Homology by BLASTX
BLASTX 2.2.4 [Aug-26-2002]
Query= C47A10_1
(3841 letters)
Database: /home/niguts/usr02/tshini/ykclst/db/nr.seq
1,967,186 sequences; 661,712,633 total letters
Score E
Sequences producing significant alignments: (bits) Value
gi|17558664|ref|NP_507487.1| P-GlycoProtein related (pgp-9) [Cae... 2356 0.0
gi|39585393|emb|CAE61715.1| Hypothetical protein CBG05664 [Caeno... 2135 0.0
gi|39587899|emb|CAE67917.1| Hypothetical protein CBG13514 [Caeno... 1263 0.0
gi|17541710|ref|NP_502413.1| P-GlycoProtein related (pgp-1) [Cae... 1251 0.0
gi|283551|pir||S27337 multidrug resistance protein A - Caenorhab... 1251 0.0
gi|126924|sp|P21448|MDR1_CRIGR Multidrug resistance protein 1 (P... 1091 0.0
gi|72477|pir||DVHY1C multidrug resistance protein 1 - Chinese ha... 1088 0.0
gi|6755048|ref|NP_035206.1| ATP-binding cassette, sub-family B (... 1083 0.0
gi|266517|sp|P21447|MDR3_MOUSE Multidrug resistance protein 3 (P... 1083 0.0
gi|22775296|gb|AAN07779.1| multidrug resistance p-glycoprotein [... 1080 0.0
gi|31442763|gb|AAN07780.2| multidrug resistance p-glycoprotein [... 1078 0.0
gi|2506118|sp|P08183|MDR1_HUMAN Multidrug resistance protein 1 (... 1078 0.0
gi|42741659|ref|NP_000918.2| ATP-binding cassette sub-family B m... 1077 0.0
gi|46394984|gb|AAS91648.1| multidrug resistance protein; P-glyco... 1077 0.0
gi|307180|gb|AAA59575.1| P-glycoprotein [Homo sapiens] 1075 0.0
gi|25453402|ref|NP_596892.1| ATP-binding cassette, sub-family B ... 1075 0.0
gi|45382457|ref|NP_990225.1| ABC transporter protein [Gallus gal... 1073 0.0
gi|46394986|gb|AAS91649.1| multidrug resistance protein 1a; P-gl... 1072 0.0
gi|2353264|gb|AAB69423.1| P-glycoprotein [Homo sapiens] 1071 0.0
gi|2149087|gb|AAB58489.1| multidrug resistance protein-1 [Ovis a... 1068 0.0
gi|46394982|gb|AAS91647.1| multidrug resistance protein 1; P-gly... 1065 0.0
gi|8926217|gb|AAF81747.1| his-tagged-multidrug resistance glycop... 1065 0.0
gi|2852441|gb|AAC02113.1| multidrug resistance p-glycoprotein [C... 1063 0.0
gi|48267183|gb|AAQ63650.3| multi-drug resistance P-glycoprotein ... 1062 0.0
gi|22759019|gb|AAN05645.1| multidrug resistance p-glycoprotein [... 1061 0.0
gi|25453370|ref|NP_036755.2| P-glycoprotein/multidrug resistance... 1058 0.0
gi|126928|sp|P21449|MDR2_CRIGR Multidrug resistance protein 2 (P... 1053 0.0
gi|40644181|emb|CAC86600.1| multidrug resistance protein [Platic... 1051 0.0
gi|6755046|ref|NP_035205.1| ATP-binding cassette, sub-family B (... 1051 0.0
gi|4505771|ref|NP_000434.1| ATP-binding cassette, subfamily B, m... 1048 0.0
gi|191157|gb|AAA37005.1| p-glycoprotein 1048 0.0
gi|1362689|pir||S55692 multidrug resistance protein homolog (mdr... 1045 0.0
gi|833699|gb|AAA75000.1| multidrug resistance protein >gnl|BL_OR... 1045 0.0
gi|9961250|ref|NP_061337.1| ATP-binding cassette, subfamily B, m... 1042 0.0
gi|1170902|sp|P43245|MDR1_RAT Multidrug resistance protein 1 (P-... 1038 0.0
gi|6679297|ref|NP_032856.1| ATP-binding cassette, sub-family B (... 1034 0.0
gi|6981354|ref|NP_036822.1| ATP-binding cassette, sub-family B (... 1028 0.0
gi|50732589|ref|XP_418707.1| PREDICTED: similar to ATP-binding c... 1024 0.0
gi|126930|sp|P23174|MDR3_CRIGR Multidrug resistance protein 3 (P... 1023 0.0
gi|27656757|gb|AAO20901.1| Mdr3 [Takifugu rubripes] 1006 0.0
gi|39595370|emb|CAE60408.1| Hypothetical protein CBG04013 [Caeno... 1002 0.0
gi|25297453|pir||D87789 protein C34G6.4 [imported] - Caenorhabdi... 999 0.0
gi|72475|pir||DVMS1A multidrug resistance protein 1a - mouse (fr... 998 0.0
gi|17508505|ref|NP_491707.1| P-GlycoProtein related (pgp-2) [Cae... 997 0.0
gi|7511698|pir||T31073 multidrug resistance p-glycoprotein - nem... 988 0.0
gi|9961252|ref|NP_061338.1| ATP-binding cassette, subfamily B, m... 984 0.0
gi|6472653|dbj|BAA87071.1| multi-drug resistance related mRNA [F... 980 0.0
gi|17569143|ref|NP_509901.1| P-GlycoProtein related (pgp-3) [Cae... 962 0.0
gi|39594783|emb|CAE70651.1| Hypothetical protein CBG17356 [Caeno... 961 0.0
gi|17569145|ref|NP_509902.1| P-GlycoProtein related (pgp-4) [Cae... 955 0.0
gi|45361353|ref|NP_989254.1| hypothetical protein MGC76216 [Xeno... 954 0.0
gi|39594784|emb|CAE70652.1| Hypothetical protein CBG17357 [Caeno... 951 0.0
gi|283552|pir||S27338 P-glycoprotein C - Caenorhabditis elegans ... 942 0.0
gi|27656758|gb|AAO20902.1| Mdr2 [Takifugu rubripes] 938 0.0
gi|14030565|gb|AAK52958.1| bile salt export pump [Raja erinacea] 903 0.0
gi|22026798|ref|NP_523740.2| CG8523-PA [Drosophila melanogaster]... 896 0.0
gi|50507726|emb|CAA94219.3| Hypothetical protein T21E8.2 [Caenor... 894 0.0
gi|38073917|ref|XP_283101.2| similar to multidrug resistance p-g... 890 0.0
gi|17569909|ref|NP_509812.1| P-GlycoProtein related (pgp-7) [Cae... 888 0.0
gi|18496816|gb|AAL74249.1| ABC transporter AbcB2 [Dictyostelium ... 880 0.0
gi|40644167|emb|CAC86593.1| sister of P-glycoprotein [Platichthy... 877 0.0
gi|157873|gb|AAA16186.1| P-glycoprotein/multidrug resistance pro... 873 0.0
gi|1079107|pir||A47377 multidrug resistance protein Mdr50 - frui... 873 0.0
gi|17567269|ref|NP_510128.1| P-GlycoProtein related (146.8 kD) (... 870 0.0
gi|39587988|emb|CAE57219.1| Hypothetical protein CBG00079 [Caeno... 870 0.0
gi|4704820|gb|AAD28285.1| bile salt export pump [Homo sapiens] 868 0.0
gi|21536378|ref|NP_003733.2| ATP-binding cassette, sub-family B ... 867 0.0
gi|18496818|gb|AAL74250.1| ABC transporter AbcB3 [Dictyostelium ... 867 0.0
gi|12643301|sp|O95342|AB11_HUMAN Bile salt export pump (ATP-bind... 866 0.0
gi|13641444|gb|AAK31736.1| p-glycoprotein [Mucor racemosus] 863 0.0
gi|39594939|emb|CAE70807.1| Hypothetical protein CBG17569 [Caeno... 863 0.0
gi|17569907|ref|NP_509813.1| P-GlycoProtein related (pgp-6) [Cae... 862 0.0
gi|31213429|ref|XP_315658.1| ENSANGP00000021663 [Anopheles gambi... 860 0.0
gi|15226477|ref|NP_182223.1| multidrug resistant (MDR) ABC trans... 859 0.0
gi|11038656|ref|NP_066302.1| ATP-binding cassette, sub-family B,... 858 0.0
gi|17550138|ref|NP_509810.1| P-GlycoProtein related (pgp-5) [Cae... 858 0.0
gi|13929072|ref|NP_113948.1| ATP-binding cassette, sub-family B ... 858 0.0
gi|12585141|sp|Q9N0V3|AB11_RABIT Bile salt export pump (ATP-bind... 857 0.0
gi|7514034|pir||T42228 P-glycoprotein sister - rat >gnl|BL_ORD_I... 857 0.0
gi|48094917|ref|XP_394305.1| similar to ENSANGP00000021663 [Apis... 854 0.0
gi|15228695|ref|NP_191774.1| multidrug resistant (MDR) ABC trans... 851 0.0
gi|25146777|ref|NP_509811.2| P-GlycoProtein related (pgp-8) [Cae... 848 0.0
gi|39587992|emb|CAE57223.1| Hypothetical protein CBG00086 [Caeno... 847 0.0
gi|47225422|emb|CAG11905.1| unnamed protein product [Tetraodon n... 845 0.0
gi|39587990|emb|CAE57221.1| Hypothetical protein CBG00083 [Caeno... 839 0.0
gi|7511495|pir||T18940 multidrug resistance protein homolog - Ca... 837 0.0
gi|39594940|emb|CAE70808.1| Hypothetical protein CBG17570 [Caeno... 833 0.0
gi|17567265|ref|NP_510126.1| P-GlycoProtein related (pgp-12) [Ca... 833 0.0
gi|17567267|ref|NP_510127.1| P-GlycoProtein related (pgp-13) [Ca... 832 0.0
gi|14715462|dbj|BAB62040.1| CjMDR1 [Coptis japonica] 829 0.0
gi|39587987|emb|CAE57218.1| Hypothetical protein CBG00078 [Caeno... 827 0.0
gi|15217785|ref|NP_171753.1| multidrug resistance P-glycoprotein... 824 0.0
gi|15217786|ref|NP_171754.1| multidrug resistance P-glycoprotein... 822 0.0
gi|50750485|ref|XP_422016.1| PREDICTED: similar to liver bile sa... 820 0.0
gi|34894326|ref|NP_908488.1| unnamed protein product [Oryza sati... 820 0.0
gi|27368865|emb|CAD59590.1| MDR-like ABC transporter [Oryza sati... 820 0.0
gi|15234322|ref|NP_192091.1| multidrug resistance P-glycoprotein... 817 0.0
gi|15237456|ref|NP_199466.1| ABC transporter family protein [Ara... 817 0.0
gi|25455873|pir||T52319 P-glycoprotein-like protein pgp3 [import... 816 0.0
gi|17567271|ref|NP_510129.1| P-GlycoProtein related (pgp-15) [Ca... 816 0.0
gi|2673951|gb|AAB88657.1| multidrug resistance protein 1 [Asperg... 815 0.0
gi|422286|pir||S30328 multidrug resistance protein 2 - Entamoeba... 814 0.0
gi|15147363|gb|AAG01549.3| multidrug resistance protein MDR [Tri... 813 0.0
gi|25297456|pir||F86155 probable ABC transporter [imported] - Ar... 813 0.0
gi|19032275|dbj|BAB85651.1| multidrug resistance protein 1 homol... 813 0.0
gi|5456701|gb|AAD43626.1| multidrug resistance protein MDR [Emer... 811 0.0
gi|27368859|emb|CAD59587.1| MDR-like ABC transporter [Oryza sati... 810 0.0
gi|50543630|ref|XP_499981.1| hypothetical protein [Yarrowia lipo... 807 0.0
gi|266518|sp|Q00449|MDR4_DROME Multidrug resistance protein homo... 807 0.0
gi|24653245|ref|NP_523724.2| CG3879-PA [Drosophila melanogaster]... 806 0.0
gi|34913530|ref|NP_918112.1| putative multidrug resistance prote... 806 0.0
gi|25407562|pir||H85202 hypothetical protein AT4g18050 [imported... 805 0.0
gi|422285|pir||S30327 multidrug resistance protein 1 - Entamoeba... 804 0.0
gi|22328760|ref|NP_193539.2| ABC transporter family protein [Ara... 803 0.0
gi|49089458|ref|XP_406437.1| hypothetical protein AN2300.2 [Aspe... 800 0.0
gi|39595964|emb|CAE67467.1| Hypothetical protein CBG12969 [Caeno... 798 0.0
gi|22535563|dbj|BAC10738.1| putative multidrug resistance protei... 796 0.0
gi|15234323|ref|NP_192092.1| multidrug resistance P-glycoprotein... 793 0.0
gi|46390486|dbj|BAD15946.1| putative MDR-like ABC transporter [O... 791 0.0
gi|27368855|emb|CAD59585.1| MDR-like ABC transporter [Oryza sati... 788 0.0
gi|18033873|gb|AAL57243.1| ATP-binding cassette transporter ABC4... 786 0.0
gi|50260330|gb|EAL22989.1| hypothetical protein CNBA7570 [Crypto... 785 0.0
gi|49080124|ref|XP_403624.1| hypothetical protein UM06009.1 [Ust... 782 0.0
gi|11346278|pir||T43261 multidrug resistance protein 1 - fungus ... 778 0.0
gi|4574224|gb|AAD23956.1| multidrug resistance transporter homol... 771 0.0
gi|34911450|ref|NP_917072.1| putative multidrug resistance prote... 766 0.0
gi|15228052|ref|NP_181228.1| multidrug resistance P-glycoprotein... 764 0.0
gi|7442651|pir||T14805 hypothetical protein F15J5.20 - Arabidops... 764 0.0
gi|15228506|ref|NP_189528.1| multidrug resistance P-glycoprotein... 762 0.0
gi|22655312|gb|AAM98246.1| putative ABC transporter [Arabidopsis... 759 0.0
gi|26449438|dbj|BAC41846.1| putative P-glycoprotein [Arabidopsis... 759 0.0
gi|24324262|gb|AAN28720.2| MDR-like p-glycoprotein [Arabidopsis ... 758 0.0
gi|4204793|gb|AAD10836.1| P-glycoprotein [Solanum tuberosum] 757 0.0
gi|15217776|ref|NP_174115.1| multidrug resistance P-glycoprotein... 756 0.0
gi|27368851|emb|CAD59583.1| MDR-like ABC transporter [Oryza sati... 755 0.0
gi|34913544|ref|NP_918119.1| putative multidrug resistance prote... 754 0.0
gi|50546639|ref|XP_500789.1| hypothetical protein [Yarrowia lipo... 754 0.0
gi|21464386|gb|AAM51996.1| RE14657p [Drosophila melanogaster] 753 0.0
gi|17136662|ref|NP_476831.1| CG10181-PA [Drosophila melanogaster... 751 0.0
gi|103252|pir||B41249 multidrug resistance protein homolog Mdr65... 750 0.0
gi|20466380|gb|AAM20507.1| P-glycoprotein-2 [Arabidopsis thaliana] 749 0.0
gi|15236067|ref|NP_194326.1| multidrug resistance P-glycoprotein... 749 0.0
gi|393116|gb|AAA93553.1| P-glycoprotein 5 749 0.0
gi|50556486|ref|XP_505651.1| hypothetical protein [Yarrowia lipo... 749 0.0
gi|15217809|ref|NP_174122.1| multidrug resistance P-glycoprotein... 748 0.0
gi|27368847|emb|CAD59581.1| MDR-like ABC transporter [Oryza sati... 747 0.0
gi|39594943|emb|CAE70811.1| Hypothetical protein CBG17574 [Caeno... 745 0.0
gi|27368849|emb|CAD59582.1| MDR-like ABC transporter [Oryza sati... 745 0.0
gi|7508148|pir||T25082 hypothetical protein T21E8.2 - Caenorhabd... 744 0.0
gi|7493911|pir||T30882 multidrug resistance protein 1 - Aspergil... 742 0.0
gi|6671365|gb|AAF23176.1| P-glycoprotein [Gossypium hirsutum] 741 0.0
gi|46390962|dbj|BAD16475.1| putative multidrug resistance p-glyc... 737 0.0
gi|24659289|ref|NP_648040.1| CG10226-PA [Drosophila melanogaster... 733 0.0
gi|15232978|ref|NP_189480.1| P-glycoprotein, putative [Arabidops... 731 0.0
gi|38049160|gb|AAR10387.1| P-glycoprotein 1 [Sorghum bicolor] 730 0.0
gi|45735908|dbj|BAD12940.1| putative P-glycoprotein 1 [Oryza sat... 729 0.0
gi|21740907|emb|CAD40903.1| OSJNBa0036B21.21 [Oryza sativa (japo... 725 0.0
gi|9294577|dbj|BAB02858.1| multidrug resistance p-glycoprotein; ... 723 0.0
gi|15229473|ref|NP_189475.1| ABC transporter family protein [Ara... 723 0.0
gi|15220188|ref|NP_172538.1| P-glycoprotein, putative [Arabidops... 723 0.0
gi|27368861|emb|CAD59588.1| MDR-like ABC transporter [Oryza sati... 722 0.0
gi|7494503|pir||T30855 multidrug resistance protein 2 - fluke (S... 719 0.0
gi|22331385|ref|NP_683599.1| P-glycoprotein, putative [Arabidops... 718 0.0
gi|5733124|gb|AAD49436.1| P-glycoprotein [Onchocerca volvulus] 718 0.0
gi|7508147|pir||T25083 hypothetical protein T21E8.1 - Caenorhabd... 715 0.0
gi|27368845|emb|CAD59580.1| MDR-like ABC transporter [Oryza sati... 714 0.0
gi|15232977|ref|NP_189479.1| P-glycoprotein, putative [Arabidops... 711 0.0
gi|16304396|gb|AAL15148.1| multidrug resistance transporter-like... 708 0.0
gi|38345252|emb|CAD41096.2| OSJNBb0011N17.13 [Oryza sativa (japo... 707 0.0
gi|9294571|dbj|BAB02852.1| multidrug resistance p-glycoprotein; ... 704 0.0
gi|33307712|gb|AAQ03033.1| P-glycoprotein [Homo sapiens] 699 0.0
gi|7494131|pir||T30804 P-glycoprotein 6 - Entamoeba histolytica ... 698 0.0
gi|24960750|gb|AAN65444.1| Hypothetical protein [Oryza sativa (j... 697 0.0
gi|49092568|ref|XP_407745.1| hypothetical protein AN3608.2 [Aspe... 697 0.0
gi|27368867|emb|CAD59591.1| MDR-like ABC transporter [Oryza sati... 694 0.0
gi|15232975|ref|NP_189477.1| ABC transporter family protein [Ara... 693 0.0
gi|46111809|ref|XP_382962.1| hypothetical protein FG02786.1 [Gib... 689 0.0
gi|4587971|gb|AAD25925.1| ABC transporter protein AtrC [Emericel... 685 0.0
gi|37695542|gb|AAR00316.1| PGP1; ZMPGP1 [Zea mays] 684 0.0
gi|7442649|pir||T06165 multidrug resistance protein 1 homolog - ... 679 0.0
gi|38098857|gb|AAR11078.1| ATP binding cassette transporter [Lep... 679 0.0
gi|25297460|pir||B86240 protein F20B24.12 [imported] - Arabidops... 677 0.0
gi|27368869|emb|CAD59592.1| MDR-like ABC transporter [Oryza sati... 677 0.0
gi|36413607|ref|NP_848654.2| ATP-binding cassette, sub-family B,... 675 0.0
gi|46129276|ref|XP_388999.1| hypothetical protein FG08823.1 [Gib... 674 0.0
gi|27368839|emb|CAD59577.1| MDR-like ABC transporter [Oryza sati... 672 0.0
gi|37806003|dbj|BAC99416.1| putative MDR-like ABC transporter [O... 669 0.0
gi|34910738|ref|NP_916716.1| putative P-glycoprotein [Oryza sati... 667 0.0
gi|50732439|ref|XP_418636.1| PREDICTED: similar to Multidrug res... 664 0.0
gi|27368843|emb|CAD59579.1| MDR-like ABC transporter [Oryza sati... 651 0.0
gi|9294508|dbj|BAB02613.1| P-glycoprotein; multi-drug resistance... 651 0.0
gi|27368841|emb|CAD59578.1| MDR-like ABC transporter [Oryza sati... 649 0.0
gi|49089656|ref|XP_406486.1| hypothetical protein AN2349.2 [Aspe... 644 0.0
gi|2360941|gb|AAB69130.1| P-glycoprotein 641 0.0
gi|159363|gb|AAA02977.1| P-glycoprotein 636 e-180
gi|4521245|dbj|BAA76299.1| LAMDR1 [Leishmania mexicana amazonensis] 632 e-179
gi|5456699|gb|AAD43625.1| ATP-binding cassette multidrug transpo... 632 e-179
gi|730011|sp|Q06034|MDR1_LEIEN Multidrug resistance protein 1 (P... 626 e-177
gi|46109604|ref|XP_381860.1| hypothetical protein FG01684.1 [Gib... 620 e-176
gi|46125007|ref|XP_387057.1| hypothetical protein FG06881.1 [Gib... 620 e-175
gi|32402932|ref|XP_322079.1| hypothetical protein [Neurospora cr... 619 e-175
gi|7442650|pir||JG0166 LaMDR1 protein - Leishmania mexicana amaz... 619 e-175
gi|42820674|emb|CAF31987.1| ABC transporter, putative [Aspergill... 618 e-175
gi|20530737|gb|AAM27211.1| multidrug resistance protein 4 [Asper... 617 e-175
gi|7522025|pir||T30191 multidrug resistance protein 1 - Aureobas... 617 e-175
gi|33299999|emb|CAA88940.3| Hypothetical protein DH11.3 [Caenorh... 607 e-172
gi|49138261|ref|XP_413479.1| hypothetical protein AN9342.2 [Aspe... 600 e-169
gi|49081308|ref|XP_404076.1| hypothetical protein UM06461.1 [Ust... 598 e-169
gi|46114962|ref|XP_383499.1| hypothetical protein FG03323.1 [Gib... 593 e-168
gi|38101651|gb|EAA48581.1| hypothetical protein MG00239.4 [Magna... 591 e-167
gi|32400322|dbj|BAC78652.1| ABC transporter [Aspergillus oryzae] 585 e-165
gi|13346110|gb|AAK19598.1| putative ABC transporter [Sterkiella ... 579 e-163
gi|32418014|ref|XP_329485.1| hypothetical protein [Neurospora cr... 577 e-163
gi|18253111|dbj|BAB83959.1| multidrug resistance p-glycoprotein ... 575 e-162
gi|49097828|ref|XP_410374.1| hypothetical protein AN6237.2 [Aspe... 574 e-162
gi|49084736|ref|XP_404541.1| hypothetical protein AN0404.2 [Aspe... 562 e-158
gi|46116988|ref|XP_384512.1| hypothetical protein FG04336.1 [Gib... 555 e-156
gi|45775220|gb|AAK83023.2| truncated P-glycoprotein [Rattus norv... 550 e-155
gi|46401536|dbj|BAD16632.1| LAMDR2 [Leishmania amazonensis] 550 e-154
gi|191159|gb|AAA37006.1| P-glycoprotein (pgp1) 545 e-153
gi|46107316|ref|XP_380717.1| hypothetical protein FG00541.1 [Gib... 541 e-152
gi|38108326|gb|EAA54363.1| hypothetical protein MG02348.4 [Magna... 539 e-151
gi|18033871|gb|AAL57242.1| ATP-binding cassette transporter ABC3... 536 e-150
gi|72478|pir||DVHY2C multidrug resistance protein 2 - Chinese ha... 535 e-150
gi|4768949|gb|AAD29692.1| sister of P-glycoprotein [Fundulus het... 513 e-143
gi|191153|gb|AAA37003.1| p-glycoprotein 508 e-142
gi|25990364|gb|AAN76500.1| P-glycoprotein [Homo sapiens] 503 e-140
gi|38099353|gb|EAA46710.1| hypothetical protein MG09931.4 [Magna... 496 e-138
gi|34935680|ref|XP_234725.2| similar to P-glycoprotein [Rattus n... 489 e-136
gi|45735907|dbj|BAD12939.1| putative P-glycoprotein 1 [Oryza sat... 486 e-135
gi|47225423|emb|CAG11906.1| unnamed protein product [Tetraodon n... 485 e-135
gi|47212418|emb|CAG12367.1| unnamed protein product [Tetraodon n... 480 e-133
gi|17551158|ref|NP_509205.1| P-GlycoProtein related (pgp-10) [Ca... 462 e-128
gi|47218631|emb|CAG04960.1| unnamed protein product [Tetraodon n... 441 e-122
gi|45735909|dbj|BAD12941.1| putative P-glycoprotein 1 [Oryza sat... 427 e-118
gi|19075765|ref|NP_588265.1| leptomycin b resistance protein, ab... 421 e-116
gi|218550|dbj|BAA01537.1| pmd1 protein [Schizosaccharomyces pombe] 421 e-116
gi|34525|emb|CAA29547.1| P-glycoprotein (431 AA) [Homo sapiens] 408 e-112
gi|1174535|gb|AAA86666.1| ATP-binding cassette protein [Fasciola... 384 e-105
gi|5733401|gb|AAD49563.1| P-glycoprotein-like protein [Onchocerc... 384 e-105
gi|47900485|gb|AAT39242.1| putative P-glycoprotein [Oryza sativa... 384 e-105
gi|18875456|gb|AAL74251.2| ABC transporter AbcB4 [Dictyostelium ... 369 e-100
gi|41052996|dbj|BAD07905.1| putative MDR-like ABC transporter [O... 360 1e-97
gi|18124158|gb|AAL59848.1| ATP-binding cassette protein 3 [Crypt... 357 2e-96
gi|32399046|emb|CAD98286.1| ATP-binding cassette transporter [Cr... 357 2e-96
gi|12278525|gb|AAG49002.1| putative ABC transporter [Hordeum vul... 337 1e-90
gi|18496654|gb|AAL74186.1| putative ABC transporter [Triticum mo... 337 2e-90
gi|17511077|ref|NP_491754.1| HAlF transporter, PGP related (90.8... 337 2e-90
gi|7511165|pir||T32865 hypothetical protein ZK484.2 - Caenorhabd... 337 2e-90
gi|39580953|emb|CAE72923.1| Hypothetical protein CBG20243 [Caeno... 336 3e-90
gi|19698967|gb|AAL91219.1| P-glycoprotein, putative [Arabidopsis... 335 7e-90
gi|15233244|ref|NP_191092.1| ABC transporter family protein [Ara... 333 2e-89
gi|27368853|emb|CAD59584.1| MDR-like ABC transporter [Oryza sati... 333 2e-89
gi|12278526|gb|AAG49003.1| putative ABC transporter [Hordeum vul... 332 3e-89
gi|18496655|gb|AAL74187.1| putative ABC transporter [Triticum mo... 332 3e-89
gi|4156146|gb|AAD05023.1| unknown [Homo sapiens] 331 7e-89
gi|39586807|emb|CAE65850.1| Hypothetical protein CBG10984 [Caeno... 331 7e-89
gi|17543740|ref|NP_502776.1| HAlF transporter, PGP related (haf-... 330 1e-88
gi|12061244|gb|AAG45492.1| 36I5.4 [Oryza sativa (japonica cultiv... 330 1e-88
gi|18496814|gb|AAL74248.1| ABC transporter AbcB1 [Dictyostelium ... 329 4e-88
gi|39587763|emb|CAE67781.1| Hypothetical protein CBG13356 [Caeno... 328 5e-88
gi|21326114|gb|AAM47580.1| putative ABC-transporter-like protein... 328 6e-88
gi|19335724|gb|AAL85486.1| transporter associated with antigen p... 328 8e-88
gi|22327455|ref|NP_198720.2| ABC transporter (TAP2) [Arabidopsis... 328 8e-88
gi|10177549|dbj|BAB10828.1| ABC transporter-like protein [Arabid... 328 8e-88
gi|34853987|ref|XP_342615.1| similar to RIKEN cDNA 4833412N02 [R... 327 2e-87
gi|17509565|ref|NP_490739.1| HAlF transporter, PGP related (haf-... 327 2e-87
gi|27452581|gb|AAN71739.1| ABCB9-like TAP-family protein [Petrom... 325 5e-87
gi|39579434|emb|CAE74830.1| Hypothetical protein CBG22668 [Caeno... 325 5e-87
gi|27753995|ref|NP_083296.2| RIKEN cDNA 4833412N02 [Mus musculus... 324 9e-87
gi|26339816|dbj|BAC33571.1| unnamed protein product [Mus musculus] 324 9e-87
gi|39583384|emb|CAE66359.1| Hypothetical protein CBG11616 [Caeno... 324 1e-86
gi|10241621|emb|CAC09461.1| putative P-glycoprotein [Oryza sativ... 323 2e-86
gi|26345292|dbj|BAC36297.1| unnamed protein product [Mus musculus] 323 3e-86
gi|37676347|ref|NP_936743.1| ABC-type multidrug transport system... 322 3e-86
gi|32966961|gb|AAP92331.1| multixenobiotic resistance protein [C... 322 6e-86
gi|9506367|ref|NP_062425.1| ATP-binding cassette, sub-family B, ... 322 6e-86
gi|7023646|dbj|BAA92038.1| unnamed protein product [Homo sapiens] 321 1e-85
gi|17532731|ref|NP_495674.1| P-GlycoProtein related (pgp-11) [Ca... 320 1e-85
gi|27366635|ref|NP_762162.1| ABC-type multidrug transport system... 320 1e-85
gi|34851887|ref|XP_341718.1| similar to ABC transporter [Rattus ... 320 1e-85
gi|21753735|dbj|BAC04392.1| unnamed protein product [Homo sapiens] 318 5e-85
gi|27376619|ref|NP_768148.1| HlyB/MsbA family ABC transporter [B... 318 8e-85
gi|20453064|gb|AAM19777.1| At2g39480/F12L6.14 [Arabidopsis thali... 317 1e-84
gi|15225474|ref|NP_181480.1| ABC transporter family protein [Ara... 317 1e-84
gi|22974777|ref|ZP_00020923.1| hypothetical protein [Chloroflexu... 316 2e-84
gi|6005804|ref|NP_009119.1| ATP-binding cassette, sub-family B, ... 315 5e-84
gi|13123950|sp|Q9NUT2|ABC8_HUMAN ATP-binding cassette, sub-famil... 315 5e-84
gi|39581765|emb|CAE74138.1| Hypothetical protein CBG21809 [Caeno... 314 9e-84
gi|17565938|ref|NP_506645.1| HAlF transporter, PGP related (haf-... 313 2e-83
gi|7510080|pir||T31617 hypothetical protein Y50E8A.m - Caenorhab... 313 2e-83
gi|9961244|ref|NP_036221.1| ATP-binding cassette, sub-family B, ... 313 2e-83
gi|40787796|gb|AAH64930.1| ATP-binding cassette, sub-family B, m... 312 3e-83
gi|1743404|emb|CAB05917.1| transport-associated protein [Salmo s... 311 1e-82
gi|28900647|ref|NP_800302.1| putative ATP-binding/permease fusio... 311 1e-82
gi|34496280|ref|NP_900495.1| transport ATP-binding protein msbA ... 310 1e-82
gi|5911322|gb|AAD55751.1| transporter associated with antigen pr... 310 1e-82
gi|49474685|ref|YP_032727.1| ABC transporter, ATP-binding protei... 310 2e-82
gi|37781028|gb|AAP36720.1| transporter associated with antigen p... 309 3e-82
gi|23469088|ref|ZP_00124423.1| COG1132: ABC-type multidrug trans... 309 3e-82
gi|24641565|ref|NP_572810.1| CG1824-PA [Drosophila melanogaster]... 309 4e-82
gi|7498268|pir||T20386 hypothetical protein DH11.3 - Caenorhabdi... 309 4e-82
gi|49476161|ref|YP_034202.1| ABC transporter, ATP-binding protei... 309 4e-82
gi|17533971|ref|NP_495537.1| HAlF transporter, PGP related (haf-... 308 9e-82
gi|39582351|emb|CAE67600.1| Hypothetical protein CBG13145 [Caeno... 308 9e-82
gi|9992887|gb|AAG11416.1| TagA [Dictyostelium discoideum] 306 2e-81
gi|5823084|gb|AAD53033.1| TAP1 protein [Oncorhynchus mykiss] 306 2e-81
gi|31216972|ref|XP_316337.1| ENSANGP00000013796 [Anopheles gambi... 306 2e-81
gi|34906082|ref|NP_914388.1| putative P-glycoprotein [Oryza sati... 306 2e-81
gi|12248755|dbj|BAB20265.1| mono ATP-binding cassette protein [H... 306 2e-81
gi|31206493|ref|XP_312209.1| ENSANGP00000002692 [Anopheles gambi... 305 6e-81
gi|15966528|ref|NP_386881.1| PROBABLE ABC TRANSPORTER ATP-BINDIN... 304 9e-81
gi|9955966|ref|NP_062571.1| ATP-binding cassette, sub-family B (... 304 9e-81
gi|39933996|ref|NP_946272.1| ABC transporter, ATP-binding protei... 304 9e-81
gi|28869225|ref|NP_791844.1| ABC transporter, ATP-binding/permea... 303 2e-80
gi|48850584|ref|ZP_00304826.1| COG1132: ABC-type multidrug trans... 303 3e-80
gi|26006275|dbj|BAC41480.1| mKIAA1520 protein [Mus musculus] 301 6e-80
gi|22095457|sp|Q9JJ59|ABC9_MOUSE ATP-binding cassette, sub-famil... 301 6e-80
gi|11560034|ref|NP_071574.1| TAP-like ABC transporter [Rattus no... 301 8e-80
gi|9845230|ref|NP_063928.1| ATP-binding cassette, sub-family B, ... 301 8e-80
gi|23397593|ref|NP_569844.2| CG3156-PA [Drosophila melanogaster]... 301 1e-79
gi|30698733|ref|NP_177218.3| ABC transporter (TAP1) [Arabidopsis... 300 2e-79
gi|21242281|ref|NP_641863.1| ABC transporter ATP-binding protein... 299 3e-79
gi|39992420|gb|AAH64384.1| ABCB9 protein [Homo sapiens] 299 4e-79
gi|18124194|gb|AAL59859.1| transporter associated with antigen p... 299 4e-79
gi|22971760|ref|ZP_00018688.1| hypothetical protein [Chloroflexu... 298 5e-79
gi|48730042|ref|ZP_00263791.1| COG1132: ABC-type multidrug trans... 298 5e-79
gi|27452473|gb|AAN71740.1| ABCB9-like TAP-family protein [Petrom... 298 7e-79
gi|46913988|emb|CAG20770.1| putative transport ATP-binding prote... 297 1e-78
gi|5911326|gb|AAD55753.1| transporter associated with antigen pr... 297 1e-78
gi|5823088|gb|AAD53035.1| TAP2B protein [Oncorhynchus mykiss] 296 2e-78
gi|32563749|ref|NP_871812.1| HAlF transporter, PGP related (haf-... 296 2e-78
gi|1743406|emb|CAB05918.1| transport-associated protein [Salmo s... 296 2e-78
gi|46916508|emb|CAG23273.1| putative ATP-binding/permease fusion... 296 3e-78
gi|42657938|ref|XP_377933.1| similar to MGC76216 protein [Homo s... 296 3e-78
gi|22959359|ref|ZP_00007012.1| COG1132: ABC-type multidrug trans... 296 3e-78
gi|16127504|ref|NP_422068.1| ABC transporter, HlyB/MsbA family [... 295 4e-78
gi|28199828|ref|NP_780142.1| ABC transporter ATP-binding protein... 295 4e-78
gi|7445902|pir||T13416 hypothetical protein 171D11.2 - fruit fly... 295 8e-78
gi|22997178|ref|ZP_00041414.1| COG1132: ABC-type multidrug trans... 294 1e-77
gi|47575345|ref|ZP_00245380.1| COG1132: ABC-type multidrug trans... 294 1e-77
gi|2147880|pir||I48120 P-glycoprotein - Chinese hamster (fragmen... 293 2e-77
gi|45916934|ref|ZP_00195995.2| COG1132: ABC-type multidrug trans... 293 2e-77
gi|21230937|ref|NP_636854.1| ABC transporter ATP-binding protein... 293 3e-77
gi|2119779|pir||S50217 multidrug resistance protein 3 - rat (fra... 292 4e-77
gi|22995060|ref|ZP_00039543.1| COG1132: ABC-type multidrug trans... 292 4e-77
gi|21673056|ref|NP_661121.1| ABC transporter, ATP-binding protei... 292 5e-77
gi|15596310|ref|NP_249804.1| probable ATP-binding/permease fusio... 291 1e-76
gi|32041123|ref|ZP_00138706.1| COG1132: ABC-type multidrug trans... 290 1e-76
gi|29561855|emb|CAD87788.1| SI:dZ262K18.3 (ATP-binding cassette,... 290 2e-76
gi|50121481|ref|YP_050648.1| lipid a export ATP-binding/permease... 289 3e-76
gi|8176565|dbj|BAA96370.1| ABC protein [Physarum polycephalum] 289 3e-76
gi|34906862|ref|NP_914778.1| putative ABC transporter [Oryza sat... 288 5e-76
gi|46119497|ref|ZP_00176704.2| COG1132: ABC-type multidrug trans... 288 5e-76
gi|26988843|ref|NP_744268.1| ABC efflux transporter, permease/AT... 288 7e-76
gi|15839171|ref|NP_299859.1| ABC transporter ATP-binding protein... 287 1e-75
gi|24112322|ref|NP_706832.1| ATP-binding transport protein; mult... 287 1e-75
gi|26246941|ref|NP_752981.1| Probable transport ATP-binding prot... 287 1e-75
gi|30249744|ref|NP_841814.1| ABC transporter, fused permease and... 287 1e-75
gi|4321799|gb|AAD15830.1| TAP2 protein [Xenopus laevis] 287 2e-75
gi|13473363|ref|NP_104930.1| ABC transporter, ATP-binding protei... 287 2e-75
gi|15800775|ref|NP_286789.1| ATP-binding transport protein; mult... 287 2e-75
gi|2147879|pir||I48119 P-glycoprotein - Chinese hamster (fragmen... 286 2e-75
gi|15602726|ref|NP_245798.1| MsbA [Pasteurella multocida Pm70] >... 286 3e-75
gi|33636348|dbj|BAC81752.1| hydrophobic compound transport facto... 286 3e-75
gi|25406058|pir||C96730 probable ABC transporter F5A18.21 [impor... 285 5e-75
gi|15891205|ref|NP_356877.1| AGR_L_2179p [Agrobacterium tumefaci... 285 6e-75
gi|23502573|ref|NP_698700.1| ABC transporter, ATP binding/permea... 285 8e-75
gi|16759854|ref|NP_455471.1| probable transport ATP-binding prot... 284 1e-74
gi|525293|emb|CAA53758.1| PGP1 [Trichomonas vaginalis] 283 2e-74
gi|17986606|ref|NP_539240.1| PROBABLE TRANSPORT ATP-BINDING PROT... 283 3e-74
gi|48732123|ref|ZP_00265866.1| COG1132: ABC-type multidrug trans... 283 3e-74
gi|49077780|ref|XP_402711.1| hypothetical protein UM05096.1 [Ust... 282 4e-74
gi|39579610|emb|CAE56497.1| Hypothetical protein CBG24214 [Caeno... 282 5e-74
gi|37525574|ref|NP_928918.1| Probable transport ATP-binding prot... 281 7e-74
gi|48864170|ref|ZP_00318063.1| COG1132: ABC-type multidrug trans... 281 7e-74
gi|2232172|gb|AAB62237.1| TAP2 [Oncorhynchus mykiss] 281 9e-74
gi|5823086|gb|AAD53034.1| TAP2 protein [Oncorhynchus mykiss] 281 9e-74
gi|47217174|emb|CAG11010.1| unnamed protein product [Tetraodon n... 280 1e-73
gi|50551833|ref|XP_503391.1| hypothetical protein [Yarrowia lipo... 280 3e-73
gi|15616453|ref|NP_244759.1| ABC transporter (ATP-binding protei... 279 3e-73
gi|47077792|dbj|BAD18770.1| unnamed protein product [Homo sapiens] 279 3e-73
gi|46133688|ref|ZP_00157567.2| COG1132: ABC-type multidrug trans... 279 4e-73
gi|47215340|emb|CAG12574.1| unnamed protein product [Tetraodon n... 279 4e-73
gi|16121675|ref|NP_404988.1| probable transport ATP-binding prot... 278 6e-73
gi|45441025|ref|NP_992564.1| probable transport ATP-binding prot... 278 6e-73
gi|425474|gb|AAA66476.1| SMDR1 278 7e-73
gi|27365418|ref|NP_760946.1| Transport ATP-binding protein MsbA ... 278 7e-73
gi|37680540|ref|NP_935149.1| transport ATP-binding protein MsbA ... 277 1e-72
gi|47225421|emb|CAG11904.1| unnamed protein product [Tetraodon n... 277 1e-72
gi|50510160|dbj|BAD31127.1| putative ATP-binding cassette, sub-f... 277 2e-72
gi|21622336|emb|CAD36977.1| probable multidrug resistance protei... 276 2e-72
gi|45199202|ref|NP_986231.1| AFR683Cp [Eremothecium gossypii] >g... 276 3e-72
gi|15600190|ref|NP_253684.1| transport protein MsbA [Pseudomonas... 276 4e-72
gi|16272034|ref|NP_438233.1| ABC transporter ATP-binding protein... 275 5e-72
gi|28210179|ref|NP_781123.1| multidrug resistance ABC transporte... 275 6e-72
gi|24374337|ref|NP_718380.1| ABC transporter, ATP-binding protei... 275 8e-72
gi|15643057|ref|NP_228100.1| ABC transporter, ATP-binding protei... 275 8e-72
gi|24375163|ref|NP_719206.1| ABC transporter, ATP-binding/permea... 274 1e-71
gi|22760375|dbj|BAC11171.1| unnamed protein product [Homo sapiens] 273 2e-71
gi|34901502|ref|NP_912097.1| contains ESTs C74558(E31852),AU0948... 273 2e-71
gi|17230327|ref|NP_486875.1| ATP-binding protein; heterocyst dif... 273 2e-71
gi|50085455|ref|YP_046965.1| lipid transport protein, flippase (... 273 2e-71
gi|2625135|gb|AAC32400.1| heterocyst differentiation protein [No... 273 2e-71
gi|28211454|ref|NP_782398.1| multidrug resistance ABC transporte... 273 2e-71
gi|46396288|sp|Q47908|MSBA_FRANO Lipid A export ATP-binding/perm... 273 2e-71
gi|290801|gb|AAD15237.1| member of super-family of ABC proteins 273 2e-71
gi|33302629|sp|Q9CHL8|LMRA_LACLA Multidrug resistance ABC transp... 273 3e-71
gi|15672693|ref|NP_266867.1| multidrug resistance ABC transporte... 273 3e-71
gi|17561534|ref|NP_506927.1| HAlF transporter, PGP related (haf-... 273 3e-71
gi|6093552|gb|AAB58724.2| TAP2 [Mesocricetus auratus] 272 4e-71
gi|6093548|gb|AAB58722.2| TAP2 [Mesocricetus auratus] 272 4e-71
gi|29654183|ref|NP_819875.1| ABC transporter, ATP-binding/permea... 271 9e-71
gi|23129118|ref|ZP_00110951.1| COG1132: ABC-type multidrug trans... 271 1e-70
gi|481258|pir||S38400 mt2 protein - rat >gnl|BL_ORD_ID|997578 gi... 270 2e-70
gi|37781024|gb|AAP36718.1| transporter associated with antigen p... 270 2e-70
gi|26991613|ref|NP_747038.1| lipid/phospholipid ABC efflux trans... 270 2e-70
gi|15808008|ref|NP_285672.1| ABC transporter, ATP-binding protei... 270 2e-70
gi|15963913|ref|NP_384266.1| PUTATIVE ATP-BINDING ABC TRANSPORTE... 270 3e-70
gi|14091734|ref|NP_114445.1| transporter 2, ATP-binding cassette... 270 3e-70
gi|2673955|gb|AAB88659.1| multidrug resistance protein 2 [Asperg... 269 3e-70
gi|23104911|ref|ZP_00091371.1| COG1132: ABC-type multidrug trans... 269 3e-70
gi|45506572|ref|ZP_00158925.1| COG1132: ABC-type multidrug trans... 269 4e-70
gi|16080776|ref|NP_391604.1| ywjA [Bacillus subtilis subsp. subt... 268 6e-70
gi|50304659|ref|XP_452285.1| unnamed protein product [Kluyveromy... 268 6e-70
gi|2492605|sp|P97998|MDL1_CANAL ATP-dependent permease MDL1 >gnl... 268 8e-70
gi|46440040|gb|EAK99351.1| hypothetical protein CaO19.2615 [Cand... 268 8e-70
gi|18309509|ref|NP_561443.1| probable ABC transporter [Clostridi... 268 8e-70
gi|23016084|ref|ZP_00055844.1| COG1132: ABC-type multidrug trans... 268 8e-70
gi|860725|gb|AAA96713.1| major histocompatibility complex class I 268 1e-69
gi|12325039|gb|AAG52466.1| putative ABC transporter; 73228-76244... 267 2e-69
gi|15613276|ref|NP_241579.1| ABC transporter (ATP-binding protei... 267 2e-69
gi|19112543|ref|NP_595751.1| putative permease [Schizosaccharomy... 267 2e-69
gi|46396386|sp|Q87VF3|MSBA_PSESM Lipid A export ATP-binding/perm... 266 2e-69
gi|28872098|ref|NP_794717.1| lipid A ABC transporter, ATP-bindin... 266 2e-69
gi|6323217|ref|NP_013289.1| ATP-binding cassette (ABC) transport... 266 2e-69
gi|50259844|gb|EAL22512.1| hypothetical protein CNBB3900 [Crypto... 266 2e-69
gi|30519701|emb|CAD90041.1| putative ATP-binding cassette transp... 266 3e-69
gi|46188744|ref|ZP_00205794.1| COG1132: ABC-type multidrug trans... 266 3e-69
gi|18124191|gb|AAL59858.1| transporter associated with antigen p... 266 3e-69
gi|16330032|ref|NP_440760.1| ABC transporter [Synechocystis sp. ... 265 5e-69
gi|111975|pir||S25576 probable transport protein mt2 - rat >gnl|... 265 5e-69
gi|407481|emb|CAA53055.1| TAP2 [Rattus norvegicus] 265 5e-69
gi|39997358|ref|NP_953309.1| ABC transporter, ATP-binding protei... 265 5e-69
gi|17228079|ref|NP_484627.1| ATP-binding protein of ABC transpor... 265 6e-69
gi|16330165|ref|NP_440893.1| ABC transporter [Synechocystis sp. ... 265 6e-69
gi|50306267|ref|XP_453105.1| unnamed protein product [Kluyveromy... 265 6e-69
gi|46237563|emb|CAE83943.1| transporter 2, ATP-binding cassette,... 265 8e-69
gi|33302625|sp|P97046|LMRA_LACLC Multidrug resistance ABC transp... 264 1e-68
gi|28897756|ref|NP_797361.1| transport ATP-binding protein MsbA ... 264 1e-68
gi|17228136|ref|NP_484684.1| ATP-binding protein of ABC transpor... 264 1e-68
gi|295584|gb|AAA20681.1| Mdl1p 264 1e-68
gi|23127481|ref|ZP_00109350.1| COG1132: ABC-type multidrug trans... 264 1e-68
gi|34392381|dbj|BAC82518.1| Transporter associated with antigen ... 264 1e-68
gi|16080535|ref|NP_391362.1| yvcC [Bacillus subtilis subsp. subt... 264 1e-68
gi|50121342|ref|YP_050509.1| putative ABC transporter ATP-bindin... 264 1e-68
gi|26788076|emb|CAD58755.1| SI:dZ172P2.4 (novel protein similar ... 263 2e-68
gi|42527766|ref|NP_972864.1| ABC transporter, ATP-binding/permea... 263 2e-68
gi|28379405|ref|NP_786297.1| multidrug ABC transporter, ATP-bind... 263 2e-68
gi|16797793|dbj|BAA83673.2| TAP2 [Coturnix japonica] 263 2e-68
gi|39580004|emb|CAE56320.1| Hypothetical protein CBG23985 [Caeno... 263 2e-68
gi|49479314|ref|YP_036563.1| multidrug resistance ABC transporte... 263 2e-68
gi|45521342|ref|ZP_00172862.1| COG1132: ABC-type multidrug trans... 263 3e-68
gi|48855938|ref|ZP_00310096.1| COG1132: ABC-type multidrug trans... 262 4e-68
gi|30262443|ref|NP_844820.1| ABC transporter, ATP-binding/permea... 262 4e-68
gi|15641880|ref|NP_231512.1| transport ATP-binding protein MsbA ... 261 7e-68
gi|48892154|ref|ZP_00325566.1| COG1132: ABC-type multidrug trans... 261 7e-68
gi|15924856|ref|NP_372390.1| ABC transporter homolog [Staphyloco... 261 7e-68
gi|22298505|ref|NP_681752.1| ABC transporter ATP-binding protein... 261 7e-68
gi|48833973|ref|ZP_00290989.1| COG1132: ABC-type multidrug trans... 261 7e-68
gi|46192477|ref|ZP_00207293.1| COG1132: ABC-type multidrug trans... 261 9e-68
gi|24216393|ref|NP_713874.1| Probable transport ATP-binding prot... 261 9e-68
gi|45506769|ref|ZP_00159120.1| COG1132: ABC-type multidrug trans... 261 1e-67
gi|48844191|ref|ZP_00298519.1| COG1132: ABC-type multidrug trans... 261 1e-67
gi|30020503|ref|NP_832134.1| Multidrug resistance ABC transporte... 260 2e-67
gi|17229638|ref|NP_486186.1| ATP-binding protein of ABC transpor... 260 2e-67
gi|23100898|ref|NP_694365.1| ABC transporter ATP-binding protein... 260 2e-67
gi|45656430|ref|YP_000516.1| ABC transporter, ATP-binding protei... 259 3e-67
gi|15896526|ref|NP_349875.1| ABC-type multidrug/protein/lipid tr... 259 3e-67
gi|21400315|ref|NP_656300.1| ABC_tran, ABC transporter [Bacillus... 259 3e-67
gi|48870952|ref|ZP_00323669.1| COG1132: ABC-type multidrug trans... 259 3e-67
gi|33152665|ref|NP_874018.1| ABC transporter ATP-binding protein... 259 3e-67
gi|20807317|ref|NP_622488.1| ABC-type multidrug/protein/lipid tr... 259 5e-67
gi|1743408|emb|CAB05919.1| transport-associated protein [Salmo s... 259 5e-67
gi|17988594|ref|NP_541227.1| ABC TRANSPORTER ATP-BINDING PROTEIN... 258 6e-67
gi|48857925|ref|ZP_00311899.1| COG1132: ABC-type multidrug trans... 258 6e-67
gi|34148119|gb|AAQ62607.1| transporter associated with antigen p... 258 6e-67
gi|47570138|ref|ZP_00240795.1| ABC transporter, ATP-binding/perm... 258 6e-67
gi|42781537|ref|NP_978784.1| ABC transporter, ATP-binding/permea... 258 6e-67
gi|23500772|ref|NP_700212.1| ABC transporter, ATP-binding/permea... 258 6e-67
gi|47567391|ref|ZP_00238104.1| ABC transporter, ATP-binding/perm... 258 8e-67
gi|46113651|ref|ZP_00183228.2| COG1132: ABC-type multidrug trans... 258 8e-67
gi|23113832|ref|ZP_00099175.1| COG1132: ABC-type multidrug trans... 258 8e-67
gi|23098860|ref|NP_692326.1| ABC transporter ATP-binding protein... 258 1e-66
gi|23467052|ref|ZP_00122637.1| COG1132: ABC-type multidrug trans... 258 1e-66
gi|46141086|ref|ZP_00203861.1| COG1132: ABC-type multidrug trans... 258 1e-66
gi|7512231|pir||T28151 probable ABC-type transport protein TAP2 ... 258 1e-66
gi|15672293|ref|NP_266467.1| ABC transporter ATP binding and per... 258 1e-66
gi|18478983|dbj|BAB84549.1| ABCB3 [Oryzias latipes] 258 1e-66
gi|21397643|ref|NP_653628.1| ABC_tran, ABC transporter [Bacillus... 257 1e-66
>gi|17558664|ref|NP_507487.1| P-GlycoProtein related (pgp-9)
[Caenorhabditis elegans]
gi|7497530|pir||T19982 hypothetical protein C47A10.1 - Caenorhabditis
elegans
gi|3875004|emb|CAB03973.1| Hypothetical protein C47A10.1
[Caenorhabditis elegans]
gi|3879215|emb|CAB07855.1| Hypothetical protein C47A10.1
[Caenorhabditis elegans]
Length = 1294
Score = 2356 bits (6106), Expect = 0.0
Identities = 1212/1266 (95%), Positives = 1212/1266 (95%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA
Sbjct: 29 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 88
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR
Sbjct: 89 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 148
Query: 401 QEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLI 580
QEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLI
Sbjct: 149 QEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLI 208
Query: 581 MMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRY 760
MMSLSPFMMICGLF QYAVAGGIAEEVLTSIRTVIAFNGQEYECKRY
Sbjct: 209 MMSLSPFMMICGLFLAKLLATAATKEAKQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRY 268
Query: 761 EDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFS 940
EDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFS
Sbjct: 269 EDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFS 328
Query: 941 VMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKV 1120
VMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKV
Sbjct: 329 VMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKV 388
Query: 1121 EFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIP 1300
EFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIP
Sbjct: 389 EFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIP 448
Query: 1301 IEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFP 1480
IEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFP
Sbjct: 449 IEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFP 508
Query: 1481 EGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENAS 1660
EGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENAS
Sbjct: 509 EGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENAS 568
Query: 1661 RGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVDDK 1840
RGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVDDK
Sbjct: 569 RGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVDDK 628
Query: 1841 PKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXGAV 2020
PKKKEAERRMSRQTSQRKGSVNFKTQESQVD GAV
Sbjct: 629 PKKKEAERRMSRQTSQRKGSVNFKTQESQVDEKPGAPPAPEAAEKEIKRLKKELEEEGAV 688
Query: 2021 KANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHF 2200
KANLFKILRYARPEWIY LIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHF
Sbjct: 689 KANLFKILRYARPEWIYIFFAIIAALIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHF 748
Query: 2201 WALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRI 2380
WALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRI
Sbjct: 749 WALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRI 808
Query: 2381 TTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQAL 2560
TTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQAL
Sbjct: 809 TTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQAL 868
Query: 2561 MMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISK 2740
MMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISK
Sbjct: 869 MMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISK 928
Query: 2741 AIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAA 2920
AIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAA
Sbjct: 929 AIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAA 988
Query: 2921 SYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVFFRYPERPAVPIL 3100
SYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVFFRYPERPAVPIL
Sbjct: 989 SYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVFFRYPERPAVPIL 1048
Query: 3101 QGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHI 3280
QGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHI
Sbjct: 1049 QGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHI 1108
Query: 3281 ALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKG 3460
ALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKG
Sbjct: 1109 ALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKG 1168
Query: 3461 TQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHR 3640
TQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHR
Sbjct: 1169 TQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHR 1228
Query: 3641 LSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSSNQSGGAFDTSEALXXXX 3820
LSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSSNQSGGAFDTSEAL
Sbjct: 1229 LSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSSNQSGGAFDTSEALDDDD 1288
Query: 3821 XXHVKF 3838
HVKF
Sbjct: 1289 DDHVKF 1294
>gi|39585393|emb|CAE61715.1| Hypothetical protein CBG05664
[Caenorhabditis briggsae]
Length = 1294
Score = 2135 bits (5533), Expect = 0.0
Identities = 1085/1267 (85%), Positives = 1158/1267 (90%), Gaps = 1/1267 (0%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
ISIFQL+RYTST+DR+ML VGI+VSCATG+GLPLMSIIMGNVSQNFV +GTI ++ A
Sbjct: 30 ISIFQLFRYTSTMDRIMLIVGILVSCATGLGLPLMSIIMGNVSQNFVEIGTILMNSTDPA 89
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
K A + +FSH+VIQNCL+YVYLG GIFAAG +QASCF++ICE LSNRFRR+FF+SVMR
Sbjct: 90 VIKKA-KDDFSHDVIQNCLQYVYLGAGIFAAGMIQASCFLIICENLSNRFRREFFYSVMR 148
Query: 401 QEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLI 580
EIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQF+GGFAVAF+YDWLLTLI
Sbjct: 149 HEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFLGGFAVAFSYDWLLTLI 208
Query: 581 MMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRY 760
MMSLSPFMMICGLF QYAVAGGIAEEVLTSIRTVIAFNGQEYECKRY
Sbjct: 209 MMSLSPFMMICGLFLAKLLATAATKEAKQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRY 268
Query: 761 EDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFS 940
E+AL HG+KTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVY+GRL+SGTVLTVFFS
Sbjct: 269 EEALSHGRKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYNGRLDSGTVLTVFFS 328
Query: 941 VMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKV 1120
VMMGSMALGQAGQQFATIGTALGAAASLYEVIDR PEIDAYST+G TP KISGRI + +
Sbjct: 329 VMMGSMALGQAGQQFATIGTALGAAASLYEVIDRTPEIDAYSTKGVTPEKISGRIKIQNI 388
Query: 1121 EFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIP 1300
EFTYPTR DV+ILK VSL+AQPGQT+ALVGSSGCGKSTIIQLLQRFYNPDAG+I IDDI
Sbjct: 389 EFTYPTRPDVQILKDVSLEAQPGQTIALVGSSGCGKSTIIQLLQRFYNPDAGKIYIDDIA 448
Query: 1301 IEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFP 1480
IEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGR+DV + I RALKEANA DFIKTFP
Sbjct: 449 IEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRADVDSDAINRALKEANALDFIKTFP 508
Query: 1481 EGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENAS 1660
EGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESES+VQ+AL+NAS
Sbjct: 509 EGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESVVQAALDNAS 568
Query: 1661 RGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVDDK 1840
RGRTTIVIAHRLSTVRNADKIIVMKAG+VME+GTH+TLIEQKGLYHELVHAQVFADVD+K
Sbjct: 569 RGRTTIVIAHRLSTVRNADKIIVMKAGKVMEIGTHDTLIEQKGLYHELVHAQVFADVDEK 628
Query: 1841 PK-KKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXGA 2017
P+ KKEAERR+SRQTS RKGS+ KTQESQ + GA
Sbjct: 629 PRAKKEAERRLSRQTSARKGSL-IKTQESQAEEKSGPPPAPEPAEKEIKRLRKELEEEGA 687
Query: 2018 VKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGH 2197
VKANLFKIL+YARPEW+Y LIQGAVMPAFSLFFSQIINVFSNPDR+QMKKDGH
Sbjct: 688 VKANLFKILKYARPEWMYIFFAIIAALIQGAVMPAFSLFFSQIINVFSNPDREQMKKDGH 747
Query: 2198 FWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGR 2377
FWALMFLVLAA+QGTSMLFQC+ FGVAAE LTMR+RSKVYRNVLRQDATYFDMPKHSPGR
Sbjct: 748 FWALMFLVLAAIQGTSMLFQCAFFGVAAEGLTMRVRSKVYRNVLRQDATYFDMPKHSPGR 807
Query: 2378 ITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQA 2557
ITTRLATDAPNIKSAIDYRLGS+FNAIASVGGGLGIAFYYGWQMA LVMAIFPFMAVGQA
Sbjct: 808 ITTRLATDAPNIKSAIDYRLGSVFNAIASVGGGLGIAFYYGWQMALLVMAIFPFMAVGQA 867
Query: 2558 LMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNIS 2737
L++KYHGGSAT+DAKEMEN+GKTAMEAIENIRTVQALTLQTKLYNIFCSHLD+PH GN+S
Sbjct: 868 LVIKYHGGSATADAKEMENSGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDSPHSGNVS 927
Query: 2738 KAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFA 2917
KAIIRGLTYGFANSIQFFTYAAAFRFGLFLIF++NVLM PE+VL+VLFAISFSFGTIGFA
Sbjct: 928 KAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFNQNVLMSPEHVLKVLFAISFSFGTIGFA 987
Query: 2918 ASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVFFRYPERPAVPI 3097
ASYFPEYIKATFAAGLIFNMLEEEPRIDGMT++GT P LSGEVKLNKVFFRYPERPAVPI
Sbjct: 988 ASYFPEYIKATFAAGLIFNMLEEEPRIDGMTNAGTLPALSGEVKLNKVFFRYPERPAVPI 1047
Query: 3098 LQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKH 3277
LQGL+VHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVT+DNN+LRQMNPKHLRKH
Sbjct: 1048 LQGLDVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTIDNNNLRQMNPKHLRKH 1107
Query: 3278 IALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEK 3457
IALVSQEPILFDTSIRENI+YGLQPGEYT E I AC KANIHKFI ELPDGY+TRVGEK
Sbjct: 1108 IALVSQEPILFDTSIRENIIYGLQPGEYTEEAIAVACEKANIHKFISELPDGYQTRVGEK 1167
Query: 3458 GTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAH 3637
GTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQ+ALDAAAKDRTCIVVAH
Sbjct: 1168 GTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQIALDAAAKDRTCIVVAH 1227
Query: 3638 RLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSSNQSGGAFDTSEALXXX 3817
RLSTIVNAGCIMVVKNG+VVEQGTH EL+AKRGAYFALTQKQS NQ+GG FDT A+
Sbjct: 1228 RLSTIVNAGCIMVVKNGKVVEQGTHLELMAKRGAYFALTQKQSINQAGGEFDTGVAVEDD 1287
Query: 3818 XXXHVKF 3838
+VKF
Sbjct: 1288 DDDNVKF 1294
>gi|39587899|emb|CAE67917.1| Hypothetical protein CBG13514
[Caenorhabditis briggsae]
Length = 1319
Score = 1263 bits (3267), Expect = 0.0
Identities = 658/1263 (52%), Positives = 858/1263 (67%), Gaps = 18/1263 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
++I QLYRYT+ +++ML VG IV+ TG GLPLMSI+ G VSQ F+ + N T
Sbjct: 60 VTIPQLYRYTTMTEKIMLLVGTIVAIITGAGLPLMSILQGQVSQAFINEQIVINTGNHTI 119
Query: 221 SEKAA--ARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSV 394
++F+H+V+Q Y + G++AAG + +C++ + E+++NR RR+F ++
Sbjct: 120 PPNGRNYTDSDFNHDVMQVVWLYAGMTIGMWAAGQITVTCYLYVAEQMNNRLRREFVKAI 179
Query: 395 MRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLT 574
+RQ+I+W+D N SGTL+ KLFDNLERV+EGTGDK+G+AFQ M+QFI GF VAFT+ W LT
Sbjct: 180 LRQDISWFDTNHSGTLATKLFDNLERVKEGTGDKIGMAFQYMSQFITGFIVAFTHSWKLT 239
Query: 575 LIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECK 754
L+M++++P +CG +YA AG + EE ++SIRTV++ NG +E +
Sbjct: 240 LVMLAVTPIQALCGFLIAKSMSTFAIRETVRYAKAGKVVEETISSIRTVVSLNGLRHELE 299
Query: 755 RYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVF 934
RY A+E KK+G+ K +G + + S+ LAF++G +V+ G L G +LT F
Sbjct: 300 RYSTAVEEAKKSGVLKGLFLGISFGAMQATNFFSFALAFYIGVGWVHDGSLAPGDMLTTF 359
Query: 935 FSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVN 1114
SVMMGSMALG AG Q A +GTA GAA+S+YEV+DR P ID+ S+ G+ KI G I+V
Sbjct: 360 SSVMMGSMALGLAGPQLAVLGTAQGAASSIYEVLDRKPVIDSSSSAGRKDMKIKGDITVE 419
Query: 1115 KVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDD 1294
V FTYP+R DV IL+G++L GQTVALVGSSGCGKSTII LL R+Y+ G I ID
Sbjct: 420 NVHFTYPSRQDVPILRGMNLRVNAGQTVALVGSSGCGKSTIISLLLRYYDVLKGNITIDG 479
Query: 1295 IPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKT 1474
+ + D N+++LR V VVSQEP LFN +IE+NIR GR D++ E++ A K ANA FIKT
Sbjct: 480 VDVRDINLEFLRTNVAVVSQEPALFNCTIEENIRLGREDITREEMIAACKMANAEKFIKT 539
Query: 1475 FPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALEN 1654
P G NTLVGDRG Q+SGGQKQRIAIARALVRNPKILLLDEATSALDAESE IVQ AL+
Sbjct: 540 LPAGYNTLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAESEGIVQQALDK 599
Query: 1655 ASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVD 1834
A++GRTTI+IAHRLST+RNAD II K GQV+EVG H TL+ Q+GLY++LV AQ F D
Sbjct: 600 AAKGRTTIIIAHRLSTIRNADLIISCKNGQVVEVGDHRTLMAQEGLYYDLVTAQTFTDAV 659
Query: 1835 DKPK--KKEAERRMSRQTSQRKG-------------SVNFKTQESQVDXXXXXXXXXXXX 1969
D K E ++RQTS+ +G V T S +
Sbjct: 660 DASAGGKFSRENSIARQTSEHEGIFRQASELDDVLNRVRSSTMGSITNGPVIEEKEQRIG 719
Query: 1970 XXXXXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQII 2149
A + NLF+IL +A+P + ++ G + P +S+FF+ I
Sbjct: 720 KDALTRLKEELEENNAQRTNLFEILYHAKPHALSVAIGITAAIVGGFIYPTYSVFFTSFI 779
Query: 2150 NVFS-NPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNV 2326
NVFS NP D + GHFWALMFLVLAA QG G+A+E LTM +R+K++RNV
Sbjct: 780 NVFSGNP--DDILSQGHFWALMFLVLAAAQGICSFLMTFFMGIASESLTMDLRNKLFRNV 837
Query: 2327 LRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQ 2506
L Q +FD P+++ G+I TRLATD PN+++AID+R ++ + S+ G+G+AFYYGWQ
Sbjct: 838 LSQHIGFFDSPQNASGKICTRLATDVPNLRTAIDFRFSTVITTLVSMIAGIGLAFYYGWQ 897
Query: 2507 MAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKL 2686
MA L++AI P + GQ L + G+ A E ++GK A+EAIEN+RTVQAL +
Sbjct: 898 MALLIVAILPIVGFGQYLRGRRFTGNNVKSASEFADSGKIAIEAIENVRTVQALAREDTF 957
Query: 2687 YNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENV 2866
Y FCS LD PH I +A I+GL+YG A S+ + A+R GL LI + M P V
Sbjct: 958 YYKFCSKLDVPHKEAIKEAFIQGLSYGCACSVLYLLNTCAYRMGLALILHRT--MTPMRV 1015
Query: 2867 LRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEV 3046
LRV++AI+ S T+GFA SYFPEY KATFA G+IF ML+++ ID +T SG +LSG+V
Sbjct: 1016 LRVMYAITISTSTLGFATSYFPEYAKATFAGGIIFGMLKQKSEIDSLTLSGEKKKLSGKV 1075
Query: 3047 KLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVT 3226
V F YPERP + IL+GL+ V PGQTLALVGPSGCGKSTV++LLER YD L G V
Sbjct: 1076 IFKNVRFAYPERPQIEILKGLSFSVDPGQTLALVGPSGCGKSTVVALLERFYDTLAGEVF 1135
Query: 3227 VDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIH 3406
+D ++++ +NP++ R IA+VSQEP LFD SI ENIVYGL P T ++E A ANIH
Sbjct: 1136 IDGSEIKTLNPENTRSQIAIVSQEPTLFDCSIAENIVYGLDPTTVTMSRVEEAAKLANIH 1195
Query: 3407 KFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQ 3586
FI ELP+GYETRVG++GTQLSGGQKQRIAIARAL+RNPKILLLDEATSALDTESEK VQ
Sbjct: 1196 NFISELPEGYETRVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEKIVQ 1255
Query: 3587 VALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQS 3766
ALD A + RTCIV+AHRL+TI+NA CI VV NG ++EQGTH+ L++++GAY+ LTQKQ
Sbjct: 1256 EALDRAREGRTCIVIAHRLNTIMNADCIAVVNNGTIIEQGTHSVLMSQQGAYYKLTQKQM 1315
Query: 3767 SNQ 3775
S +
Sbjct: 1316 SEK 1318
Score = 369 bits (946), Expect = e-100
Identities = 230/630 (36%), Positives = 336/630 (52%), Gaps = 27/630 (4%)
Frame = +2
Query: 2021 KANLFKILRYAR-PEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSN----------- 2164
K + ++ RY E I +I GA +P S+ Q+ F N
Sbjct: 59 KVTIPQLYRYTTMTEKIMLLVGTIVAIITGAGLPLMSILQGQVSQAFINEQIVINTGNHT 118
Query: 2165 -PDRDQMKKDGHF--------WALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVY 2317
P + D F W + + + C L+ AE++ R+R +
Sbjct: 119 IPPNGRNYTDSDFNHDVMQVVWLYAGMTIGMWAAGQITVTCYLY--VAEQMNNRLRREFV 176
Query: 2318 RNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYY 2497
+ +LRQD ++FD HS G + T+L + +K ++G F ++ G +AF +
Sbjct: 177 KAILRQDISWFDT-NHS-GTLATKLFDNLERVKEGTGDKIGMAFQYMSQFITGFIVAFTH 234
Query: 2498 GWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQ 2677
W++ +++A+ P A+ L+ K A + AGK E I +IRTV +L
Sbjct: 235 SWKLTLVMLAVTPIQALCGFLIAKSMSTFAIRETVRYAKAGKVVEETISSIRTVVSLNGL 294
Query: 2678 TKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEP 2857
+ + ++ + K + G+++G + FF++A AF G+ + D + + P
Sbjct: 295 RHELERYSTAVEEAKKSGVLKGLFLGISFGAMQATNFFSFALAFYIGVGWVHDGS--LAP 352
Query: 2858 ENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYP-QL 3034
++L ++ +G A A AA I+ +L+ +P ID +S+G ++
Sbjct: 353 GDMLTTFSSVMMGSMALGLAGPQLAVLGTAQGAASSIYEVLDRKPVIDSSSSAGRKDMKI 412
Query: 3035 SGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLE 3214
G++ + V F YP R VPIL+G+N+ V GQT+ALVG SGCGKST+ISLL R YD L+
Sbjct: 413 KGDITVENVHFTYPSRQDVPILRGMNLRVNAGQTVALVGSSGCGKSTIISLLLRYYDVLK 472
Query: 3215 GAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSK 3394
G +T+D D+R +N + LR ++A+VSQEP LF+ +I ENI G + + T E++ AC
Sbjct: 473 GNITIDGVDVRDINLEFLRTNVAVVSQEPALFNCTIEENIRLGRE--DITREEMIAACKM 530
Query: 3395 ANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESE 3574
AN KFI LP GY T VG++GTQLSGGQKQRIAIARAL+RNPKILLLDEATSALD ESE
Sbjct: 531 ANAEKFIKTLPAGYNTLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAESE 590
Query: 3575 KQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALT 3754
VQ ALD AAK RT I++AHRLSTI NA I+ KNGQVVE G H L+A+ G Y+ L
Sbjct: 591 GIVQQALDKAAKGRTTIIIAHRLSTIRNADLIISCKNGQVVEVGDHRTLMAQEGLYYDLV 650
Query: 3755 QKQS-----SNQSGGAFDTSEALXXXXXXH 3829
Q+ +GG F ++ H
Sbjct: 651 TAQTFTDAVDASAGGKFSRENSIARQTSEH 680
>gi|17541710|ref|NP_502413.1| P-GlycoProtein related (pgp-1)
[Caenorhabditis elegans]
gi|29429182|sp|P34712|MDR1_CAEEL Multidrug resistance protein 1
(P-glycoprotein A)
gi|7505559|pir||T23476 hypothetical protein K08E7.9 - Caenorhabditis
elegans
gi|3878418|emb|CAB01232.1| Hypothetical protein K08E7.9
[Caenorhabditis elegans]
Length = 1321
Score = 1251 bits (3238), Expect = 0.0
Identities = 644/1265 (50%), Positives = 855/1265 (66%), Gaps = 20/1265 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNST- 217
+SI QLYRYT+T+++L+L +G +V+ TG GLPLMSI+ G VSQ F+ + + ST
Sbjct: 60 VSIPQLYRYTTTLEKLLLFIGTLVAVITGAGLPLMSILQGKVSQAFINEQIVINNNGSTF 119
Query: 218 -ASEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSV 394
+ + + +F H+V+ Y + G++AAG + +C++ + E+++NR RR+F S+
Sbjct: 120 LPTGQNYTKTDFEHDVMNVVWSYAAMTVGMWAAGQITVTCYLYVAEQMNNRLRREFVKSI 179
Query: 395 MRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLT 574
+RQEI+W+D N SGTL+ KLFDNLERV+EGTGDK+G+AFQ ++QFI GF VAFT+ W LT
Sbjct: 180 LRQEISWFDTNHSGTLATKLFDNLERVKEGTGDKIGMAFQYLSQFITGFIVAFTHSWQLT 239
Query: 575 LIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECK 754
L+M++++P +CG +YA AG + EE ++SIRTV++ NG YE +
Sbjct: 240 LVMLAVTPIQALCGFAIAKSMSTFAIRETLRYAKAGKVVEETISSIRTVVSLNGLRYELE 299
Query: 755 RYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVF 934
RY A+E KK G+ K +G + + S+ LAF++G +V+ G L G +LT F
Sbjct: 300 RYSTAVEEAKKAGVLKGLFLGISFGAMQASNFISFALAFYIGVGWVHDGSLNFGDMLTTF 359
Query: 935 FSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVN 1114
SVMMGSMALG AG Q A +GTA GAA+ +YEV+DR P ID+ S G+ KI G I+V
Sbjct: 360 SSVMMGSMALGLAGPQLAVLGTAQGAASGIYEVLDRKPVIDSSSKAGRKDMKIKGDITVE 419
Query: 1115 KVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDD 1294
V FTYP+R DV IL+G++L GQTVALVGSSGCGKSTII LL R+Y+ G+I ID
Sbjct: 420 NVHFTYPSRPDVPILRGMNLRVNAGQTVALVGSSGCGKSTIISLLLRYYDVLKGKITIDG 479
Query: 1295 IPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKT 1474
+ + D N+++LR+ V VVSQEP LFN +IE+NI G+ ++ E++ A K ANA FIKT
Sbjct: 480 VDVRDINLEFLRKNVAVVSQEPALFNCTIEENISLGKEGITREEMVAACKMANAEKFIKT 539
Query: 1475 FPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALEN 1654
P G NTLVGDRG Q+SGGQKQRIAIARALVRNPKILLLDEATSALDAESE IVQ AL+
Sbjct: 540 LPNGYNTLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAESEGIVQQALDK 599
Query: 1655 ASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVD 1834
A++GRTTI+IAHRLST+RNAD II K GQV+EVG H L+ Q+GLY++LV AQ F D
Sbjct: 600 AAKGRTTIIIAHRLSTIRNADLIISCKNGQVVEVGDHRALMAQQGLYYDLVTAQTFTDAV 659
Query: 1835 DKPK--KKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXX------------ 1972
D K E ++RQTS+ +G Q S++D
Sbjct: 660 DSAAEGKFSRENSVARQTSEHEG---LSRQASEMDDIMNRVRSSTIGSITNGPVIDEKEE 716
Query: 1973 ----XXXXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFS 2140
A K NLF+IL +ARP + I G + P +S+FF+
Sbjct: 717 RIGKDALSRLKQELEENNAQKTNLFEILYHARPHALSLFIGMSTATIGGFIYPTYSVFFT 776
Query: 2141 QIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYR 2320
+NVF+ D + + GHFWALMFLVLAA QG G+A+E LT +R+K++R
Sbjct: 777 SFMNVFAGNPADFLSQ-GHFWALMFLVLAAAQGICSFLMTFFMGIASESLTRDLRNKLFR 835
Query: 2321 NVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYG 2500
NVL Q +FD P+++ G+I+TRLATD PN+++AID+R ++ + S+ G+G+AF+YG
Sbjct: 836 NVLSQHIGFFDSPQNASGKISTRLATDVPNLRTAIDFRFSTVITTLVSMVAGIGLAFFYG 895
Query: 2501 WQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQT 2680
WQMA L++AI P +A GQ L + G A E ++GK A+EAIEN+RTVQAL +
Sbjct: 896 WQMALLIIAILPIVAFGQYLRGRRFTGKNVKSASEFADSGKIAIEAIENVRTVQALARED 955
Query: 2681 KLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPE 2860
Y FC LD PH I +A I+GL+YG A+S+ + A+R GL LI M+P
Sbjct: 956 TFYENFCEKLDIPHKEAIKEAFIQGLSYGCASSVLYLLNTCAYRMGLALIITDPPTMQPM 1015
Query: 2861 NVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSG 3040
VLRV++AI+ S T+GFA SYFPEY KATFA G+IF ML + +ID ++ +G +L G
Sbjct: 1016 RVLRVMYAITISTSTLGFATSYFPEYAKATFAGGIIFGMLRKISKIDSLSLAGEKKKLYG 1075
Query: 3041 EVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGA 3220
+V V F YPERP + IL+GL+ V+PGQTLALVGPSGCGKSTV++LLER YD L G
Sbjct: 1076 KVIFKNVRFAYPERPEIEILKGLSFSVEPGQTLALVGPSGCGKSTVVALLERFYDTLGGE 1135
Query: 3221 VTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKAN 3400
+ +D ++++ +NP+H R IA+VSQEP LFD SI ENI+YGL P T Q+E A AN
Sbjct: 1136 IFIDGSEIKTLNPEHTRSQIAIVSQEPTLFDCSIAENIIYGLDPSSVTMAQVEEAARLAN 1195
Query: 3401 IHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQ 3580
IH FI ELP+G+ETRVG++GTQLSGGQKQRIAIARAL+RNPKILLLDEATSALDTESEK
Sbjct: 1196 IHNFIAELPEGFETRVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEKV 1255
Query: 3581 VQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQK 3760
VQ ALD A + RTCIV+AHRL+T++NA CI VV NG ++E+GTH +L++++GAY+ LTQK
Sbjct: 1256 VQEALDRAREGRTCIVIAHRLNTVMNADCIAVVSNGTIIEKGTHTQLMSEKGAYYKLTQK 1315
Query: 3761 QSSNQ 3775
Q + +
Sbjct: 1316 QMTEK 1320
>gi|283551|pir||S27337 multidrug resistance protein A - Caenorhabditis
elegans
gi|6809|emb|CAA46190.1| P-glycoprotein A [Caenorhabditis elegans]
Length = 1321
Score = 1251 bits (3236), Expect = 0.0
Identities = 644/1265 (50%), Positives = 855/1265 (66%), Gaps = 20/1265 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNST- 217
+SI QLYRYT+T+++L+L +G +V+ TG GLPLMSI+ G VSQ F+ + + ST
Sbjct: 60 VSIPQLYRYTTTLEKLLLFIGTLVAVITGAGLPLMSILQGKVSQAFINEQIVINNNGSTF 119
Query: 218 -ASEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSV 394
+ + + +F H+V+ Y + G++AAG + +C++ + E+++NR RR+F S+
Sbjct: 120 LPTGQNYTKTDFEHDVMNVVWSYAAMTVGMWAAGQIIVTCYLYVAEQMNNRLRREFVKSI 179
Query: 395 MRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLT 574
+RQEI+W+D N SGTL+ KLFDNLERV+EGTGDK+G+AFQ ++QFI GF VAFT+ W LT
Sbjct: 180 LRQEISWFDTNHSGTLATKLFDNLERVKEGTGDKIGMAFQYLSQFITGFIVAFTHSWQLT 239
Query: 575 LIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECK 754
L+M++++P +CG +YA AG + EE ++SIRTV++ NG YE +
Sbjct: 240 LVMLAVTPIQALCGFAIAKSMSTFAIRETLRYAKAGKVVEETISSIRTVVSLNGLRYELE 299
Query: 755 RYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVF 934
RY A+E KK G+ K +G + + S+ LAF++G +V+ G L G +LT F
Sbjct: 300 RYSTAVEEAKKAGVLKGLFLGISFGAMQASNFISFALAFYIGVGWVHDGSLNFGDMLTTF 359
Query: 935 FSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVN 1114
SVMMGSMALG AG Q A +GTA GAA+ +YEV+DR P ID+ S G+ KI G I+V
Sbjct: 360 SSVMMGSMALGLAGPQLAVLGTAQGAASGIYEVLDRKPVIDSSSKAGRKDMKIKGDITVE 419
Query: 1115 KVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDD 1294
V FTYP+R DV IL+G++L GQTVALVGSSGCGKSTII LL R+Y+ G+I ID
Sbjct: 420 NVHFTYPSRPDVPILRGMNLRVNAGQTVALVGSSGCGKSTIISLLLRYYDVLKGKITIDG 479
Query: 1295 IPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKT 1474
+ + D N+++LR+ V VVSQEP LFN +IE+NI G+ ++ E++ A K ANA FIKT
Sbjct: 480 VDVRDINLEFLRKNVAVVSQEPALFNCTIEENISLGKEGITREEMVAACKMANAEKFIKT 539
Query: 1475 FPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALEN 1654
P G NTLVGDRG Q+SGGQKQRIAIARALVRNPKILLLDEATSALDAESE IVQ AL+
Sbjct: 540 LPNGYNTLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAESEGIVQQALDK 599
Query: 1655 ASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVD 1834
A++GRTTI+IAHRLST+RNAD II K GQV+EVG H L+ Q+GLY++LV AQ F D
Sbjct: 600 AAKGRTTIIIAHRLSTIRNADLIISCKNGQVVEVGDHRALMAQQGLYYDLVTAQTFTDAV 659
Query: 1835 DKPK--KKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXX------------ 1972
D K E ++RQTS+ +G Q S++D
Sbjct: 660 DSAAEGKFSRENSVARQTSEHEG---LSRQASEMDDIMNRVRSSTIGSITNGPVIDEKEE 716
Query: 1973 ----XXXXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFS 2140
A K NLF+IL +ARP + I G + P +S+FF+
Sbjct: 717 RIGKDALSRLKQELEENNAQKTNLFEILYHARPHALSLFIGMSTATIGGFIYPTYSVFFT 776
Query: 2141 QIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYR 2320
+NVF+ D + + GHFWALMFLVLAA QG G+A+E LT +R+K++R
Sbjct: 777 SFMNVFAGNPADFLSQ-GHFWALMFLVLAAAQGICSFLMTFFMGIASESLTRDLRNKLFR 835
Query: 2321 NVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYG 2500
NVL Q +FD P+++ G+I+TRLATD PN+++AID+R ++ + S+ G+G+AF+YG
Sbjct: 836 NVLSQHIGFFDSPQNASGKISTRLATDVPNLRTAIDFRFSTVITTLVSMVAGIGLAFFYG 895
Query: 2501 WQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQT 2680
WQMA L++AI P +A GQ L + G A E ++GK A+EAIEN+RTVQAL +
Sbjct: 896 WQMALLIIAILPIVAFGQYLRGRRFTGKNVKSASEFADSGKIAIEAIENVRTVQALARED 955
Query: 2681 KLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPE 2860
Y FC LD PH I +A I+GL+YG A+S+ + A+R GL LI M+P
Sbjct: 956 TFYENFCEKLDIPHKEAIKEAFIQGLSYGCASSVLYLLNTCAYRMGLALIITDPPTMQPM 1015
Query: 2861 NVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSG 3040
VLRV++AI+ S T+GFA SYFPEY KATFA G+IF ML + +ID ++ +G +L G
Sbjct: 1016 RVLRVMYAITISTSTLGFATSYFPEYAKATFAGGIIFGMLRKISKIDSLSLAGEKKKLYG 1075
Query: 3041 EVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGA 3220
+V V F YPERP + IL+GL+ V+PGQTLALVGPSGCGKSTV++LLER YD L G
Sbjct: 1076 KVIFKNVRFAYPERPEIEILKGLSFSVEPGQTLALVGPSGCGKSTVVALLERFYDTLGGE 1135
Query: 3221 VTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKAN 3400
+ +D ++++ +NP+H R IA+VSQEP LFD SI ENI+YGL P T Q+E A AN
Sbjct: 1136 IFIDGSEIKTLNPEHTRSQIAIVSQEPTLFDCSIAENIIYGLDPSSVTMAQVEEAARLAN 1195
Query: 3401 IHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQ 3580
IH FI ELP+G+ETRVG++GTQLSGGQKQRIAIARAL+RNPKILLLDEATSALDTESEK
Sbjct: 1196 IHNFIAELPEGFETRVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEKV 1255
Query: 3581 VQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQK 3760
VQ ALD A + RTCIV+AHRL+T++NA CI VV NG ++E+GTH +L++++GAY+ LTQK
Sbjct: 1256 VQEALDRAREGRTCIVIAHRLNTVMNADCIAVVSNGTIIEKGTHTQLMSEKGAYYKLTQK 1315
Query: 3761 QSSNQ 3775
Q + +
Sbjct: 1316 QMTEK 1320
>gi|126924|sp|P21448|MDR1_CRIGR Multidrug resistance protein 1
(P-glycoprotein 1)
gi|191165|gb|AAA68883.1| p-glycoprotein isoform I
Length = 1276
Score = 1091 bits (2822), Expect = 0.0
Identities = 569/1247 (45%), Positives = 795/1247 (63%), Gaps = 5/1247 (0%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+S+F ++RY +DRL + VG + + GV LPLM ++ G+++ +F ++G I + + A
Sbjct: 33 VSVFTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLVFGDMTDSFASVGNIPTNATNNA 92
Query: 221 SEKAAAR--AEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSV 394
++ A+ + E+ Y +G G+ ++Q S + + + ++ R++FFH++
Sbjct: 93 TQVNASDIFGKLEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFHAI 152
Query: 395 MRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLT 574
M QEI W+D + G L+ +L D++ ++ EG GDK+G+ FQ MA F GGF + FT W LT
Sbjct: 153 MNQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLT 212
Query: 575 LIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECK 754
L+++++SP + + YA AG +AEEVL +IRTVIAF GQ+ E +
Sbjct: 213 LVILAISPVLGLSAGIWAKILSSFTDKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKELE 272
Query: 755 RYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVF 934
RY + LE K+ GIKK+ + + F++IYASY LAFW GT+ V S G VLTVF
Sbjct: 273 RYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYSIGQVLTVF 332
Query: 935 FSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVN 1114
F+V++G+ ++GQA A GAA ++ +ID P ID++S G P I G +
Sbjct: 333 FAVLIGAFSIGQASPNIEAFANARGAAYEIFNIIDNKPSIDSFSKNGYKPDNIKGNLEFK 392
Query: 1115 KVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDD 1294
+ F+YP+R DV+ILKG++L Q GQTVALVG+SGCGKST +QLLQR Y+P G + ID
Sbjct: 393 NIHFSYPSRKDVQILKGLNLKVQSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGVVSIDG 452
Query: 1295 IPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKT 1474
I N++YLR+++GVVSQEP LF T+I +NIRYGR +V+ ++I +A+KEANA DFI
Sbjct: 453 QDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMK 512
Query: 1475 FPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALEN 1654
P +TLVG+RG Q+SGGQKQRIAIARALVRNPKILLLDEATSALD ESE++VQ+AL+
Sbjct: 513 LPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDK 572
Query: 1655 ASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFA-DV 1831
A GRTTIVIAHRLSTVRNAD I G ++E G HE L+ +KG+Y +LV Q ++
Sbjct: 573 AREGRTTIVIAHRLSTVRNADIIAGFDGGVIVEQGNHEELMREKGIYFKLVMTQTAGNEI 632
Query: 1832 DDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXX 2011
+ + E++ + K S + S +
Sbjct: 633 ELGNEVGESKNEIDNLDMSSKDSAS-----SLIRRRSTRRSIRGPHDQDRKLSTKEALDE 687
Query: 2012 GAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFS-NPDRDQMKK 2188
+ ++IL+ EW Y ++ GA+ PAFS+ FS+++ VF+ N D + +
Sbjct: 688 DVPPISFWRILKLNSSEWPYFVVGIFCAIVNGALQPAFSIIFSKVVGVFTRNTDDETKRH 747
Query: 2189 DGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHS 2368
D + ++L+FL+L + + Q FG A E LT R+R V++++LRQD ++FD PK++
Sbjct: 748 DSNLFSLLFLILGVISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDNPKNT 807
Query: 2369 PGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAV 2548
G +TTRLA DA +K A RL I IA++G G+ I+ YGWQ+ L++AI P +A+
Sbjct: 808 TGALTTRLANDAGQVKGATGARLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAI 867
Query: 2549 GQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGG 2728
+ MK G A D KE+E +GK A EAIEN RTV +LT + K N++ L P+
Sbjct: 868 AGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFENMYAQSLQIPYRN 927
Query: 2729 NISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTI 2908
+ KA + G+T+ F ++ +F+YAA FRFG +L+ LM ENVL V AI F +
Sbjct: 928 ALKKAHVFGITFSFTQAMMYFSYAACFRFGAYLV--ARELMTFENVLLVFSAIVFGAMAV 985
Query: 2909 GFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKLNKVFFRYPERP 3085
G +S+ P+Y KA +A I ++E+ P ID ++ G P L G VK N+V F YP RP
Sbjct: 986 GQVSSFAPDYAKAKVSASHIIMIIEKVPSIDSYSTGGLKPNTLEGNVKFNEVVFNYPTRP 1045
Query: 3086 AVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKH 3265
+P+LQGLN+ VK GQTLALVG SGCGKSTV+ LLER YDP+ G V +D ++ Q+N +
Sbjct: 1046 DIPVLQGLNLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEVNQLNVQW 1105
Query: 3266 LRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETR 3445
LR H+ +VSQEPILFD SI ENI YG + ++IE A +ANIH+FI+ LPD Y TR
Sbjct: 1106 LRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIERAAKEANIHQFIESLPDKYNTR 1165
Query: 3446 VGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCI 3625
VG+KGTQLSGGQKQRIAIARAL+R P ILLLDEATSALDTESEK VQ ALD A + RTCI
Sbjct: 1166 VGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCI 1225
Query: 3626 VVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQS 3766
V+AHRLSTI NA I+V++NG+V E GTH +L+A++G YF++ Q+
Sbjct: 1226 VIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQA 1272
Score = 408 bits (1049), Expect = e-112
Identities = 231/580 (39%), Positives = 339/580 (57%), Gaps = 4/580 (0%)
Frame = +2
Query: 98 VGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHEVIQNCL 277
VGI + G P SII V F N+ K FS L
Sbjct: 710 VGIFCAIVNGALQPAFSIIFSKVVGVFTR--------NTDDETKRHDSNLFS-------L 754
Query: 278 KYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYD--KNTSGTLSNK 451
++ LG F FLQ F E L+ R R F S++RQ+++W+D KNT+G L+ +
Sbjct: 755 LFLILGVISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDNPKNTTGALTTR 814
Query: 452 LFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXXX 631
L ++ +V+ TG ++ + Q +A G ++ Y W LTL+++++ P + I G+
Sbjct: 815 LANDAGQVKGATGARLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMK 874
Query: 632 XXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFL 811
+ +G IA E + + RTV++ ++ Y +L+ + +KK+ +
Sbjct: 875 MLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFENMYAQSLQIPYRNALKKAHV 934
Query: 812 IGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQFAT 991
G + ++Y SY F G V + VL VF +++ G+MA+GQ
Sbjct: 935 FGITFSFTQAMMYFSYAACFRFGAYLVARELMTFENVLLVFSAIVFGAMAVGQVSSFAPD 994
Query: 992 IGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKGVS 1171
A +A+ + +I+++P ID+YST G P+ + G + N+V F YPTR D+ +L+G++
Sbjct: 995 YAKAKVSASHIIMIIEKVPSIDSYSTGGLKPNTLEGNVKFNEVVFNYPTRPDIPVLQGLN 1054
Query: 1172 LDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVS 1351
L+ + GQT+ALVGSSGCGKST++QLL+RFY+P AG + +D + N+++LR +G+VS
Sbjct: 1055 LEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEVNQLNVQWLRAHLGIVS 1114
Query: 1352 QEPNLFNTSIEQNIRYGRSD--VSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQMS 1525
QEP LF+ SI +NI YG + VS ++I RA KEAN FI++ P+ NT VGD+G Q+S
Sbjct: 1115 QEPILFDCSIAENIAYGDNSRVVSQDEIERAAKEANIHQFIESLPDKYNTRVGDKGTQLS 1174
Query: 1526 GGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLSTV 1705
GGQKQRIAIARALVR P ILLLDEATSALD ESE +VQ AL+ A GRT IVIAHRLST+
Sbjct: 1175 GGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTI 1234
Query: 1706 RNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFA 1825
+NAD I+V++ G+V E GTH+ L+ QKG+Y +V Q A
Sbjct: 1235 QNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQAGA 1274
Score = 382 bits (982), Expect = e-104
Identities = 231/603 (38%), Positives = 335/603 (55%), Gaps = 22/603 (3%)
Frame = +2
Query: 2027 NLFKILRYARPEWI---YXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDR-------- 2173
++F + RYA W+ Y +I G +P L F + + F++
Sbjct: 34 SVFTMFRYAG--WLDRLYMLVGTLAAIIHGVALPLMMLVFGDMTDSFASVGNIPTNATNN 91
Query: 2174 ----------DQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRN 2323
+++++ +A + + A Q S + +AA R +IR K +
Sbjct: 92 ATQVNASDIFGKLEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFHA 151
Query: 2324 VLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGW 2503
++ Q+ +FD+ H G + TRL D I I ++G F A+A+ GG I F GW
Sbjct: 152 IMNQEIGWFDV--HDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGW 209
Query: 2504 QMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTK 2683
++ +++AI P + + + K + + AG A E + IRTV A Q K
Sbjct: 210 KLTLVILAISPVLGLSAGIWAKILSSFTDKELQAYAKAGAVAEEVLAAIRTVIAFGGQKK 269
Query: 2684 LYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPEN 2863
+ ++L+ I KAI ++ G A + + +YA AF +G L+ K +
Sbjct: 270 ELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYSIG--Q 327
Query: 2864 VLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSG 3040
VL V FA+ +IG A+ + A AA IFN+++ +P ID + +G P + G
Sbjct: 328 VLTVFFAVLIGAFSIGQASPNIEAFANARGAAYEIFNIIDNKPSIDSFSKNGYKPDNIKG 387
Query: 3041 EVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGA 3220
++ + F YP R V IL+GLN+ V+ GQT+ALVG SGCGKST + LL+RLYDP EG
Sbjct: 388 NLEFKNIHFSYPSRKDVQILKGLNLKVQSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGV 447
Query: 3221 VTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKAN 3400
V++D D+R +N ++LR+ I +VSQEP+LF T+I ENI YG + T ++IE A +AN
Sbjct: 448 VSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRE--NVTMDEIEKAVKEAN 505
Query: 3401 IHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQ 3580
+ FI +LP ++T VGE+G QLSGGQKQRIAIARAL+RNPKILLLDEATSALDTESE
Sbjct: 506 AYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAV 565
Query: 3581 VQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQK 3760
VQ ALD A + RT IV+AHRLST+ NA I G +VEQG H EL+ ++G YF L
Sbjct: 566 VQAALDKAREGRTTIVIAHRLSTVRNADIIAGFDGGVIVEQGNHEELMREKGIYFKLVMT 625
Query: 3761 QSS 3769
Q++
Sbjct: 626 QTA 628
>gi|72477|pir||DVHY1C multidrug resistance protein 1 - Chinese hamster
gi|191155|gb|AAA37004.1| p-glycoprotein
Length = 1276
Score = 1088 bits (2814), Expect = 0.0
Identities = 568/1247 (45%), Positives = 793/1247 (63%), Gaps = 5/1247 (0%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+S+F ++RY +DRL + VG + + GV LPLM ++ G+++ +F ++G I + + A
Sbjct: 33 VSVFTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLVFGDMTDSFASVGNIPTNATNNA 92
Query: 221 SEKAAAR--AEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSV 394
++ A+ + E+ Y +G G+ ++Q S + + + ++ R++FFH++
Sbjct: 93 TQVNASDIFGKLEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFHAI 152
Query: 395 MRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLT 574
M QEI W+D + G L+ +L D++ ++ EG GDK+G+ FQ MA F GGF + FT W LT
Sbjct: 153 MNQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLT 212
Query: 575 LIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECK 754
L+++++SP + + YA AG +AEEVL +IRTVIAF GQ+ E +
Sbjct: 213 LVILAISPVLGLSAGIWAKILSSFTDKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKELE 272
Query: 755 RYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVF 934
RY + LE K+ GIKK+ + + F++IYASY LAFW GT+ V S G VLTVF
Sbjct: 273 RYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYSIGQVLTVF 332
Query: 935 FSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVN 1114
F+V++ ++GQA A GAA ++ +ID P ID++S G P I G +
Sbjct: 333 FAVLIAPFSIGQASPNIEAFANARGAAYEIFNIIDNKPSIDSFSKNGYKPDNIKGNLEFK 392
Query: 1115 KVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDD 1294
+ F+YP+R DV+ILKG++L Q GQTVALVG+SGCGKST +QLLQR Y+P G + ID
Sbjct: 393 NIHFSYPSRKDVQILKGLNLKVQSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGVVSIDG 452
Query: 1295 IPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKT 1474
I N++YLR+++GVVSQEP LF T+I +NIRYGR +V+ ++I +A+KEANA DFI
Sbjct: 453 QDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMK 512
Query: 1475 FPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALEN 1654
P +TLVG+RG Q+SGGQKQRIAIARALVRNPKILLLDEATSALD ESE++VQ+AL+
Sbjct: 513 LPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDK 572
Query: 1655 ASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFA-DV 1831
A GRTTIVIAHRLSTVRNAD I G ++E G HE L+ +KG+Y +LV Q ++
Sbjct: 573 AREGRTTIVIAHRLSTVRNADIIAGFDGGVIVEQGNHEELMREKGIYFKLVMTQTAGNEI 632
Query: 1832 DDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXX 2011
+ + E++ + K S + S +
Sbjct: 633 ELGNEVGESKNEIDNLDMSSKDSAS-----SLIRRRSTRRSIRGPHDQDRKLSTKEALDE 687
Query: 2012 GAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFS-NPDRDQMKK 2188
+ ++IL+ EW Y ++ GA+ PAFS+ FS+++ VF+ N D + +
Sbjct: 688 DVPPISFWRILKLNSSEWPYFVVGIFCAIVNGALQPAFSIIFSKVVGVFTRNTDDETKRH 747
Query: 2189 DGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHS 2368
D + ++L+FL+L + + Q FG A E LT R+R V++++LRQD ++FD PK++
Sbjct: 748 DSNLFSLLFLILGVISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDNPKNT 807
Query: 2369 PGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAV 2548
G +TTRLA DA +K A RL I IA++G G+ I+ YGWQ+ L++AI P +A+
Sbjct: 808 TGALTTRLANDAGQVKGATGARLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAI 867
Query: 2549 GQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGG 2728
+ MK G A D KE+E +GK A EAIEN RTV +LT + K N++ L P+
Sbjct: 868 AGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFENMYAQSLQIPYRN 927
Query: 2729 NISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTI 2908
+ KA + G+T+ F ++ +F+YAA FRFG +L+ LM ENVL V AI F +
Sbjct: 928 ALKKAHVFGITFSFTQAMMYFSYAACFRFGAYLV--ARELMTFENVLLVFSAIVFGAMAV 985
Query: 2909 GFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKLNKVFFRYPERP 3085
G +S+ P+Y KA +A I ++E+ P ID ++ G P L G VK N+V F YP RP
Sbjct: 986 GQVSSFAPDYAKAKVSASHIIMIIEKVPSIDSYSTGGLKPNTLEGNVKFNEVVFNYPTRP 1045
Query: 3086 AVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKH 3265
+P+LQGLN+ VK GQTLALVG SGCGKSTV+ LLER YDP+ G V +D ++ Q+N +
Sbjct: 1046 DIPVLQGLNLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEVNQLNVQW 1105
Query: 3266 LRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETR 3445
LR H+ +VSQEPILFD SI ENI YG + ++IE A +ANIH+FI+ LPD Y TR
Sbjct: 1106 LRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIERAAKEANIHQFIESLPDKYNTR 1165
Query: 3446 VGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCI 3625
VG+KGTQLSGGQKQRIAIARAL+R P ILLLDEATSALDTESEK VQ ALD A + RTCI
Sbjct: 1166 VGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCI 1225
Query: 3626 VVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQS 3766
V+AHRLSTI NA I+V++NG+V E GTH +L+A++G YF++ Q+
Sbjct: 1226 VIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQA 1272
Score = 408 bits (1049), Expect = e-112
Identities = 231/580 (39%), Positives = 339/580 (57%), Gaps = 4/580 (0%)
Frame = +2
Query: 98 VGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHEVIQNCL 277
VGI + G P SII V F N+ K FS L
Sbjct: 710 VGIFCAIVNGALQPAFSIIFSKVVGVFTR--------NTDDETKRHDSNLFS-------L 754
Query: 278 KYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYD--KNTSGTLSNK 451
++ LG F FLQ F E L+ R R F S++RQ+++W+D KNT+G L+ +
Sbjct: 755 LFLILGVISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDNPKNTTGALTTR 814
Query: 452 LFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXXX 631
L ++ +V+ TG ++ + Q +A G ++ Y W LTL+++++ P + I G+
Sbjct: 815 LANDAGQVKGATGARLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMK 874
Query: 632 XXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFL 811
+ +G IA E + + RTV++ ++ Y +L+ + +KK+ +
Sbjct: 875 MLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFENMYAQSLQIPYRNALKKAHV 934
Query: 812 IGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQFAT 991
G + ++Y SY F G V + VL VF +++ G+MA+GQ
Sbjct: 935 FGITFSFTQAMMYFSYAACFRFGAYLVARELMTFENVLLVFSAIVFGAMAVGQVSSFAPD 994
Query: 992 IGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKGVS 1171
A +A+ + +I+++P ID+YST G P+ + G + N+V F YPTR D+ +L+G++
Sbjct: 995 YAKAKVSASHIIMIIEKVPSIDSYSTGGLKPNTLEGNVKFNEVVFNYPTRPDIPVLQGLN 1054
Query: 1172 LDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVS 1351
L+ + GQT+ALVGSSGCGKST++QLL+RFY+P AG + +D + N+++LR +G+VS
Sbjct: 1055 LEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEVNQLNVQWLRAHLGIVS 1114
Query: 1352 QEPNLFNTSIEQNIRYGRSD--VSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQMS 1525
QEP LF+ SI +NI YG + VS ++I RA KEAN FI++ P+ NT VGD+G Q+S
Sbjct: 1115 QEPILFDCSIAENIAYGDNSRVVSQDEIERAAKEANIHQFIESLPDKYNTRVGDKGTQLS 1174
Query: 1526 GGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLSTV 1705
GGQKQRIAIARALVR P ILLLDEATSALD ESE +VQ AL+ A GRT IVIAHRLST+
Sbjct: 1175 GGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTI 1234
Query: 1706 RNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFA 1825
+NAD I+V++ G+V E GTH+ L+ QKG+Y +V Q A
Sbjct: 1235 QNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQAGA 1274
Score = 382 bits (981), Expect = e-104
Identities = 231/603 (38%), Positives = 336/603 (55%), Gaps = 22/603 (3%)
Frame = +2
Query: 2027 NLFKILRYARPEWI---YXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDR-------- 2173
++F + RYA W+ Y +I G +P L F + + F++
Sbjct: 34 SVFTMFRYAG--WLDRLYMLVGTLAAIIHGVALPLMMLVFGDMTDSFASVGNIPTNATNN 91
Query: 2174 ----------DQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRN 2323
+++++ +A + + A Q S + +AA R +IR K +
Sbjct: 92 ATQVNASDIFGKLEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFHA 151
Query: 2324 VLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGW 2503
++ Q+ +FD+ H G + TRL D I I ++G F A+A+ GG I F GW
Sbjct: 152 IMNQEIGWFDV--HDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGW 209
Query: 2504 QMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTK 2683
++ +++AI P + + + K + + AG A E + IRTV A Q K
Sbjct: 210 KLTLVILAISPVLGLSAGIWAKILSSFTDKELQAYAKAGAVAEEVLAAIRTVIAFGGQKK 269
Query: 2684 LYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPEN 2863
+ ++L+ I KAI ++ G A + + +YA AF +G L+ K +
Sbjct: 270 ELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYSIG--Q 327
Query: 2864 VLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSG 3040
VL V FA+ + +IG A+ + A AA IFN+++ +P ID + +G P + G
Sbjct: 328 VLTVFFAVLIAPFSIGQASPNIEAFANARGAAYEIFNIIDNKPSIDSFSKNGYKPDNIKG 387
Query: 3041 EVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGA 3220
++ + F YP R V IL+GLN+ V+ GQT+ALVG SGCGKST + LL+RLYDP EG
Sbjct: 388 NLEFKNIHFSYPSRKDVQILKGLNLKVQSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGV 447
Query: 3221 VTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKAN 3400
V++D D+R +N ++LR+ I +VSQEP+LF T+I ENI YG + T ++IE A +AN
Sbjct: 448 VSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRE--NVTMDEIEKAVKEAN 505
Query: 3401 IHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQ 3580
+ FI +LP ++T VGE+G QLSGGQKQRIAIARAL+RNPKILLLDEATSALDTESE
Sbjct: 506 AYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAV 565
Query: 3581 VQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQK 3760
VQ ALD A + RT IV+AHRLST+ NA I G +VEQG H EL+ ++G YF L
Sbjct: 566 VQAALDKAREGRTTIVIAHRLSTVRNADIIAGFDGGVIVEQGNHEELMREKGIYFKLVMT 625
Query: 3761 QSS 3769
Q++
Sbjct: 626 QTA 628
>gi|6755048|ref|NP_035206.1| ATP-binding cassette, sub-family B
(MDR/TAP), member 1A; P glycoprotein 3; ATP-binding
cassette, sub-family B (MDR/TAP), member 4; multi-drug
resistance 3; P-glycoprotein; multiple drug resistant 1a
[Mus musculus]
gi|387427|gb|AAA39514.1| P-glycoprotein
Length = 1276
Score = 1083 bits (2802), Expect = 0.0
Identities = 568/1249 (45%), Positives = 800/1249 (63%), Gaps = 7/1249 (0%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDP-NST 217
+S+ ++RY +DRL + VG + + GV LPLM +I G+++ +F ++G + + N +
Sbjct: 33 VSVLTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLIFGDMTDSFASVGNVSKNSTNMS 92
Query: 218 ASEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVM 397
++K A A+ E+ Y +G G+ ++Q S + + + ++ R++FFH++M
Sbjct: 93 EADKRAMFAKLEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFHAIM 152
Query: 398 RQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
QEI W+D + G L+ +L D++ ++ EG GDK+G+ FQ MA F GGF + FT W LTL
Sbjct: 153 NQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTL 212
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
+++++SP + + YA AG +AEEVL +IRTVIAF GQ+ E +R
Sbjct: 213 VILAISPVLGLSAGIWAKILSSFTDKELHAYAKAGAVAEEVLAAIRTVIAFGGQKKELER 272
Query: 758 YEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFF 937
Y + LE K+ GIKK+ + + F++IYASY LAFW GT+ V S G VLTVFF
Sbjct: 273 YNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYSIGQVLTVFF 332
Query: 938 SVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNK 1117
SV++G+ ++GQA A GAA ++++ID P ID++S G P I G +
Sbjct: 333 SVLIGAFSVGQASPNIEAFANARGAAYEVFKIIDNKPSIDSFSKSGHKPDNIQGNLEFKN 392
Query: 1118 VEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDI 1297
+ F+YP+R +V+ILKG++L + GQTVALVG+SGCGKST +QL+QR Y+P G + ID
Sbjct: 393 IHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQ 452
Query: 1298 PIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTF 1477
I N++YLR+++GVVSQEP LF T+I +NIRYGR DV+ ++I +A+KEANA DFI
Sbjct: 453 DIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKL 512
Query: 1478 PEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENA 1657
P +TLVG+RG +SGGQKQRIAIARALVRNPKILLLDEATSALD ESE++VQ+AL+ A
Sbjct: 513 PHQFDTLVGERGAHVSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKA 572
Query: 1658 SRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFA---D 1828
GRTTIVIAHRLSTVRNAD I G ++E G H+ L+ +KG+Y +LV Q +
Sbjct: 573 REGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTAGNEIE 632
Query: 1829 VDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXX 2008
+ ++ K + E +S+ GS S +
Sbjct: 633 LGNEACKSKDEIDNLDMSSKDSGS-------SLIRRRSTRKSICGPHDQDRKLSTKEALD 685
Query: 2009 XGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSN--PDRDQM 2182
A+ ++IL+ EW Y +I G + PAFS+ FS+++ VF+N P Q
Sbjct: 686 EDVPPASFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFSKVVGVFTNGGPPETQ- 744
Query: 2183 KKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPK 2362
+++ + ++L+FL+L + + Q FG A E LT R+R V++++LRQD ++FD PK
Sbjct: 745 RQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPK 804
Query: 2363 HSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFM 2542
++ G +TTRLA DA +K A RL IF IA++G G+ I+ YGWQ+ L++AI P +
Sbjct: 805 NTTGALTTRLANDAAQVKGATGSRLAVIFQNIANLGTGIIISLIYGWQLTLLLLAIVPII 864
Query: 2543 AVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPH 2722
A+ + MK G A D KE+E +GK A EAIEN RTV +LT + K ++ L P+
Sbjct: 865 AIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPY 924
Query: 2723 GGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFG 2902
+ KA + G+T+ F ++ +F+YAA FRFG +L+ + LM ENVL V AI F
Sbjct: 925 RNAMKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVTQQ--LMTFENVLLVFSAIVFGAM 982
Query: 2903 TIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYP-QLSGEVKLNKVFFRYPE 3079
+G +S+ P+Y KAT +A I ++E+ P ID ++ G P L G V+ + V F YP
Sbjct: 983 AVGQVSSFAPDYAKATVSASHIIRIIEKTPEIDSYSTQGLKPNMLEGNVQFSGVVFNYPT 1042
Query: 3080 RPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNP 3259
RP++P+LQGL++ VK GQTLALVG SGCGKSTV+ LLER YDP+ G+V +D +++Q+N
Sbjct: 1043 RPSIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNV 1102
Query: 3260 KHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYE 3439
+ LR + +VSQEPILFD SI ENI YG ++E+I A +ANIH+FID LPD Y
Sbjct: 1103 QWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSYEEIVRAAKEANIHQFIDSLPDKYN 1162
Query: 3440 TRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRT 3619
TRVG+KGTQLSGGQKQRIAIARAL+R P ILLLDEATSALDTESEK VQ ALD A + RT
Sbjct: 1163 TRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRT 1222
Query: 3620 CIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQS 3766
CIV+AHRLSTI NA I+V++NG+V E GTH +L+A++G YF++ Q+
Sbjct: 1223 CIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQA 1271
Score = 411 bits (1057), Expect = e-113
Identities = 234/580 (40%), Positives = 341/580 (58%), Gaps = 4/580 (0%)
Frame = +2
Query: 98 VGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHEVIQNCL 277
VGI + G P S+I V F G P T + + FS L
Sbjct: 709 VGIFCAIINGGLQPAFSVIFSKVVGVFTNGG-----PPETQRQNSNL---FS-------L 753
Query: 278 KYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYD--KNTSGTLSNK 451
++ LG F FLQ F E L+ R R F S++RQ+++W+D KNT+G L+ +
Sbjct: 754 LFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTR 813
Query: 452 LFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXXX 631
L ++ +V+ TG ++ + FQ +A G ++ Y W LTL+++++ P + I G+
Sbjct: 814 LANDAAQVKGATGSRLAVIFQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMK 873
Query: 632 XXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFL 811
+ +G IA E + + RTV++ ++ Y +L+ + +KK+ +
Sbjct: 874 MLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNAMKKAHV 933
Query: 812 IGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQFAT 991
G + ++Y SY F G V + VL VF +++ G+MA+GQ
Sbjct: 934 FGITFSFTQAMMYFSYAACFRFGAYLVTQQLMTFENVLLVFSAIVFGAMAVGQVSSFAPD 993
Query: 992 IGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKGVS 1171
A +A+ + +I++ PEID+YST+G P+ + G + + V F YPTR + +L+G+S
Sbjct: 994 YAKATVSASHIIRIIEKTPEIDSYSTQGLKPNMLEGNVQFSGVVFNYPTRPSIPVLQGLS 1053
Query: 1172 LDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVS 1351
L+ + GQT+ALVGSSGCGKST++QLL+RFY+P AG + +D I+ N+++LR +G+VS
Sbjct: 1054 LEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAQLGIVS 1113
Query: 1352 QEPNLFNTSIEQNIRYGRSD--VSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQMS 1525
QEP LF+ SI +NI YG + VS E+I RA KEAN FI + P+ NT VGD+G Q+S
Sbjct: 1114 QEPILFDCSIAENIAYGDNSRVVSYEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLS 1173
Query: 1526 GGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLSTV 1705
GGQKQRIAIARALVR P ILLLDEATSALD ESE +VQ AL+ A GRT IVIAHRLST+
Sbjct: 1174 GGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTI 1233
Query: 1706 RNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFA 1825
+NAD I+V++ G+V E GTH+ L+ QKG+Y +V Q A
Sbjct: 1234 QNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQAGA 1273
Score = 377 bits (968), Expect = e-102
Identities = 224/586 (38%), Positives = 327/586 (55%), Gaps = 18/586 (3%)
Frame = +2
Query: 2066 IYXXXXXXXXLIQGAVMPAFSLFFSQIINVF-------------SNPDRDQM----KKDG 2194
+Y +I G +P L F + + F S D+ M +++
Sbjct: 48 LYMLVGTLAAIIHGVALPLMMLIFGDMTDSFASVGNVSKNSTNMSEADKRAMFAKLEEEM 107
Query: 2195 HFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPG 2374
+A + + A Q S + +AA R +IR K + ++ Q+ +FD+ H G
Sbjct: 108 TTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFHAIMNQEIGWFDV--HDVG 165
Query: 2375 RITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQ 2554
+ TRL D I I ++G F A+A+ GG I F GW++ +++AI P + +
Sbjct: 166 ELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTLVILAISPVLGLSA 225
Query: 2555 ALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNI 2734
+ K + AG A E + IRTV A Q K + ++L+ I
Sbjct: 226 GIWAKILSSFTDKELHAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEAKRLGI 285
Query: 2735 SKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGF 2914
KAI ++ G A + + +YA AF +G L+ K + VL V F++ ++G
Sbjct: 286 KKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYSIG--QVLTVFFSVLIGAFSVGQ 343
Query: 2915 AASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKLNKVFFRYPERPAV 3091
A+ + A AA +F +++ +P ID + SG P + G ++ + F YP R V
Sbjct: 344 ASPNIEAFANARGAAYEVFKIIDNKPSIDSFSKSGHKPDNIQGNLEFKNIHFSYPSRKEV 403
Query: 3092 PILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLR 3271
IL+GLN+ VK GQT+ALVG SGCGKST + L++RLYDPL+G V++D D+R +N ++LR
Sbjct: 404 QILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRYLR 463
Query: 3272 KHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVG 3451
+ I +VSQEP+LF T+I ENI YG + + T ++IE A +AN + FI +LP ++T VG
Sbjct: 464 EIIGVVSQEPVLFATTIAENIRYGRE--DVTMDEIEKAVKEANAYDFIMKLPHQFDTLVG 521
Query: 3452 EKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVV 3631
E+G +SGGQKQRIAIARAL+RNPKILLLDEATSALDTESE VQ ALD A + RT IV+
Sbjct: 522 ERGAHVSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVI 581
Query: 3632 AHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSS 3769
AHRLST+ NA I G +VEQG H+EL+ ++G YF L Q++
Sbjct: 582 AHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTA 627
>gi|266517|sp|P21447|MDR3_MOUSE Multidrug resistance protein 3
(P-glycoprotein 3) (MDR1A)
gi|110720|pir||A34786 multidrug resistance protein 1a - mouse
gi|387429|gb|AAA39517.1| multidrug resistance protein
Length = 1276
Score = 1083 bits (2800), Expect = 0.0
Identities = 568/1249 (45%), Positives = 800/1249 (63%), Gaps = 7/1249 (0%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDP-NST 217
+S+ ++RY +DRL + VG + + GV LPLM +I G+++ +F ++G + + N +
Sbjct: 33 VSVLTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLIFGDMTDSFASVGNVSKNSTNMS 92
Query: 218 ASEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVM 397
++K A A+ E+ Y +G G+ ++Q S + + + ++ R++FFH++M
Sbjct: 93 EADKRAMFAKLEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFHAIM 152
Query: 398 RQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
QEI W+D + G L+ +L D++ ++ EG GDK+G+ FQ MA F GGF + FT W LTL
Sbjct: 153 NQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTL 212
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
+++++SP + + YA AG +AEEVL +IRTVIAF GQ+ E +R
Sbjct: 213 VILAISPVLGLSAGIWAKILSSFTDKELHAYAKAGAVAEEVLAAIRTVIAFGGQKKELER 272
Query: 758 YEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFF 937
Y + LE K+ GIKK+ + + F++IYASY LAFW GT+ V S G VLTVFF
Sbjct: 273 YNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYSIGQVLTVFF 332
Query: 938 SVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNK 1117
SV++G+ ++GQA A GAA ++++ID P ID++S G P I G +
Sbjct: 333 SVLIGAFSVGQASPNIEAFANARGAAYEVFKIIDNKPSIDSFSKSGHKPDNIQGNLEFKN 392
Query: 1118 VEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDI 1297
+ F+YP+R +V+ILKG++L + GQTVALVG+SGCGKST +QL+QR Y+P G + ID
Sbjct: 393 IHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQ 452
Query: 1298 PIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTF 1477
I N++YLR+++GVVSQEP LF T+I +NIRYGR DV+ ++I +A+KEANA DFI
Sbjct: 453 DIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKL 512
Query: 1478 PEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENA 1657
P +TLVG+RG Q+SGGQKQRIAIARALVRNPKILLLDEATSALD ESE++VQ+AL+ A
Sbjct: 513 PHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKA 572
Query: 1658 SRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFA---D 1828
GRTTIVIAHRLSTVRNAD I G ++E G H+ L+ +KG+Y +LV Q +
Sbjct: 573 REGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTAGNEIE 632
Query: 1829 VDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXX 2008
+ ++ K + E +S+ GS S +
Sbjct: 633 LGNEACKSKDEIDNLDMSSKDSGS-------SLIRRRSTRKSICGPHDQDRKLSTKEALD 685
Query: 2009 XGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSN--PDRDQM 2182
A+ ++IL+ EW Y +I G + PAFS+ FS+++ VF+N P Q
Sbjct: 686 EDVPPASFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFSKVVGVFTNGGPPETQ- 744
Query: 2183 KKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPK 2362
+++ + ++L+FL+L + + Q FG A E LT R+R V++++LRQD ++FD PK
Sbjct: 745 RQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPK 804
Query: 2363 HSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFM 2542
++ G +TTRLA DA +K A RL IF IA++G G+ I+ YGWQ+ L++AI P +
Sbjct: 805 NTTGALTTRLANDAAQVKGATGSRLAVIFQNIANLGTGIIISLIYGWQLTLLLLAIVPII 864
Query: 2543 AVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPH 2722
A+ + MK G A D KE+E +GK A EAIEN RTV +LT + K ++ L P+
Sbjct: 865 AIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPY 924
Query: 2723 GGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFG 2902
+ KA + G+T+ F ++ +F+YAA FRFG +L+ + LM ENVL V AI F
Sbjct: 925 RNAMKKAHVFGITFFFTQAMMYFSYAACFRFGAYLVTQQ--LMTFENVLLVFSAIVFGAM 982
Query: 2903 TIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYP-QLSGEVKLNKVFFRYPE 3079
+G +S+ P+Y KAT +A I ++E+ P ID ++ G P L G V+ + F YP
Sbjct: 983 AVGQVSSFAPDYAKATVSASHIIRIIEKTPEIDSYSTQGLKPNMLEGNVQFSGFVFNYPT 1042
Query: 3080 RPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNP 3259
RP++P+LQGL++ VK GQTLALVG SGCGKSTV+ LLER YDP+ G+V +D +++Q+N
Sbjct: 1043 RPSIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNV 1102
Query: 3260 KHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYE 3439
+ LR + +VSQEPILFD SI ENI YG ++E+I A +ANIH+FID LPD Y
Sbjct: 1103 QWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSYEEIVRAAKEANIHQFIDSLPDKYN 1162
Query: 3440 TRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRT 3619
TRVG+KGTQLSGGQKQRIAIARAL+R P ILLLDEATSALDTESEK VQ ALD A + RT
Sbjct: 1163 TRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRT 1222
Query: 3620 CIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQS 3766
CIV+AHRLSTI NA I+V++NG+V E GTH +L+A++G YF++ Q+
Sbjct: 1223 CIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQA 1271
Score = 408 bits (1049), Expect = e-112
Identities = 233/580 (40%), Positives = 339/580 (58%), Gaps = 4/580 (0%)
Frame = +2
Query: 98 VGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHEVIQNCL 277
VGI + G P S+I V F G P T + + FS L
Sbjct: 709 VGIFCAIINGGLQPAFSVIFSKVVGVFTNGG-----PPETQRQNSNL---FS-------L 753
Query: 278 KYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYD--KNTSGTLSNK 451
++ LG F FLQ F E L+ R R F S++RQ+++W+D KNT+G L+ +
Sbjct: 754 LFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTR 813
Query: 452 LFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXXX 631
L ++ +V+ TG ++ + FQ +A G ++ Y W LTL+++++ P + I G+
Sbjct: 814 LANDAAQVKGATGSRLAVIFQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMK 873
Query: 632 XXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFL 811
+ +G IA E + + RTV++ ++ Y +L+ + +KK+ +
Sbjct: 874 MLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNAMKKAHV 933
Query: 812 IGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQFAT 991
G ++Y SY F G V + VL VF +++ G+MA+GQ
Sbjct: 934 FGITFFFTQAMMYFSYAACFRFGAYLVTQQLMTFENVLLVFSAIVFGAMAVGQVSSFAPD 993
Query: 992 IGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKGVS 1171
A +A+ + +I++ PEID+YST+G P+ + G + + F YPTR + +L+G+S
Sbjct: 994 YAKATVSASHIIRIIEKTPEIDSYSTQGLKPNMLEGNVQFSGFVFNYPTRPSIPVLQGLS 1053
Query: 1172 LDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVS 1351
L+ + GQT+ALVGSSGCGKST++QLL+RFY+P AG + +D I+ N+++LR +G+VS
Sbjct: 1054 LEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAQLGIVS 1113
Query: 1352 QEPNLFNTSIEQNIRYGRSD--VSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQMS 1525
QEP LF+ SI +NI YG + VS E+I RA KEAN FI + P+ NT VGD+G Q+S
Sbjct: 1114 QEPILFDCSIAENIAYGDNSRVVSYEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLS 1173
Query: 1526 GGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLSTV 1705
GGQKQRIAIARALVR P ILLLDEATSALD ESE +VQ AL+ A GRT IVIAHRLST+
Sbjct: 1174 GGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTI 1233
Query: 1706 RNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFA 1825
+NAD I+V++ G+V E GTH+ L+ QKG+Y +V Q A
Sbjct: 1234 QNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQAGA 1273
Score = 380 bits (976), Expect = e-103
Identities = 226/586 (38%), Positives = 328/586 (55%), Gaps = 18/586 (3%)
Frame = +2
Query: 2066 IYXXXXXXXXLIQGAVMPAFSLFFSQIINVF-------------SNPDRDQM----KKDG 2194
+Y +I G +P L F + + F S D+ M +++
Sbjct: 48 LYMLVGTLAAIIHGVALPLMMLIFGDMTDSFASVGNVSKNSTNMSEADKRAMFAKLEEEM 107
Query: 2195 HFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPG 2374
+A + + A Q S + +AA R +IR K + ++ Q+ +FD+ H G
Sbjct: 108 TTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFHAIMNQEIGWFDV--HDVG 165
Query: 2375 RITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQ 2554
+ TRL D I I ++G F A+A+ GG I F GW++ +++AI P + +
Sbjct: 166 ELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTLVILAISPVLGLSA 225
Query: 2555 ALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNI 2734
+ K + AG A E + IRTV A Q K + ++L+ I
Sbjct: 226 GIWAKILSSFTDKELHAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEAKRLGI 285
Query: 2735 SKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGF 2914
KAI ++ G A + + +YA AF +G L+ K + VL V F++ ++G
Sbjct: 286 KKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYSIG--QVLTVFFSVLIGAFSVGQ 343
Query: 2915 AASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKLNKVFFRYPERPAV 3091
A+ + A AA +F +++ +P ID + SG P + G ++ + F YP R V
Sbjct: 344 ASPNIEAFANARGAAYEVFKIIDNKPSIDSFSKSGHKPDNIQGNLEFKNIHFSYPSRKEV 403
Query: 3092 PILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLR 3271
IL+GLN+ VK GQT+ALVG SGCGKST + L++RLYDPL+G V++D D+R +N ++LR
Sbjct: 404 QILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRYLR 463
Query: 3272 KHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVG 3451
+ I +VSQEP+LF T+I ENI YG + + T ++IE A +AN + FI +LP ++T VG
Sbjct: 464 EIIGVVSQEPVLFATTIAENIRYGRE--DVTMDEIEKAVKEANAYDFIMKLPHQFDTLVG 521
Query: 3452 EKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVV 3631
E+G QLSGGQKQRIAIARAL+RNPKILLLDEATSALDTESE VQ ALD A + RT IV+
Sbjct: 522 ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVI 581
Query: 3632 AHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSS 3769
AHRLST+ NA I G +VEQG H+EL+ ++G YF L Q++
Sbjct: 582 AHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTA 627
>gi|22775296|gb|AAN07779.1| multidrug resistance p-glycoprotein
[Macaca mulatta]
Length = 1283
Score = 1080 bits (2794), Expect = 0.0
Identities = 569/1254 (45%), Positives = 794/1254 (62%), Gaps = 12/1254 (0%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTI-------F 199
+S+F ++RY++ +D+L + VGI+ + G GLPLM ++ G+++ F G + F
Sbjct: 34 VSVFSMFRYSNWLDKLYMVVGILAAIIHGAGLPLMMLVFGDMTDTFANAGNLGDLGALLF 93
Query: 200 LDPNSTASEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQ 379
+ NS+ ++ + Y +G G+ A ++Q S + + + ++ R+Q
Sbjct: 94 NNTNSSNITDTVPVMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQ 153
Query: 380 FFHSVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTY 559
FFH++MRQEI W+D + G L+ +L D++ ++ EG GDK+G+ FQ MA F GF V FT
Sbjct: 154 FFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTR 213
Query: 560 DWLLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQ 739
W LTL+++++SP + + YA AG +AEEVL +IRTVIAF GQ
Sbjct: 214 GWKLTLVILAISPVLGVSAAAWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQ 273
Query: 740 EYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGT 919
+ E +RY LE K+ GIKK+ + + F++IYASY LAFW GT V S G
Sbjct: 274 KKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSKEYSIGQ 333
Query: 920 VLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISG 1099
VLTVFFSV++G+ ++GQA A GAA ++++ID P ID+YS G P I G
Sbjct: 334 VLTVFFSVLIGAFSVGQASPSIEAFANARGAAFEIFKIIDNKPSIDSYSKSGHKPDNIKG 393
Query: 1100 RISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQ 1279
+ V F+YP+R +VKILKG++L Q GQTVALVG+SGCGKST +QL+QR Y+P G
Sbjct: 394 NLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGM 453
Query: 1280 ILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAA 1459
+ +D I N+++LR+++GVVSQEP LF T+I +NIRYGR DV+ ++I +A+KEANA
Sbjct: 454 VSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAY 513
Query: 1460 DFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQ 1639
DFI P+ +TLVG+RG Q+SGGQKQRIAIARALVRNPKILLLDEATSALD ESE++VQ
Sbjct: 514 DFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQ 573
Query: 1640 SALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQV 1819
AL+ A +GRTTIVIAHRLSTVRNAD I G ++E G H+ L+++KG+Y +LV Q
Sbjct: 574 VALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQT 633
Query: 1820 FA---DVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXX 1990
++++ + ++E +S GS S +
Sbjct: 634 AGNEIELENAADESKSEIDTLEMSSHDSGS-------SLIRKRSTRRSVRGSQGQDRKLS 686
Query: 1991 XXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFS-NP 2167
+ ++I++ EW Y +I G + PAF++ FS+II +F+ N
Sbjct: 687 TKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAVIFSKIIGIFTRND 746
Query: 2168 DRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATY 2347
D + +++ + ++L+FLVL V + Q FG A E LT R+R V+R++LRQD ++
Sbjct: 747 DAETKRQNSNLFSLLFLVLGIVSFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSW 806
Query: 2348 FDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMA 2527
FD PK++ G +TTRLA DA +K AI RL I IA++G G+ I+ YGWQ+ L++A
Sbjct: 807 FDDPKNTTGALTTRLANDAAQVKGAIGSRLAIITQNIANLGTGIIISLIYGWQLTLLLLA 866
Query: 2528 IFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSH 2707
I P +A+ + MK G A D KE+E AGK A EAIEN RTV +LT + K +++
Sbjct: 867 IVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTQEQKFEHMYDQS 926
Query: 2708 LDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAI 2887
L P+ ++ KA I G+T+ F ++ +F+YA FRFG +L+ + LM E+VL V A+
Sbjct: 927 LQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLV--AHSLMSFEDVLLVFSAV 984
Query: 2888 SFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKLNKVF 3064
F +G +S+ P+Y KA +A I ++E+ P ID ++ G P L G V N+V
Sbjct: 985 VFGAMAVGQVSSFAPDYAKAKVSAAHIIMIIEKTPLIDSYSTEGLKPNTLEGNVTFNEVV 1044
Query: 3065 FRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDL 3244
F YP R +P+LQGL++ VK GQTLALVG SGCGKSTV+ LLER YDPL G V +D ++
Sbjct: 1045 FNYPTRLDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEI 1104
Query: 3245 RQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDEL 3424
+Q+N + LR H+ +VSQEPILFD SI ENI YG + E+I A +ANIH FI+ L
Sbjct: 1105 KQLNVQWLRAHLGIVSQEPILFDCSISENIAYGDNSRVVSQEEIVRAAKEANIHAFIESL 1164
Query: 3425 PDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAA 3604
P+ Y TRVG+KGTQLSGGQKQRIAIARAL+R P ILLLDEATSALDTESEK VQ ALD A
Sbjct: 1165 PNKYSTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKA 1224
Query: 3605 AKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQS 3766
+ RTCIV+AHRLSTI NA I+V +NG+V E GTH +L+A++G YF++ Q+
Sbjct: 1225 REGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA 1278
Score = 412 bits (1058), Expect = e-113
Identities = 222/521 (42%), Positives = 325/521 (61%), Gaps = 4/521 (0%)
Frame = +2
Query: 275 LKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYD--KNTSGTLSN 448
L ++ LG F FLQ F E L+ R R F S++RQ+++W+D KNT+G L+
Sbjct: 760 LLFLVLGIVSFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTT 819
Query: 449 KLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXX 628
+L ++ +V+ G ++ + Q +A G ++ Y W LTL+++++ P + I G+
Sbjct: 820 RLANDAAQVKGAIGSRLAIITQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEM 879
Query: 629 XXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSF 808
+ AG IA E + + RTV++ ++ Y+ +L+ + ++K+
Sbjct: 880 KMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTQEQKFEHMYDQSLQVPYRNSLRKAH 939
Query: 809 LIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQFA 988
+ G + ++Y SY F G V + VL VF +V+ G+MA+GQ
Sbjct: 940 IFGITFSFTQAMMYFSYAGCFRFGAYLVAHSLMSFEDVLLVFSAVVFGAMAVGQVSSFAP 999
Query: 989 TIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKGV 1168
A +AA + +I++ P ID+YSTEG P+ + G ++ N+V F YPTR D+ +L+G+
Sbjct: 1000 DYAKAKVSAAHIIMIIEKTPLIDSYSTEGLKPNTLEGNVTFNEVVFNYPTRLDIPVLQGL 1059
Query: 1169 SLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVV 1348
SL+ + GQT+ALVGSSGCGKST++QLL+RFY+P AG++L+D I+ N+++LR +G+V
Sbjct: 1060 SLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKQLNVQWLRAHLGIV 1119
Query: 1349 SQEPNLFNTSIEQNIRYGRSD--VSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQM 1522
SQEP LF+ SI +NI YG + VS E+I RA KEAN FI++ P +T VGD+G Q+
Sbjct: 1120 SQEPILFDCSISENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTRVGDKGTQL 1179
Query: 1523 SGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLST 1702
SGGQKQRIAIARALVR P ILLLDEATSALD ESE +VQ AL+ A GRT IVIAHRLST
Sbjct: 1180 SGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLST 1239
Query: 1703 VRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFA 1825
++NAD I+V + G+V E GTH+ L+ QKG+Y +V Q A
Sbjct: 1240 IQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGA 1280
Score = 379 bits (974), Expect = e-103
Identities = 232/608 (38%), Positives = 336/608 (55%), Gaps = 27/608 (4%)
Frame = +2
Query: 2027 NLFKILRYARPEWI---YXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDR-------- 2173
++F + RY+ W+ Y +I GA +P L F + + F+N
Sbjct: 35 SVFSMFRYSN--WLDKLYMVVGILAAIIHGAGLPLMMLVFGDMTDTFANAGNLGDLGALL 92
Query: 2174 ---------------DQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRS 2308
+++D +A + + A + Q S + +AA R +IR
Sbjct: 93 FNNTNSSNITDTVPVMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRK 152
Query: 2309 KVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIA 2488
+ + ++RQ+ +FD+ H G + TRL D I I ++G F ++A+ G +
Sbjct: 153 QFFHAIMRQEIGWFDV--HDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVG 210
Query: 2489 FYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQAL 2668
F GW++ +++AI P + V A K + AG A E + IRTV A
Sbjct: 211 FTRGWKLTLVILAISPVLGVSAAAWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAF 270
Query: 2669 TLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVL 2848
Q K + +L+ I KAI ++ G A + + +YA AF +G L+ K
Sbjct: 271 GGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSKEYS 330
Query: 2849 MEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYP 3028
+ VL V F++ ++G A+ + A AA IF +++ +P ID + SG P
Sbjct: 331 IG--QVLTVFFSVLIGAFSVGQASPSIEAFANARGAAFEIFKIIDNKPSIDSYSKSGHKP 388
Query: 3029 Q-LSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYD 3205
+ G ++ V F YP R V IL+GLN+ V+ GQT+ALVG SGCGKST + L++RLYD
Sbjct: 389 DNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYD 448
Query: 3206 PLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETA 3385
P EG V+VD D+R +N + LR+ I +VSQEP+LF T+I ENI YG + + T ++IE A
Sbjct: 449 PTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRE--DVTMDEIEKA 506
Query: 3386 CSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDT 3565
+AN + FI +LP ++T VGE+G QLSGGQKQRIAIARAL+RNPKILLLDEATSALDT
Sbjct: 507 VKEANAYDFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDT 566
Query: 3566 ESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYF 3745
ESE VQVALD A K RT IV+AHRLST+ NA I +G +VE+G H+EL+ ++G YF
Sbjct: 567 ESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYF 626
Query: 3746 ALTQKQSS 3769
L Q++
Sbjct: 627 KLVTMQTA 634
>gi|31442763|gb|AAN07780.2| multidrug resistance p-glycoprotein
[Macaca fascicularis]
Length = 1283
Score = 1078 bits (2789), Expect = 0.0
Identities = 568/1254 (45%), Positives = 793/1254 (62%), Gaps = 12/1254 (0%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTI-------F 199
+S+F ++RY++ +D+L + VG + + G GLPLM ++ G+++ F G + F
Sbjct: 34 VSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGDMTDTFANAGNLGDLGALLF 93
Query: 200 LDPNSTASEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQ 379
+ NS+ ++ + Y +G G+ A ++Q S + + + ++ R+Q
Sbjct: 94 NNTNSSNITDTVPVMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQ 153
Query: 380 FFHSVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTY 559
FFH++MRQEI W+D + G L+ +L D++ ++ EG GDK+G+ FQ MA F GF V FT
Sbjct: 154 FFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTR 213
Query: 560 DWLLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQ 739
W LTL+++++SP + + YA AG +AEEVL +IRTVIAF GQ
Sbjct: 214 GWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQ 273
Query: 740 EYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGT 919
+ E +RY LE K+ GIKK+ + + F++IYASY LAFW GT V S G
Sbjct: 274 KKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSKEYSIGQ 333
Query: 920 VLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISG 1099
VLTVFFSV++G+ ++GQA A GAA ++++ID P ID+YS G P I G
Sbjct: 334 VLTVFFSVLIGAFSVGQASPSIEAFANARGAAFEIFKIIDNKPSIDSYSKSGHKPDNIKG 393
Query: 1100 RISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQ 1279
+ V F+YP+R +VKILKG++L Q GQTVALVG+SGCGKST +QL+QR Y+P G
Sbjct: 394 NLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGM 453
Query: 1280 ILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAA 1459
+ +D I N+++LR+++GVVSQEP LF T+I +NIRYGR DV+ ++I +A+KEANA
Sbjct: 454 VSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAY 513
Query: 1460 DFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQ 1639
DFI P+ +TLVG+RG Q+SGGQKQRIAIARALVRNPKILLLDEATSALD ESE++VQ
Sbjct: 514 DFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQ 573
Query: 1640 SALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQV 1819
AL+ A +GRTTIVIAHRLSTVRNAD I G ++E G H+ L+++KG+Y +LV Q
Sbjct: 574 VALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQT 633
Query: 1820 FA---DVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXX 1990
++++ + ++E +S GS S +
Sbjct: 634 AGNEIELENAADESKSEIDTLEMSSHDSGS-------SLIRKRSTRRSVRGSQGQDRKLS 686
Query: 1991 XXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFS-NP 2167
+ ++I++ EW Y +I G + PAF++ FS+II +F+ N
Sbjct: 687 TKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAVIFSKIIGIFTRND 746
Query: 2168 DRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATY 2347
D + +++ + ++L+FLVL V + Q FG A E LT R+R V+R++LRQD ++
Sbjct: 747 DAETKRQNSNLFSLLFLVLGIVSFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSW 806
Query: 2348 FDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMA 2527
FD PK++ G +TTRLA DA +K AI RL I IA++G G+ I+ YGWQ+ L++A
Sbjct: 807 FDDPKNTTGALTTRLANDAAQVKGAIGSRLAIITQNIANLGTGIIISLIYGWQLTLLLLA 866
Query: 2528 IFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSH 2707
I P +A+ + MK G A D KE+E AGK A EAIEN RTV +LT + K +++
Sbjct: 867 IVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTQEQKFEHMYDQS 926
Query: 2708 LDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAI 2887
L P+ ++ KA I G+T+ F ++ +F+YA FRFG +L+ + LM E+VL V A+
Sbjct: 927 LQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLV--AHSLMSFEDVLLVFSAV 984
Query: 2888 SFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKLNKVF 3064
F +G +S+ P+Y KA +A I ++E+ P ID ++ G P L G V N+V
Sbjct: 985 VFGAMAVGQVSSFAPDYAKAKVSAAHIIMIIEKTPLIDSYSTEGLKPNTLEGNVTFNEVV 1044
Query: 3065 FRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDL 3244
F YP R +P+LQGL++ VK GQTLALVG SGCGKSTV+ LLER YDPL G V +D ++
Sbjct: 1045 FNYPTRLDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEI 1104
Query: 3245 RQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDEL 3424
+Q+N + LR H+ +VSQEPILFD SI ENI YG + E+I A +ANIH FI+ L
Sbjct: 1105 KQLNVQWLRAHLGIVSQEPILFDCSISENIAYGDNSRVVSQEEIVRAAKEANIHAFIESL 1164
Query: 3425 PDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAA 3604
P+ Y TRVG+KGTQLSGGQKQRIAIARAL+R P ILLLDEATSALDTESEK VQ ALD A
Sbjct: 1165 PNKYSTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKA 1224
Query: 3605 AKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQS 3766
+ RTCIV+AHRLSTI NA I+V +NG+V E GTH +L+A++G YF++ Q+
Sbjct: 1225 REGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA 1278
Score = 412 bits (1058), Expect = e-113
Identities = 222/521 (42%), Positives = 325/521 (61%), Gaps = 4/521 (0%)
Frame = +2
Query: 275 LKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYD--KNTSGTLSN 448
L ++ LG F FLQ F E L+ R R F S++RQ+++W+D KNT+G L+
Sbjct: 760 LLFLVLGIVSFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTT 819
Query: 449 KLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXX 628
+L ++ +V+ G ++ + Q +A G ++ Y W LTL+++++ P + I G+
Sbjct: 820 RLANDAAQVKGAIGSRLAIITQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEM 879
Query: 629 XXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSF 808
+ AG IA E + + RTV++ ++ Y+ +L+ + ++K+
Sbjct: 880 KMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTQEQKFEHMYDQSLQVPYRNSLRKAH 939
Query: 809 LIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQFA 988
+ G + ++Y SY F G V + VL VF +V+ G+MA+GQ
Sbjct: 940 IFGITFSFTQAMMYFSYAGCFRFGAYLVAHSLMSFEDVLLVFSAVVFGAMAVGQVSSFAP 999
Query: 989 TIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKGV 1168
A +AA + +I++ P ID+YSTEG P+ + G ++ N+V F YPTR D+ +L+G+
Sbjct: 1000 DYAKAKVSAAHIIMIIEKTPLIDSYSTEGLKPNTLEGNVTFNEVVFNYPTRLDIPVLQGL 1059
Query: 1169 SLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVV 1348
SL+ + GQT+ALVGSSGCGKST++QLL+RFY+P AG++L+D I+ N+++LR +G+V
Sbjct: 1060 SLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKQLNVQWLRAHLGIV 1119
Query: 1349 SQEPNLFNTSIEQNIRYGRSD--VSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQM 1522
SQEP LF+ SI +NI YG + VS E+I RA KEAN FI++ P +T VGD+G Q+
Sbjct: 1120 SQEPILFDCSISENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTRVGDKGTQL 1179
Query: 1523 SGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLST 1702
SGGQKQRIAIARALVR P ILLLDEATSALD ESE +VQ AL+ A GRT IVIAHRLST
Sbjct: 1180 SGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLST 1239
Query: 1703 VRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFA 1825
++NAD I+V + G+V E GTH+ L+ QKG+Y +V Q A
Sbjct: 1240 IQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGA 1280
Score = 379 bits (974), Expect = e-103
Identities = 231/608 (37%), Positives = 337/608 (54%), Gaps = 27/608 (4%)
Frame = +2
Query: 2027 NLFKILRYARPEWI---YXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDR-------- 2173
++F + RY+ W+ Y +I GA +P L F + + F+N
Sbjct: 35 SVFSMFRYSN--WLDKLYMVVGTLAAIIHGAGLPLMMLVFGDMTDTFANAGNLGDLGALL 92
Query: 2174 ---------------DQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRS 2308
+++D +A + + A + Q S + +AA R +IR
Sbjct: 93 FNNTNSSNITDTVPVMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRK 152
Query: 2309 KVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIA 2488
+ + ++RQ+ +FD+ H G + TRL D I I ++G F ++A+ G +
Sbjct: 153 QFFHAIMRQEIGWFDV--HDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVG 210
Query: 2489 FYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQAL 2668
F GW++ +++AI P + + A+ K + AG A E + IRTV A
Sbjct: 211 FTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAF 270
Query: 2669 TLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVL 2848
Q K + +L+ I KAI ++ G A + + +YA AF +G L+ K
Sbjct: 271 GGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSKEYS 330
Query: 2849 MEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYP 3028
+ VL V F++ ++G A+ + A AA IF +++ +P ID + SG P
Sbjct: 331 IG--QVLTVFFSVLIGAFSVGQASPSIEAFANARGAAFEIFKIIDNKPSIDSYSKSGHKP 388
Query: 3029 Q-LSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYD 3205
+ G ++ V F YP R V IL+GLN+ V+ GQT+ALVG SGCGKST + L++RLYD
Sbjct: 389 DNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYD 448
Query: 3206 PLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETA 3385
P EG V+VD D+R +N + LR+ I +VSQEP+LF T+I ENI YG + + T ++IE A
Sbjct: 449 PTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRE--DVTMDEIEKA 506
Query: 3386 CSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDT 3565
+AN + FI +LP ++T VGE+G QLSGGQKQRIAIARAL+RNPKILLLDEATSALDT
Sbjct: 507 VKEANAYDFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDT 566
Query: 3566 ESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYF 3745
ESE VQVALD A K RT IV+AHRLST+ NA I +G +VE+G H+EL+ ++G YF
Sbjct: 567 ESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYF 626
Query: 3746 ALTQKQSS 3769
L Q++
Sbjct: 627 KLVTMQTA 634
>gi|2506118|sp|P08183|MDR1_HUMAN Multidrug resistance protein 1
(P-glycoprotein 1) (CD243 antigen)
gi|1070659|pir||DVHU1 multidrug resistance protein 1 - human
gi|386862|gb|AAA59576.1| P glycoprotein
Length = 1280
Score = 1078 bits (2788), Expect = 0.0
Identities = 571/1261 (45%), Positives = 794/1261 (62%), Gaps = 16/1261 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+S+F ++RY++ +D+L + VG + + G GLPLM ++ G ++ F G + ++
Sbjct: 34 VSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNIT 93
Query: 221 SEKAAARAEFSHEVIQNCLKYVY----LGCGIFAAGFLQASCFMVICEKLSNRFRRQFFH 388
+ F + ++ +Y Y +G G+ A ++Q S + + + ++ R+QFFH
Sbjct: 94 NRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFH 153
Query: 389 SVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWL 568
++MRQEI W+D + G L+ +L D++ ++ EG GDK+G+ FQ MA F GF V FT W
Sbjct: 154 AIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWK 213
Query: 569 LTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYE 748
LTL+++++SP + + YA AG +AEEVL +IRTVIAF GQ+ E
Sbjct: 214 LTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKE 273
Query: 749 CKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLT 928
+RY LE K+ GIKK+ + + F++IYASY LAFW GT V SG G VLT
Sbjct: 274 LERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLT 333
Query: 929 VFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRIS 1108
VFFSV++G+ ++GQA A GAA ++++ID P ID+YS G P I G +
Sbjct: 334 VFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLE 393
Query: 1109 VNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILI 1288
V F+YP+R +VKILKG++L Q GQTVALVG+SGCGKST +QL+QR Y+P G + +
Sbjct: 394 FRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSV 453
Query: 1289 DDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFI 1468
D I N+++LR+++GVVSQEP LF T+I +NIRYGR +V+ ++I +A+KEANA DFI
Sbjct: 454 DGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFI 513
Query: 1469 KTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSAL 1648
P +TLVG+RG Q+SGGQKQRIAIARALVRNPKILLLDEATSALD ESE++VQ AL
Sbjct: 514 MKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVAL 573
Query: 1649 ENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQV--- 1819
+ A +GRTTIVIAHRLSTVRNAD I G ++E G H+ L+++KG+Y +LV Q
Sbjct: 574 DKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGN 633
Query: 1820 ---FADVDDKPKKK----EAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXX 1978
+ D+ K + E SR + RK S + SQ
Sbjct: 634 EVELENAADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQ--------------D 679
Query: 1979 XXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVF 2158
+ ++I++ EW Y +I G + PAF++ FS+II VF
Sbjct: 680 RKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVF 739
Query: 2159 SNPDRDQMKK-DGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQ 2335
+ D + K+ + + ++L+FL L + + Q FG A E LT R+R V+R++LRQ
Sbjct: 740 TRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQ 799
Query: 2336 DATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAF 2515
D ++FD PK++ G +TTRLA DA +K AI RL I IA++G G+ I+F YGWQ+
Sbjct: 800 DVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTL 859
Query: 2516 LVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNI 2695
L++AI P +A+ + MK G A D KE+E AGK A EAIEN RTV +LT + K ++
Sbjct: 860 LLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTQEQKFEHM 919
Query: 2696 FCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRV 2875
+ L P+ ++ KA I G+T+ F ++ +F+YA FRFG +L+ K LM E+VL V
Sbjct: 920 YAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHK--LMSFEDVLLV 977
Query: 2876 LFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKL 3052
A+ F +G +S+ P+Y KA +A I ++E+ P ID ++ G P L G V
Sbjct: 978 FSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTF 1037
Query: 3053 NKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVD 3232
+V F YP RP +P+LQGL++ VK GQTLALVG SGCGKSTV+ LLER YDPL G V +D
Sbjct: 1038 GEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLD 1097
Query: 3233 NNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKF 3412
+++++N + LR H+ +VSQEPILFD SI ENI YG + E+I A +ANIH F
Sbjct: 1098 GKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAF 1157
Query: 3413 IDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVA 3592
I+ LP+ Y T+VG+KGTQLSGGQKQRIAIARAL+R P ILLLDEATSALDTESEK VQ A
Sbjct: 1158 IESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEA 1217
Query: 3593 LDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSSN 3772
LD A + RTCIV+AHRLSTI NA I+V +NG+V E GTH +L+A++G YF++ Q+
Sbjct: 1218 LDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGT 1277
Query: 3773 Q 3775
+
Sbjct: 1278 K 1278
>gi|42741659|ref|NP_000918.2| ATP-binding cassette sub-family B member
1; multidrug resistance 1; P glycoprotein 1; doxorubicin
resistance; colchicin sensitivity [Homo sapiens]
Length = 1280
Score = 1077 bits (2785), Expect = 0.0
Identities = 570/1261 (45%), Positives = 794/1261 (62%), Gaps = 16/1261 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+S+F ++RY++ +D+L + VG + + G GLPLM ++ G ++ F G + ++
Sbjct: 34 VSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNIT 93
Query: 221 SEKAAARAEFSHEVIQNCLKYVY----LGCGIFAAGFLQASCFMVICEKLSNRFRRQFFH 388
+ F + ++ +Y Y +G G+ A ++Q S + + + ++ R+QFFH
Sbjct: 94 NRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFH 153
Query: 389 SVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWL 568
++MRQEI W+D + G L+ +L D++ ++ EG GDK+G+ FQ MA F GF V FT W
Sbjct: 154 AIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWK 213
Query: 569 LTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYE 748
LTL+++++SP + + YA AG +AEEVL +IRTVIAF GQ+ E
Sbjct: 214 LTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKE 273
Query: 749 CKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLT 928
+RY LE K+ GIKK+ + + F++IYASY LAFW GT V SG G VLT
Sbjct: 274 LERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLT 333
Query: 929 VFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRIS 1108
VFFSV++G+ ++GQA A GAA ++++ID P ID+YS G P I G +
Sbjct: 334 VFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLE 393
Query: 1109 VNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILI 1288
V F+YP+R +VKILKG++L Q GQTVALVG+SGCGKST +QL+QR Y+P G + +
Sbjct: 394 FRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSV 453
Query: 1289 DDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFI 1468
D I N+++LR+++GVVSQEP LF T+I +NIRYGR +V+ ++I +A+KEANA DFI
Sbjct: 454 DGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFI 513
Query: 1469 KTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSAL 1648
P +TLVG+RG Q+SGGQKQRIAIARALVRNPKILLLDEATSALD ESE++VQ AL
Sbjct: 514 MKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVAL 573
Query: 1649 ENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQV--- 1819
+ A +GRTTIVIAHRLSTVRNAD I G ++E G H+ L+++KG+Y +LV Q
Sbjct: 574 DKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGN 633
Query: 1820 ---FADVDDKPKKK----EAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXX 1978
+ D+ K + E SR + RK S + SQ
Sbjct: 634 EVELENAADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQ--------------D 679
Query: 1979 XXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVF 2158
+ ++I++ EW Y +I G + PAF++ FS+II VF
Sbjct: 680 RKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVF 739
Query: 2159 SNPDRDQMKK-DGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQ 2335
+ D + K+ + + ++L+FL L + + Q FG A E LT R+R V+R++LRQ
Sbjct: 740 TRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQ 799
Query: 2336 DATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAF 2515
D ++FD PK++ G +TTRLA DA +K AI RL I IA++G G+ I+F YGWQ+
Sbjct: 800 DVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTL 859
Query: 2516 LVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNI 2695
L++AI P +A+ + MK G A D KE+E +GK A EAIEN RTV +LT + K ++
Sbjct: 860 LLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTQEQKFEHM 919
Query: 2696 FCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRV 2875
+ L P+ ++ KA I G+T+ F ++ +F+YA FRFG +L+ K LM E+VL V
Sbjct: 920 YAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHK--LMSFEDVLLV 977
Query: 2876 LFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKL 3052
A+ F +G +S+ P+Y KA +A I ++E+ P ID ++ G P L G V
Sbjct: 978 FSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTF 1037
Query: 3053 NKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVD 3232
+V F YP RP +P+LQGL++ VK GQTLALVG SGCGKSTV+ LLER YDPL G V +D
Sbjct: 1038 GEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLD 1097
Query: 3233 NNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKF 3412
+++++N + LR H+ +VSQEPILFD SI ENI YG + E+I A +ANIH F
Sbjct: 1098 GKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAF 1157
Query: 3413 IDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVA 3592
I+ LP+ Y T+VG+KGTQLSGGQKQRIAIARAL+R P ILLLDEATSALDTESEK VQ A
Sbjct: 1158 IESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEA 1217
Query: 3593 LDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSSN 3772
LD A + RTCIV+AHRLSTI NA I+V +NG+V E GTH +L+A++G YF++ Q+
Sbjct: 1218 LDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGT 1277
Query: 3773 Q 3775
+
Sbjct: 1278 K 1278
>gi|46394984|gb|AAS91648.1| multidrug resistance protein;
P-glycoprotein [Macaca mulatta]
Length = 1283
Score = 1077 bits (2784), Expect = 0.0
Identities = 568/1254 (45%), Positives = 792/1254 (62%), Gaps = 12/1254 (0%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTI-------F 199
+S+F ++RY++ +D+L + VG + + G GLPLM ++ G+++ F G + F
Sbjct: 34 VSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGDMTDTFANAGNLGDLGALLF 93
Query: 200 LDPNSTASEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQ 379
+ NS+ ++ + Y +G G+ A ++Q S + + + ++ R+Q
Sbjct: 94 NNTNSSNITDTVPVMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQ 153
Query: 380 FFHSVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTY 559
FFH++MRQEI W+D + G L+ +L D + ++ EG GDK+G+ FQ MA F GF V FT
Sbjct: 154 FFHAIMRQEIGWFDVHDVGELNTRLTDEVSKINEGIGDKIGMFFQSMATFFTGFIVGFTR 213
Query: 560 DWLLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQ 739
W LTL+++++SP + + YA AG +AEEVL +IRTVIAF GQ
Sbjct: 214 GWKLTLVILAISPILGLSAAAWAKILSSFTDKELLAYAKAGVVAEEVLAAIRTVIAFGGQ 273
Query: 740 EYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGT 919
+ E +RY LE K+ GIKK+ + + F++IYASY LAFW GT V S G
Sbjct: 274 KKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSKEYSIGQ 333
Query: 920 VLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISG 1099
VLTVFFSV++G+ ++GQA A GAA ++++ID P ID+YS G P I G
Sbjct: 334 VLTVFFSVLIGAFSVGQASPSIEAFANARGAAFEIFKIIDNKPSIDSYSKSGHKPDNIKG 393
Query: 1100 RISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQ 1279
+ V F+YP+R +VKILKG++L Q GQTVALVG+SGCGKST +QL+QR Y+P G
Sbjct: 394 NLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGM 453
Query: 1280 ILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAA 1459
+ +D I N+++LR+++GVVSQEP LF T+I +NIRYGR DV+ ++I +A+KEANA
Sbjct: 454 VSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAY 513
Query: 1460 DFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQ 1639
DFI P+ +TLVG+RG Q+SGGQKQRIAIARALVRNPKILLLDEATSALD ESE++VQ
Sbjct: 514 DFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQ 573
Query: 1640 SALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQV 1819
AL+ A +GRTTIVIAHRLSTVRNAD I G ++E G H+ L+++KG+Y +LV Q
Sbjct: 574 VALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQT 633
Query: 1820 FA---DVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXX 1990
++++ + ++E +S GS S +
Sbjct: 634 AGNEIELENAADESKSEIDTLEMSSHDSGS-------SLIRKRSTRRSVRGSQGQDRKLS 686
Query: 1991 XXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFS-NP 2167
+ ++I++ EW Y +I G + PAF++ FS+II +F+ N
Sbjct: 687 TKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAVIFSKIIGIFTRND 746
Query: 2168 DRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATY 2347
D + +++ + ++L+FLVL V + Q FG A E LT R+R V+R++LRQD ++
Sbjct: 747 DAETKQQNSNLFSLLFLVLGIVSFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSW 806
Query: 2348 FDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMA 2527
FD PK++ G +TTRLA DA +K AI RL I IA++G G+ I+ YGWQ+ L++A
Sbjct: 807 FDDPKNTTGALTTRLANDAAQVKGAIGSRLAIITQNIANLGTGIIISLIYGWQLTLLLLA 866
Query: 2528 IFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSH 2707
I P +A+ + MK G A D KE+E AGK A EAIEN RTV +LT + K +++
Sbjct: 867 IVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTQEQKFEHMYDQS 926
Query: 2708 LDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAI 2887
L P+ ++ KA I G+T+ F ++ +F+YA FRFG +L+ + LM E+VL V A+
Sbjct: 927 LQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLV--AHSLMSFEDVLLVFSAV 984
Query: 2888 SFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKLNKVF 3064
F +G +S+ P+Y KA +A I ++E+ P ID ++ G P L G V N+V
Sbjct: 985 VFGAMAVGQVSSFAPDYAKAKVSAAHIIMIIEKTPLIDSYSTEGLKPNTLEGNVTFNEVV 1044
Query: 3065 FRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDL 3244
F YP R +P+LQGL++ VK GQTLALVG SGCGKSTV+ LLER YDPL G V +D ++
Sbjct: 1045 FNYPTRLDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEI 1104
Query: 3245 RQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDEL 3424
+Q+N + LR H+ +VSQEPILFD SI ENI YG + E+I A +ANIH FI+ L
Sbjct: 1105 KQLNVQWLRAHLGIVSQEPILFDCSISENIAYGDNSRVVSQEEIVRAAKEANIHAFIESL 1164
Query: 3425 PDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAA 3604
P+ Y TRVG+KGTQLSGGQKQRIAIARAL+R P ILLLDEATSALDTESEK VQ ALD A
Sbjct: 1165 PNKYSTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKA 1224
Query: 3605 AKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQS 3766
+ RTCIV+AHRLSTI NA I+V +NG+V E GTH +L+A++G YF++ Q+
Sbjct: 1225 REGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA 1278
Score = 412 bits (1058), Expect = e-113
Identities = 222/521 (42%), Positives = 325/521 (61%), Gaps = 4/521 (0%)
Frame = +2
Query: 275 LKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYD--KNTSGTLSN 448
L ++ LG F FLQ F E L+ R R F S++RQ+++W+D KNT+G L+
Sbjct: 760 LLFLVLGIVSFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTT 819
Query: 449 KLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXX 628
+L ++ +V+ G ++ + Q +A G ++ Y W LTL+++++ P + I G+
Sbjct: 820 RLANDAAQVKGAIGSRLAIITQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEM 879
Query: 629 XXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSF 808
+ AG IA E + + RTV++ ++ Y+ +L+ + ++K+
Sbjct: 880 KMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTQEQKFEHMYDQSLQVPYRNSLRKAH 939
Query: 809 LIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQFA 988
+ G + ++Y SY F G V + VL VF +V+ G+MA+GQ
Sbjct: 940 IFGITFSFTQAMMYFSYAGCFRFGAYLVAHSLMSFEDVLLVFSAVVFGAMAVGQVSSFAP 999
Query: 989 TIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKGV 1168
A +AA + +I++ P ID+YSTEG P+ + G ++ N+V F YPTR D+ +L+G+
Sbjct: 1000 DYAKAKVSAAHIIMIIEKTPLIDSYSTEGLKPNTLEGNVTFNEVVFNYPTRLDIPVLQGL 1059
Query: 1169 SLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVV 1348
SL+ + GQT+ALVGSSGCGKST++QLL+RFY+P AG++L+D I+ N+++LR +G+V
Sbjct: 1060 SLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKQLNVQWLRAHLGIV 1119
Query: 1349 SQEPNLFNTSIEQNIRYGRSD--VSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQM 1522
SQEP LF+ SI +NI YG + VS E+I RA KEAN FI++ P +T VGD+G Q+
Sbjct: 1120 SQEPILFDCSISENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTRVGDKGTQL 1179
Query: 1523 SGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLST 1702
SGGQKQRIAIARALVR P ILLLDEATSALD ESE +VQ AL+ A GRT IVIAHRLST
Sbjct: 1180 SGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLST 1239
Query: 1703 VRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFA 1825
++NAD I+V + G+V E GTH+ L+ QKG+Y +V Q A
Sbjct: 1240 IQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGA 1280
Score = 377 bits (968), Expect = e-102
Identities = 230/608 (37%), Positives = 336/608 (54%), Gaps = 27/608 (4%)
Frame = +2
Query: 2027 NLFKILRYARPEWI---YXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDR-------- 2173
++F + RY+ W+ Y +I GA +P L F + + F+N
Sbjct: 35 SVFSMFRYSN--WLDKLYMVVGTLAAIIHGAGLPLMMLVFGDMTDTFANAGNLGDLGALL 92
Query: 2174 ---------------DQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRS 2308
+++D +A + + A + Q S + +AA R +IR
Sbjct: 93 FNNTNSSNITDTVPVMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRK 152
Query: 2309 KVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIA 2488
+ + ++RQ+ +FD+ H G + TRL + I I ++G F ++A+ G +
Sbjct: 153 QFFHAIMRQEIGWFDV--HDVGELNTRLTDEVSKINEGIGDKIGMFFQSMATFFTGFIVG 210
Query: 2489 FYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQAL 2668
F GW++ +++AI P + + A K + AG A E + IRTV A
Sbjct: 211 FTRGWKLTLVILAISPILGLSAAAWAKILSSFTDKELLAYAKAGVVAEEVLAAIRTVIAF 270
Query: 2669 TLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVL 2848
Q K + +L+ I KAI ++ G A + + +YA AF +G L+ K
Sbjct: 271 GGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSKEYS 330
Query: 2849 MEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYP 3028
+ VL V F++ ++G A+ + A AA IF +++ +P ID + SG P
Sbjct: 331 IG--QVLTVFFSVLIGAFSVGQASPSIEAFANARGAAFEIFKIIDNKPSIDSYSKSGHKP 388
Query: 3029 Q-LSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYD 3205
+ G ++ V F YP R V IL+GLN+ V+ GQT+ALVG SGCGKST + L++RLYD
Sbjct: 389 DNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYD 448
Query: 3206 PLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETA 3385
P EG V+VD D+R +N + LR+ I +VSQEP+LF T+I ENI YG + + T ++IE A
Sbjct: 449 PTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRE--DVTMDEIEKA 506
Query: 3386 CSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDT 3565
+AN + FI +LP ++T VGE+G QLSGGQKQRIAIARAL+RNPKILLLDEATSALDT
Sbjct: 507 VKEANAYDFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDT 566
Query: 3566 ESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYF 3745
ESE VQVALD A K RT IV+AHRLST+ NA I +G +VE+G H+EL+ ++G YF
Sbjct: 567 ESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYF 626
Query: 3746 ALTQKQSS 3769
L Q++
Sbjct: 627 KLVTMQTA 634
>gi|307180|gb|AAA59575.1| P-glycoprotein [Homo sapiens]
Length = 1280
Score = 1075 bits (2779), Expect = 0.0
Identities = 570/1261 (45%), Positives = 793/1261 (62%), Gaps = 16/1261 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+S+F ++RY++ +D+L + VG + + G GLPLM ++ G ++ F G + ++
Sbjct: 34 VSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNIT 93
Query: 221 SEKAAARAEFSHEVIQNCLKYVY----LGCGIFAAGFLQASCFMVICEKLSNRFRRQFFH 388
+ F + ++ +Y Y +G G+ A ++Q S + + + ++ R+QFFH
Sbjct: 94 NRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFH 153
Query: 389 SVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWL 568
++MRQEI W+D + G L+ +L D++ ++ E GDK+G+ FQ MA F GF V FT W
Sbjct: 154 AIMRQEIGWFDVHDVGELNTRLTDDVSKINEVIGDKIGMFFQSMATFFTGFIVGFTRGWK 213
Query: 569 LTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYE 748
LTL+++++SP + + YA AG +AEEVL +IRTVIAF GQ+ E
Sbjct: 214 LTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKE 273
Query: 749 CKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLT 928
+RY LE K+ GIKK+ + + F++IYASY LAFW GT V SG G VLT
Sbjct: 274 LERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLT 333
Query: 929 VFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRIS 1108
VFFSV++G+ ++GQA A GAA ++++ID P ID+YS G P I G +
Sbjct: 334 VFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLE 393
Query: 1109 VNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILI 1288
V F+YP+R +VKILKG++L Q GQTVALVG+SGCGKST +QL+QR Y+P G + +
Sbjct: 394 FRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSV 453
Query: 1289 DDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFI 1468
D I N+++LR+++GVVSQEP LF T+I +NIRYGR +V+ ++I +A+KEANA DFI
Sbjct: 454 DGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFI 513
Query: 1469 KTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSAL 1648
P +TLVG+RG Q+SGGQKQRIAIARALVRNPKILLLDEATSALD ESE++VQ AL
Sbjct: 514 MKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVAL 573
Query: 1649 ENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQV--- 1819
+ A +GRTTIVIAHRLSTVRNAD I G ++E G H+ L+++KG+Y +LV Q
Sbjct: 574 DKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGN 633
Query: 1820 ---FADVDDKPKKK----EAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXX 1978
+ D+ K + E SR + RK S + SQ
Sbjct: 634 EVELENAADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQ--------------D 679
Query: 1979 XXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVF 2158
+ ++I++ EW Y +I G + PAF++ FS+II VF
Sbjct: 680 RKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVF 739
Query: 2159 SNPDRDQMKK-DGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQ 2335
+ D + K+ + + ++L+FL L + + Q FG A E LT R+R V+R++LRQ
Sbjct: 740 TRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQ 799
Query: 2336 DATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAF 2515
D ++FD PK++ G +TTRLA DA +K AI RL I IA++G G+ I+F YGWQ+
Sbjct: 800 DVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTL 859
Query: 2516 LVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNI 2695
L++AI P +A+ + MK G A D KE+E AGK A EAIEN RTV +LT + K ++
Sbjct: 860 LLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTQEQKFEHM 919
Query: 2696 FCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRV 2875
+ L P+ ++ KA I G+T+ F ++ +F+YA FRFG +L+ K LM E+VL V
Sbjct: 920 YAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHK--LMSFEDVLLV 977
Query: 2876 LFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKL 3052
A+ F +G +S+ P+Y KA +A I ++E+ P ID ++ G P L G V
Sbjct: 978 FSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTF 1037
Query: 3053 NKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVD 3232
+V F YP RP +P+LQGL++ VK GQTLALVG SGCGKSTV+ LLER YDPL G V +D
Sbjct: 1038 GEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLD 1097
Query: 3233 NNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKF 3412
+++++N + LR H+ +VSQEPILFD SI ENI YG + E+I A +ANIH F
Sbjct: 1098 GKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAF 1157
Query: 3413 IDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVA 3592
I+ LP+ Y T+VG+KGTQLSGGQKQRIAIARAL+R P ILLLDEATSALDTESEK VQ A
Sbjct: 1158 IESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEA 1217
Query: 3593 LDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSSN 3772
LD A + RTCIV+AHRLSTI NA I+V +NG+V E GTH +L+A++G YF++ Q+
Sbjct: 1218 LDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGT 1277
Query: 3773 Q 3775
+
Sbjct: 1278 K 1278
>gi|25453402|ref|NP_596892.1| ATP-binding cassette, sub-family B
(MDR/TAP), member 1A; multiple drug resistant 1a [Rattus
norvegicus]
gi|34853968|ref|XP_346684.1| hypothetical protein XP_346683 [Rattus
norvegicus]
gi|7739773|gb|AAF69007.1| multidrug resistance protein 1a [Rattus
norvegicus]
Length = 1272
Score = 1075 bits (2779), Expect = 0.0
Identities = 564/1259 (44%), Positives = 794/1259 (62%), Gaps = 17/1259 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+S+ ++RY +DR + +G + + G+ LPLM ++ G+++ +F +G + + +
Sbjct: 33 VSVLTMFRYAGWLDRFYMLLGTLAAIIHGIALPLMMLVFGDMTDSFANVGN---NRSMSF 89
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
A+ E+ Y +G G+ ++Q S + + + ++ R++FFH++M
Sbjct: 90 YNATDIYAKLEDEMTTYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFFHAIMN 149
Query: 401 QEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLI 580
QEI W+D + G L+ +L D++ ++ EG GDK+G+ FQ MA F GGF + FT W LTL+
Sbjct: 150 QEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTLV 209
Query: 581 MMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRY 760
++++SP + + YA AG +AEEVL +IRTVIAF GQ+ E +RY
Sbjct: 210 ILAISPVLGLSAGIWAKILSSFTDKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKELERY 269
Query: 761 EDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFS 940
+ LE K+ GIKK+ + + F++IYASY LAFW GT+ V S G VLTVFFS
Sbjct: 270 NNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYTIGQVLTVFFS 329
Query: 941 VMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKV 1120
V++G+ ++GQA A GAA ++ +ID P ID++S G P I G + +
Sbjct: 330 VLIGAFSVGQASPNIEAFANARGAAYEVFSIIDNKPSIDSFSKSGHKPDNIQGNLEFKNI 389
Query: 1121 EFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIP 1300
F+YP+R DV+ILKG++L + GQTVALVG+SGCGKST +QLLQR Y+P G++ ID
Sbjct: 390 HFSYPSRKDVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEGEVSIDGQD 449
Query: 1301 IEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFP 1480
I N++YLR+++GVVSQEP LF T+I +NIRYGR +V+ ++I +A+KEANA DFI P
Sbjct: 450 IRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLP 509
Query: 1481 EGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENAS 1660
+TLVG+RG Q+SGGQKQRIAIARALVRNPKILLLDEATSALD ESE++VQ+AL+ A
Sbjct: 510 HKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAR 569
Query: 1661 RGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFAD---- 1828
GRTTIVIAHRLSTVRNAD I G ++E G H+ L+ +KG+Y +LV Q +
Sbjct: 570 EGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTAGNEIEL 629
Query: 1829 ----------VDDKP-KKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXX 1975
+D+ K++ + R+ S RK Q+ ++
Sbjct: 630 GNEACESKDGIDNVDMSSKDSGSSLIRRRSTRKSIRGPHDQDGELSTKEALDDD------ 683
Query: 1976 XXXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINV 2155
A+ ++IL+ EW Y +I G + PAFS+ FS+++ V
Sbjct: 684 -------------VPPASFWRILKLNSTEWPYFVVGVFCAIINGGLQPAFSIIFSKVVGV 730
Query: 2156 FSNPDRDQMKK-DGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLR 2332
F+ D ++++ + + ++L+FL+L + + Q FG A E LT R+R V++++LR
Sbjct: 731 FTKNDTPEIQRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLR 790
Query: 2333 QDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMA 2512
QD ++FD PK++ G +TTRLA DA +K A RL I IA++G G+ I+ YGWQ+
Sbjct: 791 QDISWFDDPKNTTGALTTRLANDAAQVKGATGSRLAVITQNIANLGTGIIISLIYGWQLT 850
Query: 2513 FLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYN 2692
L++AI P +A+ + MK G A D KE+E +GK A EAIEN RTV +LT + K
Sbjct: 851 LLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFET 910
Query: 2693 IFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLR 2872
++ L P+ + KA + G+T+ F ++ +F+YAA FRFG +L+ + LM ENVL
Sbjct: 911 MYAQSLQIPYRNALKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVARE--LMTFENVLL 968
Query: 2873 VLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVK 3049
V AI F +G +S+ P+Y KA +A I ++E+ P ID ++ G P L G VK
Sbjct: 969 VFSAIVFGAMAVGQVSSFAPDYAKAKVSASHIIRIIEKIPEIDSYSTEGLKPNMLEGNVK 1028
Query: 3050 LNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTV 3229
N V F YP RP +P+LQGL++ VK GQTLALVG SGCGKSTV+ LLER YDP+ G V +
Sbjct: 1029 FNGVMFNYPTRPNIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFL 1088
Query: 3230 DNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHK 3409
D +++Q+N + LR H+ +VSQEPILFD SI ENI YG +HE+I A +ANIH+
Sbjct: 1089 DGKEIKQLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSHEEIVKAAKEANIHQ 1148
Query: 3410 FIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQV 3589
FID LP+ Y TRVG+KGTQLSGGQKQRIAIARAL+R P ILLLDEATSALDTESEK VQ
Sbjct: 1149 FIDSLPEKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQE 1208
Query: 3590 ALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQS 3766
ALD A + RTCIV+AHRLSTI NA I+V++NGQV E GTH +L+A++G YF++ Q+
Sbjct: 1209 ALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGQVKEHGTHQQLLAQKGIYFSMVSVQA 1267
Score = 415 bits (1066), Expect = e-114
Identities = 224/521 (42%), Positives = 324/521 (61%), Gaps = 4/521 (0%)
Frame = +2
Query: 275 LKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYD--KNTSGTLSN 448
L ++ LG F FLQ F E L+ R R F S++RQ+I+W+D KNT+G L+
Sbjct: 749 LLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDISWFDDPKNTTGALTT 808
Query: 449 KLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXX 628
+L ++ +V+ TG ++ + Q +A G ++ Y W LTL+++++ P + I G+
Sbjct: 809 RLANDAAQVKGATGSRLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEM 868
Query: 629 XXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSF 808
+ +G IA E + + RTV++ ++ Y +L+ + +KK+
Sbjct: 869 KMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNALKKAH 928
Query: 809 LIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQFA 988
+ G + ++Y SY F G V + VL VF +++ G+MA+GQ
Sbjct: 929 VFGITFSFTQAMMYFSYAACFRFGAYLVARELMTFENVLLVFSAIVFGAMAVGQVSSFAP 988
Query: 989 TIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKGV 1168
A +A+ + +I++IPEID+YSTEG P+ + G + N V F YPTR ++ +L+G+
Sbjct: 989 DYAKAKVSASHIIRIIEKIPEIDSYSTEGLKPNMLEGNVKFNGVMFNYPTRPNIPVLQGL 1048
Query: 1169 SLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVV 1348
SL+ + GQT+ALVGSSGCGKST++QLL+RFY+P AG + +D I+ N+++LR +G+V
Sbjct: 1049 SLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEIKQLNVQWLRAHLGIV 1108
Query: 1349 SQEPNLFNTSIEQNIRYGRSD--VSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQM 1522
SQEP LF+ SI +NI YG + VS E+I +A KEAN FI + PE NT VGD+G Q+
Sbjct: 1109 SQEPILFDCSIAENIAYGDNSRVVSHEEIVKAAKEANIHQFIDSLPEKYNTRVGDKGTQL 1168
Query: 1523 SGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLST 1702
SGGQKQRIAIARALVR P ILLLDEATSALD ESE +VQ AL+ A GRT IVIAHRLST
Sbjct: 1169 SGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLST 1228
Query: 1703 VRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFA 1825
++NAD I+V++ GQV E GTH+ L+ QKG+Y +V Q A
Sbjct: 1229 IQNADLIVVIQNGQVKEHGTHQQLLAQKGIYFSMVSVQAGA 1269
Score = 385 bits (990), Expect = e-105
Identities = 230/598 (38%), Positives = 337/598 (55%), Gaps = 17/598 (2%)
Frame = +2
Query: 2027 NLFKILRYARPEWI---YXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQ------ 2179
++ + RYA W+ Y +I G +P L F + + F+N ++
Sbjct: 34 SVLTMFRYAG--WLDRFYMLLGTLAAIIHGIALPLMMLVFGDMTDSFANVGNNRSMSFYN 91
Query: 2180 -------MKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQD 2338
++ + +A + + A Q SL+ +AA R +IR K + ++ Q+
Sbjct: 92 ATDIYAKLEDEMTTYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFFHAIMNQE 151
Query: 2339 ATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFL 2518
+FD+ H G + TRL D I I ++G F A+A+ GG I F GW++ +
Sbjct: 152 IGWFDV--HDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTLV 209
Query: 2519 VMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIF 2698
++AI P + + + K + + AG A E + IRTV A Q K +
Sbjct: 210 ILAISPVLGLSAGIWAKILSSFTDKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKELERY 269
Query: 2699 CSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVL 2878
++L+ I KAI ++ G A + + +YA AF +G L+ K + VL V
Sbjct: 270 NNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYTIG--QVLTVF 327
Query: 2879 FAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKLN 3055
F++ ++G A+ + A AA +F++++ +P ID + SG P + G ++
Sbjct: 328 FSVLIGAFSVGQASPNIEAFANARGAAYEVFSIIDNKPSIDSFSKSGHKPDNIQGNLEFK 387
Query: 3056 KVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDN 3235
+ F YP R V IL+GLN+ VK GQT+ALVG SGCGKST + LL+RLYDP+EG V++D
Sbjct: 388 NIHFSYPSRKDVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEGEVSIDG 447
Query: 3236 NDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFI 3415
D+R +N ++LR+ I +VSQEP+LF T+I ENI YG + T ++IE A +AN + FI
Sbjct: 448 QDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRE--NVTMDEIEKAVKEANAYDFI 505
Query: 3416 DELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVAL 3595
+LP ++T VGE+G QLSGGQKQRIAIARAL+RNPKILLLDEATSALDTESE VQ AL
Sbjct: 506 MKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAAL 565
Query: 3596 DAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSS 3769
D A + RT IV+AHRLST+ NA I G +VEQG H+EL+ ++G YF L Q++
Sbjct: 566 DKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTA 623
>gi|45382457|ref|NP_990225.1| ABC transporter protein [Gallus gallus]
gi|3355757|emb|CAA08835.1| ABC transporter protein; P-glycoprotein
[Gallus gallus]
Length = 1288
Score = 1073 bits (2776), Expect = 0.0
Identities = 564/1246 (45%), Positives = 777/1246 (62%), Gaps = 2/1246 (0%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+S L+RY+S D+L++ G +++ A G LP+ II G+++ +FVT G + NS+
Sbjct: 45 VSPLALFRYSSCTDKLLMIFGSLLAIAHGTSLPIAMIIFGDMTDSFVTSGMTNITGNSSG 104
Query: 221 SEKAA-ARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVM 397
+A + E+ + Y + + A ++Q S + + + + R +FFH++M
Sbjct: 105 LNSSADVFNKLEEEMTRYAYYYSAIAAAVLVAAYIQTSFWTLAAGRQVKKIREKFFHAIM 164
Query: 398 RQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
RQEI W+D N +G L+ +L D++ ++ EG GDK+G Q F+ GF V F W LTL
Sbjct: 165 RQEIGWFDVNDAGELNTRLIDDVSKINEGIGDKIGFLIQSETTFLTGFIVGFIRGWKLTL 224
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
+++++SP + + YA AG +AEEVL+++RTVIAF GQE E KR
Sbjct: 225 VILAVSPVLGLSAALWAKILTAFTDKEQAAYAKAGAVAEEVLSAVRTVIAFGGQEKEIKR 284
Query: 758 YEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFF 937
Y LE K+ GI+K+ + + F++IYASY LAFW GT + + G VLTVFF
Sbjct: 285 YHKNLEDAKRIGIRKAITSNISMGAAFLLIYASYALAFWYGTTLILANEYSIGNVLTVFF 344
Query: 938 SVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNK 1117
SV++G+ ++GQ A GAA +++ +ID PEID+YS G P I G +
Sbjct: 345 SVLIGAFSIGQTAPSIEAFANARGAAYAIFNIIDNEPEIDSYSDAGHKPDHIKGNLEFQN 404
Query: 1118 VEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDI 1297
V F YP+R DV+ILKG++L GQTVALVG SGCGKST +QL+QRFY+P G I ID
Sbjct: 405 VFFNYPSRPDVEILKGLNLKVNCGQTVALVGGSGCGKSTTVQLIQRFYDPKEGTITIDGQ 464
Query: 1298 PIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTF 1477
++ N++YLR+++GVV+QEP LF T+I +NIRYGR DV+ E+I RA KEANA DFI
Sbjct: 465 DLKSLNVRYLREIIGVVNQEPVLFATTIAENIRYGREDVTMEEIERATKEANAYDFIMKL 524
Query: 1478 PEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENA 1657
P+ T+VG+RG QMSGGQKQRIAIARALV NPKILLLDEATSALD ESES+VQ+AL+ A
Sbjct: 525 PKKFETVVGERGAQMSGGQKQRIAIARALVHNPKILLLDEATSALDTESESVVQAALDKA 584
Query: 1658 SRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVDD 1837
GRTT+V+AHRLSTVRNAD I V ++G + E G H LIE+KG+Y++LV+ Q D
Sbjct: 585 REGRTTVVVAHRLSTVRNADLIAVFESGVITEQGNHSQLIEKKGIYYKLVNMQTIETEDP 644
Query: 1838 KPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXGA 2017
+K E + R SQ + K ++
Sbjct: 645 SSEKSENAVSVKRSGSQSNLDESLK---KELRRGSTRRSMKKPGEPNDTDEKGSSPDEEL 701
Query: 2018 VKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGH 2197
+ K+++ + EW Y ++ GA+ PAFS+ FS+II +FS D+ +++ +
Sbjct: 702 PPVSFLKLMKLNKNEWPYFVAGTFCAIVNGALQPAFSVIFSEIIGIFSETDQKVLREKSN 761
Query: 2198 FWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGR 2377
++L+FL L + + Q FG A E LTM++R ++ +LRQD +FD PK+S G
Sbjct: 762 LYSLLFLALGIISFFTFFVQGFAFGKAGEILTMKLRFMAFKAMLRQDMAWFDDPKNSTGA 821
Query: 2378 ITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQA 2557
+TTRLA DA +K A RL I IA++G G+ I+ YGWQ+ L++A+ P +AV
Sbjct: 822 LTTRLANDASQVKGATGVRLALIAQNIANLGTGIIISLVYGWQLTLLLLAVVPIIAVAGM 881
Query: 2558 LMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNIS 2737
+ MK G A D E+E AGK A EAIENIRTV +LT + + ++ HL P+ ++
Sbjct: 882 IEMKMLAGHAKKDKIELEAAGKIATEAIENIRTVASLTREKRFELMYGEHLLVPYRNSVK 941
Query: 2738 KAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFA 2917
KA I G + + ++ FFTYA FRFG +L+ + ++ E + V V A+ F +G
Sbjct: 942 KAHIFGFCFSLSQAMMFFTYAGCFRFGAYLVVNGHI--EYKTVFLVFSAVVFGAMALGQT 999
Query: 2918 ASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKLNKVFFRYPERPAVP 3094
+S+ P+Y KA +A +F + P ID G P+ G ++ V F YP RP V
Sbjct: 1000 SSFAPDYAKAKISAAHLFVLFNRVPPIDSYREDGEKPEKFGGNTRIKDVKFNYPNRPEVK 1059
Query: 3095 ILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRK 3274
ILQGLN+ V+ G+TLALVG SGCGKSTV+ LLER YDPL G + D+ D + +N + LR
Sbjct: 1060 ILQGLNLAVEKGETLALVGSSGCGKSTVVQLLERFYDPLSGEIVFDDIDAKTLNIQWLRS 1119
Query: 3275 HIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGE 3454
HI +VSQEPILFD +I ENI YG E +HE+I +A A+IH FID LP+ Y TRVG+
Sbjct: 1120 HIGIVSQEPILFDFTIAENIAYGDNSREVSHEEIISAAKAASIHSFIDSLPEKYNTRVGD 1179
Query: 3455 KGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVA 3634
KGTQLSGGQKQRIAIARALIR P+ILLLDEATSALDTESEK VQ ALD A + RTCIV+A
Sbjct: 1180 KGTQLSGGQKQRIAIARALIRKPQILLLDEATSALDTESEKIVQEALDKAREGRTCIVIA 1239
Query: 3635 HRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSSN 3772
HRLSTI NA I V++NG+V+EQGTH +L+A++G Y++L QS +
Sbjct: 1240 HRLSTIQNADKIAVIQNGKVIEQGTHQQLLAEKGFYYSLVNVQSGS 1285
Score = 381 bits (978), Expect = e-104
Identities = 218/535 (40%), Positives = 312/535 (57%), Gaps = 1/535 (0%)
Frame = +2
Query: 2201 WALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRI 2380
+A + +AA + Q S + +AA R +IR K + ++RQ+ +FD+ + G +
Sbjct: 122 YAYYYSAIAAAVLVAAYIQTSFWTLAAGRQVKKIREKFFHAIMRQEIGWFDV--NDAGEL 179
Query: 2381 TTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQAL 2560
TRL D I I ++G + + + G + F GW++ +++A+ P + + AL
Sbjct: 180 NTRLIDDVSKINEGIGDKIGFLIQSETTFLTGFIVGFIRGWKLTLVILAVSPVLGLSAAL 239
Query: 2561 MMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISK 2740
K + AG A E + +RTV A Q K + +L+ I K
Sbjct: 240 WAKILTAFTDKEQAAYAKAGAVAEEVLSAVRTVIAFGGQEKEIKRYHKNLEDAKRIGIRK 299
Query: 2741 AIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAA 2920
AI ++ G A + + +YA AF +G LI + NVL V F++ +IG A
Sbjct: 300 AITSNISMGAAFLLIYASYALAFWYGTTLILANEYSIG--NVLTVFFSVLIGAFSIGQTA 357
Query: 2921 SYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKLNKVFFRYPERPAVPI 3097
+ A AA IFN+++ EP ID + +G P + G ++ VFF YP RP V I
Sbjct: 358 PSIEAFANARGAAYAIFNIIDNEPEIDSYSDAGHKPDHIKGNLEFQNVFFNYPSRPDVEI 417
Query: 3098 LQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKH 3277
L+GLN+ V GQT+ALVG SGCGKST + L++R YDP EG +T+D DL+ +N ++LR+
Sbjct: 418 LKGLNLKVNCGQTVALVGGSGCGKSTTVQLIQRFYDPKEGTITIDGQDLKSLNVRYLREI 477
Query: 3278 IALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEK 3457
I +V+QEP+LF T+I ENI YG + + T E+IE A +AN + FI +LP +ET VGE+
Sbjct: 478 IGVVNQEPVLFATTIAENIRYGRE--DVTMEEIERATKEANAYDFIMKLPKKFETVVGER 535
Query: 3458 GTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAH 3637
G Q+SGGQKQRIAIARAL+ NPKILLLDEATSALDTESE VQ ALD A + RT +VVAH
Sbjct: 536 GAQMSGGQKQRIAIARALVHNPKILLLDEATSALDTESESVVQAALDKAREGRTTVVVAH 595
Query: 3638 RLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSSNQSGGAFDTSE 3802
RLST+ NA I V ++G + EQG H++LI K+G Y+ L Q+ + + SE
Sbjct: 596 RLSTVRNADLIAVFESGVITEQGNHSQLIEKKGIYYKLVNMQTIETEDPSSEKSE 650
>gi|46394986|gb|AAS91649.1| multidrug resistance protein 1a;
P-glycoprotein [Rattus norvegicus]
Length = 1272
Score = 1072 bits (2772), Expect = 0.0
Identities = 563/1259 (44%), Positives = 792/1259 (62%), Gaps = 17/1259 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+S+ ++RY +DR + +G + + G+ LPLM ++ G+++ +F +G + + +
Sbjct: 33 VSVLTMFRYAGWLDRFYMLLGTLAAIIHGIALPLMMLVFGDMTDSFANVGN---NRSMSF 89
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
A+ E+ Y +G G+ ++Q S + + + ++ R++FFH++M
Sbjct: 90 YNATDIYAKLKDEMTTYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFFHAIMN 149
Query: 401 QEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLI 580
QEI W+D + G L+ +L D++ ++ EG GDK+G+ FQ MA F GGF + FT W LTL+
Sbjct: 150 QEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTLV 209
Query: 581 MMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRY 760
++++SP + + YA AG +AEEVL +IRTVIAF GQ+ E +RY
Sbjct: 210 ILAISPVLGLSAGIWAKILSSFTDKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKELERY 269
Query: 761 EDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFS 940
+ LE K+ GIKK+ + + F++IYASY LAFW GT+ V S G VLTVFFS
Sbjct: 270 NNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYTIGQVLTVFFS 329
Query: 941 VMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKV 1120
V++G+ ++GQA A GAA ++ +ID P ID++S G P I G + +
Sbjct: 330 VLIGAFSVGQASPNIEAFANARGAAYEVFSIIDNKPSIDSFSKSGHKPDNIQGNLEFKNI 389
Query: 1121 EFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIP 1300
F+YP+R DV+ILKG++L + GQTVALVG+SGCGKST +QLLQR Y+P G++ ID
Sbjct: 390 HFSYPSRKDVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEGEVSIDGQD 449
Query: 1301 IEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFP 1480
I N++YLR+++GVVSQEP LF T+I +NIRYGR +V+ ++I +A+KEANA DFI P
Sbjct: 450 IRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLP 509
Query: 1481 EGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENAS 1660
+TLVG+RG Q+SGGQKQRIAIARALVRNPKILLLDEATSALD ESE++VQ+AL+ A
Sbjct: 510 HKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAR 569
Query: 1661 RGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFAD---- 1828
GRTTIVIAHRLSTVRNAD I G ++E G H+ L+ +KG+Y +LV Q +
Sbjct: 570 EGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTAGNEIEL 629
Query: 1829 ----------VDD-KPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXX 1975
+D+ K++ + R+ S RK Q+ ++
Sbjct: 630 GNEACESKDGIDNVDMSSKDSGSSLIRRRSTRKSIRGPHDQDGEL--------------- 674
Query: 1976 XXXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINV 2155
A+ ++IL+ EW Y +I G + PAFS+ FS+++ V
Sbjct: 675 ----STKEALDDDVPPASFWRILKLNSTEWPYFVVGVFCAIINGGLQPAFSIIFSKVVGV 730
Query: 2156 FSNPDRDQM-KKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLR 2332
F+ D ++ +++ + ++L+FL+L + + Q FG A E LT R+R V++++LR
Sbjct: 731 FTKNDTPEIQRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLR 790
Query: 2333 QDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMA 2512
QD ++FD PK++ G +TTRLA DA +K A RL I IA++G G+ I+ YGWQ+
Sbjct: 791 QDISWFDDPKNTTGALTTRLANDAAQVKGATGSRLAVITQNIANLGTGIIISLIYGWQLT 850
Query: 2513 FLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYN 2692
L++AI P +A+ + MK G A D KE+E +GK A EAIEN RTV +LT + K
Sbjct: 851 LLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFET 910
Query: 2693 IFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLR 2872
++ L P+ + KA + G+T+ F ++ +F+YAA FRFG +L+ LM ENVL
Sbjct: 911 MYAQSLQIPYRNALKKAHVFGITFSFTQAMMYFSYAACFRFGAYLV--ARELMTFENVLL 968
Query: 2873 VLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYP-QLSGEVK 3049
V AI F +G +S+ P+Y KA +A I ++E+ P ID ++ G P L G VK
Sbjct: 969 VFSAIVFGAMAVGQVSSFAPDYAKAKVSASHIIRIIEKIPEIDSYSTEGLKPNMLEGNVK 1028
Query: 3050 LNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTV 3229
N V F YP RP +P+LQGL++ K GQTLALVG SGCGKSTV+ LLER YDP+ G V +
Sbjct: 1029 FNGVMFNYPTRPNIPVLQGLSLEGKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFL 1088
Query: 3230 DNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHK 3409
D +++Q+N + LR H+ +VSQEPILFD SI ENI YG +HE+I A +ANIH+
Sbjct: 1089 DGKEIKQLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSHEEIVKAAKEANIHQ 1148
Query: 3410 FIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQV 3589
FID LP+ Y TRVG+KGTQLSGGQKQRIAIARAL+R P ILLLDEATSALDTESEK VQ
Sbjct: 1149 FIDSLPEKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQE 1208
Query: 3590 ALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQS 3766
ALD A + RTCIV+AHRLSTI NA I+V++NGQV E GTH +L+A++G YF++ Q+
Sbjct: 1209 ALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGQVKEHGTHQQLLAQKGIYFSMVSVQA 1267
Score = 415 bits (1066), Expect = e-114
Identities = 224/521 (42%), Positives = 324/521 (61%), Gaps = 4/521 (0%)
Frame = +2
Query: 275 LKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYD--KNTSGTLSN 448
L ++ LG F FLQ F E L+ R R F S++RQ+I+W+D KNT+G L+
Sbjct: 749 LLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDISWFDDPKNTTGALTT 808
Query: 449 KLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXX 628
+L ++ +V+ TG ++ + Q +A G ++ Y W LTL+++++ P + I G+
Sbjct: 809 RLANDAAQVKGATGSRLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEM 868
Query: 629 XXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSF 808
+ +G IA E + + RTV++ ++ Y +L+ + +KK+
Sbjct: 869 KMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNALKKAH 928
Query: 809 LIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQFA 988
+ G + ++Y SY F G V + VL VF +++ G+MA+GQ
Sbjct: 929 VFGITFSFTQAMMYFSYAACFRFGAYLVARELMTFENVLLVFSAIVFGAMAVGQVSSFAP 988
Query: 989 TIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKGV 1168
A +A+ + +I++IPEID+YSTEG P+ + G + N V F YPTR ++ +L+G+
Sbjct: 989 DYAKAKVSASHIIRIIEKIPEIDSYSTEGLKPNMLEGNVKFNGVMFNYPTRPNIPVLQGL 1048
Query: 1169 SLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVV 1348
SL+ + GQT+ALVGSSGCGKST++QLL+RFY+P AG + +D I+ N+++LR +G+V
Sbjct: 1049 SLEGKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEIKQLNVQWLRAHLGIV 1108
Query: 1349 SQEPNLFNTSIEQNIRYGRSD--VSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQM 1522
SQEP LF+ SI +NI YG + VS E+I +A KEAN FI + PE NT VGD+G Q+
Sbjct: 1109 SQEPILFDCSIAENIAYGDNSRVVSHEEIVKAAKEANIHQFIDSLPEKYNTRVGDKGTQL 1168
Query: 1523 SGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLST 1702
SGGQKQRIAIARALVR P ILLLDEATSALD ESE +VQ AL+ A GRT IVIAHRLST
Sbjct: 1169 SGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLST 1228
Query: 1703 VRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFA 1825
++NAD I+V++ GQV E GTH+ L+ QKG+Y +V Q A
Sbjct: 1229 IQNADLIVVIQNGQVKEHGTHQQLLAQKGIYFSMVSVQAGA 1269
Score = 387 bits (994), Expect = e-105
Identities = 231/598 (38%), Positives = 337/598 (55%), Gaps = 17/598 (2%)
Frame = +2
Query: 2027 NLFKILRYARPEWI---YXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQ------ 2179
++ + RYA W+ Y +I G +P L F + + F+N ++
Sbjct: 34 SVLTMFRYAG--WLDRFYMLLGTLAAIIHGIALPLMMLVFGDMTDSFANVGNNRSMSFYN 91
Query: 2180 -------MKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQD 2338
+K + +A + + A Q SL+ +AA R +IR K + ++ Q+
Sbjct: 92 ATDIYAKLKDEMTTYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFFHAIMNQE 151
Query: 2339 ATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFL 2518
+FD+ H G + TRL D I I ++G F A+A+ GG I F GW++ +
Sbjct: 152 IGWFDV--HDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTLV 209
Query: 2519 VMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIF 2698
++AI P + + + K + + AG A E + IRTV A Q K +
Sbjct: 210 ILAISPVLGLSAGIWAKILSSFTDKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKELERY 269
Query: 2699 CSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVL 2878
++L+ I KAI ++ G A + + +YA AF +G L+ K + VL V
Sbjct: 270 NNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYTIG--QVLTVF 327
Query: 2879 FAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKLN 3055
F++ ++G A+ + A AA +F++++ +P ID + SG P + G ++
Sbjct: 328 FSVLIGAFSVGQASPNIEAFANARGAAYEVFSIIDNKPSIDSFSKSGHKPDNIQGNLEFK 387
Query: 3056 KVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDN 3235
+ F YP R V IL+GLN+ VK GQT+ALVG SGCGKST + LL+RLYDP+EG V++D
Sbjct: 388 NIHFSYPSRKDVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEGEVSIDG 447
Query: 3236 NDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFI 3415
D+R +N ++LR+ I +VSQEP+LF T+I ENI YG + T ++IE A +AN + FI
Sbjct: 448 QDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRE--NVTMDEIEKAVKEANAYDFI 505
Query: 3416 DELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVAL 3595
+LP ++T VGE+G QLSGGQKQRIAIARAL+RNPKILLLDEATSALDTESE VQ AL
Sbjct: 506 MKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAAL 565
Query: 3596 DAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSS 3769
D A + RT IV+AHRLST+ NA I G +VEQG H+EL+ ++G YF L Q++
Sbjct: 566 DKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTA 623
>gi|2353264|gb|AAB69423.1| P-glycoprotein [Homo sapiens]
Length = 1279
Score = 1071 bits (2770), Expect = 0.0
Identities = 570/1261 (45%), Positives = 793/1261 (62%), Gaps = 16/1261 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+S+F ++RY++ +D+L + VG + + G GLPLM ++ G ++ F G + ++
Sbjct: 34 VSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNIT 93
Query: 221 SEKAAARAEFSHEVIQNCLKYVY----LGCGIFAAGFLQASCFMVICEKLSNRFRRQFFH 388
+ F + ++ +Y Y +G G+ A ++Q S + + + ++ R+QFFH
Sbjct: 94 NRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFH 153
Query: 389 SVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWL 568
++MRQEI W+D + G L+ +L D++ ++ EG GDK+G+ FQ MA F GF V FT W
Sbjct: 154 AIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWK 213
Query: 569 LTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYE 748
LTL+++++SP + + YA AG +AEEVL +IRTVIAF GQ+ E
Sbjct: 214 LTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKE 273
Query: 749 CKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLT 928
+RY LE K+ GIKK+ + + F++IYASY LAFW GT V SG G VLT
Sbjct: 274 LERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLT 333
Query: 929 VFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRIS 1108
VF SV++G+ ++GQA A GAA ++++ID P ID+YS G P I G +
Sbjct: 334 VF-SVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLE 392
Query: 1109 VNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILI 1288
V F+YP+R +VKILKG++L Q GQTVALVG+SGCGKST +QL+QR Y+P G + +
Sbjct: 393 FRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSV 452
Query: 1289 DDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFI 1468
D I N+++LR+++GVVSQEP LF T+I +NIRYGR +V+ ++I +A+KEANA DFI
Sbjct: 453 DGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFI 512
Query: 1469 KTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSAL 1648
P +TLVG+RG Q+SGGQKQRIAIARALVRNPKILLLDEATSALD ESE++VQ AL
Sbjct: 513 MKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVAL 572
Query: 1649 ENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQV--- 1819
+ A +GRTTIVIAHRLSTVRNAD I G ++E G H+ L+++KG+Y +LV Q
Sbjct: 573 DKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGN 632
Query: 1820 ---FADVDDKPKKK----EAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXX 1978
+ D+ K + E SR + RK S + SQ
Sbjct: 633 EVELENAADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQ--------------D 678
Query: 1979 XXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVF 2158
+ ++I++ EW Y +I G + PAF++ FS+II VF
Sbjct: 679 RKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVF 738
Query: 2159 SNPDRDQMKK-DGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQ 2335
+ D + K+ + + ++L+FL L + + Q FG A E LT R+R V+R++LRQ
Sbjct: 739 TRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQ 798
Query: 2336 DATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAF 2515
D ++FD PK++ G +TTRLA DA +K AI RL I IA++G G+ I+F YGWQ+
Sbjct: 799 DVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTL 858
Query: 2516 LVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNI 2695
L++AI P +A+ + MK G A D KE+E AGK A EAIEN RTV +LT + K ++
Sbjct: 859 LLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTQEQKFEHM 918
Query: 2696 FCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRV 2875
+ L P+ ++ KA I G+T+ F ++ +F+YA FRFG +L+ K LM E+VL V
Sbjct: 919 YAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHK--LMSFEDVLLV 976
Query: 2876 LFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKL 3052
A+ F +G +S+ P+Y KA +A I ++E+ P ID ++ G P L G V
Sbjct: 977 FSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTF 1036
Query: 3053 NKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVD 3232
+V F YP RP +P+LQGL++ VK GQTLALVG SGCGKSTV+ LLER YDPL G V +D
Sbjct: 1037 GEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLD 1096
Query: 3233 NNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKF 3412
+++++N + LR H+ +VSQEPILFD SI ENI YG + E+I A +ANIH F
Sbjct: 1097 GKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAF 1156
Query: 3413 IDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVA 3592
I+ LP+ Y T+VG+KGTQLSGGQKQRIAIARAL+R P ILLLDEATSALDTESEK VQ A
Sbjct: 1157 IESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEA 1216
Query: 3593 LDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSSN 3772
LD A + RTCIV+AHRLSTI NA I+V +NG+V E GTH +L+A++G YF++ Q+
Sbjct: 1217 LDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGT 1276
Query: 3773 Q 3775
+
Sbjct: 1277 K 1277
>gi|2149087|gb|AAB58489.1| multidrug resistance protein-1 [Ovis aries]
Length = 1285
Score = 1068 bits (2763), Expect = 0.0
Identities = 566/1257 (45%), Positives = 794/1257 (63%), Gaps = 12/1257 (0%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFV---TLGTIFLDPN 211
+S F ++RY++ +DRL + +G + + G GLPLM ++ G+++ +F LG I L
Sbjct: 38 VSTFTMFRYSNWLDRLCMVLGTLAAIIHGAGLPLMMLVFGDMTDSFAGAGNLGNITLSNI 97
Query: 212 STASEKAAARAEFSHEVIQNCLKYVY----LGCGIFAAGFLQASCFMVICEKLSNRFRRQ 379
S S R E+ ++ + Y Y +G G+ A ++Q S + + + +R R+Q
Sbjct: 98 SNTS--TIDRTEYGKKLEKEMTTYAYYYSGIGAGVLIAAYIQVSFWCLAAGRQVHRIRKQ 155
Query: 380 FFHSVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTY 559
FFH++M+QEI W+D + G L+ +L +++ ++ EG GDK+G+ FQ MA F GF + FT
Sbjct: 156 FFHAIMQQEIGWFDVHDVGKLNTRLTNDVSKINEGIGDKIGMFFQAMATFFTGFIIGFTT 215
Query: 560 DWLLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQ 739
W LTL+++++ P + + YA AG +AEEVL +I+TVIAF GQ
Sbjct: 216 GWNLTLVILAIIPVLGLSAAIWAKILSSFTDKKLLAYAKAGAVAEEVLAAIKTVIAFGGQ 275
Query: 740 EYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGT 919
+ E +RY LE K+ GIKK+ + + F++IYASY LAFW GT+ V S G
Sbjct: 276 KKELERYNKNLEEAKRIGIKKAITANISMGAAFLLIYASYALAFWYGTSLVLSREYSIGQ 335
Query: 920 VLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISG 1099
VLTVFFSV++G+ ++GQA A GAA ++++ID P ID+YS G P I G
Sbjct: 336 VLTVFFSVLIGAFSIGQASPNIEAFANARGAAYEVFKIIDNKPSIDSYSNTGHKPDNIKG 395
Query: 1100 RISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQ 1279
+ V F YP+R +VKILKG++L GQTVALVG+SGCGKST +QL+QR Y+P G
Sbjct: 396 NLEFRNVHFHYPSRNEVKILKGLNLKVGSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGM 455
Query: 1280 ILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAA 1459
+ ID I N++YLR+++GVVSQEP LF T+I +NIRYGR DV+ ++I +A+KEANA
Sbjct: 456 VSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIQKAVKEANAY 515
Query: 1460 DFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQ 1639
DFI P +TLVG+RG Q+SGGQKQRIAIARALVRNPKILLLDEATSAL ESE++VQ
Sbjct: 516 DFIMKLPNKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALGTESEAVVQ 575
Query: 1640 SALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQV 1819
+AL+ A +GRTTIVIAHRLSTVRNAD I + G ++E G+H+ L+ ++G+Y +LV Q
Sbjct: 576 AALDKARKGRTTIVIAHRLSTVRNADIIAGLDDGVIVEEGSHDELMGKRGIYFKLVTMQT 635
Query: 1820 FADVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQ---VDXXXXXXXXXXXXXXXXXXX 1990
K + E E S + + +Q+S+ +
Sbjct: 636 ------KGNELELENTPGESLS-KTDDLYMSSQDSRSSLIRRKSTRRSIRGSQSQDRKLS 688
Query: 1991 XXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPD 2170
+ ++IL+ EW Y +I GA+ PAFS+ FS+II +F+ D
Sbjct: 689 TEETLDESVPPVSFWRILKLNITEWPYFVVGVFCAIINGALQPAFSVIFSRIIGIFTRND 748
Query: 2171 RDQMKK-DGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATY 2347
D+ K+ + + ++L+FL+L + + Q FG A E LT R+R V+R++LRQD ++
Sbjct: 749 NDETKRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTRRLRYLVFRSMLRQDVSW 808
Query: 2348 FDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMA 2527
FD PK++ G +TTRLA DA +K A+ RL I IA++G G+ I+ YGWQ+ L++A
Sbjct: 809 FDDPKNTTGALTTRLANDAAQVKGAVGSRLAVITQNIANLGTGIIISLIYGWQLTLLLLA 868
Query: 2528 IFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSH 2707
I P +AV + MK G A D KE+E AGK A EAIEN RTV +LT + + ++
Sbjct: 869 IVPIIAVAGVIEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTREERFEYMYAQS 928
Query: 2708 LDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAI 2887
L P+ ++ +A + G+T+ ++ +F+YA FRFG +L+ +ME ++VL V A+
Sbjct: 929 LQVPYRNSLRRAHVFGITFSITQAMMYFSYAGCFRFGAYLV--AQGIMEFQDVLLVFSAV 986
Query: 2888 SFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKLNKVF 3064
F +G +++ P+Y KA +A + N++E+ P ID ++ G P + G V N V
Sbjct: 987 VFGAMAVGQVSTFAPDYAKAKVSAAHVINIIEKIPLIDSYSTEGLKPSTVEGSVAFNDVV 1046
Query: 3065 FRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDL 3244
F YP RP VP+L+GL++ VK GQTLALVG SGCGKSTV+ LLER YDPL G V +D ++
Sbjct: 1047 FNYPTRPDVPVLRGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFIDGKEV 1106
Query: 3245 RQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDEL 3424
+Q+N + LR H+ +VSQEPILFD SI ENI YG + E+IE A +ANIH FI+ L
Sbjct: 1107 KQLNVQWLRAHMGIVSQEPILFDCSIGENIAYGDNSRVVSQEEIEHAAKEANIHSFIEML 1166
Query: 3425 PDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAA 3604
PD Y TRVG+KGTQLSGGQKQRIAIARAL+R P ILLLDEATSALDTESEK VQ ALD A
Sbjct: 1167 PDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKA 1226
Query: 3605 AKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSSNQ 3775
+ RTCIV+AHRLSTI NA I+V +NG++ E GTH +L+A++G YF + Q+ +
Sbjct: 1227 REGRTCIVIAHRLSTIQNADLIVVFQNGRIKEHGTHQQLLAQKGIYFTMVSVQAGTK 1283
>gi|46394982|gb|AAS91647.1| multidrug resistance protein 1;
P-glycoprotein [Canis familiaris]
Length = 1281
Score = 1065 bits (2755), Expect = 0.0
Identities = 566/1256 (45%), Positives = 792/1256 (62%), Gaps = 14/1256 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNST- 217
+S F ++RY++ +DRL + VG + + G LPLM ++ GN++ +F G + N T
Sbjct: 34 VSTFAMFRYSNWLDRLYMLVGTMAAIIHGAALPLMMLVFGNMTDSFANAG---ISRNKTF 90
Query: 218 ---ASEKAAARAE-FSHEVIQNCLKYVY----LGCGIFAAGFLQASCFMVICEKLSNRFR 373
+E + F + + + Y Y +G G+ A ++Q S + + + + R
Sbjct: 91 PVIINESITNNTQHFINHLEEEMTTYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQILKIR 150
Query: 374 RQFFHSVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAF 553
+QFFH++MRQEI W+D + G L+ +L D++ ++ EG GDK+G+ FQ +A F GF V F
Sbjct: 151 KQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSIATFFTGFIVGF 210
Query: 554 TYDWLLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFN 733
T W LTL+++++SP + + YA AG +AEEVL +IRTVIAF
Sbjct: 211 TRGWKLTLVILAISPVLGLSAAIWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFG 270
Query: 734 GQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLES 913
GQ+ E +RY LE K+ GIKK+ + + F++IYASY LAFW GT+ V S
Sbjct: 271 GQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTSLVLSSEYSI 330
Query: 914 GTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKI 1093
G VLTVFFSV++G+ ++GQA A GAA ++++ID P ID+YS G P I
Sbjct: 331 GQVLTVFFSVLIGAFSIGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNI 390
Query: 1094 SGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDA 1273
G + V F+YP+R +VKILKG++L Q GQTVALVG+SGCGKST +QL+QR Y+P
Sbjct: 391 KGNLEFKNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTD 450
Query: 1274 GQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEAN 1453
G + ID I N+++LR++ GVVSQEP LF T+I +NIRYGR +V+ ++I +A+KEAN
Sbjct: 451 GMVCIDGQDIRTINVRHLREITGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEAN 510
Query: 1454 AADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESI 1633
A DFI P +TLVG+RG Q+SGGQKQRIAIARALVRNPKILLLDEATSALD ESE++
Sbjct: 511 AYDFIMKLPNKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAV 570
Query: 1634 VQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHA 1813
VQ AL+ A +GRTTIVIAHRLSTVRNAD I G ++E G H+ L+++KG+Y +LV
Sbjct: 571 VQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTM 630
Query: 1814 QVFA---DVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXX 1984
Q ++++ + ++E + + GS K + ++
Sbjct: 631 QTRGNEIELENATGESKSESDALEMSPKDSGSSLIKRRSTR-------RSIHAPQGQDRK 683
Query: 1985 XXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFS- 2161
+ ++IL+ EW Y +I G + PAFS+ FS+II +F+
Sbjct: 684 LGTKEDLNENVPPVSFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSIIFSRIIGIFTR 743
Query: 2162 NPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDA 2341
+ D + +++ + ++++FLVL + + Q FG A E LT R+R V+R++LRQD
Sbjct: 744 DEDPETKRQNSNMFSVLFLVLGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDV 803
Query: 2342 TYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLV 2521
++FD PK++ G +TTRLA DA +K AI RL I IA++G G+ I+ YGWQ+ L+
Sbjct: 804 SWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISLIYGWQLTLLL 863
Query: 2522 MAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFC 2701
+AI P +A+ + MK G A D KE+E AGK A EAIEN RTV +LT + K ++
Sbjct: 864 LAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTREQKFEYMYA 923
Query: 2702 SHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLF 2881
L P+ ++ KA I G+++ ++ +F+YA FRFG +L+ N M ++VL V
Sbjct: 924 QSLQVPYRNSLRKAHIFGVSFSITQAMMYFSYAGCFRFGAYLV--ANEFMNFQDVLLVFS 981
Query: 2882 AISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKLNK 3058
AI F +G +S+ P+Y KA +A + ++E+ P ID + G P L G V N+
Sbjct: 982 AIVFGAMAVGQVSSFAPDYAKAKVSAAHVIMIIEKSPLIDSYSPHGLKPNTLEGNVTFNE 1041
Query: 3059 VFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNN 3238
V F YP RP +P+LQGL++ VK GQTLALVG SGCGKSTV+ LLER YDPL G+V +D
Sbjct: 1042 VVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGSVLIDGK 1101
Query: 3239 DLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFID 3418
+++ +N + LR H+ +VSQEPILFD SI ENI YG +HE+I A +ANIH FI+
Sbjct: 1102 EIKHLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSHEEIVQAAKEANIHHFIE 1161
Query: 3419 ELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALD 3598
LP+ Y TRVG+KGTQLSGGQKQRIAIARAL+R P ILLLDEATSALDTESEK VQ ALD
Sbjct: 1162 TLPEKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALD 1221
Query: 3599 AAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQS 3766
A + RTCIV+AHRLSTI NA I+V +NG+V E GTH +L+A++G YF++ Q+
Sbjct: 1222 KAREGRTCIVIAHRLSTIQNADLIVVFQNGKVKEHGTHQQLLAQKGIYFSMVSVQA 1277
Score = 408 bits (1049), Expect = e-112
Identities = 238/601 (39%), Positives = 349/601 (57%), Gaps = 6/601 (0%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+S +++ + ST + VGI + G P SII + F T
Sbjct: 697 VSFWRILKLNST-EWPYFVVGIFCAIINGGLQPAFSIIFSRIIGIF------------TR 743
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGI--FAAGFLQASCFMVICEKLSNRFRRQFFHSV 394
E + + S N ++L GI F FLQ F E L+ R R F S+
Sbjct: 744 DEDPETKRQNS-----NMFSVLFLVLGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSM 798
Query: 395 MRQEIAWYD--KNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWL 568
+RQ+++W+D KNT+G L+ +L ++ +V+ G ++ + Q +A G ++ Y W
Sbjct: 799 LRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISLIYGWQ 858
Query: 569 LTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYE 748
LTL+++++ P + I G+ + AG IA E + + RTV++ ++
Sbjct: 859 LTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTREQKF 918
Query: 749 CKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLT 928
Y +L+ + ++K+ + G + ++Y SY F G V + + VL
Sbjct: 919 EYMYAQSLQVPYRNSLRKAHIFGVSFSITQAMMYFSYAGCFRFGAYLVANEFMNFQDVLL 978
Query: 929 VFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRIS 1108
VF +++ G+MA+GQ A +AA + +I++ P ID+YS G P+ + G ++
Sbjct: 979 VFSAIVFGAMAVGQVSSFAPDYAKAKVSAAHVIMIIEKSPLIDSYSPHGLKPNTLEGNVT 1038
Query: 1109 VNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILI 1288
N+V F YPTR D+ +L+G+SL+ + GQT+ALVGSSGCGKST++QLL+RFY+P AG +LI
Sbjct: 1039 FNEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGSVLI 1098
Query: 1289 DDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSD--VSDEDIARALKEANAAD 1462
D I+ N+++LR +G+VSQEP LF+ SI +NI YG + VS E+I +A KEAN
Sbjct: 1099 DGKEIKHLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSHEEIVQAAKEANIHH 1158
Query: 1463 FIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQS 1642
FI+T PE NT VGD+G Q+SGGQKQRIAIARALVR P ILLLDEATSALD ESE +VQ
Sbjct: 1159 FIETLPEKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQE 1218
Query: 1643 ALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVF 1822
AL+ A GRT IVIAHRLST++NAD I+V + G+V E GTH+ L+ QKG+Y +V Q
Sbjct: 1219 ALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGKVKEHGTHQQLLAQKGIYFSMVSVQAG 1278
Query: 1823 A 1825
A
Sbjct: 1279 A 1279
Score = 381 bits (978), Expect = e-104
Identities = 237/625 (37%), Positives = 341/625 (53%), Gaps = 33/625 (5%)
Frame = +2
Query: 2033 FKILRYARPEWI---YXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMK------ 2185
F + RY+ W+ Y +I GA +P L F + + F+N + K
Sbjct: 37 FAMFRYSN--WLDRLYMLVGTMAAIIHGAALPLMMLVFGNMTDSFANAGISRNKTFPVII 94
Query: 2186 ------KDGHF----------WALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVY 2317
HF +A + + A + Q S + +AA R ++IR + +
Sbjct: 95 NESITNNTQHFINHLEEEMTTYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQILKIRKQFF 154
Query: 2318 RNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYY 2497
++RQ+ +FD+ H G + TRL D I I ++G F +IA+ G + F
Sbjct: 155 HAIMRQEIGWFDV--HDVGELNTRLTDDVSKINEGIGDKIGMFFQSIATFFTGFIVGFTR 212
Query: 2498 GWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQ 2677
GW++ +++AI P + + A+ K + AG A E + IRTV A Q
Sbjct: 213 GWKLTLVILAISPVLGLSAAIWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQ 272
Query: 2678 TKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEP 2857
K + +L+ I KAI ++ G A + + +YA AF +G L+ +
Sbjct: 273 KKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTSLVLSSEYSIG- 331
Query: 2858 ENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-L 3034
VL V F++ +IG A+ + A AA IF +++ +P ID + SG P +
Sbjct: 332 -QVLTVFFSVLIGAFSIGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNI 390
Query: 3035 SGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLE 3214
G ++ V F YP R V IL+GLN+ V+ GQT+ALVG SGCGKST + L++RLYDP +
Sbjct: 391 KGNLEFKNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTD 450
Query: 3215 GAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSK 3394
G V +D D+R +N +HLR+ +VSQEP+LF T+I ENI YG + T ++IE A +
Sbjct: 451 GMVCIDGQDIRTINVRHLREITGVVSQEPVLFATTIAENIRYGRE--NVTMDEIEKAVKE 508
Query: 3395 ANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESE 3574
AN + FI +LP+ ++T VGE+G QLSGGQKQRIAIARAL+RNPKILLLDEATSALDTESE
Sbjct: 509 ANAYDFIMKLPNKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESE 568
Query: 3575 KQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALT 3754
VQVALD A K RT IV+AHRLST+ NA I +G +VE+G H+EL+ ++G YF L
Sbjct: 569 AVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLV 628
Query: 3755 QKQS-------SNQSGGAFDTSEAL 3808
Q+ N +G + S+AL
Sbjct: 629 TMQTRGNEIELENATGESKSESDAL 653
>gi|8926217|gb|AAF81747.1| his-tagged-multidrug resistance
glycoprotein MDR1 [synthetic construct]
Length = 1287
Score = 1065 bits (2754), Expect = 0.0
Identities = 566/1256 (45%), Positives = 792/1256 (62%), Gaps = 14/1256 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNST- 217
+S F ++RY++ +DRL + VG + + G LPLM ++ GN++ +F G + N T
Sbjct: 40 VSTFAMFRYSNWLDRLYMLVGTMAAIIHGAALPLMMLVFGNMTDSFANAG---ISRNKTF 96
Query: 218 ---ASEKAAARAE-FSHEVIQNCLKYVY----LGCGIFAAGFLQASCFMVICEKLSNRFR 373
+E + F + + + Y Y +G G+ A ++Q S + + + + R
Sbjct: 97 PVIINESITNNTQHFINHLEEEMTTYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQILKIR 156
Query: 374 RQFFHSVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAF 553
+QFFH++MRQEI W+D + G L+ +L D++ ++ EG GDK+G+ FQ +A F GF V F
Sbjct: 157 KQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSIATFFTGFIVGF 216
Query: 554 TYDWLLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFN 733
T W LTL+++++SP + + YA AG +AEEVL +IRTVIAF
Sbjct: 217 TRGWKLTLVILAISPVLGLSAAIWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFG 276
Query: 734 GQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLES 913
GQ+ E +RY LE K+ GIKK+ + + F++IYASY LAFW GT+ V S
Sbjct: 277 GQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTSLVLSSEYSI 336
Query: 914 GTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKI 1093
G VLTVFFSV++G+ ++GQA A GAA ++++ID P ID+YS G P I
Sbjct: 337 GQVLTVFFSVLIGAFSIGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNI 396
Query: 1094 SGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDA 1273
G + V F+YP+R +VKILKG++L Q GQTVALVG+SGCGKST +QL+QR Y+P
Sbjct: 397 KGNLEFKNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTD 456
Query: 1274 GQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEAN 1453
G + ID I N+++LR++ GVVSQEP LF T+I +NIRYGR +V+ ++I +A+KEAN
Sbjct: 457 GMVCIDGQDIRTINVRHLREITGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEAN 516
Query: 1454 AADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESI 1633
A DFI P +TLVG+RG Q+SGGQKQRIAIARALVRNPKILLLDEATSALD ESE++
Sbjct: 517 AYDFIMKLPNKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAV 576
Query: 1634 VQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHA 1813
VQ AL+ A +GRTTIVIAHRLSTVRNAD I G ++E G H+ L+++KG+Y +LV
Sbjct: 577 VQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTM 636
Query: 1814 QVFA---DVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXX 1984
Q ++++ + ++E + + GS K + ++
Sbjct: 637 QTRGNEIELENATGESKSESDALEMSPKDSGSSLIKRRSTR-------RSIHAPQGQDRK 689
Query: 1985 XXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFS- 2161
+ ++IL+ EW Y +I G + PAFS+ FS+II +F+
Sbjct: 690 LGTKEDLNENVPPVSFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSIIFSRIIGIFTR 749
Query: 2162 NPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDA 2341
+ D + +++ + ++++FLVL + + Q FG A E LT R+R V+R++LRQD
Sbjct: 750 DEDPETKRQNSNMFSVLFLVLGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDV 809
Query: 2342 TYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLV 2521
++FD PK++ G +TTRLA DA +K AI RL I IA++G G+ I+ YGWQ+ L+
Sbjct: 810 SWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISLIYGWQLTLLL 869
Query: 2522 MAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFC 2701
+AI P +A+ + MK G A D KE+E AGK A EAIEN RTV +LT + K ++
Sbjct: 870 LAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTREQKFEYMYA 929
Query: 2702 SHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLF 2881
L P+ ++ KA I G+++ ++ +F+YA FRFG +L+ N M ++VL V
Sbjct: 930 QSLQVPYRNSLRKAHIFGVSFSITQAMMYFSYAGCFRFGAYLV--ANEFMNFQDVLLVFS 987
Query: 2882 AISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKLNK 3058
AI F +G +S+ P+Y KA +A + ++E+ P ID + G P L G V N+
Sbjct: 988 AIVFGAMAVGQVSSFAPDYAKAKVSAAHVIMIIEKSPLIDSYSPHGLKPNTLEGNVTFNE 1047
Query: 3059 VFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNN 3238
V F YP RP +P+LQGL++ VK GQTLALVG SGCGKSTV+ LLER YDPL G+V +D
Sbjct: 1048 VVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGSVLIDGK 1107
Query: 3239 DLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFID 3418
+++ +N + LR H+ +VSQEPILFD SI ENI YG +HE+I A +ANIH FI+
Sbjct: 1108 EIKHLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSHEEIMQAAKEANIHHFIE 1167
Query: 3419 ELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALD 3598
LP+ Y TRVG+KGTQLSGGQKQRIAIARAL+R P ILLLDEATSALDTESEK VQ ALD
Sbjct: 1168 TLPEKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALD 1227
Query: 3599 AAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQS 3766
A + RTCIV+AHRLSTI NA I+V +NG+V E GTH +L+A++G YF++ Q+
Sbjct: 1228 KAREGRTCIVIAHRLSTIQNADLIVVFQNGKVKEHGTHQQLLAQKGIYFSMISVQA 1283
Score = 407 bits (1047), Expect = e-112
Identities = 237/601 (39%), Positives = 349/601 (57%), Gaps = 6/601 (0%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+S +++ + ST + VGI + G P SII + F T
Sbjct: 703 VSFWRILKLNST-EWPYFVVGIFCAIINGGLQPAFSIIFSRIIGIF------------TR 749
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGI--FAAGFLQASCFMVICEKLSNRFRRQFFHSV 394
E + + S N ++L GI F FLQ F E L+ R R F S+
Sbjct: 750 DEDPETKRQNS-----NMFSVLFLVLGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSM 804
Query: 395 MRQEIAWYD--KNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWL 568
+RQ+++W+D KNT+G L+ +L ++ +V+ G ++ + Q +A G ++ Y W
Sbjct: 805 LRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISLIYGWQ 864
Query: 569 LTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYE 748
LTL+++++ P + I G+ + AG IA E + + RTV++ ++
Sbjct: 865 LTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTREQKF 924
Query: 749 CKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLT 928
Y +L+ + ++K+ + G + ++Y SY F G V + + VL
Sbjct: 925 EYMYAQSLQVPYRNSLRKAHIFGVSFSITQAMMYFSYAGCFRFGAYLVANEFMNFQDVLL 984
Query: 929 VFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRIS 1108
VF +++ G+MA+GQ A +AA + +I++ P ID+YS G P+ + G ++
Sbjct: 985 VFSAIVFGAMAVGQVSSFAPDYAKAKVSAAHVIMIIEKSPLIDSYSPHGLKPNTLEGNVT 1044
Query: 1109 VNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILI 1288
N+V F YPTR D+ +L+G+SL+ + GQT+ALVGSSGCGKST++QLL+RFY+P AG +LI
Sbjct: 1045 FNEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGSVLI 1104
Query: 1289 DDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSD--VSDEDIARALKEANAAD 1462
D I+ N+++LR +G+VSQEP LF+ SI +NI YG + VS E+I +A KEAN
Sbjct: 1105 DGKEIKHLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSHEEIMQAAKEANIHH 1164
Query: 1463 FIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQS 1642
FI+T PE NT VGD+G Q+SGGQKQRIAIARALVR P ILLLDEATSALD ESE +VQ
Sbjct: 1165 FIETLPEKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQE 1224
Query: 1643 ALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVF 1822
AL+ A GRT IVIAHRLST++NAD I+V + G+V E GTH+ L+ QKG+Y ++ Q
Sbjct: 1225 ALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGKVKEHGTHQQLLAQKGIYFSMISVQAG 1284
Query: 1823 A 1825
A
Sbjct: 1285 A 1285
Score = 381 bits (978), Expect = e-104
Identities = 237/625 (37%), Positives = 341/625 (53%), Gaps = 33/625 (5%)
Frame = +2
Query: 2033 FKILRYARPEWI---YXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMK------ 2185
F + RY+ W+ Y +I GA +P L F + + F+N + K
Sbjct: 43 FAMFRYSN--WLDRLYMLVGTMAAIIHGAALPLMMLVFGNMTDSFANAGISRNKTFPVII 100
Query: 2186 ------KDGHF----------WALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVY 2317
HF +A + + A + Q S + +AA R ++IR + +
Sbjct: 101 NESITNNTQHFINHLEEEMTTYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQILKIRKQFF 160
Query: 2318 RNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYY 2497
++RQ+ +FD+ H G + TRL D I I ++G F +IA+ G + F
Sbjct: 161 HAIMRQEIGWFDV--HDVGELNTRLTDDVSKINEGIGDKIGMFFQSIATFFTGFIVGFTR 218
Query: 2498 GWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQ 2677
GW++ +++AI P + + A+ K + AG A E + IRTV A Q
Sbjct: 219 GWKLTLVILAISPVLGLSAAIWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQ 278
Query: 2678 TKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEP 2857
K + +L+ I KAI ++ G A + + +YA AF +G L+ +
Sbjct: 279 KKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTSLVLSSEYSIG- 337
Query: 2858 ENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-L 3034
VL V F++ +IG A+ + A AA IF +++ +P ID + SG P +
Sbjct: 338 -QVLTVFFSVLIGAFSIGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNI 396
Query: 3035 SGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLE 3214
G ++ V F YP R V IL+GLN+ V+ GQT+ALVG SGCGKST + L++RLYDP +
Sbjct: 397 KGNLEFKNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTD 456
Query: 3215 GAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSK 3394
G V +D D+R +N +HLR+ +VSQEP+LF T+I ENI YG + T ++IE A +
Sbjct: 457 GMVCIDGQDIRTINVRHLREITGVVSQEPVLFATTIAENIRYGRE--NVTMDEIEKAVKE 514
Query: 3395 ANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESE 3574
AN + FI +LP+ ++T VGE+G QLSGGQKQRIAIARAL+RNPKILLLDEATSALDTESE
Sbjct: 515 ANAYDFIMKLPNKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESE 574
Query: 3575 KQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALT 3754
VQVALD A K RT IV+AHRLST+ NA I +G +VE+G H+EL+ ++G YF L
Sbjct: 575 AVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLV 634
Query: 3755 QKQS-------SNQSGGAFDTSEAL 3808
Q+ N +G + S+AL
Sbjct: 635 TMQTRGNEIELENATGESKSESDAL 659
>gi|2852441|gb|AAC02113.1| multidrug resistance p-glycoprotein [Canis
familiaris]
Length = 1280
Score = 1063 bits (2750), Expect = 0.0
Identities = 566/1256 (45%), Positives = 792/1256 (62%), Gaps = 14/1256 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNST- 217
+S F ++RY++ +DRL + VG + + G LPLM ++ GN++ +F G + N T
Sbjct: 33 VSTFAMFRYSNWLDRLYMLVGTMAAIIHGAALPLMMLVFGNMTDSFANAG---ISRNKTF 89
Query: 218 ---ASEKAAARAE-FSHEVIQNCLKYVY----LGCGIFAAGFLQASCFMVICEKLSNRFR 373
+E + F + + + Y Y +G G+ A ++Q S + + + + R
Sbjct: 90 PVIINESITNNTQHFINHLEEEMTTYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQILKIR 149
Query: 374 RQFFHSVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAF 553
+QFFH++MRQEI W+D + G L+ +L D++ ++ EG GDKVG+ FQ +A F GF V F
Sbjct: 150 KQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKVGMFFQSIATFFTGFIVGF 209
Query: 554 TYDWLLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFN 733
T W LTL+++++SP + + YA AG +AEEVL +IRTVIAF
Sbjct: 210 TPGWKLTLVILAISPVLGLSAAIWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFG 269
Query: 734 GQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLES 913
GQ+ E +RY LE K+ GIKK+ + + F++IYASY LAFW GT+ V S
Sbjct: 270 GQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTSLVLSSEYTI 329
Query: 914 GTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKI 1093
G VLTVFFSV++G+ ++GQA A GAA ++++ID P ID+YS G P I
Sbjct: 330 GQVLTVFFSVLIGAFSIGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNI 389
Query: 1094 SGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDA 1273
G + V F+YP+R +VKILKG++L Q GQTVALVG+SGCGKST +QL+QR Y+P
Sbjct: 390 KGNLEFKNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTD 449
Query: 1274 GQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEAN 1453
G + ID I N+++LR++ GVVSQEP LF T+I +NIRYGR +V+ ++I +A+KEAN
Sbjct: 450 GMVCIDGQDIRTINVRHLREITGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEAN 509
Query: 1454 AADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESI 1633
A DFI P +TLVG+RG ++SGGQKQRIAIARALVRNPKILLLDEATSALD ESE++
Sbjct: 510 AYDFIMKLPNKFDTLVGERGARLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAV 569
Query: 1634 VQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHA 1813
VQ AL+ A +GRTTIVIAHRLSTVRNAD I G ++E G H+ L+++KG+Y +LV
Sbjct: 570 VQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTM 629
Query: 1814 QVFA---DVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXX 1984
Q ++++ + ++E + + GS K + ++
Sbjct: 630 QTRGNEIELENATGESKSESDALEMSPKDSGSSLIKRRSTR-------RSIHAPQGQDRK 682
Query: 1985 XXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFS- 2161
+ ++IL+ EW Y +I G + PAFS+ FS+II +F+
Sbjct: 683 LGTKEDLNENVPSVSFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSIIFSRIIGIFTR 742
Query: 2162 NPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDA 2341
+ D + +++ + ++++FLVL + + Q FG A E LT R+R V+R++LRQD
Sbjct: 743 DEDPETKRQNSNMFSVLFLVLGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDV 802
Query: 2342 TYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLV 2521
++FD PK++ G +TTRLA DA +K AI RL I IA++G G+ I+ YGWQ+ L+
Sbjct: 803 SWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISLIYGWQLTLLL 862
Query: 2522 MAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFC 2701
+AI P +A+ + MK G A D KE+E AGK A EAIEN RTV +LT + K ++
Sbjct: 863 LAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTREQKFEYMYA 922
Query: 2702 SHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLF 2881
L P+ ++ KA I G+++ ++ +F+YA FRFG +L+ N M ++VL V
Sbjct: 923 QSLQVPYRNSLRKAHIFGVSFSITQAMMYFSYAGCFRFGAYLV--ANEFMNFQDVLLVFS 980
Query: 2882 AISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKLNK 3058
AI F +G +S+ P+Y KA +A + ++E+ P ID + G P L G V N+
Sbjct: 981 AIVFGAMAVGQVSSFAPDYAKAKVSAAHVIMIIEKSPLIDSYSPHGLKPNTLEGNVTFNE 1040
Query: 3059 VFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNN 3238
V F YP RP +P+LQGL++ VK GQTLALVG SGCGKSTV+ LLER YDPL G+V +D
Sbjct: 1041 VVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGSVLIDGK 1100
Query: 3239 DLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFID 3418
+++ +N + LR H+ +VSQEPILFD SI ENI YG +HE+I A +ANIH FI+
Sbjct: 1101 EIKHLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSHEEIMQAAKEANIHHFIE 1160
Query: 3419 ELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALD 3598
LP+ Y TRVG+KGTQLSGGQKQRIAIARAL+R P ILLLDEATSALDTESEK VQ ALD
Sbjct: 1161 TLPEKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALD 1220
Query: 3599 AAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQS 3766
A + RTCIV+AHRLSTI NA I+V +NG+V E GTH +L+A++G YF++ Q+
Sbjct: 1221 KAREGRTCIVIAHRLSTIQNADLIVVFQNGKVKEHGTHQQLLAQKGIYFSMISVQA 1276
Score = 407 bits (1047), Expect = e-112
Identities = 237/601 (39%), Positives = 349/601 (57%), Gaps = 6/601 (0%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+S +++ + ST + VGI + G P SII + F T
Sbjct: 696 VSFWRILKLNST-EWPYFVVGIFCAIINGGLQPAFSIIFSRIIGIF------------TR 742
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGI--FAAGFLQASCFMVICEKLSNRFRRQFFHSV 394
E + + S N ++L GI F FLQ F E L+ R R F S+
Sbjct: 743 DEDPETKRQNS-----NMFSVLFLVLGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSM 797
Query: 395 MRQEIAWYD--KNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWL 568
+RQ+++W+D KNT+G L+ +L ++ +V+ G ++ + Q +A G ++ Y W
Sbjct: 798 LRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISLIYGWQ 857
Query: 569 LTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYE 748
LTL+++++ P + I G+ + AG IA E + + RTV++ ++
Sbjct: 858 LTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTREQKF 917
Query: 749 CKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLT 928
Y +L+ + ++K+ + G + ++Y SY F G V + + VL
Sbjct: 918 EYMYAQSLQVPYRNSLRKAHIFGVSFSITQAMMYFSYAGCFRFGAYLVANEFMNFQDVLL 977
Query: 929 VFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRIS 1108
VF +++ G+MA+GQ A +AA + +I++ P ID+YS G P+ + G ++
Sbjct: 978 VFSAIVFGAMAVGQVSSFAPDYAKAKVSAAHVIMIIEKSPLIDSYSPHGLKPNTLEGNVT 1037
Query: 1109 VNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILI 1288
N+V F YPTR D+ +L+G+SL+ + GQT+ALVGSSGCGKST++QLL+RFY+P AG +LI
Sbjct: 1038 FNEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGSVLI 1097
Query: 1289 DDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSD--VSDEDIARALKEANAAD 1462
D I+ N+++LR +G+VSQEP LF+ SI +NI YG + VS E+I +A KEAN
Sbjct: 1098 DGKEIKHLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSHEEIMQAAKEANIHH 1157
Query: 1463 FIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQS 1642
FI+T PE NT VGD+G Q+SGGQKQRIAIARALVR P ILLLDEATSALD ESE +VQ
Sbjct: 1158 FIETLPEKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQE 1217
Query: 1643 ALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVF 1822
AL+ A GRT IVIAHRLST++NAD I+V + G+V E GTH+ L+ QKG+Y ++ Q
Sbjct: 1218 ALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGKVKEHGTHQQLLAQKGIYFSMISVQAG 1277
Query: 1823 A 1825
A
Sbjct: 1278 A 1278
Score = 379 bits (973), Expect = e-103
Identities = 236/625 (37%), Positives = 341/625 (53%), Gaps = 33/625 (5%)
Frame = +2
Query: 2033 FKILRYARPEWI---YXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMK------ 2185
F + RY+ W+ Y +I GA +P L F + + F+N + K
Sbjct: 36 FAMFRYSN--WLDRLYMLVGTMAAIIHGAALPLMMLVFGNMTDSFANAGISRNKTFPVII 93
Query: 2186 ------KDGHF----------WALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVY 2317
HF +A + + A + Q S + +AA R ++IR + +
Sbjct: 94 NESITNNTQHFINHLEEEMTTYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQILKIRKQFF 153
Query: 2318 RNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYY 2497
++RQ+ +FD+ H G + TRL D I I ++G F +IA+ G + F
Sbjct: 154 HAIMRQEIGWFDV--HDVGELNTRLTDDVSKINEGIGDKVGMFFQSIATFFTGFIVGFTP 211
Query: 2498 GWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQ 2677
GW++ +++AI P + + A+ K + AG A E + IRTV A Q
Sbjct: 212 GWKLTLVILAISPVLGLSAAIWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQ 271
Query: 2678 TKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEP 2857
K + +L+ I KAI ++ G A + + +YA AF +G L+ +
Sbjct: 272 KKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTSLVLSSEYTIG- 330
Query: 2858 ENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-L 3034
VL V F++ +IG A+ + A AA IF +++ +P ID + SG P +
Sbjct: 331 -QVLTVFFSVLIGAFSIGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNI 389
Query: 3035 SGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLE 3214
G ++ V F YP R V IL+GLN+ V+ GQT+ALVG SGCGKST + L++RLYDP +
Sbjct: 390 KGNLEFKNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTD 449
Query: 3215 GAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSK 3394
G V +D D+R +N +HLR+ +VSQEP+LF T+I ENI YG + T ++IE A +
Sbjct: 450 GMVCIDGQDIRTINVRHLREITGVVSQEPVLFATTIAENIRYGRE--NVTMDEIEKAVKE 507
Query: 3395 ANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESE 3574
AN + FI +LP+ ++T VGE+G +LSGGQKQRIAIARAL+RNPKILLLDEATSALDTESE
Sbjct: 508 ANAYDFIMKLPNKFDTLVGERGARLSGGQKQRIAIARALVRNPKILLLDEATSALDTESE 567
Query: 3575 KQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALT 3754
VQVALD A K RT IV+AHRLST+ NA I +G +VE+G H+EL+ ++G YF L
Sbjct: 568 AVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLV 627
Query: 3755 QKQS-------SNQSGGAFDTSEAL 3808
Q+ N +G + S+AL
Sbjct: 628 TMQTRGNEIELENATGESKSESDAL 652
>gi|48267183|gb|AAQ63650.3| multi-drug resistance P-glycoprotein 1;
PGY1; MDR1; GP170; ABC20; P-GP [Oryctolagus cuniculus]
Length = 1279
Score = 1062 bits (2747), Expect = 0.0
Identities = 560/1254 (44%), Positives = 780/1254 (61%), Gaps = 9/1254 (0%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+S F ++RY++ +D+L + VG + + G LPLM ++ G+++ +F G + +
Sbjct: 32 VSAFAMFRYSNWLDKLYMVVGTLAAIIHGAALPLMMLVFGDMTDSFSNPGNMIPANITNL 91
Query: 221 SEKAAARAEFSHEVIQNCLKYVY----LGCGIFAAGFLQASCFMVICEKLSNRFRRQFFH 388
+ + +E + + Y Y +G G+ A ++Q S + + + + + R+QFFH
Sbjct: 92 NMSNISASEIYEHLEEEMTTYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQTFKIRKQFFH 151
Query: 389 SVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWL 568
S+MRQEI W+D + G L+ +L D++ ++ +G GDK+G+ FQ M+ F GF V FT W
Sbjct: 152 SIMRQEIGWFDVHDVGELNTRLTDDVSKINDGIGDKIGMFFQSMSTFFTGFIVGFTRGWK 211
Query: 569 LTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYE 748
LTL+++++SP + + YA AG +AEEVL +IRTVIAF GQ+ E
Sbjct: 212 LTLVILAISPVLGLSAALWAKIMSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQQKE 271
Query: 749 CKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLT 928
+RY LE K+ GIKK+ + F+++YASY LAFW + + G VLT
Sbjct: 272 LERYNKNLEEAKRIGIKKAITANISVGVAFLLMYASYALAFWYWNHLGHLKEYSIGQVLT 331
Query: 929 VFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRIS 1108
VFFSV++G+ ++GQA A GAA ++ +ID +P ID+YS G P I G +
Sbjct: 332 VFFSVLVGAFSIGQASPNVEAFANARGAAYEIFRIIDNMPSIDSYSEAGHKPDNIKGNLE 391
Query: 1109 VNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILI 1288
V F+YP+R +VKILKG++L + GQTVALVG+SGCGKST +QL++R Y+P G + I
Sbjct: 392 FRNVHFSYPSRKEVKILKGLNLKVESGQTVALVGNSGCGKSTTVQLMRRLYDPTDGVVSI 451
Query: 1289 DDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFI 1468
D I N++YLR++ GVVSQEP LF T+I +N+RYGR DV+ ++I +A+KEANA +FI
Sbjct: 452 DGQDIRTMNVRYLREITGVVSQEPVLFATTIAENVRYGREDVTMDEIEKAVKEANAYNFI 511
Query: 1469 KTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSAL 1648
P +TLVG+RG Q+SGGQKQRIAIARALVRNPKILLLDEATSALD ESE++VQ AL
Sbjct: 512 MKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVAL 571
Query: 1649 ENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFAD 1828
+ A +GRTTIVIAHRLSTVRNAD I G ++E G HE L+ QKG+Y LV Q +
Sbjct: 572 DKARKGRTTIVIAHRLSTVRNADVIAGFDNGVIVERGNHEELMRQKGVYFRLVTMQTAGN 631
Query: 1829 VDDKPKKKEAERRMSRQTSQRKGSVNFKTQE---SQVDXXXXXXXXXXXXXXXXXXXXXX 1999
D E S ++ V +E S +
Sbjct: 632 EID------LENSASESRGEKMDLVEMSAKESGSSLIRRRSSHKSFHGAQGQDGKLSTTE 685
Query: 2000 XXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQ 2179
+ ++I++ EW Y +I G + PAF++ FS+I+ VF+ D D+
Sbjct: 686 AQNENVPPVSFWRIMKLNLTEWPYFLVGVICAIINGGLQPAFAVVFSKIVGVFTRNDDDE 745
Query: 2180 MK-KDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDM 2356
K ++ ++L+FL+L + + Q FG A E LT R+R V++++LRQD ++FD
Sbjct: 746 TKRRNSDLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDD 805
Query: 2357 PKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFP 2536
PK++ G +TTRLA DA +K A RL I IA++G G+ I+ YGWQ+ L++AI P
Sbjct: 806 PKNTTGALTTRLANDAAQVKGATGSRLAVIAQNIANLGTGIIISLVYGWQLTLLLLAIVP 865
Query: 2537 FMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDA 2716
+A+ + MK G A D KE+E +GK A EAIEN RTV +LT + K N++ L
Sbjct: 866 IIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFENMYAQSLQV 925
Query: 2717 PHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFS 2896
P+ ++ KA I G+T+ F ++ +F+YA FRFG FL+ LM ENVL V A+ F
Sbjct: 926 PYRNSLEKAHIFGITFSFTQAMMYFSYAGCFRFGAFLV--ARELMSFENVLLVFSAVVFG 983
Query: 2897 FGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYP-QLSGEVKLNKVFFRY 3073
+G +S+ P+Y KA +A I +LE+ P+ID ++ G P L G + V F Y
Sbjct: 984 AMAVGQVSSFAPDYAKAKISASHIIMILEKLPKIDSYSTEGLKPGTLEGNMTFKDVVFNY 1043
Query: 3074 PERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQM 3253
P RP +P+LQGLN+ VK GQTLALVGPSGCGKSTV+ L+ER YDPL G V +D ++ Q+
Sbjct: 1044 PTRPDIPVLQGLNLQVKKGQTLALVGPSGCGKSTVVQLIERFYDPLAGTVLLDGKEVNQL 1103
Query: 3254 NPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDG 3433
N + LR H+ +VSQEPILFD SI ENI YG + ++I A +ANIH FID LPD
Sbjct: 1104 NVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIIKAAKEANIHAFIDSLPDK 1163
Query: 3434 YETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKD 3613
Y TRVG+KGTQLSGGQKQRIAIARAL+R P ILLLDEATSA DTESEK VQ ALD A +
Sbjct: 1164 YNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSAPDTESEKVVQEALDKAREG 1223
Query: 3614 RTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSSNQ 3775
RTC+V+AHRLSTI NA I+V +NG+V E GTH++L+A++G YF++ Q+ +
Sbjct: 1224 RTCVVIAHRLSTIQNADMIVVFQNGRVKECGTHHQLLAQKGIYFSMVSVQAGGK 1277
>gi|22759019|gb|AAN05645.1| multidrug resistance p-glycoprotein [Canis
familiaris]
Length = 1281
Score = 1061 bits (2745), Expect = 0.0
Identities = 563/1258 (44%), Positives = 791/1258 (62%), Gaps = 16/1258 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGT-------IF 199
+S F ++RY++ +DRL + VG + + G LPLM ++ GN++ +F G +
Sbjct: 34 VSTFAMFRYSNWLDRLYMLVGTMAAIIHGAALPLMMLVFGNMTDSFANAGISRNKAFPVI 93
Query: 200 LDPNSTASEKAAARAEFSHEVIQNCLKYVY----LGCGIFAAGFLQASCFMVICEKLSNR 367
++ + T + + F + + + Y Y +G G+ A ++Q S + + + +
Sbjct: 94 INESITNNTQ-----HFINHLEEEMTTYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQILK 148
Query: 368 FRRQFFHSVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAV 547
R+QFFH++MRQEI W+D + G L+ +L D++ ++ EG GDK+G+ F +A F GF V
Sbjct: 149 IRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFHSIATFFTGFIV 208
Query: 548 AFTYDWLLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIA 727
FT W LTL+++++SP + + YA AG +AEEVL +IRTVIA
Sbjct: 209 GFTRGWKLTLVILAISPVLGLSAAIWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIA 268
Query: 728 FNGQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRL 907
F GQ+ E +RY LE K GIKK+ + + F++IYASY LAFW GT+ V S
Sbjct: 269 FGGQKKELERYNKNLEEAKGIGIKKAITANISIGAAFLLIYASYALAFWYGTSLVLSSEY 328
Query: 908 ESGTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPS 1087
G VLTVFFSV++G+ ++GQA A GAA ++++ID P ID+YS G P
Sbjct: 329 SIGQVLTVFFSVLIGAFSIGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPD 388
Query: 1088 KISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNP 1267
I G + V F+YP+R +VKILKG++L Q GQTVALVG+SGCGKST +QL+QR Y+P
Sbjct: 389 NIKGNLEFKNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDP 448
Query: 1268 DAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKE 1447
G + ID I N+++LR++ GVVSQEP LF T+I +NIRYGR +V+ ++I +A+KE
Sbjct: 449 TDGMVCIDGQDIRTINVRHLREITGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKE 508
Query: 1448 ANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESE 1627
ANA DFI P +TLVG+RG Q+SGGQKQRIAIARALVRNPKILLLDEATSALD ESE
Sbjct: 509 ANAYDFIMKLPNKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESE 568
Query: 1628 SIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELV 1807
++VQ AL+ A +GRTTIVIAHRLSTVRNAD I G ++E G H+ L+++KG+Y +LV
Sbjct: 569 AVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLV 628
Query: 1808 HAQVFA---DVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXX 1978
Q ++++ + ++E + + GS K + ++
Sbjct: 629 TMQTRGNEIELENATGESKSESDALEMSPKDSGSSLIKRRSTR-------RSIHAPQGQD 681
Query: 1979 XXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVF 2158
+ ++IL+ EW Y +I G + PAFS+ FS+II +F
Sbjct: 682 RKLGTKEDLNENVPPVSFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSIIFSRIIGIF 741
Query: 2159 S-NPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQ 2335
+ + D + +++ + ++++FLVL + + Q FG A E LT R+R V+R++LRQ
Sbjct: 742 TRDEDPETKRQNSNMFSVLFLVLGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQ 801
Query: 2336 DATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAF 2515
D ++FD PK++ G +TTRLA DA +K AI RL I IA++G G+ I+ YGWQ+
Sbjct: 802 DVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISLIYGWQLTL 861
Query: 2516 LVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNI 2695
L++AI P +A+ + MK G A D KE+E AGK A EAIEN RTV +LT + K +
Sbjct: 862 LLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTREQKFEYM 921
Query: 2696 FCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRV 2875
+ L P+ ++ KA I G+++ ++ +F+YA FRFG +L+ N M ++VL V
Sbjct: 922 YAQSLQVPYRNSLRKAHIFGVSFSITQAMMYFSYAGCFRFGAYLV--ANEFMNFQDVLLV 979
Query: 2876 LFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKL 3052
AI F +G +S+ P+Y KA +A + ++E+ P ID + G P L G V
Sbjct: 980 FSAIVFGAMAVGQVSSFAPDYAKAKVSAAHVIMIIEKSPLIDSYSPHGLKPNTLEGNVTF 1039
Query: 3053 NKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVD 3232
N+V F YP RP +P+LQGL++ VK GQTLALVG SGCGKSTV+ LLER YDPL G+V +D
Sbjct: 1040 NEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGSVLID 1099
Query: 3233 NNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKF 3412
+++ +N + LR H+ +VSQEPILFD SI ENI YG +HE+I A +ANIH F
Sbjct: 1100 GKEIKHLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSHEEIMQAAKEANIHHF 1159
Query: 3413 IDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVA 3592
I+ LP+ Y TRVG+KGTQLSGGQKQRIAIARAL+R P ILLLDEATSALDTESEK VQ A
Sbjct: 1160 IETLPEKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEA 1219
Query: 3593 LDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQS 3766
LD A + RTCIV+AHRLSTI NA I+V +NG+V E GTH +L+A++G YF++ Q+
Sbjct: 1220 LDKAREGRTCIVIAHRLSTIQNADLIVVFQNGKVKEHGTHQQLLAQKGIYFSMVSVQA 1277
Score = 408 bits (1048), Expect = e-112
Identities = 238/601 (39%), Positives = 349/601 (57%), Gaps = 6/601 (0%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+S +++ + ST + VGI + G P SII + F T
Sbjct: 697 VSFWRILKLNST-EWPYFVVGIFCAIINGGLQPAFSIIFSRIIGIF------------TR 743
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGI--FAAGFLQASCFMVICEKLSNRFRRQFFHSV 394
E + + S N ++L GI F FLQ F E L+ R R F S+
Sbjct: 744 DEDPETKRQNS-----NMFSVLFLVLGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSM 798
Query: 395 MRQEIAWYD--KNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWL 568
+RQ+++W+D KNT+G L+ +L ++ +V+ G ++ + Q +A G ++ Y W
Sbjct: 799 LRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISLIYGWQ 858
Query: 569 LTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYE 748
LTL+++++ P + I G+ + AG IA E + + RTV++ ++
Sbjct: 859 LTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTREQKF 918
Query: 749 CKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLT 928
Y +L+ + ++K+ + G + ++Y SY F G V + + VL
Sbjct: 919 EYMYAQSLQVPYRNSLRKAHIFGVSFSITQAMMYFSYAGCFRFGAYLVANEFMNFQDVLL 978
Query: 929 VFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRIS 1108
VF +++ G+MA+GQ A +AA + +I++ P ID+YS G P+ + G ++
Sbjct: 979 VFSAIVFGAMAVGQVSSFAPDYAKAKVSAAHVIMIIEKSPLIDSYSPHGLKPNTLEGNVT 1038
Query: 1109 VNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILI 1288
N+V F YPTR D+ +L+G+SL+ + GQT+ALVGSSGCGKST++QLL+RFY+P AG +LI
Sbjct: 1039 FNEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGSVLI 1098
Query: 1289 DDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSD--VSDEDIARALKEANAAD 1462
D I+ N+++LR +G+VSQEP LF+ SI +NI YG + VS E+I +A KEAN
Sbjct: 1099 DGKEIKHLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSHEEIMQAAKEANIHH 1158
Query: 1463 FIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQS 1642
FI+T PE NT VGD+G Q+SGGQKQRIAIARALVR P ILLLDEATSALD ESE +VQ
Sbjct: 1159 FIETLPEKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQE 1218
Query: 1643 ALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVF 1822
AL+ A GRT IVIAHRLST++NAD I+V + G+V E GTH+ L+ QKG+Y +V Q
Sbjct: 1219 ALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGKVKEHGTHQQLLAQKGIYFSMVSVQAG 1278
Query: 1823 A 1825
A
Sbjct: 1279 A 1279
Score = 384 bits (987), Expect = e-105
Identities = 238/625 (38%), Positives = 343/625 (54%), Gaps = 33/625 (5%)
Frame = +2
Query: 2033 FKILRYARPEWI---YXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMK------ 2185
F + RY+ W+ Y +I GA +P L F + + F+N + K
Sbjct: 37 FAMFRYSN--WLDRLYMLVGTMAAIIHGAALPLMMLVFGNMTDSFANAGISRNKAFPVII 94
Query: 2186 ------KDGHF----------WALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVY 2317
HF +A + + A + Q S + +AA R ++IR + +
Sbjct: 95 NESITNNTQHFINHLEEEMTTYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQILKIRKQFF 154
Query: 2318 RNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYY 2497
++RQ+ +FD+ H G + TRL D I I ++G F++IA+ G + F
Sbjct: 155 HAIMRQEIGWFDV--HDVGELNTRLTDDVSKINEGIGDKIGMFFHSIATFFTGFIVGFTR 212
Query: 2498 GWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQ 2677
GW++ +++AI P + + A+ K + AG A E + IRTV A Q
Sbjct: 213 GWKLTLVILAISPVLGLSAAIWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQ 272
Query: 2678 TKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEP 2857
K + +L+ G I KAI ++ G A + + +YA AF +G L+ +
Sbjct: 273 KKELERYNKNLEEAKGIGIKKAITANISIGAAFLLIYASYALAFWYGTSLVLSSEYSIG- 331
Query: 2858 ENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-L 3034
VL V F++ +IG A+ + A AA IF +++ +P ID + SG P +
Sbjct: 332 -QVLTVFFSVLIGAFSIGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNI 390
Query: 3035 SGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLE 3214
G ++ V F YP R V IL+GLN+ V+ GQT+ALVG SGCGKST + L++RLYDP +
Sbjct: 391 KGNLEFKNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTD 450
Query: 3215 GAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSK 3394
G V +D D+R +N +HLR+ +VSQEP+LF T+I ENI YG + T ++IE A +
Sbjct: 451 GMVCIDGQDIRTINVRHLREITGVVSQEPVLFATTIAENIRYGRE--NVTMDEIEKAVKE 508
Query: 3395 ANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESE 3574
AN + FI +LP+ ++T VGE+G QLSGGQKQRIAIARAL+RNPKILLLDEATSALDTESE
Sbjct: 509 ANAYDFIMKLPNKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESE 568
Query: 3575 KQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALT 3754
VQVALD A K RT IV+AHRLST+ NA I +G +VE+G H+EL+ ++G YF L
Sbjct: 569 AVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLV 628
Query: 3755 QKQS-------SNQSGGAFDTSEAL 3808
Q+ N +G + S+AL
Sbjct: 629 TMQTRGNEIELENATGESKSESDAL 653
>gi|25453370|ref|NP_036755.2| P-glycoprotein/multidrug resistance 1;
ATP-binding cassette, sub-family B (MDR/TAP), member 1
(P-glycoprotein/multidrug resistance 1); ATP-binding
cassette sub-family B (MDR/TAP) member 1
(P-glycoprotein/multidrug resistance 1) [Rattus
norvegicus]
gi|19743730|gb|AAL92458.1| ATP-binding cassette protein B1b [Rattus
norvegicus]
Length = 1275
Score = 1058 bits (2735), Expect = 0.0
Identities = 553/1245 (44%), Positives = 785/1245 (62%), Gaps = 6/1245 (0%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+ IF ++RY +D+L +A+G + + G LPL+ ++ G ++ +F T L +
Sbjct: 32 VGIFGMFRYADWLDKLCMALGTLAAIIHGTLLPLLMLVFGYMTDSFTQAETRILPSVTNQ 91
Query: 221 SEKAAARAEFSHEVIQNCLKYVY----LGCGIFAAGFLQASCFMVICEKLSNRFRRQFFH 388
SE + + + ++ Y Y +G G+ ++Q S + + + ++ R++FFH
Sbjct: 92 SEINSTQTVSDSSLEEDMAMYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFFH 151
Query: 389 SVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWL 568
++M QEI W+D N +G L+ +L D++ ++ +G GDK+G+ FQ + F GF + F W
Sbjct: 152 AIMNQEIGWFDVNDAGELNTRLTDDVSKINDGIGDKLGMFFQSITTFSAGFIIGFISGWK 211
Query: 569 LTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYE 748
LTL+++++SP + + YA AG +AEEVL +IRTVIAF GQ+ E
Sbjct: 212 LTLVILAVSPLIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKE 271
Query: 749 CKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLT 928
+RY LE K+ GIKK+ + ++++YASY LAFW GT+ V S G VLT
Sbjct: 272 LERYNKNLEEAKRVGIKKAITANISIGIAYLLVYASYALAFWYGTSLVLSNEYSIGQVLT 331
Query: 929 VFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRIS 1108
VFFS+++G+ ++G A GAA ++++ID P ID++ST+G P I G +
Sbjct: 332 VFFSILLGTFSIGHLAPNIEAFANARGAAYEIFKIIDNEPSIDSFSTKGHKPDSIMGNLE 391
Query: 1109 VNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILI 1288
V F YP+R++VKILKG++L + GQTVALVG+SGCGKST +QLLQR Y+P G++ I
Sbjct: 392 FKNVYFNYPSRSEVKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEGEVSI 451
Query: 1289 DDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFI 1468
D I N++YLR+++GVVSQEP LF T+I +NIRYGR +V+ ++I +A+KEANA DFI
Sbjct: 452 DGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFI 511
Query: 1469 KTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSAL 1648
P NTLVG+RG Q+SGGQKQRIAIARALVRNPKILLLDEATSALD ESE++VQ+AL
Sbjct: 512 MKLPHKFNTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAAL 571
Query: 1649 ENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFAD 1828
+ A GRTTIVIAHRLSTVRNAD I G ++E G HE L+++KG+Y +LV Q +
Sbjct: 572 DKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEELMKEKGIYFKLVMTQTRGN 631
Query: 1829 VDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXX 2008
+ +P E + S+ + + +S +
Sbjct: 632 -EIEPGNNAYESQSDTGASE----LTSEKSKSPLIRRSIRRSIHRRQDQERRLSSKEDVD 686
Query: 2009 XGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMK- 2185
+ ++IL+ EW Y +I G + P F++ FS+I+ VFS D + K
Sbjct: 687 EDVPMVSFWQILKLNISEWPYLVVGVLCAVINGCIQPVFAIVFSKIVGVFSRDDDHETKQ 746
Query: 2186 KDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKH 2365
++ + ++L+FLV+ + + FQ FG A E LT R+R V++++LRQD ++FD K+
Sbjct: 747 RNCNLFSLLFLVMGMISFVTYFFQGFAFGKAGEILTKRLRYMVFKSMLRQDISWFDDHKN 806
Query: 2366 SPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMA 2545
+ G +TTRLA+DA N+K A+ RL + +A++G G+ ++ YGWQ+ L++ I P +
Sbjct: 807 TTGSLTTRLASDASNVKGAMGSRLAVVTQNVANLGTGIILSLVYGWQLTLLLVVIIPLIV 866
Query: 2546 VGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHG 2725
+G + MK G A D KE+E +GK A EAIEN RTV +LT + K ++ L P+
Sbjct: 867 LGGIIEMKLLSGQALKDKKELEISGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYR 926
Query: 2726 GNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGT 2905
+ KA + G+T+ F ++ +F+YAA FRFG +L+ LM ENV+ V A+ F
Sbjct: 927 NALKKAHVFGITFAFTQAMIYFSYAACFRFGAYLV--ARELMTFENVMLVFSAVVFGAMA 984
Query: 2906 IGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKLNKVFFRYPER 3082
G +S+ P+Y KA +A I ++E+ P ID ++ G P L G VK N V F YP R
Sbjct: 985 AGNTSSFAPDYAKAKVSASHIIRIIEKIPEIDSYSTEGLKPNWLEGNVKFNGVMFNYPTR 1044
Query: 3083 PAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPK 3262
P +P+LQGL+ VK GQTLALVG SGCGKSTV+ LLER Y+P+ G V +D +++Q+N +
Sbjct: 1045 PNIPVLQGLSFEVKKGQTLALVGSSGCGKSTVVQLLERFYNPMAGTVFLDGKEIKQLNVQ 1104
Query: 3263 HLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYET 3442
LR H+ +VSQEPILFD SI ENI YG +HE+I A +ANIH+FID LP+ Y T
Sbjct: 1105 WLRAHLGIVSQEPILFDCSITENIAYGDNSRVVSHEEIVRAAREANIHQFIDSLPEKYNT 1164
Query: 3443 RVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTC 3622
RVG+KGTQLSGGQKQRIAIARAL+R P ILLLDEATSALDTESEK VQ ALD A + RTC
Sbjct: 1165 RVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTC 1224
Query: 3623 IVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQ 3757
IV+AHRLSTI NA I+V++NGQV E GTH +L+A++G YF++ Q
Sbjct: 1225 IVIAHRLSTIQNADLIVVIQNGQVKEHGTHQQLLAQKGIYFSMVQ 1269
Score = 412 bits (1058), Expect = e-113
Identities = 230/582 (39%), Positives = 339/582 (57%), Gaps = 8/582 (1%)
Frame = +2
Query: 92 LAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHEVIQN 271
L VG++ + G P+ +I+ + +G D + ++ N
Sbjct: 708 LVVGVLCAVINGCIQPVFAIVFSKI------VGVFSRDDDHETKQR-------------N 748
Query: 272 C----LKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYD--KNTS 433
C L ++ +G F F Q F E L+ R R F S++RQ+I+W+D KNT+
Sbjct: 749 CNLFSLLFLVMGMISFVTYFFQGFAFGKAGEILTKRLRYMVFKSMLRQDISWFDDHKNTT 808
Query: 434 GTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMIC 613
G+L+ +L + V+ G ++ + Q +A G ++ Y W LTL+++ + P +++
Sbjct: 809 GSLTTRLASDASNVKGAMGSRLAVVTQNVANLGTGIILSLVYGWQLTLLLVVIIPLIVLG 868
Query: 614 GLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTG 793
G+ + ++G IA E + + RTV++ ++ Y +L+ +
Sbjct: 869 GIIEMKLLSGQALKDKKELEISGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNA 928
Query: 794 IKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQA 973
+KK+ + G A +IY SY F G V + V+ VF +V+ G+MA G
Sbjct: 929 LKKAHVFGITFAFTQAMIYFSYAACFRFGAYLVARELMTFENVMLVFSAVVFGAMAAGNT 988
Query: 974 GQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVK 1153
A +A+ + +I++IPEID+YSTEG P+ + G + N V F YPTR ++
Sbjct: 989 SSFAPDYAKAKVSASHIIRIIEKIPEIDSYSTEGLKPNWLEGNVKFNGVMFNYPTRPNIP 1048
Query: 1154 ILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQ 1333
+L+G+S + + GQT+ALVGSSGCGKST++QLL+RFYNP AG + +D I+ N+++LR
Sbjct: 1049 VLQGLSFEVKKGQTLALVGSSGCGKSTVVQLLERFYNPMAGTVFLDGKEIKQLNVQWLRA 1108
Query: 1334 LVGVVSQEPNLFNTSIEQNIRYGRSD--VSDEDIARALKEANAADFIKTFPEGLNTLVGD 1507
+G+VSQEP LF+ SI +NI YG + VS E+I RA +EAN FI + PE NT VGD
Sbjct: 1109 HLGIVSQEPILFDCSITENIAYGDNSRVVSHEEIVRAAREANIHQFIDSLPEKYNTRVGD 1168
Query: 1508 RGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIA 1687
+G Q+SGGQKQRIAIARALVR P ILLLDEATSALD ESE +VQ AL+ A GRT IVIA
Sbjct: 1169 KGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIA 1228
Query: 1688 HRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHA 1813
HRLST++NAD I+V++ GQV E GTH+ L+ QKG+Y +V A
Sbjct: 1229 HRLSTIQNADLIVVIQNGQVKEHGTHQQLLAQKGIYFSMVQA 1270
Score = 383 bits (984), Expect = e-104
Identities = 231/603 (38%), Positives = 330/603 (54%), Gaps = 24/603 (3%)
Frame = +2
Query: 2030 LFKILRYARPEWI---YXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDR--------- 2173
+F + RYA +W+ +I G ++P L F + + F+ +
Sbjct: 34 IFGMFRYA--DWLDKLCMALGTLAAIIHGTLLPLLMLVFGYMTDSFTQAETRILPSVTNQ 91
Query: 2174 -----------DQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYR 2320
+++D +A + + A Q SL+ +AA R +IR K +
Sbjct: 92 SEINSTQTVSDSSLEEDMAMYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFFH 151
Query: 2321 NVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYG 2500
++ Q+ +FD+ + G + TRL D I I +LG F +I + G I F G
Sbjct: 152 AIMNQEIGWFDV--NDAGELNTRLTDDVSKINDGIGDKLGMFFQSITTFSAGFIIGFISG 209
Query: 2501 WQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQT 2680
W++ +++A+ P + + A+ K + + AG A E + IRTV A Q
Sbjct: 210 WKLTLVILAVSPLIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRTVIAFGGQK 269
Query: 2681 KLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPE 2860
K + +L+ I KAI ++ G A + + +YA AF +G L+ +
Sbjct: 270 KELERYNKNLEEAKRVGIKKAITANISIGIAYLLVYASYALAFWYGTSLVLSNEYSIG-- 327
Query: 2861 NVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LS 3037
VL V F+I +IG A + A AA IF +++ EP ID ++ G P +
Sbjct: 328 QVLTVFFSILLGTFSIGHLAPNIEAFANARGAAYEIFKIIDNEPSIDSFSTKGHKPDSIM 387
Query: 3038 GEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEG 3217
G ++ V+F YP R V IL+GLN+ VK GQT+ALVG SGCGKST + LL+RLYDP+EG
Sbjct: 388 GNLEFKNVYFNYPSRSEVKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEG 447
Query: 3218 AVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKA 3397
V++D D+R +N ++LR+ I +VSQEP+LF T+I ENI YG + T ++IE A +A
Sbjct: 448 EVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRE--NVTMDEIEKAVKEA 505
Query: 3398 NIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEK 3577
N + FI +LP + T VGE+G QLSGGQKQRIAIARAL+RNPKILLLDEATSALDTESE
Sbjct: 506 NAYDFIMKLPHKFNTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEA 565
Query: 3578 QVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQ 3757
VQ ALD A + RT IV+AHRLST+ NA I G +VEQG H EL+ ++G YF L
Sbjct: 566 VVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEELMKEKGIYFKLVM 625
Query: 3758 KQS 3766
Q+
Sbjct: 626 TQT 628
>gi|126928|sp|P21449|MDR2_CRIGR Multidrug resistance protein 2
(P-glycoprotein 2)
gi|191167|gb|AAA68884.1| p-glycoprotein isoform II
Length = 1276
Score = 1053 bits (2723), Expect = 0.0
Identities = 557/1245 (44%), Positives = 777/1245 (61%), Gaps = 6/1245 (0%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+ IF ++RY +D+L + +G + + G LPL+ ++ GN++ +F T PN T
Sbjct: 34 VGIFGMFRYADWLDKLYMVLGTLAAVLHGTSLPLLMLVFGNMTDSFTKAETSIW-PNMTN 92
Query: 221 SEKAAARAEFSHEVIQNCLKYVY----LGCGIFAAGFLQASCFMVICEKLSNRFRRQFFH 388
+ S + ++ Y Y +G G+ ++Q S + + + N+ R++FFH
Sbjct: 93 QSEINNTEVISGSLEEDMATYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQINKIRQKFFH 152
Query: 389 SVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWL 568
++M QEI W+D + G L+ +L D++ ++ +G GDK+G+ FQ +A F+ F V F W
Sbjct: 153 AIMNQEIGWFDVHDIGELNTRLTDDVSKINDGIGDKIGMFFQSIATFLAAFIVGFISGWK 212
Query: 569 LTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYE 748
LTL+++++SP + + YA AG +AEEVL +IRTVIAF GQ E
Sbjct: 213 LTLVILAVSPLIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRTVIAFGGQNKE 272
Query: 749 CKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLT 928
+RY LE K GIKK+ + ++++YASY LAFW GT+ V S G VLT
Sbjct: 273 LERYNKNLEEAKNVGIKKAVTANISIGIAYLLVYASYALAFWYGTSLVLSNEYSVGQVLT 332
Query: 929 VFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRIS 1108
VFFS++ G+ ++G A GAA ++++ID P ID++ST+G P + G +
Sbjct: 333 VFFSILFGTFSIGHIAPNIEVFANARGAAYEIFKIIDNEPSIDSFSTQGHKPDSVMGNLE 392
Query: 1109 VNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILI 1288
V F+YP+R+ +KILKG++L Q GQTVALVG SGCGKST +QLLQR Y+P G + I
Sbjct: 393 FKNVHFSYPSRSGIKILKGLNLKVQSGQTVALVGKSGCGKSTTVQLLQRLYDPTEGVVSI 452
Query: 1289 DDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFI 1468
D I N++YLR+++GVVSQEP LF T+I +NIRYGR +V+ ++I +A+KEANA DFI
Sbjct: 453 DGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFI 512
Query: 1469 KTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSAL 1648
P +TLVG+RG Q+SGGQKQRIAIARALVRNPKILLLDEATSALD ESE++VQ+AL
Sbjct: 513 MKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAAL 572
Query: 1649 ENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFAD 1828
+ A GRTTIVIAHRLSTVRNAD I G ++E G HE L+++KG+Y LV Q
Sbjct: 573 DKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEELMKEKGIYCRLVMMQTRG- 631
Query: 1829 VDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXX 2008
++ EA+ S + S FK+ +
Sbjct: 632 -NEVELGSEADGSQSDTIASELTSEEFKSPSVR---KSTCRSICGSQDQERRVSVKEAQD 687
Query: 2009 XGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKK 2188
+ + IL+ EW Y +I G + P FS+ FS II VF+ D + K+
Sbjct: 688 EDVPLVSFWGILKLNITEWPYLVVGVLCAVINGCMQPVFSIVFSGIIGVFTRDDDPKTKQ 747
Query: 2189 DG-HFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKH 2365
+ ++L FLV+ + + FQ FG A E LT R+R V++++LRQD ++FD ++
Sbjct: 748 QNCNLFSLFFLVMGMICFVTYFFQGFTFGKAGEILTKRLRYMVFKSMLRQDISWFDDHRN 807
Query: 2366 SPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMA 2545
S G +TTRLA+DA N+K A+ RL I +A++G G+ I+ YGWQ+ L++ I P +
Sbjct: 808 STGALTTRLASDAANVKGAMSSRLAGITQNVANLGTGIIISLVYGWQLTLLLVVIAPLII 867
Query: 2546 VGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHG 2725
+ + MK G A D KE+E +GK A EAIEN RTV +LT + K N++ L P+
Sbjct: 868 LSGMMEMKVLSGQALKDKKELEVSGKIATEAIENFRTVVSLTREQKFENMYAQSLQIPYR 927
Query: 2726 GNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGT 2905
+ KA + G+T+ F ++ +F+YAA FRFG +L+ + +M ENV+ V A+ F
Sbjct: 928 NALKKAHVFGITFSFTQAMMYFSYAACFRFGAYLV--AHQIMTFENVMLVFSAVVFGAIA 985
Query: 2906 IGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKLNKVFFRYPER 3082
G A+S+ P+Y KA +A I ++E+ P ID ++ G P L G VK N+V F YP R
Sbjct: 986 AGNASSFAPDYAKAKVSASHIIRIMEKIPSIDSYSTRGLKPNWLEGNVKFNEVVFNYPTR 1045
Query: 3083 PAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPK 3262
P +P+LQGL++ VK GQTLALVG SGCGKSTV+ LLER YDP+ G V +D +++Q+N +
Sbjct: 1046 PDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEIKQLNVQ 1105
Query: 3263 HLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYET 3442
LR H+ +VSQEPILFD SI ENI YG + ++IE A +ANIH+FI+ LPD Y T
Sbjct: 1106 WLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIERAAKEANIHQFIESLPDKYNT 1165
Query: 3443 RVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTC 3622
RVG+KGTQLSGGQKQRIAIARAL+R P ILLLDEATSALDTESEK VQ ALD A + RTC
Sbjct: 1166 RVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTC 1225
Query: 3623 IVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQ 3757
IV+AHRLSTI NA I+V++NG+V E GTH +L+A++G YF++ Q
Sbjct: 1226 IVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVQ 1270
Score = 403 bits (1035), Expect = e-110
Identities = 224/582 (38%), Positives = 339/582 (57%), Gaps = 8/582 (1%)
Frame = +2
Query: 92 LAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHEVIQN 271
L VG++ + G P+ SI+ + +G D + + QN
Sbjct: 709 LVVGVLCAVINGCMQPVFSIVFSGI------IGVFTRDDDPKTKQ-------------QN 749
Query: 272 C----LKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYD--KNTS 433
C L ++ +G F F Q F E L+ R R F S++RQ+I+W+D +N++
Sbjct: 750 CNLFSLFFLVMGMICFVTYFFQGFTFGKAGEILTKRLRYMVFKSMLRQDISWFDDHRNST 809
Query: 434 GTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMIC 613
G L+ +L + V+ ++ Q +A G ++ Y W LTL+++ ++P +++
Sbjct: 810 GALTTRLASDAANVKGAMSSRLAGITQNVANLGTGIIISLVYGWQLTLLLVVIAPLIILS 869
Query: 614 GLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTG 793
G+ + V+G IA E + + RTV++ ++ Y +L+ +
Sbjct: 870 GMMEMKVLSGQALKDKKELEVSGKIATEAIENFRTVVSLTREQKFENMYAQSLQIPYRNA 929
Query: 794 IKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQA 973
+KK+ + G + ++Y SY F G V + V+ VF +V+ G++A G A
Sbjct: 930 LKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVAHQIMTFENVMLVFSAVVFGAIAAGNA 989
Query: 974 GQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVK 1153
A +A+ + ++++IP ID+YST G P+ + G + N+V F YPTR D+
Sbjct: 990 SSFAPDYAKAKVSASHIIRIMEKIPSIDSYSTRGLKPNWLEGNVKFNEVVFNYPTRPDIP 1049
Query: 1154 ILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQ 1333
+L+G+SL+ + GQT+ALVGSSGCGKST++QLL+RFY+P AG + +D I+ N+++LR
Sbjct: 1050 VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEIKQLNVQWLRA 1109
Query: 1334 LVGVVSQEPNLFNTSIEQNIRYGRSD--VSDEDIARALKEANAADFIKTFPEGLNTLVGD 1507
+G+VSQEP LF+ SI +NI YG + VS ++I RA KEAN FI++ P+ NT VGD
Sbjct: 1110 HLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIERAAKEANIHQFIESLPDKYNTRVGD 1169
Query: 1508 RGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIA 1687
+G Q+SGGQKQRIAIARALVR P ILLLDEATSALD ESE +VQ AL+ A GRT IVIA
Sbjct: 1170 KGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIA 1229
Query: 1688 HRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHA 1813
HRLST++NAD I+V++ G+V E GTH+ L+ QKG+Y +V A
Sbjct: 1230 HRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVQA 1271
Score = 377 bits (968), Expect = e-102
Identities = 226/602 (37%), Positives = 328/602 (53%), Gaps = 23/602 (3%)
Frame = +2
Query: 2030 LFKILRYARPEWI---YXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRD-------- 2176
+F + RYA +W+ Y ++ G +P L F + + F+ +
Sbjct: 36 IFGMFRYA--DWLDKLYMVLGTLAAVLHGTSLPLLMLVFGNMTDSFTKAETSIWPNMTNQ 93
Query: 2177 -----------QMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRN 2323
+++D +A + + A Q S + +AA R +IR K +
Sbjct: 94 SEINNTEVISGSLEEDMATYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQINKIRQKFFHA 153
Query: 2324 VLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGW 2503
++ Q+ +FD+ H G + TRL D I I ++G F +IA+ + F GW
Sbjct: 154 IMNQEIGWFDV--HDIGELNTRLTDDVSKINDGIGDKIGMFFQSIATFLAAFIVGFISGW 211
Query: 2504 QMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTK 2683
++ +++A+ P + + A+ K + + AG A E + IRTV A Q K
Sbjct: 212 KLTLVILAVSPLIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRTVIAFGGQNK 271
Query: 2684 LYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPEN 2863
+ +L+ I KA+ ++ G A + + +YA AF +G L+ +
Sbjct: 272 ELERYNKNLEEAKNVGIKKAVTANISIGIAYLLVYASYALAFWYGTSLVLSNEYSVG--Q 329
Query: 2864 VLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSG 3040
VL V F+I F +IG A + A AA IF +++ EP ID ++ G P + G
Sbjct: 330 VLTVFFSILFGTFSIGHIAPNIEVFANARGAAYEIFKIIDNEPSIDSFSTQGHKPDSVMG 389
Query: 3041 EVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGA 3220
++ V F YP R + IL+GLN+ V+ GQT+ALVG SGCGKST + LL+RLYDP EG
Sbjct: 390 NLEFKNVHFSYPSRSGIKILKGLNLKVQSGQTVALVGKSGCGKSTTVQLLQRLYDPTEGV 449
Query: 3221 VTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKAN 3400
V++D D+R +N ++LR+ I +VSQEP+LF T+I ENI YG + T ++IE A +AN
Sbjct: 450 VSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRE--NVTMDEIEKAVKEAN 507
Query: 3401 IHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQ 3580
+ FI +LP ++T VGE+G QLSGGQKQRIAIARAL+RNPKILLLDEATSALDTESE
Sbjct: 508 AYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAV 567
Query: 3581 VQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQK 3760
VQ ALD A + RT IV+AHRLST+ NA I G +VEQG H EL+ ++G Y L
Sbjct: 568 VQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEELMKEKGIYCRLVMM 627
Query: 3761 QS 3766
Q+
Sbjct: 628 QT 629
>gi|40644181|emb|CAC86600.1| multidrug resistance protein [Platichthys
flesus]
Length = 1292
Score = 1051 bits (2719), Expect = 0.0
Identities = 556/1243 (44%), Positives = 772/1243 (61%), Gaps = 7/1243 (0%)
Frame = +2
Query: 56 LYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEK-- 229
++R+ ++D M+ G +++ A GV LPLM I+ G+++ + V T + N T
Sbjct: 49 VFRFADSLDIFMILCGTVMAMANGVVLPLMCIVFGDMTDSLVNFPTGEISDNFTVIYPNF 108
Query: 230 --AAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQ 403
+ ++ + + Y +G + A +LQ S + + + R R+ FFH +M+Q
Sbjct: 109 TGLPINSTLQEDMNRYAIYYSIMGATVLVAAYLQVSLWTMAAGRQVKRIRKLFFHRIMQQ 168
Query: 404 EIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIM 583
+I W+D N +G L+ +L D++ +++EG GDK + Q F+ F + FT W LTL++
Sbjct: 169 DIGWFDVNETGELNTRLIDDVYKIQEGIGDKAAMLIQAYTTFLSAFVIGFTKGWKLTLVI 228
Query: 584 MSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYE 763
+++SP + + YA AG +AEEVL +IRTV AF+GQ+ E KRY
Sbjct: 229 LAVSPALGLSAALFSKVLTSFTSKEQAAYAKAGAVAEEVLAAIRTVFAFSGQDREIKRYH 288
Query: 764 DALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSV 943
LE K GIKK+ + F++IY SY LAFW G+ + S G+VLTV F V
Sbjct: 289 KNLEDAKIMGIKKALSANISMGFTFMVIYLSYALAFWYGSTLILSNEYTIGSVLTVLFVV 348
Query: 944 MMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVE 1123
++G+ +GQ+ T +A GAA +Y +ID P ID+YS G P I G I +
Sbjct: 349 LIGAFTMGQSSANIQTFASARGAAHKVYSIIDNNPTIDSYSEAGFKPDSIKGNIEFKNIH 408
Query: 1124 FTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPI 1303
F+YPTR DV+ILK +SL + GQT+ALVGSSGCGKST +QLLQRFY+P G + +D I
Sbjct: 409 FSYPTRPDVQILKNMSLSVKSGQTMALVGSSGCGKSTTVQLLQRFYDPQDGAVFVDGHDI 468
Query: 1304 EDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPE 1483
N++YLR+++GVVSQEP LF T+I +NIRYGR DV+D++I +A KEANA DFI P+
Sbjct: 469 RSLNVRYLREMIGVVSQEPILFATTISENIRYGRLDVTDQEIEQAAKEANAYDFIIKLPD 528
Query: 1484 GLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASR 1663
TLVGDRG QMSGGQKQR+AIARALVRNPKILLLDEATSALDAESE+IVQ+AL+
Sbjct: 529 KFETLVGDRGTQMSGGQKQRVAIARALVRNPKILLLDEATSALDAESETIVQAALDKVRL 588
Query: 1664 GRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVDDKP 1843
GRTTIV+AHRLST+RNAD I + GQV EVGTH L+E+KG+Y LV Q F DV++
Sbjct: 589 GRTTIVVAHRLSTIRNADVIAGFQDGQVAEVGTHSQLMEKKGIYQRLVTTQTFQDVEEA- 647
Query: 1844 KKKEAERRMS-RQTSQRKGSVNFKTQ-ESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXGA 2017
KEAE +S + S S++ T +
Sbjct: 648 --KEAEEELSVDEKSPLADSLSECTPYRRKTTRGSSMSASEGGKEKTESDKDETEEDENV 705
Query: 2018 VKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGH 2197
+ K+LR PEW Y +I GA+ P F++ FS+II VF+ D++ +++
Sbjct: 706 PPVSFLKVLRLNLPEWPYMLVGTVCAIINGAMQPVFAIIFSKIITVFAEKDQELVRQRAT 765
Query: 2198 FWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGR 2377
++LMF V+ V +M Q FG + E LT+++R ++ ++RQD ++FD PK+S G
Sbjct: 766 LFSLMFAVIGGVSFVTMFLQGFCFGKSGEILTLKLRLGAFKAMMRQDLSWFDNPKNSVGA 825
Query: 2378 ITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQA 2557
+TTRLATDA ++ A R+ ++ A++G + I+F YGW++ L++A+ P M + A
Sbjct: 826 LTTRLATDAAQVQGATGVRMATLAQNFANLGTSVIISFIYGWELTLLILAVVPAMVLAGA 885
Query: 2558 LMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNIS 2737
+ MK G A D KE+E AGK + EAIENIRTV +LT + K +++ +L+ P+ +
Sbjct: 886 VEMKLLTGHAVEDKKELEKAGKISTEAIENIRTVASLTREPKFESLYHKNLEVPYKNSTK 945
Query: 2738 KAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFA 2917
KA + G T+ F+ ++ +F YA FRFG +LI + M+ + V V+ A+ + IG A
Sbjct: 946 KAHVYGATFAFSQAMIYFAYAGCFRFGAWLIEEGR--MDVQGVFLVISAVLYGAMAIGEA 1003
Query: 2918 ASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYP-QLSGEVKLNKVFFRYPERPAVP 3094
S+ P Y KA +A + ++ EP ID ++ G P + G V V F YP RP +P
Sbjct: 1004 NSFAPNYAKAKMSASHLMMLMNLEPAIDNLSQEGETPDRFDGNVHFENVRFNYPSRPNLP 1063
Query: 3095 ILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRK 3274
+LQGL++ VK G+TLALVG SGCGKST+I LLER YDP EG+V +DN + +Q+N LR
Sbjct: 1064 VLQGLDLEVKRGETLALVGSSGCGKSTIIQLLERFYDPREGSVVLDNVNTKQLNIHWLRS 1123
Query: 3275 HIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGE 3454
+ +VSQEP LFD ++ +NI YG T ++I A ANIH FI ELP+ Y+T+ G+
Sbjct: 1124 QMGIVSQEPTLFDCTLAQNIAYGDNSRIATMDEIVAAAKAANIHSFIQELPEKYDTQAGD 1183
Query: 3455 KGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVA 3634
KGTQLSGGQKQRIAIARA++RNP +LLLDEATSALDTESEK VQ ALD A+K RTCI+VA
Sbjct: 1184 KGTQLSGGQKQRIAIARAILRNPMLLLLDEATSALDTESEKVVQEALDQASKGRTCIIVA 1243
Query: 3635 HRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQ 3763
HRLSTI NA I V++ G VVEQGTH +L+AKRG Y L Q
Sbjct: 1244 HRLSTIQNADRIAVLQGGVVVEQGTHQQLLAKRGVYHMLVTTQ 1286
Score = 384 bits (986), Expect = e-105
Identities = 219/580 (37%), Positives = 334/580 (56%), Gaps = 4/580 (0%)
Frame = +2
Query: 92 LAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHEVIQN 271
+ VG + + G P+ +II + T+F + + + A FS
Sbjct: 724 MLVGTVCAIINGAMQPVFAIIFSKII-------TVFAEKDQELVRQRATL--FS------ 768
Query: 272 CLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYD--KNTSGTLS 445
L + +G F FLQ CF E L+ + R F ++MRQ+++W+D KN+ G L+
Sbjct: 769 -LMFAVIGGVSFVTMFLQGFCFGKSGEILTLKLRLGAFKAMMRQDLSWFDNPKNSVGALT 827
Query: 446 NKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFX 625
+L + +V+ TG ++ Q A ++F Y W LTL+++++ P M++ G
Sbjct: 828 TRLATDAAQVQGATGVRMATLAQNFANLGTSVIISFIYGWELTLLILAVVPAMVLAGAVE 887
Query: 626 XXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKS 805
+ AG I+ E + +IRTV + + Y LE K KK+
Sbjct: 888 MKLLTGHAVEDKKELEKAGKISTEAIENIRTVASLTREPKFESLYHKNLEVPYKNSTKKA 947
Query: 806 FLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQF 985
+ GA A +IY +Y F G + GR++ V V +V+ G+MA+G+A
Sbjct: 948 HVYGATFAFSQAMIYFAYAGCFRFGAWLIEEGRMDVQGVFLVISAVLYGAMAIGEANSFA 1007
Query: 986 ATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKG 1165
A +A+ L +++ P ID S EG+TP + G + V F YP+R ++ +L+G
Sbjct: 1008 PNYAKAKMSASHLMMLMNLEPAIDNLSQEGETPDRFDGNVHFENVRFNYPSRPNLPVLQG 1067
Query: 1166 VSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGV 1345
+ L+ + G+T+ALVGSSGCGKSTIIQLL+RFY+P G +++D++ + NI +LR +G+
Sbjct: 1068 LDLEVKRGETLALVGSSGCGKSTIIQLLERFYDPREGSVVLDNVNTKQLNIHWLRSQMGI 1127
Query: 1346 VSQEPNLFNTSIEQNIRYGRSD--VSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQ 1519
VSQEP LF+ ++ QNI YG + + ++I A K AN FI+ PE +T GD+G Q
Sbjct: 1128 VSQEPTLFDCTLAQNIAYGDNSRIATMDEIVAAAKAANIHSFIQELPEKYDTQAGDKGTQ 1187
Query: 1520 MSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLS 1699
+SGGQKQRIAIARA++RNP +LLLDEATSALD ESE +VQ AL+ AS+GRT I++AHRLS
Sbjct: 1188 LSGGQKQRIAIARAILRNPMLLLLDEATSALDTESEKVVQEALDQASKGRTCIIVAHRLS 1247
Query: 1700 TVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQV 1819
T++NAD+I V++ G V+E GTH+ L+ ++G+YH LV Q+
Sbjct: 1248 TIQNADRIAVLQGGVVVEQGTHQQLLAKRGVYHMLVTTQM 1287
Score = 372 bits (955), Expect = e-101
Identities = 215/549 (39%), Positives = 318/549 (57%), Gaps = 1/549 (0%)
Frame = +2
Query: 2165 PDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDAT 2344
P +++D + +A+ + ++ A + Q SL+ +AA R RIR + +++QD
Sbjct: 112 PINSTLQEDMNRYAIYYSIMGATVLVAAYLQVSLWTMAAGRQVKRIRKLFFHRIMQQDIG 171
Query: 2345 YFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVM 2524
+FD+ + G + TRL D I+ I + + A + I F GW++ +++
Sbjct: 172 WFDV--NETGELNTRLIDDVYKIQEGIGDKAAMLIQAYTTFLSAFVIGFTKGWKLTLVIL 229
Query: 2525 AIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCS 2704
A+ P + + AL K + + AG A E + IRTV A + Q + +
Sbjct: 230 AVSPALGLSAALFSKVLTSFTSKEQAAYAKAGAVAEEVLAAIRTVFAFSGQDREIKRYHK 289
Query: 2705 HLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFA 2884
+L+ I KA+ ++ GF + + +YA AF +G LI + +VL VLF
Sbjct: 290 NLEDAKIMGIKKALSANISMGFTFMVIYLSYALAFWYGSTLILSNEYTIG--SVLTVLFV 347
Query: 2885 ISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKLNKV 3061
+ T+G +++ + A AA ++++++ P ID + +G P + G ++ +
Sbjct: 348 VLIGAFTMGQSSANIQTFASARGAAHKVYSIIDNNPTIDSYSEAGFKPDSIKGNIEFKNI 407
Query: 3062 FFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNND 3241
F YP RP V IL+ +++ VK GQT+ALVG SGCGKST + LL+R YDP +GAV VD +D
Sbjct: 408 HFSYPTRPDVQILKNMSLSVKSGQTMALVGSSGCGKSTTVQLLQRFYDPQDGAVFVDGHD 467
Query: 3242 LRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDE 3421
+R +N ++LR+ I +VSQEPILF T+I ENI YG + T ++IE A +AN + FI +
Sbjct: 468 IRSLNVRYLREMIGVVSQEPILFATTISENIRYGRL--DVTDQEIEQAAKEANAYDFIIK 525
Query: 3422 LPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDA 3601
LPD +ET VG++GTQ+SGGQKQR+AIARAL+RNPKILLLDEATSALD ESE VQ ALD
Sbjct: 526 LPDKFETLVGDRGTQMSGGQKQRVAIARALVRNPKILLLDEATSALDAESETIVQAALDK 585
Query: 3602 AAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSSNQSG 3781
RT IVVAHRLSTI NA I ++GQV E GTH++L+ K+G Y L Q+
Sbjct: 586 VRLGRTTIVVAHRLSTIRNADVIAGFQDGQVAEVGTHSQLMEKKGIYQRLVTTQTFQDVE 645
Query: 3782 GAFDTSEAL 3808
A + E L
Sbjct: 646 EAKEAEEEL 654
>gi|6755046|ref|NP_035205.1| ATP-binding cassette, sub-family B
(MDR/TAP), member 1B; P glycoprotein 1 [Mus musculus]
gi|126927|sp|P06795|MDR1_MOUSE Multidrug resistance protein 1
(P-glycoprotein 1)
gi|72474|pir||DVMS1 multidrug resistance protein 1 - mouse
gi|387426|gb|AAA79005.1| multidrug resistance protein
Length = 1276
Score = 1051 bits (2717), Expect = 0.0
Identities = 546/1248 (43%), Positives = 777/1248 (61%), Gaps = 9/1248 (0%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLD----- 205
+ +F ++RY +D+L + +G + + G LPL+ ++ GN++ +F L
Sbjct: 33 VGVFGMFRYADWLDKLCMILGTLAAIIHGTLLPLLMLVFGNMTDSFTKAEASILPSITNQ 92
Query: 206 --PNSTASEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQ 379
PNST + + E+ Y +G G+ ++Q S + + + ++ R++
Sbjct: 93 SGPNSTL---IISNSSLEEEMAIYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQK 149
Query: 380 FFHSVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTY 559
FFH++M QEI W+D + G L+ +L D++ ++ +G GDK+G+ FQ + F+ GF + F
Sbjct: 150 FFHAIMNQEIGWFDVHDVGELNTRLTDDVSKINDGIGDKIGMFFQSITTFLAGFIIGFIS 209
Query: 560 DWLLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQ 739
W LTL+++++SP + + YA AG +AEEVL +IRTVIAF GQ
Sbjct: 210 GWKLTLVILAVSPLIGLSSALWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRTVIAFGGQ 269
Query: 740 EYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGT 919
+ E +RY LE K GIKK+ + ++++YASY LAFW GT+ V S G
Sbjct: 270 QKELERYNKNLEEAKNVGIKKAITASISIGIAYLLVYASYALAFWYGTSLVLSNEYSIGE 329
Query: 920 VLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISG 1099
VLTVFFS+++G+ ++G A GAA ++++ID P ID++ST+G P I G
Sbjct: 330 VLTVFFSILLGTFSIGHLAPNIEAFANARGAAFEIFKIIDNEPSIDSFSTKGYKPDSIMG 389
Query: 1100 RISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQ 1279
+ V F YP+R++V+ILKG++L + GQTVALVG+SGCGKST +QL+QR Y+P G
Sbjct: 390 NLEFKNVHFNYPSRSEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLEGV 449
Query: 1280 ILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAA 1459
+ ID I N++YLR+++GVVSQEP LF T+I +NIRYGR DV+ ++I +A+KEANA
Sbjct: 450 VSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAY 509
Query: 1460 DFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQ 1639
DFI P +TLVG+RG Q+SGGQKQRIAIARALVRNPKILLLDEATSALD ESE++VQ
Sbjct: 510 DFIMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQ 569
Query: 1640 SALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQV 1819
+AL+ A GRTTIVIAHRLSTVRNAD I G ++E G H+ L+ +KG+Y +LV Q
Sbjct: 570 AALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQT 629
Query: 1820 FADVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXX 1999
+ + + Q+ + + +S +
Sbjct: 630 RGN-----EIEPGNNAYGSQSDTDASELTSEESKSPLIRRSIYRSVHRKQDQERRLSMKE 684
Query: 2000 XXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQ 2179
+ ++IL EW Y +I G + P F++ FS+I+ VFS D +
Sbjct: 685 AVDEDVPLVSFWRILNLNLSEWPYLLVGVLCAVINGCIQPVFAIVFSRIVGVFSRDDDHE 744
Query: 2180 MKKDG-HFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDM 2356
K+ + ++L FLV+ + + FQ FG A E LT R+R V++++LRQD ++FD
Sbjct: 745 TKRQNCNLFSLFFLVMGLISFVTYFFQGFTFGKAGEILTKRVRYMVFKSMLRQDISWFDD 804
Query: 2357 PKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFP 2536
K+S G +TTRLA+DA ++K A+ RL + +A++G G+ ++ YGWQ+ L++ I P
Sbjct: 805 HKNSTGSLTTRLASDASSVKGAMGARLAVVTQNVANLGTGVILSLVYGWQLTLLLVVIIP 864
Query: 2537 FMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDA 2716
+ +G + MK G A D K++E +GK A EAIEN RT+ +LT + K ++ L
Sbjct: 865 LIVLGGIIEMKLLSGQALKDKKQLEISGKIATEAIENFRTIVSLTREQKFETMYAQSLQV 924
Query: 2717 PHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFS 2896
P+ + KA + G+T+ F ++ +F+YAA FRFG +L+ + LM ENV+ V A+ F
Sbjct: 925 PYRNAMKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVAQQ--LMTFENVMLVFSAVVFG 982
Query: 2897 FGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQL-SGEVKLNKVFFRY 3073
G +S+ P+Y KA +A I ++E+ P ID ++ G P L G VK N V F Y
Sbjct: 983 AMAAGNTSSFAPDYAKAKVSASHIIRIIEKTPEIDSYSTEGLKPTLLEGNVKFNGVQFNY 1042
Query: 3074 PERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQM 3253
P RP +P+LQGL++ VK GQTLALVG SGCGKSTV+ LLER YDP+ G+V +D +++Q+
Sbjct: 1043 PTRPNIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQL 1102
Query: 3254 NPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDG 3433
N + LR H+ +VSQEPILFD SI ENI YG +HE+I A +ANIH+FID LPD
Sbjct: 1103 NVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRAVSHEEIVRAAKEANIHQFIDSLPDK 1162
Query: 3434 YETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKD 3613
Y TRVG+KGTQLSGGQKQRIAIARAL+R P ILLLDEATSALDTESEK VQ ALD A +
Sbjct: 1163 YNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREG 1222
Query: 3614 RTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQ 3757
RTCIV+AHRLSTI NA I+V++NG+V E GTH +L+A++G YF++ Q
Sbjct: 1223 RTCIVIAHRLSTIQNADLIVVIENGKVKEHGTHQQLLAQKGIYFSMVQ 1270
Score = 404 bits (1039), Expect = e-111
Identities = 218/524 (41%), Positives = 322/524 (60%), Gaps = 8/524 (1%)
Frame = +2
Query: 266 QNC----LKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYD--KN 427
QNC L ++ +G F F Q F E L+ R R F S++RQ+I+W+D KN
Sbjct: 748 QNCNLFSLFFLVMGLISFVTYFFQGFTFGKAGEILTKRVRYMVFKSMLRQDISWFDDHKN 807
Query: 428 TSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMM 607
++G+L+ +L + V+ G ++ + Q +A G ++ Y W LTL+++ + P ++
Sbjct: 808 STGSLTTRLASDASSVKGAMGARLAVVTQNVANLGTGVILSLVYGWQLTLLLVVIIPLIV 867
Query: 608 ICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKK 787
+ G+ Q ++G IA E + + RT+++ ++ Y +L+ +
Sbjct: 868 LGGIIEMKLLSGQALKDKKQLEISGKIATEAIENFRTIVSLTREQKFETMYAQSLQVPYR 927
Query: 788 TGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALG 967
+KK+ + G + ++Y SY F G V + V+ VF +V+ G+MA G
Sbjct: 928 NAMKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVAQQLMTFENVMLVFSAVVFGAMAAG 987
Query: 968 QAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRAD 1147
A +A+ + +I++ PEID+YSTEG P+ + G + N V+F YPTR +
Sbjct: 988 NTSSFAPDYAKAKVSASHIIRIIEKTPEIDSYSTEGLKPTLLEGNVKFNGVQFNYPTRPN 1047
Query: 1148 VKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYL 1327
+ +L+G+SL+ + GQT+ALVGSSGCGKST++QLL+RFY+P AG + +D I+ N+++L
Sbjct: 1048 IPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQWL 1107
Query: 1328 RQLVGVVSQEPNLFNTSIEQNIRYGRSD--VSDEDIARALKEANAADFIKTFPEGLNTLV 1501
R +G+VSQEP LF+ SI +NI YG + VS E+I RA KEAN FI + P+ NT V
Sbjct: 1108 RAHLGIVSQEPILFDCSIAENIAYGDNSRAVSHEEIVRAAKEANIHQFIDSLPDKYNTRV 1167
Query: 1502 GDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIV 1681
GD+G Q+SGGQKQRIAIARALVR P ILLLDEATSALD ESE +VQ AL+ A GRT IV
Sbjct: 1168 GDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIV 1227
Query: 1682 IAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHA 1813
IAHRLST++NAD I+V++ G+V E GTH+ L+ QKG+Y +V A
Sbjct: 1228 IAHRLSTIQNADLIVVIENGKVKEHGTHQQLLAQKGIYFSMVQA 1271
Score = 384 bits (986), Expect = e-105
Identities = 231/603 (38%), Positives = 332/603 (54%), Gaps = 24/603 (3%)
Frame = +2
Query: 2030 LFKILRYARPEWI---YXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPD---------- 2170
+F + RYA +W+ +I G ++P L F + + F+ +
Sbjct: 35 VFGMFRYA--DWLDKLCMILGTLAAIIHGTLLPLLMLVFGNMTDSFTKAEASILPSITNQ 92
Query: 2171 ----------RDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYR 2320
++++ +A + + A Q SL+ +AA R +IR K +
Sbjct: 93 SGPNSTLIISNSSLEEEMAIYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFFH 152
Query: 2321 NVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYG 2500
++ Q+ +FD+ H G + TRL D I I ++G F +I + G I F G
Sbjct: 153 AIMNQEIGWFDV--HDVGELNTRLTDDVSKINDGIGDKIGMFFQSITTFLAGFIIGFISG 210
Query: 2501 WQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQT 2680
W++ +++A+ P + + AL K + + AG A E + IRTV A Q
Sbjct: 211 WKLTLVILAVSPLIGLSSALWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRTVIAFGGQQ 270
Query: 2681 KLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPE 2860
K + +L+ I KAI ++ G A + + +YA AF +G L+ +
Sbjct: 271 KELERYNKNLEEAKNVGIKKAITASISIGIAYLLVYASYALAFWYGTSLVLSNEYSIG-- 328
Query: 2861 NVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LS 3037
VL V F+I +IG A + A AA IF +++ EP ID ++ G P +
Sbjct: 329 EVLTVFFSILLGTFSIGHLAPNIEAFANARGAAFEIFKIIDNEPSIDSFSTKGYKPDSIM 388
Query: 3038 GEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEG 3217
G ++ V F YP R V IL+GLN+ VK GQT+ALVG SGCGKST + L++RLYDPLEG
Sbjct: 389 GNLEFKNVHFNYPSRSEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLEG 448
Query: 3218 AVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKA 3397
V++D D+R +N ++LR+ I +VSQEP+LF T+I ENI YG + + T ++IE A +A
Sbjct: 449 VVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRE--DVTMDEIEKAVKEA 506
Query: 3398 NIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEK 3577
N + FI +LP ++T VGE+G QLSGGQKQRIAIARAL+RNPKILLLDEATSALDTESE
Sbjct: 507 NAYDFIMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEA 566
Query: 3578 QVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQ 3757
VQ ALD A + RT IV+AHRLST+ NA I G +VEQG H+EL+ ++G YF L
Sbjct: 567 VVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVM 626
Query: 3758 KQS 3766
Q+
Sbjct: 627 TQT 629
>gi|4505771|ref|NP_000434.1| ATP-binding cassette, subfamily B, member
4 isoform A; P glycoprotein 3/multiple drug resistance 3;
P-glycoprotein-3/multiple drug resistance-3; multiple
drug resistance 3 [Homo sapiens]
gi|126932|sp|P21439|MDR3_HUMAN Multidrug resistance protein 3
(P-glycoprotein 3)
gi|72473|pir||DVHU3 multidrug resistance protein 3 - human
gi|307181|gb|AAA36207.1| P-glycoprotein
Length = 1279
Score = 1048 bits (2711), Expect = 0.0
Identities = 568/1260 (45%), Positives = 789/1260 (62%), Gaps = 14/1260 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
I + L+RY+ D+L +++G I++ A G GLPLM I+ G ++ FV F P + +
Sbjct: 40 IGVLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFS 99
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
E+ + Y LG G+ A ++Q S + + + + R++FFH+++R
Sbjct: 100 LSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILR 159
Query: 401 QEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLI 580
QEI W+D N + L+ +L D++ ++ EG GDKVG+ FQ +A F GF V F W LTL+
Sbjct: 160 QEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLV 219
Query: 581 MMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRY 760
+M++SP + + YA AG +AEE L +IRTVIAF GQ E +RY
Sbjct: 220 IMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERY 279
Query: 761 EDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFS 940
+ LE+ K+ GIKK+ + F++IYASY LAFW G+ V S G +TVFFS
Sbjct: 280 QKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFS 339
Query: 941 VMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKV 1120
+++G+ ++GQA A GAA ++++ID P+ID++S G P I G + N V
Sbjct: 340 ILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDV 399
Query: 1121 EFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIP 1300
F+YP+RA+VKILKG++L Q GQTVALVGSSGCGKST +QL+QR Y+PD G I ID
Sbjct: 400 HFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQD 459
Query: 1301 IEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFP 1480
I +FN+ YLR+++GVVSQEP LF+T+I +NI YGR +V+ ++I +A+KEANA +FI P
Sbjct: 460 IRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLP 519
Query: 1481 EGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENAS 1660
+ +TLVG+RG Q+SGGQKQRIAIARALVRNPKILLLDEATSALD ESE+ VQ+AL+ A
Sbjct: 520 QKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAR 579
Query: 1661 RGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQV------- 1819
GRTTIVIAHRLSTVRNAD I + G ++E G+H L++++G+Y +LV+ Q
Sbjct: 580 EGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQS 639
Query: 1820 --FADVDDKPKKKEA----ERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXX 1981
F D+K + A + R+ R ++Q K N + + +D
Sbjct: 640 EEFELNDEKAATRMAPNGWKSRLFRHSTQ-KNLKNSQMCQKSLD---------------- 682
Query: 1982 XXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFS 2161
+ K+L+ + EW Y + G + PAFS+ FS+II +F
Sbjct: 683 --VETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFG 740
Query: 2162 NPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDA 2341
D ++ + ++L+FL L + + Q FG A E LT R+RS ++ +LRQD
Sbjct: 741 PGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDM 800
Query: 2342 TYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLV 2521
++FD K+S G ++TRLATDA ++ A RL I IA++G G+ I+F YGWQ+ L+
Sbjct: 801 SWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLL 860
Query: 2522 MAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFC 2701
+A+ P +AV + MK G+A D KE+E AGK A EAIENIRTV +LT + K +++
Sbjct: 861 LAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYV 920
Query: 2702 SHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLF 2881
L P+ ++ KA I G+T+ + + +F+YA FRFG +LI N M +V+ V
Sbjct: 921 EKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIV--NGHMRFRDVILVFS 978
Query: 2882 AISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYP-QLSGEVKLNK 3058
AI F +G A+S+ P+Y KA +A +F + E +P ID + G P + G + N+
Sbjct: 979 AIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNE 1038
Query: 3059 VFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNN 3238
V F YP R VP+LQGL++ VK GQTLALVG SGCGKSTV+ LLER YDPL G V +D
Sbjct: 1039 VVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQ 1098
Query: 3239 DLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFID 3418
+ +++N + LR + +VSQEPILFD SI ENI YG + ++I +A ANIH FI+
Sbjct: 1099 EAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIE 1158
Query: 3419 ELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALD 3598
LP YETRVG+KGTQLSGGQKQRIAIARALIR P+ILLLDEATSALDTESEK VQ ALD
Sbjct: 1159 TLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALD 1218
Query: 3599 AAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSSNQS 3778
A + RTCIV+AHRLSTI NA I+V +NG+V E GTH +L+A++G YF++ Q+ Q+
Sbjct: 1219 KAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQN 1278
>gi|191157|gb|AAA37005.1| p-glycoprotein
Length = 1169
Score = 1048 bits (2709), Expect = 0.0
Identities = 546/1165 (46%), Positives = 749/1165 (63%), Gaps = 3/1165 (0%)
Frame = +2
Query: 281 YVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYDKNTSGTLSNKLFD 460
Y +G G+ ++Q S + + + ++ R++FFH++M QEI W+D + G L+ +L D
Sbjct: 8 YTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVGELNTRLTD 67
Query: 461 NLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXXXXXX 640
++ ++ EG GDK+G+ FQ MA F GGF + FT W LTL+++++SP + +
Sbjct: 68 DVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKILS 127
Query: 641 XXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFLIGA 820
YA AG +AEEVL +IRTVIAF GQ+ E +RY + LE K+ GIKK+
Sbjct: 128 SFTDKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEAKRLGIKKAITANI 187
Query: 821 GLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQFATIGT 1000
+ + F++IYASY LAFW GT+ V S G VLTVFF+V++ ++GQA
Sbjct: 188 SMGAAFLLIYASYALAFWYGTSLVISKEYSIGQVLTVFFAVLIAPFSIGQASPNIEAFAN 247
Query: 1001 ALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKGVSLDA 1180
A GAA ++ +ID P ID++S G P I G + + F+YP+R DV+ILKG++L
Sbjct: 248 ARGAAYEIFNIIDNKPSIDSFSKNGYKPDNIKGNLEFKNIHFSYPSRKDVQILKGLNLKV 307
Query: 1181 QPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQEP 1360
Q GQTVALVG+SGCGKST +QLLQR Y+P G + ID I N++YLR+++GVVSQEP
Sbjct: 308 QSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGVVSIDGQDIRTINVRYLREIIGVVSQEP 367
Query: 1361 NLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQ 1540
LF T+I +NIRYGR +V+ ++I +A+KEANA DFI P +TLVG+RG Q+SGGQKQ
Sbjct: 368 VLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQ 427
Query: 1541 RIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLSTVRNADK 1720
RIAIARALVRNPKILLLDEATSALD ESE++VQ+AL+ A GRTTIVIAHRLSTVRNAD
Sbjct: 428 RIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADI 487
Query: 1721 IIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFA-DVDDKPKKKEAERRMSRQTSQRKG 1897
I G ++E G HE L+ +KG+Y +LV Q +++ + E++ + K
Sbjct: 488 IAGFDGGVIVEQGNHEELMREKGIYFKLVMTQTAGNEIELGNEVGESKNEIDNLDMSSKD 547
Query: 1898 SVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXGAVKANLFKILRYARPEWIYXX 2077
S + S + + ++IL+ EW Y
Sbjct: 548 SAS-----SLIRRRSTRRSIRGPHDQDRKLSTKEALDEDVPPISFWRILKLNSSEWPYFV 602
Query: 2078 XXXXXXLIQGAVMPAFSLFFSQIINVFS-NPDRDQMKKDGHFWALMFLVLAAVQGTSMLF 2254
++ GA+ PAFS+ FS+++ VF+ N D + + D + ++L+FL+L + +
Sbjct: 603 VGIFCAIVNGALQPAFSIIFSKVVGVFTRNTDDETKRHDSNLFSLLFLILGVISFITFFL 662
Query: 2255 QCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYR 2434
Q FG A E LT R+R V++++LRQD ++FD PK++ G +TTRLA DA +K A R
Sbjct: 663 QGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDNPKNTTGALTTRLANDAGQVKGATGAR 722
Query: 2435 LGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMEN 2614
L I IA++G G+ I+ YGWQ+ L++AI P +A+ + MK G A D KE+E
Sbjct: 723 LAVITQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEG 782
Query: 2615 AGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFT 2794
+GK A EAIEN RTV +LT + K N++ L P+ + KA + G+T+ F ++ +F+
Sbjct: 783 SGKIATEAIENFRTVVSLTREQKFENMYAQSLQIPYRNALKKAHVFGITFSFTQAMMYFS 842
Query: 2795 YAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFN 2974
YAA FRFG +L+ + LM ENVL V AI F +G +S+ P+Y KA +A I
Sbjct: 843 YAACFRFGAYLVARE--LMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKAKVSASHIIM 900
Query: 2975 MLEEEPRIDGMTSSGTYPQ-LSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVG 3151
++E+ P ID ++ G P L G VK N+V F YP RP +P+LQGLN+ VK GQTLALVG
Sbjct: 901 IIEKVPSIDSYSTGGLKPNTLEGNVKFNEVVFNYPTRPDIPVLQGLNLEVKKGQTLALVG 960
Query: 3152 PSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIREN 3331
SGCGKSTV+ LLER YDP+ G V +D ++ Q+N + LR H+ +VSQEPILFD SI EN
Sbjct: 961 SSGCGKSTVVQLLERFYDPMAGTVFLDGKEVNQLNVQWLRAHLGIVSQEPILFDCSIAEN 1020
Query: 3332 IVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARAL 3511
I YG + ++IE A +ANIH+FI+ LPD Y TRVG+KGTQLSGGQKQRIAIARAL
Sbjct: 1021 IAYGDNSRVVSQDEIERAAKEANIHQFIESLPDKYNTRVGDKGTQLSGGQKQRIAIARAL 1080
Query: 3512 IRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQ 3691
+R P ILLLDEATSALDTESEK VQ ALD A + RTCIV+AHRLSTI NA I+V++NG+
Sbjct: 1081 VRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGK 1140
Query: 3692 VVEQGTHNELIAKRGAYFALTQKQS 3766
V E GTH +L+A++G YF++ Q+
Sbjct: 1141 VKEHGTHQQLLAQKGIYFSMVSVQA 1165
Score = 408 bits (1049), Expect = e-112
Identities = 231/580 (39%), Positives = 339/580 (57%), Gaps = 4/580 (0%)
Frame = +2
Query: 98 VGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHEVIQNCL 277
VGI + G P SII V F N+ K FS L
Sbjct: 603 VGIFCAIVNGALQPAFSIIFSKVVGVFTR--------NTDDETKRHDSNLFS-------L 647
Query: 278 KYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYD--KNTSGTLSNK 451
++ LG F FLQ F E L+ R R F S++RQ+++W+D KNT+G L+ +
Sbjct: 648 LFLILGVISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDNPKNTTGALTTR 707
Query: 452 LFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXXX 631
L ++ +V+ TG ++ + Q +A G ++ Y W LTL+++++ P + I G+
Sbjct: 708 LANDAGQVKGATGARLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMK 767
Query: 632 XXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFL 811
+ +G IA E + + RTV++ ++ Y +L+ + +KK+ +
Sbjct: 768 MLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFENMYAQSLQIPYRNALKKAHV 827
Query: 812 IGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQFAT 991
G + ++Y SY F G V + VL VF +++ G+MA+GQ
Sbjct: 828 FGITFSFTQAMMYFSYAACFRFGAYLVARELMTFENVLLVFSAIVFGAMAVGQVSSFAPD 887
Query: 992 IGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKGVS 1171
A +A+ + +I+++P ID+YST G P+ + G + N+V F YPTR D+ +L+G++
Sbjct: 888 YAKAKVSASHIIMIIEKVPSIDSYSTGGLKPNTLEGNVKFNEVVFNYPTRPDIPVLQGLN 947
Query: 1172 LDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVS 1351
L+ + GQT+ALVGSSGCGKST++QLL+RFY+P AG + +D + N+++LR +G+VS
Sbjct: 948 LEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEVNQLNVQWLRAHLGIVS 1007
Query: 1352 QEPNLFNTSIEQNIRYGRSD--VSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQMS 1525
QEP LF+ SI +NI YG + VS ++I RA KEAN FI++ P+ NT VGD+G Q+S
Sbjct: 1008 QEPILFDCSIAENIAYGDNSRVVSQDEIERAAKEANIHQFIESLPDKYNTRVGDKGTQLS 1067
Query: 1526 GGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLSTV 1705
GGQKQRIAIARALVR P ILLLDEATSALD ESE +VQ AL+ A GRT IVIAHRLST+
Sbjct: 1068 GGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTI 1127
Query: 1706 RNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFA 1825
+NAD I+V++ G+V E GTH+ L+ QKG+Y +V Q A
Sbjct: 1128 QNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQAGA 1167
Score = 379 bits (974), Expect = e-103
Identities = 217/506 (42%), Positives = 304/506 (59%), Gaps = 1/506 (0%)
Frame = +2
Query: 2255 QCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYR 2434
Q S + +AA R +IR K + ++ Q+ +FD+ H G + TRL D I I +
Sbjct: 22 QVSFWCLAAGRQIHKIRQKFFHAIMNQEIGWFDV--HDVGELNTRLTDDVSKINEGIGDK 79
Query: 2435 LGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMEN 2614
+G F A+A+ GG I F GW++ +++AI P + + + K + +
Sbjct: 80 IGMFFQAMATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELQAYAK 139
Query: 2615 AGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFT 2794
AG A E + IRTV A Q K + ++L+ I KAI ++ G A + + +
Sbjct: 140 AGAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYAS 199
Query: 2795 YAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFN 2974
YA AF +G L+ K + VL V FA+ + +IG A+ + A AA IFN
Sbjct: 200 YALAFWYGTSLVISKEYSIG--QVLTVFFAVLIAPFSIGQASPNIEAFANARGAAYEIFN 257
Query: 2975 MLEEEPRIDGMTSSGTYPQ-LSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVG 3151
+++ +P ID + +G P + G ++ + F YP R V IL+GLN+ V+ GQT+ALVG
Sbjct: 258 IIDNKPSIDSFSKNGYKPDNIKGNLEFKNIHFSYPSRKDVQILKGLNLKVQSGQTVALVG 317
Query: 3152 PSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIREN 3331
SGCGKST + LL+RLYDP EG V++D D+R +N ++LR+ I +VSQEP+LF T+I EN
Sbjct: 318 NSGCGKSTTVQLLQRLYDPTEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAEN 377
Query: 3332 IVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARAL 3511
I YG + T ++IE A +AN + FI +LP ++T VGE+G QLSGGQKQRIAIARAL
Sbjct: 378 IRYGRE--NVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARAL 435
Query: 3512 IRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQ 3691
+RNPKILLLDEATSALDTESE VQ ALD A + RT IV+AHRLST+ NA I G
Sbjct: 436 VRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADIIAGFDGGV 495
Query: 3692 VVEQGTHNELIAKRGAYFALTQKQSS 3769
+VEQG H EL+ ++G YF L Q++
Sbjct: 496 IVEQGNHEELMREKGIYFKLVMTQTA 521
>gi|1362689|pir||S55692 multidrug resistance protein homolog (mdr) -
African clawed frog
Length = 1287
Score = 1045 bits (2702), Expect = 0.0
Identities = 571/1260 (45%), Positives = 773/1260 (61%), Gaps = 19/1260 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+ +F ++RY+ST D++++ G I S A G LPLM ++ G ++ +FV +G + N T
Sbjct: 49 VGVFTMFRYSSTSDKMLMLFGTIASLAHGAALPLMMLVFGEMTDSFVNVGQVDTG-NFTW 107
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
A E ++ Y LG G+ ++Q S + + + + R FFH+V+R
Sbjct: 108 ESMINASRELQGQMTTYAYYYSGLGFGVMLCAYIQISFWTLSAGRQIKKIRSNFFHAVLR 167
Query: 401 QEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLI 580
QEI W+D N +G L+ +L D++ ++ EG GDK+ + Q + + GF + F W LT +
Sbjct: 168 QEIGWFDINDAGELNTRLTDDVSKINEGIGDKIAMLLQSLTTLVTGFIIGFIKGWKLTWV 227
Query: 581 MMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRY 760
M ++SP M + YA AG +AEEVL+SIRTV AF GQ E RY
Sbjct: 228 MGAISPIMGLSAAIWAKVLSAFTNKELKAYAKAGAVAEEVLSSIRTVFAFGGQNKEIHRY 287
Query: 761 EDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFS 940
E LE KK GIKK+ + F++IYA+Y LAFW GT + G G+VLTVFF+
Sbjct: 288 EKNLEDAKKIGIKKAITANVSIGFAFLMIYAAYSLAFWYGTTLIIDGGYTIGSVLTVFFA 347
Query: 941 VMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKV 1120
V++G+ A+GQ A GAA +++ +ID P+ID++S EG P KI G I V
Sbjct: 348 VIIGAFAVGQTSPNIEAFANARGAAYTIFNIIDNQPKIDSFSKEGLKPDKIKGDIEFKNV 407
Query: 1121 EFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIP 1300
FTYP+R D+++LKG++L+ G+TVALVGSSGCGKST +QL+QRFY+P+ G I +D
Sbjct: 408 IFTYPSRKDIQVLKGLNLNIPSGKTVALVGSSGCGKSTTVQLIQRFYDPEDGVITLDGQD 467
Query: 1301 IEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFP 1480
I NI+YLR+++GVVSQEP LF+T+I NIRYGR DV+ E+I RA KEANA DFI P
Sbjct: 468 IRSLNIRYLREIIGVVSQEPILFDTTIADNIRYGREDVTKEEIERATKEANAYDFIMKLP 527
Query: 1481 EGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENAS 1660
+ L TLVG+RG Q+SGGQKQRIAIARALVRNPKILLLDEATSALD ESE++VQSAL+ A
Sbjct: 528 DKLETLVGERGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQSALDKAR 587
Query: 1661 RGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVDDK 1840
GRTTIV+AHRLST+RNA+ I G ++E G+H+ L+E+ G+Y LV Q D
Sbjct: 588 EGRTTIVVAHRLSTIRNANAIAGFDNGVIVEQGSHKELMERGGVYFNLVTLQTVETSKDT 647
Query: 1841 PKKKE-----------------AERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXX 1969
+ E R+ SR T + K +T++ +VD
Sbjct: 648 EEDLETHIYEKKIPVTHTHSNLVRRKSSRNTIKSKVP---ETEDKEVD------------ 692
Query: 1970 XXXXXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQII 2149
G + FK+++ +PEW Y +I GA PAF++ FS+II
Sbjct: 693 ------EEEKKKEEGPPPVSFFKVMKLNKPEWPYFVVGVICAMINGATQPAFAIIFSRII 746
Query: 2150 NVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVL 2329
VF+ P QM+ + ++L+FL L V + Q FG A E LTMR+R ++++L
Sbjct: 747 GVFAGP-VSQMRSESSMYSLLFLALGGVSFITFFLQRFTFGKAGEILTMRLRLGSFKSML 805
Query: 2330 RQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQM 2509
RQ+ +FD K+S G +TTRLATDA ++ A RL + +A++G + I+F YGWQ+
Sbjct: 806 RQEIGWFDDSKNSTGALTTRLATDASQVQGATGTRLALLAQNVANLGTAIIISFIYGWQL 865
Query: 2510 AFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLY 2689
L++AI P +A + MK G A D KE+E AGK + +A+ NIRTV +LT + K
Sbjct: 866 TLLILAIVPVIAAAGLVEMKMFAGHAKKDKKELEKAGKISTDAVLNIRTVVSLTRERKFE 925
Query: 2690 NIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFR-FGLFLIFDKNVLMEPENV 2866
++ L+ P+ +I KA + GLTYG + + F G +L+ + LM+ + V
Sbjct: 926 AMYEKSLEGPYRNSIKKAHLHGLTYGLSQAHHVLCLCWVFSVLGAYLVVEG--LMKLDEV 983
Query: 2867 LRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGE 3043
V AI +G +S+ P+Y KA +A IF++LE P+ID + G P+ SG
Sbjct: 984 FLVSSAIVLGAMALGQTSSFAPDYTKAMISAAHIFSLLERVPQIDSYSDQGEKPKNCSGN 1043
Query: 3044 VKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAV 3223
V V F YP RP + +LQGL++ VK G+TLALVG SGCGKST +SLLER YDP EG V
Sbjct: 1044 VVFKGVNFNYPTRPDITVLQGLDISVKQGETLALVGSSGCGKSTTVSLLERFYDPFEGEV 1103
Query: 3224 TVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANI 3403
VD +R +N + +R + +VSQEPILFD SI +NI YG + T E+IETA +ANI
Sbjct: 1104 LVDGLSVRNLNIQWVRAQMGIVSQEPILFDCSIGDNIAYGDNNRKVTQEEIETAAKEANI 1163
Query: 3404 HKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQV 3583
H FI+ L D Y TRVG+KGTQLSGGQKQRIAIARALIR PKILLLDEATSALDTESEK V
Sbjct: 1164 HSFIESLTDKYNTRVGDKGTQLSGGQKQRIAIARALIRKPKILLLDEATSALDTESEKVV 1223
Query: 3584 QVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQ 3763
Q ALD A RTCIV+AHRLSTI NA I V++NG+VVEQGTH +L+ +G YF+L Q
Sbjct: 1224 QEALDKARMGRTCIVIAHRLSTIQNADKIAVIQNGKVVEQGTHQQLLQLKGVYFSLVTIQ 1283
Score = 395 bits (1014), Expect = e-108
Identities = 230/581 (39%), Positives = 344/581 (58%), Gaps = 7/581 (1%)
Frame = +2
Query: 98 VGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHEVIQNCL 277
VG+I + G P +II + +G +F P S +++ + L
Sbjct: 723 VGVICAMINGATQPAFAIIFSRI------IG-VFAGPVSQMRSESSMYS----------L 765
Query: 278 KYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYD--KNTSGTLSNK 451
++ LG F FLQ F E L+ R R F S++RQEI W+D KN++G L+ +
Sbjct: 766 LFLALGGVSFITFFLQRFTFGKAGEILTMRLRLGSFKSMLRQEIGWFDDSKNSTGALTTR 825
Query: 452 LFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXXX 631
L + +V+ TG ++ L Q +A ++F Y W LTL+++++ P + GL
Sbjct: 826 LATDASQVQGATGTRLALLAQNVANLGTAIIISFIYGWQLTLLILAIVPVIAAAGLVEMK 885
Query: 632 XXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFL 811
+ AG I+ + + +IRTV++ + YE +LE + IKK+ L
Sbjct: 886 MFAGHAKKDKKELEKAGKISTDAVLNIRTVVSLTRERKFEAMYEKSLEGPYRNSIKKAHL 945
Query: 812 IGA--GLASFFVIIYASYCLAFWV-GTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQ 982
G GL+ ++ C F V G V G ++ V V ++++G+MALGQ
Sbjct: 946 HGLTYGLSQAHHVL--CLCWVFSVLGAYLVVEGLMKLDEVFLVSSAIVLGAMALGQTSSF 1003
Query: 983 FATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILK 1162
A+ +AA ++ +++R+P+ID+YS +G+ P SG + V F YPTR D+ +L+
Sbjct: 1004 APDYTKAMISAAHIFSLLERVPQIDSYSDQGEKPKNCSGNVVFKGVNFNYPTRPDITVLQ 1063
Query: 1163 GVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVG 1342
G+ + + G+T+ALVGSSGCGKST + LL+RFY+P G++L+D + + + NI+++R +G
Sbjct: 1064 GLDISVKQGETLALVGSSGCGKSTTVSLLERFYDPFEGEVLVDGLSVRNLNIQWVRAQMG 1123
Query: 1343 VVSQEPNLFNTSIEQNIRYGRSD--VSDEDIARALKEANAADFIKTFPEGLNTLVGDRGV 1516
+VSQEP LF+ SI NI YG ++ V+ E+I A KEAN FI++ + NT VGD+G
Sbjct: 1124 IVSQEPILFDCSIGDNIAYGDNNRKVTQEEIETAAKEANIHSFIESLTDKYNTRVGDKGT 1183
Query: 1517 QMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRL 1696
Q+SGGQKQRIAIARAL+R PKILLLDEATSALD ESE +VQ AL+ A GRT IVIAHRL
Sbjct: 1184 QLSGGQKQRIAIARALIRKPKILLLDEATSALDTESEKVVQEALDKARMGRTCIVIAHRL 1243
Query: 1697 STVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQV 1819
ST++NADKI V++ G+V+E GTH+ L++ KG+Y LV Q+
Sbjct: 1244 STIQNADKIAVIQNGKVVEQGTHQQLLQLKGVYFSLVTIQL 1284
Score = 392 bits (1007), Expect = e-107
Identities = 239/615 (38%), Positives = 341/615 (54%), Gaps = 19/615 (3%)
Frame = +2
Query: 2021 KANLFKILRYARP-EWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGH 2197
K +F + RY+ + + L GA +P L F ++ + F N Q+
Sbjct: 48 KVGVFTMFRYSSTSDKMLMLFGTIASLAHGAALPLMMLVFGEMTDSFVNVG--QVDTGNF 105
Query: 2198 FWALMFLVLAAVQGTSMLF-----------------QCSLFGVAAERLTMRIRSKVYRNV 2326
W M +QG + Q S + ++A R +IRS + V
Sbjct: 106 TWESMINASRELQGQMTTYAYYYSGLGFGVMLCAYIQISFWTLSAGRQIKKIRSNFFHAV 165
Query: 2327 LRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQ 2506
LRQ+ +FD+ + G + TRL D I I ++ + ++ ++ G I F GW+
Sbjct: 166 LRQEIGWFDI--NDAGELNTRLTDDVSKINEGIGDKIAMLLQSLTTLVTGFIIGFIKGWK 223
Query: 2507 MAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKL 2686
+ +++ AI P M + A+ K + K AG A E + +IRTV A Q K
Sbjct: 224 LTWVMGAISPIMGLSAAIWAKVLSAFTNKELKAYAKAGAVAEEVLSSIRTVFAFGGQNKE 283
Query: 2687 YNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENV 2866
+ + +L+ I KAI ++ GFA + + Y+ AF +G LI D + +V
Sbjct: 284 IHRYEKNLEDAKKIGIKKAITANVSIGFAFLMIYAAYSLAFWYGTTLIIDGGYTIG--SV 341
Query: 2867 LRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYP-QLSGE 3043
L V FA+ +G + + A AA IFN+++ +P+ID + G P ++ G+
Sbjct: 342 LTVFFAVIIGAFAVGQTSPNIEAFANARGAAYTIFNIIDNQPKIDSFSKEGLKPDKIKGD 401
Query: 3044 VKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAV 3223
++ V F YP R + +L+GLN+++ G+T+ALVG SGCGKST + L++R YDP +G +
Sbjct: 402 IEFKNVIFTYPSRKDIQVLKGLNLNIPSGKTVALVGSSGCGKSTTVQLIQRFYDPEDGVI 461
Query: 3224 TVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANI 3403
T+D D+R +N ++LR+ I +VSQEPILFDT+I +NI YG + + T E+IE A +AN
Sbjct: 462 TLDGQDIRSLNIRYLREIIGVVSQEPILFDTTIADNIRYGRE--DVTKEEIERATKEANA 519
Query: 3404 HKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQV 3583
+ FI +LPD ET VGE+GTQLSGGQKQRIAIARAL+RNPKILLLDEATSALDTESE V
Sbjct: 520 YDFIMKLPDKLETLVGERGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVV 579
Query: 3584 QVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQ 3763
Q ALD A + RT IVVAHRLSTI NA I NG +VEQG+H EL+ + G YF L Q
Sbjct: 580 QSALDKAREGRTTIVVAHRLSTIRNANAIAGFDNGVIVEQGSHKELMERGGVYFNLVTLQ 639
Query: 3764 SSNQSGGAFDTSEAL 3808
+ S DT E L
Sbjct: 640 TVETSK---DTEEDL 651
>gi|833699|gb|AAA75000.1| multidrug resistance protein
gi|1098061|prf||2115220A P-glycoprotein
Length = 1287
Score = 1045 bits (2702), Expect = 0.0
Identities = 571/1260 (45%), Positives = 773/1260 (61%), Gaps = 19/1260 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+ +F ++RY+ST D++++ G I S A G LPLM ++ G ++ +FV +G + N T
Sbjct: 49 VGVFTMFRYSSTSDKMLMLFGTIASLAHGAALPLMMLVFGEMTDSFVNVGQVDTG-NFTW 107
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
A E ++ Y LG G+ ++Q S + + + + R FFH+V+R
Sbjct: 108 ESMINASRELQGQMTTYAYYYSGLGFGVMLCAYIQISFWTLSAGRQIKKIRSNFFHAVLR 167
Query: 401 QEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLI 580
QEI W+D N +G L+ +L D++ ++ EG GDK+ + Q + + GF + F W LT +
Sbjct: 168 QEIGWFDINDAGELNTRLTDDVSKINEGIGDKIAMLLQSLTTLVTGFIIGFIKGWKLTWV 227
Query: 581 MMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRY 760
M ++SP M + YA AG +AEEVL+SIRTV AF GQ E RY
Sbjct: 228 MGAISPIMGLSAAIWAKVLSAFTNKELKAYAKAGAVAEEVLSSIRTVFAFGGQNKEIHRY 287
Query: 761 EDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFS 940
E LE KK GIKK+ + F++IYA+Y LAFW GT + G G+VLTVFF+
Sbjct: 288 EKNLEDAKKIGIKKAITANVSIGFAFLMIYAAYSLAFWYGTTLIIDGGYTIGSVLTVFFA 347
Query: 941 VMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKV 1120
V++G+ A+GQ A GAA +++ +ID P+ID++S EG P KI G I V
Sbjct: 348 VIIGAFAVGQTSPNIEAFANARGAAYTIFNIIDNQPKIDSFSKEGLKPDKIKGDIEFKNV 407
Query: 1121 EFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIP 1300
FTYP+R D+++LKG++L+ G+TVALVGSSGCGKST +QL+QRFY+P+ G I +D
Sbjct: 408 IFTYPSRKDIQVLKGLNLNIPSGKTVALVGSSGCGKSTTVQLIQRFYDPEDGVITLDGQD 467
Query: 1301 IEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFP 1480
I NI+YLR+++GVVSQEP LF+T+I NIRYGR DV+ E+I RA KEANA DFI P
Sbjct: 468 IRSLNIRYLREIIGVVSQEPILFDTTIADNIRYGREDVTKEEIERATKEANAYDFIMKLP 527
Query: 1481 EGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENAS 1660
+ L TLVG+RG Q+SGGQKQRIAIARALVRNPKILLLDEATSALD ESE++VQSAL+ A
Sbjct: 528 DKLETLVGERGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQSALDKAR 587
Query: 1661 RGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVDDK 1840
GRTTIV+AHRLST+RNA+ I G ++E G+H+ L+E+ G+Y LV Q D
Sbjct: 588 EGRTTIVVAHRLSTIRNANAIAGFDNGVIVEQGSHKELMERGGVYFNLVTLQTVETSKDT 647
Query: 1841 PKKKE-----------------AERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXX 1969
+ E R+ SR T + K +T++ +VD
Sbjct: 648 EEDLETHIYEKKIPVTHTHSNLVRRKSSRNTIKSKVP---ETEDKEVD------------ 692
Query: 1970 XXXXXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQII 2149
G + FK+++ +PEW Y +I GA PAF++ FS+II
Sbjct: 693 ------EEEKKKEEGPPPVSFFKVMKLNKPEWPYFVVGVICAMINGATQPAFAIIFSRII 746
Query: 2150 NVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVL 2329
VF+ P QM+ + ++L+FL L V + Q FG A E LTMR+R ++++L
Sbjct: 747 GVFAGP-VSQMRSESSMYSLLFLALGGVSFITFFLQGFTFGKAGEILTMRLRLGSFKSML 805
Query: 2330 RQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQM 2509
RQ+ +FD K+S G +TTRLATDA ++ A RL + +A++G + I+F YGWQ+
Sbjct: 806 RQEIGWFDDSKNSTGALTTRLATDASQVQGATGTRLALLAQNVANLGTAIIISFIYGWQL 865
Query: 2510 AFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLY 2689
L++AI P +A + MK G A D KE+E AGK + +A+ NIRTV +LT + K
Sbjct: 866 TLLILAIVPVIAAAGLVEMKMFAGHAKKDKKELEKAGKISTDAVLNIRTVVSLTRERKFE 925
Query: 2690 NIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFR-FGLFLIFDKNVLMEPENV 2866
++ L+ P+ +I KA + GLTYG + + F G +L+ + LM+ + V
Sbjct: 926 AMYEKSLEGPYRNSIKKAHLHGLTYGLSQAHHVLCLCWVFSVLGAYLVVEG--LMKLDEV 983
Query: 2867 LRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGE 3043
V AI +G +S+ P+Y KA +A IF++LE P+ID + G P+ SG
Sbjct: 984 FLVSSAIVLGAMALGQTSSFAPDYTKAMISAAHIFSLLERVPQIDSYSDQGEKPKNCSGN 1043
Query: 3044 VKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAV 3223
V V F YP RP + +LQGL++ VK G+TLALVG SGCGKST +SLLER YDP EG V
Sbjct: 1044 VVFKGVNFNYPTRPDITVLQGLDISVKQGETLALVGSSGCGKSTTVSLLERFYDPFEGEV 1103
Query: 3224 TVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANI 3403
VD +R +N + +R + +VSQEPILFD SI +NI YG + T E+IETA +ANI
Sbjct: 1104 LVDGLSVRNLNIQWVRAQMGIVSQEPILFDCSIGDNIAYGDNNRKVTQEEIETAAKEANI 1163
Query: 3404 HKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQV 3583
H FI+ L D Y TRVG+KGTQLSGGQKQRIAIARALIR PKILLLDEATSALDTESEK V
Sbjct: 1164 HSFIESLTDKYNTRVGDKGTQLSGGQKQRIAIARALIRKPKILLLDEATSALDTESEKVV 1223
Query: 3584 QVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQ 3763
Q ALD A RTCIV+AHRLSTI NA I V++NG+VVEQGTH +L+ +G YF+L Q
Sbjct: 1224 QEALDKARMGRTCIVIAHRLSTIQNADKIAVIQNGKVVEQGTHQQLLQLKGVYFSLVTIQ 1283
Score = 395 bits (1015), Expect = e-108
Identities = 230/581 (39%), Positives = 344/581 (58%), Gaps = 7/581 (1%)
Frame = +2
Query: 98 VGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHEVIQNCL 277
VG+I + G P +II + +G +F P S +++ + L
Sbjct: 723 VGVICAMINGATQPAFAIIFSRI------IG-VFAGPVSQMRSESSMYS----------L 765
Query: 278 KYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYD--KNTSGTLSNK 451
++ LG F FLQ F E L+ R R F S++RQEI W+D KN++G L+ +
Sbjct: 766 LFLALGGVSFITFFLQGFTFGKAGEILTMRLRLGSFKSMLRQEIGWFDDSKNSTGALTTR 825
Query: 452 LFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXXX 631
L + +V+ TG ++ L Q +A ++F Y W LTL+++++ P + GL
Sbjct: 826 LATDASQVQGATGTRLALLAQNVANLGTAIIISFIYGWQLTLLILAIVPVIAAAGLVEMK 885
Query: 632 XXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFL 811
+ AG I+ + + +IRTV++ + YE +LE + IKK+ L
Sbjct: 886 MFAGHAKKDKKELEKAGKISTDAVLNIRTVVSLTRERKFEAMYEKSLEGPYRNSIKKAHL 945
Query: 812 IGA--GLASFFVIIYASYCLAFWV-GTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQ 982
G GL+ ++ C F V G V G ++ V V ++++G+MALGQ
Sbjct: 946 HGLTYGLSQAHHVL--CLCWVFSVLGAYLVVEGLMKLDEVFLVSSAIVLGAMALGQTSSF 1003
Query: 983 FATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILK 1162
A+ +AA ++ +++R+P+ID+YS +G+ P SG + V F YPTR D+ +L+
Sbjct: 1004 APDYTKAMISAAHIFSLLERVPQIDSYSDQGEKPKNCSGNVVFKGVNFNYPTRPDITVLQ 1063
Query: 1163 GVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVG 1342
G+ + + G+T+ALVGSSGCGKST + LL+RFY+P G++L+D + + + NI+++R +G
Sbjct: 1064 GLDISVKQGETLALVGSSGCGKSTTVSLLERFYDPFEGEVLVDGLSVRNLNIQWVRAQMG 1123
Query: 1343 VVSQEPNLFNTSIEQNIRYGRSD--VSDEDIARALKEANAADFIKTFPEGLNTLVGDRGV 1516
+VSQEP LF+ SI NI YG ++ V+ E+I A KEAN FI++ + NT VGD+G
Sbjct: 1124 IVSQEPILFDCSIGDNIAYGDNNRKVTQEEIETAAKEANIHSFIESLTDKYNTRVGDKGT 1183
Query: 1517 QMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRL 1696
Q+SGGQKQRIAIARAL+R PKILLLDEATSALD ESE +VQ AL+ A GRT IVIAHRL
Sbjct: 1184 QLSGGQKQRIAIARALIRKPKILLLDEATSALDTESEKVVQEALDKARMGRTCIVIAHRL 1243
Query: 1697 STVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQV 1819
ST++NADKI V++ G+V+E GTH+ L++ KG+Y LV Q+
Sbjct: 1244 STIQNADKIAVIQNGKVVEQGTHQQLLQLKGVYFSLVTIQL 1284
Score = 392 bits (1007), Expect = e-107
Identities = 239/615 (38%), Positives = 341/615 (54%), Gaps = 19/615 (3%)
Frame = +2
Query: 2021 KANLFKILRYARP-EWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGH 2197
K +F + RY+ + + L GA +P L F ++ + F N Q+
Sbjct: 48 KVGVFTMFRYSSTSDKMLMLFGTIASLAHGAALPLMMLVFGEMTDSFVNVG--QVDTGNF 105
Query: 2198 FWALMFLVLAAVQGTSMLF-----------------QCSLFGVAAERLTMRIRSKVYRNV 2326
W M +QG + Q S + ++A R +IRS + V
Sbjct: 106 TWESMINASRELQGQMTTYAYYYSGLGFGVMLCAYIQISFWTLSAGRQIKKIRSNFFHAV 165
Query: 2327 LRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQ 2506
LRQ+ +FD+ + G + TRL D I I ++ + ++ ++ G I F GW+
Sbjct: 166 LRQEIGWFDI--NDAGELNTRLTDDVSKINEGIGDKIAMLLQSLTTLVTGFIIGFIKGWK 223
Query: 2507 MAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKL 2686
+ +++ AI P M + A+ K + K AG A E + +IRTV A Q K
Sbjct: 224 LTWVMGAISPIMGLSAAIWAKVLSAFTNKELKAYAKAGAVAEEVLSSIRTVFAFGGQNKE 283
Query: 2687 YNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENV 2866
+ + +L+ I KAI ++ GFA + + Y+ AF +G LI D + +V
Sbjct: 284 IHRYEKNLEDAKKIGIKKAITANVSIGFAFLMIYAAYSLAFWYGTTLIIDGGYTIG--SV 341
Query: 2867 LRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYP-QLSGE 3043
L V FA+ +G + + A AA IFN+++ +P+ID + G P ++ G+
Sbjct: 342 LTVFFAVIIGAFAVGQTSPNIEAFANARGAAYTIFNIIDNQPKIDSFSKEGLKPDKIKGD 401
Query: 3044 VKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAV 3223
++ V F YP R + +L+GLN+++ G+T+ALVG SGCGKST + L++R YDP +G +
Sbjct: 402 IEFKNVIFTYPSRKDIQVLKGLNLNIPSGKTVALVGSSGCGKSTTVQLIQRFYDPEDGVI 461
Query: 3224 TVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANI 3403
T+D D+R +N ++LR+ I +VSQEPILFDT+I +NI YG + + T E+IE A +AN
Sbjct: 462 TLDGQDIRSLNIRYLREIIGVVSQEPILFDTTIADNIRYGRE--DVTKEEIERATKEANA 519
Query: 3404 HKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQV 3583
+ FI +LPD ET VGE+GTQLSGGQKQRIAIARAL+RNPKILLLDEATSALDTESE V
Sbjct: 520 YDFIMKLPDKLETLVGERGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVV 579
Query: 3584 QVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQ 3763
Q ALD A + RT IVVAHRLSTI NA I NG +VEQG+H EL+ + G YF L Q
Sbjct: 580 QSALDKAREGRTTIVVAHRLSTIRNANAIAGFDNGVIVEQGSHKELMERGGVYFNLVTLQ 639
Query: 3764 SSNQSGGAFDTSEAL 3808
+ S DT E L
Sbjct: 640 TVETSK---DTEEDL 651
>gi|9961250|ref|NP_061337.1| ATP-binding cassette, subfamily B, member
4 isoform B; P glycoprotein 3/multiple drug resistance 3;
P-glycoprotein-3/multiple drug resistance-3; multiple
drug resistance 3 [Homo sapiens]
Length = 1286
Score = 1042 bits (2695), Expect = 0.0
Identities = 569/1267 (44%), Positives = 789/1267 (61%), Gaps = 21/1267 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
I + L+RY+ D+L +++G I++ A G GLPLM I+ G ++ FV F P + +
Sbjct: 40 IGVLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFS 99
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
E+ + Y LG G+ A ++Q S + + + + R++FFH+++R
Sbjct: 100 LSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILR 159
Query: 401 QEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLI 580
QEI W+D N + L+ +L D++ ++ EG GDKVG+ FQ +A F GF V F W LTL+
Sbjct: 160 QEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLV 219
Query: 581 MMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRY 760
+M++SP + + YA AG +AEE L +IRTVIAF GQ E +RY
Sbjct: 220 IMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERY 279
Query: 761 EDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFS 940
+ LE+ K+ GIKK+ + F++IYASY LAFW G+ V S G +TVFFS
Sbjct: 280 QKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFS 339
Query: 941 VMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKV 1120
+++G+ ++GQA A GAA ++++ID P+ID++S G P I G + N V
Sbjct: 340 ILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDV 399
Query: 1121 EFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIP 1300
F+YP+RA+VKILKG++L Q GQTVALVGSSGCGKST +QL+QR Y+PD G I ID
Sbjct: 400 HFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQD 459
Query: 1301 IEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFP 1480
I +FN+ YLR+++GVVSQEP LF+T+I +NI YGR +V+ ++I +A+KEANA +FI P
Sbjct: 460 IRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLP 519
Query: 1481 EGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENAS 1660
+ +TLVG+RG Q+SGGQKQRIAIARALVRNPKILLLDEATSALD ESE+ VQ+AL+ A
Sbjct: 520 QKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAR 579
Query: 1661 RGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQV------- 1819
GRTTIVIAHRLSTVRNAD I + G ++E G+H L++++G+Y +LV+ Q
Sbjct: 580 EGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQS 639
Query: 1820 --FADVDDKPKKKEA----ERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXX 1981
F D+K + A + R+ R ++Q K N + + +D
Sbjct: 640 EEFELNDEKAATRMAPNGWKSRLFRHSTQ-KNLKNSQMCQKSLD---------------- 682
Query: 1982 XXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFS 2161
+ K+L+ + EW Y + G + PAFS+ FS+II +F
Sbjct: 683 --VETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFG 740
Query: 2162 NPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDA 2341
D ++ + ++L+FL L + + Q FG A E LT R+RS ++ +LRQD
Sbjct: 741 PGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDM 800
Query: 2342 TYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLV 2521
++FD K+S G ++TRLATDA ++ A RL I IA++G G+ I+F YGWQ+ L+
Sbjct: 801 SWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLL 860
Query: 2522 MAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFC 2701
+A+ P +AV + MK G+A D KE+E AGK A EAIENIRTV +LT + K +++
Sbjct: 861 LAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYV 920
Query: 2702 SHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLF 2881
L P+ ++ KA I G+T+ + + +F+YA FRFG +LI N M +V+ V
Sbjct: 921 EKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIV--NGHMRFRDVILVFS 978
Query: 2882 AISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYP-QLSGEVKLNK 3058
AI F +G A+S+ P+Y KA +A +F + E +P ID + G P + G + N+
Sbjct: 979 AIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNE 1038
Query: 3059 VFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTV--- 3229
V F YP R VP+LQGL++ VK GQTLALVG SGCGKSTV+ LLER YDPL G V V
Sbjct: 1039 VVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFG 1098
Query: 3230 ----DNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKA 3397
D + +++N + LR + +VSQEPILFD SI ENI YG + ++I +A A
Sbjct: 1099 FQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAA 1158
Query: 3398 NIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEK 3577
NIH FI+ LP YETRVG+KGTQLSGGQKQRIAIARALIR P+ILLLDEATSALDTESEK
Sbjct: 1159 NIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEK 1218
Query: 3578 QVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQ 3757
VQ ALD A + RTCIV+AHRLSTI NA I+V +NG+V E GTH +L+A++G YF++
Sbjct: 1219 VVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVS 1278
Query: 3758 KQSSNQS 3778
Q+ Q+
Sbjct: 1279 VQAGTQN 1285
>gi|1170902|sp|P43245|MDR1_RAT Multidrug resistance protein 1
(P-glycoprotein 1)
gi|92489|pir||JH0502 p-glycoprotein - rat
Length = 1277
Score = 1038 bits (2683), Expect = 0.0
Identities = 551/1252 (44%), Positives = 783/1252 (62%), Gaps = 13/1252 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+ IF ++RY +D+L +A+G + + G LPL+ ++ G ++ +F T DP+S
Sbjct: 32 VGIFGMFRYADWLDKLCMALGTLAAIIHGTLLPLLMLVFGYMTDSF----TPSRDPHSDR 87
Query: 221 SEKAAARAEFSHEVIQNCLK---------YVYLGCGIFAAGFLQASCFMVICEKLSNRFR 373
+ + +H V L+ Y +G G+ ++Q S + + + ++ R
Sbjct: 88 AITNQSEINSTHTVSDTSLEEDMAMYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIR 147
Query: 374 RQFFHSVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAF 553
++FFH++M QEI W+D N +G L+ +L D++ ++ +G GDK+G+ FQ + F GF + F
Sbjct: 148 QKFFHAIMNQEIGWFDVNDAGELNTRLTDDVSKINDGIGDKLGMFFQSITTFSAGFIIGF 207
Query: 554 TYDWLLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFN 733
W LTL+++++SP + + YA AG +AEEVL +IRTVIAF
Sbjct: 208 ISGWKLTLVILAVSPLIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRTVIAFG 267
Query: 734 GQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLES 913
GQ+ E +RY LE K+ GIKK+ + ++++YASY LAFW GT+ V S
Sbjct: 268 GQKKELERYNKNLEEAKRVGIKKAITANISIGIAYLLVYASYALAFWYGTSLVLSNEYSI 327
Query: 914 GTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKI 1093
G VLTVFFS+++G+ ++G A GAA ++++ID P ID++ST+G P I
Sbjct: 328 GQVLTVFFSILLGTFSIGHLAPNIEAFANARGAAYEIFKIIDNEPSIDSFSTKGHKPDSI 387
Query: 1094 SGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDA 1273
G + V F YP+R++VKILKG++L + GQTVALVG+SGCGKST +QLLQR Y+P
Sbjct: 388 MGNLEFKNVYFNYPSRSEVKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIE 447
Query: 1274 GQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEAN 1453
G++ ID I N++YLR+++GVVSQEP LF T+I +NIRYGR +V+ ++I +A+KEAN
Sbjct: 448 GEVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEAN 507
Query: 1454 AADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESI 1633
A DFI P +TLVG+RG Q+SGGQKQRIAIARALVRNPKILLLDEATSALD ESE++
Sbjct: 508 AYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAV 567
Query: 1634 VQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHA 1813
VQ+AL+ A GRTTIVIAHRLSTVRNAD I G ++E G HE L+++KG+Y +LV
Sbjct: 568 VQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEELMKEKGIYFKLVMT 627
Query: 1814 QVFADVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXX 1993
Q + + +P E + S+ + + +S +
Sbjct: 628 QTRGN-EIEPGNNAYESQSDTGASE----LTSEESKSPLIRRSIRRSIHRRQDQERRLSS 682
Query: 1994 XXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDR 2173
+ ++IL+ EW Y +I G + P F++ FS+I+ VFS D
Sbjct: 683 KEDVDEDVPMVSFWQILKLNISEWPYLVVGVLCAVINGCIQPVFAIVFSKIVGVFSRDDD 742
Query: 2174 DQMK-KDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYF 2350
+ K ++ + ++L+FLV+ + + FQ FG A E LT R+R V++++LRQD ++F
Sbjct: 743 HETKQRNCNLFSLLFLVMGMISFVTYFFQGFTFGKAGEILTKRLRYMVFKSMLRQDISWF 802
Query: 2351 DMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGG--LGIAFYYGWQMAFLVM 2524
D K++ G +TTRLA+DA N+K A+ RL + +A++G G L + YGWQ+ L++
Sbjct: 803 DDHKNTTGSLTTRLASDASNVKGAMGSRLAVVTQNVANLGTGIILSLVLVYGWQLTLLLV 862
Query: 2525 AIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCS 2704
I P + +G + MK G A D KE+E +GK A EAIEN RTV +LT + K ++
Sbjct: 863 VIIPLIVLGGIIEMKLLSGQALKDKKELEISGKIATEAIENFRTVVSLTREQKFETMYAQ 922
Query: 2705 HLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFA 2884
L P+ + KA + G+T+ F ++ +F+YAA FRFG +L+ LM ENV+ V A
Sbjct: 923 SLQIPYRNALKKAHVFGITFAFTQAMIYFSYAACFRFGAYLV--ARELMTFENVMLVFSA 980
Query: 2885 ISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKLNKV 3061
+ F G +S+ P+Y KA +A I ++E+ P ID ++ G P L G VK N V
Sbjct: 981 VVFGAMAAGNTSSFAPDYAKAKVSASHIIGIIEKIPEIDSYSTEGLKPNWLEGNVKFNGV 1040
Query: 3062 FFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNND 3241
F YP RP +P+LQGL+ VK GQTL LVG SGCGKSTV+ LLER Y+P+ G V +D +
Sbjct: 1041 KFNYPTRPNIPVLQGLSFEVKKGQTLRLVGSSGCGKSTVVQLLERFYNPMAGTVFLDGKE 1100
Query: 3242 LRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDE 3421
++Q+N + +R + +VSQEPILFD SI ENI YG +HE+I A +ANIH+FID
Sbjct: 1101 IKQLNVQCVRA-LGIVSQEPILFDCSIAENIAYGDNSRVVSHEEIVRAAREANIHQFIDS 1159
Query: 3422 LPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDA 3601
LP+ Y TRVG+KGTQLSGGQKQRIAIARAL+R P ILLLDEATSALDTESEK VQ ALD
Sbjct: 1160 LPEKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDK 1219
Query: 3602 AAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQ 3757
A + RTC+V+AHRLSTI NA I+V++NGQV E GTH +L+A++G YF++ Q
Sbjct: 1220 AREGRTCVVIAHRLSTIQNADLIVVIQNGQVKEHGTHQQLLAQKGIYFSMVQ 1271
Score = 400 bits (1027), Expect = e-109
Identities = 228/584 (39%), Positives = 338/584 (57%), Gaps = 10/584 (1%)
Frame = +2
Query: 92 LAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHEVIQN 271
L VG++ + G P+ +I+ + +G D + ++ N
Sbjct: 709 LVVGVLCAVINGCIQPVFAIVFSKI------VGVFSRDDDHETKQR-------------N 749
Query: 272 C----LKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYD--KNTS 433
C L ++ +G F F Q F E L+ R R F S++RQ+I+W+D KNT+
Sbjct: 750 CNLFSLLFLVMGMISFVTYFFQGFTFGKAGEILTKRLRYMVFKSMLRQDISWFDDHKNTT 809
Query: 434 GTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGF--AVAFTYDWLLTLIMMSLSPFMM 607
G+L+ +L + V+ G ++ + Q +A G ++ Y W LTL+++ + P ++
Sbjct: 810 GSLTTRLASDASNVKGAMGSRLAVVTQNVANLGTGIILSLVLVYGWQLTLLLVVIIPLIV 869
Query: 608 ICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKK 787
+ G+ + ++G IA E + + RTV++ ++ Y +L+ +
Sbjct: 870 LGGIIEMKLLSGQALKDKKELEISGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYR 929
Query: 788 TGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALG 967
+KK+ + G A +IY SY F G V + V+ VF +V+ G+MA G
Sbjct: 930 NALKKAHVFGITFAFTQAMIYFSYAACFRFGAYLVARELMTFENVMLVFSAVVFGAMAAG 989
Query: 968 QAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRAD 1147
A +A+ + +I++IPEID+YSTEG P+ + G + N V+F YPTR +
Sbjct: 990 NTSSFAPDYAKAKVSASHIIGIIEKIPEIDSYSTEGLKPNWLEGNVKFNGVKFNYPTRPN 1049
Query: 1148 VKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYL 1327
+ +L+G+S + + GQT+ LVGSSGCGKST++QLL+RFYNP AG + +D I+ N++ +
Sbjct: 1050 IPVLQGLSFEVKKGQTLRLVGSSGCGKSTVVQLLERFYNPMAGTVFLDGKEIKQLNVQCV 1109
Query: 1328 RQLVGVVSQEPNLFNTSIEQNIRYGRSD--VSDEDIARALKEANAADFIKTFPEGLNTLV 1501
R L G+VSQEP LF+ SI +NI YG + VS E+I RA +EAN FI + PE NT V
Sbjct: 1110 RAL-GIVSQEPILFDCSIAENIAYGDNSRVVSHEEIVRAAREANIHQFIDSLPEKYNTRV 1168
Query: 1502 GDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIV 1681
GD+G Q+SGGQKQRIAIARALVR P ILLLDEATSALD ESE +VQ AL+ A GRT +V
Sbjct: 1169 GDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCVV 1228
Query: 1682 IAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHA 1813
IAHRLST++NAD I+V++ GQV E GTH+ L+ QKG+Y +V A
Sbjct: 1229 IAHRLSTIQNADLIVVIQNGQVKEHGTHQQLLAQKGIYFSMVQA 1272
Score = 385 bits (990), Expect = e-105
Identities = 234/605 (38%), Positives = 333/605 (54%), Gaps = 26/605 (4%)
Frame = +2
Query: 2030 LFKILRYARPEWI---YXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRD-------- 2176
+F + RYA +W+ +I G ++P L F + + F+ P RD
Sbjct: 34 IFGMFRYA--DWLDKLCMALGTLAAIIHGTLLPLLMLVFGYMTDSFT-PSRDPHSDRAIT 90
Query: 2177 --------------QMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKV 2314
+++D +A + + A Q SL+ +AA R +IR K
Sbjct: 91 NQSEINSTHTVSDTSLEEDMAMYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKF 150
Query: 2315 YRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFY 2494
+ ++ Q+ +FD+ + G + TRL D I I +LG F +I + G I F
Sbjct: 151 FHAIMNQEIGWFDV--NDAGELNTRLTDDVSKINDGIGDKLGMFFQSITTFSAGFIIGFI 208
Query: 2495 YGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTL 2674
GW++ +++A+ P + + A+ K + + AG A E + IRTV A
Sbjct: 209 SGWKLTLVILAVSPLIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRTVIAFGG 268
Query: 2675 QTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLME 2854
Q K + +L+ I KAI ++ G A + + +YA AF +G L+ +
Sbjct: 269 QKKELERYNKNLEEAKRVGIKKAITANISIGIAYLLVYASYALAFWYGTSLVLSNEYSIG 328
Query: 2855 PENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ- 3031
VL V F+I +IG A + A AA IF +++ EP ID ++ G P
Sbjct: 329 --QVLTVFFSILLGTFSIGHLAPNIEAFANARGAAYEIFKIIDNEPSIDSFSTKGHKPDS 386
Query: 3032 LSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPL 3211
+ G ++ V+F YP R V IL+GLN+ VK GQT+ALVG SGCGKST + LL+RLYDP+
Sbjct: 387 IMGNLEFKNVYFNYPSRSEVKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPI 446
Query: 3212 EGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACS 3391
EG V++D D+R +N ++LR+ I +VSQEP+LF T+I ENI YG + T ++IE A
Sbjct: 447 EGEVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRE--NVTMDEIEKAVK 504
Query: 3392 KANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTES 3571
+AN + FI +LP ++T VGE+G QLSGGQKQRIAIARAL+RNPKILLLDEATSALDTES
Sbjct: 505 EANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTES 564
Query: 3572 EKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFAL 3751
E VQ ALD A + RT IV+AHRLST+ NA I G +VEQG H EL+ ++G YF L
Sbjct: 565 EAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEELMKEKGIYFKL 624
Query: 3752 TQKQS 3766
Q+
Sbjct: 625 VMTQT 629
>gi|6679297|ref|NP_032856.1| ATP-binding cassette, sub-family B
(MDR/TAP), member 4; P glycoprotein 2 [Mus musculus]
gi|126929|sp|P21440|MDR2_MOUSE Multidrug resistance protein 2
(P-glycoprotein 2)
gi|72476|pir||DVMS2 multidrug resistance protein 2 - mouse
gi|387428|gb|AAA39516.1| multidrug resistance protein
Length = 1276
Score = 1034 bits (2674), Expect = 0.0
Identities = 556/1248 (44%), Positives = 786/1248 (62%), Gaps = 2/1248 (0%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFV-TLGTIFLDPNST 217
I + L+RY+ D+L + +G +++ A G GLPLM I+ G ++ FV G L N +
Sbjct: 37 IGLLTLFRYSDWQDKLFMFLGTLMAIAHGSGLPLMMIVFGEMTDKFVDNTGNFSLPVNFS 96
Query: 218 ASEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVM 397
S R E+ + Y LG G+ A ++Q S + + + + R++FFH+++
Sbjct: 97 LSMLNPGRI-LEEEMTRYAYYYSGLGGGVLVAAYIQVSFWTLAAGRQIKKIRQKFFHAIL 155
Query: 398 RQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
RQE+ W+D + L+ +L D++ ++ EG GDKVG+ FQ +A F GF V F W LTL
Sbjct: 156 RQEMGWFDIKGTTELNTRLTDDVSKISEGIGDKVGMFFQAIATFFAGFIVGFIRGWKLTL 215
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
++M++SP + + YA AG +AEE +IRTVIAF GQ E +R
Sbjct: 216 VIMAISPILGLSTAVWAKILSTFSDKELAAYAKAGAVAEEAPGAIRTVIAFGGQNKELER 275
Query: 758 YEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFF 937
Y+ LE+ KK GIKK+ + F++IYASY LAFW G+ V S G +TVFF
Sbjct: 276 YQKHLENAKKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFF 335
Query: 938 SVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNK 1117
S+++G+ ++GQA A GAA ++++ID P+ID++S G P I G + +
Sbjct: 336 SILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDNIKGNLEFSD 395
Query: 1118 VEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDI 1297
V F+YP+RA++KILKG++L + GQTVALVG+SGCGKST +QLLQR Y+P G+I ID
Sbjct: 396 VHFSYPSRANIKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGKISIDGQ 455
Query: 1298 PIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTF 1477
I +FN++ LR+++GVVSQEP LF+T+I +NIRYGR +V+ ++I +A+KEANA DFI
Sbjct: 456 DIRNFNVRCLREIIGVVSQEPVLFSTTIAENIRYGRGNVTMDEIEKAVKEANAYDFIMKL 515
Query: 1478 PEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENA 1657
P+ +TLVGDRG Q+SGGQKQRIAIARALVRNPKILLLDEATSALD ESE+ VQ+AL+ A
Sbjct: 516 PQKFDTLVGDRGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKA 575
Query: 1658 SRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVDD 1837
GRTTIVIAHRLST+RNAD I + G ++E G+H L++++G+Y LV+ Q
Sbjct: 576 REGRTTIVIAHRLSTIRNADVIAGFEDGVIVEQGSHSELMKKEGIYFRLVNMQT---AGS 632
Query: 1838 KPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXGA 2017
+ +E E +S + + G V ++++
Sbjct: 633 QILSEEFEVELSDE--KAAGDVAPNGWKARI-FRNSTKKSLKSPHQNRLDEETNELDANV 689
Query: 2018 VKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGH 2197
+ K+L+ + EW Y + GA+ PAFS+ S++I +F D ++ +
Sbjct: 690 PPVSFLKVLKLNKTEWPYFVVGTVCAIANGALQPAFSIILSEMIAIFGPGDDAVKQQKCN 749
Query: 2198 FWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGR 2377
++L+FL L + + Q FG A E LT R+RS ++ +LRQD ++FD K+S G
Sbjct: 750 MFSLVFLGLGVLSFFTFFLQGFTFGKAGEILTTRLRSMAFKAMLRQDMSWFDDHKNSTGA 809
Query: 2378 ITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQA 2557
++TRLATDA ++ A +L I A++G G+ I+F YGWQ+ L++++ PF+AV
Sbjct: 810 LSTRLATDAAQVQGATGTKLALIAQNTANLGTGIIISFIYGWQLTLLLLSVVPFIAVAGI 869
Query: 2558 LMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNIS 2737
+ MK G+A D KEME AGK A EAIENIRTV +LT + K +++ L P+ ++
Sbjct: 870 VEMKMLAGNAKRDKKEMEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLHGPYRNSVR 929
Query: 2738 KAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFA 2917
KA I G+T+ + + +F+YA FRFG +LI N M ++V+ V AI +G A
Sbjct: 930 KAHIYGITFSISQAFMYFSYAGCFRFGSYLIV--NGHMRFKDVILVFSAIVLGAVALGHA 987
Query: 2918 ASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYP-QLSGEVKLNKVFFRYPERPAVP 3094
+S+ P+Y KA +A +F++ E +P ID + G +P + G V N+V F YP R VP
Sbjct: 988 SSFAPDYAKAKLSAAYLFSLFERQPLIDSYSGEGLWPDKFEGSVTFNEVVFNYPTRANVP 1047
Query: 3095 ILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRK 3274
+LQGL++ VK GQTLALVG SGCGKSTV+ LLER YDP+ G+V +D + +++N + LR
Sbjct: 1048 VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVLLDGQEAKKLNVQWLRA 1107
Query: 3275 HIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGE 3454
+ +VSQEPILFD SI ENI YG H++I A +ANIH FI+ LP Y TRVG+
Sbjct: 1108 QLGIVSQEPILFDCSIAENIAYGDNSRVVPHDEIVRAAKEANIHPFIETLPQKYNTRVGD 1167
Query: 3455 KGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVA 3634
KGTQLSGGQKQRIAIARALIR P++LLLDEATSALDTESEK VQ ALD A + RTCIV+A
Sbjct: 1168 KGTQLSGGQKQRIAIARALIRQPRVLLLDEATSALDTESEKVVQEALDKAREGRTCIVIA 1227
Query: 3635 HRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSSNQS 3778
HRLSTI NA I+V++NG+V E GTH +L+A++G YF++ Q+ Q+
Sbjct: 1228 HRLSTIQNADLIVVIENGKVKEHGTHQQLLAQKGIYFSMVNIQAGTQN 1275
>gi|6981354|ref|NP_036822.1| ATP-binding cassette, sub-family B
(MDR/TAP), member 4; ATP-binding cassette, sub-family B
(MDR/TAP), member 4 (P-glycoprotein 3/ multidrug
resistance 2); ATP-binding cassette sub-family B
(MDR/TAP) member 4 (P-glycoprotein 3/ multidrug
resistance 2); P-glycoprotein 3/ multidrug resistance 2;
ATP-binding cassette sub-family B (MDR/TAP) member 4
(P-glycoprotein 3/ multidrug resistance 2 [Rattus
norvegicus]
gi|1170903|sp|Q08201|MDR2_RAT Multidrug resistance protein 2
(P-glycoprotein 2)
gi|543425|pir||S41646 p-glycoprotein - rat
gi|310193|gb|AAA02937.1| P-glycoprotein
Length = 1278
Score = 1028 bits (2657), Expect = 0.0
Identities = 558/1244 (44%), Positives = 780/1244 (61%), Gaps = 3/1244 (0%)
Frame = +2
Query: 56 LYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFV-TLGTIFLDPNSTASEKA 232
L+RY+ D+L + +G ++ A G GLPLM I+ G ++ FV G L N + S
Sbjct: 42 LFRYSDWQDKLFMLLGTAMAIAHGSGLPLMMIVFGEMTDKFVDNAGNFSLPVNFSLSMLN 101
Query: 233 AARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIA 412
R E+ + Y LG G+ A ++Q S + + + + R++FFH+++RQE+
Sbjct: 102 PGRI-LEEEMTRYAYYYSGLGGGVLLAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEMG 160
Query: 413 WYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSL 592
W+D + L+ +L D++ ++ EG GDKVG+ FQ +A F GF V F W LTL++M++
Sbjct: 161 WFDIKGTTELNTRLTDDISKISEGIGDKVGMFFQAIATFFAGFIVGFIRGWKLTLVIMAI 220
Query: 593 SPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDAL 772
+ + + YA AG +AEE L +IRTVIAF GQ E +RY+ L
Sbjct: 221 TAILGLSTAVWAKILSTFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHL 280
Query: 773 EHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMG 952
E+ KK GIKK+ + F++IYASY LAFW G+ V S G +TVFFS+++G
Sbjct: 281 ENAKKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIG 340
Query: 953 SMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTY 1132
+ ++GQA A GAA ++++ID P+ID++S G P I G + + V F+Y
Sbjct: 341 AFSVGQAAPCIDAFPNARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFSDVHFSY 400
Query: 1133 PTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDF 1312
P+RA++KILKG++L + GQTVALVG+SGCGKST +QLLQR Y+P G I ID I +F
Sbjct: 401 PSRANIKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGTISIDGQDIRNF 460
Query: 1313 NIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEGLN 1492
N++ LR+ +GVVSQEP LF+T+I +NIRYGR +V+ ++I +A+KEANA DFI P+ +
Sbjct: 461 NVRCLREFIGVVSQEPVLFSTTIAENIRYGRGNVTMDEIKKAVKEANAYDFIMKLPQKFD 520
Query: 1493 TLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRT 1672
TLVGDRG Q+SGGQKQRIAIARALVRNPKILLLDEATSALD ESE+ VQ+AL+ A GRT
Sbjct: 521 TLVGDRGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRT 580
Query: 1673 TIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVDDKPKKK 1852
TIVIAHRLSTVRNAD I + G ++E G+H LI+++G+Y LV+ Q + +
Sbjct: 581 TIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELIKKEGIYFRLVNMQTSG---SQILSE 637
Query: 1853 EAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXGAV-KAN 2029
E E +S + + G V ++++ V +
Sbjct: 638 EFEVELSDE--KAAGGVAPNGWKARIFRNSTKKSLKSSRAHQNRLDVETNELDANVPPVS 695
Query: 2030 LFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHFWAL 2209
K+LR + EW Y + GA+ PAFS+ S++I +F D ++ + ++L
Sbjct: 696 FLKVLRLNKTEWPYFVVGTLCAIANGALQPAFSIILSEMIAIFGPGDDTVKQQKCNMFSL 755
Query: 2210 MFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTR 2389
+FL L + Q FG A E LT R+RS ++ +LRQD ++FD K+S G ++TR
Sbjct: 756 VFLGLGVHSFFTFFLQGFTFGKAGEILTTRLRSMAFKAMLRQDMSWFDDHKNSTGALSTR 815
Query: 2390 LATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMK 2569
LATDA ++ A RL I A++G G+ I+F YGWQ+ L++++ PF+AV + MK
Sbjct: 816 LATDAAQVQGATGTRLALIAQNTANLGTGIIISFIYGWQLTLLLLSVVPFIAVAGIVEMK 875
Query: 2570 YHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAII 2749
G+A D KEME AGK A EAIENIRTV +LT + K +++ L P+ ++ KA I
Sbjct: 876 MLAGNAKRDKKEMEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLHGPYRNSVRKAHI 935
Query: 2750 RGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYF 2929
G+T+ + + +F+YA FRFG +LI N M ++V+ V AI +G A+S+
Sbjct: 936 YGITFSISQAFMYFSYAGCFRFGSYLIV--NGHMRFKDVILVFSAIVLGAVALGHASSFA 993
Query: 2930 PEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYP-QLSGEVKLNKVFFRYPERPAVPILQG 3106
P+Y KA +A +F++ E +P ID + G +P + G V N+V F YP R VP+LQG
Sbjct: 994 PDYAKAKLSAAYLFSLFERQPLIDSYSREGMWPDKFEGSVTFNEVVFNYPTRANVPVLQG 1053
Query: 3107 LNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIAL 3286
L++ VK GQTLALVG SGCGKSTV+ LLER YDP+ G V +D + +++N + LR + +
Sbjct: 1054 LSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVLLDGQEAKKLNVQWLRAQLGI 1113
Query: 3287 VSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQ 3466
VSQEPILFD SI +NI YG + ++I A +ANIH FI+ LP YETRVG+KGTQ
Sbjct: 1114 VSQEPILFDCSIAKNIAYGDNSRVVSQDEIVRAAKEANIHPFIETLPQKYETRVGDKGTQ 1173
Query: 3467 LSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLS 3646
LSGGQKQRIAIARALIR P++LLLDEATSALDTESEK VQ ALD A + RTCIV+AHRLS
Sbjct: 1174 LSGGQKQRIAIARALIRQPRVLLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLS 1233
Query: 3647 TIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSSNQS 3778
TI NA I+V+ NG+V E GTH +L+A++G YF++ Q+ Q+
Sbjct: 1234 TIQNADLIVVIDNGKVKEHGTHQQLLAQKGIYFSMVNIQAGTQN 1277
>gi|50732589|ref|XP_418707.1| PREDICTED: similar to ATP-binding
cassette, sub-family B (MDR/TAP), member 1A; multiple
drug resistant 1a [Gallus gallus]
Length = 1734
Score = 1024 bits (2648), Expect = 0.0
Identities = 555/1265 (43%), Positives = 765/1265 (59%), Gaps = 28/1265 (2%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+ + +L+RY VD L++ VG+I + A G GLPLM II G+++ FV G NS+
Sbjct: 109 VGVIELFRYADWVDILLMVVGLIAAAANGTGLPLMIIIFGDMTNAFVLSGV-----NSST 163
Query: 221 SEKAAAR---------AEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFR 373
SE A+ + ++ + YV +G + +Q F++ + ++R R
Sbjct: 164 SEGASVNNSSCQPAPGVDIEADMTKFAYYYVGIGFAVLILSTIQVWTFLIAATRQTSRIR 223
Query: 374 RQFFHSVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAF 553
R+FF +V+ QE+AW+D GTL+ +L D++ + EG GDK+ + Q + F+ G + F
Sbjct: 224 RKFFFAVLHQEMAWFDSTQIGTLNTRLTDDINTIHEGIGDKICIFVQFFSTFLAGITIGF 283
Query: 554 TYDWLLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFN 733
+ W LTL+++S+SP + YA AG +AEEVLT+IRTV+AFN
Sbjct: 284 AHGWKLTLVILSVSPLLAASAAVWSTLLASLTAKELSAYAKAGAVAEEVLTAIRTVVAFN 343
Query: 734 GQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSG--RL 907
GQ+ +Y+ LE + G+KKS L +I+ SY LAFW GT
Sbjct: 344 GQQKALAKYDTNLEAARHVGVKKSITTNTSLGVSQFLIFGSYALAFWYGTKLTVEEPENY 403
Query: 908 ESGTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPS 1087
+ G VL VFFSV++G+ +LGQA ++ A GAA +Y++I++ ID+ S EG P
Sbjct: 404 DIGRVLIVFFSVLIGAFSLGQAAPNLESVANARGAAYEVYQIINKKRLIDSSSKEGYKPD 463
Query: 1088 KISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNP 1267
K+ G I + F+YP+R D+ ILKG++L Q G+T+ALVG+SGCGKST +QLLQRFY+P
Sbjct: 464 KLKGEIEFRNIHFSYPSRPDITILKGLNLKVQTGKTIALVGASGCGKSTTVQLLQRFYDP 523
Query: 1268 DAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKE 1447
D G++ +D I N+K+LR+ +G+VSQEP LF T+I +NIRYGR D+SD +I +A KE
Sbjct: 524 DQGEVTLDGRDIRTLNVKWLRENIGIVSQEPVLFATTIAENIRYGREDISDAEIEQAAKE 583
Query: 1448 ANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESE 1627
ANA DFI P+ NT+VG+RG Q+SGGQKQRIAIARAL RNPKILLLDEATSALD +SE
Sbjct: 584 ANAFDFISRLPDKFNTMVGERGAQLSGGQKQRIAIARALARNPKILLLDEATSALDTQSE 643
Query: 1628 SIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELV 1807
S+VQ+AL+ A GRTTIVIAHRLST+R AD I + G V+E GTH L+ QKG+Y+ LV
Sbjct: 644 SVVQAALDKARTGRTTIVIAHRLSTIRTADTIAAFEKGIVVEQGTHSELMLQKGVYYSLV 703
Query: 1808 HAQVFAD------VDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXX 1969
Q ++ ++ ++ EAE S +N K +
Sbjct: 704 MQQSGSNNVQDDGTSEEDEETEAEEYEENDKSSSVEKLNLKDHFEEPVITGRGSIRRRSS 763
Query: 1970 XXXXXXXXXXXXXXGAVKANL----------FKILRYARPEWIYXXXXXXXXLIQGAVMP 2119
K L +IL +PEW+Y + G V P
Sbjct: 764 RYKSKRSSSKKKSSKKKKKELEEENLPAVPYTRILALNKPEWLYVLLGVIAAAVSGGVHP 823
Query: 2120 AFSLFFSQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMR 2299
AF++ F +II F D ++ K+ +LMFL+L + + + Q +FG + E LTMR
Sbjct: 824 AFAVIFGKIIGAFQERDPERRNKNTLVLSLMFLLLGVITLATYIIQGFMFGKSGEILTMR 883
Query: 2300 IRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGL 2479
+RS ++ +L+Q+ ++D K++ G + TRLATDA +K A RLG + + ++ +
Sbjct: 884 LRSLSFKALLQQEIGWYDDQKNAVGVLLTRLATDASQVKGATGSRLGLMTMTVFTLLTAI 943
Query: 2480 GIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTV 2659
IAF YGWQ+ L++A PF+ A + G A D K +E AG+ + E++ENIRTV
Sbjct: 944 IIAFVYGWQLTLLILACIPFVIAANAANVSSVSGHAAKDQKALEEAGRVSTESVENIRTV 1003
Query: 2660 QALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDK 2839
+LT + Y + + L+ P+ ++ KA + G TYG A S +F AA FRFG +LI
Sbjct: 1004 ASLTREEAFYEKYINSLNGPYRDSLKKAPLYGFTYGIAQSANYFVNAAVFRFGAWLI--A 1061
Query: 2840 NVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSG 3019
L ENV V ++ F+ +G +AS P+Y KA +A IF++L+ +P+ID + G
Sbjct: 1062 RCLTNFENVFIVFSSVIFAAMNVGQSASLAPDYGKAKVSAQRIFHLLDRKPQIDSYSEEG 1121
Query: 3020 -TYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLER 3196
G ++ + F YP RP V +LQGLNV V GQTLALVG SGCGKST I LLER
Sbjct: 1122 EKLSNFEGNIEFRNIHFVYPTRPEVQVLQGLNVKVNKGQTLALVGSSGCGKSTSIQLLER 1181
Query: 3197 LYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQI 3376
YDP+EG V D D + ++ + LR + LVSQEPILFD SI ENI YG + E+I
Sbjct: 1182 FYDPVEGQVLADGFDTKSLHLQWLRSRLGLVSQEPILFDCSIAENIQYGDNNRLVSQEEI 1241
Query: 3377 ETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSA 3556
E A ANIH FID+LP+ Y TRVGEKGTQLSGGQKQRIAIARAL+RNP +LLLDEATSA
Sbjct: 1242 EEAAKAANIHAFIDKLPEKYNTRVGEKGTQLSGGQKQRIAIARALVRNPAVLLLDEATSA 1301
Query: 3557 LDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRG 3736
LDTESEK VQ ALD A + RTCIV+AHRL+TI NA I V++NG+VVEQGTH++L+AK G
Sbjct: 1302 LDTESEKIVQKALDNARQGRTCIVIAHRLTTIQNADIIAVIQNGRVVEQGTHSQLLAKEG 1361
Query: 3737 AYFAL 3751
Y+AL
Sbjct: 1362 HYYAL 1366
Score = 372 bits (954), Expect = e-101
Identities = 226/591 (38%), Positives = 330/591 (55%), Gaps = 9/591 (1%)
Frame = +2
Query: 86 LMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHEVI 265
L + +G+I + +G P ++I G + F E+ R + V+
Sbjct: 806 LYVLLGVIAAAVSGGVHPAFAVIFGKIIGAF--------------QERDPERRNKNTLVL 851
Query: 266 QNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYD--KNTSGT 439
L ++ LG A +Q F E L+ R R F ++++QEI WYD KN G
Sbjct: 852 S--LMFLLLGVITLATYIIQGFMFGKSGEILTMRLRSLSFKALLQQEIGWYDDQKNAVGV 909
Query: 440 LSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGL 619
L +L + +V+ TG ++GL + + +AF Y W LTL++++ PF++
Sbjct: 910 LLTRLATDASQVKGATGSRLGLMTMTVFTLLTAIIIAFVYGWQLTLLILACIPFVIAANA 969
Query: 620 FXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIK 799
AG ++ E + +IRTV + +E ++Y ++L + +K
Sbjct: 970 ANVSSVSGHAAKDQKALEEAGRVSTESVENIRTVASLTREEAFYEKYINSLNGPYRDSLK 1029
Query: 800 KSFLIG-----AGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMAL 964
K+ L G A A++FV F G + V VF SV+ +M +
Sbjct: 1030 KAPLYGFTYGIAQSANYFV-----NAAVFRFGAWLIARCLTNFENVFIVFSSVIFAAMNV 1084
Query: 965 GQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRA 1144
GQ+ G A +A ++ ++DR P+ID+YS EG+ S G I + F YPTR
Sbjct: 1085 GQSASLAPDYGKAKVSAQRIFHLLDRKPQIDSYSEEGEKLSNFEGNIEFRNIHFVYPTRP 1144
Query: 1145 DVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKY 1324
+V++L+G+++ GQT+ALVGSSGCGKST IQLL+RFY+P GQ+L D + ++++
Sbjct: 1145 EVQVLQGLNVKVNKGQTLALVGSSGCGKSTSIQLLERFYDPVEGQVLADGFDTKSLHLQW 1204
Query: 1325 LRQLVGVVSQEPNLFNTSIEQNIRYGRSD--VSDEDIARALKEANAADFIKTFPEGLNTL 1498
LR +G+VSQEP LF+ SI +NI+YG ++ VS E+I A K AN FI PE NT
Sbjct: 1205 LRSRLGLVSQEPILFDCSIAENIQYGDNNRLVSQEEIEEAAKAANIHAFIDKLPEKYNTR 1264
Query: 1499 VGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTI 1678
VG++G Q+SGGQKQRIAIARALVRNP +LLLDEATSALD ESE IVQ AL+NA +GRT I
Sbjct: 1265 VGEKGTQLSGGQKQRIAIARALVRNPAVLLLDEATSALDTESEKIVQKALDNARQGRTCI 1324
Query: 1679 VIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADV 1831
VIAHRL+T++NAD I V++ G+V+E GTH L+ ++G Y+ L DV
Sbjct: 1325 VIAHRLTTIQNADIIAVIQNGRVVEQGTHSQLLAKEGHYYALNTVNYTTDV 1375
Score = 365 bits (936), Expect = 6e-99
Identities = 215/518 (41%), Positives = 301/518 (57%), Gaps = 6/518 (1%)
Frame = +2
Query: 2267 FGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSI 2446
F +AA R T RIR K + VL Q+ +FD + G + TRL D I I ++
Sbjct: 211 FLIAATRQTSRIRRKFFFAVLHQEMAWFDSTQI--GTLNTRLTDDINTIHEGIGDKICIF 268
Query: 2447 FNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKT 2626
++ G+ I F +GW++ +++++ P +A A+ + AG
Sbjct: 269 VQFFSTFLAGITIGFAHGWKLTLVILSVSPLLAASAAVWSTLLASLTAKELSAYAKAGAV 328
Query: 2627 AMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAA 2806
A E + IRTV A Q K + ++L+A + K+I + G + + F +YA A
Sbjct: 329 AEEVLTAIRTVVAFNGQQKALAKYDTNLEAARHVGVKKSITTNTSLGVSQFLIFGSYALA 388
Query: 2807 FRFGLFLIFDKNVLMEPEN-----VLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIF 2971
F +G L + EPEN VL V F++ ++G AA A AA ++
Sbjct: 389 FWYGTKLTVE-----EPENYDIGRVLIVFFSVLIGAFSLGQAAPNLESVANARGAAYEVY 443
Query: 2972 NMLEEEPRIDGMTSSGTYP-QLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALV 3148
++ ++ ID + G P +L GE++ + F YP RP + IL+GLN+ V+ G+T+ALV
Sbjct: 444 QIINKKRLIDSSSKEGYKPDKLKGEIEFRNIHFSYPSRPDITILKGLNLKVQTGKTIALV 503
Query: 3149 GPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRE 3328
G SGCGKST + LL+R YDP +G VT+D D+R +N K LR++I +VSQEP+LF T+I E
Sbjct: 504 GASGCGKSTTVQLLQRFYDPDQGEVTLDGRDIRTLNVKWLRENIGIVSQEPVLFATTIAE 563
Query: 3329 NIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARA 3508
NI YG + + + +IE A +AN FI LPD + T VGE+G QLSGGQKQRIAIARA
Sbjct: 564 NIRYGRE--DISDAEIEQAAKEANAFDFISRLPDKFNTMVGERGAQLSGGQKQRIAIARA 621
Query: 3509 LIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNG 3688
L RNPKILLLDEATSALDT+SE VQ ALD A RT IV+AHRLSTI A I + G
Sbjct: 622 LARNPKILLLDEATSALDTQSESVVQAALDKARTGRTTIVIAHRLSTIRTADTIAAFEKG 681
Query: 3689 QVVEQGTHNELIAKRGAYFALTQKQSSNQSGGAFDTSE 3802
VVEQGTH+EL+ ++G Y++L +QS + + TSE
Sbjct: 682 IVVEQGTHSELMLQKGVYYSLVMQQSGSNNVQDDGTSE 719
>gi|126930|sp|P23174|MDR3_CRIGR Multidrug resistance protein 3
(P-glycoprotein 3)
gi|2119778|pir||I48123 p-glycoprotein isoform III - Chinese hamster
gi|191169|gb|AAA68885.1| p-glycoprotein isoform III
Length = 1281
Score = 1023 bits (2646), Expect = 0.0
Identities = 549/1243 (44%), Positives = 776/1243 (62%), Gaps = 2/1243 (0%)
Frame = +2
Query: 56 LYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVT-LGTIFLDPNSTASEKA 232
L+RY+ D+L + +G I++ A G GLPLM I+ G ++ FV G L N + S
Sbjct: 45 LFRYSDWQDKLFMLLGTIMAIAHGSGLPLMMIVFGEMTDKFVNNAGNFSLPVNFSLSMIN 104
Query: 233 AARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIA 412
R E+ + Y LG G+ A ++Q S + + + + R+ FFH+++RQE+
Sbjct: 105 PGRI-LEEEMTRYAYYYSGLGGGVLVAAYIQVSFWTLAAGRQIKKIRQNFFHAILRQEMG 163
Query: 413 WYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSL 592
W+D + L+ +L D++ ++ EG GDKVG+ FQ +A F GF V F W LTL++M++
Sbjct: 164 WFDIKGTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAI 223
Query: 593 SPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDAL 772
SP + + YA AG +AEE L +IRTVIAF GQ E +RY+ L
Sbjct: 224 SPILGLSAAVWAKILSTFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHL 283
Query: 773 EHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMG 952
E+ KK GIKK+ + F++IYASY LAFW G+ V S G +TVFFS+++G
Sbjct: 284 ENAKKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIG 343
Query: 953 SMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTY 1132
+ ++GQA A GAA ++++ID P+ID++S G P I G + + V F+Y
Sbjct: 344 AFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLDFSDVHFSY 403
Query: 1133 PTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDF 1312
P+RA++KILKG++L Q GQTVALVG+SGCGK+T +QLLQR Y+P G I ID I +F
Sbjct: 404 PSRANIKILKGLNLKVQSGQTVALVGNSGCGKTTTLQLLQRLYDPTEGTISIDGQDIRNF 463
Query: 1313 NIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEGLN 1492
N++YLR+++GVVSQEP LF+T+I +NIRYGR +V+ E+I +A+KEANA +FI P+ +
Sbjct: 464 NVRYLREIIGVVSQEPVLFSTTIAENIRYGRGNVTMEEIKKAVKEANAYEFIMKLPQKFD 523
Query: 1493 TLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRT 1672
TLVG+RG Q+SGGQKQRIAIARALVRNPKILLLDEATSALD ESE+ VQ+AL+ A GRT
Sbjct: 524 TLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRT 583
Query: 1673 TIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVDDKPKKK 1852
TIVIAHRLSTVRNAD I + G ++E G+H L++++G+Y +LV+ Q + +
Sbjct: 584 TIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMQKEGVYFKLVNMQTSG---SQILSQ 640
Query: 1853 EAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXGAVKANL 2032
E E +S + + G + +
Sbjct: 641 EFEVELSEEKA-ADGMTPNGWKSHIFRNSTKKSLKSSRAHHHRLDVDADELDANVPPVSF 699
Query: 2033 FKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHFWALM 2212
K+L+ + EW Y ++ GA+ PA S+ S++I +F D ++ + ++L+
Sbjct: 700 LKVLKLNKTEWPYFVVGTVCAIVNGALQPAISIILSEMIAIFGPGDDAVKQQKCNLFSLV 759
Query: 2213 FLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRL 2392
FL L + + Q FG A E LT R+RS ++ +LRQD ++FD K+S G ++TRL
Sbjct: 760 FLGLGVLSFFTFFLQGFTFGKAGEILTTRLRSMAFKAMLRQDMSWFDDYKNSTGALSTRL 819
Query: 2393 ATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKY 2572
ATD ++ A RL I A++G G+ I+F YGWQ+ L++++ PF+AV + MK
Sbjct: 820 ATDRAQVQGATGTRLALIAQNTANLGTGIIISFIYGWQLTLLLLSVVPFIAVSGIVEMKM 879
Query: 2573 HGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIR 2752
G+A D K +E AGK A EAIENIRTV +LT + K +++ L P+ ++ A I
Sbjct: 880 LAGNAKRDKKALEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLHEPYRNSVQMAHIY 939
Query: 2753 GLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFP 2932
G+T+ + + +F+YA FRFG +LI N M +V+ V AI F +G A+S+ P
Sbjct: 940 GITFSISQAFMYFSYAGCFRFGAYLIV--NGHMRFRDVILVFSAIVFGAVALGHASSFAP 997
Query: 2933 EYIKATFAAGLIFNMLEEEPRIDGMTSSGTYP-QLSGEVKLNKVFFRYPERPAVPILQGL 3109
+Y KA +A +F++ E +P ID + G +P + G V N+V F YP R +P+LQGL
Sbjct: 998 DYAKAKLSAAHLFSLFERQPLIDSYSGEGLWPDKFEGSVTFNEVVFNYPTRANMPVLQGL 1057
Query: 3110 NVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALV 3289
++ VK GQTLALVG SGCGKSTV+ LLER YDP+ G V +D + +++N + LR + +V
Sbjct: 1058 SLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVLLDGQEAKKLNIQWLRAQLGIV 1117
Query: 3290 SQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQL 3469
SQEP+LFD SI ENI YG + ++I A ANIH FI+ LP Y+TRVG+KGTQL
Sbjct: 1118 SQEPVLFDCSIAENIAYGDNSRVVSQDEIVRAAKAANIHPFIETLPQKYKTRVGDKGTQL 1177
Query: 3470 SGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLST 3649
SGGQKQR+AI RALIR P++LLLDEATSALDTESEK VQ ALD A + RTCIV+AHRLST
Sbjct: 1178 SGGQKQRLAIRRALIRQPRVLLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLST 1237
Query: 3650 IVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSSNQS 3778
I NA I+V++NG+V E GTH +L+A++G YF++ Q+ Q+
Sbjct: 1238 IQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVNIQAGAQN 1280
>gi|27656757|gb|AAO20901.1| Mdr3 [Takifugu rubripes]
Length = 1292
Score = 1006 bits (2602), Expect = 0.0
Identities = 548/1267 (43%), Positives = 754/1267 (59%), Gaps = 31/1267 (2%)
Frame = +2
Query: 56 LYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAA 235
L+R+ D ++L G +++ G +PLM I+ G ++ +F+ + + S
Sbjct: 47 LFRFADRWDVVLLISGTVMAMVNGTVMPLMCIVFGEMTDSFIYADMAQHNASGWNSTTTI 106
Query: 236 ARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAW 415
+ ++ + + Y LG + A ++Q S + + + R R FFH +M+QEI+W
Sbjct: 107 LNSTLQEDMQRFAIYYSVLGFVVLLAAYMQVSFWTITAGRQVKRIRSLFFHCIMQQEISW 166
Query: 416 YDKNTSGTLSNKLFD------------------------------NLERVREGTGDKVGL 505
+D N +G L+ +L + ++ +++EG GDKVGL
Sbjct: 167 FDVNDTGELNTRLTEEFPASAFTLCTATLGGVDDLMDVLLFSNGSDVYKIQEGIGDKVGL 226
Query: 506 AFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGG 685
Q FI F + FT W LTL+++++SP + I F YA AG
Sbjct: 227 LIQAYTTFITAFIIGFTTGWKLTLVILAVSPALAISAAFFSKVLASFTSKEQTAYAKAGA 286
Query: 686 IAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCL 865
+AEEVL++IRTV AF+GQ E +RY L K G+KK+ + F++IY SY L
Sbjct: 287 VAEEVLSAIRTVFAFSGQTREIERYHKNLRDAKDVGVKKAISSNIAMGFTFLMIYLSYAL 346
Query: 866 AFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRI 1045
AFW G+ + + G +LTVFF V++G+ ++GQ +A GAA +Y +ID
Sbjct: 347 AFWYGSTLILNFEYTIGNLLTVFFVVLIGAFSVGQTSPNIQNFASARGAAYKVYSIIDNK 406
Query: 1046 PEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCG 1225
P ID++S +G P I G I + F YP+R +VKIL +SL + GQT+ALVGSSGCG
Sbjct: 407 PNIDSFSEDGFKPDFIKGDIEFKNIHFNYPSRPEVKILNNMSLSVKSGQTIALVGSSGCG 466
Query: 1226 KSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGR 1405
KST IQLLQRFY+P+ G + ID I NI+YLR+++GVVSQEP LF T+I +NIRYGR
Sbjct: 467 KSTTIQLLQRFYDPEEGAVFIDGHDIRSLNIRYLREMIGVVSQEPVLFATTITENIRYGR 526
Query: 1406 SDVSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKIL 1585
DV+ E+I RA KE+NA DFI P+ TLVGDRG Q+SGGQKQRIAIARALVRNPKIL
Sbjct: 527 LDVTQEEIERATKESNAYDFIMNLPDKFETLVGDRGTQLSGGQKQRIAIARALVRNPKIL 586
Query: 1586 LLDEATSALDAESESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTH 1765
LLDEATSALDAESE+IVQ+AL+ GRTTIV+AHRLST+RNAD I G+++E GTH
Sbjct: 587 LLDEATSALDAESETIVQAALDKVRLGRTTIVVAHRLSTIRNADIIAGFSNGKIVEQGTH 646
Query: 1766 ETLIEQKGLYHELVHAQVFADVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXX 1945
L+E KG+YH LV Q F +V+ E MS ++ K V +S +
Sbjct: 647 SQLMEIKGVYHGLVTMQTFHNVE------EENTAMSELSAGEKSPVEKTVSQSSI-IRRK 699
Query: 1946 XXXXXXXXXXXXXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAF 2125
+ FK+L PEW Y I GA+ P F
Sbjct: 700 STRGSSFAASEGTKEEKTEEDEDVPDVSFFKVLHLNIPEWPYILVGLICATINGAMQPVF 759
Query: 2126 SLFFSQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIR 2305
++ FS+II VF++PDRD +++ F +LMF+V+ V +M Q FG + E LT+++R
Sbjct: 760 AILFSKIITVFADPDRDSVRRKSEFISLMFVVIGCVSFVTMFLQGYCFGKSGEILTLKLR 819
Query: 2306 SKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGI 2485
+ + ++RQD +++D P+++ G +TTRLA DA ++ A RL +I A++G + I
Sbjct: 820 LRAFTAMMRQDLSWYDNPQNTVGALTTRLAADAAQVQGAAGVRLATIMQNFANLGTSIII 879
Query: 2486 AFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQA 2665
AF YGW++ L++A+ P +A A +K G A D KE+E AGK A EAIEN+RTV +
Sbjct: 880 AFVYGWELTLLILAVVPLIAAAGAAEIKLLAGHAAKDKKELEKAGKIATEAIENVRTVVS 939
Query: 2666 LTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNV 2845
L+ + K ++ +L P+ + KA + GLTY F+ ++ +F YAA FRFG +LI +
Sbjct: 940 LSREPKFECLYEENLRVPYKNSQKKAHVYGLTYSFSQAMIYFAYAACFRFGAWLI--EAG 997
Query: 2846 LMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTY 3025
M+ E V V+ A+ + +G A ++ P Y KA AA + ++ ++P ID ++ GT
Sbjct: 998 RMDVEGVFLVVSAVLYGAMAVGEANTFAPNYAKAKMAASYLMMLINKKPAIDNLSEEGTS 1057
Query: 3026 PQ-LSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLY 3202
P+ G V V F YP RP V ILQGLN+ VK G+TLALVG SGCGKST I LLER Y
Sbjct: 1058 PEKYDGNVHFEGVKFNYPSRPDVTILQGLNLKVKKGETLALVGSSGCGKSTTIQLLERFY 1117
Query: 3203 DPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIET 3382
DP EG V++D +++Q+N LR I +VSQEP+LFD S+ ENI YG + ++I
Sbjct: 1118 DPREGRVSLDGVNVKQLNIHWLRSQIGIVSQEPVLFDCSLAENIAYGDNSRSVSMDEIR- 1176
Query: 3383 ACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALD 3562
Y+T+ G+KGTQLSGGQKQR+AIARA+IRNPK+LLLDEATSALD
Sbjct: 1177 -----------------YDTQAGDKGTQLSGGQKQRVAIARAIIRNPKLLLLDEATSALD 1219
Query: 3563 TESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAY 3742
TESEK VQ ALD A K RTCIVVAHRLSTI NA CI V + G VVE+GTH +LIAK+G Y
Sbjct: 1220 TESEKVVQEALDQARKGRTCIVVAHRLSTIQNADCIAVFQGGVVVEKGTHQQLIAKKGVY 1279
Query: 3743 FALTQKQ 3763
L KQ
Sbjct: 1280 HMLVTKQ 1286
Score = 379 bits (973), Expect = e-103
Identities = 223/579 (38%), Positives = 338/579 (57%), Gaps = 3/579 (0%)
Frame = +2
Query: 92 LAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHEVIQN 271
+ VG+I + G P+ +I+ + T+F DP+ + + ++EF
Sbjct: 742 ILVGLICATINGAMQPVFAILFSKII-------TVFADPDRDSVRR---KSEFIS----- 786
Query: 272 CLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYD--KNTSGTLS 445
L +V +GC F FLQ CF E L+ + R + F ++MRQ+++WYD +NT G L+
Sbjct: 787 -LMFVVIGCVSFVTMFLQGYCFGKSGEILTLKLRLRAFTAMMRQDLSWYDNPQNTVGALT 845
Query: 446 NKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFX 625
+L + +V+ G ++ Q A +AF Y W LTL+++++ P + G
Sbjct: 846 TRLAADAAQVQGAAGVRLATIMQNFANLGTSIIIAFVYGWELTLLILAVVPLIAAAGAAE 905
Query: 626 XXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQ-EYECKRYEDALEHGKKTGIKK 802
+ AG IA E + ++RTV++ + + ++EC YE+ L K KK
Sbjct: 906 IKLLAGHAAKDKKELEKAGKIATEAIENVRTVVSLSREPKFECL-YEENLRVPYKNSQKK 964
Query: 803 SFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQ 982
+ + G + +IY +Y F G + +GR++ V V +V+ G+MA+G+A
Sbjct: 965 AHVYGLTYSFSQAMIYFAYAACFRFGAWLIEAGRMDVEGVFLVVSAVLYGAMAVGEANTF 1024
Query: 983 FATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILK 1162
A AA+ L +I++ P ID S EG +P K G + V+F YP+R DV IL+
Sbjct: 1025 APNYAKAKMAASYLMMLINKKPAIDNLSEEGTSPEKYDGNVHFEGVKFNYPSRPDVTILQ 1084
Query: 1163 GVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVG 1342
G++L + G+T+ALVGSSGCGKST IQLL+RFY+P G++ +D + ++ NI +LR +G
Sbjct: 1085 GLNLKVKKGETLALVGSSGCGKSTTIQLLERFYDPREGRVSLDGVNVKQLNIHWLRSQIG 1144
Query: 1343 VVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQM 1522
+VSQEP LF+ S+ +NI YG D +R++ + D I+ +T GD+G Q+
Sbjct: 1145 IVSQEPVLFDCSLAENIAYG-------DNSRSV----SMDEIR-----YDTQAGDKGTQL 1188
Query: 1523 SGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLST 1702
SGGQKQR+AIARA++RNPK+LLLDEATSALD ESE +VQ AL+ A +GRT IV+AHRLST
Sbjct: 1189 SGGQKQRVAIARAIIRNPKLLLLDEATSALDTESEKVVQEALDQARKGRTCIVVAHRLST 1248
Query: 1703 VRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQV 1819
++NAD I V + G V+E GTH+ LI +KG+YH LV Q+
Sbjct: 1249 IQNADCIAVFQGGVVVEKGTHQQLIAKKGVYHMLVTKQM 1287
Score = 365 bits (936), Expect = 6e-99
Identities = 221/604 (36%), Positives = 325/604 (53%), Gaps = 47/604 (7%)
Frame = +2
Query: 2096 LIQGAVMPAFSLFFSQIINVFSNPDRDQ----------------MKKDGHFWALMFLVLA 2227
++ G VMP + F ++ + F D Q +++D +A+ + VL
Sbjct: 67 MVNGTVMPLMCIVFGEMTDSFIYADMAQHNASGWNSTTTILNSTLQEDMQRFAIYYSVLG 126
Query: 2228 AVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAP 2407
V + Q S + + A R RIRS + +++Q+ ++FD+ + G + TRL + P
Sbjct: 127 FVVLLAAYMQVSFWTITAGRQVKRIRSLFFHCIMQQEISWFDV--NDTGELNTRLTEEFP 184
Query: 2408 ------------------------------NIKSAIDYRLGSIFNAIASVGGGLGIAFYY 2497
I+ I ++G + A + I F
Sbjct: 185 ASAFTLCTATLGGVDDLMDVLLFSNGSDVYKIQEGIGDKVGLLIQAYTTFITAFIIGFTT 244
Query: 2498 GWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQ 2677
GW++ +++A+ P +A+ A K + + AG A E + IRTV A + Q
Sbjct: 245 GWKLTLVILAVSPALAISAAFFSKVLASFTSKEQTAYAKAGAVAEEVLSAIRTVFAFSGQ 304
Query: 2678 TKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEP 2857
T+ + +L + KAI + GF + + +YA AF +G LI + +
Sbjct: 305 TREIERYHKNLRDAKDVGVKKAISSNIAMGFTFLMIYLSYALAFWYGSTLILNFEYTIG- 363
Query: 2858 ENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-L 3034
N+L V F + ++G + + A AA ++++++ +P ID + G P +
Sbjct: 364 -NLLTVFFVVLIGAFSVGQTSPNIQNFASARGAAYKVYSIIDNKPNIDSFSEDGFKPDFI 422
Query: 3035 SGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLE 3214
G+++ + F YP RP V IL +++ VK GQT+ALVG SGCGKST I LL+R YDP E
Sbjct: 423 KGDIEFKNIHFNYPSRPEVKILNNMSLSVKSGQTIALVGSSGCGKSTTIQLLQRFYDPEE 482
Query: 3215 GAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSK 3394
GAV +D +D+R +N ++LR+ I +VSQEP+LF T+I ENI YG + T E+IE A +
Sbjct: 483 GAVFIDGHDIRSLNIRYLREMIGVVSQEPVLFATTITENIRYGRL--DVTQEEIERATKE 540
Query: 3395 ANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESE 3574
+N + FI LPD +ET VG++GTQLSGGQKQRIAIARAL+RNPKILLLDEATSALD ESE
Sbjct: 541 SNAYDFIMNLPDKFETLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAESE 600
Query: 3575 KQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALT 3754
VQ ALD RT IVVAHRLSTI NA I NG++VEQGTH++L+ +G Y L
Sbjct: 601 TIVQAALDKVRLGRTTIVVAHRLSTIRNADIIAGFSNGKIVEQGTHSQLMEIKGVYHGLV 660
Query: 3755 QKQS 3766
Q+
Sbjct: 661 TMQT 664
>gi|39595370|emb|CAE60408.1| Hypothetical protein CBG04013
[Caenorhabditis briggsae]
Length = 1265
Score = 1002 bits (2591), Expect = 0.0
Identities = 529/1253 (42%), Positives = 771/1253 (61%), Gaps = 15/1253 (1%)
Frame = +2
Query: 50 FQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFV-------TLGTIFLDP 208
+ L+ YT D ++L VG I + G G PL++I++G ++ F+ +G ++P
Sbjct: 36 YGLFSYTRGKDLILLIVGTIAAVIHGAGFPLLAIVLGGMTTVFLRAQNSDFVVGVGNVNP 95
Query: 209 NSTASEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFH 388
N + + EF+ EV++ C+ Y+ LG +F ++Q +CF E L ++ R+ +
Sbjct: 96 NGL---EPISIDEFNSEVVKYCIYYLILGVAMFVTSYVQIACFESYAENLVHKLRQNYLK 152
Query: 389 SVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWL 568
+++RQ+I W+DK +G L+ +L D+LERVREG GDK L QM A F+ G+ V F Y W
Sbjct: 153 AILRQQIQWFDKQQTGNLTARLTDDLERVREGLGDKFALLVQMFAAFLAGYGVGFFYSWS 212
Query: 569 LTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYE 748
+TL+MM +P +++ G YAVAG IAEE +SIRTV + NG + E
Sbjct: 213 MTLVMMGFAPLIVLSGAKMSKSMATRTKVEQETYAVAGAIAEETFSSIRTVHSLNGHKRE 272
Query: 749 CKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSG-RLESGTVL 925
R+ +ALE+G+KTGI K +G G+ + +Y+SY LAFW G+ + + + G +
Sbjct: 273 LDRFWNALENGRKTGIVKYCYMGIGVGFSNLCMYSSYALAFWYGSTLIINDPTFDRGLIF 332
Query: 926 TVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRI 1105
TVFF+V+ GS +LG A A+ GTA GAA ++ VI+ P+ID YS EG + G I
Sbjct: 333 TVFFAVLSGSTSLGGALPHLASFGTARGAAYTVLRVINSHPKIDPYSLEGLLVDNMKGDI 392
Query: 1106 SVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQIL 1285
S V F YP+R D+ +LKG+SL+ + G+ +ALVGSSGCGKSTI+ LLQRFY+P G++
Sbjct: 393 SFQNVHFRYPSRKDIPVLKGISLEVKSGEKIALVGSSGCGKSTIVNLLQRFYDPTKGKVS 452
Query: 1286 IDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADF 1465
ID + +++ N+ LR+ +G+VSQEP LF+ +I +NI+ G + + + A K ANA DF
Sbjct: 453 IDGVDLKEINVHSLREQIGIVSQEPVLFDGTIYENIKMGNEHATHDQVVEACKMANANDF 512
Query: 1466 IKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSA 1645
IK P+G T VG++GVQ+SGGQKQRIAIARALV+NPKILLLDEATSALD E+E VQ+A
Sbjct: 513 IKRLPDGYGTRVGEKGVQLSGGQKQRIAIARALVKNPKILLLDEATSALDTEAEREVQAA 572
Query: 1646 LENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFA 1825
L+ A GRTT+++AHRLST+RN DKI V KAG ++E G+HE L+ ++G+++++ AQV
Sbjct: 573 LDQAQAGRTTLIVAHRLSTIRNVDKIFVFKAGNIVETGSHEELMNKQGVFYDMTQAQVVR 632
Query: 1826 DVDDKPKK-------KEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXX 1984
+ K + A +SR++S R +++ T Q+
Sbjct: 633 QQQQEAGKDIEDTISESAHSHLSRKSSTRS-AISMATSIHQL------------------ 673
Query: 1985 XXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSN 2164
A + KI + R + + I G+V P F+L +++I NV+S
Sbjct: 674 --AEEVEECKAPPTPISKIFNFNRDKIWWFIGGMFGAFIFGSVTPVFALVYAEIFNVYSE 731
Query: 2165 PDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDAT 2344
P +QM+ D +FW MF+++ + G E LTM++R + ++N++RQD
Sbjct: 732 PV-EQMQSDVYFWCGMFVLMGITFFIGFFISANCLGRCGESLTMKLRFEAFKNLMRQDIA 790
Query: 2345 YFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVM 2524
++D +H G++ TR ATDAPN++ RL + +I ++ G LGI FYYGWQ+A +++
Sbjct: 791 FYDDLRHGTGKLCTRFATDAPNVRYVFT-RLPVVLASIVTILGALGIGFYYGWQLALILV 849
Query: 2525 AIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCS 2704
+ P + +G M+ G D + +E AGK A +A+E+IRTV +L Q + + +C
Sbjct: 850 VMVPLLVMGGYFEMQMRFGKQIRDTQLLEEAGKVASQAVEHIRTVHSLNRQEQFHFTYCE 909
Query: 2705 HLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFA 2884
+L P N+ A G + F+ S+ FF YA AF G IF M+P +V RV FA
Sbjct: 910 YLREPFNTNLKHAHTYGAVFAFSQSLIFFMYAVAFYLGS--IFVNQHSMQPIDVYRVFFA 967
Query: 2885 ISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVF 3064
ISF IG S+ P+ +KA AA L+F ++E ID ++ +G ++G + + +F
Sbjct: 968 ISFCGQMIGNTTSFIPDVVKARLAASLLFYLIEHPTPIDSLSEAGIVKPITGNISIRNIF 1027
Query: 3065 FRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDL 3244
F YP R +LQG + +KPGQT+ALVG SGCGKST++ LLER Y+ +G + +D +++
Sbjct: 1028 FNYPTRKETKVLQGFTIDIKPGQTVALVGHSGCGKSTIMGLLERFYNQDKGMIMIDGDNI 1087
Query: 3245 RQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDEL 3424
R +N LR+ + +VSQEP LFD +I ENI YG T+++I A ANIH FI L
Sbjct: 1088 RNLNISSLRQQVCIVSQEPTLFDCTIGENICYGTNRN-VTYQEIVEAAKMANIHNFILGL 1146
Query: 3425 PDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAA 3604
PDGY+T VGEKGTQLSGGQKQRIAIARAL+R+P +LLLDEATSALDTESEK VQ ALDAA
Sbjct: 1147 PDGYDTHVGEKGTQLSGGQKQRIAIARALVRSPSVLLLDEATSALDTESEKIVQEALDAA 1206
Query: 3605 AKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQ 3763
+ RTC+V+AHRLSTI N+ I +V G++V++GTH+EL+ K Y L + Q
Sbjct: 1207 KQGRTCLVIAHRLSTIQNSDVIAIVSEGKIVDKGTHDELMRKSEIYQKLCETQ 1259
Score = 376 bits (965), Expect = e-102
Identities = 210/556 (37%), Positives = 309/556 (54%), Gaps = 3/556 (0%)
Frame = +2
Query: 2174 DQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFD 2353
D+ + + + +L+L + Q + F AE L ++R + +LRQ +FD
Sbjct: 104 DEFNSEVVKYCIYYLILGVAMFVTSYVQIACFESYAENLVHKLRQNYLKAILRQQIQWFD 163
Query: 2354 MPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIF 2533
K G +T RL D ++ + + + A+ G G+ F+Y W M ++M
Sbjct: 164 --KQQTGNLTARLTDDLERVREGLGDKFALLVQMFAAFLAGYGVGFFYSWSMTLVMMGFA 221
Query: 2534 PFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLD 2713
P + + A M K + + AG A E +IRTV +L + + F + L+
Sbjct: 222 PLIVLSGAKMSKSMATRTKVEQETYAVAGAIAEETFSSIRTVHSLNGHKRELDRFWNALE 281
Query: 2714 APHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISF 2893
I K G+ GF+N + +YA AF +G LI + + + + V FA+
Sbjct: 282 NGRKTGIVKYCYMGIGVGFSNLCMYSSYALAFWYGSTLIIN-DPTFDRGLIFTVFFAVLS 340
Query: 2894 SFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTY-PQLSGEVKLNKVFFR 3070
++G A + + A AA + ++ P+ID + G + G++ V FR
Sbjct: 341 GSTSLGGALPHLASFGTARGAAYTVLRVINSHPKIDPYSLEGLLVDNMKGDISFQNVHFR 400
Query: 3071 YPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQ 3250
YP R +P+L+G+++ VK G+ +ALVG SGCGKST+++LL+R YDP +G V++D DL++
Sbjct: 401 YPSRKDIPVLKGISLEVKSGEKIALVGSSGCGKSTIVNLLQRFYDPTKGKVSIDGVDLKE 460
Query: 3251 MNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPD 3430
+N LR+ I +VSQEP+LFD +I ENI G + TH+Q+ AC AN + FI LPD
Sbjct: 461 INVHSLREQIGIVSQEPVLFDGTIYENIKMGNEHA--THDQVVEACKMANANDFIKRLPD 518
Query: 3431 GYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAK 3610
GY TRVGEKG QLSGGQKQRIAIARAL++NPKILLLDEATSALDTE+E++VQ ALD A
Sbjct: 519 GYGTRVGEKGVQLSGGQKQRIAIARALVKNPKILLLDEATSALDTEAEREVQAALDQAQA 578
Query: 3611 DRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQ--SSNQSGG 3784
RT ++VAHRLSTI N I V K G +VE G+H EL+ K+G ++ +TQ Q Q
Sbjct: 579 GRTTLIVAHRLSTIRNVDKIFVFKAGNIVETGSHEELMNKQGVFYDMTQAQVVRQQQQEA 638
Query: 3785 AFDTSEALXXXXXXHV 3832
D + + H+
Sbjct: 639 GKDIEDTISESAHSHL 654
>gi|25297453|pir||D87789 protein C34G6.4 [imported] - Caenorhabditis
elegans
Length = 1289
Score = 999 bits (2584), Expect = 0.0
Identities = 531/1259 (42%), Positives = 771/1259 (61%), Gaps = 17/1259 (1%)
Frame = +2
Query: 50 FQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGT----IFLDPNST 217
+ ++ YT VD L+L G + + G G PL++I++G ++ F+ + +D +
Sbjct: 36 YGIFYYTQGVDLLLLITGTVAAVIHGAGFPLLAIVLGGMTTVFLRAQNSDFVVGVDNVNP 95
Query: 218 ASEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVM 397
+ EF+ EV++ C+ Y+ LG +F ++Q +CF E+L ++ R+ + +++
Sbjct: 96 EGLVPISLDEFNSEVVKYCIYYLVLGVLMFFTSYVQIACFESYAERLVHKLRQNYLKAIL 155
Query: 398 RQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
RQ+I W+DK +G L+ +L D+LERVREG GDK L QM A F+ G+ V F Y W +TL
Sbjct: 156 RQQIQWFDKQQTGNLTARLTDDLERVREGLGDKFALLVQMFAAFLAGYGVGFFYSWSMTL 215
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
+MM +P +++ G YAVAG IAEE +SIRTV + NG + E R
Sbjct: 216 VMMGFAPLIVLSGAKMSKSMATRTRVEQETYAVAGAIAEETFSSIRTVHSLNGHKRELDR 275
Query: 758 YEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSG-RLESGTVLTVF 934
+ +ALE G++TGI K +G G+ + +Y+SY LAFW G+ + + + G + TVF
Sbjct: 276 FYNALEVGRQTGIVKYCYMGIGVGFSNLCMYSSYALAFWYGSTLIINDPTFDRGLIFTVF 335
Query: 935 FSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVN 1114
F+V+ GS +LG A A+ GTA GAA+++ VI+ P+ID YS EG + G IS
Sbjct: 336 FAVLSGSTSLGGALPHLASFGTARGAASTVLRVINSHPKIDPYSLEGILVDNMKGDISFK 395
Query: 1115 KVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDD 1294
V F YP+R D+ +LKG+SL+ + G +ALVGSSGCGKSTI+ LLQRFY+P G++LID
Sbjct: 396 DVHFRYPSRKDIHVLKGISLELKAGDKIALVGSSGCGKSTIVNLLQRFYDPTKGRVLIDG 455
Query: 1295 IPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKT 1474
+ + + N+ LR+ +G+VSQEP LF+ +I +NI+ G + + + A K ANA DFIK
Sbjct: 456 VDLREVNVHSLREQIGIVSQEPVLFDGTIYENIKMGNEHATHDQVVEACKMANANDFIKR 515
Query: 1475 FPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALEN 1654
P+G T VG++GVQ+SGGQKQRIAIARALV+NPKILLLDEATSALD E+E VQ AL+
Sbjct: 516 LPDGYGTRVGEKGVQLSGGQKQRIAIARALVKNPKILLLDEATSALDTEAEREVQGALDQ 575
Query: 1655 ASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVD 1834
A GRTTI++AHRLST+RN D+I V KAG ++E G+HE L+ ++G+++++ AQV
Sbjct: 576 AQAGRTTIIVAHRLSTIRNVDRIFVFKAGNIVESGSHEELMSKQGIFYDMTQAQVVRQQQ 635
Query: 1835 DKPKK-------KEAERRMSRQTSQRKG---SVNFKTQESQVDXXXXXXXXXXXXXXXXX 1984
+ K + A +SR++S R + + +V+
Sbjct: 636 QEAGKDIEDTISESAHSHLSRKSSTRSAISIATSIHQLAEEVELIDPFNGQTNQDVIRSR 695
Query: 1985 XXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSN 2164
A ++FKI ++ + + I G+V P F+L +++I NV+S
Sbjct: 696 ILSAFGGECKAPPTSMFKIFKFNGDKVGWFIGGIFGAFIFGSVTPVFALVYAEIFNVYSL 755
Query: 2165 PDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDAT 2344
P DQM+ + +FW MF+++ + G E LTM++R + ++N+LRQD
Sbjct: 756 P-ADQMQANVYFWCGMFVLMGITFFVGFFTSANCLGRCGESLTMKLRFEAFKNLLRQDIA 814
Query: 2345 YFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVM 2524
++D +H G++ TR ATDAPN++ RL + +I ++ G LGI FYYGWQ+A +++
Sbjct: 815 FYDDLRHGTGKLCTRFATDAPNVRYVFT-RLPVVLASIVTICGALGIGFYYGWQLALILV 873
Query: 2525 AIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCS 2704
+ P + +G M+ G D + +E AGK A +A+E+IRTV +L Q + + +C
Sbjct: 874 VMVPLLVMGGYFEMQMRFGKQIRDTQLLEEAGKVASQAVEHIRTVHSLNRQEQFHFTYCE 933
Query: 2705 HLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFA 2884
+L P N+ A G + F+ S+ FF YAAAF G IF M+P +V RV FA
Sbjct: 934 YLREPFNTNLKHAHTYGAVFAFSQSLIFFMYAAAFYLG--SIFVNQQAMQPIDVYRVFFA 991
Query: 2885 ISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVF 3064
ISF IG S+ P+ +KA AA L+F ++E ID ++ SG ++G + + VF
Sbjct: 992 ISFCGQMIGNTTSFIPDVVKARLAASLLFYLIEHPTPIDSLSDSGIVKPITGNISIRNVF 1051
Query: 3065 FRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDL 3244
F YP R +LQG + +K G+T+ALVG SGCGKST++ LLER Y+ +G + +D +++
Sbjct: 1052 FNYPTRKDTKVLQGFTLDIKAGKTVALVGHSGCGKSTIMGLLERFYNQDKGMIMIDGDNI 1111
Query: 3245 RQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDEL 3424
R +N LR+ + +VSQEP LFD +I ENI YG T+++I A ANIH FI L
Sbjct: 1112 RNLNISSLREQVCIVSQEPTLFDCTIGENICYGTN-RNVTYQEIVEAAKMANIHNFILGL 1170
Query: 3425 PDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAA 3604
PDGY+T VGEKGTQLSGGQKQRIAIARAL+R+P +LLLDEATSALDTESEK VQ ALDAA
Sbjct: 1171 PDGYDTHVGEKGTQLSGGQKQRIAIARALVRSPSVLLLDEATSALDTESEKIVQEALDAA 1230
Query: 3605 AKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAY--FALTQKQSSNQ 3775
+ RTC+V+AHRLSTI N+ I +V G++VE+GTH+ELI K Y F TQ+ +Q
Sbjct: 1231 KQGRTCLVIAHRLSTIQNSDVIAIVSEGKIVEKGTHDELIRKSEIYQKFCETQRIVESQ 1289
>gi|72475|pir||DVMS1A multidrug resistance protein 1a - mouse
(fragment)
gi|200330|gb|AAA03243.1| mdr1a protein
Length = 1104
Score = 998 bits (2581), Expect = 0.0
Identities = 527/1109 (47%), Positives = 720/1109 (64%), Gaps = 6/1109 (0%)
Frame = +2
Query: 458 DNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXXXXX 637
D++ ++ EG GDK+G+ FQ MA F GGF + FT W LTL+++++SP + +
Sbjct: 1 DDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKIL 60
Query: 638 XXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFLIG 817
YA AG +AEEVL +IRTVIAF GQ+ E +RY + LE K+ GIKK+
Sbjct: 61 SSFTDKELHAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEAKRLGIKKAITAN 120
Query: 818 AGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQFATIG 997
+ + F++IYASY LAFW GT+ V S G VLTVFFSV++G+ ++GQA
Sbjct: 121 ISMGAAFLLIYASYALAFWYGTSLVISKEYSIGQVLTVFFSVLIGAFSVGQASPNIEAFA 180
Query: 998 TALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKGVSLD 1177
A GAA ++++ID P ID++S G P I G + + F+YP+R +V+ILKG++L
Sbjct: 181 NARGAAYEVFKIIDNKPSIDSFSKSGHKPDNIQGNLEFKNIHFSYPSRKEVQILKGLNLK 240
Query: 1178 AQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQE 1357
+ GQTVALVG+SGCGKST +QL+QR Y+P G + ID I N++YLR+++GVVSQE
Sbjct: 241 VKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRYLREIIGVVSQE 300
Query: 1358 PNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQK 1537
P LF T+I +NIRYGR DV+ ++I +A+KEANA DFI P +TLVG+RG +SGGQK
Sbjct: 301 PVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPHQFDTLVGERGAHVSGGQK 360
Query: 1538 QRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLSTVRNAD 1717
QRIAIARALVRNPKILLLDEATSALD ESE++VQ+AL+ A GRTTIVIAHRLSTVRNAD
Sbjct: 361 QRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNAD 420
Query: 1718 KIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFA---DVDDKPKKKEAERRMSRQTSQ 1888
I G ++E G H+ L+ +KG+Y +LV Q ++ ++ K + E +S+
Sbjct: 421 VIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTAGNEIELGNEACKSKDEIDNLDMSSK 480
Query: 1889 RKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXGAVKANLFKILRYARPEWI 2068
GS S + A+ ++IL+ EW
Sbjct: 481 DSGS-------SLIRRRSTRKSICGPHDQDRKLSTKEALDEDVPPASFWRILKLNSTEWP 533
Query: 2069 YXXXXXXXXLIQGAVMPAFSLFFSQIINVFSN--PDRDQMKKDGHFWALMFLVLAAVQGT 2242
Y +I G + PAFS+ FS+++ VF+N P Q +++ + ++L+FL+L +
Sbjct: 534 YFVVGIFCAIINGGLQPAFSVIFSKVVGVFTNGGPPETQ-RQNSNLFSLLFLILGIISFI 592
Query: 2243 SMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSA 2422
+ Q FG A E LT R+R V++++LRQD ++FD PK++ G +TTRLA DA +K A
Sbjct: 593 TFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGA 652
Query: 2423 IDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAK 2602
RL IF IA++G G+ I+ YGWQ+ L++AI P +A+ + MK G A D K
Sbjct: 653 TGSRLAVIFQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKK 712
Query: 2603 EMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSI 2782
E+E +GK A EAIEN RTV +LT + K ++ L P+ + KA + G+T+ F ++
Sbjct: 713 ELEGSGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNAMKKAHVFGITFSFTQAM 772
Query: 2783 QFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAG 2962
+F+YAA FRFG +L+ + LM ENVL V AI F +G +S+ P+Y KAT +A
Sbjct: 773 MYFSYAACFRFGAYLVTQQ--LMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKATVSAS 830
Query: 2963 LIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTL 3139
I ++E+ P ID ++ G P L G V+ + V F YP RP++P+LQGL++ VK GQTL
Sbjct: 831 HIIRIIEKTPEIDSYSTQGLKPNMLEGNVQFSGVVFNYPTRPSIPVLQGLSLEVKKGQTL 890
Query: 3140 ALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTS 3319
ALVG SGCGKSTV+ LLER YDP+ G+V +D +++Q+N + LR + +VSQEPILFD S
Sbjct: 891 ALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAQLGIVSQEPILFDCS 950
Query: 3320 IRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAI 3499
I ENI YG ++E+I A +ANIH+FID LPD Y TRVG+KGTQLSGGQKQRIAI
Sbjct: 951 IAENIAYGDNSRVVSYEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAI 1010
Query: 3500 ARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVV 3679
ARAL+R P ILLLDEATSALDTESEK VQ ALD A + RTCIV+AHRLSTI NA I+V+
Sbjct: 1011 ARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVI 1070
Query: 3680 KNGQVVEQGTHNELIAKRGAYFALTQKQS 3766
+NG+V E GTH +L+A++G YF++ Q+
Sbjct: 1071 QNGKVKEHGTHQQLLAQKGIYFSMVSVQA 1099
Score = 411 bits (1057), Expect = e-113
Identities = 234/580 (40%), Positives = 341/580 (58%), Gaps = 4/580 (0%)
Frame = +2
Query: 98 VGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHEVIQNCL 277
VGI + G P S+I V F G P T + + FS L
Sbjct: 537 VGIFCAIINGGLQPAFSVIFSKVVGVFTNGG-----PPETQRQNSNL---FS-------L 581
Query: 278 KYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYD--KNTSGTLSNK 451
++ LG F FLQ F E L+ R R F S++RQ+++W+D KNT+G L+ +
Sbjct: 582 LFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTR 641
Query: 452 LFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXXX 631
L ++ +V+ TG ++ + FQ +A G ++ Y W LTL+++++ P + I G+
Sbjct: 642 LANDAAQVKGATGSRLAVIFQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMK 701
Query: 632 XXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFL 811
+ +G IA E + + RTV++ ++ Y +L+ + +KK+ +
Sbjct: 702 MLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNAMKKAHV 761
Query: 812 IGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQFAT 991
G + ++Y SY F G V + VL VF +++ G+MA+GQ
Sbjct: 762 FGITFSFTQAMMYFSYAACFRFGAYLVTQQLMTFENVLLVFSAIVFGAMAVGQVSSFAPD 821
Query: 992 IGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKGVS 1171
A +A+ + +I++ PEID+YST+G P+ + G + + V F YPTR + +L+G+S
Sbjct: 822 YAKATVSASHIIRIIEKTPEIDSYSTQGLKPNMLEGNVQFSGVVFNYPTRPSIPVLQGLS 881
Query: 1172 LDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVS 1351
L+ + GQT+ALVGSSGCGKST++QLL+RFY+P AG + +D I+ N+++LR +G+VS
Sbjct: 882 LEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAQLGIVS 941
Query: 1352 QEPNLFNTSIEQNIRYGRSD--VSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQMS 1525
QEP LF+ SI +NI YG + VS E+I RA KEAN FI + P+ NT VGD+G Q+S
Sbjct: 942 QEPILFDCSIAENIAYGDNSRVVSYEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLS 1001
Query: 1526 GGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLSTV 1705
GGQKQRIAIARALVR P ILLLDEATSALD ESE +VQ AL+ A GRT IVIAHRLST+
Sbjct: 1002 GGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTI 1061
Query: 1706 RNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFA 1825
+NAD I+V++ G+V E GTH+ L+ QKG+Y +V Q A
Sbjct: 1062 QNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQAGA 1101
Score = 350 bits (897), Expect = 2e-94
Identities = 196/458 (42%), Positives = 277/458 (59%), Gaps = 1/458 (0%)
Frame = +2
Query: 2399 DAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHG 2578
D I I ++G F A+A+ GG I F GW++ +++AI P + + + K
Sbjct: 2 DVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKILS 61
Query: 2579 GSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGL 2758
+ AG A E + IRTV A Q K + ++L+ I KAI +
Sbjct: 62 SFTDKELHAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEAKRLGIKKAITANI 121
Query: 2759 TYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEY 2938
+ G A + + +YA AF +G L+ K + VL V F++ ++G A+ +
Sbjct: 122 SMGAAFLLIYASYALAFWYGTSLVISKEYSIG--QVLTVFFSVLIGAFSVGQASPNIEAF 179
Query: 2939 IKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKLNKVFFRYPERPAVPILQGLNV 3115
A AA +F +++ +P ID + SG P + G ++ + F YP R V IL+GLN+
Sbjct: 180 ANARGAAYEVFKIIDNKPSIDSFSKSGHKPDNIQGNLEFKNIHFSYPSRKEVQILKGLNL 239
Query: 3116 HVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQ 3295
VK GQT+ALVG SGCGKST + L++RLYDPL+G V++D D+R +N ++LR+ I +VSQ
Sbjct: 240 KVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRYLREIIGVVSQ 299
Query: 3296 EPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSG 3475
EP+LF T+I ENI YG + + T ++IE A +AN + FI +LP ++T VGE+G +SG
Sbjct: 300 EPVLFATTIAENIRYGRE--DVTMDEIEKAVKEANAYDFIMKLPHQFDTLVGERGAHVSG 357
Query: 3476 GQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIV 3655
GQKQRIAIARAL+RNPKILLLDEATSALDTESE VQ ALD A + RT IV+AHRLST+
Sbjct: 358 GQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVR 417
Query: 3656 NAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSS 3769
NA I G +VEQG H+EL+ ++G YF L Q++
Sbjct: 418 NADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTA 455
>gi|17508505|ref|NP_491707.1| P-GlycoProtein related (pgp-2)
[Caenorhabditis elegans]
gi|15617726|gb|AAB52482.2| P-glycoprotein related protein 2
[Caenorhabditis elegans]
Length = 1265
Score = 997 bits (2578), Expect = 0.0
Identities = 532/1256 (42%), Positives = 772/1256 (61%), Gaps = 14/1256 (1%)
Frame = +2
Query: 50 FQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGT----IFLDPNST 217
+ ++ YT VD L+L G + + G G PL++I++G ++ F+ + +D +
Sbjct: 36 YGIFYYTQGVDLLLLITGTVAAVIHGAGFPLLAIVLGGMTTVFLRAQNSDFVVGVDNVNP 95
Query: 218 ASEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVM 397
+ EF+ EV++ C+ Y+ LG +F ++Q +CF E+L ++ R+ + +++
Sbjct: 96 EGLVPISLDEFNSEVVKYCIYYLVLGVLMFFTSYVQIACFESYAERLVHKLRQNYLKAIL 155
Query: 398 RQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
RQ+I W+DK +G L+ +L D+LERVREG GDK L QM A F+ G+ V F Y W +TL
Sbjct: 156 RQQIQWFDKQQTGNLTARLTDDLERVREGLGDKFALLVQMFAAFLAGYGVGFFYSWSMTL 215
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
+MM +P +++ G YAVAG IAEE +SIRTV + NG + E R
Sbjct: 216 VMMGFAPLIVLSGAKMSKSMATRTRVEQETYAVAGAIAEETFSSIRTVHSLNGHKRELDR 275
Query: 758 YEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSG-RLESGTVLTVF 934
+ +ALE G++TGI K +G G+ + +Y+SY LAFW G+ + + + G + TVF
Sbjct: 276 FYNALEVGRQTGIVKYCYMGIGVGFSNLCMYSSYALAFWYGSTLIINDPTFDRGLIFTVF 335
Query: 935 FSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVN 1114
F+V+ GS +LG A A+ GTA GAA+++ VI+ P+ID YS EG + G IS
Sbjct: 336 FAVLSGSTSLGGALPHLASFGTARGAASTVLRVINSHPKIDPYSLEGILVDNMKGDISFK 395
Query: 1115 KVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDD 1294
V F YP+R D+ +LKG+SL+ + G +ALVGSSGCGKSTI+ LLQRFY+P G++LID
Sbjct: 396 DVHFRYPSRKDIHVLKGISLELKAGDKIALVGSSGCGKSTIVNLLQRFYDPTKGRVLIDG 455
Query: 1295 IPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKT 1474
+ + + N+ LR+ +G+VSQEP LF+ +I +NI+ G + + + A K ANA DFIK
Sbjct: 456 VDLREVNVHSLREQIGIVSQEPVLFDGTIYENIKMGNEHATHDQVVEACKMANANDFIKR 515
Query: 1475 FPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALEN 1654
P+G T VG++GVQ+SGGQKQRIAIARALV+NPKILLLDEATSALD E+E VQ AL+
Sbjct: 516 LPDGYGTRVGEKGVQLSGGQKQRIAIARALVKNPKILLLDEATSALDTEAEREVQGALDQ 575
Query: 1655 ASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVD 1834
A GRTTI++AHRLST+RN D+I V KAG ++E G+HE L+ ++G+++++ AQV
Sbjct: 576 AQAGRTTIIVAHRLSTIRNVDRIFVFKAGNIVESGSHEELMSKQGIFYDMTQAQVVRQQQ 635
Query: 1835 DKPKK-------KEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXX 1993
+ K + A +SR++S R +++ T Q+
Sbjct: 636 QEAGKDIEDTISESAHSHLSRKSSTRS-AISIATSIHQL--------------------A 674
Query: 1994 XXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDR 2173
A ++FKI ++ + + I G+V P F+L +++I NV+S P
Sbjct: 675 EEVEECKAPPTSMFKIFKFNGDKVGWFIGGIFGAFIFGSVTPVFALVYAEIFNVYSLP-A 733
Query: 2174 DQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFD 2353
DQM+ + +FW MF+++ + G E LTM++R + ++N+LRQD ++D
Sbjct: 734 DQMQANVYFWCGMFVLMGITFFVGFFTSANCLGRCGESLTMKLRFEAFKNLLRQDIAFYD 793
Query: 2354 MPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIF 2533
+H G++ TR ATDAPN++ RL + +I ++ G LGI FYYGWQ+A +++ +
Sbjct: 794 DLRHGTGKLCTRFATDAPNVRYVFT-RLPVVLASIVTICGALGIGFYYGWQLALILVVMV 852
Query: 2534 PFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLD 2713
P + +G M+ G D + +E AGK A +A+E+IRTV +L Q + + +C +L
Sbjct: 853 PLLVMGGYFEMQMRFGKQIRDTQLLEEAGKVASQAVEHIRTVHSLNRQEQFHFTYCEYLR 912
Query: 2714 APHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISF 2893
P N+ A G + F+ S+ FF YAAAF G IF M+P +V RV FAISF
Sbjct: 913 EPFNTNLKHAHTYGAVFAFSQSLIFFMYAAAFYLGS--IFVNQQAMQPIDVYRVFFAISF 970
Query: 2894 SFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVFFRY 3073
IG S+ P+ +KA AA L+F ++E ID ++ SG ++G + + VFF Y
Sbjct: 971 CGQMIGNTTSFIPDVVKARLAASLLFYLIEHPTPIDSLSDSGIVKPITGNISIRNVFFNY 1030
Query: 3074 PERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQM 3253
P R +LQG + +K G+T+ALVG SGCGKST++ LLER Y+ +G + +D +++R +
Sbjct: 1031 PTRKDTKVLQGFTLDIKAGKTVALVGHSGCGKSTIMGLLERFYNQDKGMIMIDGDNIRNL 1090
Query: 3254 NPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDG 3433
N LR+ + +VSQEP LFD +I ENI YG T+++I A ANIH FI LPDG
Sbjct: 1091 NISSLREQVCIVSQEPTLFDCTIGENICYGTNRN-VTYQEIVEAAKMANIHNFILGLPDG 1149
Query: 3434 YETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKD 3613
Y+T VGEKGTQLSGGQKQRIAIARAL+R+P +LLLDEATSALDTESEK VQ ALDAA +
Sbjct: 1150 YDTHVGEKGTQLSGGQKQRIAIARALVRSPSVLLLDEATSALDTESEKIVQEALDAAKQG 1209
Query: 3614 RTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAY--FALTQKQSSNQ 3775
RTC+V+AHRLSTI N+ I +V G++VE+GTH+ELI K Y F TQ+ +Q
Sbjct: 1210 RTCLVIAHRLSTIQNSDVIAIVSEGKIVEKGTHDELIRKSEIYQKFCETQRIVESQ 1265
Score = 375 bits (963), Expect = e-102
Identities = 212/556 (38%), Positives = 309/556 (55%), Gaps = 3/556 (0%)
Frame = +2
Query: 2174 DQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFD 2353
D+ + + + +LVL + + Q + F AERL ++R + +LRQ +FD
Sbjct: 104 DEFNSEVVKYCIYYLVLGVLMFFTSYVQIACFESYAERLVHKLRQNYLKAILRQQIQWFD 163
Query: 2354 MPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIF 2533
K G +T RL D ++ + + + A+ G G+ F+Y W M ++M
Sbjct: 164 --KQQTGNLTARLTDDLERVREGLGDKFALLVQMFAAFLAGYGVGFFYSWSMTLVMMGFA 221
Query: 2534 PFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLD 2713
P + + A M K + + AG A E +IRTV +L + + F + L+
Sbjct: 222 PLIVLSGAKMSKSMATRTRVEQETYAVAGAIAEETFSSIRTVHSLNGHKRELDRFYNALE 281
Query: 2714 APHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISF 2893
I K G+ GF+N + +YA AF +G LI + + + + V FA+
Sbjct: 282 VGRQTGIVKYCYMGIGVGFSNLCMYSSYALAFWYGSTLIIN-DPTFDRGLIFTVFFAVLS 340
Query: 2894 SFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTY-PQLSGEVKLNKVFFR 3070
++G A + + A AA + ++ P+ID + G + G++ V FR
Sbjct: 341 GSTSLGGALPHLASFGTARGAASTVLRVINSHPKIDPYSLEGILVDNMKGDISFKDVHFR 400
Query: 3071 YPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQ 3250
YP R + +L+G+++ +K G +ALVG SGCGKST+++LL+R YDP +G V +D DLR+
Sbjct: 401 YPSRKDIHVLKGISLELKAGDKIALVGSSGCGKSTIVNLLQRFYDPTKGRVLIDGVDLRE 460
Query: 3251 MNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPD 3430
+N LR+ I +VSQEP+LFD +I ENI G + TH+Q+ AC AN + FI LPD
Sbjct: 461 VNVHSLREQIGIVSQEPVLFDGTIYENIKMGNEHA--THDQVVEACKMANANDFIKRLPD 518
Query: 3431 GYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAK 3610
GY TRVGEKG QLSGGQKQRIAIARAL++NPKILLLDEATSALDTE+E++VQ ALD A
Sbjct: 519 GYGTRVGEKGVQLSGGQKQRIAIARALVKNPKILLLDEATSALDTEAEREVQGALDQAQA 578
Query: 3611 DRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQ--SSNQSGG 3784
RT I+VAHRLSTI N I V K G +VE G+H EL++K+G ++ +TQ Q Q
Sbjct: 579 GRTTIIVAHRLSTIRNVDRIFVFKAGNIVESGSHEELMSKQGIFYDMTQAQVVRQQQQEA 638
Query: 3785 AFDTSEALXXXXXXHV 3832
D + + H+
Sbjct: 639 GKDIEDTISESAHSHL 654
>gi|7511698|pir||T31073 multidrug resistance p-glycoprotein - nematode
(Haemonchus contortus)
gi|3057042|gb|AAC38987.1| P-glycoprotein [Haemonchus contortus]
Length = 1275
Score = 988 bits (2555), Expect = 0.0
Identities = 527/1239 (42%), Positives = 756/1239 (60%), Gaps = 8/1239 (0%)
Frame = +2
Query: 71 STVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFV-------TLGTIFLDPNSTASEK 229
+T+D ++LA G + C G G ++ I++G ++ F+ LGT+ DP
Sbjct: 44 TTLDYVLLAAGTLAPCVHGAGFSVLGIVLGGMTTVFLRAQNSEFVLGTVSRDPEGLP--- 100
Query: 230 AAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEI 409
A + EF V + CL Y+ LG +FA ++Q C+ E+++++ R+ + +++RQ+I
Sbjct: 101 ALTKEEFDTLVRRYCLYYLGLGFAMFATSYIQIVCWETFAERITHKLRKIYLKAILRQQI 160
Query: 410 AWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMS 589
+W+D +G L+ +L D+LERVREG GDK+ L QM++ F+ GF V F Y W +TL+MM
Sbjct: 161 SWFDIQQTGNLTARLTDDLERVREGLGDKLSLFIQMVSAFVAGFCVGFAYSWSMTLVMMV 220
Query: 590 LSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDA 769
++PF++I + YAVAG IAEE +SIRTV + G + E R+E A
Sbjct: 221 VAPFIVISANWMSKIVATRTQVEQETYAVAGAIAEETFSSIRTVHSICGHKRELTRFEAA 280
Query: 770 LEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSG-RLESGTVLTVFFSVM 946
LE G++TG+ K F +G G+ + Y SY LAFW G+ + + L+ G + TVFF+VM
Sbjct: 281 LEKGRQTGLVKYFYMGVGVGFGQMCTYVSYALAFWYGSVLIINDPALDRGRIFTVFFAVM 340
Query: 947 MGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEF 1126
GS ALG TI A GA S+ VI+ P+ID YS +G + + G I V F
Sbjct: 341 SGSAALGTCLPHLNTISIARGAVRSVLSVINSRPKIDPYSLDGIVLNNMRGSIRFKNVHF 400
Query: 1127 TYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIE 1306
+YP+R ++ILKGVSL GQ +ALVGSSGCGKST + LL RFY+P G++ IDDI +
Sbjct: 401 SYPSRRTLQILKGVSLQVSAGQKIALVGSSGCGKSTNVNLLLRFYDPTRGKVTIDDIDVC 460
Query: 1307 DFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEG 1486
D N++ LR+ +GVVSQEP LF+ ++ +NI+ G + E++ A + ANAADF K PEG
Sbjct: 461 DLNVQKLREQIGVVSQEPVLFDGTLFENIKMGYEQATMEEVQEACRVANAADFTKRLPEG 520
Query: 1487 LNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRG 1666
T VG+RGVQ+SGGQKQRIAIARA+++NP+ILLLDEATSALD E+ESIVQ ALE A +G
Sbjct: 521 YGTRVGERGVQLSGGQKQRIAIARAIIKNPRILLLDEATSALDTEAESIVQEALEKAQKG 580
Query: 1667 RTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVDDKPK 1846
RTT+++AHRLST+RN D+I V K G ++E GTH L+ ++G++ E+ AQV +
Sbjct: 581 RTTVIVAHRLSTIRNVDQIFVFKNGTIVEQGTHAELMNKRGVFFEMTQAQVLR------Q 634
Query: 1847 KKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXGAVKA 2026
+KE E S S S + A
Sbjct: 635 EKEEEVLDSDAESDVVSPDIALPHLSSLRSRKESTRSAISAVPSVRSMQIEMEDLRAKPT 694
Query: 2027 NLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHFWA 2206
+ KI + R +W Y +I G V P F++ ++QII V+S P DQMK FW
Sbjct: 695 PMSKIFYFNRDKWGYFILGLIACIITGTVTPTFAVLYAQIIQVYSEP-VDQMKGHVLFWC 753
Query: 2207 LMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITT 2386
F+V+ V + F G E LT ++R + ++N+LRQ+ ++D +H G++ T
Sbjct: 754 GAFIVIGLVHAFAFFFSAICLGRCGEALTKKLRFEAFKNLLRQNVGFYDDIRHGTGKLCT 813
Query: 2387 RLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMM 2566
R ATDAPN++ RL + +++ ++ G L I F +GWQ+A ++M + P + M
Sbjct: 814 RFATDAPNVRYVFT-RLPGVLSSVVTIIGALVIGFIFGWQLALILMVMVPLIIGSGYFEM 872
Query: 2567 KYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAI 2746
+ G D + +E AGK A +A+ENIRTV AL Q + + ++C +L P+ N+ +A
Sbjct: 873 RMQFGKKMRDTELLEEAGKVASQAVENIRTVHALNRQEQFHFMYCEYLKEPYRENLCQAH 932
Query: 2747 IRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASY 2926
G + F+ S+ FF YA AF G IF N M+P +V RV FA F +G +S+
Sbjct: 933 TYGGVFAFSQSLLFFMYAVAFWIG--AIFVDNHSMQPIDVYRVFFAFMFCGQMVGNISSF 990
Query: 2927 FPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVFFRYPERPAVPILQG 3106
P+ +KA AA L+F ++E ID ++ G ++SG + V+F YP R + +L+G
Sbjct: 991 IPDVVKARLAASLLFYLIEHPSEIDNLSEDGVTKKISGHISFRNVYFNYPTRRQIRVLRG 1050
Query: 3107 LNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIAL 3286
LN+ + PG T+ALVG SGCGKSTV++LLER Y+ +G +TVD ++R MN ++LR+ + +
Sbjct: 1051 LNLEINPGTTVALVGQSGCGKSTVMALLERFYNQNKGVITVDGENIRNMNIRNLREQVCI 1110
Query: 3287 VSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQ 3466
VSQEP LFD +I ENI YGL + ++EQ+ A ANIH F+ LP+GY+TRVGEKGTQ
Sbjct: 1111 VSQEPTLFDCTIMENICYGLDDPKPSYEQVVAAAKMANIHNFVLGLPEGYDTRVGEKGTQ 1170
Query: 3467 LSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLS 3646
LSGGQKQRIAIARALIR+P ILLLDEATSALDTESEK VQ AL+ A + RTC+V+AHRLS
Sbjct: 1171 LSGGQKQRIAIARALIRDPPILLLDEATSALDTESEKIVQDALEVARQGRTCLVIAHRLS 1230
Query: 3647 TIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQ 3763
TI ++ I++++ G+ ++GTH L+ K Y L + Q
Sbjct: 1231 TIQDSDVIVMIQEGKATDRGTHEHLLMKNDLYKRLCETQ 1269
Score = 348 bits (894), Expect = 4e-94
Identities = 200/526 (38%), Positives = 291/526 (55%), Gaps = 1/526 (0%)
Frame = +2
Query: 2201 WALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRI 2380
+ L +L L + Q + AER+T ++R + +LRQ ++FD+ + G +
Sbjct: 114 YCLYYLGLGFAMFATSYIQIVCWETFAERITHKLRKIYLKAILRQQISWFDIQQ--TGNL 171
Query: 2381 TTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQAL 2560
T RL D ++ + +L +++ G + F Y W M ++M + PF+ +
Sbjct: 172 TARLTDDLERVREGLGDKLSLFIQMVSAFVAGFCVGFAYSWSMTLVMMVVAPFIVISANW 231
Query: 2561 MMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISK 2740
M K + + AG A E +IRTV ++ + F + L+ + K
Sbjct: 232 MSKIVATRTQVEQETYAVAGAIAEETFSSIRTVHSICGHKRELTRFEAALEKGRQTGLVK 291
Query: 2741 AIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAA 2920
G+ GF + +YA AF +G LI + L + + V FA+ +G
Sbjct: 292 YFYMGVGVGFGQMCTYVSYALAFWYGSVLIINDPAL-DRGRIFTVFFAVMSGSAALGTCL 350
Query: 2921 SYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSG-TYPQLSGEVKLNKVFFRYPERPAVPI 3097
+ A A + +++ P+ID + G + G ++ V F YP R + I
Sbjct: 351 PHLNTISIARGAVRSVLSVINSRPKIDPYSLDGIVLNNMRGSIRFKNVHFSYPSRRTLQI 410
Query: 3098 LQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKH 3277
L+G+++ V GQ +ALVG SGCGKST ++LL R YDP G VT+D+ D+ +N + LR+
Sbjct: 411 LKGVSLQVSAGQKIALVGSSGCGKSTNVNLLLRFYDPTRGKVTIDDIDVCDLNVQKLREQ 470
Query: 3278 IALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEK 3457
I +VSQEP+LFD ++ ENI G + + T E+++ AC AN F LP+GY TRVGE+
Sbjct: 471 IGVVSQEPVLFDGTLFENIKMGYE--QATMEEVQEACRVANAADFTKRLPEGYGTRVGER 528
Query: 3458 GTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAH 3637
G QLSGGQKQRIAIARA+I+NP+ILLLDEATSALDTE+E VQ AL+ A K RT ++VAH
Sbjct: 529 GVQLSGGQKQRIAIARAIIKNPRILLLDEATSALDTEAESIVQEALEKAQKGRTTVIVAH 588
Query: 3638 RLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSSNQ 3775
RLSTI N I V KNG +VEQGTH EL+ KRG +F +TQ Q Q
Sbjct: 589 RLSTIRNVDQIFVFKNGTIVEQGTHAELMNKRGVFFEMTQAQVLRQ 634
>gi|9961252|ref|NP_061338.1| ATP-binding cassette, subfamily B, member
4 isoform C; P glycoprotein 3/multiple drug resistance 3;
P-glycoprotein-3/multiple drug resistance-3; multiple
drug resistance 3 [Homo sapiens]
Length = 1232
Score = 984 bits (2545), Expect = 0.0
Identities = 551/1261 (43%), Positives = 761/1261 (59%), Gaps = 15/1261 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
I + L+RY+ D+L +++G I++ A G GLPLM I+ G ++ FV F P + +
Sbjct: 40 IGVLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFS 99
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
E+ + Y LG G+ A ++Q S + + + + R++FFH+++R
Sbjct: 100 LSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILR 159
Query: 401 QEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLI 580
QEI W+D N + L+ +L D++ ++ EG GDKVG+ FQ +A F GF V F W LTL+
Sbjct: 160 QEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLV 219
Query: 581 MMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRY 760
+M++SP + + YA AG +AEE L +IRTVIAF GQ E +RY
Sbjct: 220 IMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERY 279
Query: 761 EDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFS 940
+ LE+ K+ GIKK+ + F++IYASY LAFW G+ V S G +TVFFS
Sbjct: 280 QKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFS 339
Query: 941 VMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKV 1120
+++G+ ++GQA A GAA ++++ID P+ID++S G P I G + N V
Sbjct: 340 ILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDV 399
Query: 1121 EFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIP 1300
F+YP+RA+VKILKG++L Q GQTVALVGSSGCGKST +QL+QR Y+PD G I ID
Sbjct: 400 HFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQD 459
Query: 1301 IEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFP 1480
I +FN+ YLR+++GVVSQEP LF+T+I +NI YGR +V+ ++I +A+KEANA +FI P
Sbjct: 460 IRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLP 519
Query: 1481 EGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENAS 1660
+ +TLVG+RG Q+SGGQKQRIAIARALVRNPKILLLDEATSALD ESE+ VQ+AL+ A
Sbjct: 520 QKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAR 579
Query: 1661 RGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQV------- 1819
GRTTIVIAHRLSTVRNAD I + G ++E G+H L++++G+Y +LV+ Q
Sbjct: 580 EGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQS 639
Query: 1820 --FADVDDKPKKKEA----ERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXX 1981
F D+K + A + R+ R ++Q K N + + +D
Sbjct: 640 EEFELNDEKAATRMAPNGWKSRLFRHSTQ-KNLKNSQMCQKSLD---------------- 682
Query: 1982 XXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFS 2161
+ K+L+ + EW Y + G + PAFS+ FS+II +F
Sbjct: 683 --VETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFG 740
Query: 2162 NPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDA 2341
D ++ + ++L+FL L + + Q FG A E LT R+RS ++ +LRQD
Sbjct: 741 PGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDM 800
Query: 2342 TYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLV 2521
++FD K+S G ++TRLATDA ++ A RL I IA++G G+ I+F YGWQ+ L+
Sbjct: 801 SWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLL 860
Query: 2522 MAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFC 2701
+A+ P +AV + MK G+A D KE+E AGK A EAIENIRTV +LT + K +++
Sbjct: 861 LAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYV 920
Query: 2702 SHLDAPHGGNISKAIIRG-LTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVL 2878
L P+ + AI+ G + G A+S
Sbjct: 921 EKLYGPY--RVFSAIVFGAVALGHASS--------------------------------- 945
Query: 2879 FAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYP-QLSGEVKLN 3055
FA Y KA +A +F + E +P ID + G P + G + N
Sbjct: 946 -----------FAPDY----AKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFN 990
Query: 3056 KVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDN 3235
+V F YP R VP+LQGL++ VK GQTLALVG SGCGKSTV+ LLER YDPL G V +D
Sbjct: 991 EVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDG 1050
Query: 3236 NDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFI 3415
+ +++N + LR + +VSQEPILFD SI ENI YG + ++I +A ANIH FI
Sbjct: 1051 QEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFI 1110
Query: 3416 DELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVAL 3595
+ LP YETRVG+KGTQLSGGQKQRIAIARALIR P+ILLLDEATSALDTESEK VQ AL
Sbjct: 1111 ETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEAL 1170
Query: 3596 DAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSSNQ 3775
D A + RTCIV+AHRLSTI NA I+V +NG+V E GTH +L+A++G YF++ Q+ Q
Sbjct: 1171 DKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQ 1230
Query: 3776 S 3778
+
Sbjct: 1231 N 1231
>gi|6472653|dbj|BAA87071.1| multi-drug resistance related mRNA [Felis
catus]
Length = 1163
Score = 980 bits (2534), Expect = 0.0
Identities = 527/1182 (44%), Positives = 735/1182 (61%), Gaps = 22/1182 (1%)
Frame = +2
Query: 125 GVGLPLMSIIMGNVSQNFVTLG-TIFLDPNSTASEKAAARAEFSHEVIQNCLKYVY---- 289
G LPLM ++ G+++ +F G + L + E + F + + + Y Y
Sbjct: 2 GAALPLMMLVFGDMTDSFANAGISRNLTTLNITGESIVNDSYFINRLEEEMTTYAYYYSG 61
Query: 290 LGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYDKNTSGTLSNKLFDNLE 469
+G G+ A ++Q S + + + + R+QFFH++MRQE+ W+D + G L+ +L D++
Sbjct: 62 IGAGVLVAAYIQVSFWCLAAGRQILKIRKQFFHAIMRQEVGWFDVHDVGELNTRLTDDVS 121
Query: 470 RVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXXXXXXXXX 649
++ EG GDK+G+ FQ MA F GF V FT W LTL+++++SP + +
Sbjct: 122 KINEGIGDKIGMFFQSMATFFIGFIVGFTRGWKLTLVILAISPVLGLSAAIWAKILSSFT 181
Query: 650 XXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFLIGAGLA 829
YA AG +AEEVL +IRTVIAF GQ+ E +RY LE K+ GIKK+ +
Sbjct: 182 DKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIG 241
Query: 830 SFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQFATIGTALG 1009
F++IYASY LAFW GT+ V S G VLTVFFSV++G+ ++GQA A G
Sbjct: 242 IAFLLIYASYALAFWYGTSLVLSHEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARG 301
Query: 1010 AAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKGVSLDAQPG 1189
AA ++++ID P ID+YS G P I G + V F+YP+R +VKILKG++L Q G
Sbjct: 302 AAYEIFKIIDNKPSIDSYSKNGHKPDNIKGNLEFKNVHFSYPSRKEVKILKGLNLKVQSG 361
Query: 1190 QTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLF 1369
QTVALVG+SGCGKST +QL+QR Y+P G + ID I N++YLR+++GVVSQEP LF
Sbjct: 362 QTVALVGNSGCGKSTTVQLMQRLYDPTDGMVSIDGQDIRTINVRYLREIIGVVSQEPVLF 421
Query: 1370 NTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIA 1549
T+I +NIRYGR +V+ E+I +A+KEANA DFI P +TLVG+RG Q+SGGQKQRIA
Sbjct: 422 ATTIAENIRYGRENVTMEEIEKAVKEANAYDFIMKLPNKFDTLVGERGAQLSGGQKQRIA 481
Query: 1550 IARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLSTVRNADKIIV 1729
IARALVRNPKILLLDEATSALD+ESE++VQ AL+ A +GRTTIV+AHRLST+RNAD I
Sbjct: 482 IARALVRNPKILLLDEATSALDSESEAVVQVALDKARKGRTTIVVAHRLSTIRNADVIAG 541
Query: 1730 MKAGQVMEVGTHETLIEQKGLYHELVHAQ-----------VFADVDD----KPKKKEAER 1864
G ++E G H+ L++++G+Y +LV Q V+ + + + K++
Sbjct: 542 FDDGVIVEKGNHDELMKEEGIYFKLVTMQTRGNEIELENAVYESISEIDALEMSPKDSGS 601
Query: 1865 RMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXGAVKANLFKIL 2044
+ R+ S RK + Q+ ++ + ++IL
Sbjct: 602 SLIRRRSTRKSIHASQGQDRKLGTKENLDER-------------------VPPVSFWRIL 642
Query: 2045 RYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSN-PDRDQMKKDGHFWALMFLV 2221
+ EW Y +I G + PAFS+ S+II VF+ D + +++ + ++L+FLV
Sbjct: 643 KLNITEWPYFVVGIFCAIINGGLQPAFSVILSRIIGVFTRVEDPETKRQNSNIFSLLFLV 702
Query: 2222 LAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATD 2401
L + + Q FG A E LT R+R V+R++LRQD ++FD PK++ G +TTRLA D
Sbjct: 703 LGIISSITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLAND 762
Query: 2402 APNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGG 2581
A +K AI RL I IA++G G+ I+ YGWQ+ L++AI P +A+ + MK G
Sbjct: 763 AAQVKGAIGSRLAIITQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSG 822
Query: 2582 SATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLT 2761
A D KE+E AGK A EAIEN RTV +LT + K ++ L P+ ++ KA I G++
Sbjct: 823 QALKDKKELEGAGKVATEAIENFRTVVSLTREQKFEYMYAQSLQVPYRNSLRKAHIFGIS 882
Query: 2762 YGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYI 2941
+ ++ +F+YA FRFG +L+ + M+ ++VL V AI F +G +S+ P+Y
Sbjct: 883 FSITQAMMYFSYAGCFRFGAYLV--AHEFMDFQDVLLVFSAIVFGAMAVGQVSSFAPDYA 940
Query: 2942 KATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKLNKVFFRYPERPAVPILQGLNVH 3118
KA +A + ++E+ P ID ++ G P L G V N+V F YP RP +P+LQGL++
Sbjct: 941 KAKVSAAHVIMIIEKIPLIDSYSTEGLMPNTLEGNVTFNEVMFNYPTRPDIPVLQGLSLE 1000
Query: 3119 VKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQE 3298
VK GQTLALVG SGCGKSTV+ LLER YDP+ G V +D +++ +N + LR H+ +VSQE
Sbjct: 1001 VKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVLIDGKEIKHLNVQWLRAHMGIVSQE 1060
Query: 3299 PILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGG 3478
PILFD SI ENI YG + E+I A +ANIH FI+ LPD Y TRVG+KGTQLSGG
Sbjct: 1061 PILFDCSIGENIAYGDNSRVVSQEEIVRAAKEANIHPFIETLPDKYNTRVGDKGTQLSGG 1120
Query: 3479 QKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAA 3604
QKQRIAIARAL+R P+ILLLDEATSALDTESEK VQ ALD A
Sbjct: 1121 QKQRIAIARALVRQPRILLLDEATSALDTESEKVVQEALDKA 1162
Score = 373 bits (957), Expect = e-101
Identities = 224/576 (38%), Positives = 325/576 (55%), Gaps = 22/576 (3%)
Frame = +2
Query: 2105 GAVMPAFSLFFSQIINVFSNPD-----------RDQMKKDGHF----------WALMFLV 2221
GA +P L F + + F+N + + D +F +A +
Sbjct: 2 GAALPLMMLVFGDMTDSFANAGISRNLTTLNITGESIVNDSYFINRLEEEMTTYAYYYSG 61
Query: 2222 LAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATD 2401
+ A + Q S + +AA R ++IR + + ++RQ+ +FD+ H G + TRL D
Sbjct: 62 IGAGVLVAAYIQVSFWCLAAGRQILKIRKQFFHAIMRQEVGWFDV--HDVGELNTRLTDD 119
Query: 2402 APNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGG 2581
I I ++G F ++A+ G + F GW++ +++AI P + + A+ K
Sbjct: 120 VSKINEGIGDKIGMFFQSMATFFIGFIVGFTRGWKLTLVILAISPVLGLSAAIWAKILSS 179
Query: 2582 SATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLT 2761
+ AG A E + IRTV A Q K + +L+ I KAI ++
Sbjct: 180 FTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANIS 239
Query: 2762 YGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYI 2941
G A + + +YA AF +G L+ + VL V F++ ++G A+ +
Sbjct: 240 IGIAFLLIYASYALAFWYGTSLVLSHEYSIG--QVLTVFFSVLIGAFSVGQASPSIEAFA 297
Query: 2942 KATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKLNKVFFRYPERPAVPILQGLNVH 3118
A AA IF +++ +P ID + +G P + G ++ V F YP R V IL+GLN+
Sbjct: 298 NARGAAYEIFKIIDNKPSIDSYSKNGHKPDNIKGNLEFKNVHFSYPSRKEVKILKGLNLK 357
Query: 3119 VKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQE 3298
V+ GQT+ALVG SGCGKST + L++RLYDP +G V++D D+R +N ++LR+ I +VSQE
Sbjct: 358 VQSGQTVALVGNSGCGKSTTVQLMQRLYDPTDGMVSIDGQDIRTINVRYLREIIGVVSQE 417
Query: 3299 PILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGG 3478
P+LF T+I ENI YG + T E+IE A +AN + FI +LP+ ++T VGE+G QLSGG
Sbjct: 418 PVLFATTIAENIRYGRE--NVTMEEIEKAVKEANAYDFIMKLPNKFDTLVGERGAQLSGG 475
Query: 3479 QKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVN 3658
QKQRIAIARAL+RNPKILLLDEATSALD+ESE VQVALD A K RT IVVAHRLSTI N
Sbjct: 476 QKQRIAIARALVRNPKILLLDEATSALDSESEAVVQVALDKARKGRTTIVVAHRLSTIRN 535
Query: 3659 AGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQS 3766
A I +G +VE+G H+EL+ + G YF L Q+
Sbjct: 536 ADVIAGFDDGVIVEKGNHDELMKEEGIYFKLVTMQT 571
Score = 354 bits (908), Expect = 1e-95
Identities = 203/526 (38%), Positives = 305/526 (57%), Gaps = 6/526 (1%)
Frame = +2
Query: 98 VGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHEVIQNCL 277
VGI + G P S+I+ + F + DP + N
Sbjct: 654 VGIFCAIINGGLQPAFSVILSRIIGVFTRVE----DPETKRQNS-------------NIF 696
Query: 278 KYVYLGCGIFAA--GFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYD--KNTSGTLS 445
++L GI ++ FLQ F E L+ R R F S++RQ+++W+D KNT+G L+
Sbjct: 697 SLLFLVLGIISSITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALT 756
Query: 446 NKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFX 625
+L ++ +V+ G ++ + Q +A G ++ Y W LTL+++++ P + I G+
Sbjct: 757 TRLANDAAQVKGAIGSRLAIITQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVE 816
Query: 626 XXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKS 805
+ AG +A E + + RTV++ ++ Y +L+ + ++K+
Sbjct: 817 MKMLSGQALKDKKELEGAGKVATEAIENFRTVVSLTREQKFEYMYAQSLQVPYRNSLRKA 876
Query: 806 FLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQF 985
+ G + ++Y SY F G V ++ VL VF +++ G+MA+GQ
Sbjct: 877 HIFGISFSITQAMMYFSYAGCFRFGAYLVAHEFMDFQDVLLVFSAIVFGAMAVGQVSSFA 936
Query: 986 ATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKG 1165
A +AA + +I++IP ID+YSTEG P+ + G ++ N+V F YPTR D+ +L+G
Sbjct: 937 PDYAKAKVSAAHVIMIIEKIPLIDSYSTEGLMPNTLEGNVTFNEVMFNYPTRPDIPVLQG 996
Query: 1166 VSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGV 1345
+SL+ + GQT+ALVGSSGCGKST++QLL+RFY+P AG +LID I+ N+++LR +G+
Sbjct: 997 LSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVLIDGKEIKHLNVQWLRAHMGI 1056
Query: 1346 VSQEPNLFNTSIEQNIRYGRSD--VSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQ 1519
VSQEP LF+ SI +NI YG + VS E+I RA KEAN FI+T P+ NT VGD+G Q
Sbjct: 1057 VSQEPILFDCSIGENIAYGDNSRVVSQEEIVRAAKEANIHPFIETLPDKYNTRVGDKGTQ 1116
Query: 1520 MSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENA 1657
+SGGQKQRIAIARALVR P+ILLLDEATSALD ESE +VQ AL+ A
Sbjct: 1117 LSGGQKQRIAIARALVRQPRILLLDEATSALDTESEKVVQEALDKA 1162
>gi|17569143|ref|NP_509901.1| P-GlycoProtein related (pgp-3)
[Caenorhabditis elegans]
gi|29429184|sp|P34713|MDR3_CAEEL Multidrug resistance protein 3
(P-glycoprotein C)
gi|7511155|pir||T22094 hypothetical protein ZK455.7 - Caenorhabditis
elegans
gi|3877009|emb|CAA91467.1| Hypothetical protein ZK455.7
[Caenorhabditis elegans]
gi|3881645|emb|CAA91495.1| C. elegans PGP-3 protein (corresponding
sequence ZK455.7) [Caenorhabditis elegans]
Length = 1268
Score = 962 bits (2487), Expect = 0.0
Identities = 519/1251 (41%), Positives = 750/1251 (59%), Gaps = 9/1251 (0%)
Frame = +2
Query: 44 SIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTAS 223
+ F ++R D ++ + G+I+S G +P S+I F + ++ S
Sbjct: 30 NFFDVFRDADYKDYILFSGGLILSAVNGALVPFNSLI-------FEGIANALMEGESQYQ 82
Query: 224 EKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQ 403
FS E+ CL+Y YLG +F + SC +CE+ + R+++ SV+RQ
Sbjct: 83 NGTINMPWFSSEIKMFCLRYFYLGVALFLCSYFANSCLYTLCERRLHCIRKKYLKSVLRQ 142
Query: 404 EIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIM 583
+ W+D+ T G L+ K+ +E++++G GDKVG+ +A FI G ++ F W LTL+M
Sbjct: 143 DAKWFDETTIGGLTQKMSSGIEKIKDGIGDKVGVLVGGVATFISGVSIGFYMCWQLTLVM 202
Query: 584 MSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYE 763
M P + Y+ AGG+A EV+ IRTV+AFN Q +E RY
Sbjct: 203 MITVPLQLGSMYLSAKHLNRATKNEMSAYSNAGGMANEVIAGIRTVMAFNAQPFEINRYA 262
Query: 764 DALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSV 943
L ++ GI+K+ ++ A ++++ +AFW G +G + SG V VF++V
Sbjct: 263 HQLNEARRMGIRKAIILAICTAFPLMLMFTCMAVAFWYGATLAAAGAVSSGAVFAVFWAV 322
Query: 944 MMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVE 1123
++G+ LG+A I A A +++VID PEI S+EG+ P KI G+++ + +E
Sbjct: 323 LIGTRRLGEAAPHLGAITGARLAIHDIFKVIDHEPEIKCTSSEGKIPEKIQGKLTFDGIE 382
Query: 1124 FTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPI 1303
FTYPTR ++KILKGVS + PG+TVALVG SGCGKST I LL RFYN AG I +D IPI
Sbjct: 383 FTYPTRPELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPI 442
Query: 1304 EDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPE 1483
+++NI++LR +G+V QEP +F ++ +NIR G ++D+DI A K ANA +FI +
Sbjct: 443 QEYNIRWLRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSD 502
Query: 1484 GLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASR 1663
+T++G VQ+SGGQKQR+AIARA+VR P+ILLLDEATSALD ESE +VQ+AL+ AS
Sbjct: 503 RYDTVIGAGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASE 562
Query: 1664 GRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLI-EQKGLYHELVHAQVFADVDDK 1840
GRTT+ IAHRLST+RNA KI+V G + E GTH+ LI + G+Y +V AQ +
Sbjct: 563 GRTTLCIAHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAKED 622
Query: 1841 PKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXX--------XXXX 1996
+ E + ++ R + + +E Q
Sbjct: 623 TTLDDEEDEKTHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPEWEIENARE 682
Query: 1997 XXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRD 2176
GA++A+LF I +YA PE LI+G PAFS+ + Q+ + S D
Sbjct: 683 EMIEEGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILS-AGGD 741
Query: 2177 QMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDM 2356
+ +L F++LA G S L SL G A E ++ R+R V+RN+++QDA+YFD
Sbjct: 742 DVSIKALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDD 801
Query: 2357 PKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFP 2536
+H+ G +T+RLATDAPN+++AID RL + I S+ G+G+AFYYGW MA + +A
Sbjct: 802 SRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGLATAL 861
Query: 2537 FMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDA 2716
+ V Q+ + +Y D A + E+I N +TVQALT Q +Y+ F + +
Sbjct: 862 LLVVVQSSVAQYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKS 921
Query: 2717 PHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFS 2896
PH I + + + L++ A S + +A A+ FGL+LI N P V +V+ A++ +
Sbjct: 922 PHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLI--SNNWSTPYTVFQVIEALNMA 979
Query: 2897 FGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVFFRYP 3076
++ AASYFPEY++A +AG++F M+ ++ ID +G P + G + + V+F YP
Sbjct: 980 SMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFAYP 1039
Query: 3077 ERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMN 3256
R +L G N+ GQT+ALVGPSGCGKST I L+ER YD L G+V +D++D+R ++
Sbjct: 1040 NRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLS 1099
Query: 3257 PKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGY 3436
KHLR +IALV QEP LF+ +IRENI YGL+ T +Q+E A + ANIH F+ LPDGY
Sbjct: 1100 VKHLRDNIALVGQEPTLFNLTIRENITYGLE--NITQDQVEKAATLANIHTFVMGLPDGY 1157
Query: 3437 ETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDR 3616
+T VG G +LSGGQKQR+AIARA++R+PKILLLDEATSALDTESEK VQ ALD A R
Sbjct: 1158 DTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGR 1217
Query: 3617 TCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSS 3769
TC+V+AHRLSTI NA I+V +NG+ +E+GTH L+A+RG Y+ L +KQSS
Sbjct: 1218 TCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS 1268
>gi|39594783|emb|CAE70651.1| Hypothetical protein CBG17356
[Caenorhabditis briggsae]
Length = 1265
Score = 961 bits (2484), Expect = 0.0
Identities = 518/1251 (41%), Positives = 752/1251 (59%), Gaps = 9/1251 (0%)
Frame = +2
Query: 44 SIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTAS 223
S+ L+R++ +D L+L GI+ S A+G LP S+I ++ + + S
Sbjct: 28 SLSNLFRHSDCLDYLLLLGGIVFSSASGALLPFNSLIFEGITN-------VLMQGQSEWQ 80
Query: 224 EKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQ 403
A FS + CL Y LG +F ++ +C + E+ R+ SV+RQ
Sbjct: 81 NGTFAYDTFSTGIRHYCLLYFLLGVFMFLCTYISNACLYTMAERRLYCIRKHLLRSVLRQ 140
Query: 404 EIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIM 583
+ W+D+NT G L+ K+ +E++++G GDK+G+ F A FI G + F W LTL+M
Sbjct: 141 DAQWFDENTVGGLTQKMSSGIEKIKDGIGDKIGVLFSGAATFISGVLLGFYMCWQLTLVM 200
Query: 584 MSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYE 763
+ P + Y+ AGG+A EV+ IRTVIAFN Q +E RY
Sbjct: 201 LITVPLQLGQMYMSAKHLNRATKNEMSAYSSAGGMANEVIAGIRTVIAFNAQPFEISRYA 260
Query: 764 DALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSV 943
D L ++ GI+KS ++ + A V+++ AFW G G SGT VF++V
Sbjct: 261 DKLAEARQMGIRKSIVLASCSAVPLVLMFVLMAGAFWYGAILTSFGIATSGTTFGVFWAV 320
Query: 944 MMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVE 1123
++G+ LG+A I A A +++VID PEI+ G+ P KI+G+++ + +E
Sbjct: 321 LLGTRRLGEAAPHMGAILGARLAINDIFKVIDNEPEINCTKETGRRPEKINGKLNFDNIE 380
Query: 1124 FTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPI 1303
FTYPTR DVKILKGVS + PG+TVALVG SGCGKST I LL RFYN AG I +D +PI
Sbjct: 381 FTYPTRPDVKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGTIKLDGVPI 440
Query: 1304 EDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPE 1483
ED+NI++LR +G+V QEP +F ++ +NIR G + ++D+DI A ++ANA DFI +
Sbjct: 441 EDYNIQWLRSTIGIVQQEPIIFLATVSENIRMGDNSITDKDIEDACRQANAHDFIGHLSD 500
Query: 1484 GLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASR 1663
G NT++G VQ+SGGQKQR+AIARA+VR P+ILLLDEATSALD ESE +VQ+AL+ AS+
Sbjct: 501 GYNTIIGAGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQAALDKASQ 560
Query: 1664 GRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQ--------- 1816
GRTT+ IAHRLST+RNA+KI+V G ++E GTH+ LI Q G+Y +V AQ
Sbjct: 561 GRTTLCIAHRLSTIRNANKILVFDQGLIVEKGTHDQLIRQNGIYASMVRAQEIERAKEDT 620
Query: 1817 VFADVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXX 1996
V D + + + RR+S + + S + +++
Sbjct: 621 VVEDDSLEEETQSISRRLSTSEDEVRKSKSLLRDSARL-SQSMLSVTSQVPDWEVEIARE 679
Query: 1997 XXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRD 2176
GA++A++ I R+A+PE LI+G PAFS+ + Q+ VF+ D
Sbjct: 680 EMFEEGAMEASMMDIFRFAKPEKWNVIIALIVTLIRGITWPAFSVVYGQLFKVFAEGGED 739
Query: 2177 QMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDM 2356
+ + +L F++LA G + SL G E ++ R+R V++N+++QDA+YFD
Sbjct: 740 -LPTNAFVSSLWFILLAFTSGITTFISGSLLGKTGETMSSRLRLNVFKNIMQQDASYFDE 798
Query: 2357 PKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFP 2536
PKH+ G +T RLATD+ N+++AID+RL + N + S+ G+ +AF++GW MA + +
Sbjct: 799 PKHNVGNLTARLATDSQNVQAAIDHRLAEVLNGVISLFAGIAVAFWFGWSMAPIGLLTAL 858
Query: 2537 FMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDA 2716
+ + Q+ + +Y D + A + E+I N +TVQALT Q +Y F +
Sbjct: 859 LLVIAQSSVAQYLKYRGPKDMESAIEASRIVTESISNWKTVQALTKQEYMYGAFTTASKK 918
Query: 2717 PHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFS 2896
P +K + + L++ A S + +A A+ FGL+LI N P V +V+ A++ +
Sbjct: 919 PRQRAFAKGLWQSLSFALAGSFFLWNFAIAYMFGLWLI--SNNWTTPFAVFQVIEALNMA 976
Query: 2897 FGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVFFRYP 3076
++ AASYFPEY++A +AG++F M+ ++ ID +G P + G++ + V+F YP
Sbjct: 977 SMSVMMAASYFPEYVRARISAGIMFTMIRQKSAIDNRGLTGETPLIKGDISMRGVYFAYP 1036
Query: 3077 ERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMN 3256
R IL N+ GQT+ALVGPSGCGKST I L+ER YD + G+V +D+ D+R ++
Sbjct: 1037 NRKRQLILNNFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDAVCGSVRIDDTDVRDIS 1096
Query: 3257 PKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGY 3436
KHLR +IALV QEP LF+ SIRENI YGL+ + EQIE A ANIH F+ LP+GY
Sbjct: 1097 VKHLRDNIALVGQEPTLFNLSIRENITYGLE--NVSQEQIEEAAKLANIHNFVISLPEGY 1154
Query: 3437 ETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDR 3616
+T VG G +LSGGQKQRIAIARA++R+PKILLLDEATSALD+ESEK VQ ALD A R
Sbjct: 1155 DTSVGASGGRLSGGQKQRIAIARAIVRDPKILLLDEATSALDSESEKIVQEALDKARLGR 1214
Query: 3617 TCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSS 3769
TC+V+AHRLSTI NA I+V +NG+ +E+GTH L+A+RG Y+ L +KQS+
Sbjct: 1215 TCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQSLLARRGLYYRLVEKQST 1265
>gi|17569145|ref|NP_509902.1| P-GlycoProtein related (pgp-4)
[Caenorhabditis elegans]
gi|7503247|pir||T22090 hypothetical protein F42E11.1 - Caenorhabditis
elegans
gi|3877005|emb|CAA91463.1| Hypothetical protein F42E11.1
[Caenorhabditis elegans]
Length = 1266
Score = 955 bits (2468), Expect = 0.0
Identities = 511/1252 (40%), Positives = 749/1252 (59%), Gaps = 10/1252 (0%)
Frame = +2
Query: 44 SIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTAS 223
S+ L+R++ D L+L G+++S A G LP S+I ++ + + +
Sbjct: 28 SLSNLFRHSGCADYLLLLGGLVLSAANGALLPFNSLIFEGITN-------VLMKGEAQWQ 80
Query: 224 EKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQ 403
FS + CL Y LG +F + +C + E+ R+ SV+RQ
Sbjct: 81 NGTFDYDTFSSGIQHYCLLYFLLGVLMFTCTYFSNACLFTMAERRLYCIRKHLLQSVLRQ 140
Query: 404 EIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIM 583
+ W+D+NT G L+ K+ +E++++G GDK+G+ +A FI G A+ F W LTL+M
Sbjct: 141 DAKWFDENTVGGLTQKMSSGIEKIKDGIGDKIGVLVSGIATFISGVALGFYMCWQLTLVM 200
Query: 584 MSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYE 763
+ P + Y+ AGG+A EV+ IRTVIAFN Q +E +RY
Sbjct: 201 LVTVPLQLGSMYLSAKHLNRATKNEMSAYSSAGGMANEVIAGIRTVIAFNAQPFEIERYG 260
Query: 764 DALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSV 943
L +K GI+K+ ++ A +++ AFW G G SGT VF++V
Sbjct: 261 AQLAKARKMGIRKAIVLALCSAMPLFLMFVLMAGAFWYGAILTSYGVATSGTTFGVFWAV 320
Query: 944 MMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVE 1123
++G+ LG+A I A A +++VID PEI+ EG+ P K++G++ + ++
Sbjct: 321 ILGTRRLGEAAPHMGAITGARLAVNDIFKVIDHEPEINCTKQEGRRPDKVNGKLVFDNIQ 380
Query: 1124 FTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPI 1303
FTYPTR DVKILKGVS + PG+T+ALVG SGCGKST I LL RFYN AG I +D IPI
Sbjct: 381 FTYPTRPDVKILKGVSFEVNPGETIALVGHSGCGKSTSIGLLMRFYNQCAGSIKLDGIPI 440
Query: 1304 EDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPE 1483
ED+NI++LR +G+V QEP +F ++ +N+R G ++D+DI A ++ANA DFI E
Sbjct: 441 EDYNIQWLRSTIGIVQQEPIIFLATVAENVRMGDDSITDKDIENACRQANAHDFIGKLSE 500
Query: 1484 GLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASR 1663
G NT++G VQ+SGGQKQR+AIARA+VR P+ILLLDEATSALD ESE +VQ+AL+ AS
Sbjct: 501 GYNTVIGAGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASE 560
Query: 1664 GRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVDDKP 1843
GRTT+ IAHRLST+RNA KI+V G + E G H+ LI Q G+Y +V AQ D
Sbjct: 561 GRTTLCIAHRLSTIRNASKILVFDQGLIPERGIHDQLIRQNGIYANMVRAQEIEKAKDDT 620
Query: 1844 KKKEAE----------RRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXX 1993
+ + E RR+S + + S + ++S
Sbjct: 621 TQDDDELVEEDNYSISRRLSTSEEELRKSKSL-LRDSTRFSQSMLSVTSQVPDWEMESAR 679
Query: 1994 XXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDR 2173
GA++A++ I R+A+PE + LI+G PAFS+ + Q+ VF+
Sbjct: 680 EEMIEEGAMEASMMDIFRFAKPEKMNIVIALIFTLIRGITWPAFSVVYGQLFKVFAEGGE 739
Query: 2174 DQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFD 2353
D + + +L F++LA + SL G E ++ R+R V++N+++QDATYFD
Sbjct: 740 D-LPVNALISSLWFVLLAVTSAVTTFISGSLLGKTGETMSSRLRMDVFKNIMQQDATYFD 798
Query: 2354 MPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIF 2533
PKH+ G +T+RLATD+ N+++AID+RL + N + S+ G+ +AF++GW MA + +
Sbjct: 799 DPKHNVGNLTSRLATDSQNVQAAIDHRLAEVLNGVVSLFTGIAVAFWFGWSMAPIGLITA 858
Query: 2534 PFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLD 2713
+ + Q+ + +Y D + A + E+I N +TVQALT Q +++ F +
Sbjct: 859 LLLVIAQSAVAQYLKYRGPKDMESAIEASRIVTESISNWKTVQALTKQEYMFHAFTAASK 918
Query: 2714 APHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISF 2893
P +K + + L++ A S + +A A+ FGL+LI N P V +V+ A++
Sbjct: 919 NPRKRAFTKGLWQSLSFALAGSFFLWNFAIAYMFGLWLI--SNNWTTPFAVFQVIEALNM 976
Query: 2894 SFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVFFRY 3073
+ ++ AASYFPEY++A +AG++F M+ ++ +ID +G P + G++ + V+F Y
Sbjct: 977 ASMSVMMAASYFPEYVRARISAGIMFTMIRQKAKIDNRGLTGETPDIRGDISMKGVYFAY 1036
Query: 3074 PERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQM 3253
P R IL N+ + G+T+ALVGPSGCGKST I L+ER YD + GAV +D++D+R +
Sbjct: 1037 PNRNRQLILNNFNMSAQFGETVALVGPSGCGKSTSIQLIERYYDAICGAVKIDDHDIRDI 1096
Query: 3254 NPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDG 3433
+ KHLR +IALV QEP LF+ +IRENI YGL+ + EQ+E A + ANIH F++ LP+G
Sbjct: 1097 SVKHLRHNIALVGQEPTLFNLTIRENITYGLE--NVSQEQVEKAATLANIHSFVENLPEG 1154
Query: 3434 YETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKD 3613
Y+T VG G +LSGGQKQRIAIARA++RNPKILLLDEATSALDTESEK VQ ALD A
Sbjct: 1155 YDTSVGASGGRLSGGQKQRIAIARAIVRNPKILLLDEATSALDTESEKIVQEALDKARLG 1214
Query: 3614 RTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSS 3769
RTC+V+AHRLSTI NA I+V +NG+ +E+GTH L+A+RG Y+ L +KQS+
Sbjct: 1215 RTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQST 1266
>gi|45361353|ref|NP_989254.1| hypothetical protein MGC76216 [Xenopus
tropicalis]
gi|39645391|gb|AAH63924.1| Hypothetical protein MGC76216 [Xenopus
tropicalis]
Length = 1261
Score = 954 bits (2466), Expect = 0.0
Identities = 529/1258 (42%), Positives = 752/1258 (59%), Gaps = 16/1258 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
ISIFQ + +D ++ +G + + G PLM+++ G +S +F+ ++++
Sbjct: 40 ISIFQ---FADWLDIFLMIIGTLGAIGCGSCYPLMNVVFGEMSDSFLC--------HNSS 88
Query: 221 SEKAAARAEFS---HEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHS 391
+ ++A A+F E+ + L Y LG + G+LQ SC++V + + + R+ FFHS
Sbjct: 89 LQNSSACAKFKPIEEEIQKFSLYYAGLGFAVLFCGYLQVSCWVVAASRQTRKMRKAFFHS 148
Query: 392 VMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLL 571
V+ QEI W+D SG L+ +L +N+ ++ +G GDKV FQ + G + W L
Sbjct: 149 VLSQEIGWFDVTKSGDLNTRLTENINKINDGIGDKVAHFFQNTTICVSGILIGLIQGWKL 208
Query: 572 TLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYEC 751
L++++ SP + + YA AG +A+EVL+SIRTV+AF G+E E
Sbjct: 209 ALVILATSPVLTLASAMFSRIVVSLTTKELAAYAKAGAVAQEVLSSIRTVVAFGGEEKEI 268
Query: 752 KRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGR-LESGTVLT 928
KRY + L+ K GIKKS L YA+Y + FW GT V G V+
Sbjct: 269 KRYTENLKQAKDIGIKKSIASQFALGLVNGAFYATYGVGFWYGTTLVLEDDDYTIGDVMA 328
Query: 929 VFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRIS 1108
VFF+V S A+GQA F A AA+S+++VI + ID +S +G P I G I
Sbjct: 329 VFFNVSFSSYAIGQAASHFEAFHIARAAASSIFKVIKQSSSIDNFSNDGFKPDNIKGNIE 388
Query: 1109 VNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILI 1288
+ + F+YP+R VK+L G++L + GQTVALVG SGCGKSTI+QLLQR Y+P G + +
Sbjct: 389 LKDIYFSYPSRPGVKVLNGLNLSVKSGQTVALVGQSGCGKSTIVQLLQRLYDPKEGTLAV 448
Query: 1289 DDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFI 1468
D I+ N+ Y R+L+GVVSQEP LF T+I+QNIRYGR DV+DE+I +A+KEANA DFI
Sbjct: 449 DGHDIKSLNVTYYRELIGVVSQEPVLFGTTIKQNIRYGRDDVTDEEIEKAVKEANAYDFI 508
Query: 1469 KTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSAL 1648
P+ TLVG+RG Q+SGGQKQRIA+ARALVRNPKILLLDEATSALD SE++VQ+AL
Sbjct: 509 MALPDKYETLVGERGAQLSGGQKQRIAVARALVRNPKILLLDEATSALDTGSEAVVQAAL 568
Query: 1649 ENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFAD 1828
+ A +GRTTIV+AHRLST+ AD I+V+ G V E GTH L+E+KG+Y L AQ
Sbjct: 569 DKARKGRTTIVVAHRLSTIWTADVIVVIDNGAVAEQGTHSELMEKKGIYFSLATAQTVQL 628
Query: 1829 VDDKP-----------KKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXX 1975
DD +K +R + QTS + + + +E +
Sbjct: 629 SDDNETTEKNQNGIIYEKASLIQRFNSQTSLKSKILEDEDEEEE---------------- 672
Query: 1976 XXXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINV 2155
+ F++L+ R EW Y + G+++P F +F+++II V
Sbjct: 673 ---------SKKDLPTVSFFQLLKLNRSEWPYILLGIIAAGVIGSLLPLFCIFYARIIAV 723
Query: 2156 FSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQ 2335
F++ D + ++K+ +L+F + V + + + +FG + E LTMR+R ++ +++Q
Sbjct: 724 FASNDPETIRKESDLCSLIFGLTGVVILLAYIARGYMFGRSGETLTMRLRHMAFKAMIQQ 783
Query: 2336 DATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAF 2515
D +FD ++ G +TTRLATDA I++A YRLG + + + + IAF YGW++A
Sbjct: 784 DIAWFDDKDNNTGALTTRLATDASEIQTATGYRLGFLAENLIGIVLTVIIAFVYGWELAL 843
Query: 2516 LVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNI 2695
L +A+ PFM + L G AT D K+++ AGK A EA++NIRT+ +LT + +
Sbjct: 844 LGLAMAPFMVICGLLEFSALTGFATRDKKQLQRAGKIATEAVDNIRTLVSLTRERTFEEM 903
Query: 2696 FCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRV 2875
+ L P+ ++ KA I GL + ++ +FT+AA F FG +LI K + E L V
Sbjct: 904 YSESLQKPYRNSLRKAQIYGLYFAIGHAFYYFTHAALFCFGAYLI--KYERINVEEALLV 961
Query: 2876 LFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKL 3052
I+F T+G ++ P+Y KAT AA +F + E +P ID + G P SG ++
Sbjct: 962 FSVITFGAMTLGTTLTFAPDYAKATSAARYLFALFESKPAIDSSSQQGQKPDCFSGSLEF 1021
Query: 3053 NKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVD 3232
V F YP R V +L+ L V V+ GQT+A VG SGCGKST + LL+R YDP EG V +D
Sbjct: 1022 RNVSFNYPTRSDVRVLRDLCVKVESGQTVAFVGSSGCGKSTSVQLLQRFYDPKEGEVLLD 1081
Query: 3233 NNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKF 3412
+ D + N + LR + +VSQEP+LFD SI ENI YG + ++I++A ANIH F
Sbjct: 1082 DVDAKCFNVQWLRSQMGIVSQEPVLFDCSIAENIAYGDNSRTVSMDEIQSAAKAANIHSF 1141
Query: 3413 IDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVA 3592
I+ LP YET VG KGTQLSGGQKQRIAIARALIR PKILLLDEATSALD ESEK VQ A
Sbjct: 1142 IEGLPLKYETLVGAKGTQLSGGQKQRIAIARALIRAPKILLLDEATSALDNESEKVVQQA 1201
Query: 3593 LDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQS 3766
LD A K RTCI++AHRL+T+ NA I+V+ G+++E G+H EL+AK GAY+ L Q+
Sbjct: 1202 LDQARKGRTCILIAHRLTTVQNADIIVVMNKGKIIEHGSHQELLAKCGAYYDLVNAQA 1259
>gi|39594784|emb|CAE70652.1| Hypothetical protein CBG17357
[Caenorhabditis briggsae]
Length = 1268
Score = 951 bits (2459), Expect = 0.0
Identities = 509/1251 (40%), Positives = 749/1251 (59%), Gaps = 9/1251 (0%)
Frame = +2
Query: 44 SIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTAS 223
+ F ++R + D ++A GII+S G +P S+I F + ++ +
Sbjct: 30 NFFDVFRDSDWRDYALVAGGIILSAVNGALVPFNSLI-------FEGIANALMEGEAQYQ 82
Query: 224 EKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQ 403
FS E+ CL+Y YLG +F + +C +CE+ + R+ + SV+RQ
Sbjct: 83 NGTLNMPWFSSEIKFFCLRYFYLGLALFLCSYCANACLYTLCERRLHCIRKHYLKSVLRQ 142
Query: 404 EIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIM 583
+ W+D++T G L+ K+ +E++++G GDK+G+ +A FI G ++ F W LTL+M
Sbjct: 143 DAKWFDQHTIGGLTQKMSSGIEKIKDGIGDKIGVIVGGVATFISGVSLGFYMCWQLTLVM 202
Query: 584 MSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYE 763
+ P + Y+ AGG+A EV+ IRTV+AFN Q +E RY
Sbjct: 203 LITVPLQLGSMYLSAKHLNRATKNEMSAYSNAGGMANEVIAGIRTVMAFNAQPFEINRYS 262
Query: 764 DALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSV 943
LE +K G++K+ ++ + ++++ +AFW G +G + SG V VF++V
Sbjct: 263 QQLEEARKMGVRKAMILAICTSFPLMLMFTCMAVAFWYGATLAAAGAVSSGAVFAVFWAV 322
Query: 944 MMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVE 1123
++G+ +G+A I A A +++VID PEI S++G+ P KI G++S + +E
Sbjct: 323 LIGTRRIGEAAPHLGAITGARLAIHDIFKVIDHEPEIKCTSSDGKIPDKIQGKLSFDGIE 382
Query: 1124 FTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPI 1303
FTYPTR D+KILKGVS + PG+TVALVG SGCGKST I LL RFYN AG I +D +PI
Sbjct: 383 FTYPTRPDLKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQGAGMIKLDGVPI 442
Query: 1304 EDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPE 1483
++NI++LR +G+V QEP +F ++ +NIR G ++D+DI A + ANA +FI +
Sbjct: 443 HEYNIRWLRSTIGIVQQEPIIFVATVAENIRMGDDLITDDDIEEACRMANAHEFICKLSD 502
Query: 1484 GLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASR 1663
NT++G VQ+SGGQKQR+AIARA+VR P+ILLLDEATSALD ESE +VQ+AL+ AS+
Sbjct: 503 KYNTVIGAGAVQLSGGQKQRVAIARAIVRRPQILLLDEATSALDTESERMVQAALDKASK 562
Query: 1664 GRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLI-EQKGLYHELVHAQVFADVDDK 1840
GRTT+ IAHRLST++NA KI+V G + E GTH+ LI ++ G+Y +V AQ +
Sbjct: 563 GRTTLCIAHRLSTIKNASKILVFDQGLIAERGTHDELISKEDGIYASMVAAQEIERAKED 622
Query: 1841 PKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXX--------XXXX 1996
+ E + R + + +E Q
Sbjct: 623 TTLDDEEDEKDHRMFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPEWEIESARE 682
Query: 1997 XXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRD 2176
GA++A+L I ++A PE LI+G PAFS+ + Q+ + S D
Sbjct: 683 EMIEEGAMEASLVDIFKFASPEGRNIIIALVFTLIRGLTWPAFSIVYGQLFRILS-AGGD 741
Query: 2177 QMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDM 2356
+ +L FL+LA G S L L G A E ++ R+R V+RN+++QDA+YFD
Sbjct: 742 DVSIKALLNSLWFLLLAFTSGISTLVSGGLLGKAGETMSGRLRMDVFRNIMQQDASYFDD 801
Query: 2357 PKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFP 2536
PKH+ G +T+RLATDAPN+++AID RL + + S+ G+ +AF+YGW MA + +A
Sbjct: 802 PKHNVGALTSRLATDAPNVQAAIDQRLAEVLTGVVSLFCGVSVAFFYGWNMAPIGLATAL 861
Query: 2537 FMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDA 2716
+ V Q+ + +Y D A + E+I N +TVQ+LT Q +Y+ F + +
Sbjct: 862 LLVVVQSAVAQYLKFRGQRDMDSAIEASRLVTESISNWKTVQSLTKQEYMYDSFVAASKS 921
Query: 2717 PHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFS 2896
PH I + + + L++ A S + +A A+ FGL+LI N P V +V+ A++ +
Sbjct: 922 PHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLI--SNGWSTPYTVFQVIEALNMA 979
Query: 2897 FGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVFFRYP 3076
++ AASYFPEY++A +AG++F M+ + ID +G P + G++ + +V+F YP
Sbjct: 980 SMSVMLAASYFPEYVRARISAGIMFTMIRQRSVIDNRGLTGDTPPIKGDISMREVYFAYP 1039
Query: 3077 ERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMN 3256
R +L N+ K GQT+ALVGPSGCGKST I L+ER YD L G + VD D+R+++
Sbjct: 1040 NRRRQLVLDSFNMTAKFGQTVALVGPSGCGKSTTIQLIERYYDALSGKIKVDGCDIREIS 1099
Query: 3257 PKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGY 3436
KHLR +IALV QEP LF+ +IRENI YGL+ + + E++E A + ANIH F+ LP+GY
Sbjct: 1100 VKHLRDNIALVGQEPTLFNLTIRENITYGLE--KISQEEVEKAATLANIHTFVMGLPEGY 1157
Query: 3437 ETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDR 3616
+T VG G +LSGGQKQR+AIARA++R+PKILLLDEATSALDTESEK VQ ALD A R
Sbjct: 1158 DTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGR 1217
Query: 3617 TCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSS 3769
TCIV+AHRLSTI NA I+V +NG+ +E+GTH L+A+RG Y+ L +KQS+
Sbjct: 1218 TCIVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQST 1268
>gi|283552|pir||S27338 P-glycoprotein C - Caenorhabditis elegans
gi|6811|emb|CAA46191.1| P-glycoprotein C [Caenorhabditis elegans]
Length = 1254
Score = 942 bits (2434), Expect = 0.0
Identities = 513/1251 (41%), Positives = 742/1251 (59%), Gaps = 9/1251 (0%)
Frame = +2
Query: 44 SIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTAS 223
+ F ++R D ++ + G+I+S G +P S+I F + ++ S
Sbjct: 30 NFFDVFRDADYKDYILFSGGLILSAVNGALVPFNSLI-------FEGIANALMEGESQYQ 82
Query: 224 EKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQ 403
FS E+ CL+Y YLG +F + SC +CE+ + R+++ SV+RQ
Sbjct: 83 NGTINMPWFSSEIKMFCLRYFYLGVALFLCSYFANSCLYTLCERRLHCIRKKYLKSVLRQ 142
Query: 404 EIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIM 583
+ W+D+ T G L+ K+ +E++++G GDKVG+ +A FI G ++ F W LTL+M
Sbjct: 143 DAKWFDETTIGGLTQKMSSGIEKIKDGIGDKVGVLVGGVATFISGVSIGFYMCWQLTLVM 202
Query: 584 MSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYE 763
M P + Y+ AGG+A EV+ IRTV+AFN Q +E RY
Sbjct: 203 MITVPLQLGSMYLSAKHLNRATKNEMSAYSNAGGMANEVIAGIRTVMAFNAQPFEINRYA 262
Query: 764 DALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSV 943
L ++ GI+K+ ++ A ++++ +AFW G +G + SG V VF++V
Sbjct: 263 HQLNEARRMGIRKAIILAICTAFPLMLMFTCMAVAFWYGATLAAAGAVSSGAVFAVFWAV 322
Query: 944 MMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVE 1123
++G+ LG+A I A A +++VID PEI S+EG+ P KI G+++ + +E
Sbjct: 323 LIGTRRLGEAAPHLGAITGARLAIHDIFKVIDHEPEIKCTSSEGKIPEKIQGKLTFDGIE 382
Query: 1124 FTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPI 1303
FTYPTR ++KILKGVS + PG+TVALVG SGCGKST I LL RFYN AG I +D IPI
Sbjct: 383 FTYPTRPELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPI 442
Query: 1304 EDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPE 1483
+++NI++LR +G+V QEP +F ++ +NIR G ++D+DI A K ANA +FI +
Sbjct: 443 QEYNIRWLRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSD 502
Query: 1484 GLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASR 1663
+T++G VQ+SGGQKQR+AIARA+VR P+ILLLDEATSALD ESE +VQ+AL+ AS
Sbjct: 503 RYDTVIGAGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASE 562
Query: 1664 GRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLI-EQKGLYHELVHAQVFADVDDK 1840
GRTT+ IAHRLST+RNA TH+ LI + G+Y +V AQ +
Sbjct: 563 GRTTLCIAHRLSTIRNA--------------STHDELISKDDGIYASMVKAQEIERAKED 608
Query: 1841 PKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXX--------XXXX 1996
+ E + ++ R + + +E Q
Sbjct: 609 TTLDDEEDEKTHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPEWEIENARE 668
Query: 1997 XXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRD 2176
GA++A+LF I +YA PE LI+G PAFS+ + Q+ + S D
Sbjct: 669 EMIEEGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILS-AGGD 727
Query: 2177 QMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDM 2356
+ +L F++LA G S L SL G A E ++ R+R V+RN+++QDA+YFD
Sbjct: 728 DVSIKALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDD 787
Query: 2357 PKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFP 2536
+H+ G +T+RLATDAPN+++AID RL + I S+ G+G+AFYYGW MA + +A
Sbjct: 788 SRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGLATEL 847
Query: 2537 FMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDA 2716
+ V Q+ + +Y D A + E+I N +TVQALT Q +Y+ F + +
Sbjct: 848 LLVVVQSSVAQYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKS 907
Query: 2717 PHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFS 2896
PH I + + + L++ A S + +A A+ FGL+LI N P V +V+ A++ +
Sbjct: 908 PHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLI--SNNWSTPYTVFQVIEALNMA 965
Query: 2897 FGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVFFRYP 3076
++ AASYFPEY++A +AG++F M+ ++ ID +G P + G + + V+F YP
Sbjct: 966 SMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFAYP 1025
Query: 3077 ERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMN 3256
R +L G N+ GQT+ALVGPSGCGKST I L+ER YD L G+V +D++D+R ++
Sbjct: 1026 NRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLS 1085
Query: 3257 PKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGY 3436
KHLR +IALV QEP LF+ +IRENI YGL+ T +Q+E A + ANIH F+ LPDGY
Sbjct: 1086 VKHLRDNIALVGQEPTLFNLTIRENITYGLE--NITQDQVEKAATLANIHTFVMGLPDGY 1143
Query: 3437 ETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDR 3616
+T VG G +LSGGQKQR+AIARA++R+PKILLLDEATSALDTESEK VQ ALD A R
Sbjct: 1144 DTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGR 1203
Query: 3617 TCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSS 3769
TC+V+AHRLSTI NA I+V +NG+ +E+GTH L+A+RG Y+ L +KQSS
Sbjct: 1204 TCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS 1254
>gi|27656758|gb|AAO20902.1| Mdr2 [Takifugu rubripes]
Length = 1271
Score = 938 bits (2424), Expect = 0.0
Identities = 540/1313 (41%), Positives = 732/1313 (55%), Gaps = 89/1313 (6%)
Frame = +2
Query: 110 VSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHEVIQNCLKYVY 289
++ G+ PLM I+ G ++ +F+ + + N++ A + ++ + + Y
Sbjct: 1 MAIVNGLVNPLMCIVFGEMTDSFIQEAKLSQNHNTS---NPRANSTLEADMQRFSIYYSI 57
Query: 290 LGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYDKNTSGTLSNKLFD--- 460
LG + +LQ S + + + + R R FFH +M+Q+I+WYD +G L+ +L +
Sbjct: 58 LGFAVLVVAYLQMSLWTLTAARQAKRIRELFFHGIMQQDISWYDVTETGELNTRLTEWVT 117
Query: 461 --------------------------NLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYD 562
++ +++EG GDK GL Q + FI F + F +
Sbjct: 118 HIIHTPVPVTAGVVVIICGVRFPGAHDVYKIQEGIGDKAGLLIQAASTFITSFVIGFVHG 177
Query: 563 WLLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQE 742
W LTL+++++SP + + YA AG +A EVL+SIRTV AF+GQ
Sbjct: 178 WKLTLVILAISPVLGLSAALYSKLLTSFTSKEQTAYAKAGAVAAEVLSSIRTVFAFSGQR 237
Query: 743 YECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTV 922
KRY LE + GIKK F++IY SY LAFW GT V + G +
Sbjct: 238 KAIKRYHKNLEDARDMGIKKGVAANTATGFSFLMIYLSYALAFWYGTTLVLNKEYTIGNL 297
Query: 923 LT----------------VFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEI 1054
LT VFF V+ G+ +GQA + +A GAA +Y +ID P I
Sbjct: 298 LTNKSVAAETVTTCVQMKVFFVVLYGAYIIGQASPNVQSFASARGAAYKVYNIIDHKPNI 357
Query: 1055 DAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKST 1234
D++S +G P I G I + F+YP+R ++KIL +S + GQT+ALVGSSGCGKST
Sbjct: 358 DSFSEDGYKPEYIKGDIVFQNIHFSYPSRPEIKILNDMSFHVRNGQTIALVGSSGCGKST 417
Query: 1235 IIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDV 1414
IQLLQRFY+P G I ID I NI+YLR+++GVVSQEP LF T+I +NIRYGR DV
Sbjct: 418 TIQLLQRFYDPQKGSIFIDGHDIRSLNIRYLREMIGVVSQEPVLFATTITENIRYGRLDV 477
Query: 1415 SDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLD 1594
+ E+I RA KE+NA DFI P+ TLVGDRG Q+SGGQKQRIAIARALVRNPKILLLD
Sbjct: 478 TQEEIERATKESNAYDFIMNLPDKFETLVGDRGTQLSGGQKQRIAIARALVRNPKILLLD 537
Query: 1595 EATSALDAESESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETL 1774
EATSALDAESE+IVQ+AL+ GRTTIVIAHRLST+RNAD I G+++E GTH L
Sbjct: 538 EATSALDAESETIVQAALDKVRLGRTTIVIAHRLSTIRNADIIAGFSNGEIVEQGTHSQL 597
Query: 1775 IEQKGLYHELVHAQVFADVDD---------KPKKKEAERRMSRQTSQRKGSVNFKTQESQ 1927
+E KG+YH LV Q F ++D +K + S+ + QR+ S ++
Sbjct: 598 MEIKGVYHGLVTMQSFQKLEDLEDSDYEPWVAEKSQLIESFSQSSLQRRRS-------TR 650
Query: 1928 VDXXXXXXXXXXXXXXXXXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQG 2107
+ FK++RY EW Y +I G
Sbjct: 651 GSLLAVSEGTKEEKEKFECDQDNIEEDENVPPVSFFKVMRYNVSEWPYILVGTICAMING 710
Query: 2108 AVMPAFSLFFSQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAER 2287
A+ P FS+ F++II FW FQ F + E
Sbjct: 711 AMQPVFSIIFTEII---------------MFWG---------------FQGFCFSKSGEI 740
Query: 2288 LTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASV 2467
LT+ +R K + +++RQD +++D PK++ G +TTRLA DA +++ A RL + A++
Sbjct: 741 LTLNLRLKAFISMMRQDLSWYDNPKNTVGALTTRLAADAAHVQGAAGVRLAVMTQNFANL 800
Query: 2468 GGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIEN 2647
G + I+F YGW++ L++A+ P +AV A +K G A D KE+E AGK A EAIEN
Sbjct: 801 GTSIIISFVYGWELTLLILAVVPILAVAGAAEVKLLTGHAAEDKKELEMAGKIATEAIEN 860
Query: 2648 IRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFL 2827
+RTV +LT + ++ +L P+ + KA I GLTY F+ ++ FF YAA FRFG +L
Sbjct: 861 VRTVVSLTREPTFVALYEENLTVPYKNSQKKAKIYGLTYSFSQAMIFFVYAACFRFGAWL 920
Query: 2828 IFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGM 3007
I + M+ E V V+ + + +G A +Y P + KA +A + ++ +P ID +
Sbjct: 921 I--EAGRMDVEGVFLVVMTMLYGAMAVGEANTYAPNFAKAKISASHLTMLINRQPAIDNL 978
Query: 3008 T-SSGTYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVIS 3184
+ + G V V F YP RP VP+LQGLN+ V+ G+TLALVG SGCGKST I
Sbjct: 979 SEEEARLEKYDGNVLFEDVKFNYPSRPDVPVLQGLNLEVQKGETLALVGSSGCGKSTTIQ 1038
Query: 3185 LLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYT 3364
LLER YDP EG V +D D++Q+N LR I +VSQEP+LFD S+ ENI YG +
Sbjct: 1039 LLERFYDPREGRVLLDGVDVKQLNVHWLRSQIGIVSQEPVLFDCSLAENIAYGDNSRSVS 1098
Query: 3365 HEQIETACSKANIHKFIDELP----------------------------------DGYET 3442
++I A ANIH FI+ LP Y+T
Sbjct: 1099 MDEIVAAAKAANIHSFIEGLPQVAAVNQGKWLIPHLIDSHGAAHDHLHHIQTVSEQRYDT 1158
Query: 3443 RVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTC 3622
+ G+KGTQLSGGQKQR+AIARA+IRNPK+LLLDEATSALDTESEK VQ ALD A K RTC
Sbjct: 1159 QAGDKGTQLSGGQKQRVAIARAIIRNPKLLLLDEATSALDTESEKVVQEALDQARKGRTC 1218
Query: 3623 IVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSSNQSG 3781
IVVAHRLSTI NA CI V + G VVE+GTH +LIAK+G Y L KQ SG
Sbjct: 1219 IVVAHRLSTIQNADCIAVFQGGVVVEKGTHQQLIAKKGVYHMLVTKQMGYHSG 1271
>gi|14030565|gb|AAK52958.1| bile salt export pump [Raja erinacea]
Length = 1348
Score = 903 bits (2334), Expect = 0.0
Identities = 510/1285 (39%), Positives = 729/1285 (56%), Gaps = 48/1285 (3%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTL----------- 187
I FQL+R+ S + ++ G + + GV P + ++ G ++ F+
Sbjct: 62 IGFFQLFRFASCYEVTLMVFGGVCALLHGVAQPAVLLVFGLLTDTFIAYDIELQELKDTR 121
Query: 188 ------------GTIFLDPNSTASEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQAS 331
G+ +L+ ++ E E+ YV +GC + G+ Q
Sbjct: 122 KHCDNNTIHWVNGSEYLNQHNETMSCGILNIE--KEMTMFAYYYVGIGCSVLLLGYFQIC 179
Query: 332 CFMVICEKLSNRFRRQFFHSVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAF 511
++ + + + R+ +F +MR E+ W+D N+ G L+ ++ D++ ++ + D+VG+
Sbjct: 180 FWVTAAARQTQKIRKAYFRQIMRMEMGWFDCNSVGELNTRMSDDINKINDAIADQVGIFI 239
Query: 512 QMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIA 691
Q + F+ GF + F W LTL+++++SP + + YA AG +A
Sbjct: 240 QRFSTFVSGFLMGFVNGWKLTLVIIAVSPLIGLGAALMALSVARLTGLGLKAYAKAGAVA 299
Query: 692 EEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAF 871
+EVL+SIRTV AF+G++ E RY+ L ++ GI+K ++G ++II+ Y LAF
Sbjct: 300 DEVLSSIRTVAAFSGEKKEVDRYDRNLVFAQRWGIRKGMIMGFFTGYVWMIIFCCYALAF 359
Query: 872 WVGTNFVYS-GRLESGTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIP 1048
W G+ V G +L VF V++ +M LGQA + GAA ++E IDR P
Sbjct: 360 WYGSKLVIEQNEYTPGGLLQVFLGVLVAAMNLGQASPCLEAFASGRGAAVKIFETIDREP 419
Query: 1049 EIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGK 1228
EID S G T +K+ G I + V F YP+R DVK L +S+ + G+T A VG SG GK
Sbjct: 420 EIDCMSEGGYTLNKVKGDIEFHNVTFNYPSRPDVKTLDRLSMVIKAGETTAFVGPSGSGK 479
Query: 1229 STIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRS 1408
ST ++L+QRFY+P G + +D I NI++LR L+G+V QEP LF+T+IE+NIRY R
Sbjct: 480 STAVELIQRFYDPKQGMVTLDGHDIRSLNIQWLRSLIGIVEQEPVLFSTTIEENIRYVRE 539
Query: 1409 DVSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILL 1588
++ DI +A KEANA DFI PE NTLVG+ G QMSGGQKQRIAIARALVRNPKILL
Sbjct: 540 GLTKNDIVQAAKEANAYDFIMDLPEKFNTLVGEGGGQMSGGQKQRIAIARALVRNPKILL 599
Query: 1589 LDEATSALDAESESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHE 1768
LD ATSALD ESE+IVQ AL+ GRTTI IAHRLSTVRN D II + G+ +E G H
Sbjct: 600 LDMATSALDNESEAIVQGALDKVRFGRTTISIAHRLSTVRNVDVIIGFEHGRAVERGRHA 659
Query: 1769 TLIEQKGLYHELVHAQVFADV--------------DDKPKKKEAERRMSRQTSQRKGSVN 1906
L+E+KG+Y LV Q + D +K++ RR S + S R S
Sbjct: 660 ELLERKGIYFTLVTLQTQGEQALHEKARQVNGAIEDGASEKRQLIRRGSSRASVR--STR 717
Query: 1907 FKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXX---------GAVKANLFKILRYARP 2059
+ SQV A + +IL+Y
Sbjct: 718 HQRSRSQVSEVLSDLSGPGDVASAVRTPSISLGDEDKDVEEEEESIEPAPVSRILKYNVS 777
Query: 2060 EWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQG 2239
EW Y + G V P ++L FSQI+ FS + ++ + L F+V+ V
Sbjct: 778 EWPYMLFGSLGAAVNGGVNPIYALLFSQILGTFSLQNEEEKINQINAICLFFVVVGLVSF 837
Query: 2240 TSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKS 2419
+ Q F + E LT R+R ++ +LRQ+ +FD K+SPG +TTRLATDA ++
Sbjct: 838 LTQFLQSYFFAKSGELLTRRLRKLGFQAMLRQEIGWFDDRKNSPGTLTTRLATDASQVQG 897
Query: 2420 AIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDA 2599
A ++G I N+I ++G L IAFY+ W++ +++ PF+A+ AL + G A D
Sbjct: 898 ATGTQIGMIVNSITNIGVSLIIAFYFSWKLTLVILCFLPFLALTGALQARMLTGFANQDK 957
Query: 2600 KEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANS 2779
+ +E AG+ + EA+ NIRT+ L + +F + L+AP+ I KA + GL +GFA S
Sbjct: 958 EALEAAGQISSEALSNIRTIAGLAKEKMFVQLFEAQLEAPYKAAIKKANVYGLCFGFAQS 1017
Query: 2780 IQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAA 2959
+ F AA++RFG +L+ +N+ V RV+ AI S +G A+SY P+Y KA AA
Sbjct: 1018 VIFLANAASYRFGGYLVVAENLHFSI--VFRVISAIVTSGTALGRASSYTPDYAKAKIAA 1075
Query: 2960 GLIFNMLEEEPRIDGMTSSGT-YPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQT 3136
F +++ P+I+ +S G + G++K + F YP RP +L GL+V V PGQT
Sbjct: 1076 ARFFQLIDRAPKINIDSSEGEKWSNFRGDIKFVECTFTYPTRPDFQVLNGLSVCVMPGQT 1135
Query: 3137 LALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDT 3316
LA VG SGCGKST + LLER YDP +G V +D +N LR I +VSQEP+LFD+
Sbjct: 1136 LAFVGSSGCGKSTSVQLLERFYDPNQGRVIIDGRSTTNVNTAFLRSKIGIVSQEPVLFDS 1195
Query: 3317 SIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIA 3496
SI ENI YG + + +++ A KA +H F+ LP+ Y TRVG +G+QLS GQKQRIA
Sbjct: 1196 SIEENIKYGDNSRQVSMDEVIAAAKKAQLHSFVMSLPEKYGTRVGAQGSQLSRGQKQRIA 1255
Query: 3497 IARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMV 3676
IARA++R+PKILLLDEATSALDTESEK VQ ALD A K RTCIV+AHRLSTI N+ I V
Sbjct: 1256 IARAIVRDPKILLLDEATSALDTESEKIVQDALDEARKGRTCIVIAHRLSTIQNSDIIAV 1315
Query: 3677 VKNGQVVEQGTHNELIAKRGAYFAL 3751
+ G ++EQG+H L+A +GAY+ L
Sbjct: 1316 MSRGIIIEQGSHGNLMAAKGAYYKL 1340
Score = 375 bits (963), Expect = e-102
Identities = 218/560 (38%), Positives = 324/560 (56%), Gaps = 4/560 (0%)
Frame = +2
Query: 140 LMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGF 319
L + + G V+ + L + L S +E+ E +++ CL +V +G F F
Sbjct: 787 LGAAVNGGVNPIYALLFSQILGTFSLQNEE-----EKINQINAICLFFVVVGLVSFLTQF 841
Query: 320 LQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYD--KNTSGTLSNKLFDNLERVREGTGD 493
LQ+ F E L+ R R+ F +++RQEI W+D KN+ GTL+ +L + +V+ TG
Sbjct: 842 LQSYFFAKSGELLTRRLRKLGFQAMLRQEIGWFDDRKNSPGTLTTRLATDASQVQGATGT 901
Query: 494 KVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYA 673
++G+ + +AF + W LTL+++ PF+ + G
Sbjct: 902 QIGMIVNSITNIGVSLIIAFYFSWKLTLVILCFLPFLALTGALQARMLTGFANQDKEALE 961
Query: 674 VAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYA 853
AG I+ E L++IRT+ ++ + +E LE K IKK+ + G +I+
Sbjct: 962 AAGQISSEALSNIRTIAGLAKEKMFVQLFEAQLEAPYKAAIKKANVYGLCFGFAQSVIFL 1021
Query: 854 SYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEV 1033
+ ++ G V + L V V +++ ALG+A A AAA +++
Sbjct: 1022 ANAASYRFGGYLVVAENLHFSIVFRVISAIVTSGTALGRASSYTPDYAKAKIAAARFFQL 1081
Query: 1034 IDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGS 1213
IDR P+I+ S+EG+ S G I + FTYPTR D ++L G+S+ PGQT+A VGS
Sbjct: 1082 IDRAPKINIDSSEGEKWSNFRGDIKFVECTFTYPTRPDFQVLNGLSVCVMPGQTLAFVGS 1141
Query: 1214 SGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNI 1393
SGCGKST +QLL+RFY+P+ G+++ID + N +LR +G+VSQEP LF++SIE+NI
Sbjct: 1142 SGCGKSTSVQLLERFYDPNQGRVIIDGRSTTNVNTAFLRSKIGIVSQEPVLFDSSIEENI 1201
Query: 1394 RYGRS--DVSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALV 1567
+YG + VS +++ A K+A F+ + PE T VG +G Q+S GQKQRIAIARA+V
Sbjct: 1202 KYGDNSRQVSMDEVIAAAKKAQLHSFVMSLPEKYGTRVGAQGSQLSRGQKQRIAIARAIV 1261
Query: 1568 RNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQV 1747
R+PKILLLDEATSALD ESE IVQ AL+ A +GRT IVIAHRLST++N+D I VM G +
Sbjct: 1262 RDPKILLLDEATSALDTESEKIVQDALDEARKGRTCIVIAHRLSTIQNSDIIAVMSRGII 1321
Query: 1748 MEVGTHETLIEQKGLYHELV 1807
+E G+H L+ KG Y++LV
Sbjct: 1322 IEQGSHGNLMAAKGAYYKLV 1341
Score = 336 bits (862), Expect = 2e-90
Identities = 199/509 (39%), Positives = 289/509 (56%), Gaps = 1/509 (0%)
Frame = +2
Query: 2252 FQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDY 2431
FQ + AA R T +IR +R ++R + +FD +S G + TR++ D I AI
Sbjct: 176 FQICFWVTAAARQTQKIRKAYFRQIMRMEMGWFDC--NSVGELNTRMSDDINKINDAIAD 233
Query: 2432 RLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEME 2611
++G ++ G + F GW++ +++A+ P + +G ALM K
Sbjct: 234 QVGIFIQRFSTFVSGFLMGFVNGWKLTLVIIAVSPLIGLGAALMALSVARLTGLGLKAYA 293
Query: 2612 NAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFF 2791
AG A E + +IRTV A + + K + + +L I K +I G G+ I F
Sbjct: 294 KAGAVADEVLSSIRTVAAFSGEKKEVDRYDRNLVFAQRWGIRKGMIMGFFTGYVWMIIFC 353
Query: 2792 TYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIF 2971
YA AF +G L+ ++N P +L+V + + +G A+ + AA IF
Sbjct: 354 CYALAFWYGSKLVIEQNEYT-PGGLLQVFLGVLVAAMNLGQASPCLEAFASGRGAAVKIF 412
Query: 2972 NMLEEEPRIDGMTSSG-TYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALV 3148
++ EP ID M+ G T ++ G+++ + V F YP RP V L L++ +K G+T A V
Sbjct: 413 ETIDREPEIDCMSEGGYTLNKVKGDIEFHNVTFNYPSRPDVKTLDRLSMVIKAGETTAFV 472
Query: 3149 GPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRE 3328
GPSG GKST + L++R YDP +G VT+D +D+R +N + LR I +V QEP+LF T+I E
Sbjct: 473 GPSGSGKSTAVELIQRFYDPKQGMVTLDGHDIRSLNIQWLRSLIGIVEQEPVLFSTTIEE 532
Query: 3329 NIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARA 3508
NI Y ++ G T I A +AN + FI +LP+ + T VGE G Q+SGGQKQRIAIARA
Sbjct: 533 NIRY-VREG-LTKNDIVQAAKEANAYDFIMDLPEKFNTLVGEGGGQMSGGQKQRIAIARA 590
Query: 3509 LIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNG 3688
L+RNPKILLLD ATSALD ESE VQ ALD RT I +AHRLST+ N I+ ++G
Sbjct: 591 LVRNPKILLLDMATSALDNESEAIVQGALDKVRFGRTTISIAHRLSTVRNVDVIIGFEHG 650
Query: 3689 QVVEQGTHNELIAKRGAYFALTQKQSSNQ 3775
+ VE+G H EL+ ++G YF L Q+ +
Sbjct: 651 RAVERGRHAELLERKGIYFTLVTLQTQGE 679
>gi|22026798|ref|NP_523740.2| CG8523-PA [Drosophila melanogaster]
gi|21645421|gb|AAF58271.2| CG8523-PA [Drosophila melanogaster]
Length = 1287
Score = 896 bits (2316), Expect = 0.0
Identities = 509/1269 (40%), Positives = 731/1269 (57%), Gaps = 27/1269 (2%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+S FQL+RY + DR + +G++ + ATG+ P S+I GN++ + + LG + S
Sbjct: 45 VSYFQLFRYATKKDRALYVIGLLSAVATGLTTPANSLIFGNLANDMIDLGGLLESGKSYR 104
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
++ A + +V Q L+ Y+G + +L +CF R +FF S++
Sbjct: 105 ADDAISTLLLD-KVRQFSLQNTYIGIIMLVCSYLSITCFNYAAHSQILTIRSKFFRSILH 163
Query: 401 QEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLI 580
Q++ WYD N SG +++++ ++L ++ +G +KV + + F+G +AF W L+L+
Sbjct: 164 QDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLV 223
Query: 581 MMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRY 760
++ P I YA A +AE L+ IRTV AF G+ E Y
Sbjct: 224 CLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAY 283
Query: 761 EDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSG-------RLESGT 919
++ + K IK++ G G + IYASY LAFW G V G ++GT
Sbjct: 284 KERVVAAKILNIKRNMFSGIGFGLLWFFIYASYALAFWYGVGLVIKGYHEPAYENYDAGT 343
Query: 920 VLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISG 1099
++TVFFSVMMGSM +G A G A GA A ++ +I++IPEI+ EG+ ++
Sbjct: 344 MITVFFSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEINPIDGEGKKLNEPLT 403
Query: 1100 RISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQ 1279
I +VEF YPTR +V IL ++L GQTVALVG SGCGKST IQL+QRFY+P AG
Sbjct: 404 TIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGN 463
Query: 1280 ILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAA 1459
+L + ++D +I +LR +GVV QEP LF TSI +NIRYGR D + E+I A ANAA
Sbjct: 464 LLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGREDATREEIEAAAAAANAA 523
Query: 1460 DFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQ 1639
FIK P+G +TLVG+RG Q+SGGQKQRIAIARAL+R+P+ILLLDEATSALD SE+ VQ
Sbjct: 524 IFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQ 583
Query: 1640 SALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQ- 1816
+ALE S GRTTI++AHRLSTVR AD+I+V+ G+V+E GTH+ L+E K Y LV Q
Sbjct: 584 AALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLVTTQL 643
Query: 1817 -------------VFADVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXX 1957
++ + D K + +E + +S + + K ++ +
Sbjct: 644 GEDDGSVLSPTGDIYKNFDIKDEDEEEIKVLSEDEDEDVMVTDEKNKKKK---------- 693
Query: 1958 XXXXXXXXXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFF 2137
VK + ++++ +PEW+ +I G MP F++ F
Sbjct: 694 -----------KKKVKDPNEVKP-MLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLF 741
Query: 2138 SQIINVFSNPDRDQ-MKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKV 2314
I+ + S D DQ ++++ + ++L FL+ V G + Q FG+A ERLT R+R +
Sbjct: 742 GSILQILSVKDNDQYVRENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLM 801
Query: 2315 YRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFY 2494
+ +LRQ+ +FD + G + RL+ DA ++ A R+G+I +I+++ G+ ++ Y
Sbjct: 802 FEAMLRQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMY 861
Query: 2495 YGWQMAFLVMAIFPFMAVG----QALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQ 2662
Y W + + +A PF+ + + LM K + GS AK MEN K A+E + NIRTV
Sbjct: 862 YEWSLGLVALAFTPFILIAFYMQRTLMAKENMGS----AKTMENCTKLAVEVVSNIRTVA 917
Query: 2663 ALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKN 2842
+L + + + L + RGL YG A S+ FF YAA +G + + +
Sbjct: 918 SLGREEMFHQNYIGMLIPAVEISKRNTHFRGLVYGLARSLMFFAYAACMYYGTWCVIHRG 977
Query: 2843 VLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGT 3022
+L +V +V A+ +I A ++ P K AA IF L +P I
Sbjct: 978 ILF--GDVFKVSQALIMGTASIANALAFAPNMQKGVSAAKTIFTFLRRQPSIVDRPGVSR 1035
Query: 3023 YPQLS-GEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERL 3199
P S G V+ +KV F YP R + +L+GL + V GQ +ALVGPSGCGKST I L++R
Sbjct: 1036 DPWHSEGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRF 1095
Query: 3200 YDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIE 3379
YD EGA +D D+R ++ +LR + +VSQEPILFD +IRENI YG T ++I
Sbjct: 1096 YDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARNVTDQEII 1155
Query: 3380 TACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSAL 3559
+AC K+NIH+FI LP GY+TR+GEKG QLSGGQKQRIAIARALIRNPKI+LLDEATSAL
Sbjct: 1156 SACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSAL 1215
Query: 3560 DTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGA 3739
D ESEK VQ ALDAA++ RT I +AHRLST+V++ I V +NG V E G H +L+A RG
Sbjct: 1216 DAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLLANRGL 1275
Query: 3740 YFALTQKQS 3766
Y+ L + QS
Sbjct: 1276 YYTLYKLQS 1284
Score = 328 bits (840), Expect = 8e-88
Identities = 216/611 (35%), Positives = 320/611 (52%), Gaps = 24/611 (3%)
Frame = +2
Query: 2021 KANLFKILRYA-RPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGH 2197
+ + F++ RYA + + + G PA SL F + N D + + G
Sbjct: 44 QVSYFQLFRYATKKDRALYVIGLLSAVATGLTTPANSLIFGNLANDMI--DLGGLLESGK 101
Query: 2198 FW----ALMFLVLAAVQGTSM--------LFQCSL-----FGVAAERLTMRIRSKVYRNV 2326
+ A+ L+L V+ S+ + CS F AA + IRSK +R++
Sbjct: 102 SYRADDAISTLLLDKVRQFSLQNTYIGIIMLVCSYLSITCFNYAAHSQILTIRSKFFRSI 161
Query: 2327 LRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQ 2506
L QD ++D + G + +R+ D ++ + ++ + + + G L +AF GWQ
Sbjct: 162 LHQDMKWYDF--NQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQ 219
Query: 2507 MAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKL 2686
++ + + P + L+ A + A A A+ IRTV+A + K
Sbjct: 220 LSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKE 279
Query: 2687 YNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPEN- 2863
+ + A NI + + G+ +G + +YA AF +G+ L+ EN
Sbjct: 280 VAAYKERVVAAKILNIKRNMFSGIGFGLLWFFIYASYALAFWYGVGLVIKGYHEPAYENY 339
Query: 2864 ----VLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGT-YP 3028
++ V F++ IG AA Y + A A +F+++E+ P I+ + G
Sbjct: 340 DAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEINPIDGEGKKLN 399
Query: 3029 QLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDP 3208
+ ++ +V F+YP RP V IL LN+ + GQT+ALVGPSGCGKST I L++R YDP
Sbjct: 400 EPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDP 459
Query: 3209 LEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETAC 3388
G + + +L+ ++ LR I +V QEPILF TSI ENI YG + + T E+IE A
Sbjct: 460 QAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGRE--DATREEIEAAA 517
Query: 3389 SKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTE 3568
+ AN FI +LP GY+T VGE+G QLSGGQKQRIAIARALIR+P+ILLLDEATSALDT
Sbjct: 518 AAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTA 577
Query: 3569 SEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFA 3748
SE +VQ AL+ + RT I+VAHRLST+ A I+V+ G+VVE GTH EL+ + YF
Sbjct: 578 SEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFN 637
Query: 3749 LTQKQSSNQSG 3781
L Q G
Sbjct: 638 LVTTQLGEDDG 648
>gi|50507726|emb|CAA94219.3| Hypothetical protein T21E8.2
[Caenorhabditis elegans]
Length = 1263
Score = 894 bits (2310), Expect = 0.0
Identities = 498/1240 (40%), Positives = 729/1240 (58%), Gaps = 4/1240 (0%)
Frame = +2
Query: 56 LYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAA 235
+++ TS ++ + +G+ S TG+ P +S +G +Q VT+ + ++
Sbjct: 31 IFKCTSCFEKFLFLIGVFFSLVTGLCQPFVSYTLGETAQVLVTITNAINNKTIDPADLKK 90
Query: 236 ARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAW 415
A ++ + Q L + GC F +Q + + + + R R+Q+ ++R++ +
Sbjct: 91 AYEQYERGMYQVVLYFFLCGCAYFTFASIQHAIMKYVGDNTTYRVRKQYISRLLRKDAEY 150
Query: 416 YDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLS 595
+D ++G LS L DNLER RE +K+ L F ++ F+ G A+AF DW L + S
Sbjct: 151 FDNVSTGHLSTVLNDNLERFREVFNEKIALIFALLTDFVVGTALAFYTDWRLASYGIFFS 210
Query: 596 PFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALE 775
+ G YA AG IA + L + +TV + NGQ E +RY + L+
Sbjct: 211 LGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQNTEIERYTEELK 270
Query: 776 HGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGS 955
G+K GI ++ + + + + +VG N +YSG LE V+ +F +M G+
Sbjct: 271 AGEKYGIHRALMYSISRGFTYFFCNSLNTVILYVGANMIYSGSLEPAVVVRIFHYMMFGA 330
Query: 956 MALGQAGQQFATIGTALGAAASLYEVI---DRIPEIDAYSTEGQTPSKISGRISVNKVEF 1126
L +A + + A+ + A + E++ D + E D T+ +++G IS V+F
Sbjct: 331 FCLSEALPHISRLAGAISSTAPIAEMLIKEDNVIEKD--ETDYDVEVEVNGNISFKNVKF 388
Query: 1127 TYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIE 1306
+YPTR D ++LKG+S D Q G+ +ALVG+SG GKST++QLL +YN D+G I ID + +
Sbjct: 389 SYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLN 448
Query: 1307 DFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEG 1486
D NIK LR+++GVVSQEP LFNT+IE+NIR+G +VS +I AL++ANA DF+ +FP+G
Sbjct: 449 DMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKG 508
Query: 1487 LNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRG 1666
+ T+VG+RG Q+SGGQKQRIAIAR LVRNPKILLLDEATSALD ESE +VQ ALENAS+G
Sbjct: 509 IKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQG 568
Query: 1667 RTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVDDKPK 1846
RTTIV+AHRLST+RNA KIIVM+ G+++EVG H+ LI ++G+Y++LV AQ+ DD
Sbjct: 569 RTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLESHDD--- 625
Query: 1847 KKEAERRMSRQTSQRKGSV-NFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXGAVK 2023
+E +RQ SQ + ++ Q S GA K
Sbjct: 626 HEELPPLAARQLSQELSPLHSYAIQRS-------TSNDAGVHDDDMERILDELSKEGAKK 678
Query: 2024 ANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHFW 2203
+NL +I++ RP++ + IQG P + + F+ D M H W
Sbjct: 679 SNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGED-MLYYSHLW 737
Query: 2204 ALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRIT 2383
AL F+ LA + ++ Q FG +E+L+ R+R K + ++L ++D P HS R++
Sbjct: 738 ALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLS 797
Query: 2384 TRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALM 2563
RL TD+ N+K+A+D RLG + + ++ + A Y W+M V+ FP + + +
Sbjct: 798 NRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLIFFPLLYLAEYCY 857
Query: 2564 MKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKA 2743
S D EN+ +TA+EA+EN+RTV+AL L+ K+ ++ HL H +A
Sbjct: 858 DAATETSIQEDTIAFENSNRTAIEALENMRTVRALNLEDKIMSLISEHLQKIHKSYFKRA 917
Query: 2744 IIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAAS 2923
II+G G + S F Y+ +F+FG +L K V P + +L +S + G AA+
Sbjct: 918 IIQGAANGLSLSCYLFVYSVSFKFGTYLALRKEV--APMDTYLILETLSMTANMAGSAAA 975
Query: 2924 YFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVFFRYPERPAVPILQ 3103
Y P+Y KA AAGLIF++ + +S G GE+ V F Y +RP IL
Sbjct: 976 YLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILN 1035
Query: 3104 GLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIA 3283
G+N+ V PG+TLALVGPSGCGKST+ISLLER Y ++G V +D+ ++ +N HLR ++A
Sbjct: 1036 GVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLA 1095
Query: 3284 LVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGT 3463
LVSQEP LF+ SIREN++YGL ++E A AN F+ + P G +T VGE+G
Sbjct: 1096 LVSQEPTLFNCSIRENLLYGL-TRSVPQLELEKALQTANAFNFVFQFPQGLDTIVGERGA 1154
Query: 3464 QLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRL 3643
QLSGGQKQRIAIARA++RNPK+LLLDEATSALD++SEK VQ ALD A++ + +VVAHRL
Sbjct: 1155 QLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRL 1214
Query: 3644 STIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQ 3763
T+VNA I V+KNG+V EQGTH EL+ KR Y+ L QKQ
Sbjct: 1215 LTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 1254
>gi|38073917|ref|XP_283101.2| similar to multidrug resistance
p-glycoprotein [Mus musculus]
Length = 1214
Score = 890 bits (2300), Expect = 0.0
Identities = 478/1162 (41%), Positives = 695/1162 (59%), Gaps = 3/1162 (0%)
Frame = +2
Query: 275 LKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYDKNTSGTLSNKL 454
L Y+ +G G++Q S +++ + + R R+QFFHS++ Q+I+W+D + L+ ++
Sbjct: 68 LYYIGIGAAALIFGYVQISFWVITAARQTTRIRKQFFHSILAQDISWFDGSDICELNTRM 127
Query: 455 FDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXXXX 634
++ ++ +G GDK+ L FQ ++ F G ++ W L+L+++S SP +M
Sbjct: 128 TGDINKLCDGIGDKIPLMFQNISGFSIGLVISLIKSWKLSLVVLSTSPLIMASSALCSRM 187
Query: 635 XXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFLI 814
Y+ AG +AEE L+SI+TV AF QE E +RY L+ K GIK++
Sbjct: 188 IISLTSKELDAYSKAGAVAEEALSSIQTVTAFGAQEKEIQRYTQHLKDAKDAGIKRATAS 247
Query: 815 GAGLASFFVIIYASYCLAFWVGTNFVYSGR--LESGTVLTVFFSVMMGSMALGQAGQQFA 988
L + + + +Y LAFW GT+ ++ G GT+L VFFSV+ S +G
Sbjct: 248 KLSLGAVYFFMNGAYGLAFWYGTSLIFGGEPGYTIGTILAVFFSVIHSSYCIGSVAPHLE 307
Query: 989 TIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKGV 1168
T A GAA ++++VID+ P ID +ST G P I G I V F+YP+R K+LKG+
Sbjct: 308 TFTVARGAAFNIFQVIDKKPNIDNFSTAGFVPECIEGNIEFKNVSFSYPSRPSAKVLKGL 367
Query: 1169 SLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVV 1348
+L + G+TVALVG SG GKST +QLLQR Y+P+ G I +D+ I N+++ R+ +GVV
Sbjct: 368 NLKIKAGETVALVGPSGSGKSTTVQLLQRLYDPEDGCITVDENDIRAQNVRHYREQIGVV 427
Query: 1349 SQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQMSG 1528
QEP LF T+I NI++GR V ++++ +A +EANA DFI FP+ NTLVG++G QMSG
Sbjct: 428 RQEPVLFGTTIGNNIKFGREGVGEKEMEQAAREANAYDFIMAFPKKFNTLVGEKGAQMSG 487
Query: 1529 GQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLSTVR 1708
GQKQRIAIARALVRNPKIL+LDEATSALD ESES+VQ+ALE AS+GRTTIV+AHRLST+R
Sbjct: 488 GQKQRIAIARALVRNPKILILDEATSALDTESESLVQTALEKASKGRTTIVVAHRLSTIR 547
Query: 1709 NADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVDDKPKKKEAERRMSRQTSQ 1888
AD I+ MK G V+E GTH L+ ++GLY+ L AQ VD+ +M +T
Sbjct: 548 GADLIVTMKDGMVVEKGTHAELMAKQGLYYSLAMAQDIKKVDE---------QMESRTCS 598
Query: 1889 RKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXGAVKANLFKILRYARPEWI 2068
G+ ++ + +L KI + ++ EW
Sbjct: 599 TAGNASY--------GSLCDVNSAKAPCTDQLEEAVHHQKTSLPEVSLLKIFKLSKSEWP 650
Query: 2069 YXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSM 2248
+ + G+V P FS+ F +++ +F + ++ +K+D +++M +VL V +
Sbjct: 651 FVVLGTLASALNGSVHPVFSIIFGKLVTMFEDKNKATLKQDAELYSMMLVVLGIVALVTY 710
Query: 2249 LFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAID 2428
L Q +G A E L MR+R ++ +L QD ++D +++ G +TT LA D I+ A
Sbjct: 711 LMQGLFYGRAEENLAMRLRHSAFKAMLYQDMAWYDDKENNTGALTTTLAVDVAQIQGAAT 770
Query: 2429 YRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEM 2608
RLG + ++++ + I+F YGW+M L+++ P +AV + G A D + +
Sbjct: 771 SRLGIVTQDVSNMSLSILISFIYGWEMTLLILSFAPVLAVTGMIQTAAMAGFANRDKQAL 830
Query: 2609 ENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQF 2788
+ AGK A EA+ENIRTV +LT + ++ L H + +A I G Y +++
Sbjct: 831 KRAGKIATEAVENIRTVVSLTRERAFEQMYEETLQTQHRNALKRAHITGCCYAVSHAFVH 890
Query: 2789 FTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLI 2968
F +AA FRFG +LI + M PE + V AI++ IG + PEY KA A +
Sbjct: 891 FAHAAGFRFGAYLI--QAGRMMPEGMFIVFTAIAYGAMAIGETLVWAPEYSKAKAGASHL 948
Query: 2969 FNMLEEEPRIDGMTSSGTYPQ-LSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLAL 3145
F +L+ +P I+ + SG P G ++ +V F YP RP VP+LQ +++ ++ G+T+A
Sbjct: 949 FALLKNKPTINSCSQSGEKPDTCEGNLEFREVSFVYPCRPEVPVLQNMSLSIEKGKTVAF 1008
Query: 3146 VGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIR 3325
VG SGCGKST + LL+R YDP++G V +D D++++N + LR A+VSQEP+LF+ SI
Sbjct: 1009 VGSSGCGKSTCVQLLQRFYDPMKGQVLLDGVDVKELNVQWLRSQTAIVSQEPVLFNCSIA 1068
Query: 3326 ENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIAR 3505
ENI YG E+I+ ANIH FI+ LP Y T VG +G QLSGGQKQR+AIAR
Sbjct: 1069 ENIAYGDNSRMVPLEEIKEVADAANIHSFIEGLPRKYNTLVGLRGVQLSGGQKQRLAIAR 1128
Query: 3506 ALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKN 3685
AL+R PKILLLDEATSALD ESEK VQ ALD A + +TC+VVAHRLSTI NA I+V++N
Sbjct: 1129 ALLRKPKILLLDEATSALDNESEKVVQQALDKARRGKTCLVVAHRLSTIQNADMIVVLQN 1188
Query: 3686 GQVVEQGTHNELIAKRGAYFAL 3751
G + EQGTH EL+ YF L
Sbjct: 1189 GSIKEQGTHQELLRNGDTYFKL 1210
Score = 365 bits (936), Expect = 6e-99
Identities = 209/595 (35%), Positives = 332/595 (55%), Gaps = 4/595 (0%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+S+ ++++ + + + + +G + S G P+ SII G L T+F D N
Sbjct: 636 VSLLKIFKLSKS-EWPFVVLGTLASALNGSVHPVFSIIFGK-------LVTMFEDKNKAT 687
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
++ A V+ YL G+F + +A E L+ R R F +++
Sbjct: 688 LKQDAELYSMMLVVLGIVALVTYLMQGLF---YGRAE------ENLAMRLRHSAFKAMLY 738
Query: 401 QEIAWYD--KNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLT 574
Q++AWYD +N +G L+ L ++ +++ ++G+ Q ++ ++F Y W +T
Sbjct: 739 QDMAWYDDKENNTGALTTTLAVDVAQIQGAATSRLGIVTQDVSNMSLSILISFIYGWEMT 798
Query: 575 LIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECK 754
L+++S +P + + G+ AG IA E + +IRTV++ + +
Sbjct: 799 LLILSFAPVLAVTGMIQTAAMAGFANRDKQALKRAGKIATEAVENIRTVVSLTRERAFEQ 858
Query: 755 RYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVF 934
YE+ L+ + +K++ + G A ++ ++ F G + +GR+ + VF
Sbjct: 859 MYEETLQTQHRNALKRAHITGCCYAVSHAFVHFAHAAGFRFGAYLIQAGRMMPEGMFIVF 918
Query: 935 FSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVN 1114
++ G+MA+G+ A A+ L+ ++ P I++ S G+ P G +
Sbjct: 919 TAIAYGAMAIGETLVWAPEYSKAKAGASHLFALLKNKPTINSCSQSGEKPDTCEGNLEFR 978
Query: 1115 KVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDD 1294
+V F YP R +V +L+ +SL + G+TVA VGSSGCGKST +QLLQRFY+P GQ+L+D
Sbjct: 979 EVSFVYPCRPEVPVLQNMSLSIEKGKTVAFVGSSGCGKSTCVQLLQRFYDPMKGQVLLDG 1038
Query: 1295 IPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSD--VSDEDIARALKEANAADFI 1468
+ +++ N+++LR +VSQEP LFN SI +NI YG + V E+I AN FI
Sbjct: 1039 VDVKELNVQWLRSQTAIVSQEPVLFNCSIAENIAYGDNSRMVPLEEIKEVADAANIHSFI 1098
Query: 1469 KTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSAL 1648
+ P NTLVG RGVQ+SGGQKQR+AIARAL+R PKILLLDEATSALD ESE +VQ AL
Sbjct: 1099 EGLPRKYNTLVGLRGVQLSGGQKQRLAIARALLRKPKILLLDEATSALDNESEKVVQQAL 1158
Query: 1649 ENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHA 1813
+ A RG+T +V+AHRLST++NAD I+V++ G + E GTH+ L+ Y +LV A
Sbjct: 1159 DKARRGKTCLVVAHRLSTIQNADMIVVLQNGSIKEQGTHQELLRNGDTYFKLVAA 1213
Score = 361 bits (926), Expect = 9e-98
Identities = 207/505 (40%), Positives = 295/505 (57%), Gaps = 2/505 (0%)
Frame = +2
Query: 2255 QCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYR 2434
Q S + + A R T RIR + + ++L QD ++FD + TR+ D + I +
Sbjct: 84 QISFWVITAARQTTRIRKQFFHSILAQDISWFDGSDIC--ELNTRMTGDINKLCDGIGDK 141
Query: 2435 LGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMEN 2614
+ +F I+ GL I+ W+++ +V++ P + AL + + +
Sbjct: 142 IPLMFQNISGFSIGLVISLIKSWKLSLVVLSTSPLIMASSALCSRMIISLTSKELDAYSK 201
Query: 2615 AGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFT 2794
AG A EA+ +I+TV A Q K + HL I +A L+ G
Sbjct: 202 AGAVAEEALSSIQTVTAFGAQEKEIQRYTQHLKDAKDAGIKRATASKLSLGAVYFFMNGA 261
Query: 2795 YAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFN 2974
Y AF +G LIF +L V F++ S IG A + + A AA IF
Sbjct: 262 YGLAFWYGTSLIFGGEPGYTIGTILAVFFSVIHSSYCIGSVAPHLETFTVARGAAFNIFQ 321
Query: 2975 MLEEEPRIDGMTSSGTYPQ-LSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVG 3151
+++++P ID +++G P+ + G ++ V F YP RP+ +L+GLN+ +K G+T+ALVG
Sbjct: 322 VIDKKPNIDNFSTAGFVPECIEGNIEFKNVSFSYPSRPSAKVLKGLNLKIKAGETVALVG 381
Query: 3152 PSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIREN 3331
PSG GKST + LL+RLYDP +G +TVD ND+R N +H R+ I +V QEP+LF T+I N
Sbjct: 382 PSGSGKSTTVQLLQRLYDPEDGCITVDENDIRAQNVRHYREQIGVVRQEPVLFGTTIGNN 441
Query: 3332 IVYGLQP-GEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARA 3508
I +G + GE +++E A +AN + FI P + T VGEKG Q+SGGQKQRIAIARA
Sbjct: 442 IKFGREGVGE---KEMEQAAREANAYDFIMAFPKKFNTLVGEKGAQMSGGQKQRIAIARA 498
Query: 3509 LIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNG 3688
L+RNPKIL+LDEATSALDTESE VQ AL+ A+K RT IVVAHRLSTI A I+ +K+G
Sbjct: 499 LVRNPKILILDEATSALDTESESLVQTALEKASKGRTTIVVAHRLSTIRGADLIVTMKDG 558
Query: 3689 QVVEQGTHNELIAKRGAYFALTQKQ 3763
VVE+GTH EL+AK+G Y++L Q
Sbjct: 559 MVVEKGTHAELMAKQGLYYSLAMAQ 583
>gi|17569909|ref|NP_509812.1| P-GlycoProtein related (pgp-7)
[Caenorhabditis elegans]
Length = 1269
Score = 888 bits (2294), Expect = 0.0
Identities = 498/1246 (39%), Positives = 729/1246 (57%), Gaps = 10/1246 (0%)
Frame = +2
Query: 56 LYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAA 235
+++ TS ++ + +G+ S TG+ P +S +G +Q VT+ + ++
Sbjct: 31 IFKCTSCFEKFLFLIGVFFSLVTGLCQPFVSYTLGETAQVLVTITNAINNKTIDPADLKK 90
Query: 236 ARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAW 415
A ++ + Q L + GC F +Q + + + + R R+Q+ ++R++ +
Sbjct: 91 AYEQYERGMYQVVLYFFLCGCAYFTFASIQHAIMKYVGDNTTYRVRKQYISRLLRKDAEY 150
Query: 416 YDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLS 595
+D ++G LS L DNLER RE +K+ L F ++ F+ G A+AF DW L + S
Sbjct: 151 FDNVSTGHLSTVLNDNLERFREVFNEKIALIFALLTDFVVGTALAFYTDWRLASYGIFFS 210
Query: 596 PFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALE 775
+ G YA AG IA + L + +TV + NGQ E +RY + L+
Sbjct: 211 LGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQNTEIERYTEELK 270
Query: 776 HGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGS 955
G+K GI ++ + + + + +VG N +YSG LE V+ +F +M G+
Sbjct: 271 AGEKYGIHRALMYSISRGFTYFFCNSLNTVILYVGANMIYSGSLEPAVVVRIFHYMMFGA 330
Query: 956 MALGQAGQQFATIGTALGAAASLYEVI---DRIPEIDAYSTEGQTPSKISGRISVNKVEF 1126
L +A + + A+ + A + E++ D + E D T+ +++G IS V+F
Sbjct: 331 FCLSEALPHISRLAGAISSTAPIAEMLIKEDNVIEKD--ETDYDVEVEVNGNISFKNVKF 388
Query: 1127 TYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIE 1306
+YPTR D ++LKG+S D Q G+ +ALVG+SG GKST++QLL +YN D+G I ID + +
Sbjct: 389 SYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLN 448
Query: 1307 DFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEG 1486
D NIK LR+++GVVSQEP LFNT+IE+NIR+G +VS +I AL++ANA DF+ +FP+G
Sbjct: 449 DMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKG 508
Query: 1487 LNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRG 1666
+ T+VG+RG Q+SGGQKQRIAIAR LVRNPKILLLDEATSALD ESE +VQ ALENAS+G
Sbjct: 509 IKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQG 568
Query: 1667 RTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVDDKPK 1846
RTTIV+AHRLST+RNA KIIVM+ G+++EVG H+ LI ++G+Y++LV AQ+ DD
Sbjct: 569 RTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLESHDD--- 625
Query: 1847 KKEAERRMSRQTSQRKGSV-NFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXGAVK 2023
+E +RQ SQ + ++ Q S GA K
Sbjct: 626 HEELPPLAARQLSQELSPLHSYAIQRS-------TSNDAGVHDDDMERILDELSKEGAKK 678
Query: 2024 ANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHFW 2203
+NL +I++ RP++ + IQG P + + F+ D M H W
Sbjct: 679 SNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGED-MLYYSHLW 737
Query: 2204 ALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRIT 2383
AL F+ LA + ++ Q FG +E+L+ R+R K + ++L ++D P HS R++
Sbjct: 738 ALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLS 797
Query: 2384 TRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALM 2563
RL TD+ N+K+A+D RLG + + ++ + A Y W+M V+ FP + + +
Sbjct: 798 NRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLIFFPLLYLAEYCY 857
Query: 2564 MKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKA 2743
S D EN+ +TA+EA+EN+RTV+AL L+ K+ ++ HL H +A
Sbjct: 858 DAATETSIQEDTIAFENSNRTAIEALENMRTVRALNLEDKIMSLISEHLQKIHKSYFKRA 917
Query: 2744 IIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAAS 2923
II+G G + S F Y+ +F+FG +L K V P + +L +S + G AA+
Sbjct: 918 IIQGAANGLSLSCYLFVYSVSFKFGTYLALRKEV--APMDTYLILETLSMTANMAGSAAA 975
Query: 2924 YFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVFFRYPERPAVPILQ 3103
Y P+Y KA AAGLIF++ + +S G GE+ V F Y +RP IL
Sbjct: 976 YLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILN 1035
Query: 3104 GLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVT------VDNNDLRQMNPKH 3265
G+N+ V PG+TLALVGPSGCGKST+ISLLER Y ++G V +D+ ++ +N H
Sbjct: 1036 GVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVVSIDAHKIDSENVEDINLNH 1095
Query: 3266 LRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETR 3445
LR ++ALVSQEP LF+ SIREN++YGL ++E A AN F+ + P G +T
Sbjct: 1096 LRSNLALVSQEPTLFNCSIRENLLYGL-TRSVPQLELEKALQTANAFNFVFQFPQGLDTI 1154
Query: 3446 VGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCI 3625
VGE+G QLSGGQKQRIAIARA++RNPK+LLLDEATSALD++SEK VQ ALD A++ + +
Sbjct: 1155 VGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTV 1214
Query: 3626 VVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQ 3763
VVAHRL T+VNA I V+KNG+V EQGTH EL+ KR Y+ L QKQ
Sbjct: 1215 VVAHRLLTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 1260
>gi|18496816|gb|AAL74249.1| ABC transporter AbcB2 [Dictyostelium
discoideum]
Length = 1407
Score = 880 bits (2275), Expect = 0.0
Identities = 495/1302 (38%), Positives = 737/1302 (56%), Gaps = 61/1302 (4%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+ F L+R+ D L++ +G I + A GV +P +SI+ G + +F DPN
Sbjct: 123 VPFFSLFRFAKPFDILLMIIGTIGALANGVSMPAISIVFGRLMNSFSPEN--LADPNFDL 180
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
E V N + ++Y+GCG+F +++ + +M+ E+ + R R+ + ++++
Sbjct: 181 VET----------VTSNAMYFIYIGCGVFVCSYVEVAFWMLAGERQAVRCRKAYLKAILK 230
Query: 401 QEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFT-------- 556
QEI WYD S LS ++ + +E G+K+G + FI GF V F
Sbjct: 231 QEIGWYDVTKSSELSTRISSDTLLFQEAIGEKIGNFLHHTSTFICGFIVGFVNGKNYNYY 290
Query: 557 --YDWLLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAF 730
+ W LTL++ +L+P + G F YA AGG+AEE + SIRTV F
Sbjct: 291 LFFCWQLTLVIFALTPLIAAAGAFMTKMMADLTKKGQDAYAKAGGVAEEKIGSIRTVSTF 350
Query: 731 NGQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRL- 907
+G+ +E KRY + L+ G KK + G G+ F++++ +Y L+FW G + +
Sbjct: 351 SGEPFEVKRYTERLKEALDIGTKKGIMNGIGIGLVFLVLFGTYSLSFWYGGKLIVDRKWN 410
Query: 908 -------ESGTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYS 1066
+ G VLTVFFSV+MG+MALGQA A+ GAA +YEV+DR +ID +S
Sbjct: 411 PVPDRPWQGGDVLTVFFSVIMGAMALGQASPNVASFANGRGAAFKIYEVVDRNSKIDPFS 470
Query: 1067 TEGQTPSK-ISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQ 1243
TEG++ + + G I + F+YP+R DVKI +L + G TVALVG SG GKS++I
Sbjct: 471 TEGRSIEETVQGNIEYRNIGFSYPSRPDVKIFNNFNLTIKKGTTVALVGDSGGGKSSVIG 530
Query: 1244 LLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDE 1423
LL+RFY+PD G++ +D I++ NI LR+ +G+VSQEP LF SI +NIRYG + + +
Sbjct: 531 LLERFYDPDEGEVYLDGTNIKEINIHSLRRNIGLVSQEPVLFANSIAENIRYGNENATMD 590
Query: 1424 DIARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEAT 1603
I A K ANA DFI PEG +T VG++GVQMSGGQKQRIAIARA++++PKILLLDEAT
Sbjct: 591 QIIEACKTANAHDFISALPEGYDTQVGEKGVQMSGGQKQRIAIARAMIKDPKILLLDEAT 650
Query: 1604 SALDAESESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQ 1783
SALD+++E +VQ ++E GRTTIVIAHRLST+++AD+I V+K G ++E+GTH L
Sbjct: 651 SALDSQNELLVQQSIEKLMIGRTTIVIAHRLSTIQDADQIAVVKGGAIVEIGTHPELYAL 710
Query: 1784 KGLYHELVHAQVFADVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXX 1963
G+Y +LV+ Q DD KKK ++ S+++S+ + + N +D
Sbjct: 711 NGVYTQLVNRQQKGG-DDGDKKK---KKKSKESSKDESNNNIGPSSISIDKSIQSIGADS 766
Query: 1964 XXXXXXXXXXXXXXXXGAVKAN--------LFKILRYARPEWIYXXXXXXXXLIQGAVMP 2119
K + +IL+ +R +W + + GA+MP
Sbjct: 767 LETSTIGLVNDNDNKKKKKKEKKPQEKSVPIGRILKLSRGDWPHFLIGLVGATLNGAIMP 826
Query: 2120 AFSLFFSQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMR 2299
FS+ FS+I+ +F D D++ + AL F++LA V + Q F E+LT
Sbjct: 827 VFSIIFSEILGIFQEQDTDELTRRSRNMALWFILLAVVAALANFIQIYCFTFIGEKLTFN 886
Query: 2300 IRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGL 2479
+R + +++RQD +FD+ ++S GR+T LAT+A ++ RLG + I ++ GL
Sbjct: 887 LRRLSFESIMRQDIGWFDLTENSTGRLTANLATEATLVQGMTSQRLGLLIQNIVTIVAGL 946
Query: 2480 GIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTV 2659
IAF GW++ +V+A P + + M + G + + G+ A EAI IRTV
Sbjct: 947 VIAFVSGWKLTLVVLACVPVIGFAGKVEMDFFQGFSQKGKEAYAECGQVASEAIGGIRTV 1006
Query: 2660 QALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFD- 2836
+ T + K+ F L P + K+ + GL++GF+ FF Y + +G L+
Sbjct: 1007 SSFTCENKILEKFRQCLQKPIQMSFRKSNVSGLSFGFSQCTLFFIYTLTYWYGGKLVDSG 1066
Query: 2837 ----KNVLMEP----------------------------ENVLRVLFAISFSFGTIGFAA 2920
K +E ++RV FAI S +G +
Sbjct: 1067 EWPAKESTLETYCYNGEYANIGYTDEATCIKSFTTTEGFSMMMRVFFAIIMSAMGVGQSM 1126
Query: 2921 SYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSG-TYPQLSGEVKLNKVFFRYPERPAVPI 3097
++ P+ KA AA IF++++ ID + G T P+ G+++ + F YP RP +
Sbjct: 1127 AFMPDLGKAKLAAVAIFSLIDRVSEIDPFENKGQTLPEFKGDIEFKDIKFSYPSRPNKAV 1186
Query: 3098 LQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKH 3277
QG N+ + G+ +ALVG SG GKS+VISLLER Y+P +G++T+D +++ +N LR +
Sbjct: 1187 FQGFNLVIPHGKKVALVGNSGGGKSSVISLLERFYNPSQGSITIDGVNIKDLNLNWLRGN 1246
Query: 3278 IALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEK 3457
+ LV QEP LF +I ENI+YG + T +++ A AN H FI+ LPD Y T++G+K
Sbjct: 1247 MGLVGQEPFLFSGTIFENIIYG--KPDATMDEVVEAAKAANAHTFIESLPDAYHTQLGDK 1304
Query: 3458 GTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAH 3637
TQLSGGQKQR+AIARA+IRNPK+LLLDEATSALDT SEK VQVALD +K RT IV+AH
Sbjct: 1305 FTQLSGGQKQRVAIARAIIRNPKVLLLDEATSALDTVSEKVVQVALDNVSKGRTSIVIAH 1364
Query: 3638 RLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQ 3763
RLST+++A I+VVK G+VVE GTH L+A+ G Y L +Q
Sbjct: 1365 RLSTVIDADLIVVVKEGKVVELGTHETLLAENGFYAELVSRQ 1406
Score = 381 bits (978), Expect = e-104
Identities = 222/611 (36%), Positives = 339/611 (55%), Gaps = 37/611 (6%)
Frame = +2
Query: 98 VGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHEVIQNCL 277
+G++ + G +P+ SII + LG IF + ++ E + L
Sbjct: 813 IGLVGATLNGAIMPVFSIIFSEI------LG-IFQEQDTD---------ELTRRSRNMAL 856
Query: 278 KYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYD--KNTSGTLSNK 451
++ L A F+Q CF I EKL+ RR F S+MRQ+I W+D +N++G L+
Sbjct: 857 WFILLAVVAALANFIQIYCFTFIGEKLTFNLRRLSFESIMRQDIGWFDLTENSTGRLTAN 916
Query: 452 LFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXXX 631
L V+ T ++GL Q + + G +AF W LTL++++ P + G
Sbjct: 917 LATEATLVQGMTSQRLGLLIQNIVTIVAGLVIAFVSGWKLTLVVLACVPVIGFAGKVEMD 976
Query: 632 XXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFL 811
YA G +A E + IRTV +F + +++ L+ + +KS +
Sbjct: 977 FFQGFSQKGKEAYAECGQVASEAIGGIRTVSSFTCENKILEKFRQCLQKPIQMSFRKSNV 1036
Query: 812 IGAGLASFFVIIYASYCLAFWVGTNFVYSGR----------------------------L 907
G ++ Y L +W G V SG +
Sbjct: 1037 SGLSFGFSQCTLFFIYTLTYWYGGKLVDSGEWPAKESTLETYCYNGEYANIGYTDEATCI 1096
Query: 908 ESGT-------VLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYS 1066
+S T ++ VFF+++M +M +GQ+ +G A AA +++ +IDR+ EID +
Sbjct: 1097 KSFTTTEGFSMMMRVFFAIIMSAMGVGQSMAFMPDLGKAKLAAVAIFSLIDRVSEIDPFE 1156
Query: 1067 TEGQTPSKISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQL 1246
+GQT + G I ++F+YP+R + + +G +L G+ VALVG+SG GKS++I L
Sbjct: 1157 NKGQTLPEFKGDIEFKDIKFSYPSRPNKAVFQGFNLVIPHGKKVALVGNSGGGKSSVISL 1216
Query: 1247 LQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDED 1426
L+RFYNP G I ID + I+D N+ +LR +G+V QEP LF+ +I +NI YG+ D + ++
Sbjct: 1217 LERFYNPSQGSITIDGVNIKDLNLNWLRGNMGLVGQEPFLFSGTIFENIIYGKPDATMDE 1276
Query: 1427 IARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATS 1606
+ A K ANA FI++ P+ +T +GD+ Q+SGGQKQR+AIARA++RNPK+LLLDEATS
Sbjct: 1277 VVEAAKAANAHTFIESLPDAYHTQLGDKFTQLSGGQKQRVAIARAIIRNPKVLLLDEATS 1336
Query: 1607 ALDAESESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQK 1786
ALD SE +VQ AL+N S+GRT+IVIAHRLSTV +AD I+V+K G+V+E+GTHETL+ +
Sbjct: 1337 ALDTVSEKVVQVALDNVSKGRTSIVIAHRLSTVIDADLIVVVKEGKVVELGTHETLLAEN 1396
Query: 1787 GLYHELVHAQV 1819
G Y ELV Q+
Sbjct: 1397 GFYAELVSRQM 1407
Score = 336 bits (862), Expect = 2e-90
Identities = 217/608 (35%), Positives = 325/608 (52%), Gaps = 24/608 (3%)
Frame = +2
Query: 2033 FKILRYARP-EWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFS-----NPDRDQMKKDG 2194
F + R+A+P + + L G MPA S+ F +++N FS +P+ D ++
Sbjct: 126 FSLFRFAKPFDILLMIIGTIGALANGVSMPAISIVFGRLMNSFSPENLADPNFDLVETVT 185
Query: 2195 HFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPG 2374
A+ F+ + + + + +A ER +R R + +L+Q+ ++D+ K S
Sbjct: 186 SN-AMYFIYIGCGVFVCSYVEVAFWMLAGERQAVRCRKAYLKAILKQEIGWYDVTKSS-- 242
Query: 2375 RITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYG----------WQMAFLVM 2524
++TR+++D + AI ++G+ + ++ G + F G WQ+ ++
Sbjct: 243 ELSTRISSDTLLFQEAIGEKIGNFLHHTSTFICGFIVGFVNGKNYNYYLFFCWQLTLVIF 302
Query: 2525 AIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCS 2704
A+ P +A A M K AG A E I +IRTV + + +
Sbjct: 303 ALTPLIAAAGAFMTKMMADLTKKGQDAYAKAGGVAEEKIGSIRTVSTFSGEPFEVKRYTE 362
Query: 2705 HLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPE------NV 2866
L K I+ G+ G + F TY+ +F +G LI D+ P+ +V
Sbjct: 363 RLKEALDIGTKKGIMNGIGIGLVFLVLFGTYSLSFWYGGKLIVDRKWNPVPDRPWQGGDV 422
Query: 2867 LRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ--LSG 3040
L V F++ +G A+ + AA I+ +++ +ID ++ G + + G
Sbjct: 423 LTVFFSVIMGAMALGQASPNVASFANGRGAAFKIYEVVDRNSKIDPFSTEGRSIEETVQG 482
Query: 3041 EVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGA 3220
++ + F YP RP V I N+ +K G T+ALVG SG GKS+VI LLER YDP EG
Sbjct: 483 NIEYRNIGFSYPSRPDVKIFNNFNLTIKKGTTVALVGDSGGGKSSVIGLLERFYDPDEGE 542
Query: 3221 VTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKAN 3400
V +D +++++N LR++I LVSQEP+LF SI ENI YG + T +QI AC AN
Sbjct: 543 VYLDGTNIKEINIHSLRRNIGLVSQEPVLFANSIAENIRYGNENA--TMDQIIEACKTAN 600
Query: 3401 IHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQ 3580
H FI LP+GY+T+VGEKG Q+SGGQKQRIAIARA+I++PKILLLDEATSALD+++E
Sbjct: 601 AHDFISALPEGYDTQVGEKGVQMSGGQKQRIAIARAMIKDPKILLLDEATSALDSQNELL 660
Query: 3581 VQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQK 3760
VQ +++ RT IV+AHRLSTI +A I VVK G +VE GTH EL A G Y L +
Sbjct: 661 VQQSIEKLMIGRTTIVIAHRLSTIQDADQIAVVKGGAIVEIGTHPELYALNGVYTQLVNR 720
Query: 3761 QSSNQSGG 3784
Q Q GG
Sbjct: 721 Q---QKGG 725
>gi|40644167|emb|CAC86593.1| sister of P-glycoprotein [Platichthys
flesus]
gi|40644169|emb|CAC86594.1| sister of P-glycoprotein [Platichthys
flesus]
Length = 1356
Score = 877 bits (2265), Expect = 0.0
Identities = 508/1296 (39%), Positives = 726/1296 (55%), Gaps = 59/1296 (4%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLD----- 205
+ FQL+R+++ + +M+ +G + + G PLM ++ G ++ F+ +
Sbjct: 55 VGFFQLFRFSTCREVVMMVIGSVCAVLHGSAQPLMLLVFGLLTDTFIEYDIELNELRDVR 114
Query: 206 ---PNSTASEKAAARA---------------------------EFSHEVIQNCLKYVYLG 295
N+T K+ A + +E+ + L YV +
Sbjct: 115 KECVNNTIQWKSDYTAALNQSDWSLNSTWEVLVPLKNLTCGVLDIEYEMTKFALYYVGIA 174
Query: 296 CGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYDKNTSGTLSNKLFDNLERV 475
+F G+LQ S ++ + R+ +F VMR EI W+D + G L+ ++ D++ ++
Sbjct: 175 FAVFLLGYLQISLWVQAAARQVQIVRKMYFSKVMRMEIGWFDCTSVGELNTRMSDDINKI 234
Query: 476 REGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXXXXXXXXXXX 655
+ D+V + Q F+ GF + F W LTL++++ SP + I F
Sbjct: 235 NDAIADQVAIFLQRFTTFVCGFCIGFVKGWKLTLVIVAASPLIGIGAGFMALFVAKLTGR 294
Query: 656 XXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFLIGAGLASF 835
YA AG +A+EVL+SIRTV AF G+ E +RY+ L ++ GI+K ++G
Sbjct: 295 ELQAYAKAGAVADEVLSSIRTVSAFGGELKEVQRYDRNLISAQRWGIRKGMIMGFFTGYM 354
Query: 836 FVIIYASYCLAFWVGTNFVY-SGRLESGTVLTVFFSVMMGSMALGQAGQQFATIGTALGA 1012
++II+ Y LAFW G+ V + GT+L VFF V++ +M LGQA GA
Sbjct: 355 WLIIFLCYALAFWYGSGLVLDTAEYTPGTLLQVFFGVLIAAMNLGQASPCLEAFAAGRGA 414
Query: 1013 AASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQ 1192
A ++E IDR PEID S G ++ G I + V F YP+R +VK L +S+ + G+
Sbjct: 415 ATIIFETIDREPEIDCLSEAGYKLDRVKGDIEFHNVTFHYPSRPEVKTLDQLSVAVKSGE 474
Query: 1193 TVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFN 1372
T A VG SG GKST IQL QRFY+P G + +D I NI++LR L+G+V QEP LF
Sbjct: 475 TTAFVGPSGAGKSTAIQLFQRFYDPKEGMVTLDGHDIRGLNIQWLRSLIGIVEQEPVLFA 534
Query: 1373 TSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAI 1552
T+I +NI YGR VS EDI A KEANA FI+ P+ NT+VG+ G QMSGGQKQRIAI
Sbjct: 535 TTIAENICYGRPGVSMEDIVAAAKEANAYHFIQDLPQKFNTMVGEGGGQMSGGQKQRIAI 594
Query: 1553 ARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVM 1732
ARALVRNP+ILLLD ATSALD ESE+IVQ AL+ GRTTI IAHRLST++NAD I+
Sbjct: 595 ARALVRNPRILLLDMATSALDNESEAIVQEALDKVRLGRTTISIAHRLSTIKNADVIVGF 654
Query: 1733 KAGQVMEVGTHETLIEQKGLYHELVHAQVFAD--VDDKPKK---KEAE---RRMSRQTSQ 1888
+ G+ +E G H L+E+KG+Y LV Q D +++K ++ KE E + +SR S
Sbjct: 655 EHGRAVEKGKHGELLERKGVYFMLVTLQSQGDKALNEKARQLAEKEEEPVKQNLSRAGSY 714
Query: 1889 RKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXGAVKANL------------ 2032
R + Q S+ KA++
Sbjct: 715 RASLRSSIRQRSRSQLSNLIPDSSASMVGELGPRTYTFSQPDTSKADIPEEEEEEVVEPA 774
Query: 2033 --FKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHFWA 2206
+IL+Y PEW Y I G V P +SL FSQI+ FS D +K+
Sbjct: 775 PVARILKYNIPEWPYMLFGSIGAAINGGVNPVYSLLFSQILATFSVTDPVAQRKEIDSIC 834
Query: 2207 LMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITT 2386
+ F+++ V + + Q F + E LT R+R + +L Q+ +FD ++SPG +TT
Sbjct: 835 MFFVMVGVVSSFTQMLQGYAFSKSGELLTRRLRRLGFHAMLGQEIGWFDDHRNSPGALTT 894
Query: 2387 RLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMM 2566
RLATDA ++ A ++G I N++ ++G + ++FY+ W++ L++ PF+A+
Sbjct: 895 RLATDASQVQGATGSQIGMIVNSLTNIGVAVLMSFYFSWKLTMLILCFLPFIALSGGFQA 954
Query: 2567 KYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAI 2746
K G A D + ME AG+ + EA+ NIRT+ L + +++ + LD P + KA
Sbjct: 955 KMLTGFAKQDKEAMEAAGRISGEALNNIRTIAGLGKEQSFVDMYEAQLDGPFQAALKKAH 1014
Query: 2747 IRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASY 2926
+ G YGFA + F T +A++RFG +L+ + + V RV+ AI S +G A+SY
Sbjct: 1015 VYGACYGFAQCVVFLTNSASYRFGGYLVRQEGLHFSL--VFRVISAIVTSGTALGKASSY 1072
Query: 2927 FPEYIKATFAAGLIFNMLEEEPRIDGMTSSGT-YPQLSGEVKLNKVFFRYPERPAVPILQ 3103
P+Y KA +A F +L+ P+I + G + G ++ F YP RP + +L
Sbjct: 1073 TPDYAKAKISAARFFKLLDRVPQISVYSDKGDKWDNFQGNLEFIDCKFTYPTRPDIQVLN 1132
Query: 3104 GLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIA 3283
GLNV V+PGQTLA VG SGCGKST + LLER YDP G V +D +D +N LR I
Sbjct: 1133 GLNVSVRPGQTLAFVGSSGCGKSTSVQLLERFYDPDHGRVLIDGHDSTGVNVPFLRSKIG 1192
Query: 3284 LVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGT 3463
+VSQEPILFD SI +NI YG E + + +A KA +H F+ LP+ Y+T VG +G+
Sbjct: 1193 IVSQEPILFDCSIADNIKYGDNSREISLNDVMSAAKKAQLHNFVMALPEKYDTNVGAQGS 1252
Query: 3464 QLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRL 3643
QLS GQKQRIAIARA+IR+PKILLLDEATSALDTESEK VQ ALD A + RTCIV+AHRL
Sbjct: 1253 QLSRGQKQRIAIARAIIRDPKILLLDEATSALDTESEKIVQEALDKAREGRTCIVIAHRL 1312
Query: 3644 STIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFAL 3751
STI N+ I V+ G V+E+GTHN+L+ +GAY+ L
Sbjct: 1313 STIQNSDIIAVMSRGYVIEKGTHNQLMLLKGAYYKL 1348
Score = 365 bits (936), Expect = 6e-99
Identities = 201/521 (38%), Positives = 300/521 (57%), Gaps = 4/521 (0%)
Frame = +2
Query: 257 EVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYD--KNT 430
E+ C+ +V +G LQ F E L+ R RR FH+++ QEI W+D +N+
Sbjct: 829 EIDSICMFFVMVGVVSSFTQMLQGYAFSKSGELLTRRLRRLGFHAMLGQEIGWFDDHRNS 888
Query: 431 SGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMI 610
G L+ +L + +V+ TG ++G+ + ++F + W LT++++ PF+ +
Sbjct: 889 PGALTTRLATDASQVQGATGSQIGMIVNSLTNIGVAVLMSFYFSWKLTMLILCFLPFIAL 948
Query: 611 CGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKT 790
G F AG I+ E L +IRT+ ++ YE L+ +
Sbjct: 949 SGGFQAKMLTGFAKQDKEAMEAAGRISGEALNNIRTIAGLGKEQSFVDMYEAQLDGPFQA 1008
Query: 791 GIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQ 970
+KK+ + GA +++ + ++ G V L V V +++ ALG+
Sbjct: 1009 ALKKAHVYGACYGFAQCVVFLTNSASYRFGGYLVRQEGLHFSLVFRVISAIVTSGTALGK 1068
Query: 971 AGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADV 1150
A A +AA ++++DR+P+I YS +G G + +FTYPTR D+
Sbjct: 1069 ASSYTPDYAKAKISAARFFKLLDRVPQISVYSDKGDKWDNFQGNLEFIDCKFTYPTRPDI 1128
Query: 1151 KILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLR 1330
++L G+++ +PGQT+A VGSSGCGKST +QLL+RFY+PD G++LID N+ +LR
Sbjct: 1129 QVLNGLNVSVRPGQTLAFVGSSGCGKSTSVQLLERFYDPDHGRVLIDGHDSTGVNVPFLR 1188
Query: 1331 QLVGVVSQEPNLFNTSIEQNIRYGRS--DVSDEDIARALKEANAADFIKTFPEGLNTLVG 1504
+G+VSQEP LF+ SI NI+YG + ++S D+ A K+A +F+ PE +T VG
Sbjct: 1189 SKIGIVSQEPILFDCSIADNIKYGDNSREISLNDVMSAAKKAQLHNFVMALPEKYDTNVG 1248
Query: 1505 DRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVI 1684
+G Q+S GQKQRIAIARA++R+PKILLLDEATSALD ESE IVQ AL+ A GRT IVI
Sbjct: 1249 AQGSQLSRGQKQRIAIARAIIRDPKILLLDEATSALDTESEKIVQEALDKAREGRTCIVI 1308
Query: 1685 AHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELV 1807
AHRLST++N+D I VM G V+E GTH L+ KG Y++LV
Sbjct: 1309 AHRLSTIQNSDIIAVMSRGYVIEKGTHNQLMLLKGAYYKLV 1349
Score = 337 bits (865), Expect = 1e-90
Identities = 205/523 (39%), Positives = 289/523 (55%), Gaps = 1/523 (0%)
Frame = +2
Query: 2201 WALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRI 2380
+AL ++ +A Q SL+ AA R +R + V+R + +FD S G +
Sbjct: 166 FALYYVGIAFAVFLLGYLQISLWVQAAARQVQIVRKMYFSKVMRMEIGWFDCT--SVGEL 223
Query: 2381 TTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQAL 2560
TR++ D I AI ++ + G I F GW++ +++A P + +G
Sbjct: 224 NTRMSDDINKINDAIADQVAIFLQRFTTFVCGFCIGFVKGWKLTLVIVAASPLIGIGAGF 283
Query: 2561 MMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISK 2740
M + + + AG A E + +IRTV A + K + +L + I K
Sbjct: 284 MALFVAKLTGRELQAYAKAGAVADEVLSSIRTVSAFGGELKEVQRYDRNLISAQRWGIRK 343
Query: 2741 AIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAA 2920
+I G G+ I F YA AF +G L+ D P +L+V F + + +G A+
Sbjct: 344 GMIMGFFTGYMWLIIFLCYALAFWYGSGLVLD-TAEYTPGTLLQVFFGVLIAAMNLGQAS 402
Query: 2921 SYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSG-TYPQLSGEVKLNKVFFRYPERPAVPI 3097
+ AA +IF ++ EP ID ++ +G ++ G+++ + V F YP RP V
Sbjct: 403 PCLEAFAAGRGAATIIFETIDREPEIDCLSEAGYKLDRVKGDIEFHNVTFHYPSRPEVKT 462
Query: 3098 LQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKH 3277
L L+V VK G+T A VGPSG GKST I L +R YDP EG VT+D +D+R +N + LR
Sbjct: 463 LDQLSVAVKSGETTAFVGPSGAGKSTAIQLFQRFYDPKEGMVTLDGHDIRGLNIQWLRSL 522
Query: 3278 IALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEK 3457
I +V QEP+LF T+I ENI YG +PG + E I A +AN + FI +LP + T VGE
Sbjct: 523 IGIVEQEPVLFATTIAENICYG-RPG-VSMEDIVAAAKEANAYHFIQDLPQKFNTMVGEG 580
Query: 3458 GTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAH 3637
G Q+SGGQKQRIAIARAL+RNP+ILLLD ATSALD ESE VQ ALD RT I +AH
Sbjct: 581 GGQMSGGQKQRIAIARALVRNPRILLLDMATSALDNESEAIVQEALDKVRLGRTTISIAH 640
Query: 3638 RLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQS 3766
RLSTI NA I+ ++G+ VE+G H EL+ ++G YF L QS
Sbjct: 641 RLSTIKNADVIVGFEHGRAVEKGKHGELLERKGVYFMLVTLQS 683
>gi|157873|gb|AAA16186.1| P-glycoprotein/multidrug resistance protein
Length = 1283
Score = 873 bits (2256), Expect = 0.0
Identities = 499/1265 (39%), Positives = 721/1265 (56%), Gaps = 21/1265 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+S FQL+RY + DR + +G++ + TG+ P S+I GN++ + + L + S
Sbjct: 44 VSYFQLFRYATKKDRALYVIGLLSAVGTGLTTPANSLIFGNLANDMIDLSGLLESGKSYR 103
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
++ A + +V Q L+ Y+G + +L +CF R +FF S++
Sbjct: 104 ADDAISTLLLD-KVRQFSLQNTYIGMIMLVCSYLSITCFNYAAHSQILTIRSKFFRSILH 162
Query: 401 QEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLI 580
Q++ WYD N SG +++++ ++L ++ +G +KV + + F+G +AF W L+L+
Sbjct: 163 QDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLV 222
Query: 581 MMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRY 760
++ P I YA A +AE L+ IRTV AF G+ E Y
Sbjct: 223 CLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAY 282
Query: 761 EDALEHGKKTGIKKSFLIGAGLAS-FFVIIYASYCLAFWVGTNFVYSGRLES---GTVLT 928
++ + K IK++ G G +F IYASY LAFW G V E+ GT++T
Sbjct: 283 KERVVAAKILNIKRNMFSGIGFGLLWFFFIYASYALAFWYGVGLVIESAYENYDAGTMIT 342
Query: 929 VFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRIS 1108
VFFSVMMGSM +G A G A G ++ +I++IPEI+ + ++ I
Sbjct: 343 VFFSVMMGSMNIGMAAPYIEAFGIAQGRLPKVFHIIEQIPEINPLMGRVKVNEPLT-TIE 401
Query: 1109 VNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILI 1288
+VEF YPTR +V IL ++L GQTVALVG SGCGKST IQL+QRFY+P AG +L
Sbjct: 402 FKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLF 461
Query: 1289 DDIPIEDFNIKYLRQL-VGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADF 1465
+ ++D +I +LR L +GVV QEP LF TSI +NIRYGR D + E+I A ANAA F
Sbjct: 462 NGTNLKDLDINWLRFLRIGVVGQEPILFATSIYENIRYGREDATREEIEAARAAANAAIF 521
Query: 1466 IKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSA 1645
IK P+G +TLVG+RG Q+SGGQKQRIAI RAL+R+P+ILLLDEATSALD SE+ VQ+A
Sbjct: 522 IKKLPKGYDTLVGERGAQLSGGQKQRIAIRRALIRDPEILLLDEATSALDTASEAKVQAA 581
Query: 1646 LENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQ--- 1816
LE S GRTTI++AHRLSTVR AD+I+V+ G+V+E GTH+ L+E K Y LV Q
Sbjct: 582 LEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLVTTQLGE 641
Query: 1817 -----------VFADVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXX 1963
++ + D K + +E + +S + + K ++ ++
Sbjct: 642 DDGSVLSPTGDIYKNFDIKDEDEEEIKVLSEDEDEDVMVTDEKNKKKKM----------- 690
Query: 1964 XXXXXXXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQ 2143
VK + ++++ +PEW+ +I G MP F++ F
Sbjct: 691 ----------KKVKDPNEVKP-MLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGS 739
Query: 2144 IINVFSNPDRDQ-MKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYR 2320
I+ + S D DQ ++++ + ++L FL+ V G + Q FG+A ERLT R+R ++
Sbjct: 740 ILQILSVKDNDQYVRENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFE 799
Query: 2321 NVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYG 2500
+LRQ+ +FD + G + RL+ DA ++ A R+G+I +I+++ G+ ++ YY
Sbjct: 800 AMLRQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIIQSISTLALGIALSMYYE 859
Query: 2501 WQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQT 2680
W + + +A PF+ + + AK MEN K A+E + NIRTV +L +
Sbjct: 860 WSLGLVALAFTPFILIAFYMQRTLMAKENMRPAKTMENCTKLAVEVVSNIRTVASLGREE 919
Query: 2681 KLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPE 2860
+ + L + RGL YG A S+ FF YAA +G + + + +L
Sbjct: 920 MFHQNYIGMLIPAVEISKRNTHFRGLVYGLARSLMFFAYAACMYYGTWCVIHRGILF--G 977
Query: 2861 NVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLS- 3037
+V +V A+ +I A ++ P K AA IF L +P I P S
Sbjct: 978 DVFKVSQAVIMGTASIANALAFAPNMQKGVSAAKTIFTFLRRQPSIVDRPGVSRDPWHSE 1037
Query: 3038 GEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEG 3217
G V+ +KV F YP R + +L+GL + V GQ +ALVGPSGCGKST I L++R YD EG
Sbjct: 1038 GYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEG 1097
Query: 3218 AVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKA 3397
A +D D+R ++ +LR + +VSQEPILFD +IRENI YG T ++I +AC K+
Sbjct: 1098 ATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARNVTDQEIISACKKS 1157
Query: 3398 NIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEK 3577
NIH+FI LP GY+TR+GEKG QLSGGQKQRIAIARALIRNPKI+LLDEATSALD ESEK
Sbjct: 1158 NIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESEK 1217
Query: 3578 QVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQ 3757
VQ ALDAA++ RT I +AHRLST+V++ I V +NG V E G H +L+A RG Y+ L +
Sbjct: 1218 VVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLLANRGLYYTLYK 1277
Query: 3758 KQSSN 3772
QS +
Sbjct: 1278 LQSGS 1282
Score = 315 bits (807), Expect = 5e-84
Identities = 213/611 (34%), Positives = 319/611 (51%), Gaps = 24/611 (3%)
Frame = +2
Query: 2021 KANLFKILRYA-RPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGH 2197
+ + F++ RYA + + + G PA SL F + N D + + G
Sbjct: 43 QVSYFQLFRYATKKDRALYVIGLLSAVGTGLTTPANSLIFGNLANDMI--DLSGLLESGK 100
Query: 2198 FW----ALMFLVLAAVQGTSM--------LFQCSL-----FGVAAERLTMRIRSKVYRNV 2326
+ A+ L+L V+ S+ + CS F AA + IRSK +R++
Sbjct: 101 SYRADDAISTLLLDKVRQFSLQNTYIGMIMLVCSYLSITCFNYAAHSQILTIRSKFFRSI 160
Query: 2327 LRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQ 2506
L QD ++D + G + +R+ D ++ + ++ + + + G L +AF GWQ
Sbjct: 161 LHQDMKWYDF--NQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQ 218
Query: 2507 MAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKL 2686
++ + + P + L+ A + A A A+ IRTV+A + K
Sbjct: 219 LSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKE 278
Query: 2687 YNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFF----TYAAAFRFGLFLIFDKNVL-M 2851
+ + A NI + + G+ +G + FF +YA AF +G+ L+ +
Sbjct: 279 VAAYKERVVAAKILNIKRNMFSGIGFGL---LWFFFIYASYALAFWYGVGLVIESAYENY 335
Query: 2852 EPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ 3031
+ ++ V F++ IG AA Y + A +F+++E+ P I+ + +
Sbjct: 336 DAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAQGRLPKVFHIIEQIPEINPLMGRVKVNE 395
Query: 3032 LSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPL 3211
++ +V F+YP RP V IL LN+ + GQT+ALVGPSGCGKST I L++R YDP
Sbjct: 396 PLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQ 455
Query: 3212 EGAVTVDNNDLRQMNPKHLR-KHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETAC 3388
G + + +L+ ++ LR I +V QEPILF TSI ENI YG + + T E+IE A
Sbjct: 456 AGNLLFNGTNLKDLDINWLRFLRIGVVGQEPILFATSIYENIRYGRE--DATREEIEAAR 513
Query: 3389 SKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTE 3568
+ AN FI +LP GY+T VGE+G QLSGGQKQRIAI RALIR+P+ILLLDEATSALDT
Sbjct: 514 AAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIRRALIRDPEILLLDEATSALDTA 573
Query: 3569 SEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFA 3748
SE +VQ AL+ + RT I+VAHRLST+ A I+V+ G+VVE GTH EL+ + YF
Sbjct: 574 SEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFN 633
Query: 3749 LTQKQSSNQSG 3781
L Q G
Sbjct: 634 LVTTQLGEDDG 644
>gi|1079107|pir||A47377 multidrug resistance protein Mdr50 - fruit fly
(Drosophila melanogaster)
Length = 1283
Score = 873 bits (2255), Expect = 0.0
Identities = 499/1263 (39%), Positives = 720/1263 (56%), Gaps = 21/1263 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+S FQL+RY + DR + +G++ + TG+ P S+I GN++ + + L + S
Sbjct: 44 VSYFQLFRYATKKDRALYVIGLLSAVGTGLTTPANSLIFGNLANDMIDLSGLLESGKSYR 103
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
++ A + +V Q L+ Y+G + +L +CF R +FF S++
Sbjct: 104 ADDAISTLLLD-KVRQFSLQNTYIGMIMLVCSYLSITCFNYAAHSQILTIRSKFFRSILH 162
Query: 401 QEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLI 580
Q++ WYD N SG +++++ ++L ++ +G +KV + + F+G +AF W L+L+
Sbjct: 163 QDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLV 222
Query: 581 MMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRY 760
++ P I YA A +AE L+ IRTV AF G+ E Y
Sbjct: 223 CLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAY 282
Query: 761 EDALEHGKKTGIKKSFLIGAGLAS-FFVIIYASYCLAFWVGTNFVYSGRLES---GTVLT 928
++ + K IK++ G G +F IYASY LAFW G V E+ GT++T
Sbjct: 283 KERVVAAKILNIKRNMFSGIGFGLLWFFFIYASYALAFWYGVGLVIESAYENYDAGTMIT 342
Query: 929 VFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRIS 1108
VFFSVMMGSM +G A G A G ++ +I++IPEI+ + ++ I
Sbjct: 343 VFFSVMMGSMNIGMAAPYIEAFGIAQGRLPKVFHIIEQIPEINPLMGRVKVNEPLT-TIE 401
Query: 1109 VNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILI 1288
+VEF YPTR +V IL ++L GQTVALVG SGCGKST IQL+QRFY+P AG +L
Sbjct: 402 FKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLF 461
Query: 1289 DDIPIEDFNIKYLRQL-VGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADF 1465
+ ++D +I +LR L +GVV QEP LF TSI +NIRYGR D + E+I A ANAA F
Sbjct: 462 NGTNLKDLDINWLRFLRIGVVGQEPILFATSIYENIRYGREDATREEIEAARAAANAAIF 521
Query: 1466 IKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSA 1645
IK P+G +TLVG+RG Q+SGGQKQRIAI RAL+R+P+ILLLDEATSALD SE+ VQ+A
Sbjct: 522 IKKLPKGYDTLVGERGAQLSGGQKQRIAIRRALIRDPEILLLDEATSALDTASEAKVQAA 581
Query: 1646 LENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQ--- 1816
LE S GRTTI++AHRLSTVR AD+I+V+ G+V+E GTH+ L+E K Y LV Q
Sbjct: 582 LEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLVTTQLGE 641
Query: 1817 -----------VFADVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXX 1963
++ + D K + +E + +S + + K ++ ++
Sbjct: 642 DDGSVLSPTGDIYKNFDIKDEDEEEIKVLSEDEDEDVMVTDEKNKKKKM----------- 690
Query: 1964 XXXXXXXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQ 2143
VK + ++++ +PEW+ +I G MP F++ F
Sbjct: 691 ----------KKVKDPNEVKP-MLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGS 739
Query: 2144 IINVFSNPDRDQ-MKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYR 2320
I+ + S D DQ ++++ + ++L FL+ V G + Q FG+A ERLT R+R ++
Sbjct: 740 ILQILSVKDNDQYVRENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFE 799
Query: 2321 NVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYG 2500
+LRQ+ +FD + G + RL+ DA ++ A R+G+I +I+++ G+ ++ YY
Sbjct: 800 AMLRQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIIQSISTLALGIALSMYYE 859
Query: 2501 WQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQT 2680
W + + +A PF+ + + AK MEN K A+E + NIRTV +L +
Sbjct: 860 WSLGLVALAFTPFILIAFYMQRTLMAKENMRPAKTMENCTKLAVEVVSNIRTVASLGREE 919
Query: 2681 KLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPE 2860
+ + L + RGL YG A S+ FF YAA +G + + + +L
Sbjct: 920 MFHQNYIGMLIPAVEISKRNTHFRGLVYGLARSLMFFAYAACMYYGTWCVIHRGILF--G 977
Query: 2861 NVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLS- 3037
+V +V A+ +I A ++ P K AA IF L +P I P S
Sbjct: 978 DVFKVSQAVIMGTASIANALAFAPNMQKGVSAAKTIFTFLRRQPSIVDRPGVSRDPWHSE 1037
Query: 3038 GEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEG 3217
G V+ +KV F YP R + +L+GL + V GQ +ALVGPSGCGKST I L++R YD EG
Sbjct: 1038 GYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEG 1097
Query: 3218 AVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKA 3397
A +D D+R ++ +LR + +VSQEPILFD +IRENI YG T ++I +AC K+
Sbjct: 1098 ATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARNVTDQEIISACKKS 1157
Query: 3398 NIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEK 3577
NIH+FI LP GY+TR+GEKG QLSGGQKQRIAIARALIRNPKI+LLDEATSALD ESEK
Sbjct: 1158 NIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESEK 1217
Query: 3578 QVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQ 3757
VQ ALDAA++ RT I +AHRLST+V++ I V +NG V E G H +L+A RG Y+ L +
Sbjct: 1218 VVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLLANRGLYYTLYK 1277
Query: 3758 KQS 3766
QS
Sbjct: 1278 LQS 1280
Score = 315 bits (807), Expect = 5e-84
Identities = 213/611 (34%), Positives = 319/611 (51%), Gaps = 24/611 (3%)
Frame = +2
Query: 2021 KANLFKILRYA-RPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGH 2197
+ + F++ RYA + + + G PA SL F + N D + + G
Sbjct: 43 QVSYFQLFRYATKKDRALYVIGLLSAVGTGLTTPANSLIFGNLANDMI--DLSGLLESGK 100
Query: 2198 FW----ALMFLVLAAVQGTSM--------LFQCSL-----FGVAAERLTMRIRSKVYRNV 2326
+ A+ L+L V+ S+ + CS F AA + IRSK +R++
Sbjct: 101 SYRADDAISTLLLDKVRQFSLQNTYIGMIMLVCSYLSITCFNYAAHSQILTIRSKFFRSI 160
Query: 2327 LRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQ 2506
L QD ++D + G + +R+ D ++ + ++ + + + G L +AF GWQ
Sbjct: 161 LHQDMKWYDF--NQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQ 218
Query: 2507 MAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKL 2686
++ + + P + L+ A + A A A+ IRTV+A + K
Sbjct: 219 LSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKE 278
Query: 2687 YNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFF----TYAAAFRFGLFLIFDKNVL-M 2851
+ + A NI + + G+ +G + FF +YA AF +G+ L+ +
Sbjct: 279 VAAYKERVVAAKILNIKRNMFSGIGFGL---LWFFFIYASYALAFWYGVGLVIESAYENY 335
Query: 2852 EPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ 3031
+ ++ V F++ IG AA Y + A +F+++E+ P I+ + +
Sbjct: 336 DAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAQGRLPKVFHIIEQIPEINPLMGRVKVNE 395
Query: 3032 LSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPL 3211
++ +V F+YP RP V IL LN+ + GQT+ALVGPSGCGKST I L++R YDP
Sbjct: 396 PLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQ 455
Query: 3212 EGAVTVDNNDLRQMNPKHLR-KHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETAC 3388
G + + +L+ ++ LR I +V QEPILF TSI ENI YG + + T E+IE A
Sbjct: 456 AGNLLFNGTNLKDLDINWLRFLRIGVVGQEPILFATSIYENIRYGRE--DATREEIEAAR 513
Query: 3389 SKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTE 3568
+ AN FI +LP GY+T VGE+G QLSGGQKQRIAI RALIR+P+ILLLDEATSALDT
Sbjct: 514 AAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIRRALIRDPEILLLDEATSALDTA 573
Query: 3569 SEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFA 3748
SE +VQ AL+ + RT I+VAHRLST+ A I+V+ G+VVE GTH EL+ + YF
Sbjct: 574 SEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFN 633
Query: 3749 LTQKQSSNQSG 3781
L Q G
Sbjct: 634 LVTTQLGEDDG 644
>gi|17567269|ref|NP_510128.1| P-GlycoProtein related (146.8 kD)
(pgp-14) [Caenorhabditis elegans]
gi|7499665|pir||T21268 hypothetical protein F22E10.3 - Caenorhabditis
elegans
gi|3876293|emb|CAA91801.1| Hypothetical protein F22E10.3
[Caenorhabditis elegans]
gi|40764042|gb|AAR89639.1| P-glycoprotein related (146.8 kD) (pgp-14)
[Caenorhabditis elegans]
Length = 1327
Score = 870 bits (2248), Expect = 0.0
Identities = 501/1261 (39%), Positives = 718/1261 (56%), Gaps = 20/1261 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+SI L+RY D L+L +G I + +GV P+++++ G V T + P S
Sbjct: 88 VSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRV-----TNALLVYPPTSK- 141
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAA--GFLQASCFMVICEKLSNRFRRQFFHSV 394
+F ++ +N Y++LG GIF + F+Q CF C ++ + R +F +SV
Sbjct: 142 --------QFRNKANENV--YIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSV 191
Query: 395 MRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLT 574
+RQ W+DKN SGT++ KL D++ER+REG GDK+G+ + A I VA+ Y+W L
Sbjct: 192 LRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLA 251
Query: 575 LIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECK 754
+M+ ++P IC AG IAEE L +RTV AFNGQE
Sbjct: 252 SMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVG 311
Query: 755 RYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLES-GTVLTV 931
RYE LE G+K + K F G FF +++ G + G + + G V V
Sbjct: 312 RYEAELEKGRKFAVWKGFWSGFFGGLFFFWLFSFLGCGMLYGAYLLKVGIITTPGDVFIV 371
Query: 932 FFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISV 1111
S+++G+ LG + A +AAS+Y+ IDR+P+ID YS G+ + GR+
Sbjct: 372 VMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKF 431
Query: 1112 NKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILID 1291
V F YP+R D KIL G++L +PG +VALVG SGCGKST + LL R Y P+AG + ID
Sbjct: 432 ENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTID 491
Query: 1292 DIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIK 1471
+ + NI++LR VG+V QEP LFN +I N+ G + E + K ANA DFI+
Sbjct: 492 GTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIE 551
Query: 1472 TFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALE 1651
P+G +TL+GD GVQ+SGGQKQR+AIAR L+R+PK+LLLDEATSALDA+SESIVQSAL
Sbjct: 552 KMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALN 611
Query: 1652 NASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVF-AD 1828
NAS+GRTTI+IAHRLST+R ADKI+ + G ++E G HE L+ G Y +LV AQ F AD
Sbjct: 612 NASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKAD 671
Query: 1829 VDDKPKKKEAE---------RRMSRQTSQRKGSVNFKTQESQVDX---XXXXXXXXXXXX 1972
+ + +E E R S TS R GS F+ S D
Sbjct: 672 PEATEEFEEEEIDLDDTSRSSRRSSMTSARSGSEAFRRGNSLNDSFSGSKRSAQADAENS 731
Query: 1973 XXXXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIIN 2152
G + A I + A+ ++Y LI+G +PA +L F +
Sbjct: 732 AFAANEAAIMAEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFE 791
Query: 2153 VFS-NPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVL 2329
F+ P +M + F + S L LF V +E L+MR R + +RN+L
Sbjct: 792 GFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLL 851
Query: 2330 RQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQM 2509
QDA+YFD P H+PG++ TRLA+DAPNIK+ +D R+ + A+A++ + IAF Y WQ+
Sbjct: 852 YQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVIYALAAIIANIAIAFIYCWQI 911
Query: 2510 AFL---VMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQT 2680
L ++ + F+ +G A Y + + ++AG+ A+E IEN++T+Q LT
Sbjct: 912 GILGTSLILLLAFVMIGLA----YKISLMNVEQIQNDDAGRIAIEIIENVKTIQLLTRCE 967
Query: 2681 KLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPE 2860
++ + + + K +I + Y S +F + G+ +I+ + +
Sbjct: 968 LFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGD--KSSD 1025
Query: 2861 NVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSG 3040
+ + + A+ + +A YFPE++KA AAG++FN++ +PR G G P++ G
Sbjct: 1026 DTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPR-TGDLMEGDRPEIRG 1084
Query: 3041 EVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGA 3220
+ V F YP+RP PI++GL GQT+ALVGPSG GKST I +LER YD GA
Sbjct: 1085 NILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGA 1144
Query: 3221 VTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKAN 3400
+ +D D+R+++ HLR +ALV QEP LF +IREN+ GL+ + E+I A AN
Sbjct: 1145 LRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGLK--DVPLEKINQALELAN 1202
Query: 3401 IHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQ 3580
++F+ LP G +T VGEKG QLSGGQKQRIAIARAL+R+PKILLLDEATSALD+ESE+
Sbjct: 1203 ANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERA 1262
Query: 3581 VQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQK 3760
VQ ALD A + RTCI +AHRLS+I N+ I+ + G+V E G H +L+ ++G Y+ L +K
Sbjct: 1263 VQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKK 1322
Query: 3761 Q 3763
Q
Sbjct: 1323 Q 1323
Score = 312 bits (800), Expect = 3e-83
Identities = 197/582 (33%), Positives = 303/582 (51%), Gaps = 2/582 (0%)
Frame = +2
Query: 86 LMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHEVI 265
L + +G + + G+ LP +++I G V + F + H +
Sbjct: 763 LYMFLGTVFALIRGLELPALALIFGWVFEGFTFV---------------PYGGRMMHRMA 807
Query: 266 QNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYDK--NTSGT 439
+ + +G G++ + + F V+ E LS RFR Q F +++ Q+ +++D + G
Sbjct: 808 MAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGK 867
Query: 440 LSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGL 619
L +L + ++ ++ +A I A+AF Y W + ++ SL ++ +
Sbjct: 868 LITRLASDAPNIKAVVDARMLQVIYALAAIIANIAIAFIYCWQIGILGTSLI-LLLAFVM 926
Query: 620 FXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIK 799
Q AG IA E++ +++T+ E Y+ + + K++ +K
Sbjct: 927 IGLAYKISLMNVEQIQNDDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELK 986
Query: 800 KSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQ 979
K + + +Y C + VG +Y G S ++M+G++A+ + Q
Sbjct: 987 KGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQ 1046
Query: 980 QFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKIL 1159
F A AA L+ +I R P EG P +I G I V+F+YP R I+
Sbjct: 1047 YFPEFVKAKTAAGMLFNIIYRKPRTGDLM-EGDRP-EIRGNILFENVKFSYPQRPLQPIM 1104
Query: 1160 KGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLV 1339
KG+ A GQTVALVG SG GKST I +L+RFY+ G + ID I ++ +LR +
Sbjct: 1105 KGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQM 1164
Query: 1340 GVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQ 1519
+V QEP LF +I +N+ G DV E I +AL+ ANA F+ P G++T VG++G Q
Sbjct: 1165 ALVGQEPRLFAGTIRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQ 1224
Query: 1520 MSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLS 1699
+SGGQKQRIAIARALVR+PKILLLDEATSALD+ESE VQ AL+ A GRT I IAHRLS
Sbjct: 1225 LSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLS 1284
Query: 1700 TVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFA 1825
+++N+D I+ + G+V E G H L+ QKG Y++L+ Q A
Sbjct: 1285 SIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQDLA 1326
>gi|39587988|emb|CAE57219.1| Hypothetical protein CBG00079
[Caenorhabditis briggsae]
Length = 1327
Score = 870 bits (2248), Expect = 0.0
Identities = 502/1267 (39%), Positives = 719/1267 (56%), Gaps = 26/1267 (2%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+SI L+RY D L+L +G I + +GV P+M+++ G V T + P S
Sbjct: 88 VSIPGLFRYGKRFDYLLLFIGTICAIISGVSQPIMALVSGRV-----TNALLVYPPTSK- 141
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAA--GFLQASCFMVICEKLSNRFRRQFFHSV 394
+F ++ +N Y++LG GIF + ++Q CF C ++ + R +F +SV
Sbjct: 142 --------QFRNKANENV--YIFLGIGIFISITNWIQYMCFQHCCSRVMAQMRHRFVYSV 191
Query: 395 MRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLT 574
+RQ W+DKN SGT++ KL D++ER+REG GDK+G+ + A I VA+ Y+W L
Sbjct: 192 LRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLA 251
Query: 575 LIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECK 754
+M+ ++P IC AG IAEE L +RTV AFNGQE
Sbjct: 252 SMMLGVAPVCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVG 311
Query: 755 RYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRL-------ES 913
RY+ LE G++ + K F G FF+ CL ++GT +Y L
Sbjct: 312 RYQTELEKGRRFAVWKGFWSGFFGGLFFL------CLFSFLGTGMLYGAYLLKVGIIGSP 365
Query: 914 GTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKI 1093
G V V S+++G+ LG + A +AA++Y+ IDR+P+ID YS G+ +
Sbjct: 366 GDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAATIYQTIDRVPKIDPYSKAGKRLPNV 425
Query: 1094 SGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDA 1273
GR+ V F YP+R + KIL G++L +PG +VALVG SGCGKST + LL R Y P+A
Sbjct: 426 VGRVKFENVHFRYPSRKEAKILNGLNLTVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEA 485
Query: 1274 GQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEAN 1453
G + ID + + NI +LR +VG+V QEP LFN +I N+ G + E + K AN
Sbjct: 486 GNVTIDGTDVRELNIDWLRNVVGIVQQEPILFNDTIHNNLLIGNPGATREKMIEVCKMAN 545
Query: 1454 AADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESI 1633
A DFI+ P+G +TL+GD GVQ+SGGQKQR+AIAR L+R+PKILLLDEATSALDA+SES+
Sbjct: 546 AHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKILLLDEATSALDAQSESV 605
Query: 1634 VQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHA 1813
VQSAL NA++GRTTI+IAHRLST+R ADKI+ + G ++E G HE L+ G Y +LV A
Sbjct: 606 VQSALNNAAKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVHLGGRYFDLVKA 665
Query: 1814 QVF-ADVDDKPKKKEAE---------RRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXX 1963
Q F AD + + +E E R S TS R GS F+ S D
Sbjct: 666 QQFKADPEATEEFEEEEIDLDDNSRSSRRSSMTSARSGSEAFQRGNSLNDSFSGSRRSAR 725
Query: 1964 XXX---XXXXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLF 2134
G + A I + A+ +IY LI+G +PA +L
Sbjct: 726 ADAENDAFAAHEAEVMAQDGQITAGYLDIFKNAKGNYIYMFLGTVFALIRGLELPALALI 785
Query: 2135 FSQIINVFS-NPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSK 2311
F + F+ P +M + F + S + LF + +E L++R R +
Sbjct: 786 FGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWISQVASSVLFAIVSENLSLRFRVQ 845
Query: 2312 VYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAF 2491
+RN+L QDA+YFD P H+PG++ TRLA+DAPNIK+ +D R+ + A+A++ + IAF
Sbjct: 846 SFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVIYALAAIIANIVIAF 905
Query: 2492 YYGWQMAFL---VMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQ 2662
Y WQ+A L ++ + F+ +G A Y + + + AG+TA+E IEN++T+Q
Sbjct: 906 IYCWQVAILGTSLILLLAFVMIGLA----YKISLMNIEQIKNDEAGRTAIEIIENVKTIQ 961
Query: 2663 ALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKN 2842
LT ++ + + + K +I + Y S +F + G+ +I+D +
Sbjct: 962 LLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSITQSFMYFMMCFTYAVGIRVIYDGD 1021
Query: 2843 VLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGT 3022
+ + + ++ + +A YFPE++KA AAGL+FN++ +PR G G
Sbjct: 1022 --KSSDVTFKGIISMMLGAVAVMNSAQYFPEFVKAKTAAGLLFNIIYRKPR-TGDLMEGD 1078
Query: 3023 YPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLY 3202
P++ G + V F YP+RP PI++GL GQT+ALVGPSG GKST I +LER Y
Sbjct: 1079 RPEIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFY 1138
Query: 3203 DPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIET 3382
D G + +D D+R ++ HLR +ALV QEP LF SIREN+ GL+ + E+I
Sbjct: 1139 DVTGGVLRIDGQDIRNLSLYHLRTQMALVGQEPRLFAGSIRENVCLGLK--DVPLEKINK 1196
Query: 3383 ACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALD 3562
A AN ++F+ LP G +T VGEKG QLSGGQKQRIAIARAL+R+PKILLLDEATSALD
Sbjct: 1197 ALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALD 1256
Query: 3563 TESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAY 3742
+ESE+ VQ ALD A + RTCI +AHRLS+I N+ I+ + G+V E G H +L+ K+G Y
Sbjct: 1257 SESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHAQLMQKKGRY 1316
Query: 3743 FALTQKQ 3763
+ L +KQ
Sbjct: 1317 YKLIKKQ 1323
Score = 310 bits (793), Expect = 2e-82
Identities = 197/585 (33%), Positives = 307/585 (51%), Gaps = 5/585 (0%)
Frame = +2
Query: 86 LMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHEVI 265
+ + +G + + G+ LP +++I G V + F + H +
Sbjct: 763 IYMFLGTVFALIRGLELPALALIFGWVFEGFTFV---------------PYGGRMMHRMA 807
Query: 266 QNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYDK--NTSGT 439
+ + +G G++ + + F ++ E LS RFR Q F +++ Q+ +++D + G
Sbjct: 808 MAVIAFASVGVGVWISQVASSVLFAIVSENLSLRFRVQSFRNLLYQDASYFDNPAHAPGK 867
Query: 440 LSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLI---MMSLSPFMMI 610
L +L + ++ ++ +A I +AF Y W + ++ ++ L F+MI
Sbjct: 868 LITRLASDAPNIKAVVDARMLQVIYALAAIIANIVIAFIYCWQVAILGTSLILLLAFVMI 927
Query: 611 CGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKT 790
GL + AG A E++ +++T+ E Y+ + + K++
Sbjct: 928 -GLAYKISLMNIEQIKNDE---AGRTAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRS 983
Query: 791 GIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQ 970
+KK + + +Y C + VG +Y G S S+M+G++A+
Sbjct: 984 ELKKGMIEAINYSITQSFMYFMMCFTYAVGIRVIYDGDKSSDVTFKGIISMMLGAVAVMN 1043
Query: 971 AGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADV 1150
+ Q F A AA L+ +I R P EG P +I G I V+F+YP R
Sbjct: 1044 SAQYFPEFVKAKTAAGLLFNIIYRKPRTGDLM-EGDRP-EIRGNILFENVKFSYPQRPLQ 1101
Query: 1151 KILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLR 1330
I+KG+ A GQTVALVG SG GKST I +L+RFY+ G + ID I + ++ +LR
Sbjct: 1102 PIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGVLRIDGQDIRNLSLYHLR 1161
Query: 1331 QLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEGLNTLVGDR 1510
+ +V QEP LF SI +N+ G DV E I +AL+ ANA F+ P G++T VG++
Sbjct: 1162 TQMALVGQEPRLFAGSIRENVCLGLKDVPLEKINKALELANANRFLANLPAGIDTDVGEK 1221
Query: 1511 GVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAH 1690
G Q+SGGQKQRIAIARALVR+PKILLLDEATSALD+ESE VQ AL+ A GRT I IAH
Sbjct: 1222 GGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAH 1281
Query: 1691 RLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFA 1825
RLS+++N+D I+ + G+V E G H L+++KG Y++L+ Q A
Sbjct: 1282 RLSSIQNSDLIVYIDKGKVQEAGNHAQLMQKKGRYYKLIKKQDLA 1326
>gi|4704820|gb|AAD28285.1| bile salt export pump [Homo sapiens]
Length = 1321
Score = 868 bits (2242), Expect = 0.0
Identities = 491/1272 (38%), Positives = 718/1272 (55%), Gaps = 35/1272 (2%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTL----------- 187
+ FQL+R++S+ D ++ VG + + G+ P + +I G ++ F+
Sbjct: 45 VGFFQLFRFSSSTDIWLMFVGSLCAFLHGIAQPGVLLIFGTMTDVFIDYDVELQELQIPG 104
Query: 188 -----GTIF-----LDPNSTASEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCF 337
TI L+ N T + E+I+ Y + + G++Q +
Sbjct: 105 KACVNNTIVWTNSSLNQNMTNGTRCGL-LNIESEMIKFASYYAGIAVAVLITGYIQICFW 163
Query: 338 MVICEKLSNRFRRQFFHSVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQM 517
++ + + R+ +F +MR EI W+D N+ G L+ + D++ ++ + D++ L Q
Sbjct: 164 VIAAARQIQKMRKFYFRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQR 223
Query: 518 MAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEE 697
M I GF + F W LTL+++S+SP + I YA AG +A+E
Sbjct: 224 MTSTICGFLLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVADE 283
Query: 698 VLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWV 877
V++S+RTV AF G++ E +RYE L ++ GI+K ++G + +I+ Y LAFW
Sbjct: 284 VISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYALAFWY 343
Query: 878 GTNFVYS-GRLESGTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEI 1054
G+ V G GT++ +F SV++G++ LG A T AA S++E IDR P I
Sbjct: 344 GSTLVLDEGEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKPII 403
Query: 1055 DAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKST 1234
D S +G +I G I + V F YP+R +VKIL +++ +PG+ ALVG SG GKST
Sbjct: 404 DCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMAIKPGEMTALVGPSGAGKST 463
Query: 1235 IIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDV 1414
+QL+QRFY+P G + +D I NI++LR +G+V QEP LF+T+I +NIRYGR D
Sbjct: 464 ALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDA 523
Query: 1415 SDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLD 1594
+ EDI +A KEANA +FI P+ +TLVG+ G QMSGGQKQR+AIARAL+RNPKILLLD
Sbjct: 524 TMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLD 583
Query: 1595 EATSALDAESESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETL 1774
ATSALD ESE++VQ L G T I +AHRLSTVR AD II + G +E GTHE L
Sbjct: 584 MATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEEL 643
Query: 1775 IEQKGLYHELVHAQVFA-------DVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQ-- 1927
+E+KG+Y LV Q D+ D + R SR + Q + + +
Sbjct: 644 LERKGVYFTLVTLQSQGNQALNEEDIKDATEDDMLARTFSRGSYQDSLRASIRQRSKSQL 703
Query: 1928 ---VDXXXXXXXXXXXXXXXXXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXL 2098
V A + +IL+++ PEW Y
Sbjct: 704 SYLVHEPPLAVVDHKSTYEEDRKDKDIPVQEEVEPAPVRRILKFSAPEWPYMLVGSVGAA 763
Query: 2099 IQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVA 2278
+ G V P ++ FSQI+ FS PD+++ + + L+F+ + V + Q F +
Sbjct: 764 VNGTVTPLYAFLFSQILGTFSIPDKEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKS 823
Query: 2279 AERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAI 2458
E LT R+R +R +L QD +FD ++SPG +TTRLATDA ++ A ++G I N+
Sbjct: 824 GELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSF 883
Query: 2459 ASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEA 2638
+V + IAF + W+++ +++ FPF+A+ A + G A+ D + +E G+ EA
Sbjct: 884 TNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQITNEA 943
Query: 2639 IENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFG 2818
+ NIRTV + + + + L+ P I KA I G + FA I F +A++R+G
Sbjct: 944 LSNIRTVAGIGKERRFIEALETELEKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYG 1003
Query: 2819 LFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRI 2998
+LI ++ + V RV+ A+ S +G A SY P Y KA +A F +L+ +P I
Sbjct: 1004 GYLISNEGLHFS--YVFRVISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLDRQPPI 1061
Query: 2999 DGMTSSGT-YPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKST 3175
++G + G++ F YP RP +L GL+V + PGQTLA VG SGCGKST
Sbjct: 1062 SVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKST 1121
Query: 3176 VISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPG 3355
I LLER YDP +G V +D +D +++N + LR +I +VSQEP+LF SI +NI YG
Sbjct: 1122 SIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTK 1181
Query: 3356 EYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILL 3535
E E++ A +A +H F+ LP+ YET VG +G+QLS G+KQRIAIARA++R+PKILL
Sbjct: 1182 EIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILL 1241
Query: 3536 LDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHN 3715
LDEATSALDTESEK VQVALD A + RTCIV+AHRLSTI NA I V+ G V+E+GTH
Sbjct: 1242 LDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHE 1301
Query: 3716 ELIAKRGAYFAL 3751
EL+A++GAY+ L
Sbjct: 1302 ELMAQKGAYYKL 1313
Score = 369 bits (947), Expect = e-100
Identities = 216/576 (37%), Positives = 321/576 (55%), Gaps = 4/576 (0%)
Frame = +2
Query: 92 LAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHEVIQN 271
+ VG + + G PL + + + LGT + +K R++ +
Sbjct: 755 MLVGSVGAAVNGTVTPLYAFLFSQI------LGTFSIP------DKEEQRSQINGV---- 798
Query: 272 CLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYD--KNTSGTLS 445
CL +V +GC FLQ F E L+ R R+ F +++ Q+IAW+D +N+ G L+
Sbjct: 799 CLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALT 858
Query: 446 NKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFX 625
+L + +V+ G ++G+ +AF++ W L+L+++ PF+ + G
Sbjct: 859 TRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQ 918
Query: 626 XXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKS 805
+ G I E L++IRTV + + E LE KT I+K+
Sbjct: 919 TRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKA 978
Query: 806 FLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQF 985
+ G A I++ + ++ G + + L V V +V++ + ALG+A
Sbjct: 979 NIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRAFSYT 1038
Query: 986 ATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKG 1165
+ A +AA ++++DR P I Y+T G+ G+I +FTYP+R D ++L G
Sbjct: 1039 PSYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNG 1098
Query: 1166 VSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGV 1345
+S+ PGQT+A VGSSGCGKST IQLL+RFY+PD G+++ID + N+++LR +G+
Sbjct: 1099 LSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGI 1158
Query: 1346 VSQEPNLFNTSIEQNIRYG--RSDVSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQ 1519
VSQEP LF SI NI+YG ++ E + A K+A DF+ + PE T VG +G Q
Sbjct: 1159 VSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQ 1218
Query: 1520 MSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLS 1699
+S G+KQRIAIARA+VR+PKILLLDEATSALD ESE VQ AL+ A GRT IVIAHRLS
Sbjct: 1219 LSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLS 1278
Query: 1700 TVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELV 1807
T++NAD I VM G V+E GTHE L+ QKG Y++LV
Sbjct: 1279 TIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLV 1314
Score = 336 bits (862), Expect = 2e-90
Identities = 199/519 (38%), Positives = 288/519 (55%), Gaps = 2/519 (0%)
Frame = +2
Query: 2255 QCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYR 2434
Q + +AA R ++R +R ++R + +FD +S G + TR + D I AI +
Sbjct: 159 QICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDC--NSVGELNTRFSDDINKINDAIADQ 216
Query: 2435 LGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMEN 2614
+ + S G + F+ GW++ +++++ P + +G A + + K
Sbjct: 217 MALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAK 276
Query: 2615 AGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFT 2794
AG A E I ++RTV A + + + +L I K I+ G GF + F
Sbjct: 277 AGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLC 336
Query: 2795 YAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFN 2974
YA AF +G L+ D+ P ++++ ++ +G A+ + AA IF
Sbjct: 337 YALAFWYGSTLVLDEGEYT-PGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIFE 395
Query: 2975 MLEEEPRIDGMTSSG-TYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVG 3151
++ +P ID M+ G ++ GE++ + V F YP RP V IL LN+ +KPG+ ALVG
Sbjct: 396 TIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMAIKPGEMTALVG 455
Query: 3152 PSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIREN 3331
PSG GKST + L++R YDP EG VTVD +D+R +N + LR I +V QEP+LF T+I EN
Sbjct: 456 PSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAEN 515
Query: 3332 IVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARAL 3511
I YG + + T E I A +AN + FI +LP ++T VGE G Q+SGGQKQR+AIARAL
Sbjct: 516 IRYGRE--DATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARAL 573
Query: 3512 IRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQ 3691
IRNPKILLLD ATSALD ESE VQ L T I VAHRLST+ A I+ ++G
Sbjct: 574 IRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGT 633
Query: 3692 VVEQGTHNELIAKRGAYFALTQKQS-SNQSGGAFDTSEA 3805
VE+GTH EL+ ++G YF L QS NQ+ D +A
Sbjct: 634 AVERGTHEELLERKGVYFTLVTLQSQGNQALNEEDIKDA 672
>gi|21536378|ref|NP_003733.2| ATP-binding cassette, sub-family B
(MDR/TAP), member 11; ABC member 16, MDR/TAP subfamily;
progressive familial intrahepatic cholestasis 2; bile
salt export pump [Homo sapiens]
Length = 1321
Score = 867 bits (2241), Expect = 0.0
Identities = 491/1272 (38%), Positives = 718/1272 (55%), Gaps = 35/1272 (2%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTL----------- 187
+ FQL+R++S+ D ++ VG + + G+ P + +I G ++ F+
Sbjct: 45 VGFFQLFRFSSSTDIWLMFVGSLCAFLHGIAQPGVLLIFGTMTDVFIDYDVELQELQIPG 104
Query: 188 -----GTIF-----LDPNSTASEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCF 337
TI L+ N T + E+I+ Y + + G++Q +
Sbjct: 105 KACVNNTIVWTNSSLNQNMTNGTRCGL-LNIESEMIKFASYYAGIAVAVLITGYIQICFW 163
Query: 338 MVICEKLSNRFRRQFFHSVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQM 517
++ + + R+ +F +MR EI W+D N+ G L+ + D++ ++ + D++ L Q
Sbjct: 164 VIAAARQIQKMRKFYFRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQR 223
Query: 518 MAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEE 697
M I GF + F W LTL+++S+SP + I YA AG +A+E
Sbjct: 224 MTSTICGFLLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVADE 283
Query: 698 VLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWV 877
V++S+RTV AF G++ E +RYE L ++ GI+K ++G + +I+ Y LAFW
Sbjct: 284 VISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYALAFWY 343
Query: 878 GTNFVYS-GRLESGTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEI 1054
G+ V G GT++ +F SV++G++ LG A T AA S++E IDR P I
Sbjct: 344 GSTLVLDEGEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKPII 403
Query: 1055 DAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKST 1234
D S +G +I G I + V F YP+R +VKIL +++ +PG+ ALVG SG GKST
Sbjct: 404 DCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKST 463
Query: 1235 IIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDV 1414
+QL+QRFY+P G + +D I NI++LR +G+V QEP LF+T+I +NIRYGR D
Sbjct: 464 ALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDA 523
Query: 1415 SDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLD 1594
+ EDI +A KEANA +FI P+ +TLVG+ G QMSGGQKQR+AIARAL+RNPKILLLD
Sbjct: 524 TMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLD 583
Query: 1595 EATSALDAESESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETL 1774
ATSALD ESE++VQ L G T I +AHRLSTVR AD II + G +E GTHE L
Sbjct: 584 MATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEEL 643
Query: 1775 IEQKGLYHELVHAQVFA-------DVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQ-- 1927
+E+KG+Y LV Q D+ D + R SR + Q + + +
Sbjct: 644 LERKGVYFTLVTLQSQGNQALNEEDIKDATEDDMLARTFSRGSYQDSLRASIRQRSKSQL 703
Query: 1928 ---VDXXXXXXXXXXXXXXXXXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXL 2098
V A + +IL+++ PEW Y
Sbjct: 704 SYLVHEPPLAVVDHKSTYEEDRKDKDIPVQEEVEPAPVRRILKFSAPEWPYMLVGSVGAA 763
Query: 2099 IQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVA 2278
+ G V P ++ FSQI+ FS PD+++ + + L+F+ + V + Q F +
Sbjct: 764 VNGTVTPLYAFLFSQILGTFSIPDKEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKS 823
Query: 2279 AERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAI 2458
E LT R+R +R +L QD +FD ++SPG +TTRLATDA ++ A ++G I N+
Sbjct: 824 GELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSF 883
Query: 2459 ASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEA 2638
+V + IAF + W+++ +++ FPF+A+ A + G A+ D + +E G+ EA
Sbjct: 884 TNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQITNEA 943
Query: 2639 IENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFG 2818
+ NIRTV + + + + L+ P I KA I G + FA I F +A++R+G
Sbjct: 944 LSNIRTVAGIGKERRFIEALETELEKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYG 1003
Query: 2819 LFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRI 2998
+LI ++ + V RV+ A+ S +G A SY P Y KA +A F +L+ +P I
Sbjct: 1004 GYLISNEGLHFS--YVFRVISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLDRQPPI 1061
Query: 2999 DGMTSSGT-YPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKST 3175
++G + G++ F YP RP +L GL+V + PGQTLA VG SGCGKST
Sbjct: 1062 SVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKST 1121
Query: 3176 VISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPG 3355
I LLER YDP +G V +D +D +++N + LR +I +VSQEP+LF SI +NI YG
Sbjct: 1122 SIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTK 1181
Query: 3356 EYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILL 3535
E E++ A +A +H F+ LP+ YET VG +G+QLS G+KQRIAIARA++R+PKILL
Sbjct: 1182 EIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILL 1241
Query: 3536 LDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHN 3715
LDEATSALDTESEK VQVALD A + RTCIV+AHRLSTI NA I V+ G V+E+GTH
Sbjct: 1242 LDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHE 1301
Query: 3716 ELIAKRGAYFAL 3751
EL+A++GAY+ L
Sbjct: 1302 ELMAQKGAYYKL 1313
Score = 369 bits (947), Expect = e-100
Identities = 216/576 (37%), Positives = 321/576 (55%), Gaps = 4/576 (0%)
Frame = +2
Query: 92 LAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHEVIQN 271
+ VG + + G PL + + + LGT + +K R++ +
Sbjct: 755 MLVGSVGAAVNGTVTPLYAFLFSQI------LGTFSIP------DKEEQRSQINGV---- 798
Query: 272 CLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYD--KNTSGTLS 445
CL +V +GC FLQ F E L+ R R+ F +++ Q+IAW+D +N+ G L+
Sbjct: 799 CLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALT 858
Query: 446 NKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFX 625
+L + +V+ G ++G+ +AF++ W L+L+++ PF+ + G
Sbjct: 859 TRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQ 918
Query: 626 XXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKS 805
+ G I E L++IRTV + + E LE KT I+K+
Sbjct: 919 TRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKA 978
Query: 806 FLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQF 985
+ G A I++ + ++ G + + L V V +V++ + ALG+A
Sbjct: 979 NIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRAFSYT 1038
Query: 986 ATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKG 1165
+ A +AA ++++DR P I Y+T G+ G+I +FTYP+R D ++L G
Sbjct: 1039 PSYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNG 1098
Query: 1166 VSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGV 1345
+S+ PGQT+A VGSSGCGKST IQLL+RFY+PD G+++ID + N+++LR +G+
Sbjct: 1099 LSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGI 1158
Query: 1346 VSQEPNLFNTSIEQNIRYG--RSDVSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQ 1519
VSQEP LF SI NI+YG ++ E + A K+A DF+ + PE T VG +G Q
Sbjct: 1159 VSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQ 1218
Query: 1520 MSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLS 1699
+S G+KQRIAIARA+VR+PKILLLDEATSALD ESE VQ AL+ A GRT IVIAHRLS
Sbjct: 1219 LSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLS 1278
Query: 1700 TVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELV 1807
T++NAD I VM G V+E GTHE L+ QKG Y++LV
Sbjct: 1279 TIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLV 1314
Score = 336 bits (861), Expect = 3e-90
Identities = 199/519 (38%), Positives = 288/519 (55%), Gaps = 2/519 (0%)
Frame = +2
Query: 2255 QCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYR 2434
Q + +AA R ++R +R ++R + +FD +S G + TR + D I AI +
Sbjct: 159 QICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDC--NSVGELNTRFSDDINKINDAIADQ 216
Query: 2435 LGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMEN 2614
+ + S G + F+ GW++ +++++ P + +G A + + K
Sbjct: 217 MALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAK 276
Query: 2615 AGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFT 2794
AG A E I ++RTV A + + + +L I K I+ G GF + F
Sbjct: 277 AGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLC 336
Query: 2795 YAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFN 2974
YA AF +G L+ D+ P ++++ ++ +G A+ + AA IF
Sbjct: 337 YALAFWYGSTLVLDEGEYT-PGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIFE 395
Query: 2975 MLEEEPRIDGMTSSG-TYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVG 3151
++ +P ID M+ G ++ GE++ + V F YP RP V IL LN+ +KPG+ ALVG
Sbjct: 396 TIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVG 455
Query: 3152 PSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIREN 3331
PSG GKST + L++R YDP EG VTVD +D+R +N + LR I +V QEP+LF T+I EN
Sbjct: 456 PSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAEN 515
Query: 3332 IVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARAL 3511
I YG + + T E I A +AN + FI +LP ++T VGE G Q+SGGQKQR+AIARAL
Sbjct: 516 IRYGRE--DATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARAL 573
Query: 3512 IRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQ 3691
IRNPKILLLD ATSALD ESE VQ L T I VAHRLST+ A I+ ++G
Sbjct: 574 IRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGT 633
Query: 3692 VVEQGTHNELIAKRGAYFALTQKQS-SNQSGGAFDTSEA 3805
VE+GTH EL+ ++G YF L QS NQ+ D +A
Sbjct: 634 AVERGTHEELLERKGVYFTLVTLQSQGNQALNEEDIKDA 672
>gi|18496818|gb|AAL74250.1| ABC transporter AbcB3 [Dictyostelium
discoideum]
Length = 1432
Score = 867 bits (2240), Expect = 0.0
Identities = 496/1284 (38%), Positives = 723/1284 (55%), Gaps = 43/1284 (3%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLD-PNST 217
+ L+R+ D++++ +G I + G +P +S++ G V F T F D PN
Sbjct: 163 VPFLSLFRFADNTDKVLMFLGTIAAVINGAAMPTVSLVFGLVVDAFKP--TQFNDDPNYD 220
Query: 218 ASEKAAARAEFSHEVIQNCLKYVY-LGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSV 394
++ +++ Y+ LG G+F +L+ + +M+ E+ ++R RR++ S
Sbjct: 221 I-----------YDTVRSISFYLLMLGGGVFVLSYLETTLWMIAGERQTSRIRREYLEST 269
Query: 395 MRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLT 574
+RQEI W+D N + LS+++ + E G+KVG + F+ GF + FT W LT
Sbjct: 270 LRQEIGWFDTNKANELSSRINSDTVLFEEAIGEKVGRFIHFFSTFVAGFVIGFTKGWQLT 329
Query: 575 LIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECK 754
L++ S+SP + I G F Y+ AGG+AEE + SIRTV F+G++
Sbjct: 330 LVITSVSPLLAIGGFFTAKMMTQMTKLGQEAYSRAGGVAEENIGSIRTVATFSGEKLAID 389
Query: 755 RYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVG--------TNFVYSGRLE 910
+Y + L+ + G K+SF G GL +I +Y LAFW G TN V
Sbjct: 390 KYSNNLKDARTVGYKRSFFNGLGLGFVQFVILGTYALAFWYGSTLISNKVTNSVSDRPWT 449
Query: 911 SGTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSK 1090
G V++VFF+V++G+ ++GQA A GAA +++VIDR + + +ST G P
Sbjct: 450 GGDVVSVFFAVIIGATSIGQASPCLALFAQGRGAAYKIFQVIDRQSKANPFSTRGIKPET 509
Query: 1091 ISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPD 1270
+SG I V F YP+R DV I G +L +PGQTV LVG SG GKSTII LL+RFY+P
Sbjct: 510 LSGEIEFKDVGFHYPSRPDVPIFNGFNLKIKPGQTVGLVGDSGGGKSTIISLLERFYDPC 569
Query: 1271 AGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEA 1450
G+IL+D I FN++ LRQ +G+V+QEP LF T+I +NIRYG+ + ++I A K A
Sbjct: 570 QGEILLDGEDIRKFNVRGLRQKIGLVNQEPVLFATTISENIRYGKEGATQDEIEEAAKLA 629
Query: 1451 NAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESES 1630
NA FI P+G NTLVG++GVQMSGGQ+QRIAIARA+++NP ILLLDE+TSALDAES
Sbjct: 630 NAHSFISQLPQGYNTLVGEKGVQMSGGQRQRIAIARAVIKNPNILLLDESTSALDAESTK 689
Query: 1631 IVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVH 1810
+VQ AL+ +GRTTIVIAH LST+RNAD II +K G +E GTH+ L+ ++GLY +LV
Sbjct: 690 LVQEALDVLMKGRTTIVIAHNLSTIRNADVIIYIKKGVAVERGTHDELMAKQGLYFDLVE 749
Query: 1811 AQVFADVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXX 1990
Q + + + RR S +++ ++ +
Sbjct: 750 KQSHQQMYNLLENGTRSRRSSTFSAEVNPLLDSFHVSKRSLRKNESESNKKDKEDSNNKK 809
Query: 1991 XXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPD 2170
+ + ++++Y RPE + GAV P F++ F++++ +F NPD
Sbjct: 810 KKKSNKKKVEEVPMSRVVKYNRPELGLWCFGFLSAVGTGAVYPGFAMVFTEMLTIFQNPD 869
Query: 2171 RDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYF 2350
+ + +F ALMF+ LA G S FQ LF V E+LT R+R + ++RQD +F
Sbjct: 870 PNYLTDHANFVALMFVALAVGAGISNFFQGFLFSVIGEKLTYRLRRDCFAAIMRQDVGWF 929
Query: 2351 DMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAI 2530
D+P++S G++T+ LATDA ++ RLG + I ++ GGL IAFY GWQ+ +++A
Sbjct: 930 DLPENSTGKLTSHLATDAALVQGMTSQRLGIVLQNILTMVGGLVIAFYSGWQLTLVIIAC 989
Query: 2531 FPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHL 2710
FP + + + M+ G ++ D AG+ A EAI IRTV + T + ++ ++
Sbjct: 990 FPLVVITSKVQMQILAGFSSKDG--CGPAGQVASEAISGIRTVASFTTEKQVVELYKKQQ 1047
Query: 2711 DAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRF-------GLFLIFDK---------- 2839
P I KA I G +GF I F Y +F + G+F DK
Sbjct: 1048 KGPSSEGIKKAHISGFAFGFTQLILFCVYCLSFWYGGKLVGSGVFGATDKEISDNCTPQT 1107
Query: 2840 ---------------NVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFN 2974
N + ++ RV FAI S +G A+S+ P+ KA AA +F
Sbjct: 1108 IPYLWKDYDTCERAQNTIYGFNSMTRVFFAIVMSAIGVGQASSFAPDLAKAKAAAVSVFK 1167
Query: 2975 MLEEEPRIDGMTSSGTYPQL-SGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVG 3151
+L+ +ID T G + G+++ + F YP RP + +G + ++ G T ALVG
Sbjct: 1168 LLDTPSKIDPTTEDGDRIDIVGGDIEFKNLHFSYPTRPDNSVFRGFTLTLQSGTTTALVG 1227
Query: 3152 PSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIREN 3331
SG GKST +SLL+R Y+P+ G + +D ++++ +N +HLR LV QEP LF +I +N
Sbjct: 1228 DSGGGKSTCLSLLQRFYNPVVGEIFIDGHNIKNLNVRHLRHLFGLVGQEPTLFSGTIADN 1287
Query: 3332 IVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARAL 3511
I YG + T E+IE A +N H FI +LP+GY T +GEK TQLSGGQKQRIAIARA+
Sbjct: 1288 IRYGKH--DATQEEIEEASKLSNSHSFIIDLPNGYNTELGEKYTQLSGGQKQRIAIARAI 1345
Query: 3512 IRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQ 3691
IRNPKILLLDE+TSALD +S K VQ AL+ K RT IV+AH L TI NA CI V+ GQ
Sbjct: 1346 IRNPKILLLDESTSALDADSTKLVQEALENVMKGRTTIVIAHNLLTIQNADCIAYVRAGQ 1405
Query: 3692 VVEQGTHNELIAKRGAYFALTQKQ 3763
++E+GTH+EL+ G Y L Q
Sbjct: 1406 IIERGTHDELLEAEGPYSQLWYNQ 1429
Score = 380 bits (975), Expect = e-103
Identities = 229/575 (39%), Positives = 329/575 (56%), Gaps = 15/575 (2%)
Frame = +2
Query: 2096 LIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHF------WALMFLVLAAVQGTSML-- 2251
+I GA MP SL F +++ F Q D ++ ++ F +L G +L
Sbjct: 188 VINGAAMPTVSLVFGLVVDAFKPT---QFNDDPNYDIYDTVRSISFYLLMLGGGVFVLSY 244
Query: 2252 FQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDY 2431
+ +L+ +A ER T RIR + + LRQ+ +FD K + +++R+ +D + AI
Sbjct: 245 LETTLWMIAGERQTSRIRREYLESTLRQEIGWFDTNKAN--ELSSRINSDTVLFEEAIGE 302
Query: 2432 RLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEME 2611
++G + ++ G I F GWQ+ ++ ++ P +A+G K +
Sbjct: 303 KVGRFIHFFSTFVAGFVIGFTKGWQLTLVITSVSPLLAIGGFFTAKMMTQMTKLGQEAYS 362
Query: 2612 NAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFF 2791
AG A E I +IRTV + + + + ++L ++ GL GF +
Sbjct: 363 RAGGVAEENIGSIRTVATFSGEKLAIDKYSNNLKDARTVGYKRSFFNGLGLGFVQFVILG 422
Query: 2792 TYAAAFRFGLFLIFDK---NVLMEP---ENVLRVLFAISFSFGTIGFAASYFPEYIKATF 2953
TYA AF +G LI +K +V P +V+ V FA+ +IG A+ + +
Sbjct: 423 TYALAFWYGSTLISNKVTNSVSDRPWTGGDVVSVFFAVIIGATSIGQASPCLALFAQGRG 482
Query: 2954 AAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKLNKVFFRYPERPAVPILQGLNVHVKPG 3130
AA IF +++ + + + ++ G P+ LSGE++ V F YP RP VPI G N+ +KPG
Sbjct: 483 AAYKIFQVIDRQSKANPFSTRGIKPETLSGEIEFKDVGFHYPSRPDVPIFNGFNLKIKPG 542
Query: 3131 QTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILF 3310
QT+ LVG SG GKST+ISLLER YDP +G + +D D+R+ N + LR+ I LV+QEP+LF
Sbjct: 543 QTVGLVGDSGGGKSTIISLLERFYDPCQGEILLDGEDIRKFNVRGLRQKIGLVNQEPVLF 602
Query: 3311 DTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQR 3490
T+I ENI YG + T ++IE A AN H FI +LP GY T VGEKG Q+SGGQ+QR
Sbjct: 603 ATTISENIRYGKEGA--TQDEIEEAAKLANAHSFISQLPQGYNTLVGEKGVQMSGGQRQR 660
Query: 3491 IAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCI 3670
IAIARA+I+NP ILLLDE+TSALD ES K VQ ALD K RT IV+AH LSTI NA I
Sbjct: 661 IAIARAVIKNPNILLLDESTSALDAESTKLVQEALDVLMKGRTTIVIAHNLSTIRNADVI 720
Query: 3671 MVVKNGQVVEQGTHNELIAKRGAYFALTQKQSSNQ 3775
+ +K G VE+GTH+EL+AK+G YF L +KQS Q
Sbjct: 721 IYIKKGVAVERGTHDELMAKQGLYFDLVEKQSHQQ 755
>gi|12643301|sp|O95342|AB11_HUMAN Bile salt export pump (ATP-binding
cassette, sub-family B, member 11)
gi|3873243|gb|AAC77455.1| bile salt export pump [Homo sapiens]
Length = 1321
Score = 866 bits (2238), Expect = 0.0
Identities = 490/1272 (38%), Positives = 718/1272 (55%), Gaps = 35/1272 (2%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTL----------- 187
+ FQL+R++S+ D ++ VG + + G+ P + +I G ++ F+
Sbjct: 45 VGFFQLFRFSSSTDIWLMFVGSLCAFLHGIAQPGVLLIFGTMTDVFIDYDVELQELQIPG 104
Query: 188 -----GTIF-----LDPNSTASEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCF 337
TI L+ N T + E+I+ Y + + G++Q +
Sbjct: 105 KACVNNTIVWTNSSLNQNMTNGTRCGL-LNIESEMIKFASYYAGIAVAVLITGYIQICFW 163
Query: 338 MVICEKLSNRFRRQFFHSVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQM 517
++ + + R+ +F +MR EI W+D N+ G L+ + D++ ++ + D++ L Q
Sbjct: 164 VIAAARQIQKMRKFYFRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQR 223
Query: 518 MAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEE 697
M I GF + F W LTL+++S+SP + I YA AG +A+E
Sbjct: 224 MTSTICGFLLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVADE 283
Query: 698 VLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWV 877
V++S+RTV AF G++ E +RYE L ++ GI+K ++G + +I+ Y +AFW
Sbjct: 284 VISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYAVAFWY 343
Query: 878 GTNFVYS-GRLESGTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEI 1054
G+ V G GT++ +F SV++G++ LG A T AA S++E IDR P I
Sbjct: 344 GSTLVLDEGEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKPII 403
Query: 1055 DAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKST 1234
D S +G +I G I + V F YP+R +VKIL +++ +PG+ ALVG SG GKST
Sbjct: 404 DCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKST 463
Query: 1235 IIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDV 1414
+QL+QRFY+P G + +D I NI++LR +G+V QEP LF+T+I +NIRYGR D
Sbjct: 464 ALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDA 523
Query: 1415 SDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLD 1594
+ EDI +A KEANA +FI P+ +TLVG+ G QMSGGQKQR+AIARAL+RNPKILLLD
Sbjct: 524 TMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLD 583
Query: 1595 EATSALDAESESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETL 1774
ATSALD ESE++VQ L G T I +AHRLSTVR AD II + G +E GTHE L
Sbjct: 584 MATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEEL 643
Query: 1775 IEQKGLYHELVHAQVFA-------DVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQ-- 1927
+E+KG+Y LV Q D+ D + R SR + Q + + +
Sbjct: 644 LERKGVYFTLVTLQSQGNQALNEEDIKDATEDDMLARTFSRGSYQDSLRASIRQRSKSQL 703
Query: 1928 ---VDXXXXXXXXXXXXXXXXXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXL 2098
V A + +IL+++ PEW Y
Sbjct: 704 SYLVHEPPLAVVDHKSTYEEDRKDKDIPVQEEVEPAPVRRILKFSAPEWPYMLVGSVGAA 763
Query: 2099 IQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVA 2278
+ G V P ++ FSQI+ FS PD+++ + + L+F+ + V + Q F +
Sbjct: 764 VNGTVTPLYAFLFSQILGTFSIPDKEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKS 823
Query: 2279 AERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAI 2458
E LT R+R +R +L QD +FD ++SPG +TTRLATDA ++ A ++G I N+
Sbjct: 824 GELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSF 883
Query: 2459 ASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEA 2638
+V + IAF + W+++ +++ FPF+A+ A + G A+ D + +E G+ EA
Sbjct: 884 TNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQITNEA 943
Query: 2639 IENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFG 2818
+ NIRTV + + + + L+ P I KA I G + FA I F +A++R+G
Sbjct: 944 LSNIRTVAGIGKERRFIEALETELEKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYG 1003
Query: 2819 LFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRI 2998
+LI ++ + V RV+ A+ S +G A SY P Y KA +A F +L+ +P I
Sbjct: 1004 GYLISNEGLHFS--YVFRVISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLDRQPPI 1061
Query: 2999 DGMTSSGT-YPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKST 3175
++G + G++ F YP RP +L GL+V + PGQTLA VG SGCGKST
Sbjct: 1062 SVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKST 1121
Query: 3176 VISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPG 3355
I LLER YDP +G V +D +D +++N + LR +I +VSQEP+LF SI +NI YG
Sbjct: 1122 SIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTK 1181
Query: 3356 EYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILL 3535
E E++ A +A +H F+ LP+ YET VG +G+QLS G+KQRIAIARA++R+PKILL
Sbjct: 1182 EIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILL 1241
Query: 3536 LDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHN 3715
LDEATSALDTESEK VQVALD A + RTCIV+AHRLSTI NA I V+ G V+E+GTH
Sbjct: 1242 LDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHE 1301
Query: 3716 ELIAKRGAYFAL 3751
EL+A++GAY+ L
Sbjct: 1302 ELMAQKGAYYKL 1313
Score = 369 bits (947), Expect = e-100
Identities = 216/576 (37%), Positives = 321/576 (55%), Gaps = 4/576 (0%)
Frame = +2
Query: 92 LAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHEVIQN 271
+ VG + + G PL + + + LGT + +K R++ +
Sbjct: 755 MLVGSVGAAVNGTVTPLYAFLFSQI------LGTFSIP------DKEEQRSQINGV---- 798
Query: 272 CLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYD--KNTSGTLS 445
CL +V +GC FLQ F E L+ R R+ F +++ Q+IAW+D +N+ G L+
Sbjct: 799 CLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALT 858
Query: 446 NKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFX 625
+L + +V+ G ++G+ +AF++ W L+L+++ PF+ + G
Sbjct: 859 TRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQ 918
Query: 626 XXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKS 805
+ G I E L++IRTV + + E LE KT I+K+
Sbjct: 919 TRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKA 978
Query: 806 FLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQF 985
+ G A I++ + ++ G + + L V V +V++ + ALG+A
Sbjct: 979 NIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRAFSYT 1038
Query: 986 ATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKG 1165
+ A +AA ++++DR P I Y+T G+ G+I +FTYP+R D ++L G
Sbjct: 1039 PSYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNG 1098
Query: 1166 VSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGV 1345
+S+ PGQT+A VGSSGCGKST IQLL+RFY+PD G+++ID + N+++LR +G+
Sbjct: 1099 LSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGI 1158
Query: 1346 VSQEPNLFNTSIEQNIRYG--RSDVSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQ 1519
VSQEP LF SI NI+YG ++ E + A K+A DF+ + PE T VG +G Q
Sbjct: 1159 VSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQ 1218
Query: 1520 MSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLS 1699
+S G+KQRIAIARA+VR+PKILLLDEATSALD ESE VQ AL+ A GRT IVIAHRLS
Sbjct: 1219 LSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLS 1278
Query: 1700 TVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELV 1807
T++NAD I VM G V+E GTHE L+ QKG Y++LV
Sbjct: 1279 TIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLV 1314
Score = 336 bits (862), Expect = 2e-90
Identities = 199/519 (38%), Positives = 288/519 (55%), Gaps = 2/519 (0%)
Frame = +2
Query: 2255 QCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYR 2434
Q + +AA R ++R +R ++R + +FD +S G + TR + D I AI +
Sbjct: 159 QICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDC--NSVGELNTRFSDDINKINDAIADQ 216
Query: 2435 LGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMEN 2614
+ + S G + F+ GW++ +++++ P + +G A + + K
Sbjct: 217 MALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAK 276
Query: 2615 AGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFT 2794
AG A E I ++RTV A + + + +L I K I+ G GF + F
Sbjct: 277 AGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLC 336
Query: 2795 YAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFN 2974
YA AF +G L+ D+ P ++++ ++ +G A+ + AA IF
Sbjct: 337 YAVAFWYGSTLVLDEGEYT-PGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIFE 395
Query: 2975 MLEEEPRIDGMTSSG-TYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVG 3151
++ +P ID M+ G ++ GE++ + V F YP RP V IL LN+ +KPG+ ALVG
Sbjct: 396 TIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVG 455
Query: 3152 PSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIREN 3331
PSG GKST + L++R YDP EG VTVD +D+R +N + LR I +V QEP+LF T+I EN
Sbjct: 456 PSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAEN 515
Query: 3332 IVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARAL 3511
I YG + + T E I A +AN + FI +LP ++T VGE G Q+SGGQKQR+AIARAL
Sbjct: 516 IRYGRE--DATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARAL 573
Query: 3512 IRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQ 3691
IRNPKILLLD ATSALD ESE VQ L T I VAHRLST+ A I+ ++G
Sbjct: 574 IRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGT 633
Query: 3692 VVEQGTHNELIAKRGAYFALTQKQS-SNQSGGAFDTSEA 3805
VE+GTH EL+ ++G YF L QS NQ+ D +A
Sbjct: 634 AVERGTHEELLERKGVYFTLVTLQSQGNQALNEEDIKDA 672
>gi|13641444|gb|AAK31736.1| p-glycoprotein [Mucor racemosus]
Length = 1292
Score = 863 bits (2229), Expect = 0.0
Identities = 493/1275 (38%), Positives = 729/1275 (56%), Gaps = 27/1275 (2%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+SIF+L+++ +T D L++ + SC TG P+ + GNV + LG ++ N
Sbjct: 35 VSIFRLFQFATTRDLLLICIAGFCSCTTGAIQPISILFFGNVLKK---LGEAIVEGNDLM 91
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
E + +I+ YVYLG G+ A ++ +++ E + R R+ + HS++R
Sbjct: 92 --------EATMPIIK---LYVYLGTGVMTAAYISNCLWVLTGENQARRIRQLYVHSILR 140
Query: 401 QEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLI 580
QE++W+DK+ G+L+ +L +++ +++G +K G AQFI G +VAF+ W L+++
Sbjct: 141 QEMSWFDKSEEGSLTTRLSADVQLIQDGISEKFGQFLMCFAQFIAGCSVAFSKGWRLSIV 200
Query: 581 MMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRY 760
M++++P + G YA AG I+E+V IRTV +F+ Q KRY
Sbjct: 201 MIAVTPAIACTGGVMGILVTKYTVETQDAYADAGSISEQVFAGIRTVYSFSLQNRFAKRY 260
Query: 761 EDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFS 940
E+ L+ + GIK+ ++G GL F ++A Y L+FW G+ V+ ++ TVL VF S
Sbjct: 261 EEKLDKAMRAGIKRGIILGTGLGIFMFCLFAMYGLSFWYGSRLVHDHIMDGSTVLVVFLS 320
Query: 941 VMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKV 1120
+MMG +L Q A + +A AA ++E I R+P+ID S +G PS++ G + V
Sbjct: 321 MMMGEFSLLQLPTNLAAVSSASAAAYKIFETIKRVPDIDTSSPDGVIPSQVLGELEFKHV 380
Query: 1121 EFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIP 1300
+F YPTR D ILK +SL +PG TVA VG SG GKST +QLLQRFY+P +G + +D
Sbjct: 381 KFRYPTRPDTIILKDLSLKIKPGMTVAFVGPSGSGKSTSVQLLQRFYDPMSGSVSLDGKN 440
Query: 1301 IEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYG--RSDVSDEDIARALKEANAADFIKT 1474
+++ N+K+LRQ +GVVSQEP LFNTSI QN+ G ++S E+I A K+AN FIK
Sbjct: 441 LKELNVKWLRQQIGVVSQEPVLFNTSIRQNLMMGSENRNISMEEITAACKKANCHSFIKQ 500
Query: 1475 FPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALEN 1654
P+G +TLVG+ G +SGGQKQRIAIARA+++NP ILLLDEATSALD +SE +VQ AL+
Sbjct: 501 LPKGYSTLVGEHGGMLSGGQKQRIAIARAILKNPAILLLDEATSALDTQSERLVQKALDE 560
Query: 1655 ASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFA--- 1825
A+ RTTIV+AHRLSTVRNAD I+VM+ G ++E GTH+ LI + G+Y ELV Q
Sbjct: 561 AAANRTTIVVAHRLSTVRNADLIVVMQHGDLIEQGTHDDLIAKGGVYSELVKKQQIQTSS 620
Query: 1826 -DVDDKPKKKEAER------RMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXX 1984
+ ++ K+E E+ R RK + +
Sbjct: 621 NNTHNRKTKQEEEQEDEILLRNEAMEVNRKSCIELNRASNNASIISVPAARKSRFSVLDG 680
Query: 1985 XXXXXXXXXGA------VKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQI 2146
A +KA ++K+ RP+W + I G V P ++LFF+++
Sbjct: 681 FGREAASRKEAQEKHAKMKAPVWKVFMQMRPQWGWCMLGSIGACIAGTVFPLYALFFAKV 740
Query: 2147 INVFS-NPDRDQMKKDG-HFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYR 2320
I + + N D+D +G + ++ +F++L Q F +A + T +RS ++
Sbjct: 741 ITMLNENDDKDYGPMEGPNMYSFLFVILGMFAFLGFALQTVSFEIAGAKYTKTLRSMLFV 800
Query: 2321 NVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYG 2500
+ ++Q+ YFD +++ G +T++LA DA N+ I + + G+ IAF +
Sbjct: 801 SFMKQEIGYFDRDENNVGSLTSKLAVDAKNVNEMITRAWPDVVQIAFTSAIGMTIAFMHS 860
Query: 2501 WQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQT 2680
W++ ++M + P + K G S + E + + A EAI+ IRTV AL Q+
Sbjct: 861 WKLTLIIMCMTPLIVGAAGWNSKVQEGFEGSTKEANEQSAEVASEAIKEIRTVTALNKQS 920
Query: 2681 KLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPE 2860
+ + + PH KA + + +T A AF G LI N ++
Sbjct: 921 YFEERYYNATERPHRLAQRKAYTSSIGFALLQGTSLYTNAVAFYAGSKLITQGN--LDLS 978
Query: 2861 NVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ--- 3031
+++ + +I +G ++ + + KA AA F +L +P ID G P+
Sbjct: 979 DMVITMMSIMIMADGVGRSSIFVSTFAKAKIAAITTFEVLNRQPAIDS-ELEGIEPEGED 1037
Query: 3032 LSGEVKLNKVFFRYPERPAVPILQG-LNVHVKPGQTLALVGPSGCGKSTVISLLERLYDP 3208
+ G++ + + FRYP RP +PI G N+ K GQT+ALVGPSG GKST I +L+R YDP
Sbjct: 1038 IDGDIDFSSIAFRYPARPDIPIFDGEFNLKGKQGQTIALVGPSGSGKSTTIGMLQRWYDP 1097
Query: 3209 LEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPG-EYTHEQIETA 3385
L G V VDN++++ +LR H+ALVSQEP LFD +I ENI +G+ E T E++E
Sbjct: 1098 LSGTVRVDNHNVKSYTLGNLRSHMALVSQEPTLFDMTIGENIRFGVDDSKEVTQEEVEAV 1157
Query: 3386 CSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDT 3565
C ANIH FI LP GY+ RVG+KG+QLSGGQKQRIAIARALIR PKILLLDEATSALD+
Sbjct: 1158 CKSANIHNFIVSLPKGYDQRVGDKGSQLSGGQKQRIAIARALIRKPKILLLDEATSALDS 1217
Query: 3566 ESEKQVQVALDAAAKD--RTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGA 3739
ESEK VQ ALD ++ RT I +AHRLSTI NA I V+K+G+V+EQG H +L+ G
Sbjct: 1218 ESEKLVQKALDNIIQEGGRTTITIAHRLSTITNADLICVIKDGKVIEQGNHWQLLKLDGV 1277
Query: 3740 YFALTQKQSSNQSGG 3784
Y +L Q+QS + S G
Sbjct: 1278 YKSLVQQQSLSSSSG 1292
>gi|39594939|emb|CAE70807.1| Hypothetical protein CBG17569
[Caenorhabditis briggsae]
Length = 1224
Score = 863 bits (2229), Expect = 0.0
Identities = 497/1238 (40%), Positives = 709/1238 (57%), Gaps = 2/1238 (0%)
Frame = +2
Query: 56 LYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAA 235
+++ TS ++L+ +GI S TG+ P MS G VSQ VT+ + ++
Sbjct: 31 IFKCTSCFEKLLFMLGIFFSLLTGLCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEK 90
Query: 236 ARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAW 415
A F ++ L + + GC F G LQ S + + + R R+Q+ ++R++ +
Sbjct: 91 AYEVFERDMNSVILHFFFCGCAYFTFGSLQFSIMKFVGDNTTYRVRKQYISRLLRKDARY 150
Query: 416 YDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLS 595
+D ++G LS L DNLER RE +K+ L F G A+AF DW L + S
Sbjct: 151 FDSMSTGHLSTILNDNLERFREVFNEKIALIIAFATDFTVGTALAFYTDWRLASYGIVFS 210
Query: 596 PFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALE 775
+ GL YA AG IA + L + +TV + NGQ E +RY L+
Sbjct: 211 LGIAFSGLINSASMMKNTDKQNAHYANAGSIAFQ-LGAYKTVCSLNGQRQEIERYTKELK 269
Query: 776 HGKKTGIKKS--FLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMM 949
G+K G+ ++ + I G+ FF + L F G N +Y G L++GTV
Sbjct: 270 EGEKYGLYRALFYSISRGVTYFFCNALNTVVLYF--GANMIYDGTLDTGTV--------- 318
Query: 950 GSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFT 1129
+ EI+ + + + G IS V+F+
Sbjct: 319 ----------------------------VRDDNEIERDEEDCEDGVDVQGNISFKDVKFS 350
Query: 1130 YPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIED 1309
YP R D ++LKG+S D + G+ +ALVG+SG GKST++QLL +YN ++G ILID + +
Sbjct: 351 YPIRPDAQVLKGISFDVKNGECIALVGASGSGKSTVVQLLLHYYNIESGNILIDGVELNK 410
Query: 1310 FNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEGL 1489
N+K LR+++GVVSQEP LFNT+IE+NIR+G S+ + +I AL++ANA DF+ FP+G+
Sbjct: 411 INLKKLRRVIGVVSQEPVLFNTTIEENIRFGNSEATLPEIYGALRKANAYDFVCAFPKGI 470
Query: 1490 NTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGR 1669
T+VG+RG Q+SGGQKQRIAIAR LVRNPKILLLDEATSALD ESE +VQ ALENAS+GR
Sbjct: 471 KTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEHVVQKALENASQGR 530
Query: 1670 TTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVDDKPKK 1849
TTIV+AHRLST+RNA+KIIVM+ G+++EVG H+ LI ++G Y++LV AQ+ DD +
Sbjct: 531 TTIVVAHRLSTIRNANKIIVMQKGEIVEVGNHDELISKQGAYNDLVQAQLLNSHDDHNEL 590
Query: 1850 KEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXGAVKAN 2029
R S +F+ S GA K+N
Sbjct: 591 PPLTARQLSHELSPLHSYSFQRSTS---------TDAGVHDDDMERLLDELTQEGAKKSN 641
Query: 2030 LFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHFWAL 2209
L +I++ RP++ IQG P + + ++ D + GHFWAL
Sbjct: 642 LREIVKMCRPDYCILFLAVFGSAIQGISYPILAQLIVRTYQGYAMHGEDILTY-GHFWAL 700
Query: 2210 MFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTR 2389
F+ LA + ++ Q FG AE+L+ R+R K ++++L + ++D PKHS +++ R
Sbjct: 701 SFMFLAVFRPLTLYLQYYYFGKVAEKLSTRLRVKSFKHMLSLPSAFYDDPKHSATKLSNR 760
Query: 2390 LATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMK 2569
L TD+ N+K+A+D RLG + + ++ + A Y W+M V+ FP + + +
Sbjct: 761 LNTDSSNVKAAVDDRLGCVIMTLVAISIAVITAANYCWKMTLEVLMFFPLLYLAEYCYEA 820
Query: 2570 YHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAII 2749
+ D+ EN+ +TA+EA+EN+RTV+AL L+ K+ + +HL H +AII
Sbjct: 821 ATENAIQEDSIAFENSNRTAIEALENVRTVRALNLEDKVMSSITNHLQKIHNSYFKRAII 880
Query: 2750 RGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYF 2929
+G G + S F Y+ +F+FG++L K V EP N VL +S + G AA+Y
Sbjct: 881 QGAANGLSMSCFLFVYSISFKFGVYLALRKEV--EPMNTYLVLMTLSMTANMAGSAAAYL 938
Query: 2930 PEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVFFRYPERPAVPILQGL 3109
P+Y KA AAGLIFNM + +S G GE+ + F Y +RP IL G+
Sbjct: 939 PDYKKAVHAAGLIFNMFTYPATMPYDSSDGRKNIEKGEIVGENLQFHYDQRPDRMILNGV 998
Query: 3110 NVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALV 3289
N+ V+PG+TLALVGPSGCGKST+ISLLER Y G + +D ++ +N HLR +IALV
Sbjct: 999 NLKVEPGKTLALVGPSGCGKSTIISLLERFYHVTNGEIKIDRENVEDINLHHLRANIALV 1058
Query: 3290 SQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQL 3469
SQEP LF+ SIREN++YGL + +IE A AN F+ + P G +T VGE+G QL
Sbjct: 1059 SQEPTLFNCSIRENLLYGLTR-QVPQLEIEKALQTANAFHFVYQFPQGLDTIVGERGAQL 1117
Query: 3470 SGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLST 3649
SGGQKQRIAIARA++RNPK+LLLDEATSALD++SEK VQ ALD A++ + +VVAHRLST
Sbjct: 1118 SGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLST 1177
Query: 3650 IVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQ 3763
+VNA I V+KNG+V EQGTH EL+ R Y+ L QKQ
Sbjct: 1178 VVNADSIAVLKNGKVAEQGTHEELLRLRSVYWGLVQKQ 1215
Score = 269 bits (688), Expect = 3e-70
Identities = 200/583 (34%), Positives = 280/583 (47%), Gaps = 24/583 (4%)
Frame = +2
Query: 2096 LIQGAVMPAFSLFFSQ-------IINVFSNPDRDQ---------MKKDGHFWALMFLVLA 2227
L+ G P S F + I N +N D ++D + L F
Sbjct: 51 LLTGLCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEKAYEVFERDMNSVILHFFFCG 110
Query: 2228 AVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAP 2407
T Q S+ + T R+R + +LR+DA YFD S G ++T L +
Sbjct: 111 CAYFTFGSLQFSIMKFVGDNTTYRVRKQYISRLLRKDARYFD--SMSTGHLSTILNDNLE 168
Query: 2408 NIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMA----VGQALMMKYH 2575
+ + ++ I G +AFY W++A + +A + A MMK
Sbjct: 169 RFREVFNEKIALIIAFATDFTVGTALAFYTDWRLASYGIVFSLGIAFSGLINSASMMK-- 226
Query: 2576 GGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAII-- 2749
+ NAG A + + +TV +L Q + + L + +A+
Sbjct: 227 --NTDKQNAHYANAGSIAFQ-LGAYKTVCSLNGQRQEIERYTKELKEGEKYGLYRALFYS 283
Query: 2750 --RGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAAS 2923
RG+TY F N++ FG +I+D
Sbjct: 284 ISRGVTYFFCNALN----TVVLYFGANMIYD----------------------------- 310
Query: 2924 YFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVFFRYPERPAVPILQ 3103
T G + E R + G + G + V F YP RP +L+
Sbjct: 311 -------GTLDTGTVVRDDNEIERDEEDCEDGV--DVQGNISFKDVKFSYPIRPDAQVLK 361
Query: 3104 GLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIA 3283
G++ VK G+ +ALVG SG GKSTV+ LL Y+ G + +D +L ++N K LR+ I
Sbjct: 362 GISFDVKNGECIALVGASGSGKSTVVQLLLHYYNIESGNILIDGVELNKINLKKLRRVIG 421
Query: 3284 LVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGT 3463
+VSQEP+LF+T+I ENI +G E T +I A KAN + F+ P G +T VGE+GT
Sbjct: 422 VVSQEPVLFNTTIEENIRFG--NSEATLPEIYGALRKANAYDFVCAFPKGIKTIVGERGT 479
Query: 3464 QLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRL 3643
QLSGGQKQRIAIAR L+RNPKILLLDEATSALD ESE VQ AL+ A++ RT IVVAHRL
Sbjct: 480 QLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEHVVQKALENASQGRTTIVVAHRL 539
Query: 3644 STIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSSN 3772
STI NA I+V++ G++VE G H+ELI+K+GAY L Q Q N
Sbjct: 540 STIRNANKIIVMQKGEIVEVGNHDELISKQGAYNDLVQAQLLN 582
>gi|17569907|ref|NP_509813.1| P-GlycoProtein related (pgp-6)
[Caenorhabditis elegans]
gi|6425208|emb|CAA94220.2| Hypothetical protein T21E8.1
[Caenorhabditis elegans]
Length = 1225
Score = 862 bits (2226), Expect = 0.0
Identities = 490/1237 (39%), Positives = 709/1237 (56%), Gaps = 1/1237 (0%)
Frame = +2
Query: 56 LYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAA 235
+++ +S ++ + +G++ S TG P MS G VSQ VT+ + ++
Sbjct: 31 VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEK 90
Query: 236 ARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAW 415
A E+ + Q + GC F LQ + + + + R R+Q+ +++++ +
Sbjct: 91 AYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQY 150
Query: 416 YDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLS 595
+D ++G LS L DNLER RE +K+ L + F G A+AF DW L + S
Sbjct: 151 FDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFS 210
Query: 596 PFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALE 775
+ G YA AG IA + L + +TV + NGQ+ E +RY + L+
Sbjct: 211 LGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELK 270
Query: 776 HGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGS 955
G+K GI+++ + + + + +VG +YSG LE+ V+
Sbjct: 271 AGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYSGTLETAVVVRD-------- 322
Query: 956 MALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYP 1135
D + E D T+ +++G IS V+F+YP
Sbjct: 323 ---------------------------DNVIEKD--ETDYDVEVEVNGNISFKNVKFSYP 353
Query: 1136 TRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFN 1315
TR D ++LKG+S D Q G+ +ALVG+SG GKST++QLL +YN D+G I ID + + D N
Sbjct: 354 TRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMN 413
Query: 1316 IKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEGLNT 1495
IK LR+++GVVSQEP LFNT+IE+NIR+G +VS +I AL++ANA DF+ +FP+G+ T
Sbjct: 414 IKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKT 473
Query: 1496 LVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTT 1675
+VG+RG Q+SGGQKQRIAIAR LVRNPKILLLDEATSALD ESE +VQ ALENAS+GRTT
Sbjct: 474 IVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTT 533
Query: 1676 IVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVDDKPKKKE 1855
IV+AHRLST+RNA KIIVM+ G+++EVG H+ LI ++G+Y++LV AQ+ DD +E
Sbjct: 534 IVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLESHDDH---EE 590
Query: 1856 AERRMSRQTSQRKGSVN-FKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXGAVKANL 2032
+RQ SQ ++ + Q S GA K+NL
Sbjct: 591 LPPLAARQLSQELSPLHSYAIQRS-------TSNDAGVHDDDMERILDELSKEGAKKSNL 643
Query: 2033 FKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHFWALM 2212
+I++ RP++ + IQG P + + F+ D + H WAL
Sbjct: 644 REIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYYS-HLWALS 702
Query: 2213 FLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRL 2392
F+ LA + ++ Q FG +E+L+ R+R K + ++L ++D P HS R++ RL
Sbjct: 703 FMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRL 762
Query: 2393 ATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKY 2572
TD+ N+K+A+D RLG + + ++ + A Y W+M V+ FP + + +
Sbjct: 763 NTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPLLYLAEYCYEAA 822
Query: 2573 HGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIR 2752
+ D EN+ +TA+EA+EN+RTV+AL L+ K+ ++ HL H +AII+
Sbjct: 823 TETAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQ 882
Query: 2753 GLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFP 2932
G G + S F Y+ +F+FG +L K V P + VL +S + G AA+Y P
Sbjct: 883 GAANGLSLSCFLFVYSVSFKFGTYLALRKEVA--PMDTYLVLMTLSMTANMAGSAAAYLP 940
Query: 2933 EYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVFFRYPERPAVPILQGLN 3112
+Y KA AAGLIF++ + +S G GE+ V F Y +RP IL G+N
Sbjct: 941 DYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVN 1000
Query: 3113 VHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVS 3292
+ V PG+TLALVGPSGCGKST+ISLLER Y ++G V +D+ ++ +N HLR ++ALVS
Sbjct: 1001 LKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVS 1060
Query: 3293 QEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLS 3472
QEP LF+ SIREN++YGL ++E A AN F+ + P G +T VGE+G QLS
Sbjct: 1061 QEPTLFNCSIRENLLYGLTRS-VPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLS 1119
Query: 3473 GGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTI 3652
GGQKQRIAIARA++RNPK+LLLDEATSALD++SEK VQ ALD A++ + +VVAHRLST+
Sbjct: 1120 GGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTV 1179
Query: 3653 VNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQ 3763
VNA I V+KNG+V EQGTH EL+ KR Y+ L QKQ
Sbjct: 1180 VNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 1216
>gi|31213429|ref|XP_315658.1| ENSANGP00000021663 [Anopheles gambiae]
gi|21299609|gb|EAA11754.1| ENSANGP00000021663 [Anopheles gambiae str.
PEST]
Length = 1243
Score = 860 bits (2221), Expect = 0.0
Identities = 497/1270 (39%), Positives = 713/1270 (56%), Gaps = 35/1270 (2%)
Frame = +2
Query: 59 YRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFV--TLG----------TIF- 199
+R+ + + +G++++ +GLP I+ G + V T+G +IF
Sbjct: 1 FRFATWGEVCATLMGVLLASMASLGLPYGVILYGEFTTLLVDRTIGIGKSTDTAILSIFG 60
Query: 200 ---LDPNSTASEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQ-------ASCFMVIC 349
+ N+T E AAA E + G G+ A LQ
Sbjct: 61 GGRVLVNATEQENAAAIMEDAKA----------FGLGVVAVTILQFIFATLSVDVINRSA 110
Query: 350 EKLSNRFRRQFFHSVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQF 529
+K +R R+ F +V+RQ++ WYD N+ + + ++ D+L++++EG G+K+ + ++ F
Sbjct: 111 QKQISRIRQLFLKAVLRQDMTWYDLNSDDSFAVRITDDLDKLKEGIGEKLSIFTYLVMSF 170
Query: 530 IGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTS 709
+ +F Y W LTL+++S +P +++ F Y+ AG +AEEVL S
Sbjct: 171 VISVIFSFFYGWKLTLVILSCAPIIILATAFVAKMQSTLTEKELKSYSSAGAVAEEVLGS 230
Query: 710 IRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNF 889
IRTV+AF G++ E RY + L + G +K G G + IIY Y LAFW G +
Sbjct: 231 IRTVVAFGGEKKEADRYRERLAGAELNGRRKGLFSGIGGGIMWFIIYCCYALAFWYGISL 290
Query: 890 VYSGRLES------GTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPE 1051
+ R + ++ V F V+ G+ LG + TA G+AA+++ VIDRIP
Sbjct: 291 ILEDRDKDLKDYTPAVLIIVLFGVLAGAQNLGLSSPHLEAFSTAKGSAATIFSVIDRIPV 350
Query: 1052 IDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKS 1231
ID+ G P + G I + V F YP R DV++L+G++L+ + GQTVALVG SGCGKS
Sbjct: 351 IDSLGDAGLRPGSMQGNIKFSNVFFRYPARNDVQVLQGLNLEIKTGQTVALVGPSGCGKS 410
Query: 1232 TIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSD 1411
T +QL+QR Y+P +G + ID + + NI +LR +G+V QEP LF T+I +NIRYG D
Sbjct: 411 TCLQLIQRLYDPLSGSVTIDGTKVSELNIGWLRSFIGLVGQEPVLFATTIAENIRYGNPD 470
Query: 1412 VSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLL 1591
S +I RA K AN FI P G T++G+RG Q+SGGQKQRIAIARALVRNPKILLL
Sbjct: 471 ASQSEIERAAKIANCHSFITKLPNGYATMIGERGAQLSGGQKQRIAIARALVRNPKILLL 530
Query: 1592 DEATSALDAESESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHET 1771
DEATSALD SE VQ ALE AS+GRTT+V++HRLST+ NADKI+ + G VME GTHE
Sbjct: 531 DEATSALDPNSEKRVQDALERASKGRTTLVVSHRLSTITNADKIVYIDKGLVMEQGTHEE 590
Query: 1772 LIEQKGLYHELVHAQ-VFADVDDKPKKKEAERRMS-RQTSQRKGSVNFKTQESQVDXXXX 1945
L+ +GLY++LV A VDD A +S RQ S G+ + + + D
Sbjct: 591 LMAARGLYYDLVVASGSQKTVDDDESVPMAPSALSMRQESVDDGA---EASDDESDSGKS 647
Query: 1946 XXXXXXXXXXXXXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAF 2125
+L ++L+ PEW Y ++ GA PAF
Sbjct: 648 DEKNEEEQEE-------------VYHVSLMRLLKLNAPEWHYILFGCAAAIVVGASFPAF 694
Query: 2126 SLFFSQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIR 2305
++ F ++ + S D + +K++ +F++ +FLVL + G FQ LF +A RLT R+R
Sbjct: 695 AVLFGEMYGILSVADPEYVKEESNFYSFLFLVLGLITGVGTFFQTYLFNIAGVRLTSRLR 754
Query: 2306 SKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGI 2485
K ++ ++ QD +FD +++ G + RL+ D +++ A R+GS+ A +++ G+GI
Sbjct: 755 QKSFKAIVSQDMAWFDESRNAVGALCARLSGDCASVQGATGTRIGSLLQAASTICIGVGI 814
Query: 2486 AFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQA 2665
+F+Y W + + + P L +Y S+ + + E A K A+EAI NIRTV +
Sbjct: 815 SFFYSWNLTLVSIIAIPVTLASITLESRYSQTSSLKEKQSQEGATKLAVEAISNIRTVAS 874
Query: 2666 LTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNV 2845
L + + + K +RG + + F Y A +G L+ +K
Sbjct: 875 LGQEKHVLQRYGEETVKIDDACRRKTRLRGTVFALGQVMPFAGYGLALFYGGKLVSEKE- 933
Query: 2846 LMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTY 3025
+E ++V++V A+ F +G A +Y P A +AG + +L+ PR+ ++S Y
Sbjct: 934 -LEYKDVIKVSEALIFGAWMLGQALAYAPNVNSAILSAGRLMKLLDRTPRMHNPSTS--Y 990
Query: 3026 PQLS----GEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLE 3193
LS G++K V FRYP RP VP+LQGLN+ + GQT+ALVGPSGCGKST I LL
Sbjct: 991 HSLSQRTEGDIKFTDVEFRYPTRPTVPVLQGLNLDIGKGQTVALVGPSGCGKSTCIQLLL 1050
Query: 3194 RLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQ 3373
R YDP G V +D + + +R + LVSQEPILFD +I ENI YG E +
Sbjct: 1051 RYYDPDSGKVDIDGTTTTEFSLNRIRAQMGLVSQEPILFDRTIAENIAYGDNTREIAMPE 1110
Query: 3374 IETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATS 3553
I A ANIH+FI LP GY+T +G KG QLSGGQKQRIAIARAL+RNP++LLLDEATS
Sbjct: 1111 IMEAAKMANIHEFIVNLPKGYDTSLGSKGAQLSGGQKQRIAIARALVRNPRVLLLDEATS 1170
Query: 3554 ALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKR 3733
ALD +SEK VQ ALD A RTCI++AHRL+TI NA I V++NG VVE GTH+EL+AK
Sbjct: 1171 ALDNQSEKIVQNALDHARTGRTCIIIAHRLTTIQNANLICVIQNGVVVEAGTHDELMAKS 1230
Query: 3734 GAYFALTQKQ 3763
Y L Q Q
Sbjct: 1231 RIYAKLYQMQ 1240
Score = 368 bits (945), Expect = e-100
Identities = 213/550 (38%), Positives = 313/550 (56%), Gaps = 5/550 (0%)
Frame = +2
Query: 2144 IINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRN 2323
++N + + +D + L + + +Q + +A++ RIR +
Sbjct: 65 LVNATEQENAAAIMEDAKAFGLGVVAVTILQFIFATLSVDVINRSAQKQISRIRQLFLKA 124
Query: 2324 VLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGW 2503
VLRQD T++D+ +S R+ D +K I +L + S + +F+YGW
Sbjct: 125 VLRQDMTWYDL--NSDDSFAVRITDDLDKLKEGIGEKLSIFTYLVMSFVISVIFSFFYGW 182
Query: 2504 QMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTK 2683
++ ++++ P + + A + K + K +AG A E + +IRTV A + K
Sbjct: 183 KLTLVILSCAPIIILATAFVAKMQSTLTEKELKSYSSAGAVAEEVLGSIRTVVAFGGEKK 242
Query: 2684 LYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIF---DKNVL-M 2851
+ + L K + G+ G I + YA AF +G+ LI DK++
Sbjct: 243 EADRYRERLAGAELNGRRKGLFSGIGGGIMWFIIYCCYALAFWYGISLILEDRDKDLKDY 302
Query: 2852 EPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYP- 3028
P ++ VLF + +G ++ + + A +A IF++++ P ID + +G P
Sbjct: 303 TPAVLIIVLFGVLAGAQNLGLSSPHLEAFSTAKGSAATIFSVIDRIPVIDSLGDAGLRPG 362
Query: 3029 QLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDP 3208
+ G +K + VFFRYP R V +LQGLN+ +K GQT+ALVGPSGCGKST + L++RLYDP
Sbjct: 363 SMQGNIKFSNVFFRYPARNDVQVLQGLNLEIKTGQTVALVGPSGCGKSTCLQLIQRLYDP 422
Query: 3209 LEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETAC 3388
L G+VT+D + ++N LR I LV QEP+LF T+I ENI YG + + +IE A
Sbjct: 423 LSGSVTIDGTKVSELNIGWLRSFIGLVGQEPVLFATTIAENIRYGNP--DASQSEIERAA 480
Query: 3389 SKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTE 3568
AN H FI +LP+GY T +GE+G QLSGGQKQRIAIARAL+RNPKILLLDEATSALD
Sbjct: 481 KIANCHSFITKLPNGYATMIGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDPN 540
Query: 3569 SEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFA 3748
SEK+VQ AL+ A+K RT +VV+HRLSTI NA I+ + G V+EQGTH EL+A RG Y+
Sbjct: 541 SEKRVQDALERASKGRTTLVVSHRLSTITNADKIVYIDKGLVMEQGTHEELMAARGLYYD 600
Query: 3749 LTQKQSSNQS 3778
L S ++
Sbjct: 601 LVVASGSQKT 610
Score = 337 bits (863), Expect = 2e-90
Identities = 199/526 (37%), Positives = 305/526 (57%), Gaps = 7/526 (1%)
Frame = +2
Query: 269 NCLKYVYLGCGIFAA--GFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYD--KNTSG 436
N +++L G+ F Q F + +L++R R++ F +++ Q++AW+D +N G
Sbjct: 718 NFYSFLFLVLGLITGVGTFFQTYLFNIAGVRLTSRLRQKSFKAIVSQDMAWFDESRNAVG 777
Query: 437 TLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICG 616
L +L + V+ TG ++G Q + G ++F Y W LTL+ + P +
Sbjct: 778 ALCARLSGDCASVQGATGTRIGSLLQAASTICIGVGISFFYSWNLTLVSIIAIPVTLASI 837
Query: 617 LFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGI 796
A +A E +++IRTV + +++ +RY +
Sbjct: 838 TLESRYSQTSSLKEKQSQEGATKLAVEAISNIRTVASLGQEKHVLQRYGEETVKIDDACR 897
Query: 797 KKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAG 976
+K+ L G A V+ +A Y LA + G V LE V+ V +++ G+ LGQA
Sbjct: 898 RKTRLRGTVFALGQVMPFAGYGLALFYGGKLVSEKELEYKDVIKVSEALIFGAWMLGQAL 957
Query: 977 QQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPS-KISGRISVNKVEFTYPTRADVK 1153
+ +A+ +A L +++DR P + ST + S + G I VEF YPTR V
Sbjct: 958 AYAPNVNSAILSAGRLMKLLDRTPRMHNPSTSYHSLSQRTEGDIKFTDVEFRYPTRPTVP 1017
Query: 1154 ILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQ 1333
+L+G++LD GQTVALVG SGCGKST IQLL R+Y+PD+G++ ID +F++ +R
Sbjct: 1018 VLQGLNLDIGKGQTVALVGPSGCGKSTCIQLLLRYYDPDSGKVDIDGTTTTEFSLNRIRA 1077
Query: 1334 LVGVVSQEPNLFNTSIEQNIRYGRS--DVSDEDIARALKEANAADFIKTFPEGLNTLVGD 1507
+G+VSQEP LF+ +I +NI YG + +++ +I A K AN +FI P+G +T +G
Sbjct: 1078 QMGLVSQEPILFDRTIAENIAYGDNTREIAMPEIMEAAKMANIHEFIVNLPKGYDTSLGS 1137
Query: 1508 RGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIA 1687
+G Q+SGGQKQRIAIARALVRNP++LLLDEATSALD +SE IVQ+AL++A GRT I+IA
Sbjct: 1138 KGAQLSGGQKQRIAIARALVRNPRVLLLDEATSALDNQSEKIVQNALDHARTGRTCIIIA 1197
Query: 1688 HRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFA 1825
HRL+T++NA+ I V++ G V+E GTH+ L+ + +Y +L Q A
Sbjct: 1198 HRLTTIQNANLICVIQNGVVVEAGTHDELMAKSRIYAKLYQMQQVA 1243
>gi|15226477|ref|NP_182223.1| multidrug resistant (MDR) ABC
transporter, putative [Arabidopsis thaliana]
gi|7442647|pir||T02187 probable ABC transporter [imported] -
Arabidopsis thaliana
gi|3522943|gb|AAC34225.1| putative ABC transporter [Arabidopsis
thaliana]
Length = 1286
Score = 859 bits (2220), Expect = 0.0
Identities = 482/1255 (38%), Positives = 725/1255 (57%), Gaps = 16/1255 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+ ++L+ + + D L++ +G + S G+G PLM+++ G++ F N T
Sbjct: 46 VPFYKLFAFADSFDFLLMILGTLGSIGNGLGFPLMTLLFGDLIDAF--------GENQTN 97
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
+ + +V + LK+V+LG G FAA FLQ S +M+ E+ + R R + +++R
Sbjct: 98 T---------TDKVSKVALKFVWLGIGTFAAAFLQLSGWMISGERQAARIRSLYLKTILR 148
Query: 401 QEIAWYDKNTS-GTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
Q+IA++D +T+ G + ++ + +++ G+KVG A Q++A F+GGF +AF WLLTL
Sbjct: 149 QDIAFFDIDTNTGEVVGRMSGDTVLIQDAMGEKVGKAIQLLATFVGGFVIAFVRGWLLTL 208
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
+M+S P +++ G YA A + E+ + SIRTV +F G++
Sbjct: 209 VMLSSIPLLVMAGALLAIVIAKTASRGQTAYAKAATVVEQTIGSIRTVASFTGEKQAISN 268
Query: 758 YEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFF 937
Y L K G+ + G GL + F++++ SY LA W G + G VL +
Sbjct: 269 YNKHLVTAYKAGVIEGGSTGLGLGTLFLVVFCSYALAVWYGGKLILDKGYTGGQVLNIII 328
Query: 938 SVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNK 1117
+V+ GSM+LGQ + AA ++E I+R P ID+YST G+ I G I +
Sbjct: 329 AVLTGSMSLGQTSPCLSAFAAGQAAAYKMFETIERRPNIDSYSTNGKVLDDIKGDIELKD 388
Query: 1118 VEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDI 1297
V FTYP R D +I +G SL G TVALVG SG GKST++ L++RFY+P AG +LID I
Sbjct: 389 VYFTYPARPDEQIFRGFSLFISSGTTVALVGQSGSGKSTVVSLIERFYDPQAGDVLIDGI 448
Query: 1298 PIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTF 1477
+++F +K++R +G+VSQEP LF SI+ NI YG+ D + E+I A + ANA+ F+
Sbjct: 449 NLKEFQLKWIRSKIGLVSQEPVLFTASIKDNIAYGKEDATTEEIKAAAELANASKFVDKL 508
Query: 1478 PEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENA 1657
P+GL+T+VG+ G Q+SGGQKQRIA+ARA++++P+ILLLDEATSALDAESE +VQ AL+
Sbjct: 509 PQGLDTMVGEHGTQLSGGQKQRIAVARAILKDPRILLLDEATSALDAESERVVQEALDRI 568
Query: 1658 SRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTH-ETLIEQKGLYHELVHAQVFADVD 1834
RTT+V+AHRLSTVRNAD I V+ G+++E G+H E L + +G Y +L+ Q D
Sbjct: 569 MVNRTTVVVAHRLSTVRNADMIAVIHQGKIVEKGSHTELLKDPEGAYSQLIRLQEEKKSD 628
Query: 1835 DK--PKKKEAERRMSRQTSQRK----------GSVNFKTQESQVDXXXXXXXXXXXXXXX 1978
+ ++K + +Q+S RK GS + +
Sbjct: 629 ENAAEEQKMSSIESFKQSSLRKSSLGRSLSKGGSSRGNSSRHSFNMFGFPAGIDGNVVQD 688
Query: 1979 XXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVF 2158
K ++F+I +PE G ++P F + S +I F
Sbjct: 689 QEEDDTTQPKTEPKKVSIFRIAALNKPEIPVLILGSISAAANGVILPIFGILISSVIKAF 748
Query: 2159 SNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQD 2338
P + ++K+D FWA++F+VL + Q F +A +L RIRS + V+ +
Sbjct: 749 FQPPK-KLKEDTSFWAIIFMVLGFASIIAYPAQTFFFAIAGCKLVQRIRSMCFEKVVHME 807
Query: 2339 ATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFL 2518
+FD P++S G I RL+ DA I+ + L ++S+ GL IAF WQ+AF+
Sbjct: 808 VGWFDEPENSSGTIGARLSADAATIRGLVGDSLAQTVQNLSSILAGLIIAFLACWQLAFV 867
Query: 2519 VMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIF 2698
V+A+ P +A+ L MK+ G + K A + A +A+ +IRTV + + K+ N++
Sbjct: 868 VLAMLPLIALNGFLYMKFMKGFSADAKKMYGEASQVANDAVGSIRTVASFCAEDKVMNMY 927
Query: 2699 CSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVL 2878
+ P I + I+ G+ +GF+ + F +YAA+F G L+ D ++V RV
Sbjct: 928 SKKCEGPMKNGIRQGIVSGIGFGFSFFVLFSSYAASFYVGARLVDDGKTTF--DSVFRVF 985
Query: 2879 FAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSG-TYPQLSGEVKLN 3055
FA++ + I ++S P+ KA AA IF +++ E +ID SG + G+++L
Sbjct: 986 FALTMAAMAISQSSSLSPDSSKADVAAASIFAIMDRESKIDPSVESGRVLDNVKGDIELR 1045
Query: 3056 KVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDN 3235
V F+YP RP V I Q L + ++ G+T+ALVG SG GKSTVI+LL+R YDP G +T+D
Sbjct: 1046 HVSFKYPARPDVQIFQDLCLSIRAGKTVALVGESGSGKSTVIALLQRFYDPDSGEITLDG 1105
Query: 3236 NDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFI 3415
+++ + K LR+ LVSQEPILF+ +IR NI YG + G+ + +I ++ +N H FI
Sbjct: 1106 VEIKSLRLKWLRQQTGLVSQEPILFNETIRANIAYG-KGGDASESEIVSSAELSNAHGFI 1164
Query: 3416 DELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVAL 3595
L GY+T VGE+G QLSGGQKQR+AIARA++++PK+LLLDEATSALD ESE+ VQ AL
Sbjct: 1165 SGLQQGYDTMVGERGIQLSGGQKQRVAIARAIVKDPKVLLLDEATSALDAESERVVQDAL 1224
Query: 3596 DAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELI-AKRGAYFALTQ 3757
D +RT IVVAHRLSTI NA I VVKNG +VE+G H+ LI K G Y +L Q
Sbjct: 1225 DRVMVNRTTIVVAHRLSTIKNADVIAVVKNGVIVEKGKHDTLINIKDGVYASLVQ 1279
Score = 384 bits (985), Expect = e-104
Identities = 219/583 (37%), Positives = 327/583 (55%), Gaps = 4/583 (0%)
Frame = +2
Query: 89 MLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHEVIQ 268
+L +G I + A GV LP+ I++ +V + F P E + A
Sbjct: 719 VLILGSISAAANGVILPIFGILISSVIK-------AFFQPPKKLKEDTSFWA-------- 763
Query: 269 NCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYDK--NTSGTL 442
+ ++ LG A Q F + KL R R F V+ E+ W+D+ N+SGT+
Sbjct: 764 --IIFMVLGFASIIAYPAQTFFFAIAGCKLVQRIRSMCFEKVVHMEVGWFDEPENSSGTI 821
Query: 443 SNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLF 622
+L + +R GD + Q ++ + G +AF W L +++++ P + + G
Sbjct: 822 GARLSADAATIRGLVGDSLAQTVQNLSSILAGLIIAFLACWQLAFVVLAMLPLIALNGFL 881
Query: 623 XXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKK 802
Y A +A + + SIRTV +F ++ Y E K GI++
Sbjct: 882 YMKFMKGFSADAKKMYGEASQVANDAVGSIRTVASFCAEDKVMNMYSKKCEGPMKNGIRQ 941
Query: 803 SFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQ 982
+ G G F ++++SY +F+VG V G+ +V VFF++ M +MA+ Q+
Sbjct: 942 GIVSGIGFGFSFFVLFSSYAASFYVGARLVDDGKTTFDSVFRVFFALTMAAMAISQSSSL 1001
Query: 983 FATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILK 1162
A AAAS++ ++DR +ID G+ + G I + V F YP R DV+I +
Sbjct: 1002 SPDSSKADVAAASIFAIMDRESKIDPSVESGRVLDNVKGDIELRHVSFKYPARPDVQIFQ 1061
Query: 1163 GVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVG 1342
+ L + G+TVALVG SG GKST+I LLQRFY+PD+G+I +D + I+ +K+LRQ G
Sbjct: 1062 DLCLSIRAGKTVALVGESGSGKSTVIALLQRFYDPDSGEITLDGVEIKSLRLKWLRQQTG 1121
Query: 1343 VVSQEPNLFNTSIEQNIRYGR-SDVSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQ 1519
+VSQEP LFN +I NI YG+ D S+ +I + + +NA FI +G +T+VG+RG+Q
Sbjct: 1122 LVSQEPILFNETIRANIAYGKGGDASESEIVSSAELSNAHGFISGLQQGYDTMVGERGIQ 1181
Query: 1520 MSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLS 1699
+SGGQKQR+AIARA+V++PK+LLLDEATSALDAESE +VQ AL+ RTTIV+AHRLS
Sbjct: 1182 LSGGQKQRVAIARAIVKDPKVLLLDEATSALDAESERVVQDALDRVMVNRTTIVVAHRLS 1241
Query: 1700 TVRNADKIIVMKAGQVMEVGTHETLIEQK-GLYHELVHAQVFA 1825
T++NAD I V+K G ++E G H+TLI K G+Y LV + A
Sbjct: 1242 TIKNADVIAVVKNGVIVEKGKHDTLINIKDGVYASLVQLHLTA 1284
Score = 347 bits (889), Expect = 2e-93
Identities = 207/560 (36%), Positives = 311/560 (54%), Gaps = 2/560 (0%)
Frame = +2
Query: 2105 GAVMPAFSLFFSQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAE 2284
G P +L F +I+ F + K AL F+ L + Q S + ++ E
Sbjct: 74 GLGFPLMTLLFGDLIDAFGENQTNTTDKVSKV-ALKFVWLGIGTFAAAFLQLSGWMISGE 132
Query: 2285 RLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIAS 2464
R RIRS + +LRQD +FD+ ++ G + R++ D I+ A+ ++G +A+
Sbjct: 133 RQAARIRSLYLKTILRQDIAFFDIDTNT-GEVVGRMSGDTVLIQDAMGEKVGKAIQLLAT 191
Query: 2465 VGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIE 2644
GG IAF GW + ++++ P + + AL+ +A+ A + I
Sbjct: 192 FVGGFVIAFVRGWLLTLVMLSSIPLLVMAGALLAIVIAKTASRGQTAYAKAATVVEQTIG 251
Query: 2645 NIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLF 2824
+IRTV + T + + + + HL + + + GL G + F +YA A +G
Sbjct: 252 SIRTVASFTGEKQAISNYNKHLVTAYKAGVIEGGSTGLGLGTLFLVVFCSYALAVWYGGK 311
Query: 2825 LIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDG 3004
LI DK VL ++ A+ ++G + + AA +F +E P ID
Sbjct: 312 LILDKGYT--GGQVLNIIIAVLTGSMSLGQTSPCLSAFAAGQAAAYKMFETIERRPNIDS 369
Query: 3005 MTSSG-TYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVI 3181
+++G + G+++L V+F YP RP I +G ++ + G T+ALVG SG GKSTV+
Sbjct: 370 YSTNGKVLDDIKGDIELKDVYFTYPARPDEQIFRGFSLFISSGTTVALVGQSGSGKSTVV 429
Query: 3182 SLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEY 3361
SL+ER YDP G V +D +L++ K +R I LVSQEP+LF SI++NI YG + +
Sbjct: 430 SLIERFYDPQAGDVLIDGINLKEFQLKWIRSKIGLVSQEPVLFTASIKDNIAYGKE--DA 487
Query: 3362 THEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLD 3541
T E+I+ A AN KF+D+LP G +T VGE GTQLSGGQKQRIA+ARA++++P+ILLLD
Sbjct: 488 TTEEIKAAAELANASKFVDKLPQGLDTMVGEHGTQLSGGQKQRIAVARAILKDPRILLLD 547
Query: 3542 EATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNEL 3721
EATSALD ESE+ VQ ALD +RT +VVAHRLST+ NA I V+ G++VE+G+H EL
Sbjct: 548 EATSALDAESERVVQEALDRIMVNRTTVVVAHRLSTVRNADMIAVIHQGKIVEKGSHTEL 607
Query: 3722 IA-KRGAYFALTQKQSSNQS 3778
+ GAY L + Q +S
Sbjct: 608 LKDPEGAYSQLIRLQEEKKS 627
>gi|11038656|ref|NP_066302.1| ATP-binding cassette, sub-family B,
member 11; bile salt export pump; sister of
P-glycoprotein [Mus musculus]
gi|12643304|sp|Q9QY30|AB11_MOUSE Bile salt export pump (ATP-binding
cassette, sub-family B, member 11) (Sister of
P-glycoprotein)
gi|6502606|gb|AAF14372.1| liver bile salt export pump;
sister-of-p-glycoprotein [Mus musculus domesticus]
Length = 1321
Score = 858 bits (2218), Expect = 0.0
Identities = 493/1271 (38%), Positives = 732/1271 (56%), Gaps = 34/1271 (2%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTL----------G 190
+ F+L+R++S+ D ++ +G + + G+ P M I+ G ++ FV G
Sbjct: 45 VGFFELFRFSSSKDNWLMFMGSVCALLHGMAQPGMIIVFGILTDIFVEYDIERQELSIPG 104
Query: 191 TIFLDP-----NSTASEK-----AAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFM 340
+ ++ NS+ ++ + + + EVI+ Y +G + G+ Q ++
Sbjct: 105 KVCMNNTIVWINSSFNQNMTNGTSCGLVDINSEVIKFSGIYAGVGVAVLILGYFQIRLWV 164
Query: 341 VICEKLSNRFRRQFFHSVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMM 520
+ + + R+ +F +MR EI W+D + G L+++ D++ ++ E D++ L Q +
Sbjct: 165 ITGARQIRKMRKFYFRRIMRMEIGWFDCTSVGELNSRFSDDINKIDEAIADQMALFLQRL 224
Query: 521 AQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEV 700
+ + G + F W LTL+++++SP + I YA AG IA+EV
Sbjct: 225 STALSGLLLGFYRGWKLTLVILAVSPLIGIGAAVIGLSVAKFTELELKAYAKAGSIADEV 284
Query: 701 LTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVG 880
L+SIRTV AF G+ E +RYE L ++ GI K ++G + +I+ Y LAFW G
Sbjct: 285 LSSIRTVAAFGGENKEVERYEKNLMFAQRWGIWKGMVMGFFTGYMWCLIFFCYALAFWYG 344
Query: 881 TNFVYS-GRLESGTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEID 1057
+ V G GT++ +F V++ +M +G A T AA+S+++ IDR P +D
Sbjct: 345 SRLVLDEGEYTPGTLIQIFLCVIIAAMNIGNASSCLEIFSTGCSAASSIFQTIDRQPVMD 404
Query: 1058 AYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTI 1237
S +G +I G I + V F YP+R +VKIL +S+ +PG+T A VGSSG GKST
Sbjct: 405 CMSGDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNNLSMVIKPGETTAFVGSSGAGKSTA 464
Query: 1238 IQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVS 1417
+QL+QRFY+P G + +D I NI++LR +G+V QEP LF+T+I +NIR GR + +
Sbjct: 465 LQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAENIRLGREEAT 524
Query: 1418 DEDIARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDE 1597
EDI +A K+ANA +FI P+ +TLVG+ G QMSGGQKQR+AIARAL+R PKILLLD
Sbjct: 525 MEDIVQAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQKQRVAIARALIRKPKILLLDM 584
Query: 1598 ATSALDAESESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLI 1777
ATSALD ESE+ VQ AL G T I +AHRLSTVR+AD II + G +E GTHE L+
Sbjct: 585 ATSALDNESEAKVQGALNKIQHGHTIISVAHRLSTVRSADVIIGFEHGTAVERGTHEELL 644
Query: 1778 EQKGLYHELVHAQVFADVDDKP---KKKEA------ERRMSRQTSQR--KGSVNFKTQES 1924
E+KG+Y LV Q D K K K+ ER SR + Q + S+ +++
Sbjct: 645 ERKGVYFMLVTLQSQEDNTHKETGIKGKDTTEGDTPERTFSRGSYQDSLRASIRQRSKSQ 704
Query: 1925 QVDXXXXXXXXXXXXXXXXXXXXXXXXXXGAVK-ANLFKILRYARPEWIYXXXXXXXXLI 2101
V+ A + +IL+Y EW Y I
Sbjct: 705 LSHLSHEPPLAIGDHKSSYEDRKDNDVLVEEVEPAPVRRILKYNISEWPYILVGALCAAI 764
Query: 2102 QGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAA 2281
GAV P +SL FSQI+ FS D++Q + + + L F++L V + Q F +
Sbjct: 765 NGAVTPIYSLLFSQILKTFSLVDKEQQRSEIYSMCLFFVILGCVSLFTQFLQGYNFAKSG 824
Query: 2282 ERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIA 2461
E LT R+R ++ +LRQD +FD K++PG +TTRLATDA ++ A ++G + N+
Sbjct: 825 ELLTKRLRKFGFKAMLRQDIGWFDDLKNNPGVLTTRLATDASQVQGATGSQVGMMVNSFT 884
Query: 2462 SVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAI 2641
++ + IAF + W+++ ++ FPF+A+ A+ K G A+ D + +E AG+ EA+
Sbjct: 885 NIFVAVLIAFLFNWKLSLVISVFFPFLALSGAVQTKMLTGFASQDKEILEKAGQITNEAL 944
Query: 2642 ENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGL 2821
NIRTV + ++ + F L+ + I KA + GL Y F+ I F +AA+R+G
Sbjct: 945 SNIRTVAGIGVEGRFIKAFEVELEKSYKTAIRKANVYGLCYAFSQGISFLANSAAYRYGG 1004
Query: 2822 FLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRID 3001
+LI +++ V RV+ +I+ S +G SY P Y KA +A F +L+ +P ID
Sbjct: 1005 YLIVYEDLNFS--YVFRVVSSIAMSATAVGRTFSYTPSYAKAKISAARFFQLLDRKPPID 1062
Query: 3002 GMTSSGT-YPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTV 3178
+ +G + G++ F YP RP + +L GL+V V PGQTLA VG SGCGKST
Sbjct: 1063 VYSGAGEKWDNFQGKIDFIDCKFTYPSRPDIQVLNGLSVSVDPGQTLAFVGSSGCGKSTS 1122
Query: 3179 ISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGE 3358
I LLER YDP +G V +D +D +++N + LR +I +VSQEP+LFD SI +NI YG E
Sbjct: 1123 IQLLERFYDPDQGTVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFDCSIMDNIKYGDNTKE 1182
Query: 3359 YTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLL 3538
+ E+ A +A +H F+ LP+ YET VG +G+QLS G+KQRIAIARA++R+PKILLL
Sbjct: 1183 ISVERAIAAAKQAQLHDFVMSLPEKYETNVGIQGSQLSRGEKQRIAIARAIVRDPKILLL 1242
Query: 3539 DEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNE 3718
DEATSALDTESEK VQ+ALD A + RTCIV+AHRLSTI N+ I V+ G V+E+GTH +
Sbjct: 1243 DEATSALDTESEKTVQLALDKAREGRTCIVIAHRLSTIQNSDIIAVMSQGVVIEKGTHKK 1302
Query: 3719 LIAKRGAYFAL 3751
L+ ++GAY+ L
Sbjct: 1303 LMDQKGAYYKL 1313
Score = 375 bits (963), Expect = e-102
Identities = 221/576 (38%), Positives = 319/576 (55%), Gaps = 4/576 (0%)
Frame = +2
Query: 92 LAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHEVIQN 271
+ VG + + G P+ S++ + + F + +K R+E +
Sbjct: 755 ILVGALCAAINGAVTPIYSLLFSQILKTFSLV------------DKEQQRSE----IYSM 798
Query: 272 CLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYD--KNTSGTLS 445
CL +V LGC FLQ F E L+ R R+ F +++RQ+I W+D KN G L+
Sbjct: 799 CLFFVILGCVSLFTQFLQGYNFAKSGELLTKRLRKFGFKAMLRQDIGWFDDLKNNPGVLT 858
Query: 446 NKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFX 625
+L + +V+ TG +VG+ +AF ++W L+L++ PF+ + G
Sbjct: 859 TRLATDASQVQGATGSQVGMMVNSFTNIFVAVLIAFLFNWKLSLVISVFFPFLALSGAVQ 918
Query: 626 XXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKS 805
AG I E L++IRTV + K +E LE KT I+K+
Sbjct: 919 TKMLTGFASQDKEILEKAGQITNEALSNIRTVAGIGVEGRFIKAFEVELEKSYKTAIRKA 978
Query: 806 FLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQF 985
+ G A I + + A+ G + L V V S+ M + A+G+
Sbjct: 979 NVYGLCYAFSQGISFLANSAAYRYGGYLIVYEDLNFSYVFRVVSSIAMSATAVGRTFSYT 1038
Query: 986 ATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKG 1165
+ A +AA ++++DR P ID YS G+ G+I +FTYP+R D+++L G
Sbjct: 1039 PSYAKAKISAARFFQLLDRKPPIDVYSGAGEKWDNFQGKIDFIDCKFTYPSRPDIQVLNG 1098
Query: 1166 VSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGV 1345
+S+ PGQT+A VGSSGCGKST IQLL+RFY+PD G ++ID + N+++LR +G+
Sbjct: 1099 LSVSVDPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGTVMIDGHDSKKVNVQFLRSNIGI 1158
Query: 1346 VSQEPNLFNTSIEQNIRYG--RSDVSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQ 1519
VSQEP LF+ SI NI+YG ++S E A K+A DF+ + PE T VG +G Q
Sbjct: 1159 VSQEPVLFDCSIMDNIKYGDNTKEISVERAIAAAKQAQLHDFVMSLPEKYETNVGIQGSQ 1218
Query: 1520 MSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLS 1699
+S G+KQRIAIARA+VR+PKILLLDEATSALD ESE VQ AL+ A GRT IVIAHRLS
Sbjct: 1219 LSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQLALDKAREGRTCIVIAHRLS 1278
Query: 1700 TVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELV 1807
T++N+D I VM G V+E GTH+ L++QKG Y++LV
Sbjct: 1279 TIQNSDIIAVMSQGVVIEKGTHKKLMDQKGAYYKLV 1314
Score = 334 bits (857), Expect = 9e-90
Identities = 194/510 (38%), Positives = 286/510 (56%), Gaps = 1/510 (0%)
Frame = +2
Query: 2252 FQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDY 2431
FQ L+ + R ++R +R ++R + +FD S G + +R + D I AI
Sbjct: 158 FQIRLWVITGARQIRKMRKFYFRRIMRMEIGWFDCT--SVGELNSRFSDDINKIDEAIAD 215
Query: 2432 RLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEME 2611
++ +++ GL + FY GW++ +++A+ P + +G A++ + K
Sbjct: 216 QMALFLQRLSTALSGLLLGFYRGWKLTLVILAVSPLIGIGAAVIGLSVAKFTELELKAYA 275
Query: 2612 NAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFF 2791
AG A E + +IRTV A + K + +L I K ++ G G+ + FF
Sbjct: 276 KAGSIADEVLSSIRTVAAFGGENKEVERYEKNLMFAQRWGIWKGMVMGFFTGYMWCLIFF 335
Query: 2792 TYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIF 2971
YA AF +G L+ D+ P ++++ + + IG A+S + AA IF
Sbjct: 336 CYALAFWYGSRLVLDEGEYT-PGTLIQIFLCVIIAAMNIGNASSCLEIFSTGCSAASSIF 394
Query: 2972 NMLEEEPRIDGMTSSG-TYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALV 3148
++ +P +D M+ G ++ GE++ + V F YP RP V IL L++ +KPG+T A V
Sbjct: 395 QTIDRQPVMDCMSGDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNNLSMVIKPGETTAFV 454
Query: 3149 GPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRE 3328
G SG GKST + L++R YDP EG VT+D +D+R +N + LR I +V QEP+LF T+I E
Sbjct: 455 GSSGAGKSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAE 514
Query: 3329 NIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARA 3508
NI G + E T E I A AN + FI LP ++T VGE G Q+SGGQKQR+AIARA
Sbjct: 515 NIRLGRE--EATMEDIVQAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQKQRVAIARA 572
Query: 3509 LIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNG 3688
LIR PKILLLD ATSALD ESE +VQ AL+ T I VAHRLST+ +A I+ ++G
Sbjct: 573 LIRKPKILLLDMATSALDNESEAKVQGALNKIQHGHTIISVAHRLSTVRSADVIIGFEHG 632
Query: 3689 QVVEQGTHNELIAKRGAYFALTQKQSSNQS 3778
VE+GTH EL+ ++G YF L QS +
Sbjct: 633 TAVERGTHEELLERKGVYFMLVTLQSQEDN 662
>gi|17550138|ref|NP_509810.1| P-GlycoProtein related (pgp-5)
[Caenorhabditis elegans]
gi|7495402|pir||T18939 hypothetical protein C05A9.1 - Caenorhabditis
elegans
gi|3874030|emb|CAA94202.1| Hypothetical protein C05A9.1
[Caenorhabditis elegans]
Length = 1283
Score = 858 bits (2217), Expect = 0.0
Identities = 482/1239 (38%), Positives = 733/1239 (58%), Gaps = 1/1239 (0%)
Frame = +2
Query: 50 FQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEK 229
FQ+ + T+ ++L+ +G++ S TG+ P S +G SQ V + + +
Sbjct: 55 FQI-KCTTRYEKLLFFLGVVFSILTGMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDL 113
Query: 230 AAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEI 409
A A F ++ + L + +G F GFLQ S + + + RRQ+ ++R++I
Sbjct: 114 AHAYKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDI 173
Query: 410 AWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMS 589
+++D ++G LS L DN+ER RE +K+ L ++ F+ G +AF DW L
Sbjct: 174 SYFDGMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTV 233
Query: 590 LSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDA 769
S +++ GL + AG IA + L +TV + NGQ+ E +RY +
Sbjct: 234 FSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEE 293
Query: 770 LEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMM 949
L++G+K + ++F+ ++ + A + + G N +Y G +E G V+ + + ++
Sbjct: 294 LKNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGANMIYEGTIEPGVVVRILYYILF 353
Query: 950 GSMALGQAGQQFATIGTALGAAASLYEVI-DRIPEIDAYSTEGQTPSKISGRISVNKVEF 1126
GS LG+A + + +A+ + +++ D D + +E + G IS V F
Sbjct: 354 GSYCLGEAILHISRLASAIPLTVPIADILLDSDATADEFFSE-EIKDTFQGIISFKNVLF 412
Query: 1127 TYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIE 1306
+YPTR DV +LK +S + Q G+ +ALVG+SG GKST+IQLL +YN D+G+I ID I
Sbjct: 413 SYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIY 472
Query: 1307 DFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEG 1486
+ NIK LRQ +GVV QEP LFNTSIE+NIR+G+ D ++++I ALK ANA DF+ FP+G
Sbjct: 473 NINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDG 532
Query: 1487 LNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRG 1666
+ T+VG+RG Q+SGGQKQRIAIAR LVRNP+ILLLDEATSALD ESE IVQ AL+ AS G
Sbjct: 533 IKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIG 592
Query: 1667 RTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVDDKPK 1846
RTTIV+AHRLST+RNA+KIIVM+ G+++EVG H+ LI G+Y+ LV Q+ + + K
Sbjct: 593 RTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMST--NYEK 650
Query: 1847 KKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXGAVKA 2026
E E R++RQ+S N + ++D GA K+
Sbjct: 651 MNENEERVTRQSSHSDFPSN-EISHQKIDQEDDYVKKLIAEIKEE----------GAKKS 699
Query: 2027 NLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHFWA 2206
N+ +I++Y R E+ IQG P S + ++ D+D+M HFWA
Sbjct: 700 NICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYAF-DKDEMLSKSHFWA 758
Query: 2207 LMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITT 2386
L L LA + + FQ FG AE+L++++RS +++++ ++D P H+ R++
Sbjct: 759 LSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSN 818
Query: 2387 RLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMM 2566
RL D+ N+ +A+D RLGS+ + ++ + ++F+Y W+M+ V+ P + +
Sbjct: 819 RLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCND 878
Query: 2567 KYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAI 2746
+ + D+ E + + A+EA+EN+RTV+AL ++ ++ + SHL +A+
Sbjct: 879 NFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAV 938
Query: 2747 IRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASY 2926
I+G GFA S FF YA +F+FG +L+ + +L P + VL +S + G A +Y
Sbjct: 939 IQGTANGFACSCYFFIYAVSFKFGTWLVLREEIL--PMDTYLVLMTLSMTASYAGSAVAY 996
Query: 2927 FPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVFFRYPERPAVPILQG 3106
P++ KA AAGLIF++ + +S G +GE++L V F Y +R IL G
Sbjct: 997 LPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGKRNIKNGEIELKNVSFEYAQRSDKMILDG 1056
Query: 3107 LNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIAL 3286
+++ + G+TLALVGPSG GKST+ISLLER Y ++G V +D ++ +N HLR+ ++L
Sbjct: 1057 VSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSL 1116
Query: 3287 VSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQ 3466
VSQEP+LF+ SI+EN ++G+ + +I+ A AN F+ + P G +T VGE+G Q
Sbjct: 1117 VSQEPVLFNCSIKENFLFGISHNA-SQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQ 1175
Query: 3467 LSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLS 3646
LSGGQKQRIAIARA++RNPK+LLLDEATSALD++SEK VQ ALD A++ + +VVAHRLS
Sbjct: 1176 LSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLS 1235
Query: 3647 TIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQ 3763
T+VNA I V+KNG+V EQGTH EL+ KR Y+ L QKQ
Sbjct: 1236 TVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 1274
Score = 286 bits (732), Expect = 3e-75
Identities = 193/552 (34%), Positives = 285/552 (50%), Gaps = 8/552 (1%)
Frame = +2
Query: 2207 LMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITT 2386
L+F ++ T Q S+ + +R + +LR+D +YFD S G ++
Sbjct: 129 LLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFD--GMSTGHLSI 186
Query: 2387 RLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMM 2566
L + + + ++ I + G +AFY W++A +F F V L+
Sbjct: 187 VLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLA-CYGTVFSFGIVLSGLLD 245
Query: 2567 KYHGGSATSDAKEME---NAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNIS 2737
+ G ++ K+ E NAG A +A+ +TV +L Q + + L ++
Sbjct: 246 SW--GKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALN 303
Query: 2738 KAII----RGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGT 2905
+A + R Y F N++ F FG +I++ + EP V+R+L+ I F
Sbjct: 304 RAFVFSLSRSADYFFTNALNF----VILYFGANMIYEGTI--EPGVVVRILYYILFGSYC 357
Query: 2906 IGFAASYFPEYIKAT-FAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVFFRYPER 3082
+G A + A + +L+ + D S G + V F YP R
Sbjct: 358 LGEAILHISRLASAIPLTVPIADILLDSDATADEFFSEEIKDTFQGIISFKNVLFSYPTR 417
Query: 3083 PAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPK 3262
P VP+L+ ++ +V+ G+ +ALVG SG GKSTVI LL Y+ G +++D ND+ +N K
Sbjct: 418 PDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIK 477
Query: 3263 HLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYET 3442
LR+ + +V QEP+LF+TSI ENI +G + T ++I A AN F+ PDG +T
Sbjct: 478 QLRQAMGVVFQEPVLFNTSIEENIRFGKP--DATEQEIIDALKNANAFDFVCNFPDGIKT 535
Query: 3443 RVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTC 3622
VGE+G QLSGGQKQRIAIAR L+RNP+ILLLDEATSALD ESE VQ AL A+ RT
Sbjct: 536 IVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTT 595
Query: 3623 IVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSSNQSGGAFDTSE 3802
IVVAHRLSTI NA I+V++ G++VE G H +LIA G Y L Q Q + + + +E
Sbjct: 596 IVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNENE 655
Query: 3803 ALXXXXXXHVKF 3838
H F
Sbjct: 656 ERVTRQSSHSDF 667
>gi|13929072|ref|NP_113948.1| ATP-binding cassette, sub-family B
(MDR/TAP), member 11; sister of P-glycoprotein; bile salt
export pump [Rattus norvegicus]
gi|12585136|sp|O70127|AB11_RAT Bile salt export pump (ATP-binding
cassette, sub-family B, member 11) (Sister of
P-glycoprotein)
gi|11346285|pir||T42842 bile salt transport protein, ATP-dependent -
rat
gi|3075422|gb|AAC40084.1| bile salt export pump [Rattus norvegicus]
Length = 1321
Score = 858 bits (2217), Expect = 0.0
Identities = 492/1271 (38%), Positives = 726/1271 (56%), Gaps = 34/1271 (2%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVT------------ 184
+ F+L+R++S+ D ++ +G + + G+ P + II G ++ F+
Sbjct: 45 VGFFELFRFSSSKDIWLMLMGGVCALLHGMAQPGILIIFGIMTDIFIKYDIERQELEIPG 104
Query: 185 ---LGTIFLDPNSTASEK-----AAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFM 340
+ + NS+ + + E+I+ Y +G + G+ Q ++
Sbjct: 105 KACVNNTIVWINSSFHQNMTNGTVCGLVDIESEMIKFSGIYAGVGMTVLILGYFQIRLWV 164
Query: 341 VICEKLSNRFRRQFFHSVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMM 520
+ + R R+ +F +MR EI W+D + G L+++ D++E++ + D++ Q M
Sbjct: 165 ITGARQIRRMRKIYFRRIMRMEIGWFDCTSVGELNSRFADDIEKINDAIADQLAHFLQRM 224
Query: 521 AQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEV 700
+ + G + F W LTL+++++SP + I YA AG IA+EV
Sbjct: 225 STAMCGLLLGFYRGWKLTLVILAVSPLIGIGAAVIGLSIAKFTELELKAYAKAGSIADEV 284
Query: 701 LTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVG 880
L+SIRTV AF G+ E +RYE L ++ GI K ++G + +I+ Y LAFW G
Sbjct: 285 LSSIRTVAAFGGENKEVERYEKNLVFAQRWGIWKGMVMGFFTGYMWCLIFFCYALAFWYG 344
Query: 881 TNFVYSGR-LESGTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEID 1057
+ V GT++ +F V++ +M +G A T AA ++++ IDR P ID
Sbjct: 345 STLVLDEEEYTPGTLVQIFLCVILAAMNIGHASSCLEIFSTGCSAATNIFQTIDRQPVID 404
Query: 1058 AYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTI 1237
S +G +I G I + V F YP+R DVKIL +S+ +PG+T ALVGSSG GKST
Sbjct: 405 CMSGDGYKLDRIKGEIEFHNVTFHYPSRPDVKILDNLSMVIKPGETTALVGSSGAGKSTA 464
Query: 1238 IQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVS 1417
+QL+QRFY+P G + +D I NI++LR +G+V QEP LF+T+I +NIR+GR D +
Sbjct: 465 LQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAENIRFGREDAT 524
Query: 1418 DEDIARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDE 1597
EDI +A K+ANA +FI P+ +TLVG+ G QMSGGQKQR+AIARAL+RNPKILLLD
Sbjct: 525 MEDIVQAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDM 584
Query: 1598 ATSALDAESESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLI 1777
ATSALD ESE+ VQ AL G T I +AHRLSTVR AD II + G +E GTHE L+
Sbjct: 585 ATSALDNESEARVQEALNKIQHGHTIISVAHRLSTVRAADVIIGFEHGVAVERGTHEELL 644
Query: 1778 EQKGLYHELVHAQVFADVDDKPKK---KEA------ERRMSRQTSQRKGSVNFKTQ-ESQ 1927
E+KG+Y LV Q D K K+A ER SR + + + + + +SQ
Sbjct: 645 ERKGVYFMLVTLQSQGDNAHKETSIMGKDATEGGTLERTFSRGSYRDSLRASIRQRSKSQ 704
Query: 1928 VDXXXXX--XXXXXXXXXXXXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLI 2101
+ A + +IL+Y PEW Y I
Sbjct: 705 LSLLTHDPPLAVADHKSSYKDSKDNDVLVEEVEPAPVRRILKYNIPEWHYILVGSLSAAI 764
Query: 2102 QGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAA 2281
GAV P +SL FSQ++ FS D++Q + + H L F++L V + Q F +
Sbjct: 765 NGAVTPIYSLLFSQLLGTFSLLDKEQQRSEIHSMCLFFVILGCVSIFTQFLQGYTFAKSG 824
Query: 2282 ERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIA 2461
E LT R+R ++ +L QD +FD +++PG +TTRLATDA ++ A ++G + N+
Sbjct: 825 ELLTKRLRKFGFKAMLGQDIGWFDDLRNNPGVLTTRLATDASQVQGATGSQVGMMVNSFT 884
Query: 2462 SVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAI 2641
++ L IAF++ W+++ ++ FPF+A+ A+ K G A+ D + +E AG+ EA+
Sbjct: 885 NIIAALLIAFFFSWKLSLIITIFFPFLALSGAVQTKMLTGFASQDKQALEKAGQITSEAL 944
Query: 2642 ENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGL 2821
NIRTV + ++ + F L + + KA I GL + F+ I F +AA+R+G
Sbjct: 945 SNIRTVAGIGVEGRFIKAFEVELQTSYKTAVRKANIYGLCFAFSQGIAFLANSAAYRYGG 1004
Query: 2822 FLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRID 3001
+LI + + +V RV+ +++ S +G SY P Y KA +A F +L+ +P I+
Sbjct: 1005 YLIAYEGLGFS--HVFRVVSSVALSATAVGRTFSYTPSYAKAKISAARFFQLLDRKPPIN 1062
Query: 3002 GMTSSGT-YPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTV 3178
+ +G + G++ F YP RP + +L GL+V V PGQTLA VG SGCGKST
Sbjct: 1063 VYSEAGEKWDNFQGKIDFIDCKFTYPSRPDIQVLNGLSVSVNPGQTLAFVGSSGCGKSTS 1122
Query: 3179 ISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGE 3358
I LLER YDP +G V +D +D +++N + LR +I +VSQEP+LFD SI +NI YG E
Sbjct: 1123 IQLLERFYDPDQGTVMIDGHDSKKVNIQFLRSNIGIVSQEPVLFDCSIMDNIKYGDNTKE 1182
Query: 3359 YTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLL 3538
+ E+ A +A +H F+ LP+ YET VG +G+QLS G+KQRIAIARA++R+PKILLL
Sbjct: 1183 ISVERAIAAAKQAQLHDFVMSLPEKYETNVGIQGSQLSRGEKQRIAIARAIVRDPKILLL 1242
Query: 3539 DEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNE 3718
DEATSALDTESEK VQ ALD A + RTCIV+AHRLSTI N+ I VV G V+E+GTH +
Sbjct: 1243 DEATSALDTESEKTVQTALDKAREGRTCIVIAHRLSTIQNSDIIAVVSQGVVIEKGTHEK 1302
Query: 3719 LIAKRGAYFAL 3751
L+A++GAY+ L
Sbjct: 1303 LMAQKGAYYKL 1313
Score = 370 bits (949), Expect = e-100
Identities = 223/576 (38%), Positives = 320/576 (54%), Gaps = 4/576 (0%)
Frame = +2
Query: 92 LAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHEVIQN 271
+ VG + + G P+ S++ + LGT L +K R+E H +
Sbjct: 755 ILVGSLSAAINGAVTPIYSLLFSQL------LGTFSL------LDKEQQRSEI-HSM--- 798
Query: 272 CLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYD--KNTSGTLS 445
CL +V LGC FLQ F E L+ R R+ F +++ Q+I W+D +N G L+
Sbjct: 799 CLFFVILGCVSIFTQFLQGYTFAKSGELLTKRLRKFGFKAMLGQDIGWFDDLRNNPGVLT 858
Query: 446 NKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFX 625
+L + +V+ TG +VG+ I +AF + W L+LI+ PF+ + G
Sbjct: 859 TRLATDASQVQGATGSQVGMMVNSFTNIIAALLIAFFFSWKLSLIITIFFPFLALSGAVQ 918
Query: 626 XXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKS 805
AG I E L++IRTV + K +E L+ KT ++K+
Sbjct: 919 TKMLTGFASQDKQALEKAGQITSEALSNIRTVAGIGVEGRFIKAFEVELQTSYKTAVRKA 978
Query: 806 FLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQF 985
+ G A I + + A+ G + L V V SV + + A+G+
Sbjct: 979 NIYGLCFAFSQGIAFLANSAAYRYGGYLIAYEGLGFSHVFRVVSSVALSATAVGRTFSYT 1038
Query: 986 ATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKG 1165
+ A +AA ++++DR P I+ YS G+ G+I +FTYP+R D+++L G
Sbjct: 1039 PSYAKAKISAARFFQLLDRKPPINVYSEAGEKWDNFQGKIDFIDCKFTYPSRPDIQVLNG 1098
Query: 1166 VSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGV 1345
+S+ PGQT+A VGSSGCGKST IQLL+RFY+PD G ++ID + NI++LR +G+
Sbjct: 1099 LSVSVNPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGTVMIDGHDSKKVNIQFLRSNIGI 1158
Query: 1346 VSQEPNLFNTSIEQNIRYG--RSDVSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQ 1519
VSQEP LF+ SI NI+YG ++S E A K+A DF+ + PE T VG +G Q
Sbjct: 1159 VSQEPVLFDCSIMDNIKYGDNTKEISVERAIAAAKQAQLHDFVMSLPEKYETNVGIQGSQ 1218
Query: 1520 MSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLS 1699
+S G+KQRIAIARA+VR+PKILLLDEATSALD ESE VQ+AL+ A GRT IVIAHRLS
Sbjct: 1219 LSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQTALDKAREGRTCIVIAHRLS 1278
Query: 1700 TVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELV 1807
T++N+D I V+ G V+E GTHE L+ QKG Y++LV
Sbjct: 1279 TIQNSDIIAVVSQGVVIEKGTHEKLMAQKGAYYKLV 1314
Score = 341 bits (874), Expect = 9e-92
Identities = 199/510 (39%), Positives = 288/510 (56%), Gaps = 1/510 (0%)
Frame = +2
Query: 2252 FQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDY 2431
FQ L+ + R R+R +R ++R + +FD S G + +R A D I AI
Sbjct: 158 FQIRLWVITGARQIRRMRKIYFRRIMRMEIGWFDCT--SVGELNSRFADDIEKINDAIAD 215
Query: 2432 RLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEME 2611
+L +++ GL + FY GW++ +++A+ P + +G A++ + K
Sbjct: 216 QLAHFLQRMSTAMCGLLLGFYRGWKLTLVILAVSPLIGIGAAVIGLSIAKFTELELKAYA 275
Query: 2612 NAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFF 2791
AG A E + +IRTV A + K + +L I K ++ G G+ + FF
Sbjct: 276 KAGSIADEVLSSIRTVAAFGGENKEVERYEKNLVFAQRWGIWKGMVMGFFTGYMWCLIFF 335
Query: 2792 TYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIF 2971
YA AF +G L+ D+ P ++++ + + IG A+S + AA IF
Sbjct: 336 CYALAFWYGSTLVLDEEEYT-PGTLVQIFLCVILAAMNIGHASSCLEIFSTGCSAATNIF 394
Query: 2972 NMLEEEPRIDGMTSSG-TYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALV 3148
++ +P ID M+ G ++ GE++ + V F YP RP V IL L++ +KPG+T ALV
Sbjct: 395 QTIDRQPVIDCMSGDGYKLDRIKGEIEFHNVTFHYPSRPDVKILDNLSMVIKPGETTALV 454
Query: 3149 GPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRE 3328
G SG GKST + L++R YDP EG VT+D +D+R +N + LR I +V QEP+LF T+I E
Sbjct: 455 GSSGAGKSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAE 514
Query: 3329 NIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARA 3508
NI +G + + T E I A AN + FI LP ++T VGE G Q+SGGQKQR+AIARA
Sbjct: 515 NIRFGRE--DATMEDIVQAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQKQRVAIARA 572
Query: 3509 LIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNG 3688
LIRNPKILLLD ATSALD ESE +VQ AL+ T I VAHRLST+ A I+ ++G
Sbjct: 573 LIRNPKILLLDMATSALDNESEARVQEALNKIQHGHTIISVAHRLSTVRAADVIIGFEHG 632
Query: 3689 QVVEQGTHNELIAKRGAYFALTQKQSSNQS 3778
VE+GTH EL+ ++G YF L QS +
Sbjct: 633 VAVERGTHEELLERKGVYFMLVTLQSQGDN 662
>gi|12585141|sp|Q9N0V3|AB11_RABIT Bile salt export pump (ATP-binding
cassette, sub-family B, member 11) (Sister of
P-glycoprotein)
gi|7644354|gb|AAF65552.1| liver bile salt export pump [Oryctolagus
cuniculus]
Length = 1321
Score = 857 bits (2214), Expect = 0.0
Identities = 485/1272 (38%), Positives = 720/1272 (56%), Gaps = 35/1272 (2%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIF------- 199
I FQL+R++S D ++ +G + +C G+ P + +I G ++ F+ T
Sbjct: 45 IGFFQLFRFSSWTDIWLMCMGSLCACIHGIAQPGVLLIFGTMTDVFIDYDTELQELKIPG 104
Query: 200 --------------LDPNSTASEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCF 337
L+ N T + + E+I+ Y +G + G++Q +
Sbjct: 105 KACVNNTIVWINSSLNQNVTNGTRCGL-LDIESEMIRFAGYYAGIGIAVLTTGYIQICFW 163
Query: 338 MVICEKLSNRFRRQFFHSVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQM 517
+ + R+ +F +MR I W D N+ G L+ + ++ + + D++ + Q
Sbjct: 164 GIAAAHQIQKMRKSYFRKIMRMGIGWVDCNSVGKLNTPFSVDFNKINDSSADQLAIFIQG 223
Query: 518 MAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEE 697
M I GF V F+ W LTL+++S+SP + + YA AG +A+E
Sbjct: 224 MTSPIFGFLVGFSQWWKLTLVIISVSPLIGLGAAIIGLSVSKFTDYELKAYAKAGSVADE 283
Query: 698 VLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWV 877
V++S+RTV AF G++ E +RYE L ++ GI+K ++G + +I+ Y LAFW
Sbjct: 284 VISSMRTVAAFGGEKKEVERYEKNLVFAQRWGIRKGIVMGFFTGYMWCLIFFCYALAFWY 343
Query: 878 GTNFVYS-GRLESGTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEI 1054
G+ V G G ++ +F SV++G++ LG A AA+S++E IDR P I
Sbjct: 344 GSKLVLEEGEYSPGALVQIFLSVIIGALNLGNASPCLEAFAAGRAAASSIFETIDRKPII 403
Query: 1055 DAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKST 1234
D S +G +I G I + V F YP+R +VKIL +S+ +PG+ ALVG SG GKST
Sbjct: 404 DCMSEDGYKLERIKGEIEFHNVTFHYPSRPEVKILNNLSMVIKPGEMTALVGPSGAGKST 463
Query: 1235 IIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDV 1414
+QL+ RFY P G + ++ I +I++LR +G+V QEP LF +I + IRYGR D
Sbjct: 464 ALQLIHRFYGPTEGMVTVESHDIRSSHIQWLRNQIGIVEQEPVLFFHTIAEKIRYGREDA 523
Query: 1415 SDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLD 1594
+ ED+ +A KEANA +FI P+ +TLVG+ G QMSGGQKQR+AIARAL+RNPKILLLD
Sbjct: 524 TMEDLIQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLD 583
Query: 1595 EATSALDAESESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETL 1774
ATSALD ESE++VQ AL G T + +AHR +T+R AD II + G +E GT E L
Sbjct: 584 MATSALDNESEAMVQEALSKTQHGHTIVSVAHRPATIRTADVIIGCEHGAAVERGTEEEL 643
Query: 1775 IEQKGLYHELVHAQVFADVDDKPKKKE-------AERRMSRQTSQRKGSVNFKTQ-ESQV 1930
+E+KG+Y LV Q + D+ + ++ E+ SR Q + + + +SQ+
Sbjct: 644 LERKGVYFALVTLQSQRNQGDQEENEKDATEDDIPEKTFSRGNYQDSLRASLRQRSKSQL 703
Query: 1931 DXXXXXXXXXXXXXXXXXXXXXXXXXXGAVK----ANLFKILRYARPEWIYXXXXXXXXL 2098
A + A++ +I++ PEW Y
Sbjct: 704 SYLAHEPPMAVEDHKSTHEEDRKDKDLPAQEDIEPASVRRIMKLNAPEWPYMLLGSMGAA 763
Query: 2099 IQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVA 2278
+ GAV P ++ FSQI+ FS PD+++ + + L+F+ L V + Q F +
Sbjct: 764 VNGAVTPLYAFLFSQILGTFSLPDKEEQRSQINGICLLFVTLGCVSFFTQFLQGYTFAKS 823
Query: 2279 AERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAI 2458
E LT R+R +R +L QD +FD ++SPG +TTRLATDA ++ A ++G + N+
Sbjct: 824 GELLTKRLRKFGFRAMLGQDIGWFDDLRNSPGALTTRLATDASQVQGATGSQIGMMVNSF 883
Query: 2459 ASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEA 2638
+V + IAF + W++ ++ FPF+A+ AL K G A+ D + +E AG+ EA
Sbjct: 884 TNVTVAMIIAFLFSWKLTLGIVCFFPFLALSGALQTKMLTGFASRDKQALEKAGQITSEA 943
Query: 2639 IENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFG 2818
+ NIRTV + + K F + L+ P+ I KA + GL +GF+ I F +A++R+G
Sbjct: 944 LSNIRTVAGIGKERKFIETFEAELEKPYKMAIKKANVYGLCFGFSQCITFIANSASYRYG 1003
Query: 2819 LFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRI 2998
+LI ++ + V RV+ A+ S +G A+SY P Y KA +A F +L+ +P I
Sbjct: 1004 GYLISNEGLHFS--YVFRVISAVVLSATALGRASSYTPSYAKAKISAARFFQLLDRQPPI 1061
Query: 2999 DGMTSSGT-YPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKST 3175
+ +S+G + G++ F YP RP + +L GL+V + P QTLA VG SGCGKST
Sbjct: 1062 NVYSSAGEKWDNFQGKIDFVDCKFTYPSRPDIQVLNGLSVSMSPRQTLAFVGSSGCGKST 1121
Query: 3176 VISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPG 3355
I LLER YDP G V +D +D R++N + LR +I +VSQEP+LF SI++NI YG
Sbjct: 1122 SIQLLERFYDPDHGKVMIDGHDSRKVNIQFLRSNIGIVSQEPVLFACSIKDNIKYGDNTQ 1181
Query: 3356 EYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILL 3535
E E+I A KA +H F+ LP+ YET VG +G+QLS G+KQRIAIARA++R+PKILL
Sbjct: 1182 EIPMERIIAAAKKAQVHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILL 1241
Query: 3536 LDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHN 3715
LDEATSALDTESEK VQVALD A + RTCIV+AHRLSTI N+ I V+ G V+E+GTH
Sbjct: 1242 LDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNSDIIAVMSQGMVIEKGTHE 1301
Query: 3716 ELIAKRGAYFAL 3751
EL+ ++GAY+ L
Sbjct: 1302 ELMVQKGAYYKL 1313
Score = 369 bits (948), Expect = e-100
Identities = 209/516 (40%), Positives = 298/516 (57%), Gaps = 4/516 (0%)
Frame = +2
Query: 272 CLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYD--KNTSGTLS 445
CL +V LGC F FLQ F E L+ R R+ F +++ Q+I W+D +N+ G L+
Sbjct: 799 CLLFVTLGCVSFFTQFLQGYTFAKSGELLTKRLRKFGFRAMLGQDIGWFDDLRNSPGALT 858
Query: 446 NKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFX 625
+L + +V+ TG ++G+ +AF + W LTL ++ PF+ + G
Sbjct: 859 TRLATDASQVQGATGSQIGMMVNSFTNVTVAMIIAFLFSWKLTLGIVCFFPFLALSGALQ 918
Query: 626 XXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKS 805
AG I E L++IRTV + + +E LE K IKK+
Sbjct: 919 TKMLTGFASRDKQALEKAGQITSEALSNIRTVAGIGKERKFIETFEAELEKPYKMAIKKA 978
Query: 806 FLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQF 985
+ G I + + ++ G + + L V V +V++ + ALG+A
Sbjct: 979 NVYGLCFGFSQCITFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRASSYT 1038
Query: 986 ATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKG 1165
+ A +AA ++++DR P I+ YS+ G+ G+I +FTYP+R D+++L G
Sbjct: 1039 PSYAKAKISAARFFQLLDRQPPINVYSSAGEKWDNFQGKIDFVDCKFTYPSRPDIQVLNG 1098
Query: 1166 VSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGV 1345
+S+ P QT+A VGSSGCGKST IQLL+RFY+PD G+++ID NI++LR +G+
Sbjct: 1099 LSVSMSPRQTLAFVGSSGCGKSTSIQLLERFYDPDHGKVMIDGHDSRKVNIQFLRSNIGI 1158
Query: 1346 VSQEPNLFNTSIEQNIRYG--RSDVSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQ 1519
VSQEP LF SI+ NI+YG ++ E I A K+A DF+ + PE T VG +G Q
Sbjct: 1159 VSQEPVLFACSIKDNIKYGDNTQEIPMERIIAAAKKAQVHDFVMSLPEKYETNVGSQGSQ 1218
Query: 1520 MSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLS 1699
+S G+KQRIAIARA+VR+PKILLLDEATSALD ESE VQ AL+ A GRT IVIAHRLS
Sbjct: 1219 LSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLS 1278
Query: 1700 TVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELV 1807
T++N+D I VM G V+E GTHE L+ QKG Y++LV
Sbjct: 1279 TIQNSDIIAVMSQGMVIEKGTHEELMVQKGAYYKLV 1314
Score = 310 bits (795), Expect = 1e-82
Identities = 185/515 (35%), Positives = 278/515 (53%), Gaps = 1/515 (0%)
Frame = +2
Query: 2240 TSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKS 2419
T+ Q +G+AA ++R +R ++R + D +S G++ T + D I
Sbjct: 154 TTGYIQICFWGIAAAHQIQKMRKSYFRKIMRMGIGWVDC--NSVGKLNTPFSVDFNKIND 211
Query: 2420 AIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDA 2599
+ +L + S G + F W++ +++++ P + +G A++ +
Sbjct: 212 SSADQLAIFIQGMTSPIFGFLVGFSQWWKLTLVIISVSPLIGLGAAIIGLSVSKFTDYEL 271
Query: 2600 KEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANS 2779
K AG A E I ++RTV A + K + +L I K I+ G G+
Sbjct: 272 KAYAKAGSVADEVISSMRTVAAFGGEKKEVERYEKNLVFAQRWGIRKGIVMGFFTGYMWC 331
Query: 2780 IQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAA 2959
+ FF YA AF +G L+ ++ P ++++ ++ +G A+ + AA
Sbjct: 332 LIFFCYALAFWYGSKLVLEEGEY-SPGALVQIFLSVIIGALNLGNASPCLEAFAAGRAAA 390
Query: 2960 GLIFNMLEEEPRIDGMTSSG-TYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQT 3136
IF ++ +P ID M+ G ++ GE++ + V F YP RP V IL L++ +KPG+
Sbjct: 391 SSIFETIDRKPIIDCMSEDGYKLERIKGEIEFHNVTFHYPSRPEVKILNNLSMVIKPGEM 450
Query: 3137 LALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDT 3316
ALVGPSG GKST + L+ R Y P EG VTV+++D+R + + LR I +V QEP+LF
Sbjct: 451 TALVGPSGAGKSTALQLIHRFYGPTEGMVTVESHDIRSSHIQWLRNQIGIVEQEPVLFFH 510
Query: 3317 SIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIA 3496
+I E I YG + + T E + A +AN + FI +LP ++T VGE G Q+SGGQKQR+A
Sbjct: 511 TIAEKIRYGRE--DATMEDLIQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVA 568
Query: 3497 IARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMV 3676
IARALIRNPKILLLD ATSALD ESE VQ AL T + VAHR +TI A I+
Sbjct: 569 IARALIRNPKILLLDMATSALDNESEAMVQEALSKTQHGHTIVSVAHRPATIRTADVIIG 628
Query: 3677 VKNGQVVEQGTHNELIAKRGAYFALTQKQSSNQSG 3781
++G VE+GT EL+ ++G YFAL QS G
Sbjct: 629 CEHGAAVERGTEEELLERKGVYFALVTLQSQRNQG 663
>gi|7514034|pir||T42228 P-glycoprotein sister - rat
gi|3273484|gb|AAC24753.1| P-glycoprotein sister [Rattus norvegicus]
Length = 1321
Score = 857 bits (2214), Expect = 0.0
Identities = 492/1271 (38%), Positives = 725/1271 (56%), Gaps = 34/1271 (2%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVT------------ 184
+ F+L+R++S+ D ++ +G + + G+ P + II G ++ F+
Sbjct: 45 VGFFELFRFSSSKDIWLMLMGGVCALLHGMAQPGILIIFGIMTDIFIKYDIERQELEIPG 104
Query: 185 ---LGTIFLDPNSTASEK-----AAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFM 340
+ + NS+ + + E+I+ Y +G + G+ Q ++
Sbjct: 105 KACVNNTIVWINSSFHQNMTNGTVCGLVDIESEMIKFSGIYAGVGMTVLILGYFQIRLWV 164
Query: 341 VICEKLSNRFRRQFFHSVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMM 520
+ + R R+ +F +MR EI W+D + G L+++ D++E++ + D++ Q M
Sbjct: 165 ITGARQIRRMRKIYFRRIMRMEIGWFDCTSVGELNSRFADDIEKINDAIADQLAHFLQRM 224
Query: 521 AQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEV 700
+ + G + F W LTL+++++SP + I YA AG IA+EV
Sbjct: 225 STAMCGLLLGFYRGWKLTLVILAVSPLIGIGAAVIGLSIAKFTELELKAYAKAGSIADEV 284
Query: 701 LTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVG 880
L+SIRTV AF G+ E +RYE L ++ GI K ++G + +I+ Y LAFW G
Sbjct: 285 LSSIRTVAAFGGENKEVERYEKNLVFAQRWGIWKGMVMGFFTGYMWCLIFFCYALAFWYG 344
Query: 881 TNFVYSGR-LESGTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEID 1057
+ V GT++ +F V++ +M +G A T AA ++++ IDR P ID
Sbjct: 345 STLVLDEEEYTPGTLVQIFLCVILAAMNIGHASSCLEIFSTGCSAATNIFQTIDRQPVID 404
Query: 1058 AYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTI 1237
S +G +I G I + V F YP+R DVKIL +S+ +PG+T ALVGSSG GKST
Sbjct: 405 CMSGDGYKLDRIKGEIEFHNVTFHYPSRPDVKILDNLSMVIKPGETTALVGSSGAGKSTA 464
Query: 1238 IQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVS 1417
+QL+QRFY+P G + +D I NI++LR +G+V QEP LF+T+I +NIR+GR D +
Sbjct: 465 LQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAENIRFGREDAT 524
Query: 1418 DEDIARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDE 1597
EDI +A K+ANA +FI P+ +TLVG+ G QMSGGQKQR+AIARAL+RNPKILLLD
Sbjct: 525 MEDIVQAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDM 584
Query: 1598 ATSALDAESESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLI 1777
ATSALD ESE+ VQ AL G T I +AHRLSTVR AD II + G +E GTHE L+
Sbjct: 585 ATSALDNESEARVQEALNKIQHGHTIISVAHRLSTVRAADVIIGFEHGVAVERGTHEELL 644
Query: 1778 EQKGLYHELVHAQVFADVDDKPKK---KEA------ERRMSRQTSQRKGSVNFKTQ-ESQ 1927
E+KG+Y LV Q D K K+A ER SR + + + + + +SQ
Sbjct: 645 ERKGVYFMLVTLQSQGDNAHKETSIMGKDATEGGTLERTFSRGSYRDSLRASIRQRSKSQ 704
Query: 1928 VDXXXXX--XXXXXXXXXXXXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLI 2101
+ A + +IL+Y PEW Y I
Sbjct: 705 LSLLTHDPPLAVADHKSSYKDSKDNDVLVEEVEPAPVRRILKYNIPEWHYILVGSLSAAI 764
Query: 2102 QGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAA 2281
GAV P +SL FSQ++ FS D++Q + + H L F++L V + Q F +
Sbjct: 765 NGAVTPIYSLLFSQLLGTFSLLDKEQQRSEIHSMCLFFVILGCVSIFTQFLQGYTFAKSG 824
Query: 2282 ERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIA 2461
E LT R+R ++ +L QD +FD +++PG +TTRLATDA ++ A ++G + N+
Sbjct: 825 ELLTKRLRKFGFKAMLGQDIGWFDDLRNNPGVLTTRLATDASQVQGATGSQVGMMVNSFT 884
Query: 2462 SVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAI 2641
++ L IAF++ W+++ ++ FPF+A+ A+ K G A+ D + +E AG+ EA+
Sbjct: 885 NIIAALLIAFFFSWKLSLIITIFFPFLALSGAVQTKMLTGFASQDKQALEKAGQITSEAL 944
Query: 2642 ENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGL 2821
NIRTV + ++ + F L + + KA I GL + F+ I F +AA+R+G
Sbjct: 945 SNIRTVAGIGVEGRFIKAFEVELQTSYKTAVRKANIYGLCFAFSQGIAFLANSAAYRYGG 1004
Query: 2822 FLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRID 3001
+LI + + +V RV+ ++ S +G SY P Y KA +A F +L+ +P I+
Sbjct: 1005 YLIAYEGLGFS--HVFRVVSSVVLSATAVGRTFSYTPSYAKAKISAARFFQLLDRKPPIN 1062
Query: 3002 GMTSSGT-YPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTV 3178
+ +G + G++ F YP RP + +L GL+V V PGQTLA VG SGCGKST
Sbjct: 1063 VYSEAGEKWDNFQGKIDFIDCKFTYPSRPDIQVLNGLSVSVNPGQTLAFVGSSGCGKSTS 1122
Query: 3179 ISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGE 3358
I LLER YDP +G V +D +D +++N + LR +I +VSQEP+LFD SI +NI YG E
Sbjct: 1123 IQLLERFYDPDQGTVMIDGHDSKKVNIQFLRSNIGIVSQEPVLFDCSIMDNIKYGDNTKE 1182
Query: 3359 YTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLL 3538
+ E+ A +A +H F+ LP+ YET VG +G+QLS G+KQRIAIARA++R+PKILLL
Sbjct: 1183 ISVERAIAAAKQAQLHDFVMSLPEKYETNVGIQGSQLSRGEKQRIAIARAIVRDPKILLL 1242
Query: 3539 DEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNE 3718
DEATSALDTESEK VQ ALD A + RTCIV+AHRLSTI N+ I VV G V+E+GTH +
Sbjct: 1243 DEATSALDTESEKTVQTALDKAREGRTCIVIAHRLSTIQNSDIIAVVSQGVVIEKGTHEK 1302
Query: 3719 LIAKRGAYFAL 3751
L+A++GAY+ L
Sbjct: 1303 LMAQKGAYYKL 1313
Score = 370 bits (951), Expect = e-100
Identities = 223/576 (38%), Positives = 321/576 (55%), Gaps = 4/576 (0%)
Frame = +2
Query: 92 LAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHEVIQN 271
+ VG + + G P+ S++ + LGT L +K R+E H +
Sbjct: 755 ILVGSLSAAINGAVTPIYSLLFSQL------LGTFSL------LDKEQQRSEI-HSM--- 798
Query: 272 CLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYD--KNTSGTLS 445
CL +V LGC FLQ F E L+ R R+ F +++ Q+I W+D +N G L+
Sbjct: 799 CLFFVILGCVSIFTQFLQGYTFAKSGELLTKRLRKFGFKAMLGQDIGWFDDLRNNPGVLT 858
Query: 446 NKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFX 625
+L + +V+ TG +VG+ I +AF + W L+LI+ PF+ + G
Sbjct: 859 TRLATDASQVQGATGSQVGMMVNSFTNIIAALLIAFFFSWKLSLIITIFFPFLALSGAVQ 918
Query: 626 XXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKS 805
AG I E L++IRTV + K +E L+ KT ++K+
Sbjct: 919 TKMLTGFASQDKQALEKAGQITSEALSNIRTVAGIGVEGRFIKAFEVELQTSYKTAVRKA 978
Query: 806 FLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQF 985
+ G A I + + A+ G + L V V SV++ + A+G+
Sbjct: 979 NIYGLCFAFSQGIAFLANSAAYRYGGYLIAYEGLGFSHVFRVVSSVVLSATAVGRTFSYT 1038
Query: 986 ATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKG 1165
+ A +AA ++++DR P I+ YS G+ G+I +FTYP+R D+++L G
Sbjct: 1039 PSYAKAKISAARFFQLLDRKPPINVYSEAGEKWDNFQGKIDFIDCKFTYPSRPDIQVLNG 1098
Query: 1166 VSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGV 1345
+S+ PGQT+A VGSSGCGKST IQLL+RFY+PD G ++ID + NI++LR +G+
Sbjct: 1099 LSVSVNPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGTVMIDGHDSKKVNIQFLRSNIGI 1158
Query: 1346 VSQEPNLFNTSIEQNIRYG--RSDVSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQ 1519
VSQEP LF+ SI NI+YG ++S E A K+A DF+ + PE T VG +G Q
Sbjct: 1159 VSQEPVLFDCSIMDNIKYGDNTKEISVERAIAAAKQAQLHDFVMSLPEKYETNVGIQGSQ 1218
Query: 1520 MSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLS 1699
+S G+KQRIAIARA+VR+PKILLLDEATSALD ESE VQ+AL+ A GRT IVIAHRLS
Sbjct: 1219 LSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQTALDKAREGRTCIVIAHRLS 1278
Query: 1700 TVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELV 1807
T++N+D I V+ G V+E GTHE L+ QKG Y++LV
Sbjct: 1279 TIQNSDIIAVVSQGVVIEKGTHEKLMAQKGAYYKLV 1314
Score = 341 bits (874), Expect = 9e-92
Identities = 199/510 (39%), Positives = 288/510 (56%), Gaps = 1/510 (0%)
Frame = +2
Query: 2252 FQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDY 2431
FQ L+ + R R+R +R ++R + +FD S G + +R A D I AI
Sbjct: 158 FQIRLWVITGARQIRRMRKIYFRRIMRMEIGWFDCT--SVGELNSRFADDIEKINDAIAD 215
Query: 2432 RLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEME 2611
+L +++ GL + FY GW++ +++A+ P + +G A++ + K
Sbjct: 216 QLAHFLQRMSTAMCGLLLGFYRGWKLTLVILAVSPLIGIGAAVIGLSIAKFTELELKAYA 275
Query: 2612 NAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFF 2791
AG A E + +IRTV A + K + +L I K ++ G G+ + FF
Sbjct: 276 KAGSIADEVLSSIRTVAAFGGENKEVERYEKNLVFAQRWGIWKGMVMGFFTGYMWCLIFF 335
Query: 2792 TYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIF 2971
YA AF +G L+ D+ P ++++ + + IG A+S + AA IF
Sbjct: 336 CYALAFWYGSTLVLDEEEYT-PGTLVQIFLCVILAAMNIGHASSCLEIFSTGCSAATNIF 394
Query: 2972 NMLEEEPRIDGMTSSG-TYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALV 3148
++ +P ID M+ G ++ GE++ + V F YP RP V IL L++ +KPG+T ALV
Sbjct: 395 QTIDRQPVIDCMSGDGYKLDRIKGEIEFHNVTFHYPSRPDVKILDNLSMVIKPGETTALV 454
Query: 3149 GPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRE 3328
G SG GKST + L++R YDP EG VT+D +D+R +N + LR I +V QEP+LF T+I E
Sbjct: 455 GSSGAGKSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAE 514
Query: 3329 NIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARA 3508
NI +G + + T E I A AN + FI LP ++T VGE G Q+SGGQKQR+AIARA
Sbjct: 515 NIRFGRE--DATMEDIVQAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQKQRVAIARA 572
Query: 3509 LIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNG 3688
LIRNPKILLLD ATSALD ESE +VQ AL+ T I VAHRLST+ A I+ ++G
Sbjct: 573 LIRNPKILLLDMATSALDNESEARVQEALNKIQHGHTIISVAHRLSTVRAADVIIGFEHG 632
Query: 3689 QVVEQGTHNELIAKRGAYFALTQKQSSNQS 3778
VE+GTH EL+ ++G YF L QS +
Sbjct: 633 VAVERGTHEELLERKGVYFMLVTLQSQGDN 662
>gi|48094917|ref|XP_394305.1| similar to ENSANGP00000021663 [Apis
mellifera]
Length = 5485
Score = 854 bits (2207), Expect = 0.0
Identities = 490/1308 (37%), Positives = 719/1308 (54%), Gaps = 71/1308 (5%)
Frame = +2
Query: 59 YRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVS--------QNFVTLGTIF----- 199
+R+ + + +++ G+I+ TG+ +P+ +I G + +N + T+
Sbjct: 3730 FRFATCGELMLIFGGLIMGTLTGLCIPISTIQYGEFTTLLVDRNMKNHTSTPTLIMKWFG 3789
Query: 200 ----LDPNSTASEKAAARAEFS--HEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLS 361
L NST E+ A + S V L +F L + I
Sbjct: 3790 GGKVLGSNSTYKERMEALYDDSVAFGVSSAALSTFQFVFAVFTVDLLNVAASRQIV---- 3845
Query: 362 NRFRRQFFHSVMRQEIAWYDKNTSGTLSNKLFD--------------------------- 460
R R+ F SV+RQ++ WYD NTS ++++ D
Sbjct: 3846 -RVRKMFLRSVLRQDMTWYDINTSTNFASRITDGNNLVNNLRDDAVFCHNGDRRGNHGGF 3904
Query: 461 ----------------NLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSL 592
+L+++++G G+K+G+ +M FI ++F Y W LTL+++S
Sbjct: 3905 DLEDECKRDRVDGGAKDLDKMKDGIGEKLGVFTYLMVSFISSIIISFVYGWKLTLVVLSC 3964
Query: 593 SPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDAL 772
+P ++I Y AG +AEEVL +IRTVIAFNG++ E RY + L
Sbjct: 3965 APIIVIATAVVAKVQSSLTAQELTAYGQAGSVAEEVLGAIRTVIAFNGEQKEVNRYAEKL 4024
Query: 773 EHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLES------GTVLTVF 934
+KTGIK+ G G + IIY SY +AFW G + R + ++ VF
Sbjct: 4025 IPAEKTGIKRGMWSGVGGGVMWFIIYISYAIAFWYGVQLILEDRPKEVKEYTPAVLVIVF 4084
Query: 935 FSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVN 1114
F V+ G+ +G A G+AA++++V+DR+P ID+ S EGQ ++G I
Sbjct: 4085 FGVLAGAQNMGLTSPHLEAFAVARGSAAAIFQVLDRVPTIDSLSKEGQKLPAVNGEIEFK 4144
Query: 1115 KVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDD 1294
V F YP R DVK+L+G++L G+TVALVG SGCGKST +QL+QR Y+P GQ+L+D
Sbjct: 4145 NVHFQYPARKDVKVLQGLNLTINRGETVALVGGSGCGKSTCLQLIQRLYDPHKGQVLLDG 4204
Query: 1295 IPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKT 1474
+ + N+++LR +GVV QEP LF+T+I +NIRYG +++E++ +A KEANA DFI
Sbjct: 4205 VDVSKLNVQWLRSHIGVVGQEPVLFDTTIRENIRYGNDSITEEEMIKAAKEANAHDFISK 4264
Query: 1475 FPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALEN 1654
PE ++ VG+RG QMSGGQKQRIAIARALVR P ILLLDEATSALD SE+ VQ AL+
Sbjct: 4265 LPEAYDSPVGERGSQMSGGQKQRIAIARALVRRPAILLLDEATSALDLHSEATVQRALDA 4324
Query: 1655 ASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVD 1834
AS+GRTTIV+ HRLST+ NAD+I+ +K GQV+E GTHE L+ Y+ LV A A
Sbjct: 4325 ASKGRTTIVVTHRLSTITNADRIVFIKDGQVVEQGTHEELLALGKHYYGLVSADASATAR 4384
Query: 1835 DKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXG 2014
K A+ + Q+ + Q
Sbjct: 4385 AKATASAAKTVTAAIPKQK------PPLKRQFSTLSMHSHRLSLAGASETSANQLEEHEK 4438
Query: 2015 AVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDG 2194
A + +I +PEW Y + GA PAF++ F ++ V D ++++++
Sbjct: 4439 PYDAPMMRIFGLNKPEWPYNIIGCLAAAMVGASFPAFAVLFGEVYYVLGLQDDEEVRRET 4498
Query: 2195 HFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPG 2374
++++FLV+ V G Q +FG+A R+T RIR + +L+Q+ ++D +S G
Sbjct: 4499 VNFSILFLVVGVVTGLGTFLQMYMFGLAGVRMTTRIRKITFAAMLKQEMGWYDEDTNSVG 4558
Query: 2375 RITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQ 2554
+ RL++DA ++ A R+G+I A++++ G+G++ YY W+M + + P +
Sbjct: 4559 ALCARLSSDAGAVQGATGTRVGAILQALSTLVLGIGLSMYYTWKMTLVSVVSIPLVLGAV 4618
Query: 2555 ALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNI 2734
+ G + K+ME A + A+EAI NIRTV +L + +CS LD
Sbjct: 4619 FFEARVMSGQGLQEKKKMEAATRIAIEAISNIRTVASLGKEEAFLQRYCSELDHVAEATR 4678
Query: 2735 SKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGF 2914
+ +RGL + + FF YA + +G L+ + + ++V++V A+ F +G
Sbjct: 4679 IRQRLRGLVFSCGQTTPFFGYALSLYYGGALVATEG--LNYQDVIKVSEALIFGSWMLGQ 4736
Query: 2915 AASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYP---QLSGEVKLNKVFFRYPERP 3085
A ++ P + A +AG IF +L+ P I S + G ++ +KV F YP RP
Sbjct: 4737 ALAFAPNFNTAKISAGRIFKLLDRVPEIASPPDSEDKDLDWKADGLIQFSKVEFHYPTRP 4796
Query: 3086 AVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKH 3265
+ ILQGLN+ VKPGQ +ALVG SGCGKST I LL+RLYDP+ G VT+D D+ ++ ++
Sbjct: 4797 EMQILQGLNLIVKPGQMVALVGQSGCGKSTCIQLLQRLYDPISGTVTMDRRDISSVSLRN 4856
Query: 3266 LRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETR 3445
LR + +V QEP+LFD +I ENI YG ++I A K+NIH F+ LP GY+TR
Sbjct: 4857 LRSQLGVVGQEPVLFDRTIAENIAYGDNFRLVPMDEIIEAAKKSNIHSFVSSLPLGYDTR 4916
Query: 3446 VGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCI 3625
+G KGTQLSGGQKQRIAIARAL+RNP++LLLDEATSALDT+SEK VQ ALD A + RTCI
Sbjct: 4917 LGSKGTQLSGGQKQRIAIARALVRNPRVLLLDEATSALDTQSEKVVQAALDKAMEGRTCI 4976
Query: 3626 VVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSS 3769
+AHRL+TI NA I V++ G V E GTH++LIA G Y L Q +
Sbjct: 4977 TIAHRLATIRNADVICVLEKGTVAEMGTHDDLIAADGLYAHLHALQEA 5024
Score = 71.2 bits (173), Expect = 2e-10
Identities = 61/249 (24%), Positives = 117/249 (46%), Gaps = 3/249 (1%)
Frame = +2
Query: 1070 EGQTPSKISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLL 1249
E QT + G V KV T + ++ + +L G+ +L+G +G GK+TII++L
Sbjct: 2575 EKQTGVRFDG---VRKVYNT--DQGEIVAVDDFTLKLSEGEVTSLLGRNGAGKTTIIKML 2629
Query: 1250 QRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSI--EQNIRYGRSDVSDE 1423
P G+I ++ + + +GV Q+ L T E + Y + S E
Sbjct: 2630 TGMLAPTTGEICLN-------GEEGCKPDIGVCPQDNVLIGTLTPREHLLFYAKLKRSKE 2682
Query: 1424 DIARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEAT 1603
+ A + N + + + L + + ++SGG K+R+ +A A + +PK+++LDE
Sbjct: 2683 EYANV--QRNVDEMLTSLE--LGSQEHEPVYRLSGGTKRRLCVALAFLGSPKLVILDEPG 2738
Query: 1604 SALDAESESIVQSALENASRGRTTIVIAHRLSTVRN-ADKIIVMKAGQVMEVGTHETLIE 1780
+ +D + + ++ GRT I+ H L +D ++VM G+++ G+ +L
Sbjct: 2739 AGVDPAARRRIWRLIDQHRTGRTVILSTHHLDEADTLSDTVVVMHKGKILCTGSPLSLKM 2798
Query: 1781 QKGLYHELV 1807
G + L+
Sbjct: 2799 MHGRGYRLL 2807
Score = 70.1 bits (170), Expect = 4e-10
Identities = 62/291 (21%), Positives = 128/291 (43%), Gaps = 4/291 (1%)
Frame = +2
Query: 2891 FSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVFFR 3070
F + IG+ + + + + A L N + R DG+ Y GE+
Sbjct: 2547 FLYAVIGYLIARYTNSDEESNATSLTVNEKQTGVRFDGVRK--VYNTDQGEIVA------ 2598
Query: 3071 YPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQ 3250
+ + + G+ +L+G +G GK+T+I +L + P G + ++ +
Sbjct: 2599 ---------VDDFTLKLSEGEVTSLLGRNGAGKTTIIKMLTGMLAPTTGEICLNGEE--- 2646
Query: 3251 MNPKHLRKHIALVSQEPILFDT-SIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELP 3427
+ I + Q+ +L T + RE++++ + E AN+ + +DE+
Sbjct: 2647 ----GCKPDIGVCPQDNVLIGTLTPREHLLFYAKLKRSKEEY-------ANVQRNVDEML 2695
Query: 3428 DGYE--TRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDA 3601
E ++ E +LSGG K+R+ +A A + +PK+++LDE + +D + +++ +D
Sbjct: 2696 TSLELGSQEHEPVYRLSGGTKRRLCVALAFLGSPKLVILDEPGAGVDPAARRRIWRLIDQ 2755
Query: 3602 AAKDRTCIVVAHRLSTI-VNAGCIMVVKNGQVVEQGTHNELIAKRGAYFAL 3751
RT I+ H L + ++V+ G+++ G+ L G + L
Sbjct: 2756 HRTGRTVILSTHHLDEADTLSDTVVVMHKGKILCTGSPLSLKMMHGRGYRL 2806
Score = 54.3 bits (129), Expect = 2e-05
Identities = 46/219 (21%), Positives = 107/219 (48%), Gaps = 8/219 (3%)
Frame = +2
Query: 1157 LKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQIL-----IDDIPIEDFNIK 1321
++ +S+ + G+ L+G++G GKST ++L P AG+I+ I P+ + +
Sbjct: 3446 VQNLSIGVEAGKCFGLLGTNGAGKSTTFRMLTTEIIPTAGRIIVRGKEIGSGPLCNGEVG 3505
Query: 1322 YLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEA-NAADFIKTFPEGLNTL 1498
Y Q G+ S Q + ++ +A++ A D +K + +++L
Sbjct: 3506 YCPQSDGIDG------FLSPHQCLTIHGEVCGLSNVPKAVESALKRLDLLKYAHKRVSSL 3559
Query: 1499 VGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTI 1678
SGG K+++ A +++ ++L+DE TS +D ++ +V +++ +R +T +
Sbjct: 3560 --------SGGNKRKLCTALSVMAPVPVVLMDEPTSGMDPATKDLVTKTIKHLTRNQTCV 3611
Query: 1679 VI-AHRLSTVRN-ADKIIVMKAGQVMEVGTHETLIEQKG 1789
++ +H ++ N +++ ++ + +GT + L + G
Sbjct: 3612 ILTSHSVADCENVCNRVGILAKAGLRCIGTPQHLKHKFG 3650
Score = 47.0 bits (110), Expect = 0.004
Identities = 38/180 (21%), Positives = 80/180 (44%), Gaps = 2/180 (1%)
Frame = +2
Query: 3098 LQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKH 3277
+Q L++ V+ G+ L+G +G GKST +L P G + V ++ +
Sbjct: 3446 VQNLSIGVEAGKCFGLLGTNGAGKSTTFRMLTTEIIPTAGRIIVRGKEIG--SGPLCNGE 3503
Query: 3278 IALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETR--VG 3451
+ Q + I L P + E C +N+ K ++ +
Sbjct: 3504 VGYCPQS---------DGIDGFLSPHQCLTIHGEV-CGLSNVPKAVESALKRLDLLKYAH 3553
Query: 3452 EKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVV 3631
++ + LSGG K+++ A +++ ++L+DE TS +D ++ V + +++TC+++
Sbjct: 3554 KRVSSLSGGNKRKLCTALSVMAPVPVVLMDEPTSGMDPATKDLVTKTIKHLTRNQTCVIL 3613
>gi|15228695|ref|NP_191774.1| multidrug resistant (MDR) ABC
transporter, putative [Arabidopsis thaliana]
gi|11277353|pir||T48007 P-glycoprotein homolog T17J13.110
[similarity] - Arabidopsis thaliana
gi|6899925|emb|CAB71875.1| P-glycoprotein-like proetin [Arabidopsis
thaliana]
Length = 1292
Score = 851 bits (2198), Expect = 0.0
Identities = 474/1246 (38%), Positives = 725/1246 (58%), Gaps = 7/1246 (0%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+ +L+ + + D +++ +G I + G+G P+M+I+ G+V F N +
Sbjct: 63 VPFHKLFAFADSFDIILMILGTIGAVGNGLGFPIMTILFGDVIDVF--------GQNQNS 114
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
S+ S ++ + LK+VYLG G A LQ S +M+ E+ + R R + +++R
Sbjct: 115 SD-------VSDKIAKVALKFVYLGLGTLVAALLQVSGWMISGERQAGRIRSLYLQTILR 167
Query: 401 QEIAWYDKNTS-GTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
Q+IA++D T+ G + ++ + +++ G+KVG A Q+++ FIGGF +AFT WLLTL
Sbjct: 168 QDIAFFDVETNTGEVVGRMSGDTVLIQDAMGEKVGKAIQLVSTFIGGFVIAFTEGWLLTL 227
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
+M+S P +++ G YA A + E+ + SIRTV +F G++
Sbjct: 228 VMVSSIPLLVMSGAALAIVISKMASRGQTSYAKAAVVVEQTVGSIRTVASFTGEKQAISN 287
Query: 758 YEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFF 937
Y L + G+ + G GL + ++I+ +Y LA W G + G VL + F
Sbjct: 288 YNKHLVSAYRAGVFEGASTGLGLGTLNIVIFCTYALAVWYGGKMILEKGYTGGQVLIIIF 347
Query: 938 SVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNK 1117
+V+ GSM+LGQA + AA ++E I R PEIDA T G+ I G I +N
Sbjct: 348 AVLTGSMSLGQASPCLSAFAAGQAAAYKMFEAIKRKPEIDASDTTGKVLDDIRGDIELNN 407
Query: 1118 VEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDI 1297
V F+YP R + +I +G SL G TVALVG SG GKST++ L++RFY+P +G++ ID I
Sbjct: 408 VNFSYPARPEEQIFRGFSLSISSGSTVALVGQSGSGKSTVVSLIERFYDPQSGEVRIDGI 467
Query: 1298 PIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTF 1477
+++F +K++R +G+VSQEP LF +SI++NI YG+ + + E+I +A + ANA+ FI
Sbjct: 468 NLKEFQLKWIRSKIGLVSQEPVLFTSSIKENIAYGKENATVEEIRKATELANASKFIDKL 527
Query: 1478 PEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENA 1657
P+GL+T+VG+ G Q+SGGQKQRIA+ARA++++P+ILLLDEATSALDAESE IVQ AL+
Sbjct: 528 PQGLDTMVGEHGTQLSGGQKQRIAVARAILKDPRILLLDEATSALDAESERIVQEALDRI 587
Query: 1658 SRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLI-EQKGLYHELVHAQVFA-DV 1831
RTT+V+AHRLSTVRNAD I V+ G+++E G+H L+ + +G Y +L+ Q
Sbjct: 588 MVNRTTVVVAHRLSTVRNADMIAVIHQGKIVEKGSHSELLRDPEGAYSQLIRLQEDTKQT 647
Query: 1832 DDKPKKKEAERRMSRQTSQRKGSVN--FKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXX 2005
+D +++ +++S RK S++ + S
Sbjct: 648 EDSTDEQKLSMESMKRSSLRKSSLSRSLSKRSSSFSMFGFPAGIDTNNEAIPEKDIKVST 707
Query: 2006 XXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMK 2185
K + F++ +PE ++ G ++P F + S +I F P +Q+K
Sbjct: 708 PIKEKKVSFFRVAALNKPEIPMLILGSIAAVLNGVILPIFGILISSVIKAFFKPP-EQLK 766
Query: 2186 KDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKH 2365
D FWA++F++L Q F +A +L RIRS + V+R + +FD ++
Sbjct: 767 SDTRFWAIIFMLLGVASMVVFPAQTIFFSIAGCKLVQRIRSMCFEKVVRMEVGWFDETEN 826
Query: 2366 SPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMA 2545
S G I RL+ DA ++ + L +ASV GL IAF WQ+AF+V+A+ P +
Sbjct: 827 SSGAIGARLSADAATVRGLVGDALAQTVQNLASVTAGLVIAFVASWQLAFIVLAMLPLIG 886
Query: 2546 VGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHG 2725
+ + MK+ G + +DAKE A + A +A+ +IRTV + + K+ ++ + P
Sbjct: 887 LNGYIYMKFMVGFS-ADAKE---ASQVANDAVGSIRTVASFCAEEKVMKMYKKKCEGPMR 942
Query: 2726 GNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGT 2905
I + I+ G+ +G + + F +YAA+F G L+ D + +V RV FA++ +
Sbjct: 943 TGIRQGIVSGIGFGVSFFVLFSSYAASFYAGARLVDDGKTTFD--SVFRVFFALTMAAVA 1000
Query: 2906 IGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSG-TYPQLSGEVKLNKVFFRYPER 3082
I ++S P+ KA+ AA IF +++ E +ID SG + G+++L + F+YP R
Sbjct: 1001 ISQSSSLSPDSSKASNAAASIFAVIDRESKIDPSDESGRVLDNVKGDIELRHISFKYPSR 1060
Query: 3083 PAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPK 3262
P V I Q L + ++ G+T+ALVG SG GKSTVI+LL+R YDP G +T+D +++ + K
Sbjct: 1061 PDVQIFQDLCLSIRAGKTIALVGESGSGKSTVIALLQRFYDPDSGQITLDGVEIKTLQLK 1120
Query: 3263 HLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYET 3442
LR+ LVSQEP+LF+ +IR NI YG + G+ T +I +A +N H FI L GY+T
Sbjct: 1121 WLRQQTGLVSQEPVLFNETIRANIAYG-KGGDATETEIVSAAELSNAHGFISGLQQGYDT 1179
Query: 3443 RVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTC 3622
VGE+G QLSGGQKQR+AIARA++++PK+LLLDEATSALD ESE+ VQ ALD +RT
Sbjct: 1180 MVGERGVQLSGGQKQRVAIARAIVKDPKVLLLDEATSALDAESERVVQDALDRVMVNRTT 1239
Query: 3623 IVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELI-AKRGAYFALTQ 3757
+VVAHRLSTI NA I VVKNG +VE+G H LI K G Y +L Q
Sbjct: 1240 VVVAHRLSTIKNADVIAVVKNGVIVEKGKHETLINIKDGVYASLVQ 1285
Score = 382 bits (981), Expect = e-104
Identities = 222/583 (38%), Positives = 326/583 (55%), Gaps = 4/583 (0%)
Frame = +2
Query: 89 MLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHEVIQ 268
ML +G I + GV LP+ I++ +V + F F P S+
Sbjct: 729 MLILGSIAAVLNGVILPIFGILISSVIKAF------FKPPEQLKSDTRFW---------- 772
Query: 269 NCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYDK--NTSGTL 442
+ ++ LG Q F + KL R R F V+R E+ W+D+ N+SG +
Sbjct: 773 -AIIFMLLGVASMVVFPAQTIFFSIAGCKLVQRIRSMCFEKVVRMEVGWFDETENSSGAI 831
Query: 443 SNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLF 622
+L + VR GD + Q +A G +AF W L I++++ P + + G
Sbjct: 832 GARLSADAATVRGLVGDALAQTVQNLASVTAGLVIAFVASWQLAFIVLAMLPLIGLNGYI 891
Query: 623 XXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKK 802
A +A + + SIRTV +F +E K Y+ E +TGI++
Sbjct: 892 YMKFMVGFSADAKE----ASQVANDAVGSIRTVASFCAEEKVMKMYKKKCEGPMRTGIRQ 947
Query: 803 SFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQ 982
+ G G F ++++SY +F+ G V G+ +V VFF++ M ++A+ Q+
Sbjct: 948 GIVSGIGFGVSFFVLFSSYAASFYAGARLVDDGKTTFDSVFRVFFALTMAAVAISQSSSL 1007
Query: 983 FATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILK 1162
A AAAS++ VIDR +ID G+ + G I + + F YP+R DV+I +
Sbjct: 1008 SPDSSKASNAAASIFAVIDRESKIDPSDESGRVLDNVKGDIELRHISFKYPSRPDVQIFQ 1067
Query: 1163 GVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVG 1342
+ L + G+T+ALVG SG GKST+I LLQRFY+PD+GQI +D + I+ +K+LRQ G
Sbjct: 1068 DLCLSIRAGKTIALVGESGSGKSTVIALLQRFYDPDSGQITLDGVEIKTLQLKWLRQQTG 1127
Query: 1343 VVSQEPNLFNTSIEQNIRYGR-SDVSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQ 1519
+VSQEP LFN +I NI YG+ D ++ +I A + +NA FI +G +T+VG+RGVQ
Sbjct: 1128 LVSQEPVLFNETIRANIAYGKGGDATETEIVSAAELSNAHGFISGLQQGYDTMVGERGVQ 1187
Query: 1520 MSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLS 1699
+SGGQKQR+AIARA+V++PK+LLLDEATSALDAESE +VQ AL+ RTT+V+AHRLS
Sbjct: 1188 LSGGQKQRVAIARAIVKDPKVLLLDEATSALDAESERVVQDALDRVMVNRTTVVVAHRLS 1247
Query: 1700 TVRNADKIIVMKAGQVMEVGTHETLIEQK-GLYHELVHAQVFA 1825
T++NAD I V+K G ++E G HETLI K G+Y LV + A
Sbjct: 1248 TIKNADVIAVVKNGVIVEKGKHETLINIKDGVYASLVQLHLSA 1290
>gi|25146777|ref|NP_509811.2| P-GlycoProtein related (pgp-8)
[Caenorhabditis elegans]
gi|22265670|emb|CAA94203.2| Hypothetical protein T21E8.3
[Caenorhabditis elegans]
gi|22265925|emb|CAA94221.2| Hypothetical protein T21E8.3
[Caenorhabditis elegans]
Length = 1243
Score = 848 bits (2191), Expect = 0.0
Identities = 482/1244 (38%), Positives = 718/1244 (56%), Gaps = 5/1244 (0%)
Frame = +2
Query: 56 LYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAA 235
+++ TS ++ + +G++ + TG+ P MS G VSQ FV + + + S+
Sbjct: 28 VWQCTSKWEKFLFVIGVVSAICTGLTQPFMSYTFGEVSQAFVRITAAVNNASLDPSDLEK 87
Query: 236 ARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAW 415
A F ++ + + +GC GF+Q S F I + + R R +F +++++ +
Sbjct: 88 AYEMFHADMNNVVIHFGLVGCAFMFFGFIQFSLFKYIGDNTTYRLRHKFILRLLKKDAKY 147
Query: 416 YDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLS 595
+D ++G LS L DNLER RE +K+ F G A+AF W L +
Sbjct: 148 FDTISTGYLSTVLNDNLERFREAFNEKIAFIICFSTDFAIGTALAFYTSWTLASYGSVFA 207
Query: 596 PFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALE 775
++I GL Y+ AG IA + L S +TVI+ NGQ E ++Y L+
Sbjct: 208 FGIVISGLLNSTSMMKSNEKQSMHYSNAGAIAFQALCSFKTVISLNGQTQELEKYSAELK 267
Query: 776 HGKKTGIKKSFLIGA--GLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMM 949
G+K G +++F + GL+ FF L +VG + +Y+ + + ++T+F ++
Sbjct: 268 EGEKFGSRRAFFLATSRGLSHFFCNALNGTIL--YVGADLIYNKTMNTVAIVTLFHYMLF 325
Query: 950 GSMALGQAGQQFATIGTALGAAASLYEVI---DRIPEIDAYSTEGQTPSKISGRISVNKV 1120
+ +LG+A + + A+ +A +++V+ D + E + + + + I G +S N V
Sbjct: 326 SAFSLGEAFLHISYLLNAINSATPIFDVLTSDDDMIENNQDNEQTDSNKTIQGMLSFNNV 385
Query: 1121 EFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIP 1300
+F YP+R DV IL+G+S D + G+ +ALVG+SG GKSTI+QLL FYN +G I I D
Sbjct: 386 KFAYPSRPDVDILRGISFDVKQGECIALVGASGSGKSTIVQLLLHFYNIQSGTIKIGDSH 445
Query: 1301 IEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFP 1480
+ D N+K LR +GVVSQEP LFNT+IE+NIR+G + + +I AL++ANA DF+
Sbjct: 446 LHDINLKQLRNAIGVVSQEPVLFNTTIEENIRFGNPNATSSEIYEALRKANAYDFVCNIK 505
Query: 1481 EGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENAS 1660
+GL T+VG+RG Q+SGGQKQRIAIAR LV+NP ILLLDEATSALD+ SE VQ AL+ AS
Sbjct: 506 DGLKTIVGERGAQLSGGQKQRIAIARVLVKNPAILLLDEATSALDSASERAVQLALKKAS 565
Query: 1661 RGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVDDK 1840
GRTTI+IAHRLST+R+ DKI+VM G++ EVG+HE LI Y LV AQ F D
Sbjct: 566 EGRTTIIIAHRLSTIRHCDKIMVMSNGKIAEVGSHEELISMDREYSNLVRAQFF----DS 621
Query: 1841 PKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXGAV 2020
+E + +K N E + +
Sbjct: 622 QSVEEDINGQGAEEVIQKTPPNLNDGEPLEELLKETSSDIE------------------I 663
Query: 2021 KANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHF 2200
K+N++++LR RP+ IQG P S Q ++ D + + GHF
Sbjct: 664 KSNIWEVLRECRPDAFLLSMAVIGSAIQGCNFPILSQIIVQTYKAYAM-DGENILTYGHF 722
Query: 2201 WALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRI 2380
WA MFLVL ++ ++ Q FG +E+L+ R+R K ++++L ++D PKHSP R+
Sbjct: 723 WAAMFLVLGVIRPITLYCQFFFFGKVSEKLSTRLRIKSFQHLLSLPCAFYDDPKHSPTRL 782
Query: 2381 TTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQAL 2560
RL TD NIK+A+D RLGS+ ++ S + IA YY W++ V+ FP + + L
Sbjct: 783 VNRLNTDPSNIKAAVDARLGSLLMSMVSFSLAILIACYYSWKLTLQVVLFFPVLYYAKFL 842
Query: 2561 MMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISK 2740
K S D+ EN+ K A+E ++N++TV+AL ++ ++ N+ +L +
Sbjct: 843 YKKTTTISIKEDSVAFENSNKIAIEVLDNMKTVKALNMEARVINLVMEYLAVLKTSYPRR 902
Query: 2741 AIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAA 2920
+++ GL GF+ YA +F+FG +LI K V+ P ++ L +S++ G A
Sbjct: 903 SVVMGLANGFSAGCSQIVYAISFKFGTYLILQKEVI--PMDMYLSLITLSYTSNMAGSAI 960
Query: 2921 SYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVFFRYPERPAVPIL 3100
SY P++ KA +AGLIFN+ + + +G+ GEV V F Y +RP +L
Sbjct: 961 SYMPDFRKAIHSAGLIFNLFTYPATMPFNSDTGSRSITKGEVNGENVKFHYHQRPDYTVL 1020
Query: 3101 QGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHI 3280
+N+ V+ G+TLA+VGPSG GKST+ISLLE Y +G + +DN+++ +N HLR ++
Sbjct: 1021 DSVNLKVEAGKTLAIVGPSGSGKSTIISLLEMFYRADQGFIKIDNDNVENINLDHLRSNL 1080
Query: 3281 ALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKG 3460
LVSQ P+LF+ SIR+NI+YGL + +IE A AN F+ +LP G +T VG++G
Sbjct: 1081 GLVSQGPVLFNCSIRDNILYGLTRN-ISQTEIENALQIANAFNFVFQLPQGLDTIVGDRG 1139
Query: 3461 TQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHR 3640
QLSGGQKQRIAI RA++RNPK+LLLDEATSALDTESEK VQ ALD A++ + IVVAHR
Sbjct: 1140 AQLSGGQKQRIAITRAILRNPKLLLLDEATSALDTESEKIVQNALDTASERLSTIVVAHR 1199
Query: 3641 LSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSSN 3772
LSTI+NA I V++NG+VVEQGTHN+L+A +G Y+ L Q Q S+
Sbjct: 1200 LSTIINADSIAVLRNGKVVEQGTHNQLLAVKGDYWRLVQHQKSS 1243
>gi|39587992|emb|CAE57223.1| Hypothetical protein CBG00086
[Caenorhabditis briggsae]
Length = 1316
Score = 847 bits (2189), Expect = 0.0
Identities = 470/1267 (37%), Positives = 713/1267 (56%), Gaps = 26/1267 (2%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+++ L+R+ D ++L +GI++S +GV P + +I G ++ +
Sbjct: 76 VTLLGLFRFAERRDHIILLIGILLSFLSGVAQPGLGVIAGGMTNTLIVYNV--------- 126
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
+F + N + +G + F+Q CF +C ++ + R ++ S++R
Sbjct: 127 -----TSPQFLDSALMNVYLFGGIGVVVLIINFIQYMCFQNVCIRIVTKLREEYIKSILR 181
Query: 401 QEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLI 580
Q W+DKN SGTL+ KL DN+ER+ EG GDK+G+ + + F G ++ Y+W L L+
Sbjct: 182 QNAGWFDKNHSGTLTTKLHDNMERIHEGIGDKLGVLIRGIVMFGTGIVISLFYEWRLALM 241
Query: 581 MMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRY 760
MM + P IC AG IAEE L +RTV AFNGQE RY
Sbjct: 242 MMGIGPLCCICMSLMSRSMSSYTSKELADVGKAGSIAEESLMGVRTVQAFNGQEEMVGRY 301
Query: 761 EDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRL-------ESGT 919
L GK +KK L G F++I +Y G Y G+L G
Sbjct: 302 TAELGKGKSYAVKKG-LWGGFFGGIFLLILFTY-----FGGGIFYGGQLLRWKIIENPGD 355
Query: 920 VLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISG 1099
V V FS+++G+ LG + A AAA++YEVIDR+PEIDAYS EGQ KI G
Sbjct: 356 VFIVVFSMLIGAYFLGLISPHLMVLLNARVAAATIYEVIDRVPEIDAYSNEGQKIDKIVG 415
Query: 1100 RISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQ 1279
R+ V F YPTR K+L G++L +PG +VALVG SGCGKST + LL R Y + G+
Sbjct: 416 RVVFENVHFRYPTRKKAKVLNGLNLTIEPGTSVALVGHSGCGKSTSVGLLTRLYEQEDGK 475
Query: 1280 ILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAA 1459
++ID + + NI +LR++VG+V QEP LF+ +I N+ G + + +D+ R K ANA
Sbjct: 476 VMIDGHEVRNLNIDWLRKVVGIVQQEPILFSGTIHNNLLIGNPNATRDDMIRVCKMANAH 535
Query: 1460 DFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQ 1639
+FI P+G +T++GD GVQ+SGGQKQR+AIAR L+R+PK+LLLDEATSALDA+SES+VQ
Sbjct: 536 EFILKMPKGYDTVIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESVVQ 595
Query: 1640 SALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQV 1819
SAL NAS+GRTTI+IAHRLST+R ADKI+ ++G ++E GTH+ L+ G Y LV AQ
Sbjct: 596 SALNNASKGRTTIMIAHRLSTIREADKIVFFESGVIVESGTHDELVALGGRYAALVKAQQ 655
Query: 1820 FADVDDKPKKKE--------AERRM-SRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXX 1972
F + D+ E +E++M SRQ S V+ + + ++
Sbjct: 656 FKEADEVDDDVEEDITARIFSEKQMPSRQVSYHGSCVSLASADLEIGYASAFNSFNLKQA 715
Query: 1973 -------XXXXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSL 2131
G + + + I + A+ + Y +++G+ + ++
Sbjct: 716 QDDIENEDFAEEVQRVMEEDGVITSGYYDIFKNAKGNYWYLSMGTVFAIMRGSELALLAI 775
Query: 2132 FFSQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSK 2311
F + F PD +M ++ +++ L + + +LF + AE L ++ R +
Sbjct: 776 MFGYVFEAFEKPDA-EMARELVIIFILYGCLGLYVFITQVLSSTLFTIVAENLGLKFRVQ 834
Query: 2312 VYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAF 2491
++N+L QDA++FD P H+PG++ TRLATDAPN+K+ +D R+ + ++ S+ L +
Sbjct: 835 SFKNLLYQDASFFDNPAHAPGKLITRLATDAPNVKAVVDTRMLQVIYSMTSITINLVTGY 894
Query: 2492 YYGWQMAF---LVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQ 2662
WQ+A +++A+F + + M Y + + AGK A+E +EN++T+Q
Sbjct: 895 ACCWQIAVVGTVMIALFALLMIS----MAYKIARVNLKQIKRDEAGKIAIEIVENVKTIQ 950
Query: 2663 ALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKN 2842
LT + + L+ H + KA I+ L + + +F + G L++ N
Sbjct: 951 LLTSTEHFLTEYTTALELQHKSEMKKAYIQALNNAISQTFMYFAMFVCYAVGTPLMY--N 1008
Query: 2843 VLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGT 3022
+++P R + ++ + ++ FPE++KA AAG++F ++ +P+ G G
Sbjct: 1009 GIVDPNGAFRAINSMMMGSVAVMHSSHNFPEFVKAKTAAGMLFKLIYRKPK-TGDVMKGN 1067
Query: 3023 YPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLY 3202
+ G + V F YP+RP P++ L+ + GQT+ALVGPSG GKST I++LER Y
Sbjct: 1068 QLDIRGNILFESVKFSYPQRPLHPVMTDLHFTARNGQTVALVGPSGTGKSTCIAMLERFY 1127
Query: 3203 DPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIET 3382
D GA+ +D D++ ++ HLR +ALV QEP LF +IREN+ +GL+ + E++
Sbjct: 1128 DVSGGALRIDGQDIKTLSLHHLRTQMALVGQEPRLFAGTIRENVCFGLK--DVPIEKVNQ 1185
Query: 3383 ACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALD 3562
A AN +F+ LP G +T VGEKG+QLSGGQKQRIAIARAL+R+PKILLLDEATSALD
Sbjct: 1186 ALELANASRFLANLPSGIDTEVGEKGSQLSGGQKQRIAIARALVRDPKILLLDEATSALD 1245
Query: 3563 TESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAY 3742
+ESE+ +Q ALD A + RTCI +AHRLS+I N+ I+ + G+V E G HN L++ RG Y
Sbjct: 1246 SESERVMQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDQGKVQEAGNHNHLMSLRGKY 1305
Query: 3743 FALTQKQ 3763
+ L +KQ
Sbjct: 1306 YDLIKKQ 1312
Score = 333 bits (853), Expect = 2e-89
Identities = 191/510 (37%), Positives = 293/510 (57%), Gaps = 4/510 (0%)
Frame = +2
Query: 2285 RLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIAS 2464
R+ ++R + +++LRQ+A +FD K+ G +TT+L + I I +LG + I
Sbjct: 166 RIVTKLREEYIKSILRQNAGWFD--KNHSGTLTTKLHDNMERIHEGIGDKLGVLIRGIVM 223
Query: 2465 VGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIE 2644
G G+ I+ +Y W++A ++M I P + +LM + + + ++ AG A E++
Sbjct: 224 FGTGIVISLFYEWRLALMMMGIGPLCCICMSLMSRSMSSYTSKELADVGKAGSIAEESLM 283
Query: 2645 NIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLF 2824
+RTVQA Q ++ + + L G S A+ +GL GF I F G+F
Sbjct: 284 GVRTVQAFNGQEEMVGRYTAEL----GKGKSYAVKKGLWGGFFGGIFLLILFTYFGGGIF 339
Query: 2825 L---IFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPR 2995
+ ++ P +V V+F++ +G + + + A AA I+ +++ P
Sbjct: 340 YGGQLLRWKIIENPGDVFIVVFSMLIGAYFLGLISPHLMVLLNARVAAATIYEVIDRVPE 399
Query: 2996 IDGMTSSGT-YPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKS 3172
ID ++ G ++ G V V FRYP R +L GLN+ ++PG ++ALVG SGCGKS
Sbjct: 400 IDAYSNEGQKIDKIVGRVVFENVHFRYPTRKKAKVLNGLNLTIEPGTSVALVGHSGCGKS 459
Query: 3173 TVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQP 3352
T + LL RLY+ +G V +D +++R +N LRK + +V QEPILF +I N++ G P
Sbjct: 460 TSVGLLTRLYEQEDGKVMIDGHEVRNLNIDWLRKVVGIVQQEPILFSGTIHNNLLIG-NP 518
Query: 3353 GEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKIL 3532
T + + C AN H+FI ++P GY+T +G+ G QLSGGQKQR+AIAR LIR+PK+L
Sbjct: 519 NA-TRDDMIRVCKMANAHEFILKMPKGYDTVIGDGGVQLSGGQKQRVAIARTLIRDPKVL 577
Query: 3533 LLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTH 3712
LLDEATSALD +SE VQ AL+ A+K RT I++AHRLSTI A I+ ++G +VE GTH
Sbjct: 578 LLDEATSALDAQSESVVQSALNNASKGRTTIMIAHRLSTIREADKIVFFESGVIVESGTH 637
Query: 3713 NELIAKRGAYFALTQKQSSNQSGGAFDTSE 3802
+EL+A G Y AL + Q ++ D E
Sbjct: 638 DELVALGGRYAALVKAQQFKEADEVDDDVE 667
>gi|47225422|emb|CAG11905.1| unnamed protein product [Tetraodon
nigroviridis]
Length = 1243
Score = 845 bits (2183), Expect = 0.0
Identities = 513/1297 (39%), Positives = 700/1297 (53%), Gaps = 64/1297 (4%)
Frame = +2
Query: 80 DRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHE 259
D LM+ VG +++ G PLM I+ G ++ +F+ + + N + A + +
Sbjct: 20 DILMITVGTLMAIVNGTVNPLMCIVFGQMTDSFIQDARLTKNHNIS---NPRANSTLEED 76
Query: 260 VIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYDKNTSGT 439
+ + + Y LG + +LQ S + + + R R +FFHS+M+QEI+W+D N G
Sbjct: 77 MQRFSMYYSILGFVVLVVAYLQMSLWTLTAGRQVKRIRERFFHSIMQQEISWFDVNEIGE 136
Query: 440 LSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGL 619
L+ +L D++ +++EG GDKVGL Q + FI F + F W LTL++++L
Sbjct: 137 LNTRLTDDVYKIQEGIGDKVGLLIQASSTFITSFIIGFVDGWKLTLVILAL--------- 187
Query: 620 FXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIK 799
YA AG +AEEVL++IRTV AF+GQ K+Y LE + GIK
Sbjct: 188 -----LTSFTSKEQTAYAKAGAVAEEVLSAIRTVFAFSGQNKAIKKYHKNLEDARDMGIK 242
Query: 800 KSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQ 979
K A F++IY SY LAFW GT V + G +LTV G
Sbjct: 243 KGVAANAATGFTFLMIYLSYALAFWYGTTLVLNQEYTIGNLLTV------------SGGG 290
Query: 980 QFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKIL 1159
T ++ A P ID++S +G P I G I + F+YP+R +V+IL
Sbjct: 291 TIETNHQSVAAETK--------PNIDSFSEDGFKPDYIKGDIEFKNIHFSYPSRPEVQIL 342
Query: 1160 KGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLV 1339
+SL + GQT+ALVGSSGCGKST IQLLQRFY+P G I ID I NI+YLR+++
Sbjct: 343 NDMSLHVRNGQTMALVGSSGCGKSTTIQLLQRFYDPQKGSIFIDGHDIRSLNIRYLREMI 402
Query: 1340 GVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQ 1519
GVVSQEP LF T+I +NIRYGR DV+ E+I RA KE+NA DFI + P+ TLVGDRG Q
Sbjct: 403 GVVSQEPILFATTIAENIRYGRLDVTQEEIERATKESNAYDFIMSLPDKFETLVGDRGTQ 462
Query: 1520 MSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLS 1699
+SGGQKQRIAIARALVRNPKILLLDEATSALDAESE+IVQ+AL+ GRTTIVIAHRLS
Sbjct: 463 LSGGQKQRIAIARALVRNPKILLLDEATSALDAESETIVQAALDKVRLGRTTIVIAHRLS 522
Query: 1700 TVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVDDKP-KKKEAERRMSR 1876
T+RNAD I G+++E+GTH L+E++G+YH LV Q+F ++D+ E
Sbjct: 523 TIRNADIIAGFSKGEIVELGTHSQLMEKQGVYHGLVTMQIFQQMEDQEVSDSELSAAERS 582
Query: 1877 QTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXGAVKANLFKILRYAR 2056
Q + + + S A + FK++R+
Sbjct: 583 QLIKSFSQSSLHRRRSTRGSSFVSEGTKEERETFECDQDNSEEDEKAPPVSFFKVMRFNI 642
Query: 2057 PEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQ 2236
EW Y +I GA+ P FS+ F++II F
Sbjct: 643 SEWPYILVGTICAVITGAMQPVFSIIFTEIIVGF-------------------------- 676
Query: 2237 GTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIK 2416
F + E LT+ +R K + +++RQD +++D PK++ G +TTRL+ DA ++
Sbjct: 677 ---------CFSKSGEILTLNLRLKAFTSMMRQDLSWYDNPKNTVGALTTRLSADAAQVQ 727
Query: 2417 SAIDYRLGSIFNAIASVGGG----LGIAFYYGWQMAFLVMAIFPFMAVGQALM------- 2563
+ GG G ++ + + P G A
Sbjct: 728 GVSGIGDAMLDTGRRRASGGDHAEHGQPGHWHHHQLRVWLGADPAHPGGGAHSGGGRSRR 787
Query: 2564 ------MKYHGGSATSDAKE---MENAGKTAME--------------AIENIRTVQALTL 2674
+ G T ++++ + +G++ ++ A+ NIRTV +L
Sbjct: 788 GEAAHGTRCRGQEGTGESRKGICSQGSGESVLDLLHPECFILQIATEAMVNIRTVVSLAR 847
Query: 2675 QTKLYNIFCSHLDAPH---GGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNV 2845
+ ++ +L P+ + KA I GLTY F ++ FF YAA+FRFG +LI +
Sbjct: 848 EPTFEALYIENLSVPYKYETNSRKKANIYGLTYSFCQAMIFFVYAASFRFGAWLIEAGRM 907
Query: 2846 LMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTY 3025
M E V V+ I + +G A +Y P Y KA AA + ++ +P +D ++ G
Sbjct: 908 TM--EGVFLVVMTILYGAMAVGEANTYAPNYAKAKLAASHLMMLIYRKPLVDNLSEEGAS 965
Query: 3026 PQ-LSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLY 3202
P+ G V V F YP RP VPILQGLN+ V+ G+TLALVG SGCGKST I LLER Y
Sbjct: 966 PEKYDGNVLFEHVKFNYPSRPDVPILQGLNLKVQKGETLALVGSSGCGKSTTIQLLERFY 1025
Query: 3203 DPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIET 3382
DP EG V +D+ D +++N + LR + +VSQEP+LFD S+ ENI YG ++I
Sbjct: 1026 DPREGRVLLDSVDTKELNIRWLRSQMGIVSQEPVLFDCSLAENIAYGDNSRSVAMDEIVA 1085
Query: 3383 ACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALD 3562
A ANIH FID LP Y+T+ G+KGTQLSGGQKQRIAIARA+IRNPK+LLLDEATSALD
Sbjct: 1086 AAKAANIHSFIDGLPQKYDTQAGDKGTQLSGGQKQRIAIARAIIRNPKLLLLDEATSALD 1145
Query: 3563 TESEK-------------------------QVQVALDAAAKDRTCIVVAHRLSTIVNAGC 3667
TESEK VQ ALD A K RTCIVVAHRLSTI NA C
Sbjct: 1146 TESEKVSGDSPWVHLTDPSGLYRAGDSRLQVVQEALDQARKGRTCIVVAHRLSTIQNADC 1205
Query: 3668 IMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSSNQS 3778
I V + G VVE+GTH +LIAK+G Y L KQ + +
Sbjct: 1206 IAVFQGGVVVEKGTHQQLIAKKGVYHMLVTKQMGHNA 1242
>gi|39587990|emb|CAE57221.1| Hypothetical protein CBG00083
[Caenorhabditis briggsae]
Length = 1301
Score = 839 bits (2167), Expect = 0.0
Identities = 490/1278 (38%), Positives = 717/1278 (55%), Gaps = 37/1278 (2%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+S+ QL+R+ + D ++L +G++ S +GV P+++II G ++ + + DP S
Sbjct: 54 VSLLQLFRFATPFDYILLIIGVVTSIISGVSQPVLAIISGRLTNVLLVV-----DPLSK- 107
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAA--GFLQASCFMVICEKLSNRFRRQFFHSV 394
EF ++ ++N Y++LG GIF + F Q CF +C ++ + R ++ S+
Sbjct: 108 --------EFKNKAMENV--YIFLGLGIFVSINDFCQYMCFQRVCSRMMTQMRNRYISSI 157
Query: 395 MRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLT 574
+RQ W+DKN SGT++ +L DN+ER+++G GDK+G+ + ++ + ++ Y+W L
Sbjct: 158 LRQNAGWFDKNLSGTITTRLNDNMERIQDGVGDKLGVLIRGISMVLTSVIISLVYEWRLA 217
Query: 575 LIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECK 754
L+M+ L P IC + +AG IAEE L +RT+ AFNGQE
Sbjct: 218 LMMVGLIPVSTICMTLLSRFLEKSTGEELEKVGIAGAIAEESLMGVRTIQAFNGQEEMVA 277
Query: 755 RYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRL-------ES 913
+YE L GK+ I IG + FF ++ + LAF +G +Y G L
Sbjct: 278 KYEKHLNSGKRHAI-----IGGFWSGFFGGMFFFWLLAF-MGCGILYGGYLLKVGIIKSP 331
Query: 914 GTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKI 1093
G V + ++++G+ LG + A AAAS+Y+ IDR+P+ID YS G+ ++
Sbjct: 332 GDVFIIIMAMLLGAYFLGLISPHLMVLLNARVAAASIYKTIDRVPKIDPYSKAGKKLDRV 391
Query: 1094 SGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDA 1273
G+++ V F YPTR + K+L G+ L +PG +VALVG SGCGKST + LL R Y P+
Sbjct: 392 VGKVTFRNVHFRYPTRKEAKVLNGLDLTVEPGTSVALVGHSGCGKSTSVGLLTRLYEPED 451
Query: 1274 GQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEAN 1453
G + ID + + D N+ +LR +VG+V QEP LFN +I N+ G D + E + K AN
Sbjct: 452 GSVQIDGVDVRDLNMDWLRNIVGIVQQEPILFNDTIHNNLLIGNPDATREKMIEVCKMAN 511
Query: 1454 AADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESI 1633
A DFIK P+G +TL+GD GVQ+SGGQKQR+AIAR L+R+PKILLLDEATSALDA+SES+
Sbjct: 512 AHDFIKKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKILLLDEATSALDAQSESV 571
Query: 1634 VQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHA 1813
VQSAL NA+RGRTTI+IAHRLST+R ADKI+ + G ++E G H L+ G Y+ LV A
Sbjct: 572 VQSALNNAARGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHGELVALGGRYYNLVKA 631
Query: 1814 QVF----------ADVDDKPKKKEAERRMSRQ-------TSQRKGSVNFK----TQESQV 1930
Q F A+ +D+ + E +RQ +S R GS F+ S
Sbjct: 632 QQFKQDPEDIELEAEQEDQFDEFEKPTMFTRQVSTRSSRSSGRSGSDEFRRGTLANHSFD 691
Query: 1931 DXXXXXXXXXXXXXXXXXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGA 2110
V A I + A + Y LI+G
Sbjct: 692 RFRKPSHVPTAEDEAFALKVKETMEKDEEVTAGYLDIFKNAHGNYGYMFIGLVAALIRGL 751
Query: 2111 VMPAFSLFFSQIINVFS-NPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQ---CSLFGVA 2278
+PAF+L S + F P +M H + + + V FQ +F +
Sbjct: 752 DLPAFALLLSWVFEGFEFVPYGGKMM---HRFVMSVIAHCGVGLGIWFFQTLSTVMFAIV 808
Query: 2279 AERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAI 2458
+E L +R R +RN+L QD+ YFD P H+PG + TRLA D P++K+ +D R+ + A
Sbjct: 809 SENLGVRFRVDAFRNLLYQDSAYFDNPAHAPGSLITRLAADPPSVKAVVDGRMMQVIYAF 868
Query: 2459 ASVGGGLGIAFYYGWQMAFL---VMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTA 2629
++V + I F Y WQ+A L ++ F+ G A + + + ++AGK A
Sbjct: 869 SAVVACVTIGFIYCWQVAILGTSLIFFLGFVMCGLAFKITI----LAVEHMQNDDAGKVA 924
Query: 2630 MEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAF 2809
+E IEN++T+Q LT + N + + + K++ + Y + F Y + F
Sbjct: 925 IEIIENVKTIQLLTRTKRFLNSYENESKKRKTTELRKSVFEAINYSITQN--FMYYMSCF 982
Query: 2810 RFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEE 2989
F L + + R L A+ I +A +FP+++ A AAG +FN++ +
Sbjct: 983 CFALAIRVINEGDQPVDKTFRSLMAMMLCCEGIILSAQFFPQFVGAKSAAGQMFNLIYRK 1042
Query: 2990 PRIDGMTSSGTYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGK 3169
P+ G +G+ P++ G + V F YP+RP P+++ L GQT+A+VGPSG GK
Sbjct: 1043 PQ-TGDVKTGSQPEIRGNILFENVKFSYPQRPHQPVMKTLQWTALRGQTVAIVGPSGSGK 1101
Query: 3170 STVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQ 3349
ST IS+LER YD GA+ +D D+R M+ HLR +ALV QEP LF +IRENI GL+
Sbjct: 1102 STCISMLERFYDVTGGALRIDGQDIRTMSLYHLRTQMALVGQEPRLFVGTIRENICLGLK 1161
Query: 3350 PGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKI 3529
+ E+I A AN ++F+ LP G +T VGE+G QLSGGQKQRIAIARAL+R+PKI
Sbjct: 1162 --DVPLEKINQALELANANRFLGNLPAGIDTEVGERGGQLSGGQKQRIAIARALVRDPKI 1219
Query: 3530 LLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGT 3709
LLLDEATSALD+ESEK VQ ALD A + RTCI +AHRLS+I N+ I+ + +G+V E GT
Sbjct: 1220 LLLDEATSALDSESEKAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDDGRVQEAGT 1279
Query: 3710 HNELIAKRGAYFALTQKQ 3763
HNEL+ +G YF L +KQ
Sbjct: 1280 HNELMHMKGKYFELIKKQ 1297
Score = 336 bits (862), Expect = 2e-90
Identities = 203/590 (34%), Positives = 321/590 (54%), Gaps = 7/590 (1%)
Frame = +2
Query: 2027 NLFKILRYARP-EWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFS--NPDRDQMKKDGH 2197
+L ++ R+A P ++I +I G P ++ ++ NV +P + K
Sbjct: 55 SLLQLFRFATPFDYILLIIGVVTSIISGVSQPVLAIISGRLTNVLLVVDPLSKEFKNKAM 114
Query: 2198 FWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGR 2377
+FL L + Q F R+ ++R++ ++LRQ+A +FD K+ G
Sbjct: 115 ENVYIFLGLGIFVSINDFCQYMCFQRVCSRMMTQMRNRYISSILRQNAGWFD--KNLSGT 172
Query: 2378 ITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQA 2557
ITTRL + I+ + +LG + I+ V + I+ Y W++A +++ + P +
Sbjct: 173 ITTRLNDNMERIQDGVGDKLGVLIRGISMVLTSVIISLVYEWRLALMMVGLIPVSTICMT 232
Query: 2558 LMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNIS 2737
L+ ++ S + +++ AG A E++ +RT+QA Q ++ + HL++
Sbjct: 233 LLSRFLEKSTGEELEKVGIAGAIAEESLMGVRTIQAFNGQEEMVAKYEKHLNSGK----R 288
Query: 2738 KAIIRGLTYGFANSIQFFTYAAAFRFGLFL---IFDKNVLMEPENVLRVLFAISFSFGTI 2908
AII G GF + FF A G+ + ++ P +V ++ A+ +
Sbjct: 289 HAIIGGFWSGFFGGMFFFWLLAFMGCGILYGGYLLKVGIIKSPGDVFIIIMAMLLGAYFL 348
Query: 2909 GFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGT-YPQLSGEVKLNKVFFRYPERP 3085
G + + + A AA I+ ++ P+ID + +G ++ G+V V FRYP R
Sbjct: 349 GLISPHLMVLLNARVAAASIYKTIDRVPKIDPYSKAGKKLDRVVGKVTFRNVHFRYPTRK 408
Query: 3086 AVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKH 3265
+L GL++ V+PG ++ALVG SGCGKST + LL RLY+P +G+V +D D+R +N
Sbjct: 409 EAKVLNGLDLTVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEDGSVQIDGVDVRDLNMDW 468
Query: 3266 LRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETR 3445
LR + +V QEPILF+ +I N++ G + T E++ C AN H FI ++P GY+T
Sbjct: 469 LRNIVGIVQQEPILFNDTIHNNLLIGNP--DATREKMIEVCKMANAHDFIKKMPKGYDTL 526
Query: 3446 VGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCI 3625
+G+ G QLSGGQKQR+AIAR LIR+PKILLLDEATSALD +SE VQ AL+ AA+ RT I
Sbjct: 527 IGDGGVQLSGGQKQRVAIARTLIRDPKILLLDEATSALDAQSESVVQSALNNAARGRTTI 586
Query: 3626 VVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSSNQ 3775
++AHRLSTI A I+ + G +VE G H EL+A G Y+ L + Q Q
Sbjct: 587 MIAHRLSTIREADKIVFFEKGVIVEAGNHGELVALGGRYYNLVKAQQFKQ 636
Score = 291 bits (744), Expect = 1e-76
Identities = 189/580 (32%), Positives = 292/580 (49%), Gaps = 4/580 (0%)
Frame = +2
Query: 98 VGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHEVIQNCL 277
+G++ + G+ LP ++++ V + F E + H + + +
Sbjct: 741 IGLVAALIRGLDLPAFALLLSWVFEGF---------------EFVPYGGKMMHRFVMSVI 785
Query: 278 KYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYDK--NTSGTLSNK 451
+ +G GI+ L F ++ E L RFR F +++ Q+ A++D + G+L +
Sbjct: 786 AHCGVGLGIWFFQTLSTVMFAIVSENLGVRFRVDAFRNLLYQDSAYFDNPAHAPGSLITR 845
Query: 452 LFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFM--MICGLFX 625
L + V+ ++ + + + F Y W + ++ SL F+ ++CGL
Sbjct: 846 LAADPPSVKAVVDGRMMQVIYAFSAVVACVTIGFIYCWQVAILGTSLIFFLGFVMCGL-- 903
Query: 626 XXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKS 805
Q AG +A E++ +++T+ + YE+ + K T ++KS
Sbjct: 904 -AFKITILAVEHMQNDDAGKVAIEIIENVKTIQLLTRTKRFLNSYENESKKRKTTELRKS 962
Query: 806 FLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQF 985
+ +Y C F + + G ++M+ + + Q F
Sbjct: 963 VFEAINYSITQNFMYYMSCFCFALAIRVINEGDQPVDKTFRSLMAMMLCCEGIILSAQFF 1022
Query: 986 ATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKG 1165
A AA ++ +I R P+ T Q +I G I V+F+YP R ++K
Sbjct: 1023 PQFVGAKSAAGQMFNLIYRKPQTGDVKTGSQP--EIRGNILFENVKFSYPQRPHQPVMKT 1080
Query: 1166 VSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGV 1345
+ A GQTVA+VG SG GKST I +L+RFY+ G + ID I ++ +LR + +
Sbjct: 1081 LQWTALRGQTVAIVGPSGSGKSTCISMLERFYDVTGGALRIDGQDIRTMSLYHLRTQMAL 1140
Query: 1346 VSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQMS 1525
V QEP LF +I +NI G DV E I +AL+ ANA F+ P G++T VG+RG Q+S
Sbjct: 1141 VGQEPRLFVGTIRENICLGLKDVPLEKINQALELANANRFLGNLPAGIDTEVGERGGQLS 1200
Query: 1526 GGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLSTV 1705
GGQKQRIAIARALVR+PKILLLDEATSALD+ESE VQ AL+ A GRT I IAHRLS++
Sbjct: 1201 GGQKQRIAIARALVRDPKILLLDEATSALDSESEKAVQEALDRAREGRTCITIAHRLSSI 1260
Query: 1706 RNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFA 1825
+N+D I+ + G+V E GTH L+ KG Y EL+ Q A
Sbjct: 1261 QNSDLIVYIDDGRVQEAGTHNELMHMKGKYFELIKKQDLA 1300
>gi|7511495|pir||T18940 multidrug resistance protein homolog -
Caenorhabditis elegans
Length = 1238
Score = 837 bits (2162), Expect = 0.0
Identities = 479/1244 (38%), Positives = 715/1244 (56%), Gaps = 5/1244 (0%)
Frame = +2
Query: 56 LYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAA 235
+++ TS ++ + +G++ + TG+ P MS G VSQ FV + + + S+
Sbjct: 28 VWQCTSKWEKFLFVIGVVSAICTGLTQPFMSYTFGEVSQAFVRITAAVNNASLDPSDLEK 87
Query: 236 ARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAW 415
A F ++ + + +GC GF+Q S F I + + R R +F +++++ +
Sbjct: 88 AYEMFHADMNNVVIHFGLVGCAFMFFGFIQFSLFKYIGDNTTYRLRHKFILRLLKKDAKY 147
Query: 416 YDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLS 595
+D ++G LS L DNLER RE +K+ F G A+AF W L +
Sbjct: 148 FDTISTGYLSTVLNDNLERFREAFNEKIAFIICFSTDFAIGTALAFYTSWTLASYGSVFA 207
Query: 596 PFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALE 775
++I GL Y+ AG IA + L S +TVI+ NGQ E ++Y L+
Sbjct: 208 FGIVISGLLNSTSMMKSNEKQSMHYSNAGAIAFQALCSFKTVISLNGQTQELEKYSAELK 267
Query: 776 HGKKTGIKKSFLIGA--GLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMM 949
G+K G +++F + GL+ FF L +VG + +Y+ + + ++T+F ++
Sbjct: 268 EGEKFGSRRAFFLATSRGLSHFFCNALNGTIL--YVGADLIYNKTMNTVAIVTLFHYMLF 325
Query: 950 GSMALGQAGQQFATIGTALGAAASLYEVI---DRIPEIDAYSTEGQTPSKISGRISVNKV 1120
+ +LG+A + + A+ +A +++V+ D + E + + + + I G +S N V
Sbjct: 326 SAFSLGEAFLHISYLLNAINSATPIFDVLTSDDDMIENNQDNEQTDSNKTIQGMLSFNNV 385
Query: 1121 EFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIP 1300
+F YP+R DV IL+G+S D + G+ +ALVG+SG GKSTI+QLL FYN +G I I D
Sbjct: 386 KFAYPSRPDVDILRGISFDVKQGECIALVGASGSGKSTIVQLLLHFYNIQSGTIKIGDSH 445
Query: 1301 IEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFP 1480
+ D N+K LR +GVVSQEP LFNT+IE+NIR+G + + +I AL++ANA DF+
Sbjct: 446 LHDINLKQLRNAIGVVSQEPVLFNTTIEENIRFGNPNATSSEIYEALRKANAYDFVCNIK 505
Query: 1481 EGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENAS 1660
+GL T+VG+RG Q+SGGQKQRIAIAR LV+NP ILLLDEATSALD+ SE VQ AL+ AS
Sbjct: 506 DGLKTIVGERGAQLSGGQKQRIAIARVLVKNPAILLLDEATSALDSASERAVQLALKKAS 565
Query: 1661 RGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVDDK 1840
GRTTI+IAHRLST+R+ DKI+VM G++ EVG+HE LI Y LV AQ F D
Sbjct: 566 EGRTTIIIAHRLSTIRHCDKIMVMSNGKIAEVGSHEELISMDREYSNLVRAQFF----DS 621
Query: 1841 PKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXGAV 2020
+E + +K N E + +
Sbjct: 622 QSVEEDINGQGAEEVIQKTPPNLNDGEPLEELLKETSSDIE------------------I 663
Query: 2021 KANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHF 2200
K+N++++LR RP+ IQG P S Q ++ D + + GHF
Sbjct: 664 KSNIWEVLRECRPDAFLLSMAVIGSAIQGCNFPILSQIIVQTYKAYAM-DGENILTYGHF 722
Query: 2201 WALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRI 2380
WA MFLVL ++ ++ Q FG +E+L+ R+R K ++++L ++D PKHSP R+
Sbjct: 723 WAAMFLVLGVIRPITLYCQFFFFGKVSEKLSTRLRIKSFQHLLSLPCAFYDDPKHSPTRL 782
Query: 2381 TTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQAL 2560
RL TD NIK+A+D RLGS+ ++ S + IA YY W++ + + + L
Sbjct: 783 VNRLNTDPSNIKAAVDARLGSLLMSMVSFSLAILIACYYSWKLTLQAILYY-----AKFL 837
Query: 2561 MMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISK 2740
K S D+ EN+ K A+E ++N++TV+AL ++ ++ N+ +L +
Sbjct: 838 YKKTTTISIKEDSVAFENSNKIAIEVLDNMKTVKALNMEARVINLVMEYLAVLKTSYPRR 897
Query: 2741 AIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAA 2920
+++ GL GF+ YA +F+FG +LI K V+ P ++ L +S++ G A
Sbjct: 898 SVVMGLANGFSAGCSQIVYAISFKFGTYLILQKEVI--PMDMYLSLITLSYTSNMAGSAI 955
Query: 2921 SYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVFFRYPERPAVPIL 3100
SY P++ KA +AGLIFN+ + + +G+ GEV V F Y +RP +L
Sbjct: 956 SYMPDFRKAIHSAGLIFNLFTYPATMPFNSDTGSRSITKGEVNGENVKFHYHQRPDYTVL 1015
Query: 3101 QGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHI 3280
+N+ V+ G+TLA+VGPSG GKST+ISLLE Y +G + +DN+++ +N HLR ++
Sbjct: 1016 DSVNLKVEAGKTLAIVGPSGSGKSTIISLLEMFYRADQGFIKIDNDNVENINLDHLRSNL 1075
Query: 3281 ALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKG 3460
LVSQ P+LF+ SIR+NI+YGL + +IE A AN F+ +LP G +T VG++G
Sbjct: 1076 GLVSQGPVLFNCSIRDNILYGLTRN-ISQTEIENALQIANAFNFVFQLPQGLDTIVGDRG 1134
Query: 3461 TQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHR 3640
QLSGGQKQRIAI RA++RNPK+LLLDEATSALDTESEK VQ ALD A++ + IVVAHR
Sbjct: 1135 AQLSGGQKQRIAITRAILRNPKLLLLDEATSALDTESEKIVQNALDTASERLSTIVVAHR 1194
Query: 3641 LSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSSN 3772
LSTI+NA I V++NG+VVEQGTHN+L+A +G Y+ L Q Q S+
Sbjct: 1195 LSTIINADSIAVLRNGKVVEQGTHNQLLAVKGDYWRLVQHQKSS 1238
>gi|39594940|emb|CAE70808.1| Hypothetical protein CBG17570
[Caenorhabditis briggsae]
Length = 1402
Score = 833 bits (2153), Expect = 0.0
Identities = 475/1235 (38%), Positives = 716/1235 (57%), Gaps = 3/1235 (0%)
Frame = +2
Query: 56 LYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAA 235
+++ TS +++L+ +G I + TG+ P +S G VS FV + + + SE
Sbjct: 28 VWKCTSKLEKLLFLLGTISAVCTGLCQPFLSYTFGEVSHVFVRITSAVNNRTLDPSELDE 87
Query: 236 ARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAW 415
A F +E+ Q L + +GC GF Q S F + + + R RR++ +++++ +
Sbjct: 88 AYEVFHNEMNQVVLYFALVGCAFAMFGFFQFSLFKYVGDNTTYRVRRKYISRLLQKDAQY 147
Query: 416 YDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLS 595
+D ++G LS L DNLER RE +K+ F+ G +AF DW L +
Sbjct: 148 FDTVSTGYLSTVLNDNLERFREAFNEKIAFIICFSTDFVIGTTLAFYTDWKLASYGSIFA 207
Query: 596 PFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALE 775
+ G YA AG IA + L+S +TVI+ NGQ E +RY L+
Sbjct: 208 LGIAFSGFINSASMMGSTVKQNTHYANAGAIAFQALSSFKTVISLNGQAQELERYSKELK 267
Query: 776 HGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGS 955
G+K G +++F + + A + +VG + +Y+ ++ ++T+F ++ +
Sbjct: 268 AGEKYGARRAFFLATSRSVTHFFCNALNGIILYVGADLIYNKTMDQAVIVTLFHYMLFSA 327
Query: 956 MALGQAGQQFATIGTALGAAASLYEVI---DRIPEIDAYSTEGQTPSKISGRISVNKVEF 1126
+LG+A + + A+ +A+ ++ V+ D I E TE + +I G I + V+F
Sbjct: 328 FSLGEAFPHISYLSNAISSASPIFAVLISKDDIIENHQNDTERDS-ERIEGDIQFDNVKF 386
Query: 1127 TYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIE 1306
+YPTR + + LKGV+ + + G+ VALVG+SG GKSTI+QLL +YN ++G ILIDD+ +
Sbjct: 387 SYPTRPEAQALKGVTFNVKKGECVALVGASGSGKSTIVQLLLHYYNIESGNILIDDVDLN 446
Query: 1307 DFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEG 1486
N+K LR +GVVSQEP LFNT+IE+NIR+G S +I +L+ ANA DF+ +FP+G
Sbjct: 447 KINLKKLRGNIGVVSQEPVLFNTTIEENIRFGNPAASTLEIYDSLRVANAYDFVNSFPKG 506
Query: 1487 LNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRG 1666
+ T+VG+RG Q+SGGQKQRIAIAR LV+NPKILLLDEATSALD +SE +V+ A++ AS+G
Sbjct: 507 IKTVVGERGTQLSGGQKQRIAIARVLVKNPKILLLDEATSALDNQSEHVVRIAMKEASKG 566
Query: 1667 RTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVDDKPK 1846
RTTIVIAHRLST+++ D+IIVM G+ + GTH+ L+E +Y +LV AQ D +
Sbjct: 567 RTTIVIAHRLSTIQHCDRIIVMSHGKTVASGTHDKLMENSIVYKDLVQAQSLNSEDSVVE 626
Query: 1847 KKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXGAVKA 2026
K + TS+ K N + +E D + +
Sbjct: 627 KS----IKTIATSETKHPTNEELEEELKDTPEEE----------------------TMSS 660
Query: 2027 NLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHFWA 2206
+++ILR R IQG P + ++ ++ + + +GHFWA
Sbjct: 661 TIWQILRECRSHCCMLFLAVVGSAIQGFSFPILAQLIVRVYKAYA-MQGEAILVNGHFWA 719
Query: 2207 LMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITT 2386
MFLVL + ++ Q FG E+L+ R+R K ++++L ++D PK+SP R+
Sbjct: 720 SMFLVLGLYRPITLYCQYFFFGKIGEKLSTRLRIKSFQHLLSLPCAFYDDPKNSPTRLAN 779
Query: 2387 RLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMM 2566
RL TDA N+K+A+D RLGS+ + S + IA YY W++ V+ FP + + +
Sbjct: 780 RLNTDASNVKAAVDARLGSVLMTLVSFIVAITIACYYSWKLTIQVLLFFPVLYLSKYCYE 839
Query: 2567 KYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAI 2746
K S D+ E + K A+E ++NI+TV++L ++ K+ ++ L+ +A
Sbjct: 840 KTTVLSIKQDSLAFEFSNKIAIEVLDNIKTVRSLNMEQKVMSMVTGQLEMLKRKYHKRAF 899
Query: 2747 IRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASY 2926
GL GF+ YA +F+FG +LI + VL P ++ L +S++ G A SY
Sbjct: 900 FLGLASGFSAGCSQIVYALSFKFGTYLILQREVL--PMDMYLALVTLSYTSNMAGSAISY 957
Query: 2927 FPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVFFRYPERPAVPILQG 3106
P+Y KA AAGLIFN+ + GT G V V F Y +RP +L+
Sbjct: 958 LPDYKKALHAAGLIFNLFTYPATAPYNSDQGTTNISQGIVNAENVKFHYHQRPDHLVLKN 1017
Query: 3107 LNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIAL 3286
+++H++PG+TLALVGPSG GKST ISLLE Y G + +D+ ++ +N HLR ++AL
Sbjct: 1018 VDLHLEPGKTLALVGPSGSGKSTFISLLEMFYRVNTGHINIDHENVENINLHHLRSNLAL 1077
Query: 3287 VSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQ 3466
VSQEPILF+ SIREN++YGL G + + +ETA AN + F+ ++P+G +T VGE+G Q
Sbjct: 1078 VSQEPILFNCSIRENLLYGLD-GPESDQNLETALETANAYNFVSQMPNGLDTIVGERGAQ 1136
Query: 3467 LSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLS 3646
LSGGQKQR+AIARA++RNPK+LLLDEATSALD++SEK VQ ALD A++ + I+VAHRLS
Sbjct: 1137 LSGGQKQRVAIARAILRNPKLLLLDEATSALDSDSEKLVQTALDTASERLSTIIVAHRLS 1196
Query: 3647 TIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFAL 3751
TIVNA I V+K G+VVEQG+H EL+ +GAY+ L
Sbjct: 1197 TIVNADSIAVLKMGKVVEQGSHEELLKLKGAYWKL 1231
Score = 278 bits (712), Expect = 6e-73
Identities = 191/542 (35%), Positives = 284/542 (52%), Gaps = 11/542 (2%)
Frame = +2
Query: 2207 LMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITT 2386
L F ++ FQ SLF + T R+R K +L++DA YFD S G ++T
Sbjct: 101 LYFALVGCAFAMFGFFQFSLFKYVGDNTTYRVRRKYISRLLQKDAQYFDTV--STGYLST 158
Query: 2387 RLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMA----FLVMAIFPFMAVGQ 2554
L + + A + ++ I G +AFY W++A + I +
Sbjct: 159 VLNDNLERFREAFNEKIAFIICFSTDFVIGTTLAFYTDWKLASYGSIFALGIAFSGFINS 218
Query: 2555 ALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNI 2734
A MM GS NAG A +A+ + +TV +L Q + + L A
Sbjct: 219 ASMM----GSTVKQNTHYANAGAIAFQALSSFKTVISLNGQAQELERYSKELKAGEKYGA 274
Query: 2735 SKAII----RGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFG 2902
+A R +T+ F N++ G LI++K M+ ++ + + FS
Sbjct: 275 RRAFFLATSRSVTHFFCNALN----GIILYVGADLIYNKT--MDQAVIVTLFHYMLFSAF 328
Query: 2903 TIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTY---PQLSGEVKLNKVFFRY 3073
++G A + A +A IF +L + I + T ++ G+++ + V F Y
Sbjct: 329 SLGEAFPHISYLSNAISSASPIFAVLISKDDIIENHQNDTERDSERIEGDIQFDNVKFSY 388
Query: 3074 PERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQM 3253
P RP L+G+ +VK G+ +ALVG SG GKST++ LL Y+ G + +D+ DL ++
Sbjct: 389 PTRPEAQALKGVTFNVKKGECVALVGASGSGKSTIVQLLLHYYNIESGNILIDDVDLNKI 448
Query: 3254 NPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDG 3433
N K LR +I +VSQEP+LF+T+I ENI +G P T E I + AN + F++ P G
Sbjct: 449 NLKKLRGNIGVVSQEPVLFNTTIEENIRFG-NPAASTLE-IYDSLRVANAYDFVNSFPKG 506
Query: 3434 YETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKD 3613
+T VGE+GTQLSGGQKQRIAIAR L++NPKILLLDEATSALD +SE V++A+ A+K
Sbjct: 507 IKTVVGERGTQLSGGQKQRIAIARVLVKNPKILLLDEATSALDNQSEHVVRIAMKEASKG 566
Query: 3614 RTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSSNQSGGAFD 3793
RT IV+AHRLSTI + I+V+ +G+ V GTH++L+ Y L Q QS N +
Sbjct: 567 RTTIVIAHRLSTIQHCDRIIVMSHGKTVASGTHDKLMENSIVYKDLVQAQSLNSEDSVVE 626
Query: 3794 TS 3799
S
Sbjct: 627 KS 628
>gi|17567265|ref|NP_510126.1| P-GlycoProtein related (pgp-12)
[Caenorhabditis elegans]
gi|7499663|pir||T21266 hypothetical protein F22E10.1 - Caenorhabditis
elegans
gi|3876291|emb|CAA91799.1| Hypothetical protein F22E10.1
[Caenorhabditis elegans]
Length = 1318
Score = 833 bits (2152), Expect = 0.0
Identities = 467/1271 (36%), Positives = 713/1271 (55%), Gaps = 30/1271 (2%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+++ L+RY D +L GI +S +G+ P + II GN++ + L N+T+
Sbjct: 76 VTLLGLFRYAERTDYALLCFGIFLSFISGIAQPGLGIIAGNITNSL-------LIHNATS 128
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
+ F + N + +G + F+Q CF C +++++ ++ + S++R
Sbjct: 129 DD-------FYDSAMTNVWLFGGIGIIVLIVNFVQYMCFQYCCIRITSKMKQHYIQSILR 181
Query: 401 QEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLI 580
Q W+DKN SGTL+ KL DN+ER+ EG GDK+G+ + M F+ G ++F Y+W L L+
Sbjct: 182 QNAGWFDKNHSGTLTTKLHDNMERINEGIGDKLGVLIRGMVMFVAGIVISFFYEWRLALM 241
Query: 581 MMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRY 760
MM + P +C AG IAEE L +RTV AFNGQE ++Y
Sbjct: 242 MMGIGPLCCVCMSLMSRSMSSFTSKELAGVGKAGSIAEESLMGVRTVQAFNGQEEMVEKY 301
Query: 761 EDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRL-------ESGT 919
L GK I+K L G F++ SY G Y G+L G
Sbjct: 302 TVELGKGKSFAIQKG-LWGGVFGGIFLLFLFSY-----FGGGIYYGGQLLRWKIIETPGD 355
Query: 920 VLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISG 1099
V V S+++G+ LG + A AAA++YE+IDR P+ID YSTEGQ + + G
Sbjct: 356 VFIVVISMLIGAYFLGLISPHLMVLLNARVAAATIYEIIDRTPDIDVYSTEGQKMTNVVG 415
Query: 1100 RISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQ 1279
++ +V F YPTR VK+L G++L +PG +VALVG SGCGKST + LL R Y P+ G+
Sbjct: 416 KVVFEEVHFRYPTRKKVKVLNGLNLTVKPGTSVALVGHSGCGKSTSVGLLTRLYEPEGGK 475
Query: 1280 ILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAA 1459
++ID + NI +LR+ VG+V QEP LFN +I N+ G + ED+ R K ANA
Sbjct: 476 VMIDGQDVRSLNIDWLRKTVGIVQQEPILFNDTIHNNLLIGNPSATREDMIRVCKMANAH 535
Query: 1460 DFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQ 1639
DFI+ P G T++GD VQ+SGGQKQR+AIAR L+R+PK+LLLDEATSALDA+SES+VQ
Sbjct: 536 DFIQKMPNGYETMIGDGSVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESVVQ 595
Query: 1640 SALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQV 1819
SAL NA++GRTTI+IAHRLST+R ADKI+ + G ++E G HE L+ G Y +LV AQ
Sbjct: 596 SALNNAAKGRTTIMIAHRLSTIREADKIVFFENGVIVESGNHEELVALGGRYAKLVEAQK 655
Query: 1820 FA---DVDDKPKKKEAE--------RRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXX 1966
F D++D + E E R SRQ S K + + + ++
Sbjct: 656 FKESDDIEDNGDEHEEETSTVGRHDRLSSRQVSFHKSCESLASADLEIGYASTFNTFTLK 715
Query: 1967 XX-------XXXXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAF 2125
G + + I + A+ ++Y +++G+ +
Sbjct: 716 TAQEEIENEDFAEEVQRVMEEDGVINSGYLDIFKNAQGNYLYLSVGTFFAILRGSELALL 775
Query: 2126 SLFFSQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIR 2305
+ F + F P+ + +K G + ++++ L + + +LF + AE L ++ R
Sbjct: 776 ANMFGFVFAAFKEPEDEMVKALGLIF-ILYVALGLFVFITQVISGTLFTIVAENLGLKFR 834
Query: 2306 SKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGI 2485
+ ++N+L QDA++FD P H+PG++ TRLA+DAPN+K+ +D R+ + +I S+ L
Sbjct: 835 VQSFKNLLYQDASFFDNPAHAPGKLITRLASDAPNVKAVVDTRMLQVIYSITSITINLIT 894
Query: 2486 AFYYGWQMAF---LVMAIFPFMAVGQALMMKYHGGSATSDAKEM--ENAGKTAMEAIENI 2650
+ + W++A +++ +F M + A + A + K++ + AGK A+E IE++
Sbjct: 895 GYIFCWRIAIAGTIMIVLFATMMISMAYKI------ARENLKQIRKDEAGKIAIEIIESV 948
Query: 2651 RTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLI 2830
+T+Q LT + + H + K+ I+ + + + +F + G L+
Sbjct: 949 KTIQLLTSTQRFLTHYKDAQLVQHKSEMRKSYIQSVNNAISQTFMYFAMFVCYGVGTPLM 1008
Query: 2831 FDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMT 3010
+ + ++E E R + + + ++ FPE++KA AAG++F ++ + + G
Sbjct: 1009 Y--HGIVEAEPTFRAINCMMMGSVAVMHSSHNFPEFVKAKTAAGMLFKLIYRKSK-TGDV 1065
Query: 3011 SSGTYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLL 3190
G ++ G V V F YP+RP P++ L+ GQT+ALVGPSG GKST I++L
Sbjct: 1066 MEGNNTEIRGNVLFESVKFSYPQRPMQPVMTDLHFSAHSGQTVALVGPSGTGKSTCIAML 1125
Query: 3191 ERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHE 3370
ER YD GA+ +D +++ ++ HLR +ALV QEP LF +I+EN+ +GL+ + + E
Sbjct: 1126 ERFYDVSGGALRIDGQNIKSLSLHHLRTQMALVGQEPRLFAGTIKENVCFGLK--DVSVE 1183
Query: 3371 QIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEAT 3550
++ A AN +F+ LP G +T VGEKG QLSGGQKQRIAIARAL+R+PKILLLDEAT
Sbjct: 1184 KVHQALELANASRFLANLPAGIDTEVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEAT 1243
Query: 3551 SALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAK 3730
SALD+ESE+ VQ ALD A + RTCI +AHRLS+I N+ I+ + +G V E G H L++
Sbjct: 1244 SALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDHGMVQEAGNHAHLMSL 1303
Query: 3731 RGAYFALTQKQ 3763
RG Y+ L +KQ
Sbjct: 1304 RGKYYNLIKKQ 1314
Score = 334 bits (856), Expect = 1e-89
Identities = 207/595 (34%), Positives = 308/595 (50%), Gaps = 4/595 (0%)
Frame = +2
Query: 2030 LFKILRYA-RPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIIN--VFSNPDRDQMKKDGHF 2200
L + RYA R ++ I G P + I N + N D
Sbjct: 78 LLGLFRYAERTDYALLCFGIFLSFISGIAQPGLGIIAGNITNSLLIHNATSDDFYDSAMT 137
Query: 2201 WALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRI 2380
+F + + Q F R+T +++ +++LRQ+A +FD K+ G +
Sbjct: 138 NVWLFGGIGIIVLIVNFVQYMCFQYCCIRITSKMKQHYIQSILRQNAGWFD--KNHSGTL 195
Query: 2381 TTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQAL 2560
TT+L + I I +LG + + G+ I+F+Y W++A ++M I P V +L
Sbjct: 196 TTKLHDNMERINEGIGDKLGVLIRGMVMFVAGIVISFFYEWRLALMMMGIGPLCCVCMSL 255
Query: 2561 MMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISK 2740
M + + + + AG A E++ +RTVQA Q ++ + L I K
Sbjct: 256 MSRSMSSFTSKELAGVGKAGSIAEESLMGVRTVQAFNGQEEMVEKYTVELGKGKSFAIQK 315
Query: 2741 AIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAA 2920
+ G+ G F + +G L+ K ++ P +V V+ ++ +G +
Sbjct: 316 GLWGGVFGGIFLLFLFSYFGGGIYYGGQLLRWK-IIETPGDVFIVVISMLIGAYFLGLIS 374
Query: 2921 SYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGT-YPQLSGEVKLNKVFFRYPERPAVPI 3097
+ + A AA I+ +++ P ID ++ G + G+V +V FRYP R V +
Sbjct: 375 PHLMVLLNARVAAATIYEIIDRTPDIDVYSTEGQKMTNVVGKVVFEEVHFRYPTRKKVKV 434
Query: 3098 LQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKH 3277
L GLN+ VKPG ++ALVG SGCGKST + LL RLY+P G V +D D+R +N LRK
Sbjct: 435 LNGLNLTVKPGTSVALVGHSGCGKSTSVGLLTRLYEPEGGKVMIDGQDVRSLNIDWLRKT 494
Query: 3278 IALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEK 3457
+ +V QEPILF+ +I N++ G T E + C AN H FI ++P+GYET +G+
Sbjct: 495 VGIVQQEPILFNDTIHNNLLIGNPSA--TREDMIRVCKMANAHDFIQKMPNGYETMIGDG 552
Query: 3458 GTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAH 3637
QLSGGQKQR+AIAR LIR+PK+LLLDEATSALD +SE VQ AL+ AAK RT I++AH
Sbjct: 553 SVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESVVQSALNNAAKGRTTIMIAH 612
Query: 3638 RLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSSNQSGGAFDTSE 3802
RLSTI A I+ +NG +VE G H EL+A G Y L + Q +S D +
Sbjct: 613 RLSTIREADKIVFFENGVIVESGNHEELVALGGRYAKLVEAQKFKESDDIEDNGD 667
>gi|17567267|ref|NP_510127.1| P-GlycoProtein related (pgp-13)
[Caenorhabditis elegans]
gi|7499664|pir||T21267 hypothetical protein F22E10.2 - Caenorhabditis
elegans
gi|3876292|emb|CAA91800.1| Hypothetical protein F22E10.2
[Caenorhabditis elegans]
Length = 1291
Score = 832 bits (2148), Expect = 0.0
Identities = 491/1272 (38%), Positives = 710/1272 (55%), Gaps = 31/1272 (2%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+S+ QL+R+ +T D ++L +G+I S +GV P+++II G ++ + + DP S
Sbjct: 76 VSLLQLFRFATTFDYILLLIGLITSVISGVSQPVLAIISGRMTNVLLVI-----DPLSK- 129
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAA--GFLQASCFMVICEKLSNRFRRQFFHSV 394
EF + ++N Y++LG GIF + F Q CF +C ++ R ++ S+
Sbjct: 130 --------EFKTKTMENV--YIFLGLGIFVSINDFCQYMCFQRVCSRMMTVMRNRYISSI 179
Query: 395 MRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLT 574
+RQ W+DKN SGT++ +L DN+ER+++G GDK+G+ + ++ I ++ Y+W L
Sbjct: 180 LRQNAGWFDKNLSGTITTRLNDNMERIQDGVGDKLGVLIRGISMVIASVVISLIYEWRLA 239
Query: 575 LIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECK 754
L+M+ L P IC + AG IAEE L +RT+ AFNGQE
Sbjct: 240 LMMLGLIPVSTICMTLLSRFLEKSTGEELEKVGEAGAIAEECLMGVRTIQAFNGQEEMVA 299
Query: 755 RYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVF 934
+YE L GKK I F G FF I+ + +AF +G +Y G L
Sbjct: 300 KYEKQLNSGKKHAIWGGFWSG-----FFGGIFFFWLMAF-MGCGILYGGYL--------- 344
Query: 935 FSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVN 1114
+G AAS+Y+ IDR+P+ID YS G+ K+ G+++
Sbjct: 345 -----------------LKVGIIKSPAASIYKTIDRVPKIDPYSRHGKKIEKVVGKVTFE 387
Query: 1115 KVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDD 1294
V F YPTR + K+L G++L +PG +VALVG SGCGKST + LL R Y P+ G + ID
Sbjct: 388 NVHFRYPTRKEAKVLNGLNLTVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEQGSVQIDG 447
Query: 1295 IPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKT 1474
+ + D N+++LR +VG+V QEP LFN +I N+ +G D + E + R K ANA DFIK
Sbjct: 448 VDVRDLNLEWLRNVVGIVQQEPILFNDTIHNNLLFGNPDATRETMIRVCKMANAHDFIKK 507
Query: 1475 FPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALEN 1654
P+G +T +GD GVQ+SGGQKQR+AIAR L+R+PK+LLLDEATSALDA+SES+VQSAL N
Sbjct: 508 MPKGYDTQIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESVVQSALNN 567
Query: 1655 ASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVF-ADV 1831
AS+GRTTI+IAHRLST+R ADKI+ + G ++E G HE L+ G Y +LV AQ F D
Sbjct: 568 ASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVNLGGRYFDLVKAQAFKQDP 627
Query: 1832 DDKPKKKEAE-------------RRMS---RQTSQRKGSVNFK----TQESQVDXXXXXX 1951
D+ +KE E R++S ++S R GS F+ S
Sbjct: 628 DEIALEKEEEDQFDEFDKPTVFNRKVSVRNSRSSGRSGSEEFRRGSLANHSFDRFRKASH 687
Query: 1952 XXXXXXXXXXXXXXXXXXXXGAVKANLFKILRYAR-PEWIYXXXXXXXXLIQGAVMPAFS 2128
G + A I + A+ + Y LI+G +P F+
Sbjct: 688 IPSAEDEAFALRVKETMEKDGEITAGFLDIFKNAQGRNYTYMLIGLSAALIRGLDLPTFA 747
Query: 2129 LFFSQIINVFS-NPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQ---CSLFGVAAERLTM 2296
L F+ + F P +M H A+ + A FQ +F + +E L +
Sbjct: 748 LLFAWVFEGFEFVPYGGKMM---HRLAMSVIAHCAAGLGIWFFQTLSTVMFAIVSENLGV 804
Query: 2297 RIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGG 2476
R R +RN+L QDA YFD P H+PG + TRLA D P +K+ +D R+ + A A+V
Sbjct: 805 RFRVAAFRNLLYQDAAYFDNPAHAPGSLITRLAADPPCVKAVVDGRMMQVVYATAAVIAC 864
Query: 2477 LGIAFYYGWQMAFL---VMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIEN 2647
+ I F WQ+A L ++ + F+ G A + ++ E ++AGK A+E IEN
Sbjct: 865 VTIGFINCWQVAILGTALIFLLGFIMAGLAFKISI----VAAEHMENDDAGKIAIEIIEN 920
Query: 2648 IRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFL 2827
++T+Q LT + N + + + K++ + Y + + F Y + F F L +
Sbjct: 921 VKTIQLLTRTRRFLNSYENESKKRKRTELRKSVYEAVNYCISQN--FMYYMSCFCFALAI 978
Query: 2828 IFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGM 3007
+ R L A+ I +A +FP+++ A AAG +FN++ +P+ G
Sbjct: 979 RIINQGDQTVDKTFRCLMAMMLCCEGIIMSAQFFPQFVGAKSAAGQMFNLINRQPQ-TGD 1037
Query: 3008 TSSGTYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISL 3187
SGT P++ G + V F YP+RP P+++ L GQT+ALVGPSG GKST I +
Sbjct: 1038 LKSGTKPEIRGNILFENVKFSYPQRPHQPVMKQLQWTALRGQTVALVGPSGSGKSTCIGM 1097
Query: 3188 LERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTH 3367
LER YD GA+ +D D++ ++ HLR +ALV QEP LF +IREN+ GL+ +
Sbjct: 1098 LERFYDVTGGALRMDGQDIKNISLYHLRTQMALVGQEPRLFVGTIRENVCLGLK--DVPL 1155
Query: 3368 EQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEA 3547
E+I A AN ++F+ LPDG +T VGE+G QLSGGQKQRIAIARAL+R+PKILLLDEA
Sbjct: 1156 EKINQALELANANRFLGNLPDGIDTEVGERGGQLSGGQKQRIAIARALVRDPKILLLDEA 1215
Query: 3548 TSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIA 3727
TSALD+ESE+ VQ ALD A + RTCI +AHRLS+I N+ I+ + +G+V E GTH EL+
Sbjct: 1216 TSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDDGRVQESGTHKELMQ 1275
Query: 3728 KRGAYFALTQKQ 3763
+G YF L +KQ
Sbjct: 1276 LKGKYFELIKKQ 1287
Score = 308 bits (790), Expect = 5e-82
Identities = 199/587 (33%), Positives = 309/587 (51%), Gaps = 4/587 (0%)
Frame = +2
Query: 2027 NLFKILRYARP-EWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFS--NPDRDQMKKDGH 2197
+L ++ R+A ++I +I G P ++ ++ NV +P + K
Sbjct: 77 SLLQLFRFATTFDYILLLIGLITSVISGVSQPVLAIISGRMTNVLLVIDPLSKEFKTKTM 136
Query: 2198 FWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGR 2377
+FL L + Q F R+ +R++ ++LRQ+A +FD K+ G
Sbjct: 137 ENVYIFLGLGIFVSINDFCQYMCFQRVCSRMMTVMRNRYISSILRQNAGWFD--KNLSGT 194
Query: 2378 ITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQA 2557
ITTRL + I+ + +LG + I+ V + I+ Y W++A +++ + P +
Sbjct: 195 ITTRLNDNMERIQDGVGDKLGVLIRGISMVIASVVISLIYEWRLALMMLGLIPVSTICMT 254
Query: 2558 LMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNIS 2737
L+ ++ S + +++ AG A E + +RT+QA Q ++ + L++
Sbjct: 255 LLSRFLEKSTGEELEKVGEAGAIAEECLMGVRTIQAFNGQEEMVAKYEKQLNSGK----K 310
Query: 2738 KAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFA 2917
AI G GF I FF + AF G +++ +L +G
Sbjct: 311 HAIWGGFWSGFFGGI-FFFWLMAF-MGCGILYGGYLLK------------------VGII 350
Query: 2918 ASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGT-YPQLSGEVKLNKVFFRYPERPAVP 3094
S A I+ ++ P+ID + G ++ G+V V FRYP R
Sbjct: 351 KS----------PAASIYKTIDRVPKIDPYSRHGKKIEKVVGKVTFENVHFRYPTRKEAK 400
Query: 3095 ILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRK 3274
+L GLN+ V+PG ++ALVG SGCGKST + LL RLY+P +G+V +D D+R +N + LR
Sbjct: 401 VLNGLNLTVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEQGSVQIDGVDVRDLNLEWLRN 460
Query: 3275 HIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGE 3454
+ +V QEPILF+ +I N+++G + T E + C AN H FI ++P GY+T++G+
Sbjct: 461 VVGIVQQEPILFNDTIHNNLLFGNP--DATRETMIRVCKMANAHDFIKKMPKGYDTQIGD 518
Query: 3455 KGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVA 3634
G QLSGGQKQR+AIAR LIR+PK+LLLDEATSALD +SE VQ AL+ A+K RT I++A
Sbjct: 519 GGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESVVQSALNNASKGRTTIMIA 578
Query: 3635 HRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSSNQ 3775
HRLSTI A I+ + G +VE G H EL+ G YF L + Q+ Q
Sbjct: 579 HRLSTIREADKIVFFEKGVIVEAGNHEELVNLGGRYFDLVKAQAFKQ 625
Score = 280 bits (716), Expect = 2e-73
Identities = 184/580 (31%), Positives = 291/580 (49%), Gaps = 2/580 (0%)
Frame = +2
Query: 92 LAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHEVIQN 271
+ +G+ + G+ LP +++ V + F E + H + +
Sbjct: 729 MLIGLSAALIRGLDLPTFALLFAWVFEGF---------------EFVPYGGKMMHRLAMS 773
Query: 272 CLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYDK--NTSGTLS 445
+ + G GI+ L F ++ E L RFR F +++ Q+ A++D + G+L
Sbjct: 774 VIAHCAAGLGIWFFQTLSTVMFAIVSENLGVRFRVAAFRNLLYQDAAYFDNPAHAPGSLI 833
Query: 446 NKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFX 625
+L + V+ ++ A I + F W + ++ +L F++ +
Sbjct: 834 TRLAADPPCVKAVVDGRMMQVVYATAAVIACVTIGFINCWQVAILGTALI-FLLGFIMAG 892
Query: 626 XXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKS 805
+ AG IA E++ +++T+ YE+ + K+T ++KS
Sbjct: 893 LAFKISIVAAEHMENDDAGKIAIEIIENVKTIQLLTRTRRFLNSYENESKKRKRTELRKS 952
Query: 806 FLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQF 985
+Y C F + + G ++M+ + + Q F
Sbjct: 953 VYEAVNYCISQNFMYYMSCFCFALAIRIINQGDQTVDKTFRCLMAMMLCCEGIIMSAQFF 1012
Query: 986 ATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKG 1165
A AA ++ +I+R P+ + T +I G I V+F+YP R ++K
Sbjct: 1013 PQFVGAKSAAGQMFNLINRQPQTG--DLKSGTKPEIRGNILFENVKFSYPQRPHQPVMKQ 1070
Query: 1166 VSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGV 1345
+ A GQTVALVG SG GKST I +L+RFY+ G + +D I++ ++ +LR + +
Sbjct: 1071 LQWTALRGQTVALVGPSGSGKSTCIGMLERFYDVTGGALRMDGQDIKNISLYHLRTQMAL 1130
Query: 1346 VSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQMS 1525
V QEP LF +I +N+ G DV E I +AL+ ANA F+ P+G++T VG+RG Q+S
Sbjct: 1131 VGQEPRLFVGTIRENVCLGLKDVPLEKINQALELANANRFLGNLPDGIDTEVGERGGQLS 1190
Query: 1526 GGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLSTV 1705
GGQKQRIAIARALVR+PKILLLDEATSALD+ESE VQ AL+ A GRT I IAHRLS++
Sbjct: 1191 GGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSI 1250
Query: 1706 RNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFA 1825
+N+D I+ + G+V E GTH+ L++ KG Y EL+ Q A
Sbjct: 1251 QNSDLIVYIDDGRVQESGTHKELMQLKGKYFELIKKQDLA 1290
>gi|14715462|dbj|BAB62040.1| CjMDR1 [Coptis japonica]
Length = 1289
Score = 829 bits (2142), Expect = 0.0
Identities = 472/1254 (37%), Positives = 705/1254 (55%), Gaps = 11/1254 (0%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+ ++L + + D L++ +G I + A G +P+M++++G++ F + N+T
Sbjct: 54 VPYYKLLSFADSKDVLLMVIGTIAAVANGASMPVMTLLLGDLINAFGQ------NANNTD 107
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
+ + ++ LK+VYL G A F Q +C+MV E+ + R R + +++R
Sbjct: 108 TLRVVSKV---------ALKFVYLSIGAGVASFFQVACWMVTGERQAARIRSLYLKTILR 158
Query: 401 QEIAWYDKNTS-GTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
Q++A++DK T+ G + ++ + +++ G+KVG Q+ + FIGGF +AF WLLTL
Sbjct: 159 QDVAFFDKETNTGEVVGRMSGDTVLIQDAIGEKVGKFIQLFSTFIGGFLIAFVKGWLLTL 218
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
+M++ P ++ CG Y+ AG + E+ + SIRTV +F G+++ +
Sbjct: 219 VMLTSIPPLVFCGALMTITISKMASRGQVAYSQAGIVVEQTIGSIRTVASFTGEKHAVTQ 278
Query: 758 YEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFF 937
YE L GI + G GL S ++I+ SY LA W G + G V+ +
Sbjct: 279 YEKYLNKAYLAGIHEGLASGVGLGSVLLVIFCSYSLAVWFGGKMIIEKGYNGGNVINIIV 338
Query: 938 SVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNK 1117
+V+ GSM+LGQA AA + E I R PEID+Y T G I G I +
Sbjct: 339 AVLTGSMSLGQASPCLGAFAAGQAAAYKMLETIKRKPEIDSYDTSGHKSDDIRGDIELRD 398
Query: 1118 VEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDI 1297
V FTYP R D +I G SL G T ALVG SG GKST+I L++RFY+P AG++LID +
Sbjct: 399 VSFTYPARPDEQIFNGFSLFIPSGTTSALVGQSGSGKSTVISLIERFYDPQAGEVLIDGV 458
Query: 1298 PIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTF 1477
++DF ++++R +G+VSQEP LF +SI NI YG+ + E+I A + ANA+ FI
Sbjct: 459 NLKDFQLRWIRGKIGLVSQEPVLFASSIRDNIAYGKDGATVEEIKAATERANASKFIDKL 518
Query: 1478 PEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENA 1657
P+GL+TLVG+ G Q+SGGQKQRIAIARA++++P+ILLLDEATSALDAESE IVQ AL+
Sbjct: 519 PQGLDTLVGEHGTQLSGGQKQRIAIARAILKDPRILLLDEATSALDAESEHIVQEALDRI 578
Query: 1658 SRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTH-ETLIEQKGLYHELVHAQVFADVD 1834
RTT+++AHRLSTVRNAD I V+ G+++E G+H + L+ G Y +L+ Q +
Sbjct: 579 MVNRTTVIVAHRLSTVRNADTIAVIHRGKIVEKGSHLDLLLNPDGAYCQLIRLQEIGRSE 638
Query: 1835 -DKPKKKEAERRMSRQTS-----QRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXX 1996
DK + E+ S+Q S R S +
Sbjct: 639 VDKAENVESGLNSSQQHSIGRSISRGSSGVGNSSRHSFSVSFGLPTGHIYETTAGLESTS 698
Query: 1997 XXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRD 2176
+ L ++ +PE ++ G + P F + S +I F P+ D
Sbjct: 699 PAPIGQTQEVPLRRLATLNKPEIPVLLLGVISAMVNGVIFPIFGVLLSSVIKTFYEPE-D 757
Query: 2177 QMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDM 2356
+++KD FWA MF++L + F VA RL RIRS +R V + +FD
Sbjct: 758 KLRKDTRFWAFMFIILGVASFVAAPATAYFFAVAGCRLIQRIRSMCFRTVAHMEIDWFDE 817
Query: 2357 PKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFP 2536
P+H+ G I +L+ DA ++ + L + A+ GL IAF W +A +++ + P
Sbjct: 818 PEHASGAIGAKLSADASTVRGLVGDALALLVQNAATAVCGLVIAFVANWTLALIILVLIP 877
Query: 2537 FMAVGQALMMKYHGGSATSDAKEM-ENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLD 2713
+ V + MK+ G ++DAK M E A + A +A+ +IRTV + + K+ ++ +
Sbjct: 878 LIGVNGYVQMKFMKG-FSADAKMMYEEASQVANDAVGSIRTVASFCAEEKVMQLYKKKCE 936
Query: 2714 APHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISF 2893
P I + +I G+ +G + + F YA +F G L+ +V RV FA++
Sbjct: 937 GPMKTGIRQGLISGIGFGISFFLLFNVYATSFYAGARLVDAGKTTF--SDVFRVFFALTM 994
Query: 2894 SFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSG-TYPQLSGEVKLNKVFFR 3070
+ I ++S P+ KA + IF +L+ + +ID SG T + GE++L + F+
Sbjct: 995 AALGISQSSSLAPDSSKAKSSTASIFGILDRKSKIDSSDESGMTVENVKGEIELRHISFK 1054
Query: 3071 YPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQ 3250
YP RP + I + L++ + G+T+ALVG SG GKSTVISLL+R YDP G +T+D ++++
Sbjct: 1055 YPTRPDIQIFRDLSLAIHSGKTVALVGESGSGKSTVISLLQRFYDPDSGHITLDGIEIQK 1114
Query: 3251 MNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPD 3430
+ LR + LVSQEP+LF+ +IR NI YG + G+ T +I A AN HKFI L
Sbjct: 1115 FQLRWLRLQMGLVSQEPVLFNETIRANIAYG-KEGDATETEILAAAELANAHKFISGLQQ 1173
Query: 3431 GYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAK 3610
GY+T VGE+G QLSGGQKQR+AIARA+++ PKILLLDEATSALD ESE+ VQ ALD
Sbjct: 1174 GYDTVVGERGIQLSGGQKQRVAIARAMVKAPKILLLDEATSALDAESERVVQDALDKVMV 1233
Query: 3611 DRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELI-AKRGAYFALTQKQSS 3769
+RT + VAHRLSTI NA I VVKNG + E+G HN+LI K G Y +L +S
Sbjct: 1234 NRTTVWVAHRLSTIKNADVIAVVKNGVIAEKGKHNDLINVKDGVYASLVALHTS 1287
Score = 337 bits (865), Expect = 1e-90
Identities = 214/586 (36%), Positives = 316/586 (53%), Gaps = 4/586 (0%)
Frame = +2
Query: 2033 FKILRYA-RPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFS-NPDRDQMKKDGHFWA 2206
+K+L +A + + + GA MP +L +IN F N + + A
Sbjct: 57 YKLLSFADSKDVLLMVIGTIAAVANGASMPVMTLLLGDLINAFGQNANNTDTLRVVSKVA 116
Query: 2207 LMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITT 2386
L F+ L+ G + FQ + + V ER RIRS + +LRQD +FD ++ G +
Sbjct: 117 LKFVYLSIGAGVASFFQVACWMVTGERQAARIRSLYLKTILRQDVAFFDKETNT-GEVVG 175
Query: 2387 RLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMM 2566
R++ D I+ AI ++G ++ GG IAF GW + +++ P + ALM
Sbjct: 176 RMSGDTVLIQDAIGEKVGKFIQLFSTFIGGFLIAFVKGWLLTLVMLTSIPPLVFCGALMT 235
Query: 2567 KYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAI 2746
A+ AG + I +IRTV + T + + +L+ + I + +
Sbjct: 236 ITISKMASRGQVAYSQAGIVVEQTIGSIRTVASFTGEKHAVTQYEKYLNKAYLAGIHEGL 295
Query: 2747 IRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASY 2926
G+ G + F +Y+ A FG +I +K NV+ ++ A+ ++G A+
Sbjct: 296 ASGVGLGSVLLVIFCSYSLAVWFGGKMIIEKGY--NGGNVINIIVAVLTGSMSLGQASPC 353
Query: 2927 FPEYIKATFAAGLIFNMLEEEPRIDGMTSSG-TYPQLSGEVKLNKVFFRYPERPAVPILQ 3103
+ AA + ++ +P ID +SG + G+++L V F YP RP I
Sbjct: 354 LGAFAAGQAAAYKMLETIKRKPEIDSYDTSGHKSDDIRGDIELRDVSFTYPARPDEQIFN 413
Query: 3104 GLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIA 3283
G ++ + G T ALVG SG GKSTVISL+ER YDP G V +D +L+ + +R I
Sbjct: 414 GFSLFIPSGTTSALVGQSGSGKSTVISLIERFYDPQAGEVLIDGVNLKDFQLRWIRGKIG 473
Query: 3284 LVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGT 3463
LVSQEP+LF +SIR+NI YG T E+I+ A +AN KFID+LP G +T VGE GT
Sbjct: 474 LVSQEPVLFASSIRDNIAYGKDGA--TVEEIKAATERANASKFIDKLPQGLDTLVGEHGT 531
Query: 3464 QLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRL 3643
QLSGGQKQRIAIARA++++P+ILLLDEATSALD ESE VQ ALD +RT ++VAHRL
Sbjct: 532 QLSGGQKQRIAIARAILKDPRILLLDEATSALDAESEHIVQEALDRIMVNRTTVIVAHRL 591
Query: 3644 STIVNAGCIMVVKNGQVVEQGTHNELIAK-RGAYFALTQKQSSNQS 3778
ST+ NA I V+ G++VE+G+H +L+ GAY L + Q +S
Sbjct: 592 STVRNADTIAVIHRGKIVEKGSHLDLLLNPDGAYCQLIRLQEIGRS 637
>gi|39587987|emb|CAE57218.1| Hypothetical protein CBG00078
[Caenorhabditis briggsae]
Length = 1282
Score = 827 bits (2136), Expect = 0.0
Identities = 471/1189 (39%), Positives = 665/1189 (55%), Gaps = 26/1189 (2%)
Frame = +2
Query: 275 LKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYDKNTSGTLSNKL 454
L ++ + C I + CF C ++ + R ++ +SV+RQ W+DKN SGT++ KL
Sbjct: 98 LLFIGIICAIISGISQPYMCFQHCCSRIMAQMRHRYVYSVLRQNAGWFDKNHSGTIATKL 157
Query: 455 FDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXXXX 634
D++ER+REG GDK+G+ + +A + VA+ Y+W L +M+ ++P + C
Sbjct: 158 NDSMERIREGIGDKLGVLIRGVAMLLASIVVAYIYEWRLACMMLGVAPTCVGCMSLMARQ 217
Query: 635 XXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFLI 814
AG IAEE L +RTV AFNGQE +RY L G+K I K F
Sbjct: 218 MTATTVKELGGVEKAGSIAEESLMGVRTVQAFNGQEEMVERYRVELNKGRKFAIWKGFWS 277
Query: 815 GAGLASFFVIIYASYCLAFWVGTNFVYSGRLES-GTVLTVFFSVMMGSMALGQAGQQFAT 991
G FF ++A F G + G + S G V + ++++GS LG
Sbjct: 278 GLYGGLFFFWLFAFQGCGFLYGAYLLKIGIITSPGDVFIIVMAMLLGSYFLGLISPHLMV 337
Query: 992 IGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKGVS 1171
+ A AAAS+YE I+R+P+ID YS +G+ K+ GR+ V F YPTR D KIL G++
Sbjct: 338 LLNARVAAASIYETIERVPKIDPYSKKGRFLDKVIGRVKFENVHFRYPTRKDAKILNGLN 397
Query: 1172 LDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVS 1351
L +PG +VALVG SGCGKST + LL R Y P+ G + ID + + NI YLR +VG+V
Sbjct: 398 LTIEPGTSVALVGHSGCGKSTSVGLLTRLYEPETGNVTIDGTDVRELNIDYLRNVVGIVQ 457
Query: 1352 QEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQMSGG 1531
QEP LFN +I N+ G + E + K ANA DFI+ P+G +TL+GD GVQ+SGG
Sbjct: 458 QEPILFNDTIHNNLLLGNPNAKREKMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGG 517
Query: 1532 QKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLSTVRN 1711
QKQR+AIAR L+R+PK+LLLDEATSALDA+SES+VQSAL NAS+GRTTI+IAHRLST+R
Sbjct: 518 QKQRVAIARTLIRDPKVLLLDEATSALDAQSESVVQSALNNASKGRTTIMIAHRLSTIRE 577
Query: 1712 ADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFA--------------DVDDKPKK 1849
AD I+ + G ++E G H L+ +G Y++LV AQ F D+D P
Sbjct: 578 ADMIVFFEKGVIVEAGNHAELVRLEGRYYDLVKAQAFKPDDNPISQYDEIAEDIDLGPSA 637
Query: 1850 KEAERRMSRQTSQRKGSVN----FKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXX-- 2011
R S TS + ++ F+ D
Sbjct: 638 TAIHSRQSSFTSSIRSRISGAEAFRRGTLGADSFAGGRSSARADAENAAFAEEVAKVMEQ 697
Query: 2012 -GAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKK 2188
G + A I + A + LI+G + AF+L F + F D K
Sbjct: 698 DGQISAGFLDIFKNAHGNYTVMLLGFVTGLIRGLELTAFALLFGWVFEGFQYLTVDNGKM 757
Query: 2189 DGHFWALMFLVLAAVQG----TSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDM 2356
M ++ G S F + +E L +R R +RN+L QDA++FD
Sbjct: 758 MHRM--AMAVIAYGCSGFGCFVSQFLSSVFFAIVSENLALRFRVMSFRNLLYQDASFFDN 815
Query: 2357 PKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFP 2536
P H+PG++ TRLATDAPN K+ +D R+ + A++++ + IAF Y W +A L A+
Sbjct: 816 PAHAPGKLITRLATDAPNCKTVVDSRMLQVLYALSAIIANIAIAFIYCWYLAILGTALII 875
Query: 2537 FMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDA 2716
+AV + Y + + AG+ A+E IEN++T+Q LT + + +
Sbjct: 876 LLAVTMC-GLAYKISLLNMKQIQDDEAGRIAIEIIENVKTIQLLTRCDHFFERYQKSSKS 934
Query: 2717 PHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFS 2896
+ K +I + Y S ++ F G+ LI+ N ++V + A+ +
Sbjct: 935 QKRSELKKGLIEAVNYTITQSFMYYMMCFCFALGIRLIYQGN--KSSQDVFQGNIAMLLT 992
Query: 2897 FGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVFFRYP 3076
+ +A YFPE++KA A+GL+FN++ +PR G GT P++ G + V F YP
Sbjct: 993 AMGVMNSAQYFPEFVKAKTASGLLFNIIYRKPRT-GDLMEGTCPEVRGNILFEDVKFSYP 1051
Query: 3077 ERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMN 3256
+RP PI++GL GQT+ALVGPSG GKST I +LER YD G + +D D+R ++
Sbjct: 1052 QRPHQPIMKGLQWTALRGQTVALVGPSGSGKSTCIGMLERFYDVTGGVLRIDGQDIRGLS 1111
Query: 3257 PKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGY 3436
HLR +ALV QEP LF +I+ENI GL+ + E+I A AN ++F+ LP G
Sbjct: 1112 LFHLRTQMALVGQEPRLFAGTIKENICLGLE--NVSMEKINHALELANANRFLSNLPAGI 1169
Query: 3437 ETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDR 3616
ET VGEKG++LSGGQKQRIAIARAL+R+PKILLLDEATSALD+ESEK VQ ALD A + R
Sbjct: 1170 ETDVGEKGSKLSGGQKQRIAIARALVRDPKILLLDEATSALDSESEKAVQEALDRAREGR 1229
Query: 3617 TCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQ 3763
TCI +AHRLS+I N+ I+ ++NG+V E G H +L+AK+G Y+ L QKQ
Sbjct: 1230 TCITIAHRLSSIQNSDVIVYIENGRVQEAGNHKQLMAKKGKYYELIQKQ 1278
Score = 336 bits (861), Expect = 3e-90
Identities = 194/525 (36%), Positives = 294/525 (55%), Gaps = 1/525 (0%)
Frame = +2
Query: 2195 HFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPG 2374
HF + ++ A + G S + C F R+ ++R + +VLRQ+A +FD K+ G
Sbjct: 96 HFLLFIGIICAIISGISQPYMC--FQHCCSRIMAQMRHRYVYSVLRQNAGWFD--KNHSG 151
Query: 2375 RITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQ 2554
I T+L I+ I +LG + +A + + +A+ Y W++A +++ + P
Sbjct: 152 TIATKLNDSMERIREGIGDKLGVLIRGVAMLLASIVVAYIYEWRLACMMLGVAPTCVGCM 211
Query: 2555 ALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNI 2734
+LM + + + +E AG A E++ +RTVQA Q ++ + L+ I
Sbjct: 212 SLMARQMTATTVKELGGVEKAGSIAEESLMGVRTVQAFNGQEEMVERYRVELNKGRKFAI 271
Query: 2735 SKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGF 2914
K GL G F F +G +L+ ++ P +V ++ A+ +G
Sbjct: 272 WKGFWSGLYGGLFFFWLFAFQGCGFLYGAYLL-KIGIITSPGDVFIIVMAMLLGSYFLGL 330
Query: 2915 AASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTY-PQLSGEVKLNKVFFRYPERPAV 3091
+ + + A AA I+ +E P+ID + G + ++ G VK V FRYP R
Sbjct: 331 ISPHLMVLLNARVAAASIYETIERVPKIDPYSKKGRFLDKVIGRVKFENVHFRYPTRKDA 390
Query: 3092 PILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLR 3271
IL GLN+ ++PG ++ALVG SGCGKST + LL RLY+P G VT+D D+R++N +LR
Sbjct: 391 KILNGLNLTIEPGTSVALVGHSGCGKSTSVGLLTRLYEPETGNVTIDGTDVRELNIDYLR 450
Query: 3272 KHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVG 3451
+ +V QEPILF+ +I N++ G P + IE C AN H FI+++P GY+T +G
Sbjct: 451 NVVGIVQQEPILFNDTIHNNLLLG-NPNAKREKMIEV-CKMANAHDFIEKMPKGYDTLIG 508
Query: 3452 EKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVV 3631
+ G QLSGGQKQR+AIAR LIR+PK+LLLDEATSALD +SE VQ AL+ A+K RT I++
Sbjct: 509 DGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESVVQSALNNASKGRTTIMI 568
Query: 3632 AHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQS 3766
AHRLSTI A I+ + G +VE G H EL+ G Y+ L + Q+
Sbjct: 569 AHRLSTIREADMIVFFEKGVIVEAGNHAELVRLEGRYYDLVKAQA 613
Score = 309 bits (792), Expect = 3e-82
Identities = 194/580 (33%), Positives = 303/580 (51%), Gaps = 4/580 (0%)
Frame = +2
Query: 89 MLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHEVIQ 268
++ +G + G+ L +++ G V + F L + H +
Sbjct: 718 VMLLGFVTGLIRGLELTAFALLFGWVFEGFQYL--------------TVDNGKMMHRMAM 763
Query: 269 NCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYDK--NTSGTL 442
+ Y G G F + FL + F ++ E L+ RFR F +++ Q+ +++D + G L
Sbjct: 764 AVIAYGCSGFGCFVSQFLSSVFFAIVSENLALRFRVMSFRNLLYQDASFFDNPAHAPGKL 823
Query: 443 SNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMI--CG 616
+L + + ++ ++ I A+AF Y W L ++ +L + + CG
Sbjct: 824 ITRLATDAPNCKTVVDSRMLQVLYALSAIIANIAIAFIYCWYLAILGTALIILLAVTMCG 883
Query: 617 LFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGI 796
L Q AG IA E++ +++T+ ++ +RY+ + + K++ +
Sbjct: 884 L---AYKISLLNMKQIQDDEAGRIAIEIIENVKTIQLLTRCDHFFERYQKSSKSQKRSEL 940
Query: 797 KKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAG 976
KK + +Y C F +G +Y G S V ++++ +M + +
Sbjct: 941 KKGLIEAVNYTITQSFMYYMMCFCFALGIRLIYQGNKSSQDVFQGNIAMLLTAMGVMNSA 1000
Query: 977 QQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKI 1156
Q F A A+ L+ +I R P EG P ++ G I V+F+YP R I
Sbjct: 1001 QYFPEFVKAKTASGLLFNIIYRKPRTGDLM-EGTCP-EVRGNILFEDVKFSYPQRPHQPI 1058
Query: 1157 LKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQL 1336
+KG+ A GQTVALVG SG GKST I +L+RFY+ G + ID I ++ +LR
Sbjct: 1059 MKGLQWTALRGQTVALVGPSGSGKSTCIGMLERFYDVTGGVLRIDGQDIRGLSLFHLRTQ 1118
Query: 1337 VGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEGLNTLVGDRGV 1516
+ +V QEP LF +I++NI G +VS E I AL+ ANA F+ P G+ T VG++G
Sbjct: 1119 MALVGQEPRLFAGTIKENICLGLENVSMEKINHALELANANRFLSNLPAGIETDVGEKGS 1178
Query: 1517 QMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRL 1696
++SGGQKQRIAIARALVR+PKILLLDEATSALD+ESE VQ AL+ A GRT I IAHRL
Sbjct: 1179 KLSGGQKQRIAIARALVRDPKILLLDEATSALDSESEKAVQEALDRAREGRTCITIAHRL 1238
Query: 1697 STVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQ 1816
S+++N+D I+ ++ G+V E G H+ L+ +KG Y+EL+ Q
Sbjct: 1239 SSIQNSDVIVYIENGRVQEAGNHKQLMAKKGKYYELIQKQ 1278
>gi|15217785|ref|NP_171753.1| multidrug resistance P-glycoprotein,
putative [Arabidopsis thaliana]
gi|25297455|pir||E86155 probable ABC transporter [imported] -
Arabidopsis thaliana
gi|9972378|gb|AAG10628.1| Putative ABC transporter [Arabidopsis
thaliana]
Length = 1278
Score = 824 bits (2128), Expect = 0.0
Identities = 462/1248 (37%), Positives = 698/1248 (55%), Gaps = 12/1248 (0%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+ ++L+ + + D L++ G I + G+ LP M+++ G++ +F
Sbjct: 41 VPFYKLFAFADSSDVLLMICGSIGAIGNGMSLPFMTLLFGDLIDSF-------------- 86
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
K + V + CLK+VYLG G A FLQ +C+M+ E+ + R R + +++R
Sbjct: 87 -GKNQNNKDIVDVVSKVCLKFVYLGLGTLGAAFLQVACWMITGERQAARIRSTYLKTILR 145
Query: 401 QEIAWYDKNTS-GTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
Q+I ++D T+ G + ++ + +++ G+KVG Q+++ F+GGF +AF WLLTL
Sbjct: 146 QDIGFFDVETNTGEVVGRMSGDTVLIQDAMGEKVGKFIQLVSTFVGGFVLAFIKGWLLTL 205
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
+M++ P + + G YA A + E+ + SIRTV +F G++
Sbjct: 206 VMLTSIPLLAMAGAAMALIVTRASSRGQAAYAKAATVVEQTIGSIRTVASFTGEKQAINS 265
Query: 758 YEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFF 937
Y+ + K+ I++ F G GL F + ++SY LA W G + G V+ V
Sbjct: 266 YKKFITSAYKSSIQQGFSTGLGLGVMFFVFFSSYALAIWFGGKMILEKGYTGGAVINVII 325
Query: 938 SVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNK 1117
V+ GSM+LGQ AA ++E I R P IDAY G+ I G I +
Sbjct: 326 IVVAGSMSLGQTSPCVTAFAAGQAAAYKMFETIKRKPLIDAYDVNGKVLEDIRGDIELKD 385
Query: 1118 VEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDI 1297
V F+YP R D +I G SL G T ALVG SG GKST+I L++RFY+P +G +LID +
Sbjct: 386 VHFSYPARPDEEIFDGFSLFIPSGATAALVGESGSGKSTVISLIERFYDPKSGAVLIDGV 445
Query: 1298 PIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTF 1477
+++F +K++R +G+VSQEP LF++SI +NI YG+ + + E+I A + ANAA FI
Sbjct: 446 NLKEFQLKWIRSKIGLVSQEPVLFSSSIMENIAYGKENATVEEIKAATELANAAKFIDKL 505
Query: 1478 PEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENA 1657
P+GL+T+VG+ G Q+SGGQKQRIAIARA++++P+ILLLDEATSALDAESE +VQ AL+
Sbjct: 506 PQGLDTMVGEHGTQLSGGQKQRIAIARAILKDPRILLLDEATSALDAESERVVQEALDRV 565
Query: 1658 SRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLI-EQKGLYHELVHAQVFADVD 1834
RTT+++AHRLSTVRNAD I V+ G+++E G+H L+ + +G Y +L+ Q +++
Sbjct: 566 MVNRTTVIVAHRLSTVRNADMIAVIHRGKMVEKGSHSELLKDSEGAYSQLIRLQ---EIN 622
Query: 1835 DKPKKKEAERRMSRQTSQRKGSV--------NFKTQESQVDXXXXXXXXXXXXXXXXXXX 1990
K E S + S K S+ + + V
Sbjct: 623 KDVKTSELSSGSSFRNSNLKKSMEGTSSVGNSSRHHSLNVLGLTTGLDLGSHSQRAGQDE 682
Query: 1991 XXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPD 2170
K +L +I +PE I GA+ P F + S++I F P
Sbjct: 683 TGTASQEPLPKVSLTRIAALNKPEIPVLLLGTVAAAINGAIFPLFGILISRVIEAFFKPA 742
Query: 2171 RDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYF 2350
+ +K+D FWA++F+ L Q LF VA +L RIRS + + + +F
Sbjct: 743 HE-LKRDSRFWAIIFVALGVTSLIVSPTQMYLFAVAGGKLIRRIRSMCFEKAVHMEVAWF 801
Query: 2351 DMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAI 2530
D P++S G + RL+ DA I++ + L +AS GL IAF W++A +++ +
Sbjct: 802 DEPQNSSGTMGARLSADATLIRALVGDALSLAVQNVASAASGLIIAFTASWELALIILVM 861
Query: 2531 FPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHL 2710
P + + + +K+ G + + E A + A +A+ +IRTV + + K+ ++
Sbjct: 862 LPLIGINGFVQVKFMKGFSADAKSKYEEASQVANDAVGSIRTVASFCAEEKVMQMYKKQC 921
Query: 2711 DAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAIS 2890
+ P I + I GL +GF+ I F YA +F G L+ D NV +V FA++
Sbjct: 922 EGPIKDGIKQGFISGLGFGFSFFILFCVYATSFYAGARLVEDGKTTFN--NVFQVFFALT 979
Query: 2891 FSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKLNKVFF 3067
+ I ++++ P+ KA AA IF +++ + +ID +GT + + G+++L + F
Sbjct: 980 MAAIGISQSSTFAPDSSKAKVAAASIFAIIDRKSKIDSSDETGTVLENVKGDIELRHLSF 1039
Query: 3068 RYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLR 3247
YP RP + I + L + ++ G+T+ALVG SG GKSTVISLL+R YDP G +T+D +L+
Sbjct: 1040 TYPARPDIQIFRDLCLTIRAGKTVALVGESGSGKSTVISLLQRFYDPDSGHITLDGVELK 1099
Query: 3248 QMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEY-THEQIETACSKANIHKFIDEL 3424
++ K LR+ + LV QEP+LF+ +IR NI YG E T +I A AN HKFI +
Sbjct: 1100 KLQLKWLRQQMGLVGQEPVLFNDTIRANIAYGKGSEEAATESEIIAAAELANAHKFISSI 1159
Query: 3425 PDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAA 3604
GY+T VGE+G QLSGGQKQR+AIARA+++ PKILLLDEATSALD ESE+ VQ ALD
Sbjct: 1160 QQGYDTVVGERGIQLSGGQKQRVAIARAIVKEPKILLLDEATSALDAESERVVQDALDRV 1219
Query: 3605 AKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFA 3748
+RT IVVAHRLSTI NA I VVKNG + E+GTH LI G +A
Sbjct: 1220 MVNRTTIVVAHRLSTIKNADVIAVVKNGVIAEKGTHETLIKIEGGVYA 1267
Score = 384 bits (985), Expect = e-104
Identities = 223/589 (37%), Positives = 326/589 (54%), Gaps = 10/589 (1%)
Frame = +2
Query: 89 MLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHEVIQ 268
+L +G + + G PL I++ V + F + +HE+ +
Sbjct: 709 VLLLGTVAAAINGAIFPLFGILISRVIEAFF---------------------KPAHELKR 747
Query: 269 N----CLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYDK--NT 430
+ + +V LG Q F V KL R R F + E+AW+D+ N+
Sbjct: 748 DSRFWAIIFVALGVTSLIVSPTQMYLFAVAGGKLIRRIRSMCFEKAVHMEVAWFDEPQNS 807
Query: 431 SGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMI 610
SGT+ +L + +R GD + LA Q +A G +AFT W L LI++ + P + I
Sbjct: 808 SGTMGARLSADATLIRALVGDALSLAVQNVASAASGLIIAFTASWELALIILVMLPLIGI 867
Query: 611 CGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKT 790
G +Y A +A + + SIRTV +F +E + Y+ E K
Sbjct: 868 NGFVQVKFMKGFSADAKSKYEEASQVANDAVGSIRTVASFCAEEKVMQMYKKQCEGPIKD 927
Query: 791 GIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQ 970
GIK+ F+ G G F I++ Y +F+ G V G+ V VFF++ M ++ + Q
Sbjct: 928 GIKQGFISGLGFGFSFFILFCVYATSFYAGARLVEDGKTTFNNVFQVFFALTMAAIGISQ 987
Query: 971 AGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADV 1150
+ A AAAS++ +IDR +ID+ G + G I + + FTYP R D+
Sbjct: 988 SSTFAPDSSKAKVAAASIFAIIDRKSKIDSSDETGTVLENVKGDIELRHLSFTYPARPDI 1047
Query: 1151 KILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLR 1330
+I + + L + G+TVALVG SG GKST+I LLQRFY+PD+G I +D + ++ +K+LR
Sbjct: 1048 QIFRDLCLTIRAGKTVALVGESGSGKSTVISLLQRFYDPDSGHITLDGVELKKLQLKWLR 1107
Query: 1331 QLVGVVSQEPNLFNTSIEQNIRYGRSD---VSDEDIARALKEANAADFIKTFPEGLNTLV 1501
Q +G+V QEP LFN +I NI YG+ ++ +I A + ANA FI + +G +T+V
Sbjct: 1108 QQMGLVGQEPVLFNDTIRANIAYGKGSEEAATESEIIAAAELANAHKFISSIQQGYDTVV 1167
Query: 1502 GDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIV 1681
G+RG+Q+SGGQKQR+AIARA+V+ PKILLLDEATSALDAESE +VQ AL+ RTTIV
Sbjct: 1168 GERGIQLSGGQKQRVAIARAIVKEPKILLLDEATSALDAESERVVQDALDRVMVNRTTIV 1227
Query: 1682 IAHRLSTVRNADKIIVMKAGQVMEVGTHETLIE-QKGLYHELVHAQVFA 1825
+AHRLST++NAD I V+K G + E GTHETLI+ + G+Y LV + A
Sbjct: 1228 VAHRLSTIKNADVIAVVKNGVIAEKGTHETLIKIEGGVYASLVQLHMTA 1276
>gi|15217786|ref|NP_171754.1| multidrug resistance P-glycoprotein,
putative [Arabidopsis thaliana]
Length = 1273
Score = 822 bits (2122), Expect = 0.0
Identities = 463/1259 (36%), Positives = 701/1259 (54%), Gaps = 23/1259 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+ +++L+ + + D ++ G + + GV LPLM+++ G++ +F
Sbjct: 28 VPLYKLFAFADSFDVFLMICGSLGAIGNGVCLPLMTLLFGDLIDSF-------------- 73
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
K + V + CLK+VYLG G A FLQ +C+M+ E+ + + R + +++R
Sbjct: 74 -GKNQNNKDIVDVVSKVCLKFVYLGLGRLGAAFLQVACWMITGERQAAKIRSNYLKTILR 132
Query: 401 QEIAWYDKNTS-GTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
Q+I ++D T+ G + ++ + +++ G+KVG Q+++ F+GGFA+AF WLLTL
Sbjct: 133 QDIGFFDVETNTGEVVGRMSGDTVHIQDAMGEKVGKFIQLVSTFVGGFALAFAKGWLLTL 192
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
+M++ PF+ + G YA A + E+ + SIRTV +F G++
Sbjct: 193 VMLTSIPFLAMAGAAMALLVTRASSRGQAAYAKAATVVEQTIGSIRTVASFTGEKQAINS 252
Query: 758 YEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFF 937
Y+ + K+ I++ F G GL + ++SY LA W G + G+V+ V
Sbjct: 253 YKKYITSAYKSSIQQGFSTGLGLGVMIYVFFSSYALAIWFGGKMILEKGYTGGSVINVII 312
Query: 938 SVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNK 1117
V+ GSM+LGQ AA ++E I R P IDAY G+ I G I +
Sbjct: 313 IVVAGSMSLGQTSPCVTAFAAGQAAAYKMFETIKRKPLIDAYDVNGKVLGDIRGDIELKD 372
Query: 1118 VEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDI 1297
V F+YP R D +I G SL G T ALVG SG GKST+I L++RFY+P AG++LID I
Sbjct: 373 VHFSYPARPDEEIFDGFSLFIPSGATAALVGESGSGKSTVINLIERFYDPKAGEVLIDGI 432
Query: 1298 PIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTF 1477
+++F +K++R +G+V QEP LF++SI +NI YG+ + + ++I A + ANAA FI
Sbjct: 433 NLKEFQLKWIRSKIGLVCQEPVLFSSSIMENIAYGKENATLQEIKVATELANAAKFINNL 492
Query: 1478 PEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENA 1657
P+GL+T VG+ G Q+SGGQKQRIAIARA++++P++LLLDEATSALD ESE +VQ AL+
Sbjct: 493 PQGLDTKVGEHGTQLSGGQKQRIAIARAILKDPRVLLLDEATSALDTESERVVQEALDRV 552
Query: 1658 SRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQK-GLYHELVHAQ-VFADV 1831
RTT+V+AHRLSTVRNAD I V+ +G+++E G+H L++ G Y +L+ Q +
Sbjct: 553 MVNRTTVVVAHRLSTVRNADMIAVIHSGKMVEKGSHSELLKDSVGAYSQLIRCQEINKGH 612
Query: 1832 DDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXX 2011
D KP M+ +S R ++N + S +
Sbjct: 613 DAKPSD------MASGSSFRNSNLNISREGSVISGGTSSFGNSSRHHSLNVLGLFAGLDL 666
Query: 2012 GA------------------VKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFF 2137
G+ K +L +I +PE I GA+ P F +
Sbjct: 667 GSGSQRVGQEETGTTSQEPLRKVSLTRIAALNKPEIPVLLLGTVVAAINGAIFPLFGILI 726
Query: 2138 SQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVY 2317
S++I F P DQ+KKD FWA++F+ L Q LF VA +L RI+S +
Sbjct: 727 SRVIEAFFKP-ADQLKKDSRFWAIIFVALGVTSLIVSPSQMYLFAVAGGKLIRRIQSMCF 785
Query: 2318 RNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYY 2497
+ + ++FD P++S G + RL+TDA I++ + L AS GL IAF
Sbjct: 786 EKAVHMEVSWFDEPENSSGTMGARLSTDAALIRALVGDALSLAVQNAASAASGLIIAFTA 845
Query: 2498 GWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQ 2677
W++A +++ + P + + L +K+ G + + E A + A +A+ +IRTV + +
Sbjct: 846 SWELALIILVMLPLIGINGFLQVKFMKGFSADAKSKYEEASQVANDAVGSIRTVASFCAE 905
Query: 2678 TKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEP 2857
K+ ++ + P + + I GL +GF+ I F YA +F L+ D
Sbjct: 906 EKVMQMYNKQCEGPIKDGVKQGFISGLGFGFSFFILFCVYATSFYAAARLVEDGKTTF-- 963
Query: 2858 ENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGT-YPQL 3034
+V +V FA++ + I ++++ P+ KA AA IF +++ + +ID +GT +
Sbjct: 964 IDVFQVFFALTMAAIGISQSSTFAPDSSKAKVAAASIFAIIDRKSKIDSSDETGTVLENV 1023
Query: 3035 SGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLE 3214
G+++L + F YP RP + I + L + ++ G+T+ALVG SG GKSTVISLL+R YDP
Sbjct: 1024 KGDIELRHLSFTYPARPGIQIFRDLCLTIRAGKTVALVGESGSGKSTVISLLQRFYDPDS 1083
Query: 3215 GAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGE-YTHEQIETACS 3391
G +T+D +L+++ K LR+ + LV QEP+LF+ +IR NI YG E T +I A
Sbjct: 1084 GQITLDGVELKKLQLKWLRQQMGLVGQEPVLFNDTIRANIAYGKGSEEAATESEIIAAAE 1143
Query: 3392 KANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTES 3571
AN HKFI + GY+T VGEKG QLSGGQKQR+AIARA+++ PKILLLDEATSALD ES
Sbjct: 1144 LANAHKFISSIQQGYDTVVGEKGIQLSGGQKQRVAIARAIVKEPKILLLDEATSALDAES 1203
Query: 3572 EKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFA 3748
E+ VQ ALD +RT +VVAHRLSTI NA I +VKNG + E GTH LI G +A
Sbjct: 1204 ERLVQDALDRVIVNRTTVVVAHRLSTIKNADVIAIVKNGVIAENGTHETLIKIDGGVYA 1262
Score = 372 bits (956), Expect = e-101
Identities = 217/585 (37%), Positives = 320/585 (54%), Gaps = 6/585 (1%)
Frame = +2
Query: 89 MLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHEVIQ 268
+L +G +V+ G PL I++ V + F P + + A
Sbjct: 704 VLLLGTVVAAINGAIFPLFGILISRVIE-------AFFKPADQLKKDSRFWA-------- 748
Query: 269 NCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYDK--NTSGTL 442
+ +V LG Q F V KL R + F + E++W+D+ N+SGT+
Sbjct: 749 --IIFVALGVTSLIVSPSQMYLFAVAGGKLIRRIQSMCFEKAVHMEVSWFDEPENSSGTM 806
Query: 443 SNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLF 622
+L + +R GD + LA Q A G +AFT W L LI++ + P + I G
Sbjct: 807 GARLSTDAALIRALVGDALSLAVQNAASAASGLIIAFTASWELALIILVMLPLIGINGFL 866
Query: 623 XXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKK 802
+Y A +A + + SIRTV +F +E + Y E K G+K+
Sbjct: 867 QVKFMKGFSADAKSKYEEASQVANDAVGSIRTVASFCAEEKVMQMYNKQCEGPIKDGVKQ 926
Query: 803 SFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQ 982
F+ G G F I++ Y +F+ V G+ V VFF++ M ++ + Q+
Sbjct: 927 GFISGLGFGFSFFILFCVYATSFYAAARLVEDGKTTFIDVFQVFFALTMAAIGISQSSTF 986
Query: 983 FATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILK 1162
A AAAS++ +IDR +ID+ G + G I + + FTYP R ++I +
Sbjct: 987 APDSSKAKVAAASIFAIIDRKSKIDSSDETGTVLENVKGDIELRHLSFTYPARPGIQIFR 1046
Query: 1163 GVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVG 1342
+ L + G+TVALVG SG GKST+I LLQRFY+PD+GQI +D + ++ +K+LRQ +G
Sbjct: 1047 DLCLTIRAGKTVALVGESGSGKSTVISLLQRFYDPDSGQITLDGVELKKLQLKWLRQQMG 1106
Query: 1343 VVSQEPNLFNTSIEQNIRYGRSD---VSDEDIARALKEANAADFIKTFPEGLNTLVGDRG 1513
+V QEP LFN +I NI YG+ ++ +I A + ANA FI + +G +T+VG++G
Sbjct: 1107 LVGQEPVLFNDTIRANIAYGKGSEEAATESEIIAAAELANAHKFISSIQQGYDTVVGEKG 1166
Query: 1514 VQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHR 1693
+Q+SGGQKQR+AIARA+V+ PKILLLDEATSALDAESE +VQ AL+ RTT+V+AHR
Sbjct: 1167 IQLSGGQKQRVAIARAIVKEPKILLLDEATSALDAESERLVQDALDRVIVNRTTVVVAHR 1226
Query: 1694 LSTVRNADKIIVMKAGQVMEVGTHETLIE-QKGLYHELVHAQVFA 1825
LST++NAD I ++K G + E GTHETLI+ G+Y LV + A
Sbjct: 1227 LSTIKNADVIAIVKNGVIAENGTHETLIKIDGGVYASLVQLHMTA 1271
Score = 335 bits (858), Expect = 7e-90
Identities = 203/567 (35%), Positives = 315/567 (54%), Gaps = 6/567 (1%)
Frame = +2
Query: 2105 GAVMPAFSLFFSQIINVFSNPDRDQMKKD----GHFWALMFLVLAAVQGTSMLFQCSLFG 2272
G +P +L F +I+ F ++Q KD L F+ L + + Q + +
Sbjct: 56 GVCLPLMTLLFGDLIDSFG---KNQNNKDIVDVVSKVCLKFVYLGLGRLGAAFLQVACWM 112
Query: 2273 VAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFN 2452
+ ER +IRS + +LRQD +FD+ ++ G + R++ D +I+ A+ ++G
Sbjct: 113 ITGERQAAKIRSNYLKTILRQDIGFFDVETNT-GEVVGRMSGDTVHIQDAMGEKVGKFIQ 171
Query: 2453 AIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAM 2632
+++ GG +AF GW + +++ PF+A+ A M +++ A
Sbjct: 172 LVSTFVGGFALAFAKGWLLTLVMLTSIPFLAMAGAAMALLVTRASSRGQAAYAKAATVVE 231
Query: 2633 EAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFR 2812
+ I +IRTV + T + + N + ++ + + +I + GL G + F +YA A
Sbjct: 232 QTIGSIRTVASFTGEKQAINSYKKYITSAYKSSIQQGFSTGLGLGVMIYVFFSSYALAIW 291
Query: 2813 FGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEP 2992
FG +I +K +V+ V+ + ++G + + AA +F ++ +P
Sbjct: 292 FGGKMILEKGYT--GGSVINVIIIVVAGSMSLGQTSPCVTAFAAGQAAAYKMFETIKRKP 349
Query: 2993 RIDGMTSSG-TYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGK 3169
ID +G + G+++L V F YP RP I G ++ + G T ALVG SG GK
Sbjct: 350 LIDAYDVNGKVLGDIRGDIELKDVHFSYPARPDEEIFDGFSLFIPSGATAALVGESGSGK 409
Query: 3170 STVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQ 3349
STVI+L+ER YDP G V +D +L++ K +R I LV QEP+LF +SI ENI YG +
Sbjct: 410 STVINLIERFYDPKAGEVLIDGINLKEFQLKWIRSKIGLVCQEPVLFSSSIMENIAYGKE 469
Query: 3350 PGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKI 3529
T ++I+ A AN KFI+ LP G +T+VGE GTQLSGGQKQRIAIARA++++P++
Sbjct: 470 NA--TLQEIKVATELANAAKFINNLPQGLDTKVGEHGTQLSGGQKQRIAIARAILKDPRV 527
Query: 3530 LLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGT 3709
LLLDEATSALDTESE+ VQ ALD +RT +VVAHRLST+ NA I V+ +G++VE+G+
Sbjct: 528 LLLDEATSALDTESERVVQEALDRVMVNRTTVVVAHRLSTVRNADMIAVIHSGKMVEKGS 587
Query: 3710 HNELIAKR-GAYFALTQKQSSNQSGGA 3787
H+EL+ GAY L + Q N+ A
Sbjct: 588 HSELLKDSVGAYSQLIRCQEINKGHDA 614
>gi|50750485|ref|XP_422016.1| PREDICTED: similar to liver bile salt
export pump [Gallus gallus]
Length = 1371
Score = 820 bits (2117), Expect = 0.0
Identities = 468/1104 (42%), Positives = 650/1104 (58%), Gaps = 7/1104 (0%)
Frame = +2
Query: 461 NLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXXXXXX 640
++ ++ E D+V + Q + F+ GF + F W LTL+++++SP + +
Sbjct: 295 DVNKINEAIADQVAIFIQRLTTFVCGFLLGFISGWKLTLVIIAVSPLIGVGAAVYGLAVA 354
Query: 641 XXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFLIGA 820
YA AG +A+EVL+SIRTV AF G++ E +RY+ L + + GI+K ++G
Sbjct: 355 KLTGRELKAYAKAGAVADEVLSSIRTVAAFGGEKKEVERYDKNLVYAQHWGIRKGIIMGL 414
Query: 821 GLASFFVIIYASYCLAFWVGTNFVYS-GRLESGTVLTVFFSVMMGSMALGQAGQQFATIG 997
+ +I+ Y LAFW G+ V GT+L VFF V++G++ LGQA
Sbjct: 415 FSGYMWFVIFLCYALAFWYGSKLVLEEDEYSPGTLLQVFFGVLVGALNLGQASPCLEAFA 474
Query: 998 TALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKGVSLD 1177
T GAAA+++E IDR P ID S EG K+ G I + V F YP+R DVKIL +S+
Sbjct: 475 TGRGAAANIFETIDRKPTIDCMSEEGYKLDKVRGEIEFHNVTFHYPSRPDVKILDNISMV 534
Query: 1178 AQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQE 1357
+ G+T A VG+SG GKSTIIQL+QRFY+P G I +D I NI++LR +GVV QE
Sbjct: 535 IKTGETTAFVGASGAGKSTIIQLIQRFYDPTDGMITLDGHDIRSLNIQWLRAQIGVVEQE 594
Query: 1358 PNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQK 1537
P LF T+I +NIRYGR D + ED+ RA K+ANA FI P+ +T VG+ G QMSGGQK
Sbjct: 595 PVLFATTIAENIRYGRDDATMEDVIRAAKQANAYKFIMDLPQQFDTHVGEGGSQMSGGQK 654
Query: 1538 QRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLSTVRNAD 1717
QRIAIARALVRNPKILLLD ATSALD ESE+IVQ AL+ A GRT I IAHRLS V+ AD
Sbjct: 655 QRIAIARALVRNPKILLLDMATSALDNESEAIVQEALQKAHLGRTAISIAHRLSAVKAAD 714
Query: 1718 KIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVDDKPKKKEAERRMSRQTSQRKG 1897
II + G+ +E GTHE L+++KG+Y LV Q D S T K
Sbjct: 715 VIIGFEHGRAVERGTHEELLKRKGVYFMLVTLQSKGD--------------STLTRAAKE 760
Query: 1898 SVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXGAVKANLFKILRYARPEWIYXX 2077
S K E ++ G+ +A+L LR +
Sbjct: 761 SAENKVVEPNLEKVQSFRR-------------------GSYRASLRASLRQRSRSQLSNV 801
Query: 2078 XXXXXXLIQG-----AVMPAFSLFFSQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGT 2242
I G + ++ Q FS D ++ K + L+F+++ V
Sbjct: 802 VPDPPLSIAGDQAESVYLKSYEEDDGQAKKTFSILDEEKQKVQINGVCLLFVLVGIVSFF 861
Query: 2243 SMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSA 2422
+ Q F + E LT R+R ++ +L QD +FD ++SPG +TTRLATDA ++ A
Sbjct: 862 TQFLQGYNFAKSGELLTRRLRKIGFQAMLGQDVGWFDDRRNSPGALTTRLATDASQVQGA 921
Query: 2423 IDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAK 2602
++G + N+ ++G + IAFY+ W+++ ++M PF+A+ A+ K G A D K
Sbjct: 922 TGSQIGMMVNSFTNIGVAIIIAFYFSWKLSLVIMCFLPFLALSGAVQAKMLTGFAAQDKK 981
Query: 2603 EMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSI 2782
+E G+ + EA+ NIRTV + + K + F +LD P+ I KA + G+ +GFA SI
Sbjct: 982 ALEATGQISSEALSNIRTVAGIGKEKKFIDAFEKNLDMPYRAAIKKANVYGICFGFAQSI 1041
Query: 2783 QFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAG 2962
F + ++R+G FL+ + + V RV+ AI S +G A+SY P Y KA +A
Sbjct: 1042 VFIANSVSYRYGGFLVQTEG--LHYSFVFRVISAIVTSGTALGRASSYTPNYAKAKTSAA 1099
Query: 2963 LIFNMLEEEPRIDGMTSSGT-YPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTL 3139
+F +++ P+I + G + G ++ F YP RP + +L+GL+V VKPGQTL
Sbjct: 1100 RLFQLIDRLPKISVYSKEGEKWDDFKGSIEFLNCKFTYPSRPDIQVLKGLSVAVKPGQTL 1159
Query: 3140 ALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTS 3319
A VG SGCGKST + LLER YDP EG+V +D +D +++N + LR I +VSQEP+LFD S
Sbjct: 1160 AFVGSSGCGKSTSVQLLERFYDPEEGSVLIDGHDTKKVNVQFLRSKIGVVSQEPVLFDCS 1219
Query: 3320 IRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAI 3499
I +NI YG + T E++ A KA +H F+ LP+ YET VG +G+QLS GQKQRIAI
Sbjct: 1220 IADNIKYGSNTKDTTMEKVIEAAKKAQLHDFVMSLPEKYETNVGAQGSQLSRGQKQRIAI 1279
Query: 3500 ARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVV 3679
ARA+IR+PKILLLDEATSALDTESEK VQ ALD A + RTCIV+AHRLSTI NA I V+
Sbjct: 1280 ARAIIRDPKILLLDEATSALDTESEKTVQAALDKAREGRTCIVIAHRLSTIENADIIAVM 1339
Query: 3680 KNGQVVEQGTHNELIAKRGAYFAL 3751
G ++E+GTH+EL+A GAY+ L
Sbjct: 1340 SQGIIIERGTHDELMAMEGAYYKL 1363
Score = 370 bits (950), Expect = e-100
Identities = 204/516 (39%), Positives = 301/516 (57%), Gaps = 4/516 (0%)
Frame = +2
Query: 272 CLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYD--KNTSGTLS 445
CL +V +G F FLQ F E L+ R R+ F +++ Q++ W+D +N+ G L+
Sbjct: 849 CLLFVLVGIVSFFTQFLQGYNFAKSGELLTRRLRKIGFQAMLGQDVGWFDDRRNSPGALT 908
Query: 446 NKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFX 625
+L + +V+ TG ++G+ +AF + W L+L++M PF+ + G
Sbjct: 909 TRLATDASQVQGATGSQIGMMVNSFTNIGVAIIIAFYFSWKLSLVIMCFLPFLALSGAVQ 968
Query: 626 XXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKS 805
G I+ E L++IRTV ++ +E L+ + IKK+
Sbjct: 969 AKMLTGFAAQDKKALEATGQISSEALSNIRTVAGIGKEKKFIDAFEKNLDMPYRAAIKKA 1028
Query: 806 FLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQF 985
+ G I++ + +++ G V + L V V +++ ALG+A
Sbjct: 1029 NVYGICFGFAQSIVFIANSVSYRYGGFLVQTEGLHYSFVFRVISAIVTSGTALGRASSYT 1088
Query: 986 ATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKG 1165
A +AA L+++IDR+P+I YS EG+ G I +FTYP+R D+++LKG
Sbjct: 1089 PNYAKAKTSAARLFQLIDRLPKISVYSKEGEKWDDFKGSIEFLNCKFTYPSRPDIQVLKG 1148
Query: 1166 VSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGV 1345
+S+ +PGQT+A VGSSGCGKST +QLL+RFY+P+ G +LID + N+++LR +GV
Sbjct: 1149 LSVAVKPGQTLAFVGSSGCGKSTSVQLLERFYDPEEGSVLIDGHDTKKVNVQFLRSKIGV 1208
Query: 1346 VSQEPNLFNTSIEQNIRYGRS--DVSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQ 1519
VSQEP LF+ SI NI+YG + D + E + A K+A DF+ + PE T VG +G Q
Sbjct: 1209 VSQEPVLFDCSIADNIKYGSNTKDTTMEKVIEAAKKAQLHDFVMSLPEKYETNVGAQGSQ 1268
Query: 1520 MSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLS 1699
+S GQKQRIAIARA++R+PKILLLDEATSALD ESE VQ+AL+ A GRT IVIAHRLS
Sbjct: 1269 LSRGQKQRIAIARAIIRDPKILLLDEATSALDTESEKTVQAALDKAREGRTCIVIAHRLS 1328
Query: 1700 TVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELV 1807
T+ NAD I VM G ++E GTH+ L+ +G Y++LV
Sbjct: 1329 TIENADIIAVMSQGIIIERGTHDELMAMEGAYYKLV 1364
Score = 316 bits (809), Expect = 3e-84
Identities = 201/568 (35%), Positives = 287/568 (50%), Gaps = 59/568 (10%)
Frame = +2
Query: 2252 FQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPK---------HSPGRITTRLAT-- 2398
FQ + +AA R +IR +RNV+R D +FD HSP + L
Sbjct: 188 FQICFWVMAAARQIQKIRKAYFRNVMRMDIGWFDCTSQYYIPPLFSHSPSYLENELPGVR 247
Query: 2399 -----------------------------------------------DAPNIKSAIDYRL 2437
D I AI ++
Sbjct: 248 LNDEESYSPPPTSSARLHLVLYNAISVILAASCCDVSAPSASAGAQGDVNKINEAIADQV 307
Query: 2438 GSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENA 2617
+ + G + F GW++ +++A+ P + VG A+ + K A
Sbjct: 308 AIFIQRLTTFVCGFLLGFISGWKLTLVIIAVSPLIGVGAAVYGLAVAKLTGRELKAYAKA 367
Query: 2618 GKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTY 2797
G A E + +IRTV A + K + +L I K II GL G+ + F Y
Sbjct: 368 GAVADEVLSSIRTVAAFGGEKKEVERYDKNLVYAQHWGIRKGIIMGLFSGYMWFVIFLCY 427
Query: 2798 AAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNM 2977
A AF +G L+ +++ P +L+V F + +G A+ + AA IF
Sbjct: 428 ALAFWYGSKLVLEEDEY-SPGTLLQVFFGVLVGALNLGQASPCLEAFATGRGAAANIFET 486
Query: 2978 LEEEPRIDGMTSSG-TYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGP 3154
++ +P ID M+ G ++ GE++ + V F YP RP V IL +++ +K G+T A VG
Sbjct: 487 IDRKPTIDCMSEEGYKLDKVRGEIEFHNVTFHYPSRPDVKILDNISMVIKTGETTAFVGA 546
Query: 3155 SGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENI 3334
SG GKST+I L++R YDP +G +T+D +D+R +N + LR I +V QEP+LF T+I ENI
Sbjct: 547 SGAGKSTIIQLIQRFYDPTDGMITLDGHDIRSLNIQWLRAQIGVVEQEPVLFATTIAENI 606
Query: 3335 VYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALI 3514
YG + T E + A +AN +KFI +LP ++T VGE G+Q+SGGQKQRIAIARAL+
Sbjct: 607 RYGRD--DATMEDVIRAAKQANAYKFIMDLPQQFDTHVGEGGSQMSGGQKQRIAIARALV 664
Query: 3515 RNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQV 3694
RNPKILLLD ATSALD ESE VQ AL A RT I +AHRLS + A I+ ++G+
Sbjct: 665 RNPKILLLDMATSALDNESEAIVQEALQKAHLGRTAISIAHRLSAVKAADVIIGFEHGRA 724
Query: 3695 VEQGTHNELIAKRGAYFALTQKQSSNQS 3778
VE+GTH EL+ ++G YF L QS S
Sbjct: 725 VERGTHEELLKRKGVYFMLVTLQSKGDS 752
Score = 56.6 bits (135), Expect = 4e-06
Identities = 34/148 (22%), Positives = 63/148 (41%), Gaps = 21/148 (14%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGT---IFLDPN 211
+ FQL+R++S ++ LM+ VG + G P M ++ G ++ F+ DPN
Sbjct: 74 VGFFQLFRFSSPMEILMMVVGSFCAILHGAAQPGMLLVFGAMADTFIEYDVEMQALKDPN 133
Query: 212 STA--------------SEKAAARA----EFSHEVIQNCLKYVYLGCGIFAAGFLQASCF 337
T +EK + E+ Y +GC + G+ Q +
Sbjct: 134 KTCINNTIVWINGTVHQNEKNTTTRCGLLDIEKEMTNFAAYYGGIGCAVLLLGYFQICFW 193
Query: 338 MVICEKLSNRFRRQFFHSVMRQEIAWYD 421
++ + + R+ +F +VMR +I W+D
Sbjct: 194 VMAAARQIQKIRKAYFRNVMRMDIGWFD 221
>gi|34894326|ref|NP_908488.1| unnamed protein product [Oryza sativa
(japonica cultivar-group)]
gi|8468012|dbj|BAA96612.1| unnamed protein product [Oryza sativa
(japonica cultivar-group)]
gi|27368863|emb|CAD59589.1| MDR-like ABC transporter [Oryza sativa
(japonica cultivar-group)]
Length = 1285
Score = 820 bits (2117), Expect = 0.0
Identities = 469/1256 (37%), Positives = 708/1256 (56%), Gaps = 10/1256 (0%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+ +L+ + D ++A+G + + A G LP M+++ GN+ F
Sbjct: 54 VPFHKLFAFADKTDAALMALGTLGAVANGAALPFMTVLFGNLIDAF-------------- 99
Query: 221 SEKAAARAEFSHEVIQNC----LKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFH 388
A H+V+ L+++YL A F+Q +C+M+ E+ + R R +
Sbjct: 100 -----GGAMGIHDVVNRVSMVSLEFIYLAIASAVASFVQVTCWMITGERQAARIRNLYLK 154
Query: 389 SVMRQEIAWYDKNTS-GTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDW 565
+++RQEIA++DK T+ G + ++ + +++ G+KVG Q++ F+GGF VAF W
Sbjct: 155 TILRQEIAFFDKYTNTGEVVGRMSGDTVLIQDAMGEKVGKFIQLVVTFLGGFIVAFAQGW 214
Query: 566 LLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEY 745
LLTL+MM+ P +++ G YA + + E+ + SIRTV +F G++
Sbjct: 215 LLTLVMMATIPPLVVAGAVMSNVVAKMASLGQAAYAESSVVVEQTIGSIRTVASFTGEKQ 274
Query: 746 ECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVL 925
++Y +L+ K+G+++ G G+ + V+++ Y L W G + V+
Sbjct: 275 AVEKYNKSLKSAYKSGVREGLAAGLGMGTVMVLLFCGYSLGIWYGAKLILLKGYTGAKVM 334
Query: 926 TVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRI 1105
V F+V+ GS+ALGQA AA ++E I+R PEIDAYST G P I G I
Sbjct: 335 NVIFAVLTGSLALGQASPSMKAFAGGQAAAYKMFETINRKPEIDAYSTTGMKPDDIRGDI 394
Query: 1106 SVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQIL 1285
V F+YPTR D +I +G SL G TVALVG SG GKST+I L++RFY+P G +L
Sbjct: 395 EFRDVYFSYPTRPDEQIFRGFSLSIPSGTTVALVGQSGSGKSTVISLIERFYDPQLGDVL 454
Query: 1286 IDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADF 1465
ID + +++F ++++R +G+VSQEP LF SI++NI YG+ + +D++I A + ANA+ F
Sbjct: 455 IDGVNLKEFQLRWIRSKIGLVSQEPVLFAASIKENIAYGKDNATDQEIRAAAELANASKF 514
Query: 1466 IKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSA 1645
I P+GL+T VG+ G Q+SGGQKQRIAIARA++++P+ILLLDEATSALDAESE IVQ A
Sbjct: 515 IDKMPQGLDTSVGEHGTQLSGGQKQRIAIARAILKDPRILLLDEATSALDAESERIVQEA 574
Query: 1646 LENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGT-HETLIEQKGLYHELVHAQVF 1822
L+ RTT+++AHRLSTVRNAD I V+ G ++E G HE L + +G Y +L+ Q
Sbjct: 575 LDRVMTNRTTVIVAHRLSTVRNADTIAVIHQGTLVEKGPHHELLKDPEGAYSQLIKLQEA 634
Query: 1823 ADVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXX 2002
D +K ++ R +Q S + + +
Sbjct: 635 NRQDKSDRKGDSGARSGKQLSINQSASRSRRSSRDNSHHSFSVPFGMPLGIDIQDGSSDN 694
Query: 2003 XXXGAVK-ANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQ 2179
G + L ++ +PE +I G + P F++ S +I F P
Sbjct: 695 LCDGMPQDVPLSRLASLNKPEIPVLILGSIASVISGVIFPIFAILLSNVIKAFYEPPH-L 753
Query: 2180 MKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMP 2359
++KD FW+ MFLV AV S+ LF +A RL RIR + V+ + +FD P
Sbjct: 754 LRKDSQFWSSMFLVFGAVYFLSLPVSSYLFSIAGCRLIKRIRLMTFEKVVNMEIEWFDHP 813
Query: 2360 KHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPF 2539
++S G I RL+ DA ++ + L + ++ GL IAF W+++ +++A+ P
Sbjct: 814 ENSSGAIGARLSADAAKVRGLVGDALQLVVQNTTTLIAGLVIAFVSNWELSLIILALIPL 873
Query: 2540 MAVGQALMMKYHGGSATSDAKEM-ENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDA 2716
+ + + MK+ G ++DAK M E A + A +A+ +IRTV + + + K+ +++ +
Sbjct: 874 IGLNGWIQMKFIQG-FSADAKMMYEEASQVANDAVSSIRTVVSFSAEEKVMDLYKKKCEG 932
Query: 2717 PHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFS 2896
P I II G+ +G + + F YAA+F G L+ ++N P+ V RV A++ +
Sbjct: 933 PLRTGIRTGIISGIGFGVSFFLLFGVYAASFYAGARLV-EENKTTFPK-VFRVFLALAMA 990
Query: 2897 FGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSG-TYPQLSGEVKLNKVFFRY 3073
+ +++ + KA A IF +++ + RID +G T L G ++ V FRY
Sbjct: 991 AIGVSQSSTLTSDSSKAKSAVSSIFAIVDRKSRIDPSEDAGVTVETLHGNIEFQHVSFRY 1050
Query: 3074 PERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQM 3253
P RP V I + L + + G+T+ALVG SG GKST ISLL+R YDP G + +D D+++
Sbjct: 1051 PTRPDVEIFRDLCLTIHSGKTVALVGESGSGKSTAISLLQRFYDPDVGHILLDGVDIQKF 1110
Query: 3254 NPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDG 3433
K LR+ + LVSQEP LF+ ++R NI YG + GE T +I A AN HKFI G
Sbjct: 1111 QLKWLRQQMGLVSQEPALFNDTVRANIAYG-KEGEATESEIIEAAKLANAHKFISSSHQG 1169
Query: 3434 YETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKD 3613
Y T VGE+G QLSGGQKQRIAIARA++++PKILLLDEATSALD ESE+ VQ ALD +
Sbjct: 1170 YGTTVGERGAQLSGGQKQRIAIARAIVKDPKILLLDEATSALDAESERVVQDALDRVMVN 1229
Query: 3614 RTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELI-AKRGAYFALTQKQSSNQS 3778
RT ++VAHRLSTI NA I VVKNG ++E+G H+ L+ K GAY +L S+ S
Sbjct: 1230 RTTVIVAHRLSTIQNADLIAVVKNGVIIEKGKHDTLMNIKDGAYASLVALHSAASS 1285
>gi|27368865|emb|CAD59590.1| MDR-like ABC transporter [Oryza sativa
(japonica cultivar-group)]
gi|46485796|gb|AAS98421.1| MDR-like ABC transporter [Oryza sativa
(japonica cultivar-group)]
Length = 1276
Score = 820 bits (2117), Expect = 0.0
Identities = 465/1248 (37%), Positives = 703/1248 (56%), Gaps = 11/1248 (0%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
++ +L+ + D ++ +G + + A G LP M+++ G + F
Sbjct: 39 VAFHRLFAFADGTDAALMLLGTLGAVANGAALPFMTVLFGGLIDAF-------------- 84
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
AA + V + L+++YL AA F+Q +C+M+ E+ + R R + +++R
Sbjct: 85 --GGAAGGDVVARVSEVSLQFIYLAVASAAASFIQVACWMITGERQAARIRSLYLRTILR 142
Query: 401 QEIAWYDKNTS-GTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
QE+A++DK+T+ G + ++ + +++ G+KVG Q++ F+GGF VAF WLLTL
Sbjct: 143 QEVAFFDKHTNTGEVVGRMSGDTVLIQDAMGEKVGKFVQLLVTFLGGFGVAFAQGWLLTL 202
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
+M++ P +++ G YA A + E+ + SIRTV +F G++ +
Sbjct: 203 VMLATIPPLVLSGAVMSNVVARMASLGQAAYADASVVVEQTIGSIRTVASFTGEKQAVAK 262
Query: 758 YEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFF 937
Y +L+ +G+++ G G+ + V+++ Y L W G + V+ V F
Sbjct: 263 YSRSLKRAYSSGVREGLAAGVGMGTVMVLLFCGYSLGIWYGAKLILEKGYTGAQVMNVIF 322
Query: 938 SVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNK 1117
+V+ GS+ALGQA AA ++E I+R PEIDAYS G+ I G I
Sbjct: 323 AVLTGSLALGQASPSMKAFAGGQAAAYKMFETINREPEIDAYSATGRKLDDIQGDIEFRN 382
Query: 1118 VEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDI 1297
V F+YPTR D +I +G SL Q G TVALVG SG GKST+I L++RFY+P G++LID +
Sbjct: 383 VYFSYPTRPDEQIFRGFSLAIQSGTTVALVGQSGSGKSTVISLIERFYDPQLGEVLIDGV 442
Query: 1298 PIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTF 1477
+++ ++++R +G+VSQEP LF SI NI YGR + ++++I A + ANA+ FI
Sbjct: 443 NLKELQLRWIRSKIGLVSQEPILFAASIIDNIAYGRDNATNQEIRAAAELANASKFIDKM 502
Query: 1478 PEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENA 1657
P+G TLVG+ G Q+SGGQKQRIAIARA++++P+ILLLDEATSALD ESE IVQ AL+
Sbjct: 503 PQGFATLVGEHGTQLSGGQKQRIAIARAILKDPRILLLDEATSALDTESERIVQEALDRV 562
Query: 1658 SRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLI-EQKGLYHELV------HAQ 1816
RTT+++AHRL+TVRNAD I V+ G ++E G+H LI + G Y +L+ H
Sbjct: 563 MSNRTTVIVAHRLTTVRNADTIAVIHQGSIVEKGSHHELISDPDGAYSQLIRLQENSHDS 622
Query: 1817 VFADVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXX 1996
A+ +K KK S + S S ++ +
Sbjct: 623 EDANYQNKSGKKSDSGIRSGKQSFSYQSTPQRSSRDNSNNHSFSVSATPLEIDVQGGSPK 682
Query: 1997 XXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRD 2176
+ L ++ +PE + G + P F++ S +I F P +
Sbjct: 683 KIAEETPQEVPLSRLAALNKPEIPVLLLGSVASAVSGVIFPIFAILLSNVIKAFYEPPQ- 741
Query: 2177 QMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDM 2356
+KKD FW+ MFLV AV S+ LF VA RL RIR + V+ + +FD
Sbjct: 742 VLKKDAEFWSSMFLVFGAVYFLSLPIGSYLFSVAGCRLIRRIRLMTFEKVVNMEIEWFDH 801
Query: 2357 PKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFP 2536
P++S G I RL+ DA I+ + L + +A++ GL IAF W+++ +++A+ P
Sbjct: 802 PENSSGSIGARLSADAAKIRGLVGDALQLVVQNLATLVAGLLIAFISNWELSLIILALIP 861
Query: 2537 FMAVGQALMMKYHGGSATSDAKEM-ENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLD 2713
+ V + MK+ G ++DAK M E A + A +A+ +IRTV + + + K+ +++ +
Sbjct: 862 LIGVNGWIQMKFIQG-FSADAKMMYEEASQVANDAVSSIRTVASFSAEEKVMDLYKMKCE 920
Query: 2714 APHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISF 2893
P I AII G+ +G + + F YAA+F G L+ D+ NV RV A++
Sbjct: 921 GPLRTGIRTAIISGIGFGVSIFLLFGVYAASFYAGARLVEDRKTTF--PNVFRVFLALTM 978
Query: 2894 SFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSG-TYPQLSGEVKLNKVFFR 3070
+ + ++ + KA A IF +++ + RID +G + L G+++ V FR
Sbjct: 979 AAIGVSHTSNLTSDSSKAKSAVSSIFAIVDRKSRIDPSDDAGVSLEPLRGDIEFQHVSFR 1038
Query: 3071 YPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQ 3250
YP RP V I + L + ++ G+T+ALVG SG GKST ISLL+R YDP G + +D D+++
Sbjct: 1039 YPTRPDVQIFEDLCLTIQSGKTVALVGESGSGKSTAISLLQRFYDPDAGHILLDGVDIQK 1098
Query: 3251 MNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPD 3430
+ LR+ + LVSQEP LF+ +IR NI YG + G+ T I ++ AN HKFI L
Sbjct: 1099 FQLRWLRQQMGLVSQEPALFNDTIRANIAYG-KEGDATESDIVSSAQLANAHKFISSLHQ 1157
Query: 3431 GYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAK 3610
GYET VGE+G QLSGGQKQRIAIARA++++PKILLLDEATSALD ESE+ VQ ALD
Sbjct: 1158 GYETMVGERGAQLSGGQKQRIAIARAIVKDPKILLLDEATSALDAESERVVQDALDRVMM 1217
Query: 3611 DRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIA-KRGAYFAL 3751
+RT ++VAHRLSTI A I VVKNG ++E+G H+ LI K GAY +L
Sbjct: 1218 NRTTVIVAHRLSTIQGADMIAVVKNGMIIEKGKHDALIGIKDGAYASL 1265
>gi|15234322|ref|NP_192091.1| multidrug resistance P-glycoprotein,
putative [Arabidopsis thaliana]
gi|25297452|pir||D85023 P-glycoprotein-like protein pgp3 [imported] -
Arabidopsis thaliana
gi|4558551|gb|AAD22644.1| P-glycoprotein-like protein [Arabidopsis
thaliana]
gi|7268566|emb|CAB80675.1| P-glycoprotein-like protein pgp3
[Arabidopsis thaliana]
Length = 1229
Score = 817 bits (2111), Expect = 0.0
Identities = 473/1252 (37%), Positives = 707/1252 (55%), Gaps = 6/1252 (0%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+ ++L+ ++ + D L++ VG I + GVG PLM+++ G++ +
Sbjct: 8 VPFYKLFSFSDSTDVLLMIVGSIGAIGNGVGFPLMTLLFGDLIDSI----------GQNQ 57
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
S K + V + CLK+VYLG G A FLQ +C+M+ E+ + R R + +++R
Sbjct: 58 SNK-----DIVEIVSKVCLKFVYLGLGTLGAAFLQVACWMITGERQAARIRSLYLKTILR 112
Query: 401 QEIAWYDKNTS-GTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
Q+I ++D TS G + ++ + + E G+KVG Q++A F+GGF +AF WLLTL
Sbjct: 113 QDIGFFDVETSTGEVVGRMSGDTVLILEAMGEKVGKFIQLIATFVGGFVLAFVKGWLLTL 172
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
+M+ P + I G YA A + E+ L SIRTV +F G++ K
Sbjct: 173 VMLVSIPLLAIAGAAMPIIVTRASSREQAAYAKASTVVEQTLGSIRTVASFTGEKQAMKS 232
Query: 758 YEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFF 937
Y + + + +K+ F +G GL F + + SY LA W G + G V+ V
Sbjct: 233 YREFINLAYRASVKQGFSMGLGLGVVFFVFFCSYALAIWFGGEMILKKGYTGGEVVNVMV 292
Query: 938 SVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNK 1117
+V+ SM+LGQ AA ++E I+R P IDA+ G+ I G I +
Sbjct: 293 TVVASSMSLGQTTPCLTAFAAGKAAAYKMFETIERKPSIDAFDLNGKVLEDIRGEIELRD 352
Query: 1118 VEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDI 1297
V F+YP R ++ G SL G T ALVG SG GKS++I L++RFY+P +G +LID +
Sbjct: 353 VCFSYPARPMEEVFGGFSLLIPSGATAALVGESGSGKSSVISLIERFYDPSSGSVLIDGV 412
Query: 1298 PIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTF 1477
+++F +K++R +G+VSQEP LF++SI +NI YG+ + + E+I A K ANAA+FI
Sbjct: 413 NLKEFQLKWIRGKIGLVSQEPVLFSSSIMENIGYGKENATVEEIQAAAKLANAANFIDKL 472
Query: 1478 PEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENA 1657
P GL TLVG+ G Q+SGGQKQRIAIARA++++P+ILLLDEATSALDAESE +VQ AL+
Sbjct: 473 PRGLETLVGEHGTQLSGGQKQRIAIARAILKDPRILLLDEATSALDAESERVVQEALDRV 532
Query: 1658 SRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTH-ETLIEQKGLYHELVHAQVFADVD 1834
RTT+++AHRLSTVRNAD I V+ G+++E G+H E L + +G Y +L+ Q +
Sbjct: 533 MMSRTTVIVAHRLSTVRNADMIAVIHRGKIVEEGSHSELLKDHEGAYAQLIRLQ---KIK 589
Query: 1835 DKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXG 2014
+PK+ E+ + ++ R S N +T+ D
Sbjct: 590 KEPKRLESSNELRDRSINRGSSRNIRTRVHDDDSVSVLGLLGRQENTEISREQSR----- 644
Query: 2015 AVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDG 2194
++ +I +PE + G + P F + F+++I F P D MK+D
Sbjct: 645 --NVSITRIAALNKPETTILILGTLLGAVNGTIFPIFGILFAKVIEAFFKPPHD-MKRDS 701
Query: 2195 HFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPG 2374
FW+++F++L LF VA RL RIR + V+ + +FD P++S G
Sbjct: 702 RFWSMIFVLLGVASLIVYPMHTYLFAVAGGRLIQRIRVMCFEKVVHMEVGWFDDPENSSG 761
Query: 2375 RITTRLATDAPNIKSAIDYRLG-SIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVG 2551
I +RL+ DA IK+ + L S+ NA A+V GL IAF W++A +++ + P + +
Sbjct: 762 TIGSRLSADAALIKTLVGDSLSLSVKNAAAAV-SGLIIAFTASWKLAVIILVMIPLIGIN 820
Query: 2552 QALMMKYHGGSATSDAK-EMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGG 2728
L +K+ G T+DAK + E A + A +A+ +IRTV + + K+ ++ +
Sbjct: 821 GYLQIKFIKG-FTADAKAKYEEASQVANDAVGSIRTVASFCAEEKVMEMYKKRCEDTIKS 879
Query: 2729 NISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTI 2908
I + +I G+ +G + + + YA+ F G L+ K +V +V A++ + I
Sbjct: 880 GIKQGLISGVGFGISFFVLYSVYASCFYVGARLV--KAGRTNFNDVFQVFLALTMTAIGI 937
Query: 2909 GFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSG-TYPQLSGEVKLNKVFFRYPERP 3085
A+S+ P+ KA AA IF +++ + ID SG + G+++L + F Y RP
Sbjct: 938 SQASSFAPDSSKAKGAAASIFGIIDGKSMIDSRDESGLVLENVKGDIELCHISFTYQTRP 997
Query: 3086 AVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKH 3265
V I + L ++ GQT+ALVG SG GKSTVISLL+R YDP G +T+D +L+++ K
Sbjct: 998 DVQIFRDLCFAIRAGQTVALVGESGSGKSTVISLLQRFYDPDSGHITLDRVELKKLQLKW 1057
Query: 3266 LRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETR 3445
+R+ + LV QEP+LF+ +IR NI YG E + +I A AN H FI + GY+T
Sbjct: 1058 VRQQMGLVGQEPVLFNDTIRSNIAYGKGGDEASEAEIIAAAELANAHGFISSIQQGYDTV 1117
Query: 3446 VGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCI 3625
VGE+G QLSGGQKQR+AIARA+++ PKILLLDEATSALD ESE+ VQ ALD +RT +
Sbjct: 1118 VGERGIQLSGGQKQRVAIARAIVKEPKILLLDEATSALDAESERVVQDALDRVMVNRTTV 1177
Query: 3626 VVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELI-AKRGAYFALTQKQSSNQS 3778
VVAHRLSTI NA I VVKNG +VE+GTH LI + G Y +L Q S S
Sbjct: 1178 VVAHRLSTIKNADVIAVVKNGVIVEKGTHETLINIEGGVYASLVQLHISASS 1229
>gi|15237456|ref|NP_199466.1| ABC transporter family protein
[Arabidopsis thaliana]
Length = 1248
Score = 817 bits (2110), Expect = 0.0
Identities = 472/1243 (37%), Positives = 697/1243 (55%), Gaps = 7/1243 (0%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
I+ ++L+ + D +++ +G + + A G+ P MSI+MG + F F D +
Sbjct: 18 IAFYKLFTFADRYDIVLMVIGTLSAMANGLTQPFMSILMGQLINVFG-----FSDHDHVF 72
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
E V + +K++YL FLQ SC+MV E+ S R RR + +++R
Sbjct: 73 KE-----------VSKVAVKFLYLAAYAGVVSFLQVSCWMVTGERQSTRIRRLYLKTILR 121
Query: 401 QEIAWYDKNTS-GTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
Q+I ++D T+ G + ++ + +++ G+KVG Q+++ F+GGF VAF LTL
Sbjct: 122 QDIGFFDTETNTGEVIGRMSGDTILIQDSMGEKVGKFTQLVSSFVGGFTVAFIVGMKLTL 181
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
++ P ++ G Y AG + ++ + SIRTV+AF G++ +
Sbjct: 182 ALLPCVPLIVGTGGAMTYIMSKKAQRVQLAYTEAGNVVQQAVGSIRTVVAFTGEKQSMGK 241
Query: 758 YEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFF 937
YE LE K+ +K+ G G+ V++Y +Y A W G + G V+ V
Sbjct: 242 YEKKLEIAYKSMVKQGLYSGLGIGIMMVVVYCTYGFAIWYGARQIIEKGYTGGQVMNVIT 301
Query: 938 SVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNK 1117
S++ G MALGQ + AA ++E I R P+IDAY G+ +I G I +
Sbjct: 302 SILTGGMALGQTLPSLNSFAAGTAAAYKMFETIKRKPKIDAYDMSGEVLEEIKGDIELRD 361
Query: 1118 VEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDI 1297
V F YP R DV+I G SL G TVALVG SG GKST+I L++RFY+P++G++LID I
Sbjct: 362 VYFRYPARPDVQIFVGFSLTVPNGMTVALVGQSGSGKSTVISLIERFYDPESGEVLIDGI 421
Query: 1298 PIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTF 1477
++ F +K++R +G+VSQEP LF T+I +NI YG+ D SD++I ALK ANA++FI
Sbjct: 422 DLKKFQVKWIRSKIGLVSQEPILFATTIRENIVYGKKDASDQEIRTALKLANASNFIDKL 481
Query: 1478 PEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENA 1657
P+GL T+VG+ G Q+SGGQKQRIAIARA+++NPKILLLDEATSALDAESE IVQ AL
Sbjct: 482 PQGLETMVGEHGTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAESERIVQDALVKL 541
Query: 1658 SRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLI-EQKGLYHELVHAQVFAD-- 1828
RTT+V+AHRL+T+R AD I V++ G+V+E GTH+ +I + +G Y +LV Q +
Sbjct: 542 MLSRTTVVVAHRLTTIRTADMIAVVQQGKVIEKGTHDEMIKDPEGTYSQLVRLQEGSKKE 601
Query: 1829 --VDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXX 2002
+D +P+K E + ++S + ++ T S
Sbjct: 602 EAIDKEPEK--CEMSLEIESSDSQNGIHSGTLTSPSGLPGVISLDQTEEFHENISSTKTQ 659
Query: 2003 XXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQM 2182
+ +L ++ +PE +I G V P L S+ I +F P +++
Sbjct: 660 TVKKGKEVSLRRLAHLNKPEISVLLLGSLAAVIHGIVFPVQGLLLSRTIRIFFEPS-NKL 718
Query: 2183 KKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPK 2362
K D FWAL+F+ L + Q LF +A +L RIRS + VL QD ++FD K
Sbjct: 719 KNDSLFWALIFVALGLTDLIVIPLQNYLFAIAGAKLIKRIRSLSFDRVLHQDISWFDDTK 778
Query: 2363 HSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFM 2542
+S G I RL+TDA +KS + LG I +A++ G IAF W +A + + + P M
Sbjct: 779 NSSGVIGARLSTDASTVKSIVGDVLGLIMQNMATIIGAFIIAFTANWLLALMALLVAPVM 838
Query: 2543 AVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPH 2722
+K+ G + E A + A +A+ +IRTV + + K+ +++ D P
Sbjct: 839 FFQGYYQIKFITGFGAKARGKYEEASQVASDAVSSIRTVASFCAEDKVMDLYQEKCDEPK 898
Query: 2723 GGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFG 2902
++ GL YG + + + F G +LI ++ +V FA++ +
Sbjct: 899 QQGFKLGLVSGLCYGGSYLALYVIESVCFLGGSWLIQNRRATF--GEFFQVFFALTLTAV 956
Query: 2903 TIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGT-YPQLSGEVKLNKVFFRYPE 3079
+ ++ P+ KA +A IF++L+ +P+ID + GT P + G+++L V FRYP
Sbjct: 957 GVTQTSTMAPDINKAKDSAASIFDILDSKPKIDSSSEKGTILPIVHGDIELQHVSFRYPM 1016
Query: 3080 RPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNP 3259
RP + I L + + GQT+ALVG SG GKSTVISLLER YDP G + +D +++ +
Sbjct: 1017 RPDIQIFSDLCLTISSGQTVALVGESGSGKSTVISLLERFYDPDSGKILLDQVEIQSLKL 1076
Query: 3260 KHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYE 3439
LR+ + LVSQEP+LF+ +I NI YG + G T E+I TA AN+H FI LP GYE
Sbjct: 1077 SWLREQMGLVSQEPVLFNETIGSNIAYG-KIGGATEEEIITAAKAANVHNFISSLPQGYE 1135
Query: 3440 TRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRT 3619
T VGE+G QLSGGQKQRIAIARA++++PKILLLDEATSALD ESE+ VQ ALD +RT
Sbjct: 1136 TSVGERGVQLSGGQKQRIAIARAILKDPKILLLDEATSALDAESERVVQDALDQVMVNRT 1195
Query: 3620 CIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFA 3748
+VVAH L+TI +A I VVKNG + E G H L+ G +A
Sbjct: 1196 TVVVAHLLTTIKDADMIAVVKNGVIAESGRHETLMEISGGAYA 1238
>gi|25455873|pir||T52319 P-glycoprotein-like protein pgp3 [imported] -
Arabidopsis thaliana
gi|2739309|emb|CAA75922.1| P-glycoprotein-like protein [Arabidopsis
thaliana]
Length = 1229
Score = 816 bits (2108), Expect = 0.0
Identities = 472/1252 (37%), Positives = 707/1252 (55%), Gaps = 6/1252 (0%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+ ++L+ ++ + D L++ VG I + GVG PLM+++ G++ +
Sbjct: 8 VPFYKLFSFSDSTDVLLMIVGSIGAIGNGVGFPLMTLLFGDLIDSI----------GQNQ 57
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
S K + V + CLK+VYLG G A FL+ +C+M+ E+ + R R + +++R
Sbjct: 58 SNK-----DIVEIVSKVCLKFVYLGLGTLGAAFLEVACWMITGERQAARIRSLYLKTILR 112
Query: 401 QEIAWYDKNTS-GTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
Q+I ++D TS G + ++ + + E G+KVG Q++A F+GGF +AF WLLTL
Sbjct: 113 QDIGFFDVETSTGEVVGRMSGDTVLILEAMGEKVGKFIQLIATFVGGFVLAFVKGWLLTL 172
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
+M+ P + I G YA A + E+ L SIRTV +F G++ K
Sbjct: 173 VMLVSIPLLAIAGAAMPIIVTRASSREQAAYAKASTVVEQTLGSIRTVASFTGEKQAMKS 232
Query: 758 YEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFF 937
Y + + + +K+ F +G GL F + + SY LA W G + G V+ V
Sbjct: 233 YREFINLAYRASVKQGFSMGLGLGVVFFVFFCSYALAIWFGGEMILKKGYTGGEVVNVMV 292
Query: 938 SVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNK 1117
+V+ SM+LGQ AA ++E I+R P IDA+ G+ I G I +
Sbjct: 293 TVVASSMSLGQTTPCLTAFAAGKAAAYKMFETIERKPSIDAFDLNGKVLEDIRGEIELRD 352
Query: 1118 VEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDI 1297
V F+YP R ++ G SL G T ALVG SG GKS++I L++RFY+P +G +LID +
Sbjct: 353 VCFSYPARPMEEVFGGFSLLIPSGATAALVGESGSGKSSVISLIERFYDPSSGSVLIDGV 412
Query: 1298 PIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTF 1477
+++F +K++R +G+VSQEP LF++SI +NI YG+ + + E+I A K ANAA+FI
Sbjct: 413 NLKEFQLKWIRGKIGLVSQEPVLFSSSIMENIGYGKENATVEEIQAAAKLANAANFIDKL 472
Query: 1478 PEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENA 1657
P GL TLVG+ G Q+SGGQKQRIAIARA++++P+ILLLDEATSALDAESE +VQ AL+
Sbjct: 473 PRGLETLVGEHGTQLSGGQKQRIAIARAILKDPRILLLDEATSALDAESERVVQEALDRV 532
Query: 1658 SRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTH-ETLIEQKGLYHELVHAQVFADVD 1834
RTT+++AHRLSTVRNAD I V+ G+++E G+H E L + +G Y +L+ Q +
Sbjct: 533 MMSRTTVIVAHRLSTVRNADMIAVIHRGKIVEEGSHSELLKDHEGAYAQLIRLQ---KIK 589
Query: 1835 DKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXG 2014
+PK+ E+ + ++ R S N +T+ D
Sbjct: 590 KEPKRLESSNELRDRSINRGSSRNIRTRVHDDDSVSVLGLLGRQENTEISREQSR----- 644
Query: 2015 AVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDG 2194
++ +I +PE + G + P F + F+++I F P D MK+D
Sbjct: 645 --NVSITRIAALNKPETTILILGTLLGAVNGTIFPIFGILFAKVIEAFFKPPHD-MKRDS 701
Query: 2195 HFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPG 2374
FW+++F++L LF VA RL RIR + V+ + +FD P++S G
Sbjct: 702 RFWSMIFVLLGVASLIVYPMHTYLFAVAGGRLIQRIRVMCFEKVVHMEVGWFDDPENSSG 761
Query: 2375 RITTRLATDAPNIKSAIDYRLG-SIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVG 2551
I +RL+ DA IK+ + L S+ NA A+V GL IAF W++A +++ + P + +
Sbjct: 762 TIGSRLSADAALIKTLVGDSLSLSVKNAAAAV-SGLIIAFTASWKLAVIILVMIPLIGIN 820
Query: 2552 QALMMKYHGGSATSDAK-EMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGG 2728
L +K+ G T+DAK + E A + A +A+ +IRTV + + K+ ++ +
Sbjct: 821 GYLQIKFIKG-FTADAKAKYEEASQVANDAVGSIRTVASFCAEEKVMEMYKKRCEDTIKS 879
Query: 2729 NISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTI 2908
I + +I G+ +G + + + YA+ F G L+ K +V +V A++ + I
Sbjct: 880 GIKQGLISGVGFGISFFVLYSVYASCFYVGARLV--KAGRTNFNDVFQVFLALTMTAIGI 937
Query: 2909 GFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSG-TYPQLSGEVKLNKVFFRYPERP 3085
A+S+ P+ KA AA IF +++ + ID SG + G+++L + F Y RP
Sbjct: 938 SQASSFAPDSSKAKGAAASIFGIIDGKSMIDSRDESGLVLENVKGDIELCHISFTYQTRP 997
Query: 3086 AVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKH 3265
V I + L ++ GQT+ALVG SG GKSTVISLL+R YDP G +T+D +L+++ K
Sbjct: 998 DVQIFRDLCFAIRAGQTVALVGESGSGKSTVISLLQRFYDPDSGHITLDRVELKKLQLKW 1057
Query: 3266 LRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETR 3445
+R+ + LV QEP+LF+ +IR NI YG E + +I A AN H FI + GY+T
Sbjct: 1058 VRQQMGLVGQEPVLFNDTIRSNIAYGKGGDEASEAEIIAAAELANAHGFISSIQQGYDTV 1117
Query: 3446 VGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCI 3625
VGE+G QLSGGQKQR+AIARA+++ PKILLLDEATSALD ESE+ VQ ALD +RT +
Sbjct: 1118 VGERGIQLSGGQKQRVAIARAIVKEPKILLLDEATSALDAESERVVQDALDRVMVNRTTV 1177
Query: 3626 VVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELI-AKRGAYFALTQKQSSNQS 3778
VVAHRLSTI NA I VVKNG +VE+GTH LI + G Y +L Q S S
Sbjct: 1178 VVAHRLSTIKNADVIAVVKNGVIVEKGTHETLINIEGGVYASLVQLHISASS 1229
>gi|17567271|ref|NP_510129.1| P-GlycoProtein related (pgp-15)
[Caenorhabditis elegans]
gi|7499666|pir||T21269 hypothetical protein F22E10.4 - Caenorhabditis
elegans
gi|3876294|emb|CAA91802.1| Hypothetical protein F22E10.4
[Caenorhabditis elegans]
Length = 1270
Score = 816 bits (2107), Expect = 0.0
Identities = 484/1269 (38%), Positives = 690/1269 (54%), Gaps = 28/1269 (2%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+SIF L+RY D +L +G+I + +GV P+++II G V+ +
Sbjct: 82 VSIFGLFRYAKAFDHFLLFIGVICAIISGVSQPVLTIIAGRVTNAILVY----------- 130
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAA--GFLQASCFMVICEKLSNRFRRQFFHSV 394
A +F ++ +N Y++LG GIF ++Q CF C ++ + R ++ +SV
Sbjct: 131 ---APQTKQFRNKATENV--YIFLGIGIFVTITNYIQYMCFQHCCSRIMAQMRHRYVYSV 185
Query: 395 MRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLT 574
+RQ W+DK+ SGT++ KL D++ER+REG GDK+G+ + +A + VA+ Y+W L
Sbjct: 186 LRQNAGWFDKHHSGTIATKLNDSMERIREGIGDKLGVLLRGVAMLVASVVVAYIYEWRLA 245
Query: 575 LIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECK 754
+++ ++P + C AG IAEE L +RTV AFNGQE +
Sbjct: 246 CMLLGVAPTCIGCMSLMARQMTATTVKELGGVEKAGSIAEESLMGVRTVQAFNGQEEMVE 305
Query: 755 RYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLES-GTVLTV 931
RY L G+K I K F G FF ++A F G + G ++S G V +
Sbjct: 306 RYRVELNKGRKFAIWKGFWSGLFGGMFFFWLFAFQGCGFLYGAYLLSVGIIKSPGDVFII 365
Query: 932 FFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISV 1111
++++GS G + A AA S+YE IDR+P+ID YS +G+ K+ GR+
Sbjct: 366 VMAMLLGSYFTGLISPHLMVLLNARVAAGSIYETIDRVPKIDPYSKKGKFLDKVIGRVKF 425
Query: 1112 NKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILID 1291
V F YPTR D KIL G++L +PG +VALVG SGCGKST + LL R Y P+AG + ID
Sbjct: 426 ENVHFRYPTRKDAKILNGLNLTIEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTID 485
Query: 1292 DIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIK 1471
+ + NI YLR ++G+V QEP LFN +I N+ G + + E + K ANA DFI+
Sbjct: 486 GTDVRELNIDYLRNVIGIVQQEPILFNDTIHNNLLLGNPNATREKMIEVCKMANAHDFIE 545
Query: 1472 TFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALE 1651
P+G +T++GD GVQ+SGGQKQR+AIAR LVR PK+LLLDEATSALDA+SESIVQSAL
Sbjct: 546 KMPKGYDTMIGDGGVQLSGGQKQRVAIARTLVREPKVLLLDEATSALDAQSESIVQSALN 605
Query: 1652 NASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFA-- 1825
NAS+GRTTI+IAHRLST+R ADKI+ + G ++E G HE L+ G Y++LV AQ F
Sbjct: 606 NASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYYDLVKAQAFKPD 665
Query: 1826 ------DVDDK-PKKKEAERRMSRQT-------SQRKGSVNFKTQESQVDXXX---XXXX 1954
+++D+ + A SRQ+ S+ G+ F+ D
Sbjct: 666 NDGTVDEIEDEIDLGQSASGLHSRQSSFTSSIRSKMSGAEAFRRGTLGADSFAGGKSTAR 725
Query: 1955 XXXXXXXXXXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLF 2134
G + A I + A+ + LI+G + AF+L
Sbjct: 726 ADAENAAFAEEVAKVMEQDGQISAGYMDIFKNAKGNYTVMFLGFVTGLIRGLELTAFALL 785
Query: 2135 FSQIINVFS--NPDRDQMKKDGHFWALMFLVLAAVQG----TSMLFQCSLFGVAAERLTM 2296
+ F N D +M H A M ++ G S F + +E L +
Sbjct: 786 LGWVFEGFQYLNIDNGKMM---HRMA-MAVIAYGCSGFGCFISQFLSSIFFAIVSENLAL 841
Query: 2297 RIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGG 2476
R R +RN+L QDA++FD P H+PG++ TRLATDAPN K+ +D R+ + A++++
Sbjct: 842 RFRVMSFRNLLYQDASFFDNPAHAPGKLITRLATDAPNCKTVVDSRMLQVLYALSAIIAN 901
Query: 2477 LGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRT 2656
+ I+F Y H G+ T
Sbjct: 902 IVISFIY------------------------CHSGNCTH--------------------- 916
Query: 2657 VQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFD 2836
T+ YN + K +I + Y S ++ F G+ LI+
Sbjct: 917 -----YFTRFYN---------KRSELKKGLIEAINYTITQSFMYYMMCFCFALGIRLIYH 962
Query: 2837 KNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSS 3016
N P++V + A+ + + AA YFPE++KA AAGL+FN++ +PR G
Sbjct: 963 GN--KSPQDVFQGNIAMLLTAMGVMNAAQYFPEFVKAKTAAGLLFNIIYRKPR-TGDLLE 1019
Query: 3017 GTYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLER 3196
G+ P++ G + V F YP+RP PI++GL GQT+ALVGPSG GKST I +LER
Sbjct: 1020 GSRPEVRGNILFENVKFSYPQRPHQPIMKGLQWTALRGQTVALVGPSGSGKSTCIGMLER 1079
Query: 3197 LYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQI 3376
YD G + +D D+R ++ HLR +ALV QEP LF +I+ENI GL+ E+I
Sbjct: 1080 FYDVTGGTLRIDGQDIRGLSLFHLRTQMALVGQEPRLFAGTIKENICLGLE--NVPMEKI 1137
Query: 3377 ETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSA 3556
A AN ++F+ LP G ET VGEKG++LSGGQKQRIAIARAL+R+PKILLLDEATSA
Sbjct: 1138 NHALELANANRFLANLPAGIETDVGEKGSKLSGGQKQRIAIARALVRDPKILLLDEATSA 1197
Query: 3557 LDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRG 3736
LD+ESE+ VQ ALD A + RTCI +AHRLS+I N+ I+ ++NG+V E G H +L++K+G
Sbjct: 1198 LDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDVIVYIENGRVQEAGNHKQLMSKKG 1257
Query: 3737 AYFALTQKQ 3763
Y+ L QKQ
Sbjct: 1258 KYYELIQKQ 1266
Score = 336 bits (861), Expect = 3e-90
Identities = 202/584 (34%), Positives = 310/584 (52%), Gaps = 4/584 (0%)
Frame = +2
Query: 2027 NLFKILRYARP-EWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFS--NPDRDQMKKDGH 2197
++F + RYA+ + +I G P ++ ++ N P Q +
Sbjct: 83 SIFGLFRYAKAFDHFLLFIGVICAIISGVSQPVLTIIAGRVTNAILVYAPQTKQFRNKAT 142
Query: 2198 FWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGR 2377
+FL + + Q F R+ ++R + +VLRQ+A +FD KH G
Sbjct: 143 ENVYIFLGIGIFVTITNYIQYMCFQHCCSRIMAQMRHRYVYSVLRQNAGWFD--KHHSGT 200
Query: 2378 ITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQA 2557
I T+L I+ I +LG + +A + + +A+ Y W++A +++ + P +
Sbjct: 201 IATKLNDSMERIREGIGDKLGVLLRGVAMLVASVVVAYIYEWRLACMLLGVAPTCIGCMS 260
Query: 2558 LMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNIS 2737
LM + + + +E AG A E++ +RTVQA Q ++ + L+ I
Sbjct: 261 LMARQMTATTVKELGGVEKAGSIAEESLMGVRTVQAFNGQEEMVERYRVELNKGRKFAIW 320
Query: 2738 KAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFA 2917
K GL G F F +G +L+ ++ P +V ++ A+ G
Sbjct: 321 KGFWSGLFGGMFFFWLFAFQGCGFLYGAYLL-SVGIIKSPGDVFIIVMAMLLGSYFTGLI 379
Query: 2918 ASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTY-PQLSGEVKLNKVFFRYPERPAVP 3094
+ + + A AAG I+ ++ P+ID + G + ++ G VK V FRYP R
Sbjct: 380 SPHLMVLLNARVAAGSIYETIDRVPKIDPYSKKGKFLDKVIGRVKFENVHFRYPTRKDAK 439
Query: 3095 ILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRK 3274
IL GLN+ ++PG ++ALVG SGCGKST + LL RLY+P G VT+D D+R++N +LR
Sbjct: 440 ILNGLNLTIEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIDYLRN 499
Query: 3275 HIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGE 3454
I +V QEPILF+ +I N++ G P T E++ C AN H FI+++P GY+T +G+
Sbjct: 500 VIGIVQQEPILFNDTIHNNLLLG-NPNA-TREKMIEVCKMANAHDFIEKMPKGYDTMIGD 557
Query: 3455 KGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVA 3634
G QLSGGQKQR+AIAR L+R PK+LLLDEATSALD +SE VQ AL+ A+K RT I++A
Sbjct: 558 GGVQLSGGQKQRVAIARTLVREPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIA 617
Query: 3635 HRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQS 3766
HRLSTI A I+ + G +VE G H EL+ G Y+ L + Q+
Sbjct: 618 HRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYYDLVKAQA 661
>gi|2673951|gb|AAB88657.1| multidrug resistance protein 1 [Aspergillus
fumigatus]
gi|2673953|gb|AAB88658.1| multidrug resistance protein 1 [Aspergillus
fumigatus]
Length = 1349
Score = 815 bits (2106), Expect = 0.0
Identities = 468/1270 (36%), Positives = 699/1270 (54%), Gaps = 28/1270 (2%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNF--VTLGTIFLDPNS 214
+S F LYRY S D L++ V I + A G LPL +I+ G+++ F ++LGT+
Sbjct: 94 VSFFTLYRYASRKDILIILVSAICAIAAGAALPLFTILFGSLASAFQGISLGTM------ 147
Query: 215 TASEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSV 394
EF H++ +N L +VYLG F ++ F+ E L+ + R + ++
Sbjct: 148 -------PYHEFYHKLTKNVLYFVYLGIAEFVTVYVSTVGFIYTGEHLTQKIRENYLEAI 200
Query: 395 MRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLT 574
+RQ +A++DK +G ++ ++ + +++ +KVGL A F+ F VA+ W L
Sbjct: 201 LRQNMAYFDKLGAGEVTTRITADTNLIQDAISEKVGLTLTAFATFVTAFIVAYVKYWKLA 260
Query: 575 LIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECK 754
LI S +++ Y G +AEEV++SIR AF Q+ K
Sbjct: 261 LICTSTIVALVMVMGGGSRFIVKYSKKSIESYGAGGTVAEEVISSIRNATAFGTQDKLAK 320
Query: 755 RYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVF 934
+YE L +K G+K+ ++G + F I++++Y L FW+G+ FV + G VLTV
Sbjct: 321 QYETHLAEAEKWGVKQQVILGMMIGGMFGIMFSNYGLGFWMGSRFVVGKEVNVGQVLTVL 380
Query: 935 FSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVN 1114
S+++GS +LG + AAA +Y IDR +D YS EG+ G I
Sbjct: 381 MSILIGSFSLGNVAPNGQAFTNGVAAAAKIYSTIDRRSPLDPYSDEGKVLDHFEGNIEFR 440
Query: 1115 KVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDD 1294
V+ YP+R +V +++ VSL G+T ALVG SG GKST++ L++RFY P GQ+L+D
Sbjct: 441 NVKHIYPSRPEVTVMEDVSLSMPAGKTTALVGPSGSGKSTVVGLVERFYLPVGGQVLLDG 500
Query: 1295 IPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYG---------RSDVSDEDIARALKE 1447
I+ N+++LRQ + +VSQEP LF+T+I +NI +G D E + A +
Sbjct: 501 HDIQTLNLRWLRQQISLVSQEPVLFSTTIFRNIEHGLIGTKFEHESKDKIRELVENAARM 560
Query: 1448 ANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESE 1627
ANA DFI PEG +T VG RG +SGGQKQRIAIARA+V +PKILLLDEATSALD +SE
Sbjct: 561 ANAHDFIMALPEGYDTNVGQRGFLLSGGQKQRIAIARAIVSDPKILLLDEATSALDTKSE 620
Query: 1628 SIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELV 1807
+VQ+AL+ A+ GRTTIVIAHRLST++ A I+ M G++ E GTH+ L+++KG Y++LV
Sbjct: 621 GVVQAALDKAAEGRTTIVIAHRLSTIKTAHNIVAMVGGKIAEQGTHDELVDRKGTYYKLV 680
Query: 1808 HAQVFADVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXX 1987
AQ + + + + EA+ M ++G KT S +
Sbjct: 681 EAQRINE-EKEAEALEADADMDADDFGQEGVTRIKTAVSSSNSLDAVDEKARLEMKRTGT 739
Query: 1988 XXXXXXXXGAVKA-------NLFKILRYA----RPEWIYXXXXXXXXLIQGAVMPAFSLF 2134
+ K +L+ ++++ RPE Y + G P +
Sbjct: 740 QKSVSSAVLSKKVPEQFEKYSLWTLVKFIGAFNRPELGYMLIGLTFSFLAGGGQPTQAFL 799
Query: 2135 FSQIINVFSNPDR--DQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRS 2308
+++ I+ S P+ +++ D +FW+LMF V+ Q S+ + F + +ERL R RS
Sbjct: 800 YAKAISTLSLPESMFHKLRHDANFWSLMFFVVGIAQFISLSINGTAFAICSERLIRRARS 859
Query: 2309 KVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIA 2488
+ +R++LRQD ++FD ++S G +T+ L+T+ N+ LG+I ++G + IA
Sbjct: 860 QAFRSILRQDISFFDREENSTGALTSFLSTETKNLSGVSGVTLGTIIMTSTTLGAAMIIA 919
Query: 2489 FYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQAL 2668
GW++A + +++ P + L E + A EA IRTV +L
Sbjct: 920 LAIGWKLALVCISVVPILLACGFLRFYMLAQFQQRSKSAYEGSASYACEATSAIRTVASL 979
Query: 2669 TLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVL 2848
T + ++ ++ L ++ + L Y + ++ FF A F +G L+
Sbjct: 980 TREQDVWGVYHDQLQKQGRKSLISVLRSSLLYASSQALVFFCVALGFWYGGTLLGHHEY- 1038
Query: 2849 MEPENVLRVLFAIS---FSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSG 3019
++ R S F + G S+ P+ KA AA + + +P ID + G
Sbjct: 1039 ----SIFRFFVCFSEILFGAQSAGTVFSFAPDMGKAKNAAAQFKKLFDSKPTIDIWSDEG 1094
Query: 3020 T-YPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLER 3196
+ GE++ V FRYP RP P+L+GLN+ VKPGQ +ALVGPSGCGKST I+LLER
Sbjct: 1095 EKLESMEGEIEFRDVHFRYPTRPEQPVLRGLNLSVKPGQYIALVGPSGCGKSTTIALLER 1154
Query: 3197 LYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQI 3376
YD L G V VD D+ ++N R ++LVSQEP L+ +I+ENI+ G+ + + E +
Sbjct: 1155 FYDALAGGVFVDGKDITKLNVNSYRSFLSLVSQEPTLYQGTIKENILLGVDKDDVSEETL 1214
Query: 3377 ETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSA 3556
C ANI+ F+ LP+G++T VG KG LSGGQKQR+AIARAL+R+PK+LLLDEATSA
Sbjct: 1215 IKVCKDANIYDFVMSLPEGFDTVVGSKGGMLSGGQKQRVAIARALLRDPKVLLLDEATSA 1274
Query: 3557 LDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRG 3736
LD+ESEK VQ ALDAAA+ RT I VAHRLSTI NA I V G++VE GTH+ELI +G
Sbjct: 1275 LDSESEKVVQAALDAAARGRTTIAVAHRLSTIQNADIIYVFDQGKIVESGTHHELIRNKG 1334
Query: 3737 AYFALTQKQS 3766
Y+ L QS
Sbjct: 1335 RYYELVNLQS 1344
Score = 341 bits (875), Expect = 7e-92
Identities = 214/605 (35%), Positives = 316/605 (51%), Gaps = 18/605 (2%)
Frame = +2
Query: 2015 AVKANLFKILRYA-RPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKD 2191
+VK + F + RYA R + + + GA +P F++ F + + F M
Sbjct: 91 SVKVSFFTLYRYASRKDILIILVSAICAIAAGAALPLFTILFGSLASAFQGISLGTMPYH 150
Query: 2192 GHFW-----ALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDM 2356
+ L F+ L + ++ F E LT +IR +LRQ+ YFD
Sbjct: 151 EFYHKLTKNVLYFVYLGIAEFVTVYVSTVGFIYTGEHLTQKIRENYLEAILRQNMAYFD- 209
Query: 2357 PKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFL----VM 2524
K G +TTR+ D I+ AI ++G A A+ +A+ W++A + ++
Sbjct: 210 -KLGAGEVTTRITADTNLIQDAISEKVGLTLTAFATFVTAFIVAYVKYWKLALICTSTIV 268
Query: 2525 AIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCS 2704
A+ M G ++KY S S G A E I +IR A Q KL + +
Sbjct: 269 ALVMVMGGGSRFIVKYSKKSIESYGA----GGTVAEEVISSIRNATAFGTQDKLAKQYET 324
Query: 2705 HLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFA 2884
HL + + +I G+ G I F Y F G + K V + VL VL +
Sbjct: 325 HLAEAEKWGVKQQVILGMMIGGMFGIMFSNYGLGFWMGSRFVVGKEVNVG--QVLTVLMS 382
Query: 2885 ISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSG-TYPQLSGEVKLNKV 3061
I ++G A + AA I++ ++ +D + G G ++ V
Sbjct: 383 ILIGSFSLGNVAPNGQAFTNGVAAAAKIYSTIDRRSPLDPYSDEGKVLDHFEGNIEFRNV 442
Query: 3062 FFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNND 3241
YP RP V +++ +++ + G+T ALVGPSG GKSTV+ L+ER Y P+ G V +D +D
Sbjct: 443 KHIYPSRPEVTVMEDVSLSMPAGKTTALVGPSGSGKSTVVGLVERFYLPVGGQVLLDGHD 502
Query: 3242 LRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQ-------IETACSKAN 3400
++ +N + LR+ I+LVSQEP+LF T+I NI +GL ++ HE +E A AN
Sbjct: 503 IQTLNLRWLRQQISLVSQEPVLFSTTIFRNIEHGLIGTKFEHESKDKIRELVENAARMAN 562
Query: 3401 IHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQ 3580
H FI LP+GY+T VG++G LSGGQKQRIAIARA++ +PKILLLDEATSALDT+SE
Sbjct: 563 AHDFIMALPEGYDTNVGQRGFLLSGGQKQRIAIARAIVSDPKILLLDEATSALDTKSEGV 622
Query: 3581 VQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQK 3760
VQ ALD AA+ RT IV+AHRLSTI A I+ + G++ EQGTH+EL+ ++G Y+ L +
Sbjct: 623 VQAALDKAAEGRTTIVIAHRLSTIKTAHNIVAMVGGKIAEQGTHDELVDRKGTYYKLVEA 682
Query: 3761 QSSNQ 3775
Q N+
Sbjct: 683 QRINE 687
>gi|422286|pir||S30328 multidrug resistance protein 2 - Entamoeba
histolytica
gi|158973|gb|AAA29113.1| P-glycoprotein-2
Length = 1310
Score = 814 bits (2102), Expect = 0.0
Identities = 474/1276 (37%), Positives = 709/1276 (55%), Gaps = 35/1276 (2%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+++ QLYRY + +D ++LAVGI S GV P ++MG++ F T + PN A
Sbjct: 37 VTVRQLYRYANWLDLILLAVGIFGSVGCGVLTPCQMLVMGDMVDTFNTNDLMKAFPNQEA 96
Query: 221 SEKAAARAEFSHEVIQNC--------LKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRR 376
F+HEV + LK V G FL CF V+ E+ R
Sbjct: 97 MYDPKYYIPFNHEVTKTVADTINDLVLKMVCFAIGSGVGSFLMTFCFFVMSERQGINIRM 156
Query: 377 QFFHSVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFT 556
+F +++RQ+ WYD + SG L++++ +++++++G K G+ FQ FI G+A+ F
Sbjct: 157 LYFRALLRQDAGWYDFHESGELTSRIASDVQQIQDGMSQKFGIIFQTTTSFIAGYAIGFA 216
Query: 557 YDWLLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNG 736
DW LTL++MS+SPF+++ AG IAE + ++RTV + G
Sbjct: 217 KDWDLTLVIMSMSPFIVLSMTLLAVFATKFTVLGEESLGNAGAIAEATIGNMRTVHSL-G 275
Query: 737 QEYE-CKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGR--- 904
QE+E C+ Y + + + + K +G GL + I ++ L W + V G+
Sbjct: 276 QEHEFCEMYNEKIRVVDRYNVLKGLTVGLGLGAVMFFIMGAFSLGSWYAS-VVLRGKGGK 334
Query: 905 --LESGTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQ 1078
+ +G V+ VF V++ + L TA +A +Y+ IDRIP+ID ST G+
Sbjct: 335 KNVTAGDVMIVFICVLIATQGLSIIAIPLNIFATAKASAYRIYQTIDRIPDIDCRSTAGE 394
Query: 1079 TPSKISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRF 1258
P++ +G I++ V+F YPTR +IL G+ L+ + GQTVALVG+SGCGKST IQL+QR
Sbjct: 395 CPTECNGNITLEDVQFRYPTRPTKQILGGLDLEIKKGQTVALVGASGCGKSTTIQLVQRN 454
Query: 1259 YNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSD---VSDEDI 1429
Y+P G + +D + D NIK+LR +G+V QEP LF +I +NI G D ++E++
Sbjct: 455 YDPVGGSVKLDGKDLRDLNIKWLRNQIGLVGQEPILFACTIRENIMLGARDGETPTEEEM 514
Query: 1430 ARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSA 1609
K ANA +FI PEG +T+VG++G +SGGQKQRIAIARAL+R P ILLLDEATSA
Sbjct: 515 IECAKMANAHEFISHLPEGYDTMVGEKGAALSGGQKQRIAIARALIRKPTILLLDEATSA 574
Query: 1610 LDAESESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKG 1789
LD +SE IVQ ALE AS+GRTTIV+AHRL+TVRNA +I V G+++E GTH+ L++ KG
Sbjct: 575 LDTQSEKIVQQALEKASQGRTTIVVAHRLTTVRNASRICVFHQGEIIEQGTHQELMDLKG 634
Query: 1790 LYHELVHAQVFADVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXX 1969
Y+ LV Q + D+ + +++ Q ++ +N Q D
Sbjct: 635 TYYGLVKRQSMEEEVDQETVENDLKKIREQENKEAEEIN---QHKNTDTNEDPDIVQKLE 691
Query: 1970 XXXXXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQII 2149
V + IL R EW + GA+ P F+L +I
Sbjct: 692 NEYNSEMKKLKHSNRFVLLRV--ILDNFRHEWFLSTFGFIGGIGGGAIFPFFTLKIVDLI 749
Query: 2150 ----NVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVY 2317
++ S+ D K ++ +V+ S LF A ++ R+R +Y
Sbjct: 750 MCLLSINSDTLTDDQKDTIKNICIIVVVIGVASFLSFFMYIGLFLSAGFKMIGRVRKDMY 809
Query: 2318 RNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYY 2497
+++ Q+ ++FD ++ G +TTRLA+D ++ R+G++ + I+++G LGIAFYY
Sbjct: 810 HSIMHQNISWFDRKENMVGSLTTRLASDPTTLQGISGERVGNVIHIISTIGFALGIAFYY 869
Query: 2498 GWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQ 2677
W+++ VMA+ P + V + K + A E +G T +EA+E++RTVQ+LT +
Sbjct: 870 DWKVSLAVMAVSPVLIVVVFINGKLNSLEACPAQAAYEKSGITLVEAVESVRTVQSLTRE 929
Query: 2678 TKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEP 2857
Y +F L P G A + + + F G +LI K+ P
Sbjct: 930 EHFYEVFKDALREPKIGIYKWAPLLSIFMCLTTLLTQVMNPYGFYIGTYLIKKKSNYDLP 989
Query: 2858 ------------ENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRID 3001
E + + + A+ F+ +G + P+ KA AA +++++ +P ID
Sbjct: 990 VPDFMIEFSDRFEEMQKAIMAVIFAAQAVGNLGNIVPDIGKAVRAAKNTYDVIDRKPTID 1049
Query: 3002 GMTSSG-TYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTV 3178
+ G T+ + GE++ + FRYP RP +L+G++ V+ G+T+ALVG SGCGKST
Sbjct: 1050 CYSEEGETFNDVKGEIEFKDICFRYPTRPDNSVLKGISFKVEQGKTVALVGASGCGKSTS 1109
Query: 3179 ISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPG- 3355
+ L+ER YDP G V +D ++++ +N LR I +V QEP+LF S+ +NI G+ G
Sbjct: 1110 VQLIERFYDPTHGDVLLDGHNIKDLNIHFLRSQIGMVGQEPVLFAESVMDNIRRGVPKGV 1169
Query: 3356 EYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILL 3535
E ++EQI A AN H FI +P+GY T VG++G Q+SGGQKQRIAIARALIRNPK+LL
Sbjct: 1170 EVSNEQIYAAAKMANAHDFISAMPEGYNTMVGDRGAQISGGQKQRIAIARALIRNPKVLL 1229
Query: 3536 LDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHN 3715
LDEATSALD+ESEK VQ ALD AAK RT IV+AHRLSTI NA I V+ G++ E+GTH
Sbjct: 1230 LDEATSALDSESEKIVQDALDKAAKGRTTIVIAHRLSTIQNADQICVIMRGRIAERGTHQ 1289
Query: 3716 ELIAKRGAYFALTQKQ 3763
EL+ +G Y+ L +Q
Sbjct: 1290 ELLDLKGFYYTLAMQQ 1305
Score = 389 bits (998), Expect = e-106
Identities = 222/548 (40%), Positives = 323/548 (58%), Gaps = 22/548 (4%)
Frame = +2
Query: 257 EVIQN-CLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYDK--N 427
+ I+N C+ V +G F + F+ F+ K+ R R+ +HS+M Q I+W+D+ N
Sbjct: 766 DTIKNICIIVVVIGVASFLSFFMYIGLFLSAGFKMIGRVRKDMYHSIMHQNISWFDRKEN 825
Query: 428 TSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMM 607
G+L+ +L + ++ +G++VG +++ +AF YDW ++L +M++SP ++
Sbjct: 826 MVGSLTTRLASDPTTLQGISGERVGNVIHIISTIGFALGIAFYYDWKVSLAVMAVSPVLI 885
Query: 608 ICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKK 787
+ Y +G E + S+RTV + +E+ + ++DAL K
Sbjct: 886 VVVFINGKLNSLEACPAQAAYEKSGITLVEAVESVRTVQSLTREEHFYEVFKDALREPKI 945
Query: 788 TGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFV----------------YSGRLESGT 919
K + L+ + ++ F++GT + +S R E
Sbjct: 946 GIYKWAPLLSIFMCLTTLLTQVMNPYGFYIGTYLIKKKSNYDLPVPDFMIEFSDRFEE-- 1003
Query: 920 VLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISG 1099
+ +V+ + A+G G IG A+ AA + Y+VIDR P ID YS EG+T + + G
Sbjct: 1004 MQKAIMAVIFAAQAVGNLGNIVPDIGKAVRAAKNTYDVIDRKPTIDCYSEEGETFNDVKG 1063
Query: 1100 RISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQ 1279
I + F YPTR D +LKG+S + G+TVALVG+SGCGKST +QL++RFY+P G
Sbjct: 1064 EIEFKDICFRYPTRPDNSVLKGISFKVEQGKTVALVGASGCGKSTSVQLIERFYDPTHGD 1123
Query: 1280 ILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRS---DVSDEDIARALKEA 1450
+L+D I+D NI +LR +G+V QEP LF S+ NIR G +VS+E I A K A
Sbjct: 1124 VLLDGHNIKDLNIHFLRSQIGMVGQEPVLFAESVMDNIRRGVPKGVEVSNEQIYAAAKMA 1183
Query: 1451 NAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESES 1630
NA DFI PEG NT+VGDRG Q+SGGQKQRIAIARAL+RNPK+LLLDEATSALD+ESE
Sbjct: 1184 NAHDFISAMPEGYNTMVGDRGAQISGGQKQRIAIARALIRNPKVLLLDEATSALDSESEK 1243
Query: 1631 IVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVH 1810
IVQ AL+ A++GRTTIVIAHRLST++NAD+I V+ G++ E GTH+ L++ KG Y+ L
Sbjct: 1244 IVQDALDKAAKGRTTIVIAHRLSTIQNADQICVIMRGRIAERGTHQELLDLKGFYYTLA- 1302
Query: 1811 AQVFADVD 1834
Q F VD
Sbjct: 1303 MQQFGTVD 1310
Score = 356 bits (913), Expect = 3e-96
Identities = 216/535 (40%), Positives = 299/535 (55%), Gaps = 12/535 (2%)
Frame = +2
Query: 2207 LMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITT 2386
L + A G F V +ER + IR +R +LRQDA ++D H G +T+
Sbjct: 123 LKMVCFAIGSGVGSFLMTFCFFVMSERQGINIRMLYFRALLRQDAGWYDF--HESGELTS 180
Query: 2387 RLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMM 2566
R+A+D I+ + + G IF S G I F W + ++M++ PF+ + L+
Sbjct: 181 RIASDVQQIQDGMSQKFGIIFQTTTSFIAGYAIGFAKDWDLTLVIMSMSPFIVLSMTLLA 240
Query: 2567 KYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAI 2746
+ + + NAG A I N+RTV +L + + ++ + N+
Sbjct: 241 VFATKFTVLGEESLGNAGAIAEATIGNMRTVHSLGQEHEFCEMYNEKIRVVDRYNV---- 296
Query: 2747 IRGLTYGFANSIQFFTYAAAFRFGLFLIF--------DKNVLMEPENVLRVLFAISFSFG 2902
++GLT G F AF G + KNV ++ + I+
Sbjct: 297 LKGLTVGLGLGAVMFFIMGAFSLGSWYASVVLRGKGGKKNVTAGDVMIVFICVLIA---- 352
Query: 2903 TIGFAASYFPEYIKATFAAGL--IFNMLEEEPRIDGMTSSGTYP-QLSGEVKLNKVFFRY 3073
T G + P I AT A I+ ++ P ID +++G P + +G + L V FRY
Sbjct: 353 TQGLSIIAIPLNIFATAKASAYRIYQTIDRIPDIDCRSTAGECPTECNGNITLEDVQFRY 412
Query: 3074 PERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQM 3253
P RP IL GL++ +K GQT+ALVG SGCGKST I L++R YDP+ G+V +D DLR +
Sbjct: 413 PTRPTKQILGGLDLEIKKGQTVALVGASGCGKSTTIQLVQRNYDPVGGSVKLDGKDLRDL 472
Query: 3254 NPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSK-ANIHKFIDELPD 3430
N K LR I LV QEPILF +IRENI+ G + GE E+ C+K AN H+FI LP+
Sbjct: 473 NIKWLRNQIGLVGQEPILFACTIRENIMLGARDGETPTEEEMIECAKMANAHEFISHLPE 532
Query: 3431 GYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAK 3610
GY+T VGEKG LSGGQKQRIAIARALIR P ILLLDEATSALDT+SEK VQ AL+ A++
Sbjct: 533 GYDTMVGEKGAALSGGQKQRIAIARALIRKPTILLLDEATSALDTQSEKIVQQALEKASQ 592
Query: 3611 DRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSSNQ 3775
RT IVVAHRL+T+ NA I V G+++EQGTH EL+ +G Y+ L ++QS +
Sbjct: 593 GRTTIVVAHRLTTVRNASRICVFHQGEIIEQGTHQELMDLKGTYYGLVKRQSMEE 647
>gi|15147363|gb|AAG01549.3| multidrug resistance protein MDR
[Trichophyton rubrum]
Length = 1331
Score = 813 bits (2101), Expect = 0.0
Identities = 469/1261 (37%), Positives = 704/1261 (55%), Gaps = 24/1261 (1%)
Frame = +2
Query: 56 LYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNF--VTLGTIFLDPNSTASEK 229
L+RY + D + LA+ + S A G LPL +++ G+++ F + L I D
Sbjct: 84 LFRYATRNDMIFLAIVSLASIAAGAALPLFTVLFGSLAGTFRDIALHRITYD-------- 135
Query: 230 AAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEI 409
EF+ + +N L +VYLG F ++ F+ + E ++ + R ++ H+++RQ I
Sbjct: 136 -----EFNSILTRNSLYFVYLGIAQFILLYVSTVGFIYVGEHITQKIRAKYLHAILRQNI 190
Query: 410 AWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMS 589
++DK +G ++ ++ + +++G +KVGL ++ F F + + W L LI S
Sbjct: 191 GFFDKLGAGEVTTRITADTNLIQDGISEKVGLTLTALSTFFSAFIIGYVRYWKLALICSS 250
Query: 590 LSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDA 769
M++ Y G +AEEV++SIR AF QE ++YE
Sbjct: 251 TIVAMILVMGGISRFVVKSGRMTLVSYGEGGTVAEEVISSIRNATAFGTQEKLARQYEVH 310
Query: 770 LEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMM 949
L+ +K G + ++G S I+Y++Y L FW+G+ F+ G + ++ + ++++
Sbjct: 311 LKEARKWGRRLQMMLGIMFGSMMAIMYSNYGLGFWMGSRFLVGGETDLSAIVNILLAIVI 370
Query: 950 GSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFT 1129
GS ++G +A+ A A ++ IDR+ ID S EG T + G I ++
Sbjct: 371 GSFSIGNVAPNTQAFASAISAGAKIFSTIDRVSAIDPGSDEGDTIENVEGTIEFRGIKHI 430
Query: 1130 YPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIED 1309
YP+R +V +++ ++L G+T ALVG SG GKST++ LL+RFYNP +G +L+D I+
Sbjct: 431 YPSRPEVVVMEDINLVVPKGKTTALVGPSGSGKSTVVGLLERFYNPVSGSVLLDGRDIKT 490
Query: 1310 FNIKYLRQLVGVVSQEPNLFNTSIEQNIRYG---------RSDVSDEDIARALKEANAAD 1462
N+++LRQ + +VSQEP LF T+I +NIR G + E I A KEANA D
Sbjct: 491 LNLRWLRQQISLVSQEPTLFGTTIFENIRLGLIGSPMENESEEQIKERIVSAAKEANAHD 550
Query: 1463 FIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQS 1642
FI P+G T VG RG +SGGQKQRIAIARA+V +PKILLLDEATSALD +SE +VQ+
Sbjct: 551 FIMGLPDGYATDVGQRGFLLSGGQKQRIAIARAIVSDPKILLLDEATSALDTKSEGVVQA 610
Query: 1643 ALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVF 1822
AL+ ASRGRTTIVIAHRLST+++AD I+V+ G++ E GTH+ L+++KG Y +LV AQ
Sbjct: 611 ALDAASRGRTTIVIAHRLSTIKSADNIVVIVGGRIAEQGTHDELVDKKGTYLQLVEAQKI 670
Query: 1823 ADVDDKPKKKEA----ERRMSRQTSQRKGSVN---FKTQESQVDXXXXXXXXXXXXXXXX 1981
+ + + EA E+ +SRQ S SVN + ++ + +
Sbjct: 671 NEERGEESEDEAVLEKEKEISRQISVPAKSVNSGKYPDEDVEANLGRIDTKKSLSSVILS 730
Query: 1982 XXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFS 2161
++ + I + +PE + ++ GA P S+FF++ I S
Sbjct: 731 QKRSQEKETEYSLGTLIRFIAGFNKPERLIMLCGFFFAVLSGAGQPVQSVFFAKGITTLS 790
Query: 2162 NPDR--DQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQ 2335
P ++++D +FW+LMFL+L VQ + Q +F + +E L R RSK +R +LRQ
Sbjct: 791 LPPSLYGKLREDANFWSLMFLMLGLVQLVTQSAQGVIFAICSESLIYRARSKSFRAMLRQ 850
Query: 2336 DATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAF 2515
D +FD+P++S G +T+ L+T+ ++ LG+I ++ L +A +GW++A
Sbjct: 851 DIAFFDLPENSTGALTSFLSTETKHLSGVSGATLGTILMVSTTLIVALTVALAFGWKLAL 910
Query: 2516 LVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNI 2695
+ ++ P + + T K E++ A EA +IRTV +LT + + I
Sbjct: 911 VCISTVPVLLLCGFYRFWILAQFQTRAKKAYESSASYACEATSSIRTVASLTREQGVMEI 970
Query: 2696 FCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRV 2875
+ L+ ++ L Y + S FF A F +G L+ N +
Sbjct: 971 YEGQLNDQAKKSLRSVAKSSLLYAASQSFSFFCLALGFWYGGGLLGKGEY-----NAFQF 1025
Query: 2876 LFAIS---FSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGE 3043
IS F + G S+ P+ KA AA + + P ID ++ G + + G
Sbjct: 1026 FLCISCVIFGSQSAGIVFSFSPDMGKAKSAAADFKRLFDRVPTIDIESTDGEKLETVEGT 1085
Query: 3044 VKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAV 3223
++ V FRYP RP P+L+GLN+ VKPGQ +ALVGPSGCGKST I+L+ER YD L G V
Sbjct: 1086 IEFRDVHFRYPTRPEQPVLRGLNLTVKPGQYIALVGPSGCGKSTTIALVERFYDTLSGGV 1145
Query: 3224 TVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANI 3403
+D D+ ++N R H+ALVSQEP L+ +IR+N++ G+ + EQ+ AC ANI
Sbjct: 1146 YIDGKDISRLNVNSYRSHLALVSQEPTLYQGTIRDNVLLGVDRDDVPDEQVFAACKAANI 1205
Query: 3404 HKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQV 3583
+ FI LPDG+ T VG KG+ LSGGQKQRIAIARALIR+PK+LLLDEATSALD+ESEK V
Sbjct: 1206 YDFIMSLPDGFGTVVGSKGSMLSGGQKQRIAIARALIRDPKVLLLDEATSALDSESEKVV 1265
Query: 3584 QVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQ 3763
Q ALDAAAK RT I VAHRLSTI A I V G++VE GTH+EL+ +G Y+ L Q
Sbjct: 1266 QAALDAAAKGRTTIAVAHRLSTIQKADIIYVFDQGRIVESGTHHELLQNKGRYYELVHMQ 1325
Query: 3764 S 3766
S
Sbjct: 1326 S 1326
Score = 339 bits (870), Expect = 3e-91
Identities = 218/611 (35%), Positives = 318/611 (51%), Gaps = 15/611 (2%)
Frame = +2
Query: 2021 KANLFKILRYA-RPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGH 2197
KA + RYA R + I+ + GA +P F++ F + F + ++ D
Sbjct: 78 KATYGTLFRYATRNDMIFLAIVSLASIAAGAALPLFTVLFGSLAGTFRDIALHRITYDEF 137
Query: 2198 FW-----ALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPK 2362
+L F+ L Q + F E +T +IR+K +LRQ+ +FD K
Sbjct: 138 NSILTRNSLYFVYLGIAQFILLYVSTVGFIYVGEHITQKIRAKYLHAILRQNIGFFD--K 195
Query: 2363 HSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFM 2542
G +TTR+ D I+ I ++G A+++ I + W++A + + M
Sbjct: 196 LGAGEVTTRITADTNLIQDGISEKVGLTLTALSTFFSAFIIGYVRYWKLALICSSTIVAM 255
Query: 2543 AVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPH 2722
+ + ++ S G A E I +IR A Q KL + HL
Sbjct: 256 ILVMGGISRFVVKSGRMTLVSYGEGGTVAEEVISSIRNATAFGTQEKLARQYEVHLKEAR 315
Query: 2723 GGNISKAIIRGLTYGFANSIQFFTYAAAFRFGL-FLIFDKNVLMEPENVLRVLFAISFSF 2899
++ G+ +G +I + Y F G FL+ + L N+L + SFS
Sbjct: 316 KWGRRLQMMLGIMFGSMMAIMYSNYGLGFWMGSRFLVGGETDLSAIVNILLAIVIGSFSI 375
Query: 2900 GTIGFAASYFPEYIKATFAAGLIFNMLEEEPRID-GMTSSGTYPQLSGEVKLNKVFFRYP 3076
G + A + A A IF+ ++ ID G T + G ++ + YP
Sbjct: 376 GNV---APNTQAFASAISAGAKIFSTIDRVSAIDPGSDEGDTIENVEGTIEFRGIKHIYP 432
Query: 3077 ERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMN 3256
RP V +++ +N+ V G+T ALVGPSG GKSTV+ LLER Y+P+ G+V +D D++ +N
Sbjct: 433 SRPEVVVMEDINLVVPKGKTTALVGPSGSGKSTVVGLLERFYNPVSGSVLLDGRDIKTLN 492
Query: 3257 PKHLRKHIALVSQEPILFDTSIRENIVYGL-------QPGEYTHEQIETACSKANIHKFI 3415
+ LR+ I+LVSQEP LF T+I ENI GL + E E+I +A +AN H FI
Sbjct: 493 LRWLRQQISLVSQEPTLFGTTIFENIRLGLIGSPMENESEEQIKERIVSAAKEANAHDFI 552
Query: 3416 DELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVAL 3595
LPDGY T VG++G LSGGQKQRIAIARA++ +PKILLLDEATSALDT+SE VQ AL
Sbjct: 553 MGLPDGYATDVGQRGFLLSGGQKQRIAIARAIVSDPKILLLDEATSALDTKSEGVVQAAL 612
Query: 3596 DAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSSNQ 3775
DAA++ RT IV+AHRLSTI +A I+V+ G++ EQGTH+EL+ K+G Y L + Q N+
Sbjct: 613 DAASRGRTTIVIAHRLSTIKSADNIVVIVGGRIAEQGTHDELVDKKGTYLQLVEAQKINE 672
Query: 3776 SGGAFDTSEAL 3808
G EA+
Sbjct: 673 ERGEESEDEAV 683
>gi|25297456|pir||F86155 probable ABC transporter [imported] -
Arabidopsis thaliana
gi|9972377|gb|AAG10627.1| Putative ABC transporter [Arabidopsis
thaliana]
Length = 1229
Score = 813 bits (2100), Expect = 0.0
Identities = 461/1239 (37%), Positives = 690/1239 (55%), Gaps = 23/1239 (1%)
Frame = +2
Query: 101 GIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHEVIQNCLK 280
G + + GV LPLM+++ G++ +F K + V + CLK
Sbjct: 4 GSLGAIGNGVCLPLMTLLFGDLIDSF---------------GKNQNNKDIVDVVSKVCLK 48
Query: 281 YVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYDKNTS-GTLSNKLF 457
+VYLG G A FLQ +C+M+ E+ + + R + +++RQ+I ++D T+ G + ++
Sbjct: 49 FVYLGLGRLGAAFLQVACWMITGERQAAKIRSNYLKTILRQDIGFFDVETNTGEVVGRMS 108
Query: 458 DNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXXXXX 637
+ +++ G+KVG Q+++ F+GGFA+AF WLLTL+M++ PF+ + G
Sbjct: 109 GDTVHIQDAMGEKVGKFIQLVSTFVGGFALAFAKGWLLTLVMLTSIPFLAMAGAAMALLV 168
Query: 638 XXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFLIG 817
YA A + E+ + SIRTV +F G++ Y+ + K+ I++ F G
Sbjct: 169 TRASSRGQAAYAKAATVVEQTIGSIRTVASFTGEKQAINSYKKYITSAYKSSIQQGFSTG 228
Query: 818 AGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQFATIG 997
GL + ++SY LA W G + G+V+ V V+ GSM+LGQ
Sbjct: 229 LGLGVMIYVFFSSYALAIWFGGKMILEKGYTGGSVINVIIIVVAGSMSLGQTSPCVTAFA 288
Query: 998 TALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKGVSLD 1177
AA ++E I R P IDAY G+ I G I + V F+YP R D +I G SL
Sbjct: 289 AGQAAAYKMFETIKRKPLIDAYDVNGKVLGDIRGDIELKDVHFSYPARPDEEIFDGFSLF 348
Query: 1178 AQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQE 1357
G T ALVG SG GKST+I L++RFY+P AG++LID I +++F +K++R +G+V QE
Sbjct: 349 IPSGATAALVGESGSGKSTVINLIERFYDPKAGEVLIDGINLKEFQLKWIRSKIGLVCQE 408
Query: 1358 PNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQK 1537
P LF++SI +NI YG+ + + ++I A + ANAA FI P+GL+T VG+ G Q+SGGQK
Sbjct: 409 PVLFSSSIMENIAYGKENATLQEIKVATELANAAKFINNLPQGLDTKVGEHGTQLSGGQK 468
Query: 1538 QRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLSTVRNAD 1717
QRIAIARA++++P++LLLDEATSALD ESE +VQ AL+ RTT+V+AHRLSTVRNAD
Sbjct: 469 QRIAIARAILKDPRVLLLDEATSALDTESERVVQEALDRVMVNRTTVVVAHRLSTVRNAD 528
Query: 1718 KIIVMKAGQVMEVGTHETLIEQK-GLYHELVHAQ-VFADVDDKPKKKEAERRMSRQTSQR 1891
I V+ +G+++E G+H L++ G Y +L+ Q + D KP M+ +S R
Sbjct: 529 MIAVIHSGKMVEKGSHSELLKDSVGAYSQLIRCQEINKGHDAKPSD------MASGSSFR 582
Query: 1892 KGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXGA------------------ 2017
++N + S + G+
Sbjct: 583 NSNLNISREGSVISGGTSSFGNSSRHHSLNVLGLFAGLDLGSGSQRVGQEETGTTSQEPL 642
Query: 2018 VKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGH 2197
K +L +I +PE I GA+ P F + S++I F P DQ+KKD
Sbjct: 643 RKVSLTRIAALNKPEIPVLLLGTVVAAINGAIFPLFGILISRVIEAFFKP-ADQLKKDSR 701
Query: 2198 FWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGR 2377
FWA++F+ L Q LF VA +L RI+S + + + ++FD P++S G
Sbjct: 702 FWAIIFVALGVTSLIVSPSQMYLFAVAGGKLIRRIQSMCFEKAVHMEVSWFDEPENSSGT 761
Query: 2378 ITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQA 2557
+ RL+TDA I++ + L AS GL IAF W++A +++ + P + +
Sbjct: 762 MGARLSTDAALIRALVGDALSLAVQNAASAASGLIIAFTASWELALIILVMLPLIGINGF 821
Query: 2558 LMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNIS 2737
L +K+ G + + E A + A +A+ +IRTV + + K+ ++ + P +
Sbjct: 822 LQVKFMKGFSADAKSKYEEASQVANDAVGSIRTVASFCAEEKVMQMYNKQCEGPIKDGVK 881
Query: 2738 KAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFA 2917
+ I GL +GF+ I F YA +F L+ D +V +V FA++ + I +
Sbjct: 882 QGFISGLGFGFSFFILFCVYATSFYAAARLVEDGKTTF--IDVFQVFFALTMAAIGISQS 939
Query: 2918 ASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGT-YPQLSGEVKLNKVFFRYPERPAVP 3094
+++ P+ KA AA IF +++ + +ID +GT + G+++L + F YP RP +
Sbjct: 940 STFAPDSSKAKVAAASIFAIIDRKSKIDSSDETGTVLENVKGDIELRHLSFTYPARPGIQ 999
Query: 3095 ILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRK 3274
I + L + ++ G+T+ALVG SG GKSTVISLL+R YDP G +T+D +L+++ K LR+
Sbjct: 1000 IFRDLCLTIRAGKTVALVGESGSGKSTVISLLQRFYDPDSGQITLDGVELKKLQLKWLRQ 1059
Query: 3275 HIALVSQEPILFDTSIRENIVYGLQPGE-YTHEQIETACSKANIHKFIDELPDGYETRVG 3451
+ LV QEP+LF+ +IR NI YG E T +I A AN HKFI + GY+T VG
Sbjct: 1060 QMGLVGQEPVLFNDTIRANIAYGKGSEEAATESEIIAAAELANAHKFISSIQQGYDTVVG 1119
Query: 3452 EKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVV 3631
EKG QLSGGQKQR+AIARA+++ PKILLLDEATSALD ESE+ VQ ALD +RT +VV
Sbjct: 1120 EKGIQLSGGQKQRVAIARAIVKEPKILLLDEATSALDAESERLVQDALDRVIVNRTTVVV 1179
Query: 3632 AHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFA 3748
AHRLSTI NA I +VKNG + E GTH LI G +A
Sbjct: 1180 AHRLSTIKNADVIAIVKNGVIAENGTHETLIKIDGGVYA 1218
Score = 372 bits (956), Expect = e-101
Identities = 217/585 (37%), Positives = 320/585 (54%), Gaps = 6/585 (1%)
Frame = +2
Query: 89 MLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHEVIQ 268
+L +G +V+ G PL I++ V + F P + + A
Sbjct: 660 VLLLGTVVAAINGAIFPLFGILISRVIE-------AFFKPADQLKKDSRFWA-------- 704
Query: 269 NCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYDK--NTSGTL 442
+ +V LG Q F V KL R + F + E++W+D+ N+SGT+
Sbjct: 705 --IIFVALGVTSLIVSPSQMYLFAVAGGKLIRRIQSMCFEKAVHMEVSWFDEPENSSGTM 762
Query: 443 SNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLF 622
+L + +R GD + LA Q A G +AFT W L LI++ + P + I G
Sbjct: 763 GARLSTDAALIRALVGDALSLAVQNAASAASGLIIAFTASWELALIILVMLPLIGINGFL 822
Query: 623 XXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKK 802
+Y A +A + + SIRTV +F +E + Y E K G+K+
Sbjct: 823 QVKFMKGFSADAKSKYEEASQVANDAVGSIRTVASFCAEEKVMQMYNKQCEGPIKDGVKQ 882
Query: 803 SFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQ 982
F+ G G F I++ Y +F+ V G+ V VFF++ M ++ + Q+
Sbjct: 883 GFISGLGFGFSFFILFCVYATSFYAAARLVEDGKTTFIDVFQVFFALTMAAIGISQSSTF 942
Query: 983 FATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILK 1162
A AAAS++ +IDR +ID+ G + G I + + FTYP R ++I +
Sbjct: 943 APDSSKAKVAAASIFAIIDRKSKIDSSDETGTVLENVKGDIELRHLSFTYPARPGIQIFR 1002
Query: 1163 GVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVG 1342
+ L + G+TVALVG SG GKST+I LLQRFY+PD+GQI +D + ++ +K+LRQ +G
Sbjct: 1003 DLCLTIRAGKTVALVGESGSGKSTVISLLQRFYDPDSGQITLDGVELKKLQLKWLRQQMG 1062
Query: 1343 VVSQEPNLFNTSIEQNIRYGRSD---VSDEDIARALKEANAADFIKTFPEGLNTLVGDRG 1513
+V QEP LFN +I NI YG+ ++ +I A + ANA FI + +G +T+VG++G
Sbjct: 1063 LVGQEPVLFNDTIRANIAYGKGSEEAATESEIIAAAELANAHKFISSIQQGYDTVVGEKG 1122
Query: 1514 VQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHR 1693
+Q+SGGQKQR+AIARA+V+ PKILLLDEATSALDAESE +VQ AL+ RTT+V+AHR
Sbjct: 1123 IQLSGGQKQRVAIARAIVKEPKILLLDEATSALDAESERLVQDALDRVIVNRTTVVVAHR 1182
Query: 1694 LSTVRNADKIIVMKAGQVMEVGTHETLIE-QKGLYHELVHAQVFA 1825
LST++NAD I ++K G + E GTHETLI+ G+Y LV + A
Sbjct: 1183 LSTIKNADVIAIVKNGVIAENGTHETLIKIDGGVYASLVQLHMTA 1227
Score = 335 bits (858), Expect = 7e-90
Identities = 203/567 (35%), Positives = 315/567 (54%), Gaps = 6/567 (1%)
Frame = +2
Query: 2105 GAVMPAFSLFFSQIINVFSNPDRDQMKKD----GHFWALMFLVLAAVQGTSMLFQCSLFG 2272
G +P +L F +I+ F ++Q KD L F+ L + + Q + +
Sbjct: 12 GVCLPLMTLLFGDLIDSFG---KNQNNKDIVDVVSKVCLKFVYLGLGRLGAAFLQVACWM 68
Query: 2273 VAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFN 2452
+ ER +IRS + +LRQD +FD+ ++ G + R++ D +I+ A+ ++G
Sbjct: 69 ITGERQAAKIRSNYLKTILRQDIGFFDVETNT-GEVVGRMSGDTVHIQDAMGEKVGKFIQ 127
Query: 2453 AIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAM 2632
+++ GG +AF GW + +++ PF+A+ A M +++ A
Sbjct: 128 LVSTFVGGFALAFAKGWLLTLVMLTSIPFLAMAGAAMALLVTRASSRGQAAYAKAATVVE 187
Query: 2633 EAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFR 2812
+ I +IRTV + T + + N + ++ + + +I + GL G + F +YA A
Sbjct: 188 QTIGSIRTVASFTGEKQAINSYKKYITSAYKSSIQQGFSTGLGLGVMIYVFFSSYALAIW 247
Query: 2813 FGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEP 2992
FG +I +K +V+ V+ + ++G + + AA +F ++ +P
Sbjct: 248 FGGKMILEKGYT--GGSVINVIIIVVAGSMSLGQTSPCVTAFAAGQAAAYKMFETIKRKP 305
Query: 2993 RIDGMTSSG-TYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGK 3169
ID +G + G+++L V F YP RP I G ++ + G T ALVG SG GK
Sbjct: 306 LIDAYDVNGKVLGDIRGDIELKDVHFSYPARPDEEIFDGFSLFIPSGATAALVGESGSGK 365
Query: 3170 STVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQ 3349
STVI+L+ER YDP G V +D +L++ K +R I LV QEP+LF +SI ENI YG +
Sbjct: 366 STVINLIERFYDPKAGEVLIDGINLKEFQLKWIRSKIGLVCQEPVLFSSSIMENIAYGKE 425
Query: 3350 PGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKI 3529
T ++I+ A AN KFI+ LP G +T+VGE GTQLSGGQKQRIAIARA++++P++
Sbjct: 426 NA--TLQEIKVATELANAAKFINNLPQGLDTKVGEHGTQLSGGQKQRIAIARAILKDPRV 483
Query: 3530 LLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGT 3709
LLLDEATSALDTESE+ VQ ALD +RT +VVAHRLST+ NA I V+ +G++VE+G+
Sbjct: 484 LLLDEATSALDTESERVVQEALDRVMVNRTTVVVAHRLSTVRNADMIAVIHSGKMVEKGS 543
Query: 3710 HNELIAKR-GAYFALTQKQSSNQSGGA 3787
H+EL+ GAY L + Q N+ A
Sbjct: 544 HSELLKDSVGAYSQLIRCQEINKGHDA 570
>gi|19032275|dbj|BAB85651.1| multidrug resistance protein 1 homolog
[Triticum aestivum]
Length = 1262
Score = 813 bits (2100), Expect = 0.0
Identities = 465/1256 (37%), Positives = 704/1256 (56%), Gaps = 12/1256 (0%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+ + ++RY +D L++ VG + + GV PL+S++ G+V +F ST
Sbjct: 28 VPLLGMFRYADRLDMLLMVVGSLGAVGNGVSEPLISVLFGDVINSF---------GESTT 78
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
S A V + L ++YLG G A FLQ +C+ + E+ S R R + SV+R
Sbjct: 79 STVLRA-------VTKVVLNFIYLGIGTAVASFLQVACWTMAGERQSARIRSLYLKSVLR 131
Query: 401 QEIAWYDKN-TSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
Q+IA++D T+G +++ + +++ G+K G Q+ + F GGF +AFT WLLTL
Sbjct: 132 QDIAFFDTEMTTGEAVSRMSSDTVIIQDALGEKAGKLVQLTSAFFGGFIIAFTKGWLLTL 191
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
+M++ P + I G Y+ A E+ + SIRTV++FNG++ +
Sbjct: 192 VMLTSLPLVAIAGAVSAQMLTRVSSKRLTSYSDAANTVEQTIGSIRTVVSFNGEKKAIEM 251
Query: 758 YEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFF 937
Y ++ +T +++ + G G+ S F I+++SY LAFW G + G ++TV F
Sbjct: 252 YNKFIKSAYRTVVEEGLVNGFGMGSVFCILFSSYGLAFWYGGKLIIDKGYTGGKIVTVLF 311
Query: 938 SVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNK 1117
+V+ G+ +LG A + I AA L+E I+R PEID+ T G I G + +
Sbjct: 312 AVLNGATSLGNATPSISAIAEGQSAAYRLFETIERKPEIDSDDTSGMIMENIKGYVELKD 371
Query: 1118 VEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDI 1297
V F YP R IL G+SL G T+A+VG SG GKST+I L++RFY+P AG++LID +
Sbjct: 372 VYFRYPARLGQLILDGLSLQVASGTTMAIVGESGSGKSTVISLVERFYDPQAGEVLIDGV 431
Query: 1298 PIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTF 1477
I++ N+ ++R +G+VSQEP LF TSI+ NI YG+ D + E+I RA + ANAA+FI
Sbjct: 432 NIKNLNLDWIRGKIGLVSQEPLLFMTSIKDNIIYGKEDATLEEIKRAAELANAANFIDKL 491
Query: 1478 PEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENA 1657
P G +TLVG RG +SGGQKQRIAIARA++++PKILLLDEATSALD ESE IVQ AL
Sbjct: 492 PNGYDTLVGQRGTLLSGGQKQRIAIARAILKDPKILLLDEATSALDVESERIVQEALNRI 551
Query: 1658 SRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLI-EQKGLYHELVHAQVFADVD 1834
RTT+V+AHRLSTVRN D I V+ G+++E GTH L+ + G Y +L+ Q +
Sbjct: 552 MVERTTLVVAHRLSTVRNVDCITVVHQGKIVEQGTHHALVKDPNGAYSQLIRLQETRGDE 611
Query: 1835 DK-------PKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXX 1993
+ P +S + S K S + S +
Sbjct: 612 RRKIQDSGVPNSLSKSTSLSIRRSMTKDSFGNSNRYSFKNPLGLSVELHEDEITGEQNKD 671
Query: 1994 XXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDR 2173
KA + ++ +PE + + G + P F + S +I F P
Sbjct: 672 DLSNGKTLQKAPIGRLFYLNKPEVPFLLLGAIAASVHGVIFPLFGILMSGVIKAFYEPP- 730
Query: 2174 DQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFD 2353
D+++KD FWAL+ +VL ++ + LFG+A +L R+R+ ++N++ Q+ +FD
Sbjct: 731 DKLRKDSSFWALISVVLGFASFIAIPAEYLLFGIAGGKLIERVRTLSFQNIVHQEVAWFD 790
Query: 2354 MPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIF 2533
P +S G + TRL+ DA N++ + LG I + A++ G IAF W++A ++ +
Sbjct: 791 NPSNSSGALGTRLSVDALNVRRLVGDNLGLIVQSTAALITGFVIAFTADWRLALIITCVI 850
Query: 2534 PFMAVGQALMMKYHGGSATSDAKEM-ENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHL 2710
P + +K+ G + +AKEM E+A + A +A+ +IRT+ + + ++ +
Sbjct: 851 PLVGAQGYAQVKFLKG-FSEEAKEMYEDASQVATDAVGSIRTIASFCAEKRVVTTYNKKC 909
Query: 2711 DAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAIS 2890
+A I I+ GL +GF+ + + TYA F G + +V +V FA+
Sbjct: 910 EALRKQGIRSGIVGGLGFGFSFLVLYLTYALCFYVGAQFVRQGKTTF--ADVFKVFFALV 967
Query: 2891 FSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSG-TYPQLSGEVKLNKVFF 3067
+ + A++ KA +A +F++L+ + +ID G ++G++ + V F
Sbjct: 968 LAAVGVSQASALASNATKARDSAISVFSILDRKSKIDTSNDEGLVLENVTGDIHFSNVSF 1027
Query: 3068 RYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLR 3247
+YP RP V I +H+ +T+ALVG SG GKST+I+LLER YDP G ++VD +++
Sbjct: 1028 KYPSRPDVQIFSDFTLHIPSRKTIALVGESGSGKSTIIALLERFYDPDSGIISVDGVEIK 1087
Query: 3248 QMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELP 3427
+ LR + LV QEP+LF+ +IR NI YG + GE T E++ AN H+FI LP
Sbjct: 1088 SLRISWLRDQMGLVGQEPVLFNDTIRANITYG-KHGEVTEEEVTAVAKAANAHEFISSLP 1146
Query: 3428 DGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAA 3607
GY+T VGEKG QLSGGQKQR+AIARA+I++PKILLLDEATSALD ESE+ VQ ALD
Sbjct: 1147 QGYDTLVGEKGVQLSGGQKQRVAIARAIIKDPKILLLDEATSALDAESERIVQDALDRVM 1206
Query: 3608 KDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIA-KRGAYFALTQKQSSN 3772
RT IVVAHRLSTI A I V+K G++ E+G H L+ K G Y +L + +S++
Sbjct: 1207 VSRTTIVVAHRLSTIKGADMIAVLKEGKIAEKGKHEALMGIKDGVYASLVELRSNS 1262
Score = 355 bits (911), Expect = 5e-96
Identities = 218/586 (37%), Positives = 326/586 (55%), Gaps = 3/586 (0%)
Frame = +2
Query: 2021 KANLFKILRYA-RPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGH 2197
K L + RYA R + + + G P S+ F +IN F + +
Sbjct: 27 KVPLLGMFRYADRLDMLLMVVGSLGAVGNGVSEPLISVLFGDVINSFGESTTSTVLRAVT 86
Query: 2198 FWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGR 2377
L F+ L + Q + + +A ER + RIRS ++VLRQD +FD + + G
Sbjct: 87 KVVLNFIYLGIGTAVASFLQVACWTMAGERQSARIRSLYLKSVLRQDIAFFDT-EMTTGE 145
Query: 2378 ITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQA 2557
+R+++D I+ A+ + G + ++ GG IAF GW + +++ P +A+ A
Sbjct: 146 AVSRMSSDTVIIQDALGEKAGKLVQLTSAFFGGFIIAFTKGWLLTLVMLTSLPLVAIAGA 205
Query: 2558 LMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNIS 2737
+ + ++ +A T + I +IRTV + + K ++ + + + +
Sbjct: 206 VSAQMLTRVSSKRLTSYSDAANTVEQTIGSIRTVVSFNGEKKAIEMYNKFIKSAYRTVVE 265
Query: 2738 KAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFA 2917
+ ++ G G I F +Y AF +G LI DK ++ VLFA+ ++G A
Sbjct: 266 EGLVNGFGMGSVFCILFSSYGLAFWYGGKLIIDKGYT--GGKIVTVLFAVLNGATSLGNA 323
Query: 2918 ASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKLNKVFFRYPERPAVP 3094
+ AA +F +E +P ID +SG + + G V+L V+FRYP R
Sbjct: 324 TPSISAIAEGQSAAYRLFETIERKPEIDSDDTSGMIMENIKGYVELKDVYFRYPARLGQL 383
Query: 3095 ILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRK 3274
IL GL++ V G T+A+VG SG GKSTVISL+ER YDP G V +D +++ +N +R
Sbjct: 384 ILDGLSLQVASGTTMAIVGESGSGKSTVISLVERFYDPQAGEVLIDGVNIKNLNLDWIRG 443
Query: 3275 HIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGE 3454
I LVSQEP+LF TSI++NI+YG + + T E+I+ A AN FID+LP+GY+T VG+
Sbjct: 444 KIGLVSQEPLLFMTSIKDNIIYGKE--DATLEEIKRAAELANAANFIDKLPNGYDTLVGQ 501
Query: 3455 KGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVA 3634
+GT LSGGQKQRIAIARA++++PKILLLDEATSALD ESE+ VQ AL+ +RT +VVA
Sbjct: 502 RGTLLSGGQKQRIAIARAILKDPKILLLDEATSALDVESERIVQEALNRIMVERTTLVVA 561
Query: 3635 HRLSTIVNAGCIMVVKNGQVVEQGTHNELIA-KRGAYFALTQKQSS 3769
HRLST+ N CI VV G++VEQGTH+ L+ GAY L + Q +
Sbjct: 562 HRLSTVRNVDCITVVHQGKIVEQGTHHALVKDPNGAYSQLIRLQET 607
>gi|5456701|gb|AAD43626.1| multidrug resistance protein MDR
[Emericella nidulans]
gi|6856159|gb|AAF29805.1| ABC-transporter [Emericella nidulans]
Length = 1348
Score = 811 bits (2096), Expect = 0.0
Identities = 467/1263 (36%), Positives = 700/1263 (54%), Gaps = 21/1263 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNF--VTLGTIFLDPNS 214
IS F L+RY + +D L++ + I + A G LPL +I+ G+++ F + L I D
Sbjct: 100 ISFFGLWRYATKMDILIMVISTICAIAAGAALPLFTILFGSLASTFQRIMLYQISYD--- 156
Query: 215 TASEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSV 394
EF E+ +N L +VYLG G F ++ F+ E + + R + S+
Sbjct: 157 ----------EFYDELTKNVLYFVYLGIGEFVTVYVSTVGFIYTGEHATQKIREYYLESI 206
Query: 395 MRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLT 574
+RQ I ++DK +G ++ ++ + +++G +KVGL +A F+ F +A+ W L
Sbjct: 207 LRQNIGYFDKLGAGEVTTRITADTNLIQDGISEKVGLTLTALATFVTAFIIAYVKYWKLA 266
Query: 575 LIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECK 754
LI S +++ Y G +AEEV++SIR AF Q+ K
Sbjct: 267 LICSSTIVALVLTMGGGSQFIIKYSKKSLDSYGAGGTVAEEVISSIRNATAFGTQDKLAK 326
Query: 755 RYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVF 934
+YE L+ +K G K ++G + + F ++Y++Y L FW+G+ F+ G ++ G +LTV
Sbjct: 327 QYEVHLDEAEKWGTKNQIVMGFMIGAMFGLMYSNYGLGFWMGSRFLVDGAVDVGDILTVL 386
Query: 935 FSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVN 1114
++++GS +LG A+ AAA ++ IDR +D YS EG+T G I +
Sbjct: 387 MAILIGSFSLGNVSPNAQAFTNAVAAAAKIFGTIDRQSPLDPYSNEGKTLDHFEGHIELR 446
Query: 1115 KVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDD 1294
V+ YP+R +V +++ VSL G+T ALVG SG GKST++ L++RFY P G +L+D
Sbjct: 447 NVKHIYPSRPEVTVMEDVSLSMPAGKTTALVGPSGSGKSTVVGLVERFYMPVRGTVLLDG 506
Query: 1295 IPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYG---------RSDVSDEDIARALKE 1447
I+D N+++LRQ + +VSQEP LF T+I +NIR+G D E I A K
Sbjct: 507 HDIKDLNLRWLRQQISLVSQEPVLFGTTIYKNIRHGLIGTKYENESEDKVRELIENAAKM 566
Query: 1448 ANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESE 1627
ANA DFI PEG T VG RG +SGGQKQRIAIARA+V +PKILLLDEATSALD +SE
Sbjct: 567 ANAHDFITALPEGYETNVGQRGFLLSGGQKQRIAIARAVVSDPKILLLDEATSALDTKSE 626
Query: 1628 SIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELV 1807
+VQ+ALE A+ GRTTIVIAHRLST++ A I+V+ G++ E GTH+ L+++ G Y +LV
Sbjct: 627 GVVQAALERAAEGRTTIVIAHRLSTIKTAHNIVVLVNGKIAEQGTHDELVDRGGAYRKLV 686
Query: 1808 HAQVFADVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXX 1987
AQ + + ++A+ K + S +D
Sbjct: 687 EAQRINEQKEADALEDADAEDLTNADIAKIKTA-SSASSDLDGKPTTIDRTGTHKSVSSA 745
Query: 1988 XXXXXXXXGAVKANLFKILRYA----RPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINV 2155
K +L+ +L++ RPE Y ++ G P ++ +++ I+
Sbjct: 746 ILSKRPPETTPKYSLWTLLKFVASFNRPEIPYMLIGLVFSVLAGGGQPTQAVLYAKAIST 805
Query: 2156 FSNPDRD--QMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVL 2329
S P+ +++ D FW+LMF V+ +Q + + F V +ERL R RS +R +L
Sbjct: 806 LSLPESQYSKLRHDADFWSLMFFVVGIIQFITQSTNGAAFAVCSERLIRRARSTAFRTIL 865
Query: 2330 RQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQM 2509
RQD +FD ++S G +T+ L+T+ ++ LG+I ++G + IA GW++
Sbjct: 866 RQDIAFFDKEENSTGALTSFLSTETKHLSGVSGVTLGTILMTSTTLGAAIIIALAIGWKL 925
Query: 2510 AFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLY 2689
A + +++ P + + E + A EA +IRTV +LT + ++
Sbjct: 926 ALVCISVVPVLLACGFYRFYMLAQFQSRSKLAYEGSANFACEATSSIRTVASLTRERDVW 985
Query: 2690 NIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVL 2869
I+ + LDA ++ + L Y + ++ FF A F +G L+ ++
Sbjct: 986 EIYHAQLDAQGRTSLISVLRSSLLYASSQALVFFCVALGFWYGGTLLGHHEY-----DIF 1040
Query: 2870 RVLFAIS---FSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LS 3037
R S F + G S+ P+ KA AA + + +P+ID + G + +
Sbjct: 1041 RFFVCFSEILFGAQSAGTVFSFAPDMGKAKNAAAEFRRLFDRKPQIDNWSEEGEKLETVE 1100
Query: 3038 GEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEG 3217
GE++ V FRYP RP P+L+GL++ VKPGQ +ALVGPSGCGKST I+LLER YD + G
Sbjct: 1101 GEIEFRNVHFRYPTRPEQPVLRGLDLTVKPGQYVALVGPSGCGKSTTIALLERFYDAIAG 1160
Query: 3218 AVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKA 3397
++ VD D+ ++N R ++LVSQEP L+ +I+ENI+ G+ + E + AC A
Sbjct: 1161 SILVDGKDISKLNINSYRSFLSLVSQEPTLYQGTIKENILLGIVEDDVPEEFLIKACKDA 1220
Query: 3398 NIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEK 3577
NI+ FI LP+G+ T VG KG LSGGQKQR+AIARAL+R+PKILLLDEATSALD+ESEK
Sbjct: 1221 NIYDFIMSLPEGFNTVVGSKGGMLSGGQKQRVAIARALLRDPKILLLDEATSALDSESEK 1280
Query: 3578 QVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQ 3757
VQ ALDAAA+ RT I VAHRLSTI A I V G++VE GTH+EL+ K+G Y+ L
Sbjct: 1281 VVQAALDAAARGRTTIAVAHRLSTIQKADVIYVFDQGKIVESGTHSELVQKKGRYYELVN 1340
Query: 3758 KQS 3766
QS
Sbjct: 1341 LQS 1343
Score = 342 bits (876), Expect = 5e-92
Identities = 223/607 (36%), Positives = 322/607 (52%), Gaps = 21/607 (3%)
Frame = +2
Query: 2018 VKANLFKILRYA-RPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDG 2194
V + F + RYA + + + + GA +P F++ F + + F Q+ D
Sbjct: 98 VNISFFGLWRYATKMDILIMVISTICAIAAGAALPLFTILFGSLASTFQRIMLYQISYDE 157
Query: 2195 HFW-----ALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMP 2359
+ L F+ L + ++ F E T +IR ++LRQ+ YFD
Sbjct: 158 FYDELTKNVLYFVYLGIGEFVTVYVSTVGFIYTGEHATQKIREYYLESILRQNIGYFD-- 215
Query: 2360 KHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFL----VMA 2527
K G +TTR+ D I+ I ++G A+A+ IA+ W++A + ++A
Sbjct: 216 KLGAGEVTTRITADTNLIQDGISEKVGLTLTALATFVTAFIIAYVKYWKLALICSSTIVA 275
Query: 2528 IFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSH 2707
+ M G ++KY S S G A E I +IR A Q KL + H
Sbjct: 276 LVLTMGGGSQFIIKYSKKSLDSYGA----GGTVAEEVISSIRNATAFGTQDKLAKQYEVH 331
Query: 2708 LDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAI 2887
LD I+ G G + + Y F G + D V + ++L VL AI
Sbjct: 332 LDEAEKWGTKNQIVMGFMIGAMFGLMYSNYGLGFWMGSRFLVDGAV--DVGDILTVLMAI 389
Query: 2888 ---SFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSG-TYPQLSGEVKLN 3055
SFS G + A F A AA IF ++ + +D ++ G T G ++L
Sbjct: 390 LIGSFSLGNVSPNAQAFTN---AVAAAAKIFGTIDRQSPLDPYSNEGKTLDHFEGHIELR 446
Query: 3056 KVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDN 3235
V YP RP V +++ +++ + G+T ALVGPSG GKSTV+ L+ER Y P+ G V +D
Sbjct: 447 NVKHIYPSRPEVTVMEDVSLSMPAGKTTALVGPSGSGKSTVVGLVERFYMPVRGTVLLDG 506
Query: 3236 NDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQ-------IETACSK 3394
+D++ +N + LR+ I+LVSQEP+LF T+I +NI +GL +Y +E IE A
Sbjct: 507 HDIKDLNLRWLRQQISLVSQEPVLFGTTIYKNIRHGLIGTKYENESEDKVRELIENAAKM 566
Query: 3395 ANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESE 3574
AN H FI LP+GYET VG++G LSGGQKQRIAIARA++ +PKILLLDEATSALDT+SE
Sbjct: 567 ANAHDFITALPEGYETNVGQRGFLLSGGQKQRIAIARAVVSDPKILLLDEATSALDTKSE 626
Query: 3575 KQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALT 3754
VQ AL+ AA+ RT IV+AHRLSTI A I+V+ NG++ EQGTH+EL+ + GAY L
Sbjct: 627 GVVQAALERAAEGRTTIVIAHRLSTIKTAHNIVVLVNGKIAEQGTHDELVDRGGAYRKLV 686
Query: 3755 QKQSSNQ 3775
+ Q N+
Sbjct: 687 EAQRINE 693
>gi|27368859|emb|CAD59587.1| MDR-like ABC transporter [Oryza sativa
(japonica cultivar-group)]
Length = 1264
Score = 810 bits (2093), Expect = 0.0
Identities = 452/1255 (36%), Positives = 703/1255 (56%), Gaps = 10/1255 (0%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+ +F L+RY +D L++ VG + + G+ PLM+++ GNV +F
Sbjct: 31 VPLFSLFRYADRLDVLLMVVGTVGALGNGISQPLMTVLFGNVINSF-------------- 76
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
A V + L ++YLG G A FLQ SC+ + E+ S R R + +V+R
Sbjct: 77 --GANTSGSVLRSVTKVVLNFIYLGIGTSVASFLQVSCWTMAGERQSARIRSLYLKAVLR 134
Query: 401 QEIAWYDKN-TSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
Q+I ++D T+G +++ + ++ G+K G ++++ FIGGF +AFT WLLTL
Sbjct: 135 QDITFFDTEMTTGEAVSRMSSDTLLIQGALGEKGGKLVELLSSFIGGFIIAFTRGWLLTL 194
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
+M++ P + I Y+ AG E+ + SIRTV++FNG++
Sbjct: 195 VMLTSLPLIAIASAVSAQALTRVSSKRQTSYSDAGDTVEQTIGSIRTVVSFNGEKKAIAM 254
Query: 758 YEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFF 937
Y + ++ K I++ + G G+ S +++ SY LAFW G + G ++T+ F
Sbjct: 255 YRNFIKKSYKATIEEGIITGFGMGSVMCVVFGSYGLAFWYGGKLIIEKGYTGGKIMTILF 314
Query: 938 SVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNK 1117
+V+ G+ +LG A A + AA +L++ I+R PEID+ G ++G I +
Sbjct: 315 AVLTGASSLGNATPAVAAVVEGQSAAYNLFKTIERKPEIDSDDNNGMVLEDMNGDIELKD 374
Query: 1118 VEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDI 1297
V F YP R + IL G+SL G T+A+VG SG GKST+I L++RFY+P +G++LID I
Sbjct: 375 VYFRYPARPEQLILDGLSLQVASGTTMAIVGESGSGKSTVISLVERFYDPQSGEVLIDGI 434
Query: 1298 PIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTF 1477
I+ + ++R +G+VSQEP LF SI+ NI YG+ D + E+I RA + ANAA+FI
Sbjct: 435 SIKKLRLDWIRGKIGLVSQEPLLFMASIKDNIIYGKKDATLEEIKRAAELANAANFIDKL 494
Query: 1478 PEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENA 1657
P G +TLVG RG Q+SGGQKQRIAIARA++++PKILLLDEATSALD ESE IVQ AL
Sbjct: 495 PNGYDTLVGQRGTQLSGGQKQRIAIARAILKDPKILLLDEATSALDVESERIVQEALNRM 554
Query: 1658 SRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLI-EQKGLYHELVHAQVFADVD 1834
RTT+V+AHRLSTVRN D I V++ G+++E G H+ L+ + G Y +L+ Q D
Sbjct: 555 MVERTTLVVAHRLSTVRNVDCITVVRKGKIVEQGPHDALVKDPDGAYSQLIRLQE-THRD 613
Query: 1835 DKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXX-----XXXXXXXXXXXXXXXXXXX 1999
++ K ++ + + + +R + +F ++ ++
Sbjct: 614 ERHKLPDSRSKSTSLSFRRSRTKDFLSKSNRYSFKSPLGLPVDIHEDGMTSEQQKVDHSD 673
Query: 2000 XXXXGAVKANLF-KILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRD 2176
A+K F ++ +PE + G ++P + + ++ F P D
Sbjct: 674 NSDSKAIKKTPFGRLFNLNKPEVPVLLLGSIAASVHGVILPLYGIIMPGVLKSFYEPP-D 732
Query: 2177 QMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDM 2356
Q++KD FWALM +VL S+ + LFG+A +L R+R+ ++ ++ Q+ +FD
Sbjct: 733 QLRKDSRFWALMSVVLGVACLISIPAEYFLFGIAGGKLIQRVRTLSFQRIMHQEVAWFDK 792
Query: 2357 PKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFP 2536
P +S G + TRL+ DA N++ + L I A+A++ G IAF W++A ++ + P
Sbjct: 793 PSNSSGALGTRLSVDALNVRRLVGDNLALIVQAVATLITGFAIAFAADWRLALIITCVIP 852
Query: 2537 FMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDA 2716
+ +K+ G + + E+A + A +A+ +IRTV + + ++ I+ +A
Sbjct: 853 LVGAQGYAQVKFLKGFSEESKEMYEDANQVAADAVGSIRTVASFCSEKRVVAIYNKKCEA 912
Query: 2717 PHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFS 2896
I I+ G+ F+N + + TY F G + +V +V FA+ +
Sbjct: 913 LRKQGIRSGIVGGIGLSFSNLMLYLTYGLCFYVGAKFVSQGKTTF--SDVFKVFFALVLA 970
Query: 2897 FGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKLNKVFFRY 3073
+ +++ KA +A IF++++ + RID + G + ++G + N V F+Y
Sbjct: 971 AVGVSQSSALSTNATKARDSAISIFSIIDRKSRIDSSSDEGAIMENVTGSIDFNNVSFKY 1030
Query: 3074 PERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQM 3253
P RP V I +H+ +T+ALVG SG GKST+I+LLER YDP G +++D ++R +
Sbjct: 1031 PSRPDVQIFSDFTLHIPSQKTIALVGESGSGKSTIIALLERFYDPDSGNISLDGVEIRSL 1090
Query: 3254 NPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDG 3433
LR + LV QEP+LF+ +IR NI YG + E T E+I AN H+F+ LP G
Sbjct: 1091 KVSWLRDQMGLVGQEPVLFNDTIRANITYG-KHSEVTEEEITAVAKAANAHEFVSSLPQG 1149
Query: 3434 YETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKD 3613
Y+T VGEKG QLSGGQKQR+AIARA++++PKILLLDEATSALD ESE+ VQ ALD +
Sbjct: 1150 YDTVVGEKGVQLSGGQKQRVAIARAILKDPKILLLDEATSALDAESERVVQDALDRVMVN 1209
Query: 3614 RTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELI-AKRGAYFALTQKQSSNQ 3775
RT IVVAHRLSTI A I V+K G++ E+G H L+ K GAY +L Q +S+++
Sbjct: 1210 RTTIVVAHRLSTIKGADMIAVLKEGKIAEKGKHEALLRIKDGAYASLVQLRSNSE 1264
Score = 365 bits (938), Expect = 3e-99
Identities = 220/588 (37%), Positives = 333/588 (56%), Gaps = 3/588 (0%)
Frame = +2
Query: 2021 KANLFKILRYA-RPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGH 2197
K LF + RYA R + + L G P ++ F +IN F + +
Sbjct: 30 KVPLFSLFRYADRLDVLLMVVGTVGALGNGISQPLMTVLFGNVINSFGANTSGSVLRSVT 89
Query: 2198 FWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGR 2377
L F+ L + Q S + +A ER + RIRS + VLRQD T+FD + + G
Sbjct: 90 KVVLNFIYLGIGTSVASFLQVSCWTMAGERQSARIRSLYLKAVLRQDITFFDT-EMTTGE 148
Query: 2378 ITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQA 2557
+R+++D I+ A+ + G + ++S GG IAF GW + +++ P +A+ A
Sbjct: 149 AVSRMSSDTLLIQGALGEKGGKLVELLSSFIGGFIIAFTRGWLLTLVMLTSLPLIAIASA 208
Query: 2558 LMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNIS 2737
+ + ++ +AG T + I +IRTV + + K ++ + + + I
Sbjct: 209 VSAQALTRVSSKRQTSYSDAGDTVEQTIGSIRTVVSFNGEKKAIAMYRNFIKKSYKATIE 268
Query: 2738 KAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFA 2917
+ II G G + F +Y AF +G LI +K ++ +LFA+ ++G A
Sbjct: 269 EGIITGFGMGSVMCVVFGSYGLAFWYGGKLIIEKGYT--GGKIMTILFAVLTGASSLGNA 326
Query: 2918 ASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSG-TYPQLSGEVKLNKVFFRYPERPAVP 3094
++ AA +F +E +P ID ++G ++G+++L V+FRYP RP
Sbjct: 327 TPAVAAVVEGQSAAYNLFKTIERKPEIDSDDNNGMVLEDMNGDIELKDVYFRYPARPEQL 386
Query: 3095 ILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRK 3274
IL GL++ V G T+A+VG SG GKSTVISL+ER YDP G V +D ++++ +R
Sbjct: 387 ILDGLSLQVASGTTMAIVGESGSGKSTVISLVERFYDPQSGEVLIDGISIKKLRLDWIRG 446
Query: 3275 HIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGE 3454
I LVSQEP+LF SI++NI+YG + + T E+I+ A AN FID+LP+GY+T VG+
Sbjct: 447 KIGLVSQEPLLFMASIKDNIIYGKK--DATLEEIKRAAELANAANFIDKLPNGYDTLVGQ 504
Query: 3455 KGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVA 3634
+GTQLSGGQKQRIAIARA++++PKILLLDEATSALD ESE+ VQ AL+ +RT +VVA
Sbjct: 505 RGTQLSGGQKQRIAIARAILKDPKILLLDEATSALDVESERIVQEALNRMMVERTTLVVA 564
Query: 3635 HRLSTIVNAGCIMVVKNGQVVEQGTHNELIA-KRGAYFALTQKQSSNQ 3775
HRLST+ N CI VV+ G++VEQG H+ L+ GAY L + Q +++
Sbjct: 565 HRLSTVRNVDCITVVRKGKIVEQGPHDALVKDPDGAYSQLIRLQETHR 612
>gi|50543630|ref|XP_499981.1| hypothetical protein [Yarrowia
lipolytica]
gi|49645846|emb|CAG83910.1| unnamed protein product [Yarrowia
lipolytica CLIB99]
Length = 1254
Score = 807 bits (2085), Expect = 0.0
Identities = 474/1254 (37%), Positives = 685/1254 (53%), Gaps = 17/1254 (1%)
Frame = +2
Query: 56 LYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAA 235
L RY + +D+ + V + S G LPL ++I G+++ FV + A
Sbjct: 35 LLRYATPLDKAEILVSYVFSACAGACLPLFTLIFGSMTNEFVRYFV-----------EGA 83
Query: 236 ARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAW 415
AEF H++ ++YL GIFA FL+ + + EKL+ R R + ++MRQ I +
Sbjct: 84 TPAEFGHQINYLARYFIYLFAGIFAFSFLETYMHVQMGEKLTGRIRAHYLEAIMRQNIGF 143
Query: 416 YDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLS 595
+DK +G ++N++ + ++EG +K GL +A I F + F W LTLIMMS
Sbjct: 144 FDKVGAGEITNRITTDTNLIQEGISEKAGLIVSSIAAIISAFIIGFIKSWKLTLIMMSSF 203
Query: 596 PFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALE 775
++ A A +AEEVL +IR V+AF Q+ ++Y+D L
Sbjct: 204 FALLFAMTTAVYFVVKFAKLAIVSDAKASSVAEEVLGAIRNVVAFGTQDRLTQKYDDRLV 263
Query: 776 HGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGS 955
K I + A +AS + I Y +Y L+FW G+ V G++ G ++TV F+VM+G+
Sbjct: 264 VSMKYHIFRGRGSAAAIASVWTIAYLNYALSFWEGSRLVSWGQVNVGNIMTVLFAVMIGA 323
Query: 956 MALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYP 1135
+ +G +G+A+ + ++E IDR+P ID++S +GQ ++ G I + V F YP
Sbjct: 324 VMVGNVAPNLQAMGSAIASGQKIFETIDRVPPIDSFSDKGQKLDQVHGHIQLEHVNFRYP 383
Query: 1136 TRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFN 1315
+R DV +L SL+ +PGQTVALVG+SG GKSTII +L+RFY G++ ID + I N
Sbjct: 384 SRPDVSVLHDFSLEIKPGQTVALVGASGSGKSTIIGILERFYEILGGKVTIDGVDISSLN 443
Query: 1316 IKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDED---------IARALKEANAADFI 1468
+++LRQ + +VSQEP LF SI +NI YG E+ + A ++ANA DFI
Sbjct: 444 VRWLRQQLALVSQEPTLFGVSIYENIAYGLIGTPHENADPEKKRQLVEDAARQANAYDFI 503
Query: 1469 KTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSAL 1648
+ +G T VGDRG +SGGQKQRIAIARA+VR PKILLLDEATSALD +SE IVQ AL
Sbjct: 504 QDLTDGFETNVGDRGFLLSGGQKQRIAIARAIVREPKILLLDEATSALDTKSEGIVQDAL 563
Query: 1649 ENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFAD 1828
+ A+ RTTIVIAHRLSTV+NAD I+VM G ++E GTH LIEQKG+Y LV++Q
Sbjct: 564 DKAAADRTTIVIAHRLSTVKNADLIVVMNKGSIVEQGTHHELIEQKGMYFSLVNSQTIMK 623
Query: 1829 VDDKPKKKEAERRMSRQ--TSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXX 2002
+D A+ ++ Q +F E + +
Sbjct: 624 QNDDGSDTAADDKLEEDVVAIQSLTMSSFSEDEEEYN----------------------T 661
Query: 2003 XXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDR--D 2176
G ++ F + Y + E + G P ++ F++ I F P
Sbjct: 662 KEQGIIEMIRF-VYSYNKEETTLLLIGGACAFVGGIGYPGMAVIFAKCIEAFMTPPSGYP 720
Query: 2177 QMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDM 2356
M+ + + +F ++A ++ + + S+ +A ERL ++R V++ LR D +FD
Sbjct: 721 HMRSLINTYTGLFFMIAMIEMVAFYVEISILTLAGERLVRKLRLAVFKQFLRMDIGFFDR 780
Query: 2357 PKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFP 2536
+++ G +T+ L DA N++ G I +I +V G ++ + W+M + A P
Sbjct: 781 EENTTGSLTSNLGKDAHNVRGLSGTTFGQILVSIVTVVAGFVVSVVFNWRMGLICGACIP 840
Query: 2537 FMAVGQALMMKYHGGSATSDAK-EMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLD 2713
+ +G Y + AK E +G A E IRTV LT + ++Y + ++
Sbjct: 841 IL-IGCGFCRYYVLTWLNNRAKLAYEQSGSYACENTNAIRTVTTLTREYQVYKTYKESVE 899
Query: 2714 APHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISF 2893
G+ + +G + S+ AF +G L+ K+ + P AI F
Sbjct: 900 GQVQGSKRPIFFSSILFGLSQSLSPLIMGLAFWYGGILL--KHHTISPFRFFVAFIAIVF 957
Query: 2894 SFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTY---PQLSGEVKLNKVF 3064
+ G ++ P+ KA + I N+L EP ID + GT + G ++ V
Sbjct: 958 GSQSAGSIFTFAPDMSKAAGSTRNIMNVLAVEPEIDWWSDQGTKIDPKDVKGNIEFQNVH 1017
Query: 3065 FRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDL 3244
FRYP R VP+L+GLN+ +K GQ +ALVG SGCGKST + LLE Y P G + +D DL
Sbjct: 1018 FRYPTRMQVPVLRGLNLSIKQGQYVALVGSSGCGKSTTVGLLECFYRPTSGKILLDGLDL 1077
Query: 3245 RQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDEL 3424
+N R+ +ALV QEPILF +I+ENI+ G Q + T E + A K+NIH FI L
Sbjct: 1078 ADLNINSYREAVALVQQEPILFSGTIKENILLGTQDPDVTDEVVYEAARKSNIHDFIMSL 1137
Query: 3425 PDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAA 3604
P+GY+T G KG+ LSGGQKQRIAIARALIRNPKILLLDEATSALD+ESEK VQ ALDAA
Sbjct: 1138 PEGYDTVCGSKGSLLSGGQKQRIAIARALIRNPKILLLDEATSALDSESEKVVQAALDAA 1197
Query: 3605 AKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQS 3766
AK RT I +AHRLSTI NA I V +NG V+E GTH +L+A R Y+ L + Q+
Sbjct: 1198 AKGRTTIAIAHRLSTIQNADVIFVFENGVVLESGTHQQLLANRSKYYELVKLQA 1251
Score = 342 bits (878), Expect = 3e-92
Identities = 233/608 (38%), Positives = 325/608 (53%), Gaps = 21/608 (3%)
Frame = +2
Query: 2039 ILRYARP-EWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSN--PDRDQMKKDGH---F 2200
+LRYA P + GA +P F+L F + N F + + GH +
Sbjct: 35 LLRYATPLDKAEILVSYVFSACAGACLPLFTLIFGSMTNEFVRYFVEGATPAEFGHQINY 94
Query: 2201 WALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRI 2380
A F+ L A + + E+LT RIR+ ++RQ+ +FD K G I
Sbjct: 95 LARYFIYLFAGIFAFSFLETYMHVQMGEKLTGRIRAHYLEAIMRQNIGFFD--KVGAGEI 152
Query: 2381 TTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVM----AIFPFMAV 2548
T R+ TD I+ I + G I ++IA++ I F W++ ++M A+ M
Sbjct: 153 TNRITTDTNLIQEGISEKAGLIVSSIAAIISAFIIGFIKSWKLTLIMMSSFFALLFAMTT 212
Query: 2549 GQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGG 2728
++K+ + SDAK A A E + IR V A Q +L + L
Sbjct: 213 AVYFVVKFAKLAIVSDAK----ASSVAEEVLGAIRNVVAFGTQDRLTQKYDDRLVVSMKY 268
Query: 2729 NISKAIIRGLTYGFAN--SIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFG 2902
+I + RG A+ +I + YA +F G L+ V + N++ VLFA+
Sbjct: 269 HIFRG--RGSAAAIASVWTIAYLNYALSFWEGSRLVSWGQVNVG--NIMTVLFAVMIGAV 324
Query: 2903 TIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGT-YPQLSGEVKLNKVFFRYPE 3079
+G A A + IF ++ P ID + G Q+ G ++L V FRYP
Sbjct: 325 MVGNVAPNLQAMGSAIASGQKIFETIDRVPPIDSFSDKGQKLDQVHGHIQLEHVNFRYPS 384
Query: 3080 RPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNP 3259
RP V +L ++ +KPGQT+ALVG SG GKST+I +LER Y+ L G VT+D D+ +N
Sbjct: 385 RPDVSVLHDFSLEIKPGQTVALVGASGSGKSTIIGILERFYEILGGKVTIDGVDISSLNV 444
Query: 3260 KHLRKHIALVSQEPILFDTSIRENIVYGL-------QPGEYTHEQIETACSKANIHKFID 3418
+ LR+ +ALVSQEP LF SI ENI YGL E + +E A +AN + FI
Sbjct: 445 RWLRQQLALVSQEPTLFGVSIYENIAYGLIGTPHENADPEKKRQLVEDAARQANAYDFIQ 504
Query: 3419 ELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALD 3598
+L DG+ET VG++G LSGGQKQRIAIARA++R PKILLLDEATSALDT+SE VQ ALD
Sbjct: 505 DLTDGFETNVGDRGFLLSGGQKQRIAIARAIVREPKILLLDEATSALDTKSEGIVQDALD 564
Query: 3599 AAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQS-SNQ 3775
AA DRT IV+AHRLST+ NA I+V+ G +VEQGTH+ELI ++G YF+L Q+ Q
Sbjct: 565 KAAADRTTIVIAHRLSTVKNADLIVVMNKGSIVEQGTHHELIEQKGMYFSLVNSQTIMKQ 624
Query: 3776 SGGAFDTS 3799
+ DT+
Sbjct: 625 NDDGSDTA 632
>gi|266518|sp|Q00449|MDR4_DROME Multidrug resistance protein homolog
49 (P-glycoprotein 49)
gi|103251|pir||A41249 multidrug resistance protein homolog Mdr49 -
fruit fly (Drosophila melanogaster)
gi|157871|gb|AAA28679.1| P glycoprotein
gi|16198339|gb|AAL14020.1| SD10012p [Drosophila melanogaster]
Length = 1302
Score = 807 bits (2084), Expect = 0.0
Identities = 464/1265 (36%), Positives = 692/1265 (54%), Gaps = 32/1265 (2%)
Frame = +2
Query: 44 SIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFV-------TLGTIFL 202
S F L+RY++ +R +L V ++V+ A +P II G + V T F
Sbjct: 30 SYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGEFTSLLVDRTVGVGTSSPAFA 89
Query: 203 DPNSTASEKA--AARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLS----N 364
P ++ A++ E + +I + + A FL + + + +++ +
Sbjct: 90 LPMFGGGQQLTNASKEENNQAIIDDATAFGIGSLVGSVAMFLLITLAIDLANRIALNQID 149
Query: 365 RFRRQFFHSVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFA 544
R R+ F +++RQ+IAWYD ++ ++K+ ++L++++EG G+K+ + ++ F+ G
Sbjct: 150 RIRKLFLEAMLRQDIAWYDTSSGSNFASKMTEDLDKLKEGIGEKIVIVVFLIMTFVIGIV 209
Query: 545 VAFTYDWLLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVI 724
AF Y W LTL+++S PF++ Y+ A + EEV + IRTV
Sbjct: 210 SAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEEVFSGIRTVF 269
Query: 725 AFNGQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGR 904
AF+GQE E +R+ L + TG KK G G A ++IIY LA W G + R
Sbjct: 270 AFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGVTLILDER 329
Query: 905 LESGTVLT------VFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYS 1066
V T V F+V+MG+ LG A I A A +L+ +IDR ++D
Sbjct: 330 DLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMD 389
Query: 1067 TEGQTPSKISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQL 1246
+G P +G I + F YP R DV+ILKG+++D PGQTVA VG+SGCGKST+IQL
Sbjct: 390 EKGNRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQL 449
Query: 1247 LQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDED 1426
+QRFY+P+AG + +D + N+ +LR +GVV QEP LF T+I +NIRYGR + D
Sbjct: 450 MQRFYDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQAD 509
Query: 1427 IARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATS 1606
I +A + AN DFI P+G +T VG++G Q+SGGQKQRIAIARALVR P++LLLDEATS
Sbjct: 510 IEKAARAANCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATS 569
Query: 1607 ALDAESESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQK 1786
ALD SE VQSALE AS+G TT+V+AHRLST+ NADKI+ +K G V E GTHE L+E++
Sbjct: 570 ALDPTSEKRVQSALELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMERR 629
Query: 1787 GLYHELVHAQVFADVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXX 1966
GLY ELV + + + A R + + + + ++ + D
Sbjct: 630 GLYCELVSITQRKEATEADEGAVAGRPLQKSQNLSDEETDDDEEDEEEDEEPELQTSGSS 689
Query: 1967 XXXXXXXXXXXXXXXG----------AVKANLFKILRYARPEWIYXXXXXXXXLIQGAVM 2116
K + ++++ PEW + ++ GA
Sbjct: 690 RDSGFRASTRRKRRSQRRKKKKDKEVVSKVSFTQLMKLNSPEWRFIVVGGIASVMHGATF 749
Query: 2117 PAFSLFFSQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTM 2296
P + LFF + S+ D D ++ + +++F+ + + G + Q +F A ++T
Sbjct: 750 PLWGLFFGDFFGILSDGDDDVVRAEVLKISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTT 809
Query: 2297 RIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGG 2476
R+R + + ++ QD YFD ++S G + +RLA+D N++ A R+G++ A+A++ G
Sbjct: 810 RLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASDCSNVQGATGARVGTMLQAVATLVVG 869
Query: 2477 LGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRT 2656
+ + F + WQ L + P + + L ++ SA +E A + A+EAI NIRT
Sbjct: 870 MVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQKAKASIEEASQVAVEAITNIRT 929
Query: 2657 VQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFD 2836
V L L+ ++ + + +D K RGL + + F Y + +G L+ +
Sbjct: 930 VNGLCLERQVLDQYVQQIDRVDVACRRKVRFRGLVFALGQAAPFLAYGISMYYGGILVAE 989
Query: 2837 KNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSS 3016
+ M E++++V A+ F +G A +Y P A +AG + ++ + S
Sbjct: 990 ER--MNYEDIIKVAEALIFGSWMLGQALAYAPNVNDAILSAGRLMDLFKRTSTQPNPPQS 1047
Query: 3017 --GTYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLL 3190
T + G++ V F YP R PILQGLN+ +K T+ALVGPSG GKST + LL
Sbjct: 1048 PYNTVEKSEGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLL 1107
Query: 3191 ERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQ-PGEYTH 3367
R YDP+ G+V + + LR + LVSQEP+LFD +I ENI YG + +
Sbjct: 1108 LRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSM 1167
Query: 3368 EQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEA 3547
++I A K+NIH FI LP GY+TR+G K +QLSGGQKQRIAIARAL+RNPKIL+LDEA
Sbjct: 1168 QEIIEAAKKSNIHNFISALPQGYDTRLG-KTSQLSGGQKQRIAIARALVRNPKILILDEA 1226
Query: 3548 TSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIA 3727
TSALD ESEK VQ ALD A RTC+ +AHRL+T+ NA I V+K G VVE GTH+EL+A
Sbjct: 1227 TSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELMA 1286
Query: 3728 KRGAY 3742
Y
Sbjct: 1287 LNKIY 1291
Score = 349 bits (896), Expect = 3e-94
Identities = 218/574 (37%), Positives = 312/574 (53%), Gaps = 16/574 (2%)
Frame = +2
Query: 2105 GAVMPAFSLFF----SQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFG 2272
G PAF+L Q+ N + + D A F + + V +M +L
Sbjct: 82 GTSSPAFALPMFGGGQQLTNASKEENNQAIIDD----ATAFGIGSLVGSVAMFLLITLAI 137
Query: 2273 VAAERLTM----RIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLG 2440
A R+ + RIR +LRQD ++D S +++ D +K I ++
Sbjct: 138 DLANRIALNQIDRIRKLFLEAMLRQDIAWYDTSSGS--NFASKMTEDLDKLKEGIGEKIV 195
Query: 2441 SIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAG 2620
+ I + G+ AF YGW++ +V++ PF+ +++ + G A + K +A
Sbjct: 196 IVVFLIMTFVIGIVSAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAA 255
Query: 2621 KTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYA 2800
E IRTV A + Q K F L K + G+ + I + A
Sbjct: 256 NVVEEVFSGIRTVFAFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMA 315
Query: 2801 AAFRFGLFLIFDKNVLME----PENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLI 2968
A +G+ LI D+ L + P ++ VLFA+ +GFA+ + AT A +
Sbjct: 316 LAIWYGVTLILDERDLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTL 375
Query: 2969 FNMLEEEPRIDGMTSSGTYPQ-LSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLAL 3145
FN+++ ++D M G P+ +G ++ + FRYP RP V IL+GL V V PGQT+A
Sbjct: 376 FNIIDRPSQVDPMDEKGNRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAF 435
Query: 3146 VGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIR 3325
VG SGCGKST+I L++R YDP G+V +D DLR +N LR I +V QEP+LF T+I
Sbjct: 436 VGASGCGKSTLIQLMQRFYDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIG 495
Query: 3326 ENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIAR 3505
ENI YG T IE A AN H FI LP GY+T+VGEKG Q+SGGQKQRIAIAR
Sbjct: 496 ENIRYGRPSA--TQADIEKAARAANCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIAR 553
Query: 3506 ALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKN 3685
AL+R P++LLLDEATSALD SEK+VQ AL+ A++ T +VVAHRLSTI NA I+ +K+
Sbjct: 554 ALVRQPQVLLLDEATSALDPTSEKRVQSALELASQGPTTLVVAHRLSTITNADKIVFLKD 613
Query: 3686 GQVVEQGTHNELIAKRGAY---FALTQKQSSNQS 3778
G V EQGTH EL+ +RG Y ++TQ++ + ++
Sbjct: 614 GVVAEQGTHEELMERRGLYCELVSITQRKEATEA 647
Score = 305 bits (780), Expect = 7e-81
Identities = 205/596 (34%), Positives = 307/596 (51%), Gaps = 8/596 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+S QL + S R ++ VG I S G PL + G+ G + +
Sbjct: 719 VSFTQLMKLNSPEWRFIV-VGGIASVMHGATFPLWGLFFGDF------FGIL------SD 765
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAA--GFLQASCFMVICEKLSNRFRRQFFHSV 394
+ RAE + +++G G+ A LQ F K++ R R++ F ++
Sbjct: 766 GDDDVVRAEVLK------ISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTI 819
Query: 395 MRQEIAWYD--KNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWL 568
+ Q+IA++D +N+ G L ++L + V+ TG +VG Q +A + G V F + W
Sbjct: 820 IGQDIAYFDDERNSVGALCSRLASDCSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQ 879
Query: 569 LTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYE 748
TL+ + P + + A +A E +T+IRTV +
Sbjct: 880 QTLLTLVTLPLVCLSVYLEGRFIMKSAQKAKASIEEASQVAVEAITNIRTVNGLCLERQV 939
Query: 749 CKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLT 928
+Y ++ +K G A + +Y ++ + G V R+ ++
Sbjct: 940 LDQYVQQIDRVDVACRRKVRFRGLVFALGQAAPFLAYGISMYYGGILVAEERMNYEDIIK 999
Query: 929 VFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIP-EIDAYSTEGQTPSKISGRI 1105
V +++ GS LGQA + A+ +A L ++ R + + + T K G I
Sbjct: 1000 VAEALIFGSWMLGQALAYAPNVNDAILSAGRLMDLFKRTSTQPNPPQSPYNTVEKSEGDI 1059
Query: 1106 SVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQIL 1285
V F YPTR IL+G++L + TVALVG SG GKST +QLL R+Y+P +G +
Sbjct: 1060 VYENVGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVN 1119
Query: 1286 IDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYG---RSDVSDEDIARALKEANA 1456
+ +P +F + LR +G+VSQEP LF+ +I +NI YG R DVS ++I A K++N
Sbjct: 1120 LSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNI 1179
Query: 1457 ADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIV 1636
+FI P+G +T +G Q+SGGQKQRIAIARALVRNPKIL+LDEATSALD ESE +V
Sbjct: 1180 HNFISALPQGYDTRLGKTS-QLSGGQKQRIAIARALVRNPKILILDEATSALDLESEKVV 1238
Query: 1637 QSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHEL 1804
Q AL+ A GRT + IAHRL+TVRNAD I V+K G V+E GTH+ L+ +Y L
Sbjct: 1239 QQALDEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELMALNKIYANL 1294
>gi|24653245|ref|NP_523724.2| CG3879-PA [Drosophila melanogaster]
gi|21627300|gb|AAF58437.2| CG3879-PA [Drosophila melanogaster]
Length = 1302
Score = 806 bits (2083), Expect = 0.0
Identities = 464/1265 (36%), Positives = 692/1265 (54%), Gaps = 32/1265 (2%)
Frame = +2
Query: 44 SIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFV-------TLGTIFL 202
S F L+RY++ +R +L V ++V+ A +P II G + V T F
Sbjct: 30 SYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGEFTSLLVDRTVGVGTSSPAFA 89
Query: 203 DPNSTASEKA--AARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLS----N 364
P ++ A++ E + +I + + A FL + + + +++ +
Sbjct: 90 LPMFGGGQQLTNASKEENNQAIIDDATAFGIGSLVGSVAMFLLITLAIDLANRIALNQID 149
Query: 365 RFRRQFFHSVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFA 544
R R+ F +++RQ+IAWYD ++ ++K+ ++L++++EG G+K+ + ++ F+ G
Sbjct: 150 RIRKLFLEAMLRQDIAWYDTSSGSNFASKMTEDLDKLKEGIGEKIVIVVFLIMTFVIGIV 209
Query: 545 VAFTYDWLLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVI 724
AF Y W LTL+++S PF++ Y+ A + EEV + IRTV
Sbjct: 210 SAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEEVFSGIRTVF 269
Query: 725 AFNGQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGR 904
AF+GQE E +R+ L + TG KK G G A ++IIY LA W G + R
Sbjct: 270 AFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGVTLILDER 329
Query: 905 LESGTVLT------VFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYS 1066
V T V F+V+MG+ LG A I A A +L+ +IDR ++D
Sbjct: 330 DLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMD 389
Query: 1067 TEGQTPSKISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQL 1246
+G P +G I + F YP R DV+ILKG+++D PGQTVA VG+SGCGKST+IQL
Sbjct: 390 EKGNRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQL 449
Query: 1247 LQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDED 1426
+QRFY+P+AG + +D + N+ +LR +GVV QEP LF T+I +NIRYGR + D
Sbjct: 450 MQRFYDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQAD 509
Query: 1427 IARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATS 1606
I +A + AN DFI P+G +T VG++G Q+SGGQKQRIAIARALVR P++LLLDEATS
Sbjct: 510 IEKAARAANCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATS 569
Query: 1607 ALDAESESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQK 1786
ALD SE VQSALE AS+G TT+V+AHRLST+ NADKI+ +K G V E GTHE L+E++
Sbjct: 570 ALDPTSEKRVQSALELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMERR 629
Query: 1787 GLYHELVHAQVFADVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXX 1966
GLY ELV + + + A R + + + + ++ + D
Sbjct: 630 GLYCELVSITQRKEATEADEGAVAGRPLQKSQNLSDEETDDDEEDEEEDEEPELQTSGSS 689
Query: 1967 XXXXXXXXXXXXXXXG----------AVKANLFKILRYARPEWIYXXXXXXXXLIQGAVM 2116
K + ++++ PEW + ++ GA
Sbjct: 690 RDSGFRASTRRKRRSQRRKKKKDKEVVSKVSFTQLMKLNSPEWRFIVVGGIASVMHGATF 749
Query: 2117 PAFSLFFSQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTM 2296
P + LFF + S+ D D ++ + +++F+ + + G + Q +F A ++T
Sbjct: 750 PLWGLFFGDFFGILSDGDDDVVRAEVLKISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTT 809
Query: 2297 RIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGG 2476
R+R + + ++ QD YFD ++S G + +RLA+D N++ A R+G++ A+A++ G
Sbjct: 810 RLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASDCSNVQGATGARVGTMLQAVATLVVG 869
Query: 2477 LGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRT 2656
+ + F + WQ L + P + + L ++ SA +E A + A+EAI NIRT
Sbjct: 870 MVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQKAKASIEEASQVAVEAITNIRT 929
Query: 2657 VQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFD 2836
V L L+ ++ + + +D K RGL + + F Y + +G L+ +
Sbjct: 930 VNGLCLERQVLDQYVQQIDRVDIACRRKVRFRGLVFALGQAAPFLAYGISMYYGGILVAE 989
Query: 2837 KNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSS 3016
+ M E++++V A+ F +G A +Y P A +AG + ++ + S
Sbjct: 990 ER--MNYEDIIKVAEALIFGSWMLGQALAYAPNVNDAILSAGRLMDLFKRTSTQPNPPQS 1047
Query: 3017 --GTYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLL 3190
T + G++ V F YP R PILQGLN+ +K T+ALVGPSG GKST + LL
Sbjct: 1048 PYNTVEKSEGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLL 1107
Query: 3191 ERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQ-PGEYTH 3367
R YDP+ G+V + + LR + LVSQEP+LFD +I ENI YG + +
Sbjct: 1108 LRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSM 1167
Query: 3368 EQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEA 3547
++I A K+NIH FI LP GY+TR+G K +QLSGGQKQRIAIARAL+RNPKIL+LDEA
Sbjct: 1168 QEIIEAAKKSNIHNFISALPQGYDTRLG-KTSQLSGGQKQRIAIARALVRNPKILILDEA 1226
Query: 3548 TSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIA 3727
TSALD ESEK VQ ALD A RTC+ +AHRL+T+ NA I V+K G VVE GTH+EL+A
Sbjct: 1227 TSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELMA 1286
Query: 3728 KRGAY 3742
Y
Sbjct: 1287 LNKIY 1291
Score = 349 bits (896), Expect = 3e-94
Identities = 218/574 (37%), Positives = 312/574 (53%), Gaps = 16/574 (2%)
Frame = +2
Query: 2105 GAVMPAFSLFF----SQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFG 2272
G PAF+L Q+ N + + D A F + + V +M +L
Sbjct: 82 GTSSPAFALPMFGGGQQLTNASKEENNQAIIDD----ATAFGIGSLVGSVAMFLLITLAI 137
Query: 2273 VAAERLTM----RIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLG 2440
A R+ + RIR +LRQD ++D S +++ D +K I ++
Sbjct: 138 DLANRIALNQIDRIRKLFLEAMLRQDIAWYDTSSGS--NFASKMTEDLDKLKEGIGEKIV 195
Query: 2441 SIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAG 2620
+ I + G+ AF YGW++ +V++ PF+ +++ + G A + K +A
Sbjct: 196 IVVFLIMTFVIGIVSAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAA 255
Query: 2621 KTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYA 2800
E IRTV A + Q K F L K + G+ + I + A
Sbjct: 256 NVVEEVFSGIRTVFAFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMA 315
Query: 2801 AAFRFGLFLIFDKNVLME----PENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLI 2968
A +G+ LI D+ L + P ++ VLFA+ +GFA+ + AT A +
Sbjct: 316 LAIWYGVTLILDERDLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTL 375
Query: 2969 FNMLEEEPRIDGMTSSGTYPQ-LSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLAL 3145
FN+++ ++D M G P+ +G ++ + FRYP RP V IL+GL V V PGQT+A
Sbjct: 376 FNIIDRPSQVDPMDEKGNRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAF 435
Query: 3146 VGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIR 3325
VG SGCGKST+I L++R YDP G+V +D DLR +N LR I +V QEP+LF T+I
Sbjct: 436 VGASGCGKSTLIQLMQRFYDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIG 495
Query: 3326 ENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIAR 3505
ENI YG T IE A AN H FI LP GY+T+VGEKG Q+SGGQKQRIAIAR
Sbjct: 496 ENIRYGRPSA--TQADIEKAARAANCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIAR 553
Query: 3506 ALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKN 3685
AL+R P++LLLDEATSALD SEK+VQ AL+ A++ T +VVAHRLSTI NA I+ +K+
Sbjct: 554 ALVRQPQVLLLDEATSALDPTSEKRVQSALELASQGPTTLVVAHRLSTITNADKIVFLKD 613
Query: 3686 GQVVEQGTHNELIAKRGAY---FALTQKQSSNQS 3778
G V EQGTH EL+ +RG Y ++TQ++ + ++
Sbjct: 614 GVVAEQGTHEELMERRGLYCELVSITQRKEATEA 647
Score = 304 bits (779), Expect = 9e-81
Identities = 205/596 (34%), Positives = 307/596 (51%), Gaps = 8/596 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+S QL + S R ++ VG I S G PL + G+ G + +
Sbjct: 719 VSFTQLMKLNSPEWRFIV-VGGIASVMHGATFPLWGLFFGDF------FGIL------SD 765
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAA--GFLQASCFMVICEKLSNRFRRQFFHSV 394
+ RAE + +++G G+ A LQ F K++ R R++ F ++
Sbjct: 766 GDDDVVRAEVLK------ISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTI 819
Query: 395 MRQEIAWYD--KNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWL 568
+ Q+IA++D +N+ G L ++L + V+ TG +VG Q +A + G V F + W
Sbjct: 820 IGQDIAYFDDERNSVGALCSRLASDCSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQ 879
Query: 569 LTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYE 748
TL+ + P + + A +A E +T+IRTV +
Sbjct: 880 QTLLTLVTLPLVCLSVYLEGRFIMKSAQKAKASIEEASQVAVEAITNIRTVNGLCLERQV 939
Query: 749 CKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLT 928
+Y ++ +K G A + +Y ++ + G V R+ ++
Sbjct: 940 LDQYVQQIDRVDIACRRKVRFRGLVFALGQAAPFLAYGISMYYGGILVAEERMNYEDIIK 999
Query: 929 VFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIP-EIDAYSTEGQTPSKISGRI 1105
V +++ GS LGQA + A+ +A L ++ R + + + T K G I
Sbjct: 1000 VAEALIFGSWMLGQALAYAPNVNDAILSAGRLMDLFKRTSTQPNPPQSPYNTVEKSEGDI 1059
Query: 1106 SVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQIL 1285
V F YPTR IL+G++L + TVALVG SG GKST +QLL R+Y+P +G +
Sbjct: 1060 VYENVGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVN 1119
Query: 1286 IDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYG---RSDVSDEDIARALKEANA 1456
+ +P +F + LR +G+VSQEP LF+ +I +NI YG R DVS ++I A K++N
Sbjct: 1120 LSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNI 1179
Query: 1457 ADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIV 1636
+FI P+G +T +G Q+SGGQKQRIAIARALVRNPKIL+LDEATSALD ESE +V
Sbjct: 1180 HNFISALPQGYDTRLGKTS-QLSGGQKQRIAIARALVRNPKILILDEATSALDLESEKVV 1238
Query: 1637 QSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHEL 1804
Q AL+ A GRT + IAHRL+TVRNAD I V+K G V+E GTH+ L+ +Y L
Sbjct: 1239 QQALDEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELMALNKIYANL 1294
>gi|34913530|ref|NP_918112.1| putative multidrug resistance protein
[Oryza sativa (japonica cultivar-group)]
gi|20146370|dbj|BAB89151.1| putative multidrug resistance protein
[Oryza sativa (japonica cultivar-group)]
gi|27368871|emb|CAD59593.1| MDR-like ABC transporter [Oryza sativa
(japonica cultivar-group)]
Length = 1287
Score = 806 bits (2081), Expect = 0.0
Identities = 467/1266 (36%), Positives = 711/1266 (55%), Gaps = 21/1266 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+++ +++ + D ++AVG + A G+ PLM+ I G+V F ST+
Sbjct: 42 VAVRRMFAFADGADAALMAVGAAAAVANGMAQPLMTFIFGDVINAF----------GSTS 91
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
S A+ V + L +VYLG G LQ SC+ + E+ + R R + +++R
Sbjct: 92 SPDVLAK------VTKVILNFVYLGIGAGFVSTLQVSCWTITGERQAARIRALYLKAILR 145
Query: 401 QEIAWYDKNTS-GTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
Q+IA++DK S G + ++ + +++ G+K G Q+++ F GGF +AF WLL L
Sbjct: 146 QDIAFFDKEMSTGQVVERMSGDTFLIQDAIGEKSGKCIQLLSTFFGGFIIAFVRGWLLAL 205
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
+++S P + + G F +Y AG IAE+ + +IRTV +FNG++
Sbjct: 206 VLLSCIPPIAVAGAFVSRLMTRISTRMQEKYGDAGNIAEQTIGAIRTVASFNGEKQAINT 265
Query: 758 YEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFF 937
Y + ++ +++ + G GL + I++ SY LA W G+ + + G V+ V
Sbjct: 266 YNKFIRKAYESTLQEGVVNGLGLGTVMAILFCSYGLAVWYGSKLIVNRGYNGGIVINVLM 325
Query: 938 SVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNK 1117
SVMMG+M+LGQA GAA +++ I R P+ID T+G I+G + +
Sbjct: 326 SVMMGAMSLGQATPSITAFAEGQGAAYRMFKTIKRQPDIDVCDTKGIILEDITGDVELKD 385
Query: 1118 VEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDI 1297
V F+YPTR + + G SL G+T+ALVG SG GKST+I L++RFY+P +G++LID I
Sbjct: 386 VYFSYPTRPEYLVFNGFSLQIPSGRTMALVGESGSGKSTVISLVERFYDPQSGEVLIDGI 445
Query: 1298 PIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTF 1477
I N+ ++R + +VSQEP LF+++I +NI YG+ D + E+I RA++ ANAA F+
Sbjct: 446 DIRRMNLGWIRGKISLVSQEPVLFSSTIRENIAYGKEDQTLEEIKRAVELANAAKFVDKL 505
Query: 1478 PEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENA 1657
P GL T+VG+RG+Q+SGGQKQRIAIARA+++NP+ILLLDEATSALD ESE +VQ AL
Sbjct: 506 PNGLETMVGERGIQLSGGQKQRIAIARAIIKNPRILLLDEATSALDMESERVVQDALNRV 565
Query: 1658 SRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQ-KGLYHELVH-------A 1813
RTTI++AHRLSTV+NAD I V++ G+++E G+H L+++ +G Y +L+ A
Sbjct: 566 MLERTTIIVAHRLSTVKNADVISVLQQGKMVEQGSHVELMKKPEGAYAQLIQLQGAQQDA 625
Query: 1814 QVFADVDDKPKKKEAERR------MSRQTSQR----KGSVNFKTQESQVDXXXXXXXXXX 1963
++ D D + ++ R S+ TS R KGS + +
Sbjct: 626 EIHNDDTDMIIRSDSGSRSINVKPRSQSTSFRRSITKGSSFGHSGRHPIPAPLDFPDPME 685
Query: 1964 XXXXXXXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQ 2143
G KA++ ++ +PE + G + P F + S
Sbjct: 686 FKDDLGMEETTDKVPRGQKKASISRLFYLNKPEAFVLVLGSVTAAMHGLMFPIFGILISS 745
Query: 2144 IINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRN 2323
I +F P ++ KD FWA MF+V+ A + + LFG+A +L RIRS +R+
Sbjct: 746 AIKMFYEPP-SELLKDSRFWASMFVVVGASAFVLIPTEYFLFGLAGGKLVERIRSLTFRS 804
Query: 2324 VLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGW 2503
V+ Q+ +FD P+HS G I RL+ DA N+K + L +++V G IA W
Sbjct: 805 VMHQEINWFDKPEHSSGSIGARLSVDALNVKRLVGDNLALNVQTVSTVISGFTIAMVANW 864
Query: 2504 QMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTK 2683
++A ++ + P + MK+ G + + E A + A +A+ IRTV + + K
Sbjct: 865 KLALIITVVVPLVGFQAYAQMKFLKGFNKNAKLKYEEASQVATDAVGGIRTVASFCAEQK 924
Query: 2684 LYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPEN 2863
+ + ++P I + ++ GL +GF+ + +FTYA F G + + V PE
Sbjct: 925 VIEAYEKKCESPVRQGIREGVVGGLGFGFSFLVFYFTYALCFYVGAKFV-HQGVATFPE- 982
Query: 2864 VLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSG-TYPQLSG 3040
V RV F + + I ++ + KA +A IF +L+ + +ID + G + G
Sbjct: 983 VFRVFFVLVLATSGISRTSAIGADSTKANESAVSIFEILDRKSKIDSSSEEGVVIASVRG 1042
Query: 3041 EVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGA 3220
+++ + V F YP RP + I + L++ + G+T+ALVG SG GKST I+LLER YDP G
Sbjct: 1043 DIEFHNVCFNYPLRPNIQIFKDLSLCIPSGKTVALVGESGSGKSTAIALLERFYDPDTGK 1102
Query: 3221 VTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKAN 3400
+ +D DL+ LR I LV+QEP+LF+ +I NI YG Q + + E+I A AN
Sbjct: 1103 ILLDGVDLKTFKVSWLRIQIGLVAQEPVLFNDTIHANIAYGKQE-QASQEEIMAAAEAAN 1161
Query: 3401 IHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQ 3580
H+FI LPDGY T VGE+G QLSGGQKQR+AIARA++++PK+LLLDEATSALD ESE+
Sbjct: 1162 AHQFISALPDGYSTVVGERGIQLSGGQKQRVAIARAIMKDPKVLLLDEATSALDAESERV 1221
Query: 3581 VQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELI-AKRGAYFALTQ 3757
VQ ALD RT +VVAHRLSTI A I V+KNG +VE+G H+EL+ K G Y +L +
Sbjct: 1222 VQEALDRVMVGRTTVVVAHRLSTIKGADIIGVLKNGAIVEKGGHDELMRIKDGTYASLVE 1281
Query: 3758 KQSSNQ 3775
SS++
Sbjct: 1282 LSSSSR 1287
>gi|25407562|pir||H85202 hypothetical protein AT4g18050 [imported] -
Arabidopsis thaliana
gi|7268557|emb|CAB78807.1| multidrug resistance
protein/P-glycoprotein-like [Arabidopsis thaliana]
Length = 1323
Score = 805 bits (2078), Expect = 0.0
Identities = 476/1270 (37%), Positives = 699/1270 (54%), Gaps = 43/1270 (3%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+S F+L+ + D +++ VG I + G+ P M++I G + F T DP+
Sbjct: 16 VSFFKLFSFADKTDVVLMTVGTIAAAGNGLTQPFMTLIFGQLINAFGTT-----DPDHMV 70
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
EV + +K++YL FLQ SC+MV E+ S R + +++R
Sbjct: 71 -----------REVWKVAVKFIYLAVYSCVVAFLQVSCWMVTGERQSATIRGLYLKTILR 119
Query: 401 QEIAWYDKNTS-GTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
Q+I ++D T+ G + ++ + +++ G+KVG Q++ F+GGFA+AF LL
Sbjct: 120 QDIGYFDTETNTGEVIGRMSGDTILIQDAMGEKVGKFTQLLCTFLGGFAIAFYKGPLLAG 179
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
++ S P ++I G YA AG + E+ + +IRTV+AF G++ ++
Sbjct: 180 VLCSCIPLIVIAGAAMSLIMSKMAGRGQVAYAEAGNVVEQTVGAIRTVVAFTGEKQATEK 239
Query: 758 YEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFF 937
YE LE KT +++ + G GL + +I+ SY LA W G + G V+ V F
Sbjct: 240 YESKLEIAYKTVVQQGLISGFGLGTMLAVIFCSYGLAVWYGAKLIMEKGYNGGQVINVIF 299
Query: 938 SVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNK 1117
+V+ G M+LGQ AA ++E I R P+IDAY G I G I +
Sbjct: 300 AVLTGGMSLGQTSPSLNAFAAGRAAAFKMFETIKRSPKIDAYDMSGSVLEDIRGDIELKD 359
Query: 1118 VEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDI 1297
V F YP R DV+I G SL G+TVALVG SG GKST+I L++RFY+P++GQ+LID+I
Sbjct: 360 VYFRYPARPDVQIFAGFSLFVPNGKTVALVGQSGSGKSTVISLIERFYDPESGQVLIDNI 419
Query: 1298 PIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTF 1477
++ +K++R +G+VSQEP LF T+I++NI YG+ D +D++I A++ ANAA FI
Sbjct: 420 DLKKLQLKWIRSKIGLVSQEPVLFATTIKENIAYGKEDATDQEIRTAIELANAAKFIDKL 479
Query: 1478 PEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENA 1657
P+GL+T+VG+ G QMSGGQKQR+AIARA+++NPKILLLDEATSALDAESE IVQ AL N
Sbjct: 480 PQGLDTMVGEHGTQMSGGQKQRLAIARAILKNPKILLLDEATSALDAESERIVQDALVNL 539
Query: 1658 SRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQ-KGLYHELVHAQVFADVD 1834
RTT+V+AHRL+T+R AD I V+ G+++E GTH+ +I+ +G Y +LV Q
Sbjct: 540 MSNRTTVVVAHRLTTIRTADVIAVVHQGKIVEKGTHDEMIQDPEGAYSQLVRLQ----EG 595
Query: 1835 DKPKKKEAERRMSRQTSQRKGSVNFKT-QESQVDXXXXXXXXXXXXXXXXXXXXXXXXXX 2011
K + E+ER + +R GS+ + V
Sbjct: 596 SKEEATESERPETSLDVERSGSLRLSSAMRRSVSRNSSSSRHSFSLASNMFFPGVNVNQT 655
Query: 2012 GAV----------KANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFS 2161
+ K +L ++ +PE ++ G V P F L S IN+F
Sbjct: 656 DEMEDEENNVRHKKVSLKRLAHLNKPEIPVLVLGSIAAMVHGTVFPIFGLLLSSSINMFY 715
Query: 2162 NPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDA 2341
P + +KKD HFWAL+++ L + FG+A +L RIRS + V+ Q+
Sbjct: 716 EPAK-ILKKDSHFWALIYIALGLTNFVMIPVPNYFFGIAGGKLIKRIRSMCFDKVVHQEI 774
Query: 2342 TYFDMPKHS---------------------------PGRITTRLATDAPNIKSAIDYRLG 2440
++FD +S P R+ +TDA ++S + L
Sbjct: 775 SWFDDTANSRYYNFIYIINRRILYVLILIFICVLLPPVRLERECSTDASTVRSLVGDALA 834
Query: 2441 SIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEM-ENA 2617
I IA+V GL IAF W +A +V+A+ PF+ + K+ G ++DAK M E A
Sbjct: 835 LIVQNIATVTTGLIIAFTANWILALIVLALSPFIVIQGYAQTKFLTG-FSADAKAMYEEA 893
Query: 2618 GKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTY 2797
+ A +A+ +IRTV + + K+ +++ D P + ++ G +GF+ +
Sbjct: 894 SQVANDAVSSIRTVASFCAEEKVMDLYQQKCDGPKKNGVRLGLLSGAGFGFSFFFLYCIN 953
Query: 2798 AAAFRFGLFLI-FDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFN 2974
F G LI K E V +V FA++ + ++ P+ KA +A IF+
Sbjct: 954 CVCFVSGAGLIQIGKATFGE---VFKVFFALTIMAIGVSQTSAMAPDSNKAKDSAASIFD 1010
Query: 2975 MLEEEPRIDGMTSSGTYPQ-LSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVG 3151
+L+ P+ID + GT Q ++G+++ V FRYP RP V I + L + + G+T+ALVG
Sbjct: 1011 ILDSTPKIDSSSDEGTTLQNVNGDIEFRHVSFRYPMRPDVQIFRDLCLTIPSGKTVALVG 1070
Query: 3152 PSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIREN 3331
SG GKSTVIS++ER Y+P G + +D +++ LR+ + LVSQEPILF+ +IR N
Sbjct: 1071 ESGSGKSTVISMIERFYNPDSGKILIDQVEIQTFKLSWLRQQMGLVSQEPILFNETIRSN 1130
Query: 3332 IVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARAL 3511
I YG + G T E+I A AN H FI LP GY+T VGE+G QLSGGQKQRIAIARA+
Sbjct: 1131 IAYG-KTGGATEEEIIAAAKAANAHNFISSLPQGYDTSVGERGVQLSGGQKQRIAIARAI 1189
Query: 3512 IRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQ 3691
+++PKILLLDEATSALD ESE+ VQ ALD +RT +VVAHRL+TI NA I VVKNG
Sbjct: 1190 LKDPKILLLDEATSALDAESERVVQDALDRVMVNRTTVVVAHRLTTIKNADVIAVVKNGV 1249
Query: 3692 VVEQGTHNEL 3721
+ E+G H L
Sbjct: 1250 IAEKGRHETL 1259
Score = 381 bits (979), Expect = e-104
Identities = 215/532 (40%), Positives = 305/532 (56%), Gaps = 30/532 (5%)
Frame = +2
Query: 275 LKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYDKNTSGTLSNKL 454
L Y+ LG F + F + KL R R F V+ QEI+W+D + N +
Sbjct: 730 LIYIALGLTNFVMIPVPNYFFGIAGGKLIKRIRSMCFDKVVHQEISWFDDTANSRYYNFI 789
Query: 455 F---------------------DNLER--------VREGTGDKVGLAFQMMAQFIGGFAV 547
+ LER VR GD + L Q +A G +
Sbjct: 790 YIINRRILYVLILIFICVLLPPVRLERECSTDASTVRSLVGDALALIVQNIATVTTGLII 849
Query: 548 AFTYDWLLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIA 727
AFT +W+L LI+++LSPF++I G Y A +A + ++SIRTV +
Sbjct: 850 AFTANWILALIVLALSPFIVIQGYAQTKFLTGFSADAKAMYEEASQVANDAVSSIRTVAS 909
Query: 728 FNGQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRL 907
F +E Y+ + KK G++ L GAG F +Y C+ F G + G+
Sbjct: 910 FCAEEKVMDLYQQKCDGPKKNGVRLGLLSGAGFGFSFFFLYCINCVCFVSGAGLIQIGKA 969
Query: 908 ESGTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPS 1087
G V VFF++ + ++ + Q A +AAS+++++D P+ID+ S EG T
Sbjct: 970 TFGEVFKVFFALTIMAIGVSQTSAMAPDSNKAKDSAASIFDILDSTPKIDSSSDEGTTLQ 1029
Query: 1088 KISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNP 1267
++G I V F YP R DV+I + + L G+TVALVG SG GKST+I +++RFYNP
Sbjct: 1030 NVNGDIEFRHVSFRYPMRPDVQIFRDLCLTIPSGKTVALVGESGSGKSTVISMIERFYNP 1089
Query: 1268 DAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRS-DVSDEDIARALK 1444
D+G+ILID + I+ F + +LRQ +G+VSQEP LFN +I NI YG++ ++E+I A K
Sbjct: 1090 DSGKILIDQVEIQTFKLSWLRQQMGLVSQEPILFNETIRSNIAYGKTGGATEEEIIAAAK 1149
Query: 1445 EANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAES 1624
ANA +FI + P+G +T VG+RGVQ+SGGQKQRIAIARA++++PKILLLDEATSALDAES
Sbjct: 1150 AANAHNFISSLPQGYDTSVGERGVQLSGGQKQRIAIARAILKDPKILLLDEATSALDAES 1209
Query: 1625 ESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIE 1780
E +VQ AL+ RTT+V+AHRL+T++NAD I V+K G + E G HETL E
Sbjct: 1210 ERVVQDALDRVMVNRTTVVVAHRLTTIKNADVIAVVKNGVIAEKGRHETLDE 1261
Score = 365 bits (937), Expect = 5e-99
Identities = 224/591 (37%), Positives = 326/591 (54%), Gaps = 3/591 (0%)
Frame = +2
Query: 2012 GAVKANLFKILRYA-RPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKK 2188
G K + FK+ +A + + + G P +L F Q+IN F D D M +
Sbjct: 12 GNQKVSFFKLFSFADKTDVVLMTVGTIAAAGNGLTQPFMTLIFGQLINAFGTTDPDHMVR 71
Query: 2189 DGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHS 2368
+ A+ F+ LA Q S + V ER + IR + +LRQD YFD ++
Sbjct: 72 EVWKVAVKFIYLAVYSCVVAFLQVSCWMVTGERQSATIRGLYLKTILRQDIGYFDTETNT 131
Query: 2369 PGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAV 2548
G + R++ D I+ A+ ++G + + GG IAFY G +A ++ + P + +
Sbjct: 132 -GEVIGRMSGDTILIQDAMGEKVGKFTQLLCTFLGGFAIAFYKGPLLAGVLCSCIPLIVI 190
Query: 2549 GQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGG 2728
A M A AG + + IRTV A T + + + S L+ +
Sbjct: 191 AGAAMSLIMSKMAGRGQVAYAEAGNVVEQTVGAIRTVVAFTGEKQATEKYESKLEIAYKT 250
Query: 2729 NISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTI 2908
+ + +I G G ++ F +Y A +G LI +K V+ V+FA+ ++
Sbjct: 251 VVQQGLISGFGLGTMLAVIFCSYGLAVWYGAKLIMEKGY--NGGQVINVIFAVLTGGMSL 308
Query: 2909 GFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKLNKVFFRYPERP 3085
G + + AA +F ++ P+ID SG+ + + G+++L V+FRYP RP
Sbjct: 309 GQTSPSLNAFAAGRAAAFKMFETIKRSPKIDAYDMSGSVLEDIRGDIELKDVYFRYPARP 368
Query: 3086 AVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKH 3265
V I G ++ V G+T+ALVG SG GKSTVISL+ER YDP G V +DN DL+++ K
Sbjct: 369 DVQIFAGFSLFVPNGKTVALVGQSGSGKSTVISLIERFYDPESGQVLIDNIDLKKLQLKW 428
Query: 3266 LRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETR 3445
+R I LVSQEP+LF T+I+ENI YG + + T ++I TA AN KFID+LP G +T
Sbjct: 429 IRSKIGLVSQEPVLFATTIKENIAYGKE--DATDQEIRTAIELANAAKFIDKLPQGLDTM 486
Query: 3446 VGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCI 3625
VGE GTQ+SGGQKQR+AIARA+++NPKILLLDEATSALD ESE+ VQ AL +RT +
Sbjct: 487 VGEHGTQMSGGQKQRLAIARAILKNPKILLLDEATSALDAESERIVQDALVNLMSNRTTV 546
Query: 3626 VVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIA-KRGAYFALTQKQSSNQ 3775
VVAHRL+TI A I VV G++VE+GTH+E+I GAY L + Q ++
Sbjct: 547 VVAHRLTTIRTADVIAVVHQGKIVEKGTHDEMIQDPEGAYSQLVRLQEGSK 597
>gi|422285|pir||S30327 multidrug resistance protein 1 - Entamoeba
histolytica
gi|158971|gb|AAA29112.1| P-glycoprotein-1
Length = 1302
Score = 804 bits (2076), Expect = 0.0
Identities = 467/1274 (36%), Positives = 706/1274 (54%), Gaps = 33/1274 (2%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
++I +L+RY + ++L +GII S G PL+ I+ G+V FV + S
Sbjct: 33 VNIKELFRYAGVFEIILLIIGIIGSIGVGCLNPLLMILTGDVVDTFVNGENFSKEGGSIK 92
Query: 221 SEKAAARAEFSHEVIQNC----LKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFH 388
E + + LK +Y G AGFLQ CF V+ E + R +F
Sbjct: 93 ITTEEMNYEIMNSISDTINKLVLKMLYFAIGNMVAGFLQTICFFVLSEYQGIKIRSLYFK 152
Query: 389 SVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWL 568
+++RQ+ W+D + +G L++K+ ++++++++G K G FQ + FI G+ + F W
Sbjct: 153 ALLRQDPGWFDCHKTGELTSKIINDIQKIQDGMSLKFGRLFQTFSSFITGYLIGFIKCWD 212
Query: 569 LTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYE 748
LTL+++ + PF+M+ + ++ A IAE+ + +IRTV + +
Sbjct: 213 LTLVVLCMFPFIMVSMMGLGMSAGIFTMKSHKPFSEACSIAEQTIGNIRTVHSLTQERSF 272
Query: 749 CKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGR-----LES 913
C+ Y + K IKKS IG GL I +S L W G NFV G+ +++
Sbjct: 273 CESYNTKIMETDKYNIKKSIGIGTGLGCMMFFIMSSNALGSWYG-NFVVRGKGGSDNVKA 331
Query: 914 GTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKI 1093
GTVLTVF SV++ + +L Q + +A AA ++Y+ IDRIP+ID S G+ P++
Sbjct: 332 GTVLTVFMSVLLATQSLSQISTPINILNSAKVAAFNVYQTIDRIPDIDCQSIGGECPTEC 391
Query: 1094 SGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDA 1273
+G I V+F YPTR +LKG+ L+ + GQT+ALVG+SGCGKST IQL+QR Y+P+
Sbjct: 392 NGNIRFEDVQFVYPTRLSHHVLKGLDLEIKKGQTIALVGASGCGKSTTIQLIQRNYDPNG 451
Query: 1274 GQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSD---VSDEDIARALK 1444
G++ +D I + NIK+LR +G+V QEP LF +I +NI G + S+E++ K
Sbjct: 452 GRVTLDGKDIRELNIKWLRNQIGLVGQEPVLFAGTIRENIMLGAKEGATPSEEEMIECAK 511
Query: 1445 EANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAES 1624
ANA DFI PEG +T++G++G +SGGQKQRIAIARAL+RNP ILLLDEATSALD +S
Sbjct: 512 MANAHDFISKLPEGYDTIIGEKGALLSGGQKQRIAIARALIRNPSILLLDEATSALDTQS 571
Query: 1625 ESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHEL 1804
E IVQ ALE AS+GRTTI++AHRL+TVRNADKI V G+++E G H+ L++ KG Y+ L
Sbjct: 572 EKIVQEALEKASKGRTTIIVAHRLTTVRNADKICVFHQGEIIEQGKHQELMDLKGTYYGL 631
Query: 1805 VHAQVFADVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXX 1984
V Q + D+ + ++ Q + +++ + +
Sbjct: 632 VKRQSMEEEVDQETVENDLKKFREQEDKEVENISLEQTNLHNENSIVKQIKQEYKEEQKK 691
Query: 1985 XXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSN 2164
V N +K E+I+ + GA P +SL F +I V
Sbjct: 692 LKHSNRFVLFRVIWNNYK------HEYIFCTLGLIGGIGAGAAFPFYSLNFVDLIRVLMK 745
Query: 2165 PD-----RDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVL 2329
D+ ++ + + + S LF A E++ RIR + Y +++
Sbjct: 746 LHPGINLTDEQANSILRSCMIIICIGIITMISFFCYVGLFMAAGEKMIGRIRRRFYYSIM 805
Query: 2330 RQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQM 2509
Q+ ++FD ++ G +TT+L +D +++ R+G I +++VG G GI Y+ W++
Sbjct: 806 HQNVSWFDRRENMVGAVTTKLTSDPTSLQGISAERVGDIIEIMSTVGFGFGIGLYFSWKL 865
Query: 2510 AFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLY 2689
+ ++A+FP ++ + + + +A E G T +E +E ++T Q+L +
Sbjct: 866 SLCILAVFPIISFFMFINGQLNSKNAAPAKAAYEQCGVTLVEVVEAMKTAQSLGKEDYFS 925
Query: 2690 NIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVL 2869
+ + L P G I + +T N + F A + G + F K + ++V
Sbjct: 926 QKYNNDLQIPKRGIIKWGPLLSITNAITNLLTFSINAYGYYLG--ICFMKKTINYQQDVP 983
Query: 2870 RVLFAISFSFG-------TIGFAASYF-------PEYIKATFAAGLIFNMLEEEPRIDGM 3007
+ I +FG TI A + F P+ KA AA I+N+++ +P ID
Sbjct: 984 NFVDEIIDTFGDIQKALMTINSATTSFAQIGNVLPDVGKAVGAAKSIYNIIDRKPSIDCY 1043
Query: 3008 TSSG-TYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVIS 3184
+ G T+ + GE++ + FRYP R +L+G++ + G+T+ALVG SGCGKST I
Sbjct: 1044 SEEGETFNDVKGEIEFKNIHFRYPTRADNEVLKGISFKAEQGKTIALVGASGCGKSTTIQ 1103
Query: 3185 LLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPG-EY 3361
L+ER YDP G V +D ++++ +N LR I LV QEP+LF S+ +NI G+ G E
Sbjct: 1104 LIERFYDPTSGEVLLDGHNIKDLNIHFLRNQIGLVGQEPVLFAESVIDNIKRGVPEGVEV 1163
Query: 3362 THEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLD 3541
++EQI A AN H FI +P+GY T VG++G+QLSGGQKQRIAIARALIRNPK+LLLD
Sbjct: 1164 SNEQIYAAAKMANAHDFISAMPEGYNTMVGDRGSQLSGGQKQRIAIARALIRNPKVLLLD 1223
Query: 3542 EATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNEL 3721
EATSALD+ESEK VQ ALD A+K RT IV+AHRLSTI NA I V+ G++VEQG H EL
Sbjct: 1224 EATSALDSESEKIVQDALDKASKGRTTIVIAHRLSTIQNADKIYVIMRGKIVEQGKHQEL 1283
Query: 3722 IAKRGAYFALTQKQ 3763
I +G Y+ L +Q
Sbjct: 1284 IDLKGFYYTLAMQQ 1297
Score = 336 bits (861), Expect = 3e-90
Identities = 204/527 (38%), Positives = 294/527 (55%), Gaps = 4/527 (0%)
Frame = +2
Query: 2207 LMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITT 2386
L L A + Q F V +E ++IRS ++ +LRQD +FD H G +T+
Sbjct: 115 LKMLYFAIGNMVAGFLQTICFFVLSEYQGIKIRSLYFKALLRQDPGWFDC--HKTGELTS 172
Query: 2387 RLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMM 2566
++ D I+ + + G +F +S G I F W + +V+ +FPF+ V +
Sbjct: 173 KIINDIQKIQDGMSLKFGRLFQTFSSFITGYLIGFIKCWDLTLVVLCMFPFIMVSMMGLG 232
Query: 2567 KYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAI 2746
G K A A + I NIRTV +LT + + + + NI K+I
Sbjct: 233 MSAGIFTMKSHKPFSEACSIAEQTIGNIRTVHSLTQERSFCESYNTKIMETDKYNIKKSI 292
Query: 2747 IRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVL--MEPENVLRVLFAISFSFGTIGFAA 2920
G G + A +G F++ K ++ VL V ++ + ++ +
Sbjct: 293 GIGTGLGCMMFFIMSSNALGSWYGNFVVRGKGGSDNVKAGTVLTVFMSVLLATQSLSQIS 352
Query: 2921 SYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYP-QLSGEVKLNKVFFRYPERPAVPI 3097
+ A AA ++ ++ P ID + G P + +G ++ V F YP R + +
Sbjct: 353 TPINILNSAKVAAFNVYQTIDRIPDIDCQSIGGECPTECNGNIRFEDVQFVYPTRLSHHV 412
Query: 3098 LQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKH 3277
L+GL++ +K GQT+ALVG SGCGKST I L++R YDP G VT+D D+R++N K LR
Sbjct: 413 LKGLDLEIKKGQTIALVGASGCGKSTTIQLIQRNYDPNGGRVTLDGKDIRELNIKWLRNQ 472
Query: 3278 IALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSK-ANIHKFIDELPDGYETRVGE 3454
I LV QEP+LF +IRENI+ G + G E+ C+K AN H FI +LP+GY+T +GE
Sbjct: 473 IGLVGQEPVLFAGTIRENIMLGAKEGATPSEEEMIECAKMANAHDFISKLPEGYDTIIGE 532
Query: 3455 KGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVA 3634
KG LSGGQKQRIAIARALIRNP ILLLDEATSALDT+SEK VQ AL+ A+K RT I+VA
Sbjct: 533 KGALLSGGQKQRIAIARALIRNPSILLLDEATSALDTQSEKIVQEALEKASKGRTTIIVA 592
Query: 3635 HRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSSNQ 3775
HRL+T+ NA I V G+++EQG H EL+ +G Y+ L ++QS +
Sbjct: 593 HRLTTVRNADKICVFHQGEIIEQGKHQELMDLKGTYYGLVKRQSMEE 639
>gi|22328760|ref|NP_193539.2| ABC transporter family protein
[Arabidopsis thaliana]
Length = 1281
Score = 803 bits (2073), Expect = 0.0
Identities = 472/1243 (37%), Positives = 691/1243 (54%), Gaps = 16/1243 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+S F+L+ + D +++ VG I + G+ P M++I G + F T DP+
Sbjct: 16 VSFFKLFSFADKTDVVLMTVGTIAAAGNGLTQPFMTLIFGQLINAFGTT-----DPDHMV 70
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
EV + +K++YL FLQ SC+MV E+ S R + +++R
Sbjct: 71 -----------REVWKVAVKFIYLAVYSCVVAFLQVSCWMVTGERQSATIRGLYLKTILR 119
Query: 401 QEIAWYDKNTS-GTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
Q+I ++D T+ G + ++ + +++ G+KVG Q++ F+GGFA+AF LL
Sbjct: 120 QDIGYFDTETNTGEVIGRMSGDTILIQDAMGEKVGKFTQLLCTFLGGFAIAFYKGPLLAG 179
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
++ S P ++I G YA AG + E+ + +IRTV+AF G++ ++
Sbjct: 180 VLCSCIPLIVIAGAAMSLIMSKMAGRGQVAYAEAGNVVEQTVGAIRTVVAFTGEKQATEK 239
Query: 758 YEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFF 937
YE LE KT +++ + G GL + +I+ SY LA W G + G V+ V F
Sbjct: 240 YESKLEIAYKTVVQQGLISGFGLGTMLAVIFCSYGLAVWYGAKLIMEKGYNGGQVINVIF 299
Query: 938 SVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNK 1117
+V+ G M+LGQ AA ++E I R P+IDAY G I G I +
Sbjct: 300 AVLTGGMSLGQTSPSLNAFAAGRAAAFKMFETIKRSPKIDAYDMSGSVLEDIRGDIELKD 359
Query: 1118 VEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDI 1297
V F YP R DV+I G SL G+TVALVG SG GKST+I L++RFY+P++GQ+LID+I
Sbjct: 360 VYFRYPARPDVQIFAGFSLFVPNGKTVALVGQSGSGKSTVISLIERFYDPESGQVLIDNI 419
Query: 1298 PIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTF 1477
++ +K++R +G+VSQEP LF T+I++NI YG+ D +D++I A++ ANAA FI
Sbjct: 420 DLKKLQLKWIRSKIGLVSQEPVLFATTIKENIAYGKEDATDQEIRTAIELANAAKFIDKL 479
Query: 1478 PEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENA 1657
P+GL+T+VG+ G QMSGGQKQR+AIARA+++NPKILLLDEATSALDAESE IVQ AL N
Sbjct: 480 PQGLDTMVGEHGTQMSGGQKQRLAIARAILKNPKILLLDEATSALDAESERIVQDALVNL 539
Query: 1658 SRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQ-KGLYHELVHAQVFADVD 1834
RTT+V+AHRL+T+R AD I V+ G+++E GTH+ +I+ +G Y +LV Q
Sbjct: 540 MSNRTTVVVAHRLTTIRTADVIAVVHQGKIVEKGTHDEMIQDPEGAYSQLVRLQ----EG 595
Query: 1835 DKPKKKEAERRMSRQTSQRKGSVNFKT-QESQVDXXXXXXXXXXXXXXXXXXXXXXXXXX 2011
K + E+ER + +R GS+ + V
Sbjct: 596 SKEEATESERPETSLDVERSGSLRLSSAMRRSVSRNSSSSRHSFSLASNMFFPGVNVNQT 655
Query: 2012 GAV----------KANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFS 2161
+ K +L ++ +PE ++ G V P F L S IN+F
Sbjct: 656 DEMEDEENNVRHKKVSLKRLAHLNKPEIPVLVLGSIAAMVHGTVFPIFGLLLSSSINMFY 715
Query: 2162 NPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDA 2341
P + +KKD HFWAL+++ L + FG+A +L RIRS + V+ Q+
Sbjct: 716 EPAK-ILKKDSHFWALIYIALGLTNFVMIPVPNYFFGIAGGKLIKRIRSMCFDKVVHQEI 774
Query: 2342 TYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLV 2521
++FD D N +S + L I IA+V GL IAF W +A +V
Sbjct: 775 SWFD---------------DTANSRSLVGDALALIVQNIATVTTGLIIAFTANWILALIV 819
Query: 2522 MAIFPFMAVGQALMMKYHGGSATSDAKEM-ENAGKTAMEAIENIRTVQALTLQTKLYNIF 2698
+A+ PF+ + K+ G ++DAK M E A + A +A+ +IRTV + + K+ +++
Sbjct: 820 LALSPFIVIQGYAQTKFLTG-FSADAKAMYEEASQVANDAVSSIRTVASFCAEEKVMDLY 878
Query: 2699 CSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLI-FDKNVLMEPENVLRV 2875
D P + ++ G +GF+ + F G LI K E V +V
Sbjct: 879 QQKCDGPKKNGVRLGLLSGAGFGFSFFFLYCINCVCFVSGAGLIQIGKATFGE---VFKV 935
Query: 2876 LFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKL 3052
FA++ + ++ P+ KA +A IF++L+ P+ID + GT Q ++G+++
Sbjct: 936 FFALTIMAIGVSQTSAMAPDSNKAKDSAASIFDILDSTPKIDSSSDEGTTLQNVNGDIEF 995
Query: 3053 NKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVD 3232
V FRYP RP V I + L + + G+T+ALVG SG GKSTVIS++ER Y+P G + +D
Sbjct: 996 RHVSFRYPMRPDVQIFRDLCLTIPSGKTVALVGESGSGKSTVISMIERFYNPDSGKILID 1055
Query: 3233 NNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKF 3412
+++ LR+ + LVSQEPILF+ +IR NI YG + G T E+I A AN H F
Sbjct: 1056 QVEIQTFKLSWLRQQMGLVSQEPILFNETIRSNIAYG-KTGGATEEEIIAAAKAANAHNF 1114
Query: 3413 IDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVA 3592
I LP GY+T VGE+G QLSGGQKQRIAIARA++++PKILLLDEATSALD ESE+ VQ A
Sbjct: 1115 ISSLPQGYDTSVGERGVQLSGGQKQRIAIARAILKDPKILLLDEATSALDAESERVVQDA 1174
Query: 3593 LDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNEL 3721
LD +RT +VVAHRL+TI NA I VVKNG + E+G H L
Sbjct: 1175 LDRVMVNRTTVVVAHRLTTIKNADVIAVVKNGVIAEKGRHETL 1217
Score = 384 bits (987), Expect = e-105
Identities = 210/503 (41%), Positives = 298/503 (58%), Gaps = 1/503 (0%)
Frame = +2
Query: 275 LKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYDKNTSGTLSNKL 454
L Y+ LG F + F + KL R R F V+ QEI+W+D +
Sbjct: 730 LIYIALGLTNFVMIPVPNYFFGIAGGKLIKRIRSMCFDKVVHQEISWFDDTANS------ 783
Query: 455 FDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXXXX 634
R GD + L Q +A G +AFT +W+L LI+++LSPF++I G
Sbjct: 784 -------RSLVGDALALIVQNIATVTTGLIIAFTANWILALIVLALSPFIVIQGYAQTKF 836
Query: 635 XXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFLI 814
Y A +A + ++SIRTV +F +E Y+ + KK G++ L
Sbjct: 837 LTGFSADAKAMYEEASQVANDAVSSIRTVASFCAEEKVMDLYQQKCDGPKKNGVRLGLLS 896
Query: 815 GAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQFATI 994
GAG F +Y C+ F G + G+ G V VFF++ + ++ + Q
Sbjct: 897 GAGFGFSFFFLYCINCVCFVSGAGLIQIGKATFGEVFKVFFALTIMAIGVSQTSAMAPDS 956
Query: 995 GTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKGVSL 1174
A +AAS+++++D P+ID+ S EG T ++G I V F YP R DV+I + + L
Sbjct: 957 NKAKDSAASIFDILDSTPKIDSSSDEGTTLQNVNGDIEFRHVSFRYPMRPDVQIFRDLCL 1016
Query: 1175 DAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQ 1354
G+TVALVG SG GKST+I +++RFYNPD+G+ILID + I+ F + +LRQ +G+VSQ
Sbjct: 1017 TIPSGKTVALVGESGSGKSTVISMIERFYNPDSGKILIDQVEIQTFKLSWLRQQMGLVSQ 1076
Query: 1355 EPNLFNTSIEQNIRYGRS-DVSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQMSGG 1531
EP LFN +I NI YG++ ++E+I A K ANA +FI + P+G +T VG+RGVQ+SGG
Sbjct: 1077 EPILFNETIRSNIAYGKTGGATEEEIIAAAKAANAHNFISSLPQGYDTSVGERGVQLSGG 1136
Query: 1532 QKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLSTVRN 1711
QKQRIAIARA++++PKILLLDEATSALDAESE +VQ AL+ RTT+V+AHRL+T++N
Sbjct: 1137 QKQRIAIARAILKDPKILLLDEATSALDAESERVVQDALDRVMVNRTTVVVAHRLTTIKN 1196
Query: 1712 ADKIIVMKAGQVMEVGTHETLIE 1780
AD I V+K G + E G HETL E
Sbjct: 1197 ADVIAVVKNGVIAEKGRHETLDE 1219
Score = 365 bits (937), Expect = 5e-99
Identities = 224/591 (37%), Positives = 326/591 (54%), Gaps = 3/591 (0%)
Frame = +2
Query: 2012 GAVKANLFKILRYA-RPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKK 2188
G K + FK+ +A + + + G P +L F Q+IN F D D M +
Sbjct: 12 GNQKVSFFKLFSFADKTDVVLMTVGTIAAAGNGLTQPFMTLIFGQLINAFGTTDPDHMVR 71
Query: 2189 DGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHS 2368
+ A+ F+ LA Q S + V ER + IR + +LRQD YFD ++
Sbjct: 72 EVWKVAVKFIYLAVYSCVVAFLQVSCWMVTGERQSATIRGLYLKTILRQDIGYFDTETNT 131
Query: 2369 PGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAV 2548
G + R++ D I+ A+ ++G + + GG IAFY G +A ++ + P + +
Sbjct: 132 -GEVIGRMSGDTILIQDAMGEKVGKFTQLLCTFLGGFAIAFYKGPLLAGVLCSCIPLIVI 190
Query: 2549 GQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGG 2728
A M A AG + + IRTV A T + + + S L+ +
Sbjct: 191 AGAAMSLIMSKMAGRGQVAYAEAGNVVEQTVGAIRTVVAFTGEKQATEKYESKLEIAYKT 250
Query: 2729 NISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTI 2908
+ + +I G G ++ F +Y A +G LI +K V+ V+FA+ ++
Sbjct: 251 VVQQGLISGFGLGTMLAVIFCSYGLAVWYGAKLIMEKGY--NGGQVINVIFAVLTGGMSL 308
Query: 2909 GFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKLNKVFFRYPERP 3085
G + + AA +F ++ P+ID SG+ + + G+++L V+FRYP RP
Sbjct: 309 GQTSPSLNAFAAGRAAAFKMFETIKRSPKIDAYDMSGSVLEDIRGDIELKDVYFRYPARP 368
Query: 3086 AVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKH 3265
V I G ++ V G+T+ALVG SG GKSTVISL+ER YDP G V +DN DL+++ K
Sbjct: 369 DVQIFAGFSLFVPNGKTVALVGQSGSGKSTVISLIERFYDPESGQVLIDNIDLKKLQLKW 428
Query: 3266 LRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETR 3445
+R I LVSQEP+LF T+I+ENI YG + + T ++I TA AN KFID+LP G +T
Sbjct: 429 IRSKIGLVSQEPVLFATTIKENIAYGKE--DATDQEIRTAIELANAAKFIDKLPQGLDTM 486
Query: 3446 VGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCI 3625
VGE GTQ+SGGQKQR+AIARA+++NPKILLLDEATSALD ESE+ VQ AL +RT +
Sbjct: 487 VGEHGTQMSGGQKQRLAIARAILKNPKILLLDEATSALDAESERIVQDALVNLMSNRTTV 546
Query: 3626 VVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIA-KRGAYFALTQKQSSNQ 3775
VVAHRL+TI A I VV G++VE+GTH+E+I GAY L + Q ++
Sbjct: 547 VVAHRLTTIRTADVIAVVHQGKIVEKGTHDEMIQDPEGAYSQLVRLQEGSK 597
>gi|49089458|ref|XP_406437.1| hypothetical protein AN2300.2
[Aspergillus nidulans FGSC A4]
gi|40745255|gb|EAA64411.1| hypothetical protein AN2300.2 [Aspergillus
nidulans FGSC A4]
Length = 1343
Score = 800 bits (2065), Expect = 0.0
Identities = 464/1261 (36%), Positives = 694/1261 (54%), Gaps = 19/1261 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
IS F L+RY + +D L++ + I + A G LPL + + + L I D
Sbjct: 100 ISFFGLWRYATKMDILIMVISTICAIAAGAALPLFT---APSTFQRIMLYQISYD----- 151
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
EF E+ +N L +VYLG G F ++ F+ E + + R + S++R
Sbjct: 152 --------EFYDELTKNVLYFVYLGIGEFVTVYVSTVGFIYTGEHATQKIREYYLESILR 203
Query: 401 QEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLI 580
Q I ++DK +G ++ ++ + +++G +KVGL +A F+ F +A+ W L LI
Sbjct: 204 QNIGYFDKLGAGEVTTRITADTNLIQDGISEKVGLTLTALATFVTAFIIAYVKYWKLALI 263
Query: 581 MMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRY 760
S +++ Y G +AEEV++SIR AF Q+ K+Y
Sbjct: 264 CSSTIVALVLTMGGGSQFIIKYSKKSLDSYGAGGTVAEEVISSIRNATAFGTQDKLAKQY 323
Query: 761 EDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFS 940
E L+ +K G K ++G + + F ++Y++Y L FW+G+ F+ G ++ G +LTV +
Sbjct: 324 EVHLDEAEKWGTKNQIVMGFMIGAMFGLMYSNYGLGFWMGSRFLVDGAVDVGDILTVLMA 383
Query: 941 VMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKV 1120
+++GS +LG A+ AAA ++ IDR +D YS EG+T G I + V
Sbjct: 384 ILIGSFSLGNVSPNAQAFTNAVAAAAKIFGTIDRQSPLDPYSNEGKTLDHFEGHIELRNV 443
Query: 1121 EFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIP 1300
+ YP+R +V +++ VSL G+T ALVG SG GKST++ L++RFY P G +L+D
Sbjct: 444 KHIYPSRPEVTVMEDVSLSMPAGKTTALVGPSGSGKSTVVGLVERFYMPVRGTVLLDGHD 503
Query: 1301 IEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYG---------RSDVSDEDIARALKEAN 1453
I+D N+++LRQ + +VSQEP LF T+I +NIR+G D E I A K AN
Sbjct: 504 IKDLNLRWLRQQISLVSQEPVLFGTTIYKNIRHGLIGTKYENESEDKVRELIENAAKMAN 563
Query: 1454 AADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESI 1633
A DFI PEG T VG RG +SGGQKQRIAIARA+V +PKILLLDEATSALD +SE +
Sbjct: 564 AHDFITALPEGYETNVGQRGFLLSGGQKQRIAIARAVVSDPKILLLDEATSALDTKSEGV 623
Query: 1634 VQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHA 1813
VQ+ALE A+ GRTTIVIAHRLST++ A I+V+ G++ E GTH+ L+++ G Y +LV A
Sbjct: 624 VQAALERAAEGRTTIVIAHRLSTIKTAHNIVVLVNGKIAEQGTHDELVDRGGAYRKLVEA 683
Query: 1814 QVFADVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXX 1993
Q + + ++A+ K + S +D
Sbjct: 684 QRINEQKEADALEDADAEDLTNADIAKIKTA-SSASSDLDGKPTTIDRTGTHKSVSSAIL 742
Query: 1994 XXXXXXGAVKANLFKILRYA----RPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFS 2161
K +L+ +L++ RPE Y ++ G P ++ +++ I+ S
Sbjct: 743 SKRPPETTPKYSLWTLLKFVASFNRPEIPYMLIGLVFSVLAGGGQPTQAVLYAKAISTLS 802
Query: 2162 NPDRD--QMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQ 2335
P+ +++ D FW+LMF V+ +Q + + F V +ERL R RS +R +LRQ
Sbjct: 803 LPESQYSKLRHDADFWSLMFFVVGIIQFITQSTNGAAFAVCSERLIRRARSTAFRTILRQ 862
Query: 2336 DATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAF 2515
D +FD ++S G +T+ L+T+ ++ LG+I ++G + IA GW++A
Sbjct: 863 DIAFFDKEENSTGALTSFLSTETKHLSGVSGVTLGTILMTSTTLGAAIIIALAIGWKLAL 922
Query: 2516 LVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNI 2695
+ +++ P + + E + A EA +IRTV +LT + ++ I
Sbjct: 923 VCISVVPVLLACGFYRFYMLAQFQSRSKLAYEGSANFACEATSSIRTVASLTRERDVWEI 982
Query: 2696 FCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRV 2875
+ + LDA ++ + L Y + ++ FF A F +G L+ ++ R
Sbjct: 983 YHAQLDAQGRTSLISVLRSSLLYASSQALVFFCVALGFWYGGTLLGHHEY-----DIFRF 1037
Query: 2876 LFAIS---FSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGE 3043
S F + G S+ P+ KA AA + + +P+ID + G + + GE
Sbjct: 1038 FVCFSEILFGAQSAGTVFSFAPDMGKAKNAAAEFRRLFDRKPQIDNWSEEGEKLETVEGE 1097
Query: 3044 VKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAV 3223
++ V FRYP RP P+L+GL++ VKPGQ +ALVGPSGCGKST I+LLER YD + G++
Sbjct: 1098 IEFRNVHFRYPTRPEQPVLRGLDLTVKPGQYVALVGPSGCGKSTTIALLERFYDAIAGSI 1157
Query: 3224 TVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANI 3403
VD D+ ++N R ++LVSQEP L+ +I+ENI+ G+ + E + AC ANI
Sbjct: 1158 LVDGKDISKLNINSYRSFLSLVSQEPTLYQGTIKENILLGIVEDDVPEEFLIKACKDANI 1217
Query: 3404 HKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQV 3583
+ FI LP+G+ T VG KG LSGGQKQR+AIARAL+R+PKILLLDEATSALD+ESEK V
Sbjct: 1218 YDFIMSLPEGFNTVVGSKGGMLSGGQKQRVAIARALLRDPKILLLDEATSALDSESEKVV 1277
Query: 3584 QVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQ 3763
Q ALDAAA+ RT I VAHRLSTI A I V G++VE GTH+EL+ K+G Y+ L Q
Sbjct: 1278 QAALDAAARGRTTIAVAHRLSTIQKADVIYVFDQGKIVESGTHSELVQKKGRYYELVNLQ 1337
Query: 3764 S 3766
S
Sbjct: 1338 S 1338
Score = 335 bits (859), Expect = 5e-90
Identities = 224/606 (36%), Positives = 324/606 (52%), Gaps = 20/606 (3%)
Frame = +2
Query: 2018 VKANLFKILRYA-RPEWIYXXXXXXXXLIQGAVMPAFSL--FFSQIINVFSNPDR--DQM 2182
V + F + RYA + + + + GA +P F+ F +I+ + D D++
Sbjct: 98 VNISFFGLWRYATKMDILIMVISTICAIAAGAALPLFTAPSTFQRIMLYQISYDEFYDEL 157
Query: 2183 KKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPK 2362
K+ L F+ L + ++ F E T +IR ++LRQ+ YFD K
Sbjct: 158 TKN----VLYFVYLGIGEFVTVYVSTVGFIYTGEHATQKIREYYLESILRQNIGYFD--K 211
Query: 2363 HSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFL----VMAI 2530
G +TTR+ D I+ I ++G A+A+ IA+ W++A + ++A+
Sbjct: 212 LGAGEVTTRITADTNLIQDGISEKVGLTLTALATFVTAFIIAYVKYWKLALICSSTIVAL 271
Query: 2531 FPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHL 2710
M G ++KY S S G A E I +IR A Q KL + HL
Sbjct: 272 VLTMGGGSQFIIKYSKKSLDSYGA----GGTVAEEVISSIRNATAFGTQDKLAKQYEVHL 327
Query: 2711 DAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAI- 2887
D I+ G G + + Y F G + D V + ++L VL AI
Sbjct: 328 DEAEKWGTKNQIVMGFMIGAMFGLMYSNYGLGFWMGSRFLVDGAV--DVGDILTVLMAIL 385
Query: 2888 --SFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSG-TYPQLSGEVKLNK 3058
SFS G + A F A AA IF ++ + +D ++ G T G ++L
Sbjct: 386 IGSFSLGNVSPNAQAFTN---AVAAAAKIFGTIDRQSPLDPYSNEGKTLDHFEGHIELRN 442
Query: 3059 VFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNN 3238
V YP RP V +++ +++ + G+T ALVGPSG GKSTV+ L+ER Y P+ G V +D +
Sbjct: 443 VKHIYPSRPEVTVMEDVSLSMPAGKTTALVGPSGSGKSTVVGLVERFYMPVRGTVLLDGH 502
Query: 3239 DLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQ-------IETACSKA 3397
D++ +N + LR+ I+LVSQEP+LF T+I +NI +GL +Y +E IE A A
Sbjct: 503 DIKDLNLRWLRQQISLVSQEPVLFGTTIYKNIRHGLIGTKYENESEDKVRELIENAAKMA 562
Query: 3398 NIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEK 3577
N H FI LP+GYET VG++G LSGGQKQRIAIARA++ +PKILLLDEATSALDT+SE
Sbjct: 563 NAHDFITALPEGYETNVGQRGFLLSGGQKQRIAIARAVVSDPKILLLDEATSALDTKSEG 622
Query: 3578 QVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQ 3757
VQ AL+ AA+ RT IV+AHRLSTI A I+V+ NG++ EQGTH+EL+ + GAY L +
Sbjct: 623 VVQAALERAAEGRTTIVIAHRLSTIKTAHNIVVLVNGKIAEQGTHDELVDRGGAYRKLVE 682
Query: 3758 KQSSNQ 3775
Q N+
Sbjct: 683 AQRINE 688
>gi|39595964|emb|CAE67467.1| Hypothetical protein CBG12969
[Caenorhabditis briggsae]
Length = 1231
Score = 798 bits (2060), Expect = 0.0
Identities = 448/1231 (36%), Positives = 685/1231 (55%), Gaps = 6/1231 (0%)
Frame = +2
Query: 5 SXXXXXXXXXXXISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVT 184
S S L RY++ VDRL+L +GI +S + G L +I+ F
Sbjct: 18 SSSSSESSSSNSFSYCSLLRYSNKVDRLLLGLGIFLSISQGCCSSLNAIL-------FRD 70
Query: 185 LGTIFLDPNSTASEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSN 364
L + + + + + +F++E + Y G +F+ F+ C+ CE+
Sbjct: 71 LTDVLISGQGSYTNQTFDHQQFNNETLNIIHTYFLYGTLLFSLSFVSMCCWHTFCERQIF 130
Query: 365 RFRRQFFHSVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFA 544
+ R +F +++RQ+ W+D+N SG ++ D LERVR+G GDK+G+ + F G +
Sbjct: 131 KIRVAYFSALLRQDWEWFDQNDSGAAIVRMNDGLERVRDGLGDKLGVIIAYLTHFFCGLS 190
Query: 545 VAFTYDWLLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVI 724
+AF +T++ + ++P ++ + Y A A EV++ I+TV+
Sbjct: 191 LAFYLSVEMTIVTLIITPAFILPIIISRKMISKVTFKELEAYESAATAAGEVISGIKTVV 250
Query: 725 AFNGQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCL------AFWVGTN 886
+FNG++ E RY L G+ + A L+SF ++ S C+ + W GT
Sbjct: 251 SFNGEQKEINRYSKFLSKAMYWGLWR-----ASLSSFEGLLGHSSCVFQWQFHSGWWGTR 305
Query: 887 FVYSGRLESGTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYS 1066
V G + GT L VF++V +GQA ++ + AA ++++IDR +D S
Sbjct: 306 LVLKGSITPGTTLAVFWAVNGAIYFVGQAIPHLTSVSSCYSAAVPVFQIIDRTVILDGTS 365
Query: 1067 TEGQTPSKISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQL 1246
+G SK+ G++ V F YP R V +LKG+SL A PG+ +ALVG SG GKST L
Sbjct: 366 DKGLKLSKVKGKVKFENVWFKYPARQKVNVLKGISLHANPGENIALVGHSGSGKSTTAAL 425
Query: 1247 LQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDED 1426
+ FY + G+I IDD I++ N+ +LR +VG+VSQEP LF ++E N+R G D+ D +
Sbjct: 426 MMHFYELNGGKISIDDTNIDELNLSHLRNIVGIVSQEPLLFADTVENNMRLGAPDLDDNE 485
Query: 1427 IARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATS 1606
+ K ANA DFI+ P G T +G+ GV++SGGQ+QRIAIAR L R P IL+LDEATS
Sbjct: 486 MEYYCKLANAHDFIEQLPNGYKTAIGNGGVELSGGQRQRIAIARTLARKPSILILDEATS 545
Query: 1607 ALDAESESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQK 1786
ALD+ESES+VQ ALENA+ GRTTI IAHRL T+RN ++I V G+++EVG+H+ L+E+
Sbjct: 546 ALDSESESLVQIALENAAEGRTTITIAHRLGTIRNCNRIYVFDDGKIVEVGSHQELMEKD 605
Query: 1787 GLYHELVHAQVFADVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXX 1966
G Y ++V +Q +++ +++ S ++ R+ S + K+ +
Sbjct: 606 GHYAKMVQSQ---EIEVGNRQESTMEEYSFES--RRESCDSKSSRQKFSKKTARSCSLTS 660
Query: 1967 XXXXXXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQI 2146
+ +ILRY +PEW +++G P +S+ + ++
Sbjct: 661 EKLLSDISPLPIGEENEQPSTFLEILRYTKPEWGLLAISILISVLRGFNYPIYSILYGRM 720
Query: 2147 INVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNV 2326
+ S ++ + A+ L + L G ERLT R+R ++ N+
Sbjct: 721 FRILSTGTDEEKSSNSGMNAIYLTALGIYALIVTMAAGCLIGYVGERLTKRLRILLFTNI 780
Query: 2327 LRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQ 2506
LRQD YFD+P+H+PGR+ TRL+TDAPNI++AID RL + ++V G+ IAF++
Sbjct: 781 LRQDGEYFDVPEHAPGRLITRLSTDAPNIRAAIDQRLADVIQGFSAVFCGIAIAFWFSPT 840
Query: 2507 MAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKL 2686
MA + + + Q + D++ E + A+EA+E RTVQ LT +
Sbjct: 841 MALMGLVNVGVLISLQGFITHVLKKRGEKDSERSEEPSRLAIEAVEQHRTVQYLTREQSF 900
Query: 2687 YNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENV 2866
F + H N+ + I++ ++Y + S F++A +RFGL L+ + L P V
Sbjct: 901 VKKFADGMHPIHIRNLQRGILQSISYALSTSYTSFSFAIGYRFGLLLV--DHDLANPFTV 958
Query: 2867 LRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEV 3046
+V+ +++ S ++ SY PE+++A +AGL+F ML EP+ID T T L ++
Sbjct: 959 FQVIESLNSSSPSLLALGSYIPEFVRAQISAGLLFQMLRYEPKIDSNTGKKT--TLDSDI 1016
Query: 3047 KLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVT 3226
L V+F Y IL+ + ++ G+T A+VG SGCGKST I LLER YDP+ G +
Sbjct: 1017 SLKNVYFGYQVSGRKMILKDFTLKIESGKTTAIVGASGCGKSTTIQLLERFYDPIAGRID 1076
Query: 3227 VDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIH 3406
+ +LR +N KHLR +ALV QEP LF+ SIR+NI YGL+ ++ A A+ H
Sbjct: 1077 FGSTNLRDLNLKHLRSQVALVEQEPTLFNYSIRKNIAYGLE--SIKEGEVIQAAKIAHAH 1134
Query: 3407 KFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQ 3586
+FI LP+GY+T VGE G++LSGGQKQRIAIARA++RNPKILLLDEA SALD ESE+ VQ
Sbjct: 1135 EFITSLPEGYDTIVGEGGSKLSGGQKQRIAIARAIVRNPKILLLDEAMSALDVESERLVQ 1194
Query: 3587 VALDAAAKDRTCIVVAHRLSTIVNAGCIMVV 3679
AL+ A + RTC+V+AHRL+TI A I++V
Sbjct: 1195 EALEKAKEGRTCVVIAHRLTTIRGALLILIV 1225
Score = 275 bits (702), Expect = 8e-72
Identities = 165/497 (33%), Positives = 267/497 (53%), Gaps = 3/497 (0%)
Frame = +2
Query: 2282 ERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIA 2461
ER +IR + +LRQD +FD ++ G R+ ++ + +LG I +
Sbjct: 126 ERQIFKIRVAYFSALLRQDWEWFD--QNDSGAAIVRMNDGLERVRDGLGDKLGVIIAYLT 183
Query: 2462 SVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAI 2641
GL +AFY +M + + I P + + K + + E+A A E I
Sbjct: 184 HFFCGLSLAFYLSVEMTIVTLIITPAFILPIIISRKMISKVTFKELEAYESAATAAGEVI 243
Query: 2642 ENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLT--YGFANSIQFFTYAAAFRF 2815
I+TV + + K N + L + +A + G ++ + + + + + +
Sbjct: 244 SGIKTVVSFNGEQKEINRYSKFLSKAMYWGLWRASLSSFEGLLGHSSCVFQWQFHSGW-W 302
Query: 2816 GLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPR 2995
G L+ ++ P L V +A++ + +G A + AA +F +++
Sbjct: 303 GTRLVLKGSIT--PGTTLAVFWAVNGAIYFVGQAIPHLTSVSSCYSAAVPVFQIIDRTVI 360
Query: 2996 IDGMTSSGT-YPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKS 3172
+DG + G ++ G+VK V+F+YP R V +L+G+++H PG+ +ALVG SG GKS
Sbjct: 361 LDGTSDKGLKLSKVKGKVKFENVWFKYPARQKVNVLKGISLHANPGENIALVGHSGSGKS 420
Query: 3173 TVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQP 3352
T +L+ Y+ G +++D+ ++ ++N HLR + +VSQEP+LF ++ N+ G
Sbjct: 421 TTAALMMHFYELNGGKISIDDTNIDELNLSHLRNIVGIVSQEPLLFADTVENNMRLGAP- 479
Query: 3353 GEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKIL 3532
+ ++E C AN H FI++LP+GY+T +G G +LSGGQ+QRIAIAR L R P IL
Sbjct: 480 -DLDDNEMEYYCKLANAHDFIEQLPNGYKTAIGNGGVELSGGQRQRIAIARTLARKPSIL 538
Query: 3533 LLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTH 3712
+LDEATSALD+ESE VQ+AL+ AA+ RT I +AHRL TI N I V +G++VE G+H
Sbjct: 539 ILDEATSALDSESESLVQIALENAAEGRTTITIAHRLGTIRNCNRIYVFDDGKIVEVGSH 598
Query: 3713 NELIAKRGAYFALTQKQ 3763
EL+ K G Y + Q Q
Sbjct: 599 QELMEKDGHYAKMVQSQ 615
>gi|22535563|dbj|BAC10738.1| putative multidrug resistance protein 1
homolog [Oryza sativa (japonica cultivar-group)]
gi|27368857|emb|CAD59586.1| MDR-like ABC transporter [Oryza sativa
(japonica cultivar-group)]
Length = 1274
Score = 796 bits (2056), Expect = 0.0
Identities = 454/1258 (36%), Positives = 698/1258 (55%), Gaps = 14/1258 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+S L+RY D L++AVG + + A GV PLM++I G V F
Sbjct: 37 VSFTGLFRYADGTDLLLMAVGTVAALANGVSQPLMTVIFGQVINAF-------------- 82
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
A + H V Q L +VYLG FLQ +C+ + E+ + R R + SV+R
Sbjct: 83 --GEATNGDVLHRVNQAVLNFVYLGIATAVVSFLQVACWTMTGERQATRIRSLYLKSVLR 140
Query: 401 QEIAWYD-KNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
Q+IA++D + T+G + +++ + V++ G+KVG Q++A F GGF VAF WLL+L
Sbjct: 141 QDIAFFDVEMTTGQIVSRMSGDTVLVQDAIGEKVGKFLQLVATFAGGFVVAFVKGWLLSL 200
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
+M++ P ++I G Y+ A + E+ + +I+TV++FNG++
Sbjct: 201 VMLACIPPVVIAGGAVSKMLAKISSKGQASYSDAANVVEQTIGAIKTVVSFNGEKQAVAS 260
Query: 758 YEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFF 937
Y + K +++ G G+ S F I ++SY LA W G V S G ++ + F
Sbjct: 261 YNKLINKAYKAAVEEGLTNGFGMGSVFFIFFSSYGLAIWYGGKLVVSKGYSGGDIINILF 320
Query: 938 SVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNK 1117
+VM G+M+LG A A AA L++ I R P+ID G+ I G + +
Sbjct: 321 AVMTGAMSLGNATPCMAAFAEGQSAAYRLFKTIKRKPQIDPDDITGKQLEDIRGDVELKD 380
Query: 1118 VEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDI 1297
V F+YP R + I G SL G T+A+VG SG GKST+I L++RFY+P AG++LID I
Sbjct: 381 VYFSYPARPEQLIFDGFSLHVSSGTTMAIVGESGSGKSTVISLVERFYDPQAGEVLIDGI 440
Query: 1298 PIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTF 1477
I+ + ++R +G+VSQEP LF TSI+ NI YG+ D + E+I RA + ANAA+FI
Sbjct: 441 NIKSLRLNWIRGKIGLVSQEPLLFMTSIKDNITYGKEDATIEEIRRAAELANAANFIDKL 500
Query: 1478 PEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENA 1657
P+G +T+VG RG Q+SGGQKQRIAIARA+++NPKILLLDEATSALD ESE IVQ AL
Sbjct: 501 PDGYDTMVGQRGAQLSGGQKQRIAIARAILKNPKILLLDEATSALDVESERIVQEALNRI 560
Query: 1658 SRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLI-EQKGLYHELVHAQVFADVD 1834
RTT+V+AHRL+TVRNAD I V++ G+++E G H+ L+ G+Y +L+ Q + +
Sbjct: 561 MVDRTTLVVAHRLTTVRNADCISVVQQGKIVEQGPHDELVMNPNGVYSQLIRLQETHEEE 620
Query: 1835 DK------PKKKEAERRMS-RQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXX 1993
+K + R +S +++ R + N +
Sbjct: 621 EKKLDHHISDSRSKSRSLSFKRSISRDSAGNSSRHSLALPFGLPGSVELLEGNDSTVGEQ 680
Query: 1994 XXXXXXGAV--KANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNP 2167
G V KA + ++ R +PE + G + P F + S I F P
Sbjct: 681 TEQGGDGEVQQKAPIGRLARLNKPEVPILLLATLAAGVHGVLFPMFGVMISNAIKTFFEP 740
Query: 2168 DRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATY 2347
D++KKD FW LM +VL + S+ + +FG+A +L R+R+ +R+++ Q+ +
Sbjct: 741 -ADKLKKDASFWGLMCVVLGIISIISIPVEYFMFGIAGGKLVERVRALSFRSIIHQEVAW 799
Query: 2348 FDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMA 2527
FD P++S G + RL+ DA N++ + L ++++ G+ IA W++ +++
Sbjct: 800 FDDPRNSSGALGARLSVDALNVRRLVGDNLALAVQVVSTLITGIVIAMIADWKLTLIILC 859
Query: 2528 IFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSH 2707
+ P + + +K+ G + E+A + A +A+ +IRTV + + ++ ++ +
Sbjct: 860 VIPLVGLQGYAQVKFLKGFSEDAKMLYEDASQVATDAVSSIRTVASFCSEKRVMTMYDNK 919
Query: 2708 LDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGL-FLIFDKNVLMEPENVLRVLFA 2884
+A + ++ GL +GF+ + + TY F G F+ +K +V +V FA
Sbjct: 920 CEASKNQGVRTGMVGGLGFGFSFLMLYLTYGLCFYVGAQFVRHNKTTF---GDVFKVFFA 976
Query: 2885 ISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSG-TYPQLSGEVKLNKV 3061
+ + I ++ + KA +A IF +L+ + +ID + G T + G + V
Sbjct: 977 LVLATIGISQTSAMASDSTKAKDSAISIFALLDRKSQIDSSSDEGRTLANVKGNIDFRHV 1036
Query: 3062 FFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNND 3241
F+YP RP V I +H+ G+T+ALVG SG GKST I+LLER Y+P G + +D +
Sbjct: 1037 SFKYPTRPDVQIFSDFTLHIPSGKTVALVGESGSGKSTAIALLERFYNPESGTILLDEVE 1096
Query: 3242 LRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDE 3421
++ + LR + LV QEP+LF+ +IR NI YG + G+ T E++ A +N H+FI
Sbjct: 1097 IKNLKVNWLRDQMGLVGQEPVLFNDTIRANIAYG-KHGDVTEEELIKAAKASNAHEFISS 1155
Query: 3422 LPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDA 3601
LP GY+T VGE+G QLSGGQKQR+AIARA++++PKILLLDEATSALD ESE+ VQ ALD
Sbjct: 1156 LPQGYDTTVGERGVQLSGGQKQRVAIARAILKDPKILLLDEATSALDAESERIVQDALDN 1215
Query: 3602 AAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELI-AKRGAYFALTQKQSSN 3772
RT I+VAHRLSTI A I V+K+G + E+G H L+ K G Y +L + +S +
Sbjct: 1216 VMVGRTTIIVAHRLSTIKGADIIAVLKDGAIAEKGRHEALMNIKDGVYASLVELRSGS 1273
Score = 353 bits (906), Expect = 2e-95
Identities = 208/588 (35%), Positives = 322/588 (54%), Gaps = 3/588 (0%)
Frame = +2
Query: 2021 KANLFKILRYAR-PEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGH 2197
K + + RYA + + L G P ++ F Q+IN F + +
Sbjct: 36 KVSFTGLFRYADGTDLLLMAVGTVAALANGVSQPLMTVIFGQVINAFGEATNGDVLHRVN 95
Query: 2198 FWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGR 2377
L F+ L Q + + + ER RIRS ++VLRQD +FD+ + + G+
Sbjct: 96 QAVLNFVYLGIATAVVSFLQVACWTMTGERQATRIRSLYLKSVLRQDIAFFDV-EMTTGQ 154
Query: 2378 ITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQA 2557
I +R++ D ++ AI ++G +A+ GG +AF GW ++ +++A P + +
Sbjct: 155 IVSRMSGDTVLVQDAIGEKVGKFLQLVATFAGGFVVAFVKGWLLSLVMLACIPPVVIAGG 214
Query: 2558 LMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNIS 2737
+ K ++ +A + I I+TV + + + + ++ + +
Sbjct: 215 AVSKMLAKISSKGQASYSDAANVVEQTIGAIKTVVSFNGEKQAVASYNKLINKAYKAAVE 274
Query: 2738 KAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFA 2917
+ + G G I F +Y A +G L+ K +++ +LFA+ ++G A
Sbjct: 275 EGLTNGFGMGSVFFIFFSSYGLAIWYGGKLVVSKGY--SGGDIINILFAVMTGAMSLGNA 332
Query: 2918 ASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKLNKVFFRYPERPAVP 3094
+ + AA +F ++ +P+ID +G + + G+V+L V+F YP RP
Sbjct: 333 TPCMAAFAEGQSAAYRLFKTIKRKPQIDPDDITGKQLEDIRGDVELKDVYFSYPARPEQL 392
Query: 3095 ILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRK 3274
I G ++HV G T+A+VG SG GKSTVISL+ER YDP G V +D +++ + +R
Sbjct: 393 IFDGFSLHVSSGTTMAIVGESGSGKSTVISLVERFYDPQAGEVLIDGINIKSLRLNWIRG 452
Query: 3275 HIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGE 3454
I LVSQEP+LF TSI++NI YG + + T E+I A AN FID+LPDGY+T VG+
Sbjct: 453 KIGLVSQEPLLFMTSIKDNITYGKE--DATIEEIRRAAELANAANFIDKLPDGYDTMVGQ 510
Query: 3455 KGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVA 3634
+G QLSGGQKQRIAIARA+++NPKILLLDEATSALD ESE+ VQ AL+ DRT +VVA
Sbjct: 511 RGAQLSGGQKQRIAIARAILKNPKILLLDEATSALDVESERIVQEALNRIMVDRTTLVVA 570
Query: 3635 HRLSTIVNAGCIMVVKNGQVVEQGTHNELIAK-RGAYFALTQKQSSNQ 3775
HRL+T+ NA CI VV+ G++VEQG H+EL+ G Y L + Q +++
Sbjct: 571 HRLTTVRNADCISVVQQGKIVEQGPHDELVMNPNGVYSQLIRLQETHE 618
>gi|15234323|ref|NP_192092.1| multidrug resistance P-glycoprotein,
putative [Arabidopsis thaliana]
gi|25297454|pir||E85023 probable P-glycoprotein-like protein
[imported] - Arabidopsis thaliana
gi|4558552|gb|AAD22645.1| putative P-glycoprotein-like protein
[Arabidopsis thaliana]
gi|7268567|emb|CAB80676.1| putative P-glycoprotein-like protein
[Arabidopsis thaliana]
Length = 1230
Score = 793 bits (2049), Expect = 0.0
Identities = 455/1239 (36%), Positives = 689/1239 (54%), Gaps = 3/1239 (0%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+ ++L+ ++ + D L++ VG I + A GV PLM+++ G + + PN
Sbjct: 13 VPFYKLFFFSDSTDVLLMIVGSIGAIANGVCSPLMTLLFGELIDA--------MGPNQN- 63
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
E V + CL VYLG G A FLQ +C+M+ E+ + R R + +++R
Sbjct: 64 ------NEEIVERVSKVCLSLVYLGLGALGAAFLQVACWMITGERQAARIRSLYLKTILR 117
Query: 401 QEIAWYD-KNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
Q+I ++D + T+G + ++ + + + G+KVG Q+++ F+GGF +AF WLLTL
Sbjct: 118 QDIGFFDVEMTTGEVVGRMSGDTVLILDAMGEKVGKFIQLISTFVGGFVIAFLRGWLLTL 177
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
+M++ P + + G YA A + E+ L SIRTV +F G++
Sbjct: 178 VMLTSIPLLAMSGAAIAIIVTRASSQEQAAYAKASNVVEQTLGSIRTVASFTGEKQAMSS 237
Query: 758 YEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFF 937
Y++ + K+ +K+ F+ G GL F++ +++Y L W G + G V+ V
Sbjct: 238 YKELINLAYKSNVKQGFVTGLGLGVMFLVFFSTYALGTWFGGEMILRKGYTGGAVINVMV 297
Query: 938 SVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNK 1117
+V+ S+ALGQA AA ++E I+R P ID + G+ I G I +
Sbjct: 298 TVVSSSIALGQASPCLTAFTAGKAAAYKMFETIEREPLIDTFDLNGKVLEDIRGEIELRD 357
Query: 1118 VEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDI 1297
V F+YP R ++ G SL G T ALVG SG GKST+I L++RFY+P++GQ+LID +
Sbjct: 358 VCFSYPARPKEEVFGGFSLLIPSGTTTALVGESGSGKSTVISLIERFYDPNSGQVLIDGV 417
Query: 1298 PIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTF 1477
+++F +K++R +G+VSQEP LF++SI +NI YG+ + E+I A K ANAA FI
Sbjct: 418 DLKEFQLKWIRGKIGLVSQEPVLFSSSIMENIGYGKEGATVEEIQAASKLANAAKFIDKL 477
Query: 1478 PEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENA 1657
P GL TLVG+ G Q+SGGQKQRIAIARA++++P+ILLLDEATSALDAESE +VQ AL+
Sbjct: 478 PLGLETLVGEHGTQLSGGQKQRIAIARAILKDPRILLLDEATSALDAESERVVQEALDRI 537
Query: 1658 SRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTH-ETLIEQKGLYHELVHAQVFADVD 1834
RTT+++AHRLSTVRNAD I V+ G+++E G+H E L + +G Y +L+ Q
Sbjct: 538 MVNRTTVIVAHRLSTVRNADIIAVIHRGKIVEEGSHSELLKDHEGAYSQLLRLQEI---- 593
Query: 1835 DKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXG 2014
KE++R S GS Q D
Sbjct: 594 ----NKESKRLEISDGSISSGSSRGNNSTRQDDDSFSVLGLLAGQDSTKMSQEL------ 643
Query: 2015 AVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDG 2194
+ K + +I +PE + G + P F + F+++I F ++K+D
Sbjct: 644 SQKVSFTRIAALNKPEIPILILGTLVGAVNGTIFPIFGILFAKVIEAFFKAPH-ELKRDS 702
Query: 2195 HFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPG 2374
FW+++F++L LF +A RL RIRS + V+ + +FD P +S G
Sbjct: 703 RFWSMIFVLLGVAAVIVYPTTNYLFAIAGGRLIRRIRSMCFEKVVHMEVGWFDEPGNSSG 762
Query: 2375 RITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQ 2554
+ RL+ DA I++ + L +AS+ GL IAF W++A +++ I PF+ +
Sbjct: 763 AMGARLSADAALIRTLVGDSLCLSVKNVASLVTGLIIAFTASWEVAIIILVIIPFIGING 822
Query: 2555 ALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNI 2734
+ +K+ G + + E A + A +A+ +IRTV + + K+ ++ + I
Sbjct: 823 YIQIKFMKGFSADAKAKYEEASQVANDAVGSIRTVASFCAEEKVMEMYKKRCEDTIKSGI 882
Query: 2735 SKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGF 2914
+ +I G+ +G + + + YA+ F G L+ K +V +V A++ + I
Sbjct: 883 KQGLISGVGFGISFFVLYSVYASCFYVGARLV--KAGRTNFNDVFQVFLALTLTAVGISQ 940
Query: 2915 AASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSG-TYPQLSGEVKLNKVFFRYPERPAV 3091
A+S+ P+ K AA IF +++ +ID SG + G+++L + F Y RP V
Sbjct: 941 ASSFAPDSSKGKGAAVSIFRIIDRISKIDSRDESGMVLENVKGDIELCHISFTYQTRPDV 1000
Query: 3092 PILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLR 3271
+ + L + ++ GQT+ALVG SG GKSTVISLL+R YDP G +T+D +L+++ K LR
Sbjct: 1001 QVFRDLCLSIRAGQTVALVGESGSGKSTVISLLQRFYDPDSGHITLDGVELKKLRLKWLR 1060
Query: 3272 KHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVG 3451
+ + LV QEP+LF+ +IR NI YG E T +I A AN H+FI + GY+T VG
Sbjct: 1061 QQMGLVGQEPVLFNDTIRANIAYGKGGEEATEAEIIAASELANAHRFISSIQKGYDTVVG 1120
Query: 3452 EKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVV 3631
E+G QLSGGQKQR+AIARA+++ PKILLLDEATSALD ESE+ VQ ALD +RT IVV
Sbjct: 1121 ERGIQLSGGQKQRVAIARAIVKEPKILLLDEATSALDAESERVVQDALDRVMVNRTTIVV 1180
Query: 3632 AHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFA 3748
AHRLSTI NA I VVKNG + E+GTH LI G +A
Sbjct: 1181 AHRLSTIKNADVIAVVKNGVIAEKGTHETLINIEGGVYA 1219
>gi|46390486|dbj|BAD15946.1| putative MDR-like ABC transporter [Oryza
sativa (japonica cultivar-group)]
gi|50252693|dbj|BAD28861.1| putative MDR-like ABC transporter [Oryza
sativa (japonica cultivar-group)]
Length = 1285
Score = 791 bits (2042), Expect = 0.0
Identities = 470/1279 (36%), Positives = 706/1279 (54%), Gaps = 39/1279 (3%)
Frame = +2
Query: 53 QLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKA 232
+L+ + +D ++AVG + + A GV +P ++ ++G + F A
Sbjct: 32 RLFTFADRLDAALMAVGGVAAVANGVAMPFLAFLIGELVDAF----------------GA 75
Query: 233 AARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIA 412
A RA H V + L++ Y+ G AGFLQ SC+MV E+ + R R + +++RQ+I
Sbjct: 76 ADRAHVVHVVSKISLRFTYVAIGSGIAGFLQVSCWMVTGERQAARIRGLYLEAILRQDIT 135
Query: 413 WYDKNTS-GTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMS 589
++D TS G ++ ++ + +++ G+KVG Q+++ F+GGF +AF WLL+L+M+S
Sbjct: 136 FFDLETSTGEVTERMSSDTVLIQDAIGEKVGKFLQLLSTFLGGFIIAFARGWLLSLVMLS 195
Query: 590 LSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDA 769
P + + YA AG + E+ + SIRTV++F G+ +Y +
Sbjct: 196 SIPPVALAAAAMSIAISKLANRSQLAYAEAGKLVEQTIGSIRTVVSFTGERRATDKYNEF 255
Query: 770 LEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMM 949
L+ ++ + + +G G+ S I++ SY LA W G + G ++ V ++M
Sbjct: 256 LKISYRSAVHQGAAMGLGIGSVMFIVFCSYGLAVWYGAKLIIEKGYTGGYIINVLMAIMS 315
Query: 950 GSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFT 1129
G+MALGQ+ + AA ++ I+R PEIDA G G + V F+
Sbjct: 316 GAMALGQSSPCLNAFASGQIAAYKMFATINREPEIDASDRSGLVLENFVGDVEFKDVHFS 375
Query: 1130 YPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIED 1309
YP R + I G S+ G T+ALVG SG GKST+I L++RFY+P +G++L+D + ++
Sbjct: 376 YPARPEQLIFTGFSISIPSGMTMALVGESGSGKSTVISLVERFYDPQSGEVLLDGVNMKL 435
Query: 1310 FNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEGL 1489
N+ +RQ +G+VSQEP LF T+I +NI YG+ D S+E+I RA+ ANAA FI P GL
Sbjct: 436 LNLSRIRQKIGLVSQEPILFTTTIRENIEYGKKDASEEEIRRAIVLANAAKFIDKLPNGL 495
Query: 1490 NTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGR 1669
+T+VG+ G Q+SGGQKQRIAIARA++++P+ILLLDEATSALDAESE +VQ AL N R
Sbjct: 496 DTMVGEHGTQLSGGQKQRIAIARAILKDPRILLLDEATSALDAESEHVVQDALNNIMVNR 555
Query: 1670 TTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIE-QKGLYHELVHAQV--------- 1819
TTI++AHRLSTVRNAD I V+ GQ++E G H LI+ G Y++L+ Q
Sbjct: 556 TTIIVAHRLSTVRNADTISVLHRGQLVEQGPHAELIKYSNGAYYQLLQLQEVNARRNGTY 615
Query: 1820 ------FADVDDKPKKKEAERRMSRQTSQRKGSVNFKTQES----------QVDXXXXXX 1951
+DV + + + R+S ++ + NF ++ S
Sbjct: 616 ELDPNRLSDVAN--RLSDVANRLSDAANRLSDAGNFVSRHSIRKLSFERSMSRHSSLGGS 673
Query: 1952 XXXXXXXXXXXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSL 2131
+ K L ++L +PE GA++P F L
Sbjct: 674 RRNSQTYALTEDEIEGCDDTKSGKNVLRRLLHLHKPETAILLLGCIAASANGAILPVFGL 733
Query: 2132 FFSQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSK 2311
S IN F P +++KD FWA ++++L V + Q +LF +A +L RIR+
Sbjct: 734 LLSSAINAFYEPPH-KLRKDSVFWAEIYVILGVVSIFIIPVQHTLFNMAGGKLIERIRAL 792
Query: 2312 VYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAF 2491
+ V+ QD +FD P +S G I RL+ DA ++KS L I +I++ G+ IA
Sbjct: 793 SFSRVVYQDIGWFDDPLNSSGAIGARLSADAASVKSIAGDVLSLIVQSISTALVGIVIAM 852
Query: 2492 YYGWQMAFLVMAIFPFM---AVGQALMMKYHGGSATSDAKEM-ENAGKTAMEAIENIRTV 2659
W++AF+V+ P + + Q+ +M+ G +DAKEM E A A +AI NIRTV
Sbjct: 853 IANWKLAFIVLCFVPCVFAQSYAQSRLMRGFG----ADAKEMYEQASTIASDAISNIRTV 908
Query: 2660 QALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDK 2839
+ + K+ + + P + + I G+ YGF+ ++ F YA +F G F
Sbjct: 909 TSFCVGEKIIESYRNKCKGPVKKGVRQGAISGVGYGFSFALLFCFYAVSFYVG--ARFVH 966
Query: 2840 NVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSG 3019
N + V +V FA++ + ++S ++ K AA IF +++ + +ID + G
Sbjct: 967 NGTADVGEVFKVFFALTMMAVGVSQSSSLARDFSKVQDAAASIFKIIDRKSKIDASSDDG 1026
Query: 3020 TYPQ-LSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQ------TLALVGPSGCGKSTV 3178
P+ + G ++ V F+YP R V I L + + G+ T+ALVG SG GKSTV
Sbjct: 1027 MAPEKIEGNIEFQHVSFKYPARTDVQIFTNLCLRIPSGKVHVVLMTVALVGESGSGKSTV 1086
Query: 3179 ISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGE 3358
++LLER YDP GA+ +D DL+ + LR+ I LV QEP+LF+ +IR NI YG Q +
Sbjct: 1087 VALLERFYDPDSGAIFLDGMDLKTLKLTWLRQQIGLVGQEPVLFNGTIRANIAYGKQ-DQ 1145
Query: 3359 YTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLL 3538
+ E+I AN H+FI LP GY+T VGE+G QLSGGQKQRIAIARA++++PK+LLL
Sbjct: 1146 VSEEEIVAVAEAANAHRFISSLPHGYDTSVGERGVQLSGGQKQRIAIARAILKDPKVLLL 1205
Query: 3539 DEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNE 3718
DEATSALD+ESE+ VQ ALD RT ++VAHRLSTI A I V+KNG V E+G H
Sbjct: 1206 DEATSALDSESERIVQEALDRVMVGRTTVIVAHRLSTITGADKIAVIKNGVVAEEGRHGR 1265
Query: 3719 LI-AKRGAYFALTQKQSSN 3772
L+ GAY +L QSS+
Sbjct: 1266 LLRLPGGAYASLVALQSSS 1284
>gi|27368855|emb|CAD59585.1| MDR-like ABC transporter [Oryza sativa
(japonica cultivar-group)]
Length = 1267
Score = 788 bits (2036), Expect = 0.0
Identities = 458/1247 (36%), Positives = 691/1247 (54%), Gaps = 16/1247 (1%)
Frame = +2
Query: 56 LYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAA 235
++RY VD+ ++AVG + + A G+ PLM+++ V F D ST
Sbjct: 35 MFRYADGVDKALMAVGTVAAMANGMSEPLMTVVFSAVIDCFGG------DDVSTVL---- 84
Query: 236 ARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAW 415
H V + L Y+YLG G A FLQ SC+ + E+ S R R + +++ Q+IA+
Sbjct: 85 ------HRVSKVVLYYIYLGVGTSMASFLQVSCWTMAGERQSARIRSLYLEAILTQDIAF 138
Query: 416 YD-KNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSL 592
+D + T+G ++++ + +++ G+KVG Q++ F+GGF + F W+L L++M+
Sbjct: 139 FDVEMTTGEAASRISADTVLIQDALGEKVGKYIQVLTAFVGGFVIGFIRGWMLALVVMAC 198
Query: 593 SPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDAL 772
P + Y+ AG + E+ + SIR V++FNG++ Y +
Sbjct: 199 IPPSIFSFALVSRLRAQISGKTHVSYSYAGNVVEQTIGSIRMVVSFNGEKRAITMYNTLI 258
Query: 773 EHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMG 952
+ K I + + G G+ S F ++Y SY LAFW G V S G V+ V F+++ G
Sbjct: 259 KKAYKATIMEGIISGFGIGSIFFVVYCSYSLAFWYGAKLVISKGYTGGQVINVVFAILTG 318
Query: 953 SMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTY 1132
SMA+G A + I AA L+E+I+R P ID T G I G + + V F+Y
Sbjct: 319 SMAIGNASPSISAIAEGQSAAHRLFEIINRKPNIDITGTSGIILEDIKGNVELKDVCFSY 378
Query: 1133 PTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDF 1312
P R + IL G+ L G T+A+VG SG GKSTII L++RFY+P G++LID I I+
Sbjct: 379 PARPEQLILDGLCLQVPNGTTMAIVGQSGSGKSTIISLVERFYDPQDGEVLIDGINIKTL 438
Query: 1313 NIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEGLN 1492
+ ++R + +VSQEP LF TSI+ NI YG+ + +DE+I RA + ANAA+FI P +
Sbjct: 439 KLHWIRGKMSLVSQEPLLFMTSIKDNITYGKENATDEEIKRAAELANAANFIDKLPNAYD 498
Query: 1493 TLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRT 1672
T+VG G Q+SGGQKQRIAIARA+++NPK+LLLDEATSALD ESE +VQ AL GRT
Sbjct: 499 TMVGQHGAQLSGGQKQRIAIARAILKNPKVLLLDEATSALDVESERLVQEALNRVMIGRT 558
Query: 1673 TIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLI-EQKGLYHELV-----HAQVFADVD 1834
T+++AHRLST++NAD I V+ G++++ G+H+ LI + G Y +L+ H + DV
Sbjct: 559 TLIVAHRLSTIKNADCIAVVHQGKIVDQGSHDELIKDPDGAYSQLIQLQQTHTEEMHDV- 617
Query: 1835 DKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXX----- 1999
+ + R SR S + +N + + +
Sbjct: 618 -QYSEVSTSRLKSRSLSLEQSMINDSPRNRRKNSLAKHIGSSGSDGLHKHGLTDEPEDKE 676
Query: 2000 -XXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRD 2176
KA + ++ +PE + G + P FS+ S I F P
Sbjct: 677 CGDNKDINKAPIRRLFNLNKPEAPILLLAIITAFVHGLLFPIFSIMMSGGIRTFYYPPH- 735
Query: 2177 QMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDM 2356
Q++KD FWALM +++A + S+ + LFG+A +L R+R +++++ Q+ ++FD
Sbjct: 736 QLRKDSRFWALMCILMAIISLVSIQLEYFLFGMAGGKLIERVRCLSFQSIVHQEVSWFDD 795
Query: 2357 PKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFP 2536
P HS G + +L DA NI+ + L + I ++ G IAF W++ +M P
Sbjct: 796 PSHSSGSLGAKLYIDALNIRRLVGDNLAILVQCIVTLIAGFTIAFASDWKLTLTIMCPIP 855
Query: 2537 FMAVGQALMMKYHGGSATSDAKEM-ENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLD 2713
+ + + +K+ G + DAK M E+A + EAI +IRTV + + ++ +
Sbjct: 856 LVGLQNYVQLKFLKG-FSEDAKVMYEDASQVVTEAIGSIRTVASFCAEKRVIKTYNQKCQ 914
Query: 2714 APHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGL-FLIFDKNVLMEPENVLRVLFAIS 2890
A +I ++ GL + F+ + + TYA F G F+ K+ ++V RV FA+
Sbjct: 915 ASMKESIRSGMVGGLGFSFSYLMVYLTYALCFYVGAQFVHGGKSTF---KDVFRVYFALV 971
Query: 2891 FSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSG-TYPQLSGEVKLNKVFF 3067
F+ I ++ + KA +A I +++ + ID G +++G ++LN V F
Sbjct: 972 FTAFGISQTSAMASDSSKAHESAASILAIIDRKSNIDSSIDEGIILEKVNGTIELNHVNF 1031
Query: 3068 RYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLR 3247
+YP RP V +L + + G+T+ALVG SG GKSTVI+LLER YDP G +++D +L+
Sbjct: 1032 KYPSRPDVQVLCDFTLGIPSGKTVALVGESGSGKSTVIALLERFYDPHSGTISLDRVELK 1091
Query: 3248 QMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELP 3427
+ LR + LVSQEPILF+ +I NI YG + G+ T E+I +N H+FI LP
Sbjct: 1092 NLKLSWLRDQMGLVSQEPILFNDTIHANIAYG-RKGQVTEEEIIAVAKASNAHEFISSLP 1150
Query: 3428 DGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAA 3607
GY T VGE+GTQLSGGQKQRIAIARA++++PKILLLDEATSALD ESE+ VQ ALD
Sbjct: 1151 QGYNTTVGERGTQLSGGQKQRIAIARAILKDPKILLLDEATSALDAESERIVQDALDQVM 1210
Query: 3608 KDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFA 3748
RT IVVAHRLSTI A I V+K+G + E+G H+ L+ G +A
Sbjct: 1211 VSRTTIVVAHRLSTIKGADVIAVIKDGSIAEKGQHDSLMRINGGVYA 1257
Score = 369 bits (946), Expect = e-100
Identities = 201/489 (41%), Positives = 292/489 (59%), Gaps = 4/489 (0%)
Frame = +2
Query: 353 KLSNRFRRQFFHSVMRQEIAWYD--KNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQ 526
KL R R F S++ QE++W+D ++SG+L KL+ + +R GD + + Q +
Sbjct: 772 KLIERVRCLSFQSIVHQEVSWFDDPSHSSGSLGAKLYIDALNIRRLVGDNLAILVQCIVT 831
Query: 527 FIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLT 706
I GF +AF DW LTL +M P + + Y A + E +
Sbjct: 832 LIAGFTIAFASDWKLTLTIMCPIPLVGLQNYVQLKFLKGFSEDAKVMYEDASQVVTEAIG 891
Query: 707 SIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTN 886
SIRTV +F ++ K Y + K I+ + G G + ++++Y +Y L F+VG
Sbjct: 892 SIRTVASFCAEKRVIKTYNQKCQASMKESIRSGMVGGLGFSFSYLMVYLTYALCFYVGAQ 951
Query: 887 FVYSGRLESGTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYS 1066
FV+ G+ V V+F+++ + + Q + A +AAS+ +IDR ID+
Sbjct: 952 FVHGGKSTFKDVFRVYFALVFTAFGISQTSAMASDSSKAHESAASILAIIDRKSNIDSSI 1011
Query: 1067 TEGQTPSKISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQL 1246
EG K++G I +N V F YP+R DV++L +L G+TVALVG SG GKST+I L
Sbjct: 1012 DEGIILEKVNGTIELNHVNFKYPSRPDVQVLCDFTLGIPSGKTVALVGESGSGKSTVIAL 1071
Query: 1247 LQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGR-SDVSDE 1423
L+RFY+P +G I +D + +++ + +LR +G+VSQEP LFN +I NI YGR V++E
Sbjct: 1072 LERFYDPHSGTISLDRVELKNLKLSWLRDQMGLVSQEPILFNDTIHANIAYGRKGQVTEE 1131
Query: 1424 DIARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEAT 1603
+I K +NA +FI + P+G NT VG+RG Q+SGGQKQRIAIARA++++PKILLLDEAT
Sbjct: 1132 EIIAVAKASNAHEFISSLPQGYNTTVGERGTQLSGGQKQRIAIARAILKDPKILLLDEAT 1191
Query: 1604 SALDAESESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIE- 1780
SALDAESE IVQ AL+ RTTIV+AHRLST++ AD I V+K G + E G H++L+
Sbjct: 1192 SALDAESERIVQDALDQVMVSRTTIVVAHRLSTIKGADVIAVIKDGSIAEKGQHDSLMRI 1251
Query: 1781 QKGLYHELV 1807
G+Y LV
Sbjct: 1252 NGGVYASLV 1260
Score = 340 bits (873), Expect = 1e-91
Identities = 209/561 (37%), Positives = 308/561 (54%), Gaps = 2/561 (0%)
Frame = +2
Query: 2096 LIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGV 2275
+ G P ++ FS +I+ F D + L ++ L + Q S + +
Sbjct: 55 MANGMSEPLMTVVFSAVIDCFGGDDVSTVLHRVSKVVLYYIYLGVGTSMASFLQVSCWTM 114
Query: 2276 AAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNA 2455
A ER + RIRS +L QD +FD+ + + G +R++ D I+ A+ ++G
Sbjct: 115 AGERQSARIRSLYLEAILTQDIAFFDV-EMTTGEAASRISADTVLIQDALGEKVGKYIQV 173
Query: 2456 IASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAME 2635
+ + GG I F GW +A +VMA P AL+ + + AG +
Sbjct: 174 LTAFVGGFVIGFIRGWMLALVVMACIPPSIFSFALVSRLRAQISGKTHVSYSYAGNVVEQ 233
Query: 2636 AIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRF 2815
I +IR V + + + ++ + + + I + II G G + + +Y+ AF +
Sbjct: 234 TIGSIRMVVSFNGEKRAITMYNTLIKKAYKATIMEGIISGFGIGSIFFVVYCSYSLAFWY 293
Query: 2816 GLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPR 2995
G L+ K V+ V+FAI IG A+ + AA +F ++ +P
Sbjct: 294 GAKLVISKGYT--GGQVINVVFAILTGSMAIGNASPSISAIAEGQSAAHRLFEIINRKPN 351
Query: 2996 IDGMTSSGTYPQ-LSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKS 3172
ID +SG + + G V+L V F YP RP IL GL + V G T+A+VG SG GKS
Sbjct: 352 IDITGTSGIILEDIKGNVELKDVCFSYPARPEQLILDGLCLQVPNGTTMAIVGQSGSGKS 411
Query: 3173 TVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQP 3352
T+ISL+ER YDP +G V +D +++ + +R ++LVSQEP+LF TSI++NI YG +
Sbjct: 412 TIISLVERFYDPQDGEVLIDGINIKTLKLHWIRGKMSLVSQEPLLFMTSIKDNITYGKEN 471
Query: 3353 GEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKIL 3532
T E+I+ A AN FID+LP+ Y+T VG+ G QLSGGQKQRIAIARA+++NPK+L
Sbjct: 472 A--TDEEIKRAAELANAANFIDKLPNAYDTMVGQHGAQLSGGQKQRIAIARAILKNPKVL 529
Query: 3533 LLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTH 3712
LLDEATSALD ESE+ VQ AL+ RT ++VAHRLSTI NA CI VV G++V+QG+H
Sbjct: 530 LLDEATSALDVESERLVQEALNRVMIGRTTLIVAHRLSTIKNADCIAVVHQGKIVDQGSH 589
Query: 3713 NELIA-KRGAYFALTQKQSSN 3772
+ELI GAY L Q Q ++
Sbjct: 590 DELIKDPDGAYSQLIQLQQTH 610
>gi|18033873|gb|AAL57243.1| ATP-binding cassette transporter ABC4
[Venturia inaequalis]
Length = 1353
Score = 786 bits (2030), Expect = 0.0
Identities = 471/1267 (37%), Positives = 696/1267 (54%), Gaps = 20/1267 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+ F LYRY S D + + S +G +PLM+++ G ++ +F D
Sbjct: 101 VGYFTLYRYASRWDWAAWWLSVFCSIVSGAAMPLMTVVFGGLTG-------LFADYFKNV 153
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
+E SH V L ++YL G F ++ F+ + E+ + + R ++ +++R
Sbjct: 154 ITYKQFNSELSHFV----LYFLYLAIGTFVTTYIMTVGFIYVGERCTGKIRERYLKAMLR 209
Query: 401 QEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLI 580
Q IA++DK +G ++ ++ + +++G +K GL +A FI F +AF W LTLI
Sbjct: 210 QNIAFFDKLGAGEVTTRITADTNLIQDGISEKFGLTLNALATFISAFVIAFIKYWKLTLI 269
Query: 581 MMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRY 760
+ S + + +YA G IAEEVL+S+R IAFN Q+ K Y
Sbjct: 270 LTSTVFAITLVMGVGSSFVVRWTVRSQTEYAKGGTIAEEVLSSVRNAIAFNTQDKLAKVY 329
Query: 761 EDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFS 940
+ L + G K +GA +AS +IY +Y L+FW G+ F+ G + VLTV F+
Sbjct: 330 DSYLVIAETNGRKLQMSLGAMIASMMTLIYLNYGLSFWQGSRFLVQGDMTVSQVLTVLFA 389
Query: 941 VMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKV 1120
VM+G+ +LG F +A+ A ++ IDR +D S +G+ K+SG I + V
Sbjct: 390 VMIGAFSLGNVAPNFKAFTSAVAAGQKIFAAIDRTSPMDPDSPDGKVLEKMSGPIELRNV 449
Query: 1121 EFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIP 1300
+ YP+R +V ++ GV L G+ ALVG+ G GKS I+ L++RFY P G++ +D
Sbjct: 450 KHIYPSRPEVVVMNGVDLIIPAGKQTALVGAFGSGKSPIVGLVERFYEPVGGEMFLDGHD 509
Query: 1301 IEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDED---------IARALKEAN 1453
I + N+ +LRQ + +V QEP LF T+I +NIR+G E I A K AN
Sbjct: 510 IREINLHWLRQNISLVQQEPVLFATTIYENIRFGLLGTEFEKVDPERQRDLIEGAAKMAN 569
Query: 1454 AADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESI 1633
A DFI EG T VG+RG +SGGQKQRIAIARA+V +PKILLLDEATSALD +SE +
Sbjct: 570 AHDFIMVLSEGYQTHVGERGFLLSGGQKQRIAIARAVVSDPKILLLDEATSALDTKSEGV 629
Query: 1634 VQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHA 1813
VQ+AL+ A++GRTTIVIAHRLST++NAD I+VM G ++E G H L+E+K Y LV A
Sbjct: 630 VQAALDKAAQGRTTIVIAHRLSTIKNADNIVVMSRGAIVEQGRHSELLERKSAYFNLVEA 689
Query: 1814 Q-VFADV-DDKPKKKEA-----ERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXX 1972
Q + A++ +D P++ E +++ R + KG E V
Sbjct: 690 QRIAAEIKNDNPEEVEILQEVDGQKLHRAATNEKGEPIDPDDEDPVGRLKRMQSGKSISS 749
Query: 1973 XXXXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIIN 2152
++ L + + + EW +I G P ++FF++ ++
Sbjct: 750 VELGKRGTEQTPEYSLLQLLGVVWSFNKTEWPIMLLGFICSVIAGGGNPVQAIFFAKAVS 809
Query: 2153 VFSNPDRD--QMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNV 2326
S P +++ + +FW+LM+L+LA Q S Q + FG +ERL R R + +R++
Sbjct: 810 ALSLPPAQYAELRSEINFWSLMYLMLAGTQLISNFGQATAFGYCSERLIHRARDQAFRHM 869
Query: 2327 LRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQ 2506
LRQD +FD +++ G +T+ L+T + + LG+I ++ + I+ GW+
Sbjct: 870 LRQDIEFFDREENNAGSLTSFLSTSSTQLSGLSGSTLGTILQVSTTLVVAMTISLAIGWK 929
Query: 2507 MAFLVMAIFP-FMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTK 2683
+A + ++ P +A G A + A + +AG A EA IRTV +LT +
Sbjct: 930 LALVCISAIPVLLACGFFRFWMLARFQARTKAAYVNSAG-FACEATSAIRTVASLTREED 988
Query: 2684 LYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPEN 2863
++ + + L+A ++ + Y + S FF A F +G LI +
Sbjct: 989 VFEKYHAQLEAQAKSSLVSILKSSALYAASQSFIFFCIALGFWYGGTLIAKREYSQFQFF 1048
Query: 2864 VLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGT-YPQLSG 3040
V +I F + G S+ P+ KA AA + + + +P+ID + G + G
Sbjct: 1049 VC--FMSIIFGAQSAGTIFSFAPDMGKAKHAAAELQTLFDRKPKIDCWSEEGDRLTSVEG 1106
Query: 3041 EVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGA 3220
V+ V FRYP RP P+L+GLN+ +KPGQ +ALVG SGCGKST I+LLER YDPL G
Sbjct: 1107 HVEFRDVHFRYPTRPEQPVLRGLNLSIKPGQYVALVGASGCGKSTTIALLERFYDPLSGG 1166
Query: 3221 VTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKAN 3400
V VD ++ ++N R ++ALVSQEP L+ +IREN++ G ++I AC AN
Sbjct: 1167 VYVDGQEVSKLNVNDYRSYLALVSQEPTLYQGTIRENVLLGADREGVPEDEIIRACKDAN 1226
Query: 3401 IHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQ 3580
I+ FI LPDG+ T G+KG LSGGQKQRIAIARAL+RNPKILLLDEATSALD+ESE+
Sbjct: 1227 IYDFIMSLPDGFNTVCGQKGGLLSGGQKQRIAIARALLRNPKILLLDEATSALDSESEQI 1286
Query: 3581 VQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQK 3760
VQ+ALD AAK RT I VAHRLSTI A I V+ G+VVE+G+HN L++K G Y L
Sbjct: 1287 VQLALDKAAKGRTTIAVAHRLSTIQKADVIYVIDGGRVVEEGSHNYLLSKNGRYAELVMM 1346
Query: 3761 QSSNQSG 3781
QS ++G
Sbjct: 1347 QSLEKAG 1353
>gi|50260330|gb|EAL22989.1| hypothetical protein CNBA7570
[Cryptococcus neoformans var. neoformans B-3501A]
Length = 1408
Score = 785 bits (2026), Expect = 0.0
Identities = 477/1285 (37%), Positives = 705/1285 (54%), Gaps = 43/1285 (3%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIF------- 199
+S F L+R+ + ++ + + +G++++ A G PLM++I G ++ +F I
Sbjct: 139 VSFFALFRFAAPLEIVAMVLGLVLAVAAGCCQPLMTLIFGRLTTSFTNYAVIVNQISQVG 198
Query: 200 LDPNSTASEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQ 379
L P ++A+ +AA + + + N L + +G +F A +L + V E S R R +
Sbjct: 199 LTPETSAALQAA-KDDLKTQSGHNALYLMAIGIAMFLATWLYMFIWNVTGELNSKRIRER 257
Query: 380 FFHSVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTY 559
+ +V+RQEIA++D +G ++ ++ + V+EGT +KV L FQ F+ GF +AF
Sbjct: 258 YLAAVLRQEIAYFDDLGAGEVATRIQTDCHLVQEGTSEKVALVFQYAGTFVCGFVLAFVR 317
Query: 560 DWLLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQ 739
L ++S+ P +M+CG A AG +AEEV+ SIRTV AF +
Sbjct: 318 SPRLAGALISILPVIMLCGGIMMTAMAKFGTAALDHIAKAGSLAEEVIASIRTVQAFGKE 377
Query: 740 EYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGT 919
+ ++ D +E K G K S G GL+ F IYA+Y LAF+ G V GR +SG
Sbjct: 378 KILGDKFADHIEQSKIVGRKGSIFEGFGLSIMFFAIYAAYALAFFYGGVLVSQGRADSGI 437
Query: 920 VLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISG 1099
V+ VF S+++GS ++ + A + A GAAA L+ IDR+P ID+ S EG P + G
Sbjct: 438 VINVFMSILIGSFSMAMLAPELAAVTKARGAAAKLFATIDRVPTIDSASDEGLKPDSLHG 497
Query: 1100 RISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQ 1279
IS V+F YP+R V ILKG + + G+T ALVG+SG GKST++ L++RFY+P +G
Sbjct: 498 EISFENVKFHYPSRPSVPILKGFTTTFEAGKTFALVGASGSGKSTVVSLIERFYDPISGV 557
Query: 1280 ILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYG-----RSDVSDED----IA 1432
+ +D I N+ +LRQ +G+VSQEP LF T++ N+ +G + S E+ +
Sbjct: 558 VKLDGKDIRSLNLNWLRQQIGLVSQEPTLFGTTVRGNVEHGLIGSRYENASFEEKFELVK 617
Query: 1433 RALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSAL 1612
+A +ANA DFI P+G +T+VG+RG+ +SGGQKQR+AIARA+V +P+ILLLDEATSAL
Sbjct: 618 KACVDANAHDFIMKLPQGYDTMVGERGMLLSGGQKQRVAIARAIVSDPRILLLDEATSAL 677
Query: 1613 DAESESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLI-EQKG 1789
D +SE IVQ AL+ ASRGRTTI IAHRLST+R+AD+I VM G+V+E G+H L+ + G
Sbjct: 678 DTQSEGIVQDALDKASRGRTTITIAHRLSTIRDADRIYVMGGGEVLEQGSHNDLLANENG 737
Query: 1790 LYHELVHAQVFA------------DVDD---------KPKKKEAERRMSRQTSQRKGSVN 1906
Y +LV+ Q A D+DD +E +R++ R + R +
Sbjct: 738 PYAQLVNNQKLAQEAAAEALQVDDDIDDPDDVVFGGPSSPMQEKDRQLHRAVTGR-SLAS 796
Query: 1907 FKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXX 2086
+ Q ++LR +
Sbjct: 797 IAMDDIQAKRAEEVAGEDKIPSSFGLYA---------------RLLRMNSADKFIYIIAF 841
Query: 2087 XXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSL 2266
+ G V PA ++ F + ++ F D +++ AL + + A G + FQ +
Sbjct: 842 IAAICAGMVYPALAILFGKALSDFEIQDPTELRDALSRRALWYFITALAAGFVIFFQSAG 901
Query: 2267 FGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSI 2446
F A L +R K++ + LR D +FD +S G +T+ LA ++ LG+I
Sbjct: 902 FSHAGWDLNGVLRKKLFTSTLRHDIEWFDEEHNSTGAVTSNLADQPQKVQGLFGPTLGTI 961
Query: 2447 FNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKT 2626
+ A++ GG I YG +A + +A P + G + +K K +
Sbjct: 962 IQSCATLLGGCIIGLCYGPLLALIGIACIPILVSGGYIRLKVVVLKDQRMKKLHAASAHL 1021
Query: 2627 AMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAA 2806
A EA ++TV +LT + + I+ L AP N +I + + + F A
Sbjct: 1022 ASEAAGAVKTVASLTREKDVREIYSEALKAPMKLNFRTSIKSQCLFAASQGLTFCIIALV 1081
Query: 2807 FRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEE 2986
F G I N + VL +I F+ G ++ P+ KA +A IF ++
Sbjct: 1082 FYIGALWII--NGKYTTASFYTVLNSIVFASIQAGNVFTFVPDASKANSSAASIFRSIDN 1139
Query: 2987 EPRIDGMTSSG---TYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPS 3157
EP I+ +S G + + G V++ V FRYP RP V +L+ L + V G +ALVGPS
Sbjct: 1140 EPAINAESSEGKVLDHEHVVGHVRIEGVHFRYPTRPGVRVLRNLTIDVPAGTYVALVGPS 1199
Query: 3158 GCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIV 3337
GCGKST I +LER YDPL G VT+D D++++N R I+LVSQEP L+ +IR NI+
Sbjct: 1200 GCGKSTTIQMLERFYDPLAGRVTLDGIDIKELNLASYRSQISLVSQEPTLYAGTIRFNIL 1259
Query: 3338 YGLQP--GEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARAL 3511
G E T ++I++AC ANI+ FI LPDG++T VG KG+QLSGGQKQRIAIARAL
Sbjct: 1260 LGANKPLEEVTQDEIDSACKDANIYDFIVSLPDGFDTEVGGKGSQLSGGQKQRIAIARAL 1319
Query: 3512 IRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQ 3691
IRNPK+LLLDEATSALD++SEK VQ ALD AAK RT I +AHRLS+I ++ I G+
Sbjct: 1320 IRNPKVLLLDEATSALDSQSEKVVQEALDKAAKGRTTIAIAHRLSSIQHSDQIYYFSEGR 1379
Query: 3692 VVEQGTHNELIAKRGAYFALTQKQS 3766
V EQGTH EL++K+G Y+ L Q Q+
Sbjct: 1380 VAEQGTHQELLSKKGGYYELVQMQN 1404
Score = 336 bits (862), Expect = 2e-90
Identities = 223/625 (35%), Positives = 319/625 (50%), Gaps = 38/625 (6%)
Frame = +2
Query: 2027 NLFKILRYARP-EWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSN------------- 2164
+ F + R+A P E + + G P +L F ++ F+N
Sbjct: 140 SFFALFRFAAPLEIVAMVLGLVLAVAAGCCQPLMTLIFGRLTTSFTNYAVIVNQISQVGL 199
Query: 2165 -PD--------RDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVY 2317
P+ +D +K AL + + + ++ V E + RIR +
Sbjct: 200 TPETSAALQAAKDDLKTQSGHNALYLMAIGIAMFLATWLYMFIWNVTGELNSKRIRERYL 259
Query: 2318 RNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYY 2497
VLRQ+ YFD G + TR+ TD ++ ++ +F + G +AF
Sbjct: 260 AAVLRQEIAYFD--DLGAGEVATRIQTDCHLVQEGTSEKVALVFQYAGTFVCGFVLAFVR 317
Query: 2498 GWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQ 2677
++A +++I P + + +MM T+ + AG A E I +IRTVQA +
Sbjct: 318 SPRLAGALISILPVIMLCGGIMMTAMAKFGTAALDHIAKAGSLAEEVIASIRTVQAFGKE 377
Query: 2678 TKLYNIFCSHLDAPHGGNISKAIIR--GLTYGFANSIQFFT----YAAAFRFGLFLIFDK 2839
L + F H++ SK + R + GF SI FF YA AF +G L+
Sbjct: 378 KILGDKFADHIEQ------SKIVGRKGSIFEGFGLSIMFFAIYAAYALAFFYGGVLVSQG 431
Query: 2840 NVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSG 3019
+ V+ V +I ++ A KA AA +F ++ P ID + G
Sbjct: 432 RA--DSGIVINVFMSILIGSFSMAMLAPELAAVTKARGAAAKLFATIDRVPTIDSASDEG 489
Query: 3020 TYPQ-LSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLER 3196
P L GE+ V F YP RP+VPIL+G + G+T ALVG SG GKSTV+SL+ER
Sbjct: 490 LKPDSLHGEISFENVKFHYPSRPSVPILKGFTTTFEAGKTFALVGASGSGKSTVVSLIER 549
Query: 3197 LYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTH--- 3367
YDP+ G V +D D+R +N LR+ I LVSQEP LF T++R N+ +GL Y +
Sbjct: 550 FYDPISGVVKLDGKDIRSLNLNWLRQQIGLVSQEPTLFGTTVRGNVEHGLIGSRYENASF 609
Query: 3368 ----EQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILL 3535
E ++ AC AN H FI +LP GY+T VGE+G LSGGQKQR+AIARA++ +P+ILL
Sbjct: 610 EEKFELVKKACVDANAHDFIMKLPQGYDTMVGERGMLLSGGQKQRVAIARAIVSDPRILL 669
Query: 3536 LDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHN 3715
LDEATSALDT+SE VQ ALD A++ RT I +AHRLSTI +A I V+ G+V+EQG+HN
Sbjct: 670 LDEATSALDTQSEGIVQDALDKASRGRTTITIAHRLSTIRDADRIYVMGGGEVLEQGSHN 729
Query: 3716 ELIA-KRGAYFALTQKQSSNQSGGA 3787
+L+A + G Y L Q Q A
Sbjct: 730 DLLANENGPYAQLVNNQKLAQEAAA 754
>gi|49080124|ref|XP_403624.1| hypothetical protein UM06009.1 [Ustilago
maydis 521]
gi|46101640|gb|EAK86873.1| hypothetical protein UM06009.1 [Ustilago
maydis 521]
Length = 1470
Score = 782 bits (2020), Expect = 0.0
Identities = 467/1294 (36%), Positives = 694/1294 (53%), Gaps = 57/1294 (4%)
Frame = +2
Query: 53 QLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKA 232
+LYRY + D + +G+I + A G PLM+I+ G+++ F+ L +
Sbjct: 180 ELYRYATVWDHIFNLIGLIAAAAAGAVQPLMTIVFGSLTTAFLEYSNALLFNGDILT--- 236
Query: 233 AARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIA 412
AR HE++ L VY+G + A ++ + ++ E ++ R R ++ +++RQ+IA
Sbjct: 237 -ARDHLDHEIVHGVLFLVYIGIAMLVATYVYMAAWVYTGEVITRRTREKYLEAILRQDIA 295
Query: 413 WYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSL 592
++D +G ++ ++ +++ ++EG DK+ ++ ++ F+ GF VA+ W L L + S+
Sbjct: 296 YFDLVGAGEITTRIQTDIQLIQEGISDKIPMSVMFISAFVTGFIVAYVKSWQLALALSSM 355
Query: 593 SPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDAL 772
P ++I G + + A IAEE L ++RT AF + + Y+ +
Sbjct: 356 IPCIIIAGALMNAVTAKLQQAELDRVSKAASIAEEALATLRTAKAFGIEHDLVQLYDQSN 415
Query: 773 EHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMG 952
+ GIK+S G G+ FF +IY+ Y LAF+ G + SG + SGTV+ V FS+++G
Sbjct: 416 RQATRFGIKRSLYQGIGMGVFFFVIYSGYALAFYFGAKLLASGHIASGTVMNVIFSILIG 475
Query: 953 SMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTY 1132
+ ++ + A A A ++E IDR+P ID+ G P G + ++++F+Y
Sbjct: 476 AFSMAMMAPNMQALSYAFAAGAKVFETIDRVPPIDSSDPSGLRPEACQGHLEFHQIDFSY 535
Query: 1133 PTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDF 1312
PTR DV +L+ SL G+ ALVG+SG GKSTI+ L++RFY+PDAG +L+D + + D
Sbjct: 536 PTRPDVPVLEAFSLQVPAGKVTALVGASGSGKSTIVSLVERFYDPDAGAVLLDCVDVRDL 595
Query: 1313 NIKYLRQLVGVVSQEPNLFNTSIEQNIRYGR-----SDVSDED----IARALKEANAADF 1465
N+K+LR +G+VSQEP LF+T+I NI +G S+++ I A ANA F
Sbjct: 596 NLKWLRTQIGLVSQEPTLFSTTIRANIAHGLINTPFQHASEQEQQKLIIDAANMANAHGF 655
Query: 1466 IKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSA 1645
I P G +T+VG+RG +SGGQKQRIAIARA+V+NP ILLLDEATSALD +SE++VQ A
Sbjct: 656 ISQLPNGYDTMVGERGFLLSGGQKQRIAIARAIVKNPSILLLDEATSALDTQSEAVVQDA 715
Query: 1646 LENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQ--- 1816
LE AS+ RTTI IAHRLST++NADKI+VM G ++E G H L+E G Y +LV AQ
Sbjct: 716 LEQASQNRTTITIAHRLSTIKNADKIVVMGKGVILETGQHNELLELNGAYAQLVDAQNIR 775
Query: 1817 -----------VFADVDDKPKKKEAE---------RRMSRQTSQRKGSVNFKTQ------ 1918
V D DD ++ A+ + T K +V + +
Sbjct: 776 AKVGNKIVEEGVIDDDDDDDDQQAAQPAKFVASNAKVPLAVTDDAKAAVRQEAKAEMPAG 835
Query: 1919 -ESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXGAVKANLFKILRYARPE-WIYXXXXXXX 2092
E V ++ L+++ + R +
Sbjct: 836 LEKSVTHQSVASAILHQRQREQATRDEEPEKIPSIFYLLYRLAKINRDHVFTLYVPGVIA 895
Query: 2093 XLIQGAVMPAFSLFFSQIINVFS-----------NPDRDQMKKDGHFWALMFLVLAAVQG 2239
+ GA P FSL F + FS P R M D + WAL F V+A +
Sbjct: 896 SICSGAAYPCFSLLFGHALQNFSLCSAIGGGACPEPARSTMLHDANLWALYFFVIAILCT 955
Query: 2240 TSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKS 2419
++ Q A+ L R+R LR D +Y D HS G ++ LA ++ I
Sbjct: 956 LAISIQTYTLMKASCVLMERMRRMSLFAYLRADVSYHDQDAHSSGALSNSLADNSQKING 1015
Query: 2420 AIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDA 2599
+ LG+I +I+++ G IA GW+++ +V+A P A ++ H DA
Sbjct: 1016 LVGVTLGTIIQSISTLVTGAIIALANGWKLSLVVIACIPLTL--SAGFVRLH-LVVLKDA 1072
Query: 2600 K---EMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGF 2770
+ E + A EA +R V +LT + I+ LDAP + + A Y
Sbjct: 1073 RLKTAYEGSAAKACEAAGAMRVVASLTREQDCLEIYRRELDAPSRISRNTAFYGNFLYAV 1132
Query: 2771 ANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKAT 2950
+ ++QF+ F +G L+ +L A+ F A S+ P+ A
Sbjct: 1133 SQALQFWIIGLGFWYGSKLLISGE--YTSGQYFTILTAVVFGSIQASNAFSFVPDISNAK 1190
Query: 2951 FAAGLIFNMLEEEPRIDGMTSSG-TYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKP 3127
AA +L+ P ID + G ++ G V+L+KV FRYP RP V +L+G+++ VKP
Sbjct: 1191 TAAWDSIKLLDMVPEIDVTSDQGEVLDKVEGHVRLDKVHFRYPTRPTVKVLRGVDIEVKP 1250
Query: 3128 GQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPIL 3307
G +ALVG SGCGKST + L++R YDPL G V +D D+R +N +RKH+ALVSQEP L
Sbjct: 1251 GTFVALVGASGCGKSTTVQLMQRFYDPLSGRVLIDGKDIRTLNLAEIRKHMALVSQEPTL 1310
Query: 3308 FDTSIRENIVYGL--QPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQ 3481
+D SI NI G + + + A + ANI FI+ LPD ++T+VG KGTQLSGGQ
Sbjct: 1311 YDGSIEFNIRLGAFQDASSVSMDDLRAAAASANILAFIESLPDKWDTQVGAKGTQLSGGQ 1370
Query: 3482 KQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNA 3661
KQRIAIARALIRNP+ILLLDEATSALD++SEK VQ ALD AA RT I +AHRLSTI A
Sbjct: 1371 KQRIAIARALIRNPRILLLDEATSALDSDSEKLVQEALDKAAAGRTTIAIAHRLSTISRA 1430
Query: 3662 GCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQ 3763
I V+K+G+V E G+H +L+ + G Y L + Q
Sbjct: 1431 DLIYVLKDGKVHEHGSHIDLLNRNGVYADLVRMQ 1464
Score = 356 bits (914), Expect = 2e-96
Identities = 222/606 (36%), Positives = 328/606 (53%), Gaps = 15/606 (2%)
Frame = +2
Query: 44 SIFQLYRYTSTVDR----LMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPN 211
SIF L + ++R + G+I S +G P S++ G+ QNF I
Sbjct: 869 SIFYLLYRLAKINRDHVFTLYVPGVIASICSGAAYPCFSLLFGHALQNFSLCSAI----- 923
Query: 212 STASEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHS 391
+ AR+ H+ L + + A +Q M L R RR +
Sbjct: 924 GGGACPEPARSTMLHDANLWALYFFVIAILCTLAISIQTYTLMKASCVLMERMRRMSLFA 983
Query: 392 VMRQEIAWYDKN--TSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDW 565
+R +++++D++ +SG LSN L DN +++ G +G Q ++ + G +A W
Sbjct: 984 YLRADVSYHDQDAHSSGALSNSLADNSQKINGLVGVTLGTIIQSISTLVTGAIIALANGW 1043
Query: 566 LLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEY 745
L+L++++ P + G Y + A E ++R V + +E
Sbjct: 1044 KLSLVVIACIPLTLSAGFVRLHLVVLKDARLKTAYEGSAAKACEAAGAMRVVASLT-REQ 1102
Query: 746 EC----KRYEDALEH-GKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLE 910
+C +R DA + T +FL A F II L FW G+ + SG
Sbjct: 1103 DCLEIYRRELDAPSRISRNTAFYGNFLYAVSQALQFWIIG----LGFWYGSKLLISGEYT 1158
Query: 911 SGTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSK 1090
SG T+ +V+ GS+ A I A AA +++D +PEID S +G+ K
Sbjct: 1159 SGQYFTILTAVVFGSIQASNAFSFVPDISNAKTAAWDSIKLLDMVPEIDVTSDQGEVLDK 1218
Query: 1091 ISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPD 1270
+ G + ++KV F YPTR VK+L+GV ++ +PG VALVG+SGCGKST +QL+QRFY+P
Sbjct: 1219 VEGHVRLDKVHFRYPTRPTVKVLRGVDIEVKPGTFVALVGASGCGKSTTVQLMQRFYDPL 1278
Query: 1271 AGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYG----RSDVSDEDIARA 1438
+G++LID I N+ +R+ + +VSQEP L++ SIE NIR G S VS +D+ A
Sbjct: 1279 SGRVLIDGKDIRTLNLAEIRKHMALVSQEPTLYDGSIEFNIRLGAFQDASSVSMDDLRAA 1338
Query: 1439 LKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDA 1618
AN FI++ P+ +T VG +G Q+SGGQKQRIAIARAL+RNP+ILLLDEATSALD+
Sbjct: 1339 AASANILAFIESLPDKWDTQVGAKGTQLSGGQKQRIAIARALIRNPRILLLDEATSALDS 1398
Query: 1619 ESESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYH 1798
+SE +VQ AL+ A+ GRTTI IAHRLST+ AD I V+K G+V E G+H L+ + G+Y
Sbjct: 1399 DSEKLVQEALDKAAAGRTTIAIAHRLSTISRADLIYVLKDGKVHEHGSHIDLLNRNGVYA 1458
Query: 1799 ELVHAQ 1816
+LV Q
Sbjct: 1459 DLVRMQ 1464
Score = 332 bits (850), Expect = 6e-89
Identities = 213/598 (35%), Positives = 313/598 (51%), Gaps = 21/598 (3%)
Frame = +2
Query: 2036 KILRYARP-EWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFS--------NPD----RD 2176
++ RYA + I+ GAV P ++ F + F N D RD
Sbjct: 180 ELYRYATVWDHIFNLIGLIAAAAAGAVQPLMTIVFGSLTTAFLEYSNALLFNGDILTARD 239
Query: 2177 QMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDM 2356
+ + L + + + + + E +T R R K +LRQD YFD+
Sbjct: 240 HLDHEIVHGVLFLVYIGIAMLVATYVYMAAWVYTGEVITRRTREKYLEAILRQDIAYFDL 299
Query: 2357 PKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFP 2536
G ITTR+ TD I+ I ++ I++ G +A+ WQ+A + ++ P
Sbjct: 300 V--GAGEITTRIQTDIQLIQEGISDKIPMSVMFISAFVTGFIVAYVKSWQLALALSSMIP 357
Query: 2537 FMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDA 2716
+ + ALM ++ + A A EA+ +RT +A ++ L ++
Sbjct: 358 CIIIAGALMNAVTAKLQQAELDRVSKAASIAEEALATLRTAKAFGIEHDLVQLYDQSNRQ 417
Query: 2717 PHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFS 2896
I +++ +G+ G + + YA AF FG L+ ++ V+ V+F+I
Sbjct: 418 ATRFGIKRSLYQGIGMGVFFFVIYSGYALAFYFGAKLLASGHIASG--TVMNVIFSILIG 475
Query: 2897 FGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQL-SGEVKLNKVFFRY 3073
++ A A A +F ++ P ID SG P+ G ++ +++ F Y
Sbjct: 476 AFSMAMMAPNMQALSYAFAAGAKVFETIDRVPPIDSSDPSGLRPEACQGHLEFHQIDFSY 535
Query: 3074 PERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQM 3253
P RP VP+L+ ++ V G+ ALVG SG GKST++SL+ER YDP GAV +D D+R +
Sbjct: 536 PTRPDVPVLEAFSLQVPAGKVTALVGASGSGKSTIVSLVERFYDPDAGAVLLDCVDVRDL 595
Query: 3254 NPKHLRKHIALVSQEPILFDTSIRENIVYGL--QPGEYTHEQ-----IETACSKANIHKF 3412
N K LR I LVSQEP LF T+IR NI +GL P ++ EQ I A + AN H F
Sbjct: 596 NLKWLRTQIGLVSQEPTLFSTTIRANIAHGLINTPFQHASEQEQQKLIIDAANMANAHGF 655
Query: 3413 IDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVA 3592
I +LP+GY+T VGE+G LSGGQKQRIAIARA+++NP ILLLDEATSALDT+SE VQ A
Sbjct: 656 ISQLPNGYDTMVGERGFLLSGGQKQRIAIARAIVKNPSILLLDEATSALDTQSEAVVQDA 715
Query: 3593 LDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQS 3766
L+ A+++RT I +AHRLSTI NA I+V+ G ++E G HNEL+ GAY L Q+
Sbjct: 716 LEQASQNRTTITIAHRLSTIKNADKIVVMGKGVILETGQHNELLELNGAYAQLVDAQN 773
>gi|11346278|pir||T43261 multidrug resistance protein 1 - fungus
(Filobasidium floriforme)
gi|2668553|gb|AAC49889.1| multidrug resistance protein 1
[Filobasidiella neoformans]
gi|2668555|gb|AAC49890.1| multidrug resistance protein 1
[Filobasidiella neoformans]
Length = 1408
Score = 778 bits (2008), Expect = 0.0
Identities = 470/1276 (36%), Positives = 704/1276 (54%), Gaps = 34/1276 (2%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIF------- 199
+S F L+R+ + ++ + + +G++++ A G PLM++I G ++ +F I
Sbjct: 139 VSFFALFRFAAPLEIIAMVLGLVLAVAAGSCQPLMTLIFGRLTTSFTNYAVIANQISQGG 198
Query: 200 LDPNSTASEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQ 379
L P ++A+ +AA + + + N L + +G G+F A +L + V E S R R +
Sbjct: 199 LTPETSAALQAA-KDDLKTQSGHNALYLMAIGIGMFLATWLYMFIWNVTGELNSKRIRER 257
Query: 380 FFHSVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTY 559
+ +V+RQEIA++D +G ++ ++ + V+EGT +KV L FQ F+ GF +AF
Sbjct: 258 YLAAVLRQEIAYFDDLGAGEVATRIQTDCHLVQEGTSEKVALVFQYAGTFVCGFVLAFVR 317
Query: 560 DWLLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQ 739
L ++S+ P +M+CG A AG +AEEV+ SIRTV AF +
Sbjct: 318 SPRLAGALVSILPVIMLCGGIMMTAMAKYGTAALDHIAKAGSLAEEVIGSIRTVQAFGKE 377
Query: 740 EYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGT 919
+ ++ D +E K G K S G GL+ F +IYA+Y LAF+ G V +G+ +SG
Sbjct: 378 KILGDKFADHIEQSKIVGRKGSIFEGFGLSIMFFVIYAAYALAFFYGGILVSNGQADSGI 437
Query: 920 VLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISG 1099
V+ VF S+++GS ++ + A + A GAAA L+ IDR+P ID+ S EG P + G
Sbjct: 438 VINVFMSILIGSFSMAMLAPELAAVTKARGAAAKLFATIDRVPAIDSASEEGFKPDGLRG 497
Query: 1100 RISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQ 1279
IS V+F YP+R + ILKG + + G+T ALVG+SG GKST++ L++RFY+P +G
Sbjct: 498 EISFENVKFHYPSRPSIPILKGFTTTFEAGKTFALVGASGSGKSTVVSLIERFYDPVSGV 557
Query: 1280 ILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNI-------RYGRSDVSD--EDIA 1432
+ +D I N+ +LRQ +G+VSQEP LF T++ N+ RY + + + E +
Sbjct: 558 VKLDGRDIRSLNLNWLRQQIGLVSQEPTLFGTTVRGNVEHGLIGSRYENASLEEKFELVK 617
Query: 1433 RALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSAL 1612
+A +ANA +FI P+G +T+VG+RG+ +SGGQKQR+AIARA+V +P+ILLLDEATSAL
Sbjct: 618 KACVDANAHNFIMKLPQGYDTMVGERGMLLSGGQKQRVAIARAIVSDPRILLLDEATSAL 677
Query: 1613 DAESESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLI-EQKG 1789
D +SE IVQ AL+ ASRGRTTI IAHRLST+R+AD+I VM G+V+E G+H L+ + G
Sbjct: 678 DTQSEGIVQDALDKASRGRTTITIAHRLSTIRDADRIYVMGGGEVLEQGSHNDLLANENG 737
Query: 1790 LYHELVHAQVFA--------DVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXX 1945
Y +LV+ Q A VDD + + + GS + ++ Q+
Sbjct: 738 PYAQLVNNQKLAQEAAAEALQVDDDIEDPDDAVFIG-------GSSPMQEKDKQLHRAVT 790
Query: 1946 XXXXXXXXXXXXXXXXXXXXXXGAVKANLF----KILRYARPEWIYXXXXXXXXLIQGAV 2113
+ F ++LR + + G V
Sbjct: 791 GRSLASIAMDDIQAKRAEEVAGEDKIPSSFGLYARLLRMNSADKFIYIIAFIAAICAGMV 850
Query: 2114 MPAFSLFFSQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLT 2293
P+ ++ F + ++ F D +++ AL + + A + FQ + F A L
Sbjct: 851 YPSLAILFGKALSDFEIQDPAELRHALSRSALWYFITALAAAFVIFFQSAGFSRAGWDLN 910
Query: 2294 MRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGG 2473
+R K++ LR D +FD ++S G +T+ LA ++ LG++ + A++ G
Sbjct: 911 GVLRKKLFTATLRHDIEWFDEERNSTGAVTSNLADQPQKVQGLFGPTLGTVVQSCATLIG 970
Query: 2474 GLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIR 2653
G I YG +A + +A P + G + +K K + A EA ++
Sbjct: 971 GCIIGLCYGPLLALIGIACIPILVSGGYIRLKVVVLKDQRMKKLHAASAHLASEAAGAVK 1030
Query: 2654 TVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIF 2833
TV +LT + + I+ L AP N +I + + + F A F G I
Sbjct: 1031 TVASLTREKDVRRIYSEALKAPMKLNFRTSIKSQCLFAASQGLTFCIIALVFYIGALWII 1090
Query: 2834 DKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTS 3013
D + VL +I F+ G ++ P+ KA +A IF ++ EP I+ ++
Sbjct: 1091 DAK--YSTASFYTVLNSIVFASIQAGNVFTFVPDASKANSSAASIFRSIDNEPAINAESN 1148
Query: 3014 SG---TYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVIS 3184
G + + G V++ V FRYP RP V +L+ L + V G +ALVGPSGCGKST I
Sbjct: 1149 EGKVLDHKHVVGHVRIEGVHFRYPTRPGVRVLRNLTIDVPAGTYVALVGPSGCGKSTTIQ 1208
Query: 3185 LLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQP--GE 3358
+LER YDPL G VT+D D++++N R I+LVSQEP L+ +IR NI+ G E
Sbjct: 1209 MLERFYDPLAGRVTLDGIDIKELNLASYRSQISLVSQEPTLYAGTIRFNILLGANKPIEE 1268
Query: 3359 YTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLL 3538
T ++I+ AC ANI+ FI LPDG++T VG KG+QLSGGQKQRIAIARALIRNPK+LLL
Sbjct: 1269 VTQDEIDAACKDANIYDFIVSLPDGFDTEVGGKGSQLSGGQKQRIAIARALIRNPKVLLL 1328
Query: 3539 DEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNE 3718
DEATSALD++SEK VQ ALD AAK RT I +AHRLS+I ++ I G+V E GTH E
Sbjct: 1329 DEATSALDSQSEKVVQEALDKAAKGRTTIAIAHRLSSIQHSDRIYYFSEGRVAEHGTHQE 1388
Query: 3719 LIAKRGAYFALTQKQS 3766
L+AK+G Y+ L Q Q+
Sbjct: 1389 LLAKKGGYYELVQMQN 1404
Score = 337 bits (863), Expect = 2e-90
Identities = 224/625 (35%), Positives = 321/625 (50%), Gaps = 38/625 (6%)
Frame = +2
Query: 2027 NLFKILRYARP-EWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSN------------- 2164
+ F + R+A P E I + G+ P +L F ++ F+N
Sbjct: 140 SFFALFRFAAPLEIIAMVLGLVLAVAAGSCQPLMTLIFGRLTTSFTNYAVIANQISQGGL 199
Query: 2165 -PD--------RDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVY 2317
P+ +D +K AL + + + ++ V E + RIR +
Sbjct: 200 TPETSAALQAAKDDLKTQSGHNALYLMAIGIGMFLATWLYMFIWNVTGELNSKRIRERYL 259
Query: 2318 RNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYY 2497
VLRQ+ YFD G + TR+ TD ++ ++ +F + G +AF
Sbjct: 260 AAVLRQEIAYFD--DLGAGEVATRIQTDCHLVQEGTSEKVALVFQYAGTFVCGFVLAFVR 317
Query: 2498 GWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQ 2677
++A +++I P + + +MM T+ + AG A E I +IRTVQA +
Sbjct: 318 SPRLAGALVSILPVIMLCGGIMMTAMAKYGTAALDHIAKAGSLAEEVIGSIRTVQAFGKE 377
Query: 2678 TKLYNIFCSHLDAPHGGNISKAIIR--GLTYGFANSIQFFT----YAAAFRFGLFLIFDK 2839
L + F H++ SK + R + GF SI FF YA AF +G L+
Sbjct: 378 KILGDKFADHIEQ------SKIVGRKGSIFEGFGLSIMFFVIYAAYALAFFYGGILV--S 429
Query: 2840 NVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSG 3019
N + V+ V +I ++ A KA AA +F ++ P ID + G
Sbjct: 430 NGQADSGIVINVFMSILIGSFSMAMLAPELAAVTKARGAAAKLFATIDRVPAIDSASEEG 489
Query: 3020 TYPQ-LSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLER 3196
P L GE+ V F YP RP++PIL+G + G+T ALVG SG GKSTV+SL+ER
Sbjct: 490 FKPDGLRGEISFENVKFHYPSRPSIPILKGFTTTFEAGKTFALVGASGSGKSTVVSLIER 549
Query: 3197 LYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTH--- 3367
YDP+ G V +D D+R +N LR+ I LVSQEP LF T++R N+ +GL Y +
Sbjct: 550 FYDPVSGVVKLDGRDIRSLNLNWLRQQIGLVSQEPTLFGTTVRGNVEHGLIGSRYENASL 609
Query: 3368 ----EQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILL 3535
E ++ AC AN H FI +LP GY+T VGE+G LSGGQKQR+AIARA++ +P+ILL
Sbjct: 610 EEKFELVKKACVDANAHNFIMKLPQGYDTMVGERGMLLSGGQKQRVAIARAIVSDPRILL 669
Query: 3536 LDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHN 3715
LDEATSALDT+SE VQ ALD A++ RT I +AHRLSTI +A I V+ G+V+EQG+HN
Sbjct: 670 LDEATSALDTQSEGIVQDALDKASRGRTTITIAHRLSTIRDADRIYVMGGGEVLEQGSHN 729
Query: 3716 ELIA-KRGAYFALTQKQSSNQSGGA 3787
+L+A + G Y L Q Q A
Sbjct: 730 DLLANENGPYAQLVNNQKLAQEAAA 754
>gi|4574224|gb|AAD23956.1| multidrug resistance transporter homolog
[Fundulus heteroclitus]
Length = 851
Score = 771 bits (1991), Expect = 0.0
Identities = 420/863 (48%), Positives = 554/863 (63%), Gaps = 18/863 (2%)
Frame = +2
Query: 1229 STIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRS 1408
ST IQLL+RFY+P G + ID I N++YLR ++GVVSQEP LF T+I +NIRYGR
Sbjct: 1 STTIQLLERFYDPQEGSVSIDGHDIRSLNVRYLRGMIGVVSQEPILFATTIAENIRYGRP 60
Query: 1409 DVSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILL 1588
DV++E+I +A KEANA DFI P+ TLVGDRG QMSGGQKQRIAIARALVR PKILL
Sbjct: 61 DVTEEEIEKAAKEANAYDFIMNLPDKFETLVGDRGTQMSGGQKQRIAIARALVRKPKILL 120
Query: 1589 LDEATSALDAESESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHE 1768
LDEATSALDAESE+IVQ+AL+ +GRTT+++AH LST+RNAD I ++ G+V+E+GTH
Sbjct: 121 LDEATSALDAESETIVQAALDKVRQGRTTLIVAHCLSTIRNADVIAGLEKGKVVELGTHS 180
Query: 1769 TLIEQKGLYHELVHAQVFADVDDKPKKKEAE-----------------RRMSRQTSQRKG 1897
L+E+KG+YH LV Q F D+ + RR S + S
Sbjct: 181 ELMEKKGVYHTLVTMQTFQKADEGEDEDNLSAGEKSPIHNNVIESPLLRRKSTRGSSFAA 240
Query: 1898 SVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXGAVKANLFKILRYARPEWIYXX 2077
S+ K + Q ++FK+LR EW Y
Sbjct: 241 SIGEKGDKKQEKEDEDKTEEDEDFPM----------------VSIFKVLRLNASEWPYIL 284
Query: 2078 XXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQ 2257
I GA+ P F++ FS+II VF+ PD+ +++ +F++LMF+V+ V +M Q
Sbjct: 285 VGLICATINGAIQPLFAVLFSKIITVFAEPDQTIIRQRANFFSLMFVVIGVVCFFTMFLQ 344
Query: 2258 CSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRL 2437
FG + E LT+++R ++++LRQD +FD PK+S G +TTRLATDA ++ A RL
Sbjct: 345 GFCFGKSGEVLTLKLRLGAFKSMLRQDLGWFDSPKNSVGALTTRLATDAAQVQGASGVRL 404
Query: 2438 GSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENA 2617
+ IA++G G+ +AF YGW++ L++A+ P +A+ A+ MK G A D KE+E A
Sbjct: 405 ATFAQNIANLGTGVILAFVYGWELTLLILAVVPVIALAGAVQMKMLTGHAAEDKKELEKA 464
Query: 2618 GKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTY 2797
GK A EAIENIRTV +LT + K +++ +L P+ + KA + G T+ F+ ++ +F Y
Sbjct: 465 GKIATEAIENIRTVASLTREPKFESLYEENLVVPYKNSQKKAHVYGFTFSFSQAMIYFAY 524
Query: 2798 AAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNM 2977
AA FRFG +LI + M+ E V V+ A+ F +G A S+ P Y KA +A + +
Sbjct: 525 AACFRFGAWLIVEGR--MDVEAVFLVISAVLFGAMAVGEANSFAPNYAKAKMSASHLMML 582
Query: 2978 LEEEPRIDGMTSSGTYPQL-SGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGP 3154
L +EP ID ++ G P + G V V F YP RP VPIL+GLN+ VK G+TLALVG
Sbjct: 583 LNKEPEIDNLSERGESPDMFDGNVSFEDVKFNYPSRPDVPILRGLNLRVKKGETLALVGS 642
Query: 3155 SGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENI 3334
SGCGKST I LLER YDP +G V +D+ D++++N LR I +VSQEP+LFD ++ ENI
Sbjct: 643 SGCGKSTTIQLLERFYDPRDGRVVMDSIDVKRLNIHWLRSQIGIVSQEPVLFDCALAENI 702
Query: 3335 VYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALI 3514
YG T E+IE A ANIH FI+ELP Y T+ G+KGTQLSGGQKQRIAIARA++
Sbjct: 703 AYGDNSRSVTMEEIEAAAKAANIHNFINELPQKYNTQAGDKGTQLSGGQKQRIAIARAIL 762
Query: 3515 RNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQV 3694
RNPK+LLLDEATSALDTESEK VQ ALD A+K RTCIVVAHRLSTI NA I V + G V
Sbjct: 763 RNPKVLLLDEATSALDTESEKVVQDALDQASKGRTCIVVAHRLSTIRNADRIAVFQGGVV 822
Query: 3695 VEQGTHNELIAKRGAYFALTQKQ 3763
VEQGTH +L+AK+G Y L Q
Sbjct: 823 VEQGTHQQLLAKKGVYHMLVTTQ 845
Score = 405 bits (1041), Expect = e-111
Identities = 234/597 (39%), Positives = 351/597 (58%), Gaps = 4/597 (0%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+SIF++ R ++ +L VG+I + G PL +++ + T+F +P+ T
Sbjct: 267 VSIFKVLRLNASEWPYIL-VGLICATINGAIQPLFAVLFSKII-------TVFAEPDQTI 318
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
+ RA F L +V +G F FLQ CF E L+ + R F S++R
Sbjct: 319 IRQ---RANFFS------LMFVVIGVVCFFTMFLQGFCFGKSGEVLTLKLRLGAFKSMLR 369
Query: 401 QEIAWYD--KNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLT 574
Q++ W+D KN+ G L+ +L + +V+ +G ++ Q +A G +AF Y W LT
Sbjct: 370 QDLGWFDSPKNSVGALTTRLATDAAQVQGASGVRLATFAQNIANLGTGVILAFVYGWELT 429
Query: 575 LIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECK 754
L+++++ P + + G + AG IA E + +IRTV + +
Sbjct: 430 LLILAVVPVIALAGAVQMKMLTGHAAEDKKELEKAGKIATEAIENIRTVASLTREPKFES 489
Query: 755 RYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVF 934
YE+ L K KK+ + G + +IY +Y F G + GR++ V V
Sbjct: 490 LYEENLVVPYKNSQKKAHVYGFTFSFSQAMIYFAYAACFRFGAWLIVEGRMDVEAVFLVI 549
Query: 935 FSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVN 1114
+V+ G+MA+G+A A +A+ L ++++ PEID S G++P G +S
Sbjct: 550 SAVLFGAMAVGEANSFAPNYAKAKMSASHLMMLLNKEPEIDNLSERGESPDMFDGNVSFE 609
Query: 1115 KVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDD 1294
V+F YP+R DV IL+G++L + G+T+ALVGSSGCGKST IQLL+RFY+P G++++D
Sbjct: 610 DVKFNYPSRPDVPILRGLNLRVKKGETLALVGSSGCGKSTTIQLLERFYDPRDGRVVMDS 669
Query: 1295 IPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRS--DVSDEDIARALKEANAADFI 1468
I ++ NI +LR +G+VSQEP LF+ ++ +NI YG + V+ E+I A K AN +FI
Sbjct: 670 IDVKRLNIHWLRSQIGIVSQEPVLFDCALAENIAYGDNSRSVTMEEIEAAAKAANIHNFI 729
Query: 1469 KTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSAL 1648
P+ NT GD+G Q+SGGQKQRIAIARA++RNPK+LLLDEATSALD ESE +VQ AL
Sbjct: 730 NELPQKYNTQAGDKGTQLSGGQKQRIAIARAILRNPKVLLLDEATSALDTESEKVVQDAL 789
Query: 1649 ENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQV 1819
+ AS+GRT IV+AHRLST+RNAD+I V + G V+E GTH+ L+ +KG+YH LV Q+
Sbjct: 790 DQASKGRTCIVVAHRLSTIRNADRIAVFQGGVVVEQGTHQQLLAKKGVYHMLVTTQL 846
Score = 220 bits (560), Expect = 2e-55
Identities = 117/199 (58%), Positives = 146/199 (72%)
Frame = +2
Query: 3170 STVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQ 3349
ST I LLER YDP EG+V++D +D+R +N ++LR I +VSQEPILF T+I ENI YG
Sbjct: 1 STTIQLLERFYDPQEGSVSIDGHDIRSLNVRYLRGMIGVVSQEPILFATTIAENIRYGRP 60
Query: 3350 PGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKI 3529
+ T E+IE A +AN + FI LPD +ET VG++GTQ+SGGQKQRIAIARAL+R PKI
Sbjct: 61 --DVTEEEIEKAAKEANAYDFIMNLPDKFETLVGDRGTQMSGGQKQRIAIARALVRKPKI 118
Query: 3530 LLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGT 3709
LLLDEATSALD ESE VQ ALD + RT ++VAH LSTI NA I ++ G+VVE GT
Sbjct: 119 LLLDEATSALDAESETIVQAALDKVRQGRTTLIVAHCLSTIRNADVIAGLEKGKVVELGT 178
Query: 3710 HNELIAKRGAYFALTQKQS 3766
H+EL+ K+G Y L Q+
Sbjct: 179 HSELMEKKGVYHTLVTMQT 197
>gi|34911450|ref|NP_917072.1| putative multidrug resistance protein 1
homolog [Oryza sativa (japonica cultivar-group)]
gi|22535536|dbj|BAC10713.1| putative multidrug resistance protein 1
homolog [Oryza sativa (japonica cultivar-group)]
Length = 1265
Score = 766 bits (1978), Expect = 0.0
Identities = 450/1247 (36%), Positives = 685/1247 (54%), Gaps = 16/1247 (1%)
Frame = +2
Query: 56 LYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAA 235
++RY VD+ ++AVG + + A G+ PLM+++ V F D ST +
Sbjct: 35 MFRYADGVDKALMAVGTVAAMANGMSEPLMTVVFSAVIDCFGG------DDVSTVLHR-- 86
Query: 236 ARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAW 415
+ L +V L +F Q SC+ + E+ S R + +++ Q+IA+
Sbjct: 87 ---------VSKVLSHV-LWLSLFVVVSNQVSCWTMAGERQSACIRSLYLEAIITQDIAF 136
Query: 416 YD-KNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSL 592
+D + T+G ++++ + +++ G+KVG Q++ F+GGF + F W+L L++M+
Sbjct: 137 FDVEMTTGEAASRISADTVLIQDALGEKVGKYIQVLTAFVGGFVIGFIRGWMLALVVMAC 196
Query: 593 SPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDAL 772
P + Y+ AG + E+ + SIR V++FNG++ Y +
Sbjct: 197 IPPSIFSFALVSRLRAQISGKTHVSYSYAGNVVEQTIGSIRMVVSFNGEKRAITMYNTLI 256
Query: 773 EHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMG 952
+ K I + + G G+ S F ++Y SY LAFW G V S G V+ V F+++ G
Sbjct: 257 KKAYKATIMEGIISGFGIGSIFFVVYCSYSLAFWYGAKLVISKGYTGGQVINVVFAILTG 316
Query: 953 SMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTY 1132
SMA+G A + I AA L+E+I+R P ID T G I G + + V F+Y
Sbjct: 317 SMAIGNASPSISAIAEGQSAAHRLFEIINRKPNIDITGTSGIILEDIKGNVELKDVCFSY 376
Query: 1133 PTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDF 1312
P R + IL G+ L G T+A+VG SG GKSTII L++RFY+P G++LID I I+
Sbjct: 377 PARPEQLILDGLCLQVPNGTTMAIVGQSGSGKSTIISLVERFYDPQDGEVLIDGINIKTL 436
Query: 1313 NIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEGLN 1492
+ ++R + +VSQEP LF TSI+ NI YG+ + +DE+I RA + ANAA+FI P +
Sbjct: 437 KLHWIRGKMSLVSQEPLLFMTSIKDNITYGKENATDEEIKRAAELANAANFIDKLPNAYD 496
Query: 1493 TLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRT 1672
T+VG G Q+SGGQKQRIAIARA+++NPK+LLLDEATSALD ESE +VQ AL GRT
Sbjct: 497 TMVGQHGAQLSGGQKQRIAIARAILKNPKVLLLDEATSALDVESERLVQEALNRVMIGRT 556
Query: 1673 TIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLI-EQKGLYHELV-----HAQVFADVD 1834
T+++AHRLST++NAD I V+ G++++ G+H+ LI + G Y +L+ H + DV
Sbjct: 557 TLIVAHRLSTIKNADCIAVVHQGKIVDQGSHDELIKDPDGAYSQLIQLQQTHTEEMHDV- 615
Query: 1835 DKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXX----- 1999
+ + R SR S + +N + + +
Sbjct: 616 -QYSEVSTSRLKSRSLSLEQSMINDSPRNRRKNSLAKHIGSSGSDGLHKHGLTDEPEDKE 674
Query: 2000 -XXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRD 2176
KA + ++ +PE + G + P FS+ S I F P
Sbjct: 675 CGDNKDINKAPIRRLFNLNKPEAPILLLAIITAFVHGLLFPIFSIMMSGGIRTFYYPPH- 733
Query: 2177 QMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDM 2356
Q++KD FWALM +++A + S+ + LFG+A +L R+R +++++ Q+ ++FD
Sbjct: 734 QLRKDSRFWALMCILMAIISLVSIQLEYFLFGMAGGKLIERVRCLSFQSIVHQEVSWFDD 793
Query: 2357 PKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFP 2536
P HS G + +L DA NI+ + L + I ++ G IAF W++ +M P
Sbjct: 794 PSHSSGSLGAKLYIDALNIRRLVGDNLAILVQCIVTLIAGFTIAFASDWKLTLTIMCPIP 853
Query: 2537 FMAVGQALMMKYHGGSATSDAKEM-ENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLD 2713
+ + + +K+ G + DAK M E+A + EAI +IRTV + + ++ +
Sbjct: 854 LVGLQNYVQLKFLKG-FSEDAKVMYEDASQVVTEAIGSIRTVASFCAEKRVIKTYNQKCQ 912
Query: 2714 APHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGL-FLIFDKNVLMEPENVLRVLFAIS 2890
A +I ++ GL + F+ + + TYA F G F+ K+ ++V RV FA+
Sbjct: 913 ASMKESIRSGMVGGLGFSFSYLMVYLTYALCFYVGAQFVHGGKSTF---KDVFRVYFALV 969
Query: 2891 FSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSG-TYPQLSGEVKLNKVFF 3067
F+ I ++ + KA +A I +++ + ID G +++G ++LN V F
Sbjct: 970 FTAFGISQTSAMASDSSKAHESAASILAIIDRKSNIDSSIDEGIILEKVNGTIELNHVNF 1029
Query: 3068 RYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLR 3247
+YP RP V +L + + G+T+ALVG SG GKSTVI+LLER YDP G +++D +L+
Sbjct: 1030 KYPSRPDVQVLCDFTLGIPSGKTVALVGESGSGKSTVIALLERFYDPHSGTISLDRVELK 1089
Query: 3248 QMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELP 3427
+ LR + LVSQEPILF+ +I NI YG + G+ T E+I +N H+FI LP
Sbjct: 1090 NLKLSWLRDQMGLVSQEPILFNDTIHANIAYG-RKGQVTEEEIIAVAKASNAHEFISSLP 1148
Query: 3428 DGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAA 3607
GY T VGE+GTQLSGGQKQRIAIARA++++PKILLLDEATSALD ESE+ VQ ALD
Sbjct: 1149 QGYNTTVGERGTQLSGGQKQRIAIARAILKDPKILLLDEATSALDAESERIVQDALDQVM 1208
Query: 3608 KDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFA 3748
RT IVVAHRLSTI A I V+K+G + E+G H+ L+ G +A
Sbjct: 1209 VSRTTIVVAHRLSTIKGADVIAVIKDGSIAEKGQHDSLMRINGGVYA 1255
Score = 369 bits (946), Expect = e-100
Identities = 201/489 (41%), Positives = 292/489 (59%), Gaps = 4/489 (0%)
Frame = +2
Query: 353 KLSNRFRRQFFHSVMRQEIAWYD--KNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQ 526
KL R R F S++ QE++W+D ++SG+L KL+ + +R GD + + Q +
Sbjct: 770 KLIERVRCLSFQSIVHQEVSWFDDPSHSSGSLGAKLYIDALNIRRLVGDNLAILVQCIVT 829
Query: 527 FIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLT 706
I GF +AF DW LTL +M P + + Y A + E +
Sbjct: 830 LIAGFTIAFASDWKLTLTIMCPIPLVGLQNYVQLKFLKGFSEDAKVMYEDASQVVTEAIG 889
Query: 707 SIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTN 886
SIRTV +F ++ K Y + K I+ + G G + ++++Y +Y L F+VG
Sbjct: 890 SIRTVASFCAEKRVIKTYNQKCQASMKESIRSGMVGGLGFSFSYLMVYLTYALCFYVGAQ 949
Query: 887 FVYSGRLESGTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYS 1066
FV+ G+ V V+F+++ + + Q + A +AAS+ +IDR ID+
Sbjct: 950 FVHGGKSTFKDVFRVYFALVFTAFGISQTSAMASDSSKAHESAASILAIIDRKSNIDSSI 1009
Query: 1067 TEGQTPSKISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQL 1246
EG K++G I +N V F YP+R DV++L +L G+TVALVG SG GKST+I L
Sbjct: 1010 DEGIILEKVNGTIELNHVNFKYPSRPDVQVLCDFTLGIPSGKTVALVGESGSGKSTVIAL 1069
Query: 1247 LQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGR-SDVSDE 1423
L+RFY+P +G I +D + +++ + +LR +G+VSQEP LFN +I NI YGR V++E
Sbjct: 1070 LERFYDPHSGTISLDRVELKNLKLSWLRDQMGLVSQEPILFNDTIHANIAYGRKGQVTEE 1129
Query: 1424 DIARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEAT 1603
+I K +NA +FI + P+G NT VG+RG Q+SGGQKQRIAIARA++++PKILLLDEAT
Sbjct: 1130 EIIAVAKASNAHEFISSLPQGYNTTVGERGTQLSGGQKQRIAIARAILKDPKILLLDEAT 1189
Query: 1604 SALDAESESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIE- 1780
SALDAESE IVQ AL+ RTTIV+AHRLST++ AD I V+K G + E G H++L+
Sbjct: 1190 SALDAESERIVQDALDQVMVSRTTIVVAHRLSTIKGADVIAVIKDGSIAEKGQHDSLMRI 1249
Query: 1781 QKGLYHELV 1807
G+Y LV
Sbjct: 1250 NGGVYASLV 1258
Score = 333 bits (853), Expect = 2e-89
Identities = 210/567 (37%), Positives = 311/567 (54%), Gaps = 8/567 (1%)
Frame = +2
Query: 2096 LIQGAVMPAFSLFFSQIINVFSNPDRDQM-----KKDGH-FWALMFLVLAAVQGTSMLFQ 2257
+ G P ++ FS +I+ F D + K H W +F+V++ Q
Sbjct: 55 MANGMSEPLMTVVFSAVIDCFGGDDVSTVLHRVSKVLSHVLWLSLFVVVSN--------Q 106
Query: 2258 CSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRL 2437
S + +A ER + IRS ++ QD +FD+ + + G +R++ D I+ A+ ++
Sbjct: 107 VSCWTMAGERQSACIRSLYLEAIITQDIAFFDV-EMTTGEAASRISADTVLIQDALGEKV 165
Query: 2438 GSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENA 2617
G + + GG I F GW +A +VMA P AL+ + + A
Sbjct: 166 GKYIQVLTAFVGGFVIGFIRGWMLALVVMACIPPSIFSFALVSRLRAQISGKTHVSYSYA 225
Query: 2618 GKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTY 2797
G + I +IR V + + + ++ + + + I + II G G + + +Y
Sbjct: 226 GNVVEQTIGSIRMVVSFNGEKRAITMYNTLIKKAYKATIMEGIISGFGIGSIFFVVYCSY 285
Query: 2798 AAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNM 2977
+ AF +G L+ K V+ V+FAI IG A+ + AA +F +
Sbjct: 286 SLAFWYGAKLVISKGYT--GGQVINVVFAILTGSMAIGNASPSISAIAEGQSAAHRLFEI 343
Query: 2978 LEEEPRIDGMTSSGTYPQ-LSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGP 3154
+ +P ID +SG + + G V+L V F YP RP IL GL + V G T+A+VG
Sbjct: 344 INRKPNIDITGTSGIILEDIKGNVELKDVCFSYPARPEQLILDGLCLQVPNGTTMAIVGQ 403
Query: 3155 SGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENI 3334
SG GKST+ISL+ER YDP +G V +D +++ + +R ++LVSQEP+LF TSI++NI
Sbjct: 404 SGSGKSTIISLVERFYDPQDGEVLIDGINIKTLKLHWIRGKMSLVSQEPLLFMTSIKDNI 463
Query: 3335 VYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALI 3514
YG + T E+I+ A AN FID+LP+ Y+T VG+ G QLSGGQKQRIAIARA++
Sbjct: 464 TYGKENA--TDEEIKRAAELANAANFIDKLPNAYDTMVGQHGAQLSGGQKQRIAIARAIL 521
Query: 3515 RNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQV 3694
+NPK+LLLDEATSALD ESE+ VQ AL+ RT ++VAHRLSTI NA CI VV G++
Sbjct: 522 KNPKVLLLDEATSALDVESERLVQEALNRVMIGRTTLIVAHRLSTIKNADCIAVVHQGKI 581
Query: 3695 VEQGTHNELIA-KRGAYFALTQKQSSN 3772
V+QG+H+ELI GAY L Q Q ++
Sbjct: 582 VDQGSHDELIKDPDGAYSQLIQLQQTH 608
>gi|15228052|ref|NP_181228.1| multidrug resistance P-glycoprotein
(PGP1) [Arabidopsis thaliana]
gi|419760|pir||A42150 P-glycoprotein pgp1 - Arabidopsis thaliana
gi|3849833|emb|CAA43646.1| P-glycoprotein [Arabidopsis thaliana]
gi|4883607|gb|AAD31576.1| putative ABC transporter [Arabidopsis
thaliana]
Length = 1286
Score = 764 bits (1974), Expect = 0.0
Identities = 448/1261 (35%), Positives = 682/1261 (53%), Gaps = 20/1261 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
++ +L+R+ +D +++ +G + + G LPL ++ +F + NS
Sbjct: 27 VAFKELFRFADGLDYVLMGIGSVGAFVHGCSLPLFLRFFADLVNSFGS--------NSNN 78
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
EK EV++ L ++ +G I+A+ + + SC+M E+ + + R ++ + +
Sbjct: 79 VEK------MMEEVLKYALYFLVVGAAIWASSWAEISCWMWSGERQTTKMRIKYLEAALN 132
Query: 401 QEIAWYDKNTSGTLSNKLF---DNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLL 571
Q+I ++D T S+ +F + V++ +K+G MA F+ GF V FT W L
Sbjct: 133 QDIQFFD--TEVRTSDVVFAINTDAVMVQDAISEKLGNFIHYMATFVSGFIVGFTAVWQL 190
Query: 572 TLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYEC 751
L+ +++ P + + G + AG I E+ + IR V+AF G+
Sbjct: 191 ALVTLAVVPLIAVIGGIHTTTLSKLSNKSQESLSQAGNIVEQTVVQIRVVMAFVGESRAS 250
Query: 752 KRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTV 931
+ Y AL+ +K G K G GL + + +++ Y L W G V G +
Sbjct: 251 QAYSSALKIAQKLGYKTGLAKGMGLGATYFVVFCCYALLLWYGGYLVRHHLTNGGLAIAT 310
Query: 932 FFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISV 1111
F+VM+G +ALGQ+ A A AAA ++ +ID P I+ S G ++G + +
Sbjct: 311 MFAVMIGGLALGQSAPSMAAFAKAKVAAAKIFRIIDHKPTIERNSESGVELDSVTGLVEL 370
Query: 1112 NKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILID 1291
V+F+YP+R DVKIL L G+T+ALVGSSG GKST++ L++RFY+P++GQ+L+D
Sbjct: 371 KNVDFSYPSRPDVKILNNFCLSVPAGKTIALVGSSGSGKSTVVSLIERFYDPNSGQVLLD 430
Query: 1292 DIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIK 1471
++ +++LRQ +G+VSQEP LF TSI++NI GR D +I A + ANA FI
Sbjct: 431 GQDLKTLKLRWLRQQIGLVSQEPALFATSIKENILLGRPDADQVEIEEAARVANAHSFII 490
Query: 1472 TFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALE 1651
P+G +T VG+RG+Q+SGGQKQRIAIARA+++NP ILLLDEATSALD+ESE +VQ AL+
Sbjct: 491 KLPDGFDTQVGERGLQLSGGQKQRIAIARAMLKNPAILLLDEATSALDSESEKLVQEALD 550
Query: 1652 NASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIE--QKGLYHELVHAQVFA 1825
GRTT++IAHRLST+R AD + V++ G V E+GTH+ L + G+Y +L+ Q A
Sbjct: 551 RFMIGRTTLIIAHRLSTIRKADLVAVLQQGSVSEIGTHDELFSKGENGVYAKLIKMQEAA 610
Query: 1826 DV-------DDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXX 1984
+ A +S R S ++
Sbjct: 611 HETAMSNARKSSARPSSARNSVSSPIMTRNSSYGRSPYSRRLSDFSTSDFSLSIDASSYP 670
Query: 1985 XXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSN 2164
+ +++ + PEW Y +I G++ F+ S +++V+ N
Sbjct: 671 NYRNEKLAFKDQANSFWRLAKMNSPEWKYALLGSVGSVICGSLSAFFAYVLSAVLSVYYN 730
Query: 2165 PDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDAT 2344
PD + M K + + + L++ Q S + + E LT R+R K+ VL+ +
Sbjct: 731 PDHEYMIKQIDKYCYLLIGLSSAALVFNTLQHSFWDIVGENLTKRVREKMLSAVLKNEMA 790
Query: 2345 YFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVM 2524
+FD ++ RI RLA DA N++SAI R+ I A + F W++A +++
Sbjct: 791 WFDQEENESARIAARLALDANNVRSAIGDRISVIVQNTALMLVACTAGFVLQWRLALVLV 850
Query: 2525 AIFPFMAVGQAL----MMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYN 2692
A+FP + L M + G + AK + AG EAI N+RTV A + K+
Sbjct: 851 AVFPVVVAATVLQKMFMTGFSGDLEAAHAKGTQLAG----EAIANVRTVAAFNSEAKIVR 906
Query: 2693 IFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLR 2872
++ ++L+ P K I G YG A + +YA + +L+ K+ + + +R
Sbjct: 907 LYTANLEPPLKRCFWKGQIAGSGYGVAQFCLYASYALGLWYASWLV--KHGISDFSKTIR 964
Query: 2873 VLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRI--DGMTSSGTYPQLSGEV 3046
V + S + P++IK A +F +L+ + I D ++ +L GEV
Sbjct: 965 VFMVLMVSANGAAETLTLAPDFIKGGQAMRSVFELLDRKTEIEPDDPDTTPVPDRLRGEV 1024
Query: 3047 KLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVT 3226
+L + F YP RP + I + L++ + G+TLALVGPSGCGKS+VISL++R Y+P G V
Sbjct: 1025 ELKHIDFSYPSRPDIQIFRDLSLRARAGKTLALVGPSGCGKSSVISLIQRFYEPSSGRVM 1084
Query: 3227 VDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIH 3406
+D D+R+ N K +RKHIA+V QEP LF T+I ENI YG + T +I A + A+ H
Sbjct: 1085 IDGKDIRKYNLKAIRKHIAIVPQEPCLFGTTIYENIAYGHECA--TEAEIIQAATLASAH 1142
Query: 3407 KFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQ 3586
KFI LP+GY+T VGE+G QLSGGQKQRIAIARAL+R +I+LLDEATSALD ESE+ VQ
Sbjct: 1143 KFISALPEGYKTYVGERGVQLSGGQKQRIAIARALVRKAEIMLLDEATSALDAESERSVQ 1202
Query: 3587 VALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKR--GAYFALTQK 3760
ALD A RT IVVAHRLSTI NA I V+ +G+V EQG+H+ L+ G Y + Q
Sbjct: 1203 EALDQACSGRTSIVVAHRLSTIRNAHVIAVIDDGKVAEQGSHSHLLKNHPDGIYARMIQL 1262
Query: 3761 Q 3763
Q
Sbjct: 1263 Q 1263
Score = 340 bits (872), Expect = 2e-91
Identities = 198/536 (36%), Positives = 304/536 (55%), Gaps = 13/536 (2%)
Frame = +2
Query: 254 HE-VIQNCLKYVYLGCGIFAAGF----LQASCFMVICEKLSNRFRRQFFHSVMRQEIAWY 418
HE +I+ KY YL G+ +A LQ S + ++ E L+ R R + +V++ E+AW+
Sbjct: 733 HEYMIKQIDKYCYLLIGLSSAALVFNTLQHSFWDIVGENLTKRVREKMLSAVLKNEMAWF 792
Query: 419 DK--NTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSL 592
D+ N S ++ +L + VR GD++ + Q A + F W L L+++++
Sbjct: 793 DQEENESARIAARLALDANNVRSAIGDRISVIVQNTALMLVACTAGFVLQWRLALVLVAV 852
Query: 593 SPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDAL 772
P ++ + +A +A E + ++RTV AFN + + Y L
Sbjct: 853 FPVVVAATVLQKMFMTGFSGDLEAAHAKGTQLAGEAIANVRTVAAFNSEAKIVRLYTANL 912
Query: 773 EHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMG 952
E K K + G+G +YASY L W + V G + + VF +M+
Sbjct: 913 EPPLKRCFWKGQIAGSGYGVAQFCLYASYALGLWYASWLVKHGISDFSKTIRVFMVLMVS 972
Query: 953 SMALGQA---GQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQ-TPSKISGRISVNKV 1120
+ + F G A+ S++E++DR EI+ + P ++ G + + +
Sbjct: 973 ANGAAETLTLAPDFIKGGQAM---RSVFELLDRKTEIEPDDPDTTPVPDRLRGEVELKHI 1029
Query: 1121 EFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIP 1300
+F+YP+R D++I + +SL A+ G+T+ALVG SGCGKS++I L+QRFY P +G+++ID
Sbjct: 1030 DFSYPSRPDIQIFRDLSLRARAGKTLALVGPSGCGKSSVISLIQRFYEPSSGRVMIDGKD 1089
Query: 1301 IEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFP 1480
I +N+K +R+ + +V QEP LF T+I +NI YG ++ +I +A A+A FI P
Sbjct: 1090 IRKYNLKAIRKHIAIVPQEPCLFGTTIYENIAYGHECATEAEIIQAATLASAHKFISALP 1149
Query: 1481 EGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENAS 1660
EG T VG+RGVQ+SGGQKQRIAIARALVR +I+LLDEATSALDAESE VQ AL+ A
Sbjct: 1150 EGYKTYVGERGVQLSGGQKQRIAIARALVRKAEIMLLDEATSALDAESERSVQEALDQAC 1209
Query: 1661 RGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQ--KGLYHELVHAQVF 1822
GRT+IV+AHRLST+RNA I V+ G+V E G+H L++ G+Y ++ Q F
Sbjct: 1210 SGRTSIVVAHRLSTIRNAHVIAVIDDGKVAEQGSHSHLLKNHPDGIYARMIQLQRF 1265
Score = 339 bits (869), Expect = 3e-91
Identities = 208/562 (37%), Positives = 309/562 (54%), Gaps = 5/562 (0%)
Frame = +2
Query: 2099 IQGAVMPAFSLFFSQIINVFSNPDR--DQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFG 2272
+ G +P F FF+ ++N F + ++M ++ +AL FLV+ A S + S +
Sbjct: 53 VHGCSLPLFLRFFADLVNSFGSNSNNVEKMMEEVLKYALYFLVVGAAIWASSWAEISCWM 112
Query: 2273 VAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFN 2452
+ ER T ++R K L QD +FD + + + TDA ++ AI +LG+ +
Sbjct: 113 WSGERQTTKMRIKYLEAALNQDIQFFDTEVRTSD-VVFAINTDAVMVQDAISEKLGNFIH 171
Query: 2453 AIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAM 2632
+A+ G + F WQ+A + +A+ P +AV + + + + AG
Sbjct: 172 YMATFVSGFIVGFTAVWQLALVTLAVVPLIAVIGGIHTTTLSKLSNKSQESLSQAGNIVE 231
Query: 2633 EAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFR 2812
+ + IR V A +++ + S L + +G+ G + F YA
Sbjct: 232 QTVVQIRVVMAFVGESRASQAYSSALKIAQKLGYKTGLAKGMGLGATYFVVFCCYALLLW 291
Query: 2813 FGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEP 2992
+G +L+ ++ L + +FA+ +G +A + KA AA IF +++ +P
Sbjct: 292 YGGYLV--RHHLTNGGLAIATMFAVMIGGLALGQSAPSMAAFAKAKVAAAKIFRIIDHKP 349
Query: 2993 RIDGMTSSGT-YPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGK 3169
I+ + SG ++G V+L V F YP RP V IL + V G+T+ALVG SG GK
Sbjct: 350 TIERNSESGVELDSVTGLVELKNVDFSYPSRPDVKILNNFCLSVPAGKTIALVGSSGSGK 409
Query: 3170 STVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQ 3349
STV+SL+ER YDP G V +D DL+ + + LR+ I LVSQEP LF TSI+ENI+ G
Sbjct: 410 STVVSLIERFYDPNSGQVLLDGQDLKTLKLRWLRQQIGLVSQEPALFATSIKENILLGRP 469
Query: 3350 PGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKI 3529
+ +IE A AN H FI +LPDG++T+VGE+G QLSGGQKQRIAIARA+++NP I
Sbjct: 470 DADQV--EIEEAARVANAHSFIIKLPDGFDTQVGERGLQLSGGQKQRIAIARAMLKNPAI 527
Query: 3530 LLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGT 3709
LLLDEATSALD+ESEK VQ ALD RT +++AHRLSTI A + V++ G V E GT
Sbjct: 528 LLLDEATSALDSESEKLVQEALDRFMIGRTTLIIAHRLSTIRKADLVAVLQQGSVSEIGT 587
Query: 3710 HNELIAK--RGAYFALTQKQSS 3769
H+EL +K G Y L + Q +
Sbjct: 588 HDELFSKGENGVYAKLIKMQEA 609
>gi|7442651|pir||T14805 hypothetical protein F15J5.20 - Arabidopsis
thaliana
gi|5816991|emb|CAB53646.1| multidrug resistance
protein/P-glycoprotein-like [Arabidopsis thaliana]
Length = 1222
Score = 764 bits (1973), Expect = 0.0
Identities = 454/1229 (36%), Positives = 672/1229 (53%), Gaps = 43/1229 (3%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+S F+L+ + D +++ VG I + G+ P M++I G + F T DP+
Sbjct: 16 VSFFKLFSFADKTDVVLMTVGTIAAAGNGLTQPFMTLIFGQLINAFGTT-----DPDHMV 70
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
EV + +K++YL FLQ SC+MV E+ S R + +++R
Sbjct: 71 -----------REVWKVAVKFIYLAVYSCVVAFLQVSCWMVTGERQSATIRGLYLKTILR 119
Query: 401 QEIAWYDKNTS-GTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
Q+I ++D T+ G + ++ + +++ G+KVG Q++ F+GGFA+AF LL
Sbjct: 120 QDIGYFDTETNTGEVIGRMSGDTILIQDAMGEKVGKFTQLLCTFLGGFAIAFYKGPLLAG 179
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
++ S P ++I G YA AG + E+ + +IRTV+AF G++ ++
Sbjct: 180 VLCSCIPLIVIAGAAMSLIMSKMAGRGQVAYAEAGNVVEQTVGAIRTVVAFTGEKQATEK 239
Query: 758 YEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFF 937
YE LE KT +++ + G GL + +I+ SY LA W G + G V+ V F
Sbjct: 240 YESKLEIAYKTVVQQGLISGFGLGTMLAVIFCSYGLAVWYGAKLIMEKGYNGGQVINVIF 299
Query: 938 SVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNK 1117
+V+ G M+LGQ AA ++E I R P+IDAY G I G I +
Sbjct: 300 AVLTGGMSLGQTSPSLNAFAAGRAAAFKMFETIKRSPKIDAYDMSGSVLEDIRGDIELKD 359
Query: 1118 VEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDI 1297
V F YP R DV+I G SL G+TVALVG SG GKST+I L++RFY+P++GQ+LID+I
Sbjct: 360 VYFRYPARPDVQIFAGFSLFVPNGKTVALVGQSGSGKSTVISLIERFYDPESGQVLIDNI 419
Query: 1298 PIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTF 1477
++ +K++R +G+VSQEP LF T+I++NI YG+ D +D++I A++ ANAA FI
Sbjct: 420 DLKKLQLKWIRSKIGLVSQEPVLFATTIKENIAYGKEDATDQEIRTAIELANAAKFIDKL 479
Query: 1478 PEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENA 1657
P+GL+T+VG+ G QMSGGQKQR+AIARA+++NPKILLLDEATSALDAESE IVQ AL N
Sbjct: 480 PQGLDTMVGEHGTQMSGGQKQRLAIARAILKNPKILLLDEATSALDAESERIVQDALVNL 539
Query: 1658 SRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQ-KGLYHELVHAQVFADVD 1834
RTT+V+AHRL+T+R AD I V+ G+++E GTH+ +I+ +G Y +LV Q
Sbjct: 540 MSNRTTVVVAHRLTTIRTADVIAVVHQGKIVEKGTHDEMIQDPEGAYSQLVRLQ----EG 595
Query: 1835 DKPKKKEAERRMSRQTSQRKGSVNFKT-QESQVDXXXXXXXXXXXXXXXXXXXXXXXXXX 2011
K + E+ER + +R GS+ + V
Sbjct: 596 SKEEATESERPETSLDVERSGSLRLSSAMRRSVSRNSSSSRHSFSLASNMFFPGVNVNQT 655
Query: 2012 GAV----------KANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFS 2161
+ K +L ++ +PE ++ G V P F L S IN+F
Sbjct: 656 DEMEDEENNVRHKKVSLKRLAHLNKPEIPVLVLGSIAAMVHGTVFPIFGLLLSSSINMFY 715
Query: 2162 NPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDA 2341
P + +KKD HFWAL+++ L + FG+A +L RIRS + V+ Q+
Sbjct: 716 EPAK-ILKKDSHFWALIYIALGLTNFVMIPVPNYFFGIAGGKLIKRIRSMCFDKVVHQEI 774
Query: 2342 TYFDMPKHS---------------------------PGRITTRLATDAPNIKSAIDYRLG 2440
++FD +S P R+ +TDA ++S + L
Sbjct: 775 SWFDDTANSRYYNFIYIINRRILYVLILIFICVLLPPVRLERECSTDASTVRSLVGDALA 834
Query: 2441 SIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEM-ENA 2617
I IA+V GL IAF W +A +V+A+ PF+ + K+ G ++DAK M E A
Sbjct: 835 LIVQNIATVTTGLIIAFTANWILALIVLALSPFIVIQGYAQTKFLTG-FSADAKAMYEEA 893
Query: 2618 GKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTY 2797
+ A +A+ +IRTV + + K+ +++ D P + ++ G +GF+ +
Sbjct: 894 SQVANDAVSSIRTVASFCAEEKVMDLYQQKCDGPKKNGVRLGLLSGAGFGFSFFFLYCIN 953
Query: 2798 AAAFRFGLFLI-FDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFN 2974
F G LI K E V +V FA++ + ++ P+ KA +A IF+
Sbjct: 954 CVCFVSGAGLIQIGKATFGE---VFKVFFALTIMAIGVSQTSAMAPDSNKAKDSAASIFD 1010
Query: 2975 MLEEEPRIDGMTSSGTYPQ-LSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVG 3151
+L+ P+ID + GT Q ++G+++ V FRYP RP V I + L + + G+T+ALVG
Sbjct: 1011 ILDSTPKIDSSSDEGTTLQNVNGDIEFRHVSFRYPMRPDVQIFRDLCLTIPSGKTVALVG 1070
Query: 3152 PSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIREN 3331
SG GKSTVIS++ER Y+P G + +D +++ LR+ + LVSQEPILF+ +IR N
Sbjct: 1071 ESGSGKSTVISMIERFYNPDSGKILIDQVEIQTFKLSWLRQQMGLVSQEPILFNETIRSN 1130
Query: 3332 IVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARAL 3511
I YG + G T E+I A AN H FI LP GY+T VGE+G QLSGGQKQRIAIARA+
Sbjct: 1131 IAYG-KTGGATEEEIIAAAKAANAHNFISSLPQGYDTSVGERGVQLSGGQKQRIAIARAI 1189
Query: 3512 IRNPKILLLDEATSALDTESEKQVQVALD 3598
+++PKILLLDEATSALD ESE+ VQ ALD
Sbjct: 1190 LKDPKILLLDEATSALDAESERVVQDALD 1218
Score = 365 bits (937), Expect = 5e-99
Identities = 224/591 (37%), Positives = 326/591 (54%), Gaps = 3/591 (0%)
Frame = +2
Query: 2012 GAVKANLFKILRYA-RPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKK 2188
G K + FK+ +A + + + G P +L F Q+IN F D D M +
Sbjct: 12 GNQKVSFFKLFSFADKTDVVLMTVGTIAAAGNGLTQPFMTLIFGQLINAFGTTDPDHMVR 71
Query: 2189 DGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHS 2368
+ A+ F+ LA Q S + V ER + IR + +LRQD YFD ++
Sbjct: 72 EVWKVAVKFIYLAVYSCVVAFLQVSCWMVTGERQSATIRGLYLKTILRQDIGYFDTETNT 131
Query: 2369 PGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAV 2548
G + R++ D I+ A+ ++G + + GG IAFY G +A ++ + P + +
Sbjct: 132 -GEVIGRMSGDTILIQDAMGEKVGKFTQLLCTFLGGFAIAFYKGPLLAGVLCSCIPLIVI 190
Query: 2549 GQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGG 2728
A M A AG + + IRTV A T + + + S L+ +
Sbjct: 191 AGAAMSLIMSKMAGRGQVAYAEAGNVVEQTVGAIRTVVAFTGEKQATEKYESKLEIAYKT 250
Query: 2729 NISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTI 2908
+ + +I G G ++ F +Y A +G LI +K V+ V+FA+ ++
Sbjct: 251 VVQQGLISGFGLGTMLAVIFCSYGLAVWYGAKLIMEKGY--NGGQVINVIFAVLTGGMSL 308
Query: 2909 GFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKLNKVFFRYPERP 3085
G + + AA +F ++ P+ID SG+ + + G+++L V+FRYP RP
Sbjct: 309 GQTSPSLNAFAAGRAAAFKMFETIKRSPKIDAYDMSGSVLEDIRGDIELKDVYFRYPARP 368
Query: 3086 AVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKH 3265
V I G ++ V G+T+ALVG SG GKSTVISL+ER YDP G V +DN DL+++ K
Sbjct: 369 DVQIFAGFSLFVPNGKTVALVGQSGSGKSTVISLIERFYDPESGQVLIDNIDLKKLQLKW 428
Query: 3266 LRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETR 3445
+R I LVSQEP+LF T+I+ENI YG + + T ++I TA AN KFID+LP G +T
Sbjct: 429 IRSKIGLVSQEPVLFATTIKENIAYGKE--DATDQEIRTAIELANAAKFIDKLPQGLDTM 486
Query: 3446 VGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCI 3625
VGE GTQ+SGGQKQR+AIARA+++NPKILLLDEATSALD ESE+ VQ AL +RT +
Sbjct: 487 VGEHGTQMSGGQKQRLAIARAILKNPKILLLDEATSALDAESERIVQDALVNLMSNRTTV 546
Query: 3626 VVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIA-KRGAYFALTQKQSSNQ 3775
VVAHRL+TI A I VV G++VE+GTH+E+I GAY L + Q ++
Sbjct: 547 VVAHRLTTIRTADVIAVVHQGKIVEKGTHDEMIQDPEGAYSQLVRLQEGSK 597
>gi|15228506|ref|NP_189528.1| multidrug resistance P-glycoprotein,
putative [Arabidopsis thaliana]
gi|9294227|dbj|BAB02129.1| P-glycoprotein; multi-drug resistance
related; ABC transporter-like protein [Arabidopsis
thaliana]
Length = 1252
Score = 762 bits (1967), Expect = 0.0
Identities = 430/1245 (34%), Positives = 670/1245 (53%), Gaps = 3/1245 (0%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+ F+L+ + D L++ VG + + G +P+ ++ G + F G +D +
Sbjct: 24 LPFFKLFSFADKFDYLLMFVGSLGAIVHGSSMPVFFLLFGQMVNGF---GKNQMDLH--- 77
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
+ HEV + L +VYLG + + + + +C+M E+ R+++ +V++
Sbjct: 78 --------QMVHEVSRYSLYFVYLGLVVCFSSYAEIACWMYSGERQVAALRKKYLEAVLK 129
Query: 401 QEIAWYDKNT-SGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
Q++ ++D + +G + + + V++ +KVG ++ F+ G V F W L L
Sbjct: 130 QDVGFFDTDARTGDIVFSVSTDTLLVQDAISEKVGNFIHYLSTFLAGLVVGFVSAWKLAL 189
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
+ +++ P + G YA AG IAE+ + +RTV ++ G+
Sbjct: 190 LSVAVIPGIAFAGGLYAYTLTGITSKSRESYANAGVIAEQAIAQVRTVYSYVGESKALNA 249
Query: 758 YEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFF 937
Y DA+++ K G K G GL + I S+ L FW F+ +G+ + G T F
Sbjct: 250 YSDAIQYTLKLGYKAGMAKGLGLGCTYGIACMSWALVFWYAGVFIRNGQTDGGKAFTAIF 309
Query: 938 SVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNK 1117
S ++G M+LGQ+ A L E+I++ P I +G+ ++ G I
Sbjct: 310 SAIVGGMSLGQSFSNLGAFSKGKAAGYKLMEIINQRPTIIQDPLDGKCLDQVHGNIEFKD 369
Query: 1118 VEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDI 1297
V F+YP+R DV I + ++ G+TVA+VG SG GKST++ L++RFY+P++GQIL+D +
Sbjct: 370 VTFSYPSRPDVMIFRNFNIFFPSGKTVAVVGGSGSGKSTVVSLIERFYDPNSGQILLDGV 429
Query: 1298 PIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTF 1477
I+ +K+LR+ +G+V+QEP LF T+I +NI YG+ D + ++ A ANA FI
Sbjct: 430 EIKTLQLKFLREQIGLVNQEPALFATTILENILYGKPDATMVEVEAAASAANAHSFITLL 489
Query: 1478 PEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENA 1657
P+G +T VG+RGVQ+SGGQKQRIAIARA++++PKILLLDEATSALDA SESIVQ AL+
Sbjct: 490 PKGYDTQVGERGVQLSGGQKQRIAIARAMLKDPKILLLDEATSALDASSESIVQEALDRV 549
Query: 1658 SRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVDD 1837
GRTT+V+AHRL T+RN D I V++ GQV+E GTHE LI + G Y L+ Q D
Sbjct: 550 MVGRTTVVVAHRLCTIRNVDSIAVIQQGQVVETGTHEELIAKSGAYASLIRFQEMVGTRD 609
Query: 1838 KPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXGA 2017
R S + S + + + + A
Sbjct: 610 F-SNPSTRRTRSTRLSHSLSTKSLSLRSGSLRNLSYSYSTGADGRIEMISNAETDRKTRA 668
Query: 2018 VKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGH 2197
+ +++L+ PEW Y ++ G + P F++ S +I VF D D M++
Sbjct: 669 PENYFYRLLKLNSPEWPYSIMGAVGSILSGFIGPTFAIVMSNMIEVFYYTDYDSMERKTK 728
Query: 2198 FWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGR 2377
+ +++ + L Q F + E LT R+R + +LR + +FD +H+
Sbjct: 729 EYVFIYIGAGLYAVGAYLIQHYFFSIMGENLTTRVRRMMLSAILRNEVGWFDEDEHNSSL 788
Query: 2378 ITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQA 2557
I RLATDA ++KSAI R+ I + S+ +AF W+++ L++ FP + +
Sbjct: 789 IAARLATDAADVKSAIAERISVILQNMTSLLTSFIVAFIVEWRVSLLILGTFPLLVLANF 848
Query: 2558 LMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNIS 2737
G A AK A E + NIRTV A Q+K+ ++FC L P ++
Sbjct: 849 AQQLSLKGFAGDTAKAHAKTSMIAGEGVSNIRTVAAFNAQSKILSLFCHELRVPQKRSLY 908
Query: 2738 KAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFA 2917
++ G +G + + + A +G L+ + V++V + + ++
Sbjct: 909 RSQTSGFLFGLSQLALYGSEALILWYGAHLV--SKGVSTFSKVIKVFVVLVITANSVAET 966
Query: 2918 ASYFPEYIKATFAAGLIFNMLEEEPRID-GMTSSGTYPQLSGEVKLNKVFFRYPERPAVP 3094
S PE I+ A G +F++L+ + RID + + G+++ V F YP RP V
Sbjct: 967 VSLAPEIIRGGEAVGSVFSVLDRQTRIDPDDADADPVETIRGDIEFRHVDFAYPSRPDVM 1026
Query: 3095 ILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRK 3274
+ + N+ ++ G + ALVG SG GKS+VI+++ER YDPL G V +D D+R++N K LR
Sbjct: 1027 VFRDFNLRIRAGHSQALVGASGSGKSSVIAMIERFYDPLAGKVMIDGKDIRRLNLKSLRL 1086
Query: 3275 HIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGE 3454
I LV QEP LF +I +NI YG T ++ A AN H FI LP+GY+T VGE
Sbjct: 1087 KIGLVQQEPALFAATIFDNIAYGKDGA--TESEVIDAARAANAHGFISGLPEGYKTPVGE 1144
Query: 3455 KGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVA 3634
+G QLSGGQKQRIAIARA+++NP +LLLDEATSALD ESE +Q AL+ + RT +VVA
Sbjct: 1145 RGVQLSGGQKQRIAIARAVLKNPTVLLLDEATSALDAESECVLQEALERLMRGRTTVVVA 1204
Query: 3635 HRLSTIVNAGCIMVVKNGQVVEQGTHNELIAK-RGAYFALTQKQS 3766
HRLSTI CI V+++G++VEQG+H+EL+++ GAY L Q Q+
Sbjct: 1205 HRLSTIRGVDCIGVIQDGRIVEQGSHSELVSRPEGAYSRLLQLQT 1249
>gi|22655312|gb|AAM98246.1| putative ABC transporter [Arabidopsis
thaliana]
Length = 1286
Score = 759 bits (1960), Expect = 0.0
Identities = 446/1261 (35%), Positives = 680/1261 (53%), Gaps = 20/1261 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
++ +L+R+ +D +++ +G + + G LPL ++ +F + NS
Sbjct: 27 VAFKELFRFADGLDYVLMGIGSVGAFVHGCSLPLFLRFFADLVNSFGS--------NSNN 78
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
EK EV++ L ++ +G I+A+ + + SC+M E+ + + R ++ + +
Sbjct: 79 VEK------MMEEVLKYALYFLVVGAAIWASSWAEISCWMWSGERQTTKMRIKYLEAALN 132
Query: 401 QEIAWYDKNTSGTLSNKLF---DNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLL 571
Q+I ++D T S+ +F + V++ +K+G MA F+ GF V FT W L
Sbjct: 133 QDIQFFD--TEVRTSDVVFAINTDAVMVQDAISEKLGNFIHYMATFVSGFIVGFTAVWQL 190
Query: 572 TLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYEC 751
L+ +++ P + + G + AG I E+ + IR V+AF G+
Sbjct: 191 ALVTLAVVPLIAVIGGIHTTTLSKLSNKSQESLSQAGNIVEQTVVQIRVVMAFVGESRAS 250
Query: 752 KRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTV 931
+ Y AL+ +K G K G GL + + +++ Y L W V G +
Sbjct: 251 QAYSSALKIAQKLGYKTGLAKGMGLGATYFVVFCCYALLLWYDGYLVRHHLTNGGLAIAT 310
Query: 932 FFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISV 1111
F+VM+G +ALGQ+ A A AAA ++ +ID P I+ S G ++G + +
Sbjct: 311 MFAVMIGGLALGQSAPSMAAFAKAKVAAAKIFRIIDHKPTIERNSESGVELDSVTGLVEL 370
Query: 1112 NKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILID 1291
V+F+YP+R DVKIL L G+T+ALVGSSG GKST++ L++RFY+P++GQ+L+D
Sbjct: 371 KNVDFSYPSRPDVKILNNFCLSVPAGKTIALVGSSGSGKSTVVSLIERFYDPNSGQVLLD 430
Query: 1292 DIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIK 1471
++ +++LRQ +G+VSQEP LF TSI++NI GR D +I A + ANA FI
Sbjct: 431 GQDLKTLKLRWLRQQIGLVSQEPALFATSIKENILLGRPDADQVEIEEAARVANAHSFII 490
Query: 1472 TFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALE 1651
P+G +T VG+RG+Q+SGGQKQRIAIARA+++NP ILLLDEATSALD+ESE +VQ AL+
Sbjct: 491 KLPDGFDTQVGERGLQLSGGQKQRIAIARAMLKNPAILLLDEATSALDSESEKLVQEALD 550
Query: 1652 NASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIE--QKGLYHELVHAQVFA 1825
GRTT++IAHRLST+R AD + V++ G V E+GTH+ L + G+Y +L+ Q A
Sbjct: 551 RFMIGRTTLIIAHRLSTIRKADLVAVLQQGSVSEIGTHDELFSKGENGVYAKLIKMQEAA 610
Query: 1826 DV-------DDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXX 1984
+ A +S R S ++
Sbjct: 611 HETAMSNARKSSARPSSARNSVSSPIMTRNSSYGRSPYSRRLSDFSTSDFSLSIDASSYP 670
Query: 1985 XXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSN 2164
+ +++ + PEW Y +I G++ F+ S +++V+ N
Sbjct: 671 NYRNEKLAFKDQANSFWRLAKMNSPEWKYALLGSVGSVICGSLSAFFAYVLSAVLSVYYN 730
Query: 2165 PDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDAT 2344
PD + M K + + + L++ Q S + + E LT R+R K+ VL+ +
Sbjct: 731 PDHEYMIKQIDKYCYLLIGLSSAALVFNTLQHSFWDIVGENLTKRVREKMLSAVLKNEMA 790
Query: 2345 YFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVM 2524
+FD ++ RI RLA DA N++SAI R+ I A + F W++A +++
Sbjct: 791 WFDQEENESARIAARLALDANNVRSAIGDRISVIVQNTALMLVACTAGFVLQWRLALVLV 850
Query: 2525 AIFPFMAVGQAL----MMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYN 2692
A+FP + L M + G + AK + AG EAI N+RTV A + K+
Sbjct: 851 AVFPVVVAATVLQKMFMTGFSGDLEAAHAKGTQLAG----EAIANVRTVAAFNSEAKIVR 906
Query: 2693 IFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLR 2872
++ ++L+ P K I G YG A + +YA + +L+ K+ + + +R
Sbjct: 907 LYTANLEPPLKRCFWKGQIAGSGYGVAQFCLYASYALGLWYASWLV--KHGISDFSKTIR 964
Query: 2873 VLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRI--DGMTSSGTYPQLSGEV 3046
V + S + P++IK A +F +L+ + I D ++ +L GEV
Sbjct: 965 VFMVLMVSANGAAETLTLAPDFIKGGQAMRSVFELLDRKTEIEPDDPDTTPVPDRLRGEV 1024
Query: 3047 KLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVT 3226
+L + F YP RP + I + L++ + G+TLALVGPSGCGKS+VISL++R Y+P G V
Sbjct: 1025 ELKHIDFSYPSRPDIQIFRDLSLRARAGKTLALVGPSGCGKSSVISLIQRFYEPSSGRVM 1084
Query: 3227 VDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIH 3406
+D D+R+ N K +RKHIA+V QEP LF T+I ENI YG + T +I A + A+ H
Sbjct: 1085 IDGKDIRKYNLKAIRKHIAIVPQEPCLFGTTIYENIAYGHECA--TEAEIIQAATLASAH 1142
Query: 3407 KFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQ 3586
KFI LP+GY+T VGE+G QLSGGQKQRIAIARAL+R +I+LLD ATSALD ESE+ VQ
Sbjct: 1143 KFISALPEGYKTYVGERGVQLSGGQKQRIAIARALVRKAEIMLLDGATSALDAESERSVQ 1202
Query: 3587 VALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKR--GAYFALTQK 3760
ALD A RT IVVAHRLSTI NA I V+ +G+V EQG+H+ L+ G Y + Q
Sbjct: 1203 EALDQACSGRTSIVVAHRLSTIRNAHVIAVIDDGKVAEQGSHSHLLKNHPDGIYARMIQL 1262
Query: 3761 Q 3763
Q
Sbjct: 1263 Q 1263
Score = 337 bits (865), Expect = 1e-90
Identities = 197/536 (36%), Positives = 303/536 (55%), Gaps = 13/536 (2%)
Frame = +2
Query: 254 HE-VIQNCLKYVYLGCGIFAAGF----LQASCFMVICEKLSNRFRRQFFHSVMRQEIAWY 418
HE +I+ KY YL G+ +A LQ S + ++ E L+ R R + +V++ E+AW+
Sbjct: 733 HEYMIKQIDKYCYLLIGLSSAALVFNTLQHSFWDIVGENLTKRVREKMLSAVLKNEMAWF 792
Query: 419 DK--NTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSL 592
D+ N S ++ +L + VR GD++ + Q A + F W L L+++++
Sbjct: 793 DQEENESARIAARLALDANNVRSAIGDRISVIVQNTALMLVACTAGFVLQWRLALVLVAV 852
Query: 593 SPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDAL 772
P ++ + +A +A E + ++RTV AFN + + Y L
Sbjct: 853 FPVVVAATVLQKMFMTGFSGDLEAAHAKGTQLAGEAIANVRTVAAFNSEAKIVRLYTANL 912
Query: 773 EHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMG 952
E K K + G+G +YASY L W + V G + + VF +M+
Sbjct: 913 EPPLKRCFWKGQIAGSGYGVAQFCLYASYALGLWYASWLVKHGISDFSKTIRVFMVLMVS 972
Query: 953 SMALGQA---GQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQ-TPSKISGRISVNKV 1120
+ + F G A+ S++E++DR EI+ + P ++ G + + +
Sbjct: 973 ANGAAETLTLAPDFIKGGQAM---RSVFELLDRKTEIEPDDPDTTPVPDRLRGEVELKHI 1029
Query: 1121 EFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIP 1300
+F+YP+R D++I + +SL A+ G+T+ALVG SGCGKS++I L+QRFY P +G+++ID
Sbjct: 1030 DFSYPSRPDIQIFRDLSLRARAGKTLALVGPSGCGKSSVISLIQRFYEPSSGRVMIDGKD 1089
Query: 1301 IEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFP 1480
I +N+K +R+ + +V QEP LF T+I +NI YG ++ +I +A A+A FI P
Sbjct: 1090 IRKYNLKAIRKHIAIVPQEPCLFGTTIYENIAYGHECATEAEIIQAATLASAHKFISALP 1149
Query: 1481 EGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENAS 1660
EG T VG+RGVQ+SGGQKQRIAIARALVR +I+LLD ATSALDAESE VQ AL+ A
Sbjct: 1150 EGYKTYVGERGVQLSGGQKQRIAIARALVRKAEIMLLDGATSALDAESERSVQEALDQAC 1209
Query: 1661 RGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQ--KGLYHELVHAQVF 1822
GRT+IV+AHRLST+RNA I V+ G+V E G+H L++ G+Y ++ Q F
Sbjct: 1210 SGRTSIVVAHRLSTIRNAHVIAVIDDGKVAEQGSHSHLLKNHPDGIYARMIQLQRF 1265
Score = 336 bits (862), Expect = 2e-90
Identities = 207/562 (36%), Positives = 308/562 (53%), Gaps = 5/562 (0%)
Frame = +2
Query: 2099 IQGAVMPAFSLFFSQIINVFSNPDR--DQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFG 2272
+ G +P F FF+ ++N F + ++M ++ +AL FLV+ A S + S +
Sbjct: 53 VHGCSLPLFLRFFADLVNSFGSNSNNVEKMMEEVLKYALYFLVVGAAIWASSWAEISCWM 112
Query: 2273 VAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFN 2452
+ ER T ++R K L QD +FD + + + TDA ++ AI +LG+ +
Sbjct: 113 WSGERQTTKMRIKYLEAALNQDIQFFDTEVRTSD-VVFAINTDAVMVQDAISEKLGNFIH 171
Query: 2453 AIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAM 2632
+A+ G + F WQ+A + +A+ P +AV + + + + AG
Sbjct: 172 YMATFVSGFIVGFTAVWQLALVTLAVVPLIAVIGGIHTTTLSKLSNKSQESLSQAGNIVE 231
Query: 2633 EAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFR 2812
+ + IR V A +++ + S L + +G+ G + F YA
Sbjct: 232 QTVVQIRVVMAFVGESRASQAYSSALKIAQKLGYKTGLAKGMGLGATYFVVFCCYALLLW 291
Query: 2813 FGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEP 2992
+ +L+ ++ L + +FA+ +G +A + KA AA IF +++ +P
Sbjct: 292 YDGYLV--RHHLTNGGLAIATMFAVMIGGLALGQSAPSMAAFAKAKVAAAKIFRIIDHKP 349
Query: 2993 RIDGMTSSGT-YPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGK 3169
I+ + SG ++G V+L V F YP RP V IL + V G+T+ALVG SG GK
Sbjct: 350 TIERNSESGVELDSVTGLVELKNVDFSYPSRPDVKILNNFCLSVPAGKTIALVGSSGSGK 409
Query: 3170 STVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQ 3349
STV+SL+ER YDP G V +D DL+ + + LR+ I LVSQEP LF TSI+ENI+ G
Sbjct: 410 STVVSLIERFYDPNSGQVLLDGQDLKTLKLRWLRQQIGLVSQEPALFATSIKENILLGRP 469
Query: 3350 PGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKI 3529
+ +IE A AN H FI +LPDG++T+VGE+G QLSGGQKQRIAIARA+++NP I
Sbjct: 470 DADQV--EIEEAARVANAHSFIIKLPDGFDTQVGERGLQLSGGQKQRIAIARAMLKNPAI 527
Query: 3530 LLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGT 3709
LLLDEATSALD+ESEK VQ ALD RT +++AHRLSTI A + V++ G V E GT
Sbjct: 528 LLLDEATSALDSESEKLVQEALDRFMIGRTTLIIAHRLSTIRKADLVAVLQQGSVSEIGT 587
Query: 3710 HNELIAK--RGAYFALTQKQSS 3769
H+EL +K G Y L + Q +
Sbjct: 588 HDELFSKGENGVYAKLIKMQEA 609
>gi|26449438|dbj|BAC41846.1| putative P-glycoprotein [Arabidopsis
thaliana]
Length = 1252
Score = 759 bits (1959), Expect = 0.0
Identities = 429/1245 (34%), Positives = 669/1245 (53%), Gaps = 3/1245 (0%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+ F+L+ + D L++ VG + + G +P+ ++ G + F G +D +
Sbjct: 24 LPFFKLFSFADKFDYLLMFVGSLGAIVHGSSMPVFFLLFGQMVNGF---GKNQMDLH--- 77
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
+ HEV + L +VYLG + + + + +C+M E+ R+++ +V++
Sbjct: 78 --------QMVHEVSRYSLYFVYLGLVVCFSSYAEIACWMYSGERQVAALRKKYLEAVLK 129
Query: 401 QEIAWYDKNT-SGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
Q++ ++D + +G + + + V++ +KVG ++ F+ G V F W L L
Sbjct: 130 QDVGFFDTDARTGDIVFSVSTDTLLVQDAISEKVGNFIHYLSTFLAGLVVGFVSAWKLAL 189
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
+ +++ P + G YA AG IAE+ + +RTV ++ G+
Sbjct: 190 LSVAVIPGIAFAGGLYAYTLTGITSKSRESYANAGVIAEQAIAQVRTVYSYVGESKALNA 249
Query: 758 YEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFF 937
Y DA+++ K G K G GL + I S+ L FW F+ +G+ + G T F
Sbjct: 250 YSDAIQYTLKLGYKAGMAKGLGLGCTYGIACMSWALVFWYAGVFIRNGQTDGGKAFTAIF 309
Query: 938 SVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNK 1117
S ++G M+LGQ+ A L E+I++ P I +G+ ++ G I
Sbjct: 310 SAIVGGMSLGQSFSNLGAFSKGKAAGYKLMEIINQRPTIIQDPLDGKCLDQVHGNIEFKD 369
Query: 1118 VEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDI 1297
V F+YP+R DV I + ++ G+TVA+VG SG GKST++ L++RFY+P++GQIL+D +
Sbjct: 370 VTFSYPSRPDVMIFRNFNIFFPSGKTVAVVGGSGSGKSTVVSLIERFYDPNSGQILLDGV 429
Query: 1298 PIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTF 1477
I+ +K+LR+ +G+V+QEP LF T+I +NI YG+ D + ++ A ANA FI
Sbjct: 430 EIKTLQLKFLREQIGLVNQEPALFATTILENILYGKPDATMVEVEAAASAANAHSFITLL 489
Query: 1478 PEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENA 1657
P+G +T VG+RGVQ+SGGQKQRIAIARA++++PKILLLDEATSALDA SESIVQ AL+
Sbjct: 490 PKGYDTQVGERGVQLSGGQKQRIAIARAMLKDPKILLLDEATSALDASSESIVQEALDRV 549
Query: 1658 SRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVDD 1837
GRTT+V+AHRL T+RN D I V++ GQV+E GTHE LI + G Y L+ Q D
Sbjct: 550 MVGRTTVVVAHRLCTIRNVDSIAVIQQGQVVETGTHEELIAKSGAYASLIRFQEMVGTRD 609
Query: 1838 KPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXGA 2017
R S + S + + + + A
Sbjct: 610 F-SNPSTRRTRSTRLSHSLSTKSLSLRSGSLRNLSYSYSTGADGRIEMISNAETDRKTRA 668
Query: 2018 VKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGH 2197
+ +++L+ PEW Y ++ G + P F++ S +I VF D D M++
Sbjct: 669 PENYFYRLLKLNSPEWPYSIMGAVGSILSGFIGPTFAIVMSNMIEVFYYTDYDSMERKTK 728
Query: 2198 FWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGR 2377
+ +++ + L Q F + E LT R+R + +LR + +FD +H+
Sbjct: 729 EYVFIYIGAGLYAVGAYLIQHYFFSIMGENLTTRVRRMMLSAILRNEVGWFDEDEHNSSL 788
Query: 2378 ITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQA 2557
I RLATDA ++KSAI R+ I + S+ +AF W+++ L++ FP + +
Sbjct: 789 IAARLATDAADVKSAIAERISVILQNMTSLLTSFIVAFIVEWRVSLLILGTFPLLVLANF 848
Query: 2558 LMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNIS 2737
G A AK A E + NIRTV A Q+K+ ++FC L P ++
Sbjct: 849 AQQLSLKGFAGDTAKAHAKTSMIAGEGVSNIRTVAAFNAQSKILSLFCHELRVPQKRSLY 908
Query: 2738 KAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFA 2917
++ G +G + + + A +G L+ + V++V + + ++
Sbjct: 909 RSQTSGFLFGLSQLALYGSEALILWYGAHLV--SKGVSTFSKVIKVFVVLVITANSVAET 966
Query: 2918 ASYFPEYIKATFAAGLIFNMLEEEPRID-GMTSSGTYPQLSGEVKLNKVFFRYPERPAVP 3094
S PE I+ A G +F++L+ + RID + + G+++ V F YP RP V
Sbjct: 967 VSLAPEIIRGGEAVGSVFSVLDRQTRIDPDDADADPVETIRGDIEFRHVDFAYPSRPDVM 1026
Query: 3095 ILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRK 3274
+ + N+ ++ G + ALVG SG GKS+VI+++ER YDPL G V +D D+R++N K LR
Sbjct: 1027 VFRDFNLRIRAGHSQALVGASGSGKSSVIAMIERFYDPLAGKVMIDGKDIRRLNLKSLRL 1086
Query: 3275 HIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGE 3454
I LV QEP LF +I +NI YG T ++ A AN H FI LP+GY+T VGE
Sbjct: 1087 KIGLVQQEPALFAATIFDNIAYGKDGA--TESEVIDAARAANAHGFISGLPEGYKTPVGE 1144
Query: 3455 KGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVA 3634
+G QLSGGQKQRIAIARA+++NP +LLLDEATSALD ESE +Q AL+ + RT +VVA
Sbjct: 1145 RGVQLSGGQKQRIAIARAVLKNPTVLLLDEATSALDAESECVLQEALERLMRGRTTVVVA 1204
Query: 3635 HRLSTIVNAGCIMVVKNGQVVEQGTHNELIAK-RGAYFALTQKQS 3766
HRLSTI CI V+++ ++VEQG+H+EL+++ GAY L Q Q+
Sbjct: 1205 HRLSTIRGVDCIGVIQDERIVEQGSHSELVSRPEGAYSRLLQLQT 1249
>gi|24324262|gb|AAN28720.2| MDR-like p-glycoprotein [Arabidopsis
thaliana]
Length = 1252
Score = 758 bits (1957), Expect = 0.0
Identities = 429/1245 (34%), Positives = 669/1245 (53%), Gaps = 3/1245 (0%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+ F+L+ + D L++ VG + + G +P+ ++ G + F G +D +
Sbjct: 24 LPFFKLFSFADKFDYLLMFVGSLGAIVHGSSMPVFFLLFGQMVNGF---GKNQMDLH--- 77
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
+ HEV + L +VYLG + + + + +C+M E+ R+++ +V++
Sbjct: 78 --------QMVHEVSRYSLYFVYLGLVVCFSSYAEIACWMYSGERQVAALRKKYLEAVLK 129
Query: 401 QEIAWYDKNT-SGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
Q++ ++D + +G + + + V++ +KVG ++ F+ G V F W L L
Sbjct: 130 QDVGFFDTDARTGDIVFSVSTDTLLVQDAISEKVGNFIHYLSTFLAGLVVGFVSAWKLAL 189
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
+ +++ P + G YA AG IAE+ + +RTV ++ G+
Sbjct: 190 LSVAVIPGIAFAGGLYAYTLTGITSKSRESYANAGVIAEQAIAQVRTVYSYVGESKALNA 249
Query: 758 YEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFF 937
Y DA+++ K G K G GL + I S+ L FW F+ +G+ + G T F
Sbjct: 250 YSDAIQYTLKLGYKAGMAKGLGLGCTYGIACMSWALVFWYAGVFIRNGQTDGGKAFTAIF 309
Query: 938 SVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNK 1117
S ++G M+LGQ+ A L E+I++ P I +G+ ++ G I
Sbjct: 310 SAIVGGMSLGQSFSNLGAFSKGKAAGYKLMEIINQRPTIIQDPLDGKCLDQVHGNIEFKD 369
Query: 1118 VEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDI 1297
V F+YP+R DV I + ++ G+TVA+VG SG GKST++ L++RFY+P++GQIL+D +
Sbjct: 370 VTFSYPSRPDVMIFRNFNIFFPSGKTVAVVGGSGSGKSTVVSLIERFYDPNSGQILLDGV 429
Query: 1298 PIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTF 1477
I+ +K+LR+ +G+V+QEP LF T+I +NI YG+ D + ++ A ANA FI
Sbjct: 430 EIKTLQLKFLREQIGLVNQEPALFATTILENILYGKPDATMVEVEAAASAANAHSFITLL 489
Query: 1478 PEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENA 1657
P+G +T VG+RGVQ+SGGQKQRIAIARA++++PKILLLDEATSALDA SESIVQ AL+
Sbjct: 490 PKGYDTQVGERGVQLSGGQKQRIAIARAMLKDPKILLLDEATSALDASSESIVQEALDRV 549
Query: 1658 SRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVDD 1837
GRTT+V+AHRL T+RN D I V++ GQV+E GTHE LI + G Y L+ Q D
Sbjct: 550 MVGRTTVVVAHRLCTIRNVDSIAVIQQGQVVETGTHEELIAKSGAYASLIRFQEMVGTRD 609
Query: 1838 KPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXGA 2017
R S + S + + + + A
Sbjct: 610 F-SNPSTRRTRSTRLSHSLSTKSLSLRSGSLRNLSYSYSTGADGRIEMISNAETDRKTRA 668
Query: 2018 VKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGH 2197
+ +++L+ PEW Y ++ G + P F++ S +I VF D D M++
Sbjct: 669 PENYFYRLLKLNSPEWPYSIMGAVGSILSGFIGPTFAIVMSNMIEVFYYTDYDSMERKTK 728
Query: 2198 FWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGR 2377
+ +++ + L Q F + E LT R+R + +LR + +FD +H+
Sbjct: 729 EYVFIYIGAGLYAVGAYLIQHYFFSIMGENLTTRVRRMMLSAILRNEVGWFDEDEHNSSL 788
Query: 2378 ITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQA 2557
I RLATDA ++KSAI R+ I + S+ +AF W+++ L++ FP + +
Sbjct: 789 IAARLATDAADVKSAIAERISVILQNMTSLLTSFIVAFIVEWRVSLLILGTFPLLVLANF 848
Query: 2558 LMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNIS 2737
G A AK A E + NIRTV A Q+K+ ++FC L P ++
Sbjct: 849 AQQLSLKGFAGDTAKAHAKTSMIAGEGVSNIRTVAAFNAQSKILSLFCHELRVPQKRSLY 908
Query: 2738 KAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFA 2917
++ G +G + + + A +G L+ + V++V + + ++
Sbjct: 909 RSQTSGFLFGLSQLALYGSEALILWYGAHLV--SKGVSTFSKVIKVFVVLVITANSVAET 966
Query: 2918 ASYFPEYIKATFAAGLIFNMLEEEPRID-GMTSSGTYPQLSGEVKLNKVFFRYPERPAVP 3094
S PE I+ A G +F++L+ + RID + + G+++ V F YP RP V
Sbjct: 967 VSLAPEIIRGGEAVGSVFSVLDRQTRIDPDDADADPVETIRGDIEFRHVDFAYPSRPDVM 1026
Query: 3095 ILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRK 3274
+ + N+ ++ G + ALVG SG GKS+VI+++ER YD L G V +D D+R++N K LR
Sbjct: 1027 VFRDFNLRIRAGHSQALVGASGSGKSSVIAMIERFYDLLAGKVMIDGKDIRRLNLKSLRL 1086
Query: 3275 HIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGE 3454
I LV QEP LF +I +NI YG T ++ A AN H FI LP+GY+T VGE
Sbjct: 1087 KIGLVQQEPALFAATIFDNIAYGKDGA--TESEVIDAARAANAHGFISGLPEGYKTPVGE 1144
Query: 3455 KGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVA 3634
+G QLSGGQKQRIAIARA+++NP +LLLDEATSALD ESE +Q AL+ + RT +VVA
Sbjct: 1145 RGVQLSGGQKQRIAIARAVLKNPTVLLLDEATSALDAESECVLQEALERLMRGRTTVVVA 1204
Query: 3635 HRLSTIVNAGCIMVVKNGQVVEQGTHNELIAK-RGAYFALTQKQS 3766
HRLSTI CI V+++G++VEQG+H+EL+++ GAY L Q Q+
Sbjct: 1205 HRLSTIRGVDCIGVIQDGRIVEQGSHSELVSRPEGAYSRLLQLQT 1249
>gi|4204793|gb|AAD10836.1| P-glycoprotein [Solanum tuberosum]
Length = 1313
Score = 757 bits (1955), Expect = 0.0
Identities = 450/1254 (35%), Positives = 677/1254 (53%), Gaps = 17/1254 (1%)
Frame = +2
Query: 53 QLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKA 232
+L+R+ +D +++ +G + + G LPL ++ +F G+ D +
Sbjct: 57 ELFRFADGLDCVLMIIGSLGAFVHGCSLPLFLRFFADLVNSF---GSYANDVD------- 106
Query: 233 AARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIA 412
+ + EV++ ++ +G I+A+ + + SC+M E+ + + R ++ + + Q+I
Sbjct: 107 ----KMTQEVLKYAFYFLVVGAAIWASSWAEISCWMWTGERQTTKMRIKYLEAALNQDIQ 162
Query: 413 WYDKN--TSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMM 586
++D TS +S D + V++ +K+G MA F+ GF V FT W L L+ +
Sbjct: 163 YFDTEVRTSDVVSAINTDAVV-VQDAISEKLGNFIHYMATFLSGFVVGFTAVWQLALVTL 221
Query: 587 SLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYED 766
++ P + + G + AG I E+ + IRTV+ F G+ + Y
Sbjct: 222 AVVPLIAVIGAIYTVTSAKLSSQSQEALSKAGNIVEQTVVQIRTVLVFVGEAKALQAYTA 281
Query: 767 ALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVM 946
AL +K G K F G GL + + ++ Y L W G V G + F+VM
Sbjct: 282 ALRVSQKIGYKSGFSKGLGLGATYFTVFCCYALLLWYGGYLVRHHFTNGGLAIATMFAVM 341
Query: 947 MGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEF 1126
+G +ALGQ+ A AAA ++ +ID P +D + G +SG++ + VEF
Sbjct: 342 IGGLALGQSAPSMTAFAKARVAAAKIFRIIDHKPSVDRNAKTGLELDTVSGQLELKNVEF 401
Query: 1127 TYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIE 1306
+YP+R ++KIL +L G+T+ALVGSSG GKST++ L++RFY+P +GQ+++D I+
Sbjct: 402 SYPSRPEIKILNNFNLVVPAGKTIALVGSSGSGKSTVVSLIERFYDPTSGQLMLDGNDIK 461
Query: 1307 DFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEG 1486
+K+LRQ +G+VSQEP LF TSI++NI GR D + +I A + ANA F+ P+G
Sbjct: 462 TLKLKWLRQQIGLVSQEPALFATSIKENILLGRPDATQIEIEEAARVANAHSFVIKLPDG 521
Query: 1487 LNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRG 1666
+T VG+RG+Q+SGGQKQRIAIARA+++NP ILLLDEATSALD+ESE +VQ AL+ G
Sbjct: 522 FDTQVGERGLQLSGGQKQRIAIARAMLKNPAILLLDEATSALDSESEKLVQEALDRFMIG 581
Query: 1667 RTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIE--QKGLYHELVHAQVFADVDDK 1840
RTT+VIAHRLST+R AD + V++ G V E+G+H+ L+ + G+Y +L+ Q A
Sbjct: 582 RTTLVIAHRLSTIRKADLVAVLQQGSVSEIGSHDELMSKGENGMYAKLIKMQEAAHETAL 641
Query: 1841 PKKKEAERRMSRQTSQRKGSV---NFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXX 2011
+++ R S + + N S
Sbjct: 642 SNARKSSARPSSARNSVSSPIITRNSSYGRSPYSRRLSDFSTSDFSLSLDAAYSNYRNEK 701
Query: 2012 GAVKANLFKILRYAR---PEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQM 2182
A K R A+ PEW Y +I G++ F+ S +++V+ NPD M
Sbjct: 702 LAFKDQASSFGRLAKMNSPEWTYALIGSIGSVICGSLSAFFAYVLSAVLSVYYNPDHAYM 761
Query: 2183 KKDGHFWALMFLVLAAVQGTSMLF---QCSLFGVAAERLTMRIRSKVYRNVLRQDATYFD 2353
+ A +L V +++F Q + V E LT R+R K+ VL+ + +FD
Sbjct: 762 SEQ---IAKYCYLLIGVSSAALIFNTLQHYYWDVVGENLTKRVREKMLAAVLKMEMAWFD 818
Query: 2354 MPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIF 2533
++ RI RL+ DA N++SAI R+ I A + F W++A +++ +F
Sbjct: 819 QEENDSSRIAARLSLDANNVRSAIGDRISVIMQNSALMLVACTAGFVLQWRLALVLIGVF 878
Query: 2534 PFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLD 2713
P + L + G + A + A EA+ N+RTV A +TK+ N+F S L
Sbjct: 879 PVVVAATVLQKMFMKGFSGDLEAAHAKATQLAGEAVANVRTVAAFNSETKIVNLFDSSLQ 938
Query: 2714 APHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISF 2893
P K I G YG A + + +YA + +L+ K+ + + +RV +
Sbjct: 939 TPLRRCFWKGQIAGSGYGIAQFLLYSSYALGLWYASWLV--KHGISDFSKTIRVFMVLMV 996
Query: 2894 SFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRI--DGMTSSGTYPQLSGEVKLNKVFF 3067
S + P++IK A +F +L+ + + D ++ +L GEV+ V F
Sbjct: 997 SANGAAETLTLAPDFIKGGRAMRSVFELLDRKTEVEPDDPDATAVPDRLRGEVEFKHVDF 1056
Query: 3068 RYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLR 3247
YP RP V I + LN+ + G+TLALVGPSGCGKS+VISL+ER Y+P G V +D D+R
Sbjct: 1057 SYPTRPDVSIFRDLNLRARAGKTLALVGPSGCGKSSVISLIERFYEPSSGRVIIDGKDIR 1116
Query: 3248 QMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELP 3427
+ N K LR+HIA+V QEP LF T+I ENI YG + T +I A + AN HKFI LP
Sbjct: 1117 KYNLKSLRRHIAVVPQEPCLFATTIYENIAYGHESA--TEAEITEAATLANAHKFISALP 1174
Query: 3428 DGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAA 3607
DGY+T VGE+G QLSGGQKQRIAIARA +R +++LLDEATSALD ESE+ VQ ALD A
Sbjct: 1175 DGYKTFVGERGVQLSGGQKQRIAIARAFLRKAELMLLDEATSALDAESERCVQEALDRAC 1234
Query: 3608 KDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIA--KRGAYFALTQKQ 3763
+T IVVAHRLSTI NA I V+ +G+V EQG+H+ L+ G Y + Q Q
Sbjct: 1235 AGKTTIVVAHRLSTIRNAHVIAVIDDGKVAEQGSHSHLLKNYSDGIYARMIQLQ 1288
Score = 346 bits (887), Expect = 3e-93
Identities = 210/562 (37%), Positives = 311/562 (54%), Gaps = 5/562 (0%)
Frame = +2
Query: 2099 IQGAVMPAFSLFFSQIINVFSN--PDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFG 2272
+ G +P F FF+ ++N F + D D+M ++ +A FLV+ A S + S +
Sbjct: 79 VHGCSLPLFLRFFADLVNSFGSYANDVDKMTQEVLKYAFYFLVVGAAIWASSWAEISCWM 138
Query: 2273 VAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFN 2452
ER T ++R K L QD YFD + + + + TDA ++ AI +LG+ +
Sbjct: 139 WTGERQTTKMRIKYLEAALNQDIQYFDTEVRTSD-VVSAINTDAVVVQDAISEKLGNFIH 197
Query: 2453 AIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAM 2632
+A+ G + F WQ+A + +A+ P +AV A+ ++ + + AG
Sbjct: 198 YMATFLSGFVVGFTAVWQLALVTLAVVPLIAVIGAIYTVTSAKLSSQSQEALSKAGNIVE 257
Query: 2633 EAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFR 2812
+ + IRTV + K + + L +GL G F YA
Sbjct: 258 QTVVQIRTVLVFVGEAKALQAYTAALRVSQKIGYKSGFSKGLGLGATYFTVFCCYALLLW 317
Query: 2813 FGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEP 2992
+G +L+ ++ + +FA+ +G +A + KA AA IF +++ +P
Sbjct: 318 YGGYLV--RHHFTNGGLAIATMFAVMIGGLALGQSAPSMTAFAKARVAAAKIFRIIDHKP 375
Query: 2993 RIDGMTSSGT-YPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGK 3169
+D +G +SG+++L V F YP RP + IL N+ V G+T+ALVG SG GK
Sbjct: 376 SVDRNAKTGLELDTVSGQLELKNVEFSYPSRPEIKILNNFNLVVPAGKTIALVGSSGSGK 435
Query: 3170 STVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQ 3349
STV+SL+ER YDP G + +D ND++ + K LR+ I LVSQEP LF TSI+ENI+ G
Sbjct: 436 STVVSLIERFYDPTSGQLMLDGNDIKTLKLKWLRQQIGLVSQEPALFATSIKENILLGRP 495
Query: 3350 PGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKI 3529
+ T +IE A AN H F+ +LPDG++T+VGE+G QLSGGQKQRIAIARA+++NP I
Sbjct: 496 --DATQIEIEEAARVANAHSFVIKLPDGFDTQVGERGLQLSGGQKQRIAIARAMLKNPAI 553
Query: 3530 LLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGT 3709
LLLDEATSALD+ESEK VQ ALD RT +V+AHRLSTI A + V++ G V E G+
Sbjct: 554 LLLDEATSALDSESEKLVQEALDRFMIGRTTLVIAHRLSTIRKADLVAVLQQGSVSEIGS 613
Query: 3710 HNELIAK--RGAYFALTQKQSS 3769
H+EL++K G Y L + Q +
Sbjct: 614 HDELMSKGENGMYAKLIKMQEA 635
Score = 336 bits (861), Expect = 3e-90
Identities = 191/527 (36%), Positives = 296/527 (55%), Gaps = 12/527 (2%)
Frame = +2
Query: 278 KYVYLGCGIFAAGF----LQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYDK--NTSGT 439
KY YL G+ +A LQ + V+ E L+ R R + +V++ E+AW+D+ N S
Sbjct: 767 KYCYLLIGVSSAALIFNTLQHYYWDVVGENLTKRVREKMLAAVLKMEMAWFDQEENDSSR 826
Query: 440 LSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGL 619
++ +L + VR GD++ + Q A + F W L L+++ + P ++ +
Sbjct: 827 IAARLSLDANNVRSAIGDRISVIMQNSALMLVACTAGFVLQWRLALVLIGVFPVVVAATV 886
Query: 620 FXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIK 799
+A A +A E + ++RTV AFN + ++ +L+ +
Sbjct: 887 LQKMFMKGFSGDLEAAHAKATQLAGEAVANVRTVAAFNSETKIVNLFDSSLQTPLRRCFW 946
Query: 800 KSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQA-- 973
K + G+G ++Y+SY L W + V G + + VF +M+ + +
Sbjct: 947 KGQIAGSGYGIAQFLLYSSYALGLWYASWLVKHGISDFSKTIRVFMVLMVSANGAAETLT 1006
Query: 974 -GQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQT-PSKISGRISVNKVEFTYPTRAD 1147
F G A+ S++E++DR E++ + P ++ G + V+F+YPTR D
Sbjct: 1007 LAPDFIKGGRAM---RSVFELLDRKTEVEPDDPDATAVPDRLRGEVEFKHVDFSYPTRPD 1063
Query: 1148 VKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYL 1327
V I + ++L A+ G+T+ALVG SGCGKS++I L++RFY P +G+++ID I +N+K L
Sbjct: 1064 VSIFRDLNLRARAGKTLALVGPSGCGKSSVISLIERFYEPSSGRVIIDGKDIRKYNLKSL 1123
Query: 1328 RQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEGLNTLVGD 1507
R+ + VV QEP LF T+I +NI YG ++ +I A ANA FI P+G T VG+
Sbjct: 1124 RRHIAVVPQEPCLFATTIYENIAYGHESATEAEITEAATLANAHKFISALPDGYKTFVGE 1183
Query: 1508 RGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIA 1687
RGVQ+SGGQKQRIAIARA +R +++LLDEATSALDAESE VQ AL+ A G+TTIV+A
Sbjct: 1184 RGVQLSGGQKQRIAIARAFLRKAELMLLDEATSALDAESERCVQEALDRACAGKTTIVVA 1243
Query: 1688 HRLSTVRNADKIIVMKAGQVMEVGTHETLIE--QKGLYHELVHAQVF 1822
HRLST+RNA I V+ G+V E G+H L++ G+Y ++ Q F
Sbjct: 1244 HRLSTIRNAHVIAVIDDGKVAEQGSHSHLLKNYSDGIYARMIQLQRF 1290
>gi|15217776|ref|NP_174115.1| multidrug resistance P-glycoprotein,
putative [Arabidopsis thaliana]
gi|25297458|pir||G86404 probable P-glycoprotein [imported] -
Arabidopsis thaliana
gi|12322992|gb|AAG51482.1| P-glycoprotein, putative [Arabidopsis
thaliana]
Length = 1245
Score = 756 bits (1951), Expect = 0.0
Identities = 454/1252 (36%), Positives = 682/1252 (54%), Gaps = 11/1252 (0%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+S+ L+ +D ++ +G + +C G LPL + G + + LG + DP + +
Sbjct: 30 VSLMGLFSAADKLDYFLMLLGGLGACIHGATLPLFFVFFGKMLDS---LGNLSTDPKAIS 86
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
S V QN L VYLG F + ++ SC+M E+ + R R + S++
Sbjct: 87 SR-----------VSQNALYLVYLGLVNFVSAWIGVSCWMQTGERQTARLRINYLKSILA 135
Query: 401 QEIAWYDKNTSGTLSNKLF---DNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLL 571
++I ++D T SN +F + V++ GDK + ++QFI GF + F W L
Sbjct: 136 KDITFFD--TEARDSNLIFHISSDAILVQDAIGDKTDHVLRYLSQFIAGFVIGFLSVWQL 193
Query: 572 TLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYEC 751
TL+ + + P + I G YA AG +AEEV++ +RTV AF G+E
Sbjct: 194 TLLTLGVVPLIAIAGGGYAIVMSTISEKSETAYADAGKVAEEVMSQVRTVYAFVGEEKAV 253
Query: 752 KRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTV 931
K Y ++L+ K G + G G+ + +++ ++ L W + V G+ T
Sbjct: 254 KSYSNSLKKALKLGKRSGLAKGLGVGLTYSLLFCAWALLLWYASLLVRHGKTNGAKAFTT 313
Query: 932 FFSVMMGSMALGQAGQQFATIGTALGAAASLYEVI-DRIPEIDAYSTEGQTPSKISGRIS 1108
+V+ ALGQA + I AAA+++ +I + E EG T ++GRI
Sbjct: 314 ILNVIFSGFALGQAAPSLSAIAKGRVAAANIFRMIGNNNSESSQRLDEGTTLQNVAGRIE 373
Query: 1109 VNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILI 1288
KV F YP+R ++ + + +S + G+T A VG SG GKSTII ++QRFY P++G+IL+
Sbjct: 374 FQKVSFAYPSRPNM-VFENLSFTIRSGKTFAFVGPSGSGKSTIISMVQRFYEPNSGEILL 432
Query: 1289 DDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFI 1468
D I+ +K+ R+ +G+VSQEP LF T+I NI G+ + + + I A K ANA FI
Sbjct: 433 DGNDIKSLKLKWFREQLGLVSQEPALFATTIASNILLGKENANMDQIIEAAKAANADSFI 492
Query: 1469 KTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSAL 1648
K+ P G NT VG+ G Q+SGGQKQRIAIARA++RNPKILLLDEATSALDAESE IVQ AL
Sbjct: 493 KSLPNGYNTQVGEGGTQLSGGQKQRIAIARAVLRNPKILLLDEATSALDAESEKIVQQAL 552
Query: 1649 ENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQ-VFA 1825
+N RTTIV+AHRLST+RN DKI+V++ GQV E G+H L+ + G Y LV+ Q
Sbjct: 553 DNVMEKRTTIVVAHRLSTIRNVDKIVVLRDGQVRETGSHSELMLRGGDYATLVNCQETEP 612
Query: 1826 DVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXX 2005
+ + E + + +S R+ S + +T +VD
Sbjct: 613 QENSRSIMSETCKSQAGSSSSRRVSSSRRTSSFRVDQEKTKNDDSKKDFSS--------- 663
Query: 2006 XXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMK 2185
+ ++++++ PEW Y ++ GA P FS+ + ++ F +P + +K
Sbjct: 664 -----SSMIWELIKLNSPEWPYALLGSIGAVLAGAQTPLFSMGIAYVLTAFYSPFPNVIK 718
Query: 2186 KDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKH 2365
+D A++F V L Q + + ERLT R+R ++ +L + +FD+ ++
Sbjct: 719 RDVEKVAIIFAGAGIVTAPIYLLQHYFYTLMGERLTSRVRLSLFSAILSNEIGWFDLDEN 778
Query: 2366 SPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFM- 2542
+ G +T+ LA DA ++SA+ RL +I ++ L +AF+Y W++A +V A FP +
Sbjct: 779 NTGSLTSILAADATLVRSALADRLSTIVQNLSLTVTALALAFFYSWRVAAVVTACFPLLI 838
Query: 2543 --AVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDA 2716
++ + L +K GG T + A A EAI NIRTV A + ++ F L
Sbjct: 839 AASLTEQLFLKGFGGDYT---RAYSRATSVAREAIANIRTVAAYGAEKQISEQFTCELSK 895
Query: 2717 PHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNV-LMEPENVLRVLFAISF 2893
P + I G YG + + F +YA + LI K + VL +F
Sbjct: 896 PTKNAFVRGHISGFGYGLSQFLAFCSYALGLWYVSVLINHKETNFGDSIKSFMVLIVTAF 955
Query: 2894 SFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRID-GMTSSGTYPQLSGEVKLNKVFFR 3070
S + + P+ +K T A G +F +L E +I +S Q+ G+++ V F
Sbjct: 956 S---VSETLALTPDIVKGTQALGSVFRVLHRETKISPDQPNSRMVSQVKGDIEFRNVSFV 1012
Query: 3071 YPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQ 3250
YP RP + I + LN+ V G++LA+VGPSG GKSTVI L+ R YDP G + +D D++
Sbjct: 1013 YPTRPEIDIFKNLNLRVSAGKSLAVVGPSGSGKSTVIGLIMRFYDPSNGNLCIDGQDIKT 1072
Query: 3251 MNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPD 3430
+N + LRK +ALV QEP LF T+I ENI YG + + +I A AN H+FI ++ +
Sbjct: 1073 LNLRSLRKKLALVQQEPALFSTTIYENIKYGNE--NASEAEIMEAAKAANAHEFIIKMEE 1130
Query: 3431 GYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAK 3610
GY+T G+KG QLSGGQKQR+AIARA++++P +LLLDEATSALDT SEK VQ ALD K
Sbjct: 1131 GYKTHAGDKGVQLSGGQKQRVAIARAVLKDPSVLLLDEATSALDTSSEKLVQEALDKLMK 1190
Query: 3611 DRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIA-KRGAYFALTQKQ 3763
RT ++VAHRLSTI A + V+ G+VVE+G+H EL++ G Y LT Q
Sbjct: 1191 GRTTVLVAHRLSTIRKADTVAVLHKGRVVEKGSHRELVSIPNGFYKQLTSLQ 1242
Score = 316 bits (809), Expect = 3e-84
Identities = 207/569 (36%), Positives = 298/569 (51%), Gaps = 12/569 (2%)
Frame = +2
Query: 2099 IQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHFW--ALMFLVLAAVQGTSMLFQCSLFG 2272
I GA +P F +FF ++++ N D AL + L V S S +
Sbjct: 56 IHGATLPLFFVFFGKMLDSLGNLSTDPKAISSRVSQNALYLVYLGLVNFVSAWIGVSCWM 115
Query: 2273 VAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFN 2452
ER T R+R +++L +D T+FD I +++DA ++ AI + +
Sbjct: 116 QTGERQTARLRINYLKSILAKDITFFDTEARDSNLIF-HISSDAILVQDAIGDKTDHVLR 174
Query: 2453 AIASVGGGLGIAFYYGWQMAFLVMAIFPFMAV---GQALMMKYHGGSATSDAKEME--NA 2617
++ G I F WQ+ L + + P +A+ G A++M S S+ E +A
Sbjct: 175 YLSQFIAGFVIGFLSVWQLTLLTLGVVPLIAIAGGGYAIVM-----STISEKSETAYADA 229
Query: 2618 GKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTY 2797
GK A E + +RTV A + K + + L + +GL G S+ F +
Sbjct: 230 GKVAEEVMSQVRTVYAFVGEEKAVKSYSNSLKKALKLGKRSGLAKGLGVGLTYSLLFCAW 289
Query: 2798 AAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNM 2977
A + L+ ++ + + FS +G AA K AA IF M
Sbjct: 290 ALLLWYASLLV--RHGKTNGAKAFTTILNVIFSGFALGQAAPSLSAIAKGRVAAANIFRM 347
Query: 2978 L-----EEEPRIDGMTSSGTYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLA 3142
+ E R+D T T ++G ++ KV F YP RP + + + L+ ++ G+T A
Sbjct: 348 IGNNNSESSQRLDEGT---TLQNVAGRIEFQKVSFAYPSRPNM-VFENLSFTIRSGKTFA 403
Query: 3143 LVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSI 3322
VGPSG GKST+IS+++R Y+P G + +D ND++ + K R+ + LVSQEP LF T+I
Sbjct: 404 FVGPSGSGKSTIISMVQRFYEPNSGEILLDGNDIKSLKLKWFREQLGLVSQEPALFATTI 463
Query: 3323 RENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIA 3502
NI+ G + +QI A AN FI LP+GY T+VGE GTQLSGGQKQRIAIA
Sbjct: 464 ASNILLGKENANM--DQIIEAAKAANADSFIKSLPNGYNTQVGEGGTQLSGGQKQRIAIA 521
Query: 3503 RALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVK 3682
RA++RNPKILLLDEATSALD ESEK VQ ALD + RT IVVAHRLSTI N I+V++
Sbjct: 522 RAVLRNPKILLLDEATSALDAESEKIVQQALDNVMEKRTTIVVAHRLSTIRNVDKIVVLR 581
Query: 3683 NGQVVEQGTHNELIAKRGAYFALTQKQSS 3769
+GQV E G+H+EL+ + G Y L Q +
Sbjct: 582 DGQVRETGSHSELMLRGGDYATLVNCQET 610
>gi|27368851|emb|CAD59583.1| MDR-like ABC transporter [Oryza sativa
(japonica cultivar-group)]
gi|41052997|dbj|BAD07906.1| MDR-like ABC transporter [Oryza sativa
(japonica cultivar-group)]
gi|41053280|dbj|BAD07706.1| MDR-like ABC transporter [Oryza sativa
(japonica cultivar-group)]
Length = 1264
Score = 755 bits (1950), Expect = 0.0
Identities = 450/1263 (35%), Positives = 697/1263 (54%), Gaps = 18/1263 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+ +L+ + D +++AVG + +CA G +P+ I G + +G +L P +
Sbjct: 35 VPFLKLFSFADRWDYVLMAVGSLGACAHGASVPVFFIFFGKLIN---IIGLAYLFPTTV- 90
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
S V + L +VYLG I + + + +C+M E+ + + R+ + S++
Sbjct: 91 ----------SGRVAKYSLDFVYLGIVILFSSWTEVACWMHTGERQAAKMRQAYLRSMLD 140
Query: 401 QEIAWYDKNTS-GTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
Q+IA +D S G + N + ++ V++ +KVG +++F+ GFA+ F+ W ++L
Sbjct: 141 QDIAVFDTEASTGEVINAITSDILVVQDAISEKVGNFMHYISRFLAGFAIGFSQVWQISL 200
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
+ +++ P + I G Y AG IAEEV+ ++RTV AF G+E +
Sbjct: 201 VTLAIVPLIAIAGGIYAYVTIGLMARVRKSYVKAGEIAEEVIGNVRTVQAFVGEEKAVRT 260
Query: 758 YEDAL----EHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVL 925
Y +AL ++GK+ G+ K G GL S +++ S+ L W + V+ G
Sbjct: 261 YREALLRTYKYGKRGGLAK----GLGLGSMHSVLFLSWALLIWFTSVVVHKNISNGGESF 316
Query: 926 TVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRI 1105
T +V++ ++LGQA +T A AA ++++I+R A S G+T + G I
Sbjct: 317 TTMLNVVIAGLSLGQAAPNISTFLRARTAAYPIFQMIERNTVNKASSKAGRTLPSVDGHI 376
Query: 1106 SVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQIL 1285
V F YP+R DV IL SLD G+ VALVG SG GKST++ L++RFY P G +L
Sbjct: 377 QFRDVRFAYPSRPDVVILDRFSLDFPAGKIVALVGGSGSGKSTVVSLIERFYEPLTGAVL 436
Query: 1286 IDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADF 1465
+D I+D ++K+LRQ +G+V+QEP LF TSI +NI YG+ D S ++I A K + A F
Sbjct: 437 LDGHDIKDLDVKWLRQQIGLVNQEPALFATSIRENILYGKGDASMDEINHAAKLSEAITF 496
Query: 1466 IKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSA 1645
I P+ T VG+RG+Q+SGGQKQRIAI+RA+++NP ILLLDEATSALDAESE VQ A
Sbjct: 497 INHLPDRYETQVGERGIQLSGGQKQRIAISRAILKNPSILLLDEATSALDAESEKSVQEA 556
Query: 1646 LENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLI-EQKGLYHELVHAQVF 1822
L+ GRTT+VIAHRLST+RNAD I V+ +G+++E GTHE L+ + Y L+ Q
Sbjct: 557 LDRVMVGRTTVVIAHRLSTIRNADTIAVVDSGRIVETGTHEQLMANPRSAYASLIQLQEA 616
Query: 1823 ADVDDKPK-------KKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXX 1981
A + +K + + SR+ S+ +F++++ V
Sbjct: 617 AQLQNKQSFSDSASLSRPLSSKYSRELSRTSMGGSFRSEKDSVSRYGTVEAHDEGGHK-- 674
Query: 1982 XXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFS 2161
+ ++ K+ RP+W + + G+ MP F+L +Q + V
Sbjct: 675 -----------SKPVSMKKLYSMIRPDWFFGVSGTVSAFVAGSQMPLFALGVTQAL-VSY 722
Query: 2162 NPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDA 2341
+ K++ A++F A + + FG+ ERLT+R+R +++ +LR +
Sbjct: 723 YMGWETTKREVRKIAVLFCCGAVLTVVFHAIEHLSFGIMGERLTLRVRERMFAAILRNEI 782
Query: 2342 TYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLV 2521
+FD H+ +++RL TDA +++ + R + I + L IAF W++ +V
Sbjct: 783 GWFDDTSHTSSMLSSRLETDATLVRTIVVDRSTILLQNIGMIVTSLIIAFIINWRITLVV 842
Query: 2522 MAIFPFMAVG---QALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYN 2692
+A +P M G + + MK +GG+ K A A EA+ NIRTV A + K+
Sbjct: 843 LATYPLMVSGHISEKMFMKGYGGNL---GKSYLKANMLAAEAVSNIRTVAAFCAEEKVIK 899
Query: 2693 IFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLR 2872
++ L P + + GL YG + F +YA A +G L+ + ++V++
Sbjct: 900 LYADELKEPAKQSFRRGQGAGLFYGVSQFFLFSSYALALWYGSELM--SKEMASFKSVMK 957
Query: 2873 VLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGT-YPQLSGEVK 3049
+ + +G + P+ IK +F +L+ + D + +G ++ G ++
Sbjct: 958 SFMVLIVTALAMGETLAMAPDIIKGNQMVSSVFEILDR--KTDVLIDAGNDVKRVEGVIE 1015
Query: 3050 LNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTV 3229
L V FRYP RP V + +GL++ +K G+++ALVG SG GKSTV+SL+ R YDP+ G V +
Sbjct: 1016 LRGVEFRYPARPEVVVFKGLDLLMKAGKSMALVGMSGSGKSTVLSLILRFYDPIAGKVLI 1075
Query: 3230 DNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHK 3409
D D+R++ K LRKHI LV QEP LF T+I +NI+YG T ++ A AN H
Sbjct: 1076 DGKDIRKVKLKSLRKHIGLVQQEPALFATTIYDNILYGKDGA--TEAEVVDAAKLANAHS 1133
Query: 3410 FIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQV 3589
FI LP+GY TRVGE+G QLSGGQ+QRIAIARA++++P ILLLDEATSALD ESE+ VQ
Sbjct: 1134 FISALPEGYRTRVGERGVQLSGGQRQRIAIARAIVKDPAILLLDEATSALDVESERVVQQ 1193
Query: 3590 ALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKR-GAYFALTQKQS 3766
ALD ++RT ++VAHRLSTI NA I V+++G+++EQG H++LI R GAY L Q
Sbjct: 1194 ALDRVMRNRTTVMVAHRLSTIKNADVISVLQDGKIIEQGAHHQLIENRNGAYHKLVSLQQ 1253
Query: 3767 SNQ 3775
Q
Sbjct: 1254 QQQ 1256
>gi|34913544|ref|NP_918119.1| putative multidrug resistance protein
[Oryza sativa (japonica cultivar-group)]
gi|20146377|dbj|BAB89158.1| putative multidrug resistance protein
[Oryza sativa (japonica cultivar-group)]
Length = 1184
Score = 754 bits (1948), Expect = 0.0
Identities = 433/1191 (36%), Positives = 661/1191 (55%), Gaps = 25/1191 (2%)
Frame = +2
Query: 275 LKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYDKN-TSGTLSNK 451
+ ++YLG G LQ SC+ + E+ + R R + +++RQ+IA++DK +G L +
Sbjct: 1 MNFIYLGVGAGLVSALQVSCWTITGERQAARIRALYLKAILRQDIAFFDKEMNTGQLVER 60
Query: 452 LFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXXX 631
+ + +++ G+K G Q+++ F GGF +AF WLL L+M+S P + + G
Sbjct: 61 MSGDAFLIQDAIGEKAGKCIQLLSTFFGGFIIAFVRGWLLALVMLSSIPPVAVAGAIMSR 120
Query: 632 XXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFL 811
+Y AG + E+ + +IRTV+AFNG++ Y ++ ++ +++ +
Sbjct: 121 LMVKLTIRMQAKYGDAGIVVEQTIGAIRTVVAFNGEKKAINTYNKFIKKAYESALQQGVI 180
Query: 812 IGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQFAT 991
G GL S + ++SY LA W G+ + G V+ V ++M+ +M+LG A
Sbjct: 181 NGLGLGSIISVFFSSYGLAVWYGSRLIVERGYNGGIVINVIMAIMISAMSLGHATSSITA 240
Query: 992 IGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKGVS 1171
+ GAA L+ I+R P+IDA T G + G + + V F+YP+R + + G S
Sbjct: 241 LAGGQGAAYRLFRTIERQPDIDACCTTGDIFEDVKGDVELKNVYFSYPSRPEHLVFDGFS 300
Query: 1172 LDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVS 1351
L G +ALVG SG GKST+I L++RFY+P +G++LID + I N+ +R+ +G+VS
Sbjct: 301 LQVPSGTRMALVGESGSGKSTVISLVERFYDPQSGEVLIDGVDIRRINLGSIRRKIGLVS 360
Query: 1352 QEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQMSGG 1531
QEP LF +I +NI YG+ D + E+I RA++ ANAA FI P GL T+VG+RG+Q+SGG
Sbjct: 361 QEPVLFAGTIRENITYGKEDPTLEEINRAIELANAAKFIDKLPNGLETMVGERGIQLSGG 420
Query: 1532 QKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLSTVRN 1711
QKQRIAIAR +++NP+ILLLDEATSALD ESE +VQ AL RTTI++AHRLSTV+N
Sbjct: 421 QKQRIAIARVIIKNPRILLLDEATSALDMESERVVQEALNKVMLERTTIIVAHRLSTVKN 480
Query: 1712 ADKIIVMKAGQVMEVGTHETLIEQ-KGLYHELVHAQ-----VFADVDDKPK--KKEAERR 1867
AD I V++ G+++E G+HE L+++ +G Y +L+H Q A DD + + + R
Sbjct: 481 ADMISVLQHGKLVEQGSHEELMKKPEGSYCKLIHLQETRQEAVAPNDDPDMIIRNDFDSR 540
Query: 1868 MSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXX-----------XXXXXXXXXXXXXG 2014
+ + R +++F+ S+
Sbjct: 541 II-NSKTRSQNISFRKSTSKSSSFGHSGTHPFTSTCDLSDPMEVHDDQHIKETTDKMSNC 599
Query: 2015 AVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDG 2194
KA++ ++ +PE + G + P F + S I +F P R ++ K+
Sbjct: 600 QEKASILRLFSLNKPEAFVLALGSITAAMHGVIFPVFGILVSSAIKMFYEP-RSELLKNS 658
Query: 2195 HFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPG 2374
MF VL + + LFG+A +L RIRS +++V+ Q+ ++FD P++S G
Sbjct: 659 RLLGSMFPVLGISTFLLIPTEYFLFGLAGGKLVERIRSLTFKSVMYQEISWFDKPENSSG 718
Query: 2375 RITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFP---FMA 2545
I RL+TDA N+K + L F ++++ G IA W++A ++ + P F A
Sbjct: 719 SIGARLSTDALNVKRLVGDNLALNFQTLSTIISGFTIAMVANWKLALIITVVVPLVGFQA 778
Query: 2546 VGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHG 2725
Q + +K +A S E+A + A EA+ IRT+ + + K+ N + +P
Sbjct: 779 YAQMMFLKGFNKNAKS---MFEDATQVATEAVGGIRTITSFCAEQKVMNAYEKKCASPII 835
Query: 2726 GNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGT 2905
I ++ L +GF+ + +F YA F G + V RV F +
Sbjct: 836 QGIRDGVVGALGFGFSFLVFYFAYALCFYVGAKFVHQGTATF--AEVFRVFFVLVLGINE 893
Query: 2906 IGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSG-TYPQLSGEVKLNKVFFRYPER 3082
I ++ E + + +F +L+ + +ID G + G+++ V F+YP R
Sbjct: 894 ISRTSAIGSESRRVNESVVSVFKILDRKSKIDSSNDEGVVIASVRGDIEFQNVCFKYPLR 953
Query: 3083 PAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPK 3262
P V I + L++ + G+T ALVG SG GKSTVISLLER Y+P G + D +L +
Sbjct: 954 PNVQIFKDLSLSIPSGKTAALVGESGSGKSTVISLLERFYEPDAGRILFDGVELETLKVS 1013
Query: 3263 HLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYET 3442
LR I LV+QEP+LF+ +IR NI YG Q G+ + E+I A AN H+FI LPDGY T
Sbjct: 1014 WLRLQIGLVAQEPVLFNDTIRANIAYGKQ-GDASEEEIIAAAEAANAHQFISGLPDGYNT 1072
Query: 3443 RVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTC 3622
VGE+G QLSGGQKQR+AIARA+I++PK+LLLDEATSALD+ESE+ VQ ALD RT
Sbjct: 1073 IVGERGIQLSGGQKQRVAIARAVIKDPKVLLLDEATSALDSESERVVQEALDREVVGRTT 1132
Query: 3623 IVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELI-AKRGAYFALTQKQSSN 3772
+VVAHRLSTI A I V++NG +VE+G H EL+ K G Y +L + SS+
Sbjct: 1133 VVVAHRLSTIKGADIIGVLENGTIVEKGRHEELMQIKGGIYSSLVELSSSS 1183
Score = 362 bits (929), Expect = 4e-98
Identities = 215/592 (36%), Positives = 324/592 (54%), Gaps = 4/592 (0%)
Frame = +2
Query: 44 SIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTAS 223
SI +L+ + +LA+G I + GV P+ I++ + + +F +P S
Sbjct: 604 SILRLFSLNKP-EAFVLALGSITAAMHGVIFPVFGILVSSAIK-------MFYEPRSELL 655
Query: 224 EKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQ 403
+ + + LG F + F + KL R R F SVM Q
Sbjct: 656 KNSRLLGSM----------FPVLGISTFLLIPTEYFLFGLAGGKLVERIRSLTFKSVMYQ 705
Query: 404 EIAWYDK--NTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
EI+W+DK N+SG++ +L + V+ GD + L FQ ++ I GF +A +W L L
Sbjct: 706 EISWFDKPENSSGSIGARLSTDALNVKRLVGDNLALNFQTLSTIISGFTIAMVANWKLAL 765
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
I+ + P + + A +A E + IRT+ +F ++
Sbjct: 766 IITVVVPLVGFQAYAQMMFLKGFNKNAKSMFEDATQVATEAVGGIRTITSFCAEQKVMNA 825
Query: 758 YEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFF 937
YE GI+ + G F++ Y +Y L F+VG FV+ G V VFF
Sbjct: 826 YEKKCASPIIQGIRDGVVGALGFGFSFLVFYFAYALCFYVGAKFVHQGTATFAEVFRVFF 885
Query: 938 SVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNK 1117
+++G + + + + S+++++DR +ID+ + EG + + G I
Sbjct: 886 VLVLGINEISRTSAIGSESRRVNESVVSVFKILDRKSKIDSSNDEGVVIASVRGDIEFQN 945
Query: 1118 VEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDI 1297
V F YP R +V+I K +SL G+T ALVG SG GKST+I LL+RFY PDAG+IL D +
Sbjct: 946 VCFKYPLRPNVQIFKDLSLSIPSGKTAALVGESGSGKSTVISLLERFYEPDAGRILFDGV 1005
Query: 1298 PIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRS-DVSDEDIARALKEANAADFIKT 1474
+E + +LR +G+V+QEP LFN +I NI YG+ D S+E+I A + ANA FI
Sbjct: 1006 ELETLKVSWLRLQIGLVAQEPVLFNDTIRANIAYGKQGDASEEEIIAAAEAANAHQFISG 1065
Query: 1475 FPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALEN 1654
P+G NT+VG+RG+Q+SGGQKQR+AIARA++++PK+LLLDEATSALD+ESE +VQ AL+
Sbjct: 1066 LPDGYNTIVGERGIQLSGGQKQRVAIARAVIKDPKVLLLDEATSALDSESERVVQEALDR 1125
Query: 1655 ASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQK-GLYHELV 1807
GRTT+V+AHRLST++ AD I V++ G ++E G HE L++ K G+Y LV
Sbjct: 1126 EVVGRTTVVVAHRLSTIKGADIIGVLENGTIVEKGRHEELMQIKGGIYSSLV 1177
Score = 350 bits (897), Expect = 2e-94
Identities = 212/527 (40%), Positives = 303/527 (57%), Gaps = 2/527 (0%)
Frame = +2
Query: 2213 FLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRL 2392
F+ L G Q S + + ER RIR+ + +LRQD +FD ++ G++ R+
Sbjct: 3 FIYLGVGAGLVSALQVSCWTITGERQAARIRALYLKAILRQDIAFFDKEMNT-GQLVERM 61
Query: 2393 ATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKY 2572
+ DA I+ AI + G +++ GG IAF GW +A ++++ P +AV A+M +
Sbjct: 62 SGDAFLIQDAIGEKAGKCIQLLSTFFGGFIIAFVRGWLLALVMLSSIPPVAVAGAIMSRL 121
Query: 2573 HGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIR 2752
+ +AG + I IRTV A + K N + + + + + +I
Sbjct: 122 MVKLTIRMQAKYGDAGIVVEQTIGAIRTVVAFNGEKKAINTYNKFIKKAYESALQQGVIN 181
Query: 2753 GLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFP 2932
GL G S+ F +Y A +G LI ++ V+ V+ AI S ++G A S
Sbjct: 182 GLGLGSIISVFFSSYGLAVWYGSRLIVERGY--NGGIVINVIMAIMISAMSLGHATSSIT 239
Query: 2933 EYIKATFAAGLIFNMLEEEPRIDGMTSSGT-YPQLSGEVKLNKVFFRYPERPAVPILQGL 3109
AA +F +E +P ID ++G + + G+V+L V+F YP RP + G
Sbjct: 240 ALAGGQGAAYRLFRTIERQPDIDACCTTGDIFEDVKGDVELKNVYFSYPSRPEHLVFDGF 299
Query: 3110 NVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALV 3289
++ V G +ALVG SG GKSTVISL+ER YDP G V +D D+R++N +R+ I LV
Sbjct: 300 SLQVPSGTRMALVGESGSGKSTVISLVERFYDPQSGEVLIDGVDIRRINLGSIRRKIGLV 359
Query: 3290 SQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQL 3469
SQEP+LF +IRENI YG + + T E+I A AN KFID+LP+G ET VGE+G QL
Sbjct: 360 SQEPVLFAGTIRENITYGKE--DPTLEEINRAIELANAAKFIDKLPNGLETMVGERGIQL 417
Query: 3470 SGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLST 3649
SGGQKQRIAIAR +I+NP+ILLLDEATSALD ESE+ VQ AL+ +RT I+VAHRLST
Sbjct: 418 SGGQKQRIAIARVIIKNPRILLLDEATSALDMESERVVQEALNKVMLERTTIIVAHRLST 477
Query: 3650 IVNAGCIMVVKNGQVVEQGTHNELIAK-RGAYFALTQKQSSNQSGGA 3787
+ NA I V+++G++VEQG+H EL+ K G+Y L Q + Q A
Sbjct: 478 VKNADMISVLQHGKLVEQGSHEELMKKPEGSYCKLIHLQETRQEAVA 524
>gi|50546639|ref|XP_500789.1| hypothetical protein [Yarrowia
lipolytica]
gi|49646655|emb|CAG83040.1| unnamed protein product [Yarrowia
lipolytica CLIB99]
Length = 1304
Score = 754 bits (1946), Expect = 0.0
Identities = 457/1264 (36%), Positives = 679/1264 (53%), Gaps = 22/1264 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
++ L+RY D ++ VG++++ A GV LP+ +II G+++ F
Sbjct: 71 VTFMTLFRYADKFDFFLIMVGLVMAAAAGVCLPIFTIIFGSMTNEFTNFFVY-------- 122
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
A++ F + L +VYL F ++ + E+L+ R R + +++R
Sbjct: 123 ---GASKEHFQSRINHFALYFVYLAVATFGTTAIKTYITVERGERLTARIRANYLKAILR 179
Query: 401 QEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLI 580
Q I ++DK +G ++N++ + ++EG +K+GL +A FI + F LT I
Sbjct: 180 QNIGYFDKLGAGEVTNRITSDTNLIQEGISEKLGLIVSAIASFITALVIGFIKQAKLTGI 239
Query: 581 MMS----LSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYE 748
M+S L+ M IC F + IAEE +SIR ++AF Q
Sbjct: 240 MLSTVFALALSMGICSTFLVKYTKLALEDD----SACSSIAEEAFSSIRNIVAFGSQSRM 295
Query: 749 CKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLT 928
++Y L ++K+ + + + +IY Y LA W G+ V G + G V T
Sbjct: 296 VEKYNVPLASSLHNYLRKNISLAVMVGCLWSLIYIKYALALWEGSRLVAWGETQVGNVTT 355
Query: 929 VFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRIS 1108
V ++M+G+ LG ++G A+ + ++ IDR+PEID EG+ I G I
Sbjct: 356 VLMALMIGAFELGGVAPNLESVGVAIASGKKIFGTIDRVPEIDTQE-EGEKIPDIKGHIV 414
Query: 1109 VNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILI 1288
+ V+F YP+R V+IL+ +L+ PGQTVALVG+SG GKST+I LL+RFY P +G I I
Sbjct: 415 FDNVDFRYPSRPKVQILEDFNLEVLPGQTVALVGASGSGKSTLIGLLERFYQPLSGLITI 474
Query: 1289 DDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYG----RSDVSDED-----IARAL 1441
D + D ++K+LRQ + +VSQEP LFN +I +NI +G + + +D++ + A
Sbjct: 475 DGYNLLDLDVKWLRQHISLVSQEPTLFNCTIYENITFGLIGTQWEHADDEKKMELVEHAC 534
Query: 1442 KEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAE 1621
++ANA DFI+ +G+NT VG+ G+ +SGGQKQRIAIARA++ NP ILLLDEATSALD +
Sbjct: 535 RQANAWDFIQLLTDGINTNVGESGMLLSGGQKQRIAIARAIISNPPILLLDEATSALDTK 594
Query: 1622 SESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHE 1801
SE IVQ AL+ AS RTTIVIAHRLST++NA KI+VM G+++E GTH L+ ++G+Y+
Sbjct: 595 SEGIVQEALDKASENRTTIVIAHRLSTIKNASKIVVMSKGEIIEQGTHAELLAKQGMYYG 654
Query: 1802 LVHAQVFADVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXX 1981
LV AQ K E R +++S QE +
Sbjct: 655 LVDAQ-----------KLTEARPGQKSSSDGEDAPLLIQEDDMKIGKSTTNKSLSSQILA 703
Query: 1982 XXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFS 2161
++ + + +Y R E + LI GA PA +L F+ + F
Sbjct: 704 NKEKPDRDKHLSIAGMVKLLAKYNRNERPFLYVGSFAALINGAGYPALALLFASAMQAFM 763
Query: 2162 -NPD-----RDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRN 2323
+PD R +M K F +F+V ++ + Q G +E L IR V+ +
Sbjct: 764 VSPDMYHWMRSEMNKYSGF---LFMV-GMIELMAYFVQIYCLGWCSEHLVRNIRHSVFSH 819
Query: 2324 VLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGW 2503
+LR D + D ++ G +T+ L+ DA ++ G I +++ ++ G+ IA Y W
Sbjct: 820 LLRMDVAFHDEDDNTTGSLTSTLSKDAQYVQGLGGATFGQILSSLCTIVIGVIIAICYTW 879
Query: 2504 QMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTK 2683
++ + A P + K E + A EA +IRTV LT +
Sbjct: 880 RLGLVCTACVPLIIAAGFFRFWILTHLNLRGKKVYEQSASYACEATTSIRTVVTLTREDY 939
Query: 2684 LYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPEN 2863
+YN + +++ + I + + S+ A F +G L+ K+ +++
Sbjct: 940 VYNDYLHKVESQVADSARANIYSATLFAASQSLNLLISALGFWYGSTLM--KDGIIDTNK 997
Query: 2864 VLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGT---YPQL 3034
++ F + G S+ P+ KA A I NML P +D ++ G + +
Sbjct: 998 FFVAFVSVVFGCQSAGSIFSFTPDMGKAKTATQNIANMLAVLPELDVDSTEGIILDHDNV 1057
Query: 3035 SGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLE 3214
G++ V FRYP RP VPIL+GLN+++K GQ +ALVG SGCGKST I+L+ER YD L
Sbjct: 1058 RGDISFEDVRFRYPTRPQVPILRGLNLNIKKGQYVALVGSSGCGKSTTIALIERFYDVLS 1117
Query: 3215 GAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSK 3394
GAV +D D+R +N R I+LV QEP+LF ++RENI+ G + T E++ A
Sbjct: 1118 GAVKLDGVDIRDININSYRSCISLVQQEPVLFSGTVRENILLGSLRDDVTEEEMIEAAEM 1177
Query: 3395 ANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESE 3574
ANIH F+ LPDGY+T G KG+ LSGGQKQR+AIARALIRNPKILLLDEATSALD+ESE
Sbjct: 1178 ANIHSFVMSLPDGYDTYCGSKGSLLSGGQKQRVAIARALIRNPKILLLDEATSALDSESE 1237
Query: 3575 KQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALT 3754
K VQ ALD AAK RT I VAHRLSTI NA I V + G+V+E GTH EL+A + Y+ L
Sbjct: 1238 KIVQAALDQAAKGRTTIAVAHRLSTIQNADIIYVFEEGRVLESGTHQELLANKSKYYELV 1297
Query: 3755 QKQS 3766
+ Q+
Sbjct: 1298 KLQA 1301
Score = 343 bits (881), Expect = 1e-92
Identities = 229/579 (39%), Positives = 317/579 (54%), Gaps = 21/579 (3%)
Frame = +2
Query: 2105 GAVMPAFSLFFSQIINVFSN-----PDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLF 2269
G +P F++ F + N F+N ++ + + +AL F+ LA + + +
Sbjct: 99 GVCLPIFTIIFGSMTNEFTNFFVYGASKEHFQSRINHFALYFVYLAVATFGTTAIKTYIT 158
Query: 2270 GVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIF 2449
ERLT RIR+ + +LRQ+ YFD K G +T R+ +D I+ I +LG I
Sbjct: 159 VERGERLTARIRANYLKAILRQNIGYFD--KLGAGEVTNRITSDTNLIQEGISEKLGLIV 216
Query: 2450 NAIASVGGGLGIAFYYGWQMAFL----VMAIFPFMAVGQALMMKYHGGSATSDAKEMENA 2617
+AIAS L I F ++ + V A+ M + ++KY T A E ++A
Sbjct: 217 SAIASFITALVIGFIKQAKLTGIMLSTVFALALSMGICSTFLVKY-----TKLALEDDSA 271
Query: 2618 -GKTAMEAIENIRTVQALTLQTKL---YNI-FCSHLDAPHGGNISKAIIRGLTYGFANSI 2782
A EA +IR + A Q+++ YN+ S L NIS A++ G + S+
Sbjct: 272 CSSIAEEAFSSIRNIVAFGSQSRMVEKYNVPLASSLHNYLRKNISLAVMVGCLW----SL 327
Query: 2783 QFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAG 2962
+ YA A G L+ + NV VL A+ +G A A +
Sbjct: 328 IYIKYALALWEGSRLVAWGET--QVGNVTTVLMALMIGAFELGGVAPNLESVGVAIASGK 385
Query: 2963 LIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLA 3142
IF ++ P ID P + G + + V FRYP RP V IL+ N+ V PGQT+A
Sbjct: 386 KIFGTIDRVPEIDTQEEGEKIPDIKGHIVFDNVDFRYPSRPKVQILEDFNLEVLPGQTVA 445
Query: 3143 LVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSI 3322
LVG SG GKST+I LLER Y PL G +T+D +L ++ K LR+HI+LVSQEP LF+ +I
Sbjct: 446 LVGASGSGKSTLIGLLERFYQPLSGLITIDGYNLLDLDVKWLRQHISLVSQEPTLFNCTI 505
Query: 3323 RENIVYGLQPGEYTH-------EQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQ 3481
ENI +GL ++ H E +E AC +AN FI L DG T VGE G LSGGQ
Sbjct: 506 YENITFGLIGTQWEHADDEKKMELVEHACRQANAWDFIQLLTDGINTNVGESGMLLSGGQ 565
Query: 3482 KQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNA 3661
KQRIAIARA+I NP ILLLDEATSALDT+SE VQ ALD A+++RT IV+AHRLSTI NA
Sbjct: 566 KQRIAIARAIISNPPILLLDEATSALDTKSEGIVQEALDKASENRTTIVIAHRLSTIKNA 625
Query: 3662 GCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSSNQS 3778
I+V+ G+++EQGTH EL+AK+G Y+ L Q ++
Sbjct: 626 SKIVVMSKGEIIEQGTHAELLAKQGMYYGLVDAQKLTEA 664
>gi|21464386|gb|AAM51996.1| RE14657p [Drosophila melanogaster]
Length = 1302
Score = 753 bits (1943), Expect = 0.0
Identities = 454/1276 (35%), Positives = 694/1276 (53%), Gaps = 32/1276 (2%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
I+ +L+R+++ + L G I+ C + LP + II + V F ++
Sbjct: 31 IAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIYSEFTSMLVDRAMQFGTSSNVH 90
Query: 221 SEKA---------AARAEFSHEVIQNCLKYVYL----GCGIFAAGFLQASCFMVICEKLS 361
+ A+R E + + + + Y L +F +G F ++ +
Sbjct: 91 ALPLFGGGKTLTNASREENNEALYDDSISYGILLTIASVVMFISGIFSVDVFNMVALRQV 150
Query: 362 NRFRRQFFHSVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGF 541
R R + F SV+RQ+I W+D + + + D++E++R+G +KVG ++ FI
Sbjct: 151 TRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDGISEKVGHFVYLVVGFIITV 210
Query: 542 AVAFTYDWLLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTV 721
A++F+Y W LTL + S P +++ + YA AG +AEE+L+SIRTV
Sbjct: 211 AISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILSSIRTV 270
Query: 722 IAFNGQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSG 901
++F G++ E +RYE+ L +K K G A ++Y S AFW G N +
Sbjct: 271 VSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNLIIDD 330
Query: 902 R------LESGTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAY 1063
R ++ FF +++G+ + + + TA G A +L++VID +ID
Sbjct: 331 RDVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPL 390
Query: 1064 STEGQTPSK-ISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTII 1240
ST+G+ + + G + V F YP+R +V + +G+++ + GQTVALVGSSGCGKST +
Sbjct: 391 STDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCV 450
Query: 1241 QLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSD 1420
QLLQRFY+P G +L+DD+ I +NI++LR + VV QEP LF +I QNI YG+ +
Sbjct: 451 QLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQ 510
Query: 1421 EDIARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEA 1600
++I A +A A +FI PE +++G+RG Q+SGGQKQRIAIARAL++NPKILLLDEA
Sbjct: 511 KEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEA 570
Query: 1601 TSALDAESESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIE 1780
TSALD +SE VQ AL+ AS+GRTTIV++HRLS +R ADKI+ + G+V+E G+H+ L+
Sbjct: 571 TSALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMA 630
Query: 1781 QKGLYHELVHAQVFADVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXX 1960
+G Y+ +V A D+ K+ E ++Q S +F+T +
Sbjct: 631 LEGAYYNMVRAGDINMPDEVEKEDSIED--TKQKSLALFEKSFETSPLNFEKGQKNSVQF 688
Query: 1961 XXXXXXXXXXXXXXXXXGA--VKANLF----KILRYARPEWIYXXXXXXXXLIQGAVMPA 2122
A K N F +IL+ A+ EW Y + G + PA
Sbjct: 689 EEPIIKALIKDTNAQSAEAPPEKPNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPA 748
Query: 2123 FSLFFSQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRI 2302
F++ F + + D + + + L LA + G Q LF A LT R+
Sbjct: 749 FAVIFGEFYAALAEKDPEDALRRTAVLSWACLGLAFLTGLVCFLQTYLFNYAGIWLTTRM 808
Query: 2303 RSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLG 2482
R+ + ++ Q+ +FD +S G ++ RL+ +A +I+ AI Y L + A+++ +
Sbjct: 809 RAMTFNAMVNQEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVS 868
Query: 2483 IAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQ 2662
+A YY W++A L +A P + L K + + + +E A + A E+I NIRTV
Sbjct: 869 VAMYYNWKLALLCLANCPIIVGSVILEAKMMSNAVVREKQVIEEACRIATESITNIRTVA 928
Query: 2663 ALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKN 2842
L + + + + K RG+ + FF YA A +G L+ +
Sbjct: 929 GLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTMQASAFFAYAVALCYGGVLVSEGQ 988
Query: 2843 VLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRID---GMTS 3013
+ +++++V + + + + ++ P + A A +F +L+ +P+I G
Sbjct: 989 LPF--QDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQILDRKPKIQSPMGTIK 1046
Query: 3014 SGTYPQLS--GEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISL 3187
+ QL+ V+ + FRYP RP IL GL++ V GQT+ALVG SGCGKST + L
Sbjct: 1047 NTLAKQLNLFEGVRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQL 1106
Query: 3188 LERLYDPLEGAVTVDNNDLR-QMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYT 3364
L+R YDP EG + +D++D++ + +R + +VSQEP LF+ SI ENIVYG +
Sbjct: 1107 LQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIVYGDNRRSVS 1166
Query: 3365 HEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDE 3544
+I A AN H FI LP+GY+TR+G +GTQLSGGQKQRIAIARAL+RNPKILLLDE
Sbjct: 1167 MVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDE 1226
Query: 3545 ATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELI 3724
ATSALD +SE+ VQ ALD A RTCIV+AHRLST+ NA I V++NGQVVEQG H +LI
Sbjct: 1227 ATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLI 1286
Query: 3725 AKRGAYFALTQKQSSN 3772
++ G Y L + Q +
Sbjct: 1287 SQGGIYAKLHKTQKDH 1302
>gi|17136662|ref|NP_476831.1| CG10181-PA [Drosophila melanogaster]
gi|17380460|sp|Q00748|MDR5_DROME Multidrug resistance protein homolog
65 (P-glycoprotein 65)
gi|7295351|gb|AAF50669.1| CG10181-PA [Drosophila melanogaster]
gi|7767568|gb|AAF69146.1| P-glycoprotein [Drosophila melanogaster]
gi|7767570|gb|AAF69147.1| P-glycoprotein [Drosophila melanogaster]
Length = 1302
Score = 751 bits (1939), Expect = 0.0
Identities = 453/1276 (35%), Positives = 693/1276 (53%), Gaps = 32/1276 (2%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
I+ +L+R+++ + L G I+ C + LP + II + V F ++
Sbjct: 31 IAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIYSEFTSMLVDRAMQFGTSSNVH 90
Query: 221 SEKA---------AARAEFSHEVIQNCLKYVYL----GCGIFAAGFLQASCFMVICEKLS 361
+ A+R E + + + + Y L +F +G F ++ +
Sbjct: 91 ALPLFGGGKTLTNASREENNEALYDDSISYGILLTIASVVMFISGIFSVDVFNMVALRQV 150
Query: 362 NRFRRQFFHSVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGF 541
R R + F SV+RQ+I W+D + + + D++E++R+G +KVG ++ FI
Sbjct: 151 TRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDGISEKVGHFVYLVVGFIITV 210
Query: 542 AVAFTYDWLLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTV 721
A++F+Y W LTL + S P +++ + YA AG +AEE+L+SIRTV
Sbjct: 211 AISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILSSIRTV 270
Query: 722 IAFNGQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSG 901
++F G++ E +RYE+ L +K K G A ++Y S AFW G N +
Sbjct: 271 VSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNLIIDD 330
Query: 902 R------LESGTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAY 1063
R ++ FF +++G+ + + + TA G A +L++VID +ID
Sbjct: 331 RNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPL 390
Query: 1064 STEGQTPSK-ISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTII 1240
ST+G+ + + G + V F YP+R +V + +G+++ + GQTVALVGSSGCGKST +
Sbjct: 391 STDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCV 450
Query: 1241 QLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSD 1420
QLLQRFY+P G +L+DD+ I +NI++LR + VV QEP LF +I QNI YG+ +
Sbjct: 451 QLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQ 510
Query: 1421 EDIARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEA 1600
++I A +A A +FI PE +++G+RG Q+SGGQKQRIAIARAL++NPKILLLDEA
Sbjct: 511 KEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEA 570
Query: 1601 TSALDAESESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIE 1780
TSALD +SE VQ AL+ AS+GRTTIV++HRLS +R ADKI+ + G+V+E G+H+ L+
Sbjct: 571 TSALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMA 630
Query: 1781 QKGLYHELVHAQVFADVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXX 1960
+G Y+ +V A D+ K+ E ++Q S +F+T +
Sbjct: 631 LEGAYYNMVRAGDINMPDEVEKEDSIED--TKQKSLALFEKSFETSPLNFEKGQKNSVQF 688
Query: 1961 XXXXXXXXXXXXXXXXXGA--VKANLF----KILRYARPEWIYXXXXXXXXLIQGAVMPA 2122
A K N F +IL+ A+ EW Y + G + PA
Sbjct: 689 EEPIIKALIKDTNAQSAEAPPEKPNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPA 748
Query: 2123 FSLFFSQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRI 2302
F++ F + + D + + + L LA + G Q LF A LT R+
Sbjct: 749 FAVIFGEFYAALAEKDPEDALRRTAVLSWACLGLAFLTGLVCFLQTYLFNYAGIWLTTRM 808
Query: 2303 RSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLG 2482
R+ + ++ Q+ +FD +S G ++ RL+ +A +I+ AI Y L + A+++ +
Sbjct: 809 RAMTFNAMVNQEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVS 868
Query: 2483 IAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQ 2662
+A YY W++A L +A P + L K + + + +E A + A E+I NIRTV
Sbjct: 869 VAMYYNWKLALLCLANCPIIVGSVILEAKMMSNAVVREKQVIEEACRIATESITNIRTVA 928
Query: 2663 ALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKN 2842
L + + + + K RG+ + FF YA A +G L+ +
Sbjct: 929 GLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTMQASAFFAYAVALCYGGVLVSEGQ 988
Query: 2843 VLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRID---GMTS 3013
+ +++++V + + + + ++ P + A A +F +L+ +P+I G
Sbjct: 989 LPF--QDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQILDRKPKIQSPMGTIK 1046
Query: 3014 SGTYPQLS--GEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISL 3187
+ QL+ V+ + FRYP RP IL GL++ V GQT+ALVG SGCGKST + L
Sbjct: 1047 NTLAKQLNLFEGVRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQL 1106
Query: 3188 LERLYDPLEGAVTVDNNDLR-QMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYT 3364
L+R YDP EG + +D++D++ + +R + +VSQEP LF+ SI ENI YG +
Sbjct: 1107 LQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGDNRRSVS 1166
Query: 3365 HEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDE 3544
+I A AN H FI LP+GY+TR+G +GTQLSGGQKQRIAIARAL+RNPKILLLDE
Sbjct: 1167 MVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDE 1226
Query: 3545 ATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELI 3724
ATSALD +SE+ VQ ALD A RTCIV+AHRLST+ NA I V++NGQVVEQG H +LI
Sbjct: 1227 ATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLI 1286
Query: 3725 AKRGAYFALTQKQSSN 3772
++ G Y L + Q +
Sbjct: 1287 SQGGIYAKLHKTQKDH 1302
>gi|103252|pir||B41249 multidrug resistance protein homolog Mdr65 -
fruit fly (Drosophila melanogaster)
gi|157875|gb|AAA28680.1| P-glycoprotein
Length = 1302
Score = 750 bits (1937), Expect = 0.0
Identities = 452/1276 (35%), Positives = 694/1276 (53%), Gaps = 32/1276 (2%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
I+ +L+R+++ + L G I+ C + LP + II + V F ++
Sbjct: 31 IAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIYSEFTSMLVDRAMQFGTSSNVH 90
Query: 221 SEKA---------AARAEFSHEVIQNCLKYVYL----GCGIFAAGFLQASCFMVICEKLS 361
+ A+R E + + + + Y L +F +G F ++ +
Sbjct: 91 ALPLFGGGKTLTNASREENNEALYDDSISYGILLTIASVVMFISGIFSVDVFNMVALRQV 150
Query: 362 NRFRRQFFHSVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGF 541
R R + F SV+RQ+I W+D + + + D++E++R+G +KVG ++ FI
Sbjct: 151 TRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDGISEKVGHFVYLVVGFIITV 210
Query: 542 AVAFTYDWLLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTV 721
A++F+Y W LTL + S P +++ + YA AG +AEE+L+SIRTV
Sbjct: 211 AISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILSSIRTV 270
Query: 722 IAFNGQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSG 901
++F G++ E +RYE+ L +K K G A ++Y S AFW G N +
Sbjct: 271 VSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNLIIDD 330
Query: 902 R------LESGTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAY 1063
R ++ FF +++G+ + + + +A G A +L++VID +ID
Sbjct: 331 RNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFASARGCATNLFKVIDLTSKIDPL 390
Query: 1064 STEGQTPSK-ISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTII 1240
ST+G+ + + G + V F YP+R +V + +G+++ + GQTVALVGSSGCGKST +
Sbjct: 391 STDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCV 450
Query: 1241 QLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSD 1420
QLLQRFY+P G +L+DD+ I +NI++LR + VV QEP LF +I QNI YG+ +
Sbjct: 451 QLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQ 510
Query: 1421 EDIARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEA 1600
++I A +A A +FI PE +++G+RG Q+SGGQKQRIAIARAL++NPKILLLDEA
Sbjct: 511 KEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEA 570
Query: 1601 TSALDAESESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIE 1780
TSALD +SE VQ AL+ AS+GRTTIV++HRLS +R ADKI+ + G+V+E G+H+ L+
Sbjct: 571 TSALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMA 630
Query: 1781 QKGLYHELVHAQVFADVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXX 1960
+G Y+ +V A D+ K+ E ++Q S +F+T ++
Sbjct: 631 LEGAYYNMVRAGDINMPDEVEKEDSIED--TKQKSLALFEKSFETSPLNLEKGQKNSVQF 688
Query: 1961 XXXXXXXXXXXXXXXXXGA--VKANLF----KILRYARPEWIYXXXXXXXXLIQGAVMPA 2122
A K N F +IL+ A+ EW Y + G + PA
Sbjct: 689 EEPIIKALIKDTNAQSAEAPPEKPNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPA 748
Query: 2123 FSLFFSQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRI 2302
F++ F + + D + + + L LA + G Q LF A LT R+
Sbjct: 749 FAVIFGEFYAALAEKDPEDALRRTAVLSWACLGLAFLTGLVCFLQTYLFNYAGIWLTTRM 808
Query: 2303 RSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLG 2482
R+ + ++ Q+ +FD +S G ++ RL+ +A +I+ AI Y L + A+++ +
Sbjct: 809 RAMTFNAMVNQEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVS 868
Query: 2483 IAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQ 2662
+A YY W++A L +A P + L K + + + +E A + A E+I NIRTV
Sbjct: 869 VAMYYNWKLALLCLANCPIIVGSVILEAKMMSNAVVREKQVIEEACRIATESITNIRTVA 928
Query: 2663 ALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKN 2842
L + + + + K RG+ + FF YA A +G L+ +
Sbjct: 929 GLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTMQASAFFAYAVALCYGGVLVSEGQ 988
Query: 2843 VLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRID---GMTS 3013
+ +++++V + + + + ++ P + A A +F +L+ +P+I G
Sbjct: 989 LPF--QDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQILDRKPKIQSPMGTIK 1046
Query: 3014 SGTYPQLS--GEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISL 3187
+ QL+ V+ + FRYP RP IL GL++ V GQT+ALVG SGCGKST + L
Sbjct: 1047 NTLAKQLNLFEGVRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQL 1106
Query: 3188 LERLYDPLEGAVTVDNNDLR-QMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYT 3364
L+R YDP EG + +D++D++ + +R + +VSQEP LF+ SI ENI YG +
Sbjct: 1107 LQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGDNRRSVS 1166
Query: 3365 HEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDE 3544
+I A AN H FI LP+GY+TR+G +GTQLSGGQKQRIAIARAL+RNPKILLLDE
Sbjct: 1167 MVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDE 1226
Query: 3545 ATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELI 3724
ATSALD +SE+ VQ ALD A RTCIV+AHRLST+ NA I V++NGQVVEQG H +LI
Sbjct: 1227 ATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLI 1286
Query: 3725 AKRGAYFALTQKQSSN 3772
++ G Y L + Q +
Sbjct: 1287 SQGGIYAKLHKTQKDH 1302
>gi|20466380|gb|AAM20507.1| P-glycoprotein-2 [Arabidopsis thaliana]
Length = 1233
Score = 749 bits (1935), Expect = 0.0
Identities = 450/1252 (35%), Positives = 683/1252 (53%), Gaps = 7/1252 (0%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+S+ +L+ + D +++ +G + +C G +P+ I G + +G +L P
Sbjct: 20 VSLLKLFSFADFYDCVLMTLGSVGACIHGASVPIFFIFFGKLIN---IIGLAYLFPKQA- 75
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
SH V + L +VYL I + +L+ +C+M E+ + + RR + S++
Sbjct: 76 ----------SHRVAKYSLDFVYLSVAILFSSWLEVACWMHTGERQAAKMRRAYLRSMLS 125
Query: 401 QEIAWYDKNTS-GTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
Q+I+ +D S G + + + ++ V++ +KVG +++FI GFA+ FT W ++L
Sbjct: 126 QDISLFDTEASTGEVISAITSDILVVQDALSEKVGNFLHYISRFIAGFAIGFTSVWQISL 185
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
+ +S+ P + + G Y AG IAEEV+ ++RTV AF G+E +
Sbjct: 186 VTLSIVPLIALAGGIYAFVAIGLIARVRKSYIKAGEIAEEVIGNVRTVQAFTGEERAVRL 245
Query: 758 YEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFF 937
Y +ALE+ K G K G GL S +++ S+ L W + V+ + G T
Sbjct: 246 YREALENTYKYGRKAGLTKGLGLGSMHCVLFLSWALLVWFTSVVVHKDIADGGKSFTTML 305
Query: 938 SVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNK 1117
+V++ ++LGQA + A AA ++++I+R + G+ K+ G I
Sbjct: 306 NVVIAGLSLGQAAPDISAFVRAKAAAYPIFKMIERNTVTKTSAKSGRKLGKVDGHIQFKD 365
Query: 1118 VEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDI 1297
F+YP+R DV I ++L G+ VALVG SG GKST+I L++RFY P +G +L+D
Sbjct: 366 ATFSYPSRPDVVIFDRLNLAIPAGKIVALVGGSGSGKSTVISLIERFYEPISGAVLLDGN 425
Query: 1298 PIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTF 1477
I + +IK+LR +G+V+QEP LF T+I +NI YG+ D + E+I RA K + A FI
Sbjct: 426 NISELDIKWLRGQIGLVNQEPALFATTIRENILYGKDDATAEEITRAAKLSEAISFINNL 485
Query: 1478 PEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENA 1657
PEG T VG+RG+Q+SGGQKQRIAI+RA+V+NP ILLLDEATSALDAESE VQ AL+
Sbjct: 486 PEGFETQVGERGIQLSGGQKQRIAISRAIVKNPSILLLDEATSALDAESEKSVQEALDRV 545
Query: 1658 SRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQ-KGLYHELVHAQVFADVD 1834
GRTT+V+AHRLSTVRNAD I V+ G+++E G HE LI G Y L+ Q A +
Sbjct: 546 MVGRTTVVVAHRLSTVRNADIIAVVHEGKIVEFGNHENLISNPDGAYSSLLRLQETASLQ 605
Query: 1835 DKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXG 2014
P +T R S+ + + S+
Sbjct: 606 RNPS--------LNRTLSRPHSIKYSRELSR-------TRSSFCSERESVTRPDGADPSK 650
Query: 2015 AVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQ-IINVFSNPDRDQMKKD 2191
VK + ++ RP+W+Y I G+ MP F+L SQ +++ +S D Q K+
Sbjct: 651 KVKVTVGRLYSMIRPDWMYGVCGTICAFIAGSQMPLFALGVSQALVSYYSGWDETQ--KE 708
Query: 2192 GHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSP 2371
A++F + + + FG ERLT+R+R ++R +L+ + +FD ++
Sbjct: 709 IKKIAILFCCASVITLIVYTIEHICFGTMGERLTLRVRENMFRAILKNEIGWFDEVDNAS 768
Query: 2372 GRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVG 2551
+ +RL +DA +K+ + R + + V IAF W++ +V+A +P + G
Sbjct: 769 SMLASRLESDATLLKTIVVDRSTILLQNLGLVVTSFIIAFILNWRLTLVVLATYPLVISG 828
Query: 2552 ---QALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPH 2722
+ L M+ +GG K A A E++ NIRTV A + K+ ++ L P
Sbjct: 829 HISEKLFMQGYGGDLN---KAYLKANMLAGESVSNIRTVAAFCAEEKILELYSRELLEPS 885
Query: 2723 GGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFG 2902
+ + I GL YG + F +Y A +G L+ DK L ++V++ + +
Sbjct: 886 KSSFRRGQIAGLFYGVSQFFIFSSYGLALWYGSTLM-DKG-LAGFKSVMKTFMVLIVTAL 943
Query: 2903 TIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVFFRYPER 3082
+G + P+ +K +F +L+ + +I G TS + G ++L V F YP R
Sbjct: 944 AMGETLALAPDLLKGNQMVASVFEILDRKTQIVGETSE-ELNNVEGTIELKGVHFSYPSR 1002
Query: 3083 PAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPK 3262
P V I + ++ V+ G+++ALVG SG GKS+VISL+ R YDP G V ++ D+++++ K
Sbjct: 1003 PDVVIFRDFDLIVRAGKSMALVGQSGSGKSSVISLILRFYDPTAGKVMIEGKDIKKLDLK 1062
Query: 3263 HLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYET 3442
LRKHI LV QEP LF T+I ENI+YG G E +E+A AN H FI LP+GY T
Sbjct: 1063 ALRKHIGLVQQEPALFATTIYENILYG-NEGASQSEVVESA-MLANAHSFITSLPEGYST 1120
Query: 3443 RVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTC 3622
+VGE+G Q+SGGQ+QRIAIARA+++NP ILLLDEATSALD ESE+ VQ ALD +RT
Sbjct: 1121 KVGERGVQMSGGQRQRIAIARAILKNPAILLLDEATSALDVESERVVQQALDRLMANRTT 1180
Query: 3623 IVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIA-KRGAYFALTQKQSSNQ 3775
+VVAHRLSTI NA I V+ G++VEQG+H +L+ K G YF L Q Q
Sbjct: 1181 VVVAHRLSTIKNADTISVLHGGKIVEQGSHRKLVLNKSGPYFKLISLQQQQQ 1232
>gi|15236067|ref|NP_194326.1| multidrug resistance P-glycoprotein,
putative [Arabidopsis thaliana]
gi|7442648|pir||T04251 P-glycoprotein 2 - Arabidopsis thaliana
gi|2108252|emb|CAA71277.1| P-glycoprotein-2 [Arabidopsis thaliana]
gi|2108254|emb|CAA71276.1| P-glycoprotein-2 [Arabidopsis thaliana]
gi|4538925|emb|CAB39661.1| P-glycoprotein-2 (pgp2) [Arabidopsis
thaliana]
gi|7269447|emb|CAB79451.1| P-glycoprotein-2 (pgp2) [Arabidopsis
thaliana]
Length = 1233
Score = 749 bits (1935), Expect = 0.0
Identities = 450/1252 (35%), Positives = 683/1252 (53%), Gaps = 7/1252 (0%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+S+ +L+ + D +++ +G + +C G +P+ I G + +G +L P
Sbjct: 20 VSLLKLFSFADFYDCVLMTLGSVGACIHGASVPIFFIFFGKLIN---IIGLAYLFPKQA- 75
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
SH V + L +VYL I + +L+ +C+M E+ + + RR + S++
Sbjct: 76 ----------SHRVAKYSLDFVYLSVAILFSSWLEVACWMHTGERQAAKMRRAYLRSMLS 125
Query: 401 QEIAWYDKNTS-GTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
Q+I+ +D S G + + + ++ V++ +KVG +++FI GFA+ FT W ++L
Sbjct: 126 QDISLFDTEASTGEVISAITSDILVVQDALSEKVGNFLHYISRFIAGFAIGFTSVWQISL 185
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
+ +S+ P + + G Y AG IAEEV+ ++RTV AF G+E +
Sbjct: 186 VTLSIVPLIALAGGIYAFVAIGLIARVRKSYIKAGEIAEEVIGNVRTVQAFTGEERAVRL 245
Query: 758 YEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFF 937
Y +ALE+ K G K G GL S +++ S+ L W + V+ + G T
Sbjct: 246 YREALENTYKYGRKAGLTKGLGLGSMHCVLFLSWALLVWFTSVVVHKDIADGGKSFTTML 305
Query: 938 SVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNK 1117
+V++ ++LGQA + A AA ++++I+R + G+ K+ G I
Sbjct: 306 NVVIAGLSLGQAAPDISAFVRAKAAAYPIFKMIERNTVTKTSAKSGRKLGKVDGHIQFKD 365
Query: 1118 VEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDI 1297
F+YP+R DV I ++L G+ VALVG SG GKST+I L++RFY P +G +L+D
Sbjct: 366 ATFSYPSRPDVVIFDRLNLAIPAGKIVALVGGSGSGKSTVISLIERFYEPISGAVLLDGN 425
Query: 1298 PIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTF 1477
I + +IK+LR +G+V+QEP LF T+I +NI YG+ D + E+I RA K + A FI
Sbjct: 426 NISELDIKWLRGQIGLVNQEPALFATTIRENILYGKDDATAEEITRAAKLSEAISFINNL 485
Query: 1478 PEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENA 1657
PEG T VG+RG+Q+SGGQKQRIAI+RA+V+NP ILLLDEATSALDAESE VQ AL+
Sbjct: 486 PEGFETQVGERGIQLSGGQKQRIAISRAIVKNPSILLLDEATSALDAESEKSVQEALDRV 545
Query: 1658 SRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQ-KGLYHELVHAQVFADVD 1834
GRTT+V+AHRLSTVRNAD I V+ G+++E G HE LI G Y L+ Q A +
Sbjct: 546 MVGRTTVVVAHRLSTVRNADIIAVVHEGKIVEFGNHENLISNPDGAYSSLLRLQETASLQ 605
Query: 1835 DKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXG 2014
P +T R S+ + + S+
Sbjct: 606 RNPS--------LNRTLSRPHSIKYSRELSR-------TRSSFCSERESVTRPDGADPSK 650
Query: 2015 AVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQ-IINVFSNPDRDQMKKD 2191
VK + ++ RP+W+Y I G+ MP F+L SQ +++ +S D Q K+
Sbjct: 651 KVKVTVGRLYSMIRPDWMYGVCGTICAFIAGSQMPLFALGVSQALVSYYSGWDETQ--KE 708
Query: 2192 GHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSP 2371
A++F + + + FG ERLT+R+R ++R +L+ + +FD ++
Sbjct: 709 IKKIAILFCCASVITLIVYTIEHICFGTMGERLTLRVRENMFRAILKNEIGWFDEVDNTS 768
Query: 2372 GRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVG 2551
+ +RL +DA +K+ + R + + V IAF W++ +V+A +P + G
Sbjct: 769 SMLASRLESDATLLKTIVVDRSTILLQNLGLVVTSFIIAFILNWRLTLVVLATYPLVISG 828
Query: 2552 ---QALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPH 2722
+ L M+ +GG K A A E++ NIRTV A + K+ ++ L P
Sbjct: 829 HISEKLFMQGYGGDLN---KAYLKANMLAGESVSNIRTVAAFCAEEKILELYSRELLEPS 885
Query: 2723 GGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFG 2902
+ + I GL YG + F +Y A +G L+ DK L ++V++ + +
Sbjct: 886 KSSFRRGQIAGLFYGVSQFFIFSSYGLALWYGSTLM-DKG-LAGFKSVMKTFMVLIVTAL 943
Query: 2903 TIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVFFRYPER 3082
+G + P+ +K +F +L+ + +I G TS + G ++L V F YP R
Sbjct: 944 AMGETLALAPDLLKGNQMVASVFEILDRKTQIVGETSE-ELNNVEGTIELKGVHFSYPSR 1002
Query: 3083 PAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPK 3262
P V I + ++ V+ G+++ALVG SG GKS+VISL+ R YDP G V ++ D+++++ K
Sbjct: 1003 PDVVIFRDFDLIVRAGKSMALVGQSGSGKSSVISLILRFYDPTAGKVMIEGKDIKKLDLK 1062
Query: 3263 HLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYET 3442
LRKHI LV QEP LF T+I ENI+YG G E +E+A AN H FI LP+GY T
Sbjct: 1063 ALRKHIGLVQQEPALFATTIYENILYG-NEGASQSEVVESA-MLANAHSFITSLPEGYST 1120
Query: 3443 RVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTC 3622
+VGE+G Q+SGGQ+QRIAIARA+++NP ILLLDEATSALD ESE+ VQ ALD +RT
Sbjct: 1121 KVGERGVQMSGGQRQRIAIARAILKNPAILLLDEATSALDVESERVVQQALDRLMANRTT 1180
Query: 3623 IVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIA-KRGAYFALTQKQSSNQ 3775
+VVAHRLSTI NA I V+ G++VEQG+H +L+ K G YF L Q Q
Sbjct: 1181 VVVAHRLSTIKNADTISVLHGGKIVEQGSHRKLVLNKSGPYFKLISLQQQQQ 1232
>gi|393116|gb|AAA93553.1| P-glycoprotein 5
Length = 1301
Score = 749 bits (1935), Expect = 0.0
Identities = 449/1280 (35%), Positives = 698/1280 (54%), Gaps = 39/1280 (3%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFV-TLG-TIFLDPNS 214
+S+ +L++Y+ +D ++L VG+I S GV PLM ++MG++ +++ T G +D
Sbjct: 34 VSVIKLFKYSDWIDMILLVVGLISSIGNGVMQPLMMLLMGDMVNSYIYTPGDNTIIDEEV 93
Query: 215 TASEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSV 394
+ + V++N + Y + FL+ V+ ++ R RR +F S+
Sbjct: 94 NHMIVEGVKESENKVVVKNGIYYEVIS---MVLSFLRTFSLFVVSQREGIRVRRLYFKSL 150
Query: 395 MRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLT 574
+RQ+ WYD SG L+ ++ +++ ++G G K G+ FQ+++ I G + F W L
Sbjct: 151 LRQDATWYDFQESGELTARIATDIKNYQDGIGPKFGMIFQIISMVITGCVIEFKKCWDLA 210
Query: 575 LIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECK 754
L++++ PF + AG IAEE + +IRTV + N +
Sbjct: 211 LVVLATVPFSSFSFTIFQIIGMKYETKALKVFGAAGAIAEETIGNIRTVQSLNQKNEFIA 270
Query: 755 RYEDALEHGKK-TGIKKSFL---IGAGLASFFVIIYASYCLAFWVGTNFVY----SGRLE 910
Y++ ++ + GIK L I + +FF+I ASY L W G+ + S +
Sbjct: 271 EYQEKIKQNEHFNGIKGQCLMSWIRFSVITFFMI--ASYALGSWYGSLVIRGKGGSKGVF 328
Query: 911 SGTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSK 1090
+G VLTVF SV+ S L + + +A ++ IDRIP+ID S G+ P++
Sbjct: 329 AGHVLTVFLSVLSASQTLSMIAILLNLLFSDKASAYKIFTTIDRIPDIDCQSIGGECPTE 388
Query: 1091 ISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPD 1270
+G I V+F YPTR +LKG+ ++ + G+T+ALVG+SGCGKST IQL+QR Y P+
Sbjct: 389 CNGNIRFVDVQFVYPTRPSHHVLKGLDIEIKKGETIALVGASGCGKSTTIQLIQRNYEPN 448
Query: 1271 AGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSD---VSDEDIARAL 1441
G++ +D I + NIK+LR +G+V QE LF+ +I +NI G + +S +++
Sbjct: 449 GGRVTLDGKDIRELNIKWLRNQIGLVGQESVLFSGTIRENIMLGAKEGETLSKDEMIECA 508
Query: 1442 KEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAE 1621
K ANA +F+ EG +TL+G++G +SGGQKQRIAIARAL+RNP ILLLDEATSALD +
Sbjct: 509 KVANAYEFVSKLAEGYDTLIGEKGALLSGGQKQRIAIARALIRNPSILLLDEATSALDTQ 568
Query: 1622 SESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHE 1801
SE IVQ ALE AS+GRTTI++AHRL+TVRNAD+I V G+++E G H+ LI+ KG Y+
Sbjct: 569 SEKIVQEALEKASKGRTTIIVAHRLTTVRNADQICVFHQGEIIEQGKHQELIDLKGTYYG 628
Query: 1802 LVHAQVFADVDDKPKKKEAERRMSRQTSQRKGSV-NFKTQESQVDXXXXXXXXXXXXXXX 1978
LV Q ++++ +++ E + + Q V N +ES +
Sbjct: 629 LVKGQ---SMEEEVEQETVENDIKKFRKQEDKEVENIIVEESHDEEEEEDIVSKIKEEYE 685
Query: 1979 XXXXXXXXXXXGAVKANLFKILR----YARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQI 2146
K N F I+R R ++ ++ GAV P F++ F +
Sbjct: 686 KEKKIRK-------KRNRFSIIRIMIEQLRMNFVLFILATIGGIVGGAVFPIFTIKFIDL 738
Query: 2147 INVFSN-------PDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIR 2305
I + D Q +M + A + T +F +AE L +R
Sbjct: 739 IVMMMELQDGVELTDEQQHTLVNTIIWVMGIAFAGLLSTYCYI--GIFASSAEYLIGSVR 796
Query: 2306 SKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGI 2485
++++++++Q+ +FD ++ G + TRL++D + LG I ++++ G
Sbjct: 797 RRMFKSIVKQEIGWFDRKENRVGSLVTRLSSDPTKLNGITGVILGHIVYILSTICFAFGF 856
Query: 2486 AFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQA 2665
A YY W++A V+A+FP + K + ++ K E +G T +EA+E+++TVQ+
Sbjct: 857 ALYYDWKLALCVIAVFPIHTLILFFDFKLNSMQSSPAEKAYEESGITLVEAVESMKTVQS 916
Query: 2666 LTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLI----- 2830
LT + + +L P+ +I L N F A + G +L+
Sbjct: 917 LTREEYFLKQYSLNLKKPYKSIFKWGLILALVNAITNLSNFIVDAYGYYLGTYLLAKNLN 976
Query: 2831 -------FDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEE 2989
F + + + + + ++ F+ +G P+ K+ AA +N+++
Sbjct: 977 YTQTNQGFYQEFMDRYMKIQKAIMSVVFAAHGVGNFGEIIPDIGKSMKAARHSYNLIDRN 1036
Query: 2990 PRIDGMTSSG-TYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCG 3166
+ID +G T+ + GE++ + FRYP R +L+G++ G+T+ALVG SGCG
Sbjct: 1037 AKIDSSEINGNTFNDVKGEIEFKNIRFRYPTRADNEVLKGISFKADQGKTIALVGASGCG 1096
Query: 3167 KSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGL 3346
KST I L+ER YDP G V +D +++ +N K LR I LV QEP+LF S+ +NI G+
Sbjct: 1097 KSTTIQLVERFYDPTSGEVLLDGYNIKDLNVKFLRNQIGLVGQEPVLFAESVIDNIKRGV 1156
Query: 3347 QPG-EYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNP 3523
G E ++EQI A AN H FI +P+GY T VG++G+QLSGGQKQRIAIARALIRNP
Sbjct: 1157 PEGVEVSNEQIYAAAKMANAHDFISAMPEGYNTMVGDRGSQLSGGQKQRIAIARALIRNP 1216
Query: 3524 KILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQ 3703
K+LLLDEATSALDT+SEK VQ ALD A+K RT I++AHRLSTI NA I V+ G++VEQ
Sbjct: 1217 KVLLLDEATSALDTQSEKIVQDALDKASKGRTTIIIAHRLSTIQNADQICVIMRGKIVEQ 1276
Query: 3704 GTHNELIAKRGAYFALTQKQ 3763
GTH EL+ +G Y+ L +Q
Sbjct: 1277 GTHQELMDLKGFYYTLAMQQ 1296
Score = 339 bits (869), Expect = 3e-91
Identities = 213/540 (39%), Positives = 310/540 (56%), Gaps = 10/540 (1%)
Frame = +2
Query: 2186 KDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKH 2365
K+G ++ ++ +VL S L SLF V ++R +R+R ++++LRQDAT++D +
Sbjct: 111 KNGIYYEVISMVL------SFLRTFSLF-VVSQREGIRVRRLYFKSLLRQDATWYDFQES 163
Query: 2366 SPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMA 2545
G +T R+ATD N + I + G IF I+ V G I F W +A +V+A PF +
Sbjct: 164 --GELTARIATDIKNYQDGIGPKFGMIFQIISMVITGCVIEFKKCWDLALVVLATVPFSS 221
Query: 2546 ----VGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHL- 2710
+ Q + MKY T K AG A E I NIRTVQ+L + + + +
Sbjct: 222 FSFTIFQIIGMKYE----TKALKVFGAAGAIAEETIGNIRTVQSLNQKNEFIAEYQEKIK 277
Query: 2711 -DAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVL--MEPENVLRVLF 2881
+ G + ++ + + +YA +G +I K + +VL V
Sbjct: 278 QNEHFNGIKGQCLMSWIRFSVITFFMIASYALGSWYGSLVIRGKGGSKGVFAGHVLTVFL 337
Query: 2882 AISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYP-QLSGEVKLNK 3058
++ + T+ A +A IF ++ P ID + G P + +G ++
Sbjct: 338 SVLSASQTLSMIAILLNLLFSDKASAYKIFTTIDRIPDIDCQSIGGECPTECNGNIRFVD 397
Query: 3059 VFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNN 3238
V F YP RP+ +L+GL++ +K G+T+ALVG SGCGKST I L++R Y+P G VT+D
Sbjct: 398 VQFVYPTRPSHHVLKGLDIEIKKGETIALVGASGCGKSTTIQLIQRNYEPNGGRVTLDGK 457
Query: 3239 DLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSK-ANIHKFI 3415
D+R++N K LR I LV QE +LF +IRENI+ G + GE + C+K AN ++F+
Sbjct: 458 DIRELNIKWLRNQIGLVGQESVLFSGTIRENIMLGAKEGETLSKDEMIECAKVANAYEFV 517
Query: 3416 DELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVAL 3595
+L +GY+T +GEKG LSGGQKQRIAIARALIRNP ILLLDEATSALDT+SEK VQ AL
Sbjct: 518 SKLAEGYDTLIGEKGALLSGGQKQRIAIARALIRNPSILLLDEATSALDTQSEKIVQEAL 577
Query: 3596 DAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSSNQ 3775
+ A+K RT I+VAHRL+T+ NA I V G+++EQG H ELI +G Y+ L + QS +
Sbjct: 578 EKASKGRTTIIVAHRLTTVRNADQICVFHQGEIIEQGKHQELIDLKGTYYGLVKGQSMEE 637
>gi|50556486|ref|XP_505651.1| hypothetical protein [Yarrowia
lipolytica]
gi|49651521|emb|CAG78460.1| unnamed protein product [Yarrowia
lipolytica CLIB99]
Length = 1326
Score = 749 bits (1933), Expect = 0.0
Identities = 454/1257 (36%), Positives = 678/1257 (53%), Gaps = 15/1257 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
++ L+RY + +D +L +G++ + A GV +PL ++I G ++ F+ F+ S+A
Sbjct: 110 VNFLTLFRYATKLDIFILFIGMVTAAAAGVCMPLFTVIFGQMTNEFLA----FIVLGSSA 165
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
F H++ L +VY+ F ++ + E+LS R R + ++MR
Sbjct: 166 DR-------FQHQINHYALYFVYIAVATFCLTSIKTYITVERGERLSARIRENYLKAIMR 218
Query: 401 QEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLI 580
Q I ++DK +G ++N++ + ++EG +K+GL ++ FI + F LT I
Sbjct: 219 QNIGYFDKLGAGEVTNRITTDTNLIQEGISEKLGLIVSAVSSFITSLVIGFIKSARLTGI 278
Query: 581 MMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRY 760
M+S +++ + IAEE SI ++AF Q KRY
Sbjct: 279 MISTVVALVLAMGICSTFLVRYVRWAIEDDSECSSIAEECFASITNIVAFGMQVKMDKRY 338
Query: 761 EDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFS 940
E L K + K+ ++GA + + I Y Y LA W G+ V G G V+TV +
Sbjct: 339 EKPLNSSLKNYLLKARVLGAMVGILWCITYCMYALALWEGSRLVNKGETSIGHVITVLMA 398
Query: 941 VMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKV 1120
+M+G+ LG ++G+A+GA ++E IDR+P+ID+ S G+T S + G IS V
Sbjct: 399 LMIGAFQLGGVAPNMESLGSAVGAGKKIFETIDRVPDIDSLSG-GETLSNLRGAISFKNV 457
Query: 1121 EFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIP 1300
F YP+R V IL+ +LD G TVALVG+SG GKSTI+ LL+RFY P G I +D +
Sbjct: 458 HFRYPSRPTVPILREFNLDIPSGATVALVGASGSGKSTIVALLERFYQPLGGSITVDGVS 517
Query: 1301 IEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALK---------EAN 1453
I ++K+LRQ + +VSQEP LFN +I +NI +G E+ R++K +AN
Sbjct: 518 ILSLDVKWLRQQMSLVSQEPTLFNCTIFENISHGLIGTEYENAERSVKMKLVEDACEQAN 577
Query: 1454 AADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESI 1633
++FIKT +GL+T VG++G +SGGQKQR+AIARA++ NP ILLLDEATSALD SE +
Sbjct: 578 CSEFIKTLTDGLDTQVGEKGYLLSGGQKQRVAIARAIISNPPILLLDEATSALDTRSEKL 637
Query: 1634 VQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHA 1813
VQ AL+ A++ RTTIVIAHRLST++NADKI+VM G+++E G+H+ LI +G Y+ LV A
Sbjct: 638 VQQALDKAAKNRTTIVIAHRLSTIKNADKIVVMSKGEILEQGSHDELIAARGTYYGLVGA 697
Query: 1814 QVFADVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXX 1993
Q D G T E
Sbjct: 698 QRIED---------------------GGPETASTTEKGYYWESGSGSDFDVGSNVSVEKT 736
Query: 1994 XXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPD- 2170
G +K + R+ R E + +I GA P+ +L + ++ F
Sbjct: 737 TPLNTWGMIKL----LARFNRNERLPLLLGSGFAVICGAGYPSLALLYGSVMQAFMVDPL 792
Query: 2171 --RDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDAT 2344
+ + + F F+V VQ S Q GVA+E L ++ ++ ++L QD
Sbjct: 793 AYKHMLHEIDKFSGFFFMV-GMVQLGSYFMQVYYLGVASETLVRNLKRTIFSHLLNQDLR 851
Query: 2345 YFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVM 2524
+FD + G++T+ L+ D N++ G I ++I +V + ++ Y W++ +
Sbjct: 852 FFDTT--TTGKLTSSLSKDTQNVQGLGGATFGQILSSIVTVIISVILSCCYTWKLGLVCS 909
Query: 2525 AIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCS 2704
A P + K E++ A EA NI+TV ALT + + N + S
Sbjct: 910 ACIPLILSSGFFRFYILTQLNQRGRKVYESSAGYACEATNNIQTVMALTREDDVLNFYSS 969
Query: 2705 HLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFA 2884
++ + I + +G + ++ A F +G LI + + +
Sbjct: 970 KVNNVVYHSAKSNAISSMLFGASQTLIILINALGFWYGSTLIRKREI--DINQFFVAFVT 1027
Query: 2885 ISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTY---PQLSGEVKLN 3055
+ F + G S+ P+ KA A I +L+ +P I G SG ++ G + +
Sbjct: 1028 VVFGVQSAGSIFSFTPDMGKAKVATQSIHEILKVKPEIGGDKESGLSLDPEKVVGNISFD 1087
Query: 3056 KVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDN 3235
V FRYPERP +P+LQGL++ + G +ALVG SGCGKST ISL+ER YD L+G++T+D
Sbjct: 1088 NVRFRYPERPKIPVLQGLSLSIPAGSYVALVGSSGCGKSTTISLIERFYDVLQGSITIDG 1147
Query: 3236 NDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFI 3415
D+R +N R I+LV QEPILF +IRENI+ G + G+ + +A +ANIH F+
Sbjct: 1148 IDIRDLNLGSYRSLISLVQQEPILFSGTIRENILLGAE-GDVDDATLHSAAIQANIHNFV 1206
Query: 3416 DELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVAL 3595
LPDGY+T G KGT LSGGQKQR+AIARALIR+PKILLLDEATSALD+ESEK VQ AL
Sbjct: 1207 MSLPDGYDTFCGNKGTLLSGGQKQRVAIARALIRDPKILLLDEATSALDSESEKVVQQAL 1266
Query: 3596 DAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQS 3766
D AA+ RT I VAHRLSTI NA I V+++G+V+EQGTH+ L+AK+G Y+ L + Q+
Sbjct: 1267 DTAAQGRTTIAVAHRLSTIQNADSIYVLEDGKVLEQGTHSHLMAKKGRYYELVKLQA 1323
Score = 347 bits (889), Expect = 2e-93
Identities = 225/605 (37%), Positives = 320/605 (52%), Gaps = 17/605 (2%)
Frame = +2
Query: 2018 VKANLFKILRYARPEWIYXXXXXX-XXLIQGAVMPAFSLFFSQIINVFS-----NPDRDQ 2179
VK N + RYA I+ G MP F++ F Q+ N F D+
Sbjct: 108 VKVNFLTLFRYATKLDIFILFIGMVTAAAAGVCMPLFTVIFGQMTNEFLAFIVLGSSADR 167
Query: 2180 MKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMP 2359
+ + +AL F+ +A + + ERL+ RIR + ++RQ+ YFD
Sbjct: 168 FQHQINHYALYFVYIAVATFCLTSIKTYITVERGERLSARIRENYLKAIMRQNIGYFD-- 225
Query: 2360 KHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFL----VMA 2527
K G +T R+ TD I+ I +LG I +A++S L I F ++ + V+A
Sbjct: 226 KLGAGEVTNRITTDTNLIQEGISEKLGLIVSAVSSFITSLVIGFIKSARLTGIMISTVVA 285
Query: 2528 IFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSH 2707
+ M + +++Y + D++ A E +I + A +Q K+ +
Sbjct: 286 LVLAMGICSTFLVRYVRWAIEDDSE----CSSIAEECFASITNIVAFGMQVKMDKRYEKP 341
Query: 2708 LDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAI 2887
L++ + KA + G G I + YA A G L+ + +V+ VL A+
Sbjct: 342 LNSSLKNYLLKARVLGAMVGILWCITYCMYALALWEGSRLVNKGETSIG--HVITVLMAL 399
Query: 2888 SFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVFF 3067
+G A A A IF ++ P ID ++ T L G + V F
Sbjct: 400 MIGAFQLGGVAPNMESLGSAVGAGKKIFETIDRVPDIDSLSGGETLSNLRGAISFKNVHF 459
Query: 3068 RYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLR 3247
RYP RP VPIL+ N+ + G T+ALVG SG GKST+++LLER Y PL G++TVD +
Sbjct: 460 RYPSRPTVPILREFNLDIPSGATVALVGASGSGKSTIVALLERFYQPLGGSITVDGVSIL 519
Query: 3248 QMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQ-------IETACSKANIH 3406
++ K LR+ ++LVSQEP LF+ +I ENI +GL EY + + +E AC +AN
Sbjct: 520 SLDVKWLRQQMSLVSQEPTLFNCTIFENISHGLIGTEYENAERSVKMKLVEDACEQANCS 579
Query: 3407 KFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQ 3586
+FI L DG +T+VGEKG LSGGQKQR+AIARA+I NP ILLLDEATSALDT SEK VQ
Sbjct: 580 EFIKTLTDGLDTQVGEKGYLLSGGQKQRVAIARAIISNPPILLLDEATSALDTRSEKLVQ 639
Query: 3587 VALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQS 3766
ALD AAK+RT IV+AHRLSTI NA I+V+ G+++EQG+H+ELIA RG Y+ L Q
Sbjct: 640 QALDKAAKNRTTIVIAHRLSTIKNADKIVVMSKGEILEQGSHDELIAARGTYYGLVGAQR 699
Query: 3767 SNQSG 3781
G
Sbjct: 700 IEDGG 704
>gi|15217809|ref|NP_174122.1| multidrug resistance P-glycoprotein,
putative [Arabidopsis thaliana]
gi|25297457|pir||F86405 probable P-glycoprotein [imported] -
Arabidopsis thaliana
gi|12322986|gb|AAG51476.1| P-glycoprotein, putative [Arabidopsis
thaliana]
Length = 1247
Score = 748 bits (1932), Expect = 0.0
Identities = 454/1258 (36%), Positives = 685/1258 (54%), Gaps = 15/1258 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+S+ L+ VD ++ +G + +C G LPL + G + + LG + DPN+ +
Sbjct: 31 VSLMGLFSAADNVDYFLMFLGGLGTCIHGGTLPLFFVFFGGMLDS---LGKLSTDPNAIS 87
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
S V QN L VYLG + ++ +C+M E+ + R R + S++
Sbjct: 88 SR-----------VSQNALYLVYLGLVNLVSAWIGVACWMQTGERQTARLRINYLKSILA 136
Query: 401 QEIAWYDKNTSGTLSNKLF---DNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLL 571
++I ++D T SN +F + V++ GDK G + + QFI GF + F W L
Sbjct: 137 KDITFFD--TEARDSNFIFHISSDAILVQDAIGDKTGHVLRYLCQFIAGFVIGFLSVWQL 194
Query: 572 TLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYEC 751
TL+ + + P + I G YA AG +AEEV++ +RTV AF G+E
Sbjct: 195 TLLTLGVVPLIAIAGGGYAIVMSTISEKSEAAYADAGKVAEEVMSQVRTVYAFVGEEKAV 254
Query: 752 KRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTV 931
K Y ++L+ K + G G+ + +++ ++ L FW + V G+ T
Sbjct: 255 KSYSNSLKKALKLSKRSGLAKGLGVGLTYSLLFCAWALLFWYASLLVRHGKTNGAKAFTT 314
Query: 932 FFSVMMGSMALGQAGQQFATIGTALGAAASLYEVI-DRIPEIDAYSTEGQTPSKISGRIS 1108
+V+ ALGQA + I AAA+++++I + E G T + G+I
Sbjct: 315 ILNVIYSGFALGQAVPSLSAISKGRVAAANIFKMIGNNNLESSERLENGTTLQNVVGKIE 374
Query: 1109 VNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILI 1288
V F YP+R ++ + + +S G+T A VG SG GKSTII ++QRFY P +G+IL+
Sbjct: 375 FCGVSFAYPSRPNM-VFENLSFTIHSGKTFAFVGPSGSGKSTIISMVQRFYEPRSGEILL 433
Query: 1289 DDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFI 1468
D I++ +K+LR+ +G+VSQEP LF T+I NI G+ + + I A K ANA FI
Sbjct: 434 DGNDIKNLKLKWLREQMGLVSQEPALFATTIASNILLGKEKANMDQIIEAAKAANADSFI 493
Query: 1469 KTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSAL 1648
K+ P G NT VG+ G Q+SGGQKQRIAIARA++RNPKILLLDEATSALDAESE IVQ AL
Sbjct: 494 KSLPNGYNTQVGEGGTQLSGGQKQRIAIARAVLRNPKILLLDEATSALDAESEKIVQQAL 553
Query: 1649 ENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFAD 1828
+N RTTIVIAHRLST+RN DKI+V++ GQV E G+H LI + G Y LV+ Q
Sbjct: 554 DNVMEKRTTIVIAHRLSTIRNVDKIVVLRDGQVRETGSHSELISRGGDYATLVNCQ---- 609
Query: 1829 VDDKPKKK------EAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXX 1990
D +P++ E+ R + S R+ + +T + D
Sbjct: 610 -DTEPQENLRSVMYESCRSQAGSYSSRRVFSSRRTSSFREDQEKTEKDSKGEDLISS--- 665
Query: 1991 XXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPD 2170
+ ++++++ PEW+Y ++ G+ FS+ + ++ F +P
Sbjct: 666 ----------SSMIWELIKLNAPEWLYALLGSIGAVLAGSQPALFSMGLAYVLTTFYSPF 715
Query: 2171 RDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYF 2350
+K++ A++F+ V + Q + + ERLT R+R ++ +L + +F
Sbjct: 716 PSLIKREVDKVAIIFVGAGIVTAPIYILQHYFYTLMGERLTSRVRLSLFSAILSNEIGWF 775
Query: 2351 DMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAI 2530
D+ +++ G +T+ LA DA ++SAI RL +I ++ L +AF+Y W++A +V A
Sbjct: 776 DLDENNTGSLTSILAADATLVRSAIADRLSTIVQNLSLTITALALAFFYSWRVAAVVTAC 835
Query: 2531 FPFM---AVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFC 2701
FP + ++ + L +K GG T + A A EAI NIRTV A + + ++ F
Sbjct: 836 FPLLIAASLTEQLFLKGFGGDYT---RAYSRATSLAREAISNIRTVAAFSAEKQISEQFT 892
Query: 2702 SHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLF 2881
L P + + I G YG + + F +YA + LI K E+ ++
Sbjct: 893 CELSKPTKSALLRGHISGFGYGLSQCLAFCSYALGLWYISVLI--KRNETNFEDSIKSFM 950
Query: 2882 AISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRI-DGMTSSGTYPQLSGEVKLNK 3058
+ + ++ + P+ +K T A G +F +L E I +S + G+++
Sbjct: 951 VLLVTAYSVAETLALTPDIVKGTQALGSVFRVLHRETEIPPDQPNSRLVTHIKGDIEFRN 1010
Query: 3059 VFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNN 3238
V F YP RP + I + LN+ V G++LA+VGPSG GKSTVI L+ R YDP G + +D +
Sbjct: 1011 VSFAYPTRPEIAIFKNLNLRVSAGKSLAVVGPSGSGKSTVIGLIMRFYDPSNGNLCIDGH 1070
Query: 3239 DLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFID 3418
D++ +N + LRK +ALV QEP LF TSI ENI YG + + +I A AN H+FI
Sbjct: 1071 DIKSVNLRSLRKKLALVQQEPALFSTSIHENIKYGNE--NASEAEIIEAAKAANAHEFIS 1128
Query: 3419 ELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALD 3598
+ +GY T VG+KG QLSGGQKQR+AIARA++++P +LLLDEATSALDT +EKQVQ ALD
Sbjct: 1129 RMEEGYMTHVGDKGVQLSGGQKQRVAIARAVLKDPSVLLLDEATSALDTSAEKQVQEALD 1188
Query: 3599 AAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKR-GAYFALTQKQSS 3769
K RT I+VAHRLSTI A I+V+ G+VVE+G+H EL++K G Y LT Q +
Sbjct: 1189 KLMKGRTTILVAHRLSTIRKADTIVVLHKGKVVEKGSHRELVSKSDGFYKKLTSLQEA 1246
>gi|27368847|emb|CAD59581.1| MDR-like ABC transporter [Oryza sativa
(japonica cultivar-group)]
Length = 1256
Score = 747 bits (1929), Expect = 0.0
Identities = 434/1249 (34%), Positives = 667/1249 (52%), Gaps = 8/1249 (0%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
++ +L+ + +D L++A G + G +P+ ++ G + F
Sbjct: 29 VAFHELFGFADPLDWLLMAAGSAGAVVHGAAMPVFFLLFGELINGF----------GKNQ 78
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
E+S L +VYLG + A+ +L+ +C+M E+ RR++ +V+R
Sbjct: 79 HSLRRMTDEYS-------LYFVYLGLVVCASSYLEIACWMYTGERQVGALRRRYLEAVLR 131
Query: 401 QEIAWYDKNT-SGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
Q++ ++D + +G + + + V++ G+KVG ++ F+ G V F W L L
Sbjct: 132 QDVGFFDTDARTGDVVFSVSTDTLLVQDAIGEKVGNFIHYLSTFLAGLVVGFVSAWRLAL 191
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
+ +++ P + G YA AG IAE+ + +RTV ++ G+
Sbjct: 192 LSIAVIPGIAFAGGLYAYTLTGLTSKSRDSYANAGIIAEQAIAQVRTVYSYVGESKALNS 251
Query: 758 YEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFF 937
Y +A+++ K G K G G+ + I S+ L FW F+ +G+ + G T F
Sbjct: 252 YSEAIQNTLKLGYKAGMAKGLGIGCTYGIACMSWALVFWYAGVFIRNGQTDGGKAFTAIF 311
Query: 938 SVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNK 1117
S ++G ++LGQ+ A L EVI + P I +G+ ++ G I +
Sbjct: 312 SAIVGGLSLGQSFSNLGAFSKGKIAGYKLLEVIRQRPTIVQDPADGRCLDEVHGNIEFKE 371
Query: 1118 VEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDI 1297
V F+YP+R DV I + SL G+T A+VG SG GKST++ L++RFY+P+ GQ+L+D++
Sbjct: 372 VAFSYPSRPDVMIFRDFSLFFPAGKTAAVVGGSGSGKSTVVALIERFYDPNQGQVLLDNV 431
Query: 1298 PIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTF 1477
I+ +K+LR +G+V+QEP LF T+I +NI YG+ D + ++ A ANA FI
Sbjct: 432 DIKTLQLKWLRDQIGLVNQEPALFATTILENILYGKPDATMAEVEAAATSANAHSFIALL 491
Query: 1478 PEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENA 1657
P G NT VG+RG+Q+SGGQKQRIAIARA+++NPKILLLDEATSALDA SE+IVQ AL+
Sbjct: 492 PNGYNTQVGERGLQLSGGQKQRIAIARAMLKNPKILLLDEATSALDAGSENIVQEALDRL 551
Query: 1658 SRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQ--KGLYHELVHAQVFA-- 1825
GRTT+V+AHRLST+R D I V++ GQV+E GTH+ L+ + G Y L+ Q A
Sbjct: 552 MVGRTTVVVAHRLSTIRCVDMIAVIQQGQVVETGTHDELLAKGSSGAYAALIRFQEMARN 611
Query: 1826 -DVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXX 2002
D +K R+S S R S+ + +
Sbjct: 612 RDFRGPSTRKSRSSRLSNSLSTRSLSL----RSGSLRNLSYSYSTGADGRIEMVSNADND 667
Query: 2003 XXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQM 2182
A K FK+L+ PEW Y ++ G + P F++ S +I VF D + M
Sbjct: 668 RKYPAPKGYFFKLLKLNAPEWPYTILGAIGSILSGFIGPTFAIVMSNMIEVFYFRDPNAM 727
Query: 2183 KKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPK 2362
++ + +++ + L Q F + E LT R+R + +LR D +FD +
Sbjct: 728 ERKTREYVFIYIGTGLYAVVAYLVQHYFFSIMGENLTTRVRRMMLAAILRNDVGWFDQEE 787
Query: 2363 HSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFM 2542
++ + RL+TDA ++KSAI R+ I + S+ + F W++A L++ FP +
Sbjct: 788 NNSSLVAARLSTDAADVKSAIAERISVILQNMTSLLVSFVVGFIIEWRVAVLILVTFPLL 847
Query: 2543 AVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPH 2722
+ G A AK A E + NIRTV A Q K+ ++FC+ L P
Sbjct: 848 VLANFAQQLSMKGFAGDTAKAHAKTSMIAGEGVSNIRTVAAFNAQDKVLSLFCTELRVPQ 907
Query: 2723 GGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFG 2902
++ ++ I G +G + + + A +G L+ ++ + V++V + +
Sbjct: 908 MHSLRRSQISGALFGLSQLSLYASEALILWYGAHLV--RHHVSTFSKVIKVFVVLVITAN 965
Query: 2903 TIGFAASYFPEYIKATFAAGLIFNMLEEEPRID-GMTSSGTYPQLSGEVKLNKVFFRYPE 3079
T+ S PE ++ + +F +L RID + + G++ V F YP
Sbjct: 966 TVAETVSLAPEIVRGGESIRSVFAILNYRTRIDPDEPETEPVESVRGDIDFRHVDFAYPS 1025
Query: 3080 RPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNP 3259
RP V + + ++ ++ GQ+ ALVG SG GKSTVI+L+ER YDPL G V +D D+R++N
Sbjct: 1026 RPDVMVFKDFSLRIRAGQSQALVGASGSGKSTVIALIERFYDPLAGKVMIDGKDIRRLNV 1085
Query: 3260 KHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYE 3439
+ LR I LV QEP+LF TSI ENI YG T E++ A AN+H F+ LP+GY+
Sbjct: 1086 RSLRLKIGLVQQEPVLFATSIFENIAYGKDGA--TEEEVIEAAKVANMHGFVSALPEGYK 1143
Query: 3440 TRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRT 3619
T VGE+G QLSGGQKQRIAIARA++++P +LLLDEATSALD ESE +Q AL+ K RT
Sbjct: 1144 TPVGERGVQLSGGQKQRIAIARAVLKDPAVLLLDEATSALDAESECVLQEALERIMKGRT 1203
Query: 3620 CIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAK-RGAYFALTQKQ 3763
++VAHRLSTI I VV++G+VVEQG+H EL+++ GAY L Q Q
Sbjct: 1204 AVLVAHRLSTIRGVDSIAVVQDGRVVEQGSHGELVSRPDGAYSRLLQLQ 1252
>gi|39594943|emb|CAE70811.1| Hypothetical protein CBG17574
[Caenorhabditis briggsae]
Length = 1628
Score = 745 bits (1924), Expect = 0.0
Identities = 424/1022 (41%), Positives = 612/1022 (59%), Gaps = 8/1022 (0%)
Frame = +2
Query: 668 YAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVII 847
YA AGGIA + L+ +TVI+ NGQ YE K Y L+ G+K GI ++ L A
Sbjct: 12 YANAGGIAYQALSCFKTVISLNGQSYELKSYSSELKLGEKHGIHRALLFATSRAVTNFFC 71
Query: 848 YASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLY 1027
A ++G +Y+ ++ +++T+F +M+ + +L + + + A+ +A+S++
Sbjct: 72 SALNGTLLYIGAGLIYNKTMDQASIVTLFHYMMLSAYSLAEVLPHISNLLNAISSASSIF 131
Query: 1028 EVI----DRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQT 1195
E++ D I D + Q P I+G I V F+YPTR + K+LKG+SL+ + G+
Sbjct: 132 EILTSNDDNIENEDV--PDDQKP--INGVIQFKDVRFSYPTRPNAKVLKGISLEVKRGEC 187
Query: 1196 VALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNT 1375
VALVG+SG GKST++QLL R YN D+G I ID + +E+ ++K LR+ +GVVSQEP LF+T
Sbjct: 188 VALVGASGSGKSTLVQLLLRHYNKDSGSISIDGVELENISLKKLRRNIGVVSQEPILFDT 247
Query: 1376 SIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIA 1555
+IEQNIR+G + S +I ALK+ANA +F+ +FP G+ T+VG+ G Q+SGGQKQRIAIA
Sbjct: 248 TIEQNIRFGNPECSKFEIFDALKKANAYEFVASFPNGIETIVGEGGAQLSGGQKQRIAIA 307
Query: 1556 RALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMK 1735
R LV+NPKILLLDEATSALD ESE +Q AL AS GRTTI+IAHRLST+ N DKIIVM
Sbjct: 308 RVLVKNPKILLLDEATSALDNESEREIQKALRKASEGRTTIIIAHRLSTINNCDKIIVMS 367
Query: 1736 AGQVMEVGTHETLIEQKGLYHELVHAQVFADVDDKPKKKEA---ERRMSRQTSQRKGSVN 1906
GQ++E G H+ LI++ G Y+ L+++Q+F + + +K+ + S RK S
Sbjct: 368 QGQIIESGAHKHLIQKAGAYNNLINSQIFDSEEKQTSQKDPLDINKIKENSNSLRKSSKG 427
Query: 1907 FKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXX 2086
+Q S D V + ++I+ RP++ +
Sbjct: 428 --SQASLTDTPEEKE----------------------VSSGFWEIINECRPQYFWLLTAI 463
Query: 2087 XXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSL 2266
+QG P + + +S D + GHFWA MF L ++ +
Sbjct: 464 IGSFMQGLSPPLLAQLIVRTYKAYSMEGEDILIY-GHFWASMFFALGLIRPITAYTTHYC 522
Query: 2267 FGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSI 2446
+G AE+L+ R+R K + ++L ++D K+SP R+ RL TDA N+K A+D RLG+I
Sbjct: 523 YGRVAEKLSTRLRIKSFHHMLSLPCAFYDESKNSPTRLANRLNTDASNVKGAVDSRLGTI 582
Query: 2447 FNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKT 2626
F + S + +A YY W++ ++ FP + G+ S D+ +E + K
Sbjct: 583 FTTLVSFLVSISVASYYSWKLTIQIILFFPILYFGKRCYDNATVQSVKQDSALIEKSNKI 642
Query: 2627 AMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAA 2806
A+E + NI+TV++L + K+ ++ L+ KAI GL GF+ +F YAA+
Sbjct: 643 AVEVLNNIKTVRSLNMGDKVMSMIIGELEVLRKKYRWKAITLGLANGFSVICHYFFYAAS 702
Query: 2807 FRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEE 2986
F+FG LI + +L P N+ +S++ +G Y PEY KA AAGLIFN+L+
Sbjct: 703 FKFGTHLILQREIL--PMNMYVSFITLSYTSNMVGNVMLYLPEYRKAVHAAGLIFNLLKT 760
Query: 2987 EPRIDGMTSSGTYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCG 3166
+ + G+ +G VK + + F Y +R +L+ +N+ +KPG+TLALVGPSG G
Sbjct: 761 PATMPYDSKEGSMEIKNGVVKGSNISFHYHQRLDHMVLKNVNLSLKPGKTLALVGPSGSG 820
Query: 3167 KSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGL 3346
KS+ ISL+ER Y G V +DN D+ +N HLR ++ LV+QEP+LF+ SIR+N++YGL
Sbjct: 821 KSSFISLIERFYQVDTGCVKIDNEDVEDINIHHLRSNLGLVAQEPVLFNCSIRQNLLYGL 880
Query: 3347 QPGEYTHE-QIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNP 3523
+ E E +IE A AN FI + P+G T VGE G QLSGGQKQRIAIARA++RNP
Sbjct: 881 E--ELVEEIKIEKALRTANALDFIQKFPEGLNTIVGEHGAQLSGGQKQRIAIARAILRNP 938
Query: 3524 KILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQ 3703
KILLLDEATSALD++SEK VQ ALD A + + +VVAHRLSTIVNA I V +NGQVVEQ
Sbjct: 939 KILLLDEATSALDSDSEKLVQNALDTAIERLSTVVVAHRLSTIVNADSIAVFENGQVVEQ 998
Query: 3704 GT 3709
G+
Sbjct: 999 GS 1000
Score = 341 bits (875), Expect = 7e-92
Identities = 204/590 (34%), Positives = 316/590 (52%), Gaps = 3/590 (0%)
Frame = +2
Query: 1385 QNIRYGRSDVSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARAL 1564
+NI +G + + +I AL++ANA DF+ +FP+G+ ++VG+RG Q+SGGQKQRIAIAR L
Sbjct: 1049 ENILFGNPNATVSEIYEALRKANAYDFVNSFPKGIKSVVGERGAQLSGGQKQRIAIARTL 1108
Query: 1565 VRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQ 1744
VRNPKILLL EATSALD ESE +VQ ALE AS GRTTIVIAHRLST+RNA KIIVM G+
Sbjct: 1109 VRNPKILLL-EATSALDNESEHVVQRALEKASEGRTTIVIAHRLSTIRNASKIIVMDKGE 1167
Query: 1745 VMEVGTHETLIEQKGLYHELVHAQVFADVDDKPKKKEAERRMSRQTSQRKGSVNFKTQES 1924
+++VG + L H+ + E Q + K +N T+E
Sbjct: 1168 IVKVG------------NVLDHSSQELSARQDSSRTEFSETNEAQDDEIKRLMNELTEE- 1214
Query: 1925 QVDXXXXXXXXXXXXXXXXXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQ 2104
GA K+NL +I++ +P++ +Q
Sbjct: 1215 -----------------------------GAQKSNLREIIKMCKPDYCLFLTALAGSALQ 1245
Query: 2105 GAVMPAFSLFFSQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAE 2284
G + F+ D M GHFWA L+LA + ++ Q G +E
Sbjct: 1246 GLSYQISVKLTVRAYEAFAMNGEDIMIY-GHFWAFAILLLALFRPITLRCQYYYLGKVSE 1304
Query: 2285 RLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIAS 2464
RL+ R+R K +++++ +++D PKHS R++ RL TDA N+K+++D RLGS+F +
Sbjct: 1305 RLSTRLRMKSFKHLMSLPCSFYDDPKHSAIRLSNRLNTDASNVKASVDDRLGSVFMTFVA 1364
Query: 2465 VGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIE 2644
+ + + Y W+M V+ + P + + + + G+ D EN+ + A+EAIE
Sbjct: 1365 ISIAISTSTVYSWKMTIQVLLLCPILYLAEYCYERAIDGAIEKDTLAFENSNRAAIEAIE 1424
Query: 2645 NIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLF 2824
+IRTV+AL ++ ++ ++ HL H +A+I+G GF F+ Y+ +F+FG +
Sbjct: 1425 HIRTVRALNMEDRIMDMVADHLQKSHNSCFKRAVIQGAANGFFCCCFFYIYSISFKFGTW 1484
Query: 2825 LIFDKNVLMEPENVLRVLFAISFSFG---TIGFAASYFPEYIKATFAAGLIFNMLEEEPR 2995
L K ++ ++ + ++ ++ G A +Y P+Y KA AAGLIF++
Sbjct: 1485 LAMHKEIMPMETYMVSMTLTLTSTYDLWLMAGSAVAYLPDYKKAAHAAGLIFHLFTYPET 1544
Query: 2996 IDGMTSSGTYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLAL 3145
+ + GT G+V + F Y +RP IL G+N+ V+PG+TLAL
Sbjct: 1545 MAYGSKDGTKNIKLGKVVGENLKFHYEQRPDKTILDGVNLRVEPGKTLAL 1594
Score = 303 bits (777), Expect = 2e-80
Identities = 186/482 (38%), Positives = 273/482 (56%), Gaps = 5/482 (1%)
Frame = +2
Query: 332 CFMVICEKLSNRFRRQFFHSVMRQEIAWYD--KNTSGTLSNKLFDNLERVREGTGDKVGL 505
C+ + EKLS R R + FH ++ A+YD KN+ L+N+L + V+ ++G
Sbjct: 522 CYGRVAEKLSTRLRIKSFHHMLSLPCAFYDESKNSPTRLANRLNTDASNVKGAVDSRLGT 581
Query: 506 AFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGG 685
F + F+ +VA Y W LT+ ++ P + +
Sbjct: 582 IFTTLVSFLVSISVASYYSWKLTIQIILFFPILYFGKRCYDNATVQSVKQDSALIEKSNK 641
Query: 686 IAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVII--YASY 859
IA EVL +I+TV + N + LE +K K+ +G LA+ F +I Y Y
Sbjct: 642 IAVEVLNNIKTVRSLNMGDKVMSMIIGELEVLRKKYRWKAITLG--LANGFSVICHYFFY 699
Query: 860 CLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVID 1039
+F GT+ + + + F ++ S +G A+ AA ++ ++
Sbjct: 700 AASFKFGTHLILQREILPMNMYVSFITLSYTSNMVGNVMLYLPEYRKAVHAAGLIFNLLK 759
Query: 1040 RIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSG 1219
+ S EG K +G + + + F Y R D +LK V+L +PG+T+ALVG SG
Sbjct: 760 TPATMPYDSKEGSMEIK-NGVVKGSNISFHYHQRLDHMVLKNVNLSLKPGKTLALVGPSG 818
Query: 1220 CGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRY 1399
GKS+ I L++RFY D G + ID+ +ED NI +LR +G+V+QEP LFN SI QN+ Y
Sbjct: 819 SGKSSFISLIERFYQVDTGCVKIDNEDVEDINIHHLRSNLGLVAQEPVLFNCSIRQNLLY 878
Query: 1400 GRSDVSDE-DIARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNP 1576
G ++ +E I +AL+ ANA DFI+ FPEGLNT+VG+ G Q+SGGQKQRIAIARA++RNP
Sbjct: 879 GLEELVEEIKIEKALRTANALDFIQKFPEGLNTIVGEHGAQLSGGQKQRIAIARAILRNP 938
Query: 1577 KILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEV 1756
KILLLDEATSALD++SE +VQ+AL+ A +T+V+AHRLST+ NAD I V + GQV+E
Sbjct: 939 KILLLDEATSALDSDSEKLVQNALDTAIERLSTVVVAHRLSTIVNADSIAVFENGQVVEQ 998
Query: 1757 GT 1762
G+
Sbjct: 999 GS 1000
Score = 257 bits (656), Expect = 2e-66
Identities = 152/396 (38%), Positives = 228/396 (57%), Gaps = 1/396 (0%)
Frame = +2
Query: 2579 GSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGL 2758
G++ + + NAG A +A+ +TV +L Q+ + S L I +A++
Sbjct: 3 GASKAQSYHYANAGGIAYQALSCFKTVISLNGQSYELKSYSSELKLGEKHGIHRALLFAT 62
Query: 2759 TYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEY 2938
+ N G LI++K M+ +++ + + S ++ +
Sbjct: 63 SRAVTNFFCSALNGTLLYIGAGLIYNKT--MDQASIVTLFHYMMLSAYSLAEVLPHISNL 120
Query: 2939 IKATFAAGLIFNML-EEEPRIDGMTSSGTYPQLSGEVKLNKVFFRYPERPAVPILQGLNV 3115
+ A +A IF +L + I+ ++G ++ V F YP RP +L+G+++
Sbjct: 121 LNAISSASSIFEILTSNDDNIENEDVPDDQKPINGVIQFKDVRFSYPTRPNAKVLKGISL 180
Query: 3116 HVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQ 3295
VK G+ +ALVG SG GKST++ LL R Y+ G++++D +L ++ K LR++I +VSQ
Sbjct: 181 EVKRGECVALVGASGSGKSTLVQLLLRHYNKDSGSISIDGVELENISLKKLRRNIGVVSQ 240
Query: 3296 EPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSG 3475
EPILFDT+I +NI +G E + +I A KAN ++F+ P+G ET VGE G QLSG
Sbjct: 241 EPILFDTTIEQNIRFGNP--ECSKFEIFDALKKANAYEFVASFPNGIETIVGEGGAQLSG 298
Query: 3476 GQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIV 3655
GQKQRIAIAR L++NPKILLLDEATSALD ESE+++Q AL A++ RT I++AHRLSTI
Sbjct: 299 GQKQRIAIARVLVKNPKILLLDEATSALDNESEREIQKALRKASEGRTTIIIAHRLSTIN 358
Query: 3656 NAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQ 3763
N I+V+ GQ++E G H LI K GAY L Q
Sbjct: 359 NCDKIIVMSQGQIIESGAHKHLIQKAGAYNNLINSQ 394
Score = 128 bits (322), Expect = 9e-28
Identities = 74/127 (58%), Positives = 93/127 (72%)
Frame = +2
Query: 3326 ENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIAR 3505
ENI++G P T +I A KAN + F++ P G ++ VGE+G QLSGGQKQRIAIAR
Sbjct: 1049 ENILFG-NPNA-TVSEIYEALRKANAYDFVNSFPKGIKSVVGERGAQLSGGQKQRIAIAR 1106
Query: 3506 ALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKN 3685
L+RNPKILLL EATSALD ESE VQ AL+ A++ RT IV+AHRLSTI NA I+V+
Sbjct: 1107 TLVRNPKILLL-EATSALDNESEHVVQRALEKASEGRTTIVIAHRLSTIRNASKIIVMDK 1165
Query: 3686 GQVVEQG 3706
G++V+ G
Sbjct: 1166 GEIVKVG 1172
Score = 84.3 bits (207), Expect = 2e-14
Identities = 68/294 (23%), Positives = 122/294 (41%), Gaps = 7/294 (2%)
Frame = +2
Query: 344 ICEKLSNRFRRQFFHSVMRQEIAWYD--KNTSGTLSNKLFDNLERVREGTGDKVGLAFQM 517
+ E+LS R R + F +M ++YD K+++ LSN+L + V+ D++G F
Sbjct: 1302 VSERLSTRLRMKSFKHLMSLPCSFYDDPKHSAIRLSNRLNTDASNVKASVDDRLGSVFMT 1361
Query: 518 MAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEE 697
+ + Y W +T+ ++ L P + + + + A E
Sbjct: 1362 FVAISIAISTSTVYSWKMTIQVLLLCPILYLAEYCYERAIDGAIEKDTLAFENSNRAAIE 1421
Query: 698 VLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWV 877
+ IRTV A N ++ D L+ + K++ + GA F + Y ++F
Sbjct: 1422 AIEHIRTVRALNMEDRIMDMVADHLQKSHNSCFKRAVIQGAANGFFCCCFFYIYSISFKF 1481
Query: 878 GTNFVYSGRLESGTVLTVFFSVMMGS-----MALGQAGQQFATIGTALGAAASLYEVIDR 1042
GT + V ++ + S + G A A AA ++ +
Sbjct: 1482 GTWLAMHKEIMPMETYMVSMTLTLTSTYDLWLMAGSAVAYLPDYKKAAHAAGLIFHLF-T 1540
Query: 1043 IPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVAL 1204
PE AY ++ T + G++ ++F Y R D IL GV+L +PG+T+AL
Sbjct: 1541 YPETMAYGSKDGTKNIKLGKVVGENLKFHYEQRPDKTILDGVNLRVEPGKTLAL 1594
Score = 37.7 bits (86), Expect = 2.2
Identities = 17/48 (35%), Positives = 28/48 (57%)
Frame = +2
Query: 665 QYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSF 808
Q G IA + L + +TV + GQ+ E RY + L+ G++ G +K+F
Sbjct: 994 QVVEQGSIAFQALGAFKTVCSLTGQQQEVHRYSEELKAGERYGFRKAF 1041
>gi|27368849|emb|CAD59582.1| MDR-like ABC transporter [Oryza sativa
(japonica cultivar-group)]
gi|38344910|emb|CAD41854.2| OSJNBb0079B02.13 [Oryza sativa (japonica
cultivar-group)]
gi|38347317|emb|CAE05967.2| OSJNBa0063C18.8 [Oryza sativa (japonica
cultivar-group)]
Length = 1268
Score = 745 bits (1924), Expect = 0.0
Identities = 427/1246 (34%), Positives = 666/1246 (53%), Gaps = 5/1246 (0%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
++ +L+ + D +++A G + + A G +PL ++ G++ F
Sbjct: 39 VAFHELFTFADKWDLVLMAAGSLGALAHGAAMPLFFLLFGDLINGF-------------- 84
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
+ + EV + L +VYLG + A+ + + +C+M E+ R+ + +V+R
Sbjct: 85 GKNQTDLRTMTDEVSKYALYFVYLGLVVCASSYAEIACWMYTGERQVIALRKAYLDAVLR 144
Query: 401 QEIAWYDKNT-SGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
Q++ ++D + +G + + + V++ G+KVG +A F+ G V F W L L
Sbjct: 145 QDVGFFDTDARTGDIVFGVSTDTLLVQDAIGEKVGNFIHYIATFLAGLVVGFVAAWRLAL 204
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
+ +++ P + G YA AG +AE+ + +RTV +F G+
Sbjct: 205 LSVAVIPAIAFAGGLYAYTLTGLTSKSRESYANAGVVAEQAIAQVRTVYSFAGESKALNS 264
Query: 758 YEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFF 937
Y +A+++ K G K G G+ + I S+ L FW F+ +G+ + G T F
Sbjct: 265 YSEAIQNTLKLGYKAGMAKGLGIGCTYGIACMSWALVFWYAGVFIRNGQTDGGKAFTAIF 324
Query: 938 SVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNK 1117
S ++G M+LGQA A L EVI + P I +G+ +++ G I
Sbjct: 325 SAIVGGMSLGQAFSNLGAFSKGKIAGYKLLEVIRQKPSIVHDHKDGKLLAEVHGNIEFKD 384
Query: 1118 VEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDI 1297
V F+YP+R DV I + SL +TVA+VG SG GKST++ L++RFY+P+ GQ+L+D++
Sbjct: 385 VTFSYPSRPDVMIFRDFSLFFPAAKTVAVVGGSGSGKSTVVALIERFYDPNEGQVLLDNV 444
Query: 1298 PIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTF 1477
I+ +++LR +G+V+QEP LF T+I +NI YG+ D + ++ A +NA FI T
Sbjct: 445 DIKTLQLRWLRDQIGLVNQEPALFATTIHENILYGKPDATMAEVEAAATASNAHSFISTL 504
Query: 1478 PEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENA 1657
P G NT+VG+RG+Q+SGGQKQRIAIARA+++NPKILLLDEATSALDA SE+IVQ AL+
Sbjct: 505 PNGYNTMVGERGIQLSGGQKQRIAIARAMLKNPKILLLDEATSALDAGSENIVQEALDRL 564
Query: 1658 SRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQ--KGLYHELVHAQVFADV 1831
GRTT+V+AHRLST+RN + I V++ GQV+E GTH+ L+ + G Y L+ Q A
Sbjct: 565 MTGRTTVVVAHRLSTIRNVNMIAVIQQGQVVETGTHDELLAKGSSGAYASLIRFQEMAQN 624
Query: 1832 DDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXX 2011
D R TS + + + +
Sbjct: 625 RDLGGASTRRSRSMHLTSS-LSTKSLSLRSGSLRNLSYQYSTGANGRIEMISNADNDRKY 683
Query: 2012 GAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKD 2191
A + FK+L+ PEW Y ++ G + P F++ ++++VF D ++M+K
Sbjct: 684 PAPRGYFFKLLKLNAPEWPYAVLGAVGSVLSGFIGPTFAIVMGEMLDVFYYRDPNEMEKK 743
Query: 2192 GHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSP 2371
+ +++ + L Q F + E LT R+R + +L + +FD +++
Sbjct: 744 TKLYVFIYIGTGLYAVVAYLVQHYFFSIMGENLTTRVRRMMLSAILTNEVGWFDEEENNS 803
Query: 2372 GRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVG 2551
+ RLA DA ++KSAI R+ I + S+ + F W++A L++A FP + +
Sbjct: 804 SLVAARLAVDAADVKSAIAERISVILQNMTSLMTSFIVGFIIEWRVALLILATFPLLVLA 863
Query: 2552 QALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGN 2731
G A AK + A E + NIRTV A Q K+ ++F L P
Sbjct: 864 NFAQQLSMKGFAGDTAKAHAKSSMVAGEGVSNIRTVAAFNAQNKILSLFSYELRIPEQQI 923
Query: 2732 ISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIG 2911
+ ++ GL +G + + + A +G L+ V++V + + ++
Sbjct: 924 LRRSQTSGLLFGLSQLCLYSSEALILWYGSHLVRSHGSTF--SKVIKVFVVLVVTANSVA 981
Query: 2912 FAASYFPEYIKATFAAGLIFNMLEEEPRID-GMTSSGTYPQLSGEVKLNKVFFRYPERPA 3088
S PE ++ + IF +L RI+ S + G+++L V F YP RP
Sbjct: 982 ETVSLAPEIVRGGESIRSIFGILNRATRIEPDDPESERVTNVRGDIELRHVDFAYPARPD 1041
Query: 3089 VPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHL 3268
+ I + N+ ++ G++ ALVG SG GKSTVI+L+ER YDP G VT+D D+R++N K L
Sbjct: 1042 IQIFKDFNLKIQAGRSQALVGASGSGKSTVIALIERFYDPTGGKVTIDGKDIRRLNLKAL 1101
Query: 3269 RKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRV 3448
R I LV QEP+LF SI ENI YG T E++ A AN+H F+ +LP+GY+T V
Sbjct: 1102 RLKIGLVQQEPVLFAASILENIAYGKDGA--TEEEVIQAAKTANVHGFVSQLPNGYKTAV 1159
Query: 3449 GEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIV 3628
GE+G QLSGGQKQRIAIARA++++P ILLLDEATSALD ESE +Q AL+ K RT ++
Sbjct: 1160 GERGVQLSGGQKQRIAIARAVLKDPAILLLDEATSALDAESECVLQEALERLMKGRTTVL 1219
Query: 3629 VAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAK-RGAYFALTQKQ 3763
VAHRLSTI I VV++G++VE G+H++L+++ GAY L Q Q
Sbjct: 1220 VAHRLSTIRGVDRIAVVQDGRIVEHGSHSDLVSRPEGAYSRLLQLQ 1265
>gi|7508148|pir||T25082 hypothetical protein T21E8.2 - Caenorhabditis
elegans
Length = 1158
Score = 744 bits (1921), Expect = 0.0
Identities = 423/1134 (37%), Positives = 638/1134 (55%), Gaps = 10/1134 (0%)
Frame = +2
Query: 56 LYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAA 235
+++ TS ++ + +G+ S TG+ P +S +G +Q VT+ + ++
Sbjct: 31 IFKCTSCFEKFLFLIGVFFSLVTGLCQPFVSYTLGETAQVLVTITNAINNKTIDPADLKK 90
Query: 236 ARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAW 415
A ++ + Q L + GC F +Q + + + + R R+Q+ ++R++ +
Sbjct: 91 AYEQYERGMYQVVLYFFLCGCAYFTFASIQHAIMKYVGDNTTYRVRKQYISRLLRKDAEY 150
Query: 416 YDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLS 595
+D ++G LS L DNLER RE +K+ L F ++ F+ G A+AF DW L + S
Sbjct: 151 FDNVSTGHLSTVLNDNLERFREVFNEKIALIFALLTDFVVGTALAFYTDWRLASYGIFFS 210
Query: 596 PFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALE 775
+ G YA AG IA + L + +TV + NGQ E +RY + L+
Sbjct: 211 LGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQNTEIERYTEELK 270
Query: 776 HGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGS 955
G+K GI ++ + + + + +VG N +YSG LE V+ +F +M G+
Sbjct: 271 AGEKYGIHRALMYSISRGFTYFFCNSLNTVILYVGANMIYSGSLEPAVVVRIFHYMMFGA 330
Query: 956 MALGQAGQQFATIGTALGAAASLYEVI---DRIPEIDAYSTEGQTPSKISGRISVNKVEF 1126
L +A + + A+ + A + E++ D + E D T+ +++G IS V+F
Sbjct: 331 FCLSEALPHISRLAGAISSTAPIAEMLIKEDNVIEKD--ETDYDVEVEVNGNISFKNVKF 388
Query: 1127 TYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIE 1306
+YPTR D ++LKG+S D Q G+ +ALVG+SG GKST++QLL +YN D+G I ID + +
Sbjct: 389 SYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLN 448
Query: 1307 DFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEG 1486
D NIK LR+++GVVSQEP LFNT+IE+NIR+G +VS +I AL++ANA DF+ +FP+G
Sbjct: 449 DMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKG 508
Query: 1487 LNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRG 1666
+ T+VG+RG Q+SGGQKQRIAIAR LVRNPKILLLDEATSALD ESE +VQ ALENAS+G
Sbjct: 509 IKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQG 568
Query: 1667 RTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVDDKPK 1846
RTTIV+AHRLST+RNA KIIVM+ G+++EVG H+ LI ++G+Y++LV AQ+ DD
Sbjct: 569 RTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLESHDD--- 625
Query: 1847 KKEAERRMSRQTSQRKGSV-NFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXGAVK 2023
+E +RQ SQ + ++ Q S GA K
Sbjct: 626 HEELPPLAARQLSQELSPLHSYAIQRS-------TSNDAGVHDDDMERILDELSKEGAKK 678
Query: 2024 ANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHFW 2203
+NL +I++ RP++ + IQG P + + F+ D M H W
Sbjct: 679 SNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGED-MLYYSHLW 737
Query: 2204 ALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRIT 2383
AL F+ LA + ++ Q FG +E+L+ R+R K + ++L ++D P HS R++
Sbjct: 738 ALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLS 797
Query: 2384 TRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALM 2563
RL TD+ N+K+A+D RLG + + ++ + A Y W+M V+ FP + + +
Sbjct: 798 NRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLIFFPLLYLAEYCY 857
Query: 2564 MKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKA 2743
S D EN+ +TA+EA+EN+RTV+AL L+ K+ ++ HL H +A
Sbjct: 858 DAATETSIQEDTIAFENSNRTAIEALENMRTVRALNLEDKIMSLISEHLQKIHKSYFKRA 917
Query: 2744 IIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAAS 2923
II+G G + S F Y+ +F+FG +L K V P + +L +S + G AA+
Sbjct: 918 IIQGAANGLSLSCYLFVYSVSFKFGTYLALRKEV--APMDTYLILETLSMTANMAGSAAA 975
Query: 2924 YFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVFFRYPERPAVPILQ 3103
Y P+Y KA AAGLIF++ + +S G GE+ V F Y +RP IL
Sbjct: 976 YLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILN 1035
Query: 3104 GLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVT------VDNNDLRQMNPKH 3265
G+N+ V PG+TLALVGPSGCGKST+ISLLER Y ++G V +D+ ++ +N H
Sbjct: 1036 GVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVVSIDAHKIDSENVEDINLNH 1095
Query: 3266 LRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELP 3427
LR ++ALVSQEP LF+ SIREN++YGL ++E A AN F+ + P
Sbjct: 1096 LRSNLALVSQEPTLFNCSIRENLLYGL-TRSVPQLELEKALQTANAFNFVFQFP 1148
Score = 299 bits (766), Expect = 3e-79
Identities = 201/540 (37%), Positives = 286/540 (52%), Gaps = 10/540 (1%)
Frame = +2
Query: 2174 DQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFD 2353
+Q ++ + L F + T Q ++ + T R+R + +LR+DA YFD
Sbjct: 93 EQYERGMYQVVLYFFLCGCAYFTFASIQHAIMKYVGDNTTYRVRKQYISRLLRKDAEYFD 152
Query: 2354 MPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMA----FLV 2521
S G ++T L + + + ++ IF + G +AFY W++A F
Sbjct: 153 --NVSTGHLSTVLNDNLERFREVFNEKIALIFALLTDFVVGTALAFYTDWRLASYGIFFS 210
Query: 2522 MAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFC 2701
+ I + A +MK G T A NAG A + + +TV +L Q +
Sbjct: 211 LGIAFSGFINSAGVMKTTGKQNTHYA----NAGSIAFQTLGAYKTVCSLNGQNTEIERYT 266
Query: 2702 SHLDAPHGGNISKAII----RGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVL 2869
L A I +A++ RG TY F NS+ G +I+ + +EP V+
Sbjct: 267 EELKAGEKYGIHRALMYSISRGFTYFFCNSLN----TVILYVGANMIYSGS--LEPAVVV 320
Query: 2870 RVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRI--DGMTSSGTYPQLSGE 3043
R+ + F + A + A + I ML +E + T +++G
Sbjct: 321 RIFHYMMFGAFCLSEALPHISRLAGAISSTAPIAEMLIKEDNVIEKDETDYDVEVEVNGN 380
Query: 3044 VKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAV 3223
+ V F YP RP +L+G++ V+ G+ +ALVG SG GKSTV+ LL Y+ G +
Sbjct: 381 ISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNI 440
Query: 3224 TVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANI 3403
+D DL MN K LR+ I +VSQEP+LF+T+I ENI +G + +I A KAN
Sbjct: 441 FIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNP--NVSLPEIYGALRKANA 498
Query: 3404 HKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQV 3583
+ F+ P G +T VGE+GTQLSGGQKQRIAIAR L+RNPKILLLDEATSALD ESE+ V
Sbjct: 499 YDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVV 558
Query: 3584 QVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQ 3763
Q AL+ A++ RT IVVAHRLSTI NA I+V++ G++VE G H+ELIAKRG Y L Q Q
Sbjct: 559 QKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQ 618
Score = 161 bits (408), Expect = 1e-37
Identities = 128/477 (26%), Positives = 211/477 (43%), Gaps = 9/477 (1%)
Frame = +2
Query: 80 DRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHE 259
D L + + S GV P+++ ++ + F +G L +SH
Sbjct: 691 DYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDML--------------YYSHL 736
Query: 260 VIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYDK-NTSG 436
L +++L + Q F + E+LS R R + F ++ A+YD N S
Sbjct: 737 W---ALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSA 793
Query: 437 T-LSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMIC 613
T LSN+L + V+ D++G + A Y W +TL ++ P + +
Sbjct: 794 TRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLIFFPLLYLA 853
Query: 614 GLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTG 793
+ + A E L ++RTV A N ++ + L+ K+
Sbjct: 854 EYCYDAATETSIQEDTIAFENSNRTAIEALENMRTVRALNLEDKIMSLISEHLQKIHKSY 913
Query: 794 IKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQA 973
K++ + GA Y ++F GT + + ++ M + G A
Sbjct: 914 FKRAIIQGAANGLSLSCYLFVYSVSFKFGTYLALRKEVAPMDTYLILETLSMTANMAGSA 973
Query: 974 GQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVK 1153
A+ AA ++ + + S++G+ + G I V+F Y R D
Sbjct: 974 AAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIE-KGEIIGENVQFHYDQRPDRM 1032
Query: 1154 ILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQIL------IDDIPIEDFN 1315
IL GV+L PG+T+ALVG SGCGKSTII LL+RFY+ G+++ ID +ED N
Sbjct: 1033 ILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVVSIDAHKIDSENVEDIN 1092
Query: 1316 IKYLRQLVGVVSQEPNLFNTSIEQNIRYGRS-DVSDEDIARALKEANAADFIKTFPE 1483
+ +LR + +VSQEP LFN SI +N+ YG + V ++ +AL+ ANA +F+ FP+
Sbjct: 1093 LNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQ 1149
>gi|7493911|pir||T30882 multidrug resistance protein 1 - Aspergillus
flavus
gi|2673947|gb|AAB88655.1| multidrug resistance protein 1 [Aspergillus
flavus]
gi|2673949|gb|AAB88656.1| multidrug resistance protein 1 [Aspergillus
flavus]
Length = 1307
Score = 742 bits (1915), Expect = 0.0
Identities = 447/1277 (35%), Positives = 681/1277 (53%), Gaps = 30/1277 (2%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
I F +YRY + D +L + + A G LPL +++ G ++ F + T + +
Sbjct: 45 IGFFGIYRYATRWDVAILFGSALAAIAGGAALPLFTVLFGRLTSTFQDIATHRITYD--- 101
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
F HE+ +N + ++YLG F A +L F+ + + + R ++F +++R
Sbjct: 102 --------HFHHELTKNVVYFIYLGAAEFVAIYLATVGFIYTGDHVVQQIRVEYFQAILR 153
Query: 401 QEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLI 580
Q IA++D +G ++ ++ + +++G +KVGLA ++ F+ F +A+ +W L LI
Sbjct: 154 QNIAFFDTLGAGEITTRITADTNLIQDGISEKVGLALTGLSTFVTAFIIAYIKNWKLALI 213
Query: 581 MMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGG-IAEEVLTSIRTVIAFNGQEYECKR 757
S S ++ + +Y G +AE++L SIRTV AFN QE ++
Sbjct: 214 C-SASLLALLLTMGGCSTLMLIFSKKALEYQGRGASMAEDILDSIRTVAAFNAQETLARK 272
Query: 758 YEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSG--RLESGTVLTV 931
YE L+ + G+K + + + I+Y +Y L FW+G+ F+ G +++G VLT+
Sbjct: 273 YESHLKDAEGPGMKSKVIFAIMVGALLCIMYLNYGLGFWMGSRFLVEGISNIKAGDVLTI 332
Query: 932 FFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISV 1111
++++GS LG + A+ AA+ LY IDR +DA S +G+T + G I +
Sbjct: 333 MMAIILGSYNLGNVAPNGQALSDAVAAASKLYGTIDRQSPLDALSDQGKTLEFVRGNIVL 392
Query: 1112 NKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILID 1291
+ YP+R +V + +S G+T A VG SG GKSTII LL+RFY+P AG I++D
Sbjct: 393 QNIRHVYPSRPEVTVAHDLSCYIPAGKTTAFVGPSGSGKSTIISLLERFYDPVAGTIMLD 452
Query: 1292 DIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDED---------IARALK 1444
I+ N+++LRQ + +VSQEP LF T+I +NIRYG E + A +
Sbjct: 453 GHDIQTLNLRWLRQQMSLVSQEPRLFATTIAENIRYGIIGSRFEKESTYEIRKRVEAAAR 512
Query: 1445 EANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAES 1624
ANA DFI P G +T + +SGGQKQRIAIARA++++PKILLLDEATSALD +S
Sbjct: 513 MANAHDFIMALPNGYDTNI--ESFSLSGGQKQRIAIARAIIKDPKILLLDEATSALDTKS 570
Query: 1625 ESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHEL 1804
E +VQ+AL+ AS+GRTTIVIAHRLST++ A IIV+ GQ++E G HE L++++G+Y ++
Sbjct: 571 EKLVQAALDKASKGRTTIVIAHRLSTIQKAYNIIVLANGQIVEQGPHEHLMDRRGIYCDM 630
Query: 1805 VHAQVFADVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXX 1984
V A + K+ ++ + + F D
Sbjct: 631 VEAHEIKKRYSRYSKRYSQLLTNLSPKHNPMTFFFDKDYPGDDESDIYSILSDDASDIGL 690
Query: 1985 XXXXXXXXXGAVKAN---------------LFKIL-RYARPEWIYXXXXXXXXLIQGAVM 2116
+ + LFK L + RPEW + ++ G +
Sbjct: 691 HTGEKQRPVSRMSLSHLMQPVKEEAYSFWTLFKFLASFNRPEWPFLLLGLCASILAGGIQ 750
Query: 2117 PAFSLFFSQIINVFSNP--DRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERL 2290
P+ ++ F++ ++ S P + +++ D +FW LMFL++ V Q +LF ++E++
Sbjct: 751 PSQAVLFAKAVSTLSLPPLEYPKLRHDANFWCLMFLMIGIVSLVLYSVQGTLFAYSSEKM 810
Query: 2291 TMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVG 2470
R RS+ +R +L QD ++FD +++ G +T L+ + LG+I ++
Sbjct: 811 VYRARSQAFRVILHQDISFFDQQENTTGALTATLSAGTKELTGISGVTLGTILIVSVNLV 870
Query: 2471 GGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENI 2650
LG+A GW++A + ++ P + + + + K + + +A EA I
Sbjct: 871 ASLGVALVIGWKLALVCISAVPALLMCGFVRVWMLERFQRRAKKAYQESASSACEAASAI 930
Query: 2651 RTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLI 2830
RTV +LT++T+ + + L +I + L Y + ++ FF A F +G L+
Sbjct: 931 RTVVSLTMETEALQSYQAQLRRQLKSDILPIVKSSLLYASSQALPFFCMALGFWYGGSLL 990
Query: 2831 FDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMT 3010
+ V + F G S+ P+ KA AA + + +
Sbjct: 991 GHGEYSLFQFYV--CFSEVIFGAQAAGTVFSHAPDMGKAKHAAREFKRLFSSDTMHASRS 1048
Query: 3011 SSGTYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLL 3190
+ G V+ V FRYP R PIL+ LN+ +KPGQ +ALVG SG GKST I+LL
Sbjct: 1049 KGVPVTSMRGLVEFRDVSFRYPSRLEQPILRHLNLTIKPGQFVALVGASGSGKSTTIALL 1108
Query: 3191 ERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHE 3370
ER YDPL+G V VD ++ + R H+AL+SQEP LF +IRENI+ G T +
Sbjct: 1109 ERFYDPLKGGVYVDGKNIITLEMSSYRSHLALISQEPTLFQGTIRENILLGSNTPHVTDD 1168
Query: 3371 QIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEAT 3550
+ AC ANI+ FI LP G+ T VG KG LSGGQKQRIAIARALIRNPKILLLDEAT
Sbjct: 1169 FLVKACKDANIYDFILSLPQGFNTIVGNKGGMLSGGQKQRIAIARALIRNPKILLLDEAT 1228
Query: 3551 SALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAK 3730
SALD+ESEK VQ ALDAAA+ RT I VAHRLSTI A I V+ G+VVE GTH EL+ K
Sbjct: 1229 SALDSESEKVVQAALDAAARGRTTIAVAHRLSTIQRADLIYVLDQGEVVESGTHRELLRK 1288
Query: 3731 RGAYFALTQKQSSNQSG 3781
+G Y+ L Q+ + +G
Sbjct: 1289 KGRYYELVHLQNPDATG 1305
>gi|6671365|gb|AAF23176.1| P-glycoprotein [Gossypium hirsutum]
Length = 1249
Score = 741 bits (1912), Expect = 0.0
Identities = 441/1262 (34%), Positives = 689/1262 (53%), Gaps = 17/1262 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+ + +L+ + D +++ +G + +C G +P+ I G + +G +L P
Sbjct: 28 VPLLKLFSFADFYDHVLMGLGSLGACVHGASVPVFFIFFGKLIN---IIGMAYLFPK--- 81
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
E SH+V + L +VYL I + +++ +C+M E+ + + R + S++
Sbjct: 82 --------EASHKVAKYSLDFVYLSVAILFSSWIEVACWMHTGERQAAKMRMAYLKSMLN 133
Query: 401 QEIAWYDKNTS-GTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
Q+I+ +D S G + + + ++ V++ +KVG +++FI GF++ F W ++L
Sbjct: 134 QDISLFDTEASTGEVISAITSDIIVVQDALSEKVGNFMHYISRFIAGFSIGFARVWQISL 193
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
+ +S+ P + + G Y AG IAEEV+ ++RTV AF G+E K
Sbjct: 194 VTLSIVPLIALAGGIYAYVATGLIARVRNSYVKAGEIAEEVIGNVRTVQAFAGEERAVKS 253
Query: 758 YEDAL----EHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVL 925
Y+DAL +GKK G+ K G GL S +++ S+ L W + V+ G
Sbjct: 254 YKDALMNTYTYGKKAGLTK----GLGLGSLHCVLFVSWALLVWFTSIVVHKNIANGGDSF 309
Query: 926 TVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRI 1105
T +V++ ++LGQA + A AA ++E+I+R S G+ SK+ G I
Sbjct: 310 TTMLNVVISGLSLGQAAPDISAFIRARAAAYPIFEMIERNTVSKTSSKTGRKLSKVEGNI 369
Query: 1106 SVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQIL 1285
+ V F+YP+R DV I L+ G+ VALVG SG GKST+I L++RFY P AG+IL
Sbjct: 370 ELKNVSFSYPSRPDVVIFDRFCLNIPTGKIVALVGGSGSGKSTVISLIERFYEPLAGEIL 429
Query: 1286 IDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADF 1465
+D I+ ++K+LRQ +G+V+QEP LF T+I +NI YG+ D + ++I RA K + A F
Sbjct: 430 LDGNNIKGLDLKWLRQQIGLVNQEPALFATTIRENILYGKDDATVDEITRAAKLSEAIAF 489
Query: 1466 IKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSA 1645
I P+ T VG+RG+Q+SGGQKQRIAI+RA+V+NP ILLLDEATSALDAESE VQ A
Sbjct: 490 INNLPDRFETQVGERGIQLSGGQKQRIAISRAIVKNPPILLLDEATSALDAESEKSVQEA 549
Query: 1646 LENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQ-KGLYHELVHAQVF 1822
L+ GRTT+V+AHRLST+RNAD I V++ G+++E GTH+ LI Y LV Q
Sbjct: 550 LDRVMVGRTTVVVAHRLSTIRNADVIAVVQNGKIVETGTHDELISNPNSTYSSLVQHQET 609
Query: 1823 ADVDDKPKKKEAERR-----MSRQTSQRKGS--VNFKTQESQVDXXXXXXXXXXXXXXXX 1981
+ + P + R SR+ S+ + S +F+++ V
Sbjct: 610 SPLQRYPSQGPTLSRPLSVSYSRELSRTRTSFGASFRSERDSVSRAGADGIDAGKQPYVS 669
Query: 1982 XXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFS 2161
L+ ++ P+W Y LI GA MP F+L SQ + V
Sbjct: 670 -------------PGRLYSMI---GPDWYYGFFGTVTALIAGAQMPLFALGVSQAL-VAY 712
Query: 2162 NPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDA 2341
D + + A++F + + + FG+ ERLT+R+R ++ +L+ +
Sbjct: 713 YMDWETTCHEVKKIAILFCCASVITVIVHAIEHLCFGIMGERLTLRVREGMFSAILKNEI 772
Query: 2342 TYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLV 2521
+FD ++ + +RL TDA ++ + R + + V IAF W++ ++
Sbjct: 773 GWFDDLNNASSMLASRLETDATFLRGVVVDRTSILIQNVGLVIAAFIIAFILNWRITLII 832
Query: 2522 MAIFPFMAVG---QALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYN 2692
+A FP + G + L M+ +GG+ +K A A EA+ N+RTV A + K+ +
Sbjct: 833 LATFPLIISGHISEKLFMQGYGGNL---SKAYLKANMIAGEAVSNMRTVAAFCAEEKILD 889
Query: 2693 IFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLR 2872
++ L P + + I G+ YG + F +Y A +G L+ + L ++V++
Sbjct: 890 LYARELIEPSERSFKRGQIAGIFYGISQFFIFSSYGLALWYGSVLMGKE--LASFKSVMK 947
Query: 2873 VLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKL 3052
+ + +G + P+ +K +F +++ + ++ G + + G ++L
Sbjct: 948 SFMVLIVTALAMGETLALVPDLLKGNQMVASVFEIMDRKTQVVG-DAGEELTNVEGTIEL 1006
Query: 3053 NKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVD 3232
V F YP RP V I + ++ V+ G+++ALVG SG GKS+V++L+ R YDP G V +D
Sbjct: 1007 KGVHFSYPSRPDVVIFKDFDLKVRSGKSMALVGQSGSGKSSVLALILRFYDPTSGKVMID 1066
Query: 3233 NNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKF 3412
D++++ K LRKHI LV QEP LF TSI ENI+YG + + ++ A AN H F
Sbjct: 1067 GRDVKKLKLKSLRKHIGLVQQEPALFATSIYENILYGKEGA--SESEVVEAAKLANAHSF 1124
Query: 3413 IDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVA 3592
I LP+GY T+VGE+G QLSGGQKQR+AIARA+++NP+ILLLDEATSALD ESE+ VQ A
Sbjct: 1125 ISSLPEGYSTKVGERGVQLSGGQKQRVAIARAVLKNPEILLLDEATSALDVESERVVQQA 1184
Query: 3593 LDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKR-GAYFALTQKQSS 3769
LD ++RT ++VAHRLSTI NA I V++ G+++EQGTH+ LI R G YF L Q
Sbjct: 1185 LDRLMRNRTTVMVAHRLSTIKNADRISVIQGGRIIEQGTHSSLIENRNGPYFKLINLQQQ 1244
Query: 3770 NQ 3775
Q
Sbjct: 1245 QQ 1246
>gi|46390962|dbj|BAD16475.1| putative multidrug resistance
p-glycoprotein [Oryza sativa (japonica cultivar-group)]
Length = 1245
Score = 737 bits (1903), Expect = 0.0
Identities = 455/1255 (36%), Positives = 679/1255 (53%), Gaps = 11/1255 (0%)
Frame = +2
Query: 44 SIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTAS 223
S ++ + D ++ +G++ + G+ P+M +I + F LG+
Sbjct: 19 SFMTVFMHADAADVALMVLGLLGAMGDGISTPVMLLITSRI---FNDLGS---------- 65
Query: 224 EKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQ 403
A EFS +V N V+L + FL+ C+ E+ ++R R ++ +V+RQ
Sbjct: 66 -GADIVKEFSSKVNVNARNLVFLAAASWVMAFLEGYCWARTAERQASRMRARYLRAVLRQ 124
Query: 404 EIAWYD--KNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
++ ++D K ++ + + ++ V++ +KV A F G +AV F W LTL
Sbjct: 125 DVEYFDLKKGSTAEVITSVSNDSLVVQDVLSEKVPNFVMNAAMFAGSYAVGFALLWRLTL 184
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
+ + ++I G QY G IAE+ ++S RTV +F + +
Sbjct: 185 VALPSVVLLIIPGFMYGRILVGLARRIREQYTRPGAIAEQAVSSARTVYSFVAERTTMAQ 244
Query: 758 YEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFF 937
+ ALE + G+K+ G + S I +A + W G+ V + GTV V
Sbjct: 245 FSAALEESARLGLKQGLAKGIAVGSNG-ITFAIWAFNVWYGSRLVMYHGYQGGTVFAVSA 303
Query: 938 SVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNK 1117
++++G +ALG A AA + EVI R+P+ID+ S G+ + ++G +
Sbjct: 304 AIVVGGLALGSGLSNVKYFSEASSAAERILEVIRRVPKIDSESDTGEELANVTGEVEFRN 363
Query: 1118 VEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDI 1297
VEF YP+R + I +L G+TVALVG SG GKST+I LL+RFY+P AG++++D +
Sbjct: 364 VEFCYPSRPESPIFVSFNLRVPAGRTVALVGGSGSGKSTVIALLERFYDPSAGEVMVDGV 423
Query: 1298 PIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTF 1477
I +K+LR +G+VSQEP LF TSI +NI +G+ + + E++ A K ANA +FI
Sbjct: 424 DIRRLRLKWLRAQMGLVSQEPALFATSIRENILFGKEEATAEEVVAAAKAANAHNFISQL 483
Query: 1478 PEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENA 1657
P+G +T VG+RGVQMSGGQKQRIAIARA++++PKILLLDEATSALD ESE +VQ AL+ A
Sbjct: 484 PQGYDTQVGERGVQMSGGQKQRIAIARAILKSPKILLLDEATSALDTESERVVQEALDLA 543
Query: 1658 SRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLI-EQKGLYHELVHAQVFADVD 1834
S GRTTIVIAHRLST+RNAD I VM++G+V E+G H+ LI GLY LV Q D +
Sbjct: 544 SMGRTTIVIAHRLSTIRNADIIAVMQSGEVKELGPHDELIANDNGLYSSLVRLQQTRDSN 603
Query: 1835 DKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXG 2014
+ E ++ TS +V + S
Sbjct: 604 EID-----EIGVTGSTS----AVGQSSSHSMSRRFSAASRSSSARSLGDARDDDNTEKPK 654
Query: 2015 AVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDG 2194
+ ++L PEW ++ G + PA++ +I+V+ D ++K
Sbjct: 655 LPVPSFRRLLMLNAPEWKQALMGSFSAVVFGGIQPAYAYAMGSMISVYFLTDHAEIKDKT 714
Query: 2195 HFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPG 2374
+AL+F+ LA + + Q FG E LT RIR ++ +L + +FD ++S G
Sbjct: 715 RTYALIFVGLAVLSFLINIGQHYNFGAMGEYLTKRIREQMLAKILTFEIGWFDRDENSSG 774
Query: 2375 RITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAV-- 2548
I ++LA DA ++S + R+ + I++V + W++A +++A+ P + V
Sbjct: 775 AICSQLAKDANVVRSLVGDRMALVIQTISAVLIACTMGLVIAWRLALVMIAVQPLIIVCF 834
Query: 2549 -GQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHG 2725
+ +++K + + K A EA+ N+RT+ A + Q ++ +F D P
Sbjct: 835 YARRVLLK---SMSKKSIHAQAESSKLAAEAVSNLRTITAFSSQERILRLFEQSQDGPRK 891
Query: 2726 GNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFG- 2902
+I ++ GL G + S+ T+A F +G L+ + ++ + L F I S G
Sbjct: 892 ESIRQSWFAGLGLGTSMSLMTCTWALDFWYGGRLMAEHHISAKE---LFQTFMILVSTGR 948
Query: 2903 TIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKLNKVFFRYPE 3079
I A S + K A +F +L+ E ID G P+ L GEV + V F YP
Sbjct: 949 VIADAGSMTTDLAKGADAVASVFAVLDRETEIDPDNPQGYKPEKLKGEVDIRGVDFAYPS 1008
Query: 3080 RPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNP 3259
RP V I +G + ++PG++ ALVG SG GKST+I L+ER YDP+ G+V +D D++ N
Sbjct: 1009 RPDVIIFKGFTLSIQPGKSTALVGQSGSGKSTIIGLIERFYDPIRGSVKIDGRDIKAYNL 1068
Query: 3260 KHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYE 3439
+ LR+HI LVSQEP LF +IRENIVYG + + +IE A AN H FI L DGY+
Sbjct: 1069 RALRRHIGLVSQEPTLFAGTIRENIVYGTETA--SEAEIEDAARSANAHDFISNLKDGYD 1126
Query: 3440 TRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRT 3619
T GE+G QLSGGQKQRIAIARA+++NP ILLLDEATSALD++SEK VQ ALD RT
Sbjct: 1127 TWCGERGVQLSGGQKQRIAIARAILKNPAILLLDEATSALDSQSEKVVQEALDRVMIGRT 1186
Query: 3620 CIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAK--RGAYFALTQ-KQSSNQ 3775
+VVAHRLSTI N I V++ G VVE+GTH L+AK G YF+L +Q NQ
Sbjct: 1187 SVVVAHRLSTIQNCDLITVLEKGTVVEKGTHASLMAKGLSGTYFSLVNLQQGGNQ 1241
Score = 328 bits (840), Expect = 8e-88
Identities = 206/526 (39%), Positives = 293/526 (55%), Gaps = 7/526 (1%)
Frame = +2
Query: 2222 LAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATD 2401
LAA + + AER R+R++ R VLRQD YFD+ K S + T ++ D
Sbjct: 87 LAAASWVMAFLEGYCWARTAERQASRMRARYLRAVLRQDVEYFDLKKGSTAEVITSVSND 146
Query: 2402 APNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFL-----VMAIFPFMAVGQALMM 2566
+ ++ + ++ + A G + F W++ + V+ I P G+ L+
Sbjct: 147 SLVVQDVLSEKVPNFVMNAAMFAGSYAVGFALLWRLTLVALPSVVLLIIPGFMYGRILV- 205
Query: 2567 KYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAI 2746
G A ++ G A +A+ + RTV + + F + L+ + + +
Sbjct: 206 ----GLARRIREQYTRPGAIAEQAVSSARTVYSFVAERTTMAQFSAALEESARLGLKQGL 261
Query: 2747 IRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASY 2926
+G+ G +N I F +A +G L+ + V V AI +G S
Sbjct: 262 AKGIAVG-SNGITFAIWAFNVWYGSRLVMYHGY--QGGTVFAVSAAIVVGGLALGSGLSN 318
Query: 2927 FPEYIKATFAAGLIFNMLEEEPRIDGMTSSGT-YPQLSGEVKLNKVFFRYPERPAVPILQ 3103
+ +A+ AA I ++ P+ID + +G ++GEV+ V F YP RP PI
Sbjct: 319 VKYFSEASSAAERILEVIRRVPKIDSESDTGEELANVTGEVEFRNVEFCYPSRPESPIFV 378
Query: 3104 GLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIA 3283
N+ V G+T+ALVG SG GKSTVI+LLER YDP G V VD D+R++ K LR +
Sbjct: 379 SFNLRVPAGRTVALVGGSGSGKSTVIALLERFYDPSAGEVMVDGVDIRRLRLKWLRAQMG 438
Query: 3284 LVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGT 3463
LVSQEP LF TSIRENI++G + E T E++ A AN H FI +LP GY+T+VGE+G
Sbjct: 439 LVSQEPALFATSIRENILFGKE--EATAEEVVAAAKAANAHNFISQLPQGYDTQVGERGV 496
Query: 3464 QLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRL 3643
Q+SGGQKQRIAIARA++++PKILLLDEATSALDTESE+ VQ ALD A+ RT IV+AHRL
Sbjct: 497 QMSGGQKQRIAIARAILKSPKILLLDEATSALDTESERVVQEALDLASMGRTTIVIAHRL 556
Query: 3644 STIVNAGCIMVVKNGQVVEQGTHNELIAK-RGAYFALTQKQSSNQS 3778
STI NA I V+++G+V E G H+ELIA G Y +L + Q + S
Sbjct: 557 STIRNADIIAVMQSGEVKELGPHDELIANDNGLYSSLVRLQQTRDS 602
>gi|24659289|ref|NP_648040.1| CG10226-PA [Drosophila melanogaster]
gi|7295352|gb|AAF50670.1| CG10226-PA [Drosophila melanogaster]
Length = 1320
Score = 733 bits (1892), Expect = 0.0
Identities = 436/1286 (33%), Positives = 681/1286 (52%), Gaps = 44/1286 (3%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFV--TLG----TIFL 202
+S +L+RY + D L+L G + + + P+ ++ + F+ TLG ++ +
Sbjct: 36 VSYTELFRYIAGWDYLVLLSGFVAAFLQSLVFPIAIVVYSELVAMFIERTLGQGTSSVTI 95
Query: 203 DPNSTASEKAAARAEFSHEVIQNCLKYVYLGCGIFA---------AGFLQASCFMVICEK 355
+ K A + + + L+ + GI +G F + K
Sbjct: 96 GLSLFGGGKILTNASYEENMQE--LRKDSVSFGILMTLNTLLMLFSGVYYVDAFNRLALK 153
Query: 356 LSNRFRRQFFHSVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIG 535
L+ R RR+FF + +RQEI W+D + ++ DN+E++R G + +G ++M I
Sbjct: 154 LTVRMRREFFKATLRQEIGWHDMAKDQNFAVRITDNMEKIRSGIAENLGHYVEIMCDVII 213
Query: 536 GFAVAFTYDWLLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIR 715
++F Y W L L ++ P ++ Y A + EEV+ +IR
Sbjct: 214 SVVLSFIYGWKLALAIVFYIPLTLVVNSAVAHYQGKLTGQEQSSYVRASSVVEEVIGAIR 273
Query: 716 TVIAFNGQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVY 895
TV+AF G+ E RY+ L+ K G K G +++ + +FW G N +
Sbjct: 274 TVVAFGGERSESLRYDSLLKPALKAGKWKGAFSGLSDTVMKAMLFITGAGSFWYGANLIL 333
Query: 896 SGRLES----------GTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRI 1045
R S V+ V +++ + + + T A G+A+++ +VIDR
Sbjct: 334 YYRDPSIPIDEREYTPAVVMIVISGIIVSANQISRTSPFLETFAMARGSASAILDVIDRT 393
Query: 1046 PEIDAYSTEGQTPSK-ISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGC 1222
ID S G+ + + G + V F YP R DV +L+G+++ + GQTVALVG SGC
Sbjct: 394 SLIDPLSKAGKILNYGLKGAVEFRDVFFRYPAREDVIVLRGLNVVVEEGQTVALVGPSGC 453
Query: 1223 GKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYG 1402
GKST IQLLQRFY+P GQ+L+D + +NIK+LR + VV QEP LF SI +NIR+G
Sbjct: 454 GKSTCIQLLQRFYDPVFGQVLLDGEDVRKYNIKWLRSNIAVVGQEPVLFQGSIGENIRHG 513
Query: 1403 RSDVSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKI 1582
+ + + +++ A K ANA DFI +G +T + ++GVQ+SGGQ+QRIAIARAL++ PKI
Sbjct: 514 KPEATQKEVEDAAKAANAHDFIIALHKGYDTDISEKGVQLSGGQRQRIAIARALIQQPKI 573
Query: 1583 LLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGT 1762
LLLDEATSALD SE +VQ+AL+ A +GRTT+V++HRLS +R+A +I+ ++ G+ +E GT
Sbjct: 574 LLLDEATSALDYHSEKLVQAALDKACKGRTTLVVSHRLSAIRHAHRIVYIENGKAVEQGT 633
Query: 1763 HETLIEQKGLYHELVHAQVFADVDDK--PKKKEAERRMSRQTSQRKGSVNFKTQESQVDX 1936
HE L++ +G YH++V + D ++ + +E R+ S T+ S V
Sbjct: 634 HEELMKLEGFYHKMVTVHSYDDSAEELLNELEEVAEIKERKMSYEVEPYQLGTRNSIVSL 693
Query: 1937 XXXXXXXXXXXXXXXXXXXXXXXXXGAVKA-----NLFKILRYARPEWIYXXXXXXXXLI 2101
V + F+IL +ARPEW + +
Sbjct: 694 EKNAEFQMKNLNGLANITMNQEIDDPRVPSANFISTFFRILGWARPEWSFLIIGAICAGL 753
Query: 2102 QGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAA 2281
G MP FS+ +++ + P +++ + A++ LV+ G Q F +A
Sbjct: 754 YGVTMPVFSVVLAELYGSLAKPTDEEVLEQSASMAIISLVIGIAAGVVCYIQTFFFNLAG 813
Query: 2282 ERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIA 2461
LT R+RSK +R ++ Q+ +FD ++S G ++ RL+ DA +++ AI + L +I A
Sbjct: 814 VWLTTRMRSKTFRCIMNQEMGWFDRKENSIGALSARLSGDAASVQGAIGFPLSNIIQAFT 873
Query: 2462 SVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAI 2641
+ + IAF Y W++A + ++ PFM ++ SA + + +E + A E I
Sbjct: 874 NFICSIAIAFPYSWELALICLSTSPFMVASIVFEARFGEKSALKEKEVLEETSRIATETI 933
Query: 2642 ENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGL 2821
IRTV L + +L I+ ++ +S+ RGL S+ FF YA +G
Sbjct: 934 TQIRTVAGLRREEELIKIYDKEVERYRHQILSRLKWRGLVNSLGKSLMFFGYAVTLTYGG 993
Query: 2822 FLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRID 3001
+ D + E ++++ + + + + ++ P + A +A ++ +++ +P+I
Sbjct: 994 HMCADGKIKFE--TIMKISNTMLYGLFILAQSLAFTPAFNAALLSANRMYEIIDRKPQIQ 1051
Query: 3002 GMTSSGTYPQLSGEVKLNKVF----------FRYPERPAVPILQGLNVHVKPGQTLALVG 3151
S +G V F YP RP + +LQ N+ + GQT+ALVG
Sbjct: 1052 SPESFEIQQNGNGTAYKTNVVQQGVSYRGLNFSYPSRPHIKVLQNFNLDINQGQTVALVG 1111
Query: 3152 PSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQ-MNPKHLRKHIALVSQEPILFDTSIRE 3328
SG GKST + LL R YDP EG + +D + M+ K LR+ + +VSQEP LF+ SI +
Sbjct: 1112 ASGSGKSTCVQLLMRYYDPDEGKILIDQESIHHDMDLKTLRRRLGIVSQEPSLFEKSIAD 1171
Query: 3329 NIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARA 3508
NI YG + +QI A AN H+FI LP Y+T +G KGTQLSGGQKQRIAIARA
Sbjct: 1172 NIGYGDTSRQVPMQQIIEAAKMANAHEFIMSLPAQYDTVLGSKGTQLSGGQKQRIAIARA 1231
Query: 3509 LIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNG 3688
++RNPKILLLDEATSALD +SE+ VQ ALD+A RTCIV+AHRLSTI NA I V++ G
Sbjct: 1232 MVRNPKILLLDEATSALDFQSERVVQQALDSACSGRTCIVIAHRLSTIQNANVICVIQAG 1291
Query: 3689 QVVEQGTHNELIAKRGAYFALTQKQS 3766
++VEQG+H++L+AK G Y L + Q+
Sbjct: 1292 KIVEQGSHSQLLAKNGIYSKLYRCQT 1317
Score = 338 bits (868), Expect = 5e-91
Identities = 210/592 (35%), Positives = 321/592 (53%), Gaps = 14/592 (2%)
Frame = +2
Query: 92 LAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHEVIQN 271
L +G I + GV +P+ S+++ + G++ + E++A+ A S
Sbjct: 744 LIIGAICAGLYGVTMPVFSVVLAEL------YGSLAKPTDEEVLEQSASMAIIS------ 791
Query: 272 CLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYDK--NTSGTLS 445
+ +G ++Q F + L+ R R + F +M QE+ W+D+ N+ G LS
Sbjct: 792 ----LVIGIAAGVVCYIQTFFFNLAGVWLTTRMRSKTFRCIMNQEMGWFDRKENSIGALS 847
Query: 446 NKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFX 625
+L + V+ G + Q FI A+AF Y W L LI +S SPFM+ +F
Sbjct: 848 ARLSGDAASVQGAIGFPLSNIIQAFTNFICSIAIAFPYSWELALICLSTSPFMVASIVFE 907
Query: 626 XXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKS 805
IA E +T IRTV +E K Y+ +E + + +
Sbjct: 908 ARFGEKSALKEKEVLEETSRIATETITQIRTVAGLRREEELIKIYDKEVERYRHQILSRL 967
Query: 806 FLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQF 985
G + +++ Y + G + G+++ T++ + +++ G L Q+
Sbjct: 968 KWRGLVNSLGKSLMFFGYAVTLTYGGHMCADGKIKFETIMKISNTMLYGLFILAQSLAFT 1027
Query: 986 ATIGTALGAAASLYEVIDRIPEIDAYST---------EGQTPSKISGRISVNKVEFTYPT 1138
AL +A +YE+IDR P+I + + + + +S + F+YP+
Sbjct: 1028 PAFNAALLSANRMYEIIDRKPQIQSPESFEIQQNGNGTAYKTNVVQQGVSYRGLNFSYPS 1087
Query: 1139 RADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIE-DFN 1315
R +K+L+ +LD GQTVALVG+SG GKST +QLL R+Y+PD G+ILID I D +
Sbjct: 1088 RPHIKVLQNFNLDINQGQTVALVGASGSGKSTCVQLLMRYYDPDEGKILIDQESIHHDMD 1147
Query: 1316 IKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSD--VSDEDIARALKEANAADFIKTFPEGL 1489
+K LR+ +G+VSQEP+LF SI NI YG + V + I A K ANA +FI + P
Sbjct: 1148 LKTLRRRLGIVSQEPSLFEKSIADNIGYGDTSRQVPMQQIIEAAKMANAHEFIMSLPAQY 1207
Query: 1490 NTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGR 1669
+T++G +G Q+SGGQKQRIAIARA+VRNPKILLLDEATSALD +SE +VQ AL++A GR
Sbjct: 1208 DTVLGSKGTQLSGGQKQRIAIARAMVRNPKILLLDEATSALDFQSERVVQQALDSACSGR 1267
Query: 1670 TTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFA 1825
T IVIAHRLST++NA+ I V++AG+++E G+H L+ + G+Y +L Q A
Sbjct: 1268 TCIVIAHRLSTIQNANVICVIQAGKIVEQGSHSQLLAKNGIYSKLYRCQTKA 1319
Score = 325 bits (833), Expect = 5e-87
Identities = 208/555 (37%), Positives = 297/555 (53%), Gaps = 10/555 (1%)
Frame = +2
Query: 2144 IINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRN 2323
+ N + +++KD + ++ + + S ++ F A +LT+R+R + ++
Sbjct: 106 LTNASYEENMQELRKDSVSFGILMTLNTLLMLFSGVYYVDAFNRLALKLTVRMRREFFKA 165
Query: 2324 VLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGW 2503
LRQ+ + DM K R+ + I+S I LG + V + ++F YGW
Sbjct: 166 TLRQEIGWHDMAKDQ--NFAVRITDNMEKIRSGIAENLGHYVEIMCDVIISVVLSFIYGW 223
Query: 2504 QMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTK 2683
++A ++ P V + + Y G + A E I IRTV A +
Sbjct: 224 KLALAIVFYIPLTLVVNSAVAHYQGKLTGQEQSSYVRASSVVEEVIGAIRTVVAFGGERS 283
Query: 2684 LYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIF---DKNVLME 2854
+ S L K GL+ ++ F T A +F +G LI D ++ ++
Sbjct: 284 ESLRYDSLLKPALKAGKWKGAFSGLSDTVMKAMLFITGAGSFWYGANLILYYRDPSIPID 343
Query: 2855 -----PENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSG 3019
P V+ V+ I S I + + + A +A I ++++ ID ++ +G
Sbjct: 344 EREYTPAVVMIVISGIIVSANQISRTSPFLETFAMARGSASAILDVIDRTSLIDPLSKAG 403
Query: 3020 TYPQ--LSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLE 3193
L G V+ VFFRYP R V +L+GLNV V+ GQT+ALVGPSGCGKST I LL+
Sbjct: 404 KILNYGLKGAVEFRDVFFRYPAREDVIVLRGLNVVVEEGQTVALVGPSGCGKSTCIQLLQ 463
Query: 3194 RLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQ 3373
R YDP+ G V +D D+R+ N K LR +IA+V QEP+LF SI ENI +G E T ++
Sbjct: 464 RFYDPVFGQVLLDGEDVRKYNIKWLRSNIAVVGQEPVLFQGSIGENIRHGKP--EATQKE 521
Query: 3374 IETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATS 3553
+E A AN H FI L GY+T + EKG QLSGGQ+QRIAIARALI+ PKILLLDEATS
Sbjct: 522 VEDAAKAANAHDFIIALHKGYDTDISEKGVQLSGGQRQRIAIARALIQQPKILLLDEATS 581
Query: 3554 ALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKR 3733
ALD SEK VQ ALD A K RT +VV+HRLS I +A I+ ++NG+ VEQGTH EL+
Sbjct: 582 ALDYHSEKLVQAALDKACKGRTTLVVSHRLSAIRHAHRIVYIENGKAVEQGTHEELMKLE 641
Query: 3734 GAYFALTQKQSSNQS 3778
G Y + S + S
Sbjct: 642 GFYHKMVTVHSYDDS 656
>gi|15232978|ref|NP_189480.1| P-glycoprotein, putative [Arabidopsis
thaliana]
gi|9294574|dbj|BAB02855.1| multidrug resistance p-glycoprotein; ABC
transporter-like protein [Arabidopsis thaliana]
Length = 1225
Score = 731 bits (1886), Expect = 0.0
Identities = 442/1250 (35%), Positives = 683/1250 (54%), Gaps = 10/1250 (0%)
Frame = +2
Query: 44 SIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTAS 223
SI ++ + VD +++A+G+I + G P++ I + N G+ F D
Sbjct: 7 SIRSIFMHADGVDWMLMALGLIGAVGDGFITPIIFFICSKLLNNVG--GSSFDDET---- 60
Query: 224 EKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQ 403
F V +N + VY+ C + F++ C+ E+ + + R ++ +V+RQ
Sbjct: 61 --------FMQTVAKNAVALVYVACASWVICFIEGYCWTRTGERQAAKMREKYLKAVLRQ 112
Query: 404 EIAWYD---KNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLT 574
++ ++D +TS +++ D+L +++ +K+ + F+ + V F W LT
Sbjct: 113 DVGYFDLHVTSTSDVITSVSSDSLV-IQDFLSEKLPNFLMNTSAFVASYIVGFLLLWRLT 171
Query: 575 LIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECK 754
++ ++I GL +Y AG IAE+V++S+RTV AF ++ +
Sbjct: 172 IVGFPFIILLLIPGLMYGRALIRISMKIREEYNEAGSIAEQVISSVRTVYAFGSEKKMIE 231
Query: 755 RYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVF 934
++ AL+ K G+++ G + S I YA + W G+ V + + GTV +V
Sbjct: 232 KFSTALQGSVKLGLRQGLAKGIAIGSNG-ITYAIWGFLTWYGSRMVMNHGSKGGTVSSVI 290
Query: 935 FSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVN 1114
V G +LGQ+ A + +VI+R+P ID+ + EGQ K G + N
Sbjct: 291 VCVTFGGTSLGQSLSNLKYFSEAFVVGERIMKVINRVPGIDSDNLEGQILEKTRGEVEFN 350
Query: 1115 KVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDD 1294
V+FTYP+R + I + L G+TVALVG SG GKST+I LLQRFY+P AG+ILID
Sbjct: 351 HVKFTYPSRPETPIFDDLCLRVPSGKTVALVGGSGSGKSTVISLLQRFYDPIAGEILIDG 410
Query: 1295 IPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKT 1474
+PI +K+LR +G+VSQEP LF TSI++NI +G+ D S +++ A K +NA FI
Sbjct: 411 LPINKLQVKWLRSQMGLVSQEPVLFATSIKENILFGKEDASMDEVVEAAKASNAHSFISQ 470
Query: 1475 FPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALEN 1654
FP T VG+RGVQ+SGGQKQRIAIARA++++P ILLLDEATSALD+ESE +VQ AL+N
Sbjct: 471 FPNSYQTQVGERGVQLSGGQKQRIAIARAIIKSPIILLLDEATSALDSESERVVQEALDN 530
Query: 1655 ASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQ-KGLYHELVHAQVFADV 1831
AS GRTTIVIAHRLST+RNAD I V+ G+++E G+HE L+E+ G Y LV Q
Sbjct: 531 ASIGRTTIVIAHRLSTIRNADVICVVHNGRIIETGSHEELLEKLDGQYTSLVRLQ----- 585
Query: 1832 DDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXX 2011
+ + + S S +G + +++ +
Sbjct: 586 -------QVDNKESDHISVEEGQASSLSKD--LKYSPKEFIHSTSSNIVRDFPNLSPKDG 636
Query: 2012 GAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKD 2191
++ + +++ RPEW + + GAV P +S +++V+ DQ+K+
Sbjct: 637 KSLVPSFKRLMSMNRPEWKHALYGCLGAALFGAVQPIYSYSSGSMVSVYFLASHDQIKEK 696
Query: 2192 GHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSP 2371
+ L+F+ LA S + Q F E LT RIR ++ +L + +FD ++S
Sbjct: 697 TRIYVLLFVGLALFTFLSNISQHYGFAYMGEYLTKRIRERMLGKILTFEVNWFDKDENSS 756
Query: 2372 GRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAV- 2548
G I +RLA DA ++S + R+ + I++V I W+ + ++M++ P + V
Sbjct: 757 GAICSRLAKDANMVRSLVGDRMSLLVQTISAVSITCAIGLVISWRFSIVMMSVQPVIVVC 816
Query: 2549 --GQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPH 2722
Q +++K +A K + + K A EA+ NIRT+ A + Q ++ N+ + P
Sbjct: 817 FYTQRVLLKSMSRNA---IKGQDESSKLAAEAVSNIRTITAFSSQERIINLLKMVQEGPR 873
Query: 2723 GGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFG 2902
+ ++ + G+ G + S+ A F +G LI D M + L + + +
Sbjct: 874 KDSARQSWLAGIMLGTSQSLITCVSALNFWYGGKLIADGK--MMSKEFLEIFLIFASTGR 931
Query: 2903 TIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYP-QLSGEVKLNKVFFRYPE 3079
I A + + +K + A +F +L+ I+ G P ++ G++ + V F YP
Sbjct: 932 VIAEAGTMTKDLVKGSDAVASVFAVLDRNTTIEPENPDGYVPKKVKGQISFSNVDFAYPT 991
Query: 3080 RPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNP 3259
RP V I Q ++ ++ G++ A+VGPSG GKST+ISL+ER YDPL+G V +D D+R +
Sbjct: 992 RPDVIIFQNFSIDIEDGKSTAIVGPSGSGKSTIISLIERFYDPLKGIVKIDGRDIRSCHL 1051
Query: 3260 KHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYE 3439
+ LR+HIALVSQEP LF +IRENI+YG + +I A AN H FI L +GY+
Sbjct: 1052 RSLRQHIALVSQEPTLFAGTIRENIMYGGASNKIDESEIIEAAKAANAHDFITSLSNGYD 1111
Query: 3440 TRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRT 3619
T G++G QLSGGQKQRIAIARA+++NP +LLLDEATSALD++SE VQ AL+ RT
Sbjct: 1112 TCCGDRGVQLSGGQKQRIAIARAVLKNPSVLLLDEATSALDSQSESVVQDALERLMVGRT 1171
Query: 3620 CIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAK--RGAYFALTQKQ 3763
+V+AHRLSTI I V++NG VVE G H+ L+AK +GAYF+L Q
Sbjct: 1172 SVVIAHRLSTIQKCDTIAVLENGAVVECGNHSSLLAKGPKGAYFSLVSLQ 1221
Score = 308 bits (789), Expect = 7e-82
Identities = 193/531 (36%), Positives = 293/531 (54%), Gaps = 12/531 (2%)
Frame = +2
Query: 2282 ERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIA 2461
ER ++R K + VLRQD YFD+ S + T +++D+ I+ + +L + +
Sbjct: 95 ERQAAKMREKYLKAVLRQDVGYFDLHVTSTSDVITSVSSDSLVIQDFLSEKLPNFLMNTS 154
Query: 2462 SVGGGLGIAFYYGWQMA-----FLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKT 2626
+ + F W++ F+++ + P + G+AL+ + +E AG
Sbjct: 155 AFVASYIVGFLLLWRLTIVGFPFIILLLIPGLMYGRALIR-----ISMKIREEYNEAGSI 209
Query: 2627 AMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAA 2806
A + I ++RTV A + K+ F + L G++ + +GL G A TYA
Sbjct: 210 AEQVISSVRTVYAFGSEKKMIEKFSTALQ----GSVKLGLRQGLAKGIAIGSNGITYAI- 264
Query: 2807 FRFGLFLIFDKNVLMEPEN----VLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFN 2974
+G + ++M + V V+ ++F ++G + S + +A I
Sbjct: 265 --WGFLTWYGSRMVMNHGSKGGTVSSVIVCVTFGGTSLGQSLSNLKYFSEAFVVGERIMK 322
Query: 2975 MLEEEPRIDGMTSSGTYPQLS-GEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVG 3151
++ P ID G + + GEV+ N V F YP RP PI L + V G+T+ALVG
Sbjct: 323 VINRVPGIDSDNLEGQILEKTRGEVEFNHVKFTYPSRPETPIFDDLCLRVPSGKTVALVG 382
Query: 3152 PSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIREN 3331
SG GKSTVISLL+R YDP+ G + +D + ++ K LR + LVSQEP+LF TSI+EN
Sbjct: 383 GSGSGKSTVISLLQRFYDPIAGEILIDGLPINKLQVKWLRSQMGLVSQEPVLFATSIKEN 442
Query: 3332 IVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARAL 3511
I++G + + + +++ A +N H FI + P+ Y+T+VGE+G QLSGGQKQRIAIARA+
Sbjct: 443 ILFGKE--DASMDEVVEAAKASNAHSFISQFPNSYQTQVGERGVQLSGGQKQRIAIARAI 500
Query: 3512 IRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQ 3691
I++P ILLLDEATSALD+ESE+ VQ ALD A+ RT IV+AHRLSTI NA I VV NG+
Sbjct: 501 IKSPIILLLDEATSALDSESERVVQEALDNASIGRTTIVIAHRLSTIRNADVICVVHNGR 560
Query: 3692 VVEQGTHNELIAK-RGAYFALTQ-KQSSNQSGGAFDTSEALXXXXXXHVKF 3838
++E G+H EL+ K G Y +L + +Q N+ E +K+
Sbjct: 561 IIETGSHEELLEKLDGQYTSLVRLQQVDNKESDHISVEEGQASSLSKDLKY 611
>gi|38049160|gb|AAR10387.1| P-glycoprotein 1 [Sorghum bicolor]
Length = 1402
Score = 730 bits (1885), Expect = 0.0
Identities = 431/1257 (34%), Positives = 672/1257 (53%), Gaps = 21/1257 (1%)
Frame = +2
Query: 56 LYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAA 235
L+R+ +D ++ VG + + G LP+ ++ +F G+ DP++
Sbjct: 131 LFRFADGLDCALMLVGTLGALVHGCSLPVFLRFFADLVDSF---GSHANDPDTMV----- 182
Query: 236 ARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAW 415
V++ ++ +G I+A+ + + SC+M E+ S R R ++ + +RQ++++
Sbjct: 183 ------RLVVKYAFYFLVVGAAIWASSWAEISCWMWTGERQSTRMRIRYLDAALRQDVSF 236
Query: 416 YDKNT-SGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSL 592
+D + + + + + V++ +K+G MA F+ GF V FT W L L+ +++
Sbjct: 237 FDTDVRTSDVIYAINADAVVVQDAISEKLGNLIHYMATFVAGFVVGFTAAWQLALVTLAV 296
Query: 593 SPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDAL 772
P + + G + A GIAE+ L IR V AF G+E E + Y AL
Sbjct: 297 VPLIAVIGGLSAAALAKLSSRSQDALSGASGIAEQALAQIRIVQAFVGEEREMRAYSAAL 356
Query: 773 EHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMG 952
+K G + F G GL + ++ Y L W G + V G + FSVM+G
Sbjct: 357 AVAQKIGYRSGFAKGLGLGGTYFTVFCCYGLLLWYGGHLVRGHHTNGGLAIATMFSVMIG 416
Query: 953 SMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTE---GQTPSKISGRISVNKVE 1123
+ALGQ+ A A AAA ++ +ID P I + E G ++GR+ + V+
Sbjct: 417 GLALGQSAPSMAAFAKARVAAAKIFRIIDHRPGISSRDGEDGGGVELESVTGRVEMRGVD 476
Query: 1124 FTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPI 1303
F YP+R DV IL+G SL G+T+ALVGSSG GKST++ LL+RFY+P AGQIL+D +
Sbjct: 477 FAYPSRPDVPILRGFSLSVPAGKTIALVGSSGSGKSTVVSLLERFYDPSAGQILLDGHDL 536
Query: 1304 EDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVS--DEDIARALKEANAADFIKTF 1477
+ +++LRQ +G+VSQEP LF TSI++N+ GR S ++ A + ANA FI
Sbjct: 537 KSLKLRWLRQQIGLVSQEPTLFATSIKENLLLGRDSQSATQAEMEEAARVANAHSFIVKL 596
Query: 1478 PEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENA 1657
P+G +T VG+RG+Q+SGGQKQRIAIARA+++NP ILLLDEATSALD+ESE +VQ AL+
Sbjct: 597 PDGYDTQVGERGLQLSGGQKQRIAIARAMLKNPAILLLDEATSALDSESEKLVQEALDRF 656
Query: 1658 SRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIE--QKGLY------HELVHA 1813
GRTT+VIAHR+ST+R AD + V++ G V E+G H+ L+ + G Y E H
Sbjct: 657 MIGRTTLVIAHRMSTIRKADVVAVLQGGPVSEMGAHDELMAKGENGTYAKFIRMQEQAHE 716
Query: 1814 QVFADVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXX 1993
F + + + R + S ++ S+
Sbjct: 717 AAFVNARRSSARPSSARNSVSSPIMTRNSSYGRSPYSRRLSDFSTSDFTLSIHDPHHHHR 776
Query: 1994 XXXXXXGAVKANLFKILRYAR---PEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSN 2164
A +A LR AR PEW Y ++ G+ F+ S +++V+
Sbjct: 777 TMADKQLAFRAGASSFLRLARMNSPEWAYALVGSLGSMVCGSFSAIFAYILSAVLSVYYA 836
Query: 2165 PDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDAT 2344
PD MK++ + + + +++ Q + E LT R+R K++ VLR +
Sbjct: 837 PDPRYMKREIAKYCYLLIGMSSAALLFNTVQHVFWDTVGENLTKRVREKMFAAVLRNEIA 896
Query: 2345 YFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVM 2524
+FD +++ R+ RLA DA N++SAI R+ I A + F W++A +++
Sbjct: 897 WFDADENASARVAARLALDAQNVRSAIGDRISVIVQNSALMLVACTAGFVLQWRLALVLL 956
Query: 2525 AIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCS 2704
A+FP + L + G + A + A EA+ N+RTV A + K+ +F +
Sbjct: 957 AVFPLVVAATVLQKMFMKGFSGDLEAAHARATQIAGEAVANLRTVAAFNAERKITGLFEA 1016
Query: 2705 HLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFA 2884
+L P K I G YG A + + +YA + +L+ K+ + + +RV
Sbjct: 1017 NLRGPLRRCFWKGQIAGSGYGVAQFLLYASYALGLWYAAWLV--KHGVSDFSRTIRVFMV 1074
Query: 2885 ISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRI--DGMTSSGTYPQLSGEVKLNK 3058
+ S + P+++K A +F ++ + + D + ++ + GEV+L
Sbjct: 1075 LMVSANGAAETLTLAPDFVKGGRAMRSVFETIDRKTEVEPDDVDAAPVPERPKGEVELKH 1134
Query: 3059 VFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNN 3238
V F YP RP + + + L++ + G+TLALVGPSGCGKS+V++L++R Y+P G V +D
Sbjct: 1135 VDFSYPSRPDIQVFRDLSLRARAGKTLALVGPSGCGKSSVLALVQRFYEPTSGRVLLDGK 1194
Query: 3239 DLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFID 3418
D+R+ N + LR+ +A+ QEP LF SI +NI YG + T ++ A ++AN H+FI
Sbjct: 1195 DVRKYNLRALRRVVAVAPQEPFLFAASIHDNIAYGREGA--TEAEVVEAATQANAHRFIA 1252
Query: 3419 ELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALD 3598
LP+GY T+VGE+G QLSGGQ+QRIAIARAL++ I+LLDEATSALD ESE+ VQ AL+
Sbjct: 1253 ALPEGYGTQVGERGVQLSGGQRQRIAIARALVKQAAIVLLDEATSALDAESERCVQEALE 1312
Query: 3599 AAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKR--GAYFALTQKQ 3763
A RT IVVAHRL+T+ A I V+ +G+V EQG+H+ L+ G Y + Q Q
Sbjct: 1313 RAGSGRTTIVVAHRLATVRGAHTIAVIDDGKVAEQGSHSHLLKHHPDGCYARMLQLQ 1369
>gi|45735908|dbj|BAD12940.1| putative P-glycoprotein 1 [Oryza sativa
(japonica cultivar-group)]
Length = 1344
Score = 729 bits (1883), Expect = 0.0
Identities = 433/1257 (34%), Positives = 671/1257 (52%), Gaps = 15/1257 (1%)
Frame = +2
Query: 53 QLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKA 232
QL+ + +D +++ +G + + G LP+ ++ +F A
Sbjct: 97 QLFSFADGLDYVLMTLGTLGALVHGCSLPVFLRFFADLVDSF--------------GSHA 142
Query: 233 AARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIA 412
A V++ ++ +G I+A+ + + SC+M E+ S R R ++ H+ + Q+++
Sbjct: 143 AHPDTMLRLVVKYAFYFLVVGAAIWASSWAEISCWMWTGERQSTRMRIRYLHAALHQDVS 202
Query: 413 WYDKNT-SGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMS 589
++D + + + + + + V++ +K+G +A F+ GF V FT W L L+ ++
Sbjct: 203 FFDTDVRTSDVIHAINADAVVVQDAISEKLGNLIHYLATFVSGFVVGFTAAWQLALVTLA 262
Query: 590 LSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDA 769
+ P + + G + A GIAE+ L IR V +F G+E + Y A
Sbjct: 263 VVPLIAVIGGLSAAALAKLSSRSQDALSDASGIAEQALAQIRIVQSFVGEERVMRAYSAA 322
Query: 770 LEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMM 949
L ++ G + F G GL + ++ Y L W G + V G + FSVM+
Sbjct: 323 LAVAQRIGYRSGFAKGIGLGGTYFTVFCCYALLLWYGGHLVRRAHTNGGLAIATMFSVMI 382
Query: 950 GSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFT 1129
G +ALGQ+ A A AAA ++ +++ P ++ G ++GR+ + VEF+
Sbjct: 383 GGLALGQSAPSMAAFAKARVAAAKIFRMMEHKPSMEREG--GVELEAVTGRVELRDVEFS 440
Query: 1130 YPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIED 1309
YP+R DV IL+G+SL G+T+ALVGSSG GKST++ L++RFY P+AG IL+D + D
Sbjct: 441 YPSRPDVGILRGLSLSVPAGKTIALVGSSGSGKSTVVSLIERFYEPNAGTILLDGHDLRD 500
Query: 1310 FNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEGL 1489
N+++LR+ +G+VSQEP LF T+I +N+ GR + E++ A + ANA FI P+
Sbjct: 501 LNLRWLRRQIGLVSQEPALFATTIRENLLLGRDGATQEELEEAARVANAHSFIVKLPDAY 560
Query: 1490 NTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGR 1669
NT VG+RG+Q+SGGQKQRIAIARA++RNP ILLLDEATSALD+ESE +VQ AL+ GR
Sbjct: 561 NTQVGERGLQLSGGQKQRIAIARAMLRNPAILLLDEATSALDSESEKLVQEALDRFMIGR 620
Query: 1670 TTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQ-KGLYHELVHAQVFADVDDKPK 1846
TT+VIAHRLST+R AD + V++ G + EVGTH+ L+ + G Y L+ Q A
Sbjct: 621 TTLVIAHRLSTIRKADLVAVLQGGAISEVGTHDELMARGDGTYARLIRMQEQA----HEA 676
Query: 1847 KKEAERRMSRQTSQRKGSV-------NFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXX 2005
A RR S + S + SV N S
Sbjct: 677 ALVAARRSSARPSSARNSVSSPIITRNSSYGRSPYSRRLSDADFITGLGLGVDSKQQQQQ 736
Query: 2006 XXGAVKANLF-KILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQM 2182
V+A+ F ++ + PEW Y ++ G+ F+ S +++V+ PD M
Sbjct: 737 HYFRVQASSFWRLAKMNSPEWGYALVASLGSMVCGSFSAIFAYVLSAVLSVYYAPDAAYM 796
Query: 2183 KKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPK 2362
+ + + + +++ Q + E LT R+R ++ VLR + +FDM
Sbjct: 797 DRQIAKYCYLLIGMSSAALLFNTVQHLFWDTVGENLTKRVRERMLAAVLRNEIAWFDMED 856
Query: 2363 HSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFM 2542
+S RI RLA DA N++SAI R+ I A + F W++A +++A+FP +
Sbjct: 857 NSSARIAARLALDAQNVRSAIGDRISIIVQNSALMLVACTAGFVLQWRLALVLLAVFPLV 916
Query: 2543 AVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPH 2722
L + G + + A + A EA+ N+RTV A + K+ +F ++L P
Sbjct: 917 VAATVLQKMFLKGFSGDLERAHARATQIAGEAVANVRTVAAFGSEAKIVGLFEANLAGPL 976
Query: 2723 GGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFG 2902
K I G YG A + + +YA + +L+ K+ + + +RV + S
Sbjct: 977 RRCFWKGQIAGSGYGVAQFLLYASYALGLWYAAWLV--KHGVSDFSKTIRVFMVLMVSAN 1034
Query: 2903 TIGFAASYFPEYIKATFAAGLIFNMLEEEPRI--DGMTSSGTYPQLSGEVKLNKVFFRYP 3076
+ P+++K A +F ++ I D + ++ + GEV+L V F YP
Sbjct: 1035 GAAETLTLAPDFVKGGRAMQAVFEAMDRRTEIEPDDVDAAAVPERPRGEVELKHVDFAYP 1094
Query: 3077 ERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMN 3256
RP V + + L++ + G+TLALVG SGCGKS+V++L++R Y+P G V +D DLR+ N
Sbjct: 1095 SRPEVQVFRDLSLRARAGRTLALVGASGCGKSSVLALVQRFYEPNSGRVLLDGRDLRKFN 1154
Query: 3257 PKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGY 3436
+ LR+ +ALV QEP LF +I +NI YG + T ++ A + AN HKFI LP+GY
Sbjct: 1155 LRSLRRAMALVPQEPFLFAATIHDNIAYGREGA--TEAEVVEAATAANAHKFISALPEGY 1212
Query: 3437 ETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVAL-DAAAKD 3613
T VGE+G QLSGGQ+QRIAIARAL++ ILLLDEATSALD ESE+ VQ AL ++
Sbjct: 1213 GTLVGERGVQLSGGQRQRIAIARALVKQAPILLLDEATSALDAESERSVQEALASSSGSG 1272
Query: 3614 RTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKR--GAYFALTQKQSSNQS 3778
RT IVVAHRL+T+ NA I V+ +G+V EQG+H+ L+ G Y + Q Q + S
Sbjct: 1273 RTTIVVAHRLATVRNAHTIAVIDDGKVAEQGSHSHLLNHHPDGCYARMLQLQRLSHS 1329
>gi|21740907|emb|CAD40903.1| OSJNBa0036B21.21 [Oryza sativa (japonica
cultivar-group)]
Length = 1252
Score = 725 bits (1871), Expect = 0.0
Identities = 428/1259 (33%), Positives = 661/1259 (51%), Gaps = 18/1259 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
++ +L+ + +D L++A G + G +P+ ++ G + F
Sbjct: 29 VAFHELFGFADPLDWLLMAAGSAGAVVHGAAMPVFFLLFGELINGF-------------- 74
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
+ + + EV + Q +C+M E+ RR++ +V+R
Sbjct: 75 GKNQHSLRRMTDEVSK-----------------AQIACWMYTGERQVGALRRRYLEAVLR 117
Query: 401 QEIAWYDKNT-SGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
Q++ ++D + +G + + + V++ G+KVG ++ F+ G V F W L L
Sbjct: 118 QDVGFFDTDARTGDVVFSVSTDTLLVQDAIGEKVGNFIHYLSTFLAGLVVGFVSAWRLAL 177
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
+ +++ P + G YA AG IAE+ + +RTV ++ G+
Sbjct: 178 LSIAVIPGIAFAGGLYAYTLTGLTSKSRDSYANAGIIAEQAIAQVRTVYSYVGESKALNS 237
Query: 758 YEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFF 937
Y +A+++ K G K G G+ + I S+ L FW F+ +G+ + G T F
Sbjct: 238 YSEAIQNTLKLGYKAGMAKGLGIGCTYGIACMSWALVFWYAGVFIRNGQTDGGKAFTAIF 297
Query: 938 SVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNK 1117
S ++G ++LGQ+ A L EVI + P I +G+ ++ G I +
Sbjct: 298 SAIVGGLSLGQSFSNLGAFSKGKIAGYKLLEVIRQRPTIVQDPADGRCLDEVHGNIEFKE 357
Query: 1118 VEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDI 1297
V F+YP+R DV I + SL G+T A+VG SG GKST++ L++RFY+P+ GQ+L+D++
Sbjct: 358 VAFSYPSRPDVMIFRDFSLFFPAGKTAAVVGGSGSGKSTVVALIERFYDPNQGQVLLDNV 417
Query: 1298 PIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTF 1477
I+ +K+LR +G+V+QEP LF T+I +NI YG+ D + ++ A ANA FI
Sbjct: 418 DIKTLQLKWLRDQIGLVNQEPALFATTILENILYGKPDATMAEVEAAATSANAHSFIALL 477
Query: 1478 PEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENA 1657
P G NT VG+RG+Q+SGGQKQRIAIARA+++NPKILLLDEATSALDA SE+IVQ AL+
Sbjct: 478 PNGYNTQVGERGLQLSGGQKQRIAIARAMLKNPKILLLDEATSALDAGSENIVQEALDRL 537
Query: 1658 SRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQ--KGLYHELVHAQVFA-- 1825
GRTT+V+AHRLST+R D I V++ GQV+E GTH+ L+ + G Y L+ Q A
Sbjct: 538 MVGRTTVVVAHRLSTIRCVDMIAVIQQGQVVETGTHDELLAKGSSGAYAALIRFQEMARN 597
Query: 1826 -DVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXX 2002
D +K R+S S R S+ + +
Sbjct: 598 RDFRGPSTRKSRSSRLSNSLSTRSLSL----RSGSLRNLSYSYSTGADGRIEMVSNADND 653
Query: 2003 XXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQM 2182
A K FK+L+ PEW Y ++ G + P F++ S +I VF D + M
Sbjct: 654 RKYPAPKGYFFKLLKLNAPEWPYTILGAIGSILSGFIGPTFAIVMSNMIEVFYFRDPNAM 713
Query: 2183 KKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIR----------SKVYRNVLR 2332
++ + +++ + L Q F + E LT R+R +++ +LR
Sbjct: 714 ERKTREYVFIYIGTGLYAVVAYLVQHYFFSIMGENLTTRVRRMMLAVALFDQRLFSAILR 773
Query: 2333 QDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMA 2512
D +FD +++ + RL+TDA ++KSAI R+ I + S+ + F W++A
Sbjct: 774 NDVGWFDQEENNSSLVAARLSTDAADVKSAIAERISVILQNMTSLLVSFVVGFIIEWRVA 833
Query: 2513 FLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYN 2692
L++ FP + + G A AK A E + NIRTV A Q K+ +
Sbjct: 834 VLILVTFPLLVLANFAQQLSMKGFAGDTAKAHAKTSMIAGEGVSNIRTVAAFNAQDKVLS 893
Query: 2693 IFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLR 2872
+FC+ L P ++ ++ I G +G + + + A +G L+ ++ + V++
Sbjct: 894 LFCTELRVPQMHSLRRSQISGALFGLSQLSLYASEALILWYGAHLV--RHHVSTFSKVIK 951
Query: 2873 VLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRID-GMTSSGTYPQLSGEVK 3049
V + + T+ S PE ++ + +F +L RID + + G++
Sbjct: 952 VFVVLVITANTVAETVSLAPEIVRGGESIRSVFAILNYRTRIDPDEPETEPVESVRGDID 1011
Query: 3050 LNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTV 3229
V F YP RP V + + ++ ++ GQ+ ALVG SG GKSTVI+L+ER YDPL G V +
Sbjct: 1012 FRHVDFAYPSRPDVMVFKDFSLRIRAGQSQALVGASGSGKSTVIALIERFYDPLAGKVMI 1071
Query: 3230 DNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHK 3409
D D+R++N + LR I LV QEP+LF TSI ENI YG T E++ A AN+H
Sbjct: 1072 DGKDIRRLNVRSLRLKIGLVQQEPVLFATSIFENIAYGKDGA--TEEEVIEAAKVANMHG 1129
Query: 3410 FIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQV 3589
F+ LP+GY+T VGE+G QLSGGQKQRIAIARA++++P +LLLDEATSALD ESE +Q
Sbjct: 1130 FVSALPEGYKTPVGERGVQLSGGQKQRIAIARAVLKDPAVLLLDEATSALDAESECVLQE 1189
Query: 3590 ALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAK-RGAYFALTQKQ 3763
AL+ K RT ++VAHRLSTI I VV++G+VVEQG+H EL+++ GAY L Q Q
Sbjct: 1190 ALERIMKGRTAVLVAHRLSTIRGVDSIAVVQDGRVVEQGSHGELVSRPDGAYSRLLQLQ 1248
>gi|9294577|dbj|BAB02858.1| multidrug resistance p-glycoprotein; ABC
transporter-like protein [Arabidopsis thaliana]
Length = 1262
Score = 723 bits (1867), Expect = 0.0
Identities = 434/1251 (34%), Positives = 677/1251 (53%), Gaps = 11/1251 (0%)
Frame = +2
Query: 44 SIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTAS 223
S+ ++ + ++VD +++ +G+I + G P++ I G + + +S+
Sbjct: 39 SVRSIFMHANSVDLVLMGLGLIGAVGDGFITPIIFFITGLLLNDI---------GDSSFG 89
Query: 224 EKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQ 403
+K F H +++N + +Y+ F++ C+ E+ ++R R ++ +V+RQ
Sbjct: 90 DKT-----FMHAIMKNAVALLYVAGASLVICFVEGYCWTRTGERQASRMREKYLRAVLRQ 144
Query: 404 EIAWYD---KNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLT 574
++ ++D +TS +++ D L +++ +K+ + F+ + V F W LT
Sbjct: 145 DVGYFDLHVTSTSDVITSVSSDTLV-IQDVLSEKLPNFLMSASAFVASYIVGFIMLWRLT 203
Query: 575 LIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECK 754
++ ++I GL +Y AG IAE+ ++ +RTV AF +
Sbjct: 204 IVGFPFFILLLIPGLMCGRALINISRKIREEYNEAGSIAEQAISLVRTVYAFGSERKMIS 263
Query: 755 RYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVF 934
++ ALE K G+++ G + S V YA + W G+ V + GT+ V
Sbjct: 264 KFSAALEGSVKLGLRQGIAKGIAIGSNGVT-YAIWGFMTWYGSRMVMYHGAKGGTIFAVI 322
Query: 935 FSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVN 1114
+ G +LG+ A+ A + EVI R+P+ID+ + GQ I G +
Sbjct: 323 ICITYGGTSLGRGLSNLKYFSEAVVAGERIIEVIKRVPDIDSDNPRGQVLENIKGEVQFK 382
Query: 1115 KVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDD 1294
V+F Y +R + I + L G++VALVG SG GKST+I LLQRFY+P G+ILID
Sbjct: 383 HVKFMYSSRPETPIFDDLCLRIPSGKSVALVGGSGSGKSTVISLLQRFYDPIVGEILIDG 442
Query: 1295 IPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKT 1474
+ I+ +K+LR +G+VSQEP LF TSIE+NI +G+ D S +++ A K +NA DFI
Sbjct: 443 VSIKKLQVKWLRSQMGLVSQEPALFATSIEENILFGKEDASFDEVVEAAKSSNAHDFISQ 502
Query: 1475 FPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALEN 1654
FP G T VG+RGVQMSGGQKQRI+IARA++++P +LLLDEATSALD+ESE +VQ AL+N
Sbjct: 503 FPLGYKTQVGERGVQMSGGQKQRISIARAIIKSPTLLLLDEATSALDSESERVVQEALDN 562
Query: 1655 ASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQ-KGLYHELVHAQVFADV 1831
A+ GRTTIVIAHRLST+RN D I V K GQ++E G+HE L+E G Y LV Q+
Sbjct: 563 ATIGRTTIVIAHRLSTIRNVDVICVFKNGQIVETGSHEELMENVDGQYTSLVRLQIM--- 619
Query: 1832 DDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXX 2011
+ +E+ +S S R+G + ++ +
Sbjct: 620 ----ENEESNDNVS--VSMREGQFSNFNKDVKYSSRLSIQSRSSLFATSSIDTNLAGSIP 673
Query: 2012 GAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKD 2191
K + +++ +PEW + ++ GA+ P ++ +++V+ D+MK+
Sbjct: 674 KDKKPSFKRLMAMNKPEWKHALYGCLSAVLYGALHPIYAYASGSMVSVYFLTSHDEMKEK 733
Query: 2192 GHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSP 2371
+ L+F+ LA + + Q F E LT RIR + +L + ++FD ++S
Sbjct: 734 TRIYVLLFVGLAVLCFLISIIQQYSFAYMGEYLTKRIRENILSKLLTFEVSWFDEDENSS 793
Query: 2372 GRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVG 2551
G I +RLA DA ++S + R+ + I++V + W+++ +++AI P + VG
Sbjct: 794 GSICSRLAKDANVVRSLVGERVSLLVQTISAVSVACTLGLAISWKLSIVMIAIQP-VVVG 852
Query: 2552 ----QALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAP 2719
Q +++K A K + + K A EA+ NIRT+ A + Q ++ + + P
Sbjct: 853 CFYTQRIVLKSISKKA---IKAQDESSKLAAEAVSNIRTITAFSSQERILKLLKMVQEGP 909
Query: 2720 HGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSF 2899
NI ++ + G+ + S+ T A + +G LI D + + L +LF +
Sbjct: 910 QRENIRQSWLAGIVLATSRSLMTCTSALNYWYGARLIIDGKITSKAFFELFILFVSTGR- 968
Query: 2900 GTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKLNKVFFRYP 3076
I A + + K + A G +F +L+ I+ G PQ + G++K V F YP
Sbjct: 969 -VIADAGAMTMDLAKGSDAVGSVFAVLDRYTNIEPEKPDGFVPQNIKGQIKFVNVDFAYP 1027
Query: 3077 ERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMN 3256
RP V I + ++ + G++ A+VGPSG GKST+I L+ER YDPL+G V +D D+R +
Sbjct: 1028 TRPDVIIFKNFSIDIDEGKSTAIVGPSGSGKSTIIGLIERFYDPLKGIVKIDGRDIRSYH 1087
Query: 3257 PKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGY 3436
+ LR+HI LVSQEPILF +IRENI+YG + +I A AN H FI L DGY
Sbjct: 1088 LRSLRQHIGLVSQEPILFAGTIRENIMYGGASDKIDESEIIEAAKAANAHDFIVTLSDGY 1147
Query: 3437 ETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDR 3616
+T G++G QLSGGQKQRIAIARA+++NP +LLLDEATSALD +SE+ VQ AL R
Sbjct: 1148 DTYCGDRGVQLSGGQKQRIAIARAVLKNPSVLLLDEATSALDNQSERMVQDALGRLMVGR 1207
Query: 3617 TCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAK--RGAYFALTQKQ 3763
T +V+AHRLSTI N I V+ G+VVE GTH+ L+AK G YF+L Q
Sbjct: 1208 TSVVIAHRLSTIQNCDTITVLDKGKVVECGTHSSLLAKGPTGVYFSLVSLQ 1258
>gi|15229473|ref|NP_189475.1| ABC transporter family protein
[Arabidopsis thaliana]
Length = 1240
Score = 723 bits (1865), Expect = 0.0
Identities = 440/1262 (34%), Positives = 679/1262 (52%), Gaps = 19/1262 (1%)
Frame = +2
Query: 44 SIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTAS 223
S+ ++ + VD L++ +G+I + G PL+ +I + N +G + ++
Sbjct: 19 SVRSIFMHADGVDWLLMGLGLIGAVGDGFTTPLVLLITSKLMNN---IGGSSFNTDT--- 72
Query: 224 EKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQ 403
F + +N + +Y+ CG + FL+ C+ E+ + R R ++ +V+RQ
Sbjct: 73 --------FMQSISKNSVALLYVACGSWVVCFLEGYCWTRTGERQTARMREKYLRAVLRQ 124
Query: 404 EIAWYD---KNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLT 574
++ ++D +TS +++ D+ +++ +K+ + F+G + V F W L
Sbjct: 125 DVGYFDLHVTSTSDVITSVSSDSFV-IQDVLSEKLPNFLMSASTFVGSYIVGFILLWRLA 183
Query: 575 LIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECK 754
++ + ++I GL +Y AG +AE+ ++S+RTV AF+G+
Sbjct: 184 IVGLPFIVLLVIPGLMYGRALISISRKIREEYNEAGFVAEQAISSVRTVYAFSGERKTIS 243
Query: 755 RYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVF 934
++ AL+ K GIK+ G + S I +A + W G+ V + GTV V
Sbjct: 244 KFSTALQGSVKLGIKQGLAKGITIGSNG-ITFAMWGFMSWYGSRMVMYHGAQGGTVFAVA 302
Query: 935 FSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVN 1114
++ +G ++LG A + EVI+R+P+ID+ + +G KI G +
Sbjct: 303 AAIAIGGVSLGGGLSNLKYFFEAASVGERIMEVINRVPKIDSDNPDGHKLEKIRGEVEFK 362
Query: 1115 KVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDD 1294
V+F YP+R + I L G+TVALVG SG GKST+I LLQRFY+P AG+ILID
Sbjct: 363 NVKFVYPSRLETSIFDDFCLRVPSGKTVALVGGSGSGKSTVISLLQRFYDPLAGEILIDG 422
Query: 1295 IPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKT 1474
+ I+ +K+LR +G+VSQEP LF T+I++NI +G+ D S +D+ A K +NA +FI
Sbjct: 423 VSIDKLQVKWLRSQMGLVSQEPALFATTIKENILFGKEDASMDDVVEAAKASNAHNFISQ 482
Query: 1475 FPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALEN 1654
P G T VG+RGVQMSGGQKQRIAIARA++++P ILLLDEATSALD+ESE +VQ ALEN
Sbjct: 483 LPNGYETQVGERGVQMSGGQKQRIAIARAIIKSPTILLLDEATSALDSESERVVQEALEN 542
Query: 1655 ASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQ-KGLYHELVHAQ----- 1816
AS GRTTI+IAHRLST+RNAD I V+K G ++E G+H+ L+E G Y LVH Q
Sbjct: 543 ASIGRTTILIAHRLSTIRNADVISVVKNGHIVETGSHDELMENIDGQYSTLVHLQQIEKQ 602
Query: 1817 ------VFADVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXX 1978
+ D K R+S T R S N T S +
Sbjct: 603 DINVSVKIGPISDPSKDIRNSSRVS--TLSRSSSANSVTGPSTIKNLSEDNKPQL----- 655
Query: 1979 XXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVF 2158
+ ++L PEW + GA+ PA++ +++V+
Sbjct: 656 ---------------PSFKRLLAMNLPEWKQALYGCISATLFGAIQPAYAYSLGSMVSVY 700
Query: 2159 SNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQD 2338
D++K+ +AL F+ LA + + Q F E LT RIR ++ VL +
Sbjct: 701 FLTSHDEIKEKTRIYALSFVGLAVLSFLINISQHYNFAYMGEYLTKRIRERMLSKVLTFE 760
Query: 2339 ATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFL 2518
+FD ++S G I +RLA DA ++S + R+ + +++V + W++A +
Sbjct: 761 VGWFDRDENSSGAICSRLAKDANVVRSLVGDRMALVVQTVSAVTIAFTMGLVIAWRLALV 820
Query: 2519 VMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIF 2698
++A+ P + V + K + + K A EA+ N+RT+ A + Q ++ +
Sbjct: 821 MIAVQPVIIVCFYTRRVLLKSMSKKAIKAQDESSKLAAEAVSNVRTITAFSSQERIMKML 880
Query: 2699 CSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVL 2878
++P +I ++ G + S+ T+A F +G LI D + + L
Sbjct: 881 EKAQESPRRESIRQSWFAGFGLAMSQSLTSCTWALDFWYGGRLIQDGYITAK---ALFET 937
Query: 2879 FAISFSFG-TIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSG-TYPQLSGEVKL 3052
F I S G I A S + K + A G +F +L+ ID G +++G+V+
Sbjct: 938 FMILVSTGRVIADAGSMTTDLAKGSDAVGSVFAVLDRYTSIDPEDPDGYETERITGQVEF 997
Query: 3053 NKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVD 3232
V F YP RP V I + ++ ++ G++ A+VGPSG GKST+I L+ER YDPL+G V +D
Sbjct: 998 LDVDFSYPTRPDVIIFKNFSIKIEEGKSTAIVGPSGSGKSTIIGLIERFYDPLKGIVKID 1057
Query: 3233 NNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKF 3412
D+R + + LR+HIALVSQEP LF +IRENI+YG + +I A AN H F
Sbjct: 1058 GRDIRSYHLRSLRRHIALVSQEPTLFAGTIRENIIYGGVSDKIDEAEIIEAAKAANAHDF 1117
Query: 3413 IDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVA 3592
I L +GY+T G++G QLSGGQKQRIAIARA+++NP +LLLDEATSALD++SE+ VQ A
Sbjct: 1118 ITSLTEGYDTYCGDRGVQLSGGQKQRIAIARAVLKNPSVLLLDEATSALDSQSERVVQDA 1177
Query: 3593 LDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAK--RGAYFALTQKQS 3766
L+ RT +V+AHRLSTI N I V+ G++VE+GTH+ L++K G YF+L Q+
Sbjct: 1178 LERVMVGRTSVVIAHRLSTIQNCDAIAVLDKGKLVERGTHSSLLSKGPTGIYFSLVSLQT 1237
Query: 3767 SN 3772
++
Sbjct: 1238 TS 1239
>gi|15220188|ref|NP_172538.1| P-glycoprotein, putative [Arabidopsis
thaliana]
Length = 1227
Score = 723 bits (1865), Expect = 0.0
Identities = 435/1254 (34%), Positives = 678/1254 (53%), Gaps = 13/1254 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+S +L+ + D +++A+G I +C G +P+ I G + +G +L P
Sbjct: 24 VSFLKLFSFADFYDCVLMALGSIGACIHGASVPVFFIFFGKLIN---IIGLAYLFPQ--- 77
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
E SH+V + L +VYL I + +L+ +C+M E+ + + R+ + S++
Sbjct: 78 --------EASHKVAKYSLDFVYLSVVILFSSWLEVACWMHTGERQAAKIRKAYLRSMLS 129
Query: 401 QEIAWYDKNTS-GTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
Q+I+ +D S G + + + + V++ +KVG +++FI GFA+ F W ++L
Sbjct: 130 QDISLFDTEISTGEVISAITSEILVVQDAISEKVGNFMHFISRFIAGFAIGFASVWQISL 189
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
+ +S+ PF+ + G Y A IAEEV+ ++RTV AF G+E
Sbjct: 190 VTLSIVPFIALAGGIYAFVSSGLIVRVRKSYVKANEIAEEVIGNVRTVQAFTGEEKAVSS 249
Query: 758 YEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFF 937
Y+ AL + G K G GL S +++ S+ L W + V+ G G T
Sbjct: 250 YQGALRNTYNYGRKAGLAKGLGLGSLHFVLFLSWALLIWFTSIVVHKGIANGGESFTTML 309
Query: 938 SVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNK 1117
+V++ ++LGQA +T A AA ++++I+R E G+ ++G I
Sbjct: 310 NVVIAGLSLGQAAPDISTFMRASAAAYPIFQMIERNTE----DKTGRKLGNVNGDILFKD 365
Query: 1118 VEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDI 1297
V FTYP+R DV I ++ G+ VALVG SG GKST+I L++RFY P G +++D
Sbjct: 366 VTFTYPSRPDVVIFDKLNFVIPAGKVVALVGGSGSGKSTMISLIERFYEPTDGAVMLDGN 425
Query: 1298 PIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTF 1477
I ++K+LR +G+V+QEP LF T+I +NI YG+ D + E+I A K + A FI
Sbjct: 426 DIRYLDLKWLRGHIGLVNQEPVLFATTIRENIMYGKDDATSEEITNAAKLSEAISFINNL 485
Query: 1478 PEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENA 1657
PEG T VG+RG+Q+SGGQKQRI+I+RA+V+NP ILLLDEATSALDAESE IVQ AL+
Sbjct: 486 PEGFETQVGERGIQLSGGQKQRISISRAIVKNPSILLLDEATSALDAESEKIVQEALDRV 545
Query: 1658 SRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQ-KGLYHELVHAQVFA--D 1828
GRTT+V+AHRLSTVRNAD I V+ G+++E G+H+ LI G Y L+ Q A +
Sbjct: 546 MVGRTTVVVAHRLSTVRNADIIAVVGGGKIIESGSHDELISNPDGAYSSLLRIQEAASPN 605
Query: 1829 VDDKPK-----KKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXX 1993
++ P K E ++ TS SVN Q
Sbjct: 606 LNHTPSLPVSTKPLPELPITETTSSIHQSVNQPDTTKQ---------------------- 643
Query: 1994 XXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDR 2173
K + ++ RP+W Y I G+ MP F+L +Q + V D
Sbjct: 644 --------AKVTVGRLYSMIRPDWKYGLCGTLGSFIAGSQMPLFALGIAQAL-VSYYMDW 694
Query: 2174 DQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFD 2353
+ + + +++F + + + + FG+ ERLT+R+R K++ +LR + +FD
Sbjct: 695 ETTQNEVKRISILFCCGSVITVIVHTIEHTTFGIMGERLTLRVRQKMFSAILRNEIGWFD 754
Query: 2354 MPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIF 2533
++ + +RL +DA +++ + R + + V I+F W++ +V+A +
Sbjct: 755 KVDNTSSMLASRLESDATLLRTIVVDRSTILLENLGLVVTAFIISFILNWRLTLVVLATY 814
Query: 2534 PFMAVG---QALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCS 2704
P + G + + M+ +GG+ +K A A E+I NIRTV A + K+ +++
Sbjct: 815 PLIISGHISEKIFMQGYGGNL---SKAYLKANMLAGESISNIRTVVAFCAEEKVLDLYSK 871
Query: 2705 HLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFA 2884
L P + + + G+ YG + F +Y A +G L+ + L E+V++
Sbjct: 872 ELLEPSERSFRRGQMAGILYGVSQFFIFSSYGLALWYGSILM--EKGLSSFESVMKTFMV 929
Query: 2885 ISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVF 3064
+ + +G + P+ +K +F +L+ ++ G T + G ++L V
Sbjct: 930 LIVTALVMGEVLALAPDLLKGNQMVVSVFELLDRRTQVVGDTGE-ELSNVEGTIELKGVH 988
Query: 3065 FRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDL 3244
F YP RP V I N+ V G+++ALVG SG GKS+V+SL+ R YDP G + +D D+
Sbjct: 989 FSYPSRPDVTIFSDFNLLVPSGKSMALVGQSGSGKSSVLSLVLRFYDPTAGIIMIDGQDI 1048
Query: 3245 RQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDEL 3424
+++ K LR+HI LV QEP LF T+I ENI+YG + + ++ A AN H FI L
Sbjct: 1049 KKLKLKSLRRHIGLVQQEPALFATTIYENILYGKEGA--SESEVMEAAKLANAHSFISSL 1106
Query: 3425 PDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAA 3604
P+GY T+VGE+G Q+SGGQ+QRIAIARA+++NP+ILLLDEATSALD ESE+ VQ ALD
Sbjct: 1107 PEGYSTKVGERGIQMSGGQRQRIAIARAVLKNPEILLLDEATSALDVESERVVQQALDRL 1166
Query: 3605 AKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIA-KRGAYFALTQKQ 3763
+DRT +VVAHRLSTI N+ I V+++G+++EQG+HN L+ K G Y L Q
Sbjct: 1167 MRDRTTVVVAHRLSTIKNSDMISVIQDGKIIEQGSHNILVENKNGPYSKLISLQ 1220
Score = 333 bits (855), Expect = 1e-89
Identities = 210/564 (37%), Positives = 317/564 (55%), Gaps = 7/564 (1%)
Frame = +2
Query: 2099 IQGAVMPAFSLFFSQIINV------FSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQC 2260
I GA +P F +FF ++IN+ F ++ K ++L F+ L+ V S +
Sbjct: 50 IHGASVPVFFIFFGKLINIIGLAYLFPQEASHKVAK----YSLDFVYLSVVILFSSWLEV 105
Query: 2261 SLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLG 2440
+ + ER +IR R++L QD + FD + S G + + + ++ ++ AI ++G
Sbjct: 106 ACWMHTGERQAAKIRKAYLRSMLSQDISLFDT-EISTGEVISAITSEILVVQDAISEKVG 164
Query: 2441 SIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAG 2620
+ + I+ G I F WQ++ + ++I PF+A+ + G K A
Sbjct: 165 NFMHFISRFIAGFAIGFASVWQISLVTLSIVPFIALAGGIYAFVSSGLIVRVRKSYVKAN 224
Query: 2621 KTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYA 2800
+ A E I N+RTVQA T + K + + L + + +GL G + + F ++A
Sbjct: 225 EIAEEVIGNVRTVQAFTGEEKAVSSYQGALRNTYNYGRKAGLAKGLGLGSLHFVLFLSWA 284
Query: 2801 AAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNML 2980
F ++ K + E+ +L + ++G AA +++A+ AA IF M+
Sbjct: 285 LLIWF-TSIVVHKGIANGGESFTTMLNVVIAGL-SLGQAAPDISTFMRASAAAYPIFQMI 342
Query: 2981 EEEPRIDGMTSSGTYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSG 3160
E G ++G++ V F YP RP V I LN + G+ +ALVG SG
Sbjct: 343 ERNTEDKTGRKLGN---VNGDILFKDVTFTYPSRPDVVIFDKLNFVIPAGKVVALVGGSG 399
Query: 3161 CGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVY 3340
GKST+ISL+ER Y+P +GAV +D ND+R ++ K LR HI LV+QEP+LF T+IRENI+Y
Sbjct: 400 SGKSTMISLIERFYEPTDGAVMLDGNDIRYLDLKWLRGHIGLVNQEPVLFATTIRENIMY 459
Query: 3341 GLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRN 3520
G + T E+I A + FI+ LP+G+ET+VGE+G QLSGGQKQRI+I+RA+++N
Sbjct: 460 GKD--DATSEEITNAAKLSEAISFINNLPEGFETQVGERGIQLSGGQKQRISISRAIVKN 517
Query: 3521 PKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVE 3700
P ILLLDEATSALD ESEK VQ ALD RT +VVAHRLST+ NA I VV G+++E
Sbjct: 518 PSILLLDEATSALDAESEKIVQEALDRVMVGRTTVVVAHRLSTVRNADIIAVVGGGKIIE 577
Query: 3701 QGTHNELIAK-RGAYFALTQKQSS 3769
G+H+ELI+ GAY +L + Q +
Sbjct: 578 SGSHDELISNPDGAYSSLLRIQEA 601
>gi|27368861|emb|CAD59588.1| MDR-like ABC transporter [Oryza sativa
(japonica cultivar-group)]
Length = 1159
Score = 722 bits (1863), Expect = 0.0
Identities = 422/1190 (35%), Positives = 645/1190 (53%), Gaps = 24/1190 (2%)
Frame = +2
Query: 275 LKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYDKN-TSGTLSNK 451
+ ++YLG G LQ SC+ + E+ + R R + +++RQ+IA++DK +G L +
Sbjct: 1 MNFIYLGVGAGLVSALQVSCWTITGERQAARIRALYLKAILRQDIAFFDKEMNTGQLVER 60
Query: 452 LFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXXX 631
+ + +++ G+K G Q+++ F GGF +AF WLL L+M+S P + + G
Sbjct: 61 MSGDAFLIQDAIGEKAGKCIQLLSTFFGGFIIAFVRGWLLALVMLSSIPPVAVAGAIMSR 120
Query: 632 XXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFL 811
+Y AG + E+ + +IRTV+AFNG++ Y ++ ++ +++ +
Sbjct: 121 LMVKLTIRMQAKYGDAGIVVEQTIGAIRTVVAFNGEKKAINTYNKFIKKAYESALQQGVI 180
Query: 812 IGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQFAT 991
G GL S + ++SY LA W G+ + G V+ V ++M+ +M+LG A
Sbjct: 181 NGLGLGSIISVFFSSYGLAVWYGSRLIVERGYNGGIVINVIMAIMISAMSLGHATSSITA 240
Query: 992 IGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKGVS 1171
+ GAA L+ I+R P+IDA T G + G + + V F+YP+R + + G S
Sbjct: 241 LAGGQGAAYRLFRTIERQPDIDACCTTGDIFEDVKGDVELKNVYFSYPSRPEHLVFDGFS 300
Query: 1172 LDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVS 1351
L G +ALVG SG GKST+I L++RFY+P +G++LID + I N+ +R+ +G+VS
Sbjct: 301 LQVPSGTRMALVGESGSGKSTVISLVERFYDPQSGEVLIDGVDIRRINLGSIRRKIGLVS 360
Query: 1352 QEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQMSGG 1531
QEP LF +I +NI YG+ D + E+I RA++ ANAA FI P GL T+VG+RG+Q+SGG
Sbjct: 361 QEPVLFAGTIRENITYGKEDPTLEEINRAIELANAAKFIDKLPNGLETMVGERGIQLSGG 420
Query: 1532 QKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLSTVRN 1711
QKQRIAIAR +++NP+ILLLDEATSALD ESE +VQ AL RTTI++AHRLSTV+N
Sbjct: 421 QKQRIAIARVIIKNPRILLLDEATSALDMESERVVQEALNKVMLERTTIIVAHRLSTVKN 480
Query: 1712 ADKIIVMKAGQVMEVGTHETLIEQ-KGLYHELVHAQ-----VFADVDDKPK--KKEAERR 1867
AD I V++ G+++E G+HE L+++ +G Y +L+H Q A DD + + + R
Sbjct: 481 ADMISVLQHGKLVEQGSHEELMKKPEGSYCKLIHLQETRQEAVAPNDDPDMIIRNDFDSR 540
Query: 1868 MSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXX-----------XXXXXXXXXXXXXG 2014
+ + R +++F+ S+
Sbjct: 541 II-NSKTRSQNISFRKSTSKSSSFGHSGTHPFTSTCDLSDPMEVHDDQHIKETTDKMSNC 599
Query: 2015 AVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDG 2194
KA++ ++ +PE + G + P F + S I +F P R ++ K+
Sbjct: 600 QEKASILRLFSLNKPEAFVLALGSITAAMHGVIFPVFGILVSSAIKMFYEP-RSELLKNS 658
Query: 2195 HFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPG 2374
MF VL + + LFG+A +L RIRS +++V+ Q+ ++FD P++S G
Sbjct: 659 RLLGSMFPVLGISTFLLIPTEYFLFGLAGGKLVERIRSLTFKSVMYQEISWFDKPENSSG 718
Query: 2375 RITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFP---FMA 2545
I RL+TDA N+K + L F ++++ G IA W++A ++ + P F A
Sbjct: 719 SIGARLSTDALNVKRLVGDNLALNFQTLSTIISGFTIAMVANWKLALIITVVVPLVGFQA 778
Query: 2546 VGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHG 2725
Q + +K +A S E+A + A EA+ IRT+ + + K+ N + +P
Sbjct: 779 YAQMMFLKGFNKNAKS---MFEDATQVATEAVGGIRTITSFCAEQKVMNAYEKKCASPII 835
Query: 2726 GNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGT 2905
I ++ L +GF+ + +F YA F G + V RV F +
Sbjct: 836 QGIRDGVVGALGFGFSFLVFYFAYALCFYVGAKFVHQGTATF--AEVFRVFFVLVLGINE 893
Query: 2906 IGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVFFRYPERP 3085
I ++ E + + +F +L+ + +ID G
Sbjct: 894 ISRTSAIGSESRRVNESVVSVFKILDRKSKIDSSNDEGV--------------------- 932
Query: 3086 AVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKH 3265
++ + ++ T ALVG SG GKSTVISLLER Y+P G + D +L +
Sbjct: 933 ---VIASVRGDIEFQNTAALVGESGSGKSTVISLLERFYEPDAGRILFDGVELETLKVSW 989
Query: 3266 LRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETR 3445
LR I LV+QEP+LF+ +IR NI YG Q G+ + E+I A AN H+FI LPDGY T
Sbjct: 990 LRLQIGLVAQEPVLFNDTIRANIAYGKQ-GDASEEEIIAAAEAANAHQFISGLPDGYNTI 1048
Query: 3446 VGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCI 3625
VGE+G QLSGGQKQR+AIARA+I++PK+LLLDEATSALD+ESE+ VQ ALD RT +
Sbjct: 1049 VGERGIQLSGGQKQRVAIARAVIKDPKVLLLDEATSALDSESERVVQEALDREVVGRTTV 1108
Query: 3626 VVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELI-AKRGAYFALTQKQSSN 3772
VVAHRLSTI A I V++NG +VE+G H EL+ K G Y +L + SS+
Sbjct: 1109 VVAHRLSTIKGADIIGVLENGTIVEKGRHEELMQIKGGIYSSLVELSSSS 1158
Score = 350 bits (897), Expect = 2e-94
Identities = 212/527 (40%), Positives = 303/527 (57%), Gaps = 2/527 (0%)
Frame = +2
Query: 2213 FLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRL 2392
F+ L G Q S + + ER RIR+ + +LRQD +FD ++ G++ R+
Sbjct: 3 FIYLGVGAGLVSALQVSCWTITGERQAARIRALYLKAILRQDIAFFDKEMNT-GQLVERM 61
Query: 2393 ATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKY 2572
+ DA I+ AI + G +++ GG IAF GW +A ++++ P +AV A+M +
Sbjct: 62 SGDAFLIQDAIGEKAGKCIQLLSTFFGGFIIAFVRGWLLALVMLSSIPPVAVAGAIMSRL 121
Query: 2573 HGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIR 2752
+ +AG + I IRTV A + K N + + + + + +I
Sbjct: 122 MVKLTIRMQAKYGDAGIVVEQTIGAIRTVVAFNGEKKAINTYNKFIKKAYESALQQGVIN 181
Query: 2753 GLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFP 2932
GL G S+ F +Y A +G LI ++ V+ V+ AI S ++G A S
Sbjct: 182 GLGLGSIISVFFSSYGLAVWYGSRLIVERGY--NGGIVINVIMAIMISAMSLGHATSSIT 239
Query: 2933 EYIKATFAAGLIFNMLEEEPRIDGMTSSGT-YPQLSGEVKLNKVFFRYPERPAVPILQGL 3109
AA +F +E +P ID ++G + + G+V+L V+F YP RP + G
Sbjct: 240 ALAGGQGAAYRLFRTIERQPDIDACCTTGDIFEDVKGDVELKNVYFSYPSRPEHLVFDGF 299
Query: 3110 NVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALV 3289
++ V G +ALVG SG GKSTVISL+ER YDP G V +D D+R++N +R+ I LV
Sbjct: 300 SLQVPSGTRMALVGESGSGKSTVISLVERFYDPQSGEVLIDGVDIRRINLGSIRRKIGLV 359
Query: 3290 SQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQL 3469
SQEP+LF +IRENI YG + + T E+I A AN KFID+LP+G ET VGE+G QL
Sbjct: 360 SQEPVLFAGTIRENITYGKE--DPTLEEINRAIELANAAKFIDKLPNGLETMVGERGIQL 417
Query: 3470 SGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLST 3649
SGGQKQRIAIAR +I+NP+ILLLDEATSALD ESE+ VQ AL+ +RT I+VAHRLST
Sbjct: 418 SGGQKQRIAIARVIIKNPRILLLDEATSALDMESERVVQEALNKVMLERTTIIVAHRLST 477
Query: 3650 IVNAGCIMVVKNGQVVEQGTHNELIAK-RGAYFALTQKQSSNQSGGA 3787
+ NA I V+++G++VEQG+H EL+ K G+Y L Q + Q A
Sbjct: 478 VKNADMISVLQHGKLVEQGSHEELMKKPEGSYCKLIHLQETRQEAVA 524
Score = 329 bits (844), Expect = 3e-88
Identities = 204/592 (34%), Positives = 309/592 (51%), Gaps = 4/592 (0%)
Frame = +2
Query: 44 SIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTAS 223
SI +L+ + +LA+G I + GV P+ I++ + + +F +P S
Sbjct: 604 SILRLFSLNKP-EAFVLALGSITAAMHGVIFPVFGILVSSAIK-------MFYEPRSELL 655
Query: 224 EKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQ 403
+ + + LG F + F + KL R R F SVM Q
Sbjct: 656 KNSRLLGSM----------FPVLGISTFLLIPTEYFLFGLAGGKLVERIRSLTFKSVMYQ 705
Query: 404 EIAWYDK--NTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
EI+W+DK N+SG++ +L + V+ GD + L FQ ++ I GF +A +W L L
Sbjct: 706 EISWFDKPENSSGSIGARLSTDALNVKRLVGDNLALNFQTLSTIISGFTIAMVANWKLAL 765
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
I+ + P + + A +A E + IRT+ +F ++
Sbjct: 766 IITVVVPLVGFQAYAQMMFLKGFNKNAKSMFEDATQVATEAVGGIRTITSFCAEQKVMNA 825
Query: 758 YEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFF 937
YE GI+ + G F++ Y +Y L F+VG FV+ G V VFF
Sbjct: 826 YEKKCASPIIQGIRDGVVGALGFGFSFLVFYFAYALCFYVGAKFVHQGTATFAEVFRVFF 885
Query: 938 SVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNK 1117
+++G + + + + S+++++DR +ID+ + EG + + G I
Sbjct: 886 VLVLGINEISRTSAIGSESRRVNESVVSVFKILDRKSKIDSSNDEGVVIASVRGDIEFQN 945
Query: 1118 VEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDI 1297
T ALVG SG GKST+I LL+RFY PDAG+IL D +
Sbjct: 946 -------------------------TAALVGESGSGKSTVISLLERFYEPDAGRILFDGV 980
Query: 1298 PIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRS-DVSDEDIARALKEANAADFIKT 1474
+E + +LR +G+V+QEP LFN +I NI YG+ D S+E+I A + ANA FI
Sbjct: 981 ELETLKVSWLRLQIGLVAQEPVLFNDTIRANIAYGKQGDASEEEIIAAAEAANAHQFISG 1040
Query: 1475 FPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALEN 1654
P+G NT+VG+RG+Q+SGGQKQR+AIARA++++PK+LLLDEATSALD+ESE +VQ AL+
Sbjct: 1041 LPDGYNTIVGERGIQLSGGQKQRVAIARAVIKDPKVLLLDEATSALDSESERVVQEALDR 1100
Query: 1655 ASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQK-GLYHELV 1807
GRTT+V+AHRLST++ AD I V++ G ++E G HE L++ K G+Y LV
Sbjct: 1101 EVVGRTTVVVAHRLSTIKGADIIGVLENGTIVEKGRHEELMQIKGGIYSSLV 1152
>gi|7494503|pir||T30855 multidrug resistance protein 2 - fluke
(Schistosoma mansoni)
gi|425476|gb|AAA66477.1| SMDR2
Length = 1254
Score = 719 bits (1855), Expect = 0.0
Identities = 439/1249 (35%), Positives = 661/1249 (52%), Gaps = 12/1249 (0%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+S +L++Y ST + ++ +G I + G+ P ++ ++ +
Sbjct: 29 VSFGKLFQYASTCHKFLIIIGNICAILLGISFPASILVFRSMINGLFNRSS--------- 79
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
S+ + Y + IF + C +++ + + ++ +V+
Sbjct: 80 ----------SNNIYGLLGWYFLMAILIFVLCMWKCVCVEFASKRIVQQIQLLYYQAVLH 129
Query: 401 QEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLI 580
+++ W+D + +G + N L +NL + G G K+ Q M+ F+ G + F W L L+
Sbjct: 130 KDVLWFDDHPTGDIINNLTENLNSIESGIGTKLSDFNQNMSGFLAGIIIGFIVKWKLALV 189
Query: 581 MMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRY 760
S PF++I Y+ A I+ EVL+SIRTVIAF G++ E RY
Sbjct: 190 ACSTLPFVVIAFSLFGIAFKYFHGKEIKAYSRACTISNEVLSSIRTVIAFGGEKRESLRY 249
Query: 761 EDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFS 940
+ L + GIKK+ G+ ++I++S L FW G + + G+V+TVF +
Sbjct: 250 QKELTSAELMGIKKATAFGSVGGCIGLVIFSSAALVFWFGVKLIRDEDADPGSVITVFIN 309
Query: 941 VMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKV 1120
+++GS+ LG A I A+ A+ ++ ID + EI+ G+ S G I+ V
Sbjct: 310 ILLGSIFLGNALPNIPYIMGAVTASKDIFATIDHVCEIEK-KDRGKILSDFDGSITFRHV 368
Query: 1121 EFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIP 1300
F YP+R DV IL L + GQT+ALVGSSG GKST+I +LQRFY+P G+ILI +
Sbjct: 369 NFNYPSRPDVTILVNFCLTVKSGQTIALVGSSGSGKSTLIHMLQRFYDPTQGEILIQGVD 428
Query: 1301 IEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFP 1480
+ + NI R +G V QEP LF+ +I +NI G+ + +DE+I A +ANA FI P
Sbjct: 429 LRELNIHNYRNQIGCVQQEPVLFDGTIRENIGLGKLNATDEEIHEAAIKANAHQFIMRLP 488
Query: 1481 EGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENAS 1660
+G +TLVG++G +SGGQKQRIAIAR L+R PK+LLLDEATSALD +SE IVQ AL+
Sbjct: 489 QGYDTLVGEKGSNLSGGQKQRIAIARVLIRKPKLLLLDEATSALDTQSERIVQGALDKIV 548
Query: 1661 RGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVDDK 1840
G T I+IAHRLST+ NAD IIV+ G + E+G H L++ GLY + + Q D + +
Sbjct: 549 GGCTVIIIAHRLSTIINADYIIVLDQGCIREMGKHNELLKLNGLYATMYYGQEGIDKEQE 608
Query: 1841 PKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXGAV 2020
+ S+R + + + + D V
Sbjct: 609 DSTDDEVDHNQNDGSKRHLTNHHPSPFPKDDYSECSNVTTSSLHNKTVIWLTTNINTKLV 668
Query: 2021 KANL--FKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFS-NPDRDQMKKD 2191
+ + F L RPE IY +I G + PAFSL +S++ VF D+M K
Sbjct: 669 ELTILVFASLSINRPEMIYIIMGCFCSIISGLLQPAFSLLYSEVYQVFDLRKTPDEMTKK 728
Query: 2192 GHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSP 2371
+ + + L +Q Q LFGVAAERLT R+RS ++ ++L+Q+ +FD + P
Sbjct: 729 INMVSGIMAGLGFIQLFIGATQGYLFGVAAERLTKRLRSNLFDSMLKQEIGWFDRSDNRP 788
Query: 2372 GRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVG 2551
G +T L+TDA + RL + F A+ V L I F Y WQ+ +++ P + +
Sbjct: 789 GALTAFLSTDASKVAQISGSRLSTAFEAVVLVIASLVIGFIYSWQLTLVMIPFIPVLLLS 848
Query: 2552 QALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIF---CSHLDAPH 2722
+ MK + ++ K + A E+I RTV++L+L+ Y F C + H
Sbjct: 849 SRINMK---RVSKNEDKIVAKGISIAKESISAHRTVKSLSLEEYFYQRFKLACIECSSTH 905
Query: 2723 GGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFG 2902
+ +AI GL A S + A F G +LI + M ++ +V S
Sbjct: 906 ---LQEAIKIGLVQSIALSGPVLSLTACFALGNYLIQQNAISM--ISLFKVFITFSMCSQ 960
Query: 2903 TIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYP--QLSGEVKLNKVFFRYP 3076
+G ++ + +A A G IF +++ +P I+ T+ G P + +G ++ V FRYP
Sbjct: 961 ALGRITAFTTKTKEAEEAMGRIFTVIDRKPSIE--TNQGDQPKEKFNGLIEFKHVNFRYP 1018
Query: 3077 ERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDP----LEGAVTVDNNDL 3244
RP +L ++PG +ALVG SGCGKST+I LL+R YDP L + D +L
Sbjct: 1019 TRPETKVLNNFTYRIQPGSKIALVGQSGCGKSTLIQLLQRFYDPTDHGLHNGIFFDGINL 1078
Query: 3245 RQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDEL 3424
RQ+ P +R+ I +VSQEPILF+ S+R+NI YG + ++I A ANIH FI L
Sbjct: 1079 RQLAPYWIRRQIGIVSQEPILFNISLRDNIAYGDNSRIVSMDEIIEAAKLANIHDFILSL 1138
Query: 3425 PDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAA 3604
P+ YET G+ G+ LSGGQKQRIAIARA+IR P +LLLDEATSALD E+++ VQ ALD A
Sbjct: 1139 PNAYETLAGQDGSHLSGGQKQRIAIARAIIRKPTLLLLDEATSALDNENQRLVQKALDDA 1198
Query: 3605 AKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFAL 3751
RT I++AHRL+TI I+V+ NG+++E G NELI ++G +F L
Sbjct: 1199 MVTRTSIIIAHRLNTIEKVDYIIVLSNGRIIEYGKLNELIHRKGEFFNL 1247
>gi|22331385|ref|NP_683599.1| P-glycoprotein, putative [Arabidopsis
thaliana]
Length = 1221
Score = 718 bits (1854), Expect = 0.0
Identities = 436/1251 (34%), Positives = 677/1251 (53%), Gaps = 11/1251 (0%)
Frame = +2
Query: 44 SIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTAS 223
S+ ++ + ++VD +++ +G+I + G P++ I G + + +S+
Sbjct: 6 SVRSIFMHANSVDLVLMGLGLIGAVGDGFITPIIFFITGLLLNDI---------GDSSFG 56
Query: 224 EKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQ 403
+K F H +++N + +Y+ AG CF + E+ ++R R ++ +V+RQ
Sbjct: 57 DKT-----FMHAIMKNAVALLYV------AGASLVICF--VGERQASRMREKYLRAVLRQ 103
Query: 404 EIAWYD---KNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLT 574
++ ++D +TS +++ D L +++ +K+ + F+ + V F W LT
Sbjct: 104 DVGYFDLHVTSTSDVITSVSSDTLV-IQDVLSEKLPNFLMSASAFVASYIVGFIMLWRLT 162
Query: 575 LIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECK 754
++ ++I GL +Y AG IAE+ ++ +RTV AF +
Sbjct: 163 IVGFPFFILLLIPGLMCGRALINISRKIREEYNEAGSIAEQAISLVRTVYAFGSERKMIS 222
Query: 755 RYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVF 934
++ ALE K G+++ G + S V YA + W G+ V + GT+ V
Sbjct: 223 KFSAALEGSVKLGLRQGIAKGIAIGSNGVT-YAIWGFMTWYGSRMVMYHGAKGGTIFAVI 281
Query: 935 FSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVN 1114
+ G +LG+ A+ A + EVI R+P+ID+ + GQ I G +
Sbjct: 282 ICITYGGTSLGRGLSNLKYFSEAVVAGERIIEVIKRVPDIDSDNPRGQVLENIKGEVQFK 341
Query: 1115 KVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDD 1294
V+F Y +R + I + L G++VALVG SG GKST+I LLQRFY+P G+ILID
Sbjct: 342 HVKFMYSSRPETPIFDDLCLRIPSGKSVALVGGSGSGKSTVISLLQRFYDPIVGEILIDG 401
Query: 1295 IPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKT 1474
+ I+ +K+LR +G+VSQEP LF TSIE+NI +G+ D S +++ A K +NA DFI
Sbjct: 402 VSIKKLQVKWLRSQMGLVSQEPALFATSIEENILFGKEDASFDEVVEAAKSSNAHDFISQ 461
Query: 1475 FPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALEN 1654
FP G T VG+RGVQMSGGQKQRI+IARA++++P +LLLDEATSALD+ESE +VQ AL+N
Sbjct: 462 FPLGYKTQVGERGVQMSGGQKQRISIARAIIKSPTLLLLDEATSALDSESERVVQEALDN 521
Query: 1655 ASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQ-KGLYHELVHAQVFADV 1831
A+ GRTTIVIAHRLST+RN D I V K GQ++E G+HE L+E G Y LV Q+
Sbjct: 522 ATIGRTTIVIAHRLSTIRNVDVICVFKNGQIVETGSHEELMENVDGQYTSLVRLQIM--- 578
Query: 1832 DDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXX 2011
+ +E+ +S S R+G + ++ +
Sbjct: 579 ----ENEESNDNVS--VSMREGQFSNFNKDVKYSSRLSIQSRSSLFATSSIDTNLAGSIP 632
Query: 2012 GAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKD 2191
K + +++ +PEW + ++ GA+ P ++ +++V+ D+MK+
Sbjct: 633 KDKKPSFKRLMAMNKPEWKHALYGCLSAVLYGALHPIYAYASGSMVSVYFLTSHDEMKEK 692
Query: 2192 GHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSP 2371
+ L+F+ LA + + Q F E LT RIR + +L + ++FD ++S
Sbjct: 693 TRIYVLLFVGLAVLCFLISIIQQYSFAYMGEYLTKRIRENILSKLLTFEVSWFDEDENSS 752
Query: 2372 GRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVG 2551
G I +RLA DA ++S + R+ + I++V + W+++ +++AI P + VG
Sbjct: 753 GSICSRLAKDANVVRSLVGERVSLLVQTISAVSVACTLGLAISWKLSIVMIAIQP-VVVG 811
Query: 2552 ----QALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAP 2719
Q +++K A K + + K A EA+ NIRT+ A + Q ++ + + P
Sbjct: 812 CFYTQRIVLKSISKKA---IKAQDESSKLAAEAVSNIRTITAFSSQERILKLLKMVQEGP 868
Query: 2720 HGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSF 2899
NI ++ + G+ + S+ T A + +G LI D + + L +LF +
Sbjct: 869 QRENIRQSWLAGIVLATSRSLMTCTSALNYWYGARLIIDGKITSKAFFELFILFVSTGR- 927
Query: 2900 GTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKLNKVFFRYP 3076
I A + + K + A G +F +L+ I+ G PQ + G++K V F YP
Sbjct: 928 -VIADAGAMTMDLAKGSDAVGSVFAVLDRYTNIEPEKPDGFVPQNIKGQIKFVNVDFAYP 986
Query: 3077 ERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMN 3256
RP V I + ++ + G++ A+VGPSG GKST+I L+ER YDPL+G V +D D+R +
Sbjct: 987 TRPDVIIFKNFSIDIDEGKSTAIVGPSGSGKSTIIGLIERFYDPLKGIVKIDGRDIRSYH 1046
Query: 3257 PKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGY 3436
+ LR+HI LVSQEPILF +IRENI+YG + +I A AN H FI L DGY
Sbjct: 1047 LRSLRQHIGLVSQEPILFAGTIRENIMYGGASDKIDESEIIEAAKAANAHDFIVTLSDGY 1106
Query: 3437 ETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDR 3616
+T G++G QLSGGQKQRIAIARA+++NP +LLLDEATSALD +SE+ VQ AL R
Sbjct: 1107 DTYCGDRGVQLSGGQKQRIAIARAVLKNPSVLLLDEATSALDNQSERMVQDALGRLMVGR 1166
Query: 3617 TCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAK--RGAYFALTQKQ 3763
T +V+AHRLSTI N I V+ G+VVE GTH+ L+AK G YF+L Q
Sbjct: 1167 TSVVIAHRLSTIQNCDTITVLDKGKVVECGTHSSLLAKGPTGVYFSLVSLQ 1217
>gi|5733124|gb|AAD49436.1| P-glycoprotein [Onchocerca volvulus]
Length = 1278
Score = 718 bits (1853), Expect = 0.0
Identities = 449/1254 (35%), Positives = 673/1254 (52%), Gaps = 13/1254 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+S FQL+R+ +T DR ML++ +++ TG+G P++ +I G ++ F+ T + N T
Sbjct: 46 VSFFQLFRFATTCDRFMLSISALLAIFTGIGQPMICLIGGKLTNVFLLTKTF--ERNDT- 102
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
F ++ Y +G + +Q C ++ R+++ S++R
Sbjct: 103 ---------FWYQAYIYVYLYASIGITMVITTTIQYICAKNASLNITCTMRQEYMKSLLR 153
Query: 401 QEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLI 580
QE AW+D+ +GTL+ +L N+E++++G GDKVG+ + + F+ + F YDW LTL+
Sbjct: 154 QEAAWFDQQKTGTLTAQLNANIEKIKDGIGDKVGMILRGVTMFLTCVIIGFIYDWRLTLV 213
Query: 581 MMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRY 760
M P A + EE + +++TV A N QE KRY
Sbjct: 214 MFGTGPISAALLSTMARQMEHSSSMQSNTDGRAAAVLEESIMNVKTVAACNAQETMIKRY 273
Query: 761 EDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRL--ESGTVLTVF 934
L+ +K + G FF+++Y + F+ G ++Y R+ G + V
Sbjct: 274 AATLKACRKFALHAYAFAGFFDGLFFLVLYVFFAAGFYYGA-YLYQIRIIMNPGYIFAVA 332
Query: 935 FSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVN 1114
+M GS LG + A AAA +Y++I+R P D+ ST+G +++ G I
Sbjct: 333 NLIMFGSYNLGVLSPHLMAVLNARVAAAVIYKIINRKPSFDSSSTDGMKVNEVKGEIEFQ 392
Query: 1115 KVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDD 1294
V+F+YP + +L G+S A+PG TVALVG SGCGKST LL R YN ++G ILID
Sbjct: 393 NVKFSYPKSKEHLVLNGLSWTAKPGDTVALVGHSGCGKSTSTGLLTRLYNCNSGAILIDG 452
Query: 1295 IPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKT 1474
I I D NI LR +VGVV QEP LF+ +I++NIR G+ D++D++I A K ANA DFI
Sbjct: 453 INICDINIHTLRNIVGVVQQEPLLFSGTIKENIRLGKLDLTDQEIIDACKIANAHDFINK 512
Query: 1475 FPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALEN 1654
EG +T++G G+Q+SGGQKQRIAIAR +VRNP+ILLLDEATSALDAESE IVQ+AL+
Sbjct: 513 LSEGYDTMIGAGGIQLSGGQKQRIAIARTIVRNPRILLLDEATSALDAESEVIVQNALKK 572
Query: 1655 ASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQK-GLYHELVHAQVFADV 1831
A GRTTI+IAHRLST+R++++IIV+ GQV E+GTH+ L K G+Y LV +Q F +
Sbjct: 573 AFVGRTTIIIAHRLSTLRDSNQIIVLDKGQVAEIGTHKELCNNKDGIYASLVKSQQF-EA 631
Query: 1832 DDKPKKKEAE-------RRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXX 1990
KP E R + + S+ + ++
Sbjct: 632 QQKPTSPPVEELPLETFHRSNTRDSRNSSGYGIMSSFTRGSIMSGNVTCVSIPEKSTEIT 691
Query: 1991 XXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPD 2170
+ L+++ + ++G +P F L F VF+
Sbjct: 692 VELNGKKKSKPKGLWQLYTNCHGNYGKMIIALLVSFLRGLELPLFVLIFDLTFVVFAQAK 751
Query: 2171 RDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYF 2350
+ + + A++++ L + FG AE + +R + RN+L Q+A YF
Sbjct: 752 LESVLERILPIAIIYIALGIACLIVIFSATFTFGWTAECVVDSLRLRAMRNMLYQNAEYF 811
Query: 2351 DMPKHSPGRITTRLATDAPNIK---SAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLV 2521
D P S TR++ DA +K SA D +I + V IA + W + L
Sbjct: 812 DTPSTSTAVTVTRISVDAQTLKRSRSANDANFDNIVAILVLV----TIAVIFNWPVGLLA 867
Query: 2522 MAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFC 2701
+ P + KY+ K++ G+ A+E +E IRT+Q +T + + ++
Sbjct: 868 VK-SPVTHFDADIDRKYNAEVNKCALKQIV-TGQLALEIVEQIRTIQLITGEEHFHRLYV 925
Query: 2702 SHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLF 2881
++ + + + +S FF+ ++ G+ LI+ L P+ + +
Sbjct: 926 QTIEDLLYLQKKSSPYEAILFAVTSSFMFFSDMISYAAGIALIYYGYSL--PQEIFTASW 983
Query: 2882 AISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKV 3061
+I+ S + + ++ A+ A+ +F ++ ++ + G P ++G+V+ NK+
Sbjct: 984 SIATSGWALIMVSGCLNTFVMASPASNSLFRIINTGSDMNSV-DDGLRPAITGDVQFNKI 1042
Query: 3062 FFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNND 3241
F YP RP +L GLN+ GQT+A+ GPSG GKSTVI+LLER Y G +T+D+N
Sbjct: 1043 KFSYPTRPQRNVLNGLNLAAYAGQTVAVTGPSGSGKSTVIALLERFYRFNSGQLTLDDNS 1102
Query: 3242 LRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDE 3421
+ +++ ++LR+ IALV QEPILF +I ENI+ G T + AC ANI FI+
Sbjct: 1103 ITKISLRYLREQIALVGQEPILFSGTILENILLGTT--GKTLSDVREACKIANIIDFIET 1160
Query: 3422 LPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDA 3601
P GY+T VGE G QLSGGQKQRIAIARAL+RNPKILLLDEATSALD E E+ VQ ALDA
Sbjct: 1161 SPKGYDTEVGEHGVQLSGGQKQRIAIARALVRNPKILLLDEATSALDAECERTVQQALDA 1220
Query: 3602 AAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQ 3763
A+ RTCI VAHRLS+I +A I V+NG+VVE+GTH EL+ G Y L +KQ
Sbjct: 1221 ASSGRTCITVAHRLSSIQHADQIFFVENGKVVEEGTHQELVEFDGKYADLIRKQ 1274
Score = 300 bits (768), Expect = 2e-79
Identities = 194/590 (32%), Positives = 303/590 (50%), Gaps = 7/590 (1%)
Frame = +2
Query: 2015 AVKANLFKILRYARP-EWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKD 2191
A + F++ R+A + + G P L ++ NVF +
Sbjct: 43 AKPVSFFQLFRFATTCDRFMLSISALLAIFTGIGQPMICLIGGKLTNVFLLTKTFERNDT 102
Query: 2192 GHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRI----RSKVYRNVLRQDATYFDMP 2359
+ A +++ L A G +M+ ++ + A+ ++ I R + +++LRQ+A +FD
Sbjct: 103 FWYQAYIYVYLYASIGITMVITTTIQYICAKNASLNITCTMRQEYMKSLLRQEAAWFDQQ 162
Query: 2360 KHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPF 2539
K G +T +L + IK I ++G I + + I F Y W++ ++ P
Sbjct: 163 K--TGTLTAQLNANIEKIKDGIGDKVGMILRGVTMFLTCVIIGFIYDWRLTLVMFGTGPI 220
Query: 2540 MAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAP 2719
A + M + S++ + A E+I N++TV A Q + + + L A
Sbjct: 221 SAALLSTMARQMEHSSSMQSNTDGRAAAVLEESIMNVKTVAACNAQETMIKRYAATLKAC 280
Query: 2720 HGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSF 2899
+ G G + + +AA F +G +L + ++M P + V I F
Sbjct: 281 RKFALHAYAFAGFFDGLFFLVLYVFFAAGFYYGAYL-YQIRIIMNPGYIFAVANLIMFGS 339
Query: 2900 GTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGT-YPQLSGEVKLNKVFFRYP 3076
+G + + + A AA +I+ ++ +P D ++ G ++ GE++ V F YP
Sbjct: 340 YNLGVLSPHLMAVLNARVAAAVIYKIINRKPSFDSSSTDGMKVNEVKGEIEFQNVKFSYP 399
Query: 3077 ERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMN 3256
+ +L GL+ KPG T+ALVG SGCGKST LL RLY+ GA+ +D ++ +N
Sbjct: 400 KSKEHLVLNGLSWTAKPGDTVALVGHSGCGKSTSTGLLTRLYNCNSGAILIDGINICDIN 459
Query: 3257 PKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGY 3436
LR + +V QEP+LF +I+ENI G + T ++I AC AN H FI++L +GY
Sbjct: 460 IHTLRNIVGVVQQEPLLFSGTIKENIRLGKL--DLTDQEIIDACKIANAHDFINKLSEGY 517
Query: 3437 ETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDR 3616
+T +G G QLSGGQKQRIAIAR ++RNP+ILLLDEATSALD ESE VQ AL A R
Sbjct: 518 DTMIGAGGIQLSGGQKQRIAIARTIVRNPRILLLDEATSALDAESEVIVQNALKKAFVGR 577
Query: 3617 TCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELI-AKRGAYFALTQKQ 3763
T I++AHRLST+ ++ I+V+ GQV E GTH EL K G Y +L + Q
Sbjct: 578 TTIIIAHRLSTLRDSNQIIVLDKGQVAEIGTHKELCNNKDGIYASLVKSQ 627
>gi|7508147|pir||T25083 hypothetical protein T21E8.1 - Caenorhabditis
elegans
Length = 1114
Score = 715 bits (1846), Expect = 0.0
Identities = 415/1125 (36%), Positives = 617/1125 (53%), Gaps = 1/1125 (0%)
Frame = +2
Query: 56 LYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAA 235
+++ +S ++ + +G++ S TG P MS G VSQ VT+ + ++
Sbjct: 31 VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEK 90
Query: 236 ARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAW 415
A E+ + Q + GC F LQ + + + + R R+Q+ +++++ +
Sbjct: 91 AYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQY 150
Query: 416 YDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLS 595
+D ++G LS L DNLER RE +K+ L + F G A+AF DW L + S
Sbjct: 151 FDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFS 210
Query: 596 PFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALE 775
+ G YA AG IA + L + +TV + NGQ+ E +RY + L+
Sbjct: 211 LGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELK 270
Query: 776 HGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGS 955
G+K GI+++ + + + + +VG +YSG LE+ V+
Sbjct: 271 AGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYSGTLETAVVVRD-------- 322
Query: 956 MALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYP 1135
D + E D T+ +++G IS V+F+YP
Sbjct: 323 ---------------------------DNVIEKD--ETDYDVEVEVNGNISFKNVKFSYP 353
Query: 1136 TRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFN 1315
TR D ++LKG+S D Q G+ +ALVG+SG GKST++QLL +YN D+G I ID + + D N
Sbjct: 354 TRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMN 413
Query: 1316 IKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEGLNT 1495
IK LR+++GVVSQEP LFNT+IE+NIR+G +VS +I AL++ANA DF+ +FP+G+ T
Sbjct: 414 IKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKT 473
Query: 1496 LVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTT 1675
+VG+RG Q+SGGQKQRIAIAR LVRNPKILLLDEATSALD ESE +VQ ALENAS+GRTT
Sbjct: 474 IVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTT 533
Query: 1676 IVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVDDKPKKKE 1855
IV+AHRLST+RNA KIIVM+ G+++EVG H+ LI ++G+Y++LV AQ+ DD +E
Sbjct: 534 IVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLESHDD---HEE 590
Query: 1856 AERRMSRQTSQRKGSV-NFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXGAVKANL 2032
+RQ SQ + ++ Q S GA K+NL
Sbjct: 591 LPPLAARQLSQELSPLHSYAIQRS-------TSNDAGVHDDDMERILDELSKEGAKKSNL 643
Query: 2033 FKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHFWALM 2212
+I++ RP++ + IQG P + + F+ D M H WAL
Sbjct: 644 REIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGED-MLYYSHLWALS 702
Query: 2213 FLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRL 2392
F+ LA + ++ Q FG +E+L+ R+R K + ++L ++D P HS R++ RL
Sbjct: 703 FMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRL 762
Query: 2393 ATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKY 2572
TD+ N+K+A+D RLG + + ++ + A Y W+M V+ FP + + +
Sbjct: 763 NTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPLLYLAEYCYEAA 822
Query: 2573 HGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIR 2752
+ D EN+ +TA+EA+EN+RTV+AL L+ K+ ++ HL H +AII+
Sbjct: 823 TETAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQ 882
Query: 2753 GLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFP 2932
G G + S F Y+ +F+FG +L K V P + VL +S + G AA+Y P
Sbjct: 883 GAANGLSLSCFLFVYSVSFKFGTYLALRKEV--APMDTYLVLMTLSMTANMAGSAAAYLP 940
Query: 2933 EYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVFFRYPERPAVPILQGLN 3112
+Y KA AAGLIF++ + +S G GE+ V F Y +RP IL G+N
Sbjct: 941 DYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVN 1000
Query: 3113 VHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVS 3292
+ V PG+TLALVGPSGCGKST+ISLLER Y ++G V +D+ ++ +N HLR ++ALVS
Sbjct: 1001 LKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVS 1060
Query: 3293 QEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELP 3427
QEP LF+ SIREN++YGL ++E A AN F+ + P
Sbjct: 1061 QEPTLFNCSIRENLLYGL-TRSVPQLELEKALQTANAFNFVFQFP 1104
Score = 275 bits (704), Expect = 5e-72
Identities = 189/511 (36%), Positives = 267/511 (51%), Gaps = 8/511 (1%)
Frame = +2
Query: 2255 QCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYR 2434
Q ++ + T R+R + +L++DA YFD S G ++T L + + + +
Sbjct: 120 QHAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSV--STGHLSTVLNDNLERFREVFNEK 177
Query: 2435 LGSIFNAIASVGGGLGIAFYYGWQMA----FLVMAIFPFMAVGQALMMKYHGGSATSDAK 2602
+ I + G +AFY W++A F + I + A +MK G T A
Sbjct: 178 IALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYA- 236
Query: 2603 EMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAII----RGLTYGF 2770
NAG A + + +TV +L Q + L A I +A++ RG+TY F
Sbjct: 237 ---NAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFF 293
Query: 2771 ANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKAT 2950
NS+ V+ + A GT+ A +
Sbjct: 294 CNSLN-------------------------TVVLYVGATMIYSGTLETAVVVRDD----- 323
Query: 2951 FAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPG 3130
N++E++ T +++G + V F YP RP +L+G++ V+ G
Sbjct: 324 -------NVIEKDE-----TDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNG 371
Query: 3131 QTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILF 3310
+ +ALVG SG GKSTV+ LL Y+ G + +D DL MN K LR+ I +VSQEP+LF
Sbjct: 372 ECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLF 431
Query: 3311 DTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQR 3490
+T+I ENI +G + +I A KAN + F+ P G +T VGE+GTQLSGGQKQR
Sbjct: 432 NTTIEENIRFGNP--NVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQR 489
Query: 3491 IAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCI 3670
IAIAR L+RNPKILLLDEATSALD ESE+ VQ AL+ A++ RT IVVAHRLSTI NA I
Sbjct: 490 IAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKI 549
Query: 3671 MVVKNGQVVEQGTHNELIAKRGAYFALTQKQ 3763
+V++ G++VE G H+ELIAKRG Y L Q Q
Sbjct: 550 IVMQKGEIVEVGNHDELIAKRGVYNDLVQAQ 580
Score = 170 bits (431), Expect = 2e-40
Identities = 133/474 (28%), Positives = 218/474 (45%), Gaps = 6/474 (1%)
Frame = +2
Query: 80 DRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHE 259
D L + + S GV P+++ ++ + F +G L +SH
Sbjct: 653 DYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDML--------------YYSHL 698
Query: 260 VIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYDK-NTSG 436
L +++L + Q F + E+LS R R + F ++ A+YD N S
Sbjct: 699 W---ALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSA 755
Query: 437 T-LSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMIC 613
T LSN+L + V+ D++G + A Y W +TL ++ P + +
Sbjct: 756 TRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPLLYLA 815
Query: 614 GLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTG 793
+ + A E L ++RTV A N ++ + L+ K+
Sbjct: 816 EYCYEAATETAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSY 875
Query: 794 IKKSFLIGA--GLA-SFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMAL 964
K++ + GA GL+ S F+ +Y+ ++F GT + V ++ M +
Sbjct: 876 FKRAIIQGAANGLSLSCFLFVYS---VSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMA 932
Query: 965 GQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRA 1144
G A A+ AA ++ + + S++G+ + G I V+F Y R
Sbjct: 933 GSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIE-KGEIIGENVQFHYDQRP 991
Query: 1145 DVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKY 1324
D IL GV+L PG+T+ALVG SGCGKSTII LL+RFY+ G++ ID +ED N+ +
Sbjct: 992 DRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNH 1051
Query: 1325 LRQLVGVVSQEPNLFNTSIEQNIRYGRS-DVSDEDIARALKEANAADFIKTFPE 1483
LR + +VSQEP LFN SI +N+ YG + V ++ +AL+ ANA +F+ FP+
Sbjct: 1052 LRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQ 1105
>gi|27368845|emb|CAD59580.1| MDR-like ABC transporter [Oryza sativa
(japonica cultivar-group)]
Length = 1349
Score = 714 bits (1843), Expect = 0.0
Identities = 432/1276 (33%), Positives = 670/1276 (51%), Gaps = 34/1276 (2%)
Frame = +2
Query: 53 QLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKA 232
QL+ + +D +++ +G + + G L + ++ +F A
Sbjct: 83 QLFSFGDGLDYVLMTLGTLGALVHGCSLTVFLRFFADLVDSF--------------GSHA 128
Query: 233 AARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIA 412
A V++ ++ +G I+A+ + + SC+M E+ S R R ++ H+ + Q+++
Sbjct: 129 AHPDTMLRLVVKYAFYFLVVGAAIWASSWAEISCWMWTGERQSTRMRIRYLHAALHQDVS 188
Query: 413 WYDKNT-SGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMS 589
++D + + + + + + V++ +K+G +A F+ GF V FT W L L+ ++
Sbjct: 189 FFDTDVRTSDVIHAINADAVVVQDAISEKLGNLIHYLATFVSGFVVGFTAAWQLALVTLA 248
Query: 590 LSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDA 769
+ P + + G + A GIAE+ L IR V +F G+E + Y A
Sbjct: 249 VVPLIAVIGGLSAAALAKLSSRSQDALSDASGIAEQALAQIRIVQSFVGEERVMRAYSAA 308
Query: 770 LEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMM 949
L ++ G + F G GL + ++ Y L W G + V G + FSVM+
Sbjct: 309 LAVAQRIGYRSGFAKGIGLGGTYFTVFCCYALLLWYGGHLVRRAHTNGGLAIATMFSVMI 368
Query: 950 GSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFT 1129
G +ALGQ+ A A AAA ++ +++ P ++ G ++GR+ + VEF+
Sbjct: 369 GGLALGQSAPSMAAFAKARVAAAKIFRMMEHKPSMEREG--GVELEAVTGRVELRDVEFS 426
Query: 1130 YPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIED 1309
YP+R DV IL+G+SL G+T+ALVGSSG GKST++ L++RFY P+AG IL+D + D
Sbjct: 427 YPSRPDVGILRGLSLSVPAGKTIALVGSSGSGKSTVVSLIERFYEPNAGTILLDGHDLRD 486
Query: 1310 FNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEGL 1489
N+++LR+ +G+VSQEP LF T+I +N+ GR + E++ A + ANA FI P+
Sbjct: 487 LNLRWLRRQIGLVSQEPALFATTIRENLLLGRDGATQEELEEAARVANAHSFIVKLPDAY 546
Query: 1490 NT-------------------LVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSAL 1612
NT VG+RG+Q+SGGQKQRIAIARA++RNP ILLLDEATSAL
Sbjct: 547 NTQARPGGNQWVAFERCSELVQVGERGLQLSGGQKQRIAIARAMLRNPAILLLDEATSAL 606
Query: 1613 DAESESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQ-KG 1789
D+ESE +VQ AL+ GRTT+VIAHRLST+R AD + V++ G + EVGTH+ L+ + G
Sbjct: 607 DSESEKLVQEALDRFMIGRTTLVIAHRLSTIRKADLVAVLQGGAISEVGTHDELMARGDG 666
Query: 1790 LYHELVHAQVFADVDDKPKKKEAERRMSRQTSQRKGSV-------NFKTQESQVDXXXXX 1948
Y L+ Q A A RR S + S + SV N S
Sbjct: 667 TYARLIRMQEQA----HEAALVAARRSSARPSSARNSVSSPIITRNSSYGRSPYSRRLSD 722
Query: 1949 XXXXXXXXXXXXXXXXXXXXXGAVKANLF-KILRYARPEWIYXXXXXXXXLIQGAVMPAF 2125
V+A+ F ++ + PEW Y ++ G+ F
Sbjct: 723 ADFITGLGLGVDSKQQQQQHYFRVQASSFWRLAKMNSPEWGYALVASLGSMVCGSFSAIF 782
Query: 2126 SLFFSQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIR 2305
+ S +++V+ PD M + + + + +++ Q + E LT R+R
Sbjct: 783 AYVLSAVLSVYYAPDAAYMDRQIAKYCYLLIGMSSAALLFNTVQHLFWDTVGENLTKRVR 842
Query: 2306 SKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGI 2485
++ VLR + +FDM +S RI RLA DA N++SAI R+ I A +
Sbjct: 843 ERMLAAVLRNEIAWFDMEDNSSARIAARLALDAQNVRSAIGDRISIIVQNSALMLVACTA 902
Query: 2486 AFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQA 2665
F W++A +++A+FP + L + G + + A + A EA+ N+RTV A
Sbjct: 903 GFVLQWRLALVLLAVFPLVVAATVLQKMFLKGFSGDLERAHARATQIAGEAVANVRTVAA 962
Query: 2666 LTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNV 2845
+ K+ +F ++L P K I G YG A + + +YA + +L+ K+
Sbjct: 963 FGSEAKIVGLFEANLAGPLRRCFWKGQIAGSGYGVAQFLLYASYALGLWYAAWLV--KHG 1020
Query: 2846 LMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRI--DGMTSSG 3019
+ + +RV + S + P+++K A +F ++ I D + ++
Sbjct: 1021 VSDFSKTIRVFMVLMVSANGAAETLTLAPDFVKGGRAMQAVFEAMDRRTEIEPDDVDAAA 1080
Query: 3020 TYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERL 3199
+ GEV+L V F YP RP V + + L++ + G+TLALVG SGCGKS+V++L++R
Sbjct: 1081 VPERPRGEVELKHVDFAYPSRPEVQVFRDLSLRARAGRTLALVGASGCGKSSVLALVQRF 1140
Query: 3200 YDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIE 3379
Y+P G V +D DLR+ N + LR+ +ALV QEP LF +I +NI YG + T ++
Sbjct: 1141 YEPNSGRVLLDGRDLRKFNLRSLRRAMALVPQEPFLFAATIHDNIAYGREGA--TEAEVV 1198
Query: 3380 TACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSAL 3559
A + AN HKFI LP+GY T VGE+G QLSGGQ+QRIAIARAL++ ILLLDEATSAL
Sbjct: 1199 EAATAANAHKFISALPEGYGTLVGERGVQLSGGQRQRIAIARALVKQAPILLLDEATSAL 1258
Query: 3560 DTESEKQVQVAL-DAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKR- 3733
D ESE+ VQ AL ++ RT IVVAHRL+T+ NA I V+ +G+V EQG+H+ L+
Sbjct: 1259 DAESERSVQEALASSSGSGRTTIVVAHRLATVRNAHTIAVIDDGKVAEQGSHSHLLNHHP 1318
Query: 3734 -GAYFALTQKQSSNQS 3778
G Y + Q Q + S
Sbjct: 1319 DGCYARMLQLQRLSHS 1334
>gi|15232977|ref|NP_189479.1| P-glycoprotein, putative [Arabidopsis
thaliana]
gi|9294573|dbj|BAB02854.1| multidrug resistance p-glycoprotein; ABC
transporter-like protein [Arabidopsis thaliana]
Length = 1240
Score = 711 bits (1836), Expect = 0.0
Identities = 437/1250 (34%), Positives = 678/1250 (53%), Gaps = 14/1250 (1%)
Frame = +2
Query: 44 SIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTAS 223
SI ++ + VD +++A+G+I + G P++ I + N LGT S+++
Sbjct: 19 SIRSIFMHADGVDWILMALGLIGAVGDGFITPVVVFIFNTLLNN---LGT------SSSN 69
Query: 224 EKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQ 403
K F + +N + +Y+ CG + FL+ C+ E+ + R R ++ +V+RQ
Sbjct: 70 NKT-----FMQTISKNVVALLYVACGSWVICFLEGYCWTRTGERQAARMREKYLRAVLRQ 124
Query: 404 EIAWYD---KNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLT 574
++ ++D +TS +++ D+L +++ +K+ + F+ + V+F W LT
Sbjct: 125 DVGYFDLHVTSTSDVITSISSDSLV-IQDFLSEKLPNFLMNASAFVASYIVSFILMWRLT 183
Query: 575 LIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECK 754
++ +++ GL QY AG IAE+ ++S+RTV AF +
Sbjct: 184 IVGFPFIILLLVPGLMYGRALVSISRKIHEQYNEAGSIAEQAISSVRTVYAFGSENKMIG 243
Query: 755 RYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVF 934
++ AL K G+++ G + S V +A + W G+ V + + GTV V
Sbjct: 244 KFSTALRGSVKLGLRQGLAKGITIGSNGVT-HAIWAFLTWYGSRLVMNHGSKGGTVFVVI 302
Query: 935 FSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVN 1114
+ G ++LGQ+ A A + EVI R+P+ID+ EGQ ++ G + N
Sbjct: 303 SCITYGGVSLGQSLSNLKYFSEAFVAWERILEVIKRVPDIDSNKKEGQILERMKGEVEFN 362
Query: 1115 KVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDD 1294
V+FTY +R + I + L G+TVALVG SG GKST+I LLQRFY+P AG+ILID
Sbjct: 363 HVKFTYLSRPETTIFDDLCLKIPAGKTVALVGGSGSGKSTVISLLQRFYDPIAGEILIDG 422
Query: 1295 IPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKT 1474
+ I+ + +LR +G+VSQEP LF TSI +NI +G+ D S +++ A K +NA FI
Sbjct: 423 VSIDKLQVNWLRSQMGLVSQEPVLFATSITENILFGKEDASLDEVVEAAKASNAHTFISQ 482
Query: 1475 FPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALEN 1654
FP G T VG+RGVQMSGGQKQRIAIARA++++PKILLLDEATSALD+ESE +VQ +L+N
Sbjct: 483 FPLGYKTQVGERGVQMSGGQKQRIAIARAIIKSPKILLLDEATSALDSESERVVQESLDN 542
Query: 1655 ASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQ-KGLYHELVHAQVFADV 1831
AS GRTTIVIAHRLST+RNAD I V+ GQ++E G+HE L+++ G Y LV Q
Sbjct: 543 ASIGRTTIVIAHRLSTIRNADVICVIHNGQIVETGSHEELLKRIDGQYTSLVSLQ----- 597
Query: 1832 DDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXX 2011
+ + E ++ S K V +++ +
Sbjct: 598 ----QMENEESNVNINVSVTKDQVMSLSKDFKYSQHNSIGSTSSSIVTNVSDLIPNDNQ- 652
Query: 2012 GAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKD 2191
+ + +++ RPEW + + G + P + +I+VF DQ+K+
Sbjct: 653 -PLVPSFTRLMVMNRPEWKHALYGCLSAALVGVLQPVSAYSAGSVISVFFLTSHDQIKEK 711
Query: 2192 GHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSP 2371
+ L+F+ LA + Q F E LT RIR ++ +L + +FD+ +S
Sbjct: 712 TRIYVLLFVGLAIFSFLVNISQHYGFAYMGEYLTKRIREQMLSKILTFEVNWFDIDDNSS 771
Query: 2372 GRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAV- 2548
G I +RLA DA ++S + R+ + I++V I W++A +++++ P + V
Sbjct: 772 GAICSRLAKDANVVRSMVGDRMSLLVQTISAVIIACIIGLVIAWRLAIVMISVQPLIVVC 831
Query: 2549 --GQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPH 2722
Q +++K A +K + + K A EA+ NIRT+ A + Q ++ + + P
Sbjct: 832 FYTQRVLLKSLSEKA---SKAQDESSKLAAEAVSNIRTITAFSSQERIIKLLKKVQEGPR 888
Query: 2723 GGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFG 2902
++ ++ + G+ G + S+ T A F +G LI D + V + F I F
Sbjct: 889 RESVHRSWLAGIVLGTSRSLITCTSALNFWYGGRLIADGKI------VSKAFFEIFLIFV 942
Query: 2903 TIG----FAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSG-TYPQLSGEVKLNKVFF 3067
T G A + + + A G +F +L+ I+ G ++ G++ V F
Sbjct: 943 TTGRVIADAGTMTTDLARGLDAVGSVFAVLDRCTTIEPKNPDGYVAEKIKGQITFLNVDF 1002
Query: 3068 RYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLR 3247
YP RP V I + ++ + G++ A+VG SG GKST+I L+ER YDPL+G V +D D+R
Sbjct: 1003 AYPTRPDVVIFENFSIEIDEGKSTAIVGTSGSGKSTIIGLIERFYDPLKGTVKIDGRDIR 1062
Query: 3248 QMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELP 3427
+ + LRK+I+LVSQEP+LF +IRENI+YG + +I A AN H FI L
Sbjct: 1063 SYHLRSLRKYISLVSQEPMLFAGTIRENIMYGGTSDKIDESEIIEAAKAANAHDFITSLS 1122
Query: 3428 DGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAA 3607
+GY+T G+KG QLSGGQKQRIAIARA+++NP +LLLDEATSALD++SE+ VQ AL+
Sbjct: 1123 NGYDTNCGDKGVQLSGGQKQRIAIARAVLKNPSVLLLDEATSALDSKSERVVQDALERVM 1182
Query: 3608 KDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAK--RGAYFAL 3751
RT I++AHRLSTI N I+V+ G++VE GTH+ L+ K G YF+L
Sbjct: 1183 VGRTSIMIAHRLSTIQNCDMIVVLGKGKIVESGTHSSLLEKGPTGTYFSL 1232
Score = 340 bits (871), Expect = 2e-91
Identities = 197/533 (36%), Positives = 300/533 (55%), Gaps = 11/533 (2%)
Frame = +2
Query: 251 SHEVIQNCLK-YVYLGCGIFAAGFL----QASCFMVICEKLSNRFRRQFFHSVMRQEIAW 415
SH+ I+ + YV L G+ FL Q F + E L+ R R Q ++ E+ W
Sbjct: 704 SHDQIKEKTRIYVLLFVGLAIFSFLVNISQHYGFAYMGEYLTKRIREQMLSKILTFEVNW 763
Query: 416 YD--KNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMS 589
+D N+SG + ++L + VR GD++ L Q ++ I + W L ++M+S
Sbjct: 764 FDIDDNSSGAICSRLAKDANVVRSMVGDRMSLLVQTISAVIIACIIGLVIAWRLAIVMIS 823
Query: 590 LSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDA 769
+ P +++C + +A E +++IRT+ AF+ QE K +
Sbjct: 824 VQPLIVVCFYTQRVLLKSLSEKASKAQDESSKLAAEAVSNIRTITAFSSQERIIKLLKKV 883
Query: 770 LEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMM 949
E ++ + +S+L G L + +I + L FW G + G++ S +F +
Sbjct: 884 QEGPRRESVHRSWLAGIVLGTSRSLITCTSALNFWYGGRLIADGKIVSKAFFEIFLIFVT 943
Query: 950 GSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFT 1129
+ AG + L A S++ V+DR I+ + +G KI G+I+ V+F
Sbjct: 944 TGRVIADAGTMTTDLARGLDAVGSVFAVLDRCTTIEPKNPDGYVAEKIKGQITFLNVDFA 1003
Query: 1130 YPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIED 1309
YPTR DV I + S++ G++ A+VG+SG GKSTII L++RFY+P G + ID I
Sbjct: 1004 YPTRPDVVIFENFSIEIDEGKSTAIVGTSGSGKSTIIGLIERFYDPLKGTVKIDGRDIRS 1063
Query: 1310 FNIKYLRQLVGVVSQEPNLFNTSIEQNIRY-GRSDVSDE-DIARALKEANAADFIKTFPE 1483
++++ LR+ + +VSQEP LF +I +NI Y G SD DE +I A K ANA DFI +
Sbjct: 1064 YHLRSLRKYISLVSQEPMLFAGTIRENIMYGGTSDKIDESEIIEAAKAANAHDFITSLSN 1123
Query: 1484 GLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASR 1663
G +T GD+GVQ+SGGQKQRIAIARA+++NP +LLLDEATSALD++SE +VQ ALE
Sbjct: 1124 GYDTNCGDKGVQLSGGQKQRIAIARAVLKNPSVLLLDEATSALDSKSERVVQDALERVMV 1183
Query: 1664 GRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQ--KGLYHELVHAQ 1816
GRT+I+IAHRLST++N D I+V+ G+++E GTH +L+E+ G Y L Q
Sbjct: 1184 GRTSIMIAHRLSTIQNCDMIVVLGKGKIVESGTHSSLLEKGPTGTYFSLAGIQ 1236
Score = 303 bits (776), Expect = 2e-80
Identities = 203/583 (34%), Positives = 312/583 (52%), Gaps = 15/583 (2%)
Frame = +2
Query: 2060 EWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQG 2239
+WI + G + P F+ ++N + + +L G
Sbjct: 31 DWILMALGLIGAVGDGFITPVVVFIFNTLLNNLGTSSSNNKTFMQTISKNVVALLYVACG 90
Query: 2240 TSMLFQCSLFGVA----AERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAP 2407
+ ++ C L G ER R+R K R VLRQD YFD+ S + T +++D+
Sbjct: 91 SWVI--CFLEGYCWTRTGERQAARMREKYLRAVLRQDVGYFDLHVTSTSDVITSISSDSL 148
Query: 2408 NIKSAIDYRLGS-IFNAIASVGGGLGIAFYYGWQMA-----FLVMAIFPFMAVGQALMM- 2566
I+ + +L + + NA A V + ++F W++ F+++ + P + G+AL+
Sbjct: 149 VIQDFLSEKLPNFLMNASAFVASYI-VSFILMWRLTIVGFPFIILLLVPGLMYGRALVSI 207
Query: 2567 --KYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISK 2740
K H ++ AG A +AI ++RTV A + K+ F + L + +
Sbjct: 208 SRKIH--------EQYNEAGSIAEQAISSVRTVYAFGSENKMIGKFSTALRGSVKLGLRQ 259
Query: 2741 AIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAA 2920
+ +G+T G +N + +A +G L+ + + V V+ I++ ++G +
Sbjct: 260 GLAKGITIG-SNGVTHAIWAFLTWYGSRLVMNHG--SKGGTVFVVISCITYGGVSLGQSL 316
Query: 2921 SYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTY-PQLSGEVKLNKVFFRYPERPAVPI 3097
S + +A A I +++ P ID G ++ GEV+ N V F Y RP I
Sbjct: 317 SNLKYFSEAFVAWERILEVIKRVPDIDSNKKEGQILERMKGEVEFNHVKFTYLSRPETTI 376
Query: 3098 LQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKH 3277
L + + G+T+ALVG SG GKSTVISLL+R YDP+ G + +D + ++ LR
Sbjct: 377 FDDLCLKIPAGKTVALVGGSGSGKSTVISLLQRFYDPIAGEILIDGVSIDKLQVNWLRSQ 436
Query: 3278 IALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEK 3457
+ LVSQEP+LF TSI ENI++G + +++ A +N H FI + P GY+T+VGE+
Sbjct: 437 MGLVSQEPVLFATSITENILFGKEDASL--DEVVEAAKASNAHTFISQFPLGYKTQVGER 494
Query: 3458 GTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAH 3637
G Q+SGGQKQRIAIARA+I++PKILLLDEATSALD+ESE+ VQ +LD A+ RT IV+AH
Sbjct: 495 GVQMSGGQKQRIAIARAIIKSPKILLLDEATSALDSESERVVQESLDNASIGRTTIVIAH 554
Query: 3638 RLSTIVNAGCIMVVKNGQVVEQGTHNELIAK-RGAYFALTQKQ 3763
RLSTI NA I V+ NGQ+VE G+H EL+ + G Y +L Q
Sbjct: 555 RLSTIRNADVICVIHNGQIVETGSHEELLKRIDGQYTSLVSLQ 597
>gi|16304396|gb|AAL15148.1| multidrug resistance transporter-like
protein [Pseudopleuronectes americanus]
Length = 817
Score = 708 bits (1828), Expect = 0.0
Identities = 377/798 (47%), Positives = 512/798 (63%), Gaps = 3/798 (0%)
Frame = +2
Query: 1379 IEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIAR 1558
+ +NIRYGR DV+ ++I +A KEANA DFI P+ +TLVGDRG QMSGGQKQR+AIAR
Sbjct: 16 LSENIRYGRLDVTQQEIEQAAKEANAYDFIMKLPQKFDTLVGDRGTQMSGGQKQRVAIAR 75
Query: 1559 ALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKA 1738
ALVRNPKILLLDEATSALDAESE+IVQ+AL+ GRTTI++AHRLST+RNAD I +
Sbjct: 76 ALVRNPKILLLDEATSALDAESETIVQAALDKVRLGRTTIIVAHRLSTIRNADVIAGFQD 135
Query: 1739 GQVMEVGTHETLIEQKGLYHELVHAQVFADVDDKPKKKE--AERRMSRQTSQRKGSVNFK 1912
G+V EVGTH L+E+KG+YH LV Q F DV++ K++E + S ++
Sbjct: 136 GKVAEVGTHSQLMEKKGIYHRLVTTQTFQDVEEGEKEEEELSVDEKSPLVDSHSECTPYR 195
Query: 1913 TQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXX 2092
+ ++ + FK+LR PEW Y
Sbjct: 196 RKTTRGSSMTVSEGGKEEKEKTESDKDEPEEDEIVPPVSFFKVLRLNLPEWPYILVGTIC 255
Query: 2093 XLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFG 2272
+I GA+ P F++ FS+II VF+ D++ +++ ++LMF V+ V +M Q FG
Sbjct: 256 AIINGAMQPVFAIIFSKIITVFAETDQELVRQRATLFSLMFAVIGGVSFVTMFLQGFCFG 315
Query: 2273 VAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFN 2452
+ E LT+++R ++ ++RQD +FD PK+S G +TTRLATDA ++ A R+ ++
Sbjct: 316 KSGEILTLKLRLGAFKAMMRQDLGWFDNPKNSVGALTTRLATDAAQVQGATGVRMATLAQ 375
Query: 2453 AIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAM 2632
A++G + I+F YGW++ L++A+ P M + A+ MK G A D KE+E AGK +
Sbjct: 376 NFANMGTSVIISFVYGWELTLLILAVVPAMVLAGAVEMKLLTGHAVEDKKELEKAGKIST 435
Query: 2633 EAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFR 2812
EAIENIRTV +LT + K +++ +L+ P+ + KA + GLT+ F+ ++ +F YA FR
Sbjct: 436 EAIENIRTVASLTREPKFESLYHENLEVPYKNSTKKAHVYGLTFAFSQAMIYFAYAGCFR 495
Query: 2813 FGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEP 2992
FG +LI + M+ + V V+ + + IG A S+ P Y KA +A + ++ EP
Sbjct: 496 FGAWLIEEGR--MDVQGVFLVISTVLYGAMAIGEANSFTPNYAKAKMSASYLMQLINLEP 553
Query: 2993 RIDGMTSSGTYPQ-LSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGK 3169
ID ++ G P G V V F YP RP VPILQGL++ VK G+TLALVG SGCGK
Sbjct: 554 AIDNLSQEGETPDSFDGNVHFENVRFNYPSRPDVPILQGLDLEVKRGETLALVGSSGCGK 613
Query: 3170 STVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQ 3349
ST+I LLER YDP EG+V +DN + +++N LR + +VSQEP LFD ++ +NI YG
Sbjct: 614 STIIQLLERFYDPREGSVALDNVNTKRLNIHWLRSQMGIVSQEPTLFDCTLAQNIAYGDN 673
Query: 3350 PGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKI 3529
T ++I A ANIH FI ELP+ Y+T+ G+KGTQLSGGQKQRIAIARA++RNP +
Sbjct: 674 SRIATMDEIVAAAKSANIHSFIQELPEKYDTQAGDKGTQLSGGQKQRIAIARAILRNPML 733
Query: 3530 LLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGT 3709
LLLDEATSALDTESEK VQ ALD A+K RTCI+VAHRLSTI NA I V++ G VVEQGT
Sbjct: 734 LLLDEATSALDTESEKVVQEALDQASKGRTCIIVAHRLSTIQNADRIAVLQGGVVVEQGT 793
Query: 3710 HNELIAKRGAYFALTQKQ 3763
H +L+AKRG Y L Q
Sbjct: 794 HQQLLAKRGVYHMLVTTQ 811
Score = 388 bits (996), Expect = e-106
Identities = 224/580 (38%), Positives = 331/580 (56%), Gaps = 4/580 (0%)
Frame = +2
Query: 92 LAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHEVIQN 271
+ VG I + G P+ +II + T+F + T E RA
Sbjct: 249 ILVGTICAIINGAMQPVFAIIFSKII-------TVFAE---TDQELVRQRATLFS----- 293
Query: 272 CLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYD--KNTSGTLS 445
L + +G F FLQ CF E L+ + R F ++MRQ++ W+D KN+ G L+
Sbjct: 294 -LMFAVIGGVSFVTMFLQGFCFGKSGEILTLKLRLGAFKAMMRQDLGWFDNPKNSVGALT 352
Query: 446 NKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFX 625
+L + +V+ TG ++ Q A ++F Y W LTL+++++ P M++ G
Sbjct: 353 TRLATDAAQVQGATGVRMATLAQNFANMGTSVIISFVYGWELTLLILAVVPAMVLAGAVE 412
Query: 626 XXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKS 805
+ AG I+ E + +IRTV + + Y + LE K KK+
Sbjct: 413 MKLLTGHAVEDKKELEKAGKISTEAIENIRTVASLTREPKFESLYHENLEVPYKNSTKKA 472
Query: 806 FLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQF 985
+ G A +IY +Y F G + GR++ V V +V+ G+MA+G+A
Sbjct: 473 HVYGLTFAFSQAMIYFAYAGCFRFGAWLIEEGRMDVQGVFLVISTVLYGAMAIGEANSFT 532
Query: 986 ATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKG 1165
A +A+ L ++I+ P ID S EG+TP G + V F YP+R DV IL+G
Sbjct: 533 PNYAKAKMSASYLMQLINLEPAIDNLSQEGETPDSFDGNVHFENVRFNYPSRPDVPILQG 592
Query: 1166 VSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGV 1345
+ L+ + G+T+ALVGSSGCGKSTIIQLL+RFY+P G + +D++ + NI +LR +G+
Sbjct: 593 LDLEVKRGETLALVGSSGCGKSTIIQLLERFYDPREGSVALDNVNTKRLNIHWLRSQMGI 652
Query: 1346 VSQEPNLFNTSIEQNIRYGRSD--VSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQ 1519
VSQEP LF+ ++ QNI YG + + ++I A K AN FI+ PE +T GD+G Q
Sbjct: 653 VSQEPTLFDCTLAQNIAYGDNSRIATMDEIVAAAKSANIHSFIQELPEKYDTQAGDKGTQ 712
Query: 1520 MSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLS 1699
+SGGQKQRIAIARA++RNP +LLLDEATSALD ESE +VQ AL+ AS+GRT I++AHRLS
Sbjct: 713 LSGGQKQRIAIARAILRNPMLLLLDEATSALDTESEKVVQEALDQASKGRTCIIVAHRLS 772
Query: 1700 TVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQV 1819
T++NAD+I V++ G V+E GTH+ L+ ++G+YH LV Q+
Sbjct: 773 TIQNADRIAVLQGGVVVEQGTHQQLLAKRGVYHMLVTTQM 812
Score = 157 bits (396), Expect = 2e-36
Identities = 84/149 (56%), Positives = 107/149 (71%)
Frame = +2
Query: 3320 IRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAI 3499
+ ENI YG + T ++IE A +AN + FI +LP ++T VG++GTQ+SGGQKQR+AI
Sbjct: 16 LSENIRYGRL--DVTQQEIEQAAKEANAYDFIMKLPQKFDTLVGDRGTQMSGGQKQRVAI 73
Query: 3500 ARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVV 3679
ARAL+RNPKILLLDEATSALD ESE VQ ALD RT I+VAHRLSTI NA I
Sbjct: 74 ARALVRNPKILLLDEATSALDAESETIVQAALDKVRLGRTTIIVAHRLSTIRNADVIAGF 133
Query: 3680 KNGQVVEQGTHNELIAKRGAYFALTQKQS 3766
++G+V E GTH++L+ K+G Y L Q+
Sbjct: 134 QDGKVAEVGTHSQLMEKKGIYHRLVTTQT 162
>gi|38345252|emb|CAD41096.2| OSJNBb0011N17.13 [Oryza sativa (japonica
cultivar-group)]
Length = 1271
Score = 707 bits (1826), Expect = 0.0
Identities = 430/1274 (33%), Positives = 675/1274 (52%), Gaps = 34/1274 (2%)
Frame = +2
Query: 44 SIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTAS 223
S +L RY DR ++A+G++ S G+ PL +++G++ ++ A
Sbjct: 8 SFLRLVRYADAHDRCLMALGVLGSFGDGMMQPLSMLVLGDIVNSY-----------GGAG 56
Query: 224 EKAAARAEFSHEVIQN-CLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
+AR+ FS + L+ +Y+ + A FL+ C+ E+ +++ RR + +V+
Sbjct: 57 GAGSARSAFSSGAVDKFALRLLYVAVAVGACSFLEGLCWTRTAERQASKMRRLYLEAVLS 116
Query: 401 QEIAWYDKNTSGTLS-------------NKLFDNLERVREGTGDKVGLAFQMMAQFIGGF 541
QE+A++D S S + + D+ + +++ G+K+ + F G
Sbjct: 117 QEVAFFDAAPSSPSSPQAQAQATTFRVISTVSDDADAIQDFLGEKLPMVLANATLFFGAL 176
Query: 542 AVAFTYDWLLTL------IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVL 703
AV+F + W L L +++ ++P +++ G Y AGGIA++ +
Sbjct: 177 AVSFVFAWRLALAGLPFTLLLFVTPSVLLAGRMAAAAGEARAA-----YEEAGGIAQQAV 231
Query: 704 TSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGT 883
+SIRTV ++ + +R+ A+ G+++ + GA + S VI YA + W+G+
Sbjct: 232 SSIRTVASYTAERRTVERFRGAVARSAALGVRQGLIKGAVIGSMGVI-YAVWSFLSWIGS 290
Query: 884 NFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAY 1063
V + G V +++ M++ A A AA+ + E+I+ +P ++
Sbjct: 291 LLVIHLHAQGGHVFVASICIVLAGMSIMMALPNLRYFIDATAAASRMQEMIEMLPPLEGA 350
Query: 1064 STEGQTPSKISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQ 1243
+G T +I G I V F+YP+R D +L G +L G TV LVG SG GKST+I
Sbjct: 351 EKKGATMERIRGEIVFKDVHFSYPSRPDTLVLNGFNLTISEGATVGLVGGSGSGKSTVIS 410
Query: 1244 LLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDE 1423
LLQRFY+PD+G+I +DD I+ N+++LR +G+VSQEP LF TSI +NI +G S +
Sbjct: 411 LLQRFYSPDSGEISMDDHGIDTLNVEWLRSQIGLVSQEPVLFATSIRENILFGDETASLK 470
Query: 1424 DIARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEAT 1603
+ A K ANA +FI P G T VG G Q+SGGQKQRIAIARALVR+P+ILLLDEAT
Sbjct: 471 QVVAAAKMANAHEFIVKLPHGYETHVGQFGTQLSGGQKQRIAIARALVRDPRILLLDEAT 530
Query: 1604 SALDAESESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLI-- 1777
SALDAESE VQ AL+ AS GRTT+++AHRLST+R AD I V+ AG+V+E GTH+ L+
Sbjct: 531 SALDAESERTVQDALDRASVGRTTVIVAHRLSTLRKADTIAVLDAGRVVEAGTHDELLGM 590
Query: 1778 ---EQKGLYHELVHAQVFADVDDKPKKKEA-ERRMSRQTSQRKGSVNFKTQESQVDXXXX 1945
+ G+Y +VH Q V + ++ A + S S R + ++
Sbjct: 591 DDGGEGGVYARMVHLQKAPPVAAREERHRAVDVVESEMVSFRSVEIMSAVSATEHRPSPA 650
Query: 1946 XXXXXXXXXXXXXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAF 2125
+ K + ++L+ RPEW ++ GAV+P +
Sbjct: 651 PSFCSVEHSTEIGRKLVDHGVARSRKPSKLRLLKMNRPEWKQALLGCVGAVVFGAVLPLY 710
Query: 2126 SLFFSQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIR 2305
S + V+ D Q++ + +FL +A V T+ + Q F V ERLT R+R
Sbjct: 711 SYSLGSLPEVYFLADDGQIRSKTRLYYFLFLGIAVVCITANIVQHYNFAVMGERLTERVR 770
Query: 2306 SKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGI 2485
++ +L + +FD ++S + RLAT + ++S + R+ + A A+ G +
Sbjct: 771 GQMLAKILSFEVGWFDEDENSSAAVCARLATQSSKVRSLVGDRMCLLVQAGATASLGFSL 830
Query: 2486 AFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAG-KTAMEAIENIRTVQ 2662
A W++A ++MA+ P + + K + + AK+ + G + A EA+ N RT+
Sbjct: 831 ALAVSWRLATVMMAMQP-LIIASFYFKKVLMAAMSKKAKKAQVQGSQLASEAVVNHRTIT 889
Query: 2663 ALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKN 2842
A + Q ++ ++ + P N++ + G + A A +G L+
Sbjct: 890 AFSSQRRMLRLYEAAQQGPKKDNVAHSWFSGFCLCLCQFSNTGSMAVALWYGGKLM--AK 947
Query: 2843 VLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRI-----DGM 3007
L+ P ++ +V F + I A S + + A + + L+ EP I D
Sbjct: 948 GLITPTHLFQVFFMLMTMGRVIADAGSLTSDLAQGGDAVRSVLDTLDREPTIKDDDNDNE 1007
Query: 3008 TSSGTYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISL 3187
++ G ++ V F YP RP V +L G ++ + G+T+ALVGPSG GKSTVI L
Sbjct: 1008 RKKKKRKEIKGAIEFKNVHFSYPTRPEVAVLAGFSLEIGAGKTVALVGPSGSGKSTVIGL 1067
Query: 3188 LERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTH 3367
+ER YD G+V VD D+R + LR +ALVSQEP LF +IR+NI YG T
Sbjct: 1068 IERFYDAQRGSVLVDGEDIRSYSLARLRSQVALVSQEPTLFSGTIRDNIAYGAAEEHATE 1127
Query: 3368 EQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEA 3547
+++ A + AN H FI + GY+TRVGE+G QLSGGQ+QRIA+ARA++++ +ILLLDEA
Sbjct: 1128 DEVARAAALANAHGFISAMERGYDTRVGERGAQLSGGQRQRIALARAVLKDARILLLDEA 1187
Query: 3548 TSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIA 3727
TSALD SE+ VQ A+D + RTC+VVAHRLST+ + I VVK+G+V E+G H+EL+A
Sbjct: 1188 TSALDAASERLVQDAVDRMLRGRTCVVVAHRLSTVEKSDTIAVVKDGRVAERGRHHELLA 1247
Query: 3728 --KRGAYFALTQKQ 3763
+ G Y+ L + Q
Sbjct: 1248 VGRAGTYYNLIKLQ 1261
>gi|9294571|dbj|BAB02852.1| multidrug resistance p-glycoprotein; ABC
transporter-like protein [Arabidopsis thaliana]
Length = 1228
Score = 704 bits (1816), Expect = 0.0
Identities = 428/1250 (34%), Positives = 665/1250 (52%), Gaps = 10/1250 (0%)
Frame = +2
Query: 44 SIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTAS 223
S+ ++ + VD +++ +G+I + G P++ I + +F + F D
Sbjct: 6 SMRSIFMHADGVDWMLMGLGLIGAVGDGFITPILFFITAMLLNDFGSFS--FNDET---- 59
Query: 224 EKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQ 403
F + +N L +Y+ C + FL+ C+ E+ + + R ++ +V+RQ
Sbjct: 60 --------FMQPISKNALAMLYVACASWVICFLEGYCWTRTGERQAAKMRERYLRAVLRQ 111
Query: 404 EIAWYD---KNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLT 574
++ ++D +TS +++ D+L +++ +K+ + F+G + V F W LT
Sbjct: 112 DVGYFDLHVTSTSDIITSVSSDSLV-IQDFLSEKLPNILMNASAFVGSYIVGFMLLWRLT 170
Query: 575 LIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECK 754
++ ++I GL +Y AG IAE+ ++S+RTV AF ++ +
Sbjct: 171 IVGFPFIILLLIPGLMYGRALIGISRKIREEYNEAGSIAEQAISSVRTVYAFVSEKKMIE 230
Query: 755 RYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVF 934
++ DAL+ K G+++ G + S I+YA + W G+ V + + GTV TV
Sbjct: 231 KFSDALQGSVKLGLRQGLAKGIAIGSNG-IVYAIWGFLTWYGSRMVMNYGYKGGTVSTVT 289
Query: 935 FSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVN 1114
V G ALGQA A A + ++I R+P+ID+ + G I G + N
Sbjct: 290 VCVTFGGTALGQALSNLKYFSEAFVAGERIQKMIKRVPDIDSDNLNGHILETIRGEVEFN 349
Query: 1115 KVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDD 1294
V+ YP+R + I + L G+TVALVG SG GKST+I LLQRFY+P+ G ILID
Sbjct: 350 NVKCKYPSRPETLIFDDLCLKIPSGKTVALVGGSGSGKSTVISLLQRFYDPNEGDILIDS 409
Query: 1295 IPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKT 1474
+ I + +K+LR +G+VSQEP+LF TSI++NI +G+ D S +++ A K +NA +FI
Sbjct: 410 VSINNMQVKWLRSQMGMVSQEPSLFATSIKENILFGKEDASFDEVVEAAKASNAHNFISQ 469
Query: 1475 FPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALEN 1654
FP G T VG+RGV MSGGQKQRIAIARAL+++P ILLLDEATSALD ESE +VQ AL+N
Sbjct: 470 FPHGYQTQVGERGVHMSGGQKQRIAIARALIKSPIILLLDEATSALDLESERVVQEALDN 529
Query: 1655 ASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVD 1834
AS GRTTIVIAHRLST+RNAD I V+ G ++E G+H+ L+E G Y LV Q
Sbjct: 530 ASVGRTTIVIAHRLSTIRNADIICVLHNGCIVETGSHDKLMEIDGKYTSLVRLQ------ 583
Query: 1835 DKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXG 2014
+ K E + ++G V+ + + +D
Sbjct: 584 ---QMKNEESCDNTSVGVKEGRVS--SLRNDLDYNPRDLAHSMSSSIVTNLSDSIPQDKK 638
Query: 2015 AVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDG 2194
+ + +++ RPEW + + GAV P ++ +I+VF + +Q+K++
Sbjct: 639 PLVPSFKRLMAMNRPEWKHALCGCLSASLGGAVQPIYAYSSGLMISVFFLTNHEQIKENT 698
Query: 2195 HFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPG 2374
+ L+F LA + + Q F E LT RIR ++ +L + +FD ++S G
Sbjct: 699 RIYVLLFFGLALFTFFTSISQQYSFSYMGEYLTKRIREQMLSKILTFEVNWFDEEENSSG 758
Query: 2375 RITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQ 2554
I +RLA DA ++S + R+ + I++V I W+ +++++ P + V
Sbjct: 759 AICSRLAKDANVVRSLVGERMSLLVQTISTVMVACTIGLVIAWRFTIVMISVQPVIIVCY 818
Query: 2555 ALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNI 2734
+ + + + K A EA+ NIRT+ + Q ++ + + P +
Sbjct: 819 YIQRVLLKNMSKKAIIAQDESSKLAAEAVSNIRTITTFSSQERIMKLLERVQEGPRRESA 878
Query: 2735 SKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGF 2914
++ + G+ G S+ T A F +G LI D + V + F + F T G
Sbjct: 879 RQSWLAGIMLGTTQSLITCTSALNFWYGGKLIADGKM------VSKAFFELFLIFKTTGR 932
Query: 2915 A----ASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSG-TYPQLSGEVKLNKVFFRYPE 3079
A + + K + + +F +L+ I+ G ++ G++ V F YP
Sbjct: 933 AIAEAGTMTTDLAKGSNSVDSVFTVLDRRTTIEPENPDGYILEKIKGQITFLNVDFAYPT 992
Query: 3080 RPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNP 3259
RP + I ++ + G++ A+VGPS GKSTVI L+ER YDPL+G V +D D+R +
Sbjct: 993 RPNMVIFNNFSIEIHEGKSTAIVGPSRSGKSTVIGLIERFYDPLQGIVKIDGRDIRSYHL 1052
Query: 3260 KHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYE 3439
+ LR+H++LVSQEP LF +IRENI+YG + +I A AN H+FI L DGY+
Sbjct: 1053 RSLRQHMSLVSQEPTLFAGTIRENIMYGRASNKIDESEIIEAGKTANAHEFITSLSDGYD 1112
Query: 3440 TRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRT 3619
T G++G QLSGGQKQRIAIAR +++NP ILLLDEATSALD++SE+ VQ AL+ +T
Sbjct: 1113 TYCGDRGVQLSGGQKQRIAIARTILKNPSILLLDEATSALDSQSERVVQDALEHVMVGKT 1172
Query: 3620 CIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAK--RGAYFALTQKQ 3763
+V+AHRLSTI N I V+ G+VVE GTH L+AK G+YF+L Q
Sbjct: 1173 SVVIAHRLSTIQNCDTIAVLDKGKVVESGTHASLLAKGPTGSYFSLVSLQ 1222
Score = 310 bits (795), Expect = 1e-82
Identities = 203/543 (37%), Positives = 296/543 (54%), Gaps = 11/543 (2%)
Frame = +2
Query: 2204 ALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRIT 2383
AL L +A + + ER ++R + R VLRQD YFD+ S I
Sbjct: 68 ALAMLYVACASWVICFLEGYCWTRTGERQAAKMRERYLRAVLRQDVGYFDLHVTSTSDII 127
Query: 2384 TRLATDAPNIKSAIDYRLGSIF-NAIASVGGGLGIAFYYGWQMA-----FLVMAIFPFMA 2545
T +++D+ I+ + +L +I NA A VG + + F W++ F+++ + P +
Sbjct: 128 TSVSSDSLVIQDFLSEKLPNILMNASAFVGSYI-VGFMLLWRLTIVGFPFIILLLIPGLM 186
Query: 2546 VGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHG 2725
G+AL+ G + +E AG A +AI ++RTV A + K+ F L
Sbjct: 187 YGRALI-----GISRKIREEYNEAGSIAEQAISSVRTVYAFVSEKKMIEKFSDALQ---- 237
Query: 2726 GNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLM----EPENVLRVLFAISF 2893
G++ + +GL G A YA +G + ++M + V V ++F
Sbjct: 238 GSVKLGLRQGLAKGIAIGSNGIVYAI---WGFLTWYGSRMVMNYGYKGGTVSTVTVCVTF 294
Query: 2894 SFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKLNKVFFR 3070
+G A S + +A A I M++ P ID +G + + GEV+ N V +
Sbjct: 295 GGTALGQALSNLKYFSEAFVAGERIQKMIKRVPDIDSDNLNGHILETIRGEVEFNNVKCK 354
Query: 3071 YPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQ 3250
YP RP I L + + G+T+ALVG SG GKSTVISLL+R YDP EG + +D+ +
Sbjct: 355 YPSRPETLIFDDLCLKIPSGKTVALVGGSGSGKSTVISLLQRFYDPNEGDILIDSVSINN 414
Query: 3251 MNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPD 3430
M K LR + +VSQEP LF TSI+ENI++G + + +++ A +N H FI + P
Sbjct: 415 MQVKWLRSQMGMVSQEPSLFATSIKENILFGKEDASF--DEVVEAAKASNAHNFISQFPH 472
Query: 3431 GYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAK 3610
GY+T+VGE+G +SGGQKQRIAIARALI++P ILLLDEATSALD ESE+ VQ ALD A+
Sbjct: 473 GYQTQVGERGVHMSGGQKQRIAIARALIKSPIILLLDEATSALDLESERVVQEALDNASV 532
Query: 3611 DRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSSNQSGGAF 3790
RT IV+AHRLSTI NA I V+ NG +VE G+H++L+ G Y +L + Q
Sbjct: 533 GRTTIVIAHRLSTIRNADIICVLHNGCIVETGSHDKLMEIDGKYTSLVRLQQMKNEESCD 592
Query: 3791 DTS 3799
+TS
Sbjct: 593 NTS 595
>gi|33307712|gb|AAQ03033.1| P-glycoprotein [Homo sapiens]
Length = 832
Score = 699 bits (1805), Expect = 0.0
Identities = 384/847 (45%), Positives = 528/847 (62%), Gaps = 1/847 (0%)
Frame = +2
Query: 1229 STIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRS 1408
ST++QLLQR Y+PD G I++D+ I N+++ R +GVVSQEP LF T+I NI+YGR
Sbjct: 3 STVVQLLQRLYDPDDGFIMVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRD 62
Query: 1409 DVSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILL 1588
DV+DE++ RA +EANA DFI FP NTLVG++G QMSGGQKQRIAIARALVRNPKIL+
Sbjct: 63 DVTDEEMERAAREANAYDFIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILI 122
Query: 1589 LDEATSALDAESESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHE 1768
LDEATSALD+ES+S VQ+ALE AS+GRTTIV+AHRLST+R+AD I+ +K G + E G H
Sbjct: 123 LDEATSALDSESKSAVQAALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHA 182
Query: 1769 TLIEQKGLYHELVHAQVFADVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXX 1948
L+ ++GLY+ LV +Q D K E M+ T ++ S+ + +S
Sbjct: 183 ELMAKRGLYYSLVMSQ------DIKKADEQMESMTYSTERKTNSLPLHSVKS-------- 228
Query: 1949 XXXXXXXXXXXXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFS 2128
+ +L KIL+ +PEW + ++ G V P FS
Sbjct: 229 ---IKSDFIDKAEESTQSKEISLPEVSLLKILKLNKPEWPFVVLGTLASVLNGTVHPVFS 285
Query: 2129 LFFSQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRS 2308
+ F++II +F N D+ +K D ++++F++L + S Q +G A E LTMR+R
Sbjct: 286 IIFAKIITMFGNNDKTTLKHDAEIYSMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRH 345
Query: 2309 KVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIA 2488
++ +L QD +FD ++S G +TT LA D I+ A R+G + ++G + I+
Sbjct: 346 LAFKAMLYQDIAWFDEKENSTGGLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIIS 405
Query: 2489 FYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQAL 2668
F YGW+M FL+++I P +AV + G A D +E+++AGK A EA+ENIRT+ +L
Sbjct: 406 FIYGWEMTFLILSIAPVLAVTGMIETAAMTGFANKDKQELKHAGKIATEALENIRTIVSL 465
Query: 2669 TLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVL 2848
T + ++ L H KA I G Y F+++ +F YAA FRFG +LI +
Sbjct: 466 TREKAFEQMYEEMLQTQHRNTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLI--QAGR 523
Query: 2849 MEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYP 3028
M PE + V AI++ IG PEY KA A +F +LE++P ID + G P
Sbjct: 524 MTPEGMFIVFTAIAYGAMAIGKTLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKP 583
Query: 3029 QL-SGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYD 3205
G ++ +V F YP RP V IL+GL++ ++ G+T+A VG SGCGKST + LL+RLYD
Sbjct: 584 DTCEGNLEFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYD 643
Query: 3206 PLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETA 3385
P++G V D D +++N + LR IA+V QEP+LF+ SI ENI YG ++I+ A
Sbjct: 644 PVQGQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEA 703
Query: 3386 CSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDT 3565
+ ANIH FI+ LP+ Y T+VG KG QLSGGQKQR+AIARAL++ PKILLLDEATSALD
Sbjct: 704 ANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDN 763
Query: 3566 ESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYF 3745
+SEK VQ ALD A RTC+VV HRLS I NA I+V+ NG++ EQGTH EL+ R YF
Sbjct: 764 DSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYF 823
Query: 3746 ALTQKQS 3766
L QS
Sbjct: 824 KLVNAQS 830
Score = 371 bits (953), Expect = e-101
Identities = 211/579 (36%), Positives = 329/579 (56%), Gaps = 4/579 (0%)
Frame = +2
Query: 92 LAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHEVIQN 271
+ +G + S G P+ SII F + T+F + + T H+
Sbjct: 267 VVLGTLASVLNGTVHPVFSII-------FAKIITMFGNNDKTT---------LKHDAEIY 310
Query: 272 CLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYDK--NTSGTLS 445
+ +V LG F + F+Q + E L+ R R F +++ Q+IAW+D+ N++G L+
Sbjct: 311 SMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLT 370
Query: 446 NKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFX 625
L ++ +++ TG ++G+ Q ++F Y W +T +++S++P + + G+
Sbjct: 371 TILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGMIE 430
Query: 626 XXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKS 805
+ AG IA E L +IRT+++ ++ + YE+ L+ + KK+
Sbjct: 431 TAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSKKA 490
Query: 806 FLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQF 985
+IG+ A IY +Y F G + +GR+ + VF ++ G+MA+G+
Sbjct: 491 QIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGKTLVLA 550
Query: 986 ATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKG 1165
A AA L+ ++++ P ID+ S EG+ P G + +V F YP R DV IL+G
Sbjct: 551 PEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTCEGNLEFREVSFFYPCRPDVFILRG 610
Query: 1166 VSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGV 1345
+SL + G+TVA VGSSGCGKST +QLLQR Y+P GQ+L D + ++ N+++LR + +
Sbjct: 611 LSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQIAI 670
Query: 1346 VSQEPNLFNTSIEQNIRYGRSD--VSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQ 1519
V QEP LFN SI +NI YG + V ++I A AN FI+ PE NT VG +G Q
Sbjct: 671 VPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLKGAQ 730
Query: 1520 MSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLS 1699
+SGGQKQR+AIARAL++ PKILLLDEATSALD +SE +VQ AL+ A GRT +V+ HRLS
Sbjct: 731 LSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVVTHRLS 790
Query: 1700 TVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQ 1816
++NAD I+V+ G++ E GTH+ L+ + +Y +LV+AQ
Sbjct: 791 AIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNAQ 829
>gi|7494131|pir||T30804 P-glycoprotein 6 - Entamoeba histolytica
gi|405076|gb|AAA21449.1| P-glycoprotein 6
Length = 1282
Score = 698 bits (1802), Expect = 0.0
Identities = 426/1281 (33%), Positives = 675/1281 (52%), Gaps = 39/1281 (3%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+SIF +++Y + ++ + +G+++S GV PL++I++G+V +
Sbjct: 40 VSIFMMFKYATWIEIIFNIIGVLISLCDGVLYPLIAILIGDVFDS------------KAF 87
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
+ A AE + + K++Y+G G+F ++ F + R RR + S++
Sbjct: 88 NPLAYDVAEIENLCNKTSSKFMYIGIGLFFTSLIRTIIFDITGGNQIRRIRRLYIKSLLD 147
Query: 401 QEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLI 580
QE+ WYD + SG ++ ++ ++ + + G KVG F I G+ + F +W L +
Sbjct: 148 QEMGWYDAHNSGEMTFRMSGDIFLLHDAIGQKVGEFFSYFGMCITGYVIGFVKEWKLCFV 207
Query: 581 MMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRY 760
M+S++PFM+ Y+VAGGIA E ++++RTV A ++ ++Y
Sbjct: 208 MISVAPFMVGAAGIFAYVQTRTASSTQASYSVAGGIASETISNMRTVAALGIEKSRIRQY 267
Query: 761 EDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFS 940
L H GI+ S G F ++ ++ + + G + + + + V FS
Sbjct: 268 LQTLRHSLHVGIRASHETGGSTGLLFFFVFCAFWIGYIYGAKKIQKRDMSASKLAIVVFS 327
Query: 941 VMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKV 1120
V+ G++ L Q +I +A +++ I+R P+I + K G I V
Sbjct: 328 VLCGTLGLSQIATPIGSIFKGTSSAYRIFKTIERTPKIKNEGKRHISEIK-EGNIVFEGV 386
Query: 1121 EFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIP 1300
F YPTR D+ IL +L+ + G +V LVG+SGCGKSTII LLQR Y P G+I+ID I
Sbjct: 387 SFCYPTRPDMLILNNFNLEIKAGHSVGLVGASGCGKSTIIGLLQRLYEPVDGKIMIDGID 446
Query: 1301 IEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRS---------DVSD----------- 1420
I +F++ R + GVV QEP+LF SI++NI G D SD
Sbjct: 447 IREFDLYEYRSMFGVVGQEPSLFAISIKENIALGAHRSILAPHYHDTSDPQDCLLMPELE 506
Query: 1421 EDIARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEA 1600
E I + ANA +FI + P+ +T++G RG Q+SGGQKQRI+IARAL+ +PK+L+LDEA
Sbjct: 507 EKIMKCAHIANATNFINSLPQKFDTVLGQRGAQISGGQKQRISIARALMNDPKLLILDEA 566
Query: 1601 TSALDAESESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIE 1780
TSALD +SE IVQ AL+ A+ GRT+++IAHRLST+R+A +I+V GQV+E G + TL+E
Sbjct: 567 TSALDFKSEKIVQRALDKAAAGRTSVIIAHRLSTIRDAHRILVFDHGQVVEDGNYTTLME 626
Query: 1781 QKGLYHELVHAQVFADVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXX 1960
++GL+++LV Q KK+ E+ + + + + +++VD
Sbjct: 627 KQGLFYKLVKNQEMG-------KKQQEKFDNDEDLEE----DVVPDQTEVDKTYIEVDDD 675
Query: 1961 XXXXXXXXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFS 2140
++ R E + +I GA+ P F+ F +
Sbjct: 676 HRTNWQKFSAHFLVFG---------RVFRLNLKEIPWMILGFIGSMIYGALFPIFAYFLA 726
Query: 2141 QIINVFSNPDRDQMKKDGHF--WALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKV 2314
+ I + M D + +FL ++ S + F ++ E LT R+R
Sbjct: 727 EAICMLVTVYLTGMSDDSEIMKYFYIFLGISGAMFISTYLHKAFFMMSGEFLTYRVRKLS 786
Query: 2315 YRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFY 2494
+ + RQD +FD ++S GR+ RLA DA + +G++ + S+ GL + +
Sbjct: 787 FYAICRQDIGWFDKKENSTGRLAGRLAADATKLNGVTGNLIGTMIHCSFSLIIGLVLGYI 846
Query: 2495 YGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTL 2674
+++++ P + + ++ G A + K NA E +ENI+T++ L
Sbjct: 847 TNVKISWVSTIFVPLIVFNTYIQLRISVGFAGPETKIYANAENLMTEVVENIKTIKMLAK 906
Query: 2675 QTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLME 2854
+ +CS+L P AII GL G+ ++ F+ Y+ L + + + +
Sbjct: 907 EDYFKEKYCSYLVKPAKRAPFTAIINGLVLGWVHAFIFWKYSV-----LMYVAGQELKKD 961
Query: 2855 PE---NVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTY 3025
P ++++ L +I F ++GFAA+Y ++ A AA IF +++ + D + G
Sbjct: 962 PSGMPDIMKALCSIIFGAMSVGFAATYMADFGNAKVAAESIFKIIDRKSPQDPFSEEGEK 1021
Query: 3026 PQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYD 3205
+V+L+ + FRYP RP IL G + + G+++ALVGPSGCGKSTVI L+ER Y
Sbjct: 1022 NFTIDQVELDNIKFRYPTRPEQVILDGASFVIPKGKSVALVGPSGCGKSTVIQLIERFYK 1081
Query: 3206 PLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIE-- 3379
P +G V ++ ++++ N LR I V QEP+LF +I ENIV G+ G +T +Q+E
Sbjct: 1082 PEKGTVKINGRNIQEFNLATLRNKIGYVGQEPLLFAGTIGENIVSGM-CGSWTDDQLENG 1140
Query: 3380 ------------TACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNP 3523
A AN H FI +LP GY T +GE+GT LSGGQKQRIAIARALI P
Sbjct: 1141 GNLVAENMDKIVAAAKMANCHNFICQLPQGYNTIIGERGTSLSGGQKQRIAIARALITQP 1200
Query: 3524 KILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQ 3703
++L+LDEATSALD+ESE VQ A+D AK T IV+AHRLST+ ++ I+V+ G+VVEQ
Sbjct: 1201 ELLILDEATSALDSESEMIVQQAIDKIAKQVTSIVIAHRLSTVKDSDIIVVLSGGKVVEQ 1260
Query: 3704 GTHNELIAKRGAYFALTQKQS 3766
GTH+EL+ + G YF L Q Q+
Sbjct: 1261 GTHDELMKEEGVYFHLVQIQA 1281
Score = 276 bits (707), Expect = 2e-72
Identities = 196/622 (31%), Positives = 306/622 (48%), Gaps = 28/622 (4%)
Frame = +2
Query: 2027 NLFKILRYAR-PEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFS-NP---DRDQMKKD 2191
++F + +YA E I+ L G + P ++ + + + NP D +++
Sbjct: 41 SIFMMFKYATWIEIIFNIIGVLISLCDGVLYPLIAILIGDVFDSKAFNPLAYDVAEIENL 100
Query: 2192 GHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSP 2371
+ + F+ + + L + +F + RIR +++L Q+ ++D H+
Sbjct: 101 CNKTSSKFMYIGIGLFFTSLIRTIIFDITGGNQIRRIRRLYIKSLLDQEMGWYDA--HNS 158
Query: 2372 GRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVG 2551
G +T R++ D + AI ++G F+ G I F W++ F+++++ PFM
Sbjct: 159 GEMTFRMSGDIFLLHDAIGQKVGEFFSYFGMCITGYVIGFVKEWKLCFVMISVAPFMVGA 218
Query: 2552 QALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGN 2731
+ +A+S AG A E I N+RTV AL ++ + L +
Sbjct: 219 AGIFAYVQTRTASSTQASYSVAGGIASETISNMRTVAALGIEKSRIRQYLQTLRH----S 274
Query: 2732 ISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSF--GT 2905
+ I G + + FF AF G I+ + + + L + FS GT
Sbjct: 275 LHVGIRASHETGGSTGLLFFFVFCAFWIGY--IYGAKKIQKRDMSASKLAIVVFSVLCGT 332
Query: 2906 IGFAASYFP--EYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVFFRYPE 3079
+G + P K T +A IF +E P+I G + V F YP
Sbjct: 333 LGLSQIATPIGSIFKGTSSAYRIFKTIERTPKIKNEGKRHISEIKEGNIVFEGVSFCYPT 392
Query: 3080 RPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNP 3259
RP + IL N+ +K G ++ LVG SGCGKST+I LL+RLY+P++G + +D D+R+ +
Sbjct: 393 RPDMLILNNFNLEIKAGHSVGLVGASGCGKSTIIGLLQRLYEPVDGKIMIDGIDIREFDL 452
Query: 3260 KHLRKHIALVSQEPILFDTSIRENIVYG-----LQPGEYT-------------HEQIETA 3385
R +V QEP LF SI+ENI G L P + E+I
Sbjct: 453 YEYRSMFGVVGQEPSLFAISIKENIALGAHRSILAPHYHDTSDPQDCLLMPELEEKIMKC 512
Query: 3386 CSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDT 3565
AN FI+ LP ++T +G++G Q+SGGQKQRI+IARAL+ +PK+L+LDEATSALD
Sbjct: 513 AHIANATNFINSLPQKFDTVLGQRGAQISGGQKQRISIARALMNDPKLLILDEATSALDF 572
Query: 3566 ESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYF 3745
+SEK VQ ALD AA RT +++AHRLSTI +A I+V +GQVVE G + L+ K+G ++
Sbjct: 573 KSEKIVQRALDKAAAGRTSVIIAHRLSTIRDAHRILVFDHGQVVEDGNYTTLMEKQGLFY 632
Query: 3746 ALTQKQS-SNQSGGAFDTSEAL 3808
L + Q + FD E L
Sbjct: 633 KLVKNQEMGKKQQEKFDNDEDL 654
>gi|24960750|gb|AAN65444.1| Hypothetical protein [Oryza sativa
(japonica cultivar-group)]
Length = 1482
Score = 697 bits (1800), Expect = 0.0
Identities = 440/1308 (33%), Positives = 665/1308 (50%), Gaps = 62/1308 (4%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+ + L++Y++ +D ++L +G + + G LP S + GN V +
Sbjct: 210 VGVAGLFKYSTAMDIVLLVLGCVGAMINGGSLPWYSYLFGNFVNKIVNVD---------- 259
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
+ + +V Q + +L + +L+ +C+ +I E+ + R RR++ +V+R
Sbjct: 260 ------KTQMMKDVKQISVYMAFLAAVVVVGAYLEITCWRIIGERSALRMRREYLKAVLR 313
Query: 401 QEIAWYDKNTS-GTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
QEI ++D S G + + + ++ +++E G+K+ + F+ G+ V F W + L
Sbjct: 314 QEIGFFDTEVSTGEVMHSISGDVAQIQEVMGEKIPGFVHHVFTFVFGYVVGFAKSWRIAL 373
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
+ +++P MM CG+ Y AG +A++ ++SIRTV++F +E
Sbjct: 374 AVFAVTPAMMACGMAYKAIYGGLTAKEEASYQRAGDVAQQAISSIRTVMSFVMEERLAGE 433
Query: 758 YEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFF 937
Y + L+ G+K F GAG+ +++ Y+ + LA W G+ V +G ++ G + FF
Sbjct: 434 YAEWLDKAAPIGVKMGFAKGAGMGVIYLVTYSQWALALWYGSRLVANGEIKGGDAIACFF 493
Query: 938 SVMMGSMALGQAGQ------------QFATIGTALG------------AAASLYEVIDRI 1045
VM+G Q + +F G AL AA ++EVIDR+
Sbjct: 494 GVMVGGRHAHQPPRTASCCRQWRRSPEFRGWGLALTLSYMAQFAQGTVAAGRVFEVIDRV 553
Query: 1046 PEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCG 1225
PEIDAY G+ + GR+ VEF YP+R D +L ++L +T+ALVG SG G
Sbjct: 554 PEIDAYGAGGRALPAVKGRMEFKDVEFAYPSRPDAMVLYNLNLVIPAAKTLALVGVSGGG 613
Query: 1226 KSTIIQLLQRFYNPD--------------------------------AGQILIDDIPIED 1309
KST+ L++RFY+P AG I +D +
Sbjct: 614 KSTMFALIERFYDPTRGEREWPLTRTQSTTMARSSVIDDEAFASVGCAGSITLDGHDLAS 673
Query: 1310 FNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEGL 1489
N+++LR +G+V QEP LF+TSI +N+ G+ + + D A AN F+ P+G
Sbjct: 674 LNLRWLRSQIGLVGQEPVLFSTSIIENVMMGKENATRHDAISACAMANVHTFVLALPDGY 733
Query: 1490 NTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGR 1669
+T VGDRG Q+SGGQKQRIA+ARA++R+P+ILLLDE TSALD +SE++VQ +++ + GR
Sbjct: 734 DTQVGDRGAQLSGGQKQRIALARAIIRDPRILLLDEPTSALDTQSEAVVQQSIDRLAAGR 793
Query: 1670 TTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVDDKPKK 1849
T +VIAHRL+TVRNAD I V+ G V+E G H L+ ++G Y LV D +
Sbjct: 794 TVVVIAHRLATVRNADTIAVLDRGAVVESGRHADLMARRGPYSALVSLAS----DSGGAR 849
Query: 1850 KEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXGAVKAN 2029
+ + TS T ES D K
Sbjct: 850 PDLAGAAAAYTSF--------TDESGYDVSVSKSRYGFQTIREEEEKKDSQDA----KVR 897
Query: 2030 LFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHFWAL 2209
+ +I R R E + GAV F L Q + V+ + D +MK+ + A+
Sbjct: 898 VSEIWRLQRREGPLLILGFLMGIHAGAVFSVFPLLLGQAVEVYFDADTARMKRQVEYLAM 957
Query: 2210 MFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTR 2389
+ L +M Q L G A RLTMR+R +++R ++RQ+ +FD ++ G + TR
Sbjct: 958 AVVGLGVACILTMTGQQGLCGWAGARLTMRVRDRLFRAIMRQEPAWFDEEDNAMGVLVTR 1017
Query: 2390 LATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMK 2569
LA DA +S R + A+ S G GLGI F W++ + A P + +G + +
Sbjct: 1018 LARDAVAFRSMFGDRYAVLLMAVGSAGVGLGICFGLDWRLTLVATACTP-LTLGASYLNL 1076
Query: 2570 YHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAII 2749
A SD A A A+ N+RTV AL Q + F LD P ++ +
Sbjct: 1077 LINVGARSDDGAYARASGIAAGAVSNVRTVAALCAQGSVVGTFNRALDGPAAKASRRSQL 1136
Query: 2750 RGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYF 2929
G+ G + + Y A G I N + +V ++ + S ++G A
Sbjct: 1137 MGVILGLSQGAMYGAYTATLCAGAHFI--NNGVSTFGDVSKIFLILVLSSFSVGQLAGLA 1194
Query: 2930 PEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSG---EVKLNKVFFRYPERPAVPIL 3100
P+ A A I +L+ P I G ++ G +V+L KV F YP RP V +L
Sbjct: 1195 PDTSGAPAAIAGILTILKRRPAITGDSTKRRITIKDGKPIDVELRKVTFAYPSRPEVTVL 1254
Query: 3101 QGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHI 3280
G ++ VK G T+A+VG SG GKSTV+ L++R YDP +G V V D R+++ K LR
Sbjct: 1255 SGFSLRVKAGTTVAVVGASGSGKSTVVWLVQRFYDPGDGKVVVGGVDARELDLKWLRGEC 1314
Query: 3281 ALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKG 3460
A+V QEP LF SIR+NI +G + +IE A +ANIHKFI LP GYET+VGE G
Sbjct: 1315 AMVGQEPALFSGSIRDNIGFGNPKASWA--EIEEAAKEANIHKFISALPQGYETQVGESG 1372
Query: 3461 TQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHR 3640
QLSGGQKQRIAIARA+++ +ILLLDEA+SALD ESE+ VQ AL A++ T I VAHR
Sbjct: 1373 VQLSGGQKQRIAIARAIVKQARILLLDEASSALDLESERHVQEALRRASRRATAITVAHR 1432
Query: 3641 LSTIVNAGCIMVVKNGQVVEQGTHNELIAKR--GAYFALTQKQSSNQS 3778
LST+ +A I VV G+VVE G H+ L+A G Y A+ + ++ Q+
Sbjct: 1433 LSTVRDADRIAVVSAGRVVEFGGHDALLAGHGDGLYAAMVKAETEAQA 1480
Score = 329 bits (843), Expect = 4e-88
Identities = 208/622 (33%), Positives = 315/622 (50%), Gaps = 58/622 (9%)
Frame = +2
Query: 2096 LIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGV 2275
+I G +P +S F +N N D+ QM KD ++ LAAV + + + +
Sbjct: 235 MINGGSLPWYSYLFGNFVNKIVNVDKTQMMKDVKQISVYMAFLAAVVVVGAYLEITCWRI 294
Query: 2276 AAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNA 2455
ER +R+R + + VLRQ+ +FD + S G + ++ D I+ + ++ +
Sbjct: 295 IGERSALRMRREYLKAVLRQEIGFFDT-EVSTGEVMHSISGDVAQIQEVMGEKIPGFVHH 353
Query: 2456 IASVGGGLGIAFYYGWQMAFLVMAIFP-FMAVGQALMMKYHGGSATSDAKEMENAGKTAM 2632
+ + G + F W++A V A+ P MA G A Y G +A +A + AG A
Sbjct: 354 VFTFVFGYVVGFAKSWRIALAVFAVTPAMMACGMAYKAIYGGLTAKEEAS-YQRAGDVAQ 412
Query: 2633 EAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFR 2812
+AI +IRTV + ++ +L + LD + +G G + + +A A
Sbjct: 413 QAISSIRTVMSFVMEERLAGEYAEWLDKAAPIGVKMGFAKGAGMGVIYLVTYSQWALALW 472
Query: 2813 FGLFLIFDKNVLMEPENVLRVLFAI------------------------SFSFGTIGFAA 2920
+G L+ + + + + + F + F +
Sbjct: 473 YGSRLVANGEI--KGGDAIACFFGVMVGGRHAHQPPRTASCCRQWRRSPEFRGWGLALTL 530
Query: 2921 SYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSG-TYPQLSGEVKLNKVFFRYPERPAVPI 3097
SY ++ + T AAG +F +++ P ID + G P + G ++ V F YP RP +
Sbjct: 531 SYMAQFAQGTVAAGRVFEVIDRVPEIDAYGAGGRALPAVKGRMEFKDVEFAYPSRPDAMV 590
Query: 3098 LQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEG-------------------- 3217
L LN+ + +TLALVG SG GKST+ +L+ER YDP G
Sbjct: 591 LYNLNLVIPAAKTLALVGVSGGGKSTMFALIERFYDPTRGEREWPLTRTQSTTMARSSVI 650
Query: 3218 ------------AVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEY 3361
++T+D +DL +N + LR I LV QEP+LF TSI EN++ G +
Sbjct: 651 DDEAFASVGCAGSITLDGHDLASLNLRWLRSQIGLVGQEPVLFSTSIIENVMMGKENA-- 708
Query: 3362 THEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLD 3541
T +AC+ AN+H F+ LPDGY+T+VG++G QLSGGQKQRIA+ARA+IR+P+ILLLD
Sbjct: 709 TRHDAISACAMANVHTFVLALPDGYDTQVGDRGAQLSGGQKQRIALARAIIRDPRILLLD 768
Query: 3542 EATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNEL 3721
E TSALDT+SE VQ ++D A RT +V+AHRL+T+ NA I V+ G VVE G H +L
Sbjct: 769 EPTSALDTQSEAVVQQSIDRLAAGRTVVVIAHRLATVRNADTIAVLDRGAVVESGRHADL 828
Query: 3722 IAKRGAYFALTQKQSSNQSGGA 3787
+A+RG Y AL S SGGA
Sbjct: 829 MARRGPYSALVSLAS--DSGGA 848
>gi|49092568|ref|XP_407745.1| hypothetical protein AN3608.2
[Aspergillus nidulans FGSC A4]
gi|40740626|gb|EAA59816.1| hypothetical protein AN3608.2 [Aspergillus
nidulans FGSC A4]
Length = 1266
Score = 697 bits (1799), Expect = 0.0
Identities = 440/1267 (34%), Positives = 663/1267 (51%), Gaps = 29/1267 (2%)
Frame = +2
Query: 50 FQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEK 229
F+++ Y+S D ++ G+ + A G LPLM+++ G + NF G L P+
Sbjct: 30 FRVWGYSSVQDHVIRVTGLFAAIACGAALPLMTLVFGTLIDNFNDWGAGKLSPD------ 83
Query: 230 AAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEI 409
EF V QN L + YL IF +C + + R F S++RQ++
Sbjct: 84 -----EFRSHVSQNALWFTYLFISIFVLSSFNTACLRLTATRCVRALRHDFIRSILRQDL 138
Query: 410 AWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMS 589
+++D GT++ L +N + V G G+K+G+A + +AQ F VAF W LTL++ +
Sbjct: 139 SYFDNCLPGTVATVLSNNADLVEIGLGEKLGIAIEGVAQLCAAFVVAFARQWKLTLVVAA 198
Query: 590 LSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDA 769
P M+ + Y+ AGGIAEE L S V A+N RY+
Sbjct: 199 TLPLAMLVIVVTVILETRITTKILAIYSKAGGIAEEALASTHIVKAYNAASKLQARYDSY 258
Query: 770 LEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVL-TVFFSVM 946
LE + G+K+ + G + F I++ +Y LA++ G + G +ESG L TV SV+
Sbjct: 259 LERATQLGVKRGPIRGIQYGAQFAIMFCAYALAWFYGIRLLVKGEIESGGYLITVLTSVL 318
Query: 947 MGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEF 1126
+GS +L G + AA L++VIDR P ID+ S++G+T + ++G IS V F
Sbjct: 319 IGSQSLTLIGPFIGEVSKTAAAAQELFQVIDRKPNIDSLSSDGRTLTGVTGHISFRNVSF 378
Query: 1127 TYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIE 1306
YP+R V++L V++D + G+T A+VGSSG GKSTI+ L+ RF++P +G +L+D PI
Sbjct: 379 AYPSRPSVRVLDDVTVDFEAGKTTAIVGSSGSGKSTILALVSRFFDPVSGSVLLDGHPIH 438
Query: 1307 DFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYG--RSDVS-------DEDIARALKEANAA 1459
+ NI++LR +G V QEP LF+ SI N+ +G R+D+ + A + A A
Sbjct: 439 ELNIRWLRGQIGSVQQEPVLFSESIFANVCHGFFRTDMDLLPEHERRIRVQEACEAAFAH 498
Query: 1460 DFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQ 1639
FI+ PE +T VG +SGGQKQRIAIAR+++RNP ILLLDEATSALD +E VQ
Sbjct: 499 HFIQGLPEQYDTPVGAGDGLLSGGQKQRIAIARSIIRNPPILLLDEATSALDPNAEGTVQ 558
Query: 1640 SALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQ- 1816
+AL N S+ RTTI++AHRLSTV+ AD I+V++ G+V+E G+H L+ +KG Y +LV AQ
Sbjct: 559 AALNNVSKTRTTIIVAHRLSTVQRADNIVVLRKGRVVEQGSHRELLAKKGTYFDLVAAQT 618
Query: 1817 ---VFADVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXX 1987
+ + D+ EA+ + ++ + + +Q S+
Sbjct: 619 EDGIISTAGDQTGTSEADSVLVKKAAVEDYNSAMSSQSSKATAHEKRV------------ 666
Query: 1988 XXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNP 2167
+ LF +LR W + G+V P ++ FS+ I +F P
Sbjct: 667 ---------PLLKCLFILLRGRLQLWPLFFCGLIVSIGAGSVFPVQAVVFSRAILIFQFP 717
Query: 2168 ---DRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQD 2338
+M G+FW ++++VLA F VAA L+ RS+ + +L QD
Sbjct: 718 LPAMASEMLHKGNFWGIIYIVLAVSVLICYAGLGFFFTVAASFLSGTYRSRYFAAMLNQD 777
Query: 2339 ATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFL 2518
++F+ S G +T +L+TD I+ I LG I + +V +A GW++A +
Sbjct: 778 VSFFEEEDQSAGVMTGQLSTDPQRIEDLISLCLGFILLVVVNVLASCILALAVGWRLALV 837
Query: 2519 -VMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNI 2695
+ P + + + ++ + + + A EAI IRTV +LTL+ K+ +
Sbjct: 838 AIFGCLPPLFLAGYVRVRLEITCQERTTRLYLESARFATEAISAIRTVASLTLEEKVIQM 897
Query: 2696 FCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRV 2875
+ L I ++ + G S+ T F +G+ L+ E V
Sbjct: 898 YDERLSHTSPKFIRITLVSAILLGLCESLYLATLGLIFWYGVKLLSQGE--YNVETFFMV 955
Query: 2876 LFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGE--VK 3049
A+ F GF Y KA AA I ++L P I+ T QL + ++
Sbjct: 956 FVAVIFGGQAAGFLLGYTVNTAKAHTAANNIIHILGSRPSINASTGKQETVQLDSDTAIE 1015
Query: 3050 LNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTV 3229
V F YP RP VP+LQGL+ VK G+ + LVG SGCGK+TVISLLER Y+ G + +
Sbjct: 1016 FKDVHFSYPARPTVPVLQGLSFKVKKGEHIGLVGASGCGKTTVISLLERFYEAGSGEIFI 1075
Query: 3230 DNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHE---QIETACSK-- 3394
+ L ++ R I LV+Q P L+ SIR+N++ G+ E QIE +K
Sbjct: 1076 NGIPLHDIDVHSHRARIGLVTQNPTLYQGSIRDNVLIGISISHQNEELDSQIEEKLTKAY 1135
Query: 3395 --ANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTE 3568
ANI FI LP+G +T G +G LSGGQ+QRIAIARALIR+P++LL DEATSALDTE
Sbjct: 1136 KDANIQDFIQSLPEGQQTDPGTRGLALSGGQRQRIAIARALIRDPELLLFDEATSALDTE 1195
Query: 3569 SEKQVQVALDAAA--KDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAY 3742
+E+ VQ A++ + RT I VAHRL+T+ I+V+ G+V E+GTH EL+A+ G Y
Sbjct: 1196 NERLVQEAIERVSHGPGRTTISVAHRLTTVRRCDRILVLHEGRVEEEGTHAELMARGGRY 1255
Query: 3743 FALTQKQ 3763
+ + Q
Sbjct: 1256 YQMVLAQ 1262
Score = 321 bits (823), Expect = 7e-86
Identities = 200/588 (34%), Positives = 314/588 (53%), Gaps = 21/588 (3%)
Frame = +2
Query: 2105 GAVMPAFSLFFSQIINVFSN-------PD--RDQMKKDGHFWALMFLVLAAVQGTSMLFQ 2257
GA +P +L F +I+ F++ PD R + ++ ++ +F+ + + F
Sbjct: 55 GAALPLMTLVFGTLIDNFNDWGAGKLSPDEFRSHVSQNALWFTYLFISIFVLSS----FN 110
Query: 2258 CSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRL 2437
+ + A R +R R++LRQD +YFD PG + T L+ +A ++ + +L
Sbjct: 111 TACLRLTATRCVRALRHDFIRSILRQDLSYFD--NCLPGTVATVLSNNADLVEIGLGEKL 168
Query: 2438 GSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENA 2617
G +A + +AF W++ +V A P + + + T A
Sbjct: 169 GIAIEGVAQLCAAFVVAFARQWKLTLVVAATLPLAMLVIVVTVILETRITTKILAIYSKA 228
Query: 2618 GKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTY 2797
G A EA+ + V+A +KL + S+L+ + + IRG+ YG +I F Y
Sbjct: 229 GGIAEEALASTHIVKAYNAASKLQARYDSYLERATQLGVKRGPIRGIQYGAQFAIMFCAY 288
Query: 2798 AAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNM 2977
A A+ +G+ L+ K + ++ VL ++ ++ + E K AA +F +
Sbjct: 289 ALAWFYGIRLLV-KGEIESGGYLITVLTSVLIGSQSLTLIGPFIGEVSKTAAAAQELFQV 347
Query: 2978 LEEEPRIDGMTSSG-TYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGP 3154
++ +P ID ++S G T ++G + V F YP RP+V +L + V + G+T A+VG
Sbjct: 348 IDRKPNIDSLSSDGRTLTGVTGHISFRNVSFAYPSRPSVRVLDDVTVDFEAGKTTAIVGS 407
Query: 3155 SGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENI 3334
SG GKST+++L+ R +DP+ G+V +D + + ++N + LR I V QEP+LF SI N+
Sbjct: 408 SGSGKSTILALVSRFFDPVSGSVLLDGHPIHELNIRWLRGQIGSVQQEPVLFSESIFANV 467
Query: 3335 VYG-------LQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRI 3493
+G L P +++ AC A H FI LP+ Y+T VG LSGGQKQRI
Sbjct: 468 CHGFFRTDMDLLPEHERRIRVQEACEAAFAHHFIQGLPEQYDTPVGAGDGLLSGGQKQRI 527
Query: 3494 AIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIM 3673
AIAR++IRNP ILLLDEATSALD +E VQ AL+ +K RT I+VAHRLST+ A I+
Sbjct: 528 AIARSIIRNPPILLLDEATSALDPNAEGTVQAALNNVSKTRTTIIVAHRLSTVQRADNIV 587
Query: 3674 VVKNGQVVEQGTHNELIAKRGAYFALTQKQSS----NQSGGAFDTSEA 3805
V++ G+VVEQG+H EL+AK+G YF L Q+ + +G TSEA
Sbjct: 588 VLRKGRVVEQGSHRELLAKKGTYFDLVAAQTEDGIISTAGDQTGTSEA 635
>gi|27368867|emb|CAD59591.1| MDR-like ABC transporter [Oryza sativa
(japonica cultivar-group)]
Length = 1255
Score = 694 bits (1792), Expect = 0.0
Identities = 428/1273 (33%), Positives = 668/1273 (51%), Gaps = 33/1273 (2%)
Frame = +2
Query: 44 SIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTAS 223
S +L RY DR ++A+G++ S G+ PL +++G++ ++ G A
Sbjct: 8 SFLRLVRYADAHDRCLMALGVLGSFGDGMMQPLSMLVLGDIVNSYGGAGG--------AG 59
Query: 224 EKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQ 403
+AR+ FS + L C+ E+ ++R RR + +V+ Q
Sbjct: 60 GAGSARSAFSSGAVDKGL------------------CWTRTAERQASRMRRLYLEAVLSQ 101
Query: 404 EIAWYDKNTSGTLS-------------NKLFDNLERVREGTGDKVGLAFQMMAQFIGGFA 544
E+A++D S S + + D+ + +++ G+K+ + F G A
Sbjct: 102 EVAFFDAAPSSPSSPQAQAQATTFRVISTVSDDADAIQDFLGEKLPMVLANATLFFGALA 161
Query: 545 VAFTYDWLLTL------IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLT 706
V+F + W L L +++ ++P +++ G Y AGGIA++ ++
Sbjct: 162 VSFVFAWRLALAGLPFTLLLFVTPSVLLAGRMAAAAGEARVA-----YEEAGGIAQQAVS 216
Query: 707 SIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTN 886
SIRTV ++ + +R+ A+ G+++ + GA + S VI YA + W+G+
Sbjct: 217 SIRTVASYTAERRTVERFRGAVARSAALGVRQGLIKGAVIGSMGVI-YAVWSFLSWIGSL 275
Query: 887 FVYSGRLESGTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYS 1066
V + G V +++ M++ A A AA+ + E+I+ +P ++
Sbjct: 276 LVIHLHAQGGHVFVASICIVLAGMSIMMALPNLRYFIDATAAASRMQEMIEMLPPLEGAE 335
Query: 1067 TEGQTPSKISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQL 1246
+G T +I G I V F+YP+R D +L G +L G TV LVG SG GKST+I L
Sbjct: 336 KKGATMERIRGEIVFKDVHFSYPSRPDTLVLNGFNLTISEGATVGLVGGSGSGKSTVISL 395
Query: 1247 LQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDED 1426
LQRFY+PD+G+I +DD I+ N+++LR +G+VSQEP LF TSI +NI +G S +
Sbjct: 396 LQRFYSPDSGEISMDDHGIDTLNVEWLRSQIGLVSQEPVLFATSIRENILFGDETASLKQ 455
Query: 1427 IARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATS 1606
+ A K ANA +FI P G T VG G Q+SGGQKQRIAIARALVR+P+ILLLDEATS
Sbjct: 456 VVAAAKMANAHEFIVKLPHGYETHVGQFGTQLSGGQKQRIAIARALVRDPRILLLDEATS 515
Query: 1607 ALDAESESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLI--- 1777
ALDAESE VQ AL+ AS GRTT+++AHRLST+R AD I V+ AG+V+E GTH+ L+
Sbjct: 516 ALDAESERTVQDALDRASVGRTTVIVAHRLSTLRKADTIAVLDAGRVVEAGTHDELLGMD 575
Query: 1778 --EQKGLYHELVHAQVFADVDDKPKKKEA-ERRMSRQTSQRKGSVNFKTQESQVDXXXXX 1948
+ G+Y +VH Q V + ++ A + S S R + ++
Sbjct: 576 DGGEGGVYARMVHLQKAPPVAAREERHRAVDVVESEMVSFRSVEIMSAVSATEHRPSPAP 635
Query: 1949 XXXXXXXXXXXXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFS 2128
+ K + ++L+ RPEW ++ GAV+P +S
Sbjct: 636 SFCSVEHSTEIGRKLVDHGVARSRKPSKLRLLKMNRPEWKQALLGCVGAVVFGAVLPLYS 695
Query: 2129 LFFSQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRS 2308
+ V+ D Q++ ++ +FL +A V T+ + Q F V ERLT R+R
Sbjct: 696 YSLGSLPEVYFLADDGQIRSKTRLYSFLFLGIAVVCITANIVQHYNFAVMGERLTERVRG 755
Query: 2309 KVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIA 2488
++ +L + +FD ++S + RLAT + ++S + R+ + A A+ G +A
Sbjct: 756 QMLAKILSFEVGWFDEDENSSAAVCARLATQSSKVRSLVGDRMCLLVQAGATASLGFSLA 815
Query: 2489 FYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAG-KTAMEAIENIRTVQA 2665
W++A ++MA+ P + + K + + AK+ + G + A EA+ N RT+ A
Sbjct: 816 LAVSWRLATVMMAMQP-LIIASFYFKKVLMAAMSKKAKKAQVQGSQLASEAVVNHRTITA 874
Query: 2666 LTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNV 2845
+ Q ++ ++ + P N++ + G + A A +G L+
Sbjct: 875 FSSQRRMLRLYEAAQQGPKKDNVAHSWFSGFCLCLCQFSNTGSMAVALWYGGKLM--AKG 932
Query: 2846 LMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRI-----DGMT 3010
L+ P ++ +V F + I A S + + A + + L+ EP I D
Sbjct: 933 LITPTHLFQVFFMLMTMGRVIADAGSLTSDLAQGGDAVRSVLDTLDREPTIKDDDNDNER 992
Query: 3011 SSGTYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLL 3190
++ G ++ V F YP RP V +L G ++ + G+T+ALVGPSG GKSTVI L+
Sbjct: 993 KKKKRKEIKGAIEFKNVHFSYPTRPEVAVLSGFSLEIGAGKTVALVGPSGSGKSTVIGLI 1052
Query: 3191 ERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHE 3370
ER YD G+V VD D+R + LR +ALVSQEP LF +IR+NI YG T +
Sbjct: 1053 ERFYDAQRGSVLVDGEDIRSYSLARLRSQVALVSQEPTLFSGTIRDNIAYGAAEEHATED 1112
Query: 3371 QIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEAT 3550
++ A + AN H FI + GY+TRVGE+G QLSGGQ+QRIA+ARA++++ +ILLLDEAT
Sbjct: 1113 EVARAAALANAHGFISAMERGYDTRVGERGAQLSGGQRQRIALARAVLKDARILLLDEAT 1172
Query: 3551 SALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIA- 3727
SALD SE+ VQ A+D + RTC+VVAHRLST+ + I VVK+G+V E+G H+EL+A
Sbjct: 1173 SALDAASERLVQDAVDRMLRGRTCVVVAHRLSTVEKSDTIAVVKDGRVAERGRHHELLAV 1232
Query: 3728 -KRGAYFALTQKQ 3763
+ G Y+ L + Q
Sbjct: 1233 GRAGTYYNLIKLQ 1245
>gi|15232975|ref|NP_189477.1| ABC transporter family protein
[Arabidopsis thaliana]
Length = 1158
Score = 693 bits (1788), Expect = 0.0
Identities = 414/1170 (35%), Positives = 634/1170 (53%), Gaps = 10/1170 (0%)
Frame = +2
Query: 284 VYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYD---KNTSGTLSNKL 454
+Y+ C + FL+ C+ E+ + + R ++ +V+RQ++ ++D +TS +++
Sbjct: 2 LYVACASWVICFLEGYCWTRTGERQAAKMRERYLRAVLRQDVGYFDLHVTSTSDIITSVS 61
Query: 455 FDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXXXX 634
D+L +++ +K+ + F+G + V F W LT++ ++I GL
Sbjct: 62 SDSLV-IQDFLSEKLPNILMNASAFVGSYIVGFMLLWRLTIVGFPFIILLLIPGLMYGRA 120
Query: 635 XXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFLI 814
+Y AG IAE+ ++S+RTV AF ++ +++ DAL+ K G+++
Sbjct: 121 LIGISRKIREEYNEAGSIAEQAISSVRTVYAFVSEKKMIEKFSDALQGSVKLGLRQGLAK 180
Query: 815 GAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQFATI 994
G + S I+YA + W G+ V + + GTV TV V G ALGQA
Sbjct: 181 GIAIGSNG-IVYAIWGFLTWYGSRMVMNYGYKGGTVSTVTVCVTFGGTALGQALSNLKYF 239
Query: 995 GTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKGVSL 1174
A A + ++I R+P+ID+ + G I G + N V+ YP+R + I + L
Sbjct: 240 SEAFVAGERIQKMIKRVPDIDSDNLNGHILETIRGEVEFNNVKCKYPSRPETLIFDDLCL 299
Query: 1175 DAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQ 1354
G+TVALVG SG GKST+I LLQRFY+P+ G ILID + I + +K+LR +G+VSQ
Sbjct: 300 KIPSGKTVALVGGSGSGKSTVISLLQRFYDPNEGDILIDSVSINNMQVKWLRSQMGMVSQ 359
Query: 1355 EPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQ 1534
EP+LF TSI++NI +G+ D S +++ A K +NA +FI FP G T VG+RGV MSGGQ
Sbjct: 360 EPSLFATSIKENILFGKEDASFDEVVEAAKASNAHNFISQFPHGYQTQVGERGVHMSGGQ 419
Query: 1535 KQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLSTVRNA 1714
KQRIAIARAL+++P ILLLDEATSALD ESE +VQ AL+NAS GRTTIVIAHRLST+RNA
Sbjct: 420 KQRIAIARALIKSPIILLLDEATSALDLESERVVQEALDNASVGRTTIVIAHRLSTIRNA 479
Query: 1715 DKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVDDKPKKKEAERRMSRQTSQRK 1894
D I V+ G ++E G+H+ L+E G Y LV Q + K E + ++
Sbjct: 480 DIICVLHNGCIVETGSHDKLMEIDGKYTSLVRLQ---------QMKNEESCDNTSVGVKE 530
Query: 1895 GSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXGAVKANLFKILRYARPEWIYX 2074
G V+ + + +D + + +++ RPEW +
Sbjct: 531 GRVS--SLRNDLDYNPRDLAHSMSSSIVTNLSDSIPQDKKPLVPSFKRLMAMNRPEWKHA 588
Query: 2075 XXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLF 2254
+ GAV P ++ +I+VF + +Q+K++ + L+F LA + +
Sbjct: 589 LCGCLSASLGGAVQPIYAYSSGLMISVFFLTNHEQIKENTRIYVLLFFGLALFTFFTSIS 648
Query: 2255 QCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYR 2434
Q F E LT RIR ++ +L + +FD ++S G I +RLA DA ++S + R
Sbjct: 649 QQYSFSYMGEYLTKRIREQMLSKILTFEVNWFDEEENSSGAICSRLAKDANVVRSLVGER 708
Query: 2435 LGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMEN 2614
+ + I++V I W+ +++++ P + V + + +
Sbjct: 709 MSLLVQTISTVMVACTIGLVIAWRFTIVMISVQPVIIVCYYIQRVLLKNMSKKAIIAQDE 768
Query: 2615 AGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFT 2794
+ K A EA+ NIRT+ + Q ++ + + P + ++ + G+ G S+ T
Sbjct: 769 SSKLAAEAVSNIRTITTFSSQERIMKLLERVQEGPRRESARQSWLAGIMLGTTQSLITCT 828
Query: 2795 YAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFA----ASYFPEYIKATFAAG 2962
A F +G LI D + V + F + F T G A + + K + +
Sbjct: 829 SALNFWYGGKLIADGKM------VSKAFFELFLIFKTTGRAIAEAGTMTTDLAKGSNSVD 882
Query: 2963 LIFNMLEEEPRIDGMTSSG-TYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTL 3139
+F +L+ I+ G ++ G++ V F YP RP + I ++ + G++
Sbjct: 883 SVFTVLDRRTTIEPENPDGYILEKIKGQITFLNVDFAYPTRPNMVIFNNFSIEIHEGKST 942
Query: 3140 ALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTS 3319
A+VGPS GKSTVI L+ER YDPL+G V +D D+R + + LR+H++LVSQEP LF +
Sbjct: 943 AIVGPSRSGKSTVIGLIERFYDPLQGIVKIDGRDIRSYHLRSLRQHMSLVSQEPTLFAGT 1002
Query: 3320 IRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAI 3499
IRENI+YG + +I A AN H+FI L DGY+T G++G QLSGGQKQRIAI
Sbjct: 1003 IRENIMYGRASNKIDESEIIEAGKTANAHEFITSLSDGYDTYCGDRGVQLSGGQKQRIAI 1062
Query: 3500 ARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVV 3679
AR +++NP ILLLDEATSALD++SE+ VQ AL+ +T +V+AHRLSTI N I V+
Sbjct: 1063 ARTILKNPSILLLDEATSALDSQSERVVQDALEHVMVGKTSVVIAHRLSTIQNCDTIAVL 1122
Query: 3680 KNGQVVEQGTHNELIAK--RGAYFALTQKQ 3763
G+VVE GTH L+AK G+YF+L Q
Sbjct: 1123 DKGKVVESGTHASLLAKGPTGSYFSLVSLQ 1152
Score = 310 bits (793), Expect = 2e-82
Identities = 199/517 (38%), Positives = 289/517 (55%), Gaps = 11/517 (2%)
Frame = +2
Query: 2282 ERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIF-NAI 2458
ER ++R + R VLRQD YFD+ S I T +++D+ I+ + +L +I NA
Sbjct: 24 ERQAAKMRERYLRAVLRQDVGYFDLHVTSTSDIITSVSSDSLVIQDFLSEKLPNILMNAS 83
Query: 2459 ASVGGGLGIAFYYGWQMA-----FLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGK 2623
A VG + + F W++ F+++ + P + G+AL+ G + +E AG
Sbjct: 84 AFVGSYI-VGFMLLWRLTIVGFPFIILLLIPGLMYGRALI-----GISRKIREEYNEAGS 137
Query: 2624 TAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAA 2803
A +AI ++RTV A + K+ F L G++ + +GL G A YA
Sbjct: 138 IAEQAISSVRTVYAFVSEKKMIEKFSDALQ----GSVKLGLRQGLAKGIAIGSNGIVYAI 193
Query: 2804 AFRFGLFLIFDKNVLM----EPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIF 2971
+G + ++M + V V ++F +G A S + +A A I
Sbjct: 194 ---WGFLTWYGSRMVMNYGYKGGTVSTVTVCVTFGGTALGQALSNLKYFSEAFVAGERIQ 250
Query: 2972 NMLEEEPRIDGMTSSGTYPQ-LSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALV 3148
M++ P ID +G + + GEV+ N V +YP RP I L + + G+T+ALV
Sbjct: 251 KMIKRVPDIDSDNLNGHILETIRGEVEFNNVKCKYPSRPETLIFDDLCLKIPSGKTVALV 310
Query: 3149 GPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRE 3328
G SG GKSTVISLL+R YDP EG + +D+ + M K LR + +VSQEP LF TSI+E
Sbjct: 311 GGSGSGKSTVISLLQRFYDPNEGDILIDSVSINNMQVKWLRSQMGMVSQEPSLFATSIKE 370
Query: 3329 NIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARA 3508
NI++G + + +++ A +N H FI + P GY+T+VGE+G +SGGQKQRIAIARA
Sbjct: 371 NILFGKEDASF--DEVVEAAKASNAHNFISQFPHGYQTQVGERGVHMSGGQKQRIAIARA 428
Query: 3509 LIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNG 3688
LI++P ILLLDEATSALD ESE+ VQ ALD A+ RT IV+AHRLSTI NA I V+ NG
Sbjct: 429 LIKSPIILLLDEATSALDLESERVVQEALDNASVGRTTIVIAHRLSTIRNADIICVLHNG 488
Query: 3689 QVVEQGTHNELIAKRGAYFALTQKQSSNQSGGAFDTS 3799
+VE G+H++L+ G Y +L + Q +TS
Sbjct: 489 CIVETGSHDKLMEIDGKYTSLVRLQQMKNEESCDNTS 525
>gi|46111809|ref|XP_382962.1| hypothetical protein FG02786.1
[Gibberella zeae PH-1]
gi|42548002|gb|EAA70845.1| hypothetical protein FG02786.1 [Gibberella
zeae PH-1]
Length = 1244
Score = 689 bits (1778), Expect = 0.0
Identities = 425/1253 (33%), Positives = 650/1253 (50%), Gaps = 15/1253 (1%)
Frame = +2
Query: 53 QLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKA 232
+++ Y + ++ V + A G LPLM ++ G F T L P
Sbjct: 61 RVFTYNDQLGWILNGVAFVCMVAAGTILPLMDLVFGKFINVFTDFATGSLSP-------- 112
Query: 233 AARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIA 412
A + EV + L +VYL F ++ + + R F S +RQE++
Sbjct: 113 ---AGYRTEVSKYSLYFVYLFIAKFVLTYIWTILVSIAAINTTKSLRVDFVRSTLRQEVS 169
Query: 413 WYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSL 592
++D S ++ ++ N + +G +K G+ ++ F+ F VAF W LTLI++++
Sbjct: 170 FFDSPAS-SIPGQITTNGNLINQGISEKFGITIAALSTFVSAFIVAFAVQWKLTLIVLAI 228
Query: 593 SPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDAL 772
P ++ + Y+ + +AEE ++IRT AF KR+ L
Sbjct: 229 IPVNLVVTIICVAIDTGYEYAMFDVYSRSSSLAEEAFSTIRTAHAFWAFPKLSKRFTSTL 288
Query: 773 EHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRL-ESGTVLTVFFSVMM 949
E ++ G KKS++ + F I+A Y LAFW G SG + + GTV+TV F++++
Sbjct: 289 EEARRIGHKKSWVYMILFPTEFFCIFAGYGLAFWQGMRMYSSGEITQPGTVVTVIFAILV 348
Query: 950 GSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFT 1129
+ AL Q Q I A AA ++E+IDR +ID S +G+T G I +V F
Sbjct: 349 AATALTQIAPQTIAISKATAAAQEMFEMIDRKSQIDPLSQQGETIPDFKGNIQFREVRFA 408
Query: 1130 YPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIED 1309
YP+R++V IL+ + L+ +T ALVG+SG GKST+ LL+R+Y P +G I +D P+E+
Sbjct: 409 YPSRSNVTILRSLDLNIPADRTTALVGASGSGKSTVFGLLERWYTPSSGSITLDGHPVEN 468
Query: 1310 FNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRS-----DVSDED----IARALKEANAAD 1462
NI++LR + +V QEP LF+ +I QN+ G + D+ +E+ + A K A A D
Sbjct: 469 LNIQWLRTNIRMVQQEPTLFSGTIYQNVVDGLTGTPMVDLPEEEKQRMVIEACKSAYAHD 528
Query: 1463 FIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQS 1642
FI+T P+G +T +G+RG +SGGQKQR+ IAR+++ NPK+L+LDEATSALD +E IVQ
Sbjct: 529 FIETLPKGYDTWIGERGASLSGGQKQRVVIARSIISNPKVLMLDEATSALDPNAEKIVQK 588
Query: 1643 ALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVF 1822
AL N ++GRT IVIAHRLST+R+AD IIVM G+ +E G+H L+E G Y L V
Sbjct: 589 ALNNVAKGRTMIVIAHRLSTIRDADNIIVMAKGETIEQGSHNELLEGGGTYSRL---HVV 645
Query: 1823 ADVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXX 2002
AD+ TQ +
Sbjct: 646 ADI---------------------------TQSDAI------------------------ 654
Query: 2003 XXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQM 2182
G +K L+ ++R RP W ++ GA PA ++ FS+ + F D
Sbjct: 655 -SYGLLK-GLWLVIREQRPLWFSGFILVIISVLGGATYPALAILFSRTMKAFETID---- 708
Query: 2183 KKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPK 2362
+ +F++LMF V+A + + + M RS+++ N LRQD ++FD P
Sbjct: 709 VSEANFFSLMFFVVALANFVIYAVAGWVCNEIGQHVMMVYRSELFDNTLRQDMSFFDDPD 768
Query: 2363 HSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAF-LVMAIFPF 2539
G + +RLA + +++ + L I I +V +A YG+++ L +A P
Sbjct: 769 RGTGALVSRLAAEPTSLQELLSMNLSLIMINIVTVLSSSILAIAYGYKLGLVLTLAALPV 828
Query: 2540 MAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAP 2719
+ + ++ A + A EA+ IRTV +L L+ + + + L
Sbjct: 829 LVGSGYVRIRLEYKFDDDTAGRFAKSSGLASEAVLGIRTVSSLALERAVIERYSNALGGL 888
Query: 2720 HGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSF 2899
I + L Y F+ S F A F +G L+ + V + A+ FS
Sbjct: 889 AKEAIGSLGWKMLFYSFSQSASFLAMALGFWYGGRLVSTGEYTTDQFYV--IFIAVVFSG 946
Query: 2900 GTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGM-TSSGTYPQLSG---EVKLNKVFF 3067
T Y KA A IF + ++ D + G +G ++ +++ F
Sbjct: 947 ETSAMLFQYTTSITKARTAINYIFELRRQKVLHDDVGNGPGGEKNPTGKGIDISCDEITF 1006
Query: 3068 RYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLR 3247
YP RP +P+L+G+++ ++PG+ +ALVG SGCGKST+I+LLER YDP G + ++ D+
Sbjct: 1007 AYPRRPKLPVLRGVDISIEPGKMVALVGASGCGKSTMIALLERFYDPTSGMIKAESQDIS 1066
Query: 3248 QMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELP 3427
+ + R+ IALV QEP+L+ SIR+NI G++ G + +I AC +AN+++FI LP
Sbjct: 1067 TKDRRLHRRDIALVQQEPVLYQGSIRDNISLGIEEGNPSDGEIIEACKQANVYEFISSLP 1126
Query: 3428 DGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAA 3607
+G T G +G LSGGQ+QRIAIARALIR P++LLLDEATSALD ESEK V+ ALD AA
Sbjct: 1127 EGLATSCGNQGLSLSGGQRQRIAIARALIRKPRLLLLDEATSALDAESEKVVKEALDRAA 1186
Query: 3608 KDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQS 3766
+ RT + VAHRLSTI A I V G++VE+G H +L+AKRG Y+ + QS
Sbjct: 1187 EGRTTVAVAHRLSTIREADTICVFSGGKIVERGRHEDLVAKRGLYYEMVLGQS 1239
>gi|4587971|gb|AAD25925.1| ABC transporter protein AtrC [Emericella
nidulans]
Length = 1293
Score = 685 bits (1768), Expect = 0.0
Identities = 437/1267 (34%), Positives = 657/1267 (51%), Gaps = 29/1267 (2%)
Frame = +2
Query: 50 FQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEK 229
F+++ Y+S D ++ G+ + A G LP+M+++ G + NF G L P+
Sbjct: 57 FRVWGYSSVQDHVIRVTGLFAAIACGAALPMMTLVFGTLIDNFNDWGAGKLSPD------ 110
Query: 230 AAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEI 409
EF V QN L + YL IF +C + + R F S++RQ++
Sbjct: 111 -----EFRSHVSQNALWFTYLFISIFVLSSFNTACLRLTATRCVRALRHDFIRSILRQDL 165
Query: 410 AWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMS 589
+++D GT++ L +N + V G G+K+G+A + +AQ F VAF W LTL++ +
Sbjct: 166 SYFDNCLPGTVATVLSNNADLVEIGLGEKLGIAIEGVAQLCAAFVVAFARQWKLTLVVAA 225
Query: 590 LSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDA 769
P M+ + Y+ AGGIAEE L S V A+N RY+
Sbjct: 226 TLPLAMLVIVVTVILETRITTKILAIYSKAGGIAEEALASTHIVKAYNAASKLQARYDSY 285
Query: 770 LEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVL-TVFFSVM 946
LE + G+K+ + G + F I++ +Y LA++ G + G +ESG L TV SV+
Sbjct: 286 LERATQLGVKRGPIRGIQYGAQFAIMFCAYALAWFYGIRLLVKGEIESGGYLITVLTSVL 345
Query: 947 MGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEF 1126
+GS +L G + AA L++VIDR P ID+ S++G+T + ++G IS V F
Sbjct: 346 IGSQSLTLIGPFIGEVSKTAAAAQELFQVIDRKPNIDSLSSDGRTLTGVTGHISFRNVSF 405
Query: 1127 TYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIE 1306
YP+R V++L V++D + G+T A+VGSSG GKSTI+ L+ RF++P +G +L+D PI
Sbjct: 406 AYPSRPSVRVLDDVTVDFEAGKTTAIVGSSGSGKSTILALVSRFFDPVSGSVLLDGHPIH 465
Query: 1307 DFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYG--RSDVS-------DEDIARALKEANAA 1459
+ NI++LR +G V QEP LF+ SI N+ +G R+D+ + A + A A
Sbjct: 466 ELNIRWLRGQIGSVQQEPVLFSESIFANVCHGFFRTDMDLLPEHERRIRVQEACEAAFAH 525
Query: 1460 DFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQ 1639
FI+ PE +T VG +SGGQKQRIAIAR+++RNP ILLLDEATSALD +E VQ
Sbjct: 526 HFIQGLPEQYDTPVGAGDGLLSGGQKQRIAIARSIIRNPPILLLDEATSALDPNAEGTVQ 585
Query: 1640 SALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQ- 1816
+AL N S+ RTTI++AHRLSTV+ AD I+V++ G+V+E G+H L+ +KG Y +LV AQ
Sbjct: 586 AALNNVSKTRTTIIVAHRLSTVQRADNIVVLRKGRVVEQGSHRELLAKKGTYFDLVAAQT 645
Query: 1817 ---VFADVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXX 1987
+ + D+ EA+ + ++ + + +Q S+
Sbjct: 646 EDGIISTAGDQTGTSEADSVLVKKAAVEDYNSAMSSQSSKATAHEKRV------------ 693
Query: 1988 XXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNP 2167
+ LF +LR W +P S F Q +F P
Sbjct: 694 ---------PLLKCLFILLRGRLQLWPLFFCGLIVLYRCRQCLPCSSGRFQQSHLIFQFP 744
Query: 2168 ---DRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQD 2338
+M G+FW ++++VLA F VAA L+ RS+ + +L QD
Sbjct: 745 LPAMASEMLHKGNFWGIIYIVLAVSVLICYAGLGFFFTVAASFLSGTYRSRYFAAMLNQD 804
Query: 2339 ATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFL 2518
++F+ S G +T +L+TD I+ I LG I + +V +A GW++A +
Sbjct: 805 VSFFEEEDQSAGVMTGQLSTDPQRIEDLISLCLGFILLVVVNVLASCILALAVGWRLALV 864
Query: 2519 -VMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNI 2695
+ P + + + ++ + + + A EAI IRTV +LTL+ K+ +
Sbjct: 865 AIFGCLPPLFLAGYVRVRLEITCQERTTRLYLESARFATEAISAIRTVASLTLEEKVIQM 924
Query: 2696 FCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRV 2875
+ L I ++ + G S+ T F +G+ L+ E V
Sbjct: 925 YDERLSHTSPKFIRITLVSAILLGLCESLYLATLGLIFWYGVKLLSQGE--YNVETFFMV 982
Query: 2876 LFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGE--VK 3049
A+ F GF Y KA AA I ++L P I+ T QL + ++
Sbjct: 983 FVAVIFGGQAAGFLLGYTVNTAKAHTAANNIIHILGSRPSINASTGKQETVQLDSDTAIE 1042
Query: 3050 LNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTV 3229
V F YP RP VP+LQGL+ VK G+ + LVG SGCGK+TVISLLER Y+ G + +
Sbjct: 1043 FKDVHFSYPARPTVPVLQGLSFKVKKGEHIGLVGASGCGKTTVISLLERFYEAGSGEIFI 1102
Query: 3230 DNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHE---QIETACSK-- 3394
+ L ++ R I LV+Q P L+ SIR+N++ G+ E QIE +K
Sbjct: 1103 NGIPLHDIDVHSHRARIGLVTQNPTLYQGSIRDNVLIGISISHQNEELDSQIEEKLTKAY 1162
Query: 3395 --ANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTE 3568
ANI FI LP+G +T G +G LSGGQ+QRIAIARALIR+P++LL DEATSALDTE
Sbjct: 1163 KDANIQDFIQSLPEGQQTDPGTRGLALSGGQRQRIAIARALIRDPELLLFDEATSALDTE 1222
Query: 3569 SEKQVQVALDAAA--KDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAY 3742
+E+ VQ A++ + RT I VAHRL+T+ I+V+ G+V E+GTH EL+A+ G Y
Sbjct: 1223 NERLVQEAIERVSHGPGRTTISVAHRLTTVRRCDRILVLHEGRVEEEGTHAELMARGGRY 1282
Query: 3743 FALTQKQ 3763
+ + Q
Sbjct: 1283 YQMVLAQ 1289
Score = 321 bits (823), Expect = 7e-86
Identities = 200/588 (34%), Positives = 314/588 (53%), Gaps = 21/588 (3%)
Frame = +2
Query: 2105 GAVMPAFSLFFSQIINVFSN-------PD--RDQMKKDGHFWALMFLVLAAVQGTSMLFQ 2257
GA +P +L F +I+ F++ PD R + ++ ++ +F+ + + F
Sbjct: 82 GAALPMMTLVFGTLIDNFNDWGAGKLSPDEFRSHVSQNALWFTYLFISIFVLSS----FN 137
Query: 2258 CSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRL 2437
+ + A R +R R++LRQD +YFD PG + T L+ +A ++ + +L
Sbjct: 138 TACLRLTATRCVRALRHDFIRSILRQDLSYFD--NCLPGTVATVLSNNADLVEIGLGEKL 195
Query: 2438 GSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENA 2617
G +A + +AF W++ +V A P + + + T A
Sbjct: 196 GIAIEGVAQLCAAFVVAFARQWKLTLVVAATLPLAMLVIVVTVILETRITTKILAIYSKA 255
Query: 2618 GKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTY 2797
G A EA+ + V+A +KL + S+L+ + + IRG+ YG +I F Y
Sbjct: 256 GGIAEEALASTHIVKAYNAASKLQARYDSYLERATQLGVKRGPIRGIQYGAQFAIMFCAY 315
Query: 2798 AAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNM 2977
A A+ +G+ L+ K + ++ VL ++ ++ + E K AA +F +
Sbjct: 316 ALAWFYGIRLLV-KGEIESGGYLITVLTSVLIGSQSLTLIGPFIGEVSKTAAAAQELFQV 374
Query: 2978 LEEEPRIDGMTSSG-TYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGP 3154
++ +P ID ++S G T ++G + V F YP RP+V +L + V + G+T A+VG
Sbjct: 375 IDRKPNIDSLSSDGRTLTGVTGHISFRNVSFAYPSRPSVRVLDDVTVDFEAGKTTAIVGS 434
Query: 3155 SGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENI 3334
SG GKST+++L+ R +DP+ G+V +D + + ++N + LR I V QEP+LF SI N+
Sbjct: 435 SGSGKSTILALVSRFFDPVSGSVLLDGHPIHELNIRWLRGQIGSVQQEPVLFSESIFANV 494
Query: 3335 VYG-------LQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRI 3493
+G L P +++ AC A H FI LP+ Y+T VG LSGGQKQRI
Sbjct: 495 CHGFFRTDMDLLPEHERRIRVQEACEAAFAHHFIQGLPEQYDTPVGAGDGLLSGGQKQRI 554
Query: 3494 AIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIM 3673
AIAR++IRNP ILLLDEATSALD +E VQ AL+ +K RT I+VAHRLST+ A I+
Sbjct: 555 AIARSIIRNPPILLLDEATSALDPNAEGTVQAALNNVSKTRTTIIVAHRLSTVQRADNIV 614
Query: 3674 VVKNGQVVEQGTHNELIAKRGAYFALTQKQSS----NQSGGAFDTSEA 3805
V++ G+VVEQG+H EL+AK+G YF L Q+ + +G TSEA
Sbjct: 615 VLRKGRVVEQGSHRELLAKKGTYFDLVAAQTEDGIISTAGDQTGTSEA 662
>gi|37695542|gb|AAR00316.1| PGP1; ZMPGP1 [Zea mays]
Length = 1394
Score = 684 bits (1766), Expect = 0.0
Identities = 424/1265 (33%), Positives = 663/1265 (51%), Gaps = 22/1265 (1%)
Frame = +2
Query: 56 LYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAA 235
L+R+ +D ++ +G + + G LP+ ++ +F G+ DP++
Sbjct: 127 LFRFADGLDCALMLIGTLGALVHGCSLPVFLRFFADLVDSF---GSHADDPDTMV----- 178
Query: 236 ARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAW 415
V++ ++ +G I+A+ + + SC+M E+ S R R ++ + +RQ++++
Sbjct: 179 ------RLVVKYAFYFLVVGAAIWASSWAEISCWMWTGERQSTRMRIRYLDAALRQDVSF 232
Query: 416 YDKNTSGT-LSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSL 592
+D + + + + + V++ K+G MA F+ GF V FT W L L+ +++
Sbjct: 233 FDTDVRASDVIYAINADAVVVQDAISQKLGNLIHYMATFVAGFVVGFTAAWQLALVTLAV 292
Query: 593 SPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDAL 772
P + + G + A GIAE+ L IR V AF G+E E + Y AL
Sbjct: 293 VPLIAVIGGLSAAALAKLSSRSQDALSGASGIAEQALAQIRIVQAFVGEEREMRAYSAAL 352
Query: 773 EHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMG 952
++ G + F G GL + ++ Y L W G + V + G + FSVM+G
Sbjct: 353 AVAQRIGYRSGFAKGLGLGGTYFTVFCCYGLLLWYGGHLVRAQHTNGGLAIATMFSVMIG 412
Query: 953 SMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTY 1132
+ Q+ A A AAA ++ +ID P I S +G P ++GR+ + V+F Y
Sbjct: 413 GLPR-QSAPSMAAFAKARVAAAKIFRIIDHRPGIS--SRDGAEPESVTGRVEMRGVDFAY 469
Query: 1133 PTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDF 1312
P+R DV IL+G SL G+T+ALVGSSG GKST++ L++RFY+P AGQIL+D +
Sbjct: 470 PSRPDVPILRGFSLSVPAGKTIALVGSSGSGKSTVVSLIERFYDPSAGQILLDGHDLRSL 529
Query: 1313 NIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSD--EDIARALKEANAADFIKTFPEG 1486
+++LR+ +G+VSQEP LF TSI +N+ GR S ++ A + ANA FI P+G
Sbjct: 530 ELRWLRRQIGLVSQEPALFATSIRENLLLGRDSQSATLAEMEEAARVANAHSFIIKLPDG 589
Query: 1487 LNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRG 1666
+T VG+RG+Q+SGGQKQRIAIARA+++NP ILLLDEATSALD+ESE +VQ AL+ G
Sbjct: 590 YDTQVGERGLQLSGGQKQRIAIARAMLKNPAILLLDEATSALDSESEKLVQEALDRFMMG 649
Query: 1667 RTTI-VIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIE--QKGLYHELVHAQVFADVDD 1837
RTT+ A AD + V++ G V E+ H+ L+ + G Y +L+ Q A
Sbjct: 650 RTTLGDRATGCPPSAKADVVAVLQGGAVSEMSAHDELMAKGENGTYAKLIRMQEQA---H 706
Query: 1838 KPKKKEAERRMSRQTSQRKG-SVNFKTQESQVDXXXXXXXXXXXXXXXXXXX-------- 1990
+ A R +R +S R S T+ S
Sbjct: 707 EAALVNARRSSARPSSARNSVSSPIMTRNSSYGRSPYSRRLSDFSTSDFTLSIHDPHHHH 766
Query: 1991 XXXXXXXGAVKANLFKILRYAR---PEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFS 2161
A +A LR AR PEW Y ++ G+ F+ S +++V+
Sbjct: 767 RTMADKQLAFRAGASSFLRLARMNSPEWAYALAGSIGSMVCGSFSAIFAYILSAVLSVYY 826
Query: 2162 NPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDA 2341
PD MK++ + + + +++ Q + E LT R+R K++ V R +
Sbjct: 827 APDPRYMKREIAKYCYLLIGMSSAALLFNTVQHVFWDTVGENLTKRVREKMFAAVFRNEI 886
Query: 2342 TYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLV 2521
+FD +++ R+T RLA DA N++SAI R+ I A + F W++A ++
Sbjct: 887 AWFDADENASARVTARLALDAQNVRSAIGDRISVIVQNSALMLVACTAGFVLQWRLALVL 946
Query: 2522 MAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFC 2701
+A+FP + L + G + A + A EA+ N+RTV A + K+ +F
Sbjct: 947 LAVFPLVVGATVLQKMFMKGFSGDLEAAHARATQIAGEAVANLRTVAAFNAERKITGLFE 1006
Query: 2702 SHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLF 2881
++L P K I G YG A + + +YA + +L+ K+ + + +RV
Sbjct: 1007 ANLRGPLRRCFWKGQIAGSGYGVAQFLLYASYALGLWYAAWLV--KHGVSDFSRTIRVFM 1064
Query: 2882 AISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGM-TSSGTYPQLSG-EVKLN 3055
+ S + P++IK A +F ++ + ++ + P G +V+L
Sbjct: 1065 VLMVSANGAAETLTLAPDFIKGGRAMRSVFETIDRKTEVEPHDVDAAPVPDGPGAKVELK 1124
Query: 3056 KVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDN 3235
V F YP RP + + + L++ + G+TLALVGPSG GKS+V++L++R Y P G V +D
Sbjct: 1125 HVDFLYPSRPDIQVFRDLSLRARAGKTLALVGPSGSGKSSVLALVQRFYKPTSGRVLLDG 1184
Query: 3236 NDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFI 3415
D+R+ N + LR+ +A+V QEP LF SI ENI YG + T ++ A ++AN H+FI
Sbjct: 1185 KDVRKYNLRALRRVVAVVPQEPFLFAASIHENIAYGREGA--TEAEVVEAAAQANAHRFI 1242
Query: 3416 DELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVAL 3595
LP+GY T+VGE+G QLSGGQ+QRIAIARAL++ I+LLDEATSALD ESE+ VQ AL
Sbjct: 1243 AALPEGYRTQVGERGVQLSGGQRQRIAIARALVKQAAIVLLDEATSALDAESERCVQEAL 1302
Query: 3596 DAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKR--GAYFALTQKQSS 3769
+ A RT IVVAHRL+T+ A I V+ +G+V EQG+H+ L+ G Y + Q ++
Sbjct: 1303 ERAGSGRTTIVVAHRLATVRGAHTIAVIDDGKVAEQGSHSHLLKHHPDGCYARMLQLAAA 1362
Query: 3770 NQSGG 3784
+ GG
Sbjct: 1363 DGRGG 1367
>gi|7442649|pir||T06165 multidrug resistance protein 1 homolog -
barley
gi|2292907|emb|CAA71179.1| P-glycoprotein homologue [Hordeum vulgare
subsp. vulgare]
Length = 1232
Score = 679 bits (1753), Expect = 0.0
Identities = 420/1246 (33%), Positives = 646/1246 (51%), Gaps = 6/1246 (0%)
Frame = +2
Query: 44 SIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTAS 223
SI L+++ VD +++A+G + + G L+ I +V + L
Sbjct: 17 SIRGLFKFADRVDVVLMALGTLGAIGDGCSTNLLLIFASDVMNS--------LGRGHAQQ 68
Query: 224 EKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQ 403
+ +A A F H++ ++CL +VYL I ++ C+ E+ R R + +++RQ
Sbjct: 69 QGSATSAHFMHDIEKSCLNFVYLAFAILVVASMEGYCWSRTSERQVLRIRHLYLEAILRQ 128
Query: 404 EIAWYDKN--TSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
E+A++D T+ + N + + ++E +KV L F+ G A + + W L L
Sbjct: 129 EVAFFDSQEATTSEIINSISKDASLIQEVLSEKVPLFLMHSTVFVSGLAFSTYFSWRLAL 188
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
+ L ++I GL +YA A + E+ L SI+TV +F ++ +R
Sbjct: 189 VSYPLVLLLIIPGLIYGKYLLYLSRESRREYAKANSLVEQALGSIKTVYSFTAEKGIIQR 248
Query: 758 YEDALEHGKKTGIKKSFLIGAGLASFFV-IIYASYCLAFWVGTNFVYSGRLESGTVLTVF 934
Y L+ GIK+ I GLA F + +A + W G+ V G +
Sbjct: 249 YTAILDKTINLGIKQG--IAKGLAVGFTGLSFAIWAFLAWYGSRLVMYHHESGGRIYAAG 306
Query: 935 FSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVN 1114
S ++G ++LG A + A AA + E I+R+P+I+ +G ++ G I
Sbjct: 307 ISFVLGGLSLGMALPELKHFIEASVAATRILERINRVPQINDDDPKGLVLDQVRGEIEFE 366
Query: 1115 KVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDD 1294
+ F YP+R ++ +LK +L GQT+ALVGSSG GKST I L+QRFY+ G + +D
Sbjct: 367 SIRFVYPSRPNMTVLKDFNLQIPAGQTIALVGSSGSGKSTAIALVQRFYDASEGTVKVDG 426
Query: 1295 IPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKT 1474
I I+ N+K +R +G+VSQ+ LF TSI++NI +G+ D + + + A ANA +FI
Sbjct: 427 IDIKKLNLKSIRSKIGLVSQDHALFGTSIKENILFGKPDATMDLLYAAAMTANAHNFIMG 486
Query: 1475 FPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALEN 1654
PEG T +G+RG +SGGQKQRIAIARA+++NP ILLLDEATSALD+ESE +VQ AL+
Sbjct: 487 LPEGYETKIGERGALLSGGQKQRIAIARAVLKNPAILLLDEATSALDSESEKLVQHALDQ 546
Query: 1655 ASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVD 1834
AS GRTT+V+AH+LSTV+NAD+I V+ G++ E+GTH+ LI + G Y LV Q
Sbjct: 547 ASMGRTTLVVAHKLSTVKNADQIAVVDGGRIAEIGTHDELINKGGPYSRLVKLQKMVSYI 606
Query: 1835 DKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXG 2014
D ++T Q + S +T S++
Sbjct: 607 D------------QETDQFRASSAARTSASRL-----SMSRASPMPLTPGFSKETESYVS 649
Query: 2015 AVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDG 2194
+ ++L PEW L+ G++ P ++L +I F D ++M
Sbjct: 650 PPAPSFSRLLAMNAPEWKQALIGSISALVYGSLQPTYALTIGGMIAAFFVQDHNEMNAII 709
Query: 2195 HFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPG 2374
+AL+F L+ V L Q F E L RIR +V +L +A +FD +S G
Sbjct: 710 SRYALIFCSLSLVSIAVNLLQHYNFAYMGEHLVRRIRVQVLEKILTFEAAWFDEDTNSSG 769
Query: 2375 RITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQ 2554
+ +RL+ ++ +K+ + R+ + + + + W++A +++A+ P +
Sbjct: 770 SLCSRLSDESSLVKTLVADRISLLLQTACGIVIAVTMGLIVAWKLALVMIAVQPCTMICY 829
Query: 2555 ALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNI 2734
+ AK + + A+EA+ N R V + +K+ +F + P
Sbjct: 830 YAKKIVLSNVSRDLAKAQYESTQIAIEAVYNHRMVTSFGCSSKILQLFEHTQEEPLRKAR 889
Query: 2735 SKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGF 2914
K+ + G+T G + + F ++A F +G L + +V + F + + I
Sbjct: 890 KKSWVAGITTGLSPCLTFLSWALDFWYGGKLAQSGEI--SAGDVFKTFFVLVSTGKLIAD 947
Query: 2915 AASYFPEYIKATFAAGLIFNMLEEE---PRIDGMTSSGTYPQLSGEVKLNKVFFRYPERP 3085
A S + K A +F +L+ + P+ + ++ G ++ KV F YP RP
Sbjct: 948 AGSMTSDLAKGANAVASVFEVLDRKSISPQNSQVEKDNPKSKIQGRIEFKKVDFSYPTRP 1007
Query: 3086 AVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKH 3265
ILQ ++ VK G ++ LVG SGCGKST+I L++R YD GAV +D D+R+MN
Sbjct: 1008 QCLILQDFSLDVKAGTSIGLVGRSGCGKSTIIGLIQRFYDVDRGAVRIDGVDVREMNVLW 1067
Query: 3266 LRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETR 3445
R ALVSQEP +F S+R+NI +G E E+I A AN H+FI L DGY+T
Sbjct: 1068 YRGFTALVSQEPAMFSGSVRDNIAFG--KPEADEEEIVEAAKAANAHEFISSLKDGYDTD 1125
Query: 3446 VGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCI 3625
GE G QLSGGQKQRIAIARA+IRNP ILLLDEATSALD +SE+ VQ ALD RT I
Sbjct: 1126 CGEHGIQLSGGQKQRIAIARAIIRNPAILLLDEATSALDAQSEQVVQEALDRIMTGRTTI 1185
Query: 3626 VVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQ 3763
+VAHRL+TI NA I + G+V+E+GT+ +L+ K+GA+F L Q
Sbjct: 1186 IVAHRLNTIKNADSIAFLGEGKVIERGTYPQLMNKKGAFFNLATLQ 1231
>gi|38098857|gb|AAR11078.1| ATP binding cassette transporter
[Leptosphaeria maculans]
gi|46403062|gb|AAS92552.1| SirA [Leptosphaeria maculans]
Length = 1263
Score = 679 bits (1752), Expect = 0.0
Identities = 413/1261 (32%), Positives = 646/1261 (50%), Gaps = 19/1261 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNF--VTLGTIFLDPNS 214
I+ F L+RY + + +L + + +G PL+ + +GN+ Q LGTI
Sbjct: 39 INYFSLFRYATVKEYALLLISAFFAAVSGAMFPLLILFIGNLVQVLKDFNLGTI------ 92
Query: 215 TASEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSV 394
+ + S ++ L VYL G + F+ + +++ E ++N R ++ S+
Sbjct: 93 -------PQEQLSEQIRDIALYIVYLFLGQLVSVFIFTNGCLLVGEAITNAIREKYVRSL 145
Query: 395 MRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLT 574
RQ IA++D SG ++++L + +++ K+GL + F+ +A+ F W LT
Sbjct: 146 FRQNIAFFDTYGSGKITSQLTSSTATIQDAISHKIGLFVSACSCFVASYAIGFVKHWKLT 205
Query: 575 LIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECK 754
I+ S + + A A EE + IR V A ++
Sbjct: 206 FILTSTVVAITGVMIIMSGFMAKFGANSSGALAEASAKLEETFSGIRVVKALGLEKRLSD 265
Query: 755 RYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVF 934
+ L + + G + ++G LA + +I+ +Y LA W G F+ G + G ++TV
Sbjct: 266 ELDPQLLNIEFWGKRVRHVMGWMLAIMYGLIFLNYGLAIWQGYRFMQGGTEDVGAIITVL 325
Query: 935 FSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVN 1114
+ +G+ G G + AA ++ VI+R D + G ++ G I
Sbjct: 326 MCLNIGAFLFGNVGPHLQAMSLGAAAAQDIFAVIERESVTDGGAPPGSF--EVEGNIEFR 383
Query: 1115 KVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDD 1294
V YP+R D +L+ S+ G+ A+VG+SG GKSTI+ +L+RFY P +GQ+ +D
Sbjct: 384 NVSHVYPSRPDTHVLQDFSMIFPAGKVTAIVGASGSGKSTIVSILERFYEPVSGQVFLDG 443
Query: 1295 IPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRS---------DVSDEDIARALKE 1447
I N+++LRQ G+V QEP LFN SI +N+ YG +V+ + + A +
Sbjct: 444 HDITHLNVQWLRQQFGLVGQEPVLFNGSIFKNVAYGLKGTQYGQESREVTMKLVTEACRI 503
Query: 1448 ANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESE 1627
ANA DFI P G + VG RG +SGGQ+QRIAIARA+V PKILLLDEATSALD +SE
Sbjct: 504 ANAHDFITALPHGYDQEVGIRGASLSGGQRQRIAIARAIVSGPKILLLDEATSALDVQSE 563
Query: 1628 SIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELV 1807
VQ L AS GRTTIV+AH LST++ AD IIVM+ G+V + GTH L Q+GLY V
Sbjct: 564 EAVQLGLNMASSGRTTIVVAHSLSTIKLADNIIVMEKGRVAQQGTHAELEAQEGLYQTFV 623
Query: 1808 HAQVFADVDDKPKKK------EAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXX 1969
Q +P + + S++ GS+ + + D
Sbjct: 624 RRQQLKQATLEPPHARITPAVDTPASPQHRLSEKTGSIYGQGESEAADKSPSTKYSF--- 680
Query: 1970 XXXXXXXXXXXXXXGAVKANLFK-ILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQI 2146
L K + R+ + +W +I GAV PA S+FF++
Sbjct: 681 ------------------VQLVKFVARFNKEDWRLMVTGIASAVISGAVWPAHSVFFAKA 722
Query: 2147 INVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNV 2326
I S+P + + +FWA M+++LA VQ S Q S F + AERL +R R ++ +
Sbjct: 723 IVALSSPSPASLARGPNFWAAMYVMLAFVQIASQGVQGSAFAICAERLILRARRVAFKYL 782
Query: 2327 LRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQ 2506
LRQD +FD P HS G +T+ +++D + LG++F+A A+V GGL ++ GW+
Sbjct: 783 LRQDVEFFDDPLHSSGIMTSFVSSDVNALAGLSGVFLGTLFSATATVLGGLILSLAVGWK 842
Query: 2507 MAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKL 2686
+ + M P + V + +K G K E + E I +RTV A L+ ++
Sbjct: 843 LTLVTMGTIPIIIVAGYVRLKLVGTLEKISRKVHEESAGRVCEEINAVRTVAASCLEDEM 902
Query: 2687 YNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENV 2866
+ L + + + Y + ++ + F +G L+ E +
Sbjct: 903 CEDYVRSLKSKEKTYLRATLWSSGWYALSEAVPLGCMSLGFWYGATLVMRTEYTTEQFFI 962
Query: 2867 LRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLS-GE 3043
V+ A+ F + G ++ P++ KA +A + +++ +P +D + G + + + G+
Sbjct: 963 --VVTAVIFGASSAGLVFAFAPDFGKAGVSAERLQELVDRQPEVDTWSEEGDHIETTNGK 1020
Query: 3044 VKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAV 3223
V ++ V F Y +R P+L +++ PGQ++ L G SG GKSTV SLLER Y+P G V
Sbjct: 1021 VDVSNVVFYYNQRSKTPVLNSISLGAAPGQSIGLCGGSGSGKSTVASLLERFYNPSSGTV 1080
Query: 3224 TVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANI 3403
++D D+R +N R ALV+QEP+LF SIREN++YG + T +IE AC A +
Sbjct: 1081 SLDEKDVRTININSYRAQFALVNQEPLLFSCSIRENLLYGSLGKDLTDSEIEEACKMAQV 1140
Query: 3404 HKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQV 3583
+ F+ LP+G +T G LSGGQ+QR++IARA++R P++L+LDEATSALD+ SE+ V
Sbjct: 1141 YDFVCSLPEGLDTSFGSNAVMLSGGQRQRLSIARAILRKPRVLILDEATSALDSTSERAV 1200
Query: 3584 QVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQ 3763
AL A+ RT I+VAHRLSTI I ++ G V E+GTH EL+AKRG+Y+ Q
Sbjct: 1201 IEALTKTAEGRTTIMVAHRLSTIQGCDKIFYLRAGAVAEEGTHEELMAKRGSYYDSVNLQ 1260
Query: 3764 S 3766
S
Sbjct: 1261 S 1261
Score = 298 bits (762), Expect = 9e-79
Identities = 204/608 (33%), Positives = 307/608 (49%), Gaps = 21/608 (3%)
Frame = +2
Query: 2018 VKANLFKILRYAR-PEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPD-----RDQ 2179
+K N F + RYA E+ + GA+ P LF ++ V + + ++Q
Sbjct: 37 IKINYFSLFRYATVKEYALLLISAFFAAVSGAMFPLLILFIGNLVQVLKDFNLGTIPQEQ 96
Query: 2180 MKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMP 2359
+ + AL + L Q S+ + + E +T IR K R++ RQ+ +FD
Sbjct: 97 LSEQIRDIALYIVYLFLGQLVSVFIFTNGCLLVGEAITNAIREKYVRSLFRQNIAFFDT- 155
Query: 2360 KHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFL----VMA 2527
+ G+IT++L + I+ AI +++G +A + I F W++ F+ V+A
Sbjct: 156 -YGSGKITSQLTSSTATIQDAISHKIGLFVSACSCFVASYAIGFVKHWKLTFILTSTVVA 214
Query: 2528 IFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSH 2707
I M + M K+ S+ + A+ A E IR V+AL L+ +L +
Sbjct: 215 ITGVMIIMSGFMAKFGANSSGALAE----ASAKLEETFSGIRVVKALGLEKRLSDELDPQ 270
Query: 2708 LDAPHGGNISKAIIRGLTYGFANSIQFFTYAAA----FRFGLFLIFDKNVLMEPENVLRV 2875
L + G + F Y A +RF D ++ VL
Sbjct: 271 LLNIEFWGKRVRHVMGWMLAIMYGLIFLNYGLAIWQGYRFMQGGTEDVGAII---TVLMC 327
Query: 2876 LFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLN 3055
L +F FG +G + AA IF ++E E DG G++ ++ G ++
Sbjct: 328 LNIGAFLFGNVG---PHLQAMSLGAAAAQDIFAVIERESVTDGGAPPGSF-EVEGNIEFR 383
Query: 3056 KVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDN 3235
V YP RP +LQ ++ G+ A+VG SG GKST++S+LER Y+P+ G V +D
Sbjct: 384 NVSHVYPSRPDTHVLQDFSMIFPAGKVTAIVGASGSGKSTIVSILERFYEPVSGQVFLDG 443
Query: 3236 NDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIET-------ACSK 3394
+D+ +N + LR+ LV QEP+LF+ SI +N+ YGL+ +Y E E AC
Sbjct: 444 HDITHLNVQWLRQQFGLVGQEPVLFNGSIFKNVAYGLKGTQYGQESREVTMKLVTEACRI 503
Query: 3395 ANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESE 3574
AN H FI LP GY+ VG +G LSGGQ+QRIAIARA++ PKILLLDEATSALD +SE
Sbjct: 504 ANAHDFITALPHGYDQEVGIRGASLSGGQRQRIAIARAIVSGPKILLLDEATSALDVQSE 563
Query: 3575 KQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALT 3754
+ VQ+ L+ A+ RT IVVAH LSTI A I+V++ G+V +QGTH EL A+ G Y
Sbjct: 564 EAVQLGLNMASSGRTTIVVAHSLSTIKLADNIIVMEKGRVAQQGTHAELEAQEGLYQTFV 623
Query: 3755 QKQSSNQS 3778
++Q Q+
Sbjct: 624 RRQQLKQA 631
>gi|25297460|pir||B86240 protein F20B24.12 [imported] - Arabidopsis
thaliana
gi|6573748|gb|AAF17668.1| F20B24.12 [Arabidopsis thaliana]
Length = 1316
Score = 677 bits (1747), Expect = 0.0
Identities = 438/1341 (32%), Positives = 679/1341 (49%), Gaps = 100/1341 (7%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+S +L+ + D +++A+G I +C G +P+ I G + +G +L P
Sbjct: 24 VSFLKLFSFADFYDCVLMALGSIGACIHGASVPVFFIFFGKLIN---IIGLAYLFPQ--- 77
Query: 221 SEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMR 400
E SH+V + L +VYL I + +L+ +C+M E+ + + R+ + S++
Sbjct: 78 --------EASHKVAKYSLDFVYLSVVILFSSWLEVACWMHTGERQAAKIRKAYLRSMLS 129
Query: 401 QEIAWYDKNTS-GTLSNKLFDNLERVREGTGDKV-------------------------- 499
Q+I+ +D S G + + + + V++ +KV
Sbjct: 130 QDISLFDTEISTGEVISAITSEILVVQDAISEKVRYTKIKPVLVLNFGCWIFNFPIASMH 189
Query: 500 --GLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYA 673
G +++FI GFA+ F W ++L+ +S+ PF+ + G Y
Sbjct: 190 LVGNFMHFISRFIAGFAIGFASVWQISLVTLSIVPFIALAGGIYAFVSSGLIVRVRKSYV 249
Query: 674 VAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYA 853
A IAEEV+ ++RTV AF G+E Y+ AL + G K G GL S +++
Sbjct: 250 KANEIAEEVIGNVRTVQAFTGEEKAVSSYQGALRNTYNYGRKAGLAKGLGLGSLHFVLFL 309
Query: 854 SYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSM---------ALGQAGQQFATIGTAL 1006
S+ L W + V+ G G T +V++ +LGQA +T A
Sbjct: 310 SWALLIWFTSIVVHKGIANGGESFTTMLNVVIAGFHNKALFLYRSLGQAAPDISTFMRAS 369
Query: 1007 GAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKGVSLDAQP 1186
AA ++++I+R E G+ ++G I V FTYP+R DV I ++
Sbjct: 370 AAAYPIFQMIERNTE----DKTGRKLGNVNGDILFKDVTFTYPSRPDVVIFDKLNFVIPA 425
Query: 1187 GQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNL 1366
G+ VALVG SG GKST+I L++RFY P G +++D I ++K+LR +G+V+QEP L
Sbjct: 426 GKVVALVGGSGSGKSTMISLIERFYEPTDGAVMLDGNDIRYLDLKWLRGHIGLVNQEPVL 485
Query: 1367 FNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEGLNTLV--------------- 1501
F T+I +NI YG+ D + E+I A K + A FI PEG T V
Sbjct: 486 FATTIRENIMYGKDDATSEEITNAAKLSEAISFINNLPEGFETQVCRTSDSLEHKKLTTV 545
Query: 1502 ------------GDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSA 1645
G+RG+Q+SGGQKQRI+I+RA+V+NP ILLLDEATSALDAESE IVQ A
Sbjct: 546 NPRFCLLFGLQVGERGIQLSGGQKQRISISRAIVKNPSILLLDEATSALDAESEKIVQEA 605
Query: 1646 LENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQK-GLYHELVHAQVF 1822
L+ GRTT+V+AHRLSTVRNAD I V+ G+++E G+H+ LI G Y L+ Q
Sbjct: 606 LDRVMVGRTTVVVAHRLSTVRNADIIAVVGGGKIIESGSHDELISNPDGAYSSLLRIQEA 665
Query: 1823 A--DVDDKPK-----KKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXX 1981
A +++ P K E ++ TS SVN Q
Sbjct: 666 ASPNLNHTPSLPVSTKPLPELPITETTSSIHQSVNQPDTTKQA----------------- 708
Query: 1982 XXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFS 2161
K + ++ RP+W Y I G+ MP F+L +Q + V
Sbjct: 709 -------------KVTVGRLYSMIRPDWKYGLCGTLGSFIAGSQMPLFALGIAQAL-VSY 754
Query: 2162 NPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDA 2341
D + + + +++F + + + + FG+ ERLT+R+R K++ +LR +
Sbjct: 755 YMDWETTQNEVKRISILFCCGSVITVIVHTIEHTTFGIMGERLTLRVRQKMFSAILRNEI 814
Query: 2342 TYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLV 2521
+FD ++ + +RL +DA +++ + R + + V I+F W++ +V
Sbjct: 815 GWFDKVDNTSSMLASRLESDATLLRTIVVDRSTILLENLGLVVTAFIISFILNWRLTLVV 874
Query: 2522 MAIFPFMAVG-------------------QALMMKYHGGSATSDAKEMENAGKTAMEAIE 2644
+A +P + G Q + M+ +GG+ + K A A E+I
Sbjct: 875 LATYPLIISGHISEVKRSFLRFYILFFGRQKIFMQGYGGNLS---KAYLKANMLAGESIS 931
Query: 2645 NIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLF 2824
NIRTV A + K+ +++ L P + + + G+ YG + F +Y A +
Sbjct: 932 NIRTVVAFCAEEKVLDLYSKELLEPSERSFRRGQMAGILYGVSQFFIFSSYGLALWYIYK 991
Query: 2825 LIFDK--NVLMEP-----ENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLE 2983
L K ++LME E+V++ + + +G + P+ +K +F +L+
Sbjct: 992 LFHTKYGSILMEKGLSSFESVMKTFMVLIVTALVMGEVLALAPDLLKGNQMVVSVFELLD 1051
Query: 2984 EEPRIDGMTSSGTYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGC 3163
++ G T + G ++L V F YP RP V I N+ V G+++ALVG SG
Sbjct: 1052 RRTQVVGDTGE-ELSNVEGTIELKGVHFSYPSRPDVTIFSDFNLLVPSGKSMALVGQSGS 1110
Query: 3164 GKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYG 3343
GKS+V+SL+ R YDP G + +D D++++ K LR+HI LV QEP LF T+I ENI+YG
Sbjct: 1111 GKSSVLSLVLRFYDPTAGIIMIDGQDIKKLKLKSLRRHIGLVQQEPALFATTIYENILYG 1170
Query: 3344 LQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNP 3523
+ + ++ A AN H FI LP+GY T+VGE+G Q+SGGQ+QRIAIARA+++NP
Sbjct: 1171 KEGA--SESEVMEAAKLANAHSFISSLPEGYSTKVGERGIQMSGGQRQRIAIARAVLKNP 1228
Query: 3524 KILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQ 3703
+ILLLDEATSALD ESE+ VQ ALD +DRT +VVAHRLSTI N+ I V+++G+++EQ
Sbjct: 1229 EILLLDEATSALDVESERVVQQALDRLMRDRTTVVVAHRLSTIKNSDMISVIQDGKIIEQ 1288
Query: 3704 GTHNELIA-KRGAYFALTQKQ 3763
G+HN L+ K G Y L Q
Sbjct: 1289 GSHNILVENKNGPYSKLISLQ 1309
Score = 304 bits (778), Expect = 1e-80
Identities = 213/627 (33%), Positives = 321/627 (50%), Gaps = 70/627 (11%)
Frame = +2
Query: 2099 IQGAVMPAFSLFFSQIINV------FSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQC 2260
I GA +P F +FF ++IN+ F ++ K ++L F+ L+ V S +
Sbjct: 50 IHGASVPVFFIFFGKLINIIGLAYLFPQEASHKVAK----YSLDFVYLSVVILFSSWLEV 105
Query: 2261 SLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAID---- 2428
+ + ER +IR R++L QD + FD + S G + + + ++ ++ AI
Sbjct: 106 ACWMHTGERQAAKIRKAYLRSMLSQDISLFD-TEISTGEVISAITSEILVVQDAISEKVR 164
Query: 2429 ------------------------YRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFP 2536
+ +G+ + I+ G I F WQ++ + ++I P
Sbjct: 165 YTKIKPVLVLNFGCWIFNFPIASMHLVGNFMHFISRFIAGFAIGFASVWQISLVTLSIVP 224
Query: 2537 FMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDA 2716
F+A+ + G K A + A E I N+RTVQA T + K + + L
Sbjct: 225 FIALAGGIYAFVSSGLIVRVRKSYVKANEIAEEVIGNVRTVQAFTGEEKAVSSYQGALRN 284
Query: 2717 PHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPEN---VLRVLFA- 2884
+ + +GL G + + F ++A F ++ K + E+ +L V+ A
Sbjct: 285 TYNYGRKAGLAKGLGLGSLHFVLFLSWALLIWF-TSIVVHKGIANGGESFTTMLNVVIAG 343
Query: 2885 ----ISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKL 3052
F + ++G AA +++A+ AA IF M+E G ++G++
Sbjct: 344 FHNKALFLYRSLGQAAPDISTFMRASAAAYPIFQMIERNTEDKTGRKLG---NVNGDILF 400
Query: 3053 NKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVD 3232
V F YP RP V I LN + G+ +ALVG SG GKST+ISL+ER Y+P +GAV +D
Sbjct: 401 KDVTFTYPSRPDVVIFDKLNFVIPAGKVVALVGGSGSGKSTMISLIERFYEPTDGAVMLD 460
Query: 3233 NNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKF 3412
ND+R ++ K LR HI LV+QEP+LF T+IRENI+YG + T E+I A + F
Sbjct: 461 GNDIRYLDLKWLRGHIGLVNQEPVLFATTIRENIMYG--KDDATSEEITNAAKLSEAISF 518
Query: 3413 IDELPDGYET---------------------------RVGEKGTQLSGGQKQRIAIARAL 3511
I+ LP+G+ET +VGE+G QLSGGQKQRI+I+RA+
Sbjct: 519 INNLPEGFETQVCRTSDSLEHKKLTTVNPRFCLLFGLQVGERGIQLSGGQKQRISISRAI 578
Query: 3512 IRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQ 3691
++NP ILLLDEATSALD ESEK VQ ALD RT +VVAHRLST+ NA I VV G+
Sbjct: 579 VKNPSILLLDEATSALDAESEKIVQEALDRVMVGRTTVVVAHRLSTVRNADIIAVVGGGK 638
Query: 3692 VVEQGTHNELIAK-RGAYFALTQKQSS 3769
++E G+H+ELI+ GAY +L + Q +
Sbjct: 639 IIESGSHDELISNPDGAYSSLLRIQEA 665
>gi|27368869|emb|CAD59592.1| MDR-like ABC transporter [Oryza sativa
(japonica cultivar-group)]
Length = 1279
Score = 677 bits (1746), Expect = 0.0
Identities = 426/1300 (32%), Positives = 666/1300 (50%), Gaps = 60/1300 (4%)
Frame = +2
Query: 44 SIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTAS 223
S +L RY DR ++A+G++ S G+ PL +++G++ ++ A
Sbjct: 8 SFLRLVRYADAHDRCLMALGVLGSFGDGMMQPLSMLVLGDIVNSY-----------GGAG 56
Query: 224 EKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQ 403
+AR+ FS + L C+ E+ +++ RR + +V+ Q
Sbjct: 57 GAGSARSAFSSGAVDKGL------------------CWTRTAERQASKMRRLYLEAVLSQ 98
Query: 404 EIAWYDKNTSGTLS-------------NKLFDNLERVREGTGDKVGLAFQMMAQFIGGFA 544
E+A++D S S + + D+ + +++ G+K+ + F G A
Sbjct: 99 EVAFFDAAPSSPSSPQAQAQATTFRVISTVSDDADAIQDFLGEKLPMVLANATLFFGALA 158
Query: 545 VAFTYDWLLTL------IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLT 706
V+F + W L L +++ ++P +++ G Y AGGIA++ ++
Sbjct: 159 VSFVFAWRLALAGLPFTLLLFVTPSVLLAGRMAAAAGEARAA-----YEEAGGIAQQAVS 213
Query: 707 SIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTN 886
SIRTV ++ + +R+ A+ G+++ + GA + S VI YA + W+G+
Sbjct: 214 SIRTVASYTAERRTVERFRGAVARSAALGVRQGLIKGAVIGSMGVI-YAVWSFLSWIGSL 272
Query: 887 FVYSGRLESGTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYS 1066
V + G V +++ M++ A A AA+ + E+I+ +P ++
Sbjct: 273 LVIHLHAQGGHVFVASICIVLAGMSIMMALPNLRYFIDATAAASRMQEMIEMLPPLEGAE 332
Query: 1067 TEGQTPSKISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQL 1246
+G T +I G I V F+YP+R D +L G +L G TV LVG SG GKST+I L
Sbjct: 333 KKGATMERIRGEIVFKDVHFSYPSRPDTLVLNGFNLTISEGATVGLVGGSGSGKSTVISL 392
Query: 1247 LQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDED 1426
LQRFY+PD+G+I +DD I+ N+++LR +G+VSQEP LF TSI +NI +G S +
Sbjct: 393 LQRFYSPDSGEISMDDHGIDTLNVEWLRSQIGLVSQEPVLFATSIRENILFGDETASLKQ 452
Query: 1427 IARALKEANAADFIKTFPEGLNT---------------------------LVGDRGVQMS 1525
+ A K ANA +FI P G T VG G Q+S
Sbjct: 453 VVAAAKMANAHEFIVKLPHGYETHVHKQQQFLQCMLQHAESYGVFFFSPVQVGQFGTQLS 512
Query: 1526 GGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLSTV 1705
GGQKQRIAIARALVR+P+ILLLDEATSALDAESE VQ AL+ AS GRTT+++AHRLST+
Sbjct: 513 GGQKQRIAIARALVRDPRILLLDEATSALDAESERTVQDALDRASVGRTTVIVAHRLSTL 572
Query: 1706 RNADKIIVMKAGQVMEVGTHETLI-----EQKGLYHELVHAQVFADVDDKPKKKEA-ERR 1867
R AD I V+ AG+V+E GTH+ L+ + G+Y +VH Q V + ++ A +
Sbjct: 573 RKADTIAVLDAGRVVEAGTHDELLGMDDGGEGGVYARMVHLQKAPPVAAREERHRAVDVV 632
Query: 1868 MSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXGAVKANLFKILR 2047
S S R + ++ + K + ++L+
Sbjct: 633 ESEMVSFRSVEIMSAVSATEHRPSPAPSFCSVEHSTEIGRKLVDHGVARSRKPSKLRLLK 692
Query: 2048 YARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHFWALMFLVLA 2227
RPEW ++ GAV+P +S + V+ D Q++ + +FL +A
Sbjct: 693 MNRPEWKQALLGCVGAVVFGAVLPLYSYSLGSLPEVYFLADDGQIRSKTRLYYFLFLGIA 752
Query: 2228 AVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAP 2407
V T+ + Q F V ERLT R+R ++ +L + +FD ++S + RLAT +
Sbjct: 753 VVCITANIVQHYNFAVMGERLTERVRGQMLAKILSFEVGWFDEDENSSAAVCARLATQSS 812
Query: 2408 NIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSA 2587
++S + R+ + A A+ G +A W++A ++MA+ P + + K +
Sbjct: 813 KVRSLVGDRMCLLVQAGATASLGFSLALAVSWRLATVMMAMQP-LIIASFYFKKVLMAAM 871
Query: 2588 TSDAKEMENAG-KTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTY 2764
+ AK+ + G + A EA+ N RT+ A + Q ++ ++ + P N++ + G
Sbjct: 872 SKKAKKAQVQGSQLASEAVVNHRTITAFSSQRRMLRLYEAAQQGPKKDNVAHSWFSGFCL 931
Query: 2765 GFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIK 2944
+ A A +G L+ L+ P ++ +V F + I A S + +
Sbjct: 932 CLCQFSNTGSMAVALWYGGKLM--AKGLITPTHLFQVFFMLMTMGRVIADAGSLTSDLAQ 989
Query: 2945 ATFAAGLIFNMLEEEPRI-----DGMTSSGTYPQLSGEVKLNKVFFRYPERPAVPILQGL 3109
A + + L+ EP I D ++ G ++ V F YP RP V +L G
Sbjct: 990 GGDAVRSVLDTLDREPTIKDDDNDNERKKKKRKEIKGAIEFKNVHFSYPTRPEVAVLAGF 1049
Query: 3110 NVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALV 3289
++ + G+T+ALVGPSG GKSTVI L+ER YD G+V VD D+R + LR +ALV
Sbjct: 1050 SLEIGAGKTVALVGPSGSGKSTVIGLIERFYDAQRGSVLVDGEDIRSYSLARLRSQVALV 1109
Query: 3290 SQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQL 3469
SQEP LF +IR+NI YG T +++ A + AN H FI + GY+TRVGE+G QL
Sbjct: 1110 SQEPTLFSGTIRDNIAYGAAEEHATEDEVARAAALANAHGFISAMERGYDTRVGERGAQL 1169
Query: 3470 SGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLST 3649
SGGQ+QRIA+ARA++++ +ILLLDEATSALD SE+ VQ A+D + RTC+VVAHRLST
Sbjct: 1170 SGGQRQRIALARAVLKDARILLLDEATSALDAASERLVQDAVDRMLRGRTCVVVAHRLST 1229
Query: 3650 IVNAGCIMVVKNGQVVEQGTHNELIA--KRGAYFALTQKQ 3763
+ + I VVK+G+V E+G H+EL+A + G Y+ L + Q
Sbjct: 1230 VEKSDTIAVVKDGRVAERGRHHELLAVGRAGTYYNLIKLQ 1269
>gi|36413607|ref|NP_848654.2| ATP-binding cassette, sub-family B,
member 5; P-glycoprotein ABCB5 [Homo sapiens]
gi|34539755|gb|AAO73470.1| P-glycoprotein ABCB5 [Homo sapiens]
gi|37543520|gb|AAM09027.1| P-glycoprotein [Homo sapiens]
Length = 812
Score = 675 bits (1741), Expect = 0.0
Identities = 372/829 (44%), Positives = 513/829 (61%), Gaps = 1/829 (0%)
Frame = +2
Query: 1283 LIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAAD 1462
++D+ I N+++ R +GVVSQEP LF T+I NI+YGR DV+DE++ RA +EANA D
Sbjct: 1 MVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYD 60
Query: 1463 FIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQS 1642
FI FP NTLVG++G QMSGGQKQRIAIARALVRNPKIL+LDEATSALD+ES+S VQ+
Sbjct: 61 FIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQA 120
Query: 1643 ALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVF 1822
ALE AS+GRTTIV+AHRLST+R+AD I+ +K G + E G H L+ ++GLY+ LV +Q
Sbjct: 121 ALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQ-- 178
Query: 1823 ADVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXX 2002
D K E M+ T ++ S+ + +S
Sbjct: 179 ----DIKKADEQMESMTYSTERKTNSLPLHSVKS-----------IKSDFIDKAEESTQS 223
Query: 2003 XXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQM 2182
+ +L KIL+ +PEW + ++ G V P FS+ F++II +F N D+ +
Sbjct: 224 KEISLPEVSLLKILKLNKPEWPFVVLGTLASVLNGTVHPVFSIIFAKIITMFGNNDKTTL 283
Query: 2183 KKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPK 2362
K D ++++F++L + S Q +G A E LTMR+R ++ +L QD +FD +
Sbjct: 284 KHDAEIYSMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKE 343
Query: 2363 HSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFM 2542
+S G +TT LA D I+ A R+G + ++G + I+F YGW+M FL+++I P +
Sbjct: 344 NSTGGLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVL 403
Query: 2543 AVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPH 2722
AV + G A D +E+++AGK A EA+ENIRT+ +LT + ++ L H
Sbjct: 404 AVTGMIETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQH 463
Query: 2723 GGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFG 2902
KA I G Y F+++ +F YAA FRFG +LI + M PE + V AI++
Sbjct: 464 RNTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLI--QAGRMTPEGMFIVFTAIAYGAM 521
Query: 2903 TIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQL-SGEVKLNKVFFRYPE 3079
IG PEY KA A +F +LE++P ID + G P G ++ +V F YP
Sbjct: 522 AIGKTLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTCEGNLEFREVSFFYPC 581
Query: 3080 RPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNP 3259
RP V IL+GL++ ++ G+T+A VG SGCGKST + LL+RLYDP++G V D D +++N
Sbjct: 582 RPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNV 641
Query: 3260 KHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYE 3439
+ LR IA+V QEP+LF+ SI ENI YG ++I+ A + ANIH FI+ LP+ Y
Sbjct: 642 QWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYN 701
Query: 3440 TRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRT 3619
T+VG KG QLSGGQKQR+AIARAL++ PKILLLDEATSALD +SEK VQ ALD A RT
Sbjct: 702 TQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGRT 761
Query: 3620 CIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQS 3766
C+VV HRLS I NA I+V+ NG++ EQGTH EL+ R YF L QS
Sbjct: 762 CLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNAQS 810
Score = 371 bits (953), Expect = e-101
Identities = 211/579 (36%), Positives = 329/579 (56%), Gaps = 4/579 (0%)
Frame = +2
Query: 92 LAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHEVIQN 271
+ +G + S G P+ SII F + T+F + + T H+
Sbjct: 247 VVLGTLASVLNGTVHPVFSII-------FAKIITMFGNNDKTT---------LKHDAEIY 290
Query: 272 CLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYDK--NTSGTLS 445
+ +V LG F + F+Q + E L+ R R F +++ Q+IAW+D+ N++G L+
Sbjct: 291 SMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLT 350
Query: 446 NKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFX 625
L ++ +++ TG ++G+ Q ++F Y W +T +++S++P + + G+
Sbjct: 351 TILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGMIE 410
Query: 626 XXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKS 805
+ AG IA E L +IRT+++ ++ + YE+ L+ + KK+
Sbjct: 411 TAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSKKA 470
Query: 806 FLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQF 985
+IG+ A IY +Y F G + +GR+ + VF ++ G+MA+G+
Sbjct: 471 QIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGKTLVLA 530
Query: 986 ATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKG 1165
A AA L+ ++++ P ID+ S EG+ P G + +V F YP R DV IL+G
Sbjct: 531 PEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTCEGNLEFREVSFFYPCRPDVFILRG 590
Query: 1166 VSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGV 1345
+SL + G+TVA VGSSGCGKST +QLLQR Y+P GQ+L D + ++ N+++LR + +
Sbjct: 591 LSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQIAI 650
Query: 1346 VSQEPNLFNTSIEQNIRYGRSD--VSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQ 1519
V QEP LFN SI +NI YG + V ++I A AN FI+ PE NT VG +G Q
Sbjct: 651 VPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLKGAQ 710
Query: 1520 MSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAHRLS 1699
+SGGQKQR+AIARAL++ PKILLLDEATSALD +SE +VQ AL+ A GRT +V+ HRLS
Sbjct: 711 LSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVVTHRLS 770
Query: 1700 TVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQ 1816
++NAD I+V+ G++ E GTH+ L+ + +Y +LV+AQ
Sbjct: 771 AIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNAQ 809
>gi|46129276|ref|XP_388999.1| hypothetical protein FG08823.1
[Gibberella zeae PH-1]
gi|42548720|gb|EAA71563.1| hypothetical protein FG08823.1 [Gibberella
zeae PH-1]
Length = 1263
Score = 674 bits (1739), Expect = 0.0
Identities = 430/1275 (33%), Positives = 665/1275 (51%), Gaps = 35/1275 (2%)
Frame = +2
Query: 47 IFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASE 226
+++ +++ +D ++ + +I S A+G +P+M+I+ G + G +DP+
Sbjct: 32 LWRAFQFADRLDWVLNVISLICSIASGAAMPVMAILFGKATGRLADFGGGSVDPD----- 86
Query: 227 KAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQE 406
EF EV L + YL G F ++ + + + + R++ ++R E
Sbjct: 87 ------EFKSEVNSFVLWFTYLFVGKFVLAYVATTAITISGVRTTRVLRQRVLEKLLRTE 140
Query: 407 IAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMM 586
I ++D G+ + +L N+ R+ +G +K+ L Q +A F F VA W L LI +
Sbjct: 141 IWYFDTANVGSPATQLTTNVTRINQGIAEKLSLLVQGLAMFASAFVVAIAVQWKLALITL 200
Query: 587 SLSP-FMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYE 763
++ P F +I G+F ++ A A+EV+ SIRTV AF +RY+
Sbjct: 201 TVVPLFFLIMGVFMSLDAPIEAKVTGI-HSQANVFAQEVMASIRTVHAFWAHGRMSERYD 259
Query: 764 DALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLES-GTVLTVFFS 940
+ L+ G KKS L G +S + +Y+ LAFW G SG ++S GTV TV S
Sbjct: 260 NYLKEAHTHGKKKSLLYGIMSSSTYFCMYSGNALAFWQGFRMYRSGEIDSVGTVFTVVLS 319
Query: 941 VMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKV 1120
V++ S ++G Q + AA+ L+++ D+ +D S EGQ P +G I V +
Sbjct: 320 VLLASSSIGLLYPQIPALVNGAAAASELFQIFDKPSLLDPLSNEGQVPEACNGNIQVENI 379
Query: 1121 EFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIP 1300
F+YP+R + ++LK +SLD G+T A VG+SG GKSTII LL+R+Y P +G++L+D +
Sbjct: 380 SFSYPSRPNTQVLKDISLDIPAGKTTAFVGASGSGKSTIIGLLERWYLPSSGRLLLDGVD 439
Query: 1301 IEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDED--------IARALKEANA 1456
I N+K+ R + +V QEP LF ++ +N+ G +D + A + + A
Sbjct: 440 ISTLNVKWFRSQMALVQQEPVLFRGTVFENVSKGFTDSQKALPLKEQRTLVQEACEASYA 499
Query: 1457 ADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIV 1636
DFI+ G +T +G+RG +SGGQKQRIAIAR++V NPKILLLDEATSALD +E IV
Sbjct: 500 HDFIQNLEHGYDTYLGERGGTLSGGQKQRIAIARSVVSNPKILLLDEATSALDPNAERIV 559
Query: 1637 QSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQ 1816
Q AL S+ RTT+VIAHRLST+R+AD I+V+ GQV+E GTH+ L+ Y L+ AQ
Sbjct: 560 QKALSRVSQQRTTLVIAHRLSTIRDADSIVVLSNGQVVEQGTHDDLLALDSHYARLIRAQ 619
Query: 1817 VFADV----------DDKPKKKEAERRMSRQ-TSQRKGSVNFKTQESQVDXXXXXXXXXX 1963
+ V D+ P + E + R T+Q + + QES+
Sbjct: 620 NLSVVGREIKAGISADENPDAFDTEDEVRRVITAQTHKYRDVEGQESKPKDR-------- 671
Query: 1964 XXXXXXXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQ 2143
++ +++F +++ + +Y I A P +L FS+
Sbjct: 672 -----------------SILSSIFLVVKEQKALRLYIITSALCCTIAAATWPGQALLFSR 714
Query: 2144 IINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRI----RSK 2311
II FS D D +F+ALMF V+A L + G A ++ I R +
Sbjct: 715 IITAFS---ADTSASDVNFYALMFFVIA----LGNLVCYGIIGYIANHVSQTISYQYRLE 767
Query: 2312 VYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAF 2491
++ ++ D +FD P++S G + + L++ +++ + + I ++ +A
Sbjct: 768 LFTRMVGLDIEFFDRPENSSGALASTLSSIPTHLQELLGLNIFVIVVMFVNITASSILAI 827
Query: 2492 YYGWQMAF-LVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQAL 2668
YGW++A +V A P + ++ + + A EA+ ++RTV +L
Sbjct: 828 AYGWKLALVMVFAALPLLMGSGYFKVRLESKLHAGNEARFRESASLASEAVSSLRTVASL 887
Query: 2669 TLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVL 2848
T +T + L + I + + Y F+ SI+F A F +G ++
Sbjct: 888 TAETDFITQYSDTLSSIVMKTIKSLSVSMIAYAFSQSIEFLVMALGFWYG------SRLM 941
Query: 2849 MEPENVLRVLFAISFSFGTIGFAAS-YFPEYIKATFAAG---LIFNMLEEEPRI-DGMTS 3013
E F I G AAS F T A G +FN+ EE+ I + +
Sbjct: 942 ASGEYTSEQFFLIFMGVLFAGQAASQLFANLTSLTMAKGAANYLFNLREEKAVIRETNDN 1001
Query: 3014 SGTYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLE 3193
P + + V F+Y R + +LQGL++ + P Q +A+VGPSGCGKST+ISLLE
Sbjct: 1002 KDKCPDFDQPIGVTDVHFQYKSR-STKVLQGLSMDISPSQFVAVVGPSGCGKSTLISLLE 1060
Query: 3194 RLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQ--PGEYTH 3367
R YD G + V D++ M+P+ R +++V QEPIL++ S+RENI+ GL+ + T
Sbjct: 1061 RYYDATTGKICVGEQDIKDMSPRQFRSQMSIVQQEPILYEGSVRENILMGLEGDATDKTD 1120
Query: 3368 EQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEA 3547
E++ A +A+I +F LP+G++T G +GT SGGQ+QRIAIARALIR PK+LLLDEA
Sbjct: 1121 ERLNEAARQADILEFASSLPEGFDTPCGPRGTAFSGGQRQRIAIARALIRKPKLLLLDEA 1180
Query: 3548 TSALDTESEKQVQVALDAAAKDRTC--IVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNEL 3721
TSALDT SEK VQ AL+ K+ C I VAHRLSTI +A I V+ G+V E GTH +L
Sbjct: 1181 TSALDTHSEKLVQEALEQTRKESGCSVIAVAHRLSTIRDADIIFVLVGGKVAEVGTHEDL 1240
Query: 3722 IAKRGAYFALTQKQS 3766
A+RG Y + Q QS
Sbjct: 1241 QARRGVYADMCQAQS 1255
Score = 295 bits (755), Expect = 6e-78
Identities = 186/619 (30%), Positives = 306/619 (49%), Gaps = 26/619 (4%)
Frame = +2
Query: 2024 ANLFKILRYA-RPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSN-----PDRDQMK 2185
++L++ ++A R +W+ + GA MP ++ F + ++ D D+ K
Sbjct: 30 SDLWRAFQFADRLDWVLNVISLICSIASGAAMPVMAILFGKATGRLADFGGGSVDPDEFK 89
Query: 2186 KDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKH 2365
+ + + L F L + + ++ R T +R +V +LR + YFD
Sbjct: 90 SEVNSFVLWFTYLFVGKFVLAYVATTAITISGVRTTRVLRQRVLEKLLRTEIWYFDTA-- 147
Query: 2366 SPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMA 2545
+ G T+L T+ I I +L + +A +A W++A + + + P
Sbjct: 148 NVGSPATQLTTNVTRINQGIAEKLSLLVQGLAMFASAFVVAIAVQWKLALITLTVVPLFF 207
Query: 2546 VGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHG 2725
+ + M A A E + +IRTV A ++ + ++L H
Sbjct: 208 LIMGVFMSLDAPIEAKVTGIHSQANVFAQEVMASIRTVHAFWAHGRMSERYDNYLKEAHT 267
Query: 2726 GNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGT 2905
K+++ G+ + A AF G F ++ + V V+ ++ + +
Sbjct: 268 HGKKKSLLYGIMSSSTYFCMYSGNALAFWQG-FRMYRSGEIDSVGTVFTVVLSVLLASSS 326
Query: 2906 IGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQL-SGEVKLNKVFFRYPER 3082
IG P + AA +F + ++ +D +++ G P+ +G +++ + F YP R
Sbjct: 327 IGLLYPQIPALVNGAAAASELFQIFDKPSLLDPLSNEGQVPEACNGNIQVENISFSYPSR 386
Query: 3083 PAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPK 3262
P +L+ +++ + G+T A VG SG GKST+I LLER Y P G + +D D+ +N K
Sbjct: 387 PNTQVLKDISLDIPAGKTTAFVGASGSGKSTIIGLLERWYLPSSGRLLLDGVDISTLNVK 446
Query: 3263 HLRKHIALVSQEPILFDTSIRENIVYGLQ------PGEYTHEQIETACSKANIHKFIDEL 3424
R +ALV QEP+LF ++ EN+ G P + ++ AC + H FI L
Sbjct: 447 WFRSQMALVQQEPVLFRGTVFENVSKGFTDSQKALPLKEQRTLVQEACEASYAHDFIQNL 506
Query: 3425 PDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAA 3604
GY+T +GE+G LSGGQKQRIAIAR+++ NPKILLLDEATSALD +E+ VQ AL
Sbjct: 507 EHGYDTYLGERGGTLSGGQKQRIAIARSVVSNPKILLLDEATSALDPNAERIVQKALSRV 566
Query: 3605 AKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQ------- 3763
++ RT +V+AHRLSTI +A I+V+ NGQVVEQGTH++L+A Y L + Q
Sbjct: 567 SQQRTTLVIAHRLSTIRDADSIVVLSNGQVVEQGTHDDLLALDSHYARLIRAQNLSVVGR 626
Query: 3764 ------SSNQSGGAFDTSE 3802
S++++ AFDT +
Sbjct: 627 EIKAGISADENPDAFDTED 645
>gi|27368839|emb|CAD59577.1| MDR-like ABC transporter [Oryza sativa
(japonica cultivar-group)]
Length = 1234
Score = 672 bits (1733), Expect = 0.0
Identities = 415/1246 (33%), Positives = 646/1246 (51%), Gaps = 6/1246 (0%)
Frame = +2
Query: 44 SIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTAS 223
S+ ++++ VD L++A+G + + G L+ I +V + LG + +
Sbjct: 15 SLRGMFKFADRVDVLLMALGTLGAIGDGCSTNLLLIFASDVMNS---LG--YARAGAHGG 69
Query: 224 EKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQ 403
AA +F EV ++CL +VYL + A F++ C+ E+ R R + +++RQ
Sbjct: 70 AAAATGVDFMREVEKSCLNFVYLAFAVLAVAFMEGYCWSRTSERQVLRIRYLYLQAILRQ 129
Query: 404 EIAWYDKN--TSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
E+ ++D T+ + N + + ++E +KV L FI G A + + W L L
Sbjct: 130 EVGFFDSQEATTSEIINSISKDASLIQEVLSEKVPLFLMHSTVFISGLAFSTYFSWRLAL 189
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
+ L ++I GL +Y A + E+ L SI+TV +F ++ +R
Sbjct: 190 VSFPLVLLLIIPGLIYGKYLLYLSRQSRHEYTNANSLVEQALGSIKTVYSFTAEKRIIQR 249
Query: 758 YEDALEHGKKTGIKKSFLIGAGLASFFV-IIYASYCLAFWVGTNFVYSGRLESGTVLTVF 934
Y L+ K GI++ I GLA F + +A + W G+ V G +
Sbjct: 250 YTAVLDKTIKLGIRQG--IAKGLAVGFTGLSFAIWAFLAWYGSRLVMYHHESGGRIYAAG 307
Query: 935 FSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVN 1114
S ++G ++LG A + A AA + + I+R+PEI+A +G ++ G +
Sbjct: 308 ISFVLGGLSLGMALPELKHFTEASVAATRILDRINRVPEINADDPKGLILDQVRGELQFE 367
Query: 1115 KVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDD 1294
V F YP+R ++ +LK +L GQTVALVGSSG GKST I L+QRFY+ G + +D
Sbjct: 368 SVRFVYPSRPNMTVLKDFNLQIPAGQTVALVGSSGSGKSTAIALVQRFYDATEGTVKVDG 427
Query: 1295 IPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKT 1474
+ I++ +K++R +G+VSQ+ LF TSI++NI +G+ D + +++ A ANA +FI+
Sbjct: 428 VNIKELQLKWIRSKMGLVSQDHALFGTSIKENILFGKPDATMDELYAAAMTANAHNFIRG 487
Query: 1475 FPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALEN 1654
PE T +G+RG +SGGQKQRIAIARA+++NP ILLLDEATSALD+ESE +VQ AL+
Sbjct: 488 LPEEYETKIGERGALLSGGQKQRIAIARAVIKNPAILLLDEATSALDSESEKLVQHALDQ 547
Query: 1655 ASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVD 1834
AS GRTT+V+AH+LSTV+NAD+I V+ G + E+GTH+ LI + G Y LV Q
Sbjct: 548 ASMGRTTLVVAHKLSTVKNADQIAVVDGGTIAEIGTHDELINKGGPYSRLVKLQKMVSYI 607
Query: 1835 DKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXG 2014
D+ + +TS + S++
Sbjct: 608 DQEGGDQFRASSVARTSTSRLSMS----------------RASPMPLTPGISKETDSSVS 651
Query: 2015 AVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDG 2194
+ ++L PEW L+ G++ P +++ +I F D +M
Sbjct: 652 PPAPSFSRLLAMNAPEWRQAVIGSLSALVYGSLQPIYAITIGGMIAAFFVQDLKEMNAII 711
Query: 2195 HFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPG 2374
+AL+F L+ + L Q F E L RIR +V +L +A +FD +S G
Sbjct: 712 SRYALIFCSLSVISIVVNLLQHYNFAYMGEHLVRRIRVQVLEKILTFEAAWFDEETNSSG 771
Query: 2375 RITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQ 2554
+ +RL+ +A +K+ + R+ + + + + + W++A +++A+ P +
Sbjct: 772 SLCSRLSNEASLVKTLVADRISLLLQTASGIIIAVTMGLIVAWKLALVMIAVQPTTMICY 831
Query: 2555 ALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNI 2734
+ AK + + A+EA+ N R V + +K+ +F + P
Sbjct: 832 YAKKIVLSNVSRDLAKAQHQSTQIAIEAVYNHRMVTSFGCSSKVLQLFEHTQEEPLKRAR 891
Query: 2735 SKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGF 2914
K+ + G+T G + + F ++A F +G L + +V + F + + I
Sbjct: 892 KKSWVAGITTGLSPCLSFLSWALDFWYGGKLAQSGEI--SAGDVFKTFFVLVSTGKLIAD 949
Query: 2915 AASYFPEYIKATFAAGLIFNMLEEE---PRIDGMTSSGTYPQLSGEVKLNKVFFRYPERP 3085
A S + K A +F +L+ + P+ + ++ G ++ +V F YP RP
Sbjct: 950 AGSMTSDLAKGANAVASVFEVLDRKSISPQNSQVEKDNQKNKIQGRIEFKRVDFAYPTRP 1009
Query: 3086 AVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKH 3265
ILQ ++ VK G ++ LVG SGCGKST+I L++R YD GAV VD D+R+M+
Sbjct: 1010 QCLILQDFSLDVKAGTSIGLVGRSGCGKSTIIGLIQRFYDVDRGAVKVDGMDVREMDILW 1069
Query: 3266 LRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETR 3445
R ALVSQEP +F S+R+NI +G E ++I A AN H+FI L DGY T
Sbjct: 1070 YRGFTALVSQEPAIFSGSVRDNIAFG--KPEADEDEIVEAAKAANAHEFISSLKDGYHTD 1127
Query: 3446 VGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCI 3625
GE G QLSGGQKQRIAIARA+IRNP ILLLDEATSALD +SE+ VQ ALD RT I
Sbjct: 1128 CGEHGLQLSGGQKQRIAIARAIIRNPAILLLDEATSALDAQSEQVVQEALDRIMSGRTTI 1187
Query: 3626 VVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQ 3763
VVAHRL+TI N I + G+VVE+GT+ L++K+GA++ L Q
Sbjct: 1188 VVAHRLNTIKNVDSIAFLGEGKVVERGTYPHLMSKKGAFYNLAALQ 1233
Score = 303 bits (775), Expect = 3e-80
Identities = 199/546 (36%), Positives = 295/546 (53%), Gaps = 8/546 (1%)
Frame = +2
Query: 2171 RDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYF 2350
R+ K +F L F VLA + + +ER +RIR + +LRQ+ +F
Sbjct: 80 REVEKSCLNFVYLAFAVLAVA-----FMEGYCWSRTSERQVLRIRYLYLQAILRQEVGFF 134
Query: 2351 DMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAI 2530
D + + I ++ DA I+ + ++ GL + Y+ W++A + +
Sbjct: 135 DSQEATTSEIINSISKDASLIQEVLSEKVPLFLMHSTVFISGLAFSTYFSWRLALVSFPL 194
Query: 2531 FPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHL 2710
+ + + KY + E NA +A+ +I+TV + T + ++ + + L
Sbjct: 195 VLLLIIPGLIYGKYLLYLSRQSRHEYTNANSLVEQALGSIKTVYSFTAEKRIIQRYTAVL 254
Query: 2711 DAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFA-I 2887
D I + I +GL GF + F +A +G L V+ E+ R+ A I
Sbjct: 255 DKTIKLGIRQGIAKGLAVGFTG-LSFAIWAFLAWYGSRL-----VMYHHESGGRIYAAGI 308
Query: 2888 SFSFG--TIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTY-PQLSGEVKLNK 3058
SF G ++G A + +A+ AA I + + P I+ G Q+ GE++
Sbjct: 309 SFVLGGLSLGMALPELKHFTEASVAATRILDRINRVPEINADDPKGLILDQVRGELQFES 368
Query: 3059 VFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNN 3238
V F YP RP + +L+ N+ + GQT+ALVG SG GKST I+L++R YD EG V VD
Sbjct: 369 VRFVYPSRPNMTVLKDFNLQIPAGQTVALVGSSGSGKSTAIALVQRFYDATEGTVKVDGV 428
Query: 3239 DLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFID 3418
+++++ K +R + LVSQ+ LF TSI+ENI++G + T +++ A AN H FI
Sbjct: 429 NIKELQLKWIRSKMGLVSQDHALFGTSIKENILFGKP--DATMDELYAAAMTANAHNFIR 486
Query: 3419 ELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALD 3598
LP+ YET++GE+G LSGGQKQRIAIARA+I+NP ILLLDEATSALD+ESEK VQ ALD
Sbjct: 487 GLPEEYETKIGERGALLSGGQKQRIAIARAVIKNPAILLLDEATSALDSESEKLVQHALD 546
Query: 3599 AAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSS--- 3769
A+ RT +VVAH+LST+ NA I VV G + E GTH+ELI K G Y L + Q
Sbjct: 547 QASMGRTTLVVAHKLSTVKNADQIAVVDGGTIAEIGTHDELINKGGPYSRLVKLQKMVSY 606
Query: 3770 -NQSGG 3784
+Q GG
Sbjct: 607 IDQEGG 612
>gi|37806003|dbj|BAC99416.1| putative MDR-like ABC transporter [Oryza
sativa (japonica cultivar-group)]
gi|37806247|dbj|BAC99764.1| putative MDR-like ABC transporter [Oryza
sativa (japonica cultivar-group)]
Length = 1261
Score = 669 bits (1725), Expect = 0.0
Identities = 427/1254 (34%), Positives = 645/1254 (51%), Gaps = 19/1254 (1%)
Frame = +2
Query: 65 YTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARA 244
Y VD L++A+G + S G+ P+ +++G LD T
Sbjct: 47 YADAVDWLLMALGTVGSIIHGMAFPVGYLLLGKA-----------LDAYGTNINDQEGMV 95
Query: 245 EFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYDK 424
++V+ Y+ AG ++ SC++ E+ R R F SV+ QE+ +D
Sbjct: 96 HALYKVVPFVW---YMAAATLPAGMVEISCWIYSSERQLARMRLAFLRSVLNQEVGAFDT 152
Query: 425 N-TSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPF 601
+ T+ + + +++ +++ G+K+G + F G +AF W + L+ + P
Sbjct: 153 DLTTAKIITGVTNHMSVIQDAIGEKLGHFVASFSTFFAGIIIAFASCWEVALLSFLVIPL 212
Query: 602 MMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHG 781
+++ G + A I E+ L+ I+TV +F G++ + + +++
Sbjct: 213 ILVIGATYTKQMNGISLSRNAIVSEATSIVEQTLSHIKTVFSFVGEKRAMRSFVRCMDNQ 272
Query: 782 KKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMA 961
K K++ + G GL F + + S+ L W+G V S + G + S++ G+++
Sbjct: 273 YKLSKKEAVIKGIGLGLFQAVTFCSWALMVWIGAVAVTSRKATGGGTIAAIMSILFGAIS 332
Query: 962 LGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTR 1141
+ A T A A +++VI R P I +Y G K+ G I +V F YP+R
Sbjct: 333 ITYAAPDLQTFNQAKAAGKEVFKVIKRKPSI-SYEKHGSVLGKVHGEIKFRRVHFAYPSR 391
Query: 1142 ADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIK 1321
D IL+G SL G+ VALVGSSGCGKST+I LLQRFY+P +G ILID I+ +++
Sbjct: 392 QDKPILQGFSLSIPAGKVVALVGSSGCGKSTVISLLQRFYDPTSGSILIDGHSIKKLDLE 451
Query: 1322 YLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEGLNTLV 1501
LR+ + VSQEP+LF+ +I+ N+R G+ D +D++I +A + AN FI P T V
Sbjct: 452 SLRRNIASVSQEPSLFSGTIKDNLRIGKMDANDDEITKAARTANVHSFISKLPNEYLTEV 511
Query: 1502 GDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIV 1681
G+RGVQ+SGGQKQRIAIARA++++P ILLLDEATSALD+ESE +VQ ALE A GRT I+
Sbjct: 512 GERGVQLSGGQKQRIAIARAMLKDPPILLLDEATSALDSESEKLVQDALEKAMSGRTVIL 571
Query: 1682 IAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVF--------ADVDD 1837
IAHR+ST+ NAD I+V++ G+V + GTH+ LIE+ Y + Q A D
Sbjct: 572 IAHRMSTIVNADTIVVVENGKVAQTGTHQELIEKSTFYSNVCSMQNIEKEAGTRVASSSD 631
Query: 1838 KPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXGA 2017
+ E + RQ S ++G N Q G
Sbjct: 632 NVIEDEIDEVYDRQLSPKQGQQNKLEQ---------LNSKQPKQEVRKEIHPFFRLWYGL 682
Query: 2018 VKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGH 2197
K ++ KIL I G P F F I + + D K+
Sbjct: 683 QKDDIAKIL-----------LGSSSAAISGISKPLFGYFIMTIGVAYYDLD---AKRKVS 728
Query: 2198 FWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGR 2377
++L+F + S +FQ ++GV E+ +R ++ +VLR + +F+ PK+ G
Sbjct: 729 KYSLIFFTAGVITLASNIFQHYIYGVVGEKAMKILREAIFSSVLRNELGWFEKPKNGVGF 788
Query: 2378 ITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQA 2557
+T+R+ +D +K+ I R+ I I+S+ ++ Y W+M + A+ P +G
Sbjct: 789 LTSRIVSDTSTVKTIISDRMAVIVQCISSILIATVVSMYVNWRMGLVSWAVMPCHFIGGL 848
Query: 2558 LMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNIS 2737
+ K G A + A EA NIRTV + + ++ L P
Sbjct: 849 IQAKAAKGFYGDSAIAHQELVSLASEAASNIRTVASFVYEDEIIKKAELSLQEPMRVTKI 908
Query: 2738 KAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFA 2917
+++ G+ G + + +A A + L+ K EN +R S + +I
Sbjct: 909 ESMKYGVVQGISLCLWNIAHAVALWYTTVLVQRKQASF--ENSIRSYQIFSLTVPSITEL 966
Query: 2918 ASYFPEYIKATFAAGLIFNMLEEEPRI-DGMTSSGTYPQLSGEVKLNKVFFRYPERPAVP 3094
+ P + A F ML+ + +I + + L G + V F YP RP V
Sbjct: 967 WTLIPMVMSAIAVLNPAFEMLDRDTQIVPDRPENPSDGWLMGRTEFQDVSFNYPSRPEVT 1026
Query: 3095 ILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRK 3274
IL G ++ ++PGQ +ALVGPSG GKS+V++LL R YDP G V +DN +++ N + LRK
Sbjct: 1027 ILDGFSLVIEPGQRVALVGPSGAGKSSVLALLLRFYDPQRGRVLIDNKNIKDYNLRWLRK 1086
Query: 3275 HIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGE 3454
I LV QEPILF++SIR+NI YG + E + +I A +ANIH+FI LP GY+T VGE
Sbjct: 1087 QIGLVQQEPILFNSSIRDNISYGSE--ETSETEIIQAAMEANIHEFISSLPKGYDTVVGE 1144
Query: 3455 KGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAA-KDR----- 3616
KG+QLSGGQKQRIAIAR L++ P ILLLDEATSALD ESE+ V +L A KDR
Sbjct: 1145 KGSQLSGGQKQRIAIARTLLKRPVILLLDEATSALDGESERVVMSSLGAKDWKDRNEGSS 1204
Query: 3617 --TCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELI-AKRGAYFALTQKQSS 3769
T I VAHRLST++N+ I+V++ G+VVE G H+ LI A G Y L QS+
Sbjct: 1205 KITSITVAHRLSTVINSDTIVVMERGKVVELGNHHTLITADDGVYSRLFHLQSN 1258
Score = 320 bits (821), Expect = 1e-85
Identities = 197/580 (33%), Positives = 312/580 (52%), Gaps = 5/580 (0%)
Frame = +2
Query: 2060 EWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHFWALMFLV-----L 2224
+W+ +I G P L + ++ + DQ +G AL +V +
Sbjct: 52 DWLLMALGTVGSIIHGMAFPVGYLLLGKALDAYGTNINDQ---EGMVHALYKVVPFVWYM 108
Query: 2225 AAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDA 2404
AA + + + S + ++ER R+R R+VL Q+ FD + +I T +
Sbjct: 109 AAATLPAGMVEISCWIYSSERQLARMRLAFLRSVLNQEVGAFDTDL-TTAKIITGVTNHM 167
Query: 2405 PNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGS 2584
I+ AI +LG + ++ G+ IAF W++A L + P + V A K G
Sbjct: 168 SVIQDAIGEKLGHFVASFSTFFAGIIIAFASCWEVALLSFLVIPLILVIGATYTKQMNGI 227
Query: 2585 ATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTY 2764
+ S + A + + +I+TV + + + F +D + + +A+I+G+
Sbjct: 228 SLSRNAIVSEATSIVEQTLSHIKTVFSFVGEKRAMRSFVRCMDNQYKLSKKEAVIKGIGL 287
Query: 2765 GFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIK 2944
G ++ F ++A G + + + + +I F +I +AA + +
Sbjct: 288 GLFQAVTFCSWALMVWIGAVAVTSRKAT--GGGTIAAIMSILFGAISITYAAPDLQTFNQ 345
Query: 2945 ATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVK 3124
A A +F +++ +P I ++ GE+K +V F YP R PILQG ++ +
Sbjct: 346 AKAAGKEVFKVIKRKPSISYEKHGSVLGKVHGEIKFRRVHFAYPSRQDKPILQGFSLSIP 405
Query: 3125 PGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPI 3304
G+ +ALVG SGCGKSTVISLL+R YDP G++ +D + +++++ + LR++IA VSQEP
Sbjct: 406 AGKVVALVGSSGCGKSTVISLLQRFYDPTSGSILIDGHSIKKLDLESLRRNIASVSQEPS 465
Query: 3305 LFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQK 3484
LF +I++N+ G + ++I A AN+H FI +LP+ Y T VGE+G QLSGGQK
Sbjct: 466 LFSGTIKDNLRIGKM--DANDDEITKAARTANVHSFISKLPNEYLTEVGERGVQLSGGQK 523
Query: 3485 QRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAG 3664
QRIAIARA++++P ILLLDEATSALD+ESEK VQ AL+ A RT I++AHR+STIVNA
Sbjct: 524 QRIAIARAMLKDPPILLLDEATSALDSESEKLVQDALEKAMSGRTVILIAHRMSTIVNAD 583
Query: 3665 CIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSSNQSGG 3784
I+VV+NG+V + GTH ELI K Y + Q+ + G
Sbjct: 584 TIVVVENGKVAQTGTHQELIEKSTFYSNVCSMQNIEKEAG 623
Score = 303 bits (777), Expect = 2e-80
Identities = 196/603 (32%), Positives = 312/603 (51%), Gaps = 14/603 (2%)
Frame = +2
Query: 50 FQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEK 229
F+L+ D + +G + +G+ PL + +T+G + D ++
Sbjct: 676 FRLWYGLQKDDIAKILLGSSSAAISGISKPLFGYFI-------MTIGVAYYDLDA----- 723
Query: 230 AAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEI 409
+V + L + G A+ Q + V+ EK R F SV+R E+
Sbjct: 724 -------KRKVSKYSLIFFTAGVITLASNIFQHYIYGVVGEKAMKILREAIFSSVLRNEL 776
Query: 410 AWYDK--NTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIM 583
W++K N G L++++ + V+ D++ + Q ++ + V+ +W + L+
Sbjct: 777 GWFEKPKNGVGFLTSRIVSDTSTVKTIISDRMAVIVQCISSILIATVVSMYVNWRMGLVS 836
Query: 584 MSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYE 763
++ P I GL + +A E ++IRTV +F ++ K+ E
Sbjct: 837 WAVMPCHFIGGLIQAKAAKGFYGDSAIAHQELVSLASEAASNIRTVASFVYEDEIIKKAE 896
Query: 764 DALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSV 943
+L+ + +S G + ++ +A W T V + + + S
Sbjct: 897 LSLQEPMRVTKIESMKYGVVQGISLCLWNIAHAVALWYTTVLV---QRKQASFENSIRSY 953
Query: 944 MMGSMALGQAGQQFATIGTALGAAASL---YEVIDRIPEIDAYSTEGQTPSKISGRISVN 1114
+ S+ + + + I + A A L +E++DR +I E + + GR
Sbjct: 954 QIFSLTVPSITELWTLIPMVMSAIAVLNPAFEMLDRDTQIVPDRPENPSDGWLMGRTEFQ 1013
Query: 1115 KVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDD 1294
V F YP+R +V IL G SL +PGQ VALVG SG GKS+++ LL RFY+P G++LID+
Sbjct: 1014 DVSFNYPSRPEVTILDGFSLVIEPGQRVALVGPSGAGKSSVLALLLRFYDPQRGRVLIDN 1073
Query: 1295 IPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKT 1474
I+D+N+++LR+ +G+V QEP LFN+SI NI YG + S+ +I +A EAN +FI +
Sbjct: 1074 KNIKDYNLRWLRKQIGLVQQEPILFNSSIRDNISYGSEETSETEIIQAAMEANIHEFISS 1133
Query: 1475 FPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSAL-- 1648
P+G +T+VG++G Q+SGGQKQRIAIAR L++ P ILLLDEATSALD ESE +V S+L
Sbjct: 1134 LPKGYDTVVGEKGSQLSGGQKQRIAIARTLLKRPVILLLDEATSALDGESERVVMSSLGA 1193
Query: 1649 ------ENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLI-EQKGLYHELV 1807
S T+I +AHRLSTV N+D I+VM+ G+V+E+G H TLI G+Y L
Sbjct: 1194 KDWKDRNEGSSKITSITVAHRLSTVINSDTIVVMERGKVVELGNHHTLITADDGVYSRLF 1253
Query: 1808 HAQ 1816
H Q
Sbjct: 1254 HLQ 1256
>gi|34910738|ref|NP_916716.1| putative P-glycoprotein [Oryza sativa
(japonica cultivar-group)]
gi|20160550|dbj|BAB89499.1| putative P-glycoprotein [Oryza sativa
(japonica cultivar-group)]
Length = 1203
Score = 667 bits (1722), Expect = 0.0
Identities = 414/1246 (33%), Positives = 643/1246 (51%), Gaps = 6/1246 (0%)
Frame = +2
Query: 44 SIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTAS 223
S+ ++++ VD L++A+G + + G L+ I +V + LG + +
Sbjct: 15 SLRGMFKFADRVDVLLMALGTLGAIGDGCSTNLLLIFASDVMNS---LG--YARAGAHGG 69
Query: 224 EKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQ 403
AA +F EV ++CL +VYL + A F++ C+ E+ R R + +++RQ
Sbjct: 70 AAAATGVDFMREVEKSCLNFVYLAFAVLAVAFMEGYCWSRTSERQVLRIRYLYLQAILRQ 129
Query: 404 EIAWYDKN--TSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
E+ ++D T+ + N + + ++E +KV L FI G A + + W L L
Sbjct: 130 EVGFFDSQEATTSEIINSISKDASLIQEVLSEKVPLFLMHSTVFISGLAFSTYFSWRLAL 189
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
+ L ++I GL +Y A + E+ L SI+TV +F ++ +R
Sbjct: 190 VSFPLVLLLIIPGLIYGKYLLYLSRQSRHEYTNANSLVEQALGSIKTVYSFTAEKRIIQR 249
Query: 758 YEDALEHGKKTGIKKSFLIGAGLASFFV-IIYASYCLAFWVGTNFVYSGRLESGTVLTVF 934
Y L+ K GI++ I GLA F + +A + W G+ V G +
Sbjct: 250 YTAVLDKTIKLGIRQG--IAKGLAVGFTGLSFAIWAFLAWYGSRLVMYHHESGGRIYAAG 307
Query: 935 FSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVN 1114
S ++G ++LG A + A AA + + I+R+PEI+A +G ++ G +
Sbjct: 308 ISFVLGGLSLGMALPELKHFTEASVAATRILDRINRVPEINADDPKGLILDQVRGELQFE 367
Query: 1115 KVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDD 1294
V F YP+R ++ +LK +L GQTVALVGSSG GKST I L+QRFY+ G + +D
Sbjct: 368 SVRFVYPSRPNMTVLKDFNLQIPAGQTVALVGSSGSGKSTAIALVQRFYDATEGTVKVDG 427
Query: 1295 IPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKT 1474
+ I++ +K++R +G+VSQ+ LF TSI++NI +G+ D + +++ A ANA +FI+
Sbjct: 428 VNIKELQLKWIRSKMGLVSQDHALFGTSIKENILFGKPDATMDELYAAAMTANAHNFIRG 487
Query: 1475 FPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALEN 1654
PE T +G+RG +SGGQKQRIAIARA+++NP ILLLDEATSALD+ESE +VQ AL+
Sbjct: 488 LPEEYETKIGERGALLSGGQKQRIAIARAVIKNPAILLLDEATSALDSESEKLVQHALDQ 547
Query: 1655 ASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVD 1834
AS GRTT+V+AH+LSTV+NAD+I V+ G + E+GTH+ LI + G Y LV Q
Sbjct: 548 ASMGRTTLVVAHKLSTVKNADQIAVVDGGTIAEIGTHDELINKGGPYSRLVKLQKMGLFS 607
Query: 1835 DKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXG 2014
K + + ++ S+
Sbjct: 608 GKDQYQPSQYVQSKS--------------------------------------------- 622
Query: 2015 AVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDG 2194
A ++L PEW L+ G++ P +++ +I F D +M
Sbjct: 623 --NATYTRLLAMNAPEWRQAVIGSLSALVYGSLQPIYAITIGGMIAAFFVQDLKEMNAII 680
Query: 2195 HFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPG 2374
+AL+F L+ + L Q F E L RIR +V +L +A +FD +S G
Sbjct: 681 SRYALIFCSLSVISIVVNLLQHYNFAYMGEHLVRRIRVQVLEKILTFEAAWFDEETNSSG 740
Query: 2375 RITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQ 2554
+ +RL+ +A +K+ + R+ + + + + + W++A +++A+ P +
Sbjct: 741 SLCSRLSNEASLVKTLVADRISLLLQTASGIIIAVTMGLIVAWKLALVMIAVQPTTMICY 800
Query: 2555 ALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNI 2734
+ AK + + A+EA+ N R V + +K+ +F + P
Sbjct: 801 YAKKIVLSNVSRDLAKAQHQSTQIAIEAVYNHRMVTSFGCSSKVLQLFEHTQEEPLKRAR 860
Query: 2735 SKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGF 2914
K+ + G+T G + + F ++A F +G L + +V + F + + I
Sbjct: 861 KKSWVAGITTGLSPCLSFLSWALDFWYGGKLAQSGEI--SAGDVFKTFFVLVSTGKLIAD 918
Query: 2915 AASYFPEYIKATFAAGLIFNMLEEE---PRIDGMTSSGTYPQLSGEVKLNKVFFRYPERP 3085
A S + K A +F +L+ + P+ + ++ G ++ +V F YP RP
Sbjct: 919 AGSMTSDLAKGANAVASVFEVLDRKSISPQNSQVEKDNQKNKIQGRIEFKRVDFAYPTRP 978
Query: 3086 AVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKH 3265
ILQ ++ VK G ++ LVG SGCGKST+I L++R YD GAV VD D+R+M+
Sbjct: 979 QCLILQDFSLDVKAGTSIGLVGRSGCGKSTIIGLIQRFYDVDRGAVKVDGMDVREMDILW 1038
Query: 3266 LRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETR 3445
R ALVSQEP +F S+R+NI +G E ++I A AN H+FI L DGY T
Sbjct: 1039 YRGFTALVSQEPAIFSGSVRDNIAFG--KPEADEDEIVEAAKAANAHEFISSLKDGYHTD 1096
Query: 3446 VGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCI 3625
GE G QLSGGQKQRIAIARA+IRNP ILLLDEATSALD +SE+ VQ ALD RT I
Sbjct: 1097 CGEHGLQLSGGQKQRIAIARAIIRNPAILLLDEATSALDAQSEQVVQEALDRIMSGRTTI 1156
Query: 3626 VVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQ 3763
VVAHRL+TI N I + G+VVE+GT+ L++K+GA++ L Q
Sbjct: 1157 VVAHRLNTIKNVDSIAFLGEGKVVERGTYPHLMSKKGAFYNLAALQ 1202
Score = 302 bits (774), Expect = 4e-80
Identities = 197/542 (36%), Positives = 292/542 (53%), Gaps = 4/542 (0%)
Frame = +2
Query: 2171 RDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYF 2350
R+ K +F L F VLA + + +ER +RIR + +LRQ+ +F
Sbjct: 80 REVEKSCLNFVYLAFAVLAVA-----FMEGYCWSRTSERQVLRIRYLYLQAILRQEVGFF 134
Query: 2351 DMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAI 2530
D + + I ++ DA I+ + ++ GL + Y+ W++A + +
Sbjct: 135 DSQEATTSEIINSISKDASLIQEVLSEKVPLFLMHSTVFISGLAFSTYFSWRLALVSFPL 194
Query: 2531 FPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHL 2710
+ + + KY + E NA +A+ +I+TV + T + ++ + + L
Sbjct: 195 VLLLIIPGLIYGKYLLYLSRQSRHEYTNANSLVEQALGSIKTVYSFTAEKRIIQRYTAVL 254
Query: 2711 DAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFA-I 2887
D I + I +GL GF + F +A +G L V+ E+ R+ A I
Sbjct: 255 DKTIKLGIRQGIAKGLAVGFTG-LSFAIWAFLAWYGSRL-----VMYHHESGGRIYAAGI 308
Query: 2888 SFSFG--TIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTY-PQLSGEVKLNK 3058
SF G ++G A + +A+ AA I + + P I+ G Q+ GE++
Sbjct: 309 SFVLGGLSLGMALPELKHFTEASVAATRILDRINRVPEINADDPKGLILDQVRGELQFES 368
Query: 3059 VFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNN 3238
V F YP RP + +L+ N+ + GQT+ALVG SG GKST I+L++R YD EG V VD
Sbjct: 369 VRFVYPSRPNMTVLKDFNLQIPAGQTVALVGSSGSGKSTAIALVQRFYDATEGTVKVDGV 428
Query: 3239 DLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFID 3418
+++++ K +R + LVSQ+ LF TSI+ENI++G + T +++ A AN H FI
Sbjct: 429 NIKELQLKWIRSKMGLVSQDHALFGTSIKENILFGKP--DATMDELYAAAMTANAHNFIR 486
Query: 3419 ELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALD 3598
LP+ YET++GE+G LSGGQKQRIAIARA+I+NP ILLLDEATSALD+ESEK VQ ALD
Sbjct: 487 GLPEEYETKIGERGALLSGGQKQRIAIARAVIKNPAILLLDEATSALDSESEKLVQHALD 546
Query: 3599 AAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSSNQS 3778
A+ RT +VVAH+LST+ NA I VV G + E GTH+ELI K G Y L + Q
Sbjct: 547 QASMGRTTLVVAHKLSTVKNADQIAVVDGGTIAEIGTHDELINKGGPYSRLVKLQKMGLF 606
Query: 3779 GG 3784
G
Sbjct: 607 SG 608
>gi|50732439|ref|XP_418636.1| PREDICTED: similar to Multidrug
resistance protein 3 (P-glycoprotein 3) [Gallus gallus]
Length = 1183
Score = 664 bits (1714), Expect = 0.0
Identities = 363/759 (47%), Positives = 478/759 (62%), Gaps = 1/759 (0%)
Frame = +2
Query: 1493 TLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRT 1672
T+VG+RG QMSGGQKQRIAIARALVRNPKILLLDEATSALD ESES+VQ+AL+ +GRT
Sbjct: 429 TVVGERGAQMSGGQKQRIAIARALVRNPKILLLDEATSALDTESESVVQAALDKIRKGRT 488
Query: 1673 TIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVDDKPKKK 1852
+VIAHRLSTVRNAD I + G + E GTH+ L+EQKG+Y++LV+ Q D ++
Sbjct: 489 ILVIAHRLSTVRNADLIAAFENGVITEQGTHDELMEQKGVYYKLVNMQASETEDQLQEEG 548
Query: 1853 EAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXGAVKANL 2032
A +S + ++N Q ++
Sbjct: 549 NA-------SSVSEEALNGSVLTGQKRQSTRKSIKRVRIQNDELDVKADQLDKNMPPSSF 601
Query: 2033 FKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHFWALM 2212
FKI++ + EW Y +I GA+ P FS+ S +I +F + +++ +AL+
Sbjct: 602 FKIMKLNKTEWPYFVVGTLCAIINGALQPIFSVMISDVIGMFVEKGKAAIRETNSTYALL 661
Query: 2213 FLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRL 2392
FL + + Q FG A E LTMR+RS +R +LRQ+ ++FD PK+S G + TRL
Sbjct: 662 FLGFGLISFVTFFLQGFTFGKAGEILTMRLRSMAFRAILRQEISWFDEPKNSTGELITRL 721
Query: 2393 ATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKY 2572
A DA +K A RL + IA++G G+ ++ YGWQ+ L++AI P +A+ + MK
Sbjct: 722 ANDASQVKGATGSRLALVAQNIANLGTGIVLSLIYGWQLTLLLLAIVPIIAITGMIQMKM 781
Query: 2573 HGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIR 2752
G A D KE+E GK A EAIENIRTV ALT + K ++ +L + +I KA I
Sbjct: 782 LAGHAKKDKKELETLGKVASEAIENIRTVVALTQERKFEYMYGQNLQVSYRNSIKKAHIF 841
Query: 2753 GLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFP 2932
G T+ F +I +FTYA FRFG +L+ KN M ++VL V AI F +G + S+ P
Sbjct: 842 GFTFAFTQAIMYFTYAGCFRFGAYLV--KNGHMRFKDVLLVFSAIVFGAMALGQSTSFTP 899
Query: 2933 EYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQL-SGEVKLNKVFFRYPERPAVPILQGL 3109
+Y KA +A +F + E P ID + G P++ G + V F+YP RP V +LQGL
Sbjct: 900 DYAKAKMSAAHLFLLFERVPLIDSYSEEGEKPKMFGGNITFKDVAFKYPTRPEVKVLQGL 959
Query: 3110 NVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALV 3289
N+ V+ GQTLALVG SGCGKSTV+ LLER YDPL G V +D + + +N + LR I +V
Sbjct: 960 NIEVEKGQTLALVGSSGCGKSTVVQLLERFYDPLSGEVLLDGRNTKTLNIQWLRAQIGIV 1019
Query: 3290 SQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQL 3469
SQEPILFD +I ENI YG E +HE+I +A ANIH FI+ LP Y TRVG+KG QL
Sbjct: 1020 SQEPILFDCTIAENIAYGDNSREVSHEEIVSAAKAANIHSFIESLPKKYNTRVGDKGAQL 1079
Query: 3470 SGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLST 3649
SGGQKQRIAIARALIR P+ILLLDEATSALDTESEK VQ ALD A + RTCIV+AHRLST
Sbjct: 1080 SGGQKQRIAIARALIRQPRILLLDEATSALDTESEKIVQEALDKAREGRTCIVIAHRLST 1139
Query: 3650 IVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQS 3766
I NA I V++NG+V+EQGTH +L+A++G Y++L QS
Sbjct: 1140 IQNADKIAVIQNGKVIEQGTHQQLLAEKGFYYSLVNVQS 1178
Score = 421 bits (1081), Expect = e-116
Identities = 241/597 (40%), Positives = 355/597 (59%), Gaps = 6/597 (1%)
Frame = +2
Query: 44 SIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTAS 223
S F++ + T + VG + + G P+ S+++ +V FV G
Sbjct: 600 SFFKIMKLNKT-EWPYFVVGTLCAIINGALQPIFSVMISDVIGMFVEKG----------- 647
Query: 224 EKAAARAEFSHEVIQNCLKYVYLGCGI--FAAGFLQASCFMVICEKLSNRFRRQFFHSVM 397
KAA R S + ++LG G+ F FLQ F E L+ R R F +++
Sbjct: 648 -KAAIRETNSTYAL------LFLGFGLISFVTFFLQGFTFGKAGEILTMRLRSMAFRAIL 700
Query: 398 RQEIAWYD--KNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLL 571
RQEI+W+D KN++G L +L ++ +V+ TG ++ L Q +A G ++ Y W L
Sbjct: 701 RQEISWFDEPKNSTGELITRLANDASQVKGATGSRLALVAQNIANLGTGIVLSLIYGWQL 760
Query: 572 TLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYEC 751
TL+++++ P + I G+ + G +A E + +IRTV+A +
Sbjct: 761 TLLLLAIVPIIAITGMIQMKMLAGHAKKDKKELETLGKVASEAIENIRTVVALTQERKFE 820
Query: 752 KRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTV 931
Y L+ + IKK+ + G A I+Y +Y F G V +G + VL V
Sbjct: 821 YMYGQNLQVSYRNSIKKAHIFGFTFAFTQAIMYFTYAGCFRFGAYLVKNGHMRFKDVLLV 880
Query: 932 FFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISV 1111
F +++ G+MALGQ+ A +AA L+ + +R+P ID+YS EG+ P G I+
Sbjct: 881 FSAIVFGAMALGQSTSFTPDYAKAKMSAAHLFLLFERVPLIDSYSEEGEKPKMFGGNITF 940
Query: 1112 NKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILID 1291
V F YPTR +VK+L+G++++ + GQT+ALVGSSGCGKST++QLL+RFY+P +G++L+D
Sbjct: 941 KDVAFKYPTRPEVKVLQGLNIEVEKGQTLALVGSSGCGKSTVVQLLERFYDPLSGEVLLD 1000
Query: 1292 DIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRS--DVSDEDIARALKEANAADF 1465
+ NI++LR +G+VSQEP LF+ +I +NI YG + +VS E+I A K AN F
Sbjct: 1001 GRNTKTLNIQWLRAQIGIVSQEPILFDCTIAENIAYGDNSREVSHEEIVSAAKAANIHSF 1060
Query: 1466 IKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSA 1645
I++ P+ NT VGD+G Q+SGGQKQRIAIARAL+R P+ILLLDEATSALD ESE IVQ A
Sbjct: 1061 IESLPKKYNTRVGDKGAQLSGGQKQRIAIARALIRQPRILLLDEATSALDTESEKIVQEA 1120
Query: 1646 LENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQ 1816
L+ A GRT IVIAHRLST++NADKI V++ G+V+E GTH+ L+ +KG Y+ LV+ Q
Sbjct: 1121 LDKAREGRTCIVIAHRLSTIQNADKIAVIQNGKVIEQGTHQQLLAEKGFYYSLVNVQ 1177
Score = 299 bits (766), Expect = 3e-79
Identities = 170/519 (32%), Positives = 258/519 (48%), Gaps = 31/519 (5%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTA 220
+S ++RY+ D+L++ +G ++ G LPLM I+ G+++ F+ N +
Sbjct: 2 VSPLAVFRYSDRQDKLLMVLGTTMAVLHGASLPLMMIVFGDMTDTFIASENTTYPANFSL 61
Query: 221 SEKAAAR-----------AEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNR 367
+ E E+ + Y +G G+ A ++Q S + + + R
Sbjct: 62 LNSTSVNFSMEFFSYLILGELEEEMTRYAYYYSGIGAGVLFAAYIQVSFWTLAAGRQIKR 121
Query: 368 FRRQFFHSVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAV 547
R++FFH+VMRQEI W+D N L+ ++ D++ ++ EG G+K+ + FQ +A F GF V
Sbjct: 122 IRQEFFHAVMRQEIGWFDVNDVCELNTRIVDDISKINEGIGEKIAMFFQAVATFFTGFIV 181
Query: 548 AFTYDWLLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIA 727
FT W LTL++++LSP + YA AG +AEEVL ++RTV+A
Sbjct: 182 GFTKGWKLTLVILALSPVLGFSSALWAKIISTFTNKELTAYAKAGAVAEEVLAAVRTVVA 241
Query: 728 FNGQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRL 907
F GQ E +RY+ LE K+ GI+K+ + F +IY SY LAFW GT V S
Sbjct: 242 FGGQRKETERYQKNLEDAKRMGIQKAISANISMGVSFFLIYGSYALAFWYGTILVLSEDY 301
Query: 908 ESGTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPS 1087
G V TVFFS+++G+ ++GQA A GAA +++ +ID P+ID+ S G
Sbjct: 302 TIGKVFTVFFSILVGAFSVGQAAPSMEAFANARGAAYAIFNIIDNEPQIDSSSNAGYKLD 361
Query: 1088 KISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNP 1267
+ G + V F+YP R D+KILKG++L GQTVALVG GCGKST +QL+ + Y+P
Sbjct: 362 HVKGNLEFQNVYFSYPARPDIKILKGLNLKVNCGQTVALVGGGGCGKSTTVQLILKCYDP 421
Query: 1268 DAG--------------------QILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQ 1387
G +I I + + I L + + E +
Sbjct: 422 KEGTKFETVVGERGAQMSGGQKQRIAIARALVRNPKILLLDEATSALDTESESVVQAALD 481
Query: 1388 NIRYGRSDVSDEDIARALKEANAADFIKTFPEGLNTLVG 1504
IR GR+ + IA L AD I F G+ T G
Sbjct: 482 KIRKGRTILV---IAHRLSTVRNADLIAAFENGVITEQG 517
Score = 169 bits (427), Expect = 6e-40
Identities = 105/332 (31%), Positives = 168/332 (49%), Gaps = 5/332 (1%)
Frame = +2
Query: 2237 GTSMLF----QCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDA 2404
G +LF Q S + +AA R RIR + + V+RQ+ +FD+ + + TR+ D
Sbjct: 97 GAGVLFAAYIQVSFWTLAAGRQIKRIRQEFFHAVMRQEIGWFDV--NDVCELNTRIVDDI 154
Query: 2405 PNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGS 2584
I I ++ F A+A+ G + F GW++ +++A+ P + AL K
Sbjct: 155 SKINEGIGEKIAMFFQAVATFFTGFIVGFTKGWKLTLVILALSPVLGFSSALWAKIISTF 214
Query: 2585 ATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTY 2764
+ AG A E + +RTV A Q K + +L+ I KAI ++
Sbjct: 215 TNKELTAYAKAGAVAEEVLAAVRTVVAFGGQRKETERYQKNLEDAKRMGIQKAISANISM 274
Query: 2765 GFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIK 2944
G + + + +YA AF +G L+ ++ + V V F+I ++G AA +
Sbjct: 275 GVSFFLIYGSYALAFWYGTILVLSEDYTIG--KVFTVFFSILVGAFSVGQAAPSMEAFAN 332
Query: 2945 ATFAAGLIFNMLEEEPRIDGMTSSG-TYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHV 3121
A AA IFN+++ EP+ID +++G + G ++ V+F YP RP + IL+GLN+ V
Sbjct: 333 ARGAAYAIFNIIDNEPQIDSSSNAGYKLDHVKGNLEFQNVYFSYPARPDIKILKGLNLKV 392
Query: 3122 KPGQTLALVGPSGCGKSTVISLLERLYDPLEG 3217
GQT+ALVG GCGKST + L+ + YDP EG
Sbjct: 393 NCGQTVALVGGGGCGKSTTVQLILKCYDPKEG 424
Score = 147 bits (370), Expect = 3e-33
Identities = 77/129 (59%), Positives = 93/129 (71%), Gaps = 6/129 (4%)
Frame = +2
Query: 3434 YETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKD 3613
+ET VGE+G Q+SGGQKQRIAIARAL+RNPKILLLDEATSALDTESE VQ ALD K
Sbjct: 427 FETVVGERGAQMSGGQKQRIAIARALVRNPKILLLDEATSALDTESESVVQAALDKIRKG 486
Query: 3614 RTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSS------NQ 3775
RT +V+AHRLST+ NA I +NG + EQGTH+EL+ ++G Y+ L Q+S +
Sbjct: 487 RTILVIAHRLSTVRNADLIAAFENGVITEQGTHDELMEQKGVYYKLVNMQASETEDQLQE 546
Query: 3776 SGGAFDTSE 3802
G A SE
Sbjct: 547 EGNASSVSE 555
>gi|27368843|emb|CAD59579.1| MDR-like ABC transporter [Oryza sativa
(japonica cultivar-group)]
Length = 1242
Score = 651 bits (1680), Expect = 0.0
Identities = 423/1254 (33%), Positives = 637/1254 (50%), Gaps = 19/1254 (1%)
Frame = +2
Query: 65 YTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARA 244
Y VD L++A+G + S G+ P+ +++G LD T
Sbjct: 47 YADAVDWLLMALGTVGSIIHGMAFPVGYLLLGKA-----------LDAYGTNINDQEGMV 95
Query: 245 EFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYDK 424
++V+ Y+ AG ++ SC++ E+ R R F SV+ QE+ +D
Sbjct: 96 HALYKVVPFVW---YMAAATLPAGMVEISCWIYSSERQLARMRLAFLRSVLNQEVGAFDT 152
Query: 425 N-TSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPF 601
+ T+ + + +++ +++ G+K+G + F G +AF W + L+ + P
Sbjct: 153 DLTTAKIITGVTNHMSVIQDAIGEKLGHFVASFSTFFAGIIIAFASCWEVALLSFLVIPL 212
Query: 602 MMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHG 781
+++ G + A I E+ L+ I+TV +F G++ + + +++
Sbjct: 213 ILVIGATYTKQMNGISLSRNAIVSEATSIVEQTLSHIKTVFSFVGEKRAMRSFVRCMDNQ 272
Query: 782 KKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMA 961
K K++ + G GL F + + S+ L W+G V S + G + S++ G
Sbjct: 273 YKLSKKEAVIKGIGLGLFQAVTFCSWALMVWIGAVAVTSRKATGGGTIAAIMSILFG--- 329
Query: 962 LGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTR 1141
A +++VI R P I +Y G K+ G I +V F YP+R
Sbjct: 330 ----------------AXKXVFKVIKRKPSI-SYEKHGSVLGKVHGEIKFRRVHFAYPSR 372
Query: 1142 ADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIK 1321
D IL+G SL G+ VALVGSSGCGKST+I LLQRFY+P +G ILID I+ +++
Sbjct: 373 QDKPILQGFSLSIPAGKVVALVGSSGCGKSTVISLLQRFYDPTSGSILIDGHSIKKLDLE 432
Query: 1322 YLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEGLNTLV 1501
LR+ + VSQEP+LF+ +I+ N+R G+ D +D++I +A + AN FI P T V
Sbjct: 433 SLRRNIASVSQEPSLFSGTIKDNLRIGKMDANDDEITKAARTANVHSFISKLPNEYLTEV 492
Query: 1502 GDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIV 1681
G+RGVQ+SGGQKQRIAIARA++++P ILLLDEATSALD+ESE +VQ ALE A GRT I+
Sbjct: 493 GERGVQLSGGQKQRIAIARAMLKDPPILLLDEATSALDSESEKLVQDALEKAMSGRTVIL 552
Query: 1682 IAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVF--------ADVDD 1837
IAHR+ST+ NAD I+V++ G+V + GTH+ LIE+ Y + Q A D
Sbjct: 553 IAHRMSTIVNADTIVVVENGKVAQTGTHQELIEKSTFYSNVCSMQNIEKEAGTRVASSSD 612
Query: 1838 KPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXGA 2017
+ E + RQ S ++G N Q G
Sbjct: 613 NVIEDEIDEVYDRQLSPKQGQQNKLEQ---------LNSKQPKQEVRKEIHPFFRLWYGL 663
Query: 2018 VKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGH 2197
K ++ KIL I G P F F I + + D K+
Sbjct: 664 QKDDIAKIL-----------LGSSSAAISGISKPLFGYFIMTIGVAYYDLD---AKRKVS 709
Query: 2198 FWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGR 2377
++L+F + S +FQ ++GV E+ +R ++ +VLR + +F+ PK+ G
Sbjct: 710 KYSLIFFTAGVITLASNIFQHYIYGVVGEKAMKILREAIFSSVLRNELGWFEKPKNGVGF 769
Query: 2378 ITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQA 2557
+T+R+ +D +K+ I R+ I I+S+ ++ Y W+M + A+ P +G
Sbjct: 770 LTSRIVSDTSTVKTIISDRMAVIVQCISSILIATVVSMYVNWRMGLVSWAVMPCHFIGGL 829
Query: 2558 LMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNIS 2737
+ K G A + A EA NIRTV + + ++ L P
Sbjct: 830 IQAKAAKGFYGDSAIAHQELVSLASEAASNIRTVASFVYEDEIIKKAELSLQEPMRVTKI 889
Query: 2738 KAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFA 2917
+++ G+ G + + +A A + L+ K EN +R S + +I
Sbjct: 890 ESMKYGVVQGISLCLWNIAHAVALWYTTVLVQRKQASF--ENSIRSYQIFSLTVPSITEL 947
Query: 2918 ASYFPEYIKATFAAGLIFNMLEEEPRI-DGMTSSGTYPQLSGEVKLNKVFFRYPERPAVP 3094
+ P + A F ML+ + +I + + L G + V F YP RP V
Sbjct: 948 WTLIPMVMSAIAVLNPAFEMLDRDTQIVPDRPENPSDGWLMGRTEFQDVSFNYPSRPEVT 1007
Query: 3095 ILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRK 3274
IL G ++ ++PGQ +ALVGPSG GKS+V++LL R YDP G V +DN +++ N + LRK
Sbjct: 1008 ILDGFSLVIEPGQRVALVGPSGAGKSSVLALLLRFYDPQRGRVLIDNKNIKDYNLRWLRK 1067
Query: 3275 HIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGE 3454
I LV QEPILF++SIR+NI YG + E + +I A +ANIH+FI LP GY+T VG
Sbjct: 1068 QIGLVQQEPILFNSSIRDNISYGSE--ETSETEIIQAAMEANIHEFISSLPKGYDTVVGR 1125
Query: 3455 KGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAA-KDR----- 3616
KG+QLSGGQKQRIAIAR L++ P ILLLDEATSALD ESE+ V +L A KDR
Sbjct: 1126 KGSQLSGGQKQRIAIARTLLKRPVILLLDEATSALDGESERVVMSSLGAKDWKDRNEGSS 1185
Query: 3617 --TCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELI-AKRGAYFALTQKQSS 3769
T I VAHRLST++N+ I+V++ G+VVE G H+ LI A G Y L QS+
Sbjct: 1186 KITSITVAHRLSTVINSDTIVVMERGKVVELGNHHTLITADDGVYSRLFHLQSN 1239
Score = 308 bits (789), Expect = 7e-82
Identities = 193/580 (33%), Positives = 304/580 (52%), Gaps = 5/580 (0%)
Frame = +2
Query: 2060 EWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHFWALMFLV-----L 2224
+W+ +I G P L + ++ + DQ +G AL +V +
Sbjct: 52 DWLLMALGTVGSIIHGMAFPVGYLLLGKALDAYGTNINDQ---EGMVHALYKVVPFVWYM 108
Query: 2225 AAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDA 2404
AA + + + S + ++ER R+R R+VL Q+ FD + +I T +
Sbjct: 109 AAATLPAGMVEISCWIYSSERQLARMRLAFLRSVLNQEVGAFDTDL-TTAKIITGVTNHM 167
Query: 2405 PNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGS 2584
I+ AI +LG + ++ G+ IAF W++A L + P + V A K G
Sbjct: 168 SVIQDAIGEKLGHFVASFSTFFAGIIIAFASCWEVALLSFLVIPLILVIGATYTKQMNGI 227
Query: 2585 ATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTY 2764
+ S + A + + +I+TV + + + F +D + + +A+I+G+
Sbjct: 228 SLSRNAIVSEATSIVEQTLSHIKTVFSFVGEKRAMRSFVRCMDNQYKLSKKEAVIKGIGL 287
Query: 2765 GFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIK 2944
G ++ F ++A G + + + + +I F
Sbjct: 288 GLFQAVTFCSWALMVWIGAVAVTSRKAT--GGGTIAAIMSILFG---------------- 329
Query: 2945 ATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVK 3124
A +F +++ +P I ++ GE+K +V F YP R PILQG ++ +
Sbjct: 330 ---AXKXVFKVIKRKPSISYEKHGSVLGKVHGEIKFRRVHFAYPSRQDKPILQGFSLSIP 386
Query: 3125 PGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPI 3304
G+ +ALVG SGCGKSTVISLL+R YDP G++ +D + +++++ + LR++IA VSQEP
Sbjct: 387 AGKVVALVGSSGCGKSTVISLLQRFYDPTSGSILIDGHSIKKLDLESLRRNIASVSQEPS 446
Query: 3305 LFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQK 3484
LF +I++N+ G + ++I A AN+H FI +LP+ Y T VGE+G QLSGGQK
Sbjct: 447 LFSGTIKDNLRIGKM--DANDDEITKAARTANVHSFISKLPNEYLTEVGERGVQLSGGQK 504
Query: 3485 QRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAG 3664
QRIAIARA++++P ILLLDEATSALD+ESEK VQ AL+ A RT I++AHR+STIVNA
Sbjct: 505 QRIAIARAMLKDPPILLLDEATSALDSESEKLVQDALEKAMSGRTVILIAHRMSTIVNAD 564
Query: 3665 CIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSSNQSGG 3784
I+VV+NG+V + GTH ELI K Y + Q+ + G
Sbjct: 565 TIVVVENGKVAQTGTHQELIEKSTFYSNVCSMQNIEKEAG 604
Score = 302 bits (773), Expect = 5e-80
Identities = 196/603 (32%), Positives = 311/603 (51%), Gaps = 14/603 (2%)
Frame = +2
Query: 50 FQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEK 229
F+L+ D + +G + +G+ PL + +T+G + D ++
Sbjct: 657 FRLWYGLQKDDIAKILLGSSSAAISGISKPLFGYFI-------MTIGVAYYDLDA----- 704
Query: 230 AAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEI 409
+V + L + G A+ Q + V+ EK R F SV+R E+
Sbjct: 705 -------KRKVSKYSLIFFTAGVITLASNIFQHYIYGVVGEKAMKILREAIFSSVLRNEL 757
Query: 410 AWYDK--NTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIM 583
W++K N G L++++ + V+ D++ + Q ++ + V+ +W + L+
Sbjct: 758 GWFEKPKNGVGFLTSRIVSDTSTVKTIISDRMAVIVQCISSILIATVVSMYVNWRMGLVS 817
Query: 584 MSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYE 763
++ P I GL + +A E ++IRTV +F ++ K+ E
Sbjct: 818 WAVMPCHFIGGLIQAKAAKGFYGDSAIAHQELVSLASEAASNIRTVASFVYEDEIIKKAE 877
Query: 764 DALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSV 943
+L+ + +S G + ++ +A W T V + + + S
Sbjct: 878 LSLQEPMRVTKIESMKYGVVQGISLCLWNIAHAVALWYTTVLV---QRKQASFENSIRSY 934
Query: 944 MMGSMALGQAGQQFATIGTALGAAASL---YEVIDRIPEIDAYSTEGQTPSKISGRISVN 1114
+ S+ + + + I + A A L +E++DR +I E + + GR
Sbjct: 935 QIFSLTVPSITELWTLIPMVMSAIAVLNPAFEMLDRDTQIVPDRPENPSDGWLMGRTEFQ 994
Query: 1115 KVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDD 1294
V F YP+R +V IL G SL +PGQ VALVG SG GKS+++ LL RFY+P G++LID+
Sbjct: 995 DVSFNYPSRPEVTILDGFSLVIEPGQRVALVGPSGAGKSSVLALLLRFYDPQRGRVLIDN 1054
Query: 1295 IPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKT 1474
I+D+N+++LR+ +G+V QEP LFN+SI NI YG + S+ +I +A EAN +FI +
Sbjct: 1055 KNIKDYNLRWLRKQIGLVQQEPILFNSSIRDNISYGSEETSETEIIQAAMEANIHEFISS 1114
Query: 1475 FPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSAL-- 1648
P+G +T+VG +G Q+SGGQKQRIAIAR L++ P ILLLDEATSALD ESE +V S+L
Sbjct: 1115 LPKGYDTVVGRKGSQLSGGQKQRIAIARTLLKRPVILLLDEATSALDGESERVVMSSLGA 1174
Query: 1649 ------ENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLI-EQKGLYHELV 1807
S T+I +AHRLSTV N+D I+VM+ G+V+E+G H TLI G+Y L
Sbjct: 1175 KDWKDRNEGSSKITSITVAHRLSTVINSDTIVVMERGKVVELGNHHTLITADDGVYSRLF 1234
Query: 1808 HAQ 1816
H Q
Sbjct: 1235 HLQ 1237
>gi|9294508|dbj|BAB02613.1| P-glycoprotein; multi-drug resistance
related; ABC transporter-like protein [Arabidopsis
thaliana]
Length = 1241
Score = 651 bits (1679), Expect = 0.0
Identities = 399/1234 (32%), Positives = 645/1234 (51%), Gaps = 12/1234 (0%)
Frame = +2
Query: 56 LYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAA 235
++R+ +D +++ +G + + G+ + + + + TLG +P+ST
Sbjct: 21 IFRFADWIDIVLMVLGSVGAIGDGMSTNVSLVFVSRIMN---TLGYSQHNPSST------ 71
Query: 236 ARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAW 415
F E+ + L +VYLG I F++ C+ E+ + RR + +V+RQE+++
Sbjct: 72 ---NFKEEIQKCSLYFVYLGLAILGVAFMEGYCWSKTSERQVMKIRRTYLEAVLRQEVSF 128
Query: 416 YDKNTSGT-LSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSL 592
+D + S + + + + + +++ +KV + ++ FI G + + W LT++ +
Sbjct: 129 FDSDISTSEIIHTISTDTSLIQQLLSEKVPIFLMHISVFITGLVFSAYFSWRLTVVAIPT 188
Query: 593 SPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDAL 772
++I GL +Y A I E+ L+SI+T+++F + K+Y + L
Sbjct: 189 LVLLLIPGLIYGKYLVHLSKKSFKEYTKANSIVEQALSSIKTILSFTAETQIIKKYSEVL 248
Query: 773 EHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMG 952
E KK G+K+ G + S I + + W G+ V + G + S ++G
Sbjct: 249 ERHKKLGLKQGLAKGLAVGSSG-ISFTIWAFLAWYGSRLVMHKQETGGRIYAAGISFVLG 307
Query: 953 SMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTE-GQTPS-KISGRISVNKVEF 1126
++LG A + A AAA + IDRI EID T+ G P K+ GR+ +V
Sbjct: 308 GISLGTALTEIRYFSEASVAAARICSRIDRISEIDGEDTKKGFIPGEKMKGRVEFERVTL 367
Query: 1127 TYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIE 1306
Y +R + ILK +L GQ+VAL+G+SG GKST+I LLQRFY+P G + ID I+
Sbjct: 368 VYLSRPETIILKDFTLTVDVGQSVALMGASGSGKSTVIALLQRFYDPCEGFVRIDGFDIK 427
Query: 1307 DFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEG 1486
+K++RQ +GVVSQ+ LF TSI +N+ +G++ S +++ A K ANA FI P G
Sbjct: 428 TLQLKWMRQHIGVVSQDHALFGTSIMENLMFGKNKASMDEVISAAKAANAHGFITQLPNG 487
Query: 1487 LNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRG 1666
+T +G+RG +SGGQKQRIAIARA++RNP ILLLDEATSALD ESE+++Q+AL+ + G
Sbjct: 488 YDTHIGNRGALLSGGQKQRIAIARAIIRNPVILLLDEATSALDGESETLIQNALDQVAAG 547
Query: 1667 RTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVF------AD 1828
RTT+V+AH+LSTVR A+ I +++ G V E+G+HE L+ + Y +LV Q D
Sbjct: 548 RTTLVVAHKLSTVRGANIIAMLENGSVRELGSHEDLMTKNNHYAKLVKLQRQFGHEHQQD 607
Query: 1829 VDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXX 2008
+ D+ E ++R S T S +
Sbjct: 608 LQDRVNSPEIQQRWS-------------TMNSVIRLSNRSSPDLIVSPITLESNHTTKIN 654
Query: 2009 XGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKK 2188
+ ++L + PEW GA+ P ++L +I+ F +M+
Sbjct: 655 ENIPSTSFTRLLPFVSPEWKSSLVGCISATTFGAIQPVYALSIGGMISAFFAKSSQEMQD 714
Query: 2189 DGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHS 2368
H ++L+F+ L + T L Q F ERL R+R K+ + + +FD+ ++
Sbjct: 715 KIHIYSLIFISLTFLSITLNLLQHYSFAKMGERLMQRLRLKMLEKIFTFEPAWFDVEENF 774
Query: 2369 PGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAV 2548
I +RL + +KS + R+ + I+ V + I W++A +++A+ P +
Sbjct: 775 TSEICSRLNNEVSIVKSLVADRISLLVQTISGVTIAMIIGLLISWKLALVMIAVQPLSIL 834
Query: 2549 GQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCS-HLDAPHG 2725
+ + A + + A EAI N + V +L K+ IF + +A
Sbjct: 835 CFYTKKVLLSKISNNYAYAQNRSSQIASEAIYNHKIVTSLGSTKKIIEIFDNAQYEAKRK 894
Query: 2726 GNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGT 2905
G A + G G A + F T+A F +G L+ + +V + F + +
Sbjct: 895 GR-KAAWLAGFGMGSAQCLTFLTWALDFWYGGVLVQKGEI--SAGDVFKTFFVLVSTGKV 951
Query: 2906 IGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVFFRYPERP 3085
I A S + K T A +FN+L+ + + G ++L + F YP RP
Sbjct: 952 IAEAGSMTSDLAKGTAAISSVFNILDRPSSHENTNHGEKMGTIQGRIELKNIDFSYPNRP 1011
Query: 3086 AVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKH 3265
++ +L+ ++ +KPG ++ LVG SGCGKSTVI+L++R YD G V +D+ +LR +N K
Sbjct: 1012 SILVLRDFSLDIKPGTSIGLVGTSGCGKSTVIALIQRFYDVEIGCVKIDSENLRDINIKW 1071
Query: 3266 LRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETR 3445
RKH ALVSQEP+++ SI++NI+ G E T +++ A AN H FI + GY+T
Sbjct: 1072 YRKHTALVSQEPVVYSGSIQDNIILGRP--EATEDEVVEAAKAANAHDFISAMEKGYKTE 1129
Query: 3446 VGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALD--AAAKDRT 3619
GE+G QLSGGQKQRIAIARA +R+P ILLLDE TS+LD+ SE++VQ AL A+++ T
Sbjct: 1130 CGERGVQLSGGQKQRIAIARAFLRSPIILLLDEVTSSLDSNSEQEVQDALARIMASRNMT 1189
Query: 3620 CIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNEL 3721
+VVAHRL+T+ N CI ++ +G V+E G+++ L
Sbjct: 1190 TVVVAHRLNTLKNLDCIALIVDGTVIETGSYDHL 1223
Score = 312 bits (799), Expect = 5e-83
Identities = 174/504 (34%), Positives = 280/504 (55%), Gaps = 6/504 (1%)
Frame = +2
Query: 320 LQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYD--KNTSGTLSNKLFDNLERVREGTGD 493
LQ F + E+L R R + + E AW+D +N + + ++L + + V+ D
Sbjct: 736 LQHYSFAKMGERLMQRLRLKMLEKIFTFEPAWFDVEENFTSEICSRLNNEVSIVKSLVAD 795
Query: 494 KVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFXXXXXXXXXXXXXXQYA 673
++ L Q ++ + W L L+M+++ P ++C F YA
Sbjct: 796 RISLLVQTISGVTIAMIIGLLISWKLALVMIAVQPLSILC--FYTKKVLLSKISNNYAYA 853
Query: 674 V--AGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVII 847
+ IA E + + + V + + + +++A K+ G K ++L G G+ S +
Sbjct: 854 QNRSSQIASEAIYNHKIVTSLGSTKKIIEIFDNAQYEAKRKGRKAAWLAGFGMGSAQCLT 913
Query: 848 YASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLY 1027
+ ++ L FW G V G + +G V FF ++ + +AG + + A +S++
Sbjct: 914 FLTWALDFWYGGVLVQKGEISAGDVFKTFFVLVSTGKVIAEAGSMTSDLAKGTAAISSVF 973
Query: 1028 EVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALV 1207
++DR P + G+ I GRI + ++F+YP R + +L+ SLD +PG ++ LV
Sbjct: 974 NILDR-PSSHENTNHGEKMGTIQGRIELKNIDFSYPNRPSILVLRDFSLDIKPGTSIGLV 1032
Query: 1208 GSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQ 1387
G+SGCGKST+I L+QRFY+ + G + ID + D NIK+ R+ +VSQEP +++ SI+
Sbjct: 1033 GTSGCGKSTVIALIQRFYDVEIGCVKIDSENLRDINIKWYRKHTALVSQEPVVYSGSIQD 1092
Query: 1388 NIRYGRSDVSDEDIARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALV 1567
NI GR + +++++ A K ANA DFI +G T G+RGVQ+SGGQKQRIAIARA +
Sbjct: 1093 NIILGRPEATEDEVVEAAKAANAHDFISAMEKGYKTECGERGVQLSGGQKQRIAIARAFL 1152
Query: 1568 RNPKILLLDEATSALDAESESIVQSALEN--ASRGRTTIVIAHRLSTVRNADKIIVMKAG 1741
R+P ILLLDE TS+LD+ SE VQ AL ASR TT+V+AHRL+T++N D I ++ G
Sbjct: 1153 RSPIILLLDEVTSSLDSNSEQEVQDALARIMASRNMTTVVVAHRLNTLKNLDCIALIVDG 1212
Query: 1742 QVMEVGTHETLIEQKGLYHELVHA 1813
V+E G+++ L G + L HA
Sbjct: 1213 TVIETGSYDHLKNIGGQFSRLAHA 1236
Score = 290 bits (743), Expect = 1e-76
Identities = 193/556 (34%), Positives = 302/556 (53%), Gaps = 11/556 (1%)
Frame = +2
Query: 2129 LFFSQIINVFS----NPDRDQMKKDGHFWALMFLVLA-AVQGTSMLFQCSLFGVAAERLT 2293
+F S+I+N NP K++ +L F+ L A+ G + + + + +ER
Sbjct: 52 VFVSRIMNTLGYSQHNPSSTNFKEEIQKCSLYFVYLGLAILGVAFM-EGYCWSKTSERQV 110
Query: 2294 MRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGG 2473
M+IR VLRQ+ ++FD S I ++TD I+ + ++ I+
Sbjct: 111 MKIRRTYLEAVLRQEVSFFDSDI-STSEIIHTISTDTSLIQQLLSEKVPIFLMHISVFIT 169
Query: 2474 GLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIR 2653
GL + Y+ W++ + + + + + KY + KE A +A+ +I+
Sbjct: 170 GLVFSAYFSWRLTVVAIPTLVLLLIPGLIYGKYLVHLSKKSFKEYTKANSIVEQALSSIK 229
Query: 2654 TVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIF 2833
T+ + T +T++ + L+ + + + +GL G ++ I F +A +G L+
Sbjct: 230 TILSFTAETQIIKKYSEVLERHKKLGLKQGLAKGLAVG-SSGISFTIWAFLAWYGSRLVM 288
Query: 2834 DKNVLMEPENVLRVLFA-ISFSFG--TIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDG 3004
K E R+ A ISF G ++G A + + +A+ AA I + ++ IDG
Sbjct: 289 HKQ-----ETGGRIYAAGISFVLGGISLGTALTEIRYFSEASVAAARICSRIDRISEIDG 343
Query: 3005 M-TSSGTYP--QLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKST 3175
T G P ++ G V+ +V Y RP IL+ + V GQ++AL+G SG GKST
Sbjct: 344 EDTKKGFIPGEKMKGRVEFERVTLVYLSRPETIILKDFTLTVDVGQSVALMGASGSGKST 403
Query: 3176 VISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPG 3355
VI+LL+R YDP EG V +D D++ + K +R+HI +VSQ+ LF TSI EN+++G
Sbjct: 404 VIALLQRFYDPCEGFVRIDGFDIKTLQLKWMRQHIGVVSQDHALFGTSIMENLMFG--KN 461
Query: 3356 EYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILL 3535
+ + +++ +A AN H FI +LP+GY+T +G +G LSGGQKQRIAIARA+IRNP ILL
Sbjct: 462 KASMDEVISAAKAANAHGFITQLPNGYDTHIGNRGALLSGGQKQRIAIARAIIRNPVILL 521
Query: 3536 LDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHN 3715
LDEATSALD ESE +Q ALD A RT +VVAH+LST+ A I +++NG V E G+H
Sbjct: 522 LDEATSALDGESETLIQNALDQVAAGRTTLVVAHKLSTVRGANIIAMLENGSVRELGSHE 581
Query: 3716 ELIAKRGAYFALTQKQ 3763
+L+ K Y L + Q
Sbjct: 582 DLMTKNNHYAKLVKLQ 597
>gi|27368841|emb|CAD59578.1| MDR-like ABC transporter [Oryza sativa
(japonica cultivar-group)]
gi|37806005|dbj|BAC99418.1| MDR-like ABC transporter [Oryza sativa
(japonica cultivar-group)]
gi|37806249|dbj|BAC99766.1| MDR-like ABC transporter [Oryza sativa
(japonica cultivar-group)]
Length = 1266
Score = 649 bits (1674), Expect = 0.0
Identities = 412/1252 (32%), Positives = 650/1252 (51%), Gaps = 13/1252 (1%)
Frame = +2
Query: 50 FQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEK 229
F L RY +D L++ G + S G+G P MS + V + +G N+ + +
Sbjct: 44 FGLLRYADGLDWLLMVAGTMGSFLHGMG-PSMSYYL--VGKGIDVVG------NNIGNRE 94
Query: 230 AAARAEFSHEVIQNCLKYVY-LGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQE 406
A HE + + Y++ L G ++ +C+M ++ +R R + SV+ Q+
Sbjct: 95 ATV-----HE-LSKLIPYMWALAIITLPGGMIEITCWMYTSQRQMSRMRMAYLRSVLSQD 148
Query: 407 IAWYDKN-TSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIM 583
I +D + T+ + +++ +++ G+K+G + F+ VAF W + ++
Sbjct: 149 IGAFDTDLTTANVMAGATNHMSAIQDAIGEKLGHFLSNFSTFLVSIIVAFVCCWEVGMLS 208
Query: 584 MSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYE 763
M + P +++ G + A + E+ L+ I+TV +F G+ K +
Sbjct: 209 MLVVPMLLMVGATYAKMMIDASMKRIALVSAATTVVEQTLSHIKTVFSFVGENSAIKSFT 268
Query: 764 DALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSV 943
++ K ++ G GL + + SY L WVG V + G + ++
Sbjct: 269 KCMDKQYKLSKIEAMTKGLGLGMLQIATFCSYSLTVWVGAAAVVDRSAKGGETIAAVINI 328
Query: 944 MMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVE 1123
+ ++ + A + A A ++EVI+R P I +Y + G K++G I + +V+
Sbjct: 329 LSAAIYISNAAPDLQSFSQAKAAGKEVFEVINRNPAI-SYESNGTILEKVTGNIEIREVD 387
Query: 1124 FTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPI 1303
F YP+R D IL+ SL G+ VALVGSSGCGKST+I L+QRFY+P +G ILID I
Sbjct: 388 FMYPSRVDKPILRSFSLSIPAGKVVALVGSSGCGKSTVISLVQRFYDPISGNILIDGQNI 447
Query: 1304 EDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPE 1483
++ ++K LR+ +G VSQEP+LF+ +I N+R G+ D +DE+I K AN F+ P
Sbjct: 448 KELDLKSLRRSIGSVSQEPSLFSGTIMDNLRIGKMDGTDEEIIEIAKSANVHSFVSKLPN 507
Query: 1484 GLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASR 1663
+T VG+RGVQ+SGGQKQRIAIARA++++P ILLLDEATSALD+ESE +VQ AL+ A +
Sbjct: 508 QYSTEVGERGVQLSGGQKQRIAIARAMLKDPPILLLDEATSALDSESEKLVQEALDGAMK 567
Query: 1664 GRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVDDKP 1843
GRT I+IAHR+ST+ N+DKI+V++ G+V + GTHE L+E+ Y + Q K
Sbjct: 568 GRTVILIAHRMSTIINSDKIVVVENGKVAQSGTHEELLEKSPFYSSVCSMQNLEKESGKS 627
Query: 1844 KKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXXXXXXXGAVK 2023
+++ ++ Q + S + + + G
Sbjct: 628 EERFTDQVREEQDNGSGTSNEPSSTAHEQEKSLELNPNQPKQDIRNRASAFYRMFLGTFM 687
Query: 2024 ANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHFW 2203
KIL I G P F+ + + + +PD ++ +
Sbjct: 688 LEPGKIL-----------LGSTAAAISGVSKPIFAFYIMTVAIAYFDPDAKRIVAK---Y 733
Query: 2204 ALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRIT 2383
+++ ++ + S +FQ ++G+ ER +R ++ +L+ + +F+ PK+S G +T
Sbjct: 734 SIILFLIGLLTFFSNIFQHYIYGLVGERAMNNLREALFSVILQNEIGWFEQPKNSVGFLT 793
Query: 2384 TRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALM 2563
+R+ D IK+ I R+ I I+S+ G++ W+M + A+ P + +
Sbjct: 794 SRVVGDTSMIKTIISDRMSVIVQCISSILIATGLSIGVNWRMGLVAWALMPCQFIAGLVQ 853
Query: 2564 MKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKA 2743
++ G AT + EA+ NIRTV + + ++ L P + ++
Sbjct: 854 VRSAKGFATDTSTSHRKLISLTSEAVSNIRTVASFGQEEEILKKADLSLQEPMQTSRIES 913
Query: 2744 IIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAAS 2923
I G+ G + + T+A A + + L+ DK+ L EN +R AI+ + +I S
Sbjct: 914 IKYGVVQGVSLCLWHMTHAIALSYTIVLL-DKS-LATFENCVRAYQAIALTITSITELWS 971
Query: 2924 YFPEYIKATFAAGLIFNMLEEEPRI-DGMTSSGTYPQLSGEVKLNKVFFRYPERPAVPIL 3100
P I A ++L+ E +I +++G ++ V F YP R V IL
Sbjct: 972 LIPMVISAIAILDPALDILDRETQIVPDEPKVHCEDRITGNIEFQDVSFSYPSRQDVIIL 1031
Query: 3101 QGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHI 3280
G ++ ++PGQ +ALVGPSG GKST++SLL R YDP G V VD D+R+ N + LRK I
Sbjct: 1032 DGFSLAIEPGQRVALVGPSGAGKSTIVSLLLRFYDPCRGQVLVDGKDVREYNLRFLRKQI 1091
Query: 3281 ALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKG 3460
LV QEPILF+ SIRENI YG + T +I A +ANIH+FI L +GY+T VG+KG
Sbjct: 1092 GLVQQEPILFNLSIRENISYGNEGASET--EIVEAAMEANIHEFISGLSNGYDTVVGDKG 1149
Query: 3461 TQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDA---------AAKD 3613
+QLSGGQKQRIAIAR +++ P ILLLDEATSALD E+EK V +L A +
Sbjct: 1150 SQLSGGQKQRIAIARTILKRPVILLLDEATSALDGETEKVVMSSLAAKEWKSKEGELSNK 1209
Query: 3614 RTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELI-AKRGAYFALTQKQS 3766
T I +AHRLST+ +A I+V+ G+VVE G+H L+ G Y L QS
Sbjct: 1210 ITSITIAHRLSTVTSADVIVVMDKGEVVEMGSHETLVTTSNGVYSRLYCMQS 1261
Score = 295 bits (755), Expect = 6e-78
Identities = 193/597 (32%), Positives = 310/597 (51%), Gaps = 9/597 (1%)
Frame = +2
Query: 2021 KANLFKILRYARP-EWIYXXXXXXXXLIQGAVMPAFSLFF-SQIINVFSN-------PDR 2173
K F +LRYA +W+ + G + P+ S + + I+V N
Sbjct: 40 KFPFFGLLRYADGLDWLLMVAGTMGSFLHG-MGPSMSYYLVGKGIDVVGNNIGNREATVH 98
Query: 2174 DQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFD 2353
+ K + WAL + L G + C ++ ++R R+R R+VL QD FD
Sbjct: 99 ELSKLIPYMWALAIITLP---GGMIEITCWMY--TSQRQMSRMRMAYLRSVLSQDIGAFD 153
Query: 2354 MPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIF 2533
+ + I+ AI +LG + ++ + +AF W++ L M +
Sbjct: 154 TDL-TTANVMAGATNHMSAIQDAIGEKLGHFLSNFSTFLVSIIVAFVCCWEVGMLSMLVV 212
Query: 2534 PFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLD 2713
P + + A K ++ + A + + +I+TV + + F +D
Sbjct: 213 PMLLMVGATYAKMMIDASMKRIALVSAATTVVEQTLSHIKTVFSFVGENSAIKSFTKCMD 272
Query: 2714 APHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISF 2893
+ + +A+ +GL G F +Y+ G + D++ E + V+ +S
Sbjct: 273 KQYKLSKIEAMTKGLGLGMLQIATFCSYSLTVWVGAAAVVDRSA-KGGETIAAVINILSA 331
Query: 2894 SFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVFFRY 3073
+ I AA + +A A +F ++ P I ++ +++G +++ +V F Y
Sbjct: 332 AI-YISNAAPDLQSFSQAKAAGKEVFEVINRNPAISYESNGTILEKVTGNIEIREVDFMY 390
Query: 3074 PERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQM 3253
P R PIL+ ++ + G+ +ALVG SGCGKSTVISL++R YDP+ G + +D +++++
Sbjct: 391 PSRVDKPILRSFSLSIPAGKVVALVGSSGCGKSTVISLVQRFYDPISGNILIDGQNIKEL 450
Query: 3254 NPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDG 3433
+ K LR+ I VSQEP LF +I +N+ G G T E+I AN+H F+ +LP+
Sbjct: 451 DLKSLRRSIGSVSQEPSLFSGTIMDNLRIGKMDG--TDEEIIEIAKSANVHSFVSKLPNQ 508
Query: 3434 YETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKD 3613
Y T VGE+G QLSGGQKQRIAIARA++++P ILLLDEATSALD+ESEK VQ ALD A K
Sbjct: 509 YSTEVGERGVQLSGGQKQRIAIARAMLKDPPILLLDEATSALDSESEKLVQEALDGAMKG 568
Query: 3614 RTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSSNQSGG 3784
RT I++AHR+STI+N+ I+VV+NG+V + GTH EL+ K Y ++ Q+ + G
Sbjct: 569 RTVILIAHRMSTIINSDKIVVVENGKVAQSGTHEELLEKSPFYSSVCSMQNLEKESG 625
Score = 295 bits (755), Expect = 6e-78
Identities = 180/599 (30%), Positives = 307/599 (51%), Gaps = 12/599 (2%)
Frame = +2
Query: 44 SIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTAS 223
+ ++++ T ++ + +G + +GV P+ + + +T+ + DP+
Sbjct: 677 AFYRMFLGTFMLEPGKILLGSTAAAISGVSKPIFAFYI-------MTVAIAYFDPD---- 725
Query: 224 EKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQ 403
A R + +I +G F + Q + ++ E+ N R F +++
Sbjct: 726 ---AKRIVAKYSII-----LFLIGLLTFFSNIFQHYIYGLVGERAMNNLREALFSVILQN 777
Query: 404 EIAWYD--KNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
EI W++ KN+ G L++++ + ++ D++ + Q ++ + ++ +W + L
Sbjct: 778 EIGWFEQPKNSVGFLTSRVVGDTSMIKTIISDRMSVIVQCISSILIATGLSIGVNWRMGL 837
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
+ +L P I GL + + E +++IRTV +F +E K+
Sbjct: 838 VAWALMPCQFIAGLVQVRSAKGFATDTSTSHRKLISLTSEAVSNIRTVASFGQEEEILKK 897
Query: 758 YEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFF 937
+ +L+ +T +S G + + ++ +A + + +
Sbjct: 898 ADLSLQEPMQTSRIESIKYGVVQGVSLCLWHMTHAIALSYTIVLLDKSLATFENCVRAYQ 957
Query: 938 SVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNK 1117
++ + ++ + + +A+ +++DR +I + +I+G I
Sbjct: 958 AIALTITSITELWSLIPMVISAIAILDPALDILDRETQIVPDEPKVHCEDRITGNIEFQD 1017
Query: 1118 VEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDI 1297
V F+YP+R DV IL G SL +PGQ VALVG SG GKSTI+ LL RFY+P GQ+L+D
Sbjct: 1018 VSFSYPSRQDVIILDGFSLAIEPGQRVALVGPSGAGKSTIVSLLLRFYDPCRGQVLVDGK 1077
Query: 1298 PIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTF 1477
+ ++N+++LR+ +G+V QEP LFN SI +NI YG S+ +I A EAN +FI
Sbjct: 1078 DVREYNLRFLRKQIGLVQQEPILFNLSIRENISYGNEGASETEIVEAAMEANIHEFISGL 1137
Query: 1478 PEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALE-- 1651
G +T+VGD+G Q+SGGQKQRIAIAR +++ P ILLLDEATSALD E+E +V S+L
Sbjct: 1138 SNGYDTVVGDKGSQLSGGQKQRIAIARTILKRPVILLLDEATSALDGETEKVVMSSLAAK 1197
Query: 1652 -------NASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLI-EQKGLYHEL 1804
S T+I IAHRLSTV +AD I+VM G+V+E+G+HETL+ G+Y L
Sbjct: 1198 EWKSKEGELSNKITSITIAHRLSTVTSADVIVVMDKGEVVEMGSHETLVTTSNGVYSRL 1256
>gi|49089656|ref|XP_406486.1| hypothetical protein AN2349.2
[Aspergillus nidulans FGSC A4]
gi|40745304|gb|EAA64460.1| hypothetical protein AN2349.2 [Aspergillus
nidulans FGSC A4]
Length = 1284
Score = 644 bits (1661), Expect = 0.0
Identities = 430/1282 (33%), Positives = 652/1282 (50%), Gaps = 44/1282 (3%)
Frame = +2
Query: 53 QLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKA 232
+++ + + ++ AV I+ +CA+G G+ L ++I G FVT+ T F + ST
Sbjct: 41 RIFTFAGRTELILQAVAILAACASGAGIALQNLIFGQ----FVTVITDFTNGISTP---- 92
Query: 233 AARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIA 412
A+F + L +VYLG + + ++ R + + + QE+A
Sbjct: 93 ---ADFRDNAAELALYFVYLGIARLVLSYTYNTLLTYAAYRIVRNIRHAYLKAALSQEVA 149
Query: 413 WYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSL 592
+YD + G+++ + N + ++ G DK+GL FQ +A F+ F +AF W LTLI + +
Sbjct: 150 YYDFGSGGSIAAQATSNGKLIQAGASDKIGLLFQGLAAFVTAFIIAFVVQWKLTLICICI 209
Query: 593 SPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDAL 772
+ +A A AE +L ++ V AF ++ +++++ L
Sbjct: 210 PVATIGTTGVVAAVEAGHETRILQIHAQANSFAEGILAGVKAVHAFGMRDSLVRKFDEYL 269
Query: 773 EHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRL-ESGTVLTVFFSVMM 949
K G K S L+G ++ + IIY Y LAFW G + G + +G + TV SV++
Sbjct: 270 VEAHKVGKKISPLLGLLFSAEYTIIYLGYGLAFWQGIHMFGRGEIGTAGDIFTVLLSVVI 329
Query: 950 GSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFT 1129
S+ L A AAA L+ +IDR EI+ Y EG P ++ G + + V F+
Sbjct: 330 ASINLTLLAPYSIEFSRAASAAAQLFRLIDRESEINPYGKEGLEPERVLGDVELENVTFS 389
Query: 1130 YPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIED 1309
YPTR + +L SL G+ ALVG SG GKSTI+ LL+R+YNP +G I +D I +
Sbjct: 390 YPTRPGITVLDNFSLKVPAGKVTALVGQSGSGKSTIVGLLERWYNPTSGAIRLDGNLISE 449
Query: 1310 FNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIAR---------ALKEANAAD 1462
N+ +LR+ V +V QEP LF S+ NIRYG E+ +R A K A A +
Sbjct: 450 LNVGWLRRNVRLVQQEPVLFQGSVFDNIRYGLVGTPWENASREEQMERVQEAAKLAYAHE 509
Query: 1463 FIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQS 1642
FI +G +TL+G+RG +SGGQKQR+AIAR++V PK+LLLDEATSALD +E+IVQ
Sbjct: 510 FISELTDGYDTLIGERGGLLSGGQKQRVAIARSVVSQPKVLLLDEATSALDPHAETIVQK 569
Query: 1643 ALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVF 1822
AL+ A+ GRTTIVIAH+L+T+R AD I+VM G ++E GTHE+LI + G+Y LV Q
Sbjct: 570 ALDKAAEGRTTIVIAHKLATIRKADNIVVMSKGHIVEQGTHESLIAKDGVYAGLVKIQNL 629
Query: 1823 A-------------DVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXX 1963
A + +D + E ++R + +G +N +
Sbjct: 630 AVNASAHDNVNEEGEGEDVALLEVTETAVTRYPTSIRGRMNSIKDRDDYENHKHMD---- 685
Query: 1964 XXXXXXXXXXXXXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVM-PAFSLFFS 2140
+ A L ++R PE + + G M P ++ S
Sbjct: 686 ------------------MLAALAYLVREC-PELKWAYLVVLLGCLGGCAMYPGQAILMS 726
Query: 2141 QIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYR 2320
+++ VF+ D M G F+A M +VLAA L A+ L+ R +
Sbjct: 727 RVVEVFT-LSGDAMLDKGDFYASMLIVLAAGCLICYLAVGYATNTIAQHLSHWFRRLILH 785
Query: 2321 NVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYG 2500
++LRQD +FD +++ G + +R+ + I + Y + + A+ V +A +
Sbjct: 786 DMLRQDIQFFDREENTTGALVSRIDSYPHAILELMGYNIALVVIAVLQVVTCGILAIAFS 845
Query: 2501 WQMAFLVM--AIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTL 2674
W++ +V+ I P + G + ++ +K+ + A EA+ IRTV +L +
Sbjct: 846 WKLGLVVVFGGIPPLVGAGM-VRIRVDSRLDRQTSKKYGTSSSIASEAVNAIRTVSSLAI 904
Query: 2675 QTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLME 2854
+ + + LD ++ + +G I+++ A F +G L+ M
Sbjct: 905 EETVLRRYTEELDHAVSSSVKPMAATMICFGLTQCIEYWFQALGFWYGCRLVSLGETSMY 964
Query: 2855 PENV--LRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRI-DGMTSSGTY 3025
V L V FA S ++ S K A I + + +P + + +
Sbjct: 965 SFFVAFLSVFFAGQASAQLFQWSTS----ITKGINATNYIAWLHQLQPTVRETPENHDKG 1020
Query: 3026 PQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYD 3205
P + ++ V F YP RP PIL+G+N+ + GQ +A VG SGCGKST+I++LER YD
Sbjct: 1021 PGSGAPIAMDNVRFSYPLRPDAPILKGVNLKINKGQFIAFVGSSGCGKSTMIAMLERFYD 1080
Query: 3206 PLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGL-----QP------ 3352
P G++T+D + L +NP R +ALV QEP LF +IR+NI G+ QP
Sbjct: 1081 PTTGSITIDASTLTDINPISYRNIVALVQQEPTLFQGTIRDNISLGVFNPNTQPFFSDKD 1140
Query: 3353 --GEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPK 3526
+ EQIE+A AN F+ LP G T G G+QLSGGQ+QRIAIARALIR+PK
Sbjct: 1141 AVKSVSDEQIESALRAANAWDFVSSLPQGIYTPAGSGGSQLSGGQRQRIAIARALIRDPK 1200
Query: 3527 ILLLDEATSALDTESEKQVQVALDAAAK--DRTCIVVAHRLSTIVNAGCIMVVKNGQVVE 3700
ILLLDEATSALDTESEK VQ AL+ AA+ DR + VAHRLSTI +A I V G++ E
Sbjct: 1201 ILLLDEATSALDTESEKIVQKALEGAARDGDRLTVAVAHRLSTIKDANVICVFFGGKIAE 1260
Query: 3701 QGTHNELIAKRGAYFALTQKQS 3766
GTH ELI + G Y + + Q+
Sbjct: 1261 MGTHQELIVRGGLYRRMCEAQA 1282
Score = 298 bits (763), Expect = 7e-79
Identities = 194/594 (32%), Positives = 300/594 (49%), Gaps = 14/594 (2%)
Frame = +2
Query: 2054 RPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRD-----QMKKDGHFWALMFL 2218
R E I GA + +L F Q + V ++ + + AL F+
Sbjct: 48 RTELILQAVAILAACASGAGIALQNLIFGQFVTVITDFTNGISTPADFRDNAAELALYFV 107
Query: 2219 VLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLAT 2398
L + +L AA R+ IR + L Q+ Y+D S G I + +
Sbjct: 108 YLGIARLVLSYTYNTLLTYAAYRIVRNIRHAYLKAALSQEVAYYDFG--SGGSIAAQATS 165
Query: 2399 DAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQA-LMMKYH 2575
+ I++ ++G +F +A+ IAF W++ + + I P +G ++
Sbjct: 166 NGKLIQAGASDKIGLLFQGLAAFVTAFIIAFVVQWKLTLICICI-PVATIGTTGVVAAVE 224
Query: 2576 GGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRG 2755
G T + A A + ++ V A ++ L F +L H + + G
Sbjct: 225 AGHETRILQIHAQANSFAEGILAGVKAVHAFGMRDSLVRKFDEYLVEAHKVGKKISPLLG 284
Query: 2756 LTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPE 2935
L + +I + Y AF G+ + F + + ++ VL ++ + + A Y E
Sbjct: 285 LLFSAEYTIIYLGYGLAFWQGIHM-FGRGEIGTAGDIFTVLLSVVIASINLTLLAPYSIE 343
Query: 2936 YIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQ-LSGEVKLNKVFFRYPERPAVPILQGLN 3112
+ +A AA +F +++ E I+ G P+ + G+V+L V F YP RP + +L +
Sbjct: 344 FSRAASAAAQLFRLIDRESEINPYGKEGLEPERVLGDVELENVTFSYPTRPGITVLDNFS 403
Query: 3113 VHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVS 3292
+ V G+ ALVG SG GKST++ LLER Y+P GA+ +D N + ++N LR+++ LV
Sbjct: 404 LKVPAGKVTALVGQSGSGKSTIVGLLERWYNPTSGAIRLDGNLISELNVGWLRRNVRLVQ 463
Query: 3293 QEPILFDTSIRENIVYGL-------QPGEYTHEQIETACSKANIHKFIDELPDGYETRVG 3451
QEP+LF S+ +NI YGL E E+++ A A H+FI EL DGY+T +G
Sbjct: 464 QEPVLFQGSVFDNIRYGLVGTPWENASREEQMERVQEAAKLAYAHEFISELTDGYDTLIG 523
Query: 3452 EKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVV 3631
E+G LSGGQKQR+AIAR+++ PK+LLLDEATSALD +E VQ ALD AA+ RT IV+
Sbjct: 524 ERGGLLSGGQKQRVAIARSVVSQPKVLLLDEATSALDPHAETIVQKALDKAAEGRTTIVI 583
Query: 3632 AHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSSNQSGGAFD 3793
AH+L+TI A I+V+ G +VEQGTH LIAK G Y L + Q+ + A D
Sbjct: 584 AHKLATIRKADNIVVMSKGHIVEQGTHESLIAKDGVYAGLVKIQNLAVNASAHD 637
>gi|2360941|gb|AAB69130.1| P-glycoprotein
Length = 1341
Score = 641 bits (1653), Expect = 0.0
Identities = 395/1251 (31%), Positives = 640/1251 (50%), Gaps = 17/1251 (1%)
Frame = +2
Query: 41 ISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVT-LGTIFLDPNST 217
+S ++RY T DR+++ +G I + +G G+P S I G ++ + ++ +G++ L T
Sbjct: 116 VSPIAIFRYADTADRVLMIIGTIFAVCSGAGMPFFSFIFGRIATDLMSGVGSVELSAAKT 175
Query: 218 ASEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVM 397
+ L VY+G G+F A C+ V + R R FF +V+
Sbjct: 176 S------------------LIMVYVGIGMFVACGGHVLCWTVAASRQERRIRLNFFRAVL 217
Query: 398 RQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 577
RQ+I W+D+ + G L+ ++ + ++ G DK+ A I G+ F + W LTL
Sbjct: 218 RQDIGWHDERSPGELTARMTGDTRVIQNGINDKLSQGIMNGAMGIIGYIAGFVFSWELTL 277
Query: 578 IMMSLSPFMMICGLFXXXXXXXXXXXXXXQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 757
+M+ + PF+++ +A AG +A EV+ +IRTV F ++YE +R
Sbjct: 278 VMVGMMPFIIVMAAIIGNIVSKMTESSRKHFAKAGSLATEVMENIRTVQVFGREDYELQR 337
Query: 758 YEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFF 937
+ +A+ H + GI+K F A ++Y SY +AF+ G+ V GR + +++ F
Sbjct: 338 FAEAVLHAQDRGIRKEFAGSLSEAVIMALVYLSYTIAFFFGSYLVEWGRRDMADIISTFL 397
Query: 938 SVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNK 1117
+V+MGS LG A + AA +++ IDR+P +D +G + I
Sbjct: 398 AVLMGSFGLGFVAPSAAAFTESRAAAYEIFKAIDRVPPVDI-DADGVPVTGFKQSIEFRN 456
Query: 1118 VEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDI 1297
V F+YPTR D+ + + ++L + GQ VA GSSGCGKS++I L+QRFY+P G +L D +
Sbjct: 457 VRFSYPTRPDMILFRDLNLKIKCGQKVAFSGSSGCGKSSMIGLIQRFYDPAGGAVLCDGV 516
Query: 1298 PIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTF 1477
+ + + R +G+VSQEP LF ++ +N+R G+ + ++E++ A ++AN D I +
Sbjct: 517 DMRELCLHDWRDQIGIVSQEPILFAGTMMENVRVGKPNATEEEVIEACRQANVHDTIMSL 576
Query: 1478 PEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENA 1657
P+ NT VG G Q+SGGQKQRIAIARALV+ P ILLLDEATSALD +SE VQ +L+
Sbjct: 577 PDQYNTPVGAVGSQLSGGQKQRIAIARALVKRPPILLLDEATSALDRKSEMEVQRSLDQL 636
Query: 1658 SR--GRTTIVIAHRLSTVRNADKIIVMK-----AGQVMEVGTHETLIEQKGLYHELVHAQ 1816
G T IVIAHRL+T+RN D I +K ++ E GT + L+E G + + Q
Sbjct: 637 MERGGVTVIVIAHRLATIRNVDCIYCVKYDGAEGSKIAESGTFDELMELGGEFAAMARIQ 696
Query: 1817 VFADVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDXXXXXXXXXXXXXXXXXXXXX 1996
+ D A Q R+ T + +
Sbjct: 697 GVSTGD-------ARSGARGQDGDRENDFLNMTLDEEALAHLDEEAPRTARQKVPVEELA 749
Query: 1997 XXXXXGAVKANLFKILRYARPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFS----N 2164
G V +++ + + + GA P S+ ++ V N
Sbjct: 750 KLEVNG-VNVGFRRLMEMNKDKSWAVALGILGSAVGGAARPTSSILMGYMLRVLGEYSVN 808
Query: 2165 PDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDAT 2344
+ +Q++ + +A +F++ A +G A E LT +IR ++R ++RQD
Sbjct: 809 KNVEQLRSGTNLYAPLFILFAVANFLGWALH-GFYGYAGEHLTTKIRVLLFRQIMRQDMN 867
Query: 2345 YFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVM 2524
+FD+P G + L+ D + +G + V G+ ++F Y W++A + +
Sbjct: 868 FFDIPGRDAGTLAGMLSGDCEAVHQLWGPSIGLKVQTVCIVASGVVVSFIYQWKLALVAL 927
Query: 2525 AIFPFM---AVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNI 2695
A P + ++ + +MM + + +KE + + EA+ ++RTV + ++
Sbjct: 928 ACMPLLIGCSLAERMMM-----NGYTKSKEGDTSDTIVTEALSSVRTVTSFNMKADRVEA 982
Query: 2696 FCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRV 2875
F + L ++ K II G YG I + YA F +G LI D+ + NV+
Sbjct: 983 FEATLRVEAPRSVKKGIIAGSIYGATQFIYYSAYALCFWYGSKLI-DRGE-AQFTNVMIA 1040
Query: 2876 LFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLN 3055
+I F G A ++ + A +A +F++++ P +D S +V
Sbjct: 1041 STSILFGAQNAGEAGAFATKLADAERSAKRVFSVIDRVPDVDIEQSGDKDLGKGCDVDFQ 1100
Query: 3056 KVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDN 3235
+V F Y RP +L+ +N+ G L+G +GCGKST+I +L R YD G + V+
Sbjct: 1101 RVQFIYSARPKQVVLESVNLRFGDGTVNGLMGQTGCGKSTIIQMLARFYDRRSGLICVNG 1160
Query: 3236 NDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFI 3415
DL ++ R++I++V QEP LF ++RENI Y + + T E++E A A+IH I
Sbjct: 1161 KDLSSLDIAEWRRNISVVLQEPNLFSGTVRENIRYARE--DATDEEVEEAARLAHIHWEI 1218
Query: 3416 DELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVAL 3595
+ PDGY T VG KG+ LSGGQKQR+AIAR L+R PK+LLLDEATSALD +E +VQ +
Sbjct: 1219 VKWPDGYNTEVGYKGSALSGGQKQRVAIARGLLRRPKLLLLDEATSALDNVTEAKVQEGI 1278
Query: 3596 DA--AAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAY 3742
+A A + T + +AHRL+TI + I+++ +G ++EQG+H EL+A G Y
Sbjct: 1279 NAYQAKYEVTSVSIAHRLTTIRHCDQIILLDSGHIIEQGSHEELMALGGEY 1329
Score = 287 bits (734), Expect = 2e-75
Identities = 202/590 (34%), Positives = 293/590 (49%), Gaps = 15/590 (2%)
Frame = +2
Query: 2039 ILRYA-RPEWIYXXXXXXXXLIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDG--HFWAL 2209
I RYA + + + GA MP FS F +I D M G A
Sbjct: 121 IFRYADTADRVLMIIGTIFAVCSGAGMPFFSFIFGRIAT-------DLMSGVGSVELSAA 173
Query: 2210 MFLVLAAVQGTSMLFQCS----LFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGR 2377
++ G M C + VAA R RIR +R VLRQD + D + SPG
Sbjct: 174 KTSLIMVYVGIGMFVACGGHVLCWTVAASRQERRIRLNFFRAVLRQDIGWHD--ERSPGE 231
Query: 2378 ITTRLATDAPNIKSAIDYRLGS-IFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQ 2554
+T R+ D I++ I+ +L I N + G + F + W++ +++ + PF+ V
Sbjct: 232 LTARMTGDTRVIQNGINDKLSQGIMNGAMGIIGYIA-GFVFSWELTLVMVGMMPFIIVMA 290
Query: 2555 ALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNI 2734
A++ S K AG A E +ENIRTVQ + F + I
Sbjct: 291 AIIGNIVSKMTESSRKHFAKAGSLATEVMENIRTVQVFGREDYELQRFAEAVLHAQDRGI 350
Query: 2735 SKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGF 2914
K L+ ++ + +Y AF FG +L+ + + +++ A+ +GF
Sbjct: 351 RKEFAGSLSEAVIMALVYLSYTIAFFFGSYLV--EWGRRDMADIISTFLAVLMGSFGLGF 408
Query: 2915 AASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVFFRYPERPAVP 3094
A + ++ AA IF ++ P +D ++ V F YP RP +
Sbjct: 409 VAPSAAAFTESRAAAYEIFKAIDRVPPVDIDADGVPVTGFKQSIEFRNVRFSYPTRPDMI 468
Query: 3095 ILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRK 3274
+ + LN+ +K GQ +A G SGCGKS++I L++R YDP GAV D D+R++ R
Sbjct: 469 LFRDLNLKIKCGQKVAFSGSSGCGKSSMIGLIQRFYDPAGGAVLCDGVDMRELCLHDWRD 528
Query: 3275 HIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDELPDGYETRVGE 3454
I +VSQEPILF ++ EN+ G +P T E++ AC +AN+H I LPD Y T VG
Sbjct: 529 QIGIVSQEPILFAGTMMENVRVG-KPNA-TEEEVIEACRQANVHDTIMSLPDQYNTPVGA 586
Query: 3455 KGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAK--DRTCIV 3628
G+QLSGGQKQRIAIARAL++ P ILLLDEATSALD +SE +VQ +LD + T IV
Sbjct: 587 VGSQLSGGQKQRIAIARALVKRPPILLLDEATSALDRKSEMEVQRSLDQLMERGGVTVIV 646
Query: 3629 VAHRLSTIVNAGCIMVVK-----NGQVVEQGTHNELIAKRGAYFALTQKQ 3763
+AHRL+TI N CI VK ++ E GT +EL+ G + A+ + Q
Sbjct: 647 IAHRLATIRNVDCIYCVKYDGAEGSKIAESGTFDELMELGGEFAAMARIQ 696