 RNIKN---GEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLE 598
N N GEIE KN+ F Y R+D +L G+S K G+T+ALVG SG GKST I L+E
Sbjct: 1046 GNTFNDVKGEIEFKNIRFRYPTRADNEVLKGISFKADQGKTIALVGASGCGKSTTIQLVE 1105
Query: 597 RFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISH--NASQL 424
RFY GEV +D N+ D+N+ LR + LV QEPVLF S+ +N G+ S
Sbjct: 1106 RFYDPTSGEVLLDGYNIKDLNVKFLRNQIGLVGQEPVLFAESVIDNIKRGVPEGVEVSNE 1165
Query: 423 EIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEAT 244
+I A K+ANA F+S P+G +T+VG+RG+QLSGGQKQRIAIARA++RNPKVLLLDEAT
Sbjct: 1166 QIYAAAKMANAHDFISAMPEGYNTMVGDRGSQLSGGQKQRIAIARALIRNPKVLLLDEAT 1225
Query: 243 SALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRK 64
SALD+ SEK+VQ+ALD AS+ +T+++AHRLST+ NAD I V+ GK+ EQGTH+EL+
Sbjct: 1226 SALDTQSEKIVQDALDKASKGRTTIIIAHRLSTIQNADQICVIMRGKIVEQGTHQELMDL 1285
Query: 63 RSIYWRLVQKQ 31
+ Y+ L +Q
Sbjct: 1286 KGFYYTLAMQQ 1296
Score = 292 bits (747), Expect = 5e-77
Identities = 194/519 (37%), Positives = 291/519 (55%), Gaps = 30/519 (5%)
Frame = -1
Query: 3378 NVRRQYISRLLRKDISYFDGMST--GHLSIVLNDNMERFREVFNEKIALIIALLTDFVIG 3205
+VRR+ +++++I +FD G L L+ + + + + I+ +L+
Sbjct: 794 SVRRRMFKSIVKQEIGWFDRKENRVGSLVTRLSSDPTKLNGITGVILGHIVYILSTICFA 853
Query: 3204 TILAFYTDWRLA-CYGTVFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYK 3028
A Y DW+LA C VF ++ M+++ + + +G +A+ K
Sbjct: 854 FGFALYYDWKLALCVIAVFPIHTLILFFDFKLNSMQSSPAEKAY-EESGITLVEAVESMK 912
Query: 3027 TVSSLNGQQQEVERYTEELKNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFG----- 2863
TV SL ++ +++Y+ LK K + +L + TN NF++ +G
Sbjct: 913 TVQSLTREEYFLKQYSLNLKKPYKSIFKWGLILALVNA----ITNLSNFIVDAYGYYLGT 968
Query: 2862 ----ANMIYEGTIEPGV---------VVRILYYILFGSYCLG---EAILHISRLASAIPL 2731
N+ Y T + + + + ++F ++ +G E I I + A
Sbjct: 969 YLLAKNLNYTQTNQGFYQEFMDRYMKIQKAIMSVVFAAHGVGNFGEIIPDIGKSMKAARH 1028
Query: 2730 TVPIADILLDSDATADEFFSEEIKDTF---QGIISFKNVLFSYPTRPDVPVLKEISFNVQ 2560
+ L+D +A D SE +TF +G I FKN+ F YPTR D VLK ISF
Sbjct: 1029 SYN----LIDRNAKIDS--SEINGNTFNDVKGEIEFKNIRFRYPTRADNEVLKGISFKAD 1082
Query: 2559 GGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAMGVVFQEPV 2380
G+ IALVGASG GKST IQL+ +Y+ SG + +DG +I ++N+K LR +G+V QEPV
Sbjct: 1083 QGKTIALVGASGCGKSTTIQLVERFYDPTSGEVLLDGYNIKDLNVKFLRNQIGLVGQEPV 1142
Query: 2379 LFNTSIEENIRFGKPDATE---QEIIDALKNANAFDFVCNFPDGIKTIVGERGAQLSGGQ 2209
LF S+ +NI+ G P+ E ++I A K ANA DF+ P+G T+VG+RG+QLSGGQ
Sbjct: 1143 LFAESVIDNIKRGVPEGVEVSNEQIYAAAKMANAHDFISAMPEGYNTMVGDRGSQLSGGQ 1202
Query: 2208 KQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHRLSTIRNA 2029
KQRIAIAR L+RNP++LLLDEATSALD +SE IVQ+AL KAS GRTTI++AHRLSTI+NA
Sbjct: 1203 KQRIAIARALIRNPKVLLLDEATSALDTQSEKIVQDALDKASKGRTTIIIAHRLSTIQNA 1262
Query: 2028 NKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTN 1912
++I V+ +G+IVE G H++L+ + G Y L Q + N
Sbjct: 1263 DQICVIMRGKIVEQGTHQELMDLKGFYYTLAMQQFGTVN 1301
Score = 272 bits (695), Expect = 5e-71
Identities = 193/626 (30%), Positives = 318/626 (49%), Gaps = 39/626 (6%)
Frame = -1
Query: 1776 EEGAKKSNICEIIKYCR-SEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDE-- 1606
+E K ++ ++ KY + +L + ++ S G+ PL LM +Y + +
Sbjct: 28 QETEGKVSVIKLFKYSDWIDMILLVVGLISSIGNGVMQPLMMLLMGDMVNSYIYTPGDNT 87
Query: 1605 ---------------------MLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSI 1489
++ ++ + + L+F R +F +++ I
Sbjct: 88 IIDEEVNHMIVEGVKESENKVVVKNGIYYEVISMVLSFLRTFSLFV-------VSQREGI 140
Query: 1488 KLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLA 1309
++R + FK L+ +YD + L+ R+ D N + + G + + ++
Sbjct: 141 RVRRLYFKSLLRQDATWYD--FQESGELTARIATDIKNYQDGIGPKFGMIFQIISMVITG 198
Query: 1308 VIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSI-AFEKSNRAAIEALENVR 1132
++ F W ++L VL P + + + E ++ F + A E + N+R
Sbjct: 199 CVIEFKKCWDLALVVLATVPFSSFS-FTIFQIIGMKYETKALKVFGAAGAIAEETIGNIR 257
Query: 1131 TVRALNMENRVILLVTSHLQKIR-NSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTW-- 961
TV++LN +N I + +KI+ N +F Q + S F S+ G+W
Sbjct: 258 TVQSLNQKNEFI---AEYQEKIKQNEHFNGIKGQCLMSWIRFSVITFFMIASYALGSWYG 314
Query: 960 -LVLREEILPMDTY----LVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFHLFTYPAI 796
LV+R + + L + ++AS S +A L + + A+ + +FT
Sbjct: 315 SLVIRGKGGSKGVFAGHVLTVFLSVLSASQTLSMIAILLNLLFSDKASA--YKIFTTIDR 372
Query: 795 MPYDSSQ---GKRNIK-NGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGS 628
+P Q G+ + NG I +V F Y R +L G+ +++ G T+ALVG SG
Sbjct: 373 IPDIDCQSIGGECPTECNGNIRFVDVQFVYPTRPSHHVLKGLDIEIKKGETIALVGASGC 432
Query: 627 GKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFG 448
GKST I L++R Y G V +D +++ ++N+ LR + LV QE VLF+ +I+EN + G
Sbjct: 433 GKSTTIQLIQRNYEPNGGRVTLDGKDIRELNIKWLRNQIGLVGQESVLFSGTIRENIMLG 492
Query: 447 ISHNA--SQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRN 274
S+ E+ + KVANA+ FVS+ +G DTL+GE+GA LSGGQKQRIAIARA++RN
Sbjct: 493 AKEGETLSKDEMIECAKVANAYEFVSKLAEGYDTLIGEKGALLSGGQKQRIAIARALIRN 552
Query: 273 PKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAE 94
P +LLLDEATSALD+ SEK+VQ AL+ AS+ +T++VAHRL+TV NAD I V G++ E
Sbjct: 553 PSILLLDEATSALDTQSEKIVQEALEKASKGRTTIIVAHRLTTVRNADQICVFHQGEIIE 612
Query: 93 QGTHEELLRKRSIYWRLVQKQGIQVE 16
QG H+EL+ + Y+ LV+ Q ++ E
Sbjct: 613 QGKHQELIDLKGTYYGLVKGQSMEEE 638
>gi|14715462|dbj|BAB62040.1| CjMDR1 [Coptis japonica]
Length = 1289
Score = 648 bits (1672), Expect = 0.0
Identities = 407/1230 (33%), Positives = 643/1230 (52%), Gaps = 24/1230 (1%)
Frame = -1
Query: 3657 LLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFESDMN 3478
LL +G + ++ G P + LG+ + NA N T+ V +
Sbjct: 69 LLMVIGTIAAVANGASMPVMTLLLGDLINAFGQ--NANNTDTLRVV-------------S 113
Query: 3477 RVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDG-MSTGHL 3301
+V L F + F Q + G+ A +R Y+ +LR+D+++FD +TG +
Sbjct: 114 KVALKFVYLSIGAGVASFFQVACWMVTGERQAARIRSLYLKTILRQDVAFFDKETNTGEV 173
Query: 3300 SIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLL 3121
++ + ++ EK+ I L + F+ G ++AF W L +V G L
Sbjct: 174 VGRMSGDTVLIQDAIGEKVGKFIQLFSTFIGGFLIAFVKGWLLTLVMLTSIPPLVFCGAL 233
Query: 3120 DSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNR 2941
+ K + S AG + Q +G +TV+S G++ V +Y + L ++
Sbjct: 234 MTITISKMASRGQVAYSQAGIVVEQTIGSIRTVASFTGEKHAVTQYEKYLNKAYLAGIHE 293
Query: 2940 AFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEAILH 2761
+ + + ++FG MI E G V+ I+ +L GS LG+A
Sbjct: 294 GLASGVGLGSVLLVIFCSYSLAVWFGGKMIIEKGYNGGNVINIIVAVLTGSMSLGQASPC 353
Query: 2760 ISRLASAIPLTVPIADILLDSDATADEFFSEEIKDTFQGIISFKNVLFSYPTRPDVPVLK 2581
+ A+ + + + S D +G I ++V F+YP RPD +
Sbjct: 354 LGAFAAGQAAAYKMLETIKRKPEIDSYDTSGHKSDDIRGDIELRDVSFTYPARPDEQIFN 413
Query: 2580 EISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAMG 2401
S + G ALVG SGSGKSTVI L+ +Y+ +G + IDG ++ + ++ +R +G
Sbjct: 414 GFSLFIPSGTTSALVGQSGSGKSTVISLIERFYDPQAGEVLIDGVNLKDFQLRWIRGKIG 473
Query: 2400 VVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGERGAQL 2221
+V QEPVLF +SI +NI +GK AT +EI A + ANA F+ P G+ T+VGE G QL
Sbjct: 474 LVSQEPVLFASSIRDNIAYGKDGATVEEIKAATERANASKFIDKLPQGLDTLVGEHGTQL 533
Query: 2220 SGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHRLST 2041
SGGQKQRIAIAR ++++PRILLLDEATSALD ESE IVQEAL + + RTT++VAHRLST
Sbjct: 534 SGGQKQRIAIARAILKDPRILLLDEATSALDAESEHIVQEALDRIMVNRTTVIVAHRLST 593
Query: 2040 IRNANKIIVMEKGEIVEVGDHKQLIAM-NGVYNNLVQTQLMSTNYEKMNENEER------ 1882
+RNA+ I V+ +G+IVE G H L+ +G Y L++ Q + + EN E
Sbjct: 594 VRNADTIAVIHRGKIVEKGSHLDLLLNPDGAYCQLIRLQEIGRSEVDKAENVESGLNSSQ 653
Query: 1881 -------VTRQSSHSDFPSNEISHQKIDQEDDYVKKLIAEIKEEG------AKKSNICEI 1741
++R SS S ++ + A ++ ++ + +
Sbjct: 654 QHSIGRSISRGSSGVGNSSRHSFSVSFGLPTGHIYETTAGLESTSPAPIGQTQEVPLRRL 713
Query: 1740 IKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWALSILFL 1561
+ E +L + V+ + + G+ +P+ L+ + + +D++ + FWA + L
Sbjct: 714 ATLNKPEIPVLLLGVISAMVNGVIFPIFGVLLSSVIKTFYEPEDKLRKDTRFWAFMFIIL 773
Query: 1560 AFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADS 1381
+ YFF +L ++RSM F+ + + ++D+P H + + +L+AD+
Sbjct: 774 GVASFVAAPATAYFFAVAGCRLIQRIRSMCFRTVAHMEIDWFDEPEHASGAIGAKLSADA 833
Query: 1380 SNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQA 1201
S V V D L ++ + ++++F +W ++L +L+ PL+ + GY F+
Sbjct: 834 STVRGLVGDALALLVQNAATAVCGLVIAFVANWTLALIILVLIPLIGVNGYVQMKFMKGF 893
Query: 1200 VEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTAN 1021
+ + +E++++ A +A+ ++RTV + E +V+ L + + ++ +I G
Sbjct: 894 SADAKMMYEEASQVANDAVGSIRTVASFCAEEKVMQLYKKKCEGPMKTGIRQGLISGIGF 953
Query: 1020 GFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAI 841
G + F +YA SF G LV + D + V L+M A + + PD KA
Sbjct: 954 GISFFLLFNVYATSFYAGARLVDAGKTTFSDVFRVFFALTMAALGISQSSSLAPDSSKAK 1013
Query: 840 HAAGLIFHLFTYPAIMPYDSSQGK--RNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLP 667
+ IF + + + G N+K GEIEL+++SF+Y R D I +SL +
Sbjct: 1014 SSTASIFGILDRKSKIDSSDESGMTVENVK-GEIELRHISFKYPTRPDIQIFRDLSLAIH 1072
Query: 666 AGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPV 487
+G+T+ALVG SGSGKST+ISLL+RFY G + +D + L LR + LVSQEPV
Sbjct: 1073 SGKTVALVGESGSGKSTVISLLQRFYDPDSGHITLDGIEIQKFQLRWLRLQMGLVSQEPV 1132
Query: 486 LFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQ 307
LFN +I+ N +G +A++ EI A ++ANA F+S QG DT+VGERG QLSGGQKQ
Sbjct: 1133 LFNETIRANIAYGKEGDATETEILAAAELANAHKFISGLQQGYDTVVGERGIQLSGGQKQ 1192
Query: 306 RIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADS 127
R+AIARA+++ PK+LLLDEATSALD++SE+VVQ+ALD +TV VAHRLST+ NAD
Sbjct: 1193 RVAIARAMVKAPKILLLDEATSALDAESERVVQDALDKVMVNRTTVWVAHRLSTIKNADV 1252
Query: 126 IAVLKNGKVAEQGTHEELLR-KRSIYWRLV 40
IAV+KNG +AE+G H +L+ K +Y LV
Sbjct: 1253 IAVVKNGVIAEKGKHNDLINVKDGVYASLV 1282
Score = 313 bits (801), Expect = 3e-83
Identities = 202/601 (33%), Positives = 323/601 (53%), Gaps = 14/601 (2%)
Frame = -1
Query: 1785 EIKEEGAKKSNICEIIKYCR-------SEYCILFIAVLGSAIQGIYYPLSSQLM---IKS 1636
E E+ ++ I + + Y + + ++ I + + G P+ + L+ I +
Sbjct: 39 EKSEKSKEEEKIGQSVPYYKLLSFADSKDVLLMVIGTIAAVANGASMPVMTLLLGDLINA 98
Query: 1635 YEAYAFDKDEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLM 1456
+ A + D + S AL ++L+ + FFQ + T E+ + ++RS+ K ++
Sbjct: 99 FGQNANNTDTLRVVSKV-ALKFVYLSIGAGVASFFQVACWMVTGERQAARIRSLYLKTIL 157
Query: 1455 SLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKM 1276
AF+D +T + R++ D+ + A+ +++G I + +++F W +
Sbjct: 158 RQDVAFFDKETNTG-EVVGRMSGDTVLIQDAIGEKVGKFIQLFSTFIGGFLIAFVKGWLL 216
Query: 1275 SLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVI 1096
+L +L P L G + + +A+ ++ + + ++RTV + E +
Sbjct: 217 TLVMLTSIPPLVFCGALMTITISKMASRGQVAYSQAGIVVEQTIGSIRTVASFTGEKHAV 276
Query: 1095 LLVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILP---MDT 925
+L K + + G G F Y+++ FG +++ + ++
Sbjct: 277 TQYEKYLNKAYLAGIHEGLASGVGLGSVLLVIFCSYSLAVWFGGKMIIEKGYNGGNVINI 336
Query: 924 YLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEI 745
+ ++T SM+ A + + A + ++ + P I YD+S K + G+I
Sbjct: 337 IVAVLTGSMSLGQASPCLGAFAAGQAAAYK--MLETIKRKPEIDSYDTSGHKSDDIRGDI 394
Query: 744 ELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVK 565
EL++VSF Y R D+ I +G SL +P+G T ALVG SGSGKST+ISL+ERFY GEV
Sbjct: 395 ELRDVSFTYPARPDEQIFNGFSLFIPSGTTSALVGQSGSGKSTVISLIERFYDPQAGEVL 454
Query: 564 IDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFS 385
ID N+ D L +R + LVSQEPVLF SI++N +G A+ EI A + ANA
Sbjct: 455 IDGVNLKDFQLRWIRGKIGLVSQEPVLFASSIRDNIAYG-KDGATVEEIKAATERANASK 513
Query: 384 FVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQN 205
F+ + PQGLDTLVGE G QLSGGQKQRIAIARAIL++P++LLLDEATSALD++SE +VQ
Sbjct: 514 FIDKLPQGLDTLVGEHGTQLSGGQKQRIAIARAILKDPRILLLDEATSALDAESEHIVQE 573
Query: 204 ALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTH-EELLRKRSIYWRLVQKQG 28
ALD +TV+VAHRLSTV NAD+IAV+ GK+ E+G+H + LL Y +L++ Q
Sbjct: 574 ALDRIMVNRTTVIVAHRLSTVRNADTIAVIHRGKIVEKGSHLDLLLNPDGAYCQLIRLQE 633
Query: 27 I 25
I
Sbjct: 634 I 634
>gi|27368865|emb|CAD59590.1| MDR-like ABC transporter [Oryza sativa
(japonica cultivar-group)]
gi|46485796|gb|AAS98421.1| MDR-like ABC transporter [Oryza sativa
(japonica cultivar-group)]
Length = 1276
Score = 648 bits (1671), Expect = 0.0
Identities = 400/1168 (34%), Positives = 642/1168 (54%), Gaps = 30/1168 (2%)
Frame = -1
Query: 3483 MNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDG-MSTG 3307
++ V L F + A F+Q + G+ A +R Y+ +LR+++++FD +TG
Sbjct: 96 VSEVSLQFIYLAVASAAASFIQVACWMITGERQAARIRSLYLRTILRQEVAFFDKHTNTG 155
Query: 3306 HLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSG 3127
+ ++ + ++ EK+ + LL F+ G +AF W L +VLSG
Sbjct: 156 EVVGRMSGDTVLIQDAMGEKVGKFVQLLVTFLGGFGVAFAQGWLLTLVMLATIPPLVLSG 215
Query: 3126 LLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYAL 2947
+ S + ++A + Q +G +TV+S G++Q V +Y+ LK +
Sbjct: 216 AVMSNVVARMASLGQAAYADASVVVEQTIGSIRTVASFTGEKQAVAKYSRSLKRAYSSGV 275
Query: 2946 NRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEAI 2767
+ + +++GA +I E V+ +++ +L GS LG+A
Sbjct: 276 REGLAAGVGMGTVMVLLFCGYSLGIWYGAKLILEKGYTGAQVMNVIFAVLTGSLALGQAS 335
Query: 2766 LHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPTRPDVP 2590
+ A + + + + + D + + K D QG I F+NV FSYPTRPD
Sbjct: 336 PSMKAFAGGQAAAYKMFETI-NREPEIDAYSATGRKLDDIQGDIEFRNVYFSYPTRPDEQ 394
Query: 2589 VLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQ 2410
+ + S +Q G +ALVG SGSGKSTVI L+ +Y+ G + IDG ++ + ++ +R
Sbjct: 395 IFRGFSLAIQSGTTVALVGQSGSGKSTVISLIERFYDPQLGEVLIDGVNLKELQLRWIRS 454
Query: 2409 AMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGERG 2230
+G+V QEP+LF SI +NI +G+ +AT QEI A + ANA F+ P G T+VGE G
Sbjct: 455 KIGLVSQEPILFAASIIDNIAYGRDNATNQEIRAAAELANASKFIDKMPQGFATLVGEHG 514
Query: 2229 AQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHR 2050
QLSGGQKQRIAIAR ++++PRILLLDEATSALD ESE IVQEAL + RTT++VAHR
Sbjct: 515 TQLSGGQKQRIAIARAILKDPRILLLDEATSALDTESERIVQEALDRVMSNRTTVIVAHR 574
Query: 2049 LSTIRNANKIIVMEKGEIVEVGDHKQLIA-MNGVYNNLVQTQLMSTNYEKMN-------- 1897
L+T+RNA+ I V+ +G IVE G H +LI+ +G Y+ L++ Q S + E N
Sbjct: 575 LTTVRNADTIAVIHQGSIVEKGSHHELISDPDGAYSQLIRLQENSHDSEDANYQNKSGKK 634
Query: 1896 ---------------ENEERVTRQSSHSDFPSNEISHQKIDQEDDYVKKLIAEIKEEGAK 1762
+R +R +S++ S + +ID + KK I EE +
Sbjct: 635 SDSGIRSGKQSFSYQSTPQRSSRDNSNNHSFSVSATPLEIDVQGGSPKK----IAEETPQ 690
Query: 1761 KSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSK-SHF 1585
+ + + + E +L + + SA+ G+ +P+ + L+ +A+ ++ ++L K + F
Sbjct: 691 EVPLSRLAALNKPEIPVLLLGSVASAVSGVIFPIFAILLSNVIKAF-YEPPQVLKKDAEF 749
Query: 1584 WALSILFLAFTRPIFIFFQY--YFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTAT 1411
W S +FL F F+ Y F +L ++R M+F+ ++++ ++D P +++
Sbjct: 750 W--SSMFLVFGAVYFLSLPIGSYLFSVAGCRLIRRIRLMTFEKVVNMEIEWFDHPENSSG 807
Query: 1410 RLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAG 1231
+ RL+AD++ + V D L V+ L ++ ++++F +W++SL +L PL+ + G
Sbjct: 808 SIGARLSADAAKIRGLVGDALQLVVQNLATLVAGLLIAFISNWELSLIILALIPLIGVNG 867
Query: 1230 YCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYF 1051
+ F+ + + +E++++ A +A+ ++RTV + + E +V+ L + +
Sbjct: 868 WIQMKFIQGFSADAKMMYEEASQVANDAVSSIRTVASFSAEEKVMDLYKMKCEGPLRTGI 927
Query: 1050 KRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAV 871
+ A+I G G + F +YA SF G LV + + + V + L+M A
Sbjct: 928 RTAIISGIGFGVSIFLLFGVYAASFYAGARLVEDRKTTFPNVFRVFLALTMAAIGVSHTS 987
Query: 870 AYLPDHRKAIHAAGLIFHLFTYPA-IMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMI 694
D KA A IF + + I P D + G+IE ++VSF Y R D I
Sbjct: 988 NLTSDSSKAKSAVSSIFAIVDRKSRIDPSDDAGVSLEPLRGDIEFQHVSFRYPTRPDVQI 1047
Query: 693 LDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRES 514
+ + L + +G+T+ALVG SGSGKST ISLL+RFY G + +D ++ L LR+
Sbjct: 1048 FEDLCLTIQSGKTVALVGESGSGKSTAISLLQRFYDPDAGHILLDGVDIQKFQLRWLRQQ 1107
Query: 513 VSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERG 334
+ LVSQEP LFN +I+ N +G +A++ +I + ++ANA F+S QG +T+VGERG
Sbjct: 1108 MGLVSQEPALFNDTIRANIAYGKEGDATESDIVSSAQLANAHKFISSLHQGYETMVGERG 1167
Query: 333 AQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHR 154
AQLSGGQKQRIAIARAI+++PK+LLLDEATSALD++SE+VVQ+ALD +TV+VAHR
Sbjct: 1168 AQLSGGQKQRIAIARAIVKDPKILLLDEATSALDAESERVVQDALDRVMMNRTTVIVAHR 1227
Query: 153 LSTVVNADSIAVLKNGKVAEQGTHEELL 70
LST+ AD IAV+KNG + E+G H+ L+
Sbjct: 1228 LSTIQGADMIAVVKNGMIIEKGKHDALI 1255
Score = 286 bits (731), Expect = 4e-75
Identities = 184/521 (35%), Positives = 282/521 (53%), Gaps = 11/521 (2%)
Frame = -1
Query: 3465 LFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGM--STGHLSIV 3292
+F + G YF + + G +R +++ +I +FD S+G +
Sbjct: 753 MFLVFGAVYFLSLPIGSYLFSVAGCRLIRRIRLMTFEKVVNMEIEWFDHPENSSGSIGAR 812
Query: 3291 LNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLLDSW 3112
L+ + + R + + + L++ L V G ++AF ++W L+ + I L G+ + W
Sbjct: 813 LSADAAKIRGLVGDALQLVVQNLATLVAGLLIAFISNWELSL---IILALIPLIGV-NGW 868
Query: 3111 GKMKN----NEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALN 2944
+MK + A +A A+ +TV+S + +++ ++ Y + + + +
Sbjct: 869 IQMKFIQGFSADAKMMYEEASQVANDAVSSIRTVASFSAEEKVMDLYKMKCEGPLRTGIR 928
Query: 2943 RAFVFSLSRSADYFFTNALNFVILYFGANMIYEG-TIEPGV--VVRILYYILFGSYCLGE 2773
A + + F + Y GA ++ + T P V V L G
Sbjct: 929 TAIISGIGFGVSIFLLFGVYAASFYAGARLVEDRKTTFPNVFRVFLALTMAAIGVSHTSN 988
Query: 2772 AILHISRLASAIPLTVPIADILLDSDATADEFFSEEIKDTFQGIISFKNVLFSYPTRPDV 2593
S+ SA+ I D D + D S E +G I F++V F YPTRPDV
Sbjct: 989 LTSDSSKAKSAVSSIFAIVDRKSRIDPSDDAGVSLE---PLRGDIEFQHVSFRYPTRPDV 1045
Query: 2592 PVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLR 2413
+ +++ +Q G+ +ALVG SGSGKST I LL +Y+ D+G I +DG DI ++ LR
Sbjct: 1046 QIFEDLCLTIQSGKTVALVGESGSGKSTAISLLQRFYDPDAGHILLDGVDIQKFQLRWLR 1105
Query: 2412 QAMGVVFQEPVLFNTSIEENIRFGKP-DATEQEIIDALKNANAFDFVCNFPDGIKTIVGE 2236
Q MG+V QEP LFN +I NI +GK DATE +I+ + + ANA F+ + G +T+VGE
Sbjct: 1106 QQMGLVSQEPALFNDTIRANIAYGKEGDATESDIVSSAQLANAHKFISSLHQGYETMVGE 1165
Query: 2235 RGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVA 2056
RGAQLSGGQKQRIAIAR +V++P+ILLLDEATSALD ESE +VQ+AL + + RTT++VA
Sbjct: 1166 RGAQLSGGQKQRIAIARAIVKDPKILLLDEATSALDAESERVVQDALDRVMMNRTTVIVA 1225
Query: 2055 HRLSTIRNANKIIVMEKGEIVEVGDHKQLIAM-NGVYNNLV 1936
HRLSTI+ A+ I V++ G I+E G H LI + +G Y +LV
Sbjct: 1226 HRLSTIQGADMIAVVKNGMIIEKGKHDALIGIKDGAYASLV 1266
>gi|27368849|emb|CAD59582.1| MDR-like ABC transporter [Oryza sativa
(japonica cultivar-group)]
gi|38344910|emb|CAD41854.2| OSJNBb0079B02.13 [Oryza sativa (japonica
cultivar-group)]
gi|38347317|emb|CAE05967.2| OSJNBa0063C18.8 [Oryza sativa (japonica
cultivar-group)]
Length = 1268
Score = 647 bits (1670), Expect = 0.0
Identities = 387/1171 (33%), Positives = 631/1171 (53%), Gaps = 19/1171 (1%)
Frame = -1
Query: 3486 DMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFD-GMST 3310
++++ L F +G + + + + G+ +R+ Y+ +LR+D+ +FD T
Sbjct: 97 EVSKYALYFVYLGLVVCASSYAEIACWMYTGERQVIALRKAYLDAVLRQDVGFFDTDART 156
Query: 3309 GHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLS 3130
G + ++ + ++ EK+ I + F+ G ++ F WRLA I +
Sbjct: 157 GDIVFGVSTDTLLVQDAIGEKVGNFIHYIATFLAGLVVGFVAAWRLALLSVAVIPAIAFA 216
Query: 3129 GLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYA 2950
G L ++ K E +NAG +A QA+ +TV S G+ + + Y+E ++N K
Sbjct: 217 GGLYAYTLTGLTSKSRESYANAGVVAEQAIAQVRTVYSFAGESKALNSYSEAIQNTLKLG 276
Query: 2949 LNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEA 2770
L Y ++ ++ I G + G ++ + G LG+A
Sbjct: 277 YKAGMAKGLGIGCTYGIACMSWALVFWYAGVFIRNGQTDGGKAFTAIFSAIVGGMSLGQA 336
Query: 2769 ILHISRLASAIPLTVPIADILLDSDATADEFFSEEIKDTFQGIISFKNVLFSYPTRPDVP 2590
++ + + +++ + + ++ G I FK+V FSYP+RPDV
Sbjct: 337 FSNLGAFSKGKIAGYKLLEVIRQKPSIVHDHKDGKLLAEVHGNIEFKDVTFSYPSRPDVM 396
Query: 2589 VLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQ 2410
+ ++ S + +A+VG SGSGKSTV+ L+ +Y+ + G++ +D DI + ++ LR
Sbjct: 397 IFRDFSLFFPAAKTVAVVGGSGSGKSTVVALIERFYDPNEGQVLLDNVDIKTLQLRWLRD 456
Query: 2409 AMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGERG 2230
+G+V QEP LF T+I ENI +GKPDAT E+ A +NA F+ P+G T+VGERG
Sbjct: 457 QIGLVNQEPALFATTIHENILYGKPDATMAEVEAAATASNAHSFISTLPNGYNTMVGERG 516
Query: 2229 AQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHR 2050
QLSGGQKQRIAIAR +++NP+ILLLDEATSALD SE IVQEAL + GRTT+VVAHR
Sbjct: 517 IQLSGGQKQRIAIARAMLKNPKILLLDEATSALDAGSENIVQEALDRLMTGRTTVVVAHR 576
Query: 2049 LSTIRNANKIIVMEKGEIVEVGDHKQLIA--MNGVYNNLVQTQLMSTNYE---------- 1906
LSTIRN N I V+++G++VE G H +L+A +G Y +L++ Q M+ N +
Sbjct: 577 LSTIRNVNMIAVIQQGQVVETGTHDELLAKGSSGAYASLIRFQEMAQNRDLGGASTRRSR 636
Query: 1905 KMNENEERVTRQSSHSDFPSNEISHQKIDQEDDYVKKL--IAEIKEEGAKKSNICEIIKY 1732
M+ T+ S +S+Q + ++ + ++ A + +++K
Sbjct: 637 SMHLTSSLSTKSLSLRSGSLRNLSYQYSTGANGRIEMISNADNDRKYPAPRGYFFKLLKL 696
Query: 1731 CRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAF-DKDEMLSKSHFWALSILFLAF 1555
E+ + +GS + G P + +M + + + + D +EM K+ + +
Sbjct: 697 NAPEWPYAVLGAVGSVLSGFIGPTFAIVMGEMLDVFYYRDPNEMEKKTKLYVFIYIGTGL 756
Query: 1554 TRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSN 1375
+ Q+YFF E L+ ++R M +++ ++D+ + ++ ++ RL D+++
Sbjct: 757 YAVVAYLVQHYFFSIMGENLTTRVRRMMLSAILTNEVGWFDEEENNSSLVAARLAVDAAD 816
Query: 1374 VTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVE 1195
V +A+ +R+ ++ + +++ + I+ F W+++L +L PLL LA + +
Sbjct: 817 VKSAIAERISVILQNMTSLMTSFIVGFIIEWRVALLILATFPLLVLANFAQQLSMKGFAG 876
Query: 1194 EDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGF 1015
+ + A KS+ A E + N+RTV A N +N+++ L + L+ +R+ G G
Sbjct: 877 DTAKAHAKSSMVAGEGVSNIRTVAAFNAQNKILSLFSYELRIPEQQILRRSQTSGLLFGL 936
Query: 1014 ACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHA 835
+ C + A+ +G+ LV V + L +TA+ V+ P+ + +
Sbjct: 937 SQLCLYSSEALILWYGSHLVRSHGSTFSKVIKVFVVLVVTANSVAETVSLAPEIVRGGES 996
Query: 834 AGLIFHLFTYPAIMPYDSSQGKR--NIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAG 661
IF + + D + +R N++ G+IEL++V F Y R D I +LK+ AG
Sbjct: 997 IRSIFGILNRATRIEPDDPESERVTNVR-GDIELRHVDFAYPARPDIQIFKDFNLKIQAG 1055
Query: 660 RTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLF 481
R+ ALVG SGSGKST+I+L+ERFY G+V ID +++ +NL LR + LV QEPVLF
Sbjct: 1056 RSQALVGASGSGKSTVIALIERFYDPTGGKVTIDGKDIRRLNLKALRLKIGLVQQEPVLF 1115
Query: 480 NCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRI 301
SI EN +G A++ E+ QA K AN FVSQ P G T VGERG QLSGGQKQRI
Sbjct: 1116 AASILENIAYG-KDGATEEEVIQAAKTANVHGFVSQLPNGYKTAVGERGVQLSGGQKQRI 1174
Query: 300 AIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIA 121
AIARA+L++P +LLLDEATSALD++SE V+Q AL+ + +TV+VAHRLST+ D IA
Sbjct: 1175 AIARAVLKDPAILLLDEATSALDAESECVLQEALERLMKGRTTVLVAHRLSTIRGVDRIA 1234
Query: 120 VLKNGKVAEQGTHEELL-RKRSIYWRLVQKQ 31
V+++G++ E G+H +L+ R Y RL+Q Q
Sbjct: 1235 VVQDGRIVEHGSHSDLVSRPEGAYSRLLQLQ 1265
>gi|266518|sp|Q00449|MDR4_DROME Multidrug resistance protein homolog
49 (P-glycoprotein 49)
gi|103251|pir||A41249 multidrug resistance protein homolog Mdr49 -
fruit fly (Drosophila melanogaster)
gi|157871|gb|AAA28679.1| P glycoprotein
gi|16198339|gb|AAL14020.1| SD10012p [Drosophila melanogaster]
Length = 1302
Score = 645 bits (1663), Expect = 0.0
Identities = 423/1297 (32%), Positives = 685/1297 (52%), Gaps = 63/1297 (4%)
Frame = -1
Query: 3726 GSTNNFLKKTFGFQI-KCTTRYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTN 3550
GS + +K F + + +TR E+ L + ++ + P+ GE + +LV T
Sbjct: 20 GSVVDATRKYSYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGEFTSLLVDRTV 79
Query: 3549 AINNKTIDPVDLAHAYKLF----------ESDMNRVVL-------LFFLVG-FAYFTFGF 3424
+ T P A A +F + + N+ ++ + LVG A F
Sbjct: 80 GVG--TSSP---AFALPMFGGGQQLTNASKEENNQAIIDDATAFGIGSLVGSVAMFLLIT 134
Query: 3423 LQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMSTGHLSIVLNDNMERFREVFNEKI 3244
L + + N +R+ ++ +LR+DI+++D S + + + +++++ +E EKI
Sbjct: 135 LAIDLANRIALNQIDRIRKLFLEAMLRQDIAWYDTSSGSNFASKMTEDLDKLKEGIGEKI 194
Query: 3243 ALIIALLTDFVIGTILAFYTDWRL-----ACYGTVFSFGIVLSGLLDSWGKMKNNEKQNE 3079
+++ L+ FVIG + AF W+L +C + + V++ L S EK+ +
Sbjct: 195 VIVVFLIMTFVIGIVSAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLA-----EKELK 249
Query: 3078 HISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNRAFVFSLSRSADYFF 2899
S+A ++ + +TV + +GQ++E ER+ + L E + + + +
Sbjct: 250 SYSDAANVVEEVFSGIRTVFAFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLI 309
Query: 2898 TNALNFVILYFGANMIYEG------TIEPGVVVRILYYILFGSYCLGEAILHISRLASAI 2737
+ +++G +I + P V+V +L+ ++ G+ LG A H+ +A A
Sbjct: 310 IYLCMALAIWYGVTLILDERDLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVAT 369
Query: 2736 PLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPTRPDVPVLKEISFNVQ 2560
+ +I+ D + D + + + G I F+ + F YP RPDV +LK ++ +V
Sbjct: 370 AAGQTLFNII-DRPSQVDPMDEKGNRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVL 428
Query: 2559 GGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAMGVVFQEPV 2380
G+ +A VGASG GKST+IQL+ +Y+ ++G + +DG D+ +N+ LR +GVV QEPV
Sbjct: 429 PGQTVAFVGASGCGKSTLIQLMQRFYDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPV 488
Query: 2379 LFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGERGAQLSGGQKQR 2200
LF T+I ENIR+G+P AT+ +I A + AN DF+ P G T VGE+GAQ+SGGQKQR
Sbjct: 489 LFATTIGENIRYGRPSATQADIEKAARAANCHDFITRLPKGYDTQVGEKGAQISGGQKQR 548
Query: 2199 IAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHRLSTIRNANKI 2020
IAIAR LVR P++LLLDEATSALD SE VQ AL+ AS G TT+VVAHRLSTI NA+KI
Sbjct: 549 IAIARALVRQPQVLLLDEATSALDPTSEKRVQSALELASQGPTTLVVAHRLSTITNADKI 608
Query: 2019 IVMEKGEIVEVGDHKQLIAMNGVYNNLV----------------------QTQLMS---- 1918
+ ++ G + E G H++L+ G+Y LV ++Q +S
Sbjct: 609 VFLKDGVVAEQGTHEELMERRGLYCELVSITQRKEATEADEGAVAGRPLQKSQNLSDEET 668
Query: 1917 TNYEKMNENEERVTRQSSHSDFPSNEISHQKIDQEDDYVKKLIAEIKEEGAKKSNICEII 1738
+ E+ E +E Q+S S S + + + KK + +E K + +++
Sbjct: 669 DDDEEDEEEDEEPELQTSGSSRDSGFRASTRRKRRSQRRKK---KKDKEVVSKVSFTQLM 725
Query: 1737 KYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWALSILF-- 1564
K E+ + + + S + G +PL L + D D+ + ++ +S++F
Sbjct: 726 KLNSPEWRFIVVGGIASVMHGATFPLWG-LFFGDFFGILSDGDDDVVRAEVLKISMIFVG 784
Query: 1563 LAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNAD 1384
+ + Q Y F K++ +LR +F ++ A++DD ++ L +RL +D
Sbjct: 785 IGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASD 844
Query: 1383 SSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQ 1204
SNV A R+G+++ + +++ +++ F +SW+ +L L+ PL+ L+ Y F+ +
Sbjct: 845 CSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMK 904
Query: 1203 AVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTA 1024
+ ++ + E++++ A+EA+ N+RTV L +E +V+ + ++ + ++ +G
Sbjct: 905 SAQKAKASIEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDRVDVACRRKVRFRGLV 964
Query: 1023 NGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKA 844
+ F Y +S +G LV E + D V L + G A+AY P+ A
Sbjct: 965 FALGQAAPFLAYGISMYYGGILVAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNVNDA 1024
Query: 843 IHAAGLIFHLFTYPAIMPYDSSQGKRNIK--NGEIELKNVSFEYAQRSDKMILDGVSLKL 670
I +AG + LF + P ++ G+I +NV FEY R IL G++L +
Sbjct: 1025 ILSAGRLMDLFKRTSTQPNPPQSPYNTVEKSEGDIVYENVGFEYPTRKGTPILQGLNLTI 1084
Query: 669 PAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEP 490
T+ALVGPSGSGKST + LL R+Y V G V + + L LR + LVSQEP
Sbjct: 1085 KKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVSQEP 1144
Query: 489 VLFNCSIKENFLFG--ISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGG 316
VLF+ +I EN +G + S EI +A K +N +F+S PQG DT +G + +QLSGG
Sbjct: 1145 VLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLG-KTSQLSGG 1203
Query: 315 QKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVN 136
QKQRIAIARA++RNPK+L+LDEATSALD +SEKVVQ ALD A + + +AHRL+TV N
Sbjct: 1204 QKQRIAIARALVRNPKILILDEATSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRN 1263
Query: 135 ADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGI 25
AD I VLK G V E GTH+EL+ IY L Q +
Sbjct: 1264 ADLICVLKRGVVVEHGTHDELMALNKIYANLYLMQQV 1300
Score = 288 bits (738), Expect = 5e-76
Identities = 176/534 (32%), Positives = 297/534 (54%), Gaps = 10/534 (1%)
Frame = -1
Query: 3489 SDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGM-- 3316
+++ ++ ++F +G LQ + G +R++ ++ +DI+YFD
Sbjct: 773 AEVLKISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERN 832
Query: 3315 STGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIV 3136
S G L L + + ++ ++ + V+G ++ F W+ V +
Sbjct: 833 SVGALCSRLASDCSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVC 892
Query: 3135 LSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGE- 2959
LS L+ MK+ +K I A +A +A+ +TV+ L ++Q +++Y +++ +
Sbjct: 893 LSVYLEGRFIMKSAQKAKASIEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDRVDV 952
Query: 2958 ---KYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGS 2788
+ R VF+L ++A + + +Y+G ++ E + ++++ ++FGS
Sbjct: 953 ACRRKVRFRGLVFALGQAAPFLAYG----ISMYYGGILVAEERMNYEDIIKVAEALIFGS 1008
Query: 2787 YCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSE-EIKDTFQGIISFKNVLFSY 2611
+ LG+A+ + + AI + D+ + + S + +G I ++NV F Y
Sbjct: 1009 WMLGQALAYAPNVNDAILSAGRLMDLFKRTSTQPNPPQSPYNTVEKSEGDIVYENVGFEY 1068
Query: 2610 PTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNI 2431
PTR P+L+ ++ ++ +ALVG SGSGKST +QLLL YY+ SG +++ G
Sbjct: 1069 PTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEF 1128
Query: 2430 NIKQLRQAMGVVFQEPVLFNTSIEENIRFG---KPDATEQEIIDALKNANAFDFVCNFPD 2260
+ LR +G+V QEPVLF+ +I ENI +G + D + QEII+A K +N +F+ P
Sbjct: 1129 PLDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISALPQ 1188
Query: 2259 GIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASI 2080
G T +G+ +QLSGGQKQRIAIAR LVRNP+IL+LDEATSALD ESE +VQ+AL +A
Sbjct: 1189 GYDTRLGKT-SQLSGGQKQRIAIARALVRNPKILILDEATSALDLESEKVVQQALDEARS 1247
Query: 2079 GRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMS 1918
GRT + +AHRL+T+RNA+ I V+++G +VE G H +L+A+N +Y NL Q +S
Sbjct: 1248 GRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELMALNKIYANLYLMQQVS 1301
>gi|24653245|ref|NP_523724.2| CG3879-PA [Drosophila melanogaster]
gi|21627300|gb|AAF58437.2| CG3879-PA [Drosophila melanogaster]
Length = 1302
Score = 645 bits (1663), Expect = 0.0
Identities = 423/1297 (32%), Positives = 685/1297 (52%), Gaps = 63/1297 (4%)
Frame = -1
Query: 3726 GSTNNFLKKTFGFQI-KCTTRYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTN 3550
GS + +K F + + +TR E+ L + ++ + P+ GE + +LV T
Sbjct: 20 GSVVDATRKYSYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGEFTSLLVDRTV 79
Query: 3549 AINNKTIDPVDLAHAYKLF----------ESDMNRVVL-------LFFLVG-FAYFTFGF 3424
+ T P A A +F + + N+ ++ + LVG A F
Sbjct: 80 GVG--TSSP---AFALPMFGGGQQLTNASKEENNQAIIDDATAFGIGSLVGSVAMFLLIT 134
Query: 3423 LQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMSTGHLSIVLNDNMERFREVFNEKI 3244
L + + N +R+ ++ +LR+DI+++D S + + + +++++ +E EKI
Sbjct: 135 LAIDLANRIALNQIDRIRKLFLEAMLRQDIAWYDTSSGSNFASKMTEDLDKLKEGIGEKI 194
Query: 3243 ALIIALLTDFVIGTILAFYTDWRL-----ACYGTVFSFGIVLSGLLDSWGKMKNNEKQNE 3079
+++ L+ FVIG + AF W+L +C + + V++ L S EK+ +
Sbjct: 195 VIVVFLIMTFVIGIVSAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLA-----EKELK 249
Query: 3078 HISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNRAFVFSLSRSADYFF 2899
S+A ++ + +TV + +GQ++E ER+ + L E + + + +
Sbjct: 250 SYSDAANVVEEVFSGIRTVFAFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLI 309
Query: 2898 TNALNFVILYFGANMIYEG------TIEPGVVVRILYYILFGSYCLGEAILHISRLASAI 2737
+ +++G +I + P V+V +L+ ++ G+ LG A H+ +A A
Sbjct: 310 IYLCMALAIWYGVTLILDERDLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVAT 369
Query: 2736 PLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSYPTRPDVPVLKEISFNVQ 2560
+ +I+ D + D + + + G I F+ + F YP RPDV +LK ++ +V
Sbjct: 370 AAGQTLFNII-DRPSQVDPMDEKGNRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVL 428
Query: 2559 GGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAMGVVFQEPV 2380
G+ +A VGASG GKST+IQL+ +Y+ ++G + +DG D+ +N+ LR +GVV QEPV
Sbjct: 429 PGQTVAFVGASGCGKSTLIQLMQRFYDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPV 488
Query: 2379 LFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGERGAQLSGGQKQR 2200
LF T+I ENIR+G+P AT+ +I A + AN DF+ P G T VGE+GAQ+SGGQKQR
Sbjct: 489 LFATTIGENIRYGRPSATQADIEKAARAANCHDFITRLPKGYDTQVGEKGAQISGGQKQR 548
Query: 2199 IAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHRLSTIRNANKI 2020
IAIAR LVR P++LLLDEATSALD SE VQ AL+ AS G TT+VVAHRLSTI NA+KI
Sbjct: 549 IAIARALVRQPQVLLLDEATSALDPTSEKRVQSALELASQGPTTLVVAHRLSTITNADKI 608
Query: 2019 IVMEKGEIVEVGDHKQLIAMNGVYNNLV----------------------QTQLMS---- 1918
+ ++ G + E G H++L+ G+Y LV ++Q +S
Sbjct: 609 VFLKDGVVAEQGTHEELMERRGLYCELVSITQRKEATEADEGAVAGRPLQKSQNLSDEET 668
Query: 1917 TNYEKMNENEERVTRQSSHSDFPSNEISHQKIDQEDDYVKKLIAEIKEEGAKKSNICEII 1738
+ E+ E +E Q+S S S + + + KK + +E K + +++
Sbjct: 669 DDDEEDEEEDEEPELQTSGSSRDSGFRASTRRKRRSQRRKK---KKDKEVVSKVSFTQLM 725
Query: 1737 KYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWALSILF-- 1564
K E+ + + + S + G +PL L + D D+ + ++ +S++F
Sbjct: 726 KLNSPEWRFIVVGGIASVMHGATFPLWG-LFFGDFFGILSDGDDDVVRAEVLKISMIFVG 784
Query: 1563 LAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNAD 1384
+ + Q Y F K++ +LR +F ++ A++DD ++ L +RL +D
Sbjct: 785 IGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASD 844
Query: 1383 SSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQ 1204
SNV A R+G+++ + +++ +++ F +SW+ +L L+ PL+ L+ Y F+ +
Sbjct: 845 CSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMK 904
Query: 1203 AVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTA 1024
+ ++ + E++++ A+EA+ N+RTV L +E +V+ + ++ + ++ +G
Sbjct: 905 SAQKAKASIEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDRVDIACRRKVRFRGLV 964
Query: 1023 NGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKA 844
+ F Y +S +G LV E + D V L + G A+AY P+ A
Sbjct: 965 FALGQAAPFLAYGISMYYGGILVAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNVNDA 1024
Query: 843 IHAAGLIFHLFTYPAIMPYDSSQGKRNIK--NGEIELKNVSFEYAQRSDKMILDGVSLKL 670
I +AG + LF + P ++ G+I +NV FEY R IL G++L +
Sbjct: 1025 ILSAGRLMDLFKRTSTQPNPPQSPYNTVEKSEGDIVYENVGFEYPTRKGTPILQGLNLTI 1084
Query: 669 PAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEP 490
T+ALVGPSGSGKST + LL R+Y V G V + + L LR + LVSQEP
Sbjct: 1085 KKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVSQEP 1144
Query: 489 VLFNCSIKENFLFG--ISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGG 316
VLF+ +I EN +G + S EI +A K +N +F+S PQG DT +G + +QLSGG
Sbjct: 1145 VLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLG-KTSQLSGG 1203
Query: 315 QKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVN 136
QKQRIAIARA++RNPK+L+LDEATSALD +SEKVVQ ALD A + + +AHRL+TV N
Sbjct: 1204 QKQRIAIARALVRNPKILILDEATSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRN 1263
Query: 135 ADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGI 25
AD I VLK G V E GTH+EL+ IY L Q +
Sbjct: 1264 ADLICVLKRGVVVEHGTHDELMALNKIYANLYLMQQV 1300
Score = 288 bits (738), Expect = 5e-76
Identities = 176/534 (32%), Positives = 297/534 (54%), Gaps = 10/534 (1%)
Frame = -1
Query: 3489 SDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGM-- 3316
+++ ++ ++F +G LQ + G +R++ ++ +DI+YFD
Sbjct: 773 AEVLKISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERN 832
Query: 3315 STGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIV 3136
S G L L + + ++ ++ + V+G ++ F W+ V +
Sbjct: 833 SVGALCSRLASDCSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVC 892
Query: 3135 LSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGE- 2959
LS L+ MK+ +K I A +A +A+ +TV+ L ++Q +++Y +++ +
Sbjct: 893 LSVYLEGRFIMKSAQKAKASIEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDRVDI 952
Query: 2958 ---KYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGS 2788
+ R VF+L ++A + + +Y+G ++ E + ++++ ++FGS
Sbjct: 953 ACRRKVRFRGLVFALGQAAPFLAYG----ISMYYGGILVAEERMNYEDIIKVAEALIFGS 1008
Query: 2787 YCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSE-EIKDTFQGIISFKNVLFSY 2611
+ LG+A+ + + AI + D+ + + S + +G I ++NV F Y
Sbjct: 1009 WMLGQALAYAPNVNDAILSAGRLMDLFKRTSTQPNPPQSPYNTVEKSEGDIVYENVGFEY 1068
Query: 2610 PTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNI 2431
PTR P+L+ ++ ++ +ALVG SGSGKST +QLLL YY+ SG +++ G
Sbjct: 1069 PTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEF 1128
Query: 2430 NIKQLRQAMGVVFQEPVLFNTSIEENIRFG---KPDATEQEIIDALKNANAFDFVCNFPD 2260
+ LR +G+V QEPVLF+ +I ENI +G + D + QEII+A K +N +F+ P
Sbjct: 1129 PLDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISALPQ 1188
Query: 2259 GIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASI 2080
G T +G+ +QLSGGQKQRIAIAR LVRNP+IL+LDEATSALD ESE +VQ+AL +A
Sbjct: 1189 GYDTRLGKT-SQLSGGQKQRIAIARALVRNPKILILDEATSALDLESEKVVQQALDEARS 1247
Query: 2079 GRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMS 1918
GRT + +AHRL+T+RNA+ I V+++G +VE G H +L+A+N +Y NL Q +S
Sbjct: 1248 GRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELMALNKIYANLYLMQQVS 1301
>gi|22331385|ref|NP_683599.1| P-glycoprotein, putative [Arabidopsis
thaliana]
Length = 1221
Score = 643 bits (1659), Expect = 0.0
Identities = 415/1239 (33%), Positives = 672/1239 (53%), Gaps = 30/1239 (2%)
Frame = -1
Query: 3657 LLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFESDMN 3478
+L LG++ ++ G P + G + N I + + HA M
Sbjct: 20 VLMGLGLIGAVGDGFITPIIFFITG-------LLLNDIGDSSFGDKTFMHAI------MK 66
Query: 3477 RVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMSTGHLS 3298
V L ++ G + ++ FVG+ A +R +Y+ +LR+D+ YFD T
Sbjct: 67 NAVALLYVAGASL---------VICFVGERQASRMREKYLRAVLRQDVGYFDLHVTSTSD 117
Query: 3297 IVLNDNMERF--REVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGL 3124
++ + + + ++V +EK+ + + FV I+ F WRL G F +++ GL
Sbjct: 118 VITSVSSDTLVIQDVLSEKLPNFLMSASAFVASYIVGFIMLWRLTIVGFPFFILLLIPGL 177
Query: 3123 LDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALN 2944
+ + + K E + AGSIA QA+ +TV + +++ + +++ L+ K L
Sbjct: 178 MCGRALINISRKIREEYNEAGSIAEQAISLVRTVYAFGSERKMISKFSAALEGSVKLGLR 237
Query: 2943 RAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEAIL 2764
+ ++ ++ T A+ + ++G+ M+ + G + ++ I +G LG +
Sbjct: 238 QGIAKGIAIGSNGV-TYAIWGFMTWYGSRMVMYHGAKGGTIFAVIICITYGGTSLGRGLS 296
Query: 2763 HISRLASAIPLTVPIADIL-----LDSDATADEFFSEEIKDTFQGIISFKNVLFSYPTRP 2599
++ + A+ I +++ +DSD + + + +G + FK+V F Y +RP
Sbjct: 297 NLKYFSEAVVAGERIIEVIKRVPDIDSDNPRGQ-----VLENIKGEVQFKHVKFMYSSRP 351
Query: 2598 DVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQ 2419
+ P+ ++ + G+ +ALVG SGSGKSTVI LL +Y+ G I IDG I + +K
Sbjct: 352 ETPIFDDLCLRIPSGKSVALVGGSGSGKSTVISLLQRFYDPIVGEILIDGVSIKKLQVKW 411
Query: 2418 LRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVG 2239
LR MG+V QEP LF TSIEENI FGK DA+ E+++A K++NA DF+ FP G KT VG
Sbjct: 412 LRSQMGLVSQEPALFATSIEENILFGKEDASFDEVVEAAKSSNAHDFISQFPLGYKTQVG 471
Query: 2238 ERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVV 2059
ERG Q+SGGQKQRI+IAR ++++P +LLLDEATSALD+ESE +VQEAL A+IGRTTIV+
Sbjct: 472 ERGVQMSGGQKQRISIARAIIKSPTLLLLDEATSALDSESERVVQEALDNATIGRTTIVI 531
Query: 2058 AHRLSTIRNANKIIVMEKGEIVEVGDHKQLIA-MNGVYNNLVQTQLMSTNYEKMNENEER 1882
AHRLSTIRN + I V + G+IVE G H++L+ ++G Y +LV+ Q+M E+ N+N
Sbjct: 532 AHRLSTIRNVDVICVFKNGQIVETGSHEELMENVDGQYTSLVRLQIMEN--EESNDNVSV 589
Query: 1881 VTRQSSHSDFP-----SNEISHQ---KIDQEDDYVKKLIAEIKEEGAKKSNICEIIKYCR 1726
R+ S+F S+ +S Q + L I ++ KK + ++ +
Sbjct: 590 SMREGQFSNFNKDVKYSSRLSIQSRSSLFATSSIDTNLAGSIPKD--KKPSFKRLMAMNK 647
Query: 1725 SEYCILFIAVLGSAIQGIYYPL---SSQLMIKSYEAYAFDKDEMLSKSHFWALSILFLAF 1555
E+ L + + G +P+ +S M+ Y + DEM K+ + L + LA
Sbjct: 648 PEWKHALYGCLSAVLYGALHPIYAYASGSMVSVY--FLTSHDEMKEKTRIYVLLFVGLAV 705
Query: 1554 TRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSN 1375
+ Q Y F E L+ ++R L++ +++D+ +++ + +RL D++
Sbjct: 706 LCFLISIIQQYSFAYMGEYLTKRIRENILSKLLTFEVSWFDEDENSSGSICSRLAKDANV 765
Query: 1374 VTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVE 1195
V + V +R+ ++ T+ A+ +A + SWK+S+ ++ P++ + + V +++
Sbjct: 766 VRSLVGERVSLLVQTISAVSVACTLGLAISWKLSIVMIAIQPVV-VGCFYTQRIVLKSIS 824
Query: 1194 EDSI-AFEKSNRAAIEALENVRTVRALNMENRVILLVT-----SHLQKIRNSYFKRAVIQ 1033
+ +I A ++S++ A EA+ N+RT+ A + + R++ L+ + IR S+ V+
Sbjct: 825 KKAIKAQDESSKLAAEAVSNIRTITAFSSQERILKLLKMVQEGPQRENIRQSWLAGIVLA 884
Query: 1032 GTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDH 853
+ + C+ A+++ +G L++ +I + + + T A A D
Sbjct: 885 TSRSLMTCTS-----ALNYWYGARLIIDGKITSKAFFELFILFVSTGRVIADAGAMTMDL 939
Query: 852 RKAIHAAGLIFHLFTYPAIMPYDSSQG--KRNIKNGEIELKNVSFEYAQRSDKMILDGVS 679
K A G +F + + + G +NIK G+I+ NV F Y R D +I S
Sbjct: 940 AKGSDAVGSVFAVLDRYTNIEPEKPDGFVPQNIK-GQIKFVNVDFAYPTRPDVIIFKNFS 998
Query: 678 LKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVS 499
+ + G++ A+VGPSGSGKSTII L+ERFY + G VKID ++ +L LR+ + LVS
Sbjct: 999 IDIDEGKSTAIVGPSGSGKSTIIGLIERFYDPLKGIVKIDGRDIRSYHLRSLRQHIGLVS 1058
Query: 498 QEPVLFNCSIKENFLF-GISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLS 322
QEP+LF +I+EN ++ G S + EI +A K ANA F+ G DT G+RG QLS
Sbjct: 1059 QEPILFAGTIRENIMYGGASDKIDESEIIEAAKAANAHDFIVTLSDGYDTYCGDRGVQLS 1118
Query: 321 GGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTV 142
GGQKQRIAIARA+L+NP VLLLDEATSALD+ SE++VQ+AL ++VV+AHRLST+
Sbjct: 1119 GGQKQRIAIARAVLKNPSVLLLDEATSALDNQSERMVQDALGRLMVGRTSVVIAHRLSTI 1178
Query: 141 VNADSIAVLKNGKVAEQGTHEELLRK--RSIYWRLVQKQ 31
N D+I VL GKV E GTH LL K +Y+ LV Q
Sbjct: 1179 QNCDTITVLDKGKVVECGTHSSLLAKGPTGVYFSLVSLQ 1217
>gi|15228506|ref|NP_189528.1| multidrug resistance P-glycoprotein,
putative [Arabidopsis thaliana]
gi|9294227|dbj|BAB02129.1| P-glycoprotein; multi-drug resistance
related; ABC transporter-like protein [Arabidopsis
thaliana]
Length = 1252
Score = 643 bits (1658), Expect = 0.0
Identities = 400/1229 (32%), Positives = 650/1229 (52%), Gaps = 16/1229 (1%)
Frame = -1
Query: 3669 RYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFE 3490
+++ LL F+G + +I+ G P G+ + N +D + H
Sbjct: 35 KFDYLLMFVGSLGAIVHGSSMPVFFLLFGQ-------MVNGFGKNQMDLHQMVH------ 81
Query: 3489 SDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFD-GMS 3313
+++R L F +G + + + + G+ +R++Y+ +L++D+ +FD
Sbjct: 82 -EVSRYSLYFVYLGLVVCFSSYAEIACWMYSGERQVAALRKKYLEAVLKQDVGFFDTDAR 140
Query: 3312 TGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVL 3133
TG + ++ + ++ +EK+ I L+ F+ G ++ F + W+LA GI
Sbjct: 141 TGDIVFSVSTDTLLVQDAISEKVGNFIHYLSTFLAGLVVGFVSAWKLALLSVAVIPGIAF 200
Query: 3132 SGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKY 2953
+G L ++ K E +NAG IA QA+ +TV S G+ + + Y++ ++ K
Sbjct: 201 AGGLYAYTLTGITSKSRESYANAGVIAEQAIAQVRTVYSYVGESKALNAYSDAIQYTLKL 260
Query: 2952 ALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGE 2773
L Y ++ ++ I G + G ++ + G LG+
Sbjct: 261 GYKAGMAKGLGLGCTYGIACMSWALVFWYAGVFIRNGQTDGGKAFTAIFSAIVGGMSLGQ 320
Query: 2772 AILHISRLASAIPLTVPIADILLDSDATADEFFSEEIKDTFQGIISFKNVLFSYPTRPDV 2593
+ ++ + + +I+ + + D G I FK+V FSYP+RPDV
Sbjct: 321 SFSNLGAFSKGKAAGYKLMEIINQRPTIIQDPLDGKCLDQVHGNIEFKDVTFSYPSRPDV 380
Query: 2592 PVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLR 2413
+ + + G+ +A+VG SGSGKSTV+ L+ +Y+ +SG+I +DG +I + +K LR
Sbjct: 381 MIFRNFNIFFPSGKTVAVVGGSGSGKSTVVSLIERFYDPNSGQILLDGVEIKTLQLKFLR 440
Query: 2412 QAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGER 2233
+ +G+V QEP LF T+I ENI +GKPDAT E+ A ANA F+ P G T VGER
Sbjct: 441 EQIGLVNQEPALFATTILENILYGKPDATMVEVEAAASAANAHSFITLLPKGYDTQVGER 500
Query: 2232 GAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAH 2053
G QLSGGQKQRIAIAR ++++P+ILLLDEATSALD SE IVQEAL + +GRTT+VVAH
Sbjct: 501 GVQLSGGQKQRIAIARAMLKDPKILLLDEATSALDASSESIVQEALDRVMVGRTTVVVAH 560
Query: 2052 RLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLM--STNYEKMNENEERV 1879
RL TIRN + I V+++G++VE G H++LIA +G Y +L++ Q M + ++ + R
Sbjct: 561 RLCTIRNVDSIAVIQQGQVVETGTHEELIAKSGAYASLIRFQEMVGTRDFSNPSTRRTRS 620
Query: 1878 TRQSSHSDFPS--------NEISHQKIDQEDDYVKKLI-AEI-KEEGAKKSNICEIIKYC 1729
TR S S +S+ D ++ + AE ++ A ++ ++K
Sbjct: 621 TRLSHSLSTKSLSLRSGSLRNLSYSYSTGADGRIEMISNAETDRKTRAPENYFYRLLKLN 680
Query: 1728 RSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAF-DKDEMLSKSHFWALSILFLAFT 1552
E+ + +GS + G P + +M E + + D D M K+ + +
Sbjct: 681 SPEWPYSIMGAVGSILSGFIGPTFAIVMSNMIEVFYYTDYDSMERKTKEYVFIYIGAGLY 740
Query: 1551 RPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNV 1372
Q+YFF E L+ ++R M ++ ++D+ H ++ ++ RL D+++V
Sbjct: 741 AVGAYLIQHYFFSIMGENLTTRVRRMMLSAILRNEVGWFDEDEHNSSLIAARLATDAADV 800
Query: 1371 TAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEE 1192
+A+ +R+ ++ + ++L + I++F W++SL +L PLL LA + + +
Sbjct: 801 KSAIAERISVILQNMTSLLTSFIVAFIVEWRVSLLILGTFPLLVLANFAQQLSLKGFAGD 860
Query: 1191 DSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFA 1012
+ A K++ A E + N+RTV A N +++++ L L+ + R+ G G +
Sbjct: 861 TAKAHAKTSMIAGEGVSNIRTVAAFNAQSKILSLFCHELRVPQKRSLYRSQTSGFLFGLS 920
Query: 1011 CSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAA 832
+ A+ +G LV + V + L +TA+ V+ P+ + A
Sbjct: 921 QLALYGSEALILWYGAHLVSKGVSTFSKVIKVFVVLVITANSVAETVSLAPEIIRGGEAV 980
Query: 831 GLIFH-LFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRT 655
G +F L I P D+ G+IE ++V F Y R D M+ +L++ AG +
Sbjct: 981 GSVFSVLDRQTRIDPDDADADPVETIRGDIEFRHVDFAYPSRPDVMVFRDFNLRIRAGHS 1040
Query: 654 LALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNC 475
ALVG SGSGKS++I+++ERFY + G+V ID +++ +NL LR + LV QEP LF
Sbjct: 1041 QALVGASGSGKSSVIAMIERFYDPLAGKVMIDGKDIRRLNLKSLRLKIGLVQQEPALFAA 1100
Query: 474 SIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAI 295
+I +N +G A++ E+ A + ANA F+S P+G T VGERG QLSGGQKQRIAI
Sbjct: 1101 TIFDNIAYG-KDGATESEVIDAARAANAHGFISGLPEGYKTPVGERGVQLSGGQKQRIAI 1159
Query: 294 ARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVL 115
ARA+L+NP VLLLDEATSALD++SE V+Q AL+ +TVVVAHRLST+ D I V+
Sbjct: 1160 ARAVLKNPTVLLLDEATSALDAESECVLQEALERLMRGRTTVVVAHRLSTIRGVDCIGVI 1219
Query: 114 KNGKVAEQGTHEELL-RKRSIYWRLVQKQ 31
++G++ EQG+H EL+ R Y RL+Q Q
Sbjct: 1220 QDGRIVEQGSHSELVSRPEGAYSRLLQLQ 1248
>gi|24324262|gb|AAN28720.2| MDR-like p-glycoprotein [Arabidopsis
thaliana]
Length = 1252
Score = 643 bits (1658), Expect = 0.0
Identities = 400/1229 (32%), Positives = 650/1229 (52%), Gaps = 16/1229 (1%)
Frame = -1
Query: 3669 RYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFE 3490
+++ LL F+G + +I+ G P G+ + N +D + H
Sbjct: 35 KFDYLLMFVGSLGAIVHGSSMPVFFLLFGQ-------MVNGFGKNQMDLHQMVH------ 81
Query: 3489 SDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFD-GMS 3313
+++R L F +G + + + + G+ +R++Y+ +L++D+ +FD
Sbjct: 82 -EVSRYSLYFVYLGLVVCFSSYAEIACWMYSGERQVAALRKKYLEAVLKQDVGFFDTDAR 140
Query: 3312 TGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVL 3133
TG + ++ + ++ +EK+ I L+ F+ G ++ F + W+LA GI
Sbjct: 141 TGDIVFSVSTDTLLVQDAISEKVGNFIHYLSTFLAGLVVGFVSAWKLALLSVAVIPGIAF 200
Query: 3132 SGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKY 2953
+G L ++ K E +NAG IA QA+ +TV S G+ + + Y++ ++ K
Sbjct: 201 AGGLYAYTLTGITSKSRESYANAGVIAEQAIAQVRTVYSYVGESKALNAYSDAIQYTLKL 260
Query: 2952 ALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGE 2773
L Y ++ ++ I G + G ++ + G LG+
Sbjct: 261 GYKAGMAKGLGLGCTYGIACMSWALVFWYAGVFIRNGQTDGGKAFTAIFSAIVGGMSLGQ 320
Query: 2772 AILHISRLASAIPLTVPIADILLDSDATADEFFSEEIKDTFQGIISFKNVLFSYPTRPDV 2593
+ ++ + + +I+ + + D G I FK+V FSYP+RPDV
Sbjct: 321 SFSNLGAFSKGKAAGYKLMEIINQRPTIIQDPLDGKCLDQVHGNIEFKDVTFSYPSRPDV 380
Query: 2592 PVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLR 2413
+ + + G+ +A+VG SGSGKSTV+ L+ +Y+ +SG+I +DG +I + +K LR
Sbjct: 381 MIFRNFNIFFPSGKTVAVVGGSGSGKSTVVSLIERFYDPNSGQILLDGVEIKTLQLKFLR 440
Query: 2412 QAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGER 2233
+ +G+V QEP LF T+I ENI +GKPDAT E+ A ANA F+ P G T VGER
Sbjct: 441 EQIGLVNQEPALFATTILENILYGKPDATMVEVEAAASAANAHSFITLLPKGYDTQVGER 500
Query: 2232 GAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAH 2053
G QLSGGQKQRIAIAR ++++P+ILLLDEATSALD SE IVQEAL + +GRTT+VVAH
Sbjct: 501 GVQLSGGQKQRIAIARAMLKDPKILLLDEATSALDASSESIVQEALDRVMVGRTTVVVAH 560
Query: 2052 RLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLM--STNYEKMNENEERV 1879
RL TIRN + I V+++G++VE G H++LIA +G Y +L++ Q M + ++ + R
Sbjct: 561 RLCTIRNVDSIAVIQQGQVVETGTHEELIAKSGAYASLIRFQEMVGTRDFSNPSTRRTRS 620
Query: 1878 TRQSSHSDFPS--------NEISHQKIDQEDDYVKKLI-AEI-KEEGAKKSNICEIIKYC 1729
TR S S +S+ D ++ + AE ++ A ++ ++K
Sbjct: 621 TRLSHSLSTKSLSLRSGSLRNLSYSYSTGADGRIEMISNAETDRKTRAPENYFYRLLKLN 680
Query: 1728 RSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAF-DKDEMLSKSHFWALSILFLAFT 1552
E+ + +GS + G P + +M E + + D D M K+ + +
Sbjct: 681 SPEWPYSIMGAVGSILSGFIGPTFAIVMSNMIEVFYYTDYDSMERKTKEYVFIYIGAGLY 740
Query: 1551 RPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNV 1372
Q+YFF E L+ ++R M ++ ++D+ H ++ ++ RL D+++V
Sbjct: 741 AVGAYLIQHYFFSIMGENLTTRVRRMMLSAILRNEVGWFDEDEHNSSLIAARLATDAADV 800
Query: 1371 TAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEE 1192
+A+ +R+ ++ + ++L + I++F W++SL +L PLL LA + + +
Sbjct: 801 KSAIAERISVILQNMTSLLTSFIVAFIVEWRVSLLILGTFPLLVLANFAQQLSLKGFAGD 860
Query: 1191 DSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFA 1012
+ A K++ A E + N+RTV A N +++++ L L+ + R+ G G +
Sbjct: 861 TAKAHAKTSMIAGEGVSNIRTVAAFNAQSKILSLFCHELRVPQKRSLYRSQTSGFLFGLS 920
Query: 1011 CSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAA 832
+ A+ +G LV + V + L +TA+ V+ P+ + A
Sbjct: 921 QLALYGSEALILWYGAHLVSKGVSTFSKVIKVFVVLVITANSVAETVSLAPEIIRGGEAV 980
Query: 831 GLIFH-LFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRT 655
G +F L I P D+ G+IE ++V F Y R D M+ +L++ AG +
Sbjct: 981 GSVFSVLDRQTRIDPDDADADPVETIRGDIEFRHVDFAYPSRPDVMVFRDFNLRIRAGHS 1040
Query: 654 LALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNC 475
ALVG SGSGKS++I+++ERFY + G+V ID +++ +NL LR + LV QEP LF
Sbjct: 1041 QALVGASGSGKSSVIAMIERFYDLLAGKVMIDGKDIRRLNLKSLRLKIGLVQQEPALFAA 1100
Query: 474 SIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAI 295
+I +N +G A++ E+ A + ANA F+S P+G T VGERG QLSGGQKQRIAI
Sbjct: 1101 TIFDNIAYG-KDGATESEVIDAARAANAHGFISGLPEGYKTPVGERGVQLSGGQKQRIAI 1159
Query: 294 ARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVL 115
ARA+L+NP VLLLDEATSALD++SE V+Q AL+ +TVVVAHRLST+ D I V+
Sbjct: 1160 ARAVLKNPTVLLLDEATSALDAESECVLQEALERLMRGRTTVVVAHRLSTIRGVDCIGVI 1219
Query: 114 KNGKVAEQGTHEELL-RKRSIYWRLVQKQ 31
++G++ EQG+H EL+ R Y RL+Q Q
Sbjct: 1220 QDGRIVEQGSHSELVSRPEGAYSRLLQLQ 1248
>gi|9294577|dbj|BAB02858.1| multidrug resistance p-glycoprotein; ABC
transporter-like protein [Arabidopsis thaliana]
Length = 1262
Score = 642 bits (1655), Expect = 0.0
Identities = 415/1239 (33%), Positives = 671/1239 (53%), Gaps = 30/1239 (2%)
Frame = -1
Query: 3657 LLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFESDMN 3478
+L LG++ ++ G P + G + N I + + HA M
Sbjct: 53 VLMGLGLIGAVGDGFITPIIFFITG-------LLLNDIGDSSFGDKTFMHAI------MK 99
Query: 3477 RVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMSTGHLS 3298
V L ++ G A F++ G+ A +R +Y+ +LR+D+ YFD T
Sbjct: 100 NAVALLYVAG-ASLVICFVEGYCWTRTGERQASRMREKYLRAVLRQDVGYFDLHVTSTSD 158
Query: 3297 IVLNDNMERF--REVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGL 3124
++ + + + ++V +EK+ + + FV I+ F WRL G F +++ GL
Sbjct: 159 VITSVSSDTLVIQDVLSEKLPNFLMSASAFVASYIVGFIMLWRLTIVGFPFFILLLIPGL 218
Query: 3123 LDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALN 2944
+ + + K E + AGSIA QA+ +TV + +++ + +++ L+ K L
Sbjct: 219 MCGRALINISRKIREEYNEAGSIAEQAISLVRTVYAFGSERKMISKFSAALEGSVKLGLR 278
Query: 2943 RAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEAIL 2764
+ ++ ++ T A+ + ++G+ M+ + G + ++ I +G LG +
Sbjct: 279 QGIAKGIAIGSNGV-TYAIWGFMTWYGSRMVMYHGAKGGTIFAVIICITYGGTSLGRGLS 337
Query: 2763 HISRLASAIPLTVPIADIL-----LDSDATADEFFSEEIKDTFQGIISFKNVLFSYPTRP 2599
++ + A+ I +++ +DSD + + + +G + FK+V F Y +RP
Sbjct: 338 NLKYFSEAVVAGERIIEVIKRVPDIDSDNPRGQ-----VLENIKGEVQFKHVKFMYSSRP 392
Query: 2598 DVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQ 2419
+ P+ ++ + G+ +ALVG SGSGKSTVI LL +Y+ G I IDG I + +K
Sbjct: 393 ETPIFDDLCLRIPSGKSVALVGGSGSGKSTVISLLQRFYDPIVGEILIDGVSIKKLQVKW 452
Query: 2418 LRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVG 2239
LR MG+V QEP LF TSIEENI FGK DA+ E+++A K++NA DF+ FP G KT VG
Sbjct: 453 LRSQMGLVSQEPALFATSIEENILFGKEDASFDEVVEAAKSSNAHDFISQFPLGYKTQVG 512
Query: 2238 ERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVV 2059
ERG Q+SGGQKQRI+IAR ++++P +LLLDEATSALD+ESE +VQEAL A+IGRTTIV+
Sbjct: 513 ERGVQMSGGQKQRISIARAIIKSPTLLLLDEATSALDSESERVVQEALDNATIGRTTIVI 572
Query: 2058 AHRLSTIRNANKIIVMEKGEIVEVGDHKQLIA-MNGVYNNLVQTQLMSTNYEKMNENEER 1882
AHRLSTIRN + I V + G+IVE G H++L+ ++G Y +LV+ Q+M E+ N+N
Sbjct: 573 AHRLSTIRNVDVICVFKNGQIVETGSHEELMENVDGQYTSLVRLQIMEN--EESNDNVSV 630
Query: 1881 VTRQSSHSDFP-----SNEISHQ---KIDQEDDYVKKLIAEIKEEGAKKSNICEIIKYCR 1726
R+ S+F S+ +S Q + L I ++ KK + ++ +
Sbjct: 631 SMREGQFSNFNKDVKYSSRLSIQSRSSLFATSSIDTNLAGSIPKD--KKPSFKRLMAMNK 688
Query: 1725 SEYCILFIAVLGSAIQGIYYPL---SSQLMIKSYEAYAFDKDEMLSKSHFWALSILFLAF 1555
E+ L + + G +P+ +S M+ Y + DEM K+ + L + LA
Sbjct: 689 PEWKHALYGCLSAVLYGALHPIYAYASGSMVSVY--FLTSHDEMKEKTRIYVLLFVGLAV 746
Query: 1554 TRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSN 1375
+ Q Y F E L+ ++R L++ +++D+ +++ + +RL D++
Sbjct: 747 LCFLISIIQQYSFAYMGEYLTKRIRENILSKLLTFEVSWFDEDENSSGSICSRLAKDANV 806
Query: 1374 VTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVE 1195
V + V +R+ ++ T+ A+ +A + SWK+S+ ++ P++ + + V +++
Sbjct: 807 VRSLVGERVSLLVQTISAVSVACTLGLAISWKLSIVMIAIQPVV-VGCFYTQRIVLKSIS 865
Query: 1194 EDSI-AFEKSNRAAIEALENVRTVRALNMENRVILLVT-----SHLQKIRNSYFKRAVIQ 1033
+ +I A ++S++ A EA+ N+RT+ A + + R++ L+ + IR S+ V+
Sbjct: 866 KKAIKAQDESSKLAAEAVSNIRTITAFSSQERILKLLKMVQEGPQRENIRQSWLAGIVLA 925
Query: 1032 GTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDH 853
+ + C+ A+++ +G L++ +I + + + T A A D
Sbjct: 926 TSRSLMTCTS-----ALNYWYGARLIIDGKITSKAFFELFILFVSTGRVIADAGAMTMDL 980
Query: 852 RKAIHAAGLIFHLFTYPAIMPYDSSQG--KRNIKNGEIELKNVSFEYAQRSDKMILDGVS 679
K A G +F + + + G +NIK G+I+ NV F Y R D +I S
Sbjct: 981 AKGSDAVGSVFAVLDRYTNIEPEKPDGFVPQNIK-GQIKFVNVDFAYPTRPDVIIFKNFS 1039
Query: 678 LKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVS 499
+ + G++ A+VGPSGSGKSTII L+ERFY + G VKID ++ +L LR+ + LVS
Sbjct: 1040 IDIDEGKSTAIVGPSGSGKSTIIGLIERFYDPLKGIVKIDGRDIRSYHLRSLRQHIGLVS 1099
Query: 498 QEPVLFNCSIKENFLF-GISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLS 322
QEP+LF +I+EN ++ G S + EI +A K ANA F+ G DT G+RG QLS
Sbjct: 1100 QEPILFAGTIRENIMYGGASDKIDESEIIEAAKAANAHDFIVTLSDGYDTYCGDRGVQLS 1159
Query: 321 GGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTV 142
GGQKQRIAIARA+L+NP VLLLDEATSALD+ SE++VQ+AL ++VV+AHRLST+
Sbjct: 1160 GGQKQRIAIARAVLKNPSVLLLDEATSALDNQSERMVQDALGRLMVGRTSVVIAHRLSTI 1219
Query: 141 VNADSIAVLKNGKVAEQGTHEELLRK--RSIYWRLVQKQ 31
N D+I VL GKV E GTH LL K +Y+ LV Q
Sbjct: 1220 QNCDTITVLDKGKVVECGTHSSLLAKGPTGVYFSLVSLQ 1258
>gi|34913544|ref|NP_918119.1| putative multidrug resistance protein
[Oryza sativa (japonica cultivar-group)]
gi|20146377|dbj|BAB89158.1| putative multidrug resistance protein
[Oryza sativa (japonica cultivar-group)]
Length = 1184
Score = 641 bits (1654), Expect = 0.0
Identities = 410/1193 (34%), Positives = 637/1193 (53%), Gaps = 51/1193 (4%)
Frame = -1
Query: 3462 FFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDG-MSTGHLSIVLN 3286
F +G LQ S G+ A +R Y+ +LR+DI++FD M+TG L ++
Sbjct: 3 FIYLGVGAGLVSALQVSCWTITGERQAARIRALYLKAILRQDIAFFDKEMNTGQLVERMS 62
Query: 3285 DNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLLDSWGK 3106
+ ++ EK I LL+ F G I+AF W LA + ++G + S
Sbjct: 63 GDAFLIQDAIGEKAGKCIQLLSTFFGGFIIAFVRGWLLALVMLSSIPPVAVAGAIMSRLM 122
Query: 3105 MKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNRAFVFS 2926
+K + +AG + Q +G +TV + NG+++ + Y + +K + AL + +
Sbjct: 123 VKLTIRMQAKYGDAGIVVEQTIGAIRTVVAFNGEKKAINTYNKFIKKAYESALQQGVING 182
Query: 2925 LSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEAILHISRLA 2746
L + + + +++G+ +I E G+V+ ++ I+ + LG A I+ LA
Sbjct: 183 LGLGSIISVFFSSYGLAVWYGSRLIVERGYNGGIVINVIMAIMISAMSLGHATSSITALA 242
Query: 2745 SAIPLTVPIADIL-----LDSDATADEFFSEEIKDTFQGIISFKNVLFSYPTRPDVPVLK 2581
+ + +D+ T + F E++K G + KNV FSYP+RP+ V
Sbjct: 243 GGQGAAYRLFRTIERQPDIDACCTTGDIF-EDVK----GDVELKNVYFSYPSRPEHLVFD 297
Query: 2580 EISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAMG 2401
S V G +ALVG SGSGKSTVI L+ +Y+ SG + IDG DI IN+ +R+ +G
Sbjct: 298 GFSLQVPSGTRMALVGESGSGKSTVISLVERFYDPQSGEVLIDGVDIRRINLGSIRRKIG 357
Query: 2400 VVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGERGAQL 2221
+V QEPVLF +I ENI +GK D T +EI A++ ANA F+ P+G++T+VGERG QL
Sbjct: 358 LVSQEPVLFAGTIRENITYGKEDPTLEEINRAIELANAAKFIDKLPNGLETMVGERGIQL 417
Query: 2220 SGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHRLST 2041
SGGQKQRIAIAR +++NPRILLLDEATSALD ESE +VQEAL K + RTTI+VAHRLST
Sbjct: 418 SGGQKQRIAIARVIIKNPRILLLDEATSALDMESERVVQEALNKVMLERTTIIVAHRLST 477
Query: 2040 IRNANKIIVMEKGEIVEVGDHKQLIAM-NGVYNNLVQTQLMSTNYEKMNENEERVTRQSS 1864
++NA+ I V++ G++VE G H++L+ G Y L+ Q N++ + + R
Sbjct: 478 VKNADMISVLQHGKLVEQGSHEELMKKPEGSYCKLIHLQETRQEAVAPNDDPDMIIRNDF 537
Query: 1863 HSDFPSNEISHQKID-------------------------------QEDDYVKKLIAEIK 1777
S +++ Q I +D ++K+ ++
Sbjct: 538 DSRIINSKTRSQNISFRKSTSKSSSFGHSGTHPFTSTCDLSDPMEVHDDQHIKETTDKMS 597
Query: 1776 EEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLS 1597
+K++I + + E +L + + +A+ G+ +P+ L+ + + + + E+L
Sbjct: 598 N-CQEKASILRLFSLNKPEAFVLALGSITAAMHGVIFPVFGILVSSAIKMFYEPRSELLK 656
Query: 1596 KSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHT 1417
S L + + I +Y+ FG KL ++RS++FK +M +++D P ++
Sbjct: 657 NSRLLGSMFPVLGISTFLLIPTEYFLFGLAGGKLVERIRSLTFKSVMYQEISWFDKPENS 716
Query: 1416 ATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYL 1237
+ + RL+ D+ NV V D L TL I+ ++ +WK++L + + PL+
Sbjct: 717 SGSIGARLSTDALNVKRLVGDNLALNFQTLSTIISGFTIAMVANWKLALIITVVVPLVGF 776
Query: 1236 AGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNS 1057
Y F+ + FE + + A EA+ +RT+ + E QK+ N+
Sbjct: 777 QAYAQMMFLKGFNKNAKSMFEDATQVATEAVGGIRTITSFCAE-----------QKVMNA 825
Query: 1056 YFKRA---VIQGTANG--------FACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLM 910
Y K+ +IQG +G F+ ++F YA+ F G V + + + V
Sbjct: 826 YEKKCASPIIQGIRDGVVGALGFGFSFLVFYFAYALCFYVGAKFVHQGTATFAEVFRVFF 885
Query: 909 TLSMTASYAGSAVAYLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGKRNIK-NGEIELKN 733
L + + A + R+ + +F + + + + +G G+IE +N
Sbjct: 886 VLVLGINEISRTSAIGSESRRVNESVVSVFKILDRKSKIDSSNDEGVVIASVRGDIEFQN 945
Query: 732 VSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEE 553
V F+Y R + I +SL +P+G+T ALVG SGSGKST+ISLLERFY G + D
Sbjct: 946 VCFKYPLRPNVQIFKDLSLSIPSGKTAALVGESGSGKSTVISLLERFYEPDAGRILFDGV 1005
Query: 552 NVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQ 373
+ + + LR + LV+QEPVLFN +I+ N +G +AS+ EI A + ANA F+S
Sbjct: 1006 ELETLKVSWLRLQIGLVAQEPVLFNDTIRANIAYGKQGDASEEEIIAAAEAANAHQFISG 1065
Query: 372 FPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDT 193
P G +T+VGERG QLSGGQKQR+AIARA++++PKVLLLDEATSALDS+SE+VVQ ALD
Sbjct: 1066 LPDGYNTIVGERGIQLSGGQKQRVAIARAVIKDPKVLLLDEATSALDSESERVVQEALDR 1125
Query: 192 ASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLR-KRSIYWRLVQ 37
+TVVVAHRLST+ AD I VL+NG + E+G HEEL++ K IY LV+
Sbjct: 1126 EVVGRTTVVVAHRLSTIKGADIIGVLENGTIVEKGRHEELMQIKGGIYSSLVE 1178
>gi|50543630|ref|XP_499981.1| hypothetical protein [Yarrowia
lipolytica]
gi|49645846|emb|CAG83910.1| unnamed protein product [Yarrowia
lipolytica CLIB99]
Length = 1254
Score = 641 bits (1654), Expect = 0.0
Identities = 410/1249 (32%), Positives = 658/1249 (51%), Gaps = 28/1249 (2%)
Frame = -1
Query: 3684 IKCTTRYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHA 3505
++ T +K + VFS G C P + G + V+ + T P + H
Sbjct: 36 LRYATPLDKAEILVSYVFSACAGACLPLFTLIFGSMTNEFVRYF--VEGAT--PAEFGH- 90
Query: 3504 YKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYF 3325
+N + F + F F FL+ + +G+ +R Y+ ++R++I +F
Sbjct: 91 ------QINYLARYFIYLFAGIFAFSFLETYMHVQMGEKLTGRIRAHYLEAIMRQNIGFF 144
Query: 3324 DGMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSF 3145
D + G ++ + + +E +EK LI++ + + I+ F W+L F
Sbjct: 145 DKVGAGEITNRITTDTNLIQEGISEKAGLIVSSIAAIISAFIIGFIKSWKLTLIMMSSFF 204
Query: 3144 GIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKN 2965
++ + + +K + + A S+A + LG + V + Q + ++Y + L
Sbjct: 205 ALLFAMTTAVYFVVKFAKLAIVSDAKASSVAEEVLGAIRNVVAFGTQDRLTQKYDDRLVV 264
Query: 2964 GEKYALNRAFVFSLSRSADYFFTNALNFVILYF-GANMIYEGTIEPGVVVRILYYILFGS 2788
KY + R S + A + LN+ + ++ G+ ++ G + G ++ +L+ ++ G+
Sbjct: 265 SMKYHIFRGRG-SAAAIASVWTIAYLNYALSFWEGSRLVSWGQVNVGNIMTVLFAVMIGA 323
Query: 2787 YCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFKNVLFSY 2611
+G ++ + SAI I + + D D F + K D G I ++V F Y
Sbjct: 324 VMVGNVAPNLQAMGSAIASGQKIFETI-DRVPPIDSFSDKGQKLDQVHGHIQLEHVNFRY 382
Query: 2610 PTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNI 2431
P+RPDV VL + S ++ G+ +ALVGASGSGKST+I +L +Y I G+++IDG DI ++
Sbjct: 383 PSRPDVSVLHDFSLEIKPGQTVALVGASGSGKSTIIGILERFYEILGGKVTIDGVDISSL 442
Query: 2430 NIKQLRQAMGVVFQEPVLFNTSIEENIRFG---------KPDATEQEIIDALKNANAFDF 2278
N++ LRQ + +V QEP LF SI ENI +G P+ Q + DA + ANA+DF
Sbjct: 443 NVRWLRQQLALVSQEPTLFGVSIYENIAYGLIGTPHENADPEKKRQLVEDAARQANAYDF 502
Query: 2277 VCNFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEA 2098
+ + DG +T VG+RG LSGGQKQRIAIAR +VR P+ILLLDEATSALD +SE IVQ+A
Sbjct: 503 IQDLTDGFETNVGDRGFLLSGGQKQRIAIARAIVREPKILLLDEATSALDTKSEGIVQDA 562
Query: 2097 LQKASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMS 1918
L KA+ RTTIV+AHRLST++NA+ I+VM KG IVE G H +LI G+Y +LV +Q +
Sbjct: 563 LDKAAADRTTIVIAHRLSTVKNADLIVVMNKGSIVEQGTHHELIEQKGMYFSLVNSQTI- 621
Query: 1917 TNYEKMNENEERVTRQSSHSDFPSNEISHQKIDQEDDYVKKLIAEIKEE-GAKKSNICEI 1741
M +N++ SD +++ + + +E +EE K+ I E+
Sbjct: 622 -----MKQNDD-------GSDTAADDKLEEDVVAIQSLTMSSFSEDEEEYNTKEQGIIEM 669
Query: 1740 IK----YCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKD---EMLSKSHFW 1582
I+ Y + E +L I + + GI YP + + K EA+ M S + +
Sbjct: 670 IRFVYSYNKEETTLLLIGGACAFVGGIGYPGMAVIFAKCIEAFMTPPSGYPHMRSLINTY 729
Query: 1581 ALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLS 1402
+A + + + E+L KLR FK + + F+D +T L+
Sbjct: 730 TGLFFMIAMIEMVAFYVEISILTLAGERLVRKLRLAVFKQFLRMDIGFFDREENTTGSLT 789
Query: 1401 NRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCN 1222
+ L D+ NV G +++++V ++ ++S ++W+M L P+L G+C
Sbjct: 790 SNLGKDAHNVRGLSGTTFGQILVSIVTVVAGFVVSVVFNWRMGLICGACIPILIGCGFCR 849
Query: 1221 DNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILL----VTSHLQKIRNSY 1054
+ +A+E+S A E +RTV L E +V V +Q +
Sbjct: 850 YYVLTWLNNRAKLAYEQSGSYACENTNAIRTVTTLTREYQVYKTYKESVEGQVQGSKRPI 909
Query: 1053 FKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSA 874
F +++ G + + I ++F +G L+ I P ++ + + + AGS
Sbjct: 910 FFSSILFGLSQSLSP----LIMGLAFWYGGILLKHHTISPFRFFVAFIAIVFGSQSAGSI 965
Query: 873 VAYLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQG----KRNIKNGEIELKNVSFEYAQRS 706
+ PD KA + I ++ + + S QG +++K G IE +NV F Y R
Sbjct: 966 FTFAPDMSKAAGSTRNIMNVLAVEPEIDWWSDQGTKIDPKDVK-GNIEFQNVHFRYPTRM 1024
Query: 705 DKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHH 526
+L G++L + G+ +ALVG SG GKST + LLE FY G++ +D ++ D+N++
Sbjct: 1025 QVPVLRGLNLSIKQGQYVALVGSSGCGKSTTVGLLECFYRPTSGKILLDGLDLADLNINS 1084
Query: 525 LRESVSLVSQEPVLFNCSIKENFLFGISH-NASQLEIDQALKVANAFSFVSQFPQGLDTL 349
RE+V+LV QEP+LF+ +IKEN L G + + + +A + +N F+ P+G DT+
Sbjct: 1085 YREAVALVQQEPILFSGTIKENILLGTQDPDVTDEVVYEAARKSNIHDFIMSLPEGYDTV 1144
Query: 348 VGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTV 169
G +G+ LSGGQKQRIAIARA++RNPK+LLLDEATSALDS+SEKVVQ ALD A++ +T+
Sbjct: 1145 CGSKGSLLSGGQKQRIAIARALIRNPKILLLDEATSALDSESEKVVQAALDAAAKGRTTI 1204
Query: 168 VVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQ 22
+AHRLST+ NAD I V +NG V E GTH++LL RS Y+ LV+ Q ++
Sbjct: 1205 AIAHRLSTIQNADVIFVFENGVVLESGTHQQLLANRSKYYELVKLQALE 1253
>gi|422286|pir||S30328 multidrug resistance protein 2 - Entamoeba
histolytica
gi|158973|gb|AAA29113.1| P-glycoprotein-2
Length = 1310
Score = 641 bits (1653), Expect = 0.0
Identities = 425/1265 (33%), Positives = 665/1265 (51%), Gaps = 56/1265 (4%)
Frame = -1
Query: 3657 LLFFLGVVFSILTGMCQPFESYTLGE------TSQVLVKVTNAINNKTIDP---VDLAHA 3505
+L +G+ S+ G+ P + +G+ T+ ++ N DP + H
Sbjct: 52 ILLAVGIFGSVGCGVLTPCQMLVMGDMVDTFNTNDLMKAFPN--QEAMYDPKYYIPFNHE 109
Query: 3504 Y-KLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISY 3328
K +N +VL FL + + N+R Y LLR+D +
Sbjct: 110 VTKTVADTINDLVLKMVCFAIGSGVGSFLMTFCFFVMSERQGINIRMLYFRALLRQDAGW 169
Query: 3327 FDGMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFS 3148
+D +G L+ + ++++ ++ ++K +I T F+ G + F DW L S
Sbjct: 170 YDFHESGELTSRIASDVQQIQDGMSQKFGIIFQTTTSFIAGYAIGFAKDWDLTLVIMSMS 229
Query: 3147 FGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELK 2968
IVLS L + K E + NAG+IA +G +TV SL + + E Y E+++
Sbjct: 230 PFIVLSMTLLAVFATKFTVLGEESLGNAGAIAEATIGNMRTVHSLGQEHEFCEMYNEKIR 289
Query: 2967 NGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEG-----TIEPGVVVRILYY 2803
++Y + + L A FF F + + A+++ G + G V+ +
Sbjct: 290 VVDRYNVLKGLTVGLGLGAVMFFIMGA-FSLGSWYASVVLRGKGGKKNVTAGDVMIVFIC 348
Query: 2802 ILFGSYCLGEAILHISRLASAIPLTVPIADIL-----LDSDATADEFFSEEIKDTFQGII 2638
+L + L + ++ A+A I + +D +TA E +E G I
Sbjct: 349 VLIATQGLSIIAIPLNIFATAKASAYRIYQTIDRIPDIDCRSTAGECPTE-----CNGNI 403
Query: 2637 SFKNVLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRIS 2458
+ ++V F YPTRP +L + ++ G+ +ALVGASG GKST IQL+ Y+ G +
Sbjct: 404 TLEDVQFRYPTRPTKQILGGLDLEIKKGQTVALVGASGCGKSTTIQLVQRNYDPVGGSVK 463
Query: 2457 IDGNDIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDA---TEQEIIDALKNANA 2287
+DG D+ ++NIK LR +G+V QEP+LF +I ENI G D TE+E+I+ K ANA
Sbjct: 464 LDGKDLRDLNIKWLRNQIGLVGQEPILFACTIRENIMLGARDGETPTEEEMIECAKMANA 523
Query: 2286 FDFVCNFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIV 2107
+F+ + P+G T+VGE+GA LSGGQKQRIAIAR L+R P ILLLDEATSALD +SE IV
Sbjct: 524 HEFISHLPEGYDTMVGEKGAALSGGQKQRIAIARALIRKPTILLLDEATSALDTQSEKIV 583
Query: 2106 QEALQKASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQ 1927
Q+AL+KAS GRTTIVVAHRL+T+RNA++I V +GEI+E G H++L+ + G Y LV+ Q
Sbjct: 584 QQALEKASQGRTTIVVAHRLTTVRNASRICVFHQGEIIEQGTHQELMDLKGTYYGLVKRQ 643
Query: 1926 LM--STNYEKMNENEERVTRQSSHSDFPSNEISHQKIDQEDDYVKKLIAEIKEEGAKKSN 1753
M + E + + +++ Q + N+ + +++ D V+KL E E K +
Sbjct: 644 SMEEEVDQETVENDLKKIREQENKEAEEINQHKNTDTNEDPDIVQKLENEYNSEMKKLKH 703
Query: 1752 ------ICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLS-- 1597
+ I+ R E+ + +G G +P + ++ + L+
Sbjct: 704 SNRFVLLRVILDNFRHEWFLSTFGFIGGIGGGAIFPFFTLKIVDLIMCLLSINSDTLTDD 763
Query: 1596 -KSHFWALSILFLAFTRPIFIFFQYY--FFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDP 1426
K + I+ + F+ F Y F K+ ++R + +M +++D
Sbjct: 764 QKDTIKNICIIVVVIGVASFLSFFMYIGLFLSAGFKMIGRVRKDMYHSIMHQNISWFDRK 823
Query: 1425 CHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPL 1246
+ L+ RL +D + + +R+G+VI + I A+ ++F+Y WK+SL V+ P+
Sbjct: 824 ENMVGSLTTRLASDPTTLQGISGERVGNVIHIISTIGFALGIAFYYDWKVSLAVMAVSPV 883
Query: 1245 LYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKI 1066
L + + N A+EKS +EA+E+VRTV++L E + L++
Sbjct: 884 LIVVVFINGKLNSLEACPAQAAYEKSGITLVEAVESVRTVQSLTREEHFYEVFKDALREP 943
Query: 1065 RNSYFKRAVIQGTANGFACSCYFFIYAVS---FKFGTWLVLREE--ILPMDTYLV----- 916
+ +K A + F C ++ F GT+L+ ++ LP+ +++
Sbjct: 944 KIGIYKWAPLLSI---FMCLTTLLTQVMNPYGFYIGTYLIKKKSNYDLPVPDFMIEFSDR 1000
Query: 915 -------LMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFHLF-TYPAIMPYDSSQGKRNI 760
+M + A G+ +PD KA+ AA + + P I Y N
Sbjct: 1001 FEEMQKAIMAVIFAAQAVGNLGNIVPDIGKAVRAAKNTYDVIDRKPTIDCYSEEGETFND 1060
Query: 759 KNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAV 580
GEIE K++ F Y R D +L G+S K+ G+T+ALVG SG GKST + L+ERFY
Sbjct: 1061 VKGEIEFKDICFRYPTRPDNSVLKGISFKVEQGKTVALVGASGCGKSTSVQLIERFYDPT 1120
Query: 579 DGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISH--NASQLEIDQAL 406
G+V +D N+ D+N+H LR + +V QEPVLF S+ +N G+ S +I A
Sbjct: 1121 HGDVLLDGHNIKDLNIHFLRSQIGMVGQEPVLFAESVMDNIRRGVPKGVEVSNEQIYAAA 1180
Query: 405 KVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSD 226
K+ANA F+S P+G +T+VG+RGAQ+SGGQKQRIAIARA++RNPKVLLLDEATSALDS+
Sbjct: 1181 KMANAHDFISAMPEGYNTMVGDRGAQISGGQKQRIAIARALIRNPKVLLLDEATSALDSE 1240
Query: 225 SEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWR 46
SEK+VQ+ALD A++ +T+V+AHRLST+ NAD I V+ G++AE+GTH+ELL + Y+
Sbjct: 1241 SEKIVQDALDKAAKGRTTIVIAHRLSTIQNADQICVIMRGRIAERGTHQELLDLKGFYYT 1300
Query: 45 LVQKQ 31
L +Q
Sbjct: 1301 LAMQQ 1305
Score = 290 bits (741), Expect = 2e-76
Identities = 179/534 (33%), Positives = 287/534 (53%), Gaps = 13/534 (2%)
Frame = -1
Query: 1578 LSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSN 1399
L ++ A + F + F +E+ I +R + F+ L+ +YD H + L++
Sbjct: 123 LKMVCFAIGSGVGSFLMTFCFFVMSERQGINIRMLYFRALLRQDAGWYD--FHESGELTS 180
Query: 1398 RLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCND 1219
R+ +D + + + G + T + + + F W ++L ++ P + L+
Sbjct: 181 RIASDVQQIQDGMSQKFGIIFQTTTSFIAGYAIGFAKDWDLTLVIMSMSPFIVLSMTLLA 240
Query: 1218 NFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAV 1039
F + + + A + N+RTV +L E+ + ++ + + V
Sbjct: 241 VFATKFTVLGEESLGNAGAIAEATIGNMRTVHSLGQEHEFCEMYNEKIRVVD----RYNV 296
Query: 1038 IQGTANGFACSCYFFIYAVSFKFGTW---LVLR-----EEILPMDTYLVLMTLSMTASYA 883
++G G F +F G+W +VLR + + D +V + + +
Sbjct: 297 LKGLTVGLGLGAVMFFIMGAFSLGSWYASVVLRGKGGKKNVTAGDVMIVFICVLIATQ-- 354
Query: 882 GSAVAYLPDHRKAIHAAGLIFHLFTYPAIMPYD--SSQGKRNIK-NGEIELKNVSFEYAQ 712
G ++ +P + A A T I D S+ G+ + NG I L++V F Y
Sbjct: 355 GLSIIAIPLNIFATAKASAYRIYQTIDRIPDIDCRSTAGECPTECNGNITLEDVQFRYPT 414
Query: 711 RSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNL 532
R K IL G+ L++ G+T+ALVG SG GKST I L++R Y V G VK+D +++ D+N+
Sbjct: 415 RPTKQILGGLDLEIKKGQTVALVGASGCGKSTTIQLVQRNYDPVGGSVKLDGKDLRDLNI 474
Query: 531 HHLRESVSLVSQEPVLFNCSIKENFLFGI--SHNASQLEIDQALKVANAFSFVSQFPQGL 358
LR + LV QEP+LF C+I+EN + G ++ E+ + K+ANA F+S P+G
Sbjct: 475 KWLRNQIGLVGQEPILFACTIRENIMLGARDGETPTEEEMIECAKMANAHEFISHLPEGY 534
Query: 357 DTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERL 178
DT+VGE+GA LSGGQKQRIAIARA++R P +LLLDEATSALD+ SEK+VQ AL+ AS+
Sbjct: 535 DTMVGEKGAALSGGQKQRIAIARALIRKPTILLLDEATSALDTQSEKIVQQALEKASQGR 594
Query: 177 STVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQVE 16
+T+VVAHRL+TV NA I V G++ EQGTH+EL+ + Y+ LV++Q ++ E
Sbjct: 595 TTIVVAHRLTTVRNASRICVFHQGEIIEQGTHQELMDLKGTYYGLVKRQSMEEE 648
>gi|48094917|ref|XP_394305.1| similar to ENSANGP00000021663 [Apis
mellifera]
Length = 5485
Score = 640 bits (1651), Expect = 0.0
Identities = 441/1326 (33%), Positives = 669/1326 (50%), Gaps = 79/1326 (5%)
Frame = -1
Query: 3756 NVCKFIKVIVGSTNNFLKKTFGFQIKCTTRYEKLLFFLGVVFSILTGMCQPFESYTLGET 3577
N K + + +T+ L ++ Q + T E +L F G++ LTG+C P + GE
Sbjct: 3706 NKLKLLADELKATDYTLTQSSLDQFRFATCGELMLIFGGLIMGTLTGLCIPISTIQYGEF 3765
Query: 3576 SQVLVKVTNAINNKTIDPVDLAHAY---KLFESDMN---RVVLLF-----FLVGFA---- 3442
+ +LV + N T P + + K+ S+ R+ L+ F V A
Sbjct: 3766 TTLLVD--RNMKNHTSTPTLIMKWFGGGKVLGSNSTYKERMEALYDDSVAFGVSSAALST 3823
Query: 3441 -YFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFD-GMSTGHLSIVLNDN---- 3280
F F ++ VR+ ++ +LR+D++++D ST S + + N
Sbjct: 3824 FQFVFAVFTVDLLNVAASRQIVRVRKMFLRSVLRQDMTWYDINTSTNFASRITDGNNLVN 3883
Query: 3279 --------------------------------------MERFREVFNEKIALIIALLTDF 3214
+++ ++ EK+ + L+ F
Sbjct: 3884 NLRDDAVFCHNGDRRGNHGGFDLEDECKRDRVDGGAKDLDKMKDGIGEKLGVFTYLMVSF 3943
Query: 3213 VIGTILAFYTDWRLACYGTVFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGC 3034
+ I++F W+L + IV++ + + + ++ AGS+A + LG
Sbjct: 3944 ISSIIISFVYGWKLTLVVLSCAPIIVIATAVVAKVQSSLTAQELTAYGQAGSVAEEVLGA 4003
Query: 3033 YKTVSSLNGQQQEVERYTEELKNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANM 2854
+TV + NG+Q+EV RY E+L EK + R + +F + ++G +
Sbjct: 4004 IRTVIAFNGEQKEVNRYAEKLIPAEKTGIKRGMWSGVGGGVMWFIIYISYAIAFWYGVQL 4063
Query: 2853 IYEGTIE------PGVVVRILYYILFGSYCLGEAILHISRLASAIPLTVPIADILLDSDA 2692
I E + P V+V + + +L G+ +G H+ A A I +L D
Sbjct: 4064 ILEDRPKEVKEYTPAVLVIVFFGVLAGAQNMGLTSPHLEAFAVARGSAAAIFQVL-DRVP 4122
Query: 2691 TADEFFSEEIK-DTFQGIISFKNVLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGK 2515
T D E K G I FKNV F YP R DV VL+ ++ + GE +ALVG SG GK
Sbjct: 4123 TIDSLSKEGQKLPAVNGEIEFKNVHFQYPARKDVKVLQGLNLTINRGETVALVGGSGCGK 4182
Query: 2514 STVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKP 2335
ST +QL+ Y+ G++ +DG D+ +N++ LR +GVV QEPVLF+T+I ENIR+G
Sbjct: 4183 STCLQLIQRLYDPHKGQVLLDGVDVSKLNVQWLRSHIGVVGQEPVLFDTTIRENIRYGND 4242
Query: 2334 DATEQEIIDALKNANAFDFVCNFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILL 2155
TE+E+I A K ANA DF+ P+ + VGERG+Q+SGGQKQRIAIAR LVR P ILL
Sbjct: 4243 SITEEEMIKAAKEANAHDFISKLPEAYDSPVGERGSQMSGGQKQRIAIARALVRRPAILL 4302
Query: 2154 LDEATSALDNESEFIVQEALQKASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHK 1975
LDEATSALD SE VQ AL AS GRTTIVV HRLSTI NA++I+ ++ G++VE G H+
Sbjct: 4303 LDEATSALDLHSEATVQRALDAASKGRTTIVVTHRLSTITNADRIVFIKDGQVVEQGTHE 4362
Query: 1974 QLIAMNGVYNNLVQTQLMSTNYEKMNENEERVTRQSSHSDFPSNEISHQKIDQEDDYV-- 1801
+L+A+ Y LV +T K + + + P + + +
Sbjct: 4363 ELLALGKHYYGLVSADASATARAKATASAAKTVTAAIPKQKPPLKRQFSTLSMHSHRLSL 4422
Query: 1800 ---KKLIAEIKEEGAK--KSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKS 1636
+ A EE K + + I + E+ I L +A+ G +P + L +
Sbjct: 4423 AGASETSANQLEEHEKPYDAPMMRIFGLNKPEWPYNIIGCLAAAMVGASFPAFAVLFGEV 4482
Query: 1635 YEAYAFDKDEMLSKSHFWALSILFL--AFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKH 1462
Y DE + + SILFL + F Q Y FG +++ ++R ++F
Sbjct: 4483 YYVLGLQDDEEVRRETV-NFSILFLVVGVVTGLGTFLQMYMFGLAGVRMTTRIRKITFAA 4541
Query: 1461 LMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSW 1282
++ +YD+ ++ L RL++D+ V A R+G+++ L ++L + +S +Y+W
Sbjct: 4542 MLKQEMGWYDEDTNSVGALCARLSSDAGAVQGATGTRVGAILQALSTLVLGIGLSMYYTW 4601
Query: 1281 KMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENR 1102
KM+L ++ PL+ A + + ++ E + R AIEA+ N+RTV +L E
Sbjct: 4602 KMTLVSVVSIPLVLGAVFFEARVMSGQGLQEKKKMEAATRIAIEAISNIRTVASLGKEEA 4661
Query: 1101 VILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTY 922
+ S L + + R ++G + FF YA+S +G LV E + D
Sbjct: 4662 FLQRYCSELDHVAEATRIRQRLRGLVFSCGQTTPFFGYALSLYYGGALVATEGLNYQDVI 4721
Query: 921 LVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFHLF-TYPAI-MPYDSSQGKRNIK-NG 751
V L + G A+A+ P+ A +AG IF L P I P DS + K +G
Sbjct: 4722 KVSEALIFGSWMLGQALAFAPNFNTAKISAGRIFKLLDRVPEIASPPDSEDKDLDWKADG 4781
Query: 750 EIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGE 571
I+ V F Y R + IL G++L + G+ +ALVG SG GKST I LL+R Y + G
Sbjct: 4782 LIQFSKVEFHYPTRPEMQILQGLNLIVKPGQMVALVGQSGCGKSTCIQLLQRLYDPISGT 4841
Query: 570 VKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQL-EIDQALKVAN 394
V +D ++ V+L +LR + +V QEPVLF+ +I EN +G + + EI +A K +N
Sbjct: 4842 VTMDRRDISSVSLRNLRSQLGVVGQEPVLFDRTIAENIAYGDNFRLVPMDEIIEAAKKSN 4901
Query: 393 AFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKV 214
SFVS P G DT +G +G QLSGGQKQRIAIARA++RNP+VLLLDEATSALD+ SEKV
Sbjct: 4902 IHSFVSSLPLGYDTRLGSKGTQLSGGQKQRIAIARALVRNPRVLLLDEATSALDTQSEKV 4961
Query: 213 VQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQK 34
VQ ALD A E + + +AHRL+T+ NAD I VL+ G VAE GTH++L+ +Y L
Sbjct: 4962 VQAALDKAMEGRTCITIAHRLATIRNADVICVLEKGTVAEMGTHDDLIAADGLYAHLHAL 5021
Query: 33 QGIQVE 16
Q +E
Sbjct: 5022 QEAAME 5027
Score = 323 bits (829), Expect = 2e-86
Identities = 266/950 (28%), Positives = 441/950 (46%), Gaps = 101/950 (10%)
Frame = -1
Query: 2586 LKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDI-----YNINIK 2422
++ +S V+ G+C L+G +G+GKST ++L +GRI + G +I N +
Sbjct: 3446 VQNLSIGVEAGKCFGLLGTNGAGKSTTFRMLTTEIIPTAGRIIVRGKEIGSGPLCNGEVG 3505
Query: 2421 QLRQAMGVV-FQEPVLFNTSIEENIRFGK-PDATEQEI--IDALKNANAFDFVCNFPDGI 2254
Q+ G+ F P T E P A E + +D LK A+
Sbjct: 3506 YCPQSDGIDGFLSPHQCLTIHGEVCGLSNVPKAVESALKRLDLLKYAH------------ 3553
Query: 2253 KTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGR 2074
+R + LSGG K+++ A +++ ++L+DE TS +D ++ +V + ++ + +
Sbjct: 3554 -----KRVSSLSGGNKRKLCTALSVMAPVPVVLMDEPTSGMDPATKDLVTKTIKHLTRNQ 3608
Query: 2073 TTIVV-AHRLSTIRN-ANKIIVMEKGEIVEVGDHKQLIAMNG---VYNNLVQTQLMSTNY 1909
T +++ +H ++ N N++ ++ K + +G + L G V + + +T+
Sbjct: 3609 TCVILTSHSVADCENVCNRVGILAKAGLRCIGTPQHLKHKFGEGYVAFLRFRQPIPATDL 3668
Query: 1908 EKMNEN--EERV--TRQSSHSDFPSNEISHQKIDQEDDYVKKLIAEIK--EEGAKKSNIC 1747
K N + V +RQ S + + + +K L E+K + +S++
Sbjct: 3669 RKAVRNYLPQAVVSSRQGSAARLLIPRSQDMPVSASFNKLKLLADELKATDYTLTQSSLD 3728
Query: 1746 EIIKYCRSEYCILFIAVLGSAIQGIYYPLSS----------------------QLMIK-- 1639
+ E ++F ++ + G+ P+S+ L++K
Sbjct: 3729 QFRFATCGELMLIFGGLIMGTLTGLCIPISTIQYGEFTTLLVDRNMKNHTSTPTLIMKWF 3788
Query: 1638 -------SYEAYAFDKDEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLR 1480
S Y + + S + +S L+ + +F F A + +++R
Sbjct: 3789 GGGKVLGSNSTYKERMEALYDDSVAFGVSSAALSTFQFVFAVFTVDLLNVAASRQIVRVR 3848
Query: 1479 SMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDD------------------ 1354
M + ++ +YD +T+T ++R+ ++ V DD
Sbjct: 3849 KMFLRSVLRQDMTWYD--INTSTNFASRITDGNNLVNNLRDDAVFCHNGDRRGNHGGFDL 3906
Query: 1353 -------------------------RLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCP 1249
+LG +V+ + ++I+SF Y WK++L VL P
Sbjct: 3907 EDECKRDRVDGGAKDLDKMKDGIGEKLGVFTYLMVSFISSIIISFVYGWKLTLVVLSCAP 3966
Query: 1248 LLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQK 1069
++ +A ++ A+ ++ A E L +RTV A N E + + L
Sbjct: 3967 IIVIATAVVAKVQSSLTAQELTAYGQAGSVAEEVLGAIRTVIAFNGEQKEVNRYAEKLIP 4026
Query: 1068 IRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLRE------EILPMDTYLVLMT 907
+ KR + G G + YA++F +G L+L + E P +V
Sbjct: 4027 AEKTGIKRGMWSGVGGGVMWFIIYISYAIAFWYGVQLILEDRPKEVKEYTPAVLVIVFFG 4086
Query: 906 LSMTASYAGSAVAYLPDHRKAIHAAGLIFH-LFTYPAIMPYDSSQGKRNIKNGEIELKNV 730
+ A G +L A +A IF L P I K NGEIE KNV
Sbjct: 4087 VLAGAQNMGLTSPHLEAFAVARGSAAAIFQVLDRVPTIDSLSKEGQKLPAVNGEIEFKNV 4146
Query: 729 SFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEEN 550
F+Y R D +L G++L + G T+ALVG SG GKST + L++R Y G+V +D +
Sbjct: 4147 HFQYPARKDVKVLQGLNLTINRGETVALVGGSGCGKSTCLQLIQRLYDPHKGQVLLDGVD 4206
Query: 549 VVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQF 370
V +N+ LR + +V QEPVLF+ +I+EN +G + + ++ E+ +A K ANA F+S+
Sbjct: 4207 VSKLNVQWLRSHIGVVGQEPVLFDTTIRENIRYG-NDSITEEEMIKAAKEANAHDFISKL 4265
Query: 369 PQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTA 190
P+ D+ VGERG+Q+SGGQKQRIAIARA++R P +LLLDEATSALD SE VQ ALD A
Sbjct: 4266 PEAYDSPVGERGSQMSGGQKQRIAIARALVRRPAILLLDEATSALDLHSEATVQRALDAA 4325
Query: 189 SERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLV 40
S+ +T+VV HRLST+ NAD I +K+G+V EQGTHEELL Y+ LV
Sbjct: 4326 SKGRTTIVVTHRLSTITNADRIVFIKDGQVVEQGTHEELLALGKHYYGLV 4375
Score = 71.2 bits (173), Expect = 2e-10
Identities = 56/233 (24%), Positives = 115/233 (49%), Gaps = 4/233 (1%)
Frame = -1
Query: 2640 ISFKNVLFSYPT-RPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGR 2464
+ F V Y T + ++ + + + + GE +L+G +G+GK+T+I++L +G
Sbjct: 2580 VRFDGVRKVYNTDQGEIVAVDDFTLKLSEGEVTSLLGRNGAGKTTIIKMLTGMLAPTTGE 2639
Query: 2463 ISIDGNDIYNINIKQLRQAMGVVFQEPVLFNTSI--EENIRFGKPDATEQEIIDALKNAN 2290
I ++G + + +GV Q+ VL T E + + K +++E + +N +
Sbjct: 2640 ICLNGEE-------GCKPDIGVCPQDNVLIGTLTPREHLLFYAKLKRSKEEYANVQRNVD 2692
Query: 2289 AFDFVCNFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFI 2110
+ + + G + E +LSGG K+R+ +A + +P++++LDE + +D +
Sbjct: 2693 --EMLTSLELGSQE--HEPVYRLSGGTKRRLCVALAFLGSPKLVILDEPGAGVDPAARRR 2748
Query: 2109 VQEALQKASIGRTTIVVAHRLSTIRN-ANKIIVMEKGEIVEVGDHKQLIAMNG 1954
+ + + GRT I+ H L ++ ++VM KG+I+ G L M+G
Sbjct: 2749 IWRLIDQHRTGRTVILSTHHLDEADTLSDTVVVMHKGKILCTGSPLSLKMMHG 2801
Score = 67.8 bits (164), Expect = 2e-09
Identities = 76/341 (22%), Positives = 141/341 (41%), Gaps = 19/341 (5%)
Frame = -1
Query: 1005 CYFFIYAVSFKFG----TWLVLREEILPMDTY---LVLMTLSMTASYAGSAVAYLPDHRK 847
CY +YA + TW + EE P D+ L+L+T++ + + + YL
Sbjct: 2502 CYGCLYAARKEVQGVGLTWSAMWEESSPGDSMSLGLILLTIAFDG-FLYAVIGYL----- 2555
Query: 846 AIHAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEY--------AQRSDKMIL 691
I Y +S + N + + K + + + + +
Sbjct: 2556 ----------------IARYTNSDEESNATSLTVNEKQTGVRFDGVRKVYNTDQGEIVAV 2599
Query: 690 DGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESV 511
D +LKL G +L+G +G+GK+TII +L GE+ ++ E + +
Sbjct: 2600 DDFTLKLSEGEVTSLLGRNGAGKTTIIKMLTGMLAPTTGEICLNGEE-------GCKPDI 2652
Query: 510 SLVSQEPVLFNC-SIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERG 334
+ Q+ VL + +E+ LF S+ E AN V + L+ E
Sbjct: 2653 GVCPQDNVLIGTLTPREHLLFYAKLKRSKEEY------ANVQRNVDEMLTSLELGSQEHE 2706
Query: 333 A--QLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVA 160
+LSGG K+R+ +A A L +PK+++LDE + +D + + + +D + ++
Sbjct: 2707 PVYRLSGGTKRRLCVALAFLGSPKLVILDEPGAGVDPAARRRIWRLIDQHRTGRTVILST 2766
Query: 159 HRLSTV-VNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLV 40
H L +D++ V+ GK+ G+ L +RL+
Sbjct: 2767 HHLDEADTLSDTVVVMHKGKILCTGSPLSLKMMHGRGYRLL 2807
>gi|50546639|ref|XP_500789.1| hypothetical protein [Yarrowia
lipolytica]
gi|49646655|emb|CAG83040.1| unnamed protein product [Yarrowia
lipolytica CLIB99]
Length = 1304
Score = 640 bits (1650), Expect = 0.0
Identities = 429/1262 (33%), Positives = 664/1262 (51%), Gaps = 36/1262 (2%)
Frame = -1
Query: 3699 TFGFQIKCTTRYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPV 3520
TF + +++ L +G+V + G+C P + G +TN N +
Sbjct: 72 TFMTLFRYADKFDFFLIMVGLVMAAAAGVCLPIFTIIFGS-------MTNEFTNFFVYGA 124
Query: 3519 DLAHAYKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRK 3340
H F+S +N L F + A F ++ I G+ +R Y+ +LR+
Sbjct: 125 SKEH----FQSRINHFALYFVYLAVATFGTTAIKTYITVERGERLTARIRANYLKAILRQ 180
Query: 3339 DISYFDGMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYG 3160
+I YFD + G ++ + + +E +EK+ LI++ + F+ ++ F +L
Sbjct: 181 NIGYFDKLGAGEVTNRITSDTNLIQEGISEKLGLIVSAIASFITALVIGFIKQAKLTGIM 240
Query: 3159 TVFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYT 2980
F + LS + S +K + E S SIA +A + + + Q + VE+Y
Sbjct: 241 LSTVFALALSMGICSTFLVKYTKLALEDDSACSSIAEEAFSSIRNIVAFGSQSRMVEKYN 300
Query: 2979 EELKNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYI 2800
L + L + ++ + + L+ G+ ++ G + G V +L +
Sbjct: 301 VPLASSLHNYLRKNISLAVMVGCLWSLIYIKYALALWEGSRLVAWGETQVGNVTTVLMAL 360
Query: 2799 LFGSYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIKDTFQGIISFKNVL 2620
+ G++ LG ++ + AI I + + E+I D +G I F NV
Sbjct: 361 MIGAFELGGVAPNLESVGVAIASGKKIFGTIDRVPEIDTQEEGEKIPD-IKGHIVFDNVD 419
Query: 2619 FSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDI 2440
F YP+RP V +L++ + V G+ +ALVGASGSGKST+I LL +Y SG I+IDG ++
Sbjct: 420 FRYPSRPKVQILEDFNLEVLPGQTVALVGASGSGKSTLIGLLERFYQPLSGLITIDGYNL 479
Query: 2439 YNINIKQLRQAMGVVFQEPVLFNTSIEENIRFG--------KPDATEQEIID-ALKNANA 2287
++++K LRQ + +V QEP LFN +I ENI FG D + E+++ A + ANA
Sbjct: 480 LDLDVKWLRQHISLVSQEPTLFNCTIYENITFGLIGTQWEHADDEKKMELVEHACRQANA 539
Query: 2286 FDFVCNFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIV 2107
+DF+ DGI T VGE G LSGGQKQRIAIAR ++ NP ILLLDEATSALD +SE IV
Sbjct: 540 WDFIQLLTDGINTNVGESGMLLSGGQKQRIAIARAIISNPPILLLDEATSALDTKSEGIV 599
Query: 2106 QEALQKASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQ 1927
QEAL KAS RTTIV+AHRLSTI+NA+KI+VM KGEI+E G H +L+A G+Y LV Q
Sbjct: 600 QEALDKASENRTTIVIAHRLSTIKNASKIVVMSKGEIIEQGTHAELLAKQGMYYGLVDAQ 659
Query: 1926 LMSTNYEKMNENEERVTRQSSHSDFPSNEISHQKIDQEDDYV-------KKLIAEI---- 1780
K+ E S D P + QEDD K L ++I
Sbjct: 660 -------KLTEARPGQKSSSDGEDAP-------LLIQEDDMKIGKSTTNKSLSSQILANK 705
Query: 1779 -KEEGAKKSNICEII----KYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFD 1615
K + K +I ++ KY R+E L++ + I G YP + L + +A+
Sbjct: 706 EKPDRDKHLSIAGMVKLLAKYNRNERPFLYVGSFAALINGAGYPALALLFASAMQAFMVS 765
Query: 1614 KDE---MLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPC 1444
D M S+ + ++ + + + F Q Y G +E L +R F HL+ +
Sbjct: 766 PDMYHWMRSEMNKYSGFLFMVGMIELMAYFVQIYCLGWCSEHLVRNIRHSVFSHLLRMDV 825
Query: 1443 AFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQV 1264
AF+D+ +T L++ L+ D+ V G ++ +L I++ VI++ Y+W++ L
Sbjct: 826 AFHDEDDNTTGSLTSTLSKDAQYVQGLGGATFGQILSSLCTIVIGVIIAICYTWRLGLVC 885
Query: 1263 LMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVT 1084
PL+ AG+ + +E+S A EA ++RTV L E+ V
Sbjct: 886 TACVPLIIAAGFFRFWILTHLNLRGKKVYEQSASYACEATTSIRTVVTLTREDYV---YN 942
Query: 1083 SHLQKIRNSYFKRA---VIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLV- 916
+L K+ + A + T + S I A+ F +G+ L +++ I+ + + V
Sbjct: 943 DYLHKVESQVADSARANIYSATLFAASQSLNLLISALGFWYGSTL-MKDGIIDTNKFFVA 1001
Query: 915 LMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQG---KRNIKNGEI 745
+++ AGS ++ PD KA A I ++ + DS++G + G+I
Sbjct: 1002 FVSVVFGCQSAGSIFSFTPDMGKAKTATQNIANMLAVLPELDVDSTEGIILDHDNVRGDI 1061
Query: 744 ELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVK 565
++V F Y R IL G++L + G+ +ALVG SG GKST I+L+ERFY + G VK
Sbjct: 1062 SFEDVRFRYPTRPQVPILRGLNLNIKKGQYVALVGSSGCGKSTTIALIERFYDVLSGAVK 1121
Query: 564 IDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFG-ISHNASQLEIDQALKVANAF 388
+D ++ D+N++ R +SLV QEPVLF+ +++EN L G + + ++ E+ +A ++AN
Sbjct: 1122 LDGVDIRDININSYRSCISLVQQEPVLFSGTVRENILLGSLRDDVTEEEMIEAAEMANIH 1181
Query: 387 SFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQ 208
SFV P G DT G +G+ LSGGQKQR+AIARA++RNPK+LLLDEATSALDS+SEK+VQ
Sbjct: 1182 SFVMSLPDGYDTYCGSKGSLLSGGQKQRVAIARALIRNPKILLLDEATSALDSESEKIVQ 1241
Query: 207 NALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQG 28
ALD A++ +T+ VAHRLST+ NAD I V + G+V E GTH+ELL +S Y+ LV+ Q
Sbjct: 1242 AALDQAAKGRTTIAVAHRLSTIQNADIIYVFEEGRVLESGTHQELLANKSKYYELVKLQA 1301
Query: 27 IQ 22
++
Sbjct: 1302 LE 1303
>gi|26449438|dbj|BAC41846.1| putative P-glycoprotein [Arabidopsis
thaliana]
Length = 1252
Score = 640 bits (1650), Expect = 0.0
Identities = 399/1229 (32%), Positives = 649/1229 (52%), Gaps = 16/1229 (1%)
Frame = -1
Query: 3669 RYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFE 3490
+++ LL F+G + +I+ G P G+ + N +D + H
Sbjct: 35 KFDYLLMFVGSLGAIVHGSSMPVFFLLFGQ-------MVNGFGKNQMDLHQMVH------ 81
Query: 3489 SDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFD-GMS 3313
+++R L F +G + + + + G+ +R++Y+ +L++D+ +FD
Sbjct: 82 -EVSRYSLYFVYLGLVVCFSSYAEIACWMYSGERQVAALRKKYLEAVLKQDVGFFDTDAR 140
Query: 3312 TGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVL 3133
TG + ++ + ++ +EK+ I L+ F+ G ++ F + W+LA GI
Sbjct: 141 TGDIVFSVSTDTLLVQDAISEKVGNFIHYLSTFLAGLVVGFVSAWKLALLSVAVIPGIAF 200
Query: 3132 SGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKY 2953
+G L ++ K E +NAG IA QA+ +TV S G+ + + Y++ ++ K
Sbjct: 201 AGGLYAYTLTGITSKSRESYANAGVIAEQAIAQVRTVYSYVGESKALNAYSDAIQYTLKL 260
Query: 2952 ALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGE 2773
L Y ++ ++ I G + G ++ + G LG+
Sbjct: 261 GYKAGMAKGLGLGCTYGIACMSWALVFWYAGVFIRNGQTDGGKAFTAIFSAIVGGMSLGQ 320
Query: 2772 AILHISRLASAIPLTVPIADILLDSDATADEFFSEEIKDTFQGIISFKNVLFSYPTRPDV 2593
+ ++ + + +I+ + + D G I FK+V FSYP+RPDV
Sbjct: 321 SFSNLGAFSKGKAAGYKLMEIINQRPTIIQDPLDGKCLDQVHGNIEFKDVTFSYPSRPDV 380
Query: 2592 PVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLR 2413
+ + + G+ +A+VG SGSGKSTV+ L+ +Y+ +SG+I +DG +I + +K LR
Sbjct: 381 MIFRNFNIFFPSGKTVAVVGGSGSGKSTVVSLIERFYDPNSGQILLDGVEIKTLQLKFLR 440
Query: 2412 QAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGER 2233
+ +G+V QEP LF T+I ENI +GKPDAT E+ A ANA F+ P G T VGER
Sbjct: 441 EQIGLVNQEPALFATTILENILYGKPDATMVEVEAAASAANAHSFITLLPKGYDTQVGER 500
Query: 2232 GAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAH 2053
G QLSGGQKQRIAIAR ++++P+ILLLDEATSALD SE IVQEAL + +GRTT+VVAH
Sbjct: 501 GVQLSGGQKQRIAIARAMLKDPKILLLDEATSALDASSESIVQEALDRVMVGRTTVVVAH 560
Query: 2052 RLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLM--STNYEKMNENEERV 1879
RL TIRN + I V+++G++VE G H++LIA +G Y +L++ Q M + ++ + R
Sbjct: 561 RLCTIRNVDSIAVIQQGQVVETGTHEELIAKSGAYASLIRFQEMVGTRDFSNPSTRRTRS 620
Query: 1878 TRQSSHSDFPS--------NEISHQKIDQEDDYVKKLI-AEI-KEEGAKKSNICEIIKYC 1729
TR S S +S+ D ++ + AE ++ A ++ ++K
Sbjct: 621 TRLSHSLSTKSLSLRSGSLRNLSYSYSTGADGRIEMISNAETDRKTRAPENYFYRLLKLN 680
Query: 1728 RSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAF-DKDEMLSKSHFWALSILFLAFT 1552
E+ + +GS + G P + +M E + + D D M K+ + +
Sbjct: 681 SPEWPYSIMGAVGSILSGFIGPTFAIVMSNMIEVFYYTDYDSMERKTKEYVFIYIGAGLY 740
Query: 1551 RPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNV 1372
Q+YFF E L+ ++R M ++ ++D+ H ++ ++ RL D+++V
Sbjct: 741 AVGAYLIQHYFFSIMGENLTTRVRRMMLSAILRNEVGWFDEDEHNSSLIAARLATDAADV 800
Query: 1371 TAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEE 1192
+A+ +R+ ++ + ++L + I++F W++SL +L PLL LA + + +
Sbjct: 801 KSAIAERISVILQNMTSLLTSFIVAFIVEWRVSLLILGTFPLLVLANFAQQLSLKGFAGD 860
Query: 1191 DSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFA 1012
+ A K++ A E + N+RTV A N +++++ L L+ + R+ G G +
Sbjct: 861 TAKAHAKTSMIAGEGVSNIRTVAAFNAQSKILSLFCHELRVPQKRSLYRSQTSGFLFGLS 920
Query: 1011 CSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAA 832
+ A+ +G LV + V + L +TA+ V+ P+ + A
Sbjct: 921 QLALYGSEALILWYGAHLVSKGVSTFSKVIKVFVVLVITANSVAETVSLAPEIIRGGEAV 980
Query: 831 GLIFH-LFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRT 655
G +F L I P D+ G+IE ++V F Y R D M+ +L++ AG +
Sbjct: 981 GSVFSVLDRQTRIDPDDADADPVETIRGDIEFRHVDFAYPSRPDVMVFRDFNLRIRAGHS 1040
Query: 654 LALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNC 475
ALVG SGSGKS++I+++ERFY + G+V ID +++ +NL LR + LV QEP LF
Sbjct: 1041 QALVGASGSGKSSVIAMIERFYDPLAGKVMIDGKDIRRLNLKSLRLKIGLVQQEPALFAA 1100
Query: 474 SIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAI 295
+I +N +G A++ E+ A + ANA F+S P+G T VGERG QLSGGQKQRIAI
Sbjct: 1101 TIFDNIAYG-KDGATESEVIDAARAANAHGFISGLPEGYKTPVGERGVQLSGGQKQRIAI 1159
Query: 294 ARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVL 115
ARA+L+NP VLLLDEATSALD++SE V+Q AL+ +TVVVAHRLST+ D I V+
Sbjct: 1160 ARAVLKNPTVLLLDEATSALDAESECVLQEALERLMRGRTTVVVAHRLSTIRGVDCIGVI 1219
Query: 114 KNGKVAEQGTHEELL-RKRSIYWRLVQKQ 31
++ ++ EQG+H EL+ R Y RL+Q Q
Sbjct: 1220 QDERIVEQGSHSELVSRPEGAYSRLLQLQ 1248
>gi|27368847|emb|CAD59581.1| MDR-like ABC transporter [Oryza sativa
(japonica cultivar-group)]
Length = 1256
Score = 638 bits (1645), Expect = 0.0
Identities = 393/1169 (33%), Positives = 628/1169 (53%), Gaps = 23/1169 (1%)
Frame = -1
Query: 3468 LLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFD-GMSTGHLSIV 3292
L F +G +L+ + + G+ +RR+Y+ +LR+D+ +FD TG +
Sbjct: 90 LYFVYLGLVVCASSYLEIACWMYTGERQVGALRRRYLEAVLRQDVGFFDTDARTGDVVFS 149
Query: 3291 LNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLLDSW 3112
++ + ++ EK+ I L+ F+ G ++ F + WRLA GI +G L ++
Sbjct: 150 VSTDTLLVQDAIGEKVGNFIHYLSTFLAGLVVGFVSAWRLALLSIAVIPGIAFAGGLYAY 209
Query: 3111 GKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNRAFV 2932
K + +NAG IA QA+ +TV S G+ + + Y+E ++N K
Sbjct: 210 TLTGLTSKSRDSYANAGIIAEQAIAQVRTVYSYVGESKALNSYSEAIQNTLKLGYKAGMA 269
Query: 2931 FSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEAILHISR 2752
L Y ++ ++ I G + G ++ + G LG++ ++
Sbjct: 270 KGLGIGCTYGIACMSWALVFWYAGVFIRNGQTDGGKAFTAIFSAIVGGLSLGQSFSNLGA 329
Query: 2751 LASAIPLTVPIADILLDSDATADEFFSEEIKDTFQGIISFKNVLFSYPTRPDVPVLKEIS 2572
+ + +++ + D G I FK V FSYP+RPDV + ++ S
Sbjct: 330 FSKGKIAGYKLLEVIRQRPTIVQDPADGRCLDEVHGNIEFKEVAFSYPSRPDVMIFRDFS 389
Query: 2571 FNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAMGVVF 2392
G+ A+VG SGSGKSTV+ L+ +Y+ + G++ +D DI + +K LR +G+V
Sbjct: 390 LFFPAGKTAAVVGGSGSGKSTVVALIERFYDPNQGQVLLDNVDIKTLQLKWLRDQIGLVN 449
Query: 2391 QEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGERGAQLSGG 2212
QEP LF T+I ENI +GKPDAT E+ A +ANA F+ P+G T VGERG QLSGG
Sbjct: 450 QEPALFATTILENILYGKPDATMAEVEAAATSANAHSFIALLPNGYNTQVGERGLQLSGG 509
Query: 2211 QKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHRLSTIRN 2032
QKQRIAIAR +++NP+ILLLDEATSALD SE IVQEAL + +GRTT+VVAHRLSTIR
Sbjct: 510 QKQRIAIARAMLKNPKILLLDEATSALDAGSENIVQEALDRLMVGRTTVVVAHRLSTIRC 569
Query: 2031 ANKIIVMEKGEIVEVGDHKQLIA--MNGVYNNLVQTQLMSTNYEKMNENEERVTRQSSHS 1858
+ I V+++G++VE G H +L+A +G Y L++ Q M+ N + + TR+S S
Sbjct: 570 VDMIAVIQQGQVVETGTHDELLAKGSSGAYAALIRFQEMARNRDFRGPS----TRKSRSS 625
Query: 1857 DFPSNEISHQKIDQEDDYVKKLIAEI-----------------KEEGAKKSNICEIIKYC 1729
SN +S + + ++ L ++ A K +++K
Sbjct: 626 RL-SNSLSTRSLSLRSGSLRNLSYSYSTGADGRIEMVSNADNDRKYPAPKGYFFKLLKLN 684
Query: 1728 RSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAF-DKDEMLSKSHFWALSILFLAFT 1552
E+ + +GS + G P + +M E + F D + M K+ + +
Sbjct: 685 APEWPYTILGAIGSILSGFIGPTFAIVMSNMIEVFYFRDPNAMERKTREYVFIYIGTGLY 744
Query: 1551 RPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNV 1372
+ Q+YFF E L+ ++R M ++ ++D + ++ ++ RL+ D+++V
Sbjct: 745 AVVAYLVQHYFFSIMGENLTTRVRRMMLAAILRNDVGWFDQEENNSSLVAARLSTDAADV 804
Query: 1371 TAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEE 1192
+A+ +R+ ++ + ++L++ ++ F W++++ +L+ PLL LA + + +
Sbjct: 805 KSAIAERISVILQNMTSLLVSFVVGFIIEWRVAVLILVTFPLLVLANFAQQLSMKGFAGD 864
Query: 1191 DSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFA 1012
+ A K++ A E + N+RTV A N +++V+ L + L+ + +R+ I G G +
Sbjct: 865 TAKAHAKTSMIAGEGVSNIRTVAAFNAQDKVLSLFCTELRVPQMHSLRRSQISGALFGLS 924
Query: 1011 CSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAA 832
+ A+ +G LV V + L +TA+ V+ P+ + +
Sbjct: 925 QLSLYASEALILWYGAHLVRHHVSTFSKVIKVFVVLVITANTVAETVSLAPEIVRGGESI 984
Query: 831 GLIFHLFTY-PAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRT 655
+F + Y I P + G+I+ ++V F Y R D M+ SL++ AG++
Sbjct: 985 RSVFAILNYRTRIDPDEPETEPVESVRGDIDFRHVDFAYPSRPDVMVFKDFSLRIRAGQS 1044
Query: 654 LALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNC 475
ALVG SGSGKST+I+L+ERFY + G+V ID +++ +N+ LR + LV QEPVLF
Sbjct: 1045 QALVGASGSGKSTVIALIERFYDPLAGKVMIDGKDIRRLNVRSLRLKIGLVQQEPVLFAT 1104
Query: 474 SIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAI 295
SI EN +G A++ E+ +A KVAN FVS P+G T VGERG QLSGGQKQRIAI
Sbjct: 1105 SIFENIAYG-KDGATEEEVIEAAKVANMHGFVSALPEGYKTPVGERGVQLSGGQKQRIAI 1163
Query: 294 ARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVL 115
ARA+L++P VLLLDEATSALD++SE V+Q AL+ + + V+VAHRLST+ DSIAV+
Sbjct: 1164 ARAVLKDPAVLLLDEATSALDAESECVLQEALERIMKGRTAVLVAHRLSTIRGVDSIAVV 1223
Query: 114 KNGKVAEQGTHEELL-RKRSIYWRLVQKQ 31
++G+V EQG+H EL+ R Y RL+Q Q
Sbjct: 1224 QDGRVVEQGSHGELVSRPDGAYSRLLQLQ 1252
Score = 312 bits (799), Expect = 5e-83
Identities = 209/586 (35%), Positives = 328/586 (55%), Gaps = 12/586 (2%)
Frame = -1
Query: 3645 LGVVFSILTGMCQPFESYTLGETSQVLV-KVTNAINNKTIDPVDLAHAYKLFESDMNRVV 3469
LG + SIL+G P + + +V + NA+ KT + V + L+
Sbjct: 693 LGAIGSILSGFIGPTFAIVMSNMIEVFYFRDPNAMERKTREYVFIYIGTGLY-------A 745
Query: 3468 LLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMSTGHLSIV- 3292
++ +LV YF FSIM G+N VRR ++ +LR D+ +FD + S+V
Sbjct: 746 VVAYLVQH-YF------FSIM---GENLTTRVRRMMLAAILRNDVGWFD-QEENNSSLVA 794
Query: 3291 --LNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLLD 3118
L+ + + E+I++I+ +T ++ ++ F +WR+A V +VL+
Sbjct: 795 ARLSTDAADVKSAIAERISVILQNMTSLLVSFVVGFIIEWRVAVLILVTFPLLVLANFAQ 854
Query: 3117 SWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNRA 2938
+ + IA + + +TV++ N Q + + + EL+ + ++L R+
Sbjct: 855 QLSMKGFAGDTAKAHAKTSMIAGEGVSNIRTVAAFNAQDKVLSLFCTELRVPQMHSLRRS 914
Query: 2937 FV----FSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEA 2770
+ F LS+ + Y A +IL++GA+++ V+++ ++ + + E
Sbjct: 915 QISGALFGLSQLSLY----ASEALILWYGAHLVRHHVSTFSKVIKVFVVLVITANTVAET 970
Query: 2769 IL---HISRLASAIPLTVPIADILLDSDATADEFFSEEIKDTFQGIISFKNVLFSYPTRP 2599
+ I R +I I + D E E ++ +G I F++V F+YP+RP
Sbjct: 971 VSLAPEIVRGGESIRSVFAILNYRTRIDPDEPE---TEPVESVRGDIDFRHVDFAYPSRP 1027
Query: 2598 DVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQ 2419
DV V K+ S ++ G+ ALVGASGSGKSTVI L+ +Y+ +G++ IDG DI +N++
Sbjct: 1028 DVMVFKDFSLRIRAGQSQALVGASGSGKSTVIALIERFYDPLAGKVMIDGKDIRRLNVRS 1087
Query: 2418 LRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVG 2239
LR +G+V QEPVLF TSI ENI +GK ATE+E+I+A K AN FV P+G KT VG
Sbjct: 1088 LRLKIGLVQQEPVLFATSIFENIAYGKDGATEEEVIEAAKVANMHGFVSALPEGYKTPVG 1147
Query: 2238 ERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVV 2059
ERG QLSGGQKQRIAIAR ++++P +LLLDEATSALD ESE ++QEAL++ GRT ++V
Sbjct: 1148 ERGVQLSGGQKQRIAIARAVLKDPAVLLLDEATSALDAESECVLQEALERIMKGRTAVLV 1207
Query: 2058 AHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAM-NGVYNNLVQTQL 1924
AHRLSTIR + I V++ G +VE G H +L++ +G Y+ L+Q QL
Sbjct: 1208 AHRLSTIRGVDSIAVVQDGRVVEQGSHGELVSRPDGAYSRLLQLQL 1253
>gi|15236067|ref|NP_194326.1| multidrug resistance P-glycoprotein,
putative [Arabidopsis thaliana]
gi|7442648|pir||T04251 P-glycoprotein 2 - Arabidopsis thaliana
gi|2108252|emb|CAA71277.1| P-glycoprotein-2 [Arabidopsis thaliana]
gi|2108254|emb|CAA71276.1| P-glycoprotein-2 [Arabidopsis thaliana]
gi|4538925|emb|CAB39661.1| P-glycoprotein-2 (pgp2) [Arabidopsis
thaliana]
gi|7269447|emb|CAB79451.1| P-glycoprotein-2 (pgp2) [Arabidopsis
thaliana]
Length = 1233
Score = 637 bits (1644), Expect = 0.0
Identities = 416/1223 (34%), Positives = 665/1223 (54%), Gaps = 11/1223 (0%)
Frame = -1
Query: 3666 YEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFES 3487
Y+ +L LG V + + G P G K+ N I + P +H +
Sbjct: 32 YDCVLMTLGSVGACIHGASVPIFFIFFG-------KLINIIGLAYLFPKQASHRVAKYSL 84
Query: 3486 DMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDG-MST 3310
D F + A +L+ + G+ A +RR Y+ +L +DIS FD ST
Sbjct: 85 D-------FVYLSVAILFSSWLEVACWMHTGERQAAKMRRAYLRSMLSQDISLFDTEAST 137
Query: 3309 GHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLS 3130
G + + ++ ++ +EK+ + ++ F+ G + F + W+++ I L+
Sbjct: 138 GEVISAITSDILVVQDALSEKVGNFLHYISRFIAGFAIGFTSVWQISLVTLSIVPLIALA 197
Query: 3129 GLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYA 2950
G + ++ + + + AG IA + +G +TV + G+++ V Y E L+N KY
Sbjct: 198 GGIYAFVAIGLIARVRKSYIKAGEIAEEVIGNVRTVQAFTGEERAVRLYREALENTYKYG 257
Query: 2949 LNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEA 2770
L + + ++++F + ++++ + G + ++ LG+A
Sbjct: 258 RKAGLTKGLGLGSMHCVLFLSWALLVWFTSVVVHKDIADGGKSFTTMLNVVIAGLSLGQA 317
Query: 2769 ILHISRLASAIPLTVPIADILLDSDATADEFFSEEIKDTFQGIISFKNVLFSYPTRPDVP 2590
IS A PI ++ + T S G I FK+ FSYP+RPDV
Sbjct: 318 APDISAFVRAKAAAYPIFKMIERNTVTKTSAKSGRKLGKVDGHIQFKDATFSYPSRPDVV 377
Query: 2589 VLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQ 2410
+ ++ + G+ +ALVG SGSGKSTVI L+ +Y SG + +DGN+I ++IK LR
Sbjct: 378 IFDRLNLAIPAGKIVALVGGSGSGKSTVISLIERFYEPISGAVLLDGNNISELDIKWLRG 437
Query: 2409 AMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGERG 2230
+G+V QEP LF T+I ENI +GK DAT +EI A K + A F+ N P+G +T VGERG
Sbjct: 438 QIGLVNQEPALFATTIRENILYGKDDATAEEITRAAKLSEAISFINNLPEGFETQVGERG 497
Query: 2229 AQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHR 2050
QLSGGQKQRIAI+R +V+NP ILLLDEATSALD ESE VQEAL + +GRTT+VVAHR
Sbjct: 498 IQLSGGQKQRIAISRAIVKNPSILLLDEATSALDAESEKSVQEALDRVMVGRTTVVVAHR 557
Query: 2049 LSTIRNANKIIVMEKGEIVEVGDHKQLIA-MNGVYNNLVQTQLMSTNYEKMNENEERVTR 1873
LST+RNA+ I V+ +G+IVE G+H+ LI+ +G Y++L++ Q ++ + N T
Sbjct: 558 LSTVRNADIIAVVHEGKIVEFGNHENLISNPDGAYSSLLRLQETASLQRNPSLNR---TL 614
Query: 1872 QSSHSDFPSNEISHQKIDQEDDYVKKLIAEIKEEGAK-----KSNICEIIKYCRSEYCIL 1708
HS S E+S + + + + + +GA K + + R ++
Sbjct: 615 SRPHSIKYSRELSRTR----SSFCSERESVTRPDGADPSKKVKVTVGRLYSMIRPDWMYG 670
Query: 1707 FIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDEMLSKSHFWALSILFLAFTRPIFIFF- 1531
+ + I G PL + + ++ +Y DE ++ ++ILF + I +
Sbjct: 671 VCGTICAFIAGSQMPLFALGVSQALVSYYSGWDE--TQKEIKKIAILFCCASVITLIVYT 728
Query: 1530 -QYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDD 1354
++ FG E+L++++R F+ ++ ++D+ +T++ L++RL +D++ + V D
Sbjct: 729 IEHICFGTMGERLTLRVRENMFRAILKNEIGWFDEVDNTSSMLASRLESDATLLKTIVVD 788
Query: 1353 RLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEED-SIAF 1177
R ++ L ++ + I++F +W+++L VL PL+ ++G+ ++ Q D + A+
Sbjct: 789 RSTILLQNLGLVVTSFIIAFILNWRLTLVVLATYPLV-ISGHISEKLFMQGYGGDLNKAY 847
Query: 1176 EKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYF 997
K+N A E++ N+RTV A E +++ L + L + S F+R I G G + F
Sbjct: 848 LKANMLAGESVSNIRTVAAFCAEEKILELYSRELLEPSKSSFRRGQIAGLFYGVSQFFIF 907
Query: 996 FIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFH 817
Y ++ +G+ L+ + M L +TA G +A PD K +F
Sbjct: 908 SSYGLALWYGSTLMDKGLAGFKSVMKTFMVLIVTALAMGETLALAPDLLKGNQMVASVFE 967
Query: 816 LFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGP 637
+ + ++S+ N++ G IELK V F Y R D +I L + AG+++ALVG
Sbjct: 968 ILDRKTQIVGETSEELNNVE-GTIELKGVHFSYPSRPDVVIFRDFDLIVRAGKSMALVGQ 1026
Query: 636 SGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENF 457
SGSGKS++ISL+ RFY G+V I+ +++ ++L LR+ + LV QEP LF +I EN
Sbjct: 1027 SGSGKSSVISLILRFYDPTAGKVMIEGKDIKKLDLKALRKHIGLVQQEPALFATTIYENI 1086
Query: 456 LFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILR 277
L+G + ASQ E+ ++ +ANA SF++ P+G T VGERG Q+SGGQ+QRIAIARAIL+
Sbjct: 1087 LYG-NEGASQSEVVESAMLANAHSFITSLPEGYSTKVGERGVQMSGGQRQRIAIARAILK 1145
Query: 276 NPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVA 97
NP +LLLDEATSALD +SE+VVQ ALD +TVVVAHRLST+ NAD+I+VL GK+
Sbjct: 1146 NPAILLLDEATSALDVESERVVQQALDRLMANRTTVVVAHRLSTIKNADTISVLHGGKIV 1205
Query: 96 EQGTHEEL-LRKRSIYWRLVQKQ 31
EQG+H +L L K Y++L+ Q
Sbjct: 1206 EQGSHRKLVLNKSGPYFKLISLQ 1228
>gi|15229473|ref|NP_189475.1| ABC transporter family protein
[Arabidopsis thaliana]
Length = 1240
Score = 637 bits (1644), Expect = 0.0
Identities = 414/1172 (35%), Positives = 644/1172 (54%), Gaps = 22/1172 (1%)
Frame = -1
Query: 3480 NRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMSTGHL 3301
N V LL+ G + FL+ G+ +R +Y+ +LR+D+ YFD T
Sbjct: 80 NSVALLYVACGS--WVVCFLEGYCWTRTGERQTARMREKYLRAVLRQDVGYFDLHVTSTS 137
Query: 3300 SIVLNDNMERF--REVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSG 3127
++ + + + F ++V +EK+ + + FV I+ F WRLA G F +V+ G
Sbjct: 138 DVITSVSSDSFVIQDVLSEKLPNFLMSASTFVGSYIVGFILLWRLAIVGLPFIVLLVIPG 197
Query: 3126 LLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYAL 2947
L+ + + K E + AG +A QA+ +TV + +G+++ + +++ L+ K +
Sbjct: 198 LMYGRALISISRKIREEYNEAGFVAEQAISSVRTVYAFSGERKTISKFSTALQGSVKLGI 257
Query: 2946 NRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEAI 2767
+ ++ ++ T A+ + ++G+ M+ + G V + I G LG +
Sbjct: 258 KQGLAKGITIGSNGI-TFAMWGFMSWYGSRMVMYHGAQGGTVFAVAAAIAIGGVSLGGGL 316
Query: 2766 LHISRLASAIPLTVPIADIL-----LDSDATADEFFSEEIKDTFQGIISFKNVLFSYPTR 2602
++ A + I +++ +DSD D E+I+ G + FKNV F YP+R
Sbjct: 317 SNLKYFFEAASVGERIMEVINRVPKIDSD-NPDGHKLEKIR----GEVEFKNVKFVYPSR 371
Query: 2601 PDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIK 2422
+ + + V G+ +ALVG SGSGKSTVI LL +Y+ +G I IDG I + +K
Sbjct: 372 LETSIFDDFCLRVPSGKTVALVGGSGSGKSTVISLLQRFYDPLAGEILIDGVSIDKLQVK 431
Query: 2421 QLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIV 2242
LR MG+V QEP LF T+I+ENI FGK DA+ ++++A K +NA +F+ P+G +T V
Sbjct: 432 WLRSQMGLVSQEPALFATTIKENILFGKEDASMDDVVEAAKASNAHNFISQLPNGYETQV 491
Query: 2241 GERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIV 2062
GERG Q+SGGQKQRIAIAR ++++P ILLLDEATSALD+ESE +VQEAL+ ASIGRTTI+
Sbjct: 492 GERGVQMSGGQKQRIAIARAIIKSPTILLLDEATSALDSESERVVQEALENASIGRTTIL 551
Query: 2061 VAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIA-MNGVYNNLVQTQLMSTNYEKMN---- 1897
+AHRLSTIRNA+ I V++ G IVE G H +L+ ++G Y+ LV Q + ++
Sbjct: 552 IAHRLSTIRNADVISVVKNGHIVETGSHDELMENIDGQYSTLVHLQQIEKQDINVSVKIG 611
Query: 1896 --ENEERVTRQSSHSDFPSNEISHQKIDQEDDYVKKLIAEIKEE--GAKKSNICEIIKYC 1729
+ + R SS S S + +K L + K + K+ + ++
Sbjct: 612 PISDPSKDIRNSSRVSTLSRSSSANSVTGPST-IKNLSEDNKPQLPSFKRLLAMNLPEWK 670
Query: 1728 RSEY-CILFIAVLGSAIQGIY-YPLSSQLMIKSYEAYAFDKDEMLSKSHFWALSILFLAF 1555
++ Y CI A L AIQ Y Y L S M+ Y + DE+ K+ +ALS + LA
Sbjct: 671 QALYGCI--SATLFGAIQPAYAYSLGS--MVSVY--FLTSHDEIKEKTRIYALSFVGLAV 724
Query: 1554 TRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSN 1375
+ Q+Y F E L+ ++R +++ ++D +++ + +RL D++
Sbjct: 725 LSFLINISQHYNFAYMGEYLTKRIRERMLSKVLTFEVGWFDRDENSSGAICSRLAKDANV 784
Query: 1374 VTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVE 1195
V + V DR+ V+ T+ A+ +A M +W+++L ++ P++ + Y + +
Sbjct: 785 VRSLVGDRMALVVQTVSAVTIAFTMGLVIAWRLALVMIAVQPVIIVCFYTRRVLLKSMSK 844
Query: 1194 EDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGF 1015
+ A ++S++ A EA+ NVRT+ A + + R++ ++ + R +++ G
Sbjct: 845 KAIKAQDESSKLAAEAVSNVRTITAFSSQERIMKMLEKAQESPRRESIRQSWFAGFGLAM 904
Query: 1014 ACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHA 835
+ S +A+ F +G L+ I + M L T A + D K A
Sbjct: 905 SQSLTSCTWALDFWYGGRLIQDGYITAKALFETFMILVSTGRVIADAGSMTTDLAKGSDA 964
Query: 834 AGLIFH-LFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGR 658
G +F L Y +I P D + G++E +V F Y R D +I S+K+ G+
Sbjct: 965 VGSVFAVLDRYTSIDPEDPDGYETERITGQVEFLDVDFSYPTRPDVIIFKNFSIKIEEGK 1024
Query: 657 TLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFN 478
+ A+VGPSGSGKSTII L+ERFY + G VKID ++ +L LR ++LVSQEP LF
Sbjct: 1025 STAIVGPSGSGKSTIIGLIERFYDPLKGIVKIDGRDIRSYHLRSLRRHIALVSQEPTLFA 1084
Query: 477 CSIKENFLF-GISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRI 301
+I+EN ++ G+S + EI +A K ANA F++ +G DT G+RG QLSGGQKQRI
Sbjct: 1085 GTIRENIIYGGVSDKIDEAEIIEAAKAANAHDFITSLTEGYDTYCGDRGVQLSGGQKQRI 1144
Query: 300 AIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIA 121
AIARA+L+NP VLLLDEATSALDS SE+VVQ+AL+ ++VV+AHRLST+ N D+IA
Sbjct: 1145 AIARAVLKNPSVLLLDEATSALDSQSERVVQDALERVMVGRTSVVIAHRLSTIQNCDAIA 1204
Query: 120 VLKNGKVAEQGTHEELLRK--RSIYWRLVQKQ 31
VL GK+ E+GTH LL K IY+ LV Q
Sbjct: 1205 VLDKGKLVERGTHSSLLSKGPTGIYFSLVSLQ 1236
>gi|5733124|gb|AAD49436.1| P-glycoprotein [Onchocerca volvulus]
Length = 1278
Score = 637 bits (1643), Expect = 0.0
Identities = 434/1292 (33%), Positives = 686/1292 (52%), Gaps = 47/1292 (3%)
Frame = -1
Query: 3759 SNVCKFIKVIVGSTNNFLKKTFG------FQI-KCTTRYEKLLFFLGVVFSILTGMCQPF 3601
S + KFI +I+ +F K+ FQ+ + T ++ + + + +I TG+ QP
Sbjct: 21 SAIDKFISIIL-CRGDFAKQKLDAKPVSFFQLFRFATTCDRFMLSISALLAIFTGIGQPM 79
Query: 3600 ESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFESDMNRVVLLFFLVGFAYFTFGFL 3421
G+ + V + N T F V L+ +G +
Sbjct: 80 ICLIGGKLTNVFLLTKTFERNDT------------FWYQAYIYVYLYASIGITMVITTTI 127
Query: 3420 QFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMSTGHLSIVLNDNMERFREVFNEKIA 3241
Q+ K N +R++Y+ LLR++ ++FD TG L+ LN N+E+ ++ +K+
Sbjct: 128 QYICAKNASLNITCTMRQEYMKSLLRQEAAWFDQQKTGTLTAQLNANIEKIKDGIGDKVG 187
Query: 3240 LIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLLDSWGKMKNNEK--QNEHISN 3067
+I+ +T F+ I+ F DWRL +F G + + LL + + + Q+
Sbjct: 188 MILRGVTMFLTCVIIGFIYDWRLTL--VMFGTGPISAALLSTMARQMEHSSSMQSNTDGR 245
Query: 3066 AGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNRAFVFSLSRSADYFFTNAL 2887
A ++ +++ KTV++ N Q+ ++RY LK K+AL+ A+ F+ F + L
Sbjct: 246 AAAVLEESIMNVKTVAACNAQETMIKRYAATLKACRKFALH-AYAFA-------GFFDGL 297
Query: 2886 NFVILY--FGANMIYEGTI-------EPGVVVRILYYILFGSYCLGEAILHI-----SRL 2749
F++LY F A Y + PG + + I+FGSY LG H+ +R+
Sbjct: 298 FFLVLYVFFAAGFYYGAYLYQIRIIMNPGYIFAVANLIMFGSYNLGVLSPHLMAVLNARV 357
Query: 2748 ASAIPLTVPIADILLDSDATADEFFSEEIKDTFQGIISFKNVLFSYPTRPDVPVLKEISF 2569
A+A+ + DS +T D E+K G I F+NV FSYP + VL +S+
Sbjct: 358 AAAVIYKIINRKPSFDSSST-DGMKVNEVK----GEIEFQNVKFSYPKSKEHLVLNGLSW 412
Query: 2568 NVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAMGVVFQ 2389
+ G+ +ALVG SG GKST LL YN +SG I IDG +I +INI LR +GVV Q
Sbjct: 413 TAKPGDTVALVGHSGCGKSTSTGLLTRLYNCNSGAILIDGINICDINIHTLRNIVGVVQQ 472
Query: 2388 EPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGERGAQLSGGQ 2209
EP+LF+ +I+ENIR GK D T+QEIIDA K ANA DF+ +G T++G G QLSGGQ
Sbjct: 473 EPLLFSGTIKENIRLGKLDLTDQEIIDACKIANAHDFINKLSEGYDTMIGAGGIQLSGGQ 532
Query: 2208 KQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHRLSTIRNA 2029
KQRIAIART+VRNPRILLLDEATSALD ESE IVQ AL+KA +GRTTI++AHRLST+R++
Sbjct: 533 KQRIAIARTIVRNPRILLLDEATSALDAESEVIVQNALKKAFVGRTTIIIAHRLSTLRDS 592
Query: 2028 NKIIVMEKGEIVEVGDHKQLI-AMNGVYNNLVQTQLMSTN------------YEKMNENE 1888
N+IIV++KG++ E+G HK+L +G+Y +LV++Q E + +
Sbjct: 593 NQIIVLDKGQVAEIGTHKELCNNKDGIYASLVKSQQFEAQQKPTSPPVEELPLETFHRSN 652
Query: 1887 ERVTRQSS----HSDFPSNEISHQKIDQEDDYVKKLIAEIKEEGAKKS---NICEIIKYC 1729
R +R SS S F I + K ++ G KKS + ++ C
Sbjct: 653 TRDSRNSSGYGIMSSFTRGSIMSGNVTCVSIPEKSTEITVELNGKKKSKPKGLWQLYTNC 712
Query: 1728 RSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDK-DEMLSKSHFWALSILFLAFT 1552
Y + IA+L S ++G+ PL + ++ +A K + +L + A+ + L
Sbjct: 713 HGNYGKMIIALLVSFLRGLELPLFVLIFDLTFVVFAQAKLESVLERILPIAIIYIALGIA 772
Query: 1551 RPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNV 1372
I IF + FG TAE + LR + ++++ ++D P + R++ D+ +
Sbjct: 773 CLIVIFSATFTFGWTAECVVDSLRLRAMRNMLYQNAEYFDTPSTSTAVTVTRISVDAQTL 832
Query: 1371 ---TAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQA 1201
+A D +++ LV + +AVI ++W + L + + P+ + D +
Sbjct: 833 KRSRSANDANFDNIVAILVLVTIAVI----FNWPVGL-LAVKSPVTHFDADI-DRKYNAE 886
Query: 1200 VEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTAN 1021
V + ++ + + A+E +E +RT++ + E L ++ + K + +
Sbjct: 887 VNKCALKQIVTGQLALEIVEQIRTIQLITGEEHFHRLYVQTIEDLLYLQKKSSPYEAILF 946
Query: 1020 GFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAI 841
S FF +S+ G L+ LP + + +++ + L A
Sbjct: 947 AVTSSFMFFSDMISYAAGIALIYYGYSLPQEIFTASWSIATSGWALIMVSGCLNTFVMAS 1006
Query: 840 HAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAG 661
A+ +F + + M G R G+++ + F Y R + +L+G++L AG
Sbjct: 1007 PASNSLFRIINTGSDM-NSVDDGLRPAITGDVQFNKIKFSYPTRPQRNVLNGLNLAAYAG 1065
Query: 660 RTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLF 481
+T+A+ GPSGSGKST+I+LLERFY G++ +D+ ++ ++L +LRE ++LV QEP+LF
Sbjct: 1066 QTVAVTGPSGSGKSTVIALLERFYRFNSGQLTLDDNSITKISLRYLREQIALVGQEPILF 1125
Query: 480 NCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRI 301
+ +I EN L G + + ++ +A K+AN F+ P+G DT VGE G QLSGGQKQRI
Sbjct: 1126 SGTILENILLGTT-GKTLSDVREACKIANIIDFIETSPKGYDTEVGEHGVQLSGGQKQRI 1184
Query: 300 AIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIA 121
AIARA++RNPK+LLLDEATSALD++ E+ VQ ALD AS + + VAHRLS++ +AD I
Sbjct: 1185 AIARALVRNPKILLLDEATSALDAECERTVQQALDAASSGRTCITVAHRLSSIQHADQIF 1244
Query: 120 VLKNGKVAEQGTHEELLRKRSIYWRLVQKQGI 25
++NGKV E+GTH+EL+ Y L++KQ +
Sbjct: 1245 FVENGKVVEEGTHQELVEFDGKYADLIRKQDL 1276
Score = 249 bits (637), Expect = 3e-64
Identities = 173/534 (32%), Positives = 279/534 (51%), Gaps = 14/534 (2%)
Frame = -1
Query: 3474 VVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMSTGHLSI 3295
+ +++ +G A F + + ++R + + +L ++ YFD ST
Sbjct: 762 IAIIYIALGIACLIVIFSATFTFGWTAECVVDSLRLRAMRNMLYQNAEYFDTPSTSTAVT 821
Query: 3294 VLN-----DNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLS 3130
V ++R R + I+A+L I I + LA V F
Sbjct: 822 VTRISVDAQTLKRSRSANDANFDNIVAILVLVTIAVIFNWPVGL-LAVKSPVTHF----- 875
Query: 3129 GLLDSWGKMKNNEKQNEHISN---AGSIAFQALGCYKTVSSLNGQQQEVERYTEELKN-- 2965
D+ K N + N+ G +A + + +T+ + G++ Y + +++
Sbjct: 876 ---DADIDRKYNAEVNKCALKQIVTGQLALEIVEQIRTIQLITGEEHFHRLYVQTIEDLL 932
Query: 2964 --GEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILFG 2791
+K + A +F+++ S+ FF++ +++ G +IY G P + + I
Sbjct: 933 YLQKKSSPYEAILFAVT-SSFMFFSDMISYAA---GIALIYYGYSLPQEIFTASWSIATS 988
Query: 2790 SYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEE--IKDTFQGIISFKNVLF 2617
G A++ +S + + P ++ L T + S + ++ G + F + F
Sbjct: 989 ----GWALIMVSGCLNTFVMASPASNSLFRIINTGSDMNSVDDGLRPAITGDVQFNKIKF 1044
Query: 2616 SYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIY 2437
SYPTRP VL ++ G+ +A+ G SGSGKSTVI LL +Y +SG++++D N I
Sbjct: 1045 SYPTRPQRNVLNGLNLAAYAGQTVAVTGPSGSGKSTVIALLERFYRFNSGQLTLDDNSIT 1104
Query: 2436 NINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDG 2257
I+++ LR+ + +V QEP+LF+ +I ENI G T ++ +A K AN DF+ P G
Sbjct: 1105 KISLRYLREQIALVGQEPILFSGTILENILLGTTGKTLSDVREACKIANIIDFIETSPKG 1164
Query: 2256 IKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIG 2077
T VGE G QLSGGQKQRIAIAR LVRNP+ILLLDEATSALD E E VQ+AL AS G
Sbjct: 1165 YDTEVGEHGVQLSGGQKQRIAIARALVRNPKILLLDEATSALDAECERTVQQALDAASSG 1224
Query: 2076 RTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMST 1915
RT I VAHRLS+I++A++I +E G++VE G H++L+ +G Y +L++ Q +S+
Sbjct: 1225 RTCITVAHRLSSIQHADQIFFVENGKVVEEGTHQELVEFDGKYADLIRKQDLSS 1278
>gi|34894326|ref|NP_908488.1| unnamed protein product [Oryza sativa
(japonica cultivar-group)]
gi|8468012|dbj|BAA96612.1| unnamed protein product [Oryza sativa
(japonica cultivar-group)]
gi|27368863|emb|CAD59589.1| MDR-like ABC transporter [Oryza sativa
(japonica cultivar-group)]
Length = 1285
Score = 637 bits (1642), Expect = 0.0
Identities = 417/1247 (33%), Positives = 658/1247 (52%), Gaps = 26/1247 (2%)
Frame = -1
Query: 3702 KTFGFQIKCTTRYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDP 3523
K F F K + L LG + ++ G PF + G ID
Sbjct: 58 KLFAFADKT----DAALMALGTLGAVANGAALPFMTVLFGNL---------------IDA 98
Query: 3522 VDLAHAYKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLR 3343
A + ++ V L F + A F+Q + G+ A +R Y+ +LR
Sbjct: 99 FGGAMGIHDVVNRVSMVSLEFIYLAIASAVASFVQVTCWMITGERQAARIRNLYLKTILR 158
Query: 3342 KDISYFDGMS-TGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLAC 3166
++I++FD + TG + ++ + ++ EK+ I L+ F+ G I+AF W L
Sbjct: 159 QEIAFFDKYTNTGEVVGRMSGDTVLIQDAMGEKVGKFIQLVVTFLGGFIVAFAQGWLLTL 218
Query: 3165 YGTVFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVER 2986
+V++G + S K + + + Q +G +TV+S G++Q VE+
Sbjct: 219 VMMATIPPLVVAGAVMSNVVAKMASLGQAAYAESSVVVEQTIGSIRTVASFTGEKQAVEK 278
Query: 2985 YTEELKNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILY 2806
Y + LK+ K + L + +++GA +I V+ +++
Sbjct: 279 YNKSLKSAYKSGVREGLAAGLGMGTVMVLLFCGYSLGIWYGAKLILLKGYTGAKVMNVIF 338
Query: 2805 YILFGSYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIK-DTFQGIISFK 2629
+L GS LG+A + A + + + + D + + +K D +G I F+
Sbjct: 339 AVLTGSLALGQASPSMKAFAGGQAAAYKMFETI-NRKPEIDAYSTTGMKPDDIRGDIEFR 397
Query: 2628 NVLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDG 2449
+V FSYPTRPD + + S ++ G +ALVG SGSGKSTVI L+ +Y+ G + IDG
Sbjct: 398 DVYFSYPTRPDEQIFRGFSLSIPSGTTVALVGQSGSGKSTVISLIERFYDPQLGDVLIDG 457
Query: 2448 NDIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCN 2269
++ ++ +R +G+V QEPVLF SI+ENI +GK +AT+QEI A + ANA F+
Sbjct: 458 VNLKEFQLRWIRSKIGLVSQEPVLFAASIKENIAYGKDNATDQEIRAAAELANASKFIDK 517
Query: 2268 FPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQK 2089
P G+ T VGE G QLSGGQKQRIAIAR ++++PRILLLDEATSALD ESE IVQEAL +
Sbjct: 518 MPQGLDTSVGEHGTQLSGGQKQRIAIARAILKDPRILLLDEATSALDAESERIVQEALDR 577
Query: 2088 ASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIA-MNGVYNNLVQTQLMSTN 1912
RTT++VAHRLST+RNA+ I V+ +G +VE G H +L+ G Y+ L++ Q +
Sbjct: 578 VMTNRTTVIVAHRLSTVRNADTIAVIHQGTLVEKGPHHELLKDPEGAYSQLIKLQEANRQ 637
Query: 1911 YEKMNENEE--------RVTRQSSHSDFPSNEISHQKIDQEDDYVKKLIAEIKEEGAKKS 1756
+ + + + + +S S S + SH + L +I++
Sbjct: 638 DKSDRKGDSGARSGKQLSINQSASRSRRSSRDNSHHSFSV--PFGMPLGIDIQD--GSSD 693
Query: 1755 NICE----------IIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKDE 1606
N+C+ + + E +L + + S I G+ +P+ + L+ +A+ ++
Sbjct: 694 NLCDGMPQDVPLSRLASLNKPEIPVLILGSIASVISGVIFPIFAILLSNVIKAF-YEPPH 752
Query: 1605 MLSK-SHFWALSILFLAFTRPIFIFF--QYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFY 1435
+L K S FW S +FL F F+ Y F +L ++R M+F+ ++++ ++
Sbjct: 753 LLRKDSQFW--SSMFLVFGAVYFLSLPVSSYLFSIAGCRLIKRIRLMTFEKVVNMEIEWF 810
Query: 1434 DDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMF 1255
D P +++ + RL+AD++ V V D L V+ ++ ++++F +W++SL +L
Sbjct: 811 DHPENSSGAIGARLSADAAKVRGLVGDALQLVVQNTTTLIAGLVIAFVSNWELSLIILAL 870
Query: 1254 CPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHL 1075
PL+ L G+ F+ + + +E++++ A +A+ ++RTV + + E +V+ L
Sbjct: 871 IPLIGLNGWIQMKFIQGFSADAKMMYEEASQVANDAVSSIRTVVSFSAEEKVMDLYKKKC 930
Query: 1074 QKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMT 895
+ + + +I G G + F +YA SF G LV + + V + L+M
Sbjct: 931 EGPLRTGIRTGIISGIGFGVSFFLLFGVYAASFYAGARLVEENKTTFPKVFRVFLALAMA 990
Query: 894 ASYAGSAVAYLPDHRKAIHAAGLIFHLFTYPA-IMPYDSSQGKRNIKNGEIELKNVSFEY 718
A + D KA A IF + + I P + + +G IE ++VSF Y
Sbjct: 991 AIGVSQSSTLTSDSSKAKSAVSSIFAIVDRKSRIDPSEDAGVTVETLHGNIEFQHVSFRY 1050
Query: 717 AQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDV 538
R D I + L + +G+T+ALVG SGSGKST ISLL+RFY G + +D ++
Sbjct: 1051 PTRPDVEIFRDLCLTIHSGKTVALVGESGSGKSTAISLLQRFYDPDVGHILLDGVDIQKF 1110
Query: 537 NLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSFVSQFPQGL 358
L LR+ + LVSQEP LFN +++ N +G A++ EI +A K+ANA F+S QG
Sbjct: 1111 QLKWLRQQMGLVSQEPALFNDTVRANIAYGKEGEATESEIIEAAKLANAHKFISSSHQGY 1170
Query: 357 DTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERL 178
T VGERGAQLSGGQKQRIAIARAI+++PK+LLLDEATSALD++SE+VVQ+ALD
Sbjct: 1171 GTTVGERGAQLSGGQKQRIAIARAIVKDPKILLLDEATSALDAESERVVQDALDRVMVNR 1230
Query: 177 STVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLR-KRSIYWRLV 40
+TV+VAHRLST+ NAD IAV+KNG + E+G H+ L+ K Y LV
Sbjct: 1231 TTVIVAHRLSTIQNADLIAVVKNGVIIEKGKHDTLMNIKDGAYASLV 1277