Homology by BLASTX
BLASTX 2.2.4 [Aug-26-2002]
Query= C48A7_2
(5634 letters)
Database: /home/niguts/usr02/tshini/ykclst/db/nr.seq
1,967,186 sequences; 661,712,633 total letters
Score E
Sequences producing significant alignments: (bits) Value
gi|21693922|gb|AAM75372.1| Egg laying defective protein 19, isof... 3332 0.0
gi|25314568|pir||C88728 protein C48A7.1 [imported] - Caenorhabdi... 3295 0.0
gi|25145845|ref|NP_741442.1| voltage-gated Calcium Channel Alpha... 3005 0.0
gi|39593582|emb|CAE61874.1| Hypothetical protein CBG05858 [Caeno... 2952 0.0
gi|45120100|ref|NP_982351.1| L-type calcium channel pore subunit... 1713 0.0
gi|32478669|gb|AAP83587.1| neuroendocrine-type voltage-gated cal... 1680 0.0
gi|21069133|gb|AAM33831.1| voltage-gated calcium channel subunit... 1660 0.0
gi|42564146|gb|AAS20587.1| L-type calcium channel pore subunit i... 1599 0.0
gi|37606176|emb|CAE50430.1| SI:zK70P6.5 (novel protein similar t... 1573 0.0
gi|27801609|emb|CAD60650.1| SI:dZ223C6.1 (novel protein similar ... 1310 0.0
gi|47229178|emb|CAG03930.1| unnamed protein product [Tetraodon n... 1263 0.0
gi|31219201|ref|XP_316767.1| ENSANGP00000001382 [Anopheles gambi... 1165 0.0
gi|29378315|gb|AAO83839.1| voltage-dependent L-type calcium chan... 1145 0.0
gi|29378313|gb|AAO83838.1| voltage-dependent L-type calcium chan... 1145 0.0
gi|31206783|ref|XP_312358.1| ENSANGP00000023154 [Anopheles gambi... 1145 0.0
gi|45554921|ref|NP_996416.1| CG1522-PF [Drosophila melanogaster]... 1144 0.0
gi|45554951|ref|NP_996418.1| CG1522-PD [Drosophila melanogaster]... 1142 0.0
gi|45554962|ref|NP_996419.1| CG1522-PC [Drosophila melanogaster]... 1139 0.0
gi|45554974|ref|NP_996420.1| CG1522-PB [Drosophila melanogaster]... 1133 0.0
gi|45554935|ref|NP_996417.1| CG1522-PE [Drosophila melanogaster]... 1132 0.0
gi|24641459|ref|NP_511133.2| CG1522-PA [Drosophila melanogaster]... 1130 0.0
gi|31206785|ref|XP_312359.1| ENSANGP00000012084 [Anopheles gambi... 1126 0.0
gi|7511817|pir||T13980 calcium channel alpha-1 chain - fruit fly... 1123 0.0
gi|30059171|gb|AAP13107.1| high voltage activated calcium channe... 1120 0.0
gi|457927|gb|AAA81883.1| calcium channel alpha-1 subunit 1112 0.0
gi|24584549|ref|NP_525104.2| CG4894-PB [Drosophila melanogaster]... 1111 0.0
gi|19584591|ref|NP_602305.1| CG4894-PA [Drosophila melanogaster]... 1110 0.0
gi|24584554|ref|NP_723953.1| CG4894-PD [Drosophila melanogaster]... 1110 0.0
gi|24584551|ref|NP_723952.1| CG4894-PC [Drosophila melanogaster]... 1096 0.0
gi|5921703|sp|Q25452|CCAM_MUSDO Muscle calcium channel alpha-1 s... 1085 0.0
gi|740990|prf||2006265A Ca channel:SUBUNIT=alpha1 1082 0.0
gi|25146677|ref|NP_741732.1| UNCoordinated locomotion UNC-2, vol... 1079 0.0
gi|25146680|ref|NP_741733.1| UNCoordinated locomotion UNC-2, vol... 1077 0.0
gi|39591060|emb|CAE58840.1| Hypothetical protein CBG02059 [Caeno... 1075 0.0
gi|25146674|ref|NP_741734.1| UNCoordinated locomotion UNC-2, vol... 1072 0.0
gi|27413155|ref|NP_083257.1| calcium channel, voltage-dependent,... 1056 0.0
gi|20338999|emb|CAD26883.1| L-type voltage-gated calcium channel... 1056 0.0
gi|8393030|ref|NP_058994.1| calcium channel, voltage-dependent, ... 1055 0.0
gi|31414559|dbj|BAC77259.1| calcium channel alpha 1D subunit [Mu... 1053 0.0
gi|4502527|ref|NP_000711.1| calcium channel, voltage-dependent, ... 1050 0.0
gi|1304105|dbj|BAA07804.1| voltage-dependent calcium channel alp... 1049 0.0
gi|6165985|sp|Q01668|CCAD_HUMAN Voltage-dependent L-type calcium... 1048 0.0
gi|87002|pir||JH0564 calcium channel alpha-1D chain - human 1048 0.0
gi|50754265|ref|XP_429273.1| PREDICTED: hypothetical protein XP_... 1047 0.0
gi|46048807|ref|NP_990365.1| L-type voltage-gated calcium channe... 1047 0.0
gi|47218490|emb|CAF97224.1| unnamed protein product [Tetraodon n... 1036 0.0
gi|116411|sp|P15381|CCAC_RABIT Voltage-dependent L-type calcium ... 1030 0.0
gi|6470279|gb|AAF13708.1| calcium channel [Oryctolagus cuniculus] 1030 0.0
gi|292275|gb|AAA02501.1| L-type voltage-dependent calcium channel 1028 0.0
gi|463073|gb|AAA51899.1| L-type voltage-dependent cardiac calciu... 1028 0.0
gi|509048|emb|CAA84347.1| voltage-dependent L-type Ca channel al... 1028 0.0
gi|463079|gb|AAA51900.1| cardiac L-type voltage-dependent calciu... 1028 0.0
gi|463082|gb|AAA51901.1| calcium channel L-type alpha 1 subunit ... 1028 0.0
gi|109169|pir||S11339 calcium channel protein - rabbit >gnl|BL_O... 1026 0.0
gi|37591134|dbj|BAA34185.2| L-type calcium channel alpha 1 subun... 1025 0.0
gi|27597080|ref|NP_000710.3| calcium channel, voltage-dependent,... 1025 0.0
gi|508183|emb|CAA84340.1| voltage-dependent L-type Ca channel al... 1025 0.0
gi|508195|emb|CAA84341.1| voltage-dependent L-type Ca channel al... 1025 0.0
gi|509068|emb|CAA84345.1| voltage-dependent L-type Ca channel al... 1025 0.0
gi|206576|gb|AAA42016.1| calcium channel alpha-1 subunit 1025 0.0
gi|17864840|gb|AAL47073.1| L-type calcium channel alpha-1c subun... 1025 0.0
gi|6753228|ref|NP_033911.1| calcium channel, voltage-dependent, ... 1025 0.0
gi|509178|emb|CAA84353.1| voltage-dependent L-type Ca channel al... 1023 0.0
gi|509168|emb|CAA84346.1| voltage-dependent L-type Ca channel al... 1023 0.0
gi|2960067|emb|CAA12174.1| voltage-dependent L-type calcium chan... 1023 0.0
gi|17864838|gb|AAL47072.1| L-type calcium channel alpha-1c subun... 1023 0.0
gi|206578|gb|AAA18905.1| calcium channel alpha-1 subunit 1021 0.0
gi|281054|pir||JH0427 voltage-dependent calcium channel complex ... 1021 0.0
gi|17864836|gb|AAL47071.1| L-type calcium channel alpha-1c subun... 1021 0.0
gi|50729014|ref|XP_416388.1| PREDICTED: similar to L-type calciu... 1020 0.0
gi|508187|emb|CAA84349.1| voltage-dependent L-type Ca channel al... 1016 0.0
gi|508199|emb|CAA84343.1| voltage-dependent L-type Ca channel al... 1016 0.0
gi|14718596|gb|AAK72959.1| voltage-gated calcium channel pore fo... 1016 0.0
gi|508191|emb|CAA84351.1| voltage-dependent L-type Ca channel al... 1015 0.0
gi|6165996|sp|Q02485|CCAS_RAT Voltage-dependent L-type calcium c... 1015 0.0
gi|18858375|ref|NP_571975.1| calcium channel, voltage-dependent,... 1014 0.0
gi|508189|emb|CAA84350.1| voltage-dependent L-type Ca channel al... 1014 0.0
gi|92951|pir||JH0422 voltage-dependent calcium channel complex a... 1014 0.0
gi|508201|emb|CAA84344.1| voltage-dependent L-type Ca channel al... 1014 0.0
gi|508197|emb|CAA84342.1| voltage-dependent L-type Ca channel al... 1014 0.0
gi|1729771|emb|CAA99284.1| voltage-dependent L-type calcium chan... 1011 0.0
gi|29789032|ref|NP_036649.1| calcium channel, voltage-dependent,... 1008 0.0
gi|33468490|emb|CAE30292.1| L-type dihydropyridine-sensitive cal... 1008 0.0
gi|89941|pir||S05011 calcium channel alpha-1 chain, dihydropyrid... 1007 0.0
gi|34933395|ref|XP_346866.1| hypothetical protein XP_346865 [Rat... 1006 0.0
gi|466355|gb|AAA17030.1| L-type calcium channel (HFCC) 1005 0.0
gi|6165981|sp|Q13936|CCAC_HUMAN Voltage-dependent L-type calcium... 1005 0.0
gi|508193|emb|CAA84352.1| voltage-dependent L-type Ca channel al... 1005 0.0
gi|284018|pir||A45290 calcium channel protein type L - human 1005 0.0
gi|4138822|gb|AAD03587.1| voltage-gated L-type calcium channel a... 1005 0.0
gi|6525019|gb|AAF15290.1| voltage-gated L-type calcium channel a... 1005 0.0
gi|4885103|ref|NP_005174.1| calcium channel, voltage-dependent, ... 1005 0.0
gi|9624973|ref|NP_062528.1| calcium channel, voltage-dependent, ... 1003 0.0
gi|164761|gb|AAA31159.1| dihydropyridine calcium channel recepto... 1003 0.0
gi|116408|sp|P07293|CCAS_RABIT Voltage-dependent L-type calcium ... 1003 0.0
gi|16758518|ref|NP_446153.1| calcium channel, voltage-dependent,... 1002 0.0
gi|6751840|dbj|BAA34927.2| ascidian calcium channel alpha1-subun... 999 0.0
gi|7512118|pir||T30890 calcium channel alpha1-chain - sea squirt... 999 0.0
gi|691720|gb|AAA62612.1| murine erythroleukemia cardiac calcium ... 986 0.0
gi|4557401|ref|NP_000060.1| calcium channel, voltage-dependent, ... 986 0.0
gi|6165995|sp|Q13698|CCAS_HUMAN Voltage-dependent L-type calcium... 985 0.0
gi|48094843|ref|XP_394283.1| similar to calcium channel, voltage... 980 0.0
gi|46576355|sp|O57483|CCAS_RANCA Voltage-dependent L-type calciu... 971 0.0
gi|11279259|pir||T43262 calcium channel alpha-1 chain, L-type - ... 970 0.0
gi|7508712|pir||T16779 hypothetical protein unc-2 - Caenorhabdit... 969 0.0
gi|736714|dbj|BAA07283.1| L-type voltage-dependent calcium chann... 967 0.0
gi|1698403|gb|AAB37235.1| dihydropyridine receptor alpha 1 subunit 964 0.0
gi|15131669|emb|CAC48390.1| voltage-gated calcium channel alpha1... 962 0.0
gi|6165986|sp|Q99244|CCAD_MESAU Voltage-dependent L-type calcium... 962 0.0
gi|1588292|prf||2208308A Ca channel:SUBUNIT=alpha:ISOTYPE=L 960 0.0
gi|50761288|ref|XP_419259.1| PREDICTED: similar to Voltage-depen... 935 0.0
gi|31236903|ref|XP_319498.1| ENSANGP00000002951 [Anopheles gambi... 928 0.0
gi|2373389|dbj|BAA22091.1| voltage-dependent calcium channel alp... 926 0.0
gi|47550741|ref|NP_999891.1| skeletal muscle L-type calcium chan... 918 0.0
gi|7521913|pir||T30535 calcium channel alpha-1 chain homolog - F... 910 0.0
gi|508185|emb|CAA84348.1| voltage-dependent L-type Ca channel al... 909 0.0
gi|116407|sp|P22316|CCAS_CYPCA Dihydropyridine-sensitive L-type,... 904 0.0
gi|11279256|pir||T43048 calcium channel alpha-1 chain - Cyanea c... 899 0.0
gi|15127838|gb|AAK84312.1| high voltage-activated calcium channe... 889 0.0
gi|47228705|emb|CAG07437.1| unnamed protein product [Tetraodon n... 867 0.0
gi|38073276|ref|XP_358335.1| calcium channel, voltage-dependent,... 852 0.0
gi|48095459|ref|XP_392298.1| similar to ENSANGP00000023154 [Apis... 822 0.0
gi|47207166|emb|CAG06208.1| unnamed protein product [Tetraodon n... 804 0.0
gi|2133450|pir||S58883 calcium-channel homolog - Caenorhabditis ... 794 0.0
gi|47220469|emb|CAG03249.1| unnamed protein product [Tetraodon n... 778 0.0
gi|509344|emb|CAA81219.1| L-type Ca2+ channel isoform 1, neurona... 759 0.0
gi|22204436|emb|CAD43424.1| SI:dZ136D19.3 (novel protein similar... 735 0.0
gi|7209876|dbj|BAA13136.2| voltage-dependent calcium channel [Lo... 697 0.0
gi|7447633|pir||JC5280 voltage-dependent calcium channel alpha 1... 693 0.0
gi|31206787|ref|XP_312360.1| ENSANGP00000012088 [Anopheles gambi... 691 0.0
gi|29378319|gb|AAO83841.1| voltage-dependent non-L-type calcium ... 687 0.0
gi|6978579|ref|NP_037050.1| calcium channel, voltage-dependent, ... 683 0.0
gi|5802901|gb|AAD51822.1| N-type calcium channel alpha-1B cdB8 v... 679 0.0
gi|5802891|gb|AAD51817.1| N-type calcium channel alpha-1B cdB3 v... 679 0.0
gi|5802889|gb|AAD51816.1| N-type calcium channel alpha-1B cdB2 v... 679 0.0
gi|45383554|ref|NP_989624.1| calcium channel, voltage-dependent,... 679 0.0
gi|5802895|gb|AAD51819.1| N-type calcium channel alpha-1B cdB5 v... 679 0.0
gi|5802897|gb|AAD51820.1| N-type calcium channel alpha-1B cdB6 v... 679 0.0
gi|5802893|gb|AAD51818.1| N-type calcium channel alpha-1B cdB4 v... 679 0.0
gi|5802899|gb|AAD51821.1| N-type calcium channel alpha-1B cdB7 v... 679 0.0
gi|13386500|ref|NP_000059.2| calcium channel, alpha 1A subunit i... 679 0.0
gi|13386498|ref|NP_075461.1| calcium channel, alpha 1A subunit i... 679 0.0
gi|18958263|dbj|BAB85612.1| CaV2.1 [Mus musculus] 677 0.0
gi|18958261|dbj|BAB85611.1| CaV2.1 [Mus musculus] 677 0.0
gi|1657333|emb|CAA68172.1| calcium channel alpha1 subunit [Homo ... 676 0.0
gi|2136950|pir||I46480 calcium channel BI-2 - rabbit >gnl|BL_ORD... 676 0.0
gi|1525|emb|CAA40871.1| calcium channel BI-1 [Oryctolagus cunicu... 676 0.0
gi|192324|gb|AAB59700.1| dihydropyridine sensitive calcium channel 676 0.0
gi|29378321|gb|AAO83842.1| voltage-dependent non-L-type calcium ... 676 0.0
gi|6680820|ref|NP_031604.1| calcium channel, voltage-dependent, ... 675 0.0
gi|7159258|gb|AAF37688.1| calcium channel alpha1E subunit, delta... 672 0.0
gi|27807135|ref|NP_777057.1| calcium channel, voltage-dependent,... 671 0.0
gi|6166047|sp|O00555|CCAA_HUMAN Voltage-dependent P/Q-type calci... 670 0.0
gi|9711929|dbj|BAA94766.2| alpha1A-voltage-dependent calcium cha... 670 0.0
gi|2213913|gb|AAB61613.1| neuronal calcium channel alpha 1A subu... 668 0.0
gi|2213911|gb|AAB61612.1| neuronal calcium channel alpha 1A subu... 668 0.0
gi|25453410|ref|NP_671482.1| calcium channel, voltage-dependent,... 667 0.0
gi|7630181|dbj|BAA94765.1| alpha1A-voltage-dependent calcium cha... 667 0.0
gi|6166049|sp|O55017|CCAB_MOUSE Voltage-dependent N-type calcium... 667 0.0
gi|11279258|pir||T45115 N-type calcium channel alpha-1 chain, om... 665 0.0
gi|284339|pir||A42566 omega-conotoxin-sensitive N-type calcium c... 665 0.0
gi|4502523|ref|NP_000709.1| calcium channel, voltage-dependent, ... 665 0.0
gi|1705855|sp|Q02294|CCAB_RAT Voltage-dependent N-type calcium c... 665 0.0
gi|29789098|ref|NP_062167.1| calcium channel, voltage-dependent,... 664 0.0
gi|6753230|ref|NP_033912.1| calcium channel, voltage-dependent, ... 664 0.0
gi|5921693|sp|Q05152|CCAB_RABIT Voltage-dependent N-type calcium... 664 0.0
gi|14578563|gb|AAK33009.1| calcium channel isoform alpha1E7 [Rat... 664 0.0
gi|5921456|sp|P56698|CCAB_DISOM Probable voltage-dependent N-typ... 663 0.0
gi|227711|prf||1709354B voltage dependent Ca channel BI-2 663 0.0
gi|399201|sp|P27884|CCAA_RABIT Voltage-dependent P/Q-type calciu... 663 0.0
gi|2136947|pir||I46477 calcium channel BI-1 - rabbit >gnl|BL_ORD... 663 0.0
gi|227710|prf||1709354A voltage dependent Ca channel BI-1 663 0.0
gi|6165988|sp|Q15878|CCAE_HUMAN Voltage-dependent R-type calcium... 663 0.0
gi|4502529|ref|NP_000712.1| calcium channel, voltage-dependent, ... 663 0.0
gi|7159257|gb|AAF37687.1| calcium channel alpha1E subunit, delta... 663 0.0
gi|1082919|pir||A54972 voltage-dependent calcium channel alpha 1... 663 0.0
gi|478761|pir||S29237 calcium channel protein BII-2, brain - rab... 660 0.0
gi|399202|sp|Q02343|CCAE_RABIT Voltage-dependent R-type calcium ... 660 0.0
gi|348579|pir||A45386 omega-conotoxin-sensitive calcium channel ... 660 0.0
gi|5921698|sp|P56699|CCAE_DISOM Probable voltage-dependent R-typ... 657 0.0
gi|32478671|gb|AAP83588.1| neuronal-type voltage-gated calcium c... 646 0.0
gi|30794964|gb|AAP40629.1| voltage-gated calcium channel subunit... 646 0.0
gi|30794966|gb|AAP40630.1| voltage-gated calcium channel subunit... 646 0.0
gi|6680822|ref|NP_031605.1| calcium channel, voltage-dependent, ... 644 0.0
gi|15127836|gb|AAK84311.1| high voltage-activated calcium channe... 641 0.0
gi|631650|pir||S41080 calcium channel alpha-1 chain - mouse 640 0.0
gi|47225650|emb|CAG07993.1| unnamed protein product [Tetraodon n... 638 0.0
gi|15127840|gb|AAK84313.1| high voltage-activated calcium channe... 626 e-177
gi|47218489|emb|CAF97223.1| unnamed protein product [Tetraodon n... 619 e-175
gi|50751098|ref|XP_422255.1| PREDICTED: similar to calcium chann... 606 e-171
gi|6180177|gb|AAF05830.1| L-type calcium channel alpha-1 subunit... 585 e-165
gi|27752873|gb|AAO19446.1| L-type Ca channel alpha 1 subunit [Ca... 584 e-165
gi|2707602|gb|AAB92359.1| calcium channel alpha-1 subunit [Homo ... 582 e-164
gi|1763630|gb|AAB49675.1| alpha1A-voltage-dependent calcium chan... 578 e-163
gi|47229683|emb|CAG06879.1| unnamed protein product [Tetraodon n... 577 e-162
gi|1763632|gb|AAB49676.1| alpha1A-voltage-sensitive calcium chan... 568 e-160
gi|1763628|gb|AAB49674.1| alpha1A-voltage-dependent calcium chan... 568 e-160
gi|1763638|gb|AAB49678.1| alpha1A-voltage-dependent calcium chan... 567 e-159
gi|1763636|gb|AAB49677.1| alpha1A-voltage-dependent calcium chan... 567 e-159
gi|37590154|gb|AAH58783.1| Unknown (protein for MGC:65542) [Mus ... 551 e-155
gi|509341|emb|CAA81218.1| L-type Ca2+ channel isoform 1, neurona... 541 e-152
gi|47211821|emb|CAG02277.1| unnamed protein product [Tetraodon n... 502 e-140
gi|47220372|emb|CAF98471.1| unnamed protein product [Tetraodon n... 486 e-135
gi|3873285|gb|AAC77460.1| voltage-dependent P/Q type calcium cha... 464 e-128
gi|29378317|gb|AAO83840.1| voltage-dependent L-type calcium chan... 461 e-127
gi|26336709|dbj|BAC32037.1| unnamed protein product [Mus musculus] 449 e-124
gi|47213887|emb|CAF93569.1| unnamed protein product [Tetraodon n... 443 e-122
gi|47215104|emb|CAF98178.1| unnamed protein product [Tetraodon n... 423 e-116
gi|109175|pir||S12955 calcium channel protein type L - rabbit >g... 382 e-104
gi|20302749|gb|AAM18875.1| unknown [Branchiostoma floridae] 376 e-102
gi|191325|gb|AAA62807.1| neuroendocrine L-type calcium channel 368 1e-99
gi|5921697|sp|Q99246|CCAD_MOUSE Voltage-dependent L-type calcium... 368 1e-99
gi|974296|gb|AAA89156.1| calcium channel alpha-1D subunit 366 3e-99
gi|974298|gb|AAA89157.1| calcium channel alpha-1C subunit 365 7e-99
gi|191323|gb|AAB59702.1| neuroendocrine L-type calcium channel 363 3e-98
gi|46406278|emb|CAF18236.1| voltage-gated calcium channel alpha ... 362 4e-98
gi|105517|pir||C23660 calcium channel protein 3 - human (fragment) 358 6e-97
gi|192318|gb|AAA63291.1| cardiac L-type calcium channel 358 6e-97
gi|105515|pir||A23660 calcium channel protein 1 - human (fragmen... 358 6e-97
gi|2961610|gb|AAC24516.1| class A calcium channel variant riA-I ... 358 1e-96
gi|164838|gb|AAA31182.1| cardiac L-type calcium channel 357 2e-96
gi|105516|pir||B23660 calcium channel protein 2 - human (fragmen... 356 3e-96
gi|5921704|sp|O42398|CCAS_CHICK Voltage-dependent L-type calcium... 353 2e-95
gi|16182450|gb|AAL13497.1| GH02029p [Drosophila melanogaster] 352 8e-95
gi|974300|gb|AAA89158.1| calcium channel alpha-1S subunit 351 1e-94
gi|2213641|gb|AAB61636.1| calcium channel alpha-1 subunit [Rattu... 349 4e-94
gi|192316|gb|AAA63290.1| L-type calcium channel 347 1e-93
gi|203371|gb|AAA40895.1| calcium channel alpha-1 subunit 342 5e-92
gi|192314|gb|AAA03684.1| skeletal muscle L-type calcium channel 342 8e-92
gi|47214907|emb|CAG04101.1| unnamed protein product [Tetraodon n... 336 4e-90
gi|2373391|dbj|BAA22092.1| voltage-dependent calcium channel alp... 333 2e-89
gi|14718598|gb|AAK72960.1| voltage-gated calcium channel pore fo... 328 1e-87
gi|3329353|gb|AAC26839.1| CACNL1A4; neuronal calcium channel alp... 322 5e-86
gi|29420815|dbj|BAC66629.1| L-type calcium channel alpha 1c subu... 322 7e-86
gi|2213639|gb|AAB61635.1| calcium channel alpha-1 subunit [Rattu... 310 3e-82
gi|19525676|gb|AAL89642.1| voltage-gated calcium channel alpha-1... 307 2e-81
gi|92040|pir||S05006 calcium channel alpha-1 chain, dihydropyrid... 298 1e-78
gi|2454166|gb|AAB71618.1| calcium channel alpha-1 subunit 296 5e-78
gi|24640054|ref|NP_572296.1| CG15899-PB [Drosophila melanogaster... 282 6e-74
gi|4506813|ref|NP_002968.1| sodium channel, voltage-gated, type ... 279 5e-73
gi|31206935|ref|XP_312434.1| ENSANGP00000003024 [Anopheles gambi... 279 5e-73
gi|50729246|ref|XP_425474.1| PREDICTED: similar to voltage-depen... 278 8e-73
gi|1022714|gb|AAA89159.1| sodium channel alpha-subunit 278 1e-72
gi|34872708|ref|XP_346403.1| hypothetical protein XP_346402 [Rat... 278 1e-72
gi|17129560|emb|CAD12646.1| calcium channel, voltage-dependent, ... 278 1e-72
gi|38505286|ref|NP_938200.1| voltage-dependent calcium channel a... 277 2e-72
gi|38505290|ref|NP_938202.1| voltage-dependent calcium channel a... 277 2e-72
gi|20521770|dbj|BAA86437.2| KIAA1123 protein [Homo sapiens] 277 2e-72
gi|24429576|ref|NP_113789.2| calcium channel, voltage-dependent,... 277 2e-72
gi|21717818|ref|NP_064469.2| calcium channel, voltage-dependent,... 276 3e-72
gi|34866777|ref|XP_346807.1| hypothetical protein XP_346806 [Rat... 276 3e-72
gi|14336738|gb|AAK61268.1| voltage dependent t-type calcium chan... 276 5e-72
gi|14670397|gb|AAC67239.3| T-type calcium channel alpha 1H subun... 276 5e-72
gi|10864077|ref|NP_066921.1| calcium channel, voltage-dependent,... 276 5e-72
gi|23503045|sp|O95180|CCAH_HUMAN Voltage-dependent T-type calciu... 276 5e-72
gi|7330235|gb|AAF60163.1| low-voltage-activated calcium channel ... 276 5e-72
gi|29378323|gb|AAO83843.1| voltage-dependent T-type calcium chan... 276 5e-72
gi|6572191|emb|CAB62996.1| dJ172B20.1 (calcium channel, voltage-... 275 7e-72
gi|38505272|ref|NP_938192.1| voltage-dependent calcium channel a... 275 7e-72
gi|7021531|gb|AAF35390.1| voltage-gated sodium channel alpha sub... 275 7e-72
gi|31616072|emb|CAD92537.1| dJ172B20.1 (calcium channel, voltage... 275 7e-72
gi|38505274|ref|NP_938193.1| voltage-dependent calcium channel a... 275 7e-72
gi|22796540|emb|CAD10507.1| voltage-gated sodium channel [Homo s... 275 7e-72
gi|7657542|ref|NP_054858.1| sodium channel, voltage-gated, type ... 275 7e-72
gi|6572950|gb|AAF17480.1| voltage-gated sodium channel type XI a... 275 7e-72
gi|7271791|gb|AAF44626.1| T-type calcium channel alpha1 subunit ... 275 7e-72
gi|38505288|ref|NP_938201.1| voltage-dependent calcium channel a... 275 7e-72
gi|5565888|gb|AAD45251.1| T-type calcium channel alpha1I subunit... 275 7e-72
gi|21361077|ref|NP_066919.2| calcium channel, voltage-dependent,... 275 7e-72
gi|6981510|ref|NP_037251.1| sodium channel, voltage-gated, type ... 275 7e-72
gi|38505292|ref|NP_938406.1| voltage-dependent calcium channel a... 275 7e-72
gi|38505268|ref|NP_938190.1| voltage-dependent calcium channel a... 275 7e-72
gi|38505276|ref|NP_938194.1| voltage-dependent calcium channel a... 275 7e-72
gi|31616071|emb|CAD92536.1| dJ172B20.1 (calcium channel, voltage... 275 7e-72
gi|21622605|gb|AAM67414.1| voltage-dependent calcium channel T-t... 275 7e-72
gi|281042|pir||A60054 sodium channel protein IIIb, long form - rat 275 7e-72
gi|47218637|emb|CAG04966.1| unnamed protein product [Tetraodon n... 275 9e-72
gi|729137|sp|Q05973|CIN1_LOLBL Sodium channel protein I, brain >... 275 1e-71
gi|11415020|gb|AAG35188.1| calcium channel alpha-1-I subunit [Ra... 274 2e-71
gi|951126|gb|AAC52242.1| SCN8A >gnl|BL_ORD_ID|579467 gi|1586351|... 274 2e-71
gi|6755410|ref|NP_035453.1| sodium channel, voltage-gated, type ... 274 2e-71
gi|7657544|ref|NP_055006.1| sodium channel, voltage gated, type ... 274 2e-71
gi|4321647|gb|AAD15789.1| voltage-gated sodium channel alpha sub... 273 3e-71
gi|4633670|gb|AAD26858.1| T-type calcium channel isoform [Rattus... 273 4e-71
gi|8096345|dbj|BAA95896.1| sodium channel [Halocynthia roretzi] 273 5e-71
gi|3309113|gb|AAC26014.1| voltage-gated sodium channel rPN4 [Rat... 273 5e-71
gi|9507067|ref|NP_062139.1| sodium channel, voltage-gated, type ... 273 5e-71
gi|28972636|dbj|BAC65734.1| mKIAA1120 protein [Mus musculus] 272 8e-71
gi|25014054|sp|Q9NY46|CIN3_HUMAN Sodium channel protein type III... 272 8e-71
gi|20532014|sp|Q9EQ60|CCAH_RAT Voltage-dependent T-type calcium ... 272 8e-71
gi|12382858|gb|AAG53415.1| voltage-gated sodium channel type III... 272 8e-71
gi|7414320|emb|CAB85895.1| type III sodium channel protein [Homo... 272 8e-71
gi|92753|pir||B25019 sodium channel protein II - rat >gnl|BL_ORD... 271 1e-70
gi|6981506|ref|NP_036779.1| sodium channel, voltage-gated, type ... 271 1e-70
gi|47226379|emb|CAG09347.1| unnamed protein product [Tetraodon n... 271 1e-70
gi|2119594|pir||I56555 sodium channel protein 6 - rat >gnl|BL_OR... 271 1e-70
gi|38505284|ref|NP_938199.1| voltage-dependent calcium channel a... 271 2e-70
gi|37360252|dbj|BAC98104.1| mKIAA1123 protein [Mus musculus] 271 2e-70
gi|38505270|ref|NP_938191.1| voltage-dependent calcium channel a... 271 2e-70
gi|38505278|ref|NP_938196.1| voltage-dependent calcium channel a... 271 2e-70
gi|38505282|ref|NP_938198.1| voltage-dependent calcium channel a... 271 2e-70
gi|34783701|gb|AAH57399.1| Cacna1g protein [Mus musculus] 271 2e-70
gi|38505280|ref|NP_938197.1| voltage-dependent calcium channel a... 271 2e-70
gi|20070163|ref|NP_061496.2| voltage-dependent calcium channel a... 271 2e-70
gi|12382816|gb|AAG53412.1| voltage-gated sodium channel type II ... 270 2e-70
gi|10337597|ref|NP_066287.1| sodium channel, voltage-gated, type... 270 2e-70
gi|25014053|sp|Q99250|CIN2_HUMAN Sodium channel protein type II ... 270 2e-70
gi|476881|pir||A46269 sodium channel alpha chain HBA - human 270 3e-70
gi|1657984|gb|AAC47483.1| para sodium channel [Blattella germanica] 270 4e-70
gi|1657986|gb|AAC47484.1| para sodium channel [Blattella germanica] 270 4e-70
gi|2143635|pir||I60902 calcium channel alpha-1 subunit - rat (fr... 270 4e-70
gi|31228855|ref|XP_318122.1| ENSANGP00000024823 [Anopheles gambi... 270 4e-70
gi|1783373|gb|AAB47604.1| voltage-sensitive sodium channel 269 5e-70
gi|1842214|gb|AAB47605.1| voltage-sensitive sodium channel 269 5e-70
gi|7441675|pir||S72458 sodium channel protein para-type alpha ch... 269 5e-70
gi|50080866|gb|AAT69681.1| voltage-dependent para-like sodium ch... 269 7e-70
gi|50080864|gb|AAT69680.1| voltage-dependent para-like sodium ch... 269 7e-70
gi|13435399|ref|NP_067390.2| calcium channel alpha13.2 subunit [... 268 9e-70
gi|18959222|ref|NP_579823.1| sodium channel 25; sodium channel, ... 268 9e-70
gi|29467444|dbj|BAC67159.1| para-orthologous sodium channel alph... 268 1e-69
gi|7441677|pir||S72467 sodium channel protein para-type alpha ch... 268 1e-69
gi|30350266|gb|AAP20108.1| voltage-sensitive sodium channel alph... 268 1e-69
gi|30350264|gb|AAP20107.1| voltage-sensitive sodium channel alph... 268 1e-69
gi|30350262|gb|AAP20106.1| voltage-sensitive sodium channel alph... 268 1e-69
gi|4325288|gb|AAD17315.1| voltage-dependent sodium channel [Cyno... 268 1e-69
gi|6753232|ref|NP_033913.1| calcium channel, voltage-dependent, ... 267 2e-69
gi|7522130|pir||T31092 probable voltage-gated sodium channel - A... 267 2e-69
gi|50750497|ref|XP_422021.1| PREDICTED: similar to voltage-gated... 267 2e-69
gi|2119597|pir||I54323 sodium channel alpha subunit - human >gnl... 266 3e-69
gi|19923381|ref|NP_008853.2| sodium channel, voltage-gated, type... 266 4e-69
gi|12642272|gb|AAK00218.1| voltage-gated sodium channel alpha su... 266 4e-69
gi|24642537|ref|NP_523371.2| CG9907-PA [Drosophila melanogaster]... 266 6e-69
gi|403444|gb|AAB59192.1| sodium channel alpha subunit [Drosophil... 265 7e-69
gi|403445|gb|AAB59193.1| sodium channel alpha subunit [Drosophil... 265 7e-69
gi|50760568|ref|XP_418062.1| PREDICTED: similar to sodium channe... 265 7e-69
gi|403442|gb|AAB59190.1| sodium channel alpha subunit [Drosophil... 265 7e-69
gi|403446|gb|AAB59194.1| sodium channel alpha subunit [Drosophil... 265 7e-69
gi|403443|gb|AAB59191.1| sodium channel alpha subunit [Drosophil... 265 7e-69
gi|544038|sp|P35500|CINA_DROME Sodium channel protein para (Para... 265 7e-69
gi|24762775|ref|NP_726495.1| CG9071-PB [Drosophila melanogaster]... 265 1e-68
gi|13540709|ref|NP_110502.1| sodium channel, voltage-gated, type... 265 1e-68
gi|28573635|ref|NP_523858.5| CG9071-PA [Drosophila melanogaster]... 265 1e-68
gi|3320596|gb|AAC26513.1| voltage-gated sodium channel alpha sub... 264 2e-68
gi|23978418|dbj|BAC21101.1| voltage-gated sodium channel alpha1 ... 263 3e-68
gi|12644229|sp|P35498|CIN1_HUMAN Sodium channel protein type I a... 263 3e-68
gi|27263190|dbj|BAC45228.1| Voltage-gated sodium channel alpha 1... 263 3e-68
gi|29893559|ref|NP_008851.2| sodium channel, voltage-gated, type... 263 3e-68
gi|12642270|gb|AAK00217.1| voltage-gated sodium channel alpha su... 263 3e-68
gi|11277047|pir||T43167 sodium channel protein - California mark... 263 4e-68
gi|243989|gb|AAB21221.1| sodium channel alpha subunit [human, sk... 263 5e-68
gi|40255316|ref|NP_000325.3| sodium channel, voltage-gated, type... 263 5e-68
gi|88616|pir||JS0648 sodium channel alpha chain - human 263 5e-68
gi|44889019|sp|P35499|CIN4_HUMAN Sodium channel protein type IV ... 263 5e-68
gi|31788956|gb|AAO83647.1| skeletal muscle voltage-dependent sod... 262 6e-68
gi|994814|gb|AAA75572.1| sodium channel 262 6e-68
gi|2119592|pir||I51964 sodium channel alpha chain SCN4A, skeleta... 262 8e-68
gi|543687|pir||A48298 sodium channel homolog - jellyfish (Cyanea... 262 8e-68
gi|531237|dbj|BAA07195.1| sodium channel alpha subunit [Takifugu... 261 1e-67
gi|30142161|gb|AAP13992.1| sodium channel protein [Varroa destru... 261 1e-67
gi|14547893|ref|NP_067519.1| voltage-gated sodium channel type V... 261 2e-67
gi|6981514|ref|NP_037257.1| voltage-gated sodium channel type V ... 261 2e-67
gi|13774490|gb|AAK38884.1| sodium channel Nav1.5a [Rattus norveg... 261 2e-67
gi|34854632|ref|XP_346658.1| hypothetical protein XP_346657 [Rat... 261 2e-67
gi|12658323|gb|AAK01090.1| putative BSC1 sodium channel protein ... 260 2e-67
gi|6677875|ref|NP_033160.1| sodium channel, voltage-gated, type ... 259 4e-67
gi|6981512|ref|NP_037310.1| sodium channel, voltage-gated, type ... 259 4e-67
gi|27806135|ref|NP_776883.1| sodium channel, voltage-gated, type... 259 5e-67
gi|3087876|emb|CAA76659.1| rat skeletal muscle type 1 voltage-ga... 258 9e-67
gi|18875344|ref|NP_573462.1| sodium channel, voltage-gated, type... 258 9e-67
gi|26324133|gb|AAN77378.1| L-type calcium channel alpha subunit ... 258 1e-66
gi|31199447|ref|XP_308671.1| ENSANGP00000023264 [Anopheles gambi... 257 2e-66
gi|7522168|pir||T31340 voltage-gated sodium channel homolog - Bd... 257 2e-66
gi|47219643|emb|CAG02688.1| unnamed protein product [Tetraodon n... 256 3e-66
gi|48096939|ref|XP_392548.1| similar to para sodium channel [Api... 256 3e-66
gi|4755118|gb|AAD23600.2| putative sodium channel [Boophilus mic... 256 4e-66
gi|29691680|emb|CAD88248.1| voltage-gated sodium channel alpha s... 255 8e-66
gi|29569618|gb|AAO91669.1| cardiac sodium channel alpha subunit ... 255 1e-65
gi|15072487|gb|AAK74065.1| voltage-gated sodium channel type V a... 255 1e-65
gi|30089970|ref|NP_000326.2| voltage-gated sodium channel type V... 255 1e-65
gi|37622907|ref|NP_932173.1| voltage-gated sodium channel type V... 255 1e-65
gi|4033376|sp|Q14524|CIN5_HUMAN Sodium channel protein type V al... 255 1e-65
gi|44886084|dbj|BAD12085.1| TTX-resistant sodium channel splicin... 254 1e-65
gi|8394242|ref|NP_058943.1| sodium channel, voltage-gated, type ... 254 1e-65
gi|47220627|emb|CAG06549.1| unnamed protein product [Tetraodon n... 254 1e-65
gi|34866602|ref|XP_346841.1| hypothetical protein XP_346840 [Rat... 254 1e-65
gi|1586352|prf||2203418A voltage-gated Na channel 254 1e-65
gi|44886082|dbj|BAD12084.1| TTX-resistant sodium channel [Homo s... 254 1e-65
gi|7441678|pir||JE0084 voltage-gated sodium channel alpha subuni... 254 1e-65
gi|47214918|emb|CAG04112.1| unnamed protein product [Tetraodon n... 254 2e-65
gi|47228731|emb|CAG07463.1| unnamed protein product [Tetraodon n... 254 2e-65
gi|6815119|dbj|BAA90398.1| voltage-gated sodium channel [Takifug... 253 3e-65
gi|24371298|ref|NP_571703.1| sodium channel, voltage-gated, type... 253 5e-65
gi|42768804|gb|AAS45602.1| tetrodotoxin resistant sodium channel... 251 1e-64
gi|11277046|pir||T43161 sodium channel protein TuNaI - sea squir... 251 1e-64
gi|31982749|ref|NP_036017.2| sodium channel, voltage-gated, type... 251 1e-64
gi|5730033|ref|NP_006505.1| sodium channel, voltage-gated, type ... 251 1e-64
gi|7511719|pir||T30902 sodium channel SCAP1 alpha chain - Califo... 250 2e-64
gi|50732221|ref|XP_418535.1| PREDICTED: similar to voltage-gated... 249 4e-64
gi|25146601|ref|NP_741848.1| voltage-gated Calcium Channel Alpha... 249 7e-64
gi|32481968|gb|AAP84337.1| T-type voltage sensitive calcium chan... 249 7e-64
gi|32330671|gb|AAP79882.1| T-type calcium channel alpha1 subunit... 249 7e-64
gi|47210106|emb|CAF93432.1| unnamed protein product [Tetraodon n... 249 7e-64
gi|9507065|ref|NP_062138.1| sodium channel, voltage-gated, type1... 248 2e-63
gi|5833120|gb|AAD53403.1| voltage-gated sodium channel NaN [Mus ... 248 2e-63
gi|829615|gb|AAA67366.1| skeletal muscle sodium channel alpha-su... 246 4e-63
gi|47217306|emb|CAG12514.1| unnamed protein product [Tetraodon n... 245 8e-63
gi|280619|pir||A60165 sodium channel protein - fruit fly (Drosop... 245 8e-63
gi|32330673|gb|AAP79883.1| T-type calcium channel alpha1 subunit... 245 1e-62
gi|2760341|gb|AAC39164.1| TTX-resistant sodium channel [Canis fa... 245 1e-62
gi|116451|sp|P02719|CINA_ELEEL Sodium channel protein (Na(+) cha... 245 1e-62
gi|103395|pir||A33299 sodium channel protein - fruit fly (Drosop... 244 1e-62
gi|6329715|dbj|BAA86434.1| KIAA1120 protein [Homo sapiens] 244 1e-62
gi|23630517|gb|AAN37408.1| sodium channel [Varroa destructor] 244 2e-62
gi|13936539|gb|AAK49820.1| calcium channel subunit alpha 1D [Bos... 242 9e-62
gi|47228044|emb|CAF97673.1| unnamed protein product [Tetraodon n... 241 1e-61
gi|38074787|ref|XP_141278.3| similar to sodium channel protein I... 240 3e-61
gi|951207|gb|AAA74590.1| voltage-gated calcium channel 240 3e-61
gi|423146|pir||A44363 voltage-gated dihydropyridine-sensitive ca... 237 3e-60
gi|192322|gb|AAA37351.1| dihydropyridine sensitive calcium channel 236 4e-60
gi|92039|pir||S05007 calcium channel alpha-1 chain, dihydropyrid... 235 1e-59
gi|48101399|ref|XP_395121.1| similar to putative BSC1 sodium cha... 234 1e-59
gi|5921695|sp|O73707|CCAC_CHICK Voltage-dependent L-type calcium... 234 2e-59
gi|31199445|ref|XP_308670.1| ENSANGP00000011132 [Anopheles gambi... 233 5e-59
gi|38074783|ref|XP_141275.4| similar to Sodium channel protein t... 231 2e-58
gi|19525675|gb|AAL89641.1| voltage-gated calcium channel alpha-1... 231 2e-58
gi|50806677|ref|XP_424477.1| PREDICTED: similar to sodium channe... 230 3e-58
gi|19525674|gb|AAL89640.1| voltage-gated calcium channel alpha-1... 230 3e-58
gi|262189|gb|AAB24611.1| neuronal-type voltage-gated Ca2+ channe... 229 4e-58
gi|39594202|emb|CAE70312.1| Hypothetical protein CBG16834 [Caeno... 226 4e-57
gi|10178619|gb|AAG13654.1| calcium channel subunit alpha 1E [Bos... 218 1e-54
gi|50732629|ref|XP_425965.1| PREDICTED: similar to sodium channe... 218 1e-54
gi|47206534|emb|CAF90965.1| unnamed protein product [Tetraodon n... 218 2e-54
gi|31228860|ref|XP_318123.1| ENSANGP00000017530 [Anopheles gambi... 217 2e-54
gi|6003538|gb|AAF00491.1| calcium channel alpha-1 subunit [Bdell... 217 3e-54
gi|50755633|ref|XP_414830.1| PREDICTED: similar to voltage-depen... 208 1e-51
gi|33469089|ref|NP_033161.1| sodium channel, voltage-gated, type... 206 5e-51
gi|47214563|emb|CAF96236.1| unnamed protein product [Tetraodon n... 206 7e-51
gi|46406282|emb|CAF18238.1| voltage-gated calcium channel alpha ... 201 2e-49
gi|25742828|ref|NP_113874.1| sodium channel, voltage-gated, type... 199 8e-49
gi|13936533|gb|AAK49817.1| calcium channel subunit alpha 1A [Bos... 197 3e-48
gi|46406284|emb|CAF18239.1| voltage-gated calcium channel alpha ... 197 3e-48
gi|5921455|sp|O73706|CCAB_CHICK Voltage-dependent N-type calcium... 196 7e-48
gi|26342821|dbj|BAC35067.1| unnamed protein product [Mus musculus] 194 2e-47
gi|46406280|emb|CAF18237.1| voltage-gated calcium channel alpha ... 193 5e-47
gi|4506811|ref|NP_002967.1| sodium channel, voltage-gated, type ... 192 6e-47
gi|50811648|ref|XP_426722.1| PREDICTED: similar to calcium chann... 192 6e-47
gi|7497922|pir||T15838 hypothetical protein C54D2.5 - Caenorhabd... 189 5e-46
gi|2213637|gb|AAB61634.1| calcium channel alpha-1 subunit [Rattu... 187 3e-45
gi|5921452|sp|O73705|CCAA_CHICK Voltage-dependent P/Q-type calci... 186 4e-45
gi|111449|pir||B35901 calcium channel protein alpha-1 chain, dih... 184 2e-44
gi|5921694|sp|O35505|CCAC_CAVPO Voltage-dependent L-type calcium... 183 4e-44
gi|39752858|gb|AAR30210.1| Calcium channel, alpha subunit protei... 176 8e-42
gi|21392682|gb|AAM51535.1| Calcium channel, alpha subunit protei... 176 8e-42
gi|6693705|gb|AAF24980.1| voltage-gated sodium channel alpha sub... 175 1e-41
gi|21428788|gb|AAM50113.1| GH02471p [Drosophila melanogaster] 174 2e-41
gi|45454398|gb|AAS65873.1| four domain-type voltage-gated ion ch... 174 2e-41
gi|24119274|ref|NP_443099.1| voltage gated channel like 1; four ... 174 2e-41
gi|29422146|gb|AAO84496.1| U-type voltage-gated cation channel a... 174 3e-41
gi|47205971|emb|CAF91180.1| unnamed protein product [Tetraodon n... 172 6e-41
gi|49078690|ref|XP_403073.1| hypothetical protein UM05458.1 [Ust... 170 3e-40
gi|50258561|gb|EAL21248.1| hypothetical protein CNBD3030 [Crypto... 170 4e-40
gi|31230342|ref|XP_318373.1| ENSANGP00000024607 [Anopheles gambi... 170 4e-40
gi|14329511|emb|CAC40696.1| bA430M15.1 (novel protein (ortholog ... 168 2e-39
gi|24025650|ref|NP_705894.1| voltage gated channel like 1 [Rattu... 167 4e-39
gi|50750509|ref|XP_422026.1| PREDICTED: similar to Sodium channe... 167 4e-39
gi|38077923|ref|XP_139476.2| similar to low voltage-activated T-... 166 6e-39
gi|27261714|gb|AAN86029.1| alpha-1 calcium channel subunit Cch1 ... 165 1e-38
gi|46439877|gb|EAK99189.1| hypothetical protein CaO19.3298 [Cand... 165 1e-38
gi|840654|gb|AAA67695.1| sodium channel 165 1e-38
gi|38505294|ref|NP_938407.1| voltage-dependent calcium channel a... 164 2e-38
gi|4959453|gb|AAD34352.1| T-type calcium channel alpha 1G [Homo ... 164 2e-38
gi|31230334|ref|XP_318372.1| ENSANGP00000015994 [Anopheles gambi... 164 2e-38
gi|50750507|ref|XP_422025.1| PREDICTED: similar to Sodium channe... 163 4e-38
gi|24641966|ref|NP_727772.1| CG1517-PB [Drosophila melanogaster]... 163 4e-38
gi|26245709|gb|AAN77520.1| alpha1U protein [Drosophila melanogas... 163 4e-38
gi|24641968|ref|NP_727773.1| CG1517-PC [Drosophila melanogaster]... 163 4e-38
gi|50732219|ref|XP_418534.1| PREDICTED: similar to Sodium channe... 163 5e-38
gi|50553136|ref|XP_503978.1| hypothetical protein [Yarrowia lipo... 162 9e-38
gi|14165228|gb|AAK55439.1| sodium channel 3 [Sternopygus macrurus] 161 1e-37
gi|8559|emb|CAA32571.1| sodium channel protein [Drosophila melan... 160 3e-37
gi|7243093|dbj|BAA92594.1| KIAA1356 protein [Homo sapiens] 160 4e-37
gi|50421135|ref|XP_459113.1| unnamed protein product [Debaryomyc... 158 1e-36
gi|825475|gb|AAA67107.1| sodium channel 3 157 3e-36
gi|14165232|gb|AAK55441.1| sodium channel 5 [Sternopygus macrurus] 157 3e-36
gi|47191841|emb|CAF93396.1| unnamed protein product [Tetraodon n... 155 1e-35
gi|47190277|emb|CAF94201.1| unnamed protein product [Tetraodon n... 154 3e-35
gi|346365|pir||S29184 sodium channel protein I - human (fragment... 153 4e-35
gi|26522477|dbj|BAC44831.1| skeletal muscle sodium channel [Gall... 153 5e-35
gi|41055985|ref|NP_956426.1| similar to sodium channel, voltage-... 151 2e-34
gi|2665782|gb|AAC29514.1| voltage-gated sodium channel, subtype ... 150 3e-34
gi|2665784|gb|AAC29515.1| voltage-gated sodium channel, subtype ... 149 8e-34
gi|47207766|emb|CAG05433.1| unnamed protein product [Tetraodon n... 146 6e-33
gi|14165230|gb|AAK55440.1| sodium channel 4 [Sternopygus macrurus] 145 1e-32
gi|848992|gb|AAA68000.1| sodium channel 145 1e-32
gi|32423047|ref|XP_331961.1| hypothetical protein [Neurospora cr... 144 2e-32
gi|14165234|gb|AAK55442.1| sodium channel 6 [Sternopygus macrurus] 144 2e-32
gi|15824797|gb|AAL09474.1| voltage-dependent calcium channel sub... 144 2e-32
gi|37785956|gb|AAO53229.1| voltage gated N-type calcium channel ... 144 3e-32
gi|2143634|pir||A46422 calcium channel alpha-1 subunit - rat (fr... 143 4e-32
gi|27819103|gb|AAO23570.1| sodium channel 7 [Sternopygus macrurus] 143 5e-32
>gi|21693922|gb|AAM75372.1| Egg laying defective protein 19, isoform b
[Caenorhabditis elegans]
Length = 1877
Score = 3332 bits (8640), Expect = 0.0
Identities = 1685/1877 (89%), Positives = 1685/1877 (89%)
Frame = +1
Query: 1 MSVLASMMSSGXXXXXXXXXXXXRTDLWXXXXXXXXXXXXXXXXTKKRPAQRKPLRQTNV 180
MSVLASMMSSG RTDLW TKKRPAQRKPLRQTNV
Sbjct: 1 MSVLASMMSSGEDEEQAAADEQERTDLWQQTLQAAVAASSSQDATKKRPAQRKPLRQTNV 60
Query: 181 VXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKN 360
V NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKN
Sbjct: 61 VERSERSLLCLSLNNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKN 120
Query: 361 TLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMS 540
TLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMS
Sbjct: 121 TLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMS 180
Query: 541 IQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGL 720
IQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGL
Sbjct: 181 IQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGL 240
Query: 721 ELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWP 900
ELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWP
Sbjct: 241 ELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWP 300
Query: 901 GPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVL 1080
GPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVL
Sbjct: 301 GPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVL 360
Query: 1081 NLVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQED 1260
NLVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQED
Sbjct: 361 NLVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQED 420
Query: 1261 EPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXX 1440
EPVAQT PSKWAARMKRLEKLN LVKSQTFYW
Sbjct: 421 EPVAQTVVGEEADEEGEERVEDVRPSKWAARMKRLEKLNRRCRRACRRLVKSQTFYWLVI 480
Query: 1441 XXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRF 1620
TSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRF
Sbjct: 481 LLVLLNTLVLTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRF 540
Query: 1621 DCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXX 1800
DCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWT
Sbjct: 541 DCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTSLRNLVSSLLNSLRSI 600
Query: 1801 XXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNT 1980
GMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNT
Sbjct: 601 ISLLLLLFLFIVIFALLGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNT 660
Query: 1981 VMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNAXXXXX 2160
VMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNA
Sbjct: 661 VMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNAEKEEE 720
Query: 2161 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSARPRRMSEVPAASTVKPIPKASSLFI 2340
MTSARPRRMSEVPAASTVKPIPKASSLFI
Sbjct: 721 QQEIEGEDEEFEEGEDEGEEHGMDEPEGDEEMTSARPRRMSEVPAASTVKPIPKASSLFI 780
Query: 2341 LSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMILNYFDYFFTS 2520
LSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMILNYFDYFFTS
Sbjct: 781 LSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMILNYFDYFFTS 840
Query: 2521 VFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXXXXXXXX 2700
VFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMS
Sbjct: 841 VFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSVVKILRVLRV 900
Query: 2701 XXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLS 2880
AINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLS
Sbjct: 901 LRPLRAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLS 960
Query: 2881 KMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLY 3060
KMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLY
Sbjct: 961 KMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLY 1020
Query: 3061 VAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIVTFQNEGEREYENCEL 3240
VAIDSNEEDKGPIHNSRQAVAL GFVIVTFQNEGEREYENCEL
Sbjct: 1021 VAIDSNEEDKGPIHNSRQAVALFFIAFIIVIAFFMMNIFVGFVIVTFQNEGEREYENCEL 1080
Query: 3241 DKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYP 3420
DKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYP
Sbjct: 1081 DKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYP 1140
Query: 3421 SSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGK 3600
SSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGK
Sbjct: 1141 SSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGK 1200
Query: 3601 LNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIY 3780
LNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIY
Sbjct: 1201 LNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIY 1260
Query: 3781 AVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCD 3960
AVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCD
Sbjct: 1261 AVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCD 1320
Query: 3961 PMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGP 4140
PMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGP
Sbjct: 1321 PMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGP 1380
Query: 4141 HHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLN 4320
HHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLN
Sbjct: 1381 HHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLN 1440
Query: 4321 SDGTVCFNATLFALVRTNLKIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKE 4500
SDGTVCFNATLFALVRTNLKIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKE
Sbjct: 1441 SDGTVCFNATLFALVRTNLKIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKE 1500
Query: 4501 DDVTVGKFYATFLIQDYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRA 4680
DDVTVGKFYATFLIQDYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRA
Sbjct: 1501 DDVTVGKFYATFLIQDYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRA 1560
Query: 4681 ISGNLETDFNFDEPEPQHRRPHSLFNNLVHRLSGAGSKSPTEHERIEKGSTLLPFQPRSF 4860
ISGNLETDFNFDEPEPQHRRPHSLFNNLVHRLSGAGSKSPTEHERIEKGSTLLPFQPRSF
Sbjct: 1561 ISGNLETDFNFDEPEPQHRRPHSLFNNLVHRLSGAGSKSPTEHERIEKGSTLLPFQPRSF 1620
Query: 4861 SPTHSLAGAEGSPVPSQMHRGAPINQSINLPPVNGSARRLPALPPYANHIHDETDDGPRY 5040
SPTHSLAGAEGSPVPSQMHRGAPINQSINLPPVNGSARRLPALPPYANHIHDETDDGPRY
Sbjct: 1621 SPTHSLAGAEGSPVPSQMHRGAPINQSINLPPVNGSARRLPALPPYANHIHDETDDGPRY 1680
Query: 5041 RDTGDRAGYDQSSRMVVANRNLPVDPDEEEQWMRSGGPSNRSDRRNPHLREPMLVXXXXX 5220
RDTGDRAGYDQSSRMVVANRNLPVDPDEEEQWMRSGGPSNRSDRRNPHLREPMLV
Sbjct: 1681 RDTGDRAGYDQSSRMVVANRNLPVDPDEEEQWMRSGGPSNRSDRRNPHLREPMLVARGAA 1740
Query: 5221 XXXXXMSSEAYEGTYRPVGEGKSVRLPFSSRPVLRPAEDSRPVDRLIGQSLGLGRYADAR 5400
MSSEAYEGTYRPVGEGKSVRLPFSSRPVLRPAEDSRPVDRLIGQSLGLGRYADAR
Sbjct: 1741 LALAGMSSEAYEGTYRPVGEGKSVRLPFSSRPVLRPAEDSRPVDRLIGQSLGLGRYADAR 1800
Query: 5401 IVGAARREIEEAYSLGEQEIDLAADSLAPLMQHVGMHDIRDINENSRSALLRPAENSSRQ 5580
IVGAARREIEEAYSLGEQEIDLAADSLAPLMQHVGMHDIRDINENSRSALLRPAENSSRQ
Sbjct: 1801 IVGAARREIEEAYSLGEQEIDLAADSLAPLMQHVGMHDIRDINENSRSALLRPAENSSRQ 1860
Query: 5581 HDSRGGSQEDLLLVTTL 5631
HDSRGGSQEDLLLVTTL
Sbjct: 1861 HDSRGGSQEDLLLVTTL 1877
>gi|25314568|pir||C88728 protein C48A7.1 [imported] - Caenorhabditis
elegans
Length = 1917
Score = 3295 bits (8543), Expect = 0.0
Identities = 1678/1917 (87%), Positives = 1679/1917 (87%), Gaps = 46/1917 (2%)
Frame = +1
Query: 19 MMSSGXXXXXXXXXXXXRTDLWXXXXXXXXXXXXXXXXTKKRPAQRKPLRQTNVVXXXXX 198
MMSSG RTDLW TKKRPAQRKPLRQTNVV
Sbjct: 1 MMSSGEDEEQAAADEQERTDLWQQTLQAAVAASSSQDATKKRPAQRKPLRQTNVVERSER 60
Query: 199 XXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLL--- 369
NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLL
Sbjct: 61 SLLCLSLNNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLVSH 120
Query: 370 --------------------------------ETIEYVFIVVFTIECVLKIVAMGFMFHP 453
ETIEYVFIVVFTIECVLKIVAMGFMFHP
Sbjct: 121 KIKKKHTKDESSNKTSLILFYGNNYKCYFKLQETIEYVFIVVFTIECVLKIVAMGFMFHP 180
Query: 454 SAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVL 633
SAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVL
Sbjct: 181 SAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVL 240
Query: 634 NAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDT 813
NAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDT
Sbjct: 241 NAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDT 300
Query: 814 EGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDV 993
EGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDV
Sbjct: 301 EGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDV 360
Query: 994 MYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQ 1173
MYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQ
Sbjct: 361 MYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQ 420
Query: 1174 QLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKWAAR 1353
QLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVAQT PSKWAAR
Sbjct: 421 QLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVAQTVVGEEADEEGEERVEDVRPSKWAAR 480
Query: 1354 MKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLF 1533
MKRLEKLN LVKSQTFYW TSEHYGQSEWLDHFQTMANLF
Sbjct: 481 MKRLEKLNRRCRRACRRLVKSQTFYWLVILLVLLNTLVLTSEHYGQSEWLDHFQTMANLF 540
Query: 1534 FVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSA 1713
FVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSA
Sbjct: 541 FVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSA 600
Query: 1714 RLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQ 1893
RLLRIFKVTKYWT GMQVFGGKFNFNPQ
Sbjct: 601 RLLRIFKVTKYWTSLRNLVSSLLNSLRSIISLLLLLFLFIVIFALLGMQVFGGKFNFNPQ 660
Query: 1894 QPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGN 2073
QPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGN
Sbjct: 661 QPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGN 720
Query: 2074 YILLNVFLAIAVDNLADADSLTNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 2253
YILLNVFLAIAVDNLADADSLTNA
Sbjct: 721 YILLNVFLAIAVDNLADADSLTNAEKEEEQQEIEGEDEEFEEGEDEGEEHGMDEPEGDEE 780
Query: 2254 MTSARPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVS 2433
MTSARPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVS
Sbjct: 781 MTSARPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVS 840
Query: 2434 SAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLD 2613
SAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLD
Sbjct: 841 SAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLD 900
Query: 2614 ILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIM 2793
ILVVAVSLTSFVLRTDAMS AINRAKGLKHVVQCVIVAVKTIGNIM
Sbjct: 901 ILVVAVSLTSFVLRTDAMSVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIM 960
Query: 2794 LVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSN 2973
LVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSN
Sbjct: 961 LVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSN 1020
Query: 2974 NDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXX 3153
NDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVAL
Sbjct: 1021 NDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALFFIAFIIVI 1080
Query: 3154 XXXXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVW 3333
GFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVW
Sbjct: 1081 AFFMMNIFVGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVW 1140
Query: 3334 WFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVAL 3513
WFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVAL
Sbjct: 1141 WFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVAL 1200
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG
Sbjct: 1201 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 1260
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAA 3873
IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAA
Sbjct: 1261 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAA 1320
Query: 3874 ILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFML 4053
ILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFML
Sbjct: 1321 ILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFML 1380
Query: 4054 CSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLR 4233
CSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLR
Sbjct: 1381 CSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLR 1440
Query: 4234 KISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNIDEAN 4413
KISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNIDEAN
Sbjct: 1441 KISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNIDEAN 1500
Query: 4414 EQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEMEAKG 4593
EQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEMEAKG
Sbjct: 1501 EQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEMEAKG 1560
Query: 4594 VLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDEPEPQHRRPHSLFNNLVHR 4773
VLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDEPEPQHRRPHSLFNNLVHR
Sbjct: 1561 VLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDEPEPQHRRPHSLFNNLVHR 1620
Query: 4774 LSGAGSKSPTEHERIEKGSTLLPF-----------QPRSFSPTHSLAGAEGSPVPSQMHR 4920
LSGAGSKSPTEHERIEKGSTLLPF +PRSFSPTHSLAGAEGSPVPSQMHR
Sbjct: 1621 LSGAGSKSPTEHERIEKGSTLLPFLTIRNSKKNKRKPRSFSPTHSLAGAEGSPVPSQMHR 1680
Query: 4921 GAPINQSINLPPVNGSARRLPALPPYANHIHDETDDGPRYRDTGDRAGYDQSSRMVVANR 5100
GAPINQSINLPPVNGSARRLPALPPYANHIHDETDDGPRYRDTGDRAGYDQSSRMVVANR
Sbjct: 1681 GAPINQSINLPPVNGSARRLPALPPYANHIHDETDDGPRYRDTGDRAGYDQSSRMVVANR 1740
Query: 5101 NLPVDPDEEEQWMRSGGPSNRSDRRNPHLREPMLVXXXXXXXXXXMSSEAYEGTYRPVGE 5280
NLPVDPDEEEQWMRSGGPSNRSDRRNPHLREPMLV MSSEAYEGTYRPVGE
Sbjct: 1741 NLPVDPDEEEQWMRSGGPSNRSDRRNPHLREPMLVARGAALALAGMSSEAYEGTYRPVGE 1800
Query: 5281 GKSVRLPFSSRPVLRPAEDSRPVDRLIGQSLGLGRYADARIVGAARREIEEAYSLGEQEI 5460
GKSVRLPFSSRPVLRPAEDSRPVDRLIGQSLGLGRYADARIVGAARREIEEAYSLGEQEI
Sbjct: 1801 GKSVRLPFSSRPVLRPAEDSRPVDRLIGQSLGLGRYADARIVGAARREIEEAYSLGEQEI 1860
Query: 5461 DLAADSLAPLMQHVGMHDIRDINENSRSALLRPAENSSRQHDSRGGSQEDLLLVTTL 5631
DLAADSLAPLMQHVGMHDIRDINENSRSALLRPAENSSRQHDSRGGSQEDLLLVTTL
Sbjct: 1861 DLAADSLAPLMQHVGMHDIRDINENSRSALLRPAENSSRQHDSRGGSQEDLLLVTTL 1917
>gi|25145845|ref|NP_741442.1| voltage-gated Calcium Channel Alpha
subunit, putative L-type calcium channel alpha 1 subunit,
EGg Laying defective EGL-19, EATing: abnormal pharyngeal
pumping EAT-12, Paralysed Arrest at Two-fold PAT-5 (202.6
kD) (egl-19) [Caenorhabditis elegans]
gi|7511600|pir||T37258 probable voltage-dependent calcium channel
complex alpha-1 chain, L-type - Caenorhabditis elegans
gi|2547169|gb|AAC47755.1| putative L-type calcium channel alpha 1
subunit [Caenorhabditis elegans]
gi|15145716|gb|AAB03158.4| Egg laying defective protein 19, isoform a
[Caenorhabditis elegans]
Length = 1783
Score = 3005 bits (7791), Expect = 0.0
Identities = 1518/1700 (89%), Positives = 1518/1700 (89%)
Frame = +1
Query: 1 MSVLASMMSSGXXXXXXXXXXXXRTDLWXXXXXXXXXXXXXXXXTKKRPAQRKPLRQTNV 180
MSVLASMMSSG RTDLW TKKRPAQRKPLRQTNV
Sbjct: 1 MSVLASMMSSGEDEEQAAADEQERTDLWQQTLQAAVAASSSQDATKKRPAQRKPLRQTNV 60
Query: 181 VXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKN 360
V NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKN
Sbjct: 61 VERSERSLLCLSLNNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKN 120
Query: 361 TLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMS 540
TLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMS
Sbjct: 121 TLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMS 180
Query: 541 IQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGL 720
IQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGL
Sbjct: 181 IQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGL 240
Query: 721 ELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWP 900
ELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWP
Sbjct: 241 ELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWP 300
Query: 901 GPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVL 1080
GPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVL
Sbjct: 301 GPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVL 360
Query: 1081 NLVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQED 1260
NLVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQED
Sbjct: 361 NLVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQED 420
Query: 1261 EPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXX 1440
EPVAQT PSKWAARMKRLEKLN LVKSQTFYW
Sbjct: 421 EPVAQTVVGEEADEEGEERVEDVRPSKWAARMKRLEKLNRRCRRACRRLVKSQTFYWLVI 480
Query: 1441 XXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRF 1620
TSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRF
Sbjct: 481 LLVLLNTLVLTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRF 540
Query: 1621 DCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXX 1800
DCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWT
Sbjct: 541 DCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTSLRNLVSSLLNSLRSI 600
Query: 1801 XXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNT 1980
GMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNT
Sbjct: 601 ISLLLLLFLFIVIFALLGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNT 660
Query: 1981 VMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNAXXXXX 2160
VMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNA
Sbjct: 661 VMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNAEKEEE 720
Query: 2161 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSARPRRMSEVPAASTVKPIPKASSLFI 2340
MTSARPRRMSEVPAASTVKPIPKASSLFI
Sbjct: 721 QQEIEGEDEEFEEGEDEGEEHGMDEPEGDEEMTSARPRRMSEVPAASTVKPIPKASSLFI 780
Query: 2341 LSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMILNYFDYFFTS 2520
LSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMILNYFDYFFTS
Sbjct: 781 LSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMILNYFDYFFTS 840
Query: 2521 VFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXXXXXXXX 2700
VFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMS
Sbjct: 841 VFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSVVKILRVLRV 900
Query: 2701 XXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLS 2880
AINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLS
Sbjct: 901 LRPLRAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLS 960
Query: 2881 KMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLY 3060
KMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLY
Sbjct: 961 KMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLY 1020
Query: 3061 VAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIVTFQNEGEREYENCEL 3240
VAIDSNEEDKGPIHNSRQAVAL GFVIVTFQNEGEREYENCEL
Sbjct: 1021 VAIDSNEEDKGPIHNSRQAVALFFIAFIIVIAFFMMNIFVGFVIVTFQNEGEREYENCEL 1080
Query: 3241 DKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYP 3420
DKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYP
Sbjct: 1081 DKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYP 1140
Query: 3421 SSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGK 3600
SSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGK
Sbjct: 1141 SSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGK 1200
Query: 3601 LNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIY 3780
LNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIY
Sbjct: 1201 LNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIY 1260
Query: 3781 AVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCD 3960
AVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCD
Sbjct: 1261 AVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCD 1320
Query: 3961 PMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGP 4140
PMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGP
Sbjct: 1321 PMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGP 1380
Query: 4141 HHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLN 4320
HHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLN
Sbjct: 1381 HHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLN 1440
Query: 4321 SDGTVCFNATLFALVRTNLKIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKE 4500
SDGTVCFNATLFALVRTNLKIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKE
Sbjct: 1441 SDGTVCFNATLFALVRTNLKIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKE 1500
Query: 4501 DDVTVGKFYATFLIQDYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRA 4680
DDVTVGKFYATFLIQDYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRA
Sbjct: 1501 DDVTVGKFYATFLIQDYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRA 1560
Query: 4681 ISGNLETDFNFDEPEPQHRRPHSLFNNLVHRLSGAGSKSPTEHERIEKGSTLLPFQPRSF 4860
ISGNLETDFNFDEPEPQHRRPHSLFNNLVHRLSGAGSKSPTEHERIEKGSTLLPFQPRSF
Sbjct: 1561 ISGNLETDFNFDEPEPQHRRPHSLFNNLVHRLSGAGSKSPTEHERIEKGSTLLPFQPRSF 1620
Query: 4861 SPTHSLAGAEGSPVPSQMHRGAPINQSINLPPVNGSARRLPALPPYANHIHDETDDGPRY 5040
SPTHSLAGAEGSPVPSQMHRGAPINQSINLPPVNGSARRLPALPPYANHIHDETDDGPRY
Sbjct: 1621 SPTHSLAGAEGSPVPSQMHRGAPINQSINLPPVNGSARRLPALPPYANHIHDETDDGPRY 1680
Query: 5041 RDTGDRAGYDQSSRMVVANR 5100
RDTGDRAGYDQSSRMVVANR
Sbjct: 1681 RDTGDRAGYDQSSRMVVANR 1700
Score = 162 bits (409), Expect = 1e-37
Identities = 86/106 (81%), Positives = 89/106 (83%)
Frame = +1
Query: 5314 PVLRPAEDSRPVDRLIGQSLGLGRYADARIVGAARREIEEAYSLGEQEIDLAADSLAPLM 5493
P R D D+ + +YADARIVGAARREIEEAYSLGEQEIDLAADSLAPLM
Sbjct: 1678 PRYRDTGDRAGYDQSSRMVVANRKYADARIVGAARREIEEAYSLGEQEIDLAADSLAPLM 1737
Query: 5494 QHVGMHDIRDINENSRSALLRPAENSSRQHDSRGGSQEDLLLVTTL 5631
QHVGMHDIRDINENSRSALLRPAENSSRQHDSRGGSQEDLLLVTTL
Sbjct: 1738 QHVGMHDIRDINENSRSALLRPAENSSRQHDSRGGSQEDLLLVTTL 1783
>gi|39593582|emb|CAE61874.1| Hypothetical protein CBG05858
[Caenorhabditis briggsae]
Length = 1780
Score = 2952 bits (7652), Expect = 0.0
Identities = 1489/1698 (87%), Positives = 1504/1698 (87%), Gaps = 1/1698 (0%)
Frame = +1
Query: 10 LASMMSSGXXXXXXXXXXXXRTDLWXXXXXXXXXXXXXXXXTKKRPAQRKPLRQTNVVXX 189
LASMMSSG R+DLW TKKRPAQRKPLRQTNVV
Sbjct: 1 LASMMSSGEDEEQAAADEQERSDLWQQTLQAAVAASSSQDATKKRPAQRKPLRQTNVVER 60
Query: 190 XXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLL 369
NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLL
Sbjct: 61 SERSLLCLSLNNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLL 120
Query: 370 ETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG 549
ETIEYVFIVVFTIECVLKIVAMGF+FHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG
Sbjct: 121 ETIEYVFIVVFTIECVLKIVAMGFLFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG 180
Query: 550 FDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELF 729
FDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELF
Sbjct: 181 FDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELF 240
Query: 730 CGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPN 909
CGKLHSTCIDPATGQLAQKDPTPCG D GSAFKC+PSDSLTNMGVRWECSSNTTWPGPN
Sbjct: 241 CGKLHSTCIDPATGQLAQKDPTPCGND--GSAFKCRPSDSLTNMGVRWECSSNTTWPGPN 298
Query: 910 NGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLV 1089
NGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLV
Sbjct: 299 NGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLV 358
Query: 1090 LGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPV 1269
LGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEP
Sbjct: 359 LGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPA 418
Query: 1270 AQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXX 1449
A PSKW+AR+KRLEK N LVKSQTFYW
Sbjct: 419 AAAVTGEEVDEEGEERVEDVRPSKWSARVKRLEKFNRRCRRACRRLVKSQTFYWLVILLV 478
Query: 1450 XXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCF 1629
TSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCF
Sbjct: 479 LLNTLVLTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCF 538
Query: 1630 VVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXX 1809
VVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWT
Sbjct: 539 VVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTSLRNLVSSLLNSLRSIISL 598
Query: 1810 XXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMY 1989
GMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMY
Sbjct: 599 LLLLFLFIVIFALLGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMY 658
Query: 1990 HGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNAXXXXXXXX 2169
HGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNA
Sbjct: 659 HGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNAEKEEEQQE 718
Query: 2170 XXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSARPRRMSEVPAASTVKPIPKASSLFILSH 2349
MTSARPRRMSEVPAASTVKPIPKASSLFILSH
Sbjct: 719 IEGEDEEFDEGEEEGDEHGAEEPEGEEDMTSARPRRMSEVPAASTVKPIPKASSLFILSH 778
Query: 2350 TNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMILNYFDYFFTSVFT 2529
TNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNM+LNYFDYFFTSVFT
Sbjct: 779 TNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMVLNYFDYFFTSVFT 838
Query: 2530 VEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXX 2709
VEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMS
Sbjct: 839 VEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSVVKILRVLRVLRP 898
Query: 2710 XXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMT 2889
AINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMT
Sbjct: 899 LRAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMT 958
Query: 2890 EAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAI 3069
EAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAM+SLFVVSTFEGWPQLLYVAI
Sbjct: 959 EAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMVSLFVVSTFEGWPQLLYVAI 1018
Query: 3070 DSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIVTFQNEGEREYENCELDKN 3249
DSNEEDKGP+HNSRQAVAL GFVIVTFQNEGEREYENCELDKN
Sbjct: 1019 DSNEEDKGPVHNSRQAVALFFIAFIIVIAFFMMNIFVGFVIVTFQNEGEREYENCELDKN 1078
Query: 3250 QRKCIEFALKAKPHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSR 3429
QRKCIEFALKAKPHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSR
Sbjct: 1079 QRKCIEFALKAKPHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSR 1138
Query: 3430 GFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNP 3609
GFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNP
Sbjct: 1139 GFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNP 1198
Query: 3610 GGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVI 3789
GGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVI
Sbjct: 1199 GGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVI 1258
Query: 3790 GMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMS 3969
GMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMS
Sbjct: 1259 GMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMS 1318
Query: 3970 DDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHL 4149
DDY KGG NESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHL
Sbjct: 1319 DDYSKGGFNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHL 1378
Query: 4150 EEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDG 4329
EEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDG
Sbjct: 1379 EEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDG 1438
Query: 4330 TVCFNATLFALVRTNLKIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDV 4509
TVCFNATLFALVRTNLKIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDV
Sbjct: 1439 TVCFNATLFALVRTNLKIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDV 1498
Query: 4510 TVGKFYATFLIQDYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISG 4689
TVGKFYATFLIQDYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISG
Sbjct: 1499 TVGKFYATFLIQDYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISG 1558
Query: 4690 NLETDFNFDEPEPQHRRPHSLFNNLVHRLSGAGSKSPTEHERIEKGSTLLPFQPRSFSPT 4869
NLETDFNFDEPEPQHRRPHSLFNNLVHRLSGAG+KSPTEHER+E+G+TLLP++ RSFSPT
Sbjct: 1559 NLETDFNFDEPEPQHRRPHSLFNNLVHRLSGAGAKSPTEHERLERGATLLPYEARSFSPT 1618
Query: 4870 HSLAGAEGSPVPSQMHRGAPINQSINLPPVNGSARRLPALPPYANHIHDETDDGPRYRDT 5049
HSLAGAEGSPVPSQMHRGAPINQSINLPPVNGSARRLPALPPYANHIHDETDDGPRYRDT
Sbjct: 1619 HSLAGAEGSPVPSQMHRGAPINQSINLPPVNGSARRLPALPPYANHIHDETDDGPRYRDT 1678
Query: 5050 GDRAGYDQS-SRMVVANR 5100
GDRAGYD S +RMVVANR
Sbjct: 1679 GDRAGYDPSQNRMVVANR 1696
Score = 148 bits (374), Expect = 1e-33
Identities = 76/84 (90%), Positives = 80/84 (94%), Gaps = 1/84 (1%)
Frame = +1
Query: 5383 RYADARIVGAARREIEEAYSLGEQEIDLAADSLAPLMQHVGMHDIRDINENSRSALLRPA 5562
+YADAR+VGAARREIEEAY LGEQEID+AADSLAPLMQHVGMHDIRDINENSRSALLRPA
Sbjct: 1697 KYADARVVGAARREIEEAYQLGEQEIDMAADSLAPLMQHVGMHDIRDINENSRSALLRPA 1756
Query: 5563 -ENSSRQHDSRGGSQEDLLLVTTL 5631
E+S RQHDS GGSQEDLLLVTTL
Sbjct: 1757 GESSRRQHDSHGGSQEDLLLVTTL 1780
>gi|45120100|ref|NP_982351.1| L-type calcium channel pore subunit
isoform 1.3a; si:dz136d19.3; si:dz223c6.1 [Danio rerio]
gi|42564144|gb|AAS20586.1| L-type calcium channel pore subunit
isoform 1.3a [Danio rerio]
Length = 2082
Score = 1713 bits (4437), Expect = 0.0
Identities = 893/1591 (56%), Positives = 1094/1591 (68%), Gaps = 65/1591 (4%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
NNPIR+ CIS+VEWKPF+ IL I ANC+ALA+Y P+P DS+ N LET+EY F+++
Sbjct: 64 NNPIRRACISLVEWKPFDIFILIAIFANCMALAVYVPFPEDDSNSTNHDLETVEYAFLII 123
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG---------- 549
FTIE LKI+A G + H +AY+RN WN+LDF+IVVIGL S +L ++ +G
Sbjct: 124 FTIETFLKIIAYGLVMHQNAYVRNGWNMLDFVIVVIGLFSVVLEVLTKEGGEKEEVGENL 183
Query: 550 -----------FDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVI 696
FDVKALRAFRVLRPLRLVSGVPSLQVVLN+I++AM+PLLHIALLVLFVI
Sbjct: 184 SAHGHGGKPGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVI 243
Query: 697 LIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWE 876
+IYAIIGLELF GK+H++C T + + +P PC + G C + +L G
Sbjct: 244 IIYAIIGLELFIGKMHASCYFQGT-DILEDEPAPCAVNGHGRT--CPINGTLCKEG---- 296
Query: 877 CSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLV 1056
W GPN GITNFDNF AMLTVFQC+++EGWTDV+YW+NDA+G E PW+YFV+LV
Sbjct: 297 ------WQGPNGGITNFDNFMFAMLTVFQCITMEGWTDVLYWMNDAMGLELPWVYFVSLV 350
Query: 1057 ILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEP 1236
I GSFFVLNLVLGVLSGEFSKEREKA+ARG FQK REKQQLEEDLKGYLDWITQAEDI+P
Sbjct: 351 IFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDP 410
Query: 1237 VNEDEQEDE-------------------------------PVAQTXXXXXXXXXXXXXXX 1323
NE+E+E+ P ++T
Sbjct: 411 ENEEEEEESKRNRVTLASLMEKKKKGFGWFSQSSDTHASMPASETESMNTENEKGEDEKA 470
Query: 1324 X--------XXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSE 1479
SK++ R +R +L VKS FYW +SE
Sbjct: 471 TCCGPTCQKISKSKFSRRWRRWNRLCRRNCRLA---VKSVPFYWLVIILVFLNTLTISSE 527
Query: 1480 HYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFV 1659
HY Q WL Q +AN + +F+ EML+KMYSLG Y S FNRFDCFVV I E +
Sbjct: 528 HYNQPMWLTQVQDVANKVLLAMFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETI 587
Query: 1660 LVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1839
LV F++M PLG+SV R RLLRIFKVT++W
Sbjct: 588 LVEFEIMSPLGISVFRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIII 647
Query: 1840 XXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVG 2019
GMQVFGGKFNF+ Q K R+ FD F QALLTVFQILTGEDWN VMY GI ++GG
Sbjct: 648 FSLLGMQVFGGKFNFDETQTK-RSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPS 706
Query: 2020 TLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNAXXXXXXXXXXXXXXXXXX 2199
+ G+IVCIY+I+LFICGNYILLNVFLAIAVDNLADA+SL N
Sbjct: 707 SSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESL-NTDDTKKPDEIDEIEDEAKA 765
Query: 2200 XXXXXXXXXXXXXXXXXXMTSARPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNM 2379
RP+ +SE+ + PIP+ S+ FI S+TN RV C+
Sbjct: 766 GEEDEKDNAEEDEEEPDVPAGPRPK-ISELVKKEKITPIPEGSAFFIFSNTNPVRVACHK 824
Query: 2380 VVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVF 2559
++NH FTN +L I++SSA LAAEDP++ S RN+IL YFDY FT++FTVEI LK+ +
Sbjct: 825 LINHHIFTNLILVFIMLSSASLAAEDPIRNFSARNIILGYFDYAFTAIFTVEIVLKMTTY 884
Query: 2560 GLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGL 2739
G HKG+FCRN FNLLD+LVV VSL SF +++ A+S AINRAKGL
Sbjct: 885 GAFLHKGAFCRNYFNLLDLLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGL 944
Query: 2740 KHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIH 2919
KHVVQCV VA++TIGNIM+VT +LQFMFA IGVQLFKG F+ CND +K + EC+G YI
Sbjct: 945 KHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCNDEAKSSPEECKGTYIL 1004
Query: 2920 YEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPI 3099
Y++GD +P+ +KR W N+DFNFDNV AM++LF VSTFEGWP LLY AIDSN E+ GPI
Sbjct: 1005 YKEGDVNQPIIQKRHWHNSDFNFDNVLMAMMALFTVSTFEGWPALLYKAIDSNRENMGPI 1064
Query: 3100 HNSRQAVALXXXXXXXXXXXXXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALK 3279
+N R +++ GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALK
Sbjct: 1065 YNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALK 1124
Query: 3280 AKPHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFN 3459
A+P RRYIP+N QY+ W+ V S FEY++F++I++NT+ LA +HY S F +D+ N
Sbjct: 1125 ARPLRRYIPKNPYQYKFWYVVNSTGFEYIMFVLILLNTICLAVQHYGQSELFNYVMDILN 1184
Query: 3460 LIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNL-ISIN 3636
++FT VF E VLK++A P++Y +D WN FD L+VVGS +DI ++N + ISI
Sbjct: 1185 MVFTAVFTVEMVLKLIAFKPRHYFTDAWNTFDALIVVGSVVDIAITEVNNTEDSARISIT 1244
Query: 3637 FFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVA 3816
FFRLFRVMRLVKLLSRGEGIRTLLWTF+KSFQALPYVALLI +LFFIYAVIGMQ FGK+A
Sbjct: 1245 FFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQVFGKIA 1304
Query: 3817 LDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLN 3996
+ D T I+RNNNF +FP A+L+LFR ATGEAWQ+IML+C + CDP SD Y+ G
Sbjct: 1305 MVDHTQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACMPGK--LCDPESD-YNPG--E 1359
Query: 3997 ESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSE 4176
E CG++FA YFI+F+MLC+FL+INLFVAVIMDNFDYLTRDWS LGPHHL+EF R+WSE
Sbjct: 1360 EMTCGSSFAIIYFITFYMLCAFLIINLFVAVIMDNFDYLTRDWSXLGPHHLDEFKRIWSE 1419
Query: 4177 YDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLF 4356
YDP+AKGRIKHLDVVTLLR+I PPLGFGKLCPHR+ACKRLV+MNMPLNSDGTV FNATLF
Sbjct: 1420 YDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLF 1479
Query: 4357 ALVRTNLKIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATF 4536
ALVRT KI TEGN+++ANE+LR+ IK+IWKRT LLD+VVPPAG +D+VTVGKFYATF
Sbjct: 1480 ALVRTAXKIKTEGNLEQANEELRAVIKKIWKRTSMKLLDQVVPPAG-DDEVTVGKFYATF 1538
Query: 4537 LIQDYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLE----TD 4704
LIQDYFR+FKKRKE GV PAQ A+ALQAGLRTLH+IGPE++RAIS +L+ D
Sbjct: 1539 LIQDYFRKFKKRKEEGLVGVHPAQNNTAIALQAGLRTLHDIGPEIRRAISCDLQDDELVD 1598
Query: 4705 FNFDEPEPQHRRPHSLFNNLVHRLSGAGSKS 4797
F +E E +RR LF N ++ ++G +S
Sbjct: 1599 FIPEEDEEIYRRNGGLFGNHINHINGDPRRS 1629
Score = 83.2 bits (204), Expect = 7e-14
Identities = 74/278 (26%), Positives = 118/278 (41%), Gaps = 34/278 (12%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPL---QANSTRNMILNY 2499
+LF L+ N R C +V F +L I + LA P +NST N L
Sbjct: 57 ALFCLNLNNPIRRACISLVEWKPFDIFILIAIFANCMALAVYVPFPEDDSNST-NHDLET 115
Query: 2500 FDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRT------- 2658
+Y F +FT+E LK+I +GLV H+ ++ RN +N+LD ++V + L S VL
Sbjct: 116 VEYAFLIIFTIETFLKIIAYGLVMHQNAYVRNGWNMLDFVIVVIGLFSVVLEVLTKEGGE 175
Query: 2659 -----DAMSX-----------XXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNI 2790
+ +S ++ L+ V+ +I A+ + +I
Sbjct: 176 KEEVGENLSAHGHGGKPGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHI 235
Query: 2791 MLVTFMLQFMFAIIGVQLFKG-----TFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSK 2955
L+ + ++AIIG++LF G +F D+ + A C + P
Sbjct: 236 ALLVLFVIIIYAIIGLELFIGKMHASCYFQGTDILEDEPAPCAVN--GHGRTCPINGTLC 293
Query: 2956 KRVWSNND---FNFDNVGDAMISLFVVSTFEGWPQLLY 3060
K W + NFDN AM+++F T EGW +LY
Sbjct: 294 KEGWQGPNGGITNFDNFMFAMLTVFQCITMEGWTDVLY 331
>gi|32478669|gb|AAP83587.1| neuroendocrine-type voltage-gated calcium
channel subunit Cav1.3 [Oncorhynchus mykiss]
Length = 2150
Score = 1681 bits (4352), Expect = 0.0
Identities = 914/1722 (53%), Positives = 1125/1722 (65%), Gaps = 89/1722 (5%)
Frame = +1
Query: 136 KKRPAQRKPLRQ-TNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIA 312
KKR K +Q +N NNPIR+ CIS+VEWKPF+ IL I ANC+A
Sbjct: 47 KKRAQYAKSKKQGSNANTRPARALFCLKLNNPIRRACISLVEWKPFDIFILIAIFANCMA 106
Query: 313 LAIYQPYPAQDSDYKN------------------TLLETIEYVFIVVFTIECVLKIVAMG 438
LA+Y P+P DS+ N LET+E+VF+V+FTIE LKI+A G
Sbjct: 107 LAVYIPFPQDDSNSTNHDLETVEHVFYFETPTPQPDLETVEHVFLVIFTIETFLKIIAYG 166
Query: 439 FMFHPSAYLRNAWNILDFIIVVIGLVSTIL---SKMSIQ--------------------- 546
+ H +AY+RN WN+LDF+IVV+GL S +L +K S++
Sbjct: 167 LVAHQNAYVRNGWNMLDFVIVVVGLFSVVLELLTKDSVETKEEAEAGAAAAAAAAALHPS 226
Query: 547 ---------GFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVIL 699
GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+I++AM+PLLHIALLVLFVI+
Sbjct: 227 AQGHGGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVII 286
Query: 700 IYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWEC 879
IYAIIGLELF GK+H+TC P+TG +A+ +P PC G +C + + EC
Sbjct: 287 IYAIIGLELFIGKMHATCFFPSTGMIAEDEPAPCAISGHGR--QCPINGT--------EC 336
Query: 880 SSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVI 1059
W GPN+GITNFDNF AMLTVFQC+++EGWTDV+YW+NDA+G E PW+YFV+LVI
Sbjct: 337 REG--WHGPNDGITNFDNFLFAMLTVFQCITMEGWTDVLYWMNDAMGLELPWVYFVSLVI 394
Query: 1060 LGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPV 1239
GSFFVLNLVLGVLSGEFSKEREKA+ARG FQK REKQQL+EDLKGYLDWITQAEDI+P
Sbjct: 395 FGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLDEDLKGYLDWITQAEDIDPD 454
Query: 1240 NEDEQEDE--------PVAQTXXXXXXXXXXXXXXX--------XXXPSKWAARMKRLEK 1371
NEDE+ E P ++T SK++ R +R
Sbjct: 455 NEDEEGYEEGKRNLSMPASETESVNTENVAEDEVKTPCCGPFCQKISKSKFSRRWRRW-- 512
Query: 1372 LNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFS 1551
N VKS FYW SEHY Q +WL Q +AN + LF+
Sbjct: 513 -NRFCRRKCRVAVKSVPFYWLVIILVFLNTLTI-SEHYXQPDWLTQVQDVANKVLLGLFT 570
Query: 1552 MEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIF 1731
EM+ KMYSLG Y S FNRFDCFVV I E +LV +M PLG+SV R RLLRIF
Sbjct: 571 CEMMTKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELAIMSPLGISVFRCVRLLRIF 630
Query: 1732 KVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRA 1911
KVT++W GMQVFGGKFNF+ Q K R+
Sbjct: 631 KVTRHWQSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQVFGGKFNFDETQTK-RS 689
Query: 1912 NFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNV 2091
FD F QALLTVFQI+TGEDWN VMY GI ++GG + G+IV Y+I+LFICGNYILLNV
Sbjct: 690 TFDNFPQALLTVFQIMTGEDWNAVMYDGIMAYGGPSSSGMIVSFYFIILFICGNYILLNV 749
Query: 2092 FLAIAVDNLADADSLTNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSARP 2271
FLAIAVDNL DA+SL A P
Sbjct: 750 FLAIAVDNLGDAESLNAPRDKKEEKKEDLVPVEEEEDNAAAEEEEEPE-------VPAGP 802
Query: 2272 RR-MSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLA 2448
R +SE+ + PIP S+ FI S TN RV C+ ++NH FT +L I++SS LA
Sbjct: 803 RPPISELVKKEKITPIPDGSAFFIFSKTNPIRVGCHKLINHHIFTTLILVFIMLSSVSLA 862
Query: 2449 AEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVA 2628
AEDP++ S RN++L Y DY FTS+FT EI LK+ +G HKG+FCRN FNLLD+LVV
Sbjct: 863 AEDPIRNFSARNIVLGYADYVFTSMFTFEIMLKMTTYGAFLHKGAFCRNTFNLLDLLVVG 922
Query: 2629 VSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFM 2808
VSL SF +++ A+S AINRAKGLKHV+QCV+ A++TIGNIM+VT +
Sbjct: 923 VSLVSFCIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVIQCVVGAIRTIGNIMIVTTL 982
Query: 2809 LQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNF 2988
LQFMFA IGVQLFKG F+ C D +K + EC+G YIH++DGD +P +KR ++FNF
Sbjct: 983 LQFMFACIGVQLFKGKFYRCTDEAKSSPDECKGTYIHFKDGDVNQPAIQKRERQKSEFNF 1042
Query: 2989 DNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXX 3168
DNV AM++LF VSTFEGWP LLY AIDSN E+ GPI+N R +++
Sbjct: 1043 DNVLMAMMALFTVSTFEGWPSLLYKAIDSNRENLGPIYNYRIEISIFFIIYIIIIAFFMM 1102
Query: 3169 XXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVTS 3348
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N QY+ W+ V S
Sbjct: 1103 NIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNS 1162
Query: 3349 RAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNY 3528
FEY++F++I++NT+ LA +HY S F +D+ N++FT VF E VLK++A P++Y
Sbjct: 1163 TGFEYIMFVLIMLNTLCLAVQHYGQSETFNYVMDILNMVFTAVFTAEMVLKLIAFKPRHY 1222
Query: 3529 ISDRWNVFDLLVVVGSFIDITYGKLNPGGTNL-ISINFFRLFRVMRLVKLLSRGEGIRTL 3705
++D WN FD L+VVGS +DI ++N + ISI FFRLFRVMRLVKLLSRGEGIRTL
Sbjct: 1223 LTDAWNTFDALIVVGSVVDIAITEVNNTEDSARISITFFRLFRVMRLVKLLSRGEGIRTL 1282
Query: 3706 LWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVL 3885
LWTF+KSFQALPYVALLI +LFFIYAVIGMQ FGKVA+ D T I+RNNNF +FP A+L+L
Sbjct: 1283 LWTFIKSFQALPYVALLIAMLFFIYAVIGMQVFGKVAMVDGTHINRNNNFQTFPQAVLLL 1342
Query: 3886 FRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFL 4065
FR ATGEAWQ+IML+C + CDP SD Y+ G E CG +FAY YFISF+MLC+FL
Sbjct: 1343 FRCATGEAWQEIMLACVSGK--LCDPESD-YNPG--EEMTCGASFAYIYFISFYMLCAFL 1397
Query: 4066 VINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+WSEYDP+AKGRIKHLDVVTLLR+I P
Sbjct: 1398 IINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQP 1457
Query: 4246 PLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNIDEANEQLR 4425
PLGFGKLCPHR+ACKRLV+MNMPLNSDGTV FNATLFALVRT LKI T+GN+++ANE+LR
Sbjct: 1458 PLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTDGNLEQANEELR 1517
Query: 4426 SAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEMEAKGVLPA 4605
+ IK+IWKRT LLD+VVPPAG +D+VTVGKFYATFL+QDYFR+FKKRKE GV +
Sbjct: 1518 AVIKKIWKRTSMKLLDQVVPPAG-DDEVTVGKFYATFLMQDYFRKFKKRKEEGLVGVHAS 1576
Query: 4606 QTPQAMALQAGLRTLHEIGPELKRAISGNLE----TDFNFDEPEPQHRRPHSLFNNLVHR 4773
Q+ A+ALQAGLRTLH+IGPE++RAIS +L+ DF +E E +RR LF N V+
Sbjct: 1577 QSNTAIALQAGLRTLHDIGPEIRRAISCDLQDEELVDFIPEEDEEIYRRNGGLFGNHVNH 1636
Query: 4774 LSGAGSKSPTEHERIEKG----STLLPFQ---PRSFS----PTHSLAGAEGSPVPSQMHR 4920
++G +H R G +T P Q P ++ P L A P+ HR
Sbjct: 1637 VNG-------DHHRRSSGQQTNTTQRPLQVQPPPHYAHMEQPVGRLCRANAMSHPNHHHR 1689
Query: 4921 GAPINQSINLPP----VNGSARRLPALPPYANHIHDETDDGP 5034
N S P +N + + +LP H H + P
Sbjct: 1690 HHHHNSSYGKSPKSTNINLNNANVSSLPNGGGHHHRYYEHAP 1731
>gi|21069133|gb|AAM33831.1| voltage-gated calcium channel subunit
Cav1.3 [Oncorhynchus mykiss]
Length = 2155
Score = 1660 bits (4298), Expect = 0.0
Identities = 931/1852 (50%), Positives = 1143/1852 (61%), Gaps = 132/1852 (7%)
Frame = +1
Query: 136 KKRPAQRKPLRQ-TNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIA 312
KKR K +Q +N NNPIR+ CIS+VEWKPF+ IL I ANC+A
Sbjct: 47 KKRAQYAKSKKQGSNANTRPARALFCLKLNNPIRRACISLVEWKPFDIFILIAIFANCMA 106
Query: 313 LAIYQPYPAQDSDYKN------------------TLLETIEYVFIVVFTIECVLKIVAMG 438
LA+Y P+P DS+ N LET+E+VF+V+FTIE LKI+A G
Sbjct: 107 LAVYIPFPQDDSNSTNHDLETVEHVFYFETPTPQPDLETVEHVFLVIFTIETFLKIIAYG 166
Query: 439 FMFHPSAYLRNAWNILDFIIVVIGLVSTIL---SKMSIQ--------------------- 546
+ H +AY+RN WN+LDF+IVV+GL S +L +K S++
Sbjct: 167 LVAHQNAYVRNGWNMLDFVIVVVGLFSVVLELLTKDSVETKEEAEAGAAAAAAAAALHPS 226
Query: 547 ---------GFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVIL 699
GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+I++AM+PLLHIALLVLFVI+
Sbjct: 227 AQGHGGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVII 286
Query: 700 IYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWEC 879
IYAIIGLELF GK+H+TC P+TG +A+ DP PC G +C + + EC
Sbjct: 287 IYAIIGLELFIGKMHATCFFPSTGMIAEDDPAPCAISGHGR--QCPINGT--------EC 336
Query: 880 SSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVI 1059
W GPNNGITNFDNF AMLTVFQC+++EGWTDV+YWVNDA+G P IYFV+L+I
Sbjct: 337 REG--WHGPNNGITNFDNFLFAMLTVFQCITMEGWTDVLYWVNDAIGFGTPAIYFVSLII 394
Query: 1060 LGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPV 1239
LGSFFVLNLVLGVLSGEFSKEREKA+ARG FQK REKQQLEEDLKGYLDWITQAEDI+P
Sbjct: 395 LGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPD 454
Query: 1240 NEDEQEDEPVAQ---TXXXXXXXXXXXXXXXXXXPSKWAARM------------------ 1356
NEDE+ +E + T S A M
Sbjct: 455 NEDEEGNEEGKRNRVTLADLTEKKKGSRFGWFSQSSDTHASMPASETESVNTENVAEDEV 514
Query: 1357 ---------KRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDH 1509
+R + N VKS FYW +SEHY Q +WL
Sbjct: 515 KTPCCGPFCRRWRRWNRFCRRKCRLAVKSVPFYWLVIILVFLNTLTISSEHYMQPDWLTQ 574
Query: 1510 FQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPL 1689
Q +AN + F+ EM+ KMYSLG Y S FNRFDCFVV I E +LV +M PL
Sbjct: 575 VQDVANKVLLGCFTCEMMTKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELAIMSPL 634
Query: 1690 GVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFG 1869
G+SV R RLLRIFKVT++W GMQVFG
Sbjct: 635 GISVFRCVRLLRIFKVTRHWQSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQVFG 694
Query: 1870 GKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYY 2049
GKFNF+ Q K R+ FD F QALLTVFQILTGEDWN VMY GI ++GG + G+IV Y+
Sbjct: 695 GKFNFDETQTK-RSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVSFYF 753
Query: 2050 IVLFICGNYILLNVF-LAIAVDNLADADSLTNAXXXXXXXXXXXXXXXXXXXXXXXXXXX 2226
I+LFICGNYILLNVF LAIAVDNL DA+SL
Sbjct: 754 IILFICGNYILLNVFFLAIAVDNLGDAESLNAPRDKKEEKKEDLVPVEEEEDNAAAEEEE 813
Query: 2227 XXXXXXXXXMTSARPRR-MSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFT 2403
A PR +SE+ + PIP S+ FI S TN RV C+ ++NH FT
Sbjct: 814 EPE-------VPAGPRPPISELVKKEKITPIPDGSAFFIFSKTNPIRVGCHKLINHHIFT 866
Query: 2404 NAVLFCILVSSAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGS 2583
N +L I++SS LAAEDP++ S RN++L Y DY FTS+FT EI LK+ +G HKG+
Sbjct: 867 NLILVFIMLSSVSLAAEDPIRNFSARNIVLGYADYVFTSMFTFEIMLKMTTYGAFLHKGA 926
Query: 2584 FCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVI 2763
FCRN FNLLD+LVV VSL SF +++ A+S AINRAKGLKHV+QCV+
Sbjct: 927 FCRNTFNLLDLLVVGVSLVSFCIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVIQCVV 986
Query: 2764 VAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTK 2943
A++TIGNIM+VT +LQFMFA IGVQLFKG F+ C D +K + EC+G YIH++DGD +
Sbjct: 987 GAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSSPDECKGTYIHFKDGDVNQ 1046
Query: 2944 PVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVA 3123
P +KR ++FNFDNV AM++LF VSTFEGWP LLY AIDSN E+ GPI+N R ++
Sbjct: 1047 PAIQKRERQKSEFNFDNVLMAMMALFTVSTFEGWPSLLYKAIDSNRENLGPIYNYRIEIS 1106
Query: 3124 LXXXXXXXXXXXXXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYI 3303
+ GFVIV FQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYI
Sbjct: 1107 IFFIIYIIIIAFFMMNIFVGFVIVNFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYI 1166
Query: 3304 PRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFA 3483
P+N QY+ W+ V S FEY++F++I++NT+ LA +HY S F +D+ N++FT VF
Sbjct: 1167 PKNPYQYKFWYVVNSTGFEYIMFVLIMLNTLCLAVQHYGQSETFNYVMDILNMVFTAVFT 1226
Query: 3484 FEAVLKIVALNPK----------NYISDRWNVFDLLVVVGSFIDITYGKL---------- 3603
E VLK++A P+ Y D WNVFD LVV+GS +DI ++
Sbjct: 1227 AEMVLKLIAFKPRLCVEKKDRDPGYFGDAWNVFDALVVMGSIVDIVLSEIDKLVEMARGP 1286
Query: 3604 -------------NPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPY 3744
N + ISI FFRLFRVMRLVKLLSRGEGIRTLLWTF+KSFQALPY
Sbjct: 1287 APPTEAPQLDESGNTEDSARISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPY 1346
Query: 3745 VALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIM 3924
VALLI +LFFIYAVIGMQ FGKVA+ D T I+RNNNF +FP A+L+LFR ATGEAWQ+IM
Sbjct: 1347 VALLIAMLFFIYAVIGMQVFGKVAMVDGTHINRNNNFQTFPQAVLLLFRCATGEAWQEIM 1406
Query: 3925 LSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
L+C + CDP SD Y+ G E CG +FAY YFISF+MLC+FL+INLFVAVIMDNF
Sbjct: 1407 LACVSGK--LCDPESD-YNPG--EEMTCGASFAYIYFISFYMLCAFLIINLFVAVIMDNF 1461
Query: 4105 DYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLA 4284
DYLTRDWSILGPHHL+EF R+WSEYDP+AKGRIKHLDVVTLLR+I PPLGFGKLCPHR+A
Sbjct: 1462 DYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVA 1521
Query: 4285 CKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNIDEANEQLRSAIKRIWKRTHKD 4464
CKRLV+MNMPLNSDGTV FNATLFALVRT LKI T+GN+++ANE+LR+ IK+IWKRT
Sbjct: 1522 CKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTDGNLEQANEELRAVIKKIWKRTSMK 1581
Query: 4465 LLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLR 4644
LLD+VVPPAG +D+VTVGKFYATFLIQDYFR+FKKRKE GV +Q A+ALQAGLR
Sbjct: 1582 LLDQVVPPAG-DDEVTVGKFYATFLIQDYFRKFKKRKEEGLVGVHASQNNTAIALQAGLR 1640
Query: 4645 TLHEIGPELKRAISGNLE----TDFNFDEPEPQHRRPHSLFNNLVHRLSGAGSKSPTEHE 4812
TLH+IGPE++RAIS +L+ DF +E E +RR LF N V+ ++G + + H+
Sbjct: 1641 TLHDIGPEIRRAISCDLQDDELVDFIPEEDEEIYRRNGGLFGNHVNHVNGDHHRRSSSHQ 1700
Query: 4813 RIEKGSTLLPFQPRSFS----PTHSLAGAEGSPVPSQMHRGAPINQSINLPP----VNGS 4968
L P ++ P L P+ HR N S P +N +
Sbjct: 1701 TNATQRPLQVQPPSHYAHMEQPVGGLCRGNAMSHPNHHHRHHHHNSSYGKSPKSTNINLN 1760
Query: 4969 ARRLPALPPYANHIHDETDDGPRYRDTGDRAGYDQSSRMVVANRNLPVDPDEEEQWMR-- 5142
+ +LP H H + P + GY +R P PD ++ R
Sbjct: 1761 NANVSSLPNGGGHHHRYYEHAPPPAN-----GYP-------GHRGGPYYPDYDKPPPRGT 1808
Query: 5143 -SGGPSNRSDRRNPHLREPMLVXXXXXXXXXXMSSEAYEGTYRPVGEGKSVR 5295
G S+ D R+P +R E YE G+ +S +
Sbjct: 1809 PEGQRSHVGDVRHPTIRREEEFDDDRYSAEYYSGEEFYEDDSMLSGDRRSYK 1860
>gi|42564146|gb|AAS20587.1| L-type calcium channel pore subunit
isoform 1.3b [Danio rerio]
Length = 2040
Score = 1599 bits (4141), Expect = 0.0
Identities = 859/1627 (52%), Positives = 1076/1627 (65%), Gaps = 50/1627 (3%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
NNP+R+ CI++VEWKPF+ IL I ANC+ALA+Y P+P DS+ N LET+EY F+++
Sbjct: 111 NNPVRRACINLVEWKPFDIFILLSIFANCVALAVYIPFPEDDSNSTNHDLETVEYAFLII 170
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQ----------- 546
FTIE LKIVA G + H ++Y+RN WN+LDF+IV++GL S +L ++
Sbjct: 171 FTIETFLKIVAYGLVMHQNSYVRNGWNMLDFVIVIVGLFSVVLELITKDRDVSGQSGGKP 230
Query: 547 -GFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLE 723
GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+I++AM+PLLHIALLVLFVI+IYAIIGLE
Sbjct: 231 GGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLE 290
Query: 724 LFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPG 903
LF GK+H+TC AT LA++DP PC G C + ++ G W G
Sbjct: 291 LFIGKMHATCYLSATRILAEEDPAPCSLSGHGR--HCPLNGTVCRDG----------WHG 338
Query: 904 PNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLN 1083
PNNGITNFDNF AMLTVFQC+++EGWTDV+YW+NDA+G E PW+YFV+LVI GSFFVLN
Sbjct: 339 PNNGITNFDNFLFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLN 398
Query: 1084 LVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDE 1263
LVLGVLSGEFSKEREKA+ARG FQK REKQQLEEDLKGYLDWITQAEDI+P NE+E + E
Sbjct: 399 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPDNEEEGDQE 458
Query: 1264 PVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXX 1443
+ R N +VKS FYW
Sbjct: 459 AKRNPSVXTSENESXNTENPGXDEKIFCGPFCRWRCWNRFCRRKCRAVVKSTVFYWLVIL 518
Query: 1444 XXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFD 1623
+SEHY Q +WL Q +AN + LF+ EML+KMYSLG Y S FNRFD
Sbjct: 519 LVFLNTLTISSEHYNQPDWLTEVQDVANKVLLALFTCEMLIKMYSLGLQAYFVSLFNRFD 578
Query: 1624 CFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXX 1803
CFVV I+E +LV ++M PLG+SV R RL+RIFKVT++W
Sbjct: 579 CFVVCGGIVETILVELEIMSPLGISVFRCVRLIRIFKVTRHWASLSNLVASLLNSMKSIA 638
Query: 1804 XXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQ-ILTGEDWNT 1980
GMQ+FGGKFNF+ K R+ F L ILTGEDWNT
Sbjct: 639 SLLLLLFFFIIIFSLLGMQLFGGKFNFDETVTK-RSTFRQLPSGLAHCLSGILTGEDWNT 697
Query: 1981 VMYHGIESFGGVGTLGVIVCIY---------YIVLFICGNYILLNVFLAIAVDNLADADS 2133
VMY GI ++GG + G++VCIY YI+L + + N+ A ++++ +
Sbjct: 698 VMYDGIMAYGGPSSSGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNSAQKEEE 757
Query: 2134 LTNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSA-------------RPR 2274
N +S R +
Sbjct: 758 KRNKRRKSRSMSIYKRDGDDRELKAPDDQEASRDPAEELADSSEEEEEEEPEVPSGLRAQ 817
Query: 2275 RMSEVPAASTVKPIPKASSLFILSHTNSF------RVFCNMVVNHSYFTNAVLFCILVSS 2436
R+SE+ + PIP S+ FILS++N + RV CN ++ H +N ++ I++SS
Sbjct: 818 RLSELSLREKMPPIPDGSAFFILSNSNPYVTQVLIRVLCNRLICHHILSNIIIIFIMLSS 877
Query: 2437 AMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDI 2616
LAA DP++ S RN++L YFDY F ++FTVEI +K+ FG HKG+FCR+ FNLLD+
Sbjct: 878 VSLAAADPIRNFSARNIVLGYFDYAFPAIFTVEILVKMTAFGAFLHKGAFCRSYFNLLDL 937
Query: 2617 LVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIML 2796
LVV VSL SF +++ A+S AINRAKGLKHVVQCV VA++TIGNIM+
Sbjct: 938 LVVGVSLVSFGIQSSAISVVKILRILRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMI 997
Query: 2797 VTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNN 2976
VT +LQFMFA IGVQLFKG F+ C+D +K T +C+G YI Y G+ P ++R+W N+
Sbjct: 998 VTTLLQFMFACIGVQLFKGKFYRCSDEAKSTPEDCKGTYIVYSMGETAFPQMRERLWFNS 1057
Query: 2977 DFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXX 3156
DFNFDNV AM++LF VSTFEGWP LLY AIDS++E+ GPI+N R +++
Sbjct: 1058 DFNFDNVLMAMMALFTVSTFEGWPALLYKAIDSSKENIGPIYNYRVEISIFFIIYIIIIA 1117
Query: 3157 XXXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWW 3336
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+NR QY+ W+
Sbjct: 1118 FFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNRYQYKFWY 1177
Query: 3337 FVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALN 3516
V S FEY++F++IV+NT+ LA +H SR F +DV N++FTGVFA E +LK+VA
Sbjct: 1178 VVNSTGFEYIMFVLIVLNTLCLAVQHXGQSRLFNYAMDVLNMVFTGVFAVEMILKLVAFK 1237
Query: 3517 PKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNL-ISINFFRLFRVMRLVKLLSRGEG 3693
PK+Y +D WN FD L+VVGS +DI ++N + ISI FFRLFRVMRLVKLLSRGEG
Sbjct: 1238 PKHYFADAWNTFDALIVVGSIVDIAITEINNTEDSARISITFFRLFRVMRLVKLLSRGEG 1297
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAA 3873
IRTLLWTF+KSFQALPYVALLI +LFFIYAVIGMQ FGK+A+ D TSI+RNNNF +FP A
Sbjct: 1298 IRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQVFGKIAMVDGTSINRNNNFQTFPQA 1357
Query: 3874 ILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFML 4053
+L+LFR ATGEAWQ IML+C + CD SD Y+ G E CG+NFA YFISF+ML
Sbjct: 1358 VLLLFRCATGEAWQQIMLACLPGK--LCDSESD-YNPG--EEKSCGSNFAILYFISFYML 1412
Query: 4054 CSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLR 4233
C+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+WSEYDP+AKGRIKHLDVVTLLR
Sbjct: 1413 CAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLR 1472
Query: 4234 KISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNIDEAN 4413
+I PPLGFGKLCPHR+ACKRLV+MNMPLNSDGTV FNATLFALVRT LKI TEGN+++AN
Sbjct: 1473 RIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQAN 1532
Query: 4414 EQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEMEAKG 4593
E+LR+ IK+IWK+T LLD+VVPPAG +D++TVGKFYATFLIQDYFR+F+KRKE +G
Sbjct: 1533 EELRAVIKKIWKKTSMKLLDQVVPPAG-DDEITVGKFYATFLIQDYFRKFRKRKE---QG 1588
Query: 4594 VLPAQT--PQAMALQAGLRTLHEIGPELKRAISGNLE----TDFNFDEPEPQHRRPHSLF 4755
++ Q ALQAGLRTLH+IGPE+ RAIS +L+ D N + E R +F
Sbjct: 1589 LVGGQMLFNTTTALQAGLRTLHDIGPEICRAISCDLQDEGLVDANLHDEEEMVGRNGVVF 1648
Query: 4756 NNLVHRLSGAGSKSPTEHERIEKGSTLLPFQPRS--FSPTHSLAGAEGSPVPSQMHRGAP 4929
N +SG S T+ L QP S S ++ A G + + H G
Sbjct: 1649 GN---HVSGDQFSSVTQR---PLQLPLPQSQPLSDARSSNSNINNANGPGITNGWHSGRS 1702
Query: 4930 INQSINL 4950
+ S+++
Sbjct: 1703 LVSSLSV 1709
Score = 85.9 bits (211), Expect = 1e-14
Identities = 84/288 (29%), Positives = 127/288 (43%), Gaps = 28/288 (9%)
Frame = +1
Query: 2281 SEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDP 2460
S+ +ST P+A LF L+ N R C +V F +L I + LA P
Sbjct: 90 SKKQGSSTNSRPPRA--LFCLTLNNPVRRACINLVEWKPFDIFILLSIFANCVALAVYIP 147
Query: 2461 L---QANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAV 2631
+NST N L +Y F +FT+E LK++ +GLV H+ S+ RN +N+LD ++V V
Sbjct: 148 FPEDDSNST-NHDLETVEYAFLIIFTIETFLKIVAYGLVMHQNSYVRNGWNMLDFVIVIV 206
Query: 2632 SLTSFVLR-----TDAMSXXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVA 2769
L S VL D A ++ L+ V+ +I A
Sbjct: 207 GLFSVVLELITKDRDVSGQSGGKPGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKA 266
Query: 2770 VKTIGNIMLVTFMLQFMFAIIGVQLFKG----TFFL--CNDLSKMTEAEC--RGEYIHYE 2925
+ + +I L+ + ++AIIG++LF G T +L L++ A C G H
Sbjct: 267 MVPLLHIALLVLFVIIIYAIIGLELFIGKMHATCYLSATRILAEEDPAPCSLSGHGRHC- 325
Query: 2926 DGDPTKPVSKKRVW---SNNDFNFDNVGDAMISLFVVSTFEGWPQLLY 3060
P + W +N NFDN AM+++F T EGW +LY
Sbjct: 326 ---PLNGTVCRDGWHGPNNGITNFDNFLFAMLTVFQCITMEGWTDVLY 370
>gi|37606176|emb|CAE50430.1| SI:zK70P6.5 (novel protein similar to
vertebrate voltage-dependent calcium channel P/Q type
alpha 1 subunit (CACNA1)) [Danio rerio]
Length = 1798
Score = 1573 bits (4072), Expect = 0.0
Identities = 882/1817 (48%), Positives = 1119/1817 (61%), Gaps = 78/1817 (4%)
Frame = +1
Query: 265 PFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFM 444
PF+ IL I ANC+AL + +P+P DS+ N LE +EYVF+++FTIE LKI+A G +
Sbjct: 1 PFDIFILLAIFANCVALGVSKPFPEDDSNATNHDLEQVEYVFLIIFTIETFLKILAYGLV 60
Query: 445 FHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQ-------------GFDVKALRAFRVL 585
HPS+Y+RN WN+LDF+IV++GL S +L ++ + G DVKALRAFRVL
Sbjct: 61 MHPSSYIRNGWNLLDFVIVIVGLFSVVLETVTHKSGETTSHTPGKPGGLDVKALRAFRVL 120
Query: 586 RPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPA 765
RPLRLVSGVPSLQ+VLN+I++AM+PLLHI+LLVLFVI+IYAIIGLELF G++H TC
Sbjct: 121 RPLRLVSGVPSLQIVLNSIMKAMVPLLHISLLVLFVIIIYAIIGLELFIGRMHRTCFYIG 180
Query: 766 TGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLA 945
T A DP PC G +C + S EC W GPN GITNFDNF A
Sbjct: 181 TDNYADDDPLPCAFAGHGR--QCYVNGS--------ECRGK--WEGPNGGITNFDNFFFA 228
Query: 946 MLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKER 1125
MLTVFQC+++EGWTDV+YW+NDA+G E PW+YFV+LVI GSFFVLNLVLGVLSGEFSKER
Sbjct: 229 MLTVFQCITMEGWTDVLYWMNDAIGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKER 288
Query: 1126 EKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQED---EPVAQTXXXXXX 1296
EKA+ARG FQK REKQQ+EEDL GY+DWITQAEDI+ +ED +A
Sbjct: 289 EKAKARGDFQKLREKQQMEEDLCGYMDWITQAEDIDEFDEDGNRRVTLRDLADKKRGKFG 348
Query: 1297 XXXXXXXXXXXXPSKWAAR--------------------------MKRLEKLNXXXXXXX 1398
P+ A + L + N
Sbjct: 349 WFSHSNETHASLPASETASENTENIDEEHTDCCAACCARIMKIPCCRALRRWNRCIRRNC 408
Query: 1399 XXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYS 1578
VKS TFYW SEHY Q EWL Q +AN + LF++EMLLKMYS
Sbjct: 409 RTAVKSVTFYWLVLILVFLNTALSASEHYNQPEWLTDVQDIANKVLLSLFTVEMLLKMYS 468
Query: 1579 LGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXX 1758
LG Y + FNRFDCFVV ILE VLV ++M PLG+SVLR RLLRIFKVT++WT
Sbjct: 469 LGLQVYFVAFFNRFDCFVVCGGILETVLVEMEIMPPLGISVLRCVRLLRIFKVTRHWTAL 528
Query: 1759 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQAL 1938
GMQ+FGGKFNF+ Q K R+ FD+F QAL
Sbjct: 529 SNLVASLLNSMKSIASLLLLLFLFLIIFALLGMQLFGGKFNFDETQTK-RSTFDSFPQAL 587
Query: 1939 LTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNL 2118
LT FQILTGEDWN VMY GI ++GG G+IVC+Y+++LFIC ILLNVFLAIAVDNL
Sbjct: 588 LTCFQILTGEDWNVVMYDGIMAYGGPVFPGMIVCLYFVILFICD--ILLNVFLAIAVDNL 645
Query: 2119 A--DADSLTNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSARPRRMSEVP 2292
A D D+ N E
Sbjct: 646 AGGDGDNKKNEEKKEGEAEPAEEENGEVKVDMDEEYE--------------EEEEPEEGD 691
Query: 2293 AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN 2472
+ PIP+ S+ F LS TN RV C+ +++H FTN +L I++SS LAAEDP++A+
Sbjct: 692 DEEKILPIPEGSAFFCLSKTNPIRVGCHTLIHHHIFTNLILVFIILSSISLAAEDPIRAH 751
Query: 2473 STRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL 2652
S RN +L Y DY FTS+FTVEI LK+ V G H+GSFCRN FNLLD+LVV+VSL SF L
Sbjct: 752 SFRNNVLGYADYAFTSIFTVEILLKMTVHGAFLHEGSFCRNWFNLLDLLVVSVSLVSFFL 811
Query: 2653 RTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAII 2832
+ A+S AINRAKGLKHVVQCV VA++TIGNIM+VT +LQFMFA I
Sbjct: 812 HSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACI 871
Query: 2833 GVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMI 3012
GVQLFKG F+ C D +K T +C+G ++ Y+DGD + P+ ++R+W N+DFNFDNV M+
Sbjct: 872 GVQLFKGKFYRCTDEAKNTPEQCKGTFVVYKDGDVSHPMVRERIWLNSDFNFDNVLMGMM 931
Query: 3013 SLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVI 3192
+LF VSTFEGWP LLY AID+N E+ GPI+N R +++ GFVI
Sbjct: 932 ALFTVSTFEGWPALLYKAIDANGENHGPIYNYRVEISIFFIVYIIIIAFFMMNIFVGFVI 991
Query: 3193 VTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVTSRAFEYVIF 3372
+TF+ +GE E++NCELDKNQR+C+E+ALKA+P + YIP+N +QY+ W + S FEYV+F
Sbjct: 992 ITFREQGEAEFKNCELDKNQRQCVEYALKAQPLKLYIPKNPVQYKFWSIINSTGFEYVMF 1051
Query: 3373 LIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVF 3552
++I++NTV+LA +HY S+ F +D+ N++FTG+F E ++K++AL ++Y D WN F
Sbjct: 1052 VLILLNTVTLAVQHYDQSKFFSQVMDILNMVFTGLFTVEMIIKLMALRLRHYFVDAWNSF 1111
Query: 3553 DLLVVVGSFIDITYGKLNPG-GTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSF 3729
D L+VVGS +DI + + ++ +SI FFRLFRVMRLVKLLS+GEGIRTLLWTF+KS
Sbjct: 1112 DALIVVGSVVDIVVTEFSSSEDSSRVSITFFRLFRVMRLVKLLSKGEGIRTLLWTFVKSL 1171
Query: 3730 QALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEA 3909
QALPYVALLI ++FFIYAVIGMQ FGK+A+ D T I+RNNNF +FP A+L+LFR ATGEA
Sbjct: 1172 QALPYVALLIAMIFFIYAVIGMQTFGKIAMQDHTQINRNNNFQTFPQAVLLLFRCATGEA 1231
Query: 3910 WQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAV 4089
WQ+IML+ + RCD SD + G E CG+N A YFISFFMLC+FL+INLFVAV
Sbjct: 1232 WQEIMLASLPGK--RCDAESD-FEPG--EEFSCGSNIAIVYFISFFMLCAFLIINLFVAV 1286
Query: 4090 IMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLC 4269
IMDNFDYLTRDWSILGPHHL+EF R+WSEYDP+AKGRIKHLDVV LLR+I PPLGFGKLC
Sbjct: 1287 IMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVALLRRIQPPLGFGKLC 1346
Query: 4270 PHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNIDEANEQLRSAIKRIWK 4449
PHR+ACKRLV+MNMPLN+DGTV FNATLFALVRT LKI T+GN D+ NE+LR IK+IWK
Sbjct: 1347 PHRVACKRLVAMNMPLNADGTVTFNATLFALVRTALKIKTDGNPDQENEELRIIIKKIWK 1406
Query: 4450 RTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEMEAKGVLPAQTPQAMAL 4629
RT +LDEV+PP E++VTVGKFYATFLIQDYFR+F+KRK E G+ AL
Sbjct: 1407 RTKPKVLDEVIPPPA-EEEVTVGKFYATFLIQDYFRKFRKRK--EKVGLEEEGNGNPTAL 1463
Query: 4630 QAGLRTLHEIGPELKRAISGNLETDFNFDEPEPQHRRP---------------HSLFNNL 4764
QAGLRTL E+GPE++ +G T EP + RR + N
Sbjct: 1464 QAGLRTLQELGPEMRLNENGYAHT-----EPLSRSRRSSLATTPIGAPVPVPGDGILNGG 1518
Query: 4765 VHRLS-------GAGSKSPTEHERIEKGSTLLPFQPR-------SFSPTHSLAGAEGSPV 4902
+ R S G G+ R + + + +Q + + ++ P+
Sbjct: 1519 LGRRSSLAKTPNGNGALENENFRRRDSMRSSIHYQHKNGRKASFNIQCLRRQGSSDDLPI 1578
Query: 4903 PSQMHRGAPINQSINLPPVNGSARRLPALPPYANHIHDETDDGPRYRDTGDRAGYDQSSR 5082
P H+ N PP ++ + + T + +TG R G R
Sbjct: 1579 PGTYHQ--------NSPPCRARSQGYSSYDSRRSSARSSTGSTASWANTGPRRG-----R 1625
Query: 5083 MVVANRNLPVDPDEEEQWMRSGGPSNRSDRRNPHLREPMLVXXXXXXXXXXMSSEAYEGT 5262
++ A P+ EEE +GG D++ + P V S + G
Sbjct: 1626 LLYA----PLILVEEEGAAGAGG-VGIWDKKPGGVGVPASV---RHPGSGWYSGPSAGGG 1677
Query: 5263 YRPVGEGKSVRLPFSSRPVLRPAEDSRPVDRLIGQSL---GLGRYA-DARIVGAARREIE 5430
+P ++R+P P +E D L+ L GLG YA D + V A+REI
Sbjct: 1678 GQPYRAYTTLRVPTQLSP--HYSEKRGSADSLVEAVLISEGLGLYAKDPKFVAFAKREIA 1735
Query: 5431 EAYSLGEQEIDLAADSL 5481
+A + E++ AA L
Sbjct: 1736 DACHMTIDEMESAASDL 1752
Score = 126 bits (317), Expect = 5e-27
Identities = 96/333 (28%), Positives = 161/333 (47%), Gaps = 9/333 (2%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR C +++ F LIL I + I+LA P A ++N +L +Y F +F
Sbjct: 712 NPIRVGCHTLIHHHIFTNLILVFIILSSISLAAEDPIRAHS--FRNNVLGYADYAFTSIF 769
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
T+E +LK+ G H ++ RN +N+LD ++V + LVS L +I VK LR RV
Sbjct: 770 TVEILLKMTVHGAFLHEGSFCRNWFNLLDLLVVSVSLVSFFLHSSAIS--VVKILRVLRV 827
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLR ++ L+ V+ + A+ + +I ++ + ++A IG++LF GK + C D
Sbjct: 828 LRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFY-RCTDE 886
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
A+ P C F +++ VR N+ + NFDN +
Sbjct: 887 -----AKNTPEQC-----KGTFVVYKDGDVSHPMVRERIWLNSDF--------NFDNVLM 928
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIY---------FVTLVILGSFFVLNLVLG 1095
M+ +F + EGW ++Y DA G IY F+ +I+ +FF++N+ +G
Sbjct: 929 GMMALFTVSTFEGWPALLYKAIDANGENHGPIYNYRVEISIFFIVYIIIIAFFMMNIFVG 988
Query: 1096 VLSGEFSKEREKARARGLFQKFREKQQLEEDLK 1194
+ F +E+ +A + ++Q +E LK
Sbjct: 989 FVIITF-REQGEAEFKNCELDKNQRQCVEYALK 1020
Score = 90.9 bits (224), Expect = 3e-16
Identities = 72/317 (22%), Positives = 139/317 (43%), Gaps = 20/317 (6%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP++ SI+ FE+++ +I N + LA+ Q Y S + + +++ + VF +F
Sbjct: 1031 NPVQYKFWSIINSTGFEYVMFVLILLNTVTLAV-QHY--DQSKFFSQVMDILNMVFTGLF 1087
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG----FDVKALR 570
T+E ++K++A+ Y +AWN D +IVV +V ++++ S + R
Sbjct: 1088 TVEMIIKLMALRLRH----YFVDAWNSFDALIVVGSVVDIVVTEFSSSEDSSRVSITFFR 1143
Query: 571 AFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHST 750
FRV+R ++L+S ++ +L ++++ L ++ALL+ + IYA+IG++ F
Sbjct: 1144 LFRVMRLVKLLSKGEGIRTLLWTFVKSLQALPYVALLIAMIFFIYAVIGMQTF------- 1196
Query: 751 CIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFD 930
G++A +D T N NF
Sbjct: 1197 ------GKIAMQDHTQI------------------------------------NRNNNFQ 1214
Query: 931 NFGLAMLTVFQCVSLEGWTDVMY----------------WVNDAVGREWPWIYFVTLVIL 1062
F A+L +F+C + E W ++M + G +YF++ +L
Sbjct: 1215 TFPQAVLLLFRCATGEAWQEIMLASLPGKRCDAESDFEPGEEFSCGSNIAIVYFISFFML 1274
Query: 1063 GSFFVLNLVLGVLSGEF 1113
+F ++NL + V+ F
Sbjct: 1275 CAFLIINLFVAVIMDNF 1291
>gi|27801609|emb|CAD60650.1| SI:dZ223C6.1 (novel protein similar to
human voltage-dependent calcium channel L type, alpha 1D
subunit (CACNA1D)) [Danio rerio]
Length = 1374
Score = 1310 bits (3391), Expect = 0.0
Identities = 700/1310 (53%), Positives = 852/1310 (64%), Gaps = 80/1310 (6%)
Frame = +1
Query: 1108 EFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVAQTXXX 1287
EFSKEREKA+ARG FQK REKQQLEEDLKGYLDWITQAEDI+P NE+E+E+ +
Sbjct: 1 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEEEESKRNRVTLA 60
Query: 1288 XXXXXXXXXXXXXXXPSKWAARM---------------------------KRLEKLNXXX 1386
S A M +R + N
Sbjct: 61 SLMEKKKKGFGWFSQSSDTHASMPASETESMNTENEKGEDEKATCCGPTCRRWRRWNRLC 120
Query: 1387 XXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLL 1566
VKS FYW +SEHY Q WL Q +AN + +F+ EML+
Sbjct: 121 RRNCRLAVKSVPFYWLVIILVFLNTLTISSEHYNQPMWLTQVQDVANKVLLAMFTCEMLV 180
Query: 1567 KMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKY 1746
KMYSLG Y S FNRFDCFVV I E +LV F++M PLG+SV R RLLRIFKVT++
Sbjct: 181 KMYSLGLQAYFVSLFNRFDCFVVCGGITETILVEFEIMSPLGISVFRCVRLLRIFKVTRH 240
Query: 1747 WTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTF 1926
W GMQVFGGKFNF+ Q K R+ FD F
Sbjct: 241 WASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQVFGGKFNFDETQTK-RSTFDNF 299
Query: 1927 VQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIA 2106
QALLTVFQILTGEDWN VMY GI ++GG + G+IVCIY+I+LFICGNYILLNVFLAIA
Sbjct: 300 PQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIA 359
Query: 2107 VDNLADADSLTNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSARPRRMSE 2286
VDNLADA+SL + + RR
Sbjct: 360 VDNLADAESLNT--------------------------------DDTKKPSQSLLRRRRS 387
Query: 2287 VPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQ 2466
+ + V+ A T + RV C+ ++NH FTN +L I++SSA LAAEDP++
Sbjct: 388 LQSQRAVRSSSSA--------TQTLRVACHKLINHHIFTNLILVFIMLSSASLAAEDPIR 439
Query: 2467 ANSTRNMILNYFDYFFTSVFTVEITLKVI--------------------VFGLVFHKGSF 2586
S RN+IL YFDY FT++FTVEI LKV+ +G HKG+F
Sbjct: 440 NFSARNIILGYFDYAFTAIFTVEIVLKVLGYADYVFTSMFTFEIVLKMTTYGAFLHKGAF 499
Query: 2587 CRNAFNLLDILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIV 2766
CRN FNLLD+LVV VSL SF +++ A+S AINRAKGLKHVVQCV V
Sbjct: 500 CRNYFNLLDLLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFV 559
Query: 2767 AVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKP 2946
A++TIGNIM+VT +LQFMFA IGVQLFKG F+ CND +K + EC+G YI Y++GD +P
Sbjct: 560 AIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCNDEAKSSPEECKGTYIMYKEGDVNQP 619
Query: 2947 VSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVAL 3126
+ +KR W N+DFNFDNV AM++LF VSTFEGWP LLY AIDSN E+ GPI+N R +++
Sbjct: 620 IIQKRHWHNSDFNFDNVLMAMMALFTVSTFEGWPALLYKAIDSNRENMGPIYNYRVEISI 679
Query: 3127 XXXXXXXXXXXXXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIP 3306
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP
Sbjct: 680 FFIIYIIIIAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIP 739
Query: 3307 RNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAF 3486
+N QY+ W+ V S FEY++F++I++NT+ LA +HY S F +D+ N++FT VF
Sbjct: 740 KNPYQYKFWYVVNSTGFEYIMFVLILLNTICLAVQHYGQSELFNYVMDILNMVFTAVFTV 799
Query: 3487 EAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKL--------------------- 3603
E VLK++A P+ Y D WNVFD LVV+GS +DI ++
Sbjct: 800 EMVLKLIAFKPRGYFGDAWNVFDALVVIGSIVDIVLSEIDHYFTDAWNTFDALIVVGSVV 859
Query: 3604 --------NPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLI 3759
N + ISI FFRLFRVMRLVKLLSRGEGIRTLLWTF+KSFQALPYVALLI
Sbjct: 860 DIAITEVNNTEDSARISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLI 919
Query: 3760 VLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSD 3939
+LFFIYAVIGMQ FGK+A+ D T I+RNNNF +FP A+L+LFR ATGEAWQ+IML+C
Sbjct: 920 AMLFFIYAVIGMQVFGKIAMVDHTQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACMP 979
Query: 3940 REDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTR 4119
+ CDP SD Y+ G E CG++FA YFI+F+MLC+FL+INLFVAVIMDNFDYLTR
Sbjct: 980 GK--LCDPESD-YNPG--EEMTCGSSFAIIYFITFYMLCAFLIINLFVAVIMDNFDYLTR 1034
Query: 4120 DWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLV 4299
DWSILGPHHL+EF R+WSEYDP+AKGRIKHLDVVTLLR+I PPLGFGKLCPHR+ACKRLV
Sbjct: 1035 DWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLV 1094
Query: 4300 SMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEV 4479
+MNMPLNSDGTV FNATLFALVRT LKI TEGN+++ANE+LR+ IK+IWKRT LLD+V
Sbjct: 1095 AMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKRTSMKLLDQV 1154
Query: 4480 VPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEI 4659
VPPAG +D+VTVGKFYATFLIQDYFR+FKKRKE GV PAQ A+ALQAGLRTLH+I
Sbjct: 1155 VPPAG-DDEVTVGKFYATFLIQDYFRKFKKRKEEGLVGVHPAQNNTAIALQAGLRTLHDI 1213
Query: 4660 GPELKRAISGNLE----TDFNFDEPEPQHRRPHSLFNNLVHRLSGAGSKS 4797
GPE++RAIS +L+ DF +E E +RR LF N ++ ++G +S
Sbjct: 1214 GPEIRRAISCDLQDDELVDFIPEEDEEIYRRNGGLFGNHINHINGDPRRS 1263
Score = 115 bits (289), Expect = 9e-24
Identities = 95/359 (26%), Positives = 164/359 (45%), Gaps = 28/359 (7%)
Frame = +1
Query: 139 KRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIALA 318
K+P+Q LR+ + +R C ++ F LIL I + +LA
Sbjct: 375 KKPSQSL-LRRRRSLQSQRAVRSSSSATQTLRVACHKLINHHIFTNLILVFIMLSSASLA 433
Query: 319 IYQP---YPAQDS-----DYKNTLLETIE----------YVFIVVFTIECVLKIVAMGFM 444
P + A++ DY T + T+E YVF +FT E VLK+ G
Sbjct: 434 AEDPIRNFSARNIILGYFDYAFTAIFTVEIVLKVLGYADYVFTSMFTFEIVLKMTTYGAF 493
Query: 445 FHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQ 624
H A+ RN +N+LD ++V + LVS + +I VK LR RVLRPLR ++ L+
Sbjct: 494 LHKGAFCRNYFNLLDLLVVGVSLVSFGIQSSAIS--VVKILRVLRVLRPLRAINRAKGLK 551
Query: 625 VVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCG 804
V+ + A+ + +I ++ + ++A IG++LF GK + C
Sbjct: 552 HVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYR-----------------CN 594
Query: 805 TDTEGSAFKCQPSDSLTNMG-VRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEG 981
+ + S +C+ + + G V W +N NFDN +AM+ +F + EG
Sbjct: 595 DEAKSSPEECKGTYIMYKEGDVNQPIIQKRHW---HNSDFNFDNVLMAMMALFTVSTFEG 651
Query: 982 WTDVMYWVNDA----VGREWPW-----IYFVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
W ++Y D+ +G + + I+F+ +I+ +FF++N+ +G + F ++ EK
Sbjct: 652 WPALLYKAIDSNRENMGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEK 710
Score = 92.4 bits (228), Expect = 1e-16
Identities = 81/345 (23%), Positives = 142/345 (40%), Gaps = 48/345 (13%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP + +V FE+++ +I N I LA+ Q Y S+ N +++ + VF VF
Sbjct: 741 NPYQYKFWYVVNSTGFEYIMFVLILLNTICLAV-QHYG--QSELFNYVMDILNMVFTAVF 797
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD--------- 555
T+E VLK++A F P Y +AWN+ D ++V+ +V +LS++ D
Sbjct: 798 TVEMVLKLIA----FKPRGYFGDAWNVFDALVVIGSIVDIVLSEIDHYFTDAWNTFDALI 853
Query: 556 -----------------------VKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLL 666
+ R FRV+R ++L+S ++ +L +++ L
Sbjct: 854 VVGSVVDIAITEVNNTEDSARISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALP 913
Query: 667 HIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSD 846
++ALL+ + IYA+IG+++F G++A D T
Sbjct: 914 YVALLIAMLFFIYAVIGMQVF-------------GKIAMVDHTQI--------------- 945
Query: 847 SLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVM---------- 996
N NF F A+L +F+C + E W ++M
Sbjct: 946 ---------------------NRNNNFQTFPQAVLLLFRCATGEAWQEIMLACMPGKLCD 984
Query: 997 ----YWVNDAV--GREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
Y + + G + IYF+T +L +F ++NL + V+ F
Sbjct: 985 PESDYNPGEEMTCGSSFAIIYFITFYMLCAFLIINLFVAVIMDNF 1029
Score = 67.4 bits (163), Expect = 4e-09
Identities = 70/303 (23%), Positives = 123/303 (40%), Gaps = 10/303 (3%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALA---IYQP-YPAQDSDYKNTLLETIEYV 387
N R+ C V+ PF +L++ ++ N + ++ QP + Q D N +L
Sbjct: 117 NRLCRRNCRLAVKSVPFYWLVIILVFLNTLTISSEHYNQPMWLTQVQDVANKVL------ 170
Query: 388 FIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG-FDVKA 564
+ +FT E ++K+ ++G AY + +N D +V G+ TIL + I +
Sbjct: 171 -LAMFTCEMLVKMYSLGLQ----AYFVSLFNRFDCFVVCGGITETILVEFEIMSPLGISV 225
Query: 565 LRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLH 744
R R+LR ++ SL ++ ++L +M + + LL+ I+I++++
Sbjct: 226 FRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLL---------- 275
Query: 745 STCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITN 924
G G F + + +
Sbjct: 276 -------------------GMQVFGGKFNFDETQTKRS---------------------T 295
Query: 925 FDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWP-----WIYFVTLVILGSFFVLNLV 1089
FDNF A+LTVFQ ++ E W VMY A G IYF+ L I G++ +LN+
Sbjct: 296 FDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVF 355
Query: 1090 LGV 1098
L +
Sbjct: 356 LAI 358
>gi|47229178|emb|CAG03930.1| unnamed protein product [Tetraodon
nigroviridis]
Length = 2028
Score = 1263 bits (3269), Expect = 0.0
Identities = 717/1640 (43%), Positives = 953/1640 (57%), Gaps = 155/1640 (9%)
Frame = +1
Query: 262 KPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGF 441
+PF+ IL I ANC+A+ + +PYP DS+ N LE +EYVF+V+FTIE KI+A G
Sbjct: 2 RPFDIFILLAIFANCVAMGVTKPYPDDDSNATNHKLEQVEYVFLVIFTIETFTKILAYGL 61
Query: 442 MFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQ-------------GFDVKALRAFRV 582
+ HPSAY+R+ WN+LDFIIV++GL S I M+ G DVKALRAFRV
Sbjct: 62 VMHPSAYIRSGWNLLDFIIVIVGLFSVIAEGMTDHKPGEAHHAAGKPGGLDVKALRAFRV 121
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLRLVSGVPSLQ+VLN+I++AM+PLLHI +LV+FVI+IYAIIGLELF G++H TC
Sbjct: 122 LRPLRLVSGVPSLQIVLNSIMKAMVPLLHIGMLVMFVIIIYAIIGLELFIGRMHKTCYST 181
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
TG + + DP+PC GS C + + EC W GPN GITNFDN
Sbjct: 182 TTGLMMEDDPSPCAF--AGSGRFCVENGT--------ECRGK--WEGPNGGITNFDNIFF 229
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLS------ 1104
AMLTVFQC+++EGWTDV+YW+NDA+G E PWIYFV+LVI GSFF++NLVLGVLS
Sbjct: 230 AMLTVFQCITMEGWTDVLYWMNDAIGYEIPWIYFVSLVIFGSFFIINLVLGVLSGEFSKE 289
Query: 1105 -------GEFSKEREKARAR----GLFQKFREKQQLEED-----------LKGYLDWITQ 1218
GE K +E + G E + ++E+ + W
Sbjct: 290 REKAVARGELQKAQESKQMEEDMIGYMDWLIEAEDVDEEGNKRAAIAKKKMMKKFGWYKH 349
Query: 1219 AED-----------------IEPVNEDEQEDEPVAQTXXXXXXXXXXXXXXXXXXPSK-- 1341
+ED PV+ + E Q P
Sbjct: 350 SEDGGGRPAPAAEPHRLLRAPSPVSLLFRRGEDDGQQFLVSKQSRRTFGAETLLHPPGNL 409
Query: 1342 -WAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQT 1518
+ +L +LN VK+ FYW SEHYGQ +WL Q
Sbjct: 410 VLSLFSDQLCQLNHTMRKNCRVAVKTTNFYWLVLLLVFLNTVASASEHYGQPKWLTEMQE 469
Query: 1519 MANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVS 1698
AN ++LF++EML+KMY+ G Y + FNRFDCFVV ILE +LV +++ P+G++
Sbjct: 470 RANKVLLLLFTLEMLMKMYAFGLQIYFMALFNRFDCFVVCGGILEMLLVELEVIPPIGIA 529
Query: 1699 VLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF 1878
VLR RLLRIFK+T++W GMQ+FGGKF
Sbjct: 530 VLRCIRLLRIFKMTRHWAALSDLVNSLLNSMKAICSLLLLLFLFLIIFALLGMQLFGGKF 589
Query: 1879 NFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVL 2058
NF+ Q K R+ FD+F QALLT FQILTGEDWN VMY GI ++GG ++VCIY+++L
Sbjct: 590 NFDETQMK-RSTFDSFPQALLTCFQILTGEDWNAVMYDGIMAYGGPIFPNMVVCIYFVIL 648
Query: 2059 FICGNYILLNVFLAIAVDNLADADSLTNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 2238
F+CGNYILLNVFLAIAVDNLA
Sbjct: 649 FVCGNYILLNVFLAIAVDNLAGGGGKNKVEEKKEEEEEWDDDEEKEDEDAGVDDLYSLHP 708
Query: 2239 XXXXXMTSARPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLF 2418
+ +P + PIP SS FIL N RV C+ +++H YFTN +L
Sbjct: 709 PLSAGVAPLKPDFSGP---KEKIVPIPDGSSFFILGKKNCLRVACHNLIHHPYFTNFILI 765
Query: 2419 CILVSSAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNA 2598
I++SS LAAEDP++++S RN++L Y DY FTSVFTVEI LK+ V+G H GSFCRNA
Sbjct: 766 FIILSSISLAAEDPIKSHSFRNIVLGYADYVFTSVFTVEIILKMTVYGAFLHTGSFCRNA 825
Query: 2599 FNLLDILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKT 2778
FNLLD+LVV+VSLTSF L + A+S AINRAKGLK+VVQCV VA++T
Sbjct: 826 FNLLDLLVVSVSLTSFFLHSSAISVVKILRVLRVLRPLRAINRAKGLKNVVQCVFVAIRT 885
Query: 2779 IGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKK 2958
IGNI++VT +LQFMFA IGVQLFKG F+ C D +K T EC+G ++ Y+DGD + P+ ++
Sbjct: 886 IGNILIVTTLLQFMFACIGVQLFKGRFYSCTDEAKHTPEECKGTFVIYKDGDISHPMVRE 945
Query: 2959 RVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXX 3138
RVW N+DFNFDNV + M++LF VSTFEGWPQLLY A+D+N ++GPI+N R +++
Sbjct: 946 RVWENSDFNFDNVLNGMLALFTVSTFEGWPQLLYRAVDANAINRGPIYNYRVEISIFFII 1005
Query: 3139 XXXXXXXXXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRL 3318
GFVI+TF+ +GE E++NCEL+KNQR+C+ +ALKA+P + YIP+N+
Sbjct: 1006 YIIIIAFFMMNIFVGFVIITFREQGEAEFKNCELNKNQRQCVYYALKAQPIKIYIPKNQS 1065
Query: 3319 QYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVL 3498
Q + W + S FEY++F++I+ NT++LA + P + + V +F L
Sbjct: 1066 QLKFWKIINSSQFEYIMFVLILGNTLTLAVQVSPPRAAPFLRVRTHQPPLSAVLSFRQAL 1125
Query: 3499 KIVAL------NPKNYISDRWNVFDLLVVVGS--------FIDITYGKLNPGGTNLISIN 3636
+ V +P++ + ++ D GS I +L+ G + +
Sbjct: 1126 RAVQALHLRHGHPQHDLHRGFHRGDDRQAAGSARPREAPPTFKINPPRLSAGPQAHLDLV 1185
Query: 3637 F---------FRLFRVMRLV---------KLLSRGEGIRTLLWTFMKSFQALPYVALL-- 3756
F + F + +V + +GE + + TF + F+ L V LL
Sbjct: 1186 FPLQHYFIDPWNSFDALIVVGSVLDIAVSEFSGKGESGKVSI-TFFRLFRVLRLVKLLSK 1244
Query: 3757 --------------IVLLFFIYAVIGMQFF----------GKVALDDSTSIHRNNNFHSF 3864
+ L ++ +I M FF GKVA+DD+T I+RN NF +F
Sbjct: 1245 GEGIRTLLWTFVKSLQALPYVGLLIAMIFFIYAVIGMQMFGKVAIDDNTDINRNCNFQTF 1304
Query: 3865 PAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISF 4044
A+LVLFR ATGE WQ+IML RCDP S D G E CG+N AY YFISF
Sbjct: 1305 FMAVLVLFRCATGEQWQEIMLGALPGR--RCDPES-DIEPG--EEYTCGSNLAYLYFISF 1359
Query: 4045 FMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVT 4224
FMLC++L+INLF+AVIMDNF+YLTRDW++LG HHL+EF R+WS+YDP+A GRIKH+DVVT
Sbjct: 1360 FMLCAYLIINLFIAVIMDNFEYLTRDWTVLGTHHLDEFKRVWSDYDPEATGRIKHIDVVT 1419
Query: 4225 LLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTE---- 4392
+LR+I PPLGFGKLCPHR+ACKRLV MN+PL+ DGTV FNATLFALVRT+LKI TE
Sbjct: 1420 MLRRIQPPLGFGKLCPHRVACKRLVDMNVPLHPDGTVTFNATLFALVRTSLKIKTEGLTP 1479
Query: 4393 --------------------------------GNIDEANEQLRSAIKRIWKRTHKDLLDE 4476
G ID+ NE+L+ IK++WKRT L+DE
Sbjct: 1480 PPPTHTHTHTHTHRLGLWVLCLLDGATRSSSSGPIDQQNEELKLIIKKLWKRTKPKLIDE 1539
Query: 4477 VVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHE 4656
V+PP + D+VT GKFYA+FLIQDYF++F+KRKE E K + +A ALQ G+R+L +
Sbjct: 1540 VIPPP-RGDEVTCGKFYASFLIQDYFKKFRKRKERERKS---KKKDRAAALQQGVRSLQD 1595
Query: 4657 IGPELKRAISGNLETDFNFD 4716
+ PE++ A++ +LE + D
Sbjct: 1596 LAPEMRLAMASDLEDEEGAD 1615
Score = 122 bits (306), Expect = 1e-25
Identities = 90/311 (28%), Positives = 149/311 (46%), Gaps = 9/311 (2%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
N +R C +++ F IL I + I+LA P + ++N +L +YVF VF
Sbjct: 744 NCLRVACHNLIHHPYFTNFILIFIILSSISLAAEDPIKSHS--FRNIVLGYADYVFTSVF 801
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
T+E +LK+ G H ++ RNA+N+LD ++V + L S L +I VK LR RV
Sbjct: 802 TVEIILKMTVYGAFLHTGSFCRNAFNLLDLLVVSVSLTSFFLHSSAIS--VVKILRVLRV 859
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLR ++ L+ V+ + A+ + +I ++ + ++A IG++LF G+ +S C D
Sbjct: 860 LRPLRAINRAKGLKNVVQCVFVAIRTIGNILIVTTLLQFMFACIGVQLFKGRFYS-CTDE 918
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
A+ P C F +++ VR W N NFDN
Sbjct: 919 -----AKHTPEEC-----KGTFVIYKDGDISHPMVR-----ERVW---ENSDFNFDNVLN 960
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDAVG---------REWPWIYFVTLVILGSFFVLNLVLG 1095
ML +F + EGW ++Y DA R I+F+ +I+ +FF++N+ +G
Sbjct: 961 GMLALFTVSTFEGWPQLLYRAVDANAINRGPIYNYRVEISIFFIIYIIIIAFFMMNIFVG 1020
Query: 1096 VLSGEFSKERE 1128
+ F ++ E
Sbjct: 1021 FVIITFREQGE 1031
>gi|31219201|ref|XP_316767.1| ENSANGP00000001382 [Anopheles gambiae]
gi|30175599|gb|EAA12018.2| ENSANGP00000001382 [Anopheles gambiae str.
PEST]
Length = 1599
Score = 1165 bits (3014), Expect = 0.0
Identities = 580/840 (69%), Positives = 674/840 (80%), Gaps = 6/840 (0%)
Frame = +1
Query: 2263 ARPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAM 2442
ARPRRMSE+ +T+ PIP S+ FILS TN FR+FC+ + NHS F N +L CI+ SSAM
Sbjct: 757 ARPRRMSELNVINTILPIPDGSAFFILSKTNRFRIFCHWLCNHSTFGNIILVCIMFSSAM 816
Query: 2443 LAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILV 2622
LAAEDPL ANS RN ILNYFDYFFTSVFT+E+ LK++ +G +FH G+FCR+AFNLLD+LV
Sbjct: 817 LAAEDPLNANSERNQILNYFDYFFTSVFTIELLLKLVSYGFLFHDGAFCRSAFNLLDLLV 876
Query: 2623 VAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVT 2802
V VSL S + A+S AINRAKGLKHVVQCVIVAVKTIGNI+LVT
Sbjct: 877 VCVSLISMFFSSGAISVIKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVT 936
Query: 2803 FMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDF 2982
+LQFMFA+IGVQL+KG FF C+D SKM E+EC G Y+ YEDG+ KPVSK+R WS N F
Sbjct: 937 CLLQFMFAVIGVQLYKGKFFSCSDGSKMQESECHGTYLVYEDGNVDKPVSKERYWSRNRF 996
Query: 2983 NFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXX 3162
+FD+V AM++LF VSTFEGWP LLYV+IDS+EED GPIHN R VA
Sbjct: 997 HFDDVSKAMLTLFTVSTFEGWPGLLYVSIDSHEEDSGPIHNFRPIVAAYYIIYIIIIAFF 1056
Query: 3163 XXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFV 3342
GFVIVTFQNEGE+EY+NC+LDKNQR CIEFALKAKP RRYIP++R+QY+VWWFV
Sbjct: 1057 MVNIFVGFVIVTFQNEGEQEYKNCDLDKNQRNCIEFALKAKPIRRYIPKHRIQYKVWWFV 1116
Query: 3343 TSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPK 3522
TS+ FEY+IF++I++NT++L+ K Y + + LD+ NLIFT VFA E V K+ A K
Sbjct: 1117 TSQPFEYMIFVLIMINTITLSMKFYRQPEIYTEVLDLLNLIFTAVFALEFVFKLAAFRFK 1176
Query: 3523 NYISDRWNVFDLLVVVGSFIDITYGKLN-----PGGTNLISINFFRLFRVMRLVKLLSRG 3687
NY D WNVFD ++V+GSFIDI Y ++N GG+++ISINFFRLFRVMRLVKLL+RG
Sbjct: 1177 NYFGDAWNVFDFIIVLGSFIDIVYSEVNISKGMKGGSSIISINFFRLFRVMRLVKLLARG 1236
Query: 3688 EGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFP 3867
EGIRTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+A+DD TSIHRNNNF +FP
Sbjct: 1237 EGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAMDDETSIHRNNNFQTFP 1296
Query: 3868 AAILVLFRSATGEAWQDIMLSCSDRE-DVRCDPMSDDYHKGGLNESRCGNNFAYPYFISF 4044
A+LVLFRSATGEAWQDIML CS R +V CD SDD G E CG+N A+PYFISF
Sbjct: 1297 QAVLVLFRSATGEAWQDIMLDCSSRPGEVNCDAKSDD---AGSPEG-CGSNIAFPYFISF 1352
Query: 4045 FMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVT 4224
++LCSFL+INLFVAVIMDNFDYLTRDWSILGPHHL+EFVRLWSEYDPDAKGRIKHLDVVT
Sbjct: 1353 YVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFVRLWSEYDPDAKGRIKHLDVVT 1412
Query: 4225 LLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNID 4404
LLRKISPPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFA+VRT+LKI TEGNID
Sbjct: 1413 LLRKISPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVLFNATLFAVVRTSLKIKTEGNID 1472
Query: 4405 EANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEME 4584
+AN +LR+ IK+IWKRT+ LLD+VVPP G +D+VTVGKFYATFLIQDYFRRFKKRKE +
Sbjct: 1473 DANAELRNTIKQIWKRTNPKLLDQVVPPPGVDDEVTVGKFYATFLIQDYFRRFKKRKEND 1532
Query: 4585 AKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDEPEPQHRRPHSLFNNL 4764
+K + M LQAGLRTLHE GPELKRAISGNLE + D PEP HRR H+LF N+
Sbjct: 1533 SKLNSDQNKRRTMTLQAGLRTLHEAGPELKRAISGNLE-EIGDDNPEPSHRRNHTLFGNV 1591
Score = 751 bits (1939), Expect = 0.0
Identities = 381/639 (59%), Positives = 448/639 (69%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+RKLCI+IVEWKPFE+LIL I ANC+ALA+Y P+P DS+ N LE IEY+F+V+F
Sbjct: 47 NPLRKLCIAIVEWKPFEYLILLTIFANCVALAVYTPFPNSDSNSTNAALEKIEYIFLVIF 106
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
T EC++K++A GF+ HP +YLRN WNILDF IVVIG++ST LS + +GFDVKALRAFRV
Sbjct: 107 TAECIMKLIAYGFILHPGSYLRNGWNILDFTIVVIGMISTALSNLMKEGFDVKALRAFRV 166
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLRLVSGVPSLQVVLN+ILRAM+PLLHIALLVLFVI+IYAIIGLELF GKLH +C
Sbjct: 167 LRPLRLVSGVPSLQVVLNSILRAMVPLLHIALLVLFVIIIYAIIGLELFSGKLHKSCFHN 226
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
TG++ DP PCG D F C + E W GPN GITNFDNFGL
Sbjct: 227 ETGEI-MDDPHPCGED----GFHCDT--------ISPEMVCRYYWEGPNFGITNFDNFGL 273
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKE 1122
+MLTVFQCV+LEGWTD++Y+V DA+G W W+YF+++VILG+FFV+NL+LGVLSGEFSKE
Sbjct: 274 SMLTVFQCVTLEGWTDMLYYV-DAMGSSWQWVYFISMVILGAFFVMNLILGVLSGEFSKE 332
Query: 1123 REKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVAQTXXXXXXXX 1302
R KA+ RG FQK REKQQ+EEDL+GYLDWITQAEDI+P N+ E +
Sbjct: 333 RTKAKNRGDFQKLREKQQIEEDLRGYLDWITQAEDIDPDNDASGMQEGKMKNIIELDSSD 392
Query: 1303 XXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEH 1482
S A + K ++++N VKSQ FYW +EH
Sbjct: 393 NVGEDGEIQHESWVARKRKTIDRINRRLRRACRKAVKSQAFYWLIIILVFLNTGVLATEH 452
Query: 1483 YGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVL 1662
Y Q WLD FQ N+FFV LF+MEMLLKMYSLGF Y S FNRFDCFVVI SI E +L
Sbjct: 453 YRQPPWLDDFQEYTNMFFVALFTMEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSIGEMIL 512
Query: 1663 VYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1842
+M PLGVSVLR RLLR+FKVTKYW
Sbjct: 513 TSTQIMPPLGVSVLRCVRLLRVFKVTKYWQSLSNLVASLLNSIQSIASLLLLLFLFIVIF 572
Query: 1843 XXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGT 2022
GMQVFGGKFNFN KPR+NFD+FVQ+LLTVFQILTGEDWN VMY GI+++GGV +
Sbjct: 573 ALLGMQVFGGKFNFNSSVDKPRSNFDSFVQSLLTVFQILTGEDWNMVMYDGIQAYGGVAS 632
Query: 2023 LGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLT 2139
LG+I IY+I+LFICGNYILLNVFLAIAVDNLADADSLT
Sbjct: 633 LGIIASIYFIILFICGNYILLNVFLAIAVDNLADADSLT 671
Score = 121 bits (304), Expect = 2e-25
Identities = 88/313 (28%), Positives = 150/313 (47%), Gaps = 10/313 (3%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
N R C + F +IL I + LA P A +N +L +Y F VF
Sbjct: 787 NRFRIFCHWLCNHSTFGNIILVCIMFSSAMLAAEDPLNANSE--RNQILNYFDYFFTSVF 844
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
TIE +LK+V+ GF+FH A+ R+A+N+LD ++V + L+S S +I +K LR RV
Sbjct: 845 TIELLLKLVSYGFLFHDGAFCRSAFNLLDLLVVCVSLISMFFSSGAIS--VIKILRVLRV 902
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLR ++ L+ V+ ++ A+ + +I L+ + ++A+IG++L+ GK S
Sbjct: 903 LRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLYKGKFFS----- 957
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMG-VRWECSSNTTWPGPNNGITNFDNFG 939
C ++ +C + + G V S W + +FD+
Sbjct: 958 ------------CSDGSKMQESECHGTYLVYEDGNVDKPVSKERYW---SRNRFHFDDVS 1002
Query: 940 LAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWI---------YFVTLVILGSFFVLNLVL 1092
AMLT+F + EGW ++Y D+ + I Y++ +I+ +FF++N+ +
Sbjct: 1003 KAMLTLFTVSTFEGWPGLLYVSIDSHEEDSGPIHNFRPIVAAYYIIYIIIIAFFMVNIFV 1062
Query: 1093 GVLSGEFSKEREK 1131
G + F E E+
Sbjct: 1063 GFVIVTFQNEGEQ 1075
Score = 110 bits (276), Expect = 3e-22
Identities = 71/256 (27%), Positives = 131/256 (50%), Gaps = 2/256 (0%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S+AF ++I +++ +NT LA +HY +DF + N+ F +F E +LK+ +L
Sbjct: 428 VKSQAFYWLIIILVFLNTGVLATEHYRQPPWLDDFQEYTNMFFVALFTMEMLLKMYSLGF 487
Query: 3520 KNYISDRWNVFDLLVVVGSF--IDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ Y +N FD VV+GS + +T ++ P + ++ R R++R+ K+ +
Sbjct: 488 QGYFVSLFNRFDCFVVIGSIGEMILTSTQIMPP----LGVSVLRCVRLLRVFKVTKYWQS 543
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAA 3873
+ L+ + + S Q++ + LL+ L I+A++GMQ FG +S+ +NF SF +
Sbjct: 544 LSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNFNSSVDKPRSNFDSFVQS 603
Query: 3874 ILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFML 4053
+L +F+ TGE W +M GG+ A YFI F+
Sbjct: 604 LLTVFQILTGEDWNMVMYDGIQA-------------YGGVASL---GIIASIYFIILFIC 647
Query: 4054 CSFLVINLFVAVIMDN 4101
+++++N+F+A+ +DN
Sbjct: 648 GNYILLNVFLAIAVDN 663
Score = 102 bits (254), Expect = 1e-19
Identities = 80/272 (29%), Positives = 123/272 (44%), Gaps = 20/272 (7%)
Frame = +1
Query: 2305 VKPIPKAS--SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPL---QA 2469
VKP P +LF L+ TN R C +V F +L I + LA P +
Sbjct: 29 VKPQPDRPMRALFCLTRTNPLRKLCIAIVEWKPFEYLILLTIFANCVALAVYTPFPNSDS 88
Query: 2470 NSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFV 2649
NST N L +Y F +FT E +K+I +G + H GS+ RN +N+LD +V + + S
Sbjct: 89 NST-NAALEKIEYIFLVIFTAECIMKLIAYGFILHPGSYLRNGWNILDFTIVVIGMISTA 147
Query: 2650 LRTDAMSXXXXXXXXXXXXXXXAINRAKG---LKHVVQCVIVAVKTIGNIMLVTFMLQFM 2820
L ++ M + G L+ V+ ++ A+ + +I L+ + +
Sbjct: 148 L-SNLMKEGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSILRAMVPLLHIALLVLFVIII 206
Query: 2821 FAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIH-----YEDGDPTKPVSKKRV----WSN 2973
+AIIG++LF G L K GE + EDG +S + V W
Sbjct: 207 YAIIGLELFSG------KLHKSCFHNETGEIMDDPHPCGEDGFHCDTISPEMVCRYYWEG 260
Query: 2974 NDF---NFDNVGDAMISLFVVSTFEGWPQLLY 3060
+F NFDN G +M+++F T EGW +LY
Sbjct: 261 PNFGITNFDNFGLSMLTVFQCVTLEGWTDMLY 292
Score = 91.7 bits (226), Expect = 2e-16
Identities = 81/357 (22%), Positives = 149/357 (41%), Gaps = 32/357 (8%)
Frame = +1
Query: 262 KPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGF 441
+PFE++I +I N I L++ + Q Y +L+ + +F VF +E V K+ A F
Sbjct: 1119 QPFEYMIFVLIMINTITLSM--KFYRQPEIYTE-VLDLLNLIFTAVFALEFVFKLAAFRF 1175
Query: 442 MFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--------FDVKALRAFRVLRPLR 597
Y +AWN+ DFIIV+ + + S+++I + R FRV+R ++
Sbjct: 1176 ----KNYFGDAWNVFDFIIVLGSFIDIVYSEVNISKGMKGGSSIISINFFRLFRVMRLVK 1231
Query: 598 LVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQL 777
L++ ++ +L +++ L ++ALL++ + IYA+IG+++F G++
Sbjct: 1232 LLARGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-------------GKI 1278
Query: 778 AQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTV 957
A D T + NF F A+L +
Sbjct: 1279 AMDDETSIHRN------------------------------------NNFQTFPQAVLVL 1302
Query: 958 FQCVSLEGWTDVMYWVN------------------DAVGREWPWIYFVTLVILGSFFVLN 1083
F+ + E W D+M + + G + YF++ +L SF ++N
Sbjct: 1303 FRSATGEAWQDIMLDCSSRPGEVNCDAKSDDAGSPEGCGSNIAFPYFISFYVLCSFLIIN 1362
Query: 1084 LVLGVLSGEF---SKEREKARARGLFQKFREKQQLEEDLKG---YLDWITQAEDIEP 1236
L + V+ F +++ L + R + + D KG +LD +T I P
Sbjct: 1363 LFVAVIMDNFDYLTRDWSILGPHHLDEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 1419
Score = 90.5 bits (223), Expect = 4e-16
Identities = 74/295 (25%), Positives = 132/295 (44%), Gaps = 43/295 (14%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLAC-KHYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FEY+I L I N V+LA +P+S L+ IF +F E ++K++A
Sbjct: 60 KPFEYLILLTIFANCVALAVYTPFPNSDSNSTNAALEKIEYIFLVIFTAECIMKLIAYGF 119
Query: 3511 -LNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRG 3687
L+P +Y+ + WN+ D +VV I L G + R FRV+R ++L+S
Sbjct: 120 ILHPGSYLRNGWNILDFTIVVIGMISTALSNLMKEG---FDVKALRAFRVLRPLRLVSGV 176
Query: 3688 EGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKV-----------ALDDST 3831
++ +L + +++ L ++ALL++ + IYA+IG++ F GK+ +DD
Sbjct: 177 PSLQVVLNSILRAMVPLLHIALLVLFVIIIYAIIGLELFSGKLHKSCFHNETGEIMDDPH 236
Query: 3832 SIHRN------------------------NNFHSFPAAILVLFRSATGEAWQDIMLSCSD 3939
+ NF +F ++L +F+ T E W D++
Sbjct: 237 PCGEDGFHCDTISPEMVCRYYWEGPNFGITNFDNFGLSMLTVFQCVTLEGWTDML----- 291
Query: 3940 REDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
Y+ + G+++ + YFIS +L +F V+NL + V+ F
Sbjct: 292 ------------YYVDAM-----GSSWQWVYFISMVILGAFFVMNLILGVLSGEF 329
Score = 69.7 bits (169), Expect = 8e-10
Identities = 56/256 (21%), Positives = 97/256 (37%), Gaps = 20/256 (7%)
Frame = +1
Query: 1408 VKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGF 1587
V SQ F + + + Y Q E + NL F +F++E + K+ + F
Sbjct: 1116 VTSQPFEYMIFVLIMINTITLSMKFYRQPEIYTEVLDLLNLIFTAVFALEFVFKLAAFRF 1175
Query: 1588 TTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPL-------GVSVLRSARLLRIFKVTKY 1746
Y +N FD +V+ S ++ V ++ K + ++ R R++R+ K+
Sbjct: 1176 KNYFGDAWNVFDFIIVLGSFIDIVYSEVNISKGMKGGSSIISINFFRLFRVMRLVKLLAR 1235
Query: 1747 WTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTF 1926
GMQVFG + NF TF
Sbjct: 1236 GEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAMDDETSIHRNNNFQTF 1295
Query: 1927 VQALLTVFQILTGEDWNTVMYHGIESFGGV-------------GTLGVIVCIYYIVLFIC 2067
QA+L +F+ TGE W +M G V G I Y+I ++
Sbjct: 1296 PQAVLVLFRSATGEAWQDIMLDCSSRPGEVNCDAKSDDAGSPEGCGSNIAFPYFISFYVL 1355
Query: 2068 GNYILLNVFLAIAVDN 2115
+++++N+F+A+ +DN
Sbjct: 1356 CSFLIINLFVAVIMDN 1371
Score = 54.3 bits (129), Expect = 3e-05
Identities = 52/231 (22%), Positives = 88/231 (37%), Gaps = 38/231 (16%)
Frame = +1
Query: 1531 FFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVS 1698
FF +F++E+LLK+ S GF + S FN D VV S++ ++F +
Sbjct: 839 FFTSVFTIELLLKLVSYGFLFHDGAFCRSAFNLLDLLVVCVSLIS---MFFSSGAISVIK 895
Query: 1699 VLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF 1878
+LR R+LR + G+Q++ GKF
Sbjct: 896 ILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLYKGKF 955
Query: 1879 ----------------------NFNPQQP--------KPRANFDTFVQALLTVFQILTGE 1968
+ N +P + R +FD +A+LT+F + T E
Sbjct: 956 FSCSDGSKMQESECHGTYLVYEDGNVDKPVSKERYWSRNRFHFDDVSKAMLTLFTVSTFE 1015
Query: 1969 DWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
W ++Y I+S G + IV YYI+ I + ++N+F+ +
Sbjct: 1016 GWPGLLYVSIDSHEEDSGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVI 1066
Score = 53.1 bits (126), Expect = 7e-05
Identities = 48/238 (20%), Positives = 98/238 (41%), Gaps = 3/238 (1%)
Frame = +1
Query: 2371 CNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKV 2550
C V F ++ + +++ +LA E Q + Y + FF ++FT+E+ LK+
Sbjct: 424 CRKAVKSQAFYWLIIILVFLNTGVLATEHYRQPPWLDDF-QEYTNMFFVALFTMEMLLKM 482
Query: 2551 IVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRA 2730
G +G F + FN D VV S+ +L + +
Sbjct: 483 YSLGF---QGYFV-SLFNRFDCFVVIGSIGEMILTSTQIMPPLGVSVLRCVRLLRVFKVT 538
Query: 2731 K---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAEC 2901
K L ++V ++ ++++I +++L+ F+ +FA++G+Q+F G F + + K
Sbjct: 539 KYWQSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNFNSSVDKPRS--- 595
Query: 2902 RGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
NFD+ +++++F + T E W ++Y I +
Sbjct: 596 ---------------------------NFDSFVQSLLTVFQILTGEDWNMVMYDGIQA 626
>gi|29378315|gb|AAO83839.1| voltage-dependent L-type calcium channel
alpha-1 subunit isoform b [Lymnaea stagnalis]
Length = 2186
Score = 1145 bits (2963), Expect = 0.0
Identities = 585/926 (63%), Positives = 700/926 (75%), Gaps = 7/926 (0%)
Frame = +1
Query: 2257 TSARPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSS 2436
+SARPRRMSE+ +S VKPIP SSLFI S TN FR+ C+ + NHSYF N VL CIL+SS
Sbjct: 908 SSARPRRMSELHISSRVKPIPPFSSLFIFSATNKFRIICHKICNHSYFGNVVLACILISS 967
Query: 2437 AMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDI 2616
AMLAAEDPL+ S RN ILN FDYFFTSVFT+EI +K+I +GL+ HKGSFCR+ F++LD+
Sbjct: 968 AMLAAEDPLRNESPRNQILNKFDYFFTSVFTIEIIIKIITYGLMLHKGSFCRSLFSILDL 1027
Query: 2617 LVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIML 2796
+VVAVSL SF L A+S AINRAKGLKHVVQCVIVA++TI NIML
Sbjct: 1028 VVVAVSLISFPLDNQAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVALRTIYNIML 1087
Query: 2797 VTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNN 2976
VTF+L FMF+++GVQLFKG F +C D SK+TE EC+G +I Y+DG P ++R W N
Sbjct: 1088 VTFLLNFMFSVMGVQLFKGKFSMCTDESKLTEDECQGNFITYDDGKFNSPNIEERKWKKN 1147
Query: 2977 DFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXX 3156
DFNFD+V + M++LF VSTFEGWP LLY +IDS+ E KGPI NS+ AVA+
Sbjct: 1148 DFNFDDVSNGMLTLFTVSTFEGWPGLLYKSIDSHAEGKGPIQNSKPAVAVFYFIFIIVIA 1207
Query: 3157 XXXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWW 3336
GFVIVTFQNEGE+EY+NCELDKNQRKCIEFALK KP RRYIP+ R QY++WW
Sbjct: 1208 FFMMNIFVGFVIVTFQNEGEQEYKNCELDKNQRKCIEFALKVKPIRRYIPKARWQYKIWW 1267
Query: 3337 FVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALN 3516
FVTS+AFEY IF++I++NTV+LA K++ S + D LD N+IFTGVF E VLK+ A
Sbjct: 1268 FVTSQAFEYGIFVLIMINTVALAMKYHGQSASYSDALDYLNIIFTGVFTVEFVLKLAAFR 1327
Query: 3517 PKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGI 3696
KNY D WNVFD ++V+GSFIDI Y ++NPG ISINFFRLFRVMRL+KLLSRGEGI
Sbjct: 1328 FKNYFGDAWNVFDFIIVLGSFIDIIYAEVNPGKA-FISINFFRLFRVMRLIKLLSRGEGI 1386
Query: 3697 RTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAI 3876
RTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FG++ LD +T IH NNNF +FP A+
Sbjct: 1387 RTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGRIKLDYNTQIHPNNNFQTFPHAV 1446
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLN-----ESRCGNNFAYPYFIS 4041
LVLFRSATGE+WQ+IML+CSD+ V+CDP ++ G+N +RCGN+FAY YFIS
Sbjct: 1447 LVLFRSATGESWQEIMLACSDKTAVKCDPAVIEH---GVNVTDAEANRCGNDFAYVYFIS 1503
Query: 4042 FFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVV 4221
F++LCSFL+INLFVAVIMDNFDYLTRDWSILGPHHL+EFVRLWSEYDP+AKGRIKHLDVV
Sbjct: 1504 FYILCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFVRLWSEYDPEAKGRIKHLDVV 1563
Query: 4222 TLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNI 4401
TLLRKISPPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFALVRT+LKI TEGNI
Sbjct: 1564 TLLRKISPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTSLKIKTEGNI 1623
Query: 4402 DEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEM 4581
D ANE+LR+ IK+IWKRT LLD+VVPPAG++DDVTVGKFYATFLIQDYFRRFKKRKE
Sbjct: 1624 DTANEELRTVIKKIWKRTSPKLLDQVVPPAGRDDDVTVGKFYATFLIQDYFRRFKKRKEQ 1683
Query: 4582 EAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDE--PEPQHRRPHSLF 4755
K + ALQAGLR +H++GPE++RAISGNL+ + D+ EP HRR HSLF
Sbjct: 1684 MVK--ISKGQEHTNALQAGLRAVHDLGPEIRRAISGNLDEEEMMDKEVEEPMHRRNHSLF 1741
Query: 4756 NNLVHRLSGAGSKSPTEHERIEKGSTLLPFQPRSFSPTHSLAGAEGSPVPSQMHRGAPIN 4935
++V ++G +LPF R T SL G +G + A
Sbjct: 1742 GSVVSAMAGV--------------RPILPFLNR----TQSLKGTKGHNTSNLSPIIAVST 1783
Query: 4936 QSINLPPVNGSARRLPALPPYANHIH 5013
+ + +NG+ P+ NH++
Sbjct: 1784 AATKMIGMNGNIGNAPS----CNHLN 1805
Score = 727 bits (1876), Expect = 0.0
Identities = 377/643 (58%), Positives = 450/643 (69%), Gaps = 4/643 (0%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIRK CI + E+K FEFL+L I ANC+ALAIY PYP DS+ N+ L+ IEYVF+V+F
Sbjct: 134 NPIRKFCIQVAEYKAFEFLVLITIFANCVALAIYTPYPMSDSNEVNSALDRIEYVFLVIF 193
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
+E +LKI+A GF+ H AYLRN WN LDF IVVIG++S+ILS + +GFDVKALRAFRV
Sbjct: 194 LLEGILKIIAYGFVMHQGAYLRNGWNALDFTIVVIGIISSILSFVQEKGFDVKALRAFRV 253
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLRLVS PSLQVVLN+I+RAM+PLLHIALLV+FVI+IYAIIGLELF GKLH+ C
Sbjct: 254 LRPLRLVSRAPSLQVVLNSIVRAMVPLLHIALLVIFVIIIYAIIGLELFYGKLHNACYKI 313
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
+ + + DP C G + C D + + G + EC W GPN GITNFDNFGL
Sbjct: 314 NSTEFS-GDPRIC-----GQGYSC---DDIASGGEKGECREG--WEGPNYGITNFDNFGL 362
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKE 1122
AMLTVFQC+++EGWT V+Y VN+A+G EWPWIYF++L+I+GSFFVLNLVLGVLSGEFSKE
Sbjct: 363 AMLTVFQCITMEGWTTVLYDVNNALGNEWPWIYFISLIIIGSFFVLNLVLGVLSGEFSKE 422
Query: 1123 REKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPV---AQTXXXXX 1293
REKA+ARG FQK REKQQLEEDL+GYLDWITQAEDI+P EDE E+ ++
Sbjct: 423 REKAKARGDFQKLREKQQLEEDLRGYLDWITQAEDIDPEVEDENEEGATPRHSKITSDID 482
Query: 1294 XXXXXXXXXXXXXPSKWAARMK-RLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXX 1470
W + + L+KLN +VKSQ FYW
Sbjct: 483 SEDKVEEGENVEIQQSWLQQKRLHLQKLNRRYRRFCRRIVKSQAFYWGVIVLVFLNTVVL 542
Query: 1471 TSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSIL 1650
TSEHY Q WLD FQ +ANLFFV+LF+MEML+KMYSLGF Y S FNRFD FVV+ SIL
Sbjct: 543 TSEHYKQPVWLDDFQAIANLFFVVLFTMEMLVKMYSLGFQGYFVSLFNRFDSFVVVCSIL 602
Query: 1651 EFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXX 1830
E +L Y ++ PLG+SVLR ARLLR+FK T+YW+
Sbjct: 603 EVILQYTNVFPPLGISVLRCARLLRVFKATRYWSSLRNLVASLLNSMRSIASLLLLLFLF 662
Query: 1831 XXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFG 2010
GMQ+FGGKFNF PQ KPR+NFDTF +LLTVFQILTGEDWN VMY GI ++
Sbjct: 663 IVIFALLGMQLFGGKFNF-PQGEKPRSNFDTFWPSLLTVFQILTGEDWNAVMYDGIRAYD 721
Query: 2011 GVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLT 2139
GV G++VC+Y++VLFI GNYILLNVFLAIAVDNLADA SLT
Sbjct: 722 GVKFPGILVCLYFVVLFIVGNYILLNVFLAIAVDNLADAQSLT 764
Score = 113 bits (282), Expect = 6e-23
Identities = 83/313 (26%), Positives = 153/313 (48%), Gaps = 10/313 (3%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
N R +C I F ++L I + LA P ++ +N +L +Y F VF
Sbjct: 940 NKFRIICHKICNHSYFGNVVLACILISSAMLAAEDPL--RNESPRNQILNKFDYFFTSVF 997
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
TIE ++KI+ G M H ++ R+ ++ILD ++V + L+S L +I VK LR RV
Sbjct: 998 TIEIIIKIITYGLMLHKGSFCRSLFSILDLVVVAVSLISFPLDNQAIS--VVKILRVLRV 1055
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLR ++ L+ V+ ++ A+ + +I L+ + +++++G++LF GK S C D
Sbjct: 1056 LRPLRAINRAKGLKHVVQCVIVALRTIYNIMLVTFLLNFMFSVMGVQLFKGKF-SMCTD- 1113
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
+++ + +CQ + +T ++ + N NFD+
Sbjct: 1114 ---------------ESKLTEDECQ-GNFITYDDGKFNSPNIEERKWKKNDF-NFDDVSN 1156
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDA-------VGREWPWI---YFVTLVILGSFFVLNLVL 1092
MLT+F + EGW ++Y D+ + P + YF+ ++++ +FF++N+ +
Sbjct: 1157 GMLTLFTVSTFEGWPGLLYKSIDSHAEGKGPIQNSKPAVAVFYFIFIIVI-AFFMMNIFV 1215
Query: 1093 GVLSGEFSKEREK 1131
G + F E E+
Sbjct: 1216 GFVIVTFQNEGEQ 1228
Score = 104 bits (259), Expect = 3e-20
Identities = 77/298 (25%), Positives = 146/298 (48%), Gaps = 4/298 (1%)
Frame = +1
Query: 3220 EYENCELDKN--QRKCIEFALKAKPHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNT 3393
E EN E+ ++ Q+K + + +RR+ R V S+AF + + +++ +NT
Sbjct: 489 EGENVEIQQSWLQQKRLHLQKLNRRYRRFCRR---------IVKSQAFYWGVIVLVFLNT 539
Query: 3394 VSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVG 3573
V L +HY +DF + NL F +F E ++K+ +L + Y +N FD VVV
Sbjct: 540 VVLTSEHYKQPVWLDDFQAIANLFFVVLFTMEMLVKMYSLGFQGYFVSLFNRFDSFVVVC 599
Query: 3574 SFIDI--TYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYV 3747
S +++ Y + P + I+ R R++R+ K +R L+ + + S +++ +
Sbjct: 600 SILEVILQYTNVFPP----LGISVLRCARLLRVFKATRYWSSLRNLVASLLNSMRSIASL 655
Query: 3748 ALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIML 3927
LL+ L I+A++GMQ FG + +NF +F ++L +F+ TGE W +M
Sbjct: 656 LLLLFLFIVIFALLGMQLFGG-KFNFPQGEKPRSNFDTFWPSLLTVFQILTGEDWNAVMY 714
Query: 3928 SCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDN 4101
+ +R D G+ YF+ F++ +++++N+F+A+ +DN
Sbjct: 715 -----DGIRA---YDGVKFPGI--------LVCLYFVVLFIVGNYILLNVFLAIAVDN 756
Score = 100 bits (249), Expect = 4e-19
Identities = 72/260 (27%), Positives = 119/260 (45%), Gaps = 14/260 (5%)
Frame = +1
Query: 2323 ASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR--NMILN 2496
A +LF L+ N R FC V + F VL I + LA P + + N L+
Sbjct: 124 ARALFCLTLKNPIRKFCIQVAEYKAFEFLVLITIFANCVALAIYTPYPMSDSNEVNSALD 183
Query: 2497 YFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLR--TDAMS 2670
+Y F +F +E LK+I +G V H+G++ RN +N LD +V + + S +L +
Sbjct: 184 RIEYVFLVIFLLEGILKIIAYGFVMHQGAYLRNGWNALDFTIVVIGIISSILSFVQEKGF 243
Query: 2671 XXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFK 2850
++RA L+ V+ ++ A+ + +I L+ + ++AIIG++LF
Sbjct: 244 DVKALRAFRVLRPLRLVSRAPSLQVVLNSIVRAMVPLLHIALLVIFVIIIYAIIGLELFY 303
Query: 2851 GTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSK-------KRVWSNNDF---NFDNVG 3000
G L N K+ E G+ G ++ + W ++ NFDN G
Sbjct: 304 GK--LHNACYKINSTEFSGDPRICGQGYSCDDIASGGEKGECREGWEGPNYGITNFDNFG 361
Query: 3001 DAMISLFVVSTFEGWPQLLY 3060
AM+++F T EGW +LY
Sbjct: 362 LAMLTVFQCITMEGWTTVLY 381
Score = 93.6 bits (231), Expect = 5e-17
Identities = 84/344 (24%), Positives = 146/344 (42%), Gaps = 45/344 (13%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLAC-KHYPSSRGFE--DFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+AFE+++ + I N V+LA YP S E LD +F +F E +LKI+A
Sbjct: 147 KAFEFLVLITIFANCVALAIYTPYPMSDSNEVNSALDRIEYVFLVIFLLEGILKIIAYGF 206
Query: 3511 -LNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRG 3687
++ Y+ + WN D +VV I + G + R FRV+R ++L+SR
Sbjct: 207 VMHQGAYLRNGWNALDFTIVVIGIISSILSFVQEKG---FDVKALRAFRVLRPLRLVSRA 263
Query: 3688 EGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV----------------- 3813
++ +L + +++ L ++ALL++ + IYA+IG++ F+GK+
Sbjct: 264 PSLQVVLNSIVRAMVPLLHIALLVIFVIIIYAIIGLELFYGKLHNACYKINSTEFSGDPR 323
Query: 3814 ------ALDDSTS--------------IHRNNNFHSFPAAILVLFRSATGEAWQDIMLSC 3933
+ DD S + NF +F A+L +F+ T E W ++
Sbjct: 324 ICGQGYSCDDIASGGEKGECREGWEGPNYGITNFDNFGLAMLTVFQCITMEGWTTVLYDV 383
Query: 3934 SDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYL 4113
+ + GN + + YFIS ++ SF V+NL + V+ F
Sbjct: 384 N---------------------NALGNEWPWIYFISLIIIGSFFVLNLVLGVLSGEFSKE 422
Query: 4114 TRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
G + +R + + D +G +LD +T I P
Sbjct: 423 REKAKARGDF---QKLREKQQLEEDLRG---YLDWITQAEDIDP 460
Score = 90.5 bits (223), Expect = 4e-16
Identities = 86/351 (24%), Positives = 154/351 (43%), Gaps = 28/351 (7%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+ I +I N +ALA+ Y Q + Y + L + + +F VFT+E VLK+ A F
Sbjct: 1274 FEYGIFVLIMINTVALAM--KYHGQSASYSDAL-DYLNIIFTGVFTVEFVLKLAAFRF-- 1328
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKALRAFRVLRPLRLVSGVPSL 621
Y +AWN+ DFIIV+ + I ++++ + R FRV+R ++L+S +
Sbjct: 1329 --KNYFGDAWNVFDFIIVLGSFIDIIYAEVNPGKAFISINFFRLFRVMRLIKLLSRGEGI 1386
Query: 622 QVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKL---HSTCIDP---------- 762
+ +L +++ L ++ALL++ + IYA+IG+++F G++ ++T I P
Sbjct: 1387 RTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMF-GRIKLDYNTQIHPNNNFQTFPHA 1445
Query: 763 -------ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGIT 921
ATG+ Q+ C T A KC P+
Sbjct: 1446 VLVLFRSATGESWQEIMLACSDKT---AVKCDPA-------------------------- 1476
Query: 922 NFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVL 1101
+E +V + G ++ ++YF++ IL SF ++NL + V+
Sbjct: 1477 ----------------VIEHGVNVTDAEANRCGNDFAYVYFISFYILCSFLIINLFVAVI 1520
Query: 1102 SGEF---SKEREKARARGLFQKFREKQQLEEDLKG---YLDWITQAEDIEP 1236
F +++ L + R + + + KG +LD +T I P
Sbjct: 1521 MDNFDYLTRDWSILGPHHLDEFVRLWSEYDPEAKGRIKHLDVVTLLRKISP 1571
Score = 72.8 bits (177), Expect = 9e-11
Identities = 56/256 (21%), Positives = 101/256 (38%), Gaps = 20/256 (7%)
Frame = +1
Query: 1408 VKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGF 1587
V SQ F + +++GQS N+ F +F++E +LK+ + F
Sbjct: 1269 VTSQAFEYGIFVLIMINTVALAMKYHGQSASYSDALDYLNIIFTGVFTVEFVLKLAAFRF 1328
Query: 1588 TTYTTSQFNRFDCFVVISSILEFVLVYFDLMKP-LGVSVLRSARLLRIFKVTKYWTXXXX 1764
Y +N FD +V+ S ++ + + K + ++ R R++R+ K+
Sbjct: 1329 KNYFGDAWNVFDFIIVLGSFIDIIYAEVNPGKAFISINFFRLFRVMRLIKLLSRGEGIRT 1388
Query: 1765 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGG-KFNFNPQQPKPRANFDTFVQALL 1941
GMQ+FG K ++N Q P NF TF A+L
Sbjct: 1389 LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGRIKLDYNTQI-HPNNNFQTFPHAVL 1447
Query: 1942 TVFQILTGEDWNTVMY----------------HGIESFGGVGTL--GVIVCIYYIVLFIC 2067
+F+ TGE W +M HG+ +Y+I +I
Sbjct: 1448 VLFRSATGESWQEIMLACSDKTAVKCDPAVIEHGVNVTDAEANRCGNDFAYVYFISFYIL 1507
Query: 2068 GNYILLNVFLAIAVDN 2115
+++++N+F+A+ +DN
Sbjct: 1508 CSFLIINLFVAVIMDN 1523
Score = 54.7 bits (130), Expect = 3e-05
Identities = 53/252 (21%), Positives = 110/252 (43%), Gaps = 6/252 (2%)
Frame = +1
Query: 2359 FRVFCNMVVNHSYFTNAVLFCILVSSAMLAAE---DPLQANSTRNMILNYFDYFFTSVFT 2529
+R FC +V F V+ + +++ +L +E P+ + + + + FF +FT
Sbjct: 514 YRRFCRRIVKSQAFYWGVIVLVFLNTVVLTSEHYKQPVWLDDFQAIA----NLFFVVLFT 569
Query: 2530 VEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXX 2709
+E+ +K+ G +G F + FN D VV S+ +L+ +
Sbjct: 570 MEMLVKMYSLGF---QGYFV-SLFNRFDSFVVVCSILEVILQYTNVFPPLGISVLRCARL 625
Query: 2710 XXAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLS 2880
+ L+++V ++ ++++I +++L+ F+ +FA++G+QLF G F
Sbjct: 626 LRVFKATRYWSSLRNLVASLLNSMRSIASLLLLLFLFIVIFALLGMQLFGGKF------- 678
Query: 2881 KMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLY 3060
++ G+ KP S NFD +++++F + T E W ++Y
Sbjct: 679 ------------NFPQGE--KPRS----------NFDTFWPSLLTVFQILTGEDWNAVMY 714
Query: 3061 VAIDSNEEDKGP 3096
I + + K P
Sbjct: 715 DGIRAYDGVKFP 726
Score = 47.0 bits (110), Expect = 0.005
Identities = 48/231 (20%), Positives = 84/231 (35%), Gaps = 38/231 (16%)
Frame = +1
Query: 1531 FFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVS 1698
FF +F++E+++K+ + G ++ S F+ D VV S++ F L D V
Sbjct: 992 FFTSVFTIEIIIKIITYGLMLHKGSFCRSLFSILDLVVVAVSLISFPL---DNQAISVVK 1048
Query: 1699 VLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF 1878
+LR R+LR + G+Q+F GKF
Sbjct: 1049 ILRVLRVLRPLRAINRAKGLKHVVQCVIVALRTIYNIMLVTFLLNFMFSVMGVQLFKGKF 1108
Query: 1879 N------------------------FNPQQPKPRA------NFDTFVQALLTVFQILTGE 1968
+ FN + R NFD +LT+F + T E
Sbjct: 1109 SMCTDESKLTEDECQGNFITYDDGKFNSPNIEERKWKKNDFNFDDVSNGMLTLFTVSTFE 1168
Query: 1969 DWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
W ++Y I+S G + V ++Y + I + ++N+F+ +
Sbjct: 1169 GWPGLLYKSIDSHAEGKGPIQNSKPAVAVFYFIFIIVIAFFMMNIFVGFVI 1219
>gi|29378313|gb|AAO83838.1| voltage-dependent L-type calcium channel
alpha-1 subunit isoform a [Lymnaea stagnalis]
Length = 2190
Score = 1145 bits (2963), Expect = 0.0
Identities = 585/926 (63%), Positives = 700/926 (75%), Gaps = 7/926 (0%)
Frame = +1
Query: 2257 TSARPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSS 2436
+SARPRRMSE+ +S VKPIP SSLFI S TN FR+ C+ + NHSYF N VL CIL+SS
Sbjct: 908 SSARPRRMSELHISSRVKPIPPFSSLFIFSATNKFRIICHKICNHSYFGNVVLACILISS 967
Query: 2437 AMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDI 2616
AMLAAEDPL+ S RN ILN FDYFFTSVFT+EI +K+I +GL+ HKGSFCR+ F++LD+
Sbjct: 968 AMLAAEDPLRNESPRNQILNKFDYFFTSVFTIEIIIKIITYGLMLHKGSFCRSLFSILDL 1027
Query: 2617 LVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIML 2796
+VVAVSL SF L A+S AINRAKGLKHVVQCVIVA++TI NIML
Sbjct: 1028 VVVAVSLISFPLDNQAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVALRTIYNIML 1087
Query: 2797 VTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNN 2976
VTF+L FMF+++GVQLFKG F +C D SK+TE EC+G +I Y+DG P ++R W N
Sbjct: 1088 VTFLLNFMFSVMGVQLFKGKFSMCTDESKLTEDECQGNFITYDDGKFNSPNIEERKWKKN 1147
Query: 2977 DFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXX 3156
DFNFD+V + M++LF VSTFEGWP LLY +IDS+ E KGPI NS+ AVA+
Sbjct: 1148 DFNFDDVSNGMLTLFTVSTFEGWPGLLYKSIDSHAEGKGPIQNSKPAVAVFYFIFIIVIA 1207
Query: 3157 XXXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWW 3336
GFVIVTFQNEGE+EY+NCELDKNQRKCIEFALK KP RRYIP+ R QY++WW
Sbjct: 1208 FFMMNIFVGFVIVTFQNEGEQEYKNCELDKNQRKCIEFALKVKPIRRYIPKARWQYKIWW 1267
Query: 3337 FVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALN 3516
FVTS+AFEY IF++I++NTV+LA K++ S + D LD N+IFTGVF E VLK+ A
Sbjct: 1268 FVTSQAFEYGIFVLIMINTVALAMKYHGQSASYSDALDYLNIIFTGVFTVEFVLKLAAFR 1327
Query: 3517 PKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGI 3696
KNY D WNVFD ++V+GSFIDI Y ++NPG ISINFFRLFRVMRL+KLLSRGEGI
Sbjct: 1328 FKNYFGDAWNVFDFIIVLGSFIDIIYAEVNPGKA-FISINFFRLFRVMRLIKLLSRGEGI 1386
Query: 3697 RTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAI 3876
RTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FG++ LD +T IH NNNF +FP A+
Sbjct: 1387 RTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGRIKLDYNTQIHPNNNFQTFPHAV 1446
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLN-----ESRCGNNFAYPYFIS 4041
LVLFRSATGE+WQ+IML+CSD+ V+CDP ++ G+N +RCGN+FAY YFIS
Sbjct: 1447 LVLFRSATGESWQEIMLACSDKTAVKCDPAVIEH---GVNVTDAEANRCGNDFAYVYFIS 1503
Query: 4042 FFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVV 4221
F++LCSFL+INLFVAVIMDNFDYLTRDWSILGPHHL+EFVRLWSEYDP+AKGRIKHLDVV
Sbjct: 1504 FYILCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFVRLWSEYDPEAKGRIKHLDVV 1563
Query: 4222 TLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNI 4401
TLLRKISPPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFALVRT+LKI TEGNI
Sbjct: 1564 TLLRKISPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTSLKIKTEGNI 1623
Query: 4402 DEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEM 4581
D ANE+LR+ IK+IWKRT LLD+VVPPAG++DDVTVGKFYATFLIQDYFRRFKKRKE
Sbjct: 1624 DTANEELRTVIKKIWKRTSPKLLDQVVPPAGRDDDVTVGKFYATFLIQDYFRRFKKRKEQ 1683
Query: 4582 EAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDE--PEPQHRRPHSLF 4755
K + ALQAGLR +H++GPE++RAISGNL+ + D+ EP HRR HSLF
Sbjct: 1684 MVK--ISKGQEHTNALQAGLRAVHDLGPEIRRAISGNLDEEEMMDKEVEEPMHRRNHSLF 1741
Query: 4756 NNLVHRLSGAGSKSPTEHERIEKGSTLLPFQPRSFSPTHSLAGAEGSPVPSQMHRGAPIN 4935
++V ++G +LPF R T SL G +G + A
Sbjct: 1742 GSVVSAMAGV--------------RPILPFLNR----TQSLKGTKGHNTSNLSPIIAVST 1783
Query: 4936 QSINLPPVNGSARRLPALPPYANHIH 5013
+ + +NG+ P+ NH++
Sbjct: 1784 AATKMIGMNGNIGNAPS----CNHLN 1805
Score = 727 bits (1876), Expect = 0.0
Identities = 377/643 (58%), Positives = 450/643 (69%), Gaps = 4/643 (0%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIRK CI + E+K FEFL+L I ANC+ALAIY PYP DS+ N+ L+ IEYVF+V+F
Sbjct: 134 NPIRKFCIQVAEYKAFEFLVLITIFANCVALAIYTPYPMSDSNEVNSALDRIEYVFLVIF 193
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
+E +LKI+A GF+ H AYLRN WN LDF IVVIG++S+ILS + +GFDVKALRAFRV
Sbjct: 194 LLEGILKIIAYGFVMHQGAYLRNGWNALDFTIVVIGIISSILSFVQEKGFDVKALRAFRV 253
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLRLVS PSLQVVLN+I+RAM+PLLHIALLV+FVI+IYAIIGLELF GKLH+ C
Sbjct: 254 LRPLRLVSRAPSLQVVLNSIVRAMVPLLHIALLVIFVIIIYAIIGLELFYGKLHNACYKI 313
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
+ + + DP C G + C D + + G + EC W GPN GITNFDNFGL
Sbjct: 314 NSTEFS-GDPRIC-----GQGYSC---DDIASGGEKGECREG--WEGPNYGITNFDNFGL 362
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKE 1122
AMLTVFQC+++EGWT V+Y VN+A+G EWPWIYF++L+I+GSFFVLNLVLGVLSGEFSKE
Sbjct: 363 AMLTVFQCITMEGWTTVLYDVNNALGNEWPWIYFISLIIIGSFFVLNLVLGVLSGEFSKE 422
Query: 1123 REKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPV---AQTXXXXX 1293
REKA+ARG FQK REKQQLEEDL+GYLDWITQAEDI+P EDE E+ ++
Sbjct: 423 REKAKARGDFQKLREKQQLEEDLRGYLDWITQAEDIDPEVEDENEEGATPRHSKITSDID 482
Query: 1294 XXXXXXXXXXXXXPSKWAARMK-RLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXX 1470
W + + L+KLN +VKSQ FYW
Sbjct: 483 SEDKVEEGENVEIQQSWLQQKRLHLQKLNRRYRRFCRRIVKSQAFYWGVIVLVFLNTVVL 542
Query: 1471 TSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSIL 1650
TSEHY Q WLD FQ +ANLFFV+LF+MEML+KMYSLGF Y S FNRFD FVV+ SIL
Sbjct: 543 TSEHYKQPVWLDDFQAIANLFFVVLFTMEMLVKMYSLGFQGYFVSLFNRFDSFVVVCSIL 602
Query: 1651 EFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXX 1830
E +L Y ++ PLG+SVLR ARLLR+FK T+YW+
Sbjct: 603 EVILQYTNVFPPLGISVLRCARLLRVFKATRYWSSLRNLVASLLNSMRSIASLLLLLFLF 662
Query: 1831 XXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFG 2010
GMQ+FGGKFNF PQ KPR+NFDTF +LLTVFQILTGEDWN VMY GI ++
Sbjct: 663 IVIFALLGMQLFGGKFNF-PQGEKPRSNFDTFWPSLLTVFQILTGEDWNAVMYDGIRAYD 721
Query: 2011 GVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLT 2139
GV G++VC+Y++VLFI GNYILLNVFLAIAVDNLADA SLT
Sbjct: 722 GVKFPGILVCLYFVVLFIVGNYILLNVFLAIAVDNLADAQSLT 764
Score = 113 bits (282), Expect = 6e-23
Identities = 83/313 (26%), Positives = 153/313 (48%), Gaps = 10/313 (3%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
N R +C I F ++L I + LA P ++ +N +L +Y F VF
Sbjct: 940 NKFRIICHKICNHSYFGNVVLACILISSAMLAAEDPL--RNESPRNQILNKFDYFFTSVF 997
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
TIE ++KI+ G M H ++ R+ ++ILD ++V + L+S L +I VK LR RV
Sbjct: 998 TIEIIIKIITYGLMLHKGSFCRSLFSILDLVVVAVSLISFPLDNQAIS--VVKILRVLRV 1055
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLR ++ L+ V+ ++ A+ + +I L+ + +++++G++LF GK S C D
Sbjct: 1056 LRPLRAINRAKGLKHVVQCVIVALRTIYNIMLVTFLLNFMFSVMGVQLFKGKF-SMCTD- 1113
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
+++ + +CQ + +T ++ + N NFD+
Sbjct: 1114 ---------------ESKLTEDECQ-GNFITYDDGKFNSPNIEERKWKKNDF-NFDDVSN 1156
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDA-------VGREWPWI---YFVTLVILGSFFVLNLVL 1092
MLT+F + EGW ++Y D+ + P + YF+ ++++ +FF++N+ +
Sbjct: 1157 GMLTLFTVSTFEGWPGLLYKSIDSHAEGKGPIQNSKPAVAVFYFIFIIVI-AFFMMNIFV 1215
Query: 1093 GVLSGEFSKEREK 1131
G + F E E+
Sbjct: 1216 GFVIVTFQNEGEQ 1228
Score = 104 bits (259), Expect = 3e-20
Identities = 77/298 (25%), Positives = 146/298 (48%), Gaps = 4/298 (1%)
Frame = +1
Query: 3220 EYENCELDKN--QRKCIEFALKAKPHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNT 3393
E EN E+ ++ Q+K + + +RR+ R V S+AF + + +++ +NT
Sbjct: 489 EGENVEIQQSWLQQKRLHLQKLNRRYRRFCRR---------IVKSQAFYWGVIVLVFLNT 539
Query: 3394 VSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVG 3573
V L +HY +DF + NL F +F E ++K+ +L + Y +N FD VVV
Sbjct: 540 VVLTSEHYKQPVWLDDFQAIANLFFVVLFTMEMLVKMYSLGFQGYFVSLFNRFDSFVVVC 599
Query: 3574 SFIDI--TYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYV 3747
S +++ Y + P + I+ R R++R+ K +R L+ + + S +++ +
Sbjct: 600 SILEVILQYTNVFPP----LGISVLRCARLLRVFKATRYWSSLRNLVASLLNSMRSIASL 655
Query: 3748 ALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIML 3927
LL+ L I+A++GMQ FG + +NF +F ++L +F+ TGE W +M
Sbjct: 656 LLLLFLFIVIFALLGMQLFGG-KFNFPQGEKPRSNFDTFWPSLLTVFQILTGEDWNAVMY 714
Query: 3928 SCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDN 4101
+ +R D G+ YF+ F++ +++++N+F+A+ +DN
Sbjct: 715 -----DGIRA---YDGVKFPGI--------LVCLYFVVLFIVGNYILLNVFLAIAVDN 756
Score = 100 bits (249), Expect = 4e-19
Identities = 72/260 (27%), Positives = 119/260 (45%), Gaps = 14/260 (5%)
Frame = +1
Query: 2323 ASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR--NMILN 2496
A +LF L+ N R FC V + F VL I + LA P + + N L+
Sbjct: 124 ARALFCLTLKNPIRKFCIQVAEYKAFEFLVLITIFANCVALAIYTPYPMSDSNEVNSALD 183
Query: 2497 YFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLR--TDAMS 2670
+Y F +F +E LK+I +G V H+G++ RN +N LD +V + + S +L +
Sbjct: 184 RIEYVFLVIFLLEGILKIIAYGFVMHQGAYLRNGWNALDFTIVVIGIISSILSFVQEKGF 243
Query: 2671 XXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFK 2850
++RA L+ V+ ++ A+ + +I L+ + ++AIIG++LF
Sbjct: 244 DVKALRAFRVLRPLRLVSRAPSLQVVLNSIVRAMVPLLHIALLVIFVIIIYAIIGLELFY 303
Query: 2851 GTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSK-------KRVWSNNDF---NFDNVG 3000
G L N K+ E G+ G ++ + W ++ NFDN G
Sbjct: 304 GK--LHNACYKINSTEFSGDPRICGQGYSCDDIASGGEKGECREGWEGPNYGITNFDNFG 361
Query: 3001 DAMISLFVVSTFEGWPQLLY 3060
AM+++F T EGW +LY
Sbjct: 362 LAMLTVFQCITMEGWTTVLY 381
Score = 93.6 bits (231), Expect = 5e-17
Identities = 84/344 (24%), Positives = 146/344 (42%), Gaps = 45/344 (13%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLAC-KHYPSSRGFE--DFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+AFE+++ + I N V+LA YP S E LD +F +F E +LKI+A
Sbjct: 147 KAFEFLVLITIFANCVALAIYTPYPMSDSNEVNSALDRIEYVFLVIFLLEGILKIIAYGF 206
Query: 3511 -LNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRG 3687
++ Y+ + WN D +VV I + G + R FRV+R ++L+SR
Sbjct: 207 VMHQGAYLRNGWNALDFTIVVIGIISSILSFVQEKG---FDVKALRAFRVLRPLRLVSRA 263
Query: 3688 EGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV----------------- 3813
++ +L + +++ L ++ALL++ + IYA+IG++ F+GK+
Sbjct: 264 PSLQVVLNSIVRAMVPLLHIALLVIFVIIIYAIIGLELFYGKLHNACYKINSTEFSGDPR 323
Query: 3814 ------ALDDSTS--------------IHRNNNFHSFPAAILVLFRSATGEAWQDIMLSC 3933
+ DD S + NF +F A+L +F+ T E W ++
Sbjct: 324 ICGQGYSCDDIASGGEKGECREGWEGPNYGITNFDNFGLAMLTVFQCITMEGWTTVLYDV 383
Query: 3934 SDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYL 4113
+ + GN + + YFIS ++ SF V+NL + V+ F
Sbjct: 384 N---------------------NALGNEWPWIYFISLIIIGSFFVLNLVLGVLSGEFSKE 422
Query: 4114 TRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
G + +R + + D +G +LD +T I P
Sbjct: 423 REKAKARGDF---QKLREKQQLEEDLRG---YLDWITQAEDIDP 460
Score = 90.5 bits (223), Expect = 4e-16
Identities = 86/351 (24%), Positives = 154/351 (43%), Gaps = 28/351 (7%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+ I +I N +ALA+ Y Q + Y + L + + +F VFT+E VLK+ A F
Sbjct: 1274 FEYGIFVLIMINTVALAM--KYHGQSASYSDAL-DYLNIIFTGVFTVEFVLKLAAFRF-- 1328
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKALRAFRVLRPLRLVSGVPSL 621
Y +AWN+ DFIIV+ + I ++++ + R FRV+R ++L+S +
Sbjct: 1329 --KNYFGDAWNVFDFIIVLGSFIDIIYAEVNPGKAFISINFFRLFRVMRLIKLLSRGEGI 1386
Query: 622 QVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKL---HSTCIDP---------- 762
+ +L +++ L ++ALL++ + IYA+IG+++F G++ ++T I P
Sbjct: 1387 RTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMF-GRIKLDYNTQIHPNNNFQTFPHA 1445
Query: 763 -------ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGIT 921
ATG+ Q+ C T A KC P+
Sbjct: 1446 VLVLFRSATGESWQEIMLACSDKT---AVKCDPA-------------------------- 1476
Query: 922 NFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVL 1101
+E +V + G ++ ++YF++ IL SF ++NL + V+
Sbjct: 1477 ----------------VIEHGVNVTDAEANRCGNDFAYVYFISFYILCSFLIINLFVAVI 1520
Query: 1102 SGEF---SKEREKARARGLFQKFREKQQLEEDLKG---YLDWITQAEDIEP 1236
F +++ L + R + + + KG +LD +T I P
Sbjct: 1521 MDNFDYLTRDWSILGPHHLDEFVRLWSEYDPEAKGRIKHLDVVTLLRKISP 1571
Score = 72.8 bits (177), Expect = 9e-11
Identities = 56/256 (21%), Positives = 101/256 (38%), Gaps = 20/256 (7%)
Frame = +1
Query: 1408 VKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGF 1587
V SQ F + +++GQS N+ F +F++E +LK+ + F
Sbjct: 1269 VTSQAFEYGIFVLIMINTVALAMKYHGQSASYSDALDYLNIIFTGVFTVEFVLKLAAFRF 1328
Query: 1588 TTYTTSQFNRFDCFVVISSILEFVLVYFDLMKP-LGVSVLRSARLLRIFKVTKYWTXXXX 1764
Y +N FD +V+ S ++ + + K + ++ R R++R+ K+
Sbjct: 1329 KNYFGDAWNVFDFIIVLGSFIDIIYAEVNPGKAFISINFFRLFRVMRLIKLLSRGEGIRT 1388
Query: 1765 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGG-KFNFNPQQPKPRANFDTFVQALL 1941
GMQ+FG K ++N Q P NF TF A+L
Sbjct: 1389 LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGRIKLDYNTQI-HPNNNFQTFPHAVL 1447
Query: 1942 TVFQILTGEDWNTVMY----------------HGIESFGGVGTL--GVIVCIYYIVLFIC 2067
+F+ TGE W +M HG+ +Y+I +I
Sbjct: 1448 VLFRSATGESWQEIMLACSDKTAVKCDPAVIEHGVNVTDAEANRCGNDFAYVYFISFYIL 1507
Query: 2068 GNYILLNVFLAIAVDN 2115
+++++N+F+A+ +DN
Sbjct: 1508 CSFLIINLFVAVIMDN 1523
Score = 54.7 bits (130), Expect = 3e-05
Identities = 53/252 (21%), Positives = 110/252 (43%), Gaps = 6/252 (2%)
Frame = +1
Query: 2359 FRVFCNMVVNHSYFTNAVLFCILVSSAMLAAE---DPLQANSTRNMILNYFDYFFTSVFT 2529
+R FC +V F V+ + +++ +L +E P+ + + + + FF +FT
Sbjct: 514 YRRFCRRIVKSQAFYWGVIVLVFLNTVVLTSEHYKQPVWLDDFQAIA----NLFFVVLFT 569
Query: 2530 VEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXX 2709
+E+ +K+ G +G F + FN D VV S+ +L+ +
Sbjct: 570 MEMLVKMYSLGF---QGYFV-SLFNRFDSFVVVCSILEVILQYTNVFPPLGISVLRCARL 625
Query: 2710 XXAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLS 2880
+ L+++V ++ ++++I +++L+ F+ +FA++G+QLF G F
Sbjct: 626 LRVFKATRYWSSLRNLVASLLNSMRSIASLLLLLFLFIVIFALLGMQLFGGKF------- 678
Query: 2881 KMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLY 3060
++ G+ KP S NFD +++++F + T E W ++Y
Sbjct: 679 ------------NFPQGE--KPRS----------NFDTFWPSLLTVFQILTGEDWNAVMY 714
Query: 3061 VAIDSNEEDKGP 3096
I + + K P
Sbjct: 715 DGIRAYDGVKFP 726
Score = 47.0 bits (110), Expect = 0.005
Identities = 48/231 (20%), Positives = 84/231 (35%), Gaps = 38/231 (16%)
Frame = +1
Query: 1531 FFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVS 1698
FF +F++E+++K+ + G ++ S F+ D VV S++ F L D V
Sbjct: 992 FFTSVFTIEIIIKIITYGLMLHKGSFCRSLFSILDLVVVAVSLISFPL---DNQAISVVK 1048
Query: 1699 VLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF 1878
+LR R+LR + G+Q+F GKF
Sbjct: 1049 ILRVLRVLRPLRAINRAKGLKHVVQCVIVALRTIYNIMLVTFLLNFMFSVMGVQLFKGKF 1108
Query: 1879 N------------------------FNPQQPKPRA------NFDTFVQALLTVFQILTGE 1968
+ FN + R NFD +LT+F + T E
Sbjct: 1109 SMCTDESKLTEDECQGNFITYDDGKFNSPNIEERKWKKNDFNFDDVSNGMLTLFTVSTFE 1168
Query: 1969 DWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
W ++Y I+S G + V ++Y + I + ++N+F+ +
Sbjct: 1169 GWPGLLYKSIDSHAEGKGPIQNSKPAVAVFYFIFIIVIAFFMMNIFVGFVI 1219
>gi|31206783|ref|XP_312358.1| ENSANGP00000023154 [Anopheles gambiae]
gi|30177475|gb|EAA44910.1| ENSANGP00000023154 [Anopheles gambiae str.
PEST]
Length = 1515
Score = 1145 bits (2962), Expect = 0.0
Identities = 654/1516 (43%), Positives = 863/1516 (56%), Gaps = 67/1516 (4%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N IRK I+EW PFE+ +L I ANC+ LA+ + P D LE E F+ +
Sbjct: 26 DNIIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPHGDKTILAQKLEKTEAYFLGI 85
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F +E LKI+A+GF+ H +YLRN WNI+DF +VV G ++ K D++ LRA R
Sbjct: 86 FCVEASLKILALGFVMHKHSYLRNIWNIMDFFVVVTGFITLFPQKGP--EVDLRTLRAIR 143
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQVVL +I++AM PLL I LLVLF I+I+AIIGLE + G LH +C
Sbjct: 144 VLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHRSCYS 203
Query: 760 PATGQLAQKD---PTPCGTDTEG----SAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGI 918
K+ PTPC D + A+ C SDS C W GPN GI
Sbjct: 204 LEDISQIVKEGEFPTPCNADNDTIAPTGAYVCNSSDST--------CIEQ--WEGPNFGI 253
Query: 919 TNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGV 1098
T+FDN G AMLTVFQC+++EGWT ++YW NDA+G + WIYFV L++LGSFF+LNLVLGV
Sbjct: 254 TSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSTFNWIYFVPLIVLGSFFMLNLVLGV 313
Query: 1099 LSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPV--- 1269
LSGEF+KEREK R F K R +QQLE++L GY++WI +AE++ E E+E +
Sbjct: 314 LSGEFAKEREKVENRQEFLKLRRQQQLEKELNGYVEWICKAEEVILAEERTTEEERLHIM 373
Query: 1270 -------AQTXXXXXXXXXXXXXXXXXXPS-------------KWAARMKRLEKLNXXXX 1389
A+ P K + K +
Sbjct: 374 EARRRAAAKRKKLKNLGKSKSTDTEEDDPDEDCGDDGYLKAKVKTQGKCKGFWRAEKRFR 433
Query: 1390 XXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLK 1569
VK+Q FYW EHYGQ WL F A F+ LF MEM +K
Sbjct: 434 FWIRHTVKTQWFYWFVIVLVFFNTVCVAVEHYGQPNWLTQFLYYAEYVFLGLFMMEMWIK 493
Query: 1570 MYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMK--PLGVSVLRSARLLRIFKVTK 1743
MY+LG Y S FNRFDC V+ SI E V + +K G+SVLR+ RLLRIFKVTK
Sbjct: 494 MYALGPRIYFESSFNRFDCVVISGSIFEVV---WSEVKGGSFGLSVLRALRLLRIFKVTK 550
Query: 1744 YWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDT 1923
YW+ GMQ+FGG+FN P NF+T
Sbjct: 551 YWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNL--PDGTPPTNFNT 608
Query: 1924 FVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAI 2103
F ALLTVFQILTGEDWN VMY GIES GG G+I +Y+I+L + GNY LLNVFLAI
Sbjct: 609 FPIALLTVFQILTGEDWNEVMYQGIESQGG-HKKGMIYSLYFIILVLFGNYTLLNVFLAI 667
Query: 2104 AVDNLADADSLTNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSARPRRMS 2283
AVDNLA+A LT A ++S P R +
Sbjct: 668 AVDNLANAQELT-AAEEEQLEENKEKQQMELDKEMEALHMQNDGSPPRVEVSSPSPTRGN 726
Query: 2284 --------------------EVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFT 2403
E+P KP+ SS+F+LS TN R + VVN YF
Sbjct: 727 GSGGSTKSKKKDEEKEEDDDEIPDGP--KPMLPYSSMFVLSPTNPIRCGAHWVVNLRYFD 784
Query: 2404 NAVLFCILVSSAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGS 2583
++ I +SS LAAEDP++ +S RN ILN+FDY FT VFT+E+ LK++ G++ H GS
Sbjct: 785 FFIMVVISLSSIALAAEDPVEEDSPRNKILNFFDYAFTGVFTIEMLLKIVDLGVILHPGS 844
Query: 2584 FCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXA------INRAKGLKH 2745
+ R +N++D +VV + SF S I R LK
Sbjct: 845 YLREFWNVMDAVVVICAAVSFGFDMTGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKA 904
Query: 2746 VVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYE 2925
V CV+ ++K + NI++V + QF+FA+I VQLF G FF C D SK T EC+G + Y
Sbjct: 905 VFDCVVNSLKNVINILIVYILFQFIFAVIAVQLFNGKFFYCTDDSKHTSEECKGHFFVY- 963
Query: 2926 DGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHN 3105
DG P + R W F++DNV AM++LF V T EGWPQ+L ++ + EDKGPI N
Sbjct: 964 DGADQLPRREPREWKTQSFHYDNVATAMLTLFAVQTGEGWPQVLQNSMAATYEDKGPIQN 1023
Query: 3106 SRQAVALXXXXXXXXXXXXXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAK 3285
R +++ +I+TFQ +GE E ++ E+DKNQ+ CI+F + A+
Sbjct: 1024 FRIEMSIFYIVYFIVFPFFFVNIFVALIIITFQEQGEAELQDGEIDKNQKSCIDFTIGAR 1083
Query: 3286 PHRRYIP--RNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFN 3459
P RY+P RN +Y+VW V S FEY I ++IV NT+ L K++ + FE L N
Sbjct: 1084 PLERYMPNKRNSFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGKEFEKSLKYLN 1143
Query: 3460 LIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINF 3639
+ FTG+F+ E +LKI+ KN+ D WN+FD + V+GS ID +L G N ++ F
Sbjct: 1144 MGFTGMFSVETILKIIGFGVKNFFKDPWNIFDFITVIGSIIDALVLEL---GENSFNVGF 1200
Query: 3640 FRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVAL 3819
RLFR RL+KLL +G IR LLWTF++SF+ALPYV LLI +LFFIYA+IGMQ FG + L
Sbjct: 1201 LRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIEL 1260
Query: 3820 DDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNE 3999
D +SI R+NNF SF +++LFR ATGE+W +IML+C CDP ++ ++
Sbjct: 1261 DPESSITRHNNFRSFVQGLMLLFRCATGESWPNIMLACLKGRP--CDPRANKPNE----- 1313
Query: 4000 SRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEY 4179
CG+ AY YF+SF CSFL++NLFVAVIMDNFDYLTRD SILG HHL+EFVR+W+EY
Sbjct: 1314 -TCGSTLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGAHHLDEFVRIWAEY 1372
Query: 4180 DPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFA 4359
DP+A G+I + ++ +L+ + PPLGFG CP+RLA K+L+ MNMPL+++G V F TLFA
Sbjct: 1373 DPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDAEGKVAFTTTLFA 1432
Query: 4360 LVRTNL--KIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVP-----PAGKEDDVTVG 4518
L+R NL K+ T +D+A+ +LR I IW K +LD +VP AGK +TVG
Sbjct: 1433 LIRENLNIKMRTAEEMDQADAELRHTISHIWPLQAKKMLDLLVPLNEELNAGK---LTVG 1489
Query: 4519 KFYATFLIQDYFRRFK 4566
K YA LI + +R K
Sbjct: 1490 KIYAGLLILESWRNTK 1505
Score = 95.1 bits (235), Expect = 2e-17
Identities = 70/268 (26%), Positives = 116/268 (43%), Gaps = 18/268 (6%)
Frame = +1
Query: 2326 SSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNY 2499
+SLFILS N R + ++ F AVL I+ + +LA E+ L + L
Sbjct: 18 TSLFILSEDNIIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPHGDKTILAQKLEK 77
Query: 2500 FDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXX 2679
+ +F +F VE +LK++ G V HK S+ RN +N++D VV + +
Sbjct: 78 TEAYFLGIFCVEASLKILALGFVMHKHSYLRNIWNIMDFFVVVTGFITLFPQKGPEVDLR 137
Query: 2680 XXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTF 2859
++ L+ V++ +I A+ + I L+ +FAIIG++ + G
Sbjct: 138 TLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGAL 197
Query: 2860 F-LCNDLSKMTEAECRGEYIH--YEDGDPTKPVSKK----------RVWSNNDF---NFD 2991
C L +++ GE+ D D P W +F +FD
Sbjct: 198 HRSCYSLEDISQIVKEGEFPTPCNADNDTIAPTGAYVCNSSDSTCIEQWEGPNFGITSFD 257
Query: 2992 NVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
N+G AM+++F T EGW +LY D+
Sbjct: 258 NIGFAMLTVFQCITMEGWTAILYWTNDA 285
>gi|45554921|ref|NP_996416.1| CG1522-PF [Drosophila melanogaster]
gi|45446925|gb|AAS65325.1| CG1522-PF [Drosophila melanogaster]
Length = 1851
Score = 1144 bits (2958), Expect = 0.0
Identities = 666/1569 (42%), Positives = 887/1569 (56%), Gaps = 55/1569 (3%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+NPIRK I+EW PFE+ +L I ANC+ LA+ + P D LE E F+ +
Sbjct: 24 DNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFLCI 83
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F +E LKI+A+G + H +YLRN WNI+DF +VV G + TI ++ +I D++ LR+FR
Sbjct: 84 FCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGAM-TIFAEANID-VDLRMLRSFR 141
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI- 756
VLRPL+LVS +PSLQVVL +I++AM PLL I LLVLF I+I+AIIGLE + G LH TC
Sbjct: 142 VLRPLKLVSRIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYS 201
Query: 757 --DPATGQLAQKDPTPCGTDT----EGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGI 918
DP + TPC TD +F C + S+ C W GPN+GI
Sbjct: 202 LEDPNKLVKEGESETPCNTDNILEKATGSFVCNNTTSM--------CLEK--WEGPNSGI 251
Query: 919 TNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGV 1098
T+FDN G AMLTVFQC+++EGWT ++YW NDA+G + WIYFV L+++GSFF+LNLVLGV
Sbjct: 252 TSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGV 311
Query: 1099 LSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPV--- 1269
LSGEF+KEREK R F K R +QQLE +L GY++WI +AE++ E E+E +
Sbjct: 312 LSGEFAKEREKVENRQEFLKLRRQQQLERELNGYVEWICKAEEVILAEERTTEEEKMHIM 371
Query: 1270 -----------------------AQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNX 1380
+ P R EK
Sbjct: 372 EARRRNAAKRKKLKSLGKSKSTDTEEEEAEEDYGDDGYLKTRSKPQGSCTGFWRAEK--- 428
Query: 1381 XXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEM 1560
VK+Q FYW EHYGQ +L F A F+ LF EM
Sbjct: 429 RFRFWIRHTVKTQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEM 488
Query: 1561 LLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMK--PLGVSVLRSARLLRIFK 1734
+KMY+LG Y S FNRFDC V+ SI E V + +K G+SVLR+ RLLRIFK
Sbjct: 489 FIKMYALGPRIYFESSFNRFDCVVISGSIFE---VIWSEVKGGSFGLSVLRALRLLRIFK 545
Query: 1735 VTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRAN 1914
VTKYW+ GMQ+FGG+FN P+ N
Sbjct: 546 VTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNLPGGTPE--TN 603
Query: 1915 FDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVF 2094
F+TF ALLTVFQILTGEDWN VMY GI S GG G+I IY+IVL + GNY LLNVF
Sbjct: 604 FNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQK-GMIYSIYFIVLVLFGNYTLLNVF 662
Query: 2095 LAIAVDNLADADSLTNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSARPR 2274
LAIAVDNLA+A LT A + ++ +
Sbjct: 663 LAIAVDNLANAQELTAAEEEQVEEDKEKQLQELEKEMEALQADGVHVENGDGAVAPSKSK 722
Query: 2275 -------RMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVS 2433
+ E KP+ SS+FILS TN R + VVN YF ++ I +S
Sbjct: 723 GKKKEEEKKEEEEVTEGPKPMLPYSSMFILSPTNPIRRGAHWVVNLPYFDFFIMVVISMS 782
Query: 2434 SAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLD 2613
S LAAEDP++ NS RN ILNYFDY FT VFT+E+ LK++ G++ H GS+ R +N++D
Sbjct: 783 SIALAAEDPVRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMD 842
Query: 2614 ILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXA------INRAKGLKHVVQCVIVAVK 2775
+VV + SF S I R LK V CV+ ++K
Sbjct: 843 AVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLK 902
Query: 2776 TIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSK 2955
+ NI++V + QF+F++IGVQLF G FF C D SK T AEC+G Y YE+ D P +
Sbjct: 903 NVVNILIVYILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFKYEE-DELLPKQE 961
Query: 2956 KRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXX 3135
RVW F++DNV AM++LF V T EGWPQ+L ++ + ED+GPI N R +++
Sbjct: 962 LRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYI 1021
Query: 3136 XXXXXXXXXXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR 3315
+I+TFQ +GE E ++ E+DKNQ+ CI+F + A+P RY+P+NR
Sbjct: 1022 VYFIVFPFFFVNIFVALIIITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNR 1081
Query: 3316 --LQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFE 3489
+Y+VW V S FEY I ++IV NT+ L K++ +E L N+ FTG+F+ E
Sbjct: 1082 NTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVE 1141
Query: 3490 AVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLV 3669
VLKI+ KN+ D WN+FDL+ V+GS +D + + +N I++ F RLFR RL+
Sbjct: 1142 TVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDALWMEFGHDDSNSINVGFLRLFRAARLI 1201
Query: 3670 KLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDD-STSIHRN 3846
KLL +G IR LLWTF++SF+ALPYV LLI +LFFIYA+IGMQ FG + L SI R+
Sbjct: 1202 KLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSITRH 1261
Query: 3847 NNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAY 4026
NNF SF +++LFR ATGEAW +IML+C + CD DD K CG+ AY
Sbjct: 1262 NNFQSFIQGVMLLFRCATGEAWPNIMLAC--LKGKACD---DDAEKA--PGEYCGSTLAY 1314
Query: 4027 PYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIK 4206
YF+SF CSFL++NLFVAVIMDNFDYLTRD SILG HHL+EFVR+W+EYDP+A G+I
Sbjct: 1315 AYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGAHHLDEFVRIWAEYDPNATGKIH 1374
Query: 4207 HLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNL--K 4380
+ ++ +L+ + PPLGFG CP+RLA K+L+ MNMPL+ + V F TLFAL+R NL K
Sbjct: 1375 YTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSIK 1434
Query: 4381 IYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGK--EDDVTVGKFYATFLIQDYF 4554
+ +D+A+ +LR I IW K +L+ +VPP+ + + ++VGK YA FLI + +
Sbjct: 1435 MRAPEEMDQADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGFLILESW 1494
Query: 4555 RRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDEPEPQH 4734
R + G L + P + LQ R H L A +G+L ++ H
Sbjct: 1495 RSTR-------FGQLDSGMPM-LELQDASR--HPSQESLTGADAGHLHPGHSYMN---GH 1541
Query: 4735 RRPHSLFNN 4761
RR SL +N
Sbjct: 1542 RRSPSLRHN 1550
Score = 96.7 bits (239), Expect = 6e-18
Identities = 71/268 (26%), Positives = 122/268 (45%), Gaps = 18/268 (6%)
Frame = +1
Query: 2326 SSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNY 2499
+SLFIL+ N R + ++ F AVL I+ + +LA E+ L + L
Sbjct: 16 TSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEK 75
Query: 2500 FDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXX 2679
+ +F +F VE +LK++ GLV HK S+ RN +N++D VV + +
Sbjct: 76 TEAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGAMTIFAEANIDVDLR 135
Query: 2680 XXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKG-- 2853
++R L+ V++ +I A+ + I L+ +FAIIG++ + G
Sbjct: 136 MLRSFRVLRPLKLVSRIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGAL 195
Query: 2854 --TFFLCNDLSKM-----TEAECRGEYI------HYEDGDPTKPVSKKRVWSNNDF-NFD 2991
T + D +K+ +E C + I + + T +K N+ +FD
Sbjct: 196 HKTCYSLEDPNKLVKEGESETPCNTDNILEKATGSFVCNNTTSMCLEKWEGPNSGITSFD 255
Query: 2992 NVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
N+G AM+++F T EGW +LY D+
Sbjct: 256 NIGFAMLTVFQCITMEGWTAILYWTNDA 283
>gi|45554951|ref|NP_996418.1| CG1522-PD [Drosophila melanogaster]
gi|45446924|gb|AAS65324.1| CG1522-PD [Drosophila melanogaster]
Length = 1848
Score = 1142 bits (2954), Expect = 0.0
Identities = 667/1569 (42%), Positives = 888/1569 (56%), Gaps = 55/1569 (3%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+NPIRK I+EW PFE+ +L I ANC+ LA+ + P D LE E F+ +
Sbjct: 24 DNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFLCI 83
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F +E LKI+A+G + H +YLRN WNI+DF +VV G + TI ++ +I D++ LR+FR
Sbjct: 84 FCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGAM-TIFAEANID-VDLRMLRSFR 141
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI- 756
VLRPL+LVS +PSLQVVL +I++AM PLL I LLVLF I+I+AIIGLE + G LH TC
Sbjct: 142 VLRPLKLVSRIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYS 201
Query: 757 --DPATGQLAQKDPTPCGTDT----EGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGI 918
DP + TPC TD +F C + S+ C W GPN+GI
Sbjct: 202 LEDPNKLVKEGESETPCNTDNILEKATGSFVCNNTTSM--------CLEK--WEGPNSGI 251
Query: 919 TNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGV 1098
T+FDN G AMLTVFQC+++EGWT ++YW NDA+G + WIYFV L+++GSFF+LNLVLGV
Sbjct: 252 TSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGV 311
Query: 1099 LSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPV--- 1269
LSGEF+KEREK R F K R +QQLE +L GY++WI +AE++ E E+E +
Sbjct: 312 LSGEFAKEREKVENRQEFLKLRRQQQLERELNGYVEWICKAEEVILAEERTTEEEKMHIM 371
Query: 1270 -----------------------AQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNX 1380
+ P R EK
Sbjct: 372 EARRRNAAKRKKLKSLGKSKSTDTEEEEAEEDYGDDGYLKTRSKPQGSCTGFWRAEK--- 428
Query: 1381 XXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEM 1560
VK+Q FYW EHYGQ +L F A F+ LF EM
Sbjct: 429 RFRFWIRHTVKTQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEM 488
Query: 1561 LLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMK--PLGVSVLRSARLLRIFK 1734
+KMY+LG Y S FNRFDC V+ SI E V + +K G+SVLR+ RLLRIFK
Sbjct: 489 FIKMYALGPRIYFESSFNRFDCVVISGSIFE---VIWSEVKGGSFGLSVLRALRLLRIFK 545
Query: 1735 VTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRAN 1914
VTKYW+ GMQ+FGG+FN P+ N
Sbjct: 546 VTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNLPGGTPE--TN 603
Query: 1915 FDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVF 2094
F+TF ALLTVFQILTGEDWN VMY GI S GG G+I IY+IVL + GNY LLNVF
Sbjct: 604 FNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQK-GMIYSIYFIVLVLFGNYTLLNVF 662
Query: 2095 LAIAVDNLADADSLTNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSARPR 2274
LAIAVDNLA+A LT A + ++ +
Sbjct: 663 LAIAVDNLANAQELTAAEEEQVEEDKEKQLQELEKEMEALQADGVHVENGDGAVAPSKSK 722
Query: 2275 -------RMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVS 2433
+ E KP+ SS+FILS TN R + VVN YF ++ I +S
Sbjct: 723 GKKKEEEKKEEEEVTEGPKPMLPYSSMFILSPTNPIRRGAHWVVNLPYFDFFIMVVISMS 782
Query: 2434 SAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLD 2613
S LAAEDP++ NS RN ILNYFDY FT VFT+E+ LK++ G++ H GS+ R +N++D
Sbjct: 783 SIALAAEDPVRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMD 842
Query: 2614 ILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXA------INRAKGLKHVVQCVIVAVK 2775
+VV + SF S I R LK V CV+ ++K
Sbjct: 843 AVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLK 902
Query: 2776 TIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSK 2955
+ NI++V + QF+F++IGVQLF G FF C D SK T AEC+G Y YE+ D P +
Sbjct: 903 NVVNILIVYILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFKYEE-DELLPKQE 961
Query: 2956 KRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXX 3135
RVW F++DNV AM++LF V T EGWPQ+L ++ + ED+GPI N R +++
Sbjct: 962 LRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYI 1021
Query: 3136 XXXXXXXXXXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR 3315
+I+TFQ +GE E ++ E+DKNQ+ CI+F + A+P RY+P+NR
Sbjct: 1022 VYFIVFPFFFVNIFVALIIITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNR 1081
Query: 3316 --LQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFE 3489
+Y+VW V S FEY I ++IV NT+ L K++ +E L N+ FTG+F+ E
Sbjct: 1082 NTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVE 1141
Query: 3490 AVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLV 3669
VLKI+ KN+ D WN+FDL+ V+GS +D + + G+N I++ F RLFR RL+
Sbjct: 1142 TVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDALWMEF---GSNSINVGFLRLFRAARLI 1198
Query: 3670 KLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDD-STSIHRN 3846
KLL +G IR LLWTF++SF+ALPYV LLI +LFFIYA+IGMQ FG + L SI R+
Sbjct: 1199 KLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSITRH 1258
Query: 3847 NNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAY 4026
NNF SF +++LFR ATGEAW +IML+C + CD DD K CG+ AY
Sbjct: 1259 NNFQSFIQGVMLLFRCATGEAWPNIMLACLKGK--ACD---DDAEKAP--GEYCGSTLAY 1311
Query: 4027 PYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIK 4206
YF+SF CSFL++NLFVAVIMDNFDYLTRD SILG HHL+EFVR+W+EYDP+A G+I
Sbjct: 1312 AYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGAHHLDEFVRIWAEYDPNATGKIH 1371
Query: 4207 HLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNL--K 4380
+ ++ +L+ + PPLGFG CP+RLA K+L+ MNMPL+ + V F TLFAL+R NL K
Sbjct: 1372 YTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSIK 1431
Query: 4381 IYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGK--EDDVTVGKFYATFLIQDYF 4554
+ +D+A+ +LR I IW K +L+ +VPP+ + + ++VGK YA FLI + +
Sbjct: 1432 MRAPEEMDQADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGFLILESW 1491
Query: 4555 RRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDEPEPQH 4734
R + G L + P + LQ R H L A +G+L ++ H
Sbjct: 1492 RSTR-------FGQLDSGMPM-LELQDASR--HPSQESLTGADAGHLHPGHSYMN---GH 1538
Query: 4735 RRPHSLFNN 4761
RR SL +N
Sbjct: 1539 RRSPSLRHN 1547
Score = 96.7 bits (239), Expect = 6e-18
Identities = 71/268 (26%), Positives = 122/268 (45%), Gaps = 18/268 (6%)
Frame = +1
Query: 2326 SSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNY 2499
+SLFIL+ N R + ++ F AVL I+ + +LA E+ L + L
Sbjct: 16 TSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEK 75
Query: 2500 FDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXX 2679
+ +F +F VE +LK++ GLV HK S+ RN +N++D VV + +
Sbjct: 76 TEAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGAMTIFAEANIDVDLR 135
Query: 2680 XXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKG-- 2853
++R L+ V++ +I A+ + I L+ +FAIIG++ + G
Sbjct: 136 MLRSFRVLRPLKLVSRIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGAL 195
Query: 2854 --TFFLCNDLSKM-----TEAECRGEYI------HYEDGDPTKPVSKKRVWSNNDF-NFD 2991
T + D +K+ +E C + I + + T +K N+ +FD
Sbjct: 196 HKTCYSLEDPNKLVKEGESETPCNTDNILEKATGSFVCNNTTSMCLEKWEGPNSGITSFD 255
Query: 2992 NVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
N+G AM+++F T EGW +LY D+
Sbjct: 256 NIGFAMLTVFQCITMEGWTAILYWTNDA 283
>gi|45554962|ref|NP_996419.1| CG1522-PC [Drosophila melanogaster]
gi|45446922|gb|AAS65322.1| CG1522-PC [Drosophila melanogaster]
Length = 1848
Score = 1139 bits (2947), Expect = 0.0
Identities = 666/1569 (42%), Positives = 886/1569 (56%), Gaps = 55/1569 (3%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+NPIRK I+EW PFE+ +L I ANC+ LA+ + P D LE E F+ +
Sbjct: 24 DNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFLCI 83
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F +E LKI+A+G + H +YLRN WNI+DF +VV G + T ++ + D++ LRA R
Sbjct: 84 FCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFM-TQYPQIGPE-VDLRTLRAIR 141
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI- 756
VLRPL+LVSG+PSLQVVL +I++AM PLL I LLVLF I+I+AIIGLE + G LH TC
Sbjct: 142 VLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYS 201
Query: 757 --DPATGQLAQKDPTPCGTDT----EGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGI 918
DP + TPC TD +F C + S+ C W GPN+GI
Sbjct: 202 LEDPNKLVKEGESETPCNTDNILEKATGSFVCNNTTSM--------CLEK--WEGPNSGI 251
Query: 919 TNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGV 1098
T+FDN G AMLTVFQC+++EGWT ++YW NDA+G + WIYFV L+++GSFF+LNLVLGV
Sbjct: 252 TSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGV 311
Query: 1099 LSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPV--- 1269
LSGEF+KEREK R F K R +QQLE +L GY++WI +AE++ E E+E +
Sbjct: 312 LSGEFAKEREKVENRQEFLKLRRQQQLERELNGYVEWICKAEEVILAEERTTEEEKMHIM 371
Query: 1270 -----------------------AQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNX 1380
+ P R EK
Sbjct: 372 EARRRNAAKRKKLKSLGKSKSTDTEEEEAEEDYGDDGYLKTRSKPQGSCTGFWRAEK--- 428
Query: 1381 XXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEM 1560
VK+Q FYW EHYGQ +L F A F+ LF EM
Sbjct: 429 RFRFWIRHTVKTQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEM 488
Query: 1561 LLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMK--PLGVSVLRSARLLRIFK 1734
+KMY+LG Y S FNRFDC V+ SI E V + +K G+SVLR+ RLLRIFK
Sbjct: 489 FIKMYALGPRIYFESSFNRFDCVVISGSIFE---VIWSEVKGGSFGLSVLRALRLLRIFK 545
Query: 1735 VTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRAN 1914
VTKYW+ GMQ+FGG+FN P+ N
Sbjct: 546 VTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNLPGGTPE--TN 603
Query: 1915 FDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVF 2094
F+TF ALLTVFQILTGEDWN VMY GI S GG G+I IY+IVL + GNY LLNVF
Sbjct: 604 FNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQK-GMIYSIYFIVLVLFGNYTLLNVF 662
Query: 2095 LAIAVDNLADADSLTNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSARPR 2274
LAIAVDNLA+A LT A + ++ +
Sbjct: 663 LAIAVDNLANAQELTAAEEEQVEEDKEKQLQELEKEMEALQADGVHVENGDGAVAPSKSK 722
Query: 2275 -------RMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVS 2433
+ E KP+ SS+FILS TN R + VVN YF ++ I +S
Sbjct: 723 GKKKEEEKKEEEEVTEGPKPMLPYSSMFILSPTNPIRRGAHWVVNLPYFDFFIMVVISMS 782
Query: 2434 SAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLD 2613
S LAAEDP++ NS RN ILNYFDY FT VFT+E+ LK++ G++ H GS+ R +N++D
Sbjct: 783 SIALAAEDPVRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMD 842
Query: 2614 ILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXA------INRAKGLKHVVQCVIVAVK 2775
+VV + SF S I R LK V CV+ ++K
Sbjct: 843 AVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLK 902
Query: 2776 TIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSK 2955
+ NI++V + QF+F++IGVQLF G FF C D SK T AEC+G Y YE+ D P +
Sbjct: 903 NVVNILIVYILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFKYEE-DELLPKQE 961
Query: 2956 KRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXX 3135
RVW F++DNV AM++LF V T EGWPQ+L ++ + ED+GPI N R +++
Sbjct: 962 LRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYI 1021
Query: 3136 XXXXXXXXXXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR 3315
+I+TFQ +GE E ++ E+DKNQ+ CI+F + A+P RY+P+NR
Sbjct: 1022 VYFIVFPFFFVNIFVALIIITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNR 1081
Query: 3316 --LQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFE 3489
+Y+VW V S FEY I ++IV NT+ L K++ +E L N+ FTG+F+ E
Sbjct: 1082 NTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVE 1141
Query: 3490 AVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLV 3669
VLKI+ KN+ D WN+FDL+ V+GS +D + + G+N I++ F RLFR RL+
Sbjct: 1142 TVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDALWMEF---GSNSINVGFLRLFRAARLI 1198
Query: 3670 KLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDD-STSIHRN 3846
KLL +G IR LLWTF++SF+ALPYV LLI +LFFIYA+IGMQ FG + L SI R+
Sbjct: 1199 KLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSITRH 1258
Query: 3847 NNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAY 4026
NNF SF +++LFR ATGEAW +IML+C + CD DD K CG+ AY
Sbjct: 1259 NNFQSFIQGVMLLFRCATGEAWPNIMLACLKGK--ACD---DDAEKAP--GEYCGSTLAY 1311
Query: 4027 PYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIK 4206
YF+SF CSFL++NLFVAVIMDNFDYLTRD SILG HHL+EFVR+W+EYDP+A G+I
Sbjct: 1312 AYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGAHHLDEFVRIWAEYDPNATGKIH 1371
Query: 4207 HLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNL--K 4380
+ ++ +L+ + PPLGFG CP+RLA K+L+ MNMPL+ + V F TLFAL+R NL K
Sbjct: 1372 YTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSIK 1431
Query: 4381 IYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGK--EDDVTVGKFYATFLIQDYF 4554
+ +D+A+ +LR I IW K +L+ +VPP+ + + ++VGK YA FLI + +
Sbjct: 1432 MRAPEEMDQADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGFLILESW 1491
Query: 4555 RRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDEPEPQH 4734
R + G L + P + LQ R H L A +G+L ++ H
Sbjct: 1492 RSTR-------FGQLDSGMPM-LELQDASR--HPSQESLTGADAGHLHPGHSYMN---GH 1538
Query: 4735 RRPHSLFNN 4761
RR SL +N
Sbjct: 1539 RRSPSLRHN 1547
Score = 92.8 bits (229), Expect = 8e-17
Identities = 73/271 (26%), Positives = 125/271 (45%), Gaps = 21/271 (7%)
Frame = +1
Query: 2326 SSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNY 2499
+SLFIL+ N R + ++ F AVL I+ + +LA E+ L + L
Sbjct: 16 TSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEK 75
Query: 2500 FDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXX 2679
+ +F +F VE +LK++ GLV HK S+ RN +N++D VV +T F+ + +
Sbjct: 76 TEAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVV---VTGFMTQYPQIGPEV 132
Query: 2680 XXXXXXXXXXXXAINRAKG---LKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFK 2850
+ G L+ V++ +I A+ + I L+ +FAIIG++ +
Sbjct: 133 DLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYS 192
Query: 2851 G----TFFLCNDLSKM-----TEAECRGEYI------HYEDGDPTKPVSKKRVWSNNDF- 2982
G T + D +K+ +E C + I + + T +K N+
Sbjct: 193 GALHKTCYSLEDPNKLVKEGESETPCNTDNILEKATGSFVCNNTTSMCLEKWEGPNSGIT 252
Query: 2983 NFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
+FDN+G AM+++F T EGW +LY D+
Sbjct: 253 SFDNIGFAMLTVFQCITMEGWTAILYWTNDA 283
>gi|45554974|ref|NP_996420.1| CG1522-PB [Drosophila melanogaster]
gi|45446926|gb|AAS65326.1| CG1522-PB [Drosophila melanogaster]
Length = 1848
Score = 1133 bits (2931), Expect = 0.0
Identities = 664/1569 (42%), Positives = 883/1569 (55%), Gaps = 55/1569 (3%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+NPIRK I+EW PFE+ +L I ANC+ LA+ + P D LE E F+ +
Sbjct: 24 DNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFLCI 83
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F +E LKI+A+G + H +YLRN WNI+DF +VV G + TI ++ +I D++ LR+FR
Sbjct: 84 FCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGAM-TIFAEANID-VDLRMLRSFR 141
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI- 756
VLRPL+LVS +PSLQVVL +I++AM PLL I LLVLF I+I+AIIGLE + G LH TC
Sbjct: 142 VLRPLKLVSRIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYS 201
Query: 757 --DPATGQLAQKDPTPCGTDT----EGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGI 918
DP + TPC TD +F C + S+ C W GPN+GI
Sbjct: 202 LEDPNKLVKEGESETPCNTDNILEKATGSFVCNNTTSM--------CLEK--WEGPNSGI 251
Query: 919 TNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGV 1098
T+FDN G AMLTVFQC+++EGWT ++YW NDA+G + WIYFV L+++GSFF+LNLVLGV
Sbjct: 252 TSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGV 311
Query: 1099 LSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPV--- 1269
LSGEFS ER + R FQK R + + + YLDWITQAE++ E E+E +
Sbjct: 312 LSGEFSNERNRVERRMEFQKCRFRAMFQTAMVSYLDWITQAEEVILAEERTTEEEKMHIM 371
Query: 1270 -----------------------AQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNX 1380
+ P R EK
Sbjct: 372 EARRRNAAKRKKLKSLGKSKSTDTEEEEAEEDYGDDGYLKTRSKPQGSCTGFWRAEK--- 428
Query: 1381 XXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEM 1560
VK+Q FYW EHYGQ +L F A F+ LF EM
Sbjct: 429 RFRFWIRHTVKTQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEM 488
Query: 1561 LLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMK--PLGVSVLRSARLLRIFK 1734
+KMY+LG Y S FNRFDC V+ SI E V + +K G+SVLR+ RLLRIFK
Sbjct: 489 FIKMYALGPRIYFESSFNRFDCVVISGSIFE---VIWSEVKGGSFGLSVLRALRLLRIFK 545
Query: 1735 VTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRAN 1914
VTKYW+ GMQ+FGG+FN P+ N
Sbjct: 546 VTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNLPGGTPE--TN 603
Query: 1915 FDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVF 2094
F+TF ALLTVFQILTGEDWN VMY GI S GG G+I IY+IVL + GNY LLNVF
Sbjct: 604 FNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQK-GMIYSIYFIVLVLFGNYTLLNVF 662
Query: 2095 LAIAVDNLADADSLTNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSARPR 2274
LAIAVDNLA+A LT A + ++ +
Sbjct: 663 LAIAVDNLANAQELTAAEEEQVEEDKEKQLQELEKEMEALQADGVHVENGDGAVAPSKSK 722
Query: 2275 -------RMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVS 2433
+ E KP+ SS+FILS TN R + VVN YF ++ I +S
Sbjct: 723 GKKKEEEKKEEEEVTEGPKPMLPYSSMFILSPTNPIRRGAHWVVNLPYFDFFIMVVISMS 782
Query: 2434 SAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLD 2613
S LAAEDP++ NS RN ILNYFDY FT VFT+E+ LK++ G++ H GS+ R +N++D
Sbjct: 783 SIALAAEDPVRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMD 842
Query: 2614 ILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXA------INRAKGLKHVVQCVIVAVK 2775
+VV + SF S I R LK V CV+ ++K
Sbjct: 843 AVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLK 902
Query: 2776 TIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSK 2955
+ NI++V + QF+F++IGVQLF G FF C D SK T AEC+G Y YE+ D P +
Sbjct: 903 NVVNILIVYILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFKYEE-DELLPKQE 961
Query: 2956 KRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXX 3135
RVW F++DNV AM++LF V T EGWPQ+L ++ + ED+GPI N R +++
Sbjct: 962 LRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYI 1021
Query: 3136 XXXXXXXXXXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR 3315
+I+TFQ +GE E ++ E+DKNQ+ CI+F + A+P RY+P+NR
Sbjct: 1022 VYFIVFPFFFVNIFVALIIITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNR 1081
Query: 3316 --LQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFE 3489
+Y+VW V S FEY I ++IV NT+ L K++ +E L N+ FTG+F+ E
Sbjct: 1082 NTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVE 1141
Query: 3490 AVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLV 3669
VLKI+ KN+ D WN+FDL+ V+GS +D + + G+N I++ F RLFR RL+
Sbjct: 1142 TVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDALWMEF---GSNSINVGFLRLFRAARLI 1198
Query: 3670 KLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDD-STSIHRN 3846
KLL +G IR LLWTF++SF+ALPYV LLI +LFFIYA+IGMQ FG + L SI R+
Sbjct: 1199 KLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSITRH 1258
Query: 3847 NNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAY 4026
NNF SF +++LFR ATGEAW +IML+C + CD DD K CG+ AY
Sbjct: 1259 NNFQSFIQGVMLLFRCATGEAWPNIMLACLKGK--ACD---DDAEKAP--GEYCGSTLAY 1311
Query: 4027 PYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIK 4206
YF+SF CSFL++NLFVAVIMDNFDYLTRD SILG HHL+EFVR+W+EYDP+A G+I
Sbjct: 1312 AYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGAHHLDEFVRIWAEYDPNATGKIH 1371
Query: 4207 HLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNL--K 4380
+ ++ +L+ + PPLGFG CP+RLA K+L+ MNMPL+ + V F TLFAL+R NL K
Sbjct: 1372 YTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSIK 1431
Query: 4381 IYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGK--EDDVTVGKFYATFLIQDYF 4554
+ +D+A+ +LR I IW K +L+ +VPP+ + + ++VGK YA FLI + +
Sbjct: 1432 MRAPEEMDQADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGFLILESW 1491
Query: 4555 RRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDEPEPQH 4734
R + G L + P + LQ R H L A +G+L ++ H
Sbjct: 1492 RSTR-------FGQLDSGMPM-LELQDASR--HPSQESLTGADAGHLHPGHSYMN---GH 1538
Query: 4735 RRPHSLFNN 4761
RR SL +N
Sbjct: 1539 RRSPSLRHN 1547
Score = 96.7 bits (239), Expect = 6e-18
Identities = 71/268 (26%), Positives = 122/268 (45%), Gaps = 18/268 (6%)
Frame = +1
Query: 2326 SSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNY 2499
+SLFIL+ N R + ++ F AVL I+ + +LA E+ L + L
Sbjct: 16 TSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEK 75
Query: 2500 FDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXX 2679
+ +F +F VE +LK++ GLV HK S+ RN +N++D VV + +
Sbjct: 76 TEAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGAMTIFAEANIDVDLR 135
Query: 2680 XXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKG-- 2853
++R L+ V++ +I A+ + I L+ +FAIIG++ + G
Sbjct: 136 MLRSFRVLRPLKLVSRIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGAL 195
Query: 2854 --TFFLCNDLSKM-----TEAECRGEYI------HYEDGDPTKPVSKKRVWSNNDF-NFD 2991
T + D +K+ +E C + I + + T +K N+ +FD
Sbjct: 196 HKTCYSLEDPNKLVKEGESETPCNTDNILEKATGSFVCNNTTSMCLEKWEGPNSGITSFD 255
Query: 2992 NVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
N+G AM+++F T EGW +LY D+
Sbjct: 256 NIGFAMLTVFQCITMEGWTAILYWTNDA 283
>gi|45554935|ref|NP_996417.1| CG1522-PE [Drosophila melanogaster]
gi|45446923|gb|AAS65323.1| CG1522-PE [Drosophila melanogaster]
Length = 1851
Score = 1132 bits (2928), Expect = 0.0
Identities = 662/1569 (42%), Positives = 880/1569 (55%), Gaps = 55/1569 (3%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+NPIRK I+EW PFE+ +L I ANC+ LA+ + P D LE E F+ +
Sbjct: 24 DNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFLCI 83
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F +E LKI+A+G + H +YLRN WNI+DF +VV G + T ++ + D++ LRA R
Sbjct: 84 FCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFM-TQYPQIGPE-VDLRTLRAIR 141
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI- 756
VLRPL+LVSG+PSLQVVL +I++AM PLL I LLVLF I+I+AIIGLE + G LH TC
Sbjct: 142 VLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYS 201
Query: 757 --DPATGQLAQKDPTPCGTDT----EGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGI 918
DP + TPC TD +F C + S+ C W GPN+GI
Sbjct: 202 LEDPNKLVKEGESETPCNTDNILEKATGSFVCNNTTSM--------CLEK--WEGPNSGI 251
Query: 919 TNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGV 1098
T+FDN G AMLTVFQC+++EGWT ++YW NDA+G + WIYFV L+++GSFF+LNLVLGV
Sbjct: 252 TSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGV 311
Query: 1099 LSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPV--- 1269
LSGEFS ER + R FQK R + + + YLDWITQAE++ E E+E +
Sbjct: 312 LSGEFSNERNRVERRMEFQKCRFRAMFQTAMVSYLDWITQAEEVILAEERTTEEEKMHIM 371
Query: 1270 -----------------------AQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNX 1380
+ P R EK
Sbjct: 372 EARRRNAAKRKKLKSLGKSKSTDTEEEEAEEDYGDDGYLKTRSKPQGSCTGFWRAEK--- 428
Query: 1381 XXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEM 1560
VK+Q FYW EHYGQ +L F A F+ LF EM
Sbjct: 429 RFRFWIRHTVKTQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEM 488
Query: 1561 LLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMK--PLGVSVLRSARLLRIFK 1734
+KMY+LG Y S FNRFDC V+ SI E V + +K G+SVLR+ RLLRIFK
Sbjct: 489 FIKMYALGPRIYFESSFNRFDCVVISGSIFE---VIWSEVKGGSFGLSVLRALRLLRIFK 545
Query: 1735 VTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRAN 1914
VTKYW+ GMQ+FGG+FN P+ N
Sbjct: 546 VTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNLPGGTPE--TN 603
Query: 1915 FDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVF 2094
F+TF ALLTVFQILTGEDWN VMY GI S GG G+I IY+IVL + GNY LLNVF
Sbjct: 604 FNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQK-GMIYSIYFIVLVLFGNYTLLNVF 662
Query: 2095 LAIAVDNLADADSLTNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSARPR 2274
LAIAVDNLA+A LT A + ++ +
Sbjct: 663 LAIAVDNLANAQELTAAEEEQVEEDKEKQLQELEKEMEALQADGVHVENGDGAVAPSKSK 722
Query: 2275 -------RMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVS 2433
+ E KP+ SS+FILS TN R + VVN YF ++ I +S
Sbjct: 723 GKKKEEEKKEEEEVTEGPKPMLPYSSMFILSPTNPIRRGAHWVVNLPYFDFFIMVVISMS 782
Query: 2434 SAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLD 2613
S LAAEDP++ NS RN ILNYFDY FT VFT+E+ LK++ G++ H GS+ R +N++D
Sbjct: 783 SIALAAEDPVRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMD 842
Query: 2614 ILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXA------INRAKGLKHVVQCVIVAVK 2775
+VV + SF S I R LK V CV+ ++K
Sbjct: 843 AVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLK 902
Query: 2776 TIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSK 2955
+ NI++V + QF+F++IGVQLF G FF C D SK T AEC+G Y YE+ D P +
Sbjct: 903 NVVNILIVYILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFKYEE-DELLPKQE 961
Query: 2956 KRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXX 3135
RVW F++DNV AM++LF V T EGWPQ+L ++ + ED+GPI N R +++
Sbjct: 962 LRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYI 1021
Query: 3136 XXXXXXXXXXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR 3315
+I+TFQ +GE E ++ E+DKNQ+ CI+F + A+P RY+P+NR
Sbjct: 1022 VYFIVFPFFFVNIFVALIIITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNR 1081
Query: 3316 --LQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFE 3489
+Y+VW V S FEY I ++IV NT+ L K++ +E L N+ FTG+F+ E
Sbjct: 1082 NTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVE 1141
Query: 3490 AVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLV 3669
VLKI+ KN+ D WN+FDL+ V+GS +D + + +N I++ F RLFR RL+
Sbjct: 1142 TVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDALWMEFGHDDSNSINVGFLRLFRAARLI 1201
Query: 3670 KLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDD-STSIHRN 3846
KLL +G IR LLWTF++SF+ALPYV LLI +LFFIYA+IGMQ FG + L SI R+
Sbjct: 1202 KLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSITRH 1261
Query: 3847 NNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAY 4026
NNF SF +++LFR ATGEAW +IML+C + CD DD K CG+ AY
Sbjct: 1262 NNFQSFIQGVMLLFRCATGEAWPNIMLAC--LKGKACD---DDAEKA--PGEYCGSTLAY 1314
Query: 4027 PYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIK 4206
YF+SF CSFL++NLFVAVIMDNFDYLTRD SILG HHL+EFVR+W+EYDP+A G+I
Sbjct: 1315 AYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGAHHLDEFVRIWAEYDPNATGKIH 1374
Query: 4207 HLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNL--K 4380
+ ++ +L+ + PPLGFG CP+RLA K+L+ MNMPL+ + V F TLFAL+R NL K
Sbjct: 1375 YTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSIK 1434
Query: 4381 IYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGK--EDDVTVGKFYATFLIQDYF 4554
+ +D+A+ +LR I IW K +L+ +VPP+ + + ++VGK YA FLI + +
Sbjct: 1435 MRAPEEMDQADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGFLILESW 1494
Query: 4555 RRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDEPEPQH 4734
R + G L + P + LQ R H L A +G+L ++ H
Sbjct: 1495 RSTR-------FGQLDSGMPM-LELQDASR--HPSQESLTGADAGHLHPGHSYMN---GH 1541
Query: 4735 RRPHSLFNN 4761
RR SL +N
Sbjct: 1542 RRSPSLRHN 1550
Score = 92.8 bits (229), Expect = 8e-17
Identities = 73/271 (26%), Positives = 125/271 (45%), Gaps = 21/271 (7%)
Frame = +1
Query: 2326 SSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNY 2499
+SLFIL+ N R + ++ F AVL I+ + +LA E+ L + L
Sbjct: 16 TSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEK 75
Query: 2500 FDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXX 2679
+ +F +F VE +LK++ GLV HK S+ RN +N++D VV +T F+ + +
Sbjct: 76 TEAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVV---VTGFMTQYPQIGPEV 132
Query: 2680 XXXXXXXXXXXXAINRAKG---LKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFK 2850
+ G L+ V++ +I A+ + I L+ +FAIIG++ +
Sbjct: 133 DLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYS 192
Query: 2851 G----TFFLCNDLSKM-----TEAECRGEYI------HYEDGDPTKPVSKKRVWSNNDF- 2982
G T + D +K+ +E C + I + + T +K N+
Sbjct: 193 GALHKTCYSLEDPNKLVKEGESETPCNTDNILEKATGSFVCNNTTSMCLEKWEGPNSGIT 252
Query: 2983 NFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
+FDN+G AM+++F T EGW +LY D+
Sbjct: 253 SFDNIGFAMLTVFQCITMEGWTAILYWTNDA 283
>gi|24641459|ref|NP_511133.2| CG1522-PA [Drosophila melanogaster]
gi|17380458|sp|P91645|CCAA_DROME Voltage-dependent calcium channel
type A alpha-1 subunit (Cacophony protein) (Nightblind A
protein) (No-on-transient B protein) (DmCA1A)
gi|22832123|gb|AAF48120.2| CG1522-PA [Drosophila melanogaster]
Length = 1848
Score = 1130 bits (2924), Expect = 0.0
Identities = 663/1569 (42%), Positives = 881/1569 (55%), Gaps = 55/1569 (3%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+NPIRK I+EW PFE+ +L I ANC+ LA+ + P D LE E F+ +
Sbjct: 24 DNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFLCI 83
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F +E LKI+A+G + H +YLRN WNI+DF +VV G + T ++ + D++ LRA R
Sbjct: 84 FCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFM-TQYPQIGPE-VDLRTLRAIR 141
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI- 756
VLRPL+LVSG+PSLQVVL +I++AM PLL I LLVLF I+I+AIIGLE + G LH TC
Sbjct: 142 VLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYS 201
Query: 757 --DPATGQLAQKDPTPCGTDT----EGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGI 918
DP + TPC TD +F C + S+ C W GPN+GI
Sbjct: 202 LEDPNKLVKEGESETPCNTDNILEKATGSFVCNNTTSM--------CLEK--WEGPNSGI 251
Query: 919 TNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGV 1098
T+FDN G AMLTVFQC+++EGWT ++YW NDA+G + WIYFV L+++GSFF+LNLVLGV
Sbjct: 252 TSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGV 311
Query: 1099 LSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPV--- 1269
LSGEFS ER + R FQK R + + + YLDWITQAE++ E E+E +
Sbjct: 312 LSGEFSNERNRVERRMEFQKCRFRAMFQTAMVSYLDWITQAEEVILAEERTTEEEKMHIM 371
Query: 1270 -----------------------AQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNX 1380
+ P R EK
Sbjct: 372 EARRRNAAKRKKLKSLGKSKSTDTEEEEAEEDYGDDGYLKTRSKPQGSCTGFWRAEK--- 428
Query: 1381 XXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEM 1560
VK+Q FYW EHYGQ +L F A F+ LF EM
Sbjct: 429 RFRFWIRHTVKTQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEM 488
Query: 1561 LLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMK--PLGVSVLRSARLLRIFK 1734
+KMY+LG Y S FNRFDC V+ SI E V + +K G+SVLR+ RLLRIFK
Sbjct: 489 FIKMYALGPRIYFESSFNRFDCVVISGSIFE---VIWSEVKGGSFGLSVLRALRLLRIFK 545
Query: 1735 VTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRAN 1914
VTKYW+ GMQ+FGG+FN P+ N
Sbjct: 546 VTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNLPGGTPE--TN 603
Query: 1915 FDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVF 2094
F+TF ALLTVFQILTGEDWN VMY GI S GG G+I IY+IVL + GNY LLNVF
Sbjct: 604 FNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQK-GMIYSIYFIVLVLFGNYTLLNVF 662
Query: 2095 LAIAVDNLADADSLTNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSARPR 2274
LAIAVDNLA+A LT A + ++ +
Sbjct: 663 LAIAVDNLANAQELTAAEEEQVEEDKEKQLQELEKEMEALQADGVHVENGDGAVAPSKSK 722
Query: 2275 -------RMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVS 2433
+ E KP+ SS+FILS TN R + VVN YF ++ I +S
Sbjct: 723 GKKKEEEKKEEEEVTEGPKPMLPYSSMFILSPTNPIRRGAHWVVNLPYFDFFIMVVISMS 782
Query: 2434 SAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLD 2613
S LAAEDP++ NS RN ILNYFDY FT VFT+E+ LK++ G++ H GS+ R +N++D
Sbjct: 783 SIALAAEDPVRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMD 842
Query: 2614 ILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXA------INRAKGLKHVVQCVIVAVK 2775
+VV + SF S I R LK V CV+ ++K
Sbjct: 843 AVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLK 902
Query: 2776 TIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSK 2955
+ NI++V + QF+F++IGVQLF G FF C D SK T AEC+G Y YE+ D P +
Sbjct: 903 NVVNILIVYILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFKYEE-DELLPKQE 961
Query: 2956 KRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXX 3135
RVW F++DNV AM++LF V T EGWPQ+L ++ + ED+GPI N R +++
Sbjct: 962 LRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYI 1021
Query: 3136 XXXXXXXXXXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR 3315
+I+TFQ +GE E ++ E+DKNQ+ CI+F + A+P RY+P+NR
Sbjct: 1022 VYFIVFPFFFVNIFVALIIITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNR 1081
Query: 3316 --LQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFE 3489
+Y+VW V S FEY I ++IV NT+ L K++ +E L N+ FTG+F+ E
Sbjct: 1082 NTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVE 1141
Query: 3490 AVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLV 3669
VLKI+ KN+ D WN+FDL+ V+GS +D + + G+N I++ F RLFR RL+
Sbjct: 1142 TVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDALWMEF---GSNSINVGFLRLFRAARLI 1198
Query: 3670 KLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDD-STSIHRN 3846
KLL +G IR LLWTF++SF+ALPYV LLI +LFFIYA+IGMQ FG + L SI R+
Sbjct: 1199 KLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSITRH 1258
Query: 3847 NNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAY 4026
NNF SF +++LFR ATGEAW +IML+C + CD DD K CG+ AY
Sbjct: 1259 NNFQSFIQGVMLLFRCATGEAWPNIMLACLKGK--ACD---DDAEKAP--GEYCGSTLAY 1311
Query: 4027 PYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIK 4206
YF+SF CSFL++NLFVAVIMDNFDYLTRD SILG HHL+EFVR+W+EYDP+A G+I
Sbjct: 1312 AYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGAHHLDEFVRIWAEYDPNATGKIH 1371
Query: 4207 HLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNL--K 4380
+ ++ +L+ + PPLGFG CP+RLA K+L+ MNMPL+ + V F TLFAL+R NL K
Sbjct: 1372 YTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSIK 1431
Query: 4381 IYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGK--EDDVTVGKFYATFLIQDYF 4554
+ +D+A+ +LR I IW K +L+ +VPP+ + + ++VGK YA FLI + +
Sbjct: 1432 MRAPEEMDQADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGFLILESW 1491
Query: 4555 RRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDEPEPQH 4734
R + G L + P + LQ R H L A +G+L ++ H
Sbjct: 1492 RSTR-------FGQLDSGMPM-LELQDASR--HPSQESLTGADAGHLHPGHSYMN---GH 1538
Query: 4735 RRPHSLFNN 4761
RR SL +N
Sbjct: 1539 RRSPSLRHN 1547
Score = 92.8 bits (229), Expect = 8e-17
Identities = 73/271 (26%), Positives = 125/271 (45%), Gaps = 21/271 (7%)
Frame = +1
Query: 2326 SSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNY 2499
+SLFIL+ N R + ++ F AVL I+ + +LA E+ L + L
Sbjct: 16 TSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEK 75
Query: 2500 FDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXX 2679
+ +F +F VE +LK++ GLV HK S+ RN +N++D VV +T F+ + +
Sbjct: 76 TEAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVV---VTGFMTQYPQIGPEV 132
Query: 2680 XXXXXXXXXXXXAINRAKG---LKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFK 2850
+ G L+ V++ +I A+ + I L+ +FAIIG++ +
Sbjct: 133 DLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYS 192
Query: 2851 G----TFFLCNDLSKM-----TEAECRGEYI------HYEDGDPTKPVSKKRVWSNNDF- 2982
G T + D +K+ +E C + I + + T +K N+
Sbjct: 193 GALHKTCYSLEDPNKLVKEGESETPCNTDNILEKATGSFVCNNTTSMCLEKWEGPNSGIT 252
Query: 2983 NFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
+FDN+G AM+++F T EGW +LY D+
Sbjct: 253 SFDNIGFAMLTVFQCITMEGWTAILYWTNDA 283
>gi|31206785|ref|XP_312359.1| ENSANGP00000012084 [Anopheles gambiae]
gi|21295904|gb|EAA08049.1| ENSANGP00000012084 [Anopheles gambiae str.
PEST]
Length = 1800
Score = 1126 bits (2912), Expect = 0.0
Identities = 641/1482 (43%), Positives = 849/1482 (57%), Gaps = 43/1482 (2%)
Frame = +1
Query: 250 IVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIV 429
I+EW PFE+ +L I ANC+ LA+ + P D LE E F+ +F +E LKI+
Sbjct: 5 IIEWPPFEYAVLLTIIANCVVLALEEHLPHGDKTILAQKLEKTEAYFLGIFCVEASLKIL 64
Query: 430 AMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSG 609
A+GF+ H +YLRN WNI+DF +VV G ++ K D++ LRA RVLRPL+LVSG
Sbjct: 65 ALGFVMHKHSYLRNIWNIMDFFVVVTGFITLFPQKGP--EVDLRTLRAIRVLRPLKLVSG 122
Query: 610 VPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKD 789
+PSLQVVL +I++AM PLL I LLVLF I+I+AIIGLE + G LH +C + +
Sbjct: 123 IPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHRSCY--SLEDIYNDT 180
Query: 790 PTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCV 969
P G A+ C SDS C W GPN GIT+FDN G AMLTVFQC+
Sbjct: 181 IAPTG------AYVCNSSDST--------CIEQ--WEGPNFGITSFDNIGFAMLTVFQCI 224
Query: 970 SLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGL 1149
++EGWT ++YW NDA+G + WIYFV L++LGSFF+LNLVLGVLSGEF+KEREK R
Sbjct: 225 TMEGWTAILYWTNDALGSTFNWIYFVPLIVLGSFFMLNLVLGVLSGEFAKEREKVENRQE 284
Query: 1150 FQKFREKQQLEEDLKGYLDWITQAED------IEPVNEDEQEDEPVAQTXXXXXXXXXXX 1311
F K R +QQLE++L GY++WI +A D + + +E P +++
Sbjct: 285 FLKLRRQQQLEKELNGYVEWICKAGDGSGRASVCVLLFSAREKLPESESMTLRKRERERE 344
Query: 1312 XXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQ 1491
W + K + VK+Q FYW EHYGQ
Sbjct: 345 HFT-------WQRKCKGFWRAEKRFRFWIRHTVKTQWFYWFVIVLVFFNTVCVAVEHYGQ 397
Query: 1492 SEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYF 1671
WL F A F+ LF MEM +KMY+LG Y S FNRFDC V+ SI E V +
Sbjct: 398 PNWLTQFLYYAEYVFLGLFMMEMWIKMYALGPRIYFESSFNRFDCVVISGSIFEVV---W 454
Query: 1672 DLMK--PLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1845
+K G+SVLR+ RLLRIFKVTKYW+
Sbjct: 455 SEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFA 514
Query: 1846 XXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTL 2025
GMQ+FGG+FN P NF+TF ALLTVFQILTGEDWN VMY GIES GG
Sbjct: 515 LLGMQLFGGQFNL--PDGTPPTNFNTFPIALLTVFQILTGEDWNEVMYQGIESQGG-HKK 571
Query: 2026 GVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNAXXXXXXXXXXXXXXXXXXXX 2205
G+I +Y+I+L + GNY LLNVFLAIAVDNLA+A LT A
Sbjct: 572 GMIYSLYFIILVLFGNYTLLNVFLAIAVDNLANAQELT-AAEEEQLEENKEKQQMELDKE 630
Query: 2206 XXXXXXXXXXXXXXXXMTSARPRRMS--------------------EVPAASTVKPIPKA 2325
++S P R + E+P KP+
Sbjct: 631 MEALHMQNDGSPPRVEVSSPSPTRGNGSGGSTKSKKKDEEKEEDDDEIPDGP--KPMLPY 688
Query: 2326 SSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMILNYFD 2505
SS+F+LS TN R + VVN YF ++ I +SS LAAEDP++ +S RN ILN+FD
Sbjct: 689 SSMFVLSPTNPIRCGAHWVVNLRYFDFFIMVVISLSSIALAAEDPVEEDSPRNKILNFFD 748
Query: 2506 YFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXXX 2685
Y FT VFT+E+ LK++ G++ H GS+ R +N++D +VV + SF S
Sbjct: 749 YAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNVMDAVVVICAAVSFGFDMTGSSAGQNL 808
Query: 2686 XXXXXXXXXXA------INRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
I R LK V CV+ ++K + NI++V + QF+FA+I VQLF
Sbjct: 809 STIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVINILIVYILFQFIFAVIAVQLF 868
Query: 2848 KGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVV 3027
G FF C D SK T EC+G + Y DG P + R W F++DNV AM++LF V
Sbjct: 869 NGKFFYCTDDSKHTSEECKGHFFVY-DGADQLPRREPREWKTQSFHYDNVATAMLTLFAV 927
Query: 3028 STFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIVTFQN 3207
T EGWPQ+L ++ + EDKGPI N R +++ +I+TFQ
Sbjct: 928 QTGEGWPQVLQNSMAATYEDKGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIITFQE 987
Query: 3208 EGEREYENCELDKNQRKCIEFALKAKPHRRYIP--RNRLQYRVWWFVTSRAFEYVIFLII 3381
+GE E ++ E+DKNQ+ CI+F + A+P RY+P RN +Y+VW V S FEY I ++I
Sbjct: 988 QGEAELQDGEIDKNQKSCIDFTIGARPLERYMPNKRNSFKYKVWRIVVSTPFEYFIMMLI 1047
Query: 3382 VMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLL 3561
V NT+ L K + + D L NL+FT F E ++K++A KN+ D WN+FD +
Sbjct: 1048 VFNTLLLMMKFHDAPTTLIDILSFMNLVFTFFFLLETIMKLIAYGCKNFFKDPWNIFDFI 1107
Query: 3562 VVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALP 3741
V+GS ID +L G N ++ F RLFR RL+KLL +G IR LLWTF++SF+ALP
Sbjct: 1108 TVIGSIIDALVLEL---GENSFNVGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALP 1164
Query: 3742 YVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDI 3921
YV LLI +LFFIYA+IGMQ FG + LD +SI R+NNF SF +++LFR ATGE+W +I
Sbjct: 1165 YVCLLIAMLFFIYAIIGMQVFGNIELDPESSITRHNNFRSFVQGLMLLFRCATGESWPNI 1224
Query: 3922 MLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDN 4101
ML+C CDP ++ ++ CG+ AY YF+SF CSFL++NLFVAVIMDN
Sbjct: 1225 MLACLKGRP--CDPRANKPNE------TCGSTLAYAYFVSFIFFCSFLMLNLFVAVIMDN 1276
Query: 4102 FDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRL 4281
FDYLTRD SILG HHL+EFVR+W+EYDP+A G+I + ++ +L+ + PPLGFG CP+RL
Sbjct: 1277 FDYLTRDSSILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRL 1336
Query: 4282 ACKRLVSMNMPLNSDGTVCFNATLFALVRTNL--KIYTEGNIDEANEQLRSAIKRIWKRT 4455
A K+L+ MNMPL+++G V F TLFAL+R NL K+ T +D+A+ +LR I IW
Sbjct: 1337 AYKKLIRMNMPLDAEGKVAFTTTLFALIRENLNIKMRTAEEMDQADAELRHTISHIWPLQ 1396
Query: 4456 HKDLLDEVVP-----PAGKEDDVTVGKFYATFLIQDYFRRFK 4566
K +LD +VP AGK +TVGK YA LI + +R K
Sbjct: 1397 AKKMLDLLVPLNEELNAGK---LTVGKIYAGLLILESWRNTK 1435
Score = 154 bits (390), Expect = 2e-35
Identities = 155/663 (23%), Positives = 265/663 (39%), Gaps = 32/663 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR +V + F+F I+ +I + IALA P ++ +N +L +Y F VF
Sbjct: 698 NPIRCGAHWVVNLRYFDFFIMVVISLSSIALAAEDP--VEEDSPRNKILNFFDYAFTGVF 755
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD--------- 555
TIE +LKIV +G + HP +YLR WN++D ++V+ VS GFD
Sbjct: 756 TIEMLLKIVDLGVILHPGSYLREFWNVMDAVVVICAAVSF--------GFDMTGSSAGQN 807
Query: 556 ---VKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLEL 726
+K+LR RVLRPL+ + VP L+ V + ++ ++ +++I ++ + I+A+I ++L
Sbjct: 808 LSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVINILIVYILFQFIFAVIAVQL 867
Query: 727 FCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVR-WECSSNTTWPG 903
F GK C D D + +G F +D L R W+ S
Sbjct: 868 FNGKFF-YCTD---------DSKHTSEECKGHFFVYDGADQLPRREPREWKTQS------ 911
Query: 904 PNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAV---------GREWPWIYFVTLV 1056
++DN AMLT+F + EGW V+ A R I+++
Sbjct: 912 -----FHYDNVATAMLTLFAVQTGEGWPQVLQNSMAATYEDKGPIQNFRIEMSIFYIVYF 966
Query: 1057 ILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEP 1236
I+ FF +N+ + ++ F ++ E G +++++ K +D+ A +E
Sbjct: 967 IVFPFFFVNIFVALIIITFQEQGEAELQDG---------EIDKNQKSCIDFTIGARPLER 1017
Query: 1237 VNEDEQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKS 1416
+ K N +V +
Sbjct: 1018 YMPN----------------------------------------KRNSFKYKVWRIVVST 1037
Query: 1417 QTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTY 1596
Y+ H + +D M +F F +E ++K+ + G +
Sbjct: 1038 PFEYFIMMLIVFNTLLLMMKFHDAPTTLIDILSFMNLVF-TFFFLLETIMKLIAYGCKNF 1096
Query: 1597 TTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXX 1776
+N FD VI SI++ +++ V LR R R+ K+ +
Sbjct: 1097 FKDPWNIFDFITVIGSIIDALVLELG-ENSFNVGFLRLFRAARLIKLLRQGYTIRILLWT 1155
Query: 1777 XXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPR-ANFDTFVQALLTVFQ 1953
GMQVF G +P+ R NF +FVQ L+ +F+
Sbjct: 1156 FVQSFKALPYVCLLIAMLFFIYAIIGMQVF-GNIELDPESSITRHNNFRSFVQGLMLLFR 1214
Query: 1954 ILTGEDWNTVMYHGIE-------SFGGVGTLGVIVCIYYIV--LFICGNYILLNVFLAIA 2106
TGE W +M ++ + T G + Y V +F C ++++LN+F+A+
Sbjct: 1215 CATGESWPNIMLACLKGRPCDPRANKPNETCGSTLAYAYFVSFIFFC-SFLMLNLFVAVI 1273
Query: 2107 VDN 2115
+DN
Sbjct: 1274 MDN 1276
Score = 79.7 bits (195), Expect = 7e-13
Identities = 59/245 (24%), Positives = 104/245 (42%), Gaps = 9/245 (3%)
Frame = +1
Query: 2368 FCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYFDYFFTSVFTVEIT 2541
+ ++ F AVL I+ + +LA E+ L + L + +F +F VE +
Sbjct: 1 YTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPHGDKTILAQKLEKTEAYFLGIFCVEAS 60
Query: 2542 LKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAI 2721
LK++ G V HK S+ RN +N++D VV + + +
Sbjct: 61 LKILALGFVMHKHSYLRNIWNIMDFFVVVTGFITLFPQKGPEVDLRTLRAIRVLRPLKLV 120
Query: 2722 NRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTF----FLCNDLSKMT 2889
+ L+ V++ +I A+ + I L+ +FAIIG++ + G + D+ T
Sbjct: 121 SGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHRSCYSLEDIYNDT 180
Query: 2890 EAECRGEYIHYEDGDPTKPVSKKRVWSNNDF---NFDNVGDAMISLFVVSTFEGWPQLLY 3060
A + D + W +F +FDN+G AM+++F T EGW +LY
Sbjct: 181 IAPTGAYVCNSSDSTCIEQ------WEGPNFGITSFDNIGFAMLTVFQCITMEGWTAILY 234
Query: 3061 VAIDS 3075
D+
Sbjct: 235 WTNDA 239
>gi|7511817|pir||T13980 calcium channel alpha-1 chain - fruit fly
(Drosophila melanogaster)
gi|1737064|gb|AAC47406.1| calcium channel alpha-1 subunit
Length = 1851
Score = 1123 bits (2905), Expect = 0.0
Identities = 659/1569 (42%), Positives = 878/1569 (55%), Gaps = 55/1569 (3%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+NPIRK I+EW PFE+ +L I ANC+ LA+ + P D LE E F+ +
Sbjct: 24 DNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFLCI 83
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F +E LKI+A+G + H +YLRN WNI+DF +VV G + T ++ + D++ LRA R
Sbjct: 84 FCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFM-TQYPQIGPE-VDLRTLRAIR 141
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI- 756
VLRPL+LVSG+PSLQVVL +I++AM PLL I LLVLF I+I+AIIGLE + G LH TC
Sbjct: 142 VLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYS 201
Query: 757 --DPATGQLAQKDPTPCGTDT----EGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGI 918
DP + TPC TD +F C + S+ C W GPN+GI
Sbjct: 202 LEDPNKLVKEGESETPCNTDNILEKATGSFVCNNTTSM--------CLEK--WEGPNSGI 251
Query: 919 TNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGV 1098
T+FDN G AMLTVFQC+++EGWT ++YW NDA+G + WIYFV L+++GSFF+LNLVLGV
Sbjct: 252 TSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGV 311
Query: 1099 LSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPV--- 1269
LSGEFS ER + R FQK R + + + YLDWITQAE++ E E+E +
Sbjct: 312 LSGEFSNERNRVERRMEFQKCRFRAMFQTAMVSYLDWITQAEEVILAEERTTEEEKMHIM 371
Query: 1270 -----------------------AQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNX 1380
+ P R EK
Sbjct: 372 EARRRNAAKRKKLKSLGKSKSTDTEEEEAEEDYGDDGYLKTRSKPQGSCTGFWRAEK--- 428
Query: 1381 XXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEM 1560
VK+Q FYW EHYGQ +L F A F+ LF EM
Sbjct: 429 RFRFWIRHTVKTQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEM 488
Query: 1561 LLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMK--PLGVSVLRSARLLRIFK 1734
+KMY+LG Y S FNRFDC V+ SI E V + +K G+SVLR+ RLLRIFK
Sbjct: 489 FIKMYALGPRIYFESSFNRFDCVVIGGSIFE---VIWSEVKGGSFGLSVLRALRLLRIFK 545
Query: 1735 VTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRAN 1914
VTKYW+ GMQ+FGG+FN P+ N
Sbjct: 546 VTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNLPGGTPE--TN 603
Query: 1915 FDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVF 2094
F+TF ALLTVFQILTGEDWN VMY GI S GG G+I IY+IVL + GNY LLNVF
Sbjct: 604 FNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQK-GMIYSIYFIVLVLFGNYTLLNVF 662
Query: 2095 LAIAVDNLADADSLTNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSARPR 2274
LAIAVDNLA+A LT A + ++ +
Sbjct: 663 LAIAVDNLANAQELTAAEEEQVEEDKEKQLQELEKEMEALQADGVHVENGDGAVAPSKSK 722
Query: 2275 -------RMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVS 2433
+ E KP+ SS+FILS TN R + VVN YF ++ I +S
Sbjct: 723 GKKKEEEKKEEEEVTEGPKPMLPYSSMFILSPTNPIRRGAHWVVNLPYFDFFIMVVISMS 782
Query: 2434 SAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLD 2613
S LAAEDP++ NS RN ILNYFDY FT VFT+E+ LK++ G++ H GS+ R ++++D
Sbjct: 783 SIALAAEDPVRENSRRNKILNYFDYAFTGVFTMEMLLKIVDLGVILHPGSYLREFWSIMD 842
Query: 2614 ILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXA------INRAKGLKHVVQCVIVAVK 2775
+VV + SF S I R LK V CV+ ++K
Sbjct: 843 AVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLK 902
Query: 2776 TIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSK 2955
+ +I++V + QF+F++IGVQLF G FF C D K T AEC+G Y YE+ D P +
Sbjct: 903 NVVSILIVYILFQFIFSVIGVQLFNGKFFYCTDEGKHTSAECQGSYFKYEE-DELLPKQE 961
Query: 2956 KRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXX 3135
RVW F++DNV AM++LF V T EGWPQ+L ++ + ED+GPI N R V++
Sbjct: 962 LRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEVSIFYI 1021
Query: 3136 XXXXXXXXXXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR 3315
+I+TFQ +GE E ++ E+DKNQ+ CI+F + A+P RY+P+NR
Sbjct: 1022 VYFIVFPFFFVNIFVALIIITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNR 1081
Query: 3316 --LQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFE 3489
+Y+VW V S FEY I ++IV NT+ L K++ +E L N+ FTG+F+ E
Sbjct: 1082 NTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVE 1141
Query: 3490 AVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLV 3669
VLKI+ KN+ D WN+FDL+ V+GS +D + + ++ I++ F RLFR RL+
Sbjct: 1142 TVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDALWMEFGHDDSSSINVGFLRLFRAARLI 1201
Query: 3670 KLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDD-STSIHRN 3846
KLL +G IR LLWTF++SF+ALPYV LLI +LFFIYA+IGMQ FG + L SI R+
Sbjct: 1202 KLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSITRH 1261
Query: 3847 NNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAY 4026
NNF SF +++LFR ATGEAW +IML+C + CD DD K CG+ AY
Sbjct: 1262 NNFQSFIHGVMLLFRCATGEAWPNIMLAC--LKGKACD---DDAEKA--PGEYCGSTLAY 1314
Query: 4027 PYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIK 4206
YF+SF CSFL++NLFVAVIMDNFDYLTRD SILG HHL+EFVR+W+EYDP A G+I
Sbjct: 1315 AYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGAHHLDEFVRIWAEYDPGATGKIH 1374
Query: 4207 HLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNL--K 4380
+ ++ +L+ + PPLGFG CP+RLA K+L+ MNMPL+ + V F TLFAL+R NL K
Sbjct: 1375 YTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSIK 1434
Query: 4381 IYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGK--EDDVTVGKFYATFLIQDYF 4554
+ +D+A+ +LR I IW K +L+ +VPP+ + + ++VGK YA FLI + +
Sbjct: 1435 MRAPEEMDQADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGFLILESW 1494
Query: 4555 RRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDEPEPQH 4734
R + G L + P + LQ R H L A +G+L ++ H
Sbjct: 1495 RSTR-------FGQLDSGMPM-LELQDASR--HPSQESLTGADAGHLHPGHSYMN---GH 1541
Query: 4735 RRPHSLFNN 4761
RR SL +N
Sbjct: 1542 RRSPSLRHN 1550
Score = 92.8 bits (229), Expect = 8e-17
Identities = 73/271 (26%), Positives = 125/271 (45%), Gaps = 21/271 (7%)
Frame = +1
Query: 2326 SSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNY 2499
+SLFIL+ N R + ++ F AVL I+ + +LA E+ L + L
Sbjct: 16 TSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEK 75
Query: 2500 FDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXX 2679
+ +F +F VE +LK++ GLV HK S+ RN +N++D VV +T F+ + +
Sbjct: 76 TEAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVV---VTGFMTQYPQIGPEV 132
Query: 2680 XXXXXXXXXXXXAINRAKG---LKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFK 2850
+ G L+ V++ +I A+ + I L+ +FAIIG++ +
Sbjct: 133 DLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYS 192
Query: 2851 G----TFFLCNDLSKM-----TEAECRGEYI------HYEDGDPTKPVSKKRVWSNNDF- 2982
G T + D +K+ +E C + I + + T +K N+
Sbjct: 193 GALHKTCYSLEDPNKLVKEGESETPCNTDNILEKATGSFVCNNTTSMCLEKWEGPNSGIT 252
Query: 2983 NFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
+FDN+G AM+++F T EGW +LY D+
Sbjct: 253 SFDNIGFAMLTVFQCITMEGWTAILYWTNDA 283
>gi|30059171|gb|AAP13107.1| high voltage activated calcium channel
alpha-1 subunit [Caenorhabditis elegans]
gi|32699210|gb|AAP82640.2| Uncoordinated protein 2, isoform b
[Caenorhabditis elegans]
Length = 2027
Score = 1120 bits (2898), Expect = 0.0
Identities = 680/1727 (39%), Positives = 927/1727 (53%), Gaps = 99/1727 (5%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N IR+ +I+EW PFE+ IL I NC+ L++ Q P D + LE E F+ +
Sbjct: 94 DNIIRRNAKAIIEWGPFEYFILLTIIGNCVVLSMEQHLPKNDKKALSEWLERTEPYFMGI 153
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVS-------TILSKMSIQGFDV 558
F +ECVLK++A GF H +YLR+ WNI+DFI+VV G+V+ T + + D+
Sbjct: 154 FCLECVLKVIAFGFALHKGSYLRSGWNIMDFIVVVSGVVTMLPFSPATQTANQPVDSVDL 213
Query: 559 KALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGK 738
+ LRA RVLRPL+LVSG+PSLQVVL +IL AM PLL I LLVLF I+I+AIIGLE + G
Sbjct: 214 RTLRAVRVLRPLKLVSGIPSLQVVLKSILCAMAPLLQIGLLVLFAIIIFAIIGLEFYSGA 273
Query: 739 LHSTCIDPATGQL--AQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTT-----W 897
HS C + G++ + P PC T + MGV + C T W
Sbjct: 274 FHSACYNER-GEIENVSERPMPCTNKT-------------SPMGV-YNCDVKGTTCLQKW 318
Query: 898 PGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFV 1077
GPN GIT+FDN G AM+TVFQC+++EGWT VMY+ ND++G + W YF+ L++LGSFF+
Sbjct: 319 IGPNYGITSFDNIGFAMITVFQCITMEGWTTVMYYTNDSLGSTYNWAYFIPLIVLGSFFM 378
Query: 1078 LNLVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQE 1257
LNLVLGVLSGEF+KERE+ R F K R +QQ+E +L GYL+WI AE++ + ED
Sbjct: 379 LNLVLGVLSGEFAKERERVENRREFLKLRRQQQIERELNGYLEWILTAEEVI-LKEDRTT 437
Query: 1258 DEPVAQTXXXXXXXXXXXXXXXXXXPS---------------------------KWAARM 1356
+E A S ++A R
Sbjct: 438 EEEKAAIMEARRRAANKKLKQASKQQSTETEEDFEEDEDEMEEEYVDEGGTVEDEFAERK 497
Query: 1357 KR-----LEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTM 1521
KR + K +VK+Q FYW SEHYGQ +W F
Sbjct: 498 KRGCCHSVGKFIKQLRIQIRIMVKTQIFYWSVITLVFLNTCCVASEHYGQPQWFTDFLKY 557
Query: 1522 ANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVL--VYFDLMKPLGV 1695
A F+ +F +EMLLK++++G TY S+FNRFDC V++ S E + VY G+
Sbjct: 558 AEFVFLGIFVVEMLLKLFAMGSRTYFASKFNRFDCVVIVGSAAEVIWAEVYGG---SFGI 614
Query: 1696 SVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGK 1875
SV+R+ RLLRIFK+T YW GMQ+FGG+
Sbjct: 615 SVMRALRLLRIFKLTSYWVSLRNLVRSLMNSMRSIISLLFLLFLFILIFALLGMQLFGGR 674
Query: 1876 FNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIV 2055
FNF P +FDTF AL+TVFQILTGEDWN VMY IES GG+ + G IY+IV
Sbjct: 675 FNFPTMHPY--THFDTFPVALITVFQILTGEDWNEVMYLAIESQGGIYSGGWPYSIYFIV 732
Query: 2056 LFICGNYILLNVFLAIAVDNLADADSLTNAXXXXXXXXXXXXXXXXXX---------XXX 2208
L + GNY LLNVFLAIAVDNLA+A LT A
Sbjct: 733 LVLFGNYTLLNVFLAIAVDNLANAQELTAAEEADEKANEIEEESEELDEQYQEGDHCTID 792
Query: 2209 XXXXXXXXXXXXXXXMTSARPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVN 2388
M E KP+ SS+F LS TN FRV + +V
Sbjct: 793 MEGKTAGDMCAVARAMDDLDEECEEEESPFGGPKPMVPYSSMFFLSPTNPFRVLIHSIVC 852
Query: 2389 HSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLV 2568
YF V+ I +SS LAAEDP+ + RN +L Y DY FT VF E+ LK+I G++
Sbjct: 853 TKYFEMMVMTVICLSSVSLAAEDPVDEENPRNKVLQYMDYCFTGVFACEMLLKLIDQGIL 912
Query: 2569 FHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXA------INRA 2730
H GS+CR+ +N+LD +VV +L +F S I R
Sbjct: 913 LHPGSYCRDFWNILDGIVVTCALFAFGFAGTEGSAGKNLNTIKSLRVLRVLRPLKTIKRI 972
Query: 2731 KGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGE 2910
LK V CV+ ++K + NI++V F+ QF+FA+I VQLF G FF C D ++ C G+
Sbjct: 973 PKLKAVFDCVVNSLKNVFNILIVYFLFQFIFAVIAVQLFNGKFFFCTDKNRKFANTCHGQ 1032
Query: 2911 YIHYED-GDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEED 3087
+ Y++ DP P ++R W FN+DN +AM++LFVV+T EGWP + ++D+ ED
Sbjct: 1033 FFVYDNQNDP--PRVEQREWRLRPFNYDNTINAMLTLFVVTTGEGWPGIRQNSMDTTFED 1090
Query: 3088 KGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIE 3267
+GP R VAL +I+TFQ +GE E +LDKNQ++CI+
Sbjct: 1091 QGPSPFFRVEVALFYVMFFIVFPFFFVNIFVALIIITFQEQGEAELSEGDLDKNQKQCID 1150
Query: 3268 FALKAKPHRRYIP--RNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFED 3441
FAL A+P ++P +N +YR+W VTS FEY I +I NT+ L K+Y + +E+
Sbjct: 1151 FALNARPRSLFMPEDKNSTKYRIWRLVTSPPFEYFIMTMICCNTLILMMKYYNNPLFYEE 1210
Query: 3442 FLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTN 3621
L +FN T VF E++LKI+A +NY D WN FD + VVGS D + G +
Sbjct: 1211 ILRLFNTALTAVFTVESILKILAFGVRNYFRDGWNRFDFVTVVGSITDALVTEF---GGH 1267
Query: 3622 LISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQF 3801
+S+ F RLFR RL++LL +G IR LLWTF++SF+ALPYV LLI +LFFIYA++GMQ
Sbjct: 1268 FVSLGFLRLFRAARLIRLLQQGYTIRILLWTFVQSFKALPYVCLLIGMLFFIYAIVGMQV 1327
Query: 3802 FGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDRED-VRCDPMSDDY 3978
FG + L+ +T I+R+NNF SF A+++LFR ATGE WQDIM++ +D R ++
Sbjct: 1328 FGNIWLNAATEINRHNNFQSFFNAVILLFRCATGEGWQDIMMAAVQGKDCARAGSAEINF 1387
Query: 3979 HKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEF 4158
KG CG+N +Y YF SF L SFL++NLFVAVIMDNFDYLTRD SILGPHHL+EF
Sbjct: 1388 EKG----QTCGSNVSYAYFTSFVFLSSFLMLNLFVAVIMDNFDYLTRDSSILGPHHLDEF 1443
Query: 4159 VRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVC 4338
+R+W++YDP A GRI + ++ +LR ++PP+GFGK CP+RLA K L+ MNMP+ DGTV
Sbjct: 1444 IRVWADYDPAATGRIHYSEMYEMLRIMAPPVGFGKKCPYRLAYKHLIRMNMPVAEDGTVH 1503
Query: 4339 FNATLFALVRTNL--KIYTEGNIDEANEQLRSAIKRIWK-RTHKDLLDEVVPPAGK--ED 4503
F TLFAL+R +L K+ +DEA+E+LR +K+IW + K+++D VVPP +
Sbjct: 1504 FTTTLFALIRESLSIKMRPVEEMDEADEELRLTLKKIWPLKAKKNMVDLVVPPNHELCFQ 1563
Query: 4504 DVTVGKFYATFLIQDYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHE--------- 4656
+TVGK YA LI + +R K E+ +G+ +A + H
Sbjct: 1564 KLTVGKIYAGLLILENYRARKSGTEVGGQGLFGGGLRSLVAAAKAAESQHSSHTPQPPEE 1623
Query: 4657 ---IGPELKRAISGNLETDFNFDEPEPQ------HRRPHSLFNNLVHRLSGA---GSKSP 4800
I P+ + S + Q +RP+SLFN+ V + G +
Sbjct: 1624 TTPIIPQHAQQFSAAPTMSAQGSLQQMQGTSSGGGQRPYSLFNSFVDTIKSGKQDGDVTD 1683
Query: 4801 TEHERIEKGSTLLPFQPRSFSPTHS--LAGAEGSPVPSQM-HRGAPINQSINLPPVNGSA 4971
+++ +++ + R S S G P Q H A N+S + P A
Sbjct: 1684 VQYQSVDQQHEKMNSTGRRLSDMFSKIRRGTSADHNPHQTEHLLAQDNRSPSSPRYRSMA 1743
Query: 4972 RRLPALPPYANHIHDETDDGPRYR---DTGDRAGYDQSSRMVVANRN 5103
R P P + PRYR R+ Y S R + RN
Sbjct: 1744 RASPPSPA------ERYGHPPRYRTESPPSSRSEYQMSIRDPIIRRN 1784
Score = 87.0 bits (214), Expect = 5e-15
Identities = 69/275 (25%), Positives = 122/275 (44%), Gaps = 25/275 (9%)
Frame = +1
Query: 2326 SSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNY 2499
SSLFI + N R ++ F +L I+ + +L+ E L N + + L
Sbjct: 86 SSLFIFAEDNIIRRNAKAIIEWGPFEYFILLTIIGNCVVLSMEQHLPKNDKKALSEWLER 145
Query: 2500 FDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXX 2679
+ +F +F +E LKVI FG HKGS+ R+ +N++D +VV + + + + A
Sbjct: 146 TEPYFMGIFCLECVLKVIAFGFALHKGSYLRSGWNIMDFIVVVSGVVTMLPFSPATQTAN 205
Query: 2680 XXXXXXXXXXXXAINRAKGLK---------HVVQCVIVAVKTIGNIMLVTFMLQFMFAII 2832
A+ + LK V++ ++ A+ + I L+ +FAII
Sbjct: 206 QPVDSVDLRTLRAVRVLRPLKLVSGIPSLQVVLKSILCAMAPLLQIGLLVLFAIIIFAII 265
Query: 2833 GVQLFKGTFFLC-----NDLSKMTE--AECRGEY----IHYEDGDPTKPVSKKRVWSNND 2979
G++ + G F ++ ++E C + ++ D T + K W +
Sbjct: 266 GLEFYSGAFHSACYNERGEIENVSERPMPCTNKTSPMGVYNCDVKGTTCLQK---WIGPN 322
Query: 2980 F---NFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
+ +FDN+G AMI++F T EGW ++Y DS
Sbjct: 323 YGITSFDNIGFAMITVFQCITMEGWTTVMYYTNDS 357
>gi|457927|gb|AAA81883.1| calcium channel alpha-1 subunit
Length = 2516
Score = 1112 bits (2875), Expect = 0.0
Identities = 560/858 (65%), Positives = 657/858 (76%), Gaps = 21/858 (2%)
Frame = +1
Query: 2254 MTSARPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVS 2433
M +ARPRRMSEV A+ + PIP +S F+ S TN FRVFC+ + NHS F N +L CI+ S
Sbjct: 1298 MITARPRRMSEVNTATKILPIPPGTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCCIMFS 1357
Query: 2434 SAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLD 2613
SAMLAAE+PL+AN N +LN FDYFFT+VFT+E+ LK+I +G V H G+FCR+AFNLLD
Sbjct: 1358 SAMLAAENPLRANDDLNKVLNKFDYFFTAVFTMELILKLISYGFVLHDGAFCRSAFNLLD 1417
Query: 2614 ILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIM 2793
+LVV VSL S V +DA+S AINRAKGLKHVVQCVIVAVKTIGNI+
Sbjct: 1418 LLVVCVSLISLVSSSDAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIV 1477
Query: 2794 LVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSN 2973
LVT +LQFMFA+IGVQLFKG FF C D SKMT+ EC G Y+ Y+DGD KP ++R WSN
Sbjct: 1478 LVTCLLQFMFAVIGVQLFKGKFFKCTDGSKMTQDECYGTYLVYDDGDVHKPRLREREWSN 1537
Query: 2974 NDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXX 3153
N F+FD+V M++LF VSTFEGWP LLYV+IDSN+E+ GPIHN R VA
Sbjct: 1538 NRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIII 1597
Query: 3154 XXXXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVW 3333
GFVIVTFQNEGE+EY+NC+LDKNQR CIEFALKAKP RRYIP++ +QY+VW
Sbjct: 1598 AFFMVNIFVGFVIVTFQNEGEQEYKNCDLDKNQRNCIEFALKAKPVRRYIPKHGIQYKVW 1657
Query: 3334 WFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVAL 3513
WFVTS +FEY IF++I++NTV+LA K Y + + LD N+IFT VFA E V K+ A
Sbjct: 1658 WFVTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAF 1717
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNP---------------------GGTNLIS 3630
KNY D WNVFD ++V+GSFIDI Y ++ G+NLIS
Sbjct: 1718 RFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLIS 1777
Query: 3631 INFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGK 3810
INFFRLFRVMRLVKLLS+GEGIRTLLWTF+KSFQALPYVALLIVLLFFIYAV+GMQ FGK
Sbjct: 1778 INFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGK 1837
Query: 3811 VALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGG 3990
+ALD +I NNNF +F A+LVLFRSATGEAWQ+IM+SCS + DV+CD SD +
Sbjct: 1838 IALDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSDTPGEP- 1896
Query: 3991 LNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLW 4170
CG++ AYPYFISF++LCSFL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF+RLW
Sbjct: 1897 -----CGSSIAYPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLW 1951
Query: 4171 SEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNAT 4350
SEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNAT
Sbjct: 1952 SEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVLFNAT 2011
Query: 4351 LFALVRTNLKIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYA 4530
LFA+VRT+L I T+GNID+AN +LR+ IK+IWKRT+ LLD+VVPP G +D+VTVGKFYA
Sbjct: 2012 LFAVVRTSLSIKTDGNIDDANSELRATIKQIWKRTNPKLLDQVVPPPGNDDEVTVGKFYA 2071
Query: 4531 TFLIQDYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFN 4710
T+LIQDYFRRFKKRKE E K P + LQAGLRTLHE+ P LKRAISGNL D
Sbjct: 2072 TYLIQDYFRRFKKRKEQEGKEGHP--DSNTVTLQAGLRTLHEVSPALKRAISGNL--DEL 2127
Query: 4711 FDEPEPQHRRPHSLFNNL 4764
EPEP HRR H+LF ++
Sbjct: 2128 DQEPEPMHRRHHTLFGSV 2145
Score = 727 bits (1877), Expect = 0.0
Identities = 373/644 (57%), Positives = 442/644 (67%), Gaps = 5/644 (0%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+R LCI IVEWKPFEFLIL I ANCIALA+Y PYP DS+ N LE +EYVF+V+F
Sbjct: 602 NPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFLVIF 661
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
T ECV+KI+A GF+ H AYL N WN+LDF IVV+G +ST LS++ FDVKALRAFRV
Sbjct: 662 TAECVMKILAYGFVLHDGAYLGNGWNLLDFTIVVMGAISTALSQLMKDAFDVKALRAFRV 721
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLRLVSGVPSLQVVLN+IL+AM+PL HIALLVLFVI+IYAIIGLELF GKLH C D
Sbjct: 722 LRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKACRDE 781
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
TG+ +++ PCG ++C P ++C W GPN+GITNFDNFGL
Sbjct: 782 ITGEY-EENIRPCGV-----GYQCPPG---------YKCYGG--WDGPNDGITNFDNFGL 824
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKE 1122
AMLTVFQCV+LEGWTDV+Y + DA+G +W W+YF+++VILG+FFV+NL+LGVLSGEFSKE
Sbjct: 825 AMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKE 884
Query: 1123 REKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEP-----VNEDEQEDEPVAQTXXX 1287
R KA+ RG FQK REKQQ+EEDL+GYLDWITQAEDIEP + D + +P
Sbjct: 885 RNKAKNRGDFQKLREKQQIEEDLRGYLDWITQAEDIEPDAVGGLISDGKGKQP---NEMD 941
Query: 1288 XXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXX 1467
S+W K +++N VKSQ FYW
Sbjct: 942 STENLGEEMPEVQMTESRWRKMKKDFDRVNRRMRRACRKAVKSQAFYWLIIVLVFLNTGV 1001
Query: 1468 XTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSI 1647
+EHYGQ +WLD+FQ N+FF+ LF+ EMLLKMYSLGF Y S FNRFDCFVVI SI
Sbjct: 1002 LATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSI 1061
Query: 1648 LEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXX 1827
E +L +M PLGVSVLR RLLR+FKVTKYW
Sbjct: 1062 TETLLTNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFL 1121
Query: 1828 XXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESF 2007
GMQVFGGKFNF+ ++ K R NFD F QALLTVFQI+TGEDWN VMY GI ++
Sbjct: 1122 FIVIFALLGMQVFGGKFNFDGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAY 1181
Query: 2008 GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLT 2139
GGV + G + CIY+I+LFICGNYILLNVFLAIAVDNLADADSL+
Sbjct: 1182 GGVSSYGALACIYFIILFICGNYILLNVFLAIAVDNLADADSLS 1225
Score = 117 bits (293), Expect = 3e-24
Identities = 89/312 (28%), Positives = 148/312 (46%), Gaps = 9/312 (2%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
N R C + F +IL I + LA P A D N +L +Y F VF
Sbjct: 1331 NRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRANDD--LNKVLNKFDYFFTAVF 1388
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
T+E +LK+++ GF+ H A+ R+A+N+LD ++V + L+S + S +I VK LR RV
Sbjct: 1389 TMELILKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLISLVSSSDAIS--VVKILRVLRV 1446
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLR ++ L+ V+ ++ A+ + +I L+ + ++A+IG++LF GK C D
Sbjct: 1447 LRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKGKFFK-CTD- 1504
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
G +D + G+ D V W +N +FD+
Sbjct: 1505 --GSKMTQD------ECYGTYLVYDDGD------VHKPRLREREW---SNNRFHFDDVAK 1547
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDAVGREWPWI---------YFVTLVILGSFFVLNLVLG 1095
MLT+F + EGW ++Y D+ I Y++ +I+ +FF++N+ +G
Sbjct: 1548 GMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVG 1607
Query: 1096 VLSGEFSKEREK 1131
+ F E E+
Sbjct: 1608 FVIVTFQNEGEQ 1619
Score = 110 bits (274), Expect = 5e-22
Identities = 71/254 (27%), Positives = 126/254 (48%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S+AF ++I +++ +NT LA +HY ++F + N+ F G+F E +LK+ +L
Sbjct: 982 VKSQAFYWLIIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGF 1041
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD VV+GS + N G + ++ R R++R+ K+ +
Sbjct: 1042 QGYFVSLFNRFDCFVVIGSITETLL--TNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLS 1099
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAIL 3879
L+ + + S Q++ + LL+ L I+A++GMQ FG D NF F A+L
Sbjct: 1100 NLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNFDGKEEKYRMNFDCFWQALL 1159
Query: 3880 VLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCS 4059
+F+ TGE W +M + GG++ A YFI F+ +
Sbjct: 1160 TVFQIMTGEDWNAVMYVGINA-------------YGGVSSY---GALACIYFIILFICGN 1203
Query: 4060 FLVINLFVAVIMDN 4101
++++N+F+A+ +DN
Sbjct: 1204 YILLNVFLAIAVDN 1217
Score = 102 bits (254), Expect = 1e-19
Identities = 143/700 (20%), Positives = 252/700 (35%), Gaps = 70/700 (10%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
N +R+ C V+ + F +LI+ ++ N LA D+ + E FI +
Sbjct: 971 NRRMRRACRKAVKSQAFYWLIIVLVFLNTGVLATEH---YGQLDWLDNFQEYTNVFFIGL 1027
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG-FDVKALRAF 576
FT E +LK+ ++GF Y + +N D +V+ + T+L+ + V LR
Sbjct: 1028 FTCEMLLKMYSLGFQ----GYFVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCV 1083
Query: 577 RVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI 756
R+LR ++ SL ++ ++L ++ + + LL+ I+I+A++G+++F
Sbjct: 1084 RLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVF--------- 1134
Query: 757 DPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNF 936
G F + M NFD F
Sbjct: 1135 --------------------GGKFNFDGKEEKYRM--------------------NFDCF 1154
Query: 937 GLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPW-----IYFVTLVILGSFFVLNLVLGVL 1101
A+LTVFQ ++ E W VMY +A G + IYF+ L I G++ +LN+ L +
Sbjct: 1155 WQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIILFICGNYILLNVFLAIA 1214
Query: 1102 SGEFSKEREKARARGLFQKFREKQQLEED-----LKGYLDWITQAEDIEPVNEDEQEDEP 1266
+ + + E Q + + G D ++ D+E D+ ED+
Sbjct: 1215 VDNLADADSLSEVEKEEEPHDESAQKKSHSPTPTIDGMDDHLSIDIDMEQQELDD-EDKM 1273
Query: 1267 VAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXX-----XXXLVKSQT--- 1422
+T AR +R+ ++N + SQT
Sbjct: 1274 DHETLSDEEVREMCEEEEEVDEEGMITARPRRMSEVNTATKILPIPPGTSFFLFSQTNRF 1333
Query: 1423 ---FYWXXXXXXX----------XXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEML 1563
+W ++ L+ + FF +F+ME++
Sbjct: 1334 RVFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRANDDLNKVLNKFDYFFTAVFTMELI 1393
Query: 1564 LKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIF 1731
LK+ S GF + S FN D VV S++ V + V +LR R+LR
Sbjct: 1394 LKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLISLVSSSDAISV---VKILRVLRVLRPL 1450
Query: 1732 KVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF----------- 1878
+ G+Q+F GKF
Sbjct: 1451 RAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKGKFFKCTDGSKMTQ 1510
Query: 1879 -----------NFNPQQPKPRA--------NFDTFVQALLTVFQILTGEDWNTVMYHGI- 1998
+ + +P+ R +FD + +LT+F + T E W ++Y I
Sbjct: 1511 DECYGTYLVYDDGDVHKPRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSID 1570
Query: 1999 ---ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
E+ G + IV YYI+ I + ++N+F+ +
Sbjct: 1571 SNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVI 1610
Score = 95.5 bits (236), Expect = 1e-17
Identities = 75/291 (25%), Positives = 128/291 (43%), Gaps = 39/291 (13%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLAC-KHYPSSRG--FEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE++I L I N ++LA YP S L+ +F +F E V+KI+A
Sbjct: 615 KPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFLVIFTAECVMKILAYGF 674
Query: 3511 -LNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRG 3687
L+ Y+ + WN+ D +VV I +L + + R FRV+R ++L+S
Sbjct: 675 VLHDGAYLGNGWNLLDFTIVVMGAISTALSQLMK---DAFDVKALRAFRVLRPLRLVSGV 731
Query: 3688 EGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFG----KVALDDSTSIHRNN-- 3849
++ +L + +K+ L ++ALL++ + IYA+IG++ F K D+ T + N
Sbjct: 732 PSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKACRDEITGEYEENIR 791
Query: 3850 --------------------------NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDV 3951
NF +F A+L +F+ T E W D++ S D
Sbjct: 792 PCGVGYQCPPGYKCYGGWDGPNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQD---- 847
Query: 3952 RCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
G+++ + YFIS +L +F V+NL + V+ F
Sbjct: 848 -----------------AMGSDWQWMYFISMVILGAFFVMNLILGVLSGEF 881
Score = 94.4 bits (233), Expect = 3e-17
Identities = 73/266 (27%), Positives = 114/266 (42%), Gaps = 13/266 (4%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR--NMILNYF 2502
+LF LS N R C +V F +L I + LA P + + N L
Sbjct: 594 ALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKV 653
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV---AVSLTSFVLRTDAMSX 2673
+Y F +FT E +K++ +G V H G++ N +NLLD +V A+S L DA
Sbjct: 654 EYVFLVIFTAECVMKILAYGFVLHDGAYLGNGWNLLDFTIVVMGAISTALSQLMKDAFD- 712
Query: 2674 XXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKG 2853
++ L+ V+ ++ A+ + +I L+ + ++AIIG++LF G
Sbjct: 713 VKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSG 772
Query: 2854 TFFLCNDLSKMTEAECRGEY--------IHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAM 3009
L K E GEY + Y+ K ++ NFDN G AM
Sbjct: 773 ------KLHKACRDEITGEYEENIRPCGVGYQCPPGYKCYGGWDGPNDGITNFDNFGLAM 826
Query: 3010 ISLFVVSTFEGWPQLLYVAIDSNEED 3087
+++F T EGW +LY D+ D
Sbjct: 827 LTVFQCVTLEGWTDVLYSIQDAMGSD 852
Score = 79.3 bits (194), Expect = 1e-12
Identities = 82/371 (22%), Positives = 148/371 (39%), Gaps = 48/371 (12%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIY---QPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMG 438
FE+ I +I N + LA+ QP + LL+ + +F VF +E V K+ A
Sbjct: 1665 FEYTIFILIMINTVTLAMKFYNQPL------WYTELLDALNMIFTAVFALEFVFKLAAFR 1718
Query: 439 FMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMS------------IQG----------- 549
F Y +AWN+ DFIIV+ + + S++ ++G
Sbjct: 1719 F----KNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSN 1774
Query: 550 -FDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLEL 726
+ R FRV+R ++L+S ++ +L +++ L ++ALL++ + IYA++G+++
Sbjct: 1775 LISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQV 1834
Query: 727 FCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGP 906
F GK+ +D A
Sbjct: 1835 F-GKI---ALDGGNAITA------------------------------------------ 1848
Query: 907 NNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVN---------------DAVGREWPWIY 1041
NN NF F A+L +F+ + E W ++M + + G + Y
Sbjct: 1849 NN---NFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSDTPGEPCGSSIAYPY 1905
Query: 1042 FVTLVILGSFFVLNLVLGVLSGEF---SKEREKARARGLFQKFREKQQLEEDLKG---YL 1203
F++ +L SF ++NL + V+ F +++ L + R + + D KG +L
Sbjct: 1906 FISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLWSEYDPDAKGRIKHL 1965
Query: 1204 DWITQAEDIEP 1236
D +T I P
Sbjct: 1966 DVVTLLRKISP 1976
Score = 60.1 bits (144), Expect = 6e-07
Identities = 53/269 (19%), Positives = 97/269 (35%), Gaps = 33/269 (12%)
Frame = +1
Query: 1408 VKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGF 1587
V S +F + + Y Q W N+ F +F++E + K+ + F
Sbjct: 1660 VTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRF 1719
Query: 1588 TTYTTSQFNRFDCFVVISSILEFV-----------LVYFDLMKP------------LGVS 1698
Y +N FD +V+ S ++ V + D+++ + ++
Sbjct: 1720 KNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISIN 1779
Query: 1699 VLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF 1878
R R++R+ K+ GMQVFG
Sbjct: 1780 FFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGKIA 1839
Query: 1879 NFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYH-----GIESFGGVGTLG----- 2028
NF TF QA+L +F+ TGE W +M ++ T G
Sbjct: 1840 LDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSDTPGEPCGS 1899
Query: 2029 VIVCIYYIVLFICGNYILLNVFLAIAVDN 2115
I Y+I ++ +++++N+F+A+ +DN
Sbjct: 1900 SIAYPYFISFYVLCSFLIINLFVAVIMDN 1928
Score = 58.5 bits (140), Expect = 2e-06
Identities = 55/238 (23%), Positives = 98/238 (41%), Gaps = 3/238 (1%)
Frame = +1
Query: 2371 CNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKV 2550
C V F ++ + +++ +LA E Q + N Y + FF +FT E+ LK+
Sbjct: 978 CRKAVKSQAFYWLIIVLVFLNTGVLATEHYGQLDWLDNF-QEYTNVFFIGLFTCEMLLKM 1036
Query: 2551 IVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRA 2730
G +G F + FN D VV S+T +L M
Sbjct: 1037 YSLGF---QGYFV-SLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLLRVFKVT 1092
Query: 2731 K---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAEC 2901
K L ++V ++ ++++I +++L+ F+ +FA++G+Q+F G F
Sbjct: 1093 KYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNF------------ 1140
Query: 2902 RGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
DG K NFD A++++F + T E W ++YV I++
Sbjct: 1141 --------DGKEEK----------YRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINA 1180
Score = 39.7 bits (91), Expect = 0.85
Identities = 22/64 (34%), Positives = 36/64 (55%), Gaps = 3/64 (4%)
Frame = +1
Query: 5299 PFSSRPVLRPAEDSRPVDRLIGQSL---GLGRYADARIVGAARREIEEAYSLGEQEIDLA 5469
P+ R + ++ + + LIG L GLG+Y D+ VG A RE+ EA + +E++LA
Sbjct: 2316 PYDQRRLPTSSDMNGLAESLIGGVLAAEGLGKYCDSEFVGTAAREMREALDMTPEEMNLA 2375
Query: 5470 ADSL 5481
A +
Sbjct: 2376 AHQI 2379
>gi|24584549|ref|NP_525104.2| CG4894-PB [Drosophila melanogaster]
gi|22946601|gb|AAN10929.1| CG4894-PB [Drosophila melanogaster]
Length = 2519
Score = 1111 bits (2874), Expect = 0.0
Identities = 559/856 (65%), Positives = 657/856 (76%), Gaps = 21/856 (2%)
Frame = +1
Query: 2260 SARPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSA 2439
+ARPRR+SEV T KPIP+ S+ FI S+TN FRVFC+ + NHS F N +L CI+ SSA
Sbjct: 1303 TARPRRLSEVSMKKTKKPIPRGSAFFIFSYTNRFRVFCHWLCNHSNFGNIILCCIMFSSA 1362
Query: 2440 MLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDIL 2619
MLAAE+PL+AN N +LN FDYFFT+VFT+E+ LK+I +G V H G+FCR+AFNLLD+L
Sbjct: 1363 MLAAENPLRANDDLNKVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDLL 1422
Query: 2620 VVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLV 2799
VV VSL S V ++A+S AINRAKGLKHVVQCVIVAVKTIGNI+LV
Sbjct: 1423 VVCVSLISLVSSSNAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLV 1482
Query: 2800 TFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNND 2979
T +LQFMFA+IGVQLFKG FF C D SKMT+ EC G Y+ Y+DGD KP ++R WSNN
Sbjct: 1483 TCLLQFMFAVIGVQLFKGKFFKCTDGSKMTQDECYGTYLVYDDGDVHKPRLREREWSNNR 1542
Query: 2980 FNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXX 3159
F+FD+V M++LF VSTFEGWP LLYV+IDSN+E+ GPIHN R VA
Sbjct: 1543 FHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAF 1602
Query: 3160 XXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWF 3339
GFVIVTFQNEGE+EY+NC+LDKNQR CIEFALKAKP RRYIP++ +QY+VWWF
Sbjct: 1603 FMVNIFVGFVIVTFQNEGEQEYKNCDLDKNQRNCIEFALKAKPVRRYIPKHGIQYKVWWF 1662
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
VTS +FEY IF++I++NTV+LA K Y + + LD N+IFT VFA E V K+ A
Sbjct: 1663 VTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRF 1722
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNP---------------------GGTNLISIN 3636
KNY D WNVFD ++V+GSFIDI Y ++ G+NLISIN
Sbjct: 1723 KNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISIN 1782
Query: 3637 FFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVA 3816
FFRLFRVMRLVKLLS+GEGIRTLLWTF+KSFQALPYVALLIVLLFFIYAV+GMQ FGK+A
Sbjct: 1783 FFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGKIA 1842
Query: 3817 LDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLN 3996
LD +I NNNF +F A+LVLFRSATGEAWQ+IM+SCS + DV+CD SD +
Sbjct: 1843 LDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSDTPGEP--- 1899
Query: 3997 ESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSE 4176
CG++ AYPYFISF++LCSFL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF+RLWSE
Sbjct: 1900 ---CGSSIAYPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLWSE 1956
Query: 4177 YDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLF 4356
YDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLF
Sbjct: 1957 YDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVLFNATLF 2016
Query: 4357 ALVRTNLKIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATF 4536
A+VRT+L I T+GNID+AN +LR+ IK+IWKRT+ LLD+VVPP G +D+VTVGKFYAT+
Sbjct: 2017 AVVRTSLSIKTDGNIDDANSELRATIKQIWKRTNPKLLDQVVPPPGNDDEVTVGKFYATY 2076
Query: 4537 LIQDYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFD 4716
LIQDYFRRFKKRKE E K P + LQAGLRTLHE+ P LKRAISGNL D
Sbjct: 2077 LIQDYFRRFKKRKEQEGKEGHP--DSNTVTLQAGLRTLHEVSPALKRAISGNL--DELDQ 2132
Query: 4717 EPEPQHRRPHSLFNNL 4764
EPEP HRR H+LF ++
Sbjct: 2133 EPEPMHRRHHTLFGSV 2148
Score = 731 bits (1886), Expect = 0.0
Identities = 375/644 (58%), Positives = 443/644 (68%), Gaps = 5/644 (0%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+R LCI IVEWKPFEFLIL I ANCIALA+Y PYP DS+ N LE +EYVF+V+F
Sbjct: 602 NPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFLVIF 661
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
T ECV+KI+A GF+ H AYLRN WN+LDF IVVIG +ST LS++ FDVKALRAFRV
Sbjct: 662 TAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMKDAFDVKALRAFRV 721
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLRLVSGVPSLQVVLN+IL+AM+PL HIALLVLFVI+IYAIIGLELF GKLH C D
Sbjct: 722 LRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKACRDE 781
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
TG+ +++ PCG ++C P ++C W GPN+GITNFDNFGL
Sbjct: 782 ITGEY-EENIRPCGV-----GYQCPPG---------YKCYGG--WDGPNDGITNFDNFGL 824
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKE 1122
AMLTVFQCV+LEGWTDV+Y + DA+G +W W+YF+++VILG+FFV+NL+LGVLSGEFSKE
Sbjct: 825 AMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKE 884
Query: 1123 REKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEP-----VNEDEQEDEPVAQTXXX 1287
R KA+ RG FQK REKQQ+EEDL+GYLDWITQAEDIEP + D + +P
Sbjct: 885 RNKAKNRGDFQKLREKQQIEEDLRGYLDWITQAEDIEPDAVGGLISDGKGKQP---NEMD 941
Query: 1288 XXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXX 1467
S+W K +++N VKSQ FYW
Sbjct: 942 STENLGEEMPEVQMTESRWRKMKKDFDRVNRRMRRACRKAVKSQAFYWLIIVLVFLNTGV 1001
Query: 1468 XTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSI 1647
+EHYGQ +WLD+FQ N+FF+ LF+ EMLLKMYSLGF Y S FNRFDCFVVI SI
Sbjct: 1002 LATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSI 1061
Query: 1648 LEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXX 1827
E +L +M PLGVSVLR RLLR+FKVTKYW
Sbjct: 1062 TETLLTNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFL 1121
Query: 1828 XXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESF 2007
GMQVFGGKFNF+ ++ K R NFD F QALLTVFQI+TGEDWN VMY GI ++
Sbjct: 1122 FIVIFALLGMQVFGGKFNFDGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAY 1181
Query: 2008 GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLT 2139
GGV + G + CIY+I+LFICGNYILLNVFLAIAVDNLADADSL+
Sbjct: 1182 GGVSSYGALACIYFIILFICGNYILLNVFLAIAVDNLADADSLS 1225
Score = 119 bits (297), Expect = 1e-24
Identities = 90/312 (28%), Positives = 148/312 (46%), Gaps = 9/312 (2%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
N R C + F +IL I + LA P A D N +L +Y F VF
Sbjct: 1334 NRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRANDD--LNKVLNKFDYFFTAVF 1391
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
TIE +LK+++ GF+ H A+ R+A+N+LD ++V + L+S + S +I VK LR RV
Sbjct: 1392 TIELILKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLISLVSSSNAIS--VVKILRVLRV 1449
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLR ++ L+ V+ ++ A+ + +I L+ + ++A+IG++LF GK C D
Sbjct: 1450 LRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKGKFFK-CTD- 1507
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
G +D + G+ D V W +N +FD+
Sbjct: 1508 --GSKMTQD------ECYGTYLVYDDGD------VHKPRLREREW---SNNRFHFDDVAK 1550
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDAVGREWPWI---------YFVTLVILGSFFVLNLVLG 1095
MLT+F + EGW ++Y D+ I Y++ +I+ +FF++N+ +G
Sbjct: 1551 GMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVG 1610
Query: 1096 VLSGEFSKEREK 1131
+ F E E+
Sbjct: 1611 FVIVTFQNEGEQ 1622
Score = 110 bits (274), Expect = 5e-22
Identities = 71/254 (27%), Positives = 126/254 (48%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S+AF ++I +++ +NT LA +HY ++F + N+ F G+F E +LK+ +L
Sbjct: 982 VKSQAFYWLIIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGF 1041
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD VV+GS + N G + ++ R R++R+ K+ +
Sbjct: 1042 QGYFVSLFNRFDCFVVIGSITETLL--TNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLS 1099
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAIL 3879
L+ + + S Q++ + LL+ L I+A++GMQ FG D NF F A+L
Sbjct: 1100 NLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNFDGKEEKYRMNFDCFWQALL 1159
Query: 3880 VLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCS 4059
+F+ TGE W +M + GG++ A YFI F+ +
Sbjct: 1160 TVFQIMTGEDWNAVMYVGINA-------------YGGVSSY---GALACIYFIILFICGN 1203
Query: 4060 FLVINLFVAVIMDN 4101
++++N+F+A+ +DN
Sbjct: 1204 YILLNVFLAIAVDN 1217
Score = 98.2 bits (243), Expect = 2e-18
Identities = 73/266 (27%), Positives = 114/266 (42%), Gaps = 13/266 (4%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR--NMILNYF 2502
+LF LS N R C +V F +L I + LA P + + N L
Sbjct: 594 ALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKV 653
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXX 2682
+Y F +FT E +K++ +G V H G++ RN +NLLD +V + S L + M
Sbjct: 654 EYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTAL-SQLMKDAFD 712
Query: 2683 XXXXXXXXXXXAINRAKG---LKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKG 2853
+ G L+ V+ ++ A+ + +I L+ + ++AIIG++LF G
Sbjct: 713 VKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSG 772
Query: 2854 TFFLCNDLSKMTEAECRGEY--------IHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAM 3009
L K E GEY + Y+ K ++ NFDN G AM
Sbjct: 773 ------KLHKACRDEITGEYEENIRPCGVGYQCPPGYKCYGGWDGPNDGITNFDNFGLAM 826
Query: 3010 ISLFVVSTFEGWPQLLYVAIDSNEED 3087
+++F T EGW +LY D+ D
Sbjct: 827 LTVFQCVTLEGWTDVLYSIQDAMGSD 852
Score = 94.4 bits (233), Expect = 3e-17
Identities = 75/291 (25%), Positives = 128/291 (43%), Gaps = 39/291 (13%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLAC-KHYPSSRG--FEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE++I L I N ++LA YP S L+ +F +F E V+KI+A
Sbjct: 615 KPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFLVIFTAECVMKILAYGF 674
Query: 3511 -LNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRG 3687
L+ Y+ + WN+ D +VV I +L + + R FRV+R ++L+S
Sbjct: 675 VLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMK---DAFDVKALRAFRVLRPLRLVSGV 731
Query: 3688 EGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFG----KVALDDSTSIHRNN-- 3849
++ +L + +K+ L ++ALL++ + IYA+IG++ F K D+ T + N
Sbjct: 732 PSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKACRDEITGEYEENIR 791
Query: 3850 --------------------------NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDV 3951
NF +F A+L +F+ T E W D++ S D
Sbjct: 792 PCGVGYQCPPGYKCYGGWDGPNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQD---- 847
Query: 3952 RCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
G+++ + YFIS +L +F V+NL + V+ F
Sbjct: 848 -----------------AMGSDWQWMYFISMVILGAFFVMNLILGVLSGEF 881
Score = 79.3 bits (194), Expect = 1e-12
Identities = 82/371 (22%), Positives = 148/371 (39%), Gaps = 48/371 (12%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIY---QPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMG 438
FE+ I +I N + LA+ QP + LL+ + +F VF +E V K+ A
Sbjct: 1668 FEYTIFILIMINTVTLAMKFYNQPL------WYTELLDALNMIFTAVFALEFVFKLAAFR 1721
Query: 439 FMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMS------------IQG----------- 549
F Y +AWN+ DFIIV+ + + S++ ++G
Sbjct: 1722 F----KNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSN 1777
Query: 550 -FDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLEL 726
+ R FRV+R ++L+S ++ +L +++ L ++ALL++ + IYA++G+++
Sbjct: 1778 LISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQV 1837
Query: 727 FCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGP 906
F GK+ +D A
Sbjct: 1838 F-GKI---ALDGGNAITA------------------------------------------ 1851
Query: 907 NNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVN---------------DAVGREWPWIY 1041
NN NF F A+L +F+ + E W ++M + + G + Y
Sbjct: 1852 NN---NFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSDTPGEPCGSSIAYPY 1908
Query: 1042 FVTLVILGSFFVLNLVLGVLSGEF---SKEREKARARGLFQKFREKQQLEEDLKG---YL 1203
F++ +L SF ++NL + V+ F +++ L + R + + D KG +L
Sbjct: 1909 FISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLWSEYDPDAKGRIKHL 1968
Query: 1204 DWITQAEDIEP 1236
D +T I P
Sbjct: 1969 DVVTLLRKISP 1979
Score = 60.1 bits (144), Expect = 6e-07
Identities = 53/269 (19%), Positives = 97/269 (35%), Gaps = 33/269 (12%)
Frame = +1
Query: 1408 VKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGF 1587
V S +F + + Y Q W N+ F +F++E + K+ + F
Sbjct: 1663 VTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRF 1722
Query: 1588 TTYTTSQFNRFDCFVVISSILEFV-----------LVYFDLMKP------------LGVS 1698
Y +N FD +V+ S ++ V + D+++ + ++
Sbjct: 1723 KNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISIN 1782
Query: 1699 VLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF 1878
R R++R+ K+ GMQVFG
Sbjct: 1783 FFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGKIA 1842
Query: 1879 NFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYH-----GIESFGGVGTLG----- 2028
NF TF QA+L +F+ TGE W +M ++ T G
Sbjct: 1843 LDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSDTPGEPCGS 1902
Query: 2029 VIVCIYYIVLFICGNYILLNVFLAIAVDN 2115
I Y+I ++ +++++N+F+A+ +DN
Sbjct: 1903 SIAYPYFISFYVLCSFLIINLFVAVIMDN 1931
Score = 58.5 bits (140), Expect = 2e-06
Identities = 55/238 (23%), Positives = 98/238 (41%), Gaps = 3/238 (1%)
Frame = +1
Query: 2371 CNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKV 2550
C V F ++ + +++ +LA E Q + N Y + FF +FT E+ LK+
Sbjct: 978 CRKAVKSQAFYWLIIVLVFLNTGVLATEHYGQLDWLDNF-QEYTNVFFIGLFTCEMLLKM 1036
Query: 2551 IVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRA 2730
G +G F + FN D VV S+T +L M
Sbjct: 1037 YSLGF---QGYFV-SLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLLRVFKVT 1092
Query: 2731 K---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAEC 2901
K L ++V ++ ++++I +++L+ F+ +FA++G+Q+F G F
Sbjct: 1093 KYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNF------------ 1140
Query: 2902 RGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
DG K NFD A++++F + T E W ++YV I++
Sbjct: 1141 --------DGKEEK----------YRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINA 1180
Score = 50.8 bits (120), Expect = 4e-04
Identities = 51/231 (22%), Positives = 86/231 (37%), Gaps = 38/231 (16%)
Frame = +1
Query: 1531 FFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVS 1698
FF +F++E++LK+ S GF + S FN D VV S++ V + V
Sbjct: 1386 FFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLISLVSSSNAISV---VK 1442
Query: 1699 VLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF 1878
+LR R+LR + G+Q+F GKF
Sbjct: 1443 ILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKGKF 1502
Query: 1879 ----------------------NFNPQQPKPRA--------NFDTFVQALLTVFQILTGE 1968
+ + +P+ R +FD + +LT+F + T E
Sbjct: 1503 FKCTDGSKMTQDECYGTYLVYDDGDVHKPRLREREWSNNRFHFDDVAKGMLTLFTVSTFE 1562
Query: 1969 DWNTVMYHGI----ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
W ++Y I E+ G + IV YYI+ I + ++N+F+ +
Sbjct: 1563 GWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVI 1613
Score = 39.7 bits (91), Expect = 0.85
Identities = 22/64 (34%), Positives = 36/64 (55%), Gaps = 3/64 (4%)
Frame = +1
Query: 5299 PFSSRPVLRPAEDSRPVDRLIGQSL---GLGRYADARIVGAARREIEEAYSLGEQEIDLA 5469
P+ R + ++ + + LIG L GLG+Y D+ VG A RE+ EA + +E++LA
Sbjct: 2319 PYDQRRLPTSSDMNGLAESLIGGVLAAEGLGKYCDSEFVGTAAREMREALDMTPEEMNLA 2378
Query: 5470 ADSL 5481
A +
Sbjct: 2379 AHQI 2382
>gi|19584591|ref|NP_602305.1| CG4894-PA [Drosophila melanogaster]
gi|32172454|sp|Q24270|CCAD_DROME Voltage-dependent calcium channel
type D alpha-1 subunit (DmCA1D)
gi|7287948|gb|AAF44986.1| symbol=Ca-alpha1D; synonym=BG:DS02795.1;
match=method:''sim4'', score:''1000.0'',
desc:''GenBank::U00690:2 Ca-&agr;1D FBgn0001991
PID:g457927 SPTREMBL:Q24270'', species:''Drosophila
melanogaster''; match=method:''BLASTX'',
version:''2.0a19MP-WashU [05-Feb-1998] [Build
sol2.5-ultra 01:47:30 05-Feb-1998]'', score:''897.0'',
desc:''trEMBL::Q13916:NEUROENDOCRINE/BETA-CELL-TYPE
CALCIUM CHANNEL ALPHA 1 SUBUNIT. organism:HOMO SAPIENS
(HUMAN). dbxref:GenBank; M83566; g179752; -.'',
species:''HOMO SAPIENS
gi|7298274|gb|AAF53504.1| CG4894-PA [Drosophila melanogaster]
Length = 2516
Score = 1110 bits (2872), Expect = 0.0
Identities = 559/858 (65%), Positives = 657/858 (76%), Gaps = 21/858 (2%)
Frame = +1
Query: 2254 MTSARPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVS 2433
M +ARPRRMSEV A+ + PIP +S F+ S TN FRVFC+ + NHS F N +L CI+ S
Sbjct: 1298 MITARPRRMSEVNTATKILPIPPGTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCCIMFS 1357
Query: 2434 SAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLD 2613
SAMLAAE+PL+AN N +LN FDYFFT+VFT+E+ LK+I +G V H G+FCR+AFNLLD
Sbjct: 1358 SAMLAAENPLRANDDLNKVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLD 1417
Query: 2614 ILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIM 2793
+LVV VSL S V ++A+S AINRAKGLKHVVQCVIVAVKTIGNI+
Sbjct: 1418 LLVVCVSLISLVSSSNAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIV 1477
Query: 2794 LVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSN 2973
LVT +LQFMFA+IGVQLFKG FF C D SKMT+ EC G Y+ Y+DGD KP ++R WSN
Sbjct: 1478 LVTCLLQFMFAVIGVQLFKGKFFKCTDGSKMTQDECYGTYLVYDDGDVHKPRLREREWSN 1537
Query: 2974 NDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXX 3153
N F+FD+V M++LF VSTFEGWP LLYV+IDSN+E+ GPIHN R VA
Sbjct: 1538 NRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIII 1597
Query: 3154 XXXXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVW 3333
GFVIVTFQNEGE+EY+NC+LDKNQR CIEFALKAKP RRYIP++ +QY+VW
Sbjct: 1598 AFFMVNIFVGFVIVTFQNEGEQEYKNCDLDKNQRNCIEFALKAKPVRRYIPKHGIQYKVW 1657
Query: 3334 WFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVAL 3513
WFVTS +FEY IF++I++NTV+LA K Y + + LD N+IFT VFA E V K+ A
Sbjct: 1658 WFVTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAF 1717
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNP---------------------GGTNLIS 3630
KNY D WNVFD ++V+GSFIDI Y ++ G+NLIS
Sbjct: 1718 RFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLIS 1777
Query: 3631 INFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGK 3810
INFFRLFRVMRLVKLLS+GEGIRTLLWTF+KSFQALPYVALLIVLLFFIYAV+GMQ FGK
Sbjct: 1778 INFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGK 1837
Query: 3811 VALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGG 3990
+ALD +I NNNF +F A+LVLFRSATGEAWQ+IM+SCS + DV+CD SD +
Sbjct: 1838 IALDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSDTPGEP- 1896
Query: 3991 LNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLW 4170
CG++ AYPYFISF++LCSFL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF+RLW
Sbjct: 1897 -----CGSSIAYPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLW 1951
Query: 4171 SEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNAT 4350
SEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNAT
Sbjct: 1952 SEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVLFNAT 2011
Query: 4351 LFALVRTNLKIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYA 4530
LFA+VRT+L I T+GNID+AN +LR+ IK+IWKRT+ LLD+VVPP G +D+VTVGKFYA
Sbjct: 2012 LFAVVRTSLSIKTDGNIDDANSELRATIKQIWKRTNPKLLDQVVPPPGNDDEVTVGKFYA 2071
Query: 4531 TFLIQDYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFN 4710
T+LIQDYFRRFKKRKE E K P + LQAGLRTLHE+ P LKRAISGNL D
Sbjct: 2072 TYLIQDYFRRFKKRKEQEGKEGHP--DSNTVTLQAGLRTLHEVSPALKRAISGNL--DEL 2127
Query: 4711 FDEPEPQHRRPHSLFNNL 4764
EPEP HRR H+LF ++
Sbjct: 2128 DQEPEPMHRRHHTLFGSV 2145
Score = 731 bits (1886), Expect = 0.0
Identities = 375/644 (58%), Positives = 443/644 (68%), Gaps = 5/644 (0%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+R LCI IVEWKPFEFLIL I ANCIALA+Y PYP DS+ N LE +EYVF+V+F
Sbjct: 602 NPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFLVIF 661
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
T ECV+KI+A GF+ H AYLRN WN+LDF IVVIG +ST LS++ FDVKALRAFRV
Sbjct: 662 TAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMKDAFDVKALRAFRV 721
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLRLVSGVPSLQVVLN+IL+AM+PL HIALLVLFVI+IYAIIGLELF GKLH C D
Sbjct: 722 LRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKACRDE 781
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
TG+ +++ PCG ++C P ++C W GPN+GITNFDNFGL
Sbjct: 782 ITGEY-EENIRPCGV-----GYQCPPG---------YKCYGG--WDGPNDGITNFDNFGL 824
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKE 1122
AMLTVFQCV+LEGWTDV+Y + DA+G +W W+YF+++VILG+FFV+NL+LGVLSGEFSKE
Sbjct: 825 AMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKE 884
Query: 1123 REKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEP-----VNEDEQEDEPVAQTXXX 1287
R KA+ RG FQK REKQQ+EEDL+GYLDWITQAEDIEP + D + +P
Sbjct: 885 RNKAKNRGDFQKLREKQQIEEDLRGYLDWITQAEDIEPDAVGGLISDGKGKQP---NEMD 941
Query: 1288 XXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXX 1467
S+W K +++N VKSQ FYW
Sbjct: 942 STENLGEEMPEVQMTESRWRKMKKDFDRVNRRMRRACRKAVKSQAFYWLIIVLVFLNTGV 1001
Query: 1468 XTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSI 1647
+EHYGQ +WLD+FQ N+FF+ LF+ EMLLKMYSLGF Y S FNRFDCFVVI SI
Sbjct: 1002 LATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSI 1061
Query: 1648 LEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXX 1827
E +L +M PLGVSVLR RLLR+FKVTKYW
Sbjct: 1062 TETLLTNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFL 1121
Query: 1828 XXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESF 2007
GMQVFGGKFNF+ ++ K R NFD F QALLTVFQI+TGEDWN VMY GI ++
Sbjct: 1122 FIVIFALLGMQVFGGKFNFDGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAY 1181
Query: 2008 GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLT 2139
GGV + G + CIY+I+LFICGNYILLNVFLAIAVDNLADADSL+
Sbjct: 1182 GGVSSYGALACIYFIILFICGNYILLNVFLAIAVDNLADADSLS 1225
Score = 119 bits (297), Expect = 1e-24
Identities = 90/312 (28%), Positives = 148/312 (46%), Gaps = 9/312 (2%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
N R C + F +IL I + LA P A D N +L +Y F VF
Sbjct: 1331 NRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRANDD--LNKVLNKFDYFFTAVF 1388
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
TIE +LK+++ GF+ H A+ R+A+N+LD ++V + L+S + S +I VK LR RV
Sbjct: 1389 TIELILKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLISLVSSSNAIS--VVKILRVLRV 1446
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLR ++ L+ V+ ++ A+ + +I L+ + ++A+IG++LF GK C D
Sbjct: 1447 LRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKGKFFK-CTD- 1504
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
G +D + G+ D V W +N +FD+
Sbjct: 1505 --GSKMTQD------ECYGTYLVYDDGD------VHKPRLREREW---SNNRFHFDDVAK 1547
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDAVGREWPWI---------YFVTLVILGSFFVLNLVLG 1095
MLT+F + EGW ++Y D+ I Y++ +I+ +FF++N+ +G
Sbjct: 1548 GMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVG 1607
Query: 1096 VLSGEFSKEREK 1131
+ F E E+
Sbjct: 1608 FVIVTFQNEGEQ 1619
Score = 110 bits (274), Expect = 5e-22
Identities = 71/254 (27%), Positives = 126/254 (48%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S+AF ++I +++ +NT LA +HY ++F + N+ F G+F E +LK+ +L
Sbjct: 982 VKSQAFYWLIIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGF 1041
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD VV+GS + N G + ++ R R++R+ K+ +
Sbjct: 1042 QGYFVSLFNRFDCFVVIGSITETLL--TNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLS 1099
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAIL 3879
L+ + + S Q++ + LL+ L I+A++GMQ FG D NF F A+L
Sbjct: 1100 NLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNFDGKEEKYRMNFDCFWQALL 1159
Query: 3880 VLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCS 4059
+F+ TGE W +M + GG++ A YFI F+ +
Sbjct: 1160 TVFQIMTGEDWNAVMYVGINA-------------YGGVSSY---GALACIYFIILFICGN 1203
Query: 4060 FLVINLFVAVIMDN 4101
++++N+F+A+ +DN
Sbjct: 1204 YILLNVFLAIAVDN 1217
Score = 100 bits (250), Expect = 3e-19
Identities = 142/700 (20%), Positives = 252/700 (35%), Gaps = 70/700 (10%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
N +R+ C V+ + F +LI+ ++ N LA D+ + E FI +
Sbjct: 971 NRRMRRACRKAVKSQAFYWLIIVLVFLNTGVLATEH---YGQLDWLDNFQEYTNVFFIGL 1027
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG-FDVKALRAF 576
FT E +LK+ ++GF Y + +N D +V+ + T+L+ + V LR
Sbjct: 1028 FTCEMLLKMYSLGFQ----GYFVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCV 1083
Query: 577 RVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI 756
R+LR ++ SL ++ ++L ++ + + LL+ I+I+A++G+++F
Sbjct: 1084 RLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVF--------- 1134
Query: 757 DPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNF 936
G F + M NFD F
Sbjct: 1135 --------------------GGKFNFDGKEEKYRM--------------------NFDCF 1154
Query: 937 GLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPW-----IYFVTLVILGSFFVLNLVLGVL 1101
A+LTVFQ ++ E W VMY +A G + IYF+ L I G++ +LN+ L +
Sbjct: 1155 WQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIILFICGNYILLNVFLAIA 1214
Query: 1102 SGEFSKEREKARARGLFQKFREKQQLEED-----LKGYLDWITQAEDIEPVNEDEQEDEP 1266
+ + + E Q + + G D ++ D+E D+ ED+
Sbjct: 1215 VDNLADADSLSEVEKEEEPHDESAQKKSHSPTPTIDGMDDHLSIDIDMEQQELDD-EDKM 1273
Query: 1267 VAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXX-----XXXLVKSQT--- 1422
+T AR +R+ ++N + SQT
Sbjct: 1274 DHETLSDEEVREMCEEEEEVDEEGMITARPRRMSEVNTATKILPIPPGTSFFLFSQTNRF 1333
Query: 1423 ---FYWXXXXXXX----------XXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEML 1563
+W ++ L+ + FF +F++E++
Sbjct: 1334 RVFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRANDDLNKVLNKFDYFFTAVFTIELI 1393
Query: 1564 LKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIF 1731
LK+ S GF + S FN D VV S++ V + V +LR R+LR
Sbjct: 1394 LKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLISLVSSSNAISV---VKILRVLRVLRPL 1450
Query: 1732 KVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF----------- 1878
+ G+Q+F GKF
Sbjct: 1451 RAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKGKFFKCTDGSKMTQ 1510
Query: 1879 -----------NFNPQQPKPRA--------NFDTFVQALLTVFQILTGEDWNTVMYHGI- 1998
+ + +P+ R +FD + +LT+F + T E W ++Y I
Sbjct: 1511 DECYGTYLVYDDGDVHKPRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSID 1570
Query: 1999 ---ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
E+ G + IV YYI+ I + ++N+F+ +
Sbjct: 1571 SNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVI 1610
Score = 98.2 bits (243), Expect = 2e-18
Identities = 73/266 (27%), Positives = 114/266 (42%), Gaps = 13/266 (4%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR--NMILNYF 2502
+LF LS N R C +V F +L I + LA P + + N L
Sbjct: 594 ALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKV 653
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXX 2682
+Y F +FT E +K++ +G V H G++ RN +NLLD +V + S L + M
Sbjct: 654 EYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTAL-SQLMKDAFD 712
Query: 2683 XXXXXXXXXXXAINRAKG---LKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKG 2853
+ G L+ V+ ++ A+ + +I L+ + ++AIIG++LF G
Sbjct: 713 VKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSG 772
Query: 2854 TFFLCNDLSKMTEAECRGEY--------IHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAM 3009
L K E GEY + Y+ K ++ NFDN G AM
Sbjct: 773 ------KLHKACRDEITGEYEENIRPCGVGYQCPPGYKCYGGWDGPNDGITNFDNFGLAM 826
Query: 3010 ISLFVVSTFEGWPQLLYVAIDSNEED 3087
+++F T EGW +LY D+ D
Sbjct: 827 LTVFQCVTLEGWTDVLYSIQDAMGSD 852
Score = 94.4 bits (233), Expect = 3e-17
Identities = 75/291 (25%), Positives = 128/291 (43%), Gaps = 39/291 (13%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLAC-KHYPSSRG--FEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE++I L I N ++LA YP S L+ +F +F E V+KI+A
Sbjct: 615 KPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFLVIFTAECVMKILAYGF 674
Query: 3511 -LNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRG 3687
L+ Y+ + WN+ D +VV I +L + + R FRV+R ++L+S
Sbjct: 675 VLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMK---DAFDVKALRAFRVLRPLRLVSGV 731
Query: 3688 EGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFG----KVALDDSTSIHRNN-- 3849
++ +L + +K+ L ++ALL++ + IYA+IG++ F K D+ T + N
Sbjct: 732 PSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKACRDEITGEYEENIR 791
Query: 3850 --------------------------NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDV 3951
NF +F A+L +F+ T E W D++ S D
Sbjct: 792 PCGVGYQCPPGYKCYGGWDGPNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQD---- 847
Query: 3952 RCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
G+++ + YFIS +L +F V+NL + V+ F
Sbjct: 848 -----------------AMGSDWQWMYFISMVILGAFFVMNLILGVLSGEF 881
Score = 79.3 bits (194), Expect = 1e-12
Identities = 82/371 (22%), Positives = 148/371 (39%), Gaps = 48/371 (12%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIY---QPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMG 438
FE+ I +I N + LA+ QP + LL+ + +F VF +E V K+ A
Sbjct: 1665 FEYTIFILIMINTVTLAMKFYNQPL------WYTELLDALNMIFTAVFALEFVFKLAAFR 1718
Query: 439 FMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMS------------IQG----------- 549
F Y +AWN+ DFIIV+ + + S++ ++G
Sbjct: 1719 F----KNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSN 1774
Query: 550 -FDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLEL 726
+ R FRV+R ++L+S ++ +L +++ L ++ALL++ + IYA++G+++
Sbjct: 1775 LISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQV 1834
Query: 727 FCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGP 906
F GK+ +D A
Sbjct: 1835 F-GKI---ALDGGNAITA------------------------------------------ 1848
Query: 907 NNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVN---------------DAVGREWPWIY 1041
NN NF F A+L +F+ + E W ++M + + G + Y
Sbjct: 1849 NN---NFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSDTPGEPCGSSIAYPY 1905
Query: 1042 FVTLVILGSFFVLNLVLGVLSGEF---SKEREKARARGLFQKFREKQQLEEDLKG---YL 1203
F++ +L SF ++NL + V+ F +++ L + R + + D KG +L
Sbjct: 1906 FISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLWSEYDPDAKGRIKHL 1965
Query: 1204 DWITQAEDIEP 1236
D +T I P
Sbjct: 1966 DVVTLLRKISP 1976
Score = 60.1 bits (144), Expect = 6e-07
Identities = 53/269 (19%), Positives = 97/269 (35%), Gaps = 33/269 (12%)
Frame = +1
Query: 1408 VKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGF 1587
V S +F + + Y Q W N+ F +F++E + K+ + F
Sbjct: 1660 VTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRF 1719
Query: 1588 TTYTTSQFNRFDCFVVISSILEFV-----------LVYFDLMKP------------LGVS 1698
Y +N FD +V+ S ++ V + D+++ + ++
Sbjct: 1720 KNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISIN 1779
Query: 1699 VLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF 1878
R R++R+ K+ GMQVFG
Sbjct: 1780 FFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGKIA 1839
Query: 1879 NFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYH-----GIESFGGVGTLG----- 2028
NF TF QA+L +F+ TGE W +M ++ T G
Sbjct: 1840 LDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSDTPGEPCGS 1899
Query: 2029 VIVCIYYIVLFICGNYILLNVFLAIAVDN 2115
I Y+I ++ +++++N+F+A+ +DN
Sbjct: 1900 SIAYPYFISFYVLCSFLIINLFVAVIMDN 1928
Score = 58.5 bits (140), Expect = 2e-06
Identities = 55/238 (23%), Positives = 98/238 (41%), Gaps = 3/238 (1%)
Frame = +1
Query: 2371 CNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKV 2550
C V F ++ + +++ +LA E Q + N Y + FF +FT E+ LK+
Sbjct: 978 CRKAVKSQAFYWLIIVLVFLNTGVLATEHYGQLDWLDNF-QEYTNVFFIGLFTCEMLLKM 1036
Query: 2551 IVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRA 2730
G +G F + FN D VV S+T +L M
Sbjct: 1037 YSLGF---QGYFV-SLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLLRVFKVT 1092
Query: 2731 K---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAEC 2901
K L ++V ++ ++++I +++L+ F+ +FA++G+Q+F G F
Sbjct: 1093 KYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNF------------ 1140
Query: 2902 RGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
DG K NFD A++++F + T E W ++YV I++
Sbjct: 1141 --------DGKEEK----------YRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINA 1180
Score = 39.7 bits (91), Expect = 0.85
Identities = 22/64 (34%), Positives = 36/64 (55%), Gaps = 3/64 (4%)
Frame = +1
Query: 5299 PFSSRPVLRPAEDSRPVDRLIGQSL---GLGRYADARIVGAARREIEEAYSLGEQEIDLA 5469
P+ R + ++ + + LIG L GLG+Y D+ VG A RE+ EA + +E++LA
Sbjct: 2316 PYDQRRLPTSSDMNGLAESLIGGVLAAEGLGKYCDSEFVGTAAREMREALDMTPEEMNLA 2375
Query: 5470 ADSL 5481
A +
Sbjct: 2376 AHQI 2379
>gi|24584554|ref|NP_723953.1| CG4894-PD [Drosophila melanogaster]
gi|22946603|gb|AAN10931.1| CG4894-PD [Drosophila melanogaster]
Length = 2300
Score = 1110 bits (2872), Expect = 0.0
Identities = 559/858 (65%), Positives = 657/858 (76%), Gaps = 21/858 (2%)
Frame = +1
Query: 2254 MTSARPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVS 2433
M +ARPRRMSEV A+ + PIP +S F+ S TN FRVFC+ + NHS F N +L CI+ S
Sbjct: 1298 MITARPRRMSEVNTATKILPIPPGTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCCIMFS 1357
Query: 2434 SAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLD 2613
SAMLAAE+PL+AN N +LN FDYFFT+VFT+E+ LK+I +G V H G+FCR+AFNLLD
Sbjct: 1358 SAMLAAENPLRANDDLNKVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLD 1417
Query: 2614 ILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIM 2793
+LVV VSL S V ++A+S AINRAKGLKHVVQCVIVAVKTIGNI+
Sbjct: 1418 LLVVCVSLISLVSSSNAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIV 1477
Query: 2794 LVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSN 2973
LVT +LQFMFA+IGVQLFKG FF C D SKMT+ EC G Y+ Y+DGD KP ++R WSN
Sbjct: 1478 LVTCLLQFMFAVIGVQLFKGKFFKCTDGSKMTQDECYGTYLVYDDGDVHKPRLREREWSN 1537
Query: 2974 NDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXX 3153
N F+FD+V M++LF VSTFEGWP LLYV+IDSN+E+ GPIHN R VA
Sbjct: 1538 NRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIII 1597
Query: 3154 XXXXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVW 3333
GFVIVTFQNEGE+EY+NC+LDKNQR CIEFALKAKP RRYIP++ +QY+VW
Sbjct: 1598 AFFMVNIFVGFVIVTFQNEGEQEYKNCDLDKNQRNCIEFALKAKPVRRYIPKHGIQYKVW 1657
Query: 3334 WFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVAL 3513
WFVTS +FEY IF++I++NTV+LA K Y + + LD N+IFT VFA E V K+ A
Sbjct: 1658 WFVTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAF 1717
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNP---------------------GGTNLIS 3630
KNY D WNVFD ++V+GSFIDI Y ++ G+NLIS
Sbjct: 1718 RFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLIS 1777
Query: 3631 INFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGK 3810
INFFRLFRVMRLVKLLS+GEGIRTLLWTF+KSFQALPYVALLIVLLFFIYAV+GMQ FGK
Sbjct: 1778 INFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGK 1837
Query: 3811 VALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGG 3990
+ALD +I NNNF +F A+LVLFRSATGEAWQ+IM+SCS + DV+CD SD +
Sbjct: 1838 IALDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSDTPGEP- 1896
Query: 3991 LNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLW 4170
CG++ AYPYFISF++LCSFL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF+RLW
Sbjct: 1897 -----CGSSIAYPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLW 1951
Query: 4171 SEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNAT 4350
SEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNAT
Sbjct: 1952 SEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVLFNAT 2011
Query: 4351 LFALVRTNLKIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYA 4530
LFA+VRT+L I T+GNID+AN +LR+ IK+IWKRT+ LLD+VVPP G +D+VTVGKFYA
Sbjct: 2012 LFAVVRTSLSIKTDGNIDDANSELRATIKQIWKRTNPKLLDQVVPPPGNDDEVTVGKFYA 2071
Query: 4531 TFLIQDYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFN 4710
T+LIQDYFRRFKKRKE E K P + LQAGLRTLHE+ P LKRAISGNL D
Sbjct: 2072 TYLIQDYFRRFKKRKEQEGKEGHP--DSNTVTLQAGLRTLHEVSPALKRAISGNL--DEL 2127
Query: 4711 FDEPEPQHRRPHSLFNNL 4764
EPEP HRR H+LF ++
Sbjct: 2128 DQEPEPMHRRHHTLFGSV 2145
Score = 731 bits (1886), Expect = 0.0
Identities = 375/644 (58%), Positives = 443/644 (68%), Gaps = 5/644 (0%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+R LCI IVEWKPFEFLIL I ANCIALA+Y PYP DS+ N LE +EYVF+V+F
Sbjct: 602 NPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFLVIF 661
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
T ECV+KI+A GF+ H AYLRN WN+LDF IVVIG +ST LS++ FDVKALRAFRV
Sbjct: 662 TAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMKDAFDVKALRAFRV 721
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLRLVSGVPSLQVVLN+IL+AM+PL HIALLVLFVI+IYAIIGLELF GKLH C D
Sbjct: 722 LRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKACRDE 781
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
TG+ +++ PCG ++C P ++C W GPN+GITNFDNFGL
Sbjct: 782 ITGEY-EENIRPCGV-----GYQCPPG---------YKCYGG--WDGPNDGITNFDNFGL 824
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKE 1122
AMLTVFQCV+LEGWTDV+Y + DA+G +W W+YF+++VILG+FFV+NL+LGVLSGEFSKE
Sbjct: 825 AMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKE 884
Query: 1123 REKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEP-----VNEDEQEDEPVAQTXXX 1287
R KA+ RG FQK REKQQ+EEDL+GYLDWITQAEDIEP + D + +P
Sbjct: 885 RNKAKNRGDFQKLREKQQIEEDLRGYLDWITQAEDIEPDAVGGLISDGKGKQP---NEMD 941
Query: 1288 XXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXX 1467
S+W K +++N VKSQ FYW
Sbjct: 942 STENLGEEMPEVQMTESRWRKMKKDFDRVNRRMRRACRKAVKSQAFYWLIIVLVFLNTGV 1001
Query: 1468 XTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSI 1647
+EHYGQ +WLD+FQ N+FF+ LF+ EMLLKMYSLGF Y S FNRFDCFVVI SI
Sbjct: 1002 LATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSI 1061
Query: 1648 LEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXX 1827
E +L +M PLGVSVLR RLLR+FKVTKYW
Sbjct: 1062 TETLLTNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFL 1121
Query: 1828 XXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESF 2007
GMQVFGGKFNF+ ++ K R NFD F QALLTVFQI+TGEDWN VMY GI ++
Sbjct: 1122 FIVIFALLGMQVFGGKFNFDGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAY 1181
Query: 2008 GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLT 2139
GGV + G + CIY+I+LFICGNYILLNVFLAIAVDNLADADSL+
Sbjct: 1182 GGVSSYGALACIYFIILFICGNYILLNVFLAIAVDNLADADSLS 1225
Score = 119 bits (297), Expect = 1e-24
Identities = 90/312 (28%), Positives = 148/312 (46%), Gaps = 9/312 (2%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
N R C + F +IL I + LA P A D N +L +Y F VF
Sbjct: 1331 NRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRANDD--LNKVLNKFDYFFTAVF 1388
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
TIE +LK+++ GF+ H A+ R+A+N+LD ++V + L+S + S +I VK LR RV
Sbjct: 1389 TIELILKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLISLVSSSNAIS--VVKILRVLRV 1446
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLR ++ L+ V+ ++ A+ + +I L+ + ++A+IG++LF GK C D
Sbjct: 1447 LRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKGKFFK-CTD- 1504
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
G +D + G+ D V W +N +FD+
Sbjct: 1505 --GSKMTQD------ECYGTYLVYDDGD------VHKPRLREREW---SNNRFHFDDVAK 1547
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDAVGREWPWI---------YFVTLVILGSFFVLNLVLG 1095
MLT+F + EGW ++Y D+ I Y++ +I+ +FF++N+ +G
Sbjct: 1548 GMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVG 1607
Query: 1096 VLSGEFSKEREK 1131
+ F E E+
Sbjct: 1608 FVIVTFQNEGEQ 1619
Score = 110 bits (274), Expect = 5e-22
Identities = 71/254 (27%), Positives = 126/254 (48%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S+AF ++I +++ +NT LA +HY ++F + N+ F G+F E +LK+ +L
Sbjct: 982 VKSQAFYWLIIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGF 1041
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD VV+GS + N G + ++ R R++R+ K+ +
Sbjct: 1042 QGYFVSLFNRFDCFVVIGSITETLL--TNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLS 1099
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAIL 3879
L+ + + S Q++ + LL+ L I+A++GMQ FG D NF F A+L
Sbjct: 1100 NLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNFDGKEEKYRMNFDCFWQALL 1159
Query: 3880 VLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCS 4059
+F+ TGE W +M + GG++ A YFI F+ +
Sbjct: 1160 TVFQIMTGEDWNAVMYVGINA-------------YGGVSSY---GALACIYFIILFICGN 1203
Query: 4060 FLVINLFVAVIMDN 4101
++++N+F+A+ +DN
Sbjct: 1204 YILLNVFLAIAVDN 1217
Score = 100 bits (250), Expect = 3e-19
Identities = 142/700 (20%), Positives = 252/700 (35%), Gaps = 70/700 (10%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
N +R+ C V+ + F +LI+ ++ N LA D+ + E FI +
Sbjct: 971 NRRMRRACRKAVKSQAFYWLIIVLVFLNTGVLATEH---YGQLDWLDNFQEYTNVFFIGL 1027
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG-FDVKALRAF 576
FT E +LK+ ++GF Y + +N D +V+ + T+L+ + V LR
Sbjct: 1028 FTCEMLLKMYSLGFQ----GYFVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCV 1083
Query: 577 RVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI 756
R+LR ++ SL ++ ++L ++ + + LL+ I+I+A++G+++F
Sbjct: 1084 RLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVF--------- 1134
Query: 757 DPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNF 936
G F + M NFD F
Sbjct: 1135 --------------------GGKFNFDGKEEKYRM--------------------NFDCF 1154
Query: 937 GLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPW-----IYFVTLVILGSFFVLNLVLGVL 1101
A+LTVFQ ++ E W VMY +A G + IYF+ L I G++ +LN+ L +
Sbjct: 1155 WQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIILFICGNYILLNVFLAIA 1214
Query: 1102 SGEFSKEREKARARGLFQKFREKQQLEED-----LKGYLDWITQAEDIEPVNEDEQEDEP 1266
+ + + E Q + + G D ++ D+E D+ ED+
Sbjct: 1215 VDNLADADSLSEVEKEEEPHDESAQKKSHSPTPTIDGMDDHLSIDIDMEQQELDD-EDKM 1273
Query: 1267 VAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXX-----XXXLVKSQT--- 1422
+T AR +R+ ++N + SQT
Sbjct: 1274 DHETLSDEEVREMCEEEEEVDEEGMITARPRRMSEVNTATKILPIPPGTSFFLFSQTNRF 1333
Query: 1423 ---FYWXXXXXXX----------XXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEML 1563
+W ++ L+ + FF +F++E++
Sbjct: 1334 RVFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRANDDLNKVLNKFDYFFTAVFTIELI 1393
Query: 1564 LKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIF 1731
LK+ S GF + S FN D VV S++ V + V +LR R+LR
Sbjct: 1394 LKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLISLVSSSNAISV---VKILRVLRVLRPL 1450
Query: 1732 KVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF----------- 1878
+ G+Q+F GKF
Sbjct: 1451 RAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKGKFFKCTDGSKMTQ 1510
Query: 1879 -----------NFNPQQPKPRA--------NFDTFVQALLTVFQILTGEDWNTVMYHGI- 1998
+ + +P+ R +FD + +LT+F + T E W ++Y I
Sbjct: 1511 DECYGTYLVYDDGDVHKPRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSID 1570
Query: 1999 ---ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
E+ G + IV YYI+ I + ++N+F+ +
Sbjct: 1571 SNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVI 1610
Score = 98.2 bits (243), Expect = 2e-18
Identities = 73/266 (27%), Positives = 114/266 (42%), Gaps = 13/266 (4%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR--NMILNYF 2502
+LF LS N R C +V F +L I + LA P + + N L
Sbjct: 594 ALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKV 653
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXX 2682
+Y F +FT E +K++ +G V H G++ RN +NLLD +V + S L + M
Sbjct: 654 EYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTAL-SQLMKDAFD 712
Query: 2683 XXXXXXXXXXXAINRAKG---LKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKG 2853
+ G L+ V+ ++ A+ + +I L+ + ++AIIG++LF G
Sbjct: 713 VKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSG 772
Query: 2854 TFFLCNDLSKMTEAECRGEY--------IHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAM 3009
L K E GEY + Y+ K ++ NFDN G AM
Sbjct: 773 ------KLHKACRDEITGEYEENIRPCGVGYQCPPGYKCYGGWDGPNDGITNFDNFGLAM 826
Query: 3010 ISLFVVSTFEGWPQLLYVAIDSNEED 3087
+++F T EGW +LY D+ D
Sbjct: 827 LTVFQCVTLEGWTDVLYSIQDAMGSD 852
Score = 94.4 bits (233), Expect = 3e-17
Identities = 75/291 (25%), Positives = 128/291 (43%), Gaps = 39/291 (13%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLAC-KHYPSSRG--FEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE++I L I N ++LA YP S L+ +F +F E V+KI+A
Sbjct: 615 KPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFLVIFTAECVMKILAYGF 674
Query: 3511 -LNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRG 3687
L+ Y+ + WN+ D +VV I +L + + R FRV+R ++L+S
Sbjct: 675 VLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMK---DAFDVKALRAFRVLRPLRLVSGV 731
Query: 3688 EGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFG----KVALDDSTSIHRNN-- 3849
++ +L + +K+ L ++ALL++ + IYA+IG++ F K D+ T + N
Sbjct: 732 PSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKACRDEITGEYEENIR 791
Query: 3850 --------------------------NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDV 3951
NF +F A+L +F+ T E W D++ S D
Sbjct: 792 PCGVGYQCPPGYKCYGGWDGPNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQD---- 847
Query: 3952 RCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
G+++ + YFIS +L +F V+NL + V+ F
Sbjct: 848 -----------------AMGSDWQWMYFISMVILGAFFVMNLILGVLSGEF 881
Score = 79.3 bits (194), Expect = 1e-12
Identities = 82/371 (22%), Positives = 148/371 (39%), Gaps = 48/371 (12%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIY---QPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMG 438
FE+ I +I N + LA+ QP + LL+ + +F VF +E V K+ A
Sbjct: 1665 FEYTIFILIMINTVTLAMKFYNQPL------WYTELLDALNMIFTAVFALEFVFKLAAFR 1718
Query: 439 FMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMS------------IQG----------- 549
F Y +AWN+ DFIIV+ + + S++ ++G
Sbjct: 1719 F----KNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSN 1774
Query: 550 -FDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLEL 726
+ R FRV+R ++L+S ++ +L +++ L ++ALL++ + IYA++G+++
Sbjct: 1775 LISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQV 1834
Query: 727 FCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGP 906
F GK+ +D A
Sbjct: 1835 F-GKI---ALDGGNAITA------------------------------------------ 1848
Query: 907 NNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVN---------------DAVGREWPWIY 1041
NN NF F A+L +F+ + E W ++M + + G + Y
Sbjct: 1849 NN---NFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSDTPGEPCGSSIAYPY 1905
Query: 1042 FVTLVILGSFFVLNLVLGVLSGEF---SKEREKARARGLFQKFREKQQLEEDLKG---YL 1203
F++ +L SF ++NL + V+ F +++ L + R + + D KG +L
Sbjct: 1906 FISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLWSEYDPDAKGRIKHL 1965
Query: 1204 DWITQAEDIEP 1236
D +T I P
Sbjct: 1966 DVVTLLRKISP 1976
Score = 60.1 bits (144), Expect = 6e-07
Identities = 53/269 (19%), Positives = 97/269 (35%), Gaps = 33/269 (12%)
Frame = +1
Query: 1408 VKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGF 1587
V S +F + + Y Q W N+ F +F++E + K+ + F
Sbjct: 1660 VTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRF 1719
Query: 1588 TTYTTSQFNRFDCFVVISSILEFV-----------LVYFDLMKP------------LGVS 1698
Y +N FD +V+ S ++ V + D+++ + ++
Sbjct: 1720 KNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISIN 1779
Query: 1699 VLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF 1878
R R++R+ K+ GMQVFG
Sbjct: 1780 FFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGKIA 1839
Query: 1879 NFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYH-----GIESFGGVGTLG----- 2028
NF TF QA+L +F+ TGE W +M ++ T G
Sbjct: 1840 LDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSDTPGEPCGS 1899
Query: 2029 VIVCIYYIVLFICGNYILLNVFLAIAVDN 2115
I Y+I ++ +++++N+F+A+ +DN
Sbjct: 1900 SIAYPYFISFYVLCSFLIINLFVAVIMDN 1928
Score = 58.5 bits (140), Expect = 2e-06
Identities = 55/238 (23%), Positives = 98/238 (41%), Gaps = 3/238 (1%)
Frame = +1
Query: 2371 CNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKV 2550
C V F ++ + +++ +LA E Q + N Y + FF +FT E+ LK+
Sbjct: 978 CRKAVKSQAFYWLIIVLVFLNTGVLATEHYGQLDWLDNF-QEYTNVFFIGLFTCEMLLKM 1036
Query: 2551 IVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRA 2730
G +G F + FN D VV S+T +L M
Sbjct: 1037 YSLGF---QGYFV-SLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLLRVFKVT 1092
Query: 2731 K---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAEC 2901
K L ++V ++ ++++I +++L+ F+ +FA++G+Q+F G F
Sbjct: 1093 KYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNF------------ 1140
Query: 2902 RGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
DG K NFD A++++F + T E W ++YV I++
Sbjct: 1141 --------DGKEEK----------YRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINA 1180
>gi|24584551|ref|NP_723952.1| CG4894-PC [Drosophila melanogaster]
gi|22946602|gb|AAN10930.1| CG4894-PC [Drosophila melanogaster]
Length = 2552
Score = 1096 bits (2834), Expect = 0.0
Identities = 560/894 (62%), Positives = 658/894 (72%), Gaps = 57/894 (6%)
Frame = +1
Query: 2254 MTSARPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVS 2433
M +ARPRRMSEV A+ + PIP +S F+ S TN FRVFC+ + NHS F N +L CI+ S
Sbjct: 1298 MITARPRRMSEVNTATKILPIPPGTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCCIMFS 1357
Query: 2434 SAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLD 2613
SAMLAAE+PL+AN N +LN FDYFFT+VFT+E+ LK+I +G V H G+FCR+AFNLLD
Sbjct: 1358 SAMLAAENPLRANDDLNKVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLD 1417
Query: 2614 ILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNI- 2790
+LVV VSL S V ++A+S AINRAKGLKHVVQCVIVAVKTIGNI
Sbjct: 1418 LLVVCVSLISLVSSSNAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIV 1477
Query: 2791 -----------------------------------MLVTFMLQFMFAIIGVQLFKGTFFL 2865
MLVT++LQFMFA+IGVQLFKG FF
Sbjct: 1478 LVTCLLQFMFAVIGVQLFKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFK 1537
Query: 2866 CNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGW 3045
C D SKMT+ EC G Y+ Y+DGD KP ++R WSNN F+FD+V M++LF VSTFEGW
Sbjct: 1538 CTDGSKMTQDECYGTYLVYDDGDVHKPRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGW 1597
Query: 3046 PQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIVTFQNEGEREY 3225
P LLYV+IDSN+E+ GPIHN R VA GFVIVTFQNEGE+EY
Sbjct: 1598 PGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNEGEQEY 1657
Query: 3226 ENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLA 3405
+NC+LDKNQR CIEFALKAKP RRYIP++ +QY+VWWFVTS +FEY IF++I++NTV+LA
Sbjct: 1658 KNCDLDKNQRNCIEFALKAKPVRRYIPKHGIQYKVWWFVTSSSFEYTIFILIMINTVTLA 1717
Query: 3406 CKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFID 3585
K Y + + LD N+IFT VFA E V K+ A KNY D WNVFD ++V+GSFID
Sbjct: 1718 MKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFID 1777
Query: 3586 ITYGKLNP---------------------GGTNLISINFFRLFRVMRLVKLLSRGEGIRT 3702
I Y ++ G+NLISINFFRLFRVMRLVKLLS+GEGIRT
Sbjct: 1778 IVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRT 1837
Query: 3703 LLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILV 3882
LLWTF+KSFQALPYVALLIVLLFFIYAV+GMQ FGK+ALD +I NNNF +F A+LV
Sbjct: 1838 LLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGKIALDGGNAITANNNFQTFQQAVLV 1897
Query: 3883 LFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSF 4062
LFRSATGEAWQ+IM+SCS + DV+CD SD + CG++ AYPYFISF++LCSF
Sbjct: 1898 LFRSATGEAWQEIMMSCSAQPDVKCDMNSDTPGEP------CGSSIAYPYFISFYVLCSF 1951
Query: 4063 LVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKIS 4242
L+INLFVAVIMDNFDYLTRDWSILGPHHL+EF+RLWSEYDPDAKGRIKHLDVVTLLRKIS
Sbjct: 1952 LIINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKIS 2011
Query: 4243 PPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNIDEANEQL 4422
PPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFA+VRT+L I T+GNID+AN +L
Sbjct: 2012 PPLGFGKLCPHRMACKRLVSMNMPLNSDGTVLFNATLFAVVRTSLSIKTDGNIDDANSEL 2071
Query: 4423 RSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEMEAKGVLP 4602
R+ IK+IWKRT+ LLD+VVPP G +D+VTVGKFYAT+LIQDYFRRFKKRKE E K P
Sbjct: 2072 RATIKQIWKRTNPKLLDQVVPPPGNDDEVTVGKFYATYLIQDYFRRFKKRKEQEGKEGHP 2131
Query: 4603 AQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDEPEPQHRRPHSLFNNL 4764
+ LQAGLRTLHE+ P LKRAISGNL D EPEP HRR H+LF ++
Sbjct: 2132 --DSNTVTLQAGLRTLHEVSPALKRAISGNL--DELDQEPEPMHRRHHTLFGSV 2181
Score = 731 bits (1886), Expect = 0.0
Identities = 375/644 (58%), Positives = 443/644 (68%), Gaps = 5/644 (0%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+R LCI IVEWKPFEFLIL I ANCIALA+Y PYP DS+ N LE +EYVF+V+F
Sbjct: 602 NPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFLVIF 661
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
T ECV+KI+A GF+ H AYLRN WN+LDF IVVIG +ST LS++ FDVKALRAFRV
Sbjct: 662 TAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMKDAFDVKALRAFRV 721
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLRLVSGVPSLQVVLN+IL+AM+PL HIALLVLFVI+IYAIIGLELF GKLH C D
Sbjct: 722 LRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKACRDE 781
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
TG+ +++ PCG ++C P ++C W GPN+GITNFDNFGL
Sbjct: 782 ITGEY-EENIRPCGV-----GYQCPPG---------YKCYGG--WDGPNDGITNFDNFGL 824
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKE 1122
AMLTVFQCV+LEGWTDV+Y + DA+G +W W+YF+++VILG+FFV+NL+LGVLSGEFSKE
Sbjct: 825 AMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKE 884
Query: 1123 REKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEP-----VNEDEQEDEPVAQTXXX 1287
R KA+ RG FQK REKQQ+EEDL+GYLDWITQAEDIEP + D + +P
Sbjct: 885 RNKAKNRGDFQKLREKQQIEEDLRGYLDWITQAEDIEPDAVGGLISDGKGKQP---NEMD 941
Query: 1288 XXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXX 1467
S+W K +++N VKSQ FYW
Sbjct: 942 STENLGEEMPEVQMTESRWRKMKKDFDRVNRRMRRACRKAVKSQAFYWLIIVLVFLNTGV 1001
Query: 1468 XTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSI 1647
+EHYGQ +WLD+FQ N+FF+ LF+ EMLLKMYSLGF Y S FNRFDCFVVI SI
Sbjct: 1002 LATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSI 1061
Query: 1648 LEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXX 1827
E +L +M PLGVSVLR RLLR+FKVTKYW
Sbjct: 1062 TETLLTNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFL 1121
Query: 1828 XXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESF 2007
GMQVFGGKFNF+ ++ K R NFD F QALLTVFQI+TGEDWN VMY GI ++
Sbjct: 1122 FIVIFALLGMQVFGGKFNFDGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAY 1181
Query: 2008 GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLT 2139
GGV + G + CIY+I+LFICGNYILLNVFLAIAVDNLADADSL+
Sbjct: 1182 GGVSSYGALACIYFIILFICGNYILLNVFLAIAVDNLADADSLS 1225
Score = 115 bits (287), Expect = 2e-23
Identities = 93/334 (27%), Positives = 152/334 (44%), Gaps = 31/334 (9%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
N R C + F +IL I + LA P A D N +L +Y F VF
Sbjct: 1331 NRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRANDD--LNKVLNKFDYFFTAVF 1388
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
TIE +LK+++ GF+ H A+ R+A+N+LD ++V + L+S + S +I VK LR RV
Sbjct: 1389 TIELILKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLISLVSSSNAIS--VVKILRVLRV 1446
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLR ++ L+ V+ ++ A+ + +I L+ + ++A+IG++LF K C+
Sbjct: 1447 LRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLF--KYVVKCVVV 1504
Query: 763 A---------TGQLAQKDPTPCGTDT-EGSAFKCQPSDSLT------------NMGVRWE 876
A L Q G +G FKC +T + V
Sbjct: 1505 AIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKCTDGSKMTQDECYGTYLVYDDGDVHKP 1564
Query: 877 CSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWI------ 1038
W +N +FD+ MLT+F + EGW ++Y D+ I
Sbjct: 1565 RLREREW---SNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPI 1621
Query: 1039 ---YFVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
Y++ +I+ +FF++N+ +G + F E E+
Sbjct: 1622 VAAYYIIYIIIIAFFMVNIFVGFVIVTFQNEGEQ 1655
Score = 110 bits (274), Expect = 5e-22
Identities = 71/254 (27%), Positives = 126/254 (48%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S+AF ++I +++ +NT LA +HY ++F + N+ F G+F E +LK+ +L
Sbjct: 982 VKSQAFYWLIIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGF 1041
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD VV+GS + N G + ++ R R++R+ K+ +
Sbjct: 1042 QGYFVSLFNRFDCFVVIGSITETLL--TNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLS 1099
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAIL 3879
L+ + + S Q++ + LL+ L I+A++GMQ FG D NF F A+L
Sbjct: 1100 NLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNFDGKEEKYRMNFDCFWQALL 1159
Query: 3880 VLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCS 4059
+F+ TGE W +M + GG++ A YFI F+ +
Sbjct: 1160 TVFQIMTGEDWNAVMYVGINA-------------YGGVSSY---GALACIYFIILFICGN 1203
Query: 4060 FLVINLFVAVIMDN 4101
++++N+F+A+ +DN
Sbjct: 1204 YILLNVFLAIAVDN 1217
Score = 98.2 bits (243), Expect = 2e-18
Identities = 73/266 (27%), Positives = 114/266 (42%), Gaps = 13/266 (4%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR--NMILNYF 2502
+LF LS N R C +V F +L I + LA P + + N L
Sbjct: 594 ALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKV 653
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXX 2682
+Y F +FT E +K++ +G V H G++ RN +NLLD +V + S L + M
Sbjct: 654 EYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTAL-SQLMKDAFD 712
Query: 2683 XXXXXXXXXXXAINRAKG---LKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKG 2853
+ G L+ V+ ++ A+ + +I L+ + ++AIIG++LF G
Sbjct: 713 VKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSG 772
Query: 2854 TFFLCNDLSKMTEAECRGEY--------IHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAM 3009
L K E GEY + Y+ K ++ NFDN G AM
Sbjct: 773 ------KLHKACRDEITGEYEENIRPCGVGYQCPPGYKCYGGWDGPNDGITNFDNFGLAM 826
Query: 3010 ISLFVVSTFEGWPQLLYVAIDSNEED 3087
+++F T EGW +LY D+ D
Sbjct: 827 LTVFQCVTLEGWTDVLYSIQDAMGSD 852
Score = 94.4 bits (233), Expect = 3e-17
Identities = 75/291 (25%), Positives = 128/291 (43%), Gaps = 39/291 (13%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLAC-KHYPSSRG--FEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE++I L I N ++LA YP S L+ +F +F E V+KI+A
Sbjct: 615 KPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFLVIFTAECVMKILAYGF 674
Query: 3511 -LNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRG 3687
L+ Y+ + WN+ D +VV I +L + + R FRV+R ++L+S
Sbjct: 675 VLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMK---DAFDVKALRAFRVLRPLRLVSGV 731
Query: 3688 EGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFG----KVALDDSTSIHRNN-- 3849
++ +L + +K+ L ++ALL++ + IYA+IG++ F K D+ T + N
Sbjct: 732 PSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKACRDEITGEYEENIR 791
Query: 3850 --------------------------NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDV 3951
NF +F A+L +F+ T E W D++ S D
Sbjct: 792 PCGVGYQCPPGYKCYGGWDGPNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQD---- 847
Query: 3952 RCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
G+++ + YFIS +L +F V+NL + V+ F
Sbjct: 848 -----------------AMGSDWQWMYFISMVILGAFFVMNLILGVLSGEF 881
Score = 87.0 bits (214), Expect = 5e-15
Identities = 113/541 (20%), Positives = 203/541 (36%), Gaps = 36/541 (6%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
N +R+ C V+ + F +LI+ ++ N LA D+ + E FI +
Sbjct: 971 NRRMRRACRKAVKSQAFYWLIIVLVFLNTGVLATEH---YGQLDWLDNFQEYTNVFFIGL 1027
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG-FDVKALRAF 576
FT E +LK+ ++GF Y + +N D +V+ + T+L+ + V LR
Sbjct: 1028 FTCEMLLKMYSLGFQ----GYFVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCV 1083
Query: 577 RVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI 756
R+LR ++ SL ++ ++L ++ + + LL+ I+I+A++G+++F
Sbjct: 1084 RLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVF--------- 1134
Query: 757 DPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNF 936
G F + M NFD F
Sbjct: 1135 --------------------GGKFNFDGKEEKYRM--------------------NFDCF 1154
Query: 937 GLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPW-----IYFVTLVILGSFFVLNLVLGVL 1101
A+LTVFQ ++ E W VMY +A G + IYF+ L I G++ +LN+ L +
Sbjct: 1155 WQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIILFICGNYILLNVFLAIA 1214
Query: 1102 SGEFSKEREKARARGLFQKFREKQQLEED-----LKGYLDWITQAEDIEPVNEDEQEDEP 1266
+ + + E Q + + G D ++ D+E D+ ED+
Sbjct: 1215 VDNLADADSLSEVEKEEEPHDESAQKKSHSPTPTIDGMDDHLSIDIDMEQQELDD-EDKM 1273
Query: 1267 VAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXX-----XXXLVKSQT--- 1422
+T AR +R+ ++N + SQT
Sbjct: 1274 DHETLSDEEVREMCEEEEEVDEEGMITARPRRMSEVNTATKILPIPPGTSFFLFSQTNRF 1333
Query: 1423 ---FYWXXXXXXX----------XXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEML 1563
+W ++ L+ + FF +F++E++
Sbjct: 1334 RVFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRANDDLNKVLNKFDYFFTAVFTIELI 1393
Query: 1564 LKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIF 1731
LK+ S GF + S FN D VV S++ V +SV++ R+LR+
Sbjct: 1394 LKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLISLV------SSSNAISVVKILRVLRVL 1447
Query: 1732 K 1734
+
Sbjct: 1448 R 1448
Score = 79.3 bits (194), Expect = 1e-12
Identities = 82/371 (22%), Positives = 148/371 (39%), Gaps = 48/371 (12%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIY---QPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMG 438
FE+ I +I N + LA+ QP + LL+ + +F VF +E V K+ A
Sbjct: 1701 FEYTIFILIMINTVTLAMKFYNQPL------WYTELLDALNMIFTAVFALEFVFKLAAFR 1754
Query: 439 FMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMS------------IQG----------- 549
F Y +AWN+ DFIIV+ + + S++ ++G
Sbjct: 1755 F----KNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSN 1810
Query: 550 -FDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLEL 726
+ R FRV+R ++L+S ++ +L +++ L ++ALL++ + IYA++G+++
Sbjct: 1811 LISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQV 1870
Query: 727 FCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGP 906
F GK+ +D A
Sbjct: 1871 F-GKI---ALDGGNAITA------------------------------------------ 1884
Query: 907 NNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVN---------------DAVGREWPWIY 1041
NN NF F A+L +F+ + E W ++M + + G + Y
Sbjct: 1885 NN---NFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSDTPGEPCGSSIAYPY 1941
Query: 1042 FVTLVILGSFFVLNLVLGVLSGEF---SKEREKARARGLFQKFREKQQLEEDLKG---YL 1203
F++ +L SF ++NL + V+ F +++ L + R + + D KG +L
Sbjct: 1942 FISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLWSEYDPDAKGRIKHL 2001
Query: 1204 DWITQAEDIEP 1236
D +T I P
Sbjct: 2002 DVVTLLRKISP 2012
Score = 60.1 bits (144), Expect = 6e-07
Identities = 53/269 (19%), Positives = 97/269 (35%), Gaps = 33/269 (12%)
Frame = +1
Query: 1408 VKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGF 1587
V S +F + + Y Q W N+ F +F++E + K+ + F
Sbjct: 1696 VTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRF 1755
Query: 1588 TTYTTSQFNRFDCFVVISSILEFV-----------LVYFDLMKP------------LGVS 1698
Y +N FD +V+ S ++ V + D+++ + ++
Sbjct: 1756 KNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISIN 1815
Query: 1699 VLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF 1878
R R++R+ K+ GMQVFG
Sbjct: 1816 FFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGKIA 1875
Query: 1879 NFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYH-----GIESFGGVGTLG----- 2028
NF TF QA+L +F+ TGE W +M ++ T G
Sbjct: 1876 LDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSDTPGEPCGS 1935
Query: 2029 VIVCIYYIVLFICGNYILLNVFLAIAVDN 2115
I Y+I ++ +++++N+F+A+ +DN
Sbjct: 1936 SIAYPYFISFYVLCSFLIINLFVAVIMDN 1964
Score = 58.5 bits (140), Expect = 2e-06
Identities = 55/238 (23%), Positives = 98/238 (41%), Gaps = 3/238 (1%)
Frame = +1
Query: 2371 CNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKV 2550
C V F ++ + +++ +LA E Q + N Y + FF +FT E+ LK+
Sbjct: 978 CRKAVKSQAFYWLIIVLVFLNTGVLATEHYGQLDWLDNF-QEYTNVFFIGLFTCEMLLKM 1036
Query: 2551 IVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRA 2730
G +G F + FN D VV S+T +L M
Sbjct: 1037 YSLGF---QGYFV-SLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLLRVFKVT 1092
Query: 2731 K---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAEC 2901
K L ++V ++ ++++I +++L+ F+ +FA++G+Q+F G F
Sbjct: 1093 KYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNF------------ 1140
Query: 2902 RGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
DG K NFD A++++F + T E W ++YV I++
Sbjct: 1141 --------DGKEEK----------YRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINA 1180
Score = 41.2 bits (95), Expect = 0.29
Identities = 21/72 (29%), Positives = 37/72 (51%), Gaps = 4/72 (5%)
Frame = +1
Query: 1906 RANFDTFVQALLTVFQILTGEDWNTVMYHGI----ESFGGVGTLGVIVCIYYIVLFICGN 2073
R +FD + +LT+F + T E W ++Y I E+ G + IV YYI+ I
Sbjct: 1575 RFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIA 1634
Query: 2074 YILLNVFLAIAV 2109
+ ++N+F+ +
Sbjct: 1635 FFMVNIFVGFVI 1646
Score = 39.7 bits (91), Expect = 0.85
Identities = 22/64 (34%), Positives = 36/64 (55%), Gaps = 3/64 (4%)
Frame = +1
Query: 5299 PFSSRPVLRPAEDSRPVDRLIGQSL---GLGRYADARIVGAARREIEEAYSLGEQEIDLA 5469
P+ R + ++ + + LIG L GLG+Y D+ VG A RE+ EA + +E++LA
Sbjct: 2352 PYDQRRLPTSSDMNGLAESLIGGVLAAEGLGKYCDSEFVGTAAREMREALDMTPEEMNLA 2411
Query: 5470 ADSL 5481
A +
Sbjct: 2412 AHQI 2415
>gi|5921703|sp|Q25452|CCAM_MUSDO Muscle calcium channel alpha-1
subunit (MDL-alpha1)
gi|1085178|pir||S41742 calcium channel alpha-1-chain - house fly
gi|470062|emb|CAA83514.1| voltage dependent calcium channel alpha1
subunit [Musca domestica]
Length = 1687
Score = 1085 bits (2806), Expect = 0.0
Identities = 549/880 (62%), Positives = 663/880 (74%), Gaps = 17/880 (1%)
Frame = +1
Query: 2260 SARPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSA 2439
S+ PRR + K IP +S FI SHTN FR+FC+ + NHS F N +L CI+ SSA
Sbjct: 746 SSLPRRNTNTDMDRIKKDIPYGTSFFIFSHTNRFRIFCHRLCNHSNFGNFILCCIMFSSA 805
Query: 2440 MLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDIL 2619
MLAAE+PL+A+++RN++LN FDYFFT+VFT+E+ LK+I +G V H G+FCR+AFNLLD+L
Sbjct: 806 MLAAENPLKADASRNIVLNKFDYFFTAVFTIELVLKLISYGFVLHDGAFCRSAFNLLDLL 865
Query: 2620 VVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLV 2799
VV VSL S ++A+S AINRAKGLKHVVQCVIVAVKTIGNI+LV
Sbjct: 866 VVCVSLISIFFNSNAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLV 925
Query: 2800 TFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNND 2979
T +LQFMFA+IGVQLFKG FF C+D SK+ E++C G Y+ YE+GD KP K+R W NN
Sbjct: 926 TCLLQFMFAVIGVQLFKGKFFSCSDGSKVYESDCHGTYLFYENGDINKPRLKEREWKNNK 985
Query: 2980 FNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXX 3159
F+FD+V AM++LF VSTFEGWP LLYV+IDSN+E+ GPI+N R VA
Sbjct: 986 FHFDDVAKAMLTLFTVSTFEGWPTLLYVSIDSNKENGGPIYNFRPIVAAYYIIYIIIIAF 1045
Query: 3160 XXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWF 3339
GFVIVTFQNEGE+EY+NCELDKNQR CIEFALKAKP RRYIP++ +QY+VWWF
Sbjct: 1046 FMVNIFVGFVIVTFQNEGEQEYKNCELDKNQRNCIEFALKAKPVRRYIPKHSIQYKVWWF 1105
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
VTS +FEY IF++I++NTV+LA K Y + + LD N+IFT VF+ E + K+ A
Sbjct: 1106 VTSSSFEYSIFVLIMINTVTLAMKFYKQPEYYSEILDALNMIFTAVFSLEFIFKLAAFRF 1165
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNP-----------------GGTNLISINFFRL 3648
KNY D WN FD ++V+GSFIDI Y ++ GG+ LISINFFRL
Sbjct: 1166 KNYFGDAWNTFDFIIVLGSFIDIVYSEIKTKEQALATCDGQSCNKAKGGSTLISINFFRL 1225
Query: 3649 FRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDS 3828
FRVMRLVKLLS+GEGIRTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+ L++
Sbjct: 1226 FRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIMLEEG 1285
Query: 3829 TSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRC 4008
TSI RNNNF +FP A+LVLFRSATGEAWQ+IM++CS R+DV+CDP SD + C
Sbjct: 1286 TSIDRNNNFQTFPQAVLVLFRSATGEAWQEIMMACSPRDDVKCDPESDAVNN-------C 1338
Query: 4009 GNNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPD 4188
G++ A+PYFISF++LCSFL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF+RLWSEYDPD
Sbjct: 1339 GSSIAFPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLWSEYDPD 1398
Query: 4189 AKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVR 4368
AKGRIKHLDVVTLLRKISPPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFA+VR
Sbjct: 1399 AKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVLFNATLFAVVR 1458
Query: 4369 TNLKIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQD 4548
L I T+GNIDEAN +LR+ IK+IWKRT+ LLD+VV G +D+VTVGKFYAT+LIQD
Sbjct: 1459 LPLAIKTDGNIDEANAELRATIKQIWKRTNPRLLDQVV-LTGNDDEVTVGKFYATYLIQD 1517
Query: 4549 YFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDEPEP 4728
YFRRFKKRKE E K QT A+ LQAGLRTL + P LKR ISG L D E +P
Sbjct: 1518 YFRRFKKRKEQEGK---CDQTENAVTLQAGLRTLQQNSPALKRTISGYL--DELASEADP 1572
Query: 4729 QHRRPHSLFNNLVHRLSGAGSKSPTEHERIEKGSTLLPFQ 4848
HRR HSLF ++ L + ++ + + + T +P+Q
Sbjct: 1573 MHRRHHSLFGKVMSSLLRHEEITSSKIKHLSRTKT-IPYQ 1611
Score = 723 bits (1865), Expect = 0.0
Identities = 377/644 (58%), Positives = 444/644 (68%), Gaps = 5/644 (0%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+R CI IV+ K FE+ IL I ANC+ALA+Y PYP+ DS+ N +LE IEY+F+V+F
Sbjct: 48 NPLRIFCIKIVDSKLFEYFILLTIFANCVALAVYTPYPSGDSNITNQMLEKIEYIFLVIF 107
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
T ECV+KI+A GF+ H +YLRN WN LDF IVVIG++ST LS + +GFDVKALRAFRV
Sbjct: 108 TSECVMKIIAYGFVLHTGSYLRNGWNFLDFFIVVIGMISTALSNLVKEGFDVKALRAFRV 167
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLRLVSGVPSLQVVLN+IL+AMIPLLHIALLVLFVI+IYAIIGLELF GKLH TC
Sbjct: 168 LRPLRLVSGVPSLQVVLNSILKAMIPLLHIALLVLFVIIIYAIIGLELFSGKLHKTCRHS 227
Query: 763 ATGQLAQ--KDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNF 936
TG+ + CG FKC PS +EC + W GPN+GITNFDNF
Sbjct: 228 NTGEYLNDLDELHACGV-----GFKC-PSG--------YECFDD--WVGPNDGITNFDNF 271
Query: 937 GLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFS 1116
GL+MLTVFQC++LEGWTDV+Y + DA+G W WIYFV++VILG+FFV+NL+LGVLSGEFS
Sbjct: 272 GLSMLTVFQCITLEGWTDVLYSIQDAMGSSWEWIYFVSMVILGAFFVMNLILGVLSGEFS 331
Query: 1117 KEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQ--EDEPVAQTXXXX 1290
KER KA+ RG FQK REKQQ+EEDL+GYLDWITQAEDIEP + D Q ED +
Sbjct: 332 KERTKAKNRGDFQKLREKQQIEEDLRGYLDWITQAEDIEP-DPDAQIIEDCHKNKVKEVV 390
Query: 1291 XXXXXXXXXXXXXXPSKW-AARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXX 1467
W ++ K LE++N VKSQ FYW
Sbjct: 391 SIDNLKDHENETQQTDSWFRSQKKYLERINRRIRRACRKAVKSQAFYWLIILLVFLNTGV 450
Query: 1468 XTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSI 1647
+EHY Q WLD FQ N+FF+ LF+ EM+LKMYSLGF Y S FNRFDCFVVI SI
Sbjct: 451 LATEHYRQPIWLDQFQEYTNIFFIALFTCEMILKMYSLGFQGYFVSLFNRFDCFVVIGSI 510
Query: 1648 LEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXX 1827
E VL +LM PLGVSVLR RLLR+FKVTKYW
Sbjct: 511 SEMVLTSSELMAPLGVSVLRCVRLLRVFKVTKYWHSLSNLVASLLNSIQSIASLLLLLFL 570
Query: 1828 XXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESF 2007
GMQVFGG+F F P++ KPR+NFD+F Q+LLTVFQILTGEDWN VMY GI ++
Sbjct: 571 FIVIFGLLGMQVFGGRFTFKPEEEKPRSNFDSFYQSLLTVFQILTGEDWNVVMYDGIRAY 630
Query: 2008 GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLT 2139
GGV + G++ CIYYI+LFICGNYILLNVFLAIAVDNLADADSL+
Sbjct: 631 GGVFSFGIVACIYYIILFICGNYILLNVFLAIAVDNLADADSLS 674
Score = 141 bits (355), Expect = 2e-31
Identities = 144/658 (21%), Positives = 264/658 (39%), Gaps = 67/658 (10%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR--NMILNYF 2502
+LF L+ N R+FC +V+ F +L I + LA P + + N +L
Sbjct: 40 ALFCLTLKNPLRIFCIKIVDSKLFEYFILLTIFANCVALAVYTPYPSGDSNITNQMLEKI 99
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXX 2682
+Y F +FT E +K+I +G V H GS+ RN +N LD +V + + S L
Sbjct: 100 EYIFLVIFTSECVMKIIAYGFVLHTGSYLRNGWNFLDFFIVVIGMISTALSNLVKEGFDV 159
Query: 2683 XXXXXXXXX--XXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGT 2856
++ L+ V+ ++ A+ + +I L+ + ++AIIG++LF G
Sbjct: 160 KALRAFRVLRPLRLVSGVPSLQVVLNSILKAMIPLLHIALLVLFVIIIYAIIGLELFSG- 218
Query: 2857 FFLCNDLSKMTEAECRGEYIHYED-----GDPTKPVSKKRVWSN----ND--FNFDNVGD 3003
L K GEY++ D G K S + + ND NFDN G
Sbjct: 219 -----KLHKTCRHSNTGEYLNDLDELHACGVGFKCPSGYECFDDWVGPNDGITNFDNFGL 273
Query: 3004 AMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXG 3183
+M+++F T EGW +LY D+ I+ +
Sbjct: 274 SMLTVFQCITLEGWTDVLYSIQDAMGSSWEWIYFVSMVILGAFFVMNLILGVLSGEFSKE 333
Query: 3184 FVIVTFQNEGEREYENCELDKNQRKCIEFALKAKP-------------HRRYIP------ 3306
+ + ++ E +++++ R +++ +A+ H+ +
Sbjct: 334 RTKAKNRGDFQKLREKQQIEEDLRGYLDWITQAEDIEPDPDAQIIEDCHKNKVKEVVSID 393
Query: 3307 -----RNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFT 3471
N Q WF + + +L + + AC+ S+ F + + + T
Sbjct: 394 NLKDHENETQQTDSWFRSQKK-----YLERINRRIRRACRKAVKSQAFYWLIILLVFLNT 448
Query: 3472 GVFAFE--------------------------AVLKIVALNPKNYISDRWNVFDLLVVVG 3573
GV A E +LK+ +L + Y +N FD VV+G
Sbjct: 449 GVLATEHYRQPIWLDQFQEYTNIFFIALFTCEMILKMYSLGFQGYFVSLFNRFDCFVVIG 508
Query: 3574 SFID--ITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYV 3747
S + +T +L + ++ R R++R+ K+ + L+ + + S Q++ +
Sbjct: 509 SISEMVLTSSELMAP----LGVSVLRCVRLLRVFKVTKYWHSLSNLVASLLNSIQSIASL 564
Query: 3748 ALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIML 3927
LL+ L I+ ++GMQ FG +NF SF ++L +F+ TGE W +M
Sbjct: 565 LLLLFLFIVIFGLLGMQVFGGRFTFKPEEEKPRSNFDSFYQSLLTVFQILTGEDWNVVMY 624
Query: 3928 SCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDN 4101
+ +R GG+ A Y+I F+ +++++N+F+A+ +DN
Sbjct: 625 -----DGIRA--------YGGVFSF---GIVACIYYIILFICGNYILLNVFLAIAVDN 666
Score = 120 bits (302), Expect = 3e-25
Identities = 91/312 (29%), Positives = 149/312 (47%), Gaps = 9/312 (2%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
N R C + F IL I + LA P A S +N +L +Y F VF
Sbjct: 777 NRFRIFCHRLCNHSNFGNFILCCIMFSSAMLAAENPLKADAS--RNIVLNKFDYFFTAVF 834
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
TIE VLK+++ GF+ H A+ R+A+N+LD ++V + L+S + +I VK LR RV
Sbjct: 835 TIELVLKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLISIFFNSNAIS--VVKILRVLRV 892
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLR ++ L+ V+ ++ A+ + +I L+ + ++A+IG++LF GK S C D
Sbjct: 893 LRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKGKFFS-CSD- 950
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
G + +D G+ + D + W N +FD+
Sbjct: 951 --GSKVYE------SDCHGTYLFYENGD------INKPRLKEREW---KNNKFHFDDVAK 993
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDAVGREWPWI---------YFVTLVILGSFFVLNLVLG 1095
AMLT+F + EGW ++Y D+ I Y++ +I+ +FF++N+ +G
Sbjct: 994 AMLTLFTVSTFEGWPTLLYVSIDSNKENGGPIYNFRPIVAAYYIIYIIIIAFFMVNIFVG 1053
Query: 1096 VLSGEFSKEREK 1131
+ F E E+
Sbjct: 1054 FVIVTFQNEGEQ 1065
Score = 98.2 bits (243), Expect = 2e-18
Identities = 81/297 (27%), Positives = 131/297 (43%), Gaps = 42/297 (14%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLAC-KHYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA 3510
V S+ FEY I L I N V+LA YPS S L+ IF +F E V+KI+A
Sbjct: 58 VDSKLFEYFILLTIFANCVALAVYTPYPSGDSNITNQMLEKIEYIFLVIFTSECVMKIIA 117
Query: 3511 ----LNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLL 3678
L+ +Y+ + WN D +VV I L G + R FRV+R ++L+
Sbjct: 118 YGFVLHTGSYLRNGWNFLDFFIVVIGMISTALSNLVKEG---FDVKALRAFRVLRPLRLV 174
Query: 3679 SRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVA-----------LD 3822
S ++ +L + +K+ L ++ALL++ + IYA+IG++ F GK+ L+
Sbjct: 175 SGVPSLQVVLNSILKAMIPLLHIALLVLFVIIIYAIIGLELFSGKLHKTCRHSNTGEYLN 234
Query: 3823 DSTSIHRNN-----------------------NFHSFPAAILVLFRSATGEAWQDIMLSC 3933
D +H NF +F ++L +F+ T E W D++ S
Sbjct: 235 DLDELHACGVGFKCPSGYECFDDWVGPNDGITNFDNFGLSMLTVFQCITLEGWTDVLYSI 294
Query: 3934 SDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
D G+++ + YF+S +L +F V+NL + V+ F
Sbjct: 295 QD---------------------AMGSSWEWIYFVSMVILGAFFVMNLILGVLSGEF 330
Score = 77.4 bits (189), Expect = 4e-12
Identities = 81/370 (21%), Positives = 144/370 (38%), Gaps = 47/370 (12%)
Frame = +1
Query: 268 FEFLILFMICANCIALAI-YQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFM 444
FE+ I +I N + LA+ + P +Y + +L+ + +F VF++E + K+ A F
Sbjct: 1111 FEYSIFVLIMINTVTLAMKFYKQP----EYYSEILDALNMIFTAVFSLEFIFKLAAFRF- 1165
Query: 445 FHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--------------------FDVKA 564
Y +AWN DFIIV+ + + S++ + +
Sbjct: 1166 ---KNYFGDAWNTFDFIIVLGSFIDIVYSEIKTKEQALATCDGQSCNKAKGGSTLISINF 1222
Query: 565 LRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKL- 741
R FRV+R ++L+S ++ +L +++ L ++ALL++ + IYA+IG+++F GK+
Sbjct: 1223 FRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKIM 1281
Query: 742 --HSTCID-----------------PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMG 864
T ID ATG+ Q+ C + KC P N
Sbjct: 1282 LEEGTSIDRNNNFQTFPQAVLVLFRSATGEAWQEIMMACSPRDD---VKCDPESDAVN-- 1336
Query: 865 VRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYF 1044
C S+ +P YF
Sbjct: 1337 ---NCGSSIAFP----------------------------------------------YF 1347
Query: 1045 VTLVILGSFFVLNLVLGVLSGEF---SKEREKARARGLFQKFREKQQLEEDLKG---YLD 1206
++ +L SF ++NL + V+ F +++ L + R + + D KG +LD
Sbjct: 1348 ISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLWSEYDPDAKGRIKHLD 1407
Query: 1207 WITQAEDIEP 1236
+T I P
Sbjct: 1408 VVTLLRKISP 1417
Score = 63.5 bits (153), Expect = 6e-08
Identities = 61/274 (22%), Positives = 97/274 (35%), Gaps = 38/274 (13%)
Frame = +1
Query: 1408 VKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGF 1587
V S +F + + Y Q E+ N+ F +FS+E + K+ + F
Sbjct: 1106 VTSSSFEYSIFVLIMINTVTLAMKFYKQPEYYSEILDALNMIFTAVFSLEFIFKLAAFRF 1165
Query: 1588 TTYTTSQFNRFDCFVVISSILEFVLVYFDLM---------------KPLGVSVLRSARLL 1722
Y +N FD +V+ S ++ +VY ++ K G S L S
Sbjct: 1166 KNYFGDAWNTFDFIIVLGSFID--IVYSEIKTKEQALATCDGQSCNKAKGGSTLISINFF 1223
Query: 1723 RIFKV--------------TKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQ 1860
R+F+V T WT GMQ
Sbjct: 1224 RLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVI--------GMQ 1275
Query: 1861 VFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYH---------GIESFGG 2013
VFG NF TF QA+L +F+ TGE W +M ES
Sbjct: 1276 VFGKIMLEEGTSIDRNNNFQTFPQAVLVLFRSATGEAWQEIMMACSPRDDVKCDPESDAV 1335
Query: 2014 VGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDN 2115
I Y+I ++ +++++N+F+A+ +DN
Sbjct: 1336 NNCGSSIAFPYFISFYVLCSFLIINLFVAVIMDN 1369
Score = 58.5 bits (140), Expect = 2e-06
Identities = 54/231 (23%), Positives = 89/231 (38%), Gaps = 38/231 (16%)
Frame = +1
Query: 1531 FFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVS 1698
FF +F++E++LK+ S GF + S FN D VV S++ ++F+ V
Sbjct: 829 FFTAVFTIELVLKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLIS---IFFNSNAISVVK 885
Query: 1699 VLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF 1878
+LR R+LR + G+Q+F GKF
Sbjct: 886 ILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKGKF 945
Query: 1879 ------------------------NFNPQQPKPRA------NFDTFVQALLTVFQILTGE 1968
+ N + K R +FD +A+LT+F + T E
Sbjct: 946 FSCSDGSKVYESDCHGTYLFYENGDINKPRLKEREWKNNKFHFDDVAKAMLTLFTVSTFE 1005
Query: 1969 DWNTVMYHGI----ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
W T++Y I E+ G + IV YYI+ I + ++N+F+ +
Sbjct: 1006 GWPTLLYVSIDSNKENGGPIYNFRPIVAAYYIIYIIIIAFFMVNIFVGFVI 1056
>gi|740990|prf||2006265A Ca channel:SUBUNIT=alpha1
Length = 1688
Score = 1082 bits (2798), Expect = 0.0
Identities = 548/880 (62%), Positives = 662/880 (74%), Gaps = 17/880 (1%)
Frame = +1
Query: 2260 SARPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSA 2439
S+ PRR + K IP +S FI SHTN FR+FC+ + NHS F N +L CI+ SSA
Sbjct: 747 SSLPRRNTNTDMDRIKKDIPYGTSFFIFSHTNRFRIFCHRLCNHSNFGNFILCCIMFSSA 806
Query: 2440 MLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDIL 2619
MLAAE+PL+A+++RN++LN FD FFT+VFT+E+ LK+I +G V H G+FCR+AFNLLD+L
Sbjct: 807 MLAAENPLKADASRNIVLNKFDVFFTAVFTIELVLKLISYGFVLHDGAFCRSAFNLLDLL 866
Query: 2620 VVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLV 2799
VV VSL S ++A+S AINRAKGLKHVVQCVIVAVKTIGNI+LV
Sbjct: 867 VVCVSLISIFFNSNAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLV 926
Query: 2800 TFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNND 2979
T +LQFMFA+IGVQLFKG FF C+D SK+ E++C G Y+ YE+GD KP K+R W NN
Sbjct: 927 TCLLQFMFAVIGVQLFKGKFFSCSDGSKVYESDCHGTYLFYENGDINKPRLKEREWKNNK 986
Query: 2980 FNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXX 3159
F+FD+V AM++LF VSTFEGWP LLYV+IDSN+E+ GPI+N R VA
Sbjct: 987 FHFDDVAKAMLTLFTVSTFEGWPTLLYVSIDSNKENGGPIYNFRPIVAAYYIIYIIIIAF 1046
Query: 3160 XXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWF 3339
GFVIVTFQNEGE+EY+NCELDKNQR CIEFALKAKP RRYIP++ +QY+VWWF
Sbjct: 1047 FMVNIFVGFVIVTFQNEGEQEYKNCELDKNQRNCIEFALKAKPVRRYIPKHSIQYKVWWF 1106
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
VTS +FEY IF++I++NTV+LA K Y + + LD N+IFT VF+ E + K+ A
Sbjct: 1107 VTSSSFEYSIFVLIMINTVTLAMKFYKQPEYYSEILDALNMIFTAVFSLEFIFKLAAFRF 1166
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNP-----------------GGTNLISINFFRL 3648
KNY D WN FD ++V+GSFIDI Y ++ GG+ LISINFFRL
Sbjct: 1167 KNYFGDAWNTFDFIIVLGSFIDIVYSEIKTKEQALATCDGQSCNKAKGGSTLISINFFRL 1226
Query: 3649 FRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDS 3828
FRVMRLVKLLS+GEGIRTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+ L++
Sbjct: 1227 FRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIMLEEG 1286
Query: 3829 TSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRC 4008
TSI RNNNF +FP A+LVLFRSATGEAWQ+IM++CS R+DV+CDP SD + C
Sbjct: 1287 TSIDRNNNFQTFPQAVLVLFRSATGEAWQEIMMACSPRDDVKCDPESDAVNN-------C 1339
Query: 4009 GNNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPD 4188
G++ A+PYFISF++LCSFL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF+RLWSEYDPD
Sbjct: 1340 GSSIAFPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLWSEYDPD 1399
Query: 4189 AKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVR 4368
AKGRIKHLDVVTLLRKISPPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFA+VR
Sbjct: 1400 AKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVLFNATLFAVVR 1459
Query: 4369 TNLKIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQD 4548
L I T+GNIDEAN +LR+ IK+IWKRT+ LLD+VV G +D+VTVGKFYAT+LIQD
Sbjct: 1460 LPLAIKTDGNIDEANAELRATIKQIWKRTNPRLLDQVV-LTGNDDEVTVGKFYATYLIQD 1518
Query: 4549 YFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDEPEP 4728
YFRRFKKRKE E K QT A+ LQAGLRTL + P LKR ISG L D E +P
Sbjct: 1519 YFRRFKKRKEQEGK---CDQTENAVTLQAGLRTLQQNSPALKRTISGYL--DELASEADP 1573
Query: 4729 QHRRPHSLFNNLVHRLSGAGSKSPTEHERIEKGSTLLPFQ 4848
HRR HSLF ++ L + ++ + + + T +P+Q
Sbjct: 1574 MHRRHHSLFGKVMSSLLRHEEITSSKIKHLSRTKT-IPYQ 1612
Score = 709 bits (1831), Expect = 0.0
Identities = 377/645 (58%), Positives = 442/645 (68%), Gaps = 6/645 (0%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+R CI IV+ K FE IL I ANC+ALA+Y P P+ DS+ N +LE IEY+F+V+F
Sbjct: 48 NPLRIFCIKIVDSKLFEVFILLTIFANCVALAVYTPVPSGDSNITNQMLEKIEYIFLVIF 107
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
T ECV+KI+A GF+ H +YLRN WN LDF IVVIG++ST LS + +GFDVKALRAFRV
Sbjct: 108 TSECVMKIIAYGFVLHTGSYLRNGWNFLDFFIVVIGMISTALSNLVKEGFDVKALRAFRV 167
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLRLVSGVPSLQVVLN+IL+AMIPLLHIALLVLFVI+I AIIGLELF GKLH TC
Sbjct: 168 LRPLRLVSGVPSLQVVLNSILKAMIPLLHIALLVLFVIIIVAIIGLELFSGKLHKTCRHS 227
Query: 763 ATGQLAQ--KDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNF 936
TG+ + CG FKC PS GV EC + W GPN+GITNFDNF
Sbjct: 228 NTGEYLNDLDELHACGV-----GFKC-PS------GV--ECFDD--WVGPNDGITNFDNF 271
Query: 937 GLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFS 1116
GL+MLTVFQC++LEGWTDV+Y + DA+G W WIYFV++VILG+FFV+NL+LGVLSGEFS
Sbjct: 272 GLSMLTVFQCITLEGWTDVLYSIQDAMGSSWEWIYFVSMVILGAFFVMNLILGVLSGEFS 331
Query: 1117 KEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQ--EDEPVAQTXXXX 1290
KER KA+ RG FQK REKQQ+EEDL+GYLDWITQAEDIEP + D Q ED +
Sbjct: 332 KERTKAKNRGDFQKLREKQQIEEDLRGYLDWITQAEDIEP-DPDAQIIEDCHKNKVKEVV 390
Query: 1291 XXXXXXXXXXXXXXPSKW-AARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXX 1467
W ++ K LE++N VKSQ FYW
Sbjct: 391 SIDNLKDHENETQQTDSWFRSQKKYLERINRRIRRACRKAVKSQAFYWLIILLVFLNTGV 450
Query: 1468 XTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSI 1647
+EHY Q WLD FQ N+FF+ LF+ EM+LKMYSLGF Y S FNRFDCFVVI SI
Sbjct: 451 LATEHYRQPIWLDQFQEYTNIFFIALFTCEMILKMYSLGFQGYFVSLFNRFDCFVVIGSI 510
Query: 1648 LEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYW-TXXXXXXXXXXXXXXXXXXXXXXXX 1824
E VL +LM PLGVSVLR RLLR+FKVTKYW
Sbjct: 511 SEMVLTSSELMAPLGVSVLRCVRLLRVFKVTKYWHHSLSNLVASLLNSIQSIASLLLLLF 570
Query: 1825 XXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIES 2004
GMQVFGG+F F P++ KPR+NFD+F Q+LLTVFQILTGEDWN VMY GI +
Sbjct: 571 LFIVIFGLLGMQVFGGRFTFKPEEEKPRSNFDSFYQSLLTVFQILTGEDWNVVMYDGIRA 630
Query: 2005 FGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLT 2139
+GGV + G++ CIYYI+LFICGNYILLNVFLAIAVDNLADADSL+
Sbjct: 631 YGGVFSFGIVACIYYIILFICGNYILLNVFLAIAVDNLADADSLS 675
Score = 136 bits (343), Expect = 5e-30
Identities = 145/659 (22%), Positives = 263/659 (39%), Gaps = 68/659 (10%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR--NMILNYF 2502
+LF L+ N R+FC +V+ F +L I + LA P+ + + N +L
Sbjct: 40 ALFCLTLKNPLRIFCIKIVDSKLFEVFILLTIFANCVALAVYTPVPSGDSNITNQMLEKI 99
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXX 2682
+Y F +FT E +K+I +G V H GS+ RN +N LD +V + + S L
Sbjct: 100 EYIFLVIFTSECVMKIIAYGFVLHTGSYLRNGWNFLDFFIVVIGMISTALSNLVKEGFDV 159
Query: 2683 XXXXXXXXX--XXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGT 2856
++ L+ V+ ++ A+ + +I L+ + + AIIG++LF G
Sbjct: 160 KALRAFRVLRPLRLVSGVPSLQVVLNSILKAMIPLLHIALLVLFVIIIVAIIGLELFSG- 218
Query: 2857 FFLCNDLSKMTEAECRGEYIHYED-----GDPTKPVSKKRVWSN----ND--FNFDNVGD 3003
L K GEY++ D G K S + + ND NFDN G
Sbjct: 219 -----KLHKTCRHSNTGEYLNDLDELHACGVGFKCPSGVECFDDWVGPNDGITNFDNFGL 273
Query: 3004 AMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXG 3183
+M+++F T EGW +LY D+ I+ +
Sbjct: 274 SMLTVFQCITLEGWTDVLYSIQDAMGSSWEWIYFVSMVILGAFFVMNLILGVLSGEFSKE 333
Query: 3184 FVIVTFQNEGEREYENCELDKNQRKCIEFALKAKP-------------HRRYIP------ 3306
+ + ++ E +++++ R +++ +A+ H+ +
Sbjct: 334 RTKAKNRGDFQKLREKQQIEEDLRGYLDWITQAEDIEPDPDAQIIEDCHKNKVKEVVSID 393
Query: 3307 -----RNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFT 3471
N Q WF + + +L + + AC+ S+ F + + + T
Sbjct: 394 NLKDHENETQQTDSWFRSQKK-----YLERINRRIRRACRKAVKSQAFYWLIILLVFLNT 448
Query: 3472 GVFAFE--------------------------AVLKIVALNPKNYISDRWNVFDLLVVVG 3573
GV A E +LK+ +L + Y +N FD VV+G
Sbjct: 449 GVLATEHYRQPIWLDQFQEYTNIFFIALFTCEMILKMYSLGFQGYFVSLFNRFDCFVVIG 508
Query: 3574 SFIDITYGK---LNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPY 3744
S ++ + P G ++ + RL RV ++ K + L+ + + S Q++
Sbjct: 509 SISEMVLTSSELMAPLGVSV--LRCVRLLRVFKVTKYWH--HSLSNLVASLLNSIQSIAS 564
Query: 3745 VALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIM 3924
+ LL+ L I+ ++GMQ FG +NF SF ++L +F+ TGE W +M
Sbjct: 565 LLLLLFLFIVIFGLLGMQVFGGRFTFKPEEEKPRSNFDSFYQSLLTVFQILTGEDWNVVM 624
Query: 3925 LSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDN 4101
+ +R GG+ A Y+I F+ +++++N+F+A+ +DN
Sbjct: 625 Y-----DGIRA--------YGGVFSF---GIVACIYYIILFICGNYILLNVFLAIAVDN 667
Score = 117 bits (294), Expect = 2e-24
Identities = 90/312 (28%), Positives = 148/312 (46%), Gaps = 9/312 (2%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
N R C + F IL I + LA P A S +N +L + F VF
Sbjct: 778 NRFRIFCHRLCNHSNFGNFILCCIMFSSAMLAAENPLKADAS--RNIVLNKFDVFFTAVF 835
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
TIE VLK+++ GF+ H A+ R+A+N+LD ++V + L+S + +I VK LR RV
Sbjct: 836 TIELVLKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLISIFFNSNAIS--VVKILRVLRV 893
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLR ++ L+ V+ ++ A+ + +I L+ + ++A+IG++LF GK S C D
Sbjct: 894 LRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKGKFFS-CSD- 951
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
G + +D G+ + D + W N +FD+
Sbjct: 952 --GSKVYE------SDCHGTYLFYENGD------INKPRLKEREW---KNNKFHFDDVAK 994
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDAVGREWPWI---------YFVTLVILGSFFVLNLVLG 1095
AMLT+F + EGW ++Y D+ I Y++ +I+ +FF++N+ +G
Sbjct: 995 AMLTLFTVSTFEGWPTLLYVSIDSNKENGGPIYNFRPIVAAYYIIYIIIIAFFMVNIFVG 1054
Query: 1096 VLSGEFSKEREK 1131
+ F E E+
Sbjct: 1055 FVIVTFQNEGEQ 1066
Score = 89.0 bits (219), Expect = 1e-15
Identities = 77/298 (25%), Positives = 129/298 (42%), Gaps = 43/298 (14%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDF----LDVFNLIFTGVFAFEAVLKIV 3507
V S+ FE I L I N V+LA + P G + L+ IF +F E V+KI+
Sbjct: 58 VDSKLFEVFILLTIFANCVALAV-YTPVPSGDSNITNQMLEKIEYIFLVIFTSECVMKII 116
Query: 3508 A----LNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKL 3675
A L+ +Y+ + WN D +VV I L G + R FRV+R ++L
Sbjct: 117 AYGFVLHTGSYLRNGWNFLDFFIVVIGMISTALSNLVKEG---FDVKALRAFRVLRPLRL 173
Query: 3676 LSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVA-----------L 3819
+S ++ +L + +K+ L ++ALL++ + I A+IG++ F GK+ L
Sbjct: 174 VSGVPSLQVVLNSILKAMIPLLHIALLVLFVIIIVAIIGLELFSGKLHKTCRHSNTGEYL 233
Query: 3820 DDSTSIHRNN-----------------------NFHSFPAAILVLFRSATGEAWQDIMLS 3930
+D +H NF +F ++L +F+ T E W D++ S
Sbjct: 234 NDLDELHACGVGFKCPSGVECFDDWVGPNDGITNFDNFGLSMLTVFQCITLEGWTDVLYS 293
Query: 3931 CSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
D G+++ + YF+S +L +F V+NL + V+ F
Sbjct: 294 IQD---------------------AMGSSWEWIYFVSMVILGAFFVMNLILGVLSGEF 330
Score = 77.4 bits (189), Expect = 4e-12
Identities = 81/370 (21%), Positives = 144/370 (38%), Gaps = 47/370 (12%)
Frame = +1
Query: 268 FEFLILFMICANCIALAI-YQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFM 444
FE+ I +I N + LA+ + P +Y + +L+ + +F VF++E + K+ A F
Sbjct: 1112 FEYSIFVLIMINTVTLAMKFYKQP----EYYSEILDALNMIFTAVFSLEFIFKLAAFRF- 1166
Query: 445 FHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--------------------FDVKA 564
Y +AWN DFIIV+ + + S++ + +
Sbjct: 1167 ---KNYFGDAWNTFDFIIVLGSFIDIVYSEIKTKEQALATCDGQSCNKAKGGSTLISINF 1223
Query: 565 LRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKL- 741
R FRV+R ++L+S ++ +L +++ L ++ALL++ + IYA+IG+++F GK+
Sbjct: 1224 FRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKIM 1282
Query: 742 --HSTCID-----------------PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMG 864
T ID ATG+ Q+ C + KC P N
Sbjct: 1283 LEEGTSIDRNNNFQTFPQAVLVLFRSATGEAWQEIMMACSPRDD---VKCDPESDAVN-- 1337
Query: 865 VRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYF 1044
C S+ +P YF
Sbjct: 1338 ---NCGSSIAFP----------------------------------------------YF 1348
Query: 1045 VTLVILGSFFVLNLVLGVLSGEF---SKEREKARARGLFQKFREKQQLEEDLKG---YLD 1206
++ +L SF ++NL + V+ F +++ L + R + + D KG +LD
Sbjct: 1349 ISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLWSEYDPDAKGRIKHLD 1408
Query: 1207 WITQAEDIEP 1236
+T I P
Sbjct: 1409 VVTLLRKISP 1418
Score = 74.3 bits (181), Expect = 3e-11
Identities = 79/341 (23%), Positives = 143/341 (41%), Gaps = 12/341 (3%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIY---QP-YPAQDSDYKNTLLETIEYV 387
N IR+ C V+ + F +LI+ ++ N LA QP + Q +Y N
Sbjct: 420 NRRIRRACRKAVKSQAFYWLIILLVFLNTGVLATEHYRQPIWLDQFQEYTNIF------- 472
Query: 388 FIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG-FDVKA 564
FI +FT E +LK+ ++GF Y + +N D +V+ + +L+ + V
Sbjct: 473 FIALFTCEMILKMYSLGFQ----GYFVSLFNRFDCFVVIGSISEMVLTSSELMAPLGVSV 528
Query: 565 LRAFRVLRPLRLVS-GVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKL 741
LR R+LR ++ SL ++ ++L ++ + + LL+ I+I+ ++G+++F G+
Sbjct: 529 LRCVRLLRVFKVTKYWHHSLSNLVASLLNSIQSIASLLLLLFLFIVIFGLLGMQVFGGRF 588
Query: 742 HSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGIT 921
T P +
Sbjct: 589 -------------------------------------------------TFKPEEEKPRS 599
Query: 922 NFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPW-----IYFVTLVILGSFFVLNL 1086
NFD+F ++LTVFQ ++ E W VMY A G + + IY++ L I G++ +LN+
Sbjct: 600 NFDSFYQSLLTVFQILTGEDWNVVMYDGIRAYGGVFSFGIVACIYYIILFICGNYILLNV 659
Query: 1087 VLGVLSGEFSKEREKARARGLFQKFREKQ-QLEEDLKGYLD 1206
L + + A + +K E Q QL+ +K ++
Sbjct: 660 FLAIAVDNLA----DADSLSTIEKEDESQIQLDNQIKNEME 696
Score = 63.5 bits (153), Expect = 6e-08
Identities = 61/274 (22%), Positives = 97/274 (35%), Gaps = 38/274 (13%)
Frame = +1
Query: 1408 VKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGF 1587
V S +F + + Y Q E+ N+ F +FS+E + K+ + F
Sbjct: 1107 VTSSSFEYSIFVLIMINTVTLAMKFYKQPEYYSEILDALNMIFTAVFSLEFIFKLAAFRF 1166
Query: 1588 TTYTTSQFNRFDCFVVISSILEFVLVYFDLM---------------KPLGVSVLRSARLL 1722
Y +N FD +V+ S ++ +VY ++ K G S L S
Sbjct: 1167 KNYFGDAWNTFDFIIVLGSFID--IVYSEIKTKEQALATCDGQSCNKAKGGSTLISINFF 1224
Query: 1723 RIFKV--------------TKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQ 1860
R+F+V T WT GMQ
Sbjct: 1225 RLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVI--------GMQ 1276
Query: 1861 VFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYH---------GIESFGG 2013
VFG NF TF QA+L +F+ TGE W +M ES
Sbjct: 1277 VFGKIMLEEGTSIDRNNNFQTFPQAVLVLFRSATGEAWQEIMMACSPRDDVKCDPESDAV 1336
Query: 2014 VGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDN 2115
I Y+I ++ +++++N+F+A+ +DN
Sbjct: 1337 NNCGSSIAFPYFISFYVLCSFLIINLFVAVIMDN 1370
Score = 59.3 bits (142), Expect = 1e-06
Identities = 54/233 (23%), Positives = 91/233 (38%), Gaps = 38/233 (16%)
Frame = +1
Query: 1525 NLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLG 1692
++FF +F++E++LK+ S GF + S FN D VV S++ ++F+
Sbjct: 828 DVFFTAVFTIELVLKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLIS---IFFNSNAISV 884
Query: 1693 VSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGG 1872
V +LR R+LR + G+Q+F G
Sbjct: 885 VKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKG 944
Query: 1873 KF------------------------NFNPQQPKPRA------NFDTFVQALLTVFQILT 1962
KF + N + K R +FD +A+LT+F + T
Sbjct: 945 KFFSCSDGSKVYESDCHGTYLFYENGDINKPRLKEREWKNNKFHFDDVAKAMLTLFTVST 1004
Query: 1963 GEDWNTVMYHGI----ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
E W T++Y I E+ G + IV YYI+ I + ++N+F+ +
Sbjct: 1005 FEGWPTLLYVSIDSNKENGGPIYNFRPIVAAYYIIYIIIIAFFMVNIFVGFVI 1057
>gi|25146677|ref|NP_741732.1| UNCoordinated locomotion UNC-2,
voltage-gated Calcium Channel Alpha subunit (unc-2)
[Caenorhabditis elegans]
Length = 1908
Score = 1079 bits (2791), Expect = 0.0
Identities = 663/1698 (39%), Positives = 902/1698 (53%), Gaps = 105/1698 (6%)
Frame = +1
Query: 325 QPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVV 504
Q P D + LE E F+ +F +ECVLK++A GF H +YLR+ WNI+DFI+VV
Sbjct: 3 QHLPKNDKKALSEWLERTEPYFMGIFCLECVLKVIAFGFALHKGSYLRSGWNIMDFIVVV 62
Query: 505 IGLVS-------TILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPL 663
G+V+ T + + D++ LRA RVLRPL+LVSG+PSLQVVL +IL AM PL
Sbjct: 63 SGVVTMLPFSPATQTANQPVDSVDLRTLRAVRVLRPLKLVSGIPSLQVVLKSILCAMAPL 122
Query: 664 LHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQL--AQKDPTPCGTDTEGSAFKCQ 837
L I LLVLF I+I+AIIGLE + G HS C + G++ + P PC T
Sbjct: 123 LQIGLLVLFAIIIFAIIGLEFYSGAFHSACYNER-GEIENVSERPMPCTNKT-------- 173
Query: 838 PSDSLTNMGVRWECSSNTT-----WPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYW 1002
+ MGV + C T W GPN GIT+FDN G AM+TVFQC+++EGWT VMY+
Sbjct: 174 -----SPMGV-YNCDVKGTTCLQKWIGPNYGITSFDNIGFAMITVFQCITMEGWTTVMYY 227
Query: 1003 VNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQQLE 1182
ND++G + W YF+ L++LGSFF+LNLVLGVLSGEF+KERE+ R F K R +QQ+E
Sbjct: 228 TNDSLGSTYNWAYFIPLIVLGSFFMLNLVLGVLSGEFAKERERVENRREFLKLRRQQQIE 287
Query: 1183 EDLKGYLDWITQAEDIEPVNEDEQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKW------ 1344
+L GYL+WI AE++ + E+E A ++
Sbjct: 288 RELNGYLEWILTAEEVILKEDRTTEEEKAAIMEARRRAANKKLKQASKQQSTETEEDFEE 347
Query: 1345 ------------AARMKR-----LEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXT 1473
A R KR + K +VK+Q FYW
Sbjct: 348 DEDEMEEEYVDEAERKKRGCCHSVGKFIKQLRIQIRIMVKTQIFYWSVITLVFLNTCCVA 407
Query: 1474 SEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILE 1653
SEHYGQ +W F A F+ +F +EMLLK++++G TY S+FNRFDC V++ S E
Sbjct: 408 SEHYGQPQWFTDFLKYAEFVFLGIFVVEMLLKLFAMGSRTYFASKFNRFDCVVIVGSAAE 467
Query: 1654 FVL--VYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXX 1827
+ VY G+SV+R+ RLLRIFK+T YW
Sbjct: 468 VIWAEVYGG---SFGISVMRALRLLRIFKLTSYWVSLRNLVRSLMNSMRSIISLLFLLFL 524
Query: 1828 XXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQ---------------ILT 1962
GMQ+FGG+FNF P +FDTF AL+TVFQ ILT
Sbjct: 525 FILIFALLGMQLFGGRFNFPTMHPY--THFDTFPVALITVFQVSKNVINCKCINVLKILT 582
Query: 1963 GEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTN 2142
GEDWN VMY IES GG+ + G IY+IVL + GNY LLNVFLAIAVDNLA+A LT
Sbjct: 583 GEDWNEVMYLAIESQGGIYSGGWPYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTA 642
Query: 2143 AXXXXXXXXXXXXXXXXXX---------XXXXXXXXXXXXXXXXXXMTSARPRRMSEVPA 2295
A M E
Sbjct: 643 AEEADEKANEIEEESEELDEQYQEGDHCTIDMEGKTAGDMCAVARAMDDLDEECEEEESP 702
Query: 2296 ASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANS 2475
KP+ SS+F LS TN FRV + +V YF V+ I +SS LAAEDP+ +
Sbjct: 703 FGGPKPMVPYSSMFFLSPTNPFRVLIHSIVCTKYFEMMVMTVICLSSVSLAAEDPVDEEN 762
Query: 2476 TRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLR 2655
RN +L Y DY FT VF E+ LK+I G++ H GS+CR+ +N+LD +VV +L +F
Sbjct: 763 PRNKVLQYMDYCFTGVFACEMLLKLIDQGILLHPGSYCRDFWNILDGIVVTCALFAFGFA 822
Query: 2656 TDAMSXXXXXXXXXXXXXXXA------INRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQF 2817
S I R LK V CV+ ++K + NI++V F+ QF
Sbjct: 823 GTEGSAGKNLNTIKSLRVLRVLRPLKTIKRIPKLKAVFDCVVNSLKNVFNILIVYFLFQF 882
Query: 2818 MFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYED-GDPTKPVSKKRVWSNNDFNFDN 2994
+FA+I VQLF G FF C D ++ C G++ Y++ DP P ++R W FN+DN
Sbjct: 883 IFAVIAVQLFNGKFFFCTDKNRKFANTCHGQFFVYDNQNDP--PRVEQREWRLRPFNYDN 940
Query: 2995 VGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXX 3174
+AM++LFVV+T EGWP + ++D+ ED+GP R VAL
Sbjct: 941 TINAMLTLFVVTTGEGWPGIRQNSMDTTFEDQGPSPFFRVEVALFYVMFFIVFPFFFVNI 1000
Query: 3175 XXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIP--RNRLQYRVWWFVTS 3348
+I+TFQ +GE E +LDKNQ++CI+FAL A+P ++P +N +YR+W VTS
Sbjct: 1001 FVALIIITFQEQGEAELSEGDLDKNQKQCIDFALNARPRSLFMPEDKNSTKYRIWRLVTS 1060
Query: 3349 RAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNY 3528
FEY I +I NT+ L K+Y + +E+ L +FN T VF E++LKI+A +NY
Sbjct: 1061 PPFEYFIMTMICCNTLILMMKYYNNPLFYEEILRLFNTALTAVFTVESILKILAFGVRNY 1120
Query: 3529 ISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLL 3708
D WN FD + VVGS D + G + +S+ F RLFR RL++LL +G IR LL
Sbjct: 1121 FRDGWNRFDFVTVVGSITDALVTEF---GGHFVSLGFLRLFRAARLIRLLQQGYTIRILL 1177
Query: 3709 WTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLF 3888
WTF++SF+ALPYV LLI +LFFIYA++GMQ FG + L+ +T I+R+NNF SF A+++LF
Sbjct: 1178 WTFVQSFKALPYVCLLIGMLFFIYAIVGMQVFGNIWLNAATEINRHNNFQSFFNAVILLF 1237
Query: 3889 RSATGEAWQDIMLSCSDRED-VRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFL 4065
R ATGE WQDIM++ +D R ++ KG CG+N +Y YF SF L SFL
Sbjct: 1238 RCATGEGWQDIMMAAVQGKDCARAGSAEINFEKG----QTCGSNVSYAYFTSFVFLSSFL 1293
Query: 4066 VINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
++NLFVAVIMDNFDYLTRD SILGPHHL+EF+R+W++YDP A GRI + ++ +LR ++P
Sbjct: 1294 MLNLFVAVIMDNFDYLTRDSSILGPHHLDEFIRVWADYDPAATGRIHYSEMYEMLRIMAP 1353
Query: 4246 PLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNL--KIYTEGNIDEANEQ 4419
P+GFGK CP+RLA K L+ MNMP+ DGTV F TLFAL+R +L K+ +DEA+E+
Sbjct: 1354 PVGFGKKCPYRLAYKHLIRMNMPVAEDGTVHFTTTLFALIRESLSIKMRPVEEMDEADEE 1413
Query: 4420 LRSAIKRIWK-RTHKDLLDEVVPPAGK--EDDVTVGKFYATFLIQDYFRRFKKRKEMEAK 4590
LR +K+IW + K+++D VVPP + +TVGK YA LI + +R K E+ +
Sbjct: 1414 LRLTLKKIWPLKAKKNMVDLVVPPNHELCFQKLTVGKIYAGLLILENYRARKSGTEVGGQ 1473
Query: 4591 GVLPAQTPQAMALQAGLRTLHE------------IGPELKRAISGNLETDFNFDEPEPQ- 4731
G+ +A + H I P+ + S + Q
Sbjct: 1474 GLFGGGLRSLVAAAKAAESQHSSHTPQPPEETTPIIPQHAQQFSAAPTMSAQGSLQQMQG 1533
Query: 4732 -----HRRPHSLFNNLVHRLSGA---GSKSPTEHERIEKGSTLLPFQPRSFSPTHS--LA 4881
+RP+SLFN+ V + G + +++ +++ + R S S
Sbjct: 1534 TSSGGGQRPYSLFNSFVDTIKSGKQDGDVTDVQYQSVDQQHEKMNSTGRRLSDMFSKIRR 1593
Query: 4882 GAEGSPVPSQM-HRGAPINQSINLPPVNGSARRLPALPPYANHIHDETDDGPRYR---DT 5049
G P Q H A N+S + P AR P P + PRYR
Sbjct: 1594 GTSADHNPHQTEHLLAQDNRSPSSPRYRSMARASPPSPA------ERYGHPPRYRTESPP 1647
Query: 5050 GDRAGYDQSSRMVVANRN 5103
R+ Y S R + RN
Sbjct: 1648 SSRSEYQMSIRDPIIRRN 1665
Score = 113 bits (282), Expect = 6e-23
Identities = 90/336 (26%), Positives = 156/336 (45%), Gaps = 16/336 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP R L SIV K FE +++ +IC + ++LA P + + +N +L+ ++Y F VF
Sbjct: 722 NPFRVLIHSIVCTKYFEMMVMTVICLSSVSLAAEDP--VDEENPRNKVLQYMDYCFTGVF 779
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGF------DVKA 564
E +LK++ G + HP +Y R+ WNILD I+V L + +G +K+
Sbjct: 780 ACEMLLKLIDQGILLHPGSYCRDFWNILDGIVVTCALFA--FGFAGTEGSAGKNLNTIKS 837
Query: 565 LRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLH 744
LR RVLRPL+ + +P L+ V + ++ ++ + +I ++ I+A+I ++LF GK
Sbjct: 838 LRVLRVLRPLKTIKRIPKLKAVFDCVVNSLKNVFNILIVYFLFQFIFAVIAVQLFNGKFF 897
Query: 745 STCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVR-WECSSNTTWPGPNNGIT 921
C D +K C G F + + R W
Sbjct: 898 -FCTDK-----NRKFANTC----HGQFFVYDNQNDPPRVEQREWRLRP-----------F 936
Query: 922 NFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREW---PW------IYFVTLVILGSFF 1074
N+DN AMLT+F + EGW + D + P+ +++V I+ FF
Sbjct: 937 NYDNTINAMLTLFVVTTGEGWPGIRQNSMDTTFEDQGPSPFFRVEVALFYVMFFIVFPFF 996
Query: 1075 VLNLVLGVLSGEFSKEREKARARGLFQKFREKQQLE 1182
+N+ + ++ F ++ E + G K +KQ ++
Sbjct: 997 FVNIFVALIIITFQEQGEAELSEGDLDK-NQKQCID 1031
Score = 95.1 bits (235), Expect = 2e-17
Identities = 80/345 (23%), Positives = 155/345 (44%), Gaps = 24/345 (6%)
Frame = +1
Query: 229 IRKLCISI---VEWKPFEFLILFMICAN-CIALAIYQPYPAQDSDYKNTLLETIEYVFIV 396
I++L I I V+ + F + ++ ++ N C + + P +D+ L+ E+VF+
Sbjct: 375 IKQLRIQIRIMVKTQIFYWSVITLVFLNTCCVASEHYGQPQWFTDF----LKYAEFVFLG 430
Query: 397 VFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAF 576
+F +E +LK+ AMG Y + +N D +++V I +++ F + +RA
Sbjct: 431 IFVVEMLLKLFAMG----SRTYFASKFNRFDCVVIVGSAAEVIWAEVYGGSFGISVMRAL 486
Query: 577 RVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI 756
R+LR +L S SL+ ++ +++ +M ++ + L+ ILI+A++G++LF G+ + +
Sbjct: 487 RLLRIFKLTSYWVSLRNLVRSLMNSMRSIISLLFLLFLFILIFALLGMQLFGGRFNFPTM 546
Query: 757 DPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNF 936
P T +FD F
Sbjct: 547 HPYT---------------------------------------------------HFDTF 555
Query: 937 GLAMLTVFQ---------CVSL------EGWTDVMYWVNDAVG----REWPW-IYFVTLV 1056
+A++TVFQ C+++ E W +VMY ++ G WP+ IYF+ LV
Sbjct: 556 PVALITVFQVSKNVINCKCINVLKILTGEDWNEVMYLAIESQGGIYSGGWPYSIYFIVLV 615
Query: 1057 ILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDL 1191
+ G++ +LN+ L + + +E A +K E ++ E+L
Sbjct: 616 LFGNYTLLNVFLAIAVDNLANAQELTAAEEADEKANEIEEESEEL 660
Score = 86.7 bits (213), Expect = 6e-15
Identities = 73/307 (23%), Positives = 124/307 (39%), Gaps = 19/307 (6%)
Frame = +1
Query: 250 IVEWKPFEFLILFMICANCIALAI-YQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKI 426
+V PFE+ I+ MIC N + L + Y P + +L VFT+E +LKI
Sbjct: 1057 LVTSPPFEYFIMTMICCNTLILMMKYYNNPL----FYEEILRLFNTALTAVFTVESILKI 1112
Query: 427 VAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVS 606
+A G Y R+ WN DF+ VV + ++++ + LR FR R +RL+
Sbjct: 1113 LAFGVR----NYFRDGWNRFDFVTVVGSITDALVTEFGGHFVSLGFLRLFRAARLIRLLQ 1168
Query: 607 GVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQK 786
+++++L +++ L ++ LL+ + IYAI+G+++F
Sbjct: 1169 QGYTIRILLWTFVQSFKALPYVCLLIGMLFFIYAIVGMQVF------------------- 1209
Query: 787 DPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQC 966
G W + T +N +F N A++ +F+C
Sbjct: 1210 -------------------------GNIW--LNAATEINRHNNFQSFFN---AVILLFRC 1239
Query: 967 VSLEGWTDVM------------------YWVNDAVGREWPWIYFVTLVILGSFFVLNLVL 1092
+ EGW D+M + G + YF + V L SF +LNL +
Sbjct: 1240 ATGEGWQDIMMAAVQGKDCARAGSAEINFEKGQTCGSNVSYAYFTSFVFLSSFLMLNLFV 1299
Query: 1093 GVLSGEF 1113
V+ F
Sbjct: 1300 AVIMDNF 1306
>gi|25146680|ref|NP_741733.1| UNCoordinated locomotion UNC-2,
voltage-gated Calcium Channel Alpha subunit (unc-2)
[Caenorhabditis elegans]
gi|21629465|gb|AAM69092.1| Uncoordinated protein 2, isoform c
[Caenorhabditis elegans]
Length = 1926
Score = 1077 bits (2786), Expect = 0.0
Identities = 662/1716 (38%), Positives = 904/1716 (52%), Gaps = 123/1716 (7%)
Frame = +1
Query: 325 QPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVV 504
Q P D + LE E F+ +F +ECVLK++A GF H +YLR+ WNI+DFI+VV
Sbjct: 3 QHLPKNDKKALSEWLERTEPYFMGIFCLECVLKVIAFGFALHKGSYLRSGWNIMDFIVVV 62
Query: 505 IGLVS-------TILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPL 663
G+V+ T + + D++ LRA RVLRPL+LVSG+PSLQVVL +IL AM PL
Sbjct: 63 SGVVTMLPFSPATQTANQPVDSVDLRTLRAVRVLRPLKLVSGIPSLQVVLKSILCAMAPL 122
Query: 664 LHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQL--AQKDPTPCGTDTEGSAFKCQ 837
L I LLVLF I+I+AIIGLE + G HS C + G++ + P PC T
Sbjct: 123 LQIGLLVLFAIIIFAIIGLEFYSGAFHSACYNER-GEIENVSERPMPCTNKT-------- 173
Query: 838 PSDSLTNMGVRWECSSNTT-----WPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYW 1002
+ MGV + C T W GPN GIT+FDN G AM+TVFQC+++EGWT VMY+
Sbjct: 174 -----SPMGV-YNCDVKGTTCLQKWIGPNYGITSFDNIGFAMITVFQCITMEGWTTVMYY 227
Query: 1003 VNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQQLE 1182
ND++G + W YF+ L++LGSFF+LNLVLGVLSGEF+KERE+ R F K R +QQ+E
Sbjct: 228 TNDSLGSTYNWAYFIPLIVLGSFFMLNLVLGVLSGEFAKERERVENRREFLKLRRQQQIE 287
Query: 1183 EDLKGYLDWITQAEDIEPVNEDEQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKW------ 1344
+L GYL+WI AE++ + E+E A ++
Sbjct: 288 RELNGYLEWILTAEEVILKEDRTTEEEKAAIMEARRRAANKKLKQASKQQSTETEEDFEE 347
Query: 1345 ------------AARMKR-----LEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXT 1473
A R KR + K +VK+Q FYW
Sbjct: 348 DEDEMEEEYVDEAERKKRGCCHSVGKFIKQLRIQIRIMVKTQIFYWSVITLVFLNTCCVA 407
Query: 1474 SEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILE 1653
SEHYGQ +W F A F+ +F +EMLLK++++G TY S+FNRFDC V++ S E
Sbjct: 408 SEHYGQPQWFTDFLKYAEFVFLGIFVVEMLLKLFAMGSRTYFASKFNRFDCVVIVGSAAE 467
Query: 1654 FVL--VYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXX 1827
+ VY G+SV+R+ RLLRIFK+T YW
Sbjct: 468 VIWAEVYGG---SFGISVMRALRLLRIFKLTSYWVSLRNLVRSLMNSMRSIISLLFLLFL 524
Query: 1828 XXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQ---------------ILT 1962
GMQ+FGG+FNF P +FDTF AL+TVFQ ILT
Sbjct: 525 FILIFALLGMQLFGGRFNFPTMHPY--THFDTFPVALITVFQVSKNVINCKCINVLKILT 582
Query: 1963 GEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTN 2142
GEDWN VMY IES GG+ + G IY+IVL + GNY LLNVFLAIAVDNLA+A LT
Sbjct: 583 GEDWNEVMYLAIESQGGIYSGGWPYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTA 642
Query: 2143 AXXXXXXXXXXXXXXXXXX---------XXXXXXXXXXXXXXXXXXMTSARPRRMSEVPA 2295
A M E
Sbjct: 643 AEEADEKANEIEEESEELDEQYQEGDHCTIDMEGKTAGDMCAVARAMDDLDEECEEEESP 702
Query: 2296 ASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANS 2475
KP+ SS+F LS TN FRV + +V YF V+ I +SS LAAEDP+ +
Sbjct: 703 FGGPKPMVPYSSMFFLSPTNPFRVLIHSIVCTKYFEMMVMTVICLSSVSLAAEDPVDEEN 762
Query: 2476 TRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLR 2655
RN +L Y DY FT VF E+ LK+I G++ H GS+CR+ +N+LD +VV +L +F
Sbjct: 763 PRNKVLQYMDYCFTGVFACEMLLKLIDQGILLHPGSYCRDFWNILDGIVVTCALFAFGFA 822
Query: 2656 TDAMSXXXXXXXXXXXXXXXA------INRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQF 2817
S I R LK V CV+ ++K + NI++V F+ QF
Sbjct: 823 GTEGSAGKNLNTIKSLRVLRVLRPLKTIKRIPKLKAVFDCVVNSLKNVFNILIVYFLFQF 882
Query: 2818 MFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYED-GDPTKPVSKKRVWSNNDFNFDN 2994
+FA+I VQLF G FF C D ++ C G++ Y++ DP P ++R W FN+DN
Sbjct: 883 IFAVIAVQLFNGKFFFCTDKNRKFANTCHGQFFVYDNQNDP--PRVEQREWRLRPFNYDN 940
Query: 2995 VGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXX 3174
+AM++LFVV+T EGWP + ++D+ ED+GP R VAL
Sbjct: 941 TINAMLTLFVVTTGEGWPGIRQNSMDTTFEDQGPSPFFRVEVALFYVMFFIVFPFFFVNI 1000
Query: 3175 XXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIP--RNRLQYRVWWFVTS 3348
+I+TFQ +GE E +LDKNQ++CI+FAL A+P ++P +N +YR+W VTS
Sbjct: 1001 FVALIIITFQEQGEAELSEGDLDKNQKQCIDFALNARPRSLFMPEDKNSTKYRIWRLVTS 1060
Query: 3349 RAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNY 3528
FEY I +I NT+ L K+Y + +E+ L +FN T VF E++LKI+A +NY
Sbjct: 1061 PPFEYFIMTMICCNTLILMMKYYNNPLFYEEILRLFNTALTAVFTVESILKILAFGVRNY 1120
Query: 3529 ISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLL 3708
D WN FD + VVGS D + G + +S+ F RLFR RL++LL +G IR LL
Sbjct: 1121 FRDGWNRFDFVTVVGSITDALVTEF---GGHFVSLGFLRLFRAARLIRLLQQGYTIRILL 1177
Query: 3709 WTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLF 3888
WTF++SF+ALPYV LLI +LFFIYA++GMQ FG + L+ +T I+R+NNF SF A+++LF
Sbjct: 1178 WTFVQSFKALPYVCLLIGMLFFIYAIVGMQVFGNIWLNAATEINRHNNFQSFFNAVILLF 1237
Query: 3889 RSATGEAWQDIMLSCSDRED-VRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFL 4065
R ATGE WQDIM++ +D R ++ KG CG+N +Y YF SF L SFL
Sbjct: 1238 RCATGEGWQDIMMAAVQGKDCARAGSAEINFEKG----QTCGSNVSYAYFTSFVFLSSFL 1293
Query: 4066 VINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
++NLFVAVIMDNFDYLTRD SILGPHHL+EF+R+W++YDP A GRI + ++ +LR ++P
Sbjct: 1294 MLNLFVAVIMDNFDYLTRDSSILGPHHLDEFIRVWADYDPAATGRIHYSEMYEMLRIMAP 1353
Query: 4246 PLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNL--KIYTEGNIDEANEQ 4419
P+GFGK CP+RLA K L+ MNMP+ DGTV F TLFAL+R +L K+ +DEA+E+
Sbjct: 1354 PVGFGKKCPYRLAYKHLIRMNMPVAEDGTVHFTTTLFALIRESLSIKMRPVEEMDEADEE 1413
Query: 4420 LRSAIKRIWK-RTHKDLLDEVVPPAGK--EDDVTVGKFYATFLIQDYFRRFKKRKEMEAK 4590
LR +K+IW + K+++D VVPP + +TVGK YA LI + +R K E+ +
Sbjct: 1414 LRLTLKKIWPLKAKKNMVDLVVPPNHELCFQKLTVGKIYAGLLILENYRARKSGTEVGGQ 1473
Query: 4591 GVLPAQTPQAMALQAGLRTLHE------------IGPELKRAISGNLETDFNFDEPEPQ- 4731
G+ +A + H I P+ + S + Q
Sbjct: 1474 GLFGGGLRSLVAAAKAAESQHSSHTPQPPEETTPIIPQHAQQFSAAPTMSAQGSLQQMQG 1533
Query: 4732 -----HRRPHSLFNNLV------------------------HRLSGAGSKSPTEHERIEK 4824
+RP+SLFN+ V +++ G + +I +
Sbjct: 1534 TSSGGGQRPYSLFNSFVDTIKSGKQDGDVTDVQYQSVDQQHEKMNSTGRRLSDMFSKIRR 1593
Query: 4825 GSTLLPFQPRSFSPTHSLAGAEGSPVPSQMHRGAPINQSINLPPVNGSARRLPALPPYAN 5004
G++ +++S + GS H A N+S + P AR P P
Sbjct: 1594 GTSADHNPHQNYSHRFGYSRNRGSRYDETEHLLAQDNRSPSSPRYRSMARASPPSPA--- 1650
Query: 5005 HIHDETDDGPRYR---DTGDRAGYDQSSRMVVANRN 5103
+ PRYR R+ Y S R + RN
Sbjct: 1651 ---ERYGHPPRYRTESPPSSRSEYQMSIRDPIIRRN 1683
Score = 113 bits (282), Expect = 6e-23
Identities = 90/336 (26%), Positives = 156/336 (45%), Gaps = 16/336 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP R L SIV K FE +++ +IC + ++LA P + + +N +L+ ++Y F VF
Sbjct: 722 NPFRVLIHSIVCTKYFEMMVMTVICLSSVSLAAEDP--VDEENPRNKVLQYMDYCFTGVF 779
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGF------DVKA 564
E +LK++ G + HP +Y R+ WNILD I+V L + +G +K+
Sbjct: 780 ACEMLLKLIDQGILLHPGSYCRDFWNILDGIVVTCALFA--FGFAGTEGSAGKNLNTIKS 837
Query: 565 LRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLH 744
LR RVLRPL+ + +P L+ V + ++ ++ + +I ++ I+A+I ++LF GK
Sbjct: 838 LRVLRVLRPLKTIKRIPKLKAVFDCVVNSLKNVFNILIVYFLFQFIFAVIAVQLFNGKFF 897
Query: 745 STCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVR-WECSSNTTWPGPNNGIT 921
C D +K C G F + + R W
Sbjct: 898 -FCTDK-----NRKFANTC----HGQFFVYDNQNDPPRVEQREWRLRP-----------F 936
Query: 922 NFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREW---PW------IYFVTLVILGSFF 1074
N+DN AMLT+F + EGW + D + P+ +++V I+ FF
Sbjct: 937 NYDNTINAMLTLFVVTTGEGWPGIRQNSMDTTFEDQGPSPFFRVEVALFYVMFFIVFPFF 996
Query: 1075 VLNLVLGVLSGEFSKEREKARARGLFQKFREKQQLE 1182
+N+ + ++ F ++ E + G K +KQ ++
Sbjct: 997 FVNIFVALIIITFQEQGEAELSEGDLDK-NQKQCID 1031
Score = 95.1 bits (235), Expect = 2e-17
Identities = 80/345 (23%), Positives = 155/345 (44%), Gaps = 24/345 (6%)
Frame = +1
Query: 229 IRKLCISI---VEWKPFEFLILFMICAN-CIALAIYQPYPAQDSDYKNTLLETIEYVFIV 396
I++L I I V+ + F + ++ ++ N C + + P +D+ L+ E+VF+
Sbjct: 375 IKQLRIQIRIMVKTQIFYWSVITLVFLNTCCVASEHYGQPQWFTDF----LKYAEFVFLG 430
Query: 397 VFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAF 576
+F +E +LK+ AMG Y + +N D +++V I +++ F + +RA
Sbjct: 431 IFVVEMLLKLFAMG----SRTYFASKFNRFDCVVIVGSAAEVIWAEVYGGSFGISVMRAL 486
Query: 577 RVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI 756
R+LR +L S SL+ ++ +++ +M ++ + L+ ILI+A++G++LF G+ + +
Sbjct: 487 RLLRIFKLTSYWVSLRNLVRSLMNSMRSIISLLFLLFLFILIFALLGMQLFGGRFNFPTM 546
Query: 757 DPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNF 936
P T +FD F
Sbjct: 547 HPYT---------------------------------------------------HFDTF 555
Query: 937 GLAMLTVFQ---------CVSL------EGWTDVMYWVNDAVG----REWPW-IYFVTLV 1056
+A++TVFQ C+++ E W +VMY ++ G WP+ IYF+ LV
Sbjct: 556 PVALITVFQVSKNVINCKCINVLKILTGEDWNEVMYLAIESQGGIYSGGWPYSIYFIVLV 615
Query: 1057 ILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDL 1191
+ G++ +LN+ L + + +E A +K E ++ E+L
Sbjct: 616 LFGNYTLLNVFLAIAVDNLANAQELTAAEEADEKANEIEEESEEL 660
Score = 86.7 bits (213), Expect = 6e-15
Identities = 73/307 (23%), Positives = 124/307 (39%), Gaps = 19/307 (6%)
Frame = +1
Query: 250 IVEWKPFEFLILFMICANCIALAI-YQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKI 426
+V PFE+ I+ MIC N + L + Y P + +L VFT+E +LKI
Sbjct: 1057 LVTSPPFEYFIMTMICCNTLILMMKYYNNPL----FYEEILRLFNTALTAVFTVESILKI 1112
Query: 427 VAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVS 606
+A G Y R+ WN DF+ VV + ++++ + LR FR R +RL+
Sbjct: 1113 LAFGVR----NYFRDGWNRFDFVTVVGSITDALVTEFGGHFVSLGFLRLFRAARLIRLLQ 1168
Query: 607 GVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQK 786
+++++L +++ L ++ LL+ + IYAI+G+++F
Sbjct: 1169 QGYTIRILLWTFVQSFKALPYVCLLIGMLFFIYAIVGMQVF------------------- 1209
Query: 787 DPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQC 966
G W + T +N +F N A++ +F+C
Sbjct: 1210 -------------------------GNIW--LNAATEINRHNNFQSFFN---AVILLFRC 1239
Query: 967 VSLEGWTDVM------------------YWVNDAVGREWPWIYFVTLVILGSFFVLNLVL 1092
+ EGW D+M + G + YF + V L SF +LNL +
Sbjct: 1240 ATGEGWQDIMMAAVQGKDCARAGSAEINFEKGQTCGSNVSYAYFTSFVFLSSFLMLNLFV 1299
Query: 1093 GVLSGEF 1113
V+ F
Sbjct: 1300 AVIMDNF 1306
>gi|39591060|emb|CAE58840.1| Hypothetical protein CBG02059
[Caenorhabditis briggsae]
Length = 1536
Score = 1075 bits (2780), Expect = 0.0
Identities = 628/1505 (41%), Positives = 846/1505 (55%), Gaps = 79/1505 (5%)
Frame = +1
Query: 325 QPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVV 504
Q P D + LE E F+ +F +EC+LK++A GF FH +YLR+ WNI+DFI+VV
Sbjct: 3 QHLPKNDKKALSEWLERTEPYFMGIFCLECILKVIAFGFAFHKGSYLRSGWNIMDFIVVV 62
Query: 505 IGLVSTILSKMSIQG-------FDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPL 663
G+V+ + +IQ D++ LRA RVLRPL+LVSG+PSLQVVL +IL AM PL
Sbjct: 63 SGVVTMLPFGSTIQAANQPVDTVDLRTLRAVRVLRPLKLVSGIPSLQVVLKSILCAMAPL 122
Query: 664 LHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQL--AQKDPTPCGTDTEGSAFKCQ 837
L I LLVLF I+I+AIIGLE + G HS C + G++ + P PC T
Sbjct: 123 LQIGLLVLFAIIIFAIIGLEFYSGAFHSACYNER-GEIENVSEKPMPCTNKT-------- 173
Query: 838 PSDSLTNMGVRWECSSNTT-----WPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYW 1002
+ MGV + C T W GPN GIT+FDN G AM+TVFQC+++EGWT VMY+
Sbjct: 174 -----SPMGV-YNCDVKGTTCLQKWIGPNYGITSFDNIGFAMITVFQCITMEGWTTVMYY 227
Query: 1003 VNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQQLE 1182
ND++G + W YF+ L++LGSFF+LNLVLGVLSGEF+KERE+ R F K R +QQ+E
Sbjct: 228 TNDSLGSTYNWAYFIPLIVLGSFFMLNLVLGVLSGEFAKERERVENRREFLKLRRQQQIE 287
Query: 1183 EDLKGYLDWITQAEDIEPVNEDEQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKW------ 1344
+L GYL+WI AE++ + E+E A ++
Sbjct: 288 RELNGYLEWILTAEEVILKEDRTTEEEKAAIMEARRRAANKKLKQASKQQSTETEEDFEE 347
Query: 1345 ------------AARMKR-----LEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXT 1473
A R KR L K +VK+Q FYW
Sbjct: 348 DEDEMEEEYVDEAERKKRGCCHSLGKFIKQLRIQIRIMVKTQIFYWSVITLVFLNTCCVA 407
Query: 1474 SEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILE 1653
SEHYGQ +W F A F+ +F +EMLLK++++G TY S+FNRFDC V++ S E
Sbjct: 408 SEHYGQPQWFTDFLKYAEFVFLGIFVVEMLLKLFAMGSRTYFASKFNRFDCVVIVGSAAE 467
Query: 1654 FVL--VYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXX 1827
+ VY G+SV+R+ RLLRIFK+T YW
Sbjct: 468 VIWAEVYGG---SFGISVMRALRLLRIFKLTSYWVSLRNLVRSLMNSMRSIISLLFLLFL 524
Query: 1828 XXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQ----------------IL 1959
GMQ+FGG+FNF P +FDTF AL+TVFQ IL
Sbjct: 525 FILIFALLGMQLFGGRFNFPTMHPY--THFDTFPVALITVFQVSSINCHRNFELKFFKIL 582
Query: 1960 TGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLT 2139
TGEDWN VMY IES GG+ + G IY+IVL + GNY LLNVFLAIAVDNLA+A LT
Sbjct: 583 TGEDWNEVMYLAIESQGGIYSGGWPYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELT 642
Query: 2140 NAXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXMTSARPRRMSEVPAASTV--- 2307
A A R M E+
Sbjct: 643 AAEEADEKANEIEEESEEVDEQFQEGDHCTIDMEGKTAGDMCAVARAMDEMDEECEEEES 702
Query: 2308 -----KPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN 2472
KP+ SS+F LS TN FRV + +V YF V+ I +SS LAAEDP+
Sbjct: 703 PFGGPKPMVPYSSMFFLSPTNPFRVLIHSIVCTKYFEMMVMTVICLSSVSLAAEDPVDEE 762
Query: 2473 STRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL 2652
+ RN +L Y DY FT VF E+ LK+I G++ H GS+CR+ +N+LD +VV +L +F
Sbjct: 763 NPRNKVLQYMDYCFTGVFACEMLLKLIDQGILLHPGSYCRDFWNILDGIVVTCALFAFGF 822
Query: 2653 RTDAMSXXXXXXXXXXXXXXXA------INRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQ 2814
S I R LK V CV+ ++K + NI++V F+ Q
Sbjct: 823 AGTEGSAGKNLNTIKSLRVLRVLRPLKTIKRIPKLKAVFDCVVNSLKNVFNILIVYFLFQ 882
Query: 2815 FMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYED-GDPTKPVSKKRVWSNNDFNFD 2991
F+FA+I VQLF G FF C D ++ C G++ Y++ DP P ++R W FN+D
Sbjct: 883 FIFAVIAVQLFNGKFFFCTDKNRKFAHTCHGQFFVYDNQNDP--PRVEQREWRLRPFNYD 940
Query: 2992 NVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXX 3171
N +AM++LFVV+T EGWP + ++D+ ED+GP R VAL
Sbjct: 941 NTINAMLTLFVVTTGEGWPGIRQNSMDTTFEDQGPSPFFRVEVALFYVMFFIVFPFFFVN 1000
Query: 3172 XXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIP--RNRLQYRVWWFVT 3345
+I+TFQ +GE E +LDKNQ++CI+FAL A+P ++P +N +YR+W VT
Sbjct: 1001 IFVALIIITFQEQGEAELSEGDLDKNQKQCIDFALNARPRSLFMPEDKNSTKYRIWRLVT 1060
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY I +I NT+ L K+Y + +E+ L +FN T VF E++LKI+A +N
Sbjct: 1061 SPPFEYFIMTMICCNTLILMMKYYNNPLFYEEILRLFNTALTAVFTVESILKILAFGVRN 1120
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTL 3705
Y D WN FD + VVGS D + G + +S+ F RLFR RL++LL +G IR L
Sbjct: 1121 YFRDGWNRFDFVTVVGSITDALVTEF---GGHFVSLGFLRLFRAARLIRLLQQGYTIRIL 1177
Query: 3706 LWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVL 3885
LWTF++SF+ALPYV LLI +LFFIYA++GMQ FG + L+ +T I+R+NNF SF A+++L
Sbjct: 1178 LWTFVQSFKALPYVCLLIGMLFFIYAIVGMQVFGNIWLNAATEINRHNNFQSFFNAVILL 1237
Query: 3886 FRSATGEAWQDIMLSCSDRED-VRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSF 4062
FR ATGE WQDIM++ +D R ++ KG CG+N +Y YF SF L SF
Sbjct: 1238 FRCATGEGWQDIMMAAVQGKDCARAGSAEINFEKG----QTCGSNVSYAYFTSFVFLSSF 1293
Query: 4063 LVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKIS 4242
L++NLFVAVIMDNFDYLTRD SILGPHHL+EF+R+W++YDP A GRI + ++ +LR ++
Sbjct: 1294 LMLNLFVAVIMDNFDYLTRDSSILGPHHLDEFIRVWADYDPAATGRIHYTEMYEMLRIMA 1353
Query: 4243 PPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNL--KIYTEGNIDEANE 4416
PP+GFGK CP+RLA K L+ MNMP+ DGTV F TLFAL+R +L K+ +DEA+E
Sbjct: 1354 PPVGFGKKCPYRLAYKHLIRMNMPVAEDGTVHFTTTLFALIRESLSIKMRPVEEMDEADE 1413
Query: 4417 QLRSAIKRIWK-RTHKDLLDEVVPPAGK--EDDVTVGKFYATFLIQDYFRRFKKRKEMEA 4587
+LR +K+IW + K+++D VVPP + +TVGK YA LI + +R K E ++
Sbjct: 1414 ELRLTLKKIWPLKAKKNMVDLVVPPNHELCFQKLTVGKIYAGLLILENYRARKSGTERQS 1473
Query: 4588 KGVLP 4602
+P
Sbjct: 1474 NDSVP 1478
Score = 112 bits (280), Expect = 1e-22
Identities = 89/342 (26%), Positives = 155/342 (45%), Gaps = 22/342 (6%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP R L SIV K FE +++ +IC + ++LA P + + +N +L+ ++Y F VF
Sbjct: 723 NPFRVLIHSIVCTKYFEMMVMTVICLSSVSLAAEDP--VDEENPRNKVLQYMDYCFTGVF 780
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGF------DVKA 564
E +LK++ G + HP +Y R+ WNILD I+V L + +G +K+
Sbjct: 781 ACEMLLKLIDQGILLHPGSYCRDFWNILDGIVVTCALFA--FGFAGTEGSAGKNLNTIKS 838
Query: 565 LRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLH 744
LR RVLRPL+ + +P L+ V + ++ ++ + +I ++ I+A+I ++LF GK
Sbjct: 839 LRVLRVLRPLKTIKRIPKLKAVFDCVVNSLKNVFNILIVYFLFQFIFAVIAVQLFNGKFF 898
Query: 745 STCID-------PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPG 903
C D GQ D E ++ +P
Sbjct: 899 -FCTDKNRKFAHTCHGQFFVYDNQNDPPRVEQREWRLRP--------------------- 936
Query: 904 PNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREW---PW------IYFVTLV 1056
N+DN AMLT+F + EGW + D + P+ +++V
Sbjct: 937 -----FNYDNTINAMLTLFVVTTGEGWPGIRQNSMDTTFEDQGPSPFFRVEVALFYVMFF 991
Query: 1057 ILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQQLE 1182
I+ FF +N+ + ++ F ++ E + G K +KQ ++
Sbjct: 992 IVFPFFFVNIFVALIIITFQEQGEAELSEGDLDK-NQKQCID 1032
Score = 93.6 bits (231), Expect = 5e-17
Identities = 79/346 (22%), Positives = 153/346 (43%), Gaps = 25/346 (7%)
Frame = +1
Query: 229 IRKLCISI---VEWKPFEFLILFMICAN-CIALAIYQPYPAQDSDYKNTLLETIEYVFIV 396
I++L I I V+ + F + ++ ++ N C + + P +D+ L+ E+VF+
Sbjct: 375 IKQLRIQIRIMVKTQIFYWSVITLVFLNTCCVASEHYGQPQWFTDF----LKYAEFVFLG 430
Query: 397 VFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAF 576
+F +E +LK+ AMG Y + +N D +++V I +++ F + +RA
Sbjct: 431 IFVVEMLLKLFAMG----SRTYFASKFNRFDCVVIVGSAAEVIWAEVYGGSFGISVMRAL 486
Query: 577 RVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI 756
R+LR +L S SL+ ++ +++ +M ++ + L+ ILI+A++G++LF G+ + +
Sbjct: 487 RLLRIFKLTSYWVSLRNLVRSLMNSMRSIISLLFLLFLFILIFALLGMQLFGGRFNFPTM 546
Query: 757 DPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNF 936
P T +FD F
Sbjct: 547 HPYT---------------------------------------------------HFDTF 555
Query: 937 GLAMLTVFQCVSL----------------EGWTDVMYWVNDAVG----REWPW-IYFVTL 1053
+A++TVFQ S+ E W +VMY ++ G WP+ IYF+ L
Sbjct: 556 PVALITVFQVSSINCHRNFELKFFKILTGEDWNEVMYLAIESQGGIYSGGWPYSIYFIVL 615
Query: 1054 VILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDL 1191
V+ G++ +LN+ L + + +E A +K E ++ E++
Sbjct: 616 VLFGNYTLLNVFLAIAVDNLANAQELTAAEEADEKANEIEEESEEV 661
Score = 86.7 bits (213), Expect = 6e-15
Identities = 73/307 (23%), Positives = 124/307 (39%), Gaps = 19/307 (6%)
Frame = +1
Query: 250 IVEWKPFEFLILFMICANCIALAI-YQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKI 426
+V PFE+ I+ MIC N + L + Y P + +L VFT+E +LKI
Sbjct: 1058 LVTSPPFEYFIMTMICCNTLILMMKYYNNPL----FYEEILRLFNTALTAVFTVESILKI 1113
Query: 427 VAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVS 606
+A G Y R+ WN DF+ VV + ++++ + LR FR R +RL+
Sbjct: 1114 LAFGVR----NYFRDGWNRFDFVTVVGSITDALVTEFGGHFVSLGFLRLFRAARLIRLLQ 1169
Query: 607 GVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQK 786
+++++L +++ L ++ LL+ + IYAI+G+++F
Sbjct: 1170 QGYTIRILLWTFVQSFKALPYVCLLIGMLFFIYAIVGMQVF------------------- 1210
Query: 787 DPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQC 966
G W + T +N +F N A++ +F+C
Sbjct: 1211 -------------------------GNIW--LNAATEINRHNNFQSFFN---AVILLFRC 1240
Query: 967 VSLEGWTDVM------------------YWVNDAVGREWPWIYFVTLVILGSFFVLNLVL 1092
+ EGW D+M + G + YF + V L SF +LNL +
Sbjct: 1241 ATGEGWQDIMMAAVQGKDCARAGSAEINFEKGQTCGSNVSYAYFTSFVFLSSFLMLNLFV 1300
Query: 1093 GVLSGEF 1113
V+ F
Sbjct: 1301 AVIMDNF 1307
>gi|25146674|ref|NP_741734.1| UNCoordinated locomotion UNC-2,
voltage-gated Calcium Channel Alpha subunit (unc-2)
[Caenorhabditis elegans]
gi|17976551|gb|AAB36868.3| Uncoordinated protein 2, isoform a
[Caenorhabditis elegans]
Length = 1538
Score = 1072 bits (2772), Expect = 0.0
Identities = 624/1504 (41%), Positives = 841/1504 (55%), Gaps = 78/1504 (5%)
Frame = +1
Query: 325 QPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVV 504
Q P D + LE E F+ +F +ECVLK++A GF H +YLR+ WNI+DFI+VV
Sbjct: 3 QHLPKNDKKALSEWLERTEPYFMGIFCLECVLKVIAFGFALHKGSYLRSGWNIMDFIVVV 62
Query: 505 IGLVS-------TILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPL 663
G+V+ T + + D++ LRA RVLRPL+LVSG+PSLQVVL +IL AM PL
Sbjct: 63 SGVVTMLPFSPATQTANQPVDSVDLRTLRAVRVLRPLKLVSGIPSLQVVLKSILCAMAPL 122
Query: 664 LHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQL--AQKDPTPCGTDTEGSAFKCQ 837
L I LLVLF I+I+AIIGLE + G HS C + G++ + P PC T
Sbjct: 123 LQIGLLVLFAIIIFAIIGLEFYSGAFHSACYNER-GEIENVSERPMPCTNKT-------- 173
Query: 838 PSDSLTNMGVRWECSSNTT-----WPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYW 1002
+ MGV + C T W GPN GIT+FDN G AM+TVFQC+++EGWT VMY+
Sbjct: 174 -----SPMGV-YNCDVKGTTCLQKWIGPNYGITSFDNIGFAMITVFQCITMEGWTTVMYY 227
Query: 1003 VNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQQLE 1182
ND++G + W YF+ L++LGSFF+LNLVLGVLSGEF+KERE+ R F K R +QQ+E
Sbjct: 228 TNDSLGSTYNWAYFIPLIVLGSFFMLNLVLGVLSGEFAKERERVENRREFLKLRRQQQIE 287
Query: 1183 EDLKGYLDWITQAEDIEPVNEDEQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKW------ 1344
+L GYL+WI AE++ + E+E A ++
Sbjct: 288 RELNGYLEWILTAEEVILKEDRTTEEEKAAIMEARRRAANKKLKQASKQQSTETEEDFEE 347
Query: 1345 ------------AARMKR-----LEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXT 1473
A R KR + K +VK+Q FYW
Sbjct: 348 DEDEMEEEYVDEAERKKRGCCHSVGKFIKQLRIQIRIMVKTQIFYWSVITLVFLNTCCVA 407
Query: 1474 SEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILE 1653
SEHYGQ +W F A F+ +F +EMLLK++++G TY S+FNRFDC V++ S E
Sbjct: 408 SEHYGQPQWFTDFLKYAEFVFLGIFVVEMLLKLFAMGSRTYFASKFNRFDCVVIVGSAAE 467
Query: 1654 FVL--VYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXX 1827
+ VY G+SV+R+ RLLRIFK+T YW
Sbjct: 468 VIWAEVYGG---SFGISVMRALRLLRIFKLTSYWVSLRNLVRSLMNSMRSIISLLFLLFL 524
Query: 1828 XXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQ---------------ILT 1962
GMQ+FGG+FNF P +FDTF AL+TVFQ ILT
Sbjct: 525 FILIFALLGMQLFGGRFNFPTMHPY--THFDTFPVALITVFQVSKNVINCKCINVLKILT 582
Query: 1963 GEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTN 2142
GEDWN VMY IES GG+ + G IY+IVL + GNY LLNVFLAIAVDNLA+A LT
Sbjct: 583 GEDWNEVMYLAIESQGGIYSGGWPYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTA 642
Query: 2143 AXXXXXXXXXXXXXXXXXX---------XXXXXXXXXXXXXXXXXXMTSARPRRMSEVPA 2295
A M E
Sbjct: 643 AEEADEKANEIEEESEELDEQYQEGDHCTIDMEGKTAGDMCAVARAMDDLDEECEEEESP 702
Query: 2296 ASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANS 2475
KP+ SS+F LS TN FRV + +V YF V+ I +SS LAAEDP+ +
Sbjct: 703 FGGPKPMVPYSSMFFLSPTNPFRVLIHSIVCTKYFEMMVMTVICLSSVSLAAEDPVDEEN 762
Query: 2476 TRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLR 2655
RN +L Y DY FT VF E+ LK+I G++ H GS+CR+ +N+LD +VV +L +F
Sbjct: 763 PRNKVLQYMDYCFTGVFACEMLLKLIDQGILLHPGSYCRDFWNILDGIVVTCALFAFGFA 822
Query: 2656 TDAMSXXXXXXXXXXXXXXXA------INRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQF 2817
S I R LK V CV+ ++K + NI++V F+ QF
Sbjct: 823 GTEGSAGKNLNTIKSLRVLRVLRPLKTIKRIPKLKAVFDCVVNSLKNVFNILIVYFLFQF 882
Query: 2818 MFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYED-GDPTKPVSKKRVWSNNDFNFDN 2994
+FA+I VQLF G FF C D ++ C G++ Y++ DP P ++R W FN+DN
Sbjct: 883 IFAVIAVQLFNGKFFFCTDKNRKFANTCHGQFFVYDNQNDP--PRVEQREWRLRPFNYDN 940
Query: 2995 VGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXX 3174
+AM++LFVV+T EGWP + ++D+ ED+GP R VAL
Sbjct: 941 TINAMLTLFVVTTGEGWPGIRQNSMDTTFEDQGPSPFFRVEVALFYVMFFIVFPFFFVNI 1000
Query: 3175 XXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIP--RNRLQYRVWWFVTS 3348
+I+TFQ +GE E +LDKNQ++CI+FAL A+P ++P +N +YR+W VTS
Sbjct: 1001 FVALIIITFQEQGEAELSEGDLDKNQKQCIDFALNARPRSLFMPEDKNSTKYRIWRLVTS 1060
Query: 3349 RAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNY 3528
FEY I +I NT+ L K+Y + +E+ L +FN T VF E++LKI+A +NY
Sbjct: 1061 PPFEYFIMTMICCNTLILMMKYYNNPLFYEEILRLFNTALTAVFTVESILKILAFGVRNY 1120
Query: 3529 ISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLL 3708
D WN FD + VVGS D + G + +S+ F RLFR RL++LL +G IR LL
Sbjct: 1121 FRDGWNRFDFVTVVGSITDALVTEF---GGHFVSLGFLRLFRAARLIRLLQQGYTIRILL 1177
Query: 3709 WTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLF 3888
WTF++SF+ALPYV LLI +LFFIYA++GMQ FG + L+ +T I+R+NNF SF A+++LF
Sbjct: 1178 WTFVQSFKALPYVCLLIGMLFFIYAIVGMQVFGNIWLNAATEINRHNNFQSFFNAVILLF 1237
Query: 3889 RSATGEAWQDIMLSCSDRED-VRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFL 4065
R ATGE WQDIM++ +D R ++ KG CG+N +Y YF SF L SFL
Sbjct: 1238 RCATGEGWQDIMMAAVQGKDCARAGSAEINFEKG----QTCGSNVSYAYFTSFVFLSSFL 1293
Query: 4066 VINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
++NLFVAVIMDNFDYLTRD SILGPHHL+EF+R+W++YDP A GRI + ++ +LR ++P
Sbjct: 1294 MLNLFVAVIMDNFDYLTRDSSILGPHHLDEFIRVWADYDPAATGRIHYSEMYEMLRIMAP 1353
Query: 4246 PLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNL--KIYTEGNIDEANEQ 4419
P+GFGK CP+RLA K L+ MNMP+ DGTV F TLFAL+R +L K+ +DEA+E+
Sbjct: 1354 PVGFGKKCPYRLAYKHLIRMNMPVAEDGTVHFTTTLFALIRESLSIKMRPVEEMDEADEE 1413
Query: 4420 LRSAIKRIWK-RTHKDLLDEVVPPAGK--EDDVTVGKFYATFLIQDYFRRFKKRKEMEAK 4590
LR +K+IW + K+++D VVPP + +TVGK YA LI + +R K E ++
Sbjct: 1414 LRLTLKKIWPLKAKKNMVDLVVPPNHELCFQKLTVGKIYAGLLILENYRARKSGTERQSN 1473
Query: 4591 GVLP 4602
+P
Sbjct: 1474 DSVP 1477
Score = 113 bits (282), Expect = 6e-23
Identities = 90/336 (26%), Positives = 156/336 (45%), Gaps = 16/336 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP R L SIV K FE +++ +IC + ++LA P + + +N +L+ ++Y F VF
Sbjct: 722 NPFRVLIHSIVCTKYFEMMVMTVICLSSVSLAAEDP--VDEENPRNKVLQYMDYCFTGVF 779
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGF------DVKA 564
E +LK++ G + HP +Y R+ WNILD I+V L + +G +K+
Sbjct: 780 ACEMLLKLIDQGILLHPGSYCRDFWNILDGIVVTCALFA--FGFAGTEGSAGKNLNTIKS 837
Query: 565 LRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLH 744
LR RVLRPL+ + +P L+ V + ++ ++ + +I ++ I+A+I ++LF GK
Sbjct: 838 LRVLRVLRPLKTIKRIPKLKAVFDCVVNSLKNVFNILIVYFLFQFIFAVIAVQLFNGKFF 897
Query: 745 STCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVR-WECSSNTTWPGPNNGIT 921
C D +K C G F + + R W
Sbjct: 898 -FCTDK-----NRKFANTC----HGQFFVYDNQNDPPRVEQREWRLRP-----------F 936
Query: 922 NFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREW---PW------IYFVTLVILGSFF 1074
N+DN AMLT+F + EGW + D + P+ +++V I+ FF
Sbjct: 937 NYDNTINAMLTLFVVTTGEGWPGIRQNSMDTTFEDQGPSPFFRVEVALFYVMFFIVFPFF 996
Query: 1075 VLNLVLGVLSGEFSKEREKARARGLFQKFREKQQLE 1182
+N+ + ++ F ++ E + G K +KQ ++
Sbjct: 997 FVNIFVALIIITFQEQGEAELSEGDLDK-NQKQCID 1031
Score = 95.1 bits (235), Expect = 2e-17
Identities = 80/345 (23%), Positives = 155/345 (44%), Gaps = 24/345 (6%)
Frame = +1
Query: 229 IRKLCISI---VEWKPFEFLILFMICAN-CIALAIYQPYPAQDSDYKNTLLETIEYVFIV 396
I++L I I V+ + F + ++ ++ N C + + P +D+ L+ E+VF+
Sbjct: 375 IKQLRIQIRIMVKTQIFYWSVITLVFLNTCCVASEHYGQPQWFTDF----LKYAEFVFLG 430
Query: 397 VFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAF 576
+F +E +LK+ AMG Y + +N D +++V I +++ F + +RA
Sbjct: 431 IFVVEMLLKLFAMG----SRTYFASKFNRFDCVVIVGSAAEVIWAEVYGGSFGISVMRAL 486
Query: 577 RVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI 756
R+LR +L S SL+ ++ +++ +M ++ + L+ ILI+A++G++LF G+ + +
Sbjct: 487 RLLRIFKLTSYWVSLRNLVRSLMNSMRSIISLLFLLFLFILIFALLGMQLFGGRFNFPTM 546
Query: 757 DPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNF 936
P T +FD F
Sbjct: 547 HPYT---------------------------------------------------HFDTF 555
Query: 937 GLAMLTVFQ---------CVSL------EGWTDVMYWVNDAVG----REWPW-IYFVTLV 1056
+A++TVFQ C+++ E W +VMY ++ G WP+ IYF+ LV
Sbjct: 556 PVALITVFQVSKNVINCKCINVLKILTGEDWNEVMYLAIESQGGIYSGGWPYSIYFIVLV 615
Query: 1057 ILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDL 1191
+ G++ +LN+ L + + +E A +K E ++ E+L
Sbjct: 616 LFGNYTLLNVFLAIAVDNLANAQELTAAEEADEKANEIEEESEEL 660
Score = 86.7 bits (213), Expect = 6e-15
Identities = 73/307 (23%), Positives = 124/307 (39%), Gaps = 19/307 (6%)
Frame = +1
Query: 250 IVEWKPFEFLILFMICANCIALAI-YQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKI 426
+V PFE+ I+ MIC N + L + Y P + +L VFT+E +LKI
Sbjct: 1057 LVTSPPFEYFIMTMICCNTLILMMKYYNNPL----FYEEILRLFNTALTAVFTVESILKI 1112
Query: 427 VAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVS 606
+A G Y R+ WN DF+ VV + ++++ + LR FR R +RL+
Sbjct: 1113 LAFGVR----NYFRDGWNRFDFVTVVGSITDALVTEFGGHFVSLGFLRLFRAARLIRLLQ 1168
Query: 607 GVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQK 786
+++++L +++ L ++ LL+ + IYAI+G+++F
Sbjct: 1169 QGYTIRILLWTFVQSFKALPYVCLLIGMLFFIYAIVGMQVF------------------- 1209
Query: 787 DPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQC 966
G W + T +N +F N A++ +F+C
Sbjct: 1210 -------------------------GNIW--LNAATEINRHNNFQSFFN---AVILLFRC 1239
Query: 967 VSLEGWTDVM------------------YWVNDAVGREWPWIYFVTLVILGSFFVLNLVL 1092
+ EGW D+M + G + YF + V L SF +LNL +
Sbjct: 1240 ATGEGWQDIMMAAVQGKDCARAGSAEINFEKGQTCGSNVSYAYFTSFVFLSSFLMLNLFV 1299
Query: 1093 GVLSGEF 1113
V+ F
Sbjct: 1300 AVIMDNF 1306
>gi|27413155|ref|NP_083257.1| calcium channel, voltage-dependent, L
type, alpha 1D subunit; alpha 1 E; mouse alpha 1 E;
Cav1.3alpha1 [Mus musculus]
gi|20339001|emb|CAD26884.1| L-type voltage-gated calcium channel
Cav1.3(1b) subunit [Mus musculus]
Length = 2166
Score = 1056 bits (2731), Expect = 0.0
Identities = 544/933 (58%), Positives = 679/933 (72%), Gaps = 11/933 (1%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPRR SE+ + PIP+ S+ FILS TN RV C+ ++NH FTN +L I++SSA L
Sbjct: 866 RPRRTSELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAAL 925
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP++++S RN IL YFDY FT++FTVEI LK+ FG HKG+FCRN FNLLD+LVV
Sbjct: 926 AAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVV 985
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
VSL SF +++ A+S AINRAKGLKHVVQCV VA++TIGNIM+VT
Sbjct: 986 GVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTT 1045
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG F+ C D +K ECRG +I Y+DGD PV ++R+W N+DFN
Sbjct: 1046 LLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFN 1105
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP LLY AIDSN E+ GP++N R +++
Sbjct: 1106 FDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENVGPVYNYRVEISIFFIIYIIIVAFFM 1165
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N QY+ W+ V
Sbjct: 1166 MNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVN 1225
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S+ F D +D+ N++FTGVF E VLK++A PK
Sbjct: 1226 SSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKG 1285
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKL-NPGGTNLISINFFRLFRVMRLVKLLSRGEGIRT 3702
Y SD WN FD L+V+GS ID+ + N +N ISI FFRLFRVMRLVKLLSRGEGIRT
Sbjct: 1286 YFSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFFRLFRVMRLVKLLSRGEGIRT 1345
Query: 3703 LLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILV 3882
LLWTF+KSFQALPYVALLI +LFFIYAVIGMQ FGKVA+ D+ I+RNNNF +FP A+L+
Sbjct: 1346 LLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLL 1405
Query: 3883 LFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSF 4062
LFR ATGEAWQ+IML+C + CDP SD Y+ G E CG+NFA YFISF+MLC+F
Sbjct: 1406 LFRCATGEAWQEIMLACLPGK--LCDPDSD-YNPG--EEYTCGSNFAIVYFISFYMLCAF 1460
Query: 4063 LVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKIS 4242
L+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+WSEYDP+AKGRIKHLDVVTLLR+I
Sbjct: 1461 LIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQ 1520
Query: 4243 PPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNIDEANEQL 4422
PPLGFGKLCPHR+ACKRLV+MNMPLNSDGTV FNATLFALVRT LKI TEGN+++ANE+L
Sbjct: 1521 PPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEEL 1580
Query: 4423 RSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEMEAKGVLP 4602
R+ IK+IWK+T LLD+VVPPAG +D+VTVGKFYATFLIQDYFR+FKKRKE G P
Sbjct: 1581 RAVIKKIWKKTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYP 1639
Query: 4603 AQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFD---EPEPQHRRPHSLFNNLVHR 4773
A+ +ALQAGLRTLH+IGPE++RAIS +L+ D D E E +R +L N V+
Sbjct: 1640 AKN-TTIALQAGLRTLHDIGPEIRRAISCDLQDDEPEDSKPEEEDVFKRNGALLGNHVNH 1698
Query: 4774 LSG----AGSKSPTEHERIEKGSTLLPFQPRSFSPTHSLAGAEG---SPVPSQMHRGAPI 4932
++ + ++ T H + +P + P AG G + + + AP
Sbjct: 1699 VNSDRRDSLQQTNTTHRPLHVQRPSMPPASDTEKPLFPPAGNSGCHNHHNHNSIGKQAPT 1758
Query: 4933 NQSINLPPVNGSARRLPALPPYANHIHDETDDG 5031
+ + NL N S + PP ++ +++G
Sbjct: 1759 STNANLNNANMS-KAAHGKPPSIGNLEHVSENG 1790
Score = 722 bits (1864), Expect = 0.0
Identities = 376/669 (56%), Positives = 449/669 (66%), Gaps = 27/669 (4%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
NNPIR+ CISIVEWKPF+ IL I ANC+ALAIY P+P DS+ N LE +EY F+++
Sbjct: 134 NNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLII 193
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQ----------- 546
FT+E LKI+A G + HP+AY+RN WN+LDF+IV++GL S IL +++ +
Sbjct: 194 FTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKS 253
Query: 547 -GFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLE 723
GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+I++AM+PLLHIALLVLFVI+IYAIIGLE
Sbjct: 254 GGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLE 313
Query: 724 LFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPG 903
LF GK+H TC + +A++DP PC G+ +C + + EC S W G
Sbjct: 314 LFIGKMHKTCFFADSDIVAEEDPAPCAFS--GNGRQCTANGT--------ECRSG--WVG 361
Query: 904 PNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLN 1083
PN GITNFDNF AMLTVFQC+++EGWTDV+YWVNDA+G EWPW+YFV+L+ILGSFFVLN
Sbjct: 362 PNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLN 421
Query: 1084 LVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDE 1263
LVLGVLSGEFSKEREKA+ARG FQK REKQQLEEDLKGYLDWITQ EDI+P NE+E +E
Sbjct: 422 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQVEDIDPENEEEGGEE 481
Query: 1264 -------PVAQTXXXXXXXXXXXXXX--------XXXXPSKWAARMKRLEKLNXXXXXXX 1398
P ++T SK + R +R + N
Sbjct: 482 GKRNTSMPTSETESVNTENVSGEGETQGCCGTLCQAISKSKLSRRWRRWNRFNRRRCRAA 541
Query: 1399 XXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYS 1578
VKS TFYW +SEHY Q +WL Q +AN + LF+ EML+KMYS
Sbjct: 542 ---VKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYS 598
Query: 1579 LGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXX 1758
LG Y S FNRFDCFVV I E +LV +LM PLGVSV R RLLRIFKVT++WT
Sbjct: 599 LGLQAYFVSLFNRFDCFVVCGGITETILVELELMSPLGVSVFRCVRLLRIFKVTRHWTSL 658
Query: 1759 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQAL 1938
GMQ+FGGKFNF+ Q K R+ FD F QAL
Sbjct: 659 SNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTK-RSTFDNFPQAL 717
Query: 1939 LTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNL 2118
LTVFQILTGEDWN VMY GI ++GG + G+IVCIY+I+LFICGNYILLNVFLAIAVDNL
Sbjct: 718 LTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNL 777
Query: 2119 ADADSLTNA 2145
ADA+SL A
Sbjct: 778 ADAESLNTA 786
Score = 128 bits (322), Expect = 1e-27
Identities = 92/312 (29%), Positives = 152/312 (48%), Gaps = 9/312 (2%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR C ++ F LIL I + ALA P + ++NT+L +Y F +F
Sbjct: 895 NPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPI--RSHSFRNTILGYFDYAFTAIF 952
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
T+E +LK+ G H A+ RN +N+LD ++V + LVS + +I VK LR RV
Sbjct: 953 TVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAIS--VVKILRVLRV 1010
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLR ++ L+ V+ + A+ + +I ++ + ++A IG++LF GK + C D
Sbjct: 1011 LRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFY-RCTDE 1069
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
A+ +P C F + + VR N+ + NFDN
Sbjct: 1070 -----AKSNPEEC-----RGLFILYKDGDVDSPVVRERIWQNSDF--------NFDNVLS 1111
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDAVG---------REWPWIYFVTLVILGSFFVLNLVLG 1095
AM+ +F + EGW ++Y D+ G R I+F+ +I+ +FF++N+ +G
Sbjct: 1112 AMMALFTVSTFEGWPALLYKAIDSNGENVGPVYNYRVEISIFFIIYIIIVAFFMMNIFVG 1171
Query: 1096 VLSGEFSKEREK 1131
+ F ++ EK
Sbjct: 1172 FVIVTFQEQGEK 1183
Score = 102 bits (255), Expect = 8e-20
Identities = 70/276 (25%), Positives = 134/276 (48%), Gaps = 1/276 (0%)
Frame = +1
Query: 3277 KAKPHRRYIPRNRL-QYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDV 3453
K+K RR+ NR + R V S F +++ +++ +NT++++ +HY D+
Sbjct: 520 KSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDI 579
Query: 3454 FNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISI 3633
N + +F E ++K+ +L + Y +N FD VV G + +L + + +
Sbjct: 580 ANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEL--MSPLGV 637
Query: 3634 NFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKV 3813
+ FR R++R+ K+ + L+ + + S +++ + LL+ L I++++GMQ FG
Sbjct: 638 SVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGK 697
Query: 3814 ALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGL 3993
D T R+ F +FP A+L +F+ TGE W +M GG
Sbjct: 698 FNFDETQTKRST-FDNFPQALLTVFQILTGEDWNAVMYD-------------GIMAYGGP 743
Query: 3994 NESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDN 4101
+ S YFI F+ +++++N+F+A+ +DN
Sbjct: 744 SSS---GMIVCIYFIILFICGNYILLNVFLAIAVDN 776
Score = 99.0 bits (245), Expect = 1e-18
Identities = 76/317 (23%), Positives = 135/317 (41%), Gaps = 20/317 (6%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP + +V PFE+++ +I N + LA+ Q Y + S N ++ + VF VF
Sbjct: 1214 NPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAM-QHY--EQSKMFNDAMDILNMVFTGVF 1270
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMS----IQGFDVKALR 570
T+E VLK++A F P Y +AWN D +IV+ ++ LS+ + R
Sbjct: 1271 TVEMVLKVIA----FKPKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFFR 1326
Query: 571 AFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHST 750
FRV+R ++L+S ++ +L +++ L ++ALL+ + IYA+IG+++F
Sbjct: 1327 LFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMF------- 1379
Query: 751 CIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFD 930
G++A +D N NF
Sbjct: 1380 ------GKVAMRDNNQI------------------------------------NRNNNFQ 1397
Query: 931 NFGLAMLTVFQCVSLEGWTDVMY----------------WVNDAVGREWPWIYFVTLVIL 1062
F A+L +F+C + E W ++M G + +YF++ +L
Sbjct: 1398 TFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPDSDYNPGEEYTCGSNFAIVYFISFYML 1457
Query: 1063 GSFFVLNLVLGVLSGEF 1113
+F ++NL + V+ F
Sbjct: 1458 CAFLIINLFVAVIMDNF 1474
Score = 92.4 bits (228), Expect = 1e-16
Identities = 146/706 (20%), Positives = 255/706 (35%), Gaps = 80/706 (11%)
Frame = +1
Query: 232 RKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIE 411
R+ C + V+ F +L++ ++ N + ++ D+ + + V + +FT E
Sbjct: 535 RRRCRAAVKSVTFYWLVIVLVFLNTLTISSEH---YNQPDWLTQIQDIANKVLLALFTCE 591
Query: 412 CVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG-FDVKALRAFRVLR 588
++K+ ++G AY + +N D +V G+ TIL ++ + V R R+LR
Sbjct: 592 MLVKMYSLGLQ----AYFVSLFNRFDCFVVCGGITETILVELELMSPLGVSVFRCVRLLR 647
Query: 589 PLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPAT 768
++ SL ++ ++L +M + + LL+ I+I++++
Sbjct: 648 IFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLL------------------ 689
Query: 769 GQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAM 948
G G F + + + FDNF A+
Sbjct: 690 -----------GMQLFGGKFNFDETQTKRS---------------------TFDNFPQAL 717
Query: 949 LTVFQCVSLEGWTDVMYWVNDAVGREWP-----WIYFVTLVILGSFFVLNLVLGVLSGEF 1113
LTVFQ ++ E W VMY A G IYF+ L I G++ +LN+ L +
Sbjct: 718 LTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNL 777
Query: 1114 S---------------KEREK-ARARGLFQKFREKQQLEE----DLKGYLD-WITQAEDI 1230
+ KER+K AR L K K ++ + D K +D + AED
Sbjct: 778 ADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYQEDAEDK 837
Query: 1231 EPV----------NEDEQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNX 1380
+P E+E+EDEP P + L K N
Sbjct: 838 DPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRTSELNMKEKIA-PIPEGSAFFILSKTNP 896
Query: 1381 XXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSE-----HYGQSEWLDHFQTMANLFFVIL 1545
L+ F +E H ++ L +F + F +
Sbjct: 897 IRVGCHK-LINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYF----DYAFTAI 951
Query: 1546 FSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSA 1713
F++E+LLKM + G + + FN D VV S++ F + + V +LR
Sbjct: 952 FTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISV---VKILRVL 1008
Query: 1714 RLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF----- 1878
R+LR + G+Q+F GKF
Sbjct: 1009 RVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTD 1068
Query: 1879 --NFNPQQ---------------PKPRA--------NFDTFVQALLTVFQILTGEDWNTV 1983
NP++ P R NFD + A++ +F + T E W +
Sbjct: 1069 EAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPAL 1128
Query: 1984 MYHGI----ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+Y I E+ G V V + I++I+ I + ++N+F+ +
Sbjct: 1129 LYKAIDSNGENVGPVYNYRVEISIFFIIYIIIVAFFMMNIFVGFVI 1174
Score = 88.6 bits (218), Expect = 2e-15
Identities = 79/290 (27%), Positives = 121/290 (41%), Gaps = 39/290 (13%)
Frame = +1
Query: 2323 ASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPL---QANSTRNMIL 2493
A +LF LS N R C +V F +L I + LA P +NST N L
Sbjct: 125 ARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNST-NHNL 183
Query: 2494 NYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL-----RT 2658
+Y F +FTVE LK+I +GL+ H ++ RN +NLLD ++V V L S +L T
Sbjct: 184 EKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKET 243
Query: 2659 DAMSXXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFML 2811
+ + A ++ L+ V+ +I A+ + +I L+ +
Sbjct: 244 EGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFV 303
Query: 2812 QFMFAIIGVQLF-----KGTFFLCNDLSKMTE-----------------AECRGEYIHYE 2925
++AIIG++LF K FF +D+ + ECR ++
Sbjct: 304 IIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPN 363
Query: 2926 DGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
G NFDN AM+++F T EGW +LY D+
Sbjct: 364 GGIT---------------NFDNFAFAMLTVFQCITMEGWTDVLYWVNDA 398
Score = 84.0 bits (206), Expect = 4e-14
Identities = 81/352 (23%), Positives = 141/352 (40%), Gaps = 53/352 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ F+ I L I N V+LA +P S L+ F +F E LKI+A
Sbjct: 148 KPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGL 207
Query: 3511 -LNPKNYISDRWNVFDLLVVVGSFIDITYGKL---------NPGGTNLISINFFRLFRVM 3660
L+P Y+ + WN+ D ++V+ + +L + G + + R FRV+
Sbjct: 208 LLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVL 267
Query: 3661 RLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF------------ 3804
R ++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F
Sbjct: 268 RPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFAD 327
Query: 3805 -----------------GKVALDDSTSIHRN--------NNFHSFPAAILVLFRSATGEA 3909
G+ + T NF +F A+L +F+ T E
Sbjct: 328 SDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEG 387
Query: 3910 WQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAV 4089
W D++ +D G + + YF+S +L SF V+NL + V
Sbjct: 388 WTDVLYWVND---------------------AIGWEWPWVYFVSLIILGSFFVLNLVLGV 426
Query: 4090 IMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
+ F G + +R + + D KG +LD +T + I P
Sbjct: 427 LSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQVEDIDP 472
Score = 74.3 bits (181), Expect = 3e-11
Identities = 53/230 (23%), Positives = 98/230 (42%), Gaps = 17/230 (7%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HY QS+ + + N+ F +F++EM+LK+ + Y + +N FD +VI SI++
Sbjct: 1247 QHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDV 1306
Query: 1657 VLVYFDLMKP---LGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXX 1827
L D + + ++ R R++R+ K+
Sbjct: 1307 ALSEADNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAM 1366
Query: 1828 XXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVM------- 1986
GMQ+FG + Q NF TF QA+L +F+ TGE W +M
Sbjct: 1367 LFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGK 1426
Query: 1987 -------YHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDN 2115
Y+ E + + +Y+I ++ ++++N+F+A+ +DN
Sbjct: 1427 LCDPDSDYNPGEEYTCGSNFAI---VYFISFYMLCAFLIINLFVAVIMDN 1473
>gi|20338999|emb|CAD26883.1| L-type voltage-gated calcium channel
Cav1.3(1a) subunit [Mus musculus]
Length = 2144
Score = 1056 bits (2731), Expect = 0.0
Identities = 544/933 (58%), Positives = 679/933 (72%), Gaps = 11/933 (1%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPRR SE+ + PIP+ S+ FILS TN RV C+ ++NH FTN +L I++SSA L
Sbjct: 844 RPRRTSELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAAL 903
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP++++S RN IL YFDY FT++FTVEI LK+ FG HKG+FCRN FNLLD+LVV
Sbjct: 904 AAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVV 963
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
VSL SF +++ A+S AINRAKGLKHVVQCV VA++TIGNIM+VT
Sbjct: 964 GVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTT 1023
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG F+ C D +K ECRG +I Y+DGD PV ++R+W N+DFN
Sbjct: 1024 LLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFN 1083
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP LLY AIDSN E+ GP++N R +++
Sbjct: 1084 FDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENVGPVYNYRVEISIFFIIYIIIVAFFM 1143
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N QY+ W+ V
Sbjct: 1144 MNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVN 1203
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S+ F D +D+ N++FTGVF E VLK++A PK
Sbjct: 1204 SSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKG 1263
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKL-NPGGTNLISINFFRLFRVMRLVKLLSRGEGIRT 3702
Y SD WN FD L+V+GS ID+ + N +N ISI FFRLFRVMRLVKLLSRGEGIRT
Sbjct: 1264 YFSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFFRLFRVMRLVKLLSRGEGIRT 1323
Query: 3703 LLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILV 3882
LLWTF+KSFQALPYVALLI +LFFIYAVIGMQ FGKVA+ D+ I+RNNNF +FP A+L+
Sbjct: 1324 LLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLL 1383
Query: 3883 LFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSF 4062
LFR ATGEAWQ+IML+C + CDP SD Y+ G E CG+NFA YFISF+MLC+F
Sbjct: 1384 LFRCATGEAWQEIMLACLPGK--LCDPDSD-YNPG--EEYTCGSNFAIVYFISFYMLCAF 1438
Query: 4063 LVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKIS 4242
L+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+WSEYDP+AKGRIKHLDVVTLLR+I
Sbjct: 1439 LIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQ 1498
Query: 4243 PPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNIDEANEQL 4422
PPLGFGKLCPHR+ACKRLV+MNMPLNSDGTV FNATLFALVRT LKI TEGN+++ANE+L
Sbjct: 1499 PPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEEL 1558
Query: 4423 RSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEMEAKGVLP 4602
R+ IK+IWK+T LLD+VVPPAG +D+VTVGKFYATFLIQDYFR+FKKRKE G P
Sbjct: 1559 RAVIKKIWKKTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYP 1617
Query: 4603 AQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFD---EPEPQHRRPHSLFNNLVHR 4773
A+ +ALQAGLRTLH+IGPE++RAIS +L+ D D E E +R +L N V+
Sbjct: 1618 AKN-TTIALQAGLRTLHDIGPEIRRAISCDLQDDEPEDSKPEEEDVFKRNGALLGNHVNH 1676
Query: 4774 LSG----AGSKSPTEHERIEKGSTLLPFQPRSFSPTHSLAGAEG---SPVPSQMHRGAPI 4932
++ + ++ T H + +P + P AG G + + + AP
Sbjct: 1677 VNSDRRDSLQQTNTTHRPLHVQRPSMPPASDTEKPLFPPAGNSGCHNHHNHNSIGKQAPT 1736
Query: 4933 NQSINLPPVNGSARRLPALPPYANHIHDETDDG 5031
+ + NL N S + PP ++ +++G
Sbjct: 1737 STNANLNNANMS-KAAHGKPPSIGNLEHVSENG 1768
Score = 722 bits (1864), Expect = 0.0
Identities = 376/669 (56%), Positives = 449/669 (66%), Gaps = 27/669 (4%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
NNPIR+ CISIVEWKPF+ IL I ANC+ALAIY P+P DS+ N LE +EY F+++
Sbjct: 112 NNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLII 171
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQ----------- 546
FT+E LKI+A G + HP+AY+RN WN+LDF+IV++GL S IL +++ +
Sbjct: 172 FTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKS 231
Query: 547 -GFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLE 723
GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+I++AM+PLLHIALLVLFVI+IYAIIGLE
Sbjct: 232 GGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLE 291
Query: 724 LFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPG 903
LF GK+H TC + +A++DP PC G+ +C + + EC S W G
Sbjct: 292 LFIGKMHKTCFFADSDIVAEEDPAPCAFS--GNGRQCTANGT--------ECRSG--WVG 339
Query: 904 PNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLN 1083
PN GITNFDNF AMLTVFQC+++EGWTDV+YWVNDA+G EWPW+YFV+L+ILGSFFVLN
Sbjct: 340 PNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLN 399
Query: 1084 LVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDE 1263
LVLGVLSGEFSKEREKA+ARG FQK REKQQLEEDLKGYLDWITQ EDI+P NE+E +E
Sbjct: 400 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQVEDIDPENEEEGGEE 459
Query: 1264 -------PVAQTXXXXXXXXXXXXXX--------XXXXPSKWAARMKRLEKLNXXXXXXX 1398
P ++T SK + R +R + N
Sbjct: 460 GKRNTSMPTSETESVNTENVSGEGETQGCCGTLCQAISKSKLSRRWRRWNRFNRRRCRAA 519
Query: 1399 XXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYS 1578
VKS TFYW +SEHY Q +WL Q +AN + LF+ EML+KMYS
Sbjct: 520 ---VKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYS 576
Query: 1579 LGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXX 1758
LG Y S FNRFDCFVV I E +LV +LM PLGVSV R RLLRIFKVT++WT
Sbjct: 577 LGLQAYFVSLFNRFDCFVVCGGITETILVELELMSPLGVSVFRCVRLLRIFKVTRHWTSL 636
Query: 1759 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQAL 1938
GMQ+FGGKFNF+ Q K R+ FD F QAL
Sbjct: 637 SNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTK-RSTFDNFPQAL 695
Query: 1939 LTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNL 2118
LTVFQILTGEDWN VMY GI ++GG + G+IVCIY+I+LFICGNYILLNVFLAIAVDNL
Sbjct: 696 LTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNL 755
Query: 2119 ADADSLTNA 2145
ADA+SL A
Sbjct: 756 ADAESLNTA 764
Score = 128 bits (322), Expect = 1e-27
Identities = 92/312 (29%), Positives = 152/312 (48%), Gaps = 9/312 (2%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR C ++ F LIL I + ALA P + ++NT+L +Y F +F
Sbjct: 873 NPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPI--RSHSFRNTILGYFDYAFTAIF 930
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
T+E +LK+ G H A+ RN +N+LD ++V + LVS + +I VK LR RV
Sbjct: 931 TVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAIS--VVKILRVLRV 988
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLR ++ L+ V+ + A+ + +I ++ + ++A IG++LF GK + C D
Sbjct: 989 LRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFY-RCTDE 1047
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
A+ +P C F + + VR N+ + NFDN
Sbjct: 1048 -----AKSNPEEC-----RGLFILYKDGDVDSPVVRERIWQNSDF--------NFDNVLS 1089
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDAVG---------REWPWIYFVTLVILGSFFVLNLVLG 1095
AM+ +F + EGW ++Y D+ G R I+F+ +I+ +FF++N+ +G
Sbjct: 1090 AMMALFTVSTFEGWPALLYKAIDSNGENVGPVYNYRVEISIFFIIYIIIVAFFMMNIFVG 1149
Query: 1096 VLSGEFSKEREK 1131
+ F ++ EK
Sbjct: 1150 FVIVTFQEQGEK 1161
Score = 102 bits (255), Expect = 8e-20
Identities = 70/276 (25%), Positives = 134/276 (48%), Gaps = 1/276 (0%)
Frame = +1
Query: 3277 KAKPHRRYIPRNRL-QYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDV 3453
K+K RR+ NR + R V S F +++ +++ +NT++++ +HY D+
Sbjct: 498 KSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDI 557
Query: 3454 FNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISI 3633
N + +F E ++K+ +L + Y +N FD VV G + +L + + +
Sbjct: 558 ANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEL--MSPLGV 615
Query: 3634 NFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKV 3813
+ FR R++R+ K+ + L+ + + S +++ + LL+ L I++++GMQ FG
Sbjct: 616 SVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGK 675
Query: 3814 ALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGL 3993
D T R+ F +FP A+L +F+ TGE W +M GG
Sbjct: 676 FNFDETQTKRST-FDNFPQALLTVFQILTGEDWNAVMYD-------------GIMAYGGP 721
Query: 3994 NESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDN 4101
+ S YFI F+ +++++N+F+A+ +DN
Sbjct: 722 SSS---GMIVCIYFIILFICGNYILLNVFLAIAVDN 754
Score = 99.0 bits (245), Expect = 1e-18
Identities = 76/317 (23%), Positives = 135/317 (41%), Gaps = 20/317 (6%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP + +V PFE+++ +I N + LA+ Q Y + S N ++ + VF VF
Sbjct: 1192 NPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAM-QHY--EQSKMFNDAMDILNMVFTGVF 1248
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMS----IQGFDVKALR 570
T+E VLK++A F P Y +AWN D +IV+ ++ LS+ + R
Sbjct: 1249 TVEMVLKVIA----FKPKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFFR 1304
Query: 571 AFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHST 750
FRV+R ++L+S ++ +L +++ L ++ALL+ + IYA+IG+++F
Sbjct: 1305 LFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMF------- 1357
Query: 751 CIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFD 930
G++A +D N NF
Sbjct: 1358 ------GKVAMRDNNQI------------------------------------NRNNNFQ 1375
Query: 931 NFGLAMLTVFQCVSLEGWTDVMY----------------WVNDAVGREWPWIYFVTLVIL 1062
F A+L +F+C + E W ++M G + +YF++ +L
Sbjct: 1376 TFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPDSDYNPGEEYTCGSNFAIVYFISFYML 1435
Query: 1063 GSFFVLNLVLGVLSGEF 1113
+F ++NL + V+ F
Sbjct: 1436 CAFLIINLFVAVIMDNF 1452
Score = 92.4 bits (228), Expect = 1e-16
Identities = 146/706 (20%), Positives = 255/706 (35%), Gaps = 80/706 (11%)
Frame = +1
Query: 232 RKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIE 411
R+ C + V+ F +L++ ++ N + ++ D+ + + V + +FT E
Sbjct: 513 RRRCRAAVKSVTFYWLVIVLVFLNTLTISSEH---YNQPDWLTQIQDIANKVLLALFTCE 569
Query: 412 CVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG-FDVKALRAFRVLR 588
++K+ ++G AY + +N D +V G+ TIL ++ + V R R+LR
Sbjct: 570 MLVKMYSLGLQ----AYFVSLFNRFDCFVVCGGITETILVELELMSPLGVSVFRCVRLLR 625
Query: 589 PLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPAT 768
++ SL ++ ++L +M + + LL+ I+I++++
Sbjct: 626 IFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLL------------------ 667
Query: 769 GQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAM 948
G G F + + + FDNF A+
Sbjct: 668 -----------GMQLFGGKFNFDETQTKRS---------------------TFDNFPQAL 695
Query: 949 LTVFQCVSLEGWTDVMYWVNDAVGREWP-----WIYFVTLVILGSFFVLNLVLGVLSGEF 1113
LTVFQ ++ E W VMY A G IYF+ L I G++ +LN+ L +
Sbjct: 696 LTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNL 755
Query: 1114 S---------------KEREK-ARARGLFQKFREKQQLEE----DLKGYLD-WITQAEDI 1230
+ KER+K AR L K K ++ + D K +D + AED
Sbjct: 756 ADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYQEDAEDK 815
Query: 1231 EPV----------NEDEQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNX 1380
+P E+E+EDEP P + L K N
Sbjct: 816 DPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRTSELNMKEKIA-PIPEGSAFFILSKTNP 874
Query: 1381 XXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSE-----HYGQSEWLDHFQTMANLFFVIL 1545
L+ F +E H ++ L +F + F +
Sbjct: 875 IRVGCHK-LINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYF----DYAFTAI 929
Query: 1546 FSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSA 1713
F++E+LLKM + G + + FN D VV S++ F + + V +LR
Sbjct: 930 FTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISV---VKILRVL 986
Query: 1714 RLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF----- 1878
R+LR + G+Q+F GKF
Sbjct: 987 RVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTD 1046
Query: 1879 --NFNPQQ---------------PKPRA--------NFDTFVQALLTVFQILTGEDWNTV 1983
NP++ P R NFD + A++ +F + T E W +
Sbjct: 1047 EAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPAL 1106
Query: 1984 MYHGI----ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+Y I E+ G V V + I++I+ I + ++N+F+ +
Sbjct: 1107 LYKAIDSNGENVGPVYNYRVEISIFFIIYIIIVAFFMMNIFVGFVI 1152
Score = 88.6 bits (218), Expect = 2e-15
Identities = 79/290 (27%), Positives = 121/290 (41%), Gaps = 39/290 (13%)
Frame = +1
Query: 2323 ASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPL---QANSTRNMIL 2493
A +LF LS N R C +V F +L I + LA P +NST N L
Sbjct: 103 ARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNST-NHNL 161
Query: 2494 NYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL-----RT 2658
+Y F +FTVE LK+I +GL+ H ++ RN +NLLD ++V V L S +L T
Sbjct: 162 EKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKET 221
Query: 2659 DAMSXXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFML 2811
+ + A ++ L+ V+ +I A+ + +I L+ +
Sbjct: 222 EGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFV 281
Query: 2812 QFMFAIIGVQLF-----KGTFFLCNDLSKMTE-----------------AECRGEYIHYE 2925
++AIIG++LF K FF +D+ + ECR ++
Sbjct: 282 IIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPN 341
Query: 2926 DGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
G NFDN AM+++F T EGW +LY D+
Sbjct: 342 GGIT---------------NFDNFAFAMLTVFQCITMEGWTDVLYWVNDA 376
Score = 84.0 bits (206), Expect = 4e-14
Identities = 81/352 (23%), Positives = 141/352 (40%), Gaps = 53/352 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ F+ I L I N V+LA +P S L+ F +F E LKI+A
Sbjct: 126 KPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGL 185
Query: 3511 -LNPKNYISDRWNVFDLLVVVGSFIDITYGKL---------NPGGTNLISINFFRLFRVM 3660
L+P Y+ + WN+ D ++V+ + +L + G + + R FRV+
Sbjct: 186 LLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVL 245
Query: 3661 RLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF------------ 3804
R ++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F
Sbjct: 246 RPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFAD 305
Query: 3805 -----------------GKVALDDSTSIHRN--------NNFHSFPAAILVLFRSATGEA 3909
G+ + T NF +F A+L +F+ T E
Sbjct: 306 SDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEG 365
Query: 3910 WQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAV 4089
W D++ +D G + + YF+S +L SF V+NL + V
Sbjct: 366 WTDVLYWVND---------------------AIGWEWPWVYFVSLIILGSFFVLNLVLGV 404
Query: 4090 IMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
+ F G + +R + + D KG +LD +T + I P
Sbjct: 405 LSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQVEDIDP 450
Score = 74.3 bits (181), Expect = 3e-11
Identities = 53/230 (23%), Positives = 98/230 (42%), Gaps = 17/230 (7%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HY QS+ + + N+ F +F++EM+LK+ + Y + +N FD +VI SI++
Sbjct: 1225 QHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDV 1284
Query: 1657 VLVYFDLMKP---LGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXX 1827
L D + + ++ R R++R+ K+
Sbjct: 1285 ALSEADNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAM 1344
Query: 1828 XXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVM------- 1986
GMQ+FG + Q NF TF QA+L +F+ TGE W +M
Sbjct: 1345 LFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGK 1404
Query: 1987 -------YHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDN 2115
Y+ E + + +Y+I ++ ++++N+F+A+ +DN
Sbjct: 1405 LCDPDSDYNPGEEYTCGSNFAI---VYFISFYMLCAFLIINLFVAVIMDN 1451
>gi|8393030|ref|NP_058994.1| calcium channel, voltage-dependent, L
type, alpha 1D subunit; CaV1.3alpha1 [Rattus norvegicus]
gi|6165987|sp|P27732|CCAD_RAT Voltage-dependent L-type calcium
channel alpha-1D subunit (Voltage-gated calcium channel
alpha subunit Cav1.3) (Calcium channel, L type, alpha-1
polypeptide, isoform 2) (RAT brain class D) (RBD)
gi|11279257|pir||T42742 voltage-dependent calcium channel alpha 1
chain, isoform CACN4A - rat
gi|736712|dbj|BAA07282.1| L-type voltage-dependent calcium channel
alpha 1 subunit [Rattus norvegicus]
Length = 2203
Score = 1055 bits (2729), Expect = 0.0
Identities = 528/842 (62%), Positives = 647/842 (76%), Gaps = 4/842 (0%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPRR+SE+ + PIP+ S+ FILS TN RV C+ ++NH FTN +L I++SSA L
Sbjct: 903 RPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAAL 962
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP++++S RN IL YFDY FT++FTVEI LK+ FG HKG+FCRN FNLLD+LVV
Sbjct: 963 AAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVV 1022
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
VSL SF +++ A+S AINRAKGLKHVVQCV VA++TIGNIM+VT
Sbjct: 1023 GVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTT 1082
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG F+ C D +K ECRG +I Y+DGD PV ++R+W N+DFN
Sbjct: 1083 LLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFN 1142
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP LLY AIDSN E+ GP++N R +++
Sbjct: 1143 FDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENVGPVYNYRVEISIFFIIYIIIVAFFM 1202
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N QY+ W+ V
Sbjct: 1203 MNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVN 1262
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S+ F D +D+ N++FTGVF E VLK++A PK
Sbjct: 1263 SSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKG 1322
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKL-NPGGTNLISINFFRLFRVMRLVKLLSRGEGIRT 3702
Y SD WN FD L+V+GS ID+ + N +N ISI FFRLFRVMRLVKLLSRGEGIRT
Sbjct: 1323 YFSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFFRLFRVMRLVKLLSRGEGIRT 1382
Query: 3703 LLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILV 3882
LLWTF+KSFQALPYVALLI +LFFIYAVIGMQ FGKVA+ D+ I+RNNNF +FP A+L+
Sbjct: 1383 LLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLL 1442
Query: 3883 LFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSF 4062
LFR ATGEAWQ+IML+C + CDP SD Y+ G E CG+NFA YFISF+MLC+F
Sbjct: 1443 LFRCATGEAWQEIMLACLPGK--LCDPDSD-YNPG--EEYTCGSNFAIVYFISFYMLCAF 1497
Query: 4063 LVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKIS 4242
L+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+WSEYDP+AKGRIKHLDVVTLLR+I
Sbjct: 1498 LIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQ 1557
Query: 4243 PPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNIDEANEQL 4422
PPLGFGKLCPHR+ACKRLV+MNMPLNSDGTV FNATLFALVRT LKI TEGN+++ANE+L
Sbjct: 1558 PPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEEL 1617
Query: 4423 RSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEMEAKGVLP 4602
R+ IK+IWK+T LLD+VVPPAG +D+VTVGKFYATFLIQDYFR+FKKRKE G P
Sbjct: 1618 RAVIKKIWKKTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYP 1676
Query: 4603 AQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFD---EPEPQHRRPHSLFNNLVHR 4773
A+ +ALQAGLRTLH+IGPE++RAIS +L+ D D E E +R +L N V+
Sbjct: 1677 AKN-TTIALQAGLRTLHDIGPEIRRAISCDLQDDEPEDSKPEEEDVFKRNGALLGNYVNH 1735
Query: 4774 LS 4779
++
Sbjct: 1736 VN 1737
Score = 473 bits (1216), Expect = e-131
Identities = 232/360 (64%), Positives = 281/360 (77%), Gaps = 12/360 (3%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
NNPIR+ CISIV+WKPF+ IL I ANC+ALAIY P+P DS+ N LE +EY F+++
Sbjct: 112 NNPIRRACISIVDWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLII 171
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQ----------- 546
FT+E LKI+A G + HP+A +RN WN+LDF+IV++GL S IL +++ +
Sbjct: 172 FTVETFLKIIASGLLLHPNASVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKS 231
Query: 547 -GFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLE 723
GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+I++AM+PLLHIALLVLFVI+IYAIIGLE
Sbjct: 232 GGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLE 291
Query: 724 LFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPG 903
LF GK+H TC + +A++DP PC G+ +C + + EC S W G
Sbjct: 292 LFIGKMHKTCFFADSDIVAEEDPAPCAFS--GNGRQCAANGT--------ECRSG--WVG 339
Query: 904 PNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLN 1083
PN GITNFDNF AMLTVFQC+++EGWTDV+YWVNDA+G EWPW+YFV+L+ILGSFFVLN
Sbjct: 340 PNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLN 399
Query: 1084 LVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDE 1263
LVLGVLSGEFSKEREKA+ARG FQK REKQQLEEDLKGYLDWITQAEDI+P NE+E +E
Sbjct: 400 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEE 459
Score = 259 bits (663), Expect = 4e-67
Identities = 136/263 (51%), Positives = 159/263 (59%)
Frame = +1
Query: 1357 KRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFF 1536
+R + N VKS TFYW +SEHY Q +WL Q +AN
Sbjct: 562 RRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVL 621
Query: 1537 VILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSAR 1716
+ LF+ EML+KMYSLG Y S FNRFDCFVV I E +LV +LM PLGVSV R R
Sbjct: 622 LALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELELMSPLGVSVFRCVR 681
Query: 1717 LLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQ 1896
LLRIFKVT++WT GMQ+FGGKFNF+ Q
Sbjct: 682 LLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQ 741
Query: 1897 PKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNY 2076
K R+ FD F QALLTVFQILTGEDWN VMY GI ++GG + G+IVCIY+I+LFICGNY
Sbjct: 742 TK-RSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNY 800
Query: 2077 ILLNVFLAIAVDNLADADSLTNA 2145
ILL +FLAIAVDNLADA+SL A
Sbjct: 801 ILLKLFLAIAVDNLADAESLNTA 823
Score = 128 bits (322), Expect = 1e-27
Identities = 92/312 (29%), Positives = 152/312 (48%), Gaps = 9/312 (2%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR C ++ F LIL I + ALA P + ++NT+L +Y F +F
Sbjct: 932 NPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPI--RSHSFRNTILGYFDYAFTAIF 989
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
T+E +LK+ G H A+ RN +N+LD ++V + LVS + +I VK LR RV
Sbjct: 990 TVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAIS--VVKILRVLRV 1047
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLR ++ L+ V+ + A+ + +I ++ + ++A IG++LF GK + C D
Sbjct: 1048 LRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFY-RCTDE 1106
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
A+ +P C F + + VR N+ + NFDN
Sbjct: 1107 -----AKSNPEEC-----RGLFILYKDGDVDSPVVRERIWQNSDF--------NFDNVLS 1148
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDAVG---------REWPWIYFVTLVILGSFFVLNLVLG 1095
AM+ +F + EGW ++Y D+ G R I+F+ +I+ +FF++N+ +G
Sbjct: 1149 AMMALFTVSTFEGWPALLYKAIDSNGENVGPVYNYRVEISIFFIIYIIIVAFFMMNIFVG 1208
Query: 1096 VLSGEFSKEREK 1131
+ F ++ EK
Sbjct: 1209 FVIVTFQEQGEK 1220
Score = 100 bits (249), Expect = 4e-19
Identities = 68/270 (25%), Positives = 130/270 (47%)
Frame = +1
Query: 3292 RRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFT 3471
RR+ NR + R V S F +++ +++ +NT++++ +HY D+ N +
Sbjct: 565 RRWNRFNRRRCRA--AVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLL 622
Query: 3472 GVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLF 3651
+F E ++K+ +L + Y +N FD VV G + +L + + ++ FR
Sbjct: 623 ALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEL--MSPLGVSVFRCV 680
Query: 3652 RVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDST 3831
R++R+ K+ + L+ + + S +++ + LL+ L I++++GMQ FG D T
Sbjct: 681 RLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDET 740
Query: 3832 SIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCG 4011
R + F +FP A+L +F+ TGE W +M GG + S
Sbjct: 741 QTKR-STFDNFPQALLTVFQILTGEDWNAVM-------------YDGIMAYGGPSSS--- 783
Query: 4012 NNFAYPYFISFFMLCSFLVINLFVAVIMDN 4101
YFI F+ +++++ LF+A+ +DN
Sbjct: 784 GMIVCIYFIILFICGNYILLKLFLAIAVDN 813
Score = 99.0 bits (245), Expect = 1e-18
Identities = 76/317 (23%), Positives = 135/317 (41%), Gaps = 20/317 (6%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP + +V PFE+++ +I N + LA+ Q Y + S N ++ + VF VF
Sbjct: 1251 NPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAM-QHY--EQSKMFNDAMDILNMVFTGVF 1307
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMS----IQGFDVKALR 570
T+E VLK++A F P Y +AWN D +IV+ ++ LS+ + R
Sbjct: 1308 TVEMVLKVIA----FKPKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFFR 1363
Query: 571 AFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHST 750
FRV+R ++L+S ++ +L +++ L ++ALL+ + IYA+IG+++F
Sbjct: 1364 LFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMF------- 1416
Query: 751 CIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFD 930
G++A +D N NF
Sbjct: 1417 ------GKVAMRDNNQI------------------------------------NRNNNFQ 1434
Query: 931 NFGLAMLTVFQCVSLEGWTDVMY----------------WVNDAVGREWPWIYFVTLVIL 1062
F A+L +F+C + E W ++M G + +YF++ +L
Sbjct: 1435 TFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPDSDYNPGEEYTCGSNFAIVYFISFYML 1494
Query: 1063 GSFFVLNLVLGVLSGEF 1113
+F ++NL + V+ F
Sbjct: 1495 CAFLIINLFVAVIMDNF 1511
Score = 91.7 bits (226), Expect = 2e-16
Identities = 146/706 (20%), Positives = 255/706 (35%), Gaps = 80/706 (11%)
Frame = +1
Query: 232 RKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIE 411
R+ C + V+ F +L++ ++ N + ++ D+ + + V + +FT E
Sbjct: 572 RRRCRAAVKSVTFYWLVIVLVFLNTLTISSEH---YNQPDWLTQIQDIANKVLLALFTCE 628
Query: 412 CVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG-FDVKALRAFRVLR 588
++K+ ++G AY + +N D +V G+ TIL ++ + V R R+LR
Sbjct: 629 MLVKMYSLGLQ----AYFVSLFNRFDCFVVCGGITETILVELELMSPLGVSVFRCVRLLR 684
Query: 589 PLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPAT 768
++ SL ++ ++L +M + + LL+ I+I++++
Sbjct: 685 IFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLL------------------ 726
Query: 769 GQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAM 948
G G F + + + FDNF A+
Sbjct: 727 -----------GMQLFGGKFNFDETQTKRS---------------------TFDNFPQAL 754
Query: 949 LTVFQCVSLEGWTDVMYWVNDAVGREWP-----WIYFVTLVILGSFFVLNLVLGVLSGEF 1113
LTVFQ ++ E W VMY A G IYF+ L I G++ +L L L +
Sbjct: 755 LTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLKLFLAIAVDNL 814
Query: 1114 S---------------KEREK-ARARGLFQKFREKQQLEE----DLKGYL-DWITQAEDI 1230
+ KER+K AR L K K ++ + D K + D+ +AED
Sbjct: 815 ADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYQEEAEDK 874
Query: 1231 EPV----------NEDEQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNX 1380
+P E+E+EDEP P + L K N
Sbjct: 875 DPYPPCDVPVGEEEEEEEEDEPEV-PAGPRPRRISELNMKEKIAPIPEGSAFFILSKTN- 932
Query: 1381 XXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSE-----HYGQSEWLDHFQTMANLFFVIL 1545
L+ F +E H ++ L +F + F +
Sbjct: 933 PIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYF----DYAFTAI 988
Query: 1546 FSMEMLLKMYSLGF----TTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSA 1713
F++E+LLKM + G + + FN D VV S++ F + + V +LR
Sbjct: 989 FTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISV---VKILRVL 1045
Query: 1714 RLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF----- 1878
R+LR + G+Q+F GKF
Sbjct: 1046 RVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTD 1105
Query: 1879 --NFNPQQ---------------PKPRA--------NFDTFVQALLTVFQILTGEDWNTV 1983
NP++ P R NFD + A++ +F + T E W +
Sbjct: 1106 EAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPAL 1165
Query: 1984 MYHGI----ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+Y I E+ G V V + I++I+ I + ++N+F+ +
Sbjct: 1166 LYKAIDSNGENVGPVYNYRVEISIFFIIYIIIVAFFMMNIFVGFVI 1211
Score = 85.9 bits (211), Expect = 1e-14
Identities = 79/275 (28%), Positives = 120/275 (42%), Gaps = 24/275 (8%)
Frame = +1
Query: 2323 ASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPL---QANSTRNMIL 2493
A +LF LS N R C +V+ F +L I + LA P +NST N L
Sbjct: 103 ARALFCLSLNNPIRRACISIVDWKPFDIFILLAIFANCVALAIYIPFPEDDSNST-NHNL 161
Query: 2494 NYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL-----RT 2658
+Y F +FTVE LK+I GL+ H + RN +NLLD ++V V L S +L T
Sbjct: 162 EKVEYAFLIIFTVETFLKIIASGLLLHPNASVRNGWNLLDFVIVIVGLFSVILEQLTKET 221
Query: 2659 DAMSXXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFML 2811
+ + A ++ L+ V+ +I A+ + +I L+ +
Sbjct: 222 EGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFV 281
Query: 2812 QFMFAIIGVQLF-----KGTFFLCNDL-SKMTEAECRGEYIHYEDGDPTKPVSKKRVWSN 2973
++AIIG++LF K FF +D+ ++ A C + V N
Sbjct: 282 IIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCAANGTECRSGWVGPN 341
Query: 2974 NDF-NFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
NFDN AM+++F T EGW +LY D+
Sbjct: 342 GGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDA 376
Score = 79.7 bits (195), Expect = 7e-13
Identities = 80/352 (22%), Positives = 139/352 (38%), Gaps = 53/352 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ F+ I L I N V+LA +P S L+ F +F E LKI+A
Sbjct: 126 KPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIASGL 185
Query: 3511 -LNPKNYISDRWNVFDLLVVVGSFIDITYGKL---------NPGGTNLISINFFRLFRVM 3660
L+P + + WN+ D ++V+ + +L + G + + R FRV+
Sbjct: 186 LLHPNASVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVL 245
Query: 3661 RLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF------------ 3804
R ++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F
Sbjct: 246 RPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFAD 305
Query: 3805 -----------------GKVALDDSTSIHRN--------NNFHSFPAAILVLFRSATGEA 3909
G+ + T NF +F A+L +F+ T E
Sbjct: 306 SDIVAEEDPAPCAFSGNGRQCAANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEG 365
Query: 3910 WQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAV 4089
W D++ +D G + + YF+S +L SF V+NL + V
Sbjct: 366 WTDVLYWVND---------------------AIGWEWPWVYFVSLIILGSFFVLNLVLGV 404
Query: 4090 IMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
+ F G + +R + + D KG +LD +T I P
Sbjct: 405 LSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 450
Score = 74.3 bits (181), Expect = 3e-11
Identities = 53/230 (23%), Positives = 98/230 (42%), Gaps = 17/230 (7%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HY QS+ + + N+ F +F++EM+LK+ + Y + +N FD +VI SI++
Sbjct: 1284 QHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDV 1343
Query: 1657 VLVYFDLMKP---LGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXX 1827
L D + + ++ R R++R+ K+
Sbjct: 1344 ALSEADNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAM 1403
Query: 1828 XXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVM------- 1986
GMQ+FG + Q NF TF QA+L +F+ TGE W +M
Sbjct: 1404 LFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGK 1463
Query: 1987 -------YHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDN 2115
Y+ E + + +Y+I ++ ++++N+F+A+ +DN
Sbjct: 1464 LCDPDSDYNPGEEYTCGSNFAI---VYFISFYMLCAFLIINLFVAVIMDN 1510
Score = 45.4 bits (106), Expect = 0.016
Identities = 23/64 (35%), Positives = 36/64 (55%)
Frame = +1
Query: 1912 NFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNV 2091
NFD F A+LTVFQ +T E W V+Y ++ G +Y++ L I G++ +LN+
Sbjct: 346 NFDNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWP-----WVYFVSLIILGSFFVLNL 400
Query: 2092 FLAI 2103
L +
Sbjct: 401 VLGV 404
>gi|31414559|dbj|BAC77259.1| calcium channel alpha 1D subunit [Mus
musculus]
Length = 2179
Score = 1053 bits (2723), Expect = 0.0
Identities = 544/948 (57%), Positives = 681/948 (71%), Gaps = 26/948 (2%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPRR+SE+ + PIP+ S+ FILS TN RV C+ ++NH FTN +L I++SSA L
Sbjct: 864 RPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAAL 923
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP++++S RN IL YFDY FT++FTVEI LK+ FG HKG+FCRN FNLLD+LVV
Sbjct: 924 AAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVV 983
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
VSL SF +++ A+S AINRAKGLKHVVQCV VA++TIGNIM+VT
Sbjct: 984 GVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTT 1043
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG F+ C D +K ECRG +I Y+DGD PV ++R+W N+DFN
Sbjct: 1044 LLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFN 1103
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP LLY AIDSN E+ GP++N R +++
Sbjct: 1104 FDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENVGPVYNYRVEISIFFIIYIIIVAFFM 1163
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N QY+ W+ V
Sbjct: 1164 MNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVN 1223
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S+ F D +D+ N++FTGVF E VLK++A PK
Sbjct: 1224 SSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKG 1283
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGGT----------------NLISINFFRLFRV 3657
Y SD WN FD L+V+GS ID+ + +P + N ISI FFRLFRV
Sbjct: 1284 YFSDAWNTFDSLIVIGSIIDVALSEADPSESETIPLPTATPGNSEESNRISITFFRLFRV 1343
Query: 3658 MRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSI 3837
MRLVKLLSRGEGIRTLLWTF+KSFQALPYVALLI +LFFIYAVIGMQ FGKVA+ D+ I
Sbjct: 1344 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQI 1403
Query: 3838 HRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNN 4017
+RNNNF +FP A+L+LFR ATGEAWQ+IML+C + CDP SD Y+ G E CG+N
Sbjct: 1404 NRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGK--LCDPDSD-YNPG--EEYTCGSN 1458
Query: 4018 FAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKG 4197
FA YFISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+WSEYDP+AKG
Sbjct: 1459 FAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKG 1518
Query: 4198 RIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNL 4377
RIKHLDVVTLLR+I PPLGFGKLCPHR+ACKRLV+MNMPLNSDGTV FNATLFALVRT L
Sbjct: 1519 RIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTAL 1578
Query: 4378 KIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFR 4557
KI TEGN+++ANE+LR+ IK+IWK+T LLD+VVPPAG +D+VTVGKFYATFLIQDYFR
Sbjct: 1579 KIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQDYFR 1637
Query: 4558 RFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFD---EPEP 4728
+FKKRKE G PA+ +ALQAGLRTLH+IGPE++RAIS +L+ D D E E
Sbjct: 1638 KFKKRKEQGLVGKYPAKN-TTIALQAGLRTLHDIGPEIRRAISCDLQDDEPEDSKPEEED 1696
Query: 4729 QHRRPHSLFNNLVHRLSG----AGSKSPTEHERIEKGSTLLPFQPRSFSPTHSLAGAEG- 4893
+R +L N V+ ++ + ++ T H + +P + P AG G
Sbjct: 1697 VFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSMPPASDTEKPLFPPAGNSGC 1756
Query: 4894 --SPVPSQMHRGAPINQSINLPPVNGSARRLPALPPYANHIHDETDDG 5031
+ + + AP + + NL N S + PP ++ +++G
Sbjct: 1757 HNHHNHNSIGKQAPTSTNANLNNANMS-KAAHGKPPSIGNLEHVSENG 1803
Score = 717 bits (1851), Expect = 0.0
Identities = 377/686 (54%), Positives = 451/686 (64%), Gaps = 44/686 (6%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
NNPIR+ CISIVEWKPF+ IL I ANC+ALAIY P+P DS+ N LE +EY F+++
Sbjct: 112 NNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLII 171
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQ----------- 546
FT+E LKI+A G + HP+AY+RN WN+LDF+IV++GL S IL +++ +
Sbjct: 172 FTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKS 231
Query: 547 -GFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLE 723
GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+I++AM+PLLHIALLVLFVI+IYAIIGLE
Sbjct: 232 GGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLE 291
Query: 724 LFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPG 903
LF GK+H TC + +A++DP PC G+ +C + + EC S W G
Sbjct: 292 LFIGKMHKTCFFADSDIVAEEDPAPCAFS--GNGRQCTANGT--------ECRSG--WVG 339
Query: 904 PNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLN 1083
PN GITNFDNF AMLTVFQC+++EGWTDV+YWVNDA+G EWPW+YFV+L+ILGSFFVLN
Sbjct: 340 PNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLN 399
Query: 1084 LVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDE 1263
LVLGVLSGEFSKEREKA+ARG FQK REKQQLEEDLKGYLDWITQAEDI+P NE+E +E
Sbjct: 400 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEE 459
Query: 1264 -------PVAQTXXXXXXXXXXXXXXXXXXPSKW-------AAR---------------- 1353
P ++T + W AA+
Sbjct: 460 GKRNTSMPTSETESVNTENVSGEGETQGCCGTLWCWWKRRGAAKTGPSGCRRWGQAISKS 519
Query: 1354 --MKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMAN 1527
+R + N VKS TFYW +SEHY Q +WL Q +AN
Sbjct: 520 KLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIAN 579
Query: 1528 LFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLR 1707
+ LF+ EML+KMYSLG Y S FNRFDCFVV I E +LV +LM PLGVSV R
Sbjct: 580 KVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELELMSPLGVSVFR 639
Query: 1708 SARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFN 1887
RLLRIFKVT++WT GMQ+FGGKFNF+
Sbjct: 640 CVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFD 699
Query: 1888 PQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFIC 2067
Q K R+ FD F QALLTVFQILTGEDWN VMY GI ++GG + G+IVCIY+I+LFIC
Sbjct: 700 ETQTK-RSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFIC 758
Query: 2068 GNYILLNVFLAIAVDNLADADSLTNA 2145
GNYILLNVFLAIAVDNLADA+SL A
Sbjct: 759 GNYILLNVFLAIAVDNLADAESLNTA 784
Score = 128 bits (322), Expect = 1e-27
Identities = 92/312 (29%), Positives = 152/312 (48%), Gaps = 9/312 (2%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR C ++ F LIL I + ALA P + ++NT+L +Y F +F
Sbjct: 893 NPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPI--RSHSFRNTILGYFDYAFTAIF 950
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
T+E +LK+ G H A+ RN +N+LD ++V + LVS + +I VK LR RV
Sbjct: 951 TVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAIS--VVKILRVLRV 1008
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLR ++ L+ V+ + A+ + +I ++ + ++A IG++LF GK + C D
Sbjct: 1009 LRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFY-RCTDE 1067
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
A+ +P C F + + VR N+ + NFDN
Sbjct: 1068 -----AKSNPEEC-----RGLFILYKDGDVDSPVVRERIWQNSDF--------NFDNVLS 1109
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDAVG---------REWPWIYFVTLVILGSFFVLNLVLG 1095
AM+ +F + EGW ++Y D+ G R I+F+ +I+ +FF++N+ +G
Sbjct: 1110 AMMALFTVSTFEGWPALLYKAIDSNGENVGPVYNYRVEISIFFIIYIIIVAFFMMNIFVG 1169
Query: 1096 VLSGEFSKEREK 1131
+ F ++ EK
Sbjct: 1170 FVIVTFQEQGEK 1181
Score = 102 bits (255), Expect = 8e-20
Identities = 70/276 (25%), Positives = 134/276 (48%), Gaps = 1/276 (0%)
Frame = +1
Query: 3277 KAKPHRRYIPRNRL-QYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDV 3453
K+K RR+ NR + R V S F +++ +++ +NT++++ +HY D+
Sbjct: 518 KSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDI 577
Query: 3454 FNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISI 3633
N + +F E ++K+ +L + Y +N FD VV G + +L + + +
Sbjct: 578 ANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEL--MSPLGV 635
Query: 3634 NFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKV 3813
+ FR R++R+ K+ + L+ + + S +++ + LL+ L I++++GMQ FG
Sbjct: 636 SVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGK 695
Query: 3814 ALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGL 3993
D T R+ F +FP A+L +F+ TGE W +M GG
Sbjct: 696 FNFDETQTKRST-FDNFPQALLTVFQILTGEDWNAVMYD-------------GIMAYGGP 741
Query: 3994 NESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDN 4101
+ S YFI F+ +++++N+F+A+ +DN
Sbjct: 742 SSS---GMIVCIYFIILFICGNYILLNVFLAIAVDN 774
Score = 93.2 bits (230), Expect = 6e-17
Identities = 76/332 (22%), Positives = 135/332 (39%), Gaps = 35/332 (10%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP + +V PFE+++ +I N + LA+ Q Y + S N ++ + VF VF
Sbjct: 1212 NPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAM-QHY--EQSKMFNDAMDILNMVFTGVF 1268
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMS-------------- 540
T+E VLK++A F P Y +AWN D +IV+ ++ LS+
Sbjct: 1269 TVEMVLKVIA----FKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPSESETIPLPTATP 1324
Query: 541 -----IQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIY 705
+ R FRV+R ++L+S ++ +L +++ L ++ALL+ + IY
Sbjct: 1325 GNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIY 1384
Query: 706 AIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSS 885
A+IG+++F G++A +D
Sbjct: 1385 AVIGMQMF-------------GKVAMRDNNQI---------------------------- 1403
Query: 886 NTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMY----------------WVNDAV 1017
N NF F A+L +F+C + E W ++M
Sbjct: 1404 --------NRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPDSDYNPGEEYTC 1455
Query: 1018 GREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
G + +YF++ +L +F ++NL + V+ F
Sbjct: 1456 GSNFAIVYFISFYMLCAFLIINLFVAVIMDNF 1487
Score = 92.0 bits (227), Expect = 1e-16
Identities = 146/706 (20%), Positives = 255/706 (35%), Gaps = 80/706 (11%)
Frame = +1
Query: 232 RKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIE 411
R+ C + V+ F +L++ ++ N + ++ D+ + + V + +FT E
Sbjct: 533 RRRCRAAVKSVTFYWLVIVLVFLNTLTISSEH---YNQPDWLTQIQDIANKVLLALFTCE 589
Query: 412 CVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG-FDVKALRAFRVLR 588
++K+ ++G AY + +N D +V G+ TIL ++ + V R R+LR
Sbjct: 590 MLVKMYSLGLQ----AYFVSLFNRFDCFVVCGGITETILVELELMSPLGVSVFRCVRLLR 645
Query: 589 PLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPAT 768
++ SL ++ ++L +M + + LL+ I+I++++
Sbjct: 646 IFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLL------------------ 687
Query: 769 GQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAM 948
G G F + + + FDNF A+
Sbjct: 688 -----------GMQLFGGKFNFDETQTKRS---------------------TFDNFPQAL 715
Query: 949 LTVFQCVSLEGWTDVMYWVNDAVGREWP-----WIYFVTLVILGSFFVLNLVLGVLSGEF 1113
LTVFQ ++ E W VMY A G IYF+ L I G++ +LN+ L +
Sbjct: 716 LTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNL 775
Query: 1114 S---------------KEREK-ARARGLFQKFREKQQLEE----DLKGYL-DWITQAEDI 1230
+ KER+K AR L K K ++ + D K + D+ AED
Sbjct: 776 ADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYQEDAEDK 835
Query: 1231 EPV----------NEDEQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNX 1380
+P E+E+EDEP P + L K N
Sbjct: 836 DPYPPCDVPVGEEEEEEEEDEPEV-PAGPRPRRISELNMKEKIAPIPEGSAFFILSKTN- 893
Query: 1381 XXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSE-----HYGQSEWLDHFQTMANLFFVIL 1545
L+ F +E H ++ L +F + F +
Sbjct: 894 PIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYF----DYAFTAI 949
Query: 1546 FSMEMLLKMYSLGF----TTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSA 1713
F++E+LLKM + G + + FN D VV S++ F + + V +LR
Sbjct: 950 FTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISV---VKILRVL 1006
Query: 1714 RLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF----- 1878
R+LR + G+Q+F GKF
Sbjct: 1007 RVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTD 1066
Query: 1879 --NFNPQQ---------------PKPRA--------NFDTFVQALLTVFQILTGEDWNTV 1983
NP++ P R NFD + A++ +F + T E W +
Sbjct: 1067 EAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPAL 1126
Query: 1984 MYHGI----ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+Y I E+ G V V + I++I+ I + ++N+F+ +
Sbjct: 1127 LYKAIDSNGENVGPVYNYRVEISIFFIIYIIIVAFFMMNIFVGFVI 1172
Score = 88.6 bits (218), Expect = 2e-15
Identities = 79/290 (27%), Positives = 121/290 (41%), Gaps = 39/290 (13%)
Frame = +1
Query: 2323 ASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPL---QANSTRNMIL 2493
A +LF LS N R C +V F +L I + LA P +NST N L
Sbjct: 103 ARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNST-NHNL 161
Query: 2494 NYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL-----RT 2658
+Y F +FTVE LK+I +GL+ H ++ RN +NLLD ++V V L S +L T
Sbjct: 162 EKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKET 221
Query: 2659 DAMSXXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFML 2811
+ + A ++ L+ V+ +I A+ + +I L+ +
Sbjct: 222 EGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFV 281
Query: 2812 QFMFAIIGVQLF-----KGTFFLCNDLSKMTE-----------------AECRGEYIHYE 2925
++AIIG++LF K FF +D+ + ECR ++
Sbjct: 282 IIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPN 341
Query: 2926 DGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
G NFDN AM+++F T EGW +LY D+
Sbjct: 342 GGIT---------------NFDNFAFAMLTVFQCITMEGWTDVLYWVNDA 376
Score = 83.2 bits (204), Expect = 7e-14
Identities = 81/352 (23%), Positives = 140/352 (39%), Gaps = 53/352 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ F+ I L I N V+LA +P S L+ F +F E LKI+A
Sbjct: 126 KPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGL 185
Query: 3511 -LNPKNYISDRWNVFDLLVVVGSFIDITYGKL---------NPGGTNLISINFFRLFRVM 3660
L+P Y+ + WN+ D ++V+ + +L + G + + R FRV+
Sbjct: 186 LLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVL 245
Query: 3661 RLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF------------ 3804
R ++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F
Sbjct: 246 RPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFAD 305
Query: 3805 -----------------GKVALDDSTSIHRN--------NNFHSFPAAILVLFRSATGEA 3909
G+ + T NF +F A+L +F+ T E
Sbjct: 306 SDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEG 365
Query: 3910 WQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAV 4089
W D++ +D G + + YF+S +L SF V+NL + V
Sbjct: 366 WTDVLYWVND---------------------AIGWEWPWVYFVSLIILGSFFVLNLVLGV 404
Query: 4090 IMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
+ F G + +R + + D KG +LD +T I P
Sbjct: 405 LSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 450
Score = 68.6 bits (166), Expect = 2e-09
Identities = 53/245 (21%), Positives = 98/245 (39%), Gaps = 32/245 (13%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HY QS+ + + N+ F +F++EM+LK+ + Y + +N FD +VI SI++
Sbjct: 1245 QHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDV 1304
Query: 1657 VLVYFDLMKP------------------LGVSVLRSARLLRIFKVTKYWTXXXXXXXXXX 1782
L D + + ++ R R++R+ K+
Sbjct: 1305 ALSEADPSESETIPLPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFI 1364
Query: 1783 XXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILT 1962
GMQ+FG + Q NF TF QA+L +F+ T
Sbjct: 1365 KSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCAT 1424
Query: 1963 GEDWNTVM--------------YHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLA 2100
GE W +M Y+ E + + +Y+I ++ ++++N+F+A
Sbjct: 1425 GEAWQEIMLACLPGKLCDPDSDYNPGEEYTCGSNFAI---VYFISFYMLCAFLIINLFVA 1481
Query: 2101 IAVDN 2115
+ +DN
Sbjct: 1482 VIMDN 1486
>gi|4502527|ref|NP_000711.1| calcium channel, voltage-dependent, L
type, alpha 1D subunit [Homo sapiens]
gi|482305|pir||A38198 calcium channel alpha-1 chain, pancreatic -
human
gi|179752|gb|AAA35629.1| calcium channel alpha-1 subunit
Length = 2181
Score = 1050 bits (2714), Expect = 0.0
Identities = 526/840 (62%), Positives = 640/840 (75%), Gaps = 16/840 (1%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPRR+SE+ + PIP+ S+ FILS TN RV C+ ++NH FTN +L I++SSA L
Sbjct: 864 RPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAAL 923
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP++++S RN IL YFDY FT++FTVEI LK+ FG HKG+FCRN FNLLD+LVV
Sbjct: 924 AAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVV 983
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
VSL SF +++ A+S AINRAKGLKHVVQCV VA++TIGNIM+VT
Sbjct: 984 GVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTT 1043
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG F+ C D +K ECRG +I Y+DGD PV ++R+W N+DFN
Sbjct: 1044 LLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFN 1103
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP LLY AIDSN E+ GPI+N R +++
Sbjct: 1104 FDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFM 1163
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N QY+ W+ V
Sbjct: 1164 MNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVN 1223
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S+ F D +D+ N++FTGVF E VLK++A PK
Sbjct: 1224 SSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKG 1283
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGGT----------------NLISINFFRLFRV 3657
Y SD WN FD L+V+GS ID+ + +P + N ISI FFRLFRV
Sbjct: 1284 YFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFRLFRV 1343
Query: 3658 MRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSI 3837
MRLVKLLSRGEGIRTLLWTF+KSFQALPYVALLI +LFFIYAVIGMQ FGKVA+ D+ I
Sbjct: 1344 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQI 1403
Query: 3838 HRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNN 4017
+RNNNF +FP A+L+LFR ATGEAWQ+IML+C + CDP SD Y+ G E CG+N
Sbjct: 1404 NRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGK--LCDPESD-YNPG--EEYTCGSN 1458
Query: 4018 FAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKG 4197
FA YFISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+WSEYDP+AKG
Sbjct: 1459 FAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKG 1518
Query: 4198 RIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNL 4377
RIKHLDVVTLLR+I PPLGFGKLCPHR+ACKRLV+MNMPLNSDGTV FNATLFALVRT L
Sbjct: 1519 RIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTAL 1578
Query: 4378 KIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFR 4557
KI TEGN+++ANE+LR+ IK+IWK+T LLD+VVPPAG +D+VTVGKFYATFLIQDYFR
Sbjct: 1579 KIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQDYFR 1637
Query: 4558 RFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDEPEPQHR 4737
+FKKRKE G PA+ +ALQAGLRTLH+IGPE++RAIS +L+ DEPE R
Sbjct: 1638 KFKKRKEQGLVGKYPAKN-TTIALQAGLRTLHDIGPEIRRAISCDLQD----DEPEETKR 1692
Score = 717 bits (1850), Expect = 0.0
Identities = 376/686 (54%), Positives = 451/686 (64%), Gaps = 44/686 (6%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
NNPIR+ CISIVEWKPF+ IL I ANC+ALAIY P+P DS+ N LE +EY F+++
Sbjct: 112 NNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLII 171
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQ----------- 546
FT+E LKI+A G + HP+AY+RN WN+LDF+IV++GL S IL +++ +
Sbjct: 172 FTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKS 231
Query: 547 -GFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLE 723
GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+I++AM+PLLHIALLVLFVI+IYAIIGLE
Sbjct: 232 GGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLE 291
Query: 724 LFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPG 903
LF GK+H TC + +A++DP PC G+ +C + + EC S W G
Sbjct: 292 LFIGKMHKTCFFADSDIVAEEDPAPCAFS--GNGRQCTANGT--------ECRSG--WVG 339
Query: 904 PNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLN 1083
PN GITNFDNF AMLTVFQC+++EGWTDV+YWVNDA+G EWPW+YFV+L+ILGSFFVLN
Sbjct: 340 PNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLN 399
Query: 1084 LVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDE 1263
LVLGVLSGEFSKEREKA+ARG FQK REKQQLEEDLKGYLDWITQAEDI+P NE+E +E
Sbjct: 400 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEE 459
Query: 1264 -------PVAQTXXXXXXXXXXXXXXXXXXPSKW-------AAR---------------- 1353
P ++T S W AA+
Sbjct: 460 GKRNTSMPTSETESVNTENVSGEGENRGCCGSLWCWWRRRGAAKAGPSGCRRWGQAISKS 519
Query: 1354 --MKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMAN 1527
+R + N VKS TFYW +SEHY Q +WL Q +AN
Sbjct: 520 KLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIAN 579
Query: 1528 LFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLR 1707
+ LF+ EML+KMYSLG Y S FNRFDCFVV I E +LV ++M PLG+SV R
Sbjct: 580 KVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFR 639
Query: 1708 SARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFN 1887
RLLRIFKVT++WT GMQ+FGGKFNF+
Sbjct: 640 CVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFD 699
Query: 1888 PQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFIC 2067
Q K R+ FD F QALLTVFQILTGEDWN VMY GI ++GG + G+IVCIY+I+LFIC
Sbjct: 700 ETQTK-RSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFIC 758
Query: 2068 GNYILLNVFLAIAVDNLADADSLTNA 2145
GNYILLNVFLAIAVDNLADA+SL A
Sbjct: 759 GNYILLNVFLAIAVDNLADAESLNTA 784
Score = 129 bits (323), Expect = 1e-27
Identities = 92/312 (29%), Positives = 151/312 (47%), Gaps = 9/312 (2%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR C ++ F LIL I + ALA P + ++NT+L +Y F +F
Sbjct: 893 NPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPI--RSHSFRNTILGYFDYAFTAIF 950
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
T+E +LK+ G H A+ RN +N+LD ++V + LVS + +I VK LR RV
Sbjct: 951 TVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAIS--VVKILRVLRV 1008
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLR ++ L+ V+ + A+ + +I ++ + ++A IG++LF GK + C D
Sbjct: 1009 LRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFY-RCTDE 1067
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
A+ +P C F + + VR N+ + NFDN
Sbjct: 1068 -----AKSNPEEC-----RGLFILYKDGDVDSPVVRERIWQNSDF--------NFDNVLS 1109
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIY---------FVTLVILGSFFVLNLVLG 1095
AM+ +F + EGW ++Y D+ G IY F+ +I+ +FF++N+ +G
Sbjct: 1110 AMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVG 1169
Query: 1096 VLSGEFSKEREK 1131
+ F ++ EK
Sbjct: 1170 FVIVTFQEQGEK 1181
Score = 103 bits (256), Expect = 6e-20
Identities = 71/276 (25%), Positives = 134/276 (47%), Gaps = 1/276 (0%)
Frame = +1
Query: 3277 KAKPHRRYIPRNRL-QYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDV 3453
K+K RR+ NR + R V S F +++ +++ +NT++++ +HY D+
Sbjct: 518 KSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDI 577
Query: 3454 FNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISI 3633
N + +F E ++K+ +L + Y +N FD VV G + +L + + I
Sbjct: 578 ANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEI--MSPLGI 635
Query: 3634 NFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKV 3813
+ FR R++R+ K+ + L+ + + S +++ + LL+ L I++++GMQ FG
Sbjct: 636 SVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGK 695
Query: 3814 ALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGL 3993
D T R+ F +FP A+L +F+ TGE W +M GG
Sbjct: 696 FNFDETQTKRST-FDNFPQALLTVFQILTGEDWNAVMYD-------------GIMAYGGP 741
Query: 3994 NESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDN 4101
+ S YFI F+ +++++N+F+A+ +DN
Sbjct: 742 SSS---GMIVCIYFIILFICGNYILLNVFLAIAVDN 774
Score = 93.2 bits (230), Expect = 6e-17
Identities = 76/332 (22%), Positives = 135/332 (39%), Gaps = 35/332 (10%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP + +V PFE+++ +I N + LA+ Q Y + S N ++ + VF VF
Sbjct: 1212 NPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAM-QHY--EQSKMFNDAMDILNMVFTGVF 1268
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMS-------------- 540
T+E VLK++A F P Y +AWN D +IV+ ++ LS+
Sbjct: 1269 TVEMVLKVIA----FKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATP 1324
Query: 541 -----IQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIY 705
+ R FRV+R ++L+S ++ +L +++ L ++ALL+ + IY
Sbjct: 1325 GNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIY 1384
Query: 706 AIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSS 885
A+IG+++F G++A +D
Sbjct: 1385 AVIGMQMF-------------GKVAMRDNNQI---------------------------- 1403
Query: 886 NTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMY----------------WVNDAV 1017
N NF F A+L +F+C + E W ++M
Sbjct: 1404 --------NRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTC 1455
Query: 1018 GREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
G + +YF++ +L +F ++NL + V+ F
Sbjct: 1456 GSNFAIVYFISFYMLCAFLIINLFVAVIMDNF 1487
Score = 90.5 bits (223), Expect = 4e-16
Identities = 145/706 (20%), Positives = 257/706 (35%), Gaps = 80/706 (11%)
Frame = +1
Query: 232 RKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIE 411
R+ C + V+ F +L++ ++ N + ++ D+ + + V + +FT E
Sbjct: 533 RRRCRAAVKSVTFYWLVIVLVFLNTLTISSEH---YNQPDWLTQIQDIANKVLLALFTCE 589
Query: 412 CVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG-FDVKALRAFRVLR 588
++K+ ++G AY + +N D +V G+ TIL ++ I + R R+LR
Sbjct: 590 MLVKMYSLGLQ----AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLR 645
Query: 589 PLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPAT 768
++ SL ++ ++L +M + + LL+ I+I++++
Sbjct: 646 IFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLL------------------ 687
Query: 769 GQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAM 948
G G F + + + FDNF A+
Sbjct: 688 -----------GMQLFGGKFNFDETQTKRS---------------------TFDNFPQAL 715
Query: 949 LTVFQCVSLEGWTDVMYWVNDAVGREWP-----WIYFVTLVILGSFFVLNLVLGVLSGEF 1113
LTVFQ ++ E W VMY A G IYF+ L I G++ +LN+ L +
Sbjct: 716 LTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNL 775
Query: 1114 S---------------KEREK-ARARGLFQKFREKQQLEE----DLKGYL-DWITQAEDI 1230
+ KER+K AR L K K ++ + D K + D+ + ED
Sbjct: 776 ADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDK 835
Query: 1231 EPV----------NEDEQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNX 1380
+P E+E+EDEP P + L K N
Sbjct: 836 DPYPPCDVPVGEEEEEEEEDEPEV-PAGPRPRRISELNMKEKIAPIPEGSAFFILSKTN- 893
Query: 1381 XXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSE-----HYGQSEWLDHFQTMANLFFVIL 1545
L+ F +E H ++ L +F + F +
Sbjct: 894 PIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYF----DYAFTAI 949
Query: 1546 FSMEMLLKMYSLGF----TTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSA 1713
F++E+LLKM + G + + FN D VV S++ F + + V +LR
Sbjct: 950 FTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISV---VKILRVL 1006
Query: 1714 RLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF----- 1878
R+LR + G+Q+F GKF
Sbjct: 1007 RVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTD 1066
Query: 1879 --NFNPQQ---------------PKPRA--------NFDTFVQALLTVFQILTGEDWNTV 1983
NP++ P R NFD + A++ +F + T E W +
Sbjct: 1067 EAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPAL 1126
Query: 1984 MYHGIESFG-GVGTL---GVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+Y I+S G +G + V + I++I+ I + ++N+F+ +
Sbjct: 1127 LYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVI 1172
Score = 88.6 bits (218), Expect = 2e-15
Identities = 79/290 (27%), Positives = 121/290 (41%), Gaps = 39/290 (13%)
Frame = +1
Query: 2323 ASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPL---QANSTRNMIL 2493
A +LF LS N R C +V F +L I + LA P +NST N L
Sbjct: 103 ARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNST-NHNL 161
Query: 2494 NYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL-----RT 2658
+Y F +FTVE LK+I +GL+ H ++ RN +NLLD ++V V L S +L T
Sbjct: 162 EKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKET 221
Query: 2659 DAMSXXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFML 2811
+ + A ++ L+ V+ +I A+ + +I L+ +
Sbjct: 222 EGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFV 281
Query: 2812 QFMFAIIGVQLF-----KGTFFLCNDLSKMTE-----------------AECRGEYIHYE 2925
++AIIG++LF K FF +D+ + ECR ++
Sbjct: 282 IIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPN 341
Query: 2926 DGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
G NFDN AM+++F T EGW +LY D+
Sbjct: 342 GGIT---------------NFDNFAFAMLTVFQCITMEGWTDVLYWVNDA 376
Score = 83.2 bits (204), Expect = 7e-14
Identities = 81/352 (23%), Positives = 140/352 (39%), Gaps = 53/352 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ F+ I L I N V+LA +P S L+ F +F E LKI+A
Sbjct: 126 KPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGL 185
Query: 3511 -LNPKNYISDRWNVFDLLVVVGSFIDITYGKL---------NPGGTNLISINFFRLFRVM 3660
L+P Y+ + WN+ D ++V+ + +L + G + + R FRV+
Sbjct: 186 LLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVL 245
Query: 3661 RLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF------------ 3804
R ++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F
Sbjct: 246 RPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFAD 305
Query: 3805 -----------------GKVALDDSTSIHRN--------NNFHSFPAAILVLFRSATGEA 3909
G+ + T NF +F A+L +F+ T E
Sbjct: 306 SDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEG 365
Query: 3910 WQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAV 4089
W D++ +D G + + YF+S +L SF V+NL + V
Sbjct: 366 WTDVLYWVND---------------------AIGWEWPWVYFVSLIILGSFFVLNLVLGV 404
Query: 4090 IMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
+ F G + +R + + D KG +LD +T I P
Sbjct: 405 LSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 450
Score = 68.6 bits (166), Expect = 2e-09
Identities = 56/242 (23%), Positives = 99/242 (40%), Gaps = 29/242 (11%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HY QS+ + + N+ F +F++EM+LK+ + Y + +N FD +VI SI++
Sbjct: 1245 QHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDV 1304
Query: 1657 VLVYFDLMKP------------------LGVSVLRSARLLRIFKVTKYWTXXXXXXXXXX 1782
L D + + ++ R R++R+ K+
Sbjct: 1305 ALSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFI 1364
Query: 1783 XXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILT 1962
GMQ+FG + Q NF TF QA+L +F+ T
Sbjct: 1365 KSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCAT 1424
Query: 1963 GEDWNTVMYHGI-------ESFGGVG---TLGV-IVCIYYIVLFICGNYILLNVFLAIAV 2109
GE W +M + ES G T G +Y+I ++ ++++N+F+A+ +
Sbjct: 1425 GEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIM 1484
Query: 2110 DN 2115
DN
Sbjct: 1485 DN 1486
>gi|1304105|dbj|BAA07804.1| voltage-dependent calcium channel alpha1
subunit, CACN4 [Homo sapiens]
Length = 2170
Score = 1049 bits (2712), Expect = 0.0
Identities = 527/838 (62%), Positives = 639/838 (75%), Gaps = 14/838 (1%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPRR+SE+ + PIP+ S+ FILS TN RV C+ ++NH FTN +L I++SSA L
Sbjct: 855 RPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAAL 914
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP++++S RN L YFDY FT++FTVEI LK+ FG HKG+FCRN FNLLDILVV
Sbjct: 915 AAEDPIRSHSFRNTTLGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDILVV 974
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
VSL SF +++ A+S AINRAKGLKHVVQCV VA++TIGNIM+VT
Sbjct: 975 GVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTT 1034
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG F+ C D +K ECRG +I Y+DGD PV ++R+W N+DFN
Sbjct: 1035 LLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFN 1094
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP LLY AIDSN E+ GPI+N R +++
Sbjct: 1095 FDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFM 1154
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N QY+ W+ V
Sbjct: 1155 MNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVN 1214
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S+ F D +D+ N++FTGVF E VLK++A PK
Sbjct: 1215 SSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKG 1274
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGK-----------LNPGGT---NLISINFFRLFRVMR 3663
Y SD WN FD L+V+GS ID+ + PG + N ISI FFRLFRVMR
Sbjct: 1275 YFSDAWNTFDSLIVIGSIIDVALSEPTESENVPVPTATPGNSEESNRISITFFRLFRVMR 1334
Query: 3664 LVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHR 3843
LVKLLSRGEGIRTLLWTF+KSFQALPYVALLI +LFFIYAVIGMQ FGKVA+ D+ I+R
Sbjct: 1335 LVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINR 1394
Query: 3844 NNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFA 4023
NNNF +FP A+L+LFR ATGEAWQ+IML+C + CDP SD Y+ G E CG+NFA
Sbjct: 1395 NNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGK--LCDPESD-YNPG--EEYTCGSNFA 1449
Query: 4024 YPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRI 4203
YFISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+WSEYDP+AKGRI
Sbjct: 1450 IVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRI 1509
Query: 4204 KHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKI 4383
KHLDVVTLLR+I PPLGFGKLCPHR+ACKRLV+MNMPLNSDGTV FNATLFALVRT LKI
Sbjct: 1510 KHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKI 1569
Query: 4384 YTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRF 4563
TEGN+++ANE+LR+ IK+IWK+T LLD+VVPPAG +D+VTVGKFYATFLIQDYFR+F
Sbjct: 1570 KTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQDYFRKF 1628
Query: 4564 KKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDEPEPQHR 4737
KKRKE G PA+ +ALQAGLRTLH+IGPE++RAIS +L+ DEPE R
Sbjct: 1629 KKRKEQGLVGKYPAKN-TTIALQAGLRTLHDIGPEIRRAISCDLQD----DEPEETKR 1681
Score = 716 bits (1847), Expect = 0.0
Identities = 375/686 (54%), Positives = 451/686 (65%), Gaps = 44/686 (6%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
NNPIR+ CISIVEWKPF+ IL I ANC+ALAIY P+P DS+ N LE +EY F+++
Sbjct: 103 NNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLII 162
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQ----------- 546
FT+E LKI+A G + HP+AY+RN WN+LDF+IV++GL S IL +++ +
Sbjct: 163 FTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKS 222
Query: 547 -GFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLE 723
GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+I++AM+PLLHIALLVLFVI+IYAIIGLE
Sbjct: 223 GGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLE 282
Query: 724 LFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPG 903
LF GK+H TC + +A++DP PC G+ +C + + EC S W G
Sbjct: 283 LFIGKMHKTCFFADSDIVAEEDPAPCAFS--GNGRQCTANGT--------ECRSG--WVG 330
Query: 904 PNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLN 1083
PN GITNFDNF AMLTVFQC+++EGWTDV+YWVNDA+G EWPW+YFV+L+ILGSFFVLN
Sbjct: 331 PNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLN 390
Query: 1084 LVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDE 1263
LVLGVLSGEFSKEREKA+ARG FQK REKQQLEEDLKGYLDWITQAEDI+P NE+E +E
Sbjct: 391 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEE 450
Query: 1264 -------PVAQTXXXXXXXXXXXXXXXXXXPSKW-------AAR---------------- 1353
P ++T S W AA+
Sbjct: 451 GKRNTSMPTSETESVNTENVSGEGENRGCCGSLWCWWRRRGAAKAGPSGCRRWGQAISKS 510
Query: 1354 --MKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMAN 1527
+R + N VKS TFYW +SEHY Q +WL Q +AN
Sbjct: 511 KLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIAN 570
Query: 1528 LFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLR 1707
+ LF+ EML+KMY+LG Y S FNRFDCFVV I E +LV ++M PLG+SV R
Sbjct: 571 KVLLALFTCEMLVKMYTLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFR 630
Query: 1708 SARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFN 1887
RLLRIFKVT++WT GMQ+FGGKFNF+
Sbjct: 631 CVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFD 690
Query: 1888 PQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFIC 2067
Q K R+ FD F QALLTVFQILTGEDWN VMY GI ++GG + G+IVCIY+I+LFIC
Sbjct: 691 ETQTK-RSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFIC 749
Query: 2068 GNYILLNVFLAIAVDNLADADSLTNA 2145
GNYILLNVFLAIAVDNLADA+SL A
Sbjct: 750 GNYILLNVFLAIAVDNLADAESLNTA 775
Score = 127 bits (320), Expect = 2e-27
Identities = 92/312 (29%), Positives = 150/312 (47%), Gaps = 9/312 (2%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR C ++ F LIL I + ALA P + ++NT L +Y F +F
Sbjct: 884 NPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPI--RSHSFRNTTLGYFDYAFTAIF 941
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
T+E +LK+ G H A+ RN +N+LD ++V + LVS + +I VK LR RV
Sbjct: 942 TVEILLKMTTFGAFLHKGAFCRNYFNLLDILVVGVSLVSFGIQSSAIS--VVKILRVLRV 999
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLR ++ L+ V+ + A+ + +I ++ + ++A IG++LF GK + C D
Sbjct: 1000 LRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFY-RCTDE 1058
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
A+ +P C F + + VR N+ + NFDN
Sbjct: 1059 -----AKSNPEEC-----RGLFILYKDGDVDSPVVRERIWQNSDF--------NFDNVLS 1100
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIY---------FVTLVILGSFFVLNLVLG 1095
AM+ +F + EGW ++Y D+ G IY F+ +I+ +FF++N+ +G
Sbjct: 1101 AMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVG 1160
Query: 1096 VLSGEFSKEREK 1131
+ F ++ EK
Sbjct: 1161 FVIVTFQEQGEK 1172
Score = 102 bits (255), Expect = 8e-20
Identities = 71/276 (25%), Positives = 133/276 (47%), Gaps = 1/276 (0%)
Frame = +1
Query: 3277 KAKPHRRYIPRNRL-QYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDV 3453
K+K RR+ NR + R V S F +++ +++ +NT++++ +HY D+
Sbjct: 509 KSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDI 568
Query: 3454 FNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISI 3633
N + +F E ++K+ L + Y +N FD VV G + +L + + I
Sbjct: 569 ANKVLLALFTCEMLVKMYTLGLQAYFVSLFNRFDCFVVCGGITETILVELEI--MSPLGI 626
Query: 3634 NFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKV 3813
+ FR R++R+ K+ + L+ + + S +++ + LL+ L I++++GMQ FG
Sbjct: 627 SVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGK 686
Query: 3814 ALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGL 3993
D T R+ F +FP A+L +F+ TGE W +M GG
Sbjct: 687 FNFDETQTKRST-FDNFPQALLTVFQILTGEDWNAVMYD-------------GIMAYGGP 732
Query: 3994 NESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDN 4101
+ S YFI F+ +++++N+F+A+ +DN
Sbjct: 733 SSS---GMIVCIYFIILFICGNYILLNVFLAIAVDN 765
Score = 94.0 bits (232), Expect = 4e-17
Identities = 76/330 (23%), Positives = 136/330 (41%), Gaps = 33/330 (10%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP + +V PFE+++ +I N + LA+ Q Y + S N ++ + VF VF
Sbjct: 1203 NPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAM-QHY--EQSKMFNDAMDILNMVFTGVF 1259
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMS-------------- 540
T+E VLK++A F P Y +AWN D +IV+ ++ LS+ +
Sbjct: 1260 TVEMVLKVIA----FKPKGYFSDAWNTFDSLIVIGSIIDVALSEPTESENVPVPTATPGN 1315
Query: 541 ---IQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAI 711
+ R FRV+R ++L+S ++ +L +++ L ++ALL+ + IYA+
Sbjct: 1316 SEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAV 1375
Query: 712 IGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNT 891
IG+++F G++A +D
Sbjct: 1376 IGMQMF-------------GKVAMRDNNQI------------------------------ 1392
Query: 892 TWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMY----------------WVNDAVGR 1023
N NF F A+L +F+C + E W ++M G
Sbjct: 1393 ------NRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGS 1446
Query: 1024 EWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
+ +YF++ +L +F ++NL + V+ F
Sbjct: 1447 NFAIVYFISFYMLCAFLIINLFVAVIMDNF 1476
Score = 90.5 bits (223), Expect = 4e-16
Identities = 145/706 (20%), Positives = 256/706 (35%), Gaps = 80/706 (11%)
Frame = +1
Query: 232 RKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIE 411
R+ C + V+ F +L++ ++ N + ++ D+ + + V + +FT E
Sbjct: 524 RRRCRAAVKSVTFYWLVIVLVFLNTLTISSEH---YNQPDWLTQIQDIANKVLLALFTCE 580
Query: 412 CVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG-FDVKALRAFRVLR 588
++K+ +G AY + +N D +V G+ TIL ++ I + R R+LR
Sbjct: 581 MLVKMYTLGLQ----AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLR 636
Query: 589 PLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPAT 768
++ SL ++ ++L +M + + LL+ I+I++++
Sbjct: 637 IFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLL------------------ 678
Query: 769 GQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAM 948
G G F + + + FDNF A+
Sbjct: 679 -----------GMQLFGGKFNFDETQTKRS---------------------TFDNFPQAL 706
Query: 949 LTVFQCVSLEGWTDVMYWVNDAVGREWP-----WIYFVTLVILGSFFVLNLVLGVLSGEF 1113
LTVFQ ++ E W VMY A G IYF+ L I G++ +LN+ L +
Sbjct: 707 LTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNL 766
Query: 1114 S---------------KEREK-ARARGLFQKFREKQQLEE----DLKGYL-DWITQAEDI 1230
+ KER+K AR L K K ++ + D K + D+ + ED
Sbjct: 767 ADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDK 826
Query: 1231 EPV----------NEDEQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNX 1380
+P E+E+EDEP P + L K N
Sbjct: 827 DPYPPCDVPVGEEEEEEEEDEPEV-PAGPRPRRISELNMKEKIAPIPEGSAFFILSKTN- 884
Query: 1381 XXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSE-----HYGQSEWLDHFQTMANLFFVIL 1545
L+ F +E H ++ L +F + F +
Sbjct: 885 PIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTTLGYF----DYAFTAI 940
Query: 1546 FSMEMLLKMYSLGF----TTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSA 1713
F++E+LLKM + G + + FN D VV S++ F + + V +LR
Sbjct: 941 FTVEILLKMTTFGAFLHKGAFCRNYFNLLDILVVGVSLVSFGIQSSAISV---VKILRVL 997
Query: 1714 RLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF----- 1878
R+LR + G+Q+F GKF
Sbjct: 998 RVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTD 1057
Query: 1879 --NFNPQQ---------------PKPRA--------NFDTFVQALLTVFQILTGEDWNTV 1983
NP++ P R NFD + A++ +F + T E W +
Sbjct: 1058 EAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPAL 1117
Query: 1984 MYHGIESFG-GVGTL---GVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+Y I+S G +G + V + I++I+ I + ++N+F+ +
Sbjct: 1118 LYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVI 1163
Score = 88.6 bits (218), Expect = 2e-15
Identities = 79/290 (27%), Positives = 121/290 (41%), Gaps = 39/290 (13%)
Frame = +1
Query: 2323 ASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPL---QANSTRNMIL 2493
A +LF LS N R C +V F +L I + LA P +NST N L
Sbjct: 94 ARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNST-NHNL 152
Query: 2494 NYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL-----RT 2658
+Y F +FTVE LK+I +GL+ H ++ RN +NLLD ++V V L S +L T
Sbjct: 153 EKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKET 212
Query: 2659 DAMSXXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFML 2811
+ + A ++ L+ V+ +I A+ + +I L+ +
Sbjct: 213 EGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFV 272
Query: 2812 QFMFAIIGVQLF-----KGTFFLCNDLSKMTE-----------------AECRGEYIHYE 2925
++AIIG++LF K FF +D+ + ECR ++
Sbjct: 273 IIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPN 332
Query: 2926 DGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
G NFDN AM+++F T EGW +LY D+
Sbjct: 333 GGIT---------------NFDNFAFAMLTVFQCITMEGWTDVLYWVNDA 367
Score = 83.2 bits (204), Expect = 7e-14
Identities = 81/352 (23%), Positives = 140/352 (39%), Gaps = 53/352 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ F+ I L I N V+LA +P S L+ F +F E LKI+A
Sbjct: 117 KPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGL 176
Query: 3511 -LNPKNYISDRWNVFDLLVVVGSFIDITYGKL---------NPGGTNLISINFFRLFRVM 3660
L+P Y+ + WN+ D ++V+ + +L + G + + R FRV+
Sbjct: 177 LLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVL 236
Query: 3661 RLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF------------ 3804
R ++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F
Sbjct: 237 RPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFAD 296
Query: 3805 -----------------GKVALDDSTSIHRN--------NNFHSFPAAILVLFRSATGEA 3909
G+ + T NF +F A+L +F+ T E
Sbjct: 297 SDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEG 356
Query: 3910 WQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAV 4089
W D++ +D G + + YF+S +L SF V+NL + V
Sbjct: 357 WTDVLYWVND---------------------AIGWEWPWVYFVSLIILGSFFVLNLVLGV 395
Query: 4090 IMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
+ F G + +R + + D KG +LD +T I P
Sbjct: 396 LSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 441
Score = 67.8 bits (164), Expect = 3e-09
Identities = 57/240 (23%), Positives = 99/240 (40%), Gaps = 27/240 (11%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HY QS+ + + N+ F +F++EM+LK+ + Y + +N FD +VI SI++
Sbjct: 1236 QHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDV 1295
Query: 1657 VL--------VYFDLMKP--------LGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXX 1788
L V P + ++ R R++R+ K+
Sbjct: 1296 ALSEPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKS 1355
Query: 1789 XXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGE 1968
GMQ+FG + Q NF TF QA+L +F+ TGE
Sbjct: 1356 FQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGE 1415
Query: 1969 DWNTVMYHGI-------ESFGGVG---TLGV-IVCIYYIVLFICGNYILLNVFLAIAVDN 2115
W +M + ES G T G +Y+I ++ ++++N+F+A+ +DN
Sbjct: 1416 AWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDN 1475
>gi|6165985|sp|Q01668|CCAD_HUMAN Voltage-dependent L-type calcium
channel alpha-1D subunit (Voltage-gated calcium channel
alpha subunit Cav1.3) (Calcium channel, L type, alpha-1
polypeptide, isoform 2)
gi|179764|gb|AAA58402.1| calcium channel alpha-1D subunit
Length = 2161
Score = 1048 bits (2709), Expect = 0.0
Identities = 525/840 (62%), Positives = 639/840 (75%), Gaps = 16/840 (1%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPRR+SE+ + PIP+ S+ FILS TN RV C+ ++NH FTN +L I++SSA L
Sbjct: 844 RPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAAL 903
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP++++S RN IL YFDY FT++FTVEI LK+ FG HKG+FCRN FNLLD+LVV
Sbjct: 904 AAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVV 963
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
VSL SF +++ A+S AINRAKGLKHVVQCV VA++TIGNIM+VT
Sbjct: 964 GVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTT 1023
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG F+ C D +K ECRG +I Y+DGD PV ++R+W N+DFN
Sbjct: 1024 LLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFN 1083
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP LLY AIDSN E+ GPI+N R +++
Sbjct: 1084 FDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFM 1143
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N QY+ W+ V
Sbjct: 1144 MNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVN 1203
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S+ F D +D+ N++FTGVF E VLK++A PK
Sbjct: 1204 SSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKG 1263
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGGT----------------NLISINFFRLFRV 3657
Y SD WN FD L+V+GS ID+ + +P + N ISI FFRLFRV
Sbjct: 1264 YFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFRLFRV 1323
Query: 3658 MRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSI 3837
MRLVKLLSRGEGIRTLLWTF+K FQALPYVALLI +LFFIYAVIGMQ FGKVA+ D+ I
Sbjct: 1324 MRLVKLLSRGEGIRTLLWTFIKFFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQI 1383
Query: 3838 HRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNN 4017
+RNNNF +FP A+L+LFR ATGEAWQ+IML+C + CDP SD Y+ G E CG+N
Sbjct: 1384 NRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGK--LCDPESD-YNPG--EEHTCGSN 1438
Query: 4018 FAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKG 4197
FA YFISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+WSEYDP+AKG
Sbjct: 1439 FAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKG 1498
Query: 4198 RIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNL 4377
RIKHLDVVTLLR+I PPLGFGKLCPHR+ACKRLV+MNMPLNSDGTV FNATLFALVRT L
Sbjct: 1499 RIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTAL 1558
Query: 4378 KIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFR 4557
KI TEGN+++ANE+LR+ IK+IWK+T LLD+VVPPAG +D+VTVGKFYATFLIQDYFR
Sbjct: 1559 KIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQDYFR 1617
Query: 4558 RFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDEPEPQHR 4737
+FKKRKE G PA+ +ALQAGLRTLH+IGPE++RAIS +L+ DEPE R
Sbjct: 1618 KFKKRKEQGLVGKYPAKN-TTIALQAGLRTLHDIGPEIRRAISCDLQD----DEPEETKR 1672
Score = 714 bits (1842), Expect = 0.0
Identities = 373/669 (55%), Positives = 448/669 (66%), Gaps = 27/669 (4%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
NNPIR+ CISIVEWKPF+ IL I ANC+ALAIY P+P DS+ N LE +EY F+++
Sbjct: 112 NNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLII 171
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQ----------- 546
FT+E LKI+A G + HP+AY+RN WN+LDF+IV++GL S IL +++ +
Sbjct: 172 FTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKS 231
Query: 547 -GFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLE 723
GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+I++AM+PLLHIALLVLFVI+IYAIIGLE
Sbjct: 232 GGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLE 291
Query: 724 LFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPG 903
LF GK+H TC + +A++DP PC G+ +C + + EC S W G
Sbjct: 292 LFIGKMHKTCFFADSDIVAEEDPAPCAFS--GNGRQCTANGT--------ECRSG--WVG 339
Query: 904 PNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLN 1083
PN GITNFDNF AMLTVFQC+++EGWTDV+YW+NDA+G E PW+YFV+LVI GSFFVLN
Sbjct: 340 PNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLN 399
Query: 1084 LVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDE 1263
LVLGVLSGEFSKEREKA+ARG FQK REKQQLEEDLKGYLDWITQAEDI+P NE+E +E
Sbjct: 400 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEE 459
Query: 1264 -------PVAQTXXXXXXXXXX--------XXXXXXXXPSKWAARMKRLEKLNXXXXXXX 1398
P ++T SK + R +R + N
Sbjct: 460 GKRNTSMPTSETESVNTENVSGEGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAA 519
Query: 1399 XXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYS 1578
VKS TFYW +SEHY Q +WL Q +AN + LF+ EML+KMYS
Sbjct: 520 ---VKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYS 576
Query: 1579 LGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXX 1758
LG Y S FNRFDCFVV I E +LV ++M PLG+SV R RLLRIFKVT++WT
Sbjct: 577 LGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSL 636
Query: 1759 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQAL 1938
GMQ+FGGKFNF+ Q K R+ FD F QAL
Sbjct: 637 CNLVASLLNSMKSSASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTK-RSTFDNFPQAL 695
Query: 1939 LTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNL 2118
LTVFQILTGEDWN VMY GI ++GG + G+IVCIY+I+LFICGNYILLNVFLAIAVDNL
Sbjct: 696 LTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNL 755
Query: 2119 ADADSLTNA 2145
ADA+SL A
Sbjct: 756 ADAESLNTA 764
Score = 129 bits (323), Expect = 1e-27
Identities = 92/312 (29%), Positives = 151/312 (47%), Gaps = 9/312 (2%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR C ++ F LIL I + ALA P + ++NT+L +Y F +F
Sbjct: 873 NPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPI--RSHSFRNTILGYFDYAFTAIF 930
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
T+E +LK+ G H A+ RN +N+LD ++V + LVS + +I VK LR RV
Sbjct: 931 TVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAIS--VVKILRVLRV 988
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLR ++ L+ V+ + A+ + +I ++ + ++A IG++LF GK + C D
Sbjct: 989 LRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFY-RCTDE 1047
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
A+ +P C F + + VR N+ + NFDN
Sbjct: 1048 -----AKSNPEEC-----RGLFILYKDGDVDSPVVRERIWQNSDF--------NFDNVLS 1089
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIY---------FVTLVILGSFFVLNLVLG 1095
AM+ +F + EGW ++Y D+ G IY F+ +I+ +FF++N+ +G
Sbjct: 1090 AMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVG 1149
Query: 1096 VLSGEFSKEREK 1131
+ F ++ EK
Sbjct: 1150 FVIVTFQEQGEK 1161
Score = 100 bits (250), Expect = 3e-19
Identities = 71/276 (25%), Positives = 133/276 (47%), Gaps = 1/276 (0%)
Frame = +1
Query: 3277 KAKPHRRYIPRNRL-QYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDV 3453
K+K RR+ NR + R V S F +++ +++ +NT++++ +HY D+
Sbjct: 498 KSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDI 557
Query: 3454 FNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISI 3633
N + +F E ++K+ +L + Y +N FD VV G + +L + + I
Sbjct: 558 ANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEI--MSPLGI 615
Query: 3634 NFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKV 3813
+ FR R++R+ K+ + L+ + + S ++ + LL+ L I++++GMQ FG
Sbjct: 616 SVFRCVRLLRIFKVTRHWTSLCNLVASLLNSMKSSASLLLLLFLFIIIFSLLGMQLFGGK 675
Query: 3814 ALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGL 3993
D T R+ F +FP A+L +F+ TGE W +M GG
Sbjct: 676 FNFDETQTKRST-FDNFPQALLTVFQILTGEDWNAVMYD-------------GIMAYGGP 721
Query: 3994 NESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDN 4101
+ S YFI F+ +++++N+F+A+ +DN
Sbjct: 722 SSS---GMIVCIYFIILFICGNYILLNVFLAIAVDN 754
Score = 92.8 bits (229), Expect = 8e-17
Identities = 76/332 (22%), Positives = 134/332 (39%), Gaps = 35/332 (10%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP + +V PFE+++ +I N + LA+ Q Y + S N ++ + VF VF
Sbjct: 1192 NPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAM-QHY--EQSKMFNDAMDILNMVFTGVF 1248
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMS-------------- 540
T+E VLK++A F P Y +AWN D +IV+ ++ LS+
Sbjct: 1249 TVEMVLKVIA----FKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATP 1304
Query: 541 -----IQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIY 705
+ R FRV+R ++L+S ++ +L ++ L ++ALL+ + IY
Sbjct: 1305 GNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKFFQALPYVALLIAMLFFIY 1364
Query: 706 AIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSS 885
A+IG+++F G++A +D
Sbjct: 1365 AVIGMQMF-------------GKVAMRDNNQI---------------------------- 1383
Query: 886 NTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMY----------------WVNDAV 1017
N NF F A+L +F+C + E W ++M
Sbjct: 1384 --------NRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEHTC 1435
Query: 1018 GREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
G + +YF++ +L +F ++NL + V+ F
Sbjct: 1436 GSNFAIVYFISFYMLCAFLIINLFVAVIMDNF 1467
Score = 88.2 bits (217), Expect = 2e-15
Identities = 78/285 (27%), Positives = 119/285 (41%), Gaps = 39/285 (13%)
Frame = +1
Query: 2323 ASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPL---QANSTRNMIL 2493
A +LF LS N R C +V F +L I + LA P +NST N L
Sbjct: 103 ARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNST-NHNL 161
Query: 2494 NYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL-----RT 2658
+Y F +FTVE LK+I +GL+ H ++ RN +NLLD ++V V L S +L T
Sbjct: 162 EKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKET 221
Query: 2659 DAMSXXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFML 2811
+ + A ++ L+ V+ +I A+ + +I L+ +
Sbjct: 222 EGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFV 281
Query: 2812 QFMFAIIGVQLF-----KGTFFLCNDLSKMTE-----------------AECRGEYIHYE 2925
++AIIG++LF K FF +D+ + ECR ++
Sbjct: 282 IIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPN 341
Query: 2926 DGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLY 3060
G NFDN AM+++F T EGW +LY
Sbjct: 342 GGIT---------------NFDNFAFAMLTVFQCITMEGWTDVLY 371
Score = 87.8 bits (216), Expect = 3e-15
Identities = 145/706 (20%), Positives = 256/706 (35%), Gaps = 80/706 (11%)
Frame = +1
Query: 232 RKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIE 411
R+ C + V+ F +L++ ++ N + ++ D+ + + V + +FT E
Sbjct: 513 RRRCRAAVKSVTFYWLVIVLVFLNTLTISSEH---YNQPDWLTQIQDIANKVLLALFTCE 569
Query: 412 CVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG-FDVKALRAFRVLR 588
++K+ ++G AY + +N D +V G+ TIL ++ I + R R+LR
Sbjct: 570 MLVKMYSLGLQ----AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLR 625
Query: 589 PLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPAT 768
++ SL ++ ++L +M + LL+ I+I++++
Sbjct: 626 IFKVTRHWTSLCNLVASLLNSMKSSASLLLLLFLFIIIFSLL------------------ 667
Query: 769 GQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAM 948
G G F + + + FDNF A+
Sbjct: 668 -----------GMQLFGGKFNFDETQTKRS---------------------TFDNFPQAL 695
Query: 949 LTVFQCVSLEGWTDVMYWVNDAVGREWP-----WIYFVTLVILGSFFVLNLVLGVLSGEF 1113
LTVFQ ++ E W VMY A G IYF+ L I G++ +LN+ L +
Sbjct: 696 LTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNL 755
Query: 1114 S---------------KEREK-ARARGLFQKFREKQQLEE----DLKGYLD-WITQAEDI 1230
+ KER+K AR L K K ++ + D K +D + + ED
Sbjct: 756 ADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDK 815
Query: 1231 EPV----------NEDEQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNX 1380
+P E+E+EDEP P + L K N
Sbjct: 816 DPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIA-PIPEGSAFFILSKTNP 874
Query: 1381 XXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSE-----HYGQSEWLDHFQTMANLFFVIL 1545
L+ F +E H ++ L +F + F +
Sbjct: 875 IRVGCHK-LINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYF----DYAFTAI 929
Query: 1546 FSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSA 1713
F++E+LLKM + G + + FN D VV S++ F + + V +LR
Sbjct: 930 FTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISV---VKILRVL 986
Query: 1714 RLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF----- 1878
R+LR + G+Q+F GKF
Sbjct: 987 RVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTD 1046
Query: 1879 --NFNPQQ---------------PKPRA--------NFDTFVQALLTVFQILTGEDWNTV 1983
NP++ P R NFD + A++ +F + T E W +
Sbjct: 1047 EAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPAL 1106
Query: 1984 MYHGIESFG-GVGTL---GVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+Y I+S G +G + V + I++I+ I + ++N+F+ +
Sbjct: 1107 LYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVI 1152
Score = 81.3 bits (199), Expect = 3e-13
Identities = 80/352 (22%), Positives = 138/352 (38%), Gaps = 53/352 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ F+ I L I N V+LA +P S L+ F +F E LKI+A
Sbjct: 126 KPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGL 185
Query: 3511 -LNPKNYISDRWNVFDLLVVVGSFIDITYGKL---------NPGGTNLISINFFRLFRVM 3660
L+P Y+ + WN+ D ++V+ + +L + G + + R FRV+
Sbjct: 186 LLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVL 245
Query: 3661 RLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF------------ 3804
R ++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F
Sbjct: 246 RPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFAD 305
Query: 3805 -----------------GKVALDDSTSIHRN--------NNFHSFPAAILVLFRSATGEA 3909
G+ + T NF +F A+L +F+ T E
Sbjct: 306 SDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEG 365
Query: 3910 WQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAV 4089
W D++ +D G + YF+S + SF V+NL + V
Sbjct: 366 WTDVLYWMND---------------------AMGFELPWVYFVSLVIFGSFFVLNLVLGV 404
Query: 4090 IMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
+ F G + +R + + D KG +LD +T I P
Sbjct: 405 LSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 450
Score = 68.2 bits (165), Expect = 2e-09
Identities = 54/242 (22%), Positives = 98/242 (40%), Gaps = 29/242 (11%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HY QS+ + + N+ F +F++EM+LK+ + Y + +N FD +VI SI++
Sbjct: 1225 QHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDV 1284
Query: 1657 VLVYFDLMKP------------------LGVSVLRSARLLRIFKVTKYWTXXXXXXXXXX 1782
L D + + ++ R R++R+ K+
Sbjct: 1285 ALSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFI 1344
Query: 1783 XXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILT 1962
GMQ+FG + Q NF TF QA+L +F+ T
Sbjct: 1345 KFFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCAT 1404
Query: 1963 GEDWNTVMYHGIE----------SFGGVGTLGV-IVCIYYIVLFICGNYILLNVFLAIAV 2109
GE W +M + + G T G +Y+I ++ ++++N+F+A+ +
Sbjct: 1405 GEAWQEIMLACLPGKLCDPESDYNPGEEHTCGSNFAIVYFISFYMLCAFLIINLFVAVIM 1464
Query: 2110 DN 2115
DN
Sbjct: 1465 DN 1466
>gi|87002|pir||JH0564 calcium channel alpha-1D chain - human
Length = 2161
Score = 1048 bits (2709), Expect = 0.0
Identities = 525/840 (62%), Positives = 639/840 (75%), Gaps = 16/840 (1%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPRR+SE+ + PIP+ S+ FILS TN RV C+ ++NH FTN +L I++SSA L
Sbjct: 844 RPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAAL 903
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP++++S RN IL YFDY FT++FTVEI LK+ FG HKG+FCRN FNLLD+LVV
Sbjct: 904 AAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVV 963
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
VSL SF +++ A+S AINRAKGLKHVVQCV VA++TIGNIM+VT
Sbjct: 964 GVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTT 1023
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG F+ C D +K ECRG +I Y+DGD PV ++R+W N+DFN
Sbjct: 1024 LLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFN 1083
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP LLY AIDSN E+ GPI+N R +++
Sbjct: 1084 FDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFM 1143
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N QY+ W+ V
Sbjct: 1144 MNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVN 1203
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S+ F D +D+ N++FTGVF E VLK++A PK
Sbjct: 1204 SSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKG 1263
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGGT----------------NLISINFFRLFRV 3657
Y SD WN FD L+V+GS ID+ + +P + N ISI FFRLFRV
Sbjct: 1264 YFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFRLFRV 1323
Query: 3658 MRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSI 3837
MRLVKLLSRGEGIRTLLWTF+K FQALPYVALLI +LFFIYAVIGMQ FGKVA+ D+ I
Sbjct: 1324 MRLVKLLSRGEGIRTLLWTFIKFFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQI 1383
Query: 3838 HRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNN 4017
+RNNNF +FP A+L+LFR ATGEAWQ+IML+C + CDP SD Y+ G E CG+N
Sbjct: 1384 NRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGK--LCDPESD-YNPG--EEHTCGSN 1438
Query: 4018 FAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKG 4197
FA YFISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+WSEYDP+AKG
Sbjct: 1439 FAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKG 1498
Query: 4198 RIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNL 4377
RIKHLDVVTLLR+I PPLGFGKLCPHR+ACKRLV+MNMPLNSDGTV FNATLFALVRT L
Sbjct: 1499 RIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTAL 1558
Query: 4378 KIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFR 4557
KI TEGN+++ANE+LR+ IK+IWK+T LLD+VVPPAG +D+VTVGKFYATFLIQDYFR
Sbjct: 1559 KIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQDYFR 1617
Query: 4558 RFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDEPEPQHR 4737
+FKKRKE G PA+ +ALQAGLRTLH+IGPE++RAIS +L+ DEPE R
Sbjct: 1618 KFKKRKEQGLVGKYPAKN-TTIALQAGLRTLHDIGPEIRRAISCDLQD----DEPEETKR 1672
Score = 714 bits (1843), Expect = 0.0
Identities = 373/669 (55%), Positives = 448/669 (66%), Gaps = 27/669 (4%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
NNPIR+ CISIVEWKPF+ IL I ANC+ALAIY P+P DS+ N LE +EY F+++
Sbjct: 112 NNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLII 171
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQ----------- 546
FT+E LKI+A G + HP+AY+RN WN+LDF+IV++GL S IL +++ +
Sbjct: 172 FTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKS 231
Query: 547 -GFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLE 723
GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+I++AM+PLLHIALLVLFVI+IYAIIGLE
Sbjct: 232 GGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLE 291
Query: 724 LFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPG 903
LF GK+H TC + +A++DP PC G+ +C + + EC S W G
Sbjct: 292 LFIGKMHKTCFFADSDIVAEEDPAPCAFS--GNGRQCTANGT--------ECRSG--WVG 339
Query: 904 PNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLN 1083
PN GITNFDNF AMLTVFQC+++EGWTDV+YW+NDA+G E PW+YFV+LVI GSFFVLN
Sbjct: 340 PNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLN 399
Query: 1084 LVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDE 1263
LVLGVLSGEFSKEREKA+ARG FQK REKQQLEEDLKGYLDWITQAEDI+P NE+E +E
Sbjct: 400 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEE 459
Query: 1264 -------PVAQTXXXXXXXXXX--------XXXXXXXXPSKWAARMKRLEKLNXXXXXXX 1398
P ++T SK + R +R + N
Sbjct: 460 GKRNTSMPTSETESVNTENVSGEGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAA 519
Query: 1399 XXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYS 1578
VKS TFYW +SEHY Q +WL Q +AN + LF+ EML+KMYS
Sbjct: 520 ---VKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYS 576
Query: 1579 LGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXX 1758
LG Y S FNRFDCFVV I E +LV ++M PLG+SV R RLLRIFKVT++WT
Sbjct: 577 LGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSL 636
Query: 1759 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQAL 1938
GMQ+FGGKFNF+ Q K R+ FD F QAL
Sbjct: 637 SNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTK-RSTFDNFPQAL 695
Query: 1939 LTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNL 2118
LTVFQILTGEDWN VMY GI ++GG + G+IVCIY+I+LFICGNYILLNVFLAIAVDNL
Sbjct: 696 LTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNL 755
Query: 2119 ADADSLTNA 2145
ADA+SL A
Sbjct: 756 ADAESLNTA 764
Score = 129 bits (323), Expect = 1e-27
Identities = 92/312 (29%), Positives = 151/312 (47%), Gaps = 9/312 (2%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR C ++ F LIL I + ALA P + ++NT+L +Y F +F
Sbjct: 873 NPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPI--RSHSFRNTILGYFDYAFTAIF 930
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
T+E +LK+ G H A+ RN +N+LD ++V + LVS + +I VK LR RV
Sbjct: 931 TVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAIS--VVKILRVLRV 988
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLR ++ L+ V+ + A+ + +I ++ + ++A IG++LF GK + C D
Sbjct: 989 LRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFY-RCTDE 1047
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
A+ +P C F + + VR N+ + NFDN
Sbjct: 1048 -----AKSNPEEC-----RGLFILYKDGDVDSPVVRERIWQNSDF--------NFDNVLS 1089
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIY---------FVTLVILGSFFVLNLVLG 1095
AM+ +F + EGW ++Y D+ G IY F+ +I+ +FF++N+ +G
Sbjct: 1090 AMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVG 1149
Query: 1096 VLSGEFSKEREK 1131
+ F ++ EK
Sbjct: 1150 FVIVTFQEQGEK 1161
Score = 103 bits (256), Expect = 6e-20
Identities = 71/276 (25%), Positives = 134/276 (47%), Gaps = 1/276 (0%)
Frame = +1
Query: 3277 KAKPHRRYIPRNRL-QYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDV 3453
K+K RR+ NR + R V S F +++ +++ +NT++++ +HY D+
Sbjct: 498 KSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDI 557
Query: 3454 FNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISI 3633
N + +F E ++K+ +L + Y +N FD VV G + +L + + I
Sbjct: 558 ANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEI--MSPLGI 615
Query: 3634 NFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKV 3813
+ FR R++R+ K+ + L+ + + S +++ + LL+ L I++++GMQ FG
Sbjct: 616 SVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGK 675
Query: 3814 ALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGL 3993
D T R+ F +FP A+L +F+ TGE W +M GG
Sbjct: 676 FNFDETQTKRST-FDNFPQALLTVFQILTGEDWNAVMYD-------------GIMAYGGP 721
Query: 3994 NESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDN 4101
+ S YFI F+ +++++N+F+A+ +DN
Sbjct: 722 SSS---GMIVCIYFIILFICGNYILLNVFLAIAVDN 754
Score = 92.8 bits (229), Expect = 8e-17
Identities = 76/332 (22%), Positives = 134/332 (39%), Gaps = 35/332 (10%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP + +V PFE+++ +I N + LA+ Q Y + S N ++ + VF VF
Sbjct: 1192 NPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAM-QHY--EQSKMFNDAMDILNMVFTGVF 1248
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMS-------------- 540
T+E VLK++A F P Y +AWN D +IV+ ++ LS+
Sbjct: 1249 TVEMVLKVIA----FKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATP 1304
Query: 541 -----IQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIY 705
+ R FRV+R ++L+S ++ +L ++ L ++ALL+ + IY
Sbjct: 1305 GNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKFFQALPYVALLIAMLFFIY 1364
Query: 706 AIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSS 885
A+IG+++F G++A +D
Sbjct: 1365 AVIGMQMF-------------GKVAMRDNNQI---------------------------- 1383
Query: 886 NTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMY----------------WVNDAV 1017
N NF F A+L +F+C + E W ++M
Sbjct: 1384 --------NRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEHTC 1435
Query: 1018 GREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
G + +YF++ +L +F ++NL + V+ F
Sbjct: 1436 GSNFAIVYFISFYMLCAFLIINLFVAVIMDNF 1467
Score = 90.5 bits (223), Expect = 4e-16
Identities = 145/706 (20%), Positives = 257/706 (35%), Gaps = 80/706 (11%)
Frame = +1
Query: 232 RKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIE 411
R+ C + V+ F +L++ ++ N + ++ D+ + + V + +FT E
Sbjct: 513 RRRCRAAVKSVTFYWLVIVLVFLNTLTISSEH---YNQPDWLTQIQDIANKVLLALFTCE 569
Query: 412 CVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG-FDVKALRAFRVLR 588
++K+ ++G AY + +N D +V G+ TIL ++ I + R R+LR
Sbjct: 570 MLVKMYSLGLQ----AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLR 625
Query: 589 PLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPAT 768
++ SL ++ ++L +M + + LL+ I+I++++
Sbjct: 626 IFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLL------------------ 667
Query: 769 GQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAM 948
G G F + + + FDNF A+
Sbjct: 668 -----------GMQLFGGKFNFDETQTKRS---------------------TFDNFPQAL 695
Query: 949 LTVFQCVSLEGWTDVMYWVNDAVGREWP-----WIYFVTLVILGSFFVLNLVLGVLSGEF 1113
LTVFQ ++ E W VMY A G IYF+ L I G++ +LN+ L +
Sbjct: 696 LTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNL 755
Query: 1114 S---------------KEREK-ARARGLFQKFREKQQLEE----DLKGYLD-WITQAEDI 1230
+ KER+K AR L K K ++ + D K +D + + ED
Sbjct: 756 ADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDK 815
Query: 1231 EPV----------NEDEQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNX 1380
+P E+E+EDEP P + L K N
Sbjct: 816 DPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIA-PIPEGSAFFILSKTNP 874
Query: 1381 XXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSE-----HYGQSEWLDHFQTMANLFFVIL 1545
L+ F +E H ++ L +F + F +
Sbjct: 875 IRVGCHK-LINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYF----DYAFTAI 929
Query: 1546 FSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSA 1713
F++E+LLKM + G + + FN D VV S++ F + + V +LR
Sbjct: 930 FTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISV---VKILRVL 986
Query: 1714 RLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF----- 1878
R+LR + G+Q+F GKF
Sbjct: 987 RVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTD 1046
Query: 1879 --NFNPQQ---------------PKPRA--------NFDTFVQALLTVFQILTGEDWNTV 1983
NP++ P R NFD + A++ +F + T E W +
Sbjct: 1047 EAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPAL 1106
Query: 1984 MYHGIESFG-GVGTL---GVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+Y I+S G +G + V + I++I+ I + ++N+F+ +
Sbjct: 1107 LYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVI 1152
Score = 88.2 bits (217), Expect = 2e-15
Identities = 78/285 (27%), Positives = 119/285 (41%), Gaps = 39/285 (13%)
Frame = +1
Query: 2323 ASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPL---QANSTRNMIL 2493
A +LF LS N R C +V F +L I + LA P +NST N L
Sbjct: 103 ARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNST-NHNL 161
Query: 2494 NYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL-----RT 2658
+Y F +FTVE LK+I +GL+ H ++ RN +NLLD ++V V L S +L T
Sbjct: 162 EKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKET 221
Query: 2659 DAMSXXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFML 2811
+ + A ++ L+ V+ +I A+ + +I L+ +
Sbjct: 222 EGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFV 281
Query: 2812 QFMFAIIGVQLF-----KGTFFLCNDLSKMTE-----------------AECRGEYIHYE 2925
++AIIG++LF K FF +D+ + ECR ++
Sbjct: 282 IIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPN 341
Query: 2926 DGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLY 3060
G NFDN AM+++F T EGW +LY
Sbjct: 342 GGIT---------------NFDNFAFAMLTVFQCITMEGWTDVLY 371
Score = 81.3 bits (199), Expect = 3e-13
Identities = 80/352 (22%), Positives = 138/352 (38%), Gaps = 53/352 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ F+ I L I N V+LA +P S L+ F +F E LKI+A
Sbjct: 126 KPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGL 185
Query: 3511 -LNPKNYISDRWNVFDLLVVVGSFIDITYGKL---------NPGGTNLISINFFRLFRVM 3660
L+P Y+ + WN+ D ++V+ + +L + G + + R FRV+
Sbjct: 186 LLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVL 245
Query: 3661 RLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF------------ 3804
R ++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F
Sbjct: 246 RPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFAD 305
Query: 3805 -----------------GKVALDDSTSIHRN--------NNFHSFPAAILVLFRSATGEA 3909
G+ + T NF +F A+L +F+ T E
Sbjct: 306 SDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEG 365
Query: 3910 WQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAV 4089
W D++ +D G + YF+S + SF V+NL + V
Sbjct: 366 WTDVLYWMND---------------------AMGFELPWVYFVSLVIFGSFFVLNLVLGV 404
Query: 4090 IMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
+ F G + +R + + D KG +LD +T I P
Sbjct: 405 LSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 450
Score = 68.2 bits (165), Expect = 2e-09
Identities = 54/242 (22%), Positives = 98/242 (40%), Gaps = 29/242 (11%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HY QS+ + + N+ F +F++EM+LK+ + Y + +N FD +VI SI++
Sbjct: 1225 QHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDV 1284
Query: 1657 VLVYFDLMKP------------------LGVSVLRSARLLRIFKVTKYWTXXXXXXXXXX 1782
L D + + ++ R R++R+ K+
Sbjct: 1285 ALSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFI 1344
Query: 1783 XXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILT 1962
GMQ+FG + Q NF TF QA+L +F+ T
Sbjct: 1345 KFFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCAT 1404
Query: 1963 GEDWNTVMYHGIE----------SFGGVGTLGV-IVCIYYIVLFICGNYILLNVFLAIAV 2109
GE W +M + + G T G +Y+I ++ ++++N+F+A+ +
Sbjct: 1405 GEAWQEIMLACLPGKLCDPESDYNPGEEHTCGSNFAIVYFISFYMLCAFLIINLFVAVIM 1464
Query: 2110 DN 2115
DN
Sbjct: 1465 DN 1466
>gi|50754265|ref|XP_429273.1| PREDICTED: hypothetical protein
XP_429273 [Gallus gallus]
Length = 2127
Score = 1047 bits (2707), Expect = 0.0
Identities = 530/866 (61%), Positives = 647/866 (74%), Gaps = 28/866 (3%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPRR+SE+ + PIP+ S+ FI S TN RV C+ ++NH FTN +L I++SS L
Sbjct: 802 RPRRISELNMKEKITPIPEGSAFFIFSSTNPIRVGCHRLINHHIFTNLILVFIMLSSVSL 861
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP++++S RN IL Y DY FTS+FT EI LK+ FG HKGSFCRN FNLLD+LVV
Sbjct: 862 AAEDPIRSHSFRNNILGYADYVFTSMFTFEIILKMTAFGAFLHKGSFCRNYFNLLDLLVV 921
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
VSL SF +++ A+S AINRAKGLKHVVQCV VA++TIGNIM+VT
Sbjct: 922 GVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTT 981
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG F+ C D +K ECRG YI Y+DGD P+ K+RVW N+DFN
Sbjct: 982 LLQFMFACIGVQLFKGKFYKCTDEAKQNPEECRGIYIVYKDGDVDNPMVKERVWQNSDFN 1041
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP LLY AIDSN E+ GP++N R +++
Sbjct: 1042 FDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENVGPVYNYRVEISIFFIIYIIIIAFFM 1101
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N QY+ W+ V
Sbjct: 1102 MNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVN 1161
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPK- 3522
S FEY++F++I++NT+ LA +HY S+ F D +D+ N++FTGVF E VLK++A PK
Sbjct: 1162 STGFEYIMFVLIMLNTLCLAMQHYGQSKLFNDAMDIMNMVFTGVFTVEMVLKLIAFKPKI 1221
Query: 3523 ---------NYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNL--------------ISI 3633
Y SD WN FD L+V+GS +D+ + +P T ISI
Sbjct: 1222 FVRKKERWLGYFSDAWNTFDSLIVIGSIVDVVLSEADPKPTETVTTDESGNSEDSARISI 1281
Query: 3634 NFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKV 3813
FFRLFRVMRLVKLLSRGEGIRTLLWTF+KSFQALPYVALLI +LFFIYAVIGMQ FGKV
Sbjct: 1282 TFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQVFGKV 1341
Query: 3814 ALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGL 3993
A+ D+ I+RNNNF +FP A+L+LFR ATGEAWQ+IML+C + RCDP SD Y+ G
Sbjct: 1342 AMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGK--RCDPESD-YNPG-- 1396
Query: 3994 NESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWS 4173
E CG+NFA YFISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+WS
Sbjct: 1397 EEYTCGSNFAIIYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWS 1456
Query: 4174 EYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATL 4353
EYDP+AKGRIKHLDVVTLLR+I PPLGFGKLCPHR+ACKRLV+MNMPLNSDGTV FNATL
Sbjct: 1457 EYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATL 1516
Query: 4354 FALVRTNLKIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYAT 4533
FALVRT LKI TEGN+++ANE+LR+ IK+IWK+T LLD+VVPPAG +D+VTVGKFYAT
Sbjct: 1517 FALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAG-DDEVTVGKFYAT 1575
Query: 4534 FLIQDYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETD--- 4704
FLIQDYFR+FKKRKE G PA+ +ALQAGLRTLH+IGPE++RAIS +L+ D
Sbjct: 1576 FLIQDYFRKFKKRKEQGLVGKYPAKN-TTIALQAGLRTLHDIGPEIRRAISCDLQDDEPE 1634
Query: 4705 -FNFDEPEPQHRRPHSLFNNLVHRLS 4779
N DE E ++R +LF N ++ +S
Sbjct: 1635 ENNPDEEEEVYKRNGALFGNHINHIS 1660
Score = 707 bits (1826), Expect = 0.0
Identities = 371/695 (53%), Positives = 450/695 (64%), Gaps = 53/695 (7%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
NNPIR+ CIS+VEWKPF+ IL I ANC+ALA+Y P+P DS+ N LE +EY F+++
Sbjct: 44 NNPIRRACISLVEWKPFDIFILLSIFANCVALAVYIPFPEDDSNSTNHNLEKVEYAFLII 103
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQ----------- 546
FT+E LKI+A G + HP+AY+RN WN+LDF+IVV+GL S IL +++ +
Sbjct: 104 FTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVVVGLFSVILEQLTKETEGGSHSGGKP 163
Query: 547 -GFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLE 723
GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+I++AM+PLLHIALLVLFVI+IYAIIGLE
Sbjct: 164 GGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLE 223
Query: 724 LFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPG 903
LF GK+H +C + L ++DP PC G+ +C + + EC W G
Sbjct: 224 LFIGKMHKSCFLIDSDILVEEDPAPCAFS--GNGRQCVMNGT--------ECKGG--WVG 271
Query: 904 PNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLN 1083
PN GITNFDNF AMLTVFQC+++EGWTDV+YWVNDA+G EWPWIYFV+L+ILGSFFVLN
Sbjct: 272 PNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAIGCEWPWIYFVSLIILGSFFVLN 331
Query: 1084 LVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDE 1263
LVLGVLSGEFSKEREKA+ARG FQK REKQQLEEDLKGYLDWITQAEDI+P N++E ++E
Sbjct: 332 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENDEEADEE 391
Query: 1264 ---------------------------------PVAQTXXXXXXXXXX--------XXXX 1320
P ++T
Sbjct: 392 GKRNRVTLADLMEEKKKSRLSCFGRSSNKHASMPTSETESVNTENVSGEGENPACCGSLC 451
Query: 1321 XXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEW 1500
SK++ R +R + N VKS TFYW +SEHY Q +W
Sbjct: 452 QTISKSKFSRRWRRWNRFNRRKCRAA---VKSVTFYWLVIVLVFLNTLTISSEHYNQPDW 508
Query: 1501 LDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLM 1680
L Q +AN + LF+ EML+KMYSLG Y S FNRFDCFVV I+E +LV ++M
Sbjct: 509 LTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGIVETILVELEIM 568
Query: 1681 KPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQ 1860
PLG+SV R RLLRIFKVT++W GMQ
Sbjct: 569 SPLGISVFRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQ 628
Query: 1861 VFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVC 2040
+FGGKFNF+ Q K R+ FD F QALLTVFQILTGEDWN VMY GI ++GG + G+IVC
Sbjct: 629 LFGGKFNFDETQTK-RSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVC 687
Query: 2041 IYYIVLFICGNYILLNVFLAIAVDNLADADSLTNA 2145
IY+I+LFICGNYILLNVFLAIAVDNLADA+SL A
Sbjct: 688 IYFIILFICGNYILLNVFLAIAVDNLADAESLNTA 722
Score = 124 bits (312), Expect = 2e-26
Identities = 90/312 (28%), Positives = 153/312 (48%), Gaps = 9/312 (2%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR C ++ F LIL I + ++LA P + ++N +L +YVF +F
Sbjct: 831 NPIRVGCHRLINHHIFTNLILVFIMLSSVSLAAEDPI--RSHSFRNNILGYADYVFTSMF 888
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
T E +LK+ A G H ++ RN +N+LD ++V + LVS + +I VK LR RV
Sbjct: 889 TFEIILKMTAFGAFLHKGSFCRNYFNLLDLLVVGVSLVSFGIQSSAIS--VVKILRVLRV 946
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLR ++ L+ V+ + A+ + +I ++ + ++A IG++LF GK + C D
Sbjct: 947 LRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYK-CTDE 1005
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
A+++P C + + N V+ W N NFDN
Sbjct: 1006 -----AKQNPEEC-----RGIYIVYKDGDVDNPMVK-----ERVW---QNSDFNFDNVLS 1047
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDAVG---------REWPWIYFVTLVILGSFFVLNLVLG 1095
AM+ +F + EGW ++Y D+ G R I+F+ +I+ +FF++N+ +G
Sbjct: 1048 AMMALFTVSTFEGWPALLYKAIDSNGENVGPVYNYRVEISIFFIIYIIIIAFFMMNIFVG 1107
Query: 1096 VLSGEFSKEREK 1131
+ F ++ E+
Sbjct: 1108 FVIVTFQEQGEQ 1119
Score = 103 bits (258), Expect = 4e-20
Identities = 71/276 (25%), Positives = 134/276 (47%), Gaps = 1/276 (0%)
Frame = +1
Query: 3277 KAKPHRRYIPRNRLQYRVWWF-VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDV 3453
K+K RR+ NR R V S F +++ +++ +NT++++ +HY D+
Sbjct: 456 KSKFSRRWRRWNRFNRRKCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDI 515
Query: 3454 FNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISI 3633
N + +F E ++K+ +L + Y +N FD VV G ++ +L + + I
Sbjct: 516 ANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGIVETILVELEI--MSPLGI 573
Query: 3634 NFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKV 3813
+ FR R++R+ K+ + L+ + + S +++ + LL+ L I++++GMQ FG
Sbjct: 574 SVFRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGK 633
Query: 3814 ALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGL 3993
D T R+ F +FP A+L +F+ TGE W +M GG
Sbjct: 634 FNFDETQTKRST-FDNFPQALLTVFQILTGEDWNAVMYD-------------GIMAYGGP 679
Query: 3994 NESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDN 4101
+ S YFI F+ +++++N+F+A+ +DN
Sbjct: 680 SSS---GMIVCIYFIILFICGNYILLNVFLAIAVDN 712
Score = 89.4 bits (220), Expect = 9e-16
Identities = 79/288 (27%), Positives = 121/288 (41%), Gaps = 39/288 (13%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPL---QANSTRNMILNY 2499
+LF LS N R C +V F +L I + LA P +NST N L
Sbjct: 37 ALFCLSLNNPIRRACISLVEWKPFDIFILLSIFANCVALAVYIPFPEDDSNST-NHNLEK 95
Query: 2500 FDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL-----RTDA 2664
+Y F +FTVE LK+I +GL+ H ++ RN +NLLD ++V V L S +L T+
Sbjct: 96 VEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVVVGLFSVILEQLTKETEG 155
Query: 2665 MSXXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQF 2817
S A ++ L+ V+ +I A+ + +I L+ +
Sbjct: 156 GSHSGGKPGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVII 215
Query: 2818 MFAIIGVQLF-----KGTFFLCNDL-----------------SKMTEAECRGEYIHYEDG 2931
++AIIG++LF K F + +D+ M EC+G ++ G
Sbjct: 216 IYAIIGLELFIGKMHKSCFLIDSDILVEEDPAPCAFSGNGRQCVMNGTECKGGWVGPNGG 275
Query: 2932 DPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
NFDN AM+++F T EGW +LY D+
Sbjct: 276 IT---------------NFDNFAFAMLTVFQCITMEGWTDVLYWVNDA 308
Score = 87.4 bits (215), Expect = 4e-15
Identities = 142/701 (20%), Positives = 252/701 (35%), Gaps = 75/701 (10%)
Frame = +1
Query: 232 RKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIE 411
R+ C + V+ F +L++ ++ N + ++ D+ + + V + +FT E
Sbjct: 471 RRKCRAAVKSVTFYWLVIVLVFLNTLTISSEH---YNQPDWLTQIQDIANKVLLALFTCE 527
Query: 412 CVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG-FDVKALRAFRVLR 588
++K+ ++G AY + +N D +V G+V TIL ++ I + R R+LR
Sbjct: 528 MLVKMYSLGLQ----AYFVSLFNRFDCFVVCGGIVETILVELEIMSPLGISVFRCVRLLR 583
Query: 589 PLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPAT 768
++ SL ++ ++L +M + + LL+ I+I++++
Sbjct: 584 IFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLL------------------ 625
Query: 769 GQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAM 948
G G F + + + FDNF A+
Sbjct: 626 -----------GMQLFGGKFNFDETQTKRS---------------------TFDNFPQAL 653
Query: 949 LTVFQCVSLEGWTDVMYWVNDAVGREWP-----WIYFVTLVILGSFFVLNLVLGVLSGEF 1113
LTVFQ ++ E W VMY A G IYF+ L I G++ +LN+ L +
Sbjct: 654 LTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNL 713
Query: 1114 S---------------KEREK-ARARGLFQKFREK----QQLEEDLKGYLDWITQAEDIE 1233
+ KER+K AR L K EK Q+ +D K + + ED +
Sbjct: 714 ADAESLNTAHKKKTKKKERKKNARKESLENKKSEKSEGDQKKPKDSKVTIAEYGEGEDED 773
Query: 1234 ---------PVNED-EQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXX 1383
PV ED E E++ P + N
Sbjct: 774 KDPYPPCDVPVGEDEEDEEDEPEVPAGPRPRRISELNMKEKITPIPEGSAFFIFSSTNPI 833
Query: 1384 XXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSE-WLDHFQTMANLFFVILFSMEM 1560
L+ F +E +S + ++ A+ F +F+ E+
Sbjct: 834 RVGCHR-LINHHIFTNLILVFIMLSSVSLAAEDPIRSHSFRNNILGYADYVFTSMFTFEI 892
Query: 1561 LLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRI 1728
+LKM + G ++ + FN D VV S++ F + + V +LR R+LR
Sbjct: 893 ILKMTAFGAFLHKGSFCRNYFNLLDLLVVGVSLVSFGIQSSAISV---VKILRVLRVLRP 949
Query: 1729 FKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF-------NFN 1887
+ G+Q+F GKF N
Sbjct: 950 LRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYKCTDEAKQN 1009
Query: 1888 PQQ-----------------PKPRA------NFDTFVQALLTVFQILTGEDWNTVMYHGI 1998
P++ K R NFD + A++ +F + T E W ++Y I
Sbjct: 1010 PEECRGIYIVYKDGDVDNPMVKERVWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAI 1069
Query: 1999 ----ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
E+ G V V + I++I+ I + ++N+F+ +
Sbjct: 1070 DSNGENVGPVYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1110
Score = 84.3 bits (207), Expect = 3e-14
Identities = 85/355 (23%), Positives = 143/355 (39%), Gaps = 56/355 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ F+ I L I N V+LA +P S L+ F +F E LKI+A
Sbjct: 58 KPFDIFILLSIFANCVALAVYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGL 117
Query: 3511 -LNPKNYISDRWNVFDLLVVVGSFIDITYGKLN------------PGGTNLISINFFRLF 3651
L+P Y+ + WN+ D ++VV + +L PGG + R F
Sbjct: 118 LLHPNAYVRNGWNLLDFVIVVVGLFSVILEQLTKETEGGSHSGGKPGG---FDVKALRAF 174
Query: 3652 RVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV----- 3813
RV+R ++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F GK+
Sbjct: 175 RVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKSCF 234
Query: 3814 ALDDSTSIHRN-------------------------------NNFHSFPAAILVLFRSAT 3900
+D + + NF +F A+L +F+ T
Sbjct: 235 LIDSDILVEEDPAPCAFSGNGRQCVMNGTECKGGWVGPNGGITNFDNFAFAMLTVFQCIT 294
Query: 3901 GEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLF 4080
E W D++ +D G + + YF+S +L SF V+NL
Sbjct: 295 MEGWTDVLYWVND---------------------AIGCEWPWIYFVSLIILGSFFVLNLV 333
Query: 4081 VAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
+ V+ F G + +R + + D KG +LD +T I P
Sbjct: 334 LGVLSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 382
Score = 82.4 bits (202), Expect = 1e-13
Identities = 77/340 (22%), Positives = 138/340 (39%), Gaps = 43/340 (12%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP + +V FE+++ +I N + LA+ Q Y S N ++ + VF VF
Sbjct: 1150 NPYQYKFWYVVNSTGFEYIMFVLIMLNTLCLAM-QHYG--QSKLFNDAMDIMNMVFTGVF 1206
Query: 403 TIECVLKIVAMGFMFHPSAYLR----------NAWNILDFIIVVIGLVSTILSKMSIQGF 552
T+E VLK++A F P ++R +AWN D +IV+ +V +LS+ +
Sbjct: 1207 TVEMVLKLIA----FKPKIFVRKKERWLGYFSDAWNTFDSLIVIGSIVDVVLSEADPKPT 1262
Query: 553 D-----------------VKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALL 681
+ + R FRV+R ++L+S ++ +L +++ L ++ALL
Sbjct: 1263 ETVTTDESGNSEDSARISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALL 1322
Query: 682 VLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNM 861
+ + IYA+IG+++F G++A +D
Sbjct: 1323 IAMLFFIYAVIGMQVF-------------GKVAMRDNNQI-------------------- 1349
Query: 862 GVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMY-------------- 999
N NF F A+L +F+C + E W ++M
Sbjct: 1350 ----------------NRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKRCDPESDY 1393
Query: 1000 --WVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
G + IYF++ +L +F ++NL + V+ F
Sbjct: 1394 NPGEEYTCGSNFAIIYFISFYMLCAFLIINLFVAVIMDNF 1433
Score = 69.3 bits (168), Expect = 1e-09
Identities = 62/251 (24%), Positives = 103/251 (40%), Gaps = 38/251 (15%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLG----------FTTYTTSQFNRFDC 1626
+HYGQS+ + + N+ F +F++EM+LK+ + + Y + +N FD
Sbjct: 1183 QHYGQSKLFNDAMDIMNMVFTGVFTVEMVLKLIAFKPKIFVRKKERWLGYFSDAWNTFDS 1242
Query: 1627 FVVISSILEFVLVYFDLMKP-----------------LGVSVLRSARLLRIFKVTKYWTX 1755
+VI SI++ VL D KP + ++ R R++R+ K+
Sbjct: 1243 LIVIGSIVDVVLSEAD-PKPTETVTTDESGNSEDSARISITFFRLFRVMRLVKLLSRGEG 1301
Query: 1756 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQA 1935
GMQVFG + Q NF TF QA
Sbjct: 1302 IRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQVFGKVAMRDNNQINRNNNFQTFPQA 1361
Query: 1936 LLTVFQILTGEDWNTVMYHGI-------ESFGGVG---TLGV-IVCIYYIVLFICGNYIL 2082
+L +F+ TGE W +M + ES G T G IY+I ++ +++
Sbjct: 1362 VLLLFRCATGEAWQEIMLACLPGKRCDPESDYNPGEEYTCGSNFAIIYFISFYMLCAFLI 1421
Query: 2083 LNVFLAIAVDN 2115
+N+F+A+ +DN
Sbjct: 1422 INLFVAVIMDN 1432
>gi|46048807|ref|NP_990365.1| L-type voltage-gated calcium channel
alpha1D subunit ChCaChA1D [Gallus gallus]
gi|6165983|sp|O73700|CCAD_CHICK Voltage-dependent L-type calcium
channel alpha-1D subunit (Voltage-gated calcium channel
alpha subunit Cav1.3) (CHCACHA1D)
gi|2992545|gb|AAC08304.1| L-type voltage-gated calcium channel
alpha1D subunit ChCaChA1D [Gallus gallus]
Length = 2190
Score = 1047 bits (2707), Expect = 0.0
Identities = 530/866 (61%), Positives = 647/866 (74%), Gaps = 28/866 (3%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPRR+SE+ + PIP+ S+ FI S TN RV C+ ++NH FTN +L I++SS L
Sbjct: 865 RPRRISELNMKEKITPIPEGSAFFIFSSTNPIRVGCHRLINHHIFTNLILVFIMLSSVSL 924
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP++++S RN IL Y DY FTS+FT EI LK+ FG HKGSFCRN FNLLD+LVV
Sbjct: 925 AAEDPIRSHSFRNNILGYADYVFTSMFTFEIILKMTAFGAFLHKGSFCRNYFNLLDLLVV 984
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
VSL SF +++ A+S AINRAKGLKHVVQCV VA++TIGNIM+VT
Sbjct: 985 GVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTT 1044
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG F+ C D +K ECRG YI Y+DGD P+ K+RVW N+DFN
Sbjct: 1045 LLQFMFACIGVQLFKGKFYKCTDEAKQNPEECRGIYIVYKDGDVDNPMVKERVWQNSDFN 1104
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP LLY AIDSN E+ GP++N R +++
Sbjct: 1105 FDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENVGPVYNYRVEISIFFIIYIIIIAFFM 1164
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N QY+ W+ V
Sbjct: 1165 MNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVN 1224
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPK- 3522
S FEY++F++I++NT+ LA +HY S+ F D +D+ N++FTGVF E VLK++A PK
Sbjct: 1225 STGFEYIMFVLIMLNTLCLAMQHYGQSKLFNDAMDIMNMVFTGVFTVEMVLKLIAFKPKI 1284
Query: 3523 ---------NYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNL--------------ISI 3633
Y SD WN FD L+V+GS +D+ + +P T ISI
Sbjct: 1285 FVRKKERWLGYFSDAWNTFDSLIVIGSIVDVVLSEADPKPTETVTTDESGNSEDSARISI 1344
Query: 3634 NFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKV 3813
FFRLFRVMRLVKLLSRGEGIRTLLWTF+KSFQALPYVALLI +LFFIYAVIGMQ FGKV
Sbjct: 1345 TFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQVFGKV 1404
Query: 3814 ALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGL 3993
A+ D+ I+RNNNF +FP A+L+LFR ATGEAWQ+IML+C + RCDP SD Y+ G
Sbjct: 1405 AMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGK--RCDPESD-YNPG-- 1459
Query: 3994 NESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWS 4173
E CG+NFA YFISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+WS
Sbjct: 1460 EEYTCGSNFAIIYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWS 1519
Query: 4174 EYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATL 4353
EYDP+AKGRIKHLDVVTLLR+I PPLGFGKLCPHR+ACKRLV+MNMPLNSDGTV FNATL
Sbjct: 1520 EYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATL 1579
Query: 4354 FALVRTNLKIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYAT 4533
FALVRT LKI TEGN+++ANE+LR+ IK+IWK+T LLD+VVPPAG +D+VTVGKFYAT
Sbjct: 1580 FALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAG-DDEVTVGKFYAT 1638
Query: 4534 FLIQDYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETD--- 4704
FLIQDYFR+FKKRKE G PA+ +ALQAGLRTLH+IGPE++RAIS +L+ D
Sbjct: 1639 FLIQDYFRKFKKRKEQGLVGKYPAKN-TTIALQAGLRTLHDIGPEIRRAISCDLQDDEPE 1697
Query: 4705 -FNFDEPEPQHRRPHSLFNNLVHRLS 4779
N DE E ++R +LF N ++ +S
Sbjct: 1698 ENNPDEEEEVYKRNGALFGNHINHIS 1723
Score = 707 bits (1826), Expect = 0.0
Identities = 371/695 (53%), Positives = 450/695 (64%), Gaps = 53/695 (7%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
NNPIR+ CIS+VEWKPF+ IL I ANC+ALA+Y P+P DS+ N LE +EY F+++
Sbjct: 107 NNPIRRACISLVEWKPFDIFILLSIFANCVALAVYIPFPEDDSNSTNHNLEKVEYAFLII 166
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQ----------- 546
FT+E LKI+A G + HP+AY+RN WN+LDF+IVV+GL S IL +++ +
Sbjct: 167 FTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVVVGLFSVILEQLTKETEGGSHSGGKP 226
Query: 547 -GFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLE 723
GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+I++AM+PLLHIALLVLFVI+IYAIIGLE
Sbjct: 227 GGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLE 286
Query: 724 LFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPG 903
LF GK+H +C + L ++DP PC G+ +C + + EC W G
Sbjct: 287 LFIGKMHKSCFLIDSDILVEEDPAPCAFS--GNGRQCVMNGT--------ECKGG--WVG 334
Query: 904 PNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLN 1083
PN GITNFDNF AMLTVFQC+++EGWTDV+YWVNDA+G EWPWIYFV+L+ILGSFFVLN
Sbjct: 335 PNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAIGCEWPWIYFVSLIILGSFFVLN 394
Query: 1084 LVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDE 1263
LVLGVLSGEFSKEREKA+ARG FQK REKQQLEEDLKGYLDWITQAEDI+P N++E ++E
Sbjct: 395 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENDEEADEE 454
Query: 1264 ---------------------------------PVAQTXXXXXXXXXX--------XXXX 1320
P ++T
Sbjct: 455 GKRNRVTLADLMEEKKKSRLSCFGRSSNKHASMPTSETESVNTENVSGEGENPACCGSLC 514
Query: 1321 XXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEW 1500
SK++ R +R + N VKS TFYW +SEHY Q +W
Sbjct: 515 QTISKSKFSRRWRRWNRFNRRKCRAA---VKSVTFYWLVIVLVFLNTLTISSEHYNQPDW 571
Query: 1501 LDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLM 1680
L Q +AN + LF+ EML+KMYSLG Y S FNRFDCFVV I+E +LV ++M
Sbjct: 572 LTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGIVETILVELEIM 631
Query: 1681 KPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQ 1860
PLG+SV R RLLRIFKVT++W GMQ
Sbjct: 632 SPLGISVFRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQ 691
Query: 1861 VFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVC 2040
+FGGKFNF+ Q K R+ FD F QALLTVFQILTGEDWN VMY GI ++GG + G+IVC
Sbjct: 692 LFGGKFNFDETQTK-RSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVC 750
Query: 2041 IYYIVLFICGNYILLNVFLAIAVDNLADADSLTNA 2145
IY+I+LFICGNYILLNVFLAIAVDNLADA+SL A
Sbjct: 751 IYFIILFICGNYILLNVFLAIAVDNLADAESLNTA 785
Score = 124 bits (312), Expect = 2e-26
Identities = 90/312 (28%), Positives = 153/312 (48%), Gaps = 9/312 (2%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR C ++ F LIL I + ++LA P + ++N +L +YVF +F
Sbjct: 894 NPIRVGCHRLINHHIFTNLILVFIMLSSVSLAAEDPI--RSHSFRNNILGYADYVFTSMF 951
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
T E +LK+ A G H ++ RN +N+LD ++V + LVS + +I VK LR RV
Sbjct: 952 TFEIILKMTAFGAFLHKGSFCRNYFNLLDLLVVGVSLVSFGIQSSAIS--VVKILRVLRV 1009
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLR ++ L+ V+ + A+ + +I ++ + ++A IG++LF GK + C D
Sbjct: 1010 LRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYK-CTDE 1068
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
A+++P C + + N V+ W N NFDN
Sbjct: 1069 -----AKQNPEEC-----RGIYIVYKDGDVDNPMVK-----ERVW---QNSDFNFDNVLS 1110
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDAVG---------REWPWIYFVTLVILGSFFVLNLVLG 1095
AM+ +F + EGW ++Y D+ G R I+F+ +I+ +FF++N+ +G
Sbjct: 1111 AMMALFTVSTFEGWPALLYKAIDSNGENVGPVYNYRVEISIFFIIYIIIIAFFMMNIFVG 1170
Query: 1096 VLSGEFSKEREK 1131
+ F ++ E+
Sbjct: 1171 FVIVTFQEQGEQ 1182
Score = 103 bits (258), Expect = 4e-20
Identities = 71/276 (25%), Positives = 134/276 (47%), Gaps = 1/276 (0%)
Frame = +1
Query: 3277 KAKPHRRYIPRNRLQYRVWWF-VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDV 3453
K+K RR+ NR R V S F +++ +++ +NT++++ +HY D+
Sbjct: 519 KSKFSRRWRRWNRFNRRKCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDI 578
Query: 3454 FNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISI 3633
N + +F E ++K+ +L + Y +N FD VV G ++ +L + + I
Sbjct: 579 ANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGIVETILVELEI--MSPLGI 636
Query: 3634 NFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKV 3813
+ FR R++R+ K+ + L+ + + S +++ + LL+ L I++++GMQ FG
Sbjct: 637 SVFRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGK 696
Query: 3814 ALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGL 3993
D T R+ F +FP A+L +F+ TGE W +M GG
Sbjct: 697 FNFDETQTKRST-FDNFPQALLTVFQILTGEDWNAVMYD-------------GIMAYGGP 742
Query: 3994 NESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDN 4101
+ S YFI F+ +++++N+F+A+ +DN
Sbjct: 743 SSS---GMIVCIYFIILFICGNYILLNVFLAIAVDN 775
Score = 89.4 bits (220), Expect = 9e-16
Identities = 79/288 (27%), Positives = 121/288 (41%), Gaps = 39/288 (13%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPL---QANSTRNMILNY 2499
+LF LS N R C +V F +L I + LA P +NST N L
Sbjct: 100 ALFCLSLNNPIRRACISLVEWKPFDIFILLSIFANCVALAVYIPFPEDDSNST-NHNLEK 158
Query: 2500 FDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL-----RTDA 2664
+Y F +FTVE LK+I +GL+ H ++ RN +NLLD ++V V L S +L T+
Sbjct: 159 VEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVVVGLFSVILEQLTKETEG 218
Query: 2665 MSXXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQF 2817
S A ++ L+ V+ +I A+ + +I L+ +
Sbjct: 219 GSHSGGKPGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVII 278
Query: 2818 MFAIIGVQLF-----KGTFFLCNDL-----------------SKMTEAECRGEYIHYEDG 2931
++AIIG++LF K F + +D+ M EC+G ++ G
Sbjct: 279 IYAIIGLELFIGKMHKSCFLIDSDILVEEDPAPCAFSGNGRQCVMNGTECKGGWVGPNGG 338
Query: 2932 DPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
NFDN AM+++F T EGW +LY D+
Sbjct: 339 IT---------------NFDNFAFAMLTVFQCITMEGWTDVLYWVNDA 371
Score = 87.4 bits (215), Expect = 4e-15
Identities = 142/701 (20%), Positives = 252/701 (35%), Gaps = 75/701 (10%)
Frame = +1
Query: 232 RKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIE 411
R+ C + V+ F +L++ ++ N + ++ D+ + + V + +FT E
Sbjct: 534 RRKCRAAVKSVTFYWLVIVLVFLNTLTISSEH---YNQPDWLTQIQDIANKVLLALFTCE 590
Query: 412 CVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG-FDVKALRAFRVLR 588
++K+ ++G AY + +N D +V G+V TIL ++ I + R R+LR
Sbjct: 591 MLVKMYSLGLQ----AYFVSLFNRFDCFVVCGGIVETILVELEIMSPLGISVFRCVRLLR 646
Query: 589 PLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPAT 768
++ SL ++ ++L +M + + LL+ I+I++++
Sbjct: 647 IFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLL------------------ 688
Query: 769 GQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAM 948
G G F + + + FDNF A+
Sbjct: 689 -----------GMQLFGGKFNFDETQTKRS---------------------TFDNFPQAL 716
Query: 949 LTVFQCVSLEGWTDVMYWVNDAVGREWP-----WIYFVTLVILGSFFVLNLVLGVLSGEF 1113
LTVFQ ++ E W VMY A G IYF+ L I G++ +LN+ L +
Sbjct: 717 LTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNL 776
Query: 1114 S---------------KEREK-ARARGLFQKFREK----QQLEEDLKGYLDWITQAEDIE 1233
+ KER+K AR L K EK Q+ +D K + + ED +
Sbjct: 777 ADAESLNTAQKEEAEEKERKKNARKESLENKKSEKSEGDQKKPKDSKVTIAEYGEGEDED 836
Query: 1234 ---------PVNED-EQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXX 1383
PV ED E E++ P + N
Sbjct: 837 KDPYPPCDVPVGEDEEDEEDEPEVPAGPRPRRISELNMKEKITPIPEGSAFFIFSSTNPI 896
Query: 1384 XXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSE-WLDHFQTMANLFFVILFSMEM 1560
L+ F +E +S + ++ A+ F +F+ E+
Sbjct: 897 RVGCHR-LINHHIFTNLILVFIMLSSVSLAAEDPIRSHSFRNNILGYADYVFTSMFTFEI 955
Query: 1561 LLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRI 1728
+LKM + G ++ + FN D VV S++ F + + V +LR R+LR
Sbjct: 956 ILKMTAFGAFLHKGSFCRNYFNLLDLLVVGVSLVSFGIQSSAISV---VKILRVLRVLRP 1012
Query: 1729 FKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF-------NFN 1887
+ G+Q+F GKF N
Sbjct: 1013 LRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYKCTDEAKQN 1072
Query: 1888 PQQ-----------------PKPRA------NFDTFVQALLTVFQILTGEDWNTVMYHGI 1998
P++ K R NFD + A++ +F + T E W ++Y I
Sbjct: 1073 PEECRGIYIVYKDGDVDNPMVKERVWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAI 1132
Query: 1999 ----ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
E+ G V V + I++I+ I + ++N+F+ +
Sbjct: 1133 DSNGENVGPVYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1173
Score = 84.3 bits (207), Expect = 3e-14
Identities = 85/355 (23%), Positives = 143/355 (39%), Gaps = 56/355 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ F+ I L I N V+LA +P S L+ F +F E LKI+A
Sbjct: 121 KPFDIFILLSIFANCVALAVYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGL 180
Query: 3511 -LNPKNYISDRWNVFDLLVVVGSFIDITYGKLN------------PGGTNLISINFFRLF 3651
L+P Y+ + WN+ D ++VV + +L PGG + R F
Sbjct: 181 LLHPNAYVRNGWNLLDFVIVVVGLFSVILEQLTKETEGGSHSGGKPGG---FDVKALRAF 237
Query: 3652 RVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV----- 3813
RV+R ++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F GK+
Sbjct: 238 RVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKSCF 297
Query: 3814 ALDDSTSIHRN-------------------------------NNFHSFPAAILVLFRSAT 3900
+D + + NF +F A+L +F+ T
Sbjct: 298 LIDSDILVEEDPAPCAFSGNGRQCVMNGTECKGGWVGPNGGITNFDNFAFAMLTVFQCIT 357
Query: 3901 GEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLF 4080
E W D++ +D G + + YF+S +L SF V+NL
Sbjct: 358 MEGWTDVLYWVND---------------------AIGCEWPWIYFVSLIILGSFFVLNLV 396
Query: 4081 VAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
+ V+ F G + +R + + D KG +LD +T I P
Sbjct: 397 LGVLSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 445
Score = 82.4 bits (202), Expect = 1e-13
Identities = 77/340 (22%), Positives = 138/340 (39%), Gaps = 43/340 (12%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP + +V FE+++ +I N + LA+ Q Y S N ++ + VF VF
Sbjct: 1213 NPYQYKFWYVVNSTGFEYIMFVLIMLNTLCLAM-QHYG--QSKLFNDAMDIMNMVFTGVF 1269
Query: 403 TIECVLKIVAMGFMFHPSAYLR----------NAWNILDFIIVVIGLVSTILSKMSIQGF 552
T+E VLK++A F P ++R +AWN D +IV+ +V +LS+ +
Sbjct: 1270 TVEMVLKLIA----FKPKIFVRKKERWLGYFSDAWNTFDSLIVIGSIVDVVLSEADPKPT 1325
Query: 553 D-----------------VKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALL 681
+ + R FRV+R ++L+S ++ +L +++ L ++ALL
Sbjct: 1326 ETVTTDESGNSEDSARISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALL 1385
Query: 682 VLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNM 861
+ + IYA+IG+++F G++A +D
Sbjct: 1386 IAMLFFIYAVIGMQVF-------------GKVAMRDNNQI-------------------- 1412
Query: 862 GVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMY-------------- 999
N NF F A+L +F+C + E W ++M
Sbjct: 1413 ----------------NRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKRCDPESDY 1456
Query: 1000 --WVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
G + IYF++ +L +F ++NL + V+ F
Sbjct: 1457 NPGEEYTCGSNFAIIYFISFYMLCAFLIINLFVAVIMDNF 1496
Score = 69.3 bits (168), Expect = 1e-09
Identities = 62/251 (24%), Positives = 103/251 (40%), Gaps = 38/251 (15%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLG----------FTTYTTSQFNRFDC 1626
+HYGQS+ + + N+ F +F++EM+LK+ + + Y + +N FD
Sbjct: 1246 QHYGQSKLFNDAMDIMNMVFTGVFTVEMVLKLIAFKPKIFVRKKERWLGYFSDAWNTFDS 1305
Query: 1627 FVVISSILEFVLVYFDLMKP-----------------LGVSVLRSARLLRIFKVTKYWTX 1755
+VI SI++ VL D KP + ++ R R++R+ K+
Sbjct: 1306 LIVIGSIVDVVLSEAD-PKPTETVTTDESGNSEDSARISITFFRLFRVMRLVKLLSRGEG 1364
Query: 1756 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQA 1935
GMQVFG + Q NF TF QA
Sbjct: 1365 IRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQVFGKVAMRDNNQINRNNNFQTFPQA 1424
Query: 1936 LLTVFQILTGEDWNTVMYHGI-------ESFGGVG---TLGV-IVCIYYIVLFICGNYIL 2082
+L +F+ TGE W +M + ES G T G IY+I ++ +++
Sbjct: 1425 VLLLFRCATGEAWQEIMLACLPGKRCDPESDYNPGEEYTCGSNFAIIYFISFYMLCAFLI 1484
Query: 2083 LNVFLAIAVDN 2115
+N+F+A+ +DN
Sbjct: 1485 INLFVAVIMDN 1495
>gi|47218490|emb|CAF97224.1| unnamed protein product [Tetraodon
nigroviridis]
Length = 1327
Score = 1036 bits (2680), Expect = 0.0
Identities = 514/860 (59%), Positives = 651/860 (74%), Gaps = 16/860 (1%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPR +S++ V P+P+A + F+ SHTN FR+ C+ +VNH+ FTN +LF IL+SS L
Sbjct: 61 RPRPLSDIQLKEKVVPMPEARAFFVFSHTNKFRITCHKIVNHNIFTNLILFFILLSSISL 120
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP++ +S+RN IL Y D+ FT +FT+EI LK+ +G HKGSFCRN FN+LD++VV
Sbjct: 121 AAEDPVKYDSSRNQILGYADHVFTGLFTIEIILKMTAYGAFLHKGSFCRNYFNILDLVVV 180
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
+VSL S +++ A++ AINRAKGLKHVVQCV VA++TIGNI++VT
Sbjct: 181 SVSLISSGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 240
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG FF C D SK T+AECRG YI Y+DGD KP +R+W N++FN
Sbjct: 241 LLQFMFACIGVQLFKGKFFSCTDNSKQTQAECRGSYIEYKDGDVGKPERAQRIWKNSEFN 300
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV M++LF VSTFEGWP LLY AIDS ED GPI+N R +++
Sbjct: 301 FDNVLQGMMALFAVSTFEGWPGLLYRAIDSVAEDVGPIYNYRVIISIFFIIYIIIIAFFM 360
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N QY+VW+ V
Sbjct: 361 MNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKVWYVVN 420
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F +I++NT+ LA +H+ ++ F + +++ N++FTG+F E +LK++A P+
Sbjct: 421 STYFEYLMFTLILLNTICLAMQHHGQTKSFNNAMNILNMLFTGLFTVEMILKLIAFKPRG 480
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGGTNL-ISINFFRLFRVMRLVKLLSRGEGIRT 3702
Y SD WNVFD L+V+GS ID+ ++N N ISI FFRLFRVMRLVKLLSRGEGIRT
Sbjct: 481 YFSDPWNVFDFLIVIGSIIDVILSEINNSEENARISITFFRLFRVMRLVKLLSRGEGIRT 540
Query: 3703 LLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILV 3882
LLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL D+T I+RNNNF +FP A+L+
Sbjct: 541 LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALRDNTEINRNNNFQTFPQAVLL 600
Query: 3883 LFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESR-----CGNNFAYPYFISFF 4047
LFR ATGEAWQ+IML+C+ C+ KG NE+ CG++FA YF+SF+
Sbjct: 601 LFRCATGEAWQEIMLACTPNRP--CE-------KGSTNETNQSAEDCGSHFAIIYFVSFY 651
Query: 4048 MLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTL 4227
MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+W+EYDP+AKGRIKHLDVVTL
Sbjct: 652 MLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTL 711
Query: 4228 LRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNIDE 4407
LR+I PPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFALVRT L+I TEGN+++
Sbjct: 712 LRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQ 771
Query: 4408 ANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEMEA 4587
ANE+LR+ +K+IWKRT LLD+VVPPAG +D+VTVGKFYATFLIQ+YFR+FKKRKE
Sbjct: 772 ANEELRAIVKKIWKRTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQEYFRKFKKRKEQGL 830
Query: 4588 KGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNL----ETDFNFDEP------EPQHR 4737
+P +T ++LQAGLRTLH+IGPE++RAISG+L E D EP + R
Sbjct: 831 VAKVPPKT--TLSLQAGLRTLHDIGPEIRRAISGDLTVEEELDKGLKEPVSAASEDDIFR 888
Query: 4738 RPHSLFNNLVHRLSGAGSKS 4797
R +F+N V+ + + +S
Sbjct: 889 RTGGVFSNHVNYYNQSDGRS 908
Score = 125 bits (315), Expect = 9e-27
Identities = 97/341 (28%), Positives = 158/341 (45%), Gaps = 9/341 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V N R C IV F LILF I + I+L
Sbjct: 61 RPRPLSDIQLKEKVVPMPEARAFFVFSHTNKFRITCHKIVNHNIFTNLILFFILLSSISL 120
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P S +N +L ++VF +FTIE +LK+ A G H ++ RN +NILD +
Sbjct: 121 AAEDPVKYDSS--RNQILGYADHVFTGLFTIEIILKMTAYGAFLHKGSFCRNYFNILDLV 178
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S+ + +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 179 VVSVSLISSGIQSSAIN--VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIV 236
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLT 855
++ + ++A IG++LF GK S C D + A + GS + + D
Sbjct: 237 IVTTLLQFMFACIGVQLFKGKFFS-CTDNSKQTQA---------ECRGSYIEYKDGD--- 283
Query: 856 NMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPW 1035
V + W N NFDN M+ +F + EGW ++Y D+V +
Sbjct: 284 ---VGKPERAQRIW---KNSEFNFDNVLQGMMALFAVSTFEGWPGLLYRAIDSVAEDVGP 337
Query: 1036 IY---------FVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
IY F+ +I+ +FF++N+ +G + F ++ E+
Sbjct: 338 IYNYRVIISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 378
Score = 100 bits (248), Expect = 5e-19
Identities = 76/318 (23%), Positives = 139/318 (42%), Gaps = 21/318 (6%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP + +V FE+L+ +I N I LA+ + Q + N + + +F +F
Sbjct: 409 NPYQYKVWYVVNSTYFEYLMFTLILLNTICLAMQ--HHGQTKSFNNAM-NILNMLFTGLF 465
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG----FDVKALR 570
T+E +LK++A F P Y + WN+ DF+IV+ ++ ILS+++ + R
Sbjct: 466 TVEMILKLIA----FKPRGYFSDPWNVFDFLIVIGSIIDVILSEINNSEENARISITFFR 521
Query: 571 AFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHST 750
FRV+R ++L+S ++ +L +++ L ++ALL++ + IYA+IG+++F
Sbjct: 522 LFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMF------- 574
Query: 751 CIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFD 930
G++A +D T N NF
Sbjct: 575 ------GKIALRDNTEI------------------------------------NRNNNFQ 592
Query: 931 NFGLAMLTVFQCVSLEGWTDVMYWVN-----------------DAVGREWPWIYFVTLVI 1059
F A+L +F+C + E W ++M + G + IYFV+ +
Sbjct: 593 TFPQAVLLLFRCATGEAWQEIMLACTPNRPCEKGSTNETNQSAEDCGSHFAIIYFVSFYM 652
Query: 1060 LGSFFVLNLVLGVLSGEF 1113
L +F ++NL + V+ F
Sbjct: 653 LCAFLIINLFVAVIMDNF 670
Score = 71.2 bits (173), Expect = 3e-10
Identities = 52/230 (22%), Positives = 101/230 (43%), Gaps = 17/230 (7%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+H+GQ++ ++ + N+ F LF++EM+LK+ + Y + +N FD +VI SI++
Sbjct: 442 QHHGQTKSFNNAMNILNMLFTGLFTVEMILKLIAFKPRGYFSDPWNVFDFLIVIGSIIDV 501
Query: 1657 VLVYFDLMKP---LGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXX 1827
+L + + + ++ R R++R+ K+
Sbjct: 502 ILSEINNSEENARISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVM 561
Query: 1828 XXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMY------ 1989
GMQ+FG + + NF TF QA+L +F+ TGE W +M
Sbjct: 562 LFFIYAVIGMQMFGKIALRDNTEINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACTPNR 621
Query: 1990 --------HGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDN 2115
+S G+ I IY++ ++ ++++N+F+A+ +DN
Sbjct: 622 PCEKGSTNETNQSAEDCGSHFAI--IYFVSFYMLCAFLIINLFVAVIMDN 669
Score = 44.7 bits (104), Expect = 0.027
Identities = 49/234 (20%), Positives = 87/234 (36%), Gaps = 38/234 (16%)
Frame = +1
Query: 1522 ANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPL 1689
A+ F LF++E++LKM + G ++ + FN D VV S++ + +
Sbjct: 139 ADHVFTGLFTIEIILKMTAYGAFLHKGSFCRNYFNILDLVVVSVSLISSGIQSSAINV-- 196
Query: 1690 GVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFG 1869
V +LR R+LR + G+Q+F
Sbjct: 197 -VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFK 255
Query: 1870 GKF-----NFNPQQPKPRA-------------------------NFDTFVQALLTVFQIL 1959
GKF N Q + R NFD +Q ++ +F +
Sbjct: 256 GKFFSCTDNSKQTQAECRGSYIEYKDGDVGKPERAQRIWKNSEFNFDNVLQGMMALFAVS 315
Query: 1960 TGEDWNTVMYHGIES----FGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
T E W ++Y I+S G + VI+ I++I+ I + ++N+F+ +
Sbjct: 316 TFEGWPGLLYRAIDSVAEDVGPIYNYRVIISIFFIIYIIIIAFFMMNIFVGFVI 369
>gi|116411|sp|P15381|CCAC_RABIT Voltage-dependent L-type calcium
channel alpha-1C subunit (Voltage-gated calcium channel
alpha subunit Cav1.2) (Calcium channel, L type, alpha-1
polypeptide, isoform 1, cardiac muscle) (Smooth muscle
calcium channel blocker receptor) (CACB-receptor)
gi|89942|pir||S05054 calcium channel alpha-1 chain, dihydropyridine
sensitive, cardiac (clone lambda-CCAR34) - rabbit
gi|1510|emb|CAA33546.1| unnamed protein product [Oryctolagus
cuniculus]
gi|226427|prf||1512308A dihydropyridine sensitive Ca channel
Length = 2171
Score = 1030 bits (2664), Expect = 0.0
Identities = 512/830 (61%), Positives = 640/830 (76%), Gaps = 12/830 (1%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPR +SE+ P+P+AS+ FI S N FR+ C+ +VN + FTN +LF IL+SS L
Sbjct: 888 RPRPLSELHLKEKAVPMPEASAFFIFSPNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 947
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP+Q S RN IL YFD FT++FT+EI LK+ +G HKGSFCRN FN+LD+LVV
Sbjct: 948 AAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVV 1007
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
+VSL SF +++ A++ AINRAKGLKHVVQCV VA++TIGNI++VT
Sbjct: 1008 SVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 1067
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG + C+D SK TEAEC+G YI Y+DG+ P+ + R W N+ F+
Sbjct: 1068 LLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFD 1127
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP+LLY +IDS+ EDKGPI+N R +++
Sbjct: 1128 FDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFM 1187
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N+ QY+VW+ V
Sbjct: 1188 MNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVN 1247
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S F+ +++ N++FTG+F E +LK++A PK
Sbjct: 1248 STYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKG 1307
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGG------------TNLISINFFRLFRVMRLV 3669
Y SD WNVFD L+V+GS ID+ + NP + ISI FFRLFRVMRLV
Sbjct: 1308 YFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLV 1367
Query: 3670 KLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNN 3849
KLLSRGEGIRTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL+D+T I+RNN
Sbjct: 1368 KLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNN 1427
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FP A+L+LFR ATGEAWQDIML+C + +C P S+ H E+ CG++FA
Sbjct: 1428 NFQTFPQAVLLLFRCATGEAWQDIMLACMPGK--KCAPESEP-HNSTEGETPCGSSFAVF 1484
Query: 4030 YFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKH 4209
YFISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+W+EYDP+AKGRIKH
Sbjct: 1485 YFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKH 1544
Query: 4210 LDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYT 4389
LDVVTLLR+I PPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFALVRT L+I T
Sbjct: 1545 LDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKT 1604
Query: 4390 EGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKK 4569
EGN+++ANE+LR+ IK+IWKRT LLD+VVPPAG +D+VTVGKFYATFLIQ+YFR+FKK
Sbjct: 1605 EGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQEYFRKFKK 1663
Query: 4570 RKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDE 4719
RKE G P+Q A++LQAGLRTLH+IGPE++RAISG+L + D+
Sbjct: 1664 RKEQGLVG-KPSQR-NALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDK 1711
Score = 708 bits (1827), Expect = 0.0
Identities = 377/698 (54%), Positives = 455/698 (65%), Gaps = 28/698 (4%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXX-XXXNNPIRKLCISIVEWKPFEFLILFMICANCIA 312
+KR KP +Q + NPIR+ CISIVEWKPFE +IL I ANC+A
Sbjct: 111 RKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVA 170
Query: 313 LAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDF 492
LAIY P+P DS+ N+ LE +EY+F+++FT+E LK++A G +FHP+AYLRN WN+LDF
Sbjct: 171 LAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDF 230
Query: 493 IIVVIGLVSTILSKMSIQ-----------GFDVKALRAFRVLRPLRLVSGVPSLQVVLNA 639
IIVV+GL S IL + + GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+
Sbjct: 231 IIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNS 290
Query: 640 ILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP--ATGQLAQKDPTPCGTDT 813
I++AM+PLLHIALLVLFVI+IYAIIGLELF GK+H TC + A+ DP+PC +T
Sbjct: 291 IIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGVADVPAEDDPSPCALET 350
Query: 814 EGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDV 993
G +CQ + ++ G W GP +GITNFDNF AMLTVFQC+++EGWTDV
Sbjct: 351 -GHGRQCQ-NGTVCKPG----------WDGPKHGITNFDNFAFAMLTVFQCITMEGWTDV 398
Query: 994 MYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQ 1173
+YW+ DA+G E PW+YFV+LVI GSFFVLNLVLGVLSGEFSKEREKA+ARG FQK REKQ
Sbjct: 399 LYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 458
Query: 1174 QLEEDLKGYLDWITQAEDIEPVNEDEQEDE--------PVAQTXXXXXXXXXXXXXXXXX 1329
QLEEDLKGYLDWITQAEDI+P NEDE DE P ++T
Sbjct: 459 QLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGEN 518
Query: 1330 XPSKWAARMKRLE------KLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQ 1491
++ A R+ + + + N VKS FYW SEHY Q
Sbjct: 519 CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQ 578
Query: 1492 SEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYF 1671
WL Q AN + LF+ EMLLKMYSLG Y S FNRFDCF+V ILE +LV
Sbjct: 579 PHWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFIVCGGILETILVET 638
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+M PLG+SVLR RLLRIFK+T+YW
Sbjct: 639 KVMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 698
Query: 1852 GMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGV 2031
GMQ+FGGKFNF+ Q + R+ FD F Q+LLTVFQILTGEDWN+VMY GI ++GG G+
Sbjct: 699 GMQLFGGKFNFDEMQTR-RSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGM 757
Query: 2032 IVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNA 2145
+VCIY+I+LFICGNYILLNVFLAIAVDNLADA+SLT+A
Sbjct: 758 LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSA 795
Score = 127 bits (318), Expect = 4e-27
Identities = 100/342 (29%), Positives = 160/342 (46%), Gaps = 10/342 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V NN R C IV F LILF I + I+L
Sbjct: 888 RPRPLSELHLKEKAVPMPEASAFFIFSPNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 947
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P Q + ++N +L + VF +FTIE LK+ A G H ++ RN +NILD +
Sbjct: 948 AAEDP--VQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLL 1005
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S + +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 1006 VVSVSLISFGIQSSAINV--VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIV 1063
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ-KDPTPCGTDTEGSAFKCQPSDSL 852
++ + ++A IG++LF GKL+ TC D + A+ K D E QP
Sbjct: 1064 IVTTLLQFMFACIGVQLFKGKLY-TCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRS-- 1120
Query: 853 TNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWP 1032
WE N +FDN AM+ +F + EGW +++Y D+ +
Sbjct: 1121 ------WE-----------NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKG 1163
Query: 1033 WIY---------FVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
IY F+ +I+ +FF++N+ +G + F ++ E+
Sbjct: 1164 PIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1205
Score = 95.9 bits (237), Expect = 1e-17
Identities = 63/259 (24%), Positives = 124/259 (47%), Gaps = 5/259 (1%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S F +++ ++ +NT+++A +HY + D N +F E +LK+ +L
Sbjct: 551 VKSNVFYWLVIFLVFLNTLTIASEHYNQPHWLTEVQDTANKALLALFTAEMLLKMYSLGL 610
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD +V G ++ + + + I+ R R++R+ K+ +
Sbjct: 611 QAYFVSLFNRFDCFIVCGGILETIL--VETKVMSPLGISVLRCVRLLRIFKITRYWNSLS 668
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + + S +++ + LL+ L I++++GMQ F GK D+ + R + F +FP ++
Sbjct: 669 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT--RRSTFDNFPQSL 726
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNF----AYPYFISF 4044
L +F+ TGE W +M D G G +F YFI
Sbjct: 727 LTVFQILTGEDWNSVMY--------------DGIMAYG------GPSFPGMLVCIYFIIL 766
Query: 4045 FMLCSFLVINLFVAVIMDN 4101
F+ +++++N+F+A+ +DN
Sbjct: 767 FICGNYILLNVFLAIAVDN 785
Score = 89.7 bits (221), Expect = 7e-16
Identities = 74/315 (23%), Positives = 131/315 (41%), Gaps = 33/315 (10%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+L+ +I N I LA+ Q Y Q +K + + +F +FT+E +LK++A F
Sbjct: 1251 FEYLMFVLILLNTICLAM-QHY-GQSCLFK-IAMNILNMLFTGLFTVEMILKLIA----F 1303
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMSI---------------QGFDVKALRAFRV 582
P Y + WN+ DF+IV+ ++ ILS+ + + R FRV
Sbjct: 1304 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRV 1363
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
+R ++L+S ++ +L +++ L ++ALL++ + IYA+IG+++F
Sbjct: 1364 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF----------- 1412
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
G++A D T N NF F
Sbjct: 1413 --GKIALNDTTEI------------------------------------NRNNNFQTFPQ 1434
Query: 943 AMLTVFQCVSLEGWTDVMYWV------------------NDAVGREWPWIYFVTLVILGS 1068
A+L +F+C + E W D+M G + YF++ +L +
Sbjct: 1435 AVLLLFRCATGEAWQDIMLACMPGKKCAPESEPHNSTEGETPCGSSFAVFYFISFYMLCA 1494
Query: 1069 FFVLNLVLGVLSGEF 1113
F ++NL + V+ F
Sbjct: 1495 FLIINLFVAVIMDNF 1509
Score = 89.4 bits (220), Expect = 9e-16
Identities = 89/353 (25%), Positives = 144/353 (40%), Gaps = 54/353 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE +I L I N V+LA +P S L+ +F +F EA LK++A
Sbjct: 154 KPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGL 213
Query: 3511 -LNPKNYISDRWNVFD-LLVVVGSFIDITYGKLNPGGTNLIS-------INFFRLFRVMR 3663
+P Y+ + WN+ D ++VVVG F I G N + + R FRV+R
Sbjct: 214 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLR 273
Query: 3664 LVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV--------- 3813
++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F GK+
Sbjct: 274 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEG 333
Query: 3814 -----ALDDSTSI------------------------HRNNNFHSFPAAILVLFRSATGE 3906
A DD + H NF +F A+L +F+ T E
Sbjct: 334 VADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITME 393
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVA 4086
W D++ D G + YF+S + SF V+NL +
Sbjct: 394 GWTDVLYWMQD---------------------AMGYELPWVYFVSLVIFGSFFVLNLVLG 432
Query: 4087 VIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
V+ F G + +R + + D KG +LD +T I P
Sbjct: 433 VLSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 479
Score = 88.2 bits (217), Expect = 2e-15
Identities = 75/273 (27%), Positives = 119/273 (43%), Gaps = 29/273 (10%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR--NMILNYF 2502
+L L+ N R C +V F +L I + LA P + + N L
Sbjct: 133 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 192
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL----RTDAMS 2670
+Y F +FTVE LKVI +GL+FH ++ RN +NLLD ++V V L S +L + D +
Sbjct: 193 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 252
Query: 2671 XXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
A ++ L+ V+ +I A+ + +I L+ + ++
Sbjct: 253 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 312
Query: 2824 AIIGVQLFKGTFF-LCNDLSKMTE-------AECRGEYIH---YEDGDPTKPVSKKRVW- 2967
AIIG++LF G C + + + + C E H ++G KP W
Sbjct: 313 AIIGLELFMGKMHKTCYNQEGVADVPAEDDPSPCALETGHGRQCQNGTVCKP-----GWD 367
Query: 2968 --SNNDFNFDNVGDAMISLFVVSTFEGWPQLLY 3060
+ NFDN AM+++F T EGW +LY
Sbjct: 368 GPKHGITNFDNFAFAMLTVFQCITMEGWTDVLY 400
Score = 70.1 bits (170), Expect = 6e-10
Identities = 57/240 (23%), Positives = 98/240 (40%), Gaps = 27/240 (11%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HYGQS + N+ F LF++EM+LK+ + Y + +N FD +VI SI++
Sbjct: 1269 QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDV 1328
Query: 1657 VL--------------VYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXX 1794
+L + + + ++ R R++R+ K+
Sbjct: 1329 ILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQ 1388
Query: 1795 XXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDW 1974
GMQVFG + + NF TF QA+L +F+ TGE W
Sbjct: 1389 ALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAW 1448
Query: 1975 NTVMYHGI-------ESFGGVGTLGVIVC------IYYIVLFICGNYILLNVFLAIAVDN 2115
+M + ES T G C Y+I ++ ++++N+F+A+ +DN
Sbjct: 1449 QDIMLACMPGKKCAPESEPHNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDN 1508
Score = 41.2 bits (95), Expect = 0.29
Identities = 46/240 (19%), Positives = 87/240 (36%), Gaps = 38/240 (15%)
Frame = +1
Query: 1504 DHFQTMANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYF 1671
+H ++ F +F++E+ LKM + G ++ + FN D VV S++ F +
Sbjct: 960 NHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS 1019
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+ V +LR R+LR +
Sbjct: 1020 AINV---VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACI 1076
Query: 1852 GMQVFGGKFNFNPQQPK------------------------PRA------NFDTFVQALL 1941
G+Q+F GK K PR+ +FD + A++
Sbjct: 1077 GVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMM 1136
Query: 1942 TVFQILTGEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+F + T E W ++Y I+S G + V + I++I+ I + ++N+F+ +
Sbjct: 1137 ALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1196
>gi|6470279|gb|AAF13708.1| calcium channel [Oryctolagus cuniculus]
Length = 909
Score = 1030 bits (2663), Expect = 0.0
Identities = 510/819 (62%), Positives = 639/819 (77%), Gaps = 1/819 (0%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPR +SE+ P+P+AS+ FI S N FR+ C+ +VN + FTN +LF IL+SS L
Sbjct: 97 RPRPLSELHLKEKAVPMPEASAFFIFSPNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 156
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP+Q S RN IL YFD FT++FT+EI LK+ +G HKGSFCRN FN+LD+LVV
Sbjct: 157 AAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVV 216
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
+VSL SF +++ A++ AINRAKGLKHVVQCV VA++TIGNI++VT
Sbjct: 217 SVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 276
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG + C+D SK TEAEC+G YI Y+DG+ P+ + R W N+ F+
Sbjct: 277 LLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFD 336
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP+LLY +IDS+ EDKGPI+N R +++
Sbjct: 337 FDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFM 396
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKN+R+C+E+ALKA+P RRYIP+N+ QY+VW+ V
Sbjct: 397 MNIFVGFVIVTFQEQGEQEYKNCELDKNRRQCVEYALKARPLRRYIPKNQHQYKVWYVVN 456
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S F+ +++ N++FTG+F E +LK++A PK
Sbjct: 457 STYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKG 516
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGGTNL-ISINFFRLFRVMRLVKLLSRGEGIRT 3702
Y SD WNVFD LVV+GS ID+ + N N ISI FFRLFRVMRLVKLL+RGEGIRT
Sbjct: 517 YFSDPWNVFDFLVVIGSIIDVILSETNNAEENSRISITFFRLFRVMRLVKLLTRGEGIRT 576
Query: 3703 LLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILV 3882
LLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL+D+T I+RNNNF +FP A+L+
Sbjct: 577 LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLL 636
Query: 3883 LFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSF 4062
LFR ATGEAWQDIML+C + +C P S+ H E+ CG++FA YFISF+MLC+F
Sbjct: 637 LFRCATGEAWQDIMLACMPGK--KCAPESEP-HNSTEGETPCGSSFAVFYFISFYMLCAF 693
Query: 4063 LVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKIS 4242
L+INLFVA+IMDNFDYLTRDWSILGPHHL+EF R+W+EYDP+AKGRIKHLDVVTLLR+I
Sbjct: 694 LIINLFVAIIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQ 753
Query: 4243 PPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNIDEANEQL 4422
PPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFALVRT L+I TEGN+++ANE+L
Sbjct: 754 PPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEEL 813
Query: 4423 RSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEMEAKGVLP 4602
R+ IK+IWKRT LLD+VVPPAG +D+VTVGKFYATFLIQ+YFR+FKKRKE G P
Sbjct: 814 RAIIKKIWKRTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQEYFRKFKKRKEQGLVG-KP 871
Query: 4603 AQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDE 4719
+Q A++LQAGLRTLH+IGPE++RAISG+L + D+
Sbjct: 872 SQR-NALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDK 909
Score = 127 bits (318), Expect = 4e-27
Identities = 100/342 (29%), Positives = 160/342 (46%), Gaps = 10/342 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V NN R C IV F LILF I + I+L
Sbjct: 97 RPRPLSELHLKEKAVPMPEASAFFIFSPNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 156
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P Q + ++N +L + VF +FTIE LK+ A G H ++ RN +NILD +
Sbjct: 157 AAEDP--VQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLL 214
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S + +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 215 VVSVSLISFGIQSSAINV--VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIV 272
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ-KDPTPCGTDTEGSAFKCQPSDSL 852
++ + ++A IG++LF GKL+ TC D + A+ K D E QP
Sbjct: 273 IVTTLLQFMFACIGVQLFKGKLY-TCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRS-- 329
Query: 853 TNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWP 1032
WE N +FDN AM+ +F + EGW +++Y D+ +
Sbjct: 330 ------WE-----------NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKG 372
Query: 1033 WIY---------FVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
IY F+ +I+ +FF++N+ +G + F ++ E+
Sbjct: 373 PIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 414
Score = 92.0 bits (227), Expect = 1e-16
Identities = 71/304 (23%), Positives = 131/304 (42%), Gaps = 22/304 (7%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+L+ +I N I LA+ Q Y Q +K + + +F +FT+E +LK++A F
Sbjct: 460 FEYLMFVLILLNTICLAM-QHY-GQSCLFK-IAMNILNMLFTGLFTVEMILKLIA----F 512
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMSI----QGFDVKALRAFRVLRPLRLVSGVP 615
P Y + WN+ DF++V+ ++ ILS+ + + R FRV+R ++L++
Sbjct: 513 KPKGYFSDPWNVFDFLVVIGSIIDVILSETNNAEENSRISITFFRLFRVMRLVKLLTRGE 572
Query: 616 SLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPT 795
++ +L +++ L ++ALL++ + IYA+IG+++F G++A D T
Sbjct: 573 GIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-------------GKIALNDTT 619
Query: 796 PCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSL 975
N NF F A+L +F+C +
Sbjct: 620 EI------------------------------------NRNNNFQTFPQAVLLLFRCATG 643
Query: 976 EGWTDVMYWV------------------NDAVGREWPWIYFVTLVILGSFFVLNLVLGVL 1101
E W D+M G + YF++ +L +F ++NL + ++
Sbjct: 644 EAWQDIMLACMPGKKCAPESEPHNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAII 703
Query: 1102 SGEF 1113
F
Sbjct: 704 MDNF 707
Score = 74.3 bits (181), Expect = 3e-11
Identities = 59/229 (25%), Positives = 98/229 (42%), Gaps = 16/229 (6%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HYGQS + N+ F LF++EM+LK+ + Y + +N FD VVI SI++
Sbjct: 478 QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLVVIGSIIDV 537
Query: 1657 VLVYFDLMKP---LGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXX 1827
+L + + + ++ R R++R+ K+
Sbjct: 538 ILSETNNAEENSRISITFFRLFRVMRLVKLLTRGEGIRTLLWTFIKSFQALPYVALLIVM 597
Query: 1828 XXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGI--- 1998
GMQVFG + + NF TF QA+L +F+ TGE W +M +
Sbjct: 598 LFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGK 657
Query: 1999 ----ESFGGVGTLGVIVC------IYYIVLFICGNYILLNVFLAIAVDN 2115
ES T G C Y+I ++ ++++N+F+AI +DN
Sbjct: 658 KCAPESEPHNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAIIMDN 706
Score = 69.3 bits (168), Expect = 1e-09
Identities = 111/582 (19%), Positives = 211/582 (36%), Gaps = 45/582 (7%)
Frame = +1
Query: 1504 DHFQTMANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYF 1671
+H ++ F +F++E+ LKM + G ++ + FN D VV S++ F +
Sbjct: 169 NHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS 228
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+ V +LR R+LR +
Sbjct: 229 AINV---VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACI 285
Query: 1852 GMQVFGGKFNFNPQQPK------------------------PRA------NFDTFVQALL 1941
G+Q+F GK K PR+ +FD + A++
Sbjct: 286 GVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMM 345
Query: 1942 TVFQILTGEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+F + T E W ++Y I+S G + V + I++I+ I + ++N+F+ +
Sbjct: 346 ALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 405
Query: 2110 DNLADADSLTNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSARPRRMSEV 2289
+ R V
Sbjct: 406 VTFQEQGE------------------------------------QEYKNCELDKNRRQCV 429
Query: 2290 PAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQA 2469
A +P+ + +I + + ++V+ VVN +YF + IL+++ LA + Q
Sbjct: 430 EYALKARPLRR----YIPKNQHQYKVW--YVVNSTYFEYLMFVLILLNTICLAMQHYGQ- 482
Query: 2470 NSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFV 2649
+ + +N + FT +FTVE+ LK+I F KG F + +N+ D LVV S+ +
Sbjct: 483 SCLFKIAMNILNMLFTGLFTVEMILKLIAFK---PKGYF-SDPWNVFDFLVVIGSIIDVI 538
Query: 2650 L------RTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFML 2811
L ++ + R +G++ ++ I + + + + L+ ML
Sbjct: 539 LSETNNAEENSRISITFFRLFRVMRLVKLLTRGEGIRTLLWTFIKSFQALPYVALLIVML 598
Query: 2812 QFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFD 2991
F++A+IG+Q+F G L ND +++ N + NF
Sbjct: 599 FFIYAVIGMQVF-GKIAL-NDTTEI----------------------------NRNNNFQ 628
Query: 2992 NVGDAMISLFVVSTFEGWPQLLYVAIDSNE-EDKGPIHNSRQ 3114
A++ LF +T E W ++ + + + HNS +
Sbjct: 629 TFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPHNSTE 670
>gi|292275|gb|AAA02501.1| L-type voltage-dependent calcium channel
Length = 2180
Score = 1028 bits (2657), Expect = 0.0
Identities = 511/830 (61%), Positives = 640/830 (76%), Gaps = 12/830 (1%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPR +SE+ P+P+AS+ FI S N FR+ C+ +VN + FTN +LF IL+SS L
Sbjct: 829 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 888
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP+Q S RN IL YFD FT++FT+EI LK+ +G HKGSFCRN FN+LD+LVV
Sbjct: 889 AAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVV 948
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
+VSL SF +++ A++ AINRAKGLKHVVQCV VA++TIGNI++VT
Sbjct: 949 SVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 1008
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG + C+D SK TEAEC+G YI Y+DG+ P+ + R W N+ F+
Sbjct: 1009 LLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFD 1068
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP+LLY +IDS+ EDKGPI+N R +++
Sbjct: 1069 FDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFM 1128
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N+ QY+VW+ V
Sbjct: 1129 MNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVN 1188
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S F+ +++ N++FTG+F E +LK++A PK
Sbjct: 1189 STYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKG 1248
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGG------------TNLISINFFRLFRVMRLV 3669
Y SD WNVFD L+V+GS ID+ + NP + ISI FFRLFRVMRLV
Sbjct: 1249 YFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLV 1308
Query: 3670 KLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNN 3849
KLLSRGEGIRTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL+D+T I+RNN
Sbjct: 1309 KLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNN 1368
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FP A+L+LFR ATGEAWQDIML+C + +C P S+ + E+ CG++FA
Sbjct: 1369 NFQTFPQAVLLLFRCATGEAWQDIMLACMPGK--KCAPESEPSNSTE-GETPCGSSFAVF 1425
Query: 4030 YFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKH 4209
YFISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+W+EYDP+AKGRIKH
Sbjct: 1426 YFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKH 1485
Query: 4210 LDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYT 4389
LDVVTLLR+I PPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFALVRT L+I T
Sbjct: 1486 LDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKT 1545
Query: 4390 EGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKK 4569
EGN+++ANE+LR+ IK+IWKRT LLD+VVPPAG +D+VTVGKFYATFLIQ+YFR+FKK
Sbjct: 1546 EGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQEYFRKFKK 1604
Query: 4570 RKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDE 4719
RKE G P+Q A++LQAGLRTLH+IGPE++RAISG+L + D+
Sbjct: 1605 RKEQGLVG-KPSQR-NALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDK 1652
Score = 708 bits (1827), Expect = 0.0
Identities = 373/668 (55%), Positives = 447/668 (66%), Gaps = 27/668 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR+ CISIVEWKPFE +IL I ANC+ALAIY P+P DS+ N+ LE +EY+F+++F
Sbjct: 82 NPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIF 141
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQ-----------G 549
T+E LK++A G +FHP+AYLRN WN+LDFIIVV+GL S IL + + G
Sbjct: 142 TVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAG 201
Query: 550 FDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELF 729
FDVKALRAFRVLRPLRLVSGVPSLQVVLN+I++AM+PLLHIALLVLFVI+IYAIIGLELF
Sbjct: 202 FDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELF 261
Query: 730 CGKLHSTCIDPA--TGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPG 903
GK+H TC + A+ DP+PC +T G +CQ + ++ G W G
Sbjct: 262 MGKMHKTCYNQEGIADVPAEDDPSPCALET-GHGRQCQ-NGTVCKPG----------WDG 309
Query: 904 PNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLN 1083
P +GITNFDNF AMLTVFQC+++EGWTDV+YW+ DA+G E PW+YFV+LVI GSFFVLN
Sbjct: 310 PKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLN 369
Query: 1084 LVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDE 1263
LVLGVLSGEFSKEREKA+ARG FQK REKQQLEEDLKGYLDWITQAEDI+P NEDE DE
Sbjct: 370 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDE 429
Query: 1264 --------PVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLE------KLNXXXXXXXX 1401
P ++T ++ A R+ + + + N
Sbjct: 430 EKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCR 489
Query: 1402 XLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSL 1581
VKS FYW SEHY Q WL Q AN + LF+ EMLLKMYSL
Sbjct: 490 AAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSL 549
Query: 1582 GFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXX 1761
G Y S FNRFDCFVV ILE +LV +M PLG+SVLR RLLRIFK+T+YW
Sbjct: 550 GLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 609
Query: 1762 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALL 1941
GMQ+FGGKFNF+ Q + R+ FD F Q+LL
Sbjct: 610 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTR-RSTFDNFPQSLL 668
Query: 1942 TVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLA 2121
TVFQILTGEDWN+VMY GI ++GG G++VCIY+I+LFICGNYILLNVFLAIAVDNLA
Sbjct: 669 TVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLA 728
Query: 2122 DADSLTNA 2145
DA+SLT+A
Sbjct: 729 DAESLTSA 736
Score = 127 bits (320), Expect = 2e-27
Identities = 100/342 (29%), Positives = 160/342 (46%), Gaps = 10/342 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V NN R C IV F LILF I + I+L
Sbjct: 829 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 888
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P Q + ++N +L + VF +FTIE LK+ A G H ++ RN +NILD +
Sbjct: 889 AAEDP--VQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLL 946
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S + +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 947 VVSVSLISFGIQSSAINV--VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIV 1004
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ-KDPTPCGTDTEGSAFKCQPSDSL 852
++ + ++A IG++LF GKL+ TC D + A+ K D E QP
Sbjct: 1005 IVTTLLQFMFACIGVQLFKGKLY-TCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRS-- 1061
Query: 853 TNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWP 1032
WE N +FDN AM+ +F + EGW +++Y D+ +
Sbjct: 1062 ------WE-----------NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKG 1104
Query: 1033 WIY---------FVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
IY F+ +I+ +FF++N+ +G + F ++ E+
Sbjct: 1105 PIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1146
Score = 95.9 bits (237), Expect = 1e-17
Identities = 64/259 (24%), Positives = 124/259 (47%), Gaps = 5/259 (1%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S F +++ ++ +NT+++A +HY + D N +F E +LK+ +L
Sbjct: 492 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 551
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD VV G ++ + + + I+ R R++R+ K+ +
Sbjct: 552 QAYFVSLFNRFDCFVVCGGILETIL--VETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 609
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + + S +++ + LL+ L I++++GMQ F GK D+ + R + F +FP ++
Sbjct: 610 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT--RRSTFDNFPQSL 667
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNF----AYPYFISF 4044
L +F+ TGE W +M D G G +F YFI
Sbjct: 668 LTVFQILTGEDWNSVMY--------------DGIMAYG------GPSFPGMLVCIYFIIL 707
Query: 4045 FMLCSFLVINLFVAVIMDN 4101
F+ +++++N+F+A+ +DN
Sbjct: 708 FICGNYILLNVFLAIAVDN 726
Score = 89.7 bits (221), Expect = 7e-16
Identities = 74/315 (23%), Positives = 131/315 (41%), Gaps = 33/315 (10%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+L+ +I N I LA+ Q Y Q +K + + +F +FT+E +LK++A F
Sbjct: 1192 FEYLMFVLILLNTICLAM-QHY-GQSCLFK-IAMNILNMLFTGLFTVEMILKLIA----F 1244
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMSI---------------QGFDVKALRAFRV 582
P Y + WN+ DF+IV+ ++ ILS+ + + R FRV
Sbjct: 1245 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRV 1304
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
+R ++L+S ++ +L +++ L ++ALL++ + IYA+IG+++F
Sbjct: 1305 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF----------- 1353
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
G++A D T N NF F
Sbjct: 1354 --GKIALNDTTEI------------------------------------NRNNNFQTFPQ 1375
Query: 943 AMLTVFQCVSLEGWTDVMYWV------------------NDAVGREWPWIYFVTLVILGS 1068
A+L +F+C + E W D+M G + YF++ +L +
Sbjct: 1376 AVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCA 1435
Query: 1069 FFVLNLVLGVLSGEF 1113
F ++NL + V+ F
Sbjct: 1436 FLIINLFVAVIMDNF 1450
Score = 89.4 bits (220), Expect = 9e-16
Identities = 89/353 (25%), Positives = 144/353 (40%), Gaps = 54/353 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE +I L I N V+LA +P S L+ +F +F EA LK++A
Sbjct: 95 KPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGL 154
Query: 3511 -LNPKNYISDRWNVFD-LLVVVGSFIDITYGKLNPGGTNLIS-------INFFRLFRVMR 3663
+P Y+ + WN+ D ++VVVG F I G N + + R FRV+R
Sbjct: 155 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLR 214
Query: 3664 LVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV--------- 3813
++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F GK+
Sbjct: 215 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEG 274
Query: 3814 -----ALDDSTSI------------------------HRNNNFHSFPAAILVLFRSATGE 3906
A DD + H NF +F A+L +F+ T E
Sbjct: 275 IADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITME 334
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVA 4086
W D++ D G + YF+S + SF V+NL +
Sbjct: 335 GWTDVLYWMQD---------------------AMGYELPWVYFVSLVIFGSFFVLNLVLG 373
Query: 4087 VIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
V+ F G + +R + + D KG +LD +T I P
Sbjct: 374 VLSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 420
Score = 89.0 bits (219), Expect = 1e-15
Identities = 82/300 (27%), Positives = 130/300 (43%), Gaps = 32/300 (10%)
Frame = +1
Query: 2257 TSARPRRMSEVP---AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCIL 2427
++ R RR P ++T P+A L L+ N R C +V F +L I
Sbjct: 49 STQRKRRQYGKPKKQGSTTATRPPRA--LLCLTLKNPIRRACISIVEWKPFEIIILLTIF 106
Query: 2428 VSSAMLAAEDPLQANSTR--NMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAF 2601
+ LA P + + N L +Y F +FTVE LKVI +GL+FH ++ RN +
Sbjct: 107 ANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 166
Query: 2602 NLLDILVVAVSLTSFVL----RTDAMSXXXXXXXXXXXXXXXA---------INRAKGLK 2742
NLLD ++V V L S +L + D + A ++ L+
Sbjct: 167 NLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQ 226
Query: 2743 HVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFF-LCNDLSKMTE-------AE 2898
V+ +I A+ + +I L+ + ++AIIG++LF G C + + + +
Sbjct: 227 VVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSP 286
Query: 2899 CRGEYIH---YEDGDPTKPVSKKRVW---SNNDFNFDNVGDAMISLFVVSTFEGWPQLLY 3060
C E H ++G KP W + NFDN AM+++F T EGW +LY
Sbjct: 287 CALETGHGRQCQNGTVCKP-----GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLY 341
Score = 70.9 bits (172), Expect = 3e-10
Identities = 57/240 (23%), Positives = 98/240 (40%), Gaps = 27/240 (11%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HYGQS + N+ F LF++EM+LK+ + Y + +N FD +VI SI++
Sbjct: 1210 QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDV 1269
Query: 1657 VL--------------VYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXX 1794
+L + + + ++ R R++R+ K+
Sbjct: 1270 ILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQ 1329
Query: 1795 XXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDW 1974
GMQVFG + + NF TF QA+L +F+ TGE W
Sbjct: 1330 ALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAW 1389
Query: 1975 NTVMYHGI-------ESFGGVGTLGVIVC------IYYIVLFICGNYILLNVFLAIAVDN 2115
+M + ES T G C Y+I ++ ++++N+F+A+ +DN
Sbjct: 1390 QDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDN 1449
Score = 41.2 bits (95), Expect = 0.29
Identities = 46/240 (19%), Positives = 87/240 (36%), Gaps = 38/240 (15%)
Frame = +1
Query: 1504 DHFQTMANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYF 1671
+H ++ F +F++E+ LKM + G ++ + FN D VV S++ F +
Sbjct: 901 NHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS 960
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+ V +LR R+LR +
Sbjct: 961 AINV---VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACI 1017
Query: 1852 GMQVFGGKFNFNPQQPK------------------------PRA------NFDTFVQALL 1941
G+Q+F GK K PR+ +FD + A++
Sbjct: 1018 GVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMM 1077
Query: 1942 TVFQILTGEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+F + T E W ++Y I+S G + V + I++I+ I + ++N+F+ +
Sbjct: 1078 ALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1137
>gi|463073|gb|AAA51899.1| L-type voltage-dependent cardiac calcium
channel alpha 1 subunit
Length = 2169
Score = 1028 bits (2657), Expect = 0.0
Identities = 510/819 (62%), Positives = 639/819 (77%), Gaps = 1/819 (0%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPR +SE+ P+P+AS+ FI S N FR+ C+ +VN + FTN +LF IL+SS L
Sbjct: 829 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 888
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP+Q S RN IL YFD FT++FT+EI LK+ +G HKGSFCRN FN+LD+LVV
Sbjct: 889 AAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVV 948
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
+VSL SF +++ A++ AINRAKGLKHVVQCV VA++TIGNI++VT
Sbjct: 949 SVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 1008
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG + C+D SK TEAEC+G YI Y+DG+ P+ + R W N+ F+
Sbjct: 1009 LLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFD 1068
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP+LLY +IDS+ EDKGPI+N R +++
Sbjct: 1069 FDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFM 1128
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N+ QY+VW+ V
Sbjct: 1129 MNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVN 1188
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S F+ +++ N++FTG+F E +LK++A PK+
Sbjct: 1189 STYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKH 1248
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGGTNL-ISINFFRLFRVMRLVKLLSRGEGIRT 3702
Y D WN FD L+VVGS +DI ++N N ISI FFRLFRVMRLVKLLSRGEGIRT
Sbjct: 1249 YFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEGIRT 1308
Query: 3703 LLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILV 3882
LLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL+D+T I+RNNNF +FP A+L+
Sbjct: 1309 LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLL 1368
Query: 3883 LFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSF 4062
LFR ATGEAWQDIML+C + +C P S+ + E+ CG++FA YFISF+MLC+F
Sbjct: 1369 LFRCATGEAWQDIMLACMPGK--KCAPESEPSNSTE-GETPCGSSFAVFYFISFYMLCAF 1425
Query: 4063 LVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKIS 4242
L+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+W+EYDP+AKGRIKHLDVVTLLR+I
Sbjct: 1426 LIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQ 1485
Query: 4243 PPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNIDEANEQL 4422
PPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFALVRT L+I TEGN+++ANE+L
Sbjct: 1486 PPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEEL 1545
Query: 4423 RSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEMEAKGVLP 4602
R+ IK+IWKRT LLD+VVPPAG +D+VTVGKFYATFLIQ+YFR+FKKRKE G P
Sbjct: 1546 RAIIKKIWKRTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQEYFRKFKKRKEQGLVG-KP 1603
Query: 4603 AQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDE 4719
+Q A++LQAGLRTLH+IGPE++RAISG+L + D+
Sbjct: 1604 SQR-NALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDK 1641
Score = 708 bits (1827), Expect = 0.0
Identities = 373/668 (55%), Positives = 447/668 (66%), Gaps = 27/668 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR+ CISIVEWKPFE +IL I ANC+ALAIY P+P DS+ N+ LE +EY+F+++F
Sbjct: 82 NPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIF 141
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQ-----------G 549
T+E LK++A G +FHP+AYLRN WN+LDFIIVV+GL S IL + + G
Sbjct: 142 TVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAG 201
Query: 550 FDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELF 729
FDVKALRAFRVLRPLRLVSGVPSLQVVLN+I++AM+PLLHIALLVLFVI+IYAIIGLELF
Sbjct: 202 FDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELF 261
Query: 730 CGKLHSTCIDPA--TGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPG 903
GK+H TC + A+ DP+PC +T G +CQ + ++ G W G
Sbjct: 262 MGKMHKTCYNQEGIADVPAEDDPSPCALET-GHGRQCQ-NGTVCKPG----------WDG 309
Query: 904 PNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLN 1083
P +GITNFDNF AMLTVFQC+++EGWTDV+YW+ DA+G E PW+YFV+LVI GSFFVLN
Sbjct: 310 PKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLN 369
Query: 1084 LVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDE 1263
LVLGVLSGEFSKEREKA+ARG FQK REKQQLEEDLKGYLDWITQAEDI+P NEDE DE
Sbjct: 370 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDE 429
Query: 1264 --------PVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLE------KLNXXXXXXXX 1401
P ++T ++ A R+ + + + N
Sbjct: 430 EKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCR 489
Query: 1402 XLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSL 1581
VKS FYW SEHY Q WL Q AN + LF+ EMLLKMYSL
Sbjct: 490 AAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSL 549
Query: 1582 GFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXX 1761
G Y S FNRFDCFVV ILE +LV +M PLG+SVLR RLLRIFK+T+YW
Sbjct: 550 GLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 609
Query: 1762 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALL 1941
GMQ+FGGKFNF+ Q + R+ FD F Q+LL
Sbjct: 610 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTR-RSTFDNFPQSLL 668
Query: 1942 TVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLA 2121
TVFQILTGEDWN+VMY GI ++GG G++VCIY+I+LFICGNYILLNVFLAIAVDNLA
Sbjct: 669 TVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLA 728
Query: 2122 DADSLTNA 2145
DA+SLT+A
Sbjct: 729 DAESLTSA 736
Score = 127 bits (320), Expect = 2e-27
Identities = 100/342 (29%), Positives = 160/342 (46%), Gaps = 10/342 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V NN R C IV F LILF I + I+L
Sbjct: 829 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 888
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P Q + ++N +L + VF +FTIE LK+ A G H ++ RN +NILD +
Sbjct: 889 AAEDP--VQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLL 946
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S + +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 947 VVSVSLISFGIQSSAINV--VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIV 1004
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ-KDPTPCGTDTEGSAFKCQPSDSL 852
++ + ++A IG++LF GKL+ TC D + A+ K D E QP
Sbjct: 1005 IVTTLLQFMFACIGVQLFKGKLY-TCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRS-- 1061
Query: 853 TNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWP 1032
WE N +FDN AM+ +F + EGW +++Y D+ +
Sbjct: 1062 ------WE-----------NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKG 1104
Query: 1033 WIY---------FVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
IY F+ +I+ +FF++N+ +G + F ++ E+
Sbjct: 1105 PIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1146
Score = 95.9 bits (237), Expect = 1e-17
Identities = 64/259 (24%), Positives = 124/259 (47%), Gaps = 5/259 (1%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S F +++ ++ +NT+++A +HY + D N +F E +LK+ +L
Sbjct: 492 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 551
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD VV G ++ + + + I+ R R++R+ K+ +
Sbjct: 552 QAYFVSLFNRFDCFVVCGGILETIL--VETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 609
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + + S +++ + LL+ L I++++GMQ F GK D+ + R + F +FP ++
Sbjct: 610 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT--RRSTFDNFPQSL 667
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNF----AYPYFISF 4044
L +F+ TGE W +M D G G +F YFI
Sbjct: 668 LTVFQILTGEDWNSVMY--------------DGIMAYG------GPSFPGMLVCIYFIIL 707
Query: 4045 FMLCSFLVINLFVAVIMDN 4101
F+ +++++N+F+A+ +DN
Sbjct: 708 FICGNYILLNVFLAIAVDN 726
Score = 89.4 bits (220), Expect = 9e-16
Identities = 89/353 (25%), Positives = 144/353 (40%), Gaps = 54/353 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE +I L I N V+LA +P S L+ +F +F EA LK++A
Sbjct: 95 KPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGL 154
Query: 3511 -LNPKNYISDRWNVFD-LLVVVGSFIDITYGKLNPGGTNLIS-------INFFRLFRVMR 3663
+P Y+ + WN+ D ++VVVG F I G N + + R FRV+R
Sbjct: 155 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLR 214
Query: 3664 LVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV--------- 3813
++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F GK+
Sbjct: 215 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEG 274
Query: 3814 -----ALDDSTSI------------------------HRNNNFHSFPAAILVLFRSATGE 3906
A DD + H NF +F A+L +F+ T E
Sbjct: 275 IADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITME 334
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVA 4086
W D++ D G + YF+S + SF V+NL +
Sbjct: 335 GWTDVLYWMQD---------------------AMGYELPWVYFVSLVIFGSFFVLNLVLG 373
Query: 4087 VIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
V+ F G + +R + + D KG +LD +T I P
Sbjct: 374 VLSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 420
Score = 89.0 bits (219), Expect = 1e-15
Identities = 82/300 (27%), Positives = 130/300 (43%), Gaps = 32/300 (10%)
Frame = +1
Query: 2257 TSARPRRMSEVP---AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCIL 2427
++ R RR P ++T P+A L L+ N R C +V F +L I
Sbjct: 49 STQRKRRQYGKPKKQGSTTATRPPRA--LLCLTLKNPIRRACISIVEWKPFEIIILLTIF 106
Query: 2428 VSSAMLAAEDPLQANSTR--NMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAF 2601
+ LA P + + N L +Y F +FTVE LKVI +GL+FH ++ RN +
Sbjct: 107 ANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 166
Query: 2602 NLLDILVVAVSLTSFVL----RTDAMSXXXXXXXXXXXXXXXA---------INRAKGLK 2742
NLLD ++V V L S +L + D + A ++ L+
Sbjct: 167 NLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQ 226
Query: 2743 HVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFF-LCNDLSKMTE-------AE 2898
V+ +I A+ + +I L+ + ++AIIG++LF G C + + + +
Sbjct: 227 VVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSP 286
Query: 2899 CRGEYIH---YEDGDPTKPVSKKRVW---SNNDFNFDNVGDAMISLFVVSTFEGWPQLLY 3060
C E H ++G KP W + NFDN AM+++F T EGW +LY
Sbjct: 287 CALETGHGRQCQNGTVCKP-----GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLY 341
Score = 87.0 bits (214), Expect = 5e-15
Identities = 73/304 (24%), Positives = 130/304 (42%), Gaps = 22/304 (7%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+L+ +I N I LA+ Q Y Q +K + + +F +FT+E +LK++A F
Sbjct: 1192 FEYLMFVLILLNTICLAM-QHY-GQSCLFK-IAMNILNMLFTGLFTVEMILKLIA----F 1244
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMSI----QGFDVKALRAFRVLRPLRLVSGVP 615
P Y +AWN D +IVV +V +++++ + R FRV+R ++L+S
Sbjct: 1245 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGE 1304
Query: 616 SLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPT 795
++ +L +++ L ++ALL++ + IYA+IG+++F G++A D T
Sbjct: 1305 GIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-------------GKIALNDTT 1351
Query: 796 PCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSL 975
N NF F A+L +F+C +
Sbjct: 1352 EI------------------------------------NRNNNFQTFPQAVLLLFRCATG 1375
Query: 976 EGWTDVMYWV------------------NDAVGREWPWIYFVTLVILGSFFVLNLVLGVL 1101
E W D+M G + YF++ +L +F ++NL + V+
Sbjct: 1376 EAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVI 1435
Query: 1102 SGEF 1113
F
Sbjct: 1436 MDNF 1439
Score = 74.3 bits (181), Expect = 3e-11
Identities = 55/229 (24%), Positives = 96/229 (41%), Gaps = 16/229 (6%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HYGQS + N+ F LF++EM+LK+ + Y +N FD +V+ SI++
Sbjct: 1210 QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDI 1269
Query: 1657 VLVYFDLMKP---LGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXX 1827
+ + + + ++ R R++R+ K+
Sbjct: 1270 AITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVM 1329
Query: 1828 XXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGI--- 1998
GMQVFG + + NF TF QA+L +F+ TGE W +M +
Sbjct: 1330 LFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGK 1389
Query: 1999 ----ESFGGVGTLGVIVC------IYYIVLFICGNYILLNVFLAIAVDN 2115
ES T G C Y+I ++ ++++N+F+A+ +DN
Sbjct: 1390 KCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDN 1438
Score = 41.2 bits (95), Expect = 0.29
Identities = 46/240 (19%), Positives = 87/240 (36%), Gaps = 38/240 (15%)
Frame = +1
Query: 1504 DHFQTMANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYF 1671
+H ++ F +F++E+ LKM + G ++ + FN D VV S++ F +
Sbjct: 901 NHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS 960
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+ V +LR R+LR +
Sbjct: 961 AINV---VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACI 1017
Query: 1852 GMQVFGGKFNFNPQQPK------------------------PRA------NFDTFVQALL 1941
G+Q+F GK K PR+ +FD + A++
Sbjct: 1018 GVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMM 1077
Query: 1942 TVFQILTGEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+F + T E W ++Y I+S G + V + I++I+ I + ++N+F+ +
Sbjct: 1078 ALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1137
>gi|509048|emb|CAA84347.1| voltage-dependent L-type Ca channel alpha 1
subunit [Homo sapiens]
Length = 2138
Score = 1028 bits (2657), Expect = 0.0
Identities = 511/830 (61%), Positives = 640/830 (76%), Gaps = 12/830 (1%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPR +SE+ P+P+AS+ FI S N FR+ C+ +VN + FTN +LF IL+SS L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP+Q S RN IL YFD FT++FT+EI LK+ +G HKGSFCRN FN+LD+LVV
Sbjct: 918 AAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVV 977
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
+VSL SF +++ A++ AINRAKGLKHVVQCV VA++TIGNI++VT
Sbjct: 978 SVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 1037
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG + C+D SK TEAEC+G YI Y+DG+ P+ + R W N+ F+
Sbjct: 1038 LLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFD 1097
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP+LLY +IDS+ EDKGPI+N R +++
Sbjct: 1098 FDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFM 1157
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N+ QY+VW+ V
Sbjct: 1158 MNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVN 1217
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S F+ +++ N++FTG+F E +LK++A PK
Sbjct: 1218 STYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKG 1277
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGG------------TNLISINFFRLFRVMRLV 3669
Y SD WNVFD L+V+GS ID+ + NP + ISI FFRLFRVMRLV
Sbjct: 1278 YFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLV 1337
Query: 3670 KLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNN 3849
KLLSRGEGIRTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL+D+T I+RNN
Sbjct: 1338 KLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNN 1397
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FP A+L+LFR ATGEAWQDIML+C + +C P S+ + E+ CG++FA
Sbjct: 1398 NFQTFPQAVLLLFRCATGEAWQDIMLACMPGK--KCAPESEPSNSTE-GETPCGSSFAVF 1454
Query: 4030 YFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKH 4209
YFISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+W+EYDP+AKGRIKH
Sbjct: 1455 YFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKH 1514
Query: 4210 LDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYT 4389
LDVVTLLR+I PPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFALVRT L+I T
Sbjct: 1515 LDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKT 1574
Query: 4390 EGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKK 4569
EGN+++ANE+LR+ IK+IWKRT LLD+VVPPAG +D+VTVGKFYATFLIQ+YFR+FKK
Sbjct: 1575 EGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQEYFRKFKK 1633
Query: 4570 RKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDE 4719
RKE G P+Q A++LQAGLRTLH+IGPE++RAISG+L + D+
Sbjct: 1634 RKEQGLVG-KPSQR-NALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDK 1681
Score = 722 bits (1863), Expect = 0.0
Identities = 383/698 (54%), Positives = 459/698 (64%), Gaps = 28/698 (4%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXX-XXXNNPIRKLCISIVEWKPFEFLILFMICANCIA 312
+KR KP +Q + NPIR+ CISIVEWKPFE +IL I ANC+A
Sbjct: 81 RKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVA 140
Query: 313 LAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDF 492
LAIY P+P DS+ N+ LE +EY+F+++FT+E LK++A G +FHP+AYLRN WN+LDF
Sbjct: 141 LAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDF 200
Query: 493 IIVVIGLVSTILSKMSIQ-----------GFDVKALRAFRVLRPLRLVSGVPSLQVVLNA 639
IIVV+GL S IL + + GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+
Sbjct: 201 IIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNS 260
Query: 640 ILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPA--TGQLAQKDPTPCGTDT 813
I++AM+PLLHIALLVLFVI+IYAIIGLELF GK+H TC + A+ DP+PC +T
Sbjct: 261 IIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALET 320
Query: 814 EGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDV 993
G +CQ + ++ G W GP +GITNFDNF AMLTVFQC+++EGWTDV
Sbjct: 321 -GHGRQCQ-NGTVCKPG----------WDGPKHGITNFDNFAFAMLTVFQCITMEGWTDV 368
Query: 994 MYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQ 1173
+YWVNDAVGR+WPWIYFVTL+I+GSFFVLNLVLGVLSGEFSKEREKA+ARG FQK REKQ
Sbjct: 369 LYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 428
Query: 1174 QLEEDLKGYLDWITQAEDIEPVNEDEQEDE--------PVAQTXXXXXXXXXXXXXXXXX 1329
QLEEDLKGYLDWITQAEDI+P NEDE DE P ++T
Sbjct: 429 QLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGEN 488
Query: 1330 XPSKWAARMKRLE------KLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQ 1491
++ A R+ + + + N VKS FYW SEHY Q
Sbjct: 489 CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQ 548
Query: 1492 SEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYF 1671
WL Q AN + LF+ EMLLKMYSLG Y S FNRFDCFVV ILE +LV
Sbjct: 549 PNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+M PLG+SVLR RLLRIFK+T+YW
Sbjct: 609 KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668
Query: 1852 GMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGV 2031
GMQ+FGGKFNF+ Q + R+ FD F Q+LLTVFQILTGEDWN+VMY GI ++GG G+
Sbjct: 669 GMQLFGGKFNFDEMQTR-RSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGM 727
Query: 2032 IVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNA 2145
+VCIY+I+LFICGNYILLNVFLAIAVDNLADA+SLT+A
Sbjct: 728 LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSA 765
Score = 127 bits (320), Expect = 2e-27
Identities = 100/342 (29%), Positives = 160/342 (46%), Gaps = 10/342 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V NN R C IV F LILF I + I+L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P Q + ++N +L + VF +FTIE LK+ A G H ++ RN +NILD +
Sbjct: 918 AAEDP--VQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLL 975
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S + +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 976 VVSVSLISFGIQSSAINV--VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIV 1033
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ-KDPTPCGTDTEGSAFKCQPSDSL 852
++ + ++A IG++LF GKL+ TC D + A+ K D E QP
Sbjct: 1034 IVTTLLQFMFACIGVQLFKGKLY-TCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRS-- 1090
Query: 853 TNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWP 1032
WE N +FDN AM+ +F + EGW +++Y D+ +
Sbjct: 1091 ------WE-----------NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKG 1133
Query: 1033 WIY---------FVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
IY F+ +I+ +FF++N+ +G + F ++ E+
Sbjct: 1134 PIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1175
Score = 95.9 bits (237), Expect = 1e-17
Identities = 64/259 (24%), Positives = 124/259 (47%), Gaps = 5/259 (1%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S F +++ ++ +NT+++A +HY + D N +F E +LK+ +L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD VV G ++ + + + I+ R R++R+ K+ +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL--VETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + + S +++ + LL+ L I++++GMQ F GK D+ + R + F +FP ++
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT--RRSTFDNFPQSL 696
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNF----AYPYFISF 4044
L +F+ TGE W +M D G G +F YFI
Sbjct: 697 LTVFQILTGEDWNSVMY--------------DGIMAYG------GPSFPGMLVCIYFIIL 736
Query: 4045 FMLCSFLVINLFVAVIMDN 4101
F+ +++++N+F+A+ +DN
Sbjct: 737 FICGNYILLNVFLAIAVDN 755
Score = 90.9 bits (224), Expect = 3e-16
Identities = 88/353 (24%), Positives = 148/353 (40%), Gaps = 54/353 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE +I L I N V+LA +P S L+ +F +F EA LK++A
Sbjct: 124 KPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGL 183
Query: 3511 -LNPKNYISDRWNVFD-LLVVVGSFIDITYGKLNPGGTNLIS-------INFFRLFRVMR 3663
+P Y+ + WN+ D ++VVVG F I G N + + R FRV+R
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLR 243
Query: 3664 LVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV--------- 3813
++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F GK+
Sbjct: 244 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEG 303
Query: 3814 -----ALDDSTSI------------------------HRNNNFHSFPAAILVLFRSATGE 3906
A DD + H NF +F A+L +F+ T E
Sbjct: 304 IADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITME 363
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVA 4086
W D++ +D G ++ + YF++ ++ SF V+NL +
Sbjct: 364 GWTDVLYWVND---------------------AVGRDWPWIYFVTLIIIGSFFVLNLVLG 402
Query: 4087 VIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
V+ F G + +R + + D KG +LD +T I P
Sbjct: 403 VLSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 449
Score = 89.7 bits (221), Expect = 7e-16
Identities = 74/315 (23%), Positives = 131/315 (41%), Gaps = 33/315 (10%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+L+ +I N I LA+ Q Y Q +K + + +F +FT+E +LK++A F
Sbjct: 1221 FEYLMFVLILLNTICLAM-QHY-GQSCLFK-IAMNILNMLFTGLFTVEMILKLIA----F 1273
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMSI---------------QGFDVKALRAFRV 582
P Y + WN+ DF+IV+ ++ ILS+ + + R FRV
Sbjct: 1274 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRV 1333
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
+R ++L+S ++ +L +++ L ++ALL++ + IYA+IG+++F
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF----------- 1382
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
G++A D T N NF F
Sbjct: 1383 --GKIALNDTTEI------------------------------------NRNNNFQTFPQ 1404
Query: 943 AMLTVFQCVSLEGWTDVMYWV------------------NDAVGREWPWIYFVTLVILGS 1068
A+L +F+C + E W D+M G + YF++ +L +
Sbjct: 1405 AVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCA 1464
Query: 1069 FFVLNLVLGVLSGEF 1113
F ++NL + V+ F
Sbjct: 1465 FLIINLFVAVIMDNF 1479
Score = 89.0 bits (219), Expect = 1e-15
Identities = 77/282 (27%), Positives = 122/282 (42%), Gaps = 29/282 (10%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR--NMILNYF 2502
+L L+ N R C +V F +L I + LA P + + N L
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL----RTDAMS 2670
+Y F +FTVE LKVI +GL+FH ++ RN +NLLD ++V V L S +L + D +
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 2671 XXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
A ++ L+ V+ +I A+ + +I L+ + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 2824 AIIGVQLFKGTFF-LCNDLSKMTE-------AECRGEYIH---YEDGDPTKPVSKKRVW- 2967
AIIG++LF G C + + + + C E H ++G KP W
Sbjct: 283 AIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKP-----GWD 337
Query: 2968 --SNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEED 3087
+ NFDN AM+++F T EGW +LY D+ D
Sbjct: 338 GPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRD 379
Score = 70.9 bits (172), Expect = 3e-10
Identities = 57/240 (23%), Positives = 98/240 (40%), Gaps = 27/240 (11%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HYGQS + N+ F LF++EM+LK+ + Y + +N FD +VI SI++
Sbjct: 1239 QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDV 1298
Query: 1657 VL--------------VYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXX 1794
+L + + + ++ R R++R+ K+
Sbjct: 1299 ILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQ 1358
Query: 1795 XXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDW 1974
GMQVFG + + NF TF QA+L +F+ TGE W
Sbjct: 1359 ALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAW 1418
Query: 1975 NTVMYHGI-------ESFGGVGTLGVIVC------IYYIVLFICGNYILLNVFLAIAVDN 2115
+M + ES T G C Y+I ++ ++++N+F+A+ +DN
Sbjct: 1419 QDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDN 1478
Score = 41.2 bits (95), Expect = 0.29
Identities = 46/240 (19%), Positives = 87/240 (36%), Gaps = 38/240 (15%)
Frame = +1
Query: 1504 DHFQTMANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYF 1671
+H ++ F +F++E+ LKM + G ++ + FN D VV S++ F +
Sbjct: 930 NHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS 989
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+ V +LR R+LR +
Sbjct: 990 AINV---VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACI 1046
Query: 1852 GMQVFGGKFNFNPQQPK------------------------PRA------NFDTFVQALL 1941
G+Q+F GK K PR+ +FD + A++
Sbjct: 1047 GVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMM 1106
Query: 1942 TVFQILTGEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+F + T E W ++Y I+S G + V + I++I+ I + ++N+F+ +
Sbjct: 1107 ALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1166
>gi|463079|gb|AAA51900.1| cardiac L-type voltage-dependent calcium
channel a1 subunit [Homo sapiens]
Length = 2144
Score = 1028 bits (2657), Expect = 0.0
Identities = 511/830 (61%), Positives = 640/830 (76%), Gaps = 12/830 (1%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPR +SE+ P+P+AS+ FI S N FR+ C+ +VN + FTN +LF IL+SS L
Sbjct: 829 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 888
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP+Q S RN IL YFD FT++FT+EI LK+ +G HKGSFCRN FN+LD+LVV
Sbjct: 889 AAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVV 948
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
+VSL SF +++ A++ AINRAKGLKHVVQCV VA++TIGNI++VT
Sbjct: 949 SVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 1008
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG + C+D SK TEAEC+G YI Y+DG+ P+ + R W N+ F+
Sbjct: 1009 LLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFD 1068
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP+LLY +IDS+ EDKGPI+N R +++
Sbjct: 1069 FDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFM 1128
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N+ QY+VW+ V
Sbjct: 1129 MNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVN 1188
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S F+ +++ N++FTG+F E +LK++A PK
Sbjct: 1189 STYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKG 1248
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGG------------TNLISINFFRLFRVMRLV 3669
Y SD WNVFD L+V+GS ID+ + NP + ISI FFRLFRVMRLV
Sbjct: 1249 YFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLV 1308
Query: 3670 KLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNN 3849
KLLSRGEGIRTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL+D+T I+RNN
Sbjct: 1309 KLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNN 1368
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FP A+L+LFR ATGEAWQDIML+C + +C P S+ + E+ CG++FA
Sbjct: 1369 NFQTFPQAVLLLFRCATGEAWQDIMLACMPGK--KCAPESEPSNSTE-GETPCGSSFAVF 1425
Query: 4030 YFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKH 4209
YFISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+W+EYDP+AKGRIKH
Sbjct: 1426 YFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKH 1485
Query: 4210 LDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYT 4389
LDVVTLLR+I PPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFALVRT L+I T
Sbjct: 1486 LDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKT 1545
Query: 4390 EGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKK 4569
EGN+++ANE+LR+ IK+IWKRT LLD+VVPPAG +D+VTVGKFYATFLIQ+YFR+FKK
Sbjct: 1546 EGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQEYFRKFKK 1604
Query: 4570 RKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDE 4719
RKE G P+Q A++LQAGLRTLH+IGPE++RAISG+L + D+
Sbjct: 1605 RKEQGLVG-KPSQR-NALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDK 1652
Score = 708 bits (1827), Expect = 0.0
Identities = 373/668 (55%), Positives = 447/668 (66%), Gaps = 27/668 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR+ CISIVEWKPFE +IL I ANC+ALAIY P+P DS+ N+ LE +EY+F+++F
Sbjct: 82 NPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIF 141
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQ-----------G 549
T+E LK++A G +FHP+AYLRN WN+LDFIIVV+GL S IL + + G
Sbjct: 142 TVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAG 201
Query: 550 FDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELF 729
FDVKALRAFRVLRPLRLVSGVPSLQVVLN+I++AM+PLLHIALLVLFVI+IYAIIGLELF
Sbjct: 202 FDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELF 261
Query: 730 CGKLHSTCIDPA--TGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPG 903
GK+H TC + A+ DP+PC +T G +CQ + ++ G W G
Sbjct: 262 MGKMHKTCYNQEGIADVPAEDDPSPCALET-GHGRQCQ-NGTVCKPG----------WDG 309
Query: 904 PNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLN 1083
P +GITNFDNF AMLTVFQC+++EGWTDV+YW+ DA+G E PW+YFV+LVI GSFFVLN
Sbjct: 310 PKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLN 369
Query: 1084 LVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDE 1263
LVLGVLSGEFSKEREKA+ARG FQK REKQQLEEDLKGYLDWITQAEDI+P NEDE DE
Sbjct: 370 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDE 429
Query: 1264 --------PVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLE------KLNXXXXXXXX 1401
P ++T ++ A R+ + + + N
Sbjct: 430 EKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCR 489
Query: 1402 XLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSL 1581
VKS FYW SEHY Q WL Q AN + LF+ EMLLKMYSL
Sbjct: 490 AAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSL 549
Query: 1582 GFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXX 1761
G Y S FNRFDCFVV ILE +LV +M PLG+SVLR RLLRIFK+T+YW
Sbjct: 550 GLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 609
Query: 1762 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALL 1941
GMQ+FGGKFNF+ Q + R+ FD F Q+LL
Sbjct: 610 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTR-RSTFDNFPQSLL 668
Query: 1942 TVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLA 2121
TVFQILTGEDWN+VMY GI ++GG G++VCIY+I+LFICGNYILLNVFLAIAVDNLA
Sbjct: 669 TVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLA 728
Query: 2122 DADSLTNA 2145
DA+SLT+A
Sbjct: 729 DAESLTSA 736
Score = 127 bits (320), Expect = 2e-27
Identities = 100/342 (29%), Positives = 160/342 (46%), Gaps = 10/342 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V NN R C IV F LILF I + I+L
Sbjct: 829 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 888
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P Q + ++N +L + VF +FTIE LK+ A G H ++ RN +NILD +
Sbjct: 889 AAEDP--VQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLL 946
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S + +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 947 VVSVSLISFGIQSSAINV--VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIV 1004
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ-KDPTPCGTDTEGSAFKCQPSDSL 852
++ + ++A IG++LF GKL+ TC D + A+ K D E QP
Sbjct: 1005 IVTTLLQFMFACIGVQLFKGKLY-TCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRS-- 1061
Query: 853 TNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWP 1032
WE N +FDN AM+ +F + EGW +++Y D+ +
Sbjct: 1062 ------WE-----------NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKG 1104
Query: 1033 WIY---------FVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
IY F+ +I+ +FF++N+ +G + F ++ E+
Sbjct: 1105 PIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1146
Score = 95.9 bits (237), Expect = 1e-17
Identities = 64/259 (24%), Positives = 124/259 (47%), Gaps = 5/259 (1%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S F +++ ++ +NT+++A +HY + D N +F E +LK+ +L
Sbjct: 492 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 551
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD VV G ++ + + + I+ R R++R+ K+ +
Sbjct: 552 QAYFVSLFNRFDCFVVCGGILETIL--VETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 609
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + + S +++ + LL+ L I++++GMQ F GK D+ + R + F +FP ++
Sbjct: 610 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT--RRSTFDNFPQSL 667
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNF----AYPYFISF 4044
L +F+ TGE W +M D G G +F YFI
Sbjct: 668 LTVFQILTGEDWNSVMY--------------DGIMAYG------GPSFPGMLVCIYFIIL 707
Query: 4045 FMLCSFLVINLFVAVIMDN 4101
F+ +++++N+F+A+ +DN
Sbjct: 708 FICGNYILLNVFLAIAVDN 726
Score = 89.7 bits (221), Expect = 7e-16
Identities = 74/315 (23%), Positives = 131/315 (41%), Gaps = 33/315 (10%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+L+ +I N I LA+ Q Y Q +K + + +F +FT+E +LK++A F
Sbjct: 1192 FEYLMFVLILLNTICLAM-QHY-GQSCLFK-IAMNILNMLFTGLFTVEMILKLIA----F 1244
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMSI---------------QGFDVKALRAFRV 582
P Y + WN+ DF+IV+ ++ ILS+ + + R FRV
Sbjct: 1245 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRV 1304
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
+R ++L+S ++ +L +++ L ++ALL++ + IYA+IG+++F
Sbjct: 1305 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF----------- 1353
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
G++A D T N NF F
Sbjct: 1354 --GKIALNDTTEI------------------------------------NRNNNFQTFPQ 1375
Query: 943 AMLTVFQCVSLEGWTDVMYWV------------------NDAVGREWPWIYFVTLVILGS 1068
A+L +F+C + E W D+M G + YF++ +L +
Sbjct: 1376 AVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCA 1435
Query: 1069 FFVLNLVLGVLSGEF 1113
F ++NL + V+ F
Sbjct: 1436 FLIINLFVAVIMDNF 1450
Score = 89.4 bits (220), Expect = 9e-16
Identities = 89/353 (25%), Positives = 144/353 (40%), Gaps = 54/353 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE +I L I N V+LA +P S L+ +F +F EA LK++A
Sbjct: 95 KPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGL 154
Query: 3511 -LNPKNYISDRWNVFD-LLVVVGSFIDITYGKLNPGGTNLIS-------INFFRLFRVMR 3663
+P Y+ + WN+ D ++VVVG F I G N + + R FRV+R
Sbjct: 155 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLR 214
Query: 3664 LVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV--------- 3813
++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F GK+
Sbjct: 215 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEG 274
Query: 3814 -----ALDDSTSI------------------------HRNNNFHSFPAAILVLFRSATGE 3906
A DD + H NF +F A+L +F+ T E
Sbjct: 275 IADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITME 334
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVA 4086
W D++ D G + YF+S + SF V+NL +
Sbjct: 335 GWTDVLYWMQD---------------------AMGYELPWVYFVSLVIFGSFFVLNLVLG 373
Query: 4087 VIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
V+ F G + +R + + D KG +LD +T I P
Sbjct: 374 VLSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 420
Score = 89.0 bits (219), Expect = 1e-15
Identities = 82/300 (27%), Positives = 130/300 (43%), Gaps = 32/300 (10%)
Frame = +1
Query: 2257 TSARPRRMSEVP---AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCIL 2427
++ R RR P ++T P+A L L+ N R C +V F +L I
Sbjct: 49 STQRKRRQYGKPKKQGSTTATRPPRA--LLCLTLKNPIRRACISIVEWKPFEIIILLTIF 106
Query: 2428 VSSAMLAAEDPLQANSTR--NMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAF 2601
+ LA P + + N L +Y F +FTVE LKVI +GL+FH ++ RN +
Sbjct: 107 ANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 166
Query: 2602 NLLDILVVAVSLTSFVL----RTDAMSXXXXXXXXXXXXXXXA---------INRAKGLK 2742
NLLD ++V V L S +L + D + A ++ L+
Sbjct: 167 NLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQ 226
Query: 2743 HVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFF-LCNDLSKMTE-------AE 2898
V+ +I A+ + +I L+ + ++AIIG++LF G C + + + +
Sbjct: 227 VVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSP 286
Query: 2899 CRGEYIH---YEDGDPTKPVSKKRVW---SNNDFNFDNVGDAMISLFVVSTFEGWPQLLY 3060
C E H ++G KP W + NFDN AM+++F T EGW +LY
Sbjct: 287 CALETGHGRQCQNGTVCKP-----GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLY 341
Score = 70.9 bits (172), Expect = 3e-10
Identities = 57/240 (23%), Positives = 98/240 (40%), Gaps = 27/240 (11%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HYGQS + N+ F LF++EM+LK+ + Y + +N FD +VI SI++
Sbjct: 1210 QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDV 1269
Query: 1657 VL--------------VYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXX 1794
+L + + + ++ R R++R+ K+
Sbjct: 1270 ILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQ 1329
Query: 1795 XXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDW 1974
GMQVFG + + NF TF QA+L +F+ TGE W
Sbjct: 1330 ALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAW 1389
Query: 1975 NTVMYHGI-------ESFGGVGTLGVIVC------IYYIVLFICGNYILLNVFLAIAVDN 2115
+M + ES T G C Y+I ++ ++++N+F+A+ +DN
Sbjct: 1390 QDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDN 1449
Score = 41.2 bits (95), Expect = 0.29
Identities = 46/240 (19%), Positives = 87/240 (36%), Gaps = 38/240 (15%)
Frame = +1
Query: 1504 DHFQTMANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYF 1671
+H ++ F +F++E+ LKM + G ++ + FN D VV S++ F +
Sbjct: 901 NHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS 960
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+ V +LR R+LR +
Sbjct: 961 AINV---VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACI 1017
Query: 1852 GMQVFGGKFNFNPQQPK------------------------PRA------NFDTFVQALL 1941
G+Q+F GK K PR+ +FD + A++
Sbjct: 1018 GVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMM 1077
Query: 1942 TVFQILTGEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+F + T E W ++Y I+S G + V + I++I+ I + ++N+F+ +
Sbjct: 1078 ALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1137
>gi|463082|gb|AAA51901.1| calcium channel L-type alpha 1 subunit [Homo
sapiens]
Length = 2109
Score = 1028 bits (2657), Expect = 0.0
Identities = 511/830 (61%), Positives = 640/830 (76%), Gaps = 12/830 (1%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPR +SE+ P+P+AS+ FI S N FR+ C+ +VN + FTN +LF IL+SS L
Sbjct: 829 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 888
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP+Q S RN IL YFD FT++FT+EI LK+ +G HKGSFCRN FN+LD+LVV
Sbjct: 889 AAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVV 948
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
+VSL SF +++ A++ AINRAKGLKHVVQCV VA++TIGNI++VT
Sbjct: 949 SVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 1008
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG + C+D SK TEAEC+G YI Y+DG+ P+ + R W N+ F+
Sbjct: 1009 LLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFD 1068
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP+LLY +IDS+ EDKGPI+N R +++
Sbjct: 1069 FDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFM 1128
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N+ QY+VW+ V
Sbjct: 1129 MNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVN 1188
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S F+ +++ N++FTG+F E +LK++A PK
Sbjct: 1189 STYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKG 1248
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGG------------TNLISINFFRLFRVMRLV 3669
Y SD WNVFD L+V+GS ID+ + NP + ISI FFRLFRVMRLV
Sbjct: 1249 YFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLV 1308
Query: 3670 KLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNN 3849
KLLSRGEGIRTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL+D+T I+RNN
Sbjct: 1309 KLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNN 1368
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FP A+L+LFR ATGEAWQDIML+C + +C P S+ + E+ CG++FA
Sbjct: 1369 NFQTFPQAVLLLFRCATGEAWQDIMLACMPGK--KCAPESEPSNSTE-GETPCGSSFAVF 1425
Query: 4030 YFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKH 4209
YFISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+W+EYDP+AKGRIKH
Sbjct: 1426 YFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKH 1485
Query: 4210 LDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYT 4389
LDVVTLLR+I PPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFALVRT L+I T
Sbjct: 1486 LDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKT 1545
Query: 4390 EGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKK 4569
EGN+++ANE+LR+ IK+IWKRT LLD+VVPPAG +D+VTVGKFYATFLIQ+YFR+FKK
Sbjct: 1546 EGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQEYFRKFKK 1604
Query: 4570 RKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDE 4719
RKE G P+Q A++LQAGLRTLH+IGPE++RAISG+L + D+
Sbjct: 1605 RKEQGLVG-KPSQR-NALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDK 1652
Score = 708 bits (1827), Expect = 0.0
Identities = 373/668 (55%), Positives = 447/668 (66%), Gaps = 27/668 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR+ CISIVEWKPFE +IL I ANC+ALAIY P+P DS+ N+ LE +EY+F+++F
Sbjct: 82 NPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIF 141
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQ-----------G 549
T+E LK++A G +FHP+AYLRN WN+LDFIIVV+GL S IL + + G
Sbjct: 142 TVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAG 201
Query: 550 FDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELF 729
FDVKALRAFRVLRPLRLVSGVPSLQVVLN+I++AM+PLLHIALLVLFVI+IYAIIGLELF
Sbjct: 202 FDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELF 261
Query: 730 CGKLHSTCIDPA--TGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPG 903
GK+H TC + A+ DP+PC +T G +CQ + ++ G W G
Sbjct: 262 MGKMHKTCYNQEGIADVPAEDDPSPCALET-GHGRQCQ-NGTVCKPG----------WDG 309
Query: 904 PNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLN 1083
P +GITNFDNF AMLTVFQC+++EGWTDV+YW+ DA+G E PW+YFV+LVI GSFFVLN
Sbjct: 310 PKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLN 369
Query: 1084 LVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDE 1263
LVLGVLSGEFSKEREKA+ARG FQK REKQQLEEDLKGYLDWITQAEDI+P NEDE DE
Sbjct: 370 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDE 429
Query: 1264 --------PVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLE------KLNXXXXXXXX 1401
P ++T ++ A R+ + + + N
Sbjct: 430 EKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCR 489
Query: 1402 XLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSL 1581
VKS FYW SEHY Q WL Q AN + LF+ EMLLKMYSL
Sbjct: 490 AAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSL 549
Query: 1582 GFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXX 1761
G Y S FNRFDCFVV ILE +LV +M PLG+SVLR RLLRIFK+T+YW
Sbjct: 550 GLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 609
Query: 1762 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALL 1941
GMQ+FGGKFNF+ Q + R+ FD F Q+LL
Sbjct: 610 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTR-RSTFDNFPQSLL 668
Query: 1942 TVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLA 2121
TVFQILTGEDWN+VMY GI ++GG G++VCIY+I+LFICGNYILLNVFLAIAVDNLA
Sbjct: 669 TVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLA 728
Query: 2122 DADSLTNA 2145
DA+SLT+A
Sbjct: 729 DAESLTSA 736
Score = 127 bits (320), Expect = 2e-27
Identities = 100/342 (29%), Positives = 160/342 (46%), Gaps = 10/342 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V NN R C IV F LILF I + I+L
Sbjct: 829 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 888
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P Q + ++N +L + VF +FTIE LK+ A G H ++ RN +NILD +
Sbjct: 889 AAEDP--VQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLL 946
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S + +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 947 VVSVSLISFGIQSSAINV--VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIV 1004
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ-KDPTPCGTDTEGSAFKCQPSDSL 852
++ + ++A IG++LF GKL+ TC D + A+ K D E QP
Sbjct: 1005 IVTTLLQFMFACIGVQLFKGKLY-TCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRS-- 1061
Query: 853 TNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWP 1032
WE N +FDN AM+ +F + EGW +++Y D+ +
Sbjct: 1062 ------WE-----------NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKG 1104
Query: 1033 WIY---------FVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
IY F+ +I+ +FF++N+ +G + F ++ E+
Sbjct: 1105 PIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1146
Score = 95.9 bits (237), Expect = 1e-17
Identities = 64/259 (24%), Positives = 124/259 (47%), Gaps = 5/259 (1%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S F +++ ++ +NT+++A +HY + D N +F E +LK+ +L
Sbjct: 492 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 551
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD VV G ++ + + + I+ R R++R+ K+ +
Sbjct: 552 QAYFVSLFNRFDCFVVCGGILETIL--VETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 609
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + + S +++ + LL+ L I++++GMQ F GK D+ + R + F +FP ++
Sbjct: 610 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT--RRSTFDNFPQSL 667
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNF----AYPYFISF 4044
L +F+ TGE W +M D G G +F YFI
Sbjct: 668 LTVFQILTGEDWNSVMY--------------DGIMAYG------GPSFPGMLVCIYFIIL 707
Query: 4045 FMLCSFLVINLFVAVIMDN 4101
F+ +++++N+F+A+ +DN
Sbjct: 708 FICGNYILLNVFLAIAVDN 726
Score = 89.7 bits (221), Expect = 7e-16
Identities = 74/315 (23%), Positives = 131/315 (41%), Gaps = 33/315 (10%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+L+ +I N I LA+ Q Y Q +K + + +F +FT+E +LK++A F
Sbjct: 1192 FEYLMFVLILLNTICLAM-QHY-GQSCLFK-IAMNILNMLFTGLFTVEMILKLIA----F 1244
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMSI---------------QGFDVKALRAFRV 582
P Y + WN+ DF+IV+ ++ ILS+ + + R FRV
Sbjct: 1245 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRV 1304
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
+R ++L+S ++ +L +++ L ++ALL++ + IYA+IG+++F
Sbjct: 1305 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF----------- 1353
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
G++A D T N NF F
Sbjct: 1354 --GKIALNDTTEI------------------------------------NRNNNFQTFPQ 1375
Query: 943 AMLTVFQCVSLEGWTDVMYWV------------------NDAVGREWPWIYFVTLVILGS 1068
A+L +F+C + E W D+M G + YF++ +L +
Sbjct: 1376 AVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCA 1435
Query: 1069 FFVLNLVLGVLSGEF 1113
F ++NL + V+ F
Sbjct: 1436 FLIINLFVAVIMDNF 1450
Score = 89.4 bits (220), Expect = 9e-16
Identities = 89/353 (25%), Positives = 144/353 (40%), Gaps = 54/353 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE +I L I N V+LA +P S L+ +F +F EA LK++A
Sbjct: 95 KPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGL 154
Query: 3511 -LNPKNYISDRWNVFD-LLVVVGSFIDITYGKLNPGGTNLIS-------INFFRLFRVMR 3663
+P Y+ + WN+ D ++VVVG F I G N + + R FRV+R
Sbjct: 155 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLR 214
Query: 3664 LVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV--------- 3813
++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F GK+
Sbjct: 215 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEG 274
Query: 3814 -----ALDDSTSI------------------------HRNNNFHSFPAAILVLFRSATGE 3906
A DD + H NF +F A+L +F+ T E
Sbjct: 275 IADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITME 334
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVA 4086
W D++ D G + YF+S + SF V+NL +
Sbjct: 335 GWTDVLYWMQD---------------------AMGYELPWVYFVSLVIFGSFFVLNLVLG 373
Query: 4087 VIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
V+ F G + +R + + D KG +LD +T I P
Sbjct: 374 VLSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 420
Score = 89.0 bits (219), Expect = 1e-15
Identities = 82/300 (27%), Positives = 130/300 (43%), Gaps = 32/300 (10%)
Frame = +1
Query: 2257 TSARPRRMSEVP---AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCIL 2427
++ R RR P ++T P+A L L+ N R C +V F +L I
Sbjct: 49 STQRKRRQYGKPKKQGSTTATRPPRA--LLCLTLKNPIRRACISIVEWKPFEIIILLTIF 106
Query: 2428 VSSAMLAAEDPLQANSTR--NMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAF 2601
+ LA P + + N L +Y F +FTVE LKVI +GL+FH ++ RN +
Sbjct: 107 ANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 166
Query: 2602 NLLDILVVAVSLTSFVL----RTDAMSXXXXXXXXXXXXXXXA---------INRAKGLK 2742
NLLD ++V V L S +L + D + A ++ L+
Sbjct: 167 NLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQ 226
Query: 2743 HVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFF-LCNDLSKMTE-------AE 2898
V+ +I A+ + +I L+ + ++AIIG++LF G C + + + +
Sbjct: 227 VVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSP 286
Query: 2899 CRGEYIH---YEDGDPTKPVSKKRVW---SNNDFNFDNVGDAMISLFVVSTFEGWPQLLY 3060
C E H ++G KP W + NFDN AM+++F T EGW +LY
Sbjct: 287 CALETGHGRQCQNGTVCKP-----GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLY 341
Score = 70.9 bits (172), Expect = 3e-10
Identities = 57/240 (23%), Positives = 98/240 (40%), Gaps = 27/240 (11%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HYGQS + N+ F LF++EM+LK+ + Y + +N FD +VI SI++
Sbjct: 1210 QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDV 1269
Query: 1657 VL--------------VYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXX 1794
+L + + + ++ R R++R+ K+
Sbjct: 1270 ILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQ 1329
Query: 1795 XXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDW 1974
GMQVFG + + NF TF QA+L +F+ TGE W
Sbjct: 1330 ALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAW 1389
Query: 1975 NTVMYHGI-------ESFGGVGTLGVIVC------IYYIVLFICGNYILLNVFLAIAVDN 2115
+M + ES T G C Y+I ++ ++++N+F+A+ +DN
Sbjct: 1390 QDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDN 1449
Score = 41.2 bits (95), Expect = 0.29
Identities = 46/240 (19%), Positives = 87/240 (36%), Gaps = 38/240 (15%)
Frame = +1
Query: 1504 DHFQTMANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYF 1671
+H ++ F +F++E+ LKM + G ++ + FN D VV S++ F +
Sbjct: 901 NHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS 960
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+ V +LR R+LR +
Sbjct: 961 AINV---VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACI 1017
Query: 1852 GMQVFGGKFNFNPQQPK------------------------PRA------NFDTFVQALL 1941
G+Q+F GK K PR+ +FD + A++
Sbjct: 1018 GVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMM 1077
Query: 1942 TVFQILTGEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+F + T E W ++Y I+S G + V + I++I+ I + ++N+F+ +
Sbjct: 1078 ALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1137
>gi|109169|pir||S11339 calcium channel protein - rabbit
gi|1508|emb|CAA39289.1| CaCB receptor [Oryctolagus cuniculus]
Length = 2166
Score = 1026 bits (2653), Expect = 0.0
Identities = 510/830 (61%), Positives = 640/830 (76%), Gaps = 12/830 (1%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPR +SE+ P+P+AS+ FI S N FR+ C+ +VN + FTN +LF IL+SS L
Sbjct: 883 RPRPLSELHLKEKAVPMPEASAFFIFSPNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 942
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP+Q S RN IL YFD FT++FT+EI LK+ +G HKGSFCRN FN+LD+LVV
Sbjct: 943 AAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVV 1002
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
+VSL SF +++ A++ AINRAKGLKHVVQCV VA++TIGNI++VT
Sbjct: 1003 SVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 1062
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG + C+D SK TEAEC+G YI Y+DG+ P+ + R W N+ F+
Sbjct: 1063 LLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFD 1122
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP+LLY +IDS+ EDKGPI+N R +++
Sbjct: 1123 FDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFM 1182
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N+ QY+VW+ V
Sbjct: 1183 MNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVN 1242
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S F+ +++ N++FTG+F E +LK++A PK+
Sbjct: 1243 STYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKH 1302
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGG------------TNLISINFFRLFRVMRLV 3669
Y D WN FD L+VVGS +DI +++P + ISI FFRLFRVMRLV
Sbjct: 1303 YFCDAWNTFDALIVVGSIVDIAITEVHPAEHTQCSPSMNAEENSRISITFFRLFRVMRLV 1362
Query: 3670 KLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNN 3849
KLLSRGEGIRTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL+D+T I+RNN
Sbjct: 1363 KLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNN 1422
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FP A+L+LFR ATGEAWQDIML+C + +C P S+ H E+ CG++FA
Sbjct: 1423 NFQTFPQAVLLLFRCATGEAWQDIMLACMPGK--KCAPESEP-HNSTEGETPCGSSFAVF 1479
Query: 4030 YFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKH 4209
YFISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+W+EYDP+AKGRIKH
Sbjct: 1480 YFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKH 1539
Query: 4210 LDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYT 4389
LDVVTLLR+I PPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFALVRT L+I T
Sbjct: 1540 LDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKT 1599
Query: 4390 EGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKK 4569
EGN+++ANE+LR+ IK+IWKRT LLD+VVPPAG +D+VTVGKFYATFLIQ+YFR+FKK
Sbjct: 1600 EGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQEYFRKFKK 1658
Query: 4570 RKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDE 4719
RKE G P+Q A++LQAGLRTLH+IGPE++RAISG+L + D+
Sbjct: 1659 RKEQGLVG-KPSQR-NALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDK 1706
Score = 712 bits (1837), Expect = 0.0
Identities = 382/723 (52%), Positives = 459/723 (62%), Gaps = 53/723 (7%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXX-XXXNNPIRKLCISIVEWKPFEFLILFMICANCIA 312
+KR KP +Q + NPIR+ CISIVEWKPFE +IL I ANC+A
Sbjct: 81 RKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVA 140
Query: 313 LAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDF 492
LAIY P+P DS+ N+ LE +EY+F+++FT+E LK++A G +FHP+AYLRN WN+LDF
Sbjct: 141 LAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDF 200
Query: 493 IIVVIGLVSTILSKMSIQ-----------GFDVKALRAFRVLRPLRLVSGVPSLQVVLNA 639
IIVV+GL S IL + + GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+
Sbjct: 201 IIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNS 260
Query: 640 ILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP--ATGQLAQKDPTPCGTDT 813
I++AM+PLLHIALLVLFVI+IYAIIGLELF GK+H TC + A+ DP+PC +T
Sbjct: 261 IIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGVADVPAEDDPSPCALET 320
Query: 814 EGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDV 993
G +CQ + ++ G W GP +GITNFDNF AMLTVFQC+++EGWTDV
Sbjct: 321 -GHGRQCQ-NGTVCKPG----------WDGPKHGITNFDNFAFAMLTVFQCITMEGWTDV 368
Query: 994 MYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQ 1173
+YWVNDAVGR+WPWIYFVTL+I+GSFFVLNLVLGVLSGEFSKEREKA+ARG FQK REKQ
Sbjct: 369 LYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 428
Query: 1174 QLEEDLKGYLDWITQAEDIEPVNEDEQEDE------------------------------ 1263
QLEEDLKGYLDWITQAEDI+P NEDE DE
Sbjct: 429 QLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNRGTPAGLHAQKKGKFAWFSHSTETH 488
Query: 1264 ---PVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLE------KLNXXXXXXXXXLVKS 1416
P ++T ++ A R+ + + + N VKS
Sbjct: 489 VSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKS 548
Query: 1417 QTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTY 1596
FYW SEHY Q WL Q AN + LF+ EMLLKMYSLG Y
Sbjct: 549 NVFYWLVIFLVFLNTLTIASEHYNQPHWLTEVQDTANKALLALFTAEMLLKMYSLGLQAY 608
Query: 1597 TTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXX 1776
S FNRFDCF+V ILE +LV +M PLG+SVLR RLLRIFK+T+YW
Sbjct: 609 FVSLFNRFDCFIVCGGILETILVETKVMSPLGISVLRCVRLLRIFKITRYWNSLSNLVAS 668
Query: 1777 XXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQI 1956
GMQ+FGGKFNF+ Q + R+ FD F Q+LLTVFQI
Sbjct: 669 LLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTR-RSTFDNFPQSLLTVFQI 727
Query: 1957 LTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSL 2136
LTGEDWN+VMY GI ++GG G++VCIY+I+LFICGNYILLNVFLAIAVDNLADA+SL
Sbjct: 728 LTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESL 787
Query: 2137 TNA 2145
T+A
Sbjct: 788 TSA 790
Score = 127 bits (318), Expect = 4e-27
Identities = 100/342 (29%), Positives = 160/342 (46%), Gaps = 10/342 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V NN R C IV F LILF I + I+L
Sbjct: 883 RPRPLSELHLKEKAVPMPEASAFFIFSPNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 942
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P Q + ++N +L + VF +FTIE LK+ A G H ++ RN +NILD +
Sbjct: 943 AAEDP--VQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLL 1000
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S + +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 1001 VVSVSLISFGIQSSAINV--VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIV 1058
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ-KDPTPCGTDTEGSAFKCQPSDSL 852
++ + ++A IG++LF GKL+ TC D + A+ K D E QP
Sbjct: 1059 IVTTLLQFMFACIGVQLFKGKLY-TCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRS-- 1115
Query: 853 TNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWP 1032
WE N +FDN AM+ +F + EGW +++Y D+ +
Sbjct: 1116 ------WE-----------NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKG 1158
Query: 1033 WIY---------FVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
IY F+ +I+ +FF++N+ +G + F ++ E+
Sbjct: 1159 PIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1200
Score = 95.9 bits (237), Expect = 1e-17
Identities = 63/259 (24%), Positives = 124/259 (47%), Gaps = 5/259 (1%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S F +++ ++ +NT+++A +HY + D N +F E +LK+ +L
Sbjct: 546 VKSNVFYWLVIFLVFLNTLTIASEHYNQPHWLTEVQDTANKALLALFTAEMLLKMYSLGL 605
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD +V G ++ + + + I+ R R++R+ K+ +
Sbjct: 606 QAYFVSLFNRFDCFIVCGGILETIL--VETKVMSPLGISVLRCVRLLRIFKITRYWNSLS 663
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + + S +++ + LL+ L I++++GMQ F GK D+ + R + F +FP ++
Sbjct: 664 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT--RRSTFDNFPQSL 721
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNF----AYPYFISF 4044
L +F+ TGE W +M D G G +F YFI
Sbjct: 722 LTVFQILTGEDWNSVMY--------------DGIMAYG------GPSFPGMLVCIYFIIL 761
Query: 4045 FMLCSFLVINLFVAVIMDN 4101
F+ +++++N+F+A+ +DN
Sbjct: 762 FICGNYILLNVFLAIAVDN 780
Score = 90.9 bits (224), Expect = 3e-16
Identities = 88/353 (24%), Positives = 148/353 (40%), Gaps = 54/353 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE +I L I N V+LA +P S L+ +F +F EA LK++A
Sbjct: 124 KPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGL 183
Query: 3511 -LNPKNYISDRWNVFD-LLVVVGSFIDITYGKLNPGGTNLIS-------INFFRLFRVMR 3663
+P Y+ + WN+ D ++VVVG F I G N + + R FRV+R
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLR 243
Query: 3664 LVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV--------- 3813
++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F GK+
Sbjct: 244 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEG 303
Query: 3814 -----ALDDSTSI------------------------HRNNNFHSFPAAILVLFRSATGE 3906
A DD + H NF +F A+L +F+ T E
Sbjct: 304 VADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITME 363
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVA 4086
W D++ +D G ++ + YF++ ++ SF V+NL +
Sbjct: 364 GWTDVLYWVND---------------------AVGRDWPWIYFVTLIIIGSFFVLNLVLG 402
Query: 4087 VIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
V+ F G + +R + + D KG +LD +T I P
Sbjct: 403 VLSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 449
Score = 89.0 bits (219), Expect = 1e-15
Identities = 77/282 (27%), Positives = 122/282 (42%), Gaps = 29/282 (10%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR--NMILNYF 2502
+L L+ N R C +V F +L I + LA P + + N L
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL----RTDAMS 2670
+Y F +FTVE LKVI +GL+FH ++ RN +NLLD ++V V L S +L + D +
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 2671 XXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
A ++ L+ V+ +I A+ + +I L+ + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 2824 AIIGVQLFKGTFF-LCNDLSKMTE-------AECRGEYIH---YEDGDPTKPVSKKRVW- 2967
AIIG++LF G C + + + + C E H ++G KP W
Sbjct: 283 AIIGLELFMGKMHKTCYNQEGVADVPAEDDPSPCALETGHGRQCQNGTVCKP-----GWD 337
Query: 2968 --SNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEED 3087
+ NFDN AM+++F T EGW +LY D+ D
Sbjct: 338 GPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRD 379
Score = 82.4 bits (202), Expect = 1e-13
Identities = 73/315 (23%), Positives = 129/315 (40%), Gaps = 33/315 (10%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+L+ +I N I LA+ Q Y Q +K + + +F +FT+E +LK++A F
Sbjct: 1246 FEYLMFVLILLNTICLAM-QHY-GQSCLFK-IAMNILNMLFTGLFTVEMILKLIA----F 1298
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKM---------------SIQGFDVKALRAFRV 582
P Y +AWN D +IVV +V ++++ + R FRV
Sbjct: 1299 KPKHYFCDAWNTFDALIVVGSIVDIAITEVHPAEHTQCSPSMNAEENSRISITFFRLFRV 1358
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
+R ++L+S ++ +L +++ L ++ALL++ + IYA+IG+++F
Sbjct: 1359 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF----------- 1407
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
G++A D T N NF F
Sbjct: 1408 --GKIALNDTTEI------------------------------------NRNNNFQTFPQ 1429
Query: 943 AMLTVFQCVSLEGWTDVMYWV------------------NDAVGREWPWIYFVTLVILGS 1068
A+L +F+C + E W D+M G + YF++ +L +
Sbjct: 1430 AVLLLFRCATGEAWQDIMLACMPGKKCAPESEPHNSTEGETPCGSSFAVFYFISFYMLCA 1489
Query: 1069 FFVLNLVLGVLSGEF 1113
F ++NL + V+ F
Sbjct: 1490 FLIINLFVAVIMDNF 1504
Score = 68.6 bits (166), Expect = 2e-09
Identities = 55/240 (22%), Positives = 95/240 (38%), Gaps = 27/240 (11%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HYGQS + N+ F LF++EM+LK+ + Y +N FD +V+ SI++
Sbjct: 1264 QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDI 1323
Query: 1657 VLVYF--------------DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXX 1794
+ + + ++ R R++R+ K+
Sbjct: 1324 AITEVHPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQ 1383
Query: 1795 XXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDW 1974
GMQVFG + + NF TF QA+L +F+ TGE W
Sbjct: 1384 ALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAW 1443
Query: 1975 NTVMYHGI-------ESFGGVGTLGVIVC------IYYIVLFICGNYILLNVFLAIAVDN 2115
+M + ES T G C Y+I ++ ++++N+F+A+ +DN
Sbjct: 1444 QDIMLACMPGKKCAPESEPHNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDN 1503
Score = 67.8 bits (164), Expect = 3e-09
Identities = 74/329 (22%), Positives = 134/329 (40%), Gaps = 9/329 (2%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALA---IYQPYPAQDSDYKNTLLETIEYVF 390
N R+ C + V+ F +L++F++ N + +A QP+ + + +T
Sbjct: 535 NRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPH------WLTEVQDTANKAL 588
Query: 391 IVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG-FDVKAL 567
+ +FT E +LK+ ++G AY + +N D IV G++ TIL + + + L
Sbjct: 589 LALFTAEMLLKMYSLGLQ----AYFVSLFNRFDCFIVCGGILETILVETKVMSPLGISVL 644
Query: 568 RAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHS 747
R R+LR ++ SL ++ ++L ++ IA L+L + L I L
Sbjct: 645 RCVRLLRIFKITRYWNSLSNLVASLLNSV---RSIASLLLLLFLFIIIFSL--------- 692
Query: 748 TCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNF 927
G G F + + F
Sbjct: 693 -----------------LGMQLFGGKFNFDEMQTRRS---------------------TF 714
Query: 928 DNFGLAMLTVFQCVSLEGWTDVMY-WVNDAVGREWP----WIYFVTLVILGSFFVLNLVL 1092
DNF ++LTVFQ ++ E W VMY + G +P IYF+ L I G++ +LN+ L
Sbjct: 715 DNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFL 774
Query: 1093 GVLSGEFSKEREKARARGLFQKFREKQQL 1179
+ + A+ ++ +E+++L
Sbjct: 775 AIAVDNLADAESLTSAQKEEEEEKERKKL 803
Score = 41.2 bits (95), Expect = 0.29
Identities = 46/240 (19%), Positives = 87/240 (36%), Gaps = 38/240 (15%)
Frame = +1
Query: 1504 DHFQTMANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYF 1671
+H ++ F +F++E+ LKM + G ++ + FN D VV S++ F +
Sbjct: 955 NHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS 1014
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+ V +LR R+LR +
Sbjct: 1015 AINV---VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACI 1071
Query: 1852 GMQVFGGKFNFNPQQPK------------------------PRA------NFDTFVQALL 1941
G+Q+F GK K PR+ +FD + A++
Sbjct: 1072 GVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMM 1131
Query: 1942 TVFQILTGEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+F + T E W ++Y I+S G + V + I++I+ I + ++N+F+ +
Sbjct: 1132 ALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1191
>gi|37591134|dbj|BAA34185.2| L-type calcium channel alpha 1 subunit
[Cavia porcellus]
Length = 2169
Score = 1025 bits (2651), Expect = 0.0
Identities = 509/830 (61%), Positives = 640/830 (76%), Gaps = 12/830 (1%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPR +SE+ P+P+AS+ FI S N FR+ C+ +VN + FTN +LF IL+SS L
Sbjct: 887 RPRPLSELHLKEKAVPMPEASAFFIFSPNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 946
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP+Q S RN IL YFD FT++FT+EI LK+ +G HKGSFCRN FN+LD+LVV
Sbjct: 947 AAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVV 1006
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
+VSL SF +++ A++ AINRAKGLKHVVQCV VA++TIGNI++VT
Sbjct: 1007 SVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 1066
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG + C+D SK TEAEC+G YI Y+DG+ +P+ + R W N+ F+
Sbjct: 1067 LLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDQPIIQPRSWENSKFD 1126
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP+LLY +IDS+ EDKGPI+N R +++
Sbjct: 1127 FDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFM 1186
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N+ QY+VW+ V
Sbjct: 1187 MNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVN 1246
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S F+ +++ N++FTG+F E +LK++A PK+
Sbjct: 1247 STYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKH 1306
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGG------------TNLISINFFRLFRVMRLV 3669
Y D WN FD L+VVGS +DI ++NP + ISI FFRLFRVMRLV
Sbjct: 1307 YFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLV 1366
Query: 3670 KLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNN 3849
KLLSRGEGIRTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL+D+T I+RNN
Sbjct: 1367 KLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNN 1426
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FP A+L+LFR ATGEAWQDIML+C + +C P SD + E+ CG++FA
Sbjct: 1427 NFQTFPQAVLLLFRCATGEAWQDIMLACMPGK--KCAPESDPSNSTE-GETPCGSSFAVF 1483
Query: 4030 YFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKH 4209
YFISF+MLC+FL+INLFVAV+MDNFDYLTRDWSILGPHHL+EF R+W+EYDP+AKGRIKH
Sbjct: 1484 YFISFYMLCAFLIINLFVAVVMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKH 1543
Query: 4210 LDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYT 4389
LDVVTLLR+I PPLGFGKLCPHR+ACKRLVSMNMPLNSDGT FNATLFALVRT L+I T
Sbjct: 1544 LDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTAMFNATLFALVRTALRIKT 1603
Query: 4390 EGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKK 4569
EGN+++ANE+LR+ IK+IWKRT LLD+VVPPAG +D+VTVGKFYATFLIQ+YFR+FKK
Sbjct: 1604 EGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQEYFRKFKK 1662
Query: 4570 RKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDE 4719
RKE G P+Q A++LQAGLRTLH+IGPE++RAISG+L + D+
Sbjct: 1663 RKEQGLVG-KPSQR-NALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDK 1710
Score = 704 bits (1817), Expect = 0.0
Identities = 374/698 (53%), Positives = 455/698 (64%), Gaps = 28/698 (4%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXX-XXXNNPIRKLCISIVEWKPFEFLILFMICANCIA 312
+KR KP +Q+ NPIR+ CISIVEWKPFE +IL I ANC+A
Sbjct: 110 RKRQQYGKPKKQSGTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVA 169
Query: 313 LAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDF 492
LAIY P+P DS+ N+ LE +EY+F+++FT+E LK++A G +FHP+AYLRN WN+LDF
Sbjct: 170 LAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDF 229
Query: 493 IIVVIGLVSTILSKMSIQ-----------GFDVKALRAFRVLRPLRLVSGVPSLQVVLNA 639
IIVV+GL S IL + + GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+
Sbjct: 230 IIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNS 289
Query: 640 ILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPA--TGQLAQKDPTPCGTDT 813
I++AM+PLLH ALLVLFVI+IYAIIGLELF GK+H TC + T A++DP+PC ++
Sbjct: 290 IIKAMVPLLHTALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGITDVPAEEDPSPCALES 349
Query: 814 EGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDV 993
G +CQ + ++ G W GP +GITNFDNF AMLTVFQC+++EGWTDV
Sbjct: 350 -GHGRQCQ-NGTVCKPG----------WDGPKHGITNFDNFAFAMLTVFQCITMEGWTDV 397
Query: 994 MYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQ 1173
+YW+ DA+G E PW+YFV+LVI GSFFVLNLVLGVLSGEFSKEREKA+ARG FQK REKQ
Sbjct: 398 LYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 457
Query: 1174 QLEEDLKGYLDWITQAEDIEPVNEDEQEDE--------PVAQTXXXXXXXXXXXXXXXXX 1329
QLEEDLKGYLDWITQAEDI+P NEDE DE P ++T
Sbjct: 458 QLEEDLKGYLDWITQAEDIDPENEDEGVDEEKPRNMSMPTSETESVNTENVAGGDIEGEN 517
Query: 1330 XPSKWAARMKRLE------KLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQ 1491
++ A R+ + + + N VKS FYW SEHY Q
Sbjct: 518 CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQ 577
Query: 1492 SEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYF 1671
WL Q AN + LF+ EMLLKMYSLG Y S FNR DCF+V ILE +LV
Sbjct: 578 PHWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRLDCFIVCGGILETILVET 637
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+M PLG+SVLR RLLRIFK+T+YW
Sbjct: 638 KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 697
Query: 1852 GMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGV 2031
GMQ+FGGKFNF+ + + R+ FD F Q+LLTVFQILTGEDWN+VMY GI ++GG G+
Sbjct: 698 GMQLFGGKFNFDEMRTR-RSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGM 756
Query: 2032 IVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNA 2145
+VCIY+I+LFICGNYILLNVFLAIAVDNLADA+SLT+A
Sbjct: 757 LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSA 794
Score = 127 bits (319), Expect = 3e-27
Identities = 100/342 (29%), Positives = 160/342 (46%), Gaps = 10/342 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V NN R C IV F LILF I + I+L
Sbjct: 887 RPRPLSELHLKEKAVPMPEASAFFIFSPNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 946
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P Q + ++N +L + VF +FTIE LK+ A G H ++ RN +NILD +
Sbjct: 947 AAEDP--VQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLL 1004
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S + +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 1005 VVSVSLISFGIQSSAIN--VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIV 1062
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ-KDPTPCGTDTEGSAFKCQPSDSL 852
++ + ++A IG++LF GKL+ TC D + A+ K D E QP
Sbjct: 1063 IVTTLLQFMFACIGVQLFKGKLY-TCSDSSKQTEAECKGNYITYKDGEVDQPIIQPRS-- 1119
Query: 853 TNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWP 1032
WE N +FDN AM+ +F + EGW +++Y D+ +
Sbjct: 1120 ------WE-----------NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKG 1162
Query: 1033 WIY---------FVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
IY F+ +I+ +FF++N+ +G + F ++ E+
Sbjct: 1163 PIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1204
Score = 93.2 bits (230), Expect = 6e-17
Identities = 62/259 (23%), Positives = 123/259 (46%), Gaps = 5/259 (1%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S F +++ ++ +NT+++A +HY + D N +F E +LK+ +L
Sbjct: 550 VKSNVFYWLVIFLVFLNTLTIASEHYNQPHWLTEVQDTANKALLALFTAEMLLKMYSLGL 609
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N D +V G ++ + + + I+ R R++R+ K+ +
Sbjct: 610 QAYFVSLFNRLDCFIVCGGILETIL--VETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 667
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + + S +++ + LL+ L I++++GMQ F GK D+ + R + F +FP ++
Sbjct: 668 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMRT--RRSTFDNFPQSL 725
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNF----AYPYFISF 4044
L +F+ TGE W +M D G G +F YFI
Sbjct: 726 LTVFQILTGEDWNSVMY--------------DGIMAYG------GPSFPGMLVCIYFIIL 765
Query: 4045 FMLCSFLVINLFVAVIMDN 4101
F+ +++++N+F+A+ +DN
Sbjct: 766 FICGNYILLNVFLAIAVDN 784
Score = 88.6 bits (218), Expect = 2e-15
Identities = 80/294 (27%), Positives = 128/294 (43%), Gaps = 29/294 (9%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
+P++ S +T P+A L L+ N R C +V F +L I + L
Sbjct: 117 KPKKQS----GTTATRPPRA--LLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVAL 170
Query: 2446 AAEDPLQANSTR--NMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDIL 2619
A P + + N L +Y F +FTVE LKVI +GL+FH ++ RN +NLLD +
Sbjct: 171 AIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFI 230
Query: 2620 VVAVSLTSFVL----RTDAMSXXXXXXXXXXXXXXXA---------INRAKGLKHVVQCV 2760
+V V L S +L + D + A ++ L+ V+ +
Sbjct: 231 IVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSI 290
Query: 2761 IVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFF-LCNDLSKMTE-------AECRGEYI 2916
I A+ + + L+ + ++AIIG++LF G C + +T+ + C E
Sbjct: 291 IKAMVPLLHTALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGITDVPAEEDPSPCALESG 350
Query: 2917 H---YEDGDPTKPVSKKRVW---SNNDFNFDNVGDAMISLFVVSTFEGWPQLLY 3060
H ++G KP W + NFDN AM+++F T EGW +LY
Sbjct: 351 HGRQCQNGTVCKP-----GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLY 399
Score = 86.7 bits (213), Expect = 6e-15
Identities = 88/353 (24%), Positives = 143/353 (39%), Gaps = 54/353 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE +I L I N V+LA +P S L+ +F +F EA LK++A
Sbjct: 153 KPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGL 212
Query: 3511 -LNPKNYISDRWNVFD-LLVVVGSFIDITYGKLNPGGTNLIS-------INFFRLFRVMR 3663
+P Y+ + WN+ D ++VVVG F I G N + + R FRV+R
Sbjct: 213 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLR 272
Query: 3664 LVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV--------- 3813
++L+S ++ +L + +K+ L + ALL++ + IYA+IG++ F GK+
Sbjct: 273 PLRLVSGVPSLQVVLNSIIKAMVPLLHTALLVLFVIIIYAIIGLELFMGKMHKTCYNQEG 332
Query: 3814 -----ALDDSTSI------------------------HRNNNFHSFPAAILVLFRSATGE 3906
A +D + H NF +F A+L +F+ T E
Sbjct: 333 ITDVPAEEDPSPCALESGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITME 392
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVA 4086
W D++ D G + YF+S + SF V+NL +
Sbjct: 393 GWTDVLYWMQD---------------------AMGYELPWVYFVSLVIFGSFFVLNLVLG 431
Query: 4087 VIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
V+ F G + +R + + D KG +LD +T I P
Sbjct: 432 VLSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 478
Score = 82.4 bits (202), Expect = 1e-13
Identities = 73/315 (23%), Positives = 130/315 (41%), Gaps = 33/315 (10%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+L+ +I N I LA+ Q Y Q +K + + +F +FT+E +LK++A F
Sbjct: 1250 FEYLMFVLILLNTICLAM-QHY-GQSCLFK-IAMNILNMLFTGLFTVEMILKLIA----F 1302
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMSI---------------QGFDVKALRAFRV 582
P Y +AWN D +IVV +V +++++ + R FRV
Sbjct: 1303 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRV 1362
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
+R ++L+S ++ +L +++ L ++ALL++ + IYA+IG+++F
Sbjct: 1363 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF----------- 1411
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
G++A D T N NF F
Sbjct: 1412 --GKIALNDTTEI------------------------------------NRNNNFQTFPQ 1433
Query: 943 AMLTVFQCVSLEGWTDVMYWV------------------NDAVGREWPWIYFVTLVILGS 1068
A+L +F+C + E W D+M G + YF++ +L +
Sbjct: 1434 AVLLLFRCATGEAWQDIMLACMPGKKCAPESDPSNSTEGETPCGSSFAVFYFISFYMLCA 1493
Query: 1069 FFVLNLVLGVLSGEF 1113
F ++NL + V+ F
Sbjct: 1494 FLIINLFVAVVMDNF 1508
Score = 70.1 bits (170), Expect = 6e-10
Identities = 55/240 (22%), Positives = 96/240 (39%), Gaps = 27/240 (11%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HYGQS + N+ F LF++EM+LK+ + Y +N FD +V+ SI++
Sbjct: 1268 QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDI 1327
Query: 1657 VLVYFDLMKP--------------LGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXX 1794
+ + + + ++ R R++R+ K+
Sbjct: 1328 AITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQ 1387
Query: 1795 XXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDW 1974
GMQVFG + + NF TF QA+L +F+ TGE W
Sbjct: 1388 ALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAW 1447
Query: 1975 NTVMYHGI-------ESFGGVGTLGVIVC------IYYIVLFICGNYILLNVFLAIAVDN 2115
+M + ES T G C Y+I ++ ++++N+F+A+ +DN
Sbjct: 1448 QDIMLACMPGKKCAPESDPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVVMDN 1507
Score = 42.0 bits (97), Expect = 0.17
Identities = 47/240 (19%), Positives = 90/240 (36%), Gaps = 38/240 (15%)
Frame = +1
Query: 1504 DHFQTMANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYF 1671
+H ++ F +F++E+ LKM + G ++ + FN D VV S++ F +
Sbjct: 959 NHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS 1018
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+ V +LR R+LR +
Sbjct: 1019 AINV---VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACI 1075
Query: 1852 GMQVFGGKF----------------------NFNPQQP--KPRA------NFDTFVQALL 1941
G+Q+F GK + QP +PR+ +FD + A++
Sbjct: 1076 GVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDQPIIQPRSWENSKFDFDNVLAAMM 1135
Query: 1942 TVFQILTGEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+F + T E W ++Y I+S G + V + I++I+ I + ++N+F+ +
Sbjct: 1136 ALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1195
>gi|27597080|ref|NP_000710.3| calcium channel, voltage-dependent, L
type, alpha 1C subunit [Homo sapiens]
gi|21636579|gb|AAM70049.1| jejunum L-type calcium channel alpha1C
subunit [Homo sapiens]
Length = 2138
Score = 1025 bits (2651), Expect = 0.0
Identities = 510/830 (61%), Positives = 640/830 (76%), Gaps = 12/830 (1%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPR +SE+ P+P+AS+ FI S N FR+ C+ +VN + FTN +LF IL+SS L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP+Q S RN IL YFD FT++FT+EI LK+ +G HKGSFCRN FN+LD+LVV
Sbjct: 918 AAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVV 977
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
+VSL SF +++ A++ AINRAKGLKHVVQCV VA++TIGNI++VT
Sbjct: 978 SVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 1037
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG + C+D SK TEAEC+G YI Y+DG+ P+ + R W N+ F+
Sbjct: 1038 LLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFD 1097
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP+LLY +IDS+ EDKGPI+N R +++
Sbjct: 1098 FDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFM 1157
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N+ QY+VW+ V
Sbjct: 1158 MNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVN 1217
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S F+ +++ N++FTG+F E +LK++A PK+
Sbjct: 1218 STYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKH 1277
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGG------------TNLISINFFRLFRVMRLV 3669
Y D WN FD L+VVGS +DI ++NP + ISI FFRLFRVMRLV
Sbjct: 1278 YFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLV 1337
Query: 3670 KLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNN 3849
KLLSRGEGIRTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL+D+T I+RNN
Sbjct: 1338 KLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNN 1397
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FP A+L+LFR ATGEAWQDIML+C + +C P S+ + E+ CG++FA
Sbjct: 1398 NFQTFPQAVLLLFRCATGEAWQDIMLACMPGK--KCAPESEPSNSTE-GETPCGSSFAVF 1454
Query: 4030 YFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKH 4209
YFISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+W+EYDP+AKGRIKH
Sbjct: 1455 YFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKH 1514
Query: 4210 LDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYT 4389
LDVVTLLR+I PPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFALVRT L+I T
Sbjct: 1515 LDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKT 1574
Query: 4390 EGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKK 4569
EGN+++ANE+LR+ IK+IWKRT LLD+VVPPAG +D+VTVGKFYATFLIQ+YFR+FKK
Sbjct: 1575 EGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQEYFRKFKK 1633
Query: 4570 RKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDE 4719
RKE G P+Q A++LQAGLRTLH+IGPE++RAISG+L + D+
Sbjct: 1634 RKEQGLVG-KPSQR-NALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDK 1681
Score = 722 bits (1863), Expect = 0.0
Identities = 383/698 (54%), Positives = 459/698 (64%), Gaps = 28/698 (4%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXX-XXXNNPIRKLCISIVEWKPFEFLILFMICANCIA 312
+KR KP +Q + NPIR+ CISIVEWKPFE +IL I ANC+A
Sbjct: 81 RKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVA 140
Query: 313 LAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDF 492
LAIY P+P DS+ N+ LE +EY+F+++FT+E LK++A G +FHP+AYLRN WN+LDF
Sbjct: 141 LAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDF 200
Query: 493 IIVVIGLVSTILSKMSIQ-----------GFDVKALRAFRVLRPLRLVSGVPSLQVVLNA 639
IIVV+GL S IL + + GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+
Sbjct: 201 IIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNS 260
Query: 640 ILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPA--TGQLAQKDPTPCGTDT 813
I++AM+PLLHIALLVLFVI+IYAIIGLELF GK+H TC + A+ DP+PC +T
Sbjct: 261 IIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALET 320
Query: 814 EGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDV 993
G +CQ + ++ G W GP +GITNFDNF AMLTVFQC+++EGWTDV
Sbjct: 321 -GHGRQCQ-NGTVCKPG----------WDGPKHGITNFDNFAFAMLTVFQCITMEGWTDV 368
Query: 994 MYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQ 1173
+YWVNDAVGR+WPWIYFVTL+I+GSFFVLNLVLGVLSGEFSKEREKA+ARG FQK REKQ
Sbjct: 369 LYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 428
Query: 1174 QLEEDLKGYLDWITQAEDIEPVNEDEQEDE--------PVAQTXXXXXXXXXXXXXXXXX 1329
QLEEDLKGYLDWITQAEDI+P NEDE DE P ++T
Sbjct: 429 QLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGEN 488
Query: 1330 XPSKWAARMKRLE------KLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQ 1491
++ A R+ + + + N VKS FYW SEHY Q
Sbjct: 489 CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQ 548
Query: 1492 SEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYF 1671
WL Q AN + LF+ EMLLKMYSLG Y S FNRFDCFVV ILE +LV
Sbjct: 549 PNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+M PLG+SVLR RLLRIFK+T+YW
Sbjct: 609 KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668
Query: 1852 GMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGV 2031
GMQ+FGGKFNF+ Q + R+ FD F Q+LLTVFQILTGEDWN+VMY GI ++GG G+
Sbjct: 669 GMQLFGGKFNFDEMQTR-RSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGM 727
Query: 2032 IVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNA 2145
+VCIY+I+LFICGNYILLNVFLAIAVDNLADA+SLT+A
Sbjct: 728 LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSA 765
Score = 127 bits (320), Expect = 2e-27
Identities = 100/342 (29%), Positives = 160/342 (46%), Gaps = 10/342 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V NN R C IV F LILF I + I+L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P Q + ++N +L + VF +FTIE LK+ A G H ++ RN +NILD +
Sbjct: 918 AAEDP--VQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLL 975
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S + +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 976 VVSVSLISFGIQSSAINV--VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIV 1033
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ-KDPTPCGTDTEGSAFKCQPSDSL 852
++ + ++A IG++LF GKL+ TC D + A+ K D E QP
Sbjct: 1034 IVTTLLQFMFACIGVQLFKGKLY-TCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRS-- 1090
Query: 853 TNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWP 1032
WE N +FDN AM+ +F + EGW +++Y D+ +
Sbjct: 1091 ------WE-----------NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKG 1133
Query: 1033 WIY---------FVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
IY F+ +I+ +FF++N+ +G + F ++ E+
Sbjct: 1134 PIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1175
Score = 95.9 bits (237), Expect = 1e-17
Identities = 64/259 (24%), Positives = 124/259 (47%), Gaps = 5/259 (1%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S F +++ ++ +NT+++A +HY + D N +F E +LK+ +L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD VV G ++ + + + I+ R R++R+ K+ +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL--VETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + + S +++ + LL+ L I++++GMQ F GK D+ + R + F +FP ++
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT--RRSTFDNFPQSL 696
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNF----AYPYFISF 4044
L +F+ TGE W +M D G G +F YFI
Sbjct: 697 LTVFQILTGEDWNSVMY--------------DGIMAYG------GPSFPGMLVCIYFIIL 736
Query: 4045 FMLCSFLVINLFVAVIMDN 4101
F+ +++++N+F+A+ +DN
Sbjct: 737 FICGNYILLNVFLAIAVDN 755
Score = 90.9 bits (224), Expect = 3e-16
Identities = 88/353 (24%), Positives = 148/353 (40%), Gaps = 54/353 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE +I L I N V+LA +P S L+ +F +F EA LK++A
Sbjct: 124 KPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGL 183
Query: 3511 -LNPKNYISDRWNVFD-LLVVVGSFIDITYGKLNPGGTNLIS-------INFFRLFRVMR 3663
+P Y+ + WN+ D ++VVVG F I G N + + R FRV+R
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLR 243
Query: 3664 LVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV--------- 3813
++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F GK+
Sbjct: 244 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEG 303
Query: 3814 -----ALDDSTSI------------------------HRNNNFHSFPAAILVLFRSATGE 3906
A DD + H NF +F A+L +F+ T E
Sbjct: 304 IADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITME 363
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVA 4086
W D++ +D G ++ + YF++ ++ SF V+NL +
Sbjct: 364 GWTDVLYWVND---------------------AVGRDWPWIYFVTLIIIGSFFVLNLVLG 402
Query: 4087 VIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
V+ F G + +R + + D KG +LD +T I P
Sbjct: 403 VLSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 449
Score = 89.0 bits (219), Expect = 1e-15
Identities = 77/282 (27%), Positives = 122/282 (42%), Gaps = 29/282 (10%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR--NMILNYF 2502
+L L+ N R C +V F +L I + LA P + + N L
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL----RTDAMS 2670
+Y F +FTVE LKVI +GL+FH ++ RN +NLLD ++V V L S +L + D +
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 2671 XXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
A ++ L+ V+ +I A+ + +I L+ + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 2824 AIIGVQLFKGTFF-LCNDLSKMTE-------AECRGEYIH---YEDGDPTKPVSKKRVW- 2967
AIIG++LF G C + + + + C E H ++G KP W
Sbjct: 283 AIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKP-----GWD 337
Query: 2968 --SNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEED 3087
+ NFDN AM+++F T EGW +LY D+ D
Sbjct: 338 GPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRD 379
Score = 82.8 bits (203), Expect = 9e-14
Identities = 73/315 (23%), Positives = 130/315 (41%), Gaps = 33/315 (10%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+L+ +I N I LA+ Q Y Q +K + + +F +FT+E +LK++A F
Sbjct: 1221 FEYLMFVLILLNTICLAM-QHY-GQSCLFK-IAMNILNMLFTGLFTVEMILKLIA----F 1273
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMSI---------------QGFDVKALRAFRV 582
P Y +AWN D +IVV +V +++++ + R FRV
Sbjct: 1274 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRV 1333
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
+R ++L+S ++ +L +++ L ++ALL++ + IYA+IG+++F
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF----------- 1382
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
G++A D T N NF F
Sbjct: 1383 --GKIALNDTTEI------------------------------------NRNNNFQTFPQ 1404
Query: 943 AMLTVFQCVSLEGWTDVMYWV------------------NDAVGREWPWIYFVTLVILGS 1068
A+L +F+C + E W D+M G + YF++ +L +
Sbjct: 1405 AVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCA 1464
Query: 1069 FFVLNLVLGVLSGEF 1113
F ++NL + V+ F
Sbjct: 1465 FLIINLFVAVIMDNF 1479
Score = 69.7 bits (169), Expect = 8e-10
Identities = 55/240 (22%), Positives = 96/240 (39%), Gaps = 27/240 (11%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HYGQS + N+ F LF++EM+LK+ + Y +N FD +V+ SI++
Sbjct: 1239 QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDI 1298
Query: 1657 VLVYFDLMKP--------------LGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXX 1794
+ + + + ++ R R++R+ K+
Sbjct: 1299 AITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQ 1358
Query: 1795 XXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDW 1974
GMQVFG + + NF TF QA+L +F+ TGE W
Sbjct: 1359 ALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAW 1418
Query: 1975 NTVMYHGI-------ESFGGVGTLGVIVC------IYYIVLFICGNYILLNVFLAIAVDN 2115
+M + ES T G C Y+I ++ ++++N+F+A+ +DN
Sbjct: 1419 QDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDN 1478
Score = 41.2 bits (95), Expect = 0.29
Identities = 46/240 (19%), Positives = 87/240 (36%), Gaps = 38/240 (15%)
Frame = +1
Query: 1504 DHFQTMANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYF 1671
+H ++ F +F++E+ LKM + G ++ + FN D VV S++ F +
Sbjct: 930 NHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS 989
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+ V +LR R+LR +
Sbjct: 990 AINV---VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACI 1046
Query: 1852 GMQVFGGKFNFNPQQPK------------------------PRA------NFDTFVQALL 1941
G+Q+F GK K PR+ +FD + A++
Sbjct: 1047 GVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMM 1106
Query: 1942 TVFQILTGEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+F + T E W ++Y I+S G + V + I++I+ I + ++N+F+ +
Sbjct: 1107 ALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1166
>gi|508183|emb|CAA84340.1| voltage-dependent L-type Ca channel alpha 1
subunit [Homo sapiens]
Length = 2138
Score = 1025 bits (2651), Expect = 0.0
Identities = 511/830 (61%), Positives = 639/830 (76%), Gaps = 12/830 (1%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPR +SE+ P+P+AS+ FI S N FR+ C+ +VN + FTN +LF IL+SS L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP+Q S RN IL DY FTS+FT+EI LK+ +G HKGSFCRN FN+LD+LVV
Sbjct: 918 AAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVV 977
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
+VSL SF +++ A++ AINRAKGLKHVVQCV VA++TIGNI++VT
Sbjct: 978 SVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 1037
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG + C+D SK TEAEC+G YI Y+DG+ P+ + R W N+ F+
Sbjct: 1038 LLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFD 1097
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP+LLY +IDS+ EDKGPI+N R +++
Sbjct: 1098 FDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFM 1157
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N+ QY+VW+ V
Sbjct: 1158 MNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVN 1217
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S F+ +++ N++FTG+F E +LK++A PK
Sbjct: 1218 STYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKG 1277
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGG------------TNLISINFFRLFRVMRLV 3669
Y SD WNVFD L+V+GS ID+ + NP + ISI FFRLFRVMRLV
Sbjct: 1278 YFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLV 1337
Query: 3670 KLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNN 3849
KLLSRGEGIRTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL+D+T I+RNN
Sbjct: 1338 KLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNN 1397
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FP A+L+LFR ATGEAWQDIML+C + +C P S+ + E+ CG++FA
Sbjct: 1398 NFQTFPQAVLLLFRCATGEAWQDIMLACMPGK--KCAPESEPSNSTE-GETPCGSSFAVF 1454
Query: 4030 YFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKH 4209
YFISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+W+EYDP+AKGRIKH
Sbjct: 1455 YFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKH 1514
Query: 4210 LDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYT 4389
LDVVTLLR+I PPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFALVRT L+I T
Sbjct: 1515 LDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKT 1574
Query: 4390 EGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKK 4569
EGN+++ANE+LR+ IK+IWKRT LLD+VVPPAG +D+VTVGKFYATFLIQ+YFR+FKK
Sbjct: 1575 EGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQEYFRKFKK 1633
Query: 4570 RKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDE 4719
RKE G P+Q A++LQAGLRTLH+IGPE++RAISG+L + D+
Sbjct: 1634 RKEQGLVG-KPSQR-NALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDK 1681
Score = 722 bits (1863), Expect = 0.0
Identities = 383/698 (54%), Positives = 459/698 (64%), Gaps = 28/698 (4%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXX-XXXNNPIRKLCISIVEWKPFEFLILFMICANCIA 312
+KR KP +Q + NPIR+ CISIVEWKPFE +IL I ANC+A
Sbjct: 81 RKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVA 140
Query: 313 LAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDF 492
LAIY P+P DS+ N+ LE +EY+F+++FT+E LK++A G +FHP+AYLRN WN+LDF
Sbjct: 141 LAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDF 200
Query: 493 IIVVIGLVSTILSKMSIQ-----------GFDVKALRAFRVLRPLRLVSGVPSLQVVLNA 639
IIVV+GL S IL + + GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+
Sbjct: 201 IIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNS 260
Query: 640 ILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPA--TGQLAQKDPTPCGTDT 813
I++AM+PLLHIALLVLFVI+IYAIIGLELF GK+H TC + A+ DP+PC +T
Sbjct: 261 IIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALET 320
Query: 814 EGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDV 993
G +CQ + ++ G W GP +GITNFDNF AMLTVFQC+++EGWTDV
Sbjct: 321 -GHGRQCQ-NGTVCKPG----------WDGPKHGITNFDNFAFAMLTVFQCITMEGWTDV 368
Query: 994 MYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQ 1173
+YWVNDAVGR+WPWIYFVTL+I+GSFFVLNLVLGVLSGEFSKEREKA+ARG FQK REKQ
Sbjct: 369 LYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 428
Query: 1174 QLEEDLKGYLDWITQAEDIEPVNEDEQEDE--------PVAQTXXXXXXXXXXXXXXXXX 1329
QLEEDLKGYLDWITQAEDI+P NEDE DE P ++T
Sbjct: 429 QLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGEN 488
Query: 1330 XPSKWAARMKRLE------KLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQ 1491
++ A R+ + + + N VKS FYW SEHY Q
Sbjct: 489 CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQ 548
Query: 1492 SEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYF 1671
WL Q AN + LF+ EMLLKMYSLG Y S FNRFDCFVV ILE +LV
Sbjct: 549 PNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+M PLG+SVLR RLLRIFK+T+YW
Sbjct: 609 KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668
Query: 1852 GMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGV 2031
GMQ+FGGKFNF+ Q + R+ FD F Q+LLTVFQILTGEDWN+VMY GI ++GG G+
Sbjct: 669 GMQLFGGKFNFDEMQTR-RSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGM 727
Query: 2032 IVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNA 2145
+VCIY+I+LFICGNYILLNVFLAIAVDNLADA+SLT+A
Sbjct: 728 LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSA 765
Score = 131 bits (329), Expect = 2e-28
Identities = 100/342 (29%), Positives = 162/342 (47%), Gaps = 10/342 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V NN R C IV F LILF I + I+L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P Q + ++N +L +YVF +FT+E +LK+ A G H ++ RN +NILD +
Sbjct: 918 AAEDP--VQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLL 975
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S + +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 976 VVSVSLISFGIQSSAINV--VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIV 1033
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ-KDPTPCGTDTEGSAFKCQPSDSL 852
++ + ++A IG++LF GKL+ TC D + A+ K D E QP
Sbjct: 1034 IVTTLLQFMFACIGVQLFKGKLY-TCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRS-- 1090
Query: 853 TNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWP 1032
WE N +FDN AM+ +F + EGW +++Y D+ +
Sbjct: 1091 ------WE-----------NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKG 1133
Query: 1033 WIY---------FVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
IY F+ +I+ +FF++N+ +G + F ++ E+
Sbjct: 1134 PIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1175
Score = 95.9 bits (237), Expect = 1e-17
Identities = 64/259 (24%), Positives = 124/259 (47%), Gaps = 5/259 (1%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S F +++ ++ +NT+++A +HY + D N +F E +LK+ +L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD VV G ++ + + + I+ R R++R+ K+ +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL--VETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + + S +++ + LL+ L I++++GMQ F GK D+ + R + F +FP ++
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT--RRSTFDNFPQSL 696
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNF----AYPYFISF 4044
L +F+ TGE W +M D G G +F YFI
Sbjct: 697 LTVFQILTGEDWNSVMY--------------DGIMAYG------GPSFPGMLVCIYFIIL 736
Query: 4045 FMLCSFLVINLFVAVIMDN 4101
F+ +++++N+F+A+ +DN
Sbjct: 737 FICGNYILLNVFLAIAVDN 755
Score = 90.9 bits (224), Expect = 3e-16
Identities = 88/353 (24%), Positives = 148/353 (40%), Gaps = 54/353 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE +I L I N V+LA +P S L+ +F +F EA LK++A
Sbjct: 124 KPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGL 183
Query: 3511 -LNPKNYISDRWNVFD-LLVVVGSFIDITYGKLNPGGTNLIS-------INFFRLFRVMR 3663
+P Y+ + WN+ D ++VVVG F I G N + + R FRV+R
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLR 243
Query: 3664 LVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV--------- 3813
++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F GK+
Sbjct: 244 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEG 303
Query: 3814 -----ALDDSTSI------------------------HRNNNFHSFPAAILVLFRSATGE 3906
A DD + H NF +F A+L +F+ T E
Sbjct: 304 IADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITME 363
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVA 4086
W D++ +D G ++ + YF++ ++ SF V+NL +
Sbjct: 364 GWTDVLYWVND---------------------AVGRDWPWIYFVTLIIIGSFFVLNLVLG 402
Query: 4087 VIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
V+ F G + +R + + D KG +LD +T I P
Sbjct: 403 VLSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 449
Score = 89.7 bits (221), Expect = 7e-16
Identities = 74/315 (23%), Positives = 131/315 (41%), Gaps = 33/315 (10%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+L+ +I N I LA+ Q Y Q +K + + +F +FT+E +LK++A F
Sbjct: 1221 FEYLMFVLILLNTICLAM-QHY-GQSCLFK-IAMNILNMLFTGLFTVEMILKLIA----F 1273
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMSI---------------QGFDVKALRAFRV 582
P Y + WN+ DF+IV+ ++ ILS+ + + R FRV
Sbjct: 1274 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRV 1333
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
+R ++L+S ++ +L +++ L ++ALL++ + IYA+IG+++F
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF----------- 1382
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
G++A D T N NF F
Sbjct: 1383 --GKIALNDTTEI------------------------------------NRNNNFQTFPQ 1404
Query: 943 AMLTVFQCVSLEGWTDVMYWV------------------NDAVGREWPWIYFVTLVILGS 1068
A+L +F+C + E W D+M G + YF++ +L +
Sbjct: 1405 AVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCA 1464
Query: 1069 FFVLNLVLGVLSGEF 1113
F ++NL + V+ F
Sbjct: 1465 FLIINLFVAVIMDNF 1479
Score = 89.0 bits (219), Expect = 1e-15
Identities = 77/282 (27%), Positives = 122/282 (42%), Gaps = 29/282 (10%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR--NMILNYF 2502
+L L+ N R C +V F +L I + LA P + + N L
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL----RTDAMS 2670
+Y F +FTVE LKVI +GL+FH ++ RN +NLLD ++V V L S +L + D +
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 2671 XXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
A ++ L+ V+ +I A+ + +I L+ + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 2824 AIIGVQLFKGTFF-LCNDLSKMTE-------AECRGEYIH---YEDGDPTKPVSKKRVW- 2967
AIIG++LF G C + + + + C E H ++G KP W
Sbjct: 283 AIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKP-----GWD 337
Query: 2968 --SNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEED 3087
+ NFDN AM+++F T EGW +LY D+ D
Sbjct: 338 GPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRD 379
Score = 70.9 bits (172), Expect = 3e-10
Identities = 57/240 (23%), Positives = 98/240 (40%), Gaps = 27/240 (11%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HYGQS + N+ F LF++EM+LK+ + Y + +N FD +VI SI++
Sbjct: 1239 QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDV 1298
Query: 1657 VL--------------VYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXX 1794
+L + + + ++ R R++R+ K+
Sbjct: 1299 ILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQ 1358
Query: 1795 XXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDW 1974
GMQVFG + + NF TF QA+L +F+ TGE W
Sbjct: 1359 ALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAW 1418
Query: 1975 NTVMYHGI-------ESFGGVGTLGVIVC------IYYIVLFICGNYILLNVFLAIAVDN 2115
+M + ES T G C Y+I ++ ++++N+F+A+ +DN
Sbjct: 1419 QDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDN 1478
Score = 43.1 bits (100), Expect = 0.077
Identities = 47/240 (19%), Positives = 88/240 (36%), Gaps = 38/240 (15%)
Frame = +1
Query: 1504 DHFQTMANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYF 1671
+H A+ F +F++E++LKM + G ++ + FN D VV S++ F +
Sbjct: 930 NHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS 989
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+ V +LR R+LR +
Sbjct: 990 AINV---VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACI 1046
Query: 1852 GMQVFGGKFNFNPQQPK------------------------PRA------NFDTFVQALL 1941
G+Q+F GK K PR+ +FD + A++
Sbjct: 1047 GVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMM 1106
Query: 1942 TVFQILTGEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+F + T E W ++Y I+S G + V + I++I+ I + ++N+F+ +
Sbjct: 1107 ALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1166
>gi|508195|emb|CAA84341.1| voltage-dependent L-type Ca channel alpha 1
subunit [Homo sapiens]
Length = 2138
Score = 1025 bits (2651), Expect = 0.0
Identities = 510/830 (61%), Positives = 640/830 (76%), Gaps = 12/830 (1%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPR +SE+ P+P+AS+ FI S N FR+ C+ +VN + FTN +LF IL+SS L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP+Q S RN IL YFD FT++FT+EI LK+ +G HKGSFCRN FN+LD+LVV
Sbjct: 918 AAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVV 977
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
+VSL SF +++ A++ AINRAKGLKHVVQCV VA++TIGNI++VT
Sbjct: 978 SVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 1037
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG + C+D SK TEAEC+G YI Y+DG+ P+ + R W N+ F+
Sbjct: 1038 LLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFD 1097
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP+LLY +IDS+ EDKGPI+N R +++
Sbjct: 1098 FDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFM 1157
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N+ QY+VW+ V
Sbjct: 1158 MNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVN 1217
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S F+ +++ N++FTG+F E +LK++A PK+
Sbjct: 1218 STYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKH 1277
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGG------------TNLISINFFRLFRVMRLV 3669
Y D WN FD L+VVGS +DI ++NP + ISI FFRLFRVMRLV
Sbjct: 1278 YFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLV 1337
Query: 3670 KLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNN 3849
KLLSRGEGIRTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL+D+T I+RNN
Sbjct: 1338 KLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNN 1397
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FP A+L+LFR ATGEAWQDIML+C + +C P S+ + E+ CG++FA
Sbjct: 1398 NFQTFPQAVLLLFRCATGEAWQDIMLACMPGK--KCAPESEPSNSTE-GETPCGSSFAVF 1454
Query: 4030 YFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKH 4209
YFISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+W+EYDP+AKGRIKH
Sbjct: 1455 YFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKH 1514
Query: 4210 LDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYT 4389
LDVVTLLR+I PPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFALVRT L+I T
Sbjct: 1515 LDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKT 1574
Query: 4390 EGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKK 4569
EGN+++ANE+LR+ IK+IWKRT LLD+VVPPAG +D+VTVGKFYATFLIQ+YFR+FKK
Sbjct: 1575 EGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQEYFRKFKK 1633
Query: 4570 RKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDE 4719
RKE G P+Q A++LQAGLRTLH+IGPE++RAISG+L + D+
Sbjct: 1634 RKEQGLVG-KPSQR-NALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDK 1681
Score = 722 bits (1863), Expect = 0.0
Identities = 383/698 (54%), Positives = 459/698 (64%), Gaps = 28/698 (4%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXX-XXXNNPIRKLCISIVEWKPFEFLILFMICANCIA 312
+KR KP +Q + NPIR+ CISIVEWKPFE +IL I ANC+A
Sbjct: 81 RKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVA 140
Query: 313 LAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDF 492
LAIY P+P DS+ N+ LE +EY+F+++FT+E LK++A G +FHP+AYLRN WN+LDF
Sbjct: 141 LAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDF 200
Query: 493 IIVVIGLVSTILSKMSIQ-----------GFDVKALRAFRVLRPLRLVSGVPSLQVVLNA 639
IIVV+GL S IL + + GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+
Sbjct: 201 IIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNS 260
Query: 640 ILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPA--TGQLAQKDPTPCGTDT 813
I++AM+PLLHIALLVLFVI+IYAIIGLELF GK+H TC + A+ DP+PC +T
Sbjct: 261 IIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALET 320
Query: 814 EGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDV 993
G +CQ + ++ G W GP +GITNFDNF AMLTVFQC+++EGWTDV
Sbjct: 321 -GHGRQCQ-NGTVCKPG----------WDGPKHGITNFDNFAFAMLTVFQCITMEGWTDV 368
Query: 994 MYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQ 1173
+YWVNDAVGR+WPWIYFVTL+I+GSFFVLNLVLGVLSGEFSKEREKA+ARG FQK REKQ
Sbjct: 369 LYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 428
Query: 1174 QLEEDLKGYLDWITQAEDIEPVNEDEQEDE--------PVAQTXXXXXXXXXXXXXXXXX 1329
QLEEDLKGYLDWITQAEDI+P NEDE DE P ++T
Sbjct: 429 QLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGEN 488
Query: 1330 XPSKWAARMKRLE------KLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQ 1491
++ A R+ + + + N VKS FYW SEHY Q
Sbjct: 489 CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQ 548
Query: 1492 SEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYF 1671
WL Q AN + LF+ EMLLKMYSLG Y S FNRFDCFVV ILE +LV
Sbjct: 549 PNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+M PLG+SVLR RLLRIFK+T+YW
Sbjct: 609 KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668
Query: 1852 GMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGV 2031
GMQ+FGGKFNF+ Q + R+ FD F Q+LLTVFQILTGEDWN+VMY GI ++GG G+
Sbjct: 669 GMQLFGGKFNFDEMQTR-RSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGM 727
Query: 2032 IVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNA 2145
+VCIY+I+LFICGNYILLNVFLAIAVDNLADA+SLT+A
Sbjct: 728 LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSA 765
Score = 127 bits (320), Expect = 2e-27
Identities = 100/342 (29%), Positives = 160/342 (46%), Gaps = 10/342 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V NN R C IV F LILF I + I+L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P Q + ++N +L + VF +FTIE LK+ A G H ++ RN +NILD +
Sbjct: 918 AAEDP--VQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLL 975
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S + +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 976 VVSVSLISFGIQSSAINV--VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIV 1033
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ-KDPTPCGTDTEGSAFKCQPSDSL 852
++ + ++A IG++LF GKL+ TC D + A+ K D E QP
Sbjct: 1034 IVTTLLQFMFACIGVQLFKGKLY-TCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRS-- 1090
Query: 853 TNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWP 1032
WE N +FDN AM+ +F + EGW +++Y D+ +
Sbjct: 1091 ------WE-----------NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKG 1133
Query: 1033 WIY---------FVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
IY F+ +I+ +FF++N+ +G + F ++ E+
Sbjct: 1134 PIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1175
Score = 95.9 bits (237), Expect = 1e-17
Identities = 64/259 (24%), Positives = 124/259 (47%), Gaps = 5/259 (1%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S F +++ ++ +NT+++A +HY + D N +F E +LK+ +L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD VV G ++ + + + I+ R R++R+ K+ +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL--VETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + + S +++ + LL+ L I++++GMQ F GK D+ + R + F +FP ++
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT--RRSTFDNFPQSL 696
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNF----AYPYFISF 4044
L +F+ TGE W +M D G G +F YFI
Sbjct: 697 LTVFQILTGEDWNSVMY--------------DGIMAYG------GPSFPGMLVCIYFIIL 736
Query: 4045 FMLCSFLVINLFVAVIMDN 4101
F+ +++++N+F+A+ +DN
Sbjct: 737 FICGNYILLNVFLAIAVDN 755
Score = 90.9 bits (224), Expect = 3e-16
Identities = 88/353 (24%), Positives = 148/353 (40%), Gaps = 54/353 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE +I L I N V+LA +P S L+ +F +F EA LK++A
Sbjct: 124 KPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGL 183
Query: 3511 -LNPKNYISDRWNVFD-LLVVVGSFIDITYGKLNPGGTNLIS-------INFFRLFRVMR 3663
+P Y+ + WN+ D ++VVVG F I G N + + R FRV+R
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLR 243
Query: 3664 LVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV--------- 3813
++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F GK+
Sbjct: 244 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEG 303
Query: 3814 -----ALDDSTSI------------------------HRNNNFHSFPAAILVLFRSATGE 3906
A DD + H NF +F A+L +F+ T E
Sbjct: 304 IADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITME 363
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVA 4086
W D++ +D G ++ + YF++ ++ SF V+NL +
Sbjct: 364 GWTDVLYWVND---------------------AVGRDWPWIYFVTLIIIGSFFVLNLVLG 402
Query: 4087 VIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
V+ F G + +R + + D KG +LD +T I P
Sbjct: 403 VLSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 449
Score = 89.0 bits (219), Expect = 1e-15
Identities = 77/282 (27%), Positives = 122/282 (42%), Gaps = 29/282 (10%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR--NMILNYF 2502
+L L+ N R C +V F +L I + LA P + + N L
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL----RTDAMS 2670
+Y F +FTVE LKVI +GL+FH ++ RN +NLLD ++V V L S +L + D +
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 2671 XXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
A ++ L+ V+ +I A+ + +I L+ + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 2824 AIIGVQLFKGTFF-LCNDLSKMTE-------AECRGEYIH---YEDGDPTKPVSKKRVW- 2967
AIIG++LF G C + + + + C E H ++G KP W
Sbjct: 283 AIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKP-----GWD 337
Query: 2968 --SNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEED 3087
+ NFDN AM+++F T EGW +LY D+ D
Sbjct: 338 GPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRD 379
Score = 82.8 bits (203), Expect = 9e-14
Identities = 73/315 (23%), Positives = 130/315 (41%), Gaps = 33/315 (10%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+L+ +I N I LA+ Q Y Q +K + + +F +FT+E +LK++A F
Sbjct: 1221 FEYLMFVLILLNTICLAM-QHY-GQSCLFK-IAMNILNMLFTGLFTVEMILKLIA----F 1273
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMSI---------------QGFDVKALRAFRV 582
P Y +AWN D +IVV +V +++++ + R FRV
Sbjct: 1274 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRV 1333
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
+R ++L+S ++ +L +++ L ++ALL++ + IYA+IG+++F
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF----------- 1382
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
G++A D T N NF F
Sbjct: 1383 --GKIALNDTTEI------------------------------------NRNNNFQTFPQ 1404
Query: 943 AMLTVFQCVSLEGWTDVMYWV------------------NDAVGREWPWIYFVTLVILGS 1068
A+L +F+C + E W D+M G + YF++ +L +
Sbjct: 1405 AVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCA 1464
Query: 1069 FFVLNLVLGVLSGEF 1113
F ++NL + V+ F
Sbjct: 1465 FLIINLFVAVIMDNF 1479
Score = 69.7 bits (169), Expect = 8e-10
Identities = 55/240 (22%), Positives = 96/240 (39%), Gaps = 27/240 (11%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HYGQS + N+ F LF++EM+LK+ + Y +N FD +V+ SI++
Sbjct: 1239 QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDI 1298
Query: 1657 VLVYFDLMKP--------------LGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXX 1794
+ + + + ++ R R++R+ K+
Sbjct: 1299 AITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQ 1358
Query: 1795 XXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDW 1974
GMQVFG + + NF TF QA+L +F+ TGE W
Sbjct: 1359 ALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAW 1418
Query: 1975 NTVMYHGI-------ESFGGVGTLGVIVC------IYYIVLFICGNYILLNVFLAIAVDN 2115
+M + ES T G C Y+I ++ ++++N+F+A+ +DN
Sbjct: 1419 QDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDN 1478
Score = 41.2 bits (95), Expect = 0.29
Identities = 46/240 (19%), Positives = 87/240 (36%), Gaps = 38/240 (15%)
Frame = +1
Query: 1504 DHFQTMANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYF 1671
+H ++ F +F++E+ LKM + G ++ + FN D VV S++ F +
Sbjct: 930 NHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS 989
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+ V +LR R+LR +
Sbjct: 990 AINV---VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACI 1046
Query: 1852 GMQVFGGKFNFNPQQPK------------------------PRA------NFDTFVQALL 1941
G+Q+F GK K PR+ +FD + A++
Sbjct: 1047 GVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMM 1106
Query: 1942 TVFQILTGEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+F + T E W ++Y I+S G + V + I++I+ I + ++N+F+ +
Sbjct: 1107 ALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1166
>gi|509068|emb|CAA84345.1| voltage-dependent L-type Ca channel alpha 1
subunit [Homo sapiens]
Length = 2127
Score = 1025 bits (2651), Expect = 0.0
Identities = 510/819 (62%), Positives = 638/819 (77%), Gaps = 1/819 (0%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPR +SE+ P+P+AS+ FI S N FR+ C+ +VN + FTN +LF IL+SS L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP+Q S RN IL DY FTS+FT+EI LK+ +G HKGSFCRN FN+LD+LVV
Sbjct: 918 AAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVV 977
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
+VSL SF +++ A++ AINRAKGLKHVVQCV VA++TIGNI++VT
Sbjct: 978 SVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 1037
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG + C+D SK TEAEC+G YI Y+DG+ P+ + R W N+ F+
Sbjct: 1038 LLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFD 1097
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP+LLY +IDS+ EDKGPI+N R +++
Sbjct: 1098 FDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFM 1157
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N+ QY+VW+ V
Sbjct: 1158 MNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVN 1217
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S F+ +++ N++FTG+F E +LK++A PK+
Sbjct: 1218 STYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKH 1277
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGGTNL-ISINFFRLFRVMRLVKLLSRGEGIRT 3702
Y D WN FD L+VVGS +DI ++N N ISI FFRLFRVMRLVKLLSRGEGIRT
Sbjct: 1278 YFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEGIRT 1337
Query: 3703 LLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILV 3882
LLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL+D+T I+RNNNF +FP A+L+
Sbjct: 1338 LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLL 1397
Query: 3883 LFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSF 4062
LFR ATGEAWQDIML+C + +C P S+ + E+ CG++FA YFISF+MLC+F
Sbjct: 1398 LFRCATGEAWQDIMLACMPGK--KCAPESEPSNSTE-GETPCGSSFAVFYFISFYMLCAF 1454
Query: 4063 LVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKIS 4242
L+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+W+EYDP+AKGRIKHLDVVTLLR+I
Sbjct: 1455 LIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQ 1514
Query: 4243 PPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNIDEANEQL 4422
PPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFALVRT L+I TEGN+++ANE+L
Sbjct: 1515 PPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEEL 1574
Query: 4423 RSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEMEAKGVLP 4602
R+ IK+IWKRT LLD+VVPPAG +D+VTVGKFYATFLIQ+YFR+FKKRKE G P
Sbjct: 1575 RAIIKKIWKRTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQEYFRKFKKRKEQGLVG-KP 1632
Query: 4603 AQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDE 4719
+Q A++LQAGLRTLH+IGPE++RAISG+L + D+
Sbjct: 1633 SQR-NALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDK 1670
Score = 722 bits (1863), Expect = 0.0
Identities = 383/698 (54%), Positives = 459/698 (64%), Gaps = 28/698 (4%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXX-XXXNNPIRKLCISIVEWKPFEFLILFMICANCIA 312
+KR KP +Q + NPIR+ CISIVEWKPFE +IL I ANC+A
Sbjct: 81 RKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVA 140
Query: 313 LAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDF 492
LAIY P+P DS+ N+ LE +EY+F+++FT+E LK++A G +FHP+AYLRN WN+LDF
Sbjct: 141 LAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDF 200
Query: 493 IIVVIGLVSTILSKMSIQ-----------GFDVKALRAFRVLRPLRLVSGVPSLQVVLNA 639
IIVV+GL S IL + + GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+
Sbjct: 201 IIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNS 260
Query: 640 ILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPA--TGQLAQKDPTPCGTDT 813
I++AM+PLLHIALLVLFVI+IYAIIGLELF GK+H TC + A+ DP+PC +T
Sbjct: 261 IIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALET 320
Query: 814 EGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDV 993
G +CQ + ++ G W GP +GITNFDNF AMLTVFQC+++EGWTDV
Sbjct: 321 -GHGRQCQ-NGTVCKPG----------WDGPKHGITNFDNFAFAMLTVFQCITMEGWTDV 368
Query: 994 MYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQ 1173
+YWVNDAVGR+WPWIYFVTL+I+GSFFVLNLVLGVLSGEFSKEREKA+ARG FQK REKQ
Sbjct: 369 LYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 428
Query: 1174 QLEEDLKGYLDWITQAEDIEPVNEDEQEDE--------PVAQTXXXXXXXXXXXXXXXXX 1329
QLEEDLKGYLDWITQAEDI+P NEDE DE P ++T
Sbjct: 429 QLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGEN 488
Query: 1330 XPSKWAARMKRLE------KLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQ 1491
++ A R+ + + + N VKS FYW SEHY Q
Sbjct: 489 CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQ 548
Query: 1492 SEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYF 1671
WL Q AN + LF+ EMLLKMYSLG Y S FNRFDCFVV ILE +LV
Sbjct: 549 PNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+M PLG+SVLR RLLRIFK+T+YW
Sbjct: 609 KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668
Query: 1852 GMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGV 2031
GMQ+FGGKFNF+ Q + R+ FD F Q+LLTVFQILTGEDWN+VMY GI ++GG G+
Sbjct: 669 GMQLFGGKFNFDEMQTR-RSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGM 727
Query: 2032 IVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNA 2145
+VCIY+I+LFICGNYILLNVFLAIAVDNLADA+SLT+A
Sbjct: 728 LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSA 765
Score = 131 bits (329), Expect = 2e-28
Identities = 100/342 (29%), Positives = 162/342 (47%), Gaps = 10/342 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V NN R C IV F LILF I + I+L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P Q + ++N +L +YVF +FT+E +LK+ A G H ++ RN +NILD +
Sbjct: 918 AAEDP--VQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLL 975
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S + +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 976 VVSVSLISFGIQSSAINV--VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIV 1033
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ-KDPTPCGTDTEGSAFKCQPSDSL 852
++ + ++A IG++LF GKL+ TC D + A+ K D E QP
Sbjct: 1034 IVTTLLQFMFACIGVQLFKGKLY-TCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRS-- 1090
Query: 853 TNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWP 1032
WE N +FDN AM+ +F + EGW +++Y D+ +
Sbjct: 1091 ------WE-----------NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKG 1133
Query: 1033 WIY---------FVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
IY F+ +I+ +FF++N+ +G + F ++ E+
Sbjct: 1134 PIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1175
Score = 95.9 bits (237), Expect = 1e-17
Identities = 64/259 (24%), Positives = 124/259 (47%), Gaps = 5/259 (1%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S F +++ ++ +NT+++A +HY + D N +F E +LK+ +L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD VV G ++ + + + I+ R R++R+ K+ +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL--VETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + + S +++ + LL+ L I++++GMQ F GK D+ + R + F +FP ++
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT--RRSTFDNFPQSL 696
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNF----AYPYFISF 4044
L +F+ TGE W +M D G G +F YFI
Sbjct: 697 LTVFQILTGEDWNSVMY--------------DGIMAYG------GPSFPGMLVCIYFIIL 736
Query: 4045 FMLCSFLVINLFVAVIMDN 4101
F+ +++++N+F+A+ +DN
Sbjct: 737 FICGNYILLNVFLAIAVDN 755
Score = 90.9 bits (224), Expect = 3e-16
Identities = 88/353 (24%), Positives = 148/353 (40%), Gaps = 54/353 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE +I L I N V+LA +P S L+ +F +F EA LK++A
Sbjct: 124 KPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGL 183
Query: 3511 -LNPKNYISDRWNVFD-LLVVVGSFIDITYGKLNPGGTNLIS-------INFFRLFRVMR 3663
+P Y+ + WN+ D ++VVVG F I G N + + R FRV+R
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLR 243
Query: 3664 LVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV--------- 3813
++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F GK+
Sbjct: 244 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEG 303
Query: 3814 -----ALDDSTSI------------------------HRNNNFHSFPAAILVLFRSATGE 3906
A DD + H NF +F A+L +F+ T E
Sbjct: 304 IADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITME 363
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVA 4086
W D++ +D G ++ + YF++ ++ SF V+NL +
Sbjct: 364 GWTDVLYWVND---------------------AVGRDWPWIYFVTLIIIGSFFVLNLVLG 402
Query: 4087 VIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
V+ F G + +R + + D KG +LD +T I P
Sbjct: 403 VLSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 449
Score = 89.0 bits (219), Expect = 1e-15
Identities = 77/282 (27%), Positives = 122/282 (42%), Gaps = 29/282 (10%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR--NMILNYF 2502
+L L+ N R C +V F +L I + LA P + + N L
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL----RTDAMS 2670
+Y F +FTVE LKVI +GL+FH ++ RN +NLLD ++V V L S +L + D +
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 2671 XXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
A ++ L+ V+ +I A+ + +I L+ + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 2824 AIIGVQLFKGTFF-LCNDLSKMTE-------AECRGEYIH---YEDGDPTKPVSKKRVW- 2967
AIIG++LF G C + + + + C E H ++G KP W
Sbjct: 283 AIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKP-----GWD 337
Query: 2968 --SNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEED 3087
+ NFDN AM+++F T EGW +LY D+ D
Sbjct: 338 GPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRD 379
Score = 87.0 bits (214), Expect = 5e-15
Identities = 73/304 (24%), Positives = 130/304 (42%), Gaps = 22/304 (7%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+L+ +I N I LA+ Q Y Q +K + + +F +FT+E +LK++A F
Sbjct: 1221 FEYLMFVLILLNTICLAM-QHY-GQSCLFK-IAMNILNMLFTGLFTVEMILKLIA----F 1273
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMSI----QGFDVKALRAFRVLRPLRLVSGVP 615
P Y +AWN D +IVV +V +++++ + R FRV+R ++L+S
Sbjct: 1274 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGE 1333
Query: 616 SLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPT 795
++ +L +++ L ++ALL++ + IYA+IG+++F G++A D T
Sbjct: 1334 GIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-------------GKIALNDTT 1380
Query: 796 PCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSL 975
N NF F A+L +F+C +
Sbjct: 1381 EI------------------------------------NRNNNFQTFPQAVLLLFRCATG 1404
Query: 976 EGWTDVMYWV------------------NDAVGREWPWIYFVTLVILGSFFVLNLVLGVL 1101
E W D+M G + YF++ +L +F ++NL + V+
Sbjct: 1405 EAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVI 1464
Query: 1102 SGEF 1113
F
Sbjct: 1465 MDNF 1468
Score = 74.3 bits (181), Expect = 3e-11
Identities = 55/229 (24%), Positives = 96/229 (41%), Gaps = 16/229 (6%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HYGQS + N+ F LF++EM+LK+ + Y +N FD +V+ SI++
Sbjct: 1239 QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDI 1298
Query: 1657 VLVYFDLMKP---LGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXX 1827
+ + + + ++ R R++R+ K+
Sbjct: 1299 AITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVM 1358
Query: 1828 XXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGI--- 1998
GMQVFG + + NF TF QA+L +F+ TGE W +M +
Sbjct: 1359 LFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGK 1418
Query: 1999 ----ESFGGVGTLGVIVC------IYYIVLFICGNYILLNVFLAIAVDN 2115
ES T G C Y+I ++ ++++N+F+A+ +DN
Sbjct: 1419 KCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDN 1467
Score = 43.1 bits (100), Expect = 0.077
Identities = 47/240 (19%), Positives = 88/240 (36%), Gaps = 38/240 (15%)
Frame = +1
Query: 1504 DHFQTMANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYF 1671
+H A+ F +F++E++LKM + G ++ + FN D VV S++ F +
Sbjct: 930 NHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS 989
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+ V +LR R+LR +
Sbjct: 990 AINV---VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACI 1046
Query: 1852 GMQVFGGKFNFNPQQPK------------------------PRA------NFDTFVQALL 1941
G+Q+F GK K PR+ +FD + A++
Sbjct: 1047 GVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMM 1106
Query: 1942 TVFQILTGEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+F + T E W ++Y I+S G + V + I++I+ I + ++N+F+ +
Sbjct: 1107 ALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1166
>gi|206576|gb|AAA42016.1| calcium channel alpha-1 subunit
Length = 2140
Score = 1025 bits (2650), Expect = 0.0
Identities = 511/830 (61%), Positives = 639/830 (76%), Gaps = 12/830 (1%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPR +SE+ P+P+AS+ FI S N FR+ C+ +VN + FTN +LF IL+SS L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSPNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP+Q S RN IL DY FTS+FT+EI LK+ +G HKGSFCRN FN+LD+LVV
Sbjct: 918 AAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVV 977
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
+VSL SF +++ A++ AINRAKGLKHVVQCV VA++TIGNI++VT
Sbjct: 978 SVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 1037
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG + C+D SK TEAEC+G YI Y+DG+ P+ + R W N+ F+
Sbjct: 1038 LLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFD 1097
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP+LLY +IDS+ EDKGPI+N R +++
Sbjct: 1098 FDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFM 1157
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N+ QY+VW+ V
Sbjct: 1158 MNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVN 1217
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S F+ +++ N++FTG+F E +LK++A PK
Sbjct: 1218 STYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKG 1277
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGG------------TNLISINFFRLFRVMRLV 3669
Y SD WNVFD L+V+GS ID+ + NP + ISI FFRLFRVMRLV
Sbjct: 1278 YFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMSAEENSRISITFFRLFRVMRLV 1337
Query: 3670 KLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNN 3849
KLLSRGEGIRTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL+D+T I+RNN
Sbjct: 1338 KLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNN 1397
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FP A+L+LFR ATGEAWQDIML+C + +C P S+ + E+ CG++FA
Sbjct: 1398 NFQTFPQAVLLLFRCATGEAWQDIMLACMPGK--KCAPESEPSNSTE-GETPCGSSFAVF 1454
Query: 4030 YFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKH 4209
YFISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+W+EYDP+AKGRIKH
Sbjct: 1455 YFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKH 1514
Query: 4210 LDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYT 4389
LDVVTLLR+I PPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFALVRT L+I T
Sbjct: 1515 LDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKT 1574
Query: 4390 EGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKK 4569
EGN+++ANE+LR+ IK+IWKRT LLD+VVPPAG +D+VTVGKFYATFLIQ+YFR+FKK
Sbjct: 1575 EGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQEYFRKFKK 1633
Query: 4570 RKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDE 4719
RKE G P+Q A++LQAGLRTLH+IGPE++RAISG+L + D+
Sbjct: 1634 RKEQGLVG-KPSQR-NALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDK 1681
Score = 708 bits (1827), Expect = 0.0
Identities = 372/668 (55%), Positives = 448/668 (66%), Gaps = 27/668 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR+ CISIVEWKPFE +IL I ANC+ALAIY P+P DS+ N+ LE +EY+F+++F
Sbjct: 111 NPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIF 170
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQ-----------G 549
T+E LK++A G +FHP+AYLRN WN+LDFIIVV+GL S IL + + G
Sbjct: 171 TVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAG 230
Query: 550 FDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELF 729
FDVKALRAFRVLRPLRLVSGVPSLQVVLN+I++AM+PLLHIALLVLFVI+IYAIIGLELF
Sbjct: 231 FDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELF 290
Query: 730 CGKLHSTCIDPA--TGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPG 903
GK+H TC + A++DP+PC +T G +CQ + ++ G W G
Sbjct: 291 MGKMHKTCYNQEGIIDVPAEEDPSPCALET-GHGRQCQ-NGTVCKPG----------WDG 338
Query: 904 PNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLN 1083
P +GITNFDNF AMLTVFQC+++EGWTDV+YW+ DA+G E PW+YFV+LVI GSFFVLN
Sbjct: 339 PKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLN 398
Query: 1084 LVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDE 1263
LVLGVLSGEFSKEREKA+ARG FQK REKQQLEEDLKGYLDWITQAEDI+P NEDE DE
Sbjct: 399 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDE 458
Query: 1264 --------PVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLE------KLNXXXXXXXX 1401
P ++T ++ A R+ + + + N
Sbjct: 459 DKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCR 518
Query: 1402 XLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSL 1581
VKS FYW SEHY Q WL Q AN + LF+ EMLLKMYSL
Sbjct: 519 AAVKSNVFYWLVIFLVFLNTLTIASEHYNQPHWLTEVQDTANKALLALFTAEMLLKMYSL 578
Query: 1582 GFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXX 1761
G Y S FNRFDCF+V ILE +LV +M PLG+SVLR RLLRIFK+T+YW
Sbjct: 579 GLQAYFVSLFNRFDCFIVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 1762 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALL 1941
GMQ+FGGKFNF+ Q + R+ FD F Q+LL
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTR-RSTFDNFPQSLL 697
Query: 1942 TVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLA 2121
TVFQILTGEDWN+VMY GI ++GG G++VCIY+I+LFICGNYILLNVFLAIAVDNLA
Sbjct: 698 TVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLA 757
Query: 2122 DADSLTNA 2145
DA+SLT+A
Sbjct: 758 DAESLTSA 765
Score = 130 bits (327), Expect = 4e-28
Identities = 100/342 (29%), Positives = 162/342 (47%), Gaps = 10/342 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V NN R C IV F LILF I + I+L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSPNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P Q + ++N +L +YVF +FT+E +LK+ A G H ++ RN +NILD +
Sbjct: 918 AAEDP--VQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLL 975
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S + +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 976 VVSVSLISFGIQSSAINV--VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIV 1033
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ-KDPTPCGTDTEGSAFKCQPSDSL 852
++ + ++A IG++LF GKL+ TC D + A+ K D E QP
Sbjct: 1034 IVTTLLQFMFACIGVQLFKGKLY-TCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRS-- 1090
Query: 853 TNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWP 1032
WE N +FDN AM+ +F + EGW +++Y D+ +
Sbjct: 1091 ------WE-----------NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKG 1133
Query: 1033 WIY---------FVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
IY F+ +I+ +FF++N+ +G + F ++ E+
Sbjct: 1134 PIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1175
Score = 95.5 bits (236), Expect = 1e-17
Identities = 63/259 (24%), Positives = 124/259 (47%), Gaps = 5/259 (1%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S F +++ ++ +NT+++A +HY + D N +F E +LK+ +L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPHWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD +V G ++ + + + I+ R R++R+ K+ +
Sbjct: 581 QAYFVSLFNRFDCFIVCGGILETIL--VETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + + S +++ + LL+ L I++++GMQ F GK D+ + R + F +FP ++
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT--RRSTFDNFPQSL 696
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNF----AYPYFISF 4044
L +F+ TGE W +M D G G +F YFI
Sbjct: 697 LTVFQILTGEDWNSVMY--------------DGIMAYG------GPSFPGMLVCIYFIIL 736
Query: 4045 FMLCSFLVINLFVAVIMDN 4101
F+ +++++N+F+A+ +DN
Sbjct: 737 FICGNYILLNVFLAIAVDN 755
Score = 90.5 bits (223), Expect = 4e-16
Identities = 76/315 (24%), Positives = 133/315 (42%), Gaps = 33/315 (10%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+L+ +I N I LA+ Q Y Q +K + + +F +FT+E +LK++A F
Sbjct: 1221 FEYLMFVLILLNTICLAM-QHY-GQSCLFK-IAMNILNMLFTGLFTVEMILKLIA----F 1273
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSK------------MSIQG---FDVKALRAFRV 582
P Y + WN+ DF+IV+ ++ ILS+ MS + + R FRV
Sbjct: 1274 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMSAEENSRISITFFRLFRV 1333
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
+R ++L+S ++ +L +++ L ++ALL++ + IYA+IG+++F
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF----------- 1382
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
G++A D T N NF F
Sbjct: 1383 --GKIALNDTTEI------------------------------------NRNNNFQTFPQ 1404
Query: 943 AMLTVFQCVSLEGWTDVMYWV------------------NDAVGREWPWIYFVTLVILGS 1068
A+L +F+C + E W D+M G + YF++ +L +
Sbjct: 1405 AVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCA 1464
Query: 1069 FFVLNLVLGVLSGEF 1113
F ++NL + V+ F
Sbjct: 1465 FLIINLFVAVIMDNF 1479
Score = 87.8 bits (216), Expect = 3e-15
Identities = 74/273 (27%), Positives = 119/273 (43%), Gaps = 29/273 (10%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR--NMILNYF 2502
+L L+ N R C +V F +L I + LA P + + N L
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL----RTDAMS 2670
+Y F +FTVE LKVI +GL+FH ++ RN +NLLD ++V V L S +L + D +
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 2671 XXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
A ++ L+ V+ +I A+ + +I L+ + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 2824 AIIGVQLFKGTFF--------LCNDLSKMTEAECRGEYIH---YEDGDPTKPVSKKRVW- 2967
AIIG++LF G + + ++ + C E H ++G KP W
Sbjct: 283 AIIGLELFMGKMHKTCYNQEGIIDVPAEEDPSPCALETGHGRQCQNGTVCKP-----GWD 337
Query: 2968 --SNNDFNFDNVGDAMISLFVVSTFEGWPQLLY 3060
+ NFDN AM+++F T EGW +LY
Sbjct: 338 GPKHGITNFDNFAFAMLTVFQCITMEGWTDVLY 370
Score = 87.8 bits (216), Expect = 3e-15
Identities = 88/353 (24%), Positives = 144/353 (39%), Gaps = 54/353 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE +I L I N V+LA +P S L+ +F +F EA LK++A
Sbjct: 124 KPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGL 183
Query: 3511 -LNPKNYISDRWNVFD-LLVVVGSFIDITYGKLNPGGTNLIS-------INFFRLFRVMR 3663
+P Y+ + WN+ D ++VVVG F I G N + + R FRV+R
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLR 243
Query: 3664 LVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV--------- 3813
++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F GK+
Sbjct: 244 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEG 303
Query: 3814 -----ALDDSTSI------------------------HRNNNFHSFPAAILVLFRSATGE 3906
A +D + H NF +F A+L +F+ T E
Sbjct: 304 IIDVPAEEDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITME 363
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVA 4086
W D++ D G + YF+S + SF V+NL +
Sbjct: 364 GWTDVLYWMQD---------------------AMGYELPWVYFVSLVIFGSFFVLNLVLG 402
Query: 4087 VIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
V+ F G + +R + + D KG +LD +T I P
Sbjct: 403 VLSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 449
Score = 70.9 bits (172), Expect = 3e-10
Identities = 57/240 (23%), Positives = 98/240 (40%), Gaps = 27/240 (11%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HYGQS + N+ F LF++EM+LK+ + Y + +N FD +VI SI++
Sbjct: 1239 QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDV 1298
Query: 1657 VL--------------VYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXX 1794
+L + + + ++ R R++R+ K+
Sbjct: 1299 ILSETNPAEHTQCSPSMSAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQ 1358
Query: 1795 XXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDW 1974
GMQVFG + + NF TF QA+L +F+ TGE W
Sbjct: 1359 ALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAW 1418
Query: 1975 NTVMYHGI-------ESFGGVGTLGVIVC------IYYIVLFICGNYILLNVFLAIAVDN 2115
+M + ES T G C Y+I ++ ++++N+F+A+ +DN
Sbjct: 1419 QDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDN 1478
Score = 43.1 bits (100), Expect = 0.077
Identities = 47/240 (19%), Positives = 88/240 (36%), Gaps = 38/240 (15%)
Frame = +1
Query: 1504 DHFQTMANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYF 1671
+H A+ F +F++E++LKM + G ++ + FN D VV S++ F +
Sbjct: 930 NHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS 989
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+ V +LR R+LR +
Sbjct: 990 AINV---VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACI 1046
Query: 1852 GMQVFGGKFNFNPQQPK------------------------PRA------NFDTFVQALL 1941
G+Q+F GK K PR+ +FD + A++
Sbjct: 1047 GVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMM 1106
Query: 1942 TVFQILTGEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+F + T E W ++Y I+S G + V + I++I+ I + ++N+F+ +
Sbjct: 1107 ALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1166
>gi|17864840|gb|AAL47073.1| L-type calcium channel alpha-1c subunit
[Rattus norvegicus]
Length = 2170
Score = 1025 bits (2650), Expect = 0.0
Identities = 511/830 (61%), Positives = 639/830 (76%), Gaps = 12/830 (1%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPR +SE+ P+P+AS+ FI S N FR+ C+ +VN + FTN +LF IL+SS L
Sbjct: 888 RPRPLSELHLKEKAVPMPEASAFFIFSPNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 947
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP+Q S RN IL DY FTS+FT+EI LK+ +G HKGSFCRN FN+LD+LVV
Sbjct: 948 AAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVV 1007
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
+VSL SF +++ A++ AINRAKGLKHVVQCV VA++TIGNI++VT
Sbjct: 1008 SVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 1067
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG + C+D SK TEAEC+G YI Y+DG+ P+ + R W N+ F+
Sbjct: 1068 LLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFD 1127
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP+LLY +IDS+ EDKGPI+N R +++
Sbjct: 1128 FDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFM 1187
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N+ QY+VW+ V
Sbjct: 1188 MNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVN 1247
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S F+ +++ N++FTG+F E +LK++A PK
Sbjct: 1248 STYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKG 1307
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGG------------TNLISINFFRLFRVMRLV 3669
Y SD WNVFD L+V+GS ID+ + NP + ISI FFRLFRVMRLV
Sbjct: 1308 YFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMSAEENSRISITFFRLFRVMRLV 1367
Query: 3670 KLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNN 3849
KLLSRGEGIRTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL+D+T I+RNN
Sbjct: 1368 KLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNN 1427
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FP A+L+LFR ATGEAWQDIML+C + +C P S+ + E+ CG++FA
Sbjct: 1428 NFQTFPQAVLLLFRCATGEAWQDIMLACMPGK--KCAPESEPSNSTE-GETPCGSSFAVF 1484
Query: 4030 YFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKH 4209
YFISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+W+EYDP+AKGRIKH
Sbjct: 1485 YFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKH 1544
Query: 4210 LDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYT 4389
LDVVTLLR+I PPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFALVRT L+I T
Sbjct: 1545 LDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKT 1604
Query: 4390 EGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKK 4569
EGN+++ANE+LR+ IK+IWKRT LLD+VVPPAG +D+VTVGKFYATFLIQ+YFR+FKK
Sbjct: 1605 EGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQEYFRKFKK 1663
Query: 4570 RKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDE 4719
RKE G P+Q A++LQAGLRTLH+IGPE++RAISG+L + D+
Sbjct: 1664 RKEQGLVG-KPSQR-NALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDK 1711
Score = 708 bits (1827), Expect = 0.0
Identities = 372/668 (55%), Positives = 448/668 (66%), Gaps = 27/668 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR+ CISIVEWKPFE +IL I ANC+ALAIY P+P DS+ N+ LE +EY+F+++F
Sbjct: 141 NPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIF 200
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQ-----------G 549
T+E LK++A G +FHP+AYLRN WN+LDFIIVV+GL S IL + + G
Sbjct: 201 TVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAG 260
Query: 550 FDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELF 729
FDVKALRAFRVLRPLRLVSGVPSLQVVLN+I++AM+PLLHIALLVLFVI+IYAIIGLELF
Sbjct: 261 FDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELF 320
Query: 730 CGKLHSTCIDPA--TGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPG 903
GK+H TC + A++DP+PC +T G +CQ + ++ G W G
Sbjct: 321 MGKMHKTCYNQEGIIDVPAEEDPSPCALET-GHGRQCQ-NGTVCKPG----------WDG 368
Query: 904 PNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLN 1083
P +GITNFDNF AMLTVFQC+++EGWTDV+YW+ DA+G E PW+YFV+LVI GSFFVLN
Sbjct: 369 PKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLN 428
Query: 1084 LVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDE 1263
LVLGVLSGEFSKEREKA+ARG FQK REKQQLEEDLKGYLDWITQAEDI+P NEDE DE
Sbjct: 429 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDE 488
Query: 1264 --------PVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLE------KLNXXXXXXXX 1401
P ++T ++ A R+ + + + N
Sbjct: 489 DKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCR 548
Query: 1402 XLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSL 1581
VKS FYW SEHY Q WL Q AN + LF+ EMLLKMYSL
Sbjct: 549 AAVKSNVFYWLVIFLVFLNTLTIASEHYNQPHWLTEVQDTANKALLALFTAEMLLKMYSL 608
Query: 1582 GFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXX 1761
G Y S FNRFDCF+V ILE +LV +M PLG+SVLR RLLRIFK+T+YW
Sbjct: 609 GLQAYFVSLFNRFDCFIVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 668
Query: 1762 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALL 1941
GMQ+FGGKFNF+ Q + R+ FD F Q+LL
Sbjct: 669 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTR-RSTFDNFPQSLL 727
Query: 1942 TVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLA 2121
TVFQILTGEDWN+VMY GI ++GG G++VCIY+I+LFICGNYILLNVFLAIAVDNLA
Sbjct: 728 TVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLA 787
Query: 2122 DADSLTNA 2145
DA+SLT+A
Sbjct: 788 DAESLTSA 795
Score = 130 bits (327), Expect = 4e-28
Identities = 100/342 (29%), Positives = 162/342 (47%), Gaps = 10/342 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V NN R C IV F LILF I + I+L
Sbjct: 888 RPRPLSELHLKEKAVPMPEASAFFIFSPNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 947
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P Q + ++N +L +YVF +FT+E +LK+ A G H ++ RN +NILD +
Sbjct: 948 AAEDP--VQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLL 1005
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S + +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 1006 VVSVSLISFGIQSSAINV--VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIV 1063
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ-KDPTPCGTDTEGSAFKCQPSDSL 852
++ + ++A IG++LF GKL+ TC D + A+ K D E QP
Sbjct: 1064 IVTTLLQFMFACIGVQLFKGKLY-TCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRS-- 1120
Query: 853 TNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWP 1032
WE N +FDN AM+ +F + EGW +++Y D+ +
Sbjct: 1121 ------WE-----------NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKG 1163
Query: 1033 WIY---------FVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
IY F+ +I+ +FF++N+ +G + F ++ E+
Sbjct: 1164 PIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1205
Score = 95.5 bits (236), Expect = 1e-17
Identities = 63/259 (24%), Positives = 124/259 (47%), Gaps = 5/259 (1%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S F +++ ++ +NT+++A +HY + D N +F E +LK+ +L
Sbjct: 551 VKSNVFYWLVIFLVFLNTLTIASEHYNQPHWLTEVQDTANKALLALFTAEMLLKMYSLGL 610
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD +V G ++ + + + I+ R R++R+ K+ +
Sbjct: 611 QAYFVSLFNRFDCFIVCGGILETIL--VETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 668
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + + S +++ + LL+ L I++++GMQ F GK D+ + R + F +FP ++
Sbjct: 669 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT--RRSTFDNFPQSL 726
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNF----AYPYFISF 4044
L +F+ TGE W +M D G G +F YFI
Sbjct: 727 LTVFQILTGEDWNSVMY--------------DGIMAYG------GPSFPGMLVCIYFIIL 766
Query: 4045 FMLCSFLVINLFVAVIMDN 4101
F+ +++++N+F+A+ +DN
Sbjct: 767 FICGNYILLNVFLAIAVDN 785
Score = 90.5 bits (223), Expect = 4e-16
Identities = 76/315 (24%), Positives = 133/315 (42%), Gaps = 33/315 (10%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+L+ +I N I LA+ Q Y Q +K + + +F +FT+E +LK++A F
Sbjct: 1251 FEYLMFVLILLNTICLAM-QHY-GQSCLFK-IAMNILNMLFTGLFTVEMILKLIA----F 1303
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSK------------MSIQG---FDVKALRAFRV 582
P Y + WN+ DF+IV+ ++ ILS+ MS + + R FRV
Sbjct: 1304 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMSAEENSRISITFFRLFRV 1363
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
+R ++L+S ++ +L +++ L ++ALL++ + IYA+IG+++F
Sbjct: 1364 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF----------- 1412
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
G++A D T N NF F
Sbjct: 1413 --GKIALNDTTEI------------------------------------NRNNNFQTFPQ 1434
Query: 943 AMLTVFQCVSLEGWTDVMYWV------------------NDAVGREWPWIYFVTLVILGS 1068
A+L +F+C + E W D+M G + YF++ +L +
Sbjct: 1435 AVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCA 1494
Query: 1069 FFVLNLVLGVLSGEF 1113
F ++NL + V+ F
Sbjct: 1495 FLIINLFVAVIMDNF 1509
Score = 87.8 bits (216), Expect = 3e-15
Identities = 74/273 (27%), Positives = 119/273 (43%), Gaps = 29/273 (10%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR--NMILNYF 2502
+L L+ N R C +V F +L I + LA P + + N L
Sbjct: 133 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 192
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL----RTDAMS 2670
+Y F +FTVE LKVI +GL+FH ++ RN +NLLD ++V V L S +L + D +
Sbjct: 193 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 252
Query: 2671 XXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
A ++ L+ V+ +I A+ + +I L+ + ++
Sbjct: 253 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 312
Query: 2824 AIIGVQLFKGTFF--------LCNDLSKMTEAECRGEYIH---YEDGDPTKPVSKKRVW- 2967
AIIG++LF G + + ++ + C E H ++G KP W
Sbjct: 313 AIIGLELFMGKMHKTCYNQEGIIDVPAEEDPSPCALETGHGRQCQNGTVCKP-----GWD 367
Query: 2968 --SNNDFNFDNVGDAMISLFVVSTFEGWPQLLY 3060
+ NFDN AM+++F T EGW +LY
Sbjct: 368 GPKHGITNFDNFAFAMLTVFQCITMEGWTDVLY 400
Score = 87.8 bits (216), Expect = 3e-15
Identities = 88/353 (24%), Positives = 144/353 (39%), Gaps = 54/353 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE +I L I N V+LA +P S L+ +F +F EA LK++A
Sbjct: 154 KPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGL 213
Query: 3511 -LNPKNYISDRWNVFD-LLVVVGSFIDITYGKLNPGGTNLIS-------INFFRLFRVMR 3663
+P Y+ + WN+ D ++VVVG F I G N + + R FRV+R
Sbjct: 214 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLR 273
Query: 3664 LVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV--------- 3813
++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F GK+
Sbjct: 274 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEG 333
Query: 3814 -----ALDDSTSI------------------------HRNNNFHSFPAAILVLFRSATGE 3906
A +D + H NF +F A+L +F+ T E
Sbjct: 334 IIDVPAEEDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITME 393
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVA 4086
W D++ D G + YF+S + SF V+NL +
Sbjct: 394 GWTDVLYWMQD---------------------AMGYELPWVYFVSLVIFGSFFVLNLVLG 432
Query: 4087 VIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
V+ F G + +R + + D KG +LD +T I P
Sbjct: 433 VLSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 479
Score = 70.9 bits (172), Expect = 3e-10
Identities = 57/240 (23%), Positives = 98/240 (40%), Gaps = 27/240 (11%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HYGQS + N+ F LF++EM+LK+ + Y + +N FD +VI SI++
Sbjct: 1269 QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDV 1328
Query: 1657 VL--------------VYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXX 1794
+L + + + ++ R R++R+ K+
Sbjct: 1329 ILSETNPAEHTQCSPSMSAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQ 1388
Query: 1795 XXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDW 1974
GMQVFG + + NF TF QA+L +F+ TGE W
Sbjct: 1389 ALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAW 1448
Query: 1975 NTVMYHGI-------ESFGGVGTLGVIVC------IYYIVLFICGNYILLNVFLAIAVDN 2115
+M + ES T G C Y+I ++ ++++N+F+A+ +DN
Sbjct: 1449 QDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDN 1508
Score = 43.1 bits (100), Expect = 0.077
Identities = 47/240 (19%), Positives = 88/240 (36%), Gaps = 38/240 (15%)
Frame = +1
Query: 1504 DHFQTMANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYF 1671
+H A+ F +F++E++LKM + G ++ + FN D VV S++ F +
Sbjct: 960 NHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS 1019
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+ V +LR R+LR +
Sbjct: 1020 AINV---VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACI 1076
Query: 1852 GMQVFGGKFNFNPQQPK------------------------PRA------NFDTFVQALL 1941
G+Q+F GK K PR+ +FD + A++
Sbjct: 1077 GVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMM 1136
Query: 1942 TVFQILTGEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+F + T E W ++Y I+S G + V + I++I+ I + ++N+F+ +
Sbjct: 1137 ALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1196
>gi|6753228|ref|NP_033911.1| calcium channel, voltage-dependent, L
type, alpha 1C subunit; (alpha)1 subunit [Mus musculus]
gi|6165982|sp|Q01815|CCAC_MOUSE Voltage-dependent L-type calcium
channel alpha-1C subunit (Voltage-gated calcium channel
alpha subunit Cav1.2) (Calcium channel, L type, alpha-1
polypeptide, isoform 1, cardiac muscle) (Mouse brain
class C) (MBC) (MELC-CC)
gi|346902|pir||A44467 voltage-dependent calcium channel complex
alpha-1 chain mbC - mouse
gi|192960|gb|AAB59633.1| L-type calcium channel alpha-1
Length = 2139
Score = 1025 bits (2650), Expect = 0.0
Identities = 511/830 (61%), Positives = 639/830 (76%), Gaps = 12/830 (1%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPR +SE+ P+P+AS+ FI S N FR+ C+ +VN + FTN +LF IL+SS L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSPNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP+Q S RN IL DY FTS+FT+EI LK+ +G HKGSFCRN FN+LD+LVV
Sbjct: 918 AAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVV 977
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
+VSL SF +++ A++ AINRAKGLKHVVQCV VA++TIGNI++VT
Sbjct: 978 SVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 1037
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG + C+D SK TEAEC+G YI Y+DG+ P+ + R W N+ F+
Sbjct: 1038 LLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFD 1097
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP+LLY +IDS+ EDKGPI+N R +++
Sbjct: 1098 FDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFM 1157
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N+ QY+VW+ V
Sbjct: 1158 MNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVN 1217
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S F+ +++ N++FTG+F E +LK++A PK
Sbjct: 1218 STYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKG 1277
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGG------------TNLISINFFRLFRVMRLV 3669
Y SD WNVFD L+V+GS ID+ + NP + ISI FFRLFRVMRLV
Sbjct: 1278 YFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMSAEENSRISITFFRLFRVMRLV 1337
Query: 3670 KLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNN 3849
KLLSRGEGIRTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL+D+T I+RNN
Sbjct: 1338 KLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNN 1397
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FP A+L+LFR ATGEAWQDIML+C + +C P S+ + E+ CG++FA
Sbjct: 1398 NFQTFPQAVLLLFRCATGEAWQDIMLACMPGK--KCAPESEPSNSTE-GETPCGSSFAVF 1454
Query: 4030 YFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKH 4209
YFISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+W+EYDP+AKGRIKH
Sbjct: 1455 YFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKH 1514
Query: 4210 LDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYT 4389
LDVVTLLR+I PPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFALVRT L+I T
Sbjct: 1515 LDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKT 1574
Query: 4390 EGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKK 4569
EGN+++ANE+LR+ IK+IWKRT LLD+VVPPAG +D+VTVGKFYATFLIQ+YFR+FKK
Sbjct: 1575 EGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQEYFRKFKK 1633
Query: 4570 RKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDE 4719
RKE G P+Q A++LQAGLRTLH+IGPE++RAISG+L + D+
Sbjct: 1634 RKEQGLVG-KPSQR-NALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDK 1681
Score = 708 bits (1827), Expect = 0.0
Identities = 372/668 (55%), Positives = 448/668 (66%), Gaps = 27/668 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR+ CISIVEWKPFE +IL I ANC+ALAIY P+P DS+ N+ LE +EY+F+++F
Sbjct: 111 NPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIF 170
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQ-----------G 549
T+E LK++A G +FHP+AYLRN WN+LDFIIVV+GL S IL + + G
Sbjct: 171 TVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAG 230
Query: 550 FDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELF 729
FDVKALRAFRVLRPLRLVSGVPSLQVVLN+I++AM+PLLHIALLVLFVI+IYAIIGLELF
Sbjct: 231 FDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELF 290
Query: 730 CGKLHSTCIDPA--TGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPG 903
GK+H TC + A++DP+PC +T G +CQ + ++ G W G
Sbjct: 291 MGKMHKTCYNQEGIIDVPAEEDPSPCALET-GHGRQCQ-NGTVCKPG----------WDG 338
Query: 904 PNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLN 1083
P +GITNFDNF AMLTVFQC+++EGWTDV+YW+ DA+G E PW+YFV+LVI GSFFVLN
Sbjct: 339 PKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLN 398
Query: 1084 LVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDE 1263
LVLGVLSGEFSKEREKA+ARG FQK REKQQLEEDLKGYLDWITQAEDI+P NEDE DE
Sbjct: 399 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDE 458
Query: 1264 --------PVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLE------KLNXXXXXXXX 1401
P ++T ++ A R+ + + + N
Sbjct: 459 DKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCR 518
Query: 1402 XLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSL 1581
VKS FYW SEHY Q WL Q AN + LF+ EMLLKMYSL
Sbjct: 519 AAVKSNVFYWLVIFLVFLNTLTIASEHYNQPHWLTEVQDTANKALLALFTAEMLLKMYSL 578
Query: 1582 GFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXX 1761
G Y S FNRFDCF+V ILE +LV +M PLG+SVLR RLLRIFK+T+YW
Sbjct: 579 GLQAYFVSLFNRFDCFIVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 1762 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALL 1941
GMQ+FGGKFNF+ Q + R+ FD F Q+LL
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTR-RSTFDNFPQSLL 697
Query: 1942 TVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLA 2121
TVFQILTGEDWN+VMY GI ++GG G++VCIY+I+LFICGNYILLNVFLAIAVDNLA
Sbjct: 698 TVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLA 757
Query: 2122 DADSLTNA 2145
DA+SLT+A
Sbjct: 758 DAESLTSA 765
Score = 130 bits (327), Expect = 4e-28
Identities = 100/342 (29%), Positives = 162/342 (47%), Gaps = 10/342 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V NN R C IV F LILF I + I+L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSPNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P Q + ++N +L +YVF +FT+E +LK+ A G H ++ RN +NILD +
Sbjct: 918 AAEDP--VQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLL 975
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S + +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 976 VVSVSLISFGIQSSAINV--VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIV 1033
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ-KDPTPCGTDTEGSAFKCQPSDSL 852
++ + ++A IG++LF GKL+ TC D + A+ K D E QP
Sbjct: 1034 IVTTLLQFMFACIGVQLFKGKLY-TCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRS-- 1090
Query: 853 TNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWP 1032
WE N +FDN AM+ +F + EGW +++Y D+ +
Sbjct: 1091 ------WE-----------NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKG 1133
Query: 1033 WIY---------FVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
IY F+ +I+ +FF++N+ +G + F ++ E+
Sbjct: 1134 PIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1175
Score = 95.5 bits (236), Expect = 1e-17
Identities = 63/259 (24%), Positives = 124/259 (47%), Gaps = 5/259 (1%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S F +++ ++ +NT+++A +HY + D N +F E +LK+ +L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPHWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD +V G ++ + + + I+ R R++R+ K+ +
Sbjct: 581 QAYFVSLFNRFDCFIVCGGILETIL--VETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + + S +++ + LL+ L I++++GMQ F GK D+ + R + F +FP ++
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT--RRSTFDNFPQSL 696
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNF----AYPYFISF 4044
L +F+ TGE W +M D G G +F YFI
Sbjct: 697 LTVFQILTGEDWNSVMY--------------DGIMAYG------GPSFPGMLVCIYFIIL 736
Query: 4045 FMLCSFLVINLFVAVIMDN 4101
F+ +++++N+F+A+ +DN
Sbjct: 737 FICGNYILLNVFLAIAVDN 755
Score = 90.5 bits (223), Expect = 4e-16
Identities = 76/315 (24%), Positives = 133/315 (42%), Gaps = 33/315 (10%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+L+ +I N I LA+ Q Y Q +K + + +F +FT+E +LK++A F
Sbjct: 1221 FEYLMFVLILLNTICLAM-QHY-GQSCLFK-IAMNILNMLFTGLFTVEMILKLIA----F 1273
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSK------------MSIQG---FDVKALRAFRV 582
P Y + WN+ DF+IV+ ++ ILS+ MS + + R FRV
Sbjct: 1274 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMSAEENSRISITFFRLFRV 1333
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
+R ++L+S ++ +L +++ L ++ALL++ + IYA+IG+++F
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF----------- 1382
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
G++A D T N NF F
Sbjct: 1383 --GKIALNDTTEI------------------------------------NRNNNFQTFPQ 1404
Query: 943 AMLTVFQCVSLEGWTDVMYWV------------------NDAVGREWPWIYFVTLVILGS 1068
A+L +F+C + E W D+M G + YF++ +L +
Sbjct: 1405 AVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCA 1464
Query: 1069 FFVLNLVLGVLSGEF 1113
F ++NL + V+ F
Sbjct: 1465 FLIINLFVAVIMDNF 1479
Score = 87.8 bits (216), Expect = 3e-15
Identities = 74/273 (27%), Positives = 119/273 (43%), Gaps = 29/273 (10%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR--NMILNYF 2502
+L L+ N R C +V F +L I + LA P + + N L
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL----RTDAMS 2670
+Y F +FTVE LKVI +GL+FH ++ RN +NLLD ++V V L S +L + D +
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 2671 XXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
A ++ L+ V+ +I A+ + +I L+ + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 2824 AIIGVQLFKGTFF--------LCNDLSKMTEAECRGEYIH---YEDGDPTKPVSKKRVW- 2967
AIIG++LF G + + ++ + C E H ++G KP W
Sbjct: 283 AIIGLELFMGKMHKTCYNQEGIIDVPAEEDPSPCALETGHGRQCQNGTVCKP-----GWD 337
Query: 2968 --SNNDFNFDNVGDAMISLFVVSTFEGWPQLLY 3060
+ NFDN AM+++F T EGW +LY
Sbjct: 338 GPKHGITNFDNFAFAMLTVFQCITMEGWTDVLY 370
Score = 87.8 bits (216), Expect = 3e-15
Identities = 88/353 (24%), Positives = 144/353 (39%), Gaps = 54/353 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE +I L I N V+LA +P S L+ +F +F EA LK++A
Sbjct: 124 KPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGL 183
Query: 3511 -LNPKNYISDRWNVFD-LLVVVGSFIDITYGKLNPGGTNLIS-------INFFRLFRVMR 3663
+P Y+ + WN+ D ++VVVG F I G N + + R FRV+R
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLR 243
Query: 3664 LVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV--------- 3813
++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F GK+
Sbjct: 244 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEG 303
Query: 3814 -----ALDDSTSI------------------------HRNNNFHSFPAAILVLFRSATGE 3906
A +D + H NF +F A+L +F+ T E
Sbjct: 304 IIDVPAEEDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITME 363
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVA 4086
W D++ D G + YF+S + SF V+NL +
Sbjct: 364 GWTDVLYWMQD---------------------AMGYELPWVYFVSLVIFGSFFVLNLVLG 402
Query: 4087 VIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
V+ F G + +R + + D KG +LD +T I P
Sbjct: 403 VLSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 449
Score = 70.9 bits (172), Expect = 3e-10
Identities = 57/240 (23%), Positives = 98/240 (40%), Gaps = 27/240 (11%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HYGQS + N+ F LF++EM+LK+ + Y + +N FD +VI SI++
Sbjct: 1239 QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDV 1298
Query: 1657 VL--------------VYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXX 1794
+L + + + ++ R R++R+ K+
Sbjct: 1299 ILSETNPAEHTQCSPSMSAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQ 1358
Query: 1795 XXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDW 1974
GMQVFG + + NF TF QA+L +F+ TGE W
Sbjct: 1359 ALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAW 1418
Query: 1975 NTVMYHGI-------ESFGGVGTLGVIVC------IYYIVLFICGNYILLNVFLAIAVDN 2115
+M + ES T G C Y+I ++ ++++N+F+A+ +DN
Sbjct: 1419 QDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDN 1478
Score = 43.1 bits (100), Expect = 0.077
Identities = 47/240 (19%), Positives = 88/240 (36%), Gaps = 38/240 (15%)
Frame = +1
Query: 1504 DHFQTMANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYF 1671
+H A+ F +F++E++LKM + G ++ + FN D VV S++ F +
Sbjct: 930 NHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS 989
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+ V +LR R+LR +
Sbjct: 990 AINV---VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACI 1046
Query: 1852 GMQVFGGKFNFNPQQPK------------------------PRA------NFDTFVQALL 1941
G+Q+F GK K PR+ +FD + A++
Sbjct: 1047 GVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMM 1106
Query: 1942 TVFQILTGEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+F + T E W ++Y I+S G + V + I++I+ I + ++N+F+ +
Sbjct: 1107 ALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1166
>gi|509178|emb|CAA84353.1| voltage-dependent L-type Ca channel alpha 1
subunit [Homo sapiens]
Length = 2173
Score = 1023 bits (2645), Expect = 0.0
Identities = 510/830 (61%), Positives = 639/830 (76%), Gaps = 12/830 (1%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPR +SE+ P+P+AS+ FI S N FR+ C+ +VN + FTN +LF IL+SS L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP+Q S RN IL DY FTS+FT+EI LK+ +G HKGSFCRN FN+LD+LVV
Sbjct: 918 AAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVV 977
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
+VSL SF +++ A++ AINRAKGLKHVVQCV VA++TIGNI++VT
Sbjct: 978 SVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 1037
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG + C+D SK TEAEC+G YI Y+DG+ P+ + R W N+ F+
Sbjct: 1038 LLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFD 1097
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP+LLY +IDS+ EDKGPI+N R +++
Sbjct: 1098 FDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFM 1157
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N+ QY+VW+ V
Sbjct: 1158 MNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVN 1217
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S F+ +++ N++FTG+F E +LK++A PK+
Sbjct: 1218 STYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKH 1277
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGG------------TNLISINFFRLFRVMRLV 3669
Y D WN FD L+VVGS +DI ++NP + ISI FFRLFRVMRLV
Sbjct: 1278 YFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLV 1337
Query: 3670 KLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNN 3849
KLLSRGEGIRTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL+D+T I+RNN
Sbjct: 1338 KLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNN 1397
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FP A+L+LFR ATGEAWQDIML+C + +C P S+ + E+ CG++FA
Sbjct: 1398 NFQTFPQAVLLLFRCATGEAWQDIMLACMPGK--KCAPESEPSNSTE-GETPCGSSFAVF 1454
Query: 4030 YFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKH 4209
YFISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+W+EYDP+AKGRIKH
Sbjct: 1455 YFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKH 1514
Query: 4210 LDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYT 4389
LDVVTLLR+I PPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFALVRT L+I T
Sbjct: 1515 LDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKT 1574
Query: 4390 EGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKK 4569
EGN+++ANE+LR+ IK+IWKRT LLD+VVPPAG +D+VTVGKFYATFLIQ+YFR+FKK
Sbjct: 1575 EGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQEYFRKFKK 1633
Query: 4570 RKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDE 4719
RKE G P+Q A++LQAGLRTLH+IGPE++RAISG+L + D+
Sbjct: 1634 RKEQGLVG-KPSQR-NALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDK 1681
Score = 722 bits (1863), Expect = 0.0
Identities = 383/698 (54%), Positives = 459/698 (64%), Gaps = 28/698 (4%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXX-XXXNNPIRKLCISIVEWKPFEFLILFMICANCIA 312
+KR KP +Q + NPIR+ CISIVEWKPFE +IL I ANC+A
Sbjct: 81 RKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVA 140
Query: 313 LAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDF 492
LAIY P+P DS+ N+ LE +EY+F+++FT+E LK++A G +FHP+AYLRN WN+LDF
Sbjct: 141 LAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDF 200
Query: 493 IIVVIGLVSTILSKMSIQ-----------GFDVKALRAFRVLRPLRLVSGVPSLQVVLNA 639
IIVV+GL S IL + + GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+
Sbjct: 201 IIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNS 260
Query: 640 ILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPA--TGQLAQKDPTPCGTDT 813
I++AM+PLLHIALLVLFVI+IYAIIGLELF GK+H TC + A+ DP+PC +T
Sbjct: 261 IIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALET 320
Query: 814 EGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDV 993
G +CQ + ++ G W GP +GITNFDNF AMLTVFQC+++EGWTDV
Sbjct: 321 -GHGRQCQ-NGTVCKPG----------WDGPKHGITNFDNFAFAMLTVFQCITMEGWTDV 368
Query: 994 MYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQ 1173
+YWVNDAVGR+WPWIYFVTL+I+GSFFVLNLVLGVLSGEFSKEREKA+ARG FQK REKQ
Sbjct: 369 LYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 428
Query: 1174 QLEEDLKGYLDWITQAEDIEPVNEDEQEDE--------PVAQTXXXXXXXXXXXXXXXXX 1329
QLEEDLKGYLDWITQAEDI+P NEDE DE P ++T
Sbjct: 429 QLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGEN 488
Query: 1330 XPSKWAARMKRLE------KLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQ 1491
++ A R+ + + + N VKS FYW SEHY Q
Sbjct: 489 CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQ 548
Query: 1492 SEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYF 1671
WL Q AN + LF+ EMLLKMYSLG Y S FNRFDCFVV ILE +LV
Sbjct: 549 PNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+M PLG+SVLR RLLRIFK+T+YW
Sbjct: 609 KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668
Query: 1852 GMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGV 2031
GMQ+FGGKFNF+ Q + R+ FD F Q+LLTVFQILTGEDWN+VMY GI ++GG G+
Sbjct: 669 GMQLFGGKFNFDEMQTR-RSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGM 727
Query: 2032 IVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNA 2145
+VCIY+I+LFICGNYILLNVFLAIAVDNLADA+SLT+A
Sbjct: 728 LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSA 765
Score = 131 bits (329), Expect = 2e-28
Identities = 100/342 (29%), Positives = 162/342 (47%), Gaps = 10/342 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V NN R C IV F LILF I + I+L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P Q + ++N +L +YVF +FT+E +LK+ A G H ++ RN +NILD +
Sbjct: 918 AAEDP--VQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLL 975
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S + +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 976 VVSVSLISFGIQSSAINV--VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIV 1033
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ-KDPTPCGTDTEGSAFKCQPSDSL 852
++ + ++A IG++LF GKL+ TC D + A+ K D E QP
Sbjct: 1034 IVTTLLQFMFACIGVQLFKGKLY-TCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRS-- 1090
Query: 853 TNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWP 1032
WE N +FDN AM+ +F + EGW +++Y D+ +
Sbjct: 1091 ------WE-----------NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKG 1133
Query: 1033 WIY---------FVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
IY F+ +I+ +FF++N+ +G + F ++ E+
Sbjct: 1134 PIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1175
Score = 95.9 bits (237), Expect = 1e-17
Identities = 64/259 (24%), Positives = 124/259 (47%), Gaps = 5/259 (1%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S F +++ ++ +NT+++A +HY + D N +F E +LK+ +L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD VV G ++ + + + I+ R R++R+ K+ +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL--VETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + + S +++ + LL+ L I++++GMQ F GK D+ + R + F +FP ++
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT--RRSTFDNFPQSL 696
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNF----AYPYFISF 4044
L +F+ TGE W +M D G G +F YFI
Sbjct: 697 LTVFQILTGEDWNSVMY--------------DGIMAYG------GPSFPGMLVCIYFIIL 736
Query: 4045 FMLCSFLVINLFVAVIMDN 4101
F+ +++++N+F+A+ +DN
Sbjct: 737 FICGNYILLNVFLAIAVDN 755
Score = 90.9 bits (224), Expect = 3e-16
Identities = 88/353 (24%), Positives = 148/353 (40%), Gaps = 54/353 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE +I L I N V+LA +P S L+ +F +F EA LK++A
Sbjct: 124 KPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGL 183
Query: 3511 -LNPKNYISDRWNVFD-LLVVVGSFIDITYGKLNPGGTNLIS-------INFFRLFRVMR 3663
+P Y+ + WN+ D ++VVVG F I G N + + R FRV+R
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLR 243
Query: 3664 LVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV--------- 3813
++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F GK+
Sbjct: 244 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEG 303
Query: 3814 -----ALDDSTSI------------------------HRNNNFHSFPAAILVLFRSATGE 3906
A DD + H NF +F A+L +F+ T E
Sbjct: 304 IADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITME 363
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVA 4086
W D++ +D G ++ + YF++ ++ SF V+NL +
Sbjct: 364 GWTDVLYWVND---------------------AVGRDWPWIYFVTLIIIGSFFVLNLVLG 402
Query: 4087 VIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
V+ F G + +R + + D KG +LD +T I P
Sbjct: 403 VLSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 449
Score = 89.0 bits (219), Expect = 1e-15
Identities = 77/282 (27%), Positives = 122/282 (42%), Gaps = 29/282 (10%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR--NMILNYF 2502
+L L+ N R C +V F +L I + LA P + + N L
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL----RTDAMS 2670
+Y F +FTVE LKVI +GL+FH ++ RN +NLLD ++V V L S +L + D +
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 2671 XXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
A ++ L+ V+ +I A+ + +I L+ + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 2824 AIIGVQLFKGTFF-LCNDLSKMTE-------AECRGEYIH---YEDGDPTKPVSKKRVW- 2967
AIIG++LF G C + + + + C E H ++G KP W
Sbjct: 283 AIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKP-----GWD 337
Query: 2968 --SNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEED 3087
+ NFDN AM+++F T EGW +LY D+ D
Sbjct: 338 GPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRD 379
Score = 82.8 bits (203), Expect = 9e-14
Identities = 73/315 (23%), Positives = 130/315 (41%), Gaps = 33/315 (10%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+L+ +I N I LA+ Q Y Q +K + + +F +FT+E +LK++A F
Sbjct: 1221 FEYLMFVLILLNTICLAM-QHY-GQSCLFK-IAMNILNMLFTGLFTVEMILKLIA----F 1273
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMSI---------------QGFDVKALRAFRV 582
P Y +AWN D +IVV +V +++++ + R FRV
Sbjct: 1274 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRV 1333
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
+R ++L+S ++ +L +++ L ++ALL++ + IYA+IG+++F
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF----------- 1382
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
G++A D T N NF F
Sbjct: 1383 --GKIALNDTTEI------------------------------------NRNNNFQTFPQ 1404
Query: 943 AMLTVFQCVSLEGWTDVMYWV------------------NDAVGREWPWIYFVTLVILGS 1068
A+L +F+C + E W D+M G + YF++ +L +
Sbjct: 1405 AVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCA 1464
Query: 1069 FFVLNLVLGVLSGEF 1113
F ++NL + V+ F
Sbjct: 1465 FLIINLFVAVIMDNF 1479
Score = 69.7 bits (169), Expect = 8e-10
Identities = 55/240 (22%), Positives = 96/240 (39%), Gaps = 27/240 (11%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HYGQS + N+ F LF++EM+LK+ + Y +N FD +V+ SI++
Sbjct: 1239 QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDI 1298
Query: 1657 VLVYFDLMKP--------------LGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXX 1794
+ + + + ++ R R++R+ K+
Sbjct: 1299 AITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQ 1358
Query: 1795 XXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDW 1974
GMQVFG + + NF TF QA+L +F+ TGE W
Sbjct: 1359 ALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAW 1418
Query: 1975 NTVMYHGI-------ESFGGVGTLGVIVC------IYYIVLFICGNYILLNVFLAIAVDN 2115
+M + ES T G C Y+I ++ ++++N+F+A+ +DN
Sbjct: 1419 QDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDN 1478
Score = 43.1 bits (100), Expect = 0.077
Identities = 47/240 (19%), Positives = 88/240 (36%), Gaps = 38/240 (15%)
Frame = +1
Query: 1504 DHFQTMANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYF 1671
+H A+ F +F++E++LKM + G ++ + FN D VV S++ F +
Sbjct: 930 NHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS 989
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+ V +LR R+LR +
Sbjct: 990 AINV---VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACI 1046
Query: 1852 GMQVFGGKFNFNPQQPK------------------------PRA------NFDTFVQALL 1941
G+Q+F GK K PR+ +FD + A++
Sbjct: 1047 GVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMM 1106
Query: 1942 TVFQILTGEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+F + T E W ++Y I+S G + V + I++I+ I + ++N+F+ +
Sbjct: 1107 ALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1166
>gi|509168|emb|CAA84346.1| voltage-dependent L-type Ca channel alpha 1
subunit [Homo sapiens]
Length = 2138
Score = 1023 bits (2645), Expect = 0.0
Identities = 510/830 (61%), Positives = 639/830 (76%), Gaps = 12/830 (1%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPR +SE+ P+P+AS+ FI S N FR+ C+ +VN + FTN +LF IL+SS L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP+Q S RN IL DY FTS+FT+EI LK+ +G HKGSFCRN FN+LD+LVV
Sbjct: 918 AAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVV 977
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
+VSL SF +++ A++ AINRAKGLKHVVQCV VA++TIGNI++VT
Sbjct: 978 SVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 1037
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG + C+D SK TEAEC+G YI Y+DG+ P+ + R W N+ F+
Sbjct: 1038 LLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFD 1097
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP+LLY +IDS+ EDKGPI+N R +++
Sbjct: 1098 FDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFM 1157
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N+ QY+VW+ V
Sbjct: 1158 MNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVN 1217
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S F+ +++ N++FTG+F E +LK++A PK+
Sbjct: 1218 STYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKH 1277
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGG------------TNLISINFFRLFRVMRLV 3669
Y D WN FD L+VVGS +DI ++NP + ISI FFRLFRVMRLV
Sbjct: 1278 YFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLV 1337
Query: 3670 KLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNN 3849
KLLSRGEGIRTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL+D+T I+RNN
Sbjct: 1338 KLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNN 1397
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FP A+L+LFR ATGEAWQDIML+C + +C P S+ + E+ CG++FA
Sbjct: 1398 NFQTFPQAVLLLFRCATGEAWQDIMLACMPGK--KCAPESEPSNSTE-GETPCGSSFAVF 1454
Query: 4030 YFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKH 4209
YFISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+W+EYDP+AKGRIKH
Sbjct: 1455 YFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKH 1514
Query: 4210 LDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYT 4389
LDVVTLLR+I PPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFALVRT L+I T
Sbjct: 1515 LDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKT 1574
Query: 4390 EGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKK 4569
EGN+++ANE+LR+ IK+IWKRT LLD+VVPPAG +D+VTVGKFYATFLIQ+YFR+FKK
Sbjct: 1575 EGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQEYFRKFKK 1633
Query: 4570 RKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDE 4719
RKE G P+Q A++LQAGLRTLH+IGPE++RAISG+L + D+
Sbjct: 1634 RKEQGLVG-KPSQR-NALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDK 1681
Score = 722 bits (1863), Expect = 0.0
Identities = 383/698 (54%), Positives = 459/698 (64%), Gaps = 28/698 (4%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXX-XXXNNPIRKLCISIVEWKPFEFLILFMICANCIA 312
+KR KP +Q + NPIR+ CISIVEWKPFE +IL I ANC+A
Sbjct: 81 RKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVA 140
Query: 313 LAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDF 492
LAIY P+P DS+ N+ LE +EY+F+++FT+E LK++A G +FHP+AYLRN WN+LDF
Sbjct: 141 LAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDF 200
Query: 493 IIVVIGLVSTILSKMSIQ-----------GFDVKALRAFRVLRPLRLVSGVPSLQVVLNA 639
IIVV+GL S IL + + GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+
Sbjct: 201 IIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNS 260
Query: 640 ILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPA--TGQLAQKDPTPCGTDT 813
I++AM+PLLHIALLVLFVI+IYAIIGLELF GK+H TC + A+ DP+PC +T
Sbjct: 261 IIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALET 320
Query: 814 EGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDV 993
G +CQ + ++ G W GP +GITNFDNF AMLTVFQC+++EGWTDV
Sbjct: 321 -GHGRQCQ-NGTVCKPG----------WDGPKHGITNFDNFAFAMLTVFQCITMEGWTDV 368
Query: 994 MYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQ 1173
+YWVNDAVGR+WPWIYFVTL+I+GSFFVLNLVLGVLSGEFSKEREKA+ARG FQK REKQ
Sbjct: 369 LYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 428
Query: 1174 QLEEDLKGYLDWITQAEDIEPVNEDEQEDE--------PVAQTXXXXXXXXXXXXXXXXX 1329
QLEEDLKGYLDWITQAEDI+P NEDE DE P ++T
Sbjct: 429 QLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGEN 488
Query: 1330 XPSKWAARMKRLE------KLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQ 1491
++ A R+ + + + N VKS FYW SEHY Q
Sbjct: 489 CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQ 548
Query: 1492 SEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYF 1671
WL Q AN + LF+ EMLLKMYSLG Y S FNRFDCFVV ILE +LV
Sbjct: 549 PNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+M PLG+SVLR RLLRIFK+T+YW
Sbjct: 609 KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668
Query: 1852 GMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGV 2031
GMQ+FGGKFNF+ Q + R+ FD F Q+LLTVFQILTGEDWN+VMY GI ++GG G+
Sbjct: 669 GMQLFGGKFNFDEMQTR-RSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGM 727
Query: 2032 IVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNA 2145
+VCIY+I+LFICGNYILLNVFLAIAVDNLADA+SLT+A
Sbjct: 728 LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSA 765
Score = 131 bits (329), Expect = 2e-28
Identities = 100/342 (29%), Positives = 162/342 (47%), Gaps = 10/342 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V NN R C IV F LILF I + I+L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P Q + ++N +L +YVF +FT+E +LK+ A G H ++ RN +NILD +
Sbjct: 918 AAEDP--VQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLL 975
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S + +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 976 VVSVSLISFGIQSSAINV--VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIV 1033
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ-KDPTPCGTDTEGSAFKCQPSDSL 852
++ + ++A IG++LF GKL+ TC D + A+ K D E QP
Sbjct: 1034 IVTTLLQFMFACIGVQLFKGKLY-TCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRS-- 1090
Query: 853 TNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWP 1032
WE N +FDN AM+ +F + EGW +++Y D+ +
Sbjct: 1091 ------WE-----------NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKG 1133
Query: 1033 WIY---------FVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
IY F+ +I+ +FF++N+ +G + F ++ E+
Sbjct: 1134 PIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1175
Score = 95.9 bits (237), Expect = 1e-17
Identities = 64/259 (24%), Positives = 124/259 (47%), Gaps = 5/259 (1%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S F +++ ++ +NT+++A +HY + D N +F E +LK+ +L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD VV G ++ + + + I+ R R++R+ K+ +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL--VETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + + S +++ + LL+ L I++++GMQ F GK D+ + R + F +FP ++
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT--RRSTFDNFPQSL 696
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNF----AYPYFISF 4044
L +F+ TGE W +M D G G +F YFI
Sbjct: 697 LTVFQILTGEDWNSVMY--------------DGIMAYG------GPSFPGMLVCIYFIIL 736
Query: 4045 FMLCSFLVINLFVAVIMDN 4101
F+ +++++N+F+A+ +DN
Sbjct: 737 FICGNYILLNVFLAIAVDN 755
Score = 90.9 bits (224), Expect = 3e-16
Identities = 88/353 (24%), Positives = 148/353 (40%), Gaps = 54/353 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE +I L I N V+LA +P S L+ +F +F EA LK++A
Sbjct: 124 KPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGL 183
Query: 3511 -LNPKNYISDRWNVFD-LLVVVGSFIDITYGKLNPGGTNLIS-------INFFRLFRVMR 3663
+P Y+ + WN+ D ++VVVG F I G N + + R FRV+R
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLR 243
Query: 3664 LVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV--------- 3813
++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F GK+
Sbjct: 244 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEG 303
Query: 3814 -----ALDDSTSI------------------------HRNNNFHSFPAAILVLFRSATGE 3906
A DD + H NF +F A+L +F+ T E
Sbjct: 304 IADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITME 363
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVA 4086
W D++ +D G ++ + YF++ ++ SF V+NL +
Sbjct: 364 GWTDVLYWVND---------------------AVGRDWPWIYFVTLIIIGSFFVLNLVLG 402
Query: 4087 VIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
V+ F G + +R + + D KG +LD +T I P
Sbjct: 403 VLSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 449
Score = 89.0 bits (219), Expect = 1e-15
Identities = 77/282 (27%), Positives = 122/282 (42%), Gaps = 29/282 (10%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR--NMILNYF 2502
+L L+ N R C +V F +L I + LA P + + N L
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL----RTDAMS 2670
+Y F +FTVE LKVI +GL+FH ++ RN +NLLD ++V V L S +L + D +
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 2671 XXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
A ++ L+ V+ +I A+ + +I L+ + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 2824 AIIGVQLFKGTFF-LCNDLSKMTE-------AECRGEYIH---YEDGDPTKPVSKKRVW- 2967
AIIG++LF G C + + + + C E H ++G KP W
Sbjct: 283 AIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKP-----GWD 337
Query: 2968 --SNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEED 3087
+ NFDN AM+++F T EGW +LY D+ D
Sbjct: 338 GPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRD 379
Score = 82.8 bits (203), Expect = 9e-14
Identities = 73/315 (23%), Positives = 130/315 (41%), Gaps = 33/315 (10%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+L+ +I N I LA+ Q Y Q +K + + +F +FT+E +LK++A F
Sbjct: 1221 FEYLMFVLILLNTICLAM-QHY-GQSCLFK-IAMNILNMLFTGLFTVEMILKLIA----F 1273
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMSI---------------QGFDVKALRAFRV 582
P Y +AWN D +IVV +V +++++ + R FRV
Sbjct: 1274 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRV 1333
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
+R ++L+S ++ +L +++ L ++ALL++ + IYA+IG+++F
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF----------- 1382
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
G++A D T N NF F
Sbjct: 1383 --GKIALNDTTEI------------------------------------NRNNNFQTFPQ 1404
Query: 943 AMLTVFQCVSLEGWTDVMYWV------------------NDAVGREWPWIYFVTLVILGS 1068
A+L +F+C + E W D+M G + YF++ +L +
Sbjct: 1405 AVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCA 1464
Query: 1069 FFVLNLVLGVLSGEF 1113
F ++NL + V+ F
Sbjct: 1465 FLIINLFVAVIMDNF 1479
Score = 69.7 bits (169), Expect = 8e-10
Identities = 55/240 (22%), Positives = 96/240 (39%), Gaps = 27/240 (11%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HYGQS + N+ F LF++EM+LK+ + Y +N FD +V+ SI++
Sbjct: 1239 QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDI 1298
Query: 1657 VLVYFDLMKP--------------LGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXX 1794
+ + + + ++ R R++R+ K+
Sbjct: 1299 AITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQ 1358
Query: 1795 XXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDW 1974
GMQVFG + + NF TF QA+L +F+ TGE W
Sbjct: 1359 ALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAW 1418
Query: 1975 NTVMYHGI-------ESFGGVGTLGVIVC------IYYIVLFICGNYILLNVFLAIAVDN 2115
+M + ES T G C Y+I ++ ++++N+F+A+ +DN
Sbjct: 1419 QDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDN 1478
Score = 43.1 bits (100), Expect = 0.077
Identities = 47/240 (19%), Positives = 88/240 (36%), Gaps = 38/240 (15%)
Frame = +1
Query: 1504 DHFQTMANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYF 1671
+H A+ F +F++E++LKM + G ++ + FN D VV S++ F +
Sbjct: 930 NHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS 989
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+ V +LR R+LR +
Sbjct: 990 AINV---VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACI 1046
Query: 1852 GMQVFGGKFNFNPQQPK------------------------PRA------NFDTFVQALL 1941
G+Q+F GK K PR+ +FD + A++
Sbjct: 1047 GVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMM 1106
Query: 1942 TVFQILTGEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+F + T E W ++Y I+S G + V + I++I+ I + ++N+F+ +
Sbjct: 1107 ALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1166
>gi|2960067|emb|CAA12174.1| voltage-dependent L-type calcium channel
alpha-1C subunit [Homo sapiens]
Length = 2138
Score = 1023 bits (2645), Expect = 0.0
Identities = 510/830 (61%), Positives = 639/830 (76%), Gaps = 12/830 (1%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPR +SE+ P+P+AS+ FI S N FR+ C+ +VN + FTN +LF IL+SS L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP+Q S RN IL DY FTS+FT+EI LK+ +G HKGSFCRN FN+LD+LVV
Sbjct: 918 AAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVV 977
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
+VSL SF +++ A++ AINRAKGLKHVVQCV VA++TIGNI++VT
Sbjct: 978 SVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 1037
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG + C+D SK TEAEC+G YI Y+DG+ P+ + R W N+ F+
Sbjct: 1038 LLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFD 1097
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP+LLY +IDS+ EDKGPI+N R +++
Sbjct: 1098 FDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFM 1157
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N+ QY+VW+ V
Sbjct: 1158 MNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVN 1217
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S F+ +++ N++FTG+F E +LK++A PK+
Sbjct: 1218 STYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKH 1277
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGG------------TNLISINFFRLFRVMRLV 3669
Y D WN FD L+VVGS +DI ++NP + ISI FFRLFRVMRLV
Sbjct: 1278 YFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLV 1337
Query: 3670 KLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNN 3849
KLLSRGEGIRTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL+D+T I+RNN
Sbjct: 1338 KLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNN 1397
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FP A+L+LFR ATGEAWQDIML+C + +C P S+ + E+ CG++FA
Sbjct: 1398 NFQTFPQAVLLLFRCATGEAWQDIMLACMPGK--KCAPESEPSNSTE-GETPCGSSFAVF 1454
Query: 4030 YFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKH 4209
YFISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+W+EYDP+AKGRIKH
Sbjct: 1455 YFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKH 1514
Query: 4210 LDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYT 4389
LDVVTLLR+I PPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFALVRT L+I T
Sbjct: 1515 LDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKT 1574
Query: 4390 EGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKK 4569
EGN+++ANE+LR+ IK+IWKRT LLD+VVPPAG +D+VTVGKFYATFLIQ+YFR+FKK
Sbjct: 1575 EGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQEYFRKFKK 1633
Query: 4570 RKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDE 4719
RKE G P+Q A++LQAGLRTLH+IGPE++RAISG+L + D+
Sbjct: 1634 RKEQGLVG-KPSQR-NALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDK 1681
Score = 708 bits (1828), Expect = 0.0
Identities = 378/698 (54%), Positives = 455/698 (65%), Gaps = 28/698 (4%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXX-XXXNNPIRKLCISIVEWKPFEFLILFMICANCIA 312
+KR KP +Q + NPIR+ CISIVEWKPFE +IL I ANC+A
Sbjct: 81 RKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVA 140
Query: 313 LAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDF 492
LAIY P+P DS+ N+ LE +EY+F+++FT+E LK++A G +FHP+AYLRN WN+LDF
Sbjct: 141 LAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDF 200
Query: 493 IIVVIGLVSTILSKMSIQ-----------GFDVKALRAFRVLRPLRLVSGVPSLQVVLNA 639
IIVV+GL S IL + + GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+
Sbjct: 201 IIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNS 260
Query: 640 ILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPA--TGQLAQKDPTPCGTDT 813
I++AM+PLLHIALLVLFVI+IYAIIGLELF GK+H TC + A+ DP+PC +T
Sbjct: 261 IIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALET 320
Query: 814 EGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDV 993
G +CQ + ++ G W GP +GITNFDNF AMLTVFQC+++EGWTDV
Sbjct: 321 -GHGRQCQ-NGTVCKPG----------WDGPKHGITNFDNFAFAMLTVFQCITMEGWTDV 368
Query: 994 MYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQ 1173
+YW+ DA+G E PW+YFV+LVI GSFFVLNLVLGVLSGEFSKEREKA+ARG FQK REKQ
Sbjct: 369 LYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 428
Query: 1174 QLEEDLKGYLDWITQAEDIEPVNEDEQEDE--------PVAQTXXXXXXXXXXXXXXXXX 1329
QLEEDLKGYLDWITQAEDI+P NEDE DE P ++T
Sbjct: 429 QLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGEN 488
Query: 1330 XPSKWAARMKRLE------KLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQ 1491
++ A R+ + + + N VKS FYW SEHY Q
Sbjct: 489 CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQ 548
Query: 1492 SEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYF 1671
WL Q AN + LF+ EMLLKMYSLG Y S FNRFDCFVV ILE +LV
Sbjct: 549 PNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+M PLG+SVLR RLLRIFK+T+YW
Sbjct: 609 KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668
Query: 1852 GMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGV 2031
GMQ+FGGKFNF+ Q + R+ FD F Q+LLTVFQILTGEDWN+VMY GI ++GG G+
Sbjct: 669 GMQLFGGKFNFDEMQTR-RSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGM 727
Query: 2032 IVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNA 2145
+VCIY+I+LFICGNYILLNVFLAIAVDNLADA+SLT+A
Sbjct: 728 LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSA 765
Score = 131 bits (329), Expect = 2e-28
Identities = 100/342 (29%), Positives = 162/342 (47%), Gaps = 10/342 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V NN R C IV F LILF I + I+L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P Q + ++N +L +YVF +FT+E +LK+ A G H ++ RN +NILD +
Sbjct: 918 AAEDP--VQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLL 975
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S + +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 976 VVSVSLISFGIQSSAINV--VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIV 1033
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ-KDPTPCGTDTEGSAFKCQPSDSL 852
++ + ++A IG++LF GKL+ TC D + A+ K D E QP
Sbjct: 1034 IVTTLLQFMFACIGVQLFKGKLY-TCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRS-- 1090
Query: 853 TNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWP 1032
WE N +FDN AM+ +F + EGW +++Y D+ +
Sbjct: 1091 ------WE-----------NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKG 1133
Query: 1033 WIY---------FVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
IY F+ +I+ +FF++N+ +G + F ++ E+
Sbjct: 1134 PIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1175
Score = 95.9 bits (237), Expect = 1e-17
Identities = 64/259 (24%), Positives = 124/259 (47%), Gaps = 5/259 (1%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S F +++ ++ +NT+++A +HY + D N +F E +LK+ +L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD VV G ++ + + + I+ R R++R+ K+ +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL--VETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + + S +++ + LL+ L I++++GMQ F GK D+ + R + F +FP ++
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT--RRSTFDNFPQSL 696
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNF----AYPYFISF 4044
L +F+ TGE W +M D G G +F YFI
Sbjct: 697 LTVFQILTGEDWNSVMY--------------DGIMAYG------GPSFPGMLVCIYFIIL 736
Query: 4045 FMLCSFLVINLFVAVIMDN 4101
F+ +++++N+F+A+ +DN
Sbjct: 737 FICGNYILLNVFLAIAVDN 755
Score = 89.4 bits (220), Expect = 9e-16
Identities = 89/353 (25%), Positives = 144/353 (40%), Gaps = 54/353 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE +I L I N V+LA +P S L+ +F +F EA LK++A
Sbjct: 124 KPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGL 183
Query: 3511 -LNPKNYISDRWNVFD-LLVVVGSFIDITYGKLNPGGTNLIS-------INFFRLFRVMR 3663
+P Y+ + WN+ D ++VVVG F I G N + + R FRV+R
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLR 243
Query: 3664 LVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV--------- 3813
++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F GK+
Sbjct: 244 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEG 303
Query: 3814 -----ALDDSTSI------------------------HRNNNFHSFPAAILVLFRSATGE 3906
A DD + H NF +F A+L +F+ T E
Sbjct: 304 IADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITME 363
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVA 4086
W D++ D G + YF+S + SF V+NL +
Sbjct: 364 GWTDVLYWMQD---------------------AMGYELPWVYFVSLVIFGSFFVLNLVLG 402
Query: 4087 VIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
V+ F G + +R + + D KG +LD +T I P
Sbjct: 403 VLSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 449
Score = 88.2 bits (217), Expect = 2e-15
Identities = 75/273 (27%), Positives = 119/273 (43%), Gaps = 29/273 (10%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR--NMILNYF 2502
+L L+ N R C +V F +L I + LA P + + N L
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL----RTDAMS 2670
+Y F +FTVE LKVI +GL+FH ++ RN +NLLD ++V V L S +L + D +
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 2671 XXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
A ++ L+ V+ +I A+ + +I L+ + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 2824 AIIGVQLFKGTFF-LCNDLSKMTE-------AECRGEYIH---YEDGDPTKPVSKKRVW- 2967
AIIG++LF G C + + + + C E H ++G KP W
Sbjct: 283 AIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKP-----GWD 337
Query: 2968 --SNNDFNFDNVGDAMISLFVVSTFEGWPQLLY 3060
+ NFDN AM+++F T EGW +LY
Sbjct: 338 GPKHGITNFDNFAFAMLTVFQCITMEGWTDVLY 370
Score = 82.8 bits (203), Expect = 9e-14
Identities = 73/315 (23%), Positives = 130/315 (41%), Gaps = 33/315 (10%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+L+ +I N I LA+ Q Y Q +K + + +F +FT+E +LK++A F
Sbjct: 1221 FEYLMFVLILLNTICLAM-QHY-GQSCLFK-IAMNILNMLFTGLFTVEMILKLIA----F 1273
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMSI---------------QGFDVKALRAFRV 582
P Y +AWN D +IVV +V +++++ + R FRV
Sbjct: 1274 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRV 1333
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
+R ++L+S ++ +L +++ L ++ALL++ + IYA+IG+++F
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF----------- 1382
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
G++A D T N NF F
Sbjct: 1383 --GKIALNDTTEI------------------------------------NRNNNFQTFPQ 1404
Query: 943 AMLTVFQCVSLEGWTDVMYWV------------------NDAVGREWPWIYFVTLVILGS 1068
A+L +F+C + E W D+M G + YF++ +L +
Sbjct: 1405 AVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCA 1464
Query: 1069 FFVLNLVLGVLSGEF 1113
F ++NL + V+ F
Sbjct: 1465 FLIINLFVAVIMDNF 1479
Score = 69.7 bits (169), Expect = 8e-10
Identities = 55/240 (22%), Positives = 96/240 (39%), Gaps = 27/240 (11%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HYGQS + N+ F LF++EM+LK+ + Y +N FD +V+ SI++
Sbjct: 1239 QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDI 1298
Query: 1657 VLVYFDLMKP--------------LGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXX 1794
+ + + + ++ R R++R+ K+
Sbjct: 1299 AITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQ 1358
Query: 1795 XXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDW 1974
GMQVFG + + NF TF QA+L +F+ TGE W
Sbjct: 1359 ALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAW 1418
Query: 1975 NTVMYHGI-------ESFGGVGTLGVIVC------IYYIVLFICGNYILLNVFLAIAVDN 2115
+M + ES T G C Y+I ++ ++++N+F+A+ +DN
Sbjct: 1419 QDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDN 1478
Score = 43.1 bits (100), Expect = 0.077
Identities = 47/240 (19%), Positives = 88/240 (36%), Gaps = 38/240 (15%)
Frame = +1
Query: 1504 DHFQTMANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYF 1671
+H A+ F +F++E++LKM + G ++ + FN D VV S++ F +
Sbjct: 930 NHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS 989
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+ V +LR R+LR +
Sbjct: 990 AINV---VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACI 1046
Query: 1852 GMQVFGGKFNFNPQQPK------------------------PRA------NFDTFVQALL 1941
G+Q+F GK K PR+ +FD + A++
Sbjct: 1047 GVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMM 1106
Query: 1942 TVFQILTGEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+F + T E W ++Y I+S G + V + I++I+ I + ++N+F+ +
Sbjct: 1107 ALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1166
>gi|17864838|gb|AAL47072.1| L-type calcium channel alpha-1c subunit
[Rattus norvegicus]
Length = 2170
Score = 1023 bits (2645), Expect = 0.0
Identities = 509/830 (61%), Positives = 640/830 (76%), Gaps = 12/830 (1%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPR +SE+ P+P+AS+ FI S N FR+ C+ +VN + FTN +LF IL+SS L
Sbjct: 888 RPRPLSELHLKEKAVPMPEASAFFIFSPNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 947
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP+Q S RN IL YFD FT++FT+EI LK+ +G HKGSFCRN FN+LD+LVV
Sbjct: 948 AAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVV 1007
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
+VSL SF +++ A++ AINRAKGLKHVVQCV VA++TIGNI++VT
Sbjct: 1008 SVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 1067
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG + C+D SK TEAEC+G YI Y+DG+ P+ + R W N+ F+
Sbjct: 1068 LLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFD 1127
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP+LLY +IDS+ EDKGPI+N R +++
Sbjct: 1128 FDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFM 1187
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N+ QY+VW+ V
Sbjct: 1188 MNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVN 1247
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S F+ +++ N++FTG+F E +LK++A PK+
Sbjct: 1248 STYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKH 1307
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGG------------TNLISINFFRLFRVMRLV 3669
Y D WN FD L+VVGS +DI +++P + ISI FFRLFRVMRLV
Sbjct: 1308 YFCDAWNTFDALIVVGSIVDIAITEVHPAEHTQCSPSMSAEENSRISITFFRLFRVMRLV 1367
Query: 3670 KLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNN 3849
KLLSRGEGIRTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL+D+T I+RNN
Sbjct: 1368 KLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNN 1427
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FP A+L+LFR ATGEAWQDIML+C + +C P S+ + E+ CG++FA
Sbjct: 1428 NFQTFPQAVLLLFRCATGEAWQDIMLACMPGK--KCAPESEPSNSTE-GETPCGSSFAVF 1484
Query: 4030 YFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKH 4209
YFISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+W+EYDP+AKGRIKH
Sbjct: 1485 YFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKH 1544
Query: 4210 LDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYT 4389
LDVVTLLR+I PPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFALVRT L+I T
Sbjct: 1545 LDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKT 1604
Query: 4390 EGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKK 4569
EGN+++ANE+LR+ IK+IWKRT LLD+VVPPAG +D+VTVGKFYATFLIQ+YFR+FKK
Sbjct: 1605 EGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQEYFRKFKK 1663
Query: 4570 RKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDE 4719
RKE G P+Q A++LQAGLRTLH+IGPE++RAISG+L + D+
Sbjct: 1664 RKEQGLVG-KPSQR-NALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDK 1711
Score = 708 bits (1827), Expect = 0.0
Identities = 372/668 (55%), Positives = 448/668 (66%), Gaps = 27/668 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR+ CISIVEWKPFE +IL I ANC+ALAIY P+P DS+ N+ LE +EY+F+++F
Sbjct: 141 NPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIF 200
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQ-----------G 549
T+E LK++A G +FHP+AYLRN WN+LDFIIVV+GL S IL + + G
Sbjct: 201 TVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAG 260
Query: 550 FDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELF 729
FDVKALRAFRVLRPLRLVSGVPSLQVVLN+I++AM+PLLHIALLVLFVI+IYAIIGLELF
Sbjct: 261 FDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELF 320
Query: 730 CGKLHSTCIDPA--TGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPG 903
GK+H TC + A++DP+PC +T G +CQ + ++ G W G
Sbjct: 321 MGKMHKTCYNQEGIIDVPAEEDPSPCALET-GHGRQCQ-NGTVCKPG----------WDG 368
Query: 904 PNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLN 1083
P +GITNFDNF AMLTVFQC+++EGWTDV+YW+ DA+G E PW+YFV+LVI GSFFVLN
Sbjct: 369 PKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLN 428
Query: 1084 LVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDE 1263
LVLGVLSGEFSKEREKA+ARG FQK REKQQLEEDLKGYLDWITQAEDI+P NEDE DE
Sbjct: 429 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDE 488
Query: 1264 --------PVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLE------KLNXXXXXXXX 1401
P ++T ++ A R+ + + + N
Sbjct: 489 DKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCR 548
Query: 1402 XLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSL 1581
VKS FYW SEHY Q WL Q AN + LF+ EMLLKMYSL
Sbjct: 549 AAVKSNVFYWLVIFLVFLNTLTIASEHYNQPHWLTEVQDTANKALLALFTAEMLLKMYSL 608
Query: 1582 GFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXX 1761
G Y S FNRFDCF+V ILE +LV +M PLG+SVLR RLLRIFK+T+YW
Sbjct: 609 GLQAYFVSLFNRFDCFIVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 668
Query: 1762 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALL 1941
GMQ+FGGKFNF+ Q + R+ FD F Q+LL
Sbjct: 669 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTR-RSTFDNFPQSLL 727
Query: 1942 TVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLA 2121
TVFQILTGEDWN+VMY GI ++GG G++VCIY+I+LFICGNYILLNVFLAIAVDNLA
Sbjct: 728 TVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLA 787
Query: 2122 DADSLTNA 2145
DA+SLT+A
Sbjct: 788 DAESLTSA 795
Score = 127 bits (318), Expect = 4e-27
Identities = 100/342 (29%), Positives = 160/342 (46%), Gaps = 10/342 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V NN R C IV F LILF I + I+L
Sbjct: 888 RPRPLSELHLKEKAVPMPEASAFFIFSPNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 947
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P Q + ++N +L + VF +FTIE LK+ A G H ++ RN +NILD +
Sbjct: 948 AAEDP--VQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLL 1005
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S + +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 1006 VVSVSLISFGIQSSAINV--VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIV 1063
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ-KDPTPCGTDTEGSAFKCQPSDSL 852
++ + ++A IG++LF GKL+ TC D + A+ K D E QP
Sbjct: 1064 IVTTLLQFMFACIGVQLFKGKLY-TCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRS-- 1120
Query: 853 TNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWP 1032
WE N +FDN AM+ +F + EGW +++Y D+ +
Sbjct: 1121 ------WE-----------NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKG 1163
Query: 1033 WIY---------FVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
IY F+ +I+ +FF++N+ +G + F ++ E+
Sbjct: 1164 PIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1205
Score = 95.5 bits (236), Expect = 1e-17
Identities = 63/259 (24%), Positives = 124/259 (47%), Gaps = 5/259 (1%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S F +++ ++ +NT+++A +HY + D N +F E +LK+ +L
Sbjct: 551 VKSNVFYWLVIFLVFLNTLTIASEHYNQPHWLTEVQDTANKALLALFTAEMLLKMYSLGL 610
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD +V G ++ + + + I+ R R++R+ K+ +
Sbjct: 611 QAYFVSLFNRFDCFIVCGGILETIL--VETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 668
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + + S +++ + LL+ L I++++GMQ F GK D+ + R + F +FP ++
Sbjct: 669 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT--RRSTFDNFPQSL 726
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNF----AYPYFISF 4044
L +F+ TGE W +M D G G +F YFI
Sbjct: 727 LTVFQILTGEDWNSVMY--------------DGIMAYG------GPSFPGMLVCIYFIIL 766
Query: 4045 FMLCSFLVINLFVAVIMDN 4101
F+ +++++N+F+A+ +DN
Sbjct: 767 FICGNYILLNVFLAIAVDN 785
Score = 87.8 bits (216), Expect = 3e-15
Identities = 74/273 (27%), Positives = 119/273 (43%), Gaps = 29/273 (10%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR--NMILNYF 2502
+L L+ N R C +V F +L I + LA P + + N L
Sbjct: 133 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 192
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL----RTDAMS 2670
+Y F +FTVE LKVI +GL+FH ++ RN +NLLD ++V V L S +L + D +
Sbjct: 193 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 252
Query: 2671 XXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
A ++ L+ V+ +I A+ + +I L+ + ++
Sbjct: 253 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 312
Query: 2824 AIIGVQLFKGTFF--------LCNDLSKMTEAECRGEYIH---YEDGDPTKPVSKKRVW- 2967
AIIG++LF G + + ++ + C E H ++G KP W
Sbjct: 313 AIIGLELFMGKMHKTCYNQEGIIDVPAEEDPSPCALETGHGRQCQNGTVCKP-----GWD 367
Query: 2968 --SNNDFNFDNVGDAMISLFVVSTFEGWPQLLY 3060
+ NFDN AM+++F T EGW +LY
Sbjct: 368 GPKHGITNFDNFAFAMLTVFQCITMEGWTDVLY 400
Score = 87.8 bits (216), Expect = 3e-15
Identities = 88/353 (24%), Positives = 144/353 (39%), Gaps = 54/353 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE +I L I N V+LA +P S L+ +F +F EA LK++A
Sbjct: 154 KPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGL 213
Query: 3511 -LNPKNYISDRWNVFD-LLVVVGSFIDITYGKLNPGGTNLIS-------INFFRLFRVMR 3663
+P Y+ + WN+ D ++VVVG F I G N + + R FRV+R
Sbjct: 214 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLR 273
Query: 3664 LVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV--------- 3813
++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F GK+
Sbjct: 274 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEG 333
Query: 3814 -----ALDDSTSI------------------------HRNNNFHSFPAAILVLFRSATGE 3906
A +D + H NF +F A+L +F+ T E
Sbjct: 334 IIDVPAEEDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITME 393
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVA 4086
W D++ D G + YF+S + SF V+NL +
Sbjct: 394 GWTDVLYWMQD---------------------AMGYELPWVYFVSLVIFGSFFVLNLVLG 432
Query: 4087 VIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
V+ F G + +R + + D KG +LD +T I P
Sbjct: 433 VLSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 479
Score = 82.8 bits (203), Expect = 9e-14
Identities = 75/315 (23%), Positives = 131/315 (40%), Gaps = 33/315 (10%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+L+ +I N I LA+ Q Y Q +K + + +F +FT+E +LK++A F
Sbjct: 1251 FEYLMFVLILLNTICLAM-QHY-GQSCLFK-IAMNILNMLFTGLFTVEMILKLIA----F 1303
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSK------------MSIQG---FDVKALRAFRV 582
P Y +AWN D +IVV +V +++ MS + + R FRV
Sbjct: 1304 KPKHYFCDAWNTFDALIVVGSIVDIAITEVHPAEHTQCSPSMSAEENSRISITFFRLFRV 1363
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
+R ++L+S ++ +L +++ L ++ALL++ + IYA+IG+++F
Sbjct: 1364 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF----------- 1412
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
G++A D T N NF F
Sbjct: 1413 --GKIALNDTTEI------------------------------------NRNNNFQTFPQ 1434
Query: 943 AMLTVFQCVSLEGWTDVMYWV------------------NDAVGREWPWIYFVTLVILGS 1068
A+L +F+C + E W D+M G + YF++ +L +
Sbjct: 1435 AVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCA 1494
Query: 1069 FFVLNLVLGVLSGEF 1113
F ++NL + V+ F
Sbjct: 1495 FLIINLFVAVIMDNF 1509
Score = 69.3 bits (168), Expect = 1e-09
Identities = 55/240 (22%), Positives = 95/240 (38%), Gaps = 27/240 (11%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HYGQS + N+ F LF++EM+LK+ + Y +N FD +V+ SI++
Sbjct: 1269 QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDI 1328
Query: 1657 VLVYF--------------DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXX 1794
+ + + ++ R R++R+ K+
Sbjct: 1329 AITEVHPAEHTQCSPSMSAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQ 1388
Query: 1795 XXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDW 1974
GMQVFG + + NF TF QA+L +F+ TGE W
Sbjct: 1389 ALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAW 1448
Query: 1975 NTVMYHGI-------ESFGGVGTLGVIVC------IYYIVLFICGNYILLNVFLAIAVDN 2115
+M + ES T G C Y+I ++ ++++N+F+A+ +DN
Sbjct: 1449 QDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDN 1508
Score = 41.2 bits (95), Expect = 0.29
Identities = 46/240 (19%), Positives = 87/240 (36%), Gaps = 38/240 (15%)
Frame = +1
Query: 1504 DHFQTMANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYF 1671
+H ++ F +F++E+ LKM + G ++ + FN D VV S++ F +
Sbjct: 960 NHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS 1019
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+ V +LR R+LR +
Sbjct: 1020 AINV---VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACI 1076
Query: 1852 GMQVFGGKFNFNPQQPK------------------------PRA------NFDTFVQALL 1941
G+Q+F GK K PR+ +FD + A++
Sbjct: 1077 GVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMM 1136
Query: 1942 TVFQILTGEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+F + T E W ++Y I+S G + V + I++I+ I + ++N+F+ +
Sbjct: 1137 ALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1196
>gi|206578|gb|AAA18905.1| calcium channel alpha-1 subunit
Length = 2143
Score = 1021 bits (2639), Expect = 0.0
Identities = 509/830 (61%), Positives = 639/830 (76%), Gaps = 12/830 (1%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPR +SE+ P+P+AS+ FI S N FR+ C+ +VN + FTN +LF IL+SS L
Sbjct: 861 RPRPLSELHLKEKAVPMPEASAFFIFSPNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 920
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP+Q S RN IL DY FTS+FT+EI LK+ +G HKGSFCRN FN+LD+LVV
Sbjct: 921 AAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVV 980
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
+VSL SF +++ A++ AINRAKGLKHVVQCV VA++TIGNI++VT
Sbjct: 981 SVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 1040
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG + C+D SK TEAEC+G YI Y+DG+ P+ + R W N+ F+
Sbjct: 1041 LLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFD 1100
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP+LLY +IDS+ EDKGPI+N R +++
Sbjct: 1101 FDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFM 1160
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N+ QY+VW+ V
Sbjct: 1161 MNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVN 1220
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S F+ +++ N++FTG+F E +LK++A PK+
Sbjct: 1221 STYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKH 1280
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGG------------TNLISINFFRLFRVMRLV 3669
Y D WN FD L+VVGS +DI +++P + ISI FFRLFRVMRLV
Sbjct: 1281 YFCDAWNTFDALIVVGSIVDIAITEVHPAEHTQCSPSMSAEENSRISITFFRLFRVMRLV 1340
Query: 3670 KLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNN 3849
KLLSRGEGIRTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL+D+T I+RNN
Sbjct: 1341 KLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNN 1400
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FP A+L+LFR ATGEAWQDIML+C + +C P S+ + E+ CG++FA
Sbjct: 1401 NFQTFPQAVLLLFRCATGEAWQDIMLACMPGK--KCAPESEPSNSTK-GETPCGSSFAVF 1457
Query: 4030 YFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKH 4209
YFISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+W+EYDP+AKGRIKH
Sbjct: 1458 YFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKH 1517
Query: 4210 LDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYT 4389
LDVVTLLR+I PPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFALVRT L+I T
Sbjct: 1518 LDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKT 1577
Query: 4390 EGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKK 4569
EGN+++ANE+LR+ IK+IWKRT LLD+VVPPAG +D+VTVGKFYATFLIQ+YFR+FKK
Sbjct: 1578 EGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQEYFRKFKK 1636
Query: 4570 RKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDE 4719
RKE G P+Q A++LQAGLRTLH+IGPE++RAISG+L + D+
Sbjct: 1637 RKEQGLVG-KPSQR-NALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDK 1684
Score = 708 bits (1827), Expect = 0.0
Identities = 372/668 (55%), Positives = 448/668 (66%), Gaps = 27/668 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR+ CISIVEWKPFE +IL I ANC+ALAIY P+P DS+ N+ LE +EY+F+++F
Sbjct: 111 NPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIF 170
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQ-----------G 549
T+E LK++A G +FHP+AYLRN WN+LDFIIVV+GL S IL + + G
Sbjct: 171 TVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAG 230
Query: 550 FDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELF 729
FDVKALRAFRVLRPLRLVSGVPSLQVVLN+I++AM+PLLHIALLVLFVI+IYAIIGLELF
Sbjct: 231 FDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELF 290
Query: 730 CGKLHSTCIDPA--TGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPG 903
GK+H TC + A++DP+PC +T G +CQ + ++ G W G
Sbjct: 291 MGKMHKTCYNQEGIIDVPAEEDPSPCALET-GHGRQCQ-NGTVCKPG----------WDG 338
Query: 904 PNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLN 1083
P +GITNFDNF AMLTVFQC+++EGWTDV+YW+ DA+G E PW+YFV+LVI GSFFVLN
Sbjct: 339 PKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLN 398
Query: 1084 LVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDE 1263
LVLGVLSGEFSKEREKA+ARG FQK REKQQLEEDLKGYLDWITQAEDI+P NEDE DE
Sbjct: 399 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDE 458
Query: 1264 --------PVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLE------KLNXXXXXXXX 1401
P ++T ++ A R+ + + + N
Sbjct: 459 DKPRNMSMPTSETESVNTENVAGGDIEGENCRARLAHRISKSKFSRYWRRWNRFCRRKCR 518
Query: 1402 XLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSL 1581
VKS FYW SEHY Q WL Q AN + LF+ EMLLKMYSL
Sbjct: 519 AAVKSNVFYWLVIFLVFLNTLTIASEHYNQPHWLTEVQDTANKALLALFTAEMLLKMYSL 578
Query: 1582 GFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXX 1761
G Y S FNRFDCF+V ILE +LV +M PLG+SVLR RLLRIFK+T+YW
Sbjct: 579 GLQAYFVSLFNRFDCFIVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 1762 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALL 1941
GMQ+FGGKFNF+ Q + R+ FD F Q+LL
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTR-RSTFDNFPQSLL 697
Query: 1942 TVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLA 2121
TVFQILTGEDWN+VMY GI ++GG G++VCIY+I+LFICGNYILLNVFLAIAVDNLA
Sbjct: 698 TVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLA 757
Query: 2122 DADSLTNA 2145
DA+SLT+A
Sbjct: 758 DAESLTSA 765
Score = 130 bits (327), Expect = 4e-28
Identities = 100/342 (29%), Positives = 162/342 (47%), Gaps = 10/342 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V NN R C IV F LILF I + I+L
Sbjct: 861 RPRPLSELHLKEKAVPMPEASAFFIFSPNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 920
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P Q + ++N +L +YVF +FT+E +LK+ A G H ++ RN +NILD +
Sbjct: 921 AAEDP--VQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLL 978
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S + +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 979 VVSVSLISFGIQSSAINV--VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIV 1036
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ-KDPTPCGTDTEGSAFKCQPSDSL 852
++ + ++A IG++LF GKL+ TC D + A+ K D E QP
Sbjct: 1037 IVTTLLQFMFACIGVQLFKGKLY-TCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRS-- 1093
Query: 853 TNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWP 1032
WE N +FDN AM+ +F + EGW +++Y D+ +
Sbjct: 1094 ------WE-----------NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKG 1136
Query: 1033 WIY---------FVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
IY F+ +I+ +FF++N+ +G + F ++ E+
Sbjct: 1137 PIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1178
Score = 95.5 bits (236), Expect = 1e-17
Identities = 63/259 (24%), Positives = 124/259 (47%), Gaps = 5/259 (1%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S F +++ ++ +NT+++A +HY + D N +F E +LK+ +L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPHWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD +V G ++ + + + I+ R R++R+ K+ +
Sbjct: 581 QAYFVSLFNRFDCFIVCGGILETIL--VETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + + S +++ + LL+ L I++++GMQ F GK D+ + R + F +FP ++
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT--RRSTFDNFPQSL 696
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNF----AYPYFISF 4044
L +F+ TGE W +M D G G +F YFI
Sbjct: 697 LTVFQILTGEDWNSVMY--------------DGIMAYG------GPSFPGMLVCIYFIIL 736
Query: 4045 FMLCSFLVINLFVAVIMDN 4101
F+ +++++N+F+A+ +DN
Sbjct: 737 FICGNYILLNVFLAIAVDN 755
Score = 87.8 bits (216), Expect = 3e-15
Identities = 74/273 (27%), Positives = 119/273 (43%), Gaps = 29/273 (10%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR--NMILNYF 2502
+L L+ N R C +V F +L I + LA P + + N L
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL----RTDAMS 2670
+Y F +FTVE LKVI +GL+FH ++ RN +NLLD ++V V L S +L + D +
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 2671 XXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
A ++ L+ V+ +I A+ + +I L+ + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 2824 AIIGVQLFKGTFF--------LCNDLSKMTEAECRGEYIH---YEDGDPTKPVSKKRVW- 2967
AIIG++LF G + + ++ + C E H ++G KP W
Sbjct: 283 AIIGLELFMGKMHKTCYNQEGIIDVPAEEDPSPCALETGHGRQCQNGTVCKP-----GWD 337
Query: 2968 --SNNDFNFDNVGDAMISLFVVSTFEGWPQLLY 3060
+ NFDN AM+++F T EGW +LY
Sbjct: 338 GPKHGITNFDNFAFAMLTVFQCITMEGWTDVLY 370
Score = 87.8 bits (216), Expect = 3e-15
Identities = 88/353 (24%), Positives = 144/353 (39%), Gaps = 54/353 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE +I L I N V+LA +P S L+ +F +F EA LK++A
Sbjct: 124 KPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGL 183
Query: 3511 -LNPKNYISDRWNVFD-LLVVVGSFIDITYGKLNPGGTNLIS-------INFFRLFRVMR 3663
+P Y+ + WN+ D ++VVVG F I G N + + R FRV+R
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLR 243
Query: 3664 LVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV--------- 3813
++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F GK+
Sbjct: 244 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEG 303
Query: 3814 -----ALDDSTSI------------------------HRNNNFHSFPAAILVLFRSATGE 3906
A +D + H NF +F A+L +F+ T E
Sbjct: 304 IIDVPAEEDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITME 363
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVA 4086
W D++ D G + YF+S + SF V+NL +
Sbjct: 364 GWTDVLYWMQD---------------------AMGYELPWVYFVSLVIFGSFFVLNLVLG 402
Query: 4087 VIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
V+ F G + +R + + D KG +LD +T I P
Sbjct: 403 VLSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 449
Score = 82.8 bits (203), Expect = 9e-14
Identities = 75/315 (23%), Positives = 131/315 (40%), Gaps = 33/315 (10%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+L+ +I N I LA+ Q Y Q +K + + +F +FT+E +LK++A F
Sbjct: 1224 FEYLMFVLILLNTICLAM-QHY-GQSCLFK-IAMNILNMLFTGLFTVEMILKLIA----F 1276
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSK------------MSIQG---FDVKALRAFRV 582
P Y +AWN D +IVV +V +++ MS + + R FRV
Sbjct: 1277 KPKHYFCDAWNTFDALIVVGSIVDIAITEVHPAEHTQCSPSMSAEENSRISITFFRLFRV 1336
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
+R ++L+S ++ +L +++ L ++ALL++ + IYA+IG+++F
Sbjct: 1337 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF----------- 1385
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
G++A D T N NF F
Sbjct: 1386 --GKIALNDTTEI------------------------------------NRNNNFQTFPQ 1407
Query: 943 AMLTVFQCVSLEGWTDVMYWV------------------NDAVGREWPWIYFVTLVILGS 1068
A+L +F+C + E W D+M G + YF++ +L +
Sbjct: 1408 AVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTKGETPCGSSFAVFYFISFYMLCA 1467
Query: 1069 FFVLNLVLGVLSGEF 1113
F ++NL + V+ F
Sbjct: 1468 FLIINLFVAVIMDNF 1482
Score = 69.7 bits (169), Expect = 8e-10
Identities = 55/240 (22%), Positives = 95/240 (38%), Gaps = 27/240 (11%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HYGQS + N+ F LF++EM+LK+ + Y +N FD +V+ SI++
Sbjct: 1242 QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDI 1301
Query: 1657 VLVYF--------------DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXX 1794
+ + + ++ R R++R+ K+
Sbjct: 1302 AITEVHPAEHTQCSPSMSAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQ 1361
Query: 1795 XXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDW 1974
GMQVFG + + NF TF QA+L +F+ TGE W
Sbjct: 1362 ALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAW 1421
Query: 1975 NTVMYHGI-------ESFGGVGTLGVIVC------IYYIVLFICGNYILLNVFLAIAVDN 2115
+M + ES T G C Y+I ++ ++++N+F+A+ +DN
Sbjct: 1422 QDIMLACMPGKKCAPESEPSNSTKGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDN 1481
Score = 43.1 bits (100), Expect = 0.077
Identities = 47/240 (19%), Positives = 88/240 (36%), Gaps = 38/240 (15%)
Frame = +1
Query: 1504 DHFQTMANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYF 1671
+H A+ F +F++E++LKM + G ++ + FN D VV S++ F +
Sbjct: 933 NHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS 992
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+ V +LR R+LR +
Sbjct: 993 AINV---VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACI 1049
Query: 1852 GMQVFGGKFNFNPQQPK------------------------PRA------NFDTFVQALL 1941
G+Q+F GK K PR+ +FD + A++
Sbjct: 1050 GVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMM 1109
Query: 1942 TVFQILTGEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+F + T E W ++Y I+S G + V + I++I+ I + ++N+F+ +
Sbjct: 1110 ALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1169
>gi|281054|pir||JH0427 voltage-dependent calcium channel complex
alpha-1 chain rbC-II - rat
Length = 2143
Score = 1021 bits (2639), Expect = 0.0
Identities = 509/830 (61%), Positives = 639/830 (76%), Gaps = 12/830 (1%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPR +SE+ P+P+AS+ FI S N FR+ C+ +VN + FTN +LF IL+SS L
Sbjct: 861 RPRPLSELHLKEKAVPMPEASAFFIFSPNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 920
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP+Q S RN IL DY FTS+FT+EI LK+ +G HKGSFCRN FN+LD+LVV
Sbjct: 921 AAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVV 980
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
+VSL SF +++ A++ AINRAKGLKHVVQCV VA++TIGNI++VT
Sbjct: 981 SVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 1040
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG + C+D SK TEAEC+G YI Y+DG+ P+ + R W N+ F+
Sbjct: 1041 LLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFD 1100
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP+LLY +IDS+ EDKGPI+N R +++
Sbjct: 1101 FDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFM 1160
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N+ QY+VW+ V
Sbjct: 1161 MNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVN 1220
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S F+ +++ N++FTG+F E +LK++A PK+
Sbjct: 1221 STYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKH 1280
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGG------------TNLISINFFRLFRVMRLV 3669
Y D WN FD L+VVGS +DI +++P + ISI FFRLFRVMRLV
Sbjct: 1281 YFCDAWNTFDALIVVGSIVDIAITEVHPAEHTQCSPSMSAEENSRISITFFRLFRVMRLV 1340
Query: 3670 KLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNN 3849
KLLSRGEGIRTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL+D+T I+RNN
Sbjct: 1341 KLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNN 1400
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FP A+L+LFR ATGEAWQDIML+C + +C P S+ + E+ CG++FA
Sbjct: 1401 NFQTFPQAVLLLFRCATGEAWQDIMLACMPGK--KCAPESEPSNSTE-GETPCGSSFAVF 1457
Query: 4030 YFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKH 4209
YFISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+W+EYDP+AKGRIKH
Sbjct: 1458 YFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKH 1517
Query: 4210 LDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYT 4389
LDVVTLLR+I PPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFALVRT L+I T
Sbjct: 1518 LDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKT 1577
Query: 4390 EGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKK 4569
EGN+++ANE+LR+ IK+IWKRT LLD+VVPPAG +D+VTVGKFYATFLIQ+YFR+FKK
Sbjct: 1578 EGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQEYFRKFKK 1636
Query: 4570 RKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDE 4719
RKE G P+Q A++LQAGLRTLH+IGPE++RAISG+L + D+
Sbjct: 1637 RKEQGLVG-KPSQR-NALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDK 1684
Score = 708 bits (1827), Expect = 0.0
Identities = 372/668 (55%), Positives = 448/668 (66%), Gaps = 27/668 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR+ CISIVEWKPFE +IL I ANC+ALAIY P+P DS+ N+ LE +EY+F+++F
Sbjct: 111 NPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIF 170
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQ-----------G 549
T+E LK++A G +FHP+AYLRN WN+LDFIIVV+GL S IL + + G
Sbjct: 171 TVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAG 230
Query: 550 FDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELF 729
FDVKALRAFRVLRPLRLVSGVPSLQVVLN+I++AM+PLLHIALLVLFVI+IYAIIGLELF
Sbjct: 231 FDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELF 290
Query: 730 CGKLHSTCIDPA--TGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPG 903
GK+H TC + A++DP+PC +T G +CQ + ++ G W G
Sbjct: 291 MGKMHKTCYNQEGIIDVPAEEDPSPCALET-GHGRQCQ-NGTVCKPG----------WDG 338
Query: 904 PNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLN 1083
P +GITNFDNF AMLTVFQC+++EGWTDV+YW+ DA+G E PW+YFV+LVI GSFFVLN
Sbjct: 339 PKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLN 398
Query: 1084 LVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDE 1263
LVLGVLSGEFSKEREKA+ARG FQK REKQQLEEDLKGYLDWITQAEDI+P NEDE DE
Sbjct: 399 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDE 458
Query: 1264 --------PVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLE------KLNXXXXXXXX 1401
P ++T ++ A R+ + + + N
Sbjct: 459 DKPRNMSMPTSETESVNTENVAGGDIEGENCRARLAHRISKSKFSRYWRRWNRFCRRKCR 518
Query: 1402 XLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSL 1581
VKS FYW SEHY Q WL Q AN + LF+ EMLLKMYSL
Sbjct: 519 AAVKSNVFYWLVIFLVFLNTLTIASEHYNQPHWLTEVQDTANKALLALFTAEMLLKMYSL 578
Query: 1582 GFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXX 1761
G Y S FNRFDCF+V ILE +LV +M PLG+SVLR RLLRIFK+T+YW
Sbjct: 579 GLQAYFVSLFNRFDCFIVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 1762 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALL 1941
GMQ+FGGKFNF+ Q + R+ FD F Q+LL
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTR-RSTFDNFPQSLL 697
Query: 1942 TVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLA 2121
TVFQILTGEDWN+VMY GI ++GG G++VCIY+I+LFICGNYILLNVFLAIAVDNLA
Sbjct: 698 TVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLA 757
Query: 2122 DADSLTNA 2145
DA+SLT+A
Sbjct: 758 DAESLTSA 765
Score = 130 bits (327), Expect = 4e-28
Identities = 100/342 (29%), Positives = 162/342 (47%), Gaps = 10/342 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V NN R C IV F LILF I + I+L
Sbjct: 861 RPRPLSELHLKEKAVPMPEASAFFIFSPNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 920
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P Q + ++N +L +YVF +FT+E +LK+ A G H ++ RN +NILD +
Sbjct: 921 AAEDP--VQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLL 978
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S + +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 979 VVSVSLISFGIQSSAINV--VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIV 1036
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ-KDPTPCGTDTEGSAFKCQPSDSL 852
++ + ++A IG++LF GKL+ TC D + A+ K D E QP
Sbjct: 1037 IVTTLLQFMFACIGVQLFKGKLY-TCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRS-- 1093
Query: 853 TNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWP 1032
WE N +FDN AM+ +F + EGW +++Y D+ +
Sbjct: 1094 ------WE-----------NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKG 1136
Query: 1033 WIY---------FVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
IY F+ +I+ +FF++N+ +G + F ++ E+
Sbjct: 1137 PIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1178
Score = 95.5 bits (236), Expect = 1e-17
Identities = 63/259 (24%), Positives = 124/259 (47%), Gaps = 5/259 (1%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S F +++ ++ +NT+++A +HY + D N +F E +LK+ +L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPHWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD +V G ++ + + + I+ R R++R+ K+ +
Sbjct: 581 QAYFVSLFNRFDCFIVCGGILETIL--VETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + + S +++ + LL+ L I++++GMQ F GK D+ + R + F +FP ++
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT--RRSTFDNFPQSL 696
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNF----AYPYFISF 4044
L +F+ TGE W +M D G G +F YFI
Sbjct: 697 LTVFQILTGEDWNSVMY--------------DGIMAYG------GPSFPGMLVCIYFIIL 736
Query: 4045 FMLCSFLVINLFVAVIMDN 4101
F+ +++++N+F+A+ +DN
Sbjct: 737 FICGNYILLNVFLAIAVDN 755
Score = 87.8 bits (216), Expect = 3e-15
Identities = 74/273 (27%), Positives = 119/273 (43%), Gaps = 29/273 (10%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR--NMILNYF 2502
+L L+ N R C +V F +L I + LA P + + N L
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL----RTDAMS 2670
+Y F +FTVE LKVI +GL+FH ++ RN +NLLD ++V V L S +L + D +
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 2671 XXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
A ++ L+ V+ +I A+ + +I L+ + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 2824 AIIGVQLFKGTFF--------LCNDLSKMTEAECRGEYIH---YEDGDPTKPVSKKRVW- 2967
AIIG++LF G + + ++ + C E H ++G KP W
Sbjct: 283 AIIGLELFMGKMHKTCYNQEGIIDVPAEEDPSPCALETGHGRQCQNGTVCKP-----GWD 337
Query: 2968 --SNNDFNFDNVGDAMISLFVVSTFEGWPQLLY 3060
+ NFDN AM+++F T EGW +LY
Sbjct: 338 GPKHGITNFDNFAFAMLTVFQCITMEGWTDVLY 370
Score = 87.8 bits (216), Expect = 3e-15
Identities = 88/353 (24%), Positives = 144/353 (39%), Gaps = 54/353 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE +I L I N V+LA +P S L+ +F +F EA LK++A
Sbjct: 124 KPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGL 183
Query: 3511 -LNPKNYISDRWNVFD-LLVVVGSFIDITYGKLNPGGTNLIS-------INFFRLFRVMR 3663
+P Y+ + WN+ D ++VVVG F I G N + + R FRV+R
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLR 243
Query: 3664 LVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV--------- 3813
++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F GK+
Sbjct: 244 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEG 303
Query: 3814 -----ALDDSTSI------------------------HRNNNFHSFPAAILVLFRSATGE 3906
A +D + H NF +F A+L +F+ T E
Sbjct: 304 IIDVPAEEDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITME 363
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVA 4086
W D++ D G + YF+S + SF V+NL +
Sbjct: 364 GWTDVLYWMQD---------------------AMGYELPWVYFVSLVIFGSFFVLNLVLG 402
Query: 4087 VIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
V+ F G + +R + + D KG +LD +T I P
Sbjct: 403 VLSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 449
Score = 82.8 bits (203), Expect = 9e-14
Identities = 75/315 (23%), Positives = 131/315 (40%), Gaps = 33/315 (10%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+L+ +I N I LA+ Q Y Q +K + + +F +FT+E +LK++A F
Sbjct: 1224 FEYLMFVLILLNTICLAM-QHY-GQSCLFK-IAMNILNMLFTGLFTVEMILKLIA----F 1276
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSK------------MSIQG---FDVKALRAFRV 582
P Y +AWN D +IVV +V +++ MS + + R FRV
Sbjct: 1277 KPKHYFCDAWNTFDALIVVGSIVDIAITEVHPAEHTQCSPSMSAEENSRISITFFRLFRV 1336
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
+R ++L+S ++ +L +++ L ++ALL++ + IYA+IG+++F
Sbjct: 1337 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF----------- 1385
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
G++A D T N NF F
Sbjct: 1386 --GKIALNDTTEI------------------------------------NRNNNFQTFPQ 1407
Query: 943 AMLTVFQCVSLEGWTDVMYWV------------------NDAVGREWPWIYFVTLVILGS 1068
A+L +F+C + E W D+M G + YF++ +L +
Sbjct: 1408 AVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCA 1467
Query: 1069 FFVLNLVLGVLSGEF 1113
F ++NL + V+ F
Sbjct: 1468 FLIINLFVAVIMDNF 1482
Score = 69.3 bits (168), Expect = 1e-09
Identities = 55/240 (22%), Positives = 95/240 (38%), Gaps = 27/240 (11%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HYGQS + N+ F LF++EM+LK+ + Y +N FD +V+ SI++
Sbjct: 1242 QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDI 1301
Query: 1657 VLVYF--------------DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXX 1794
+ + + ++ R R++R+ K+
Sbjct: 1302 AITEVHPAEHTQCSPSMSAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQ 1361
Query: 1795 XXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDW 1974
GMQVFG + + NF TF QA+L +F+ TGE W
Sbjct: 1362 ALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAW 1421
Query: 1975 NTVMYHGI-------ESFGGVGTLGVIVC------IYYIVLFICGNYILLNVFLAIAVDN 2115
+M + ES T G C Y+I ++ ++++N+F+A+ +DN
Sbjct: 1422 QDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDN 1481
Score = 43.1 bits (100), Expect = 0.077
Identities = 47/240 (19%), Positives = 88/240 (36%), Gaps = 38/240 (15%)
Frame = +1
Query: 1504 DHFQTMANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYF 1671
+H A+ F +F++E++LKM + G ++ + FN D VV S++ F +
Sbjct: 933 NHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS 992
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+ V +LR R+LR +
Sbjct: 993 AINV---VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACI 1049
Query: 1852 GMQVFGGKFNFNPQQPK------------------------PRA------NFDTFVQALL 1941
G+Q+F GK K PR+ +FD + A++
Sbjct: 1050 GVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMM 1109
Query: 1942 TVFQILTGEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+F + T E W ++Y I+S G + V + I++I+ I + ++N+F+ +
Sbjct: 1110 ALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1169
>gi|17864836|gb|AAL47071.1| L-type calcium channel alpha-1c subunit
[Rattus norvegicus]
Length = 2170
Score = 1021 bits (2639), Expect = 0.0
Identities = 509/830 (61%), Positives = 639/830 (76%), Gaps = 12/830 (1%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPR +SE+ P+P+AS+ FI S N FR+ C+ +VN + FTN +LF IL+SS L
Sbjct: 888 RPRPLSELHLKEKAVPMPEASAFFIFSPNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 947
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP+Q S RN IL DY FTS+FT+EI LK+ +G HKGSFCRN FN+LD+LVV
Sbjct: 948 AAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVV 1007
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
+VSL SF +++ A++ AINRAKGLKHVVQCV VA++TIGNI++VT
Sbjct: 1008 SVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 1067
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG + C+D SK TEAEC+G YI Y+DG+ P+ + R W N+ F+
Sbjct: 1068 LLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFD 1127
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP+LLY +IDS+ EDKGPI+N R +++
Sbjct: 1128 FDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFM 1187
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N+ QY+VW+ V
Sbjct: 1188 MNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVN 1247
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S F+ +++ N++FTG+F E +LK++A PK+
Sbjct: 1248 STYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKH 1307
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGG------------TNLISINFFRLFRVMRLV 3669
Y D WN FD L+VVGS +DI +++P + ISI FFRLFRVMRLV
Sbjct: 1308 YFCDAWNTFDALIVVGSIVDIAITEVHPAEHTQCSPSMSAEENSRISITFFRLFRVMRLV 1367
Query: 3670 KLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNN 3849
KLLSRGEGIRTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL+D+T I+RNN
Sbjct: 1368 KLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNN 1427
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FP A+L+LFR ATGEAWQDIML+C + +C P S+ + E+ CG++FA
Sbjct: 1428 NFQTFPQAVLLLFRCATGEAWQDIMLACMPGK--KCAPESEPSNSTE-GETPCGSSFAVF 1484
Query: 4030 YFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKH 4209
YFISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+W+EYDP+AKGRIKH
Sbjct: 1485 YFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKH 1544
Query: 4210 LDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYT 4389
LDVVTLLR+I PPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFALVRT L+I T
Sbjct: 1545 LDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKT 1604
Query: 4390 EGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKK 4569
EGN+++ANE+LR+ IK+IWKRT LLD+VVPPAG +D+VTVGKFYATFLIQ+YFR+FKK
Sbjct: 1605 EGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQEYFRKFKK 1663
Query: 4570 RKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDE 4719
RKE G P+Q A++LQAGLRTLH+IGPE++RAISG+L + D+
Sbjct: 1664 RKEQGLVG-KPSQR-NALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDK 1711
Score = 708 bits (1827), Expect = 0.0
Identities = 372/668 (55%), Positives = 448/668 (66%), Gaps = 27/668 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR+ CISIVEWKPFE +IL I ANC+ALAIY P+P DS+ N+ LE +EY+F+++F
Sbjct: 141 NPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIF 200
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQ-----------G 549
T+E LK++A G +FHP+AYLRN WN+LDFIIVV+GL S IL + + G
Sbjct: 201 TVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAG 260
Query: 550 FDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELF 729
FDVKALRAFRVLRPLRLVSGVPSLQVVLN+I++AM+PLLHIALLVLFVI+IYAIIGLELF
Sbjct: 261 FDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELF 320
Query: 730 CGKLHSTCIDPA--TGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPG 903
GK+H TC + A++DP+PC +T G +CQ + ++ G W G
Sbjct: 321 MGKMHKTCYNQEGIIDVPAEEDPSPCALET-GHGRQCQ-NGTVCKPG----------WDG 368
Query: 904 PNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLN 1083
P +GITNFDNF AMLTVFQC+++EGWTDV+YW+ DA+G E PW+YFV+LVI GSFFVLN
Sbjct: 369 PKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLN 428
Query: 1084 LVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDE 1263
LVLGVLSGEFSKEREKA+ARG FQK REKQQLEEDLKGYLDWITQAEDI+P NEDE DE
Sbjct: 429 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDE 488
Query: 1264 --------PVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLE------KLNXXXXXXXX 1401
P ++T ++ A R+ + + + N
Sbjct: 489 DKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCR 548
Query: 1402 XLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSL 1581
VKS FYW SEHY Q WL Q AN + LF+ EMLLKMYSL
Sbjct: 549 AAVKSNVFYWLVIFLVFLNTLTIASEHYNQPHWLTEVQDTANKALLALFTAEMLLKMYSL 608
Query: 1582 GFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXX 1761
G Y S FNRFDCF+V ILE +LV +M PLG+SVLR RLLRIFK+T+YW
Sbjct: 609 GLQAYFVSLFNRFDCFIVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 668
Query: 1762 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALL 1941
GMQ+FGGKFNF+ Q + R+ FD F Q+LL
Sbjct: 669 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTR-RSTFDNFPQSLL 727
Query: 1942 TVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLA 2121
TVFQILTGEDWN+VMY GI ++GG G++VCIY+I+LFICGNYILLNVFLAIAVDNLA
Sbjct: 728 TVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLA 787
Query: 2122 DADSLTNA 2145
DA+SLT+A
Sbjct: 788 DAESLTSA 795
Score = 130 bits (327), Expect = 4e-28
Identities = 100/342 (29%), Positives = 162/342 (47%), Gaps = 10/342 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V NN R C IV F LILF I + I+L
Sbjct: 888 RPRPLSELHLKEKAVPMPEASAFFIFSPNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 947
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P Q + ++N +L +YVF +FT+E +LK+ A G H ++ RN +NILD +
Sbjct: 948 AAEDP--VQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLL 1005
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S + +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 1006 VVSVSLISFGIQSSAINV--VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIV 1063
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ-KDPTPCGTDTEGSAFKCQPSDSL 852
++ + ++A IG++LF GKL+ TC D + A+ K D E QP
Sbjct: 1064 IVTTLLQFMFACIGVQLFKGKLY-TCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRS-- 1120
Query: 853 TNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWP 1032
WE N +FDN AM+ +F + EGW +++Y D+ +
Sbjct: 1121 ------WE-----------NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKG 1163
Query: 1033 WIY---------FVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
IY F+ +I+ +FF++N+ +G + F ++ E+
Sbjct: 1164 PIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1205
Score = 95.5 bits (236), Expect = 1e-17
Identities = 63/259 (24%), Positives = 124/259 (47%), Gaps = 5/259 (1%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S F +++ ++ +NT+++A +HY + D N +F E +LK+ +L
Sbjct: 551 VKSNVFYWLVIFLVFLNTLTIASEHYNQPHWLTEVQDTANKALLALFTAEMLLKMYSLGL 610
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD +V G ++ + + + I+ R R++R+ K+ +
Sbjct: 611 QAYFVSLFNRFDCFIVCGGILETIL--VETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 668
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + + S +++ + LL+ L I++++GMQ F GK D+ + R + F +FP ++
Sbjct: 669 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT--RRSTFDNFPQSL 726
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNF----AYPYFISF 4044
L +F+ TGE W +M D G G +F YFI
Sbjct: 727 LTVFQILTGEDWNSVMY--------------DGIMAYG------GPSFPGMLVCIYFIIL 766
Query: 4045 FMLCSFLVINLFVAVIMDN 4101
F+ +++++N+F+A+ +DN
Sbjct: 767 FICGNYILLNVFLAIAVDN 785
Score = 87.8 bits (216), Expect = 3e-15
Identities = 74/273 (27%), Positives = 119/273 (43%), Gaps = 29/273 (10%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR--NMILNYF 2502
+L L+ N R C +V F +L I + LA P + + N L
Sbjct: 133 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 192
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL----RTDAMS 2670
+Y F +FTVE LKVI +GL+FH ++ RN +NLLD ++V V L S +L + D +
Sbjct: 193 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 252
Query: 2671 XXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
A ++ L+ V+ +I A+ + +I L+ + ++
Sbjct: 253 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 312
Query: 2824 AIIGVQLFKGTFF--------LCNDLSKMTEAECRGEYIH---YEDGDPTKPVSKKRVW- 2967
AIIG++LF G + + ++ + C E H ++G KP W
Sbjct: 313 AIIGLELFMGKMHKTCYNQEGIIDVPAEEDPSPCALETGHGRQCQNGTVCKP-----GWD 367
Query: 2968 --SNNDFNFDNVGDAMISLFVVSTFEGWPQLLY 3060
+ NFDN AM+++F T EGW +LY
Sbjct: 368 GPKHGITNFDNFAFAMLTVFQCITMEGWTDVLY 400
Score = 87.8 bits (216), Expect = 3e-15
Identities = 88/353 (24%), Positives = 144/353 (39%), Gaps = 54/353 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE +I L I N V+LA +P S L+ +F +F EA LK++A
Sbjct: 154 KPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGL 213
Query: 3511 -LNPKNYISDRWNVFD-LLVVVGSFIDITYGKLNPGGTNLIS-------INFFRLFRVMR 3663
+P Y+ + WN+ D ++VVVG F I G N + + R FRV+R
Sbjct: 214 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLR 273
Query: 3664 LVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV--------- 3813
++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F GK+
Sbjct: 274 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEG 333
Query: 3814 -----ALDDSTSI------------------------HRNNNFHSFPAAILVLFRSATGE 3906
A +D + H NF +F A+L +F+ T E
Sbjct: 334 IIDVPAEEDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITME 393
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVA 4086
W D++ D G + YF+S + SF V+NL +
Sbjct: 394 GWTDVLYWMQD---------------------AMGYELPWVYFVSLVIFGSFFVLNLVLG 432
Query: 4087 VIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
V+ F G + +R + + D KG +LD +T I P
Sbjct: 433 VLSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 479
Score = 82.8 bits (203), Expect = 9e-14
Identities = 75/315 (23%), Positives = 131/315 (40%), Gaps = 33/315 (10%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+L+ +I N I LA+ Q Y Q +K + + +F +FT+E +LK++A F
Sbjct: 1251 FEYLMFVLILLNTICLAM-QHY-GQSCLFK-IAMNILNMLFTGLFTVEMILKLIA----F 1303
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSK------------MSIQG---FDVKALRAFRV 582
P Y +AWN D +IVV +V +++ MS + + R FRV
Sbjct: 1304 KPKHYFCDAWNTFDALIVVGSIVDIAITEVHPAEHTQCSPSMSAEENSRISITFFRLFRV 1363
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
+R ++L+S ++ +L +++ L ++ALL++ + IYA+IG+++F
Sbjct: 1364 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF----------- 1412
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
G++A D T N NF F
Sbjct: 1413 --GKIALNDTTEI------------------------------------NRNNNFQTFPQ 1434
Query: 943 AMLTVFQCVSLEGWTDVMYWV------------------NDAVGREWPWIYFVTLVILGS 1068
A+L +F+C + E W D+M G + YF++ +L +
Sbjct: 1435 AVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCA 1494
Query: 1069 FFVLNLVLGVLSGEF 1113
F ++NL + V+ F
Sbjct: 1495 FLIINLFVAVIMDNF 1509
Score = 69.3 bits (168), Expect = 1e-09
Identities = 55/240 (22%), Positives = 95/240 (38%), Gaps = 27/240 (11%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HYGQS + N+ F LF++EM+LK+ + Y +N FD +V+ SI++
Sbjct: 1269 QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDI 1328
Query: 1657 VLVYF--------------DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXX 1794
+ + + ++ R R++R+ K+
Sbjct: 1329 AITEVHPAEHTQCSPSMSAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQ 1388
Query: 1795 XXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDW 1974
GMQVFG + + NF TF QA+L +F+ TGE W
Sbjct: 1389 ALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAW 1448
Query: 1975 NTVMYHGI-------ESFGGVGTLGVIVC------IYYIVLFICGNYILLNVFLAIAVDN 2115
+M + ES T G C Y+I ++ ++++N+F+A+ +DN
Sbjct: 1449 QDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDN 1508
Score = 43.1 bits (100), Expect = 0.077
Identities = 47/240 (19%), Positives = 88/240 (36%), Gaps = 38/240 (15%)
Frame = +1
Query: 1504 DHFQTMANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYF 1671
+H A+ F +F++E++LKM + G ++ + FN D VV S++ F +
Sbjct: 960 NHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS 1019
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+ V +LR R+LR +
Sbjct: 1020 AINV---VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACI 1076
Query: 1852 GMQVFGGKFNFNPQQPK------------------------PRA------NFDTFVQALL 1941
G+Q+F GK K PR+ +FD + A++
Sbjct: 1077 GVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMM 1136
Query: 1942 TVFQILTGEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+F + T E W ++Y I+S G + V + I++I+ I + ++N+F+ +
Sbjct: 1137 ALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1196
>gi|50729014|ref|XP_416388.1| PREDICTED: similar to L-type calcium
channel alpha 1 subunit [Gallus gallus]
Length = 2557
Score = 1020 bits (2638), Expect = 0.0
Identities = 514/850 (60%), Positives = 642/850 (75%), Gaps = 32/850 (3%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPR MSE+ P+P AS+ FI S N FRV C+ +VN + FTN +LF IL+SS L
Sbjct: 1180 RPRPMSELHLKEKAVPMPDASAFFIFSPNNRFRVHCHRIVNDNIFTNLILFFILLSSISL 1239
Query: 2446 AAEDPLQANSTRNMILNYFD--------------------YFFTSVFTVEITLKVIVFGL 2565
AAEDP++ S RN +L YFD Y FTS+FT+EI LK+ +G
Sbjct: 1240 AAEDPVRHLSFRNQVLFYFDIVFTVIFTIEIALKILGNADYVFTSIFTLEIILKMTAYGA 1299
Query: 2566 VFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKH 2745
HKGSFCRN FN+LD+LVV+VSL SF +++ A++ AINRAKGLKH
Sbjct: 1300 FLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKH 1359
Query: 2746 VVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYE 2925
VVQCV VA++TIGNI++VT +LQFMFA IGVQLFKG + C D SK TEAECRG YI Y+
Sbjct: 1360 VVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYSCTDSSKQTEAECRGYYITYK 1419
Query: 2926 DGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHN 3105
DG+ ++P+ + R W N+ F+FDNV AM++LF VSTFEGWP+LLY +IDS+ ED GPI+N
Sbjct: 1420 DGEVSQPMIQPRSWENSKFDFDNVLTAMMALFTVSTFEGWPELLYRSIDSHMEDVGPIYN 1479
Query: 3106 SRQAVALXXXXXXXXXXXXXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAK 3285
R +++ GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+
Sbjct: 1480 HRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKAR 1539
Query: 3286 PHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLI 3465
P RRYIP+N+ QY+VW+ V S FEY++F++I++NT+ LA +HY S F++ +++ N++
Sbjct: 1540 PLRRYIPKNQYQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCMFKEAMNILNML 1599
Query: 3466 FTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGT--------- 3618
FTG+F E VLK++A PK+Y D WN FD L+VVGS +DI ++NP
Sbjct: 1600 FTGLFTVEMVLKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAENTQCSSSMNA 1659
Query: 3619 ---NLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVI 3789
+ ISI FFRLFRVMRLVKLLSRGEGIRTLLWTF+KSFQALPYVALLIV+LFFIYAVI
Sbjct: 1660 EENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVI 1719
Query: 3790 GMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMS 3969
GMQ FGK+AL+D+T I+RNNNF +FP A+L+LFR ATGEAWQ+IML+C D +CDP S
Sbjct: 1720 GMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLP--DKKCDPDS 1777
Query: 3970 DDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHL 4149
+ + + S CG++FA YFISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL
Sbjct: 1778 EPANSTEADHS-CGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHL 1836
Query: 4150 EEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDG 4329
+EF R+W+EYDP+AKGRIKHLDVVTLLR+I PPLGFGKLCPHR+ACKRLVSMNMPLNSDG
Sbjct: 1837 DEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDG 1896
Query: 4330 TVCFNATLFALVRTNLKIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDV 4509
TV FNATLFALVRT L+I TEGN+++ANE+LR+ IK+IWKRT LLD+VVPPAG +D+V
Sbjct: 1897 TVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAG-DDEV 1955
Query: 4510 TVGKFYATFLIQDYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISG 4689
TVGKFYATFLIQ+YFR+FKKRKE G P+Q A++LQAGLRTLH+IGPE++RAISG
Sbjct: 1956 TVGKFYATFLIQEYFRKFKKRKEQGLVG-KPSQR-NALSLQAGLRTLHDIGPEIRRAISG 2013
Query: 4690 NLETDFNFDE 4719
+L + D+
Sbjct: 2014 DLTAEEELDK 2023
Score = 590 bits (1520), Expect = e-166
Identities = 328/686 (47%), Positives = 397/686 (57%), Gaps = 93/686 (13%)
Frame = +1
Query: 295 CANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNA 474
C C +L + +P+ E +EY+F+++FT+E LK++A G +FHP+AYLRN
Sbjct: 339 CTKCESLTVIEPW------------ERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNG 386
Query: 475 WNILDFIIVVIGLVST---------ILSKMSIQ--------------------------- 546
WN+LDFIIVV+GL S L K+S Q
Sbjct: 387 WNLLDFIIVVVGLPSKPDRMHVHHETLPKLSFQSTQGRERTFICQRADRLFSAILEQATK 446
Query: 547 ------------GFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLF 690
GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+I++AM+PLLHIALLVLF
Sbjct: 447 ADGGNSIGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLF 506
Query: 691 VILIYAIIGLELFCGKLHSTCIDPATGQL---AQKDPTPCGTDTEGSAFKCQPSDSLTNM 861
VI+IYAIIGLELF GK+H TC G + A+ DP+PC + +CQ
Sbjct: 507 VIIIYAIIGLELFMGKMHKTCYHVQGGLIDTPAEDDPSPCAPQSAHGR-QCQNGT----- 560
Query: 862 GVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYW------------- 1002
EC + W GP +GITNFDNF AMLTVFQC+++EGWTDV+YW
Sbjct: 561 ----ECKAG--WEGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVY 614
Query: 1003 ---------------VNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKAR 1137
VNDA+GR+WPWIYFVTL+I+GSFFVLNLVLGVLSGEFSKEREKA+
Sbjct: 615 FVSLVIFGSFFVLNLVNDAIGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAK 674
Query: 1138 ARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDE--------PVAQTXXXXX 1293
ARG FQK REKQQLEEDLKGYLDWITQAEDI+P NEDE DE P ++T
Sbjct: 675 ARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNT 734
Query: 1294 XXXXXXXXXXXXXPSKWAARMKRLE------KLNXXXXXXXXXLVKSQTFYWXXXXXXXX 1455
++ A R+ + + + N VKS FYW
Sbjct: 735 DNVPGTDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFL 794
Query: 1456 XXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVV 1635
SEHY Q +WL Q AN + LF+ EMLLKMYSLG Y S FNRFDCF+V
Sbjct: 795 NTLTIASEHYNQPDWLTEVQDTANKVLLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFIV 854
Query: 1636 ISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXX 1815
ILE +LV +M PLG+SVLR RLLRIFK+T+YW
Sbjct: 855 CGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLL 914
Query: 1816 XXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHG 1995
GMQ+FGGKFNF+ Q + R+ FD F Q+LLTVFQILTGEDWN+VMY G
Sbjct: 915 LLFLFIIIFSLLGMQLFGGKFNFDEMQTR-RSTFDNFPQSLLTVFQILTGEDWNSVMYDG 973
Query: 1996 IESFGGVGTLGVIVCIYYIVLFICGN 2073
I ++GG G++VCIY+I+LFICGN
Sbjct: 974 IMAYGGPSFPGMLVCIYFIILFICGN 999
Score = 119 bits (298), Expect = 8e-25
Identities = 104/362 (28%), Positives = 167/362 (45%), Gaps = 30/362 (8%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V NN R C IV F LILF I + I+L
Sbjct: 1180 RPRPMSELHLKEKAVPMPDASAFFIFSPNNRFRVHCHRIVNDNIFTNLILFFILLSSISL 1239
Query: 316 AIYQPYPAQDSDYKN----------TLLETIE----------YVFIVVFTIECVLKIVAM 435
A P + ++N T++ TIE YVF +FT+E +LK+ A
Sbjct: 1240 AAEDP--VRHLSFRNQVLFYFDIVFTVIFTIEIALKILGNADYVFTSIFTLEIILKMTAY 1297
Query: 436 GFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVP 615
G H ++ RN +NILD ++V + L+S + +I VK LR RVLRPLR ++
Sbjct: 1298 GAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAIN--VVKILRVLRVLRPLRAINRAK 1355
Query: 616 SLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ-KDP 792
L+ V+ + A+ + +I ++ + ++A IG++LF GKL+S C D + A+ +
Sbjct: 1356 GLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYS-CTDSSKQTEAECRGY 1414
Query: 793 TPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVS 972
D E S QP WE N +FDN AM+ +F +
Sbjct: 1415 YITYKDGEVSQPMIQPRS--------WE-----------NSKFDFDNVLTAMMALFTVST 1455
Query: 973 LEGWTDVMYWVNDA----VG-----REWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKER 1125
EGW +++Y D+ VG R I+F+ +I+ +FF++N+ +G + F ++
Sbjct: 1456 FEGWPELLYRSIDSHMEDVGPIYNHRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQG 1515
Query: 1126 EK 1131
E+
Sbjct: 1516 EQ 1517
Score = 91.7 bits (226), Expect = 2e-16
Identities = 50/196 (25%), Positives = 101/196 (51%), Gaps = 1/196 (0%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S F +++ ++ +NT+++A +HY + D N + +F E +LK+ +L
Sbjct: 779 VKSNVFYWLVIFLVFLNTLTIASEHYNQPDWLTEVQDTANKVLLALFTAEMLLKMYSLGL 838
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD +V G ++ + + + I+ R R++R+ K+ +
Sbjct: 839 QAYFVSLFNRFDCFIVCGGILETIL--VETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 896
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + + S +++ + LL+ L I++++GMQ F GK D+ + R + F +FP ++
Sbjct: 897 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT--RRSTFDNFPQSL 954
Query: 3877 LVLFRSATGEAWQDIM 3924
L +F+ TGE W +M
Sbjct: 955 LTVFQILTGEDWNSVM 970
Score = 84.3 bits (207), Expect = 3e-14
Identities = 73/315 (23%), Positives = 132/315 (41%), Gaps = 33/315 (10%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+L+ +I N I LA+ Q Y Q +K + + +F +FT+E VLK++A F
Sbjct: 1563 FEYLMFVLILLNTICLAM-QHY-GQSCMFKEAM-NILNMLFTGLFTVEMVLKLIA----F 1615
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMSI---------------QGFDVKALRAFRV 582
P Y +AWN D +IVV +V +++++ + R FRV
Sbjct: 1616 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAENTQCSSSMNAEENSRISITFFRLFRV 1675
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
+R ++L+S ++ +L +++ L ++ALL++ + IYA+IG+++F
Sbjct: 1676 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF----------- 1724
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
G++A D T N NF F
Sbjct: 1725 --GKIALNDTTEI------------------------------------NRNNNFQTFPQ 1746
Query: 943 AMLTVFQCVSLEGWTDVMY------------------WVNDAVGREWPWIYFVTLVILGS 1068
A+L +F+C + E W ++M + + G + YF++ +L +
Sbjct: 1747 AVLLLFRCATGEAWQEIMLACLPDKKCDPDSEPANSTEADHSCGSSFAVFYFISFYMLCA 1806
Query: 1069 FFVLNLVLGVLSGEF 1113
F ++NL + V+ F
Sbjct: 1807 FLIINLFVAVIMDNF 1821
Score = 67.8 bits (164), Expect = 3e-09
Identities = 52/242 (21%), Positives = 96/242 (39%), Gaps = 29/242 (11%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HYGQS + N+ F LF++EM+LK+ + Y +N FD +V+ SI++
Sbjct: 1581 QHYGQSCMFKEAMNILNMLFTGLFTVEMVLKLIAFKPKHYFCDAWNTFDALIVVGSIVDI 1640
Query: 1657 VLVYFDLMK--------------PLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXX 1794
+ + + + ++ R R++R+ K+
Sbjct: 1641 AITEVNPAENTQCSSSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQ 1700
Query: 1795 XXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDW 1974
GMQVFG + + NF TF QA+L +F+ TGE W
Sbjct: 1701 ALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAW 1760
Query: 1975 NTVMY---------------HGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+M + E+ G+ + Y+I ++ ++++N+F+A+ +
Sbjct: 1761 QEIMLACLPDKKCDPDSEPANSTEADHSCGSSFAV--FYFISFYMLCAFLIINLFVAVIM 1818
Query: 2110 DN 2115
DN
Sbjct: 1819 DN 1820
Score = 63.9 bits (154), Expect = 4e-08
Identities = 75/357 (21%), Positives = 133/357 (37%), Gaps = 96/357 (26%)
Frame = +1
Query: 3463 IFTGVFAFEAVLKIVA----LNPKNYISDRWNVFDLLVVVGSF----------------- 3579
+F +F EA LK++A +P Y+ + WN+ D ++VV
Sbjct: 357 LFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLPSKPDRMHVHHETLPKL 416
Query: 3580 -IDITYGKLNP---------------------GGTNL------ISINFFRLFRVMRLVKL 3675
T G+ GG ++ + R FRV+R ++L
Sbjct: 417 SFQSTQGRERTFICQRADRLFSAILEQATKADGGNSIGGKGAGFDVKALRAFRVLRPLRL 476
Query: 3676 LSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV------------- 3813
+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F GK+
Sbjct: 477 VSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYHVQGGLID 536
Query: 3814 --ALDDSTSI------------------------HRNNNFHSFPAAILVLFRSATGEAWQ 3915
A DD + H NF +F A+L +F+ T E W
Sbjct: 537 TPAEDDPSPCAPQSAHGRQCQNGTECKAGWEGPKHGITNFDNFAFAMLTVFQCITMEGWT 596
Query: 3916 DIMLSCSDREDVRCD-------PMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVIN 4074
D++ D + + L G ++ + YF++ ++ SF V+N
Sbjct: 597 DVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVNDAIGRDWPWIYFVTLIIIGSFFVLN 656
Query: 4075 LFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
L + V+ F G + +R + + D KG +LD +T I P
Sbjct: 657 LVLGVLSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 707
Score = 55.1 bits (131), Expect = 2e-05
Identities = 24/47 (51%), Positives = 33/47 (70%)
Frame = +1
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTS 2643
+Y F +FTVE LKVI +GL+FH ++ RN +NLLD ++V V L S
Sbjct: 355 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLPS 401
Score = 42.0 bits (97), Expect = 0.17
Identities = 47/234 (20%), Positives = 89/234 (37%), Gaps = 38/234 (16%)
Frame = +1
Query: 1522 ANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPL 1689
A+ F +F++E++LKM + G ++ + FN D VV S++ F + +
Sbjct: 1278 ADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINV-- 1335
Query: 1690 GVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFG 1869
V +LR R+LR + G+Q+F
Sbjct: 1336 -VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFK 1394
Query: 1870 GKF----------------------NFNPQQP--KPRA------NFDTFVQALLTVFQIL 1959
GK + QP +PR+ +FD + A++ +F +
Sbjct: 1395 GKLYSCTDSSKQTEAECRGYYITYKDGEVSQPMIQPRSWENSKFDFDNVLTAMMALFTVS 1454
Query: 1960 TGEDWNTVMYHGIES----FGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
T E W ++Y I+S G + V + I++I+ I + ++N+F+ +
Sbjct: 1455 TFEGWPELLYRSIDSHMEDVGPIYNHRVEISIFFIIYIIIIAFFMMNIFVGFVI 1508
>gi|508187|emb|CAA84349.1| voltage-dependent L-type Ca channel alpha 1
subunit [Homo sapiens]
Length = 2158
Score = 1016 bits (2628), Expect = 0.0
Identities = 512/850 (60%), Positives = 641/850 (75%), Gaps = 32/850 (3%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPR +SE+ P+P+AS+ FI S N FR+ C+ +VN + FTN +LF IL+SS L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 2446 AAEDPLQANSTRNMILNYFD--------------------YFFTSVFTVEITLKVIVFGL 2565
AAEDP+Q S RN IL YFD Y FTS+FT+EI LK+ +G
Sbjct: 918 AAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVFTSIFTLEIILKMTAYGA 977
Query: 2566 VFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKH 2745
HKGSFCRN FN+LD+LVV+VSL SF +++ A++ AINRAKGLKH
Sbjct: 978 FLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKH 1037
Query: 2746 VVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYE 2925
VVQCV VA++TIGNI++VT +LQFMFA IGVQLFKG + C+D SK TEAEC+G YI Y+
Sbjct: 1038 VVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYK 1097
Query: 2926 DGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHN 3105
DG+ P+ + R W N+ F+FDNV AM++LF VSTFEGWP+LLY +IDS+ EDKGPI+N
Sbjct: 1098 DGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYN 1157
Query: 3106 SRQAVALXXXXXXXXXXXXXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAK 3285
R +++ GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+
Sbjct: 1158 YRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKAR 1217
Query: 3286 PHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLI 3465
P RRYIP+N+ QY+VW+ V S FEY++F++I++NT+ LA +HY S F+ +++ N++
Sbjct: 1218 PLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNML 1277
Query: 3466 FTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGG---------- 3615
FTG+F E +LK++A PK+Y D WN FD L+VVGS +DI ++NP
Sbjct: 1278 FTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNA 1337
Query: 3616 --TNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVI 3789
+ ISI FFRLFRVMRLVKLLSRGEGIRTLLWTF+KSFQALPYVALLIV+LFFIYAVI
Sbjct: 1338 EENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVI 1397
Query: 3790 GMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMS 3969
GMQ FGK+AL+D+T I+RNNNF +FP A+L+LFR ATGEAWQDIML+C + +C P S
Sbjct: 1398 GMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGK--KCAPES 1455
Query: 3970 DDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHL 4149
+ + E+ CG++FA YFISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL
Sbjct: 1456 EPSNSTE-GETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHL 1514
Query: 4150 EEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDG 4329
+EF R+W+EYDP+AKGRIKHLDVVTLLR+I PPLGFGKLCPHR+ACKRLVSMNMPLNSDG
Sbjct: 1515 DEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDG 1574
Query: 4330 TVCFNATLFALVRTNLKIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDV 4509
TV FNATLFALVRT L+I TEGN+++ANE+LR+ IK+IWKRT LLD+VVPPAG +D+V
Sbjct: 1575 TVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAG-DDEV 1633
Query: 4510 TVGKFYATFLIQDYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISG 4689
TVGKFYATFLIQ+YFR+FKKRKE G P+Q A++LQAGLRTLH+IGPE++RAISG
Sbjct: 1634 TVGKFYATFLIQEYFRKFKKRKEQGLVG-KPSQR-NALSLQAGLRTLHDIGPEIRRAISG 1691
Query: 4690 NLETDFNFDE 4719
+L + D+
Sbjct: 1692 DLTAEEELDK 1701
Score = 722 bits (1863), Expect = 0.0
Identities = 383/698 (54%), Positives = 459/698 (64%), Gaps = 28/698 (4%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXX-XXXNNPIRKLCISIVEWKPFEFLILFMICANCIA 312
+KR KP +Q + NPIR+ CISIVEWKPFE +IL I ANC+A
Sbjct: 81 RKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVA 140
Query: 313 LAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDF 492
LAIY P+P DS+ N+ LE +EY+F+++FT+E LK++A G +FHP+AYLRN WN+LDF
Sbjct: 141 LAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDF 200
Query: 493 IIVVIGLVSTILSKMSIQ-----------GFDVKALRAFRVLRPLRLVSGVPSLQVVLNA 639
IIVV+GL S IL + + GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+
Sbjct: 201 IIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNS 260
Query: 640 ILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPA--TGQLAQKDPTPCGTDT 813
I++AM+PLLHIALLVLFVI+IYAIIGLELF GK+H TC + A+ DP+PC +T
Sbjct: 261 IIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALET 320
Query: 814 EGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDV 993
G +CQ + ++ G W GP +GITNFDNF AMLTVFQC+++EGWTDV
Sbjct: 321 -GHGRQCQ-NGTVCKPG----------WDGPKHGITNFDNFAFAMLTVFQCITMEGWTDV 368
Query: 994 MYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQ 1173
+YWVNDAVGR+WPWIYFVTL+I+GSFFVLNLVLGVLSGEFSKEREKA+ARG FQK REKQ
Sbjct: 369 LYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 428
Query: 1174 QLEEDLKGYLDWITQAEDIEPVNEDEQEDE--------PVAQTXXXXXXXXXXXXXXXXX 1329
QLEEDLKGYLDWITQAEDI+P NEDE DE P ++T
Sbjct: 429 QLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGEN 488
Query: 1330 XPSKWAARMKRLE------KLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQ 1491
++ A R+ + + + N VKS FYW SEHY Q
Sbjct: 489 CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQ 548
Query: 1492 SEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYF 1671
WL Q AN + LF+ EMLLKMYSLG Y S FNRFDCFVV ILE +LV
Sbjct: 549 PNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+M PLG+SVLR RLLRIFK+T+YW
Sbjct: 609 KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668
Query: 1852 GMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGV 2031
GMQ+FGGKFNF+ Q + R+ FD F Q+LLTVFQILTGEDWN+VMY GI ++GG G+
Sbjct: 669 GMQLFGGKFNFDEMQTR-RSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGM 727
Query: 2032 IVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNA 2145
+VCIY+I+LFICGNYILLNVFLAIAVDNLADA+SLT+A
Sbjct: 728 LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSA 765
Score = 120 bits (301), Expect = 4e-25
Identities = 103/362 (28%), Positives = 164/362 (44%), Gaps = 30/362 (8%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V NN R C IV F LILF I + I+L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 316 AIYQPYPAQDSDYKN----------TLLETIE----------YVFIVVFTIECVLKIVAM 435
A P Q + ++N T + TIE YVF +FT+E +LK+ A
Sbjct: 918 AAEDP--VQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVFTSIFTLEIILKMTAY 975
Query: 436 GFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVP 615
G H ++ RN +NILD ++V + L+S + +I VK LR RVLRPLR ++
Sbjct: 976 GAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINV--VKILRVLRVLRPLRAINRAK 1033
Query: 616 SLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ-KDP 792
L+ V+ + A+ + +I ++ + ++A IG++LF GKL+ TC D + A+ K
Sbjct: 1034 GLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLY-TCSDSSKQTEAECKGN 1092
Query: 793 TPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVS 972
D E QP WE N +FDN AM+ +F +
Sbjct: 1093 YITYKDGEVDHPIIQPRS--------WE-----------NSKFDFDNVLAAMMALFTVST 1133
Query: 973 LEGWTDVMYWVNDAVGREWPWIY---------FVTLVILGSFFVLNLVLGVLSGEFSKER 1125
EGW +++Y D+ + IY F+ +I+ +FF++N+ +G + F ++
Sbjct: 1134 FEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQG 1193
Query: 1126 EK 1131
E+
Sbjct: 1194 EQ 1195
Score = 95.9 bits (237), Expect = 1e-17
Identities = 64/259 (24%), Positives = 124/259 (47%), Gaps = 5/259 (1%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S F +++ ++ +NT+++A +HY + D N +F E +LK+ +L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD VV G ++ + + + I+ R R++R+ K+ +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL--VETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + + S +++ + LL+ L I++++GMQ F GK D+ + R + F +FP ++
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT--RRSTFDNFPQSL 696
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNF----AYPYFISF 4044
L +F+ TGE W +M D G G +F YFI
Sbjct: 697 LTVFQILTGEDWNSVMY--------------DGIMAYG------GPSFPGMLVCIYFIIL 736
Query: 4045 FMLCSFLVINLFVAVIMDN 4101
F+ +++++N+F+A+ +DN
Sbjct: 737 FICGNYILLNVFLAIAVDN 755
Score = 90.9 bits (224), Expect = 3e-16
Identities = 88/353 (24%), Positives = 148/353 (40%), Gaps = 54/353 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE +I L I N V+LA +P S L+ +F +F EA LK++A
Sbjct: 124 KPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGL 183
Query: 3511 -LNPKNYISDRWNVFD-LLVVVGSFIDITYGKLNPGGTNLIS-------INFFRLFRVMR 3663
+P Y+ + WN+ D ++VVVG F I G N + + R FRV+R
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLR 243
Query: 3664 LVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV--------- 3813
++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F GK+
Sbjct: 244 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEG 303
Query: 3814 -----ALDDSTSI------------------------HRNNNFHSFPAAILVLFRSATGE 3906
A DD + H NF +F A+L +F+ T E
Sbjct: 304 IADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITME 363
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVA 4086
W D++ +D G ++ + YF++ ++ SF V+NL +
Sbjct: 364 GWTDVLYWVND---------------------AVGRDWPWIYFVTLIIIGSFFVLNLVLG 402
Query: 4087 VIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
V+ F G + +R + + D KG +LD +T I P
Sbjct: 403 VLSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 449
Score = 89.0 bits (219), Expect = 1e-15
Identities = 77/282 (27%), Positives = 122/282 (42%), Gaps = 29/282 (10%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR--NMILNYF 2502
+L L+ N R C +V F +L I + LA P + + N L
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL----RTDAMS 2670
+Y F +FTVE LKVI +GL+FH ++ RN +NLLD ++V V L S +L + D +
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 2671 XXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
A ++ L+ V+ +I A+ + +I L+ + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 2824 AIIGVQLFKGTFF-LCNDLSKMTE-------AECRGEYIH---YEDGDPTKPVSKKRVW- 2967
AIIG++LF G C + + + + C E H ++G KP W
Sbjct: 283 AIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKP-----GWD 337
Query: 2968 --SNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEED 3087
+ NFDN AM+++F T EGW +LY D+ D
Sbjct: 338 GPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRD 379
Score = 82.8 bits (203), Expect = 9e-14
Identities = 73/315 (23%), Positives = 130/315 (41%), Gaps = 33/315 (10%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+L+ +I N I LA+ Q Y Q +K + + +F +FT+E +LK++A F
Sbjct: 1241 FEYLMFVLILLNTICLAM-QHY-GQSCLFK-IAMNILNMLFTGLFTVEMILKLIA----F 1293
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMSI---------------QGFDVKALRAFRV 582
P Y +AWN D +IVV +V +++++ + R FRV
Sbjct: 1294 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRV 1353
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
+R ++L+S ++ +L +++ L ++ALL++ + IYA+IG+++F
Sbjct: 1354 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF----------- 1402
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
G++A D T N NF F
Sbjct: 1403 --GKIALNDTTEI------------------------------------NRNNNFQTFPQ 1424
Query: 943 AMLTVFQCVSLEGWTDVMYWV------------------NDAVGREWPWIYFVTLVILGS 1068
A+L +F+C + E W D+M G + YF++ +L +
Sbjct: 1425 AVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCA 1484
Query: 1069 FFVLNLVLGVLSGEF 1113
F ++NL + V+ F
Sbjct: 1485 FLIINLFVAVIMDNF 1499
Score = 69.7 bits (169), Expect = 8e-10
Identities = 55/240 (22%), Positives = 96/240 (39%), Gaps = 27/240 (11%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HYGQS + N+ F LF++EM+LK+ + Y +N FD +V+ SI++
Sbjct: 1259 QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDI 1318
Query: 1657 VLVYFDLMKP--------------LGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXX 1794
+ + + + ++ R R++R+ K+
Sbjct: 1319 AITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQ 1378
Query: 1795 XXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDW 1974
GMQVFG + + NF TF QA+L +F+ TGE W
Sbjct: 1379 ALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAW 1438
Query: 1975 NTVMYHGI-------ESFGGVGTLGVIVC------IYYIVLFICGNYILLNVFLAIAVDN 2115
+M + ES T G C Y+I ++ ++++N+F+A+ +DN
Sbjct: 1439 QDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDN 1498
Score = 42.0 bits (97), Expect = 0.17
Identities = 46/234 (19%), Positives = 86/234 (36%), Gaps = 38/234 (16%)
Frame = +1
Query: 1522 ANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPL 1689
A+ F +F++E++LKM + G ++ + FN D VV S++ F + +
Sbjct: 956 ADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINV-- 1013
Query: 1690 GVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFG 1869
V +LR R+LR + G+Q+F
Sbjct: 1014 -VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFK 1072
Query: 1870 GKFNFNPQQPK------------------------PRA------NFDTFVQALLTVFQIL 1959
GK K PR+ +FD + A++ +F +
Sbjct: 1073 GKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVS 1132
Query: 1960 TGEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
T E W ++Y I+S G + V + I++I+ I + ++N+F+ +
Sbjct: 1133 TFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1186
>gi|508199|emb|CAA84343.1| voltage-dependent L-type Ca channel alpha 1
subunit [Homo sapiens]
Length = 2146
Score = 1016 bits (2627), Expect = 0.0
Identities = 510/838 (60%), Positives = 639/838 (75%), Gaps = 20/838 (2%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPR +SE+ P+P+AS+ FI S N FR+ C+ +VN + FTN +LF IL+SS L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP+Q S RN IL YFD FT++FT+EI LK+ +G HKGSFCRN FN+LD+LVV
Sbjct: 918 AAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVV 977
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
+VSL SF +++ A++ AINRAKGLKHVVQCV VA++TIGNI++VT
Sbjct: 978 SVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 1037
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG + C+D SK TEAEC+G YI Y+DG+ P+ + R W N+ F+
Sbjct: 1038 LLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFD 1097
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP+LLY +IDS+ EDKGPI+N R +++
Sbjct: 1098 FDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFM 1157
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N+ QY+VW+ V
Sbjct: 1158 MNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVN 1217
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S F+ +++ N++FTG+F E +LK++A PK+
Sbjct: 1218 STYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKH 1277
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGGTNL-ISINFFRLFRVMRLVKLLSRGEGIRT 3702
Y D WN FD L+VVGS +DI ++N N ISI FFRLFRVMRLVKLLSRGEGIRT
Sbjct: 1278 YFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEGIRT 1337
Query: 3703 LLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILV 3882
LLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL+D+T I+RNNNF +FP A+L+
Sbjct: 1338 LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLL 1397
Query: 3883 LFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSF 4062
LFR ATGEAWQDIML+C + +C P S+ + E+ CG++FA YFISF+MLC+F
Sbjct: 1398 LFRCATGEAWQDIMLACMPGK--KCAPESEPSNSTE-GETPCGSSFAVFYFISFYMLCAF 1454
Query: 4063 LVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKIS 4242
L+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+W+EYDP+AKGRIKHLDVVTLLR+I
Sbjct: 1455 LIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQ 1514
Query: 4243 PPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTE---------- 4392
PPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFALVRT L+I TE
Sbjct: 1515 PPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEEGPSPSEAHQ 1574
Query: 4393 ---------GNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQ 4545
GN+++ANE+LR+ IK+IWKRT LLD+VVPPAG +D+VTVGKFYATFLIQ
Sbjct: 1575 GAEDPFRPAGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQ 1633
Query: 4546 DYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDE 4719
+YFR+FKKRKE G P+Q A++LQAGLRTLH+IGPE++RAISG+L + D+
Sbjct: 1634 EYFRKFKKRKEQGLVG-KPSQR-NALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDK 1689
Score = 722 bits (1863), Expect = 0.0
Identities = 383/698 (54%), Positives = 459/698 (64%), Gaps = 28/698 (4%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXX-XXXNNPIRKLCISIVEWKPFEFLILFMICANCIA 312
+KR KP +Q + NPIR+ CISIVEWKPFE +IL I ANC+A
Sbjct: 81 RKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVA 140
Query: 313 LAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDF 492
LAIY P+P DS+ N+ LE +EY+F+++FT+E LK++A G +FHP+AYLRN WN+LDF
Sbjct: 141 LAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDF 200
Query: 493 IIVVIGLVSTILSKMSIQ-----------GFDVKALRAFRVLRPLRLVSGVPSLQVVLNA 639
IIVV+GL S IL + + GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+
Sbjct: 201 IIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNS 260
Query: 640 ILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPA--TGQLAQKDPTPCGTDT 813
I++AM+PLLHIALLVLFVI+IYAIIGLELF GK+H TC + A+ DP+PC +T
Sbjct: 261 IIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALET 320
Query: 814 EGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDV 993
G +CQ + ++ G W GP +GITNFDNF AMLTVFQC+++EGWTDV
Sbjct: 321 -GHGRQCQ-NGTVCKPG----------WDGPKHGITNFDNFAFAMLTVFQCITMEGWTDV 368
Query: 994 MYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQ 1173
+YWVNDAVGR+WPWIYFVTL+I+GSFFVLNLVLGVLSGEFSKEREKA+ARG FQK REKQ
Sbjct: 369 LYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 428
Query: 1174 QLEEDLKGYLDWITQAEDIEPVNEDEQEDE--------PVAQTXXXXXXXXXXXXXXXXX 1329
QLEEDLKGYLDWITQAEDI+P NEDE DE P ++T
Sbjct: 429 QLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGEN 488
Query: 1330 XPSKWAARMKRLE------KLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQ 1491
++ A R+ + + + N VKS FYW SEHY Q
Sbjct: 489 CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQ 548
Query: 1492 SEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYF 1671
WL Q AN + LF+ EMLLKMYSLG Y S FNRFDCFVV ILE +LV
Sbjct: 549 PNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+M PLG+SVLR RLLRIFK+T+YW
Sbjct: 609 KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668
Query: 1852 GMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGV 2031
GMQ+FGGKFNF+ Q + R+ FD F Q+LLTVFQILTGEDWN+VMY GI ++GG G+
Sbjct: 669 GMQLFGGKFNFDEMQTR-RSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGM 727
Query: 2032 IVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNA 2145
+VCIY+I+LFICGNYILLNVFLAIAVDNLADA+SLT+A
Sbjct: 728 LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSA 765
Score = 127 bits (320), Expect = 2e-27
Identities = 100/342 (29%), Positives = 160/342 (46%), Gaps = 10/342 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V NN R C IV F LILF I + I+L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P Q + ++N +L + VF +FTIE LK+ A G H ++ RN +NILD +
Sbjct: 918 AAEDP--VQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLL 975
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S + +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 976 VVSVSLISFGIQSSAINV--VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIV 1033
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ-KDPTPCGTDTEGSAFKCQPSDSL 852
++ + ++A IG++LF GKL+ TC D + A+ K D E QP
Sbjct: 1034 IVTTLLQFMFACIGVQLFKGKLY-TCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRS-- 1090
Query: 853 TNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWP 1032
WE N +FDN AM+ +F + EGW +++Y D+ +
Sbjct: 1091 ------WE-----------NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKG 1133
Query: 1033 WIY---------FVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
IY F+ +I+ +FF++N+ +G + F ++ E+
Sbjct: 1134 PIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1175
Score = 95.9 bits (237), Expect = 1e-17
Identities = 64/259 (24%), Positives = 124/259 (47%), Gaps = 5/259 (1%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S F +++ ++ +NT+++A +HY + D N +F E +LK+ +L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD VV G ++ + + + I+ R R++R+ K+ +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL--VETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + + S +++ + LL+ L I++++GMQ F GK D+ + R + F +FP ++
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT--RRSTFDNFPQSL 696
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNF----AYPYFISF 4044
L +F+ TGE W +M D G G +F YFI
Sbjct: 697 LTVFQILTGEDWNSVMY--------------DGIMAYG------GPSFPGMLVCIYFIIL 736
Query: 4045 FMLCSFLVINLFVAVIMDN 4101
F+ +++++N+F+A+ +DN
Sbjct: 737 FICGNYILLNVFLAIAVDN 755
Score = 90.9 bits (224), Expect = 3e-16
Identities = 88/353 (24%), Positives = 148/353 (40%), Gaps = 54/353 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE +I L I N V+LA +P S L+ +F +F EA LK++A
Sbjct: 124 KPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGL 183
Query: 3511 -LNPKNYISDRWNVFD-LLVVVGSFIDITYGKLNPGGTNLIS-------INFFRLFRVMR 3663
+P Y+ + WN+ D ++VVVG F I G N + + R FRV+R
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLR 243
Query: 3664 LVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV--------- 3813
++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F GK+
Sbjct: 244 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEG 303
Query: 3814 -----ALDDSTSI------------------------HRNNNFHSFPAAILVLFRSATGE 3906
A DD + H NF +F A+L +F+ T E
Sbjct: 304 IADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITME 363
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVA 4086
W D++ +D G ++ + YF++ ++ SF V+NL +
Sbjct: 364 GWTDVLYWVND---------------------AVGRDWPWIYFVTLIIIGSFFVLNLVLG 402
Query: 4087 VIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
V+ F G + +R + + D KG +LD +T I P
Sbjct: 403 VLSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 449
Score = 89.0 bits (219), Expect = 1e-15
Identities = 77/282 (27%), Positives = 122/282 (42%), Gaps = 29/282 (10%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR--NMILNYF 2502
+L L+ N R C +V F +L I + LA P + + N L
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL----RTDAMS 2670
+Y F +FTVE LKVI +GL+FH ++ RN +NLLD ++V V L S +L + D +
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 2671 XXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
A ++ L+ V+ +I A+ + +I L+ + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 2824 AIIGVQLFKGTFF-LCNDLSKMTE-------AECRGEYIH---YEDGDPTKPVSKKRVW- 2967
AIIG++LF G C + + + + C E H ++G KP W
Sbjct: 283 AIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKP-----GWD 337
Query: 2968 --SNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEED 3087
+ NFDN AM+++F T EGW +LY D+ D
Sbjct: 338 GPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRD 379
Score = 87.0 bits (214), Expect = 5e-15
Identities = 73/304 (24%), Positives = 130/304 (42%), Gaps = 22/304 (7%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+L+ +I N I LA+ Q Y Q +K + + +F +FT+E +LK++A F
Sbjct: 1221 FEYLMFVLILLNTICLAM-QHY-GQSCLFK-IAMNILNMLFTGLFTVEMILKLIA----F 1273
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMSI----QGFDVKALRAFRVLRPLRLVSGVP 615
P Y +AWN D +IVV +V +++++ + R FRV+R ++L+S
Sbjct: 1274 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGE 1333
Query: 616 SLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPT 795
++ +L +++ L ++ALL++ + IYA+IG+++F G++A D T
Sbjct: 1334 GIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-------------GKIALNDTT 1380
Query: 796 PCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSL 975
N NF F A+L +F+C +
Sbjct: 1381 EI------------------------------------NRNNNFQTFPQAVLLLFRCATG 1404
Query: 976 EGWTDVMYWV------------------NDAVGREWPWIYFVTLVILGSFFVLNLVLGVL 1101
E W D+M G + YF++ +L +F ++NL + V+
Sbjct: 1405 EAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVI 1464
Query: 1102 SGEF 1113
F
Sbjct: 1465 MDNF 1468
Score = 74.3 bits (181), Expect = 3e-11
Identities = 55/229 (24%), Positives = 96/229 (41%), Gaps = 16/229 (6%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HYGQS + N+ F LF++EM+LK+ + Y +N FD +V+ SI++
Sbjct: 1239 QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDI 1298
Query: 1657 VLVYFDLMKP---LGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXX 1827
+ + + + ++ R R++R+ K+
Sbjct: 1299 AITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVM 1358
Query: 1828 XXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGI--- 1998
GMQVFG + + NF TF QA+L +F+ TGE W +M +
Sbjct: 1359 LFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGK 1418
Query: 1999 ----ESFGGVGTLGVIVC------IYYIVLFICGNYILLNVFLAIAVDN 2115
ES T G C Y+I ++ ++++N+F+A+ +DN
Sbjct: 1419 KCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDN 1467
Score = 41.2 bits (95), Expect = 0.29
Identities = 46/240 (19%), Positives = 87/240 (36%), Gaps = 38/240 (15%)
Frame = +1
Query: 1504 DHFQTMANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYF 1671
+H ++ F +F++E+ LKM + G ++ + FN D VV S++ F +
Sbjct: 930 NHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS 989
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+ V +LR R+LR +
Sbjct: 990 AINV---VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACI 1046
Query: 1852 GMQVFGGKFNFNPQQPK------------------------PRA------NFDTFVQALL 1941
G+Q+F GK K PR+ +FD + A++
Sbjct: 1047 GVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMM 1106
Query: 1942 TVFQILTGEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+F + T E W ++Y I+S G + V + I++I+ I + ++N+F+ +
Sbjct: 1107 ALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1166
>gi|14718596|gb|AAK72959.1| voltage-gated calcium channel pore forming
subunit CaV1.3alpha1 [Rattus norvegicus]
Length = 1643
Score = 1016 bits (2627), Expect = 0.0
Identities = 504/790 (63%), Positives = 614/790 (76%), Gaps = 1/790 (0%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPRR+SE+ + PIP+ S+ FILS TN RV C+ ++NH FTN +L I++SSA L
Sbjct: 855 RPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAAL 914
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP++++S RN IL YFDY FT++FTVEI LK+ FG HKG+FCRN FNLLD+LVV
Sbjct: 915 AAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVV 974
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
VSL SF +++ A+S AINRAKGLKHVVQCV VA++TIGNIM+VT
Sbjct: 975 GVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTT 1034
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG F+ C D +K ECRG +I Y+DGD PV ++R+W N+DFN
Sbjct: 1035 LLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFN 1094
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM+ LF VSTFEGWP LLY AIDSN E+ GP++N R +++
Sbjct: 1095 FDNVLSAMMVLFTVSTFEGWPALLYKAIDSNGENVGPVYNYRVEISIFFIIYIIIVAFFM 1154
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N QY+ W+ V
Sbjct: 1155 MNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVN 1214
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S+ F D +D+ N++FTGVF E VLK++A PK+
Sbjct: 1215 SSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKH 1274
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGG-TNLISINFFRLFRVMRLVKLLSRGEGIRT 3702
Y +D WN FD L+VVGS +DI ++N +N ISI FFRLFRVMRLVKLLSRGEGIRT
Sbjct: 1275 YFTDAWNTFDALIVVGSVVDIAITEVNNSEESNRISITFFRLFRVMRLVKLLSRGEGIRT 1334
Query: 3703 LLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILV 3882
LLWTF+KSFQALPYVALLI +LFFIYAVIGMQ FGKVA+ D+ I+RNNNF +FP A+L+
Sbjct: 1335 LLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLL 1394
Query: 3883 LFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSF 4062
LFR ATGEAWQ+IML+C + CDP SD Y+ G E CG+NFA YFISF+MLC+F
Sbjct: 1395 LFRCATGEAWQEIMLACLPGK--LCDPDSD-YNPG--EEYTCGSNFAIVYFISFYMLCAF 1449
Query: 4063 LVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKIS 4242
L+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+WSEYDP+AKGRIKHLDVVTLLR+I
Sbjct: 1450 LIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQ 1509
Query: 4243 PPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNIDEANEQL 4422
PPLGFGKLCPHR+ACKRLV+MNMPLNSDGTV FNATLFALVRT LKI TEGN+++ANE+L
Sbjct: 1510 PPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEEL 1569
Query: 4423 RSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEMEAKGVLP 4602
R+ IK+IWK+T LLD+VVPPAG +D+VTVGKFYATFLIQDYFR+FKKRKE G P
Sbjct: 1570 RAVIKKIWKKTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYP 1628
Query: 4603 AQTPQAMALQ 4632
A+ +ALQ
Sbjct: 1629 AKN-TTIALQ 1637
Score = 715 bits (1845), Expect = 0.0
Identities = 376/686 (54%), Positives = 450/686 (64%), Gaps = 44/686 (6%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
NNPIR+ CISIV+WKPF+ IL I ANC+ALAIY P+P DS+ N LE +EY F+++
Sbjct: 103 NNPIRRACISIVDWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLII 162
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQ----------- 546
FT+E LKI+A G + HP+AY+RN WN+LDF+IV++GL S IL +++ +
Sbjct: 163 FTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKS 222
Query: 547 -GFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLE 723
GFDVKALRAFRVLRPLRLVS VPSLQVVLN+I++AM+PLLHIALLVLFVI+IYAIIGLE
Sbjct: 223 GGFDVKALRAFRVLRPLRLVSSVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLE 282
Query: 724 LFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPG 903
LF GK+H TC + +A++DP PC G+ +C + + EC S W G
Sbjct: 283 LFIGKMHKTCFFADSDIVAEEDPAPCAFS--GNGRQCAANGT--------ECRSG--WVG 330
Query: 904 PNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLN 1083
PN GITNFDNF AMLTVFQC+++EGWTDV+YWVNDA+G EWPW+YFV+L+ILGSFFVLN
Sbjct: 331 PNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLN 390
Query: 1084 LVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDE 1263
LVLGVLSGEFSKEREKA+ARG FQK REKQQLEEDLKGYLDWITQAEDI+P NE+E +E
Sbjct: 391 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEE 450
Query: 1264 -------PVAQTXXXXXXXXXXXXXXXXXXPSKW-------AAR---------------- 1353
P ++T S W AA+
Sbjct: 451 GKRNTSMPTSETESVNTENVSGEGETQGCCGSLWCWWKRRGAAKTGPSGCRRWGQAISKS 510
Query: 1354 --MKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMAN 1527
+R + N VKS TFYW +SEHY Q +WL Q +AN
Sbjct: 511 KLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIAN 570
Query: 1528 LFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLR 1707
+ LF+ EML+KMYSLG Y S FNRFDCFVV I E +LV +LM PLGVSV R
Sbjct: 571 KVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELELMSPLGVSVFR 630
Query: 1708 SARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFN 1887
RLLRIFKVT++WT GMQ+FGGKFNF+
Sbjct: 631 CVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFD 690
Query: 1888 PQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFIC 2067
Q K R+ FD F QALLTVFQILTGEDWN VMY GI ++GG + G+IVCIY+I+LFIC
Sbjct: 691 ETQTK-RSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFIC 749
Query: 2068 GNYILLNVFLAIAVDNLADADSLTNA 2145
GNYILLNVFLAIAVDNLADA+SL A
Sbjct: 750 GNYILLNVFLAIAVDNLADAESLNTA 775
Score = 128 bits (322), Expect = 1e-27
Identities = 92/312 (29%), Positives = 152/312 (48%), Gaps = 9/312 (2%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR C ++ F LIL I + ALA P + ++NT+L +Y F +F
Sbjct: 884 NPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPI--RSHSFRNTILGYFDYAFTAIF 941
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
T+E +LK+ G H A+ RN +N+LD ++V + LVS + +I VK LR RV
Sbjct: 942 TVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAIS--VVKILRVLRV 999
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLR ++ L+ V+ + A+ + +I ++ + ++A IG++LF GK + C D
Sbjct: 1000 LRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFY-RCTDE 1058
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
A+ +P C F + + VR N+ + NFDN
Sbjct: 1059 -----AKSNPEEC-----RGLFILYKDGDVDSPVVRERIWQNSDF--------NFDNVLS 1100
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDAVG---------REWPWIYFVTLVILGSFFVLNLVLG 1095
AM+ +F + EGW ++Y D+ G R I+F+ +I+ +FF++N+ +G
Sbjct: 1101 AMMVLFTVSTFEGWPALLYKAIDSNGENVGPVYNYRVEISIFFIIYIIIVAFFMMNIFVG 1160
Query: 1096 VLSGEFSKEREK 1131
+ F ++ EK
Sbjct: 1161 FVIVTFQEQGEK 1172
Score = 102 bits (255), Expect = 8e-20
Identities = 70/276 (25%), Positives = 134/276 (48%), Gaps = 1/276 (0%)
Frame = +1
Query: 3277 KAKPHRRYIPRNRL-QYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDV 3453
K+K RR+ NR + R V S F +++ +++ +NT++++ +HY D+
Sbjct: 509 KSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDI 568
Query: 3454 FNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISI 3633
N + +F E ++K+ +L + Y +N FD VV G + +L + + +
Sbjct: 569 ANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEL--MSPLGV 626
Query: 3634 NFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKV 3813
+ FR R++R+ K+ + L+ + + S +++ + LL+ L I++++GMQ FG
Sbjct: 627 SVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGK 686
Query: 3814 ALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGL 3993
D T R+ F +FP A+L +F+ TGE W +M GG
Sbjct: 687 FNFDETQTKRST-FDNFPQALLTVFQILTGEDWNAVMYD-------------GIMAYGGP 732
Query: 3994 NESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDN 4101
+ S YFI F+ +++++N+F+A+ +DN
Sbjct: 733 SSS---GMIVCIYFIILFICGNYILLNVFLAIAVDN 765
Score = 97.4 bits (241), Expect = 3e-18
Identities = 76/317 (23%), Positives = 137/317 (42%), Gaps = 20/317 (6%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP + +V PFE+++ +I N + LA+ Q Y + S N ++ + VF VF
Sbjct: 1203 NPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAM-QHY--EQSKMFNDAMDILNMVFTGVF 1259
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMS----IQGFDVKALR 570
T+E VLK++A F P Y +AWN D +IVV +V +++++ + R
Sbjct: 1260 TVEMVLKVIA----FKPKHYFTDAWNTFDALIVVGSVVDIAITEVNNSEESNRISITFFR 1315
Query: 571 AFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHST 750
FRV+R ++L+S ++ +L +++ L ++ALL+ + IYA+IG+++F
Sbjct: 1316 LFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMF------- 1368
Query: 751 CIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFD 930
G++A +D N NF
Sbjct: 1369 ------GKVAMRDNNQI------------------------------------NRNNNFQ 1386
Query: 931 NFGLAMLTVFQCVSLEGWTDVMY----------------WVNDAVGREWPWIYFVTLVIL 1062
F A+L +F+C + E W ++M G + +YF++ +L
Sbjct: 1387 TFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPDSDYNPGEEYTCGSNFAIVYFISFYML 1446
Query: 1063 GSFFVLNLVLGVLSGEF 1113
+F ++NL + V+ F
Sbjct: 1447 CAFLIINLFVAVIMDNF 1463
Score = 92.8 bits (229), Expect = 8e-17
Identities = 146/706 (20%), Positives = 256/706 (35%), Gaps = 80/706 (11%)
Frame = +1
Query: 232 RKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIE 411
R+ C + V+ F +L++ ++ N + ++ D+ + + V + +FT E
Sbjct: 524 RRRCRAAVKSVTFYWLVIVLVFLNTLTISSEH---YNQPDWLTQIQDIANKVLLALFTCE 580
Query: 412 CVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG-FDVKALRAFRVLR 588
++K+ ++G AY + +N D +V G+ TIL ++ + V R R+LR
Sbjct: 581 MLVKMYSLGLQ----AYFVSLFNRFDCFVVCGGITETILVELELMSPLGVSVFRCVRLLR 636
Query: 589 PLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPAT 768
++ SL ++ ++L +M + + LL+ I+I++++
Sbjct: 637 IFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLL------------------ 678
Query: 769 GQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAM 948
G G F + + + FDNF A+
Sbjct: 679 -----------GMQLFGGKFNFDETQTKRS---------------------TFDNFPQAL 706
Query: 949 LTVFQCVSLEGWTDVMYWVNDAVGREWP-----WIYFVTLVILGSFFVLNLVLGVLSGEF 1113
LTVFQ ++ E W VMY A G IYF+ L I G++ +LN+ L +
Sbjct: 707 LTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNL 766
Query: 1114 S---------------KEREK-ARARGLFQKFREKQQLEE----DLKGYL-DWITQAEDI 1230
+ KER+K AR L K K ++ + D K + D+ +AED
Sbjct: 767 ADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYQEEAEDK 826
Query: 1231 EPV----------NEDEQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNX 1380
+P E+E+EDEP P + L K N
Sbjct: 827 DPYPPCDVPVGEEEEEEEEDEPEV-PAGPRPRRISELNMKEKIAPIPEGSAFFILSKTN- 884
Query: 1381 XXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSE-----HYGQSEWLDHFQTMANLFFVIL 1545
L+ F +E H ++ L +F + F +
Sbjct: 885 PIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYF----DYAFTAI 940
Query: 1546 FSMEMLLKMYSLGF----TTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSA 1713
F++E+LLKM + G + + FN D VV S++ F + + V +LR
Sbjct: 941 FTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISV---VKILRVL 997
Query: 1714 RLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF----- 1878
R+LR + G+Q+F GKF
Sbjct: 998 RVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTD 1057
Query: 1879 --NFNPQQ---------------PKPRA--------NFDTFVQALLTVFQILTGEDWNTV 1983
NP++ P R NFD + A++ +F + T E W +
Sbjct: 1058 EAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMVLFTVSTFEGWPAL 1117
Query: 1984 MYHGI----ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+Y I E+ G V V + I++I+ I + ++N+F+ +
Sbjct: 1118 LYKAIDSNGENVGPVYNYRVEISIFFIIYIIIVAFFMMNIFVGFVI 1163
Score = 90.1 bits (222), Expect = 6e-16
Identities = 79/275 (28%), Positives = 122/275 (43%), Gaps = 24/275 (8%)
Frame = +1
Query: 2323 ASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPL---QANSTRNMIL 2493
A +LF LS N R C +V+ F +L I + LA P +NST N L
Sbjct: 94 ARALFCLSLNNPIRRACISIVDWKPFDIFILLAIFANCVALAIYIPFPEDDSNST-NHNL 152
Query: 2494 NYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL-----RT 2658
+Y F +FTVE LK+I +GL+ H ++ RN +NLLD ++V V L S +L T
Sbjct: 153 EKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKET 212
Query: 2659 DAMSXXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFML 2811
+ + A ++ L+ V+ +I A+ + +I L+ +
Sbjct: 213 EGGNHSSGKSGGFDVKALRAFRVLRPLRLVSSVPSLQVVLNSIIKAMVPLLHIALLVLFV 272
Query: 2812 QFMFAIIGVQLF-----KGTFFLCNDL-SKMTEAECRGEYIHYEDGDPTKPVSKKRVWSN 2973
++AIIG++LF K FF +D+ ++ A C + V N
Sbjct: 273 IIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCAANGTECRSGWVGPN 332
Query: 2974 NDF-NFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
NFDN AM+++F T EGW +LY D+
Sbjct: 333 GGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDA 367
Score = 83.6 bits (205), Expect = 5e-14
Identities = 81/352 (23%), Positives = 140/352 (39%), Gaps = 53/352 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ F+ I L I N V+LA +P S L+ F +F E LKI+A
Sbjct: 117 KPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGL 176
Query: 3511 -LNPKNYISDRWNVFDLLVVVGSFIDITYGKL---------NPGGTNLISINFFRLFRVM 3660
L+P Y+ + WN+ D ++V+ + +L + G + + R FRV+
Sbjct: 177 LLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVL 236
Query: 3661 RLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF------------ 3804
R ++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F
Sbjct: 237 RPLRLVSSVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFAD 296
Query: 3805 -----------------GKVALDDSTSIHRN--------NNFHSFPAAILVLFRSATGEA 3909
G+ + T NF +F A+L +F+ T E
Sbjct: 297 SDIVAEEDPAPCAFSGNGRQCAANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEG 356
Query: 3910 WQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAV 4089
W D++ +D G + + YF+S +L SF V+NL + V
Sbjct: 357 WTDVLYWVND---------------------AIGWEWPWVYFVSLIILGSFFVLNLVLGV 395
Query: 4090 IMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
+ F G + +R + + D KG +LD +T I P
Sbjct: 396 LSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 441
Score = 73.9 bits (180), Expect = 4e-11
Identities = 50/230 (21%), Positives = 98/230 (41%), Gaps = 17/230 (7%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HY QS+ + + N+ F +F++EM+LK+ + Y T +N FD +V+ S+++
Sbjct: 1236 QHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKHYFTDAWNTFDALIVVGSVVDI 1295
Query: 1657 VLVYFDLMKP---LGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXX 1827
+ + + + ++ R R++R+ K+
Sbjct: 1296 AITEVNNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAM 1355
Query: 1828 XXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVM------- 1986
GMQ+FG + Q NF TF QA+L +F+ TGE W +M
Sbjct: 1356 LFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGK 1415
Query: 1987 -------YHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDN 2115
Y+ E + + +Y+I ++ ++++N+F+A+ +DN
Sbjct: 1416 LCDPDSDYNPGEEYTCGSNFAI---VYFISFYMLCAFLIINLFVAVIMDN 1462
>gi|508191|emb|CAA84351.1| voltage-dependent L-type Ca channel alpha 1
subunit [Homo sapiens]
Length = 2155
Score = 1015 bits (2625), Expect = 0.0
Identities = 512/847 (60%), Positives = 640/847 (75%), Gaps = 29/847 (3%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPR +SE+ P+P+AS+ FI S N FR+ C+ +VN + FTN +LF IL+SS L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP+Q S RN IL DY FTS+FT+EI LK+ +G HKGSFCRN FN+LD+LVV
Sbjct: 918 AAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVV 977
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
+VSL SF +++ A++ AINRAKGLKHVVQCV VA++TIGNI++VT
Sbjct: 978 SVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 1037
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG + C+D SK TEAEC+G YI Y+DG+ P+ + R W N+ F+
Sbjct: 1038 LLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFD 1097
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP+LLY +IDS+ EDKGPI+N R +++
Sbjct: 1098 FDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFM 1157
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N+ QY+VW+ V
Sbjct: 1158 MNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVN 1217
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S F+ +++ N++FTG+F E +LK++A PK
Sbjct: 1218 STYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKG 1277
Query: 3526 YISDRWNVFDLLVVVGSFIDI--------------TYGKL---------------NPGGT 3618
Y SD WNVFD L+V+GS ID+ T+ L N
Sbjct: 1278 YFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNNAEEN 1337
Query: 3619 NLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ 3798
+ ISI FFRLFRVMRLVKLLSRGEGIRTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ
Sbjct: 1338 SRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ 1397
Query: 3799 FFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDY 3978
FGK+AL+D+T I+RNNNF +FP A+L+LFR ATGEAWQDIML+C + +C P S+
Sbjct: 1398 VFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGK--KCAPESEPS 1455
Query: 3979 HKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEF 4158
+ E+ CG++FA YFISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF
Sbjct: 1456 NSTE-GETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEF 1514
Query: 4159 VRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVC 4338
R+W+EYDP+AKGRIKHLDVVTLLR+I PPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV
Sbjct: 1515 KRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVM 1574
Query: 4339 FNATLFALVRTNLKIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVG 4518
FNATLFALVRT L+I TEGN+++ANE+LR+ IK+IWKRT LLD+VVPPAG +D+VTVG
Sbjct: 1575 FNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAG-DDEVTVG 1633
Query: 4519 KFYATFLIQDYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLE 4698
KFYATFLIQ+YFR+FKKRKE G P+Q A++LQAGLRTLH+IGPE++RAISG+L
Sbjct: 1634 KFYATFLIQEYFRKFKKRKEQGLVG-KPSQR-NALSLQAGLRTLHDIGPEIRRAISGDLT 1691
Query: 4699 TDFNFDE 4719
+ D+
Sbjct: 1692 AEEELDK 1698
Score = 722 bits (1863), Expect = 0.0
Identities = 383/698 (54%), Positives = 459/698 (64%), Gaps = 28/698 (4%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXX-XXXNNPIRKLCISIVEWKPFEFLILFMICANCIA 312
+KR KP +Q + NPIR+ CISIVEWKPFE +IL I ANC+A
Sbjct: 81 RKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVA 140
Query: 313 LAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDF 492
LAIY P+P DS+ N+ LE +EY+F+++FT+E LK++A G +FHP+AYLRN WN+LDF
Sbjct: 141 LAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDF 200
Query: 493 IIVVIGLVSTILSKMSIQ-----------GFDVKALRAFRVLRPLRLVSGVPSLQVVLNA 639
IIVV+GL S IL + + GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+
Sbjct: 201 IIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNS 260
Query: 640 ILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPA--TGQLAQKDPTPCGTDT 813
I++AM+PLLHIALLVLFVI+IYAIIGLELF GK+H TC + A+ DP+PC +T
Sbjct: 261 IIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALET 320
Query: 814 EGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDV 993
G +CQ + ++ G W GP +GITNFDNF AMLTVFQC+++EGWTDV
Sbjct: 321 -GHGRQCQ-NGTVCKPG----------WDGPKHGITNFDNFAFAMLTVFQCITMEGWTDV 368
Query: 994 MYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQ 1173
+YWVNDAVGR+WPWIYFVTL+I+GSFFVLNLVLGVLSGEFSKEREKA+ARG FQK REKQ
Sbjct: 369 LYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 428
Query: 1174 QLEEDLKGYLDWITQAEDIEPVNEDEQEDE--------PVAQTXXXXXXXXXXXXXXXXX 1329
QLEEDLKGYLDWITQAEDI+P NEDE DE P ++T
Sbjct: 429 QLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGEN 488
Query: 1330 XPSKWAARMKRLE------KLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQ 1491
++ A R+ + + + N VKS FYW SEHY Q
Sbjct: 489 CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQ 548
Query: 1492 SEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYF 1671
WL Q AN + LF+ EMLLKMYSLG Y S FNRFDCFVV ILE +LV
Sbjct: 549 PNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+M PLG+SVLR RLLRIFK+T+YW
Sbjct: 609 KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668
Query: 1852 GMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGV 2031
GMQ+FGGKFNF+ Q + R+ FD F Q+LLTVFQILTGEDWN+VMY GI ++GG G+
Sbjct: 669 GMQLFGGKFNFDEMQTR-RSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGM 727
Query: 2032 IVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNA 2145
+VCIY+I+LFICGNYILLNVFLAIAVDNLADA+SLT+A
Sbjct: 728 LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSA 765
Score = 131 bits (329), Expect = 2e-28
Identities = 100/342 (29%), Positives = 162/342 (47%), Gaps = 10/342 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V NN R C IV F LILF I + I+L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P Q + ++N +L +YVF +FT+E +LK+ A G H ++ RN +NILD +
Sbjct: 918 AAEDP--VQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLL 975
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S + +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 976 VVSVSLISFGIQSSAINV--VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIV 1033
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ-KDPTPCGTDTEGSAFKCQPSDSL 852
++ + ++A IG++LF GKL+ TC D + A+ K D E QP
Sbjct: 1034 IVTTLLQFMFACIGVQLFKGKLY-TCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRS-- 1090
Query: 853 TNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWP 1032
WE N +FDN AM+ +F + EGW +++Y D+ +
Sbjct: 1091 ------WE-----------NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKG 1133
Query: 1033 WIY---------FVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
IY F+ +I+ +FF++N+ +G + F ++ E+
Sbjct: 1134 PIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1175
Score = 95.9 bits (237), Expect = 1e-17
Identities = 64/259 (24%), Positives = 124/259 (47%), Gaps = 5/259 (1%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S F +++ ++ +NT+++A +HY + D N +F E +LK+ +L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD VV G ++ + + + I+ R R++R+ K+ +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL--VETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + + S +++ + LL+ L I++++GMQ F GK D+ + R + F +FP ++
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT--RRSTFDNFPQSL 696
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNF----AYPYFISF 4044
L +F+ TGE W +M D G G +F YFI
Sbjct: 697 LTVFQILTGEDWNSVMY--------------DGIMAYG------GPSFPGMLVCIYFIIL 736
Query: 4045 FMLCSFLVINLFVAVIMDN 4101
F+ +++++N+F+A+ +DN
Sbjct: 737 FICGNYILLNVFLAIAVDN 755
Score = 90.9 bits (224), Expect = 3e-16
Identities = 88/353 (24%), Positives = 148/353 (40%), Gaps = 54/353 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE +I L I N V+LA +P S L+ +F +F EA LK++A
Sbjct: 124 KPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGL 183
Query: 3511 -LNPKNYISDRWNVFD-LLVVVGSFIDITYGKLNPGGTNLIS-------INFFRLFRVMR 3663
+P Y+ + WN+ D ++VVVG F I G N + + R FRV+R
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLR 243
Query: 3664 LVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV--------- 3813
++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F GK+
Sbjct: 244 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEG 303
Query: 3814 -----ALDDSTSI------------------------HRNNNFHSFPAAILVLFRSATGE 3906
A DD + H NF +F A+L +F+ T E
Sbjct: 304 IADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITME 363
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVA 4086
W D++ +D G ++ + YF++ ++ SF V+NL +
Sbjct: 364 GWTDVLYWVND---------------------AVGRDWPWIYFVTLIIIGSFFVLNLVLG 402
Query: 4087 VIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
V+ F G + +R + + D KG +LD +T I P
Sbjct: 403 VLSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 449
Score = 89.0 bits (219), Expect = 1e-15
Identities = 77/282 (27%), Positives = 122/282 (42%), Gaps = 29/282 (10%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR--NMILNYF 2502
+L L+ N R C +V F +L I + LA P + + N L
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL----RTDAMS 2670
+Y F +FTVE LKVI +GL+FH ++ RN +NLLD ++V V L S +L + D +
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 2671 XXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
A ++ L+ V+ +I A+ + +I L+ + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 2824 AIIGVQLFKGTFF-LCNDLSKMTE-------AECRGEYIH---YEDGDPTKPVSKKRVW- 2967
AIIG++LF G C + + + + C E H ++G KP W
Sbjct: 283 AIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKP-----GWD 337
Query: 2968 --SNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEED 3087
+ NFDN AM+++F T EGW +LY D+ D
Sbjct: 338 GPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRD 379
Score = 84.0 bits (206), Expect = 4e-14
Identities = 75/332 (22%), Positives = 132/332 (39%), Gaps = 50/332 (15%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+L+ +I N I LA+ Q Y Q +K + + +F +FT+E +LK++A F
Sbjct: 1221 FEYLMFVLILLNTICLAM-QHY-GQSCLFK-IAMNILNMLFTGLFTVEMILKLIA----F 1273
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD------------------------ 555
P Y + WN+ DF+IV+ ++ ILS+ + D
Sbjct: 1274 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNN 1333
Query: 556 --------VKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAI 711
+ R FRV+R ++L+S ++ +L +++ L ++ALL++ + IYA+
Sbjct: 1334 AEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAV 1393
Query: 712 IGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNT 891
IG+++F G++A D T
Sbjct: 1394 IGMQVF-------------GKIALNDTTEI------------------------------ 1410
Query: 892 TWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWV------------------NDAV 1017
N NF F A+L +F+C + E W D+M
Sbjct: 1411 ------NRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPC 1464
Query: 1018 GREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
G + YF++ +L +F ++NL + V+ F
Sbjct: 1465 GSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1496
Score = 66.6 bits (161), Expect = 7e-09
Identities = 60/257 (23%), Positives = 100/257 (38%), Gaps = 44/257 (17%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HYGQS + N+ F LF++EM+LK+ + Y + +N FD +VI SI++
Sbjct: 1239 QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDV 1298
Query: 1657 VLVY-----------FDLMKPLG--------------------VSVLRSARLLRIFKVTK 1743
+L FD + +G ++ R R++R+ K+
Sbjct: 1299 ILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLS 1358
Query: 1744 YWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDT 1923
GMQVFG + + NF T
Sbjct: 1359 RGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQT 1418
Query: 1924 FVQALLTVFQILTGEDWNTVMYHGI-------ESFGGVGTLGVIVC------IYYIVLFI 2064
F QA+L +F+ TGE W +M + ES T G C Y+I ++
Sbjct: 1419 FPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYM 1478
Query: 2065 CGNYILLNVFLAIAVDN 2115
++++N+F+A+ +DN
Sbjct: 1479 LCAFLIINLFVAVIMDN 1495
Score = 43.1 bits (100), Expect = 0.077
Identities = 47/240 (19%), Positives = 88/240 (36%), Gaps = 38/240 (15%)
Frame = +1
Query: 1504 DHFQTMANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYF 1671
+H A+ F +F++E++LKM + G ++ + FN D VV S++ F +
Sbjct: 930 NHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS 989
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+ V +LR R+LR +
Sbjct: 990 AINV---VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACI 1046
Query: 1852 GMQVFGGKFNFNPQQPK------------------------PRA------NFDTFVQALL 1941
G+Q+F GK K PR+ +FD + A++
Sbjct: 1047 GVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMM 1106
Query: 1942 TVFQILTGEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+F + T E W ++Y I+S G + V + I++I+ I + ++N+F+ +
Sbjct: 1107 ALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1166
>gi|6165996|sp|Q02485|CCAS_RAT Voltage-dependent L-type calcium
channel alpha-1S subunit (Voltage-gated calcium channel
alpha subunit Cav1.1) (Calcium channel, L type, alpha-1
polypeptide, isoform 3, skeletal muscle) (ROB1)
gi|203218|gb|AAA40844.1| dihydropyridine-sesitive L-type calcium
channel alpha-1 subunit
Length = 1146
Score = 1015 bits (2624), Expect = 0.0
Identities = 536/941 (56%), Positives = 654/941 (68%), Gaps = 46/941 (4%)
Frame = +1
Query: 2260 SARPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSA 2439
S RPR ++E+ PIP+ASS FI S TN RV C+ +VN ++FTN +L IL+SSA
Sbjct: 42 SPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSA 101
Query: 2440 MLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDIL 2619
LAAEDP++A+S RN IL YFDY FT+VFTVEI LK+ +G HKGSFCRN FN+LD+L
Sbjct: 102 ALAAEDPIRADSMRNQILEYFDYVFTAVFTVEIVLKMTTYGAFLHKGSFCRNYFNILDLL 161
Query: 2620 VVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLV 2799
VVAVSL S L + A+S AINRAKGLKHVVQCV VA++TIGNI+LV
Sbjct: 162 VVAVSLISMGLESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVLV 221
Query: 2800 TFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNND 2979
T +LQFMFA IGVQLFKG F+ CNDLSKMTE ECRG Y Y+DGDPT+ + R W +ND
Sbjct: 222 TTLLQFMFACIGVQLFKGKFYSCNDLSKMTEEECRGYYYIYKDGDPTQIELRPRQWIHND 281
Query: 2980 FNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXX 3159
F+FDNV AM+SLF VSTFEGWPQLLY AIDSNEED GP++N+R +A+
Sbjct: 282 FHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNEEDTGPVYNNRVEMAIFFIIYIILIAF 341
Query: 3160 XXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWF 3339
GFVIVTFQ +GE EY+NCELDKNQR+C+++ALKA+P R YIP+N QY+VW+
Sbjct: 342 FMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQVWYV 401
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
VTS FEY++F +I++NT+ L +HY S D+ N+ FT +F E +LK++A P
Sbjct: 402 VTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLIAFKP 461
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITY--------------------GKLNPGGTNLISINF 3639
+ Y D WNVFD L+V+GS ID+ G ++P + IS F
Sbjct: 462 RGYFGDPWNVFDFLIVIGSIIDVILSEIDTLLASSGGLYCLGGGCGNVDPDESARISSAF 521
Query: 3640 FRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVAL 3819
FRLFRVMRL+KLLSR EG+RTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+A+
Sbjct: 522 FRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIAM 581
Query: 3820 DDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNE 3999
D T I+RNNNF +FP A+L+LFR ATGEAWQ+I+L+CS + RCDP SD Y G E
Sbjct: 582 VDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGK--RCDPESD-YAPG--EE 636
Query: 4000 SRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEY 4179
CG NFAY YFISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF +W+EY
Sbjct: 637 YACGTNFAYYYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAEY 696
Query: 4180 DPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFA 4359
DP+AKGRIKHLDVVTLLR+I PPLGFGK CPHR+ACKRLV MNMPLNSDGTV FNATLFA
Sbjct: 697 DPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFA 756
Query: 4360 LVRTNLKIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFL 4539
LVRT LKI TEGN ++ANE+LR+ IK+IWKRT LLD+V+PP G +D+VTVGKFYATFL
Sbjct: 757 LVRTALKIKTEGNFEQANEELRAIIKKIWKRTSMKLLDQVIPPIG-DDEVTVGKFYATFL 815
Query: 4540 IQDYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTL-HEIGPELKRAISGNLETDFNFD 4716
IQ++FR+F KR+E E G P + + +QAGLRT+ E PE+ RAISG+L + +
Sbjct: 816 IQEHFRKFMKRQE-EYYGYRPKK--DTVQIQAGLRTIEEEAAPEIHRAISGDLTAEEELE 872
Query: 4717 E-------PEPQHRRPHSLFNNLVHRLSGAGSKSPT------------EHERIEKGSTLL 4839
E RR LF + + L S P E E +E L
Sbjct: 873 RAMVEAAMEEGIFRRTGGLFGQVDNFLERTNSLPPVMANQRPLQFAEMEMEELESPVFLE 932
Query: 4840 PFQPRSFSPTHSLAGAEGSPVPSQM------HRGAPINQSI 4944
F TH LA A + + + HR +P+ SI
Sbjct: 933 DFPQN--PGTHPLARANTNNANANVAYGNSSHRNSPVFSSI 971
Score = 127 bits (318), Expect = 4e-27
Identities = 103/343 (30%), Positives = 159/343 (46%), Gaps = 12/343 (3%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V N IR LC IV F IL I + AL
Sbjct: 44 RPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAAL 103
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P A +N +LE +YVF VFT+E VLK+ G H ++ RN +NILD +
Sbjct: 104 AAEDPIRADSM--RNQILEYFDYVFTAVFTVEIVLKMTTYGAFLHKGSFCRNYFNILDLL 161
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S L +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 162 VVAVSLISMGLESSAIS--VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIV 219
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLT 855
L+ + ++A IG++LF GK +S C D L++ C G + + D T
Sbjct: 220 LVTTLLQFMFACIGVQLFKGKFYS-CND-----LSKMTEEEC----RGYYYIYKDGDP-T 268
Query: 856 NMGVRWECSSNTTWPGPNNGITN---FDNFGLAMLTVFQCVSLEGWTDVMYWVNDA---- 1014
+ +R P I N FDN AM+++F + EGW ++Y D+
Sbjct: 269 QIELR-----------PRQWIHNDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNEED 317
Query: 1015 -----VGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKERE 1128
R I+F+ +IL +FF++N+ +G + F ++ E
Sbjct: 318 TGPVYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGE 360
Score = 94.0 bits (232), Expect = 4e-17
Identities = 79/336 (23%), Positives = 142/336 (41%), Gaps = 39/336 (11%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP + +V FE+L+ +I N I L + Q Y S+ N + + + F ++F
Sbjct: 392 NPYQYQVWYVVTSSYFEYLMFALIMLNTICLGM-QHY--NQSEQMNHISDILNVAFTIIF 448
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKM-----SIQGF----- 552
T+E +LK++A F P Y + WN+ DF+IV+ ++ ILS++ S G
Sbjct: 449 TLEMILKLIA----FKPRGYFGDPWNVFDFLIVIGSIIDVILSEIDTLLASSGGLYCLGG 504
Query: 553 -------DVKA------LRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFV 693
D A R FRV+R ++L+S ++ +L +++ L ++ALL++ +
Sbjct: 505 GCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVML 564
Query: 694 ILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRW 873
IYA+IG+++F G++A D T
Sbjct: 565 FFIYAVIGMQMF-------------GKIAMVDGTQI------------------------ 587
Query: 874 ECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVN--------------- 1008
N NF F A+L +F+C + E W +++ +
Sbjct: 588 ------------NRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKRCDPESDYAPGE 635
Query: 1009 -DAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
A G + + YF++ +L +F ++NL + V+ F
Sbjct: 636 EYACGTNFAYYYFISFYMLCAFLIINLFVAVIMDNF 671
Score = 73.6 bits (179), Expect = 5e-11
Identities = 57/247 (23%), Positives = 98/247 (39%), Gaps = 34/247 (13%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HY QSE ++H + N+ F I+F++EM+LK+ + Y +N FD +VI SI++
Sbjct: 425 QHYNQSEQMNHISDILNVAFTIIFTLEMILKLIAFKPRGYFGDPWNVFDFLIVIGSIIDV 484
Query: 1657 VLVYFDLM----------------------KPLGVSVLRSARLLRIFKVTKYWTXXXXXX 1770
+L D + + + R R++R+ K+
Sbjct: 485 ILSEIDTLLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLL 544
Query: 1771 XXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVF 1950
GMQ+FG + Q NF TF QA+L +F
Sbjct: 545 WTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIAMVDGTQINRNNNFQTFPQAVLLLF 604
Query: 1951 QILTGEDWNTVMY----------HGIESFGGVGTLGVIVCIYYIVLF--ICGNYILLNVF 2094
+ TGE W ++ + G G YY + F +C ++++N+F
Sbjct: 605 RCATGEAWQEILLACSYGKRCDPESDYAPGEEYACGTNFAYYYFISFYMLCA-FLIINLF 663
Query: 2095 LAIAVDN 2115
+A+ +DN
Sbjct: 664 VAVIMDN 670
Score = 40.8 bits (94), Expect = 0.38
Identities = 47/230 (20%), Positives = 87/230 (37%), Gaps = 38/230 (16%)
Frame = +1
Query: 1534 FVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSV 1701
F +F++E++LKM + G ++ + FN D VV S++ L + V +
Sbjct: 126 FTAVFTVEIVLKMTTYGAFLHKGSFCRNYFNILDLLVVAVSLISMGLESSAISV---VKI 182
Query: 1702 LRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF- 1878
LR R+LR + G+Q+F GKF
Sbjct: 183 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVLVTTLLQFMFACIGVQLFKGKFY 242
Query: 1879 ---------------------NFNPQQPKPRA--------NFDTFVQALLTVFQILTGED 1971
+ +P Q + R +FD + A++++F + T E
Sbjct: 243 SCNDLSKMTEEECRGYYYIYKDGDPTQIELRPRQWIHNDFHFDNVLSAMMSLFTVSTFEG 302
Query: 1972 WNTVMYHGIES----FGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
W ++Y I+S G V V + I++I+ I + ++N+F+ +
Sbjct: 303 WPQLLYKAIDSNEEDTGPVYNNRVEMAIFFIIYIILIAFFMMNIFVGFVI 352
>gi|18858375|ref|NP_571975.1| calcium channel, voltage-dependent, L
type, alpha 1C subunit [Danio rerio]
gi|15088519|gb|AAK84072.1| voltage-gated L-type calcium channel
alpha-1 subunit [Danio rerio]
Length = 2168
Score = 1014 bits (2623), Expect = 0.0
Identities = 499/833 (59%), Positives = 630/833 (74%), Gaps = 20/833 (2%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPR +S++ P+P+A + FI S +N FRV C+ +VNH+ FTN +LF IL+SS L
Sbjct: 870 RPRPLSDIQLKEKAVPMPQAKAFFIFSPSNKFRVLCHKIVNHNIFTNLILFFILLSSISL 929
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP++ +S RN IL Y DY FT +FT+EI LK+ +G HKGSFCRN FN+LD++VV
Sbjct: 930 AAEDPVKNDSFRNQILGYADYVFTGIFTIEIILKMTAYGAFLHKGSFCRNYFNILDLVVV 989
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
+VSL S +++ A++ AINRAKGLKHVVQCV VA++TIGNI++VT
Sbjct: 990 SVSLISSGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTS 1049
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQL KG FF C D SK T+AECRG YI Y+DG+ +P +R W N+DFN
Sbjct: 1050 LLQFMFACIGVQLLKGKFFYCTDTSKQTQAECRGAYILYKDGNVGEPEKAQRSWENSDFN 1109
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FD+V M++LF VSTFEGWP LLY AIDS+ ED GPI+N R +++
Sbjct: 1110 FDDVLQGMMALFAVSTFEGWPGLLYRAIDSHAEDVGPIYNYRVVISIFFIIYIIIIAFFM 1169
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N QY+VW+ V
Sbjct: 1170 MNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKVWYVVN 1229
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F +I++NT+ LA +H+ S+ F +++ N++FTG+F E +LK++A P++
Sbjct: 1230 STYFEYLMFTLILLNTICLAMQHHGQSQSFNKAMNILNMLFTGLFTVEMILKLIAFKPRH 1289
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGGTNL--------------------ISINFFR 3645
Y D WN FD L+VVGS +DI ++NP + ISI FFR
Sbjct: 1290 YFVDAWNTFDALIVVGSVVDIAITEVNPADPSSSPPSSVVRPMGLQNTEDNARISITFFR 1349
Query: 3646 LFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDD 3825
LFRVMRLVKLLSRGEGIRTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL D
Sbjct: 1350 LFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALRD 1409
Query: 3826 STSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESR 4005
++ I+RNNNF +FP A+L+LFR ATGEAWQ+IML+CS C+ S+ H +
Sbjct: 1410 NSQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACSPNRP--CEKGSEINH----SSED 1463
Query: 4006 CGNNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDP 4185
CG++FA YF+SF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+W+EYDP
Sbjct: 1464 CGSHFAIFYFVSFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDP 1523
Query: 4186 DAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALV 4365
+AKGRIKHLDVVTLLR+I PPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFALV
Sbjct: 1524 EAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALV 1583
Query: 4366 RTNLKIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQ 4545
RT L+I TEGN+++ANE+LR+ +K+IWKRT LLD+VVPPAG +D+VTVGKFYATFLIQ
Sbjct: 1584 RTALRIETEGNLEQANEELRAIVKKIWKRTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQ 1642
Query: 4546 DYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETD 4704
+YFR+FKKRKE +P +T A++LQAGLRTLH++GPE++RAISG+L +
Sbjct: 1643 EYFRKFKKRKEQGLVAKIPPKT--ALSLQAGLRTLHDMGPEIRRAISGDLTVE 1693
Score = 696 bits (1797), Expect = 0.0
Identities = 369/699 (52%), Positives = 451/699 (63%), Gaps = 29/699 (4%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXX-XXXNNPIRKLCISIVEWKPFEFLILFMICANCIA 312
+KR KP +Q + NPIR+ CI+IVEWKPFE +IL I ANC+A
Sbjct: 91 RKRQHYTKPKKQASTASTRPPRALLCLTLKNPIRRACINIVEWKPFEIIILMTIFANCVA 150
Query: 313 LAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDF 492
LA+Y P+P DS+ N+ LE +EY F+++FT+E LK++A G + HP+AYLRN WN+LDF
Sbjct: 151 LAVYIPFPEDDSNATNSNLERVEYGFLIIFTVEAFLKVIAYGLLCHPNAYLRNGWNLLDF 210
Query: 493 IIVVIGLVSTILSKMS-----------IQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNA 639
IIVV+GL S IL + + GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+
Sbjct: 211 IIVVVGLFSAILEQATKGDGGTSMGGKAAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNS 270
Query: 640 ILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI---DPATGQLAQKDPTPCGTD 810
I++AM+PLLHIALLVLFVI+IYAIIGLELF GK+H TC D G +A++ P PC
Sbjct: 271 IIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHRTCFFYKDGHKGHIAEEKPAPCAPS 330
Query: 811 TEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTD 990
+ P+ + MG W GPN+GITNFDNF AMLTVFQC+++EGWTD
Sbjct: 331 SAHGRHCSPPNITQCMMG----------WEGPNDGITNFDNFAFAMLTVFQCITMEGWTD 380
Query: 991 VMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREK 1170
V+YW+ DA+G E PW+YFV+LVI GSFFVLNLVLGVLSGEFSKEREKA+ARG FQK RE+
Sbjct: 381 VLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLRER 440
Query: 1171 QQLEEDLKGYLDWITQAEDIEPVNEDEQEDE--------PVAQTXXXXXXXXXXXXXXXX 1326
QQLEEDLKGYLDWITQAEDI+P N+DE D+ P ++
Sbjct: 441 QQLEEDLKGYLDWITQAEDIDPENDDEGLDDDKPRNLSMPASENESVNTDNAPAGDMEGE 500
Query: 1327 XXPSKWAARMKRLE------KLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYG 1488
++ A R+ + + + N VKS FYW SEH+
Sbjct: 501 TCCTRMANRISKSKFSRYSRRWNRLCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHHQ 560
Query: 1489 QSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVY 1668
Q EWL + Q +AN + LF+ EMLLKMYSLG Y S FNRFD FVV ILE +LV
Sbjct: 561 QPEWLTNVQDIANKVLLALFTGEMLLKMYSLGLQAYFVSLFNRFDSFVVCGGILETILVE 620
Query: 1669 FDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1848
+M PLG+SVLR RLLRIFK+T+YW
Sbjct: 621 TKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSL 680
Query: 1849 XGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLG 2028
GMQ+FGGKFNF+ + R+ FD F Q+LLTVFQILTGEDWN+VMY GI ++GG G
Sbjct: 681 LGMQLFGGKFNFDETR---RSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPG 737
Query: 2029 VIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNA 2145
++VCIY+I+LFICGNYILLNVFLAIAVDNLADA+SLT+A
Sbjct: 738 MLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSA 776
Score = 124 bits (311), Expect = 3e-26
Identities = 93/342 (27%), Positives = 163/342 (47%), Gaps = 10/342 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V +N R LC IV F LILF I + I+L
Sbjct: 870 RPRPLSDIQLKEKAVPMPQAKAFFIFSPSNKFRVLCHKIVNHNIFTNLILFFILLSSISL 929
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P ++ ++N +L +YVF +FTIE +LK+ A G H ++ RN +NILD +
Sbjct: 930 AAEDP--VKNDSFRNQILGYADYVFTGIFTIEIILKMTAYGAFLHKGSFCRNYFNILDLV 987
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S+ + +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 988 VVSVSLISSGIQSSAINV--VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIV 1045
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLT 855
++ + ++A IG++L GK C ++ + +C+ + L
Sbjct: 1046 IVTSLLQFMFACIGVQLLKGKFFY-----------------CTDTSKQTQAECRGAYILY 1088
Query: 856 NMGVRWECS-SNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDA----VG 1020
G E + +W N NFD+ M+ +F + EGW ++Y D+ VG
Sbjct: 1089 KDGNVGEPEKAQRSW---ENSDFNFDDVLQGMMALFAVSTFEGWPGLLYRAIDSHAEDVG 1145
Query: 1021 REWPW-----IYFVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
+ + I+F+ +I+ +FF++N+ +G + F ++ E+
Sbjct: 1146 PIYNYRVVISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1187
Score = 96.3 bits (238), Expect = 8e-18
Identities = 63/258 (24%), Positives = 124/258 (47%), Gaps = 4/258 (1%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S F +++ ++ +NT+++A +H+ + D+ N + +F E +LK+ +L
Sbjct: 534 VKSNVFYWLVIFLVFLNTLTIASEHHQQPEWLTNVQDIANKVLLALFTGEMLLKMYSLGL 593
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD VV G ++ + + + I+ R R++R+ K+ +
Sbjct: 594 QAYFVSLFNRFDSFVVCGGILETILVETKI--MSPLGISVLRCVRLLRIFKITRYWNSLS 651
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAIL 3879
L+ + + S +++ + LL+ L I++++GMQ FG D T R + F +FP ++L
Sbjct: 652 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDET---RRSTFDNFPQSLL 708
Query: 3880 VLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNF----AYPYFISFF 4047
+F+ TGE W +M D G G +F YFI F
Sbjct: 709 TVFQILTGEDWNSVMY--------------DGIMAYG------GPSFPGMLVCIYFIILF 748
Query: 4048 MLCSFLVINLFVAVIMDN 4101
+ +++++N+F+A+ +DN
Sbjct: 749 ICGNYILLNVFLAIAVDN 766
Score = 91.7 bits (226), Expect = 2e-16
Identities = 80/282 (28%), Positives = 116/282 (40%), Gaps = 27/282 (9%)
Frame = +1
Query: 2296 ASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANS 2475
AST P + L L+ N R C +V F +L I + LA P +
Sbjct: 103 ASTASTRPPRA-LLCLTLKNPIRRACINIVEWKPFEIIILMTIFANCVALAVYIPFPEDD 161
Query: 2476 TR--NMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFV 2649
+ N L +Y F +FTVE LKVI +GL+ H ++ RN +NLLD ++V V L S +
Sbjct: 162 SNATNSNLERVEYGFLIIFTVEAFLKVIAYGLLCHPNAYLRNGWNLLDFIIVVVGLFSAI 221
Query: 2650 LRTDAMSXXXXXXXXXXXXXXXAINRA-------------KGLKHVVQCVIVAVKTIGNI 2790
L RA L+ V+ +I A+ + +I
Sbjct: 222 LEQATKGDGGTSMGGKAAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHI 281
Query: 2791 MLVTFMLQFMFAIIGVQLFKG----TFFLCND-----LSKMTEAECRGEYIHYEDGDPTK 2943
L+ + ++AIIG++LF G T F D +++ A C H P
Sbjct: 282 ALLVLFVIIIYAIIGLELFMGKMHRTCFFYKDGHKGHIAEEKPAPCAPSSAHGRHCSPPN 341
Query: 2944 PVSKKRVWSN-ND--FNFDNVGDAMISLFVVSTFEGWPQLLY 3060
W ND NFDN AM+++F T EGW +LY
Sbjct: 342 ITQCMMGWEGPNDGITNFDNFAFAMLTVFQCITMEGWTDVLY 383
Score = 86.7 bits (213), Expect = 6e-15
Identities = 77/335 (22%), Positives = 139/335 (40%), Gaps = 38/335 (11%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP + +V FE+L+ +I N I LA+ +Q N + + +F +F
Sbjct: 1218 NPYQYKVWYVVNSTYFEYLMFTLILLNTICLAMQHHGQSQSF---NKAMNILNMLFTGLF 1274
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLV-----------------STILS 531
T+E +LK++A F P Y +AWN D +IVV +V S+++
Sbjct: 1275 TVEMILKLIA----FKPRHYFVDAWNTFDALIVVGSVVDIAITEVNPADPSSSPPSSVVR 1330
Query: 532 KMSIQGFDVKA------LRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFV 693
M +Q + A R FRV+R ++L+S ++ +L +++ L ++ALL++ +
Sbjct: 1331 PMGLQNTEDNARISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVML 1390
Query: 694 ILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRW 873
IYA+IG+++F G++A +D +
Sbjct: 1391 FFIYAVIGMQMF-------------GKIALRDNSQI------------------------ 1413
Query: 874 ECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMY---------------WVN 1008
N NF F A+L +F+C + E W ++M +
Sbjct: 1414 ------------NRNNNFQTFPQAVLLLFRCATGEAWQEIMLACSPNRPCEKGSEINHSS 1461
Query: 1009 DAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
+ G + YFV+ +L +F ++NL + V+ F
Sbjct: 1462 EDCGSHFAIFYFVSFYMLCAFLIINLFVAVIMDNF 1496
Score = 82.0 bits (201), Expect = 1e-13
Identities = 87/356 (24%), Positives = 145/356 (40%), Gaps = 57/356 (16%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVAL-- 3513
+ FE +I + I N V+LA +P S L+ F +F EA LK++A
Sbjct: 134 KPFEIIILMTIFANCVALAVYIPFPEDDSNATNSNLERVEYGFLIIFTVEAFLKVIAYGL 193
Query: 3514 --NPKNYISDRWNVFD-LLVVVGSFIDIT-YGKLNPGGTNL------ISINFFRLFRVMR 3663
+P Y+ + WN+ D ++VVVG F I GGT++ + R FRV+R
Sbjct: 194 LCHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKGDGGTSMGGKAAGFDVKALRAFRVLR 253
Query: 3664 LVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF------------- 3804
++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F
Sbjct: 254 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHRTCFFYKD 313
Query: 3805 ---GKVALDD-----STSIHRNN---------------------NFHSFPAAILVLFRSA 3897
G +A + +S H + NF +F A+L +F+
Sbjct: 314 GHKGHIAEEKPAPCAPSSAHGRHCSPPNITQCMMGWEGPNDGITNFDNFAFAMLTVFQCI 373
Query: 3898 TGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINL 4077
T E W D++ D G + YF+S + SF V+NL
Sbjct: 374 TMEGWTDVLYWMQD---------------------AMGYELPWVYFVSLVIFGSFFVLNL 412
Query: 4078 FVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
+ V+ F G + +R + + D KG +LD +T I P
Sbjct: 413 VLGVLSGEFSKEREKAKARGDF---QKLRERQQLEEDLKG---YLDWITQAEDIDP 462
Score = 72.0 bits (175), Expect = 2e-10
Identities = 56/246 (22%), Positives = 101/246 (40%), Gaps = 33/246 (13%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+H+GQS+ + + N+ F LF++EM+LK+ + Y +N FD +V+ S+++
Sbjct: 1251 QHHGQSQSFNKAMNILNMLFTGLFTVEMILKLIAFKPRHYFVDAWNTFDALIVVGSVVDI 1310
Query: 1657 VLVYFD-----------LMKPLG-----------VSVLRSARLLRIFKVTKYWTXXXXXX 1770
+ + +++P+G ++ R R++R+ K+
Sbjct: 1311 AITEVNPADPSSSPPSSVVRPMGLQNTEDNARISITFFRLFRVMRLVKLLSRGEGIRTLL 1370
Query: 1771 XXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVF 1950
GMQ+FG + Q NF TF QA+L +F
Sbjct: 1371 WTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALRDNSQINRNNNFQTFPQAVLLLF 1430
Query: 1951 QILTGEDWNTVMY---------HGIESFGGVGTLGVIVCIYYIVLF--ICGNYILLNVFL 2097
+ TGE W +M G E G I+Y V F +C ++++N+F+
Sbjct: 1431 RCATGEAWQEIMLACSPNRPCEKGSEINHSSEDCGSHFAIFYFVSFYMLCA-FLIINLFV 1489
Query: 2098 AIAVDN 2115
A+ +DN
Sbjct: 1490 AVIMDN 1495
Score = 42.7 bits (99), Expect = 0.10
Identities = 18/70 (25%), Positives = 38/70 (53%), Gaps = 4/70 (5%)
Frame = +1
Query: 1912 NFDTFVQALLTVFQILTGEDWNTVMYHGIES----FGGVGTLGVIVCIYYIVLFICGNYI 2079
NFD +Q ++ +F + T E W ++Y I+S G + V++ I++I+ I +
Sbjct: 1109 NFDDVLQGMMALFAVSTFEGWPGLLYRAIDSHAEDVGPIYNYRVVISIFFIIYIIIIAFF 1168
Query: 2080 LLNVFLAIAV 2109
++N+F+ +
Sbjct: 1169 MMNIFVGFVI 1178
>gi|508189|emb|CAA84350.1| voltage-dependent L-type Ca channel alpha 1
subunit [Homo sapiens]
Length = 2166
Score = 1014 bits (2622), Expect = 0.0
Identities = 510/858 (59%), Positives = 640/858 (74%), Gaps = 40/858 (4%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPR +SE+ P+P+AS+ FI S N FR+ C+ +VN + FTN +LF IL+SS L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP+Q S RN IL YFD FT++FT+EI LK+ +G HKGSFCRN FN+LD+LVV
Sbjct: 918 AAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVV 977
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
+VSL SF +++ A++ AINRAKGLKHVVQCV VA++TIGNI++VT
Sbjct: 978 SVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 1037
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG + C+D SK TEAEC+G YI Y+DG+ P+ + R W N+ F+
Sbjct: 1038 LLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFD 1097
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP+LLY +IDS+ EDKGPI+N R +++
Sbjct: 1098 FDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFM 1157
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N+ QY+VW+ V
Sbjct: 1158 MNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVN 1217
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S F+ +++ N++FTG+F E +LK++A PK
Sbjct: 1218 STYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKG 1277
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGK----------------------------------- 3600
Y SD WNVFD L+V+GS ID+ +
Sbjct: 1278 YFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHT 1337
Query: 3601 -----LNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVL 3765
+N + ISI FFRLFRVMRLVKLLSRGEGIRTLLWTF+KSFQALPYVALLIV+
Sbjct: 1338 QCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVM 1397
Query: 3766 LFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDRE 3945
LFFIYAVIGMQ FGK+AL+D+T I+RNNNF +FP A+L+LFR ATGEAWQDIML+C +
Sbjct: 1398 LFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGK 1457
Query: 3946 DVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDW 4125
+C P S+ + E+ CG++FA YFISF+MLC+FL+INLFVAVIMDNFDYLTRDW
Sbjct: 1458 --KCAPESEPSNSTE-GETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDW 1514
Query: 4126 SILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSM 4305
SILGPHHL+EF R+W+EYDP+AKGRIKHLDVVTLLR+I PPLGFGKLCPHR+ACKRLVSM
Sbjct: 1515 SILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSM 1574
Query: 4306 NMPLNSDGTVCFNATLFALVRTNLKIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVP 4485
NMPLNSDGTV FNATLFALVRT L+I TEGN+++ANE+LR+ IK+IWKRT LLD+VVP
Sbjct: 1575 NMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVP 1634
Query: 4486 PAGKEDDVTVGKFYATFLIQDYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGP 4665
PAG +D+VTVGKFYATFLIQ+YFR+FKKRKE G P+Q A++LQAGLRTLH+IGP
Sbjct: 1635 PAG-DDEVTVGKFYATFLIQEYFRKFKKRKEQGLVG-KPSQR-NALSLQAGLRTLHDIGP 1691
Query: 4666 ELKRAISGNLETDFNFDE 4719
E++RAISG+L + D+
Sbjct: 1692 EIRRAISGDLTAEEELDK 1709
Score = 722 bits (1863), Expect = 0.0
Identities = 383/698 (54%), Positives = 459/698 (64%), Gaps = 28/698 (4%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXX-XXXNNPIRKLCISIVEWKPFEFLILFMICANCIA 312
+KR KP +Q + NPIR+ CISIVEWKPFE +IL I ANC+A
Sbjct: 81 RKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVA 140
Query: 313 LAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDF 492
LAIY P+P DS+ N+ LE +EY+F+++FT+E LK++A G +FHP+AYLRN WN+LDF
Sbjct: 141 LAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDF 200
Query: 493 IIVVIGLVSTILSKMSIQ-----------GFDVKALRAFRVLRPLRLVSGVPSLQVVLNA 639
IIVV+GL S IL + + GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+
Sbjct: 201 IIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNS 260
Query: 640 ILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPA--TGQLAQKDPTPCGTDT 813
I++AM+PLLHIALLVLFVI+IYAIIGLELF GK+H TC + A+ DP+PC +T
Sbjct: 261 IIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALET 320
Query: 814 EGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDV 993
G +CQ + ++ G W GP +GITNFDNF AMLTVFQC+++EGWTDV
Sbjct: 321 -GHGRQCQ-NGTVCKPG----------WDGPKHGITNFDNFAFAMLTVFQCITMEGWTDV 368
Query: 994 MYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQ 1173
+YWVNDAVGR+WPWIYFVTL+I+GSFFVLNLVLGVLSGEFSKEREKA+ARG FQK REKQ
Sbjct: 369 LYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 428
Query: 1174 QLEEDLKGYLDWITQAEDIEPVNEDEQEDE--------PVAQTXXXXXXXXXXXXXXXXX 1329
QLEEDLKGYLDWITQAEDI+P NEDE DE P ++T
Sbjct: 429 QLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGEN 488
Query: 1330 XPSKWAARMKRLE------KLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQ 1491
++ A R+ + + + N VKS FYW SEHY Q
Sbjct: 489 CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQ 548
Query: 1492 SEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYF 1671
WL Q AN + LF+ EMLLKMYSLG Y S FNRFDCFVV ILE +LV
Sbjct: 549 PNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+M PLG+SVLR RLLRIFK+T+YW
Sbjct: 609 KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668
Query: 1852 GMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGV 2031
GMQ+FGGKFNF+ Q + R+ FD F Q+LLTVFQILTGEDWN+VMY GI ++GG G+
Sbjct: 669 GMQLFGGKFNFDEMQTR-RSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGM 727
Query: 2032 IVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNA 2145
+VCIY+I+LFICGNYILLNVFLAIAVDNLADA+SLT+A
Sbjct: 728 LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSA 765
Score = 127 bits (320), Expect = 2e-27
Identities = 100/342 (29%), Positives = 160/342 (46%), Gaps = 10/342 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V NN R C IV F LILF I + I+L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P Q + ++N +L + VF +FTIE LK+ A G H ++ RN +NILD +
Sbjct: 918 AAEDP--VQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLL 975
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S + +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 976 VVSVSLISFGIQSSAINV--VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIV 1033
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ-KDPTPCGTDTEGSAFKCQPSDSL 852
++ + ++A IG++LF GKL+ TC D + A+ K D E QP
Sbjct: 1034 IVTTLLQFMFACIGVQLFKGKLY-TCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRS-- 1090
Query: 853 TNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWP 1032
WE N +FDN AM+ +F + EGW +++Y D+ +
Sbjct: 1091 ------WE-----------NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKG 1133
Query: 1033 WIY---------FVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
IY F+ +I+ +FF++N+ +G + F ++ E+
Sbjct: 1134 PIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1175
Score = 95.9 bits (237), Expect = 1e-17
Identities = 64/259 (24%), Positives = 124/259 (47%), Gaps = 5/259 (1%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S F +++ ++ +NT+++A +HY + D N +F E +LK+ +L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD VV G ++ + + + I+ R R++R+ K+ +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL--VETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + + S +++ + LL+ L I++++GMQ F GK D+ + R + F +FP ++
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT--RRSTFDNFPQSL 696
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNF----AYPYFISF 4044
L +F+ TGE W +M D G G +F YFI
Sbjct: 697 LTVFQILTGEDWNSVMY--------------DGIMAYG------GPSFPGMLVCIYFIIL 736
Query: 4045 FMLCSFLVINLFVAVIMDN 4101
F+ +++++N+F+A+ +DN
Sbjct: 737 FICGNYILLNVFLAIAVDN 755
Score = 90.9 bits (224), Expect = 3e-16
Identities = 88/353 (24%), Positives = 148/353 (40%), Gaps = 54/353 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE +I L I N V+LA +P S L+ +F +F EA LK++A
Sbjct: 124 KPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGL 183
Query: 3511 -LNPKNYISDRWNVFD-LLVVVGSFIDITYGKLNPGGTNLIS-------INFFRLFRVMR 3663
+P Y+ + WN+ D ++VVVG F I G N + + R FRV+R
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLR 243
Query: 3664 LVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV--------- 3813
++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F GK+
Sbjct: 244 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEG 303
Query: 3814 -----ALDDSTSI------------------------HRNNNFHSFPAAILVLFRSATGE 3906
A DD + H NF +F A+L +F+ T E
Sbjct: 304 IADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITME 363
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVA 4086
W D++ +D G ++ + YF++ ++ SF V+NL +
Sbjct: 364 GWTDVLYWVND---------------------AVGRDWPWIYFVTLIIIGSFFVLNLVLG 402
Query: 4087 VIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
V+ F G + +R + + D KG +LD +T I P
Sbjct: 403 VLSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 449
Score = 89.0 bits (219), Expect = 1e-15
Identities = 77/282 (27%), Positives = 122/282 (42%), Gaps = 29/282 (10%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR--NMILNYF 2502
+L L+ N R C +V F +L I + LA P + + N L
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL----RTDAMS 2670
+Y F +FTVE LKVI +GL+FH ++ RN +NLLD ++V V L S +L + D +
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 2671 XXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
A ++ L+ V+ +I A+ + +I L+ + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 2824 AIIGVQLFKGTFF-LCNDLSKMTE-------AECRGEYIH---YEDGDPTKPVSKKRVW- 2967
AIIG++LF G C + + + + C E H ++G KP W
Sbjct: 283 AIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKP-----GWD 337
Query: 2968 --SNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEED 3087
+ NFDN AM+++F T EGW +LY D+ D
Sbjct: 338 GPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRD 379
Score = 79.7 bits (195), Expect = 7e-13
Identities = 75/343 (21%), Positives = 132/343 (37%), Gaps = 61/343 (17%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+L+ +I N I LA+ Q Y Q +K + + +F +FT+E +LK++A F
Sbjct: 1221 FEYLMFVLILLNTICLAM-QHY-GQSCLFK-IAMNILNMLFTGLFTVEMILKLIA----F 1273
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD------------------------ 555
P Y + WN+ DF+IV+ ++ ILS+ + D
Sbjct: 1274 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNP 1333
Query: 556 -------------------VKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIAL 678
+ R FRV+R ++L+S ++ +L +++ L ++AL
Sbjct: 1334 AEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVAL 1393
Query: 679 LVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTN 858
L++ + IYA+IG+++F G++A D T
Sbjct: 1394 LIVMLFFIYAVIGMQVF-------------GKIALNDTTEI------------------- 1421
Query: 859 MGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWV----------- 1005
N NF F A+L +F+C + E W D+M
Sbjct: 1422 -----------------NRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESE 1464
Query: 1006 -------NDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
G + YF++ +L +F ++NL + V+ F
Sbjct: 1465 PSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1507
Score = 62.4 bits (150), Expect = 1e-07
Identities = 60/268 (22%), Positives = 100/268 (36%), Gaps = 55/268 (20%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HYGQS + N+ F LF++EM+LK+ + Y + +N FD +VI SI++
Sbjct: 1239 QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDV 1298
Query: 1657 VLVY-----------FDLMKPLG-------------------------------VSVLRS 1710
+L FD + +G ++ R
Sbjct: 1299 ILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRL 1358
Query: 1711 ARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNP 1890
R++R+ K+ GMQVFG +
Sbjct: 1359 FRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDT 1418
Query: 1891 QQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGI-------ESFGGVGTLGVIVC--- 2040
+ NF TF QA+L +F+ TGE W +M + ES T G C
Sbjct: 1419 TEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSS 1478
Query: 2041 ---IYYIVLFICGNYILLNVFLAIAVDN 2115
Y+I ++ ++++N+F+A+ +DN
Sbjct: 1479 FAVFYFISFYMLCAFLIINLFVAVIMDN 1506
Score = 41.2 bits (95), Expect = 0.29
Identities = 46/240 (19%), Positives = 87/240 (36%), Gaps = 38/240 (15%)
Frame = +1
Query: 1504 DHFQTMANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYF 1671
+H ++ F +F++E+ LKM + G ++ + FN D VV S++ F +
Sbjct: 930 NHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS 989
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+ V +LR R+LR +
Sbjct: 990 AINV---VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACI 1046
Query: 1852 GMQVFGGKFNFNPQQPK------------------------PRA------NFDTFVQALL 1941
G+Q+F GK K PR+ +FD + A++
Sbjct: 1047 GVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMM 1106
Query: 1942 TVFQILTGEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+F + T E W ++Y I+S G + V + I++I+ I + ++N+F+ +
Sbjct: 1107 ALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1166
>gi|92951|pir||JH0422 voltage-dependent calcium channel complex
alpha-1 chain - rat
gi|206574|gb|AAA42015.1| calcium channel alpha-1 subunit
Length = 1646
Score = 1014 bits (2621), Expect = 0.0
Identities = 504/805 (62%), Positives = 614/805 (75%), Gaps = 16/805 (1%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPRR+SE+ + PIP+ S+ FILS TN RV C+ ++NH FTN +L I++SSA L
Sbjct: 843 RPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAAL 902
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP++++S RN IL YFDY FT++FTVEI LK+ FG HKG+FCRN FNLLD+LVV
Sbjct: 903 AAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVV 962
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
VSL SF +++ A+S AINRAKGLKHVVQCV VA++TIGNIM+VT
Sbjct: 963 GVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTT 1022
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG F+ C D +K ECRG +I Y+DGD PV ++R+W N+DFN
Sbjct: 1023 LLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFN 1082
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP LLY AIDSN E+ GP++N R +++
Sbjct: 1083 FDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENVGPVYNYRVEISIFFIIYIIIVAFFM 1142
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N QY+ W+ V
Sbjct: 1143 MNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVN 1202
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S+ F D +D+ N++FTGVF E VLK++A PK
Sbjct: 1203 SSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKG 1262
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGGT----------------NLISINFFRLFRV 3657
Y SD WN FD L+V+GS ID+ + +P + N ISI FFRLFRV
Sbjct: 1263 YFSDAWNTFDSLIVIGSIIDVALSEADPSDSENIPLPTATPGNSEESNRISITFFRLFRV 1322
Query: 3658 MRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSI 3837
MRLVKLLSRGEGIRTLLWTF+KSFQALPYVALLI +LFFIYAVIGMQ FGKVA+ D+ I
Sbjct: 1323 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQI 1382
Query: 3838 HRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNN 4017
+RNNNF +FP A+L+LFR ATGEAWQ+IML+C + CDP SD Y+ G E CG+N
Sbjct: 1383 NRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGK--LCDPDSD-YNPG--EEYTCGSN 1437
Query: 4018 FAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKG 4197
FA YFISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+WSEYDP+AKG
Sbjct: 1438 FAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKG 1497
Query: 4198 RIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNL 4377
RIKHLDVVTLLR+I PPLGFGKLCPHR+ACKRLV+MNMPLNSDGTV FNATLFALVRT L
Sbjct: 1498 RIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTAL 1557
Query: 4378 KIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFR 4557
KI TEGN+++ANE+LR+ IK+IWK+T LLD+VVPPAG +D+VTVGKFYATFLIQDYFR
Sbjct: 1558 KIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQDYFR 1616
Query: 4558 RFKKRKEMEAKGVLPAQTPQAMALQ 4632
+FKKRKE G PA+ +ALQ
Sbjct: 1617 KFKKRKEQGLVGKYPAKN-TTIALQ 1640
Score = 718 bits (1854), Expect = 0.0
Identities = 374/669 (55%), Positives = 448/669 (66%), Gaps = 27/669 (4%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
NNPIR+ CISIV WKPF+ IL I ANC+ALAIY P+P DS+ N LE +EY F+++
Sbjct: 111 NNPIRRACISIVNWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLII 170
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQ----------- 546
FT+E LKI+A G + HP+AY+RN WN+LDF+IV++GL S IL +++ +
Sbjct: 171 FTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKS 230
Query: 547 -GFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLE 723
GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+I++AM+PLLHIALLVLFVI+IYAIIGLE
Sbjct: 231 GGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLE 290
Query: 724 LFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPG 903
LF GK+H TC + +A++DP PC G+ +C + + EC S W G
Sbjct: 291 LFIGKMHKTCFFADSDIVAEEDPAPCAFS--GNGRQCAANGT--------ECRSG--WVG 338
Query: 904 PNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLN 1083
PN GITNFDNF AMLTVFQC+++EGWTDV+YWVNDA+G EWPW+YFV+L+ILGSFFVLN
Sbjct: 339 PNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLN 398
Query: 1084 LVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDE 1263
LVLGVLSGEFSKEREKA+ARG FQK REKQQLEEDLKGYLDWITQAEDI+P NE+E +E
Sbjct: 399 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEE 458
Query: 1264 -------PVAQTXXXXXXXXXXXXXX--------XXXXPSKWAARMKRLEKLNXXXXXXX 1398
P ++T SK + R +R + N
Sbjct: 459 GKRNTSMPTSETESVNTENVSGEGETQGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAA 518
Query: 1399 XXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYS 1578
VKS TFYW +SEHY Q +WL Q +AN + LF+ EML+KMYS
Sbjct: 519 ---VKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYS 575
Query: 1579 LGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXX 1758
LG Y S FNRFDCFVV I E +LV +LM PLGVSV R RLLRIFKVT++WT
Sbjct: 576 LGLQAYFVSLFNRFDCFVVCGGITETILVELELMSPLGVSVFRCVRLLRIFKVTRHWTSL 635
Query: 1759 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQAL 1938
GMQ+FGGKFNF+ Q K R+ FD F QAL
Sbjct: 636 SNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTK-RSTFDNFPQAL 694
Query: 1939 LTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNL 2118
LTVFQILTGEDWN VMY GI ++GG + G+IVCIY+I+LFICGNYILL +FLAIAVDNL
Sbjct: 695 LTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLKLFLAIAVDNL 754
Query: 2119 ADADSLTNA 2145
ADA+SL A
Sbjct: 755 ADAESLNTA 763
Score = 128 bits (322), Expect = 1e-27
Identities = 92/312 (29%), Positives = 152/312 (48%), Gaps = 9/312 (2%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR C ++ F LIL I + ALA P + ++NT+L +Y F +F
Sbjct: 872 NPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPI--RSHSFRNTILGYFDYAFTAIF 929
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
T+E +LK+ G H A+ RN +N+LD ++V + LVS + +I VK LR RV
Sbjct: 930 TVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAIS--VVKILRVLRV 987
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLR ++ L+ V+ + A+ + +I ++ + ++A IG++LF GK + C D
Sbjct: 988 LRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFY-RCTDE 1046
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
A+ +P C F + + VR N+ + NFDN
Sbjct: 1047 -----AKSNPEEC-----RGLFILYKDGDVDSPVVRERIWQNSDF--------NFDNVLS 1088
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDAVG---------REWPWIYFVTLVILGSFFVLNLVLG 1095
AM+ +F + EGW ++Y D+ G R I+F+ +I+ +FF++N+ +G
Sbjct: 1089 AMMALFTVSTFEGWPALLYKAIDSNGENVGPVYNYRVEISIFFIIYIIIVAFFMMNIFVG 1148
Query: 1096 VLSGEFSKEREK 1131
+ F ++ EK
Sbjct: 1149 FVIVTFQEQGEK 1160
Score = 101 bits (252), Expect = 2e-19
Identities = 70/276 (25%), Positives = 133/276 (47%), Gaps = 1/276 (0%)
Frame = +1
Query: 3277 KAKPHRRYIPRNRL-QYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDV 3453
K+K RR+ NR + R V S F +++ +++ +NT++++ +HY D+
Sbjct: 497 KSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDI 556
Query: 3454 FNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISI 3633
N + +F E ++K+ +L + Y +N FD VV G + +L + + +
Sbjct: 557 ANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEL--MSPLGV 614
Query: 3634 NFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKV 3813
+ FR R++R+ K+ + L+ + + S +++ + LL+ L I++++GMQ FG
Sbjct: 615 SVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGK 674
Query: 3814 ALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGL 3993
D T R + F +FP A+L +F+ TGE W +M GG
Sbjct: 675 FNFDETQTKR-STFDNFPQALLTVFQILTGEDWNAVM-------------YDGIMAYGGP 720
Query: 3994 NESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDN 4101
+ S YFI F+ +++++ LF+A+ +DN
Sbjct: 721 SSS---GMIVCIYFIILFICGNYILLKLFLAIAVDN 753
Score = 93.2 bits (230), Expect = 6e-17
Identities = 76/332 (22%), Positives = 136/332 (40%), Gaps = 35/332 (10%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP + +V PFE+++ +I N + LA+ Q Y + S N ++ + VF VF
Sbjct: 1191 NPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAM-QHY--EQSKMFNDAMDILNMVFTGVF 1247
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD--------- 555
T+E VLK++A F P Y +AWN D +IV+ ++ LS+ +
Sbjct: 1248 TVEMVLKVIA----FKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPSDSENIPLPTATP 1303
Query: 556 ----------VKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIY 705
+ R FRV+R ++L+S ++ +L +++ L ++ALL+ + IY
Sbjct: 1304 GNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIY 1363
Query: 706 AIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSS 885
A+IG+++F G++A +D
Sbjct: 1364 AVIGMQMF-------------GKVAMRDNNQI---------------------------- 1382
Query: 886 NTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMY----------------WVNDAV 1017
N NF F A+L +F+C + E W ++M
Sbjct: 1383 --------NRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPDSDYNPGEEYTC 1434
Query: 1018 GREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
G + +YF++ +L +F ++NL + V+ F
Sbjct: 1435 GSNFAIVYFISFYMLCAFLIINLFVAVIMDNF 1466
Score = 91.7 bits (226), Expect = 2e-16
Identities = 80/275 (29%), Positives = 122/275 (44%), Gaps = 24/275 (8%)
Frame = +1
Query: 2323 ASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPL---QANSTRNMIL 2493
A +LF LS N R C +VN F +L I + LA P +NST N L
Sbjct: 102 ARALFCLSLNNPIRRACISIVNWKPFDIFILLAIFANCVALAIYIPFPEDDSNST-NHNL 160
Query: 2494 NYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL-----RT 2658
+Y F +FTVE LK+I +GL+ H ++ RN +NLLD ++V V L S +L T
Sbjct: 161 EKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKET 220
Query: 2659 DAMSXXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFML 2811
+ + A ++ L+ V+ +I A+ + +I L+ +
Sbjct: 221 EGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFV 280
Query: 2812 QFMFAIIGVQLF-----KGTFFLCNDL-SKMTEAECRGEYIHYEDGDPTKPVSKKRVWSN 2973
++AIIG++LF K FF +D+ ++ A C + V N
Sbjct: 281 IIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCAANGTECRSGWVGPN 340
Query: 2974 NDF-NFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
NFDN AM+++F T EGW +LY D+
Sbjct: 341 GGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDA 375
Score = 91.7 bits (226), Expect = 2e-16
Identities = 146/706 (20%), Positives = 255/706 (35%), Gaps = 80/706 (11%)
Frame = +1
Query: 232 RKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIE 411
R+ C + V+ F +L++ ++ N + ++ D+ + + V + +FT E
Sbjct: 512 RRRCRAAVKSVTFYWLVIVLVFLNTLTISSEH---YNQPDWLTQIQDIANKVLLALFTCE 568
Query: 412 CVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG-FDVKALRAFRVLR 588
++K+ ++G AY + +N D +V G+ TIL ++ + V R R+LR
Sbjct: 569 MLVKMYSLGLQ----AYFVSLFNRFDCFVVCGGITETILVELELMSPLGVSVFRCVRLLR 624
Query: 589 PLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPAT 768
++ SL ++ ++L +M + + LL+ I+I++++
Sbjct: 625 IFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLL------------------ 666
Query: 769 GQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAM 948
G G F + + + FDNF A+
Sbjct: 667 -----------GMQLFGGKFNFDETQTKRS---------------------TFDNFPQAL 694
Query: 949 LTVFQCVSLEGWTDVMYWVNDAVGREWP-----WIYFVTLVILGSFFVLNLVLGVLSGEF 1113
LTVFQ ++ E W VMY A G IYF+ L I G++ +L L L +
Sbjct: 695 LTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLKLFLAIAVDNL 754
Query: 1114 S---------------KEREK-ARARGLFQKFREKQQLEE----DLKGYLD-WITQAEDI 1230
+ KER+K AR L K K ++ + D K +D + +AED
Sbjct: 755 ADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYQEEAEDK 814
Query: 1231 EPV----------NEDEQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNX 1380
+P E+E+EDEP P + L K N
Sbjct: 815 DPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIA-PIPEGSAFFILSKTNP 873
Query: 1381 XXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSE-----HYGQSEWLDHFQTMANLFFVIL 1545
L+ F +E H ++ L +F + F +
Sbjct: 874 IRVGCHK-LINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYF----DYAFTAI 928
Query: 1546 FSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSA 1713
F++E+LLKM + G + + FN D VV S++ F + + V +LR
Sbjct: 929 FTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISV---VKILRVL 985
Query: 1714 RLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF----- 1878
R+LR + G+Q+F GKF
Sbjct: 986 RVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTD 1045
Query: 1879 --NFNPQQ---------------PKPRA--------NFDTFVQALLTVFQILTGEDWNTV 1983
NP++ P R NFD + A++ +F + T E W +
Sbjct: 1046 EAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPAL 1105
Query: 1984 MYHGI----ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+Y I E+ G V V + I++I+ I + ++N+F+ +
Sbjct: 1106 LYKAIDSNGENVGPVYNYRVEISIFFIIYIIIVAFFMMNIFVGFVI 1151
Score = 83.6 bits (205), Expect = 5e-14
Identities = 82/355 (23%), Positives = 141/355 (39%), Gaps = 53/355 (14%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA 3510
V + F+ I L I N V+LA +P S L+ F +F E LKI+A
Sbjct: 122 VNWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIA 181
Query: 3511 ----LNPKNYISDRWNVFDLLVVVGSFIDITYGKL---------NPGGTNLISINFFRLF 3651
L+P Y+ + WN+ D ++V+ + +L + G + + R F
Sbjct: 182 YGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAF 241
Query: 3652 RVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF--------- 3804
RV+R ++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F
Sbjct: 242 RVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCF 301
Query: 3805 --------------------GKVALDDSTSIHRN--------NNFHSFPAAILVLFRSAT 3900
G+ + T NF +F A+L +F+ T
Sbjct: 302 FADSDIVAEEDPAPCAFSGNGRQCAANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCIT 361
Query: 3901 GEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLF 4080
E W D++ +D G + + YF+S +L SF V+NL
Sbjct: 362 MEGWTDVLYWVND---------------------AIGWEWPWVYFVSLIILGSFFVLNLV 400
Query: 4081 VAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
+ V+ F G + +R + + D KG +LD +T I P
Sbjct: 401 LGVLSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 449
Score = 67.8 bits (164), Expect = 3e-09
Identities = 53/245 (21%), Positives = 97/245 (38%), Gaps = 32/245 (13%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HY QS+ + + N+ F +F++EM+LK+ + Y + +N FD +VI SI++
Sbjct: 1224 QHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDV 1283
Query: 1657 VLVYFDLMKP------------------LGVSVLRSARLLRIFKVTKYWTXXXXXXXXXX 1782
L D + ++ R R++R+ K+
Sbjct: 1284 ALSEADPSDSENIPLPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFI 1343
Query: 1783 XXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILT 1962
GMQ+FG + Q NF TF QA+L +F+ T
Sbjct: 1344 KSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCAT 1403
Query: 1963 GEDWNTVM--------------YHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLA 2100
GE W +M Y+ E + + +Y+I ++ ++++N+F+A
Sbjct: 1404 GEAWQEIMLACLPGKLCDPDSDYNPGEEYTCGSNFAI---VYFISFYMLCAFLIINLFVA 1460
Query: 2101 IAVDN 2115
+ +DN
Sbjct: 1461 VIMDN 1465
>gi|508201|emb|CAA84344.1| voltage-dependent L-type Ca channel alpha 1
subunit [Homo sapiens]
Length = 2146
Score = 1014 bits (2621), Expect = 0.0
Identities = 510/838 (60%), Positives = 638/838 (75%), Gaps = 20/838 (2%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPR +SE+ P+P+AS+ FI S N FR+ C+ +VN + FTN +LF IL+SS L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP+Q S RN IL DY FTS+FT+EI LK+ +G HKGSFCRN FN+LD+LVV
Sbjct: 918 AAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVV 977
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
+VSL SF +++ A++ AINRAKGLKHVVQCV VA++TIGNI++VT
Sbjct: 978 SVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 1037
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG + C+D SK TEAEC+G YI Y+DG+ P+ + R W N+ F+
Sbjct: 1038 LLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFD 1097
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP+LLY +IDS+ EDKGPI+N R +++
Sbjct: 1098 FDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFM 1157
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N+ QY+VW+ V
Sbjct: 1158 MNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVN 1217
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S F+ +++ N++FTG+F E +LK++A PK+
Sbjct: 1218 STYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKH 1277
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGGTNL-ISINFFRLFRVMRLVKLLSRGEGIRT 3702
Y D WN FD L+VVGS +DI ++N N ISI FFRLFRVMRLVKLLSRGEGIRT
Sbjct: 1278 YFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEGIRT 1337
Query: 3703 LLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILV 3882
LLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL+D+T I+RNNNF +FP A+L+
Sbjct: 1338 LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLL 1397
Query: 3883 LFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSF 4062
LFR ATGEAWQDIML+C + +C P S+ + E+ CG++FA YFISF+MLC+F
Sbjct: 1398 LFRCATGEAWQDIMLACMPGK--KCAPESEPSNSTE-GETPCGSSFAVFYFISFYMLCAF 1454
Query: 4063 LVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKIS 4242
L+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+W+EYDP+AKGRIKHLDVVTLLR+I
Sbjct: 1455 LIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQ 1514
Query: 4243 PPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTE---------- 4392
PPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFALVRT L+I TE
Sbjct: 1515 PPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEEGPSPSEAHQ 1574
Query: 4393 ---------GNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQ 4545
GN+++ANE+LR+ IK+IWKRT LLD+VVPPAG +D+VTVGKFYATFLIQ
Sbjct: 1575 GAEDPFRPAGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQ 1633
Query: 4546 DYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDE 4719
+YFR+FKKRKE G P+Q A++LQAGLRTLH+IGPE++RAISG+L + D+
Sbjct: 1634 EYFRKFKKRKEQGLVG-KPSQR-NALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDK 1689
Score = 722 bits (1863), Expect = 0.0
Identities = 383/698 (54%), Positives = 459/698 (64%), Gaps = 28/698 (4%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXX-XXXNNPIRKLCISIVEWKPFEFLILFMICANCIA 312
+KR KP +Q + NPIR+ CISIVEWKPFE +IL I ANC+A
Sbjct: 81 RKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVA 140
Query: 313 LAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDF 492
LAIY P+P DS+ N+ LE +EY+F+++FT+E LK++A G +FHP+AYLRN WN+LDF
Sbjct: 141 LAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDF 200
Query: 493 IIVVIGLVSTILSKMSIQ-----------GFDVKALRAFRVLRPLRLVSGVPSLQVVLNA 639
IIVV+GL S IL + + GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+
Sbjct: 201 IIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNS 260
Query: 640 ILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPA--TGQLAQKDPTPCGTDT 813
I++AM+PLLHIALLVLFVI+IYAIIGLELF GK+H TC + A+ DP+PC +T
Sbjct: 261 IIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALET 320
Query: 814 EGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDV 993
G +CQ + ++ G W GP +GITNFDNF AMLTVFQC+++EGWTDV
Sbjct: 321 -GHGRQCQ-NGTVCKPG----------WDGPKHGITNFDNFAFAMLTVFQCITMEGWTDV 368
Query: 994 MYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQ 1173
+YWVNDAVGR+WPWIYFVTL+I+GSFFVLNLVLGVLSGEFSKEREKA+ARG FQK REKQ
Sbjct: 369 LYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 428
Query: 1174 QLEEDLKGYLDWITQAEDIEPVNEDEQEDE--------PVAQTXXXXXXXXXXXXXXXXX 1329
QLEEDLKGYLDWITQAEDI+P NEDE DE P ++T
Sbjct: 429 QLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGEN 488
Query: 1330 XPSKWAARMKRLE------KLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQ 1491
++ A R+ + + + N VKS FYW SEHY Q
Sbjct: 489 CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQ 548
Query: 1492 SEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYF 1671
WL Q AN + LF+ EMLLKMYSLG Y S FNRFDCFVV ILE +LV
Sbjct: 549 PNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+M PLG+SVLR RLLRIFK+T+YW
Sbjct: 609 KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668
Query: 1852 GMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGV 2031
GMQ+FGGKFNF+ Q + R+ FD F Q+LLTVFQILTGEDWN+VMY GI ++GG G+
Sbjct: 669 GMQLFGGKFNFDEMQTR-RSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGM 727
Query: 2032 IVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNA 2145
+VCIY+I+LFICGNYILLNVFLAIAVDNLADA+SLT+A
Sbjct: 728 LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSA 765
Score = 131 bits (329), Expect = 2e-28
Identities = 100/342 (29%), Positives = 162/342 (47%), Gaps = 10/342 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V NN R C IV F LILF I + I+L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P Q + ++N +L +YVF +FT+E +LK+ A G H ++ RN +NILD +
Sbjct: 918 AAEDP--VQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLL 975
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S + +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 976 VVSVSLISFGIQSSAINV--VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIV 1033
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ-KDPTPCGTDTEGSAFKCQPSDSL 852
++ + ++A IG++LF GKL+ TC D + A+ K D E QP
Sbjct: 1034 IVTTLLQFMFACIGVQLFKGKLY-TCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRS-- 1090
Query: 853 TNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWP 1032
WE N +FDN AM+ +F + EGW +++Y D+ +
Sbjct: 1091 ------WE-----------NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKG 1133
Query: 1033 WIY---------FVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
IY F+ +I+ +FF++N+ +G + F ++ E+
Sbjct: 1134 PIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1175
Score = 95.9 bits (237), Expect = 1e-17
Identities = 64/259 (24%), Positives = 124/259 (47%), Gaps = 5/259 (1%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S F +++ ++ +NT+++A +HY + D N +F E +LK+ +L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD VV G ++ + + + I+ R R++R+ K+ +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL--VETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + + S +++ + LL+ L I++++GMQ F GK D+ + R + F +FP ++
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT--RRSTFDNFPQSL 696
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNF----AYPYFISF 4044
L +F+ TGE W +M D G G +F YFI
Sbjct: 697 LTVFQILTGEDWNSVMY--------------DGIMAYG------GPSFPGMLVCIYFIIL 736
Query: 4045 FMLCSFLVINLFVAVIMDN 4101
F+ +++++N+F+A+ +DN
Sbjct: 737 FICGNYILLNVFLAIAVDN 755
Score = 90.9 bits (224), Expect = 3e-16
Identities = 88/353 (24%), Positives = 148/353 (40%), Gaps = 54/353 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE +I L I N V+LA +P S L+ +F +F EA LK++A
Sbjct: 124 KPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGL 183
Query: 3511 -LNPKNYISDRWNVFD-LLVVVGSFIDITYGKLNPGGTNLIS-------INFFRLFRVMR 3663
+P Y+ + WN+ D ++VVVG F I G N + + R FRV+R
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLR 243
Query: 3664 LVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV--------- 3813
++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F GK+
Sbjct: 244 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEG 303
Query: 3814 -----ALDDSTSI------------------------HRNNNFHSFPAAILVLFRSATGE 3906
A DD + H NF +F A+L +F+ T E
Sbjct: 304 IADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITME 363
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVA 4086
W D++ +D G ++ + YF++ ++ SF V+NL +
Sbjct: 364 GWTDVLYWVND---------------------AVGRDWPWIYFVTLIIIGSFFVLNLVLG 402
Query: 4087 VIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
V+ F G + +R + + D KG +LD +T I P
Sbjct: 403 VLSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 449
Score = 89.0 bits (219), Expect = 1e-15
Identities = 77/282 (27%), Positives = 122/282 (42%), Gaps = 29/282 (10%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR--NMILNYF 2502
+L L+ N R C +V F +L I + LA P + + N L
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL----RTDAMS 2670
+Y F +FTVE LKVI +GL+FH ++ RN +NLLD ++V V L S +L + D +
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 2671 XXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
A ++ L+ V+ +I A+ + +I L+ + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 2824 AIIGVQLFKGTFF-LCNDLSKMTE-------AECRGEYIH---YEDGDPTKPVSKKRVW- 2967
AIIG++LF G C + + + + C E H ++G KP W
Sbjct: 283 AIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKP-----GWD 337
Query: 2968 --SNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEED 3087
+ NFDN AM+++F T EGW +LY D+ D
Sbjct: 338 GPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRD 379
Score = 87.0 bits (214), Expect = 5e-15
Identities = 73/304 (24%), Positives = 130/304 (42%), Gaps = 22/304 (7%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+L+ +I N I LA+ Q Y Q +K + + +F +FT+E +LK++A F
Sbjct: 1221 FEYLMFVLILLNTICLAM-QHY-GQSCLFK-IAMNILNMLFTGLFTVEMILKLIA----F 1273
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMSI----QGFDVKALRAFRVLRPLRLVSGVP 615
P Y +AWN D +IVV +V +++++ + R FRV+R ++L+S
Sbjct: 1274 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGE 1333
Query: 616 SLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPT 795
++ +L +++ L ++ALL++ + IYA+IG+++F G++A D T
Sbjct: 1334 GIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-------------GKIALNDTT 1380
Query: 796 PCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSL 975
N NF F A+L +F+C +
Sbjct: 1381 EI------------------------------------NRNNNFQTFPQAVLLLFRCATG 1404
Query: 976 EGWTDVMYWV------------------NDAVGREWPWIYFVTLVILGSFFVLNLVLGVL 1101
E W D+M G + YF++ +L +F ++NL + V+
Sbjct: 1405 EAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVI 1464
Query: 1102 SGEF 1113
F
Sbjct: 1465 MDNF 1468
Score = 74.3 bits (181), Expect = 3e-11
Identities = 55/229 (24%), Positives = 96/229 (41%), Gaps = 16/229 (6%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HYGQS + N+ F LF++EM+LK+ + Y +N FD +V+ SI++
Sbjct: 1239 QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDI 1298
Query: 1657 VLVYFDLMKP---LGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXX 1827
+ + + + ++ R R++R+ K+
Sbjct: 1299 AITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVM 1358
Query: 1828 XXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGI--- 1998
GMQVFG + + NF TF QA+L +F+ TGE W +M +
Sbjct: 1359 LFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGK 1418
Query: 1999 ----ESFGGVGTLGVIVC------IYYIVLFICGNYILLNVFLAIAVDN 2115
ES T G C Y+I ++ ++++N+F+A+ +DN
Sbjct: 1419 KCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDN 1467
Score = 43.1 bits (100), Expect = 0.077
Identities = 47/240 (19%), Positives = 88/240 (36%), Gaps = 38/240 (15%)
Frame = +1
Query: 1504 DHFQTMANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYF 1671
+H A+ F +F++E++LKM + G ++ + FN D VV S++ F +
Sbjct: 930 NHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS 989
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+ V +LR R+LR +
Sbjct: 990 AINV---VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACI 1046
Query: 1852 GMQVFGGKFNFNPQQPK------------------------PRA------NFDTFVQALL 1941
G+Q+F GK K PR+ +FD + A++
Sbjct: 1047 GVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMM 1106
Query: 1942 TVFQILTGEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+F + T E W ++Y I+S G + V + I++I+ I + ++N+F+ +
Sbjct: 1107 ALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1166
>gi|508197|emb|CAA84342.1| voltage-dependent L-type Ca channel alpha 1
subunit [Homo sapiens]
Length = 2157
Score = 1014 bits (2621), Expect = 0.0
Identities = 510/849 (60%), Positives = 640/849 (75%), Gaps = 31/849 (3%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPR +SE+ P+P+AS+ FI S N FR+ C+ +VN + FTN +LF IL+SS L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP+Q S RN IL YFD FT++FT+EI LK+ +G HKGSFCRN FN+LD+LVV
Sbjct: 918 AAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVV 977
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
+VSL SF +++ A++ AINRAKGLKHVVQCV VA++TIGNI++VT
Sbjct: 978 SVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 1037
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG + C+D SK TEAEC+G YI Y+DG+ P+ + R W N+ F+
Sbjct: 1038 LLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFD 1097
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP+LLY +IDS+ EDKGPI+N R +++
Sbjct: 1098 FDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFM 1157
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N+ QY+VW+ V
Sbjct: 1158 MNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVN 1217
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S F+ +++ N++FTG+F E +LK++A PK+
Sbjct: 1218 STYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKH 1277
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGG------------TNLISINFFRLFRVMRLV 3669
Y D WN FD L+VVGS +DI ++NP + ISI FFRLFRVMRLV
Sbjct: 1278 YFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLV 1337
Query: 3670 KLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNN 3849
KLLSRGEGIRTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL+D+T I+RNN
Sbjct: 1338 KLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNN 1397
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FP A+L+LFR ATGEAWQDIML+C + +C P S+ + E+ CG++FA
Sbjct: 1398 NFQTFPQAVLLLFRCATGEAWQDIMLACMPGK--KCAPESEPSNSTE-GETPCGSSFAVF 1454
Query: 4030 YFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKH 4209
YFISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+W+EYDP+AKGRIKH
Sbjct: 1455 YFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKH 1514
Query: 4210 LDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYT 4389
LDVVTLLR+I PPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFALVRT L+I T
Sbjct: 1515 LDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKT 1574
Query: 4390 E-------------------GNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVT 4512
E GN+++ANE+LR+ IK+IWKRT LLD+VVPPAG +D+VT
Sbjct: 1575 EEGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAG-DDEVT 1633
Query: 4513 VGKFYATFLIQDYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGN 4692
VGKFYATFLIQ+YFR+FKKRKE G P+Q A++LQAGLRTLH+IGPE++RAISG+
Sbjct: 1634 VGKFYATFLIQEYFRKFKKRKEQGLVG-KPSQR-NALSLQAGLRTLHDIGPEIRRAISGD 1691
Query: 4693 LETDFNFDE 4719
L + D+
Sbjct: 1692 LTAEEELDK 1700
Score = 722 bits (1863), Expect = 0.0
Identities = 383/698 (54%), Positives = 459/698 (64%), Gaps = 28/698 (4%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXX-XXXNNPIRKLCISIVEWKPFEFLILFMICANCIA 312
+KR KP +Q + NPIR+ CISIVEWKPFE +IL I ANC+A
Sbjct: 81 RKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVA 140
Query: 313 LAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDF 492
LAIY P+P DS+ N+ LE +EY+F+++FT+E LK++A G +FHP+AYLRN WN+LDF
Sbjct: 141 LAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDF 200
Query: 493 IIVVIGLVSTILSKMSIQ-----------GFDVKALRAFRVLRPLRLVSGVPSLQVVLNA 639
IIVV+GL S IL + + GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+
Sbjct: 201 IIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNS 260
Query: 640 ILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPA--TGQLAQKDPTPCGTDT 813
I++AM+PLLHIALLVLFVI+IYAIIGLELF GK+H TC + A+ DP+PC +T
Sbjct: 261 IIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALET 320
Query: 814 EGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDV 993
G +CQ + ++ G W GP +GITNFDNF AMLTVFQC+++EGWTDV
Sbjct: 321 -GHGRQCQ-NGTVCKPG----------WDGPKHGITNFDNFAFAMLTVFQCITMEGWTDV 368
Query: 994 MYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQ 1173
+YWVNDAVGR+WPWIYFVTL+I+GSFFVLNLVLGVLSGEFSKEREKA+ARG FQK REKQ
Sbjct: 369 LYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 428
Query: 1174 QLEEDLKGYLDWITQAEDIEPVNEDEQEDE--------PVAQTXXXXXXXXXXXXXXXXX 1329
QLEEDLKGYLDWITQAEDI+P NEDE DE P ++T
Sbjct: 429 QLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGEN 488
Query: 1330 XPSKWAARMKRLE------KLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQ 1491
++ A R+ + + + N VKS FYW SEHY Q
Sbjct: 489 CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQ 548
Query: 1492 SEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYF 1671
WL Q AN + LF+ EMLLKMYSLG Y S FNRFDCFVV ILE +LV
Sbjct: 549 PNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+M PLG+SVLR RLLRIFK+T+YW
Sbjct: 609 KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668
Query: 1852 GMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGV 2031
GMQ+FGGKFNF+ Q + R+ FD F Q+LLTVFQILTGEDWN+VMY GI ++GG G+
Sbjct: 669 GMQLFGGKFNFDEMQTR-RSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGM 727
Query: 2032 IVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNA 2145
+VCIY+I+LFICGNYILLNVFLAIAVDNLADA+SLT+A
Sbjct: 728 LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSA 765
Score = 127 bits (320), Expect = 2e-27
Identities = 100/342 (29%), Positives = 160/342 (46%), Gaps = 10/342 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V NN R C IV F LILF I + I+L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P Q + ++N +L + VF +FTIE LK+ A G H ++ RN +NILD +
Sbjct: 918 AAEDP--VQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLL 975
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S + +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 976 VVSVSLISFGIQSSAINV--VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIV 1033
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ-KDPTPCGTDTEGSAFKCQPSDSL 852
++ + ++A IG++LF GKL+ TC D + A+ K D E QP
Sbjct: 1034 IVTTLLQFMFACIGVQLFKGKLY-TCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRS-- 1090
Query: 853 TNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWP 1032
WE N +FDN AM+ +F + EGW +++Y D+ +
Sbjct: 1091 ------WE-----------NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKG 1133
Query: 1033 WIY---------FVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
IY F+ +I+ +FF++N+ +G + F ++ E+
Sbjct: 1134 PIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1175
Score = 95.9 bits (237), Expect = 1e-17
Identities = 64/259 (24%), Positives = 124/259 (47%), Gaps = 5/259 (1%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S F +++ ++ +NT+++A +HY + D N +F E +LK+ +L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD VV G ++ + + + I+ R R++R+ K+ +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL--VETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + + S +++ + LL+ L I++++GMQ F GK D+ + R + F +FP ++
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT--RRSTFDNFPQSL 696
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNF----AYPYFISF 4044
L +F+ TGE W +M D G G +F YFI
Sbjct: 697 LTVFQILTGEDWNSVMY--------------DGIMAYG------GPSFPGMLVCIYFIIL 736
Query: 4045 FMLCSFLVINLFVAVIMDN 4101
F+ +++++N+F+A+ +DN
Sbjct: 737 FICGNYILLNVFLAIAVDN 755
Score = 90.9 bits (224), Expect = 3e-16
Identities = 88/353 (24%), Positives = 148/353 (40%), Gaps = 54/353 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE +I L I N V+LA +P S L+ +F +F EA LK++A
Sbjct: 124 KPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGL 183
Query: 3511 -LNPKNYISDRWNVFD-LLVVVGSFIDITYGKLNPGGTNLIS-------INFFRLFRVMR 3663
+P Y+ + WN+ D ++VVVG F I G N + + R FRV+R
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLR 243
Query: 3664 LVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV--------- 3813
++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F GK+
Sbjct: 244 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEG 303
Query: 3814 -----ALDDSTSI------------------------HRNNNFHSFPAAILVLFRSATGE 3906
A DD + H NF +F A+L +F+ T E
Sbjct: 304 IADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITME 363
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVA 4086
W D++ +D G ++ + YF++ ++ SF V+NL +
Sbjct: 364 GWTDVLYWVND---------------------AVGRDWPWIYFVTLIIIGSFFVLNLVLG 402
Query: 4087 VIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
V+ F G + +R + + D KG +LD +T I P
Sbjct: 403 VLSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 449
Score = 89.0 bits (219), Expect = 1e-15
Identities = 77/282 (27%), Positives = 122/282 (42%), Gaps = 29/282 (10%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR--NMILNYF 2502
+L L+ N R C +V F +L I + LA P + + N L
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL----RTDAMS 2670
+Y F +FTVE LKVI +GL+FH ++ RN +NLLD ++V V L S +L + D +
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 2671 XXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
A ++ L+ V+ +I A+ + +I L+ + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 2824 AIIGVQLFKGTFF-LCNDLSKMTE-------AECRGEYIH---YEDGDPTKPVSKKRVW- 2967
AIIG++LF G C + + + + C E H ++G KP W
Sbjct: 283 AIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKP-----GWD 337
Query: 2968 --SNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEED 3087
+ NFDN AM+++F T EGW +LY D+ D
Sbjct: 338 GPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRD 379
Score = 82.8 bits (203), Expect = 9e-14
Identities = 73/315 (23%), Positives = 130/315 (41%), Gaps = 33/315 (10%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+L+ +I N I LA+ Q Y Q +K + + +F +FT+E +LK++A F
Sbjct: 1221 FEYLMFVLILLNTICLAM-QHY-GQSCLFK-IAMNILNMLFTGLFTVEMILKLIA----F 1273
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMSI---------------QGFDVKALRAFRV 582
P Y +AWN D +IVV +V +++++ + R FRV
Sbjct: 1274 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRV 1333
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
+R ++L+S ++ +L +++ L ++ALL++ + IYA+IG+++F
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF----------- 1382
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
G++A D T N NF F
Sbjct: 1383 --GKIALNDTTEI------------------------------------NRNNNFQTFPQ 1404
Query: 943 AMLTVFQCVSLEGWTDVMYWV------------------NDAVGREWPWIYFVTLVILGS 1068
A+L +F+C + E W D+M G + YF++ +L +
Sbjct: 1405 AVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCA 1464
Query: 1069 FFVLNLVLGVLSGEF 1113
F ++NL + V+ F
Sbjct: 1465 FLIINLFVAVIMDNF 1479
Score = 69.7 bits (169), Expect = 8e-10
Identities = 55/240 (22%), Positives = 96/240 (39%), Gaps = 27/240 (11%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HYGQS + N+ F LF++EM+LK+ + Y +N FD +V+ SI++
Sbjct: 1239 QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDI 1298
Query: 1657 VLVYFDLMKP--------------LGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXX 1794
+ + + + ++ R R++R+ K+
Sbjct: 1299 AITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQ 1358
Query: 1795 XXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDW 1974
GMQVFG + + NF TF QA+L +F+ TGE W
Sbjct: 1359 ALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAW 1418
Query: 1975 NTVMYHGI-------ESFGGVGTLGVIVC------IYYIVLFICGNYILLNVFLAIAVDN 2115
+M + ES T G C Y+I ++ ++++N+F+A+ +DN
Sbjct: 1419 QDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDN 1478
Score = 41.2 bits (95), Expect = 0.29
Identities = 46/240 (19%), Positives = 87/240 (36%), Gaps = 38/240 (15%)
Frame = +1
Query: 1504 DHFQTMANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYF 1671
+H ++ F +F++E+ LKM + G ++ + FN D VV S++ F +
Sbjct: 930 NHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS 989
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+ V +LR R+LR +
Sbjct: 990 AINV---VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACI 1046
Query: 1852 GMQVFGGKFNFNPQQPK------------------------PRA------NFDTFVQALL 1941
G+Q+F GK K PR+ +FD + A++
Sbjct: 1047 GVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMM 1106
Query: 1942 TVFQILTGEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+F + T E W ++Y I+S G + V + I++I+ I + ++N+F+ +
Sbjct: 1107 ALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1166
>gi|1729771|emb|CAA99284.1| voltage-dependent L-type calcium channel
alpha 1C subunit [Homo sapiens]
Length = 2157
Score = 1011 bits (2615), Expect = 0.0
Identities = 510/849 (60%), Positives = 639/849 (75%), Gaps = 31/849 (3%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPR +SE+ P+P+AS+ FI S N FR+ C+ +VN + FTN +LF IL+SS L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP+Q S RN IL DY FTS+FT+EI LK+ +G HKGSFCRN FN+LD+LVV
Sbjct: 918 AAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVV 977
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
+VSL SF +++ A++ AINRAKGLKHVVQCV VA++TIGNI++VT
Sbjct: 978 SVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 1037
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG + C+D SK TEAEC+G YI Y+DG+ P+ + R W N+ F+
Sbjct: 1038 LLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFD 1097
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP+LLY +IDS+ EDKGPI+N R +++
Sbjct: 1098 FDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFM 1157
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N+ QY+VW+ V
Sbjct: 1158 MNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVN 1217
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S F+ +++ N++FTG+F E +LK++A PK+
Sbjct: 1218 STYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKH 1277
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGG------------TNLISINFFRLFRVMRLV 3669
Y D WN FD L+VVGS +DI ++NP + ISI FFRLFRVMRLV
Sbjct: 1278 YFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLV 1337
Query: 3670 KLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNN 3849
KLLSRGEGIRTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL+D+T I+RNN
Sbjct: 1338 KLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNN 1397
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FP A+L+LFR ATGEAWQDIML+C + +C P S+ + E+ CG++FA
Sbjct: 1398 NFQTFPQAVLLLFRCATGEAWQDIMLACMPGK--KCAPESEPSNSTE-GETPCGSSFAVF 1454
Query: 4030 YFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKH 4209
YFISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+W+EYDP+AKGRIKH
Sbjct: 1455 YFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKH 1514
Query: 4210 LDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYT 4389
LDVVTLLR+I PPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFALVRT L+I T
Sbjct: 1515 LDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKT 1574
Query: 4390 E-------------------GNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVT 4512
E GN+++ANE+LR+ IK+IWKRT LLD+VVPPAG +D+VT
Sbjct: 1575 EEGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAG-DDEVT 1633
Query: 4513 VGKFYATFLIQDYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGN 4692
VGKFYATFLIQ+YFR+FKKRKE G P+Q A++LQAGLRTLH+IGPE++RAISG+
Sbjct: 1634 VGKFYATFLIQEYFRKFKKRKEQGLVG-KPSQR-NALSLQAGLRTLHDIGPEIRRAISGD 1691
Query: 4693 LETDFNFDE 4719
L + D+
Sbjct: 1692 LTAEEELDK 1700
Score = 722 bits (1863), Expect = 0.0
Identities = 383/698 (54%), Positives = 459/698 (64%), Gaps = 28/698 (4%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXX-XXXNNPIRKLCISIVEWKPFEFLILFMICANCIA 312
+KR KP +Q + NPIR+ CISIVEWKPFE +IL I ANC+A
Sbjct: 81 RKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVA 140
Query: 313 LAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDF 492
LAIY P+P DS+ N+ LE +EY+F+++FT+E LK++A G +FHP+AYLRN WN+LDF
Sbjct: 141 LAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDF 200
Query: 493 IIVVIGLVSTILSKMSIQ-----------GFDVKALRAFRVLRPLRLVSGVPSLQVVLNA 639
IIVV+GL S IL + + GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+
Sbjct: 201 IIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNS 260
Query: 640 ILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPA--TGQLAQKDPTPCGTDT 813
I++AM+PLLHIALLVLFVI+IYAIIGLELF GK+H TC + A+ DP+PC +T
Sbjct: 261 IIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALET 320
Query: 814 EGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDV 993
G +CQ + ++ G W GP +GITNFDNF AMLTVFQC+++EGWTDV
Sbjct: 321 -GHGRQCQ-NGTVCKPG----------WDGPKHGITNFDNFAFAMLTVFQCITMEGWTDV 368
Query: 994 MYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQ 1173
+YWVNDAVGR+WPWIYFVTL+I+GSFFVLNLVLGVLSGEFSKEREKA+ARG FQK REKQ
Sbjct: 369 LYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 428
Query: 1174 QLEEDLKGYLDWITQAEDIEPVNEDEQEDE--------PVAQTXXXXXXXXXXXXXXXXX 1329
QLEEDLKGYLDWITQAEDI+P NEDE DE P ++T
Sbjct: 429 QLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGEN 488
Query: 1330 XPSKWAARMKRLE------KLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQ 1491
++ A R+ + + + N VKS FYW SEHY Q
Sbjct: 489 CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQ 548
Query: 1492 SEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYF 1671
WL Q AN + LF+ EMLLKMYSLG Y S FNRFDCFVV ILE +LV
Sbjct: 549 PNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+M PLG+SVLR RLLRIFK+T+YW
Sbjct: 609 KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668
Query: 1852 GMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGV 2031
GMQ+FGGKFNF+ Q + R+ FD F Q+LLTVFQILTGEDWN+VMY GI ++GG G+
Sbjct: 669 GMQLFGGKFNFDEMQTR-RSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGM 727
Query: 2032 IVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNA 2145
+VCIY+I+LFICGNYILLNVFLAIAVDNLADA+SLT+A
Sbjct: 728 LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSA 765
Score = 131 bits (329), Expect = 2e-28
Identities = 100/342 (29%), Positives = 162/342 (47%), Gaps = 10/342 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V NN R C IV F LILF I + I+L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P Q + ++N +L +YVF +FT+E +LK+ A G H ++ RN +NILD +
Sbjct: 918 AAEDP--VQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLL 975
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S + +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 976 VVSVSLISFGIQSSAINV--VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIV 1033
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ-KDPTPCGTDTEGSAFKCQPSDSL 852
++ + ++A IG++LF GKL+ TC D + A+ K D E QP
Sbjct: 1034 IVTTLLQFMFACIGVQLFKGKLY-TCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRS-- 1090
Query: 853 TNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWP 1032
WE N +FDN AM+ +F + EGW +++Y D+ +
Sbjct: 1091 ------WE-----------NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKG 1133
Query: 1033 WIY---------FVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
IY F+ +I+ +FF++N+ +G + F ++ E+
Sbjct: 1134 PIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1175
Score = 95.9 bits (237), Expect = 1e-17
Identities = 64/259 (24%), Positives = 124/259 (47%), Gaps = 5/259 (1%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S F +++ ++ +NT+++A +HY + D N +F E +LK+ +L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD VV G ++ + + + I+ R R++R+ K+ +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL--VETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + + S +++ + LL+ L I++++GMQ F GK D+ + R + F +FP ++
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT--RRSTFDNFPQSL 696
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNF----AYPYFISF 4044
L +F+ TGE W +M D G G +F YFI
Sbjct: 697 LTVFQILTGEDWNSVMY--------------DGIMAYG------GPSFPGMLVCIYFIIL 736
Query: 4045 FMLCSFLVINLFVAVIMDN 4101
F+ +++++N+F+A+ +DN
Sbjct: 737 FICGNYILLNVFLAIAVDN 755
Score = 90.9 bits (224), Expect = 3e-16
Identities = 88/353 (24%), Positives = 148/353 (40%), Gaps = 54/353 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE +I L I N V+LA +P S L+ +F +F EA LK++A
Sbjct: 124 KPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGL 183
Query: 3511 -LNPKNYISDRWNVFD-LLVVVGSFIDITYGKLNPGGTNLIS-------INFFRLFRVMR 3663
+P Y+ + WN+ D ++VVVG F I G N + + R FRV+R
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLR 243
Query: 3664 LVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV--------- 3813
++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F GK+
Sbjct: 244 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEG 303
Query: 3814 -----ALDDSTSI------------------------HRNNNFHSFPAAILVLFRSATGE 3906
A DD + H NF +F A+L +F+ T E
Sbjct: 304 IADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITME 363
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVA 4086
W D++ +D G ++ + YF++ ++ SF V+NL +
Sbjct: 364 GWTDVLYWVND---------------------AVGRDWPWIYFVTLIIIGSFFVLNLVLG 402
Query: 4087 VIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
V+ F G + +R + + D KG +LD +T I P
Sbjct: 403 VLSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 449
Score = 89.0 bits (219), Expect = 1e-15
Identities = 77/282 (27%), Positives = 122/282 (42%), Gaps = 29/282 (10%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR--NMILNYF 2502
+L L+ N R C +V F +L I + LA P + + N L
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL----RTDAMS 2670
+Y F +FTVE LKVI +GL+FH ++ RN +NLLD ++V V L S +L + D +
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 2671 XXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
A ++ L+ V+ +I A+ + +I L+ + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 2824 AIIGVQLFKGTFF-LCNDLSKMTE-------AECRGEYIH---YEDGDPTKPVSKKRVW- 2967
AIIG++LF G C + + + + C E H ++G KP W
Sbjct: 283 AIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKP-----GWD 337
Query: 2968 --SNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEED 3087
+ NFDN AM+++F T EGW +LY D+ D
Sbjct: 338 GPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRD 379
Score = 82.8 bits (203), Expect = 9e-14
Identities = 73/315 (23%), Positives = 130/315 (41%), Gaps = 33/315 (10%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+L+ +I N I LA+ Q Y Q +K + + +F +FT+E +LK++A F
Sbjct: 1221 FEYLMFVLILLNTICLAM-QHY-GQSCLFK-IAMNILNMLFTGLFTVEMILKLIA----F 1273
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMSI---------------QGFDVKALRAFRV 582
P Y +AWN D +IVV +V +++++ + R FRV
Sbjct: 1274 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRV 1333
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
+R ++L+S ++ +L +++ L ++ALL++ + IYA+IG+++F
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF----------- 1382
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
G++A D T N NF F
Sbjct: 1383 --GKIALNDTTEI------------------------------------NRNNNFQTFPQ 1404
Query: 943 AMLTVFQCVSLEGWTDVMYWV------------------NDAVGREWPWIYFVTLVILGS 1068
A+L +F+C + E W D+M G + YF++ +L +
Sbjct: 1405 AVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCA 1464
Query: 1069 FFVLNLVLGVLSGEF 1113
F ++NL + V+ F
Sbjct: 1465 FLIINLFVAVIMDNF 1479
Score = 69.7 bits (169), Expect = 8e-10
Identities = 55/240 (22%), Positives = 96/240 (39%), Gaps = 27/240 (11%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HYGQS + N+ F LF++EM+LK+ + Y +N FD +V+ SI++
Sbjct: 1239 QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDI 1298
Query: 1657 VLVYFDLMKP--------------LGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXX 1794
+ + + + ++ R R++R+ K+
Sbjct: 1299 AITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQ 1358
Query: 1795 XXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDW 1974
GMQVFG + + NF TF QA+L +F+ TGE W
Sbjct: 1359 ALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAW 1418
Query: 1975 NTVMYHGI-------ESFGGVGTLGVIVC------IYYIVLFICGNYILLNVFLAIAVDN 2115
+M + ES T G C Y+I ++ ++++N+F+A+ +DN
Sbjct: 1419 QDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDN 1478
Score = 43.1 bits (100), Expect = 0.077
Identities = 47/240 (19%), Positives = 88/240 (36%), Gaps = 38/240 (15%)
Frame = +1
Query: 1504 DHFQTMANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYF 1671
+H A+ F +F++E++LKM + G ++ + FN D VV S++ F +
Sbjct: 930 NHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS 989
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+ V +LR R+LR +
Sbjct: 990 AINV---VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACI 1046
Query: 1852 GMQVFGGKFNFNPQQPK------------------------PRA------NFDTFVQALL 1941
G+Q+F GK K PR+ +FD + A++
Sbjct: 1047 GVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMM 1106
Query: 1942 TVFQILTGEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+F + T E W ++Y I+S G + V + I++I+ I + ++N+F+ +
Sbjct: 1107 ALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1166
>gi|29789032|ref|NP_036649.1| calcium channel, voltage-dependent,
alpha 1C subunit; Ca channel, voltage-dependent, L type,
alpha 1c subunit; RATIVS302; Ca channel voltage-dependent
L type alpha 1c subunit [Rattus norvegicus]
gi|116412|sp|P22002|CCAC_RAT Voltage-dependent L-type calcium channel
alpha-1C subunit (Voltage-gated calcium channel alpha
subunit Cav1.2) (Calcium channel, L type, alpha-1
polypeptide, isoform 1, cardiac muscle) (RAT brain class
C) (RBC)
gi|207647|gb|AAA85463.1| dihydropryridine-sensitive calcium channel
alpha-1 subunit
Length = 2169
Score = 1008 bits (2605), Expect = 0.0
Identities = 505/830 (60%), Positives = 636/830 (75%), Gaps = 12/830 (1%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPR +SE+ P+P+AS+ FI S N FR+ C+ +VN + FTN +LF IL+SS L
Sbjct: 888 RPRPLSELHLKEKAVPMPEASAFFIFSPNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 947
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP+Q S RN IL YFD FT++FT+EI LK+ +G HKGSFCRN FN+LD+LVV
Sbjct: 948 AAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVV 1007
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
+VSL SF +++ A++ INRAKGLKHVVQCV VA++TIGNI++VT
Sbjct: 1008 SVSLISFGIQSSAINVVKILRVLRVLRPLR-INRAKGLKHVVQCVFVAIRTIGNIVIVTT 1066
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG + C+D SK TEAE +G YI Y+ G+ P+ + R W N+ F+
Sbjct: 1067 LLQFMFACIGVQLFKGKLYTCSDSSKQTEAESKGNYITYKTGEVDHPIIQPRSWENSKFD 1126
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP+LLY +IDS+ EDKGPI+N R +++
Sbjct: 1127 FDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFM 1186
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RYIP+N+ QY+VW+ V
Sbjct: 1187 MNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLPRYIPKNQHQYKVWYVVN 1246
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S F+ +++ N++FTG+F E +LK++A PK+
Sbjct: 1247 STYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKH 1306
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGG------------TNLISINFFRLFRVMRLV 3669
Y D WN FD L+VVGS +DI +++P + ISI FFRLFRVMRLV
Sbjct: 1307 YFCDAWNTFDALIVVGSIVDIAITEVHPAEHTQCSPSMSAEENSRISITFFRLFRVMRLV 1366
Query: 3670 KLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNN 3849
KLLSRGEGIRTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL+D+T I+RNN
Sbjct: 1367 KLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNN 1426
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FP A+L+LFR ATGEAWQDIML+C + +C P S+ + E+ CG++FA
Sbjct: 1427 NFQTFPQAVLLLFRCATGEAWQDIMLACMPGK--KCAPESEPSNSTE-GETPCGSSFAVF 1483
Query: 4030 YFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKH 4209
YFISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+W+EYDP+AKGRIKH
Sbjct: 1484 YFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKH 1543
Query: 4210 LDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYT 4389
LDVVTLLR+I PPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFALVRT L+I T
Sbjct: 1544 LDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKT 1603
Query: 4390 EGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKK 4569
EGN+++ANE+LR+ IK+IWKRT LLD+VVPPAG +D+VTVGKFYATFLIQ+YFR+FKK
Sbjct: 1604 EGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQEYFRKFKK 1662
Query: 4570 RKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDE 4719
RKE G P+Q A++LQAGLRTLH+IGPE++RAISG+L + D+
Sbjct: 1663 RKEQGLVG-KPSQR-NALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDK 1710
Score = 696 bits (1795), Expect = 0.0
Identities = 367/668 (54%), Positives = 444/668 (65%), Gaps = 27/668 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR+ CISIVEWKPFE +IL I ANC+ALAIY P+P DS+ N+ LE +EY+F+++F
Sbjct: 141 NPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIF 200
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQ-----------G 549
T+E LK++A G +FHP+AYLRN WN+LDFIIVV+GL S IL + + G
Sbjct: 201 TVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAG 260
Query: 550 FDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELF 729
FDVKALRAFRVLRPLRLVSGVPSLQVVLN+I++AM+PLLHIALLVLFVI+IYAIIGLELF
Sbjct: 261 FDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELF 320
Query: 730 CGKLHSTCIDPA--TGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPG 903
GK+H TC + A++DP+PC +T G +CQ + ++ G W G
Sbjct: 321 MGKMHKTCYNQEGIIDVPAEEDPSPCALET-GHGRQCQ-NGTVCKPG----------WDG 368
Query: 904 PNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLN 1083
P +GITNFDNF AMLTVFQC+++EGWTDV+YW+ DA+G E PW+YFV+LVI GSFFVLN
Sbjct: 369 PKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLN 428
Query: 1084 LVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDE 1263
LVLGVLSGEFSKEREKA+ARG FQK REKQQLEEDLKGYLDWITQAEDI+P NEDE DE
Sbjct: 429 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDE 488
Query: 1264 --------PVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLE------KLNXXXXXXXX 1401
P ++T ++ A R+ + + + N
Sbjct: 489 DKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCR 548
Query: 1402 XLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSL 1581
VKS FYW SEHY Q WL Q AN + LF+ EMLLKMYSL
Sbjct: 549 AAVKSNVFYWLVIFLVFLNTLTIASEHYNQPHWLTEVQDTANKALLALFTAEMLLKMYSL 608
Query: 1582 GFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXX 1761
G Y S FNRFDCF+V ILE +LV +M PLG+S R RLLRIFK+T+YW
Sbjct: 609 GLQAYFVSLFNRFDCFIVCGGILETILVETKIMSPLGISCWRCVRLLRIFKITRYWNSLS 668
Query: 1762 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALL 1941
GMQ+FGGKFNF+ Q + R+ FD F Q+LL
Sbjct: 669 NLVASLLNSLRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTR-RSTFDNFPQSLL 727
Query: 1942 TVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLA 2121
TVFQILTGEDWN+VMY GI ++GG G++VCIY+I+LFI NYILLN+FLAIAVDNLA
Sbjct: 728 TVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFISPNYILLNLFLAIAVDNLA 787
Query: 2122 DADSLTNA 2145
DA+SLT+A
Sbjct: 788 DAESLTSA 795
Score = 123 bits (309), Expect = 4e-26
Identities = 97/341 (28%), Positives = 157/341 (45%), Gaps = 9/341 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V NN R C IV F LILF I + I+L
Sbjct: 888 RPRPLSELHLKEKAVPMPEASAFFIFSPNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 947
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P Q + ++N +L + VF +FTIE LK+ A G H ++ RN +NILD +
Sbjct: 948 AAEDP--VQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLL 1005
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S + +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 1006 VVSVSLISFGIQSSAIN--VVKILRVLRVLRPLR-INRAKGLKHVVQCVFVAIRTIGNIV 1062
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLT 855
++ + ++A IG++LF GKL+ TC D T + +K D
Sbjct: 1063 IVTTLLQFMFACIGVQLFKGKLY-TCSD-------SSKQTEAESKGNYITYKTGEVDHPI 1114
Query: 856 NMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPW 1035
WE N +FDN AM+ +F + EGW +++Y D+ +
Sbjct: 1115 IQPRSWE-----------NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGP 1163
Query: 1036 IY---------FVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
IY F+ +I+ +FF++N+ +G + F ++ E+
Sbjct: 1164 IYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1204
Score = 96.7 bits (239), Expect = 6e-18
Identities = 64/259 (24%), Positives = 125/259 (47%), Gaps = 5/259 (1%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S F +++ ++ +NT+++A +HY + D N +F E +LK+ +L
Sbjct: 551 VKSNVFYWLVIFLVFLNTLTIASEHYNQPHWLTEVQDTANKALLALFTAEMLLKMYSLGL 610
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD +V G ++ + + + I+ +R R++R+ K+ +
Sbjct: 611 QAYFVSLFNRFDCFIVCGGILETIL--VETKIMSPLGISCWRCVRLLRIFKITRYWNSLS 668
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + + S +++ + LL+ L I++++GMQ F GK D+ + R + F +FP ++
Sbjct: 669 NLVASLLNSLRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT--RRSTFDNFPQSL 726
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNF----AYPYFISF 4044
L +F+ TGE W +M D G G +F YFI
Sbjct: 727 LTVFQILTGEDWNSVMY--------------DGIMAYG------GPSFPGMLVCIYFIIL 766
Query: 4045 FMLCSFLVINLFVAVIMDN 4101
F+ +++++NLF+A+ +DN
Sbjct: 767 FISPNYILLNLFLAIAVDN 785
Score = 87.8 bits (216), Expect = 3e-15
Identities = 88/353 (24%), Positives = 144/353 (39%), Gaps = 54/353 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE +I L I N V+LA +P S L+ +F +F EA LK++A
Sbjct: 154 KPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGL 213
Query: 3511 -LNPKNYISDRWNVFD-LLVVVGSFIDITYGKLNPGGTNLIS-------INFFRLFRVMR 3663
+P Y+ + WN+ D ++VVVG F I G N + + R FRV+R
Sbjct: 214 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLR 273
Query: 3664 LVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV--------- 3813
++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F GK+
Sbjct: 274 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEG 333
Query: 3814 -----ALDDSTSI------------------------HRNNNFHSFPAAILVLFRSATGE 3906
A +D + H NF +F A+L +F+ T E
Sbjct: 334 IIDVPAEEDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITME 393
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVA 4086
W D++ D G + YF+S + SF V+NL +
Sbjct: 394 GWTDVLYWMQD---------------------AMGYELPWVYFVSLVIFGSFFVLNLVLG 432
Query: 4087 VIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
V+ F G + +R + + D KG +LD +T I P
Sbjct: 433 VLSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 479
Score = 87.8 bits (216), Expect = 3e-15
Identities = 74/273 (27%), Positives = 119/273 (43%), Gaps = 29/273 (10%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR--NMILNYF 2502
+L L+ N R C +V F +L I + LA P + + N L
Sbjct: 133 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 192
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL----RTDAMS 2670
+Y F +FTVE LKVI +GL+FH ++ RN +NLLD ++V V L S +L + D +
Sbjct: 193 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 252
Query: 2671 XXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
A ++ L+ V+ +I A+ + +I L+ + ++
Sbjct: 253 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 312
Query: 2824 AIIGVQLFKGTFF--------LCNDLSKMTEAECRGEYIH---YEDGDPTKPVSKKRVW- 2967
AIIG++LF G + + ++ + C E H ++G KP W
Sbjct: 313 AIIGLELFMGKMHKTCYNQEGIIDVPAEEDPSPCALETGHGRQCQNGTVCKP-----GWD 367
Query: 2968 --SNNDFNFDNVGDAMISLFVVSTFEGWPQLLY 3060
+ NFDN AM+++F T EGW +LY
Sbjct: 368 GPKHGITNFDNFAFAMLTVFQCITMEGWTDVLY 400
Score = 82.8 bits (203), Expect = 9e-14
Identities = 75/315 (23%), Positives = 131/315 (40%), Gaps = 33/315 (10%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+L+ +I N I LA+ Q Y Q +K + + +F +FT+E +LK++A F
Sbjct: 1250 FEYLMFVLILLNTICLAM-QHY-GQSCLFK-IAMNILNMLFTGLFTVEMILKLIA----F 1302
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSK------------MSIQG---FDVKALRAFRV 582
P Y +AWN D +IVV +V +++ MS + + R FRV
Sbjct: 1303 KPKHYFCDAWNTFDALIVVGSIVDIAITEVHPAEHTQCSPSMSAEENSRISITFFRLFRV 1362
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
+R ++L+S ++ +L +++ L ++ALL++ + IYA+IG+++F
Sbjct: 1363 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF----------- 1411
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
G++A D T N NF F
Sbjct: 1412 --GKIALNDTTEI------------------------------------NRNNNFQTFPQ 1433
Query: 943 AMLTVFQCVSLEGWTDVMYWV------------------NDAVGREWPWIYFVTLVILGS 1068
A+L +F+C + E W D+M G + YF++ +L +
Sbjct: 1434 AVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCA 1493
Query: 1069 FFVLNLVLGVLSGEF 1113
F ++NL + V+ F
Sbjct: 1494 FLIINLFVAVIMDNF 1508
Score = 69.3 bits (168), Expect = 1e-09
Identities = 55/240 (22%), Positives = 95/240 (38%), Gaps = 27/240 (11%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HYGQS + N+ F LF++EM+LK+ + Y +N FD +V+ SI++
Sbjct: 1268 QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDI 1327
Query: 1657 VLVYF--------------DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXX 1794
+ + + ++ R R++R+ K+
Sbjct: 1328 AITEVHPAEHTQCSPSMSAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQ 1387
Query: 1795 XXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDW 1974
GMQVFG + + NF TF QA+L +F+ TGE W
Sbjct: 1388 ALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAW 1447
Query: 1975 NTVMYHGI-------ESFGGVGTLGVIVC------IYYIVLFICGNYILLNVFLAIAVDN 2115
+M + ES T G C Y+I ++ ++++N+F+A+ +DN
Sbjct: 1448 QDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDN 1507
Score = 64.7 bits (156), Expect = 2e-08
Identities = 76/332 (22%), Positives = 133/332 (39%), Gaps = 12/332 (3%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALA---IYQPYPAQDSDYKNTLLETIEYVF 390
N R+ C + V+ F +L++F++ N + +A QP+ + + +T
Sbjct: 540 NRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPH------WLTEVQDTANKAL 593
Query: 391 IVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG-FDVKAL 567
+ +FT E +LK+ ++G AY + +N D IV G++ TIL + I +
Sbjct: 594 LALFTAEMLLKMYSLGLQ----AYFVSLFNRFDCFIVCGGILETILVETKIMSPLGISCW 649
Query: 568 RAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHS 747
R R+LR ++ SL ++ ++L + L IA L+L + L I L
Sbjct: 650 RCVRLLRIFKITRYWNSLSNLVASLLNS---LRSIASLLLLLFLFIIIFSL--------- 697
Query: 748 TCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNF 927
G G F + + F
Sbjct: 698 -----------------LGMQLFGGKFNFDEMQTRRS---------------------TF 719
Query: 928 DNFGLAMLTVFQCVSLEGWTDVMYWVNDAV----GREWPW----IYFVTLVILGSFFVLN 1083
DNF ++LTVFQ ++ E W VMY D + G +P IYF+ L I ++ +LN
Sbjct: 720 DNFPQSLLTVFQILTGEDWNSVMY---DGIMAYGGPSFPGMLVCIYFIILFISPNYILLN 776
Query: 1084 LVLGVLSGEFSKEREKARARGLFQKFREKQQL 1179
L L + + A+ ++ +E+++L
Sbjct: 777 LFLAIAVDNLADAESLTSAQKEEEEEKERKKL 808
Score = 40.0 bits (92), Expect = 0.65
Identities = 46/240 (19%), Positives = 89/240 (36%), Gaps = 38/240 (15%)
Frame = +1
Query: 1504 DHFQTMANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYF 1671
+H ++ F +F++E+ LKM + G ++ + FN D VV S++ F +
Sbjct: 960 NHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS 1019
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+ V +LR R+LR ++ +
Sbjct: 1020 AINV---VKILRVLRVLRPLRINRA-KGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACI 1075
Query: 1852 GMQVFGGKFNFNPQQPK------------------------PRA------NFDTFVQALL 1941
G+Q+F GK K PR+ +FD + A++
Sbjct: 1076 GVQLFKGKLYTCSDSSKQTEAESKGNYITYKTGEVDHPIIQPRSWENSKFDFDNVLAAMM 1135
Query: 1942 TVFQILTGEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+F + T E W ++Y I+S G + V + I++I+ I + ++N+F+ +
Sbjct: 1136 ALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1195
>gi|33468490|emb|CAE30292.1| L-type dihydropyridine-sensitive calcium
channel alpha-1f subunit [Mus musculus]
Length = 1984
Score = 1008 bits (2605), Expect = 0.0
Identities = 507/838 (60%), Positives = 632/838 (74%), Gaps = 10/838 (1%)
Frame = +1
Query: 2278 MSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAED 2457
+ EV V PIP+ S+ F LS TN R C+ +++H FT+ +L I++SS LAAED
Sbjct: 836 LQEVVPKEKVVPIPEGSAFFCLSQTNPLRKACHTLIHHHIFTSLILVFIILSSVSLAAED 895
Query: 2458 PLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSL 2637
P++A+S RN IL YFDY FTS+FTVEI LK+ VFG H+GSFCR+ FNLLD+LVV+VSL
Sbjct: 896 PIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNLLDLLVVSVSL 955
Query: 2638 TSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQF 2817
SF + + A+S AINRAKGLKHVVQCV VA++TIGNIM+VT +LQF
Sbjct: 956 ISFGIHSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQF 1015
Query: 2818 MFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNV 2997
MFA IGVQLFKG F+ C D +K T EC+G ++ Y DGD ++P+ ++R+W N+DFNFDNV
Sbjct: 1016 MFACIGVQLFKGKFYSCTDEAKHTLKECKGSFLIYPDGDVSRPLVRERLWVNSDFNFDNV 1075
Query: 2998 GDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXX 3177
AM++LF VSTFEGWP LLY AID+N ED+GPI+N +++
Sbjct: 1076 LSAMMALFTVSTFEGWPALLYKAIDANAEDEGPIYNYHVEISVFFIVYIIIIAFFMMNIF 1135
Query: 3178 XGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVTSRAF 3357
GFVI+TF+ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N QYRVW V S AF
Sbjct: 1136 VGFVIITFRAQGEQEYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWATVNSAAF 1195
Query: 3358 EYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISD 3537
EY++FL+I++NTV+LA +HY + F +D+ N++FTG+F E VLKI+A PK+Y +D
Sbjct: 1196 EYLMFLLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFAD 1255
Query: 3538 RWNVFDLLVVVGSFIDITYGKLNPGG--------TNLISINFFRLFRVMRLVKLLSRGEG 3693
WN FD L+VVGS +DI ++N GG ++ ISI FFRLFRVMRLVKLLS+GEG
Sbjct: 1256 AWNTFDALIVVGSVVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLLSKGEG 1315
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAA 3873
IRTLLWTF+KSFQALPYVALLI ++FFIYAVIGMQ FGKVAL D T I+RNNNF +FP A
Sbjct: 1316 IRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQA 1375
Query: 3874 ILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFML 4053
+L+LFR ATGEAWQ+IML+ RCDP SD G E CG++FA YFISFFML
Sbjct: 1376 VLLLFRCATGEAWQEIMLASLPGN--RCDPESDF---GPGEEFTCGSSFAIVYFISFFML 1430
Query: 4054 CSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLR 4233
C+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+WSEYDP AKGRIKHLDVV LLR
Sbjct: 1431 CAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLR 1490
Query: 4234 KISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNIDEAN 4413
+I PPLGFGKLCPHR+ACKRLV+MN+PLNSDGTV FNATLFALVRT+LKI TEGN+D+AN
Sbjct: 1491 RIQPPLGFGKLCPHRVACKRLVAMNVPLNSDGTVTFNATLFALVRTSLKIKTEGNLDQAN 1550
Query: 4414 EQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEMEAKG 4593
++LR IK+IWKR + LLDEV+PP E++VTVGKFYATFLIQDYFR+F++RKE KG
Sbjct: 1551 QELRMVIKKIWKRIKQKLLDEVIPPP-DEEEVTVGKFYATFLIQDYFRKFRRRKE---KG 1606
Query: 4594 VL--PAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDEPEPQHRRPHSLFNN 4761
+L A T + ALQAGLR+L ++GPE+++A++ + E + +E Q NN
Sbjct: 1607 LLGREAPTSTSSALQAGLRSLQDLGPEIRQALTYDTEEEEEEEEAVGQEAEEEEAENN 1664
Score = 449 bits (1154), Expect = e-124
Identities = 223/349 (63%), Positives = 270/349 (76%), Gaps = 12/349 (3%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR+ CISIVEWKPF+ LIL I ANC+AL +Y P+P DS+ N LE +EYVF+V+F
Sbjct: 79 NPIRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIF 138
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQ------------ 546
T+E VLKIVA G + HPSAY+RN WN+LDFIIVV+GL S +L + +
Sbjct: 139 TVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPG 198
Query: 547 GFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLEL 726
GFDVKALRAFRVLRPLRLVSGVPSL +VLN+I++A++PLLHIALLVLFVI+IYAIIGLEL
Sbjct: 199 GFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLEL 258
Query: 727 FCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGP 906
F G++H TC + A++DP+PC + GS C + + EC WPGP
Sbjct: 259 FLGRMHKTCYFLGSDMEAEEDPSPCASS--GSGRSCTLNHT--------ECRGR--WPGP 306
Query: 907 NNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNL 1086
N GITNFDNF AMLTVFQC+++EGWTDV+YW+ DA+G E PW+YFV+LVI GSFFVLNL
Sbjct: 307 NGGITNFDNFFFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNL 366
Query: 1087 VLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIE 1233
VLGVLSGEFSKEREKA+ARG FQK REKQQ+EEDL+GYLDWITQAE+++
Sbjct: 367 VLGVLSGEFSKEREKAKARGDFQKLREKQQMEEDLRGYLDWITQAEELD 415
Score = 241 bits (615), Expect = 1e-61
Identities = 127/244 (52%), Positives = 148/244 (60%)
Frame = +1
Query: 1408 VKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGF 1587
VKS YW SEH+GQ WL Q AN + LF++EMLLK+Y LG
Sbjct: 526 VKSNACYWAVLLLVFLNTLTIASEHHGQPLWLTQTQEYANKVLLCLFTVEMLLKLYGLGP 585
Query: 1588 TTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXX 1767
+ Y S FNRFDCFVV ILE LV M+PLG+SVLR RLLRIFKVT++W
Sbjct: 586 SVYVASFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASLSNL 645
Query: 1768 XXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTV 1947
GMQ+FGGKFNF+ K R+ FDTF QALLTV
Sbjct: 646 VASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTK-RSTFDTFPQALLTV 704
Query: 1948 FQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADA 2127
FQILTGEDWN VMY GI ++GG G++VC+Y+I+LFICGNYILLNVFLAIAVDNLA
Sbjct: 705 FQILTGEDWNVVMYDGIMAYGGPFFPGMLVCVYFIILFICGNYILLNVFLAIAVDNLASG 764
Query: 2128 DSLT 2139
D+ T
Sbjct: 765 DAGT 768
Score = 170 bits (431), Expect = 3e-40
Identities = 157/664 (23%), Positives = 280/664 (41%), Gaps = 33/664 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+RK C +++ F LIL I + ++LA P A ++N +L +Y F +F
Sbjct: 861 NPLRKACHTLIHHHIFTSLILVFIILSSVSLAAEDPIRAHS--FRNHILGYFDYAFTSIF 918
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
T+E +LK+ G H ++ R+ +N+LD ++V + L+S + +I VK LR RV
Sbjct: 919 TVEILLKMTVFGAFLHRGSFCRSWFNLLDLLVVSVSLISFGIHSSAIS--VVKILRVLRV 976
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLR ++ L+ V+ + A+ + +I ++ + ++A IG++LF GK +S C D
Sbjct: 977 LRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYS-CTDE 1035
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
A L + +GS F P ++ VR N+ + NFDN
Sbjct: 1036 AKHTL---------KECKGS-FLIYPDGDVSRPLVRERLWVNSDF--------NFDNVLS 1077
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIY---------FVTLVILGSFFVLNLVLG 1095
AM+ +F + EGW ++Y DA + IY F+ +I+ +FF++N+ +G
Sbjct: 1078 AMMALFTVSTFEGWPALLYKAIDANAEDEGPIYNYHVEISVFFIVYIIIIAFFMMNIFVG 1137
Query: 1096 VLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIE---PVNEDEQEDEP 1266
+ F RA+G ++ + +L+++ + +++ +A+ + P N +
Sbjct: 1138 FVIITF-------RAQG--EQEYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYR--- 1185
Query: 1267 VAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXX 1446
WA V S F +
Sbjct: 1186 ------------------------VWAT-------------------VNSAAFEYLMFLL 1202
Query: 1447 XXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDC 1626
+HY Q+ ++ + N+ F LF++EM+LK+ + Y +N FD
Sbjct: 1203 ILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFADAWNTFDA 1262
Query: 1627 FVVISSILEFVLVYFDLMKPLG----------VSVLRSARLLRIFKVTKYWTXXXXXXXX 1776
+V+ S+++ + + LG ++ R R++R+ K+
Sbjct: 1263 LIVVGSVVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWT 1322
Query: 1777 XXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQI 1956
GMQ+FG + Q NF TF QA+L +F+
Sbjct: 1323 FIKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRC 1382
Query: 1957 LTGEDWNTVMYHGI-------ESFGGVG---TLG-VIVCIYYIVLFICGNYILLNVFLAI 2103
TGE W +M + ES G G T G +Y+I F+ ++++N+F+A+
Sbjct: 1383 ATGEAWQEIMLASLPGNRCDPESDFGPGEEFTCGSSFAIVYFISFFMLCAFLIINLFVAV 1442
Query: 2104 AVDN 2115
+DN
Sbjct: 1443 IMDN 1446
Score = 107 bits (268), Expect = 3e-21
Identities = 72/283 (25%), Positives = 136/283 (47%), Gaps = 1/283 (0%)
Frame = +1
Query: 3256 KCIEFALKAKPHRRYIPRNR-LQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRG 3432
+C+ +K + R + NR L+ R V S A + + L++ +NT+++A +H+
Sbjct: 497 RCLNKIMKTRICRHFRRANRGLRARCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPLW 556
Query: 3433 FEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPG 3612
+ N + +F E +LK+ L P Y++ +N FD VV G ++ T ++ G
Sbjct: 557 LTQTQEYANKVLLCLFTVEMLLKLYGLGPSVYVASFFNRFDCFVVCGGILETTLVEV--G 614
Query: 3613 GTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIG 3792
+ I+ R R++R+ K+ + L+ + + S +++ + LL+ L I++++G
Sbjct: 615 AMQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLG 674
Query: 3793 MQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSD 3972
MQ FG D T R + F +FP A+L +F+ TGE W +M
Sbjct: 675 MQLFGGKFNFDQTHTKR-STFDTFPQALLTVFQILTGEDWNVVMYD-------GIMAYGG 726
Query: 3973 DYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDN 4101
+ G L YFI F+ +++++N+F+A+ +DN
Sbjct: 727 PFFPGML---------VCVYFIILFICGNYILLNVFLAIAVDN 760
Score = 89.7 bits (221), Expect = 7e-16
Identities = 82/300 (27%), Positives = 123/300 (40%), Gaps = 36/300 (12%)
Frame = +1
Query: 2269 PRRMSE-----VPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVS 2433
PRR ++ A ++ + P+A LF L+ TN R C +V F +L I +
Sbjct: 48 PRRRTQHNKHKTVAVASAQRSPRA--LFCLTLTNPIRRSCISIVEWKPFDILILLTIFAN 105
Query: 2434 SAMLAAEDPLQAN--STRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNL 2607
L P + +T N L +Y F +FTVE LK++ +GLV H ++ RN +NL
Sbjct: 106 CVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNL 165
Query: 2608 LDILVVAVSLTSFVL-----------RTDAMSXXXXXXXXXXXXXXXAINRAKG---LKH 2745
LD ++V V L S +L T + G L
Sbjct: 166 LDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHI 225
Query: 2746 VVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFF-LCNDLSKMTEAECRGEYIHY 2922
V+ ++ A+ + +I L+ + ++AIIG++LF G C L EAE
Sbjct: 226 VLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLGSDMEAE-------- 277
Query: 2923 EDGDPTKPVSKKRVWSNND--------------FNFDNVGDAMISLFVVSTFEGWPQLLY 3060
ED P R + N NFDN AM+++F T EGW +LY
Sbjct: 278 EDPSPCASSGSGRSCTLNHTECRGRWPGPNGGITNFDNFFFAMLTVFQCITMEGWTDVLY 337
Score = 85.9 bits (211), Expect = 1e-14
Identities = 136/690 (19%), Positives = 243/690 (34%), Gaps = 60/690 (8%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIY---QP-YPAQDSDYKNTLLETIEYV 387
N +R C V+ + +L ++ N + +A QP + Q +Y N +L
Sbjct: 515 NRGLRARCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPLWLTQTQEYANKVL------ 568
Query: 388 FIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKM-SIQGFDVKA 564
+ +FT+E +LK+ +G PS Y+ + +N D +V G++ T L ++ ++Q +
Sbjct: 569 -LCLFTVEMLLKLYGLG----PSVYVASFFNRFDCFVVCGGILETTLVEVGAMQPLGISV 623
Query: 565 LRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLH 744
LR R+LR ++ SL ++ ++L +M IA L+L + L I L
Sbjct: 624 LRCVRLLRIFKVTRHWASLSNLVASLLNSM---KSIASLLLLLFLFIIIFSL-------- 672
Query: 745 STCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITN 924
G G F + + +
Sbjct: 673 ------------------LGMQLFGGKFNFDQTHTKRS---------------------T 693
Query: 925 FDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREW-----PWIYFVTLVILGSFFVLNLV 1089
FD F A+LTVFQ ++ E W VMY A G + +YF+ L I G++ +LN+
Sbjct: 694 FDTFPQALLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCVYFIILFICGNYILLNVF 753
Query: 1090 LGV-----LSGEFSKEREKARARGLFQKFREKQQL------EEDLKG-YLDWITQAEDIE 1233
L + SG+ ++K R + ++ ++ ED KG + + E
Sbjct: 754 LAIAVDNLASGDAGTAKDKGREKSSEGNPPKENKVLVPGGENEDAKGARSEGAAPGMEEE 813
Query: 1234 PVNEDEQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVK 1413
E+E+E+E + P + L + N +
Sbjct: 814 EEEEEEEEEEEEEENGAGHVELLQEVVPKEKVVPIPEGSAFFCLSQTNPLRKACHTLIHH 873
Query: 1414 SQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGF-- 1587
+ + +H + F +F++E+LLKM G
Sbjct: 874 HIFTSLILVFIILSSVSLAAEDPIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFL 933
Query: 1588 --TTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXX 1761
++ S FN D VV S++ F + + V +LR R+LR +
Sbjct: 934 HRGSFCRSWFNLLDLLVVSVSLISFGIHSSAISV---VKILRVLRVLRPLRAINRAKGLK 990
Query: 1762 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRA---------- 1911
G+Q+F GKF + K
Sbjct: 991 HVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYSCTDEAKHTLKECKGSFLIY 1050
Query: 1912 --------------------NFDTFVQALLTVFQILTGEDWNTVMYHGI----ESFGGVG 2019
NFD + A++ +F + T E W ++Y I E G +
Sbjct: 1051 PDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDANAEDEGPIY 1110
Query: 2020 TLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
V + +++IV I + ++N+F+ +
Sbjct: 1111 NYHVEISVFFIVYIIIIAFFMMNIFVGFVI 1140
Score = 80.9 bits (198), Expect = 3e-13
Identities = 79/310 (25%), Positives = 127/310 (40%), Gaps = 58/310 (18%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ F+ +I L I N V+L +P S L+ +F +F E VLKIVA
Sbjct: 92 KPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGL 151
Query: 3511 -LNPKNYISDRWNVFDLLVVVGSFIDI--------------TYGKLNPGGTNLISINFFR 3645
L+P YI + WN+ D ++VV + T GK PGG + R
Sbjct: 152 VLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGK--PGG---FDVKALR 206
Query: 3646 LFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV--- 3813
FRV+R ++L+S + +L + MK+ L ++ALL++ + IYA+IG++ F G++
Sbjct: 207 AFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKT 266
Query: 3814 ---------ALDDSTSIHRN------------------------NNFHSFPAAILVLFRS 3894
A +D + + NF +F A+L +F+
Sbjct: 267 CYFLGSDMEAEEDPSPCASSGSGRSCTLNHTECRGRWPGPNGGITNFDNFFFAMLTVFQC 326
Query: 3895 ATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVIN 4074
T E W D++ D G + YF+S + SF V+N
Sbjct: 327 ITMEGWTDVLYWMQD---------------------AMGYELPWVYFVSLVIFGSFFVLN 365
Query: 4075 LFVAVIMDNF 4104
L + V+ F
Sbjct: 366 LVLGVLSGEF 375
Score = 45.1 bits (105), Expect = 0.020
Identities = 23/64 (35%), Positives = 37/64 (56%)
Frame = +1
Query: 1912 NFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNV 2091
NFD F A+LTVFQ +T E W V+Y ++ G + +Y++ L I G++ +LN+
Sbjct: 312 NFDNFFFAMLTVFQCITMEGWTDVLYWMQDAMG-----YELPWVYFVSLVIFGSFFVLNL 366
Query: 2092 FLAI 2103
L +
Sbjct: 367 VLGV 370
>gi|89941|pir||S05011 calcium channel alpha-1 chain, dihydropyridine
sensitive, cardiac (clone HTDHP 2.0) - rabbit (fragment)
Length = 1331
Score = 1007 bits (2604), Expect = 0.0
Identities = 507/831 (61%), Positives = 636/831 (76%), Gaps = 13/831 (1%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNS-FRVFCNMVVNHSYFTNAVLFCILVSSAM 2442
RPR +SE+ V P+P+A S + S FR+ C+ +VN + FTN +LF IL+SS
Sbjct: 149 RPRPLSELHLREAV-PMPEARSQCVSSSAQQQFRIQCHRIVNDTIFTNLILFFILLSSIS 207
Query: 2443 LAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILV 2622
LAAEDP+Q S RN IL YFD FT++FT+EI LK+ +G HKGSFCRN FN+LD+LV
Sbjct: 208 LAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLV 267
Query: 2623 VAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVT 2802
V+VSL SF +++ A++ AINRAKGLKHVVQCV VA++TIGNI++VT
Sbjct: 268 VSVSLISFGIQSSAINVEILRVLRVLRPLR-AINRAKGLKHVVQCVFVAIRTIGNIVIVT 326
Query: 2803 FMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDF 2982
+LQFMFA IGVQLFKG + C+D SK TEAEC+G YI Y+DG+ P+ + R W N+ F
Sbjct: 327 TLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKF 386
Query: 2983 NFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXX 3162
+FDNV M++LF VSTFEGWP+LLY +IDS+ EDKGPI+N R +++
Sbjct: 387 DFDNVLATMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYSIIIAFF 446
Query: 3163 XXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFV 3342
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N+ QY+VW+ V
Sbjct: 447 MMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVV 506
Query: 3343 TSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPK 3522
S FEY++F++I++NT+ LA +HY S F+ +++ N++FTG+F E +LK++A PK
Sbjct: 507 NSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPK 566
Query: 3523 NYISDRWNVFDLLVVVGSFIDITYGKLNPGG------------TNLISINFFRLFRVMRL 3666
+Y D WN FD L+VVGS +DI +++P + ISI FFRLFRVMRL
Sbjct: 567 HYFCDAWNTFDALIVVGSIVDIAITEVHPAEHTQCSPSMNAEENSRISITFFRLFRVMRL 626
Query: 3667 VKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRN 3846
VKLLSRGEGIRTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL+D+T I+RN
Sbjct: 627 VKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRN 686
Query: 3847 NNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAY 4026
NNF +FP A+L+LFR ATGEAWQDIML+C + +C P S+ H E+ CG+ FA
Sbjct: 687 NNFQTFPQAVLLLFRCATGEAWQDIMLACMPGK--KCAPESEP-HNSTEGETPCGSTFAV 743
Query: 4027 PYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIK 4206
YFISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+W+EYDP+AKGRIK
Sbjct: 744 FYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIK 803
Query: 4207 HLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIY 4386
HLDVVTLLR+I PPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFALVRT L+I
Sbjct: 804 HLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIK 863
Query: 4387 TEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFK 4566
TEGN+++ANE+LR+ IK+IWKRT LLD+VVPPAG +D+VTVGKFYATFLIQ+YFR+FK
Sbjct: 864 TEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQEYFRKFK 922
Query: 4567 KRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDE 4719
KRKE G P+Q A++LQAGLRTLH+IGPE++RAISG+L + D+
Sbjct: 923 KRKEQGLVG-KPSQR-NALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDK 971
Score = 119 bits (298), Expect = 8e-25
Identities = 96/342 (28%), Positives = 157/342 (45%), Gaps = 10/342 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP LR+ + R C IV F LILF I + I+L
Sbjct: 149 RPRPLSELHLREAVPMPEARSQCVSSSAQQQFRIQCHRIVNDTIFTNLILFFILLSSISL 208
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P Q + ++N +L + VF +FTIE LK+ A G H ++ RN +NILD +
Sbjct: 209 AAEDP--VQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLL 266
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S + +I +V+ LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 267 VVSVSLISFGIQSSAI---NVEILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIV 323
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ-KDPTPCGTDTEGSAFKCQPSDSL 852
++ + ++A IG++LF GKL+ TC D + A+ K D E QP
Sbjct: 324 IVTTLLQFMFACIGVQLFKGKLY-TCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRS-- 380
Query: 853 TNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWP 1032
WE N +FDN M+ +F + EGW +++Y D+ +
Sbjct: 381 ------WE-----------NSKFDFDNVLATMMALFTVSTFEGWPELLYRSIDSHTEDKG 423
Query: 1033 WIY---------FVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
IY F+ I+ +FF++N+ +G + F ++ E+
Sbjct: 424 PIYNYRVEISIFFIIYSIIIAFFMMNIFVGFVIVTFQEQGEQ 465
Score = 90.1 bits (222), Expect = 6e-16
Identities = 42/57 (73%), Positives = 51/57 (88%)
Frame = +1
Query: 1975 NTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNA 2145
N+VMY GI ++GG G++VCIY+I+LFICGNYILLNVFLAIAVDNLADA+SLT+A
Sbjct: 1 NSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSA 57
Score = 82.0 bits (201), Expect = 1e-13
Identities = 73/315 (23%), Positives = 129/315 (40%), Gaps = 33/315 (10%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+L+ +I N I LA+ Q Y Q +K + + +F +FT+E +LK++A F
Sbjct: 511 FEYLMFVLILLNTICLAM-QHY-GQSCLFK-IAMNILNMLFTGLFTVEMILKLIA----F 563
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKM---------------SIQGFDVKALRAFRV 582
P Y +AWN D +IVV +V ++++ + R FRV
Sbjct: 564 KPKHYFCDAWNTFDALIVVGSIVDIAITEVHPAEHTQCSPSMNAEENSRISITFFRLFRV 623
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
+R ++L+S ++ +L +++ L ++ALL++ + IYA+IG+++F
Sbjct: 624 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF----------- 672
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
G++A D T N NF F
Sbjct: 673 --GKIALNDTTEI------------------------------------NRNNNFQTFPQ 694
Query: 943 AMLTVFQCVSLEGWTDVMYWV------------------NDAVGREWPWIYFVTLVILGS 1068
A+L +F+C + E W D+M G + YF++ +L +
Sbjct: 695 AVLLLFRCATGEAWQDIMLACMPGKKCAPESEPHNSTEGETPCGSTFAVFYFISFYMLCA 754
Query: 1069 FFVLNLVLGVLSGEF 1113
F ++NL + V+ F
Sbjct: 755 FLIINLFVAVIMDNF 769
Score = 68.6 bits (166), Expect = 2e-09
Identities = 55/240 (22%), Positives = 95/240 (38%), Gaps = 27/240 (11%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HYGQS + N+ F LF++EM+LK+ + Y +N FD +V+ SI++
Sbjct: 529 QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDI 588
Query: 1657 VLVYF--------------DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXX 1794
+ + + ++ R R++R+ K+
Sbjct: 589 AITEVHPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQ 648
Query: 1795 XXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDW 1974
GMQVFG + + NF TF QA+L +F+ TGE W
Sbjct: 649 ALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAW 708
Query: 1975 NTVMYHGI-------ESFGGVGTLGVIVC------IYYIVLFICGNYILLNVFLAIAVDN 2115
+M + ES T G C Y+I ++ ++++N+F+A+ +DN
Sbjct: 709 QDIMLACMPGKKCAPESEPHNSTEGETPCGSTFAVFYFISFYMLCAFLIINLFVAVIMDN 768
Score = 41.6 bits (96), Expect = 0.22
Identities = 45/240 (18%), Positives = 86/240 (35%), Gaps = 38/240 (15%)
Frame = +1
Query: 1504 DHFQTMANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYF 1671
+H ++ F +F++E+ LKM + G ++ + FN D VV S++ F +
Sbjct: 221 NHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQ-- 278
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+ V +LR R+LR +
Sbjct: 279 --SSAINVEILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACI 336
Query: 1852 GMQVFGGKFNFNPQQPK------------------------PRA------NFDTFVQALL 1941
G+Q+F GK K PR+ +FD + ++
Sbjct: 337 GVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLATMM 396
Query: 1942 TVFQILTGEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+F + T E W ++Y I+S G + V + I++I+ I + ++N+F+ +
Sbjct: 397 ALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYSIIIAFFMMNIFVGFVI 456
>gi|34933395|ref|XP_346866.1| hypothetical protein XP_346865 [Rattus
norvegicus]
Length = 1980
Score = 1006 bits (2601), Expect = 0.0
Identities = 505/838 (60%), Positives = 632/838 (75%), Gaps = 10/838 (1%)
Frame = +1
Query: 2278 MSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAED 2457
+ EV V PIP+ S+ F LS TN R C+ +++H FT+ +L I++SS LAAED
Sbjct: 832 LQEVVPKEKVVPIPEGSAFFCLSQTNPLRKACHTLIHHHVFTSLILVFIILSSVSLAAED 891
Query: 2458 PLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSL 2637
P++A+S RN IL YFDY FTS+FTVEI LK+ VFG H+GSFCR+ FNLLD+LVV+VSL
Sbjct: 892 PIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFLHQGSFCRSWFNLLDLLVVSVSL 951
Query: 2638 TSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQF 2817
SF + + A+S AINRAKGLKHVVQCV VA++TIGNIM+VT +LQF
Sbjct: 952 ISFGIHSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQF 1011
Query: 2818 MFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNV 2997
MFA IGVQLFKG F+ C D +K T EC+G ++ Y DGD ++P+ ++R+W N+DFNFDNV
Sbjct: 1012 MFACIGVQLFKGKFYSCTDEAKHTLKECKGSFLIYPDGDVSRPLVRERLWVNSDFNFDNV 1071
Query: 2998 GDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXX 3177
AM++LF VSTFEGWP LLY AID++ ED+GPI+N +++
Sbjct: 1072 LSAMMALFTVSTFEGWPALLYKAIDAHAEDEGPIYNYHVEISVFFIVYIIIIAFFMMNIF 1131
Query: 3178 XGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVTSRAF 3357
GFVI+TF+ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N QYRVW V S AF
Sbjct: 1132 VGFVIITFRAQGEQEYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWATVNSAAF 1191
Query: 3358 EYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISD 3537
EY++FL+I++NTV+LA +HY + F +D+ N++FTG+F E VLKI+A PK+Y +D
Sbjct: 1192 EYLMFLLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTVEMVLKIIAFKPKHYFAD 1251
Query: 3538 RWNVFDLLVVVGSFIDITYGKLNPGG--------TNLISINFFRLFRVMRLVKLLSRGEG 3693
WN FD L+VVGS +DI ++N GG ++ ISI FFRLFRVMRLVKLLS+GEG
Sbjct: 1252 AWNTFDALIVVGSVVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLLSKGEG 1311
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAA 3873
IRTLLWTF+KSFQALPYVALLI ++FFIYAVIGMQ FGKVAL D T I+RNNNF +FP A
Sbjct: 1312 IRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQA 1371
Query: 3874 ILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFML 4053
+L+LFR ATGEAWQ+IML+ RCDP SD G E CG+NFA YFISFFML
Sbjct: 1372 VLLLFRCATGEAWQEIMLASLPGN--RCDPESDF---GPGEEFTCGSNFAIVYFISFFML 1426
Query: 4054 CSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLR 4233
C+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+WSEYDP AKGRIKHLDVV LLR
Sbjct: 1427 CAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLR 1486
Query: 4234 KISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNIDEAN 4413
+I PPLGFGKLCPHR+ACKRLV+MN+PLNSDGTV FNATLFALVRT+L+I TEGN+D+AN
Sbjct: 1487 RIQPPLGFGKLCPHRVACKRLVAMNVPLNSDGTVTFNATLFALVRTSLRIKTEGNLDQAN 1546
Query: 4414 EQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEMEAKG 4593
++LR IK+IWKR + LLDEV+PP E++VTVGKFYATFLIQDYFR+F++RKE KG
Sbjct: 1547 QELRMVIKKIWKRIKQKLLDEVIPPP-DEEEVTVGKFYATFLIQDYFRKFRRRKE---KG 1602
Query: 4594 VLPAQTPQAMA--LQAGLRTLHEIGPELKRAISGNLETDFNFDEPEPQHRRPHSLFNN 4761
+L A P + + LQAGLR+L ++GPE+++A++ + E + +E Q NN
Sbjct: 1603 LLGADAPTSTSSVLQAGLRSLQDLGPEIRQALTYDTEEEEEEEEAAGQEAEEEEAENN 1660
Score = 449 bits (1155), Expect = e-124
Identities = 223/349 (63%), Positives = 270/349 (76%), Gaps = 12/349 (3%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR+ CISIVEWKPF+ LIL I ANC+AL +Y P+P DS+ N LE +EYVF+V+F
Sbjct: 79 NPIRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIF 138
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQ------------ 546
T+E VLKIVA G + HPSAY+RN WN+LDFIIVV+GL S +L + +
Sbjct: 139 TVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPG 198
Query: 547 GFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLEL 726
GFDVKALRAFRVLRPLRLVSGVPSL +VLN+I++A++PLLHIALLVLFVI+IYAIIGLEL
Sbjct: 199 GFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLEL 258
Query: 727 FCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGP 906
F G++H TC + A++DP+PC + GS C + + EC WPGP
Sbjct: 259 FLGRMHKTCYFLGSDMEAEEDPSPCASS--GSGRSCTLNQT--------ECRGR--WPGP 306
Query: 907 NNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNL 1086
N GITNFDNF AMLTVFQC+++EGWTDV+YW+ DA+G E PW+YFV+LVI GSFFVLNL
Sbjct: 307 NGGITNFDNFFFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNL 366
Query: 1087 VLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIE 1233
VLGVLSGEFSKEREKA+ARG FQK REKQQ+EEDL+GYLDWITQAE+++
Sbjct: 367 VLGVLSGEFSKEREKAKARGDFQKLREKQQMEEDLRGYLDWITQAEELD 415
Score = 241 bits (615), Expect = 1e-61
Identities = 126/242 (52%), Positives = 147/242 (60%)
Frame = +1
Query: 1408 VKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGF 1587
VKS YW SEH+GQ WL Q AN + LF++EMLLK+Y LG
Sbjct: 526 VKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQTQEYANKVLLCLFTVEMLLKLYGLGP 585
Query: 1588 TTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXX 1767
+ Y S FNRFDCFVV ILE LV M+PLG+SVLR RLLRIFKVT++W
Sbjct: 586 SVYVASFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASLSNL 645
Query: 1768 XXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTV 1947
GMQ+FGGKFNF+ K R+ FDTF QALLTV
Sbjct: 646 VASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTK-RSTFDTFPQALLTV 704
Query: 1948 FQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADA 2127
FQILTGEDWN VMY GI ++GG G++VC+Y+I+LFICGNYILLNVFLAIAVDNLA
Sbjct: 705 FQILTGEDWNVVMYDGIMAYGGPFFPGMLVCVYFIILFICGNYILLNVFLAIAVDNLASG 764
Query: 2128 DS 2133
D+
Sbjct: 765 DA 766
Score = 171 bits (433), Expect = 2e-40
Identities = 157/664 (23%), Positives = 280/664 (41%), Gaps = 33/664 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+RK C +++ F LIL I + ++LA P A ++N +L +Y F +F
Sbjct: 857 NPLRKACHTLIHHHVFTSLILVFIILSSVSLAAEDPIRAHS--FRNHILGYFDYAFTSIF 914
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
T+E +LK+ G H ++ R+ +N+LD ++V + L+S + +I VK LR RV
Sbjct: 915 TVEILLKMTVFGAFLHQGSFCRSWFNLLDLLVVSVSLISFGIHSSAIS--VVKILRVLRV 972
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLR ++ L+ V+ + A+ + +I ++ + ++A IG++LF GK +S C D
Sbjct: 973 LRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYS-CTDE 1031
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
A L + +GS F P ++ VR N+ + NFDN
Sbjct: 1032 AKHTL---------KECKGS-FLIYPDGDVSRPLVRERLWVNSDF--------NFDNVLS 1073
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIY---------FVTLVILGSFFVLNLVLG 1095
AM+ +F + EGW ++Y DA + IY F+ +I+ +FF++N+ +G
Sbjct: 1074 AMMALFTVSTFEGWPALLYKAIDAHAEDEGPIYNYHVEISVFFIVYIIIIAFFMMNIFVG 1133
Query: 1096 VLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIE---PVNEDEQEDEP 1266
+ F RA+G ++ + +L+++ + +++ +A+ + P N +
Sbjct: 1134 FVIITF-------RAQG--EQEYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYR--- 1181
Query: 1267 VAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXX 1446
WA V S F +
Sbjct: 1182 ------------------------VWAT-------------------VNSAAFEYLMFLL 1198
Query: 1447 XXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDC 1626
+HY Q+ ++ + N+ F LF++EM+LK+ + Y +N FD
Sbjct: 1199 ILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTVEMVLKIIAFKPKHYFADAWNTFDA 1258
Query: 1627 FVVISSILEFVLVYFDLMKPLG----------VSVLRSARLLRIFKVTKYWTXXXXXXXX 1776
+V+ S+++ + + LG ++ R R++R+ K+
Sbjct: 1259 LIVVGSVVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWT 1318
Query: 1777 XXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQI 1956
GMQ+FG + Q NF TF QA+L +F+
Sbjct: 1319 FIKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRC 1378
Query: 1957 LTGEDWNTVMYHGI-------ESFGGVG---TLGV-IVCIYYIVLFICGNYILLNVFLAI 2103
TGE W +M + ES G G T G +Y+I F+ ++++N+F+A+
Sbjct: 1379 ATGEAWQEIMLASLPGNRCDPESDFGPGEEFTCGSNFAIVYFISFFMLCAFLIINLFVAV 1438
Query: 2104 AVDN 2115
+DN
Sbjct: 1439 IMDN 1442
Score = 108 bits (271), Expect = 1e-21
Identities = 77/301 (25%), Positives = 142/301 (46%), Gaps = 1/301 (0%)
Frame = +1
Query: 3202 QNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR-LQYRVWWFVTSRAFEYVIFLI 3378
++E E +C L C+ +K K R + NR L+ R V S A + + L+
Sbjct: 485 EDEEEGTMASCTL------CLNKIMKTKVCRHFRRANRGLRARCRRAVKSNACYWAVLLL 538
Query: 3379 IVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDL 3558
+ +NT+++A +H+ + N + +F E +LK+ L P Y++ +N FD
Sbjct: 539 VFLNTLTIASEHHGQPVWLTQTQEYANKVLLCLFTVEMLLKLYGLGPSVYVASFFNRFDC 598
Query: 3559 LVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQAL 3738
VV G ++ T ++ G + I+ R R++R+ K+ + L+ + + S +++
Sbjct: 599 FVVCGGILETTLVEV--GAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKSI 656
Query: 3739 PYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQD 3918
+ LL+ L I++++GMQ FG D T R + F +FP A+L +F+ TGE W
Sbjct: 657 ASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKR-STFDTFPQALLTVFQILTGEDWNV 715
Query: 3919 IMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMD 4098
+M + G L YFI F+ +++++N+F+A+ +D
Sbjct: 716 VMYD-------GIMAYGGPFFPGML---------VCVYFIILFICGNYILLNVFLAIAVD 759
Query: 4099 N 4101
N
Sbjct: 760 N 760
Score = 89.0 bits (219), Expect = 1e-15
Identities = 76/275 (27%), Positives = 112/275 (40%), Gaps = 31/275 (11%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN--STRNMILNYF 2502
+LF L+ TN R C +V F +L I + L P + +T N L
Sbjct: 71 ALFCLTLTNPIRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQV 130
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL---------- 2652
+Y F +FTVE LK++ +GLV H ++ RN +NLLD ++V V L S +L
Sbjct: 131 EYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDA 190
Query: 2653 -RTDAMSXXXXXXXXXXXXXXXAINRAKG---LKHVVQCVIVAVKTIGNIMLVTFMLQFM 2820
T + G L V+ ++ A+ + +I L+ + +
Sbjct: 191 PHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIII 250
Query: 2821 FAIIGVQLFKGTFF-LCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNND------ 2979
+AIIG++LF G C L EAE ED P R + N
Sbjct: 251 YAIIGLELFLGRMHKTCYFLGSDMEAE--------EDPSPCASSGSGRSCTLNQTECRGR 302
Query: 2980 --------FNFDNVGDAMISLFVVSTFEGWPQLLY 3060
NFDN AM+++F T EGW +LY
Sbjct: 303 WPGPNGGITNFDNFFFAMLTVFQCITMEGWTDVLY 337
Score = 86.7 bits (213), Expect = 6e-15
Identities = 137/691 (19%), Positives = 245/691 (34%), Gaps = 61/691 (8%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIY---QP-YPAQDSDYKNTLLETIEYV 387
N +R C V+ + +L ++ N + +A QP + Q +Y N +L
Sbjct: 515 NRGLRARCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQTQEYANKVL------ 568
Query: 388 FIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKM-SIQGFDVKA 564
+ +FT+E +LK+ +G PS Y+ + +N D +V G++ T L ++ ++Q +
Sbjct: 569 -LCLFTVEMLLKLYGLG----PSVYVASFFNRFDCFVVCGGILETTLVEVGAMQPLGISV 623
Query: 565 LRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLH 744
LR R+LR ++ SL ++ ++L +M IA L+L + L I L
Sbjct: 624 LRCVRLLRIFKVTRHWASLSNLVASLLNSM---KSIASLLLLLFLFIIIFSL-------- 672
Query: 745 STCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITN 924
G G F + + +
Sbjct: 673 ------------------LGMQLFGGKFNFDQTHTKRS---------------------T 693
Query: 925 FDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREW-----PWIYFVTLVILGSFFVLNLV 1089
FD F A+LTVFQ ++ E W VMY A G + +YF+ L I G++ +LN+
Sbjct: 694 FDTFPQALLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCVYFIILFICGNYILLNVF 753
Query: 1090 LGV-----LSGEFSKEREKARARGLFQKFREKQQL------EEDLKGYLDWITQAEDIEP 1236
L + SG+ ++K R + ++ ++ ED +G T++E P
Sbjct: 754 LAIAVDNLASGDAGAAKDKGREKSSEGNPPQENKVLVPGGENEDTEG-----TKSEGAAP 808
Query: 1237 --VNEDEQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLV 1410
E+E+E+E + P + L + N +
Sbjct: 809 GMEEEEEEEEEEEEENGAGHVELLQEVVPKEKVVPIPEGSAFFCLSQTNPLRKACHTLIH 868
Query: 1411 KSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGF- 1587
+ + +H + F +F++E+LLKM G
Sbjct: 869 HHVFTSLILVFIILSSVSLAAEDPIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAF 928
Query: 1588 ---TTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXX 1758
++ S FN D VV S++ F + + V +LR R+LR +
Sbjct: 929 LHQGSFCRSWFNLLDLLVVSVSLISFGIHSSAISV---VKILRVLRVLRPLRAINRAKGL 985
Query: 1759 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRA--------- 1911
G+Q+F GKF + K
Sbjct: 986 KHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYSCTDEAKHTLKECKGSFLI 1045
Query: 1912 ---------------------NFDTFVQALLTVFQILTGEDWNTVMYHGI----ESFGGV 2016
NFD + A++ +F + T E W ++Y I E G +
Sbjct: 1046 YPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDAHAEDEGPI 1105
Query: 2017 GTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
V + +++IV I + ++N+F+ +
Sbjct: 1106 YNYHVEISVFFIVYIIIIAFFMMNIFVGFVI 1136
Score = 81.3 bits (199), Expect = 3e-13
Identities = 80/310 (25%), Positives = 130/310 (41%), Gaps = 58/310 (18%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ F+ +I L I N V+L +P S L+ +F +F E VLKIVA
Sbjct: 92 KPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGL 151
Query: 3511 -LNPKNYISDRWNVFDLLVVVGSFIDI--------------TYGKLNPGGTNLISINFFR 3645
L+P YI + WN+ D ++VV + T GK PGG + R
Sbjct: 152 VLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGK--PGG---FDVKALR 206
Query: 3646 LFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV--- 3813
FRV+R ++L+S + +L + MK+ L ++ALL++ + IYA+IG++ F G++
Sbjct: 207 AFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKT 266
Query: 3814 ---------ALDD-----------STSIHRN-------------NNFHSFPAAILVLFRS 3894
A +D S ++++ NF +F A+L +F+
Sbjct: 267 CYFLGSDMEAEEDPSPCASSGSGRSCTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQC 326
Query: 3895 ATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVIN 4074
T E W D++ D G + YF+S + SF V+N
Sbjct: 327 ITMEGWTDVLYWMQD---------------------AMGYELPWVYFVSLVIFGSFFVLN 365
Query: 4075 LFVAVIMDNF 4104
L + V+ F
Sbjct: 366 LVLGVLSGEF 375
Score = 45.1 bits (105), Expect = 0.020
Identities = 23/64 (35%), Positives = 37/64 (56%)
Frame = +1
Query: 1912 NFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNV 2091
NFD F A+LTVFQ +T E W V+Y ++ G + +Y++ L I G++ +LN+
Sbjct: 312 NFDNFFFAMLTVFQCITMEGWTDVLYWMQDAMG-----YELPWVYFVSLVIFGSFFVLNL 366
Query: 2092 FLAI 2103
L +
Sbjct: 367 VLGV 370
>gi|466355|gb|AAA17030.1| L-type calcium channel (HFCC)
Length = 2221
Score = 1005 bits (2599), Expect = 0.0
Identities = 512/878 (58%), Positives = 641/878 (72%), Gaps = 60/878 (6%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPR +SE+ P+P+AS+ FI S N FR+ C+ +VN + FTN +LF IL+SS L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 2446 AAEDPLQANSTRNMILNYFD--------------------YFFTSVFTVEITLKVIVFGL 2565
AAEDP+Q S RN IL YFD Y FTS+FT+EI LK+ +G
Sbjct: 918 AAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVFTSIFTLEIILKMTAYGA 977
Query: 2566 VFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKH 2745
HKGSFCRN FN+LD+LVV+VSL SF +++ A++ AINRAKGLKH
Sbjct: 978 FLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKH 1037
Query: 2746 VVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYE 2925
VVQCV VA++TIGNI++VT +LQFMFA IGVQLFKG + C+D SK TEAEC+G YI Y+
Sbjct: 1038 VVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYK 1097
Query: 2926 DGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHN 3105
DG+ P+ + R W N+ F+FDNV AM++LF VSTFEGWP+LLY +IDS+ EDKGPI+N
Sbjct: 1098 DGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYN 1157
Query: 3106 SRQAVALXXXXXXXXXXXXXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAK 3285
R +++ GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+
Sbjct: 1158 YRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKAR 1217
Query: 3286 PHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLI 3465
P RRYIP+N+ QY+VW+ V S FEY++F++I++NT+ LA +HY S F+ +++ N++
Sbjct: 1218 PLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNML 1277
Query: 3466 FTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGK--------------- 3600
FTG+F E +LK++A PK Y SD WNVFD L+V+GS ID+ +
Sbjct: 1278 FTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDAL 1337
Query: 3601 -------------------------LNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTL 3705
+N + ISI FFRLFRVMRLVKLLSRGEGIRTL
Sbjct: 1338 IVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTL 1397
Query: 3706 LWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVL 3885
LWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL+D+T I+RNNNF +FP A+L+L
Sbjct: 1398 LWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLL 1457
Query: 3886 FRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFL 4065
FR ATGEAWQDIML+C + +C P S+ + E+ CG++FA YFISF+MLC+FL
Sbjct: 1458 FRCATGEAWQDIMLACMPGK--KCAPESEPSNSTE-GETPCGSSFAVFYFISFYMLCAFL 1514
Query: 4066 VINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+W+EYDP+AKGRIKHLDVVTLLR+I P
Sbjct: 1515 IINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQP 1574
Query: 4246 PLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNIDEANEQLR 4425
PLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFALVRT L+I TEGN+++ANE+LR
Sbjct: 1575 PLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELR 1634
Query: 4426 SAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEMEAKGVLPA 4605
+ IK+IWKRT LLD+VVPPAG +D+VTVGKFYATFLIQ+YFR+FKKRKE G P+
Sbjct: 1635 AIIKKIWKRTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQEYFRKFKKRKEQGLVG-KPS 1692
Query: 4606 QTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDE 4719
Q A++LQAGLRTLH+IGPE++RAISG+L + D+
Sbjct: 1693 QR-NALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDK 1729
Score = 722 bits (1863), Expect = 0.0
Identities = 383/698 (54%), Positives = 459/698 (64%), Gaps = 28/698 (4%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXX-XXXNNPIRKLCISIVEWKPFEFLILFMICANCIA 312
+KR KP +Q + NPIR+ CISIVEWKPFE +IL I ANC+A
Sbjct: 81 RKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVA 140
Query: 313 LAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDF 492
LAIY P+P DS+ N+ LE +EY+F+++FT+E LK++A G +FHP+AYLRN WN+LDF
Sbjct: 141 LAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDF 200
Query: 493 IIVVIGLVSTILSKMSIQ-----------GFDVKALRAFRVLRPLRLVSGVPSLQVVLNA 639
IIVV+GL S IL + + GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+
Sbjct: 201 IIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNS 260
Query: 640 ILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPA--TGQLAQKDPTPCGTDT 813
I++AM+PLLHIALLVLFVI+IYAIIGLELF GK+H TC + A+ DP+PC +T
Sbjct: 261 IIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALET 320
Query: 814 EGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDV 993
G +CQ + ++ G W GP +GITNFDNF AMLTVFQC+++EGWTDV
Sbjct: 321 -GHGRQCQ-NGTVCKPG----------WDGPKHGITNFDNFAFAMLTVFQCITMEGWTDV 368
Query: 994 MYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQ 1173
+YWVNDAVGR+WPWIYFVTL+I+GSFFVLNLVLGVLSGEFSKEREKA+ARG FQK REKQ
Sbjct: 369 LYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 428
Query: 1174 QLEEDLKGYLDWITQAEDIEPVNEDEQEDE--------PVAQTXXXXXXXXXXXXXXXXX 1329
QLEEDLKGYLDWITQAEDI+P NEDE DE P ++T
Sbjct: 429 QLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGEN 488
Query: 1330 XPSKWAARMKRLE------KLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQ 1491
++ A R+ + + + N VKS FYW SEHY Q
Sbjct: 489 CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQ 548
Query: 1492 SEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYF 1671
WL Q AN + LF+ EMLLKMYSLG Y S FNRFDCFVV ILE +LV
Sbjct: 549 PNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+M PLG+SVLR RLLRIFK+T+YW
Sbjct: 609 KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668
Query: 1852 GMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGV 2031
GMQ+FGGKFNF+ Q + R+ FD F Q+LLTVFQILTGEDWN+VMY GI ++GG G+
Sbjct: 669 GMQLFGGKFNFDEMQTR-RSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGM 727
Query: 2032 IVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNA 2145
+VCIY+I+LFICGNYILLNVFLAIAVDNLADA+SLT+A
Sbjct: 728 LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSA 765
Score = 120 bits (301), Expect = 4e-25
Identities = 103/362 (28%), Positives = 164/362 (44%), Gaps = 30/362 (8%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V NN R C IV F LILF I + I+L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 316 AIYQPYPAQDSDYKN----------TLLETIE----------YVFIVVFTIECVLKIVAM 435
A P Q + ++N T + TIE YVF +FT+E +LK+ A
Sbjct: 918 AAEDP--VQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVFTSIFTLEIILKMTAY 975
Query: 436 GFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVP 615
G H ++ RN +NILD ++V + L+S + +I VK LR RVLRPLR ++
Sbjct: 976 GAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINV--VKILRVLRVLRPLRAINRAK 1033
Query: 616 SLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ-KDP 792
L+ V+ + A+ + +I ++ + ++A IG++LF GKL+ TC D + A+ K
Sbjct: 1034 GLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLY-TCSDSSKQTEAECKGN 1092
Query: 793 TPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVS 972
D E QP WE N +FDN AM+ +F +
Sbjct: 1093 YITYKDGEVDHPIIQPRS--------WE-----------NSKFDFDNVLAAMMALFTVST 1133
Query: 973 LEGWTDVMYWVNDAVGREWPWIY---------FVTLVILGSFFVLNLVLGVLSGEFSKER 1125
EGW +++Y D+ + IY F+ +I+ +FF++N+ +G + F ++
Sbjct: 1134 FEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQG 1193
Query: 1126 EK 1131
E+
Sbjct: 1194 EQ 1195
Score = 95.9 bits (237), Expect = 1e-17
Identities = 64/259 (24%), Positives = 124/259 (47%), Gaps = 5/259 (1%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S F +++ ++ +NT+++A +HY + D N +F E +LK+ +L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD VV G ++ + + + I+ R R++R+ K+ +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL--VETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + + S +++ + LL+ L I++++GMQ F GK D+ + R + F +FP ++
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT--RRSTFDNFPQSL 696
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNF----AYPYFISF 4044
L +F+ TGE W +M D G G +F YFI
Sbjct: 697 LTVFQILTGEDWNSVMY--------------DGIMAYG------GPSFPGMLVCIYFIIL 736
Query: 4045 FMLCSFLVINLFVAVIMDN 4101
F+ +++++N+F+A+ +DN
Sbjct: 737 FICGNYILLNVFLAIAVDN 755
Score = 90.9 bits (224), Expect = 3e-16
Identities = 88/353 (24%), Positives = 148/353 (40%), Gaps = 54/353 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE +I L I N V+LA +P S L+ +F +F EA LK++A
Sbjct: 124 KPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGL 183
Query: 3511 -LNPKNYISDRWNVFD-LLVVVGSFIDITYGKLNPGGTNLIS-------INFFRLFRVMR 3663
+P Y+ + WN+ D ++VVVG F I G N + + R FRV+R
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLR 243
Query: 3664 LVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV--------- 3813
++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F GK+
Sbjct: 244 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEG 303
Query: 3814 -----ALDDSTSI------------------------HRNNNFHSFPAAILVLFRSATGE 3906
A DD + H NF +F A+L +F+ T E
Sbjct: 304 IADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITME 363
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVA 4086
W D++ +D G ++ + YF++ ++ SF V+NL +
Sbjct: 364 GWTDVLYWVND---------------------AVGRDWPWIYFVTLIIIGSFFVLNLVLG 402
Query: 4087 VIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
V+ F G + +R + + D KG +LD +T I P
Sbjct: 403 VLSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 449
Score = 89.0 bits (219), Expect = 1e-15
Identities = 77/282 (27%), Positives = 122/282 (42%), Gaps = 29/282 (10%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR--NMILNYF 2502
+L L+ N R C +V F +L I + LA P + + N L
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL----RTDAMS 2670
+Y F +FTVE LKVI +GL+FH ++ RN +NLLD ++V V L S +L + D +
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 2671 XXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
A ++ L+ V+ +I A+ + +I L+ + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 2824 AIIGVQLFKGTFF-LCNDLSKMTE-------AECRGEYIH---YEDGDPTKPVSKKRVW- 2967
AIIG++LF G C + + + + C E H ++G KP W
Sbjct: 283 AIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKP-----GWD 337
Query: 2968 --SNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEED 3087
+ NFDN AM+++F T EGW +LY D+ D
Sbjct: 338 GPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRD 379
Score = 79.7 bits (195), Expect = 7e-13
Identities = 75/343 (21%), Positives = 132/343 (37%), Gaps = 61/343 (17%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+L+ +I N I LA+ Q Y Q +K + + +F +FT+E +LK++A F
Sbjct: 1241 FEYLMFVLILLNTICLAM-QHY-GQSCLFK-IAMNILNMLFTGLFTVEMILKLIA----F 1293
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD------------------------ 555
P Y + WN+ DF+IV+ ++ ILS+ + D
Sbjct: 1294 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNP 1353
Query: 556 -------------------VKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIAL 678
+ R FRV+R ++L+S ++ +L +++ L ++AL
Sbjct: 1354 AEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVAL 1413
Query: 679 LVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTN 858
L++ + IYA+IG+++F G++A D T
Sbjct: 1414 LIVMLFFIYAVIGMQVF-------------GKIALNDTTEI------------------- 1441
Query: 859 MGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWV----------- 1005
N NF F A+L +F+C + E W D+M
Sbjct: 1442 -----------------NRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESE 1484
Query: 1006 -------NDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
G + YF++ +L +F ++NL + V+ F
Sbjct: 1485 PSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1527
Score = 62.4 bits (150), Expect = 1e-07
Identities = 60/268 (22%), Positives = 100/268 (36%), Gaps = 55/268 (20%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HYGQS + N+ F LF++EM+LK+ + Y + +N FD +VI SI++
Sbjct: 1259 QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDV 1318
Query: 1657 VLVY-----------FDLMKPLG-------------------------------VSVLRS 1710
+L FD + +G ++ R
Sbjct: 1319 ILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRL 1378
Query: 1711 ARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNP 1890
R++R+ K+ GMQVFG +
Sbjct: 1379 FRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDT 1438
Query: 1891 QQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGI-------ESFGGVGTLGVIVC--- 2040
+ NF TF QA+L +F+ TGE W +M + ES T G C
Sbjct: 1439 TEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSS 1498
Query: 2041 ---IYYIVLFICGNYILLNVFLAIAVDN 2115
Y+I ++ ++++N+F+A+ +DN
Sbjct: 1499 FAVFYFISFYMLCAFLIINLFVAVIMDN 1526
Score = 42.0 bits (97), Expect = 0.17
Identities = 46/234 (19%), Positives = 86/234 (36%), Gaps = 38/234 (16%)
Frame = +1
Query: 1522 ANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPL 1689
A+ F +F++E++LKM + G ++ + FN D VV S++ F + +
Sbjct: 956 ADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINV-- 1013
Query: 1690 GVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFG 1869
V +LR R+LR + G+Q+F
Sbjct: 1014 -VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFK 1072
Query: 1870 GKFNFNPQQPK------------------------PRA------NFDTFVQALLTVFQIL 1959
GK K PR+ +FD + A++ +F +
Sbjct: 1073 GKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVS 1132
Query: 1960 TGEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
T E W ++Y I+S G + V + I++I+ I + ++N+F+ +
Sbjct: 1133 TFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1186
>gi|6165981|sp|Q13936|CCAC_HUMAN Voltage-dependent L-type calcium
channel alpha-1C subunit (Voltage-gated calcium channel
alpha subunit Cav1.2) (Calcium channel, L type, alpha-1
polypeptide, isoform 1, cardiac muscle)
Length = 2221
Score = 1005 bits (2599), Expect = 0.0
Identities = 512/878 (58%), Positives = 641/878 (72%), Gaps = 60/878 (6%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPR +SE+ P+P+AS+ FI S N FR+ C+ +VN + FTN +LF IL+SS L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 2446 AAEDPLQANSTRNMILNYFD--------------------YFFTSVFTVEITLKVIVFGL 2565
AAEDP+Q S RN IL YFD Y FTS+FT+EI LK+ +G
Sbjct: 918 AAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVFTSIFTLEIILKMTAYGA 977
Query: 2566 VFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKH 2745
HKGSFCRN FN+LD+LVV+VSL SF +++ A++ AINRAKGLKH
Sbjct: 978 FLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKH 1037
Query: 2746 VVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYE 2925
VVQCV VA++TIGNI++VT +LQFMFA IGVQLFKG + C+D SK TEAEC+G YI Y+
Sbjct: 1038 VVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYK 1097
Query: 2926 DGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHN 3105
DG+ P+ + R W N+ F+FDNV AM++LF VSTFEGWP+LLY +IDS+ EDKGPI+N
Sbjct: 1098 DGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYN 1157
Query: 3106 SRQAVALXXXXXXXXXXXXXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAK 3285
R +++ GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+
Sbjct: 1158 YRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKAR 1217
Query: 3286 PHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLI 3465
P RRYIP+N+ QY+VW+ V S FEY++F++I++NT+ LA +HY S F+ +++ N++
Sbjct: 1218 PLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNML 1277
Query: 3466 FTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGK--------------- 3600
FTG+F E +LK++A PK Y SD WNVFD L+V+GS ID+ +
Sbjct: 1278 FTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDAL 1337
Query: 3601 -------------------------LNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTL 3705
+N + ISI FFRLFRVMRLVKLLSRGEGIRTL
Sbjct: 1338 IVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTL 1397
Query: 3706 LWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVL 3885
LWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL+D+T I+RNNNF +FP A+L+L
Sbjct: 1398 LWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLL 1457
Query: 3886 FRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFL 4065
FR ATGEAWQDIML+C + +C P S+ + E+ CG++FA YFISF+MLC+FL
Sbjct: 1458 FRCATGEAWQDIMLACMPGK--KCAPESEPSNSTE-GETPCGSSFAVFYFISFYMLCAFL 1514
Query: 4066 VINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+W+EYDP+AKGRIKHLDVVTLLR+I P
Sbjct: 1515 IINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQP 1574
Query: 4246 PLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNIDEANEQLR 4425
PLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFALVRT L+I TEGN+++ANE+LR
Sbjct: 1575 PLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELR 1634
Query: 4426 SAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEMEAKGVLPA 4605
+ IK+IWKRT LLD+VVPPAG +D+VTVGKFYATFLIQ+YFR+FKKRKE G P+
Sbjct: 1635 AIIKKIWKRTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQEYFRKFKKRKEQGLVG-KPS 1692
Query: 4606 QTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDE 4719
Q A++LQAGLRTLH+IGPE++RAISG+L + D+
Sbjct: 1693 QR-NALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDK 1729
Score = 722 bits (1863), Expect = 0.0
Identities = 383/698 (54%), Positives = 459/698 (64%), Gaps = 28/698 (4%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXX-XXXNNPIRKLCISIVEWKPFEFLILFMICANCIA 312
+KR KP +Q + NPIR+ CISIVEWKPFE +IL I ANC+A
Sbjct: 81 RKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVA 140
Query: 313 LAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDF 492
LAIY P+P DS+ N+ LE +EY+F+++FT+E LK++A G +FHP+AYLRN WN+LDF
Sbjct: 141 LAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDF 200
Query: 493 IIVVIGLVSTILSKMSIQ-----------GFDVKALRAFRVLRPLRLVSGVPSLQVVLNA 639
IIVV+GL S IL + + GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+
Sbjct: 201 IIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNS 260
Query: 640 ILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPA--TGQLAQKDPTPCGTDT 813
I++AM+PLLHIALLVLFVI+IYAIIGLELF GK+H TC + A+ DP+PC +T
Sbjct: 261 IIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALET 320
Query: 814 EGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDV 993
G +CQ + ++ G W GP +GITNFDNF AMLTVFQC+++EGWTDV
Sbjct: 321 -GHGRQCQ-NGTVCKPG----------WDGPKHGITNFDNFAFAMLTVFQCITMEGWTDV 368
Query: 994 MYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQ 1173
+YWVNDAVGR+WPWIYFVTL+I+GSFFVLNLVLGVLSGEFSKEREKA+ARG FQK REKQ
Sbjct: 369 LYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 428
Query: 1174 QLEEDLKGYLDWITQAEDIEPVNEDEQEDE--------PVAQTXXXXXXXXXXXXXXXXX 1329
QLEEDLKGYLDWITQAEDI+P NEDE DE P ++T
Sbjct: 429 QLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGEN 488
Query: 1330 XPSKWAARMKRLE------KLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQ 1491
++ A R+ + + + N VKS FYW SEHY Q
Sbjct: 489 CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQ 548
Query: 1492 SEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYF 1671
WL Q AN + LF+ EMLLKMYSLG Y S FNRFDCFVV ILE +LV
Sbjct: 549 PNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+M PLG+SVLR RLLRIFK+T+YW
Sbjct: 609 KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668
Query: 1852 GMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGV 2031
GMQ+FGGKFNF+ Q + R+ FD F Q+LLTVFQILTGEDWN+VMY GI ++GG G+
Sbjct: 669 GMQLFGGKFNFDEMQTR-RSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGM 727
Query: 2032 IVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNA 2145
+VCIY+I+LFICGNYILLNVFLAIAVDNLADA+SLT+A
Sbjct: 728 LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSA 765
Score = 120 bits (301), Expect = 4e-25
Identities = 103/362 (28%), Positives = 164/362 (44%), Gaps = 30/362 (8%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V NN R C IV F LILF I + I+L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 316 AIYQPYPAQDSDYKN----------TLLETIE----------YVFIVVFTIECVLKIVAM 435
A P Q + ++N T + TIE YVF +FT+E +LK+ A
Sbjct: 918 AAEDP--VQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVFTSIFTLEIILKMTAY 975
Query: 436 GFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVP 615
G H ++ RN +NILD ++V + L+S + +I VK LR RVLRPLR ++
Sbjct: 976 GAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINV--VKILRVLRVLRPLRAINRAK 1033
Query: 616 SLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ-KDP 792
L+ V+ + A+ + +I ++ + ++A IG++LF GKL+ TC D + A+ K
Sbjct: 1034 GLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLY-TCSDSSKQTEAECKGN 1092
Query: 793 TPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVS 972
D E QP WE N +FDN AM+ +F +
Sbjct: 1093 YITYKDGEVDHPIIQPRS--------WE-----------NSKFDFDNVLAAMMALFTVST 1133
Query: 973 LEGWTDVMYWVNDAVGREWPWIY---------FVTLVILGSFFVLNLVLGVLSGEFSKER 1125
EGW +++Y D+ + IY F+ +I+ +FF++N+ +G + F ++
Sbjct: 1134 FEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQG 1193
Query: 1126 EK 1131
E+
Sbjct: 1194 EQ 1195
Score = 95.9 bits (237), Expect = 1e-17
Identities = 64/259 (24%), Positives = 124/259 (47%), Gaps = 5/259 (1%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S F +++ ++ +NT+++A +HY + D N +F E +LK+ +L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD VV G ++ + + + I+ R R++R+ K+ +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL--VETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + + S +++ + LL+ L I++++GMQ F GK D+ + R + F +FP ++
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT--RRSTFDNFPQSL 696
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNF----AYPYFISF 4044
L +F+ TGE W +M D G G +F YFI
Sbjct: 697 LTVFQILTGEDWNSVMY--------------DGIMAYG------GPSFPGMLVCIYFIIL 736
Query: 4045 FMLCSFLVINLFVAVIMDN 4101
F+ +++++N+F+A+ +DN
Sbjct: 737 FICGNYILLNVFLAIAVDN 755
Score = 90.9 bits (224), Expect = 3e-16
Identities = 88/353 (24%), Positives = 148/353 (40%), Gaps = 54/353 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE +I L I N V+LA +P S L+ +F +F EA LK++A
Sbjct: 124 KPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGL 183
Query: 3511 -LNPKNYISDRWNVFD-LLVVVGSFIDITYGKLNPGGTNLIS-------INFFRLFRVMR 3663
+P Y+ + WN+ D ++VVVG F I G N + + R FRV+R
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLR 243
Query: 3664 LVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV--------- 3813
++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F GK+
Sbjct: 244 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEG 303
Query: 3814 -----ALDDSTSI------------------------HRNNNFHSFPAAILVLFRSATGE 3906
A DD + H NF +F A+L +F+ T E
Sbjct: 304 IADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITME 363
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVA 4086
W D++ +D G ++ + YF++ ++ SF V+NL +
Sbjct: 364 GWTDVLYWVND---------------------AVGRDWPWIYFVTLIIIGSFFVLNLVLG 402
Query: 4087 VIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
V+ F G + +R + + D KG +LD +T I P
Sbjct: 403 VLSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 449
Score = 89.0 bits (219), Expect = 1e-15
Identities = 77/282 (27%), Positives = 122/282 (42%), Gaps = 29/282 (10%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR--NMILNYF 2502
+L L+ N R C +V F +L I + LA P + + N L
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL----RTDAMS 2670
+Y F +FTVE LKVI +GL+FH ++ RN +NLLD ++V V L S +L + D +
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 2671 XXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
A ++ L+ V+ +I A+ + +I L+ + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 2824 AIIGVQLFKGTFF-LCNDLSKMTE-------AECRGEYIH---YEDGDPTKPVSKKRVW- 2967
AIIG++LF G C + + + + C E H ++G KP W
Sbjct: 283 AIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKP-----GWD 337
Query: 2968 --SNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEED 3087
+ NFDN AM+++F T EGW +LY D+ D
Sbjct: 338 GPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRD 379
Score = 79.7 bits (195), Expect = 7e-13
Identities = 75/343 (21%), Positives = 132/343 (37%), Gaps = 61/343 (17%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+L+ +I N I LA+ Q Y Q +K + + +F +FT+E +LK++A F
Sbjct: 1241 FEYLMFVLILLNTICLAM-QHY-GQSCLFK-IAMNILNMLFTGLFTVEMILKLIA----F 1293
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD------------------------ 555
P Y + WN+ DF+IV+ ++ ILS+ + D
Sbjct: 1294 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNP 1353
Query: 556 -------------------VKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIAL 678
+ R FRV+R ++L+S ++ +L +++ L ++AL
Sbjct: 1354 AEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVAL 1413
Query: 679 LVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTN 858
L++ + IYA+IG+++F G++A D T
Sbjct: 1414 LIVMLFFIYAVIGMQVF-------------GKIALNDTTEI------------------- 1441
Query: 859 MGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWV----------- 1005
N NF F A+L +F+C + E W D+M
Sbjct: 1442 -----------------NRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESE 1484
Query: 1006 -------NDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
G + YF++ +L +F ++NL + V+ F
Sbjct: 1485 PSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1527
Score = 62.4 bits (150), Expect = 1e-07
Identities = 60/268 (22%), Positives = 100/268 (36%), Gaps = 55/268 (20%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HYGQS + N+ F LF++EM+LK+ + Y + +N FD +VI SI++
Sbjct: 1259 QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDV 1318
Query: 1657 VLVY-----------FDLMKPLG-------------------------------VSVLRS 1710
+L FD + +G ++ R
Sbjct: 1319 ILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRL 1378
Query: 1711 ARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNP 1890
R++R+ K+ GMQVFG +
Sbjct: 1379 FRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDT 1438
Query: 1891 QQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGI-------ESFGGVGTLGVIVC--- 2040
+ NF TF QA+L +F+ TGE W +M + ES T G C
Sbjct: 1439 TEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSS 1498
Query: 2041 ---IYYIVLFICGNYILLNVFLAIAVDN 2115
Y+I ++ ++++N+F+A+ +DN
Sbjct: 1499 FAVFYFISFYMLCAFLIINLFVAVIMDN 1526
Score = 42.0 bits (97), Expect = 0.17
Identities = 46/234 (19%), Positives = 86/234 (36%), Gaps = 38/234 (16%)
Frame = +1
Query: 1522 ANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPL 1689
A+ F +F++E++LKM + G ++ + FN D VV S++ F + +
Sbjct: 956 ADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINV-- 1013
Query: 1690 GVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFG 1869
V +LR R+LR + G+Q+F
Sbjct: 1014 -VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFK 1072
Query: 1870 GKFNFNPQQPK------------------------PRA------NFDTFVQALLTVFQIL 1959
GK K PR+ +FD + A++ +F +
Sbjct: 1073 GKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVS 1132
Query: 1960 TGEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
T E W ++Y I+S G + V + I++I+ I + ++N+F+ +
Sbjct: 1133 TFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1186
>gi|508193|emb|CAA84352.1| voltage-dependent L-type Ca channel alpha 1
subunit [Homo sapiens]
Length = 2186
Score = 1005 bits (2599), Expect = 0.0
Identities = 512/878 (58%), Positives = 641/878 (72%), Gaps = 60/878 (6%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPR +SE+ P+P+AS+ FI S N FR+ C+ +VN + FTN +LF IL+SS L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 2446 AAEDPLQANSTRNMILNYFD--------------------YFFTSVFTVEITLKVIVFGL 2565
AAEDP+Q S RN IL YFD Y FTS+FT+EI LK+ +G
Sbjct: 918 AAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVFTSIFTLEIILKMTAYGA 977
Query: 2566 VFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKH 2745
HKGSFCRN FN+LD+LVV+VSL SF +++ A++ AINRAKGLKH
Sbjct: 978 FLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKH 1037
Query: 2746 VVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYE 2925
VVQCV VA++TIGNI++VT +LQFMFA IGVQLFKG + C+D SK TEAEC+G YI Y+
Sbjct: 1038 VVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYK 1097
Query: 2926 DGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHN 3105
DG+ P+ + R W N+ F+FDNV AM++LF VSTFEGWP+LLY +IDS+ EDKGPI+N
Sbjct: 1098 DGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYN 1157
Query: 3106 SRQAVALXXXXXXXXXXXXXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAK 3285
R +++ GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+
Sbjct: 1158 YRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKAR 1217
Query: 3286 PHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLI 3465
P RRYIP+N+ QY+VW+ V S FEY++F++I++NT+ LA +HY S F+ +++ N++
Sbjct: 1218 PLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNML 1277
Query: 3466 FTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGK--------------- 3600
FTG+F E +LK++A PK Y SD WNVFD L+V+GS ID+ +
Sbjct: 1278 FTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDAL 1337
Query: 3601 -------------------------LNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTL 3705
+N + ISI FFRLFRVMRLVKLLSRGEGIRTL
Sbjct: 1338 IVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTL 1397
Query: 3706 LWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVL 3885
LWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL+D+T I+RNNNF +FP A+L+L
Sbjct: 1398 LWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLL 1457
Query: 3886 FRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFL 4065
FR ATGEAWQDIML+C + +C P S+ + E+ CG++FA YFISF+MLC+FL
Sbjct: 1458 FRCATGEAWQDIMLACMPGK--KCAPESEPSNSTE-GETPCGSSFAVFYFISFYMLCAFL 1514
Query: 4066 VINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+W+EYDP+AKGRIKHLDVVTLLR+I P
Sbjct: 1515 IINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQP 1574
Query: 4246 PLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNIDEANEQLR 4425
PLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFALVRT L+I TEGN+++ANE+LR
Sbjct: 1575 PLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELR 1634
Query: 4426 SAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEMEAKGVLPA 4605
+ IK+IWKRT LLD+VVPPAG +D+VTVGKFYATFLIQ+YFR+FKKRKE G P+
Sbjct: 1635 AIIKKIWKRTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQEYFRKFKKRKEQGLVG-KPS 1692
Query: 4606 QTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDE 4719
Q A++LQAGLRTLH+IGPE++RAISG+L + D+
Sbjct: 1693 QR-NALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDK 1729
Score = 722 bits (1863), Expect = 0.0
Identities = 383/698 (54%), Positives = 459/698 (64%), Gaps = 28/698 (4%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXX-XXXNNPIRKLCISIVEWKPFEFLILFMICANCIA 312
+KR KP +Q + NPIR+ CISIVEWKPFE +IL I ANC+A
Sbjct: 81 RKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVA 140
Query: 313 LAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDF 492
LAIY P+P DS+ N+ LE +EY+F+++FT+E LK++A G +FHP+AYLRN WN+LDF
Sbjct: 141 LAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDF 200
Query: 493 IIVVIGLVSTILSKMSIQ-----------GFDVKALRAFRVLRPLRLVSGVPSLQVVLNA 639
IIVV+GL S IL + + GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+
Sbjct: 201 IIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNS 260
Query: 640 ILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPA--TGQLAQKDPTPCGTDT 813
I++AM+PLLHIALLVLFVI+IYAIIGLELF GK+H TC + A+ DP+PC +T
Sbjct: 261 IIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALET 320
Query: 814 EGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDV 993
G +CQ + ++ G W GP +GITNFDNF AMLTVFQC+++EGWTDV
Sbjct: 321 -GHGRQCQ-NGTVCKPG----------WDGPKHGITNFDNFAFAMLTVFQCITMEGWTDV 368
Query: 994 MYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQ 1173
+YWVNDAVGR+WPWIYFVTL+I+GSFFVLNLVLGVLSGEFSKEREKA+ARG FQK REKQ
Sbjct: 369 LYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 428
Query: 1174 QLEEDLKGYLDWITQAEDIEPVNEDEQEDE--------PVAQTXXXXXXXXXXXXXXXXX 1329
QLEEDLKGYLDWITQAEDI+P NEDE DE P ++T
Sbjct: 429 QLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGEN 488
Query: 1330 XPSKWAARMKRLE------KLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQ 1491
++ A R+ + + + N VKS FYW SEHY Q
Sbjct: 489 CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQ 548
Query: 1492 SEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYF 1671
WL Q AN + LF+ EMLLKMYSLG Y S FNRFDCFVV ILE +LV
Sbjct: 549 PNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+M PLG+SVLR RLLRIFK+T+YW
Sbjct: 609 KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668
Query: 1852 GMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGV 2031
GMQ+FGGKFNF+ Q + R+ FD F Q+LLTVFQILTGEDWN+VMY GI ++GG G+
Sbjct: 669 GMQLFGGKFNFDEMQTR-RSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGM 727
Query: 2032 IVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNA 2145
+VCIY+I+LFICGNYILLNVFLAIAVDNLADA+SLT+A
Sbjct: 728 LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSA 765
Score = 120 bits (301), Expect = 4e-25
Identities = 103/362 (28%), Positives = 164/362 (44%), Gaps = 30/362 (8%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V NN R C IV F LILF I + I+L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 316 AIYQPYPAQDSDYKN----------TLLETIE----------YVFIVVFTIECVLKIVAM 435
A P Q + ++N T + TIE YVF +FT+E +LK+ A
Sbjct: 918 AAEDP--VQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVFTSIFTLEIILKMTAY 975
Query: 436 GFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVP 615
G H ++ RN +NILD ++V + L+S + +I VK LR RVLRPLR ++
Sbjct: 976 GAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINV--VKILRVLRVLRPLRAINRAK 1033
Query: 616 SLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ-KDP 792
L+ V+ + A+ + +I ++ + ++A IG++LF GKL+ TC D + A+ K
Sbjct: 1034 GLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLY-TCSDSSKQTEAECKGN 1092
Query: 793 TPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVS 972
D E QP WE N +FDN AM+ +F +
Sbjct: 1093 YITYKDGEVDHPIIQPRS--------WE-----------NSKFDFDNVLAAMMALFTVST 1133
Query: 973 LEGWTDVMYWVNDAVGREWPWIY---------FVTLVILGSFFVLNLVLGVLSGEFSKER 1125
EGW +++Y D+ + IY F+ +I+ +FF++N+ +G + F ++
Sbjct: 1134 FEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQG 1193
Query: 1126 EK 1131
E+
Sbjct: 1194 EQ 1195
Score = 95.9 bits (237), Expect = 1e-17
Identities = 64/259 (24%), Positives = 124/259 (47%), Gaps = 5/259 (1%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S F +++ ++ +NT+++A +HY + D N +F E +LK+ +L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD VV G ++ + + + I+ R R++R+ K+ +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL--VETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + + S +++ + LL+ L I++++GMQ F GK D+ + R + F +FP ++
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT--RRSTFDNFPQSL 696
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNF----AYPYFISF 4044
L +F+ TGE W +M D G G +F YFI
Sbjct: 697 LTVFQILTGEDWNSVMY--------------DGIMAYG------GPSFPGMLVCIYFIIL 736
Query: 4045 FMLCSFLVINLFVAVIMDN 4101
F+ +++++N+F+A+ +DN
Sbjct: 737 FICGNYILLNVFLAIAVDN 755
Score = 90.9 bits (224), Expect = 3e-16
Identities = 88/353 (24%), Positives = 148/353 (40%), Gaps = 54/353 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE +I L I N V+LA +P S L+ +F +F EA LK++A
Sbjct: 124 KPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGL 183
Query: 3511 -LNPKNYISDRWNVFD-LLVVVGSFIDITYGKLNPGGTNLIS-------INFFRLFRVMR 3663
+P Y+ + WN+ D ++VVVG F I G N + + R FRV+R
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLR 243
Query: 3664 LVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV--------- 3813
++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F GK+
Sbjct: 244 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEG 303
Query: 3814 -----ALDDSTSI------------------------HRNNNFHSFPAAILVLFRSATGE 3906
A DD + H NF +F A+L +F+ T E
Sbjct: 304 IADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITME 363
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVA 4086
W D++ +D G ++ + YF++ ++ SF V+NL +
Sbjct: 364 GWTDVLYWVND---------------------AVGRDWPWIYFVTLIIIGSFFVLNLVLG 402
Query: 4087 VIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
V+ F G + +R + + D KG +LD +T I P
Sbjct: 403 VLSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 449
Score = 89.0 bits (219), Expect = 1e-15
Identities = 77/282 (27%), Positives = 122/282 (42%), Gaps = 29/282 (10%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR--NMILNYF 2502
+L L+ N R C +V F +L I + LA P + + N L
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL----RTDAMS 2670
+Y F +FTVE LKVI +GL+FH ++ RN +NLLD ++V V L S +L + D +
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 2671 XXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
A ++ L+ V+ +I A+ + +I L+ + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 2824 AIIGVQLFKGTFF-LCNDLSKMTE-------AECRGEYIH---YEDGDPTKPVSKKRVW- 2967
AIIG++LF G C + + + + C E H ++G KP W
Sbjct: 283 AIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKP-----GWD 337
Query: 2968 --SNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEED 3087
+ NFDN AM+++F T EGW +LY D+ D
Sbjct: 338 GPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRD 379
Score = 79.7 bits (195), Expect = 7e-13
Identities = 75/343 (21%), Positives = 132/343 (37%), Gaps = 61/343 (17%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+L+ +I N I LA+ Q Y Q +K + + +F +FT+E +LK++A F
Sbjct: 1241 FEYLMFVLILLNTICLAM-QHY-GQSCLFK-IAMNILNMLFTGLFTVEMILKLIA----F 1293
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD------------------------ 555
P Y + WN+ DF+IV+ ++ ILS+ + D
Sbjct: 1294 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNP 1353
Query: 556 -------------------VKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIAL 678
+ R FRV+R ++L+S ++ +L +++ L ++AL
Sbjct: 1354 AEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVAL 1413
Query: 679 LVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTN 858
L++ + IYA+IG+++F G++A D T
Sbjct: 1414 LIVMLFFIYAVIGMQVF-------------GKIALNDTTEI------------------- 1441
Query: 859 MGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWV----------- 1005
N NF F A+L +F+C + E W D+M
Sbjct: 1442 -----------------NRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESE 1484
Query: 1006 -------NDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
G + YF++ +L +F ++NL + V+ F
Sbjct: 1485 PSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1527
Score = 62.4 bits (150), Expect = 1e-07
Identities = 60/268 (22%), Positives = 100/268 (36%), Gaps = 55/268 (20%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HYGQS + N+ F LF++EM+LK+ + Y + +N FD +VI SI++
Sbjct: 1259 QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDV 1318
Query: 1657 VLVY-----------FDLMKPLG-------------------------------VSVLRS 1710
+L FD + +G ++ R
Sbjct: 1319 ILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRL 1378
Query: 1711 ARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNP 1890
R++R+ K+ GMQVFG +
Sbjct: 1379 FRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDT 1438
Query: 1891 QQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGI-------ESFGGVGTLGVIVC--- 2040
+ NF TF QA+L +F+ TGE W +M + ES T G C
Sbjct: 1439 TEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSS 1498
Query: 2041 ---IYYIVLFICGNYILLNVFLAIAVDN 2115
Y+I ++ ++++N+F+A+ +DN
Sbjct: 1499 FAVFYFISFYMLCAFLIINLFVAVIMDN 1526
Score = 42.0 bits (97), Expect = 0.17
Identities = 46/234 (19%), Positives = 86/234 (36%), Gaps = 38/234 (16%)
Frame = +1
Query: 1522 ANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPL 1689
A+ F +F++E++LKM + G ++ + FN D VV S++ F + +
Sbjct: 956 ADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINV-- 1013
Query: 1690 GVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFG 1869
V +LR R+LR + G+Q+F
Sbjct: 1014 -VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFK 1072
Query: 1870 GKFNFNPQQPK------------------------PRA------NFDTFVQALLTVFQIL 1959
GK K PR+ +FD + A++ +F +
Sbjct: 1073 GKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVS 1132
Query: 1960 TGEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
T E W ++Y I+S G + V + I++I+ I + ++N+F+ +
Sbjct: 1133 TFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1186
>gi|284018|pir||A45290 calcium channel protein type L - human
Length = 2220
Score = 1005 bits (2599), Expect = 0.0
Identities = 512/878 (58%), Positives = 641/878 (72%), Gaps = 60/878 (6%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPR +SE+ P+P+AS+ FI S N FR+ C+ +VN + FTN +LF IL+SS L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 2446 AAEDPLQANSTRNMILNYFD--------------------YFFTSVFTVEITLKVIVFGL 2565
AAEDP+Q S RN IL YFD Y FTS+FT+EI LK+ +G
Sbjct: 918 AAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVFTSIFTLEIILKMTAYGA 977
Query: 2566 VFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKH 2745
HKGSFCRN FN+LD+LVV+VSL SF +++ A++ AINRAKGLKH
Sbjct: 978 FLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKH 1037
Query: 2746 VVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYE 2925
VVQCV VA++TIGNI++VT +LQFMFA IGVQLFKG + C+D SK TEAEC+G YI Y+
Sbjct: 1038 VVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYK 1097
Query: 2926 DGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHN 3105
DG+ P+ + R W N+ F+FDNV AM++LF VSTFEGWP+LLY +IDS+ EDKGPI+N
Sbjct: 1098 DGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYN 1157
Query: 3106 SRQAVALXXXXXXXXXXXXXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAK 3285
R +++ GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+
Sbjct: 1158 YRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKAR 1217
Query: 3286 PHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLI 3465
P RRYIP+N+ QY+VW+ V S FEY++F++I++NT+ LA +HY S F+ +++ N++
Sbjct: 1218 PLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNML 1277
Query: 3466 FTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGK--------------- 3600
FTG+F E +LK++A PK Y SD WNVFD L+V+GS ID+ +
Sbjct: 1278 FTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDAL 1337
Query: 3601 -------------------------LNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTL 3705
+N + ISI FFRLFRVMRLVKLLSRGEGIRTL
Sbjct: 1338 IVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTL 1397
Query: 3706 LWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVL 3885
LWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL+D+T I+RNNNF +FP A+L+L
Sbjct: 1398 LWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLL 1457
Query: 3886 FRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFL 4065
FR ATGEAWQDIML+C + +C P S+ + E+ CG++FA YFISF+MLC+FL
Sbjct: 1458 FRCATGEAWQDIMLACMPGK--KCAPESEPSNSTE-GETPCGSSFAVFYFISFYMLCAFL 1514
Query: 4066 VINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+W+EYDP+AKGRIKHLDVVTLLR+I P
Sbjct: 1515 IINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQP 1574
Query: 4246 PLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNIDEANEQLR 4425
PLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFALVRT L+I TEGN+++ANE+LR
Sbjct: 1575 PLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELR 1634
Query: 4426 SAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEMEAKGVLPA 4605
+ IK+IWKRT LLD+VVPPAG +D+VTVGKFYATFLIQ+YFR+FKKRKE G P+
Sbjct: 1635 AIIKKIWKRTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQEYFRKFKKRKEQGLVG-KPS 1692
Query: 4606 QTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDE 4719
Q A++LQAGLRTLH+IGPE++RAISG+L + D+
Sbjct: 1693 QR-NALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDK 1729
Score = 722 bits (1863), Expect = 0.0
Identities = 383/698 (54%), Positives = 459/698 (64%), Gaps = 28/698 (4%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXX-XXXNNPIRKLCISIVEWKPFEFLILFMICANCIA 312
+KR KP +Q + NPIR+ CISIVEWKPFE +IL I ANC+A
Sbjct: 81 RKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVA 140
Query: 313 LAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDF 492
LAIY P+P DS+ N+ LE +EY+F+++FT+E LK++A G +FHP+AYLRN WN+LDF
Sbjct: 141 LAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDF 200
Query: 493 IIVVIGLVSTILSKMSIQ-----------GFDVKALRAFRVLRPLRLVSGVPSLQVVLNA 639
IIVV+GL S IL + + GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+
Sbjct: 201 IIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNS 260
Query: 640 ILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPA--TGQLAQKDPTPCGTDT 813
I++AM+PLLHIALLVLFVI+IYAIIGLELF GK+H TC + A+ DP+PC +T
Sbjct: 261 IIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALET 320
Query: 814 EGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDV 993
G +CQ + ++ G W GP +GITNFDNF AMLTVFQC+++EGWTDV
Sbjct: 321 -GHGRQCQ-NGTVCKPG----------WDGPKHGITNFDNFAFAMLTVFQCITMEGWTDV 368
Query: 994 MYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQ 1173
+YWVNDAVGR+WPWIYFVTL+I+GSFFVLNLVLGVLSGEFSKEREKA+ARG FQK REKQ
Sbjct: 369 LYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 428
Query: 1174 QLEEDLKGYLDWITQAEDIEPVNEDEQEDE--------PVAQTXXXXXXXXXXXXXXXXX 1329
QLEEDLKGYLDWITQAEDI+P NEDE DE P ++T
Sbjct: 429 QLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGEN 488
Query: 1330 XPSKWAARMKRLE------KLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQ 1491
++ A R+ + + + N VKS FYW SEHY Q
Sbjct: 489 CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQ 548
Query: 1492 SEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYF 1671
WL Q AN + LF+ EMLLKMYSLG Y S FNRFDCFVV ILE +LV
Sbjct: 549 PNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+M PLG+SVLR RLLRIFK+T+YW
Sbjct: 609 KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668
Query: 1852 GMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGV 2031
GMQ+FGGKFNF+ Q + R+ FD F Q+LLTVFQILTGEDWN+VMY GI ++GG G+
Sbjct: 669 GMQLFGGKFNFDEMQTR-RSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGM 727
Query: 2032 IVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNA 2145
+VCIY+I+LFICGNYILLNVFLAIAVDNLADA+SLT+A
Sbjct: 728 LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSA 765
Score = 120 bits (301), Expect = 4e-25
Identities = 103/362 (28%), Positives = 164/362 (44%), Gaps = 30/362 (8%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V NN R C IV F LILF I + I+L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 316 AIYQPYPAQDSDYKN----------TLLETIE----------YVFIVVFTIECVLKIVAM 435
A P Q + ++N T + TIE YVF +FT+E +LK+ A
Sbjct: 918 AAEDP--VQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVFTSIFTLEIILKMTAY 975
Query: 436 GFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVP 615
G H ++ RN +NILD ++V + L+S + +I VK LR RVLRPLR ++
Sbjct: 976 GAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINV--VKILRVLRVLRPLRAINRAK 1033
Query: 616 SLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ-KDP 792
L+ V+ + A+ + +I ++ + ++A IG++LF GKL+ TC D + A+ K
Sbjct: 1034 GLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLY-TCSDSSKQTEAECKGN 1092
Query: 793 TPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVS 972
D E QP WE N +FDN AM+ +F +
Sbjct: 1093 YITYKDGEVDHPIIQPRS--------WE-----------NSKFDFDNVLAAMMALFTVST 1133
Query: 973 LEGWTDVMYWVNDAVGREWPWIY---------FVTLVILGSFFVLNLVLGVLSGEFSKER 1125
EGW +++Y D+ + IY F+ +I+ +FF++N+ +G + F ++
Sbjct: 1134 FEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQG 1193
Query: 1126 EK 1131
E+
Sbjct: 1194 EQ 1195
Score = 95.9 bits (237), Expect = 1e-17
Identities = 64/259 (24%), Positives = 124/259 (47%), Gaps = 5/259 (1%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S F +++ ++ +NT+++A +HY + D N +F E +LK+ +L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD VV G ++ + + + I+ R R++R+ K+ +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL--VETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + + S +++ + LL+ L I++++GMQ F GK D+ + R + F +FP ++
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT--RRSTFDNFPQSL 696
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNF----AYPYFISF 4044
L +F+ TGE W +M D G G +F YFI
Sbjct: 697 LTVFQILTGEDWNSVMY--------------DGIMAYG------GPSFPGMLVCIYFIIL 736
Query: 4045 FMLCSFLVINLFVAVIMDN 4101
F+ +++++N+F+A+ +DN
Sbjct: 737 FICGNYILLNVFLAIAVDN 755
Score = 90.9 bits (224), Expect = 3e-16
Identities = 88/353 (24%), Positives = 148/353 (40%), Gaps = 54/353 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE +I L I N V+LA +P S L+ +F +F EA LK++A
Sbjct: 124 KPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGL 183
Query: 3511 -LNPKNYISDRWNVFD-LLVVVGSFIDITYGKLNPGGTNLIS-------INFFRLFRVMR 3663
+P Y+ + WN+ D ++VVVG F I G N + + R FRV+R
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLR 243
Query: 3664 LVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV--------- 3813
++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F GK+
Sbjct: 244 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEG 303
Query: 3814 -----ALDDSTSI------------------------HRNNNFHSFPAAILVLFRSATGE 3906
A DD + H NF +F A+L +F+ T E
Sbjct: 304 IADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITME 363
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVA 4086
W D++ +D G ++ + YF++ ++ SF V+NL +
Sbjct: 364 GWTDVLYWVND---------------------AVGRDWPWIYFVTLIIIGSFFVLNLVLG 402
Query: 4087 VIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
V+ F G + +R + + D KG +LD +T I P
Sbjct: 403 VLSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 449
Score = 89.0 bits (219), Expect = 1e-15
Identities = 77/282 (27%), Positives = 122/282 (42%), Gaps = 29/282 (10%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR--NMILNYF 2502
+L L+ N R C +V F +L I + LA P + + N L
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL----RTDAMS 2670
+Y F +FTVE LKVI +GL+FH ++ RN +NLLD ++V V L S +L + D +
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 2671 XXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
A ++ L+ V+ +I A+ + +I L+ + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 2824 AIIGVQLFKGTFF-LCNDLSKMTE-------AECRGEYIH---YEDGDPTKPVSKKRVW- 2967
AIIG++LF G C + + + + C E H ++G KP W
Sbjct: 283 AIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKP-----GWD 337
Query: 2968 --SNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEED 3087
+ NFDN AM+++F T EGW +LY D+ D
Sbjct: 338 GPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRD 379
Score = 79.7 bits (195), Expect = 7e-13
Identities = 75/343 (21%), Positives = 132/343 (37%), Gaps = 61/343 (17%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+L+ +I N I LA+ Q Y Q +K + + +F +FT+E +LK++A F
Sbjct: 1241 FEYLMFVLILLNTICLAM-QHY-GQSCLFK-IAMNILNMLFTGLFTVEMILKLIA----F 1293
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD------------------------ 555
P Y + WN+ DF+IV+ ++ ILS+ + D
Sbjct: 1294 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNP 1353
Query: 556 -------------------VKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIAL 678
+ R FRV+R ++L+S ++ +L +++ L ++AL
Sbjct: 1354 AEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVAL 1413
Query: 679 LVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTN 858
L++ + IYA+IG+++F G++A D T
Sbjct: 1414 LIVMLFFIYAVIGMQVF-------------GKIALNDTTEI------------------- 1441
Query: 859 MGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWV----------- 1005
N NF F A+L +F+C + E W D+M
Sbjct: 1442 -----------------NRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESE 1484
Query: 1006 -------NDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
G + YF++ +L +F ++NL + V+ F
Sbjct: 1485 PSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1527
Score = 62.4 bits (150), Expect = 1e-07
Identities = 60/268 (22%), Positives = 100/268 (36%), Gaps = 55/268 (20%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HYGQS + N+ F LF++EM+LK+ + Y + +N FD +VI SI++
Sbjct: 1259 QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDV 1318
Query: 1657 VLVY-----------FDLMKPLG-------------------------------VSVLRS 1710
+L FD + +G ++ R
Sbjct: 1319 ILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRL 1378
Query: 1711 ARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNP 1890
R++R+ K+ GMQVFG +
Sbjct: 1379 FRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDT 1438
Query: 1891 QQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGI-------ESFGGVGTLGVIVC--- 2040
+ NF TF QA+L +F+ TGE W +M + ES T G C
Sbjct: 1439 TEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSS 1498
Query: 2041 ---IYYIVLFICGNYILLNVFLAIAVDN 2115
Y+I ++ ++++N+F+A+ +DN
Sbjct: 1499 FAVFYFISFYMLCAFLIINLFVAVIMDN 1526
Score = 42.0 bits (97), Expect = 0.17
Identities = 46/234 (19%), Positives = 86/234 (36%), Gaps = 38/234 (16%)
Frame = +1
Query: 1522 ANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPL 1689
A+ F +F++E++LKM + G ++ + FN D VV S++ F + +
Sbjct: 956 ADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINV-- 1013
Query: 1690 GVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFG 1869
V +LR R+LR + G+Q+F
Sbjct: 1014 -VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFK 1072
Query: 1870 GKFNFNPQQPK------------------------PRA------NFDTFVQALLTVFQIL 1959
GK K PR+ +FD + A++ +F +
Sbjct: 1073 GKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVS 1132
Query: 1960 TGEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
T E W ++Y I+S G + V + I++I+ I + ++N+F+ +
Sbjct: 1133 TFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1186
>gi|4138822|gb|AAD03587.1| voltage-gated L-type calcium channel
alpha-1 subunit [Homo sapiens]
Length = 1912
Score = 1005 bits (2598), Expect = 0.0
Identities = 503/819 (61%), Positives = 625/819 (75%), Gaps = 10/819 (1%)
Frame = +1
Query: 2278 MSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAED 2457
+ EV V PIP+ S+ F LS TN R C+ +++H FTN +L I++SS LAAED
Sbjct: 768 LQEVVPKEKVVPIPEGSAFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAED 827
Query: 2458 PLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSL 2637
P++A+S RN IL YFDY FTS+FTVEI LK+ VFG H+GSFCR+ FN+LD+LVV+VSL
Sbjct: 828 PIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSL 887
Query: 2638 TSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQF 2817
SF + + A+S AINRAKGLKHVVQCV VA++TIGNIM+VT +LQF
Sbjct: 888 ISFGIHSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQF 947
Query: 2818 MFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNV 2997
MFA IGVQLFKG F+ C D +K T EC+G ++ Y DGD ++P+ ++R+W N+DFNFDNV
Sbjct: 948 MFACIGVQLFKGKFYTCTDEAKHTPQECKGSFLVYPDGDVSRPLVRERLWVNSDFNFDNV 1007
Query: 2998 GDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXX 3177
AM++LF VSTFEGWP LLY AID+ ED GPI+N R +++
Sbjct: 1008 LSAMMALFTVSTFEGWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIF 1067
Query: 3178 XGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVTSRAF 3357
GFVI+TF+ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N QYRVW V S AF
Sbjct: 1068 VGFVIITFRAQGEQEYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWATVNSAAF 1127
Query: 3358 EYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISD 3537
EY++FL+I++NTV+LA +HY + F +D+ N++FTG+F E VLKI+A PK+Y +D
Sbjct: 1128 EYLMFLLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFTD 1187
Query: 3538 RWNVFDLLVVVGSFIDITYGKLNPGG--------TNLISINFFRLFRVMRLVKLLSRGEG 3693
WN FD L+VVGS +DI ++N GG ++ ISI FFRLFRVMRLVKLLS+GEG
Sbjct: 1188 AWNTFDALIVVGSIVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLLSKGEG 1247
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAA 3873
IRTLLWTF+KSFQALPYVALLI ++FFIYAVIGMQ FGKVAL D T I+RNNNF +FP A
Sbjct: 1248 IRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQA 1307
Query: 3874 ILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFML 4053
+L+LFR ATGEAWQ+IML+ RCDP SD G E CG+NFA YFISFFML
Sbjct: 1308 VLLLFRCATGEAWQEIMLASLPGN--RCDPESDF---GPGEEFTCGSNFAIAYFISFFML 1362
Query: 4054 CSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLR 4233
C+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+WSEYDP AKGRIKHLDVV LLR
Sbjct: 1363 CAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLR 1422
Query: 4234 KISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNIDEAN 4413
+I PPLGFGKLCPHR+ACKRLV+MNMPLNSDGTV FNATLFALVRT+LKI TEGN+++AN
Sbjct: 1423 RIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVTFNATLFALVRTSLKIKTEGNLEQAN 1482
Query: 4414 EQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEMEAKG 4593
++LR IK+IWKR + LLDEV+PP E++VTVGKFYATFLIQDYFR+F++RKE KG
Sbjct: 1483 QELRIVIKKIWKRMKQKLLDEVIPPP-DEEEVTVGKFYATFLIQDYFRKFRRRKE---KG 1538
Query: 4594 VL--PAQTPQAMALQAGLRTLHEIGPELKRAISGNLETD 4704
+L A + ALQAGLR+L ++GPE+++A++ + E +
Sbjct: 1539 LLGNDAAPSTSSALQAGLRSLQDLGPEMRQALTCDTEEE 1577
Score = 436 bits (1122), Expect = e-120
Identities = 221/357 (61%), Positives = 268/357 (74%), Gaps = 12/357 (3%)
Frame = +1
Query: 229 IRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTI 408
++ L SIVEWKPF+ LIL I ANC+AL +Y P+P DS+ N LE +EYVF+V+FT+
Sbjct: 16 LQTLGASIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTV 75
Query: 409 ECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQ------------GF 552
E VLKIVA G + HPSAY+RN WN+LDFIIVV+GL S +L + + GF
Sbjct: 76 ETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGF 135
Query: 553 DVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFC 732
DVKALRAFRVLRPLRLVSGVPSL +VLN+I++A++PLLHIALLVLFVI+IYAIIGLELF
Sbjct: 136 DVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFL 195
Query: 733 GKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNN 912
G++H TC + A++DP+PC + G A + EC WPGPN
Sbjct: 196 GRMHKTCYFLGSDMEAEEDPSPCASSGSGRACTLNQT----------ECRGR--WPGPNG 243
Query: 913 GITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVL 1092
GITNFDNF AMLTVFQCV++EGWTDV+YW+ DA+G E PW+YFV+LVI GSFFVLNLVL
Sbjct: 244 GITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVL 303
Query: 1093 GVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDE 1263
GVLSGEFSKEREKA+ARG FQK REKQQ+EEDL+GYLDWITQAE+++ ED D+
Sbjct: 304 GVLSGEFSKEREKAKARGDFQKQREKQQMEEDLRGYLDWITQAEELD--MEDPSADD 358
Score = 246 bits (628), Expect = 5e-63
Identities = 131/261 (50%), Positives = 154/261 (58%)
Frame = +1
Query: 1357 KRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFF 1536
+RL + N VKS YW SEH+GQ WL Q AN
Sbjct: 444 RRLRRANRVLRARCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVL 503
Query: 1537 VILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSAR 1716
+ LF++EMLLK+Y LG + Y +S FNRFDCFVV ILE LV M+PLG+SVLR R
Sbjct: 504 LCLFTVEMLLKLYGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVR 563
Query: 1717 LLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQ 1896
LLRIFKVT++W GMQ+FGGKFNF+
Sbjct: 564 LLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTH 623
Query: 1897 PKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNY 2076
K R+ FDTF QALLTVFQILTGEDWN VMY GI ++GG G++VCIY+I+LFICGNY
Sbjct: 624 TK-RSTFDTFPQALLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNY 682
Query: 2077 ILLNVFLAIAVDNLADADSLT 2139
ILLNVFLAIAVDNLA D+ T
Sbjct: 683 ILLNVFLAIAVDNLASGDAGT 703
Score = 172 bits (437), Expect = 6e-41
Identities = 161/664 (24%), Positives = 282/664 (42%), Gaps = 33/664 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+RK C +++ F LIL I + ++LA P A ++N +L +Y F +F
Sbjct: 793 NPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAHS--FRNHILGYFDYAFTSIF 850
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
T+E +LK+ G H ++ R+ +N+LD ++V + L+S + +I VK LR RV
Sbjct: 851 TVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSSAIS--VVKILRVLRV 908
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLR ++ L+ V+ + A+ + +I ++ + ++A IG++LF GK + TC D
Sbjct: 909 LRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFY-TCTDE 967
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
A+ P C +GS F P ++ VR N+ + NFDN
Sbjct: 968 -----AKHTPQEC----KGS-FLVYPDGDVSRPLVRERLWVNSDF--------NFDNVLS 1009
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIY---------FVTLVILGSFFVLNLVLG 1095
AM+ +F + EGW ++Y DA + IY F+ +I+ +FF++N+ +G
Sbjct: 1010 AMMALFTVSTFEGWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVG 1069
Query: 1096 VLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIE---PVNEDEQEDEP 1266
+ F RA+G ++ + +L+++ + +++ +A+ + P N +
Sbjct: 1070 FVIITF-------RAQG--EQEYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYR--- 1117
Query: 1267 VAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXX 1446
WA V S F +
Sbjct: 1118 ------------------------VWAT-------------------VNSAAFEYLMFLL 1134
Query: 1447 XXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDC 1626
+HY Q+ ++ + N+ F LF++EM+LK+ + Y T +N FD
Sbjct: 1135 ILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDA 1194
Query: 1627 FVVISSILEFVLVYFDLMKPLG----------VSVLRSARLLRIFKVTKYWTXXXXXXXX 1776
+V+ SI++ + + LG ++ R R++R+ K+
Sbjct: 1195 LIVVGSIVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWT 1254
Query: 1777 XXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQI 1956
GMQ+FG + Q NF TF QA+L +F+
Sbjct: 1255 FIKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRC 1314
Query: 1957 LTGEDWNTVMYHGI-------ESFGGVG---TLGVIVCI-YYIVLFICGNYILLNVFLAI 2103
TGE W +M + ES G G T G I Y+I F+ ++++N+F+A+
Sbjct: 1315 ATGEAWQEIMLASLPGNRCDPESDFGPGEEFTCGSNFAIAYFISFFMLCAFLIINLFVAV 1374
Query: 2104 AVDN 2115
+DN
Sbjct: 1375 IMDN 1378
Score = 110 bits (276), Expect = 3e-22
Identities = 78/301 (25%), Positives = 143/301 (46%), Gaps = 1/301 (0%)
Frame = +1
Query: 3202 QNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR-LQYRVWWFVTSRAFEYVIFLI 3378
+ +G+ + E L R C+ +K + RR NR L+ R V S A + + L+
Sbjct: 415 ETQGDEDEEEGALASCTR-CLNKIMKTRVCRRLRRANRVLRARCRRAVKSNACYWAVLLL 473
Query: 3379 IVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDL 3558
+ +NT+++A +H+ + N + +F E +LK+ L P Y+S +N FD
Sbjct: 474 VFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKLYGLGPSAYVSSFFNRFDC 533
Query: 3559 LVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQAL 3738
VV G ++ T ++ G + I+ R R++R+ K+ + L+ + + S +++
Sbjct: 534 FVVCGGILETTLVEV--GAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKSI 591
Query: 3739 PYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQD 3918
+ LL+ L I++++GMQ FG D T R + F +FP A+L +F+ TGE W
Sbjct: 592 ASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKR-STFDTFPQALLTVFQILTGEDWNV 650
Query: 3919 IMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMD 4098
+M + G L YFI F+ +++++N+F+A+ +D
Sbjct: 651 VMYD-------GIMAYGGPFFPGML---------VCIYFIILFICGNYILLNVFLAIAVD 694
Query: 4099 N 4101
N
Sbjct: 695 N 695
Score = 89.7 bits (221), Expect = 7e-16
Identities = 140/693 (20%), Positives = 250/693 (35%), Gaps = 63/693 (9%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIY---QP-YPAQDSDYKNTLLETIEYV 387
N +R C V+ + +L ++ N + +A QP + Q +Y N +L
Sbjct: 450 NRVLRARCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVL------ 503
Query: 388 FIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKM-SIQGFDVKA 564
+ +FT+E +LK+ +G PSAY+ + +N D +V G++ T L ++ ++Q +
Sbjct: 504 -LCLFTVEMLLKLYGLG----PSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISV 558
Query: 565 LRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLH 744
LR R+LR ++ SL ++ ++L +M IA L+L + L I L
Sbjct: 559 LRCVRLLRIFKVTRHWASLSNLVASLLNSM---KSIASLLLLLFLFIIIFSL-------- 607
Query: 745 STCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITN 924
G G F + + +
Sbjct: 608 ------------------LGMQLFGGKFNFDQTHTKRS---------------------T 628
Query: 925 FDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREW-----PWIYFVTLVILGSFFVLNLV 1089
FD F A+LTVFQ ++ E W VMY A G + IYF+ L I G++ +LN+
Sbjct: 629 FDTFPQALLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVF 688
Query: 1090 LGV-----LSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAED--------- 1227
L + SG+ ++K +K EK L ++ +G + + + E+
Sbjct: 689 LAIAVDNLASGDAGTAKDKGG-----EKSNEK-DLPQENEGLVPGVEKEEEEGARREGAD 742
Query: 1228 -IEPVNEDEQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXX 1404
E E+E+E+E + P + L + N
Sbjct: 743 MEEEEEEEEEEEEEEEEEGAGGVELLQEVVPKEKVVPIPEGSAFFCLSQTNPLRKGCHTL 802
Query: 1405 LVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLG 1584
+ + + +H + F +F++E+LLKM G
Sbjct: 803 IHHHVFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFG 862
Query: 1585 F----TTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWT 1752
++ S FN D VV S++ F + + V +LR R+LR +
Sbjct: 863 AFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSSAISV---VKILRVLRVLRPLRAINRAK 919
Query: 1753 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF-------NFNPQQPK--- 1902
G+Q+F GKF PQ+ K
Sbjct: 920 GLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYTCTDEAKHTPQECKGSF 979
Query: 1903 --------------------PRANFDTFVQALLTVFQILTGEDWNTVMYHGIESF----G 2010
NFD + A++ +F + T E W ++Y I+++ G
Sbjct: 980 LVYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDAYAEDHG 1039
Query: 2011 GVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+ V + +++IV I + ++N+F+ +
Sbjct: 1040 PIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVI 1072
Score = 82.4 bits (202), Expect = 1e-13
Identities = 78/310 (25%), Positives = 123/310 (39%), Gaps = 58/310 (18%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ F+ +I L I N V+L +P S L+ +F +F E VLKIVA
Sbjct: 27 KPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGL 86
Query: 3511 -LNPKNYISDRWNVFDLLVVVGSFIDI--------------TYGKLNPGGTNLISINFFR 3645
L+P YI + WN+ D ++VV + T GK PGG + R
Sbjct: 87 VLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGK--PGG---FDVKALR 141
Query: 3646 LFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF------- 3804
FRV+R ++L+S + +L + MK+ L ++ALL++ + IYA+IG++ F
Sbjct: 142 AFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKT 201
Query: 3805 ----------------------GKVALDDSTSIHRN--------NNFHSFPAAILVLFRS 3894
G+ + T NF +F A+L +F+
Sbjct: 202 CYFLGSDMEAEEDPSPCASSGSGRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQC 261
Query: 3895 ATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVIN 4074
T E W D++ D G + YF+S + SF V+N
Sbjct: 262 VTMEGWTDVLYWMQD---------------------AMGYELPWVYFVSLVIFGSFFVLN 300
Query: 4075 LFVAVIMDNF 4104
L + V+ F
Sbjct: 301 LVLGVLSGEF 310
Score = 79.3 bits (194), Expect = 1e-12
Identities = 69/258 (26%), Positives = 103/258 (39%), Gaps = 31/258 (12%)
Frame = +1
Query: 2380 VVNHSYFTNAVLFCILVSSAMLAAEDPLQAN--STRNMILNYFDYFFTSVFTVEITLKVI 2553
+V F +L I + L P + +T N L +Y F +FTVE LK++
Sbjct: 23 IVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIV 82
Query: 2554 VFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL-----------RTDAMSXXXXXXXXXX 2700
+GLV H ++ RN +NLLD ++V V L S +L T
Sbjct: 83 AYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRA 142
Query: 2701 XXXXXAINRAKG---LKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFF-LC 2868
+ G L V+ ++ A+ + +I L+ + ++AIIG++LF G C
Sbjct: 143 FRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTC 202
Query: 2869 NDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNND--------------FNFDNVGDA 3006
L EAE ED P R + N NFDN A
Sbjct: 203 YFLGSDMEAE--------EDPSPCASSGSGRACTLNQTECRGRWPGPNGGITNFDNFFFA 254
Query: 3007 MISLFVVSTFEGWPQLLY 3060
M+++F T EGW +LY
Sbjct: 255 MLTVFQCVTMEGWTDVLY 272
Score = 44.7 bits (104), Expect = 0.027
Identities = 23/64 (35%), Positives = 37/64 (56%)
Frame = +1
Query: 1912 NFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNV 2091
NFD F A+LTVFQ +T E W V+Y ++ G + +Y++ L I G++ +LN+
Sbjct: 247 NFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMG-----YELPWVYFVSLVIFGSFFVLNL 301
Query: 2092 FLAI 2103
L +
Sbjct: 302 VLGV 305
>gi|6525019|gb|AAF15290.1| voltage-gated L-type calcium channel
alpha-1 subunit [Homo sapiens]
Length = 1977
Score = 1005 bits (2598), Expect = 0.0
Identities = 503/819 (61%), Positives = 625/819 (75%), Gaps = 10/819 (1%)
Frame = +1
Query: 2278 MSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAED 2457
+ EV V PIP+ S+ F LS TN R C+ +++H FTN +L I++SS LAAED
Sbjct: 833 LQEVVPKEKVVPIPEGSAFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAED 892
Query: 2458 PLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSL 2637
P++A+S RN IL YFDY FTS+FTVEI LK+ VFG H+GSFCR+ FN+LD+LVV+VSL
Sbjct: 893 PIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSL 952
Query: 2638 TSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQF 2817
SF + + A+S AINRAKGLKHVVQCV VA++TIGNIM+VT +LQF
Sbjct: 953 ISFGIHSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQF 1012
Query: 2818 MFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNV 2997
MFA IGVQLFKG F+ C D +K T EC+G ++ Y DGD ++P+ ++R+W N+DFNFDNV
Sbjct: 1013 MFACIGVQLFKGKFYTCTDEAKHTPQECKGSFLVYPDGDVSRPLVRERLWVNSDFNFDNV 1072
Query: 2998 GDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXX 3177
AM++LF VSTFEGWP LLY AID+ ED GPI+N R +++
Sbjct: 1073 LSAMMALFTVSTFEGWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIF 1132
Query: 3178 XGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVTSRAF 3357
GFVI+TF+ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N QYRVW V S AF
Sbjct: 1133 VGFVIITFRAQGEQEYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWATVNSAAF 1192
Query: 3358 EYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISD 3537
EY++FL+I++NTV+LA +HY + F +D+ N++FTG+F E VLKI+A PK+Y +D
Sbjct: 1193 EYLMFLLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFTD 1252
Query: 3538 RWNVFDLLVVVGSFIDITYGKLNPGG--------TNLISINFFRLFRVMRLVKLLSRGEG 3693
WN FD L+VVGS +DI ++N GG ++ ISI FFRLFRVMRLVKLLS+GEG
Sbjct: 1253 AWNTFDALIVVGSIVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLLSKGEG 1312
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAA 3873
IRTLLWTF+KSFQALPYVALLI ++FFIYAVIGMQ FGKVAL D T I+RNNNF +FP A
Sbjct: 1313 IRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQA 1372
Query: 3874 ILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFML 4053
+L+LFR ATGEAWQ+IML+ RCDP SD G E CG+NFA YFISFFML
Sbjct: 1373 VLLLFRCATGEAWQEIMLASLPGN--RCDPESDF---GPGEEFTCGSNFAIAYFISFFML 1427
Query: 4054 CSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLR 4233
C+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+WSEYDP AKGRIKHLDVV LLR
Sbjct: 1428 CAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLR 1487
Query: 4234 KISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNIDEAN 4413
+I PPLGFGKLCPHR+ACKRLV+MNMPLNSDGTV FNATLFALVRT+LKI TEGN+++AN
Sbjct: 1488 RIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVTFNATLFALVRTSLKIKTEGNLEQAN 1547
Query: 4414 EQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEMEAKG 4593
++LR IK+IWKR + LLDEV+PP E++VTVGKFYATFLIQDYFR+F++RKE KG
Sbjct: 1548 QELRIVIKKIWKRMKQKLLDEVIPPP-DEEEVTVGKFYATFLIQDYFRKFRRRKE---KG 1603
Query: 4594 VL--PAQTPQAMALQAGLRTLHEIGPELKRAISGNLETD 4704
+L A + ALQAGLR+L ++GPE+++A++ + E +
Sbjct: 1604 LLGNDAAPSTSSALQAGLRSLQDLGPEMRQALTCDTEEE 1642
Score = 448 bits (1153), Expect = e-124
Identities = 225/359 (62%), Positives = 272/359 (75%), Gaps = 12/359 (3%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+R+ CISIVEWKPF+ LIL I ANC+AL +Y P+P DS+ N LE +EYVF+V+F
Sbjct: 79 NPLRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIF 138
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQ------------ 546
T+E VLKIVA G + HPSAY+RN WN+LDFIIVV+GL S +L + +
Sbjct: 139 TVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPG 198
Query: 547 GFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLEL 726
GFDVKALRAFRVLRPLRLVSGVPSL +VLN+I++A++PLLHIALLVLFVI+IYAIIGLEL
Sbjct: 199 GFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLEL 258
Query: 727 FCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGP 906
F G++H TC + A++DP+PC + G A + EC WPGP
Sbjct: 259 FLGRMHKTCYFLGSDMEAEEDPSPCASSGSGRACTLNQT----------ECRGR--WPGP 306
Query: 907 NNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNL 1086
N GITNFDNF AMLTVFQCV++EGWTDV+YW+ DA+G E PW+YFV+LVI GSFFVLNL
Sbjct: 307 NGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNL 366
Query: 1087 VLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDE 1263
VLGVLSGEFSKEREKA+ARG FQK REKQQ+EEDL+GYLDWITQAE+++ ED D+
Sbjct: 367 VLGVLSGEFSKEREKAKARGDFQKQREKQQMEEDLRGYLDWITQAEELD--MEDPSADD 423
Score = 246 bits (628), Expect = 5e-63
Identities = 131/261 (50%), Positives = 154/261 (58%)
Frame = +1
Query: 1357 KRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFF 1536
+RL + N VKS YW SEH+GQ WL Q AN
Sbjct: 509 RRLRRANRVLRARCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVL 568
Query: 1537 VILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSAR 1716
+ LF++EMLLK+Y LG + Y +S FNRFDCFVV ILE LV M+PLG+SVLR R
Sbjct: 569 LCLFTVEMLLKLYGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVR 628
Query: 1717 LLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQ 1896
LLRIFKVT++W GMQ+FGGKFNF+
Sbjct: 629 LLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTH 688
Query: 1897 PKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNY 2076
K R+ FDTF QALLTVFQILTGEDWN VMY GI ++GG G++VCIY+I+LFICGNY
Sbjct: 689 TK-RSTFDTFPQALLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNY 747
Query: 2077 ILLNVFLAIAVDNLADADSLT 2139
ILLNVFLAIAVDNLA D+ T
Sbjct: 748 ILLNVFLAIAVDNLASGDAGT 768
Score = 172 bits (437), Expect = 6e-41
Identities = 161/664 (24%), Positives = 282/664 (42%), Gaps = 33/664 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+RK C +++ F LIL I + ++LA P A ++N +L +Y F +F
Sbjct: 858 NPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAHS--FRNHILGYFDYAFTSIF 915
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
T+E +LK+ G H ++ R+ +N+LD ++V + L+S + +I VK LR RV
Sbjct: 916 TVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSSAIS--VVKILRVLRV 973
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLR ++ L+ V+ + A+ + +I ++ + ++A IG++LF GK + TC D
Sbjct: 974 LRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFY-TCTDE 1032
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
A+ P C +GS F P ++ VR N+ + NFDN
Sbjct: 1033 -----AKHTPQEC----KGS-FLVYPDGDVSRPLVRERLWVNSDF--------NFDNVLS 1074
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIY---------FVTLVILGSFFVLNLVLG 1095
AM+ +F + EGW ++Y DA + IY F+ +I+ +FF++N+ +G
Sbjct: 1075 AMMALFTVSTFEGWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVG 1134
Query: 1096 VLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIE---PVNEDEQEDEP 1266
+ F RA+G ++ + +L+++ + +++ +A+ + P N +
Sbjct: 1135 FVIITF-------RAQG--EQEYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYR--- 1182
Query: 1267 VAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXX 1446
WA V S F +
Sbjct: 1183 ------------------------VWAT-------------------VNSAAFEYLMFLL 1199
Query: 1447 XXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDC 1626
+HY Q+ ++ + N+ F LF++EM+LK+ + Y T +N FD
Sbjct: 1200 ILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDA 1259
Query: 1627 FVVISSILEFVLVYFDLMKPLG----------VSVLRSARLLRIFKVTKYWTXXXXXXXX 1776
+V+ SI++ + + LG ++ R R++R+ K+
Sbjct: 1260 LIVVGSIVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWT 1319
Query: 1777 XXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQI 1956
GMQ+FG + Q NF TF QA+L +F+
Sbjct: 1320 FIKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRC 1379
Query: 1957 LTGEDWNTVMYHGI-------ESFGGVG---TLGVIVCI-YYIVLFICGNYILLNVFLAI 2103
TGE W +M + ES G G T G I Y+I F+ ++++N+F+A+
Sbjct: 1380 ATGEAWQEIMLASLPGNRCDPESDFGPGEEFTCGSNFAIAYFISFFMLCAFLIINLFVAV 1439
Query: 2104 AVDN 2115
+DN
Sbjct: 1440 IMDN 1443
Score = 110 bits (276), Expect = 3e-22
Identities = 78/301 (25%), Positives = 143/301 (46%), Gaps = 1/301 (0%)
Frame = +1
Query: 3202 QNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR-LQYRVWWFVTSRAFEYVIFLI 3378
+ +G+ + E L R C+ +K + RR NR L+ R V S A + + L+
Sbjct: 480 ETQGDEDEEEGALASCTR-CLNKIMKTRVCRRLRRANRVLRARCRRAVKSNACYWAVLLL 538
Query: 3379 IVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDL 3558
+ +NT+++A +H+ + N + +F E +LK+ L P Y+S +N FD
Sbjct: 539 VFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKLYGLGPSAYVSSFFNRFDC 598
Query: 3559 LVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQAL 3738
VV G ++ T ++ G + I+ R R++R+ K+ + L+ + + S +++
Sbjct: 599 FVVCGGILETTLVEV--GAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKSI 656
Query: 3739 PYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQD 3918
+ LL+ L I++++GMQ FG D T R + F +FP A+L +F+ TGE W
Sbjct: 657 ASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKR-STFDTFPQALLTVFQILTGEDWNV 715
Query: 3919 IMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMD 4098
+M + G L YFI F+ +++++N+F+A+ +D
Sbjct: 716 VMYD-------GIMAYGGPFFPGML---------VCIYFIILFICGNYILLNVFLAIAVD 759
Query: 4099 N 4101
N
Sbjct: 760 N 760
Score = 89.7 bits (221), Expect = 7e-16
Identities = 140/693 (20%), Positives = 250/693 (35%), Gaps = 63/693 (9%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIY---QP-YPAQDSDYKNTLLETIEYV 387
N +R C V+ + +L ++ N + +A QP + Q +Y N +L
Sbjct: 515 NRVLRARCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVL------ 568
Query: 388 FIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKM-SIQGFDVKA 564
+ +FT+E +LK+ +G PSAY+ + +N D +V G++ T L ++ ++Q +
Sbjct: 569 -LCLFTVEMLLKLYGLG----PSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISV 623
Query: 565 LRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLH 744
LR R+LR ++ SL ++ ++L +M IA L+L + L I L
Sbjct: 624 LRCVRLLRIFKVTRHWASLSNLVASLLNSM---KSIASLLLLLFLFIIIFSL-------- 672
Query: 745 STCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITN 924
G G F + + +
Sbjct: 673 ------------------LGMQLFGGKFNFDQTHTKRS---------------------T 693
Query: 925 FDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREW-----PWIYFVTLVILGSFFVLNLV 1089
FD F A+LTVFQ ++ E W VMY A G + IYF+ L I G++ +LN+
Sbjct: 694 FDTFPQALLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVF 753
Query: 1090 LGV-----LSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAED--------- 1227
L + SG+ ++K +K EK L ++ +G + + + E+
Sbjct: 754 LAIAVDNLASGDAGTAKDKGG-----EKSNEK-DLPQENEGLVPGVEKEEEEGARREGAD 807
Query: 1228 -IEPVNEDEQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXX 1404
E E+E+E+E + P + L + N
Sbjct: 808 MEEEEEEEEEEEEEEEEEGAGGVELLQEVVPKEKVVPIPEGSAFFCLSQTNPLRKGCHTL 867
Query: 1405 LVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLG 1584
+ + + +H + F +F++E+LLKM G
Sbjct: 868 IHHHVFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFG 927
Query: 1585 F----TTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWT 1752
++ S FN D VV S++ F + + V +LR R+LR +
Sbjct: 928 AFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSSAISV---VKILRVLRVLRPLRAINRAK 984
Query: 1753 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF-------NFNPQQPK--- 1902
G+Q+F GKF PQ+ K
Sbjct: 985 GLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYTCTDEAKHTPQECKGSF 1044
Query: 1903 --------------------PRANFDTFVQALLTVFQILTGEDWNTVMYHGIESF----G 2010
NFD + A++ +F + T E W ++Y I+++ G
Sbjct: 1045 LVYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDAYAEDHG 1104
Query: 2011 GVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+ V + +++IV I + ++N+F+ +
Sbjct: 1105 PIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVI 1137
Score = 88.6 bits (218), Expect = 2e-15
Identities = 78/287 (27%), Positives = 117/287 (40%), Gaps = 31/287 (10%)
Frame = +1
Query: 2293 AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN 2472
A ++ + P+A LF L+ N R C +V F +L I + L P +
Sbjct: 61 AVASAQRSPRA--LFCLTLANPLRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPED 118
Query: 2473 --STRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSF 2646
+T N L +Y F +FTVE LK++ +GLV H ++ RN +NLLD ++V V L S
Sbjct: 119 DSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSV 178
Query: 2647 VL-----------RTDAMSXXXXXXXXXXXXXXXAINRAKG---LKHVVQCVIVAVKTIG 2784
+L T + G L V+ ++ A+ +
Sbjct: 179 LLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLL 238
Query: 2785 NIMLVTFMLQFMFAIIGVQLFKGTFF-LCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKR 2961
+I L+ + ++AIIG++LF G C L EAE ED P R
Sbjct: 239 HIALLVLFVIIIYAIIGLELFLGRMHKTCYFLGSDMEAE--------EDPSPCASSGSGR 290
Query: 2962 VWSNND--------------FNFDNVGDAMISLFVVSTFEGWPQLLY 3060
+ N NFDN AM+++F T EGW +LY
Sbjct: 291 ACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLY 337
Score = 82.4 bits (202), Expect = 1e-13
Identities = 78/310 (25%), Positives = 123/310 (39%), Gaps = 58/310 (18%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ F+ +I L I N V+L +P S L+ +F +F E VLKIVA
Sbjct: 92 KPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGL 151
Query: 3511 -LNPKNYISDRWNVFDLLVVVGSFIDI--------------TYGKLNPGGTNLISINFFR 3645
L+P YI + WN+ D ++VV + T GK PGG + R
Sbjct: 152 VLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGK--PGG---FDVKALR 206
Query: 3646 LFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF------- 3804
FRV+R ++L+S + +L + MK+ L ++ALL++ + IYA+IG++ F
Sbjct: 207 AFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKT 266
Query: 3805 ----------------------GKVALDDSTSIHRN--------NNFHSFPAAILVLFRS 3894
G+ + T NF +F A+L +F+
Sbjct: 267 CYFLGSDMEAEEDPSPCASSGSGRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQC 326
Query: 3895 ATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVIN 4074
T E W D++ D G + YF+S + SF V+N
Sbjct: 327 VTMEGWTDVLYWMQD---------------------AMGYELPWVYFVSLVIFGSFFVLN 365
Query: 4075 LFVAVIMDNF 4104
L + V+ F
Sbjct: 366 LVLGVLSGEF 375
Score = 44.7 bits (104), Expect = 0.027
Identities = 23/64 (35%), Positives = 37/64 (56%)
Frame = +1
Query: 1912 NFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNV 2091
NFD F A+LTVFQ +T E W V+Y ++ G + +Y++ L I G++ +LN+
Sbjct: 312 NFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMG-----YELPWVYFVSLVIFGSFFVLNL 366
Query: 2092 FLAI 2103
L +
Sbjct: 367 VLGV 370
>gi|4885103|ref|NP_005174.1| calcium channel, voltage-dependent, alpha
1F subunit; Cav1.4alpha1 [Homo sapiens]
gi|6165989|sp|O60840|CCAF_HUMAN Voltage-dependent L-type calcium
channel alpha-1F subunit (Voltage-gated calcium channel
alpha subunit Cav1.4)
gi|3183953|emb|CAA06916.1| L-type calcium channel alpha-1 subunit
[Homo sapiens]
gi|3297875|emb|CAA12175.1| L-type calcium channel alpha-1 subunit
[Homo sapiens]
Length = 1966
Score = 1005 bits (2598), Expect = 0.0
Identities = 503/819 (61%), Positives = 625/819 (75%), Gaps = 10/819 (1%)
Frame = +1
Query: 2278 MSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAED 2457
+ EV V PIP+ S+ F LS TN R C+ +++H FTN +L I++SS LAAED
Sbjct: 822 LQEVVPKEKVVPIPEGSAFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAED 881
Query: 2458 PLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSL 2637
P++A+S RN IL YFDY FTS+FTVEI LK+ VFG H+GSFCR+ FN+LD+LVV+VSL
Sbjct: 882 PIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSL 941
Query: 2638 TSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQF 2817
SF + + A+S AINRAKGLKHVVQCV VA++TIGNIM+VT +LQF
Sbjct: 942 ISFGIHSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQF 1001
Query: 2818 MFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNV 2997
MFA IGVQLFKG F+ C D +K T EC+G ++ Y DGD ++P+ ++R+W N+DFNFDNV
Sbjct: 1002 MFACIGVQLFKGKFYTCTDEAKHTPQECKGSFLVYPDGDVSRPLVRERLWVNSDFNFDNV 1061
Query: 2998 GDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXX 3177
AM++LF VSTFEGWP LLY AID+ ED GPI+N R +++
Sbjct: 1062 LSAMMALFTVSTFEGWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIF 1121
Query: 3178 XGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVTSRAF 3357
GFVI+TF+ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N QYRVW V S AF
Sbjct: 1122 VGFVIITFRAQGEQEYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWATVNSAAF 1181
Query: 3358 EYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISD 3537
EY++FL+I++NTV+LA +HY + F +D+ N++FTG+F E VLKI+A PK+Y +D
Sbjct: 1182 EYLMFLLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFTD 1241
Query: 3538 RWNVFDLLVVVGSFIDITYGKLNPGG--------TNLISINFFRLFRVMRLVKLLSRGEG 3693
WN FD L+VVGS +DI ++N GG ++ ISI FFRLFRVMRLVKLLS+GEG
Sbjct: 1242 AWNTFDALIVVGSIVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLLSKGEG 1301
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAA 3873
IRTLLWTF+KSFQALPYVALLI ++FFIYAVIGMQ FGKVAL D T I+RNNNF +FP A
Sbjct: 1302 IRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQA 1361
Query: 3874 ILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFML 4053
+L+LFR ATGEAWQ+IML+ RCDP SD G E CG+NFA YFISFFML
Sbjct: 1362 VLLLFRCATGEAWQEIMLASLPGN--RCDPESDF---GPGEEFTCGSNFAIAYFISFFML 1416
Query: 4054 CSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLR 4233
C+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+WSEYDP AKGRIKHLDVV LLR
Sbjct: 1417 CAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLR 1476
Query: 4234 KISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNIDEAN 4413
+I PPLGFGKLCPHR+ACKRLV+MNMPLNSDGTV FNATLFALVRT+LKI TEGN+++AN
Sbjct: 1477 RIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVTFNATLFALVRTSLKIKTEGNLEQAN 1536
Query: 4414 EQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEMEAKG 4593
++LR IK+IWKR + LLDEV+PP E++VTVGKFYATFLIQDYFR+F++RKE KG
Sbjct: 1537 QELRIVIKKIWKRMKQKLLDEVIPPP-DEEEVTVGKFYATFLIQDYFRKFRRRKE---KG 1592
Query: 4594 VL--PAQTPQAMALQAGLRTLHEIGPELKRAISGNLETD 4704
+L A + ALQAGLR+L ++GPE+++A++ + E +
Sbjct: 1593 LLGNDAAPSTSSALQAGLRSLQDLGPEMRQALTCDTEEE 1631
Score = 666 bits (1718), Expect = 0.0
Identities = 359/692 (51%), Positives = 431/692 (61%), Gaps = 53/692 (7%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+R+ CISIVEWKPF+ LIL I ANC+AL +Y P+P DS+ N LE +EYVF+V+F
Sbjct: 79 NPLRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIF 138
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQ------------ 546
T+E VLKIVA G + HPSAY+RN WN+LDFIIVV+GL S +L + +
Sbjct: 139 TVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPG 198
Query: 547 GFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLEL 726
GFDVKALRAFRVLRPLRLVSGVPSL +VLN+I++A++PLLHIALLVLFVI+IYAIIGLEL
Sbjct: 199 GFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLEL 258
Query: 727 FCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGP 906
F G++H TC + A++DP+PC + G A + EC WPGP
Sbjct: 259 FLGRMHKTCYFLGSDMEAEEDPSPCASSGSGRACTLNQT----------ECRGR--WPGP 306
Query: 907 NNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNL 1086
N GITNFDNF AMLTVFQCV++EGWTDV+YW+ DA+G E PW+YFV+LVI GSFFVLNL
Sbjct: 307 NGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNL 366
Query: 1087 VLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAE--DIEPVNEDEQED 1260
VLGVLSGEFSKEREKA+ARG FQK REKQQ+EEDL+GYLDWITQAE D+E + D+
Sbjct: 367 VLGVLSGEFSKEREKAKARGDFQKQREKQQMEEDLRGYLDWITQAEELDMEDPSADDNLG 426
Query: 1261 EPVAQTX---------XXXXXXXXXXXXXXXXXPSKWAARM------------------- 1356
+A+ P+ M
Sbjct: 427 PQLAELTNRRRGRLRWFSHSTRSTHSTSSHASLPASDTGSMTETQGDEDEEEGALASCTR 486
Query: 1357 -----------KRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWL 1503
+RL + N VKS YW SEH+GQ WL
Sbjct: 487 CLNKIMKTRVCRRLRRANRVLRARCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWL 546
Query: 1504 DHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMK 1683
Q AN + LF++EMLLK+Y LG + Y +S FNRFDCFVV ILE LV M+
Sbjct: 547 TQIQEYANKVLLCLFTVEMLLKLYGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQ 606
Query: 1684 PLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQV 1863
PLG+SVLR RLLRIFKVT++W GMQ+
Sbjct: 607 PLGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQL 666
Query: 1864 FGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCI 2043
FGGKFNF+ K R+ FDTF QALLTVFQILTGEDWN VMY GI ++GG G++VCI
Sbjct: 667 FGGKFNFDQTHTK-RSTFDTFPQALLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCI 725
Query: 2044 YYIVLFICGNYILLNVFLAIAVDNLADADSLT 2139
Y+I+LFICGNYILLNVFLAIAVDNLA D+ T
Sbjct: 726 YFIILFICGNYILLNVFLAIAVDNLASGDAGT 757
Score = 172 bits (437), Expect = 6e-41
Identities = 161/664 (24%), Positives = 282/664 (42%), Gaps = 33/664 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+RK C +++ F LIL I + ++LA P A ++N +L +Y F +F
Sbjct: 847 NPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAHS--FRNHILGYFDYAFTSIF 904
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
T+E +LK+ G H ++ R+ +N+LD ++V + L+S + +I VK LR RV
Sbjct: 905 TVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSSAIS--VVKILRVLRV 962
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLR ++ L+ V+ + A+ + +I ++ + ++A IG++LF GK + TC D
Sbjct: 963 LRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFY-TCTDE 1021
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
A+ P C +GS F P ++ VR N+ + NFDN
Sbjct: 1022 -----AKHTPQEC----KGS-FLVYPDGDVSRPLVRERLWVNSDF--------NFDNVLS 1063
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIY---------FVTLVILGSFFVLNLVLG 1095
AM+ +F + EGW ++Y DA + IY F+ +I+ +FF++N+ +G
Sbjct: 1064 AMMALFTVSTFEGWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVG 1123
Query: 1096 VLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIE---PVNEDEQEDEP 1266
+ F RA+G ++ + +L+++ + +++ +A+ + P N +
Sbjct: 1124 FVIITF-------RAQG--EQEYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYR--- 1171
Query: 1267 VAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXX 1446
WA V S F +
Sbjct: 1172 ------------------------VWAT-------------------VNSAAFEYLMFLL 1188
Query: 1447 XXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDC 1626
+HY Q+ ++ + N+ F LF++EM+LK+ + Y T +N FD
Sbjct: 1189 ILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDA 1248
Query: 1627 FVVISSILEFVLVYFDLMKPLG----------VSVLRSARLLRIFKVTKYWTXXXXXXXX 1776
+V+ SI++ + + LG ++ R R++R+ K+
Sbjct: 1249 LIVVGSIVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWT 1308
Query: 1777 XXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQI 1956
GMQ+FG + Q NF TF QA+L +F+
Sbjct: 1309 FIKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRC 1368
Query: 1957 LTGEDWNTVMYHGI-------ESFGGVG---TLGVIVCI-YYIVLFICGNYILLNVFLAI 2103
TGE W +M + ES G G T G I Y+I F+ ++++N+F+A+
Sbjct: 1369 ATGEAWQEIMLASLPGNRCDPESDFGPGEEFTCGSNFAIAYFISFFMLCAFLIINLFVAV 1428
Query: 2104 AVDN 2115
+DN
Sbjct: 1429 IMDN 1432
Score = 110 bits (276), Expect = 3e-22
Identities = 78/301 (25%), Positives = 143/301 (46%), Gaps = 1/301 (0%)
Frame = +1
Query: 3202 QNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR-LQYRVWWFVTSRAFEYVIFLI 3378
+ +G+ + E L R C+ +K + RR NR L+ R V S A + + L+
Sbjct: 469 ETQGDEDEEEGALASCTR-CLNKIMKTRVCRRLRRANRVLRARCRRAVKSNACYWAVLLL 527
Query: 3379 IVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDL 3558
+ +NT+++A +H+ + N + +F E +LK+ L P Y+S +N FD
Sbjct: 528 VFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKLYGLGPSAYVSSFFNRFDC 587
Query: 3559 LVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQAL 3738
VV G ++ T ++ G + I+ R R++R+ K+ + L+ + + S +++
Sbjct: 588 FVVCGGILETTLVEV--GAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKSI 645
Query: 3739 PYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQD 3918
+ LL+ L I++++GMQ FG D T R + F +FP A+L +F+ TGE W
Sbjct: 646 ASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKR-STFDTFPQALLTVFQILTGEDWNV 704
Query: 3919 IMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMD 4098
+M + G L YFI F+ +++++N+F+A+ +D
Sbjct: 705 VMYD-------GIMAYGGPFFPGML---------VCIYFIILFICGNYILLNVFLAIAVD 748
Query: 4099 N 4101
N
Sbjct: 749 N 749
Score = 89.7 bits (221), Expect = 7e-16
Identities = 140/693 (20%), Positives = 250/693 (35%), Gaps = 63/693 (9%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIY---QP-YPAQDSDYKNTLLETIEYV 387
N +R C V+ + +L ++ N + +A QP + Q +Y N +L
Sbjct: 504 NRVLRARCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVL------ 557
Query: 388 FIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKM-SIQGFDVKA 564
+ +FT+E +LK+ +G PSAY+ + +N D +V G++ T L ++ ++Q +
Sbjct: 558 -LCLFTVEMLLKLYGLG----PSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISV 612
Query: 565 LRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLH 744
LR R+LR ++ SL ++ ++L +M IA L+L + L I L
Sbjct: 613 LRCVRLLRIFKVTRHWASLSNLVASLLNSM---KSIASLLLLLFLFIIIFSL-------- 661
Query: 745 STCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITN 924
G G F + + +
Sbjct: 662 ------------------LGMQLFGGKFNFDQTHTKRS---------------------T 682
Query: 925 FDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREW-----PWIYFVTLVILGSFFVLNLV 1089
FD F A+LTVFQ ++ E W VMY A G + IYF+ L I G++ +LN+
Sbjct: 683 FDTFPQALLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVF 742
Query: 1090 LGV-----LSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAED--------- 1227
L + SG+ ++K +K EK L ++ +G + + + E+
Sbjct: 743 LAIAVDNLASGDAGTAKDKGG-----EKSNEK-DLPQENEGLVPGVEKEEEEGARREGAD 796
Query: 1228 -IEPVNEDEQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXX 1404
E E+E+E+E + P + L + N
Sbjct: 797 MEEEEEEEEEEEEEEEEEGAGGVELLQEVVPKEKVVPIPEGSAFFCLSQTNPLRKGCHTL 856
Query: 1405 LVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLG 1584
+ + + +H + F +F++E+LLKM G
Sbjct: 857 IHHHVFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFG 916
Query: 1585 F----TTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWT 1752
++ S FN D VV S++ F + + V +LR R+LR +
Sbjct: 917 AFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSSAISV---VKILRVLRVLRPLRAINRAK 973
Query: 1753 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF-------NFNPQQPK--- 1902
G+Q+F GKF PQ+ K
Sbjct: 974 GLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYTCTDEAKHTPQECKGSF 1033
Query: 1903 --------------------PRANFDTFVQALLTVFQILTGEDWNTVMYHGIESF----G 2010
NFD + A++ +F + T E W ++Y I+++ G
Sbjct: 1034 LVYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDAYAEDHG 1093
Query: 2011 GVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+ V + +++IV I + ++N+F+ +
Sbjct: 1094 PIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVI 1126
Score = 88.6 bits (218), Expect = 2e-15
Identities = 78/287 (27%), Positives = 117/287 (40%), Gaps = 31/287 (10%)
Frame = +1
Query: 2293 AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN 2472
A ++ + P+A LF L+ N R C +V F +L I + L P +
Sbjct: 61 AVASAQRSPRA--LFCLTLANPLRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPED 118
Query: 2473 --STRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSF 2646
+T N L +Y F +FTVE LK++ +GLV H ++ RN +NLLD ++V V L S
Sbjct: 119 DSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSV 178
Query: 2647 VL-----------RTDAMSXXXXXXXXXXXXXXXAINRAKG---LKHVVQCVIVAVKTIG 2784
+L T + G L V+ ++ A+ +
Sbjct: 179 LLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLL 238
Query: 2785 NIMLVTFMLQFMFAIIGVQLFKGTFF-LCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKR 2961
+I L+ + ++AIIG++LF G C L EAE ED P R
Sbjct: 239 HIALLVLFVIIIYAIIGLELFLGRMHKTCYFLGSDMEAE--------EDPSPCASSGSGR 290
Query: 2962 VWSNND--------------FNFDNVGDAMISLFVVSTFEGWPQLLY 3060
+ N NFDN AM+++F T EGW +LY
Sbjct: 291 ACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLY 337
Score = 82.4 bits (202), Expect = 1e-13
Identities = 78/310 (25%), Positives = 123/310 (39%), Gaps = 58/310 (18%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ F+ +I L I N V+L +P S L+ +F +F E VLKIVA
Sbjct: 92 KPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGL 151
Query: 3511 -LNPKNYISDRWNVFDLLVVVGSFIDI--------------TYGKLNPGGTNLISINFFR 3645
L+P YI + WN+ D ++VV + T GK PGG + R
Sbjct: 152 VLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGK--PGG---FDVKALR 206
Query: 3646 LFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF------- 3804
FRV+R ++L+S + +L + MK+ L ++ALL++ + IYA+IG++ F
Sbjct: 207 AFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKT 266
Query: 3805 ----------------------GKVALDDSTSIHRN--------NNFHSFPAAILVLFRS 3894
G+ + T NF +F A+L +F+
Sbjct: 267 CYFLGSDMEAEEDPSPCASSGSGRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQC 326
Query: 3895 ATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVIN 4074
T E W D++ D G + YF+S + SF V+N
Sbjct: 327 VTMEGWTDVLYWMQD---------------------AMGYELPWVYFVSLVIFGSFFVLN 365
Query: 4075 LFVAVIMDNF 4104
L + V+ F
Sbjct: 366 LVLGVLSGEF 375
>gi|9624973|ref|NP_062528.1| calcium channel, voltage-dependent, alpha
1F subunit; L-type dihydropyridine-sensitive calcium
channel alpha-1f subunit [Mus musculus]
gi|38372255|sp|Q9JIS7|CCAF_MOUSE Voltage-dependent L-type calcium
channel alpha-1F subunit (Voltage-gated calcium channel
alpha subunit Cav1.4)
gi|9294961|gb|AAF86764.1| L-type dihydropyridine-sensitive calcium
channel alpha-1f subunit [Mus musculus]
Length = 1985
Score = 1003 bits (2594), Expect = 0.0
Identities = 507/838 (60%), Positives = 630/838 (74%), Gaps = 10/838 (1%)
Frame = +1
Query: 2278 MSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAED 2457
+ EV V PIP+ S+ F LS TN R C+ +++H FT+ +L I++SS LAAED
Sbjct: 838 LQEVVPKEKVVPIPEGSAFFCLSQTNPLRKACHTLIHHHIFTSLILVFIILSSVSLAAED 897
Query: 2458 PLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSL 2637
P++A+S RN IL YFDY FTS+FTVEI LK+ VFG H+GSFCR+ FNLLD+LVV+VSL
Sbjct: 898 PIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNLLDLLVVSVSL 957
Query: 2638 TSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQF 2817
SF + + A+S AINRAKGLKHVVQCV VA++TIGNIM+VT +LQF
Sbjct: 958 ISFGIHSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQF 1017
Query: 2818 MFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNV 2997
MFA IGVQLFKG F+ C D +K T E +G ++ Y DGD ++P+ ++R+W N+DFNFDNV
Sbjct: 1018 MFACIGVQLFKGKFYSCTDEAKHTLKESKGSFLIYPDGDVSRPLVRERLWVNSDFNFDNV 1077
Query: 2998 GDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXX 3177
AM++LF VSTFEGWP LLY AID+N ED+GPI+N +++
Sbjct: 1078 LSAMMALFTVSTFEGWPALLYKAIDANAEDEGPIYNYHVEISVFFIVYIIIIAFFMMNIF 1137
Query: 3178 XGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVTSRAF 3357
GFVI+TF+ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N QYRVW V SRAF
Sbjct: 1138 VGFVIITFRAQGEQEYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWATVNSRAF 1197
Query: 3358 EYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISD 3537
EY++FL+I++NTV+LA +HY + F +D+ N++FTG+F E VLKI+A PK+Y +D
Sbjct: 1198 EYLMFLLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFAD 1257
Query: 3538 RWNVFDLLVVVGSFIDITYGKLNPGG--------TNLISINFFRLFRVMRLVKLLSRGEG 3693
WN FD L+VVGS +DI ++N GG T+ ISI FFRLFRVMRLVKLLS+GEG
Sbjct: 1258 AWNTFDALIVVGSVVDIAVTEVNNGGHLGESSEDTSRISITFFRLFRVMRLVKLLSKGEG 1317
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAA 3873
IRTLLWTF+KSFQALPYVALLI ++FFIYAVIGMQ FG VAL D T I+RNNNF +FP A
Sbjct: 1318 IRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMFGLVALQDGTQINRNNNFQTFPQA 1377
Query: 3874 ILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFML 4053
+L+LFR ATGEAWQ+IML+ RCDP SD G E CG++FA YFISFFML
Sbjct: 1378 VLLLFRCATGEAWQEIMLASLPGN--RCDPESDF---GPGEEFTCGSSFAIVYFISFFML 1432
Query: 4054 CSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLR 4233
C+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+WSEYDP AKGRIKHLDVV LLR
Sbjct: 1433 CAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLR 1492
Query: 4234 KISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNIDEAN 4413
+I PPLGFGKLCPHR+ACKRLV+MN+PLNSDGTV FNATLFALVRT+LKI TEGN+D+AN
Sbjct: 1493 RIQPPLGFGKLCPHRVACKRLVAMNVPLNSDGTVTFNATLFALVRTSLKIKTEGNLDQAN 1552
Query: 4414 EQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEMEAKG 4593
++LR IK+IWKR + LLDEV+PP E++VTVGKFYATFLIQDYFR+F++RKE KG
Sbjct: 1553 QELRMVIKKIWKRIKQKLLDEVIPPP-DEEEVTVGKFYATFLIQDYFRKFRRRKE---KG 1608
Query: 4594 VL--PAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDEPEPQHRRPHSLFNN 4761
+L A T + ALQAGLR+L ++GPE+++A++ E + +E Q NN
Sbjct: 1609 LLGREAPTSTSSALQAGLRSLQDLGPEIRQALTYVTEEEEEEEEAVGQEAEEEEAENN 1666
Score = 447 bits (1151), Expect = e-123
Identities = 222/349 (63%), Positives = 270/349 (76%), Gaps = 12/349 (3%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR+ CISIVEWKPF+ LIL I ANC+AL +Y P+P DS+ N LE +EYVF+V+F
Sbjct: 79 NPIRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIF 138
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQ------------ 546
T+E VLKIVA G + HPSAY+RN WN+LDFIIVV+GL S +L + +
Sbjct: 139 TVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPG 198
Query: 547 GFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLEL 726
GFDVKALRAFRVLRPLRLVSGVPSL +V+N+I++A++PLLHIALLVLFVI+IYAIIGLEL
Sbjct: 199 GFDVKALRAFRVLRPLRLVSGVPSLHIVVNSIMKALVPLLHIALLVLFVIIIYAIIGLEL 258
Query: 727 FCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGP 906
F G++H TC + A++DP+PC + GS C + + EC WPGP
Sbjct: 259 FLGRMHKTCYFLGSDMEAEEDPSPCASS--GSGRSCTLNHT--------ECRGR--WPGP 306
Query: 907 NNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNL 1086
N GITNFDNF AMLTVFQC+++EGWTDV+YW+ DA+G E PW+YFV+LVI GSFFVLNL
Sbjct: 307 NGGITNFDNFFFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNL 366
Query: 1087 VLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIE 1233
VLGVLSGEFSKEREKA+ARG FQK REKQQ+EEDL+GYLDWITQAE+++
Sbjct: 367 VLGVLSGEFSKEREKAKARGDFQKLREKQQMEEDLRGYLDWITQAEELD 415
Score = 241 bits (615), Expect = 1e-61
Identities = 127/244 (52%), Positives = 148/244 (60%)
Frame = +1
Query: 1408 VKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGF 1587
VKS YW SEH+GQ WL Q AN + LF++EMLLK+Y LG
Sbjct: 526 VKSNACYWAVLLLVFLNTLTIASEHHGQPLWLTQTQEYANKVLLCLFTVEMLLKLYGLGP 585
Query: 1588 TTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXX 1767
+ Y S FNRFDCFVV ILE LV M+PLG+SVLR RLLRIFKVT++W
Sbjct: 586 SVYVASFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASLSNL 645
Query: 1768 XXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTV 1947
GMQ+FGGKFNF+ K R+ FDTF QALLTV
Sbjct: 646 VASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTK-RSTFDTFPQALLTV 704
Query: 1948 FQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADA 2127
FQILTGEDWN VMY GI ++GG G++VC+Y+I+LFICGNYILLNVFLAIAVDNLA
Sbjct: 705 FQILTGEDWNVVMYDGIMAYGGPFFPGMLVCVYFIILFICGNYILLNVFLAIAVDNLASG 764
Query: 2128 DSLT 2139
D+ T
Sbjct: 765 DAGT 768
Score = 171 bits (433), Expect = 2e-40
Identities = 157/664 (23%), Positives = 282/664 (41%), Gaps = 33/664 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+RK C +++ F LIL I + ++LA P A ++N +L +Y F +F
Sbjct: 863 NPLRKACHTLIHHHIFTSLILVFIILSSVSLAAEDPIRAHS--FRNHILGYFDYAFTSIF 920
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
T+E +LK+ G H ++ R+ +N+LD ++V + L+S + +I VK LR RV
Sbjct: 921 TVEILLKMTVFGAFLHRGSFCRSWFNLLDLLVVSVSLISFGIHSSAIS--VVKILRVLRV 978
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLR ++ L+ V+ + A+ + +I ++ + ++A IG++LF GK +S C D
Sbjct: 979 LRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYS-CTDE 1037
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
A L +++GS F P ++ VR N+ + NFDN
Sbjct: 1038 AKHTL---------KESKGS-FLIYPDGDVSRPLVRERLWVNSDF--------NFDNVLS 1079
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIY---------FVTLVILGSFFVLNLVLG 1095
AM+ +F + EGW ++Y DA + IY F+ +I+ +FF++N+ +G
Sbjct: 1080 AMMALFTVSTFEGWPALLYKAIDANAEDEGPIYNYHVEISVFFIVYIIIIAFFMMNIFVG 1139
Query: 1096 VLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIE---PVNEDEQEDEP 1266
+ F RA+G ++ + +L+++ + +++ +A+ + P N +
Sbjct: 1140 FVIITF-------RAQG--EQEYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYR--- 1187
Query: 1267 VAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXX 1446
WA V S+ F +
Sbjct: 1188 ------------------------VWAT-------------------VNSRAFEYLMFLL 1204
Query: 1447 XXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDC 1626
+HY Q+ ++ + N+ F LF++EM+LK+ + Y +N FD
Sbjct: 1205 ILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFADAWNTFDA 1264
Query: 1627 FVVISSILEFVLVYFDLMKPLG----------VSVLRSARLLRIFKVTKYWTXXXXXXXX 1776
+V+ S+++ + + LG ++ R R++R+ K+
Sbjct: 1265 LIVVGSVVDIAVTEVNNGGHLGESSEDTSRISITFFRLFRVMRLVKLLSKGEGIRTLLWT 1324
Query: 1777 XXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQI 1956
GMQ+FG + Q NF TF QA+L +F+
Sbjct: 1325 FIKSFQALPYVALLIAMIFFIYAVIGMQMFGLVALQDGTQINRNNNFQTFPQAVLLLFRC 1384
Query: 1957 LTGEDWNTVMYHGI-------ESFGGVG---TLG-VIVCIYYIVLFICGNYILLNVFLAI 2103
TGE W +M + ES G G T G +Y+I F+ ++++N+F+A+
Sbjct: 1385 ATGEAWQEIMLASLPGNRCDPESDFGPGEEFTCGSSFAIVYFISFFMLCAFLIINLFVAV 1444
Query: 2104 AVDN 2115
+DN
Sbjct: 1445 IMDN 1448
Score = 107 bits (268), Expect = 3e-21
Identities = 72/283 (25%), Positives = 136/283 (47%), Gaps = 1/283 (0%)
Frame = +1
Query: 3256 KCIEFALKAKPHRRYIPRNR-LQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRG 3432
+C+ +K + R + NR L+ R V S A + + L++ +NT+++A +H+
Sbjct: 497 RCLNKIMKTRICRHFRRANRGLRARCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPLW 556
Query: 3433 FEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPG 3612
+ N + +F E +LK+ L P Y++ +N FD VV G ++ T ++ G
Sbjct: 557 LTQTQEYANKVLLCLFTVEMLLKLYGLGPSVYVASFFNRFDCFVVCGGILETTLVEV--G 614
Query: 3613 GTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIG 3792
+ I+ R R++R+ K+ + L+ + + S +++ + LL+ L I++++G
Sbjct: 615 AMQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLG 674
Query: 3793 MQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSD 3972
MQ FG D T R + F +FP A+L +F+ TGE W +M
Sbjct: 675 MQLFGGKFNFDQTHTKR-STFDTFPQALLTVFQILTGEDWNVVMYD-------GIMAYGG 726
Query: 3973 DYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDN 4101
+ G L YFI F+ +++++N+F+A+ +DN
Sbjct: 727 PFFPGML---------VCVYFIILFICGNYILLNVFLAIAVDN 760
Score = 90.9 bits (224), Expect = 3e-16
Identities = 83/300 (27%), Positives = 123/300 (40%), Gaps = 36/300 (12%)
Frame = +1
Query: 2269 PRRMSE-----VPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVS 2433
PRR ++ A ++ + P+A LF L+ TN R C +V F +L I +
Sbjct: 48 PRRRTQHNKHKTVAVASAQRSPRA--LFCLTLTNPIRRSCISIVEWKPFDILILLTIFAN 105
Query: 2434 SAMLAAEDPLQAN--STRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNL 2607
L P + +T N L +Y F +FTVE LK++ +GLV H ++ RN +NL
Sbjct: 106 CVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNL 165
Query: 2608 LDILVVAVSLTSFVL-----------RTDAMSXXXXXXXXXXXXXXXAINRAKG---LKH 2745
LD ++V V L S +L T + G L
Sbjct: 166 LDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHI 225
Query: 2746 VVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFF-LCNDLSKMTEAECRGEYIHY 2922
VV ++ A+ + +I L+ + ++AIIG++LF G C L EAE
Sbjct: 226 VVNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLGSDMEAE-------- 277
Query: 2923 EDGDPTKPVSKKRVWSNND--------------FNFDNVGDAMISLFVVSTFEGWPQLLY 3060
ED P R + N NFDN AM+++F T EGW +LY
Sbjct: 278 EDPSPCASSGSGRSCTLNHTECRGRWPGPNGGITNFDNFFFAMLTVFQCITMEGWTDVLY 337
Score = 85.5 bits (210), Expect = 1e-14
Identities = 137/692 (19%), Positives = 243/692 (34%), Gaps = 62/692 (8%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIY---QP-YPAQDSDYKNTLLETIEYV 387
N +R C V+ + +L ++ N + +A QP + Q +Y N +L
Sbjct: 515 NRGLRARCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPLWLTQTQEYANKVL------ 568
Query: 388 FIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKM-SIQGFDVKA 564
+ +FT+E +LK+ +G PS Y+ + +N D +V G++ T L ++ ++Q +
Sbjct: 569 -LCLFTVEMLLKLYGLG----PSVYVASFFNRFDCFVVCGGILETTLVEVGAMQPLGISV 623
Query: 565 LRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLH 744
LR R+LR ++ SL ++ ++L +M IA L+L + L I L
Sbjct: 624 LRCVRLLRIFKVTRHWASLSNLVASLLNSM---KSIASLLLLLFLFIIIFSL-------- 672
Query: 745 STCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITN 924
G G F + + +
Sbjct: 673 ------------------LGMQLFGGKFNFDQTHTKRS---------------------T 693
Query: 925 FDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREW-----PWIYFVTLVILGSFFVLNLV 1089
FD F A+LTVFQ ++ E W VMY A G + +YF+ L I G++ +LN+
Sbjct: 694 FDTFPQALLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCVYFIILFICGNYILLNVF 753
Query: 1090 LGV-----LSGEFSKEREKARARGLFQKFREKQQL------EEDLKGYLDWIT---QAED 1227
L + SG+ ++K R + ++ ++ ED KG E+
Sbjct: 754 LAIAVDNLASGDAGTAKDKGREKSSEGNPPKENKVLVPGGENEDAKGARSEGAAPGMEEE 813
Query: 1228 IEPVNEDEQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXL 1407
E E+E+E+E + P + L + N +
Sbjct: 814 EEEEEEEEEEEEEEEENGAGHVELLQEVVPKEKVVPIPEGSAFFCLSQTNPLRKACHTLI 873
Query: 1408 VKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGF 1587
+ + +H + F +F++E+LLKM G
Sbjct: 874 HHHIFTSLILVFIILSSVSLAAEDPIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGA 933
Query: 1588 ----TTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTX 1755
++ S FN D VV S++ F + + V +LR R+LR +
Sbjct: 934 FLHRGSFCRSWFNLLDLLVVSVSLISFGIHSSAISV---VKILRVLRVLRPLRAINRAKG 990
Query: 1756 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRA-------- 1911
G+Q+F GKF + K
Sbjct: 991 LKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYSCTDEAKHTLKESKGSFL 1050
Query: 1912 ----------------------NFDTFVQALLTVFQILTGEDWNTVMYHGI----ESFGG 2013
NFD + A++ +F + T E W ++Y I E G
Sbjct: 1051 IYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDANAEDEGP 1110
Query: 2014 VGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+ V + +++IV I + ++N+F+ +
Sbjct: 1111 IYNYHVEISVFFIVYIIIIAFFMMNIFVGFVI 1142
Score = 79.7 bits (195), Expect = 7e-13
Identities = 78/310 (25%), Positives = 127/310 (40%), Gaps = 58/310 (18%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ F+ +I L I N V+L +P S L+ +F +F E VLKIVA
Sbjct: 92 KPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGL 151
Query: 3511 -LNPKNYISDRWNVFDLLVVVGSFIDI--------------TYGKLNPGGTNLISINFFR 3645
L+P YI + WN+ D ++VV + T GK PGG + R
Sbjct: 152 VLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGK--PGG---FDVKALR 206
Query: 3646 LFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV--- 3813
FRV+R ++L+S + ++ + MK+ L ++ALL++ + IYA+IG++ F G++
Sbjct: 207 AFRVLRPLRLVSGVPSLHIVVNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKT 266
Query: 3814 ---------ALDDSTSIHRN------------------------NNFHSFPAAILVLFRS 3894
A +D + + NF +F A+L +F+
Sbjct: 267 CYFLGSDMEAEEDPSPCASSGSGRSCTLNHTECRGRWPGPNGGITNFDNFFFAMLTVFQC 326
Query: 3895 ATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVIN 4074
T E W D++ D G + YF+S + SF V+N
Sbjct: 327 ITMEGWTDVLYWMQD---------------------AMGYELPWVYFVSLVIFGSFFVLN 365
Query: 4075 LFVAVIMDNF 4104
L + V+ F
Sbjct: 366 LVLGVLSGEF 375
Score = 45.1 bits (105), Expect = 0.020
Identities = 23/64 (35%), Positives = 37/64 (56%)
Frame = +1
Query: 1912 NFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNV 2091
NFD F A+LTVFQ +T E W V+Y ++ G + +Y++ L I G++ +LN+
Sbjct: 312 NFDNFFFAMLTVFQCITMEGWTDVLYWMQDAMG-----YELPWVYFVSLVIFGSFFVLNL 366
Query: 2092 FLAI 2103
L +
Sbjct: 367 VLGV 370
>gi|164761|gb|AAA31159.1| dihydropyridine calcium channel receptor
protein
Length = 1873
Score = 1003 bits (2593), Expect = 0.0
Identities = 511/836 (61%), Positives = 617/836 (73%), Gaps = 21/836 (2%)
Frame = +1
Query: 2260 SARPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSA 2439
S RPR ++E+ PIP+ASS FI S TN RV C+ +VN ++FTN +L IL+SSA
Sbjct: 755 SPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKVRVLCHRIVNATWFTNFILLFILLSSA 814
Query: 2440 MLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDIL 2619
LAAEDP++A S RN IL YFD FTSVFTVEI LK+ +G HKGSFCRN FN+LD+L
Sbjct: 815 ALAAEDPIRAESVRNQILGYFDIAFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNILDLL 874
Query: 2620 VVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLV 2799
VVAVSL S L + +S AINRAKGLKHVVQCV VA++TIGNI+LV
Sbjct: 875 VVAVSLISMGLESSTISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVLV 934
Query: 2800 TFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNND 2979
T +LQFMFA IGVQLFKG FF CNDLSKMTE ECRG Y Y+DGDPT+ + R W +ND
Sbjct: 935 TTLLQFMFACIGVQLFKGKFFSCNDLSKMTEEECRGYYYVYKDGDPTQMELRPRQWIHND 994
Query: 2980 FNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXX 3159
F+FDNV AM+SLF VSTFEGWPQLLY AIDSNEED GP++N+R +A+
Sbjct: 995 FHFDNVLSAMMSLFTVSTFEGWPQLLYRAIDSNEEDMGPVYNNRVEMAIFFIIYIILIAF 1054
Query: 3160 XXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWF 3339
GFVIVTFQ +GE EY+NCELDKNQR+C+++ALKA+P R YIP+N QY+VW+
Sbjct: 1055 FMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQVWYV 1114
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
VTS FEY++F +I++NT+ L +HY S D+ N+ FT +F E +LK++A
Sbjct: 1115 VTSSYFEYLMFALIMLNTICLGMQHYHQSEEMNHISDILNVAFTIIFTLEMILKLLAFKA 1174
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITY--------------------GKLNPGGTNLISINF 3639
+ Y D WNVFD L+V+GS ID+ G ++P + IS F
Sbjct: 1175 RGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARISSAF 1234
Query: 3640 FRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVAL 3819
FRLFRVMRL+KLLSR EG+RTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL
Sbjct: 1235 FRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIAL 1294
Query: 3820 DDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNE 3999
D T I+RNNNF +FP A+L+LFR ATGEAWQ+I+L+CS + CDP SD Y G E
Sbjct: 1295 VDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGK--LCDPESD-YAPG--EE 1349
Query: 4000 SRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEY 4179
CG NFAY YFISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF +W+EY
Sbjct: 1350 YTCGTNFAYYYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAEY 1409
Query: 4180 DPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFA 4359
DP+AKGRIKHLDVVTLLR+I PPLGFGK CPHR+ACKRLV MNMPLNSDGTV FNATLFA
Sbjct: 1410 DPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFA 1469
Query: 4360 LVRTNLKIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFL 4539
LVRT LKI TEGN ++ANE+LR+ IK+IWKRT LLD+V+PP G +D+VTVGKFYATFL
Sbjct: 1470 LVRTALKIKTEGNFEQANEELRAIIKKIWKRTSMKLLDQVIPPIG-DDEVTVGKFYATFL 1528
Query: 4540 IQDYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTL-HEIGPELKRAISGNLETD 4704
IQ++FR+F KR+E E G P + + +QAGLRT+ E PE++R ISG+L +
Sbjct: 1529 IQEHFRKFMKRQE-EYYGYRPKK--DTVQIQAGLRTIEEEAAPEIRRTISGDLTAE 1581
Score = 674 bits (1739), Expect = 0.0
Identities = 357/687 (51%), Positives = 448/687 (64%), Gaps = 17/687 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
KK+P +KPL + V+ NP+RK CISIVEWKPFE +IL I ANC+AL
Sbjct: 13 KKQP--KKPLPE--VLPRPPRALFCLTLQNPLRKACISIVEWKPFETIILLTIFANCVAL 68
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A+Y P P D++ N LE +EY F+ VF+IE +KI+A GF+FH AYLR+ WN+LDFI
Sbjct: 69 AVYLPMPEDDNNSLNLGLEKLEYFFLTVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFI 128
Query: 496 IVVIGLVSTILSKMSI------------QGFDVKALRAFRVLRPLRLVSGVPSLQVVLNA 639
IV +G+ + IL ++++ G DVKALRAFRVLRPLRLVSGVPSLQVVLN+
Sbjct: 129 IVFLGVFTAILEQVNVIQSNTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNS 188
Query: 640 ILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLA---QKDPTPCGTD 810
I +AM+PL HIALLVLF+++IYAIIGLELF GK+H TC T +A + P+PC
Sbjct: 189 IFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYYIGTDIVATVENEKPSPCART 248
Query: 811 TEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTD 990
GS C + S EC WPGPN+GIT+FDNFG +MLTV+QC+++EGWTD
Sbjct: 249 --GSGRPCTINGS--------ECRGG--WPGPNHGITHFDNFGFSMLTVYQCITMEGWTD 296
Query: 991 VMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREK 1170
V+YWVNDA+G EWPWIYFVTL++LGSFF+LNLVLGVLSGEF+KEREKA++RG FQK REK
Sbjct: 297 VLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREK 356
Query: 1171 QQLEEDLKGYLDWITQAE--DIEPVNEDEQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKW 1344
QQLEEDL+GY+ WITQ E D+E + E + E +K
Sbjct: 357 QQLEEDLRGYMSWITQGEVMDVEDLREGKLSLEEGGSDTESLYEIEGL---------NKI 407
Query: 1345 AARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMA 1524
++ + N LVKS+ FYW SEH+ Q WL H Q +A
Sbjct: 408 IQFIRHWRQWNRVFRWKCHDLVKSRVFYWLVILIVALNTLSIASEHHNQPLWLTHLQDIA 467
Query: 1525 NLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVL 1704
N + LF++EMLLKMY LG Y S FNRFDCFVV S ILE +LV M PLG+SVL
Sbjct: 468 NRVLLSLFTIEMLLKMYGLGLRQYFMSIFNRFDCFVVCSGILELLLVESGAMTPLGISVL 527
Query: 1705 RSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNF 1884
R RLLR+FK+TKYWT GMQ+FGG+++F
Sbjct: 528 RCIRLLRLFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIIIFALLGMQLFGGRYDF 587
Query: 1885 NPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFI 2064
+ + R+NFD F QAL++VFQ+LTGEDWN+VMY+GI ++GG GV+VCIY+I+LF+
Sbjct: 588 EDTEVR-RSNFDNFPQALISVFQVLTGEDWNSVMYNGIMAYGGPSYPGVLVCIYFIILFV 646
Query: 2065 CGNYILLNVFLAIAVDNLADADSLTNA 2145
CGNYILLNVFLAIAVDNLA+A+SLT+A
Sbjct: 647 CGNYILLNVFLAIAVDNLAEAESLTSA 673
Score = 171 bits (432), Expect = 2e-40
Identities = 154/671 (22%), Positives = 283/671 (41%), Gaps = 73/671 (10%)
Frame = +1
Query: 2308 KPIPKA-----SSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQA- 2469
KP+P+ +LF L+ N R C +V F +L I + LA P+
Sbjct: 18 KPLPEVLPRPPRALFCLTLQNPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPED 77
Query: 2470 -NSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSF 2646
N++ N+ L +YFF +VF++E +K+I +G +FH+ ++ R+ +N+LD ++V + + +
Sbjct: 78 DNNSLNLGLEKLEYFFLTVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFIIVFLGVFTA 137
Query: 2647 VLR--------TDAMSXXXXXXXXXXXXXXXAINRAK------GLKHVVQCVIVAVKTIG 2784
+L T MS + + L+ V+ + A+ +
Sbjct: 138 ILEQVNVIQSNTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLF 197
Query: 2785 NIMLVTFMLQFMFAIIGVQLFKGT-----FFLCNDLSKMTEAECRGEYIHYEDGDP-TKP 2946
+I L+ + ++AIIG++LFKG +++ D+ E E G P T
Sbjct: 198 HIALLVLFMVIIYAIIGLELFKGKMHKTCYYIGTDIVATVENEKPSPCARTGSGRPCTIN 257
Query: 2947 VSKKRV-WSNNDF---NFDNVGDAMISLFVVSTFEG---------------WPQLLYVAI 3069
S+ R W + +FDN G +M++++ T EG WP + +V +
Sbjct: 258 GSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEWPWIYFVTL 317
Query: 3070 D-------------------SNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVI 3192
+ E +K + Q + +
Sbjct: 318 ILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLEEDLRGYMSWITQGEVMD 377
Query: 3193 VTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPR-NRL-QYRVWWFVTSRAFEYV 3366
V EG+ E D IE K R+ + NR+ +++ V SR F ++
Sbjct: 378 VEDLREGKLSLEEGGSDTESLYEIEGLNKIIQFIRHWRQWNRVFRWKCHDLVKSRVFYWL 437
Query: 3367 IFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWN 3546
+ LI+ +NT+S+A +H+ D+ N + +F E +LK+ L + Y +N
Sbjct: 438 VILIVALNTLSIASEHHNQPLWLTHLQDIANRVLLSLFTIEMLLKMYGLGLRQYFMSIFN 497
Query: 3547 VFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKS 3726
FD VV +++ + G + I+ R R++RL K+ + L+ + + S
Sbjct: 498 RFDCFVVCSGILELLL--VESGAMTPLGISVLRCIRLLRLFKITKYWTSLSNLVASLLNS 555
Query: 3727 FQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGE 3906
+++ + LL+ L I+A++GMQ FG + T + R+N F +FP A++ +F+ TGE
Sbjct: 556 IRSIASLLLLLFLFIIIFALLGMQLFGGRYDFEDTEVRRSN-FDNFPQALISVFQVLTGE 614
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP------YFISFFMLCSFLV 4068
W +M N +YP YFI F+ ++++
Sbjct: 615 DWNSVMY----------------------NGIMAYGGPSYPGVLVCIYFIILFVCGNYIL 652
Query: 4069 INLFVAVIMDN 4101
+N+F+A+ +DN
Sbjct: 653 LNVFLAIAVDN 663
Score = 120 bits (301), Expect = 4e-25
Identities = 99/343 (28%), Positives = 156/343 (44%), Gaps = 12/343 (3%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V N +R LC IV F IL I + AL
Sbjct: 757 RPRPLAELQLKEKAVPIPEASSFFIFSPTNKVRVLCHRIVNATWFTNFILLFILLSSAAL 816
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P A+ +N +L + F VFT+E VLK+ G H ++ RN +NILD +
Sbjct: 817 AAEDPIRAES--VRNQILGYFDIAFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNILDLL 874
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S L +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 875 VVAVSLISMGLESSTIS--VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIV 932
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLT 855
L+ + ++A IG++LF GK S C D L++ C G + + D T
Sbjct: 933 LVTTLLQFMFACIGVQLFKGKFFS-CND-----LSKMTEEEC----RGYYYVYKDGDP-T 981
Query: 856 NMGVRWECSSNTTWPGPNNGITN---FDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGRE 1026
M +R P I N FDN AM+++F + EGW ++Y D+ +
Sbjct: 982 QMELR-----------PRQWIHNDFHFDNVLSAMMSLFTVSTFEGWPQLLYRAIDSNEED 1030
Query: 1027 WPWIY---------FVTLVILGSFFVLNLVLGVLSGEFSKERE 1128
+Y F+ +IL +FF++N+ +G + F ++ E
Sbjct: 1031 MGPVYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGE 1073
Score = 87.4 bits (215), Expect = 4e-15
Identities = 77/336 (22%), Positives = 140/336 (40%), Gaps = 39/336 (11%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP + +V FE+L+ +I N I L + Q Y S+ N + + + F ++F
Sbjct: 1105 NPYQYQVWYVVTSSYFEYLMFALIMLNTICLGM-QHY--HQSEEMNHISDILNVAFTIIF 1161
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKM-----SIQGF----- 552
T+E +LK++A F Y + WN+ DF+IV+ ++ ILS++ S G
Sbjct: 1162 TLEMILKLLA----FKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGG 1217
Query: 553 -------DVKA------LRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFV 693
D A R FRV+R ++L+S ++ +L +++ L ++ALL++ +
Sbjct: 1218 GCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVML 1277
Query: 694 ILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRW 873
IYA+IG+++F G++A D T
Sbjct: 1278 FFIYAVIGMQMF-------------GKIALVDGTQI------------------------ 1300
Query: 874 ECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVN--------------- 1008
N NF F A+L +F+C + E W +++ +
Sbjct: 1301 ------------NRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGE 1348
Query: 1009 -DAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
G + + YF++ +L +F ++NL + V+ F
Sbjct: 1349 EYTCGTNFAYYYFISFYMLCAFLIINLFVAVIMDNF 1384
Score = 75.9 bits (185), Expect = 1e-11
Identities = 69/309 (22%), Positives = 127/309 (40%), Gaps = 57/309 (18%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDV----FNLIFTGVFAFEAVLKIVA-- 3510
+ FE +I L I N V+LA + P + L++ F VF+ EA +KI+A
Sbjct: 51 KPFETIILLTIFANCVALAV-YLPMPEDDNNSLNLGLEKLEYFFLTVFSIEAAMKIIAYG 109
Query: 3511 --LNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNL---------ISINFFRLFRV 3657
+ Y+ WNV D ++V ++N +N + + R FRV
Sbjct: 110 FLFHQDAYLRSGWNVLDFIIVFLGVFTAILEQVNVIQSNTAPMSSKGAGLDVKALRAFRV 169
Query: 3658 MRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GK-------V 3813
+R ++L+S ++ +L + K+ L ++ALL++ + IYA+IG++ F GK +
Sbjct: 170 LRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYYI 229
Query: 3814 ALDDSTSI--------------------------------HRNNNFHSFPAAILVLFRSA 3897
D ++ H +F +F ++L +++
Sbjct: 230 GTDIVATVENEKPSPCARTGSGRPCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCI 289
Query: 3898 TGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINL 4077
T E W D++ +D GN + + YF++ +L SF ++NL
Sbjct: 290 TMEGWTDVLYWVNDA---------------------IGNEWPWIYFVTLILLGSFFILNL 328
Query: 4078 FVAVIMDNF 4104
+ V+ F
Sbjct: 329 VLGVLSGEF 337
Score = 73.9 bits (180), Expect = 4e-11
Identities = 58/247 (23%), Positives = 98/247 (39%), Gaps = 34/247 (13%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HY QSE ++H + N+ F I+F++EM+LK+ + Y +N FD +VI SI++
Sbjct: 1138 QHYHQSEEMNHISDILNVAFTIIFTLEMILKLLAFKARGYFGDPWNVFDFLIVIGSIIDV 1197
Query: 1657 VLVYFDLM----------------------KPLGVSVLRSARLLRIFKVTKYWTXXXXXX 1770
+L D + + R R++R+ K+
Sbjct: 1198 ILSEIDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLL 1257
Query: 1771 XXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVF 1950
GMQ+FG + Q NF TF QA+L +F
Sbjct: 1258 WTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLF 1317
Query: 1951 QILTGEDWNTVMY----------HGIESFGGVGTLGVIVCIYYIVLF--ICGNYILLNVF 2094
+ TGE W ++ + G T G YY + F +C ++++N+F
Sbjct: 1318 RCATGEAWQEILLACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCA-FLIINLF 1376
Query: 2095 LAIAVDN 2115
+A+ +DN
Sbjct: 1377 VAVIMDN 1383
Score = 49.3 bits (116), Expect = 0.001
Identities = 44/156 (28%), Positives = 74/156 (47%), Gaps = 40/156 (25%)
Frame = +1
Query: 919 TNFDNFGLAMLTVFQCVSLEGWTDVMY-WVNDAVGREWP----WIYFVTLVILGSFFVLN 1083
+NFDNF A+++VFQ ++ E W VMY + G +P IYF+ L + G++ +LN
Sbjct: 595 SNFDNFPQALISVFQVLTGEDWNSVMYNGIMAYGGPSYPGVLVCIYFIILFVCGNYILLN 654
Query: 1084 LVLGV-----------LSGEFSKEREKAR---ARGLFQKFREK-----QQLEEDLKG--- 1197
+ L + S + +K E+ R +RGL K E+ ++LE+ KG
Sbjct: 655 VFLAIAVDNLAEAESLTSAQKAKAEERKRRKMSRGLPDKREEEKSVMAKKLEQKPKGEGI 714
Query: 1198 ----------YLDWITQAEDIEPVNE---DEQEDEP 1266
+ + + +D P + D++EDEP
Sbjct: 715 PTTAKLKVDEFESNVNEVKDPYPSADFPGDDEEDEP 750
Score = 42.7 bits (99), Expect = 0.10
Identities = 47/233 (20%), Positives = 89/233 (38%), Gaps = 38/233 (16%)
Frame = +1
Query: 1525 NLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLG 1692
++ F +F++E++LKM + G ++ + FN D VV S++ L +
Sbjct: 836 DIAFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNILDLLVVAVSLISMGLESSTISV--- 892
Query: 1693 VSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGG 1872
V +LR R+LR + G+Q+F G
Sbjct: 893 VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVLVTTLLQFMFACIGVQLFKG 952
Query: 1873 KF----------------------NFNPQQPKPRA--------NFDTFVQALLTVFQILT 1962
KF + +P Q + R +FD + A++++F + T
Sbjct: 953 KFFSCNDLSKMTEEECRGYYYVYKDGDPTQMELRPRQWIHNDFHFDNVLSAMMSLFTVST 1012
Query: 1963 GEDWNTVMYHGIES----FGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
E W ++Y I+S G V V + I++I+ I + ++N+F+ +
Sbjct: 1013 FEGWPQLLYRAIDSNEEDMGPVYNNRVEMAIFFIIYIILIAFFMMNIFVGFVI 1065
>gi|116408|sp|P07293|CCAS_RABIT Voltage-dependent L-type calcium
channel alpha-1S subunit (Voltage-gated calcium channel
alpha subunit Cav1.1) (Calcium channel, L type, alpha-1
polypeptide, isoform 3, skeletal muscle)
gi|90003|pir||A30063 dihydropyridine receptor - rabbit
gi|1548|emb|CAA29355.1| unnamed protein product [Oryctolagus
cuniculus]
gi|225676|prf||1310328A Ca channel blocker receptor
Length = 1873
Score = 1003 bits (2593), Expect = 0.0
Identities = 511/836 (61%), Positives = 617/836 (73%), Gaps = 21/836 (2%)
Frame = +1
Query: 2260 SARPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSA 2439
S RPR ++E+ PIP+ASS FI S TN RV C+ +VN ++FTN +L IL+SSA
Sbjct: 755 SPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKVRVLCHRIVNATWFTNFILLFILLSSA 814
Query: 2440 MLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDIL 2619
LAAEDP++A S RN IL YFD FTSVFTVEI LK+ +G HKGSFCRN FN+LD+L
Sbjct: 815 ALAAEDPIRAESVRNQILGYFDIAFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNILDLL 874
Query: 2620 VVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLV 2799
VVAVSL S L + +S AINRAKGLKHVVQCV VA++TIGNI+LV
Sbjct: 875 VVAVSLISMGLESSTISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVLV 934
Query: 2800 TFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNND 2979
T +LQFMFA IGVQLFKG FF CNDLSKMTE ECRG Y Y+DGDPT+ + R W +ND
Sbjct: 935 TTLLQFMFACIGVQLFKGKFFSCNDLSKMTEEECRGYYYVYKDGDPTQMELRPRQWIHND 994
Query: 2980 FNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXX 3159
F+FDNV AM+SLF VSTFEGWPQLLY AIDSNEED GP++N+R +A+
Sbjct: 995 FHFDNVLSAMMSLFTVSTFEGWPQLLYRAIDSNEEDMGPVYNNRVEMAIFFIIYIILIAF 1054
Query: 3160 XXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWF 3339
GFVIVTFQ +GE EY+NCELDKNQR+C+++ALKA+P R YIP+N QY+VW+
Sbjct: 1055 FMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQVWYV 1114
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
VTS FEY++F +I++NT+ L +HY S D+ N+ FT +F E +LK++A
Sbjct: 1115 VTSSYFEYLMFALIMLNTICLGMQHYHQSEEMNHISDILNVAFTIIFTLEMILKLLAFKA 1174
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITY--------------------GKLNPGGTNLISINF 3639
+ Y D WNVFD L+V+GS ID+ G ++P + IS F
Sbjct: 1175 RGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARISSAF 1234
Query: 3640 FRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVAL 3819
FRLFRVMRL+KLLSR EG+RTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL
Sbjct: 1235 FRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIAL 1294
Query: 3820 DDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNE 3999
D T I+RNNNF +FP A+L+LFR ATGEAWQ+I+L+CS + CDP SD Y G E
Sbjct: 1295 VDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGK--LCDPESD-YAPG--EE 1349
Query: 4000 SRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEY 4179
CG NFAY YFISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF +W+EY
Sbjct: 1350 YTCGTNFAYYYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAEY 1409
Query: 4180 DPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFA 4359
DP+AKGRIKHLDVVTLLR+I PPLGFGK CPHR+ACKRLV MNMPLNSDGTV FNATLFA
Sbjct: 1410 DPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFA 1469
Query: 4360 LVRTNLKIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFL 4539
LVRT LKI TEGN ++ANE+LR+ IK+IWKRT LLD+V+PP G +D+VTVGKFYATFL
Sbjct: 1470 LVRTALKIKTEGNFEQANEELRAIIKKIWKRTSMKLLDQVIPPIG-DDEVTVGKFYATFL 1528
Query: 4540 IQDYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTL-HEIGPELKRAISGNLETD 4704
IQ++FR+F KR+E E G P + + +QAGLRT+ E PE++R ISG+L +
Sbjct: 1529 IQEHFRKFMKRQE-EYYGYRPKK--DTVQIQAGLRTIEEEAAPEIRRTISGDLTAE 1581
Score = 674 bits (1739), Expect = 0.0
Identities = 357/687 (51%), Positives = 448/687 (64%), Gaps = 17/687 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
KK+P +KPL + V+ NP+RK CISIVEWKPFE +IL I ANC+AL
Sbjct: 13 KKQP--KKPLPE--VLPRPPRALFCLTLQNPLRKACISIVEWKPFETIILLTIFANCVAL 68
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A+Y P P D++ N LE +EY F+ VF+IE +KI+A GF+FH AYLR+ WN+LDFI
Sbjct: 69 AVYLPMPEDDNNSLNLGLEKLEYFFLTVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFI 128
Query: 496 IVVIGLVSTILSKMSI------------QGFDVKALRAFRVLRPLRLVSGVPSLQVVLNA 639
IV +G+ + IL ++++ G DVKALRAFRVLRPLRLVSGVPSLQVVLN+
Sbjct: 129 IVFLGVFTAILEQVNVIQSNTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNS 188
Query: 640 ILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLA---QKDPTPCGTD 810
I +AM+PL HIALLVLF+++IYAIIGLELF GK+H TC T +A + P+PC
Sbjct: 189 IFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYYIGTDIVATVENEKPSPCART 248
Query: 811 TEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTD 990
GS C + S EC WPGPN+GIT+FDNFG +MLTV+QC+++EGWTD
Sbjct: 249 --GSGRPCTINGS--------ECRGG--WPGPNHGITHFDNFGFSMLTVYQCITMEGWTD 296
Query: 991 VMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREK 1170
V+YWVNDA+G EWPWIYFVTL++LGSFF+LNLVLGVLSGEF+KEREKA++RG FQK REK
Sbjct: 297 VLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREK 356
Query: 1171 QQLEEDLKGYLDWITQAE--DIEPVNEDEQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKW 1344
QQLEEDL+GY+ WITQ E D+E + E + E +K
Sbjct: 357 QQLEEDLRGYMSWITQGEVMDVEDLREGKLSLEEGGSDTESLYEIEGL---------NKI 407
Query: 1345 AARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMA 1524
++ + N LVKS+ FYW SEH+ Q WL H Q +A
Sbjct: 408 IQFIRHWRQWNRVFRWKCHDLVKSRVFYWLVILIVALNTLSIASEHHNQPLWLTHLQDIA 467
Query: 1525 NLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVL 1704
N + LF++EMLLKMY LG Y S FNRFDCFVV S ILE +LV M PLG+SVL
Sbjct: 468 NRVLLSLFTIEMLLKMYGLGLRQYFMSIFNRFDCFVVCSGILELLLVESGAMTPLGISVL 527
Query: 1705 RSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNF 1884
R RLLR+FK+TKYWT GMQ+FGG+++F
Sbjct: 528 RCIRLLRLFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIIIFALLGMQLFGGRYDF 587
Query: 1885 NPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFI 2064
+ + R+NFD F QAL++VFQ+LTGEDWN+VMY+GI ++GG GV+VCIY+I+LF+
Sbjct: 588 EDTEVR-RSNFDNFPQALISVFQVLTGEDWNSVMYNGIMAYGGPSYPGVLVCIYFIILFV 646
Query: 2065 CGNYILLNVFLAIAVDNLADADSLTNA 2145
CGNYILLNVFLAIAVDNLA+A+SLT+A
Sbjct: 647 CGNYILLNVFLAIAVDNLAEAESLTSA 673
Score = 171 bits (432), Expect = 2e-40
Identities = 154/671 (22%), Positives = 283/671 (41%), Gaps = 73/671 (10%)
Frame = +1
Query: 2308 KPIPKA-----SSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQA- 2469
KP+P+ +LF L+ N R C +V F +L I + LA P+
Sbjct: 18 KPLPEVLPRPPRALFCLTLQNPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPED 77
Query: 2470 -NSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSF 2646
N++ N+ L +YFF +VF++E +K+I +G +FH+ ++ R+ +N+LD ++V + + +
Sbjct: 78 DNNSLNLGLEKLEYFFLTVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFIIVFLGVFTA 137
Query: 2647 VLR--------TDAMSXXXXXXXXXXXXXXXAINRAK------GLKHVVQCVIVAVKTIG 2784
+L T MS + + L+ V+ + A+ +
Sbjct: 138 ILEQVNVIQSNTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLF 197
Query: 2785 NIMLVTFMLQFMFAIIGVQLFKGT-----FFLCNDLSKMTEAECRGEYIHYEDGDP-TKP 2946
+I L+ + ++AIIG++LFKG +++ D+ E E G P T
Sbjct: 198 HIALLVLFMVIIYAIIGLELFKGKMHKTCYYIGTDIVATVENEKPSPCARTGSGRPCTIN 257
Query: 2947 VSKKRV-WSNNDF---NFDNVGDAMISLFVVSTFEG---------------WPQLLYVAI 3069
S+ R W + +FDN G +M++++ T EG WP + +V +
Sbjct: 258 GSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEWPWIYFVTL 317
Query: 3070 D-------------------SNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVI 3192
+ E +K + Q + +
Sbjct: 318 ILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLEEDLRGYMSWITQGEVMD 377
Query: 3193 VTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPR-NRL-QYRVWWFVTSRAFEYV 3366
V EG+ E D IE K R+ + NR+ +++ V SR F ++
Sbjct: 378 VEDLREGKLSLEEGGSDTESLYEIEGLNKIIQFIRHWRQWNRVFRWKCHDLVKSRVFYWL 437
Query: 3367 IFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWN 3546
+ LI+ +NT+S+A +H+ D+ N + +F E +LK+ L + Y +N
Sbjct: 438 VILIVALNTLSIASEHHNQPLWLTHLQDIANRVLLSLFTIEMLLKMYGLGLRQYFMSIFN 497
Query: 3547 VFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKS 3726
FD VV +++ + G + I+ R R++RL K+ + L+ + + S
Sbjct: 498 RFDCFVVCSGILELLL--VESGAMTPLGISVLRCIRLLRLFKITKYWTSLSNLVASLLNS 555
Query: 3727 FQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGE 3906
+++ + LL+ L I+A++GMQ FG + T + R+N F +FP A++ +F+ TGE
Sbjct: 556 IRSIASLLLLLFLFIIIFALLGMQLFGGRYDFEDTEVRRSN-FDNFPQALISVFQVLTGE 614
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP------YFISFFMLCSFLV 4068
W +M N +YP YFI F+ ++++
Sbjct: 615 DWNSVMY----------------------NGIMAYGGPSYPGVLVCIYFIILFVCGNYIL 652
Query: 4069 INLFVAVIMDN 4101
+N+F+A+ +DN
Sbjct: 653 LNVFLAIAVDN 663
Score = 120 bits (301), Expect = 4e-25
Identities = 99/343 (28%), Positives = 156/343 (44%), Gaps = 12/343 (3%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V N +R LC IV F IL I + AL
Sbjct: 757 RPRPLAELQLKEKAVPIPEASSFFIFSPTNKVRVLCHRIVNATWFTNFILLFILLSSAAL 816
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P A+ +N +L + F VFT+E VLK+ G H ++ RN +NILD +
Sbjct: 817 AAEDPIRAES--VRNQILGYFDIAFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNILDLL 874
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S L +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 875 VVAVSLISMGLESSTIS--VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIV 932
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLT 855
L+ + ++A IG++LF GK S C D L++ C G + + D T
Sbjct: 933 LVTTLLQFMFACIGVQLFKGKFFS-CND-----LSKMTEEEC----RGYYYVYKDGDP-T 981
Query: 856 NMGVRWECSSNTTWPGPNNGITN---FDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGRE 1026
M +R P I N FDN AM+++F + EGW ++Y D+ +
Sbjct: 982 QMELR-----------PRQWIHNDFHFDNVLSAMMSLFTVSTFEGWPQLLYRAIDSNEED 1030
Query: 1027 WPWIY---------FVTLVILGSFFVLNLVLGVLSGEFSKERE 1128
+Y F+ +IL +FF++N+ +G + F ++ E
Sbjct: 1031 MGPVYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGE 1073
Score = 87.4 bits (215), Expect = 4e-15
Identities = 77/336 (22%), Positives = 140/336 (40%), Gaps = 39/336 (11%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP + +V FE+L+ +I N I L + Q Y S+ N + + + F ++F
Sbjct: 1105 NPYQYQVWYVVTSSYFEYLMFALIMLNTICLGM-QHY--HQSEEMNHISDILNVAFTIIF 1161
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKM-----SIQGF----- 552
T+E +LK++A F Y + WN+ DF+IV+ ++ ILS++ S G
Sbjct: 1162 TLEMILKLLA----FKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGG 1217
Query: 553 -------DVKA------LRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFV 693
D A R FRV+R ++L+S ++ +L +++ L ++ALL++ +
Sbjct: 1218 GCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVML 1277
Query: 694 ILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRW 873
IYA+IG+++F G++A D T
Sbjct: 1278 FFIYAVIGMQMF-------------GKIALVDGTQI------------------------ 1300
Query: 874 ECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVN--------------- 1008
N NF F A+L +F+C + E W +++ +
Sbjct: 1301 ------------NRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGE 1348
Query: 1009 -DAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
G + + YF++ +L +F ++NL + V+ F
Sbjct: 1349 EYTCGTNFAYYYFISFYMLCAFLIINLFVAVIMDNF 1384
Score = 75.9 bits (185), Expect = 1e-11
Identities = 69/309 (22%), Positives = 127/309 (40%), Gaps = 57/309 (18%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDV----FNLIFTGVFAFEAVLKIVA-- 3510
+ FE +I L I N V+LA + P + L++ F VF+ EA +KI+A
Sbjct: 51 KPFETIILLTIFANCVALAV-YLPMPEDDNNSLNLGLEKLEYFFLTVFSIEAAMKIIAYG 109
Query: 3511 --LNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNL---------ISINFFRLFRV 3657
+ Y+ WNV D ++V ++N +N + + R FRV
Sbjct: 110 FLFHQDAYLRSGWNVLDFIIVFLGVFTAILEQVNVIQSNTAPMSSKGAGLDVKALRAFRV 169
Query: 3658 MRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GK-------V 3813
+R ++L+S ++ +L + K+ L ++ALL++ + IYA+IG++ F GK +
Sbjct: 170 LRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYYI 229
Query: 3814 ALDDSTSI--------------------------------HRNNNFHSFPAAILVLFRSA 3897
D ++ H +F +F ++L +++
Sbjct: 230 GTDIVATVENEKPSPCARTGSGRPCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCI 289
Query: 3898 TGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINL 4077
T E W D++ +D GN + + YF++ +L SF ++NL
Sbjct: 290 TMEGWTDVLYWVNDA---------------------IGNEWPWIYFVTLILLGSFFILNL 328
Query: 4078 FVAVIMDNF 4104
+ V+ F
Sbjct: 329 VLGVLSGEF 337
Score = 73.9 bits (180), Expect = 4e-11
Identities = 58/247 (23%), Positives = 98/247 (39%), Gaps = 34/247 (13%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HY QSE ++H + N+ F I+F++EM+LK+ + Y +N FD +VI SI++
Sbjct: 1138 QHYHQSEEMNHISDILNVAFTIIFTLEMILKLLAFKARGYFGDPWNVFDFLIVIGSIIDV 1197
Query: 1657 VLVYFDLM----------------------KPLGVSVLRSARLLRIFKVTKYWTXXXXXX 1770
+L D + + R R++R+ K+
Sbjct: 1198 ILSEIDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLL 1257
Query: 1771 XXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVF 1950
GMQ+FG + Q NF TF QA+L +F
Sbjct: 1258 WTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLF 1317
Query: 1951 QILTGEDWNTVMY----------HGIESFGGVGTLGVIVCIYYIVLF--ICGNYILLNVF 2094
+ TGE W ++ + G T G YY + F +C ++++N+F
Sbjct: 1318 RCATGEAWQEILLACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCA-FLIINLF 1376
Query: 2095 LAIAVDN 2115
+A+ +DN
Sbjct: 1377 VAVIMDN 1383
Score = 49.7 bits (117), Expect = 8e-04
Identities = 44/156 (28%), Positives = 74/156 (47%), Gaps = 40/156 (25%)
Frame = +1
Query: 919 TNFDNFGLAMLTVFQCVSLEGWTDVMY-WVNDAVGREWP----WIYFVTLVILGSFFVLN 1083
+NFDNF A+++VFQ ++ E W VMY + G +P IYF+ L + G++ +LN
Sbjct: 595 SNFDNFPQALISVFQVLTGEDWNSVMYNGIMAYGGPSYPGVLVCIYFIILFVCGNYILLN 654
Query: 1084 LVLGV-----------LSGEFSKEREKAR---ARGLFQKFREK-----QQLEEDLKG--- 1197
+ L + S + +K E+ R +RGL K E+ ++LE+ KG
Sbjct: 655 VFLAIAVDNLAEAESLTSAQKAKAEERKRRKMSRGLPDKTEEEKSVMAKKLEQKPKGEGI 714
Query: 1198 ----------YLDWITQAEDIEPVNE---DEQEDEP 1266
+ + + +D P + D++EDEP
Sbjct: 715 PTTAKLKVDEFESNVNEVKDPYPSADFPGDDEEDEP 750
Score = 42.7 bits (99), Expect = 0.10
Identities = 47/233 (20%), Positives = 89/233 (38%), Gaps = 38/233 (16%)
Frame = +1
Query: 1525 NLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLG 1692
++ F +F++E++LKM + G ++ + FN D VV S++ L +
Sbjct: 836 DIAFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNILDLLVVAVSLISMGLESSTISV--- 892
Query: 1693 VSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGG 1872
V +LR R+LR + G+Q+F G
Sbjct: 893 VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVLVTTLLQFMFACIGVQLFKG 952
Query: 1873 KF----------------------NFNPQQPKPRA--------NFDTFVQALLTVFQILT 1962
KF + +P Q + R +FD + A++++F + T
Sbjct: 953 KFFSCNDLSKMTEEECRGYYYVYKDGDPTQMELRPRQWIHNDFHFDNVLSAMMSLFTVST 1012
Query: 1963 GEDWNTVMYHGIES----FGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
E W ++Y I+S G V V + I++I+ I + ++N+F+ +
Sbjct: 1013 FEGWPQLLYRAIDSNEEDMGPVYNNRVEMAIFFIIYIILIAFFMMNIFVGFVI 1065
>gi|16758518|ref|NP_446153.1| calcium channel, voltage-dependent,
alpha 1F subunit [Rattus norvegicus]
gi|14669577|gb|AAK71987.1| alpha 1F calcium channel subunit [Rattus
norvegicus]
Length = 1981
Score = 1002 bits (2591), Expect = 0.0
Identities = 502/824 (60%), Positives = 629/824 (75%), Gaps = 10/824 (1%)
Frame = +1
Query: 2278 MSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAED 2457
+ EV V PIP+ S+ F LS TN R C+ +++H FT+ +L I++SS LAAED
Sbjct: 832 LQEVVPKEKVVPIPEGSAFFCLSQTNPLRKACHTLIHHHVFTSLILVFIILSSVSLAAED 891
Query: 2458 PLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSL 2637
P++A+S RN IL YFDY FTS+FTVEI LK+ VFG H+GSFCR+ FNLLD+LVV+VSL
Sbjct: 892 PIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFLHQGSFCRSWFNLLDLLVVSVSL 951
Query: 2638 TSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQF 2817
SF + + A+S AINRAKGLKHVVQCV VA++TIGNIM+VT +LQF
Sbjct: 952 ISFGIHSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQF 1011
Query: 2818 MFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNV 2997
MFA IGVQLFKG F+ C D +K T EC+G ++ Y DGD ++P+ ++R+W N+DFNFDNV
Sbjct: 1012 MFACIGVQLFKGKFYSCTDEAKHTLKECKGSFLIYPDGDVSRPLVRERLWVNSDFNFDNV 1071
Query: 2998 GDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXX 3177
AM++LF VSTFEGWP LLY AID++ ED+GPI+N +++
Sbjct: 1072 LSAMMALFTVSTFEGWPALLYKAIDAHAEDEGPIYNYHVEISVFFIVYIIIIAFFMMNIF 1131
Query: 3178 XGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVTSRAF 3357
GFVI+TF+ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N QYRVW V S AF
Sbjct: 1132 VGFVIITFRAQGEQEYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWATVNSAAF 1191
Query: 3358 EYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISD 3537
EY++FL+I++NTV+LA +HY + F +D+ N++FTG+F E VLKI+A PK+Y +D
Sbjct: 1192 EYLMFLLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTVEMVLKIIAFKPKHYFAD 1251
Query: 3538 RWNVFDLLVVVGSFIDITYGKLNPGG--------TNLISINFFRLFRVMRLVKLLSRGEG 3693
WN FD L+VVGS +DI ++N GG ++ ISI FFRLFRVMRLVKLLS+GEG
Sbjct: 1252 AWNTFDALIVVGSVVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLLSKGEG 1311
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAA 3873
IRTLLWTF+KSFQALP+VALLI ++FFIYAVIGMQ FGKVAL D T I+RNNNF +FP A
Sbjct: 1312 IRTLLWTFIKSFQALPHVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQA 1371
Query: 3874 ILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFML 4053
+L+LFR ATGEAWQ+IML+ RCDP SD G E CG+NFA YFISFFML
Sbjct: 1372 VLLLFRCATGEAWQEIMLASLPGN--RCDPESDF---GPGEEFTCGSNFAIVYFISFFML 1426
Query: 4054 CSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLR 4233
C+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+WSEYDP AKGRIKHLDVV LLR
Sbjct: 1427 CAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLR 1486
Query: 4234 KISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNIDEAN 4413
+I PPLGFGKLCPHR+ACKRLV+MN+PLNSDGTV FNATLFALVRT+L+I TEGN+D+AN
Sbjct: 1487 RIQPPLGFGKLCPHRVACKRLVAMNVPLNSDGTVTFNATLFALVRTSLRIKTEGNLDQAN 1546
Query: 4414 EQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEMEAKG 4593
++LR IK+IWKR + LLDEV+PP E++VTVGKFYATFLIQDYFR+F++RKE KG
Sbjct: 1547 QELRMVIKKIWKRIKQKLLDEVIPPP-DEEEVTVGKFYATFLIQDYFRKFRRRKE---KG 1602
Query: 4594 VLPAQTPQAMA--LQAGLRTLHEIGPELKRAISGNLETDFNFDE 4719
+L A P + + LQAGLR+L ++GPE+++A++ LE + +E
Sbjct: 1603 LLGADAPTSTSSVLQAGLRSLQDLGPEIRQALTYALEEEEEEEE 1646
Score = 445 bits (1145), Expect = e-123
Identities = 221/349 (63%), Positives = 269/349 (76%), Gaps = 12/349 (3%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR+ CISIVEWKPF+ LIL I ANC+AL +Y P+P DS+ LE +EYVF+V+F
Sbjct: 79 NPIRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTATHNLEQVEYVFLVIF 138
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQ------------ 546
T++ VLKIVA G + HPSAY+RN WN+LDFIIVV+GL S +L + +
Sbjct: 139 TVKTVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPG 198
Query: 547 GFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLEL 726
GFDVKALRAFRVLRPLRLVSGVPSL +VLN+I++A++PLLHIALLVLFVI+IYAIIGLEL
Sbjct: 199 GFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLEL 258
Query: 727 FCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGP 906
F G++H TC + A++DP+PC + GS C + + EC WPGP
Sbjct: 259 FLGRMHKTCYFLGSDMEAEEDPSPCASS--GSGRSCTLNQT--------ECRGR--WPGP 306
Query: 907 NNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNL 1086
N GITNFDNF AMLTVFQC+++EGWTDV+YW+ DA+G E PW+YFV+LVI GSFFVLNL
Sbjct: 307 NGGITNFDNFFFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNL 366
Query: 1087 VLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIE 1233
VLGVLSGEFSKEREKA+ARG FQK REKQQ+EEDL+GYLDWITQAE+++
Sbjct: 367 VLGVLSGEFSKEREKAKARGDFQKLREKQQMEEDLRGYLDWITQAEELD 415
Score = 241 bits (615), Expect = 1e-61
Identities = 126/242 (52%), Positives = 147/242 (60%)
Frame = +1
Query: 1408 VKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGF 1587
VKS YW SEH+GQ WL Q AN + LF++EMLLK+Y LG
Sbjct: 526 VKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQTQEYANKVLLCLFTVEMLLKLYGLGP 585
Query: 1588 TTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXX 1767
+ Y S FNRFDCFVV ILE LV M+PLG+SVLR RLLRIFKVT++W
Sbjct: 586 SVYVASFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASLSNL 645
Query: 1768 XXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTV 1947
GMQ+FGGKFNF+ K R+ FDTF QALLTV
Sbjct: 646 VASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTK-RSTFDTFPQALLTV 704
Query: 1948 FQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADA 2127
FQILTGEDWN VMY GI ++GG G++VC+Y+I+LFICGNYILLNVFLAIAVDNLA
Sbjct: 705 FQILTGEDWNVVMYDGIMAYGGPFFPGMLVCVYFIILFICGNYILLNVFLAIAVDNLASG 764
Query: 2128 DS 2133
D+
Sbjct: 765 DA 766
Score = 171 bits (433), Expect = 2e-40
Identities = 157/664 (23%), Positives = 280/664 (41%), Gaps = 33/664 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+RK C +++ F LIL I + ++LA P A ++N +L +Y F +F
Sbjct: 857 NPLRKACHTLIHHHVFTSLILVFIILSSVSLAAEDPIRAHS--FRNHILGYFDYAFTSIF 914
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
T+E +LK+ G H ++ R+ +N+LD ++V + L+S + +I VK LR RV
Sbjct: 915 TVEILLKMTVFGAFLHQGSFCRSWFNLLDLLVVSVSLISFGIHSSAIS--VVKILRVLRV 972
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLR ++ L+ V+ + A+ + +I ++ + ++A IG++LF GK +S C D
Sbjct: 973 LRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYS-CTDE 1031
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
A L + +GS F P ++ VR N+ + NFDN
Sbjct: 1032 AKHTL---------KECKGS-FLIYPDGDVSRPLVRERLWVNSDF--------NFDNVLS 1073
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIY---------FVTLVILGSFFVLNLVLG 1095
AM+ +F + EGW ++Y DA + IY F+ +I+ +FF++N+ +G
Sbjct: 1074 AMMALFTVSTFEGWPALLYKAIDAHAEDEGPIYNYHVEISVFFIVYIIIIAFFMMNIFVG 1133
Query: 1096 VLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIE---PVNEDEQEDEP 1266
+ F RA+G ++ + +L+++ + +++ +A+ + P N +
Sbjct: 1134 FVIITF-------RAQG--EQEYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYR--- 1181
Query: 1267 VAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXX 1446
WA V S F +
Sbjct: 1182 ------------------------VWAT-------------------VNSAAFEYLMFLL 1198
Query: 1447 XXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDC 1626
+HY Q+ ++ + N+ F LF++EM+LK+ + Y +N FD
Sbjct: 1199 ILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTVEMVLKIIAFKPKHYFADAWNTFDA 1258
Query: 1627 FVVISSILEFVLVYFDLMKPLG----------VSVLRSARLLRIFKVTKYWTXXXXXXXX 1776
+V+ S+++ + + LG ++ R R++R+ K+
Sbjct: 1259 LIVVGSVVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWT 1318
Query: 1777 XXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQI 1956
GMQ+FG + Q NF TF QA+L +F+
Sbjct: 1319 FIKSFQALPHVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRC 1378
Query: 1957 LTGEDWNTVMYHGI-------ESFGGVG---TLGV-IVCIYYIVLFICGNYILLNVFLAI 2103
TGE W +M + ES G G T G +Y+I F+ ++++N+F+A+
Sbjct: 1379 ATGEAWQEIMLASLPGNRCDPESDFGPGEEFTCGSNFAIVYFISFFMLCAFLIINLFVAV 1438
Query: 2104 AVDN 2115
+DN
Sbjct: 1439 IMDN 1442
Score = 108 bits (271), Expect = 1e-21
Identities = 77/301 (25%), Positives = 142/301 (46%), Gaps = 1/301 (0%)
Frame = +1
Query: 3202 QNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR-LQYRVWWFVTSRAFEYVIFLI 3378
++E E +C L C+ +K K R + NR L+ R V S A + + L+
Sbjct: 485 EDEEEGTMASCTL------CLNKIMKTKVCRHFRRANRGLRARCRRAVKSNACYWAVLLL 538
Query: 3379 IVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDL 3558
+ +NT+++A +H+ + N + +F E +LK+ L P Y++ +N FD
Sbjct: 539 VFLNTLTIASEHHGQPVWLTQTQEYANKVLLCLFTVEMLLKLYGLGPSVYVASFFNRFDC 598
Query: 3559 LVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQAL 3738
VV G ++ T ++ G + I+ R R++R+ K+ + L+ + + S +++
Sbjct: 599 FVVCGGILETTLVEV--GAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKSI 656
Query: 3739 PYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQD 3918
+ LL+ L I++++GMQ FG D T R + F +FP A+L +F+ TGE W
Sbjct: 657 ASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKR-STFDTFPQALLTVFQILTGEDWNV 715
Query: 3919 IMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMD 4098
+M + G L YFI F+ +++++N+F+A+ +D
Sbjct: 716 VMYD-------GIMAYGGPFFPGML---------VCVYFIILFICGNYILLNVFLAIAVD 759
Query: 4099 N 4101
N
Sbjct: 760 N 760
Score = 86.7 bits (213), Expect = 6e-15
Identities = 137/691 (19%), Positives = 245/691 (34%), Gaps = 61/691 (8%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIY---QP-YPAQDSDYKNTLLETIEYV 387
N +R C V+ + +L ++ N + +A QP + Q +Y N +L
Sbjct: 515 NRGLRARCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQTQEYANKVL------ 568
Query: 388 FIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKM-SIQGFDVKA 564
+ +FT+E +LK+ +G PS Y+ + +N D +V G++ T L ++ ++Q +
Sbjct: 569 -LCLFTVEMLLKLYGLG----PSVYVASFFNRFDCFVVCGGILETTLVEVGAMQPLGISV 623
Query: 565 LRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLH 744
LR R+LR ++ SL ++ ++L +M IA L+L + L I L
Sbjct: 624 LRCVRLLRIFKVTRHWASLSNLVASLLNSM---KSIASLLLLLFLFIIIFSL-------- 672
Query: 745 STCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITN 924
G G F + + +
Sbjct: 673 ------------------LGMQLFGGKFNFDQTHTKRS---------------------T 693
Query: 925 FDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREW-----PWIYFVTLVILGSFFVLNLV 1089
FD F A+LTVFQ ++ E W VMY A G + +YF+ L I G++ +LN+
Sbjct: 694 FDTFPQALLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCVYFIILFICGNYILLNVF 753
Query: 1090 LGV-----LSGEFSKEREKARARGLFQKFREKQQL------EEDLKGYLDWITQAEDIEP 1236
L + SG+ ++K R + ++ ++ ED +G T++E P
Sbjct: 754 LAIAVDNLASGDAGAAKDKGREKSSEGNPPQENKVLVPGGENEDTEG-----TKSEGAAP 808
Query: 1237 --VNEDEQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLV 1410
E+E+E+E + P + L + N +
Sbjct: 809 GMEEEEEEEEEEEEENGAGHVELLQEVVPKEKVVPIPEGSAFFCLSQTNPLRKACHTLIH 868
Query: 1411 KSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGF- 1587
+ + +H + F +F++E+LLKM G
Sbjct: 869 HHVFTSLILVFIILSSVSLAAEDPIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAF 928
Query: 1588 ---TTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXX 1758
++ S FN D VV S++ F + + V +LR R+LR +
Sbjct: 929 LHQGSFCRSWFNLLDLLVVSVSLISFGIHSSAISV---VKILRVLRVLRPLRAINRAKGL 985
Query: 1759 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRA--------- 1911
G+Q+F GKF + K
Sbjct: 986 KHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYSCTDEAKHTLKECKGSFLI 1045
Query: 1912 ---------------------NFDTFVQALLTVFQILTGEDWNTVMYHGI----ESFGGV 2016
NFD + A++ +F + T E W ++Y I E G +
Sbjct: 1046 YPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDAHAEDEGPI 1105
Query: 2017 GTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
V + +++IV I + ++N+F+ +
Sbjct: 1106 YNYHVEISVFFIVYIIIIAFFMMNIFVGFVI 1136
Score = 85.1 bits (209), Expect = 2e-14
Identities = 74/275 (26%), Positives = 111/275 (39%), Gaps = 31/275 (11%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN--STRNMILNYF 2502
+LF L+ TN R C +V F +L I + L P + +T L
Sbjct: 71 ALFCLTLTNPIRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTATHNLEQV 130
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL---------- 2652
+Y F +FTV+ LK++ +GLV H ++ RN +NLLD ++V V L S +L
Sbjct: 131 EYVFLVIFTVKTVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDA 190
Query: 2653 -RTDAMSXXXXXXXXXXXXXXXAINRAKG---LKHVVQCVIVAVKTIGNIMLVTFMLQFM 2820
T + G L V+ ++ A+ + +I L+ + +
Sbjct: 191 PHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIII 250
Query: 2821 FAIIGVQLFKGTFF-LCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNND------ 2979
+AIIG++LF G C L EAE ED P R + N
Sbjct: 251 YAIIGLELFLGRMHKTCYFLGSDMEAE--------EDPSPCASSGSGRSCTLNQTECRGR 302
Query: 2980 --------FNFDNVGDAMISLFVVSTFEGWPQLLY 3060
NFDN AM+++F T EGW +LY
Sbjct: 303 WPGPNGGITNFDNFFFAMLTVFQCITMEGWTDVLY 337
Score = 79.3 bits (194), Expect = 1e-12
Identities = 79/310 (25%), Positives = 130/310 (41%), Gaps = 58/310 (18%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ F+ +I L I N V+L +P S L+ +F +F + VLKIVA
Sbjct: 92 KPFDILILLTIFANCVALGVYIPFPEDDSNTATHNLEQVEYVFLVIFTVKTVLKIVAYGL 151
Query: 3511 -LNPKNYISDRWNVFDLLVVVGSFIDI--------------TYGKLNPGGTNLISINFFR 3645
L+P YI + WN+ D ++VV + T GK PGG + R
Sbjct: 152 VLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGK--PGG---FDVKALR 206
Query: 3646 LFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV--- 3813
FRV+R ++L+S + +L + MK+ L ++ALL++ + IYA+IG++ F G++
Sbjct: 207 AFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKT 266
Query: 3814 ---------ALDD-----------STSIHRN-------------NNFHSFPAAILVLFRS 3894
A +D S ++++ NF +F A+L +F+
Sbjct: 267 CYFLGSDMEAEEDPSPCASSGSGRSCTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQC 326
Query: 3895 ATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVIN 4074
T E W D++ D G + YF+S + SF V+N
Sbjct: 327 ITMEGWTDVLYWMQD---------------------AMGYELPWVYFVSLVIFGSFFVLN 365
Query: 4075 LFVAVIMDNF 4104
L + V+ F
Sbjct: 366 LVLGVLSGEF 375
Score = 45.1 bits (105), Expect = 0.020
Identities = 23/64 (35%), Positives = 37/64 (56%)
Frame = +1
Query: 1912 NFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNV 2091
NFD F A+LTVFQ +T E W V+Y ++ G + +Y++ L I G++ +LN+
Sbjct: 312 NFDNFFFAMLTVFQCITMEGWTDVLYWMQDAMG-----YELPWVYFVSLVIFGSFFVLNL 366
Query: 2092 FLAI 2103
L +
Sbjct: 367 VLGV 370
>gi|6751840|dbj|BAA34927.2| ascidian calcium channel alpha1-subunit
[Halocynthia roretzi]
Length = 2125
Score = 999 bits (2583), Expect = 0.0
Identities = 519/941 (55%), Positives = 654/941 (69%), Gaps = 16/941 (1%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPRRMSE+ + P+P+ SS FILS+TN RVFC +VN+++F NA+L CI++SS L
Sbjct: 762 RPRRMSEMHLSEKKVPLPEGSSFFILSNTNRLRVFCYDIVNYNWFNNAILACIILSSIAL 821
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
A EDP+ A+S RN +L YFDY FT VF VEI LK+ FG+ HKGSFCR+ FNLLD+LVV
Sbjct: 822 ACEDPVSAHSARNKVLEYFDYVFTGVFAVEIVLKMTAFGVFLHKGSFCRSYFNLLDLLVV 881
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXX-XXAINRAKGLKHVVQCVIVAVKTIGNIMLVT 2802
AVSL S + +D S AINRAKGLKHVVQCV VA+ TIGNIM++T
Sbjct: 882 AVSLVSMLSNSDKFSVVKILRVLPSVLRPLRAINRAKGLKHVVQCVFVAISTIGNIMVIT 941
Query: 2803 FMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDF 2982
+LQFMFA IGVQLFKG + C D SK T+ EC G++ Y +P ++R+W N++F
Sbjct: 942 GLLQFMFACIGVQLFKGRLYYCTDQSKETKEECHGKFFVYSKDGNGEPRVEERLWENSEF 1001
Query: 2983 NFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXX 3162
N+DNV +AM++LFVV+TFEGWP LLY +IDS E+ GP +++RQAVAL
Sbjct: 1002 NYDNVMNAMLTLFVVATFEGWPGLLYKSIDSWSENHGPRYDARQAVALFYFVFIIVIAFF 1061
Query: 3163 XXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFV 3342
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKAKP +RYIP+N QY+VW+ V
Sbjct: 1062 MMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCLEYALKAKPVKRYIPKNPWQYKVWFIV 1121
Query: 3343 TSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPK 3522
S FEY + ++I++NTV LA +H+ S+ L+ N +FT +FA E ++K+VA P+
Sbjct: 1122 NSTYFEYFMLVLILLNTVCLAVQHHQQSKELTVILNHMNYVFTALFALEMIVKLVAYKPR 1181
Query: 3523 NYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRT 3702
Y+SD WNVFD L+V+GS +DI + +L+ G SINFFRLFRV+RLVKLLSRGEGIRT
Sbjct: 1182 GYLSDPWNVFDSLIVIGSIVDIVFSELDHGNEKSFSINFFRLFRVLRLVKLLSRGEGIRT 1241
Query: 3703 LLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILV 3882
LLWTF+KSF ALPYVALLI++LFFIYAVIGMQ FGK+ +D + I+RNNNF +F A+L+
Sbjct: 1242 LLWTFIKSFPALPYVALLIIMLFFIYAVIGMQIFGKIKPNDGSQINRNNNFQTFLQAVLL 1301
Query: 3883 LFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNES---RCGNNFAYPYFISFFML 4053
LFR ATGE+WQ++ML+C+ + CD SD + G + S CGN+FAY YF++F+ML
Sbjct: 1302 LFRCATGESWQEVMLACASGNE--CDDESDWNYYGDKDISAKFTCGNDFAYTYFLTFYML 1359
Query: 4054 CSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLR 4233
C+FL+INLFVAVIMDNFDYLTRDWSILG HHL+EFVR+WSEYD +A GRIKHL VV LLR
Sbjct: 1360 CAFLIINLFVAVIMDNFDYLTRDWSILGLHHLDEFVRVWSEYDHEASGRIKHLHVVKLLR 1419
Query: 4234 KISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNIDEAN 4413
I PPLGFGKLCP R+AC++LVSMNMPLNSDGTV FNATLFALVRT+LKI +EGNID+AN
Sbjct: 1420 HIQPPLGFGKLCPQRMACRKLVSMNMPLNSDGTVMFNATLFALVRTSLKIKSEGNIDQAN 1479
Query: 4414 EQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKE---ME 4584
E+LR+ IK+IWKRT LLD+VVPPAG DDVTVGKFYAT+LIQDYFR+FK+ KE E
Sbjct: 1480 EELRAVIKKIWKRTSMKLLDQVVPPAG-NDDVTVGKFYATYLIQDYFRKFKESKERRLRE 1538
Query: 4585 AKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNL------ETDFNFDEPEPQHRRPH 4746
G + LQAG+R + ++ PELKR+ISGNL E++ + EP+HRR H
Sbjct: 1539 RDGRHHPNNANTLTLQAGIREVQDVSPELKRSISGNLVPNEYEESELVSMDDEPEHRRRH 1598
Query: 4747 SLFNNLVHRLSGAGSKSPTEHERIEKGSTLLPFQPRSFSPTHSLAGAEGSPVPSQMHRGA 4926
S+F L L+ G+ T + R P Q A
Sbjct: 1599 SIFGQL-RSLASPGTPVMTSRRPLTVSDNTPAVGHRKHEQNSDQNPLVNRLTPQQPFPNA 1657
Query: 4927 -PINQSINLPPVNGSARRLPALPPYAN--HIHDETDDGPRY 5040
P + VN S + +P AN H DD RY
Sbjct: 1658 TPSHAQATEKSVNRSLDGIHTMPRDANIGRHHGSIDDFSRY 1698
Score = 675 bits (1742), Expect = 0.0
Identities = 341/646 (52%), Positives = 432/646 (66%), Gaps = 8/646 (1%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIRK C+ IV+W+PF+ LIL I ANC+ALA+Y P+P DS+ N +LE +EY+F+ +F
Sbjct: 34 NPIRKACMKIVDWRPFDVLILLTILANCVALAVYVPFPGDDSNRTNEILEKVEYIFLGIF 93
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD-VKALRAFR 579
TIE +LKI+A G FHP+AYLRN WN++DF+IVVIGLVS +L ++ D V++LRAFR
Sbjct: 94 TIEAILKIIAYGLFFHPNAYLRNGWNVIDFVIVVIGLVSIVLETANVGSTDKVRSLRAFR 153
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPLRLVSGVPSL+VVLNAI+RAM+PLLHIALLV+FVI+IYA++GLELF GKLH TC
Sbjct: 154 VLRPLRLVSGVPSLEVVLNAIIRAMVPLLHIALLVIFVIIIYAVVGLELFKGKLHKTCYH 213
Query: 760 PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFG 939
L +D D++ C C S+ W GP+ GI NFD F
Sbjct: 214 NEVAVLIMEDEAKPCADSDSWGRHCSGG---------MICESD--WAGPSKGIINFDTFY 262
Query: 940 LAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSK 1119
A++TVFQC+++EGWTDV+Y++NDAVG WPWIYFV+L+I+GSFFV+NL+LGVLSGEFSK
Sbjct: 263 FAVITVFQCITMEGWTDVLYYMNDAVGNLWPWIYFVSLIIIGSFFVMNLILGVLSGEFSK 322
Query: 1120 EREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVAQTXXXXXXX 1299
EREKA ARG FQK REKQQ +ED+KGY+DWITQAED++P+N++++ED A
Sbjct: 323 EREKANARGEFQKLREKQQTDEDMKGYMDWITQAEDLDPMNDEDREDRRSASNEQLNDAD 382
Query: 1300 XXXXXXXXXXXPSKWAAR-------MKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXX 1458
+ R +R + N +VKS++FYW
Sbjct: 383 SEVSGLQIDETWWQMQRRALFKVCYSRRWRRWNRKTRRRCRTMVKSKSFYWLVIVLVFCN 442
Query: 1459 XXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVI 1638
+EHY Q WL Q +AN + LF++EML+KMYSLG Y S FNRFDCFVV
Sbjct: 443 TLSLATEHYRQPPWLTLAQDLANKILLTLFTIEMLVKMYSLGMQQYFVSLFNRFDCFVVC 502
Query: 1639 SSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXX 1818
I+E VL +M+PLG+SVLR RLLRIFK+T W
Sbjct: 503 GGIVELVLTSSKIMEPLGISVLRCVRLLRIFKMTSSWNSLSNLVASLLNSIRSIASLLVL 562
Query: 1819 XXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGI 1998
GMQ+FGG+F+ Q+ K R+NFDTF+QALLTVFQILTGEDWN VMY+GI
Sbjct: 563 LFLFIIIFALLGMQMFGGRFSEIEQEDKIRSNFDTFLQALLTVFQILTGEDWNVVMYNGI 622
Query: 1999 ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSL 2136
E++GG T+G++ +Y+IVLFI GNYILLNVFLAIAVDNLADA+SL
Sbjct: 623 EAYGGASTIGLLTSVYFIVLFIGGNYILLNVFLAIAVDNLADAESL 668
Score = 113 bits (282), Expect = 6e-23
Identities = 93/337 (27%), Positives = 159/337 (46%), Gaps = 13/337 (3%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
N +R C IV + F IL I + IALA P A + +N +LE +YVF VF
Sbjct: 791 NRLRVFCYDIVNYNWFNNAILACIILSSIALACEDPVSAHSA--RNKVLEYFDYVFTGVF 848
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILS--KMSIQGFDVKALRAF 576
+E VLK+ A G H ++ R+ +N+LD ++V + LVS + + K S+ VK LR
Sbjct: 849 AVEIVLKMTAFGVFLHKGSFCRSYFNLLDLLVVAVSLVSMLSNSDKFSV----VKILRVL 904
Query: 577 -RVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTC 753
VLRPLR ++ L+ V+ + A+ + +I ++ + ++A IG++LF G+L+
Sbjct: 905 PSVLRPLRAINRAKGLKHVVQCVFVAISTIGNIMVITGLLQFMFACIGVQLFKGRLYY-- 962
Query: 754 IDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECS-SNTTWPGPNNGITNFD 930
C ++ + +C + + E W N N+D
Sbjct: 963 ---------------CTDQSKETKEECHGKFFVYSKDGNGEPRVEERLW---ENSEFNYD 1004
Query: 931 NFGLAMLTVFQCVSLEGWTDVMYWVNDA---------VGREWPWIYFVTLVILGSFFVLN 1083
N AMLT+F + EGW ++Y D+ R+ +++ +I+ +FF++N
Sbjct: 1005 NVMNAMLTLFVVATFEGWPGLLYKSIDSWSENHGPRYDARQAVALFYFVFIIVIAFFMMN 1064
Query: 1084 LVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLK 1194
+ +G + F ++ E+ K ++Q LE LK
Sbjct: 1065 IFVGFVIVTFQEQGEQEYKNCELDK-NQRQCLEYALK 1100
Score = 105 bits (262), Expect = 1e-20
Identities = 91/358 (25%), Positives = 155/358 (42%), Gaps = 45/358 (12%)
Frame = +1
Query: 3307 RNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGV 3477
+N ++ V R F+ +I L I+ N V+LA +P S + L+ IF G+
Sbjct: 33 KNPIRKACMKIVDWRPFDVLILLTILANCVALAVYVPFPGDDSNRTNEILEKVEYIFLGI 92
Query: 3478 FAFEAVLKIVA----LNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFR 3645
F EA+LKI+A +P Y+ + WNV D ++VV + I N G T+ + R
Sbjct: 93 FTIEAILKIIAYGLFFHPNAYLRNGWNVIDFVIVVIGLVSIVLETANVGSTD--KVRSLR 150
Query: 3646 LFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKV--- 3813
FRV+R ++L+S + +L +++ L ++ALL++ + IYAV+G++ F GK+
Sbjct: 151 AFRVLRPLRLVSGVPSLEVVLNAIIRAMVPLLHIALLVIFVIIIYAVVGLELFKGKLHKT 210
Query: 3814 ------------------ALDDSTSIHRNN----------------NFHSFPAAILVLFR 3891
A DS H + NF +F A++ +F+
Sbjct: 211 CYHNEVAVLIMEDEAKPCADSDSWGRHCSGGMICESDWAGPSKGIINFDTFYFAVITVFQ 270
Query: 3892 SATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVI 4071
T E W D++ +D GN + + YF+S ++ SF V+
Sbjct: 271 CITMEGWTDVLYYMND---------------------AVGNLWPWIYFVSLIIIGSFFVM 309
Query: 4072 NLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
NL + V+ F + G + +R + D D KG ++D +T + P
Sbjct: 310 NLILGVLSGEFSKEREKANARGEF---QKLREKQQTDEDMKG---YMDWITQAEDLDP 361
Score = 104 bits (260), Expect = 2e-20
Identities = 74/305 (24%), Positives = 147/305 (47%), Gaps = 6/305 (1%)
Frame = +1
Query: 3205 NEGEREYENCELDKN----QRKCIEFALKAKPHRRYIPRNRLQYRVWWFVTSRAFEYVIF 3372
N+ + E ++D+ QR+ + ++ RR+ + R + R V S++F +++
Sbjct: 379 NDADSEVSGLQIDETWWQMQRRALFKVCYSRRWRRWNRKTRRRCRT--MVKSKSFYWLVI 436
Query: 3373 LIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVF 3552
+++ NT+SLA +HY D+ N I +F E ++K+ +L + Y +N F
Sbjct: 437 VLVFCNTLSLATEHYRQPPWLTLAQDLANKILLTLFTIEMLVKMYSLGMQQYFVSLFNRF 496
Query: 3553 DLLVVVGSFIDI--TYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKS 3726
D VV G +++ T K+ + I+ R R++R+ K+ S + L+ + + S
Sbjct: 497 DCFVVCGGIVELVLTSSKI----MEPLGISVLRCVRLLRIFKMTSSWNSLSNLVASLLNS 552
Query: 3727 FQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGE 3906
+++ + +L+ L I+A++GMQ FG + +NF +F A+L +F+ TGE
Sbjct: 553 IRSIASLLVLLFLFIIIFALLGMQMFGGRFSEIEQEDKIRSNFDTFLQALLTVFQILTGE 612
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVA 4086
W +M + + GG + YFI F+ +++++N+F+A
Sbjct: 613 DWNVVMYNGIEA-------------YGGASTI---GLLTSVYFIVLFIGGNYILLNVFLA 656
Query: 4087 VIMDN 4101
+ +DN
Sbjct: 657 IAVDN 661
Score = 103 bits (257), Expect = 5e-20
Identities = 76/283 (26%), Positives = 121/283 (41%), Gaps = 26/283 (9%)
Frame = +1
Query: 2305 VKPIPKAS----SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN 2472
+KP P A +L LS N R C +V+ F +L IL + LA P +
Sbjct: 14 IKPDPNAGRAPQALLCLSLKNPIRKACMKIVDWRPFDVLILLTILANCVALAVYVPFPGD 73
Query: 2473 STR--NMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSF 2646
+ N IL +Y F +FT+E LK+I +GL FH ++ RN +N++D ++V + L S
Sbjct: 74 DSNRTNEILEKVEYIFLGIFTIEAILKIIAYGLFFHPNAYLRNGWNVIDFVIVVIGLVSI 133
Query: 2647 VLRTDAMSXXXXXXXXXXXXXXXAINRAKG---LKHVVQCVIVAVKTIGNIMLVTFMLQF 2817
VL T + + G L+ V+ +I A+ + +I L+ +
Sbjct: 134 VLETANVGSTDKVRSLRAFRVLRPLRLVSGVPSLEVVLNAIIRAMVPLLHIALLVIFVII 193
Query: 2818 MFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVW---------- 2967
++A++G++LFKG K+ + E D KP + W
Sbjct: 194 IYAVVGLELFKG---------KLHKTCYHNEVAVLIMEDEAKPCADSDSWGRHCSGGMIC 244
Query: 2968 -------SNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
S NFD A+I++F T EGW +LY D+
Sbjct: 245 ESDWAGPSKGIINFDTFYFAVITVFQCITMEGWTDVLYYMNDA 287
Score = 102 bits (253), Expect = 1e-19
Identities = 80/322 (24%), Positives = 141/322 (42%), Gaps = 25/322 (7%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP + IV FE+ +L +I N + LA+ Q S +L + YVF +F
Sbjct: 1111 NPWQYKVWFIVNSTYFEYFMLVLILLNTVCLAVQHH---QQSKELTVILNHMNYVFTALF 1167
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKM---SIQGFDVKALRA 573
+E ++K+VA + P YL + WN+ D +IV+ +V + S++ + + F + R
Sbjct: 1168 ALEMIVKLVA----YKPRGYLSDPWNVFDSLIVIGSIVDIVFSELDHGNEKSFSINFFRL 1223
Query: 574 FRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTC 753
FRVLR ++L+S ++ +L +++ L ++ALL++ + IYA+IG+++F GK+
Sbjct: 1224 FRVLRLVKLLSRGEGIRTLLWTFIKSFPALPYVALLIIMLFFIYAVIGMQIF-GKI---- 1278
Query: 754 IDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDN 933
+P+D N NF
Sbjct: 1279 ---------------------------KPNDG-----------------SQINRNNNFQT 1294
Query: 934 FGLAMLTVFQCVSLEGWTDVM-----------------YWVND-----AVGREWPWIYFV 1047
F A+L +F+C + E W +VM Y D G ++ + YF+
Sbjct: 1295 FLQAVLLLFRCATGESWQEVMLACASGNECDDESDWNYYGDKDISAKFTCGNDFAYTYFL 1354
Query: 1048 TLVILGSFFVLNLVLGVLSGEF 1113
T +L +F ++NL + V+ F
Sbjct: 1355 TFYMLCAFLIINLFVAVIMDNF 1376
Score = 76.6 bits (187), Expect = 6e-12
Identities = 57/232 (24%), Positives = 96/232 (40%), Gaps = 19/232 (8%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+H+ QS+ L N F LF++EM++K+ + Y + +N FD +VI SI++
Sbjct: 1144 QHHQQSKELTVILNHMNYVFTALFALEMIVKLVAYKPRGYLSDPWNVFDSLIVIGSIVDI 1203
Query: 1657 VLVYFD--LMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXX 1830
V D K ++ R R+LR+ K+
Sbjct: 1204 VFSELDHGNEKSFSINFFRLFRVLRLVKLLSRGEGIRTLLWTFIKSFPALPYVALLIIML 1263
Query: 1831 XXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVM-------- 1986
GMQ+FG + Q NF TF+QA+L +F+ TGE W VM
Sbjct: 1264 FFIYAVIGMQIFGKIKPNDGSQINRNNNFQTFLQAVLLLFRCATGESWQEVMLACASGNE 1323
Query: 1987 --------YHGIESFGGVGTLG-VIVCIYYIVLFICGNYILLNVFLAIAVDN 2115
Y+G + T G Y++ ++ ++++N+F+A+ +DN
Sbjct: 1324 CDDESDWNYYGDKDISAKFTCGNDFAYTYFLTFYMLCAFLIINLFVAVIMDN 1375
Score = 44.3 bits (103), Expect = 0.035
Identities = 56/254 (22%), Positives = 98/254 (38%), Gaps = 42/254 (16%)
Frame = +1
Query: 1474 SEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVIS 1641
S H +++ L++F + F +F++E++LKM + G ++ S FN D VV
Sbjct: 828 SAHSARNKVLEYFDYV----FTGVFAVEIVLKMTAFGVFLHKGSFCRSYFNLLDLLVVAV 883
Query: 1642 SILEFVLVY--FDLMKPLGV--SVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXX 1809
S++ + F ++K L V SVLR R + K K+
Sbjct: 884 SLVSMLSNSDKFSVVKILRVLPSVLRPLRAINRAKGLKH------VVQCVFVAISTIGNI 937
Query: 1810 XXXXXXXXXXXXXXGMQVFGGKFNFNPQQPK--------------------PRA------ 1911
G+Q+F G+ + Q K PR
Sbjct: 938 MVITGLLQFMFACIGVQLFKGRLYYCTDQSKETKEECHGKFFVYSKDGNGEPRVEERLWE 997
Query: 1912 ----NFDTFVQALLTVFQILTGEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFIC 2067
N+D + A+LT+F + T E W ++Y I+S+ G V ++Y V I
Sbjct: 998 NSEFNYDNVMNAMLTLFVVATFEGWPGLLYKSIDSWSENHGPRYDARQAVALFYFVFIIV 1057
Query: 2068 GNYILLNVFLAIAV 2109
+ ++N+F+ +
Sbjct: 1058 IAFFMMNIFVGFVI 1071
Score = 43.5 bits (101), Expect = 0.059
Identities = 46/244 (18%), Positives = 92/244 (36%), Gaps = 9/244 (3%)
Frame = +1
Query: 2371 CNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQ------ANSTRNMILNYFDYFFTSVFTV 2532
C +V F V+ + ++ LA E Q A N IL ++FT+
Sbjct: 422 CRTMVKSKSFYWLVIVLVFCNTLSLATEHYRQPPWLTLAQDLANKIL-------LTLFTI 474
Query: 2533 EITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXX 2712
E+ +K+ G+ + + FN D VV + VL + +
Sbjct: 475 EMLVKMYSLGMQ----QYFVSLFNRFDCFVVCGGIVELVLTSSKIMEPLGISVLRCVRLL 530
Query: 2713 XAINRAKG---LKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSK 2883
L ++V ++ ++++I +++++ F+ +FA++G+Q+F G F K
Sbjct: 531 RIFKMTSSWNSLSNLVASLLNSIRSIASLLVLLFLFIIIFALLGMQMFGGRFSEIEQEDK 590
Query: 2884 MTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYV 3063
+ NFD A++++F + T E W ++Y
Sbjct: 591 IRS------------------------------NFDTFLQALLTVFQILTGEDWNVVMYN 620
Query: 3064 AIDS 3075
I++
Sbjct: 621 GIEA 624
>gi|7512118|pir||T30890 calcium channel alpha1-chain - sea squirt
(Halocynthia roretzi)
Length = 2262
Score = 999 bits (2583), Expect = 0.0
Identities = 519/941 (55%), Positives = 654/941 (69%), Gaps = 16/941 (1%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPRRMSE+ + P+P+ SS FILS+TN RVFC +VN+++F NA+L CI++SS L
Sbjct: 899 RPRRMSEMHLSEKKVPLPEGSSFFILSNTNRLRVFCYDIVNYNWFNNAILACIILSSIAL 958
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
A EDP+ A+S RN +L YFDY FT VF VEI LK+ FG+ HKGSFCR+ FNLLD+LVV
Sbjct: 959 ACEDPVSAHSARNKVLEYFDYVFTGVFAVEIVLKMTAFGVFLHKGSFCRSYFNLLDLLVV 1018
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXX-XXAINRAKGLKHVVQCVIVAVKTIGNIMLVT 2802
AVSL S + +D S AINRAKGLKHVVQCV VA+ TIGNIM++T
Sbjct: 1019 AVSLVSMLSNSDKFSVVKILRVLPSVLRPLRAINRAKGLKHVVQCVFVAISTIGNIMVIT 1078
Query: 2803 FMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDF 2982
+LQFMFA IGVQLFKG + C D SK T+ EC G++ Y +P ++R+W N++F
Sbjct: 1079 GLLQFMFACIGVQLFKGRLYYCTDQSKETKEECHGKFFVYSKDGNGEPRVEERLWENSEF 1138
Query: 2983 NFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXX 3162
N+DNV +AM++LFVV+TFEGWP LLY +IDS E+ GP +++RQAVAL
Sbjct: 1139 NYDNVMNAMLTLFVVATFEGWPGLLYKSIDSWSENHGPRYDARQAVALFYFVFIIVIAFF 1198
Query: 3163 XXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFV 3342
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKAKP +RYIP+N QY+VW+ V
Sbjct: 1199 MMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCLEYALKAKPVKRYIPKNPWQYKVWFIV 1258
Query: 3343 TSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPK 3522
S FEY + ++I++NTV LA +H+ S+ L+ N +FT +FA E ++K+VA P+
Sbjct: 1259 NSTYFEYFMLVLILLNTVCLAVQHHQQSKELTVILNHMNYVFTALFALEMIVKLVAYKPR 1318
Query: 3523 NYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRT 3702
Y+SD WNVFD L+V+GS +DI + +L+ G SINFFRLFRV+RLVKLLSRGEGIRT
Sbjct: 1319 GYLSDPWNVFDSLIVIGSIVDIVFSELDHGNEKSFSINFFRLFRVLRLVKLLSRGEGIRT 1378
Query: 3703 LLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILV 3882
LLWTF+KSF ALPYVALLI++LFFIYAVIGMQ FGK+ +D + I+RNNNF +F A+L+
Sbjct: 1379 LLWTFIKSFPALPYVALLIIMLFFIYAVIGMQIFGKIKPNDGSQINRNNNFQTFLQAVLL 1438
Query: 3883 LFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNES---RCGNNFAYPYFISFFML 4053
LFR ATGE+WQ++ML+C+ + CD SD + G + S CGN+FAY YF++F+ML
Sbjct: 1439 LFRCATGESWQEVMLACASGNE--CDDESDWNYYGDKDISAKFTCGNDFAYTYFLTFYML 1496
Query: 4054 CSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLR 4233
C+FL+INLFVAVIMDNFDYLTRDWSILG HHL+EFVR+WSEYD +A GRIKHL VV LLR
Sbjct: 1497 CAFLIINLFVAVIMDNFDYLTRDWSILGLHHLDEFVRVWSEYDHEASGRIKHLHVVKLLR 1556
Query: 4234 KISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNIDEAN 4413
I PPLGFGKLCP R+AC++LVSMNMPLNSDGTV FNATLFALVRT+LKI +EGNID+AN
Sbjct: 1557 HIQPPLGFGKLCPQRMACRKLVSMNMPLNSDGTVMFNATLFALVRTSLKIKSEGNIDQAN 1616
Query: 4414 EQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKE---ME 4584
E+LR+ IK+IWKRT LLD+VVPPAG DDVTVGKFYAT+LIQDYFR+FK+ KE E
Sbjct: 1617 EELRAVIKKIWKRTSMKLLDQVVPPAG-NDDVTVGKFYATYLIQDYFRKFKESKERRLRE 1675
Query: 4585 AKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNL------ETDFNFDEPEPQHRRPH 4746
G + LQAG+R + ++ PELKR+ISGNL E++ + EP+HRR H
Sbjct: 1676 RDGRHHPNNANTLTLQAGIREVQDVSPELKRSISGNLVPNEYEESELVSMDDEPEHRRRH 1735
Query: 4747 SLFNNLVHRLSGAGSKSPTEHERIEKGSTLLPFQPRSFSPTHSLAGAEGSPVPSQMHRGA 4926
S+F L L+ G+ T + R P Q A
Sbjct: 1736 SIFGQL-RSLASPGTPVMTSRRPLTVSDNTPAVGHRKHEQNSDQNPLVNRLTPQQPFPNA 1794
Query: 4927 -PINQSINLPPVNGSARRLPALPPYAN--HIHDETDDGPRY 5040
P + VN S + +P AN H DD RY
Sbjct: 1795 TPSHAQATEKSVNRSLDGIHTMPRDANIGRHHGSIDDFSRY 1835
Score = 675 bits (1742), Expect = 0.0
Identities = 341/646 (52%), Positives = 432/646 (66%), Gaps = 8/646 (1%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIRK C+ IV+W+PF+ LIL I ANC+ALA+Y P+P DS+ N +LE +EY+F+ +F
Sbjct: 171 NPIRKACMKIVDWRPFDVLILLTILANCVALAVYVPFPGDDSNRTNEILEKVEYIFLGIF 230
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD-VKALRAFR 579
TIE +LKI+A G FHP+AYLRN WN++DF+IVVIGLVS +L ++ D V++LRAFR
Sbjct: 231 TIEAILKIIAYGLFFHPNAYLRNGWNVIDFVIVVIGLVSIVLETANVGSTDKVRSLRAFR 290
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPLRLVSGVPSL+VVLNAI+RAM+PLLHIALLV+FVI+IYA++GLELF GKLH TC
Sbjct: 291 VLRPLRLVSGVPSLEVVLNAIIRAMVPLLHIALLVIFVIIIYAVVGLELFKGKLHKTCYH 350
Query: 760 PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFG 939
L +D D++ C C S+ W GP+ GI NFD F
Sbjct: 351 NEVAVLIMEDEAKPCADSDSWGRHCSGG---------MICESD--WAGPSKGIINFDTFY 399
Query: 940 LAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSK 1119
A++TVFQC+++EGWTDV+Y++NDAVG WPWIYFV+L+I+GSFFV+NL+LGVLSGEFSK
Sbjct: 400 FAVITVFQCITMEGWTDVLYYMNDAVGNLWPWIYFVSLIIIGSFFVMNLILGVLSGEFSK 459
Query: 1120 EREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVAQTXXXXXXX 1299
EREKA ARG FQK REKQQ +ED+KGY+DWITQAED++P+N++++ED A
Sbjct: 460 EREKANARGEFQKLREKQQTDEDMKGYMDWITQAEDLDPMNDEDREDRRSASNEQLNDAD 519
Query: 1300 XXXXXXXXXXXPSKWAAR-------MKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXX 1458
+ R +R + N +VKS++FYW
Sbjct: 520 SEVSGLQIDETWWQMQRRALFKVCYSRRWRRWNRKTRRRCRTMVKSKSFYWLVIVLVFCN 579
Query: 1459 XXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVI 1638
+EHY Q WL Q +AN + LF++EML+KMYSLG Y S FNRFDCFVV
Sbjct: 580 TLSLATEHYRQPPWLTLAQDLANKILLTLFTIEMLVKMYSLGMQQYFVSLFNRFDCFVVC 639
Query: 1639 SSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXX 1818
I+E VL +M+PLG+SVLR RLLRIFK+T W
Sbjct: 640 GGIVELVLTSSKIMEPLGISVLRCVRLLRIFKMTSSWNSLSNLVASLLNSIRSIASLLVL 699
Query: 1819 XXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGI 1998
GMQ+FGG+F+ Q+ K R+NFDTF+QALLTVFQILTGEDWN VMY+GI
Sbjct: 700 LFLFIIIFALLGMQMFGGRFSEIEQEDKIRSNFDTFLQALLTVFQILTGEDWNVVMYNGI 759
Query: 1999 ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSL 2136
E++GG T+G++ +Y+IVLFI GNYILLNVFLAIAVDNLADA+SL
Sbjct: 760 EAYGGASTIGLLTSVYFIVLFIGGNYILLNVFLAIAVDNLADAESL 805
Score = 113 bits (282), Expect = 6e-23
Identities = 93/337 (27%), Positives = 159/337 (46%), Gaps = 13/337 (3%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
N +R C IV + F IL I + IALA P A + +N +LE +YVF VF
Sbjct: 928 NRLRVFCYDIVNYNWFNNAILACIILSSIALACEDPVSAHSA--RNKVLEYFDYVFTGVF 985
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILS--KMSIQGFDVKALRAF 576
+E VLK+ A G H ++ R+ +N+LD ++V + LVS + + K S+ VK LR
Sbjct: 986 AVEIVLKMTAFGVFLHKGSFCRSYFNLLDLLVVAVSLVSMLSNSDKFSV----VKILRVL 1041
Query: 577 -RVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTC 753
VLRPLR ++ L+ V+ + A+ + +I ++ + ++A IG++LF G+L+
Sbjct: 1042 PSVLRPLRAINRAKGLKHVVQCVFVAISTIGNIMVITGLLQFMFACIGVQLFKGRLYY-- 1099
Query: 754 IDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECS-SNTTWPGPNNGITNFD 930
C ++ + +C + + E W N N+D
Sbjct: 1100 ---------------CTDQSKETKEECHGKFFVYSKDGNGEPRVEERLW---ENSEFNYD 1141
Query: 931 NFGLAMLTVFQCVSLEGWTDVMYWVNDA---------VGREWPWIYFVTLVILGSFFVLN 1083
N AMLT+F + EGW ++Y D+ R+ +++ +I+ +FF++N
Sbjct: 1142 NVMNAMLTLFVVATFEGWPGLLYKSIDSWSENHGPRYDARQAVALFYFVFIIVIAFFMMN 1201
Query: 1084 LVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLK 1194
+ +G + F ++ E+ K ++Q LE LK
Sbjct: 1202 IFVGFVIVTFQEQGEQEYKNCELDK-NQRQCLEYALK 1237
Score = 105 bits (262), Expect = 1e-20
Identities = 91/358 (25%), Positives = 155/358 (42%), Gaps = 45/358 (12%)
Frame = +1
Query: 3307 RNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGV 3477
+N ++ V R F+ +I L I+ N V+LA +P S + L+ IF G+
Sbjct: 170 KNPIRKACMKIVDWRPFDVLILLTILANCVALAVYVPFPGDDSNRTNEILEKVEYIFLGI 229
Query: 3478 FAFEAVLKIVA----LNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFR 3645
F EA+LKI+A +P Y+ + WNV D ++VV + I N G T+ + R
Sbjct: 230 FTIEAILKIIAYGLFFHPNAYLRNGWNVIDFVIVVIGLVSIVLETANVGSTD--KVRSLR 287
Query: 3646 LFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKV--- 3813
FRV+R ++L+S + +L +++ L ++ALL++ + IYAV+G++ F GK+
Sbjct: 288 AFRVLRPLRLVSGVPSLEVVLNAIIRAMVPLLHIALLVIFVIIIYAVVGLELFKGKLHKT 347
Query: 3814 ------------------ALDDSTSIHRNN----------------NFHSFPAAILVLFR 3891
A DS H + NF +F A++ +F+
Sbjct: 348 CYHNEVAVLIMEDEAKPCADSDSWGRHCSGGMICESDWAGPSKGIINFDTFYFAVITVFQ 407
Query: 3892 SATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVI 4071
T E W D++ +D GN + + YF+S ++ SF V+
Sbjct: 408 CITMEGWTDVLYYMND---------------------AVGNLWPWIYFVSLIIIGSFFVM 446
Query: 4072 NLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
NL + V+ F + G + +R + D D KG ++D +T + P
Sbjct: 447 NLILGVLSGEFSKEREKANARGEF---QKLREKQQTDEDMKG---YMDWITQAEDLDP 498
Score = 104 bits (260), Expect = 2e-20
Identities = 74/305 (24%), Positives = 147/305 (47%), Gaps = 6/305 (1%)
Frame = +1
Query: 3205 NEGEREYENCELDKN----QRKCIEFALKAKPHRRYIPRNRLQYRVWWFVTSRAFEYVIF 3372
N+ + E ++D+ QR+ + ++ RR+ + R + R V S++F +++
Sbjct: 516 NDADSEVSGLQIDETWWQMQRRALFKVCYSRRWRRWNRKTRRRCRT--MVKSKSFYWLVI 573
Query: 3373 LIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVF 3552
+++ NT+SLA +HY D+ N I +F E ++K+ +L + Y +N F
Sbjct: 574 VLVFCNTLSLATEHYRQPPWLTLAQDLANKILLTLFTIEMLVKMYSLGMQQYFVSLFNRF 633
Query: 3553 DLLVVVGSFIDI--TYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKS 3726
D VV G +++ T K+ + I+ R R++R+ K+ S + L+ + + S
Sbjct: 634 DCFVVCGGIVELVLTSSKI----MEPLGISVLRCVRLLRIFKMTSSWNSLSNLVASLLNS 689
Query: 3727 FQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGE 3906
+++ + +L+ L I+A++GMQ FG + +NF +F A+L +F+ TGE
Sbjct: 690 IRSIASLLVLLFLFIIIFALLGMQMFGGRFSEIEQEDKIRSNFDTFLQALLTVFQILTGE 749
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVA 4086
W +M + + GG + YFI F+ +++++N+F+A
Sbjct: 750 DWNVVMYNGIEA-------------YGGASTI---GLLTSVYFIVLFIGGNYILLNVFLA 793
Query: 4087 VIMDN 4101
+ +DN
Sbjct: 794 IAVDN 798
Score = 103 bits (257), Expect = 5e-20
Identities = 76/283 (26%), Positives = 121/283 (41%), Gaps = 26/283 (9%)
Frame = +1
Query: 2305 VKPIPKAS----SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN 2472
+KP P A +L LS N R C +V+ F +L IL + LA P +
Sbjct: 151 IKPDPNAGRAPQALLCLSLKNPIRKACMKIVDWRPFDVLILLTILANCVALAVYVPFPGD 210
Query: 2473 STR--NMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSF 2646
+ N IL +Y F +FT+E LK+I +GL FH ++ RN +N++D ++V + L S
Sbjct: 211 DSNRTNEILEKVEYIFLGIFTIEAILKIIAYGLFFHPNAYLRNGWNVIDFVIVVIGLVSI 270
Query: 2647 VLRTDAMSXXXXXXXXXXXXXXXAINRAKG---LKHVVQCVIVAVKTIGNIMLVTFMLQF 2817
VL T + + G L+ V+ +I A+ + +I L+ +
Sbjct: 271 VLETANVGSTDKVRSLRAFRVLRPLRLVSGVPSLEVVLNAIIRAMVPLLHIALLVIFVII 330
Query: 2818 MFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVW---------- 2967
++A++G++LFKG K+ + E D KP + W
Sbjct: 331 IYAVVGLELFKG---------KLHKTCYHNEVAVLIMEDEAKPCADSDSWGRHCSGGMIC 381
Query: 2968 -------SNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
S NFD A+I++F T EGW +LY D+
Sbjct: 382 ESDWAGPSKGIINFDTFYFAVITVFQCITMEGWTDVLYYMNDA 424
Score = 102 bits (253), Expect = 1e-19
Identities = 80/322 (24%), Positives = 141/322 (42%), Gaps = 25/322 (7%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP + IV FE+ +L +I N + LA+ Q S +L + YVF +F
Sbjct: 1248 NPWQYKVWFIVNSTYFEYFMLVLILLNTVCLAVQHH---QQSKELTVILNHMNYVFTALF 1304
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKM---SIQGFDVKALRA 573
+E ++K+VA + P YL + WN+ D +IV+ +V + S++ + + F + R
Sbjct: 1305 ALEMIVKLVA----YKPRGYLSDPWNVFDSLIVIGSIVDIVFSELDHGNEKSFSINFFRL 1360
Query: 574 FRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTC 753
FRVLR ++L+S ++ +L +++ L ++ALL++ + IYA+IG+++F GK+
Sbjct: 1361 FRVLRLVKLLSRGEGIRTLLWTFIKSFPALPYVALLIIMLFFIYAVIGMQIF-GKI---- 1415
Query: 754 IDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDN 933
+P+D N NF
Sbjct: 1416 ---------------------------KPNDG-----------------SQINRNNNFQT 1431
Query: 934 FGLAMLTVFQCVSLEGWTDVM-----------------YWVND-----AVGREWPWIYFV 1047
F A+L +F+C + E W +VM Y D G ++ + YF+
Sbjct: 1432 FLQAVLLLFRCATGESWQEVMLACASGNECDDESDWNYYGDKDISAKFTCGNDFAYTYFL 1491
Query: 1048 TLVILGSFFVLNLVLGVLSGEF 1113
T +L +F ++NL + V+ F
Sbjct: 1492 TFYMLCAFLIINLFVAVIMDNF 1513
Score = 76.6 bits (187), Expect = 6e-12
Identities = 57/232 (24%), Positives = 96/232 (40%), Gaps = 19/232 (8%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+H+ QS+ L N F LF++EM++K+ + Y + +N FD +VI SI++
Sbjct: 1281 QHHQQSKELTVILNHMNYVFTALFALEMIVKLVAYKPRGYLSDPWNVFDSLIVIGSIVDI 1340
Query: 1657 VLVYFD--LMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXX 1830
V D K ++ R R+LR+ K+
Sbjct: 1341 VFSELDHGNEKSFSINFFRLFRVLRLVKLLSRGEGIRTLLWTFIKSFPALPYVALLIIML 1400
Query: 1831 XXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVM-------- 1986
GMQ+FG + Q NF TF+QA+L +F+ TGE W VM
Sbjct: 1401 FFIYAVIGMQIFGKIKPNDGSQINRNNNFQTFLQAVLLLFRCATGESWQEVMLACASGNE 1460
Query: 1987 --------YHGIESFGGVGTLG-VIVCIYYIVLFICGNYILLNVFLAIAVDN 2115
Y+G + T G Y++ ++ ++++N+F+A+ +DN
Sbjct: 1461 CDDESDWNYYGDKDISAKFTCGNDFAYTYFLTFYMLCAFLIINLFVAVIMDN 1512
Score = 44.3 bits (103), Expect = 0.035
Identities = 56/254 (22%), Positives = 98/254 (38%), Gaps = 42/254 (16%)
Frame = +1
Query: 1474 SEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVIS 1641
S H +++ L++F + F +F++E++LKM + G ++ S FN D VV
Sbjct: 965 SAHSARNKVLEYFDYV----FTGVFAVEIVLKMTAFGVFLHKGSFCRSYFNLLDLLVVAV 1020
Query: 1642 SILEFVLVY--FDLMKPLGV--SVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXX 1809
S++ + F ++K L V SVLR R + K K+
Sbjct: 1021 SLVSMLSNSDKFSVVKILRVLPSVLRPLRAINRAKGLKH------VVQCVFVAISTIGNI 1074
Query: 1810 XXXXXXXXXXXXXXGMQVFGGKFNFNPQQPK--------------------PRA------ 1911
G+Q+F G+ + Q K PR
Sbjct: 1075 MVITGLLQFMFACIGVQLFKGRLYYCTDQSKETKEECHGKFFVYSKDGNGEPRVEERLWE 1134
Query: 1912 ----NFDTFVQALLTVFQILTGEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFIC 2067
N+D + A+LT+F + T E W ++Y I+S+ G V ++Y V I
Sbjct: 1135 NSEFNYDNVMNAMLTLFVVATFEGWPGLLYKSIDSWSENHGPRYDARQAVALFYFVFIIV 1194
Query: 2068 GNYILLNVFLAIAV 2109
+ ++N+F+ +
Sbjct: 1195 IAFFMMNIFVGFVI 1208
Score = 43.5 bits (101), Expect = 0.059
Identities = 46/244 (18%), Positives = 92/244 (36%), Gaps = 9/244 (3%)
Frame = +1
Query: 2371 CNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQ------ANSTRNMILNYFDYFFTSVFTV 2532
C +V F V+ + ++ LA E Q A N IL ++FT+
Sbjct: 559 CRTMVKSKSFYWLVIVLVFCNTLSLATEHYRQPPWLTLAQDLANKIL-------LTLFTI 611
Query: 2533 EITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXX 2712
E+ +K+ G+ + + FN D VV + VL + +
Sbjct: 612 EMLVKMYSLGMQ----QYFVSLFNRFDCFVVCGGIVELVLTSSKIMEPLGISVLRCVRLL 667
Query: 2713 XAINRAKG---LKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSK 2883
L ++V ++ ++++I +++++ F+ +FA++G+Q+F G F K
Sbjct: 668 RIFKMTSSWNSLSNLVASLLNSIRSIASLLVLLFLFIIIFALLGMQMFGGRFSEIEQEDK 727
Query: 2884 MTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYV 3063
+ NFD A++++F + T E W ++Y
Sbjct: 728 IRS------------------------------NFDTFLQALLTVFQILTGEDWNVVMYN 757
Query: 3064 AIDS 3075
I++
Sbjct: 758 GIEA 761
>gi|691720|gb|AAA62612.1| murine erythroleukemia cardiac calcium
channel
Length = 1869
Score = 986 bits (2548), Expect = 0.0
Identities = 496/819 (60%), Positives = 620/819 (75%), Gaps = 1/819 (0%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPR +SE+ P+P+AS+ FI S N FR+ C+ +VN + FTN +LF IL+SS L
Sbjct: 619 RPRPLSELHLKEKAVPMPEASAFFIFSPNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 678
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP+Q S RN + Y G HKGSFCRN FN+LD+LV+
Sbjct: 679 AAEDPVQHTSFRNHMTAY--------------------GAFLHKGSFCRNYFNILDLLVL 718
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
VSL SF +++ A++ AINRAKGLKHVVQCV VA++TIGNI++VT
Sbjct: 719 CVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 778
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG + C+D SK EAEC+G YI Y+DG+ P+ + R W N+ F+
Sbjct: 779 LLQFMFACIGVQLFKGKLYTCSDSSKQAEAECKGNYITYKDGEVDHPIIQPRSWENSKFD 838
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP+LLY +IDS+ EDKGPI+N R +++
Sbjct: 839 FDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFM 898
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N+ QY+VW+ V
Sbjct: 899 MNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVN 958
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S F+ +++ N++FTG+F E +LK++A PK
Sbjct: 959 STYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKG 1018
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGGTNL-ISINFFRLFRVMRLVKLLSRGEGIRT 3702
Y SD WNVFD L+V+GS ID+ + N N ISI FFRLFRVMRLVKLLSRGEGIRT
Sbjct: 1019 YFSDPWNVFDFLIVIGSIIDVILSETNSAEENSRISITFFRLFRVMRLVKLLSRGEGIRT 1078
Query: 3703 LLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILV 3882
LLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL+D+T I+RNNNF +FP A+L+
Sbjct: 1079 LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLL 1138
Query: 3883 LFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSF 4062
LFR ATGEAWQDIML+C + +C P S+ + E+ CG++FA YFISF+MLC+F
Sbjct: 1139 LFRCATGEAWQDIMLACMPGK--KCAPESEPSNSTE-GETPCGSSFAVFYFISFYMLCAF 1195
Query: 4063 LVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKIS 4242
L+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+W+EYDP AKGRIKHLDVVTLLR+I
Sbjct: 1196 LIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPKAKGRIKHLDVVTLLRRIH 1255
Query: 4243 PPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNIDEANEQL 4422
PPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFALVRT L+I TEGN+++ANE+L
Sbjct: 1256 PPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEEL 1315
Query: 4423 RSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEMEAKGVLP 4602
R+ IK+IWKRT LLD+VVPPAG +D+VTVGKFYATFLIQ+YFR+FK+RKE G P
Sbjct: 1316 RAIIKKIWKRTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQEYFRKFKERKEQGLVG-KP 1373
Query: 4603 AQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDE 4719
+Q A++LQAGLRTLH+IGPE++RAISG+L + D+
Sbjct: 1374 SQR-NALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDK 1411
Score = 516 bits (1329), Expect = e-144
Identities = 280/539 (51%), Positives = 332/539 (60%), Gaps = 41/539 (7%)
Frame = +1
Query: 652 MIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPA--TGQLAQKDPTPCGTDTEGSA 825
M+PLLHIALLVLFVI+IYAIIGLELF GK+H TC + A++DP+PC +T G
Sbjct: 1 MVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIIDVPAKEDPSPCALET-GHG 59
Query: 826 FKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWV 1005
+CQ + ++ G W GP +GITNFDNF AMLTVFQC+++EGWTDV+YWV
Sbjct: 60 RQCQ-NGTVCKPG----------WDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWV 108
Query: 1006 NDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQQLEE 1185
NDAVGR+WPWIYFVTL+I+GSFFVLNLVLGVLSGEFSKEREKA+ARG FQK REKQQLEE
Sbjct: 109 NDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEE 168
Query: 1186 DLKGYLDWITQAEDIEPVNEDEQEDE---------------------------------P 1266
DLKGYLDWITQAEDI+P NEDE DE P
Sbjct: 169 DLKGYLDWITQAEDIDPENEDEGMDEDKPRNRGAPAGLHDQKKGKFAWFSHSTETHVSMP 228
Query: 1267 VAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLE------KLNXXXXXXXXXLVKSQTFY 1428
++T ++ A R+ + + + N VKS FY
Sbjct: 229 TSETESVNTDNVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFY 288
Query: 1429 WXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQ 1608
W SEHY Q WL Q AN + LF+ EMLLKMYSLG Y S
Sbjct: 289 WLVIFLVFLNTLTIASEHYNQPHWLTEDQDTANKALLALFTAEMLLKMYSLGLQAYFVSL 348
Query: 1609 FNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXX 1788
FNRFDCF+V ILE +LV +M PLG+SVLR RLLRIFK+T+YW
Sbjct: 349 FNRFDCFIVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNS 408
Query: 1789 XXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGE 1968
GMQ+FGGKFNF+ Q + R+ FD F Q+LLTVFQILTGE
Sbjct: 409 VRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTR-RSTFDNFPQSLLTVFQILTGE 467
Query: 1969 DWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNA 2145
DWN+VMY GI ++GG G++VCIY+I+LFICGNYILLNVFLAIAVDNLADA+SLT+A
Sbjct: 468 DWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSA 526
Score = 98.6 bits (244), Expect = 2e-18
Identities = 90/342 (26%), Positives = 148/342 (42%), Gaps = 10/342 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V NN R C IV F LILF I + I+L
Sbjct: 619 RPRPLSELHLKEKAVPMPEASAFFIFSPNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 678
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P Q + ++N + A G H ++ RN +NILD +
Sbjct: 679 AAEDP--VQHTSFRNHM--------------------TAYGAFLHKGSFCRNYFNILDLL 716
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
++ + L+S + +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 717 VLCVSLISFGIQSSAINV--VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIV 774
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ-KDPTPCGTDTEGSAFKCQPSDSL 852
++ + ++A IG++LF GKL+ TC D + A+ K D E QP
Sbjct: 775 IVTTLLQFMFACIGVQLFKGKLY-TCSDSSKQAEAECKGNYITYKDGEVDHPIIQPRS-- 831
Query: 853 TNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWP 1032
WE N +FDN AM+ +F + EGW +++Y D+ +
Sbjct: 832 ------WE-----------NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKG 874
Query: 1033 WIY---------FVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
IY F+ +I+ +FF++N+ +G + F ++ E+
Sbjct: 875 PIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 916
Score = 94.7 bits (234), Expect = 2e-17
Identities = 63/259 (24%), Positives = 124/259 (47%), Gaps = 5/259 (1%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S F +++ ++ +NT+++A +HY + D N +F E +LK+ +L
Sbjct: 282 VKSNVFYWLVIFLVFLNTLTIASEHYNQPHWLTEDQDTANKALLALFTAEMLLKMYSLGL 341
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD +V G ++ + + + I+ R R++R+ K+ +
Sbjct: 342 QAYFVSLFNRFDCFIVCGGILETIL--VETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 399
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + + S +++ + LL+ L I++++GMQ F GK D+ + R + F +FP ++
Sbjct: 400 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT--RRSTFDNFPQSL 457
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNF----AYPYFISF 4044
L +F+ TGE W +M D G G +F YFI
Sbjct: 458 LTVFQILTGEDWNSVMY--------------DGIMAYG------GPSFPGMLVCIYFIIL 497
Query: 4045 FMLCSFLVINLFVAVIMDN 4101
F+ +++++N+F+A+ +DN
Sbjct: 498 FICGNYILLNVFLAIAVDN 516
Score = 94.4 bits (233), Expect = 3e-17
Identities = 74/304 (24%), Positives = 131/304 (42%), Gaps = 22/304 (7%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+L+ +I N I LA+ Q Y Q +K + + +F +FT+E +LK++A F
Sbjct: 962 FEYLMFVLILLNTICLAM-QHY-GQSCLFK-IAMNILNMLFTGLFTVEMILKLIA----F 1014
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMSI----QGFDVKALRAFRVLRPLRLVSGVP 615
P Y + WN+ DF+IV+ ++ ILS+ + + R FRV+R ++L+S
Sbjct: 1015 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNSAEENSRISITFFRLFRVMRLVKLLSRGE 1074
Query: 616 SLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPT 795
++ +L +++ L ++ALL++ + IYA+IG+++F G++A D T
Sbjct: 1075 GIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-------------GKIALNDTT 1121
Query: 796 PCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSL 975
N NF F A+L +F+C +
Sbjct: 1122 EI------------------------------------NRNNNFQTFPQAVLLLFRCATG 1145
Query: 976 EGWTDVMYWV------------------NDAVGREWPWIYFVTLVILGSFFVLNLVLGVL 1101
E W D+M G + YF++ +L +F ++NL + V+
Sbjct: 1146 EAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVI 1205
Query: 1102 SGEF 1113
F
Sbjct: 1206 MDNF 1209
Score = 75.1 bits (183), Expect = 2e-11
Identities = 57/229 (24%), Positives = 98/229 (41%), Gaps = 16/229 (6%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HYGQS + N+ F LF++EM+LK+ + Y + +N FD +VI SI++
Sbjct: 980 QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDV 1039
Query: 1657 VLVYFDLMKP---LGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXX 1827
+L + + + ++ R R++R+ K+
Sbjct: 1040 ILSETNSAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVM 1099
Query: 1828 XXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGI--- 1998
GMQVFG + + NF TF QA+L +F+ TGE W +M +
Sbjct: 1100 LFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGK 1159
Query: 1999 ----ESFGGVGTLGVIVC------IYYIVLFICGNYILLNVFLAIAVDN 2115
ES T G C Y+I ++ ++++N+F+A+ +DN
Sbjct: 1160 KCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDN 1208
Score = 68.6 bits (166), Expect = 2e-09
Identities = 78/330 (23%), Positives = 135/330 (40%), Gaps = 10/330 (3%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALA---IYQPY-PAQDSDYKNTLLETIEYV 387
N R+ C + V+ F +L++F++ N + +A QP+ +D D N L
Sbjct: 271 NRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPHWLTEDQDTANKAL------ 324
Query: 388 FIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG-FDVKA 564
+ +FT E +LK+ ++G AY + +N D IV G++ TIL + I +
Sbjct: 325 -LALFTAEMLLKMYSLGLQ----AYFVSLFNRFDCFIVCGGILETILVETKIMSPLGISV 379
Query: 565 LRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLH 744
LR R+LR ++ SL ++ ++L ++ IA L+L + L I L
Sbjct: 380 LRCVRLLRIFKITRYWNSLSNLVASLLNSV---RSIASLLLLLFLFIIIFSL-------- 428
Query: 745 STCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITN 924
G G F + +
Sbjct: 429 ------------------LGMQLFGGKFNFDEMQTRRS---------------------T 449
Query: 925 FDNFGLAMLTVFQCVSLEGWTDVMY-WVNDAVGREWP----WIYFVTLVILGSFFVLNLV 1089
FDNF ++LTVFQ ++ E W VMY + G +P IYF+ L I G++ +LN+
Sbjct: 450 FDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVF 509
Query: 1090 LGVLSGEFSKEREKARARGLFQKFREKQQL 1179
L + + A+ ++ +E+++L
Sbjct: 510 LAIAVDNLADAESLTSAQKEEEEEKERKKL 539
Score = 43.5 bits (101), Expect = 0.059
Identities = 46/209 (22%), Positives = 80/209 (38%), Gaps = 39/209 (18%)
Frame = +1
Query: 3736 LPYVALLIVLLFFIYAVIGMQFF-GKV--------------ALDDSTSI----------- 3837
L ++ALL++ + IYA+IG++ F GK+ A +D +
Sbjct: 4 LLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIIDVPAKEDPSPCALETGHGRQCQ 63
Query: 3838 -------------HRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDY 3978
H NF +F A+L +F+ T E W D++ +D
Sbjct: 64 NGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVND------------- 110
Query: 3979 HKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEF 4158
G ++ + YF++ ++ SF V+NL + V+ F G +
Sbjct: 111 --------AVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDF---QK 159
Query: 4159 VRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
+R + + D KG +LD +T I P
Sbjct: 160 LREKQQLEEDLKG---YLDWITQAEDIDP 185
Score = 38.5 bits (88), Expect = 1.9
Identities = 17/70 (24%), Positives = 37/70 (52%), Gaps = 4/70 (5%)
Frame = +1
Query: 1912 NFDTFVQALLTVFQILTGEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYI 2079
+FD + A++ +F + T E W ++Y I+S G + V + I++I+ I +
Sbjct: 838 DFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFF 897
Query: 2080 LLNVFLAIAV 2109
++N+F+ +
Sbjct: 898 MMNIFVGFVI 907
Score = 37.0 bits (84), Expect = 5.5
Identities = 32/115 (27%), Positives = 50/115 (42%), Gaps = 14/115 (12%)
Frame = +1
Query: 2785 NIMLVTFMLQFMFAIIGVQLFKGTFF--------LCNDLSKMTEAECRGEYIH---YEDG 2931
+I L+ + ++AIIG++LF G + + +K + C E H ++G
Sbjct: 6 HIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIIDVPAKEDPSPCALETGHGRQCQNG 65
Query: 2932 DPTKPVSKKRVWSNNDF---NFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEED 3087
KP W NFDN AM+++F T EGW +LY D+ D
Sbjct: 66 TVCKPG-----WDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRD 115
>gi|4557401|ref|NP_000060.1| calcium channel, voltage-dependent, L
type, alpha 1S subunit; calcium channel, L type, alpha 1
polypeptide, isoform 3 (skeletal muscle, hypokalemic
periodic paralysis) [Homo sapiens]
gi|1082920|pir||A55645 calcium channel, voltage-dependent, protein
alpha-1 chain, skeletal muscle, dihydropyridine-sensitive
- human
gi|563323|gb|AAA51902.1| dihydropyridine-sensitive L-type calcium
channel alpha-1 subunit
Length = 1873
Score = 986 bits (2548), Expect = 0.0
Identities = 512/875 (58%), Positives = 624/875 (70%), Gaps = 28/875 (3%)
Frame = +1
Query: 2260 SARPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSA 2439
S RPR ++E+ PIP+ASS FI S TN RV C+ +VN ++FTN +L IL+SSA
Sbjct: 755 SPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSA 814
Query: 2440 MLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDIL 2619
LAAEDP++A+S RN IL +FD FTSVFTVEI LK+ +G HKGSFCRN FN+LD+L
Sbjct: 815 ALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLL 874
Query: 2620 VVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLV 2799
VVAVSL S L + A+S AINRAKGLKHV +C+ VA+ TIGNI+LV
Sbjct: 875 VVAVSLISMGLESSAISVVKILRVLRVLRPLRAINRAKGLKHVARCMFVAISTIGNIVLV 934
Query: 2800 TFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNND 2979
T +LQFMFA IGVQLFKG FF C DLSKMTE ECRG Y Y+DGDP + + R W ++D
Sbjct: 935 TTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHREWVHSD 994
Query: 2980 FNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXX 3159
F+FDNV AM+SLF VSTFEGWPQLLY AIDSN ED GPI+N+R +A+
Sbjct: 995 FHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIILIAF 1054
Query: 3160 XXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWF 3339
GFVIVTFQ +GE EY+NCELDKNQR+C+++ALKA+P R YIP+N QY+VW+
Sbjct: 1055 FMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQVWYI 1114
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
VTS FEY++F +I++NT+ L +HY S D+ N+ FT +F E +LK++A
Sbjct: 1115 VTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMAFKA 1174
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITY--------------------GKLNPGGTNLISINF 3639
+ Y + WNVFD L+V+GS ID+ G ++P + IS F
Sbjct: 1175 RGYFGNPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARISSAF 1234
Query: 3640 FRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVAL 3819
FRLFRVMRL+KLLSR EG+RTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL
Sbjct: 1235 FRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIAL 1294
Query: 3820 DDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNE 3999
D T I+RNNNF +FP A+L+LFR ATGEAWQ+I+L+CS + CDP SD Y G E
Sbjct: 1295 VDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGK--LCDPESD-YAPG--EE 1349
Query: 4000 SRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEY 4179
CG NFAY YFISF+MLC+FLVINLFVAVIMDNFDYLTRDWSILGPHHL+EF +W+EY
Sbjct: 1350 YTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAEY 1409
Query: 4180 DPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFA 4359
DP+AKGRIKHLDVVTLLR+I PPLGFGK CPHR+ACKRLV MNMPLNSDGTV FNATLFA
Sbjct: 1410 DPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFA 1469
Query: 4360 LVRTNLKIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFL 4539
LVRT LKI TEGN ++ANE+LR+ IK+IWKRT LLD+V+PP G +D+VTVGKFYATFL
Sbjct: 1470 LVRTALKIKTEGNFEQANEELRAIIKKIWKRTSMKLLDQVIPPIG-DDEVTVGKFYATFL 1528
Query: 4540 IQDYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTL-HEIGPELKRAISGNLETDFNFD 4716
IQ++FR+F KR+E E G P + + +QAGLRT+ E PE+ R +SG+L + +
Sbjct: 1529 IQEHFRKFMKRQE-EYYGYRPKK--DIVQIQAGLRTIEEEAAPEICRTVSGDLAAEEELE 1585
Query: 4717 E-------PEPQHRRPHSLFNNLVHRLSGAGSKSP 4800
E RR LF + + L S P
Sbjct: 1586 RAMVEAAMEEGIFRRTGGLFGQVDNFLERTNSLPP 1620
Score = 657 bits (1696), Expect = 0.0
Identities = 343/659 (52%), Positives = 435/659 (65%), Gaps = 18/659 (2%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+RK CISIVEWKPFE +IL I ANC+ALA+Y P P D++ N LE +EY F++VF
Sbjct: 38 NPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVF 97
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSI------------Q 546
+IE +KI+A GF+FH AYLR+ WN+LDF IV +G+ + IL ++++
Sbjct: 98 SIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGA 157
Query: 547 GFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLEL 726
G DVKALRAFRVLRPLRLVSGVPSLQVVLN+I +AM+PL HIALLVLF+++IYAIIGLEL
Sbjct: 158 GLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLEL 217
Query: 727 FCGKLHSTCIDPATGQLA---QKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTW 897
F GK+H TC T +A ++P+PC GS +C + S EC
Sbjct: 218 FKGKMHKTCYFIGTDIVATVENEEPSPCART--GSGRRCTINGS--------ECRGGC-- 265
Query: 898 PGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFV 1077
PGPN+GIT+FDNFG +MLTV+QC+++EGWTDV+YWVNDA+G EWPWIYFVTL++LGSFF+
Sbjct: 266 PGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFI 325
Query: 1078 LNLVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAE--DIEPVNEDE 1251
LNLVLGVLSGEF+KEREKA++RG FQK REKQQL+EDL+GY+ WITQ E D+E E +
Sbjct: 326 LNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLDEDLRGYMSWITQGEVMDVEDFREGK 385
Query: 1252 QE-DEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFY 1428
DE + T +K ++ + N +VKS+ FY
Sbjct: 386 LSLDEGGSDTESLYEIAGL----------NKIIQFIRHWRQWNRIFRWKCHDIVKSKVFY 435
Query: 1429 WXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQ 1608
W SEH+ Q WL Q +AN + LF+ EML+KMY LG Y S
Sbjct: 436 WLVILIVALNTLSIASEHHNQPHWLTRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSI 495
Query: 1609 FNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXX 1788
FNRFDCFVV S ILE +LV M PLG+SVLR RLLRIFK+TKYWT
Sbjct: 496 FNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNS 555
Query: 1789 XXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGE 1968
GMQ+FGG+++F + + R+NFD F QAL++VFQ+LTGE
Sbjct: 556 IRSIASLLLLLFLFIVIFRLLGMQLFGGRYDFEDTEVR-RSNFDNFPQALISVFQVLTGE 614
Query: 1969 DWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNA 2145
DW ++MY+GI + G G++VCIY+I+LF+CGNYILLNVFLAIAVDNLA+A+SLT+A
Sbjct: 615 DWTSMMYNGIMASSGPSYPGMLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTSA 673
Score = 162 bits (409), Expect = 1e-37
Identities = 149/685 (21%), Positives = 279/685 (39%), Gaps = 87/685 (12%)
Frame = +1
Query: 2308 KPIPKA-----SSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQA- 2469
KP+P+ +LF L+ N R C +V F +L I + LA P+
Sbjct: 18 KPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPED 77
Query: 2470 -NSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSF 2646
N++ N+ L +YFF VF++E +K+I +G +FH+ ++ R+ +N+LD +V + + +
Sbjct: 78 DNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTV 137
Query: 2647 VLR--------TDAMSXXXXXXXXXXXXXXXAINRAK------GLKHVVQCVIVAVKTIG 2784
+L T MS + + L+ V+ + A+ +
Sbjct: 138 ILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLF 197
Query: 2785 NIMLVTFMLQFMFAIIGVQLFKGT-----FFLCNDLSKMTEAECRGEYIHYEDGDPTKPV 2949
+I L+ + ++AIIG++LFKG +F+ D+ E E E +
Sbjct: 198 HIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENE--------EPSPCARTG 249
Query: 2950 SKKRVWSNND-------------FNFDNVGDAMISLFVVSTFEG---------------W 3045
S +R N +FDN G +M++++ T EG W
Sbjct: 250 SGRRCTINGSECRGGCPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEW 309
Query: 3046 PQLLYVAID-------------------SNEEDKGPIHNSRQAVALXXXXXXXXXXXXXX 3168
P + +V + + E +K + Q +
Sbjct: 310 PWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLDEDLRGYMSW 369
Query: 3169 XXXXGFVIVTFQNEGEREYENCELDKNQ-------RKCIEFALKAKPHRRYIPRNRL-QY 3324
+ V EG+ + D K I+F R + NR+ ++
Sbjct: 370 ITQGEVMDVEDFREGKLSLDEGGSDTESLYEIAGLNKIIQFI------RHWRQWNRIFRW 423
Query: 3325 RVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKI 3504
+ V S+ F +++ LI+ +NT+S+A +H+ D+ N + +F E ++K+
Sbjct: 424 KCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPHWLTRLQDIANRVLLSLFTTEMLMKM 483
Query: 3505 VALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSR 3684
L + Y +N FD VV ++I + G + I+ R R++R+ K+
Sbjct: 484 YGLGLRQYFMSIFNRFDCFVVCSGILEILL--VESGAMTPLGISVLRCIRLLRIFKITKY 541
Query: 3685 GEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSF 3864
+ L+ + + S +++ + LL+ L I+ ++GMQ FG + T + R +NF +F
Sbjct: 542 WTSLSNLVASLLNSIRSIASLLLLLFLFIVIFRLLGMQLFGGRYDFEDTEV-RRSNFDNF 600
Query: 3865 PAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP----- 4029
P A++ +F+ TGE W +M N + +YP
Sbjct: 601 PQALISVFQVLTGEDWTSMM----------------------YNGIMASSGPSYPGMLVC 638
Query: 4030 -YFISFFMLCSFLVINLFVAVIMDN 4101
YFI F+ +++++N+F+A+ +DN
Sbjct: 639 IYFIILFVCGNYILLNVFLAIAVDN 663
Score = 113 bits (283), Expect = 5e-23
Identities = 97/340 (28%), Positives = 157/340 (45%), Gaps = 9/340 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V N IR LC IV F IL I + AL
Sbjct: 757 RPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAAL 816
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P A +N +L+ + F VFT+E VLK+ G H ++ RN +N+LD +
Sbjct: 817 AAEDPIRADSM--RNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLL 874
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S L +I VK LR RVLRPLR ++ L+ V + A+ + +I
Sbjct: 875 VVAVSLISMGLESSAIS--VVKILRVLRVLRPLRAINRAKGLKHVARCMFVAISTIGNIV 932
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLT 855
L+ + ++A IG++LF GK C D L++ C G + + D +
Sbjct: 933 LVTTLLQFMFACIGVQLFKGKFF-RCTD-----LSKMTEEEC----RGYYYVYKDGDPM- 981
Query: 856 NMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDA----VG- 1020
+ +R + W + +FDN AM+++F + EGW ++Y D+ VG
Sbjct: 982 QIELR-----HREWV---HSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGP 1033
Query: 1021 ----REWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKERE 1128
R I+F+ +IL +FF++N+ +G + F ++ E
Sbjct: 1034 IYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGE 1073
Score = 90.5 bits (223), Expect = 4e-16
Identities = 80/336 (23%), Positives = 140/336 (40%), Gaps = 39/336 (11%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP + IV FE+L+ +I N I L + Q Y S+ N + + + F ++F
Sbjct: 1105 NPYQYQVWYIVTSSYFEYLMFALIMLNTICLGM-QHY--NQSEQMNHISDILNVAFTIIF 1161
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKM-----SIQGF----- 552
T+E +LK++A F Y N WN+ DF+IV+ ++ ILS++ S G
Sbjct: 1162 TLEMILKLMA----FKARGYFGNPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGG 1217
Query: 553 -------DVKA------LRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFV 693
D A R FRV+R ++L+S ++ +L +++ L ++ALL++ +
Sbjct: 1218 GCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVML 1277
Query: 694 ILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRW 873
IYA+IG+++F G++A D T
Sbjct: 1278 FFIYAVIGMQMF-------------GKIALVDGTQI------------------------ 1300
Query: 874 ECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVN--------------- 1008
N NF F A+L +F+C + E W +++ +
Sbjct: 1301 ------------NRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGE 1348
Query: 1009 -DAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
G + + YF++ +L +F V+NL + V+ F
Sbjct: 1349 EYTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNF 1384
Score = 75.1 bits (183), Expect = 2e-11
Identities = 58/247 (23%), Positives = 99/247 (39%), Gaps = 34/247 (13%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HY QSE ++H + N+ F I+F++EM+LK+ + Y + +N FD +VI SI++
Sbjct: 1138 QHYNQSEQMNHISDILNVAFTIIFTLEMILKLMAFKARGYFGNPWNVFDFLIVIGSIIDV 1197
Query: 1657 VLVYFDLM----------------------KPLGVSVLRSARLLRIFKVTKYWTXXXXXX 1770
+L D + + R R++R+ K+
Sbjct: 1198 ILSEIDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLL 1257
Query: 1771 XXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVF 1950
GMQ+FG + Q NF TF QA+L +F
Sbjct: 1258 WTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLF 1317
Query: 1951 QILTGEDWNTVMY----------HGIESFGGVGTLGVIVCIYYIVLF--ICGNYILLNVF 2094
+ TGE W ++ + G T G YY + F +C ++++N+F
Sbjct: 1318 RCATGEAWQEILLACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCA-FLVINLF 1376
Query: 2095 LAIAVDN 2115
+A+ +DN
Sbjct: 1377 VAVIMDN 1383
Score = 73.6 bits (179), Expect = 5e-11
Identities = 68/309 (22%), Positives = 127/309 (41%), Gaps = 57/309 (18%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDV----FNLIFTGVFAFEAVLKIVA-- 3510
+ FE +I L I N V+LA + P + L++ F VF+ EA +KI+A
Sbjct: 51 KPFETIILLTIFANCVALAV-YLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYG 109
Query: 3511 --LNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNL---------ISINFFRLFRV 3657
+ Y+ WNV D +V + ++N ++ + + R FRV
Sbjct: 110 FLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRV 169
Query: 3658 MRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GK-------V 3813
+R ++L+S ++ +L + K+ L ++ALL++ + IYA+IG++ F GK +
Sbjct: 170 LRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFI 229
Query: 3814 ALDDSTSI--------------------------------HRNNNFHSFPAAILVLFRSA 3897
D ++ H +F +F ++L +++
Sbjct: 230 GTDIVATVENEEPSPCARTGSGRRCTINGSECRGGCPGPNHGITHFDNFGFSMLTVYQCI 289
Query: 3898 TGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINL 4077
T E W D++ +D GN + + YF++ +L SF ++NL
Sbjct: 290 TMEGWTDVLYWVNDA---------------------IGNEWPWIYFVTLILLGSFFILNL 328
Query: 4078 FVAVIMDNF 4104
+ V+ F
Sbjct: 329 VLGVLSGEF 337
Score = 43.1 bits (100), Expect = 0.077
Identities = 49/245 (20%), Positives = 95/245 (38%), Gaps = 38/245 (15%)
Frame = +1
Query: 1489 QSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEF 1656
+++ L HF ++ F +F++E++LKM + G ++ + FN D VV S++
Sbjct: 828 RNQILKHF----DIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISM 883
Query: 1657 VLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1836
L + V +LR R+LR +
Sbjct: 884 GLESSAISV---VKILRVLRVLRPLRAINRAKGLKHVARCMFVAISTIGNIVLVTTLLQF 940
Query: 1837 XXXXXGMQVFGGKF----------------------NFNPQQPKPRA--------NFDTF 1926
G+Q+F GKF + +P Q + R +FD
Sbjct: 941 MFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHREWVHSDFHFDNV 1000
Query: 1927 VQALLTVFQILTGEDWNTVMYHGIES----FGGVGTLGVIVCIYYIVLFICGNYILLNVF 2094
+ A++++F + T E W ++Y I+S G + V + I++I+ I + ++N+F
Sbjct: 1001 LSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIF 1060
Query: 2095 LAIAV 2109
+ +
Sbjct: 1061 VGFVI 1065
>gi|6165995|sp|Q13698|CCAS_HUMAN Voltage-dependent L-type calcium
channel alpha-1S subunit (Voltage-gated calcium channel
alpha subunit Cav1.1) (Calcium channel, L type, alpha-1
polypeptide, isoform 3, skeletal muscle)
Length = 1873
Score = 985 bits (2547), Expect = 0.0
Identities = 514/875 (58%), Positives = 623/875 (70%), Gaps = 28/875 (3%)
Frame = +1
Query: 2260 SARPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSA 2439
S RPR ++E+ PIP+ASS FI S TN RV C+ +VN ++FTN +L IL+SSA
Sbjct: 755 SPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSA 814
Query: 2440 MLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDIL 2619
LAAEDP++A+S RN IL +FD FTSVFTVEI LK+ +G HKGSFCRN FN+LD+L
Sbjct: 815 ALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLL 874
Query: 2620 VVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLV 2799
VVAVSL S L + A+S AINRAKGLKHVVQC+ VA+ TIGNI+LV
Sbjct: 875 VVAVSLISMGLESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNIVLV 934
Query: 2800 TFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNND 2979
T +LQFMFA IGVQLFKG FF C DLSKMTE ECRG Y Y+DGDP + + R W ++D
Sbjct: 935 TTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHREWVHSD 994
Query: 2980 FNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXX 3159
F+FDNV AM+SLF VSTFEGWPQLLY AIDSN ED GPI+N+R +A+
Sbjct: 995 FHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIILIAF 1054
Query: 3160 XXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWF 3339
GFVIVTFQ +GE EY+NCELDKNQR+C+++ALKA+P R YIP+N QY+VW+
Sbjct: 1055 FMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQVWYI 1114
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
VTS FEY++F +I++NT+ L +HY S D+ N+ FT +F E +LK++A
Sbjct: 1115 VTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMAFKA 1174
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITY--------------------GKLNPGGTNLISINF 3639
+ Y D WNVFD L+V+GS ID+ G ++P + IS F
Sbjct: 1175 RGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARISSAF 1234
Query: 3640 FRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVAL 3819
FRLFRVMRL+KLLSR EG+RTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL
Sbjct: 1235 FRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIAL 1294
Query: 3820 DDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNE 3999
D T I+RNNNF +FP A+L+LFR ATGEAWQ+I+L+CS + CDP SD Y G E
Sbjct: 1295 VDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGK--LCDPESD-YAPG--EE 1349
Query: 4000 SRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEY 4179
CG NFAY YFISF+MLC+FLVINLFVAVIMDNFDYLTRDWSILGPHHL+EF +W+EY
Sbjct: 1350 YTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAEY 1409
Query: 4180 DPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFA 4359
DP+AKGRIKHLDVVTLLR+I PPLGFGK CPHR+ACKRLV MNMPLNSDGTV FNATLFA
Sbjct: 1410 DPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFA 1469
Query: 4360 LVRTNLKIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFL 4539
LV T LKI TEGN ++ANE+LR+ IK+IWKRT LLD+V+PP G +D+VTVGKFYATFL
Sbjct: 1470 LVGTALKIKTEGNFEQANEELRAIIKKIWKRTSMKLLDQVMPPIG-DDEVTVGKFYATFL 1528
Query: 4540 IQDYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTL-HEIGPELKRAISGNLETDFNFD 4716
IQ+ FR+F KR+E E G P + + +QAGLRT+ E PE+ R +SG+L + +
Sbjct: 1529 IQEDFRKFMKRQE-EYYGYRPKK--DIVQIQAGLRTIEEEAAPEICRTVSGDLAAEEELE 1585
Query: 4717 E-------PEPQHRRPHSLFNNLVHRLSGAGSKSP 4800
E RR LF + + L S P
Sbjct: 1586 RAMVEAAMEEGIFRRTGGLFGQVDNFLERTNSLPP 1620
Score = 665 bits (1717), Expect = 0.0
Identities = 345/659 (52%), Positives = 438/659 (66%), Gaps = 18/659 (2%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+RK CISIVEWKPFE +IL I ANC+ALA+Y P P D++ N LE +EY F++VF
Sbjct: 38 NPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVF 97
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSI------------Q 546
+IE +KI+A GF+FH AYLR+ WN+LDF IV +G+ + IL ++++
Sbjct: 98 SIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGA 157
Query: 547 GFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLEL 726
G DVKALRAFRVLRPLRLVSGVPSLQVVLN+I +AM+PL HIALLVLF+++IYAIIGLEL
Sbjct: 158 GLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLEL 217
Query: 727 FCGKLHSTCIDPATGQLA---QKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTW 897
F GK+H TC T +A ++P+PC GS +C + S EC W
Sbjct: 218 FKGKMHKTCYFIGTDIVATVENEEPSPCART--GSGRRCTINGS--------ECRGG--W 265
Query: 898 PGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFV 1077
PGPN+GIT+FDNFG +MLTV+QC+++EGWTDV+YWVNDA+G EWPWIYFVTL++LGSFF+
Sbjct: 266 PGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFI 325
Query: 1078 LNLVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAE--DIEPVNEDE 1251
LNLVLGVLSGEF+KEREKA++RG FQK REKQQL+EDL+GY+ WITQ E D+E E +
Sbjct: 326 LNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLDEDLRGYMSWITQGEVMDVEDFREGK 385
Query: 1252 QE-DEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFY 1428
DE + T +K ++ + N +VKS+ FY
Sbjct: 386 LSLDEGGSDTESLYEIAGL----------NKIIQFIRHWRQWNRIFRWKCHDIVKSKVFY 435
Query: 1429 WXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQ 1608
W SEH+ Q WL Q +AN + LF+ EML+KMY LG Y S
Sbjct: 436 WLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSI 495
Query: 1609 FNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXX 1788
FNRFDCFVV S ILE +LV M PLG+SVLR RLLRIFK+TKYWT
Sbjct: 496 FNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNS 555
Query: 1789 XXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGE 1968
GMQ+FGG+++F + + R+NFD F QAL++VFQ+LTGE
Sbjct: 556 IRSIASLLLLLFLFIVIFALLGMQLFGGRYDFEDTEVR-RSNFDNFPQALISVFQVLTGE 614
Query: 1969 DWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNA 2145
DW ++MY+GI ++GG G++VCIY+I+LF+CGNYILLNVFLAIAVDNLA+A+SLT+A
Sbjct: 615 DWTSMMYNGIMAYGGPSYPGMLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTSA 673
Score = 161 bits (408), Expect = 1e-37
Identities = 150/685 (21%), Positives = 279/685 (39%), Gaps = 87/685 (12%)
Frame = +1
Query: 2308 KPIPKA-----SSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQA- 2469
KP+P+ +LF L+ N R C +V F +L I + LA P+
Sbjct: 18 KPVPEILPSPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPED 77
Query: 2470 -NSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSF 2646
N++ N+ L +YFF VF++E +K+I +G +FH+ ++ R+ +N+LD +V + + +
Sbjct: 78 DNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTV 137
Query: 2647 VLR--------TDAMSXXXXXXXXXXXXXXXAINRAK------GLKHVVQCVIVAVKTIG 2784
+L T MS + + L+ V+ + A+ +
Sbjct: 138 ILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLF 197
Query: 2785 NIMLVTFMLQFMFAIIGVQLFKGT-----FFLCNDLSKMTEAECRGEYIHYEDGDPTKPV 2949
+I L+ + ++AIIG++LFKG +F+ D+ E E E +
Sbjct: 198 HIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENE--------EPSPCARTG 249
Query: 2950 SKKRVWSNND-------------FNFDNVGDAMISLFVVSTFEG---------------W 3045
S +R N +FDN G +M++++ T EG W
Sbjct: 250 SGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEW 309
Query: 3046 PQLLYVAID-------------------SNEEDKGPIHNSRQAVALXXXXXXXXXXXXXX 3168
P + +V + + E +K + Q +
Sbjct: 310 PWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLDEDLRGYMSW 369
Query: 3169 XXXXGFVIVTFQNEGEREYENCELDKNQ-------RKCIEFALKAKPHRRYIPRNRL-QY 3324
+ V EG+ + D K I+F R + NR+ ++
Sbjct: 370 ITQGEVMDVEDFREGKLSLDEGGSDTESLYEIAGLNKIIQFI------RHWRQWNRIFRW 423
Query: 3325 RVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKI 3504
+ V S+ F +++ LI+ +NT+S+A +H+ D+ N + +F E ++K+
Sbjct: 424 KCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTTEMLMKM 483
Query: 3505 VALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSR 3684
L + Y +N FD VV ++I + G + I+ R R++R+ K+
Sbjct: 484 YGLGLRQYFMSIFNRFDCFVVCSGILEILL--VESGAMTPLGISVLRCIRLLRIFKITKY 541
Query: 3685 GEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSF 3864
+ L+ + + S +++ + LL+ L I+A++GMQ FG + T + R +NF +F
Sbjct: 542 WTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRYDFEDTEV-RRSNFDNF 600
Query: 3865 PAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP----- 4029
P A++ +F+ TGE W +M N +YP
Sbjct: 601 PQALISVFQVLTGEDWTSMM----------------------YNGIMAYGGPSYPGMLVC 638
Query: 4030 -YFISFFMLCSFLVINLFVAVIMDN 4101
YFI F+ +++++N+F+A+ +DN
Sbjct: 639 IYFIILFVCGNYILLNVFLAIAVDN 663
Score = 114 bits (285), Expect = 3e-23
Identities = 97/340 (28%), Positives = 158/340 (45%), Gaps = 9/340 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V N IR LC IV F IL I + AL
Sbjct: 757 RPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAAL 816
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P A +N +L+ + F VFT+E VLK+ G H ++ RN +N+LD +
Sbjct: 817 AAEDPIRADSM--RNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLL 874
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S L +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 875 VVAVSLISMGLESSAIS--VVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNIV 932
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLT 855
L+ + ++A IG++LF GK C D L++ C G + + D +
Sbjct: 933 LVTTLLQFMFACIGVQLFKGKFF-RCTD-----LSKMTEEEC----RGYYYVYKDGDPM- 981
Query: 856 NMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDA----VG- 1020
+ +R + W + +FDN AM+++F + EGW ++Y D+ VG
Sbjct: 982 QIELR-----HREWV---HSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGP 1033
Query: 1021 ----REWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKERE 1128
R I+F+ +IL +FF++N+ +G + F ++ E
Sbjct: 1034 IYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGE 1073
Score = 88.6 bits (218), Expect = 2e-15
Identities = 79/336 (23%), Positives = 140/336 (41%), Gaps = 39/336 (11%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP + IV FE+L+ +I N I L + Q Y S+ N + + + F ++F
Sbjct: 1105 NPYQYQVWYIVTSSYFEYLMFALIMLNTICLGM-QHY--NQSEQMNHISDILNVAFTIIF 1161
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKM-----SIQGF----- 552
T+E +LK++A F Y + WN+ DF+IV+ ++ ILS++ S G
Sbjct: 1162 TLEMILKLMA----FKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGG 1217
Query: 553 -------DVKA------LRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFV 693
D A R FRV+R ++L+S ++ +L +++ L ++ALL++ +
Sbjct: 1218 GCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVML 1277
Query: 694 ILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRW 873
IYA+IG+++F G++A D T
Sbjct: 1278 FFIYAVIGMQMF-------------GKIALVDGTQI------------------------ 1300
Query: 874 ECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVN--------------- 1008
N NF F A+L +F+C + E W +++ +
Sbjct: 1301 ------------NRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGE 1348
Query: 1009 -DAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
G + + YF++ +L +F V+NL + V+ F
Sbjct: 1349 EYTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNF 1384
Score = 74.7 bits (182), Expect = 2e-11
Identities = 58/247 (23%), Positives = 98/247 (39%), Gaps = 34/247 (13%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HY QSE ++H + N+ F I+F++EM+LK+ + Y +N FD +VI SI++
Sbjct: 1138 QHYNQSEQMNHISDILNVAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFLIVIGSIIDV 1197
Query: 1657 VLVYFDLM----------------------KPLGVSVLRSARLLRIFKVTKYWTXXXXXX 1770
+L D + + R R++R+ K+
Sbjct: 1198 ILSEIDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLL 1257
Query: 1771 XXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVF 1950
GMQ+FG + Q NF TF QA+L +F
Sbjct: 1258 WTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLF 1317
Query: 1951 QILTGEDWNTVMY----------HGIESFGGVGTLGVIVCIYYIVLF--ICGNYILLNVF 2094
+ TGE W ++ + G T G YY + F +C ++++N+F
Sbjct: 1318 RCATGEAWQEILLACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCA-FLVINLF 1376
Query: 2095 LAIAVDN 2115
+A+ +DN
Sbjct: 1377 VAVIMDN 1383
Score = 73.6 bits (179), Expect = 5e-11
Identities = 68/309 (22%), Positives = 127/309 (41%), Gaps = 57/309 (18%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDV----FNLIFTGVFAFEAVLKIVA-- 3510
+ FE +I L I N V+LA + P + L++ F VF+ EA +KI+A
Sbjct: 51 KPFETIILLTIFANCVALAV-YLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYG 109
Query: 3511 --LNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNL---------ISINFFRLFRV 3657
+ Y+ WNV D +V + ++N ++ + + R FRV
Sbjct: 110 FLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRV 169
Query: 3658 MRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GK-------V 3813
+R ++L+S ++ +L + K+ L ++ALL++ + IYA+IG++ F GK +
Sbjct: 170 LRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFI 229
Query: 3814 ALDDSTSI--------------------------------HRNNNFHSFPAAILVLFRSA 3897
D ++ H +F +F ++L +++
Sbjct: 230 GTDIVATVENEEPSPCARTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCI 289
Query: 3898 TGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINL 4077
T E W D++ +D GN + + YF++ +L SF ++NL
Sbjct: 290 TMEGWTDVLYWVNDA---------------------IGNEWPWIYFVTLILLGSFFILNL 328
Query: 4078 FVAVIMDNF 4104
+ V+ F
Sbjct: 329 VLGVLSGEF 337
Score = 42.7 bits (99), Expect = 0.10
Identities = 49/245 (20%), Positives = 95/245 (38%), Gaps = 38/245 (15%)
Frame = +1
Query: 1489 QSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEF 1656
+++ L HF ++ F +F++E++LKM + G ++ + FN D VV S++
Sbjct: 828 RNQILKHF----DIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISM 883
Query: 1657 VLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1836
L + V +LR R+LR +
Sbjct: 884 GLESSAISV---VKILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQF 940
Query: 1837 XXXXXGMQVFGGKF----------------------NFNPQQPKPRA--------NFDTF 1926
G+Q+F GKF + +P Q + R +FD
Sbjct: 941 MFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHREWVHSDFHFDNV 1000
Query: 1927 VQALLTVFQILTGEDWNTVMYHGIES----FGGVGTLGVIVCIYYIVLFICGNYILLNVF 2094
+ A++++F + T E W ++Y I+S G + V + I++I+ I + ++N+F
Sbjct: 1001 LSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIF 1060
Query: 2095 LAIAV 2109
+ +
Sbjct: 1061 VGFVI 1065
>gi|48094843|ref|XP_394283.1| similar to calcium channel,
voltage-dependent, alpha 1F subunit; Cav1.4alpha1 [Apis
mellifera]
Length = 1956
Score = 980 bits (2534), Expect = 0.0
Identities = 503/798 (63%), Positives = 597/798 (74%), Gaps = 19/798 (2%)
Frame = +1
Query: 2716 AINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEA 2895
AINRAKGLKHVVQCVIVAVKTIGNI+LVT +LQF+FA++GVQLFKG FF C D SKMT+
Sbjct: 839 AINRAKGLKHVVQCVIVAVKTIGNIVLVTSLLQFVFAVVGVQLFKGKFFYCTDASKMTKE 898
Query: 2896 ECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
EC+G Y+ +E+G+ KP+ K+R W F+FD+V AM++LF VSTFEGWP LL +IDS
Sbjct: 899 ECQGTYLEFENGNINKPIMKERNWCQQRFHFDDVAKAMLTLFTVSTFEGWPSLLDYSIDS 958
Query: 3076 NEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIVTFQNEGEREYENCELDKNQR 3255
N+ED GPIHN R VA GFVIVTFQNEGE+EY+NCELDKNQR
Sbjct: 959 NKEDHGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNEGEQEYKNCELDKNQR 1018
Query: 3256 KCIEFALKAKPHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGF 3435
CIEFALKAKP RRYIP++R+QY+VWWFVTS+ FEY IF +I++NTV+LA K Y +
Sbjct: 1019 NCIEFALKAKPVRRYIPKHRIQYKVWWFVTSQPFEYTIFTLIMINTVTLAMKFYRQPEIY 1078
Query: 3436 EDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGG 3615
LDV N+IFT VFA E + K+ A KNY D WNVFD ++V+GSFIDI Y ++NPG
Sbjct: 1079 TQALDVLNMIFTAVFALEFIFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEVNPGS 1138
Query: 3616 TNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGM 3795
T +ISINFFRLFRVMRLVKLLSRGEGIRTLLWTF+KSFQALPYVALLI++LFFIYAVIGM
Sbjct: 1139 T-IISINFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIIMLFFIYAVIGM 1197
Query: 3796 QFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDRED-VRCDPMSD 3972
Q FGK+A+DD TSI+RNNNF SFP A+LVLFRSATGE+WQ+IM+ CS + V+CDP SD
Sbjct: 1198 QVFGKIAIDDETSINRNNNFQSFPQAVLVLFRSATGESWQEIMMDCSVQPGKVKCDPNSD 1257
Query: 3973 DYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLE 4152
+ LN + CG++ A+PYFISF++LCSFL+INLFVAVIMDNFDYLTRDWSILGPHHL+
Sbjct: 1258 E----ALNTNGCGSDIAFPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLD 1313
Query: 4153 EFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGT 4332
EF+RLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHR+ACKRLVSMNMPLNSDGT
Sbjct: 1314 EFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRVACKRLVSMNMPLNSDGT 1373
Query: 4333 VCFNATLFALVRTNLKIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVT 4512
V FNATLFA+VRT+L+I TEGNID+AN +LR+ IK+IWKRT LLD+VVPP G +D+VT
Sbjct: 1374 VLFNATLFAVVRTSLRIKTEGNIDDANAELRAVIKKIWKRTSPKLLDQVVPPPGGDDEVT 1433
Query: 4513 VGKFYATFLIQDYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGN 4692
VGKFYATFLIQDYFRRFKKRKE E K + + LQAGLRTLHE GPELKRAISGN
Sbjct: 1434 VGKFYATFLIQDYFRRFKKRKEQEMKDG-DKECHNTVTLQAGLRTLHEAGPELKRAISGN 1492
Query: 4693 LETDFNFDEPEPQHRRPHSLFNNLVHRL-SGAGSKSPTEHERIEKGSTLLPFQPRSFSPT 4869
LE + D PEP HRR HSLF ++ + G S + ++ S P F P
Sbjct: 1493 LE-ELLDDNPEPMHRRNHSLFGSVWSSMRKGHHSFNRARSLKVNSTSKASPTNSIDFVPY 1551
Query: 4870 HSLAGAEGSP---VPSQMHRGAP----------INQSINLPPVNGSARRLPALP--PYAN 5004
S G P + ++ H+ P +NQ P + G +P P + N
Sbjct: 1552 SSFHRGGGDPSNQITARSHQVVPNVAGGLSDSAMNQMGIDPKLTGIEESIPLRPLAVFGN 1611
Query: 5005 HIHDETDDGPRYR--DTG 5052
+ ++ Y+ DTG
Sbjct: 1612 PVQQQSYHHTSYKVLDTG 1629
Score = 681 bits (1756), Expect = 0.0
Identities = 356/640 (55%), Positives = 420/640 (65%), Gaps = 1/640 (0%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+RK+CI +VEWKPFE+LIL I ANCIALA+Y PYP DS+ N LE IEY+F+V+F
Sbjct: 86 NPLRKMCIDVVEWKPFEWLILMTIFANCIALAVYTPYPYGDSNLTNQYLEKIEYIFLVIF 145
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
T+ECV+KI+A GF+ HP AYLRN WNILDF IVVIG+VST+LS + +GFDVKALRAFRV
Sbjct: 146 TVECVMKIIAYGFVAHPGAYLRNGWNILDFSIVVIGMVSTVLSVLMKEGFDVKALRAFRV 205
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLRLVSGVPSLQVVLN+ILRAMIPLLHIALLVLFVI+IYAIIGLELF GK+H TC
Sbjct: 206 LRPLRLVSGVPSLQVVLNSILRAMIPLLHIALLVLFVIIIYAIIGLELFSGKMHKTCRHN 265
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
T + DP PCG ++C N+G + CS W GPN GITNFDNFGL
Sbjct: 266 MTDAI-MDDPVPCGP----GGYQCD------NVGSDYYCSKQ-FWEGPNWGITNFDNFGL 313
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKE 1122
AMLTVFQCV+LEGWT+V+Y + DA+G W WIYF+++VILG+FFV+NL+LGVLSGEFSKE
Sbjct: 314 AMLTVFQCVTLEGWTEVLYNIEDAMGSSWQWIYFISMVILGAFFVMNLILGVLSGEFSKE 373
Query: 1123 REKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEP-VNEDEQEDEPVAQTXXXXXXX 1299
REKA+ARG F K REKQQ+E+DL+GYLDWITQAEDIEP +E + +D Q
Sbjct: 374 REKAKARGDFHKLREKQQIEDDLRGYLDWITQAEDIEPETDEPKMQDGKTKQQSEMESTD 433
Query: 1300 XXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSE 1479
S W + +++N VKSQ FYW +E
Sbjct: 434 QLEGDEEGVQQESLWRRKKLDFDRVNRRMRRACRKAVKSQVFYWLIIVLVFLNTGVLATE 493
Query: 1480 HYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFV 1659
HY Q WLD FQ + N+FF+ LF+MEM+LKMYSLGF Y S FNRFDCFVVI SI E +
Sbjct: 494 HYNQPHWLDDFQEITNMFFIALFTMEMMLKMYSLGFQGYFVSLFNRFDCFVVIGSITEMI 553
Query: 1660 LVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1839
L +M PLGVSVLR RLLR+FKVTKYW
Sbjct: 554 LTNTHVMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVI 613
Query: 1840 XXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVG 2019
GM QILTGEDWN VMY GI ++GGV
Sbjct: 614 FALLGM-------------------------------QILTGEDWNAVMYDGIRAYGGVS 642
Query: 2020 TLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLT 2139
+ G++ C Y+I+LFIC ILLNVFLAIAVDNLADA+SLT
Sbjct: 643 SFGMLACFYFIILFICD--ILLNVFLAIAVDNLADAESLT 680
Score = 93.2 bits (230), Expect = 6e-17
Identities = 74/259 (28%), Positives = 115/259 (43%), Gaps = 15/259 (5%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR--NMILNYF 2502
+LF L N R C VV F +L I + LA P + N L
Sbjct: 78 TLFCLPLKNPLRKMCIDVVEWKPFEWLILMTIFANCIALAVYTPYPYGDSNLTNQYLEKI 137
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXX 2682
+Y F +FTVE +K+I +G V H G++ RN +N+LD +V + + S VL M
Sbjct: 138 EYIFLVIFTVECVMKIIAYGFVAHPGAYLRNGWNILDFSIVVIGMVSTVLSV-LMKEGFD 196
Query: 2683 XXXXXXXXXXXAINRAKG---LKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKG 2853
+ G L+ V+ ++ A+ + +I L+ + ++AIIG++LF G
Sbjct: 197 VKALRAFRVLRPLRLVSGVPSLQVVLNSILRAMIPLLHIALLVLFVIIIYAIIGLELFSG 256
Query: 2854 TFF-LCNDLSKMTEA------ECRGEYIHYEDGDPTKPVSKKRVWSNNDF---NFDNVGD 3003
C MT+A C G + D + K+ W ++ NFDN G
Sbjct: 257 KMHKTCR--HNMTDAIMDDPVPC-GPGGYQCDNVGSDYYCSKQFWEGPNWGITNFDNFGL 313
Query: 3004 AMISLFVVSTFEGWPQLLY 3060
AM+++F T EGW ++LY
Sbjct: 314 AMLTVFQCVTLEGWTEVLY 332
Score = 91.7 bits (226), Expect = 2e-16
Identities = 81/343 (23%), Positives = 143/343 (41%), Gaps = 44/343 (12%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACKH---YPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVAL-- 3513
+ FE++I + I N ++LA Y S +L+ IF +F E V+KI+A
Sbjct: 99 KPFEWLILMTIFANCIALAVYTPYPYGDSNLTNQYLEKIEYIFLVIFTVECVMKIIAYGF 158
Query: 3514 --NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRG 3687
+P Y+ + WN+ D +VV + L G + R FRV+R ++L+S
Sbjct: 159 VAHPGAYLRNGWNILDFSIVVIGMVSTVLSVLMKEG---FDVKALRAFRVLRPLRLVSGV 215
Query: 3688 EGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKV-----------ALDDST 3831
++ +L + +++ L ++ALL++ + IYA+IG++ F GK+ +DD
Sbjct: 216 PSLQVVLNSILRAMIPLLHIALLVLFVIIIYAIIGLELFSGKMHKTCRHNMTDAIMDDPV 275
Query: 3832 SIHRN-------------------------NNFHSFPAAILVLFRSATGEAWQDIMLSCS 3936
NF +F A+L +F+ T E W +++ +
Sbjct: 276 PCGPGGYQCDNVGSDYYCSKQFWEGPNWGITNFDNFGLAMLTVFQCVTLEGWTEVLYNIE 335
Query: 3937 DREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLT 4116
D G+++ + YFIS +L +F V+NL + V+ F
Sbjct: 336 D---------------------AMGSSWQWIYFISMVILGAFFVMNLILGVLSGEFSKER 374
Query: 4117 RDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
G H +R + + D +G +LD +T I P
Sbjct: 375 EKAKARGDFHK---LREKQQIEDDLRG---YLDWITQAEDIEP 411
Score = 91.3 bits (225), Expect = 2e-16
Identities = 80/351 (22%), Positives = 148/351 (41%), Gaps = 26/351 (7%)
Frame = +1
Query: 262 KPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGF 441
+PFE+ I +I N + LA+ + Q Y L + + +F VF +E + K+ A F
Sbjct: 1050 QPFEYTIFTLIMINTVTLAM--KFYRQPEIYTQAL-DVLNMIFTAVFALEFIFKLAAFRF 1106
Query: 442 MFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKALRAFRVLRPLRLVSGVP 615
Y +AWN+ DFIIV+ + + S+++ + R FRV+R ++L+S
Sbjct: 1107 ----KNYFGDAWNVFDFIIVLGSFIDIVYSEVNPGSTIISINFFRLFRVMRLVKLLSRGE 1162
Query: 616 SLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPT 795
++ +L +++ L ++ALL++ + IYA+IG+++F G++A D T
Sbjct: 1163 GIRTLLWTFIKSFQALPYVALLIIMLFFIYAVIGMQVF-------------GKIAIDDET 1209
Query: 796 PCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSL 975
N NF +F A+L +F+ +
Sbjct: 1210 SI------------------------------------NRNNNFQSFPQAVLVLFRSATG 1233
Query: 976 EGWTDVMYWVN------------------DAVGREWPWIYFVTLVILGSFFVLNLVLGVL 1101
E W ++M + + G + + YF++ +L SF ++NL + V+
Sbjct: 1234 ESWQEIMMDCSVQPGKVKCDPNSDEALNTNGCGSDIAFPYFISFYVLCSFLIINLFVAVI 1293
Query: 1102 SGEF---SKEREKARARGLFQKFREKQQLEEDLKG---YLDWITQAEDIEP 1236
F +++ L + R + + D KG +LD +T I P
Sbjct: 1294 MDNFDYLTRDWSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISP 1344
Score = 81.6 bits (200), Expect = 2e-13
Identities = 63/254 (24%), Positives = 113/254 (43%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S+ F ++I +++ +NT LA +HY +DF ++ N+ F +F E +LK+ +L
Sbjct: 470 VKSQVFYWLIIVLVFLNTGVLATEHYNQPHWLDDFQEITNMFFIALFTMEMMLKMYSLGF 529
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD VV+GS ++ N + ++ R R++R+ K+ +
Sbjct: 530 QGYFVSLFNRFDCFVVIGSITEMIL--TNTHVMPPLGVSVLRCVRLLRVFKVTKYWRSLS 587
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAIL 3879
L+ + + S Q++ + LL+ L I+A++GMQ
Sbjct: 588 NLVASLLNSIQSIASLLLLLFLFIVIFALLGMQIL------------------------- 622
Query: 3880 VLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCS 4059
TGE W +M + +R GG++ A YFI F +C
Sbjct: 623 ------TGEDWNAVMY-----DGIRA--------YGGVSSF---GMLACFYFIILF-ICD 659
Query: 4060 FLVINLFVAVIMDN 4101
L +N+F+A+ +DN
Sbjct: 660 IL-LNVFLAIAVDN 672
Score = 72.8 bits (177), Expect = 9e-11
Identities = 34/64 (53%), Positives = 44/64 (68%)
Frame = +1
Query: 2260 SARPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSA 2439
SARPRRMSE A+ +PIP S+ FI S TN R+FC+ + NHS F N +L CI++SSA
Sbjct: 758 SARPRRMSEFNMATKKQPIPAGSAFFIFSQTNRIRIFCHWLCNHSTFGNVILVCIMISSA 817
Query: 2440 MLAA 2451
+ A
Sbjct: 818 ISGA 821
Score = 68.6 bits (166), Expect = 2e-09
Identities = 53/253 (20%), Positives = 97/253 (37%), Gaps = 17/253 (6%)
Frame = +1
Query: 1408 VKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGF 1587
V SQ F + + Y Q E + N+ F +F++E + K+ + F
Sbjct: 1047 VTSQPFEYTIFTLIMINTVTLAMKFYRQPEIYTQALDVLNMIFTAVFALEFIFKLAAFRF 1106
Query: 1588 TTYTTSQFNRFDCFVVISSILEFVLVYFDLMKP----LGVSVLRSARLLRIFKVTKYWTX 1755
Y +N FD +V+ S ++ V + + P + ++ R R++R+ K+
Sbjct: 1107 KNYFGDAWNVFDFIIVLGSFIDIV---YSEVNPGSTIISINFFRLFRVMRLVKLLSRGEG 1163
Query: 1756 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQA 1935
GMQVFG + NF +F QA
Sbjct: 1164 IRTLLWTFIKSFQALPYVALLIIMLFFIYAVIGMQVFGKIAIDDETSINRNNNFQSFPQA 1223
Query: 1936 LLTVFQILTGEDWNTVMY-------------HGIESFGGVGTLGVIVCIYYIVLFICGNY 2076
+L +F+ TGE W +M + E+ G I Y+I ++ ++
Sbjct: 1224 VLVLFRSATGESWQEIMMDCSVQPGKVKCDPNSDEALNTNGCGSDIAFPYFISFYVLCSF 1283
Query: 2077 ILLNVFLAIAVDN 2115
+++N+F+A+ +DN
Sbjct: 1284 LIINLFVAVIMDN 1296
Score = 65.1 bits (157), Expect = 2e-08
Identities = 91/512 (17%), Positives = 180/512 (34%), Gaps = 55/512 (10%)
Frame = +1
Query: 1483 YGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTT----YTTSQFNRFDCFVVISSIL 1650
YG S + + F+++F++E ++K+ + GF Y + +N D +V+ ++
Sbjct: 124 YGDSNLTNQYLEKIEYIFLVIFTVECVMKIIAYGFVAHPGAYLRNGWNILDFSIVVIGMV 183
Query: 1651 EFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXX 1830
VL + + V LR+ R+LR ++
Sbjct: 184 STVLSVL-MKEGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSILRAMIPLLHIALLVLFV 242
Query: 1831 XXXXXXXGMQVFGGKFNFNPQQPKPRA--------------------------------- 1911
G+++F GK + + A
Sbjct: 243 IIIYAIIGLELFSGKMHKTCRHNMTDAIMDDPVPCGPGGYQCDNVGSDYYCSKQFWEGPN 302
Query: 1912 ----NFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYI 2079
NFD F A+LTVFQ +T E W V+Y+ ++ G IY+I + I G +
Sbjct: 303 WGITNFDNFGLAMLTVFQCVTLEGWTEVLYNIEDAMGSSWQW-----IYFISMVILGAFF 357
Query: 2080 LLNVFLAIAVDNLADADSLTNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-- 2253
++N+ L + + A
Sbjct: 358 VMNLILGVLSGEFSKEREKAKARGDFHKLREKQQIEDDLRGYLDWITQAEDIEPETDEPK 417
Query: 2254 MTSARPRRMSEVPAASTVK---------PIPKASSLFILSHTNSFRVFCNMVVNHSYFTN 2406
M + ++ SE+ + ++ + + L R C V F
Sbjct: 418 MQDGKTKQQSEMESTDQLEGDEEGVQQESLWRRKKLDFDRVNRRMRRACRKAVKSQVFYW 477
Query: 2407 AVLFCILVSSAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSF 2586
++ + +++ +LA E Q + + + FF ++FT+E+ LK+ G +G F
Sbjct: 478 LIIVLVFLNTGVLATEHYNQPHWLDDF-QEITNMFFIALFTMEMMLKMYSLGF---QGYF 533
Query: 2587 CRNAFNLLDILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQC 2757
+ FN D VV S+T +L + K L ++V
Sbjct: 534 V-SLFNRFDCFVVIGSITEMILTNTHVMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVAS 592
Query: 2758 VIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKG 2853
++ ++++I +++L+ F+ +FA++G+Q+ G
Sbjct: 593 LLNSIQSIASLLLLLFLFIVIFALLGMQILTG 624
Score = 64.7 bits (156), Expect = 2e-08
Identities = 54/223 (24%), Positives = 100/223 (44%), Gaps = 10/223 (4%)
Frame = +1
Query: 493 IIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHI 672
I+V I + S I S+ VK LR RVLRPLR ++ L+ V+ ++ A+ + +I
Sbjct: 808 ILVCIMISSAISGAFSV----VKVLRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNI 863
Query: 673 ALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSD-S 849
L+ + ++A++G++LF GK C ++ + +CQ +
Sbjct: 864 VLVTSLLQFVFAVVGVQLFKGKFFY-----------------CTDASKMTKEECQGTYLE 906
Query: 850 LTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREW 1029
N + W +FD+ AMLT+F + EGW ++ + D+ +
Sbjct: 907 FENGNINKPIMKERNWCQQR---FHFDDVAKAMLTLFTVSTFEGWPSLLDYSIDSNKEDH 963
Query: 1030 PWI---------YFVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
I Y++ +I+ +FF++N+ +G + F E E+
Sbjct: 964 GPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNEGEQ 1006
Score = 48.1 bits (113), Expect = 0.002
Identities = 36/188 (19%), Positives = 80/188 (42%), Gaps = 30/188 (15%)
Frame = +1
Query: 3631 INFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-- 3804
+ R+ RV+R ++ ++R +G++ ++ + + + + + L+ LL F++AV+G+Q F
Sbjct: 825 VKVLRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTSLLQFVFAVVGVQLFKG 884
Query: 3805 ----------------------------GKVALDDSTSIHRNNNFHSFPAAILVLFRSAT 3900
K + + + +F A+L LF +T
Sbjct: 885 KFFYCTDASKMTKEECQGTYLEFENGNINKPIMKERNWCQQRFHFDDVAKAMLTLFTVST 944
Query: 3901 GEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLF 4080
E W ++ D D +D+ G ++ R Y+I + ++ +F ++N+F
Sbjct: 945 FEGWPSLL-------DYSIDSNKEDH--GPIHNFR---PIVAAYYIIYIIIIAFFMVNIF 992
Query: 4081 VAVIMDNF 4104
V ++ F
Sbjct: 993 VGFVIVTF 1000
Score = 42.7 bits (99), Expect = 0.10
Identities = 21/72 (29%), Positives = 39/72 (54%), Gaps = 4/72 (5%)
Frame = +1
Query: 1906 RANFDTFVQALLTVFQILTGEDWNTVMYHGIES----FGGVGTLGVIVCIYYIVLFICGN 2073
R +FD +A+LT+F + T E W +++ + I+S G + IV YYI+ I
Sbjct: 926 RFHFDDVAKAMLTLFTVSTFEGWPSLLDYSIDSNKEDHGPIHNFRPIVAAYYIIYIIIIA 985
Query: 2074 YILLNVFLAIAV 2109
+ ++N+F+ +
Sbjct: 986 FFMVNIFVGFVI 997
>gi|46576355|sp|O57483|CCAS_RANCA Voltage-dependent L-type calcium
channel alpha-1S subunit (Voltage-gated calcium channel
alpha subunit Cav1.1) (FGalpha1S)
gi|2708678|gb|AAC36126.1| dihydropyridine receptor [Rana catesbeiana]
Length = 1688
Score = 971 bits (2509), Expect = 0.0
Identities = 489/823 (59%), Positives = 610/823 (73%), Gaps = 11/823 (1%)
Frame = +1
Query: 2260 SARPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSA 2439
S RPR ++E+ P+P+ASS FI S TN RV C+ ++N + FTN +L IL+SS
Sbjct: 753 SPRPRPLAELQLKEKAVPMPEASSFFIFSPTNKIRVLCHRIINATTFTNFILLFILLSSI 812
Query: 2440 MLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDIL 2619
LAAEDP+Q S RN +L+ D FT +FT EI LK+ +G HKGSFCRN+FN+LD+
Sbjct: 813 SLAAEDPIQPESFRNKVLSKLDIVFTVIFTTEIVLKMTAYGAFLHKGSFCRNSFNILDLS 872
Query: 2620 VVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLV 2799
VV VSL S + + A+S AINRAKGLKHVVQC+ VA+KTIGNI+LV
Sbjct: 873 VVGVSLISMGIESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCLFVAIKTIGNIVLV 932
Query: 2800 TFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNND 2979
T +LQFMF+ IGVQLFKG F+ C D +K+T ECRG + +DG+P + RVWS++D
Sbjct: 933 TTLLQFMFSCIGVQLFKGKFYSCTDTTKITADECRGYFFVAKDGNPAHMEAVPRVWSHSD 992
Query: 2980 FNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXX 3159
F+FDNV M+SLF +STFEGWPQLLY AIDS+ ED GPI+N R +A+
Sbjct: 993 FHFDNVLSGMMSLFTISTFEGWPQLLYRAIDSHAEDMGPIYNYRIEIAVFFIVYIILIAF 1052
Query: 3160 XXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWF 3339
GFVIVTFQ +GE+EY++CELDKNQR+C+++ALKA+P RRYIP+N QY++W+
Sbjct: 1053 FMMNIFVGFVIVTFQEQGEQEYKDCELDKNQRQCVQYALKARPLRRYIPKNPHQYKIWYV 1112
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
VTS FEY++F +I +NT+SL +HY + F D+ N+ FTG+F E LK+ A
Sbjct: 1113 VTSSYFEYLMFFLITLNTISLGMQHYGQTAEFSYMSDILNVAFTGIFTVEMFLKLAAFKA 1172
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGG---------TNLISINFFRLFRVMRLVK 3672
K Y D WNVFD L+V+GS ID+ +++ G ++ ISI FFRLFRV+RLVK
Sbjct: 1173 KGYFGDPWNVFDFLIVIGSVIDVILSEIDTPGIPATPGAEESSRISITFFRLFRVLRLVK 1232
Query: 3673 LLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNN 3852
LLSRGEG+RTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL D T I+RN+N
Sbjct: 1233 LLSRGEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALVDGTHINRNSN 1292
Query: 3853 FHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPY 4032
F +FP A+L+LFR ATGEAWQ+I+L+CS + CDPMSD + G E CG +FAY Y
Sbjct: 1293 FQTFPQAVLLLFRCATGEAWQEILLACSYGK--LCDPMSD-FQPG--EEYTCGTSFAYFY 1347
Query: 4033 FISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHL 4212
FISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+W+EYDP+AKGRIKHL
Sbjct: 1348 FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHL 1407
Query: 4213 DVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTE 4392
DVVTLLR+I PPLGFGK CPHR+ACKRLVSMNMPLNSDGTV FNATLF+LVRT LKI TE
Sbjct: 1408 DVVTLLRRIQPPLGFGKFCPHRVACKRLVSMNMPLNSDGTVTFNATLFSLVRTALKIKTE 1467
Query: 4393 GNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKR 4572
GN +++NE+LR IK+IWKRT LLD+V+PP G +D+VTVGKFYA FLIQ++FR+FKKR
Sbjct: 1468 GNFEQSNEELRMIIKKIWKRTSMKLLDQVIPPIG-DDEVTVGKFYAIFLIQEHFRKFKKR 1526
Query: 4573 KEMEAKGVLPAQTPQAMALQAGLRTLHEI--GPELKRAISGNL 4695
+E E G P + + +QAGLRT+ E EL+RAISG+L
Sbjct: 1527 QE-EYYGYRPKKNANNVEIQAGLRTIEEEEGEGELQRAISGDL 1568
Score = 666 bits (1718), Expect = 0.0
Identities = 349/658 (53%), Positives = 441/658 (66%), Gaps = 17/658 (2%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP RK CI+IVEWKPFE +IL I ANC+ALAI+ P P D++ N++LE +EY+F+ +F
Sbjct: 38 NPFRKFCINIVEWKPFEMIILLTIFANCVALAIFLPMPEDDTNSTNSVLEKVEYIFLFIF 97
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMS----------IQGF 552
TIE LKIVA GF+ H AYLRN WNILDF IV +G+ S +L ++S GF
Sbjct: 98 TIESFLKIVAYGFILHTDAYLRNGWNILDFTIVSVGVFSVLLEQISKLQGLPAPGKSSGF 157
Query: 553 DVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFC 732
+VKALRAFRVLRPLRLVSGVPSLQVVLN+I++AMIPLLHIALLVLF+I+IYAI+GLELF
Sbjct: 158 NVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMIPLLHIALLVLFMIIIYAIVGLELFS 217
Query: 733 GKLHSTCIDPATGQLAQKD---PTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPG 903
GK+H TC T A D P PC + +G +C + S EC WPG
Sbjct: 218 GKMHKTCYFKDTDITATVDNEKPAPCSSTGQGR--QCSINGS--------ECRG--WWPG 265
Query: 904 PNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLN 1083
PNNGIT+FDNFG AMLTV+QC+++EGWT+V+YWVNDA+G EWPWIYFV+L++LGSFFVLN
Sbjct: 266 PNNGITHFDNFGFAMLTVYQCITMEGWTEVLYWVNDAIGNEWPWIYFVSLILLGSFFVLN 325
Query: 1084 LVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAE----DIEPVNEDE 1251
LVLGVLSGEF+KEREKA++RG FQ RE+Q ++EDL+GYLDWIT AE D+EP +
Sbjct: 326 LVLGVLSGEFTKEREKAKSRGAFQMLREQQAMDEDLRGYLDWITHAEVMDPDMEPRDGFS 385
Query: 1252 QEDEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYW 1431
Q +E ++T W ++R + LVKS+ FYW
Sbjct: 386 QLEEGGSETDSLYEIEGINKFIAFFRQWRLWHRLLRRKSR----------DLVKSRFFYW 435
Query: 1432 XXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQF 1611
+EH+ Q + L Q +AN + LF+MEM++K+Y+LGF +Y S F
Sbjct: 436 LVIIIILLNTVIIATEHHHQPDSLTKAQDIANEVLLALFTMEMIVKIYALGFQSYFMSLF 495
Query: 1612 NRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXX 1791
NRFD FVV + +LE +LV D+M PLG+SVLR RLLRIFK+T+YWT
Sbjct: 496 NRFDSFVVCTGLLEVMLVASDIMSPLGISVLRCIRLLRIFKITRYWTSLNNLVASLLNSV 555
Query: 1792 XXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGED 1971
GMQ+FGGKF+F + + R+ FDTF QAL+TVFQILTGED
Sbjct: 556 RSIASLLLLLFLFMIIFALLGMQMFGGKFDFEDLEVR-RSTFDTFPQALITVFQILTGED 614
Query: 1972 WNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNA 2145
W VMY+GI ++GG G+ VCIY+I+LF+CGNYILLNVFLAIAVDNLA+A++LT+A
Sbjct: 615 WTAVMYNGIMAYGGPTYSGMSVCIYFIILFVCGNYILLNVFLAIAVDNLAEAENLTSA 672
Score = 124 bits (312), Expect = 2e-26
Identities = 93/342 (27%), Positives = 159/342 (46%), Gaps = 10/342 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V N IR LC I+ F IL I + I+L
Sbjct: 755 RPRPLAELQLKEKAVPMPEASSFFIFSPTNKIRVLCHRIINATTFTNFILLFILLSSISL 814
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P Q ++N +L ++ VF V+FT E VLK+ A G H ++ RN++NILD
Sbjct: 815 AAEDPI--QPESFRNKVLSKLDIVFTVIFTTEIVLKMTAYGAFLHKGSFCRNSFNILDLS 872
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S + +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 873 VVGVSLISMGIESSAIS--VVKILRVLRVLRPLRAINRAKGLKHVVQCLFVAIKTIGNIV 930
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLT 855
L+ + +++ IG++LF GK +S C T+ +A +C+ +
Sbjct: 931 LVTTLLQFMFSCIGVQLFKGKFYS-----------------CTDTTKITADECRGYFFVA 973
Query: 856 NMGVRWECSS-NTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWP 1032
G + W ++ +FDN M+++F + EGW ++Y D+ +
Sbjct: 974 KDGNPAHMEAVPRVW---SHSDFHFDNVLSGMMSLFTISTFEGWPQLLYRAIDSHAEDMG 1030
Query: 1033 WIY---------FVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
IY F+ +IL +FF++N+ +G + F ++ E+
Sbjct: 1031 PIYNYRIEIAVFFIVYIILIAFFMMNIFVGFVIVTFQEQGEQ 1072
Score = 101 bits (252), Expect = 2e-19
Identities = 70/271 (25%), Positives = 131/271 (47%), Gaps = 10/271 (3%)
Frame = +1
Query: 3319 QYRVWW---------FVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFT 3471
Q+R+W V SR F +++ +II++NTV +A +H+ D+ N +
Sbjct: 412 QWRLWHRLLRRKSRDLVKSRFFYWLVIIIILLNTVIIATEHHHQPDSLTKAQDIANEVLL 471
Query: 3472 GVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLF 3651
+F E ++KI AL ++Y +N FD VV +++ + + + I+ R
Sbjct: 472 ALFTMEMIVKIYALGFQSYFMSLFNRFDSFVVCTGLLEVML--VASDIMSPLGISVLRCI 529
Query: 3652 RVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDS 3828
R++R+ K+ + L+ + + S +++ + LL+ L I+A++GMQ F GK +D
Sbjct: 530 RLLRIFKITRYWTSLNNLVASLLNSVRSIASLLLLLFLFMIIFALLGMQMFGGKFDFEDL 589
Query: 3829 TSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRC 4008
R + F +FP A++ +F+ TGE W +M + GG S
Sbjct: 590 EV--RRSTFDTFPQALITVFQILTGEDWTAVM-------------YNGIMAYGGPTYSGM 634
Query: 4009 GNNFAYPYFISFFMLCSFLVINLFVAVIMDN 4101
YFI F+ +++++N+F+A+ +DN
Sbjct: 635 S---VCIYFIILFVCGNYILLNVFLAIAVDN 662
Score = 95.5 bits (236), Expect = 1e-17
Identities = 73/282 (25%), Positives = 126/282 (43%), Gaps = 25/282 (8%)
Frame = +1
Query: 2305 VKPIPKAS-SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR 2481
V P P+ +LF L N FR FC +V F +L I + LA P+ + T
Sbjct: 21 VPPPPRPPRALFCLGLQNPFRKFCINIVEWKPFEMIILLTIFANCVALAIFLPMPEDDTN 80
Query: 2482 --NMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLR 2655
N +L +Y F +FT+E LK++ +G + H ++ RN +N+LD +V+V + S +L
Sbjct: 81 STNSVLEKVEYIFLFIFTIESFLKIVAYGFILHTDAYLRNGWNILDFTIVSVGVFSVLLE 140
Query: 2656 TDAMSXXXXXXXXXXXXXXXA------------INRAKGLKHVVQCVIVAVKTIGNIMLV 2799
+ A ++ L+ V+ +I A+ + +I L+
Sbjct: 141 QISKLQGLPAPGKSSGFNVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMIPLLHIALL 200
Query: 2800 TFMLQFMFAIIGVQLFKG-----TFFLCNDLSKMTEAECRGEYIHYEDGDPTK-PVSKKR 2961
+ ++AI+G++LF G +F D++ + E G S+ R
Sbjct: 201 VLFMIIIYAIVGLELFSGKMHKTCYFKDTDITATVDNEKPAPCSSTGQGRQCSINGSECR 260
Query: 2962 VW----SNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
W +N +FDN G AM++++ T EGW ++LY D+
Sbjct: 261 GWWPGPNNGITHFDNFGFAMLTVYQCITMEGWTEVLYWVNDA 302
Score = 92.4 bits (228), Expect = 1e-16
Identities = 74/325 (22%), Positives = 135/325 (40%), Gaps = 28/325 (8%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP + +V FE+L+ F+I N I+L + + Y + +L F +F
Sbjct: 1103 NPHQYKIWYVVTSSYFEYLMFFLITLNTISLGMQHYGQTAEFSYMSDILNV---AFTGIF 1159
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGF---------- 552
T+E LK+ A F Y + WN+ DF+IV+ ++ ILS++ G
Sbjct: 1160 TVEMFLKLAA----FKAKGYFGDPWNVFDFLIVIGSVIDVILSEIDTPGIPATPGAEESS 1215
Query: 553 --DVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLEL 726
+ R FRVLR ++L+S ++ +L +++ L ++ALL++ + IYA+IG+++
Sbjct: 1216 RISITFFRLFRVLRLVKLLSRGEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQV 1275
Query: 727 FCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGP 906
F G++A D T
Sbjct: 1276 F-------------GKIALVDGTHI----------------------------------- 1287
Query: 907 NNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVN----------------DAVGREWPWI 1038
N +NF F A+L +F+C + E W +++ + G + +
Sbjct: 1288 -NRNSNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPMSDFQPGEEYTCGTSFAYF 1346
Query: 1039 YFVTLVILGSFFVLNLVLGVLSGEF 1113
YF++ +L +F ++NL + V+ F
Sbjct: 1347 YFISFYMLCAFLIINLFVAVIMDNF 1371
Score = 87.8 bits (216), Expect = 3e-15
Identities = 90/364 (24%), Positives = 152/364 (41%), Gaps = 58/364 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLAC---KHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE +I L I N V+LA + L+ IF +F E+ LKIVA
Sbjct: 51 KPFEMIILLTIFANCVALAIFLPMPEDDTNSTNSVLEKVEYIFLFIFTIESFLKIVAYGF 110
Query: 3511 -LNPKNYISDRWNVFDLLVV-VGSF------IDITYGKLNPGGTNLISINFFRLFRVMRL 3666
L+ Y+ + WN+ D +V VG F I G PG ++ ++ R FRV+R
Sbjct: 111 ILHTDAYLRNGWNILDFTIVSVGVFSVLLEQISKLQGLPAPGKSSGFNVKALRAFRVLRP 170
Query: 3667 VKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFG------------- 3807
++L+S ++ +L + +K+ L ++ALL++ + IYA++G++ F
Sbjct: 171 LRLVSGVPSLQVVLNSIIKAMIPLLHIALLVLFMIIIYAIVGLELFSGKMHKTCYFKDTD 230
Query: 3808 --------KVALDDSTSIHR----------------NN---NFHSFPAAILVLFRSATGE 3906
K A ST R NN +F +F A+L +++ T E
Sbjct: 231 ITATVDNEKPAPCSSTGQGRQCSINGSECRGWWPGPNNGITHFDNFGFAMLTVYQCITME 290
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVA 4086
W +++ +D GN + + YF+S +L SF V+NL +
Sbjct: 291 GWTEVLYWVND---------------------AIGNEWPWIYFVSLILLGSFFVLNLVLG 329
Query: 4087 VIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPL----G 4254
V+ F T++ + +R D D +G +LD +T + P + G
Sbjct: 330 VLSGEF---TKEREKAKSRGAFQMLREQQAMDEDLRG---YLDWITHAEVMDPDMEPRDG 383
Query: 4255 FGKL 4266
F +L
Sbjct: 384 FSQL 387
Score = 71.6 bits (174), Expect = 2e-10
Identities = 55/236 (23%), Positives = 96/236 (40%), Gaps = 23/236 (9%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HYGQ+ + + N+ F +F++EM LK+ + Y +N FD +VI S+++
Sbjct: 1136 QHYGQTAEFSYMSDILNVAFTGIFTVEMFLKLAAFKAKGYFGDPWNVFDFLIVIGSVIDV 1195
Query: 1657 VLVYFDL-----------MKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXX 1803
+L D + ++ R R+LR+ K+
Sbjct: 1196 ILSEIDTPGIPATPGAEESSRISITFFRLFRVLRLVKLLSRGEGVRTLLWTFIKSFQALP 1255
Query: 1804 XXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTV 1983
GMQVFG + +NF TF QA+L +F+ TGE W +
Sbjct: 1256 YVALLIVMLFFIYAVIGMQVFGKIALVDGTHINRNSNFQTFPQAVLLLFRCATGEAWQEI 1315
Query: 1984 MY--------HGIESF--GGVGTLGVIVCIYYIVLF--ICGNYILLNVFLAIAVDN 2115
+ + F G T G +Y + F +C ++++N+F+A+ +DN
Sbjct: 1316 LLACSYGKLCDPMSDFQPGEEYTCGTSFAYFYFISFYMLCA-FLIINLFVAVIMDN 1370
Score = 50.8 bits (120), Expect = 4e-04
Identities = 52/233 (22%), Positives = 99/233 (42%), Gaps = 3/233 (1%)
Frame = +1
Query: 2380 VVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVF 2559
+V +F V+ IL+++ ++A E Q +S + + ++FT+E+ +K+
Sbjct: 427 LVKSRFFYWLVIIIILLNTVIIATEHHHQPDSLTKA-QDIANEVLLALFTMEMIVKIYAL 485
Query: 2560 GLVFHKGSFCRNAFNLLDILVVAVSLTSFVL-RTDAMSXXXXXXXX-XXXXXXXAINRA- 2730
G S+ + FN D VV L +L +D MS I R
Sbjct: 486 GFQ----SYFMSLFNRFDSFVVCTGLLEVMLVASDIMSPLGISVLRCIRLLRIFKITRYW 541
Query: 2731 KGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGE 2910
L ++V ++ +V++I +++L+ F+ +FA++G+Q+F G F
Sbjct: 542 TSLNNLVASLLNSVRSIASLLLLLFLFMIIFALLGMQMFGGKF----------------- 584
Query: 2911 YIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAI 3069
+ED + + FD A+I++F + T E W ++Y I
Sbjct: 585 --DFEDLEVRRS------------TFDTFPQALITVFQILTGEDWTAVMYNGI 623
Score = 42.0 bits (97), Expect = 0.17
Identities = 45/233 (19%), Positives = 88/233 (37%), Gaps = 38/233 (16%)
Frame = +1
Query: 1525 NLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLG 1692
++ F ++F+ E++LKM + G ++ + FN D VV S++ + +
Sbjct: 834 DIVFTVIFTTEIVLKMTAYGAFLHKGSFCRNSFNILDLSVVGVSLISMGIESSAISV--- 890
Query: 1693 VSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGG 1872
V +LR R+LR + G+Q+F G
Sbjct: 891 VKILRVLRVLRPLRAINRAKGLKHVVQCLFVAIKTIGNIVLVTTLLQFMFSCIGVQLFKG 950
Query: 1873 KF----------------------NFNP--QQPKPRA------NFDTFVQALLTVFQILT 1962
KF + NP + PR +FD + ++++F I T
Sbjct: 951 KFYSCTDTTKITADECRGYFFVAKDGNPAHMEAVPRVWSHSDFHFDNVLSGMMSLFTIST 1010
Query: 1963 GEDWNTVMYHGIES----FGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
E W ++Y I+S G + + + +++IV I + ++N+F+ +
Sbjct: 1011 FEGWPQLLYRAIDSHAEDMGPIYNYRIEIAVFFIVYIILIAFFMMNIFVGFVI 1063
>gi|11279259|pir||T43262 calcium channel alpha-1 chain, L-type -
Stylophora pistillata
gi|4204978|gb|AAD11470.1| L-type calcium channel alpha-1 subunit
[Stylophora pistillata]
Length = 1891
Score = 970 bits (2507), Expect = 0.0
Identities = 479/801 (59%), Positives = 602/801 (74%), Gaps = 3/801 (0%)
Frame = +1
Query: 2311 PIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI 2490
P+P S+LFI S TN FRV C + ++YF N +L I+VSS +LAAEDPL A++ RN +
Sbjct: 823 PMPPESALFIFSPTNIFRVVCYKIATNTYFVNFILCLIIVSSILLAAEDPLNASAKRNQV 882
Query: 2491 LNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMS 2670
LNYFDYFFTSVFT EI +K I +GL+ HKGSFCR+AFNLLD+LVV+VS+ S LRT S
Sbjct: 883 LNYFDYFFTSVFTFEILVKFISYGLILHKGSFCRSAFNLLDLLVVSVSVISISLRTSQFS 942
Query: 2671 XXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFK 2850
AINRAKGLKHVVQ V VAVKTIGNI LVT + QF+FA+IGVQLFK
Sbjct: 943 VVRILRVLRVLRPLRAINRAKGLKHVVQSVFVAVKTIGNIKLVTMLFQFLFAVIGVQLFK 1002
Query: 2851 GTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVS 3030
GTFF CND +T EC+G YI ++ + PV K+R W +DFNFDNVG+AM++LF V
Sbjct: 1003 GTFFSCNDEKILTAEECQGNYIDFKGPGLSNPVVKEREWRRHDFNFDNVGNAMLTLFTVM 1062
Query: 3031 TFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIVTFQNE 3210
TFEGWP +L +IDS E DKGP N+R VA+ GFVIVTFQ+E
Sbjct: 1063 TFEGWPGILENSIDSTEVDKGPNQNNRPWVAIYYIIYIIIIAFFMVNIFVGFVIVTFQSE 1122
Query: 3211 GEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMN 3390
G E++ CELDKNQR+CIEFALKAKP +RYIP NRLQ+ +W VTS+AFEY+IF IV N
Sbjct: 1123 GREEFKGCELDKNQRQCIEFALKAKPLKRYIPENRLQFHIWPVVTSQAFEYLIFAFIVCN 1182
Query: 3391 TVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVV 3570
TV L ++Y + + LD FN+ FT VF E +LK++A PKNY +DRWN+FD ++VV
Sbjct: 1183 TVVLMMQYYQEPKLYTRVLDGFNIGFTAVFLLECILKLIAFKPKNYFTDRWNLFDFIIVV 1242
Query: 3571 GSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVA 3750
GS IDIT +++ + + FFRLFR +RLVKLL++G GI+TLLWTF+KSFQALPYVA
Sbjct: 1243 GSIIDITMNEVS--SEQMFAFGFFRLFRALRLVKLLNQGSGIKTLLWTFIKSFQALPYVA 1300
Query: 3751 LLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLS 3930
LLIV++FFIYAVIGMQ FG++A++ T+I+RNNNF +FP +++VLFRSATGE WQ IML+
Sbjct: 1301 LLIVMMFFIYAVIGMQMFGRIAINSDTAINRNNNFQTFPQSLMVLFRSATGENWQQIMLA 1360
Query: 3931 CSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNFDY 4110
C+ R+DV+CD +D GL CG++FAY YF+SF+ +CSFL+INLFVAVIMDNFDY
Sbjct: 1361 CTHRDDVKCDQNADPQEPSGL----CGSDFAYFYFVSFYSICSFLIINLFVAVIMDNFDY 1416
Query: 4111 LTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACK 4290
LTRDWSILGPHHL+E+VR+WSEYDPDA G +KH+D+VT+L++I+PPLGFGK CPHR ACK
Sbjct: 1417 LTRDWSILGPHHLDEYVRVWSEYDPDAHGCVKHVDIVTVLKRIAPPLGFGKFCPHREACK 1476
Query: 4291 RLVSMNMPLNSDGTVCFNATLFALVRTNLKIYT---EGNIDEANEQLRSAIKRIWKRTHK 4461
RLV+MNM L DG V FNATLF L+R++L I +G+ID+ANE++R+ I RIW +T
Sbjct: 1477 RLVTMNMGLTKDGMVDFNATLFGLIRSSLNIKRPEGKGSIDKANEEVRNIILRIWPKTSM 1536
Query: 4462 DLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEMEAKGVLPAQTPQAMALQAGL 4641
+LLD+VV P+G DDVTVGKFYAT+LIQ+YFRRFK R++ + + P MALQAGL
Sbjct: 1537 ELLDKVVQPSGVRDDVTVGKFYATYLIQEYFRRFKARQKAQNQANEP-HGNSTMALQAGL 1595
Query: 4642 RTLHEIGPELKRAISGNLETD 4704
RTLH +GP+L+RAISG L +D
Sbjct: 1596 RTLHGLGPQLRRAISGQLGSD 1616
Score = 657 bits (1696), Expect = 0.0
Identities = 346/655 (52%), Positives = 427/655 (64%), Gaps = 16/655 (2%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR I++VEWKPF+ +IL I ANC ALA ++P P +DS N LE EYVF+ VF
Sbjct: 68 NPIRSAAINLVEWKPFDVMILITIFANCAALAAFEPLPEKDSSEINDNLEVAEYVFLAVF 127
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKALRAF 576
T+E VLKI+A GF+FHP AYLRN WNILDF+IVV+GL +TIL K ++ FDVKALRAF
Sbjct: 128 TMEAVLKIIAYGFLFHPGAYLRNGWNILDFVIVVVGL-ATILVKATLSSGSFDVKALRAF 186
Query: 577 RVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI 756
RVLRPLRLVSGVPSLQVVLN+I++A+IPL HIALLV+FV++IYAIIG+ELF G+LH TC
Sbjct: 187 RVLRPLRLVSGVPSLQVVLNSIIKALIPLFHIALLVVFVVIIYAIIGVELFMGRLHKTCY 246
Query: 757 DPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNF 936
D TG + ++P PC + + G F+C + G W GPN+GITNFDN
Sbjct: 247 DNVTGAESFEEPHPCSSGSSG--FQCDKAAGQVCEG---------GWKGPNHGITNFDNI 295
Query: 937 GLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFS 1116
GLA +TVFQC++LEGWTDV+YW+NDAVG WPW+YFVTL+I GSFFVLNLVLGVLSGEF+
Sbjct: 296 GLACMTVFQCITLEGWTDVLYWINDAVGNSWPWVYFVTLIIWGSFFVLNLVLGVLSGEFA 355
Query: 1117 KEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVAQTXXXXXX 1296
KE+ + + G FQKFREKQQ+E+ GYLDWITQAEDIE +E E DE A
Sbjct: 356 KEKARRQKSGEFQKFREKQQVEDAYNGYLDWITQAEDIEGDSESESGDESKASKKTSSRQ 415
Query: 1297 XXXXXXXXXXXXPSK------------WAARMKR-LEKLNXXXXXXXXXLVKSQTFYWXX 1437
+ W K+ L+K + VK+Q FYW
Sbjct: 416 SRTEDIEMIDRNERQDSISQHDTHHYGWCHNEKKVLKKWHHRRQTELRKAVKTQAFYWIV 475
Query: 1438 XXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNR 1617
EHY Q +WL F +AN F+ +F++EM++KMY LGF Y S FNR
Sbjct: 476 IVVVFLNSLTLALEHYDQPDWLTKFLDIANKLFLGIFTIEMIVKMYCLGFHGYFASLFNR 535
Query: 1618 FDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXX 1797
FDC VVISS+LE + P+G+SVLR RLLRIFKVT+YW+
Sbjct: 536 FDCLVVISSLLELAITEALKQPPIGISVLRCIRLLRIFKVTRYWSSLSNLVASLLNSMRS 595
Query: 1798 XXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWN 1977
GMQ+FGGKFN + + PR+NFD+F +AL+TVFQILTGEDWN
Sbjct: 596 IAGLLLLLSLFMLICSLLGMQIFGGKFNTDDDE-IPRSNFDSFWRALITVFQILTGEDWN 654
Query: 1978 TVMYHGIESFGGVGTLG-VIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLT 2139
VMY GI ++GG+G G I +Y+I L + GNYILLNVFLAIAVDNLADA++LT
Sbjct: 655 AVMYDGIRAWGGIGEGGSAIAILYFIFLVVVGNYILLNVFLAIAVDNLADAENLT 709
Score = 121 bits (304), Expect = 2e-25
Identities = 90/322 (27%), Positives = 150/322 (45%), Gaps = 22/322 (6%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
N R +C I F IL +I + I LA P A S +N +L +Y F VF
Sbjct: 837 NIFRVVCYKIATNTYFVNFILCLIIVSSILLAAEDPLNA--SAKRNQVLNYFDYFFTSVF 894
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
T E ++K ++ G + H ++ R+A+N+LD ++V + ++S +S + Q V+ LR RV
Sbjct: 895 TFEILVKFISYGLILHKGSFCRSAFNLLDLLVVSVSVIS--ISLRTSQFSVVRILRVLRV 952
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLR ++ L+ V+ ++ A+ + +I L+ + ++A+IG++LF
Sbjct: 953 LRPLRAINRAKGLKHVVQSVFVAVKTIGNIKLVTMLFQFLFAVIGVQLF----------- 1001
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSN---TTWPGPNNGIT---- 921
+G+ F C LT EC N PG +N +
Sbjct: 1002 -----------------KGTFFSCNDEKILT----AEECQGNYIDFKGPGLSNPVVKERE 1040
Query: 922 ------NFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAV---------GREWPWIYFVTLV 1056
NFDN G AMLT+F ++ EGW ++ D+ R W IY++ +
Sbjct: 1041 WRRHDFNFDNVGNAMLTLFTVMTFEGWPGILENSIDSTEVDKGPNQNNRPWVAIYYIIYI 1100
Query: 1057 ILGSFFVLNLVLGVLSGEFSKE 1122
I+ +FF++N+ +G + F E
Sbjct: 1101 IIIAFFMVNIFVGFVIVTFQSE 1122
Score = 120 bits (301), Expect = 4e-25
Identities = 74/256 (28%), Positives = 136/256 (52%), Gaps = 2/256 (0%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V ++AF +++ +++ +N+++LA +HY FLD+ N +F G+F E ++K+ L
Sbjct: 466 VKTQAFYWIVIVVVFLNSLTLALEHYDQPDWLTKFLDIANKLFLGIFTIEMIVKMYCLGF 525
Query: 3520 KNYISDRWNVFDLLVVVGSFID--ITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
Y + +N FD LVV+ S ++ IT P I I+ R R++R+ K+
Sbjct: 526 HGYFASLFNRFDCLVVISSLLELAITEALKQPP----IGISVLRCIRLLRIFKVTRYWSS 581
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAA 3873
+ L+ + + S +++ + LL+ L I +++GMQ FG D I R +NF SF A
Sbjct: 582 LSNLVASLLNSMRSIAGLLLLLSLFMLICSLLGMQIFGGKFNTDDDEIPR-SNFDSFWRA 640
Query: 3874 ILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFML 4053
++ +F+ TGE W +M + +R GG+ E G+ A YFI ++
Sbjct: 641 LITVFQILTGEDWNAVMY-----DGIRA--------WGGIGEG--GSAIAILYFIFLVVV 685
Query: 4054 CSFLVINLFVAVIMDN 4101
+++++N+F+A+ +DN
Sbjct: 686 GNYILLNVFLAIAVDN 701
Score = 100 bits (248), Expect = 5e-19
Identities = 80/271 (29%), Positives = 126/271 (45%), Gaps = 15/271 (5%)
Frame = +1
Query: 2293 AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPL--Q 2466
+ +TV+P +L LS N R +V F +L I + A LAA +PL +
Sbjct: 51 SGNTVRP---KRALLCLSLGNPIRSAAINLVEWKPFDVMILITIFANCAALAAFEPLPEK 107
Query: 2467 ANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSF 2646
+S N L +Y F +VFT+E LK+I +G +FH G++ RN +N+LD ++V V L +
Sbjct: 108 DSSEINDNLEVAEYVFLAVFTMEAVLKIIAYGFLFHPGAYLRNGWNILDFVIVVVGLATI 167
Query: 2647 VLRTDAMSXXXXXXXXXXXXXXXAINRAKG---LKHVVQCVIVAVKTIGNIMLVTFMLQF 2817
+++ S + G L+ V+ +I A+ + +I L+ +
Sbjct: 168 LVKATLSSGSFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKALIPLFHIALLVVFVVI 227
Query: 2818 MFAIIGVQLFKGTFF-LCNDLSKMTEAECRGEYIHYEDGDPTKPVSK------KRVWSNN 2976
++AIIGV+LF G C D +T AE E G K + W
Sbjct: 228 IYAIIGVELFMGRLHKTCYD--NVTGAESFEEPHPCSSGSSGFQCDKAAGQVCEGGWKGP 285
Query: 2977 DF---NFDNVGDAMISLFVVSTFEGWPQLLY 3060
+ NFDN+G A +++F T EGW +LY
Sbjct: 286 NHGITNFDNIGLACMTVFQCITLEGWTDVLY 316
Score = 90.1 bits (222), Expect = 6e-16
Identities = 75/306 (24%), Positives = 134/306 (43%), Gaps = 18/306 (5%)
Frame = +1
Query: 250 IVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIV 429
+V + FE+LI I N + L + Q Y Q+ +L+ F VF +EC+LK++
Sbjct: 1165 VVTSQAFEYLIFAFIVCNTVVLMM-QYY--QEPKLYTRVLDGFNIGFTAVFLLECILKLI 1221
Query: 430 AMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSI-QGFDVKALRAFRVLRPLRLVS 606
A F P Y + WN+ DFIIVV ++ ++++S Q F R FR LR ++L++
Sbjct: 1222 A----FKPKNYFTDRWNLFDFIIVVGSIIDITMNEVSSEQMFAFGFFRLFRALRLVKLLN 1277
Query: 607 GVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQK 786
++ +L +++ L ++ALL++ + IYA+IG+++F G++A
Sbjct: 1278 QGSGIKTLLWTFIKSFQALPYVALLIVMMFFIYAVIGMQMF-------------GRIAIN 1324
Query: 787 DPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQC 966
SD+ N NN NF F +++ +F+
Sbjct: 1325 ------------------SDTAINR---------------NN---NFQTFPQSLMVLFRS 1348
Query: 967 VSLEGWTDVMYWV-----------------NDAVGREWPWIYFVTLVILGSFFVLNLVLG 1095
+ E W +M + G ++ + YFV+ + SF ++NL +
Sbjct: 1349 ATGENWQQIMLACTHRDDVKCDQNADPQEPSGLCGSDFAYFYFVSFYSICSFLIINLFVA 1408
Query: 1096 VLSGEF 1113
V+ F
Sbjct: 1409 VIMDNF 1414
Score = 89.4 bits (220), Expect = 9e-16
Identities = 75/298 (25%), Positives = 126/298 (42%), Gaps = 46/298 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACKH---YPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ F+ +I + I N +LA S D L+V +F VF EAVLKI+A
Sbjct: 81 KPFDVMILITIFANCAALAAFEPLPEKDSSEINDNLEVAEYVFLAVFTMEAVLKIIAYGF 140
Query: 3511 -LNPKNYISDRWNVFD-LLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSR 3684
+P Y+ + WN+ D ++VVVG + L+ G + R FRV+R ++L+S
Sbjct: 141 LFHPGAYLRNGWNILDFVIVVVGLATILVKATLSSGS---FDVKALRAFRVLRPLRLVSG 197
Query: 3685 GEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF----GKVALDDSTSI----- 3837
++ +L + +K+ L ++ALL+V + IYA+IG++ F K D+ T
Sbjct: 198 VPSLQVVLNSIIKALIPLFHIALLVVFVVIIYAIIGVELFMGRLHKTCYDNVTGAESFEE 257
Query: 3838 -----------------------------HRNNNFHSFPAAILVLFRSATGEAWQDIMLS 3930
H NF + A + +F+ T E W D++
Sbjct: 258 PHPCSSGSSGFQCDKAAGQVCEGGWKGPNHGITNFDNIGLACMTVFQCITLEGWTDVLYW 317
Query: 3931 CSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
+D GN++ + YF++ + SF V+NL + V+ F
Sbjct: 318 IND---------------------AVGNSWPWVYFVTLIIWGSFFVLNLVLGVLSGEF 354
Score = 64.7 bits (156), Expect = 2e-08
Identities = 53/250 (21%), Positives = 95/250 (37%), Gaps = 13/250 (5%)
Frame = +1
Query: 1405 LVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLG 1584
+V SQ F + ++Y + + N+ F +F +E +LK+ +
Sbjct: 1165 VVTSQAFEYLIFAFIVCNTVVLMMQYYQEPKLYTRVLDGFNIGFTAVFLLECILKLIAFK 1224
Query: 1585 FTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXX 1764
Y T ++N FD +V+ SI++ + + R R LR+ K+ +
Sbjct: 1225 PKNYFTDRWNLFDFIIVVGSIIDITMNEVSSEQMFAFGFFRLFRALRLVKLLNQGSGIKT 1284
Query: 1765 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLT 1944
GMQ+FG + NF TF Q+L+
Sbjct: 1285 LLWTFIKSFQALPYVALLIVMMFFIYAVIGMQMFGRIAINSDTAINRNNNFQTFPQSLMV 1344
Query: 1945 VFQILTGEDWNTVMY-----------HGIESFGGVGTLGVIVCIYYIVLF--ICGNYILL 2085
+F+ TGE+W +M + G G +Y V F IC +++++
Sbjct: 1345 LFRSATGENWQQIMLACTHRDDVKCDQNADPQEPSGLCGSDFAYFYFVSFYSIC-SFLII 1403
Query: 2086 NVFLAIAVDN 2115
N+F+A+ +DN
Sbjct: 1404 NLFVAVIMDN 1413
Score = 42.4 bits (98), Expect = 0.13
Identities = 51/231 (22%), Positives = 82/231 (35%), Gaps = 38/231 (16%)
Frame = +1
Query: 1531 FFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVS 1698
FF +F+ E+L+K S G ++ S FN D VV S++ L V
Sbjct: 889 FFTSVFTFEILVKFISYGLILHKGSFCRSAFNLLDLLVVSVSVISISLRTSQFSV---VR 945
Query: 1699 VLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF 1878
+LR R+LR + G+Q+F G F
Sbjct: 946 ILRVLRVLRPLRAINRAKGLKHVVQSVFVAVKTIGNIKLVTMLFQFLFAVIGVQLFKGTF 1005
Query: 1879 ----------------NF---------NP-----QQPKPRANFDTFVQALLTVFQILTGE 1968
N+ NP + + NFD A+LT+F ++T E
Sbjct: 1006 FSCNDEKILTAEECQGNYIDFKGPGLSNPVVKEREWRRHDFNFDNVGNAMLTLFTVMTFE 1065
Query: 1969 DWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
W ++ + I+S G V IYYI+ I + ++N+F+ +
Sbjct: 1066 GWPGILENSIDSTEVDKGPNQNNRPWVAIYYIIYIIIIAFFMVNIFVGFVI 1116
>gi|7508712|pir||T16779 hypothetical protein unc-2 - Caenorhabditis
elegans
Length = 1529
Score = 969 bits (2504), Expect = 0.0
Identities = 568/1381 (41%), Positives = 764/1381 (55%), Gaps = 71/1381 (5%)
Frame = +1
Query: 652 MIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQL--AQKDPTPCGTDTEGSA 825
M PLL I LLVLF I+I+AIIGLE + G HS C + G++ + P PC T
Sbjct: 1 MAPLLQIGLLVLFAIIIFAIIGLEFYSGAFHSACYNER-GEIENVSERPMPCTNKT---- 55
Query: 826 FKCQPSDSLTNMGVRWECSSNTT-----WPGPNNGITNFDNFGLAMLTVFQCVSLEGWTD 990
+ MGV + C T W GPN GIT+FDN G AM+TVFQC+++EGWT
Sbjct: 56 ---------SPMGV-YNCDVKGTTCLQKWIGPNYGITSFDNIGFAMITVFQCITMEGWTT 105
Query: 991 VMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREK 1170
VMY+ ND++G + W YF+ L++LGSFF+LNLVLGVLSGEF+KERE+ R F K R +
Sbjct: 106 VMYYTNDSLGSTYNWAYFIPLIVLGSFFMLNLVLGVLSGEFAKERERVENRREFLKLRRQ 165
Query: 1171 QQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKW-- 1344
QQ+E +L GYL+WI AE++ + E+E A ++
Sbjct: 166 QQIERELNGYLEWILTAEEVILKEDRTTEEEKAAIMEARRRAANKKLKQASKQQSTETEE 225
Query: 1345 ----------------AARMKR-----LEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXX 1461
A R KR + K +VK+Q FYW
Sbjct: 226 DFEEDEDEMEEEYVDEAERKKRGCCHSVGKFIKQLRIQIRIMVKTQIFYWSVITLVFLNT 285
Query: 1462 XXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVIS 1641
SEHYGQ +W F A F+ +F +EMLLK++++G TY S+FNRFDC V++
Sbjct: 286 CCVASEHYGQPQWFTDFLKYAEFVFLGIFVVEMLLKLFAMGSRTYFASKFNRFDCVVIVG 345
Query: 1642 SILEFVL--VYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXX 1815
S E + VY G+SV+R+ RLLRIFK+T YW
Sbjct: 346 SAAEVIWAEVYGG---SFGISVMRALRLLRIFKLTSYWVSLRNLVRSLMNSMRSIISLLF 402
Query: 1816 XXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQ-------------- 1953
GMQ+FGG+FNF P +FDTF AL+TVFQ
Sbjct: 403 LLFLFILIFALLGMQLFGGRFNFPTMHPY--THFDTFPVALITVFQVSKNVINCKCINVL 460
Query: 1954 -ILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADAD 2130
ILTGEDWN VMY IES GG+ + G IY+IVL + GNY LLNVFLAIAVDNLA+A
Sbjct: 461 KILTGEDWNEVMYLAIESQGGIYSGGWPYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQ 520
Query: 2131 SLTNAXXXXXXXXXXXXXXXXXX---------XXXXXXXXXXXXXXXXXXMTSARPRRMS 2283
LT A M
Sbjct: 521 ELTAAEEADEKANEIEEESEELDEQYQEGDHCTIDMEGKTAGDMCAVARAMDDLDEECEE 580
Query: 2284 EVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPL 2463
E KP+ SS+F LS TN FRV + +V YF V+ I +SS LAAEDP+
Sbjct: 581 EESPFGGPKPMVPYSSMFFLSPTNPFRVLIHSIVCTKYFEMMVMTVICLSSVSLAAEDPV 640
Query: 2464 QANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTS 2643
+ RN +L Y DY FT VF E+ LK+I G++ H GS+CR+ +N+LD +VV +L +
Sbjct: 641 DEENPRNKVLQYMDYCFTGVFACEMLLKLIDQGILLHPGSYCRDFWNILDGIVVTCALFA 700
Query: 2644 FVLRTDAMSXXXXXXXXXXXXXXXA------INRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
F S I R LK V CV+ ++K + NI++V F
Sbjct: 701 FGFAGTEGSAGKNLNTIKSLRVLRVLRPLKTIKRIPKLKAVFDCVVNSLKNVFNILIVYF 760
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYED-GDPTKPVSKKRVWSNNDF 2982
+ QF+FA+I VQLF G FF C D ++ C G++ Y++ DP P ++R W F
Sbjct: 761 LFQFIFAVIAVQLFNGKFFFCTDKNRKFANTCHGQFFVYDNQNDP--PRVEQREWRLRPF 818
Query: 2983 NFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXX 3162
N+DN +AM++LFVV+T EGWP + ++D+ ED+GP R VAL
Sbjct: 819 NYDNTINAMLTLFVVTTGEGWPGIRQNSMDTTFEDQGPSPFFRVEVALFYVMFFIVFPFF 878
Query: 3163 XXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIP--RNRLQYRVWW 3336
+I+TFQ +GE E +LDKNQ++CI+FAL A+P ++P +N +YR+W
Sbjct: 879 FVNIFVALIIITFQEQGEAELSEGDLDKNQKQCIDFALNARPRSLFMPEDKNSTKYRIWR 938
Query: 3337 FVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALN 3516
VTS FEY I +I NT+ L K+Y + +E+ L +FN T VF E++LKI+A
Sbjct: 939 LVTSPPFEYFIMTMICCNTLILMMKYYNNPLFYEEILRLFNTALTAVFTVESILKILAFG 998
Query: 3517 PKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGI 3696
+NY D WN FD + VVGS D + G + +S+ F RLFR RL++LL +G I
Sbjct: 999 VRNYFRDGWNRFDFVTVVGSITDALVTEF---GGHFVSLGFLRLFRAARLIRLLQQGYTI 1055
Query: 3697 RTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAI 3876
R LLWTF++SF+ALPYV LLI +LFFIYA++GMQ FG + L+ +T I+R+NNF SF A+
Sbjct: 1056 RILLWTFVQSFKALPYVCLLIGMLFFIYAIVGMQVFGNIWLNAATEINRHNNFQSFFNAV 1115
Query: 3877 LVLFRSATGEAWQDIMLSCSDRED-VRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFML 4053
++LFR ATGE WQDIM++ +D R ++ KG CG+N +Y YF SF L
Sbjct: 1116 ILLFRCATGEGWQDIMMAAVQGKDCARAGSAEINFEKG----QTCGSNVSYAYFTSFVFL 1171
Query: 4054 CSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLR 4233
SFL++NLFVAVIMDNFDYLTRD SILGPHHL+EF+R+W++YDP A GRI + ++ +LR
Sbjct: 1172 SSFLMLNLFVAVIMDNFDYLTRDSSILGPHHLDEFIRVWADYDPAATGRIHYSEMYEMLR 1231
Query: 4234 KISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNL--KIYTEGNIDE 4407
++PP+GFGK CP+RLA K L+ MNMP+ DGTV F TLFAL+R +L K+ +DE
Sbjct: 1232 IMAPPVGFGKKCPYRLAYKHLIRMNMPVAEDGTVHFTTTLFALIRESLSIKMRPVEEMDE 1291
Query: 4408 ANEQLRSAIKRIWK-RTHKDLLDEVVPPAGK--EDDVTVGKFYATFLIQDYFRRFKKRKE 4578
A+E+LR +K+IW + K+++D VVPP + +TVGK YA LI + +R K E
Sbjct: 1292 ADEELRLTLKKIWPLKAKKNMVDLVVPPNHELCFQKLTVGKIYAGLLILENYRARKSGTE 1351
Query: 4579 M 4581
+
Sbjct: 1352 I 1352
Score = 113 bits (282), Expect = 6e-23
Identities = 90/336 (26%), Positives = 156/336 (45%), Gaps = 16/336 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP R L SIV K FE +++ +IC + ++LA P + + +N +L+ ++Y F VF
Sbjct: 604 NPFRVLIHSIVCTKYFEMMVMTVICLSSVSLAAEDP--VDEENPRNKVLQYMDYCFTGVF 661
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGF------DVKA 564
E +LK++ G + HP +Y R+ WNILD I+V L + +G +K+
Sbjct: 662 ACEMLLKLIDQGILLHPGSYCRDFWNILDGIVVTCALFA--FGFAGTEGSAGKNLNTIKS 719
Query: 565 LRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLH 744
LR RVLRPL+ + +P L+ V + ++ ++ + +I ++ I+A+I ++LF GK
Sbjct: 720 LRVLRVLRPLKTIKRIPKLKAVFDCVVNSLKNVFNILIVYFLFQFIFAVIAVQLFNGKFF 779
Query: 745 STCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVR-WECSSNTTWPGPNNGIT 921
C D +K C G F + + R W
Sbjct: 780 -FCTDK-----NRKFANTC----HGQFFVYDNQNDPPRVEQREWRLRP-----------F 818
Query: 922 NFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREW---PW------IYFVTLVILGSFF 1074
N+DN AMLT+F + EGW + D + P+ +++V I+ FF
Sbjct: 819 NYDNTINAMLTLFVVTTGEGWPGIRQNSMDTTFEDQGPSPFFRVEVALFYVMFFIVFPFF 878
Query: 1075 VLNLVLGVLSGEFSKEREKARARGLFQKFREKQQLE 1182
+N+ + ++ F ++ E + G K +KQ ++
Sbjct: 879 FVNIFVALIIITFQEQGEAELSEGDLDK-NQKQCID 913
Score = 95.1 bits (235), Expect = 2e-17
Identities = 80/345 (23%), Positives = 155/345 (44%), Gaps = 24/345 (6%)
Frame = +1
Query: 229 IRKLCISI---VEWKPFEFLILFMICAN-CIALAIYQPYPAQDSDYKNTLLETIEYVFIV 396
I++L I I V+ + F + ++ ++ N C + + P +D+ L+ E+VF+
Sbjct: 257 IKQLRIQIRIMVKTQIFYWSVITLVFLNTCCVASEHYGQPQWFTDF----LKYAEFVFLG 312
Query: 397 VFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAF 576
+F +E +LK+ AMG Y + +N D +++V I +++ F + +RA
Sbjct: 313 IFVVEMLLKLFAMG----SRTYFASKFNRFDCVVIVGSAAEVIWAEVYGGSFGISVMRAL 368
Query: 577 RVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI 756
R+LR +L S SL+ ++ +++ +M ++ + L+ ILI+A++G++LF G+ + +
Sbjct: 369 RLLRIFKLTSYWVSLRNLVRSLMNSMRSIISLLFLLFLFILIFALLGMQLFGGRFNFPTM 428
Query: 757 DPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNF 936
P T +FD F
Sbjct: 429 HPYT---------------------------------------------------HFDTF 437
Query: 937 GLAMLTVFQ---------CVSL------EGWTDVMYWVNDAVG----REWPW-IYFVTLV 1056
+A++TVFQ C+++ E W +VMY ++ G WP+ IYF+ LV
Sbjct: 438 PVALITVFQVSKNVINCKCINVLKILTGEDWNEVMYLAIESQGGIYSGGWPYSIYFIVLV 497
Query: 1057 ILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDL 1191
+ G++ +LN+ L + + +E A +K E ++ E+L
Sbjct: 498 LFGNYTLLNVFLAIAVDNLANAQELTAAEEADEKANEIEEESEEL 542
Score = 86.7 bits (213), Expect = 6e-15
Identities = 73/307 (23%), Positives = 124/307 (39%), Gaps = 19/307 (6%)
Frame = +1
Query: 250 IVEWKPFEFLILFMICANCIALAI-YQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKI 426
+V PFE+ I+ MIC N + L + Y P + +L VFT+E +LKI
Sbjct: 939 LVTSPPFEYFIMTMICCNTLILMMKYYNNPL----FYEEILRLFNTALTAVFTVESILKI 994
Query: 427 VAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVS 606
+A G Y R+ WN DF+ VV + ++++ + LR FR R +RL+
Sbjct: 995 LAFGVR----NYFRDGWNRFDFVTVVGSITDALVTEFGGHFVSLGFLRLFRAARLIRLLQ 1050
Query: 607 GVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQK 786
+++++L +++ L ++ LL+ + IYAI+G+++F
Sbjct: 1051 QGYTIRILLWTFVQSFKALPYVCLLIGMLFFIYAIVGMQVF------------------- 1091
Query: 787 DPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQC 966
G W + T +N +F N A++ +F+C
Sbjct: 1092 -------------------------GNIW--LNAATEINRHNNFQSFFN---AVILLFRC 1121
Query: 967 VSLEGWTDVM------------------YWVNDAVGREWPWIYFVTLVILGSFFVLNLVL 1092
+ EGW D+M + G + YF + V L SF +LNL +
Sbjct: 1122 ATGEGWQDIMMAAVQGKDCARAGSAEINFEKGQTCGSNVSYAYFTSFVFLSSFLMLNLFV 1181
Query: 1093 GVLSGEF 1113
V+ F
Sbjct: 1182 AVIMDNF 1188
>gi|736714|dbj|BAA07283.1| L-type voltage-dependent calcium channel
alpha 1 subunit [Rattus norvegicus]
Length = 1668
Score = 967 bits (2499), Expect = 0.0
Identities = 474/744 (63%), Positives = 578/744 (76%), Gaps = 1/744 (0%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPRR+SE+ + PIP+ S+ FILS TN RV C+ ++NH FTN +L I++SSA L
Sbjct: 903 RPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAAL 962
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP++++S RN IL YFDY FT++FTVEI LK+ FG HKG+FCRN FNLLD+LVV
Sbjct: 963 AAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVV 1022
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
VSL SF +++ A+S AINRAKGLKHVVQCV VA++TIGNIM+VT
Sbjct: 1023 GVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTT 1082
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG F+ C D +K ECRG +I Y+DGD PV ++R+W N+DFN
Sbjct: 1083 LLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFN 1142
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP LLY AIDSN E+ GP++N R +++
Sbjct: 1143 FDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENVGPVYNYRVEISIFFIIYIIIVAFFM 1202
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N QY+ W+ V
Sbjct: 1203 MNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVN 1262
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S+ F D +D+ N++FTGVF E VLK++A PK
Sbjct: 1263 SSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKG 1322
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKL-NPGGTNLISINFFRLFRVMRLVKLLSRGEGIRT 3702
Y SD WN FD L+V+GS ID+ + N +N ISI FFRLFRVMRLVKLLSRGEGIRT
Sbjct: 1323 YFSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFFRLFRVMRLVKLLSRGEGIRT 1382
Query: 3703 LLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILV 3882
LLWTF+KSFQALPYVALLI +LFFIYAVIGMQ FGKVA+ D+ I+RNNNF +FP A+L+
Sbjct: 1383 LLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLL 1442
Query: 3883 LFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSF 4062
LFR ATGEAWQ+IML+C + CDP SD Y+ G E CG+NFA YFISF+MLC+F
Sbjct: 1443 LFRCATGEAWQEIMLACLPGK--LCDPDSD-YNPG--EEYTCGSNFAIVYFISFYMLCAF 1497
Query: 4063 LVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKIS 4242
L+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+WSEYDP+AKGRIKHLDVVTLLR+I
Sbjct: 1498 LIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQ 1557
Query: 4243 PPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNIDEANEQL 4422
PPLGFGKLCPHR+ACKRLV+MNMPLNSDGTV FNATLFALVRT LKI TEGN+++ANE+L
Sbjct: 1558 PPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEEL 1617
Query: 4423 RSAIKRIWKRTHKDLLDEVVPPAG 4494
R+ IK+IWK+T LLD+VVPPAG
Sbjct: 1618 RAVIKKIWKKTSMKLLDQVVPPAG 1641
Score = 473 bits (1216), Expect = e-131
Identities = 232/360 (64%), Positives = 281/360 (77%), Gaps = 12/360 (3%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
NNPIR+ CISIV+WKPF+ IL I ANC+ALAIY P+P DS+ N LE +EY F+++
Sbjct: 112 NNPIRRACISIVDWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLII 171
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQ----------- 546
FT+E LKI+A G + HP+A +RN WN+LDF+IV++GL S IL +++ +
Sbjct: 172 FTVETFLKIIASGLLLHPNASVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKS 231
Query: 547 -GFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLE 723
GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+I++AM+PLLHIALLVLFVI+IYAIIGLE
Sbjct: 232 GGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLE 291
Query: 724 LFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPG 903
LF GK+H TC + +A++DP PC G+ +C + + EC S W G
Sbjct: 292 LFIGKMHKTCFFADSDIVAEEDPAPCAFS--GNGRQCAANGT--------ECRSG--WVG 339
Query: 904 PNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLN 1083
PN GITNFDNF AMLTVFQC+++EGWTDV+YWVNDA+G EWPW+YFV+L+ILGSFFVLN
Sbjct: 340 PNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLN 399
Query: 1084 LVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDE 1263
LVLGVLSGEFSKEREKA+ARG FQK REKQQLEEDLKGYLDWITQAEDI+P NE+E +E
Sbjct: 400 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEE 459
Score = 259 bits (663), Expect = 4e-67
Identities = 136/263 (51%), Positives = 159/263 (59%)
Frame = +1
Query: 1357 KRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFF 1536
+R + N VKS TFYW +SEHY Q +WL Q +AN
Sbjct: 562 RRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVL 621
Query: 1537 VILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSAR 1716
+ LF+ EML+KMYSLG Y S FNRFDCFVV I E +LV +LM PLGVSV R R
Sbjct: 622 LALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELELMSPLGVSVFRCVR 681
Query: 1717 LLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQ 1896
LLRIFKVT++WT GMQ+FGGKFNF+ Q
Sbjct: 682 LLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQ 741
Query: 1897 PKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNY 2076
K R+ FD F QALLTVFQILTGEDWN VMY GI ++GG + G+IVCIY+I+LFICGNY
Sbjct: 742 TK-RSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNY 800
Query: 2077 ILLNVFLAIAVDNLADADSLTNA 2145
ILL +FLAIAVDNLADA+SL A
Sbjct: 801 ILLKLFLAIAVDNLADAESLNTA 823
Score = 128 bits (322), Expect = 1e-27
Identities = 92/312 (29%), Positives = 152/312 (48%), Gaps = 9/312 (2%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR C ++ F LIL I + ALA P + ++NT+L +Y F +F
Sbjct: 932 NPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPI--RSHSFRNTILGYFDYAFTAIF 989
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
T+E +LK+ G H A+ RN +N+LD ++V + LVS + +I VK LR RV
Sbjct: 990 TVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAIS--VVKILRVLRV 1047
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLR ++ L+ V+ + A+ + +I ++ + ++A IG++LF GK + C D
Sbjct: 1048 LRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFY-RCTDE 1106
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
A+ +P C F + + VR N+ + NFDN
Sbjct: 1107 -----AKSNPEEC-----RGLFILYKDGDVDSPVVRERIWQNSDF--------NFDNVLS 1148
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDAVG---------REWPWIYFVTLVILGSFFVLNLVLG 1095
AM+ +F + EGW ++Y D+ G R I+F+ +I+ +FF++N+ +G
Sbjct: 1149 AMMALFTVSTFEGWPALLYKAIDSNGENVGPVYNYRVEISIFFIIYIIIVAFFMMNIFVG 1208
Query: 1096 VLSGEFSKEREK 1131
+ F ++ EK
Sbjct: 1209 FVIVTFQEQGEK 1220
Score = 100 bits (249), Expect = 4e-19
Identities = 68/270 (25%), Positives = 130/270 (47%)
Frame = +1
Query: 3292 RRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFT 3471
RR+ NR + R V S F +++ +++ +NT++++ +HY D+ N +
Sbjct: 565 RRWNRFNRRRCRA--AVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLL 622
Query: 3472 GVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLF 3651
+F E ++K+ +L + Y +N FD VV G + +L + + ++ FR
Sbjct: 623 ALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEL--MSPLGVSVFRCV 680
Query: 3652 RVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDST 3831
R++R+ K+ + L+ + + S +++ + LL+ L I++++GMQ FG D T
Sbjct: 681 RLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDET 740
Query: 3832 SIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCG 4011
R + F +FP A+L +F+ TGE W +M GG + S
Sbjct: 741 QTKR-STFDNFPQALLTVFQILTGEDWNAVM-------------YDGIMAYGGPSSS--- 783
Query: 4012 NNFAYPYFISFFMLCSFLVINLFVAVIMDN 4101
YFI F+ +++++ LF+A+ +DN
Sbjct: 784 GMIVCIYFIILFICGNYILLKLFLAIAVDN 813
Score = 99.0 bits (245), Expect = 1e-18
Identities = 76/317 (23%), Positives = 135/317 (41%), Gaps = 20/317 (6%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP + +V PFE+++ +I N + LA+ Q Y + S N ++ + VF VF
Sbjct: 1251 NPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAM-QHY--EQSKMFNDAMDILNMVFTGVF 1307
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMS----IQGFDVKALR 570
T+E VLK++A F P Y +AWN D +IV+ ++ LS+ + R
Sbjct: 1308 TVEMVLKVIA----FKPKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFFR 1363
Query: 571 AFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHST 750
FRV+R ++L+S ++ +L +++ L ++ALL+ + IYA+IG+++F
Sbjct: 1364 LFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMF------- 1416
Query: 751 CIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFD 930
G++A +D N NF
Sbjct: 1417 ------GKVAMRDNNQI------------------------------------NRNNNFQ 1434
Query: 931 NFGLAMLTVFQCVSLEGWTDVMY----------------WVNDAVGREWPWIYFVTLVIL 1062
F A+L +F+C + E W ++M G + +YF++ +L
Sbjct: 1435 TFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPDSDYNPGEEYTCGSNFAIVYFISFYML 1494
Query: 1063 GSFFVLNLVLGVLSGEF 1113
+F ++NL + V+ F
Sbjct: 1495 CAFLIINLFVAVIMDNF 1511
Score = 91.7 bits (226), Expect = 2e-16
Identities = 146/706 (20%), Positives = 255/706 (35%), Gaps = 80/706 (11%)
Frame = +1
Query: 232 RKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIE 411
R+ C + V+ F +L++ ++ N + ++ D+ + + V + +FT E
Sbjct: 572 RRRCRAAVKSVTFYWLVIVLVFLNTLTISSEH---YNQPDWLTQIQDIANKVLLALFTCE 628
Query: 412 CVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG-FDVKALRAFRVLR 588
++K+ ++G AY + +N D +V G+ TIL ++ + V R R+LR
Sbjct: 629 MLVKMYSLGLQ----AYFVSLFNRFDCFVVCGGITETILVELELMSPLGVSVFRCVRLLR 684
Query: 589 PLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPAT 768
++ SL ++ ++L +M + + LL+ I+I++++
Sbjct: 685 IFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLL------------------ 726
Query: 769 GQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAM 948
G G F + + + FDNF A+
Sbjct: 727 -----------GMQLFGGKFNFDETQTKRS---------------------TFDNFPQAL 754
Query: 949 LTVFQCVSLEGWTDVMYWVNDAVGREWP-----WIYFVTLVILGSFFVLNLVLGVLSGEF 1113
LTVFQ ++ E W VMY A G IYF+ L I G++ +L L L +
Sbjct: 755 LTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLKLFLAIAVDNL 814
Query: 1114 S---------------KEREK-ARARGLFQKFREKQQLEE----DLKGYL-DWITQAEDI 1230
+ KER+K AR L K K ++ + D K + D+ +AED
Sbjct: 815 ADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYQEEAEDK 874
Query: 1231 EPV----------NEDEQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNX 1380
+P E+E+EDEP P + L K N
Sbjct: 875 DPYPPCDVPVGEEEEEEEEDEPEV-PAGPRPRRISELNMKEKIAPIPEGSAFFILSKTN- 932
Query: 1381 XXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSE-----HYGQSEWLDHFQTMANLFFVIL 1545
L+ F +E H ++ L +F + F +
Sbjct: 933 PIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYF----DYAFTAI 988
Query: 1546 FSMEMLLKMYSLGF----TTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSA 1713
F++E+LLKM + G + + FN D VV S++ F + + V +LR
Sbjct: 989 FTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISV---VKILRVL 1045
Query: 1714 RLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF----- 1878
R+LR + G+Q+F GKF
Sbjct: 1046 RVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTD 1105
Query: 1879 --NFNPQQ---------------PKPRA--------NFDTFVQALLTVFQILTGEDWNTV 1983
NP++ P R NFD + A++ +F + T E W +
Sbjct: 1106 EAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPAL 1165
Query: 1984 MYHGI----ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+Y I E+ G V V + I++I+ I + ++N+F+ +
Sbjct: 1166 LYKAIDSNGENVGPVYNYRVEISIFFIIYIIIVAFFMMNIFVGFVI 1211
Score = 85.9 bits (211), Expect = 1e-14
Identities = 79/275 (28%), Positives = 120/275 (42%), Gaps = 24/275 (8%)
Frame = +1
Query: 2323 ASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPL---QANSTRNMIL 2493
A +LF LS N R C +V+ F +L I + LA P +NST N L
Sbjct: 103 ARALFCLSLNNPIRRACISIVDWKPFDIFILLAIFANCVALAIYIPFPEDDSNST-NHNL 161
Query: 2494 NYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL-----RT 2658
+Y F +FTVE LK+I GL+ H + RN +NLLD ++V V L S +L T
Sbjct: 162 EKVEYAFLIIFTVETFLKIIASGLLLHPNASVRNGWNLLDFVIVIVGLFSVILEQLTKET 221
Query: 2659 DAMSXXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFML 2811
+ + A ++ L+ V+ +I A+ + +I L+ +
Sbjct: 222 EGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFV 281
Query: 2812 QFMFAIIGVQLF-----KGTFFLCNDL-SKMTEAECRGEYIHYEDGDPTKPVSKKRVWSN 2973
++AIIG++LF K FF +D+ ++ A C + V N
Sbjct: 282 IIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCAANGTECRSGWVGPN 341
Query: 2974 NDF-NFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
NFDN AM+++F T EGW +LY D+
Sbjct: 342 GGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDA 376
Score = 79.7 bits (195), Expect = 7e-13
Identities = 80/352 (22%), Positives = 139/352 (38%), Gaps = 53/352 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ F+ I L I N V+LA +P S L+ F +F E LKI+A
Sbjct: 126 KPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIASGL 185
Query: 3511 -LNPKNYISDRWNVFDLLVVVGSFIDITYGKL---------NPGGTNLISINFFRLFRVM 3660
L+P + + WN+ D ++V+ + +L + G + + R FRV+
Sbjct: 186 LLHPNASVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVL 245
Query: 3661 RLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF------------ 3804
R ++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F
Sbjct: 246 RPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFAD 305
Query: 3805 -----------------GKVALDDSTSIHRN--------NNFHSFPAAILVLFRSATGEA 3909
G+ + T NF +F A+L +F+ T E
Sbjct: 306 SDIVAEEDPAPCAFSGNGRQCAANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEG 365
Query: 3910 WQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAV 4089
W D++ +D G + + YF+S +L SF V+NL + V
Sbjct: 366 WTDVLYWVND---------------------AIGWEWPWVYFVSLIILGSFFVLNLVLGV 404
Query: 4090 IMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
+ F G + +R + + D KG +LD +T I P
Sbjct: 405 LSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 450
Score = 74.3 bits (181), Expect = 3e-11
Identities = 53/230 (23%), Positives = 98/230 (42%), Gaps = 17/230 (7%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HY QS+ + + N+ F +F++EM+LK+ + Y + +N FD +VI SI++
Sbjct: 1284 QHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDV 1343
Query: 1657 VLVYFDLMKP---LGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXX 1827
L D + + ++ R R++R+ K+
Sbjct: 1344 ALSEADNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAM 1403
Query: 1828 XXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVM------- 1986
GMQ+FG + Q NF TF QA+L +F+ TGE W +M
Sbjct: 1404 LFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGK 1463
Query: 1987 -------YHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDN 2115
Y+ E + + +Y+I ++ ++++N+F+A+ +DN
Sbjct: 1464 LCDPDSDYNPGEEYTCGSNFAI---VYFISFYMLCAFLIINLFVAVIMDN 1510
Score = 45.4 bits (106), Expect = 0.016
Identities = 23/64 (35%), Positives = 36/64 (55%)
Frame = +1
Query: 1912 NFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNV 2091
NFD F A+LTVFQ +T E W V+Y ++ G +Y++ L I G++ +LN+
Sbjct: 346 NFDNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWP-----WVYFVSLIILGSFFVLNL 400
Query: 2092 FLAI 2103
L +
Sbjct: 401 VLGV 404
>gi|1698403|gb|AAB37235.1| dihydropyridine receptor alpha 1 subunit
Length = 1871
Score = 964 bits (2493), Expect = 0.0
Identities = 509/877 (58%), Positives = 619/877 (70%), Gaps = 30/877 (3%)
Frame = +1
Query: 2260 SARPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSA 2439
S RPR ++E+ PIP+ASS FI S TN RV C+ +VN ++FTN +L IL+SSA
Sbjct: 755 SPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSA 814
Query: 2440 MLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDIL 2619
LAAEDP++A+S RN IL +FD FTSVFTVEI LK+ +G HKGSFCRN FN+LD+L
Sbjct: 815 ALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLL 874
Query: 2620 VVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLV 2799
VVAVSL S L + A+S AINRAKGLK C+ VA+ TIGNI+LV
Sbjct: 875 VVAVSLISMGLESSAISVVKILRVLRVLRPLRAINRAKGLK----CMFVAISTIGNIVLV 930
Query: 2800 TFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNND 2979
T +LQFMFA IGVQLFKG FF C DLSKMTE ECRG Y Y+DGDP + + R W ++D
Sbjct: 931 TTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHREWVHSD 990
Query: 2980 FNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXX 3159
F+FDNV AM+SLF VSTFEGWPQLLY AIDSN ED GPI+N+R +A+
Sbjct: 991 FHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIILIAF 1050
Query: 3160 XXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWF 3339
GFVIVTFQ +GE EY+NCELDKNQR+C+++ALKA+P R YIP+N QY+VW+
Sbjct: 1051 FMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQVWYI 1110
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
VTS FEY++F +I++NT+ L +HY S D+ N+ FT +F E +LK++A
Sbjct: 1111 VTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMAFKA 1170
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITY--------------------GKLNPGGTNLISINF 3639
+ Y + WNVFD L+V+GS ID+ G ++P + IS F
Sbjct: 1171 RGYFGNPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARISSAF 1230
Query: 3640 FRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVAL 3819
FRLFRVMRL+KLLSR EG+RTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL
Sbjct: 1231 FRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIAL 1290
Query: 3820 DDSTSIHRNNNFHSFPAAILVLFRSA--TGEAWQDIMLSCSDREDVRCDPMSDDYHKGGL 3993
D T I+RNNNF +FP A+L+LFR A TGEAWQ+I+L+CS + CDP SD Y G
Sbjct: 1291 VDGTQINRNNNFQTFPQAVLLLFRHACATGEAWQEILLACSYGK--LCDPESD-YAPG-- 1345
Query: 3994 NESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWS 4173
E CG NFAY YFISF+MLC+FLVINLFVAVIMDNFDYLTRDWSILGPHHL+EF +W+
Sbjct: 1346 EEYTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWA 1405
Query: 4174 EYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATL 4353
EYDP+AKGRIKHLDVVTLLR+I PPLGFGK CPHR+ACKRLV MNMPLNSDGTV FNATL
Sbjct: 1406 EYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATL 1465
Query: 4354 FALVRTNLKIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYAT 4533
FALV T LKI TEGN ++ANE+LR+ IK+IWKRT LLD+V+PP G +D+VTVGKFYAT
Sbjct: 1466 FALVGTALKIKTEGNFEQANEELRAIIKKIWKRTSMKLLDQVMPPIG-DDEVTVGKFYAT 1524
Query: 4534 FLIQDYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTL-HEIGPELKRAISGNLETDFN 4710
FLIQ+ FR+F KR+E E G P + + +QAGLRT+ E PE+ R +SG+L +
Sbjct: 1525 FLIQEDFRKFMKRQE-EYYGYRPKK--DIVQIQAGLRTIEEEAAPEICRTVSGDLAAEEE 1581
Query: 4711 FDE-------PEPQHRRPHSLFNNLVHRLSGAGSKSP 4800
+ E RR LF + + L S P
Sbjct: 1582 LERAMVEAAMEEGIFRRTGGLFGQVDNFLERTNSLPP 1618
Score = 657 bits (1696), Expect = 0.0
Identities = 343/659 (52%), Positives = 436/659 (66%), Gaps = 18/659 (2%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+RK CISIVEWKPFE +IL I ANC+ALA+Y P P D++ N LE +EY F++VF
Sbjct: 38 NPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVF 97
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSI------------Q 546
+IE +KI+A GF+FH AYLR+ WN+LDF IV +G+ + IL ++++
Sbjct: 98 SIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGA 157
Query: 547 GFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLEL 726
G DVKALRAFRVLRPLRLVSGVPSLQVVLN+I +AM+PL HIALLVLF+++IYAIIGLEL
Sbjct: 158 GLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLEL 217
Query: 727 FCGKLHSTCIDPATGQLA---QKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTW 897
F GK+H TC T +A ++P+PC GS +C + S EC
Sbjct: 218 FKGKMHKTCYFIGTDIVATVENEEPSPCART--GSGRRCTINGS--------ECRGGC-- 265
Query: 898 PGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFV 1077
PGPN+GIT+FDNFG +MLTV+QC+++EGWTDV+YWVNDA+G EWPWIYFVTL++LGSFF+
Sbjct: 266 PGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFI 325
Query: 1078 LNLVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAE--DIEPVNEDE 1251
LNLVLGVLSGEF+KEREKA++RG FQK REKQQL+EDL+GY+ WITQ E D+E E +
Sbjct: 326 LNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLDEDLRGYMSWITQGEVMDVEDFREGK 385
Query: 1252 QE-DEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFY 1428
DE + T +K ++ + N +VKS+ FY
Sbjct: 386 LSLDEGGSDTESLYEIAGL----------NKIIQFIRHWRQWNRIFRWKCHDIVKSKVFY 435
Query: 1429 WXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQ 1608
W SEH+ Q WL Q +AN + LF+ EML+KMY LG Y S
Sbjct: 436 WLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSI 495
Query: 1609 FNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXX 1788
FNRFDCFVV S ILE +LV M PLG+SVLR RLLRIFK+TKYWT
Sbjct: 496 FNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNS 555
Query: 1789 XXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGE 1968
GMQ+FGG+++F + + R+NFD F QAL++VFQ+LTGE
Sbjct: 556 IRSIASLLLLLFLFIVIFRLLGMQLFGGRYDFEDTEVR-RSNFDNFPQALISVFQVLTGE 614
Query: 1969 DWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNA 2145
DW ++MY+GI ++ G G++VCIY+I+LF+CGNYILLNVFLAIAVDNLA+A+SLT+A
Sbjct: 615 DWTSMMYNGIMAYRGPSYPGMLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTSA 673
Score = 159 bits (403), Expect = 6e-37
Identities = 149/685 (21%), Positives = 278/685 (39%), Gaps = 87/685 (12%)
Frame = +1
Query: 2308 KPIPKA-----SSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQA- 2469
KP+P+ +LF L+ N R C +V F +L I + LA P+
Sbjct: 18 KPVPEILPSPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPED 77
Query: 2470 -NSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSF 2646
N++ N+ L +YFF VF++E +K+I +G +FH+ ++ R+ +N+LD +V + + +
Sbjct: 78 DNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTV 137
Query: 2647 VLR--------TDAMSXXXXXXXXXXXXXXXAINRAK------GLKHVVQCVIVAVKTIG 2784
+L T MS + + L+ V+ + A+ +
Sbjct: 138 ILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLF 197
Query: 2785 NIMLVTFMLQFMFAIIGVQLFKGT-----FFLCNDLSKMTEAECRGEYIHYEDGDPTKPV 2949
+I L+ + ++AIIG++LFKG +F+ D+ E E E +
Sbjct: 198 HIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENE--------EPSPCARTG 249
Query: 2950 SKKRVWSNND-------------FNFDNVGDAMISLFVVSTFEG---------------W 3045
S +R N +FDN G +M++++ T EG W
Sbjct: 250 SGRRCTINGSECRGGCPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEW 309
Query: 3046 PQLLYVAID-------------------SNEEDKGPIHNSRQAVALXXXXXXXXXXXXXX 3168
P + +V + + E +K + Q +
Sbjct: 310 PWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLDEDLRGYMSW 369
Query: 3169 XXXXGFVIVTFQNEGEREYENCELDKNQ-------RKCIEFALKAKPHRRYIPRNRL-QY 3324
+ V EG+ + D K I+F R + NR+ ++
Sbjct: 370 ITQGEVMDVEDFREGKLSLDEGGSDTESLYEIAGLNKIIQFI------RHWRQWNRIFRW 423
Query: 3325 RVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKI 3504
+ V S+ F +++ LI+ +NT+S+A +H+ D+ N + +F E ++K+
Sbjct: 424 KCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTTEMLMKM 483
Query: 3505 VALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSR 3684
L + Y +N FD VV ++I + G + I+ R R++R+ K+
Sbjct: 484 YGLGLRQYFMSIFNRFDCFVVCSGILEILL--VESGAMTPLGISVLRCIRLLRIFKITKY 541
Query: 3685 GEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSF 3864
+ L+ + + S +++ + LL+ L I+ ++GMQ FG + T + R +NF +F
Sbjct: 542 WTSLSNLVASLLNSIRSIASLLLLLFLFIVIFRLLGMQLFGGRYDFEDTEV-RRSNFDNF 600
Query: 3865 PAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP----- 4029
P A++ +F+ TGE W +M N +YP
Sbjct: 601 PQALISVFQVLTGEDWTSMM----------------------YNGIMAYRGPSYPGMLVC 638
Query: 4030 -YFISFFMLCSFLVINLFVAVIMDN 4101
YFI F+ +++++N+F+A+ +DN
Sbjct: 639 IYFIILFVCGNYILLNVFLAIAVDN 663
Score = 108 bits (270), Expect = 1e-21
Identities = 97/340 (28%), Positives = 156/340 (45%), Gaps = 9/340 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V N IR LC IV F IL I + AL
Sbjct: 757 RPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAAL 816
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P A +N +L+ + F VFT+E VLK+ G H ++ RN +N+LD +
Sbjct: 817 AAEDPIRADSM--RNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLL 874
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S L +I VK LR RVLRPLR ++ L+ + AI + +I
Sbjct: 875 VVAVSLISMGLESSAIS--VVKILRVLRVLRPLRAINRAKGLKCMFVAI----STIGNIV 928
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLT 855
L+ + ++A IG++LF GK C D L++ C G + + D +
Sbjct: 929 LVTTLLQFMFACIGVQLFKGKFF-RCTD-----LSKMTEEEC----RGYYYVYKDGDPM- 977
Query: 856 NMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDA----VG- 1020
+ +R + W + +FDN AM+++F + EGW ++Y D+ VG
Sbjct: 978 QIELR-----HREWV---HSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGP 1029
Query: 1021 ----REWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKERE 1128
R I+F+ +IL +FF++N+ +G + F ++ E
Sbjct: 1030 IYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGE 1069
Score = 85.5 bits (210), Expect = 1e-14
Identities = 80/338 (23%), Positives = 140/338 (40%), Gaps = 41/338 (12%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP + IV FE+L+ +I N I L + Q Y S+ N + + + F ++F
Sbjct: 1101 NPYQYQVWYIVTSSYFEYLMFALIMLNTICLGM-QHY--NQSEQMNHISDILNVAFTIIF 1157
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKM-----SIQGF----- 552
T+E +LK++A F Y N WN+ DF+IV+ ++ ILS++ S G
Sbjct: 1158 TLEMILKLMA----FKARGYFGNPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGG 1213
Query: 553 -------DVKA------LRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFV 693
D A R FRV+R ++L+S ++ +L +++ L ++ALL++ +
Sbjct: 1214 GCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVML 1273
Query: 694 ILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRW 873
IYA+IG+++F G++A D T
Sbjct: 1274 FFIYAVIGMQMF-------------GKIALVDGTQI------------------------ 1296
Query: 874 ECSSNTTWPGPNNGITNFDNFGLAMLTVFQ--CVSLEGWTDVMYWVN------------- 1008
N NF F A+L +F+ C + E W +++ +
Sbjct: 1297 ------------NRNNNFQTFPQAVLLLFRHACATGEAWQEILLACSYGKLCDPESDYAP 1344
Query: 1009 ---DAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
G + + YF++ +L +F V+NL + V+ F
Sbjct: 1345 GEEYTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNF 1382
Score = 73.6 bits (179), Expect = 5e-11
Identities = 68/309 (22%), Positives = 127/309 (41%), Gaps = 57/309 (18%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDV----FNLIFTGVFAFEAVLKIVA-- 3510
+ FE +I L I N V+LA + P + L++ F VF+ EA +KI+A
Sbjct: 51 KPFETIILLTIFANCVALAV-YLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYG 109
Query: 3511 --LNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNL---------ISINFFRLFRV 3657
+ Y+ WNV D +V + ++N ++ + + R FRV
Sbjct: 110 FLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRV 169
Query: 3658 MRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GK-------V 3813
+R ++L+S ++ +L + K+ L ++ALL++ + IYA+IG++ F GK +
Sbjct: 170 LRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFI 229
Query: 3814 ALDDSTSI--------------------------------HRNNNFHSFPAAILVLFRSA 3897
D ++ H +F +F ++L +++
Sbjct: 230 GTDIVATVENEEPSPCARTGSGRRCTINGSECRGGCPGPNHGITHFDNFGFSMLTVYQCI 289
Query: 3898 TGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINL 4077
T E W D++ +D GN + + YF++ +L SF ++NL
Sbjct: 290 TMEGWTDVLYWVNDA---------------------IGNEWPWIYFVTLILLGSFFILNL 328
Query: 4078 FVAVIMDNF 4104
+ V+ F
Sbjct: 329 VLGVLSGEF 337
Score = 70.1 bits (170), Expect = 6e-10
Identities = 58/249 (23%), Positives = 99/249 (39%), Gaps = 36/249 (14%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HY QSE ++H + N+ F I+F++EM+LK+ + Y + +N FD +VI SI++
Sbjct: 1134 QHYNQSEQMNHISDILNVAFTIIFTLEMILKLMAFKARGYFGNPWNVFDFLIVIGSIIDV 1193
Query: 1657 VLVYFDLM----------------------KPLGVSVLRSARLLRIFKVTKYWTXXXXXX 1770
+L D + + R R++R+ K+
Sbjct: 1194 ILSEIDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLL 1253
Query: 1771 XXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVF 1950
GMQ+FG + Q NF TF QA+L +F
Sbjct: 1254 WTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLF 1313
Query: 1951 Q--ILTGEDWNTVMY----------HGIESFGGVGTLGVIVCIYYIVLF--ICGNYILLN 2088
+ TGE W ++ + G T G YY + F +C ++++N
Sbjct: 1314 RHACATGEAWQEILLACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCA-FLVIN 1372
Query: 2089 VFLAIAVDN 2115
+F+A+ +DN
Sbjct: 1373 LFVAVIMDN 1381
Score = 42.7 bits (99), Expect = 0.10
Identities = 48/245 (19%), Positives = 98/245 (39%), Gaps = 38/245 (15%)
Frame = +1
Query: 1489 QSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEF 1656
+++ L HF ++ F +F++E++LKM + G ++ + FN D VV S++
Sbjct: 828 RNQILKHF----DIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISM 883
Query: 1657 VLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1836
L + +SV++ R+LR+ + +
Sbjct: 884 GL------ESSAISVVKILRVLRVLRPLRA-INRAKGLKCMFVAISTIGNIVLVTTLLQF 936
Query: 1837 XXXXXGMQVFGGKF----------------------NFNPQQPKPRA--------NFDTF 1926
G+Q+F GKF + +P Q + R +FD
Sbjct: 937 MFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHREWVHSDFHFDNV 996
Query: 1927 VQALLTVFQILTGEDWNTVMYHGIES----FGGVGTLGVIVCIYYIVLFICGNYILLNVF 2094
+ A++++F + T E W ++Y I+S G + V + I++I+ I + ++N+F
Sbjct: 997 LSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIF 1056
Query: 2095 LAIAV 2109
+ +
Sbjct: 1057 VGFVI 1061
>gi|15131669|emb|CAC48390.1| voltage-gated calcium channel alpha1
subunit [Mesocricetus auratus]
Length = 1602
Score = 962 bits (2488), Expect = 0.0
Identities = 474/759 (62%), Positives = 579/759 (75%), Gaps = 16/759 (2%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPRR+SE+ + PIP+ S+ FILS TN RV C+ ++NH FTN +L I++SSA L
Sbjct: 834 RPRRISELNMKEKIVPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAAL 893
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP++++S RN IL YFDY FT++FTVEI LK+ FG HKG+FCRN FNLLD+LVV
Sbjct: 894 AAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVV 953
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
VSL SF +++ A+S AINRAKGLKHVVQCV VA++TIGNIM+VT
Sbjct: 954 GVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTT 1013
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG F+ C D +K ECRG +I Y+DGD PV ++R+W N+DFN
Sbjct: 1014 LLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFN 1073
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP LLY AIDSN E+ GP++N R +++
Sbjct: 1074 FDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENAGPVYNHRVEISIFFIIYIIIVAFFM 1133
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N QY+ W+ V
Sbjct: 1134 MNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVN 1193
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S+ F D +D+ N++FTGVF E VLK++A PK
Sbjct: 1194 SSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKG 1253
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGGT----------------NLISINFFRLFRV 3657
Y SD WN FD L+V+GS ID+ + +P + N ISI FFRLFRV
Sbjct: 1254 YFSDAWNTFDSLIVIGSIIDVALSEADPTESESLPLPTATPGNSEESNRISITFFRLFRV 1313
Query: 3658 MRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSI 3837
MRLVKLLSRGEGIRTLLWTF+KSFQALPYVALLI +LFFIYAVIGMQ FGKVA+ D+ I
Sbjct: 1314 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQI 1373
Query: 3838 HRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNN 4017
+RNNNF +FP A+L+LFR ATGEAWQ+IML+C + CDP SD Y+ G E CG+N
Sbjct: 1374 NRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGK--LCDPDSD-YNPG--EEYTCGSN 1428
Query: 4018 FAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKG 4197
FA YFISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+WSEYDP+AKG
Sbjct: 1429 FAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKG 1488
Query: 4198 RIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNL 4377
RIKHLDVVTLLR+I PPLGFGKLCPHR+ACKRLV+MNMPLNSDGTV FNATLFALVRT L
Sbjct: 1489 RIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTAL 1548
Query: 4378 KIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAG 4494
KI TEGN+++ANE+LR+ IK+IWK+T LLD+VVPPAG
Sbjct: 1549 KIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAG 1587
Score = 715 bits (1846), Expect = 0.0
Identities = 375/669 (56%), Positives = 448/669 (66%), Gaps = 27/669 (4%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
NNPIR+ CISIVEWKPF+ IL I ANC+ALAIY P+P DS+ N LE +EY F+++
Sbjct: 103 NNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLII 162
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQ----------- 546
FT+E LKI+A G + HP+AY+RN WN+LDF+IV++GL S IL +++ +
Sbjct: 163 FTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKS 222
Query: 547 -GFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLE 723
GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+I++AM+PLLHIALLVLFVI+IYAIIGLE
Sbjct: 223 GGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLE 282
Query: 724 LFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPG 903
LF GK+H TC + +A++DP PC G+ +C + + EC S W G
Sbjct: 283 LFIGKMHKTCFFADSDIVAEEDPAPCAFS--GNGRQCAVNGT--------ECRSG--WVG 330
Query: 904 PNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLN 1083
PN GITNFDNF AMLTVFQC+++EGWTDV+YW+NDA+G E PW+YFV+LVI GSFFVLN
Sbjct: 331 PNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLN 390
Query: 1084 LVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDE 1263
LVLGVLSGEFSKEREKA+ARG FQK REKQQLEEDLKGYLDWITQAEDI+P NE+E +E
Sbjct: 391 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEE 450
Query: 1264 -------PVAQTXXXXXXXXXXXXXX--------XXXXPSKWAARMKRLEKLNXXXXXXX 1398
P ++T SK + R +R + N
Sbjct: 451 GKRNTSMPTSETESVNTENVSGEGETQGSCGSLCQAISKSKLSRRWRRWNRFNRRRCRAA 510
Query: 1399 XXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYS 1578
VKS TFYW +SEHY Q +WL Q +AN + LF+ EML+KMYS
Sbjct: 511 ---VKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYS 567
Query: 1579 LGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXX 1758
LG Y S FNRFDCFVV I E +LV +LM PLGVSV R RLLRIFKVT++WT
Sbjct: 568 LGLQAYFVSLFNRFDCFVVCGGITETILVELELMSPLGVSVFRCVRLLRIFKVTRHWTSL 627
Query: 1759 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQAL 1938
GMQ+FGGKFNF+ Q K R+ FD F QAL
Sbjct: 628 SNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTK-RSTFDNFPQAL 686
Query: 1939 LTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNL 2118
LTVFQILTGEDWN VMY GI ++GG + G+IVCIY+I+LFICGNYILLNVFLAIAVDNL
Sbjct: 687 LTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNL 746
Query: 2119 ADADSLTNA 2145
ADA+SL A
Sbjct: 747 ADAESLNTA 755
Score = 128 bits (322), Expect = 1e-27
Identities = 92/312 (29%), Positives = 152/312 (48%), Gaps = 9/312 (2%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR C ++ F LIL I + ALA P + ++NT+L +Y F +F
Sbjct: 863 NPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPI--RSHSFRNTILGYFDYAFTAIF 920
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
T+E +LK+ G H A+ RN +N+LD ++V + LVS + +I VK LR RV
Sbjct: 921 TVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAIS--VVKILRVLRV 978
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLR ++ L+ V+ + A+ + +I ++ + ++A IG++LF GK + C D
Sbjct: 979 LRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFY-RCTDE 1037
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
A+ +P C F + + VR N+ + NFDN
Sbjct: 1038 -----AKSNPEEC-----RGLFILYKDGDVDSPVVRERIWQNSDF--------NFDNVLS 1079
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDAVG---------REWPWIYFVTLVILGSFFVLNLVLG 1095
AM+ +F + EGW ++Y D+ G R I+F+ +I+ +FF++N+ +G
Sbjct: 1080 AMMALFTVSTFEGWPALLYKAIDSNGENAGPVYNHRVEISIFFIIYIIIVAFFMMNIFVG 1139
Query: 1096 VLSGEFSKEREK 1131
+ F ++ EK
Sbjct: 1140 FVIVTFQEQGEK 1151
Score = 102 bits (255), Expect = 8e-20
Identities = 70/276 (25%), Positives = 134/276 (48%), Gaps = 1/276 (0%)
Frame = +1
Query: 3277 KAKPHRRYIPRNRL-QYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDV 3453
K+K RR+ NR + R V S F +++ +++ +NT++++ +HY D+
Sbjct: 489 KSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDI 548
Query: 3454 FNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISI 3633
N + +F E ++K+ +L + Y +N FD VV G + +L + + +
Sbjct: 549 ANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEL--MSPLGV 606
Query: 3634 NFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKV 3813
+ FR R++R+ K+ + L+ + + S +++ + LL+ L I++++GMQ FG
Sbjct: 607 SVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGK 666
Query: 3814 ALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGL 3993
D T R+ F +FP A+L +F+ TGE W +M GG
Sbjct: 667 FNFDETQTKRST-FDNFPQALLTVFQILTGEDWNAVMYD-------------GIMAYGGP 712
Query: 3994 NESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDN 4101
+ S YFI F+ +++++N+F+A+ +DN
Sbjct: 713 SSS---GMIVCIYFIILFICGNYILLNVFLAIAVDN 745
Score = 93.2 bits (230), Expect = 6e-17
Identities = 76/332 (22%), Positives = 135/332 (39%), Gaps = 35/332 (10%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP + +V PFE+++ +I N + LA+ Q Y + S N ++ + VF VF
Sbjct: 1182 NPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAM-QHY--EQSKMFNDAMDILNMVFTGVF 1238
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMS-------------- 540
T+E VLK++A F P Y +AWN D +IV+ ++ LS+
Sbjct: 1239 TVEMVLKVIA----FKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESESLPLPTATP 1294
Query: 541 -----IQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIY 705
+ R FRV+R ++L+S ++ +L +++ L ++ALL+ + IY
Sbjct: 1295 GNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIY 1354
Query: 706 AIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSS 885
A+IG+++F G++A +D
Sbjct: 1355 AVIGMQMF-------------GKVAMRDNNQI---------------------------- 1373
Query: 886 NTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMY----------------WVNDAV 1017
N NF F A+L +F+C + E W ++M
Sbjct: 1374 --------NRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPDSDYNPGEEYTC 1425
Query: 1018 GREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
G + +YF++ +L +F ++NL + V+ F
Sbjct: 1426 GSNFAIVYFISFYMLCAFLIINLFVAVIMDNF 1457
Score = 89.4 bits (220), Expect = 9e-16
Identities = 143/704 (20%), Positives = 254/704 (35%), Gaps = 78/704 (11%)
Frame = +1
Query: 232 RKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIE 411
R+ C + V+ F +L++ ++ N + ++ D+ + + V + +FT E
Sbjct: 504 RRRCRAAVKSVTFYWLVIVLVFLNTLTISSEH---YNQPDWLTQIQDIANKVLLALFTCE 560
Query: 412 CVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG-FDVKALRAFRVLR 588
++K+ ++G AY + +N D +V G+ TIL ++ + V R R+LR
Sbjct: 561 MLVKMYSLGLQ----AYFVSLFNRFDCFVVCGGITETILVELELMSPLGVSVFRCVRLLR 616
Query: 589 PLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPAT 768
++ SL ++ ++L +M + + LL+ I+I++++
Sbjct: 617 IFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLL------------------ 658
Query: 769 GQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAM 948
G G F + + + FDNF A+
Sbjct: 659 -----------GMQLFGGKFNFDETQTKRS---------------------TFDNFPQAL 686
Query: 949 LTVFQCVSLEGWTDVMYWVNDAVGREWP-----WIYFVTLVILGSFFVLNLVLGVLSGEF 1113
LTVFQ ++ E W VMY A G IYF+ L I G++ +LN+ L +
Sbjct: 687 LTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNL 746
Query: 1114 S---------------KEREK-ARARGLFQKFREKQQLEE----DLKGYLD-WITQAEDI 1230
+ KER+K AR L K K ++ + D K +D + + ED
Sbjct: 747 ADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYQEETEDK 806
Query: 1231 EPV--------NEDEQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXX 1386
+P E+E+E+E P + L K N
Sbjct: 807 DPYPPCDVPVGEEEEEEEEEPEVPAGPRPRRISELNMKEKIVPIPEGSAFFILSKTNPIR 866
Query: 1387 XXXXXXLVKSQTFYWXXXXXXXXXXXXXTSE-----HYGQSEWLDHFQTMANLFFVILFS 1551
L+ F +E H ++ L +F + F +F+
Sbjct: 867 VGCHK-LINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYF----DYAFTAIFT 921
Query: 1552 MEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARL 1719
+E+LLKM + G + + FN D VV S++ F + + V +LR R+
Sbjct: 922 VEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISV---VKILRVLRV 978
Query: 1720 LRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF------- 1878
LR + G+Q+F GKF
Sbjct: 979 LRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEA 1038
Query: 1879 NFNPQQ---------------PKPRA--------NFDTFVQALLTVFQILTGEDWNTVMY 1989
NP++ P R NFD + A++ +F + T E W ++Y
Sbjct: 1039 KSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLY 1098
Query: 1990 HGI----ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
I E+ G V V + I++I+ I + ++N+F+ +
Sbjct: 1099 KAIDSNGENAGPVYNHRVEISIFFIIYIIIVAFFMMNIFVGFVI 1142
Score = 88.6 bits (218), Expect = 2e-15
Identities = 78/285 (27%), Positives = 119/285 (41%), Gaps = 39/285 (13%)
Frame = +1
Query: 2323 ASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPL---QANSTRNMIL 2493
A +LF LS N R C +V F +L I + LA P +NST N L
Sbjct: 94 ARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNST-NHNL 152
Query: 2494 NYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL-----RT 2658
+Y F +FTVE LK+I +GL+ H ++ RN +NLLD ++V V L S +L T
Sbjct: 153 EKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKET 212
Query: 2659 DAMSXXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFML 2811
+ + A ++ L+ V+ +I A+ + +I L+ +
Sbjct: 213 EGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFV 272
Query: 2812 QFMFAIIGVQLF-----KGTFFLCNDL-----------------SKMTEAECRGEYIHYE 2925
++AIIG++LF K FF +D+ + ECR ++
Sbjct: 273 IIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCAVNGTECRSGWVGPN 332
Query: 2926 DGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLY 3060
G NFDN AM+++F T EGW +LY
Sbjct: 333 GGIT---------------NFDNFAFAMLTVFQCITMEGWTDVLY 362
Score = 80.9 bits (198), Expect = 3e-13
Identities = 83/352 (23%), Positives = 141/352 (39%), Gaps = 53/352 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ F+ I L I N V+LA +P S L+ F +F E LKI+A
Sbjct: 117 KPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGL 176
Query: 3511 -LNPKNYISDRWNVFDLLVVVGSFIDITYGKL---------NPGGTNLISINFFRLFRVM 3660
L+P Y+ + WN+ D ++V+ + +L + G + + R FRV+
Sbjct: 177 LLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVL 236
Query: 3661 RLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGK--------- 3810
R ++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F GK
Sbjct: 237 RPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFAD 296
Query: 3811 ---VALDDSTSIHRN------------------------NNFHSFPAAILVLFRSATGEA 3909
VA +D + NF +F A+L +F+ T E
Sbjct: 297 SDIVAEEDPAPCAFSGNGRQCAVNGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEG 356
Query: 3910 WQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAV 4089
W D++ +D G + YF+S + SF V+NL + V
Sbjct: 357 WTDVLYWMND---------------------AMGFELPWVYFVSLVIFGSFFVLNLVLGV 395
Query: 4090 IMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
+ F G + +R + + D KG +LD +T I P
Sbjct: 396 LSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 441
Score = 68.6 bits (166), Expect = 2e-09
Identities = 53/245 (21%), Positives = 98/245 (39%), Gaps = 32/245 (13%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HY QS+ + + N+ F +F++EM+LK+ + Y + +N FD +VI SI++
Sbjct: 1215 QHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDV 1274
Query: 1657 VLVYFDLMKP------------------LGVSVLRSARLLRIFKVTKYWTXXXXXXXXXX 1782
L D + + ++ R R++R+ K+
Sbjct: 1275 ALSEADPTESESLPLPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFI 1334
Query: 1783 XXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILT 1962
GMQ+FG + Q NF TF QA+L +F+ T
Sbjct: 1335 KSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCAT 1394
Query: 1963 GEDWNTVM--------------YHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLA 2100
GE W +M Y+ E + + +Y+I ++ ++++N+F+A
Sbjct: 1395 GEAWQEIMLACLPGKLCDPDSDYNPGEEYTCGSNFAI---VYFISFYMLCAFLIINLFVA 1451
Query: 2101 IAVDN 2115
+ +DN
Sbjct: 1452 VIMDN 1456
>gi|6165986|sp|Q99244|CCAD_MESAU Voltage-dependent L-type calcium
channel alpha-1D subunit (Voltage-gated calcium channel
alpha subunit Cav1.3) (Calcium channel, L type, alpha-1
polypeptide isoform 2)
gi|476878|pir||A46227 voltage-dependent Ca2+ channel alpha 1-subunit
- golden hamster
gi|264414|gb|AAB25139.1| voltage-dependent Ca2+ channel alpha
1-subunit [hamsters, insulin-secreting cell line HIT-T15,
Peptide, 1610 aa]
Length = 1610
Score = 962 bits (2488), Expect = 0.0
Identities = 474/759 (62%), Positives = 579/759 (75%), Gaps = 16/759 (2%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPRR+SE+ + PIP+ S+ FILS TN RV C+ ++NH FTN +L I++SSA L
Sbjct: 842 RPRRISELNMKEKIVPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAAL 901
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP++++S RN IL YFDY FT++FTVEI LK+ FG HKG+FCRN FNLLD+LVV
Sbjct: 902 AAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVV 961
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
VSL SF +++ A+S AINRAKGLKHVVQCV VA++TIGNIM+VT
Sbjct: 962 GVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTT 1021
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG F+ C D +K ECRG +I Y+DGD PV ++R+W N+DFN
Sbjct: 1022 LLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFN 1081
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP LLY AIDSN E+ GP++N R +++
Sbjct: 1082 FDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENAGPVYNHRVEISIFFIIYIIIVAFFM 1141
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N QY+ W+ V
Sbjct: 1142 MNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVN 1201
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S+ F D +D+ N++FTGVF E VLK++A PK
Sbjct: 1202 SSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKG 1261
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGGT----------------NLISINFFRLFRV 3657
Y SD WN FD L+V+GS ID+ + +P + N ISI FFRLFRV
Sbjct: 1262 YFSDAWNTFDSLIVIGSIIDVALSEADPTESESLPLPTATPGNSEESNRISITFFRLFRV 1321
Query: 3658 MRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSI 3837
MRLVKLLSRGEGIRTLLWTF+KSFQALPYVALLI +LFFIYAVIGMQ FGKVA+ D+ I
Sbjct: 1322 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQI 1381
Query: 3838 HRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNN 4017
+RNNNF +FP A+L+LFR ATGEAWQ+IML+C + CDP SD Y+ G E CG+N
Sbjct: 1382 NRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGK--LCDPDSD-YNPG--EEYTCGSN 1436
Query: 4018 FAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKG 4197
FA YFISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+WSEYDP+AKG
Sbjct: 1437 FAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKG 1496
Query: 4198 RIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNL 4377
RIKHLDVVTLLR+I PPLGFGKLCPHR+ACKRLV+MNMPLNSDGTV FNATLFALVRT L
Sbjct: 1497 RIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTAL 1556
Query: 4378 KIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAG 4494
KI TEGN+++ANE+LR+ IK+IWK+T LLD+VVPPAG
Sbjct: 1557 KIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAG 1595
Score = 712 bits (1838), Expect = 0.0
Identities = 373/669 (55%), Positives = 447/669 (66%), Gaps = 27/669 (4%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
NNPIR+ CISIVEWKPF+ IL I ANC+ALAIY P+P DS+ N LE +EY F+++
Sbjct: 111 NNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLII 170
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQ----------- 546
FT+E LKI+A G + HP+AY+RN WN+LDF+IV++GL S IL +++ +
Sbjct: 171 FTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKS 230
Query: 547 -GFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLE 723
GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+I++AM+PLLHIALLVLFVI+IYAIIGLE
Sbjct: 231 GGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLE 290
Query: 724 LFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPG 903
LF GK+H TC + +A++DP PC G+ +C + + EC S W G
Sbjct: 291 LFIGKMHKTCFFADSDIVAEEDPAPCAFS--GNGRQCAVNGT--------ECRSG--WVG 338
Query: 904 PNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLN 1083
PN GITNFDNF AMLTVFQC+++EGWTDV+YW+NDA+G E PW+YFV+LVI GSFFVLN
Sbjct: 339 PNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLN 398
Query: 1084 LVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDE 1263
LVLGVLSGEFSKEREKA+ARG FQK RE +QLEEDLKGYLDWITQAEDI+P NE+E +E
Sbjct: 399 LVLGVLSGEFSKEREKAKARGDFQKLRENEQLEEDLKGYLDWITQAEDIDPENEEEGGEE 458
Query: 1264 -------PVAQTXXXXXXXXXXXXXX--------XXXXPSKWAARMKRLEKLNXXXXXXX 1398
P ++T SK + R +R + N
Sbjct: 459 GKRNTSMPTSETESVNTENVSGEGETQGSCGSLCQAISKSKLSRRWRRWNRFNRRRCRAA 518
Query: 1399 XXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYS 1578
VKS TFYW +SEHY Q +WL Q +AN + LF+ EML+KMYS
Sbjct: 519 ---VKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYS 575
Query: 1579 LGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXX 1758
LG Y S FNRFDCFVV I E +LV +LM PLGVSV R RLLRIFKVT++WT
Sbjct: 576 LGLQAYFVSLFNRFDCFVVCGGITETILVELELMSPLGVSVFRCVRLLRIFKVTRHWTSL 635
Query: 1759 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQAL 1938
GMQ+FGGKFNF+ Q K R+ FD F QAL
Sbjct: 636 SNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTK-RSTFDNFPQAL 694
Query: 1939 LTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNL 2118
LTVFQILTGEDWN VMY GI ++GG + G+IVCIY+I+LFICGNYILLNVFLAIAVDNL
Sbjct: 695 LTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNL 754
Query: 2119 ADADSLTNA 2145
ADA+SL A
Sbjct: 755 ADAESLNTA 763
Score = 128 bits (322), Expect = 1e-27
Identities = 92/312 (29%), Positives = 152/312 (48%), Gaps = 9/312 (2%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR C ++ F LIL I + ALA P + ++NT+L +Y F +F
Sbjct: 871 NPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPI--RSHSFRNTILGYFDYAFTAIF 928
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
T+E +LK+ G H A+ RN +N+LD ++V + LVS + +I VK LR RV
Sbjct: 929 TVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAIS--VVKILRVLRV 986
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLR ++ L+ V+ + A+ + +I ++ + ++A IG++LF GK + C D
Sbjct: 987 LRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFY-RCTDE 1045
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
A+ +P C F + + VR N+ + NFDN
Sbjct: 1046 -----AKSNPEEC-----RGLFILYKDGDVDSPVVRERIWQNSDF--------NFDNVLS 1087
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDAVG---------REWPWIYFVTLVILGSFFVLNLVLG 1095
AM+ +F + EGW ++Y D+ G R I+F+ +I+ +FF++N+ +G
Sbjct: 1088 AMMALFTVSTFEGWPALLYKAIDSNGENAGPVYNHRVEISIFFIIYIIIVAFFMMNIFVG 1147
Query: 1096 VLSGEFSKEREK 1131
+ F ++ EK
Sbjct: 1148 FVIVTFQEQGEK 1159
Score = 102 bits (255), Expect = 8e-20
Identities = 70/276 (25%), Positives = 134/276 (48%), Gaps = 1/276 (0%)
Frame = +1
Query: 3277 KAKPHRRYIPRNRL-QYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDV 3453
K+K RR+ NR + R V S F +++ +++ +NT++++ +HY D+
Sbjct: 497 KSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDI 556
Query: 3454 FNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISI 3633
N + +F E ++K+ +L + Y +N FD VV G + +L + + +
Sbjct: 557 ANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEL--MSPLGV 614
Query: 3634 NFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKV 3813
+ FR R++R+ K+ + L+ + + S +++ + LL+ L I++++GMQ FG
Sbjct: 615 SVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGK 674
Query: 3814 ALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGL 3993
D T R+ F +FP A+L +F+ TGE W +M GG
Sbjct: 675 FNFDETQTKRST-FDNFPQALLTVFQILTGEDWNAVMYD-------------GIMAYGGP 720
Query: 3994 NESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDN 4101
+ S YFI F+ +++++N+F+A+ +DN
Sbjct: 721 SSS---GMIVCIYFIILFICGNYILLNVFLAIAVDN 753
Score = 93.2 bits (230), Expect = 6e-17
Identities = 76/332 (22%), Positives = 135/332 (39%), Gaps = 35/332 (10%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP + +V PFE+++ +I N + LA+ Q Y + S N ++ + VF VF
Sbjct: 1190 NPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAM-QHY--EQSKMFNDAMDILNMVFTGVF 1246
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMS-------------- 540
T+E VLK++A F P Y +AWN D +IV+ ++ LS+
Sbjct: 1247 TVEMVLKVIA----FKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESESLPLPTATP 1302
Query: 541 -----IQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIY 705
+ R FRV+R ++L+S ++ +L +++ L ++ALL+ + IY
Sbjct: 1303 GNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIY 1362
Query: 706 AIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSS 885
A+IG+++F G++A +D
Sbjct: 1363 AVIGMQMF-------------GKVAMRDNNQI---------------------------- 1381
Query: 886 NTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMY----------------WVNDAV 1017
N NF F A+L +F+C + E W ++M
Sbjct: 1382 --------NRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPDSDYNPGEEYTC 1433
Query: 1018 GREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
G + +YF++ +L +F ++NL + V+ F
Sbjct: 1434 GSNFAIVYFISFYMLCAFLIINLFVAVIMDNF 1465
Score = 89.4 bits (220), Expect = 9e-16
Identities = 143/704 (20%), Positives = 254/704 (35%), Gaps = 78/704 (11%)
Frame = +1
Query: 232 RKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIE 411
R+ C + V+ F +L++ ++ N + ++ D+ + + V + +FT E
Sbjct: 512 RRRCRAAVKSVTFYWLVIVLVFLNTLTISSEH---YNQPDWLTQIQDIANKVLLALFTCE 568
Query: 412 CVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG-FDVKALRAFRVLR 588
++K+ ++G AY + +N D +V G+ TIL ++ + V R R+LR
Sbjct: 569 MLVKMYSLGLQ----AYFVSLFNRFDCFVVCGGITETILVELELMSPLGVSVFRCVRLLR 624
Query: 589 PLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPAT 768
++ SL ++ ++L +M + + LL+ I+I++++
Sbjct: 625 IFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLL------------------ 666
Query: 769 GQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAM 948
G G F + + + FDNF A+
Sbjct: 667 -----------GMQLFGGKFNFDETQTKRS---------------------TFDNFPQAL 694
Query: 949 LTVFQCVSLEGWTDVMYWVNDAVGREWP-----WIYFVTLVILGSFFVLNLVLGVLSGEF 1113
LTVFQ ++ E W VMY A G IYF+ L I G++ +LN+ L +
Sbjct: 695 LTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNL 754
Query: 1114 S---------------KEREK-ARARGLFQKFREKQQLEE----DLKGYLD-WITQAEDI 1230
+ KER+K AR L K K ++ + D K +D + + ED
Sbjct: 755 ADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYQEETEDK 814
Query: 1231 EPV--------NEDEQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXX 1386
+P E+E+E+E P + L K N
Sbjct: 815 DPYPPCDVPVGEEEEEEEEEPEVPAGPRPRRISELNMKEKIVPIPEGSAFFILSKTNPIR 874
Query: 1387 XXXXXXLVKSQTFYWXXXXXXXXXXXXXTSE-----HYGQSEWLDHFQTMANLFFVILFS 1551
L+ F +E H ++ L +F + F +F+
Sbjct: 875 VGCHK-LINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYF----DYAFTAIFT 929
Query: 1552 MEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARL 1719
+E+LLKM + G + + FN D VV S++ F + + V +LR R+
Sbjct: 930 VEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISV---VKILRVLRV 986
Query: 1720 LRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF------- 1878
LR + G+Q+F GKF
Sbjct: 987 LRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEA 1046
Query: 1879 NFNPQQ---------------PKPRA--------NFDTFVQALLTVFQILTGEDWNTVMY 1989
NP++ P R NFD + A++ +F + T E W ++Y
Sbjct: 1047 KSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLY 1106
Query: 1990 HGI----ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
I E+ G V V + I++I+ I + ++N+F+ +
Sbjct: 1107 KAIDSNGENAGPVYNHRVEISIFFIIYIIIVAFFMMNIFVGFVI 1150
Score = 88.6 bits (218), Expect = 2e-15
Identities = 78/285 (27%), Positives = 119/285 (41%), Gaps = 39/285 (13%)
Frame = +1
Query: 2323 ASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPL---QANSTRNMIL 2493
A +LF LS N R C +V F +L I + LA P +NST N L
Sbjct: 102 ARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNST-NHNL 160
Query: 2494 NYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL-----RT 2658
+Y F +FTVE LK+I +GL+ H ++ RN +NLLD ++V V L S +L T
Sbjct: 161 EKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKET 220
Query: 2659 DAMSXXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFML 2811
+ + A ++ L+ V+ +I A+ + +I L+ +
Sbjct: 221 EGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFV 280
Query: 2812 QFMFAIIGVQLF-----KGTFFLCNDL-----------------SKMTEAECRGEYIHYE 2925
++AIIG++LF K FF +D+ + ECR ++
Sbjct: 281 IIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCAVNGTECRSGWVGPN 340
Query: 2926 DGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLY 3060
G NFDN AM+++F T EGW +LY
Sbjct: 341 GGIT---------------NFDNFAFAMLTVFQCITMEGWTDVLY 370
Score = 80.5 bits (197), Expect = 4e-13
Identities = 83/352 (23%), Positives = 141/352 (39%), Gaps = 53/352 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ F+ I L I N V+LA +P S L+ F +F E LKI+A
Sbjct: 125 KPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGL 184
Query: 3511 -LNPKNYISDRWNVFDLLVVVGSFIDITYGKL---------NPGGTNLISINFFRLFRVM 3660
L+P Y+ + WN+ D ++V+ + +L + G + + R FRV+
Sbjct: 185 LLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVL 244
Query: 3661 RLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGK--------- 3810
R ++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F GK
Sbjct: 245 RPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFAD 304
Query: 3811 ---VALDDSTSIHRN------------------------NNFHSFPAAILVLFRSATGEA 3909
VA +D + NF +F A+L +F+ T E
Sbjct: 305 SDIVAEEDPAPCAFSGNGRQCAVNGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEG 364
Query: 3910 WQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAV 4089
W D++ +D G + YF+S + SF V+NL + V
Sbjct: 365 WTDVLYWMND---------------------AMGFELPWVYFVSLVIFGSFFVLNLVLGV 403
Query: 4090 IMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
+ F G + +R + + D KG +LD +T I P
Sbjct: 404 LSGEFSKEREKAKARGDF---QKLRENEQLEEDLKG---YLDWITQAEDIDP 449
Score = 68.6 bits (166), Expect = 2e-09
Identities = 53/245 (21%), Positives = 98/245 (39%), Gaps = 32/245 (13%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HY QS+ + + N+ F +F++EM+LK+ + Y + +N FD +VI SI++
Sbjct: 1223 QHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDV 1282
Query: 1657 VLVYFDLMKP------------------LGVSVLRSARLLRIFKVTKYWTXXXXXXXXXX 1782
L D + + ++ R R++R+ K+
Sbjct: 1283 ALSEADPTESESLPLPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFI 1342
Query: 1783 XXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILT 1962
GMQ+FG + Q NF TF QA+L +F+ T
Sbjct: 1343 KSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCAT 1402
Query: 1963 GEDWNTVM--------------YHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLA 2100
GE W +M Y+ E + + +Y+I ++ ++++N+F+A
Sbjct: 1403 GEAWQEIMLACLPGKLCDPDSDYNPGEEYTCGSNFAI---VYFISFYMLCAFLIINLFVA 1459
Query: 2101 IAVDN 2115
+ +DN
Sbjct: 1460 VIMDN 1464
>gi|1588292|prf||2208308A Ca channel:SUBUNIT=alpha:ISOTYPE=L
Length = 1862
Score = 960 bits (2481), Expect = 0.0
Identities = 506/875 (57%), Positives = 615/875 (69%), Gaps = 28/875 (3%)
Frame = +1
Query: 2260 SARPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSA 2439
S RPR ++E+ PIP+ASS FI S TN RV C+ +VN ++FTN +L IL+SSA
Sbjct: 755 SPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSA 814
Query: 2440 MLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDIL 2619
LAAEDP++A+S RN IL +FD FTSVFTVEI LK+ +G HKGSFCRN FN+LD+L
Sbjct: 815 ALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLL 874
Query: 2620 VVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLV 2799
VVAVSL S L + A+S AINRAKGLK C+ VA+ TIGNI+LV
Sbjct: 875 VVAVSLISMGLESSAISVVKILRVLRVLRPLRAINRAKGLK----CMFVAISTIGNIVLV 930
Query: 2800 TFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNND 2979
T +LQFMFA IGVQLFKG FF C DLSKMTE ECRG Y Y+DGDP + + R W ++D
Sbjct: 931 TTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHREWVHSD 990
Query: 2980 FNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXX 3159
F+FDNV AM+SLF VSTFEGWPQLLY AIDSN ED GPI+N+R +A+
Sbjct: 991 FHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIILIAF 1050
Query: 3160 XXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWF 3339
GFVIVTFQ +GE EY+NCELDKNQR+C+++ALKA+P R YIP+N QY+VW+
Sbjct: 1051 FMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQVWYI 1110
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
VTS FEY++F +I++NT+ L +HY S D+ N+ FT +F E +LK++A
Sbjct: 1111 VTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMAFKA 1170
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITY--------------------GKLNPGGTNLISINF 3639
+ Y + WNVFD L+V+GS ID+ G ++P + IS F
Sbjct: 1171 RGYFGNPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARISSAF 1230
Query: 3640 FRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVAL 3819
FRLFRVMRL+KLLSR EG+RTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL
Sbjct: 1231 FRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIAL 1290
Query: 3820 DDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNE 3999
D T I+RNNNF +FP A+L+LFR ATGEAWQ+I+L+CS + CDP SD Y G E
Sbjct: 1291 VDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGK--LCDPESD-YAPG--EE 1345
Query: 4000 SRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEY 4179
CG NFAY YFISF+MLC+FLVINLFVAVIMDNFDYLTRDWSILGPHHL+EF +W+EY
Sbjct: 1346 YTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAEY 1405
Query: 4180 DPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFA 4359
DP+AKGRIKHLDVVTLLR+I PPLGFGK CPHR+ACKRLV MNMPLNSDGTV FNATLFA
Sbjct: 1406 DPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFA 1465
Query: 4360 LVRTNLKIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFL 4539
LV T LKI TEGN ++ANE+LR+ IK+IWKRT LLD+V +D+VTVGKFYATFL
Sbjct: 1466 LVGTALKIKTEGNFEQANEELRAIIKKIWKRTSMKLLDQV------DDEVTVGKFYATFL 1519
Query: 4540 IQDYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTL-HEIGPELKRAISGNLETDFNFD 4716
IQ+ FR+F KR+E E G P + + +QAGLRT+ E PE+ R +SG+L + +
Sbjct: 1520 IQEDFRKFMKRQE-EYYGYRPKK--DIVQIQAGLRTIEEEAAPEICRTVSGDLAAEEELE 1576
Query: 4717 E-------PEPQHRRPHSLFNNLVHRLSGAGSKSP 4800
E RR LF + + L S P
Sbjct: 1577 RAMVEAAMEEGIFRRTGGLFGQVDNFLERTNSLPP 1611
Score = 657 bits (1696), Expect = 0.0
Identities = 343/659 (52%), Positives = 436/659 (66%), Gaps = 18/659 (2%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+RK CISIVEWKPFE +IL I ANC+ALA+Y P P D++ N LE +EY F++VF
Sbjct: 38 NPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVF 97
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSI------------Q 546
+IE +KI+A GF+FH AYLR+ WN+LDF IV +G+ + IL ++++
Sbjct: 98 SIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGA 157
Query: 547 GFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLEL 726
G DVKALRAFRVLRPLRLVSGVPSLQVVLN+I +AM+PL HIALLVLF+++IYAIIGLEL
Sbjct: 158 GLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLEL 217
Query: 727 FCGKLHSTCIDPATGQLA---QKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTW 897
F GK+H TC T +A ++P+PC GS +C + S EC
Sbjct: 218 FKGKMHKTCYFIGTDIVATVENEEPSPCART--GSGRRCTINGS--------ECRGGC-- 265
Query: 898 PGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFV 1077
PGPN+GIT+FDNFG +MLTV+QC+++EGWTDV+YWVNDA+G EWPWIYFVTL++LGSFF+
Sbjct: 266 PGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFI 325
Query: 1078 LNLVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAE--DIEPVNEDE 1251
LNLVLGVLSGEF+KEREKA++RG FQK REKQQL+EDL+GY+ WITQ E D+E E +
Sbjct: 326 LNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLDEDLRGYMSWITQGEVMDVEDFREGK 385
Query: 1252 QE-DEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFY 1428
DE + T +K ++ + N +VKS+ FY
Sbjct: 386 LSLDEGGSDTESLYEIAGL----------NKIIQFIRHWRQWNRIFRWKCHDIVKSKVFY 435
Query: 1429 WXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQ 1608
W SEH+ Q WL Q +AN + LF+ EML+KMY LG Y S
Sbjct: 436 WLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSI 495
Query: 1609 FNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXX 1788
FNRFDCFVV S ILE +LV M PLG+SVLR RLLRIFK+TKYWT
Sbjct: 496 FNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNS 555
Query: 1789 XXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGE 1968
GMQ+FGG+++F + + R+NFD F QAL++VFQ+LTGE
Sbjct: 556 IRSIASLLLLLFLFIVIFRLLGMQLFGGRYDFEDTEVR-RSNFDNFPQALISVFQVLTGE 614
Query: 1969 DWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNA 2145
DW ++MY+GI ++ G G++VCIY+I+LF+CGNYILLNVFLAIAVDNLA+A+SLT+A
Sbjct: 615 DWTSMMYNGIMAYRGPSYPGMLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTSA 673
Score = 159 bits (403), Expect = 6e-37
Identities = 149/685 (21%), Positives = 278/685 (39%), Gaps = 87/685 (12%)
Frame = +1
Query: 2308 KPIPKA-----SSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQA- 2469
KP+P+ +LF L+ N R C +V F +L I + LA P+
Sbjct: 18 KPVPEILPSPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPED 77
Query: 2470 -NSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSF 2646
N++ N+ L +YFF VF++E +K+I +G +FH+ ++ R+ +N+LD +V + + +
Sbjct: 78 DNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTV 137
Query: 2647 VLR--------TDAMSXXXXXXXXXXXXXXXAINRAK------GLKHVVQCVIVAVKTIG 2784
+L T MS + + L+ V+ + A+ +
Sbjct: 138 ILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLF 197
Query: 2785 NIMLVTFMLQFMFAIIGVQLFKGT-----FFLCNDLSKMTEAECRGEYIHYEDGDPTKPV 2949
+I L+ + ++AIIG++LFKG +F+ D+ E E E +
Sbjct: 198 HIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENE--------EPSPCARTG 249
Query: 2950 SKKRVWSNND-------------FNFDNVGDAMISLFVVSTFEG---------------W 3045
S +R N +FDN G +M++++ T EG W
Sbjct: 250 SGRRCTINGSECRGGCPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEW 309
Query: 3046 PQLLYVAID-------------------SNEEDKGPIHNSRQAVALXXXXXXXXXXXXXX 3168
P + +V + + E +K + Q +
Sbjct: 310 PWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLDEDLRGYMSW 369
Query: 3169 XXXXGFVIVTFQNEGEREYENCELDKNQ-------RKCIEFALKAKPHRRYIPRNRL-QY 3324
+ V EG+ + D K I+F R + NR+ ++
Sbjct: 370 ITQGEVMDVEDFREGKLSLDEGGSDTESLYEIAGLNKIIQFI------RHWRQWNRIFRW 423
Query: 3325 RVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKI 3504
+ V S+ F +++ LI+ +NT+S+A +H+ D+ N + +F E ++K+
Sbjct: 424 KCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTTEMLMKM 483
Query: 3505 VALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSR 3684
L + Y +N FD VV ++I + G + I+ R R++R+ K+
Sbjct: 484 YGLGLRQYFMSIFNRFDCFVVCSGILEILL--VESGAMTPLGISVLRCIRLLRIFKITKY 541
Query: 3685 GEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSF 3864
+ L+ + + S +++ + LL+ L I+ ++GMQ FG + T + R +NF +F
Sbjct: 542 WTSLSNLVASLLNSIRSIASLLLLLFLFIVIFRLLGMQLFGGRYDFEDTEV-RRSNFDNF 600
Query: 3865 PAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP----- 4029
P A++ +F+ TGE W +M N +YP
Sbjct: 601 PQALISVFQVLTGEDWTSMM----------------------YNGIMAYRGPSYPGMLVC 638
Query: 4030 -YFISFFMLCSFLVINLFVAVIMDN 4101
YFI F+ +++++N+F+A+ +DN
Sbjct: 639 IYFIILFVCGNYILLNVFLAIAVDN 663
Score = 108 bits (270), Expect = 1e-21
Identities = 97/340 (28%), Positives = 156/340 (45%), Gaps = 9/340 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V N IR LC IV F IL I + AL
Sbjct: 757 RPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAAL 816
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P A +N +L+ + F VFT+E VLK+ G H ++ RN +N+LD +
Sbjct: 817 AAEDPIRADSM--RNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLL 874
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S L +I VK LR RVLRPLR ++ L+ + AI + +I
Sbjct: 875 VVAVSLISMGLESSAIS--VVKILRVLRVLRPLRAINRAKGLKCMFVAI----STIGNIV 928
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLT 855
L+ + ++A IG++LF GK C D L++ C G + + D +
Sbjct: 929 LVTTLLQFMFACIGVQLFKGKFF-RCTD-----LSKMTEEEC----RGYYYVYKDGDPM- 977
Query: 856 NMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDA----VG- 1020
+ +R + W + +FDN AM+++F + EGW ++Y D+ VG
Sbjct: 978 QIELR-----HREWV---HSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGP 1029
Query: 1021 ----REWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKERE 1128
R I+F+ +IL +FF++N+ +G + F ++ E
Sbjct: 1030 IYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGE 1069
Score = 90.5 bits (223), Expect = 4e-16
Identities = 80/336 (23%), Positives = 140/336 (40%), Gaps = 39/336 (11%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP + IV FE+L+ +I N I L + Q Y S+ N + + + F ++F
Sbjct: 1101 NPYQYQVWYIVTSSYFEYLMFALIMLNTICLGM-QHY--NQSEQMNHISDILNVAFTIIF 1157
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKM-----SIQGF----- 552
T+E +LK++A F Y N WN+ DF+IV+ ++ ILS++ S G
Sbjct: 1158 TLEMILKLMA----FKARGYFGNPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGG 1213
Query: 553 -------DVKA------LRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFV 693
D A R FRV+R ++L+S ++ +L +++ L ++ALL++ +
Sbjct: 1214 GCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVML 1273
Query: 694 ILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRW 873
IYA+IG+++F G++A D T
Sbjct: 1274 FFIYAVIGMQMF-------------GKIALVDGTQI------------------------ 1296
Query: 874 ECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVN--------------- 1008
N NF F A+L +F+C + E W +++ +
Sbjct: 1297 ------------NRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGE 1344
Query: 1009 -DAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
G + + YF++ +L +F V+NL + V+ F
Sbjct: 1345 EYTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNF 1380
Score = 75.1 bits (183), Expect = 2e-11
Identities = 58/247 (23%), Positives = 99/247 (39%), Gaps = 34/247 (13%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HY QSE ++H + N+ F I+F++EM+LK+ + Y + +N FD +VI SI++
Sbjct: 1134 QHYNQSEQMNHISDILNVAFTIIFTLEMILKLMAFKARGYFGNPWNVFDFLIVIGSIIDV 1193
Query: 1657 VLVYFDLM----------------------KPLGVSVLRSARLLRIFKVTKYWTXXXXXX 1770
+L D + + R R++R+ K+
Sbjct: 1194 ILSEIDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLL 1253
Query: 1771 XXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVF 1950
GMQ+FG + Q NF TF QA+L +F
Sbjct: 1254 WTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLF 1313
Query: 1951 QILTGEDWNTVMY----------HGIESFGGVGTLGVIVCIYYIVLF--ICGNYILLNVF 2094
+ TGE W ++ + G T G YY + F +C ++++N+F
Sbjct: 1314 RCATGEAWQEILLACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCA-FLVINLF 1372
Query: 2095 LAIAVDN 2115
+A+ +DN
Sbjct: 1373 VAVIMDN 1379
Score = 73.6 bits (179), Expect = 5e-11
Identities = 68/309 (22%), Positives = 127/309 (41%), Gaps = 57/309 (18%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDV----FNLIFTGVFAFEAVLKIVA-- 3510
+ FE +I L I N V+LA + P + L++ F VF+ EA +KI+A
Sbjct: 51 KPFETIILLTIFANCVALAV-YLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYG 109
Query: 3511 --LNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNL---------ISINFFRLFRV 3657
+ Y+ WNV D +V + ++N ++ + + R FRV
Sbjct: 110 FLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRV 169
Query: 3658 MRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GK-------V 3813
+R ++L+S ++ +L + K+ L ++ALL++ + IYA+IG++ F GK +
Sbjct: 170 LRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFI 229
Query: 3814 ALDDSTSI--------------------------------HRNNNFHSFPAAILVLFRSA 3897
D ++ H +F +F ++L +++
Sbjct: 230 GTDIVATVENEEPSPCARTGSGRRCTINGSECRGGCPGPNHGITHFDNFGFSMLTVYQCI 289
Query: 3898 TGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINL 4077
T E W D++ +D GN + + YF++ +L SF ++NL
Sbjct: 290 TMEGWTDVLYWVNDA---------------------IGNEWPWIYFVTLILLGSFFILNL 328
Query: 4078 FVAVIMDNF 4104
+ V+ F
Sbjct: 329 VLGVLSGEF 337
Score = 42.7 bits (99), Expect = 0.10
Identities = 48/245 (19%), Positives = 98/245 (39%), Gaps = 38/245 (15%)
Frame = +1
Query: 1489 QSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEF 1656
+++ L HF ++ F +F++E++LKM + G ++ + FN D VV S++
Sbjct: 828 RNQILKHF----DIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISM 883
Query: 1657 VLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1836
L + +SV++ R+LR+ + +
Sbjct: 884 GL------ESSAISVVKILRVLRVLRPLRA-INRAKGLKCMFVAISTIGNIVLVTTLLQF 936
Query: 1837 XXXXXGMQVFGGKF----------------------NFNPQQPKPRA--------NFDTF 1926
G+Q+F GKF + +P Q + R +FD
Sbjct: 937 MFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHREWVHSDFHFDNV 996
Query: 1927 VQALLTVFQILTGEDWNTVMYHGIES----FGGVGTLGVIVCIYYIVLFICGNYILLNVF 2094
+ A++++F + T E W ++Y I+S G + V + I++I+ I + ++N+F
Sbjct: 997 LSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIF 1056
Query: 2095 LAIAV 2109
+ +
Sbjct: 1057 VGFVI 1061
>gi|50761288|ref|XP_419259.1| PREDICTED: similar to Voltage-dependent
L-type calcium channel alpha-1S subunit (Voltage-gated
calcium channel alpha subunit Cav1.1) (Calcium channel, L
type, alpha-1 polypeptide, isoform 3, skeletal muscle)
[Gallus gallus]
Length = 1860
Score = 935 bits (2416), Expect = 0.0
Identities = 491/872 (56%), Positives = 601/872 (68%), Gaps = 57/872 (6%)
Frame = +1
Query: 2260 SARPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSA 2439
S RPR ++E+ P+P+ASS FI S TN FR+ C+ +VN ++FTN +L IL+SS
Sbjct: 780 SPRPRPLAELQLKEKAVPMPEASSFFIFSPTNKFRMLCHRIVNATWFTNFILLFILLSSI 839
Query: 2440 MLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDIL 2619
LAAEDP++A S RN IL YFD FTSVFTVEI LK+ +G HKGSFCR++ I
Sbjct: 840 SLAAEDPIRAESFRNQILGYFDIGFTSVFTVEIVLKMTGYGAFLHKGSFCRSS----TIS 895
Query: 2620 VVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLV 2799
VV + VLR AINRAKGLKHVVQCV VA+KTIGNI++V
Sbjct: 896 VVKILRVLRVLRP-----------------LRAINRAKGLKHVVQCVFVAIKTIGNIVVV 938
Query: 2800 TFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNND 2979
T +LQFMFA IGVQLFKG F+ C D SK+TE ECRG +I+Y DGDPT+ K+RVW +N
Sbjct: 939 TTLLQFMFACIGVQLFKGKFYSCTDPSKLTEKECRGHFINYVDGDPTQIELKERVWFHNA 998
Query: 2980 FNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXX 3159
F+F+NV AM+SLF VSTFEGWP+LLY AID+N+E+KGPI+N R +A+
Sbjct: 999 FHFNNVLSAMMSLFTVSTFEGWPELLYRAIDTNDENKGPIYNYRVEIAMFFIIYIILIAF 1058
Query: 3160 XXXXXXXGFVIVTFQNEGEREYENCELDKNQ----------------------------- 3252
GFVIVTFQ +GE EY+NCELDKNQ
Sbjct: 1059 FMMNIFVGFVIVTFQEQGESEYKNCELDKNQGYRLAAMGSCAVTSSAGSVPVPLALPVQL 1118
Query: 3253 ----------RKCIEFALKAKPHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSL 3402
R+C+++ALKA+P RRYIP+N QY++W+ VTS FEY++F +I++NT+ L
Sbjct: 1119 RVVTLPHSPQRQCVQYALKARPLRRYIPKNPYQYQIWYVVTSSYFEYLMFFLIMLNTICL 1178
Query: 3403 ACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFI 3582
+HY S D+ N+ FT +F E +LK++A K Y D WNVFD L+V+GS I
Sbjct: 1179 GMQHYNQSAEMNHVSDILNVAFTVLFTLEMILKLMAFKAKGYFGDPWNVFDFLIVIGSII 1238
Query: 3583 DITYGK------------------LNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLL 3708
D+ + L+P + +SI FFRLFRVMRLVKLLSRGEG+RTLL
Sbjct: 1239 DVILSEIDVSVRLLGQRVSRGASVLDPDDNSRVSITFFRLFRVMRLVKLLSRGEGVRTLL 1298
Query: 3709 WTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLF 3888
WTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+A+ D T I+RNNNF +FP A+L+LF
Sbjct: 1299 WTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIAMVDGTQINRNNNFQTFPQAVLLLF 1358
Query: 3889 RSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLV 4068
R ATGEAWQ+I+L CS + RCDP SD Y +G E CG FAY YFISF+MLC+FL+
Sbjct: 1359 RCATGEAWQEILLDCSYGK--RCDPESD-YAEG--EEYTCGTGFAYFYFISFYMLCAFLI 1413
Query: 4069 INLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPP 4248
INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+W+EYDP+AKGRIKHLDVVTLLR+I PP
Sbjct: 1414 INLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPP 1473
Query: 4249 LGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNIDEANEQLRS 4428
LGFGK CPHR+ACKRLV MNMPLNSDGTV FNATLFALVRT LKI TEGN ++ANE+LR+
Sbjct: 1474 LGFGKFCPHRVACKRLVCMNMPLNSDGTVTFNATLFALVRTALKIKTEGNFEQANEELRT 1533
Query: 4429 AIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEMEAKGVLPAQ 4608
IK+IWKRT LLD+V+PP G +D+VTVGKFYATFLIQ++FR+F KR+E E G+
Sbjct: 1534 IIKKIWKRTSMKLLDQVIPPIG-DDEVTVGKFYATFLIQEHFRKFMKRQE-ENYGI---- 1587
Query: 4609 TPQAMALQAGLRTLHEIGPELKRAISGNLETD 4704
E PE+ RAISG+L +
Sbjct: 1588 -------------EEEAAPEIHRAISGDLTAE 1606
Score = 662 bits (1708), Expect = 0.0
Identities = 349/681 (51%), Positives = 437/681 (63%), Gaps = 40/681 (5%)
Frame = +1
Query: 223 NPIRKLCISIVEWK-----PFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYV 387
NP+RK CISIVEWK PFE +IL I ANC+ALAIYQP P D++ N+ LE +EYV
Sbjct: 41 NPLRKACISIVEWKYPSDGPFEIIILLTIFANCVALAIYQPMPEDDTNVANSSLEKLEYV 100
Query: 388 FIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQ------- 546
F++ F IE +LKI+A GF+FH AYLRN WN+LDF IV +GLV+ L +++ +
Sbjct: 101 FLIFFAIEAMLKIIAYGFLFHTDAYLRNGWNVLDFSIVSLGLVTMTLEQINAKEGGSLGG 160
Query: 547 --GFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGL 720
GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+I++AM+PLLHIALLVLF+I+IYAI+G
Sbjct: 161 KGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFMIIIYAIVGQ 220
Query: 721 ELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTT-- 894
ELF GK+H TC L + P PC T G CS N T
Sbjct: 221 ELFKGKMHKTCY-----YLGTEKPAPCTTSGHGR-----------------HCSINGTEC 258
Query: 895 ---WPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILG 1065
WPGPNNGIT+FDNFG AMLTV+QC+++EGWT+V+YWVNDA+G EWPWIYFV+L++LG
Sbjct: 259 RGGWPGPNNGITHFDNFGFAMLTVYQCITMEGWTEVLYWVNDAIGNEWPWIYFVSLILLG 318
Query: 1066 SFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIE---- 1233
SFFVLNLVLGVLSGEF+KEREKA++RG FQK REKQQL ED+KGY+DWIT AE ++
Sbjct: 319 SFFVLNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLGEDMKGYMDWITHAEVMDSDRA 378
Query: 1234 ------PVNEDEQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXX 1395
P++E E E + + +KW ++ + N
Sbjct: 379 RGEGMMPLDEGGSETESLYEIEGM----------------NKWILYFRQWRRWNRMFRRK 422
Query: 1396 XXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMY 1575
+VKS+ FYW SEH+ Q EWL Q AN + LF EMLLKMY
Sbjct: 423 CRDVVKSKFFYWLVILLVALNTLSIASEHHFQPEWLTIVQDNANRVLLALFVAEMLLKMY 482
Query: 1576 SLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTX 1755
+LG Y S FNRFDCFVV + +L+ +LV + PLG+SVLR RLLRIFK+T+YWT
Sbjct: 483 ALGLRQYFMSLFNRFDCFVVCAGVLKIILVELSTLSPLGISVLRCIRLLRIFKITRYWTS 542
Query: 1756 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQA 1935
GMQ+FGG ++F + + R+ FD F QA
Sbjct: 543 LSNLVASLLNSVRSIASLLLLLFLFIIVFALLGMQLFGGMYDFEDMEVR-RSTFDNFPQA 601
Query: 1936 LLTVFQ-----------ILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYIL 2082
L++VFQ ILTGEDWN++MY+GI ++GG G++VCIY+I+LF+CGNYIL
Sbjct: 602 LISVFQVWGCKKQGKGDILTGEDWNSIMYNGIMAYGGPSFPGMLVCIYFIILFVCGNYIL 661
Query: 2083 LNVFLAIAVDNLADADSLTNA 2145
LNVFLAIAVDNLA+A+SLT+A
Sbjct: 662 LNVFLAIAVDNLAEAESLTSA 682
Score = 93.2 bits (230), Expect = 6e-17
Identities = 87/340 (25%), Positives = 147/340 (42%), Gaps = 9/340 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V N R LC IV F IL I + I+L
Sbjct: 782 RPRPLAELQLKEKAVPMPEASSFFIFSPTNKFRMLCHRIVNATWFTNFILLFILLSSISL 841
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P A+ ++N +L + F VFT+E VLK+ G H ++ R+
Sbjct: 842 AAEDPIRAES--FRNQILGYFDIGFTSVFTVEIVLKMTGYGAFLHKGSFCRS-------- 891
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
S +S+ VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 892 -----------STISV----VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIKTIGNIV 936
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLT 855
++ + ++A IG++LF GK +S C DP+ +L +K + G D T
Sbjct: 937 VVTTLLQFMFACIGVQLFKGKFYS-CTDPS--KLTEK-------ECRGHFINYVDGDP-T 985
Query: 856 NMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPW 1035
+ ++ W + +F+N AM+++F + EGW +++Y D
Sbjct: 986 QIELK-----ERVW---FHNAFHFNNVLSAMMSLFTVSTFEGWPELLYRAIDTNDENKGP 1037
Query: 1036 IY---------FVTLVILGSFFVLNLVLGVLSGEFSKERE 1128
IY F+ +IL +FF++N+ +G + F ++ E
Sbjct: 1038 IYNYRVEIAMFFIIYIILIAFFMMNIFVGFVIVTFQEQGE 1077
Score = 91.3 bits (225), Expect = 2e-16
Identities = 76/334 (22%), Positives = 139/334 (40%), Gaps = 37/334 (11%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP + +V FE+L+ F+I N I L + Q Y S N + + + F V+F
Sbjct: 1148 NPYQYQIWYVVTSSYFEYLMFFLIMLNTICLGM-QHY--NQSAEMNHVSDILNVAFTVLF 1204
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQ------------ 546
T+E +LK++A F Y + WN+ DF+IV+ ++ ILS++ +
Sbjct: 1205 TLEMILKLMA----FKAKGYFGDPWNVFDFLIVIGSIIDVILSEIDVSVRLLGQRVSRGA 1260
Query: 547 ---------GFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVIL 699
+ R FRV+R ++L+S ++ +L +++ L ++ALL++ +
Sbjct: 1261 SVLDPDDNSRVSITFFRLFRVMRLVKLLSRGEGVRTLLWTFIKSFQALPYVALLIVMLFF 1320
Query: 700 IYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWEC 879
IYA+IG+++F G++A D T
Sbjct: 1321 IYAVIGMQMF-------------GKIAMVDGTQI-------------------------- 1341
Query: 880 SSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVM--------------YWVND-- 1011
N NF F A+L +F+C + E W +++ Y +
Sbjct: 1342 ----------NRNNNFQTFPQAVLLLFRCATGEAWQEILLDCSYGKRCDPESDYAEGEEY 1391
Query: 1012 AVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
G + + YF++ +L +F ++NL + V+ F
Sbjct: 1392 TCGTGFAYFYFISFYMLCAFLIINLFVAVIMDNF 1425
Score = 90.9 bits (224), Expect = 3e-16
Identities = 64/271 (23%), Positives = 125/271 (45%), Gaps = 17/271 (6%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S+ F +++ L++ +NT+S+A +H+ D N + +F E +LK+ AL
Sbjct: 427 VKSKFFYWLVILLVALNTLSIASEHHFQPEWLTIVQDNANRVLLALFVAEMLLKMYALGL 486
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD VV + I +L+ + + I+ R R++R+ K+ +
Sbjct: 487 RQYFMSLFNRFDCFVVCAGVLKIILVELST--LSPLGISVLRCIRLLRIFKITRYWTSLS 544
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAIL 3879
L+ + + S +++ + LL+ L ++A++GMQ FG + + + R + F +FP A++
Sbjct: 545 NLVASLLNSVRSIASLLLLLFLFIIVFALLGMQLFGGMYDFEDMEV-RRSTFDNFPQALI 603
Query: 3880 VLFR-----------SATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAY 4026
+F+ TGE W IM N ++
Sbjct: 604 SVFQVWGCKKQGKGDILTGEDWNSIM----------------------YNGIMAYGGPSF 641
Query: 4027 P------YFISFFMLCSFLVINLFVAVIMDN 4101
P YFI F+ +++++N+F+A+ +DN
Sbjct: 642 PGMLVCIYFIILFVCGNYILLNVFLAIAVDN 672
Score = 89.4 bits (220), Expect = 9e-16
Identities = 74/303 (24%), Positives = 130/303 (42%), Gaps = 45/303 (14%)
Frame = +1
Query: 3331 WWFVTSRAFEYVIFLIIVMNTVSLACKH---YPSSRGFEDFLDVFNLIFTGVFAFEAVLK 3501
W + + FE +I L I N V+LA + L+ +F FA EA+LK
Sbjct: 53 WKYPSDGPFEIIILLTIFANCVALAIYQPMPEDDTNVANSSLEKLEYVFLIFFAIEAMLK 112
Query: 3502 IVA----LNPKNYISDRWNVFDLLVVVGSFIDITYGKLNP------GGTNLISINFFRLF 3651
I+A + Y+ + WNV D +V + +T ++N GG + R F
Sbjct: 113 IIAYGFLFHTDAYLRNGWNVLDFSIVSLGLVTMTLEQINAKEGGSLGGKGGFDVKALRAF 172
Query: 3652 RVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKV----- 3813
RV+R ++L+S ++ +L + +K+ L ++ALL++ + IYA++G + F GK+
Sbjct: 173 RVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFMIIIYAIVGQELFKGKMHKTCY 232
Query: 3814 ------ALDDSTSIHRNN--------------------NFHSFPAAILVLFRSATGEAWQ 3915
+TS H + +F +F A+L +++ T E W
Sbjct: 233 YLGTEKPAPCTTSGHGRHCSINGTECRGGWPGPNNGITHFDNFGFAMLTVYQCITMEGWT 292
Query: 3916 DIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIM 4095
+++ +D GN + + YF+S +L SF V+NL + V+
Sbjct: 293 EVLYWVND---------------------AIGNEWPWIYFVSLILLGSFFVLNLVLGVLS 331
Query: 4096 DNF 4104
F
Sbjct: 332 GEF 334
Score = 86.3 bits (212), Expect = 8e-15
Identities = 74/285 (25%), Positives = 120/285 (41%), Gaps = 29/285 (10%)
Frame = +1
Query: 2308 KPIPKAS-----SLFILSHTNSFRVFCNMVVNHSY-----FTNAVLFCILVSSAMLAAED 2457
KP+P + +LF L+ N R C +V Y F +L I + LA
Sbjct: 21 KPVPPVAPRPPRALFCLTLQNPLRKACISIVEWKYPSDGPFEIIILLTIFANCVALAIYQ 80
Query: 2458 PLQANSTR--NMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAV 2631
P+ + T N L +Y F F +E LK+I +G +FH ++ RN +N+LD +V++
Sbjct: 81 PMPEDDTNVANSSLEKLEYVFLIFFAIEAMLKIIAYGFLFHTDAYLRNGWNVLDFSIVSL 140
Query: 2632 SLTSFVLR----TDAMSXXXXXXXXXXXXXXXAINR-------AKGLKHVVQCVIVAVKT 2778
L + L + S + R L+ V+ +I A+
Sbjct: 141 GLVTMTLEQINAKEGGSLGGKGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVP 200
Query: 2779 IGNIMLVTFMLQFMFAIIGVQLFKGTFF-LCNDLSKMTEAEC--RGEYIHYEDGDPTKPV 2949
+ +I L+ + ++AI+G +LFKG C L A C G H
Sbjct: 201 LLHIALLVLFMIIIYAIVGQELFKGKMHKTCYYLGTEKPAPCTTSGHGRHCS----INGT 256
Query: 2950 SKKRVW---SNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
+ W +N +FDN G AM++++ T EGW ++LY D+
Sbjct: 257 ECRGGWPGPNNGITHFDNFGFAMLTVYQCITMEGWTEVLYWVNDA 301
Score = 77.0 bits (188), Expect = 5e-12
Identities = 61/248 (24%), Positives = 100/248 (39%), Gaps = 35/248 (14%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HY QS ++H + N+ F +LF++EM+LK+ + Y +N FD +VI SI++
Sbjct: 1181 QHYNQSAEMNHVSDILNVAFTVLFTLEMILKLMAFKAKGYFGDPWNVFDFLIVIGSIIDV 1240
Query: 1657 VLVYFDLMKPL-------GVSVL-------------RSARLLRIFKVTKYWTXXXXXXXX 1776
+L D+ L G SVL R R++R+ K+
Sbjct: 1241 ILSEIDVSVRLLGQRVSRGASVLDPDDNSRVSITFFRLFRVMRLVKLLSRGEGVRTLLWT 1300
Query: 1777 XXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQI 1956
GMQ+FG + Q NF TF QA+L +F+
Sbjct: 1301 FIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIAMVDGTQINRNNNFQTFPQAVLLLFRC 1360
Query: 1957 LTGEDWNTVMY---------------HGIESFGGVGTLGVIVCIYYIVLFICGNYILLNV 2091
TGE W ++ G E G G Y+I ++ ++++N+
Sbjct: 1361 ATGEAWQEILLDCSYGKRCDPESDYAEGEEYTCGTG----FAYFYFISFYMLCAFLIINL 1416
Query: 2092 FLAIAVDN 2115
F+A+ +DN
Sbjct: 1417 FVAVIMDN 1424
Score = 67.4 bits (163), Expect = 4e-09
Identities = 71/341 (20%), Positives = 138/341 (39%), Gaps = 39/341 (11%)
Frame = +1
Query: 3199 FQNEGEREYENCELDKNQRKCIEFALKAK----PHRR----YIPRNRLQYRVWWFVTSRA 3354
F + E + L R E LK K P + P N+ + V +
Sbjct: 766 FPGDDEEDEPEIPLSPRPRPLAELQLKEKAVPMPEASSFFIFSPTNKFRMLCHRIVNATW 825
Query: 3355 FEYVIFLIIVMNTVSLACKHYPSSRGFED-FLDVFNLIFTGVFAFEAVLKIVALNPKNYI 3531
F I L I+++++SLA + + F + L F++ FT VF E VLK+
Sbjct: 826 FTNFILLFILLSSISLAAEDPIRAESFRNQILGYFDIGFTSVFTVEIVLKMTG------- 878
Query: 3532 SDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLW 3711
+ + GSF + + + R+ RV+R ++ ++R +G++ ++
Sbjct: 879 ------YGAFLHKGSFC---------RSSTISVVKILRVLRVLRPLRAINRAKGLKHVVQ 923
Query: 3712 TFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GK-------------------------- 3810
+ + + + ++ LL F++A IG+Q F GK
Sbjct: 924 CVFVAIKTIGNIVVVTTLLQFMFACIGVQLFKGKFYSCTDPSKLTEKECRGHFINYVDGD 983
Query: 3811 ---VALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYH 3981
+ L + H +F++ +A++ LF +T E W +++ D ++D +
Sbjct: 984 PTQIELKERVWFHNAFHFNNVLSAMMSLFTVSTFEGWPELLYRAID---------TNDEN 1034
Query: 3982 KGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
KG + R +FI + +L +F ++N+FV ++ F
Sbjct: 1035 KGPIYNYRVE---IAMFFIIYIILIAFFMMNIFVGFVIVTF 1072
Score = 44.3 bits (103), Expect = 0.035
Identities = 36/170 (21%), Positives = 74/170 (43%), Gaps = 3/170 (1%)
Frame = +1
Query: 2359 FRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEI 2538
FR C VV +F V+ + +++ +A+E Q ++ + + ++F E+
Sbjct: 419 FRRKCRDVVKSKFFYWLVILLVALNTLSIASEHHFQPEWL-TIVQDNANRVLLALFVAEM 477
Query: 2539 TLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL---RTDAMSXXXXXXXXXXXXX 2709
LK+ GL + + FN D VV + +L T +
Sbjct: 478 LLKMYALGL----RQYFMSLFNRFDCFVVCAGVLKIILVELSTLSPLGISVLRCIRLLRI 533
Query: 2710 XXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTF 2859
L ++V ++ +V++I +++L+ F+ +FA++G+QLF G +
Sbjct: 534 FKITRYWTSLSNLVASLLNSVRSIASLLLLLFLFIIVFALLGMQLFGGMY 583
>gi|31236903|ref|XP_319498.1| ENSANGP00000002951 [Anopheles gambiae]
gi|21302440|gb|EAA14585.1| ENSANGP00000002951 [Anopheles gambiae str.
PEST]
Length = 862
Score = 928 bits (2399), Expect = 0.0
Identities = 459/692 (66%), Positives = 545/692 (78%), Gaps = 9/692 (1%)
Frame = +1
Query: 2269 PRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLA 2448
PRR+S + P ++LFILS+TN FR FC+ + NH+ F N +L CI++SS MLA
Sbjct: 175 PRRLSHIGLKVKKHREPPKNALFILSNTNRFRQFCHWLCNHTVFGNIILLCIMLSSVMLA 234
Query: 2449 AEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVA 2628
AEDPL ANS RN ILN FD+FFT+VF +E+ LKVI +G + HKG+FCR+AFNLLD+LVV+
Sbjct: 235 AEDPLNANSERNQILNKFDFFFTAVFAIELILKVIAYGFILHKGAFCRSAFNLLDLLVVS 294
Query: 2629 VSLTSFVLR---TDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLV 2799
VSL S + R + +S AINRAKGLKHVVQCVIVAVKTIGNI+LV
Sbjct: 295 VSLVSMLFRQVISGTISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLV 354
Query: 2800 TFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNND 2979
TF+LQFMFA+IGVQLFKG FF C+D SK EAEC G Y+ +EDG+ KPVSK+R WSNN
Sbjct: 355 TFLLQFMFAVIGVQLFKGKFFSCSDRSKYEEAECHGTYLVFEDGNVDKPVSKEREWSNNR 414
Query: 2980 FNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXX 3159
F+FD+V AM++LF VSTFEGWP LLYV+IDS+ E+ GPI+N R VA
Sbjct: 415 FHFDDVQKAMLTLFTVSTFEGWPSLLYVSIDSHTENFGPIYNYRPLVATYYIIYIIVIAF 474
Query: 3160 XXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRN-RLQYRVWW 3336
GFVIVTFQNEGE+EY+NC+LDKNQR CIEFALKAKP RRYIP + R+QY+VWW
Sbjct: 475 FMVNIFVGFVIVTFQNEGEQEYKNCDLDKNQRNCIEFALKAKPVRRYIPNDDRIQYKVWW 534
Query: 3337 FVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALN 3516
FVTS+ FEY IF++I+MNT++L+ K Y + + ++LD NL+FT VFA E V K+ A
Sbjct: 535 FVTSQLFEYTIFILIMMNTITLSMKFYRQPQPYTEWLDFLNLLFTAVFALEFVFKLAAFR 594
Query: 3517 PKNYISDRWNVFDLLVVVGSFIDITYGKLNP-----GGTNLISINFFRLFRVMRLVKLLS 3681
+NY D WNVFD ++V+GSFIDI Y ++ G + +ISINFFRLFRVMRL+KLL+
Sbjct: 595 FQNYFGDAWNVFDFIIVLGSFIDIVYSEVTTSSGTKGASTIISINFFRLFRVMRLIKLLA 654
Query: 3682 RGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHS 3861
RGEGIRTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FG++ALDD T+IHRNNNF +
Sbjct: 655 RGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGRIALDDDTAIHRNNNFQT 714
Query: 3862 FPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFIS 4041
FP AILVLFRSATGEAWQDIML CS RE+VRCD S+D ++ CG+NFA+PYFIS
Sbjct: 715 FPQAILVLFRSATGEAWQDIMLDCSAREEVRCDENSEDKE----SKEGCGSNFAFPYFIS 770
Query: 4042 FFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVV 4221
F++LCSFL+INLFVAVIMDNFDYLTRDWSILGPHHL+EFVRLWSEYDPDAKGRIKHLDVV
Sbjct: 771 FYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFVRLWSEYDPDAKGRIKHLDVV 830
Query: 4222 TLLRKISPPLGFGKLCPHRLACKRLVSMNMPL 4317
TLLRKISPPLGFGKLCPHR+ACKRLVSMNMPL
Sbjct: 831 TLLRKISPPLGFGKLCPHRVACKRLVSMNMPL 862
Score = 160 bits (404), Expect = 4e-37
Identities = 155/666 (23%), Positives = 274/666 (40%), Gaps = 35/666 (5%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
N R+ C + F +IL I + + LA P A +N +L ++ F VF
Sbjct: 203 NRFRQFCHWLCNHTVFGNIILLCIMLSSVMLAAEDPLNANSE--RNQILNKFDFFFTAVF 260
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKALRAF 576
IE +LK++A GF+ H A+ R+A+N+LD ++V + LVS +L + I G VK LR
Sbjct: 261 AIELILKVIAYGFILHKGAFCRSAFNLLDLLVVSVSLVS-MLFRQVISGTISVVKILRVL 319
Query: 577 RVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI 756
RVLRPLR ++ L+ V+ ++ A+ + +I L+ + ++A+IG++LF GK S
Sbjct: 320 RVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTFLLQFMFAVIGVQLFKGKFFS--- 376
Query: 757 DPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMG-VRWECSSNTTWPGPNNGITNFDN 933
C ++ +C + + G V S W +N +FD+
Sbjct: 377 --------------CSDRSKYEEAECHGTYLVFEDGNVDKPVSKEREW---SNNRFHFDD 419
Query: 934 FGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWI---------YFVTLVILGSFFVLNL 1086
AMLT+F + EGW ++Y D+ + I Y++ +I+ +FF++N+
Sbjct: 420 VQKAMLTLFTVSTFEGWPSLLYVSIDSHTENFGPIYNYRPLVATYYIIYIIVIAFFMVNI 479
Query: 1087 VLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEP 1266
+G + F E E Q+++ L+++ + +++ +A +PV D+
Sbjct: 480 FVGFVIVTFQNEGE--------QEYK-NCDLDKNQRNCIEFALKA---KPVRRYIPNDDR 527
Query: 1267 VAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXX 1446
+ W +L + + S FY
Sbjct: 528 IQY--------------------KVWWFVTSQLFEYTIFILIMMNTITLSMKFY------ 561
Query: 1447 XXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDC 1626
+ +EWLD NL F +F++E + K+ + F Y +N FD
Sbjct: 562 ---------RQPQPYTEWLD----FLNLLFTAVFALEFVFKLAAFRFQNYFGDAWNVFDF 608
Query: 1627 FVVISSILEFVLVYFDLMKPLG---------VSVLRSARLLRIFKVTKYWTXXXXXXXXX 1779
+V+ S ++ +VY ++ G ++ R R++R+ K+
Sbjct: 609 IIVLGSFID--IVYSEVTTSSGTKGASTIISINFFRLFRVMRLIKLLARGEGIRTLLWTF 666
Query: 1780 XXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQIL 1959
GMQVFG + NF TF QA+L +F+
Sbjct: 667 IKSFQALPYVALLIVMLFFIYAVIGMQVFGRIALDDDTAIHRNNNFQTFPQAILVLFRSA 726
Query: 1960 TGEDWNTVMY--------------HGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFL 2097
TGE W +M ES G G+ Y+I ++ +++++N+F+
Sbjct: 727 TGEAWQDIMLDCSAREEVRCDENSEDKESKEGCGS--NFAFPYFISFYVLCSFLIINLFV 784
Query: 2098 AIAVDN 2115
A+ +DN
Sbjct: 785 AVIMDN 790
Score = 150 bits (378), Expect = 4e-34
Identities = 69/93 (74%), Positives = 82/93 (87%)
Frame = +1
Query: 1861 VFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVC 2040
VFGG+F FN KPR+NFD+FVQ+LLTVFQILTGEDWN VMY GI+++GGV + G++
Sbjct: 1 VFGGRFIFNSMDNKPRSNFDSFVQSLLTVFQILTGEDWNAVMYDGIQAYGGVASFGILAS 60
Query: 2041 IYYIVLFICGNYILLNVFLAIAVDNLADADSLT 2139
IY+I+LFICGNYILLNVFLAIAVDNLADA+SLT
Sbjct: 61 IYFIILFICGNYILLNVFLAIAVDNLADAESLT 93
Score = 87.4 bits (215), Expect = 4e-15
Identities = 80/357 (22%), Positives = 146/357 (40%), Gaps = 34/357 (9%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIY---QPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMG 438
FE+ I +I N I L++ QP P + L+ + +F VF +E V K+ A
Sbjct: 541 FEYTIFILIMMNTITLSMKFYRQPQPYTE------WLDFLNLLFTAVFALEFVFKLAAFR 594
Query: 439 FMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--------FDVKALRAFRVLRPL 594
F Y +AWN+ DFIIV+ + + S+++ + R FRV+R +
Sbjct: 595 FQ----NYFGDAWNVFDFIIVLGSFIDIVYSEVTTSSGTKGASTIISINFFRLFRVMRLI 650
Query: 595 RLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQ 774
+L++ ++ +L +++ L ++ALL++ + IYA+IG+++F G+
Sbjct: 651 KLLARGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-------------GR 697
Query: 775 LAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLT 954
+A D T + NF F A+L
Sbjct: 698 IALDDDTAIHRNN------------------------------------NFQTFPQAILV 721
Query: 955 VFQCVSLEGWTDVMYWVN-----------------DAVGREWPWIYFVTLVILGSFFVLN 1083
+F+ + E W D+M + + G + + YF++ +L SF ++N
Sbjct: 722 LFRSATGEAWQDIMLDCSAREEVRCDENSEDKESKEGCGSNFAFPYFISFYVLCSFLIIN 781
Query: 1084 LVLGVLSGEF---SKEREKARARGLFQKFREKQQLEEDLKG---YLDWITQAEDIEP 1236
L + V+ F +++ L + R + + D KG +LD +T I P
Sbjct: 782 LFVAVIMDNFDYLTRDWSILGPHHLDEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 838
Score = 47.8 bits (112), Expect = 0.003
Identities = 42/144 (29%), Positives = 66/144 (45%), Gaps = 24/144 (16%)
Frame = +1
Query: 907 NNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPW-----IYFVTLVILGSF 1071
N +NFD+F ++LTVFQ ++ E W VMY A G + IYF+ L I G++
Sbjct: 13 NKPRSNFDSFVQSLLTVFQILTGEDWNAVMYDGIQAYGGVASFGILASIYFIILFICGNY 72
Query: 1072 FVLNLVLGV----------LSGEFSKEREKARARGLFQKFR-----EKQQLEEDLKGYLD 1206
+LN+ L + L+ ++ L +K + EEDL G
Sbjct: 73 ILLNVFLAIAVDNLADAESLTAVEKEDGPDTELDNLTEKSENDLGGRDNEDEEDLNG--- 129
Query: 1207 WITQAEDIEPVNEDEQ----EDEP 1266
A++IE +N+D++ DEP
Sbjct: 130 ----ADEIEGLNDDDENFYKNDEP 149
Score = 36.2 bits (82), Expect = 9.4
Identities = 26/100 (26%), Positives = 45/100 (45%)
Frame = +1
Query: 3802 FGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYH 3981
FG + +S +NF SF ++L +F+ TGE W +M
Sbjct: 2 FGGRFIFNSMDNKPRSNFDSFVQSLLTVFQILTGEDWNAVMYDGIQA------------- 48
Query: 3982 KGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDN 4101
GG+ A YFI F+ +++++N+F+A+ +DN
Sbjct: 49 YGGVASF---GILASIYFIILFICGNYILLNVFLAIAVDN 85
>gi|2373389|dbj|BAA22091.1| voltage-dependent calcium channel alpha-1
subunit [Blattella germanica]
Length = 871
Score = 926 bits (2393), Expect = 0.0
Identities = 457/692 (66%), Positives = 546/692 (78%), Gaps = 5/692 (0%)
Frame = +1
Query: 2257 TSARPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSS 2436
++ARPR + + P + P+ S+ FI S+TN RVFC+ + NHSYF N +L CI++SS
Sbjct: 186 STARPRNVGDQPENND-SSTPEGSAFFIFSNTNRIRVFCHWLCNHSYFGNMILACIMISS 244
Query: 2437 AMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDI 2616
AMLAAE+PL+A + RN IL FD FFTSVFT+EI LK+I +G V H G+FCR+AFNLLD+
Sbjct: 245 AMLAAEEPLRAETPRNEILGKFDIFFTSVFTIEICLKMISYGFVLHDGAFCRSAFNLLDM 304
Query: 2617 LVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIML 2796
LVV VSL + +R A+S INRAKGLKHVVQCVIVAVKTIGNI+L
Sbjct: 305 LVVFVSLIAMFIRGSAISVIKILRVMRVLRPLRTINRAKGLKHVVQCVIVAVKTIGNIVL 364
Query: 2797 VTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNN 2976
VT ++QFMFA+IGVQLFKG FF C+D SKMTEAEC G Y+ ++DGD +P ++R W+ N
Sbjct: 365 VTCLVQFMFAVIGVQLFKGKFFRCSDGSKMTEAECHGTYLVFDDGDINQPEVEERRWTRN 424
Query: 2977 DFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXX 3156
F+FD+V AM++LF VSTFEGWP LLYV+IDS++ED+GPIHN R VA+
Sbjct: 425 RFHFDDVAKAMLTLFTVSTFEGWPGLLYVSIDSHDEDEGPIHNFRPIVAIFFIVYIIIIA 484
Query: 3157 XXXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWW 3336
GFVIVTFQNEGE+EY+NCELDKNQR CIEFALKAKP RRYIP++R+QY+VWW
Sbjct: 485 FFMVNIFVGFVIVTFQNEGEQEYKNCELDKNQRNCIEFALKAKPVRRYIPKHRIQYKVWW 544
Query: 3337 FVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALN 3516
FVTS+ FEY IF++I++NT++LA K Y + +EDFLDV N+IFT VFA E V K+ A
Sbjct: 545 FVTSQPFEYTIFILIMLNTITLAMKFYNQPKYYEDFLDVLNIIFTAVFAMEFVFKLAAFR 604
Query: 3517 PKNYISDRWNVFDLLVVVGSFIDITYGKLNPG-----GTNLISINFFRLFRVMRLVKLLS 3681
KNY + WNVFD ++V+GSFIDI Y ++N G+ +ISINFFRLFRVMRLVKLLS
Sbjct: 605 FKNYFGNAWNVFDFIIVLGSFIDIIYSEVNTPTRLKPGSGMISINFFRLFRVMRLVKLLS 664
Query: 3682 RGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHS 3861
RGEGIRTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+ALD T+IHRNNNF +
Sbjct: 665 RGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALDSGTAIHRNNNFQT 724
Query: 3862 FPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFIS 4041
FP A+L+LFRSATGEAWQDIML S R+ VRCD SD+ K CG++ A+PYFIS
Sbjct: 725 FPQAVLLLFRSATGEAWQDIMLDGSARDGVRCDSESDEKDK-----PICGSDMAFPYFIS 779
Query: 4042 FFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVV 4221
F++LCSFL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF+RLWSEYDPDAKGRIKHLDVV
Sbjct: 780 FYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVV 839
Query: 4222 TLLRKISPPLGFGKLCPHRLACKRLVSMNMPL 4317
TLLRKISPPLGFGKLCPHR+ACKRLVSMNMPL
Sbjct: 840 TLLRKISPPLGFGKLCPHRVACKRLVSMNMPL 871
Score = 151 bits (382), Expect = 2e-34
Identities = 69/93 (74%), Positives = 84/93 (90%)
Frame = +1
Query: 1861 VFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVC 2040
+FGGKF+FN KPR+NFD+F Q+LLTVFQILTGEDWN VMY GI+++GGV ++GV+ C
Sbjct: 1 LFGGKFDFNNTVDKPRSNFDSFWQSLLTVFQILTGEDWNAVMYVGIQAYGGVSSIGVLAC 60
Query: 2041 IYYIVLFICGNYILLNVFLAIAVDNLADADSLT 2139
+Y+I+LFICGNYILLNVFLAIAVDNLADA+SLT
Sbjct: 61 VYFIILFICGNYILLNVFLAIAVDNLADAESLT 93
Score = 114 bits (285), Expect = 3e-23
Identities = 88/312 (28%), Positives = 151/312 (48%), Gaps = 9/312 (2%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
N IR C + F +IL I + LA +P A+ +N +L + F VF
Sbjct: 217 NRIRVFCHWLCNHSYFGNMILACIMISSAMLAAEEPLRAETP--RNEILGKFDIFFTSVF 274
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
TIE LK+++ GF+ H A+ R+A+N+LD ++V + L++ + +I +K LR RV
Sbjct: 275 TIEICLKMISYGFVLHDGAFCRSAFNLLDMLVVFVSLIAMFIRGSAIS--VIKILRVMRV 332
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLR ++ L+ V+ ++ A+ + +I L+ V ++A+IG++LF GK C D
Sbjct: 333 LRPLRTINRAKGLKHVVQCVIVAVKTIGNIVLVTCLVQFMFAVIGVQLFKGKFF-RCSDG 391
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
+ A+ T D +G + + + RW +FD+
Sbjct: 392 SKMTEAECHGTYLVFD-DGDINQPEVEER------RW-----------TRNRFHFDDVAK 433
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDAVG---------REWPWIYFVTLVILGSFFVLNLVLG 1095
AMLT+F + EGW ++Y D+ R I+F+ +I+ +FF++N+ +G
Sbjct: 434 AMLTLFTVSTFEGWPGLLYVSIDSHDEDEGPIHNFRPIVAIFFIVYIIIIAFFMVNIFVG 493
Query: 1096 VLSGEFSKEREK 1131
+ F E E+
Sbjct: 494 FVIVTFQNEGEQ 505
Score = 92.8 bits (229), Expect = 8e-17
Identities = 85/356 (23%), Positives = 147/356 (40%), Gaps = 31/356 (8%)
Frame = +1
Query: 262 KPFEFLILFMICANCIALAI-YQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMG 438
+PFE+ I +I N I LA+ + P D+ L+ + +F VF +E V K+ A
Sbjct: 549 QPFEYTIFILIMLNTITLAMKFYNQPKYYEDF----LDVLNIIFTAVFAMEFVFKLAAFR 604
Query: 439 FMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--------FDVKALRAFRVLRPL 594
F Y NAWN+ DFIIV+ + I S+++ + R FRV+R +
Sbjct: 605 F----KNYFGNAWNVFDFIIVLGSFIDIIYSEVNTPTRLKPGSGMISINFFRLFRVMRLV 660
Query: 595 RLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQ 774
+L+S ++ +L +++ L ++ALL++ + IYA+IG+++F G+
Sbjct: 661 KLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMF-------------GK 707
Query: 775 LAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLT 954
+A T + NF F A+L
Sbjct: 708 IALDSGTAIHRN------------------------------------NNFQTFPQAVLL 731
Query: 955 VFQCVSLEGWTDVMY--WVNDAV--------------GREWPWIYFVTLVILGSFFVLNL 1086
+F+ + E W D+M D V G + + YF++ +L SF ++NL
Sbjct: 732 LFRSATGEAWQDIMLDGSARDGVRCDSESDEKDKPICGSDMAFPYFISFYVLCSFLIINL 791
Query: 1087 VLGVLSGEF---SKEREKARARGLFQKFREKQQLEEDLKG---YLDWITQAEDIEP 1236
+ V+ F +++ L + R + + D KG +LD +T I P
Sbjct: 792 FVAVIMDNFDYLTRDWSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISP 847
Score = 70.5 bits (171), Expect = 5e-10
Identities = 53/256 (20%), Positives = 102/256 (39%), Gaps = 20/256 (7%)
Frame = +1
Query: 1408 VKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGF 1587
V SQ F + + Y Q ++ + F + N+ F +F+ME + K+ + F
Sbjct: 546 VTSQPFEYTIFILIMLNTITLAMKFYNQPKYYEDFLDVLNIIFTAVFAMEFVFKLAAFRF 605
Query: 1588 TTYTTSQFNRFDCFVVISSILEFVLVYFDLMKP---------LGVSVLRSARLLRIFKVT 1740
Y + +N FD +V+ S ++ ++Y ++ P + ++ R R++R+ K+
Sbjct: 606 KNYFGNAWNVFDFIIVLGSFID--IIYSEVNTPTRLKPGSGMISINFFRLFRVMRLVKLL 663
Query: 1741 KYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFD 1920
GMQ+FG + NF
Sbjct: 664 SRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALDSGTAIHRNNNFQ 723
Query: 1921 TFVQALLTVFQILTGEDWNTVMY-----HGIESFGGVGTLGVIVC------IYYIVLFIC 2067
TF QA+L +F+ TGE W +M G+ +C Y+I ++
Sbjct: 724 TFPQAVLLLFRSATGEAWQDIMLDGSARDGVRCDSESDEKDKPICGSDMAFPYFISFYVL 783
Query: 2068 GNYILLNVFLAIAVDN 2115
+++++N+F+A+ +DN
Sbjct: 784 CSFLIINLFVAVIMDN 799
Score = 52.8 bits (125), Expect = 1e-04
Identities = 52/233 (22%), Positives = 89/233 (37%), Gaps = 38/233 (16%)
Frame = +1
Query: 1525 NLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLG 1692
++FF +F++E+ LKM S GF + S FN D VV S++ + +
Sbjct: 267 DIFFTSVFTIEICLKMISYGFVLHDGAFCRSAFNLLDMLVVFVSLIAMFIRGSAISV--- 323
Query: 1693 VSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGG 1872
+ +LR R+LR + G+Q+F G
Sbjct: 324 IKILRVMRVLRPLRTINRAKGLKHVVQCVIVAVKTIGNIVLVTCLVQFMFAVIGVQLFKG 383
Query: 1873 KF----------------------NFNPQQP--------KPRANFDTFVQALLTVFQILT 1962
KF + + QP + R +FD +A+LT+F + T
Sbjct: 384 KFFRCSDGSKMTEAECHGTYLVFDDGDINQPEVEERRWTRNRFHFDDVAKAMLTLFTVST 443
Query: 1963 GEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
E W ++Y I+S G + IV I++IV I + ++N+F+ +
Sbjct: 444 FEGWPGLLYVSIDSHDEDEGPIHNFRPIVAIFFIVYIIIIAFFMVNIFVGFVI 496
Score = 47.4 bits (111), Expect = 0.004
Identities = 38/133 (28%), Positives = 59/133 (43%), Gaps = 18/133 (13%)
Frame = +1
Query: 919 TNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVG-----REWPWIYFVTLVILGSFFVLN 1083
+NFD+F ++LTVFQ ++ E W VMY A G +YF+ L I G++ +LN
Sbjct: 17 SNFDSFWQSLLTVFQILTGEDWNAVMYVGIQAYGGVSSIGVLACVYFIILFICGNYILLN 76
Query: 1084 LVLGV-------------LSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAE 1224
+ L + + E +E EK + RE+ Q EE G
Sbjct: 77 VFLAIAVDNLADAESLTAIEKEAEEEAEKQQKSHSGSPAREEGQPEEGEGGEEPEKGLVN 136
Query: 1225 DIEPVNEDEQEDE 1263
+ E + ++E E E
Sbjct: 137 ETENLEKEETESE 149
>gi|47550741|ref|NP_999891.1| skeletal muscle L-type calcium channel
alpha1S subunit [Danio rerio]
gi|40647585|gb|AAR88506.1| skeletal muscle L-type calcium channel
alpha1S subunit [Danio rerio]
Length = 1847
Score = 918 bits (2373), Expect = 0.0
Identities = 523/1108 (47%), Positives = 686/1108 (61%), Gaps = 34/1108 (3%)
Frame = +1
Query: 2260 SARPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSA 2439
S RPR M+++ TV P+P+ASS FI N FR C+ ++NH+ FTN +L IL+SS
Sbjct: 775 SPRPRPMADLQLKETVVPMPEASSFFIFGPQNKFRKLCHRIINHTTFTNIILLFILLSSI 834
Query: 2440 MLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDIL 2619
LAAEDP+ +S RN +L Y D FT+VFT+EI LK+ V+G H GSFCRN+FN+LD++
Sbjct: 835 SLAAEDPIDPHSFRNKVLAYADIVFTTVFTIEIVLKMTVYGAFLHPGSFCRNSFNILDLI 894
Query: 2620 VVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLV 2799
VVAVSL S + + +S AINRAKGLKHVVQC+ VA+KTIGNI+LV
Sbjct: 895 VVAVSLLSMGMESSTISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAIKTIGNIVLV 954
Query: 2800 TFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNND 2979
T +L FMF+ IGVQLFKGT F C D + T +C+G ++ + +R W N+D
Sbjct: 955 TMLLDFMFSCIGVQLFKGTLFYCTDPLQKTAEQCQGTFLKHVQNSLHDTEIHQRRWVNSD 1014
Query: 2980 FNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXX 3159
FNFDNV + M++LF +STFEGWP++LY AIDS + D GP++N+R +++
Sbjct: 1015 FNFDNVLNGMLALFTISTFEGWPEILYKAIDSYDVDTGPLYNNRVGISIFFIIYIIIIAF 1074
Query: 3160 XXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWF 3339
GFVIVTFQ +GE+EY+NCELDKNQR+C+++ALKA+P + YIP N QYRVW+
Sbjct: 1075 FMMNIFVGFVIVTFQRQGEQEYKNCELDKNQRQCVQYALKARPLKCYIPENPHQYRVWYL 1134
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
VTS FEY++F +I++NT+SL ++ D N+IFT +F E ++K++A
Sbjct: 1135 VTSCYFEYLMFFLIMLNTLSLGMQYCNQPFYITKLSDNLNVIFTVLFTGEMIVKLIAFKA 1194
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLN-----PGG--------------------TNL 3624
K Y D WNVFD ++V+GS +D+ +++ GG
Sbjct: 1195 KGYFGDPWNVFDFVIVIGSIVDVVLSEVDRTLEASGGLWCLHGCSEVDPMQAIAEAENVK 1254
Query: 3625 ISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF 3804
+SI FFRLFRV+RL+KLL+R EGIR LLWTF+KSFQALP+V LLIV+LFFIYAVIGMQ F
Sbjct: 1255 LSITFFRLFRVLRLIKLLNRSEGIRNLLWTFIKSFQALPHVGLLIVMLFFIYAVIGMQMF 1314
Query: 3805 GKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHK 3984
GK+AL D T I+RNNNF +FP A+L+LFR ATGE W IML + CDP S DY
Sbjct: 1315 GKIALVDGTEINRNNNFQTFPQAVLLLFRVATGEQWPKIML--ASMYGKLCDPKS-DYGP 1371
Query: 3985 GGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVR 4164
G E CG++ A YF+SF+MLC+FLVINLFVA+IMDNFDYLT DWSILGPHHL+EF +
Sbjct: 1372 G--EEYTCGSSIAVCYFLSFYMLCAFLVINLFVAIIMDNFDYLTHDWSILGPHHLDEFKK 1429
Query: 4165 LWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFN 4344
+W EYDP+A GRIKHLDVVTLLR+I PPLGFGK CPH ACKRL+SMNMPLNSDGTV FN
Sbjct: 1430 IWGEYDPEATGRIKHLDVVTLLRRIQPPLGFGKFCPHHAACKRLISMNMPLNSDGTVTFN 1489
Query: 4345 ATLFALVRTNLKIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKF 4524
ATLFALVRT LKI TEGN ++ANE+LR+ IK IWKRT LLD+V+PP G ED+VTVGKF
Sbjct: 1490 ATLFALVRTALKIKTEGNFEQANEELRAIIKSIWKRTSMKLLDQVIPPIG-EDEVTVGKF 1548
Query: 4525 YATFLIQDYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTL-HEIGPELKRAISGNLET 4701
YATFLIQ++FR+F +R+E E G P + A ++AGLR++ E PEL RAISG+L
Sbjct: 1549 YATFLIQEHFRKFMQRQE-ELYGYRPTK-KNADEIKAGLRSIEEEAAPELHRAISGDLIA 1606
Query: 4702 DFNFDEPEPQHRRPHSLFNNLVHRLSGAGSKSPTEHERIEKGSTLLPFQPRSFSPTHSLA 4881
+ DE E R ++R +G G L P S P+
Sbjct: 1607 E---DEME----RAMESGEEGIYRRTG--------------GLFGLNADPFSSEPS---- 1641
Query: 4882 GAEGSPVPSQMHRGAPINQSINLPPVNGSARRLPALPPYANHIHDETDDGPRYRDTGDRA 5061
SP+ +Q+ P+ + N P GS LP + D+ P +T + A
Sbjct: 1642 ----SPLSTQVTSQRPLQFAENRPEDAGSPPDSVFLP----NTEFFPDNMPTTSNTNNNA 1693
Query: 5062 GYDQ----SSRMVVANRNLPVDPDEEEQWMRSGGPSNRSDRRNPHLREPMLVXXXXXXXX 5229
+ + S + A+RN + D + + GG SN +DRR
Sbjct: 1694 NFIEEFTFESESLSASRNYSYE-DIRDSSLYVGGASNVNDRR---------------LSD 1737
Query: 5230 XXMSSEAYEGTYRPVGEGKSVRLPFSSRPVLRPAEDSRPVDRLIGQSL---GLGRYA-DA 5397
+ + + + Y P E S+ AE S D+LI Q+L GL A D
Sbjct: 1738 FNVKTNSTQFPYNPSCE--------ESKNQRSAAEASPATDKLIQQALRDGGLESLAEDP 1789
Query: 5398 RIVGAARREIEEAYSLGEQEIDLAADSL 5481
+ V R+E+ EA ++G Q+I+ A +
Sbjct: 1790 QFVSVTRKELAEAVNIGLQDIESVAQGI 1817
Score = 629 bits (1621), Expect = e-178
Identities = 322/653 (49%), Positives = 431/653 (65%), Gaps = 12/653 (1%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP RK C +IVEWKPFE +IL I ANC+ALA++ P P +D++ N LE++EY+F+V+F
Sbjct: 61 NPFRKACTNIVEWKPFEIIILLTIFANCVALAVFLPMPEEDTNNTNLTLESLEYIFLVIF 120
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGL----VSTILSKMSIQ-----GFD 555
T+EC LKI+A G +FH AYLRN WNILDF+IV +GL V TI + +Q GFD
Sbjct: 121 TLECFLKIIAYGLLFHEGAYLRNCWNILDFVIVFMGLFTLVVDTIDTITGVQKEKGGGFD 180
Query: 556 VKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCG 735
+KALRAFRVLRPLRLVSGVPSLQVV++++L++M+PL HI LLV F++ IYAI+GLELF
Sbjct: 181 MKALRAFRVLRPLRLVSGVPSLQVVMSSVLKSMLPLFHILLLVFFMVTIYAIMGLELFKC 240
Query: 736 KLHSTCIDPATGQLAQKD---PTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGP 906
K+H TC T +A ++ P+PC G+ +C + + EC WPGP
Sbjct: 241 KMHKTCYYQGTNIIALRENEKPSPCAQ--AGNGRRCTINGT--------ECRDG--WPGP 288
Query: 907 NNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNL 1086
N GIT+FDNFG AMLTVFQC++ E WTDV+YW+NDA+G +WPWIYF++L++LGSFF+LNL
Sbjct: 289 NFGITHFDNFGFAMLTVFQCITTESWTDVLYWINDAMGNDWPWIYFLSLIMLGSFFILNL 348
Query: 1087 VLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEP 1266
VLGVLSGEF+KEREK+R+RG +Q RE+QQ++EDLKGY++WIT AE ++ ++
Sbjct: 349 VLGVLSGEFTKEREKSRSRGEWQVLRERQQMDEDLKGYMEWITHAEVMDGDSD------- 401
Query: 1267 VAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXX 1446
A +K + + N VKS++F W
Sbjct: 402 -AMLLLRKDTGSETDSLYKMEGINKVVYFYRLARRWNIVIRRKCHGWVKSKSFNWWVLIV 460
Query: 1447 XXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDC 1626
+EH+ Q+E L +FQ AN+ + F++EM++KMY+ G +Y S FNRFDC
Sbjct: 461 VLLNTLVIATEHHNQTEGLTNFQDTANVILLACFTIEMIMKMYAFGPRSYFMSIFNRFDC 520
Query: 1627 FVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXX 1806
FVV ILE +LV +M PLG+SV+R RLLR+FK+TKYWT
Sbjct: 521 FVVTIGILEIILVGSGIMTPLGISVMRCIRLLRLFKLTKYWTSLNNLVVSLLNSVKSIAS 580
Query: 1807 XXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVM 1986
GMQVFGGKFNF P +P R+NFD F QAL++VFQ+LTGE+W+T+M
Sbjct: 581 LLLLLFLFIVIFALLGMQVFGGKFNF-PDRPIQRSNFDNFPQALISVFQVLTGEEWDTIM 639
Query: 1987 YHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNA 2145
Y+GI + GG + G++V IY+I+L++CGN++LLNVFLAIAVDNLA+A+SL A
Sbjct: 640 YNGIMAHGGPKSPGILVSIYFIILYVCGNFVLLNVFLAIAVDNLAEAESLAAA 692
Score = 134 bits (337), Expect = 3e-29
Identities = 102/344 (29%), Positives = 163/344 (46%), Gaps = 12/344 (3%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++T V N RKLC I+ F +IL I + I+L
Sbjct: 777 RPRPMADLQLKETVVPMPEASSFFIFGPQNKFRKLCHRIINHTTFTNIILLFILLSSISL 836
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P ++N +L + VF VFTIE VLK+ G HP ++ RN++NILD I
Sbjct: 837 AAEDPIDPHS--FRNKVLAYADIVFTTVFTIEIVLKMTVYGAFLHPGSFCRNSFNILDLI 894
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S + +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 895 VVAVSLLSMGMESSTIS--VVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAIKTIGNIV 952
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLT 855
L+ + + +++ IG++LF G L C DP QK C +G+ K +SL
Sbjct: 953 LVTMLLDFMFSCIGVQLFKGTLF-YCTDP-----LQKTAEQC----QGTFLK-HVQNSLH 1001
Query: 856 NMGV---RWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAV--- 1017
+ + RW N NFDN ML +F + EGW +++Y D+
Sbjct: 1002 DTEIHQRRWV-----------NSDFNFDNVLNGMLALFTISTFEGWPEILYKAIDSYDVD 1050
Query: 1018 ------GREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
R I+F+ +I+ +FF++N+ +G + F ++ E+
Sbjct: 1051 TGPLYNNRVGISIFFIIYIIIIAFFMMNIFVGFVIVTFQRQGEQ 1094
Score = 114 bits (285), Expect = 3e-23
Identities = 69/255 (27%), Positives = 129/255 (50%)
Frame = +1
Query: 3337 FVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALN 3516
+V S++F + + +++++NT+ +A +H+ + G +F D N+I F E ++K+ A
Sbjct: 447 WVKSKSFNWWVLIVVLLNTLVIATEHHNQTEGLTNFQDTANVILLACFTIEMIMKMYAFG 506
Query: 3517 PKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGI 3696
P++Y +N FD VV ++I + G + I+ R R++RL KL +
Sbjct: 507 PRSYFMSIFNRFDCFVVTIGILEIIL--VGSGIMTPLGISVMRCIRLLRLFKLTKYWTSL 564
Query: 3697 RTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + + S +++ + LL+ L I+A++GMQ FG I R +NF +FP A+
Sbjct: 565 NNLVVSLLNSVKSIASLLLLLFLFIVIFALLGMQVFGGKFNFPDRPIQR-SNFDNFPQAL 623
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLC 4056
+ +F+ TGE W IM + H G + YFI ++
Sbjct: 624 ISVFQVLTGEEWDTIMYN------------GIMAHGG----PKSPGILVSIYFIILYVCG 667
Query: 4057 SFLVINLFVAVIMDN 4101
+F+++N+F+A+ +DN
Sbjct: 668 NFVLLNVFLAIAVDN 682
Score = 92.4 bits (228), Expect = 1e-16
Identities = 70/276 (25%), Positives = 125/276 (44%), Gaps = 23/276 (8%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRN--MILNYF 2502
+LF N FR C +V F +L I + LA P+ T N + L
Sbjct: 53 TLFFFKLRNPFRKACTNIVEWKPFEIIILLTIFANCVALAVFLPMPEEDTNNTNLTLESL 112
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRT-DAMSXXX 2679
+Y F +FT+E LK+I +GL+FH+G++ RN +N+LD ++V + L + V+ T D ++
Sbjct: 113 EYIFLVIFTLECFLKIIAYGLLFHEGAYLRNCWNILDFVIVFMGLFTLVVDTIDTITGVQ 172
Query: 2680 XXXXXXXXXXXXA----------INRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAI 2829
++ L+ V+ V+ ++ + +I+L+ F + ++AI
Sbjct: 173 KEKGGGFDMKALRAFRVLRPLRLVSGVPSLQVVMSSVLKSMLPLFHILLLVFFMVTIYAI 232
Query: 2830 IGVQLFK-----GTFFLCNDLSKMTEAECRGEYIHYEDGD--PTKPVSKKRVWSNNDF-- 2982
+G++LFK ++ ++ + E E +G + W +F
Sbjct: 233 MGLELFKCKMHKTCYYQGTNIIALRENEKPSPCAQAGNGRRCTINGTECRDGWPGPNFGI 292
Query: 2983 -NFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEED 3087
+FDN G AM+++F T E W +LY D+ D
Sbjct: 293 THFDNFGFAMLTVFQCITTESWTDVLYWINDAMGND 328
Score = 85.1 bits (209), Expect = 2e-14
Identities = 86/400 (21%), Positives = 153/400 (37%), Gaps = 5/400 (1%)
Frame = +1
Query: 1912 NFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNV 2091
+FD F A+LTVFQ +T E W V+Y ++ G IY++ L + G++ +LN+
Sbjct: 294 HFDNFGFAMLTVFQCITTESWTDVLYWINDAMGNDWPW-----IYFLSLIMLGSFFILNL 348
Query: 2092 FLAIAVDNLADADSLTNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSARP 2271
L + + + M R
Sbjct: 349 VLGVLSGEFTKEREKSRSRGEWQVLRERQQMDEDLKGYMEWITHAEVMDGDSDAMLLLRK 408
Query: 2272 RRMSEVPAASTVKPIPKASSLFILSHTNSF--RVFCNMVVNHSYFTNAVLFCILVSSAML 2445
SE + ++ I K + L+ + R C+ V F VL +L+++ ++
Sbjct: 409 DTGSETDSLYKMEGINKVVYFYRLARRWNIVIRRKCHGWVKSKSFNWWVLIVVLLNTLVI 468
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
A E Q N + + + FT+E+ +K+ FG S+ + FN D VV
Sbjct: 469 ATEHHNQTEGLTNF-QDTANVILLACFTIEMIMKMYAFG----PRSYFMSIFNRFDCFVV 523
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQCVIVAVKTIGNIML 2796
+ + +L + K L ++V ++ +VK+I +++L
Sbjct: 524 TIGILEIILVGSGIMTPLGISVMRCIRLLRLFKLTKYWTSLNNLVVSLLNSVKSIASLLL 583
Query: 2797 VTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNN 2976
+ F+ +FA++G+Q+F G F P +P+ +
Sbjct: 584 LLFLFIVIFALLGMQVFGGKF-----------------------NFPDRPIQRS------ 614
Query: 2977 DFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGP 3096
NFDN A+IS+F V T E W ++Y I ++ K P
Sbjct: 615 --NFDNFPQALISVFQVLTGEEWDTIMYNGIMAHGGPKSP 652
Score = 79.7 bits (195), Expect = 7e-13
Identities = 80/342 (23%), Positives = 139/342 (40%), Gaps = 18/342 (5%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
N IR+ C V+ K F + +L ++ N + +A ++ +T + +
Sbjct: 437 NIVIRRKCHGWVKSKSFNWWVLIVVLLNTLVIATEHH---NQTEGLTNFQDTANVILLAC 493
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG-FDVKALRAF 576
FTIE ++K+ A G P +Y + +N D +V IG++ IL I + +R
Sbjct: 494 FTIEMIMKMYAFG----PRSYFMSIFNRFDCFVVTIGILEIILVGSGIMTPLGISVMRCI 549
Query: 577 RVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI 756
R+LR +L SL ++ ++L ++ + + LL+ I+I+A++
Sbjct: 550 RLLRLFKLTKYWTSLNNLVVSLLNSVKSIASLLLLLFLFIVIFALL-------------- 595
Query: 757 DPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNF 936
G G F +P +NFDNF
Sbjct: 596 ---------------GMQVFGGKFN---------------------FPDRPIQRSNFDNF 619
Query: 937 GLAMLTVFQCVSLEGWTDVMYWVNDAVGREWP-------WIYFVTLVILGSFFVLNLVLG 1095
A+++VFQ ++ E W +MY N + P IYF+ L + G+F +LN+ L
Sbjct: 620 PQALISVFQVLTGEEWDTIMY--NGIMAHGGPKSPGILVSIYFIILYVCGNFVLLNVFLA 677
Query: 1096 VLSGEFS---------KEREKARAR-GLFQKFREKQQLEEDL 1191
+ + KER + RAR L + EK + E+ L
Sbjct: 678 IAVDNLAEAESLAAAQKERAEERARKKLMKPLPEKTEEEKAL 719
Score = 77.0 bits (188), Expect = 5e-12
Identities = 72/329 (21%), Positives = 131/329 (38%), Gaps = 47/329 (14%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIY---QPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMG 438
FE+L+ F+I N ++L + QP+ Y L + + +F V+FT E ++K++A
Sbjct: 1140 FEYLMFFLIMLNTLSLGMQYCNQPF------YITKLSDNLNVIFTVLFTGEMIVKLIA-- 1191
Query: 439 FMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMS-----------IQG------------ 549
F Y + WN+ DF+IV+ +V +LS++ + G
Sbjct: 1192 --FKAKGYFGDPWNVFDFVIVIGSIVDVVLSEVDRTLEASGGLWCLHGCSEVDPMQAIAE 1249
Query: 550 -----FDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAII 714
+ R FRVLR ++L++ ++ +L +++ L H+ LL++ + IYA+I
Sbjct: 1250 AENVKLSITFFRLFRVLRLIKLLNRSEGIRNLLWTFIKSFQALPHVGLLIVMLFFIYAVI 1309
Query: 715 GLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTT 894
G+++F G++A D T
Sbjct: 1310 GMQMF-------------GKIALVDGTEI------------------------------- 1325
Query: 895 WPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVM--------------YWVND--AVGRE 1026
N NF F A+L +F+ + E W +M Y + G
Sbjct: 1326 -----NRNNNFQTFPQAVLLLFRVATGEQWPKIMLASMYGKLCDPKSDYGPGEEYTCGSS 1380
Query: 1027 WPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
YF++ +L +F V+NL + ++ F
Sbjct: 1381 IAVCYFLSFYMLCAFLVINLFVAIIMDNF 1409
Score = 75.9 bits (185), Expect = 1e-11
Identities = 86/359 (23%), Positives = 148/359 (40%), Gaps = 63/359 (17%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLAC---KHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE +I L I N V+LA + L+ IF +F E LKI+A
Sbjct: 74 KPFEIIILLTIFANCVALAVFLPMPEEDTNNTNLTLESLEYIFLVIFTLECFLKIIAYGL 133
Query: 3511 -LNPKNYISDRWNVFDLLVV-VGSF------IDITYG--KLNPGGTNLISINFFRLFRVM 3660
+ Y+ + WN+ D ++V +G F ID G K GG ++ ++ FR+ R +
Sbjct: 134 LFHEGAYLRNCWNILDFVIVFMGLFTLVVDTIDTITGVQKEKGGGFDMKALRAFRVLRPL 193
Query: 3661 RLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF----GKVALDDS 3828
RLV S ++ ++ + +KS L ++ LL+ + IYA++G++ F K
Sbjct: 194 RLV---SGVPSLQVVMSSVLKSMLPLFHILLLVFFMVTIYAIMGLELFKCKMHKTCYYQG 250
Query: 3829 TSI--HRNN----------------------------------NFHSFPAAILVLFRSAT 3900
T+I R N +F +F A+L +F+ T
Sbjct: 251 TNIIALRENEKPSPCAQAGNGRRCTINGTECRDGWPGPNFGITHFDNFGFAMLTVFQCIT 310
Query: 3901 GEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLF 4080
E+W D++ +D GN++ + YF+S ML SF ++NL
Sbjct: 311 TESWTDVLYWIND---------------------AMGNDWPWIYFLSLIMLGSFFILNLV 349
Query: 4081 VAVIMDNF------DYLTRDWSILGP-HHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRK 4236
+ V+ F +W +L ++E ++ + E+ A+ D + LLRK
Sbjct: 350 LGVLSGEFTKEREKSRSRGEWQVLRERQQMDEDLKGYMEWITHAEVMDGDSDAMLLLRK 408
Score = 60.1 bits (144), Expect = 6e-07
Identities = 57/252 (22%), Positives = 99/252 (38%), Gaps = 39/252 (15%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
++ Q ++ N+ F +LF+ EM++K+ + Y +N FD +VI SI++
Sbjct: 1158 QYCNQPFYITKLSDNLNVIFTVLFTGEMIVKLIAFKAKGYFGDPWNVFDFVIVIGSIVDV 1217
Query: 1657 VLVYFDLMKP---------------------------LGVSVLRSARLLRIFKVTKYWTX 1755
VL D L ++ R R+LR+ K+
Sbjct: 1218 VLSEVDRTLEASGGLWCLHGCSEVDPMQAIAEAENVKLSITFFRLFRVLRLIKLLNRSEG 1277
Query: 1756 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQA 1935
GMQ+FG + + NF TF QA
Sbjct: 1278 IRNLLWTFIKSFQALPHVGLLIVMLFFIYAVIGMQMFGKIALVDGTEINRNNNFQTFPQA 1337
Query: 1936 LLTVFQILTGEDWNTVMYHGI-------ESFGGVG---TLG--VIVCIYYIVLFICGNYI 2079
+L +F++ TGE W +M + +S G G T G + VC Y++ ++ ++
Sbjct: 1338 VLLLFRVATGEQWPKIMLASMYGKLCDPKSDYGPGEEYTCGSSIAVC-YFLSFYMLCAFL 1396
Query: 2080 LLNVFLAIAVDN 2115
++N+F+AI +DN
Sbjct: 1397 VINLFVAIIMDN 1408
Score = 40.4 bits (93), Expect = 0.50
Identities = 19/70 (27%), Positives = 37/70 (52%), Gaps = 4/70 (5%)
Frame = +1
Query: 1912 NFDTFVQALLTVFQILTGEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYI 2079
NFD + +L +F I T E W ++Y I+S+ G + V + I++I+ I +
Sbjct: 1016 NFDNVLNGMLALFTISTFEGWPEILYKAIDSYDVDTGPLYNNRVGISIFFIIYIIIIAFF 1075
Query: 2080 LLNVFLAIAV 2109
++N+F+ +
Sbjct: 1076 MMNIFVGFVI 1085
>gi|7521913|pir||T30535 calcium channel alpha-1 chain homolog - Fugu
rubripes (fragment)
gi|3098267|gb|AAC15583.1| calcium channel alpha-1 subunit homolog
[Takifugu rubripes]
Length = 1559
Score = 910 bits (2352), Expect = 0.0
Identities = 458/789 (58%), Positives = 573/789 (72%), Gaps = 16/789 (2%)
Frame = +1
Query: 2260 SARPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSA 2439
S RPR M+++ P+P+ASS FI N FR C ++N S FTN +L IL+SS
Sbjct: 765 SPRPRPMADLQLKEEAVPLPEASSFFIFGPQNKFRKLCYKIINASSFTNLILLFILLSSI 824
Query: 2440 MLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDIL 2619
LAAEDP+ S RN IL Y D FT+VFT+EI LK+ V+G HKGSFCRN+FN+LD++
Sbjct: 825 SLAAEDPIDPKSYRNQILAYADIVFTTVFTIEIVLKMTVYGAFMHKGSFCRNSFNILDLI 884
Query: 2620 VVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLV 2799
VV VSL S + + A+S AINRAKGLKHVVQCV VA+KTIGNI+LV
Sbjct: 885 VVGVSLLSMGMESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIKTIGNIVLV 944
Query: 2800 TFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNND 2979
T +L FMFA IGVQLFKG F+ C DLSK+T EC+G ++ + + V +R+W N+D
Sbjct: 945 TMLLNFMFACIGVQLFKGKFYSCTDLSKVTHEECQGFFLKHMENSLQDTVLAERMWLNSD 1004
Query: 2980 FNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXX 3159
FNFDNV M++LF VST EGWP+LLY AIDS++ED GP+ N+R V++
Sbjct: 1005 FNFDNVLYGMLALFTVSTIEGWPELLYRAIDSDKEDMGPVFNNRVDVSIFFIVYIILIAF 1064
Query: 3160 XXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWF 3339
GFVIVTFQ +GE+EY++CELDKNQR+C+++ALKA+P R YIP+N QYRVW+
Sbjct: 1065 FMMNIFVGFVIVTFQEQGEQEYKDCELDKNQRQCVQYALKARPLRCYIPKNPYQYRVWYI 1124
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
VTS FEY++F +I++NT+ L +H S D+ NLIFT +F E +LK++A
Sbjct: 1125 VTSCYFEYLMFFLIMLNTLCLGMQHCNQSDHVTKLSDMLNLIFTVLFTVEMILKLMAFKI 1184
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNP-----GGTNL-----------ISINFFRLF 3651
K Y D WNVFD ++V+GS +D+ +++ GG +SI FFRLF
Sbjct: 1185 KGYFGDPWNVFDFIIVIGSVVDVILSEVDTALASSGGLYCLHGCADSENASVSITFFRLF 1244
Query: 3652 RVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDST 3831
RVMRLVKLL+R EGIR LLWTF+KSFQALP+VALLIV+LFFIYAVIGMQ FGKVAL D T
Sbjct: 1245 RVMRLVKLLNRSEGIRNLLWTFIKSFQALPHVALLIVMLFFIYAVIGMQIFGKVALLDGT 1304
Query: 3832 SIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCG 4011
IHRNNNF +FP A+L+LFR ATGE WQ++M++ + +CDP SD + G E CG
Sbjct: 1305 QIHRNNNFQTFPQAVLMLFRCATGEDWQEVMMASMYGK--KCDPKSD-FLPG--EEYTCG 1359
Query: 4012 NNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDA 4191
+NFA YF+SF+ LC+FL++NLFVAVIMDNFDYLTRDWS+LGPHHL+EF ++W+EYDP+A
Sbjct: 1360 SNFAVIYFLSFYCLCAFLILNLFVAVIMDNFDYLTRDWSLLGPHHLDEFKKIWAEYDPEA 1419
Query: 4192 KGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRT 4371
GRIKHLDVVTLLR+I PPLGFGK CPHR ACKRLV MNMPLNSDGTV FNATLFALVRT
Sbjct: 1420 TGRIKHLDVVTLLRRIQPPLGFGKFCPHRAACKRLVGMNMPLNSDGTVTFNATLFALVRT 1479
Query: 4372 NLKIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDY 4551
LKI TEGN ++ANE+LR+ IK+IWKRT LLD+V+PP G +D+VTVGKFYATFL+QD+
Sbjct: 1480 ALKIKTEGNFEKANEELRAIIKQIWKRTSMKLLDQVIPPIG-DDEVTVGKFYATFLLQDH 1538
Query: 4552 FRRFKKRKE 4578
FR+F K +E
Sbjct: 1539 FRKFLKCQE 1547
Score = 639 bits (1649), Expect = 0.0
Identities = 338/682 (49%), Positives = 434/682 (63%), Gaps = 12/682 (1%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+K+ + K L+ T NP RK CI+IVEWK FE +IL I ANC+AL
Sbjct: 20 RKQKEKLKKLQATGGNPRPTRSLFFFTLKNPFRKACINIVEWKAFEIIILLTIFANCVAL 79
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A++ P P +DS+ N LE++EY+F+V+FT+EC LKIVA GF+FH AYLRN WNILDF+
Sbjct: 80 AVFLPMPEEDSNNTNASLESLEYIFLVIFTLECFLKIVAYGFVFHEGAYLRNCWNILDFV 139
Query: 496 IVVIGLVSTILSKMSI---------QGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILR 648
IV +GL + L ++ GFD+KALRAFRVLRPLRLVSGVPSLQVV+N+IL+
Sbjct: 140 IVFMGLFTFALDTINKIAGVPLEKGGGFDMKALRAFRVLRPLRLVSGVPSLQVVMNSILK 199
Query: 649 AMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKD---PTPCGTDTEG 819
AM+PLLHIALLV ++ IYAI+GLELF K+H TC T + + P PC G
Sbjct: 200 AMLPLLHIALLVFLLVTIYAIMGLELFKCKMHKTCYYTGTNIYSTAEGELPAPCAQ--AG 257
Query: 820 SAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMY 999
+ +C + S EC W GPNNGIT+FDN G AMLTV+QC+++EGWT V+Y
Sbjct: 258 NGRRCTINGS--------ECRPG--WEGPNNGITHFDNIGFAMLTVYQCITMEGWTKVLY 307
Query: 1000 WVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQQL 1179
WVNDA+G EWPW+YFV L++LGSFFVLNLVLGVLSGEF+KEREKAR+RG FQK RE+QQL
Sbjct: 308 WVNDAIGNEWPWLYFVPLILLGSFFVLNLVLGVLSGEFTKEREKARSRGEFQKLRERQQL 367
Query: 1180 EEDLKGYLDWITQAEDIEPVNEDEQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMK 1359
+EDL GY++WIT AE ++ + + + P+ + A R
Sbjct: 368 DEDLHGYMEWITHAEVLD-ADREGKGLLPLTSGDSDTDSLYGLEGKSRIIYYYRLARRWN 426
Query: 1360 RLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFV 1539
R ++ VK+++FYW +EH+ Q EWL Q +A+ +
Sbjct: 427 RFFRMK------CLVYVKTKSFYWLVMFLVFLNTLTIATEHHHQPEWLTSLQDVASRVLL 480
Query: 1540 ILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARL 1719
+LF +EM +KMY+LG Y S FNRFD FVV+ ILE ++ + PLG SVLR RL
Sbjct: 481 VLFIVEMFIKMYALGLRAYFMSLFNRFDFFVVLCGILEMIMFSAGAVTPLGFSVLRCIRL 540
Query: 1720 LRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQP 1899
LRI KVTKYWT GMQVFGGKFNF+ +P
Sbjct: 541 LRILKVTKYWTSLSNLVASLLNSVRSIASLLLLLFLFIVIFSLLGMQVFGGKFNFSDHRP 600
Query: 1900 KPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYI 2079
+ R+NFD F QAL++VFQILTGE+W +MY+GI ++GG G++V IY+IVLF+CGNYI
Sbjct: 601 R-RSNFDNFPQALISVFQILTGEEWTNIMYNGIMAYGGPVIPGILVSIYFIVLFVCGNYI 659
Query: 2080 LLNVFLAIAVDNLADADSLTNA 2145
LLNVFLAIAVDNLA+A+SLT+A
Sbjct: 660 LLNVFLAIAVDNLAEAESLTSA 681
Score = 131 bits (330), Expect = 2e-28
Identities = 102/341 (29%), Positives = 164/341 (47%), Gaps = 9/341 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V N RKLC I+ F LIL I + I+L
Sbjct: 767 RPRPMADLQLKEEAVPLPEASSFFIFGPQNKFRKLCYKIINASSFTNLILLFILLSSISL 826
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P + Y+N +L + VF VFTIE VLK+ G H ++ RN++NILD I
Sbjct: 827 AAEDPIDPKS--YRNQILAYADIVFTTVFTIEIVLKMTVYGAFMHKGSFCRNSFNILDLI 884
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S + +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 885 VVGVSLLSMGMESSAIS--VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIKTIGNIV 942
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLT 855
L+ + + ++A IG++LF GK +S C D L++ C +G K +SL
Sbjct: 943 LVTMLLNFMFACIGVQLFKGKFYS-CTD-----LSKVTHEEC----QGFFLK-HMENSLQ 991
Query: 856 NMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDA------- 1014
+ + + W N NFDN ML +F ++EGW +++Y D+
Sbjct: 992 DTVL-----AERMW---LNSDFNFDNVLYGMLALFTVSTIEGWPELLYRAIDSDKEDMGP 1043
Query: 1015 --VGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
R I+F+ +IL +FF++N+ +G + F ++ E+
Sbjct: 1044 VFNNRVDVSIFFIVYIILIAFFMMNIFVGFVIVTFQEQGEQ 1084
Score = 97.8 bits (242), Expect = 3e-18
Identities = 61/255 (23%), Positives = 128/255 (49%)
Frame = +1
Query: 3337 FVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALN 3516
+V +++F +++ ++ +NT+++A +H+ DV + + +F E +K+ AL
Sbjct: 436 YVKTKSFYWLVMFLVFLNTLTIATEHHHQPEWLTSLQDVASRVLLVLFIVEMFIKMYALG 495
Query: 3517 PKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGI 3696
+ Y +N FD VV+ +++ + G + + R R++R++K+ +
Sbjct: 496 LRAYFMSLFNRFDFFVVLCGILEMIM--FSAGAVTPLGFSVLRCIRLLRILKVTKYWTSL 553
Query: 3697 RTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + + S +++ + LL+ L I++++GMQ FG + S R +NF +FP A+
Sbjct: 554 SNLVASLLNSVRSIASLLLLLFLFIVIFSLLGMQVFGG-KFNFSDHRPRRSNFDNFPQAL 612
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLC 4056
+ +F+ TGE W +IM + P G+ S YFI F+
Sbjct: 613 ISVFQILTGEEWTNIMYNGIMAYGGPVIP--------GILVS--------IYFIVLFVCG 656
Query: 4057 SFLVINLFVAVIMDN 4101
+++++N+F+A+ +DN
Sbjct: 657 NYILLNVFLAIAVDN 671
Score = 95.5 bits (236), Expect = 1e-17
Identities = 72/272 (26%), Positives = 127/272 (46%), Gaps = 23/272 (8%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPL--QANSTRNMILNYF 2502
SLF + N FR C +V F +L I + LA P+ + ++ N L
Sbjct: 41 SLFFFTLKNPFRKACINIVEWKAFEIIILLTIFANCVALAVFLPMPEEDSNNTNASLESL 100
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRT-------- 2658
+Y F +FT+E LK++ +G VFH+G++ RN +N+LD ++V + L +F L T
Sbjct: 101 EYIFLVIFTLECFLKIVAYGFVFHEGAYLRNCWNILDFVIVFMGLFTFALDTINKIAGVP 160
Query: 2659 ---DAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAI 2829
++ L+ V+ ++ A+ + +I L+ F+L ++AI
Sbjct: 161 LEKGGGFDMKALRAFRVLRPLRLVSGVPSLQVVMNSILKAMLPLLHIALLVFLLVTIYAI 220
Query: 2830 IGVQLFK-----GTFFLCNDLSKMTEAECRGEYIHYEDGDP-TKPVSKKRV-W---SNND 2979
+G++LFK ++ ++ E E +G T S+ R W +N
Sbjct: 221 MGLELFKCKMHKTCYYTGTNIYSTAEGELPAPCAQAGNGRRCTINGSECRPGWEGPNNGI 280
Query: 2980 FNFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
+FDN+G AM++++ T EGW ++LY D+
Sbjct: 281 THFDNIGFAMLTVYQCITMEGWTKVLYWVNDA 312
Score = 93.2 bits (230), Expect = 6e-17
Identities = 79/332 (23%), Positives = 135/332 (39%), Gaps = 35/332 (10%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP + IV FE+L+ F+I N + L + SD+ L + + +F V+F
Sbjct: 1115 NPYQYRVWYIVTSCYFEYLMFFLIMLNTLCLGMQH---CNQSDHVTKLSDMLNLIFTVLF 1171
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQ------------ 546
T+E +LK++A F Y + WN+ DFIIV+ +V ILS++
Sbjct: 1172 TVEMILKLMA----FKIKGYFGDPWNVFDFIIVIGSVVDVILSEVDTALASSGGLYCLHG 1227
Query: 547 -------GFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIY 705
+ R FRV+R ++L++ ++ +L +++ L H+ALL++ + IY
Sbjct: 1228 CADSENASVSITFFRLFRVMRLVKLLNRSEGIRNLLWTFIKSFQALPHVALLIVMLFFIY 1287
Query: 706 AIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSS 885
A+IG+++F G++A D T +
Sbjct: 1288 AVIGMQIF-------------GKVALLDGTQIHRN------------------------- 1309
Query: 886 NTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMY----------------WVNDAV 1017
NF F A+L +F+C + E W +VM
Sbjct: 1310 -----------NNFQTFPQAVLMLFRCATGEDWQEVMMASMYGKKCDPKSDFLPGEEYTC 1358
Query: 1018 GREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
G + IYF++ L +F +LNL + V+ F
Sbjct: 1359 GSNFAVIYFLSFYCLCAFLILNLFVAVIMDNF 1390
Score = 81.6 bits (200), Expect = 2e-13
Identities = 82/342 (23%), Positives = 142/342 (40%), Gaps = 19/342 (5%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
N R C+ V+ K F +L++F++ N + +A + ++ +L + V +V+
Sbjct: 426 NRFFRMKCLVYVKTKSFYWLVMFLVFLNTLTIATEHHH---QPEWLTSLQDVASRVLLVL 482
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTIL-SKMSIQGFDVKALRAF 576
F +E +K+ A+G AY + +N DF +V+ G++ I+ S ++ LR
Sbjct: 483 FIVEMFIKMYALGLR----AYFMSLFNRFDFFVVLCGILEMIMFSAGAVTPLGFSVLRCI 538
Query: 577 RVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI 756
R+LR L++ SL ++ ++L ++ IA L+L + L I L
Sbjct: 539 RLLRILKVTKYWTSLSNLVASLLNSV---RSIASLLLLLFLFIVIFSL------------ 583
Query: 757 DPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNF 936
G G F N + P +NFDNF
Sbjct: 584 --------------LGMQVFGGKF-------------------NFSDHRPRR--SNFDNF 608
Query: 937 GLAMLTVFQCVSLEGWTDVMYWVNDAVGREWP-------WIYFVTLVILGSFFVLNLVLG 1095
A+++VFQ ++ E WT++MY N + P IYF+ L + G++ +LN+ L
Sbjct: 609 PQALISVFQILTGEEWTNIMY--NGIMAYGGPVIPGILVSIYFIVLFVCGNYILLNVFLA 666
Query: 1096 V-----------LSGEFSKEREKARARGLFQKFREKQQLEED 1188
+ S + K EK R + L K EK E +
Sbjct: 667 IAVDNLAEAESLTSAQKEKAEEKMRRKLLRSKMPEKTDEERE 708
Score = 77.4 bits (189), Expect = 4e-12
Identities = 59/242 (24%), Positives = 96/242 (39%), Gaps = 29/242 (11%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+H QS+ + M NL F +LF++EM+LK+ + Y +N FD +VI S+++
Sbjct: 1148 QHCNQSDHVTKLSDMLNLIFTVLFTVEMILKLMAFKIKGYFGDPWNVFDFIIVIGSVVDV 1207
Query: 1657 VLVYFDLM------------------KPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXX 1782
+L D + ++ R R++R+ K+
Sbjct: 1208 ILSEVDTALASSGGLYCLHGCADSENASVSITFFRLFRVMRLVKLLNRSEGIRNLLWTFI 1267
Query: 1783 XXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILT 1962
GMQ+FG + Q NF TF QA+L +F+ T
Sbjct: 1268 KSFQALPHVALLIVMLFFIYAVIGMQIFGKVALLDGTQIHRNNNFQTFPQAVLMLFRCAT 1327
Query: 1963 GEDWNTVMYHGIESF----------GGVGTLGVIVCIYYIVLFIC-GNYILLNVFLAIAV 2109
GEDW VM + G T G + Y + F C +++LN+F+A+ +
Sbjct: 1328 GEDWQEVMMASMYGKKCDPKSDFLPGEEYTCGSNFAVIYFLSFYCLCAFLILNLFVAVIM 1387
Query: 2110 DN 2115
DN
Sbjct: 1388 DN 1389
Score = 73.6 bits (179), Expect = 5e-11
Identities = 72/308 (23%), Positives = 124/308 (39%), Gaps = 56/308 (18%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLAC---KHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+AFE +I L I N V+LA S L+ IF +F E LKIVA
Sbjct: 62 KAFEIIILLTIFANCVALAVFLPMPEEDSNNTNASLESLEYIFLVIFTLECFLKIVAYGF 121
Query: 3511 -LNPKNYISDRWNVFDLLVVVGSFIDITYGKLNP---------GGTNLISINFFRLFRVM 3660
+ Y+ + WN+ D ++V +N GG ++ ++ R FRV+
Sbjct: 122 VFHEGAYLRNCWNILDFVIVFMGLFTFALDTINKIAGVPLEKGGGFDMKAL---RAFRVL 178
Query: 3661 RLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF----GKVALDDS 3828
R ++L+S ++ ++ + +K+ L ++ALL+ LL IYA++G++ F K
Sbjct: 179 RPLRLVSGVPSLQVVMNSILKAMLPLLHIALLVFLLVTIYAIMGLELFKCKMHKTCYYTG 238
Query: 3829 TSIHR---------------------------------NN---NFHSFPAAILVLFRSAT 3900
T+I+ NN +F + A+L +++ T
Sbjct: 239 TNIYSTAEGELPAPCAQAGNGRRCTINGSECRPGWEGPNNGITHFDNIGFAMLTVYQCIT 298
Query: 3901 GEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLF 4080
E W ++ +D GN + + YF+ +L SF V+NL
Sbjct: 299 MEGWTKVLYWVND---------------------AIGNEWPWLYFVPLILLGSFFVLNLV 337
Query: 4081 VAVIMDNF 4104
+ V+ F
Sbjct: 338 LGVLSGEF 345
Score = 52.8 bits (125), Expect = 1e-04
Identities = 49/240 (20%), Positives = 98/240 (40%), Gaps = 3/240 (1%)
Frame = +1
Query: 2359 FRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEI 2538
FR+ C + V F V+F + +++ +A E Q ++ + +F VE+
Sbjct: 429 FRMKCLVYVKTKSFYWLVMFLVFLNTLTIATEHHHQPEWLTSL-QDVASRVLLVLFIVEM 487
Query: 2539 TLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXA 2718
+K+ GL ++ + FN D VV + ++ +
Sbjct: 488 FIKMYALGL----RAYFMSLFNRFDFFVVLCGILEMIMFSAGAVTPLGFSVLRCIRLLRI 543
Query: 2719 INRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMT 2889
+ K L ++V ++ +V++I +++L+ F+ +F+++G+Q+F G F
Sbjct: 544 LKVTKYWTSLSNLVASLLNSVRSIASLLLLLFLFIVIFSLLGMQVFGGKF---------- 593
Query: 2890 EAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAI 3069
++ D P + NFDN A+IS+F + T E W ++Y I
Sbjct: 594 ---------NFSDHRPRRS------------NFDNFPQALISVFQILTGEEWTNIMYNGI 632
Score = 40.4 bits (93), Expect = 0.50
Identities = 51/234 (21%), Positives = 84/234 (35%), Gaps = 38/234 (16%)
Frame = +1
Query: 1522 ANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPL 1689
A++ F +F++E++LKM G ++ + FN D VV S+L + +
Sbjct: 845 ADIVFTTVFTIEIVLKMTVYGAFMHKGSFCRNSFNILDLIVVGVSLLSMGMESSAISV-- 902
Query: 1690 GVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFG 1869
V +LR R+LR + G+Q+F
Sbjct: 903 -VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIKTIGNIVLVTMLLNFMFACIGVQLFK 961
Query: 1870 GKFNF---------------------NPQQPKPRA---------NFDTFVQALLTVFQIL 1959
GKF N Q A NFD + +L +F +
Sbjct: 962 GKFYSCTDLSKVTHEECQGFFLKHMENSLQDTVLAERMWLNSDFNFDNVLYGMLALFTVS 1021
Query: 1960 TGEDWNTVMYHGIES----FGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
T E W ++Y I+S G V V V I++IV I + ++N+F+ +
Sbjct: 1022 TIEGWPELLYRAIDSDKEDMGPVFNNRVDVSIFFIVYIILIAFFMMNIFVGFVI 1075
>gi|508185|emb|CAA84348.1| voltage-dependent L-type Ca channel alpha 1
subunit [Homo sapiens]
Length = 2139
Score = 909 bits (2350), Expect = 0.0
Identities = 467/838 (55%), Positives = 598/838 (70%), Gaps = 20/838 (2%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
RPR +SE+ P+P+AS+ FI S N FR+ C+ +VN + FTN +LF IL+SS L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP+Q S RN IL DY FTS+FT+EI LK+ +G HKGSFCRN FN+LD+LVV
Sbjct: 918 AAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVV 977
Query: 2626 AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTF 2805
+VSL SF +++ A++ AINRAKGLKHVVQCV VA++TIGNI++VT
Sbjct: 978 SVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 1037
Query: 2806 MLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFN 2985
+LQFMFA IGVQLFKG + C+D SK TEAEC+G YI Y+DG+ P+ + R W N+ F+
Sbjct: 1038 LLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFD 1097
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXX 3165
FDNV AM++LF VSTFEGWP+LLY +IDS+ EDKGPI+N R +++
Sbjct: 1098 FDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFM 1157
Query: 3166 XXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVT 3345
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N+ QY+VW+ V
Sbjct: 1158 MNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVN 1217
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FEY++F++I++NT+ LA +HY S F+ +++ N++FTG+F E +LK++A PK+
Sbjct: 1218 STYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKH 1277
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGG------------TNLISINFFRLFRVMRLV 3669
Y D WN FD L+VVGS +DI ++NP + ISI FFRLFRVMRLV
Sbjct: 1278 YFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLV 1337
Query: 3670 KLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNN 3849
KLLSRGEGIRTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL+D+T I+RNN
Sbjct: 1338 KLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNN 1397
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FP A+L+LFR ATGEAWQDIML+C + +C P S+ + E+ CG++FA
Sbjct: 1398 NFQTFPQAVLLLFRCATGEAWQDIMLACMPGK--KCAPESEPSNSTE-GETPCGSSFAVF 1454
Query: 4030 YFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKH 4209
YFISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+W+EYDP+AKGRIKH
Sbjct: 1455 YFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKH 1514
Query: 4210 LDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYT 4389
LDVVTLLR+I PPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFALVRT L+
Sbjct: 1515 LDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRETE 1574
Query: 4390 EGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQD------- 4548
+ + + S ++R K +H P + + + + +T ++D
Sbjct: 1575 LSSQVQYQAKEASLLERRRKSSH--------PKSSTKPNKLLSSGGSTGWVEDARALEGQ 1626
Query: 4549 -YFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDE 4719
R +E + P P + QAGLRTLH+IGPE++RAISG+L + D+
Sbjct: 1627 VLARGCGWLGSLEERERGPHHPP--LGFQAGLRTLHDIGPEIRRAISGDLTAEEELDK 1682
Score = 722 bits (1863), Expect = 0.0
Identities = 383/698 (54%), Positives = 459/698 (64%), Gaps = 28/698 (4%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXX-XXXNNPIRKLCISIVEWKPFEFLILFMICANCIA 312
+KR KP +Q + NPIR+ CISIVEWKPFE +IL I ANC+A
Sbjct: 81 RKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVA 140
Query: 313 LAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDF 492
LAIY P+P DS+ N+ LE +EY+F+++FT+E LK++A G +FHP+AYLRN WN+LDF
Sbjct: 141 LAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDF 200
Query: 493 IIVVIGLVSTILSKMSIQ-----------GFDVKALRAFRVLRPLRLVSGVPSLQVVLNA 639
IIVV+GL S IL + + GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+
Sbjct: 201 IIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNS 260
Query: 640 ILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPA--TGQLAQKDPTPCGTDT 813
I++AM+PLLHIALLVLFVI+IYAIIGLELF GK+H TC + A+ DP+PC +T
Sbjct: 261 IIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALET 320
Query: 814 EGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDV 993
G +CQ + ++ G W GP +GITNFDNF AMLTVFQC+++EGWTDV
Sbjct: 321 -GHGRQCQ-NGTVCKPG----------WDGPKHGITNFDNFAFAMLTVFQCITMEGWTDV 368
Query: 994 MYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQ 1173
+YWVNDAVGR+WPWIYFVTL+I+GSFFVLNLVLGVLSGEFSKEREKA+ARG FQK REKQ
Sbjct: 369 LYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 428
Query: 1174 QLEEDLKGYLDWITQAEDIEPVNEDEQEDE--------PVAQTXXXXXXXXXXXXXXXXX 1329
QLEEDLKGYLDWITQAEDI+P NEDE DE P ++T
Sbjct: 429 QLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGEN 488
Query: 1330 XPSKWAARMKRLE------KLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQ 1491
++ A R+ + + + N VKS FYW SEHY Q
Sbjct: 489 CGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQ 548
Query: 1492 SEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYF 1671
WL Q AN + LF+ EMLLKMYSLG Y S FNRFDCFVV ILE +LV
Sbjct: 549 PNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+M PLG+SVLR RLLRIFK+T+YW
Sbjct: 609 KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668
Query: 1852 GMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGV 2031
GMQ+FGGKFNF+ Q + R+ FD F Q+LLTVFQILTGEDWN+VMY GI ++GG G+
Sbjct: 669 GMQLFGGKFNFDEMQTR-RSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGM 727
Query: 2032 IVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNA 2145
+VCIY+I+LFICGNYILLNVFLAIAVDNLADA+SLT+A
Sbjct: 728 LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSA 765
Score = 131 bits (329), Expect = 2e-28
Identities = 100/342 (29%), Positives = 162/342 (47%), Gaps = 10/342 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V NN R C IV F LILF I + I+L
Sbjct: 858 RPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL 917
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P Q + ++N +L +YVF +FT+E +LK+ A G H ++ RN +NILD +
Sbjct: 918 AAEDP--VQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLL 975
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S + +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 976 VVSVSLISFGIQSSAINV--VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIV 1033
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ-KDPTPCGTDTEGSAFKCQPSDSL 852
++ + ++A IG++LF GKL+ TC D + A+ K D E QP
Sbjct: 1034 IVTTLLQFMFACIGVQLFKGKLY-TCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRS-- 1090
Query: 853 TNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWP 1032
WE N +FDN AM+ +F + EGW +++Y D+ +
Sbjct: 1091 ------WE-----------NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKG 1133
Query: 1033 WIY---------FVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
IY F+ +I+ +FF++N+ +G + F ++ E+
Sbjct: 1134 PIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1175
Score = 95.9 bits (237), Expect = 1e-17
Identities = 64/259 (24%), Positives = 124/259 (47%), Gaps = 5/259 (1%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S F +++ ++ +NT+++A +HY + D N +F E +LK+ +L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD VV G ++ + + + I+ R R++R+ K+ +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL--VETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + + S +++ + LL+ L I++++GMQ F GK D+ + R + F +FP ++
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT--RRSTFDNFPQSL 696
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNF----AYPYFISF 4044
L +F+ TGE W +M D G G +F YFI
Sbjct: 697 LTVFQILTGEDWNSVMY--------------DGIMAYG------GPSFPGMLVCIYFIIL 736
Query: 4045 FMLCSFLVINLFVAVIMDN 4101
F+ +++++N+F+A+ +DN
Sbjct: 737 FICGNYILLNVFLAIAVDN 755
Score = 90.9 bits (224), Expect = 3e-16
Identities = 88/353 (24%), Positives = 148/353 (40%), Gaps = 54/353 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACK-HYPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE +I L I N V+LA +P S L+ +F +F EA LK++A
Sbjct: 124 KPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGL 183
Query: 3511 -LNPKNYISDRWNVFD-LLVVVGSFIDITYGKLNPGGTNLIS-------INFFRLFRVMR 3663
+P Y+ + WN+ D ++VVVG F I G N + + R FRV+R
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLR 243
Query: 3664 LVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQ-FFGKV--------- 3813
++L+S ++ +L + +K+ L ++ALL++ + IYA+IG++ F GK+
Sbjct: 244 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEG 303
Query: 3814 -----ALDDSTSI------------------------HRNNNFHSFPAAILVLFRSATGE 3906
A DD + H NF +F A+L +F+ T E
Sbjct: 304 IADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITME 363
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVA 4086
W D++ +D G ++ + YF++ ++ SF V+NL +
Sbjct: 364 GWTDVLYWVND---------------------AVGRDWPWIYFVTLIIIGSFFVLNLVLG 402
Query: 4087 VIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
V+ F G + +R + + D KG +LD +T I P
Sbjct: 403 VLSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG---YLDWITQAEDIDP 449
Score = 89.0 bits (219), Expect = 1e-15
Identities = 77/282 (27%), Positives = 122/282 (42%), Gaps = 29/282 (10%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR--NMILNYF 2502
+L L+ N R C +V F +L I + LA P + + N L
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL----RTDAMS 2670
+Y F +FTVE LKVI +GL+FH ++ RN +NLLD ++V V L S +L + D +
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 2671 XXXXXXXXXXXXXXXA---------INRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
A ++ L+ V+ +I A+ + +I L+ + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 2824 AIIGVQLFKGTFF-LCNDLSKMTE-------AECRGEYIH---YEDGDPTKPVSKKRVW- 2967
AIIG++LF G C + + + + C E H ++G KP W
Sbjct: 283 AIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKP-----GWD 337
Query: 2968 --SNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEED 3087
+ NFDN AM+++F T EGW +LY D+ D
Sbjct: 338 GPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRD 379
Score = 82.8 bits (203), Expect = 9e-14
Identities = 73/315 (23%), Positives = 130/315 (41%), Gaps = 33/315 (10%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+L+ +I N I LA+ Q Y Q +K + + +F +FT+E +LK++A F
Sbjct: 1221 FEYLMFVLILLNTICLAM-QHY-GQSCLFK-IAMNILNMLFTGLFTVEMILKLIA----F 1273
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMSI---------------QGFDVKALRAFRV 582
P Y +AWN D +IVV +V +++++ + R FRV
Sbjct: 1274 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRV 1333
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
+R ++L+S ++ +L +++ L ++ALL++ + IYA+IG+++F
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF----------- 1382
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
G++A D T N NF F
Sbjct: 1383 --GKIALNDTTEI------------------------------------NRNNNFQTFPQ 1404
Query: 943 AMLTVFQCVSLEGWTDVMYWV------------------NDAVGREWPWIYFVTLVILGS 1068
A+L +F+C + E W D+M G + YF++ +L +
Sbjct: 1405 AVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCA 1464
Query: 1069 FFVLNLVLGVLSGEF 1113
F ++NL + V+ F
Sbjct: 1465 FLIINLFVAVIMDNF 1479
Score = 69.7 bits (169), Expect = 8e-10
Identities = 55/240 (22%), Positives = 96/240 (39%), Gaps = 27/240 (11%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HYGQS + N+ F LF++EM+LK+ + Y +N FD +V+ SI++
Sbjct: 1239 QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDI 1298
Query: 1657 VLVYFDLMKP--------------LGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXX 1794
+ + + + ++ R R++R+ K+
Sbjct: 1299 AITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQ 1358
Query: 1795 XXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDW 1974
GMQVFG + + NF TF QA+L +F+ TGE W
Sbjct: 1359 ALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAW 1418
Query: 1975 NTVMYHGI-------ESFGGVGTLGVIVC------IYYIVLFICGNYILLNVFLAIAVDN 2115
+M + ES T G C Y+I ++ ++++N+F+A+ +DN
Sbjct: 1419 QDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDN 1478
Score = 43.1 bits (100), Expect = 0.077
Identities = 47/240 (19%), Positives = 88/240 (36%), Gaps = 38/240 (15%)
Frame = +1
Query: 1504 DHFQTMANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYF 1671
+H A+ F +F++E++LKM + G ++ + FN D VV S++ F +
Sbjct: 930 NHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS 989
Query: 1672 DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1851
+ V +LR R+LR +
Sbjct: 990 AINV---VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACI 1046
Query: 1852 GMQVFGGKFNFNPQQPK------------------------PRA------NFDTFVQALL 1941
G+Q+F GK K PR+ +FD + A++
Sbjct: 1047 GVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMM 1106
Query: 1942 TVFQILTGEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
+F + T E W ++Y I+S G + V + I++I+ I + ++N+F+ +
Sbjct: 1107 ALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1166
>gi|116407|sp|P22316|CCAS_CYPCA Dihydropyridine-sensitive L-type,
skeletal muscle calcium channel alpha-1 subunit
gi|7447634|pir||A37860 calcium channel protein alpha-1 chain,
skeletal muscle - common carp
gi|213050|gb|AAA49205.1| calcium channel alpha-1 subunit
Length = 1852
Score = 904 bits (2337), Expect = 0.0
Identities = 514/1115 (46%), Positives = 675/1115 (60%), Gaps = 41/1115 (3%)
Frame = +1
Query: 2260 SARPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSA 2439
S RPR M+++ TV PI +ASS FI + FR C+ +VNH+ FTN +L IL+SS
Sbjct: 771 SPRPRPMADLQLKETVVPIAEASSFFIFGPQHKFRKLCHRIVNHTTFTNIILLFILLSSI 830
Query: 2440 MLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDIL 2619
LAAEDP+ S RN +L Y D FT+VFT+EI LK+ V+G H GSFCRN+FN+LD++
Sbjct: 831 SLAAEDPIDPRSFRNKVLAYADIVFTTVFTIEIVLKMTVYGAFLHTGSFCRNSFNILDLI 890
Query: 2620 VVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLV 2799
VV VSL S + + +S AINRAKGLKHVVQC+ VA+KTIGNI+LV
Sbjct: 891 VVGVSLLSMGMESSTISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAIKTIGNIVLV 950
Query: 2800 TFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNND 2979
T +L FMFA IGVQLFKG + C D + T EC+G ++ + +R+W N+D
Sbjct: 951 TMLLDFMFACIGVQLFKGKLYYCTDPLQKTAEECQGTFLKHVPNSLHDIEVHQRMWVNSD 1010
Query: 2980 FNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXX 3159
FNFDNV + M++LF +STFEGWP++LY AIDSN D GP++N+R +++
Sbjct: 1011 FNFDNVLNGMLALFTISTFEGWPEILYKAIDSNAVDTGPLYNNRVGISIFFIIYIIIIAF 1070
Query: 3160 XXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWF 3339
GFVIVTFQ +GE+EY++CELDKNQR+C+++ALKA+P + YIP+N QYRVW+F
Sbjct: 1071 FMMNIFVGFVIVTFQKQGEQEYKDCELDKNQRQCVQYALKARPLKCYIPKNPHQYRVWYF 1130
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
VTS FEY++F +I++NT+ L +H S D NLIFT +F E ++K++A
Sbjct: 1131 VTSCYFEYLMFFLIMLNTLCLGIQHCNQSDHITKLSDTLNLIFTVLFTGEMIVKLIAFKA 1190
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNP-----GGT-------------------NL- 3624
K Y D WNVFD ++VVGS +D+ +++ GG N+
Sbjct: 1191 KGYFGDPWNVFDFIIVVGSIVDVVLSEVDAALEARGGLWCLHGCAEVNPMQAIAEAENVR 1250
Query: 3625 ISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF 3804
+SI FFRLFRV+RL+KLL+R EGIR LLWTF+KSFQALP+V LLIV+LFFIYAVIGMQ F
Sbjct: 1251 VSITFFRLFRVLRLIKLLNRSEGIRNLLWTFIKSFQALPHVGLLIVMLFFIYAVIGMQMF 1310
Query: 3805 GKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHK 3984
GKVAL D T I+RNNNF +FP A+L+LFR ATGE W ++L+ + CD SD Y
Sbjct: 1311 GKVALVDGTEINRNNNFQTFPQAVLLLFRVATGEQWPKVILASMYGK--LCDAKSD-YGP 1367
Query: 3985 GGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVR 4164
G E CG++ A YF+SF++LC+FL+INLFVA+IMDN DYLTRDWSILGPHHL+EF +
Sbjct: 1368 G--EEYTCGSSIAVFYFLSFYILCAFLIINLFVAIIMDNVDYLTRDWSILGPHHLDEFKK 1425
Query: 4165 LWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFN 4344
+W+EYDP+A GRIKHLDVVTLLR+I PPLGFGK CPHR ACKRL+SMNMPLNSDGTV FN
Sbjct: 1426 IWAEYDPEATGRIKHLDVVTLLRRIQPPLGFGKFCPHRSACKRLISMNMPLNSDGTVTFN 1485
Query: 4345 ATLFALVRTNLKIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKF 4524
ATLFALVRT LKI TEGN ++ANE+LR+ IK IWKRT LLD+V+PP G ED+VTVGKF
Sbjct: 1486 ATLFALVRTALKIKTEGNFEQANEELRAIIKSIWKRTSMKLLDQVIPPIG-EDEVTVGKF 1544
Query: 4525 YATFLIQDYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTL-HEIGPELKRAISGNLET 4701
YATFLIQ++FR+F +R+E E G P + A ++AGLR++ E PEL RAISG+L
Sbjct: 1545 YATFLIQEHFRKFMQRQE-EYYGYRPTK-KNADEIKAGLRSIEEEAAPELHRAISGDLIA 1602
Query: 4702 DFNFDE-----PEPQHRRPHSLFNNLVHRLSGAGSKSPTEHERIEKGSTLLPFQPRSFSP 4866
+ + + E +RR LF L P S P
Sbjct: 1603 EDDMERALEAGEEGIYRRTGGLFG--------------------------LHTDPFSSEP 1636
Query: 4867 THSLAGAEGSPVPSQMHRGAPIN------QSINLPPVNGSARRLPALPPYANHIHDETDD 5028
+ SP+ +QM P+ + I PP + P + ++
Sbjct: 1637 S--------SPLSTQMTSQRPLQFVETRLEDIESPPDSVFLPNTEFFPDNMPTTTNTNNN 1688
Query: 5029 GPRYRDTGDRAGYDQSSRMVVANRNLPVDPDEEEQWMRSGGPSNRSDRRNPHLREPMLVX 5208
D R ++ S A RN + D GG S+ DRR
Sbjct: 1689 ANFVEDMSSRFTFENESLSAAATRNYSYE-DIRGSSSYVGGASSVDDRR----------- 1736
Query: 5209 XXXXXXXXXMSSEAYEGTYRPVGEGKSVRLPFSSRPVLRPAEDSRPVDRLIGQSL---GL 5379
++ Y +Y P + E S D+LI Q+L GL
Sbjct: 1737 LSDFTVRTNITQFPYNPSYGPSKNQTA-------------TEASPATDKLIQQALRDGGL 1783
Query: 5380 GRYA-DARIVGAARREIEEAYSLGEQEIDLAADSL 5481
A D + V R+E+ EA ++G ++++ A +
Sbjct: 1784 DSLAEDPKFVSVTRKELAEAINIGMEDMEGMAQGI 1818
Score = 617 bits (1590), Expect = e-174
Identities = 317/654 (48%), Positives = 426/654 (64%), Gaps = 13/654 (1%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP RK CI+IVEWKPFE +IL I ANC+ALA++ P P +D++ N LE++EY+F+V+F
Sbjct: 57 NPFRKTCINIVEWKPFEIIILLTIFANCVALAVFLPMPEEDTNNTNLTLESLEYIFLVIF 116
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSI---------QGFD 555
T+EC LKIVA G +FH AYLRN WNILDF+IV +GL + ++ ++ GFD
Sbjct: 117 TLECFLKIVAYGLLFHEGAYLRNCWNILDFVIVFMGLFTLVVDTINTIAGVPTEKGGGFD 176
Query: 556 VKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCG 735
+KALRAFRVLRPLRLVSGVPSLQVV+++IL++M+PL HIALLV F++ IYAI+GLELF
Sbjct: 177 MKALRAFRVLRPLRLVSGVPSLQVVMSSILKSMLPLFHIALLVFFMVHIYAIMGLELFKC 236
Query: 736 KLHSTCIDPATGQLAQKD----PTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPG 903
K+H TC T +A ++ P+PC G +C + + EC + WPG
Sbjct: 237 KMHKTCYYQGTNIIAVREGNEKPSPCAQAGHGR--RCTINGT--------ECRAG--WPG 284
Query: 904 PNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLN 1083
PN GIT+FDN AMLTVFQC++ E WTDV+YW+NDA+G +WPWIYF+TL+++GSFF+LN
Sbjct: 285 PNFGITHFDNSCFAMLTVFQCITTESWTDVLYWINDAMGNDWPWIYFLTLILVGSFFILN 344
Query: 1084 LVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDE 1263
LVLG LSGEF+KERE++R+RG +QK RE+QQ++EDL+GY++WIT AE ++ D
Sbjct: 345 LVLGALSGEFTKEREESRSRGEYQKLRERQQMDEDLEGYMEWITHAEVMD-------GDS 397
Query: 1264 PVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXX 1443
+ R+ R + N VKS+ F W
Sbjct: 398 EALLLLRKDTDSESDSLYQMLDQQVIYFYRLAR--RWNVVLRRKCHVWVKSKFFNWWVLL 455
Query: 1444 XXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFD 1623
EH+ Q+E L FQ AN+ + F++EM++KMY+ G Y S FNRFD
Sbjct: 456 VVLLNTLVIAMEHHNQTEGLTSFQDTANVILLACFTIEMVMKMYAFGPRAYFMSIFNRFD 515
Query: 1624 CFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXX 1803
CFVV ILE +LV ++M PLG+SV+R RLLR+FK+T+YWT
Sbjct: 516 CFVVTIGILEIILVVSNIMTPLGISVMRCIRLLRLFKLTRYWTSLNNLVASLLNSVKSIA 575
Query: 1804 XXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTV 1983
GMQVFGGKFNF P + R+NFD F QAL++VFQ+LTGE+W+++
Sbjct: 576 SLLLLLFLFIVIFALLGMQVFGGKFNF-PDRVIQRSNFDNFPQALISVFQVLTGEEWDSI 634
Query: 1984 MYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNA 2145
MY+GI + GG + G++V IY+I+L++CGN++LLNVFLAIAVDNLA+A+SLT A
Sbjct: 635 MYNGIMAHGGPQSPGILVSIYFIILYVCGNFVLLNVFLAIAVDNLAEAESLTAA 688
Score = 137 bits (346), Expect = 2e-30
Identities = 104/341 (30%), Positives = 167/341 (48%), Gaps = 9/341 (2%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++T V + RKLC IV F +IL I + I+L
Sbjct: 773 RPRPMADLQLKETVVPIAEASSFFIFGPQHKFRKLCHRIVNHTTFTNIILLFILLSSISL 832
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P + ++N +L + VF VFTIE VLK+ G H ++ RN++NILD I
Sbjct: 833 AAEDPIDPRS--FRNKVLAYADIVFTTVFTIEIVLKMTVYGAFLHTGSFCRNSFNILDLI 890
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S + +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 891 VVGVSLLSMGMESSTIS--VVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAIKTIGNIV 948
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLT 855
L+ + + ++A IG++LF GKL+ C DP QK C +G+ K P +SL
Sbjct: 949 LVTMLLDFMFACIGVQLFKGKLY-YCTDP-----LQKTAEEC----QGTFLKHVP-NSLH 997
Query: 856 NMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDA------- 1014
++ V N+ + NFDN ML +F + EGW +++Y D+
Sbjct: 998 DIEVHQRMWVNSDF--------NFDNVLNGMLALFTISTFEGWPEILYKAIDSNAVDTGP 1049
Query: 1015 --VGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
R I+F+ +I+ +FF++N+ +G + F K+ E+
Sbjct: 1050 LYNNRVGISIFFIIYIIIIAFFMMNIFVGFVIVTFQKQGEQ 1090
Score = 111 bits (278), Expect = 2e-22
Identities = 76/271 (28%), Positives = 133/271 (49%), Gaps = 1/271 (0%)
Frame = +1
Query: 3292 RRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFT 3471
RR+ R + VW V S+ F + + L++++NT+ +A +H+ + G F D N+I
Sbjct: 430 RRWNVVLRRKCHVW--VKSKFFNWWVLLVVLLNTLVIAMEHHNQTEGLTSFQDTANVILL 487
Query: 3472 GVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLF 3651
F E V+K+ A P+ Y +N FD VV ++I N + I+ R
Sbjct: 488 ACFTIEMVMKMYAFGPRAYFMSIFNRFDCFVVTIGILEIILVVSNI--MTPLGISVMRCI 545
Query: 3652 RVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFG-KVALDDS 3828
R++RL KL + L+ + + S +++ + LL+ L I+A++GMQ FG K D
Sbjct: 546 RLLRLFKLTRYWTSLNNLVASLLNSVKSIASLLLLLFLFIVIFALLGMQVFGGKFNFPDR 605
Query: 3829 TSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRC 4008
+ + +NF +FP A++ +F+ TGE W IM + H G +
Sbjct: 606 --VIQRSNFDNFPQALISVFQVLTGEEWDSIMYN------------GIMAHGG----PQS 647
Query: 4009 GNNFAYPYFISFFMLCSFLVINLFVAVIMDN 4101
YFI ++ +F+++N+F+A+ +DN
Sbjct: 648 PGILVSIYFIILYVCGNFVLLNVFLAIAVDN 678
Score = 85.1 bits (209), Expect = 2e-14
Identities = 71/285 (24%), Positives = 122/285 (41%), Gaps = 32/285 (11%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRN--MILNYF 2502
SLF + N FR C +V F +L I + LA P+ T N + L
Sbjct: 49 SLFFFTLKNPFRKTCINIVEWKPFEIIILLTIFANCVALAVFLPMPEEDTNNTNLTLESL 108
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXX 2682
+Y F +FT+E LK++ +GL+FH+G++ RN +N+LD ++V + L F L D ++
Sbjct: 109 EYIFLVIFTLECFLKIVAYGLLFHEGAYLRNCWNILDFVIVFMGL--FTLVVDTINTIAG 166
Query: 2683 XXXXXXXXXXXAINRA-------------KGLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
RA L+ V+ ++ ++ + +I L+ F + ++
Sbjct: 167 VPTEKGGGFDMKALRAFRVLRPLRLVSGVPSLQVVMSSILKSMLPLFHIALLVFFMVHIY 226
Query: 2824 AIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSK--------------KR 2961
AI+G++LFK C + K + E + P ++ +
Sbjct: 227 AIMGLELFK-----CK-MHKTCYYQGTNIIAVREGNEKPSPCAQAGHGRRCTINGTECRA 280
Query: 2962 VWSNNDF---NFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEED 3087
W +F +FDN AM+++F T E W +LY D+ D
Sbjct: 281 GWPGPNFGITHFDNSCFAMLTVFQCITTESWTDVLYWINDAMGND 325
Score = 81.6 bits (200), Expect = 2e-13
Identities = 51/182 (28%), Positives = 90/182 (49%), Gaps = 28/182 (15%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+L+ F+I N + L I SD+ L +T+ +F V+FT E ++K++A F
Sbjct: 1136 FEYLMFFLIMLNTLCLGIQH---CNQSDHITKLSDTLNLIFTVLFTGEMIVKLIA----F 1188
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMS-----------IQG--------------- 549
Y + WN+ DFIIVV +V +LS++ + G
Sbjct: 1189 KAKGYFGDPWNVFDFIIVVGSIVDVVLSEVDAALEARGGLWCLHGCAEVNPMQAIAEAEN 1248
Query: 550 --FDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLE 723
+ R FRVLR ++L++ ++ +L +++ L H+ LL++ + IYA+IG++
Sbjct: 1249 VRVSITFFRLFRVLRLIKLLNRSEGIRNLLWTFIKSFQALPHVGLLIVMLFFIYAVIGMQ 1308
Query: 724 LF 729
+F
Sbjct: 1309 MF 1310
Score = 75.9 bits (185), Expect = 1e-11
Identities = 83/343 (24%), Positives = 139/343 (40%), Gaps = 19/343 (5%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
N +R+ C V+ K F + +L ++ N + +A+ ++ + +T + +
Sbjct: 433 NVVLRRKCHVWVKSKFFNWWVLLVVLLNTLVIAMEHH---NQTEGLTSFQDTANVILLAC 489
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG-FDVKALRAF 576
FTIE V+K+ A G P AY + +N D +V IG++ IL +I + +R
Sbjct: 490 FTIEMVMKMYAFG----PRAYFMSIFNRFDCFVVTIGILEIILVVSNIMTPLGISVMRCI 545
Query: 577 RVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI 756
R+LR +L SL ++ ++L ++ IA L+L + L I L
Sbjct: 546 RLLRLFKLTRYWTSLNNLVASLLNSV---KSIASLLLLLFLFIVIFAL------------ 590
Query: 757 DPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNF 936
G G F +P +NFDNF
Sbjct: 591 --------------LGMQVFGGKFN---------------------FPDRVIQRSNFDNF 615
Query: 937 GLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPW-------IYFVTLVILGSFFVLNLVLG 1095
A+++VFQ ++ E W +MY N + P IYF+ L + G+F +LN+ L
Sbjct: 616 PQALISVFQVLTGEEWDSIMY--NGIMAHGGPQSPGILVSIYFIILYVCGNFVLLNVFLA 673
Query: 1096 V-----------LSGEFSKEREKARARGLFQKFREKQQLEEDL 1191
+ + + K EKAR R L + EK + E+ L
Sbjct: 674 IAVDNLAEAESLTAAQKEKAEEKAR-RKLMRTLPEKSEEEKAL 715
Score = 68.9 bits (167), Expect = 1e-09
Identities = 68/309 (22%), Positives = 123/309 (39%), Gaps = 57/309 (18%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLAC---KHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVA--- 3510
+ FE +I L I N V+LA + L+ IF +F E LKIVA
Sbjct: 70 KPFEIIILLTIFANCVALAVFLPMPEEDTNNTNLTLESLEYIFLVIFTLECFLKIVAYGL 129
Query: 3511 -LNPKNYISDRWNVFDLLVVVGSFIDITYGKLNP---------GGTNLISINFFRLFRVM 3660
+ Y+ + WN+ D ++V + +N GG ++ ++ R FRV+
Sbjct: 130 LFHEGAYLRNCWNILDFVIVFMGLFTLVVDTINTIAGVPTEKGGGFDMKAL---RAFRVL 186
Query: 3661 RLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF----GKVALDDS 3828
R ++L+S ++ ++ + +KS L ++ALL+ + IYA++G++ F K
Sbjct: 187 RPLRLVSGVPSLQVVMSSILKSMLPLFHIALLVFFMVHIYAIMGLELFKCKMHKTCYYQG 246
Query: 3829 TSI--HRNNNFHSFPA-----------------------------------AILVLFRSA 3897
T+I R N P A+L +F+
Sbjct: 247 TNIIAVREGNEKPSPCAQAGHGRRCTINGTECRAGWPGPNFGITHFDNSCFAMLTVFQCI 306
Query: 3898 TGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINL 4077
T E+W D++ +D GN++ + YF++ ++ SF ++NL
Sbjct: 307 TTESWTDVLYWIND---------------------AMGNDWPWIYFLTLILVGSFFILNL 345
Query: 4078 FVAVIMDNF 4104
+ + F
Sbjct: 346 VLGALSGEF 354
Score = 68.2 bits (165), Expect = 2e-09
Identities = 59/252 (23%), Positives = 102/252 (40%), Gaps = 38/252 (15%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+H QS+ + NL F +LF+ EM++K+ + Y +N FD +V+ SI++
Sbjct: 1154 QHCNQSDHITKLSDTLNLIFTVLFTGEMIVKLIAFKAKGYFGDPWNVFDFIIVVGSIVDV 1213
Query: 1657 VLVYFDL----------------MKPL-----------GVSVLRSARLLRIFKVTKYWTX 1755
VL D + P+ ++ R R+LR+ K+
Sbjct: 1214 VLSEVDAALEARGGLWCLHGCAEVNPMQAIAEAENVRVSITFFRLFRVLRLIKLLNRSEG 1273
Query: 1756 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQA 1935
GMQ+FG + + NF TF QA
Sbjct: 1274 IRNLLWTFIKSFQALPHVGLLIVMLFFIYAVIGMQMFGKVALVDGTEINRNNNFQTFPQA 1333
Query: 1936 LLTVFQILTGEDWNTVMYHGI-------ESFGGVG---TLGVIVCIYYIVLF-ICGNYIL 2082
+L +F++ TGE W V+ + +S G G T G + ++Y + F I +++
Sbjct: 1334 VLLLFRVATGEQWPKVILASMYGKLCDAKSDYGPGEEYTCGSSIAVFYFLSFYILCAFLI 1393
Query: 2083 LNVFLAIAVDNL 2118
+N+F+AI +DN+
Sbjct: 1394 INLFVAIIMDNV 1405
Score = 61.6 bits (148), Expect = 2e-07
Identities = 55/251 (21%), Positives = 104/251 (40%), Gaps = 9/251 (3%)
Frame = +1
Query: 2371 CNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANS------TRNMILNYFDYFFTSVFTV 2532
C++ V +F VL +L+++ ++A E Q T N+IL + FT+
Sbjct: 440 CHVWVKSKFFNWWVLLVVLLNTLVIAMEHHNQTEGLTSFQDTANVIL-------LACFTI 492
Query: 2533 EITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXX 2712
E+ +K+ FG ++ + FN D VV + + +L +
Sbjct: 493 EMVMKMYAFG----PRAYFMSIFNRFDCFVVTIGILEIILVVSNIMTPLGISVMRCIRLL 548
Query: 2713 XAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSK 2883
+ L ++V ++ +VK+I +++L+ F+ +FA++G+Q+F G F
Sbjct: 549 RLFKLTRYWTSLNNLVASLLNSVKSIASLLLLLFLFIVIFALLGMQVFGGKF-------- 600
Query: 2884 MTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYV 3063
P + + + NFDN A+IS+F V T E W ++Y
Sbjct: 601 ---------------NFPDRVIQRS--------NFDNFPQALISVFQVLTGEEWDSIMYN 637
Query: 3064 AIDSNEEDKGP 3096
I ++ + P
Sbjct: 638 GIMAHGGPQSP 648
Score = 41.2 bits (95), Expect = 0.29
Identities = 49/234 (20%), Positives = 84/234 (34%), Gaps = 38/234 (16%)
Frame = +1
Query: 1522 ANLFFVILFSMEMLLKMYSLGFTTYTTS----QFNRFDCFVVISSILEFVLVYFDLMKPL 1689
A++ F +F++E++LKM G +T S FN D VV S+L + +
Sbjct: 851 ADIVFTTVFTIEIVLKMTVYGAFLHTGSFCRNSFNILDLIVVGVSLLSMGMESSTISV-- 908
Query: 1690 GVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFG 1869
V +LR R+LR + G+Q+F
Sbjct: 909 -VKILRVLRVLRPLRAINRAKGLKHVVQCMFVAIKTIGNIVLVTMLLDFMFACIGVQLFK 967
Query: 1870 GKFNF--NPQQPKPRA----------------------------NFDTFVQALLTVFQIL 1959
GK + +P Q NFD + +L +F I
Sbjct: 968 GKLYYCTDPLQKTAEECQGTFLKHVPNSLHDIEVHQRMWVNSDFNFDNVLNGMLALFTIS 1027
Query: 1960 TGEDWNTVMYHGIES----FGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
T E W ++Y I+S G + V + I++I+ I + ++N+F+ +
Sbjct: 1028 TFEGWPEILYKAIDSNAVDTGPLYNNRVGISIFFIIYIIIIAFFMMNIFVGFVI 1081
>gi|11279256|pir||T43048 calcium channel alpha-1 chain - Cyanea
capillata
gi|1947096|gb|AAC63050.1| voltage-gated calcium channel alpha-1
subunit [Cyanea capillata]
Length = 1911
Score = 899 bits (2324), Expect = 0.0
Identities = 512/1144 (44%), Positives = 685/1144 (59%), Gaps = 42/1144 (3%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVK-PIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAM 2442
RP R+SE+ + P+P SS FI S N R C + + F N++L I++SS
Sbjct: 826 RPLRLSELNLLKDIPDPMPPESSFFIFSANNKLRYLCYRLAVNKIFINSILVLIIMSSVA 885
Query: 2443 LAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILV 2622
LAAEDP+ + RN IL YFD FFT++FT E+T+K+I FG++ HK SFCR+ FN LD+++
Sbjct: 886 LAAEDPIGRDVLRNKILGYFDIFFTAMFTFEVTVKMIAFGVILHKRSFCRSFFNQLDLVI 945
Query: 2623 VAVSLTSFVL-RTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLV 2799
VAVS + +L R A S AINRAKGLKHVVQCV +A+K+IGNIM+V
Sbjct: 946 VAVSWAAIMLSRGSATSVVRILRVLRVLRPLRAINRAKGLKHVVQCVFLAIKSIGNIMIV 1005
Query: 2800 TFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNND 2979
T + QF+FA+IG+QLFKGTFF C D SKMT EC+G + Y + + PV R W +
Sbjct: 1006 TLLFQFLFAVIGIQLFKGTFFYCTDRSKMTAEECKGTFNSYPEVNLANPVVAARTWEKHT 1065
Query: 2980 FNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXX 3159
F FDNV A +SLFVV TFEGWP +L +IDS ++GP N+R VA+
Sbjct: 1066 FRFDNVFQAYLSLFVVMTFEGWPSILEHSIDSTTVNQGPKFNNRPFVAIYYVIYIIIIAF 1125
Query: 3160 XXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWF 3339
GFVIVTFQNEGE E+ +CELDKNQRKC+E+ L KP R++PR R QY +W
Sbjct: 1126 FMINIFVGFVIVTFQNEGEEEFADCELDKNQRKCVEYVLTVKPTYRFVPRKRFQYHIWRV 1185
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
VTSR FEY+IF I+ NT+ LA +++ +S+ +E LD FN+ FT VF E VLK++A N
Sbjct: 1186 VTSRLFEYMIFGFILGNTIVLAAQYHNASKLYERVLDGFNIGFTAVFLLECVLKLMAFNA 1245
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
KNY D WN+FD ++VVGS DI G+++ G I +NFFRLFR +RLVKLLS+G+GIR
Sbjct: 1246 KNYFRDPWNIFDFVIVVGSIADIIIGEISKDGG--IKVNFFRLFRALRLVKLLSQGDGIR 1303
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAIL 3879
TLLWTFMKSFQALP+V LLI+LLFFIYAVIGMQ FG + LD T I+ NNNF +FP A++
Sbjct: 1304 TLLWTFMKSFQALPFVGLLILLLFFIYAVIGMQVFGTIRLDSGTVINSNNNFQTFPQALI 1363
Query: 3880 VLFRSATGEAWQDIMLSCSDREDVRC--DPMSDDYHKGGLNESRCGNNFAYPYFISFFML 4053
VLFRSATGE WQ IM++C + E V+C DP CG +FAY YF+SF+M+
Sbjct: 1364 VLFRSATGENWQQIMMACVNSESVKCEVDP-----------SKTCGTDFAYLYFMSFYMI 1412
Query: 4054 CSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLR 4233
CSFL+INLFVAVIMDNFDYLTRDWSILG HHLEE+VR+W+EYDP+A GR+KH+D+V++L+
Sbjct: 1413 CSFLIINLFVAVIMDNFDYLTRDWSILGAHHLEEYVRIWAEYDPEASGRMKHVDIVSMLK 1472
Query: 4234 KISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIY---TEGNID 4404
+I PPLGFGK CPHR ACKRLVSMNM +N+DGTV F+ATLFALVRT+L I I
Sbjct: 1473 RIEPPLGFGKCCPHREACKRLVSMNMMMNNDGTVDFHATLFALVRTSLNIKKPDATETIL 1532
Query: 4405 EANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEME 4584
AN +LR +K +W RT+++L D+++PP + +TVGKFYATFLIQ+YFR+FKK+++ E
Sbjct: 1533 HANNELRGILKHLWPRTNENLFDKLIPPPDYAEGITVGKFYATFLIQEYFRKFKKKRQEE 1592
Query: 4585 AKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNL--ETDFNFDEPEPQHRRPHSLFN 4758
K +AL+AGLRTL E+GP++KRAISG+L E +E E + + HS
Sbjct: 1593 RK---KKNADSTVALKAGLRTLQELGPKIKRAISGDLMEEGTKEEEEKEKEPNKRHSFMA 1649
Query: 4759 NLVHRL--SGAGSKSPTEHERIEKGSTLLPFQPRSFSPTHSLAGAEGSPVPSQMHRGAPI 4932
L + S AG K + + + P Q +PT S++ H AP
Sbjct: 1650 GLRKGIISSFAGDKKRNSYYNALQDT---PKQTPKQTPTSSVS-----------HLAAPN 1695
Query: 4933 NQSINLPPVNGSARRLPALPPYANHIHDETDDG-------------PRYRDTGDRAGYDQ 5073
Q G LP+L N D G PR + G R +
Sbjct: 1696 TQ--------GKRISLPSLQTKTNSSQDNIPRGALHEGPSIMQRLSPRLKRKGQR---PK 1744
Query: 5074 SSRMVVANRNLPVDPDEEEQWMRSGGPSNRSDRRNPHLREPMLVXXXXXXXXXXMSSEAY 5253
S+ + + D ++ + S++SD NP ++ SS
Sbjct: 1745 STPFEI------IHHDSDDLALPQIVLSSQSDVSNPSSKD----------RDNSRSSTPQ 1788
Query: 5254 EGTYRPVGEGKSVRLPFSSRPVLRPAEDSRPVDRLIGQSLG-LGRYADARIVGAARREIE 5430
+ P + S L + P S L+GQ+L G D I+ ++E+
Sbjct: 1789 HASSIPGADLNSNLLDSNLGP---RRSRSSSTSSLVGQALAHEGVPQDEAILRTVQKELS 1845
Query: 5431 EAYSLGEQEIDLAADSL-----------------APLMQHVGMHDIRDINENSRSALLRP 5559
++ ++ E +++ AA ++ AP + + N+N+ + RP
Sbjct: 1846 DSLNISESQLEGAARNIIYDFEKESGTSIPPPEAAPPQEQPNAEQLSPYNDNNDNRSSRP 1905
Query: 5560 AENS 5571
S
Sbjct: 1906 DRTS 1909
Score = 624 bits (1609), Expect = e-177
Identities = 341/681 (50%), Positives = 413/681 (60%), Gaps = 12/681 (1%)
Frame = +1
Query: 133 TKKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIA 312
TKK+P + LR + +NP+R I+IV+WKPF+F IL I ANC A
Sbjct: 77 TKKQPGAGQNLRPKRALFCLTL-------DNPVRSAAITIVDWKPFDFFILASIFANCAA 129
Query: 313 LAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDF 492
LA Y+P PA D N LE EY F+ VF IE +LKI+A GF+ HP AYLRN WNILDF
Sbjct: 130 LAAYEPLPAGDMTSTNQDLEVAEYFFLAVFAIEGLLKIIAYGFILHPGAYLRNGWNILDF 189
Query: 493 IIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHI 672
IVVIG S I + GFDVKALRAFRVLRPLRLVSGVPSLQVV+N+I++AM+PL HI
Sbjct: 190 SIVVIGFASMIFEEYLKSGFDVKALRAFRVLRPLRLVSGVPSLQVVMNSIVKAMLPLFHI 249
Query: 673 ALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSL 852
ALLV+FVI+IYAIIG+ELF GKLH TC D T A +P PC T T S + PS S+
Sbjct: 250 ALLVVFVIIIYAIIGVELFTGKLHQTCYDNITNLPASSEPKPCSTTT--SYGRQCPSGSI 307
Query: 853 TNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWP 1032
C +N W GPN GITNFDN LA LTVFQC +LEGWTDV+Y +N+ G WP
Sbjct: 308 --------CKNN--WEGPNYGITNFDNVALAALTVFQCTTLEGWTDVLYDINNVSGGGWP 357
Query: 1033 WIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWI 1212
WIYFVTL+ GSFFVLNL+LGVLSGEF+KE+ + G F K REK L++ +KGYLDWI
Sbjct: 358 WIYFVTLITFGSFFVLNLILGVLSGEFAKEKARQTKSGEFHKIREKHMLDDAVKGYLDWI 417
Query: 1213 TQAEDIE--------PVNEDEQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKWAAR---MK 1359
QA DIE V + E + P+ + K
Sbjct: 418 NQASDIENVTVTQEGAVEPGDSTSERKLSSRRASGISHASSGIYNIAAPNPLTTKERIEK 477
Query: 1360 RLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFV 1539
L K + +VKSQTFYW EHY Q +++ F AN FF+
Sbjct: 478 NLTKFHHRLRRQCRGIVKSQTFYWMVIIAVFLNSLVLAVEHYDQPDYITMFLDRANYFFL 537
Query: 1540 ILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARL 1719
LF+ EMLLK+Y LG Y S FNRFDC VV+SS+LE + P+G+SVLR RL
Sbjct: 538 GLFTFEMLLKIYCLGIYGYLNSLFNRFDCLVVLSSLLEVAITVPTGWPPIGISVLRCVRL 597
Query: 1720 LRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQP 1899
LRIFKVT+YW GMQ+FGG+FN + Q P
Sbjct: 598 LRIFKVTRYWESLSNLVQSLVNSIKSIGSLLLLLSLFILIFSLLGMQIFGGRFNLDEQAP 657
Query: 1900 KPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGV-GTLGVIVCIYYIVLFICGNY 2076
PR NFD+F ++L+TVFQILTGEDWN VMY GI+S+GG+ +I IY++ L I GNY
Sbjct: 658 -PRTNFDSFWRSLITVFQILTGEDWNAVMYVGIQSWGGIKNPSSIIAIIYFVALVIVGNY 716
Query: 2077 ILLNVFLAIAVDNLADADSLT 2139
ILLNVFLAIAVDNLADA+++T
Sbjct: 717 ILLNVFLAIAVDNLADAENMT 737
Score = 114 bits (284), Expect = 4e-23
Identities = 73/265 (27%), Positives = 136/265 (50%), Gaps = 1/265 (0%)
Frame = +1
Query: 3310 NRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFE 3489
+RL+ + V S+ F +++ + + +N++ LA +HY FLD N F G+F FE
Sbjct: 484 HRLRRQCRGIVKSQTFYWMVIIAVFLNSLVLAVEHYDQPDYITMFLDRANYFFLGLFTFE 543
Query: 3490 AVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLV 3669
+LKI L Y++ +N FD LVV+ S +++ P G I I+ R R++R+
Sbjct: 544 MLLKIYCLGIYGYLNSLFNRFDCLVVLSSLLEVAI--TVPTGWPPIGISVLRCVRLLRIF 601
Query: 3670 KLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRN 3846
K+ E + L+ + + S +++ + LL+ L I++++GMQ F G+ LD+
Sbjct: 602 KVTRYWESLSNLVQSLVNSIKSIGSLLLLLSLFILIFSLLGMQIFGGRFNLDEQAP--PR 659
Query: 3847 NNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAY 4026
NF SF +++ +F+ TGE W +M GG+ + A
Sbjct: 660 TNFDSFWRSLITVFQILTGEDWNAVM-------------YVGIQSWGGIKNP--SSIIAI 704
Query: 4027 PYFISFFMLCSFLVINLFVAVIMDN 4101
YF++ ++ +++++N+F+A+ +DN
Sbjct: 705 IYFVALVIVGNYILLNVFLAIAVDN 729
Score = 110 bits (276), Expect = 3e-22
Identities = 86/313 (27%), Positives = 146/313 (46%), Gaps = 9/313 (2%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
NN +R LC + K F IL +I + +ALA P +N +L + F +
Sbjct: 855 NNKLRYLCYRLAVNKIFINSILVLIIMSSVALAAEDPIGRDV--LRNKILGYFDIFFTAM 912
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
FT E +K++A G + H ++ R+ +N LD +IV + + +LS+ S V+ LR R
Sbjct: 913 FTFEVTVKMIAFGVILHKRSFCRSFFNQLDLVIVAVSWAAIMLSRGSATSV-VRILRVLR 971
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPLR ++ L+ V+ + A+ + +I ++ L ++A+IG++LF G C D
Sbjct: 972 VLRPLRAINRAKGLKHVVQCVFLAIKSIGNIMIVTLLFQFLFAVIGIQLFKGTFF-YCTD 1030
Query: 760 PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFG 939
+ + T F P +L N V + TW FDN
Sbjct: 1031 RSKMTAEECKGT----------FNSYPEVNLANPVV-----AARTW---EKHTFRFDNVF 1072
Query: 940 LAMLTVFQCVSLEGWTDVMYWVNDAV---------GREWPWIYFVTLVILGSFFVLNLVL 1092
A L++F ++ EGW ++ D+ R + IY+V +I+ +FF++N+ +
Sbjct: 1073 QAYLSLFVVMTFEGWPSILEHSIDSTTVNQGPKFNNRPFVAIYYVIYIIIIAFFMINIFV 1132
Query: 1093 GVLSGEFSKEREK 1131
G + F E E+
Sbjct: 1133 GFVIVTFQNEGEE 1145
Score = 100 bits (250), Expect = 3e-19
Identities = 77/280 (27%), Positives = 128/280 (45%), Gaps = 12/280 (4%)
Frame = +1
Query: 2257 TSARPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSS 2436
TS P + ++ + PK + LF L+ N R +V+ F +L I +
Sbjct: 69 TSTYPTKKTKKQPGAGQNLRPKRA-LFCLTLDNPVRSAAITIVDWKPFDFFILASIFANC 127
Query: 2437 AMLAAEDPLQAN--STRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLL 2610
A LAA +PL A ++ N L +YFF +VF +E LK+I +G + H G++ RN +N+L
Sbjct: 128 AALAAYEPLPAGDMTSTNQDLEVAEYFFLAVFAIEGLLKIIAYGFILHPGAYLRNGWNIL 187
Query: 2611 DILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXX--XXAINRAKGLKHVVQCVIVAVKTIG 2784
D +V + S + S ++ L+ V+ ++ A+ +
Sbjct: 188 DFSIVVIGFASMIFEEYLKSGFDVKALRAFRVLRPLRLVSGVPSLQVVMNSIVKAMLPLF 247
Query: 2785 NIMLVTFMLQFMFAIIGVQLFKGTFF-LCND----LSKMTEAECRGEYIHYEDGDPTKPV 2949
+I L+ + ++AIIGV+LF G C D L +E + Y P+ +
Sbjct: 248 HIALLVVFVIIIYAIIGVELFTGKLHQTCYDNITNLPASSEPKPCSTTTSYGRQCPSGSI 307
Query: 2950 SKKRVWSNNDF---NFDNVGDAMISLFVVSTFEGWPQLLY 3060
K W ++ NFDNV A +++F +T EGW +LY
Sbjct: 308 CKNN-WEGPNYGITNFDNVALAALTVFQCTTLEGWTDVLY 346
Score = 91.3 bits (225), Expect = 2e-16
Identities = 87/348 (25%), Positives = 152/348 (43%), Gaps = 19/348 (5%)
Frame = +1
Query: 250 IVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIV 429
+V + FE++I I N I LA Y Y+ +L+ F VF +ECVLK++
Sbjct: 1185 VVTSRLFEYMIFGFILGNTIVLAAQ--YHNASKLYER-VLDGFNIGFTAVFLLECVLKLM 1241
Query: 430 AMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG-FDVKALRAFRVLRPLRLVS 606
A F+ Y R+ WNI DF+IVV + I+ ++S G V R FR LR ++L+S
Sbjct: 1242 A----FNAKNYFRDPWNIFDFVIVVGSIADIIIGEISKDGGIKVNFFRLFRALRLVKLLS 1297
Query: 607 GVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQK 786
++ +L +++ L + LL+L + IYA+IG+++F
Sbjct: 1298 QGDGIRTLLWTFMKSFQALPFVGLLILLLFFIYAVIGMQVF------------------- 1338
Query: 787 DPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQC 966
GT +R + S T NN F F A++ +F+
Sbjct: 1339 -----GT-------------------IRLD--SGTVINSNNN----FQTFPQALIVLFRS 1368
Query: 967 VSLEGWTDVMY-WVND-----------AVGREWPWIYFVTLVILGSFFVLNLVLGVLSGE 1110
+ E W +M VN G ++ ++YF++ ++ SF ++NL + V+
Sbjct: 1369 ATGENWQQIMMACVNSESVKCEVDPSKTCGTDFAYLYFMSFYMICSFLIINLFVAVIMDN 1428
Query: 1111 F---SKEREKARARGLFQKFREKQQLEEDLKG---YLDWITQAEDIEP 1236
F +++ A L + R + + + G ++D ++ + IEP
Sbjct: 1429 FDYLTRDWSILGAHHLEEYVRIWAEYDPEASGRMKHVDIVSMLKRIEP 1476
Score = 86.7 bits (213), Expect = 6e-15
Identities = 123/591 (20%), Positives = 205/591 (33%), Gaps = 65/591 (10%)
Frame = +1
Query: 1519 MANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKP 1686
+A FF+ +F++E LLK+ + GF Y + +N D +V+ + + L
Sbjct: 150 VAEYFFLAVFAIEGLLKIIAYGFILHPGAYLRNGWNILDFSIVVIGFASMIFEEY-LKSG 208
Query: 1687 LGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVF 1866
V LR+ R+LR ++ G+++F
Sbjct: 209 FDVKALRAFRVLRPLRLVSGVPSLQVVMNSIVKAMLPLFHIALLVVFVIIIYAIIGVELF 268
Query: 1867 GGKFNFN----------PQQPKPRA---------------------------NFDTFVQA 1935
GK + +PKP + NFD A
Sbjct: 269 TGKLHQTCYDNITNLPASSEPKPCSTTTSYGRQCPSGSICKNNWEGPNYGITNFDNVALA 328
Query: 1936 LLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDN 2115
LTVFQ T E W V+Y I + G G IY++ L G++ +LN+ L +
Sbjct: 329 ALTVFQCTTLEGWTDVLYD-INNVSGGGW----PWIYFVTLITFGSFFVLNLILGVLSGE 383
Query: 2116 LADADSLTNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSA---------- 2265
A + A
Sbjct: 384 FAKEKARQTKSGEFHKIREKHMLDDAVKGYLDWINQASDIENVTVTQEGAVEPGDSTSER 443
Query: 2266 --RPRRMSEVPAAST-----VKPIPKASSLFILSHTNSF----RVFCNMVVNHSYFTNAV 2412
RR S + AS+ P P + I + F R C +V F V
Sbjct: 444 KLSSRRASGISHASSGIYNIAAPNPLTTKERIEKNLTKFHHRLRRQCRGIVKSQTFYWMV 503
Query: 2413 LFCILVSSAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCR 2592
+ + ++S +LA E Q + M L+ +YFF +FT E+ LK+ G+ +
Sbjct: 504 IIAVFLNSLVLAVEHYDQPDYI-TMFLDRANYFFLGLFTFEMLLKIYCLGIY----GYLN 558
Query: 2593 NAFNLLDILVVAVSL--TSFVLRTDAMSXXXXXXXXXXXXXXXAINRA-KGLKHVVQCVI 2763
+ FN D LVV SL + + T + R + L ++VQ ++
Sbjct: 559 SLFNRFDCLVVLSSLLEVAITVPTGWPPIGISVLRCVRLLRIFKVTRYWESLSNLVQSLV 618
Query: 2764 VAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTK 2943
++K+IG+++L+ + +F+++G+Q+F G F L T
Sbjct: 619 NSIKSIGSLLLLLSLFILIFSLLGMQIFGGRFNLDEQAPPRT------------------ 660
Query: 2944 PVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGP 3096
NFD+ ++I++F + T E W ++YV I S K P
Sbjct: 661 -------------NFDSFWRSLITVFQILTGEDWNAVMYVGIQSWGGIKNP 698
Score = 85.5 bits (210), Expect = 1e-14
Identities = 75/297 (25%), Positives = 127/297 (42%), Gaps = 45/297 (15%)
Frame = +1
Query: 3349 RAFEYVIFLIIVMNTVSLACKHYPSSRG----FEDFLDVFNLIFTGVFAFEAVLKIVA-- 3510
+ F++ I I N +LA + P G L+V F VFA E +LKI+A
Sbjct: 113 KPFDFFILASIFANCAALAA-YEPLPAGDMTSTNQDLEVAEYFFLAVFAIEGLLKIIAYG 171
Query: 3511 --LNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSR 3684
L+P Y+ + WN+ D +VV F + + + G + R FRV+R ++L+S
Sbjct: 172 FILHPGAYLRNGWNILDFSIVVIGFASMIFEEYLKSG---FDVKALRAFRVLRPLRLVSG 228
Query: 3685 GEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKV---ALDDST------- 3831
++ ++ + +K+ L ++ALL+V + IYA+IG++ F GK+ D+ T
Sbjct: 229 VPSLQVVMNSIVKAMLPLFHIALLVVFVIIIYAIIGVELFTGKLHQTCYDNITNLPASSE 288
Query: 3832 -----------------SIHRNN---------NFHSFPAAILVLFRSATGEAWQDIMLSC 3933
SI +NN NF + A L +F+ T E W D++
Sbjct: 289 PKPCSTTTSYGRQCPSGSICKNNWEGPNYGITNFDNVALAALTVFQCTTLEGWTDVLYDI 348
Query: 3934 SDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
++ G + + YF++ SF V+NL + V+ F
Sbjct: 349 NNVS---------------------GGGWPWIYFVTLITFGSFFVLNLILGVLSGEF 384
Score = 65.9 bits (159), Expect = 1e-08
Identities = 51/244 (20%), Positives = 97/244 (38%), Gaps = 7/244 (2%)
Frame = +1
Query: 1405 LVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLG 1584
+V S+ F + ++++ S+ + N+ F +F +E +LK+ +
Sbjct: 1185 VVTSRLFEYMIFGFILGNTIVLAAQYHNASKLYERVLDGFNIGFTAVFLLECVLKLMAFN 1244
Query: 1585 FTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXX 1764
Y +N FD +V+ SI + ++ + V+ R R LR+ K+
Sbjct: 1245 AKNYFRDPWNIFDFVIVVGSIADIIIGEISKDGGIKVNFFRLFRALRLVKLLSQGDGIRT 1304
Query: 1765 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLT 1944
GMQVFG + NF TF QAL+
Sbjct: 1305 LLWTFMKSFQALPFVGLLILLLFFIYAVIGMQVFGTIRLDSGTVINSNNNFQTFPQALIV 1364
Query: 1945 VFQILTGEDWNTVMYHGIES------FGGVGTLGV-IVCIYYIVLFICGNYILLNVFLAI 2103
+F+ TGE+W +M + S T G +Y++ ++ +++++N+F+A+
Sbjct: 1365 LFRSATGENWQQIMMACVNSESVKCEVDPSKTCGTDFAYLYFMSFYMICSFLIINLFVAV 1424
Query: 2104 AVDN 2115
+DN
Sbjct: 1425 IMDN 1428
Score = 45.4 bits (106), Expect = 0.016
Identities = 48/233 (20%), Positives = 83/233 (35%), Gaps = 38/233 (16%)
Frame = +1
Query: 1525 NLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLG 1692
++FF +F+ E+ +KM + G ++ S FN+ D +V S +L
Sbjct: 906 DIFFTAMFTFEVTVKMIAFGVILHKRSFCRSFFNQLDLVIVAVSWAAIMLSRGSATSV-- 963
Query: 1693 VSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGG 1872
V +LR R+LR + G+Q+F G
Sbjct: 964 VRILRVLRVLRPLRAINRAKGLKHVVQCVFLAIKSIGNIMIVTLLFQFLFAVIGIQLFKG 1023
Query: 1873 KFNFNPQQPK-------------PRAN-----------------FDTFVQALLTVFQILT 1962
F + + K P N FD QA L++F ++T
Sbjct: 1024 TFFYCTDRSKMTAEECKGTFNSYPEVNLANPVVAARTWEKHTFRFDNVFQAYLSLFVVMT 1083
Query: 1963 GEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
E W +++ H I+S G V IYY++ I + ++N+F+ +
Sbjct: 1084 FEGWPSILEHSIDSTTVNQGPKFNNRPFVAIYYVIYIIIIAFFMINIFVGFVI 1136
>gi|15127838|gb|AAK84312.1| high voltage-activated calcium channel
Cav1 [Schistosoma mansoni]
Length = 1776
Score = 889 bits (2297), Expect = 0.0
Identities = 448/774 (57%), Positives = 564/774 (71%), Gaps = 15/774 (1%)
Frame = +1
Query: 2308 KPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNM 2487
+ +P S+ FI + TN FR+FC+ VV S+F N VL CILVSS +LAAEDPL ANS RN
Sbjct: 786 RTMPPHSAFFIFADTNKFRIFCHNVVCFSHFGNIVLVCILVSSILLAAEDPLHANSPRNR 845
Query: 2488 ILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAM 2667
ILN FDYFFTSVFTVEITLK+I +G V H+G+FCR+ FNLLD++VV V+L SFVL+ +
Sbjct: 846 ILNMFDYFFTSVFTVEITLKMISYGFVLHEGAFCRSVFNLLDLIVVCVALVSFVLQNQTI 905
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
S AINRAKGLKHVVQC+I+A+K+IGNI+LVTF+L+FMFA+IGVQLF
Sbjct: 906 SAVKILRVLRVLRPLRAINRAKGLKHVVQCMIIAIKSIGNIVLVTFLLEFMFAVIGVQLF 965
Query: 2848 KGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVV 3027
KG F+ C D+SK E +C+G++I Y+D P+ +R W N+DFNFDNV +A+++LF V
Sbjct: 966 KGKFYSCTDISKHVEEDCKGQFIEYKDMSLEDPILSEREWKNSDFNFDNVPNALLTLFAV 1025
Query: 3028 STFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIVTFQN 3207
STFEGWP LLY +IDSN ED GPI N R VA GFVIVTFQ
Sbjct: 1026 STFEGWPSLLYRSIDSNAEDHGPITNYRPVVAFFYITFIILIPFFMINIFVGFVIVTFQK 1085
Query: 3208 EGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVM 3387
EGE EY+NCEL+KNQRKCIE+ALKA+P RRYIP+ LQ+++W V S+ FE +IF+ I +
Sbjct: 1086 EGEAEYKNCELNKNQRKCIEYALKARPRRRYIPKGHLQFKIWSVVVSKRFEILIFIFIFI 1145
Query: 3388 NTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVV 3567
NTV+L K+ + LD FN FT VF E +L++ A + ++Y SD NV D ++V
Sbjct: 1146 NTVALMLKYDKQGKLEARILDSFNYFFTAVFTVEFILRLSAFSFRHYFSDIGNVIDFVLV 1205
Query: 3568 VGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYV 3747
+GS+IDI + + S+NFFRLFRVMRL+KLLS+ E IR LLWTF+KS QALPYV
Sbjct: 1206 LGSYIDIIVTQSDISQVK-FSVNFFRLFRVMRLIKLLSKEESIRQLLWTFIKSIQALPYV 1264
Query: 3748 ALLIVLLFFIYAVIGMQFFGKVALDDS-------TSIHRNNNFHSFPAAILVLFRSATGE 3906
ALLI ++FFIYAVIGMQ FG+++++++ ++HRNNNF +F A+LVLFR ATGE
Sbjct: 1265 ALLIAMIFFIYAVIGMQLFGQISIEENPLEEEEWPTLHRNNNFQNFFYALLVLFRCATGE 1324
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVA 4086
+WQDIM++C RE +C S + G CG+ AY YFISF + +FLVINLFVA
Sbjct: 1325 SWQDIMMAC--REGQKCSKDSGETEVNG-----CGSKLAYAYFISFHAISAFLVINLFVA 1377
Query: 4087 VIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKL 4266
VIMDNFDYLTRDWSILGPHHL+EF+ W++YDP+AKGR++HLDVVT+L KISPPLGFG +
Sbjct: 1378 VIMDNFDYLTRDWSILGPHHLDEFITKWADYDPEAKGRVRHLDVVTMLGKISPPLGFGSM 1437
Query: 4267 CPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEG--------NIDEANEQL 4422
CPH AC +LV MNMPLNSDGTV FNATLFALVR NLKI G ++D+ NE+L
Sbjct: 1438 CPHTRACHKLVRMNMPLNSDGTVFFNATLFALVRRNLKIKIPGAEIGEKEKSLDQLNEEL 1497
Query: 4423 RSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEME 4584
R IKRIWKRT LLD+++PP G D VTVGKFYATFLIQ++FR ++KRK ++
Sbjct: 1498 RIVIKRIWKRTSPKLLDQIIPPKG-SDVVTVGKFYATFLIQNWFREWQKRKMIQ 1550
Score = 587 bits (1512), Expect = e-165
Identities = 311/640 (48%), Positives = 407/640 (63%), Gaps = 8/640 (1%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+R++CI IV+ +PFE+ IL I NC+ALA PYP +DS+ N +LE +E F+++F
Sbjct: 64 NPLRRVCICIVDARPFEYFILATILCNCLALAFNHPYPGEDSNAVNQVLEKVELAFVIIF 123
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
T E LKI+A GF+ H AYLRN WN+LDF IV+IGL S L M+I DVKALRAFRV
Sbjct: 124 TTESALKIIAYGFVLHQDAYLRNFWNVLDFSIVLIGLSSKALENMNI---DVKALRAFRV 180
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLRL+SG+PSLQVVLN+I+ AM+PLLHIALLV+FVI++YAI+GLELF KLH TC
Sbjct: 181 LRPLRLLSGLPSLQVVLNSIITAMVPLLHIALLVIFVIIVYAIVGLELFQSKLHLTCYRN 240
Query: 763 ATGQLAQK--DPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSS-----NTTWPGPNNGIT 921
+T ++ + +P PC +T FKC + +G + C+ + GP GI
Sbjct: 241 STHKIPEMTPNPRPCTFETSSMGFKC------SELGPDYFCADMYGKEGERYTGPEGGIV 294
Query: 922 NFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVL 1101
+FDNF +MLTVF C+++EGWT Y+V+DA+G WPWIYFVTL++LGSFFV+NLVLGVL
Sbjct: 295 SFDNFLYSMLTVFVCITMEGWTSTGYYVSDAIGSWWPWIYFVTLMVLGSFFVMNLVLGVL 354
Query: 1102 SGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVAQTX 1281
SGEFSKE+EK LF+K R++++ ++D GY +WI AE++ D++E + +
Sbjct: 355 SGEFSKEKEKIDRTLLFRKERQEKREQQDYLGYKEWIELAEELSDSEGDDKESQDIESVD 414
Query: 1282 XXXXXXXXX-XXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXX 1458
+ + ++RL K + S+ +
Sbjct: 415 GGDGLIEEEPEMHVEEVVKTHCHSTLRRLRKFRKRTRRAVIAFINSRQCFALVIILVFLN 474
Query: 1459 XXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVI 1638
T+EH+ Q EWLD FQ AN+ FV LF+MEM++KM + F+ Y + FNRFD FVVI
Sbjct: 475 TVVLTTEHHNQPEWLDEFQDFANVVFVTLFTMEMVIKMGASXFSDYISKLFNRFDFFVVI 534
Query: 1639 SSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXX 1818
SILE + V L+ P+GVSVLR ARLLRIFK+T+YW
Sbjct: 535 FSILELLFVKSGLLNPMGVSVLRCARLLRIFKLTQYWESLRSLVGKLLKSVRSVASLLLL 594
Query: 1819 XXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGI 1998
GMQ+FGG+FNF + KPRANFD +QA+LTVFQILTGEDWN VMYHG+
Sbjct: 595 LSIFILICSLLGMQLFGGRFNFIAHE-KPRANFDGILQAMLTVFQILTGEDWNEVMYHGM 653
Query: 1999 ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNL 2118
++ GV+V IY+I LFICGNYILLNVFLAIAVDNL
Sbjct: 654 RAYENSPWYGVVV-IYFIFLFICGNYILLNVFLAIAVDNL 692
Score = 136 bits (342), Expect = 7e-30
Identities = 94/311 (30%), Positives = 155/311 (49%), Gaps = 9/311 (2%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
N R C ++V + F ++L I + I LA P A +N +L +Y F VF
Sbjct: 801 NKFRIFCHNVVCFSHFGNIVLVCILVSSILLAAEDPLHANSP--RNRILNMFDYFFTSVF 858
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
T+E LK+++ GF+ H A+ R+ +N+LD I+V + LVS +L +I VK LR RV
Sbjct: 859 TVEITLKMISYGFVLHEGAFCRSVFNLLDLIVVCVALVSFVLQNQTISA--VKILRVLRV 916
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
LRPLR ++ L+ V+ ++ A+ + +I L+ + ++A+IG++LF GK +S C D
Sbjct: 917 LRPLRAINRAKGLKHVVQCMIIAIKSIGNIVLVTFLLEFMFAVIGVQLFKGKFYS-CTDI 975
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
+ D +G + + +M + S W N NFDN
Sbjct: 976 S---------KHVEEDCKGQFIEYK------DMSLEDPILSEREW---KNSDFNFDNVPN 1017
Query: 943 AMLTVFQCVSLEGWTDVMYWVNDAVGREWPWI---------YFVTLVILGSFFVLNLVLG 1095
A+LT+F + EGW ++Y D+ + I +++T +IL FF++N+ +G
Sbjct: 1018 ALLTLFAVSTFEGWPSLLYRSIDSNAEDHGPITNYRPVVAFFYITFIILIPFFMINIFVG 1077
Query: 1096 VLSGEFSKERE 1128
+ F KE E
Sbjct: 1078 FVIVTFQKEGE 1088
Score = 114 bits (286), Expect = 2e-23
Identities = 74/270 (27%), Positives = 135/270 (49%), Gaps = 3/270 (1%)
Frame = +1
Query: 3307 RNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAF 3486
R R + V F+ SR ++ +++ +NTV L +H+ ++F D N++F +F
Sbjct: 447 RKRTRRAVIAFINSRQCFALVIILVFLNTVVLTTEHHNQPEWLDEFQDFANVVFVTLFTM 506
Query: 3487 EAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITY---GKLNPGGTNLISINFFRLFRV 3657
E V+K+ A +YIS +N FD VV+ S +++ + G LNP G +++ R R+
Sbjct: 507 EMVIKMGASXFSDYISKLFNRFDFFVVIFSILELLFVKSGLLNPMGVSVL-----RCARL 561
Query: 3658 MRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSI 3837
+R+ KL E +R+L+ +KS +++ + LL+ + I +++GMQ FG +
Sbjct: 562 LRIFKLTQYWESLRSLVGKLLKSVRSVASLLLLLSIFILICSLLGMQLFGG-RFNFIAHE 620
Query: 3838 HRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNN 4017
NF A+L +F+ TGE W ++M YH E+
Sbjct: 621 KPRANFDGILQAMLTVFQILTGEDWNEVM-----------------YHGMRAYENSPWYG 663
Query: 4018 FAYPYFISFFMLCSFLVINLFVAVIMDNFD 4107
YFI F+ +++++N+F+A+ +DN +
Sbjct: 664 VVVIYFIFLFICGNYILLNVFLAIAVDNLN 693
Score = 102 bits (254), Expect = 1e-19
Identities = 78/306 (25%), Positives = 138/306 (44%), Gaps = 17/306 (5%)
Frame = +1
Query: 247 SIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKI 426
S+V K FE LI I N +AL + Y Q + +L++ Y F VFT+E +L++
Sbjct: 1128 SVVVSKRFEILIFIFIFINTVALML--KYDKQGK-LEARILDSFNYFFTAVFTVEFILRL 1184
Query: 427 VAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKALRAFRVLRPLRL 600
A F Y + N++DF++V+ + I+++ I F V R FRV+R ++L
Sbjct: 1185 SAFSFRH----YFSDIGNVIDFVLVLGSYIDIIVTQSDISQVKFSVNFFRLFRVMRLIKL 1240
Query: 601 VSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLA 780
+S S++ +L ++++ L ++ALL+ + IYA+IG++LF GQ++
Sbjct: 1241 LSKEESIRQLLWTFIKSIQALPYVALLIAMIFFIYAVIGMQLF-------------GQIS 1287
Query: 781 -QKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTV 957
+++P WP + NF NF A+L +
Sbjct: 1288 IEENPL-----------------------------EEEEWPTLHRN-NNFQNFFYALLVL 1317
Query: 958 FQCVSLEGWTDVMYWVND--------------AVGREWPWIYFVTLVILGSFFVLNLVLG 1095
F+C + E W D+M + G + + YF++ + +F V+NL +
Sbjct: 1318 FRCATGESWQDIMMACREGQKCSKDSGETEVNGCGSKLAYAYFISFHAISAFLVINLFVA 1377
Query: 1096 VLSGEF 1113
V+ F
Sbjct: 1378 VIMDNF 1383
Score = 78.6 bits (192), Expect = 2e-12
Identities = 113/555 (20%), Positives = 198/555 (35%), Gaps = 42/555 (7%)
Frame = +1
Query: 1519 MANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKP 1686
M + FF +F++E+ LKM S GF + S FN D VV +++ FVL +
Sbjct: 849 MFDYFFTSVFTVEITLKMISYGFVLHEGAFCRSVFNLLDLIVVCVALVSFVLQNQTIS-- 906
Query: 1687 LGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVF 1866
V +LR R+LR + G+Q+F
Sbjct: 907 -AVKILRVLRVLRPLRAINRAKGLKHVVQCMIIAIKSIGNIVLVTFLLEFMFAVIGVQLF 965
Query: 1867 GGKF----------------------NFNPQQP--------KPRANFDTFVQALLTVFQI 1956
GKF + + + P NFD ALLT+F +
Sbjct: 966 KGKFYSCTDISKHVEEDCKGQFIEYKDMSLEDPILSEREWKNSDFNFDNVPNALLTLFAV 1025
Query: 1957 LTGEDWNTVMYHGIES----FGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLAD 2124
T E W +++Y I+S G + +V +YI I + ++N+F+ +
Sbjct: 1026 STFEGWPSLLYRSIDSNAEDHGPITNYRPVVAFFYITFIILIPFFMINIFVGFVI----- 1080
Query: 2125 ADSLTNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSARPRRMSEVPAAST 2304
ARPRR
Sbjct: 1081 -----------------VTFQKEGEAEYKNCELNKNQRKCIEYALKARPRR--------- 1114
Query: 2305 VKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRN 2484
+ IPK F + ++VV+ + +F + + A++ D +
Sbjct: 1115 -RYIPKGHLQFKI---------WSVVVSKRFEILIFIFIFINTVALMLKYD--KQGKLEA 1162
Query: 2485 MILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDA 2664
IL+ F+YFFT+VFTVE L++ F + + N++D ++V S ++
Sbjct: 1163 RILDSFNYFFTAVFTVEFILRLSAFSF----RHYFSDIGNVIDFVLVLGSYIDIIVTQSD 1218
Query: 2665 MS----XXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAII 2832
+S +++ + ++ ++ I +++ + + L+ M+ F++A+I
Sbjct: 1219 ISQVKFSVNFFRLFRVMRLIKLLSKEESIRQLLWTFIKSIQALPYVALLIAMIFFIYAVI 1278
Query: 2833 GVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMI 3012
G+QLF N L E+ PT + NN NF N A++
Sbjct: 1279 GMQLFGQISIEENPLE--------------EEEWPT-------LHRNN--NFQNFFYALL 1315
Query: 3013 SLFVVSTFEGWPQLL 3057
LF +T E W ++
Sbjct: 1316 VLFRCATGESWQDIM 1330
Score = 77.0 bits (188), Expect = 5e-12
Identities = 49/162 (30%), Positives = 83/162 (50%), Gaps = 7/162 (4%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKH-YPS--SRGFEDFLDVFNLIFTGVFAFEAVLKIVA 3510
V +R FEY I I+ N ++LA H YP S L+ L F +F E+ LKI+A
Sbjct: 74 VDARPFEYFILATILCNCLALAFNHPYPGEDSNAVNQVLEKVELAFVIIFTTESALKIIA 133
Query: 3511 ----LNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLL 3678
L+ Y+ + WNV D +V+ +N I + R FRV+R ++LL
Sbjct: 134 YGFVLHQDAYLRNFWNVLDFSIVLIGLSSKALENMN------IDVKALRAFRVLRPLRLL 187
Query: 3679 SRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF 3804
S ++ +L + + + L ++ALL++ + +YA++G++ F
Sbjct: 188 SGLPSLQVVLNSIITAMVPLLHIALLVIFVIIVYAIVGLELF 229
Score = 74.3 bits (181), Expect = 3e-11
Identities = 65/275 (23%), Positives = 113/275 (40%), Gaps = 26/275 (9%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR--NMILNYF 2502
SL +++ N R C +V+ F +L IL + LA P + N +L
Sbjct: 56 SLCLMTKKNPLRRVCICIVDARPFEYFILATILCNCLALAFNHPYPGEDSNAVNQVLEKV 115
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXX 2682
+ F +FT E LK+I +G V H+ ++ RN +N+LD +V + L+S L +
Sbjct: 116 ELAFVIIFTTESALKIIAYGFVLHQDAYLRNFWNVLDFSIVLIGLSSKALENMNID-VKA 174
Query: 2683 XXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFF 2862
++ L+ V+ +I A+ + +I L+ + ++AI+G++LF+
Sbjct: 175 LRAFRVLRPLRLLSGLPSLQVVLNSIITAMVPLLHIALLVIFVIIVYAIVGLELFQSKLH 234
Query: 2863 LC---NDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDF----------------- 2982
L N K+ E +E T + K D+
Sbjct: 235 LTCYRNSTHKIPEMTPNPRPCTFE----TSSMGFKCSELGPDYFCADMYGKEGERYTGPE 290
Query: 2983 ----NFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
+FDN +M+++FV T EGW Y D+
Sbjct: 291 GGIVSFDNFLYSMLTVFVCITMEGWTSTGYYVSDA 325
Score = 59.7 bits (143), Expect = 8e-07
Identities = 47/216 (21%), Positives = 85/216 (38%), Gaps = 19/216 (8%)
Frame = +1
Query: 1525 NLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMK-PLGVSV 1701
N FF +F++E +L++ + F Y + N D +V+ S ++ ++ D+ + V+
Sbjct: 1169 NYFFTAVFTVEFILRLSAFSFRHYFSDIGNVIDFVLVLGSYIDIIVTQSDISQVKFSVNF 1228
Query: 1702 LRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGG-KF 1878
R R++R+ K+ GMQ+FG
Sbjct: 1229 FRLFRVMRLIKLLSKEESIRQLLWTFIKSIQALPYVALLIAMIFFIYAVIGMQLFGQISI 1288
Query: 1879 NFNPQQPKP------RANFDTFVQALLTVFQILTGEDWNTVMY-----------HGIESF 2007
NP + + NF F ALL +F+ TGE W +M G
Sbjct: 1289 EENPLEEEEWPTLHRNNNFQNFFYALLVLFRCATGESWQDIMMACREGQKCSKDSGETEV 1348
Query: 2008 GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDN 2115
G G+ + Y+I ++++N+F+A+ +DN
Sbjct: 1349 NGCGS--KLAYAYFISFHAISAFLVINLFVAVIMDN 1382
>gi|47228705|emb|CAG07437.1| unnamed protein product [Tetraodon
nigroviridis]
Length = 1618
Score = 867 bits (2239), Expect = 0.0
Identities = 463/877 (52%), Positives = 577/877 (64%), Gaps = 58/877 (6%)
Frame = +1
Query: 2260 SARPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSA 2439
S RPR M+++ P+P+ASS FI N FR C ++N S FTN +L IL+SS
Sbjct: 765 SPRPRPMADLQLKEEAVPLPEASSFFIFGPQNKFRKLCYKIINASSFTNLILLFILLSSI 824
Query: 2440 MLAAEDPLQANSTRNM-------------------------------ILNYFDYFFTSVF 2526
LAAEDP+ S RN IL+Y D FT+VF
Sbjct: 825 SLAAEDPIDPKSYRNQVTKQNQIFLCVGNSSSWRKTNTDASFLLLLQILSYADIVFTTVF 884
Query: 2527 TVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXXXXXXXXXX 2706
T+EI LK+ V+G HKGSFCRN+FN+LD++VV VSL S + + A+S
Sbjct: 885 TIEIVLKMTVYGAFMHKGSFCRNSFNILDLIVVGVSLLSMGMESSAISVVKILRVLRVLR 944
Query: 2707 XXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKM 2886
AINRAKGLKHVVQCV VA+KTIGNI+LVT +L FMFA IGVQLFKG F+ C D SK+
Sbjct: 945 PLRAINRAKGLKHVVQCVFVAIKTIGNIVLVTMLLNFMFACIGVQLFKGKFYSCTDSSKL 1004
Query: 2887 TEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVA 3066
TE EC+G ++ + + V KR W N+DFNFDNV M++LF VST EGWP+LLY A
Sbjct: 1005 TEEECQGFFLKHMENSLQDTVLAKREWLNSDFNFDNVLYGMLALFTVSTIEGWPELLYRA 1064
Query: 3067 IDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIVTFQNEGEREYENCELDK 3246
IDS++ED GP+ N+R V++ GFVIVTFQ +GE+EY++CELDK
Sbjct: 1065 IDSDKEDMGPVFNNRVDVSIFFIIYIILIAFFMMNIFVGFVIVTFQEQGEQEYKDCELDK 1124
Query: 3247 NQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSS 3426
NQR+C+++ALKA+P R YIP+N QYR H S
Sbjct: 1125 NQRQCVQYALKARPLRCYIPKNPYQYR----------------------------HCNQS 1156
Query: 3427 RGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLN 3606
D NLIFT +F E +LK++A K Y D WNVFD ++V+GS +D+ +++
Sbjct: 1157 DHVTKLSDTLNLIFTVLFTVEMILKLMAFKIKGYFGDPWNVFDFIIVIGSVVDVILSEVD 1216
Query: 3607 P-----GG---------TN-----------LISINFFRLFRVMRLVKLLSRGEGIRTLLW 3711
GG TN +SI FFRLFRVMRLVKLL+R EGIR LLW
Sbjct: 1217 TALASSGGLYCLHGCADTNPMQAIADSENASVSITFFRLFRVMRLVKLLNRSEGIRNLLW 1276
Query: 3712 TFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFR 3891
TF+KSFQALP+VALLIV+LFFIYAVIGMQ FGKVAL D T IHRNNNF +FP A+L+LFR
Sbjct: 1277 TFIKSFQALPHVALLIVMLFFIYAVIGMQIFGKVALVDGTQIHRNNNFQTFPQAVLMLFR 1336
Query: 3892 SATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVI 4071
ATGE WQ++M++ + +CDP S+ E CG+NFA YF+SF+ LC+FL++
Sbjct: 1337 CATGEDWQEVMMASMYGK--KCDPKSEVLPG---EEYTCGSNFAVIYFLSFYCLCAFLIL 1391
Query: 4072 NLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPL 4251
NLFVAVIMDNFDYLTRDWS+LGPHHL+EF ++W+EYDP+A GRIKHLDVVTLLR+I PPL
Sbjct: 1392 NLFVAVIMDNFDYLTRDWSLLGPHHLDEFKKIWAEYDPEATGRIKHLDVVTLLRRIQPPL 1451
Query: 4252 GFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNIDEANEQLRSA 4431
GFGK CPHR ACKRLV MNMPLNSDGTV FNATLFALVRT LKI TEGN ++ANE+LR+
Sbjct: 1452 GFGKFCPHRAACKRLVGMNMPLNSDGTVTFNATLFALVRTALKIKTEGNFEKANEELRAI 1511
Query: 4432 IKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEMEAKGVLPA-Q 4608
IK+IWKRT LLD+V+PP G +D+VTVGKFYATFL+QD+FR+F K +E E G P +
Sbjct: 1512 IKQIWKRTSMKLLDQVIPPLG-DDEVTVGKFYATFLLQDHFRKFLKCQE-EYYGYRPTKK 1569
Query: 4609 TPQAMALQAGLRTL-HEIGPELKRAISGNLETDFNFD 4716
+ +QAGLR + E+ PE+ R ISG+L+ + D
Sbjct: 1570 SASGPEIQAGLRAIDEELAPEMHRTISGDLQNEEEMD 1606
Score = 638 bits (1645), Expect = 0.0
Identities = 334/653 (51%), Positives = 422/653 (64%), Gaps = 12/653 (1%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP RK CI+IVEWK FE +IL I ANC+ALA++ P P +DS+ N LE++EY+F+V+F
Sbjct: 49 NPFRKACINIVEWKAFEIIILLTIFANCVALAVFLPMPEEDSNNTNASLESLEYIFLVIF 108
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSI---------QGFD 555
T+EC LKIVA GF+FH AYLRN WNILDF+IV +GL + L ++ GFD
Sbjct: 109 TLECFLKIVAYGFVFHEGAYLRNCWNILDFVIVFMGLFTFALDTINKIAGVPLEKGGGFD 168
Query: 556 VKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCG 735
+KALRAFRVLRPLRLVSGVPSLQVV+N+IL+AM+PLLHIALLV ++ IYAI+GLELF
Sbjct: 169 MKALRAFRVLRPLRLVSGVPSLQVVMNSILKAMLPLLHIALLVFLLVTIYAIMGLELFKC 228
Query: 736 KLHSTCIDPATGQLAQKD---PTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGP 906
K+H TC T + + P PC G+ +C + S EC W GP
Sbjct: 229 KMHKTCYYTGTNIYSTAEGELPAPCAQ--AGNGRRCTINSS--------ECRPG--WEGP 276
Query: 907 NNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNL 1086
NNGIT+FDN G AMLTV+QC+++EGWT V+YWVNDA+G EWPW+YFV L++LGSFFVLNL
Sbjct: 277 NNGITHFDNIGFAMLTVYQCITMEGWTKVLYWVNDAIGNEWPWLYFVPLILLGSFFVLNL 336
Query: 1087 VLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEP 1266
VLGVLSGEF+KEREKAR+RG FQK RE+QQL+EDL GY++WIT AE ++ E +
Sbjct: 337 VLGVLSGEFTKEREKARSRGEFQKLRERQQLDEDLHGYMEWITHAEVLDADREGK----- 391
Query: 1267 VAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXX 1446
SK + + N VK+++FYW
Sbjct: 392 --GLLPLTGGDSETDSLYGLEGKSKIIYYYRLARRWNRFFRMKCLVYVKTKSFYWLVMFL 449
Query: 1447 XXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDC 1626
+E++ Q +WL Q MA+ ++LF +EM +KMY+LG Y S FNRFD
Sbjct: 450 VFLNTLTIATEYHHQPQWLTSLQDMASRVLLVLFIVEMFIKMYALGLRAYFMSLFNRFDF 509
Query: 1627 FVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXX 1806
FVV+ ILE +L + PLG SVLR RLLRI KVTKYWT
Sbjct: 510 FVVLCGILEMILFSAGAVTPLGFSVLRCIRLLRILKVTKYWTSLSNLVASLLNSVRSIAS 569
Query: 1807 XXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVM 1986
GMQVFGGKFNF+ +P+ R+NFD F QAL++VFQILTGE+W +M
Sbjct: 570 LLLLLFLFIVIFSLLGMQVFGGKFNFSDHRPR-RSNFDNFPQALISVFQILTGEEWTNIM 628
Query: 1987 YHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNA 2145
Y+GI ++GG G++V IY+IVLF+CGNYILLNVFLAIAVDNLA+A+SLT+A
Sbjct: 629 YNGIMAYGGPVFPGILVAIYFIVLFVCGNYILLNVFLAIAVDNLAEAESLTSA 681
Score = 154 bits (390), Expect = 2e-35
Identities = 144/666 (21%), Positives = 279/666 (41%), Gaps = 73/666 (10%)
Frame = +1
Query: 2323 ASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPL--QANSTRNMILN 2496
A SLF + N FR C +V F +L I + LA P+ + ++ N L
Sbjct: 39 ARSLFFFTLKNPFRKACINIVEWKAFEIIILLTIFANCVALAVFLPMPEEDSNNTNASLE 98
Query: 2497 YFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRT------ 2658
+Y F +FT+E LK++ +G VFH+G++ RN +N+LD ++V + L +F L T
Sbjct: 99 SLEYIFLVIFTLECFLKIVAYGFVFHEGAYLRNCWNILDFVIVFMGLFTFALDTINKIAG 158
Query: 2659 -----DAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
++ L+ V+ ++ A+ + +I L+ F+L ++
Sbjct: 159 VPLEKGGGFDMKALRAFRVLRPLRLVSGVPSLQVVMNSILKAMLPLLHIALLVFLLVTIY 218
Query: 2824 AIIGVQLFK-----GTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSK--KRVW---SN 2973
AI+G++LFK ++ ++ E E +G S + W +N
Sbjct: 219 AIMGLELFKCKMHKTCYYTGTNIYSTAEGELPAPCAQAGNGRRCTINSSECRPGWEGPNN 278
Query: 2974 NDFNFDNVGDAMISLFVVSTFEG---------------WPQLLYVAID------------ 3072
+FDN+G AM++++ T EG WP L +V +
Sbjct: 279 GITHFDNIGFAMLTVYQCITMEGWTKVLYWVNDAIGNEWPWLYFVPLILLGSFFVLNLVL 338
Query: 3073 -------SNEEDK----GPIHNSRQAVALXXXXX------XXXXXXXXXXXXXGFVIVTF 3201
+ E +K G R+ L G + +T
Sbjct: 339 GVLSGEFTKEREKARSRGEFQKLRERQQLDEDLHGYMEWITHAEVLDADREGKGLLPLT- 397
Query: 3202 QNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVTSRAFEYVIFLII 3381
G+ E ++ + + K I + A+ R+ L Y V +++F +++ ++
Sbjct: 398 --GGDSETDSLYGLEGKSKIIYYYRLARRWNRFFRMKCLVY-----VKTKSFYWLVMFLV 450
Query: 3382 VMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLL 3561
+NT+++A +++ + D+ + + +F E +K+ AL + Y +N FD
Sbjct: 451 FLNTLTIATEYHHQPQWLTSLQDMASRVLLVLFIVEMFIKMYALGLRAYFMSLFNRFDFF 510
Query: 3562 VVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALP 3741
VV+ +++ + G + + R R++R++K+ + L+ + + S +++
Sbjct: 511 VVLCGILEMIL--FSAGAVTPLGFSVLRCIRLLRILKVTKYWTSLSNLVASLLNSVRSIA 568
Query: 3742 YVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDI 3921
+ LL+ L I++++GMQ FG + S R +NF +FP A++ +F+ TGE W +I
Sbjct: 569 SLLLLLFLFIVIFSLLGMQVFGG-KFNFSDHRPRRSNFDNFPQALISVFQILTGEEWTNI 627
Query: 3922 MLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP------YFISFFMLCSFLVINLFV 4083
M N +P YFI F+ +++++N+F+
Sbjct: 628 M----------------------YNGIMAYGGPVFPGILVAIYFIVLFVCGNYILLNVFL 665
Query: 4084 AVIMDN 4101
A+ +DN
Sbjct: 666 AIAVDN 671
Score = 119 bits (297), Expect = 1e-24
Identities = 102/370 (27%), Positives = 167/370 (44%), Gaps = 38/370 (10%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V N RKLC I+ F LIL I + I+L
Sbjct: 767 RPRPMADLQLKEEAVPLPEASSFFIFGPQNKFRKLCYKIINASSFTNLILLFILLSSISL 826
Query: 316 AIYQPYPAQD------------------SDYKNT--------LLETIEY---VFIVVFTI 408
A P + S ++ T LL+ + Y VF VFTI
Sbjct: 827 AAEDPIDPKSYRNQVTKQNQIFLCVGNSSSWRKTNTDASFLLLLQILSYADIVFTTVFTI 886
Query: 409 ECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLR 588
E VLK+ G H ++ RN++NILD I+V + L+S + +I VK LR RVLR
Sbjct: 887 EIVLKMTVYGAFMHKGSFCRNSFNILDLIVVGVSLLSMGMESSAIS--VVKILRVLRVLR 944
Query: 589 PLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPAT 768
PLR ++ L+ V+ + A+ + +I L+ + + ++A IG++LF GK +S C D +
Sbjct: 945 PLRAINRAKGLKHVVQCVFVAIKTIGNIVLVTMLLNFMFACIGVQLFKGKFYS-CTD--S 1001
Query: 769 GQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAM 948
+L ++ + +G K + + + E W N NFDN M
Sbjct: 1002 SKLTEE-------ECQGFFLKHMENSLQDTVLAKRE------W---LNSDFNFDNVLYGM 1045
Query: 949 LTVFQCVSLEGWTDVMYWVNDA---------VGREWPWIYFVTLVILGSFFVLNLVLGVL 1101
L +F ++EGW +++Y D+ R I+F+ +IL +FF++N+ +G +
Sbjct: 1046 LALFTVSTIEGWPELLYRAIDSDKEDMGPVFNNRVDVSIFFIIYIILIAFFMMNIFVGFV 1105
Query: 1102 SGEFSKEREK 1131
F ++ E+
Sbjct: 1106 IVTFQEQGEQ 1115
Score = 83.6 bits (205), Expect = 5e-14
Identities = 71/308 (23%), Positives = 121/308 (39%), Gaps = 44/308 (14%)
Frame = +1
Query: 322 YQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIV 501
YQ SD+ L +T+ +F V+FT+E +LK++A F Y + WN+ DFIIV
Sbjct: 1148 YQYRHCNQSDHVTKLSDTLNLIFTVLFTVEMILKLMA----FKIKGYFGDPWNVFDFIIV 1203
Query: 502 VIGLVSTILSKMSIQ----------------------------GFDVKALRAFRVLRPLR 597
+ +V ILS++ + R FRV+R ++
Sbjct: 1204 IGSVVDVILSEVDTALASSGGLYCLHGCADTNPMQAIADSENASVSITFFRLFRVMRLVK 1263
Query: 598 LVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQL 777
L++ ++ +L +++ L H+ALL++ + IYA+IG+++F G++
Sbjct: 1264 LLNRSEGIRNLLWTFIKSFQALPHVALLIVMLFFIYAVIGMQIF-------------GKV 1310
Query: 778 AQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTV 957
A D T + NF F A+L +
Sbjct: 1311 ALVDGTQIHRN------------------------------------NNFQTFPQAVLML 1334
Query: 958 FQCVSLEGWTDVMY----------------WVNDAVGREWPWIYFVTLVILGSFFVLNLV 1089
F+C + E W +VM G + IYF++ L +F +LNL
Sbjct: 1335 FRCATGEDWQEVMMASMYGKKCDPKSEVLPGEEYTCGSNFAVIYFLSFYCLCAFLILNLF 1394
Query: 1090 LGVLSGEF 1113
+ V+ F
Sbjct: 1395 VAVIMDNF 1402
Score = 82.8 bits (203), Expect = 9e-14
Identities = 84/340 (24%), Positives = 143/340 (41%), Gaps = 17/340 (5%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
N R C+ V+ K F +L++F++ N + +A + Q + +L + V +V+
Sbjct: 426 NRFFRMKCLVYVKTKSFYWLVMFLVFLNTLTIATEYHHQPQ---WLTSLQDMASRVLLVL 482
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTIL-SKMSIQGFDVKALRAF 576
F +E +K+ A+G AY + +N DF +V+ G++ IL S ++ LR
Sbjct: 483 FIVEMFIKMYALGLR----AYFMSLFNRFDFFVVLCGILEMILFSAGAVTPLGFSVLRCI 538
Query: 577 RVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI 756
R+LR L++ SL ++ ++L ++ IA L+L + L I L
Sbjct: 539 RLLRILKVTKYWTSLSNLVASLLNSV---RSIASLLLLLFLFIVIFSL------------ 583
Query: 757 DPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNF 936
G G F N + P +NFDNF
Sbjct: 584 --------------LGMQVFGGKF-------------------NFSDHRPRR--SNFDNF 608
Query: 937 GLAMLTVFQCVSLEGWTDVMY-WVNDAVGREWPW----IYFVTLVILGSFFVLNLVLGV- 1098
A+++VFQ ++ E WT++MY + G +P IYF+ L + G++ +LN+ L +
Sbjct: 609 PQALISVFQILTGEEWTNIMYNGIMAYGGPVFPGILVAIYFIVLFVCGNYILLNVFLAIA 668
Query: 1099 ----------LSGEFSKEREKARARGLFQKFREKQQLEED 1188
S + K EK R + L K EK E +
Sbjct: 669 VDNLAEAESLTSAQKEKAEEKLRRKLLRSKMPEKTDEERE 708
Score = 70.5 bits (171), Expect = 5e-10
Identities = 58/250 (23%), Positives = 94/250 (37%), Gaps = 38/250 (15%)
Frame = +1
Query: 1480 HYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFV 1659
H QS+ + NL F +LF++EM+LK+ + Y +N FD +VI S+++ +
Sbjct: 1152 HCNQSDHVTKLSDTLNLIFTVLFTVEMILKLMAFKIKGYFGDPWNVFDFIIVIGSVVDVI 1211
Query: 1660 LVYFDLM---------------------------KPLGVSVLRSARLLRIFKVTKYWTXX 1758
L D + ++ R R++R+ K+
Sbjct: 1212 LSEVDTALASSGGLYCLHGCADTNPMQAIADSENASVSITFFRLFRVMRLVKLLNRSEGI 1271
Query: 1759 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQAL 1938
GMQ+FG + Q NF TF QA+
Sbjct: 1272 RNLLWTFIKSFQALPHVALLIVMLFFIYAVIGMQIFGKVALVDGTQIHRNNNFQTFPQAV 1331
Query: 1939 LTVFQILTGEDWNTVMYHGIESF----------GGVGTLGVIVCIYYIVLFIC-GNYILL 2085
L +F+ TGEDW VM + G T G + Y + F C +++L
Sbjct: 1332 LMLFRCATGEDWQEVMMASMYGKKCDPKSEVLPGEEYTCGSNFAVIYFLSFYCLCAFLIL 1391
Query: 2086 NVFLAIAVDN 2115
N+F+A+ +DN
Sbjct: 1392 NLFVAVIMDN 1401
Score = 40.0 bits (92), Expect = 0.65
Identities = 48/234 (20%), Positives = 82/234 (34%), Gaps = 38/234 (16%)
Frame = +1
Query: 1522 ANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPL 1689
A++ F +F++E++LKM G ++ + FN D VV S+L + +
Sbjct: 876 ADIVFTTVFTIEIVLKMTVYGAFMHKGSFCRNSFNILDLIVVGVSLLSMGMESSAISV-- 933
Query: 1690 GVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFG 1869
V +LR R+LR + G+Q+F
Sbjct: 934 -VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIKTIGNIVLVTMLLNFMFACIGVQLFK 992
Query: 1870 GKFNFNPQQPKPRA------------------------------NFDTFVQALLTVFQIL 1959
GKF K NFD + +L +F +
Sbjct: 993 GKFYSCTDSSKLTEEECQGFFLKHMENSLQDTVLAKREWLNSDFNFDNVLYGMLALFTVS 1052
Query: 1960 TGEDWNTVMYHGIES----FGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
T E W ++Y I+S G V V V I++I+ I + ++N+F+ +
Sbjct: 1053 TIEGWPELLYRAIDSDKEDMGPVFNNRVDVSIFFIIYIILIAFFMMNIFVGFVI 1106
>gi|38073276|ref|XP_358335.1| calcium channel, voltage-dependent, L
type, alpha 1S subunit [Mus musculus]
Length = 1444
Score = 852 bits (2202), Expect = 0.0
Identities = 422/677 (62%), Positives = 511/677 (75%), Gaps = 1/677 (0%)
Frame = +1
Query: 2260 SARPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSA 2439
S RPR ++E+ PIP+ASS FI S TN RV C+ +VN ++FTN +L IL+SSA
Sbjct: 755 SPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSA 814
Query: 2440 MLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDIL 2619
LAAEDP++A+S RN IL YFDY FT+VFTVEI LK+ +G HKGSFCRN FN+LD+L
Sbjct: 815 ALAAEDPIRADSMRNQILEYFDYVFTAVFTVEIVLKMTTYGAFLHKGSFCRNYFNILDLL 874
Query: 2620 VVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLV 2799
VVAVSL S L + A+S AINRAKGLKHVVQCV VA++TIGNI+LV
Sbjct: 875 VVAVSLISMGLESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVLV 934
Query: 2800 TFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNND 2979
T +LQFMFA IGVQLFKG F+ CNDLSKMTE ECRG Y Y+DGDPT+ + R W +ND
Sbjct: 935 TTLLQFMFACIGVQLFKGKFYSCNDLSKMTEEECRGYYYIYKDGDPTQIELRPRQWIHND 994
Query: 2980 FNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXX 3159
F+FDNV AM+SLF VSTFEGWPQLLY AIDSNEED GP++N+R +A+
Sbjct: 995 FHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNEEDTGPVYNNRVEMAIFFIIYIILIAF 1054
Query: 3160 XXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWF 3339
GFVIVTFQ +GE EY+NCELDKNQR+C+++ALKA+P R YIP+N QY+VW+
Sbjct: 1055 FMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQVWYV 1114
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
VTS FEY++F +I++NT+ L +HY S D+ N+ FT +F E VLK++A P
Sbjct: 1115 VTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMVLKLIAFKP 1174
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKL-NPGGTNLISINFFRLFRVMRLVKLLSRGEGI 3696
+ Y D WNVFD L+V+GS ID+ ++ +P + IS FFRLFRVMRLVKLL+R EG+
Sbjct: 1175 RGYFGDPWNVFDFLIVIGSIIDVILSEIDDPDESARISSAFFRLFRVMRLVKLLNRAEGV 1234
Query: 3697 RTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAI 3876
RTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+A+ D T I+RNNNF +FP A+
Sbjct: 1235 RTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIAMVDGTQINRNNNFQTFPQAV 1294
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLC 4056
L+LFR ATGEAWQ+I+L+CS + CDP S DY G E CG NFAY YFISF+MLC
Sbjct: 1295 LLLFRCATGEAWQEILLACSYGK--LCDPES-DYAPG--EEHTCGTNFAYYYFISFYMLC 1349
Query: 4057 SFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRK 4236
+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF +W+EYDP+AKGRIKHLDVVTLLR+
Sbjct: 1350 AFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRR 1409
Query: 4237 ISPPLGFGKLCPHRLAC 4287
I PPLGFGK CPHR+AC
Sbjct: 1410 IQPPLGFGKFCPHRVAC 1426
Score = 676 bits (1743), Expect = 0.0
Identities = 352/659 (53%), Positives = 441/659 (66%), Gaps = 18/659 (2%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+RK CISIVEWKPFE +IL I ANC+ALA+Y P P D++ N LE +EY F++VF
Sbjct: 38 NPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNTLNLGLEKLEYFFLIVF 97
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSI------------Q 546
+IE +KI+A GF+FH AYLR+ WN+LDFIIV +G+ + IL +++I
Sbjct: 98 SIEAAMKIIAYGFLFHQDAYLRSGWNVLDFIIVFLGVFTVILEQVNIIQTNTAPMSSKGA 157
Query: 547 GFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLEL 726
G DVKALRAFRVLRPLRLVSGVPSLQVVLN+I +AM+PL HIALLVLF+++IYAIIGLEL
Sbjct: 158 GLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLEL 217
Query: 727 FCGKLHSTCIDPATGQLA---QKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTW 897
F GK+H TC T +A + P+PC GS C + S EC W
Sbjct: 218 FKGKMHKTCYFIGTDIVATVENEKPSPCART--GSGRPCTINGS--------ECRGG--W 265
Query: 898 PGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFV 1077
PGPN+GIT+FDNFG +MLTV+QC+S+EGWTDV+YWVNDA+G EWPWIYFVTL++LGSFF+
Sbjct: 266 PGPNHGITHFDNFGFSMLTVYQCISMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFI 325
Query: 1078 LNLVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAE--DIEPVNEDE 1251
LNLVLGVLSGEF+KEREKA++RG FQK REKQQLEEDL+GY+ WITQ E D++ + E +
Sbjct: 326 LNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLEEDLRGYMSWITQGEVMDVDDLREGK 385
Query: 1252 QE-DEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFY 1428
DE + T +K ++ + N LVKS+ FY
Sbjct: 386 LSLDEGGSDTESLYEIEGL----------NKIIQFIRHWRQWNRVFRWKCHDLVKSKVFY 435
Query: 1429 WXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQ 1608
W SEH+ Q WL H Q +AN + LF++EML+KMY LG Y S
Sbjct: 436 WLVILIVALNTLSIASEHHNQPLWLTHLQDVANRVLLTLFTIEMLMKMYGLGLRQYFMSI 495
Query: 1609 FNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXX 1788
FNRFDCFVV S ILE +LV M PLG+SVLR RLLR+FK+TKYWT
Sbjct: 496 FNRFDCFVVCSGILEILLVESGAMSPLGISVLRCIRLLRLFKITKYWTSLSNLVASLLNS 555
Query: 1789 XXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGE 1968
GMQ+FGG+++F + + R+NFD F QAL++VFQ+LTGE
Sbjct: 556 IRSIASLLLLLFLFIIIFALLGMQLFGGRYDFEDTEVR-RSNFDNFPQALISVFQVLTGE 614
Query: 1969 DWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNA 2145
DWN+VMY+GI ++GG GV+VCIY+I+LF+CGNYILLNVFLAIAVDNLA+A+SLT+A
Sbjct: 615 DWNSVMYNGIMAYGGPTYPGVLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTSA 673
Score = 168 bits (426), Expect = 1e-39
Identities = 154/671 (22%), Positives = 282/671 (41%), Gaps = 73/671 (10%)
Frame = +1
Query: 2308 KPIPKA-----SSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQA- 2469
KP+P+ +LF L+ N R C +V F +L I + LA P+
Sbjct: 18 KPVPEILPRPPRALFCLTLQNPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPED 77
Query: 2470 -NSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSF 2646
N+T N+ L +YFF VF++E +K+I +G +FH+ ++ R+ +N+LD ++V + + +
Sbjct: 78 DNNTLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFIIVFLGVFTV 137
Query: 2647 VLR--------TDAMSXXXXXXXXXXXXXXXAINRAK------GLKHVVQCVIVAVKTIG 2784
+L T MS + + L+ V+ + A+ +
Sbjct: 138 ILEQVNIIQTNTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLF 197
Query: 2785 NIMLVTFMLQFMFAIIGVQLFKGT-----FFLCNDLSKMTEAECRGEYIHYEDGDP-TKP 2946
+I L+ + ++AIIG++LFKG +F+ D+ E E G P T
Sbjct: 198 HIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEKPSPCARTGSGRPCTIN 257
Query: 2947 VSKKRV-WSNNDF---NFDNVGDAMISLFVVSTFEG---------------WPQLLYVAI 3069
S+ R W + +FDN G +M++++ + EG WP + +V +
Sbjct: 258 GSECRGGWPGPNHGITHFDNFGFSMLTVYQCISMEGWTDVLYWVNDAIGNEWPWIYFVTL 317
Query: 3070 D-------------------SNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVI 3192
+ E +K + Q + +
Sbjct: 318 ILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLEEDLRGYMSWITQGEVMD 377
Query: 3193 VTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPR-NRL-QYRVWWFVTSRAFEYV 3366
V EG+ + D IE K R+ + NR+ +++ V S+ F ++
Sbjct: 378 VDDLREGKLSLDEGGSDTESLYEIEGLNKIIQFIRHWRQWNRVFRWKCHDLVKSKVFYWL 437
Query: 3367 IFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWN 3546
+ LI+ +NT+S+A +H+ DV N + +F E ++K+ L + Y +N
Sbjct: 438 VILIVALNTLSIASEHHNQPLWLTHLQDVANRVLLTLFTIEMLMKMYGLGLRQYFMSIFN 497
Query: 3547 VFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKS 3726
FD VV ++I + G + + I+ R R++RL K+ + L+ + + S
Sbjct: 498 RFDCFVVCSGILEILL--VESGAMSPLGISVLRCIRLLRLFKITKYWTSLSNLVASLLNS 555
Query: 3727 FQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGE 3906
+++ + LL+ L I+A++GMQ FG + T + R +NF +FP A++ +F+ TGE
Sbjct: 556 IRSIASLLLLLFLFIIIFALLGMQLFGGRYDFEDTEV-RRSNFDNFPQALISVFQVLTGE 614
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP------YFISFFMLCSFLV 4068
W +M N YP YFI F+ ++++
Sbjct: 615 DWNSVM----------------------YNGIMAYGGPTYPGVLVCIYFIILFVCGNYIL 652
Query: 4069 INLFVAVIMDN 4101
+N+F+A+ +DN
Sbjct: 653 LNVFLAIAVDN 663
Score = 127 bits (318), Expect = 4e-27
Identities = 103/343 (30%), Positives = 159/343 (46%), Gaps = 12/343 (3%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V N IR LC IV F IL I + AL
Sbjct: 757 RPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAAL 816
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P A +N +LE +YVF VFT+E VLK+ G H ++ RN +NILD +
Sbjct: 817 AAEDPIRADSM--RNQILEYFDYVFTAVFTVEIVLKMTTYGAFLHKGSFCRNYFNILDLL 874
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S L +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 875 VVAVSLISMGLESSAIS--VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIV 932
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLT 855
L+ + ++A IG++LF GK +S C D L++ C G + + D T
Sbjct: 933 LVTTLLQFMFACIGVQLFKGKFYS-CND-----LSKMTEEEC----RGYYYIYKDGDP-T 981
Query: 856 NMGVRWECSSNTTWPGPNNGITN---FDNFGLAMLTVFQCVSLEGWTDVMYWVNDA---- 1014
+ +R P I N FDN AM+++F + EGW ++Y D+
Sbjct: 982 QIELR-----------PRQWIHNDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNEED 1030
Query: 1015 -----VGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKERE 1128
R I+F+ +IL +FF++N+ +G + F ++ E
Sbjct: 1031 TGPVYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGE 1073
Score = 99.8 bits (247), Expect = 7e-19
Identities = 74/317 (23%), Positives = 138/317 (43%), Gaps = 20/317 (6%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP + +V FE+L+ +I N I L + Q Y S+ N + + + F ++F
Sbjct: 1105 NPYQYQVWYVVTSSYFEYLMFALIMLNTICLGM-QHY--NQSEQMNHISDILNVAFTIIF 1161
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKA----LR 570
T+E VLK++A F P Y + WN+ DF+IV+ ++ ILS++ + R
Sbjct: 1162 TLEMVLKLIA----FKPRGYFGDPWNVFDFLIVIGSIIDVILSEIDDPDESARISSAFFR 1217
Query: 571 AFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHST 750
FRV+R ++L++ ++ +L +++ L ++ALL++ + IYA+IG+++F
Sbjct: 1218 LFRVMRLVKLLNRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMF------- 1270
Query: 751 CIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFD 930
G++A D T N NF
Sbjct: 1271 ------GKIAMVDGTQI------------------------------------NRNNNFQ 1288
Query: 931 NFGLAMLTVFQCVSLEGWTDVMYWVN----------------DAVGREWPWIYFVTLVIL 1062
F A+L +F+C + E W +++ + G + + YF++ +L
Sbjct: 1289 TFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGEEHTCGTNFAYYYFISFYML 1348
Query: 1063 GSFFVLNLVLGVLSGEF 1113
+F ++NL + V+ F
Sbjct: 1349 CAFLIINLFVAVIMDNF 1365
Score = 80.5 bits (197), Expect = 4e-13
Identities = 58/228 (25%), Positives = 98/228 (42%), Gaps = 15/228 (6%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HY QSE ++H + N+ F I+F++EM+LK+ + Y +N FD +VI SI++
Sbjct: 1138 QHYNQSEQMNHISDILNVAFTIIFTLEMVLKLIAFKPRGYFGDPWNVFDFLIVIGSIIDV 1197
Query: 1657 VLVYFD---LMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXX 1827
+L D + + R R++R+ K+
Sbjct: 1198 ILSEIDDPDESARISSAFFRLFRVMRLVKLLNRAEGVRTLLWTFIKSFQALPYVALLIVM 1257
Query: 1828 XXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMY------ 1989
GMQ+FG + Q NF TF QA+L +F+ TGE W ++
Sbjct: 1258 LFFIYAVIGMQMFGKIAMVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGK 1317
Query: 1990 ----HGIESFGGVGTLGVIVCIYYIVLF--ICGNYILLNVFLAIAVDN 2115
+ G T G YY + F +C ++++N+F+A+ +DN
Sbjct: 1318 LCDPESDYAPGEEHTCGTNFAYYYFISFYMLCA-FLIINLFVAVIMDN 1364
Score = 40.8 bits (94), Expect = 0.38
Identities = 47/230 (20%), Positives = 87/230 (37%), Gaps = 38/230 (16%)
Frame = +1
Query: 1534 FVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSV 1701
F +F++E++LKM + G ++ + FN D VV S++ L + V +
Sbjct: 839 FTAVFTVEIVLKMTTYGAFLHKGSFCRNYFNILDLLVVAVSLISMGLESSAISV---VKI 895
Query: 1702 LRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF- 1878
LR R+LR + G+Q+F GKF
Sbjct: 896 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVLVTTLLQFMFACIGVQLFKGKFY 955
Query: 1879 ---------------------NFNPQQPKPRA--------NFDTFVQALLTVFQILTGED 1971
+ +P Q + R +FD + A++++F + T E
Sbjct: 956 SCNDLSKMTEEECRGYYYIYKDGDPTQIELRPRQWIHNDFHFDNVLSAMMSLFTVSTFEG 1015
Query: 1972 WNTVMYHGIES----FGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
W ++Y I+S G V V + I++I+ I + ++N+F+ +
Sbjct: 1016 WPQLLYKAIDSNEEDTGPVYNNRVEMAIFFIIYIILIAFFMMNIFVGFVI 1065
>gi|48095459|ref|XP_392298.1| similar to ENSANGP00000023154 [Apis
mellifera]
Length = 1952
Score = 822 bits (2123), Expect = 0.0
Identities = 487/1212 (40%), Positives = 643/1212 (52%), Gaps = 86/1212 (7%)
Frame = +1
Query: 763 ATGQLAQKDPTPCGTDTEGSA-FKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFG 939
A+G + +PC TD + A F D+ + C + W GPN GIT+FDN G
Sbjct: 298 ASGISEGEQASPCNTDNKSEAPFGAHVCDANIST-----CMDH--WEGPNFGITSFDNIG 350
Query: 940 LAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSK 1119
AMLTVFQC+++EGWT ++YW NDA+G + WIYF+ L++LGSFF+LNLVLGVLSGEF+K
Sbjct: 351 FAMLTVFQCITMEGWTAILYWTNDALGSTYNWIYFIPLIVLGSFFMLNLVLGVLSGEFAK 410
Query: 1120 EREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPV---------- 1269
EREK R F K R +QQLE +L YL+WI +AE++ E E+E
Sbjct: 411 EREKVENRQSFLKLRRQQQLEHELYCYLNWICKAEEVILAEERTTEEEKKHILEGRKRAE 470
Query: 1270 ----------AQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQ 1419
+ +K K+ VKSQ
Sbjct: 471 AKKKKLGKSKSTDTEEEEGDDDQDDGFSRSSSTKEKGPCKQFWLAEKRFRYWIRKSVKSQ 530
Query: 1420 TFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYT 1599
FYW EHYGQ +WL F A F+ LF +EM +K+Y+LG TY
Sbjct: 531 KFYWFVIVLVFFNTVCVAVEHYGQPQWLTDFLYFAEFVFLALFMLEMFIKVYALGPRTYF 590
Query: 1600 TSQFNRFDCFVVISSILEFVLVYFDLMK-PLGVSVLRSARLLRIFKVTKYWTXXXXXXXX 1776
S FNRFDC V+ SI E +++ ++ G+SVLR+ RLLRIFKVTKYW
Sbjct: 591 DSSFNRFDCVVISGSIFE--VIWSEVKSGSFGLSVLRALRLLRIFKVTKYWKSLRNLVIS 648
Query: 1777 XXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQI 1956
GMQ+FGG+FNF+ P NF+TF ALLTVFQI
Sbjct: 649 LLSSMRSIISLLFLLFLFILIFALLGMQLFGGQFNFDSGTPP--TNFNTFPIALLTVFQI 706
Query: 1957 LTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSL 2136
LTGEDWN VMY GIES GG G+I +Y+IVL + GNY LLNVFLAIAVDNL D
Sbjct: 707 LTGEDWNEVMYQGIESQGG-HKKGMIYSLYFIVLVLFGNYTLLNVFLAIAVDNLNPKDG- 764
Query: 2137 TNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSARPRRMSEVPAASTVKPI 2316
S+ + + + KP+
Sbjct: 765 -----------------GAPKVEICPPSPNQNFKDGKGGKQSSEEEKKQDEDDDTGPKPM 807
Query: 2317 PKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMILN 2496
SS+FILS TN R + VVN YF ++ I +SS LAAEDP+ +S RN +LN
Sbjct: 808 LPYSSMFILSPTNPVRRAAHWVVNLRYFDFFIMVVISLSSIALAAEDPVWEDSPRNEVLN 867
Query: 2497 YFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDA---- 2664
YFDY FT VFTVE+ LK+I G++ H GS+ R +N++D +VV + SF
Sbjct: 868 YFDYAFTGVFTVEMILKIIDLGIILHPGSYLREFWNIMDAVVVICAAVSFAFDMTGSSAG 927
Query: 2665 --MSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGV 2838
+S I R LK V CV+ ++K + NI++V + QF+FA+I V
Sbjct: 928 QNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVINILIVYILFQFIFAVIAV 987
Query: 2839 QLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISL 3018
QLF G FF C+D SK T+ +C+G+Y +EDG P KKR W + F++DNV AM++L
Sbjct: 988 QLFNGKFFYCSDESKYTQQDCQGQYFVFEDG-ALLPEPKKREWQSQFFHYDNVMAAMLTL 1046
Query: 3019 FVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIVT 3198
F V T EGWPQ+L ++ + EDKGPI N R +++ +I+T
Sbjct: 1047 FAVQTGEGWPQILQNSMAATYEDKGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIIT 1106
Query: 3199 FQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIP--RNRLQYRVWWFVTSRAFEYVIF 3372
FQ +GE E ++ E+DKNQ+ CI+F ++A+P RY+P RN ++Y++W V S FEY I
Sbjct: 1107 FQEQGEAELQDGEIDKNQKSCIDFTIQARPLERYMPKERNSVKYKIWRIVVSTPFEYFIM 1166
Query: 3373 LIIVMNTVSL-----ACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISD 3537
+IV+NTV L A + + S +++ L N+ FTG+F E +LKI A +N+ D
Sbjct: 1167 GLIVLNTVLLMMKCHALQFHRQSDAYKNTLKYMNMCFTGMFTVECILKIAAFGVRNFFKD 1226
Query: 3538 RWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTF 3717
WN FD + V+GS +D + G N I++ F RLFR RL+KLL +G IR LLWTF
Sbjct: 1227 AWNTFDFITVIGSIVDALVIEF---GENFINVGFLRLFRAARLIKLLRQGYTIRILLWTF 1283
Query: 3718 MKSFQALPYVALLIVLLFFIYAVIGM---------------------------------- 3795
++SF+ALPYV LLI +LFFIYA+IGM
Sbjct: 1284 VQSFKALPYVCLLIAMLFFIYAIIGMQKKKGKTNIEKIVSNDEIGDCGKRVSDIVYRNRM 1343
Query: 3796 -----------------QFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIM 3924
Q FG ++ D T+I +NNF SF A +++LFR ATGEAW +IM
Sbjct: 1344 INGNYKMGPLVTMKFRCQVFGNISNDPGTAIDDHNNFQSFFAGLMLLFRCATGEAWPNIM 1403
Query: 3925 LSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
LSC CD K G E CG+N AY YF+SF CSFL++NLFVAVIMDNF
Sbjct: 1404 LSCVKGRP--CDA------KAGKQEGGCGSNIAYAYFVSFIFFCSFLMLNLFVAVIMDNF 1455
Query: 4105 DYLTRDWSILGP 4140
DYLTRD SILGP
Sbjct: 1456 DYLTRDSSILGP 1467
Score = 127 bits (318), Expect = 4e-27
Identities = 89/350 (25%), Positives = 162/350 (45%), Gaps = 13/350 (3%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+R+ +V + F+F I+ +I + IALA P + +N +L +Y F VF
Sbjct: 820 NPVRRAAHWVVNLRYFDFFIMVVISLSSIALAAEDP--VWEDSPRNEVLNYFDYAFTGVF 877
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTIL----SKMSIQGFDVKALR 570
T+E +LKI+ +G + HP +YLR WNI+D ++V+ VS S +K+LR
Sbjct: 878 TVEMILKIIDLGIILHPGSYLREFWNIMDAVVVICAAVSFAFDMTGSSAGQNLSTIKSLR 937
Query: 571 AFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHST 750
RVLRPL+ + VP L+ V + ++ ++ +++I ++ + I+A+I ++LF GK
Sbjct: 938 VLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVINILIVYILFQFIFAVIAVQLFNGKFFY- 996
Query: 751 CIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFD 930
C +++ + CQ + G W + ++D
Sbjct: 997 ----------------CSDESKYTQQDCQGQYFVFEDGALLPEPKKREW---QSQFFHYD 1037
Query: 931 NFGLAMLTVFQCVSLEGWTDVMYWVNDAV---------GREWPWIYFVTLVILGSFFVLN 1083
N AMLT+F + EGW ++ A R I+++ I+ FF +N
Sbjct: 1038 NVMAAMLTLFAVQTGEGWPQILQNSMAATYEDKGPIQNFRIEMSIFYIVYFIVFPFFFVN 1097
Query: 1084 LVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIE 1233
+ + ++ F ++ E G +++++ K +D+ QA +E
Sbjct: 1098 IFVALIIITFQEQGEAELQDG---------EIDKNQKSCIDFTIQARPLE 1138
Score = 114 bits (286), Expect = 2e-23
Identities = 128/664 (19%), Positives = 257/664 (38%), Gaps = 45/664 (6%)
Frame = +1
Query: 253 VEWKPFEFLILFMICANCIALAI-YQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIV 429
V+ + F + ++ ++ N + +A+ + P +D+ L E+VF+ +F +E +K+
Sbjct: 527 VKSQKFYWFVIVLVFFNTVCVAVEHYGQPQWLTDF----LYFAEFVFLALFMLEMFIKVY 582
Query: 430 AMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSG 609
A+G P Y +++N D +++ + I S++ F + LRA R+LR ++
Sbjct: 583 ALG----PRTYFDSSFNRFDCVVISGSIFEVIWSEVKSGSFGLSVLRALRLLRIFKVTKY 638
Query: 610 VPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKD 789
SL+ ++ ++L +M ++ + L+ ILI+A++G++LF G+ + P T
Sbjct: 639 WKSLRNLVISLLSSMRSIISLLFLLFLFILIFALLGMQLFGGQFNFDSGTPPT------- 691
Query: 790 PTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCV 969
NF+ F +A+LTVFQ +
Sbjct: 692 --------------------------------------------NFNTFPIALLTVFQIL 707
Query: 970 SLEGWTDVMYWVNDAVGREWPW----IYFVTLVILGSFFVLNLVLGVLSGEFSKEREKAR 1137
+ E W +VMY ++ G +YF+ LV+ G++ +LN+ L + + + A
Sbjct: 708 TGEDWNEVMYQGIESQGGHKKGMIYSLYFIVLVLFGNYTLLNVFLAIAVDNLNPKDGGAP 767
Query: 1138 ARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVAQTXXXXXXXXXXXXX 1317
+ Q +D KG + E + +++D+ +
Sbjct: 768 KVEICPP--SPNQNFKDGKG------GKQSSEEEKKQDEDDDTGPKPMLPYSSMFILSPT 819
Query: 1318 XXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSE 1497
+ W ++ + + ++ W E ++E
Sbjct: 820 NPVRRAAHWVVNLRYFDFFIMVVISLSSIALAAEDPVW---------------EDSPRNE 864
Query: 1498 WLDHFQTMANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLV 1665
L++F + F +F++EM+LK+ LG +Y +N D VVI + + F
Sbjct: 865 VLNYF----DYAFTGVFTVEMILKIIDLGIILHPGSYLREFWNIMDAVVVICAAVSFAFD 920
Query: 1666 YFDLMKPLGVSVLRSARLLRI---FKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1836
+S ++S R+LR+ K K
Sbjct: 921 MTGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVINILIVYILFQF 980
Query: 1837 XXXXXGMQVFGGKFNFNPQQ---------------------PKPRA--------NFDTFV 1929
+Q+F GKF + + P+P+ ++D +
Sbjct: 981 IFAVIAVQLFNGKFFYCSDESKYTQQDCQGQYFVFEDGALLPEPKKREWQSQFFHYDNVM 1040
Query: 1930 QALLTVFQILTGEDWNTVMYHGI----ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFL 2097
A+LT+F + TGE W ++ + + E G + + + I+YIV FI + +N+F+
Sbjct: 1041 AAMLTLFAVQTGEGWPQILQNSMAATYEDKGPIQNFRIEMSIFYIVYFIVFPFFFVNIFV 1100
Query: 2098 AIAV 2109
A+ +
Sbjct: 1101 ALII 1104
Score = 104 bits (260), Expect = 2e-20
Identities = 85/358 (23%), Positives = 163/358 (44%), Gaps = 24/358 (6%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIY---QPYPAQDSDYKNTLLETIEYVFI 393
N ++ IV PFE+ I+ +I N + L + + Q YKNTL + + F
Sbjct: 1146 NSVKYKIWRIVVSTPFEYFIMGLIVLNTVLLMMKCHALQFHRQSDAYKNTL-KYMNMCFT 1204
Query: 394 VVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRA 573
+FT+EC+LKI A G + ++AWN DFI V+ +V ++ + +V LR
Sbjct: 1205 GMFTVECILKIAAFGVR----NFFKDAWNTFDFITVIGSIVDALVIEFGENFINVGFLRL 1260
Query: 574 FRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTC 753
FR R ++L+ +++++L +++ L ++ LL+ + IYAIIG++ GK +
Sbjct: 1261 FRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQKKKGKTNIEK 1320
Query: 754 IDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMG----VRWEC---SSNTTWPGPN- 909
I ++ + CG ++ + + MG +++ C + + PG
Sbjct: 1321 I------VSNDEIGDCGKRVSDIVYRNRMINGNYKMGPLVTMKFRCQVFGNISNDPGTAI 1374
Query: 910 NGITNFDNFGLAMLTVFQCVSLEGWTDVMYWV-------------NDAVGREWPWIYFVT 1050
+ NF +F ++ +F+C + E W ++M G + YFV+
Sbjct: 1375 DDHNNFQSFFAGLMLLFRCATGEAWPNIMLSCVKGRPCDAKAGKQEGGCGSNIAYAYFVS 1434
Query: 1051 LVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAE 1224
+ SF +LNL + V+ F + G ++ + +++L + ++ W QA+
Sbjct: 1435 FIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGPPRETKRREELRDTIRSI--WPLQAK 1490
Score = 96.7 bits (239), Expect = 6e-18
Identities = 45/97 (46%), Positives = 61/97 (62%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N IRK I+EW PFE+ +L I ANC+ LA+ + P QD LE E F+ +
Sbjct: 154 DNCIRKHTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPKQDKTILAQKLEATEIYFLGI 213
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIG 510
F +E LKI+A+GF+ H +YLRN WNI+DF +VV G
Sbjct: 214 FCVEASLKILALGFVLHRGSYLRNIWNIMDFFVVVTG 250
Score = 67.0 bits (162), Expect = 5e-09
Identities = 36/102 (35%), Positives = 55/102 (53%), Gaps = 2/102 (1%)
Frame = +1
Query: 2326 SSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAED--PLQANSTRNMILNY 2499
+SLFILS N R ++ F AVL I+ + +LA E+ P Q + L
Sbjct: 146 TSLFILSEDNCIRKHTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPKQDKTILAQKLEA 205
Query: 2500 FDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
+ +F +F VE +LK++ G V H+GS+ RN +N++D VV
Sbjct: 206 TEIYFLGIFCVEASLKILALGFVLHRGSYLRNIWNIMDFFVV 247
Score = 45.4 bits (106), Expect = 0.016
Identities = 29/79 (36%), Positives = 41/79 (51%), Gaps = 7/79 (8%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSSRG--FEDFLDVFNLIFTGVFAFEAVLKIVA----L 3513
FEY + L I+ N V LA + H P L+ + F G+F EA LKI+A L
Sbjct: 170 FEYAVLLTIIANCVVLALEEHLPKQDKTILAQKLEATEIYFLGIFCVEASLKILALGFVL 229
Query: 3514 NPKNYISDRWNVFDLLVVV 3570
+ +Y+ + WN+ D VVV
Sbjct: 230 HRGSYLRNIWNIMDFFVVV 248
Score = 38.1 bits (87), Expect = 2.5
Identities = 66/264 (25%), Positives = 102/264 (38%), Gaps = 52/264 (19%)
Frame = +1
Query: 4414 EQLRSAIKRIWKRTHKDLLDEVVPPAGK--EDDVTVGKFYATFLIQDYFRRFKKRKEMEA 4587
E+LR I+ IW K +LD ++P + +TVGK Y LI + +R + ++E+
Sbjct: 1475 EELRDTIRSIWPLQAKKMLDLLIPRNEEIGRGKMTVGKIYVCLLILESWRT-TRFGQIES 1533
Query: 4588 KGV---------LPAQTPQAMALQAGLRTLHEI---------------GPELKRAISGNL 4695
G Q+P A A+QA L + ++ L+ +
Sbjct: 1534 AGQNDNDLIDNDNAGQSPAAQAVQAFLNCILDVTAVNHTGNNHGAGSRANSLEHVVRPTP 1593
Query: 4696 ETDFN----FDEPEPQHRRPHSLFNNLV-----HRLSGAGSKSPTEHERIEKGSTLLPF- 4845
ET + E + +HRR S+ N V H+ GS E + GS ++P
Sbjct: 1594 ETKLDQHKEHREEDDEHRRQRSIRNKKVNWKMSHQYDILGSSG--ESSQGGGGSGVVPVV 1651
Query: 4846 --QPRSFSPTHSLAGAE----------GSPVPSQMHRGA---PINQSINLPPVNGSARR- 4977
+ R+ LA E + S H G P Q + P + S RR
Sbjct: 1652 NDEDRAPELEPLLAEMELQDVVVSDSRAGSLESLTHTGKRLHPPVQPVRHPSRSPSLRRH 1711
Query: 4978 LPALPPYANHIHDETDDGPRYRDT 5049
P P Y +H H +GP + DT
Sbjct: 1712 SPGRPGYDHHGH-YYHEGPGFSDT 1734
>gi|47207166|emb|CAG06208.1| unnamed protein product [Tetraodon
nigroviridis]
Length = 1655
Score = 804 bits (2076), Expect = 0.0
Identities = 417/765 (54%), Positives = 520/765 (67%), Gaps = 35/765 (4%)
Frame = +1
Query: 2488 ILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAM 2667
IL Y DY FTS+FTVEI LK+ V G H+GSFCRN FNLLD+LVV+VSL SF L + A+
Sbjct: 567 ILGYADYAFTSIFTVEILLKMTVHGAFLHQGSFCRNWFNLLDLLVVSVSLVSFFLHSSAI 626
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
S AINRAKGLKHVVQCV VA++TIGNIM+VT +LQFMFA IGVQLF
Sbjct: 627 SVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLF 686
Query: 2848 KGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVV 3027
KG F+ C D +K T +C+G ++ Y+DGD + P+ ++R+W N+DFNFDNV M++LF V
Sbjct: 687 KGKFYRCTDEAKHTPEQCKGTFVVYKDGDVSHPMVRERIWHNSDFNFDNVLMGMMALFTV 746
Query: 3028 STFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIVTFQN 3207
STFEGWP LLY AID+N E+ GPI+N R +++ GFVI+TF+
Sbjct: 747 STFEGWPALLYKAIDANGENSGPIYNYRVEISIFFIVYIIIIAFFMMNIFVGFVIITFRE 806
Query: 3208 EGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVM 3387
+GE+EY+NCELDKNQR+C+E+ALKA+P + YIP+N +QY+ W + S FEYV+F++I++
Sbjct: 807 QGEQEYKNCELDKNQRQCVEYALKAQPLKLYIPKNPVQYKFWAIINSTGFEYVMFVLILL 866
Query: 3388 NTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVV 3567
NTV+LA +HY S+ F +D+ N++FTG+F E +LK++AL P++Y D WN FD L+V
Sbjct: 867 NTVTLAIQHYEQSKTFSHVMDILNMVFTGLFTVEMLLKLLALRPRHYFVDAWNSFDALIV 926
Query: 3568 VGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYV 3747
VGS +DI + F ALPYV
Sbjct: 927 VGSVVDIV------------------------------------------VTEFSALPYV 944
Query: 3748 ALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIML 3927
ALLI ++FFIYAVIGMQ FGK+A+ D T I+RNNNF +FP A+L+LFR ATGEAWQ+IML
Sbjct: 945 ALLIAMIFFIYAVIGMQTFGKIAMQDYTQINRNNNFQTFPQAVLLLFRCATGEAWQEIML 1004
Query: 3928 SCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLV------------- 4068
+ + RCDP S DY G E CG+NFA YFISFFMLC+FLV
Sbjct: 1005 ASLPGK--RCDPES-DYEPG--EEFSCGSNFAIVYFISFFMLCAFLVRKHTHTHTHTHTH 1059
Query: 4069 ----------------------INLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYD 4182
INLFVAVIMDNFDYLTRDWSILGPH L+EF R+WSEYD
Sbjct: 1060 TRTHTHTHAQRHHTLTFLPLQIINLFVAVIMDNFDYLTRDWSILGPHRLDEFKRIWSEYD 1119
Query: 4183 PDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFAL 4362
P+AKGRIKHLDVV LLR+I PPLGFGKLCPHR+ACKRLV+MNMPLNSDG V FNATLFAL
Sbjct: 1120 PEAKGRIKHLDVVALLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGMVTFNATLFAL 1179
Query: 4363 VRTNLKIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLI 4542
VRT LKI TEG ++ NE+LR+ IK+IWKR LLDEV+PP KE++VTVGKFYATFLI
Sbjct: 1180 VRTALKIKTEGIPEQENEELRAIIKKIWKRMKPKLLDEVIPP-HKEEEVTVGKFYATFLI 1238
Query: 4543 QDYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKR 4677
QDYFR+F+KRKE KG +T + +++ ++ GPE R
Sbjct: 1239 QDYFRKFRKRKE---KGNFAGETDDTN--PSAVQSENDFGPEKDR 1278
Score = 457 bits (1177), Expect = e-126
Identities = 252/495 (50%), Positives = 302/495 (60%), Gaps = 21/495 (4%)
Frame = +1
Query: 547 GFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLEL 726
G DVKALRAFRVLRPLRLVSGVPSLQ+VLN+I++AM+PLLHIALLVLFVI+IYAIIGLEL
Sbjct: 28 GLDVKALRAFRVLRPLRLVSGVPSLQIVLNSIMKAMVPLLHIALLVLFVIIIYAIIGLEL 87
Query: 727 FCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGP 906
F G++H TC T + DP PC G +C + S EC W GP
Sbjct: 88 FIGRMHKTCYYTTTDNYVEDDPVPCAFAGHGR--QCVVNGS--------ECRGR--WDGP 135
Query: 907 NNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNL 1086
N GITNFDNF AMLTVFQC+++EGWTDV+YW+NDA+G E PW+YFV+LVI GSFFVLNL
Sbjct: 136 NGGITNFDNFFFAMLTVFQCITMEGWTDVLYWMNDAIGFELPWVYFVSLVIFGSFFVLNL 195
Query: 1087 VLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNED------ 1248
VLGVLSGEFSKEREKA+ARG FQK REKQQ+EEDL GY+DWITQAED++ ++ED
Sbjct: 196 VLGVLSGEFSKEREKAKARGDFQKLREKQQMEEDLCGYMDWITQAEDMDDLDEDGNPRKT 255
Query: 1249 ----------EQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMK-----RLEKLNXX 1383
+ P ++T + W+ MK L + N
Sbjct: 256 STLELGLLSPPKASLPASET--ASENTVNIDEEHTNCCQACWSRVMKISCCRTLRRWNRV 313
Query: 1384 XXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEML 1563
VKS TFYW SEHY Q WL Q +AN + LF++EML
Sbjct: 314 CRRNCRTAVKSTTFYWVVLLLVFLNTSLSASEHYNQPLWLTQVQDIANKVLLSLFTVEML 373
Query: 1564 LKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTK 1743
LKMYSLG Y + FNRFDCFVV I+E +LV ++M PLG+SVLR RLLRIF+VT+
Sbjct: 374 LKMYSLGLAHYFVAFFNRFDCFVVCGGIVETILVEMEIMPPLGISVLRCVRLLRIFRVTR 433
Query: 1744 YWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDT 1923
+WT GMQ+FGGKFNF+ Q K R+ FD+
Sbjct: 434 HWTALSGLVASLLNSMKSIASLLLLLFLFLIIFALLGMQLFGGKFNFDETQTK-RSTFDS 492
Query: 1924 FVQALLTVFQILTGE 1968
F QALLT FQ G+
Sbjct: 493 FPQALLTCFQERDGQ 507
Score = 107 bits (266), Expect = 4e-21
Identities = 79/275 (28%), Positives = 132/275 (47%), Gaps = 9/275 (3%)
Frame = +1
Query: 334 PAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGL 513
P QD +L +Y F +FT+E +LK+ G H ++ RN +N+LD ++V + L
Sbjct: 561 PEQDQP----ILGYADYAFTSIFTVEILLKMTVHGAFLHQGSFCRNWFNLLDLLVVSVSL 616
Query: 514 VSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFV 693
VS L +I VK LR RVLRPLR ++ L+ V+ + A+ + +I ++ +
Sbjct: 617 VSFFLHSSAIS--VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLL 674
Query: 694 ILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRW 873
++A IG++LF GK + C D A+ P C F +++ VR
Sbjct: 675 QFMFACIGVQLFKGKFY-RCTDE-----AKHTPEQC-----KGTFVVYKDGDVSHPMVR- 722
Query: 874 ECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIY---- 1041
W +N NFDN + M+ +F + EGW ++Y DA G IY
Sbjct: 723 ----ERIW---HNSDFNFDNVLMGMMALFTVSTFEGWPALLYKAIDANGENSGPIYNYRV 775
Query: 1042 -----FVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
F+ +I+ +FF++N+ +G + F ++ E+
Sbjct: 776 EISIFFIVYIIIIAFFMMNIFVGFVIITFREQGEQ 810
Score = 83.6 bits (205), Expect = 5e-14
Identities = 51/190 (26%), Positives = 93/190 (48%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S F +V+ L++ +NT A +HY D+ N + +F E +LK+ +L
Sbjct: 322 VKSTTFYWVVLLLVFLNTSLSASEHYNQPLWLTQVQDIANKVLLSLFTVEMLLKMYSLGL 381
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+Y +N FD VV G ++ ++ + I+ R R++R+ ++ +
Sbjct: 382 AHYFVAFFNRFDCFVVCGGIVETILVEMEI--MPPLGISVLRCVRLLRIFRVTRHWTALS 439
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAIL 3879
L+ + + S +++ + LL+ L I+A++GMQ FG D T R + F SFP A+L
Sbjct: 440 GLVASLLNSMKSIASLLLLLFLFLIIFALLGMQLFGGKFNFDETQTKR-STFDSFPQALL 498
Query: 3880 VLFRSATGEA 3909
F+ G++
Sbjct: 499 TCFQERDGQS 508
Score = 64.3 bits (155), Expect = 3e-08
Identities = 45/176 (25%), Positives = 92/176 (51%), Gaps = 1/176 (0%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
N R+ C + V+ F +++L ++ N +L+ + Y + + + V + +
Sbjct: 311 NRVCRRNCRTAVKSTTFYWVVLLLVFLNT-SLSASEHY--NQPLWLTQVQDIANKVLLSL 367
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQ-GFDVKALRAF 576
FT+E +LK+ ++G + A+ +N D +V G+V TIL +M I + LR
Sbjct: 368 FTVEMLLKMYSLGLAHYFVAF----FNRFDCFVVCGGIVETILVEMEIMPPLGISVLRCV 423
Query: 577 RVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLH 744
R+LR R+ +L ++ ++L +M + + LL+ ++I+A++G++LF GK +
Sbjct: 424 RLLRIFRVTRHWTALSGLVASLLNSMKSIASLLLLLFLFLIIFALLGMQLFGGKFN 479
Score = 63.5 bits (153), Expect = 6e-08
Identities = 45/170 (26%), Positives = 71/170 (41%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HY QS+ H + N+ F LF++EMLLK+ +L Y +N FD +V+ S+++
Sbjct: 874 QHYEQSKTFSHVMDILNMVFTGLFTVEMLLKLLALRPRHYFVDAWNSFDALIVVGSVVDI 933
Query: 1657 VLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1836
V+ F + + + + A + I+ V
Sbjct: 934 VVTEFSALPYVALLI---AMIFFIYAV--------------------------------- 957
Query: 1837 XXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVM 1986
GMQ FG + Q NF TF QA+L +F+ TGE W +M
Sbjct: 958 ----IGMQTFGKIAMQDYTQINRNNNFQTFPQAVLLLFRCATGEAWQEIM 1003
Score = 59.7 bits (143), Expect = 8e-07
Identities = 57/258 (22%), Positives = 101/258 (39%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP++ +I+ FE+++ +I N + LAI Q Y + S + +++ + VF +F
Sbjct: 841 NPVQYKFWAIINSTGFEYVMFVLILLNTVTLAI-QHY--EQSKTFSHVMDILNMVFTGLF 897
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
T+E +LK++A+ P Y +AWN D +IVV +V ++++ S
Sbjct: 898 TVEMLLKLLAL----RPRHYFVDAWNSFDALIVVGSVVDIVVTEFS-------------- 939
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
L ++ALL+ + IYA+IG++ F
Sbjct: 940 -------------------------ALPYVALLIAMIFFIYAVIGMQTF----------- 963
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
G++A +D T N NF F
Sbjct: 964 --GKIAMQDYTQI------------------------------------NRNNNFQTFPQ 985
Query: 943 AMLTVFQCVSLEGWTDVM 996
A+L +F+C + E W ++M
Sbjct: 986 AVLLLFRCATGEAWQEIM 1003
Score = 55.8 bits (133), Expect = 1e-05
Identities = 45/203 (22%), Positives = 81/203 (39%), Gaps = 37/203 (18%)
Frame = +1
Query: 3607 PGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAV 3786
PG + + R FRV+R ++L+S ++ +L + MK+ L ++ALL++ + IYA+
Sbjct: 23 PGKPGGLDVKALRAFRVLRPLRLVSGVPSLQIVLNSIMKAMVPLLHIALLVLFVIIIYAI 82
Query: 3787 IGMQFF-----------------------------GKVALDDSTSIHRN--------NNF 3855
IG++ F G+ + + + NF
Sbjct: 83 IGLELFIGRMHKTCYYTTTDNYVEDDPVPCAFAGHGRQCVVNGSECRGRWDGPNGGITNF 142
Query: 3856 HSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYF 4035
+F A+L +F+ T E W D++ +D G + YF
Sbjct: 143 DNFFFAMLTVFQCITMEGWTDVLYWMND---------------------AIGFELPWVYF 181
Query: 4036 ISFFMLCSFLVINLFVAVIMDNF 4104
+S + SF V+NL + V+ F
Sbjct: 182 VSLVIFGSFFVLNLVLGVLSGEF 204
Score = 45.1 bits (105), Expect = 0.020
Identities = 23/64 (35%), Positives = 37/64 (56%)
Frame = +1
Query: 1912 NFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNV 2091
NFD F A+LTVFQ +T E W V+Y ++ G + +Y++ L I G++ +LN+
Sbjct: 141 NFDNFFFAMLTVFQCITMEGWTDVLYWMNDAIG-----FELPWVYFVSLVIFGSFFVLNL 195
Query: 2092 FLAI 2103
L +
Sbjct: 196 VLGV 199
Score = 44.7 bits (104), Expect = 0.027
Identities = 50/234 (21%), Positives = 85/234 (35%), Gaps = 38/234 (16%)
Frame = +1
Query: 1522 ANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPL 1689
A+ F +F++E+LLKM G ++ + FN D VV S++ F L +
Sbjct: 571 ADYAFTSIFTVEILLKMTVHGAFLHQGSFCRNWFNLLDLLVVSVSLVSFFLHSSAISV-- 628
Query: 1690 GVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFG 1869
V +LR R+LR + G+Q+F
Sbjct: 629 -VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFK 687
Query: 1870 GKF-------NFNPQQPKPRA-----------------------NFDTFVQALLTVFQIL 1959
GKF P+Q K NFD + ++ +F +
Sbjct: 688 GKFYRCTDEAKHTPEQCKGTFVVYKDGDVSHPMVRERIWHNSDFNFDNVLMGMMALFTVS 747
Query: 1960 TGEDWNTVMYHGI----ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
T E W ++Y I E+ G + V + I++IV I + ++N+F+ +
Sbjct: 748 TFEGWPALLYKAIDANGENSGPIYNYRVEISIFFIVYIIIIAFFMMNIFVGFVI 801
>gi|2133450|pir||S58883 calcium-channel homolog - Caenorhabditis
elegans (fragment)
gi|841434|gb|AAA85728.1| Unc-2
gi|1096086|prf||2110386A Ca channel
Length = 1053
Score = 794 bits (2051), Expect = 0.0
Identities = 447/1052 (42%), Positives = 603/1052 (56%), Gaps = 24/1052 (2%)
Frame = +1
Query: 1405 LVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLG 1584
+VK+Q FYW SEHYGQ +W F A F+ +F +EMLLK++++G
Sbjct: 6 MVKTQIFYWSVITLVFLNTCCVASEHYGQPQWFTDFLKYAEFVFLGIFVVEMLLKLFAMG 65
Query: 1585 FTTYTTSQFNRFDCFVVISSILEFVL--VYFDLMKPLGVSVLRSARLLRIFKVTKYWTXX 1758
TY S+FNRFDC V++ S E + VY G+SV+R+ RLLRIFK+T YW
Sbjct: 66 SRTYFASKFNRFDCVVIVGSAAEVIWAEVYGG---SFGISVMRALRLLRIFKLTSYWVSL 122
Query: 1759 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQAL 1938
GMQ+FGG+FNF P +FDTF AL
Sbjct: 123 RNLVRSLMNSMRSIISLLFLLFLFILIFALLGMQLFGGRFNFPTMHPY--THFDTFPVAL 180
Query: 1939 LTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNL 2118
+TVFQILTGEDWN VMY IES GG+ + G IY+IVL + GNY LLNVFLAIAVDNL
Sbjct: 181 ITVFQILTGEDWNEVMYLAIESQGGIYSGGWPYSIYFIVLVLFGNYTLLNVFLAIAVDNL 240
Query: 2119 ADADSLTNAXXXXXXXXXXXXXXXXXX---------XXXXXXXXXXXXXXXXXXMTSARP 2271
A+A LT A M
Sbjct: 241 ANAQELTAAEEADEKANEIEEESEELDEQYQEGDHCTIDMEGKTAGDMCAVARAMDDLDE 300
Query: 2272 RRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAA 2451
E KP+ SS+F LS TN FRV + +V YF V+ I +SS LAA
Sbjct: 301 ECEEEESPFGGPKPMVPYSSMFFLSPTNPFRVLIHSIVCTKYFEMMVMTVICLSSVSLAA 360
Query: 2452 EDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAV 2631
EDP+ + RN +L Y DY FT V E+ LK+I G++ H GS+CR+ +N+LD +VV
Sbjct: 361 EDPVDEENPRNKVLQYMDYCFTGVLACEMLLKLIDQGILLHPGSYCRDFWNILDGIVVTC 420
Query: 2632 SLTSFVLRTDAMSXXXXXXXXXXXXXXXA------INRAKGLKHVVQCVIVAVKTIGNIM 2793
+L +F S I R LK V CV+ ++K + NI+
Sbjct: 421 ALFAFGFAGTEGSAGKNLNTIKSLRVLRVLRPLKTIKRIPKLKAVFDCVVNSLKNVFNIL 480
Query: 2794 LVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYED-GDPTKPVSKKRVWS 2970
+V F+ QF+FA+I VQLF G FF C D ++ C G++ Y++ DP P ++R W
Sbjct: 481 IVYFLFQFIFAVIAVQLFNGKFFFCTDKNRKFANTCHGQFFVYDNQNDP--PRVEQREWR 538
Query: 2971 NNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXX 3150
FN+DN +AM++LFVV+T EGWP + ++D+ ED+GP R VAL
Sbjct: 539 LRPFNYDNTINAMLTLFVVTTGEGWPGIRQNSMDTTFEDQGPSPFFRVEVALFYVMFFIV 598
Query: 3151 XXXXXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIP--RNRLQY 3324
+I+TFQ +GE E +LDKNQ++CI+F L A+P ++P +N +Y
Sbjct: 599 FPFFFVNIFVALIIITFQEQGEAELSEGDLDKNQKQCIDFGLNARPRSLFMPEDKNSTKY 658
Query: 3325 RVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKI 3504
R+W VTS FEY I +I NT+ L K+Y + +E+ L +FN T VF E++LKI
Sbjct: 659 RIWRLVTSPPFEYFIMTMICCNTLILMMKYYNNPLFYEEILRLFNTALTAVFTVESILKI 718
Query: 3505 VALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSR 3684
+A +NY D WN FD + VVGS D + G + +S+ F RLFR RL++LL +
Sbjct: 719 LAFGVRNYFRDGWNRFDFVTVVGSITDALVTEF---GGHFVSLGFLRLFRAARLIRLLQQ 775
Query: 3685 GEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSF 3864
G IR LLWTF++SF+ALPYV LLI +LFFIYA++GMQ FG + L+ +T I+R+NNF SF
Sbjct: 776 GYTIRILLWTFVQSFKALPYVCLLIGMLFFIYAIVGMQVFGNIWLNAATEINRHNNFQSF 835
Query: 3865 PAAILVLFRSATGEAWQDIMLSCSDRED-VRCDPMSDDYHKGGLNESRCGNNFAYPYFIS 4041
A+++LFR ATGE WQDIM++ +D R ++ KG CG+N +Y YF S
Sbjct: 836 FNAVILLFRCATGEGWQDIMMAAVQGKDCARAGSAEINFEKG----QTCGSNVSYAYFTS 891
Query: 4042 FFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVV 4221
F L SFL++NLFVAVIMDNFDYLTRD SILGPHHL+EF+R+W++YDP A GRI + ++
Sbjct: 892 FVFLSSFLMLNLFVAVIMDNFDYLTRDSSILGPHHLDEFIRVWADYDPAATGRIHYSEMY 951
Query: 4222 TLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNL--KIYTEG 4395
+LR ++PP+GFGK CP+RLA K L+ MNMP+ DGTV F TLFAL+R +L K+
Sbjct: 952 EMLRIMAPPVGFGKKCPYRLAYKHLIRMNMPVAEDGTVHFTTTLFALIRESLSIKMRPVE 1011
Query: 4396 NIDEANEQLRSAIKRIWK-RTHKDLLDEVVPP 4488
+DEA+E+LR +K+IW + K+++D VVPP
Sbjct: 1012 EMDEADEELRLTLKKIWPLKAKKNMVDLVVPP 1043
Score = 125 bits (314), Expect = 1e-26
Identities = 72/265 (27%), Positives = 139/265 (52%), Gaps = 3/265 (1%)
Frame = +1
Query: 3316 LQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAV 3495
+Q R+ V ++ F + + ++ +NT +A +HY + F DFL +F G+F E +
Sbjct: 1 IQIRI--MVKTQIFYWSVITLVFLNTCCVASEHYGQPQWFTDFLKYAEFVFLGIFVVEML 58
Query: 3496 LKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKL 3675
LK+ A+ + Y + ++N FD +V+VGS ++ + ++ G I+ R R++R+ KL
Sbjct: 59 LKLFAMGSRTYFASKFNRFDCVVIVGSAAEVIWAEVYGGS---FGISVMRALRLLRIFKL 115
Query: 3676 LSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNF 3855
S +R L+ + M S +++ + L+ L I+A++GMQ FG + ++H +F
Sbjct: 116 TSYWVSLRNLVRSLMNSMRSIISLLFLLFLFILIFALLGMQLFG--GRFNFPTMHPYTHF 173
Query: 3856 HSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYF 4035
+FP A++ +F+ TGE W ++M + + GG+ +PY
Sbjct: 174 DTFPVALITVFQILTGEDWNEVMYLAIESQ-------------GGIYSG------GWPYS 214
Query: 4036 ISFFMLC---SFLVINLFVAVIMDN 4101
I F +L ++ ++N+F+A+ +DN
Sbjct: 215 IYFIVLVLFGNYTLLNVFLAIAVDN 239
Score = 110 bits (276), Expect = 3e-22
Identities = 89/336 (26%), Positives = 155/336 (45%), Gaps = 16/336 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP R L SIV K FE +++ +IC + ++LA P + + +N +L+ ++Y F V
Sbjct: 328 NPFRVLIHSIVCTKYFEMMVMTVICLSSVSLAAEDP--VDEENPRNKVLQYMDYCFTGVL 385
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGF------DVKA 564
E +LK++ G + HP +Y R+ WNILD I+V L + +G +K+
Sbjct: 386 ACEMLLKLIDQGILLHPGSYCRDFWNILDGIVVTCALFA--FGFAGTEGSAGKNLNTIKS 443
Query: 565 LRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLH 744
LR RVLRPL+ + +P L+ V + ++ ++ + +I ++ I+A+I ++LF GK
Sbjct: 444 LRVLRVLRPLKTIKRIPKLKAVFDCVVNSLKNVFNILIVYFLFQFIFAVIAVQLFNGKFF 503
Query: 745 STCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVR-WECSSNTTWPGPNNGIT 921
C D +K C G F + + R W
Sbjct: 504 -FCTDK-----NRKFANTC----HGQFFVYDNQNDPPRVEQREWRLRP-----------F 542
Query: 922 NFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREW---PW------IYFVTLVILGSFF 1074
N+DN AMLT+F + EGW + D + P+ +++V I+ FF
Sbjct: 543 NYDNTINAMLTLFVVTTGEGWPGIRQNSMDTTFEDQGPSPFFRVEVALFYVMFFIVFPFF 602
Query: 1075 VLNLVLGVLSGEFSKEREKARARGLFQKFREKQQLE 1182
+N+ + ++ F ++ E + G K +KQ ++
Sbjct: 603 FVNIFVALIIITFQEQGEAELSEGDLDK-NQKQCID 637
Score = 102 bits (254), Expect = 1e-19
Identities = 75/320 (23%), Positives = 148/320 (45%), Gaps = 6/320 (1%)
Frame = +1
Query: 250 IVEWKPFEFLILFMICAN-CIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKI 426
+V+ + F + ++ ++ N C + + P +D+ L+ E+VF+ +F +E +LK+
Sbjct: 6 MVKTQIFYWSVITLVFLNTCCVASEHYGQPQWFTDF----LKYAEFVFLGIFVVEMLLKL 61
Query: 427 VAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVS 606
AMG Y + +N D +++V I +++ F + +RA R+LR +L S
Sbjct: 62 FAMG----SRTYFASKFNRFDCVVIVGSAAEVIWAEVYGGSFGISVMRALRLLRIFKLTS 117
Query: 607 GVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQK 786
SL+ ++ +++ +M ++ + L+ ILI+A++G++LF G+ + + P T
Sbjct: 118 YWVSLRNLVRSLMNSMRSIISLLFLLFLFILIFALLGMQLFGGRFNFPTMHPYT------ 171
Query: 787 DPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQC 966
+FD F +A++TVFQ
Sbjct: 172 ---------------------------------------------HFDTFPVALITVFQI 186
Query: 967 VSLEGWTDVMYWVNDAVG----REWPW-IYFVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
++ E W +VMY ++ G WP+ IYF+ LV+ G++ +LN+ L + + +E
Sbjct: 187 LTGEDWNEVMYLAIESQGGIYSGGWPYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQEL 246
Query: 1132 ARARGLFQKFREKQQLEEDL 1191
A +K E ++ E+L
Sbjct: 247 TAAEEADEKANEIEEESEEL 266
Score = 86.7 bits (213), Expect = 6e-15
Identities = 73/307 (23%), Positives = 124/307 (39%), Gaps = 19/307 (6%)
Frame = +1
Query: 250 IVEWKPFEFLILFMICANCIALAI-YQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKI 426
+V PFE+ I+ MIC N + L + Y P + +L VFT+E +LKI
Sbjct: 663 LVTSPPFEYFIMTMICCNTLILMMKYYNNPL----FYEEILRLFNTALTAVFTVESILKI 718
Query: 427 VAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVS 606
+A G Y R+ WN DF+ VV + ++++ + LR FR R +RL+
Sbjct: 719 LAFGVR----NYFRDGWNRFDFVTVVGSITDALVTEFGGHFVSLGFLRLFRAARLIRLLQ 774
Query: 607 GVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQK 786
+++++L +++ L ++ LL+ + IYAI+G+++F
Sbjct: 775 QGYTIRILLWTFVQSFKALPYVCLLIGMLFFIYAIVGMQVF------------------- 815
Query: 787 DPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQC 966
G W + T +N +F N A++ +F+C
Sbjct: 816 -------------------------GNIW--LNAATEINRHNNFQSFFN---AVILLFRC 845
Query: 967 VSLEGWTDVM------------------YWVNDAVGREWPWIYFVTLVILGSFFVLNLVL 1092
+ EGW D+M + G + YF + V L SF +LNL +
Sbjct: 846 ATGEGWQDIMMAAVQGKDCARAGSAEINFEKGQTCGSNVSYAYFTSFVFLSSFLMLNLFV 905
Query: 1093 GVLSGEF 1113
V+ F
Sbjct: 906 AVIMDNF 912
Score = 48.5 bits (114), Expect = 0.002
Identities = 48/236 (20%), Positives = 101/236 (42%), Gaps = 3/236 (1%)
Frame = +1
Query: 2377 MVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIV 2556
++V F +V+ + +++ +A+E Q + L Y ++ F +F VE+ LK+
Sbjct: 5 IMVKTQIFYWSVITLVFLNTCCVASEHYGQPQWFTDF-LKYAEFVFLGIFVVEMLLKLFA 63
Query: 2557 FGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAK- 2733
G ++ + FN D +V+ S V+ +
Sbjct: 64 MG----SRTYFASKFNRFDCVVIVGSAAE-VIWAEVYGGSFGISVMRALRLLRIFKLTSY 118
Query: 2734 --GLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRG 2907
L+++V+ ++ ++++I +++ + F+ +FA++G+QLF G F
Sbjct: 119 WVSLRNLVRSLMNSMRSIISLLFLLFLFILIFALLGMQLFGGRF----------NFPTMH 168
Query: 2908 EYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
Y H++ T PV A+I++F + T E W +++Y+AI+S
Sbjct: 169 PYTHFD----TFPV------------------ALITVFQILTGEDWNEVMYLAIES 202
>gi|47220469|emb|CAG03249.1| unnamed protein product [Tetraodon
nigroviridis]
Length = 2340
Score = 778 bits (2009), Expect = 0.0
Identities = 400/727 (55%), Positives = 498/727 (68%), Gaps = 72/727 (9%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTN-----------SFRVFCNMVVNHSYFTNAV 2412
RP+R+SE+ + PIP S+ F+ S TN +FRVFC+ ++NH FTN +
Sbjct: 838 RPQRLSELVIKEKIPPIPAGSAFFLFSSTNPLVTKTQEKDRTFRVFCHKLINHQIFTNLI 897
Query: 2413 LFCILVSSAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVI------------- 2553
L I++SS LAAEDP++ S RN+IL YFDY FT++FTVEI LK++
Sbjct: 898 LVFIMLSSVSLAAEDPIRNFSARNIILGYFDYAFTAIFTVEILLKILGYADYVFTSMFTF 957
Query: 2554 -------VFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXX 2712
FG HKG+FCRN FNLLD+LVV VSL SF +++ A+S
Sbjct: 958 EILIKMTAFGAFLHKGAFCRNYFNLLDLLVVGVSLVSFGIQSSAISVVKILRVLRVLRPL 1017
Query: 2713 XAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTE 2892
AINRAKGLKHVVQCV VA++TIGNIM+VT +LQFMFA IGVQLFKG F+ C D +K +
Sbjct: 1018 RAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDDAKSSP 1077
Query: 2893 AECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAID 3072
EC+G YI Y +GD P+ K+R+W N+DFNFDNV AM++LF VSTFEGWP LLY AID
Sbjct: 1078 EECKGTYILYNNGDTAPPMVKERIWYNSDFNFDNVLMAMMALFTVSTFEGWPTLLYKAID 1137
Query: 3073 SNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIVTFQNEGEREYENCELDKNQ 3252
SN+E+ GPI+N R +++ GFVIVTFQ +GE+EY+NCELDKNQ
Sbjct: 1138 SNKENMGPIYNYRIEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQ 1197
Query: 3253 RKCIEFALKAKPHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRG 3432
R+C+E+ALKA+P RRYIP+N QY+ W+ V S FEYV+F++I++NT+ LA +H+ S
Sbjct: 1198 RQCVEYALKARPLRRYIPKNPYQYKFWYVVNSTGFEYVMFILIILNTLCLAIQHHGQSHL 1257
Query: 3433 FEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGK---- 3600
F +D+ N++FTGVF E +LK++A P+ Y+ D WNVFD LVV+GS +DI +
Sbjct: 1258 FNYAMDILNMVFTGVFTVEMILKLIAFKPRGYVGDPWNVFDALVVIGSVVDIILSQNYFA 1317
Query: 3601 ----------------------------------LNPGGTN---LISINFFRLFRVMRLV 3669
++PG T ISI FFRLFRVMRLV
Sbjct: 1318 DAWNTFDALIVVGSVVDIAITEINSATIPVVKVIVDPGNTEDSARISITFFRLFRVMRLV 1377
Query: 3670 KLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNN 3849
KLLSRGEGIRTLLWTF+KSFQALPYVALLI +LFFIYAVIGMQ FGK+A+ D T I+RNN
Sbjct: 1378 KLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQVFGKIAMVDGTQINRNN 1437
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FP A+L+LFR ATGEAWQ+IML+C + CD S DY+ G E CG+ FA
Sbjct: 1438 NFQTFPQAVLMLFRCATGEAWQEIMLACLPGK--LCDSES-DYNPG--EERTCGSGFAIF 1492
Query: 4030 YFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKH 4209
YFISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+WSEYDP+AKGRIKH
Sbjct: 1493 YFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKH 1552
Query: 4210 LDVVTLL 4230
LDVVTLL
Sbjct: 1553 LDVVTLL 1559
Score = 674 bits (1740), Expect = 0.0
Identities = 366/712 (51%), Positives = 441/712 (61%), Gaps = 70/712 (9%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLL---------- 369
NNP+R+ CIS+VEWKPF+ IL I ANC+ALAIY P+P DS+ N L
Sbjct: 76 NNPVRRACISLVEWKPFDIFILLSIFANCVALAIYIPFPGDDSNSTNQELMKMTMEAGVV 135
Query: 370 --------------ETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVI 507
ET+EY F+++FTIE LKI+A G + H ++Y+RN WN+LDF+IV+I
Sbjct: 136 LRLVRGEPAVKSCGETVEYAFLIIFTIETFLKIIAYGLVMHQNSYVRNGWNLLDFVIVII 195
Query: 508 GLVSTILSKMSIQ------------GFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRA 651
GL S L ++ GFDVKALRAFRVLRPLRLVSGVPSLQVVLN+I++A
Sbjct: 196 GLFSVALEMITKDADSSGQSGGKPGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKA 255
Query: 652 MIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFK 831
M+PLLHIALLVLFVI+IYA+IGLELF GK+H+TC TG A+++PTPC G
Sbjct: 256 MVPLLHIALLVLFVIIIYAVIGLELFIGKMHATCYIKETGSFAEEEPTPCAVSGHGR--H 313
Query: 832 CQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVND 1011
C + ++ G W GPNNGITNFDNF AMLTVFQC+++EGWTDV+YW+ND
Sbjct: 314 CLLNGTICREG----------WQGPNNGITNFDNFLFAMLTVFQCITMEGWTDVLYWMND 363
Query: 1012 AVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDL 1191
A+G E PW+YFV+LVI GSFFVLNLVLGVLSGEFSKEREKA+ARG FQK REKQQLEEDL
Sbjct: 364 AMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDL 423
Query: 1192 KGYLDWITQAEDIEPVNEDEQEDE-------PVAQTXXXXXXXXXXXXXXXXXXP----- 1335
KGYLDWITQAEDI+P NE+E E+E P P
Sbjct: 424 KGYLDWITQAEDIDPENEEEGEEEGKRNPSMPSETESVNTDNHAGADDKSSCCGPLCQKI 483
Query: 1336 --SKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDH 1509
SK++ + +R N VKS FYW SEHY Q +WL
Sbjct: 484 TKSKFSRQWRR---WNRFCRRKCRAAVKSVIFYWLVIILVFLNTLTIASEHYNQPDWLTE 540
Query: 1510 FQ--------------------TMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCF 1629
Q +AN + +F++EML+KMYSLG Y S FNRFDCF
Sbjct: 541 VQGGSCSDPPAHRTHSQAQRCSEVANKVLLAMFTLEMLVKMYSLGLQAYFVSLFNRFDCF 600
Query: 1630 VVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXX 1809
VV I+E +LV +M PLG+SV R RLLRIFKVT++W
Sbjct: 601 VVCGGIVETILVELAIMSPLGISVFRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASL 660
Query: 1810 XXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMY 1989
GMQ+FGGKFNF+ K R+ FD F QALLTVFQILTGEDWNTVMY
Sbjct: 661 LLLLFLFIIIFSLLGMQLFGGKFNFDETVTK-RSTFDNFPQALLTVFQILTGEDWNTVMY 719
Query: 1990 HGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNA 2145
GI ++GG + G++V IY+I+LFICGNYILLNVFLAIAVDNLADA+SL A
Sbjct: 720 DGIMAYGGPASSGMLVSIYFIILFICGNYILLNVFLAIAVDNLADAESLNTA 771
Score = 212 bits (540), Expect = 7e-53
Identities = 132/274 (48%), Positives = 164/274 (59%), Gaps = 49/274 (17%)
Frame = +1
Query: 4243 PPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEG--------- 4395
PPLGFGKLCPHR+ACKRLV+MNMPLNSDGTV FNATLFALVRT LKI TEG
Sbjct: 1630 PPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGESGPFICII 1689
Query: 4396 -------------------------NIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKE 4500
N+D+ANE+LR IK+IWKRT LLD+VVPPAG +
Sbjct: 1690 QDFALQSSISRNGDYQHPYIFTLLGNLDQANEELRIVIKKIWKRTSMKLLDQVVPPAG-D 1748
Query: 4501 DDVTVGKFYATFLIQDYFRRFKKRKEMEAKG------VLPAQTPQAMALQAGLRTLHEIG 4662
D+VTVGKFYATFLIQDYFR+FK+RKE G + Q ++LQAGLRTLH+IG
Sbjct: 1749 DEVTVGKFYATFLIQDYFRKFKRRKEQGLVGKRSWERLNTTMALQPLSLQAGLRTLHDIG 1808
Query: 4663 PELKRAISGNLE----TDFNFDEPEPQ-HRRPHSLFNNLVHRLSGAGSKSPTEHERIEKG 4827
PE++RAIS +L+ + + DE E Q +RR LF N ++ +S ++
Sbjct: 1809 PEIRRAISCDLQQEGLVEGHEDEEEEQIYRRNGGLFGNYMNHVSADKQGYSHLTTVTQRP 1868
Query: 4828 STLLPFQ-PRSFSPTH---SLAGAEGSPVPSQMH 4917
+LP + PT S +G E + PS +H
Sbjct: 1869 LQILPLSCSAAVEPTSTEGSASGEERAKNPSPIH 1902
Score = 115 bits (289), Expect = 9e-24
Identities = 91/328 (27%), Positives = 156/328 (46%), Gaps = 28/328 (8%)
Frame = +1
Query: 232 RKLCISIVEWKPFEFLILFMICANCIALAIYQP---YPAQDS-----DYKNTLLETIE-- 381
R C ++ + F LIL I + ++LA P + A++ DY T + T+E
Sbjct: 881 RVFCHKLINHQIFTNLILVFIMLSSVSLAAEDPIRNFSARNIILGYFDYAFTAIFTVEIL 940
Query: 382 --------YVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKM 537
YVF +FT E ++K+ A G H A+ RN +N+LD ++V + LVS +
Sbjct: 941 LKILGYADYVFTSMFTFEILIKMTAFGAFLHKGAFCRNYFNLLDLLVVGVSLVSFGIQSS 1000
Query: 538 SIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIG 717
+I VK LR RVLRPLR ++ L+ V+ + A+ + +I ++ + ++A IG
Sbjct: 1001 AIS--VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIG 1058
Query: 718 LELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMG-VRWECSSNTT 894
++LF GK + C D + S +C+ + L N G
Sbjct: 1059 VQLFKGKFYR-----------------CTDDAKSSPEECKGTYILYNNGDTAPPMVKERI 1101
Query: 895 WPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDA----VGREWPW-----IYFV 1047
W N NFDN +AM+ +F + EGW ++Y D+ +G + + I+F+
Sbjct: 1102 W---YNSDFNFDNVLMAMMALFTVSTFEGWPTLLYKAIDSNKENMGPIYNYRIEISIFFI 1158
Query: 1048 TLVILGSFFVLNLVLGVLSGEFSKEREK 1131
+I+ +FF++N+ +G + F ++ EK
Sbjct: 1159 IYIIIIAFFMMNIFVGFVIVTFQEQGEK 1186
Score = 92.0 bits (227), Expect = 1e-16
Identities = 66/274 (24%), Positives = 128/274 (46%), Gaps = 20/274 (7%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHY-----------------PSSRGFEDFL---DVFN 3459
V S F +++ +++ +NT+++A +HY P+ R +V N
Sbjct: 507 VKSVIFYWLVIILVFLNTLTIASEHYNQPDWLTEVQGGSCSDPPAHRTHSQAQRCSEVAN 566
Query: 3460 LIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINF 3639
+ +F E ++K+ +L + Y +N FD VV G ++ +L + + I+
Sbjct: 567 KVLLAMFTLEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGIVETILVEL--AIMSPLGISV 624
Query: 3640 FRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVAL 3819
FR R++R+ K+ + L+ + + S +++ + LL+ L I++++GMQ FG
Sbjct: 625 FRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFN 684
Query: 3820 DDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNE 3999
D T + + + F +FP A+L +F+ TGE W +M D P S
Sbjct: 685 FDET-VTKRSTFDNFPQALLTVFQILTGEDWNTVMY---DGIMAYGGPAS---------- 730
Query: 4000 SRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDN 4101
YFI F+ +++++N+F+A+ +DN
Sbjct: 731 ---SGMLVSIYFIILFICGNYILLNVFLAIAVDN 761
Score = 77.0 bits (188), Expect = 5e-12
Identities = 75/357 (21%), Positives = 135/357 (37%), Gaps = 60/357 (16%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP + +V FE+++ +I N + LAI S N ++ + VF VF
Sbjct: 1217 NPYQYKFWYVVNSTGFEYVMFILIILNTLCLAIQHH---GQSHLFNYAMDILNMVFTGVF 1273
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSK------------MSIQ 546
T+E +LK++A F P Y+ + WN+ D ++V+ +V ILS+ + +
Sbjct: 1274 TVEMILKLIA----FKPRGYVGDPWNVFDALVVIGSVVDIILSQNYFADAWNTFDALIVV 1329
Query: 547 G--------------------------------FDVKALRAFRVLRPLRLVSGVPSLQVV 630
G + R FRV+R ++L+S ++ +
Sbjct: 1330 GSVVDIAITEINSATIPVVKVIVDPGNTEDSARISITFFRLFRVMRLVKLLSRGEGIRTL 1389
Query: 631 LNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTD 810
L +++ L ++ALL+ + IYA+IG+++F G++A D T
Sbjct: 1390 LWTFIKSFQALPYVALLIAMLFFIYAVIGMQVF-------------GKIAMVDGTQI--- 1433
Query: 811 TEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTD 990
N NF F A+L +F+C + E W +
Sbjct: 1434 ---------------------------------NRNNNFQTFPQAVLMLFRCATGEAWQE 1460
Query: 991 VMY----------------WVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
+M G + YF++ +L +F ++NL + V+ F
Sbjct: 1461 IMLACLPGKLCDSESDYNPGEERTCGSGFAIFYFISFYMLCAFLIINLFVAVIMDNF 1517
Score = 73.9 bits (180), Expect = 4e-11
Identities = 74/313 (23%), Positives = 127/313 (39%), Gaps = 53/313 (16%)
Frame = +1
Query: 3466 FTGVFAFEAVLKIVA----LNPKNYISDRWNVFDLLVVVGSFIDITYGKL---------- 3603
F +F E LKI+A ++ +Y+ + WN+ D ++V+ + +
Sbjct: 156 FLIIFTIETFLKIIAYGLVMHQNSYVRNGWNLLDFVIVIIGLFSVALEMITKDADSSGQS 215
Query: 3604 --NPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFI 3777
PGG + R FRV+R ++L+S ++ +L + +K+ L ++ALL++ + I
Sbjct: 216 GGKPGG---FDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIII 272
Query: 3778 YAVIGMQFF-------------GKVALDDST---------------SIHR------NN-- 3849
YAVIG++ F G A ++ T +I R NN
Sbjct: 273 YAVIGLELFIGKMHATCYIKETGSFAEEEPTPCAVSGHGRHCLLNGTICREGWQGPNNGI 332
Query: 3850 -NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAY 4026
NF +F A+L +F+ T E W D++ +D G +
Sbjct: 333 TNFDNFLFAMLTVFQCITMEGWTDVLYWMND---------------------AMGFELPW 371
Query: 4027 PYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIK 4206
YF+S + SF V+NL + V+ F G + +R + + D KG
Sbjct: 372 VYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDF---QKLREKQQLEEDLKG--- 425
Query: 4207 HLDVVTLLRKISP 4245
+LD +T I P
Sbjct: 426 YLDWITQAEDIDP 438
Score = 73.6 bits (179), Expect = 5e-11
Identities = 79/316 (25%), Positives = 123/316 (38%), Gaps = 56/316 (17%)
Frame = +1
Query: 2281 SEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDP 2460
S+ ST P+A LF L+ N R C +V F +L I + LA P
Sbjct: 55 SKKQGGSTNSRPPRA--LFCLTLNNPVRRACISLVEWKPFDIFILLSIFANCVALAIYIP 112
Query: 2461 L---QANSTRNMILNY-----------------------FDYFFTSVFTVEITLKVIVFG 2562
+NST ++ +Y F +FT+E LK+I +G
Sbjct: 113 FPGDDSNSTNQELMKMTMEAGVVLRLVRGEPAVKSCGETVEYAFLIIFTIETFLKIIAYG 172
Query: 2563 LVFHKGSFCRNAFNLLDILVVAVSLTSFVLR---TDAMSX-----------XXXXXXXXX 2700
LV H+ S+ RN +NLLD ++V + L S L DA S
Sbjct: 173 LVMHQNSYVRNGWNLLDFVIVIIGLFSVALEMITKDADSSGQSGGKPGGFDVKALRAFRV 232
Query: 2701 XXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLS 2880
++ L+ V+ +I A+ + +I L+ + ++A+IG++LF G
Sbjct: 233 LRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAVIGLELFIG--------- 283
Query: 2881 KMTEAECRGEYIHYEDGDPTKPVSK-------------KRVW---SNNDFNFDNVGDAMI 3012
KM E + + +PT + W +N NFDN AM+
Sbjct: 284 KMHATCYIKETGSFAEEEPTPCAVSGHGRHCLLNGTICREGWQGPNNGITNFDNFLFAML 343
Query: 3013 SLFVVSTFEGWPQLLY 3060
++F T EGW +LY
Sbjct: 344 TVFQCITMEGWTDVLY 359
Score = 64.7 bits (156), Expect = 2e-08
Identities = 59/268 (22%), Positives = 102/268 (38%), Gaps = 55/268 (20%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+H+GQS ++ + N+ F +F++EM+LK+ + Y +N FD VVI S+++
Sbjct: 1250 QHHGQSHLFNYAMDILNMVFTGVFTVEMILKLIAFKPRGYVGDPWNVFDALVVIGSVVDI 1309
Query: 1657 VLVY---------FDLMKPLG----------------------------------VSVLR 1707
+L FD + +G ++ R
Sbjct: 1310 ILSQNYFADAWNTFDALIVVGSVVDIAITEINSATIPVVKVIVDPGNTEDSARISITFFR 1369
Query: 1708 SARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFN 1887
R++R+ K+ GMQVFG +
Sbjct: 1370 LFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQVFGKIAMVD 1429
Query: 1888 PQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIE----------SFGGVGTLGVIV 2037
Q NF TF QA+L +F+ TGE W +M + + G T G
Sbjct: 1430 GTQINRNNNFQTFPQAVLMLFRCATGEAWQEIMLACLPGKLCDSESDYNPGEERTCGSGF 1489
Query: 2038 CIYYIVLF--ICGNYILLNVFLAIAVDN 2115
I+Y + F +C ++++N+F+A+ +DN
Sbjct: 1490 AIFYFISFYMLCA-FLIINLFVAVIMDN 1516
Score = 63.5 bits (153), Expect = 6e-08
Identities = 84/384 (21%), Positives = 145/384 (36%), Gaps = 37/384 (9%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALA-----------------IYQPYPAQDS 348
N R+ C + V+ F +L++ ++ N + +A P +
Sbjct: 496 NRFCRRKCRAAVKSVIFYWLVIILVFLNTLTIASEHYNQPDWLTEVQGGSCSDPPAHRTH 555
Query: 349 DYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTIL 528
E V + +FT+E ++K+ ++G AY + +N D +V G+V TIL
Sbjct: 556 SQAQRCSEVANKVLLAMFTLEMLVKMYSLGLQ----AYFVSLFNRFDCFVVCGGIVETIL 611
Query: 529 SKMSIQG-FDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIY 705
+++I + R R+LR ++ SL ++ ++L +M IA L+L + L
Sbjct: 612 VELAIMSPLGISVFRCVRLLRIFKVTRHWASLSNLVASLLNSM---KSIASLLLLLFLFI 668
Query: 706 AIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSS 885
I L G G F +++T
Sbjct: 669 IIFSL--------------------------LGMQLFGGKFNFD--ETVTKR-------- 692
Query: 886 NTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMY-----WVNDAVGREWPWIYFVT 1050
+ FDNF A+LTVFQ ++ E W VMY + A IYF+
Sbjct: 693 -----------STFDNFPQALLTVFQILTGEDWNTVMYDGIMAYGGPASSGMLVSIYFII 741
Query: 1051 LVILGSFFVLNLVLGVLSGEFS---------KEREKARARGLFQKFREKQQLEEDLKGYL 1203
L I G++ +LN+ L + + KE E+A+ R K + E ++G
Sbjct: 742 LFICGNYILLNVFLAIAVDNLADAESLNTAQKEEEEAKKRRNSAKDVSPENKVEPVEGKE 801
Query: 1204 DWITQAED-----IEPVNEDEQED 1260
+ D +E DE+E+
Sbjct: 802 TKVLLMADKESPAVESAVSDEEEE 825
Score = 47.4 bits (111), Expect = 0.004
Identities = 48/234 (20%), Positives = 86/234 (36%), Gaps = 38/234 (16%)
Frame = +1
Query: 1522 ANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPL 1689
A+ F +F+ E+L+KM + G + + FN D VV S++ F + +
Sbjct: 947 ADYVFTSMFTFEILIKMTAFGAFLHKGAFCRNYFNLLDLLVVGVSLVSFGIQSSAISV-- 1004
Query: 1690 GVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFG 1869
V +LR R+LR + G+Q+F
Sbjct: 1005 -VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFK 1063
Query: 1870 GKF------------------------NFNPQQPKPRA------NFDTFVQALLTVFQIL 1959
GKF + P K R NFD + A++ +F +
Sbjct: 1064 GKFYRCTDDAKSSPEECKGTYILYNNGDTAPPMVKERIWYNSDFNFDNVLMAMMALFTVS 1123
Query: 1960 TGEDWNTVMYHGI----ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
T E W T++Y I E+ G + + + I++I+ I + ++N+F+ +
Sbjct: 1124 TFEGWPTLLYKAIDSNKENMGPIYNYRIEISIFFIIYIIIIAFFMMNIFVGFVI 1177
>gi|509344|emb|CAA81219.1| L-type Ca2+ channel isoform 1, neuronal
subform [Homo sapiens]
Length = 683
Score = 759 bits (1959), Expect = 0.0
Identities = 381/614 (62%), Positives = 475/614 (77%), Gaps = 31/614 (5%)
Frame = +1
Query: 2971 NNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXX 3150
N+ F+FDNV AM++LF VSTFEGWP+LLY +IDS+ EDKGPI+N R +++
Sbjct: 2 NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIII 61
Query: 3151 XXXXXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRV 3330
GFVIVTFQ +GE+EY+NCELDKNQR+C+E+ALKA+P RRYIP+N+ QY+V
Sbjct: 62 IAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKV 121
Query: 3331 WWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVA 3510
W+ V S FEY++F++I++NT+ LA +HY S F+ +++ N++FTG+F E +LK++A
Sbjct: 122 WYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA 181
Query: 3511 LNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGG------------TNLISINFFRLFR 3654
PK+Y D WN FD L+VVGS +DI ++NP + ISI FFRLFR
Sbjct: 182 FKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFR 241
Query: 3655 VMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTS 3834
VMRLVKLLSRGEGIRTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+AL+D+T
Sbjct: 242 VMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTE 301
Query: 3835 IHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGN 4014
I+RNNNF +FP A+L+LF+ ATGEAWQDIML+C + +C P S+ + E+ CG+
Sbjct: 302 INRNNNFQTFPQAVLLLFKCATGEAWQDIMLACMPGK--KCAPESEPSNSTE-GETPCGS 358
Query: 4015 NFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAK 4194
+FA YFISF+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+W+EYDP+AK
Sbjct: 359 SFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAK 418
Query: 4195 GRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTN 4374
GRIKHLDVVTLLR+I PPLGFGKLCPHR+ACKRLVSMNMPLNSDGTV FNATLFALVRT
Sbjct: 419 GRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTA 478
Query: 4375 LKIYTE-------------------GNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGK 4497
L+I TE GN+++ANE+LR+ IK+IWKRT LLD+VVPPAG
Sbjct: 479 LRIKTEEGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAG- 537
Query: 4498 EDDVTVGKFYATFLIQDYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKR 4677
+D+VTVGKFYATFLIQ+YFR+FKKRKE G P+Q A++LQAGLRTLH+IGPE++R
Sbjct: 538 DDEVTVGKFYATFLIQEYFRKFKKRKEQGLVG-KPSQR-NALSLQAGLRTLHDIGPEIRR 595
Query: 4678 AISGNLETDFNFDE 4719
AISG+L + D+
Sbjct: 596 AISGDLTAEEELDK 609
Score = 82.8 bits (203), Expect = 9e-14
Identities = 73/315 (23%), Positives = 130/315 (41%), Gaps = 33/315 (10%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+L+ +I N I LA+ Q Y Q +K + + +F +FT+E +LK++A F
Sbjct: 130 FEYLMFVLILLNTICLAM-QHY-GQSCLFK-IAMNILNMLFTGLFTVEMILKLIA----F 182
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMSI---------------QGFDVKALRAFRV 582
P Y +AWN D +IVV +V +++++ + R FRV
Sbjct: 183 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRV 242
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDP 762
+R ++L+S ++ +L +++ L ++ALL++ + IYA+IG+++F
Sbjct: 243 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF----------- 291
Query: 763 ATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGL 942
G++A D T N NF F
Sbjct: 292 --GKIALNDTTEI------------------------------------NRNNNFQTFPQ 313
Query: 943 AMLTVFQCVSLEGWTDVMYWV------------------NDAVGREWPWIYFVTLVILGS 1068
A+L +F+C + E W D+M G + YF++ +L +
Sbjct: 314 AVLLLFKCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCA 373
Query: 1069 FFVLNLVLGVLSGEF 1113
F ++NL + V+ F
Sbjct: 374 FLIINLFVAVIMDNF 388
Score = 69.7 bits (169), Expect = 8e-10
Identities = 55/240 (22%), Positives = 96/240 (39%), Gaps = 27/240 (11%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HYGQS + N+ F LF++EM+LK+ + Y +N FD +V+ SI++
Sbjct: 148 QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDI 207
Query: 1657 VLVYFDLMKP--------------LGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXX 1794
+ + + + ++ R R++R+ K+
Sbjct: 208 AITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQ 267
Query: 1795 XXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDW 1974
GMQVFG + + NF TF QA+L +F+ TGE W
Sbjct: 268 ALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFKCATGEAW 327
Query: 1975 NTVMYHGI-------ESFGGVGTLGVIVC------IYYIVLFICGNYILLNVFLAIAVDN 2115
+M + ES T G C Y+I ++ ++++N+F+A+ +DN
Sbjct: 328 QDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDN 387
Score = 53.5 bits (127), Expect = 6e-05
Identities = 58/258 (22%), Positives = 112/258 (42%), Gaps = 17/258 (6%)
Frame = +1
Query: 2335 FILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMILNYFDYFF 2514
+I + + ++V+ VVN +YF + IL+++ LA + Q+ + + +N + F
Sbjct: 111 YIPKNQHQYKVW--YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFK-IAMNILNMLF 167
Query: 2515 TSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLR----------TDA 2664
T +FTVE+ LK+I F K FC +A+N D L+V S+ + + +
Sbjct: 168 TGLFTVEMILKLIAFK---PKHYFC-DAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPS 223
Query: 2665 MSXXXXXXXXXXXXXXXAI-------NRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
M+ + +R +G++ ++ I + + + + L+ ML F++
Sbjct: 224 MNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIY 283
Query: 2824 AIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGD 3003
A+IG+Q+F G L ND +++ N + NF
Sbjct: 284 AVIGMQVF-GKIAL-NDTTEI----------------------------NRNNNFQTFPQ 313
Query: 3004 AMISLFVVSTFEGWPQLL 3057
A++ LF +T E W ++
Sbjct: 314 AVLLLFKCATGEAWQDIM 331
Score = 38.9 bits (89), Expect = 1.5
Identities = 22/83 (26%), Positives = 43/83 (51%), Gaps = 9/83 (10%)
Frame = +1
Query: 910 NGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIY---------FVTLVIL 1062
N +FDN AM+ +F + EGW +++Y D+ + IY F+ +I+
Sbjct: 2 NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIII 61
Query: 1063 GSFFVLNLVLGVLSGEFSKEREK 1131
+FF++N+ +G + F ++ E+
Sbjct: 62 IAFFMMNIFVGFVIVTFQEQGEQ 84
Score = 38.5 bits (88), Expect = 1.9
Identities = 17/70 (24%), Positives = 37/70 (52%), Gaps = 4/70 (5%)
Frame = +1
Query: 1912 NFDTFVQALLTVFQILTGEDWNTVMYHGIESF----GGVGTLGVIVCIYYIVLFICGNYI 2079
+FD + A++ +F + T E W ++Y I+S G + V + I++I+ I +
Sbjct: 6 DFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFF 65
Query: 2080 LLNVFLAIAV 2109
++N+F+ +
Sbjct: 66 MMNIFVGFVI 75
>gi|22204436|emb|CAD43424.1| SI:dZ136D19.3 (novel protein similar to
human voltage-gated L-type calcium channel subunit (Isl))
[Danio rerio]
Length = 810
Score = 735 bits (1897), Expect = 0.0
Identities = 368/580 (63%), Positives = 443/580 (75%), Gaps = 29/580 (5%)
Frame = +1
Query: 3052 LLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIVTFQNEGEREYEN 3231
LLY AIDSN E+ GPI+N R +++ GFVIVTFQ +GE+EY+N
Sbjct: 1 LLYKAIDSNRENMGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEKEYKN 60
Query: 3232 CELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACK 3411
CELDKNQR+C+E+ALKA+P RRYIP+N QY+ W+ V S FEY++F++I++NT+ LA +
Sbjct: 61 CELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSTGFEYIMFVLILLNTICLAVQ 120
Query: 3412 HYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDIT 3591
HY S F +D+ N++FT VF E VLK++A P+ Y D WNVFD LVV+GS +DI
Sbjct: 121 HYGQSELFNYVMDILNMVFTAVFTVEMVLKLIAFKPRGYFGDAWNVFDALVVIGSIVDIV 180
Query: 3592 YGKL-----------------------------NPGGTNLISINFFRLFRVMRLVKLLSR 3684
++ N + ISI FFRLFRVMRLVKLLSR
Sbjct: 181 LSEIDHYFTDAWNTFDALIVVGSVVDIAITEVNNTEDSARISITFFRLFRVMRLVKLLSR 240
Query: 3685 GEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSF 3864
GEGIRTLLWTF+KSFQALPYVALLI +LFFIYAVIGMQ FGK+A+ D T I+RNNNF +F
Sbjct: 241 GEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQVFGKIAMVDHTQINRNNNFQTF 300
Query: 3865 PAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISF 4044
P A+L+LFR ATGEAWQ+IML+C + CDP SD Y+ G E CG++FA YFI+F
Sbjct: 301 PQAVLLLFRCATGEAWQEIMLACMPGK--LCDPESD-YNPG--EEMTCGSSFAIIYFITF 355
Query: 4045 FMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVT 4224
+MLC+FL+INLFVAVIMDNFDYLTRDWSILGPHHL+EF R+WSEYDP+AKGRIKHLDVVT
Sbjct: 356 YMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVT 415
Query: 4225 LLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNID 4404
LLR+I PPLGFGKLCPHR+ACKRLV+MNMPLNSDGTV FNATLFALVRT LKI TEGN++
Sbjct: 416 LLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLE 475
Query: 4405 EANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEME 4584
+ANE+LR+ IK+IWKRT LLD+VVPPAG +D+VTVGKFYATFLIQDYFR+FKKRKE
Sbjct: 476 QANEELRAVIKKIWKRTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQDYFRKFKKRKEEG 534
Query: 4585 AKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETD 4704
GV PAQ A+ALQAGLRTLH+IGPE++RAIS +L+ D
Sbjct: 535 LVGVHPAQNNTAIALQAGLRTLHDIGPEIRRAISCDLQDD 574
Score = 92.4 bits (228), Expect = 1e-16
Identities = 81/345 (23%), Positives = 142/345 (40%), Gaps = 48/345 (13%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP + +V FE+++ +I N I LA+ Q Y S+ N +++ + VF VF
Sbjct: 87 NPYQYKFWYVVNSTGFEYIMFVLILLNTICLAV-QHYG--QSELFNYVMDILNMVFTAVF 143
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD--------- 555
T+E VLK++A F P Y +AWN+ D ++V+ +V +LS++ D
Sbjct: 144 TVEMVLKLIA----FKPRGYFGDAWNVFDALVVIGSIVDIVLSEIDHYFTDAWNTFDALI 199
Query: 556 -----------------------VKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLL 666
+ R FRV+R ++L+S ++ +L +++ L
Sbjct: 200 VVGSVVDIAITEVNNTEDSARISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALP 259
Query: 667 HIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSD 846
++ALL+ + IYA+IG+++F G++A D T
Sbjct: 260 YVALLIAMLFFIYAVIGMQVF-------------GKIAMVDHTQI--------------- 291
Query: 847 SLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVM---------- 996
N NF F A+L +F+C + E W ++M
Sbjct: 292 ---------------------NRNNNFQTFPQAVLLLFRCATGEAWQEIMLACMPGKLCD 330
Query: 997 ----YWVNDAV--GREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
Y + + G + IYF+T +L +F ++NL + V+ F
Sbjct: 331 PESDYNPGEEMTCGSSFAIIYFITFYMLCAFLIINLFVAVIMDNF 375
Score = 73.9 bits (180), Expect = 4e-11
Identities = 64/255 (25%), Positives = 103/255 (40%), Gaps = 42/255 (16%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HYGQSE ++ + N+ F +F++EM+LK+ + Y +N FD VVI SI++
Sbjct: 120 QHYGQSELFNYVMDILNMVFTAVFTVEMVLKLIAFKPRGYFGDAWNVFDALVVIGSIVDI 179
Query: 1657 VLVY-----------FDLMKPLG--------------------VSVLRSARLLRIFKVTK 1743
VL FD + +G ++ R R++R+ K+
Sbjct: 180 VLSEIDHYFTDAWNTFDALIVVGSVVDIAITEVNNTEDSARISITFFRLFRVMRLVKLLS 239
Query: 1744 YWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDT 1923
GMQVFG + Q NF T
Sbjct: 240 RGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQVFGKIAMVDHTQINRNNNFQT 299
Query: 1924 FVQALLTVFQILTGEDWNTVMYHGI-------ESFGGVG---TLG-VIVCIYYIVLFICG 2070
F QA+L +F+ TGE W +M + ES G T G IY+I ++
Sbjct: 300 FPQAVLLLFRCATGEAWQEIMLACMPGKLCDPESDYNPGEEMTCGSSFAIIYFITFYMLC 359
Query: 2071 NYILLNVFLAIAVDN 2115
++++N+F+A+ +DN
Sbjct: 360 AFLIINLFVAVIMDN 374
Score = 47.4 bits (111), Expect = 0.004
Identities = 47/190 (24%), Positives = 84/190 (43%), Gaps = 34/190 (17%)
Frame = +1
Query: 2380 VVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVF 2559
VVN + F + IL+++ LA + Q+ N +++ + FT+VFTVE+ LK+I F
Sbjct: 96 VVNSTGFEYIMFVLILLNTICLAVQHYGQSELF-NYVMDILNMVFTAVFTVEMVLKLIAF 154
Query: 2560 GLVFHKGSFCRNAFNLLDILVVAVSLTSFVLR------TDAMSXXXXXXXXXXXXXXXA- 2718
+G F +A+N+ D LVV S+ VL TDA +
Sbjct: 155 K---PRGYF-GDAWNVFDALVVIGSIVDIVLSEIDHYFTDAWNTFDALIVVGSVVDIAIT 210
Query: 2719 ---------------------------INRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQF 2817
++R +G++ ++ I + + + + L+ ML F
Sbjct: 211 EVNNTEDSARISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFF 270
Query: 2818 MFAIIGVQLF 2847
++A+IG+Q+F
Sbjct: 271 IYAVIGMQVF 280
>gi|7209876|dbj|BAA13136.2| voltage-dependent calcium channel [Loligo
bleekeri]
Length = 2196
Score = 697 bits (1798), Expect = 0.0
Identities = 358/771 (46%), Positives = 495/771 (63%), Gaps = 9/771 (1%)
Frame = +1
Query: 2281 SEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDP 2460
SE PA KP+ SS+FI TN R FC+ VVN YF ++ I SS LAAEDP
Sbjct: 858 SEEPAFGGPKPMLPYSSMFIFGPTNPVRRFCHFVVNLRYFDLFIMIVICASSIALAAEDP 917
Query: 2461 LQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLT 2640
+ S N ILNYFDY FT VFT+E+ LK++ G++ H GS+CR+A+N+LD VV +L
Sbjct: 918 VNDESVNNQILNYFDYVFTGVFTIEMLLKIVDLGIILHPGSYCRDAWNILDATVVICALV 977
Query: 2641 SFVLRTDA---MSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFML 2811
+F A ++ INR LK V CV+ ++K + NI++V +
Sbjct: 978 AFAFGDAAGGNLNTIKSLRVLRVLRPLKTINRIPKLKAVFDCVVNSLKNVSNILIVYLLF 1037
Query: 2812 QFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFD 2991
QF+FA+I VQLFKG FF C D+SK EC+G+Y YED + KP K R W DF++D
Sbjct: 1038 QFIFAVIAVQLFKGKFFYCTDMSKSNREECQGQYFDYED-ESDKPRVKNREWLRQDFHYD 1096
Query: 2992 NVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXX 3171
NV AM++LF V+T EGWP +L ++DS +D GP R +A+
Sbjct: 1097 NVMFAMLTLFTVTTGEGWPMVLKNSMDSTSDDMGPKPGYRMEMAIYYVVFFIVFPFFFVN 1156
Query: 3172 XXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVT 3345
+I+TFQ +GE E + +LDKNQ++CIEF+++AKP RY+P+N+ ++Y++W V
Sbjct: 1157 IFVALIIITFQEQGENELVDQDLDKNQKQCIEFSIEAKPSCRYVPKNKNSIKYKIWQVVV 1216
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FE V+ ++I +NT+ L K+Y S ++ L NL F+ +F E +LK++ N
Sbjct: 1217 SPKFECVVMVLIALNTLVLMMKYYGSPTEYKLLLQNLNLAFSVLFTIECILKLMGFGIGN 1276
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTL 3705
Y DRWN+FD ++V+GS ID+ + P ++ + FRLFR RLVKLL +G IR L
Sbjct: 1277 YFRDRWNMFDFIIVIGSIIDVVTTNVLPSASSFRT-GSFRLFRAARLVKLLRQGYTIRLL 1335
Query: 3706 LWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVL 3885
LWTF++SF+ALPYV LLI +LFFIYA+IGMQ FG + LD TSI+R+NNF SF A+L+L
Sbjct: 1336 LWTFLQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIRLDSKTSINRHNNFRSFFYAVLLL 1395
Query: 3886 FRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFL 4065
FR ATGE+WQ IMLSC CDP S + ++ CG + AY YF++F LCSFL
Sbjct: 1396 FRCATGESWQQIMLSCLSGRP--CDPESK------MLDNSCGLDIAYIYFVTFIFLCSFL 1447
Query: 4066 VINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
++NLFVAVIMDNFDYLTRD SILGPHHL+E+ R+W+EYDP A GR+ + D+ +LR++ P
Sbjct: 1448 MLNLFVAVIMDNFDYLTRDTSILGPHHLDEYSRVWAEYDPLASGRVHYTDMYEMLRRMEP 1507
Query: 4246 PLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEG--NIDEANEQ 4419
P+GFG+ CP+RLAC++L+ MNMPL DGTV F+ TLFALVR +L I +D+ +E+
Sbjct: 1508 PVGFGRNCPYRLACRKLIRMNMPLKEDGTVHFSTTLFALVRESLSIRMSSAEEMDKKDEE 1567
Query: 4420 LRSAIKRIWKRTHKDLLDEVVPPAGKEDD--VTVGKFYATFLIQDYFRRFK 4566
+R IKR+W K ++D +VPP + ++ +TVGK Y LI + +R +K
Sbjct: 1568 MREVIKRVWPVQGKKIVDLLVPPNHELNNGKLTVGKVYGGLLIAENWRAYK 1618
Score = 521 bits (1342), Expect = e-146
Identities = 292/688 (42%), Positives = 386/688 (55%), Gaps = 47/688 (6%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
N IRK I+EW PFE+++L I ANCI LA+ + P +D LE E+ F+ +F
Sbjct: 52 NFIRKYAKIIIEWGPFEYMVLLTIIANCIVLALEEHLPNEDKTPLAVQLEATEFYFLGIF 111
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
+E +LKIVA+GF H +YLRN WNI+DF++VV G +S + S FD++ LRA RV
Sbjct: 112 CVEALLKIVALGFALHKGSYLRNVWNIMDFVVVVTGFISIFPASNS---FDLRTLRAVRV 168
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI-- 756
LRPL+LVSG+PSLQVVL +I+RAM PLL + LLVLF I+I+AIIGLE + G H C
Sbjct: 169 LRPLKLVSGIPSLQVVLKSIIRAMAPLLQVCLLVLFAIVIFAIIGLEFYTGAFHKACFIK 228
Query: 757 --DPATGQLAQKDPT---PCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGIT 921
D + + D PC EGS + C+ + + +C N W GPN GIT
Sbjct: 229 PNDDSEDNIEYGDEDTIRPCAN--EGSGYHCRANIA--------KCRFN--WAGPNYGIT 276
Query: 922 NFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVL 1101
+FDN G AMLTVFQCV++EGWT V+Y+ +DAVG + WIYFV L++LGSFF+LNLVLGVL
Sbjct: 277 SFDNMGFAMLTVFQCVTMEGWTQVLYYTDDAVGDAYNWIYFVPLIVLGSFFMLNLVLGVL 336
Query: 1102 SGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVAQTX 1281
SGEF+KERE+ R F K R +QQ+E +L GYL+WI +AE++ ++E+ ++D+
Sbjct: 337 SGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWICKAEEV-ILDEERKKDDGTISDE 395
Query: 1282 XXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLV----------------- 1410
++ +MK ++L L+
Sbjct: 396 DKLRIIEGALGFNARRLAAQKVKKMKENKELTIGDEDNDGDLLSGINVGGSFGRGLKNRK 455
Query: 1411 -----------------------KSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTM 1521
K+Q FYW SEHYGQ+EW F +
Sbjct: 456 AHGRCAGFWRAEKHLRFTIRKCVKTQGFYWFVIILVFLNTLCVASEHYGQAEWHTEFLYV 515
Query: 1522 ANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSV 1701
F+ LF EML+KMY LG Y S FN FDC V++ SI+E + G+S
Sbjct: 516 MEFAFLALFMSEMLIKMYGLGVRLYFQSSFNIFDCVVILVSIIEVIWSAIKDGSSFGIST 575
Query: 1702 LRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFN 1881
LR+ RLLR+FKVT+YW+ GMQ+FGG N
Sbjct: 576 LRALRLLRMFKVTRYWSSLRNLVVSLLSSMRSIVSLLFLLFLFILIFALLGMQLFGGMMN 635
Query: 1882 FNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLF 2061
F ++ +P +FDTF ALLTVFQILTGEDWN VMY GI + GG+ G++ C Y+I+L
Sbjct: 636 F--EEGRPPGHFDTFPIALLTVFQILTGEDWNEVMYSGIRARGGIAGGGMLYCSYFIILV 693
Query: 2062 ICGNYILLNVFLAIAVDNLADADSLTNA 2145
+ GNY LLNVFLAIAVDNLA+A LT A
Sbjct: 694 LFGNYTLLNVFLAIAVDNLANAQELTAA 721
Score = 142 bits (357), Expect = 1e-31
Identities = 96/312 (30%), Positives = 159/312 (50%), Gaps = 10/312 (3%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+R+ C +V + F+ I+ +ICA+ IALA P D N +L +YVF VF
Sbjct: 882 NPVRRFCHFVVNLRYFDLFIMIVICASSIALAAEDP--VNDESVNNQILNYFDYVFTGVF 939
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD-VKALRAFR 579
TIE +LKIV +G + HP +Y R+AWNILD +V+ LV+ + + +K+LR R
Sbjct: 940 TIEMLLKIVDLGIILHPGSYCRDAWNILDATVVICALVAFAFGDAAGGNLNTIKSLRVLR 999
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+ ++ +P L+ V + ++ ++ + +I ++ L I+A+I ++LF GK C D
Sbjct: 1000 VLRPLKTINRIPKLKAVFDCVVNSLKNVSNILIVYLLFQFIFAVIAVQLFKGKFF-YCTD 1058
Query: 760 PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFG 939
+++ + C +G F + + N W + ++DN
Sbjct: 1059 -----MSKSNREEC----QGQYFDYEDESDKPRV-------KNREWLRQD---FHYDNVM 1099
Query: 940 LAMLTVFQCVSLEGWTDV----MYWVNDAVG-----REWPWIYFVTLVILGSFFVLNLVL 1092
AMLT+F + EGW V M +D +G R IY+V I+ FF +N+ +
Sbjct: 1100 FAMLTLFTVTTGEGWPMVLKNSMDSTSDDMGPKPGYRMEMAIYYVVFFIVFPFFFVNIFV 1159
Query: 1093 GVLSGEFSKERE 1128
++ F ++ E
Sbjct: 1160 ALIIITFQEQGE 1171
Score = 114 bits (285), Expect = 3e-23
Identities = 70/284 (24%), Positives = 142/284 (49%), Gaps = 1/284 (0%)
Frame = +1
Query: 3316 LQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAV 3495
L++ + V ++ F + + +++ +NT+ +A +HY + +FL V F +F E +
Sbjct: 470 LRFTIRKCVKTQGFYWFVIILVFLNTLCVASEHYGQAEWHTEFLYVMEFAFLALFMSEML 529
Query: 3496 LKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKL 3675
+K+ L + Y +N+FD +V++ S I++ + + G + I+ R R++R+ K+
Sbjct: 530 IKMYGLGVRLYFQSSFNIFDCVVILVSIIEVIWSAIKDGSS--FGISTLRALRLLRMFKV 587
Query: 3676 LSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNF 3855
+R L+ + + S +++ + L+ L I+A++GMQ FG + + +F
Sbjct: 588 TRYWSSLRNLVVSLLSSMRSIVSLLFLLFLFILIFALLGMQLFG--GMMNFEEGRPPGHF 645
Query: 3856 HSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAY-PY 4032
+FP A+L +F+ TGE W ++M S +R +GG+ G Y Y
Sbjct: 646 DTFPIALLTVFQILTGEDWNEVMYS-----GIRA--------RGGI----AGGGMLYCSY 688
Query: 4033 FISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVR 4164
FI + ++ ++N+F+A+ +DN L + ++E VR
Sbjct: 689 FIILVLFGNYTLLNVFLAIAVDN---LANAQELTAAEEIQEGVR 729
Score = 103 bits (256), Expect = 6e-20
Identities = 80/312 (25%), Positives = 141/312 (44%), Gaps = 15/312 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
N I+ +V FE +++ +I N + L + Y ++YK LL+ + F V+F
Sbjct: 1205 NSIKYKIWQVVVSPKFECVVMVLIALNTLVLMM--KYYGSPTEYK-LLLQNLNLAFSVLF 1261
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKM--SIQGFDVKALRAF 576
TIEC+LK++ G Y R+ WN+ DFIIV+ ++ + + + S F + R F
Sbjct: 1262 TIECILKLMGFGI----GNYFRDRWNMFDFIIVIGSIIDVVTTNVLPSASSFRTGSFRLF 1317
Query: 577 RVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI 756
R R ++L+ +++++L L++ L ++ LL+ + IYAIIG+++F G +
Sbjct: 1318 RAARLVKLLRQGYTIRLLLWTFLQSFKALPYVCLLIAMLFFIYAIIGMQVF-GNIR---- 1372
Query: 757 DPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNF 936
DS T++ N NF +F
Sbjct: 1373 ----------------------------LDSKTSI----------------NRHNNFRSF 1388
Query: 937 GLAMLTVFQCVSLEGWTDVMY-------------WVNDAVGREWPWIYFVTLVILGSFFV 1077
A+L +F+C + E W +M ++++ G + +IYFVT + L SF +
Sbjct: 1389 FYAVLLLFRCATGESWQQIMLSCLSGRPCDPESKMLDNSCGLDIAYIYFVTFIFLCSFLM 1448
Query: 1078 LNLVLGVLSGEF 1113
LNL + V+ F
Sbjct: 1449 LNLFVAVIMDNF 1460
Score = 102 bits (255), Expect = 8e-20
Identities = 70/268 (26%), Positives = 126/268 (46%), Gaps = 19/268 (7%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAED--PLQANSTRNMILNYF 2502
SLFI S N R + +++ F VL I+ + +LA E+ P + + + L
Sbjct: 44 SLFIFSEENFIRKYAKIIIEWGPFEYMVLLTIIANCIVLALEEHLPNEDKTPLAVQLEAT 103
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXX 2682
+++F +F VE LK++ G HKGS+ RN +N++D +VV S +++
Sbjct: 104 EFYFLGIFCVEALLKIVALGFALHKGSYLRNVWNIMDFVVVVTGFISIFPASNSFD-LRT 162
Query: 2683 XXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFF 2862
++ L+ V++ +I A+ + + L+ +FAIIG++ + G F
Sbjct: 163 LRAVRVLRPLKLVSGIPSLQVVLKSIIRAMAPLLQVCLLVLFAIVIFAIIGLEFYTGAFH 222
Query: 2863 LCNDLSKMTEAECRGEYIHYEDGDPTKP-------------VSKKRV-WSNNDF---NFD 2991
+ ++E + I Y D D +P ++K R W+ ++ +FD
Sbjct: 223 KACFIKPNDDSE---DNIEYGDEDTIRPCANEGSGYHCRANIAKCRFNWAGPNYGITSFD 279
Query: 2992 NVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
N+G AM+++F T EGW Q+LY D+
Sbjct: 280 NMGFAMLTVFQCVTMEGWTQVLYYTDDA 307
Score = 88.2 bits (217), Expect = 2e-15
Identities = 71/322 (22%), Positives = 144/322 (44%), Gaps = 8/322 (2%)
Frame = +1
Query: 253 VEWKPFEFLILFMICAN--CIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKI 426
V+ + F + ++ ++ N C+A Y +++ L +E+ F+ +F E ++K+
Sbjct: 478 VKTQGFYWFVIILVFLNTLCVASEHYG-----QAEWHTEFLYVMEFAFLALFMSEMLIKM 532
Query: 427 VAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSI-QGFDVKALRAFRVLRPLRLV 603
+G Y ++++NI D +++++ ++ I S + F + LRA R+LR ++
Sbjct: 533 YGLGVRL----YFQSSFNIFDCVVILVSIIEVIWSAIKDGSSFGISTLRALRLLRMFKVT 588
Query: 604 SGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ 783
SL+ ++ ++L +M ++ + L+ ILI+A++G++LF G +
Sbjct: 589 RYWSSLRNLVVSLLSSMRSIVSLLFLLFLFILIFALLGMQLF------------GGMMNF 636
Query: 784 KDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQ 963
++ P G +FD F +A+LTVFQ
Sbjct: 637 EEGRPPG---------------------------------------HFDTFPIALLTVFQ 657
Query: 964 CVSLEGWTDVMY-----WVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKERE 1128
++ E W +VMY A G YF+ LV+ G++ +LN+ L + + +E
Sbjct: 658 ILTGEDWNEVMYSGIRARGGIAGGGMLYCSYFIILVLFGNYTLLNVFLAIAVDNLANAQE 717
Query: 1129 KARARGLFQKFREKQQLEEDLK 1194
A + + R++Q+ E K
Sbjct: 718 LTAAEEIQEGVRQEQEAAEKKK 739
Score = 80.5 bits (197), Expect = 4e-13
Identities = 71/259 (27%), Positives = 119/259 (45%), Gaps = 9/259 (3%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY++ L I+ N + LA + H P+ L+ F G+F EA+LKIVAL
Sbjct: 67 FEYMVLLTIIANCIVLALEEHLPNEDKTPLAVQLEATEFYFLGIFCVEALLKIVALGFAL 126
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WN+ D +VVV FI I +N + R RV+R +KL+S
Sbjct: 127 HKGSYLRNVWNIMDFVVVVTGFISIF------PASNSFDLRTLRAVRVLRPLKLVSGIPS 180
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAA 3873
++ +L + +++ L V LL++ I+A+IG++F+ FH
Sbjct: 181 LQVVLKSIIRAMAPLLQVCLLVLFAIVIFAIIGLEFY-------------TGAFHK---- 223
Query: 3874 ILVLFRSATGEAWQDIMLSCSDREDVR-CDPMSDDYHKGGLNESRCGNNFAYP-YFISFF 4047
F ++ +I D + +R C YH N ++C N+A P Y I+ F
Sbjct: 224 --ACFIKPNDDSEDNI--EYGDEDTIRPCANEGSGYHCRA-NIAKCRFNWAGPNYGITSF 278
Query: 4048 MLCSFLVINLFVAVIMDNF 4104
F ++ +F V M+ +
Sbjct: 279 DNMGFAMLTVFQCVTMEGW 297
Score = 65.5 bits (158), Expect = 1e-08
Identities = 52/207 (25%), Positives = 85/207 (40%), Gaps = 10/207 (4%)
Frame = +1
Query: 1525 NLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLV-YFDLMKPLGVSV 1701
NL F +LF++E +LK+ G Y ++N FD +VI SI++ V
Sbjct: 1254 NLAFSVLFTIECILKLMGFGIGNYFRDRWNMFDFIIVIGSIIDVVTTNVLPSASSFRTGS 1313
Query: 1702 LRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFN 1881
R R R+ K+ + GMQVFG
Sbjct: 1314 FRLFRAARLVKLLRQGYTIRLLLWTFLQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIRL 1373
Query: 1882 FNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGI-------ESFGGVGTLGVIVC 2040
+ NF +F A+L +F+ TGE W +M + ES + G+ +
Sbjct: 1374 DSKTSINRHNNFRSFFYAVLLLFRCATGESWQQIMLSCLSGRPCDPESKMLDNSCGLDIA 1433
Query: 2041 IYYIV--LFICGNYILLNVFLAIAVDN 2115
Y V +F+C ++++LN+F+A+ +DN
Sbjct: 1434 YIYFVTFIFLC-SFLMLNLFVAVIMDN 1459
Score = 51.6 bits (122), Expect = 2e-04
Identities = 51/229 (22%), Positives = 86/229 (37%), Gaps = 37/229 (16%)
Frame = +1
Query: 1534 FVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSV 1701
F +F++EMLLK+ LG +Y +N D VVI +++ F +
Sbjct: 935 FTGVFTIEMLLKIVDLGIILHPGSYCRDAWNILDATVVICALVAFAFGDAAGGNLNTIKS 994
Query: 1702 LRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF- 1878
LR R+LR K +Q+F GKF
Sbjct: 995 LRVLRVLRPLKTINRIPKLKAVFDCVVNSLKNVSNILIVYLLFQFIFAVIAVQLFKGKFF 1054
Query: 1879 ------------------NFNPQQPKPRA----------NFDTFVQALLTVFQILTGEDW 1974
++ + KPR ++D + A+LT+F + TGE W
Sbjct: 1055 YCTDMSKSNREECQGQYFDYEDESDKPRVKNREWLRQDFHYDNVMFAMLTLFTVTTGEGW 1114
Query: 1975 NTVMYHGIES----FGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
V+ + ++S G + + IYY+V FI + +N+F+A+ +
Sbjct: 1115 PMVLKNSMDSTSDDMGPKPGYRMEMAIYYVVFFIVFPFFFVNIFVALII 1163
Score = 48.9 bits (115), Expect = 0.001
Identities = 43/223 (19%), Positives = 99/223 (44%), Gaps = 3/223 (1%)
Frame = +1
Query: 2410 VLFCILVSSAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFC 2589
V+ + +++ +A+E QA L ++ F ++F E+ +K+ G+ +
Sbjct: 487 VIILVFLNTLCVASEHYGQAE-WHTEFLYVMEFAFLALFMSEMLIKMYGLGVRL----YF 541
Query: 2590 RNAFNLLDILVVAVSLTSFVLRT--DAMSXXXXXXXXXXXXXXXAINRA-KGLKHVVQCV 2760
+++FN+ D +V+ VS+ + D S + R L+++V +
Sbjct: 542 QSSFNIFDCVVILVSIIEVIWSAIKDGSSFGISTLRALRLLRMFKVTRYWSSLRNLVVSL 601
Query: 2761 IVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPT 2940
+ ++++I +++ + F+ +FA++G+QLF G +++E+G P
Sbjct: 602 LSSMRSIVSLLFLLFLFILIFALLGMQLF-------------------GGMMNFEEGRPP 642
Query: 2941 KPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAI 3069
+FD A++++F + T E W +++Y I
Sbjct: 643 G-------------HFDTFPIALLTVFQILTGEDWNEVMYSGI 672
>gi|7447633|pir||JC5280 voltage-dependent calcium channel alpha 1
chain - Bleeker's squid
Length = 2206
Score = 693 bits (1789), Expect = 0.0
Identities = 356/771 (46%), Positives = 494/771 (63%), Gaps = 9/771 (1%)
Frame = +1
Query: 2281 SEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDP 2460
SE PA KP+ +S+FI TN R FC+ VVN YF ++ I SS LAAEDP
Sbjct: 868 SEEPAFGGPKPMLPYTSMFIFGPTNPVRRFCHFVVNLRYFDLFIMIVICASSIALAAEDP 927
Query: 2461 LQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLT 2640
+ S N ILNYFDY FT VFT+E+ LK++ G++ H GS+CR+A+N+LD VV +L
Sbjct: 928 VNDESVNNQILNYFDYVFTGVFTIEMLLKIVDLGIILHPGSYCRDAWNILDATVVICALV 987
Query: 2641 SFVLRTDA---MSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFML 2811
+F A ++ INR LK V CV+ ++K + NI++V +
Sbjct: 988 AFAFGDAAGGNLNTIKSLRVLRVLRPLKTINRIPKLKAVFDCVVNSLKNVSNILIVYLLF 1047
Query: 2812 QFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFD 2991
QF+FA+I VQLFKG FF C D+SK EC+G+Y YED + KP K R W DF++D
Sbjct: 1048 QFIFAVIAVQLFKGKFFYCTDMSKSNREECQGQYFDYED-ESDKPRVKNREWLRQDFHYD 1106
Query: 2992 NVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXX 3171
NV AM++LF V+T EGWP +L ++DS +D GP R +A+
Sbjct: 1107 NVMFAMLTLFTVTTGEGWPMVLKNSMDSTSDDMGPKPGYRMEMAIYYVVFFIVFPFFFVN 1166
Query: 3172 XXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVT 3345
+I+TFQ +GE E + +LDKNQ++CIEF+++AKP RY+P+N+ ++Y++W V
Sbjct: 1167 IFVALIIITFQEQGENELVDQDLDKNQKQCIEFSIEAKPSCRYVPKNKNSIKYKIWQVVV 1226
Query: 3346 SRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKN 3525
S FE V+ ++I +NT+ L K+Y S ++ L NL F+ +F E +LK++ N
Sbjct: 1227 SPKFECVVMVLIALNTLVLMMKYYGSPTEYKLLLQNLNLAFSVLFTIECILKLMGFGIGN 1286
Query: 3526 YISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTL 3705
Y DRWN+FD ++V+GS ID+ + P ++ + FRLFR RLVKLL +G IR L
Sbjct: 1287 YFRDRWNMFDFIIVIGSIIDVVTTNVLPSASSFRT-GSFRLFRAARLVKLLRQGYTIRLL 1345
Query: 3706 LWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVL 3885
LWTF++SF+ALPYV LLI +LF IYA+IGMQ FG + LD TSI+R+NNF SF A+L+L
Sbjct: 1346 LWTFLQSFKALPYVCLLIAMLFLIYAIIGMQVFGNIRLDSKTSINRHNNFRSFFYAVLLL 1405
Query: 3886 FRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFL 4065
FR ATGE+WQ IMLSC CDP S + ++ CG + AY YF++F LCSFL
Sbjct: 1406 FRCATGESWQQIMLSCLSGRP--CDPESK------MLDNSCGLDIAYIYFVTFIFLCSFL 1457
Query: 4066 VINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
++NLFVAVIMDNFDYLTRD SILGPHHL+E+ R+W+EYDP A GR+ + D+ +LR++ P
Sbjct: 1458 MLNLFVAVIMDNFDYLTRDTSILGPHHLDEYSRVWAEYDPLASGRVHYTDMYEMLRRMEP 1517
Query: 4246 PLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEG--NIDEANEQ 4419
P+GFG+ CP+RLAC++L+ MNMPL DGTV F+ TLFALVR +L I +D+ +E+
Sbjct: 1518 PVGFGRNCPYRLACRKLIRMNMPLKEDGTVHFSTTLFALVRESLSIRMSSAEEMDKKDEE 1577
Query: 4420 LRSAIKRIWKRTHKDLLDEVVPPAGKEDD--VTVGKFYATFLIQDYFRRFK 4566
+R IKR+W K ++D +VPP + ++ +TVGK Y LI + +R +K
Sbjct: 1578 MREVIKRVWPVQGKKIVDLLVPPNHELNNGKLTVGKVYGGLLIAENWRAYK 1628
Score = 505 bits (1301), Expect = e-141
Identities = 285/688 (41%), Positives = 377/688 (54%), Gaps = 47/688 (6%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
N IRK I+EW PFE+++L I ANCI LA+ + P +D LE E+ F+ +F
Sbjct: 62 NFIRKYAKIIIEWGPFEYMVLLTIIANCIVLALEEHLPNEDKTPLAVQLEATEFYFLGIF 121
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
+E +LKIVA+GF H +YLRN WNI+DF++VV G +S + S FD++ LRA RV
Sbjct: 122 CVEALLKIVALGFALHKGSYLRNVWNIMDFVVVVTGFISIFPASNS---FDLRTLRAVRV 178
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI-- 756
LRPL+LVSG+PSLQVVL +I+RAM PLL + LLVLF I+I+AIIGLE + G H C
Sbjct: 179 LRPLKLVSGIPSLQVVLKSIIRAMAPLLQVCLLVLFAIVIFAIIGLEFYTGAFHKACFIK 238
Query: 757 --DPATGQLAQKDPT---PCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGIT 921
D + D PC EGS + C+ + + W GPN GIT
Sbjct: 239 PNDDTEDNIEYGDEDTIRPCAN--EGSGYHCRANIAKLRFN----------WAGPNYGIT 286
Query: 922 NFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVL 1101
+FDN G AMLTVFQCV++EGWT V+Y+ +DAVG + WIYFV L++LGSFF+LNLVLGVL
Sbjct: 287 SFDNMGFAMLTVFQCVTMEGWTQVLYYTDDAVGDAYNWIYFVPLIVLGSFFMLNLVLGVL 346
Query: 1102 SGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVAQTX 1281
SGEF+KERE+ R F K R +QQ+E +L GYL+WI +AE++ ++E+ ++D+
Sbjct: 347 SGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWICKAEEV-ILDEERKKDDGTISDE 405
Query: 1282 XXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLV----------------- 1410
++ +MK ++L L+
Sbjct: 406 DKLRIIEGALGFNARRLAAQKVKKMKENKELTIGDEDNDGDLLSGINVGGSFGRGLKNRK 465
Query: 1411 -----------------------KSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTM 1521
++Q FYW S+HYGQ+EW F +
Sbjct: 466 AHGRCAGFWRAEKHLRFTIRKCVRTQGFYWVVIILVFLNTLCVASDHYGQAEWHTEFLYV 525
Query: 1522 ANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSV 1701
F+ LF EML++MY LG Y S FN FDC V++ SI+E + G+S
Sbjct: 526 MEFAFLALFMSEMLIRMYGLGVRLYFQSSFNIFDCVVILVSIIEVIWSAIKDGSSFGIST 585
Query: 1702 LRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFN 1881
LR+ RLLR+FKVT+YW+ GMQ+FGG N
Sbjct: 586 LRALRLLRMFKVTRYWSSLRNLVVSLLSSMRSIVSLLFLLFLFILIFALLGMQLFGGMMN 645
Query: 1882 FNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLF 2061
F ++ +P +FDTF ALLTVFQILTGEDWN VMY GI + G G Y+I+L
Sbjct: 646 F--EEGRPPGHFDTFPIALLTVFQILTGEDWNEVMYSGIRARGASPEEGCYTVHYFIILV 703
Query: 2062 ICGNYILLNVFLAIAVDNLADADSLTNA 2145
+ GNY LLNVFLAIAVDNLA+A LT A
Sbjct: 704 LFGNYTLLNVFLAIAVDNLANAQELTAA 731
Score = 142 bits (357), Expect = 1e-31
Identities = 96/312 (30%), Positives = 159/312 (50%), Gaps = 10/312 (3%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+R+ C +V + F+ I+ +ICA+ IALA P D N +L +YVF VF
Sbjct: 892 NPVRRFCHFVVNLRYFDLFIMIVICASSIALAAEDP--VNDESVNNQILNYFDYVFTGVF 949
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD-VKALRAFR 579
TIE +LKIV +G + HP +Y R+AWNILD +V+ LV+ + + +K+LR R
Sbjct: 950 TIEMLLKIVDLGIILHPGSYCRDAWNILDATVVICALVAFAFGDAAGGNLNTIKSLRVLR 1009
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+ ++ +P L+ V + ++ ++ + +I ++ L I+A+I ++LF GK C D
Sbjct: 1010 VLRPLKTINRIPKLKAVFDCVVNSLKNVSNILIVYLLFQFIFAVIAVQLFKGKFF-YCTD 1068
Query: 760 PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFG 939
+++ + C +G F + + N W + ++DN
Sbjct: 1069 -----MSKSNREEC----QGQYFDYEDESDKPRV-------KNREWLRQD---FHYDNVM 1109
Query: 940 LAMLTVFQCVSLEGWTDV----MYWVNDAVG-----REWPWIYFVTLVILGSFFVLNLVL 1092
AMLT+F + EGW V M +D +G R IY+V I+ FF +N+ +
Sbjct: 1110 FAMLTLFTVTTGEGWPMVLKNSMDSTSDDMGPKPGYRMEMAIYYVVFFIVFPFFFVNIFV 1169
Query: 1093 GVLSGEFSKERE 1128
++ F ++ E
Sbjct: 1170 ALIIITFQEQGE 1181
Score = 115 bits (287), Expect = 2e-23
Identities = 69/283 (24%), Positives = 141/283 (49%)
Frame = +1
Query: 3316 LQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAV 3495
L++ + V ++ F +V+ +++ +NT+ +A HY + +FL V F +F E +
Sbjct: 480 LRFTIRKCVRTQGFYWVVIILVFLNTLCVASDHYGQAEWHTEFLYVMEFAFLALFMSEML 539
Query: 3496 LKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKL 3675
+++ L + Y +N+FD +V++ S I++ + + G + I+ R R++R+ K+
Sbjct: 540 IRMYGLGVRLYFQSSFNIFDCVVILVSIIEVIWSAIKDGSS--FGISTLRALRLLRMFKV 597
Query: 3676 LSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNF 3855
+R L+ + + S +++ + L+ L I+A++GMQ FG + + +F
Sbjct: 598 TRYWSSLRNLVVSLLSSMRSIVSLLFLLFLFILIFALLGMQLFG--GMMNFEEGRPPGHF 655
Query: 3856 HSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYF 4035
+FP A+L +F+ TGE W ++M S +R +G E C + YF
Sbjct: 656 DTFPIALLTVFQILTGEDWNEVMYS-----GIRA--------RGASPEEGC---YTVHYF 699
Query: 4036 ISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVR 4164
I + ++ ++N+F+A+ +DN L + ++E VR
Sbjct: 700 IILVLFGNYTLLNVFLAIAVDN---LANAQELTAAEEIQEGVR 739
Score = 104 bits (260), Expect = 2e-20
Identities = 81/312 (25%), Positives = 142/312 (44%), Gaps = 15/312 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
N I+ +V FE +++ +I N + L + Y ++YK LL+ + F V+F
Sbjct: 1215 NSIKYKIWQVVVSPKFECVVMVLIALNTLVLMM--KYYGSPTEYK-LLLQNLNLAFSVLF 1271
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKM--SIQGFDVKALRAF 576
TIEC+LK++ G Y R+ WN+ DFIIV+ ++ + + + S F + R F
Sbjct: 1272 TIECILKLMGFGI----GNYFRDRWNMFDFIIVIGSIIDVVTTNVLPSASSFRTGSFRLF 1327
Query: 577 RVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI 756
R R ++L+ +++++L L++ L ++ LL+ + LIYAIIG+++F G +
Sbjct: 1328 RAARLVKLLRQGYTIRLLLWTFLQSFKALPYVCLLIAMLFLIYAIIGMQVF-GNIR---- 1382
Query: 757 DPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNF 936
DS T++ N NF +F
Sbjct: 1383 ----------------------------LDSKTSI----------------NRHNNFRSF 1398
Query: 937 GLAMLTVFQCVSLEGWTDVMY-------------WVNDAVGREWPWIYFVTLVILGSFFV 1077
A+L +F+C + E W +M ++++ G + +IYFVT + L SF +
Sbjct: 1399 FYAVLLLFRCATGESWQQIMLSCLSGRPCDPESKMLDNSCGLDIAYIYFVTFIFLCSFLM 1458
Query: 1078 LNLVLGVLSGEF 1113
LNL + V+ F
Sbjct: 1459 LNLFVAVIMDNF 1470
Score = 97.1 bits (240), Expect = 5e-18
Identities = 70/288 (24%), Positives = 130/288 (44%), Gaps = 25/288 (8%)
Frame = +1
Query: 2287 VPAASTVKPIPKASSL------FILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLA 2448
+P ++ +P +SS S N R + +++ F VL I+ + +LA
Sbjct: 34 LPVWDLLRTVPYSSSAKRTVPYSFFSEENFIRKYAKIIIEWGPFEYMVLLTIIANCIVLA 93
Query: 2449 AED--PLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILV 2622
E+ P + + + L +++F +F VE LK++ G HKGS+ RN +N++D +V
Sbjct: 94 LEEHLPNEDKTPLAVQLEATEFYFLGIFCVEALLKIVALGFALHKGSYLRNVWNIMDFVV 153
Query: 2623 VAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVT 2802
V S +++ ++ L+ V++ +I A+ + + L+
Sbjct: 154 VVTGFISIFPASNSFD-LRTLRAVRVLRPLKLVSGIPSLQVVLKSIIRAMAPLLQVCLLV 212
Query: 2803 FMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKP------------ 2946
+FAIIG++ + G F + + E + I Y D D +P
Sbjct: 213 LFAIVIFAIIGLEFYTGAFHKACFIKPNDDTE---DNIEYGDEDTIRPCANEGSGYHCRA 269
Query: 2947 -VSKKRV-WSNNDF---NFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
++K R W+ ++ +FDN+G AM+++F T EGW Q+LY D+
Sbjct: 270 NIAKLRFNWAGPNYGITSFDNMGFAMLTVFQCVTMEGWTQVLYYTDDA 317
Score = 88.6 bits (218), Expect = 2e-15
Identities = 70/322 (21%), Positives = 145/322 (44%), Gaps = 8/322 (2%)
Frame = +1
Query: 253 VEWKPFEFLILFMICAN--CIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKI 426
V + F ++++ ++ N C+A Y +++ L +E+ F+ +F E ++++
Sbjct: 488 VRTQGFYWVVIILVFLNTLCVASDHYG-----QAEWHTEFLYVMEFAFLALFMSEMLIRM 542
Query: 427 VAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSI-QGFDVKALRAFRVLRPLRLV 603
+G Y ++++NI D +++++ ++ I S + F + LRA R+LR ++
Sbjct: 543 YGLGVRL----YFQSSFNIFDCVVILVSIIEVIWSAIKDGSSFGISTLRALRLLRMFKVT 598
Query: 604 SGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ 783
SL+ ++ ++L +M ++ + L+ ILI+A++G++LF G +
Sbjct: 599 RYWSSLRNLVVSLLSSMRSIVSLLFLLFLFILIFALLGMQLF------------GGMMNF 646
Query: 784 KDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQ 963
++ P G +FD F +A+LTVFQ
Sbjct: 647 EEGRPPG---------------------------------------HFDTFPIALLTVFQ 667
Query: 964 CVSLEGWTDVMYWVNDAVGRE-----WPWIYFVTLVILGSFFVLNLVLGVLSGEFSKERE 1128
++ E W +VMY A G + YF+ LV+ G++ +LN+ L + + +E
Sbjct: 668 ILTGEDWNEVMYSGIRARGASPEEGCYTVHYFIILVLFGNYTLLNVFLAIAVDNLANAQE 727
Query: 1129 KARARGLFQKFREKQQLEEDLK 1194
A + + R++Q+ E K
Sbjct: 728 LTAAEEIQEGVRQEQEAAEKKK 749
Score = 80.1 bits (196), Expect = 6e-13
Identities = 70/301 (23%), Positives = 123/301 (40%), Gaps = 51/301 (16%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY++ L I+ N + LA + H P+ L+ F G+F EA+LKIVAL
Sbjct: 77 FEYMVLLTIIANCIVLALEEHLPNEDKTPLAVQLEATEFYFLGIFCVEALLKIVALGFAL 136
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WN+ D +VVV FI I +N + R RV+R +KL+S
Sbjct: 137 HKGSYLRNVWNIMDFVVVVTGFISIF------PASNSFDLRTLRAVRVLRPLKLVSGIPS 190
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFG---------------------- 3807
++ +L + +++ L V LL++ I+A+IG++F+
Sbjct: 191 LQVVLKSIIRAMAPLLQVCLLVLFAIVIFAIIGLEFYTGAFHKACFIKPNDDTEDNIEYG 250
Query: 3808 -----KVALDDSTSIHRNNN-----------------FHSFPAAILVLFRSATGEAWQDI 3921
+ ++ + H N F + A+L +F+ T E W +
Sbjct: 251 DEDTIRPCANEGSGYHCRANIAKLRFNWAGPNYGITSFDNMGFAMLTVFQCVTMEGWTQV 310
Query: 3922 MLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDN 4101
+ D G+ + + YF+ +L SF ++NL + V+
Sbjct: 311 LYYTDD---------------------AVGDAYNWIYFVPLIVLGSFFMLNLVLGVLSGE 349
Query: 4102 F 4104
F
Sbjct: 350 F 350
Score = 65.5 bits (158), Expect = 1e-08
Identities = 52/207 (25%), Positives = 85/207 (40%), Gaps = 10/207 (4%)
Frame = +1
Query: 1525 NLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLV-YFDLMKPLGVSV 1701
NL F +LF++E +LK+ G Y ++N FD +VI SI++ V
Sbjct: 1264 NLAFSVLFTIECILKLMGFGIGNYFRDRWNMFDFIIVIGSIIDVVTTNVLPSASSFRTGS 1323
Query: 1702 LRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFN 1881
R R R+ K+ + GMQVFG
Sbjct: 1324 FRLFRAARLVKLLRQGYTIRLLLWTFLQSFKALPYVCLLIAMLFLIYAIIGMQVFGNIRL 1383
Query: 1882 FNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGI-------ESFGGVGTLGVIVC 2040
+ NF +F A+L +F+ TGE W +M + ES + G+ +
Sbjct: 1384 DSKTSINRHNNFRSFFYAVLLLFRCATGESWQQIMLSCLSGRPCDPESKMLDNSCGLDIA 1443
Query: 2041 IYYIV--LFICGNYILLNVFLAIAVDN 2115
Y V +F+C ++++LN+F+A+ +DN
Sbjct: 1444 YIYFVTFIFLC-SFLMLNLFVAVIMDN 1469
Score = 51.6 bits (122), Expect = 2e-04
Identities = 51/229 (22%), Positives = 86/229 (37%), Gaps = 37/229 (16%)
Frame = +1
Query: 1534 FVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSV 1701
F +F++EMLLK+ LG +Y +N D VVI +++ F +
Sbjct: 945 FTGVFTIEMLLKIVDLGIILHPGSYCRDAWNILDATVVICALVAFAFGDAAGGNLNTIKS 1004
Query: 1702 LRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF- 1878
LR R+LR K +Q+F GKF
Sbjct: 1005 LRVLRVLRPLKTINRIPKLKAVFDCVVNSLKNVSNILIVYLLFQFIFAVIAVQLFKGKFF 1064
Query: 1879 ------------------NFNPQQPKPRA----------NFDTFVQALLTVFQILTGEDW 1974
++ + KPR ++D + A+LT+F + TGE W
Sbjct: 1065 YCTDMSKSNREECQGQYFDYEDESDKPRVKNREWLRQDFHYDNVMFAMLTLFTVTTGEGW 1124
Query: 1975 NTVMYHGIES----FGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
V+ + ++S G + + IYY+V FI + +N+F+A+ +
Sbjct: 1125 PMVLKNSMDSTSDDMGPKPGYRMEMAIYYVVFFIVFPFFFVNIFVALII 1173
Score = 47.4 bits (111), Expect = 0.004
Identities = 40/223 (17%), Positives = 95/223 (41%), Gaps = 3/223 (1%)
Frame = +1
Query: 2410 VLFCILVSSAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFC 2589
V+ ++ + + A D L ++ F ++F E+ +++ G+ +
Sbjct: 496 VVIILVFLNTLCVASDHYGQAEWHTEFLYVMEFAFLALFMSEMLIRMYGLGVRL----YF 551
Query: 2590 RNAFNLLDILVVAVSLTSFVLRT--DAMSXXXXXXXXXXXXXXXAINRA-KGLKHVVQCV 2760
+++FN+ D +V+ VS+ + D S + R L+++V +
Sbjct: 552 QSSFNIFDCVVILVSIIEVIWSAIKDGSSFGISTLRALRLLRMFKVTRYWSSLRNLVVSL 611
Query: 2761 IVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPT 2940
+ ++++I +++ + F+ +FA++G+QLF G +++E+G P
Sbjct: 612 LSSMRSIVSLLFLLFLFILIFALLGMQLF-------------------GGMMNFEEGRPP 652
Query: 2941 KPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAI 3069
+FD A++++F + T E W +++Y I
Sbjct: 653 G-------------HFDTFPIALLTVFQILTGEDWNEVMYSGI 682
>gi|31206787|ref|XP_312360.1| ENSANGP00000012088 [Anopheles gambiae]
gi|21295498|gb|EAA07643.1| ENSANGP00000012088 [Anopheles gambiae str.
PEST]
Length = 1571
Score = 691 bits (1784), Expect = 0.0
Identities = 415/1069 (38%), Positives = 558/1069 (51%), Gaps = 48/1069 (4%)
Frame = +1
Query: 790 PTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCV 969
PTPC D + + L N E + W GPN GITNFDN G AMLTVFQC+
Sbjct: 162 PTPCYDDDDTMNAELPAGVHLCNHN---ESACIEQWEGPNYGITNFDNIGFAMLTVFQCI 218
Query: 970 SLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGL 1149
++EGWT MYW NDA+G + WIYFV L+I+GSFF+LNLVLGVLSGEF++EREK R
Sbjct: 219 TMEGWTSTMYWTNDAIGSTFNWIYFVPLIIIGSFFMLNLVLGVLSGEFAREREKVENRQE 278
Query: 1150 FQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVAQTXXXXXXXXXXXXXXXXX 1329
F K R +QQLE++L G+++WI +AE+I + E+E +
Sbjct: 279 FLKLRRQQQLEKELNGFVEWICKAEEIILAEDRTTEEERM----------------YIME 322
Query: 1330 XPSKWAARMKRLEKLNXXXXXXXXX----------------------------------- 1404
K AA+ K+L+ L
Sbjct: 323 ARKKAAAKRKKLKNLGKSKSSETDDEEATTESGDEGILKKEKKPAKSGFWRAEKRFRYCI 382
Query: 1405 --LVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYS 1578
VK+Q FYW EHYGQ WL F A F+ LF EML+K+Y+
Sbjct: 383 RHTVKTQWFYWFVIVLVFLNTICVAVEHYGQPNWLALFLYYAEFVFLGLFMCEMLIKIYA 442
Query: 1579 LGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXX 1758
LG Y S FNRFDC V+ SI E V + G+SVLR+ RLLRIFKVTKYW+
Sbjct: 443 LGPRIYFESAFNRFDCIVIAGSIFEVVWSAYK-EGSFGISVLRALRLLRIFKVTKYWSSL 501
Query: 1759 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQAL 1938
GMQ+FGG+F + P NF+TF AL
Sbjct: 502 RNLVISLLSSMRSIISLLFLLFLFILIFALLGMQLFGGQFIL--PEGTPPTNFNTFTIAL 559
Query: 1939 LTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNL 2118
LTVFQILTGEDWN VMY GI S GG + G+I +Y+I+L + GNY LLNVFLAIAVDN
Sbjct: 560 LTVFQILTGEDWNEVMYLGINSQGGHES-GMIYSLYFIILTLFGNYTLLNVFLAIAVDN- 617
Query: 2119 ADADSLTNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSARPRRMSEVPAA 2298
L NA +T+A ++
Sbjct: 618 -----LANAQE----------------------------------LTAAEEQQQERDKEK 638
Query: 2299 STVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANST 2478
++ + + R + VVN YF ++ I +SS LAAEDP+Q +S
Sbjct: 639 QQME---------LEKEMEAMRRAAHWVVNLRYFDFFIMIVISLSSIALAAEDPVQEDSP 689
Query: 2479 RNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSF---V 2649
RN +LN DY FT VFT+E+ LKVI G++ H GS+ R +N++D +VV ++ S +
Sbjct: 690 RNKVLNNLDYAFTCVFTIEMLLKVIDLGIILHPGSYLREIWNIMDAVVVGCAVVSIGFDI 749
Query: 2650 LRTDA---MSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFM 2820
+DA +S I R LK V CV+ ++K + NI++V + QF+
Sbjct: 750 SGSDAGADLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVGSLKNVINILIVYILFQFI 809
Query: 2821 FAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVG 3000
FA+I VQLF G FF C D SK +C+G Y Y + D P S KR W FN+DNV
Sbjct: 810 FAVIAVQLFNGKFFYCTDDSKHNSIDCQGSYFIYSEVDGL-PRSAKREWKTQYFNYDNVA 868
Query: 3001 DAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXX 3180
AM++LF V T EGWPQ+L ++ + ED+GPI N R +++
Sbjct: 869 TAMLTLFAVQTGEGWPQVLQNSMAATYEDEGPIQNFRIEMSIFYVVYFVVFPFFFVNIFV 928
Query: 3181 GFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRA 3354
+I+TFQ +GE E ++ E+DKNQ+ CI+F + A+P RYIP +Y VW + S
Sbjct: 929 ALIIITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYIPTKHSGFKYTVWRIIVSAP 988
Query: 3355 FEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYIS 3534
FEY I +IV NT+ L K + ++ E+F+ N+IFTG+F+ E VLKI+ +N+
Sbjct: 989 FEYFIMTLIVFNTLLLMMKCHDQNKKLENFMKYLNMIFTGMFSVETVLKIIGFGARNFFK 1048
Query: 3535 DRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWT 3714
D WNVFDL+ V+GS +D L N ++ F RLFR RL+KLL +G+ IR LLWT
Sbjct: 1049 DAWNVFDLITVIGSIVDALILLL---WENSFNVGFLRLFRAARLIKLLRQGDTIRILLWT 1105
Query: 3715 FMKSFQALPYVALLIVLLFFIYAVIGMQ---FFGKVALDDSTSIHRNNN 3852
F++SF+ALPYV LLI +LFFIYA+IGMQ F V +D+ + R+++
Sbjct: 1106 FVQSFKALPYVCLLIAMLFFIYAIIGMQMLNLFVAVIMDNFDYLTRDSS 1154
Score = 176 bits (445), Expect = 8e-42
Identities = 131/387 (33%), Positives = 190/387 (48%), Gaps = 41/387 (10%)
Frame = +1
Query: 4045 FMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVT 4224
+ + ++NLFVAVIMDNFDYLTRD SILG HHL+EFVR+W+EYDP A G++ + ++
Sbjct: 1127 YAIIGMQMLNLFVAVIMDNFDYLTRDSSILGAHHLDEFVRIWAEYDPSASGKLHYTEMYD 1186
Query: 4225 LLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNL--KIYTEGN 4398
+L+ ++PPLGFG CP+RLA K+L+ MNMP++ +G V F TLFAL+R NL K+
Sbjct: 1187 MLKNMAPPLGFGNKCPNRLAYKKLIRMNMPVDEEGRVGFTTTLFALIRENLSIKMRPAEE 1246
Query: 4399 IDEANEQLRSAIKRIWKRTHKDLLDEVVPPAG--KEDDVTVGKFYATFLIQDYFRRFKKR 4572
+D+A+ +LR I++IW K ++D +VPP +TVGK YA L+ + +R K
Sbjct: 1247 MDQADMELRQTIRQIWPIQAKKMVDLLVPPNNVLNTGKMTVGKIYAGILMLETWRNNKGA 1306
Query: 4573 K---EMEAKGVLPAQTPQAMALQAGLR-----------TLHEIGPELKRAIS-GNLETDF 4707
+ E E + P + + L +LH G L+R+ S +L D
Sbjct: 1307 RYDFEPELQEHKPHEIQEPYIDDGHLHPDQRNGHVRSPSLHRRGSALERSPSPRHLHHDI 1366
Query: 4708 NFDEPEPQ----HRRPHSLFNN----------LVHRLSGAG-SKSPTEHERIEKGSTLLP 4842
F E RR H + + HR G P + ++ ST +
Sbjct: 1367 GFSETVSNVVEIARRDHLIVSRPYIQHTYPVLQSHRDFGRRLPPRPIKPTTLQLKSTNIN 1426
Query: 4843 FQPRSFSPTHS--LAGAEGSPVPSQMHRGAPINQSINLPPVNGSARRLPALPPYANHIHD 5016
F + SPTH +P +H +LP GS +P P +H
Sbjct: 1427 FPQLNTSPTHQNLHLALNTHTLPYSVH---------SLP---GSRGDIPRDPRIYHHTES 1474
Query: 5017 ETDD-----GPRYRDTGDRAGYDQSSR 5082
E D R RD G R + + R
Sbjct: 1475 ERDRERERLRERERDYGSRYVFRDTER 1501
Score = 145 bits (365), Expect = 1e-32
Identities = 126/520 (24%), Positives = 226/520 (43%), Gaps = 18/520 (3%)
Frame = +1
Query: 229 IRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTI 408
+R+ +V + F+F I+ +I + IALA P Q+ +N +L ++Y F VFTI
Sbjct: 650 MRRAAHWVVNLRYFDFFIMIVISLSSIALAAEDP--VQEDSPRNKVLNNLDYAFTCVFTI 707
Query: 409 ECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD-------VKAL 567
E +LK++ +G + HP +YLR WNI+D ++V +VS I G D +K+L
Sbjct: 708 EMLLKVIDLGIILHPGSYLREIWNIMDAVVVGCAVVSI---GFDISGSDAGADLSTIKSL 764
Query: 568 RAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHS 747
R RVLRPL+ + VP L+ V + ++ ++ +++I ++ + I+A+I ++LF GK
Sbjct: 765 RVLRVLRPLKTIKRVPKLKAVFDCVVGSLKNVINILIVYILFQFIFAVIAVQLFNGKFF- 823
Query: 748 TCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNF 927
C D D D +GS F D L S+ W N+
Sbjct: 824 YCTD---------DSKHNSIDCQGSYFIYSEVDGLPR-------SAKREW---KTQYFNY 864
Query: 928 DNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGR-EWP--------WIYFVTLVILGSFFVL 1080
DN AMLT+F + EGW V+ A E P I++V ++ FF +
Sbjct: 865 DNVATAMLTLFAVQTGEGWPQVLQNSMAATYEDEGPIQNFRIEMSIFYVVYFVVFPFFFV 924
Query: 1081 NLVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQED 1260
N+ + ++ F ++ E G +++++ K +D+ A +E
Sbjct: 925 NIFVALIIITFQEQGEAELQDG---------EIDKNQKSCIDFTIGARPLE--------- 966
Query: 1261 EPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXX 1440
P+K + ++ S F +
Sbjct: 967 ---------------------RYIPTK-----------HSGFKYTVWRIIVSAPFEYFIM 994
Query: 1441 XXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRF 1620
+ + Q++ L++F N+ F +FS+E +LK+ G + +N F
Sbjct: 995 TLIVFNTLLLMMKCHDQNKKLENFMKYLNMIFTGMFSVETVLKIIGFGARNFFKDAWNVF 1054
Query: 1621 DCFVVISSILE-FVLVYFDLMKPLG-VSVLRSARLLRIFK 1734
D VI SI++ +L+ ++ +G + + R+ARL+++ +
Sbjct: 1055 DLITVIGSIVDALILLLWENSFNVGFLRLFRAARLIKLLR 1094
Score = 115 bits (289), Expect = 9e-24
Identities = 70/264 (26%), Positives = 132/264 (49%), Gaps = 1/264 (0%)
Frame = +1
Query: 3313 RLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEA 3492
R +Y + V ++ F + + +++ +NT+ +A +HY FL +F G+F E
Sbjct: 377 RFRYCIRHTVKTQWFYWFVIVLVFLNTICVAVEHYGQPNWLALFLYYAEFVFLGLFMCEM 436
Query: 3493 VLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVK 3672
++KI AL P+ Y +N FD +V+ GS ++ + G I+ R R++R+ K
Sbjct: 437 LIKIYALGPRIYFESAFNRFDCIVIAGSIFEVVWSAYKEGS---FGISVLRALRLLRIFK 493
Query: 3673 LLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNN 3849
+ +R L+ + + S +++ + L+ L I+A++GMQ F G+ L + T
Sbjct: 494 VTKYWSSLRNLVISLLSSMRSIISLLFLLFLFILIFALLGMQLFGGQFILPEGTP---PT 550
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF++F A+L +F+ TGE W ++M + S H+ G+ S
Sbjct: 551 NFNTFTIALLTVFQILTGEDWNEVMYLGIN---------SQGGHESGMIYSL-------- 593
Query: 4030 YFISFFMLCSFLVINLFVAVIMDN 4101
YFI + ++ ++N+F+A+ +DN
Sbjct: 594 YFIILTLFGNYTLLNVFLAIAVDN 617
Score = 97.1 bits (240), Expect = 5e-18
Identities = 81/315 (25%), Positives = 141/315 (44%), Gaps = 6/315 (1%)
Frame = +1
Query: 256 EWKPFEFLILFMICANCIALAIY-QPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVA 432
+W + ++L + C+A+ Y QP ++ L E+VF+ +F E ++KI A
Sbjct: 389 QWFYWFVIVLVFLNTICVAVEHYGQP------NWLALFLYYAEFVFLGLFMCEMLIKIYA 442
Query: 433 MGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGV 612
+G P Y +A+N D I++ + + S F + LRA R+LR ++
Sbjct: 443 LG----PRIYFESAFNRFDCIVIAGSIFEVVWSAYKEGSFGISVLRALRLLRIFKVTKYW 498
Query: 613 PSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDP 792
SL+ ++ ++L +M ++ + L+ ILI+A++G++LF GQ +
Sbjct: 499 SSLRNLVISLLSSMRSIISLLFLLFLFILIFALLGMQLF------------GGQFILPEG 546
Query: 793 TPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVS 972
TP TNF+ F +A+LTVFQ ++
Sbjct: 547 TP---------------------------------------PTNFNTFTIALLTVFQILT 567
Query: 973 LEGWTDVMY-WVNDAVGREWPWI---YFVTLVILGSFFVLNLVLGVLSGEFSKEREKARA 1140
E W +VMY +N G E I YF+ L + G++ +LN+ L + + +E A
Sbjct: 568 GEDWNEVMYLGINSQGGHESGMIYSLYFIILTLFGNYTLLNVFLAIAVDNLANAQELTAA 627
Query: 1141 RGLFQ-KFREKQQLE 1182
Q + +EKQQ+E
Sbjct: 628 EEQQQERDKEKQQME 642
Score = 94.7 bits (234), Expect = 2e-17
Identities = 45/100 (45%), Positives = 60/100 (60%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N IRK I+EW PFE+ +L I ANC+ LA+ + P D LE E F+ +
Sbjct: 49 DNFIRKATKFIIEWPPFEYAVLLTIIANCVVLALEEHLPKGDKTVLAQKLELTESYFLCI 108
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVS 519
FTIE LKIVA+G + H +YLRN WN++DF +V G S
Sbjct: 109 FTIEAALKIVALGLVLHADSYLRNIWNMMDFFVVFTGCYS 148
Score = 74.7 bits (182), Expect = 2e-11
Identities = 43/160 (26%), Positives = 86/160 (52%), Gaps = 1/160 (0%)
Frame = +1
Query: 250 IVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYK-NTLLETIEYVFIVVFTIECVLKI 426
I+ PFE+ I+ +I N + L + D + K ++ + +F +F++E VLKI
Sbjct: 983 IIVSAPFEYFIMTLIVFNTLLLMM----KCHDQNKKLENFMKYLNMIFTGMFSVETVLKI 1038
Query: 427 VAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVS 606
+ G + ++AWN+ D I V+ +V ++ + F+V LR FR R ++L+
Sbjct: 1039 IGFG----ARNFFKDAWNVFDLITVIGSIVDALILLLWENSFNVGFLRLFRAARLIKLLR 1094
Query: 607 GVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLEL 726
+++++L +++ L ++ LL+ + IYAIIG+++
Sbjct: 1095 QGDTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQM 1134
Score = 66.6 bits (161), Expect = 7e-09
Identities = 38/114 (33%), Positives = 56/114 (48%), Gaps = 2/114 (1%)
Frame = +1
Query: 2290 PAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQA 2469
P T P P SSLFI + N R ++ F AVL I+ + +LA E+ L
Sbjct: 29 PRHRTGPPPPGPSSLFIFAEDNFIRKATKFIIEWPPFEYAVLLTIIANCVVLALEEHLPK 88
Query: 2470 NSTRNMI--LNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
+ L + +F +FT+E LK++ GLV H S+ RN +N++D VV
Sbjct: 89 GDKTVLAQKLELTESYFLCIFTIEAALKIVALGLVLHADSYLRNIWNMMDFFVV 142
Score = 41.6 bits (96), Expect = 0.22
Identities = 28/78 (35%), Positives = 39/78 (49%), Gaps = 7/78 (8%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSSRG--FEDFLDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY + L I+ N V LA + H P L++ F +F EA LKIVAL
Sbjct: 65 FEYAVLLTIIANCVVLALEEHLPKGDKTVLAQKLELTESYFLCIFTIEAALKIVALGLVL 124
Query: 3514 NPKNYISDRWNVFDLLVV 3567
+ +Y+ + WN+ D VV
Sbjct: 125 HADSYLRNIWNMMDFFVV 142
>gi|29378319|gb|AAO83841.1| voltage-dependent non-L-type calcium
channel alpha-1 subunit isoform A [Lymnaea stagnalis]
Length = 2141
Score = 687 bits (1774), Expect = 0.0
Identities = 359/766 (46%), Positives = 488/766 (62%), Gaps = 13/766 (1%)
Frame = +1
Query: 2308 KPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNM 2487
KP+ SS+FI TN R FC+ VVN YF ++ I SS LAAEDP+ NS RN
Sbjct: 848 KPMLPYSSMFIFGPTNPIRRFCHFVVNLRYFDLFIMIVICASSVALAAEDPVIENSRRNE 907
Query: 2488 ILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAM 2667
ILNYFD+ FT VFT+E+ LKVI G++ H GS+ R+ +N+LD VV +L +FV + +
Sbjct: 908 ILNYFDFVFTGVFTIELVLKVIDLGVLLHPGSYIRDLWNILDATVVICALVAFVFKDKSD 967
Query: 2668 SXXXXXXXXXXXXXXXA------INRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAI 2829
S INR LK V CV+ ++K + NI++V + QF+FA+
Sbjct: 968 SAGKNLNTIKSLRVLRVLRPLKTINRVPKLKAVFDCVVNSLKNVSNILIVYILFQFIFAV 1027
Query: 2830 IGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAM 3009
I VQLFKG FF C D SK T EC+G++ Y DG P + R W DF++DN+ AM
Sbjct: 1028 IAVQLFKGRFFYCTDESKSTRDECQGQFFEY-DGHSNDPTVRDREWLRQDFHYDNIMMAM 1086
Query: 3010 ISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFV 3189
++LF V+T EGWP +L ++DS ED+GP R ++L +
Sbjct: 1087 LTLFTVTTGEGWPSVLKHSMDSTYEDRGPKPVYRMEMSLFYVVFFIVFPFFFVNIFVALI 1146
Query: 3190 IVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRAFEY 3363
I+TFQ +GE E + E+DKNQ++CI+FA+ AKPH R+IP+N+ ++Y++W V S FEY
Sbjct: 1147 IITFQEQGENELMDQEMDKNQKQCIDFAINAKPHCRFIPKNKNSIKYKIWRLVQSSKFEY 1206
Query: 3364 VIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRW 3543
+ +I +NT+ L K+ S ++D L N FT +F E +LKI+ L P+NY D W
Sbjct: 1207 FVMTLITLNTIVLMMKYDGMSDNYKDVLAKLNEGFTVLFTLECLLKIIGLGPRNYFHDPW 1266
Query: 3544 NVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMK 3723
NVFD VVGS ID+ + + +S FFRLFR RLVKLL +G IR LLWTF +
Sbjct: 1267 NVFDFTTVVGSIIDVLITEFSK---RQVSFGFFRLFRAARLVKLLRQGYTIRLLLWTFFQ 1323
Query: 3724 SFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATG 3903
SF+ALPYV LLI++LFFIYA+IGMQ FG + LD TSI+R+NNF +F +A+ +LFR ATG
Sbjct: 1324 SFKALPYVCLLILMLFFIYAIIGMQVFGSIKLDSKTSINRHNNFRTFFSALTLLFRCATG 1383
Query: 3904 EAWQDIMLSCSDREDVRCDPMS-DDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLF 4080
EAWQ IM SC + CDP S D + ES CG N AY YF+SF LCSFL++NLF
Sbjct: 1384 EAWQQIMQSCLAGQP--CDPESIRDDDPPDMAESGCGTNIAYMYFVSFIFLCSFLMLNLF 1441
Query: 4081 VAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFG 4260
VAVIMDNFDYLTRD SILGPHHL+E+VR+WS YDP A GRI + D+ +LR + PP+GFG
Sbjct: 1442 VAVIMDNFDYLTRDSSILGPHHLDEYVRVWSMYDPKATGRIHYTDMYEMLRNMEPPVGFG 1501
Query: 4261 KLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNL--KIYTEGNIDEANEQLRSAI 4434
K CP++LA ++L+ MNMP+ DGTV F TLFAL+R L K+ +D +E++R I
Sbjct: 1502 KKCPYKLAYRKLIRMNMPVAEDGTVHFTTTLFALIRECLIIKMGPAEIMDRRDEEMRETI 1561
Query: 4435 KRIWKRTHKDLLDEVVPPAGKEDD--VTVGKFYATFLIQDYFRRFK 4566
+++W K ++D ++PP+ + D+ ++VGK YA LI + ++ +K
Sbjct: 1562 RKLWPVQGKKMMDMLMPPSDELDEGKMSVGKIYAGLLISENWKAYK 1607
Score = 527 bits (1357), Expect = e-147
Identities = 301/686 (43%), Positives = 389/686 (55%), Gaps = 45/686 (6%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
N IRK I+EW PFE+++L I ANCI LA+ + P+QD L+ E F+ +F
Sbjct: 54 NFIRKYAKIIIEWGPFEYMVLLTIIANCIVLALEEHLPSQDKTPLALQLDDTEVYFLGIF 113
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
+E LKIVA+GF H +YLRN WNI+DFI+VV G + T+ ++ S FD++ LRA RV
Sbjct: 114 CVEAFLKIVALGFCLHKRSYLRNIWNIMDFIVVVTGFI-TLFAQGSSTTFDLRTLRAVRV 172
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI-- 756
LRPL+LVSG+PSLQVVL +I+RAM PLL + LLVLF I+I+AIIGLE + G H+ C
Sbjct: 173 LRPLKLVSGIPSLQVVLKSIIRAMAPLLQVCLLVLFAIVIFAIIGLEFYVGVFHNACYKK 232
Query: 757 --------DPATGQLAQKDPTPCGTDTEGS-AFKCQPSDSLTNMGVRWECSSNTTWPGPN 909
D TG + D PC +E AF+CQ + S G W GPN
Sbjct: 233 GSHTRSEDDIDTGD--EDDIRPCLPSSESQGAFQCQVNISNCKAG----------WRGPN 280
Query: 910 NGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLV 1089
GIT+FDN G AMLTVFQC+++EGWT+V+Y+ NDA+G ++ ++YF+ L+ILGSFF+LNLV
Sbjct: 281 AGITSFDNIGYAMLTVFQCITMEGWTNVLYYTNDALGNQFNFLYFIPLIILGSFFMLNLV 340
Query: 1090 LGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDI------------- 1230
LGVLSGEF+KERE+ R F K R +QQ+E +L GYL+WI +AE++
Sbjct: 341 LGVLSGEFAKERERVENRRAFFKLRRQQQIERELNGYLEWICKAEEVILSEERTTDEEKL 400
Query: 1231 --------------------EPVNEDEQED-EPVAQTXXXXXXXXXXXXXXXXXXPSKWA 1347
+ N+ EQ D + +A S W
Sbjct: 401 KIIEARRQAAARKMKQLKAEDNENDSEQNDNDLLAAMAPGNSFKSMKKRRTTGKCASFWR 460
Query: 1348 ARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMAN 1527
A + LVKSQ FYW SEHY Q EW F +
Sbjct: 461 AEKR--------FRYSIRRLVKSQLFYWIVIVLVFLNTASVASEHYNQPEWHVQFLYITE 512
Query: 1528 LFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLR 1707
F+ LF EM +KMY+LG Y S FN FDC V++ SI+E + F G+SVLR
Sbjct: 513 YAFLGLFIFEMSIKMYALGVRMYFQSSFNIFDCVVIVGSIVEVIWSEFKRGSSFGISVLR 572
Query: 1708 SARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFN 1887
+ RLLRIFKVT+YW+ GMQ+FGG+ NF
Sbjct: 573 ALRLLRIFKVTRYWSSLRNLVISLLSSMRSILSLLFLLFLFIIVFALLGMQLFGGEMNF- 631
Query: 1888 PQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFIC 2067
++ +P A+FDTF ALLTVFQILTGEDWN VMY+GI+S GG+ G+ Y+IVL +
Sbjct: 632 -EEGRPSAHFDTFPIALLTVFQILTGEDWNEVMYNGIKSHGGIENQGMFYSSYFIVLVLF 690
Query: 2068 GNYILLNVFLAIAVDNLADADSLTNA 2145
GNY LLNVFLAIAVDNLA+A LT A
Sbjct: 691 GNYTLLNVFLAIAVDNLANAQELTAA 716
Score = 171 bits (434), Expect = 1e-40
Identities = 152/666 (22%), Positives = 271/666 (39%), Gaps = 35/666 (5%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR+ C +V + F+ I+ +ICA+ +ALA P ++ +N +L ++VF VF
Sbjct: 863 NPIRRFCHFVVNLRYFDLFIMIVICASSVALAAEDP--VIENSRRNEILNYFDFVFTGVF 920
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG----FDVKALR 570
TIE VLK++ +G + HP +Y+R+ WNILD +V+ LV+ + S +K+LR
Sbjct: 921 TIELVLKVIDLGVLLHPGSYIRDLWNILDATVVICALVAFVFKDKSDSAGKNLNTIKSLR 980
Query: 571 AFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHST 750
RVLRPL+ ++ VP L+ V + ++ ++ + +I ++ + I+A+I ++LF G+
Sbjct: 981 VLRVLRPLKTINRVPKLKAVFDCVVNSLKNVSNILIVYILFQFIFAVIAVQLFKGRFFY- 1039
Query: 751 CIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNN-----G 915
C +++ + +CQ G +E ++ P +
Sbjct: 1040 ----------------CTDESKSTRDECQ--------GQFFEYDGHSNDPTVRDREWLRQ 1075
Query: 916 ITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDA---------VGREWPWIYFVTLVILGS 1068
++DN +AMLT+F + EGW V+ D+ V R +++V I+
Sbjct: 1076 DFHYDNIMMAMLTLFTVTTGEGWPSVLKHSMDSTYEDRGPKPVYRMEMSLFYVVFFIVFP 1135
Query: 1069 FFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNED 1248
FF +N+ + ++ F ++ E Q+++++ K +D+ A+
Sbjct: 1136 FFFVNIFVALIIITFQEQGENELM---------DQEMDKNQKQCIDFAINAK-------- 1178
Query: 1249 EQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFY 1428
+ + K LV+S F
Sbjct: 1179 ---------------------------------PHCRFIPKNKNSIKYKIWRLVQSSKFE 1205
Query: 1429 WXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQ 1608
+ ++ G S+ N F +LF++E LLK+ LG Y
Sbjct: 1206 YFVMTLITLNTIVLMMKYDGMSDNYKDVLAKLNEGFTVLFTLECLLKIIGLGPRNYFHDP 1265
Query: 1609 FNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXX 1788
+N FD V+ SI++ ++ F + + R R R+ K+ +
Sbjct: 1266 WNVFDFTTVVGSIIDVLITEFS-KRQVSFGFFRLFRAARLVKLLRQGYTIRLLLWTFFQS 1324
Query: 1789 XXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGE 1968
GMQVFG + NF TF AL +F+ TGE
Sbjct: 1325 FKALPYVCLLILMLFFIYAIIGMQVFGSIKLDSKTSINRHNNFRTFFSALTLLFRCATGE 1384
Query: 1969 DWNTVMYHGI-------ESF----------GGVGTLGVIVCIYYIVLFICGNYILLNVFL 2097
W +M + ES G GT I +Y++ ++++LN+F+
Sbjct: 1385 AWQQIMQSCLAGQPCDPESIRDDDPPDMAESGCGT--NIAYMYFVSFIFLCSFLMLNLFV 1442
Query: 2098 AIAVDN 2115
A+ +DN
Sbjct: 1443 AVIMDN 1448
Score = 123 bits (309), Expect = 4e-26
Identities = 69/264 (26%), Positives = 137/264 (51%), Gaps = 1/264 (0%)
Frame = +1
Query: 3313 RLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEA 3492
R +Y + V S+ F +++ +++ +NT S+A +HY FL + F G+F FE
Sbjct: 464 RFRYSIRRLVKSQLFYWIVIVLVFLNTASVASEHYNQPEWHVQFLYITEYAFLGLFIFEM 523
Query: 3493 VLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVK 3672
+K+ AL + Y +N+FD +V+VGS +++ + + G + I+ R R++R+ K
Sbjct: 524 SIKMYALGVRMYFQSSFNIFDCVVIVGSIVEVIWSEFKRGSS--FGISVLRALRLLRIFK 581
Query: 3673 LLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNN 3849
+ +R L+ + + S +++ + L+ L ++A++GMQ F G++ ++ +
Sbjct: 582 VTRYWSSLRNLVISLLSSMRSILSLLFLLFLFIIVFALLGMQLFGGEMNFEEG---RPSA 638
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
+F +FP A+L +F+ TGE W ++M + H G N+ F
Sbjct: 639 HFDTFPIALLTVFQILTGEDWNEVMYN------------GIKSHGGIENQGM----FYSS 682
Query: 4030 YFISFFMLCSFLVINLFVAVIMDN 4101
YFI + ++ ++N+F+A+ +DN
Sbjct: 683 YFIVLVLFGNYTLLNVFLAIAVDN 706
Score = 93.2 bits (230), Expect = 6e-17
Identities = 70/270 (25%), Positives = 117/270 (42%), Gaps = 21/270 (7%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMILNYFD- 2505
SLFI S N R + +++ F VL I+ + +LA E+ L + + L D
Sbjct: 46 SLFIFSEENFIRKYAKIIIEWGPFEYMVLLTIIANCIVLALEEHLPSQDKTPLALQLDDT 105
Query: 2506 -YFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVS-LTSFVLRTDAMSXXX 2679
+F +F VE LK++ G HK S+ RN +N++D +VV +T F +
Sbjct: 106 EVYFLGIFCVEAFLKIVALGFCLHKRSYLRNIWNIMDFIVVVTGFITLFAQGSSTTFDLR 165
Query: 2680 XXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTF 2859
++ L+ V++ +I A+ + + L+ +FAIIG++ + G F
Sbjct: 166 TLRAVRVLRPLKLVSGIPSLQVVLKSIIRAMAPLLQVCLLVLFAIVIFAIIGLEFYVGVF 225
Query: 2860 F-LCNDLSKMTEAECRGEYIHYEDGDPTKPVSK--------------KRVWSNND---FN 2985
C T +E + +D P P S+ K W + +
Sbjct: 226 HNACYKKGSHTRSEDDIDTGDEDDIRPCLPSSESQGAFQCQVNISNCKAGWRGPNAGITS 285
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
FDN+G AM+++F T EGW +LY D+
Sbjct: 286 FDNIGYAMLTVFQCITMEGWTNVLYYTNDA 315
Score = 86.3 bits (212), Expect = 8e-15
Identities = 75/305 (24%), Positives = 129/305 (41%), Gaps = 55/305 (18%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACKHYPSSRGFEDF---LDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY++ L I+ N + LA + + S+ LD + F G+F EA LKIVAL
Sbjct: 69 FEYMVLLTIIANCIVLALEEHLPSQDKTPLALQLDDTEVYFLGIFCVEAFLKIVALGFCL 128
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ ++Y+ + WN+ D +VVV FI + G + + R RV+R +KL+S
Sbjct: 129 HKRSYLRNIWNIMDFIVVVTGFITL----FAQGSSTTFDLRTLRAVRVLRPLKLVSGIPS 184
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKV-------------------- 3813
++ +L + +++ L V LL++ I+A+IG++F+ V
Sbjct: 185 LQVVLKSIIRAMAPLLQVCLLVLFAIVIFAIIGLEFYVGVFHNACYKKGSHTRSEDDIDT 244
Query: 3814 --------ALDDSTS-------IHRNN-------------NFHSFPAAILVLFRSATGEA 3909
L S S ++ +N +F + A+L +F+ T E
Sbjct: 245 GDEDDIRPCLPSSESQGAFQCQVNISNCKAGWRGPNAGITSFDNIGYAMLTVFQCITMEG 304
Query: 3910 WQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAV 4089
W +++ +D GN F + YFI +L SF ++NL + V
Sbjct: 305 WTNVLYYTND---------------------ALGNQFNFLYFIPLIILGSFFMLNLVLGV 343
Query: 4090 IMDNF 4104
+ F
Sbjct: 344 LSGEF 348
Score = 83.2 bits (204), Expect = 7e-14
Identities = 74/319 (23%), Positives = 145/319 (45%), Gaps = 6/319 (1%)
Frame = +1
Query: 250 IVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIV 429
+V+ + F ++++ ++ N ++A ++ L EY F+ +F E +K+
Sbjct: 472 LVKSQLFYWIVIVLVFLNTASVASEH---YNQPEWHVQFLYITEYAFLGLFIFEMSIKMY 528
Query: 430 AMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSI-QGFDVKALRAFRVLRPLRLVS 606
A+G Y ++++NI D +++V +V I S+ F + LRA R+LR ++
Sbjct: 529 ALGVRM----YFQSSFNIFDCVVIVGSIVEVIWSEFKRGSSFGISVLRALRLLRIFKVTR 584
Query: 607 GVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQK 786
SL+ ++ ++L +M +L + L+ I+++A++G++LF G+++
Sbjct: 585 YWSSLRNLVISLLSSMRSILSLLFLLFLFIIVFALLGMQLFGGEMNFE------------ 632
Query: 787 DPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQC 966
EG +PS +FD F +A+LTVFQ
Sbjct: 633 ---------EG-----RPS-------------------------AHFDTFPIALLTVFQI 653
Query: 967 VSLEGWTDVMY-WVNDAVGREWPWI----YFVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
++ E W +VMY + G E + YF+ LV+ G++ +LN+ L + + +E
Sbjct: 654 LTGEDWNEVMYNGIKSHGGIENQGMFYSSYFIVLVLFGNYTLLNVFLAIAVDNLANAQEL 713
Query: 1132 ARARGLFQKFREKQQLEED 1188
A E++Q EE+
Sbjct: 714 TAA--------EEEQEEEE 724
Score = 51.6 bits (122), Expect = 2e-04
Identities = 48/255 (18%), Positives = 111/255 (42%), Gaps = 5/255 (1%)
Frame = +1
Query: 2359 FRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEI 2538
FR +V F V+ + +++A +A+E Q L +Y F +F E+
Sbjct: 465 FRYSIRRLVKSQLFYWIVIVLVFLNTASVASEHYNQPE-WHVQFLYITEYAFLGLFIFEM 523
Query: 2539 TLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFV---LRTDAMSXXXXXXXXXXXXX 2709
++K+ G+ + +++FN+ D +V+ S+ + + +
Sbjct: 524 SIKMYALGVRM----YFQSSFNIFDCVVIVGSIVEVIWSEFKRGSSFGISVLRALRLLRI 579
Query: 2710 XXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMT 2889
L+++V ++ ++++I +++ + F+ +FA++G+QLF G
Sbjct: 580 FKVTRYWSSLRNLVISLLSSMRSILSLLFLLFLFIIVFALLGMQLFGGE----------- 628
Query: 2890 EAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAI 3069
+++E+G P+ +FD A++++F + T E W +++Y I
Sbjct: 629 --------MNFEEGRPSA-------------HFDTFPIALLTVFQILTGEDWNEVMYNGI 667
Query: 3070 DSNE--EDKGPIHNS 3108
S+ E++G ++S
Sbjct: 668 KSHGGIENQGMFYSS 682
>gi|6978579|ref|NP_037050.1| calcium channel, voltage-dependent, alpha
1A subunit; Calcium channel alpha 1A [Rattus norvegicus]
gi|1705706|sp|P54282|CCAA_RAT Voltage-dependent P/Q-type calcium
channel alpha-1A subunit (Voltage-gated calcium channel
alpha subunit Cav2.1) (Calcium channel, L type, alpha-1
polypeptide, isoform 4) (Brain calcium channel I) (BI)
(RAT brain class A) (RBA-I)
gi|111447|pir||A41098 calcium channel protein alpha-1 chain isoform A
- rat
gi|203111|gb|AAA40806.1| calcium channel alpha-1 subunit
Length = 2212
Score = 683 bits (1762), Expect = 0.0
Identities = 403/1025 (39%), Positives = 568/1025 (55%), Gaps = 60/1025 (5%)
Frame = +1
Query: 2290 PAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQA 2469
P KP+P SS+FILS TN R C+ ++N YF +L I +SS LAAEDP+Q
Sbjct: 1161 PGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQP 1220
Query: 2470 NSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFV 2649
N+ RN +L YFDY FT VFT E+ +K+I GLV H+G++ R+ +N+LD +VV+ +L +F
Sbjct: 1221 NAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFA 1280
Query: 2650 LRTDA----MSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQF 2817
++ ++ I R LK V CV+ ++K + NI++V + F
Sbjct: 1281 FTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMF 1340
Query: 2818 MFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNV 2997
+FA++ VQLFKG FF C D SK E +CRG+Y+ YE + ++ R W DF++DNV
Sbjct: 1341 IFAVVAVQLFKGKFFHCTDESKEFERDCRGKYLLYEKNEVK---ARDREWKKYDFHYDNV 1397
Query: 2998 GDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXX 3177
A+++LF VST EGWPQ+L ++D+ E++GP R +++
Sbjct: 1398 LWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIF 1457
Query: 3178 XGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSR 3351
+I+TFQ +G++ E L+KN+R CI+FA+ AKP R++P+N+ QYR+W FV S
Sbjct: 1458 VALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSP 1517
Query: 3352 AFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYI 3531
FEY I +I +NT+ L K Y +S +E+ L VFN++FT +F+ E VLK++A NY
Sbjct: 1518 PFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYF 1577
Query: 3532 SDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLW 3711
D WN+FD + V+GS DI + G N I+++F RLFR RL+KLL +G IR LLW
Sbjct: 1578 RDAWNIFDFVTVLGSITDILVTEF---GNNFINLSFLRLFRAARLIKLLRQGYTIRILLW 1634
Query: 3712 TFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALD--------DSTSIHRNNNFHSFP 3867
TF++SF+ALPYV LLI +LFFIYA+IGMQ FG + +D D I +NNF +F
Sbjct: 1635 TFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDGEDEDSDEDEFQITEHNNFRTFF 1694
Query: 3868 AAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFF 4047
A+++LFRSATGEAW +IMLSC + CD S G+ + CGN FAY YF+SF
Sbjct: 1695 QALMLLFRSATGEAWHNIMLSCLSGKP--CDKNS------GIQKPECGNEFAYFYFVSFI 1746
Query: 4048 MLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTL 4227
LCSFL++NLFVAVIMDNF+YLTRD SILGPHHL+E+VR+W+EYDP A GRI + D+ +L
Sbjct: 1747 FLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAACGRIHYKDMYSL 1806
Query: 4228 LRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKI-YTEGNID 4404
LR ISPPLG GK CPHR+ACKRL+ M++P+ D TV FN+TL AL+RT L I +G D
Sbjct: 1807 LRVISPPLGLGKKCPHRVACKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGAD 1866
Query: 4405 --EANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKE 4578
+ + +LR + IW + LD +V P K D+TVGK YA +I +Y+R+ K K+
Sbjct: 1867 KQQMDAELRKEMMAIWPNLSQKTLDLLVTP-HKSTDLTVGKIYAAMMIMEYYRQ-SKAKK 1924
Query: 4579 MEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDEPEPQHRR-PHSLF 4755
++A +TP E GP S L+ E + P +
Sbjct: 1925 LQAMREEQNRTPLMFQRMEPPSPTQEGGPSQNALPSTQLDPGGGLMAQESSMKESPSWVT 1984
Query: 4756 NNLVHRLSGAGSKSPTEHERIEKGSTLLPFQPRSFSPTHSLAGAEG-------------- 4893
G+ SP I+ ++ QP S S G +G
Sbjct: 1985 QRAQEMFQKTGTWSPERGPPIDMPNS----QPNSQSVEMREMGTDGYSDSEHYLPMEGQT 2040
Query: 4894 -------SPVPSQMHRGAPINQSIN-LPPVNGSARRLPALPPYANHIHDET------DDG 5031
P +Q RG P +++ + + R L P A + D + ++
Sbjct: 2041 RAASMPRLPAENQRRRGRPRGNNLSTISDTSPMKRSASVLGPKARRLDDYSLERVPPEEN 2100
Query: 5032 PRY----RDTGDRAGYDQSSRMVVANRNLPVD----------PDEEEQWMRSGGPSNRSD 5169
RY RD G R R + L D P ++ R G P +R
Sbjct: 2101 QRYHQRRRDRGHRTSERSLGRYTDVDTGLGTDLSMTTQSGDLPSKDRDQDR-GRPKDRKH 2159
Query: 5170 RRNPH 5184
R + H
Sbjct: 2160 RPHHH 2164
Score = 533 bits (1372), Expect = e-149
Identities = 295/667 (44%), Positives = 382/667 (57%), Gaps = 27/667 (4%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N +RK I EW PFE++IL I ANCI LA+ Q P D + L+ E FI +
Sbjct: 86 DNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGI 145
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KIVA+GF FH +YLRN WN++DF++V+ G+++T+ ++ FD++ LRA R
Sbjct: 146 FCFEAGIKIVALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE-----FDLRTLRAVR 200
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQVVL +I++AMIPLL I LL+ F ILI+AIIGLE + GK H+TC +
Sbjct: 201 VLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFE 260
Query: 760 PATGQLAQKDPTPCGTD----TEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNF 927
T + + P PCGT+ T + KCQP W GPNNGIT F
Sbjct: 261 EGTDDIQGESPAPCGTEEPARTCPNGTKCQPY-----------------WEGPNNGITQF 303
Query: 928 DNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSG 1107
DN A+LTVFQC+++EGWTD++Y NDA G W W+YF+ L+I+GSFF+LNLVLGVLSG
Sbjct: 304 DNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSG 363
Query: 1108 EFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVAQTXXX 1287
EF+KERE+ R F K R +QQ+E +L GY++WI++AE++ + EDE + E
Sbjct: 364 EFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEV-ILAEDETDVEQRHPFDGA 422
Query: 1288 XXXXXXXXXXXXXXXP-----------------SKWAARMKRLE------KLNXXXXXXX 1398
P ++ + + +LE K
Sbjct: 423 LRRATLKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFYI 482
Query: 1399 XXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYS 1578
+VK+Q FYW HY Q EWL F A F+ LF EM +KMY
Sbjct: 483 RRMVKTQAFYWTVLSLVALNTLWLAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYG 542
Query: 1579 LGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXX 1758
LG Y S FN FDC V+I SI E + G+SVLR+ RLLRIFKVTKYW
Sbjct: 543 LGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASL 602
Query: 1759 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQAL 1938
GMQ+FGG+FNF+ + P NFDTF A+
Sbjct: 603 RNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFD--EGTPPTNFDTFPAAI 660
Query: 1939 LTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNL 2118
+TVFQILTGEDWN VMY I+S GGV G++ IY+IVL + GNY LLNVFLAIAVDNL
Sbjct: 661 MTVFQILTGEDWNEVMYDEIKSQGGVQG-GMVFSIYFIVLTLFGNYTLLNVFLAIAVDNL 719
Query: 2119 ADADSLT 2139
A+A LT
Sbjct: 720 ANAQELT 726
Score = 166 bits (421), Expect = 5e-39
Identities = 156/660 (23%), Positives = 273/660 (40%), Gaps = 29/660 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+R+LC I+ + FE IL +I + IALA P Q + +N +L +YVF VF
Sbjct: 1182 NPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDP--VQPNAPRNNVLRYFDYVFTGVF 1239
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD---VKALRA 573
T E V+K++ +G + H AY R+ WNILDFI+V LV+ + S +G D +K+LR
Sbjct: 1240 TFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNS-KGKDINTIKSLRV 1298
Query: 574 FRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTC 753
RVLRPL+ + +P L+ V + ++ ++ + +I ++ + + I+A++ ++LF GK C
Sbjct: 1299 LRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFH-C 1357
Query: 754 IDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDN 933
D + D G + + + W+ ++DN
Sbjct: 1358 TD---------ESKEFERDCRGK-YLLYEKNEVKARDREWKKYD-----------FHYDN 1396
Query: 934 FGLAMLTVFQCVSLEGWTDVMYWVNDAV---------GREWPWIYFVTLVILGSFFVLNL 1086
A+LT+F + EGW V+ DA R I++V ++ FF +N+
Sbjct: 1397 VLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNI 1456
Query: 1087 VLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEP 1266
+ ++ F ++ + K E+ LE++ + +D+ A+ +
Sbjct: 1457 FVALIIITFQEQGD---------KMMEEYSLEKNERACIDFAISAKPL------------ 1495
Query: 1267 VAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXX 1446
+ + + V S F +
Sbjct: 1496 -----------------------------TRHMPQNKQSFQYRMWQFVVSPPFEYTIMAM 1526
Query: 1447 XXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDC 1626
+ YG S ++ + N+ F LFS+E +LK+ + G Y +N FD
Sbjct: 1527 IALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDF 1586
Query: 1627 FVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXX 1806
V+ SI + ++ F + +S LR R R+ K+ +
Sbjct: 1587 VTVLGSITDILVTEFG-NNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPY 1645
Query: 1807 XXXXXXXXXXXXXXXGMQVFGG--------KFNFNPQQPKPRANFDTFVQALLTVFQILT 1962
GMQVFG + + Q NF TF QAL+ +F+ T
Sbjct: 1646 VCLLIAMLFFIYAIIGMQVFGNIGIDGEDEDSDEDEFQITEHNNFRTFFQALMLLFRSAT 1705
Query: 1963 GEDWNTVMYHGI-----ESFGGV--GTLGVIVCIYYIV--LFICGNYILLNVFLAIAVDN 2115
GE W+ +M + + G+ G +Y V +F+C ++++LN+F+A+ +DN
Sbjct: 1706 GEAWHNIMLSCLSGKPCDKNSGIQKPECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1764
Score = 121 bits (304), Expect = 2e-25
Identities = 74/274 (27%), Positives = 140/274 (51%), Gaps = 4/274 (1%)
Frame = +1
Query: 3313 RLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEA 3492
R+++ + V ++AF + + ++ +NT+ LA HY DFL IF G+F E
Sbjct: 477 RMRFYIRRMVKTQAFYWTVLSLVALNTLWLAIVHYNQPEWLSDFLYYAEFIFLGLFMSEM 536
Query: 3493 VLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVK 3672
+K+ L + Y +N FD V++GS ++ + + PG + I+ R R++R+ K
Sbjct: 537 FIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTS--FGISVLRALRLLRIFK 594
Query: 3673 LLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNN 3849
+ +R L+ + + S +++ + L+ L ++A++GMQ F G+ D+ T
Sbjct: 595 VTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTP---PT 651
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FPAAI+ +F+ TGE W ++M ++++ +GG+ G
Sbjct: 652 NFDTFPAAIMTVFQILTGEDWNEVMY-----DEIK--------SQGGVQ----GGMVFSI 694
Query: 4030 YFISFFMLCSFLVINLFVAVIMDNF---DYLTRD 4122
YFI + ++ ++N+F+A+ +DN LT+D
Sbjct: 695 YFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 728
Score = 95.9 bits (237), Expect = 1e-17
Identities = 73/296 (24%), Positives = 130/296 (43%), Gaps = 13/296 (4%)
Frame = +1
Query: 265 PFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFM 444
PFE+ I+ MI N I L + + Y+N L VF +F++ECVLK++A G +
Sbjct: 1518 PFEYTIMAMIALNTIVLMM--KFYGASVAYENAL-RVFNIVFTSLFSLECVLKVMAFGIL 1574
Query: 445 FHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQ 624
Y R+AWNI DF+ V+ + ++++ ++ LR FR R ++L+ +++
Sbjct: 1575 ----NYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIR 1630
Query: 625 VVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCG 804
++L +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1631 ILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF------------------------- 1665
Query: 805 TDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGW 984
N+G+ E + NF F A++ +F+ + E W
Sbjct: 1666 ----------------GNIGIDGEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAW 1709
Query: 985 TDVMYWV--------NDAV-----GREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
++M N + G E+ + YFV+ + L SF +LNL + V+ F
Sbjct: 1710 HNIMLSCLSGKPCDKNSGIQKPECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1765
Score = 86.3 bits (212), Expect = 8e-15
Identities = 69/263 (26%), Positives = 117/263 (44%), Gaps = 13/263 (4%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLF+ S N R + + F +L I+ + +LA E L + M L+
Sbjct: 79 SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 138
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSL-----TSFVLRTDAM 2667
+ +F +F E +K++ G FHKGS+ RN +N++D +VV + T F LRT
Sbjct: 139 EPYFIGIFCFEAGIKIVALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRT--- 195
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
++ L+ V++ ++ A+ + I L+ F +FAIIG++ +
Sbjct: 196 -----LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFY 250
Query: 2848 KGTFFL------CNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAM 3009
G F +D+ + A C E + TK +N FDN+ A+
Sbjct: 251 MGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAV 310
Query: 3010 ISLFVVSTFEGWPQLLYVAIDSN 3078
+++F T EGW LLY + D++
Sbjct: 311 LTVFQCITMEGWTDLLYNSNDAS 333
Score = 81.3 bits (199), Expect = 3e-13
Identities = 76/293 (25%), Positives = 123/293 (41%), Gaps = 43/293 (14%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY+I I+ N + LA + H P + LD F G+F FEA +KIVAL
Sbjct: 102 FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIVALGFAF 161
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WNV D +VV+ G L GT + R RV+R +KL+S
Sbjct: 162 HKGSYLRNGWNVMDFVVVL-------TGILATVGTE-FDLRTLRAVRVLRPLKLVSGIPS 213
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQF----FGKVALDDSTSIHR------ 3843
++ +L + MK+ L + LL+ I+A+IG++F F ++ T +
Sbjct: 214 LQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAP 273
Query: 3844 -----------------------NN---NFHSFPAAILVLFRSATGEAWQDIMLSCSDRE 3945
NN F + A+L +F+ T E W D++ + +D
Sbjct: 274 CGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDAS 333
Query: 3946 DVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
GN + + YFI ++ SF ++NL + V+ F
Sbjct: 334 ---------------------GNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 365
Score = 75.5 bits (184), Expect = 1e-11
Identities = 73/322 (22%), Positives = 139/322 (42%), Gaps = 16/322 (4%)
Frame = +1
Query: 250 IVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIV 429
+V+ + F + +L ++ N + LAI ++ + L E++F+ +F E +K+
Sbjct: 485 MVKTQAFYWTVLSLVALNTLWLAIVH---YNQPEWLSDFLYYAEFIFLGLFMSEMFIKMY 541
Query: 430 AMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKALRAFRVLRPLRLV 603
+G Y +++N D V+IG + ++ + G F + LRA R+LR ++
Sbjct: 542 GLG----TRPYFHSSFNCFD-CGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVT 596
Query: 604 SGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ 783
SL+ ++ ++L +M ++ + L+ I+++A++G++LF GQ
Sbjct: 597 KYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLF------------GGQFNF 644
Query: 784 KDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQ 963
+ TP TNFD F A++TVFQ
Sbjct: 645 DEGTPP---------------------------------------TNFDTFPAAIMTVFQ 665
Query: 964 CVSLEGWTDVMYWVNDAVGREWPW----IYFVTLVILGSFFVLNLVLGV----------L 1101
++ E W +VMY + G IYF+ L + G++ +LN+ L + L
Sbjct: 666 ILTGEDWNEVMYDEIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQEL 725
Query: 1102 SGEFSKEREKARARGLFQKFRE 1167
+ + +E E A + QK +E
Sbjct: 726 TKDEQEEEEAANQKLALQKAKE 747
Score = 47.0 bits (110), Expect = 0.005
Identities = 51/264 (19%), Positives = 103/264 (38%), Gaps = 3/264 (1%)
Frame = +1
Query: 2293 AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN 2472
A +++K +S F R + +V F VL + +++ LA Q
Sbjct: 456 ARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLWLAIVHYNQPE 515
Query: 2473 STRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL 2652
+ L Y ++ F +F E+ +K+ G + ++FN D V+ S+ +
Sbjct: 516 WLSDF-LYYAEFIFLGLFMSEMFIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIW 570
Query: 2653 RTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
K L+++V ++ ++K+I +++ + F+ +F
Sbjct: 571 AVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 630
Query: 2824 AIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGD 3003
A++G+QLF G F ++++G P NFD
Sbjct: 631 ALLGMQLFGGQF-------------------NFDEGTPPT-------------NFDTFPA 658
Query: 3004 AMISLFVVSTFEGWPQLLYVAIDS 3075
A++++F + T E W +++Y I S
Sbjct: 659 AIMTVFQILTGEDWNEVMYDEIKS 682
>gi|5802901|gb|AAD51822.1| N-type calcium channel alpha-1B cdB8
variant [Gallus gallus]
Length = 2157
Score = 679 bits (1753), Expect = 0.0
Identities = 357/766 (46%), Positives = 493/766 (63%), Gaps = 9/766 (1%)
Frame = +1
Query: 2308 KPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNM 2487
KPI SS+FILS TN R + +VN YF +L I +SS LAAEDP+QA S RN
Sbjct: 1117 KPILPYSSMFILSPTNPIRRLFHYIVNLRYFEMVILIVIALSSIALAAEDPVQAESPRND 1176
Query: 2488 ILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL---RT 2658
L Y DY FT VFT E+ +K+I GL+ H GS+ R+ +N+LD +VV+ +L +F +
Sbjct: 1177 ALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGSYFRDLWNILDFIVVSGALVAFAFSGTKG 1236
Query: 2659 DAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGV 2838
++ I R LK V CV+ ++K + NI++V + F+FA+I V
Sbjct: 1237 KDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAV 1296
Query: 2839 QLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISL 3018
QLFKG FF C D SK E +CRG+Y+ YE + ++ R W +F++DNV A+++L
Sbjct: 1297 QLFKGRFFYCTDESKELEKDCRGQYLDYEKNEVE---AQPREWKKYEFHYDNVLWALLTL 1353
Query: 3019 FVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIVT 3198
F VST EGWP +L ++D+ E++GP R +++ +I+T
Sbjct: 1354 FTVSTGEGWPTVLKHSVDATYEEQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIIT 1413
Query: 3199 FQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRAFEYVIF 3372
FQ +G++ C L+KN+R CI+FA+ AKP RY+P+N+ QY++W FV S FEY I
Sbjct: 1414 FQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNKQSFQYKMWKFVVSPPFEYFIM 1473
Query: 3373 LIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVF 3552
++I +NT+ L K Y + +E+ L N++FT +F+ E VLKI+A NY D WNVF
Sbjct: 1474 VMIALNTIVLMMKFYDAPEAYEEMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVF 1533
Query: 3553 DLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQ 3732
D + V+GS DI ++ N I+++F RLFR RL+KLL +G IR LLWTF++SF+
Sbjct: 1534 DFVTVLGSITDILVTEI-ADTDNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFK 1592
Query: 3733 ALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAW 3912
ALPYV LLI +LFFIYA+IGMQ FG +AL+D TSI+R+NNF +F A+++LFRSATGEAW
Sbjct: 1593 ALPYVCLLIAMLFFIYAIIGMQVFGNIALNDETSINRHNNFRTFLQALMLLFRSATGEAW 1652
Query: 3913 QDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVI 4092
+IMLSC CDP+S GL ++ CG++FAY YF+SF LCSFL++NLFVAVI
Sbjct: 1653 HEIMLSCLSNR--ACDPLS------GLTKNECGSDFAYFYFVSFIFLCSFLMLNLFVAVI 1704
Query: 4093 MDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCP 4272
MDNF+YLTRD SILGPHHL+EFVR+W+EYDP A RI + D+ LLR I+PPLG GK CP
Sbjct: 1705 MDNFEYLTRDSSILGPHHLDEFVRVWAEYDPAACCRIHYKDMYNLLRVIAPPLGLGKKCP 1764
Query: 4273 HRLACKRLVSMNMPLN-SDGTVCFNATLFALVRTNLKI-YTEGNI--DEANEQLRSAIKR 4440
HR+A KRLV MNMP++ D TV F +TL AL+RT L+I G + + + +LR I
Sbjct: 1765 HRVAYKRLVRMNMPISPEDLTVHFTSTLMALIRTALEIKLASGGVKQHQCDAELRKEISL 1824
Query: 4441 IWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKE 4578
+W + LD +VPP K D++TVGK YA +I D++++ K +E
Sbjct: 1825 VWPNLSQKTLDLLVPP-HKPDEMTVGKVYAALMIFDFYKQNKSSRE 1869
Score = 514 bits (1325), Expect = e-144
Identities = 291/668 (43%), Positives = 376/668 (55%), Gaps = 28/668 (4%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N IRK I EW PFE++IL I ANCI LA+ Q P D + L+ E FI +
Sbjct: 73 DNVIRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGI 132
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KI+A+GF+FH +YLRN WN++DF++V+ G+++T + FD++ LRA R
Sbjct: 133 FCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTD-----FDLRTLRAVR 187
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQVVL +I++AM+PLL I LL+ F I+++AIIGLE + GK H TC
Sbjct: 188 VLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAIVMFAIIGLEFYMGKFHKTCFS 247
Query: 760 PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTT----WPGPNNGITNF 927
TG+ + PCG + +C S TT W GPN GITNF
Sbjct: 248 NKTGE--EVGDFPCGEEPPAR-----------------QCESGTTCREYWQGPNYGITNF 288
Query: 928 DNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSG 1107
DN A+LTVFQC+++EGWTD++Y NDA G W W+YF+ L+I+GSFF+LNLVLGVLSG
Sbjct: 289 DNILFAVLTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSG 348
Query: 1108 EFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDE--QEDEPVAQTX 1281
EF+KERE+ R F K R +QQ+E +L GYL+WI +AE++ ED+ +E P+
Sbjct: 349 EFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDKNAEEKSPLDMLK 408
Query: 1282 XXX----------------------XXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXX 1395
++ ++ +R EK+
Sbjct: 409 RAAIKKSKNDLIHAEEGEDHFTDICSVGSPFARASLKSGKNESSSYFRRKEKM---FRFF 465
Query: 1396 XXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMY 1575
+VK+Q+FYW HY Q E L A F+ LF EM LKMY
Sbjct: 466 IRRMVKAQSFYWIVLCVVALNTLCVAMVHYDQPEKLTTALYFAEFVFLGLFLTEMSLKMY 525
Query: 1576 SLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTX 1755
LG Y S FN FD V++ SI E + G+SVLR+ RLLRIFKVTKYW
Sbjct: 526 GLGPRNYFHSSFNYFDFGVIVGSIFEVIWAAVKPGTSFGISVLRALRLLRIFKVTKYWNS 585
Query: 1756 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQA 1935
GMQ+FGG+FNF + P NFDTF A
Sbjct: 586 LRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFRDE--TPTTNFDTFPAA 643
Query: 1936 LLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDN 2115
+LTVFQILTGEDWN VMYHGIES GGV + G+ IY+IVL + GNY LLNVFLAIAVDN
Sbjct: 644 ILTVFQILTGEDWNAVMYHGIESQGGVHS-GMFSSIYFIVLTLFGNYTLLNVFLAIAVDN 702
Query: 2116 LADADSLT 2139
LA+A LT
Sbjct: 703 LANAQELT 710
Score = 177 bits (448), Expect = 3e-42
Identities = 158/651 (24%), Positives = 276/651 (42%), Gaps = 20/651 (3%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR+L IV + FE +IL +I + IALA P A+ +N L+ ++Y+F VF
Sbjct: 1132 NPIRRLFHYIVNLRYFEMVILIVIALSSIALAAEDPVQAESP--RNDALKYLDYIFTGVF 1189
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD-VKALRAFR 579
T E V+K++ +G + HP +Y R+ WNILDFI+V LV+ S + + +K+LR R
Sbjct: 1190 TFEMVIKMIDLGLLLHPGSYFRDLWNILDFIVVSGALVAFAFSGTKGKDINTIKSLRVLR 1249
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF G+ C D
Sbjct: 1250 VLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGRFFY-CTD 1308
Query: 760 PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFG 939
+ + +KD D E + + QP + W+ ++DN
Sbjct: 1309 ES--KELEKDCRGQYLDYEKNEVEAQPRE--------WKKYE-----------FHYDNVL 1347
Query: 940 LAMLTVFQCVSLEGWTDVMYWVNDAVGREWP---------WIYFVTLVILGSFFVLNLVL 1092
A+LT+F + EGW V+ DA E I++V ++ FF +N+ +
Sbjct: 1348 WALLTLFTVSTGEGWPTVLKHSVDATYEEQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFV 1407
Query: 1093 GVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVA 1272
++ F ++ + K + LE++ + +D+ A+ +
Sbjct: 1408 ALIIITFQEQGD---------KVMSECSLEKNERACIDFAISAKPL-------------- 1444
Query: 1273 QTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXX 1452
P + ++ K V S F +
Sbjct: 1445 ----------------TRYMPQNKQSFQYKMWKF-----------VVSPPFEYFIMVMIA 1477
Query: 1453 XXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFV 1632
+ Y E + N+ F +FSME +LK+ + G Y +N FD
Sbjct: 1478 LNTIVLMMKFYDAPEAYEEMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVT 1537
Query: 1633 VISSILEFVLVYF-DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXX 1809
V+ SI + ++ D + +S LR R R+ K+ +
Sbjct: 1538 VLGSITDILVTEIADTDNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV 1597
Query: 1810 XXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMY 1989
GMQVFG + NF TF+QAL+ +F+ TGE W+ +M
Sbjct: 1598 CLLIAMLFFIYAIIGMQVFGNIALNDETSINRHNNFRTFLQALMLLFRSATGEAWHEIML 1657
Query: 1990 -----HGIESFGGV--GTLGVIVCIYYIV--LFICGNYILLNVFLAIAVDN 2115
+ G+ G +Y V +F+C ++++LN+F+A+ +DN
Sbjct: 1658 SCLSNRACDPLSGLTKNECGSDFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1707
Score = 122 bits (306), Expect = 1e-25
Identities = 81/293 (27%), Positives = 141/293 (47%), Gaps = 8/293 (2%)
Frame = +1
Query: 3268 FALKAKPHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFL 3447
F K K R +I R V +++F +++ ++ +NT+ +A HY L
Sbjct: 455 FRRKEKMFRFFIRR---------MVKAQSFYWIVLCVVALNTLCVAMVHYDQPEKLTTAL 505
Query: 3448 DVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLI 3627
+F G+F E LK+ L P+NY +N FD V+VGS ++ + + PG +
Sbjct: 506 YFAEFVFLGLFLTEMSLKMYGLGPRNYFHSSFNYFDFGVIVGSIFEVIWAAVKPGTS--F 563
Query: 3628 SINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF- 3804
I+ R R++R+ K+ +R L+ + + S +++ + L+ L ++A++GMQ F
Sbjct: 564 GISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFG 623
Query: 3805 GKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYH- 3981
G+ D T NF +FPAAIL +F+ TGE W +M YH
Sbjct: 624 GQFNFRDETP---TTNFDTFPAAILTVFQILTGEDWNAVM-----------------YHG 663
Query: 3982 ---KGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF---DYLTRD 4122
+GG++ F+ YFI + ++ ++N+F+A+ +DN LT+D
Sbjct: 664 IESQGGVHSGM----FSSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 712
Score = 95.9 bits (237), Expect = 1e-17
Identities = 77/316 (24%), Positives = 139/316 (43%), Gaps = 20/316 (6%)
Frame = +1
Query: 226 PIRKLCISIVEWK-----PFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVF 390
P K WK PFE+ I+ MI N I L + + Y A ++ +L+ + VF
Sbjct: 1449 PQNKQSFQYKMWKFVVSPPFEYFIMVMIALNTIVLMM-KFYDAPEA--YEEMLKCLNIVF 1505
Query: 391 IVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKA 564
+F++ECVLKI+A G + Y R+AWN+ DF+ V+ + ++++++ ++
Sbjct: 1506 TSMFSMECVLKIIAFGVL----NYFRDAWNVFDFVTVLGSITDILVTEIADTDNFINLSF 1561
Query: 565 LRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLH 744
LR FR R ++L+ +++++L +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1562 LRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF----- 1616
Query: 745 STCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITN 924
G +A D T N N
Sbjct: 1617 --------GNIALNDETSI------------------------------------NRHNN 1632
Query: 925 FDNFGLAMLTVFQCVSLEGWTDVMY-------------WVNDAVGREWPWIYFVTLVILG 1065
F F A++ +F+ + E W ++M + G ++ + YFV+ + L
Sbjct: 1633 FRTFLQALMLLFRSATGEAWHEIMLSCLSNRACDPLSGLTKNECGSDFAYFYFVSFIFLC 1692
Query: 1066 SFFVLNLVLGVLSGEF 1113
SF +LNL + V+ F
Sbjct: 1693 SFLMLNLFVAVIMDNF 1708
Score = 88.2 bits (217), Expect = 2e-15
Identities = 73/263 (27%), Positives = 119/263 (44%), Gaps = 14/263 (5%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLFI S N R + + F +L I+ + +LA E L M L+
Sbjct: 66 SLFIFSEDNVIRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 125
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV-----AVSLTSFVLRTDAM 2667
+ +F +F E +K+I G VFHKGS+ RN +N++D +VV A + T F LRT
Sbjct: 126 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDFDLRT--- 182
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
++ L+ V++ ++ A+ + I L+ F MFAIIG++ +
Sbjct: 183 -----LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAIVMFAIIGLEFY 237
Query: 2848 KGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSK----KRVWSNNDF---NFDNVGDA 3006
G F +K E G++ E+ P + + W ++ NFDN+ A
Sbjct: 238 MGKFHKTCFSNKTGEEV--GDFPCGEE-PPARQCESGTTCREYWQGPNYGITNFDNILFA 294
Query: 3007 MISLFVVSTFEGWPQLLYVAIDS 3075
++++F T EGW +LY D+
Sbjct: 295 VLTVFQCITMEGWTDILYNTNDA 317
Score = 85.9 bits (211), Expect = 1e-14
Identities = 75/291 (25%), Positives = 123/291 (41%), Gaps = 41/291 (14%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY+I I+ N + LA + H P + LD F G+F FEA +KI+AL
Sbjct: 89 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 148
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WNV D +VV+ G L GT+ + R RV+R +KL+S
Sbjct: 149 HKGSYLRNGWNVMDFVVVL-------TGILATAGTD-FDLRTLRAVRVLRPLKLVSGIPS 200
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQF----FGKVALDDSTSIHRNN---- 3849
++ +L + MK+ L + LL+ ++A+IG++F F K + T +
Sbjct: 201 LQVVLKSIMKAMVPLLQIGLLLFFAIVMFAIIGLEFYMGKFHKTCFSNKTGEEVGDFPCG 260
Query: 3850 --------------------------NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDV 3951
NF + A+L +F+ T E W DI+ + +D
Sbjct: 261 EEPPARQCESGTTCREYWQGPNYGITNFDNILFAVLTVFQCITMEGWTDILYNTND---- 316
Query: 3952 RCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
GN + + YFI ++ SF ++NL + V+ F
Sbjct: 317 -----------------AAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 350
Score = 53.5 bits (127), Expect = 6e-05
Identities = 55/274 (20%), Positives = 108/274 (39%), Gaps = 3/274 (1%)
Frame = +1
Query: 2293 AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN 2472
A +++K SS + FR F +V F VL C++ + + A
Sbjct: 440 ARASLKSGKNESSSYFRRKEKMFRFFIRRMVKAQSFYWIVL-CVVALNTLCVAMVHYDQP 498
Query: 2473 STRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL 2652
L + ++ F +F E++LK+ G ++ ++FN D V+ S+ +
Sbjct: 499 EKLTTALYFAEFVFLGLFLTEMSLKMYGLG----PRNYFHSSFNYFDFGVIVGSIFEVIW 554
Query: 2653 RTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
K L+++V ++ ++K+I +++ + F+ +F
Sbjct: 555 AAVKPGTSFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVF 614
Query: 2824 AIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGD 3003
A++G+QLF G F ++ D PT NFD
Sbjct: 615 ALLGMQLFGGQF-------------------NFRDETPTT-------------NFDTFPA 642
Query: 3004 AMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHN 3105
A++++F + T E W ++Y I+S +G +H+
Sbjct: 643 AILTVFQILTGEDWNAVMYHGIES----QGGVHS 672
>gi|5802891|gb|AAD51817.1| N-type calcium channel alpha-1B cdB3
variant [Gallus gallus]
Length = 2321
Score = 679 bits (1753), Expect = 0.0
Identities = 357/766 (46%), Positives = 493/766 (63%), Gaps = 9/766 (1%)
Frame = +1
Query: 2308 KPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNM 2487
KPI SS+FILS TN R + +VN YF +L I +SS LAAEDP+QA S RN
Sbjct: 1106 KPILPYSSMFILSPTNPIRRLFHYIVNLRYFEMVILIVIALSSIALAAEDPVQAESPRND 1165
Query: 2488 ILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL---RT 2658
L Y DY FT VFT E+ +K+I GL+ H GS+ R+ +N+LD +VV+ +L +F +
Sbjct: 1166 ALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGSYFRDLWNILDFIVVSGALVAFAFSGTKG 1225
Query: 2659 DAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGV 2838
++ I R LK V CV+ ++K + NI++V + F+FA+I V
Sbjct: 1226 KDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAV 1285
Query: 2839 QLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISL 3018
QLFKG FF C D SK E +CRG+Y+ YE + ++ R W +F++DNV A+++L
Sbjct: 1286 QLFKGRFFYCTDESKELEKDCRGQYLDYEKNEVE---AQPREWKKYEFHYDNVLWALLTL 1342
Query: 3019 FVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIVT 3198
F VST EGWP +L ++D+ E++GP R +++ +I+T
Sbjct: 1343 FTVSTGEGWPTVLKHSVDATYEEQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIIT 1402
Query: 3199 FQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRAFEYVIF 3372
FQ +G++ C L+KN+R CI+FA+ AKP RY+P+N+ QY++W FV S FEY I
Sbjct: 1403 FQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNKQSFQYKMWKFVVSPPFEYFIM 1462
Query: 3373 LIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVF 3552
++I +NT+ L K Y + +E+ L N++FT +F+ E VLKI+A NY D WNVF
Sbjct: 1463 VMIALNTIVLMMKFYDAPEAYEEMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVF 1522
Query: 3553 DLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQ 3732
D + V+GS DI ++ N I+++F RLFR RL+KLL +G IR LLWTF++SF+
Sbjct: 1523 DFVTVLGSITDILVTEI-ADTDNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFK 1581
Query: 3733 ALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAW 3912
ALPYV LLI +LFFIYA+IGMQ FG +AL+D TSI+R+NNF +F A+++LFRSATGEAW
Sbjct: 1582 ALPYVCLLIAMLFFIYAIIGMQVFGNIALNDETSINRHNNFRTFLQALMLLFRSATGEAW 1641
Query: 3913 QDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVI 4092
+IMLSC CDP+S GL ++ CG++FAY YF+SF LCSFL++NLFVAVI
Sbjct: 1642 HEIMLSCLSNR--ACDPLS------GLTKNECGSDFAYFYFVSFIFLCSFLMLNLFVAVI 1693
Query: 4093 MDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCP 4272
MDNF+YLTRD SILGPHHL+EFVR+W+EYDP A RI + D+ LLR I+PPLG GK CP
Sbjct: 1694 MDNFEYLTRDSSILGPHHLDEFVRVWAEYDPAACCRIHYKDMYNLLRVIAPPLGLGKKCP 1753
Query: 4273 HRLACKRLVSMNMPLN-SDGTVCFNATLFALVRTNLKI-YTEGNI--DEANEQLRSAIKR 4440
HR+A KRLV MNMP++ D TV F +TL AL+RT L+I G + + + +LR I
Sbjct: 1754 HRVAYKRLVRMNMPISPEDLTVHFTSTLMALIRTALEIKLASGGVKQHQCDAELRKEISL 1813
Query: 4441 IWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKE 4578
+W + LD +VPP K D++TVGK YA +I D++++ K +E
Sbjct: 1814 VWPNLSQKTLDLLVPP-HKPDEMTVGKVYAALMIFDFYKQNKSSRE 1858
Score = 519 bits (1336), Expect = e-145
Identities = 291/657 (44%), Positives = 376/657 (56%), Gaps = 17/657 (2%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N IRK I EW PFE++IL I ANCI LA+ Q P D + L+ E FI +
Sbjct: 73 DNVIRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGI 132
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KI+A+GF+FH +YLRN WN++DF++V+ G+++T + FD++ LRA R
Sbjct: 133 FCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTD-----FDLRTLRAVR 187
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQVVL +I++AM+PLL I LL+ F I+++AIIGLE + GK H TC
Sbjct: 188 VLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAIVMFAIIGLEFYMGKFHKTCFS 247
Query: 760 PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTT----WPGPNNGITNF 927
TG+ + PCG + +C S TT W GPN GITNF
Sbjct: 248 NKTGE--EVGDFPCGEEPPAR-----------------QCESGTTCREYWQGPNYGITNF 288
Query: 928 DNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSG 1107
DN A+LTVFQC+++EGWTD++Y NDA G W W+YF+ L+I+GSFF+LNLVLGVLSG
Sbjct: 289 DNILFAVLTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSG 348
Query: 1108 EFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDE--QEDEPVAQTX 1281
EF+KERE+ R F K R +QQ+E +L GYL+WI +AE++ ED+ +E P+
Sbjct: 349 EFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDKNAEEKSPLDMLK 408
Query: 1282 XXXXXXXX-----------XXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFY 1428
++ ++ +R EK+ +VK+Q+FY
Sbjct: 409 RAAIKKSKNDLIHAEEGSPFARASLKSGKNESSSYFRRKEKM---FRFFIRRMVKAQSFY 465
Query: 1429 WXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQ 1608
W HY Q E L A F+ LF EM LKMY LG Y S
Sbjct: 466 WIVLCVVALNTLCVAMVHYDQPEKLTTALYFAEFVFLGLFLTEMSLKMYGLGPRNYFHSS 525
Query: 1609 FNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXX 1788
FN FD V++ SI E + G+SVLR+ RLLRIFKVTKYW
Sbjct: 526 FNYFDFGVIVGSIFEVIWAAVKPGTSFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNS 585
Query: 1789 XXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGE 1968
GMQ+FGG+FNF + P NFDTF A+LTVFQILTGE
Sbjct: 586 MKSIISLLFLLFLFIVVFALLGMQLFGGQFNFRDE--TPTTNFDTFPAAILTVFQILTGE 643
Query: 1969 DWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLT 2139
DWN VMYHGIES GGV + G+ IY+IVL + GNY LLNVFLAIAVDNLA+A LT
Sbjct: 644 DWNAVMYHGIESQGGVHS-GMFSSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELT 699
Score = 177 bits (448), Expect = 3e-42
Identities = 163/672 (24%), Positives = 280/672 (41%), Gaps = 74/672 (11%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLFI S N R + + F +L I+ + +LA E L M L+
Sbjct: 66 SLFIFSEDNVIRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 125
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSL-----TSFVLRTDAM 2667
+ +F +F E +K+I G VFHKGS+ RN +N++D +VV + T F LRT
Sbjct: 126 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDFDLRT--- 182
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
++ L+ V++ ++ A+ + I L+ F MFAIIG++ +
Sbjct: 183 -----LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAIVMFAIIGLEFY 237
Query: 2848 KGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSK---KRVWSNNDF---NFDNVGDAM 3009
G F +K E G++ E+ + S + W ++ NFDN+ A+
Sbjct: 238 MGKFHKTCFSNKTGEEV--GDFPCGEEPPARQCESGTTCREYWQGPNYGITNFDNILFAV 295
Query: 3010 ISLFVVSTFEGWPQL------------------------------LYVAIDSNE--EDKG 3093
+++F T EGW + L + + S E +++
Sbjct: 296 LTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERE 355
Query: 3094 PIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIE-- 3267
+ N R + L V E + E LD +R I+
Sbjct: 356 RVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDKNAEEKSPLDMLKRAAIKKS 415
Query: 3268 -----FALKAKPHRR------------YIPRNRLQYRVWW--FVTSRAFEYVIFLIIVMN 3390
A + P R Y R +R + V +++F +++ ++ +N
Sbjct: 416 KNDLIHAEEGSPFARASLKSGKNESSSYFRRKEKMFRFFIRRMVKAQSFYWIVLCVVALN 475
Query: 3391 TVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVV 3570
T+ +A HY L +F G+F E LK+ L P+NY +N FD V+V
Sbjct: 476 TLCVAMVHYDQPEKLTTALYFAEFVFLGLFLTEMSLKMYGLGPRNYFHSSFNYFDFGVIV 535
Query: 3571 GSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVA 3750
GS ++ + + PG + I+ R R++R+ K+ +R L+ + + S +++ +
Sbjct: 536 GSIFEVIWAAVKPGTS--FGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLL 593
Query: 3751 LLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIML 3927
L+ L ++A++GMQ F G+ D T NF +FPAAIL +F+ TGE W +M
Sbjct: 594 FLLFLFIVVFALLGMQLFGGQFNFRDETP---TTNFDTFPAAILTVFQILTGEDWNAVM- 649
Query: 3928 SCSDREDVRCDPMSDDYH----KGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIM 4095
YH +GG++ F+ YFI + ++ ++N+F+A+ +
Sbjct: 650 ----------------YHGIESQGGVHSGM----FSSIYFIVLTLFGNYTLLNVFLAIAV 689
Query: 4096 DNF---DYLTRD 4122
DN LT+D
Sbjct: 690 DNLANAQELTKD 701
Score = 177 bits (448), Expect = 3e-42
Identities = 158/651 (24%), Positives = 276/651 (42%), Gaps = 20/651 (3%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR+L IV + FE +IL +I + IALA P A+ +N L+ ++Y+F VF
Sbjct: 1121 NPIRRLFHYIVNLRYFEMVILIVIALSSIALAAEDPVQAESP--RNDALKYLDYIFTGVF 1178
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD-VKALRAFR 579
T E V+K++ +G + HP +Y R+ WNILDFI+V LV+ S + + +K+LR R
Sbjct: 1179 TFEMVIKMIDLGLLLHPGSYFRDLWNILDFIVVSGALVAFAFSGTKGKDINTIKSLRVLR 1238
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF G+ C D
Sbjct: 1239 VLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGRFFY-CTD 1297
Query: 760 PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFG 939
+ + +KD D E + + QP + W+ ++DN
Sbjct: 1298 ES--KELEKDCRGQYLDYEKNEVEAQPRE--------WKKYE-----------FHYDNVL 1336
Query: 940 LAMLTVFQCVSLEGWTDVMYWVNDAVGREWP---------WIYFVTLVILGSFFVLNLVL 1092
A+LT+F + EGW V+ DA E I++V ++ FF +N+ +
Sbjct: 1337 WALLTLFTVSTGEGWPTVLKHSVDATYEEQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFV 1396
Query: 1093 GVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVA 1272
++ F ++ + K + LE++ + +D+ A+ +
Sbjct: 1397 ALIIITFQEQGD---------KVMSECSLEKNERACIDFAISAKPL-------------- 1433
Query: 1273 QTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXX 1452
P + ++ K V S F +
Sbjct: 1434 ----------------TRYMPQNKQSFQYKMWKF-----------VVSPPFEYFIMVMIA 1466
Query: 1453 XXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFV 1632
+ Y E + N+ F +FSME +LK+ + G Y +N FD
Sbjct: 1467 LNTIVLMMKFYDAPEAYEEMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVT 1526
Query: 1633 VISSILEFVLVYF-DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXX 1809
V+ SI + ++ D + +S LR R R+ K+ +
Sbjct: 1527 VLGSITDILVTEIADTDNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV 1586
Query: 1810 XXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMY 1989
GMQVFG + NF TF+QAL+ +F+ TGE W+ +M
Sbjct: 1587 CLLIAMLFFIYAIIGMQVFGNIALNDETSINRHNNFRTFLQALMLLFRSATGEAWHEIML 1646
Query: 1990 -----HGIESFGGV--GTLGVIVCIYYIV--LFICGNYILLNVFLAIAVDN 2115
+ G+ G +Y V +F+C ++++LN+F+A+ +DN
Sbjct: 1647 SCLSNRACDPLSGLTKNECGSDFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1696
Score = 95.9 bits (237), Expect = 1e-17
Identities = 77/316 (24%), Positives = 139/316 (43%), Gaps = 20/316 (6%)
Frame = +1
Query: 226 PIRKLCISIVEWK-----PFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVF 390
P K WK PFE+ I+ MI N I L + + Y A ++ +L+ + VF
Sbjct: 1438 PQNKQSFQYKMWKFVVSPPFEYFIMVMIALNTIVLMM-KFYDAPEA--YEEMLKCLNIVF 1494
Query: 391 IVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKA 564
+F++ECVLKI+A G + Y R+AWN+ DF+ V+ + ++++++ ++
Sbjct: 1495 TSMFSMECVLKIIAFGVL----NYFRDAWNVFDFVTVLGSITDILVTEIADTDNFINLSF 1550
Query: 565 LRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLH 744
LR FR R ++L+ +++++L +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1551 LRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF----- 1605
Query: 745 STCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITN 924
G +A D T N N
Sbjct: 1606 --------GNIALNDETSI------------------------------------NRHNN 1621
Query: 925 FDNFGLAMLTVFQCVSLEGWTDVMY-------------WVNDAVGREWPWIYFVTLVILG 1065
F F A++ +F+ + E W ++M + G ++ + YFV+ + L
Sbjct: 1622 FRTFLQALMLLFRSATGEAWHEIMLSCLSNRACDPLSGLTKNECGSDFAYFYFVSFIFLC 1681
Query: 1066 SFFVLNLVLGVLSGEF 1113
SF +LNL + V+ F
Sbjct: 1682 SFLMLNLFVAVIMDNF 1697
Score = 53.5 bits (127), Expect = 6e-05
Identities = 55/274 (20%), Positives = 108/274 (39%), Gaps = 3/274 (1%)
Frame = +1
Query: 2293 AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN 2472
A +++K SS + FR F +V F VL C++ + + A
Sbjct: 429 ARASLKSGKNESSSYFRRKEKMFRFFIRRMVKAQSFYWIVL-CVVALNTLCVAMVHYDQP 487
Query: 2473 STRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL 2652
L + ++ F +F E++LK+ G ++ ++FN D V+ S+ +
Sbjct: 488 EKLTTALYFAEFVFLGLFLTEMSLKMYGLG----PRNYFHSSFNYFDFGVIVGSIFEVIW 543
Query: 2653 RTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
K L+++V ++ ++K+I +++ + F+ +F
Sbjct: 544 AAVKPGTSFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVF 603
Query: 2824 AIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGD 3003
A++G+QLF G F ++ D PT NFD
Sbjct: 604 ALLGMQLFGGQF-------------------NFRDETPTT-------------NFDTFPA 631
Query: 3004 AMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHN 3105
A++++F + T E W ++Y I+S +G +H+
Sbjct: 632 AILTVFQILTGEDWNAVMYHGIES----QGGVHS 661
>gi|5802889|gb|AAD51816.1| N-type calcium channel alpha-1B cdB2
variant [Gallus gallus]
Length = 2182
Score = 679 bits (1753), Expect = 0.0
Identities = 357/766 (46%), Positives = 493/766 (63%), Gaps = 9/766 (1%)
Frame = +1
Query: 2308 KPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNM 2487
KPI SS+FILS TN R + +VN YF +L I +SS LAAEDP+QA S RN
Sbjct: 1142 KPILPYSSMFILSPTNPIRRLFHYIVNLRYFEMVILIVIALSSIALAAEDPVQAESPRND 1201
Query: 2488 ILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL---RT 2658
L Y DY FT VFT E+ +K+I GL+ H GS+ R+ +N+LD +VV+ +L +F +
Sbjct: 1202 ALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGSYFRDLWNILDFIVVSGALVAFAFSGTKG 1261
Query: 2659 DAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGV 2838
++ I R LK V CV+ ++K + NI++V + F+FA+I V
Sbjct: 1262 KDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAV 1321
Query: 2839 QLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISL 3018
QLFKG FF C D SK E +CRG+Y+ YE + ++ R W +F++DNV A+++L
Sbjct: 1322 QLFKGRFFYCTDESKELEKDCRGQYLDYEKNEVE---AQPREWKKYEFHYDNVLWALLTL 1378
Query: 3019 FVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIVT 3198
F VST EGWP +L ++D+ E++GP R +++ +I+T
Sbjct: 1379 FTVSTGEGWPTVLKHSVDATYEEQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIIT 1438
Query: 3199 FQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRAFEYVIF 3372
FQ +G++ C L+KN+R CI+FA+ AKP RY+P+N+ QY++W FV S FEY I
Sbjct: 1439 FQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNKQSFQYKMWKFVVSPPFEYFIM 1498
Query: 3373 LIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVF 3552
++I +NT+ L K Y + +E+ L N++FT +F+ E VLKI+A NY D WNVF
Sbjct: 1499 VMIALNTIVLMMKFYDAPEAYEEMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVF 1558
Query: 3553 DLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQ 3732
D + V+GS DI ++ N I+++F RLFR RL+KLL +G IR LLWTF++SF+
Sbjct: 1559 DFVTVLGSITDILVTEI-ADTDNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFK 1617
Query: 3733 ALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAW 3912
ALPYV LLI +LFFIYA+IGMQ FG +AL+D TSI+R+NNF +F A+++LFRSATGEAW
Sbjct: 1618 ALPYVCLLIAMLFFIYAIIGMQVFGNIALNDETSINRHNNFRTFLQALMLLFRSATGEAW 1677
Query: 3913 QDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVI 4092
+IMLSC CDP+S GL ++ CG++FAY YF+SF LCSFL++NLFVAVI
Sbjct: 1678 HEIMLSCLSNR--ACDPLS------GLTKNECGSDFAYFYFVSFIFLCSFLMLNLFVAVI 1729
Query: 4093 MDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCP 4272
MDNF+YLTRD SILGPHHL+EFVR+W+EYDP A RI + D+ LLR I+PPLG GK CP
Sbjct: 1730 MDNFEYLTRDSSILGPHHLDEFVRVWAEYDPAACCRIHYKDMYNLLRVIAPPLGLGKKCP 1789
Query: 4273 HRLACKRLVSMNMPLN-SDGTVCFNATLFALVRTNLKI-YTEGNI--DEANEQLRSAIKR 4440
HR+A KRLV MNMP++ D TV F +TL AL+RT L+I G + + + +LR I
Sbjct: 1790 HRVAYKRLVRMNMPISPEDLTVHFTSTLMALIRTALEIKLASGGVKQHQCDAELRKEISL 1849
Query: 4441 IWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKE 4578
+W + LD +VPP K D++TVGK YA +I D++++ K +E
Sbjct: 1850 VWPNLSQKTLDLLVPP-HKPDEMTVGKVYAALMIFDFYKQNKSSRE 1894
Score = 503 bits (1294), Expect = e-140
Identities = 290/693 (41%), Positives = 375/693 (53%), Gaps = 53/693 (7%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N IRK I EW PFE++IL I ANCI LA+ Q P D + L+ E FI +
Sbjct: 73 DNVIRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGI 132
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KI+A+GF+FH +YLRN WN++DF++V+ G+++T + FD++ LRA R
Sbjct: 133 FCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTD-----FDLRTLRAVR 187
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQVVL +I++AM+PLL I LL+ F I+++AIIGLE + GK H TC
Sbjct: 188 VLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAIVMFAIIGLEFYMGKFHKTCFS 247
Query: 760 PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTT----WPGPNNGITNF 927
TG+ + PCG + +C S TT W GPN GITNF
Sbjct: 248 NKTGE--EVGDFPCGEEPPAR-----------------QCESGTTCREYWQGPNYGITNF 288
Query: 928 DNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSG 1107
DN A+LTVFQC+++EGWTD++Y NDA G W W+YF+ L+I+GSFF+LNLVLGVLSG
Sbjct: 289 DNILFAVLTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSG 348
Query: 1108 EFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQ------------AEDIEPVNEDE 1251
EF+KERE+ R F K R +QQ+E +L GYL+WI + AE+ P++
Sbjct: 349 EFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDKNAEEKSPLDGRA 408
Query: 1252 QEDEPVAQTXXXXXXXXXXXX-------------------------------------XX 1320
+ P+ Q
Sbjct: 409 ASEGPIQQGTAPAETSSGSSYNMLKRAAIKKSKNDLIHAEEGEDHFTDICSVGSPFARAS 468
Query: 1321 XXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEW 1500
++ ++ +R EK+ +VK+Q+FYW HY Q E
Sbjct: 469 LKSGKNESSSYFRRKEKM---FRFFIRRMVKAQSFYWIVLCVVALNTLCVAMVHYDQPEK 525
Query: 1501 LDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLM 1680
L A F+ LF EM LKMY LG Y S FN FD V++ SI E +
Sbjct: 526 LTTALYFAEFVFLGLFLTEMSLKMYGLGPRNYFHSSFNYFDFGVIVGSIFEVIWAAVKPG 585
Query: 1681 KPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQ 1860
G+SVLR+ RLLRIFKVTKYW GMQ
Sbjct: 586 TSFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQ 645
Query: 1861 VFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVC 2040
+FGG+FNF + P NFDTF A+LTVFQILTGEDWN VMYHGIES GGV + G+
Sbjct: 646 LFGGQFNFRDE--TPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVHS-GMFSS 702
Query: 2041 IYYIVLFICGNYILLNVFLAIAVDNLADADSLT 2139
IY+IVL + GNY LLNVFLAIAVDNLA+A LT
Sbjct: 703 IYFIVLTLFGNYTLLNVFLAIAVDNLANAQELT 735
Score = 177 bits (448), Expect = 3e-42
Identities = 158/651 (24%), Positives = 276/651 (42%), Gaps = 20/651 (3%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR+L IV + FE +IL +I + IALA P A+ +N L+ ++Y+F VF
Sbjct: 1157 NPIRRLFHYIVNLRYFEMVILIVIALSSIALAAEDPVQAESP--RNDALKYLDYIFTGVF 1214
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD-VKALRAFR 579
T E V+K++ +G + HP +Y R+ WNILDFI+V LV+ S + + +K+LR R
Sbjct: 1215 TFEMVIKMIDLGLLLHPGSYFRDLWNILDFIVVSGALVAFAFSGTKGKDINTIKSLRVLR 1274
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF G+ C D
Sbjct: 1275 VLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGRFFY-CTD 1333
Query: 760 PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFG 939
+ + +KD D E + + QP + W+ ++DN
Sbjct: 1334 ES--KELEKDCRGQYLDYEKNEVEAQPRE--------WKKYE-----------FHYDNVL 1372
Query: 940 LAMLTVFQCVSLEGWTDVMYWVNDAVGREWP---------WIYFVTLVILGSFFVLNLVL 1092
A+LT+F + EGW V+ DA E I++V ++ FF +N+ +
Sbjct: 1373 WALLTLFTVSTGEGWPTVLKHSVDATYEEQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFV 1432
Query: 1093 GVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVA 1272
++ F ++ + K + LE++ + +D+ A+ +
Sbjct: 1433 ALIIITFQEQGD---------KVMSECSLEKNERACIDFAISAKPL-------------- 1469
Query: 1273 QTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXX 1452
P + ++ K V S F +
Sbjct: 1470 ----------------TRYMPQNKQSFQYKMWKF-----------VVSPPFEYFIMVMIA 1502
Query: 1453 XXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFV 1632
+ Y E + N+ F +FSME +LK+ + G Y +N FD
Sbjct: 1503 LNTIVLMMKFYDAPEAYEEMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVT 1562
Query: 1633 VISSILEFVLVYF-DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXX 1809
V+ SI + ++ D + +S LR R R+ K+ +
Sbjct: 1563 VLGSITDILVTEIADTDNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV 1622
Query: 1810 XXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMY 1989
GMQVFG + NF TF+QAL+ +F+ TGE W+ +M
Sbjct: 1623 CLLIAMLFFIYAIIGMQVFGNIALNDETSINRHNNFRTFLQALMLLFRSATGEAWHEIML 1682
Query: 1990 -----HGIESFGGV--GTLGVIVCIYYIV--LFICGNYILLNVFLAIAVDN 2115
+ G+ G +Y V +F+C ++++LN+F+A+ +DN
Sbjct: 1683 SCLSNRACDPLSGLTKNECGSDFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1732
Score = 122 bits (306), Expect = 1e-25
Identities = 81/293 (27%), Positives = 141/293 (47%), Gaps = 8/293 (2%)
Frame = +1
Query: 3268 FALKAKPHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFL 3447
F K K R +I R V +++F +++ ++ +NT+ +A HY L
Sbjct: 480 FRRKEKMFRFFIRR---------MVKAQSFYWIVLCVVALNTLCVAMVHYDQPEKLTTAL 530
Query: 3448 DVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLI 3627
+F G+F E LK+ L P+NY +N FD V+VGS ++ + + PG +
Sbjct: 531 YFAEFVFLGLFLTEMSLKMYGLGPRNYFHSSFNYFDFGVIVGSIFEVIWAAVKPGTS--F 588
Query: 3628 SINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF- 3804
I+ R R++R+ K+ +R L+ + + S +++ + L+ L ++A++GMQ F
Sbjct: 589 GISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFG 648
Query: 3805 GKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYH- 3981
G+ D T NF +FPAAIL +F+ TGE W +M YH
Sbjct: 649 GQFNFRDETP---TTNFDTFPAAILTVFQILTGEDWNAVM-----------------YHG 688
Query: 3982 ---KGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF---DYLTRD 4122
+GG++ F+ YFI + ++ ++N+F+A+ +DN LT+D
Sbjct: 689 IESQGGVHSGM----FSSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 737
Score = 95.9 bits (237), Expect = 1e-17
Identities = 77/316 (24%), Positives = 139/316 (43%), Gaps = 20/316 (6%)
Frame = +1
Query: 226 PIRKLCISIVEWK-----PFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVF 390
P K WK PFE+ I+ MI N I L + + Y A ++ +L+ + VF
Sbjct: 1474 PQNKQSFQYKMWKFVVSPPFEYFIMVMIALNTIVLMM-KFYDAPEA--YEEMLKCLNIVF 1530
Query: 391 IVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKA 564
+F++ECVLKI+A G + Y R+AWN+ DF+ V+ + ++++++ ++
Sbjct: 1531 TSMFSMECVLKIIAFGVL----NYFRDAWNVFDFVTVLGSITDILVTEIADTDNFINLSF 1586
Query: 565 LRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLH 744
LR FR R ++L+ +++++L +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1587 LRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF----- 1641
Query: 745 STCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITN 924
G +A D T N N
Sbjct: 1642 --------GNIALNDETSI------------------------------------NRHNN 1657
Query: 925 FDNFGLAMLTVFQCVSLEGWTDVMY-------------WVNDAVGREWPWIYFVTLVILG 1065
F F A++ +F+ + E W ++M + G ++ + YFV+ + L
Sbjct: 1658 FRTFLQALMLLFRSATGEAWHEIMLSCLSNRACDPLSGLTKNECGSDFAYFYFVSFIFLC 1717
Query: 1066 SFFVLNLVLGVLSGEF 1113
SF +LNL + V+ F
Sbjct: 1718 SFLMLNLFVAVIMDNF 1733
Score = 88.2 bits (217), Expect = 2e-15
Identities = 73/263 (27%), Positives = 119/263 (44%), Gaps = 14/263 (5%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLFI S N R + + F +L I+ + +LA E L M L+
Sbjct: 66 SLFIFSEDNVIRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 125
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV-----AVSLTSFVLRTDAM 2667
+ +F +F E +K+I G VFHKGS+ RN +N++D +VV A + T F LRT
Sbjct: 126 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDFDLRT--- 182
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
++ L+ V++ ++ A+ + I L+ F MFAIIG++ +
Sbjct: 183 -----LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAIVMFAIIGLEFY 237
Query: 2848 KGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSK----KRVWSNNDF---NFDNVGDA 3006
G F +K E G++ E+ P + + W ++ NFDN+ A
Sbjct: 238 MGKFHKTCFSNKTGEEV--GDFPCGEE-PPARQCESGTTCREYWQGPNYGITNFDNILFA 294
Query: 3007 MISLFVVSTFEGWPQLLYVAIDS 3075
++++F T EGW +LY D+
Sbjct: 295 VLTVFQCITMEGWTDILYNTNDA 317
Score = 85.9 bits (211), Expect = 1e-14
Identities = 75/291 (25%), Positives = 123/291 (41%), Gaps = 41/291 (14%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY+I I+ N + LA + H P + LD F G+F FEA +KI+AL
Sbjct: 89 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 148
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WNV D +VV+ G L GT+ + R RV+R +KL+S
Sbjct: 149 HKGSYLRNGWNVMDFVVVL-------TGILATAGTD-FDLRTLRAVRVLRPLKLVSGIPS 200
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQF----FGKVALDDSTSIHRNN---- 3849
++ +L + MK+ L + LL+ ++A+IG++F F K + T +
Sbjct: 201 LQVVLKSIMKAMVPLLQIGLLLFFAIVMFAIIGLEFYMGKFHKTCFSNKTGEEVGDFPCG 260
Query: 3850 --------------------------NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDV 3951
NF + A+L +F+ T E W DI+ + +D
Sbjct: 261 EEPPARQCESGTTCREYWQGPNYGITNFDNILFAVLTVFQCITMEGWTDILYNTND---- 316
Query: 3952 RCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
GN + + YFI ++ SF ++NL + V+ F
Sbjct: 317 -----------------AAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 350
Score = 53.5 bits (127), Expect = 6e-05
Identities = 55/274 (20%), Positives = 108/274 (39%), Gaps = 3/274 (1%)
Frame = +1
Query: 2293 AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN 2472
A +++K SS + FR F +V F VL C++ + + A
Sbjct: 465 ARASLKSGKNESSSYFRRKEKMFRFFIRRMVKAQSFYWIVL-CVVALNTLCVAMVHYDQP 523
Query: 2473 STRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL 2652
L + ++ F +F E++LK+ G ++ ++FN D V+ S+ +
Sbjct: 524 EKLTTALYFAEFVFLGLFLTEMSLKMYGLG----PRNYFHSSFNYFDFGVIVGSIFEVIW 579
Query: 2653 RTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
K L+++V ++ ++K+I +++ + F+ +F
Sbjct: 580 AAVKPGTSFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVF 639
Query: 2824 AIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGD 3003
A++G+QLF G F ++ D PT NFD
Sbjct: 640 ALLGMQLFGGQF-------------------NFRDETPTT-------------NFDTFPA 667
Query: 3004 AMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHN 3105
A++++F + T E W ++Y I+S +G +H+
Sbjct: 668 AILTVFQILTGEDWNAVMYHGIES----QGGVHS 697
>gi|45383554|ref|NP_989624.1| calcium channel, voltage-dependent, L
type, alpha 1B subunit [Gallus gallus]
gi|5802887|gb|AAD51815.1| N-type calcium channel alpha-1B cdB1
variant [Gallus gallus]
Length = 2357
Score = 679 bits (1753), Expect = 0.0
Identities = 357/766 (46%), Positives = 493/766 (63%), Gaps = 9/766 (1%)
Frame = +1
Query: 2308 KPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNM 2487
KPI SS+FILS TN R + +VN YF +L I +SS LAAEDP+QA S RN
Sbjct: 1142 KPILPYSSMFILSPTNPIRRLFHYIVNLRYFEMVILIVIALSSIALAAEDPVQAESPRND 1201
Query: 2488 ILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL---RT 2658
L Y DY FT VFT E+ +K+I GL+ H GS+ R+ +N+LD +VV+ +L +F +
Sbjct: 1202 ALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGSYFRDLWNILDFIVVSGALVAFAFSGTKG 1261
Query: 2659 DAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGV 2838
++ I R LK V CV+ ++K + NI++V + F+FA+I V
Sbjct: 1262 KDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAV 1321
Query: 2839 QLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISL 3018
QLFKG FF C D SK E +CRG+Y+ YE + ++ R W +F++DNV A+++L
Sbjct: 1322 QLFKGRFFYCTDESKELEKDCRGQYLDYEKNEVE---AQPREWKKYEFHYDNVLWALLTL 1378
Query: 3019 FVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIVT 3198
F VST EGWP +L ++D+ E++GP R +++ +I+T
Sbjct: 1379 FTVSTGEGWPTVLKHSVDATYEEQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIIT 1438
Query: 3199 FQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRAFEYVIF 3372
FQ +G++ C L+KN+R CI+FA+ AKP RY+P+N+ QY++W FV S FEY I
Sbjct: 1439 FQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNKQSFQYKMWKFVVSPPFEYFIM 1498
Query: 3373 LIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVF 3552
++I +NT+ L K Y + +E+ L N++FT +F+ E VLKI+A NY D WNVF
Sbjct: 1499 VMIALNTIVLMMKFYDAPEAYEEMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVF 1558
Query: 3553 DLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQ 3732
D + V+GS DI ++ N I+++F RLFR RL+KLL +G IR LLWTF++SF+
Sbjct: 1559 DFVTVLGSITDILVTEI-ADTDNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFK 1617
Query: 3733 ALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAW 3912
ALPYV LLI +LFFIYA+IGMQ FG +AL+D TSI+R+NNF +F A+++LFRSATGEAW
Sbjct: 1618 ALPYVCLLIAMLFFIYAIIGMQVFGNIALNDETSINRHNNFRTFLQALMLLFRSATGEAW 1677
Query: 3913 QDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVI 4092
+IMLSC CDP+S GL ++ CG++FAY YF+SF LCSFL++NLFVAVI
Sbjct: 1678 HEIMLSCLSNR--ACDPLS------GLTKNECGSDFAYFYFVSFIFLCSFLMLNLFVAVI 1729
Query: 4093 MDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCP 4272
MDNF+YLTRD SILGPHHL+EFVR+W+EYDP A RI + D+ LLR I+PPLG GK CP
Sbjct: 1730 MDNFEYLTRDSSILGPHHLDEFVRVWAEYDPAACCRIHYKDMYNLLRVIAPPLGLGKKCP 1789
Query: 4273 HRLACKRLVSMNMPLN-SDGTVCFNATLFALVRTNLKI-YTEGNI--DEANEQLRSAIKR 4440
HR+A KRLV MNMP++ D TV F +TL AL+RT L+I G + + + +LR I
Sbjct: 1790 HRVAYKRLVRMNMPISPEDLTVHFTSTLMALIRTALEIKLASGGVKQHQCDAELRKEISL 1849
Query: 4441 IWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKE 4578
+W + LD +VPP K D++TVGK YA +I D++++ K +E
Sbjct: 1850 VWPNLSQKTLDLLVPP-HKPDEMTVGKVYAALMIFDFYKQNKSSRE 1894
Score = 503 bits (1294), Expect = e-140
Identities = 290/693 (41%), Positives = 375/693 (53%), Gaps = 53/693 (7%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N IRK I EW PFE++IL I ANCI LA+ Q P D + L+ E FI +
Sbjct: 73 DNVIRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGI 132
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KI+A+GF+FH +YLRN WN++DF++V+ G+++T + FD++ LRA R
Sbjct: 133 FCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTD-----FDLRTLRAVR 187
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQVVL +I++AM+PLL I LL+ F I+++AIIGLE + GK H TC
Sbjct: 188 VLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAIVMFAIIGLEFYMGKFHKTCFS 247
Query: 760 PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTT----WPGPNNGITNF 927
TG+ + PCG + +C S TT W GPN GITNF
Sbjct: 248 NKTGE--EVGDFPCGEEPPAR-----------------QCESGTTCREYWQGPNYGITNF 288
Query: 928 DNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSG 1107
DN A+LTVFQC+++EGWTD++Y NDA G W W+YF+ L+I+GSFF+LNLVLGVLSG
Sbjct: 289 DNILFAVLTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSG 348
Query: 1108 EFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQ------------AEDIEPVNEDE 1251
EF+KERE+ R F K R +QQ+E +L GYL+WI + AE+ P++
Sbjct: 349 EFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDKNAEEKSPLDGRA 408
Query: 1252 QEDEPVAQTXXXXXXXXXXXX-------------------------------------XX 1320
+ P+ Q
Sbjct: 409 ASEGPIQQGTAPAETSSGSSYNMLKRAAIKKSKNDLIHAEEGEDHFTDICSVGSPFARAS 468
Query: 1321 XXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEW 1500
++ ++ +R EK+ +VK+Q+FYW HY Q E
Sbjct: 469 LKSGKNESSSYFRRKEKM---FRFFIRRMVKAQSFYWIVLCVVALNTLCVAMVHYDQPEK 525
Query: 1501 LDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLM 1680
L A F+ LF EM LKMY LG Y S FN FD V++ SI E +
Sbjct: 526 LTTALYFAEFVFLGLFLTEMSLKMYGLGPRNYFHSSFNYFDFGVIVGSIFEVIWAAVKPG 585
Query: 1681 KPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQ 1860
G+SVLR+ RLLRIFKVTKYW GMQ
Sbjct: 586 TSFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQ 645
Query: 1861 VFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVC 2040
+FGG+FNF + P NFDTF A+LTVFQILTGEDWN VMYHGIES GGV + G+
Sbjct: 646 LFGGQFNFRDE--TPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVHS-GMFSS 702
Query: 2041 IYYIVLFICGNYILLNVFLAIAVDNLADADSLT 2139
IY+IVL + GNY LLNVFLAIAVDNLA+A LT
Sbjct: 703 IYFIVLTLFGNYTLLNVFLAIAVDNLANAQELT 735
Score = 177 bits (448), Expect = 3e-42
Identities = 158/651 (24%), Positives = 276/651 (42%), Gaps = 20/651 (3%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR+L IV + FE +IL +I + IALA P A+ +N L+ ++Y+F VF
Sbjct: 1157 NPIRRLFHYIVNLRYFEMVILIVIALSSIALAAEDPVQAESP--RNDALKYLDYIFTGVF 1214
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD-VKALRAFR 579
T E V+K++ +G + HP +Y R+ WNILDFI+V LV+ S + + +K+LR R
Sbjct: 1215 TFEMVIKMIDLGLLLHPGSYFRDLWNILDFIVVSGALVAFAFSGTKGKDINTIKSLRVLR 1274
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF G+ C D
Sbjct: 1275 VLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGRFFY-CTD 1333
Query: 760 PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFG 939
+ + +KD D E + + QP + W+ ++DN
Sbjct: 1334 ES--KELEKDCRGQYLDYEKNEVEAQPRE--------WKKYE-----------FHYDNVL 1372
Query: 940 LAMLTVFQCVSLEGWTDVMYWVNDAVGREWP---------WIYFVTLVILGSFFVLNLVL 1092
A+LT+F + EGW V+ DA E I++V ++ FF +N+ +
Sbjct: 1373 WALLTLFTVSTGEGWPTVLKHSVDATYEEQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFV 1432
Query: 1093 GVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVA 1272
++ F ++ + K + LE++ + +D+ A+ +
Sbjct: 1433 ALIIITFQEQGD---------KVMSECSLEKNERACIDFAISAKPL-------------- 1469
Query: 1273 QTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXX 1452
P + ++ K V S F +
Sbjct: 1470 ----------------TRYMPQNKQSFQYKMWKF-----------VVSPPFEYFIMVMIA 1502
Query: 1453 XXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFV 1632
+ Y E + N+ F +FSME +LK+ + G Y +N FD
Sbjct: 1503 LNTIVLMMKFYDAPEAYEEMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVT 1562
Query: 1633 VISSILEFVLVYF-DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXX 1809
V+ SI + ++ D + +S LR R R+ K+ +
Sbjct: 1563 VLGSITDILVTEIADTDNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV 1622
Query: 1810 XXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMY 1989
GMQVFG + NF TF+QAL+ +F+ TGE W+ +M
Sbjct: 1623 CLLIAMLFFIYAIIGMQVFGNIALNDETSINRHNNFRTFLQALMLLFRSATGEAWHEIML 1682
Query: 1990 -----HGIESFGGV--GTLGVIVCIYYIV--LFICGNYILLNVFLAIAVDN 2115
+ G+ G +Y V +F+C ++++LN+F+A+ +DN
Sbjct: 1683 SCLSNRACDPLSGLTKNECGSDFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1732
Score = 122 bits (306), Expect = 1e-25
Identities = 81/293 (27%), Positives = 141/293 (47%), Gaps = 8/293 (2%)
Frame = +1
Query: 3268 FALKAKPHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFL 3447
F K K R +I R V +++F +++ ++ +NT+ +A HY L
Sbjct: 480 FRRKEKMFRFFIRR---------MVKAQSFYWIVLCVVALNTLCVAMVHYDQPEKLTTAL 530
Query: 3448 DVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLI 3627
+F G+F E LK+ L P+NY +N FD V+VGS ++ + + PG +
Sbjct: 531 YFAEFVFLGLFLTEMSLKMYGLGPRNYFHSSFNYFDFGVIVGSIFEVIWAAVKPGTS--F 588
Query: 3628 SINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF- 3804
I+ R R++R+ K+ +R L+ + + S +++ + L+ L ++A++GMQ F
Sbjct: 589 GISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFG 648
Query: 3805 GKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYH- 3981
G+ D T NF +FPAAIL +F+ TGE W +M YH
Sbjct: 649 GQFNFRDETP---TTNFDTFPAAILTVFQILTGEDWNAVM-----------------YHG 688
Query: 3982 ---KGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF---DYLTRD 4122
+GG++ F+ YFI + ++ ++N+F+A+ +DN LT+D
Sbjct: 689 IESQGGVHSGM----FSSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 737
Score = 95.9 bits (237), Expect = 1e-17
Identities = 77/316 (24%), Positives = 139/316 (43%), Gaps = 20/316 (6%)
Frame = +1
Query: 226 PIRKLCISIVEWK-----PFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVF 390
P K WK PFE+ I+ MI N I L + + Y A ++ +L+ + VF
Sbjct: 1474 PQNKQSFQYKMWKFVVSPPFEYFIMVMIALNTIVLMM-KFYDAPEA--YEEMLKCLNIVF 1530
Query: 391 IVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKA 564
+F++ECVLKI+A G + Y R+AWN+ DF+ V+ + ++++++ ++
Sbjct: 1531 TSMFSMECVLKIIAFGVL----NYFRDAWNVFDFVTVLGSITDILVTEIADTDNFINLSF 1586
Query: 565 LRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLH 744
LR FR R ++L+ +++++L +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1587 LRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF----- 1641
Query: 745 STCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITN 924
G +A D T N N
Sbjct: 1642 --------GNIALNDETSI------------------------------------NRHNN 1657
Query: 925 FDNFGLAMLTVFQCVSLEGWTDVMY-------------WVNDAVGREWPWIYFVTLVILG 1065
F F A++ +F+ + E W ++M + G ++ + YFV+ + L
Sbjct: 1658 FRTFLQALMLLFRSATGEAWHEIMLSCLSNRACDPLSGLTKNECGSDFAYFYFVSFIFLC 1717
Query: 1066 SFFVLNLVLGVLSGEF 1113
SF +LNL + V+ F
Sbjct: 1718 SFLMLNLFVAVIMDNF 1733
Score = 88.2 bits (217), Expect = 2e-15
Identities = 73/263 (27%), Positives = 119/263 (44%), Gaps = 14/263 (5%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLFI S N R + + F +L I+ + +LA E L M L+
Sbjct: 66 SLFIFSEDNVIRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 125
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV-----AVSLTSFVLRTDAM 2667
+ +F +F E +K+I G VFHKGS+ RN +N++D +VV A + T F LRT
Sbjct: 126 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDFDLRT--- 182
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
++ L+ V++ ++ A+ + I L+ F MFAIIG++ +
Sbjct: 183 -----LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAIVMFAIIGLEFY 237
Query: 2848 KGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSK----KRVWSNNDF---NFDNVGDA 3006
G F +K E G++ E+ P + + W ++ NFDN+ A
Sbjct: 238 MGKFHKTCFSNKTGEEV--GDFPCGEE-PPARQCESGTTCREYWQGPNYGITNFDNILFA 294
Query: 3007 MISLFVVSTFEGWPQLLYVAIDS 3075
++++F T EGW +LY D+
Sbjct: 295 VLTVFQCITMEGWTDILYNTNDA 317
Score = 85.9 bits (211), Expect = 1e-14
Identities = 75/291 (25%), Positives = 123/291 (41%), Gaps = 41/291 (14%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY+I I+ N + LA + H P + LD F G+F FEA +KI+AL
Sbjct: 89 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 148
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WNV D +VV+ G L GT+ + R RV+R +KL+S
Sbjct: 149 HKGSYLRNGWNVMDFVVVL-------TGILATAGTD-FDLRTLRAVRVLRPLKLVSGIPS 200
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQF----FGKVALDDSTSIHRNN---- 3849
++ +L + MK+ L + LL+ ++A+IG++F F K + T +
Sbjct: 201 LQVVLKSIMKAMVPLLQIGLLLFFAIVMFAIIGLEFYMGKFHKTCFSNKTGEEVGDFPCG 260
Query: 3850 --------------------------NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDV 3951
NF + A+L +F+ T E W DI+ + +D
Sbjct: 261 EEPPARQCESGTTCREYWQGPNYGITNFDNILFAVLTVFQCITMEGWTDILYNTND---- 316
Query: 3952 RCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
GN + + YFI ++ SF ++NL + V+ F
Sbjct: 317 -----------------AAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 350
Score = 53.5 bits (127), Expect = 6e-05
Identities = 55/274 (20%), Positives = 108/274 (39%), Gaps = 3/274 (1%)
Frame = +1
Query: 2293 AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN 2472
A +++K SS + FR F +V F VL C++ + + A
Sbjct: 465 ARASLKSGKNESSSYFRRKEKMFRFFIRRMVKAQSFYWIVL-CVVALNTLCVAMVHYDQP 523
Query: 2473 STRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL 2652
L + ++ F +F E++LK+ G ++ ++FN D V+ S+ +
Sbjct: 524 EKLTTALYFAEFVFLGLFLTEMSLKMYGLG----PRNYFHSSFNYFDFGVIVGSIFEVIW 579
Query: 2653 RTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
K L+++V ++ ++K+I +++ + F+ +F
Sbjct: 580 AAVKPGTSFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVF 639
Query: 2824 AIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGD 3003
A++G+QLF G F ++ D PT NFD
Sbjct: 640 ALLGMQLFGGQF-------------------NFRDETPTT-------------NFDTFPA 667
Query: 3004 AMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHN 3105
A++++F + T E W ++Y I+S +G +H+
Sbjct: 668 AILTVFQILTGEDWNAVMYHGIES----QGGVHS 697
>gi|5802895|gb|AAD51819.1| N-type calcium channel alpha-1B cdB5
variant [Gallus gallus]
Length = 2346
Score = 679 bits (1753), Expect = 0.0
Identities = 357/766 (46%), Positives = 493/766 (63%), Gaps = 9/766 (1%)
Frame = +1
Query: 2308 KPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNM 2487
KPI SS+FILS TN R + +VN YF +L I +SS LAAEDP+QA S RN
Sbjct: 1131 KPILPYSSMFILSPTNPIRRLFHYIVNLRYFEMVILIVIALSSIALAAEDPVQAESPRND 1190
Query: 2488 ILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL---RT 2658
L Y DY FT VFT E+ +K+I GL+ H GS+ R+ +N+LD +VV+ +L +F +
Sbjct: 1191 ALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGSYFRDLWNILDFIVVSGALVAFAFSGTKG 1250
Query: 2659 DAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGV 2838
++ I R LK V CV+ ++K + NI++V + F+FA+I V
Sbjct: 1251 KDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAV 1310
Query: 2839 QLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISL 3018
QLFKG FF C D SK E +CRG+Y+ YE + ++ R W +F++DNV A+++L
Sbjct: 1311 QLFKGRFFYCTDESKELEKDCRGQYLDYEKNEVE---AQPREWKKYEFHYDNVLWALLTL 1367
Query: 3019 FVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIVT 3198
F VST EGWP +L ++D+ E++GP R +++ +I+T
Sbjct: 1368 FTVSTGEGWPTVLKHSVDATYEEQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIIT 1427
Query: 3199 FQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRAFEYVIF 3372
FQ +G++ C L+KN+R CI+FA+ AKP RY+P+N+ QY++W FV S FEY I
Sbjct: 1428 FQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNKQSFQYKMWKFVVSPPFEYFIM 1487
Query: 3373 LIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVF 3552
++I +NT+ L K Y + +E+ L N++FT +F+ E VLKI+A NY D WNVF
Sbjct: 1488 VMIALNTIVLMMKFYDAPEAYEEMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVF 1547
Query: 3553 DLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQ 3732
D + V+GS DI ++ N I+++F RLFR RL+KLL +G IR LLWTF++SF+
Sbjct: 1548 DFVTVLGSITDILVTEI-ADTDNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFK 1606
Query: 3733 ALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAW 3912
ALPYV LLI +LFFIYA+IGMQ FG +AL+D TSI+R+NNF +F A+++LFRSATGEAW
Sbjct: 1607 ALPYVCLLIAMLFFIYAIIGMQVFGNIALNDETSINRHNNFRTFLQALMLLFRSATGEAW 1666
Query: 3913 QDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVI 4092
+IMLSC CDP+S GL ++ CG++FAY YF+SF LCSFL++NLFVAVI
Sbjct: 1667 HEIMLSCLSNR--ACDPLS------GLTKNECGSDFAYFYFVSFIFLCSFLMLNLFVAVI 1718
Query: 4093 MDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCP 4272
MDNF+YLTRD SILGPHHL+EFVR+W+EYDP A RI + D+ LLR I+PPLG GK CP
Sbjct: 1719 MDNFEYLTRDSSILGPHHLDEFVRVWAEYDPAACCRIHYKDMYNLLRVIAPPLGLGKKCP 1778
Query: 4273 HRLACKRLVSMNMPLN-SDGTVCFNATLFALVRTNLKI-YTEGNI--DEANEQLRSAIKR 4440
HR+A KRLV MNMP++ D TV F +TL AL+RT L+I G + + + +LR I
Sbjct: 1779 HRVAYKRLVRMNMPISPEDLTVHFTSTLMALIRTALEIKLASGGVKQHQCDAELRKEISL 1838
Query: 4441 IWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKE 4578
+W + LD +VPP K D++TVGK YA +I D++++ K +E
Sbjct: 1839 VWPNLSQKTLDLLVPP-HKPDEMTVGKVYAALMIFDFYKQNKSSRE 1883
Score = 513 bits (1321), Expect = e-143
Identities = 292/682 (42%), Positives = 377/682 (54%), Gaps = 42/682 (6%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N IRK I EW PFE++IL I ANCI LA+ Q P D + L+ E FI +
Sbjct: 73 DNVIRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGI 132
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KI+A+GF+FH +YLRN WN++DF++V+ G+++T + FD++ LRA R
Sbjct: 133 FCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTD-----FDLRTLRAVR 187
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQVVL +I++AM+PLL I LL+ F I+++AIIGLE + GK H TC
Sbjct: 188 VLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAIVMFAIIGLEFYMGKFHKTCFS 247
Query: 760 PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTT----WPGPNNGITNF 927
TG+ + PCG + +C S TT W GPN GITNF
Sbjct: 248 NKTGE--EVGDFPCGEEPPAR-----------------QCESGTTCREYWQGPNYGITNF 288
Query: 928 DNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSG 1107
DN A+LTVFQC+++EGWTD++Y NDA G W W+YF+ L+I+GSFF+LNLVLGVLSG
Sbjct: 289 DNILFAVLTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSG 348
Query: 1108 EFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDE-------- 1263
EF+KERE+ R F K R +QQ+E +L GYL+WI +AE++ ED+ +E
Sbjct: 349 EFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDKNAEEKSPLDGRA 408
Query: 1264 ----PVAQTXXXXXXXXXX--------------------------XXXXXXXXPSKWAAR 1353
P+ Q ++ ++
Sbjct: 409 ASEGPIQQGTAPAETSSGSSYNMLKRAAIKKSKNDLIHAEEGSPFARASLKSGKNESSSY 468
Query: 1354 MKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLF 1533
+R EK+ +VK+Q+FYW HY Q E L A
Sbjct: 469 FRRKEKM---FRFFIRRMVKAQSFYWIVLCVVALNTLCVAMVHYDQPEKLTTALYFAEFV 525
Query: 1534 FVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSA 1713
F+ LF EM LKMY LG Y S FN FD V++ SI E + G+SVLR+
Sbjct: 526 FLGLFLTEMSLKMYGLGPRNYFHSSFNYFDFGVIVGSIFEVIWAAVKPGTSFGISVLRAL 585
Query: 1714 RLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQ 1893
RLLRIFKVTKYW GMQ+FGG+FNF +
Sbjct: 586 RLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFRDE 645
Query: 1894 QPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGN 2073
P NFDTF A+LTVFQILTGEDWN VMYHGIES GGV + G+ IY+IVL + GN
Sbjct: 646 --TPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVHS-GMFSSIYFIVLTLFGN 702
Query: 2074 YILLNVFLAIAVDNLADADSLT 2139
Y LLNVFLAIAVDNLA+A LT
Sbjct: 703 YTLLNVFLAIAVDNLANAQELT 724
Score = 177 bits (448), Expect = 3e-42
Identities = 158/651 (24%), Positives = 276/651 (42%), Gaps = 20/651 (3%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR+L IV + FE +IL +I + IALA P A+ +N L+ ++Y+F VF
Sbjct: 1146 NPIRRLFHYIVNLRYFEMVILIVIALSSIALAAEDPVQAESP--RNDALKYLDYIFTGVF 1203
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD-VKALRAFR 579
T E V+K++ +G + HP +Y R+ WNILDFI+V LV+ S + + +K+LR R
Sbjct: 1204 TFEMVIKMIDLGLLLHPGSYFRDLWNILDFIVVSGALVAFAFSGTKGKDINTIKSLRVLR 1263
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF G+ C D
Sbjct: 1264 VLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGRFFY-CTD 1322
Query: 760 PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFG 939
+ + +KD D E + + QP + W+ ++DN
Sbjct: 1323 ES--KELEKDCRGQYLDYEKNEVEAQPRE--------WKKYE-----------FHYDNVL 1361
Query: 940 LAMLTVFQCVSLEGWTDVMYWVNDAVGREWP---------WIYFVTLVILGSFFVLNLVL 1092
A+LT+F + EGW V+ DA E I++V ++ FF +N+ +
Sbjct: 1362 WALLTLFTVSTGEGWPTVLKHSVDATYEEQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFV 1421
Query: 1093 GVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVA 1272
++ F ++ + K + LE++ + +D+ A+ +
Sbjct: 1422 ALIIITFQEQGD---------KVMSECSLEKNERACIDFAISAKPL-------------- 1458
Query: 1273 QTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXX 1452
P + ++ K V S F +
Sbjct: 1459 ----------------TRYMPQNKQSFQYKMWKF-----------VVSPPFEYFIMVMIA 1491
Query: 1453 XXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFV 1632
+ Y E + N+ F +FSME +LK+ + G Y +N FD
Sbjct: 1492 LNTIVLMMKFYDAPEAYEEMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVT 1551
Query: 1633 VISSILEFVLVYF-DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXX 1809
V+ SI + ++ D + +S LR R R+ K+ +
Sbjct: 1552 VLGSITDILVTEIADTDNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV 1611
Query: 1810 XXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMY 1989
GMQVFG + NF TF+QAL+ +F+ TGE W+ +M
Sbjct: 1612 CLLIAMLFFIYAIIGMQVFGNIALNDETSINRHNNFRTFLQALMLLFRSATGEAWHEIML 1671
Query: 1990 -----HGIESFGGV--GTLGVIVCIYYIV--LFICGNYILLNVFLAIAVDN 2115
+ G+ G +Y V +F+C ++++LN+F+A+ +DN
Sbjct: 1672 SCLSNRACDPLSGLTKNECGSDFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1721
Score = 122 bits (306), Expect = 1e-25
Identities = 81/293 (27%), Positives = 141/293 (47%), Gaps = 8/293 (2%)
Frame = +1
Query: 3268 FALKAKPHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFL 3447
F K K R +I R V +++F +++ ++ +NT+ +A HY L
Sbjct: 469 FRRKEKMFRFFIRR---------MVKAQSFYWIVLCVVALNTLCVAMVHYDQPEKLTTAL 519
Query: 3448 DVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLI 3627
+F G+F E LK+ L P+NY +N FD V+VGS ++ + + PG +
Sbjct: 520 YFAEFVFLGLFLTEMSLKMYGLGPRNYFHSSFNYFDFGVIVGSIFEVIWAAVKPGTS--F 577
Query: 3628 SINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF- 3804
I+ R R++R+ K+ +R L+ + + S +++ + L+ L ++A++GMQ F
Sbjct: 578 GISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFG 637
Query: 3805 GKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYH- 3981
G+ D T NF +FPAAIL +F+ TGE W +M YH
Sbjct: 638 GQFNFRDETP---TTNFDTFPAAILTVFQILTGEDWNAVM-----------------YHG 677
Query: 3982 ---KGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF---DYLTRD 4122
+GG++ F+ YFI + ++ ++N+F+A+ +DN LT+D
Sbjct: 678 IESQGGVHSGM----FSSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 726
Score = 95.9 bits (237), Expect = 1e-17
Identities = 77/316 (24%), Positives = 139/316 (43%), Gaps = 20/316 (6%)
Frame = +1
Query: 226 PIRKLCISIVEWK-----PFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVF 390
P K WK PFE+ I+ MI N I L + + Y A ++ +L+ + VF
Sbjct: 1463 PQNKQSFQYKMWKFVVSPPFEYFIMVMIALNTIVLMM-KFYDAPEA--YEEMLKCLNIVF 1519
Query: 391 IVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKA 564
+F++ECVLKI+A G + Y R+AWN+ DF+ V+ + ++++++ ++
Sbjct: 1520 TSMFSMECVLKIIAFGVL----NYFRDAWNVFDFVTVLGSITDILVTEIADTDNFINLSF 1575
Query: 565 LRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLH 744
LR FR R ++L+ +++++L +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1576 LRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF----- 1630
Query: 745 STCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITN 924
G +A D T N N
Sbjct: 1631 --------GNIALNDETSI------------------------------------NRHNN 1646
Query: 925 FDNFGLAMLTVFQCVSLEGWTDVMY-------------WVNDAVGREWPWIYFVTLVILG 1065
F F A++ +F+ + E W ++M + G ++ + YFV+ + L
Sbjct: 1647 FRTFLQALMLLFRSATGEAWHEIMLSCLSNRACDPLSGLTKNECGSDFAYFYFVSFIFLC 1706
Query: 1066 SFFVLNLVLGVLSGEF 1113
SF +LNL + V+ F
Sbjct: 1707 SFLMLNLFVAVIMDNF 1722
Score = 88.2 bits (217), Expect = 2e-15
Identities = 73/263 (27%), Positives = 119/263 (44%), Gaps = 14/263 (5%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLFI S N R + + F +L I+ + +LA E L M L+
Sbjct: 66 SLFIFSEDNVIRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 125
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV-----AVSLTSFVLRTDAM 2667
+ +F +F E +K+I G VFHKGS+ RN +N++D +VV A + T F LRT
Sbjct: 126 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDFDLRT--- 182
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
++ L+ V++ ++ A+ + I L+ F MFAIIG++ +
Sbjct: 183 -----LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAIVMFAIIGLEFY 237
Query: 2848 KGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSK----KRVWSNNDF---NFDNVGDA 3006
G F +K E G++ E+ P + + W ++ NFDN+ A
Sbjct: 238 MGKFHKTCFSNKTGEEV--GDFPCGEE-PPARQCESGTTCREYWQGPNYGITNFDNILFA 294
Query: 3007 MISLFVVSTFEGWPQLLYVAIDS 3075
++++F T EGW +LY D+
Sbjct: 295 VLTVFQCITMEGWTDILYNTNDA 317
Score = 85.9 bits (211), Expect = 1e-14
Identities = 75/291 (25%), Positives = 123/291 (41%), Gaps = 41/291 (14%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY+I I+ N + LA + H P + LD F G+F FEA +KI+AL
Sbjct: 89 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 148
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WNV D +VV+ G L GT+ + R RV+R +KL+S
Sbjct: 149 HKGSYLRNGWNVMDFVVVL-------TGILATAGTD-FDLRTLRAVRVLRPLKLVSGIPS 200
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQF----FGKVALDDSTSIHRNN---- 3849
++ +L + MK+ L + LL+ ++A+IG++F F K + T +
Sbjct: 201 LQVVLKSIMKAMVPLLQIGLLLFFAIVMFAIIGLEFYMGKFHKTCFSNKTGEEVGDFPCG 260
Query: 3850 --------------------------NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDV 3951
NF + A+L +F+ T E W DI+ + +D
Sbjct: 261 EEPPARQCESGTTCREYWQGPNYGITNFDNILFAVLTVFQCITMEGWTDILYNTND---- 316
Query: 3952 RCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
GN + + YFI ++ SF ++NL + V+ F
Sbjct: 317 -----------------AAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 350
Score = 53.5 bits (127), Expect = 6e-05
Identities = 55/274 (20%), Positives = 108/274 (39%), Gaps = 3/274 (1%)
Frame = +1
Query: 2293 AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN 2472
A +++K SS + FR F +V F VL C++ + + A
Sbjct: 454 ARASLKSGKNESSSYFRRKEKMFRFFIRRMVKAQSFYWIVL-CVVALNTLCVAMVHYDQP 512
Query: 2473 STRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL 2652
L + ++ F +F E++LK+ G ++ ++FN D V+ S+ +
Sbjct: 513 EKLTTALYFAEFVFLGLFLTEMSLKMYGLG----PRNYFHSSFNYFDFGVIVGSIFEVIW 568
Query: 2653 RTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
K L+++V ++ ++K+I +++ + F+ +F
Sbjct: 569 AAVKPGTSFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
Query: 2824 AIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGD 3003
A++G+QLF G F ++ D PT NFD
Sbjct: 629 ALLGMQLFGGQF-------------------NFRDETPTT-------------NFDTFPA 656
Query: 3004 AMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHN 3105
A++++F + T E W ++Y I+S +G +H+
Sbjct: 657 AILTVFQILTGEDWNAVMYHGIES----QGGVHS 686
>gi|5802897|gb|AAD51820.1| N-type calcium channel alpha-1B cdB6
variant [Gallus gallus]
Length = 2171
Score = 679 bits (1753), Expect = 0.0
Identities = 357/766 (46%), Positives = 493/766 (63%), Gaps = 9/766 (1%)
Frame = +1
Query: 2308 KPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNM 2487
KPI SS+FILS TN R + +VN YF +L I +SS LAAEDP+QA S RN
Sbjct: 1131 KPILPYSSMFILSPTNPIRRLFHYIVNLRYFEMVILIVIALSSIALAAEDPVQAESPRND 1190
Query: 2488 ILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL---RT 2658
L Y DY FT VFT E+ +K+I GL+ H GS+ R+ +N+LD +VV+ +L +F +
Sbjct: 1191 ALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGSYFRDLWNILDFIVVSGALVAFAFSGTKG 1250
Query: 2659 DAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGV 2838
++ I R LK V CV+ ++K + NI++V + F+FA+I V
Sbjct: 1251 KDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAV 1310
Query: 2839 QLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISL 3018
QLFKG FF C D SK E +CRG+Y+ YE + ++ R W +F++DNV A+++L
Sbjct: 1311 QLFKGRFFYCTDESKELEKDCRGQYLDYEKNEVE---AQPREWKKYEFHYDNVLWALLTL 1367
Query: 3019 FVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIVT 3198
F VST EGWP +L ++D+ E++GP R +++ +I+T
Sbjct: 1368 FTVSTGEGWPTVLKHSVDATYEEQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIIT 1427
Query: 3199 FQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRAFEYVIF 3372
FQ +G++ C L+KN+R CI+FA+ AKP RY+P+N+ QY++W FV S FEY I
Sbjct: 1428 FQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNKQSFQYKMWKFVVSPPFEYFIM 1487
Query: 3373 LIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVF 3552
++I +NT+ L K Y + +E+ L N++FT +F+ E VLKI+A NY D WNVF
Sbjct: 1488 VMIALNTIVLMMKFYDAPEAYEEMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVF 1547
Query: 3553 DLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQ 3732
D + V+GS DI ++ N I+++F RLFR RL+KLL +G IR LLWTF++SF+
Sbjct: 1548 DFVTVLGSITDILVTEI-ADTDNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFK 1606
Query: 3733 ALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAW 3912
ALPYV LLI +LFFIYA+IGMQ FG +AL+D TSI+R+NNF +F A+++LFRSATGEAW
Sbjct: 1607 ALPYVCLLIAMLFFIYAIIGMQVFGNIALNDETSINRHNNFRTFLQALMLLFRSATGEAW 1666
Query: 3913 QDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVI 4092
+IMLSC CDP+S GL ++ CG++FAY YF+SF LCSFL++NLFVAVI
Sbjct: 1667 HEIMLSCLSNR--ACDPLS------GLTKNECGSDFAYFYFVSFIFLCSFLMLNLFVAVI 1718
Query: 4093 MDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCP 4272
MDNF+YLTRD SILGPHHL+EFVR+W+EYDP A RI + D+ LLR I+PPLG GK CP
Sbjct: 1719 MDNFEYLTRDSSILGPHHLDEFVRVWAEYDPAACCRIHYKDMYNLLRVIAPPLGLGKKCP 1778
Query: 4273 HRLACKRLVSMNMPLN-SDGTVCFNATLFALVRTNLKI-YTEGNI--DEANEQLRSAIKR 4440
HR+A KRLV MNMP++ D TV F +TL AL+RT L+I G + + + +LR I
Sbjct: 1779 HRVAYKRLVRMNMPISPEDLTVHFTSTLMALIRTALEIKLASGGVKQHQCDAELRKEISL 1838
Query: 4441 IWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKE 4578
+W + LD +VPP K D++TVGK YA +I D++++ K +E
Sbjct: 1839 VWPNLSQKTLDLLVPP-HKPDEMTVGKVYAALMIFDFYKQNKSSRE 1883
Score = 513 bits (1321), Expect = e-143
Identities = 292/682 (42%), Positives = 377/682 (54%), Gaps = 42/682 (6%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N IRK I EW PFE++IL I ANCI LA+ Q P D + L+ E FI +
Sbjct: 73 DNVIRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGI 132
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KI+A+GF+FH +YLRN WN++DF++V+ G+++T + FD++ LRA R
Sbjct: 133 FCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTD-----FDLRTLRAVR 187
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQVVL +I++AM+PLL I LL+ F I+++AIIGLE + GK H TC
Sbjct: 188 VLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAIVMFAIIGLEFYMGKFHKTCFS 247
Query: 760 PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTT----WPGPNNGITNF 927
TG+ + PCG + +C S TT W GPN GITNF
Sbjct: 248 NKTGE--EVGDFPCGEEPPAR-----------------QCESGTTCREYWQGPNYGITNF 288
Query: 928 DNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSG 1107
DN A+LTVFQC+++EGWTD++Y NDA G W W+YF+ L+I+GSFF+LNLVLGVLSG
Sbjct: 289 DNILFAVLTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSG 348
Query: 1108 EFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDE-------- 1263
EF+KERE+ R F K R +QQ+E +L GYL+WI +AE++ ED+ +E
Sbjct: 349 EFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDKNAEEKSPLDGRA 408
Query: 1264 ----PVAQTXXXXXXXXXX--------------------------XXXXXXXXPSKWAAR 1353
P+ Q ++ ++
Sbjct: 409 ASEGPIQQGTAPAETSSGSSYNMLKRAAIKKSKNDLIHAEEGSPFARASLKSGKNESSSY 468
Query: 1354 MKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLF 1533
+R EK+ +VK+Q+FYW HY Q E L A
Sbjct: 469 FRRKEKM---FRFFIRRMVKAQSFYWIVLCVVALNTLCVAMVHYDQPEKLTTALYFAEFV 525
Query: 1534 FVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSA 1713
F+ LF EM LKMY LG Y S FN FD V++ SI E + G+SVLR+
Sbjct: 526 FLGLFLTEMSLKMYGLGPRNYFHSSFNYFDFGVIVGSIFEVIWAAVKPGTSFGISVLRAL 585
Query: 1714 RLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQ 1893
RLLRIFKVTKYW GMQ+FGG+FNF +
Sbjct: 586 RLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFRDE 645
Query: 1894 QPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGN 2073
P NFDTF A+LTVFQILTGEDWN VMYHGIES GGV + G+ IY+IVL + GN
Sbjct: 646 --TPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVHS-GMFSSIYFIVLTLFGN 702
Query: 2074 YILLNVFLAIAVDNLADADSLT 2139
Y LLNVFLAIAVDNLA+A LT
Sbjct: 703 YTLLNVFLAIAVDNLANAQELT 724
Score = 177 bits (448), Expect = 3e-42
Identities = 158/651 (24%), Positives = 276/651 (42%), Gaps = 20/651 (3%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR+L IV + FE +IL +I + IALA P A+ +N L+ ++Y+F VF
Sbjct: 1146 NPIRRLFHYIVNLRYFEMVILIVIALSSIALAAEDPVQAESP--RNDALKYLDYIFTGVF 1203
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD-VKALRAFR 579
T E V+K++ +G + HP +Y R+ WNILDFI+V LV+ S + + +K+LR R
Sbjct: 1204 TFEMVIKMIDLGLLLHPGSYFRDLWNILDFIVVSGALVAFAFSGTKGKDINTIKSLRVLR 1263
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF G+ C D
Sbjct: 1264 VLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGRFFY-CTD 1322
Query: 760 PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFG 939
+ + +KD D E + + QP + W+ ++DN
Sbjct: 1323 ES--KELEKDCRGQYLDYEKNEVEAQPRE--------WKKYE-----------FHYDNVL 1361
Query: 940 LAMLTVFQCVSLEGWTDVMYWVNDAVGREWP---------WIYFVTLVILGSFFVLNLVL 1092
A+LT+F + EGW V+ DA E I++V ++ FF +N+ +
Sbjct: 1362 WALLTLFTVSTGEGWPTVLKHSVDATYEEQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFV 1421
Query: 1093 GVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVA 1272
++ F ++ + K + LE++ + +D+ A+ +
Sbjct: 1422 ALIIITFQEQGD---------KVMSECSLEKNERACIDFAISAKPL-------------- 1458
Query: 1273 QTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXX 1452
P + ++ K V S F +
Sbjct: 1459 ----------------TRYMPQNKQSFQYKMWKF-----------VVSPPFEYFIMVMIA 1491
Query: 1453 XXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFV 1632
+ Y E + N+ F +FSME +LK+ + G Y +N FD
Sbjct: 1492 LNTIVLMMKFYDAPEAYEEMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVT 1551
Query: 1633 VISSILEFVLVYF-DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXX 1809
V+ SI + ++ D + +S LR R R+ K+ +
Sbjct: 1552 VLGSITDILVTEIADTDNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV 1611
Query: 1810 XXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMY 1989
GMQVFG + NF TF+QAL+ +F+ TGE W+ +M
Sbjct: 1612 CLLIAMLFFIYAIIGMQVFGNIALNDETSINRHNNFRTFLQALMLLFRSATGEAWHEIML 1671
Query: 1990 -----HGIESFGGV--GTLGVIVCIYYIV--LFICGNYILLNVFLAIAVDN 2115
+ G+ G +Y V +F+C ++++LN+F+A+ +DN
Sbjct: 1672 SCLSNRACDPLSGLTKNECGSDFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1721
Score = 122 bits (306), Expect = 1e-25
Identities = 81/293 (27%), Positives = 141/293 (47%), Gaps = 8/293 (2%)
Frame = +1
Query: 3268 FALKAKPHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFL 3447
F K K R +I R V +++F +++ ++ +NT+ +A HY L
Sbjct: 469 FRRKEKMFRFFIRR---------MVKAQSFYWIVLCVVALNTLCVAMVHYDQPEKLTTAL 519
Query: 3448 DVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLI 3627
+F G+F E LK+ L P+NY +N FD V+VGS ++ + + PG +
Sbjct: 520 YFAEFVFLGLFLTEMSLKMYGLGPRNYFHSSFNYFDFGVIVGSIFEVIWAAVKPGTS--F 577
Query: 3628 SINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF- 3804
I+ R R++R+ K+ +R L+ + + S +++ + L+ L ++A++GMQ F
Sbjct: 578 GISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFG 637
Query: 3805 GKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYH- 3981
G+ D T NF +FPAAIL +F+ TGE W +M YH
Sbjct: 638 GQFNFRDETP---TTNFDTFPAAILTVFQILTGEDWNAVM-----------------YHG 677
Query: 3982 ---KGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF---DYLTRD 4122
+GG++ F+ YFI + ++ ++N+F+A+ +DN LT+D
Sbjct: 678 IESQGGVHSGM----FSSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 726
Score = 95.9 bits (237), Expect = 1e-17
Identities = 77/316 (24%), Positives = 139/316 (43%), Gaps = 20/316 (6%)
Frame = +1
Query: 226 PIRKLCISIVEWK-----PFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVF 390
P K WK PFE+ I+ MI N I L + + Y A ++ +L+ + VF
Sbjct: 1463 PQNKQSFQYKMWKFVVSPPFEYFIMVMIALNTIVLMM-KFYDAPEA--YEEMLKCLNIVF 1519
Query: 391 IVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKA 564
+F++ECVLKI+A G + Y R+AWN+ DF+ V+ + ++++++ ++
Sbjct: 1520 TSMFSMECVLKIIAFGVL----NYFRDAWNVFDFVTVLGSITDILVTEIADTDNFINLSF 1575
Query: 565 LRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLH 744
LR FR R ++L+ +++++L +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1576 LRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF----- 1630
Query: 745 STCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITN 924
G +A D T N N
Sbjct: 1631 --------GNIALNDETSI------------------------------------NRHNN 1646
Query: 925 FDNFGLAMLTVFQCVSLEGWTDVMY-------------WVNDAVGREWPWIYFVTLVILG 1065
F F A++ +F+ + E W ++M + G ++ + YFV+ + L
Sbjct: 1647 FRTFLQALMLLFRSATGEAWHEIMLSCLSNRACDPLSGLTKNECGSDFAYFYFVSFIFLC 1706
Query: 1066 SFFVLNLVLGVLSGEF 1113
SF +LNL + V+ F
Sbjct: 1707 SFLMLNLFVAVIMDNF 1722
Score = 88.2 bits (217), Expect = 2e-15
Identities = 73/263 (27%), Positives = 119/263 (44%), Gaps = 14/263 (5%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLFI S N R + + F +L I+ + +LA E L M L+
Sbjct: 66 SLFIFSEDNVIRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 125
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV-----AVSLTSFVLRTDAM 2667
+ +F +F E +K+I G VFHKGS+ RN +N++D +VV A + T F LRT
Sbjct: 126 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDFDLRT--- 182
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
++ L+ V++ ++ A+ + I L+ F MFAIIG++ +
Sbjct: 183 -----LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAIVMFAIIGLEFY 237
Query: 2848 KGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSK----KRVWSNNDF---NFDNVGDA 3006
G F +K E G++ E+ P + + W ++ NFDN+ A
Sbjct: 238 MGKFHKTCFSNKTGEEV--GDFPCGEE-PPARQCESGTTCREYWQGPNYGITNFDNILFA 294
Query: 3007 MISLFVVSTFEGWPQLLYVAIDS 3075
++++F T EGW +LY D+
Sbjct: 295 VLTVFQCITMEGWTDILYNTNDA 317
Score = 85.9 bits (211), Expect = 1e-14
Identities = 75/291 (25%), Positives = 123/291 (41%), Gaps = 41/291 (14%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY+I I+ N + LA + H P + LD F G+F FEA +KI+AL
Sbjct: 89 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 148
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WNV D +VV+ G L GT+ + R RV+R +KL+S
Sbjct: 149 HKGSYLRNGWNVMDFVVVL-------TGILATAGTD-FDLRTLRAVRVLRPLKLVSGIPS 200
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQF----FGKVALDDSTSIHRNN---- 3849
++ +L + MK+ L + LL+ ++A+IG++F F K + T +
Sbjct: 201 LQVVLKSIMKAMVPLLQIGLLLFFAIVMFAIIGLEFYMGKFHKTCFSNKTGEEVGDFPCG 260
Query: 3850 --------------------------NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDV 3951
NF + A+L +F+ T E W DI+ + +D
Sbjct: 261 EEPPARQCESGTTCREYWQGPNYGITNFDNILFAVLTVFQCITMEGWTDILYNTND---- 316
Query: 3952 RCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
GN + + YFI ++ SF ++NL + V+ F
Sbjct: 317 -----------------AAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 350
Score = 53.5 bits (127), Expect = 6e-05
Identities = 55/274 (20%), Positives = 108/274 (39%), Gaps = 3/274 (1%)
Frame = +1
Query: 2293 AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN 2472
A +++K SS + FR F +V F VL C++ + + A
Sbjct: 454 ARASLKSGKNESSSYFRRKEKMFRFFIRRMVKAQSFYWIVL-CVVALNTLCVAMVHYDQP 512
Query: 2473 STRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL 2652
L + ++ F +F E++LK+ G ++ ++FN D V+ S+ +
Sbjct: 513 EKLTTALYFAEFVFLGLFLTEMSLKMYGLG----PRNYFHSSFNYFDFGVIVGSIFEVIW 568
Query: 2653 RTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
K L+++V ++ ++K+I +++ + F+ +F
Sbjct: 569 AAVKPGTSFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
Query: 2824 AIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGD 3003
A++G+QLF G F ++ D PT NFD
Sbjct: 629 ALLGMQLFGGQF-------------------NFRDETPTT-------------NFDTFPA 656
Query: 3004 AMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHN 3105
A++++F + T E W ++Y I+S +G +H+
Sbjct: 657 AILTVFQILTGEDWNAVMYHGIES----QGGVHS 686
>gi|5802893|gb|AAD51818.1| N-type calcium channel alpha-1B cdB4
variant [Gallus gallus]
Length = 2146
Score = 679 bits (1753), Expect = 0.0
Identities = 357/766 (46%), Positives = 493/766 (63%), Gaps = 9/766 (1%)
Frame = +1
Query: 2308 KPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNM 2487
KPI SS+FILS TN R + +VN YF +L I +SS LAAEDP+QA S RN
Sbjct: 1106 KPILPYSSMFILSPTNPIRRLFHYIVNLRYFEMVILIVIALSSIALAAEDPVQAESPRND 1165
Query: 2488 ILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL---RT 2658
L Y DY FT VFT E+ +K+I GL+ H GS+ R+ +N+LD +VV+ +L +F +
Sbjct: 1166 ALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGSYFRDLWNILDFIVVSGALVAFAFSGTKG 1225
Query: 2659 DAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGV 2838
++ I R LK V CV+ ++K + NI++V + F+FA+I V
Sbjct: 1226 KDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAV 1285
Query: 2839 QLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISL 3018
QLFKG FF C D SK E +CRG+Y+ YE + ++ R W +F++DNV A+++L
Sbjct: 1286 QLFKGRFFYCTDESKELEKDCRGQYLDYEKNEVE---AQPREWKKYEFHYDNVLWALLTL 1342
Query: 3019 FVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIVT 3198
F VST EGWP +L ++D+ E++GP R +++ +I+T
Sbjct: 1343 FTVSTGEGWPTVLKHSVDATYEEQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIIT 1402
Query: 3199 FQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRAFEYVIF 3372
FQ +G++ C L+KN+R CI+FA+ AKP RY+P+N+ QY++W FV S FEY I
Sbjct: 1403 FQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNKQSFQYKMWKFVVSPPFEYFIM 1462
Query: 3373 LIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVF 3552
++I +NT+ L K Y + +E+ L N++FT +F+ E VLKI+A NY D WNVF
Sbjct: 1463 VMIALNTIVLMMKFYDAPEAYEEMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVF 1522
Query: 3553 DLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQ 3732
D + V+GS DI ++ N I+++F RLFR RL+KLL +G IR LLWTF++SF+
Sbjct: 1523 DFVTVLGSITDILVTEI-ADTDNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFK 1581
Query: 3733 ALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAW 3912
ALPYV LLI +LFFIYA+IGMQ FG +AL+D TSI+R+NNF +F A+++LFRSATGEAW
Sbjct: 1582 ALPYVCLLIAMLFFIYAIIGMQVFGNIALNDETSINRHNNFRTFLQALMLLFRSATGEAW 1641
Query: 3913 QDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVI 4092
+IMLSC CDP+S GL ++ CG++FAY YF+SF LCSFL++NLFVAVI
Sbjct: 1642 HEIMLSCLSNR--ACDPLS------GLTKNECGSDFAYFYFVSFIFLCSFLMLNLFVAVI 1693
Query: 4093 MDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCP 4272
MDNF+YLTRD SILGPHHL+EFVR+W+EYDP A RI + D+ LLR I+PPLG GK CP
Sbjct: 1694 MDNFEYLTRDSSILGPHHLDEFVRVWAEYDPAACCRIHYKDMYNLLRVIAPPLGLGKKCP 1753
Query: 4273 HRLACKRLVSMNMPLN-SDGTVCFNATLFALVRTNLKI-YTEGNI--DEANEQLRSAIKR 4440
HR+A KRLV MNMP++ D TV F +TL AL+RT L+I G + + + +LR I
Sbjct: 1754 HRVAYKRLVRMNMPISPEDLTVHFTSTLMALIRTALEIKLASGGVKQHQCDAELRKEISL 1813
Query: 4441 IWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKE 4578
+W + LD +VPP K D++TVGK YA +I D++++ K +E
Sbjct: 1814 VWPNLSQKTLDLLVPP-HKPDEMTVGKVYAALMIFDFYKQNKSSRE 1858
Score = 519 bits (1336), Expect = e-145
Identities = 291/657 (44%), Positives = 376/657 (56%), Gaps = 17/657 (2%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N IRK I EW PFE++IL I ANCI LA+ Q P D + L+ E FI +
Sbjct: 73 DNVIRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGI 132
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KI+A+GF+FH +YLRN WN++DF++V+ G+++T + FD++ LRA R
Sbjct: 133 FCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTD-----FDLRTLRAVR 187
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQVVL +I++AM+PLL I LL+ F I+++AIIGLE + GK H TC
Sbjct: 188 VLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAIVMFAIIGLEFYMGKFHKTCFS 247
Query: 760 PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTT----WPGPNNGITNF 927
TG+ + PCG + +C S TT W GPN GITNF
Sbjct: 248 NKTGE--EVGDFPCGEEPPAR-----------------QCESGTTCREYWQGPNYGITNF 288
Query: 928 DNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSG 1107
DN A+LTVFQC+++EGWTD++Y NDA G W W+YF+ L+I+GSFF+LNLVLGVLSG
Sbjct: 289 DNILFAVLTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSG 348
Query: 1108 EFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDE--QEDEPVAQTX 1281
EF+KERE+ R F K R +QQ+E +L GYL+WI +AE++ ED+ +E P+
Sbjct: 349 EFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDKNAEEKSPLDMLK 408
Query: 1282 XXXXXXXX-----------XXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFY 1428
++ ++ +R EK+ +VK+Q+FY
Sbjct: 409 RAAIKKSKNDLIHAEEGSPFARASLKSGKNESSSYFRRKEKM---FRFFIRRMVKAQSFY 465
Query: 1429 WXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQ 1608
W HY Q E L A F+ LF EM LKMY LG Y S
Sbjct: 466 WIVLCVVALNTLCVAMVHYDQPEKLTTALYFAEFVFLGLFLTEMSLKMYGLGPRNYFHSS 525
Query: 1609 FNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXX 1788
FN FD V++ SI E + G+SVLR+ RLLRIFKVTKYW
Sbjct: 526 FNYFDFGVIVGSIFEVIWAAVKPGTSFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNS 585
Query: 1789 XXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGE 1968
GMQ+FGG+FNF + P NFDTF A+LTVFQILTGE
Sbjct: 586 MKSIISLLFLLFLFIVVFALLGMQLFGGQFNFRDE--TPTTNFDTFPAAILTVFQILTGE 643
Query: 1969 DWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLT 2139
DWN VMYHGIES GGV + G+ IY+IVL + GNY LLNVFLAIAVDNLA+A LT
Sbjct: 644 DWNAVMYHGIESQGGVHS-GMFSSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELT 699
Score = 177 bits (448), Expect = 3e-42
Identities = 163/672 (24%), Positives = 280/672 (41%), Gaps = 74/672 (11%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLFI S N R + + F +L I+ + +LA E L M L+
Sbjct: 66 SLFIFSEDNVIRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 125
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSL-----TSFVLRTDAM 2667
+ +F +F E +K+I G VFHKGS+ RN +N++D +VV + T F LRT
Sbjct: 126 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDFDLRT--- 182
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
++ L+ V++ ++ A+ + I L+ F MFAIIG++ +
Sbjct: 183 -----LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAIVMFAIIGLEFY 237
Query: 2848 KGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSK---KRVWSNNDF---NFDNVGDAM 3009
G F +K E G++ E+ + S + W ++ NFDN+ A+
Sbjct: 238 MGKFHKTCFSNKTGEEV--GDFPCGEEPPARQCESGTTCREYWQGPNYGITNFDNILFAV 295
Query: 3010 ISLFVVSTFEGWPQL------------------------------LYVAIDSNE--EDKG 3093
+++F T EGW + L + + S E +++
Sbjct: 296 LTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERE 355
Query: 3094 PIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIE-- 3267
+ N R + L V E + E LD +R I+
Sbjct: 356 RVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDKNAEEKSPLDMLKRAAIKKS 415
Query: 3268 -----FALKAKPHRR------------YIPRNRLQYRVWW--FVTSRAFEYVIFLIIVMN 3390
A + P R Y R +R + V +++F +++ ++ +N
Sbjct: 416 KNDLIHAEEGSPFARASLKSGKNESSSYFRRKEKMFRFFIRRMVKAQSFYWIVLCVVALN 475
Query: 3391 TVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVV 3570
T+ +A HY L +F G+F E LK+ L P+NY +N FD V+V
Sbjct: 476 TLCVAMVHYDQPEKLTTALYFAEFVFLGLFLTEMSLKMYGLGPRNYFHSSFNYFDFGVIV 535
Query: 3571 GSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVA 3750
GS ++ + + PG + I+ R R++R+ K+ +R L+ + + S +++ +
Sbjct: 536 GSIFEVIWAAVKPGTS--FGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLL 593
Query: 3751 LLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIML 3927
L+ L ++A++GMQ F G+ D T NF +FPAAIL +F+ TGE W +M
Sbjct: 594 FLLFLFIVVFALLGMQLFGGQFNFRDETP---TTNFDTFPAAILTVFQILTGEDWNAVM- 649
Query: 3928 SCSDREDVRCDPMSDDYH----KGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIM 4095
YH +GG++ F+ YFI + ++ ++N+F+A+ +
Sbjct: 650 ----------------YHGIESQGGVHSGM----FSSIYFIVLTLFGNYTLLNVFLAIAV 689
Query: 4096 DNF---DYLTRD 4122
DN LT+D
Sbjct: 690 DNLANAQELTKD 701
Score = 177 bits (448), Expect = 3e-42
Identities = 158/651 (24%), Positives = 276/651 (42%), Gaps = 20/651 (3%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR+L IV + FE +IL +I + IALA P A+ +N L+ ++Y+F VF
Sbjct: 1121 NPIRRLFHYIVNLRYFEMVILIVIALSSIALAAEDPVQAESP--RNDALKYLDYIFTGVF 1178
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD-VKALRAFR 579
T E V+K++ +G + HP +Y R+ WNILDFI+V LV+ S + + +K+LR R
Sbjct: 1179 TFEMVIKMIDLGLLLHPGSYFRDLWNILDFIVVSGALVAFAFSGTKGKDINTIKSLRVLR 1238
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF G+ C D
Sbjct: 1239 VLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGRFFY-CTD 1297
Query: 760 PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFG 939
+ + +KD D E + + QP + W+ ++DN
Sbjct: 1298 ES--KELEKDCRGQYLDYEKNEVEAQPRE--------WKKYE-----------FHYDNVL 1336
Query: 940 LAMLTVFQCVSLEGWTDVMYWVNDAVGREWP---------WIYFVTLVILGSFFVLNLVL 1092
A+LT+F + EGW V+ DA E I++V ++ FF +N+ +
Sbjct: 1337 WALLTLFTVSTGEGWPTVLKHSVDATYEEQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFV 1396
Query: 1093 GVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVA 1272
++ F ++ + K + LE++ + +D+ A+ +
Sbjct: 1397 ALIIITFQEQGD---------KVMSECSLEKNERACIDFAISAKPL-------------- 1433
Query: 1273 QTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXX 1452
P + ++ K V S F +
Sbjct: 1434 ----------------TRYMPQNKQSFQYKMWKF-----------VVSPPFEYFIMVMIA 1466
Query: 1453 XXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFV 1632
+ Y E + N+ F +FSME +LK+ + G Y +N FD
Sbjct: 1467 LNTIVLMMKFYDAPEAYEEMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVT 1526
Query: 1633 VISSILEFVLVYF-DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXX 1809
V+ SI + ++ D + +S LR R R+ K+ +
Sbjct: 1527 VLGSITDILVTEIADTDNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV 1586
Query: 1810 XXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMY 1989
GMQVFG + NF TF+QAL+ +F+ TGE W+ +M
Sbjct: 1587 CLLIAMLFFIYAIIGMQVFGNIALNDETSINRHNNFRTFLQALMLLFRSATGEAWHEIML 1646
Query: 1990 -----HGIESFGGV--GTLGVIVCIYYIV--LFICGNYILLNVFLAIAVDN 2115
+ G+ G +Y V +F+C ++++LN+F+A+ +DN
Sbjct: 1647 SCLSNRACDPLSGLTKNECGSDFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1696
Score = 95.9 bits (237), Expect = 1e-17
Identities = 77/316 (24%), Positives = 139/316 (43%), Gaps = 20/316 (6%)
Frame = +1
Query: 226 PIRKLCISIVEWK-----PFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVF 390
P K WK PFE+ I+ MI N I L + + Y A ++ +L+ + VF
Sbjct: 1438 PQNKQSFQYKMWKFVVSPPFEYFIMVMIALNTIVLMM-KFYDAPEA--YEEMLKCLNIVF 1494
Query: 391 IVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKA 564
+F++ECVLKI+A G + Y R+AWN+ DF+ V+ + ++++++ ++
Sbjct: 1495 TSMFSMECVLKIIAFGVL----NYFRDAWNVFDFVTVLGSITDILVTEIADTDNFINLSF 1550
Query: 565 LRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLH 744
LR FR R ++L+ +++++L +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1551 LRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF----- 1605
Query: 745 STCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITN 924
G +A D T N N
Sbjct: 1606 --------GNIALNDETSI------------------------------------NRHNN 1621
Query: 925 FDNFGLAMLTVFQCVSLEGWTDVMY-------------WVNDAVGREWPWIYFVTLVILG 1065
F F A++ +F+ + E W ++M + G ++ + YFV+ + L
Sbjct: 1622 FRTFLQALMLLFRSATGEAWHEIMLSCLSNRACDPLSGLTKNECGSDFAYFYFVSFIFLC 1681
Query: 1066 SFFVLNLVLGVLSGEF 1113
SF +LNL + V+ F
Sbjct: 1682 SFLMLNLFVAVIMDNF 1697
Score = 53.5 bits (127), Expect = 6e-05
Identities = 55/274 (20%), Positives = 108/274 (39%), Gaps = 3/274 (1%)
Frame = +1
Query: 2293 AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN 2472
A +++K SS + FR F +V F VL C++ + + A
Sbjct: 429 ARASLKSGKNESSSYFRRKEKMFRFFIRRMVKAQSFYWIVL-CVVALNTLCVAMVHYDQP 487
Query: 2473 STRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL 2652
L + ++ F +F E++LK+ G ++ ++FN D V+ S+ +
Sbjct: 488 EKLTTALYFAEFVFLGLFLTEMSLKMYGLG----PRNYFHSSFNYFDFGVIVGSIFEVIW 543
Query: 2653 RTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
K L+++V ++ ++K+I +++ + F+ +F
Sbjct: 544 AAVKPGTSFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVF 603
Query: 2824 AIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGD 3003
A++G+QLF G F ++ D PT NFD
Sbjct: 604 ALLGMQLFGGQF-------------------NFRDETPTT-------------NFDTFPA 631
Query: 3004 AMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHN 3105
A++++F + T E W ++Y I+S +G +H+
Sbjct: 632 AILTVFQILTGEDWNAVMYHGIES----QGGVHS 661
>gi|5802899|gb|AAD51821.1| N-type calcium channel alpha-1B cdB7
variant [Gallus gallus]
Length = 2332
Score = 679 bits (1753), Expect = 0.0
Identities = 357/766 (46%), Positives = 493/766 (63%), Gaps = 9/766 (1%)
Frame = +1
Query: 2308 KPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNM 2487
KPI SS+FILS TN R + +VN YF +L I +SS LAAEDP+QA S RN
Sbjct: 1117 KPILPYSSMFILSPTNPIRRLFHYIVNLRYFEMVILIVIALSSIALAAEDPVQAESPRND 1176
Query: 2488 ILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL---RT 2658
L Y DY FT VFT E+ +K+I GL+ H GS+ R+ +N+LD +VV+ +L +F +
Sbjct: 1177 ALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGSYFRDLWNILDFIVVSGALVAFAFSGTKG 1236
Query: 2659 DAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGV 2838
++ I R LK V CV+ ++K + NI++V + F+FA+I V
Sbjct: 1237 KDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAV 1296
Query: 2839 QLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISL 3018
QLFKG FF C D SK E +CRG+Y+ YE + ++ R W +F++DNV A+++L
Sbjct: 1297 QLFKGRFFYCTDESKELEKDCRGQYLDYEKNEVE---AQPREWKKYEFHYDNVLWALLTL 1353
Query: 3019 FVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIVT 3198
F VST EGWP +L ++D+ E++GP R +++ +I+T
Sbjct: 1354 FTVSTGEGWPTVLKHSVDATYEEQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIIT 1413
Query: 3199 FQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRAFEYVIF 3372
FQ +G++ C L+KN+R CI+FA+ AKP RY+P+N+ QY++W FV S FEY I
Sbjct: 1414 FQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNKQSFQYKMWKFVVSPPFEYFIM 1473
Query: 3373 LIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVF 3552
++I +NT+ L K Y + +E+ L N++FT +F+ E VLKI+A NY D WNVF
Sbjct: 1474 VMIALNTIVLMMKFYDAPEAYEEMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVF 1533
Query: 3553 DLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQ 3732
D + V+GS DI ++ N I+++F RLFR RL+KLL +G IR LLWTF++SF+
Sbjct: 1534 DFVTVLGSITDILVTEI-ADTDNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFK 1592
Query: 3733 ALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAW 3912
ALPYV LLI +LFFIYA+IGMQ FG +AL+D TSI+R+NNF +F A+++LFRSATGEAW
Sbjct: 1593 ALPYVCLLIAMLFFIYAIIGMQVFGNIALNDETSINRHNNFRTFLQALMLLFRSATGEAW 1652
Query: 3913 QDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVI 4092
+IMLSC CDP+S GL ++ CG++FAY YF+SF LCSFL++NLFVAVI
Sbjct: 1653 HEIMLSCLSNR--ACDPLS------GLTKNECGSDFAYFYFVSFIFLCSFLMLNLFVAVI 1704
Query: 4093 MDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCP 4272
MDNF+YLTRD SILGPHHL+EFVR+W+EYDP A RI + D+ LLR I+PPLG GK CP
Sbjct: 1705 MDNFEYLTRDSSILGPHHLDEFVRVWAEYDPAACCRIHYKDMYNLLRVIAPPLGLGKKCP 1764
Query: 4273 HRLACKRLVSMNMPLN-SDGTVCFNATLFALVRTNLKI-YTEGNI--DEANEQLRSAIKR 4440
HR+A KRLV MNMP++ D TV F +TL AL+RT L+I G + + + +LR I
Sbjct: 1765 HRVAYKRLVRMNMPISPEDLTVHFTSTLMALIRTALEIKLASGGVKQHQCDAELRKEISL 1824
Query: 4441 IWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKE 4578
+W + LD +VPP K D++TVGK YA +I D++++ K +E
Sbjct: 1825 VWPNLSQKTLDLLVPP-HKPDEMTVGKVYAALMIFDFYKQNKSSRE 1869
Score = 514 bits (1325), Expect = e-144
Identities = 291/668 (43%), Positives = 376/668 (55%), Gaps = 28/668 (4%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N IRK I EW PFE++IL I ANCI LA+ Q P D + L+ E FI +
Sbjct: 73 DNVIRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGI 132
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KI+A+GF+FH +YLRN WN++DF++V+ G+++T + FD++ LRA R
Sbjct: 133 FCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTD-----FDLRTLRAVR 187
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQVVL +I++AM+PLL I LL+ F I+++AIIGLE + GK H TC
Sbjct: 188 VLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAIVMFAIIGLEFYMGKFHKTCFS 247
Query: 760 PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTT----WPGPNNGITNF 927
TG+ + PCG + +C S TT W GPN GITNF
Sbjct: 248 NKTGE--EVGDFPCGEEPPAR-----------------QCESGTTCREYWQGPNYGITNF 288
Query: 928 DNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSG 1107
DN A+LTVFQC+++EGWTD++Y NDA G W W+YF+ L+I+GSFF+LNLVLGVLSG
Sbjct: 289 DNILFAVLTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSG 348
Query: 1108 EFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDE--QEDEPVAQTX 1281
EF+KERE+ R F K R +QQ+E +L GYL+WI +AE++ ED+ +E P+
Sbjct: 349 EFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDKNAEEKSPLDMLK 408
Query: 1282 XXX----------------------XXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXX 1395
++ ++ +R EK+
Sbjct: 409 RAAIKKSKNDLIHAEEGEDHFTDICSVGSPFARASLKSGKNESSSYFRRKEKM---FRFF 465
Query: 1396 XXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMY 1575
+VK+Q+FYW HY Q E L A F+ LF EM LKMY
Sbjct: 466 IRRMVKAQSFYWIVLCVVALNTLCVAMVHYDQPEKLTTALYFAEFVFLGLFLTEMSLKMY 525
Query: 1576 SLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTX 1755
LG Y S FN FD V++ SI E + G+SVLR+ RLLRIFKVTKYW
Sbjct: 526 GLGPRNYFHSSFNYFDFGVIVGSIFEVIWAAVKPGTSFGISVLRALRLLRIFKVTKYWNS 585
Query: 1756 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQA 1935
GMQ+FGG+FNF + P NFDTF A
Sbjct: 586 LRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFRDE--TPTTNFDTFPAA 643
Query: 1936 LLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDN 2115
+LTVFQILTGEDWN VMYHGIES GGV + G+ IY+IVL + GNY LLNVFLAIAVDN
Sbjct: 644 ILTVFQILTGEDWNAVMYHGIESQGGVHS-GMFSSIYFIVLTLFGNYTLLNVFLAIAVDN 702
Query: 2116 LADADSLT 2139
LA+A LT
Sbjct: 703 LANAQELT 710
Score = 177 bits (448), Expect = 3e-42
Identities = 158/651 (24%), Positives = 276/651 (42%), Gaps = 20/651 (3%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR+L IV + FE +IL +I + IALA P A+ +N L+ ++Y+F VF
Sbjct: 1132 NPIRRLFHYIVNLRYFEMVILIVIALSSIALAAEDPVQAESP--RNDALKYLDYIFTGVF 1189
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD-VKALRAFR 579
T E V+K++ +G + HP +Y R+ WNILDFI+V LV+ S + + +K+LR R
Sbjct: 1190 TFEMVIKMIDLGLLLHPGSYFRDLWNILDFIVVSGALVAFAFSGTKGKDINTIKSLRVLR 1249
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF G+ C D
Sbjct: 1250 VLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGRFFY-CTD 1308
Query: 760 PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFG 939
+ + +KD D E + + QP + W+ ++DN
Sbjct: 1309 ES--KELEKDCRGQYLDYEKNEVEAQPRE--------WKKYE-----------FHYDNVL 1347
Query: 940 LAMLTVFQCVSLEGWTDVMYWVNDAVGREWP---------WIYFVTLVILGSFFVLNLVL 1092
A+LT+F + EGW V+ DA E I++V ++ FF +N+ +
Sbjct: 1348 WALLTLFTVSTGEGWPTVLKHSVDATYEEQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFV 1407
Query: 1093 GVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVA 1272
++ F ++ + K + LE++ + +D+ A+ +
Sbjct: 1408 ALIIITFQEQGD---------KVMSECSLEKNERACIDFAISAKPL-------------- 1444
Query: 1273 QTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXX 1452
P + ++ K V S F +
Sbjct: 1445 ----------------TRYMPQNKQSFQYKMWKF-----------VVSPPFEYFIMVMIA 1477
Query: 1453 XXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFV 1632
+ Y E + N+ F +FSME +LK+ + G Y +N FD
Sbjct: 1478 LNTIVLMMKFYDAPEAYEEMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVT 1537
Query: 1633 VISSILEFVLVYF-DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXX 1809
V+ SI + ++ D + +S LR R R+ K+ +
Sbjct: 1538 VLGSITDILVTEIADTDNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV 1597
Query: 1810 XXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMY 1989
GMQVFG + NF TF+QAL+ +F+ TGE W+ +M
Sbjct: 1598 CLLIAMLFFIYAIIGMQVFGNIALNDETSINRHNNFRTFLQALMLLFRSATGEAWHEIML 1657
Query: 1990 -----HGIESFGGV--GTLGVIVCIYYIV--LFICGNYILLNVFLAIAVDN 2115
+ G+ G +Y V +F+C ++++LN+F+A+ +DN
Sbjct: 1658 SCLSNRACDPLSGLTKNECGSDFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1707
Score = 122 bits (306), Expect = 1e-25
Identities = 81/293 (27%), Positives = 141/293 (47%), Gaps = 8/293 (2%)
Frame = +1
Query: 3268 FALKAKPHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFL 3447
F K K R +I R V +++F +++ ++ +NT+ +A HY L
Sbjct: 455 FRRKEKMFRFFIRR---------MVKAQSFYWIVLCVVALNTLCVAMVHYDQPEKLTTAL 505
Query: 3448 DVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLI 3627
+F G+F E LK+ L P+NY +N FD V+VGS ++ + + PG +
Sbjct: 506 YFAEFVFLGLFLTEMSLKMYGLGPRNYFHSSFNYFDFGVIVGSIFEVIWAAVKPGTS--F 563
Query: 3628 SINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF- 3804
I+ R R++R+ K+ +R L+ + + S +++ + L+ L ++A++GMQ F
Sbjct: 564 GISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFG 623
Query: 3805 GKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYH- 3981
G+ D T NF +FPAAIL +F+ TGE W +M YH
Sbjct: 624 GQFNFRDETP---TTNFDTFPAAILTVFQILTGEDWNAVM-----------------YHG 663
Query: 3982 ---KGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF---DYLTRD 4122
+GG++ F+ YFI + ++ ++N+F+A+ +DN LT+D
Sbjct: 664 IESQGGVHSGM----FSSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 712
Score = 95.9 bits (237), Expect = 1e-17
Identities = 77/316 (24%), Positives = 139/316 (43%), Gaps = 20/316 (6%)
Frame = +1
Query: 226 PIRKLCISIVEWK-----PFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVF 390
P K WK PFE+ I+ MI N I L + + Y A ++ +L+ + VF
Sbjct: 1449 PQNKQSFQYKMWKFVVSPPFEYFIMVMIALNTIVLMM-KFYDAPEA--YEEMLKCLNIVF 1505
Query: 391 IVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKA 564
+F++ECVLKI+A G + Y R+AWN+ DF+ V+ + ++++++ ++
Sbjct: 1506 TSMFSMECVLKIIAFGVL----NYFRDAWNVFDFVTVLGSITDILVTEIADTDNFINLSF 1561
Query: 565 LRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLH 744
LR FR R ++L+ +++++L +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1562 LRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF----- 1616
Query: 745 STCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITN 924
G +A D T N N
Sbjct: 1617 --------GNIALNDETSI------------------------------------NRHNN 1632
Query: 925 FDNFGLAMLTVFQCVSLEGWTDVMY-------------WVNDAVGREWPWIYFVTLVILG 1065
F F A++ +F+ + E W ++M + G ++ + YFV+ + L
Sbjct: 1633 FRTFLQALMLLFRSATGEAWHEIMLSCLSNRACDPLSGLTKNECGSDFAYFYFVSFIFLC 1692
Query: 1066 SFFVLNLVLGVLSGEF 1113
SF +LNL + V+ F
Sbjct: 1693 SFLMLNLFVAVIMDNF 1708
Score = 88.2 bits (217), Expect = 2e-15
Identities = 73/263 (27%), Positives = 119/263 (44%), Gaps = 14/263 (5%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLFI S N R + + F +L I+ + +LA E L M L+
Sbjct: 66 SLFIFSEDNVIRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 125
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV-----AVSLTSFVLRTDAM 2667
+ +F +F E +K+I G VFHKGS+ RN +N++D +VV A + T F LRT
Sbjct: 126 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDFDLRT--- 182
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
++ L+ V++ ++ A+ + I L+ F MFAIIG++ +
Sbjct: 183 -----LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAIVMFAIIGLEFY 237
Query: 2848 KGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSK----KRVWSNNDF---NFDNVGDA 3006
G F +K E G++ E+ P + + W ++ NFDN+ A
Sbjct: 238 MGKFHKTCFSNKTGEEV--GDFPCGEE-PPARQCESGTTCREYWQGPNYGITNFDNILFA 294
Query: 3007 MISLFVVSTFEGWPQLLYVAIDS 3075
++++F T EGW +LY D+
Sbjct: 295 VLTVFQCITMEGWTDILYNTNDA 317
Score = 85.9 bits (211), Expect = 1e-14
Identities = 75/291 (25%), Positives = 123/291 (41%), Gaps = 41/291 (14%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY+I I+ N + LA + H P + LD F G+F FEA +KI+AL
Sbjct: 89 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 148
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WNV D +VV+ G L GT+ + R RV+R +KL+S
Sbjct: 149 HKGSYLRNGWNVMDFVVVL-------TGILATAGTD-FDLRTLRAVRVLRPLKLVSGIPS 200
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQF----FGKVALDDSTSIHRNN---- 3849
++ +L + MK+ L + LL+ ++A+IG++F F K + T +
Sbjct: 201 LQVVLKSIMKAMVPLLQIGLLLFFAIVMFAIIGLEFYMGKFHKTCFSNKTGEEVGDFPCG 260
Query: 3850 --------------------------NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDV 3951
NF + A+L +F+ T E W DI+ + +D
Sbjct: 261 EEPPARQCESGTTCREYWQGPNYGITNFDNILFAVLTVFQCITMEGWTDILYNTND---- 316
Query: 3952 RCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
GN + + YFI ++ SF ++NL + V+ F
Sbjct: 317 -----------------AAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 350
Score = 53.5 bits (127), Expect = 6e-05
Identities = 55/274 (20%), Positives = 108/274 (39%), Gaps = 3/274 (1%)
Frame = +1
Query: 2293 AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN 2472
A +++K SS + FR F +V F VL C++ + + A
Sbjct: 440 ARASLKSGKNESSSYFRRKEKMFRFFIRRMVKAQSFYWIVL-CVVALNTLCVAMVHYDQP 498
Query: 2473 STRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL 2652
L + ++ F +F E++LK+ G ++ ++FN D V+ S+ +
Sbjct: 499 EKLTTALYFAEFVFLGLFLTEMSLKMYGLG----PRNYFHSSFNYFDFGVIVGSIFEVIW 554
Query: 2653 RTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
K L+++V ++ ++K+I +++ + F+ +F
Sbjct: 555 AAVKPGTSFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVF 614
Query: 2824 AIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGD 3003
A++G+QLF G F ++ D PT NFD
Sbjct: 615 ALLGMQLFGGQF-------------------NFRDETPTT-------------NFDTFPA 642
Query: 3004 AMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHN 3105
A++++F + T E W ++Y I+S +G +H+
Sbjct: 643 AILTVFQILTGEDWNAVMYHGIES----QGGVHS 672
>gi|13386500|ref|NP_000059.2| calcium channel, alpha 1A subunit
isoform 1; calcium channel, L type, alpha-1 polypeptide,
isoform 4; brain calcium channel 1 [Homo sapiens]
Length = 2261
Score = 679 bits (1752), Expect = 0.0
Identities = 408/1021 (39%), Positives = 571/1021 (54%), Gaps = 62/1021 (6%)
Frame = +1
Query: 2308 KPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNM 2487
KP+P SS+FILS TN R C+ ++N YF +L I +SS LAAEDP+Q N+ RN
Sbjct: 1216 KPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNN 1275
Query: 2488 ILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDA- 2664
+L YFDY FT VFT E+ +K+I GLV H+G++ R+ +N+LD +VV+ +L +F ++
Sbjct: 1276 VLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSK 1335
Query: 2665 ---MSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIG 2835
++ I R LK V CV+ ++K + NI++V + F+FA++
Sbjct: 1336 GKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVA 1395
Query: 2836 VQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMIS 3015
VQLFKG FF C D SK E +CRG+Y+ YE + ++ R W +F++DNV A+++
Sbjct: 1396 VQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVK---ARDREWKKYEFHYDNVLWALLT 1452
Query: 3016 LFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIV 3195
LF VST EGWPQ+L ++D+ E++GP R +++ +I+
Sbjct: 1453 LFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIII 1512
Query: 3196 TFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRAFEYVI 3369
TFQ +G++ E L+KN+R CI+FA+ AKP R++P+N+ QYR+W FV S FEY I
Sbjct: 1513 TFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTI 1572
Query: 3370 FLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNV 3549
+I +NT+ L K Y +S +E+ L VFN++FT +F+ E VLK++A NY D WN+
Sbjct: 1573 MAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNI 1632
Query: 3550 FDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSF 3729
FD + V+GS DI + G N I+++F RLFR RL+KLL +G IR LLWTF++SF
Sbjct: 1633 FDFVTVLGSITDILVTEF---GNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSF 1689
Query: 3730 QALPYVALLIVLLFFIYAVIGMQFFGKVALD--------DSTSIHRNNNFHSFPAAILVL 3885
+ALPYV LLI +LFFIYA+IGMQ FG + +D D I +NNF +F A+++L
Sbjct: 1690 KALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLL 1749
Query: 3886 FRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFL 4065
FRSATGEAW +IMLSC + CD S G+ CGN FAY YF+SF LCSFL
Sbjct: 1750 FRSATGEAWHNIMLSCLSGKP--CDKNS------GILTRECGNEFAYFYFVSFIFLCSFL 1801
Query: 4066 VINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
++NLFVAVIMDNF+YLTRD SILGPHHL+E+VR+W+EYDP A GRI + D+ +LLR ISP
Sbjct: 1802 MLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAACGRIHYKDMYSLLRVISP 1861
Query: 4246 PLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKI-YTEGNID--EANE 4416
PLG GK CPHR+ACKRL+ M++P+ D TV FN+TL AL+RT L I +G D + +
Sbjct: 1862 PLGLGKKCPHRVACKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDA 1921
Query: 4417 QLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRK------- 4575
+LR + IW + LD +V P K D+TVGK YA +I +Y+R+ K +K
Sbjct: 1922 ELRKEMMAIWPNLSQKTLDLLVTP-HKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAMREE 1980
Query: 4576 ---------EMEAKGVLPAQTPQAMALQA------GLRTLHEIGPE------LKRAISGN 4692
ME P AL + G HE G + +RA
Sbjct: 1981 QDRTPLMFQRMEPPSPTQEGGPGQNALPSTQLDPGGALMAHESGLKESPSWVTQRAQEMF 2040
Query: 4693 LETDFNFDEPEPQHRRPHSLFN--NLVHRLSGAGSKSPTEHERIEKGSTLLPFQPRSFSP 4866
+T E P P+S N ++ R G S +EH +G PR +
Sbjct: 2041 QKTGTWSPEQGPPTDMPNSQPNSQSVEMREMGRDGYSDSEHYLPMEGQGRAASMPRLPAE 2100
Query: 4867 THSLAGAEGSPVPSQMHRGAPINQSINLPPVNGSARR-----LPALPPYANHIHDETDDG 5031
G S + +P+ +S ++ + ARR L +PP N H +
Sbjct: 2101 NQRRRGRPRGNNLSTISDTSPMKRSASV--LGPKARRLDDYSLERVPPEENQRHHQ---- 2154
Query: 5032 PRYRDTGDRAGYDQSSRMVVANRNLPVD----------PDEEEQWMRSGGPSNRSDRRNP 5181
R RD RA R + L D P +E R G P +R R++
Sbjct: 2155 -RRRDRSHRASERSLGRYTDVDTGLGTDLSMTTQSGDLPSKERDQER-GRPKDRKHRQHH 2212
Query: 5182 H 5184
H
Sbjct: 2213 H 2213
Score = 536 bits (1381), Expect = e-150
Identities = 295/667 (44%), Positives = 383/667 (57%), Gaps = 27/667 (4%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N +RK I EW PFE++IL I ANCI LA+ Q P D + L+ E FI +
Sbjct: 84 DNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGI 143
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KI+A+GF FH +YLRN WN++DF++V+ G+++T+ ++ FD++ LRA R
Sbjct: 144 FCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE-----FDLRTLRAVR 198
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQVVL +I++AMIPLL I LL+ F ILI+AIIGLE + GK H+TC +
Sbjct: 199 VLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFE 258
Query: 760 PATGQLAQKDPTPCGTD----TEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNF 927
T + + P PCGT+ T + KCQP W GPNNGIT F
Sbjct: 259 EGTDDIQGESPAPCGTEEPARTCPNGTKCQPY-----------------WEGPNNGITQF 301
Query: 928 DNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSG 1107
DN A+LTVFQC+++EGWTD++Y NDA G W W+YF+ L+I+GSFF+LNLVLGVLSG
Sbjct: 302 DNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSG 361
Query: 1108 EFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVAQTXXX 1287
EF+KERE+ R F K R +QQ+E +L GY++WI++AE++ + EDE + E
Sbjct: 362 EFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEV-ILAEDETDGEQRHPFDGA 420
Query: 1288 XXXXXXXXXXXXXXXP-----------------SKWAARMKRLE------KLNXXXXXXX 1398
P ++ + + +LE K
Sbjct: 421 LRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFYI 480
Query: 1399 XXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYS 1578
+VK+Q FYW HY Q EWL F A F+ LF EM +KMY
Sbjct: 481 RRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYG 540
Query: 1579 LGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXX 1758
LG Y S FN FDC V+I SI E + G+SVLR+ RLLRIFKVTKYW
Sbjct: 541 LGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASL 600
Query: 1759 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQAL 1938
GMQ+FGG+FNF+ + P NFDTF A+
Sbjct: 601 RNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFD--EGTPPTNFDTFPAAI 658
Query: 1939 LTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNL 2118
+TVFQILTGEDWN VMY GI+S GGV G++ IY+IVL + GNY LLNVFLAIAVDNL
Sbjct: 659 MTVFQILTGEDWNEVMYDGIKSQGGVQG-GMVFSIYFIVLTLFGNYTLLNVFLAIAVDNL 717
Query: 2119 ADADSLT 2139
A+A LT
Sbjct: 718 ANAQELT 724
Score = 168 bits (426), Expect = 1e-39
Identities = 159/660 (24%), Positives = 278/660 (42%), Gaps = 29/660 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+R+LC I+ + FE IL +I + IALA P Q + +N +L +YVF VF
Sbjct: 1231 NPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDP--VQPNAPRNNVLRYFDYVFTGVF 1288
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD---VKALRA 573
T E V+K++ +G + H AY R+ WNILDFI+V LV+ + S +G D +K+LR
Sbjct: 1289 TFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNS-KGKDINTIKSLRV 1347
Query: 574 FRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTC 753
RVLRPL+ + +P L+ V + ++ ++ + +I ++ + + I+A++ ++LF GK C
Sbjct: 1348 LRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFH-C 1406
Query: 754 IDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDN 933
D + + +KD E + K + + W+ ++DN
Sbjct: 1407 TDES--KEFEKDCRGKYLLYEKNEVKARDRE--------WKKYE-----------FHYDN 1445
Query: 934 FGLAMLTVFQCVSLEGWTDVMYWVNDAV---------GREWPWIYFVTLVILGSFFVLNL 1086
A+LT+F + EGW V+ DA R I++V ++ FF +N+
Sbjct: 1446 VLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNI 1505
Query: 1087 VLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEP 1266
+ ++ F ++ + K E+ LE++ + +D+ A+ +
Sbjct: 1506 FVALIIITFQEQGD---------KMMEEYSLEKNERACIDFAISAKPL------------ 1544
Query: 1267 VAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXX 1446
+ + + V S F +
Sbjct: 1545 -----------------------------TRHMPQNKQSFQYRMWQFVVSPPFEYTIMAM 1575
Query: 1447 XXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDC 1626
+ YG S ++ + N+ F LFS+E +LK+ + G Y +N FD
Sbjct: 1576 IALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDF 1635
Query: 1627 FVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXX 1806
V+ SI + ++ F + +S LR R R+ K+ +
Sbjct: 1636 VTVLGSITDILVTEFG-NNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPY 1694
Query: 1807 XXXXXXXXXXXXXXXGMQVFGG--------KFNFNPQQPKPRANFDTFVQALLTVFQILT 1962
GMQVFG + + Q NF TF QAL+ +F+ T
Sbjct: 1695 VCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSAT 1754
Query: 1963 GEDWNTVMYHGI-----ESFGGVGT--LGVIVCIYYIV--LFICGNYILLNVFLAIAVDN 2115
GE W+ +M + + G+ T G +Y V +F+C ++++LN+F+A+ +DN
Sbjct: 1755 GEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1813
Score = 120 bits (300), Expect = 5e-25
Identities = 73/274 (26%), Positives = 139/274 (50%), Gaps = 4/274 (1%)
Frame = +1
Query: 3313 RLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEA 3492
R+++ + V ++AF + + ++ +NT+ +A HY DFL IF G+F E
Sbjct: 475 RMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEM 534
Query: 3493 VLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVK 3672
+K+ L + Y +N FD V++GS ++ + + PG + I+ R R++R+ K
Sbjct: 535 FIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTS--FGISVLRALRLLRIFK 592
Query: 3673 LLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNN 3849
+ +R L+ + + S +++ + L+ L ++A++GMQ F G+ D+ T
Sbjct: 593 VTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTP---PT 649
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FPAAI+ +F+ TGE W ++M + ++ +GG+ G
Sbjct: 650 NFDTFPAAIMTVFQILTGEDWNEVMY-----DGIK--------SQGGVQ----GGMVFSI 692
Query: 4030 YFISFFMLCSFLVINLFVAVIMDNF---DYLTRD 4122
YFI + ++ ++N+F+A+ +DN LT+D
Sbjct: 693 YFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 726
Score = 95.5 bits (236), Expect = 1e-17
Identities = 73/296 (24%), Positives = 130/296 (43%), Gaps = 13/296 (4%)
Frame = +1
Query: 265 PFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFM 444
PFE+ I+ MI N I L + + Y+N L VF +F++ECVLK++A G +
Sbjct: 1567 PFEYTIMAMIALNTIVLMM--KFYGASVAYENAL-RVFNIVFTSLFSLECVLKVMAFGIL 1623
Query: 445 FHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQ 624
Y R+AWNI DF+ V+ + ++++ ++ LR FR R ++L+ +++
Sbjct: 1624 ----NYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIR 1679
Query: 625 VVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCG 804
++L +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1680 ILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF------------------------- 1714
Query: 805 TDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGW 984
N+G+ E + NF F A++ +F+ + E W
Sbjct: 1715 ----------------GNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAW 1758
Query: 985 TDVMYWV--------NDAV-----GREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
++M N + G E+ + YFV+ + L SF +LNL + V+ F
Sbjct: 1759 HNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1814
Score = 86.7 bits (213), Expect = 6e-15
Identities = 70/263 (26%), Positives = 117/263 (43%), Gaps = 13/263 (4%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLF+ S N R + + F +L I+ + +LA E L + M L+
Sbjct: 77 SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSL-----TSFVLRTDAM 2667
+ +F +F E +K+I G FHKGS+ RN +N++D +VV + T F LRT
Sbjct: 137 EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRT--- 193
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
++ L+ V++ ++ A+ + I L+ F +FAIIG++ +
Sbjct: 194 -----LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFY 248
Query: 2848 KGTFFL------CNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAM 3009
G F +D+ + A C E + TK +N FDN+ A+
Sbjct: 249 MGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAV 308
Query: 3010 ISLFVVSTFEGWPQLLYVAIDSN 3078
+++F T EGW LLY + D++
Sbjct: 309 LTVFQCITMEGWTDLLYNSNDAS 331
Score = 80.9 bits (198), Expect = 3e-13
Identities = 75/293 (25%), Positives = 123/293 (41%), Gaps = 43/293 (14%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY+I I+ N + LA + H P + LD F G+F FEA +KI+AL
Sbjct: 100 FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WNV D +VV+ G L GT + R RV+R +KL+S
Sbjct: 160 HKGSYLRNGWNVMDFVVVL-------TGILATVGTE-FDLRTLRAVRVLRPLKLVSGIPS 211
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQF----FGKVALDDSTSIHR------ 3843
++ +L + MK+ L + LL+ I+A+IG++F F ++ T +
Sbjct: 212 LQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAP 271
Query: 3844 -----------------------NN---NFHSFPAAILVLFRSATGEAWQDIMLSCSDRE 3945
NN F + A+L +F+ T E W D++ + +D
Sbjct: 272 CGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDAS 331
Query: 3946 DVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
GN + + YFI ++ SF ++NL + V+ F
Sbjct: 332 ---------------------GNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 363
Score = 75.9 bits (185), Expect = 1e-11
Identities = 72/322 (22%), Positives = 140/322 (43%), Gaps = 16/322 (4%)
Frame = +1
Query: 250 IVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIV 429
+V+ + F + +L ++ N + +AI ++ + L E++F+ +F E +K+
Sbjct: 483 MVKTQAFYWTVLSLVALNTLCVAIVH---YNQPEWLSDFLYYAEFIFLGLFMSEMFIKMY 539
Query: 430 AMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKALRAFRVLRPLRLV 603
+G Y +++N D V+IG + ++ + G F + LRA R+LR ++
Sbjct: 540 GLG----TRPYFHSSFNCFD-CGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVT 594
Query: 604 SGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ 783
SL+ ++ ++L +M ++ + L+ I+++A++G++LF GQ
Sbjct: 595 KYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLF------------GGQFNF 642
Query: 784 KDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQ 963
+ TP TNFD F A++TVFQ
Sbjct: 643 DEGTPP---------------------------------------TNFDTFPAAIMTVFQ 663
Query: 964 CVSLEGWTDVMY-WVNDAVGREWPW---IYFVTLVILGSFFVLNLVLGV----------L 1101
++ E W +VMY + G + IYF+ L + G++ +LN+ L + L
Sbjct: 664 ILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQEL 723
Query: 1102 SGEFSKEREKARARGLFQKFRE 1167
+ + +E E A + QK +E
Sbjct: 724 TKDEQEEEEAANQKLALQKAKE 745
Score = 46.2 bits (108), Expect = 0.009
Identities = 50/264 (18%), Positives = 103/264 (38%), Gaps = 3/264 (1%)
Frame = +1
Query: 2293 AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN 2472
A +++K +S F R + +V F VL + +++ +A Q
Sbjct: 454 ARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPE 513
Query: 2473 STRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL 2652
+ L Y ++ F +F E+ +K+ G + ++FN D V+ S+ +
Sbjct: 514 WLSDF-LYYAEFIFLGLFMSEMFIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIW 568
Query: 2653 RTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
K L+++V ++ ++K+I +++ + F+ +F
Sbjct: 569 AVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
Query: 2824 AIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGD 3003
A++G+QLF G F ++++G P NFD
Sbjct: 629 ALLGMQLFGGQF-------------------NFDEGTPPT-------------NFDTFPA 656
Query: 3004 AMISLFVVSTFEGWPQLLYVAIDS 3075
A++++F + T E W +++Y I S
Sbjct: 657 AIMTVFQILTGEDWNEVMYDGIKS 680
>gi|13386498|ref|NP_075461.1| calcium channel, alpha 1A subunit
isoform 2; calcium channel, L type, alpha-1 polypeptide,
isoform 4; brain calcium channel 1 [Homo sapiens]
gi|2281752|gb|AAB64179.1| alpha1A-voltage-dependent calcium channel
[Homo sapiens]
Length = 2505
Score = 679 bits (1752), Expect = 0.0
Identities = 408/1021 (39%), Positives = 571/1021 (54%), Gaps = 62/1021 (6%)
Frame = +1
Query: 2308 KPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNM 2487
KP+P SS+FILS TN R C+ ++N YF +L I +SS LAAEDP+Q N+ RN
Sbjct: 1216 KPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNN 1275
Query: 2488 ILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDA- 2664
+L YFDY FT VFT E+ +K+I GLV H+G++ R+ +N+LD +VV+ +L +F ++
Sbjct: 1276 VLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSK 1335
Query: 2665 ---MSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIG 2835
++ I R LK V CV+ ++K + NI++V + F+FA++
Sbjct: 1336 GKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVA 1395
Query: 2836 VQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMIS 3015
VQLFKG FF C D SK E +CRG+Y+ YE + ++ R W +F++DNV A+++
Sbjct: 1396 VQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVK---ARDREWKKYEFHYDNVLWALLT 1452
Query: 3016 LFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIV 3195
LF VST EGWPQ+L ++D+ E++GP R +++ +I+
Sbjct: 1453 LFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIII 1512
Query: 3196 TFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRAFEYVI 3369
TFQ +G++ E L+KN+R CI+FA+ AKP R++P+N+ QYR+W FV S FEY I
Sbjct: 1513 TFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTI 1572
Query: 3370 FLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNV 3549
+I +NT+ L K Y +S +E+ L VFN++FT +F+ E VLK++A NY D WN+
Sbjct: 1573 MAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNI 1632
Query: 3550 FDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSF 3729
FD + V+GS DI + G N I+++F RLFR RL+KLL +G IR LLWTF++SF
Sbjct: 1633 FDFVTVLGSITDILVTEF---GNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSF 1689
Query: 3730 QALPYVALLIVLLFFIYAVIGMQFFGKVALD--------DSTSIHRNNNFHSFPAAILVL 3885
+ALPYV LLI +LFFIYA+IGMQ FG + +D D I +NNF +F A+++L
Sbjct: 1690 KALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLL 1749
Query: 3886 FRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFL 4065
FRSATGEAW +IMLSC + CD S G+ CGN FAY YF+SF LCSFL
Sbjct: 1750 FRSATGEAWHNIMLSCLSGKP--CDKNS------GILTRECGNEFAYFYFVSFIFLCSFL 1801
Query: 4066 VINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
++NLFVAVIMDNF+YLTRD SILGPHHL+E+VR+W+EYDP A GRI + D+ +LLR ISP
Sbjct: 1802 MLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAACGRIHYKDMYSLLRVISP 1861
Query: 4246 PLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKI-YTEGNID--EANE 4416
PLG GK CPHR+ACKRL+ M++P+ D TV FN+TL AL+RT L I +G D + +
Sbjct: 1862 PLGLGKKCPHRVACKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDA 1921
Query: 4417 QLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRK------- 4575
+LR + IW + LD +V P K D+TVGK YA +I +Y+R+ K +K
Sbjct: 1922 ELRKEMMAIWPNLSQKTLDLLVTP-HKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAMREE 1980
Query: 4576 ---------EMEAKGVLPAQTPQAMALQA------GLRTLHEIGPE------LKRAISGN 4692
ME P AL + G HE G + +RA
Sbjct: 1981 QDRTPLMFQRMEPPSPTQEGGPGQNALPSTQLDPGGALMAHESGLKESPSWVTQRAQEMF 2040
Query: 4693 LETDFNFDEPEPQHRRPHSLFN--NLVHRLSGAGSKSPTEHERIEKGSTLLPFQPRSFSP 4866
+T E P P+S N ++ R G S +EH +G PR +
Sbjct: 2041 QKTGTWSPEQGPPTDMPNSQPNSQSVEMREMGRDGYSDSEHYLPMEGQGRAASMPRLPAE 2100
Query: 4867 THSLAGAEGSPVPSQMHRGAPINQSINLPPVNGSARR-----LPALPPYANHIHDETDDG 5031
G S + +P+ +S ++ + ARR L +PP N H +
Sbjct: 2101 NQRRRGRPRGNNLSTISDTSPMKRSASV--LGPKARRLDDYSLERVPPEENQRHHQ---- 2154
Query: 5032 PRYRDTGDRAGYDQSSRMVVANRNLPVD----------PDEEEQWMRSGGPSNRSDRRNP 5181
R RD RA R + L D P +E R G P +R R++
Sbjct: 2155 -RRRDRSHRASERSLGRYTDVDTGLGTDLSMTTQSGDLPSKERDQER-GRPKDRKHRQHH 2212
Query: 5182 H 5184
H
Sbjct: 2213 H 2213
Score = 536 bits (1381), Expect = e-150
Identities = 295/667 (44%), Positives = 383/667 (57%), Gaps = 27/667 (4%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N +RK I EW PFE++IL I ANCI LA+ Q P D + L+ E FI +
Sbjct: 84 DNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGI 143
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KI+A+GF FH +YLRN WN++DF++V+ G+++T+ ++ FD++ LRA R
Sbjct: 144 FCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE-----FDLRTLRAVR 198
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQVVL +I++AMIPLL I LL+ F ILI+AIIGLE + GK H+TC +
Sbjct: 199 VLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFE 258
Query: 760 PATGQLAQKDPTPCGTD----TEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNF 927
T + + P PCGT+ T + KCQP W GPNNGIT F
Sbjct: 259 EGTDDIQGESPAPCGTEEPARTCPNGTKCQPY-----------------WEGPNNGITQF 301
Query: 928 DNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSG 1107
DN A+LTVFQC+++EGWTD++Y NDA G W W+YF+ L+I+GSFF+LNLVLGVLSG
Sbjct: 302 DNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSG 361
Query: 1108 EFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVAQTXXX 1287
EF+KERE+ R F K R +QQ+E +L GY++WI++AE++ + EDE + E
Sbjct: 362 EFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEV-ILAEDETDGEQRHPFDGA 420
Query: 1288 XXXXXXXXXXXXXXXP-----------------SKWAARMKRLE------KLNXXXXXXX 1398
P ++ + + +LE K
Sbjct: 421 LRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFYI 480
Query: 1399 XXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYS 1578
+VK+Q FYW HY Q EWL F A F+ LF EM +KMY
Sbjct: 481 RRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYG 540
Query: 1579 LGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXX 1758
LG Y S FN FDC V+I SI E + G+SVLR+ RLLRIFKVTKYW
Sbjct: 541 LGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASL 600
Query: 1759 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQAL 1938
GMQ+FGG+FNF+ + P NFDTF A+
Sbjct: 601 RNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFD--EGTPPTNFDTFPAAI 658
Query: 1939 LTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNL 2118
+TVFQILTGEDWN VMY GI+S GGV G++ IY+IVL + GNY LLNVFLAIAVDNL
Sbjct: 659 MTVFQILTGEDWNEVMYDGIKSQGGVQG-GMVFSIYFIVLTLFGNYTLLNVFLAIAVDNL 717
Query: 2119 ADADSLT 2139
A+A LT
Sbjct: 718 ANAQELT 724
Score = 168 bits (426), Expect = 1e-39
Identities = 159/660 (24%), Positives = 278/660 (42%), Gaps = 29/660 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+R+LC I+ + FE IL +I + IALA P Q + +N +L +YVF VF
Sbjct: 1231 NPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDP--VQPNAPRNNVLRYFDYVFTGVF 1288
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD---VKALRA 573
T E V+K++ +G + H AY R+ WNILDFI+V LV+ + S +G D +K+LR
Sbjct: 1289 TFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNS-KGKDINTIKSLRV 1347
Query: 574 FRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTC 753
RVLRPL+ + +P L+ V + ++ ++ + +I ++ + + I+A++ ++LF GK C
Sbjct: 1348 LRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFH-C 1406
Query: 754 IDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDN 933
D + + +KD E + K + + W+ ++DN
Sbjct: 1407 TDES--KEFEKDCRGKYLLYEKNEVKARDRE--------WKKYE-----------FHYDN 1445
Query: 934 FGLAMLTVFQCVSLEGWTDVMYWVNDAV---------GREWPWIYFVTLVILGSFFVLNL 1086
A+LT+F + EGW V+ DA R I++V ++ FF +N+
Sbjct: 1446 VLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNI 1505
Query: 1087 VLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEP 1266
+ ++ F ++ + K E+ LE++ + +D+ A+ +
Sbjct: 1506 FVALIIITFQEQGD---------KMMEEYSLEKNERACIDFAISAKPL------------ 1544
Query: 1267 VAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXX 1446
+ + + V S F +
Sbjct: 1545 -----------------------------TRHMPQNKQSFQYRMWQFVVSPPFEYTIMAM 1575
Query: 1447 XXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDC 1626
+ YG S ++ + N+ F LFS+E +LK+ + G Y +N FD
Sbjct: 1576 IALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDF 1635
Query: 1627 FVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXX 1806
V+ SI + ++ F + +S LR R R+ K+ +
Sbjct: 1636 VTVLGSITDILVTEFG-NNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPY 1694
Query: 1807 XXXXXXXXXXXXXXXGMQVFGG--------KFNFNPQQPKPRANFDTFVQALLTVFQILT 1962
GMQVFG + + Q NF TF QAL+ +F+ T
Sbjct: 1695 VCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSAT 1754
Query: 1963 GEDWNTVMYHGI-----ESFGGVGT--LGVIVCIYYIV--LFICGNYILLNVFLAIAVDN 2115
GE W+ +M + + G+ T G +Y V +F+C ++++LN+F+A+ +DN
Sbjct: 1755 GEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1813
Score = 120 bits (300), Expect = 5e-25
Identities = 73/274 (26%), Positives = 139/274 (50%), Gaps = 4/274 (1%)
Frame = +1
Query: 3313 RLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEA 3492
R+++ + V ++AF + + ++ +NT+ +A HY DFL IF G+F E
Sbjct: 475 RMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEM 534
Query: 3493 VLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVK 3672
+K+ L + Y +N FD V++GS ++ + + PG + I+ R R++R+ K
Sbjct: 535 FIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTS--FGISVLRALRLLRIFK 592
Query: 3673 LLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNN 3849
+ +R L+ + + S +++ + L+ L ++A++GMQ F G+ D+ T
Sbjct: 593 VTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTP---PT 649
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FPAAI+ +F+ TGE W ++M + ++ +GG+ G
Sbjct: 650 NFDTFPAAIMTVFQILTGEDWNEVMY-----DGIK--------SQGGVQ----GGMVFSI 692
Query: 4030 YFISFFMLCSFLVINLFVAVIMDNF---DYLTRD 4122
YFI + ++ ++N+F+A+ +DN LT+D
Sbjct: 693 YFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 726
Score = 95.5 bits (236), Expect = 1e-17
Identities = 73/296 (24%), Positives = 130/296 (43%), Gaps = 13/296 (4%)
Frame = +1
Query: 265 PFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFM 444
PFE+ I+ MI N I L + + Y+N L VF +F++ECVLK++A G +
Sbjct: 1567 PFEYTIMAMIALNTIVLMM--KFYGASVAYENAL-RVFNIVFTSLFSLECVLKVMAFGIL 1623
Query: 445 FHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQ 624
Y R+AWNI DF+ V+ + ++++ ++ LR FR R ++L+ +++
Sbjct: 1624 ----NYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIR 1679
Query: 625 VVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCG 804
++L +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1680 ILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF------------------------- 1714
Query: 805 TDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGW 984
N+G+ E + NF F A++ +F+ + E W
Sbjct: 1715 ----------------GNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAW 1758
Query: 985 TDVMYWV--------NDAV-----GREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
++M N + G E+ + YFV+ + L SF +LNL + V+ F
Sbjct: 1759 HNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1814
Score = 86.7 bits (213), Expect = 6e-15
Identities = 70/263 (26%), Positives = 117/263 (43%), Gaps = 13/263 (4%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLF+ S N R + + F +L I+ + +LA E L + M L+
Sbjct: 77 SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSL-----TSFVLRTDAM 2667
+ +F +F E +K+I G FHKGS+ RN +N++D +VV + T F LRT
Sbjct: 137 EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRT--- 193
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
++ L+ V++ ++ A+ + I L+ F +FAIIG++ +
Sbjct: 194 -----LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFY 248
Query: 2848 KGTFFL------CNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAM 3009
G F +D+ + A C E + TK +N FDN+ A+
Sbjct: 249 MGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAV 308
Query: 3010 ISLFVVSTFEGWPQLLYVAIDSN 3078
+++F T EGW LLY + D++
Sbjct: 309 LTVFQCITMEGWTDLLYNSNDAS 331
Score = 80.9 bits (198), Expect = 3e-13
Identities = 75/293 (25%), Positives = 123/293 (41%), Gaps = 43/293 (14%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY+I I+ N + LA + H P + LD F G+F FEA +KI+AL
Sbjct: 100 FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WNV D +VV+ G L GT + R RV+R +KL+S
Sbjct: 160 HKGSYLRNGWNVMDFVVVL-------TGILATVGTE-FDLRTLRAVRVLRPLKLVSGIPS 211
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQF----FGKVALDDSTSIHR------ 3843
++ +L + MK+ L + LL+ I+A+IG++F F ++ T +
Sbjct: 212 LQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAP 271
Query: 3844 -----------------------NN---NFHSFPAAILVLFRSATGEAWQDIMLSCSDRE 3945
NN F + A+L +F+ T E W D++ + +D
Sbjct: 272 CGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDAS 331
Query: 3946 DVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
GN + + YFI ++ SF ++NL + V+ F
Sbjct: 332 ---------------------GNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 363
Score = 75.9 bits (185), Expect = 1e-11
Identities = 72/322 (22%), Positives = 140/322 (43%), Gaps = 16/322 (4%)
Frame = +1
Query: 250 IVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIV 429
+V+ + F + +L ++ N + +AI ++ + L E++F+ +F E +K+
Sbjct: 483 MVKTQAFYWTVLSLVALNTLCVAIVH---YNQPEWLSDFLYYAEFIFLGLFMSEMFIKMY 539
Query: 430 AMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKALRAFRVLRPLRLV 603
+G Y +++N D V+IG + ++ + G F + LRA R+LR ++
Sbjct: 540 GLG----TRPYFHSSFNCFD-CGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVT 594
Query: 604 SGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ 783
SL+ ++ ++L +M ++ + L+ I+++A++G++LF GQ
Sbjct: 595 KYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLF------------GGQFNF 642
Query: 784 KDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQ 963
+ TP TNFD F A++TVFQ
Sbjct: 643 DEGTPP---------------------------------------TNFDTFPAAIMTVFQ 663
Query: 964 CVSLEGWTDVMY-WVNDAVGREWPW---IYFVTLVILGSFFVLNLVLGV----------L 1101
++ E W +VMY + G + IYF+ L + G++ +LN+ L + L
Sbjct: 664 ILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQEL 723
Query: 1102 SGEFSKEREKARARGLFQKFRE 1167
+ + +E E A + QK +E
Sbjct: 724 TKDEQEEEEAANQKLALQKAKE 745
Score = 46.2 bits (108), Expect = 0.009
Identities = 50/264 (18%), Positives = 103/264 (38%), Gaps = 3/264 (1%)
Frame = +1
Query: 2293 AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN 2472
A +++K +S F R + +V F VL + +++ +A Q
Sbjct: 454 ARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPE 513
Query: 2473 STRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL 2652
+ L Y ++ F +F E+ +K+ G + ++FN D V+ S+ +
Sbjct: 514 WLSDF-LYYAEFIFLGLFMSEMFIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIW 568
Query: 2653 RTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
K L+++V ++ ++K+I +++ + F+ +F
Sbjct: 569 AVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
Query: 2824 AIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGD 3003
A++G+QLF G F ++++G P NFD
Sbjct: 629 ALLGMQLFGGQF-------------------NFDEGTPPT-------------NFDTFPA 656
Query: 3004 AMISLFVVSTFEGWPQLLYVAIDS 3075
A++++F + T E W +++Y I S
Sbjct: 657 AIMTVFQILTGEDWNEVMYDGIKS 680
>gi|18958263|dbj|BAB85612.1| CaV2.1 [Mus musculus]
Length = 2365
Score = 677 bits (1748), Expect = 0.0
Identities = 356/779 (45%), Positives = 496/779 (62%), Gaps = 17/779 (2%)
Frame = +1
Query: 2290 PAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQA 2469
P KP+P SS+FILS TN R C+ ++N YF +L I +SS LAAEDP+Q
Sbjct: 1161 PGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQP 1220
Query: 2470 NSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFV 2649
N+ RN +L YFDY FT VFT E+ +K+I GLV H+G++ R+ +N+LD +VV+ +L +F
Sbjct: 1221 NAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFA 1280
Query: 2650 LRTDA----MSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQF 2817
++ ++ I R LK V CV+ ++K + NI++V + F
Sbjct: 1281 FTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMF 1340
Query: 2818 MFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNV 2997
+FA++ VQLFKG FF C D SK E +CRG+Y+ YE + ++ R W +F++DNV
Sbjct: 1341 IFAVVAVQLFKGKFFHCTDESKEFERDCRGKYLLYEKNEVK---ARDREWKKYEFHYDNV 1397
Query: 2998 GDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXX 3177
A+++LF VST EGWPQ+L ++D+ E++GP R +++
Sbjct: 1398 LWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIF 1457
Query: 3178 XGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSR 3351
+I+TFQ +G++ E L+KN+R CI+FA+ AKP R++P+N+ QYR+W FV S
Sbjct: 1458 VALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSP 1517
Query: 3352 AFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYI 3531
FEY I +I +NT+ L K Y +S +E+ L VFN++FT +F+ E VLK++A NY
Sbjct: 1518 PFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYF 1577
Query: 3532 SDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLW 3711
D WN+FD + V+GS DI + G N I+++F RLFR RL+KLL +G IR LLW
Sbjct: 1578 RDAWNIFDFVTVLGSITDILVTEF---GNNFINLSFLRLFRAARLIKLLRQGYTIRILLW 1634
Query: 3712 TFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALD--------DSTSIHRNNNFHSFP 3867
TF++SF+ALPYV LLI +LFFIYA+IGMQ FG + +D D I +NNF +F
Sbjct: 1635 TFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDGEDEDSDEDEFQITEHNNFRTFF 1694
Query: 3868 AAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFF 4047
A+++LFRSATGEAW +IMLSC + CD S G+ + CGN FAY YF+SF
Sbjct: 1695 QALMLLFRSATGEAWHNIMLSCLSGKP--CDKNS------GILTADCGNEFAYFYFVSFI 1746
Query: 4048 MLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTL 4227
LCSFL++NLFVAVIMDNF+YLTRD SILGPHHL+E+VR+W+EYDP A GRI + D+ +L
Sbjct: 1747 FLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAACGRIHYKDMYSL 1806
Query: 4228 LRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKI-YTEGNID 4404
LR ISPPLG GK CPHR+ACKRL+ M++P+ D TV FN+TL AL+RT L I +G D
Sbjct: 1807 LRVISPPLGLGKKCPHRVACKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGAD 1866
Query: 4405 --EANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRK 4575
+ + +LR + IW + LD +V P K D+TVGK YA +I +Y+R+ K +K
Sbjct: 1867 KQQMDAELRKEMMAIWPNLSQKTLDLLVTP-HKSTDLTVGKIYAAMMIMEYYRQSKAKK 1924
Score = 536 bits (1380), Expect = e-150
Identities = 296/667 (44%), Positives = 383/667 (57%), Gaps = 27/667 (4%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N +RK I EW PFE++IL I ANCI LA+ Q P D + L+ E FI +
Sbjct: 86 DNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGI 145
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KIVA+GF FH +YLRN WN++DF++V+ G+++T+ ++ FD++ LRA R
Sbjct: 146 FCFEAGIKIVALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE-----FDLRTLRAVR 200
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQVVL +I++AMIPLL I LL+ F ILI+AIIGLE + GK H+TC +
Sbjct: 201 VLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFE 260
Query: 760 PATGQLAQKDPTPCGTD----TEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNF 927
T + + P PCGT+ T + KCQP W GPNNGIT F
Sbjct: 261 EGTDDIQGESPAPCGTEEPARTCPNGTKCQPY-----------------WEGPNNGITQF 303
Query: 928 DNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSG 1107
DN A+LTVFQC+++EGWTD++Y NDA G W W+YF+ L+I+GSFF+LNLVLGVLSG
Sbjct: 304 DNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSG 363
Query: 1108 EFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVAQTXXX 1287
EF+KERE+ R F K R +QQ+E +L GY++WI++AE++ + EDE + E
Sbjct: 364 EFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEV-ILAEDETDVEQRHPFDGA 422
Query: 1288 XXXXXXXXXXXXXXXP-----------------SKWAARMKRLE------KLNXXXXXXX 1398
P ++ + + +LE K
Sbjct: 423 LRRATLKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFYI 482
Query: 1399 XXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYS 1578
+VK+Q FYW HY Q EWL F A F+ LF EM +KMY
Sbjct: 483 RRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYG 542
Query: 1579 LGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXX 1758
LG Y S FN FDC V+I SI E + G+SVLR+ RLLRIFKVTKYW
Sbjct: 543 LGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASL 602
Query: 1759 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQAL 1938
GMQ+FGG+FNF+ + P NFDTF A+
Sbjct: 603 RNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFD--EGTPPTNFDTFPAAI 660
Query: 1939 LTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNL 2118
+TVFQILTGEDWN VMY GI+S GGV G++ IY+IVL + GNY LLNVFLAIAVDNL
Sbjct: 661 MTVFQILTGEDWNEVMYDGIKSQGGVQG-GMVFSIYFIVLTLFGNYTLLNVFLAIAVDNL 719
Query: 2119 ADADSLT 2139
A+A LT
Sbjct: 720 ANAQELT 726
Score = 168 bits (425), Expect = 2e-39
Identities = 157/660 (23%), Positives = 274/660 (40%), Gaps = 29/660 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+R+LC I+ + FE IL +I + IALA P Q + +N +L +YVF VF
Sbjct: 1182 NPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDP--VQPNAPRNNVLRYFDYVFTGVF 1239
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD---VKALRA 573
T E V+K++ +G + H AY R+ WNILDFI+V LV+ + S +G D +K+LR
Sbjct: 1240 TFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNS-KGKDINTIKSLRV 1298
Query: 574 FRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTC 753
RVLRPL+ + +P L+ V + ++ ++ + +I ++ + + I+A++ ++LF GK C
Sbjct: 1299 LRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFH-C 1357
Query: 754 IDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDN 933
D + D G + + + W+ ++DN
Sbjct: 1358 TD---------ESKEFERDCRGK-YLLYEKNEVKARDREWKKYE-----------FHYDN 1396
Query: 934 FGLAMLTVFQCVSLEGWTDVMYWVNDAV---------GREWPWIYFVTLVILGSFFVLNL 1086
A+LT+F + EGW V+ DA R I++V ++ FF +N+
Sbjct: 1397 VLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNI 1456
Query: 1087 VLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEP 1266
+ ++ F ++ + K E+ LE++ + +D+ A+ +
Sbjct: 1457 FVALIIITFQEQGD---------KMMEEYSLEKNERACIDFAISAKPL------------ 1495
Query: 1267 VAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXX 1446
+ + + V S F +
Sbjct: 1496 -----------------------------TRHMPQNKQSFQYRMWQFVVSPPFEYTIMAM 1526
Query: 1447 XXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDC 1626
+ YG S ++ + N+ F LFS+E +LK+ + G Y +N FD
Sbjct: 1527 IALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDF 1586
Query: 1627 FVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXX 1806
V+ SI + ++ F + +S LR R R+ K+ +
Sbjct: 1587 VTVLGSITDILVTEFG-NNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPY 1645
Query: 1807 XXXXXXXXXXXXXXXGMQVFGG--------KFNFNPQQPKPRANFDTFVQALLTVFQILT 1962
GMQVFG + + Q NF TF QAL+ +F+ T
Sbjct: 1646 VCLLIAMLFFIYAIIGMQVFGNIGIDGEDEDSDEDEFQITEHNNFRTFFQALMLLFRSAT 1705
Query: 1963 GEDWNTVMYHGI-----ESFGGVGT--LGVIVCIYYIV--LFICGNYILLNVFLAIAVDN 2115
GE W+ +M + + G+ T G +Y V +F+C ++++LN+F+A+ +DN
Sbjct: 1706 GEAWHNIMLSCLSGKPCDKNSGILTADCGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1764
Score = 120 bits (300), Expect = 5e-25
Identities = 73/274 (26%), Positives = 139/274 (50%), Gaps = 4/274 (1%)
Frame = +1
Query: 3313 RLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEA 3492
R+++ + V ++AF + + ++ +NT+ +A HY DFL IF G+F E
Sbjct: 477 RMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEM 536
Query: 3493 VLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVK 3672
+K+ L + Y +N FD V++GS ++ + + PG + I+ R R++R+ K
Sbjct: 537 FIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTS--FGISVLRALRLLRIFK 594
Query: 3673 LLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNN 3849
+ +R L+ + + S +++ + L+ L ++A++GMQ F G+ D+ T
Sbjct: 595 VTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTP---PT 651
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FPAAI+ +F+ TGE W ++M + ++ +GG+ G
Sbjct: 652 NFDTFPAAIMTVFQILTGEDWNEVMY-----DGIK--------SQGGVQ----GGMVFSI 694
Query: 4030 YFISFFMLCSFLVINLFVAVIMDNF---DYLTRD 4122
YFI + ++ ++N+F+A+ +DN LT+D
Sbjct: 695 YFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 728
Score = 95.9 bits (237), Expect = 1e-17
Identities = 73/296 (24%), Positives = 130/296 (43%), Gaps = 13/296 (4%)
Frame = +1
Query: 265 PFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFM 444
PFE+ I+ MI N I L + + Y+N L VF +F++ECVLK++A G +
Sbjct: 1518 PFEYTIMAMIALNTIVLMM--KFYGASVAYENAL-RVFNIVFTSLFSLECVLKVMAFGIL 1574
Query: 445 FHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQ 624
Y R+AWNI DF+ V+ + ++++ ++ LR FR R ++L+ +++
Sbjct: 1575 ----NYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIR 1630
Query: 625 VVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCG 804
++L +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1631 ILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF------------------------- 1665
Query: 805 TDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGW 984
N+G+ E + NF F A++ +F+ + E W
Sbjct: 1666 ----------------GNIGIDGEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAW 1709
Query: 985 TDVMYWV--------NDAV-----GREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
++M N + G E+ + YFV+ + L SF +LNL + V+ F
Sbjct: 1710 HNIMLSCLSGKPCDKNSGILTADCGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1765
Score = 86.3 bits (212), Expect = 8e-15
Identities = 69/263 (26%), Positives = 117/263 (44%), Gaps = 13/263 (4%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLF+ S N R + + F +L I+ + +LA E L + M L+
Sbjct: 79 SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 138
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSL-----TSFVLRTDAM 2667
+ +F +F E +K++ G FHKGS+ RN +N++D +VV + T F LRT
Sbjct: 139 EPYFIGIFCFEAGIKIVALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRT--- 195
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
++ L+ V++ ++ A+ + I L+ F +FAIIG++ +
Sbjct: 196 -----LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFY 250
Query: 2848 KGTFFL------CNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAM 3009
G F +D+ + A C E + TK +N FDN+ A+
Sbjct: 251 MGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAV 310
Query: 3010 ISLFVVSTFEGWPQLLYVAIDSN 3078
+++F T EGW LLY + D++
Sbjct: 311 LTVFQCITMEGWTDLLYNSNDAS 333
Score = 81.3 bits (199), Expect = 3e-13
Identities = 76/293 (25%), Positives = 123/293 (41%), Gaps = 43/293 (14%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY+I I+ N + LA + H P + LD F G+F FEA +KIVAL
Sbjct: 102 FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIVALGFAF 161
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WNV D +VV+ G L GT + R RV+R +KL+S
Sbjct: 162 HKGSYLRNGWNVMDFVVVL-------TGILATVGTE-FDLRTLRAVRVLRPLKLVSGIPS 213
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQF----FGKVALDDSTSIHR------ 3843
++ +L + MK+ L + LL+ I+A+IG++F F ++ T +
Sbjct: 214 LQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAP 273
Query: 3844 -----------------------NN---NFHSFPAAILVLFRSATGEAWQDIMLSCSDRE 3945
NN F + A+L +F+ T E W D++ + +D
Sbjct: 274 CGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDAS 333
Query: 3946 DVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
GN + + YFI ++ SF ++NL + V+ F
Sbjct: 334 ---------------------GNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 365
Score = 75.9 bits (185), Expect = 1e-11
Identities = 72/322 (22%), Positives = 140/322 (43%), Gaps = 16/322 (4%)
Frame = +1
Query: 250 IVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIV 429
+V+ + F + +L ++ N + +AI ++ + L E++F+ +F E +K+
Sbjct: 485 MVKTQAFYWTVLSLVALNTLCVAIVH---YNQPEWLSDFLYYAEFIFLGLFMSEMFIKMY 541
Query: 430 AMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKALRAFRVLRPLRLV 603
+G Y +++N D V+IG + ++ + G F + LRA R+LR ++
Sbjct: 542 GLG----TRPYFHSSFNCFD-CGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVT 596
Query: 604 SGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ 783
SL+ ++ ++L +M ++ + L+ I+++A++G++LF GQ
Sbjct: 597 KYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLF------------GGQFNF 644
Query: 784 KDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQ 963
+ TP TNFD F A++TVFQ
Sbjct: 645 DEGTPP---------------------------------------TNFDTFPAAIMTVFQ 665
Query: 964 CVSLEGWTDVMY-WVNDAVGREWPW---IYFVTLVILGSFFVLNLVLGV----------L 1101
++ E W +VMY + G + IYF+ L + G++ +LN+ L + L
Sbjct: 666 ILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQEL 725
Query: 1102 SGEFSKEREKARARGLFQKFRE 1167
+ + +E E A + QK +E
Sbjct: 726 TKDEQEEEEAANQKLALQKAKE 747
Score = 46.2 bits (108), Expect = 0.009
Identities = 50/264 (18%), Positives = 103/264 (38%), Gaps = 3/264 (1%)
Frame = +1
Query: 2293 AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN 2472
A +++K +S F R + +V F VL + +++ +A Q
Sbjct: 456 ARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPE 515
Query: 2473 STRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL 2652
+ L Y ++ F +F E+ +K+ G + ++FN D V+ S+ +
Sbjct: 516 WLSDF-LYYAEFIFLGLFMSEMFIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIW 570
Query: 2653 RTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
K L+++V ++ ++K+I +++ + F+ +F
Sbjct: 571 AVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 630
Query: 2824 AIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGD 3003
A++G+QLF G F ++++G P NFD
Sbjct: 631 ALLGMQLFGGQF-------------------NFDEGTPPT-------------NFDTFPA 658
Query: 3004 AMISLFVVSTFEGWPQLLYVAIDS 3075
A++++F + T E W +++Y I S
Sbjct: 659 AIMTVFQILTGEDWNEVMYDGIKS 682
>gi|18958261|dbj|BAB85611.1| CaV2.1 [Mus musculus]
Length = 2327
Score = 677 bits (1748), Expect = 0.0
Identities = 356/779 (45%), Positives = 496/779 (62%), Gaps = 17/779 (2%)
Frame = +1
Query: 2290 PAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQA 2469
P KP+P SS+FILS TN R C+ ++N YF +L I +SS LAAEDP+Q
Sbjct: 1161 PGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQP 1220
Query: 2470 NSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFV 2649
N+ RN +L YFDY FT VFT E+ +K+I GLV H+G++ R+ +N+LD +VV+ +L +F
Sbjct: 1221 NAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFA 1280
Query: 2650 LRTDA----MSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQF 2817
++ ++ I R LK V CV+ ++K + NI++V + F
Sbjct: 1281 FTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMF 1340
Query: 2818 MFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNV 2997
+FA++ VQLFKG FF C D SK E +CRG+Y+ YE + ++ R W +F++DNV
Sbjct: 1341 IFAVVAVQLFKGKFFHCTDESKEFERDCRGKYLLYEKNEVK---ARDREWKKYEFHYDNV 1397
Query: 2998 GDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXX 3177
A+++LF VST EGWPQ+L ++D+ E++GP R +++
Sbjct: 1398 LWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIF 1457
Query: 3178 XGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSR 3351
+I+TFQ +G++ E L+KN+R CI+FA+ AKP R++P+N+ QYR+W FV S
Sbjct: 1458 VALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSP 1517
Query: 3352 AFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYI 3531
FEY I +I +NT+ L K Y +S +E+ L VFN++FT +F+ E VLK++A NY
Sbjct: 1518 PFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYF 1577
Query: 3532 SDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLW 3711
D WN+FD + V+GS DI + G N I+++F RLFR RL+KLL +G IR LLW
Sbjct: 1578 RDAWNIFDFVTVLGSITDILVTEF---GNNFINLSFLRLFRAARLIKLLRQGYTIRILLW 1634
Query: 3712 TFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALD--------DSTSIHRNNNFHSFP 3867
TF++SF+ALPYV LLI +LFFIYA+IGMQ FG + +D D I +NNF +F
Sbjct: 1635 TFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDGEDEDSDEDEFQITEHNNFRTFF 1694
Query: 3868 AAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFF 4047
A+++LFRSATGEAW +IMLSC + CD S G+ + CGN FAY YF+SF
Sbjct: 1695 QALMLLFRSATGEAWHNIMLSCLSGKP--CDKNS------GILTADCGNEFAYFYFVSFI 1746
Query: 4048 MLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTL 4227
LCSFL++NLFVAVIMDNF+YLTRD SILGPHHL+E+VR+W+EYDP A GRI + D+ +L
Sbjct: 1747 FLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAACGRIHYKDMYSL 1806
Query: 4228 LRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKI-YTEGNID 4404
LR ISPPLG GK CPHR+ACKRL+ M++P+ D TV FN+TL AL+RT L I +G D
Sbjct: 1807 LRVISPPLGLGKKCPHRVACKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGAD 1866
Query: 4405 --EANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRK 4575
+ + +LR + IW + LD +V P K D+TVGK YA +I +Y+R+ K +K
Sbjct: 1867 KQQMDAELRKEMMAIWPNLSQKTLDLLVTP-HKSTDLTVGKIYAAMMIMEYYRQSKAKK 1924
Score = 536 bits (1380), Expect = e-150
Identities = 296/667 (44%), Positives = 383/667 (57%), Gaps = 27/667 (4%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N +RK I EW PFE++IL I ANCI LA+ Q P D + L+ E FI +
Sbjct: 86 DNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGI 145
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KIVA+GF FH +YLRN WN++DF++V+ G+++T+ ++ FD++ LRA R
Sbjct: 146 FCFEAGIKIVALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE-----FDLRTLRAVR 200
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQVVL +I++AMIPLL I LL+ F ILI+AIIGLE + GK H+TC +
Sbjct: 201 VLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFE 260
Query: 760 PATGQLAQKDPTPCGTD----TEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNF 927
T + + P PCGT+ T + KCQP W GPNNGIT F
Sbjct: 261 EGTDDIQGESPAPCGTEEPARTCPNGTKCQPY-----------------WEGPNNGITQF 303
Query: 928 DNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSG 1107
DN A+LTVFQC+++EGWTD++Y NDA G W W+YF+ L+I+GSFF+LNLVLGVLSG
Sbjct: 304 DNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSG 363
Query: 1108 EFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVAQTXXX 1287
EF+KERE+ R F K R +QQ+E +L GY++WI++AE++ + EDE + E
Sbjct: 364 EFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEV-ILAEDETDVEQRHPFDGA 422
Query: 1288 XXXXXXXXXXXXXXXP-----------------SKWAARMKRLE------KLNXXXXXXX 1398
P ++ + + +LE K
Sbjct: 423 LRRATLKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFYI 482
Query: 1399 XXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYS 1578
+VK+Q FYW HY Q EWL F A F+ LF EM +KMY
Sbjct: 483 RRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYG 542
Query: 1579 LGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXX 1758
LG Y S FN FDC V+I SI E + G+SVLR+ RLLRIFKVTKYW
Sbjct: 543 LGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASL 602
Query: 1759 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQAL 1938
GMQ+FGG+FNF+ + P NFDTF A+
Sbjct: 603 RNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFD--EGTPPTNFDTFPAAI 660
Query: 1939 LTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNL 2118
+TVFQILTGEDWN VMY GI+S GGV G++ IY+IVL + GNY LLNVFLAIAVDNL
Sbjct: 661 MTVFQILTGEDWNEVMYDGIKSQGGVQG-GMVFSIYFIVLTLFGNYTLLNVFLAIAVDNL 719
Query: 2119 ADADSLT 2139
A+A LT
Sbjct: 720 ANAQELT 726
Score = 168 bits (425), Expect = 2e-39
Identities = 157/660 (23%), Positives = 274/660 (40%), Gaps = 29/660 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+R+LC I+ + FE IL +I + IALA P Q + +N +L +YVF VF
Sbjct: 1182 NPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDP--VQPNAPRNNVLRYFDYVFTGVF 1239
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD---VKALRA 573
T E V+K++ +G + H AY R+ WNILDFI+V LV+ + S +G D +K+LR
Sbjct: 1240 TFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNS-KGKDINTIKSLRV 1298
Query: 574 FRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTC 753
RVLRPL+ + +P L+ V + ++ ++ + +I ++ + + I+A++ ++LF GK C
Sbjct: 1299 LRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFH-C 1357
Query: 754 IDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDN 933
D + D G + + + W+ ++DN
Sbjct: 1358 TD---------ESKEFERDCRGK-YLLYEKNEVKARDREWKKYE-----------FHYDN 1396
Query: 934 FGLAMLTVFQCVSLEGWTDVMYWVNDAV---------GREWPWIYFVTLVILGSFFVLNL 1086
A+LT+F + EGW V+ DA R I++V ++ FF +N+
Sbjct: 1397 VLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNI 1456
Query: 1087 VLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEP 1266
+ ++ F ++ + K E+ LE++ + +D+ A+ +
Sbjct: 1457 FVALIIITFQEQGD---------KMMEEYSLEKNERACIDFAISAKPL------------ 1495
Query: 1267 VAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXX 1446
+ + + V S F +
Sbjct: 1496 -----------------------------TRHMPQNKQSFQYRMWQFVVSPPFEYTIMAM 1526
Query: 1447 XXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDC 1626
+ YG S ++ + N+ F LFS+E +LK+ + G Y +N FD
Sbjct: 1527 IALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDF 1586
Query: 1627 FVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXX 1806
V+ SI + ++ F + +S LR R R+ K+ +
Sbjct: 1587 VTVLGSITDILVTEFG-NNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPY 1645
Query: 1807 XXXXXXXXXXXXXXXGMQVFGG--------KFNFNPQQPKPRANFDTFVQALLTVFQILT 1962
GMQVFG + + Q NF TF QAL+ +F+ T
Sbjct: 1646 VCLLIAMLFFIYAIIGMQVFGNIGIDGEDEDSDEDEFQITEHNNFRTFFQALMLLFRSAT 1705
Query: 1963 GEDWNTVMYHGI-----ESFGGVGT--LGVIVCIYYIV--LFICGNYILLNVFLAIAVDN 2115
GE W+ +M + + G+ T G +Y V +F+C ++++LN+F+A+ +DN
Sbjct: 1706 GEAWHNIMLSCLSGKPCDKNSGILTADCGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1764
Score = 120 bits (300), Expect = 5e-25
Identities = 73/274 (26%), Positives = 139/274 (50%), Gaps = 4/274 (1%)
Frame = +1
Query: 3313 RLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEA 3492
R+++ + V ++AF + + ++ +NT+ +A HY DFL IF G+F E
Sbjct: 477 RMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEM 536
Query: 3493 VLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVK 3672
+K+ L + Y +N FD V++GS ++ + + PG + I+ R R++R+ K
Sbjct: 537 FIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTS--FGISVLRALRLLRIFK 594
Query: 3673 LLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNN 3849
+ +R L+ + + S +++ + L+ L ++A++GMQ F G+ D+ T
Sbjct: 595 VTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTP---PT 651
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FPAAI+ +F+ TGE W ++M + ++ +GG+ G
Sbjct: 652 NFDTFPAAIMTVFQILTGEDWNEVMY-----DGIK--------SQGGVQ----GGMVFSI 694
Query: 4030 YFISFFMLCSFLVINLFVAVIMDNF---DYLTRD 4122
YFI + ++ ++N+F+A+ +DN LT+D
Sbjct: 695 YFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 728
Score = 95.9 bits (237), Expect = 1e-17
Identities = 73/296 (24%), Positives = 130/296 (43%), Gaps = 13/296 (4%)
Frame = +1
Query: 265 PFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFM 444
PFE+ I+ MI N I L + + Y+N L VF +F++ECVLK++A G +
Sbjct: 1518 PFEYTIMAMIALNTIVLMM--KFYGASVAYENAL-RVFNIVFTSLFSLECVLKVMAFGIL 1574
Query: 445 FHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQ 624
Y R+AWNI DF+ V+ + ++++ ++ LR FR R ++L+ +++
Sbjct: 1575 ----NYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIR 1630
Query: 625 VVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCG 804
++L +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1631 ILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF------------------------- 1665
Query: 805 TDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGW 984
N+G+ E + NF F A++ +F+ + E W
Sbjct: 1666 ----------------GNIGIDGEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAW 1709
Query: 985 TDVMYWV--------NDAV-----GREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
++M N + G E+ + YFV+ + L SF +LNL + V+ F
Sbjct: 1710 HNIMLSCLSGKPCDKNSGILTADCGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1765
Score = 86.3 bits (212), Expect = 8e-15
Identities = 69/263 (26%), Positives = 117/263 (44%), Gaps = 13/263 (4%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLF+ S N R + + F +L I+ + +LA E L + M L+
Sbjct: 79 SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 138
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSL-----TSFVLRTDAM 2667
+ +F +F E +K++ G FHKGS+ RN +N++D +VV + T F LRT
Sbjct: 139 EPYFIGIFCFEAGIKIVALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRT--- 195
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
++ L+ V++ ++ A+ + I L+ F +FAIIG++ +
Sbjct: 196 -----LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFY 250
Query: 2848 KGTFFL------CNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAM 3009
G F +D+ + A C E + TK +N FDN+ A+
Sbjct: 251 MGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAV 310
Query: 3010 ISLFVVSTFEGWPQLLYVAIDSN 3078
+++F T EGW LLY + D++
Sbjct: 311 LTVFQCITMEGWTDLLYNSNDAS 333
Score = 81.3 bits (199), Expect = 3e-13
Identities = 76/293 (25%), Positives = 123/293 (41%), Gaps = 43/293 (14%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY+I I+ N + LA + H P + LD F G+F FEA +KIVAL
Sbjct: 102 FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIVALGFAF 161
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WNV D +VV+ G L GT + R RV+R +KL+S
Sbjct: 162 HKGSYLRNGWNVMDFVVVL-------TGILATVGTE-FDLRTLRAVRVLRPLKLVSGIPS 213
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQF----FGKVALDDSTSIHR------ 3843
++ +L + MK+ L + LL+ I+A+IG++F F ++ T +
Sbjct: 214 LQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAP 273
Query: 3844 -----------------------NN---NFHSFPAAILVLFRSATGEAWQDIMLSCSDRE 3945
NN F + A+L +F+ T E W D++ + +D
Sbjct: 274 CGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDAS 333
Query: 3946 DVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
GN + + YFI ++ SF ++NL + V+ F
Sbjct: 334 ---------------------GNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 365
Score = 75.9 bits (185), Expect = 1e-11
Identities = 72/322 (22%), Positives = 140/322 (43%), Gaps = 16/322 (4%)
Frame = +1
Query: 250 IVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIV 429
+V+ + F + +L ++ N + +AI ++ + L E++F+ +F E +K+
Sbjct: 485 MVKTQAFYWTVLSLVALNTLCVAIVH---YNQPEWLSDFLYYAEFIFLGLFMSEMFIKMY 541
Query: 430 AMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKALRAFRVLRPLRLV 603
+G Y +++N D V+IG + ++ + G F + LRA R+LR ++
Sbjct: 542 GLG----TRPYFHSSFNCFD-CGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVT 596
Query: 604 SGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ 783
SL+ ++ ++L +M ++ + L+ I+++A++G++LF GQ
Sbjct: 597 KYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLF------------GGQFNF 644
Query: 784 KDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQ 963
+ TP TNFD F A++TVFQ
Sbjct: 645 DEGTPP---------------------------------------TNFDTFPAAIMTVFQ 665
Query: 964 CVSLEGWTDVMY-WVNDAVGREWPW---IYFVTLVILGSFFVLNLVLGV----------L 1101
++ E W +VMY + G + IYF+ L + G++ +LN+ L + L
Sbjct: 666 ILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQEL 725
Query: 1102 SGEFSKEREKARARGLFQKFRE 1167
+ + +E E A + QK +E
Sbjct: 726 TKDEQEEEEAANQKLALQKAKE 747
Score = 46.2 bits (108), Expect = 0.009
Identities = 50/264 (18%), Positives = 103/264 (38%), Gaps = 3/264 (1%)
Frame = +1
Query: 2293 AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN 2472
A +++K +S F R + +V F VL + +++ +A Q
Sbjct: 456 ARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPE 515
Query: 2473 STRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL 2652
+ L Y ++ F +F E+ +K+ G + ++FN D V+ S+ +
Sbjct: 516 WLSDF-LYYAEFIFLGLFMSEMFIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIW 570
Query: 2653 RTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
K L+++V ++ ++K+I +++ + F+ +F
Sbjct: 571 AVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 630
Query: 2824 AIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGD 3003
A++G+QLF G F ++++G P NFD
Sbjct: 631 ALLGMQLFGGQF-------------------NFDEGTPPT-------------NFDTFPA 658
Query: 3004 AMISLFVVSTFEGWPQLLYVAIDS 3075
A++++F + T E W +++Y I S
Sbjct: 659 AIMTVFQILTGEDWNEVMYDGIKS 682
>gi|1657333|emb|CAA68172.1| calcium channel alpha1 subunit [Homo
sapiens]
Length = 2262
Score = 676 bits (1745), Expect = 0.0
Identities = 408/1021 (39%), Positives = 569/1021 (54%), Gaps = 62/1021 (6%)
Frame = +1
Query: 2308 KPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNM 2487
KP+P SS+FILS TN R C+ ++N YF +L I +SS LAAEDP+Q N+ RN
Sbjct: 1217 KPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNN 1276
Query: 2488 ILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDA- 2664
+L YFDY FT VFT E+ +K+I GLV H+G++ R+ +N+LD +VV+ +L +F ++
Sbjct: 1277 VLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSK 1336
Query: 2665 ---MSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIG 2835
++ I R LK V CV+ ++K + NI++V + F+FA++
Sbjct: 1337 GKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVA 1396
Query: 2836 VQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMIS 3015
VQLFKG FF C D SK E +CRG+Y+ YE + ++ R W +F++DNV A+++
Sbjct: 1397 VQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVK---ARDREWKKYEFHYDNVLWALLT 1453
Query: 3016 LFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIV 3195
LF VST EGWPQ+L ++D+ E++GP R +++ +I+
Sbjct: 1454 LFTVSTAEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIII 1513
Query: 3196 TFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRAFEYVI 3369
TFQ +G++ E L+KN+R CI+FA+ AKP R++P+N+ QYR+W FV S FEY I
Sbjct: 1514 TFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTI 1573
Query: 3370 FLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNV 3549
+I +NT+ L K Y +S +E+ L VFN+ FT +F+ E VLK +A NY D WN+
Sbjct: 1574 MAMIALNTIVLMMKFYGASVAYENALRVFNIAFTSLFSLECVLKAMAFGILNYFRDAWNI 1633
Query: 3550 FDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSF 3729
FD + V+GS DI + G N I+++F RLFR RL+KLL +G IR LLWTF++SF
Sbjct: 1634 FDFVTVLGSITDILVTEF---GNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSF 1690
Query: 3730 QALPYVALLIVLLFFIYAVIGMQFFGKVALD--------DSTSIHRNNNFHSFPAAILVL 3885
+ALPYV LLI +LFFIYA+IGMQ FG + +D D I +NNF +F A+++L
Sbjct: 1691 KALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLL 1750
Query: 3886 FRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFL 4065
FRSATGEAW +IMLSC + CD S G+ CGN FAY YF+SF LCSFL
Sbjct: 1751 FRSATGEAWHNIMLSCLSGKP--CDKNS------GILTRECGNEFAYFYFVSFIFLCSFL 1802
Query: 4066 VINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
++NLFVAVIMDNF+YLTRD SILGPHHL+E+VR+W+EYDP A GRI + D+ +LLR ISP
Sbjct: 1803 MLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAACGRIHYKDMYSLLRVISP 1862
Query: 4246 PLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKI-YTEGNID--EANE 4416
PLG GK CPHR+ACKRL+ M++P+ D TV FN+TL AL+RT L I +G D + +
Sbjct: 1863 PLGLGKKCPHRVACKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDA 1922
Query: 4417 QLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRK------- 4575
+LR + IW + LD +V P K D+TVGK YA +I +Y+R+ K +K
Sbjct: 1923 ELRKEMMAIWPNLSQKTLDLLVTP-HKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAMREE 1981
Query: 4576 ---------EMEAKGVLPAQTPQAMALQA------GLRTLHEIGPE------LKRAISGN 4692
ME P AL + G HE G + +RA
Sbjct: 1982 QDRTPLMFQRMEPPSPTQEGGPGQNALPSTQLDPGGALMAHESGLKESPSWVTQRAQEMF 2041
Query: 4693 LETDFNFDEPEPQHRRPHSLFN--NLVHRLSGAGSKSPTEHERIEKGSTLLPFQPRSFSP 4866
+T E P P+S N ++ R G S +EH +G PR +
Sbjct: 2042 QKTGTWSPEQGPPTDMPNSQPNSQSVEMREMGRDGYSDSEHYLPMEGQGRAASMPRLPAE 2101
Query: 4867 THSLAGAEGSPVPSQMHRGAPINQSINLPPVNGSARR-----LPALPPYANHIHDETDDG 5031
G S + +P+ +S ++ + ARR L +PP N H +
Sbjct: 2102 NQRRRGRPRGNNLSTISDTSPMKRSASV--LGPKARRLDDYSLERVPPEENQRHHQ---- 2155
Query: 5032 PRYRDTGDRAGYDQSSRMVVANRNLPVD----------PDEEEQWMRSGGPSNRSDRRNP 5181
R RD RA R + L D P +E R G P +R R++
Sbjct: 2156 -RRRDRSHRASERSLGRYTDVDTGLGTDLSMTTQSGDLPSKERDQER-GRPKDRKHRQHH 2213
Query: 5182 H 5184
H
Sbjct: 2214 H 2214
Score = 536 bits (1381), Expect = e-150
Identities = 295/667 (44%), Positives = 383/667 (57%), Gaps = 27/667 (4%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N +RK I EW PFE++IL I ANCI LA+ Q P D + L+ E FI +
Sbjct: 84 DNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGI 143
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KI+A+GF FH +YLRN WN++DF++V+ G+++T+ ++ FD++ LRA R
Sbjct: 144 FCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE-----FDLRTLRAVR 198
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQVVL +I++AMIPLL I LL+ F ILI+AIIGLE + GK H+TC +
Sbjct: 199 VLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFE 258
Query: 760 PATGQLAQKDPTPCGTD----TEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNF 927
T + + P PCGT+ T + KCQP W GPNNGIT F
Sbjct: 259 EGTDDIQGESPAPCGTEEPARTCPNGTKCQPY-----------------WEGPNNGITQF 301
Query: 928 DNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSG 1107
DN A+LTVFQC+++EGWTD++Y NDA G W W+YF+ L+I+GSFF+LNLVLGVLSG
Sbjct: 302 DNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSG 361
Query: 1108 EFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVAQTXXX 1287
EF+KERE+ R F K R +QQ+E +L GY++WI++AE++ + EDE + E
Sbjct: 362 EFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEV-ILAEDETDGEQRHPFDGA 420
Query: 1288 XXXXXXXXXXXXXXXP-----------------SKWAARMKRLE------KLNXXXXXXX 1398
P ++ + + +LE K
Sbjct: 421 LRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFYI 480
Query: 1399 XXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYS 1578
+VK+Q FYW HY Q EWL F A F+ LF EM +KMY
Sbjct: 481 RRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYG 540
Query: 1579 LGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXX 1758
LG Y S FN FDC V+I SI E + G+SVLR+ RLLRIFKVTKYW
Sbjct: 541 LGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASL 600
Query: 1759 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQAL 1938
GMQ+FGG+FNF+ + P NFDTF A+
Sbjct: 601 RNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFD--EGTPPTNFDTFPAAI 658
Query: 1939 LTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNL 2118
+TVFQILTGEDWN VMY GI+S GGV G++ IY+IVL + GNY LLNVFLAIAVDNL
Sbjct: 659 MTVFQILTGEDWNEVMYDGIKSQGGVQG-GMVFSIYFIVLTLFGNYTLLNVFLAIAVDNL 717
Query: 2119 ADADSLT 2139
A+A LT
Sbjct: 718 ANAQELT 724
Score = 168 bits (426), Expect = 1e-39
Identities = 159/660 (24%), Positives = 277/660 (41%), Gaps = 29/660 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+R+LC I+ + FE IL +I + IALA P Q + +N +L +YVF VF
Sbjct: 1232 NPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDP--VQPNAPRNNVLRYFDYVFTGVF 1289
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD---VKALRA 573
T E V+K++ +G + H AY R+ WNILDFI+V LV+ + S +G D +K+LR
Sbjct: 1290 TFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNS-KGKDINTIKSLRV 1348
Query: 574 FRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTC 753
RVLRPL+ + +P L+ V + ++ ++ + +I ++ + + I+A++ ++LF GK C
Sbjct: 1349 LRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFH-C 1407
Query: 754 IDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDN 933
D + + +KD E + K + + W+ ++DN
Sbjct: 1408 TDES--KEFEKDCRGKYLLYEKNEVKARDRE--------WKKYE-----------FHYDN 1446
Query: 934 FGLAMLTVFQCVSLEGWTDVMYWVNDAV---------GREWPWIYFVTLVILGSFFVLNL 1086
A+LT+F + EGW V+ DA R I++V ++ FF +N+
Sbjct: 1447 VLWALLTLFTVSTAEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNI 1506
Query: 1087 VLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEP 1266
+ ++ F ++ + K E+ LE++ + +D+ A+ +
Sbjct: 1507 FVALIIITFQEQGD---------KMMEEYSLEKNERACIDFAISAKPL------------ 1545
Query: 1267 VAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXX 1446
+ + + V S F +
Sbjct: 1546 -----------------------------TRHMPQNKQSFQYRMWQFVVSPPFEYTIMAM 1576
Query: 1447 XXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDC 1626
+ YG S ++ + N+ F LFS+E +LK + G Y +N FD
Sbjct: 1577 IALNTIVLMMKFYGASVAYENALRVFNIAFTSLFSLECVLKAMAFGILNYFRDAWNIFDF 1636
Query: 1627 FVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXX 1806
V+ SI + ++ F + +S LR R R+ K+ +
Sbjct: 1637 VTVLGSITDILVTEFG-NNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPY 1695
Query: 1807 XXXXXXXXXXXXXXXGMQVFGG--------KFNFNPQQPKPRANFDTFVQALLTVFQILT 1962
GMQVFG + + Q NF TF QAL+ +F+ T
Sbjct: 1696 VCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSAT 1755
Query: 1963 GEDWNTVMYHGI-----ESFGGVGT--LGVIVCIYYIV--LFICGNYILLNVFLAIAVDN 2115
GE W+ +M + + G+ T G +Y V +F+C ++++LN+F+A+ +DN
Sbjct: 1756 GEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1814
Score = 120 bits (300), Expect = 5e-25
Identities = 73/274 (26%), Positives = 139/274 (50%), Gaps = 4/274 (1%)
Frame = +1
Query: 3313 RLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEA 3492
R+++ + V ++AF + + ++ +NT+ +A HY DFL IF G+F E
Sbjct: 475 RMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEM 534
Query: 3493 VLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVK 3672
+K+ L + Y +N FD V++GS ++ + + PG + I+ R R++R+ K
Sbjct: 535 FIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTS--FGISVLRALRLLRIFK 592
Query: 3673 LLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNN 3849
+ +R L+ + + S +++ + L+ L ++A++GMQ F G+ D+ T
Sbjct: 593 VTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTP---PT 649
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FPAAI+ +F+ TGE W ++M + ++ +GG+ G
Sbjct: 650 NFDTFPAAIMTVFQILTGEDWNEVMY-----DGIK--------SQGGVQ----GGMVFSI 692
Query: 4030 YFISFFMLCSFLVINLFVAVIMDNF---DYLTRD 4122
YFI + ++ ++N+F+A+ +DN LT+D
Sbjct: 693 YFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 726
Score = 92.4 bits (228), Expect = 1e-16
Identities = 72/296 (24%), Positives = 128/296 (42%), Gaps = 13/296 (4%)
Frame = +1
Query: 265 PFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFM 444
PFE+ I+ MI N I L + + Y+N L F +F++ECVLK +A G +
Sbjct: 1568 PFEYTIMAMIALNTIVLMM--KFYGASVAYENAL-RVFNIAFTSLFSLECVLKAMAFGIL 1624
Query: 445 FHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQ 624
Y R+AWNI DF+ V+ + ++++ ++ LR FR R ++L+ +++
Sbjct: 1625 ----NYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIR 1680
Query: 625 VVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCG 804
++L +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1681 ILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF------------------------- 1715
Query: 805 TDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGW 984
N+G+ E + NF F A++ +F+ + E W
Sbjct: 1716 ----------------GNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAW 1759
Query: 985 TDVMYWV--------NDAV-----GREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
++M N + G E+ + YFV+ + L SF +LNL + V+ F
Sbjct: 1760 HNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1815
Score = 86.7 bits (213), Expect = 6e-15
Identities = 70/263 (26%), Positives = 117/263 (43%), Gaps = 13/263 (4%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLF+ S N R + + F +L I+ + +LA E L + M L+
Sbjct: 77 SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSL-----TSFVLRTDAM 2667
+ +F +F E +K+I G FHKGS+ RN +N++D +VV + T F LRT
Sbjct: 137 EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRT--- 193
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
++ L+ V++ ++ A+ + I L+ F +FAIIG++ +
Sbjct: 194 -----LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFY 248
Query: 2848 KGTFFL------CNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAM 3009
G F +D+ + A C E + TK +N FDN+ A+
Sbjct: 249 MGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAV 308
Query: 3010 ISLFVVSTFEGWPQLLYVAIDSN 3078
+++F T EGW LLY + D++
Sbjct: 309 LTVFQCITMEGWTDLLYNSNDAS 331
Score = 80.9 bits (198), Expect = 3e-13
Identities = 75/293 (25%), Positives = 123/293 (41%), Gaps = 43/293 (14%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY+I I+ N + LA + H P + LD F G+F FEA +KI+AL
Sbjct: 100 FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WNV D +VV+ G L GT + R RV+R +KL+S
Sbjct: 160 HKGSYLRNGWNVMDFVVVL-------TGILATVGTE-FDLRTLRAVRVLRPLKLVSGIPS 211
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQF----FGKVALDDSTSIHR------ 3843
++ +L + MK+ L + LL+ I+A+IG++F F ++ T +
Sbjct: 212 LQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAP 271
Query: 3844 -----------------------NN---NFHSFPAAILVLFRSATGEAWQDIMLSCSDRE 3945
NN F + A+L +F+ T E W D++ + +D
Sbjct: 272 CGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDAS 331
Query: 3946 DVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
GN + + YFI ++ SF ++NL + V+ F
Sbjct: 332 ---------------------GNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 363
Score = 75.9 bits (185), Expect = 1e-11
Identities = 72/322 (22%), Positives = 140/322 (43%), Gaps = 16/322 (4%)
Frame = +1
Query: 250 IVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIV 429
+V+ + F + +L ++ N + +AI ++ + L E++F+ +F E +K+
Sbjct: 483 MVKTQAFYWTVLSLVALNTLCVAIVH---YNQPEWLSDFLYYAEFIFLGLFMSEMFIKMY 539
Query: 430 AMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKALRAFRVLRPLRLV 603
+G Y +++N D V+IG + ++ + G F + LRA R+LR ++
Sbjct: 540 GLG----TRPYFHSSFNCFD-CGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVT 594
Query: 604 SGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ 783
SL+ ++ ++L +M ++ + L+ I+++A++G++LF GQ
Sbjct: 595 KYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLF------------GGQFNF 642
Query: 784 KDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQ 963
+ TP TNFD F A++TVFQ
Sbjct: 643 DEGTPP---------------------------------------TNFDTFPAAIMTVFQ 663
Query: 964 CVSLEGWTDVMY-WVNDAVGREWPW---IYFVTLVILGSFFVLNLVLGV----------L 1101
++ E W +VMY + G + IYF+ L + G++ +LN+ L + L
Sbjct: 664 ILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQEL 723
Query: 1102 SGEFSKEREKARARGLFQKFRE 1167
+ + +E E A + QK +E
Sbjct: 724 TKDEQEEEEAANQKLALQKAKE 745
Score = 46.2 bits (108), Expect = 0.009
Identities = 50/264 (18%), Positives = 103/264 (38%), Gaps = 3/264 (1%)
Frame = +1
Query: 2293 AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN 2472
A +++K +S F R + +V F VL + +++ +A Q
Sbjct: 454 ARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPE 513
Query: 2473 STRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL 2652
+ L Y ++ F +F E+ +K+ G + ++FN D V+ S+ +
Sbjct: 514 WLSDF-LYYAEFIFLGLFMSEMFIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIW 568
Query: 2653 RTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
K L+++V ++ ++K+I +++ + F+ +F
Sbjct: 569 AVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
Query: 2824 AIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGD 3003
A++G+QLF G F ++++G P NFD
Sbjct: 629 ALLGMQLFGGQF-------------------NFDEGTPPT-------------NFDTFPA 656
Query: 3004 AMISLFVVSTFEGWPQLLYVAIDS 3075
A++++F + T E W +++Y I S
Sbjct: 657 AIMTVFQILTGEDWNEVMYDGIKS 680
>gi|2136950|pir||I46480 calcium channel BI-2 - rabbit
gi|1529|emb|CAA40872.1| calcium channel BI-2 [Oryctolagus cuniculus]
Length = 2424
Score = 676 bits (1744), Expect = 0.0
Identities = 354/787 (44%), Positives = 498/787 (62%), Gaps = 17/787 (2%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
+ + E P KP+P SS+FILS TN R C+ ++N YF +L I +SS L
Sbjct: 1211 KKEEVDEGPGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIAL 1270
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP+Q N+ RN +L YFDY FT VFT E+ +K+I GLV H+G++ R+ +N+LD +VV
Sbjct: 1271 AAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVV 1330
Query: 2626 AVSLTSFVLRTDA----MSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIM 2793
+ +L +F ++ ++ I R LK V CV+ ++K + NI+
Sbjct: 1331 SGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNIL 1390
Query: 2794 LVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSN 2973
+V + F+FA++ VQLFKG FF C D SK E +CRG+Y+ YE + ++ R W
Sbjct: 1391 IVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVK---ARDREWKK 1447
Query: 2974 NDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXX 3153
+F++DNV A+++LF VST EGWPQ+L ++D+ E++GP R +++
Sbjct: 1448 YEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVF 1507
Query: 3154 XXXXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYR 3327
+I+TFQ +G++ E L+KN+R CI+FA+ AKP R++P+N+ QYR
Sbjct: 1508 PFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYR 1567
Query: 3328 VWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIV 3507
+W FV S FEY I +I +NT+ L K Y +S +++ L VFN++FT +F+ E +LK++
Sbjct: 1568 MWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYDNALKVFNIVFTSLFSLECLLKVL 1627
Query: 3508 ALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRG 3687
A NY D WN+FD + V+GS DI + G N I+++F RLFR RL+KLL +G
Sbjct: 1628 AFGILNYFRDAWNIFDFVTVLGSITDILVTEF---GNNFINLSFLRLFRAARLIKLLRQG 1684
Query: 3688 EGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALD--------DSTSIHR 3843
IR LLWTF++SF+ALPYV LLI +LFFIYA+IGMQ FG + +D D I
Sbjct: 1685 YTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDMEDEDSDEDEFQITE 1744
Query: 3844 NNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFA 4023
+NNF +F A+++LFRSATGEAW +IMLSC + CD S G+ CGN FA
Sbjct: 1745 HNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKP--CDKNS------GILTPECGNEFA 1796
Query: 4024 YPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRI 4203
Y YF+SF LCSFL++NLFVAVIMDNF+YLTRD SILGPHHL+E+VR+W+EYDP A GR+
Sbjct: 1797 YFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAAWGRM 1856
Query: 4204 KHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKI 4383
+ D+ +LLR ISPPLG GK CPHR+ACKRL+ M++P+ D TV FN+TL AL+RT L I
Sbjct: 1857 HYKDMYSLLRVISPPLGLGKKCPHRVACKRLLRMDLPVADDNTVHFNSTLMALIRTALDI 1916
Query: 4384 -YTEGNID--EANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYF 4554
+G D + + +LR + IW + LD +V P K D+TVGK YA +I +Y+
Sbjct: 1917 KIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTP-HKSTDLTVGKIYAAMMIMEYY 1975
Query: 4555 RRFKKRK 4575
R+ K +K
Sbjct: 1976 RQSKAKK 1982
Score = 534 bits (1376), Expect = e-150
Identities = 294/667 (44%), Positives = 383/667 (57%), Gaps = 27/667 (4%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N +RK I EW PFE++IL I ANCI LA+ Q P D + L+ E FI +
Sbjct: 84 DNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGI 143
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KI+A+GF FH +YLRN WN++DF++V+ G+++T+ ++ FD++ LRA R
Sbjct: 144 FCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE-----FDLRTLRAVR 198
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQVVL +I++AMIPLL I LL+ F ILI+AIIGLE + GK H+TC +
Sbjct: 199 VLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFE 258
Query: 760 PATGQLAQKDPTPCGTD----TEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNF 927
T + + P PCGT+ T + +CQP W GPNNGIT F
Sbjct: 259 EGTDDIQGESPAPCGTEEPARTCPNGTRCQPY-----------------WEGPNNGITQF 301
Query: 928 DNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSG 1107
DN A+LTVFQC+++EGWTD++Y NDA G W W+YF+ L+I+GSFF+LNLVLGVLSG
Sbjct: 302 DNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSG 361
Query: 1108 EFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVAQTXXX 1287
EF+KERE+ R F K R +QQ+E +L GY++WI++AE++ + EDE + E
Sbjct: 362 EFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEV-ILAEDETDVEQRHPFDGA 420
Query: 1288 XXXXXXXXXXXXXXXP-----------------SKWAARMKRLE------KLNXXXXXXX 1398
P ++ + + +LE K
Sbjct: 421 LRRATIKKSKTDLLHPEEAEDQLADIASVGSPFARASIKSAKLENSSFFHKKERRMRFYI 480
Query: 1399 XXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYS 1578
+VK+Q FYW HY Q EWL F A F+ LF EM +KMY
Sbjct: 481 RRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYG 540
Query: 1579 LGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXX 1758
LG Y S FN FDC V+I SI E + G+SVLR+ RLLRIFKVTKYW
Sbjct: 541 LGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASL 600
Query: 1759 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQAL 1938
GMQ+FGG+FNF+ + P NFDTF A+
Sbjct: 601 RNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFD--EGTPPTNFDTFPAAI 658
Query: 1939 LTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNL 2118
+TVFQILTGEDWN VMY GI+S GGV G++ IY+IVL + GNY LLNVFLAIAVDNL
Sbjct: 659 MTVFQILTGEDWNEVMYDGIKSQGGVQG-GMVFSIYFIVLTLFGNYTLLNVFLAIAVDNL 717
Query: 2119 ADADSLT 2139
A+A LT
Sbjct: 718 ANAQELT 724
Score = 171 bits (433), Expect = 2e-40
Identities = 161/660 (24%), Positives = 278/660 (41%), Gaps = 29/660 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+R+LC I+ + FE IL +I + IALA P Q + +N +L +YVF VF
Sbjct: 1240 NPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDP--VQPNAPRNNVLRYFDYVFTGVF 1297
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD---VKALRA 573
T E V+K++ +G + H AY R+ WNILDFI+V LV+ + S +G D +K+LR
Sbjct: 1298 TFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNS-KGKDINTIKSLRV 1356
Query: 574 FRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTC 753
RVLRPL+ + +P L+ V + ++ ++ + +I ++ + + I+A++ ++LF GK C
Sbjct: 1357 LRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFH-C 1415
Query: 754 IDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDN 933
D + + +KD E + K + + W+ ++DN
Sbjct: 1416 TDES--KEFEKDCRGKYLLYEKNEVKARDRE--------WKKYE-----------FHYDN 1454
Query: 934 FGLAMLTVFQCVSLEGWTDVMYWVNDAV---------GREWPWIYFVTLVILGSFFVLNL 1086
A+LT+F + EGW V+ DA R I++V ++ FF +N+
Sbjct: 1455 VLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNI 1514
Query: 1087 VLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEP 1266
+ ++ F ++ + K E+ LE++ + +D+ A+ +
Sbjct: 1515 FVALIIITFQEQGD---------KMMEEYSLEKNERACIDFAISAKPL------------ 1553
Query: 1267 VAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXX 1446
+ + + V S F +
Sbjct: 1554 -----------------------------TRHMPQNKQSFQYRMWQFVVSPPFEYTIMAM 1584
Query: 1447 XXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDC 1626
+ YG S D+ + N+ F LFS+E LLK+ + G Y +N FD
Sbjct: 1585 IALNTIVLMMKFYGASVAYDNALKVFNIVFTSLFSLECLLKVLAFGILNYFRDAWNIFDF 1644
Query: 1627 FVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXX 1806
V+ SI + ++ F + +S LR R R+ K+ +
Sbjct: 1645 VTVLGSITDILVTEFG-NNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPY 1703
Query: 1807 XXXXXXXXXXXXXXXGMQVFGG--------KFNFNPQQPKPRANFDTFVQALLTVFQILT 1962
GMQVFG + + Q NF TF QAL+ +F+ T
Sbjct: 1704 VCLLIAMLFFIYAIIGMQVFGNIGIDMEDEDSDEDEFQITEHNNFRTFFQALMLLFRSAT 1763
Query: 1963 GEDWNTVMYHGI-----ESFGGVGT--LGVIVCIYYIV--LFICGNYILLNVFLAIAVDN 2115
GE W+ +M + + G+ T G +Y V +F+C ++++LN+F+A+ +DN
Sbjct: 1764 GEAWHNIMLSCLSGKPCDKNSGILTPECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1822
Score = 120 bits (300), Expect = 5e-25
Identities = 73/274 (26%), Positives = 139/274 (50%), Gaps = 4/274 (1%)
Frame = +1
Query: 3313 RLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEA 3492
R+++ + V ++AF + + ++ +NT+ +A HY DFL IF G+F E
Sbjct: 475 RMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEM 534
Query: 3493 VLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVK 3672
+K+ L + Y +N FD V++GS ++ + + PG + I+ R R++R+ K
Sbjct: 535 FIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTS--FGISVLRALRLLRIFK 592
Query: 3673 LLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNN 3849
+ +R L+ + + S +++ + L+ L ++A++GMQ F G+ D+ T
Sbjct: 593 VTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTP---PT 649
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FPAAI+ +F+ TGE W ++M + ++ +GG+ G
Sbjct: 650 NFDTFPAAIMTVFQILTGEDWNEVMY-----DGIK--------SQGGVQ----GGMVFSI 692
Query: 4030 YFISFFMLCSFLVINLFVAVIMDNF---DYLTRD 4122
YFI + ++ ++N+F+A+ +DN LT+D
Sbjct: 693 YFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 726
Score = 95.1 bits (235), Expect = 2e-17
Identities = 71/296 (23%), Positives = 129/296 (42%), Gaps = 13/296 (4%)
Frame = +1
Query: 265 PFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFM 444
PFE+ I+ MI N I L + + Y N L + VF +F++EC+LK++A G +
Sbjct: 1576 PFEYTIMAMIALNTIVLMM--KFYGASVAYDNAL-KVFNIVFTSLFSLECLLKVLAFGIL 1632
Query: 445 FHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQ 624
Y R+AWNI DF+ V+ + ++++ ++ LR FR R ++L+ +++
Sbjct: 1633 ----NYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIR 1688
Query: 625 VVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCG 804
++L +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1689 ILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF------------------------- 1723
Query: 805 TDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGW 984
N+G+ E + NF F A++ +F+ + E W
Sbjct: 1724 ----------------GNIGIDMEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAW 1767
Query: 985 TDVMYW-------------VNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
++M + G E+ + YFV+ + L SF +LNL + V+ F
Sbjct: 1768 HNIMLSCLSGKPCDKNSGILTPECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1823
Score = 85.5 bits (210), Expect = 1e-14
Identities = 69/263 (26%), Positives = 117/263 (44%), Gaps = 13/263 (4%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLF+ S N R + + F +L I+ + +LA E L + M L+
Sbjct: 77 SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSL-----TSFVLRTDAM 2667
+ +F +F E +K+I G FHKGS+ RN +N++D +VV + T F LRT
Sbjct: 137 EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRT--- 193
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
++ L+ V++ ++ A+ + I L+ F +FAIIG++ +
Sbjct: 194 -----LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFY 248
Query: 2848 KGTFFL------CNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAM 3009
G F +D+ + A C E + T+ +N FDN+ A+
Sbjct: 249 MGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTRCQPYWEGPNNGITQFDNILFAV 308
Query: 3010 ISLFVVSTFEGWPQLLYVAIDSN 3078
+++F T EGW LLY + D++
Sbjct: 309 LTVFQCITMEGWTDLLYNSNDAS 331
Score = 80.9 bits (198), Expect = 3e-13
Identities = 75/293 (25%), Positives = 123/293 (41%), Gaps = 43/293 (14%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY+I I+ N + LA + H P + LD F G+F FEA +KI+AL
Sbjct: 100 FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WNV D +VV+ G L GT + R RV+R +KL+S
Sbjct: 160 HKGSYLRNGWNVMDFVVVL-------TGILATVGTE-FDLRTLRAVRVLRPLKLVSGIPS 211
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQF----FGKVALDDSTSIHR------ 3843
++ +L + MK+ L + LL+ I+A+IG++F F ++ T +
Sbjct: 212 LQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAP 271
Query: 3844 -----------------------NN---NFHSFPAAILVLFRSATGEAWQDIMLSCSDRE 3945
NN F + A+L +F+ T E W D++ + +D
Sbjct: 272 CGTEEPARTCPNGTRCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDAS 331
Query: 3946 DVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
GN + + YFI ++ SF ++NL + V+ F
Sbjct: 332 ---------------------GNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 363
Score = 45.8 bits (107), Expect = 0.012
Identities = 50/264 (18%), Positives = 103/264 (38%), Gaps = 3/264 (1%)
Frame = +1
Query: 2293 AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN 2472
A +++K +S F R + +V F VL + +++ +A Q
Sbjct: 454 ARASIKSAKLENSSFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPE 513
Query: 2473 STRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL 2652
+ L Y ++ F +F E+ +K+ G + ++FN D V+ S+ +
Sbjct: 514 WLSDF-LYYAEFIFLGLFMSEMFIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIW 568
Query: 2653 RTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
K L+++V ++ ++K+I +++ + F+ +F
Sbjct: 569 AVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
Query: 2824 AIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGD 3003
A++G+QLF G F ++++G P NFD
Sbjct: 629 ALLGMQLFGGQF-------------------NFDEGTPPT-------------NFDTFPA 656
Query: 3004 AMISLFVVSTFEGWPQLLYVAIDS 3075
A++++F + T E W +++Y I S
Sbjct: 657 AIMTVFQILTGEDWNEVMYDGIKS 680
>gi|1525|emb|CAA40871.1| calcium channel BI-1 [Oryctolagus cuniculus]
Length = 2273
Score = 676 bits (1744), Expect = 0.0
Identities = 354/787 (44%), Positives = 498/787 (62%), Gaps = 17/787 (2%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
+ + E P KP+P SS+FILS TN R C+ ++N YF +L I +SS L
Sbjct: 1211 KKEEVDEGPGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIAL 1270
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP+Q N+ RN +L YFDY FT VFT E+ +K+I GLV H+G++ R+ +N+LD +VV
Sbjct: 1271 AAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVV 1330
Query: 2626 AVSLTSFVLRTDA----MSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIM 2793
+ +L +F ++ ++ I R LK V CV+ ++K + NI+
Sbjct: 1331 SGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNIL 1390
Query: 2794 LVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSN 2973
+V + F+FA++ VQLFKG FF C D SK E +CRG+Y+ YE + ++ R W
Sbjct: 1391 IVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVK---ARDREWKK 1447
Query: 2974 NDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXX 3153
+F++DNV A+++LF VST EGWPQ+L ++D+ E++GP R +++
Sbjct: 1448 YEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVF 1507
Query: 3154 XXXXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYR 3327
+I+TFQ +G++ E L+KN+R CI+FA+ AKP R++P+N+ QYR
Sbjct: 1508 PFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYR 1567
Query: 3328 VWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIV 3507
+W FV S FEY I +I +NT+ L K Y +S +++ L VFN++FT +F+ E +LK++
Sbjct: 1568 MWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYDNALKVFNIVFTSLFSLECLLKVL 1627
Query: 3508 ALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRG 3687
A NY D WN+FD + V+GS DI + G N I+++F RLFR RL+KLL +G
Sbjct: 1628 AFGILNYFRDAWNIFDFVTVLGSITDILVTEF---GNNFINLSFLRLFRAARLIKLLRQG 1684
Query: 3688 EGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALD--------DSTSIHR 3843
IR LLWTF++SF+ALPYV LLI +LFFIYA+IGMQ FG + +D D I
Sbjct: 1685 YTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDMEDEDSDEDEFQITE 1744
Query: 3844 NNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFA 4023
+NNF +F A+++LFRSATGEAW +IMLSC + CD S G+ CGN FA
Sbjct: 1745 HNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKP--CDKNS------GILTPECGNEFA 1796
Query: 4024 YPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRI 4203
Y YF+SF LCSFL++NLFVAVIMDNF+YLTRD SILGPHHL+E+VR+W+EYDP A GR+
Sbjct: 1797 YFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAAWGRM 1856
Query: 4204 KHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKI 4383
+ D+ +LLR ISPPLG GK CPHR+ACKRL+ M++P+ D TV FN+TL AL+RT L I
Sbjct: 1857 HYKDMYSLLRVISPPLGLGKKCPHRVACKRLLRMDLPVADDNTVHFNSTLMALIRTALDI 1916
Query: 4384 -YTEGNID--EANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYF 4554
+G D + + +LR + IW + LD +V P K D+TVGK YA +I +Y+
Sbjct: 1917 KIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTP-HKSTDLTVGKIYAAMMIMEYY 1975
Query: 4555 RRFKKRK 4575
R+ K +K
Sbjct: 1976 RQSKAKK 1982
Score = 534 bits (1376), Expect = e-150
Identities = 294/667 (44%), Positives = 383/667 (57%), Gaps = 27/667 (4%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N +RK I EW PFE++IL I ANCI LA+ Q P D + L+ E FI +
Sbjct: 84 DNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGI 143
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KI+A+GF FH +YLRN WN++DF++V+ G+++T+ ++ FD++ LRA R
Sbjct: 144 FCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE-----FDLRTLRAVR 198
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQVVL +I++AMIPLL I LL+ F ILI+AIIGLE + GK H+TC +
Sbjct: 199 VLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFE 258
Query: 760 PATGQLAQKDPTPCGTD----TEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNF 927
T + + P PCGT+ T + +CQP W GPNNGIT F
Sbjct: 259 EGTDDIQGESPAPCGTEEPARTCPNGTRCQPY-----------------WEGPNNGITQF 301
Query: 928 DNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSG 1107
DN A+LTVFQC+++EGWTD++Y NDA G W W+YF+ L+I+GSFF+LNLVLGVLSG
Sbjct: 302 DNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSG 361
Query: 1108 EFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVAQTXXX 1287
EF+KERE+ R F K R +QQ+E +L GY++WI++AE++ + EDE + E
Sbjct: 362 EFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEV-ILAEDETDVEQRHPFDGA 420
Query: 1288 XXXXXXXXXXXXXXXP-----------------SKWAARMKRLE------KLNXXXXXXX 1398
P ++ + + +LE K
Sbjct: 421 LRRATIKKSKTDLLHPEEAEDQLADIASVGSPFARASIKSAKLENSSFFHKKERRMRFYI 480
Query: 1399 XXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYS 1578
+VK+Q FYW HY Q EWL F A F+ LF EM +KMY
Sbjct: 481 RRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYG 540
Query: 1579 LGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXX 1758
LG Y S FN FDC V+I SI E + G+SVLR+ RLLRIFKVTKYW
Sbjct: 541 LGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASL 600
Query: 1759 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQAL 1938
GMQ+FGG+FNF+ + P NFDTF A+
Sbjct: 601 RNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFD--EGTPPTNFDTFPAAI 658
Query: 1939 LTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNL 2118
+TVFQILTGEDWN VMY GI+S GGV G++ IY+IVL + GNY LLNVFLAIAVDNL
Sbjct: 659 MTVFQILTGEDWNEVMYDGIKSQGGVQG-GMVFSIYFIVLTLFGNYTLLNVFLAIAVDNL 717
Query: 2119 ADADSLT 2139
A+A LT
Sbjct: 718 ANAQELT 724
Score = 171 bits (433), Expect = 2e-40
Identities = 161/660 (24%), Positives = 278/660 (41%), Gaps = 29/660 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+R+LC I+ + FE IL +I + IALA P Q + +N +L +YVF VF
Sbjct: 1240 NPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDP--VQPNAPRNNVLRYFDYVFTGVF 1297
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD---VKALRA 573
T E V+K++ +G + H AY R+ WNILDFI+V LV+ + S +G D +K+LR
Sbjct: 1298 TFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNS-KGKDINTIKSLRV 1356
Query: 574 FRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTC 753
RVLRPL+ + +P L+ V + ++ ++ + +I ++ + + I+A++ ++LF GK C
Sbjct: 1357 LRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFH-C 1415
Query: 754 IDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDN 933
D + + +KD E + K + + W+ ++DN
Sbjct: 1416 TDES--KEFEKDCRGKYLLYEKNEVKARDRE--------WKKYE-----------FHYDN 1454
Query: 934 FGLAMLTVFQCVSLEGWTDVMYWVNDAV---------GREWPWIYFVTLVILGSFFVLNL 1086
A+LT+F + EGW V+ DA R I++V ++ FF +N+
Sbjct: 1455 VLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNI 1514
Query: 1087 VLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEP 1266
+ ++ F ++ + K E+ LE++ + +D+ A+ +
Sbjct: 1515 FVALIIITFQEQGD---------KMMEEYSLEKNERACIDFAISAKPL------------ 1553
Query: 1267 VAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXX 1446
+ + + V S F +
Sbjct: 1554 -----------------------------TRHMPQNKQSFQYRMWQFVVSPPFEYTIMAM 1584
Query: 1447 XXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDC 1626
+ YG S D+ + N+ F LFS+E LLK+ + G Y +N FD
Sbjct: 1585 IALNTIVLMMKFYGASVAYDNALKVFNIVFTSLFSLECLLKVLAFGILNYFRDAWNIFDF 1644
Query: 1627 FVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXX 1806
V+ SI + ++ F + +S LR R R+ K+ +
Sbjct: 1645 VTVLGSITDILVTEFG-NNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPY 1703
Query: 1807 XXXXXXXXXXXXXXXGMQVFGG--------KFNFNPQQPKPRANFDTFVQALLTVFQILT 1962
GMQVFG + + Q NF TF QAL+ +F+ T
Sbjct: 1704 VCLLIAMLFFIYAIIGMQVFGNIGIDMEDEDSDEDEFQITEHNNFRTFFQALMLLFRSAT 1763
Query: 1963 GEDWNTVMYHGI-----ESFGGVGT--LGVIVCIYYIV--LFICGNYILLNVFLAIAVDN 2115
GE W+ +M + + G+ T G +Y V +F+C ++++LN+F+A+ +DN
Sbjct: 1764 GEAWHNIMLSCLSGKPCDKNSGILTPECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1822
Score = 120 bits (300), Expect = 5e-25
Identities = 73/274 (26%), Positives = 139/274 (50%), Gaps = 4/274 (1%)
Frame = +1
Query: 3313 RLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEA 3492
R+++ + V ++AF + + ++ +NT+ +A HY DFL IF G+F E
Sbjct: 475 RMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEM 534
Query: 3493 VLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVK 3672
+K+ L + Y +N FD V++GS ++ + + PG + I+ R R++R+ K
Sbjct: 535 FIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTS--FGISVLRALRLLRIFK 592
Query: 3673 LLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNN 3849
+ +R L+ + + S +++ + L+ L ++A++GMQ F G+ D+ T
Sbjct: 593 VTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTP---PT 649
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FPAAI+ +F+ TGE W ++M + ++ +GG+ G
Sbjct: 650 NFDTFPAAIMTVFQILTGEDWNEVMY-----DGIK--------SQGGVQ----GGMVFSI 692
Query: 4030 YFISFFMLCSFLVINLFVAVIMDNF---DYLTRD 4122
YFI + ++ ++N+F+A+ +DN LT+D
Sbjct: 693 YFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 726
Score = 95.1 bits (235), Expect = 2e-17
Identities = 71/296 (23%), Positives = 129/296 (42%), Gaps = 13/296 (4%)
Frame = +1
Query: 265 PFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFM 444
PFE+ I+ MI N I L + + Y N L + VF +F++EC+LK++A G +
Sbjct: 1576 PFEYTIMAMIALNTIVLMM--KFYGASVAYDNAL-KVFNIVFTSLFSLECLLKVLAFGIL 1632
Query: 445 FHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQ 624
Y R+AWNI DF+ V+ + ++++ ++ LR FR R ++L+ +++
Sbjct: 1633 ----NYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIR 1688
Query: 625 VVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCG 804
++L +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1689 ILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF------------------------- 1723
Query: 805 TDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGW 984
N+G+ E + NF F A++ +F+ + E W
Sbjct: 1724 ----------------GNIGIDMEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAW 1767
Query: 985 TDVMYW-------------VNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
++M + G E+ + YFV+ + L SF +LNL + V+ F
Sbjct: 1768 HNIMLSCLSGKPCDKNSGILTPECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1823
Score = 85.5 bits (210), Expect = 1e-14
Identities = 69/263 (26%), Positives = 117/263 (44%), Gaps = 13/263 (4%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLF+ S N R + + F +L I+ + +LA E L + M L+
Sbjct: 77 SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSL-----TSFVLRTDAM 2667
+ +F +F E +K+I G FHKGS+ RN +N++D +VV + T F LRT
Sbjct: 137 EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRT--- 193
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
++ L+ V++ ++ A+ + I L+ F +FAIIG++ +
Sbjct: 194 -----LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFY 248
Query: 2848 KGTFFL------CNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAM 3009
G F +D+ + A C E + T+ +N FDN+ A+
Sbjct: 249 MGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTRCQPYWEGPNNGITQFDNILFAV 308
Query: 3010 ISLFVVSTFEGWPQLLYVAIDSN 3078
+++F T EGW LLY + D++
Sbjct: 309 LTVFQCITMEGWTDLLYNSNDAS 331
Score = 80.9 bits (198), Expect = 3e-13
Identities = 75/293 (25%), Positives = 123/293 (41%), Gaps = 43/293 (14%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY+I I+ N + LA + H P + LD F G+F FEA +KI+AL
Sbjct: 100 FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WNV D +VV+ G L GT + R RV+R +KL+S
Sbjct: 160 HKGSYLRNGWNVMDFVVVL-------TGILATVGTE-FDLRTLRAVRVLRPLKLVSGIPS 211
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQF----FGKVALDDSTSIHR------ 3843
++ +L + MK+ L + LL+ I+A+IG++F F ++ T +
Sbjct: 212 LQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAP 271
Query: 3844 -----------------------NN---NFHSFPAAILVLFRSATGEAWQDIMLSCSDRE 3945
NN F + A+L +F+ T E W D++ + +D
Sbjct: 272 CGTEEPARTCPNGTRCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDAS 331
Query: 3946 DVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
GN + + YFI ++ SF ++NL + V+ F
Sbjct: 332 ---------------------GNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 363
Score = 45.8 bits (107), Expect = 0.012
Identities = 50/264 (18%), Positives = 103/264 (38%), Gaps = 3/264 (1%)
Frame = +1
Query: 2293 AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN 2472
A +++K +S F R + +V F VL + +++ +A Q
Sbjct: 454 ARASIKSAKLENSSFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPE 513
Query: 2473 STRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL 2652
+ L Y ++ F +F E+ +K+ G + ++FN D V+ S+ +
Sbjct: 514 WLSDF-LYYAEFIFLGLFMSEMFIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIW 568
Query: 2653 RTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
K L+++V ++ ++K+I +++ + F+ +F
Sbjct: 569 AVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
Query: 2824 AIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGD 3003
A++G+QLF G F ++++G P NFD
Sbjct: 629 ALLGMQLFGGQF-------------------NFDEGTPPT-------------NFDTFPA 656
Query: 3004 AMISLFVVSTFEGWPQLLYVAIDS 3075
A++++F + T E W +++Y I S
Sbjct: 657 AIMTVFQILTGEDWNEVMYDGIKS 680
>gi|192324|gb|AAB59700.1| dihydropyridine sensitive calcium channel
Length = 1351
Score = 676 bits (1743), Expect = 0.0
Identities = 352/659 (53%), Positives = 441/659 (66%), Gaps = 18/659 (2%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+RK CISIVEWKPFE +IL I ANC+ALA+Y P P D++ N LE +EY F++VF
Sbjct: 38 NPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNTLNLGLEKLEYFFLIVF 97
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSI------------Q 546
+IE +KI+A GF+FH AYLR+ WN+LDFIIV +G+ + IL +++I
Sbjct: 98 SIEAAMKIIAYGFLFHQDAYLRSGWNVLDFIIVFLGVFTVILEQVNIIQTNTAPMSSKGA 157
Query: 547 GFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLEL 726
G DVKALRAFRVLRPLRLVSGVPSLQVVLN+I +AM+PL HIALLVLF+++IYAIIGLEL
Sbjct: 158 GLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLEL 217
Query: 727 FCGKLHSTCIDPATGQLA---QKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTW 897
F GK+H TC T +A + P+PC GS C + S EC W
Sbjct: 218 FKGKMHKTCYFIGTDIVATVENEKPSPCART--GSGRPCTINGS--------ECRGG--W 265
Query: 898 PGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFV 1077
PGPN+GIT+FDNFG +MLTV+QC+S+EGWTDV+YWVNDA+G EWPWIYFVTL++LGSFF+
Sbjct: 266 PGPNHGITHFDNFGFSMLTVYQCISMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFI 325
Query: 1078 LNLVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAE--DIEPVNEDE 1251
LNLVLGVLSGEF+KEREKA++RG FQK REKQQLEEDL+GY+ WITQ E D++ + E +
Sbjct: 326 LNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLEEDLRGYMSWITQGEVMDVDDLREGK 385
Query: 1252 QE-DEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFY 1428
DE + T +K ++ + N LVKS+ FY
Sbjct: 386 LSLDEGGSDTESLYEIEGL----------NKIIQFIRHWRQWNRVFRWKCHDLVKSKVFY 435
Query: 1429 WXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQ 1608
W SEH+ Q WL H Q +AN + LF++EML+KMY LG Y S
Sbjct: 436 WLVILIVALNTLSIASEHHNQPLWLTHLQDVANRVLLTLFTIEMLMKMYGLGLRQYFMSI 495
Query: 1609 FNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXX 1788
FNRFDCFVV S ILE +LV M PLG+SVLR RLLR+FK+TKYWT
Sbjct: 496 FNRFDCFVVCSGILEILLVESGAMSPLGISVLRCIRLLRLFKITKYWTSLSNLVASLLNS 555
Query: 1789 XXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGE 1968
GMQ+FGG+++F + + R+NFD F QAL++VFQ+LTGE
Sbjct: 556 IRSIASLLLLLFLFIIIFALLGMQLFGGRYDFEDTEVR-RSNFDNFPQALISVFQVLTGE 614
Query: 1969 DWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNA 2145
DWN+VMY+GI ++GG GV+VCIY+I+LF+CGNYILLNVFLAIAVDNLA+A+SLT+A
Sbjct: 615 DWNSVMYNGIMAYGGPTYPGVLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTSA 673
Score = 649 bits (1674), Expect = 0.0
Identities = 328/567 (57%), Positives = 405/567 (70%), Gaps = 6/567 (1%)
Frame = +1
Query: 2260 SARPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSA 2439
S RPR ++E+ PIP+ASS FI S TN RV C+ +VN ++FTN +L IL+SSA
Sbjct: 755 SPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSA 814
Query: 2440 MLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDIL 2619
LAAEDP++A+S RN IL YFDY FT+VFTVEI LK+ +G HKGSFCRN FN+LD+L
Sbjct: 815 ALAAEDPIRADSMRNQILEYFDYVFTAVFTVEIVLKMTTYGAFLHKGSFCRNYFNILDLL 874
Query: 2620 VVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLV 2799
VVAVSL S L + A+S AINRAKGLKHVVQCV VA++TIGNI+LV
Sbjct: 875 VVAVSLISMGLESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVLV 934
Query: 2800 TFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNND 2979
T +LQFMFA IGVQLFKG F+ CNDLSKMTE ECRG Y Y+DGDPT+ + R W +ND
Sbjct: 935 TTLLQFMFACIGVQLFKGKFYSCNDLSKMTEEECRGYYYIYKDGDPTQIELRPRQWIHND 994
Query: 2980 FNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXX 3159
F+FDNV AM+SLF VSTFEGWPQLLY AIDSNEED GP++N+R +A+
Sbjct: 995 FHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNEEDTGPVYNNRVEMAIFFIIYIILIAF 1054
Query: 3160 XXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWF 3339
GFVIVTFQ +GE EY+NCELDKNQR+C+++ALKA+P R YIP+N QY+VW+
Sbjct: 1055 FMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQVWYV 1114
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
VTS FEY++F +I++NT+ L +HY S D+ N+ FT +F E VLK++A P
Sbjct: 1115 VTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMVLKLIAFKP 1174
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKL-NPGGTNLISINFFRLFRVMRLVKLLSRGEGI 3696
+ Y D WNVFD L+V+GS ID+ ++ +P + IS FFRLFRVMRLVKLL+R EG+
Sbjct: 1175 RAYFGDPWNVFDFLIVIGSIIDVILSEIDDPDESARISSAFFRLFRVMRLVKLLNRAEGV 1234
Query: 3697 RTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAI 3876
RTLLWTF+KSFQALPYVALLIV+LFFIYAVIGMQ FGK+A+ D T I+RNNNF +FP A+
Sbjct: 1235 RTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIAMVDGTQINRNNNFQTFPQAV 1294
Query: 3877 LVLFRSATGE-----AWQDIMLSCSDR 3942
L+L G+ W M SC R
Sbjct: 1295 LLLLGVPQGKPGKRSCWPAAMGSCVTR 1321
Score = 168 bits (426), Expect = 1e-39
Identities = 154/671 (22%), Positives = 282/671 (41%), Gaps = 73/671 (10%)
Frame = +1
Query: 2308 KPIPKA-----SSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQA- 2469
KP+P+ +LF L+ N R C +V F +L I + LA P+
Sbjct: 18 KPVPEILPRPPRALFCLTLQNPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPED 77
Query: 2470 -NSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSF 2646
N+T N+ L +YFF VF++E +K+I +G +FH+ ++ R+ +N+LD ++V + + +
Sbjct: 78 DNNTLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFIIVFLGVFTV 137
Query: 2647 VLR--------TDAMSXXXXXXXXXXXXXXXAINRAK------GLKHVVQCVIVAVKTIG 2784
+L T MS + + L+ V+ + A+ +
Sbjct: 138 ILEQVNIIQTNTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLF 197
Query: 2785 NIMLVTFMLQFMFAIIGVQLFKGT-----FFLCNDLSKMTEAECRGEYIHYEDGDP-TKP 2946
+I L+ + ++AIIG++LFKG +F+ D+ E E G P T
Sbjct: 198 HIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEKPSPCARTGSGRPCTIN 257
Query: 2947 VSKKRV-WSNNDF---NFDNVGDAMISLFVVSTFEG---------------WPQLLYVAI 3069
S+ R W + +FDN G +M++++ + EG WP + +V +
Sbjct: 258 GSECRGGWPGPNHGITHFDNFGFSMLTVYQCISMEGWTDVLYWVNDAIGNEWPWIYFVTL 317
Query: 3070 D-------------------SNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVI 3192
+ E +K + Q + +
Sbjct: 318 ILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLEEDLRGYMSWITQGEVMD 377
Query: 3193 VTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPR-NRL-QYRVWWFVTSRAFEYV 3366
V EG+ + D IE K R+ + NR+ +++ V S+ F ++
Sbjct: 378 VDDLREGKLSLDEGGSDTESLYEIEGLNKIIQFIRHWRQWNRVFRWKCHDLVKSKVFYWL 437
Query: 3367 IFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWN 3546
+ LI+ +NT+S+A +H+ DV N + +F E ++K+ L + Y +N
Sbjct: 438 VILIVALNTLSIASEHHNQPLWLTHLQDVANRVLLTLFTIEMLMKMYGLGLRQYFMSIFN 497
Query: 3547 VFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKS 3726
FD VV ++I + G + + I+ R R++RL K+ + L+ + + S
Sbjct: 498 RFDCFVVCSGILEILL--VESGAMSPLGISVLRCIRLLRLFKITKYWTSLSNLVASLLNS 555
Query: 3727 FQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGE 3906
+++ + LL+ L I+A++GMQ FG + T + R +NF +FP A++ +F+ TGE
Sbjct: 556 IRSIASLLLLLFLFIIIFALLGMQLFGGRYDFEDTEV-RRSNFDNFPQALISVFQVLTGE 614
Query: 3907 AWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP------YFISFFMLCSFLV 4068
W +M N YP YFI F+ ++++
Sbjct: 615 DWNSVM----------------------YNGIMAYGGPTYPGVLVCIYFIILFVCGNYIL 652
Query: 4069 INLFVAVIMDN 4101
+N+F+A+ +DN
Sbjct: 653 LNVFLAIAVDN 663
Score = 127 bits (318), Expect = 4e-27
Identities = 103/343 (30%), Positives = 159/343 (46%), Gaps = 12/343 (3%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+ RP L++ V N IR LC IV F IL I + AL
Sbjct: 757 RPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAAL 816
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P A +N +LE +YVF VFT+E VLK+ G H ++ RN +NILD +
Sbjct: 817 AAEDPIRADSM--RNQILEYFDYVFTAVFTVEIVLKMTTYGAFLHKGSFCRNYFNILDLL 874
Query: 496 IVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIA 675
+V + L+S L +I VK LR RVLRPLR ++ L+ V+ + A+ + +I
Sbjct: 875 VVAVSLISMGLESSAIS--VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIV 932
Query: 676 LLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLT 855
L+ + ++A IG++LF GK +S C D L++ C G + + D T
Sbjct: 933 LVTTLLQFMFACIGVQLFKGKFYS-CND-----LSKMTEEEC----RGYYYIYKDGDP-T 981
Query: 856 NMGVRWECSSNTTWPGPNNGITN---FDNFGLAMLTVFQCVSLEGWTDVMYWVNDA---- 1014
+ +R P I N FDN AM+++F + EGW ++Y D+
Sbjct: 982 QIELR-----------PRQWIHNDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNEED 1030
Query: 1015 -----VGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKERE 1128
R I+F+ +IL +FF++N+ +G + F ++ E
Sbjct: 1031 TGPVYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGE 1073
Score = 90.5 bits (223), Expect = 4e-16
Identities = 54/177 (30%), Positives = 99/177 (55%), Gaps = 4/177 (2%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP + +V FE+L+ +I N I L + Q Y S+ N + + + F ++F
Sbjct: 1105 NPYQYQVWYVVTSSYFEYLMFALIMLNTICLGM-QHY--NQSEQMNHISDILNVAFTIIF 1161
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKA----LR 570
T+E VLK++A F P AY + WN+ DF+IV+ ++ ILS++ + R
Sbjct: 1162 TLEMVLKLIA----FKPRAYFGDPWNVFDFLIVIGSIIDVILSEIDDPDESARISSAFFR 1217
Query: 571 AFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKL 741
FRV+R ++L++ ++ +L +++ L ++ALL++ + IYA+IG+++F GK+
Sbjct: 1218 LFRVMRLVKLLNRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMF-GKI 1273
Score = 60.5 bits (145), Expect = 5e-07
Identities = 42/167 (25%), Positives = 70/167 (41%), Gaps = 3/167 (1%)
Frame = +1
Query: 1477 EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEF 1656
+HY QSE ++H + N+ F I+F++EM+LK+ + Y +N FD +VI SI++
Sbjct: 1138 QHYNQSEQMNHISDILNVAFTIIFTLEMVLKLIAFKPRAYFGDPWNVFDFLIVIGSIIDV 1197
Query: 1657 VLVYFD---LMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXX 1827
+L D + + R R++R+ K+
Sbjct: 1198 ILSEIDDPDESARISSAFFRLFRVMRLVKLLNRAEGVRTLLWTFIKSFQALPYVALLIVM 1257
Query: 1828 XXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGE 1968
GMQ+FG + Q NF TF QA+L + + G+
Sbjct: 1258 LFFIYAVIGMQMFGKIAMVDGTQINRNNNFQTFPQAVLLLLGVPQGK 1304
Score = 40.8 bits (94), Expect = 0.38
Identities = 47/230 (20%), Positives = 87/230 (37%), Gaps = 38/230 (16%)
Frame = +1
Query: 1534 FVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSV 1701
F +F++E++LKM + G ++ + FN D VV S++ L + V +
Sbjct: 839 FTAVFTVEIVLKMTTYGAFLHKGSFCRNYFNILDLLVVAVSLISMGLESSAISV---VKI 895
Query: 1702 LRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF- 1878
LR R+LR + G+Q+F GKF
Sbjct: 896 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVLVTTLLQFMFACIGVQLFKGKFY 955
Query: 1879 ---------------------NFNPQQPKPRA--------NFDTFVQALLTVFQILTGED 1971
+ +P Q + R +FD + A++++F + T E
Sbjct: 956 SCNDLSKMTEEECRGYYYIYKDGDPTQIELRPRQWIHNDFHFDNVLSAMMSLFTVSTFEG 1015
Query: 1972 WNTVMYHGIES----FGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
W ++Y I+S G V V + I++I+ I + ++N+F+ +
Sbjct: 1016 WPQLLYKAIDSNEEDTGPVYNNRVEMAIFFIIYIILIAFFMMNIFVGFVI 1065
>gi|29378321|gb|AAO83842.1| voltage-dependent non-L-type calcium
channel alpha-1 subunit isoform b [Lymnaea stagnalis]
Length = 1609
Score = 676 bits (1743), Expect = 0.0
Identities = 350/736 (47%), Positives = 471/736 (63%), Gaps = 8/736 (1%)
Frame = +1
Query: 2308 KPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNM 2487
KP+ SS+FI TN R FC+ VVN YF ++ I SS LAAEDP+ NS RN
Sbjct: 865 KPMLPYSSMFIFGPTNPIRRFCHFVVNLRYFDLFIMIVICASSVALAAEDPVIENSRRNE 924
Query: 2488 ILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDA- 2664
ILNYFD+ FT VFT+E+ LKVI G++ H GS+ R+ +N+LD VV +L +FV A
Sbjct: 925 ILNYFDFVFTGVFTIELVLKVIDLGVLLHPGSYIRDLWNILDATVVICALVAFVFNDSAG 984
Query: 2665 --MSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGV 2838
++ INR LK V CV+ ++K + NI++V + QF+FA+I V
Sbjct: 985 KNLNTIKSLRVLRVLRPLKTINRVPKLKAVFDCVVNSLKNVSNILIVYILFQFIFAVIAV 1044
Query: 2839 QLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISL 3018
QLFKG FF C D SK T EC+G++ Y DG P + R W DF++DN+ AM++L
Sbjct: 1045 QLFKGRFFYCTDESKSTRDECQGQFFEY-DGHSNDPTVRDREWLRQDFHYDNIMMAMLTL 1103
Query: 3019 FVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIVT 3198
F V+T EGWP +L ++DS ED+GP R ++L +I+T
Sbjct: 1104 FTVTTGEGWPSVLKHSMDSTYEDRGPKPVYRMEMSLFYVVFFIVFPFFFVNIFVALIIIT 1163
Query: 3199 FQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRAFEYVIF 3372
FQ +GE E + E+DKNQ++CI+FA+ AKPH R+IP+N+ ++Y++W V S FEY +
Sbjct: 1164 FQEQGENELMDQEMDKNQKQCIDFAINAKPHCRFIPKNKNSIKYKIWRLVQSSKFEYFVM 1223
Query: 3373 LIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVF 3552
+I +NT+ L K+ S ++D L N FT +F E +LKI+ L P+NY D WNVF
Sbjct: 1224 TLITLNTIVLMMKYDGMSDNYKDVLAKLNEGFTVLFTLECLLKIIGLGPRNYFHDPWNVF 1283
Query: 3553 DLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQ 3732
D VVGS ID+ + + +S FFRLFR RLVKLL +G IR LLWTF +SF+
Sbjct: 1284 DFTTVVGSIIDVLITEFSK---RQVSFGFFRLFRAARLVKLLRQGYTIRLLLWTFFQSFK 1340
Query: 3733 ALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAW 3912
ALPYV LLI++LFFIYA+IGMQ FG + LD TSI+R+NNF +F +A+ +LFR ATGEAW
Sbjct: 1341 ALPYVCLLILMLFFIYAIIGMQVFGSIKLDSKTSINRHNNFRTFFSALTLLFRCATGEAW 1400
Query: 3913 QDIMLSCSDREDVRCDPMS-DDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAV 4089
Q IM SC + CDP S D + ES CG N AY YF+SF LCSFL++NLFVAV
Sbjct: 1401 QQIMQSCLAGQP--CDPESIRDDDPPDMAESGCGTNIAYMYFVSFIFLCSFLMLNLFVAV 1458
Query: 4090 IMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLC 4269
IMDNFDYLTRD SILGPHHL+E+VR+WS YDP A GRI + D+ +LR + PP+GFGK C
Sbjct: 1459 IMDNFDYLTRDSSILGPHHLDEYVRVWSMYDPKATGRIHYTDMYEMLRNMEPPVGFGKKC 1518
Query: 4270 PHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNL--KIYTEGNIDEANEQLRSAIKRI 4443
P++LA ++L+ MNMP+ DGTV F TLFAL+R L K+ +D +E++R I+++
Sbjct: 1519 PYKLAYRKLIRMNMPVAEDGTVHFTTTLFALIRECLIIKMGPAEIMDRRDEEMRETIRKL 1578
Query: 4444 WKRTHKDLLDEVVPPA 4491
W K ++D ++PP+
Sbjct: 1579 WPVQGKKMMDMLMPPS 1594
Score = 527 bits (1357), Expect = e-147
Identities = 301/686 (43%), Positives = 389/686 (55%), Gaps = 45/686 (6%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
N IRK I+EW PFE+++L I ANCI LA+ + P+QD L+ E F+ +F
Sbjct: 54 NFIRKYAKIIIEWGPFEYMVLLTIIANCIVLALEEHLPSQDKTPLALQLDDTEVYFLGIF 113
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRV 582
+E LKIVA+GF H +YLRN WNI+DFI+VV G + T+ ++ S FD++ LRA RV
Sbjct: 114 CVEAFLKIVALGFCLHKRSYLRNIWNIMDFIVVVTGFI-TLFAQGSSTTFDLRTLRAVRV 172
Query: 583 LRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI-- 756
LRPL+LVSG+PSLQVVL +I+RAM PLL + LLVLF I+I+AIIGLE + G H+ C
Sbjct: 173 LRPLKLVSGIPSLQVVLKSIIRAMAPLLQVCLLVLFAIVIFAIIGLEFYVGVFHNACYKK 232
Query: 757 --------DPATGQLAQKDPTPCGTDTEGS-AFKCQPSDSLTNMGVRWECSSNTTWPGPN 909
D TG + D PC +E AF+CQ + S G W GPN
Sbjct: 233 GSHTRSEDDIDTGD--EDDIRPCLPSSESQGAFQCQVNISNCKAG----------WRGPN 280
Query: 910 NGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLV 1089
GIT+FDN G AMLTVFQC+++EGWT+V+Y+ NDA+G ++ ++YF+ L+ILGSFF+LNLV
Sbjct: 281 AGITSFDNIGYAMLTVFQCITMEGWTNVLYYTNDALGNQFNFLYFIPLIILGSFFMLNLV 340
Query: 1090 LGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDI------------- 1230
LGVLSGEF+KERE+ R F K R +QQ+E +L GYL+WI +AE++
Sbjct: 341 LGVLSGEFAKERERVENRRAFFKLRRQQQIERELNGYLEWICKAEEVILSEERTTDEEKL 400
Query: 1231 --------------------EPVNEDEQED-EPVAQTXXXXXXXXXXXXXXXXXXPSKWA 1347
+ N+ EQ D + +A S W
Sbjct: 401 KIIEARRQAAARKMKQLKAEDNENDSEQNDNDLLAAMAPGNSFKSMKKRRTTGKCASFWR 460
Query: 1348 ARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMAN 1527
A + LVKSQ FYW SEHY Q EW F +
Sbjct: 461 AEKR--------FRYSIRRLVKSQLFYWIVIVLVFLNTASVASEHYNQPEWHVQFLYITE 512
Query: 1528 LFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLR 1707
F+ LF EM +KMY+LG Y S FN FDC V++ SI+E + F G+SVLR
Sbjct: 513 YAFLGLFIFEMSIKMYALGVRMYFQSSFNIFDCVVIVGSIVEVIWSEFKRGSSFGISVLR 572
Query: 1708 SARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFN 1887
+ RLLRIFKVT+YW+ GMQ+FGG+ NF
Sbjct: 573 ALRLLRIFKVTRYWSSLRNLVISLLSSMRSILSLLFLLFLFIIVFALLGMQLFGGEMNF- 631
Query: 1888 PQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFIC 2067
++ +P A+FDTF ALLTVFQILTGEDWN VMY+GI+S GG+ G+ Y+IVL +
Sbjct: 632 -EEGRPSAHFDTFPIALLTVFQILTGEDWNEVMYNGIKSHGGIENQGMFYSSYFIVLVLF 690
Query: 2068 GNYILLNVFLAIAVDNLADADSLTNA 2145
GNY LLNVFLAIAVDNLA+A LT A
Sbjct: 691 GNYTLLNVFLAIAVDNLANAQELTAA 716
Score = 174 bits (440), Expect = 3e-41
Identities = 151/663 (22%), Positives = 274/663 (40%), Gaps = 32/663 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR+ C +V + F+ I+ +ICA+ +ALA P ++ +N +L ++VF VF
Sbjct: 880 NPIRRFCHFVVNLRYFDLFIMIVICASSVALAAEDP--VIENSRRNEILNYFDFVFTGVF 937
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD-VKALRAFR 579
TIE VLK++ +G + HP +Y+R+ WNILD +V+ LV+ + + + + + +K+LR R
Sbjct: 938 TIELVLKVIDLGVLLHPGSYIRDLWNILDATVVICALVAFVFNDSAGKNLNTIKSLRVLR 997
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+ ++ VP L+ V + ++ ++ + +I ++ + I+A+I ++LF G+
Sbjct: 998 VLRPLKTINRVPKLKAVFDCVVNSLKNVSNILIVYILFQFIFAVIAVQLFKGRFFY---- 1053
Query: 760 PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNN-----GITN 924
C +++ + +CQ G +E ++ P + +
Sbjct: 1054 -------------CTDESKSTRDECQ--------GQFFEYDGHSNDPTVRDREWLRQDFH 1092
Query: 925 FDNFGLAMLTVFQCVSLEGWTDVMYWVNDA---------VGREWPWIYFVTLVILGSFFV 1077
+DN +AMLT+F + EGW V+ D+ V R +++V I+ FF
Sbjct: 1093 YDNIMMAMLTLFTVTTGEGWPSVLKHSMDSTYEDRGPKPVYRMEMSLFYVVFFIVFPFFF 1152
Query: 1078 LNLVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQE 1257
+N+ + ++ F ++ E Q+++++ K +D+ A+
Sbjct: 1153 VNIFVALIIITFQEQGENELM---------DQEMDKNQKQCIDFAINAK----------- 1192
Query: 1258 DEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXX 1437
+ + K LV+S F +
Sbjct: 1193 ------------------------------PHCRFIPKNKNSIKYKIWRLVQSSKFEYFV 1222
Query: 1438 XXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNR 1617
++ G S+ N F +LF++E LLK+ LG Y +N
Sbjct: 1223 MTLITLNTIVLMMKYDGMSDNYKDVLAKLNEGFTVLFTLECLLKIIGLGPRNYFHDPWNV 1282
Query: 1618 FDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXX 1797
FD V+ SI++ ++ F + + R R R+ K+ +
Sbjct: 1283 FDFTTVVGSIIDVLITEFS-KRQVSFGFFRLFRAARLVKLLRQGYTIRLLLWTFFQSFKA 1341
Query: 1798 XXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWN 1977
GMQVFG + NF TF AL +F+ TGE W
Sbjct: 1342 LPYVCLLILMLFFIYAIIGMQVFGSIKLDSKTSINRHNNFRTFFSALTLLFRCATGEAWQ 1401
Query: 1978 TVMYHGI-------ESF----------GGVGTLGVIVCIYYIVLFICGNYILLNVFLAIA 2106
+M + ES G GT I +Y++ ++++LN+F+A+
Sbjct: 1402 QIMQSCLAGQPCDPESIRDDDPPDMAESGCGT--NIAYMYFVSFIFLCSFLMLNLFVAVI 1459
Query: 2107 VDN 2115
+DN
Sbjct: 1460 MDN 1462
Score = 123 bits (309), Expect = 4e-26
Identities = 69/264 (26%), Positives = 137/264 (51%), Gaps = 1/264 (0%)
Frame = +1
Query: 3313 RLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEA 3492
R +Y + V S+ F +++ +++ +NT S+A +HY FL + F G+F FE
Sbjct: 464 RFRYSIRRLVKSQLFYWIVIVLVFLNTASVASEHYNQPEWHVQFLYITEYAFLGLFIFEM 523
Query: 3493 VLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVK 3672
+K+ AL + Y +N+FD +V+VGS +++ + + G + I+ R R++R+ K
Sbjct: 524 SIKMYALGVRMYFQSSFNIFDCVVIVGSIVEVIWSEFKRGSS--FGISVLRALRLLRIFK 581
Query: 3673 LLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNN 3849
+ +R L+ + + S +++ + L+ L ++A++GMQ F G++ ++ +
Sbjct: 582 VTRYWSSLRNLVISLLSSMRSILSLLFLLFLFIIVFALLGMQLFGGEMNFEEG---RPSA 638
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
+F +FP A+L +F+ TGE W ++M + H G N+ F
Sbjct: 639 HFDTFPIALLTVFQILTGEDWNEVMYN------------GIKSHGGIENQGM----FYSS 682
Query: 4030 YFISFFMLCSFLVINLFVAVIMDN 4101
YFI + ++ ++N+F+A+ +DN
Sbjct: 683 YFIVLVLFGNYTLLNVFLAIAVDN 706
Score = 93.2 bits (230), Expect = 6e-17
Identities = 70/270 (25%), Positives = 117/270 (42%), Gaps = 21/270 (7%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMILNYFD- 2505
SLFI S N R + +++ F VL I+ + +LA E+ L + + L D
Sbjct: 46 SLFIFSEENFIRKYAKIIIEWGPFEYMVLLTIIANCIVLALEEHLPSQDKTPLALQLDDT 105
Query: 2506 -YFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVS-LTSFVLRTDAMSXXX 2679
+F +F VE LK++ G HK S+ RN +N++D +VV +T F +
Sbjct: 106 EVYFLGIFCVEAFLKIVALGFCLHKRSYLRNIWNIMDFIVVVTGFITLFAQGSSTTFDLR 165
Query: 2680 XXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTF 2859
++ L+ V++ +I A+ + + L+ +FAIIG++ + G F
Sbjct: 166 TLRAVRVLRPLKLVSGIPSLQVVLKSIIRAMAPLLQVCLLVLFAIVIFAIIGLEFYVGVF 225
Query: 2860 F-LCNDLSKMTEAECRGEYIHYEDGDPTKPVSK--------------KRVWSNND---FN 2985
C T +E + +D P P S+ K W + +
Sbjct: 226 HNACYKKGSHTRSEDDIDTGDEDDIRPCLPSSESQGAFQCQVNISNCKAGWRGPNAGITS 285
Query: 2986 FDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
FDN+G AM+++F T EGW +LY D+
Sbjct: 286 FDNIGYAMLTVFQCITMEGWTNVLYYTNDA 315
Score = 86.3 bits (212), Expect = 8e-15
Identities = 75/305 (24%), Positives = 129/305 (41%), Gaps = 55/305 (18%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACKHYPSSRGFEDF---LDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY++ L I+ N + LA + + S+ LD + F G+F EA LKIVAL
Sbjct: 69 FEYMVLLTIIANCIVLALEEHLPSQDKTPLALQLDDTEVYFLGIFCVEAFLKIVALGFCL 128
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ ++Y+ + WN+ D +VVV FI + G + + R RV+R +KL+S
Sbjct: 129 HKRSYLRNIWNIMDFIVVVTGFITL----FAQGSSTTFDLRTLRAVRVLRPLKLVSGIPS 184
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKV-------------------- 3813
++ +L + +++ L V LL++ I+A+IG++F+ V
Sbjct: 185 LQVVLKSIIRAMAPLLQVCLLVLFAIVIFAIIGLEFYVGVFHNACYKKGSHTRSEDDIDT 244
Query: 3814 --------ALDDSTS-------IHRNN-------------NFHSFPAAILVLFRSATGEA 3909
L S S ++ +N +F + A+L +F+ T E
Sbjct: 245 GDEDDIRPCLPSSESQGAFQCQVNISNCKAGWRGPNAGITSFDNIGYAMLTVFQCITMEG 304
Query: 3910 WQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAV 4089
W +++ +D GN F + YFI +L SF ++NL + V
Sbjct: 305 WTNVLYYTND---------------------ALGNQFNFLYFIPLIILGSFFMLNLVLGV 343
Query: 4090 IMDNF 4104
+ F
Sbjct: 344 LSGEF 348
Score = 83.2 bits (204), Expect = 7e-14
Identities = 74/319 (23%), Positives = 145/319 (45%), Gaps = 6/319 (1%)
Frame = +1
Query: 250 IVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIV 429
+V+ + F ++++ ++ N ++A ++ L EY F+ +F E +K+
Sbjct: 472 LVKSQLFYWIVIVLVFLNTASVASEH---YNQPEWHVQFLYITEYAFLGLFIFEMSIKMY 528
Query: 430 AMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSI-QGFDVKALRAFRVLRPLRLVS 606
A+G Y ++++NI D +++V +V I S+ F + LRA R+LR ++
Sbjct: 529 ALGVRM----YFQSSFNIFDCVVIVGSIVEVIWSEFKRGSSFGISVLRALRLLRIFKVTR 584
Query: 607 GVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQK 786
SL+ ++ ++L +M +L + L+ I+++A++G++LF G+++
Sbjct: 585 YWSSLRNLVISLLSSMRSILSLLFLLFLFIIVFALLGMQLFGGEMNFE------------ 632
Query: 787 DPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQC 966
EG +PS +FD F +A+LTVFQ
Sbjct: 633 ---------EG-----RPS-------------------------AHFDTFPIALLTVFQI 653
Query: 967 VSLEGWTDVMY-WVNDAVGREWPWI----YFVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
++ E W +VMY + G E + YF+ LV+ G++ +LN+ L + + +E
Sbjct: 654 LTGEDWNEVMYNGIKSHGGIENQGMFYSSYFIVLVLFGNYTLLNVFLAIAVDNLANAQEL 713
Query: 1132 ARARGLFQKFREKQQLEED 1188
A E++Q EE+
Sbjct: 714 TAA--------EEEQEEEE 724
Score = 51.6 bits (122), Expect = 2e-04
Identities = 48/255 (18%), Positives = 111/255 (42%), Gaps = 5/255 (1%)
Frame = +1
Query: 2359 FRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEI 2538
FR +V F V+ + +++A +A+E Q L +Y F +F E+
Sbjct: 465 FRYSIRRLVKSQLFYWIVIVLVFLNTASVASEHYNQPE-WHVQFLYITEYAFLGLFIFEM 523
Query: 2539 TLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFV---LRTDAMSXXXXXXXXXXXXX 2709
++K+ G+ + +++FN+ D +V+ S+ + + +
Sbjct: 524 SIKMYALGVRM----YFQSSFNIFDCVVIVGSIVEVIWSEFKRGSSFGISVLRALRLLRI 579
Query: 2710 XXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMT 2889
L+++V ++ ++++I +++ + F+ +FA++G+QLF G
Sbjct: 580 FKVTRYWSSLRNLVISLLSSMRSILSLLFLLFLFIIVFALLGMQLFGGE----------- 628
Query: 2890 EAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAI 3069
+++E+G P+ +FD A++++F + T E W +++Y I
Sbjct: 629 --------MNFEEGRPSA-------------HFDTFPIALLTVFQILTGEDWNEVMYNGI 667
Query: 3070 DSNE--EDKGPIHNS 3108
S+ E++G ++S
Sbjct: 668 KSHGGIENQGMFYSS 682
>gi|6680820|ref|NP_031604.1| calcium channel, voltage-dependent, P/Q
type, alpha 1A subunit; calcium channel, P/Q type, alpha
1A [Mus musculus]
gi|5921454|sp|P97445|CCAA_MOUSE Voltage-dependent P/Q-type calcium
channel alpha-1A subunit (Voltage-gated calcium channel
alpha subunit Cav2.1) (Calcium channel, L type, alpha-1
polypeptide isoform 4) (Brain calcium channel I) (BI)
gi|1710177|gb|AAC52940.1| voltage-sensitive calcium channel alpha 1 A
[Mus musculus]
Length = 2164
Score = 675 bits (1742), Expect = 0.0
Identities = 355/779 (45%), Positives = 494/779 (62%), Gaps = 17/779 (2%)
Frame = +1
Query: 2290 PAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQA 2469
P KP+P SS+FILS TN R C+ ++N YF +L I +SS LAAEDP+Q
Sbjct: 1113 PGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQP 1172
Query: 2470 NSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFV 2649
N+ RN +L YFDY FT VFT E+ +K+I GLV H+G++ R+ +N+LD +VV+ +L +F
Sbjct: 1173 NAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFA 1232
Query: 2650 LRTDA----MSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQF 2817
++ ++ I R LK V CV+ ++K + NI++V + F
Sbjct: 1233 FTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMF 1292
Query: 2818 MFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNV 2997
+FA++ VQ FKG FF C D SK E +CRG+Y YE + ++ R W +F++DNV
Sbjct: 1293 IFAVVAVQFFKGKFFHCTDESKEFERDCRGKYFLYEKNEVK---ARDREWKKYEFHYDNV 1349
Query: 2998 GDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXX 3177
A+++LF VST EGWPQ+L ++D+ E++GP R +++
Sbjct: 1350 LWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIF 1409
Query: 3178 XGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSR 3351
+I+TFQ +G++ E L+KN+R CI+FA+ AKP R++P+N+ QYR+W FV S
Sbjct: 1410 VALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSP 1469
Query: 3352 AFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYI 3531
FEY I +I +NT+ L K Y +S +E+ L VFN++FT +F+ E VLK++A NY
Sbjct: 1470 PFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYF 1529
Query: 3532 SDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLW 3711
D WN+FD + V+GS DI + G N I+++F RLFR RL+KLL +G IR LLW
Sbjct: 1530 RDAWNIFDFVTVLGSITDILVTEF---GNNFINLSFLRLFRAARLIKLLRQGYTIRILLW 1586
Query: 3712 TFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALD--------DSTSIHRNNNFHSFP 3867
TF++SF+ALPYV LLI +LFFIYA+IGMQ FG + +D D I +NNF +F
Sbjct: 1587 TFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDGEDEDSDEDEFQITEHNNFRTFF 1646
Query: 3868 AAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFF 4047
A+++LFRSATGEAW +IMLSC + CD S G+ + CGN FAY YF+SF
Sbjct: 1647 QALMLLFRSATGEAWHNIMLSCLSGKP--CDKNS------GILTADCGNEFAYFYFVSFI 1698
Query: 4048 MLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTL 4227
LCSFL++NLFVAVIMDNF+YLTRD SILGPHHL+E+VR+W+EYDP A GRI + D+ +L
Sbjct: 1699 FLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAACGRIHYKDMYSL 1758
Query: 4228 LRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKI-YTEGNID 4404
LR ISPPLG GK CPHR+ACKRL+ M++P+ D TV FN+TL AL+RT L I +G D
Sbjct: 1759 LRVISPPLGLGKKCPHRVACKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGAD 1818
Query: 4405 --EANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRK 4575
+ + +LR + IW + LD +V P K D+TVGK YA +I +Y+R+ K +K
Sbjct: 1819 KQQMDAELRKEMMAIWPNLSQKTLDLLVTP-HKSTDLTVGKIYAAMMIMEYYRQSKAKK 1876
Score = 536 bits (1380), Expect = e-150
Identities = 296/667 (44%), Positives = 383/667 (57%), Gaps = 27/667 (4%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N +RK I EW PFE++IL I ANCI LA+ Q P D + L+ E FI +
Sbjct: 38 DNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGI 97
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KIVA+GF FH +YLRN WN++DF++V+ G+++T+ ++ FD++ LRA R
Sbjct: 98 FCFEAGIKIVALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE-----FDLRTLRAVR 152
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQVVL +I++AMIPLL I LL+ F ILI+AIIGLE + GK H+TC +
Sbjct: 153 VLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFE 212
Query: 760 PATGQLAQKDPTPCGTD----TEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNF 927
T + + P PCGT+ T + KCQP W GPNNGIT F
Sbjct: 213 EGTDDIQGESPAPCGTEEPARTCPNGTKCQPY-----------------WEGPNNGITQF 255
Query: 928 DNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSG 1107
DN A+LTVFQC+++EGWTD++Y NDA G W W+YF+ L+I+GSFF+LNLVLGVLSG
Sbjct: 256 DNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSG 315
Query: 1108 EFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVAQTXXX 1287
EF+KERE+ R F K R +QQ+E +L GY++WI++AE++ + EDE + E
Sbjct: 316 EFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEV-ILAEDETDVEQRHPFDGA 374
Query: 1288 XXXXXXXXXXXXXXXP-----------------SKWAARMKRLE------KLNXXXXXXX 1398
P ++ + + +LE K
Sbjct: 375 LRRATLKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFYI 434
Query: 1399 XXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYS 1578
+VK+Q FYW HY Q EWL F A F+ LF EM +KMY
Sbjct: 435 RRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYG 494
Query: 1579 LGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXX 1758
LG Y S FN FDC V+I SI E + G+SVLR+ RLLRIFKVTKYW
Sbjct: 495 LGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASL 554
Query: 1759 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQAL 1938
GMQ+FGG+FNF+ + P NFDTF A+
Sbjct: 555 RNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFD--EGTPPTNFDTFPAAI 612
Query: 1939 LTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNL 2118
+TVFQILTGEDWN VMY GI+S GGV G++ IY+IVL + GNY LLNVFLAIAVDNL
Sbjct: 613 MTVFQILTGEDWNEVMYDGIKSQGGVQG-GMVFSIYFIVLTLFGNYTLLNVFLAIAVDNL 671
Query: 2119 ADADSLT 2139
A+A LT
Sbjct: 672 ANAQELT 678
Score = 168 bits (426), Expect = 1e-39
Identities = 157/660 (23%), Positives = 275/660 (40%), Gaps = 29/660 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+R+LC I+ + FE IL +I + IALA P Q + +N +L +YVF VF
Sbjct: 1134 NPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDP--VQPNAPRNNVLRYFDYVFTGVF 1191
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD---VKALRA 573
T E V+K++ +G + H AY R+ WNILDFI+V LV+ + S +G D +K+LR
Sbjct: 1192 TFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNS-KGKDINTIKSLRV 1250
Query: 574 FRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTC 753
RVLRPL+ + +P L+ V + ++ ++ + +I ++ + + I+A++ ++ F GK C
Sbjct: 1251 LRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQFFKGKFFH-C 1309
Query: 754 IDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDN 933
D + D G F + ++ + + W ++DN
Sbjct: 1310 TD---------ESKEFERDCRGKYFLYEKNEVK---------ARDREW---KKYEFHYDN 1348
Query: 934 FGLAMLTVFQCVSLEGWTDVMYWVNDAV---------GREWPWIYFVTLVILGSFFVLNL 1086
A+LT+F + EGW V+ DA R I++V ++ FF +N+
Sbjct: 1349 VLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNI 1408
Query: 1087 VLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEP 1266
+ ++ F ++ + K E+ LE++ + +D+ A+ +
Sbjct: 1409 FVALIIITFQEQGD---------KMMEEYSLEKNERACIDFAISAKPL------------ 1447
Query: 1267 VAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXX 1446
+ + + V S F +
Sbjct: 1448 -----------------------------TRHMPQNKQSFQYRMWQFVVSPPFEYTIMAM 1478
Query: 1447 XXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDC 1626
+ YG S ++ + N+ F LFS+E +LK+ + G Y +N FD
Sbjct: 1479 IALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDF 1538
Query: 1627 FVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXX 1806
V+ SI + ++ F + +S LR R R+ K+ +
Sbjct: 1539 VTVLGSITDILVTEFG-NNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPY 1597
Query: 1807 XXXXXXXXXXXXXXXGMQVFGG--------KFNFNPQQPKPRANFDTFVQALLTVFQILT 1962
GMQVFG + + Q NF TF QAL+ +F+ T
Sbjct: 1598 VCLLIAMLFFIYAIIGMQVFGNIGIDGEDEDSDEDEFQITEHNNFRTFFQALMLLFRSAT 1657
Query: 1963 GEDWNTVMYHGI-----ESFGGVGT--LGVIVCIYYIV--LFICGNYILLNVFLAIAVDN 2115
GE W+ +M + + G+ T G +Y V +F+C ++++LN+F+A+ +DN
Sbjct: 1658 GEAWHNIMLSCLSGKPCDKNSGILTADCGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1716
Score = 120 bits (300), Expect = 5e-25
Identities = 73/274 (26%), Positives = 139/274 (50%), Gaps = 4/274 (1%)
Frame = +1
Query: 3313 RLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEA 3492
R+++ + V ++AF + + ++ +NT+ +A HY DFL IF G+F E
Sbjct: 429 RMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEM 488
Query: 3493 VLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVK 3672
+K+ L + Y +N FD V++GS ++ + + PG + I+ R R++R+ K
Sbjct: 489 FIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTS--FGISVLRALRLLRIFK 546
Query: 3673 LLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNN 3849
+ +R L+ + + S +++ + L+ L ++A++GMQ F G+ D+ T
Sbjct: 547 VTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTP---PT 603
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FPAAI+ +F+ TGE W ++M + ++ +GG+ G
Sbjct: 604 NFDTFPAAIMTVFQILTGEDWNEVMY-----DGIK--------SQGGVQ----GGMVFSI 646
Query: 4030 YFISFFMLCSFLVINLFVAVIMDNF---DYLTRD 4122
YFI + ++ ++N+F+A+ +DN LT+D
Sbjct: 647 YFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 680
Score = 95.9 bits (237), Expect = 1e-17
Identities = 73/296 (24%), Positives = 130/296 (43%), Gaps = 13/296 (4%)
Frame = +1
Query: 265 PFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFM 444
PFE+ I+ MI N I L + + Y+N L VF +F++ECVLK++A G +
Sbjct: 1470 PFEYTIMAMIALNTIVLMM--KFYGASVAYENAL-RVFNIVFTSLFSLECVLKVMAFGIL 1526
Query: 445 FHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQ 624
Y R+AWNI DF+ V+ + ++++ ++ LR FR R ++L+ +++
Sbjct: 1527 ----NYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIR 1582
Query: 625 VVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCG 804
++L +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1583 ILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF------------------------- 1617
Query: 805 TDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGW 984
N+G+ E + NF F A++ +F+ + E W
Sbjct: 1618 ----------------GNIGIDGEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAW 1661
Query: 985 TDVMYWV--------NDAV-----GREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
++M N + G E+ + YFV+ + L SF +LNL + V+ F
Sbjct: 1662 HNIMLSCLSGKPCDKNSGILTADCGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1717
Score = 84.0 bits (206), Expect = 4e-14
Identities = 68/262 (25%), Positives = 115/262 (42%), Gaps = 13/262 (4%)
Frame = +1
Query: 2332 LFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYFD 2505
LF S N R + + F +L I+ + +LA E L + M L+ +
Sbjct: 32 LFFFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTE 91
Query: 2506 YFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSL-----TSFVLRTDAMS 2670
+F +F E +K++ G FHKGS+ RN +N++D +VV + T F LRT
Sbjct: 92 PYFIGIFCFEAGIKIVALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRT---- 147
Query: 2671 XXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFK 2850
++ L+ V++ ++ A+ + I L+ F +FAIIG++ +
Sbjct: 148 ----LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYM 203
Query: 2851 GTFFL------CNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMI 3012
G F +D+ + A C E + TK +N FDN+ A++
Sbjct: 204 GKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVL 263
Query: 3013 SLFVVSTFEGWPQLLYVAIDSN 3078
++F T EGW LLY + D++
Sbjct: 264 TVFQCITMEGWTDLLYNSNDAS 285
Score = 81.3 bits (199), Expect = 3e-13
Identities = 76/293 (25%), Positives = 123/293 (41%), Gaps = 43/293 (14%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY+I I+ N + LA + H P + LD F G+F FEA +KIVAL
Sbjct: 54 FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIVALGFAF 113
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WNV D +VV+ G L GT + R RV+R +KL+S
Sbjct: 114 HKGSYLRNGWNVMDFVVVL-------TGILATVGTE-FDLRTLRAVRVLRPLKLVSGIPS 165
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQF----FGKVALDDSTSIHR------ 3843
++ +L + MK+ L + LL+ I+A+IG++F F ++ T +
Sbjct: 166 LQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAP 225
Query: 3844 -----------------------NN---NFHSFPAAILVLFRSATGEAWQDIMLSCSDRE 3945
NN F + A+L +F+ T E W D++ + +D
Sbjct: 226 CGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDAS 285
Query: 3946 DVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
GN + + YFI ++ SF ++NL + V+ F
Sbjct: 286 ---------------------GNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 317
Score = 75.9 bits (185), Expect = 1e-11
Identities = 72/322 (22%), Positives = 140/322 (43%), Gaps = 16/322 (4%)
Frame = +1
Query: 250 IVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIV 429
+V+ + F + +L ++ N + +AI ++ + L E++F+ +F E +K+
Sbjct: 437 MVKTQAFYWTVLSLVALNTLCVAIVH---YNQPEWLSDFLYYAEFIFLGLFMSEMFIKMY 493
Query: 430 AMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKALRAFRVLRPLRLV 603
+G Y +++N D V+IG + ++ + G F + LRA R+LR ++
Sbjct: 494 GLG----TRPYFHSSFNCFD-CGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVT 548
Query: 604 SGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ 783
SL+ ++ ++L +M ++ + L+ I+++A++G++LF GQ
Sbjct: 549 KYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLF------------GGQFNF 596
Query: 784 KDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQ 963
+ TP TNFD F A++TVFQ
Sbjct: 597 DEGTPP---------------------------------------TNFDTFPAAIMTVFQ 617
Query: 964 CVSLEGWTDVMY-WVNDAVGREWPW---IYFVTLVILGSFFVLNLVLGV----------L 1101
++ E W +VMY + G + IYF+ L + G++ +LN+ L + L
Sbjct: 618 ILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQEL 677
Query: 1102 SGEFSKEREKARARGLFQKFRE 1167
+ + +E E A + QK +E
Sbjct: 678 TKDEQEEEEAANQKLALQKAKE 699
Score = 46.2 bits (108), Expect = 0.009
Identities = 50/264 (18%), Positives = 103/264 (38%), Gaps = 3/264 (1%)
Frame = +1
Query: 2293 AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN 2472
A +++K +S F R + +V F VL + +++ +A Q
Sbjct: 408 ARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPE 467
Query: 2473 STRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL 2652
+ L Y ++ F +F E+ +K+ G + ++FN D V+ S+ +
Sbjct: 468 WLSDF-LYYAEFIFLGLFMSEMFIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIW 522
Query: 2653 RTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
K L+++V ++ ++K+I +++ + F+ +F
Sbjct: 523 AVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 582
Query: 2824 AIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGD 3003
A++G+QLF G F ++++G P NFD
Sbjct: 583 ALLGMQLFGGQF-------------------NFDEGTPPT-------------NFDTFPA 610
Query: 3004 AMISLFVVSTFEGWPQLLYVAIDS 3075
A++++F + T E W +++Y I S
Sbjct: 611 AIMTVFQILTGEDWNEVMYDGIKS 634
>gi|7159258|gb|AAF37688.1| calcium channel alpha1E subunit, delta19
delta40 delta46 splice variant [Homo sapiens]
Length = 2162
Score = 672 bits (1733), Expect = 0.0
Identities = 357/774 (46%), Positives = 487/774 (62%), Gaps = 13/774 (1%)
Frame = +1
Query: 2302 TVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR 2481
T K + SS+FI S TN R C+ +VN YF +L I SS LAAEDP+ NS R
Sbjct: 1015 TGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSER 1074
Query: 2482 NMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTD 2661
N +L YFDY FT VFT E+ +K+I GL+ GS+ R+ +N+LD +VV +L +F L
Sbjct: 1075 NKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANA 1134
Query: 2662 A-------MSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFM 2820
+ I R LK V CV+ ++K + NI++V + F+
Sbjct: 1135 LGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFI 1194
Query: 2821 FAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVG 3000
FA+I VQLFKG FF C D SK TE EC G Y+ +E K K R W ++F++DN+
Sbjct: 1195 FAVIAVQLFKGKFFYCTDSSKDTEKECIGNYVDHEKN---KMEVKGREWKRHEFHYDNII 1251
Query: 3001 DAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXX 3180
A+++LF VST EGWPQ+L ++D EED+GP ++R +++
Sbjct: 1252 WALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFV 1311
Query: 3181 GFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRA 3354
+I+TFQ +G++ E C L+KN+R CI+FA+ AKP RY+P+NR QYRVW FV S +
Sbjct: 1312 ALIIITFQEQGDKMMEECSLEKNERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPS 1371
Query: 3355 FEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYIS 3534
FEY I +I +NTV L K+Y + +E L N+ FT VF+ E VLK++A NY
Sbjct: 1372 FEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFR 1431
Query: 3535 DRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWT 3714
D WN+FD + V+GS +I T+ +++F +LFR RL+KLL +G IR LLWT
Sbjct: 1432 DTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWT 1491
Query: 3715 FMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRS 3894
F++SF+ALPYV LLI +LFFIYA+IGMQ FG + LD+ + I+R+NNF SF ++++LFRS
Sbjct: 1492 FVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRS 1551
Query: 3895 ATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNES-RCGNNFAYPYFISFFMLCSFLVI 4071
ATGEAWQ+IMLSC + C+P D G NE+ RCG + AY YF+SF CSFL++
Sbjct: 1552 ATGEAWQEIMLSCLGEKG--CEP--DTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLML 1607
Query: 4072 NLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPL 4251
NLFVAVIMDNF+YLTRD SILGPHHL+EFVR+W+EYD A GRI + D+ L+R ISPPL
Sbjct: 1608 NLFVAVIMDNFEYLTRDSSILGPHHLDEFVRVWAEYDRAACGRIPYKDMYKLVRVISPPL 1667
Query: 4252 GFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKI-YTEGNID--EANEQL 4422
G G+ CP+R+ACKRLV MNMP+ D TV F +TL AL+RT L I +G D + + +L
Sbjct: 1668 GLGENCPYRVACKRLVLMNMPVAEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSEL 1727
Query: 4423 RSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEME 4584
+ IW + +LD +V P K D+TVGK YA +I DY+++ K +K+ +
Sbjct: 1728 QKETLAIWPHLSQKMLDLLV-PMPKASDLTVGKIYAAMMIMDYYKQSKVKKQRQ 1780
Score = 502 bits (1293), Expect = e-140
Identities = 282/652 (43%), Positives = 364/652 (55%), Gaps = 27/652 (4%)
Frame = +1
Query: 265 PFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFM 444
PFE++IL I ANCI LA+ Q P D + LE E FI +F E +KIVA+GF+
Sbjct: 1 PFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFI 60
Query: 445 FHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQ 624
FH +YLRN WN++DFI+V+ G+++T + + D++ LRA RVLRPL+LVSG+PSLQ
Sbjct: 61 FHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTH-VDLRTLRAVRVLRPLKLVSGIPSLQ 119
Query: 625 VVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPT-PC 801
+VL +I++AM+PLL I LL+ F IL++AIIGLE + GKLH C +G L DP PC
Sbjct: 120 IVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPC 179
Query: 802 GTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEG 981
G + ++C+ W GPN+GIT FDN A+LTVFQC+++EG
Sbjct: 180 GVQGCPAGYECKD------------------WIGPNDGITQFDNILFAVLTVFQCITMEG 221
Query: 982 WTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKF 1161
WT V+Y NDA+G W W+YF+ L+I+GSFFVLNLVLGVLSGEF+KERE+ R F K
Sbjct: 222 WTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMKL 281
Query: 1162 REKQQLEEDLKGYLDWITQAEDIEPVNED--------------------------EQEDE 1263
R +QQ+E +L GY WI +AE++ E+ + DE
Sbjct: 282 RRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEAMTRDSSDE 341
Query: 1264 PVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXX 1443
+ +RL +++ +VKSQ FYW
Sbjct: 342 HCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRIS------IRHMVKSQVFYWIVLS 395
Query: 1444 XXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFD 1623
H+ Q +WL H A F+ LF +EM LKMY +G Y S FN FD
Sbjct: 396 LVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFD 455
Query: 1624 CFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXX 1803
V + SI E V F G+SVLR+ RLLRIFK+TKYW
Sbjct: 456 FGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSII 515
Query: 1804 XXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTV 1983
GMQ+FGG+FNFN P ANFDTF A++TVFQILTGEDWN V
Sbjct: 516 SLLFLLFLFIVVFALLGMQLFGGRFNFN--DGTPSANFDTFPAAIMTVFQILTGEDWNEV 573
Query: 1984 MYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLT 2139
MY+GI S GGV + G+ IY+IVL + GNY LLNVFLAIAVDNLA+A LT
Sbjct: 574 MYNGIRSQGGVSS-GMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELT 624
Score = 130 bits (327), Expect = 4e-28
Identities = 101/378 (26%), Positives = 172/378 (44%), Gaps = 14/378 (3%)
Frame = +1
Query: 139 KRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIALA 318
++ Q+K R+T NPIR+ C IV + FE IL +I A+ IALA
Sbjct: 1004 EKKKQKKEKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALA 1063
Query: 319 IYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFII 498
P +N +L +YVF VFT E V+K++ G + +Y R+ WNILDF++
Sbjct: 1064 AEDPVLTNSE--RNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVV 1121
Query: 499 VVIGLVSTILSKM--SIQGFD---VKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPL 663
VV LV+ L+ + +G D +K+LR RVLRPL+ + +P L+ V + ++ ++ +
Sbjct: 1122 VVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNV 1181
Query: 664 LHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPS 843
+I ++ + I+A+I ++LF GK C D + DTE
Sbjct: 1182 FNILIVYKLFMFIFAVIAVQLFKGKFF-YCTDSS-------------KDTEKECIGNYVD 1227
Query: 844 DSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAV-- 1017
M V+ W ++DN A+LT+F + EGW V+ D
Sbjct: 1228 HEKNKMEVK-----GREW---KRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEE 1279
Query: 1018 -------GREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQQ 1176
R I++V ++ FF +N+ + ++ F ++ + K E+
Sbjct: 1280 DRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGD---------KMMEECS 1330
Query: 1177 LEEDLKGYLDWITQAEDI 1230
LE++ + +D+ A+ +
Sbjct: 1331 LEKNERACIDFAISAKPL 1348
Score = 115 bits (289), Expect = 9e-24
Identities = 72/273 (26%), Positives = 137/273 (49%), Gaps = 4/273 (1%)
Frame = +1
Query: 3316 LQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAV 3495
L+ + V S+ F +++ ++ +NT +A H+ + L +F G+F E
Sbjct: 376 LRISIRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMS 435
Query: 3496 LKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKL 3675
LK+ + P+ Y +N FD V VGS ++ + PG + I+ R R++R+ K+
Sbjct: 436 LKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTS--FGISVLRALRLLRIFKI 493
Query: 3676 LSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNN 3852
+R L+ + M S +++ + L+ L ++A++GMQ F G+ +D T + N
Sbjct: 494 TKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTP---SAN 550
Query: 3853 FHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPY 4032
F +FPAAI+ +F+ TGE W ++M + +R +GG++ ++ Y
Sbjct: 551 FDTFPAAIMTVFQILTGEDWNEVMYN-----GIR--------SQGGVSSGM----WSAIY 593
Query: 4033 FISFFMLCSFLVINLFVAVIMDNF---DYLTRD 4122
FI + ++ ++N+F+A+ +DN LT+D
Sbjct: 594 FIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 626
Score = 90.1 bits (222), Expect = 6e-16
Identities = 75/303 (24%), Positives = 133/303 (43%), Gaps = 21/303 (6%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+ I+ MI N + L + Y + Y+ L+ + F +VF++ECVLK++A GF+
Sbjct: 1372 FEYTIMAMIALNTVVLMM--KYYSAPCTYE-LALKYLNIAFTMVFSLECVLKVIAFGFL- 1427
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMSI---QGFDVKALRAFRVLRPLRLVSGVPS 618
Y R+ WNI DFI V+ + IL+ + GF++ L+ FR R ++L+ +
Sbjct: 1428 ---NYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYT 1484
Query: 619 LQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTP 798
++++L +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1485 IRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF----------------------- 1521
Query: 799 CGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLE 978
N+ + E N +N +F FG ML +F+ + E
Sbjct: 1522 ------------------GNIKLDEESHINR-----HNNFRSF--FGSLML-LFRSATGE 1555
Query: 979 GWTDVMYWV------------------NDAVGREWPWIYFVTLVILGSFFVLNLVLGVLS 1104
W ++M N+ G + ++YFV+ + SF +LNL + V+
Sbjct: 1556 AWQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIM 1615
Query: 1105 GEF 1113
F
Sbjct: 1616 DNF 1618
Score = 86.3 bits (212), Expect = 8e-15
Identities = 80/346 (23%), Positives = 152/346 (43%), Gaps = 9/346 (2%)
Frame = +1
Query: 232 RKLCISI---VEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
R L ISI V+ + F +++L ++ N +AI Q + LL E++F+ +F
Sbjct: 374 RLLRISIRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQ---WLTHLLYYAEFLFLGLF 430
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKALRAF 576
+E LK+ MG P Y +++N DF + V G + ++ + G F + LRA
Sbjct: 431 LLEMSLKMYGMG----PRLYFHSSFNCFDFGVTV-GSIFEVVWAIFRPGTSFGISVLRAL 485
Query: 577 RVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI 756
R+LR ++ SL+ ++ +++ +M ++ + L+ I+++A++G++LF G+ +
Sbjct: 486 RLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFN-- 543
Query: 757 DPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNF 936
D TP NFD F
Sbjct: 544 ----------DGTPSA---------------------------------------NFDTF 554
Query: 937 GLAMLTVFQCVSLEGWTDVMYWVNDAVG----REWPWIYFVTLVILGSFFVLNLVLGVLS 1104
A++TVFQ ++ E W +VMY + G W IYF+ L + G++ +LN+ L +
Sbjct: 555 PAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAIYFIVLTLFGNYTLLNVFLAIAV 614
Query: 1105 GEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVN 1242
+ Q+ + +Q EE+ + +A+++ P++
Sbjct: 615 DNLANA----------QELTKDEQEEEEAFNQKHALQKAKEVSPMS 650
Score = 79.0 bits (193), Expect = 1e-12
Identities = 104/484 (21%), Positives = 184/484 (37%), Gaps = 46/484 (9%)
Frame = +1
Query: 1534 FVILFSMEMLLKMYSLGFTTYTTSQF----NRFDCFVVISSILEFVLVY-FDLMKPLGVS 1698
F +F+ EM++KM G S F N D VV+ +++ F L K +
Sbjct: 1085 FTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIK 1144
Query: 1699 VLRSARLLRIF---KVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFG 1869
++S R+LR+ K K +Q+F
Sbjct: 1145 TIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFK 1204
Query: 1870 GKFNF---------------------NPQQPKPRA------NFDTFVQALLTVFQILTGE 1968
GKF + N + K R ++D + ALLT+F + TGE
Sbjct: 1205 GKFFYCTDSSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGE 1264
Query: 1969 DWNTVMYHGI----ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLAD-ADS 2133
W V+ H + E G + + + I+Y+V F+ + +N+F+A+ + + D
Sbjct: 1265 GWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDK 1324
Query: 2134 LTNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSARPRRMSEVPAASTVKP 2313
+ S + + A + KP
Sbjct: 1325 MMEE-------------------------------------CSLEKNERACIDFAISAKP 1347
Query: 2314 IPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMIL 2493
+ + HT +RV+ + VV+ S F ++ I +++ +L + A T + L
Sbjct: 1348 LTRYMPQ--NRHTFQYRVW-HFVVSPS-FEYTIMAMIALNTVVLMMK-YYSAPCTYELAL 1402
Query: 2494 NYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSX 2673
Y + FT VF++E LKVI FG + ++ R+ +N+ D + V S+T +L TD+
Sbjct: 1403 KYLNIAFTMVFSLECVLKVIAFGFL----NYFRDTWNIFDFITVIGSITEIIL-TDSKLV 1457
Query: 2674 XXXXXXXXXXXXXXAINRAKGLKH------VVQCVIVAVKTIGNIMLVTFMLQFMFAIIG 2835
A K L+ ++ + + K + + L+ ML F++AIIG
Sbjct: 1458 NTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIG 1517
Query: 2836 VQLF 2847
+Q+F
Sbjct: 1518 MQVF 1521
Score = 77.8 bits (190), Expect = 3e-12
Identities = 75/303 (24%), Positives = 124/303 (40%), Gaps = 53/303 (17%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACKHY-------PSSRGFEDFLDVFNLIFTGVFAFEAVLKIVAL 3513
FEY+I I+ N + LA + + P SR E F G+F FEA +KIVAL
Sbjct: 2 FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT----EPYFIGIFCFEAGIKIVAL 57
Query: 3514 ----NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNL---ISINFFRLFRVMRLVK 3672
+ +Y+ + WNV D +VV+ G L GT+ + + R RV+R +K
Sbjct: 58 GFIFHKGSYLRNGWNVMDFIVVLS-------GILATAGTHFNTHVDLRTLRAVRVLRPLK 110
Query: 3673 LLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHR--- 3843
L+S ++ +L + MK+ L + LL+ ++A+IG++F+ S +HR
Sbjct: 111 LVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY-------SGKLHRACF 163
Query: 3844 -NNN-----------------------------------FHSFPAAILVLFRSATGEAWQ 3915
NN+ F + A+L +F+ T E W
Sbjct: 164 MNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWT 223
Query: 3916 DIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIM 4095
++ + +D G + + YFI ++ SF V+NL + V+
Sbjct: 224 TVLYNTND---------------------ALGATWNWLYFIPLIIIGSFFVLNLVLGVLS 262
Query: 4096 DNF 4104
F
Sbjct: 263 GEF 265
Score = 76.6 bits (187), Expect = 6e-12
Identities = 116/586 (19%), Positives = 203/586 (33%), Gaps = 71/586 (12%)
Frame = +1
Query: 1531 FFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVS 1698
+F+ +F E +K+ +LGF +Y + +N D VV+S IL +F+ L
Sbjct: 41 YFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDL--R 98
Query: 1699 VLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF 1878
LR+ R+LR K+ G++ + GK
Sbjct: 99 TLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKL 158
Query: 1879 N-------------FNPQQP-------------------KPRANFDTFVQALLTVFQILT 1962
+ F+P P FD + A+LTVFQ +T
Sbjct: 159 HRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCIT 218
Query: 1963 GEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLA------- 2121
E W TV+Y+ ++ G +Y+I L I G++ +LN+ L + A
Sbjct: 219 MEGWTTVLYNTNDALGATWNW-----LYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVE 273
Query: 2122 ------------DADSLTNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSA 2265
+ N T A
Sbjct: 274 NRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEA 333
Query: 2266 RPRRMSE---VPAASTVKPIPKASSL--------FILSHTNSFRVFCNMVVNHSYFTNAV 2412
R S+ V +S P+ +AS + R+ +V F V
Sbjct: 334 MTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYWIV 393
Query: 2413 LFCILVSSAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFG--LVFHKGSF 2586
L + +++A +A Q ++ L Y ++ F +F +E++LK+ G L FH
Sbjct: 394 LSLVALNTACVAIVHHNQPQWLTHL-LYYAEFLFLGLFLLEMSLKMYGMGPRLYFH---- 448
Query: 2587 CRNAFNLLDILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQC 2757
++FN D V S+ V K L+++V
Sbjct: 449 --SSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVS 506
Query: 2758 VIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDP 2937
++ ++K+I +++ + F+ +FA++G+QLF G F ++ DG P
Sbjct: 507 LMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF-------------------NFNDGTP 547
Query: 2938 TKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
+ NFD A++++F + T E W +++Y I S
Sbjct: 548 SA-------------NFDTFPAAIMTVFQILTGEDWNEVMYNGIRS 580
Score = 69.7 bits (169), Expect = 8e-10
Identities = 62/244 (25%), Positives = 104/244 (42%), Gaps = 18/244 (7%)
Frame = +1
Query: 2398 FTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYFDYFFTSVFTVEITLKVIVFGLVF 2571
F +L I+ + +LA E L + M L + +F +F E +K++ G +F
Sbjct: 2 FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 61
Query: 2572 HKGSFCRNAFNLLDILVV-----AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKG 2736
HKGS+ RN +N++D +VV A + T F D + ++
Sbjct: 62 HKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLRT----LRAVRVLRPLKLVSGIPS 117
Query: 2737 LKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYI 2916
L+ V++ ++ A+ + I L+ F MFAIIG++ + G K+ A
Sbjct: 118 LQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSG---------KLHRACFMNNSG 168
Query: 2917 HYEDGDPTKPVS----------KKRVWSNNDF-NFDNVGDAMISLFVVSTFEGWPQLLYV 3063
E DP P K + N+ FDN+ A++++F T EGW +LY
Sbjct: 169 ILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYN 228
Query: 3064 AIDS 3075
D+
Sbjct: 229 TNDA 232
Score = 66.2 bits (160), Expect = 9e-09
Identities = 52/214 (24%), Positives = 86/214 (39%), Gaps = 17/214 (7%)
Frame = +1
Query: 1525 NLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLG--VS 1698
N+ F ++FS+E +LK+ + GF Y +N FD VI SI E +L L+ G +S
Sbjct: 1406 NIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMS 1465
Query: 1699 VLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF 1878
L+ R R+ K+ + GMQVFG
Sbjct: 1466 FLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIK 1525
Query: 1879 NFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFG---------------G 2013
NF +F +L+ +F+ TGE W +M + G
Sbjct: 1526 LDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQNENER 1585
Query: 2014 VGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDN 2115
GT + +Y++ ++++LN+F+A+ +DN
Sbjct: 1586 CGT--DLAYVYFVSFIFFCSFLMLNLFVAVIMDN 1617
>gi|27807135|ref|NP_777057.1| calcium channel, voltage-dependent, L
type, alpha 1B subunit [Bos taurus]
gi|6690638|gb|AAF24229.1| N-type calcium channel alpha1B subunit [Bos
taurus]
Length = 2331
Score = 671 bits (1730), Expect = 0.0
Identities = 354/783 (45%), Positives = 493/783 (62%), Gaps = 11/783 (1%)
Frame = +1
Query: 2308 KPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNM 2487
+PI SS+F LS TN R FC+ +V YF +L I +SS LAAEDP+Q +S RN
Sbjct: 1115 RPIVPYSSMFCLSPTNLLRRFCHYIVTMQYFEMVILVVIALSSIALAAEDPVQTDSPRNN 1174
Query: 2488 ILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL---RT 2658
+L Y DY FT VFT E+ +K+I GL+ H G++ R+ +N+LD +VV+ +L +F +
Sbjct: 1175 VLKYMDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKG 1234
Query: 2659 DAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGV 2838
+S I R LK V CV+ ++K + NI++V + F+FA+I V
Sbjct: 1235 KDISTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAV 1294
Query: 2839 QLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISL 3018
QLFKG FF C D SK E +CRG+Y+ YE + ++ R W DF++DNV A+++L
Sbjct: 1295 QLFKGKFFYCTDESKELERDCRGQYLDYEKEEVE---AQPRQWKKYDFHYDNVLWALLTL 1351
Query: 3019 FVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIVT 3198
F VST EGWP +L ++D+ E++GP R +++ +I+T
Sbjct: 1352 FTVSTGEGWPMVLKHSVDATYEEQGPSPGFRMELSIFYVVYFVVFPFFFVNIFVALIIIT 1411
Query: 3199 FQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRAFEYVIF 3372
FQ +G++ C L+KN+R CI+FA+ AKP RY+P+N+ QY+ W FV S FEY I
Sbjct: 1412 FQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNKQSFQYKTWTFVVSPPFEYFIM 1471
Query: 3373 LIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVF 3552
+I +NTV L K Y + +E L N++FT +F+ E VLK++A NY D WNVF
Sbjct: 1472 AMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKVIAFGVLNYFRDAWNVF 1531
Query: 3553 DLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQ 3732
D + V+GS DI ++ N I+++F RLFR RL+KLL +G IR LLWTF++SF+
Sbjct: 1532 DFVTVLGSITDILVTEI---ANNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFK 1588
Query: 3733 ALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAW 3912
ALPYV LLI +LFFIYA+IGMQ FG +ALDD TSI+R+NNF +F A+++LFRSATGEAW
Sbjct: 1589 ALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAW 1648
Query: 3913 QDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVI 4092
+IMLSC CD ++ N + CG++FAY YF+SF LCSFL++NLFVAVI
Sbjct: 1649 HEIMLSCLSSR--ACDELA--------NATECGSDFAYFYFVSFIFLCSFLMLNLFVAVI 1698
Query: 4093 MDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCP 4272
MDNF+YLTRD SILGPHHL+EF+R+W+EYDP A GRI + D+ +L+ +SPPLG GK CP
Sbjct: 1699 MDNFEYLTRDSSILGPHHLDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCP 1758
Query: 4273 HRLACKRLVSMNMPL-NSDGTVCFNATLFALVRTNLKIY---TEGNIDEANEQLRSAIKR 4440
R+A KRLV MNMP+ N D TV F +TL AL+RT L+I + + +LR I
Sbjct: 1759 ARVAYKRLVRMNMPISNDDMTVHFTSTLMALIRTALEIKLAPAGTKQHQCDAELRKEISS 1818
Query: 4441 IWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEM--EAKGVLPAQTP 4614
+W + LD +VPP K D++TVGK YA +I D++++ K ++ +A G L P
Sbjct: 1819 VWANLPQKTLDLLVPP-HKPDEMTVGKVYAALMIFDFYKQNKTTRDQIHQAPGGLAQMGP 1877
Query: 4615 QAM 4623
++
Sbjct: 1878 VSL 1880
Score = 508 bits (1308), Expect = e-142
Identities = 293/667 (43%), Positives = 376/667 (55%), Gaps = 27/667 (4%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N +RK I EW PFE++IL I ANCI LA+ Q P D + L+ E FI +
Sbjct: 81 DNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGI 140
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KI+A+GF+ H +YLRN WN++DF++V+ G+++T + FD++ LRA R
Sbjct: 141 FCFEAGIKIIALGFVLHKGSYLRNGWNVMDFVVVLTGILATAGTD-----FDLRTLRAVR 195
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQVVL +I++AM+PLL I LL+ F IL++AIIGLE + GK H C
Sbjct: 196 VLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFP 255
Query: 760 PATGQLAQKDPT---PCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFD 930
+T DP PCG E A C+ EC W GPN GITNFD
Sbjct: 256 NST----DADPVGDFPCGR--EAPARLCEGDT---------ECREY--WAGPNFGITNFD 298
Query: 931 NFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGE 1110
N A+LTVFQC+++EGWTD++Y NDA G W W+YF+ L+I+GSFF+LNLVLGVLSGE
Sbjct: 299 NILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFLPLIIIGSFFMLNLVLGVLSGE 358
Query: 1111 FSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDE--QEDEPVAQTXX 1284
F+KERE+ R F K R +QQ+E +L GYL+WI +AE++ ED+ +E P+
Sbjct: 359 FAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDKNAEEKSPLDVLKR 418
Query: 1285 XXXXXXXXXXXXXXXXPSKWA----------------------ARMKRLEKLNXXXXXXX 1398
++A + +R EK+
Sbjct: 419 AATKKSRNDLIHAEEGEDRFADLCAVGSPFARASLKSGKTESSSYFRRKEKM---FRFFI 475
Query: 1399 XXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYS 1578
LVK+Q+FYW HY Q + L A F+ LF EM LKMY
Sbjct: 476 RRLVKAQSFYWVVLCVVALNTLCVAMVHYQQPQRLTTALYFAEFVFLGLFLTEMSLKMYG 535
Query: 1579 LGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXX 1758
LG +Y S FN FD V++ SI E V G+SVLR+ RLLRIFKVTKYW+
Sbjct: 536 LGPRSYFRSSFNCFDFGVIVGSIFEVVWAAIKPGTSFGISVLRALRLLRIFKVTKYWSSL 595
Query: 1759 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQAL 1938
GMQ+FGG+FNF Q P NFDTF A+
Sbjct: 596 RNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF--QDETPTTNFDTFPAAI 653
Query: 1939 LTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNL 2118
LTVFQILTGEDWN VMYHGIES GGV + G+ +Y+IVL + GNY LLNVFLAIAVDNL
Sbjct: 654 LTVFQILTGEDWNAVMYHGIESQGGV-SKGMFSSVYFIVLTLFGNYTLLNVFLAIAVDNL 712
Query: 2119 ADADSLT 2139
A+A LT
Sbjct: 713 ANAQELT 719
Score = 133 bits (335), Expect = 4e-29
Identities = 95/324 (29%), Positives = 164/324 (50%), Gaps = 12/324 (3%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
N +R+ C IV + FE +IL +I + IALA P Q +N +L+ ++Y+F VF
Sbjct: 1130 NLLRRFCHYIVTMQYFEMVILVVIALSSIALAAEDP--VQTDSPRNNVLKYMDYIFTGVF 1187
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD---VKALRA 573
T E V+K++ +G + HP AY R+ WNILDFI+V LV+ S +G D +K+LR
Sbjct: 1188 TFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFS--GSKGKDISTIKSLRV 1245
Query: 574 FRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTC 753
RVLRPL+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF GK C
Sbjct: 1246 LRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF-YC 1304
Query: 754 IDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDN 933
D + + ++D D E + QP +W+ ++DN
Sbjct: 1305 TDES--KELERDCRGQYLDYEKEEVEAQPR--------QWKKYD-----------FHYDN 1343
Query: 934 FGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWP---------WIYFVTLVILGSFFVLNL 1086
A+LT+F + EGW V+ DA E I++V ++ FF +N+
Sbjct: 1344 VLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGFRMELSIFYVVYFVVFPFFFVNI 1403
Query: 1087 VLGVLSGEFSKEREKARARGLFQK 1158
+ ++ F ++ +K + +K
Sbjct: 1404 FVALIIITFQEQGDKVMSECSLEK 1427
Score = 123 bits (309), Expect = 4e-26
Identities = 81/293 (27%), Positives = 143/293 (48%), Gaps = 8/293 (2%)
Frame = +1
Query: 3268 FALKAKPHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFL 3447
F K K R +I R V +++F +V+ ++ +NT+ +A HY + L
Sbjct: 464 FRRKEKMFRFFIRR---------LVKAQSFYWVVLCVVALNTLCVAMVHYQQPQRLTTAL 514
Query: 3448 DVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLI 3627
+F G+F E LK+ L P++Y +N FD V+VGS ++ + + PG +
Sbjct: 515 YFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSIFEVVWAAIKPGTS--F 572
Query: 3628 SINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF- 3804
I+ R R++R+ K+ +R L+ + + S +++ + L+ L ++A++GMQ F
Sbjct: 573 GISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFG 632
Query: 3805 GKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYH- 3981
G+ D T NF +FPAAIL +F+ TGE W +M YH
Sbjct: 633 GQFNFQDETP---TTNFDTFPAAILTVFQILTGEDWNAVM-----------------YHG 672
Query: 3982 ---KGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF---DYLTRD 4122
+GG+++ F+ YFI + ++ ++N+F+A+ +DN LT+D
Sbjct: 673 IESQGGVSKGM----FSSVYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 721
Score = 98.2 bits (243), Expect = 2e-18
Identities = 72/295 (24%), Positives = 134/295 (45%), Gaps = 12/295 (4%)
Frame = +1
Query: 265 PFEFLILFMICANCIALAIYQPYPAQDSDYKNTL-LETIEYVFIVVFTIECVLKIVAMGF 441
PFE+ I+ MI N + L + D+ Y+ L L+ + VF +F++ECVLK++A G
Sbjct: 1465 PFEYFIMAMIALNTVVLMM----KFYDAPYEYELMLKCLNIVFTSMFSMECVLKVIAFGV 1520
Query: 442 MFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSL 621
+ Y R+AWN+ DF+ V+ + ++++++ ++ LR FR R ++L+ ++
Sbjct: 1521 L----NYFRDAWNVFDFVTVLGSITDILVTEIANNFINLSFLRLFRAARLIKLLRQGYTI 1576
Query: 622 QVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPC 801
+++L +++ L ++ LL+ + IYAIIG+++F G +A D T
Sbjct: 1577 RILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------GNIALDDDTSI 1623
Query: 802 GTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEG 981
N NF F A++ +F+ + E
Sbjct: 1624 ------------------------------------NRHNNFRTFLQALMLLFRSATGEA 1647
Query: 982 WTDVMYWVNDA-----------VGREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
W ++M + G ++ + YFV+ + L SF +LNL + V+ F
Sbjct: 1648 WHEIMLSCLSSRACDELANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1702
Score = 87.8 bits (216), Expect = 3e-15
Identities = 72/266 (27%), Positives = 119/266 (44%), Gaps = 17/266 (6%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLF+ S N R + + F +L I+ + +LA E L M L+
Sbjct: 74 SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 133
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV-----AVSLTSFVLRTDAM 2667
+ +F +F E +K+I G V HKGS+ RN +N++D +VV A + T F LRT
Sbjct: 134 EPYFIGIFCFEAGIKIIALGFVLHKGSYLRNGWNVMDFVVVLTGILATAGTDFDLRT--- 190
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
++ L+ V++ ++ A+ + I L+ F MFAIIG++ +
Sbjct: 191 -----LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY 245
Query: 2848 KGTFFLCNDLSKMTEAECRGEY-------IHYEDGDPTKPVSKKRVWSNNDF---NFDNV 2997
G F T+A+ G++ +GD + W+ +F NFDN+
Sbjct: 246 MGKFHKA-CFPNSTDADPVGDFPCGREAPARLCEGD----TECREYWAGPNFGITNFDNI 300
Query: 2998 GDAMISLFVVSTFEGWPQLLYVAIDS 3075
A++++F T EGW +LY D+
Sbjct: 301 LFAILTVFQCITMEGWTDILYNTNDA 326
Score = 85.9 bits (211), Expect = 1e-14
Identities = 76/292 (26%), Positives = 123/292 (42%), Gaps = 42/292 (14%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVA----L 3513
FEY+I I+ N + LA + H P + LD F G+F FEA +KI+A L
Sbjct: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVL 156
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WNV D +VV+ G L GT+ + R RV+R +KL+S
Sbjct: 157 HKGSYLRNGWNVMDFVVVL-------TGILATAGTD-FDLRTLRAVRVLRPLKLVSGIPS 208
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQF----FGKVALDDSTSI-------- 3837
++ +L + MK+ L + LL+ ++A+IG++F F K +ST
Sbjct: 209 LQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDADPVGDFPC 268
Query: 3838 -----------------------HRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDRED 3948
NF + AIL +F+ T E W DI+ + +D
Sbjct: 269 GREAPARLCEGDTECREYWAGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTND--- 325
Query: 3949 VRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
GN + + YF+ ++ SF ++NL + V+ F
Sbjct: 326 ------------------AAGNTWNWLYFLPLIIIGSFFMLNLVLGVLSGEF 359
Score = 73.6 bits (179), Expect = 5e-11
Identities = 109/559 (19%), Positives = 205/559 (36%), Gaps = 40/559 (7%)
Frame = +1
Query: 1534 FVILFSMEMLLKMYSLGFTTYTTSQF----NRFDCFVVISSILEFVLVYFDLMKPLGVSV 1701
F +F+ EM++KM LG + + F N D VV +++ F F K +S
Sbjct: 1183 FTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFA---FSGSKGKDIST 1239
Query: 1702 LRSARLLRIF---KVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGG 1872
++S R+LR+ K K +Q+F G
Sbjct: 1240 IKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKG 1299
Query: 1873 KFNFNPQQPK---------------------PRA------NFDTFVQALLTVFQILTGED 1971
KF + + K PR ++D + ALLT+F + TGE
Sbjct: 1300 KFFYCTDESKELERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEG 1359
Query: 1972 WNTVMYHGI----ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLT 2139
W V+ H + E G + + I+Y+V F+ + +N+F+A+ + +
Sbjct: 1360 WPMVLKHSVDATYEEQGPSPGFRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKV 1419
Query: 2140 NAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSARPRRMSEVPAASTVKPIP 2319
+ S + + A + KP+
Sbjct: 1420 MSE------------------------------------CSLEKNERACIDFAISAKPLT 1443
Query: 2320 KASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMILNY 2499
+ ++ + SF+ V F ++ I +++ +L + A ++L
Sbjct: 1444 R----YMPQNKQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKF-YDAPYEYELMLKC 1498
Query: 2500 FDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMS--X 2673
+ FTS+F++E LKVI FG++ ++ R+A+N+ D + V S+T ++ A +
Sbjct: 1499 LNIVFTSMFSMECVLKVIAFGVL----NYFRDAWNVFDFVTVLGSITDILVTEIANNFIN 1554
Query: 2674 XXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKG 2853
+ + ++ ++ + + K + + L+ ML F++AIIG+Q+F G
Sbjct: 1555 LSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-G 1613
Query: 2854 TFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVST 3033
L +D S N NF A++ LF +T
Sbjct: 1614 NIALDDDTS-----------------------------INRHNNFRTFLQALMLLFRSAT 1644
Query: 3034 FEGWPQLLYVAIDSNEEDK 3090
E W +++ + S D+
Sbjct: 1645 GEAWHEIMLSCLSSRACDE 1663
Score = 72.0 bits (175), Expect = 2e-10
Identities = 55/204 (26%), Positives = 88/204 (42%), Gaps = 7/204 (3%)
Frame = +1
Query: 1525 NLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVL 1704
N+ F +FSME +LK+ + G Y +N FD V+ SI + +LV + +S L
Sbjct: 1500 NIVFTSMFSMECVLKVIAFGVLNYFRDAWNVFDFVTVLGSITD-ILVTEIANNFINLSFL 1558
Query: 1705 RSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNF 1884
R R R+ K+ + GMQVFG
Sbjct: 1559 RLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALD 1618
Query: 1885 NPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIES-----FGGVGTLGVIVCIYY 2049
+ NF TF+QAL+ +F+ TGE W+ +M + S G +Y
Sbjct: 1619 DDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSSRACDELANATECGSDFAYFY 1678
Query: 2050 IV--LFICGNYILLNVFLAIAVDN 2115
V +F+C ++++LN+F+A+ +DN
Sbjct: 1679 FVSFIFLC-SFLMLNLFVAVIMDN 1701
Score = 58.9 bits (141), Expect = 1e-06
Identities = 57/264 (21%), Positives = 106/264 (39%), Gaps = 3/264 (1%)
Frame = +1
Query: 2293 AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN 2472
A +++K SS + FR F +V F VL C++ + + A Q
Sbjct: 449 ARASLKSGKTESSSYFRRKEKMFRFFIRRLVKAQSFYWVVL-CVVALNTLCVAMVHYQQP 507
Query: 2473 STRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL 2652
L + ++ F +F E++LK+ G S+ R++FN D V+ S+ V
Sbjct: 508 QRLTTALYFAEFVFLGLFLTEMSLKMYGLG----PRSYFRSSFNCFDFGVIVGSIFEVVW 563
Query: 2653 RTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
K L+++V ++ ++K+I +++ + F+ +F
Sbjct: 564 AAIKPGTSFGISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVF 623
Query: 2824 AIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGD 3003
A++G+QLF G F +++D PT NFD
Sbjct: 624 ALLGMQLFGGQF-------------------NFQDETPTT-------------NFDTFPA 651
Query: 3004 AMISLFVVSTFEGWPQLLYVAIDS 3075
A++++F + T E W ++Y I+S
Sbjct: 652 AILTVFQILTGEDWNAVMYHGIES 675
>gi|6166047|sp|O00555|CCAA_HUMAN Voltage-dependent P/Q-type calcium
channel alpha-1A subunit (Voltage-gated calcium channel
alpha subunit Cav2.1) (Calcium channel, L type, alpha-1
polypeptide isoform 4) (Brain calcium channel I) (BI)
Length = 2505
Score = 670 bits (1728), Expect = 0.0
Identities = 404/1021 (39%), Positives = 569/1021 (55%), Gaps = 62/1021 (6%)
Frame = +1
Query: 2308 KPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNM 2487
KP+P SS+FILS TN R C+ ++N YF +L I +SS LAAEDP+Q N+ RN
Sbjct: 1216 KPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNN 1275
Query: 2488 ILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDA- 2664
+L YFDY FT VFT E+ +K+I GLV H+G++ R+ +N+LD +VV+ +L +F ++
Sbjct: 1276 VLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSK 1335
Query: 2665 ---MSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIG 2835
++ I R LK V CV+ ++K + NI++V + F+FA++
Sbjct: 1336 GKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVA 1395
Query: 2836 VQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMIS 3015
VQLFKG FF C D SK E +CRG+Y+ YE + ++ R W +F++DNV A+++
Sbjct: 1396 VQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVK---ARDREWKKYEFHYDNVLWALLT 1452
Query: 3016 LFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIV 3195
LF VST EGWPQ+L ++D+ E++GP R +++ +I+
Sbjct: 1453 LFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIII 1512
Query: 3196 TFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRAFEYVI 3369
TFQ +G++ E L+KN+R CI+FA+ AKP R++P+N+ QYR+W FV S FEY I
Sbjct: 1513 TFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTI 1572
Query: 3370 FLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNV 3549
+I +NT+ L K Y +S +E+ L VFN++FT +F+ E VLK++A NY D WN+
Sbjct: 1573 MAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNI 1632
Query: 3550 FDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSF 3729
FD + V+GS DI + G N I+++F RLFR RL+KLL +G IR LLWTF++SF
Sbjct: 1633 FDFVTVLGSITDILVTEF---GNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSF 1689
Query: 3730 QALPYVALLIVLLFFIYAVIGMQFFGKVALD--------DSTSIHRNNNFHSFPAAILVL 3885
+ALPYV LLI +LFFIYA+IGMQ FG + +D D I +NNF +F A+++L
Sbjct: 1690 KALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLL 1749
Query: 3886 FRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFL 4065
FRSATGEAW +IMLSC + CD S G+ CGN FAY YF+SF LCSFL
Sbjct: 1750 FRSATGEAWHNIMLSCLSGKP--CDKNS------GILTRECGNEFAYFYFVSFIFLCSFL 1801
Query: 4066 VINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
++NLFVAVIMDNF+YLTRD SILGPHHL+E+VR+W+EYDP A GR+ +LD+ +LR +SP
Sbjct: 1802 MLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAAWGRMPYLDMYQMLRHMSP 1861
Query: 4246 PLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKI-YTEGNID--EANE 4416
PLG GK CP R+A KRL+ M++P+ D TV FN+TL AL+RT L I +G D + +
Sbjct: 1862 PLGLGKKCPARVAYKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDA 1921
Query: 4417 QLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRK------- 4575
+LR + IW + LD +V P K D+TVGK YA +I +Y+R+ K +K
Sbjct: 1922 ELRKEMMAIWPNLSQKTLDLLVTP-HKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAMREE 1980
Query: 4576 ---------EMEAKGVLPAQTPQAMALQA------GLRTLHEIGPE------LKRAISGN 4692
ME P AL + G HE G + +RA
Sbjct: 1981 QDRTPLMFQRMEPPSPTQEGGPGQNALPSTQLDPGGALMAHESGLKESPSWVTQRAQEMF 2040
Query: 4693 LETDFNFDEPEPQHRRPHSLFN--NLVHRLSGAGSKSPTEHERIEKGSTLLPFQPRSFSP 4866
+T E P P+S N ++ R G S +EH +G PR +
Sbjct: 2041 QKTGTWSPEQGPPTDMPNSQPNSQSVEMREMGRDGYSDSEHYLPMEGQGRAASMPRLPAE 2100
Query: 4867 THSLAGAEGSPVPSQMHRGAPINQSINLPPVNGSARR-----LPALPPYANHIHDETDDG 5031
G S + +P+ +S ++ + ARR L +PP N H +
Sbjct: 2101 NQRRRGRPRGNNLSTISDTSPMKRSASV--LGPKARRLDDYSLERVPPEENQRHHQ---- 2154
Query: 5032 PRYRDTGDRAGYDQSSRMVVANRNLPVD----------PDEEEQWMRSGGPSNRSDRRNP 5181
R RD RA R + L D P +E R G P +R R++
Sbjct: 2155 -RRRDRSHRASERSLGRYTDVDTGLGTDLSMTTQSGDLPSKERDQER-GRPKDRKHRQHH 2212
Query: 5182 H 5184
H
Sbjct: 2213 H 2213
Score = 536 bits (1381), Expect = e-150
Identities = 295/667 (44%), Positives = 383/667 (57%), Gaps = 27/667 (4%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N +RK I EW PFE++IL I ANCI LA+ Q P D + L+ E FI +
Sbjct: 84 DNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGI 143
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KI+A+GF FH +YLRN WN++DF++V+ G+++T+ ++ FD++ LRA R
Sbjct: 144 FCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE-----FDLRTLRAVR 198
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQVVL +I++AMIPLL I LL+ F ILI+AIIGLE + GK H+TC +
Sbjct: 199 VLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFE 258
Query: 760 PATGQLAQKDPTPCGTD----TEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNF 927
T + + P PCGT+ T + KCQP W GPNNGIT F
Sbjct: 259 EGTDDIQGESPAPCGTEEPARTCPNGTKCQPY-----------------WEGPNNGITQF 301
Query: 928 DNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSG 1107
DN A+LTVFQC+++EGWTD++Y NDA G W W+YF+ L+I+GSFF+LNLVLGVLSG
Sbjct: 302 DNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSG 361
Query: 1108 EFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVAQTXXX 1287
EF+KERE+ R F K R +QQ+E +L GY++WI++AE++ + EDE + E
Sbjct: 362 EFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEV-ILAEDETDGEQRHPFDGA 420
Query: 1288 XXXXXXXXXXXXXXXP-----------------SKWAARMKRLE------KLNXXXXXXX 1398
P ++ + + +LE K
Sbjct: 421 LRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFYI 480
Query: 1399 XXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYS 1578
+VK+Q FYW HY Q EWL F A F+ LF EM +KMY
Sbjct: 481 RRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYG 540
Query: 1579 LGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXX 1758
LG Y S FN FDC V+I SI E + G+SVLR+ RLLRIFKVTKYW
Sbjct: 541 LGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASL 600
Query: 1759 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQAL 1938
GMQ+FGG+FNF+ + P NFDTF A+
Sbjct: 601 RNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFD--EGTPPTNFDTFPAAI 658
Query: 1939 LTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNL 2118
+TVFQILTGEDWN VMY GI+S GGV G++ IY+IVL + GNY LLNVFLAIAVDNL
Sbjct: 659 MTVFQILTGEDWNEVMYDGIKSQGGVQG-GMVFSIYFIVLTLFGNYTLLNVFLAIAVDNL 717
Query: 2119 ADADSLT 2139
A+A LT
Sbjct: 718 ANAQELT 724
Score = 168 bits (426), Expect = 1e-39
Identities = 159/660 (24%), Positives = 278/660 (42%), Gaps = 29/660 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+R+LC I+ + FE IL +I + IALA P Q + +N +L +YVF VF
Sbjct: 1231 NPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDP--VQPNAPRNNVLRYFDYVFTGVF 1288
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD---VKALRA 573
T E V+K++ +G + H AY R+ WNILDFI+V LV+ + S +G D +K+LR
Sbjct: 1289 TFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNS-KGKDINTIKSLRV 1347
Query: 574 FRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTC 753
RVLRPL+ + +P L+ V + ++ ++ + +I ++ + + I+A++ ++LF GK C
Sbjct: 1348 LRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFH-C 1406
Query: 754 IDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDN 933
D + + +KD E + K + + W+ ++DN
Sbjct: 1407 TDES--KEFEKDCRGKYLLYEKNEVKARDRE--------WKKYE-----------FHYDN 1445
Query: 934 FGLAMLTVFQCVSLEGWTDVMYWVNDAV---------GREWPWIYFVTLVILGSFFVLNL 1086
A+LT+F + EGW V+ DA R I++V ++ FF +N+
Sbjct: 1446 VLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNI 1505
Query: 1087 VLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEP 1266
+ ++ F ++ + K E+ LE++ + +D+ A+ +
Sbjct: 1506 FVALIIITFQEQGD---------KMMEEYSLEKNERACIDFAISAKPL------------ 1544
Query: 1267 VAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXX 1446
+ + + V S F +
Sbjct: 1545 -----------------------------TRHMPQNKQSFQYRMWQFVVSPPFEYTIMAM 1575
Query: 1447 XXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDC 1626
+ YG S ++ + N+ F LFS+E +LK+ + G Y +N FD
Sbjct: 1576 IALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDF 1635
Query: 1627 FVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXX 1806
V+ SI + ++ F + +S LR R R+ K+ +
Sbjct: 1636 VTVLGSITDILVTEFG-NNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPY 1694
Query: 1807 XXXXXXXXXXXXXXXGMQVFGG--------KFNFNPQQPKPRANFDTFVQALLTVFQILT 1962
GMQVFG + + Q NF TF QAL+ +F+ T
Sbjct: 1695 VCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSAT 1754
Query: 1963 GEDWNTVMYHGI-----ESFGGVGT--LGVIVCIYYIV--LFICGNYILLNVFLAIAVDN 2115
GE W+ +M + + G+ T G +Y V +F+C ++++LN+F+A+ +DN
Sbjct: 1755 GEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1813
Score = 120 bits (300), Expect = 5e-25
Identities = 73/274 (26%), Positives = 139/274 (50%), Gaps = 4/274 (1%)
Frame = +1
Query: 3313 RLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEA 3492
R+++ + V ++AF + + ++ +NT+ +A HY DFL IF G+F E
Sbjct: 475 RMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEM 534
Query: 3493 VLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVK 3672
+K+ L + Y +N FD V++GS ++ + + PG + I+ R R++R+ K
Sbjct: 535 FIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTS--FGISVLRALRLLRIFK 592
Query: 3673 LLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNN 3849
+ +R L+ + + S +++ + L+ L ++A++GMQ F G+ D+ T
Sbjct: 593 VTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTP---PT 649
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FPAAI+ +F+ TGE W ++M + ++ +GG+ G
Sbjct: 650 NFDTFPAAIMTVFQILTGEDWNEVMY-----DGIK--------SQGGVQ----GGMVFSI 692
Query: 4030 YFISFFMLCSFLVINLFVAVIMDNF---DYLTRD 4122
YFI + ++ ++N+F+A+ +DN LT+D
Sbjct: 693 YFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 726
Score = 95.5 bits (236), Expect = 1e-17
Identities = 73/296 (24%), Positives = 130/296 (43%), Gaps = 13/296 (4%)
Frame = +1
Query: 265 PFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFM 444
PFE+ I+ MI N I L + + Y+N L VF +F++ECVLK++A G +
Sbjct: 1567 PFEYTIMAMIALNTIVLMM--KFYGASVAYENAL-RVFNIVFTSLFSLECVLKVMAFGIL 1623
Query: 445 FHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQ 624
Y R+AWNI DF+ V+ + ++++ ++ LR FR R ++L+ +++
Sbjct: 1624 ----NYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIR 1679
Query: 625 VVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCG 804
++L +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1680 ILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF------------------------- 1714
Query: 805 TDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGW 984
N+G+ E + NF F A++ +F+ + E W
Sbjct: 1715 ----------------GNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAW 1758
Query: 985 TDVMYWV--------NDAV-----GREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
++M N + G E+ + YFV+ + L SF +LNL + V+ F
Sbjct: 1759 HNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1814
Score = 86.7 bits (213), Expect = 6e-15
Identities = 70/263 (26%), Positives = 117/263 (43%), Gaps = 13/263 (4%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLF+ S N R + + F +L I+ + +LA E L + M L+
Sbjct: 77 SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSL-----TSFVLRTDAM 2667
+ +F +F E +K+I G FHKGS+ RN +N++D +VV + T F LRT
Sbjct: 137 EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRT--- 193
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
++ L+ V++ ++ A+ + I L+ F +FAIIG++ +
Sbjct: 194 -----LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFY 248
Query: 2848 KGTFFL------CNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAM 3009
G F +D+ + A C E + TK +N FDN+ A+
Sbjct: 249 MGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAV 308
Query: 3010 ISLFVVSTFEGWPQLLYVAIDSN 3078
+++F T EGW LLY + D++
Sbjct: 309 LTVFQCITMEGWTDLLYNSNDAS 331
Score = 80.9 bits (198), Expect = 3e-13
Identities = 75/293 (25%), Positives = 123/293 (41%), Gaps = 43/293 (14%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY+I I+ N + LA + H P + LD F G+F FEA +KI+AL
Sbjct: 100 FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WNV D +VV+ G L GT + R RV+R +KL+S
Sbjct: 160 HKGSYLRNGWNVMDFVVVL-------TGILATVGTE-FDLRTLRAVRVLRPLKLVSGIPS 211
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQF----FGKVALDDSTSIHR------ 3843
++ +L + MK+ L + LL+ I+A+IG++F F ++ T +
Sbjct: 212 LQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAP 271
Query: 3844 -----------------------NN---NFHSFPAAILVLFRSATGEAWQDIMLSCSDRE 3945
NN F + A+L +F+ T E W D++ + +D
Sbjct: 272 CGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDAS 331
Query: 3946 DVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
GN + + YFI ++ SF ++NL + V+ F
Sbjct: 332 ---------------------GNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 363
Score = 75.9 bits (185), Expect = 1e-11
Identities = 72/322 (22%), Positives = 140/322 (43%), Gaps = 16/322 (4%)
Frame = +1
Query: 250 IVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIV 429
+V+ + F + +L ++ N + +AI ++ + L E++F+ +F E +K+
Sbjct: 483 MVKTQAFYWTVLSLVALNTLCVAIVH---YNQPEWLSDFLYYAEFIFLGLFMSEMFIKMY 539
Query: 430 AMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKALRAFRVLRPLRLV 603
+G Y +++N D V+IG + ++ + G F + LRA R+LR ++
Sbjct: 540 GLG----TRPYFHSSFNCFD-CGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVT 594
Query: 604 SGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ 783
SL+ ++ ++L +M ++ + L+ I+++A++G++LF GQ
Sbjct: 595 KYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLF------------GGQFNF 642
Query: 784 KDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQ 963
+ TP TNFD F A++TVFQ
Sbjct: 643 DEGTPP---------------------------------------TNFDTFPAAIMTVFQ 663
Query: 964 CVSLEGWTDVMY-WVNDAVGREWPW---IYFVTLVILGSFFVLNLVLGV----------L 1101
++ E W +VMY + G + IYF+ L + G++ +LN+ L + L
Sbjct: 664 ILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQEL 723
Query: 1102 SGEFSKEREKARARGLFQKFRE 1167
+ + +E E A + QK +E
Sbjct: 724 TKDEQEEEEAANQKLALQKAKE 745
Score = 46.2 bits (108), Expect = 0.009
Identities = 50/264 (18%), Positives = 103/264 (38%), Gaps = 3/264 (1%)
Frame = +1
Query: 2293 AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN 2472
A +++K +S F R + +V F VL + +++ +A Q
Sbjct: 454 ARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPE 513
Query: 2473 STRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL 2652
+ L Y ++ F +F E+ +K+ G + ++FN D V+ S+ +
Sbjct: 514 WLSDF-LYYAEFIFLGLFMSEMFIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIW 568
Query: 2653 RTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
K L+++V ++ ++K+I +++ + F+ +F
Sbjct: 569 AVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
Query: 2824 AIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGD 3003
A++G+QLF G F ++++G P NFD
Sbjct: 629 ALLGMQLFGGQF-------------------NFDEGTPPT-------------NFDTFPA 656
Query: 3004 AMISLFVVSTFEGWPQLLYVAIDS 3075
A++++F + T E W +++Y I S
Sbjct: 657 AIMTVFQILTGEDWNEVMYDGIKS 680
>gi|9711929|dbj|BAA94766.2| alpha1A-voltage-dependent calcium channel
[Homo sapiens]
Length = 2506
Score = 670 bits (1728), Expect = 0.0
Identities = 404/1021 (39%), Positives = 569/1021 (55%), Gaps = 62/1021 (6%)
Frame = +1
Query: 2308 KPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNM 2487
KP+P SS+FILS TN R C+ ++N YF +L I +SS LAAEDP+Q N+ RN
Sbjct: 1215 KPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNN 1274
Query: 2488 ILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDA- 2664
+L YFDY FT VFT E+ +K+I GLV H+G++ R+ +N+LD +VV+ +L +F ++
Sbjct: 1275 VLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSK 1334
Query: 2665 ---MSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIG 2835
++ I R LK V CV+ ++K + NI++V + F+FA++
Sbjct: 1335 GKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVA 1394
Query: 2836 VQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMIS 3015
VQLFKG FF C D SK E +CRG+Y+ YE + ++ R W +F++DNV A+++
Sbjct: 1395 VQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVK---ARDREWKKYEFHYDNVLWALLT 1451
Query: 3016 LFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIV 3195
LF VST EGWPQ+L ++D+ E++GP R +++ +I+
Sbjct: 1452 LFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIII 1511
Query: 3196 TFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRAFEYVI 3369
TFQ +G++ E L+KN+R CI+FA+ AKP R++P+N+ QYR+W FV S FEY I
Sbjct: 1512 TFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTI 1571
Query: 3370 FLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNV 3549
+I +NT+ L K Y +S +E+ L VFN++FT +F+ E VLK++A NY D WN+
Sbjct: 1572 MAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNI 1631
Query: 3550 FDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSF 3729
FD + V+GS DI + G N I+++F RLFR RL+KLL +G IR LLWTF++SF
Sbjct: 1632 FDFVTVLGSITDILVTEF---GNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSF 1688
Query: 3730 QALPYVALLIVLLFFIYAVIGMQFFGKVALD--------DSTSIHRNNNFHSFPAAILVL 3885
+ALPYV LLI +LFFIYA+IGMQ FG + +D D I +NNF +F A+++L
Sbjct: 1689 KALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLL 1748
Query: 3886 FRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFL 4065
FRSATGEAW +IMLSC + CD S G+ CGN FAY YF+SF LCSFL
Sbjct: 1749 FRSATGEAWHNIMLSCLSGKP--CDKNS------GILTRECGNEFAYFYFVSFIFLCSFL 1800
Query: 4066 VINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
++NLFVAVIMDNF+YLTRD SILGPHHL+E+VR+W+EYDP A GR+ +LD+ +LR +SP
Sbjct: 1801 MLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAAWGRMPYLDMYQMLRHMSP 1860
Query: 4246 PLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKI-YTEGNID--EANE 4416
PLG GK CP R+A KRL+ M++P+ D TV FN+TL AL+RT L I +G D + +
Sbjct: 1861 PLGLGKKCPARVAYKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDA 1920
Query: 4417 QLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRK------- 4575
+LR + IW + LD +V P K D+TVGK YA +I +Y+R+ K +K
Sbjct: 1921 ELRKEMMAIWPNLSQKTLDLLVTP-HKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAMREE 1979
Query: 4576 ---------EMEAKGVLPAQTPQAMALQA------GLRTLHEIGPE------LKRAISGN 4692
ME P AL + G HE G + +RA
Sbjct: 1980 QDRTPLMFQRMEPPSPTQEGGPGQNALPSTQLDPGGALMAHESGLKESPSWVTQRAQEMF 2039
Query: 4693 LETDFNFDEPEPQHRRPHSLFN--NLVHRLSGAGSKSPTEHERIEKGSTLLPFQPRSFSP 4866
+T E P P+S N ++ R G S +EH +G PR +
Sbjct: 2040 QKTGTWSPEQGPPTDMPNSQPNSQSVEMREMGRDGYSDSEHYLPMEGQGRAASMPRLPAE 2099
Query: 4867 THSLAGAEGSPVPSQMHRGAPINQSINLPPVNGSARR-----LPALPPYANHIHDETDDG 5031
G S + +P+ +S ++ + ARR L +PP N H +
Sbjct: 2100 NQRRRGRPRGNNLSTISDTSPMKRSASV--LGPKARRLDDYSLERVPPEENQRHHQ---- 2153
Query: 5032 PRYRDTGDRAGYDQSSRMVVANRNLPVD----------PDEEEQWMRSGGPSNRSDRRNP 5181
R RD RA R + L D P +E R G P +R R++
Sbjct: 2154 -RRRDRSHRASERSLGRYTDVDTGLGTDLSMTTQSGDLPSKERDQER-GRPKDRKHRQHH 2211
Query: 5182 H 5184
H
Sbjct: 2212 H 2212
Score = 536 bits (1382), Expect = e-150
Identities = 296/666 (44%), Positives = 383/666 (57%), Gaps = 26/666 (3%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N +RK I EW PFE++IL I ANCI LA+ Q P D + L+ E FI +
Sbjct: 84 DNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGI 143
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KI+A+GF FH +YLRN WN++DF++V+ G+++T+ ++ FD++ LRA R
Sbjct: 144 FCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE-----FDLRTLRAVR 198
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQVVL +I++AMIPLL I LL+ F ILI+AIIGLE + GK H+TC +
Sbjct: 199 VLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFE 258
Query: 760 PATGQLAQKDPTPCGTD----TEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNF 927
T + + P PCGT+ T + KCQP W GPNNGIT F
Sbjct: 259 EGTDDIQGESPAPCGTEEPARTCPNGTKCQPY-----------------WEGPNNGITQF 301
Query: 928 DNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSG 1107
DN A+LTVFQC+++EGWTD++Y NDA G W W+YF+ L+I+GSFF+LNLVLGVLSG
Sbjct: 302 DNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSG 361
Query: 1108 EFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDE-------- 1263
EF+KERE+ R F K R +QQ+E +L GY++WI++AE++ + EDE + E
Sbjct: 362 EFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEV-ILAEDETDGEQRHPFDAL 420
Query: 1264 -----PVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXX---------XXXXX 1401
++T S +A + KL
Sbjct: 421 RRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFYIR 480
Query: 1402 XLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSL 1581
+VK+Q FYW HY Q EWL F A F+ LF EM +KMY L
Sbjct: 481 RMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGL 540
Query: 1582 GFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXX 1761
G Y S FN FDC V+I SI E + G+SVLR+ RLLRIFKVTKYW
Sbjct: 541 GTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASLR 600
Query: 1762 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALL 1941
GMQ+FGG+FNF+ + P NFDTF A++
Sbjct: 601 NLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFD--EGTPPTNFDTFPAAIM 658
Query: 1942 TVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLA 2121
TVFQILTGEDWN VMY GI+S GGV G++ IY+IVL + GNY LLNVFLAIAVDNLA
Sbjct: 659 TVFQILTGEDWNEVMYDGIKSQGGVQG-GMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLA 717
Query: 2122 DADSLT 2139
+A LT
Sbjct: 718 NAQELT 723
Score = 168 bits (426), Expect = 1e-39
Identities = 159/660 (24%), Positives = 278/660 (42%), Gaps = 29/660 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+R+LC I+ + FE IL +I + IALA P Q + +N +L +YVF VF
Sbjct: 1230 NPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDP--VQPNAPRNNVLRYFDYVFTGVF 1287
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD---VKALRA 573
T E V+K++ +G + H AY R+ WNILDFI+V LV+ + S +G D +K+LR
Sbjct: 1288 TFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNS-KGKDINTIKSLRV 1346
Query: 574 FRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTC 753
RVLRPL+ + +P L+ V + ++ ++ + +I ++ + + I+A++ ++LF GK C
Sbjct: 1347 LRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFH-C 1405
Query: 754 IDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDN 933
D + + +KD E + K + + W+ ++DN
Sbjct: 1406 TDES--KEFEKDCRGKYLLYEKNEVKARDRE--------WKKYE-----------FHYDN 1444
Query: 934 FGLAMLTVFQCVSLEGWTDVMYWVNDAV---------GREWPWIYFVTLVILGSFFVLNL 1086
A+LT+F + EGW V+ DA R I++V ++ FF +N+
Sbjct: 1445 VLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNI 1504
Query: 1087 VLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEP 1266
+ ++ F ++ + K E+ LE++ + +D+ A+ +
Sbjct: 1505 FVALIIITFQEQGD---------KMMEEYSLEKNERACIDFAISAKPL------------ 1543
Query: 1267 VAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXX 1446
+ + + V S F +
Sbjct: 1544 -----------------------------TRHMPQNKQSFQYRMWQFVVSPPFEYTIMAM 1574
Query: 1447 XXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDC 1626
+ YG S ++ + N+ F LFS+E +LK+ + G Y +N FD
Sbjct: 1575 IALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDF 1634
Query: 1627 FVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXX 1806
V+ SI + ++ F + +S LR R R+ K+ +
Sbjct: 1635 VTVLGSITDILVTEFG-NNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPY 1693
Query: 1807 XXXXXXXXXXXXXXXGMQVFGG--------KFNFNPQQPKPRANFDTFVQALLTVFQILT 1962
GMQVFG + + Q NF TF QAL+ +F+ T
Sbjct: 1694 VCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSAT 1753
Query: 1963 GEDWNTVMYHGI-----ESFGGVGT--LGVIVCIYYIV--LFICGNYILLNVFLAIAVDN 2115
GE W+ +M + + G+ T G +Y V +F+C ++++LN+F+A+ +DN
Sbjct: 1754 GEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1812
Score = 120 bits (300), Expect = 5e-25
Identities = 73/274 (26%), Positives = 139/274 (50%), Gaps = 4/274 (1%)
Frame = +1
Query: 3313 RLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEA 3492
R+++ + V ++AF + + ++ +NT+ +A HY DFL IF G+F E
Sbjct: 474 RMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEM 533
Query: 3493 VLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVK 3672
+K+ L + Y +N FD V++GS ++ + + PG + I+ R R++R+ K
Sbjct: 534 FIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTS--FGISVLRALRLLRIFK 591
Query: 3673 LLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNN 3849
+ +R L+ + + S +++ + L+ L ++A++GMQ F G+ D+ T
Sbjct: 592 VTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTP---PT 648
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FPAAI+ +F+ TGE W ++M + ++ +GG+ G
Sbjct: 649 NFDTFPAAIMTVFQILTGEDWNEVMY-----DGIK--------SQGGVQ----GGMVFSI 691
Query: 4030 YFISFFMLCSFLVINLFVAVIMDNF---DYLTRD 4122
YFI + ++ ++N+F+A+ +DN LT+D
Sbjct: 692 YFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 725
Score = 95.5 bits (236), Expect = 1e-17
Identities = 73/296 (24%), Positives = 130/296 (43%), Gaps = 13/296 (4%)
Frame = +1
Query: 265 PFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFM 444
PFE+ I+ MI N I L + + Y+N L VF +F++ECVLK++A G +
Sbjct: 1566 PFEYTIMAMIALNTIVLMM--KFYGASVAYENAL-RVFNIVFTSLFSLECVLKVMAFGIL 1622
Query: 445 FHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQ 624
Y R+AWNI DF+ V+ + ++++ ++ LR FR R ++L+ +++
Sbjct: 1623 ----NYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIR 1678
Query: 625 VVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCG 804
++L +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1679 ILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF------------------------- 1713
Query: 805 TDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGW 984
N+G+ E + NF F A++ +F+ + E W
Sbjct: 1714 ----------------GNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAW 1757
Query: 985 TDVMYWV--------NDAV-----GREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
++M N + G E+ + YFV+ + L SF +LNL + V+ F
Sbjct: 1758 HNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1813
Score = 86.7 bits (213), Expect = 6e-15
Identities = 70/263 (26%), Positives = 117/263 (43%), Gaps = 13/263 (4%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLF+ S N R + + F +L I+ + +LA E L + M L+
Sbjct: 77 SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSL-----TSFVLRTDAM 2667
+ +F +F E +K+I G FHKGS+ RN +N++D +VV + T F LRT
Sbjct: 137 EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRT--- 193
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
++ L+ V++ ++ A+ + I L+ F +FAIIG++ +
Sbjct: 194 -----LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFY 248
Query: 2848 KGTFFL------CNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAM 3009
G F +D+ + A C E + TK +N FDN+ A+
Sbjct: 249 MGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAV 308
Query: 3010 ISLFVVSTFEGWPQLLYVAIDSN 3078
+++F T EGW LLY + D++
Sbjct: 309 LTVFQCITMEGWTDLLYNSNDAS 331
Score = 80.9 bits (198), Expect = 3e-13
Identities = 75/293 (25%), Positives = 123/293 (41%), Gaps = 43/293 (14%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY+I I+ N + LA + H P + LD F G+F FEA +KI+AL
Sbjct: 100 FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WNV D +VV+ G L GT + R RV+R +KL+S
Sbjct: 160 HKGSYLRNGWNVMDFVVVL-------TGILATVGTE-FDLRTLRAVRVLRPLKLVSGIPS 211
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQF----FGKVALDDSTSIHR------ 3843
++ +L + MK+ L + LL+ I+A+IG++F F ++ T +
Sbjct: 212 LQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAP 271
Query: 3844 -----------------------NN---NFHSFPAAILVLFRSATGEAWQDIMLSCSDRE 3945
NN F + A+L +F+ T E W D++ + +D
Sbjct: 272 CGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDAS 331
Query: 3946 DVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
GN + + YFI ++ SF ++NL + V+ F
Sbjct: 332 ---------------------GNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 363
Score = 75.9 bits (185), Expect = 1e-11
Identities = 72/322 (22%), Positives = 140/322 (43%), Gaps = 16/322 (4%)
Frame = +1
Query: 250 IVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIV 429
+V+ + F + +L ++ N + +AI ++ + L E++F+ +F E +K+
Sbjct: 482 MVKTQAFYWTVLSLVALNTLCVAIVH---YNQPEWLSDFLYYAEFIFLGLFMSEMFIKMY 538
Query: 430 AMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKALRAFRVLRPLRLV 603
+G Y +++N D V+IG + ++ + G F + LRA R+LR ++
Sbjct: 539 GLG----TRPYFHSSFNCFD-CGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVT 593
Query: 604 SGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ 783
SL+ ++ ++L +M ++ + L+ I+++A++G++LF GQ
Sbjct: 594 KYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLF------------GGQFNF 641
Query: 784 KDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQ 963
+ TP TNFD F A++TVFQ
Sbjct: 642 DEGTPP---------------------------------------TNFDTFPAAIMTVFQ 662
Query: 964 CVSLEGWTDVMY-WVNDAVGREWPW---IYFVTLVILGSFFVLNLVLGV----------L 1101
++ E W +VMY + G + IYF+ L + G++ +LN+ L + L
Sbjct: 663 ILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQEL 722
Query: 1102 SGEFSKEREKARARGLFQKFRE 1167
+ + +E E A + QK +E
Sbjct: 723 TKDEQEEEEAANQKLALQKAKE 744
Score = 46.2 bits (108), Expect = 0.009
Identities = 50/264 (18%), Positives = 103/264 (38%), Gaps = 3/264 (1%)
Frame = +1
Query: 2293 AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN 2472
A +++K +S F R + +V F VL + +++ +A Q
Sbjct: 453 ARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPE 512
Query: 2473 STRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL 2652
+ L Y ++ F +F E+ +K+ G + ++FN D V+ S+ +
Sbjct: 513 WLSDF-LYYAEFIFLGLFMSEMFIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIW 567
Query: 2653 RTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
K L+++V ++ ++K+I +++ + F+ +F
Sbjct: 568 AVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 627
Query: 2824 AIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGD 3003
A++G+QLF G F ++++G P NFD
Sbjct: 628 ALLGMQLFGGQF-------------------NFDEGTPPT-------------NFDTFPA 655
Query: 3004 AMISLFVVSTFEGWPQLLYVAIDS 3075
A++++F + T E W +++Y I S
Sbjct: 656 AIMTVFQILTGEDWNEVMYDGIKS 679
>gi|2213913|gb|AAB61613.1| neuronal calcium channel alpha 1A subunit
isoform A-1 [Homo sapiens]
Length = 2510
Score = 668 bits (1724), Expect = 0.0
Identities = 405/1022 (39%), Positives = 570/1022 (55%), Gaps = 63/1022 (6%)
Frame = +1
Query: 2308 KPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNM 2487
KP+P SS+FILS TN R C+ ++N YF +L I +SS LAAEDP+Q N+ RN
Sbjct: 1219 KPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNN 1278
Query: 2488 ILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDA- 2664
+L YFDY FT VFT E+ +K+I GLV H+G++ R+ +N+LD +VV+ +L +F ++
Sbjct: 1279 VLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSK 1338
Query: 2665 ---MSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIG 2835
++ I R LK V CV+ ++K + NI++V + F+FA++
Sbjct: 1339 GKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVA 1398
Query: 2836 VQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMIS 3015
VQLFKG FF C D SK E +CRG+Y+ YE + ++ R W +F++DNV A+++
Sbjct: 1399 VQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVK---ARDREWKKYEFHYDNVLWALLT 1455
Query: 3016 LFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIV 3195
LF VST EGWPQ+L ++D+ E++GP R +++ +I+
Sbjct: 1456 LFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIII 1515
Query: 3196 TFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRAFEYVI 3369
TFQ +G++ E L+KN+R CI+FA+ AKP R++P+N+ QYR+W FV S FEY I
Sbjct: 1516 TFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTI 1575
Query: 3370 FLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNV 3549
+I +NT+ L K Y +S +E+ L VFN++FT +F+ E VLK++A NY D WN+
Sbjct: 1576 MAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNI 1635
Query: 3550 FDLLVVVGSFIDITYGKL-NPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKS 3726
FD + V+GS DI + NP N I+++F RLFR RL+KLL +G IR LLWTF++S
Sbjct: 1636 FDFVTVLGSITDILVTEFGNPN--NFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQS 1693
Query: 3727 FQALPYVALLIVLLFFIYAVIGMQFFGKVALD--------DSTSIHRNNNFHSFPAAILV 3882
F+ALPYV LLI +LFFIYA+IGMQ FG + +D D I +NNF +F A+++
Sbjct: 1694 FKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALML 1753
Query: 3883 LFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSF 4062
LFRSATGEAW +IMLSC + CD S G+ CGN FAY YF+SF LCSF
Sbjct: 1754 LFRSATGEAWHNIMLSCLSGKP--CDKNS------GILTRECGNEFAYFYFVSFIFLCSF 1805
Query: 4063 LVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKIS 4242
L++NLFVAVIMDNF+YLTRD SILGPHHL+E+VR+W+EYDP A GR+ +LD+ +LR +S
Sbjct: 1806 LMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAAWGRMPYLDMYQMLRHMS 1865
Query: 4243 PPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKI-YTEGNID--EAN 4413
PPLG GK CP R+A KRL+ M++P+ D TV FN+TL AL+RT L I +G D + +
Sbjct: 1866 PPLGLGKKCPARVAYKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMD 1925
Query: 4414 EQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRK------ 4575
+LR + IW + LD +V P K D+TVGK YA +I +Y+R+ K +K
Sbjct: 1926 AELRKEMMAIWPNLSQKTLDLLVTP-HKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAMRE 1984
Query: 4576 ----------EMEAKGVLPAQTPQAMALQA------GLRTLHEIGPE------LKRAISG 4689
ME P AL + G HE G + +RA
Sbjct: 1985 EQDRTPLMFQRMEPPSPTQEGGPGQNALPSTQLDPGGALMAHESGLKESPSWVTQRAQEM 2044
Query: 4690 NLETDFNFDEPEPQHRRPHSLFN--NLVHRLSGAGSKSPTEHERIEKGSTLLPFQPRSFS 4863
+T E P P+S N ++ R G S +EH +G PR +
Sbjct: 2045 FQKTGTWSPEQGPPTDMPNSQPNSQSVEMREMGRDGYSDSEHYLPMEGQGRAASMPRLPA 2104
Query: 4864 PTHSLAGAEGSPVPSQMHRGAPINQSINLPPVNGSARR-----LPALPPYANHIHDETDD 5028
G S + +P+ +S ++ + ARR L +PP N H +
Sbjct: 2105 ENQRRRGRPRGNNLSTISDTSPMKRSASV--LGPKARRLDDYSLERVPPEENQRHHQ--- 2159
Query: 5029 GPRYRDTGDRAGYDQSSRMVVANRNLPVD----------PDEEEQWMRSGGPSNRSDRRN 5178
R RD RA R + L D P +E R G P +R R++
Sbjct: 2160 --RRRDRSHRASERSLGRYTDVDTGLGTDLSMTTQSGDLPSKERDQER-GRPKDRKHRQH 2216
Query: 5179 PH 5184
H
Sbjct: 2217 HH 2218
Score = 536 bits (1381), Expect = e-150
Identities = 295/667 (44%), Positives = 383/667 (57%), Gaps = 27/667 (4%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N +RK I EW PFE++IL I ANCI LA+ Q P D + L+ E FI +
Sbjct: 84 DNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGI 143
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KI+A+GF FH +YLRN WN++DF++V+ G+++T+ ++ FD++ LRA R
Sbjct: 144 FCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE-----FDLRTLRAVR 198
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQVVL +I++AMIPLL I LL+ F ILI+AIIGLE + GK H+TC +
Sbjct: 199 VLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFE 258
Query: 760 PATGQLAQKDPTPCGTD----TEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNF 927
T + + P PCGT+ T + KCQP W GPNNGIT F
Sbjct: 259 EGTDDIQGESPAPCGTEEPARTCPNGTKCQPY-----------------WEGPNNGITQF 301
Query: 928 DNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSG 1107
DN A+LTVFQC+++EGWTD++Y NDA G W W+YF+ L+I+GSFF+LNLVLGVLSG
Sbjct: 302 DNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSG 361
Query: 1108 EFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVAQTXXX 1287
EF+KERE+ R F K R +QQ+E +L GY++WI++AE++ + EDE + E
Sbjct: 362 EFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEV-ILAEDETDGEQRHPFDGA 420
Query: 1288 XXXXXXXXXXXXXXXP-----------------SKWAARMKRLE------KLNXXXXXXX 1398
P ++ + + +LE K
Sbjct: 421 LRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFYI 480
Query: 1399 XXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYS 1578
+VK+Q FYW HY Q EWL F A F+ LF EM +KMY
Sbjct: 481 RRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYG 540
Query: 1579 LGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXX 1758
LG Y S FN FDC V+I SI E + G+SVLR+ RLLRIFKVTKYW
Sbjct: 541 LGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASL 600
Query: 1759 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQAL 1938
GMQ+FGG+FNF+ + P NFDTF A+
Sbjct: 601 RNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFD--EGTPPTNFDTFPAAI 658
Query: 1939 LTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNL 2118
+TVFQILTGEDWN VMY GI+S GGV G++ IY+IVL + GNY LLNVFLAIAVDNL
Sbjct: 659 MTVFQILTGEDWNEVMYDGIKSQGGVQG-GMVFSIYFIVLTLFGNYTLLNVFLAIAVDNL 717
Query: 2119 ADADSLT 2139
A+A LT
Sbjct: 718 ANAQELT 724
Score = 168 bits (425), Expect = 2e-39
Identities = 159/661 (24%), Positives = 279/661 (42%), Gaps = 30/661 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+R+LC I+ + FE IL +I + IALA P Q + +N +L +YVF VF
Sbjct: 1234 NPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDP--VQPNAPRNNVLRYFDYVFTGVF 1291
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD---VKALRA 573
T E V+K++ +G + H AY R+ WNILDFI+V LV+ + S +G D +K+LR
Sbjct: 1292 TFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNS-KGKDINTIKSLRV 1350
Query: 574 FRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTC 753
RVLRPL+ + +P L+ V + ++ ++ + +I ++ + + I+A++ ++LF GK C
Sbjct: 1351 LRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFH-C 1409
Query: 754 IDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDN 933
D + + +KD E + K + + W+ ++DN
Sbjct: 1410 TDES--KEFEKDCRGKYLLYEKNEVKARDRE--------WKKYE-----------FHYDN 1448
Query: 934 FGLAMLTVFQCVSLEGWTDVMYWVNDAV---------GREWPWIYFVTLVILGSFFVLNL 1086
A+LT+F + EGW V+ DA R I++V ++ FF +N+
Sbjct: 1449 VLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNI 1508
Query: 1087 VLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEP 1266
+ ++ F ++ + K E+ LE++ + +D+ A+ +
Sbjct: 1509 FVALIIITFQEQGD---------KMMEEYSLEKNERACIDFAISAKPL------------ 1547
Query: 1267 VAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXX 1446
+ + + V S F +
Sbjct: 1548 -----------------------------TRHMPQNKQSFQYRMWQFVVSPPFEYTIMAM 1578
Query: 1447 XXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDC 1626
+ YG S ++ + N+ F LFS+E +LK+ + G Y +N FD
Sbjct: 1579 IALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDF 1638
Query: 1627 FVVISSILEFVLVYF-DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXX 1803
V+ SI + ++ F + + +S LR R R+ K+ +
Sbjct: 1639 VTVLGSITDILVTEFGNPNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALP 1698
Query: 1804 XXXXXXXXXXXXXXXXGMQVFGG--------KFNFNPQQPKPRANFDTFVQALLTVFQIL 1959
GMQVFG + + Q NF TF QAL+ +F+
Sbjct: 1699 YVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSA 1758
Query: 1960 TGEDWNTVMYHGI-----ESFGGVGT--LGVIVCIYYIV--LFICGNYILLNVFLAIAVD 2112
TGE W+ +M + + G+ T G +Y V +F+C ++++LN+F+A+ +D
Sbjct: 1759 TGEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMD 1817
Query: 2113 N 2115
N
Sbjct: 1818 N 1818
Score = 119 bits (299), Expect = 6e-25
Identities = 70/264 (26%), Positives = 135/264 (50%), Gaps = 1/264 (0%)
Frame = +1
Query: 3313 RLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEA 3492
R+++ + V ++AF + + ++ +NT+ +A HY DFL IF G+F E
Sbjct: 475 RMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEM 534
Query: 3493 VLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVK 3672
+K+ L + Y +N FD V++GS ++ + + PG + I+ R R++R+ K
Sbjct: 535 FIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTS--FGISVLRALRLLRIFK 592
Query: 3673 LLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNN 3849
+ +R L+ + + S +++ + L+ L ++A++GMQ F G+ D+ T
Sbjct: 593 VTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTP---PT 649
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FPAAI+ +F+ TGE W ++M + ++ +GG+ G
Sbjct: 650 NFDTFPAAIMTVFQILTGEDWNEVMY-----DGIK--------SQGGVQ----GGMVFSI 692
Query: 4030 YFISFFMLCSFLVINLFVAVIMDN 4101
YFI + ++ ++N+F+A+ +DN
Sbjct: 693 YFIVLTLFGNYTLLNVFLAIAVDN 716
Score = 91.3 bits (225), Expect = 2e-16
Identities = 73/298 (24%), Positives = 130/298 (43%), Gaps = 15/298 (5%)
Frame = +1
Query: 265 PFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFM 444
PFE+ I+ MI N I L + + Y+N L VF +F++ECVLK++A G +
Sbjct: 1570 PFEYTIMAMIALNTIVLMM--KFYGASVAYENAL-RVFNIVFTSLFSLECVLKVMAFGIL 1626
Query: 445 FHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKALRAFRVLRPLRLVSGVPS 618
Y R+AWNI DF+ V+ + ++++ ++ LR FR R ++L+ +
Sbjct: 1627 ----NYFRDAWNIFDFVTVLGSITDILVTEFGNPNNFINLSFLRLFRAARLIKLLRQGYT 1682
Query: 619 LQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTP 798
++++L +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1683 IRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF----------------------- 1719
Query: 799 CGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLE 978
N+G+ E + NF F A++ +F+ + E
Sbjct: 1720 ------------------GNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGE 1761
Query: 979 GWTDVMYWV--------NDAV-----GREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
W ++M N + G E+ + YFV+ + L SF +LNL + V+ F
Sbjct: 1762 AWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1819
Score = 86.7 bits (213), Expect = 6e-15
Identities = 70/263 (26%), Positives = 117/263 (43%), Gaps = 13/263 (4%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLF+ S N R + + F +L I+ + +LA E L + M L+
Sbjct: 77 SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSL-----TSFVLRTDAM 2667
+ +F +F E +K+I G FHKGS+ RN +N++D +VV + T F LRT
Sbjct: 137 EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRT--- 193
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
++ L+ V++ ++ A+ + I L+ F +FAIIG++ +
Sbjct: 194 -----LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFY 248
Query: 2848 KGTFFL------CNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAM 3009
G F +D+ + A C E + TK +N FDN+ A+
Sbjct: 249 MGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAV 308
Query: 3010 ISLFVVSTFEGWPQLLYVAIDSN 3078
+++F T EGW LLY + D++
Sbjct: 309 LTVFQCITMEGWTDLLYNSNDAS 331
Score = 80.9 bits (198), Expect = 3e-13
Identities = 75/293 (25%), Positives = 123/293 (41%), Gaps = 43/293 (14%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY+I I+ N + LA + H P + LD F G+F FEA +KI+AL
Sbjct: 100 FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WNV D +VV+ G L GT + R RV+R +KL+S
Sbjct: 160 HKGSYLRNGWNVMDFVVVL-------TGILATVGTE-FDLRTLRAVRVLRPLKLVSGIPS 211
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQF----FGKVALDDSTSIHR------ 3843
++ +L + MK+ L + LL+ I+A+IG++F F ++ T +
Sbjct: 212 LQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAP 271
Query: 3844 -----------------------NN---NFHSFPAAILVLFRSATGEAWQDIMLSCSDRE 3945
NN F + A+L +F+ T E W D++ + +D
Sbjct: 272 CGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDAS 331
Query: 3946 DVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
GN + + YFI ++ SF ++NL + V+ F
Sbjct: 332 ---------------------GNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 363
Score = 75.1 bits (183), Expect = 2e-11
Identities = 72/337 (21%), Positives = 145/337 (42%), Gaps = 6/337 (1%)
Frame = +1
Query: 250 IVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIV 429
+V+ + F + +L ++ N + +AI ++ + L E++F+ +F E +K+
Sbjct: 483 MVKTQAFYWTVLSLVALNTLCVAIVH---YNQPEWLSDFLYYAEFIFLGLFMSEMFIKMY 539
Query: 430 AMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKALRAFRVLRPLRLV 603
+G Y +++N D V+IG + ++ + G F + LRA R+LR ++
Sbjct: 540 GLG----TRPYFHSSFNCFD-CGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVT 594
Query: 604 SGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ 783
SL+ ++ ++L +M ++ + L+ I+++A++G++LF GQ
Sbjct: 595 KYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLF------------GGQFNF 642
Query: 784 KDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQ 963
+ TP TNFD F A++TVFQ
Sbjct: 643 DEGTPP---------------------------------------TNFDTFPAAIMTVFQ 663
Query: 964 CVSLEGWTDVMY-WVNDAVGREWPW---IYFVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
++ E W +VMY + G + IYF+ L + G++ +LN+ L + + +E
Sbjct: 664 ILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQE- 722
Query: 1132 ARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVN 1242
K +Q EE+ + +A+++ V+
Sbjct: 723 ------LTKVEADEQEEEEAANQKLALQKAKEVAEVS 753
Score = 46.2 bits (108), Expect = 0.009
Identities = 50/264 (18%), Positives = 103/264 (38%), Gaps = 3/264 (1%)
Frame = +1
Query: 2293 AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN 2472
A +++K +S F R + +V F VL + +++ +A Q
Sbjct: 454 ARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPE 513
Query: 2473 STRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL 2652
+ L Y ++ F +F E+ +K+ G + ++FN D V+ S+ +
Sbjct: 514 WLSDF-LYYAEFIFLGLFMSEMFIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIW 568
Query: 2653 RTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
K L+++V ++ ++K+I +++ + F+ +F
Sbjct: 569 AVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
Query: 2824 AIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGD 3003
A++G+QLF G F ++++G P NFD
Sbjct: 629 ALLGMQLFGGQF-------------------NFDEGTPPT-------------NFDTFPA 656
Query: 3004 AMISLFVVSTFEGWPQLLYVAIDS 3075
A++++F + T E W +++Y I S
Sbjct: 657 AIMTVFQILTGEDWNEVMYDGIKS 680
>gi|2213911|gb|AAB61612.1| neuronal calcium channel alpha 1A subunit
isoform 1A-2 [Homo sapiens]
Length = 2266
Score = 668 bits (1724), Expect = 0.0
Identities = 405/1022 (39%), Positives = 570/1022 (55%), Gaps = 63/1022 (6%)
Frame = +1
Query: 2308 KPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNM 2487
KP+P SS+FILS TN R C+ ++N YF +L I +SS LAAEDP+Q N+ RN
Sbjct: 1219 KPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNN 1278
Query: 2488 ILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDA- 2664
+L YFDY FT VFT E+ +K+I GLV H+G++ R+ +N+LD +VV+ +L +F ++
Sbjct: 1279 VLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSK 1338
Query: 2665 ---MSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIG 2835
++ I R LK V CV+ ++K + NI++V + F+FA++
Sbjct: 1339 GKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVA 1398
Query: 2836 VQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMIS 3015
VQLFKG FF C D SK E +CRG+Y+ YE + ++ R W +F++DNV A+++
Sbjct: 1399 VQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVK---ARDREWKKYEFHYDNVLWALLT 1455
Query: 3016 LFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIV 3195
LF VST EGWPQ+L ++D+ E++GP R +++ +I+
Sbjct: 1456 LFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIII 1515
Query: 3196 TFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRAFEYVI 3369
TFQ +G++ E L+KN+R CI+FA+ AKP R++P+N+ QYR+W FV S FEY I
Sbjct: 1516 TFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTI 1575
Query: 3370 FLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNV 3549
+I +NT+ L K Y +S +E+ L VFN++FT +F+ E VLK++A NY D WN+
Sbjct: 1576 MAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNI 1635
Query: 3550 FDLLVVVGSFIDITYGKL-NPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKS 3726
FD + V+GS DI + NP N I+++F RLFR RL+KLL +G IR LLWTF++S
Sbjct: 1636 FDFVTVLGSITDILVTEFGNPN--NFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQS 1693
Query: 3727 FQALPYVALLIVLLFFIYAVIGMQFFGKVALD--------DSTSIHRNNNFHSFPAAILV 3882
F+ALPYV LLI +LFFIYA+IGMQ FG + +D D I +NNF +F A+++
Sbjct: 1694 FKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALML 1753
Query: 3883 LFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSF 4062
LFRSATGEAW +IMLSC + CD S G+ CGN FAY YF+SF LCSF
Sbjct: 1754 LFRSATGEAWHNIMLSCLSGKP--CDKNS------GILTRECGNEFAYFYFVSFIFLCSF 1805
Query: 4063 LVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKIS 4242
L++NLFVAVIMDNF+YLTRD SILGPHHL+E+VR+W+EYDP A GR+ +LD+ +LR +S
Sbjct: 1806 LMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAAWGRMPYLDMYQMLRHMS 1865
Query: 4243 PPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKI-YTEGNID--EAN 4413
PPLG GK CP R+A KRL+ M++P+ D TV FN+TL AL+RT L I +G D + +
Sbjct: 1866 PPLGLGKKCPARVAYKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMD 1925
Query: 4414 EQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRK------ 4575
+LR + IW + LD +V P K D+TVGK YA +I +Y+R+ K +K
Sbjct: 1926 AELRKEMMAIWPNLSQKTLDLLVTP-HKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAMRE 1984
Query: 4576 ----------EMEAKGVLPAQTPQAMALQA------GLRTLHEIGPE------LKRAISG 4689
ME P AL + G HE G + +RA
Sbjct: 1985 EQDRTPLMFQRMEPPSPTQEGGPGQNALPSTQLDPGGALMAHESGLKESPSWVTQRAQEM 2044
Query: 4690 NLETDFNFDEPEPQHRRPHSLFN--NLVHRLSGAGSKSPTEHERIEKGSTLLPFQPRSFS 4863
+T E P P+S N ++ R G S +EH +G PR +
Sbjct: 2045 FQKTGTWSPEQGPPTDMPNSQPNSQSVEMREMGRDGYSDSEHYLPMEGQGRAASMPRLPA 2104
Query: 4864 PTHSLAGAEGSPVPSQMHRGAPINQSINLPPVNGSARR-----LPALPPYANHIHDETDD 5028
G S + +P+ +S ++ + ARR L +PP N H +
Sbjct: 2105 ENQRRRGRPRGNNLSTISDTSPMKRSASV--LGPKARRLDDYSLERVPPEENQRHHQ--- 2159
Query: 5029 GPRYRDTGDRAGYDQSSRMVVANRNLPVD----------PDEEEQWMRSGGPSNRSDRRN 5178
R RD RA R + L D P +E R G P +R R++
Sbjct: 2160 --RRRDRSHRASERSLGRYTDVDTGLGTDLSMTTQSGDLPSKERDQER-GRPKDRKHRQH 2216
Query: 5179 PH 5184
H
Sbjct: 2217 HH 2218
Score = 536 bits (1381), Expect = e-150
Identities = 295/667 (44%), Positives = 383/667 (57%), Gaps = 27/667 (4%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N +RK I EW PFE++IL I ANCI LA+ Q P D + L+ E FI +
Sbjct: 84 DNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGI 143
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KI+A+GF FH +YLRN WN++DF++V+ G+++T+ ++ FD++ LRA R
Sbjct: 144 FCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE-----FDLRTLRAVR 198
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQVVL +I++AMIPLL I LL+ F ILI+AIIGLE + GK H+TC +
Sbjct: 199 VLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFE 258
Query: 760 PATGQLAQKDPTPCGTD----TEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNF 927
T + + P PCGT+ T + KCQP W GPNNGIT F
Sbjct: 259 EGTDDIQGESPAPCGTEEPARTCPNGTKCQPY-----------------WEGPNNGITQF 301
Query: 928 DNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSG 1107
DN A+LTVFQC+++EGWTD++Y NDA G W W+YF+ L+I+GSFF+LNLVLGVLSG
Sbjct: 302 DNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSG 361
Query: 1108 EFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVAQTXXX 1287
EF+KERE+ R F K R +QQ+E +L GY++WI++AE++ + EDE + E
Sbjct: 362 EFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEV-ILAEDETDGEQRHPFDGA 420
Query: 1288 XXXXXXXXXXXXXXXP-----------------SKWAARMKRLE------KLNXXXXXXX 1398
P ++ + + +LE K
Sbjct: 421 LRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFYI 480
Query: 1399 XXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYS 1578
+VK+Q FYW HY Q EWL F A F+ LF EM +KMY
Sbjct: 481 RRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYG 540
Query: 1579 LGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXX 1758
LG Y S FN FDC V+I SI E + G+SVLR+ RLLRIFKVTKYW
Sbjct: 541 LGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASL 600
Query: 1759 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQAL 1938
GMQ+FGG+FNF+ + P NFDTF A+
Sbjct: 601 RNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFD--EGTPPTNFDTFPAAI 658
Query: 1939 LTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNL 2118
+TVFQILTGEDWN VMY GI+S GGV G++ IY+IVL + GNY LLNVFLAIAVDNL
Sbjct: 659 MTVFQILTGEDWNEVMYDGIKSQGGVQG-GMVFSIYFIVLTLFGNYTLLNVFLAIAVDNL 717
Query: 2119 ADADSLT 2139
A+A LT
Sbjct: 718 ANAQELT 724
Score = 168 bits (425), Expect = 2e-39
Identities = 159/661 (24%), Positives = 279/661 (42%), Gaps = 30/661 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+R+LC I+ + FE IL +I + IALA P Q + +N +L +YVF VF
Sbjct: 1234 NPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDP--VQPNAPRNNVLRYFDYVFTGVF 1291
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD---VKALRA 573
T E V+K++ +G + H AY R+ WNILDFI+V LV+ + S +G D +K+LR
Sbjct: 1292 TFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNS-KGKDINTIKSLRV 1350
Query: 574 FRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTC 753
RVLRPL+ + +P L+ V + ++ ++ + +I ++ + + I+A++ ++LF GK C
Sbjct: 1351 LRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFH-C 1409
Query: 754 IDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDN 933
D + + +KD E + K + + W+ ++DN
Sbjct: 1410 TDES--KEFEKDCRGKYLLYEKNEVKARDRE--------WKKYE-----------FHYDN 1448
Query: 934 FGLAMLTVFQCVSLEGWTDVMYWVNDAV---------GREWPWIYFVTLVILGSFFVLNL 1086
A+LT+F + EGW V+ DA R I++V ++ FF +N+
Sbjct: 1449 VLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNI 1508
Query: 1087 VLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEP 1266
+ ++ F ++ + K E+ LE++ + +D+ A+ +
Sbjct: 1509 FVALIIITFQEQGD---------KMMEEYSLEKNERACIDFAISAKPL------------ 1547
Query: 1267 VAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXX 1446
+ + + V S F +
Sbjct: 1548 -----------------------------TRHMPQNKQSFQYRMWQFVVSPPFEYTIMAM 1578
Query: 1447 XXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDC 1626
+ YG S ++ + N+ F LFS+E +LK+ + G Y +N FD
Sbjct: 1579 IALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDF 1638
Query: 1627 FVVISSILEFVLVYF-DLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXX 1803
V+ SI + ++ F + + +S LR R R+ K+ +
Sbjct: 1639 VTVLGSITDILVTEFGNPNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALP 1698
Query: 1804 XXXXXXXXXXXXXXXXGMQVFGG--------KFNFNPQQPKPRANFDTFVQALLTVFQIL 1959
GMQVFG + + Q NF TF QAL+ +F+
Sbjct: 1699 YVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSA 1758
Query: 1960 TGEDWNTVMYHGI-----ESFGGVGT--LGVIVCIYYIV--LFICGNYILLNVFLAIAVD 2112
TGE W+ +M + + G+ T G +Y V +F+C ++++LN+F+A+ +D
Sbjct: 1759 TGEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMD 1817
Query: 2113 N 2115
N
Sbjct: 1818 N 1818
Score = 119 bits (299), Expect = 6e-25
Identities = 70/264 (26%), Positives = 135/264 (50%), Gaps = 1/264 (0%)
Frame = +1
Query: 3313 RLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEA 3492
R+++ + V ++AF + + ++ +NT+ +A HY DFL IF G+F E
Sbjct: 475 RMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEM 534
Query: 3493 VLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVK 3672
+K+ L + Y +N FD V++GS ++ + + PG + I+ R R++R+ K
Sbjct: 535 FIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTS--FGISVLRALRLLRIFK 592
Query: 3673 LLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNN 3849
+ +R L+ + + S +++ + L+ L ++A++GMQ F G+ D+ T
Sbjct: 593 VTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTP---PT 649
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FPAAI+ +F+ TGE W ++M + ++ +GG+ G
Sbjct: 650 NFDTFPAAIMTVFQILTGEDWNEVMY-----DGIK--------SQGGVQ----GGMVFSI 692
Query: 4030 YFISFFMLCSFLVINLFVAVIMDN 4101
YFI + ++ ++N+F+A+ +DN
Sbjct: 693 YFIVLTLFGNYTLLNVFLAIAVDN 716
Score = 91.3 bits (225), Expect = 2e-16
Identities = 73/298 (24%), Positives = 130/298 (43%), Gaps = 15/298 (5%)
Frame = +1
Query: 265 PFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFM 444
PFE+ I+ MI N I L + + Y+N L VF +F++ECVLK++A G +
Sbjct: 1570 PFEYTIMAMIALNTIVLMM--KFYGASVAYENAL-RVFNIVFTSLFSLECVLKVMAFGIL 1626
Query: 445 FHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKALRAFRVLRPLRLVSGVPS 618
Y R+AWNI DF+ V+ + ++++ ++ LR FR R ++L+ +
Sbjct: 1627 ----NYFRDAWNIFDFVTVLGSITDILVTEFGNPNNFINLSFLRLFRAARLIKLLRQGYT 1682
Query: 619 LQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTP 798
++++L +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1683 IRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF----------------------- 1719
Query: 799 CGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLE 978
N+G+ E + NF F A++ +F+ + E
Sbjct: 1720 ------------------GNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGE 1761
Query: 979 GWTDVMYWV--------NDAV-----GREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
W ++M N + G E+ + YFV+ + L SF +LNL + V+ F
Sbjct: 1762 AWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1819
Score = 86.7 bits (213), Expect = 6e-15
Identities = 70/263 (26%), Positives = 117/263 (43%), Gaps = 13/263 (4%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLF+ S N R + + F +L I+ + +LA E L + M L+
Sbjct: 77 SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSL-----TSFVLRTDAM 2667
+ +F +F E +K+I G FHKGS+ RN +N++D +VV + T F LRT
Sbjct: 137 EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRT--- 193
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
++ L+ V++ ++ A+ + I L+ F +FAIIG++ +
Sbjct: 194 -----LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFY 248
Query: 2848 KGTFFL------CNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAM 3009
G F +D+ + A C E + TK +N FDN+ A+
Sbjct: 249 MGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAV 308
Query: 3010 ISLFVVSTFEGWPQLLYVAIDSN 3078
+++F T EGW LLY + D++
Sbjct: 309 LTVFQCITMEGWTDLLYNSNDAS 331
Score = 80.9 bits (198), Expect = 3e-13
Identities = 75/293 (25%), Positives = 123/293 (41%), Gaps = 43/293 (14%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY+I I+ N + LA + H P + LD F G+F FEA +KI+AL
Sbjct: 100 FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WNV D +VV+ G L GT + R RV+R +KL+S
Sbjct: 160 HKGSYLRNGWNVMDFVVVL-------TGILATVGTE-FDLRTLRAVRVLRPLKLVSGIPS 211
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQF----FGKVALDDSTSIHR------ 3843
++ +L + MK+ L + LL+ I+A+IG++F F ++ T +
Sbjct: 212 LQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAP 271
Query: 3844 -----------------------NN---NFHSFPAAILVLFRSATGEAWQDIMLSCSDRE 3945
NN F + A+L +F+ T E W D++ + +D
Sbjct: 272 CGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDAS 331
Query: 3946 DVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
GN + + YFI ++ SF ++NL + V+ F
Sbjct: 332 ---------------------GNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 363
Score = 75.1 bits (183), Expect = 2e-11
Identities = 72/337 (21%), Positives = 145/337 (42%), Gaps = 6/337 (1%)
Frame = +1
Query: 250 IVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIV 429
+V+ + F + +L ++ N + +AI ++ + L E++F+ +F E +K+
Sbjct: 483 MVKTQAFYWTVLSLVALNTLCVAIVH---YNQPEWLSDFLYYAEFIFLGLFMSEMFIKMY 539
Query: 430 AMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKALRAFRVLRPLRLV 603
+G Y +++N D V+IG + ++ + G F + LRA R+LR ++
Sbjct: 540 GLG----TRPYFHSSFNCFD-CGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVT 594
Query: 604 SGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ 783
SL+ ++ ++L +M ++ + L+ I+++A++G++LF GQ
Sbjct: 595 KYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLF------------GGQFNF 642
Query: 784 KDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQ 963
+ TP TNFD F A++TVFQ
Sbjct: 643 DEGTPP---------------------------------------TNFDTFPAAIMTVFQ 663
Query: 964 CVSLEGWTDVMY-WVNDAVGREWPW---IYFVTLVILGSFFVLNLVLGVLSGEFSKEREK 1131
++ E W +VMY + G + IYF+ L + G++ +LN+ L + + +E
Sbjct: 664 ILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQE- 722
Query: 1132 ARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVN 1242
K +Q EE+ + +A+++ V+
Sbjct: 723 ------LTKVEADEQEEEEAANQKLALQKAKEVAEVS 753
Score = 46.2 bits (108), Expect = 0.009
Identities = 50/264 (18%), Positives = 103/264 (38%), Gaps = 3/264 (1%)
Frame = +1
Query: 2293 AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN 2472
A +++K +S F R + +V F VL + +++ +A Q
Sbjct: 454 ARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPE 513
Query: 2473 STRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL 2652
+ L Y ++ F +F E+ +K+ G + ++FN D V+ S+ +
Sbjct: 514 WLSDF-LYYAEFIFLGLFMSEMFIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIW 568
Query: 2653 RTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
K L+++V ++ ++K+I +++ + F+ +F
Sbjct: 569 AVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
Query: 2824 AIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGD 3003
A++G+QLF G F ++++G P NFD
Sbjct: 629 ALLGMQLFGGQF-------------------NFDEGTPPT-------------NFDTFPA 656
Query: 3004 AMISLFVVSTFEGWPQLLYVAIDS 3075
A++++F + T E W +++Y I S
Sbjct: 657 AIMTVFQILTGEDWNEVMYDGIKS 680
>gi|25453410|ref|NP_671482.1| calcium channel, voltage-dependent, N
type, alpha 1B subunit [Rattus norvegicus]
gi|3403207|gb|AAC29043.1| pore-forming calcium channel alpha-1B
subunit variant a [Rattus norvegicus]
Length = 2333
Score = 667 bits (1721), Expect = 0.0
Identities = 354/783 (45%), Positives = 492/783 (62%), Gaps = 11/783 (1%)
Frame = +1
Query: 2308 KPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNM 2487
+PI SS+F LS TN R FC+ +V YF +L I +SS LAAEDP++ +S RN
Sbjct: 1119 RPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEMVILVVIALSSIALAAEDPVRTDSFRNN 1178
Query: 2488 ILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL---RT 2658
L Y DY FT VFT E+ +K+I GL+ H G++ R+ +N+LD +VV+ +L +F +
Sbjct: 1179 ALKYMDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKG 1238
Query: 2659 DAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGV 2838
++ I R LK V CV+ ++K + NI++V + F+FA+I V
Sbjct: 1239 KDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAV 1298
Query: 2839 QLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISL 3018
QLFKG FF C D SK E +CRG+Y+ YE + ++ R W DF++DNV A+++L
Sbjct: 1299 QLFKGKFFYCTDESKELERDCRGQYLDYEKEEVE---AQPRQWKKYDFHYDNVLWALLTL 1355
Query: 3019 FVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIVT 3198
F VST EGWP +L ++D+ E++GP R +++ +I+T
Sbjct: 1356 FTVSTGEGWPMVLKHSVDATYEEQGPSPGFRMELSIFYVVYFVVFPFFFVNIFVALIIIT 1415
Query: 3199 FQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRAFEYVIF 3372
FQ +G++ C L+KN+R CI+FA+ AKP RY+P+N+ QY+ W FV S FEY I
Sbjct: 1416 FQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNKQSFQYKTWTFVVSPPFEYFIM 1475
Query: 3373 LIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVF 3552
+I +NTV L K Y + +E L N++FT +F+ E +LKI+A NY D WNVF
Sbjct: 1476 AMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSLECILKIIAFGVLNYFRDAWNVF 1535
Query: 3553 DLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQ 3732
D + V+GS DI ++ N I+++F RLFR RL+KLL +G IR LLWTF++SF+
Sbjct: 1536 DFVTVLGSITDILVTEIAETN-NFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFK 1594
Query: 3733 ALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAW 3912
ALPYV LLI +LFFIYA+IGMQ FG +ALDD TSI+R+NNF +F A+++LFRSATGEAW
Sbjct: 1595 ALPYVCLLIAMLFFIYAIIGMQVFGNIALDDGTSINRHNNFRTFLQALMLLFRSATGEAW 1654
Query: 3913 QDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVI 4092
+IMLSC CDP + N S CG++FAY YF+SF LCSFL++NLFVAVI
Sbjct: 1655 HEIMLSCLGNR--ACDPHA--------NASECGSDFAYFYFVSFIFLCSFLMLNLFVAVI 1704
Query: 4093 MDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCP 4272
MDNF+YLTRD SILGPHHL+EF+R+W+EYDP A GRI + D+ +L+ +SPPLG GK CP
Sbjct: 1705 MDNFEYLTRDSSILGPHHLDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCP 1764
Query: 4273 HRLACKRLVSMNMPL-NSDGTVCFNATLFALVRTNLKIY---TEGNIDEANEQLRSAIKR 4440
R+A KRLV MNMP+ N D TV F +TL AL+RT L+I + + +LR I
Sbjct: 1765 ARVAYKRLVRMNMPISNEDMTVHFTSTLMALIRTALEIKLAPAGTKQHQCDAELRKEISS 1824
Query: 4441 IWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEM--EAKGVLPAQTP 4614
+W + LD +VPP K D++TVGK YA +I D++++ K ++ +A G L P
Sbjct: 1825 VWANLPQKTLDLLVPP-HKPDEMTVGKVYAALMIFDFYKQNKTTRDQTHQAPGGLSQMGP 1883
Query: 4615 QAM 4623
++
Sbjct: 1884 VSL 1886
Score = 512 bits (1318), Expect = e-143
Identities = 293/664 (44%), Positives = 375/664 (56%), Gaps = 24/664 (3%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N +RK I EW PFE++IL I ANCI LA+ Q P D + L+ E FI +
Sbjct: 81 DNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGI 140
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KI+A+GF+FH +YLRN WN++DF++V+ G+++T + FD++ LRA R
Sbjct: 141 FCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTD-----FDLRTLRAVR 195
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQVVL +I++AM+PLL I LL+ F IL++AIIGLE + GK H C
Sbjct: 196 VLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFP 255
Query: 760 PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFG 939
+T D P G G + DS T EC WPGPN GITNFDN
Sbjct: 256 NST------DAEPVGDFPCGKEAPARLCDSDT------ECREY--WPGPNFGITNFDNIL 301
Query: 940 LAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSK 1119
A+LTVFQC+++EGWTD++Y NDA G W W+YF+ L+I+GSFF+LNLVLGVLSGEF+K
Sbjct: 302 FAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAK 361
Query: 1120 EREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPV-------AQT 1278
ERE+ R F K R +QQ+E +L GYL+WI +AE++ ED+ +E A T
Sbjct: 362 ERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDKNAEEKSPLDVLKRAAT 421
Query: 1279 XXXX-----------------XXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXL 1407
++ ++ +R EK+ +
Sbjct: 422 KKSRNDLIHAEEGEDRFVDLCAAGSPFARASLKSGKTESSSYFRRKEKM---FRFLIRRM 478
Query: 1408 VKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGF 1587
VK+Q+FYW HY Q + L A F+ LF EM LKMY LG
Sbjct: 479 VKAQSFYWVVLCVVALNTLCVAMVHYNQPQRLTTALYFAEFVFLGLFLTEMSLKMYGLGP 538
Query: 1588 TTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXX 1767
+Y S FN FD V++ SI E V G+SVLR+ RLLRIFKVTKYW
Sbjct: 539 RSYFRSSFNCFDFGVIVGSIFEVVWAAIKPGTSFGISVLRALRLLRIFKVTKYWNSLRNL 598
Query: 1768 XXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTV 1947
GMQ+FGG+FNF Q P NFDTF A+LTV
Sbjct: 599 VVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF--QDETPTTNFDTFPAAILTV 656
Query: 1948 FQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADA 2127
FQILTGEDWN VMYHGIES GGV + G+ Y+IVL + GNY LLNVFLAIAVDNLA+A
Sbjct: 657 FQILTGEDWNAVMYHGIESQGGV-SKGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANA 715
Query: 2128 DSLT 2139
LT
Sbjct: 716 QELT 719
Score = 134 bits (337), Expect = 3e-29
Identities = 92/322 (28%), Positives = 163/322 (50%), Gaps = 10/322 (3%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
N +R+ C IV + FE +IL +I + IALA P + ++N L+ ++Y+F VF
Sbjct: 1134 NLLRRFCHYIVTMRYFEMVILVVIALSSIALAAEDP--VRTDSFRNNALKYMDYIFTGVF 1191
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD-VKALRAFR 579
T E V+K++ +G + HP AY R+ WNILDFI+V LV+ S + + +K+LR R
Sbjct: 1192 TFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLR 1251
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF GK C D
Sbjct: 1252 VLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF-YCTD 1310
Query: 760 PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFG 939
+ + ++D D E + QP +W+ ++DN
Sbjct: 1311 ES--KELERDCRGQYLDYEKEEVEAQPR--------QWKKYD-----------FHYDNVL 1349
Query: 940 LAMLTVFQCVSLEGWTDVMYWVNDAVGREWP---------WIYFVTLVILGSFFVLNLVL 1092
A+LT+F + EGW V+ DA E I++V ++ FF +N+ +
Sbjct: 1350 WALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGFRMELSIFYVVYFVVFPFFFVNIFV 1409
Query: 1093 GVLSGEFSKEREKARARGLFQK 1158
++ F ++ +K + +K
Sbjct: 1410 ALIIITFQEQGDKVMSECSLEK 1431
Score = 122 bits (305), Expect = 1e-25
Identities = 75/269 (27%), Positives = 136/269 (49%), Gaps = 8/269 (2%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V +++F +V+ ++ +NT+ +A HY + L +F G+F E LK+ L P
Sbjct: 479 VKAQSFYWVVLCVVALNTLCVAMVHYNQPQRLTTALYFAEFVFLGLFLTEMSLKMYGLGP 538
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
++Y +N FD V+VGS ++ + + PG + I+ R R++R+ K+ +R
Sbjct: 539 RSYFRSSFNCFDFGVIVGSIFEVVWAAIKPGTS--FGISVLRALRLLRIFKVTKYWNSLR 596
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + + S +++ + L+ L ++A++GMQ F G+ D T NF +FPAAI
Sbjct: 597 NLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETP---TTNFDTFPAAI 653
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYH----KGGLNESRCGNNFAYPYFISF 4044
L +F+ TGE W +M YH +GG+++ F+ YFI
Sbjct: 654 LTVFQILTGEDWNAVM-----------------YHGIESQGGVSKGM----FSSFYFIVL 692
Query: 4045 FMLCSFLVINLFVAVIMDNF---DYLTRD 4122
+ ++ ++N+F+A+ +DN LT+D
Sbjct: 693 TLFGNYTLLNVFLAIAVDNLANAQELTKD 721
Score = 94.0 bits (232), Expect = 4e-17
Identities = 72/297 (24%), Positives = 134/297 (44%), Gaps = 14/297 (4%)
Frame = +1
Query: 265 PFEFLILFMICANCIALAIYQPYPAQDSDYKNTL-LETIEYVFIVVFTIECVLKIVAMGF 441
PFE+ I+ MI N + L + D+ Y+ L L+ + VF +F++EC+LKI+A G
Sbjct: 1469 PFEYFIMAMIALNTVVLMM----KFYDAPYEYELMLKCLNIVFTSMFSLECILKIIAFGV 1524
Query: 442 MFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKALRAFRVLRPLRLVSGVP 615
+ Y R+AWN+ DF+ V+ + ++++++ ++ LR FR R ++L+
Sbjct: 1525 L----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGY 1580
Query: 616 SLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPT 795
+++++L +++ L ++ LL+ + IYAIIG+++F G +A D T
Sbjct: 1581 TIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------GNIALDDGT 1627
Query: 796 PCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSL 975
N NF F A++ +F+ +
Sbjct: 1628 SI------------------------------------NRHNNFRTFLQALMLLFRSATG 1651
Query: 976 EGWTDVM-----------YWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
E W ++M + G ++ + YFV+ + L SF +LNL + V+ F
Sbjct: 1652 EAWHEIMLSCLGNRACDPHANASECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1708
Score = 90.9 bits (224), Expect = 3e-16
Identities = 72/262 (27%), Positives = 118/262 (44%), Gaps = 13/262 (4%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLF+ S N R + + F +L I+ + +LA E L M L+
Sbjct: 74 SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 133
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV-----AVSLTSFVLRTDAM 2667
+ +F +F E +K+I G VFHKGS+ RN +N++D +VV A + T F LRT
Sbjct: 134 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDFDLRT--- 190
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
++ L+ V++ ++ A+ + I L+ F MFAIIG++ +
Sbjct: 191 -----LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY 245
Query: 2848 KGTFFLCNDLSKMTEAECRGEYIHYEDGDP---TKPVSKKRVWSNNDF---NFDNVGDAM 3009
G F T+AE G++ ++ + W +F NFDN+ A+
Sbjct: 246 MGKFHKA-CFPNSTDAEPVGDFPCGKEAPARLCDSDTECREYWPGPNFGITNFDNILFAI 304
Query: 3010 ISLFVVSTFEGWPQLLYVAIDS 3075
+++F T EGW +LY D+
Sbjct: 305 LTVFQCITMEGWTDILYNTNDA 326
Score = 88.2 bits (217), Expect = 2e-15
Identities = 80/292 (27%), Positives = 127/292 (43%), Gaps = 42/292 (14%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY+I I+ N + LA + H P + LD F G+F FEA +KI+AL
Sbjct: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WNV D +VV+ G L GT+ + R RV+R +KL+S
Sbjct: 157 HKGSYLRNGWNVMDFVVVL-------TGILATAGTD-FDLRTLRAVRVLRPLKLVSGIPS 208
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF----------------------- 3804
++ +L + MK+ L + LL+ ++A+IG++F+
Sbjct: 209 LQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPC 268
Query: 3805 GKVA---LDDSTSIHRN---------NNFHSFPAAILVLFRSATGEAWQDIMLSCSDRED 3948
GK A L DS + R NF + AIL +F+ T E W DI+ + +D
Sbjct: 269 GKEAPARLCDSDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTND--- 325
Query: 3949 VRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
GN + + YFI ++ SF ++NL + V+ F
Sbjct: 326 ------------------AAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 359
Score = 70.1 bits (170), Expect = 6e-10
Identities = 92/480 (19%), Positives = 180/480 (37%), Gaps = 42/480 (8%)
Frame = +1
Query: 1534 FVILFSMEMLLKMYSLGFTTYTTSQF----NRFDCFVVISSILEFVLVYFDLMKPLGVSV 1701
F +F+ EM++KM LG + + F N D VV +++ F F K ++
Sbjct: 1187 FTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFA---FSGSKGKDINT 1243
Query: 1702 LRSARLLRIF---KVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGG 1872
++S R+LR+ K K +Q+F G
Sbjct: 1244 IKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKG 1303
Query: 1873 KFNFNPQQPK---------------------PRA------NFDTFVQALLTVFQILTGED 1971
KF + + K PR ++D + ALLT+F + TGE
Sbjct: 1304 KFFYCTDESKELERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEG 1363
Query: 1972 WNTVMYHGI----ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLT 2139
W V+ H + E G + + I+Y+V F+ + +N+F+A+ + +
Sbjct: 1364 WPMVLKHSVDATYEEQGPSPGFRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKV 1423
Query: 2140 NAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSARPRRMSEVPAASTVKPIP 2319
+ S + + A + KP+
Sbjct: 1424 MSE------------------------------------CSLEKNERACIDFAISAKPLT 1447
Query: 2320 KASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMILNY 2499
+ ++ + SF+ V F ++ I +++ +L + A ++L
Sbjct: 1448 R----YMPQNKQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKF-YDAPYEYELMLKC 1502
Query: 2500 FDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSF----VLRTDAM 2667
+ FTS+F++E LK+I FG++ ++ R+A+N+ D + V S+T + T+
Sbjct: 1503 LNIVFTSMFSLECILKIIAFGVL----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNF 1558
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
+ + ++ ++ + + K + + L+ ML F++AIIG+Q+F
Sbjct: 1559 INLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1618
Score = 70.1 bits (170), Expect = 6e-10
Identities = 51/205 (24%), Positives = 87/205 (41%), Gaps = 8/205 (3%)
Frame = +1
Query: 1525 NLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYF-DLMKPLGVSV 1701
N+ F +FS+E +LK+ + G Y +N FD V+ SI + ++ + + +S
Sbjct: 1504 NIVFTSMFSLECILKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSF 1563
Query: 1702 LRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFN 1881
LR R R+ K+ + GMQVFG
Sbjct: 1564 LRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIAL 1623
Query: 1882 FNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMY-----HGIESFGGVGTLGVIVCIY 2046
+ NF TF+QAL+ +F+ TGE W+ +M + G +
Sbjct: 1624 DDGTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLGNRACDPHANASECGSDFAYF 1683
Query: 2047 YIV--LFICGNYILLNVFLAIAVDN 2115
Y V +F+C ++++LN+F+A+ +DN
Sbjct: 1684 YFVSFIFLC-SFLMLNLFVAVIMDN 1707
Score = 54.7 bits (130), Expect = 3e-05
Identities = 55/264 (20%), Positives = 104/264 (38%), Gaps = 3/264 (1%)
Frame = +1
Query: 2293 AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN 2472
A +++K SS + FR +V F VL C++ + + A
Sbjct: 449 ARASLKSGKTESSSYFRRKEKMFRFLIRRMVKAQSFYWVVL-CVVALNTLCVAMVHYNQP 507
Query: 2473 STRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL 2652
L + ++ F +F E++LK+ G S+ R++FN D V+ S+ V
Sbjct: 508 QRLTTALYFAEFVFLGLFLTEMSLKMYGLG----PRSYFRSSFNCFDFGVIVGSIFEVVW 563
Query: 2653 RTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
K L+++V ++ ++K+I +++ + F+ +F
Sbjct: 564 AAIKPGTSFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVF 623
Query: 2824 AIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGD 3003
A++G+QLF G F +++D PT NFD
Sbjct: 624 ALLGMQLFGGQF-------------------NFQDETPTT-------------NFDTFPA 651
Query: 3004 AMISLFVVSTFEGWPQLLYVAIDS 3075
A++++F + T E W ++Y I+S
Sbjct: 652 AILTVFQILTGEDWNAVMYHGIES 675
>gi|7630181|dbj|BAA94765.1| alpha1A-voltage-dependent calcium channel
[Homo sapiens]
Length = 2472
Score = 667 bits (1721), Expect = 0.0
Identities = 404/1021 (39%), Positives = 568/1021 (55%), Gaps = 62/1021 (6%)
Frame = +1
Query: 2308 KPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNM 2487
KP+P SS+FILS TN R C+ ++N YF +L I +SS LAAEDP+Q N+ RN
Sbjct: 1216 KPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNN 1275
Query: 2488 ILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDA- 2664
+L YFDY FT VFT E+ +K+I GLV H+G++ R+ +N+LD +VV+ +L +F ++
Sbjct: 1276 VLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSK 1335
Query: 2665 ---MSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIG 2835
++ I R LK V CV+ ++K + NI++V + F+FA++
Sbjct: 1336 GKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVA 1395
Query: 2836 VQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMIS 3015
VQLFKG FF C D SK E +CRG+Y+ YE + ++ R W +F++DNV A+++
Sbjct: 1396 VQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVK---ARDREWKKYEFHYDNVLWALLT 1452
Query: 3016 LFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIV 3195
LF VST EGWPQ+L ++D+ E++GP R +++ +I+
Sbjct: 1453 LFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIII 1512
Query: 3196 TFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRAFEYVI 3369
TFQ +G++ E L+KN+R CI+FA+ AKP R++P+N+ QYR+W FV S FEY I
Sbjct: 1513 TFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTI 1572
Query: 3370 FLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNV 3549
+I +NT+ L K Y +S +E+ L VFN++FT +F+ E VLK++A NY D WN+
Sbjct: 1573 MAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNI 1632
Query: 3550 FDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSF 3729
FD + V+GS DI + G N I+++F RLFR RL+KLL +G IR LLWTF++SF
Sbjct: 1633 FDFVTVLGSITDILVTEF---GNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSF 1689
Query: 3730 QALPYVALLIVLLFFIYAVIGMQFFGKVALD--------DSTSIHRNNNFHSFPAAILVL 3885
+ALPYV LLI +LFFIYA+IGMQ FG + +D D I +NNF +F A+++L
Sbjct: 1690 KALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLL 1749
Query: 3886 FRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFL 4065
FRSATGEAW +IMLSC + CD S G+ CGN FAY YF+SF LCSFL
Sbjct: 1750 FRSATGEAWHNIMLSCLSGKP--CDKNS------GILTRECGNEFAYFYFVSFIFLCSFL 1801
Query: 4066 VINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISP 4245
++NLFVAVIMDNF+YLTRD SILGPHHL+E+VR+W+EYDP A GRI + D+ +LLR +SP
Sbjct: 1802 MLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAACGRIHYKDMYSLLRVMSP 1861
Query: 4246 PLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKI-YTEGNID--EANE 4416
PLG GK CP +A KRL+ M++P+ D TV FN+TL AL+RT L I +G D + +
Sbjct: 1862 PLGLGKKCPPGVAYKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDA 1921
Query: 4417 QLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRK------- 4575
+LR + IW + LD +V P K D+TVGK YA +I +Y+R+ K +K
Sbjct: 1922 ELRKEMMAIWPNLSQKTLDLLVTP-HKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAMREE 1980
Query: 4576 ---------EMEAKGVLPAQTPQAMALQA------GLRTLHEIGPE------LKRAISGN 4692
ME P AL + G HE G + +RA
Sbjct: 1981 QDRTPLMFQRMEPPSPTQEGGPGQNALPSTQLDPGGALMAHESGLKESPSWVTQRAQEMF 2040
Query: 4693 LETDFNFDEPEPQHRRPHSLFN--NLVHRLSGAGSKSPTEHERIEKGSTLLPFQPRSFSP 4866
+T E P P+S N ++ R G S +EH +G PR +
Sbjct: 2041 QKTGTWSPEQGPPTDMPNSQPNSQSVEMREMGRDGYSDSEHYLPMEGQGRAASMPRLPAE 2100
Query: 4867 THSLAGAEGSPVPSQMHRGAPINQSINLPPVNGSARR-----LPALPPYANHIHDETDDG 5031
G S + +P+ +S ++ + ARR L +PP N H +
Sbjct: 2101 NQRRRGRPRGNNLSTISDTSPMKRSASV--LGPKARRLDDYSLERVPPEENQRHHQ---- 2154
Query: 5032 PRYRDTGDRAGYDQSSRMVVANRNLPVD----------PDEEEQWMRSGGPSNRSDRRNP 5181
R RD RA R + L D P +E R G P +R R++
Sbjct: 2155 -RRRDRSHRASERSLGRYTDVDTGLGTDLSMTTQSGDLPSKERDQER-GRPKDRKHRQHH 2212
Query: 5182 H 5184
H
Sbjct: 2213 H 2213
Score = 529 bits (1363), Expect = e-148
Identities = 293/667 (43%), Positives = 380/667 (56%), Gaps = 27/667 (4%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N +RK I EW PFE++IL I ANCI LA+ Q P D + L+ E FI +
Sbjct: 84 DNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGI 143
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KI+A+GF FH +YLRN WN++DF++V+ G+++T+ ++ FD++ LRA R
Sbjct: 144 FCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE-----FDLRTLRAVR 198
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQVVL +I++AMIPLL I LL+ F ILI+AIIGLE + GK H+TC +
Sbjct: 199 VLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFE 258
Query: 760 PATGQLAQKDPTPCGTD----TEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNF 927
T + + P PCGT+ T + KCQP W GPNNGIT F
Sbjct: 259 EGTDDIQGESPAPCGTEEPARTCPNGTKCQPY-----------------WEGPNNGITQF 301
Query: 928 DNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSG 1107
DN A+LTVFQC+++EGWTD++Y NDA G W W+YF+ L+I+GSFF+LNLVLGVLSG
Sbjct: 302 DNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSG 361
Query: 1108 EFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVAQTXXX 1287
EF+KERE+ R F K R +QQ+E +L GY++WI++AE++ + EDE + E
Sbjct: 362 EFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEV-ILAEDETDGEQRHPFDGA 420
Query: 1288 XXXXXXXXXXXXXXXP-----------------SKWAARMKRLE------KLNXXXXXXX 1398
P ++ + + +LE K
Sbjct: 421 LRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSTKLENSTFFHKKERRMRFYI 480
Query: 1399 XXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYS 1578
+VK+Q FYW HY Q EWL F A F+ LF EM +KMY
Sbjct: 481 RRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYG 540
Query: 1579 LGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXX 1758
LG Y S FN FDC V+I SI E + G+SVLR+ RLLRIFKVTKYW
Sbjct: 541 LGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASL 600
Query: 1759 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQAL 1938
GMQ+FGG+FNF+ + P NFDTF A
Sbjct: 601 RNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFD--EGTPPTNFDTFPAAR 658
Query: 1939 LTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNL 2118
+TVFQ LTGEDWN VMY GI+S GGV G++ IY+IVL + GNY LLNVFLAIAVDNL
Sbjct: 659 MTVFQSLTGEDWNEVMYDGIKSQGGVQG-GMVFSIYFIVLTLFGNYTLLNVFLAIAVDNL 717
Query: 2119 ADADSLT 2139
A+ LT
Sbjct: 718 ANVLELT 724
Score = 168 bits (426), Expect = 1e-39
Identities = 159/660 (24%), Positives = 278/660 (42%), Gaps = 29/660 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+R+LC I+ + FE IL +I + IALA P Q + +N +L +YVF VF
Sbjct: 1231 NPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDP--VQPNAPRNNVLRYFDYVFTGVF 1288
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD---VKALRA 573
T E V+K++ +G + H AY R+ WNILDFI+V LV+ + S +G D +K+LR
Sbjct: 1289 TFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNS-KGKDINTIKSLRV 1347
Query: 574 FRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTC 753
RVLRPL+ + +P L+ V + ++ ++ + +I ++ + + I+A++ ++LF GK C
Sbjct: 1348 LRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFH-C 1406
Query: 754 IDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDN 933
D + + +KD E + K + + W+ ++DN
Sbjct: 1407 TDES--KEFEKDCRGKYLLYEKNEVKARDRE--------WKKYE-----------FHYDN 1445
Query: 934 FGLAMLTVFQCVSLEGWTDVMYWVNDAV---------GREWPWIYFVTLVILGSFFVLNL 1086
A+LT+F + EGW V+ DA R I++V ++ FF +N+
Sbjct: 1446 VLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNI 1505
Query: 1087 VLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEP 1266
+ ++ F ++ + K E+ LE++ + +D+ A+ +
Sbjct: 1506 FVALIIITFQEQGD---------KMMEEYSLEKNERACIDFAISAKPL------------ 1544
Query: 1267 VAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXX 1446
+ + + V S F +
Sbjct: 1545 -----------------------------TRHMPQNKQSFQYRMWQFVVSPPFEYTIMAM 1575
Query: 1447 XXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDC 1626
+ YG S ++ + N+ F LFS+E +LK+ + G Y +N FD
Sbjct: 1576 IALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDF 1635
Query: 1627 FVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXX 1806
V+ SI + ++ F + +S LR R R+ K+ +
Sbjct: 1636 VTVLGSITDILVTEFG-NNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPY 1694
Query: 1807 XXXXXXXXXXXXXXXGMQVFGG--------KFNFNPQQPKPRANFDTFVQALLTVFQILT 1962
GMQVFG + + Q NF TF QAL+ +F+ T
Sbjct: 1695 VCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSAT 1754
Query: 1963 GEDWNTVMYHGI-----ESFGGVGT--LGVIVCIYYIV--LFICGNYILLNVFLAIAVDN 2115
GE W+ +M + + G+ T G +Y V +F+C ++++LN+F+A+ +DN
Sbjct: 1755 GEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1813
Score = 119 bits (298), Expect = 8e-25
Identities = 70/264 (26%), Positives = 135/264 (50%), Gaps = 1/264 (0%)
Frame = +1
Query: 3313 RLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEA 3492
R+++ + V ++AF + + ++ +NT+ +A HY DFL IF G+F E
Sbjct: 475 RMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEM 534
Query: 3493 VLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVK 3672
+K+ L + Y +N FD V++GS ++ + + PG + I+ R R++R+ K
Sbjct: 535 FIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTS--FGISVLRALRLLRIFK 592
Query: 3673 LLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNN 3849
+ +R L+ + + S +++ + L+ L ++A++GMQ F G+ D+ T
Sbjct: 593 VTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTP---PT 649
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FPAA + +F+S TGE W ++M + ++ +GG+ G
Sbjct: 650 NFDTFPAARMTVFQSLTGEDWNEVMY-----DGIK--------SQGGVQ----GGMVFSI 692
Query: 4030 YFISFFMLCSFLVINLFVAVIMDN 4101
YFI + ++ ++N+F+A+ +DN
Sbjct: 693 YFIVLTLFGNYTLLNVFLAIAVDN 716
Score = 95.5 bits (236), Expect = 1e-17
Identities = 73/296 (24%), Positives = 130/296 (43%), Gaps = 13/296 (4%)
Frame = +1
Query: 265 PFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFM 444
PFE+ I+ MI N I L + + Y+N L VF +F++ECVLK++A G +
Sbjct: 1567 PFEYTIMAMIALNTIVLMM--KFYGASVAYENAL-RVFNIVFTSLFSLECVLKVMAFGIL 1623
Query: 445 FHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQ 624
Y R+AWNI DF+ V+ + ++++ ++ LR FR R ++L+ +++
Sbjct: 1624 ----NYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIR 1679
Query: 625 VVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCG 804
++L +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1680 ILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF------------------------- 1714
Query: 805 TDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGW 984
N+G+ E + NF F A++ +F+ + E W
Sbjct: 1715 ----------------GNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAW 1758
Query: 985 TDVMYWV--------NDAV-----GREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
++M N + G E+ + YFV+ + L SF +LNL + V+ F
Sbjct: 1759 HNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1814
Score = 86.7 bits (213), Expect = 6e-15
Identities = 70/263 (26%), Positives = 117/263 (43%), Gaps = 13/263 (4%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLF+ S N R + + F +L I+ + +LA E L + M L+
Sbjct: 77 SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSL-----TSFVLRTDAM 2667
+ +F +F E +K+I G FHKGS+ RN +N++D +VV + T F LRT
Sbjct: 137 EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRT--- 193
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
++ L+ V++ ++ A+ + I L+ F +FAIIG++ +
Sbjct: 194 -----LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFY 248
Query: 2848 KGTFFL------CNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAM 3009
G F +D+ + A C E + TK +N FDN+ A+
Sbjct: 249 MGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAV 308
Query: 3010 ISLFVVSTFEGWPQLLYVAIDSN 3078
+++F T EGW LLY + D++
Sbjct: 309 LTVFQCITMEGWTDLLYNSNDAS 331
Score = 80.9 bits (198), Expect = 3e-13
Identities = 75/293 (25%), Positives = 123/293 (41%), Gaps = 43/293 (14%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY+I I+ N + LA + H P + LD F G+F FEA +KI+AL
Sbjct: 100 FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WNV D +VV+ G L GT + R RV+R +KL+S
Sbjct: 160 HKGSYLRNGWNVMDFVVVL-------TGILATVGTE-FDLRTLRAVRVLRPLKLVSGIPS 211
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQF----FGKVALDDSTSIHR------ 3843
++ +L + MK+ L + LL+ I+A+IG++F F ++ T +
Sbjct: 212 LQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAP 271
Query: 3844 -----------------------NN---NFHSFPAAILVLFRSATGEAWQDIMLSCSDRE 3945
NN F + A+L +F+ T E W D++ + +D
Sbjct: 272 CGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDAS 331
Query: 3946 DVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
GN + + YFI ++ SF ++NL + V+ F
Sbjct: 332 ---------------------GNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 363
Score = 75.1 bits (183), Expect = 2e-11
Identities = 72/322 (22%), Positives = 139/322 (42%), Gaps = 16/322 (4%)
Frame = +1
Query: 250 IVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIV 429
+V+ + F + +L ++ N + +AI ++ + L E++F+ +F E +K+
Sbjct: 483 MVKTQAFYWTVLSLVALNTLCVAIVH---YNQPEWLSDFLYYAEFIFLGLFMSEMFIKMY 539
Query: 430 AMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKALRAFRVLRPLRLV 603
+G Y +++N D V+IG + ++ + G F + LRA R+LR ++
Sbjct: 540 GLG----TRPYFHSSFNCFD-CGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVT 594
Query: 604 SGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ 783
SL+ ++ ++L +M ++ + L+ I+++A++G++LF GQ
Sbjct: 595 KYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLF------------GGQFNF 642
Query: 784 KDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQ 963
+ TP TNFD F A +TVFQ
Sbjct: 643 DEGTPP---------------------------------------TNFDTFPAARMTVFQ 663
Query: 964 CVSLEGWTDVMY-WVNDAVGREWPW---IYFVTLVILGSFFVLNLVLGV----------L 1101
++ E W +VMY + G + IYF+ L + G++ +LN+ L + L
Sbjct: 664 SLTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANVLEL 723
Query: 1102 SGEFSKEREKARARGLFQKFRE 1167
+ + +E E A + QK +E
Sbjct: 724 TKDEQEEEEAANQKLALQKAKE 745
Score = 43.5 bits (101), Expect = 0.059
Identities = 50/264 (18%), Positives = 101/264 (37%), Gaps = 3/264 (1%)
Frame = +1
Query: 2293 AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN 2472
A +++K +S F R + +V F VL + +++ +A Q
Sbjct: 454 ARASIKSTKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPE 513
Query: 2473 STRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL 2652
+ L Y ++ F +F E+ +K+ G + ++FN D V+ S+ +
Sbjct: 514 WLSDF-LYYAEFIFLGLFMSEMFIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIW 568
Query: 2653 RTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
K L+++V ++ ++K+I +++ + F+ +F
Sbjct: 569 AVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
Query: 2824 AIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGD 3003
A++G+QLF G F ++++G P NFD
Sbjct: 629 ALLGMQLFGGQF-------------------NFDEGTPPT-------------NFDTFPA 656
Query: 3004 AMISLFVVSTFEGWPQLLYVAIDS 3075
A +++F T E W +++Y I S
Sbjct: 657 ARMTVFQSLTGEDWNEVMYDGIKS 680
>gi|6166049|sp|O55017|CCAB_MOUSE Voltage-dependent N-type calcium
channel alpha-1B subunit (Voltage-gated calcium channel
alpha subunit Cav2.2) (Calcium channel, L type, alpha-1
polypeptide isoform 5) (Brain calcium channel III) (BIII)
gi|2811218|gb|AAB97840.1| neuronal type calcium channel alpha-1
subunit [Mus musculus]
Length = 2327
Score = 667 bits (1720), Expect = 0.0
Identities = 354/787 (44%), Positives = 492/787 (61%), Gaps = 15/787 (1%)
Frame = +1
Query: 2308 KPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNM 2487
+PI SS+F LS TN R FC+ +V YF +L I +SS LAAEDP++ +S RN
Sbjct: 1111 RPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEMVILVVIALSSIALAAEDPVRTDSFRNN 1170
Query: 2488 ILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRT--- 2658
L Y DY FT VFT E+ +K+I GL+ H G++ R+ +N+LD +VV+ +L +F +
Sbjct: 1171 ALKYMDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSSFMG 1230
Query: 2659 ----DAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFA 2826
++ I R LK V CV+ ++K + NI++V + F+FA
Sbjct: 1231 GSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFA 1290
Query: 2827 IIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDA 3006
+I VQLFKG FF C D SK E +CRG+Y+ YE + ++ R W DF++DNV A
Sbjct: 1291 VIAVQLFKGKFFYCTDESKELERDCRGQYLDYEKEEVE---AQPRQWKKYDFHYDNVLWA 1347
Query: 3007 MISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGF 3186
+++LF VST EGWP +L ++D+ E++GP R +++
Sbjct: 1348 LLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGFRMELSIFYVVYFVVFPFFFVNIFVAL 1407
Query: 3187 VIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRAFE 3360
+I+TFQ +G++ C L+KN+R CI+FA+ AKP RY+P+N+ QY+ W FV S FE
Sbjct: 1408 IIITFQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNKQSFQYKTWTFVVSPPFE 1467
Query: 3361 YVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDR 3540
Y I +I +NTV L K Y + +E L N++FT +F+ E +LKI+A NY D
Sbjct: 1468 YFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECILKIIAFGVLNYFRDA 1527
Query: 3541 WNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFM 3720
WNVFD + V+GS DI ++ N I+++F RLFR RL+KLL +G IR LLWTF+
Sbjct: 1528 WNVFDFVTVLGSITDILVTEI---ANNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFV 1584
Query: 3721 KSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSAT 3900
+SF+ALPYV LLI +LFFIYA+IGMQ FG +ALDD TSI+R+NNF +F A+++LFRSAT
Sbjct: 1585 QSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSAT 1644
Query: 3901 GEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLF 4080
GEAW +IMLSC CDP + N S CG++FAY YF+SF LCSFL++NLF
Sbjct: 1645 GEAWHEIMLSCLGNR--ACDPHA--------NASECGSDFAYFYFVSFIFLCSFLMLNLF 1694
Query: 4081 VAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFG 4260
VAVIMDNF+YLTRD SILGPHHL+EF+R+W+EYDP A GRI + D+ +L+ +SPPLG G
Sbjct: 1695 VAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLG 1754
Query: 4261 KLCPHRLACKRLVSMNMPL-NSDGTVCFNATLFALVRTNLKIY---TEGNIDEANEQLRS 4428
K CP R+A KRLV MNMP+ N D TV F +TL AL+RT L+I + + +LR
Sbjct: 1755 KKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALIRTALEIKLAPAGTKQHQCDAELRK 1814
Query: 4429 AIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEM--EAKGVLP 4602
I +W + LD +VPP K D++TVGK YA +I D++++ K ++ +A G L
Sbjct: 1815 EISSVWANLPQKTLDLLVPP-HKPDEMTVGKVYAALMIFDFYKQNKTTRDQTHQAPGGLS 1873
Query: 4603 AQTPQAM 4623
P ++
Sbjct: 1874 QMGPVSL 1880
Score = 511 bits (1317), Expect = e-143
Identities = 291/664 (43%), Positives = 373/664 (55%), Gaps = 24/664 (3%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N +RK I EW PFE++IL I ANCI LA+ Q P D + L+ E FI +
Sbjct: 81 DNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGI 140
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KI+A+GF+FH +YLRN WN++DF++V+ G+++T + FD++ LRA R
Sbjct: 141 FCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTD-----FDLRTLRAVR 195
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQVVL +I++AM+PLL I LL+ F IL++AIIGLE + GK H C
Sbjct: 196 VLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFP 255
Query: 760 PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFG 939
+T D PCG D A +C EC WPGPN GITNFDN
Sbjct: 256 NSTDTEPVGD-FPCGKDPP--ARQCDGDT---------ECREY--WPGPNFGITNFDNIL 301
Query: 940 LAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSK 1119
A+LTVFQC+++EGWTD++Y NDA G W W+YF+ L+I+GSFF+LNLVLGVLSGEF+K
Sbjct: 302 FAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAK 361
Query: 1120 EREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVAQTXXXXXXX 1299
ERE+ R F K R +QQ+E +L GYL+WI +AE++ ED+ +E
Sbjct: 362 ERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDKNAEEKSPLDVLKRAAT 421
Query: 1300 XXX------------------------XXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXL 1407
++ ++ +R EK+ +
Sbjct: 422 KKSRNDLIHAEEGEDRFVDLCAVGSPFARASLKSGKTESSSYFRRKEKM---FRFFIRRM 478
Query: 1408 VKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGF 1587
VK+Q+FYW HY Q + L A F+ LF EM LKMY LG
Sbjct: 479 VKAQSFYWVVLCVVALNTLCVAMVHYNQPQRLTTALYFAEFVFLGLFLTEMSLKMYGLGP 538
Query: 1588 TTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXX 1767
+Y S FN FD V++ SI E V G+SVLR+ RLLRIFKVTKYW
Sbjct: 539 RSYFRSSFNCFDFGVIVGSIFEVVWAAIKPGTSFGISVLRALRLLRIFKVTKYWNSLRNL 598
Query: 1768 XXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTV 1947
GMQ+FGG+FNF Q P NFDTF A+LTV
Sbjct: 599 VVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF--QDETPTTNFDTFPAAILTV 656
Query: 1948 FQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADA 2127
FQILTGEDWN VMYHGIES GGV + G+ Y+IVL + GNY LLNVFLAIAVDNLA+A
Sbjct: 657 FQILTGEDWNAVMYHGIESQGGV-SKGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANA 715
Query: 2128 DSLT 2139
LT
Sbjct: 716 QELT 719
Score = 134 bits (336), Expect = 3e-29
Identities = 94/326 (28%), Positives = 164/326 (49%), Gaps = 14/326 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
N +R+ C IV + FE +IL +I + IALA P + ++N L+ ++Y+F VF
Sbjct: 1126 NLLRRFCHYIVTMRYFEMVILVVIALSSIALAAEDP--VRTDSFRNNALKYMDYIFTGVF 1183
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKM--SIQGFD---VKAL 567
T E V+K++ +G + HP AY R+ WNILDFI+V LV+ S +G D +K+L
Sbjct: 1184 TFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSSFMGGSKGKDINTIKSL 1243
Query: 568 RAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHS 747
R RVLRPL+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF GK
Sbjct: 1244 RVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF- 1302
Query: 748 TCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNF 927
C D + + ++D D E + QP +W+ ++
Sbjct: 1303 YCTDES--KELERDCRGQYLDYEKEEVEAQPR--------QWKKYD-----------FHY 1341
Query: 928 DNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWP---------WIYFVTLVILGSFFVL 1080
DN A+LT+F + EGW V+ DA E I++V ++ FF +
Sbjct: 1342 DNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGFRMELSIFYVVYFVVFPFFFV 1401
Query: 1081 NLVLGVLSGEFSKEREKARARGLFQK 1158
N+ + ++ F ++ +K + +K
Sbjct: 1402 NIFVALIIITFQEQGDKVMSECSLEK 1427
Score = 122 bits (306), Expect = 1e-25
Identities = 81/293 (27%), Positives = 143/293 (48%), Gaps = 8/293 (2%)
Frame = +1
Query: 3268 FALKAKPHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFL 3447
F K K R +I R V +++F +V+ ++ +NT+ +A HY + L
Sbjct: 464 FRRKEKMFRFFIRR---------MVKAQSFYWVVLCVVALNTLCVAMVHYNQPQRLTTAL 514
Query: 3448 DVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLI 3627
+F G+F E LK+ L P++Y +N FD V+VGS ++ + + PG +
Sbjct: 515 YFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSIFEVVWAAIKPGTS--F 572
Query: 3628 SINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF- 3804
I+ R R++R+ K+ +R L+ + + S +++ + L+ L ++A++GMQ F
Sbjct: 573 GISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFG 632
Query: 3805 GKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYH- 3981
G+ D T NF +FPAAIL +F+ TGE W +M YH
Sbjct: 633 GQFNFQDETP---TTNFDTFPAAILTVFQILTGEDWNAVM-----------------YHG 672
Query: 3982 ---KGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF---DYLTRD 4122
+GG+++ F+ YFI + ++ ++N+F+A+ +DN LT+D
Sbjct: 673 IESQGGVSKGM----FSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 721
Score = 98.2 bits (243), Expect = 2e-18
Identities = 72/295 (24%), Positives = 134/295 (45%), Gaps = 12/295 (4%)
Frame = +1
Query: 265 PFEFLILFMICANCIALAIYQPYPAQDSDYKNTL-LETIEYVFIVVFTIECVLKIVAMGF 441
PFE+ I+ MI N + L + D+ Y+ L L+ + VF +F++EC+LKI+A G
Sbjct: 1465 PFEYFIMAMIALNTVVLMM----KFYDAPYEYELMLKCLNIVFTSMFSMECILKIIAFGV 1520
Query: 442 MFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSL 621
+ Y R+AWN+ DF+ V+ + ++++++ ++ LR FR R ++L+ ++
Sbjct: 1521 L----NYFRDAWNVFDFVTVLGSITDILVTEIANNFINLSFLRLFRAARLIKLLRQGYTI 1576
Query: 622 QVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPC 801
+++L +++ L ++ LL+ + IYAIIG+++F G +A D T
Sbjct: 1577 RILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------GNIALDDDTSI 1623
Query: 802 GTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEG 981
N NF F A++ +F+ + E
Sbjct: 1624 ------------------------------------NRHNNFRTFLQALMLLFRSATGEA 1647
Query: 982 WTDVM-----------YWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
W ++M + G ++ + YFV+ + L SF +LNL + V+ F
Sbjct: 1648 WHEIMLSCLGNRACDPHANASECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1702
Score = 90.5 bits (223), Expect = 4e-16
Identities = 72/262 (27%), Positives = 118/262 (44%), Gaps = 13/262 (4%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLF+ S N R + + F +L I+ + +LA E L M L+
Sbjct: 74 SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 133
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV-----AVSLTSFVLRTDAM 2667
+ +F +F E +K+I G VFHKGS+ RN +N++D +VV A + T F LRT
Sbjct: 134 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDFDLRT--- 190
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
++ L+ V++ ++ A+ + I L+ F MFAIIG++ +
Sbjct: 191 -----LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY 245
Query: 2848 KGTFFLCNDLSKMTEAECRGEYIHYEDGDPTK---PVSKKRVWSNNDF---NFDNVGDAM 3009
G F T+ E G++ +D + + W +F NFDN+ A+
Sbjct: 246 MGKFHKA-CFPNSTDTEPVGDFPCGKDPPARQCDGDTECREYWPGPNFGITNFDNILFAI 304
Query: 3010 ISLFVVSTFEGWPQLLYVAIDS 3075
+++F T EGW +LY D+
Sbjct: 305 LTVFQCITMEGWTDILYNTNDA 326
Score = 87.0 bits (214), Expect = 5e-15
Identities = 77/292 (26%), Positives = 123/292 (41%), Gaps = 42/292 (14%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY+I I+ N + LA + H P + LD F G+F FEA +KI+AL
Sbjct: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WNV D +VV+ G L GT+ + R RV+R +KL+S
Sbjct: 157 HKGSYLRNGWNVMDFVVVL-------TGILATAGTD-FDLRTLRAVRVLRPLKLVSGIPS 208
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQF----FGKVALDDSTSIH------- 3840
++ +L + MK+ L + LL+ ++A+IG++F F K +ST
Sbjct: 209 LQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDTEPVGDFPC 268
Query: 3841 ------------------------RNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDRED 3948
NF + AIL +F+ T E W DI+ + +D
Sbjct: 269 GKDPPARQCDGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTND--- 325
Query: 3949 VRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
GN + + YFI ++ SF ++NL + V+ F
Sbjct: 326 ------------------AAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 359
Score = 72.0 bits (175), Expect = 2e-10
Identities = 54/204 (26%), Positives = 87/204 (42%), Gaps = 7/204 (3%)
Frame = +1
Query: 1525 NLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVL 1704
N+ F +FSME +LK+ + G Y +N FD V+ SI + +LV + +S L
Sbjct: 1500 NIVFTSMFSMECILKIIAFGVLNYFRDAWNVFDFVTVLGSITD-ILVTEIANNFINLSFL 1558
Query: 1705 RSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNF 1884
R R R+ K+ + GMQVFG
Sbjct: 1559 RLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALD 1618
Query: 1885 NPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMY-----HGIESFGGVGTLGVIVCIYY 2049
+ NF TF+QAL+ +F+ TGE W+ +M + G +Y
Sbjct: 1619 DDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLGNRACDPHANASECGSDFAYFY 1678
Query: 2050 IV--LFICGNYILLNVFLAIAVDN 2115
V +F+C ++++LN+F+A+ +DN
Sbjct: 1679 FVSFIFLC-SFLMLNLFVAVIMDN 1701
Score = 69.3 bits (168), Expect = 1e-09
Identities = 96/490 (19%), Positives = 186/490 (37%), Gaps = 41/490 (8%)
Frame = +1
Query: 1534 FVILFSMEMLLKMYSLGFTTYTTSQF----NRFDCFVVISSILEFVLVYF-DLMKPLGVS 1698
F +F+ EM++KM LG + + F N D VV +++ F F K ++
Sbjct: 1179 FTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSSFMGGSKGKDIN 1238
Query: 1699 VLRSARLLRIF---KVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFG 1869
++S R+LR+ K K +Q+F
Sbjct: 1239 TIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFK 1298
Query: 1870 GKFNFNPQQPK---------------------PRA------NFDTFVQALLTVFQILTGE 1968
GKF + + K PR ++D + ALLT+F + TGE
Sbjct: 1299 GKFFYCTDESKELERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGE 1358
Query: 1969 DWNTVMYHGI----ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSL 2136
W V+ H + E G + + I+Y+V F+ + +N+F+A+ + +
Sbjct: 1359 GWPMVLKHSVDATYEEQGPSPGFRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDK 1418
Query: 2137 TNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSARPRRMSEVPAASTVKPI 2316
+ S + + A + KP+
Sbjct: 1419 VMSE------------------------------------CSLEKNERACIDFAISAKPL 1442
Query: 2317 PKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMILN 2496
+ ++ + SF+ V F ++ I +++ +L + A ++L
Sbjct: 1443 TR----YMPQNKQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKF-YDAPYEYELMLK 1497
Query: 2497 YFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMS-- 2670
+ FTS+F++E LK+I FG++ ++ R+A+N+ D + V S+T ++ A +
Sbjct: 1498 CLNIVFTSMFSMECILKIIAFGVL----NYFRDAWNVFDFVTVLGSITDILVTEIANNFI 1553
Query: 2671 XXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFK 2850
+ + ++ ++ + + K + + L+ ML F++AIIG+Q+F
Sbjct: 1554 NLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF- 1612
Query: 2851 GTFFLCNDLS 2880
G L +D S
Sbjct: 1613 GNIALDDDTS 1622
Score = 57.0 bits (136), Expect = 5e-06
Identities = 56/264 (21%), Positives = 105/264 (39%), Gaps = 3/264 (1%)
Frame = +1
Query: 2293 AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN 2472
A +++K SS + FR F +V F VL C++ + + A
Sbjct: 449 ARASLKSGKTESSSYFRRKEKMFRFFIRRMVKAQSFYWVVL-CVVALNTLCVAMVHYNQP 507
Query: 2473 STRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL 2652
L + ++ F +F E++LK+ G S+ R++FN D V+ S+ V
Sbjct: 508 QRLTTALYFAEFVFLGLFLTEMSLKMYGLG----PRSYFRSSFNCFDFGVIVGSIFEVVW 563
Query: 2653 RTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
K L+++V ++ ++K+I +++ + F+ +F
Sbjct: 564 AAIKPGTSFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVF 623
Query: 2824 AIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGD 3003
A++G+QLF G F +++D PT NFD
Sbjct: 624 ALLGMQLFGGQF-------------------NFQDETPTT-------------NFDTFPA 651
Query: 3004 AMISLFVVSTFEGWPQLLYVAIDS 3075
A++++F + T E W ++Y I+S
Sbjct: 652 AILTVFQILTGEDWNAVMYHGIES 675
>gi|11279258|pir||T45115 N-type calcium channel alpha-1 chain,
omega-conotoxin-sensitive [imported] - human
gi|179760|gb|AAA51898.1| N-type calcium channel alpha-1 subunit
Length = 2237
Score = 665 bits (1717), Expect = 0.0
Identities = 354/783 (45%), Positives = 492/783 (62%), Gaps = 11/783 (1%)
Frame = +1
Query: 2308 KPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNM 2487
+PI SS+F LS TN R FC+ +V YF +L I +SS LAAEDP++ +S RN
Sbjct: 1122 RPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPRNN 1181
Query: 2488 ILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL---RT 2658
L Y DY FT VFT E+ +K+I GL+ H G++ R+ +N+LD +VV+ +L +F +
Sbjct: 1182 ALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKG 1241
Query: 2659 DAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGV 2838
++ I R LK V CV+ ++K + NI++V + F+FA+I V
Sbjct: 1242 KDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAV 1301
Query: 2839 QLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISL 3018
QLFKG FF C D SK E +CRG+Y+ YE + ++ R W DF++DNV A+++L
Sbjct: 1302 QLFKGKFFYCTDESKELERDCRGQYLDYEKEEVE---AQPRQWKKYDFHYDNVLWALLTL 1358
Query: 3019 FVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIVT 3198
F VST EGWP +L ++D+ E++GP R +++ +I+T
Sbjct: 1359 FTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIIT 1418
Query: 3199 FQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRAFEYVIF 3372
FQ +G++ C L+KN+R CI+FA+ AKP RY+P+NR QY+ W FV S FEY I
Sbjct: 1419 FQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIM 1478
Query: 3373 LIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVF 3552
+I +NTV L K Y + +E L N++FT +F+ E VLKI+A NY D WNVF
Sbjct: 1479 AMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVF 1538
Query: 3553 DLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQ 3732
D + V+GS DI ++ N I+++F RLFR RL+KLL +G IR LLWTF++SF+
Sbjct: 1539 DFVTVLGSITDILVTEIAETN-NFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFK 1597
Query: 3733 ALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAW 3912
ALPYV LLI +LFFIYA+IGMQ FG +ALDD TSI+R+NNF +F A+++LFRSATGEAW
Sbjct: 1598 ALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAW 1657
Query: 3913 QDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVI 4092
+IMLSC + CD + N + CG++FAY YF+SF LCSFL++NLFVAVI
Sbjct: 1658 HEIMLSCLSNQ--ACDEQA--------NATECGSDFAYFYFVSFIFLCSFLMLNLFVAVI 1707
Query: 4093 MDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCP 4272
MDNF+YLTRD SILGPHHL+EF+R+W+EYDP A GRI + D+ +L+ +SPPLG GK CP
Sbjct: 1708 MDNFEYLTRDSSILGPHHLDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCP 1767
Query: 4273 HRLACKRLVSMNMPL-NSDGTVCFNATLFALVRTNLKIY---TEGNIDEANEQLRSAIKR 4440
R+A KRLV MNMP+ N D TV F +TL AL+RT L+I + + +LR I
Sbjct: 1768 ARVAYKRLVRMNMPISNEDMTVHFTSTLMALIRTALEIKLAPAGTKQHQCDAELRKEISV 1827
Query: 4441 IWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKE--MEAKGVLPAQTP 4614
+W + LD +VPP K D++TVGK YA +I D++++ K ++ +A G L P
Sbjct: 1828 VWANLPQKTLDLLVPP-HKPDEMTVGKVYAALMIFDFYKQNKTTRDQMQQAPGGLSQMGP 1886
Query: 4615 QAM 4623
++
Sbjct: 1887 VSL 1889
Score = 511 bits (1317), Expect = e-143
Identities = 292/664 (43%), Positives = 374/664 (55%), Gaps = 24/664 (3%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N +RK I EW PFE++IL I ANCI LA+ Q P D + L+ E FI +
Sbjct: 81 DNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGI 140
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KI+A+GF+FH +YLRN WN++DF++V+ G+++T + FD++ LRA R
Sbjct: 141 FCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTD-----FDLRTLRAVR 195
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQVVL +I++AM+PLL I LL+ F IL++AIIGLE + GK H C
Sbjct: 196 VLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFP 255
Query: 760 PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFG 939
+T D PCG E A C+ EC WPGPN GITNFDN
Sbjct: 256 NSTDAEPVGD-FPCGK--EAPARLCEGDT---------ECREY--WPGPNFGITNFDNIL 301
Query: 940 LAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSK 1119
A+LTVFQC+++EGWTD++Y NDA G W W+YF+ L+I+GSFF+LNLVLGVLSGEF+K
Sbjct: 302 FAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAK 361
Query: 1120 EREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDE--QEDEPVAQTXXXXX 1293
ERE+ R F K R +QQ+E +L GYL+WI +AE++ ED +E P+
Sbjct: 362 ERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAAT 421
Query: 1294 XXXXXXXXXXXXXPSKWA----------------------ARMKRLEKLNXXXXXXXXXL 1407
++A + +R EK+ +
Sbjct: 422 KKSRNDLIHAEEGEDRFADLCAVGSPFARASLKSGKTESSSYFRRKEKM---FRFFIRRM 478
Query: 1408 VKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGF 1587
VK+Q+FYW HY Q L A F+ LF EM LKMY LG
Sbjct: 479 VKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLGP 538
Query: 1588 TTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXX 1767
+Y S FN FD V++ S+ E V G+SVLR+ RLLRIFKVTKYW+
Sbjct: 539 RSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSSLRNL 598
Query: 1768 XXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTV 1947
GMQ+FGG+FNF Q P NFDTF A+LTV
Sbjct: 599 VVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF--QDETPTTNFDTFPAAILTV 656
Query: 1948 FQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADA 2127
FQILTGEDWN VMYHGIES GGV + G+ Y+IVL + GNY LLNVFLAIAVDNLA+A
Sbjct: 657 FQILTGEDWNAVMYHGIESQGGV-SKGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANA 715
Query: 2128 DSLT 2139
LT
Sbjct: 716 QELT 719
Score = 132 bits (331), Expect = 1e-28
Identities = 92/322 (28%), Positives = 162/322 (49%), Gaps = 10/322 (3%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
N +R+ C IV + FE +IL +I + IALA P + +N L+ ++Y+F VF
Sbjct: 1137 NLLRRFCHYIVTMRYFEVVILVVIALSSIALAAEDP--VRTDSPRNNALKYLDYIFTGVF 1194
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD-VKALRAFR 579
T E V+K++ +G + HP AY R+ WNILDFI+V LV+ S + + +K+LR R
Sbjct: 1195 TFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLR 1254
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF GK C D
Sbjct: 1255 VLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF-YCTD 1313
Query: 760 PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFG 939
+ + ++D D E + QP +W+ ++DN
Sbjct: 1314 ES--KELERDCRGQYLDYEKEEVEAQPR--------QWKKYD-----------FHYDNVL 1352
Query: 940 LAMLTVFQCVSLEGWTDVMYWVNDAVGREWP---------WIYFVTLVILGSFFVLNLVL 1092
A+LT+F + EGW V+ DA E I++V ++ FF +N+ +
Sbjct: 1353 WALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFV 1412
Query: 1093 GVLSGEFSKEREKARARGLFQK 1158
++ F ++ +K + +K
Sbjct: 1413 ALIIITFQEQGDKVMSECSLEK 1434
Score = 124 bits (311), Expect = 3e-26
Identities = 82/293 (27%), Positives = 143/293 (47%), Gaps = 8/293 (2%)
Frame = +1
Query: 3268 FALKAKPHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFL 3447
F K K R +I R V +++F +V+ ++ +NT+ +A HY R L
Sbjct: 464 FRRKEKMFRFFIRR---------MVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTL 514
Query: 3448 DVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLI 3627
+F G+F E LK+ L P++Y +N FD V+VGS ++ + + PG +
Sbjct: 515 YFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSS--F 572
Query: 3628 SINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF- 3804
I+ R R++R+ K+ +R L+ + + S +++ + L+ L ++A++GMQ F
Sbjct: 573 GISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFG 632
Query: 3805 GKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYH- 3981
G+ D T NF +FPAAIL +F+ TGE W +M YH
Sbjct: 633 GQFNFQDETP---TTNFDTFPAAILTVFQILTGEDWNAVM-----------------YHG 672
Query: 3982 ---KGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF---DYLTRD 4122
+GG+++ F+ YFI + ++ ++N+F+A+ +DN LT+D
Sbjct: 673 IESQGGVSKGM----FSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 721
Score = 94.7 bits (234), Expect = 2e-17
Identities = 75/297 (25%), Positives = 135/297 (45%), Gaps = 14/297 (4%)
Frame = +1
Query: 265 PFEFLILFMICANCIALAIYQPYPAQDSDYKNTL-LETIEYVFIVVFTIECVLKIVAMGF 441
PFE+ I+ MI N + L + D+ Y+ L L+ + VF +F++ECVLKI+A G
Sbjct: 1472 PFEYFIMAMIALNTVVLMM----KFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGV 1527
Query: 442 MFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKALRAFRVLRPLRLVSGVP 615
+ Y R+AWN+ DF+ V+ + ++++++ ++ LR FR R ++L+
Sbjct: 1528 L----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGY 1583
Query: 616 SLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPT 795
+++++L +++ L ++ LL+ + IYAIIG+++F G +A D T
Sbjct: 1584 TIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------GNIALDDDT 1630
Query: 796 PCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSL 975
N NF F A++ +F+ +
Sbjct: 1631 SI------------------------------------NRHNNFRTFLQALMLLFRSATG 1654
Query: 976 EGWTDVMY--WVNDA---------VGREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
E W ++M N A G ++ + YFV+ + L SF +LNL + V+ F
Sbjct: 1655 EAWHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1711
Score = 90.5 bits (223), Expect = 4e-16
Identities = 73/263 (27%), Positives = 120/263 (44%), Gaps = 14/263 (5%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLF+ S N R + + F +L I+ + +LA E L M L+
Sbjct: 74 SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 133
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV-----AVSLTSFVLRTDAM 2667
+ +F +F E +K+I G VFHKGS+ RN +N++D +VV A + T F LRT
Sbjct: 134 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDFDLRT--- 190
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
++ L+ V++ ++ A+ + I L+ F MFAIIG++ +
Sbjct: 191 -----LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY 245
Query: 2848 KGTFFLCNDLSKMTEAECRGEYIHYEDGDPTK----PVSKKRVWSNNDF---NFDNVGDA 3006
G F T+AE G++ ++ P + + W +F NFDN+ A
Sbjct: 246 MGKFHKA-CFPNSTDAEPVGDFPCGKEA-PARLCEGDTECREYWPGPNFGITNFDNILFA 303
Query: 3007 MISLFVVSTFEGWPQLLYVAIDS 3075
++++F T EGW +LY D+
Sbjct: 304 ILTVFQCITMEGWTDILYNTNDA 326
Score = 87.0 bits (214), Expect = 5e-15
Identities = 77/292 (26%), Positives = 123/292 (41%), Gaps = 42/292 (14%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY+I I+ N + LA + H P + LD F G+F FEA +KI+AL
Sbjct: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WNV D +VV+ G L GT+ + R RV+R +KL+S
Sbjct: 157 HKGSYLRNGWNVMDFVVVL-------TGILATAGTD-FDLRTLRAVRVLRPLKLVSGIPS 208
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQF----FGKVALDDSTSIH------- 3840
++ +L + MK+ L + LL+ ++A+IG++F F K +ST
Sbjct: 209 LQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPC 268
Query: 3841 ------------------------RNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDRED 3948
NF + AIL +F+ T E W DI+ + +D
Sbjct: 269 GKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTND--- 325
Query: 3949 VRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
GN + + YFI ++ SF ++NL + V+ F
Sbjct: 326 ------------------AAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 359
Score = 71.2 bits (173), Expect = 3e-10
Identities = 96/491 (19%), Positives = 185/491 (37%), Gaps = 42/491 (8%)
Frame = +1
Query: 1534 FVILFSMEMLLKMYSLGFTTYTTSQF----NRFDCFVVISSILEFVLVYFDLMKPLGVSV 1701
F +F+ EM++KM LG + + F N D VV +++ F F K ++
Sbjct: 1190 FTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFA---FSGSKGKDINT 1246
Query: 1702 LRSARLLRIF---KVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGG 1872
++S R+LR+ K K +Q+F G
Sbjct: 1247 IKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKG 1306
Query: 1873 KFNFNPQQPK---------------------PRA------NFDTFVQALLTVFQILTGED 1971
KF + + K PR ++D + ALLT+F + TGE
Sbjct: 1307 KFFYCTDESKELERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEG 1366
Query: 1972 WNTVMYHGI----ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLT 2139
W V+ H + E G + + I+Y+V F+ + +N+F+A+ + +
Sbjct: 1367 WPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKV 1426
Query: 2140 NAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSARPRRMSEVPAASTVKPIP 2319
+ S + + A + KP+
Sbjct: 1427 MSE------------------------------------CSLEKNERACIDFAISAKPLT 1450
Query: 2320 KASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMILNY 2499
+ ++ + SF+ V F ++ I +++ +L + A ++L
Sbjct: 1451 R----YMPQNRQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKF-YDAPYEYELMLKC 1505
Query: 2500 FDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSF----VLRTDAM 2667
+ FTS+F++E LK+I FG++ ++ R+A+N+ D + V S+T + T+
Sbjct: 1506 LNIVFTSMFSMECVLKIIAFGVL----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNF 1561
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
+ + ++ ++ + + K + + L+ ML F++AIIG+Q+F
Sbjct: 1562 INLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1621
Query: 2848 KGTFFLCNDLS 2880
G L +D S
Sbjct: 1622 -GNIALDDDTS 1631
Score = 70.1 bits (170), Expect = 6e-10
Identities = 52/205 (25%), Positives = 87/205 (42%), Gaps = 8/205 (3%)
Frame = +1
Query: 1525 NLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYF-DLMKPLGVSV 1701
N+ F +FSME +LK+ + G Y +N FD V+ SI + ++ + + +S
Sbjct: 1507 NIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSF 1566
Query: 1702 LRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFN 1881
LR R R+ K+ + GMQVFG
Sbjct: 1567 LRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIAL 1626
Query: 1882 FNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMY-----HGIESFGGVGTLGVIVCIY 2046
+ NF TF+QAL+ +F+ TGE W+ +M + G +
Sbjct: 1627 DDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACDEQANATECGSDFAYF 1686
Query: 2047 YIV--LFICGNYILLNVFLAIAVDN 2115
Y V +F+C ++++LN+F+A+ +DN
Sbjct: 1687 YFVSFIFLC-SFLMLNLFVAVIMDN 1710
Score = 57.0 bits (136), Expect = 5e-06
Identities = 58/267 (21%), Positives = 110/267 (40%), Gaps = 6/267 (2%)
Frame = +1
Query: 2293 AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSS---AMLAAEDPL 2463
A +++K SS + FR F +V F VL + +++ AM+ P
Sbjct: 449 ARASLKSGKTESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPR 508
Query: 2464 QANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTS 2643
+ +T L + ++ F +F E++LK+ G S+ R++FN D V+ S+
Sbjct: 509 RLTTT----LYFAEFVFLGLFLTEMSLKMYGLG----PRSYFRSSFNCFDFGVIVGSVFE 560
Query: 2644 FVLRTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQ 2814
V K L+++V ++ ++K+I +++ + F+
Sbjct: 561 VVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFI 620
Query: 2815 FMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDN 2994
+FA++G+QLF G F +++D PT NFD
Sbjct: 621 VVFALLGMQLFGGQF-------------------NFQDETPTT-------------NFDT 648
Query: 2995 VGDAMISLFVVSTFEGWPQLLYVAIDS 3075
A++++F + T E W ++Y I+S
Sbjct: 649 FPAAILTVFQILTGEDWNAVMYHGIES 675
>gi|284339|pir||A42566 omega-conotoxin-sensitive N-type calcium
channel alpha 1B-1 subunit (alternatively spliced) -
human
Length = 2339
Score = 665 bits (1717), Expect = 0.0
Identities = 354/783 (45%), Positives = 492/783 (62%), Gaps = 11/783 (1%)
Frame = +1
Query: 2308 KPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNM 2487
+PI SS+F LS TN R FC+ +V YF +L I +SS LAAEDP++ +S RN
Sbjct: 1122 RPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPRNN 1181
Query: 2488 ILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL---RT 2658
L Y DY FT VFT E+ +K+I GL+ H G++ R+ +N+LD +VV+ +L +F +
Sbjct: 1182 ALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKG 1241
Query: 2659 DAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGV 2838
++ I R LK V CV+ ++K + NI++V + F+FA+I V
Sbjct: 1242 KDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAV 1301
Query: 2839 QLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISL 3018
QLFKG FF C D SK E +CRG Y+ YE + ++ R W DF++DNV A+++L
Sbjct: 1302 QLFKGKFFYCTDESKELERDCRGGYLDYEKEEVE---AQPRQWKKYDFHYDNVLWALLTL 1358
Query: 3019 FVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIVT 3198
F VST EGWP +L ++D+ E++GP R +++ +I+T
Sbjct: 1359 FTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIIT 1418
Query: 3199 FQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRAFEYVIF 3372
FQ +G++ C L+KN+R CI+FA+ AKP RY+P+NR QY+ W FV S FEY I
Sbjct: 1419 FQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIM 1478
Query: 3373 LIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVF 3552
+I +NTV L K Y + +E L N++FT +F+ E VLKI+A NY D WNVF
Sbjct: 1479 AMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVF 1538
Query: 3553 DLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQ 3732
D + V+GS DI ++ N I+++F RLFR RL+KLL +G IR LLWTF++SF+
Sbjct: 1539 DFVTVLGSITDILVTEIAETN-NFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFK 1597
Query: 3733 ALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAW 3912
ALPYV LLI +LFFIYA+IGMQ FG +ALDD TSI+R+NNF +F A+++LFRSATGEAW
Sbjct: 1598 ALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAW 1657
Query: 3913 QDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVI 4092
+IMLSC + CD + N + CG++FAY YF+SF LCSFL++NLFVAVI
Sbjct: 1658 HEIMLSCLSNQ--ACDEQA--------NATECGSDFAYFYFVSFIFLCSFLMLNLFVAVI 1707
Query: 4093 MDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCP 4272
MDNF+YLTRD SILGPHHL+EF+R+W+EYDP A GRI + D+ +L+ +SPPLG GK CP
Sbjct: 1708 MDNFEYLTRDSSILGPHHLDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCP 1767
Query: 4273 HRLACKRLVSMNMPL-NSDGTVCFNATLFALVRTNLKIY---TEGNIDEANEQLRSAIKR 4440
R+A KRLV MNMP+ N D TV F +TL AL+RT L+I + + + +LR I
Sbjct: 1768 ARVAYKRLVRMNMPISNEDMTVHFTSTLMALIRTALEIKLAPAQTKQHQCDAELRKEISV 1827
Query: 4441 IWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKE--MEAKGVLPAQTP 4614
+W + LD +VPP K D++TVGK YA +I D++++ K ++ +A G L P
Sbjct: 1828 VWANLPQKTLDLLVPP-HKPDEMTVGKVYAALMIFDFYKQNKTTRDQMQQAPGGLSQMGP 1886
Query: 4615 QAM 4623
++
Sbjct: 1887 VSL 1889
Score = 511 bits (1315), Expect = e-142
Identities = 291/664 (43%), Positives = 372/664 (55%), Gaps = 24/664 (3%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N +RK I EW PFE++IL I ANCI LA+ Q P D + L+ E FI +
Sbjct: 81 DNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGI 140
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KI+A+GF+FH +YLRN WN++DF++V+ G+++T + FD++ LRA R
Sbjct: 141 FCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTD-----FDLRTLRAVR 195
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQVVL +I++AM+PLL I LL+ F IL++AIIGLE + GK H C
Sbjct: 196 VLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFP 255
Query: 760 PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFG 939
+T D P G F CQ EC WPGPN GITNFDN
Sbjct: 256 NST------DAEPVGD------FPCQKEAPARLCEGDTECREY--WPGPNFGITNFDNIL 301
Query: 940 LAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSK 1119
A+LTVFQC+++EGWTD++Y NDA G W W+YF+ L+I+GSFF+LNLVLGVLSGEF+K
Sbjct: 302 FAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAK 361
Query: 1120 EREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDE--QEDEPVAQTXXXXX 1293
ERE+ R F K R +QQ+E +L GYL+WI +AE++ ED +E P+
Sbjct: 362 ERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAAT 421
Query: 1294 XXXXXXXXXXXXXPSKWA----------------------ARMKRLEKLNXXXXXXXXXL 1407
++A + +R EK+ +
Sbjct: 422 KKSRNDLIHAEEGEDRFADLCAVGSPFARASLKSGKTESSSYFRRKEKM---FRFFIRRM 478
Query: 1408 VKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGF 1587
VK+Q+FYW HY Q L A F+ LF EM LKMY LG
Sbjct: 479 VKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLGP 538
Query: 1588 TTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXX 1767
+Y S FN FD V++ S+ E V G+SVLR+ RLLRIFKVTKYW+
Sbjct: 539 RSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGGSFGISVLRALRLLRIFKVTKYWSSLRNL 598
Query: 1768 XXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTV 1947
GMQ+FGG+FNF Q P NFDTF A+LTV
Sbjct: 599 VVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF--QDETPTTNFDTFPAAILTV 656
Query: 1948 FQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADA 2127
FQILTGEDWN VMYHGIES GGV + G+ Y+IVL + GNY LLNVFLAIAVDNLA+A
Sbjct: 657 FQILTGEDWNAVMYHGIESQGGV-SKGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANA 715
Query: 2128 DSLT 2139
LT
Sbjct: 716 QELT 719
Score = 132 bits (331), Expect = 1e-28
Identities = 92/322 (28%), Positives = 162/322 (49%), Gaps = 10/322 (3%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
N +R+ C IV + FE +IL +I + IALA P + +N L+ ++Y+F VF
Sbjct: 1137 NLLRRFCHYIVTMRYFEVVILVVIALSSIALAAEDP--VRTDSPRNNALKYLDYIFTGVF 1194
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD-VKALRAFR 579
T E V+K++ +G + HP AY R+ WNILDFI+V LV+ S + + +K+LR R
Sbjct: 1195 TFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLR 1254
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF GK C D
Sbjct: 1255 VLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF-YCTD 1313
Query: 760 PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFG 939
+ + ++D D E + QP +W+ ++DN
Sbjct: 1314 ES--KELERDCRGGYLDYEKEEVEAQPR--------QWKKYD-----------FHYDNVL 1352
Query: 940 LAMLTVFQCVSLEGWTDVMYWVNDAVGREWP---------WIYFVTLVILGSFFVLNLVL 1092
A+LT+F + EGW V+ DA E I++V ++ FF +N+ +
Sbjct: 1353 WALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFV 1412
Query: 1093 GVLSGEFSKEREKARARGLFQK 1158
++ F ++ +K + +K
Sbjct: 1413 ALIIITFQEQGDKVMSECSLEK 1434
Score = 126 bits (317), Expect = 5e-27
Identities = 83/293 (28%), Positives = 144/293 (48%), Gaps = 8/293 (2%)
Frame = +1
Query: 3268 FALKAKPHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFL 3447
F K K R +I R V +++F +V+ ++ +NT+ +A HY R L
Sbjct: 464 FRRKEKMFRFFIRR---------MVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTL 514
Query: 3448 DVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLI 3627
+F G+F E LK+ L P++Y +N FD V+VGS ++ + + PGG+
Sbjct: 515 YFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGGS--F 572
Query: 3628 SINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF- 3804
I+ R R++R+ K+ +R L+ + + S +++ + L+ L ++A++GMQ F
Sbjct: 573 GISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFG 632
Query: 3805 GKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYH- 3981
G+ D T NF +FPAAIL +F+ TGE W +M YH
Sbjct: 633 GQFNFQDETP---TTNFDTFPAAILTVFQILTGEDWNAVM-----------------YHG 672
Query: 3982 ---KGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF---DYLTRD 4122
+GG+++ F+ YFI + ++ ++N+F+A+ +DN LT+D
Sbjct: 673 IESQGGVSKGM----FSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 721
Score = 94.7 bits (234), Expect = 2e-17
Identities = 75/297 (25%), Positives = 135/297 (45%), Gaps = 14/297 (4%)
Frame = +1
Query: 265 PFEFLILFMICANCIALAIYQPYPAQDSDYKNTL-LETIEYVFIVVFTIECVLKIVAMGF 441
PFE+ I+ MI N + L + D+ Y+ L L+ + VF +F++ECVLKI+A G
Sbjct: 1472 PFEYFIMAMIALNTVVLMM----KFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGV 1527
Query: 442 MFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKALRAFRVLRPLRLVSGVP 615
+ Y R+AWN+ DF+ V+ + ++++++ ++ LR FR R ++L+
Sbjct: 1528 L----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGY 1583
Query: 616 SLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPT 795
+++++L +++ L ++ LL+ + IYAIIG+++F G +A D T
Sbjct: 1584 TIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------GNIALDDDT 1630
Query: 796 PCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSL 975
N NF F A++ +F+ +
Sbjct: 1631 SI------------------------------------NRHNNFRTFLQALMLLFRSATG 1654
Query: 976 EGWTDVMY--WVNDA---------VGREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
E W ++M N A G ++ + YFV+ + L SF +LNL + V+ F
Sbjct: 1655 EAWHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1711
Score = 91.3 bits (225), Expect = 2e-16
Identities = 73/263 (27%), Positives = 120/263 (44%), Gaps = 14/263 (5%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLF+ S N R + + F +L I+ + +LA E L M L+
Sbjct: 74 SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 133
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV-----AVSLTSFVLRTDAM 2667
+ +F +F E +K+I G VFHKGS+ RN +N++D +VV A + T F LRT
Sbjct: 134 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDFDLRT--- 190
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
++ L+ V++ ++ A+ + I L+ F MFAIIG++ +
Sbjct: 191 -----LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY 245
Query: 2848 KGTFFLCNDLSKMTEAECRGEYIHYEDGDPTK----PVSKKRVWSNNDF---NFDNVGDA 3006
G F T+AE G++ ++ P + + W +F NFDN+ A
Sbjct: 246 MGKFHKA-CFPNSTDAEPVGDFPCQKEA-PARLCEGDTECREYWPGPNFGITNFDNILFA 303
Query: 3007 MISLFVVSTFEGWPQLLYVAIDS 3075
++++F T EGW +LY D+
Sbjct: 304 ILTVFQCITMEGWTDILYNTNDA 326
Score = 87.0 bits (214), Expect = 5e-15
Identities = 77/292 (26%), Positives = 123/292 (41%), Gaps = 42/292 (14%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY+I I+ N + LA + H P + LD F G+F FEA +KI+AL
Sbjct: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WNV D +VV+ G L GT+ + R RV+R +KL+S
Sbjct: 157 HKGSYLRNGWNVMDFVVVL-------TGILATAGTD-FDLRTLRAVRVLRPLKLVSGIPS 208
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQF----FGKVALDDSTSIH------- 3840
++ +L + MK+ L + LL+ ++A+IG++F F K +ST
Sbjct: 209 LQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPC 268
Query: 3841 ------------------------RNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDRED 3948
NF + AIL +F+ T E W DI+ + +D
Sbjct: 269 QKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTND--- 325
Query: 3949 VRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
GN + + YFI ++ SF ++NL + V+ F
Sbjct: 326 ------------------AAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 359
Score = 71.2 bits (173), Expect = 3e-10
Identities = 96/491 (19%), Positives = 185/491 (37%), Gaps = 42/491 (8%)
Frame = +1
Query: 1534 FVILFSMEMLLKMYSLGFTTYTTSQF----NRFDCFVVISSILEFVLVYFDLMKPLGVSV 1701
F +F+ EM++KM LG + + F N D VV +++ F F K ++
Sbjct: 1190 FTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFA---FSGSKGKDINT 1246
Query: 1702 LRSARLLRIF---KVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGG 1872
++S R+LR+ K K +Q+F G
Sbjct: 1247 IKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKG 1306
Query: 1873 KFNFNPQQPK---------------------PRA------NFDTFVQALLTVFQILTGED 1971
KF + + K PR ++D + ALLT+F + TGE
Sbjct: 1307 KFFYCTDESKELERDCRGGYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEG 1366
Query: 1972 WNTVMYHGI----ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLT 2139
W V+ H + E G + + I+Y+V F+ + +N+F+A+ + +
Sbjct: 1367 WPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKV 1426
Query: 2140 NAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSARPRRMSEVPAASTVKPIP 2319
+ S + + A + KP+
Sbjct: 1427 MSE------------------------------------CSLEKNERACIDFAISAKPLT 1450
Query: 2320 KASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMILNY 2499
+ ++ + SF+ V F ++ I +++ +L + A ++L
Sbjct: 1451 R----YMPQNRQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKF-YDAPYEYELMLKC 1505
Query: 2500 FDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSF----VLRTDAM 2667
+ FTS+F++E LK+I FG++ ++ R+A+N+ D + V S+T + T+
Sbjct: 1506 LNIVFTSMFSMECVLKIIAFGVL----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNF 1561
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
+ + ++ ++ + + K + + L+ ML F++AIIG+Q+F
Sbjct: 1562 INLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1621
Query: 2848 KGTFFLCNDLS 2880
G L +D S
Sbjct: 1622 -GNIALDDDTS 1631
Score = 70.1 bits (170), Expect = 6e-10
Identities = 52/205 (25%), Positives = 87/205 (42%), Gaps = 8/205 (3%)
Frame = +1
Query: 1525 NLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYF-DLMKPLGVSV 1701
N+ F +FSME +LK+ + G Y +N FD V+ SI + ++ + + +S
Sbjct: 1507 NIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSF 1566
Query: 1702 LRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFN 1881
LR R R+ K+ + GMQVFG
Sbjct: 1567 LRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIAL 1626
Query: 1882 FNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMY-----HGIESFGGVGTLGVIVCIY 2046
+ NF TF+QAL+ +F+ TGE W+ +M + G +
Sbjct: 1627 DDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACDEQANATECGSDFAYF 1686
Query: 2047 YIV--LFICGNYILLNVFLAIAVDN 2115
Y V +F+C ++++LN+F+A+ +DN
Sbjct: 1687 YFVSFIFLC-SFLMLNLFVAVIMDN 1710
Score = 56.6 bits (135), Expect = 7e-06
Identities = 58/267 (21%), Positives = 110/267 (40%), Gaps = 6/267 (2%)
Frame = +1
Query: 2293 AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSS---AMLAAEDPL 2463
A +++K SS + FR F +V F VL + +++ AM+ P
Sbjct: 449 ARASLKSGKTESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPR 508
Query: 2464 QANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTS 2643
+ +T L + ++ F +F E++LK+ G S+ R++FN D V+ S+
Sbjct: 509 RLTTT----LYFAEFVFLGLFLTEMSLKMYGLG----PRSYFRSSFNCFDFGVIVGSVFE 560
Query: 2644 FVLRTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQ 2814
V K L+++V ++ ++K+I +++ + F+
Sbjct: 561 VVWAAIKPGGSFGISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFI 620
Query: 2815 FMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDN 2994
+FA++G+QLF G F +++D PT NFD
Sbjct: 621 VVFALLGMQLFGGQF-------------------NFQDETPTT-------------NFDT 648
Query: 2995 VGDAMISLFVVSTFEGWPQLLYVAIDS 3075
A++++F + T E W ++Y I+S
Sbjct: 649 FPAAILTVFQILTGEDWNAVMYHGIES 675
>gi|4502523|ref|NP_000709.1| calcium channel, voltage-dependent, L
type, alpha 1B subunit; calcium channel, N type; calcium
channel, voltage-dependent, alpha 1B subunit, N type
[Homo sapiens]
gi|1705854|sp|Q00975|CCAB_HUMAN Voltage-dependent N-type calcium
channel alpha-1B subunit (Voltage-gated calcium channel
alpha subunit Cav2.2) (Calcium channel, L type, alpha-1
polypeptide isoform 5) (Brain calcium channel III) (BIII)
gi|179758|gb|AAA51897.1| N-type calcium channel alpha-1 subunit
Length = 2339
Score = 665 bits (1717), Expect = 0.0
Identities = 354/783 (45%), Positives = 492/783 (62%), Gaps = 11/783 (1%)
Frame = +1
Query: 2308 KPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNM 2487
+PI SS+F LS TN R FC+ +V YF +L I +SS LAAEDP++ +S RN
Sbjct: 1122 RPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPRNN 1181
Query: 2488 ILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL---RT 2658
L Y DY FT VFT E+ +K+I GL+ H G++ R+ +N+LD +VV+ +L +F +
Sbjct: 1182 ALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKG 1241
Query: 2659 DAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGV 2838
++ I R LK V CV+ ++K + NI++V + F+FA+I V
Sbjct: 1242 KDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAV 1301
Query: 2839 QLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISL 3018
QLFKG FF C D SK E +CRG+Y+ YE + ++ R W DF++DNV A+++L
Sbjct: 1302 QLFKGKFFYCTDESKELERDCRGQYLDYEKEEVE---AQPRQWKKYDFHYDNVLWALLTL 1358
Query: 3019 FVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIVT 3198
F VST EGWP +L ++D+ E++GP R +++ +I+T
Sbjct: 1359 FTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIIT 1418
Query: 3199 FQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRAFEYVIF 3372
FQ +G++ C L+KN+R CI+FA+ AKP RY+P+NR QY+ W FV S FEY I
Sbjct: 1419 FQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIM 1478
Query: 3373 LIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVF 3552
+I +NTV L K Y + +E L N++FT +F+ E VLKI+A NY D WNVF
Sbjct: 1479 AMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVF 1538
Query: 3553 DLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQ 3732
D + V+GS DI ++ N I+++F RLFR RL+KLL +G IR LLWTF++SF+
Sbjct: 1539 DFVTVLGSITDILVTEIAETN-NFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFK 1597
Query: 3733 ALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAW 3912
ALPYV LLI +LFFIYA+IGMQ FG +ALDD TSI+R+NNF +F A+++LFRSATGEAW
Sbjct: 1598 ALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAW 1657
Query: 3913 QDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVI 4092
+IMLSC + CD + N + CG++FAY YF+SF LCSFL++NLFVAVI
Sbjct: 1658 HEIMLSCLSNQ--ACDEQA--------NATECGSDFAYFYFVSFIFLCSFLMLNLFVAVI 1707
Query: 4093 MDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCP 4272
MDNF+YLTRD SILGPHHL+EF+R+W+EYDP A GRI + D+ +L+ +SPPLG GK CP
Sbjct: 1708 MDNFEYLTRDSSILGPHHLDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCP 1767
Query: 4273 HRLACKRLVSMNMPL-NSDGTVCFNATLFALVRTNLKIY---TEGNIDEANEQLRSAIKR 4440
R+A KRLV MNMP+ N D TV F +TL AL+RT L+I + + +LR I
Sbjct: 1768 ARVAYKRLVRMNMPISNEDMTVHFTSTLMALIRTALEIKLAPAGTKQHQCDAELRKEISV 1827
Query: 4441 IWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKE--MEAKGVLPAQTP 4614
+W + LD +VPP K D++TVGK YA +I D++++ K ++ +A G L P
Sbjct: 1828 VWANLPQKTLDLLVPP-HKPDEMTVGKVYAALMIFDFYKQNKTTRDQMQQAPGGLSQMGP 1886
Query: 4615 QAM 4623
++
Sbjct: 1887 VSL 1889
Score = 511 bits (1317), Expect = e-143
Identities = 292/664 (43%), Positives = 374/664 (55%), Gaps = 24/664 (3%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N +RK I EW PFE++IL I ANCI LA+ Q P D + L+ E FI +
Sbjct: 81 DNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGI 140
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KI+A+GF+FH +YLRN WN++DF++V+ G+++T + FD++ LRA R
Sbjct: 141 FCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTD-----FDLRTLRAVR 195
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQVVL +I++AM+PLL I LL+ F IL++AIIGLE + GK H C
Sbjct: 196 VLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFP 255
Query: 760 PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFG 939
+T D PCG E A C+ EC WPGPN GITNFDN
Sbjct: 256 NSTDAEPVGD-FPCGK--EAPARLCEGDT---------ECREY--WPGPNFGITNFDNIL 301
Query: 940 LAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSK 1119
A+LTVFQC+++EGWTD++Y NDA G W W+YF+ L+I+GSFF+LNLVLGVLSGEF+K
Sbjct: 302 FAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAK 361
Query: 1120 EREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDE--QEDEPVAQTXXXXX 1293
ERE+ R F K R +QQ+E +L GYL+WI +AE++ ED +E P+
Sbjct: 362 ERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAAT 421
Query: 1294 XXXXXXXXXXXXXPSKWA----------------------ARMKRLEKLNXXXXXXXXXL 1407
++A + +R EK+ +
Sbjct: 422 KKSRNDLIHAEEGEDRFADLCAVGSPFARASLKSGKTESSSYFRRKEKM---FRFFIRRM 478
Query: 1408 VKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGF 1587
VK+Q+FYW HY Q L A F+ LF EM LKMY LG
Sbjct: 479 VKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLGP 538
Query: 1588 TTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXX 1767
+Y S FN FD V++ S+ E V G+SVLR+ RLLRIFKVTKYW+
Sbjct: 539 RSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSSLRNL 598
Query: 1768 XXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTV 1947
GMQ+FGG+FNF Q P NFDTF A+LTV
Sbjct: 599 VVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF--QDETPTTNFDTFPAAILTV 656
Query: 1948 FQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADA 2127
FQILTGEDWN VMYHGIES GGV + G+ Y+IVL + GNY LLNVFLAIAVDNLA+A
Sbjct: 657 FQILTGEDWNAVMYHGIESQGGV-SKGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANA 715
Query: 2128 DSLT 2139
LT
Sbjct: 716 QELT 719
Score = 132 bits (331), Expect = 1e-28
Identities = 92/322 (28%), Positives = 162/322 (49%), Gaps = 10/322 (3%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
N +R+ C IV + FE +IL +I + IALA P + +N L+ ++Y+F VF
Sbjct: 1137 NLLRRFCHYIVTMRYFEVVILVVIALSSIALAAEDP--VRTDSPRNNALKYLDYIFTGVF 1194
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD-VKALRAFR 579
T E V+K++ +G + HP AY R+ WNILDFI+V LV+ S + + +K+LR R
Sbjct: 1195 TFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLR 1254
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF GK C D
Sbjct: 1255 VLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF-YCTD 1313
Query: 760 PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFG 939
+ + ++D D E + QP +W+ ++DN
Sbjct: 1314 ES--KELERDCRGQYLDYEKEEVEAQPR--------QWKKYD-----------FHYDNVL 1352
Query: 940 LAMLTVFQCVSLEGWTDVMYWVNDAVGREWP---------WIYFVTLVILGSFFVLNLVL 1092
A+LT+F + EGW V+ DA E I++V ++ FF +N+ +
Sbjct: 1353 WALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFV 1412
Query: 1093 GVLSGEFSKEREKARARGLFQK 1158
++ F ++ +K + +K
Sbjct: 1413 ALIIITFQEQGDKVMSECSLEK 1434
Score = 124 bits (311), Expect = 3e-26
Identities = 82/293 (27%), Positives = 143/293 (47%), Gaps = 8/293 (2%)
Frame = +1
Query: 3268 FALKAKPHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFL 3447
F K K R +I R V +++F +V+ ++ +NT+ +A HY R L
Sbjct: 464 FRRKEKMFRFFIRR---------MVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTL 514
Query: 3448 DVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLI 3627
+F G+F E LK+ L P++Y +N FD V+VGS ++ + + PG +
Sbjct: 515 YFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSS--F 572
Query: 3628 SINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF- 3804
I+ R R++R+ K+ +R L+ + + S +++ + L+ L ++A++GMQ F
Sbjct: 573 GISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFG 632
Query: 3805 GKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYH- 3981
G+ D T NF +FPAAIL +F+ TGE W +M YH
Sbjct: 633 GQFNFQDETP---TTNFDTFPAAILTVFQILTGEDWNAVM-----------------YHG 672
Query: 3982 ---KGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF---DYLTRD 4122
+GG+++ F+ YFI + ++ ++N+F+A+ +DN LT+D
Sbjct: 673 IESQGGVSKGM----FSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 721
Score = 94.7 bits (234), Expect = 2e-17
Identities = 75/297 (25%), Positives = 135/297 (45%), Gaps = 14/297 (4%)
Frame = +1
Query: 265 PFEFLILFMICANCIALAIYQPYPAQDSDYKNTL-LETIEYVFIVVFTIECVLKIVAMGF 441
PFE+ I+ MI N + L + D+ Y+ L L+ + VF +F++ECVLKI+A G
Sbjct: 1472 PFEYFIMAMIALNTVVLMM----KFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGV 1527
Query: 442 MFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKALRAFRVLRPLRLVSGVP 615
+ Y R+AWN+ DF+ V+ + ++++++ ++ LR FR R ++L+
Sbjct: 1528 L----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGY 1583
Query: 616 SLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPT 795
+++++L +++ L ++ LL+ + IYAIIG+++F G +A D T
Sbjct: 1584 TIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------GNIALDDDT 1630
Query: 796 PCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSL 975
N NF F A++ +F+ +
Sbjct: 1631 SI------------------------------------NRHNNFRTFLQALMLLFRSATG 1654
Query: 976 EGWTDVMY--WVNDA---------VGREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
E W ++M N A G ++ + YFV+ + L SF +LNL + V+ F
Sbjct: 1655 EAWHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1711
Score = 90.5 bits (223), Expect = 4e-16
Identities = 73/263 (27%), Positives = 120/263 (44%), Gaps = 14/263 (5%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLF+ S N R + + F +L I+ + +LA E L M L+
Sbjct: 74 SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 133
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV-----AVSLTSFVLRTDAM 2667
+ +F +F E +K+I G VFHKGS+ RN +N++D +VV A + T F LRT
Sbjct: 134 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDFDLRT--- 190
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
++ L+ V++ ++ A+ + I L+ F MFAIIG++ +
Sbjct: 191 -----LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY 245
Query: 2848 KGTFFLCNDLSKMTEAECRGEYIHYEDGDPTK----PVSKKRVWSNNDF---NFDNVGDA 3006
G F T+AE G++ ++ P + + W +F NFDN+ A
Sbjct: 246 MGKFHKA-CFPNSTDAEPVGDFPCGKEA-PARLCEGDTECREYWPGPNFGITNFDNILFA 303
Query: 3007 MISLFVVSTFEGWPQLLYVAIDS 3075
++++F T EGW +LY D+
Sbjct: 304 ILTVFQCITMEGWTDILYNTNDA 326
Score = 87.0 bits (214), Expect = 5e-15
Identities = 77/292 (26%), Positives = 123/292 (41%), Gaps = 42/292 (14%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY+I I+ N + LA + H P + LD F G+F FEA +KI+AL
Sbjct: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WNV D +VV+ G L GT+ + R RV+R +KL+S
Sbjct: 157 HKGSYLRNGWNVMDFVVVL-------TGILATAGTD-FDLRTLRAVRVLRPLKLVSGIPS 208
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQF----FGKVALDDSTSIH------- 3840
++ +L + MK+ L + LL+ ++A+IG++F F K +ST
Sbjct: 209 LQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPC 268
Query: 3841 ------------------------RNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDRED 3948
NF + AIL +F+ T E W DI+ + +D
Sbjct: 269 GKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTND--- 325
Query: 3949 VRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
GN + + YFI ++ SF ++NL + V+ F
Sbjct: 326 ------------------AAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 359
Score = 71.2 bits (173), Expect = 3e-10
Identities = 96/491 (19%), Positives = 185/491 (37%), Gaps = 42/491 (8%)
Frame = +1
Query: 1534 FVILFSMEMLLKMYSLGFTTYTTSQF----NRFDCFVVISSILEFVLVYFDLMKPLGVSV 1701
F +F+ EM++KM LG + + F N D VV +++ F F K ++
Sbjct: 1190 FTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFA---FSGSKGKDINT 1246
Query: 1702 LRSARLLRIF---KVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGG 1872
++S R+LR+ K K +Q+F G
Sbjct: 1247 IKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKG 1306
Query: 1873 KFNFNPQQPK---------------------PRA------NFDTFVQALLTVFQILTGED 1971
KF + + K PR ++D + ALLT+F + TGE
Sbjct: 1307 KFFYCTDESKELERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEG 1366
Query: 1972 WNTVMYHGI----ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLT 2139
W V+ H + E G + + I+Y+V F+ + +N+F+A+ + +
Sbjct: 1367 WPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKV 1426
Query: 2140 NAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSARPRRMSEVPAASTVKPIP 2319
+ S + + A + KP+
Sbjct: 1427 MSE------------------------------------CSLEKNERACIDFAISAKPLT 1450
Query: 2320 KASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMILNY 2499
+ ++ + SF+ V F ++ I +++ +L + A ++L
Sbjct: 1451 R----YMPQNRQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKF-YDAPYEYELMLKC 1505
Query: 2500 FDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSF----VLRTDAM 2667
+ FTS+F++E LK+I FG++ ++ R+A+N+ D + V S+T + T+
Sbjct: 1506 LNIVFTSMFSMECVLKIIAFGVL----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNF 1561
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
+ + ++ ++ + + K + + L+ ML F++AIIG+Q+F
Sbjct: 1562 INLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1621
Query: 2848 KGTFFLCNDLS 2880
G L +D S
Sbjct: 1622 -GNIALDDDTS 1631
Score = 70.1 bits (170), Expect = 6e-10
Identities = 52/205 (25%), Positives = 87/205 (42%), Gaps = 8/205 (3%)
Frame = +1
Query: 1525 NLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYF-DLMKPLGVSV 1701
N+ F +FSME +LK+ + G Y +N FD V+ SI + ++ + + +S
Sbjct: 1507 NIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSF 1566
Query: 1702 LRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFN 1881
LR R R+ K+ + GMQVFG
Sbjct: 1567 LRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIAL 1626
Query: 1882 FNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMY-----HGIESFGGVGTLGVIVCIY 2046
+ NF TF+QAL+ +F+ TGE W+ +M + G +
Sbjct: 1627 DDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACDEQANATECGSDFAYF 1686
Query: 2047 YIV--LFICGNYILLNVFLAIAVDN 2115
Y V +F+C ++++LN+F+A+ +DN
Sbjct: 1687 YFVSFIFLC-SFLMLNLFVAVIMDN 1710
Score = 57.0 bits (136), Expect = 5e-06
Identities = 58/267 (21%), Positives = 110/267 (40%), Gaps = 6/267 (2%)
Frame = +1
Query: 2293 AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSS---AMLAAEDPL 2463
A +++K SS + FR F +V F VL + +++ AM+ P
Sbjct: 449 ARASLKSGKTESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPR 508
Query: 2464 QANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTS 2643
+ +T L + ++ F +F E++LK+ G S+ R++FN D V+ S+
Sbjct: 509 RLTTT----LYFAEFVFLGLFLTEMSLKMYGLG----PRSYFRSSFNCFDFGVIVGSVFE 560
Query: 2644 FVLRTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQ 2814
V K L+++V ++ ++K+I +++ + F+
Sbjct: 561 VVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFI 620
Query: 2815 FMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDN 2994
+FA++G+QLF G F +++D PT NFD
Sbjct: 621 VVFALLGMQLFGGQF-------------------NFQDETPTT-------------NFDT 648
Query: 2995 VGDAMISLFVVSTFEGWPQLLYVAIDS 3075
A++++F + T E W ++Y I+S
Sbjct: 649 FPAAILTVFQILTGEDWNAVMYHGIES 675
>gi|1705855|sp|Q02294|CCAB_RAT Voltage-dependent N-type calcium
channel alpha-1B subunit (Voltage-gated calcium channel
alpha subunit Cav2.2) (Calcium channel, L type, alpha-1
polypeptide isoform 5) (Brain calcium channel III) (BIII)
gi|206572|gb|AAA42014.1| calcium channel alpha-1 subunit
Length = 2336
Score = 665 bits (1715), Expect = 0.0
Identities = 353/787 (44%), Positives = 491/787 (61%), Gaps = 15/787 (1%)
Frame = +1
Query: 2308 KPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNM 2487
+PI SS+F LS TN R FC+ +V YF +L I +SS LAAEDP++ +S RN
Sbjct: 1120 RPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEMVILVVIALSSIALAAEDPVRTDSFRNN 1179
Query: 2488 ILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRT--- 2658
L Y DY FT VFT E+ +K+I GL+ H G++ R+ +N+LD +VV+ +L +F +
Sbjct: 1180 ALKYMDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSSFMG 1239
Query: 2659 ----DAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFA 2826
++ I R LK V CV+ ++K + NI++V + F+FA
Sbjct: 1240 GSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFA 1299
Query: 2827 IIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDA 3006
+I VQLFKG FF C D SK E +CRG+Y+ YE + ++ R W DF++DNV A
Sbjct: 1300 VIAVQLFKGKFFYCTDESKELERDCRGQYLDYEKEEVE---AQPRQWKKYDFHYDNVLWA 1356
Query: 3007 MISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGF 3186
+++LF VST EGWP +L ++D+ E++GP R +++
Sbjct: 1357 LLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGFRMELSIFYVVYFVVFPFFFVNIFVAL 1416
Query: 3187 VIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRAFE 3360
+I+TFQ +G++ C L+KN+R CI+FA+ AKP RY+P+N+ QY+ W FV S FE
Sbjct: 1417 IIITFQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNKQSFQYKTWTFVVSPPFE 1476
Query: 3361 YVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDR 3540
Y I +I +NTV L K Y + +E L N++FT +F+ E +LKI+A NY D
Sbjct: 1477 YFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSLECILKIIAFGVLNYFRDA 1536
Query: 3541 WNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFM 3720
WNVFD + V+GS DI ++ N I+++F RLFR RL+KL +G IR LLWTF+
Sbjct: 1537 WNVFDFVTVLGSITDILVTEI---ANNFINLSFLRLFRAARLIKLCRQGYTIRILLWTFV 1593
Query: 3721 KSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSAT 3900
+SF+ALPYV LLI +LFFIYA+IGMQ FG +ALDD TSI+R+NNF +F A+++LFRSAT
Sbjct: 1594 QSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDGTSINRHNNFRTFLQALMLLFRSAT 1653
Query: 3901 GEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLF 4080
GEAW +IMLSC CDP + N S CG++FAY YF+SF LCSFL++NLF
Sbjct: 1654 GEAWHEIMLSCLGNR--ACDPHA--------NASECGSDFAYFYFVSFIFLCSFLMLNLF 1703
Query: 4081 VAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFG 4260
VAVIMDNF+YLTRD SILGPHHL+EF+R+W+EYDP A GRI + D+ +L+ +SPPLG G
Sbjct: 1704 VAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLG 1763
Query: 4261 KLCPHRLACKRLVSMNMPL-NSDGTVCFNATLFALVRTNLKIY---TEGNIDEANEQLRS 4428
K CP R+A KRLV MNMP+ N D TV F +TL AL+RT L+I + + +LR
Sbjct: 1764 KKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALIRTALEIKLAPAGTKQHQCDAELRK 1823
Query: 4429 AIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEM--EAKGVLP 4602
I +W + LD +VPP K D++TVGK YA +I D++++ K ++ +A G L
Sbjct: 1824 EISSVWANLPQKTLDLLVPP-HKPDEMTVGKVYAALMIFDFYKQNKTTRDQTHQAPGGLS 1882
Query: 4603 AQTPQAM 4623
P ++
Sbjct: 1883 QMGPVSL 1889
Score = 509 bits (1310), Expect = e-142
Identities = 291/665 (43%), Positives = 374/665 (55%), Gaps = 25/665 (3%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N +RK I EW PFE++IL I ANCI LA+ Q P D + L+ E FI +
Sbjct: 81 DNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGI 140
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KI+A+GF+FH +YLRN WN++DF++V+ +++T + FD++ LRA R
Sbjct: 141 FCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTEILATAGTD-----FDLRTLRAVR 195
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQVVL +I++AM+PLL I LL+ F IL++AIIGLE + GK H C
Sbjct: 196 VLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFP 255
Query: 760 PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFG 939
+T D P G G + DS T EC WPGPN GITNFDN
Sbjct: 256 NST------DAEPVGDFPCGKEAPARLCDSDT------ECREY--WPGPNFGITNFDNIL 301
Query: 940 LAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSK 1119
A+LTVFQC+++EGWTD++Y NDA G W W+YF+ L+I+GSFF+LNLVLGVLSGEF+K
Sbjct: 302 FAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAK 361
Query: 1120 EREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDE--QEDEPVAQTXXXXX 1293
ERE+ R F K R +QQ+E +L GYL+WI +AE++ ED+ +E P+
Sbjct: 362 ERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDKNAEEKSPLDAVLKRAA 421
Query: 1294 XXXX-----------------------XXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXX 1404
++ ++ +R EK+
Sbjct: 422 TKKSRNDLIHAEEGEDRFVDLCAAGSPFARASLKSGKTESSSYFRRKEKM---FRFLIRR 478
Query: 1405 LVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLG 1584
+VK+Q+FYW HY Q + L A F+ LF EM LKMY LG
Sbjct: 479 MVKAQSFYWVVLCVVALNTLCVAMVHYNQPQRLTTALYFAEFVFLGLFLTEMSLKMYGLG 538
Query: 1585 FTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXX 1764
+Y S FN FD V++ SI E V G+SVLR+ RLLRIFKVTKYW
Sbjct: 539 PRSYFRSSFNCFDFGVIVGSIFEVVWAAIKPGTSFGISVLRALRLLRIFKVTKYWNSLRN 598
Query: 1765 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLT 1944
GMQ+FGG+FNF Q P NFDTF A+LT
Sbjct: 599 LVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF--QDETPTTNFDTFPAAILT 656
Query: 1945 VFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLAD 2124
VFQILTGEDWN VMYHGIES GGV + G+ Y+IVL + GNY LLNVFLAIAVDNLA+
Sbjct: 657 VFQILTGEDWNAVMYHGIESQGGV-SKGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLAN 715
Query: 2125 ADSLT 2139
A LT
Sbjct: 716 AQELT 720
Score = 134 bits (336), Expect = 3e-29
Identities = 94/326 (28%), Positives = 164/326 (49%), Gaps = 14/326 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
N +R+ C IV + FE +IL +I + IALA P + ++N L+ ++Y+F VF
Sbjct: 1135 NLLRRFCHYIVTMRYFEMVILVVIALSSIALAAEDP--VRTDSFRNNALKYMDYIFTGVF 1192
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKM--SIQGFD---VKAL 567
T E V+K++ +G + HP AY R+ WNILDFI+V LV+ S +G D +K+L
Sbjct: 1193 TFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSSFMGGSKGKDINTIKSL 1252
Query: 568 RAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHS 747
R RVLRPL+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF GK
Sbjct: 1253 RVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF- 1311
Query: 748 TCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNF 927
C D + + ++D D E + QP +W+ ++
Sbjct: 1312 YCTDES--KELERDCRGQYLDYEKEEVEAQPR--------QWKKYD-----------FHY 1350
Query: 928 DNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWP---------WIYFVTLVILGSFFVL 1080
DN A+LT+F + EGW V+ DA E I++V ++ FF +
Sbjct: 1351 DNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGFRMELSIFYVVYFVVFPFFFV 1410
Query: 1081 NLVLGVLSGEFSKEREKARARGLFQK 1158
N+ + ++ F ++ +K + +K
Sbjct: 1411 NIFVALIIITFQEQGDKVMSECSLEK 1436
Score = 122 bits (305), Expect = 1e-25
Identities = 75/269 (27%), Positives = 136/269 (49%), Gaps = 8/269 (2%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V +++F +V+ ++ +NT+ +A HY + L +F G+F E LK+ L P
Sbjct: 480 VKAQSFYWVVLCVVALNTLCVAMVHYNQPQRLTTALYFAEFVFLGLFLTEMSLKMYGLGP 539
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
++Y +N FD V+VGS ++ + + PG + I+ R R++R+ K+ +R
Sbjct: 540 RSYFRSSFNCFDFGVIVGSIFEVVWAAIKPGTS--FGISVLRALRLLRIFKVTKYWNSLR 597
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + + S +++ + L+ L ++A++GMQ F G+ D T NF +FPAAI
Sbjct: 598 NLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETP---TTNFDTFPAAI 654
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYH----KGGLNESRCGNNFAYPYFISF 4044
L +F+ TGE W +M YH +GG+++ F+ YFI
Sbjct: 655 LTVFQILTGEDWNAVM-----------------YHGIESQGGVSKGM----FSSFYFIVL 693
Query: 4045 FMLCSFLVINLFVAVIMDNF---DYLTRD 4122
+ ++ ++N+F+A+ +DN LT+D
Sbjct: 694 TLFGNYTLLNVFLAIAVDNLANAQELTKD 722
Score = 97.4 bits (241), Expect = 3e-18
Identities = 72/295 (24%), Positives = 133/295 (44%), Gaps = 12/295 (4%)
Frame = +1
Query: 265 PFEFLILFMICANCIALAIYQPYPAQDSDYKNTL-LETIEYVFIVVFTIECVLKIVAMGF 441
PFE+ I+ MI N + L + D+ Y+ L L+ + VF +F++EC+LKI+A G
Sbjct: 1474 PFEYFIMAMIALNTVVLMM----KFYDAPYEYELMLKCLNIVFTSMFSLECILKIIAFGV 1529
Query: 442 MFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSL 621
+ Y R+AWN+ DF+ V+ + ++++++ ++ LR FR R ++L ++
Sbjct: 1530 L----NYFRDAWNVFDFVTVLGSITDILVTEIANNFINLSFLRLFRAARLIKLCRQGYTI 1585
Query: 622 QVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPC 801
+++L +++ L ++ LL+ + IYAIIG+++F G +A D T
Sbjct: 1586 RILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------GNIALDDGTSI 1632
Query: 802 GTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEG 981
N NF F A++ +F+ + E
Sbjct: 1633 ------------------------------------NRHNNFRTFLQALMLLFRSATGEA 1656
Query: 982 WTDVM-----------YWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
W ++M + G ++ + YFV+ + L SF +LNL + V+ F
Sbjct: 1657 WHEIMLSCLGNRACDPHANASECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1711
Score = 90.9 bits (224), Expect = 3e-16
Identities = 72/262 (27%), Positives = 118/262 (44%), Gaps = 13/262 (4%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLF+ S N R + + F +L I+ + +LA E L M L+
Sbjct: 74 SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 133
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV-----AVSLTSFVLRTDAM 2667
+ +F +F E +K+I G VFHKGS+ RN +N++D +VV A + T F LRT
Sbjct: 134 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTEILATAGTDFDLRT--- 190
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
++ L+ V++ ++ A+ + I L+ F MFAIIG++ +
Sbjct: 191 -----LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY 245
Query: 2848 KGTFFLCNDLSKMTEAECRGEYIHYEDGDP---TKPVSKKRVWSNNDF---NFDNVGDAM 3009
G F T+AE G++ ++ + W +F NFDN+ A+
Sbjct: 246 MGKFHKA-CFPNSTDAEPVGDFPCGKEAPARLCDSDTECREYWPGPNFGITNFDNILFAI 304
Query: 3010 ISLFVVSTFEGWPQLLYVAIDS 3075
+++F T EGW +LY D+
Sbjct: 305 LTVFQCITMEGWTDILYNTNDA 326
Score = 87.0 bits (214), Expect = 5e-15
Identities = 79/292 (27%), Positives = 126/292 (43%), Gaps = 42/292 (14%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY+I I+ N + LA + H P + LD F G+F FEA +KI+AL
Sbjct: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WNV D +VV+ L GT+ + R RV+R +KL+S
Sbjct: 157 HKGSYLRNGWNVMDFVVVLTEI-------LATAGTD-FDLRTLRAVRVLRPLKLVSGIPS 208
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF----------------------- 3804
++ +L + MK+ L + LL+ ++A+IG++F+
Sbjct: 209 LQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPC 268
Query: 3805 GKVA---LDDSTSIHRN---------NNFHSFPAAILVLFRSATGEAWQDIMLSCSDRED 3948
GK A L DS + R NF + AIL +F+ T E W DI+ + +D
Sbjct: 269 GKEAPARLCDSDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTND--- 325
Query: 3949 VRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
GN + + YFI ++ SF ++NL + V+ F
Sbjct: 326 ------------------AAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 359
Score = 70.5 bits (171), Expect = 5e-10
Identities = 53/204 (25%), Positives = 87/204 (41%), Gaps = 7/204 (3%)
Frame = +1
Query: 1525 NLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVL 1704
N+ F +FS+E +LK+ + G Y +N FD V+ SI + +LV + +S L
Sbjct: 1509 NIVFTSMFSLECILKIIAFGVLNYFRDAWNVFDFVTVLGSITD-ILVTEIANNFINLSFL 1567
Query: 1705 RSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNF 1884
R R R+ K+ + GMQVFG
Sbjct: 1568 RLFRAARLIKLCRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALD 1627
Query: 1885 NPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMY-----HGIESFGGVGTLGVIVCIYY 2049
+ NF TF+QAL+ +F+ TGE W+ +M + G +Y
Sbjct: 1628 DGTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLGNRACDPHANASECGSDFAYFY 1687
Query: 2050 IV--LFICGNYILLNVFLAIAVDN 2115
V +F+C ++++LN+F+A+ +DN
Sbjct: 1688 FVSFIFLC-SFLMLNLFVAVIMDN 1710
Score = 68.2 bits (165), Expect = 2e-09
Identities = 94/480 (19%), Positives = 182/480 (37%), Gaps = 42/480 (8%)
Frame = +1
Query: 1534 FVILFSMEMLLKMYSLGFTTYTTSQF----NRFDCFVVISSILEFVLVYF-DLMKPLGVS 1698
F +F+ EM++KM LG + + F N D VV +++ F F K ++
Sbjct: 1188 FTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSSFMGGSKGKDIN 1247
Query: 1699 VLRSARLLRIF---KVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFG 1869
++S R+LR+ K K +Q+F
Sbjct: 1248 TIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFK 1307
Query: 1870 GKFNFNPQQPK---------------------PRA------NFDTFVQALLTVFQILTGE 1968
GKF + + K PR ++D + ALLT+F + TGE
Sbjct: 1308 GKFFYCTDESKELERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGE 1367
Query: 1969 DWNTVMYHGI----ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSL 2136
W V+ H + E G + + I+Y+V F+ + +N+F+A+ + +
Sbjct: 1368 GWPMVLKHSVDATYEEQGPSPGFRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDK 1427
Query: 2137 TNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSARPRRMSEVPAASTVKPI 2316
+ S + + A + KP+
Sbjct: 1428 VMSE------------------------------------CSLEKNERACIDFAISAKPL 1451
Query: 2317 PKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMILN 2496
+ ++ + SF+ V F ++ I +++ +L + A ++L
Sbjct: 1452 TR----YMPQNKQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKF-YDAPYEYELMLK 1506
Query: 2497 YFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXX 2676
+ FTS+F++E LK+I FG++ ++ R+A+N+ D + V S+T +L T+ +
Sbjct: 1507 CLNIVFTSMFSLECILKIIAFGVL----NYFRDAWNVFDFVTVLGSITD-ILVTEIANNF 1561
Query: 2677 XXXXXXXXXXXXXAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
I + ++ ++ + + K + + L+ ML F++AIIG+Q+F
Sbjct: 1562 INLSFLRLFRAARLIKLCRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1621
Score = 54.7 bits (130), Expect = 3e-05
Identities = 55/264 (20%), Positives = 104/264 (38%), Gaps = 3/264 (1%)
Frame = +1
Query: 2293 AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN 2472
A +++K SS + FR +V F VL C++ + + A
Sbjct: 450 ARASLKSGKTESSSYFRRKEKMFRFLIRRMVKAQSFYWVVL-CVVALNTLCVAMVHYNQP 508
Query: 2473 STRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL 2652
L + ++ F +F E++LK+ G S+ R++FN D V+ S+ V
Sbjct: 509 QRLTTALYFAEFVFLGLFLTEMSLKMYGLG----PRSYFRSSFNCFDFGVIVGSIFEVVW 564
Query: 2653 RTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
K L+++V ++ ++K+I +++ + F+ +F
Sbjct: 565 AAIKPGTSFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVF 624
Query: 2824 AIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGD 3003
A++G+QLF G F +++D PT NFD
Sbjct: 625 ALLGMQLFGGQF-------------------NFQDETPTT-------------NFDTFPA 652
Query: 3004 AMISLFVVSTFEGWPQLLYVAIDS 3075
A++++F + T E W ++Y I+S
Sbjct: 653 AILTVFQILTGEDWNAVMYHGIES 676
>gi|29789098|ref|NP_062167.1| calcium channel, voltage-dependent, L
type, alpha 1E subunit [Rattus norvegicus]
gi|1705707|sp|Q07652|CCAE_RAT Voltage-dependent R-type calcium
channel alpha-1E subunit (Voltage-gated calcium channel
alpha subunit Cav2.3) (Calcium channel, L type, alpha-1
polypeptide, isoform 6) (RBE-II) (RBE2) (Brain calcium
channel II) (BII)
gi|476782|pir||A37490 voltage-dependent calcium channel alpha 1E -
rat
gi|310083|gb|AAA40855.1| voltage-activated calcium channel alpha-1
subunit
Length = 2222
Score = 664 bits (1714), Expect = 0.0
Identities = 354/774 (45%), Positives = 484/774 (61%), Gaps = 13/774 (1%)
Frame = +1
Query: 2302 TVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR 2481
T K + SS+FI S TN R C+ +VN YF +L I SS LAAEDP+ NS R
Sbjct: 1075 TGKAMVPHSSMFIFSTTNPIRKACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSER 1134
Query: 2482 NMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTD 2661
N +L YFDY FT VFT E+ +K+I GL+ GS+ R+ +N+LD +VV +L +F L
Sbjct: 1135 NKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANA 1194
Query: 2662 A-------MSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFM 2820
+ I R LK V CV+ ++K + NI++V + F+
Sbjct: 1195 LGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFI 1254
Query: 2821 FAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVG 3000
FA+I VQLFKG FF C D SK TE EC G Y+ +E K K R W ++F++DN+
Sbjct: 1255 FAVIAVQLFKGKFFYCTDSSKDTEKECIGNYVDHEKN---KMEVKGREWKRHEFHYDNII 1311
Query: 3001 DAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXX 3180
A+++LF VST EGWPQ+L ++D EED+GP ++R +++
Sbjct: 1312 WALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFV 1371
Query: 3181 GFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRA 3354
+I+TFQ +G++ E C L+KN+R CI+FA+ AKP RY+P+NR QYRVW FV S +
Sbjct: 1372 ALIIITFQEQGDKMMEECSLEKNERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPS 1431
Query: 3355 FEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYIS 3534
FEY I +I +NTV L K+Y + +E L N+ FT VF+ E VLK++A NY
Sbjct: 1432 FEYTIMAMIALNTVVLMMKYYSAPWTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFR 1491
Query: 3535 DRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWT 3714
D WN+FD + V+GS +I T+ +++F +LFR RL+KLL +G IR LLWT
Sbjct: 1492 DTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWT 1551
Query: 3715 FMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRS 3894
F++SF+ALPYV LLI +LFFIYA+IGMQ FG + LD+ + I+R+NNF SF ++++LFRS
Sbjct: 1552 FVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRS 1611
Query: 3895 ATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNES-RCGNNFAYPYFISFFMLCSFLVI 4071
ATGEAWQ+IMLSC + C+P D G NES RCG + AY YF+SF CSFL++
Sbjct: 1612 ATGEAWQEIMLSCLGEKG--CEP--DTTAPSGQNESERCGTDLAYVYFVSFIFFCSFLML 1667
Query: 4072 NLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPL 4251
NLFVAVIMDNF+YLTRD SILGPHHL+EFVR+W+EYD A GRI + ++ +L +SPPL
Sbjct: 1668 NLFVAVIMDNFEYLTRDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPL 1727
Query: 4252 GFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKI-YTEGNID--EANEQL 4422
G GK CP ++A KRLV MNMP+ D TV F +TL AL+RT L I +G D + + +L
Sbjct: 1728 GLGKRCPSKVAYKRLVLMNMPVAEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSEL 1787
Query: 4423 RSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEME 4584
+ IW + +LD +V P K D+TVGK YA +I DY+++ K +K+ +
Sbjct: 1788 QKETLAIWPHLSQKMLDLLV-PMPKASDLTVGKIYAAMMIMDYYKQSKVKKQRQ 1840
Score = 515 bits (1326), Expect = e-144
Identities = 286/667 (42%), Positives = 374/667 (55%), Gaps = 27/667 (4%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N +RK +++W PFE++IL I ANCI LA+ Q P D + LE E FI +
Sbjct: 26 DNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGI 85
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KIVA+GF+FH +YLRN WN++DFI+V+ G+++T + + D++ LRA R
Sbjct: 86 FCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTH-VDLRTLRAVR 144
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQ+VL +I++AM+PLL I LL+ F IL++AIIGLE + GKLH C
Sbjct: 145 VLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFM 204
Query: 760 PATGQLAQKDPT-PCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNF 936
+G L DP PCG + ++C+ W GPN+GIT FDN
Sbjct: 205 NNSGILEGFDPPHPCGVQGCPAGYECKD------------------WIGPNDGITQFDNI 246
Query: 937 GLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFS 1116
A+LTVFQC+++EGWT V+Y NDA+G W W+YF+ L+I+GSFFVLNLVLGVLSGEF+
Sbjct: 247 LFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFA 306
Query: 1117 KEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNED---------------- 1248
KERE+ R F K R +QQ+E +L GY WI +AE++ E+
Sbjct: 307 KERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNSGTSALEVLRRATI 366
Query: 1249 ----------EQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXX 1398
+ DE + + +RL +++
Sbjct: 367 KRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSTKVDGASYFRHKERLLRIS------I 420
Query: 1399 XXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYS 1578
+VKSQ FYW H+ Q +WL H A F+ LF +EM LKMY
Sbjct: 421 RHMVKSQVFYWIVLSVVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYG 480
Query: 1579 LGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXX 1758
+G Y S FN FD V + SI E V F G+SVLR+ RLLRIFK+TKYW
Sbjct: 481 MGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASL 540
Query: 1759 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQAL 1938
GMQ+FGG+FNFN P ANFDTF A+
Sbjct: 541 RNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFN--DGTPSANFDTFPAAI 598
Query: 1939 LTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNL 2118
+TVFQILTGEDWN VMY+GI S GGV + G+ IY+IVL + GNY LLNVFLAIAVDNL
Sbjct: 599 MTVFQILTGEDWNEVMYNGIRSQGGVSS-GMWSAIYFIVLTLFGNYTLLNVFLAIAVDNL 657
Query: 2119 ADADSLT 2139
A+A LT
Sbjct: 658 ANAQELT 664
Score = 131 bits (330), Expect = 2e-28
Identities = 102/378 (26%), Positives = 172/378 (44%), Gaps = 14/378 (3%)
Frame = +1
Query: 139 KRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIALA 318
++ Q+K R+T NPIRK C IV + FE IL +I A+ IALA
Sbjct: 1064 EKKKQKKEKRETGKAMVPHSSMFIFSTTNPIRKACHYIVNLRYFEMCILLVIAASSIALA 1123
Query: 319 IYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFII 498
P +N +L +YVF VFT E V+K++ G + +Y R+ WNILDF++
Sbjct: 1124 AEDPVLTNSE--RNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVV 1181
Query: 499 VVIGLVSTILSKM--SIQGFD---VKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPL 663
VV LV+ L+ + +G D +K+LR RVLRPL+ + +P L+ V + ++ ++ +
Sbjct: 1182 VVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNV 1241
Query: 664 LHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPS 843
+I ++ + I+A+I ++LF GK C D + DTE
Sbjct: 1242 FNILIVYKLFMFIFAVIAVQLFKGKFF-YCTDSS-------------KDTEKECIGNYVD 1287
Query: 844 DSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAV-- 1017
M V+ W ++DN A+LT+F + EGW V+ D
Sbjct: 1288 HEKNKMEVK-----GREW---KRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEE 1339
Query: 1018 -------GREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQQ 1176
R I++V ++ FF +N+ + ++ F ++ + K E+
Sbjct: 1340 DRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGD---------KMMEECS 1390
Query: 1177 LEEDLKGYLDWITQAEDI 1230
LE++ + +D+ A+ +
Sbjct: 1391 LEKNERACIDFAISAKPL 1408
Score = 116 bits (290), Expect = 7e-24
Identities = 72/273 (26%), Positives = 137/273 (49%), Gaps = 4/273 (1%)
Frame = +1
Query: 3316 LQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAV 3495
L+ + V S+ F +++ ++ +NT +A H+ + L +F G+F E
Sbjct: 416 LRISIRHMVKSQVFYWIVLSVVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMS 475
Query: 3496 LKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKL 3675
LK+ + P+ Y +N FD V VGS ++ + PG + I+ R R++R+ K+
Sbjct: 476 LKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTS--FGISVLRALRLLRIFKI 533
Query: 3676 LSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNN 3852
+R L+ + M S +++ + L+ L ++A++GMQ F G+ +D T + N
Sbjct: 534 TKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTP---SAN 590
Query: 3853 FHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPY 4032
F +FPAAI+ +F+ TGE W ++M + +R +GG++ ++ Y
Sbjct: 591 FDTFPAAIMTVFQILTGEDWNEVMYN-----GIR--------SQGGVSSGM----WSAIY 633
Query: 4033 FISFFMLCSFLVINLFVAVIMDNF---DYLTRD 4122
FI + ++ ++N+F+A+ +DN LT+D
Sbjct: 634 FIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 666
Score = 87.4 bits (215), Expect = 4e-15
Identities = 74/303 (24%), Positives = 133/303 (43%), Gaps = 21/303 (6%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+ I+ MI N + L + Y + Y+ L+ + F +VF++ECVLK++A GF+
Sbjct: 1432 FEYTIMAMIALNTVVLMM--KYYSAPWTYE-LALKYLNIAFTMVFSLECVLKVIAFGFL- 1487
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMSI---QGFDVKALRAFRVLRPLRLVSGVPS 618
Y R+ WNI DFI V+ + IL+ + GF++ L+ FR R ++L+ +
Sbjct: 1488 ---NYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYT 1544
Query: 619 LQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTP 798
++++L +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1545 IRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF----------------------- 1581
Query: 799 CGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLE 978
N+ + E N +N +F FG ML +F+ + E
Sbjct: 1582 ------------------GNIKLDEESHINR-----HNNFRSF--FGSLML-LFRSATGE 1615
Query: 979 GWTDVMYWV------------------NDAVGREWPWIYFVTLVILGSFFVLNLVLGVLS 1104
W ++M ++ G + ++YFV+ + SF +LNL + V+
Sbjct: 1616 AWQEIMLSCLGEKGCEPDTTAPSGQNESERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIM 1675
Query: 1105 GEF 1113
F
Sbjct: 1676 DNF 1678
Score = 85.9 bits (211), Expect = 1e-14
Identities = 80/346 (23%), Positives = 152/346 (43%), Gaps = 9/346 (2%)
Frame = +1
Query: 232 RKLCISI---VEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
R L ISI V+ + F +++L ++ N +AI Q + LL E++F+ +F
Sbjct: 414 RLLRISIRHMVKSQVFYWIVLSVVALNTACVAIVHHNQPQ---WLTHLLYYAEFLFLGLF 470
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKALRAF 576
+E LK+ MG P Y +++N DF + V G + ++ + G F + LRA
Sbjct: 471 LLEMSLKMYGMG----PRLYFHSSFNCFDFGVTV-GSIFEVVWAIFRPGTSFGISVLRAL 525
Query: 577 RVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI 756
R+LR ++ SL+ ++ +++ +M ++ + L+ I+++A++G++LF G+ +
Sbjct: 526 RLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFN-- 583
Query: 757 DPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNF 936
D TP NFD F
Sbjct: 584 ----------DGTPSA---------------------------------------NFDTF 594
Query: 937 GLAMLTVFQCVSLEGWTDVMYWVNDAVG----REWPWIYFVTLVILGSFFVLNLVLGVLS 1104
A++TVFQ ++ E W +VMY + G W IYF+ L + G++ +LN+ L +
Sbjct: 595 PAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAIYFIVLTLFGNYTLLNVFLAIAV 654
Query: 1105 GEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVN 1242
+ Q+ + +Q EE+ + +A+++ P++
Sbjct: 655 DNLANA----------QELTKDEQEEEEAFNQKHALQKAKEVSPMS 690
Score = 79.0 bits (193), Expect = 1e-12
Identities = 68/267 (25%), Positives = 114/267 (42%), Gaps = 18/267 (6%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLFI N R + +++ F +L I+ + +LA E L + M L
Sbjct: 19 SLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT 78
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV-----AVSLTSFVLRTDAM 2667
+ +F +F E +K++ G +FHKGS+ RN +N++D +VV A + T F D
Sbjct: 79 EPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLR 138
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
+ ++ L+ V++ ++ A+ + I L+ F MFAIIG++ +
Sbjct: 139 T----LRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY 194
Query: 2848 KGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVS----------KKRVWSNNDF-NFDN 2994
G K+ A E DP P K + N+ FDN
Sbjct: 195 SG---------KLHRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDN 245
Query: 2995 VGDAMISLFVVSTFEGWPQLLYVAIDS 3075
+ A++++F T EGW +LY D+
Sbjct: 246 ILFAVLTVFQCITMEGWTTVLYNTNDA 272
Score = 78.2 bits (191), Expect = 2e-12
Identities = 104/484 (21%), Positives = 184/484 (37%), Gaps = 46/484 (9%)
Frame = +1
Query: 1534 FVILFSMEMLLKMYSLGFTTYTTSQF----NRFDCFVVISSILEFVLVY-FDLMKPLGVS 1698
F +F+ EM++KM G S F N D VV+ +++ F L K +
Sbjct: 1145 FTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIK 1204
Query: 1699 VLRSARLLRIF---KVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFG 1869
++S R+LR+ K K +Q+F
Sbjct: 1205 TIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFK 1264
Query: 1870 GKFNF---------------------NPQQPKPRA------NFDTFVQALLTVFQILTGE 1968
GKF + N + K R ++D + ALLT+F + TGE
Sbjct: 1265 GKFFYCTDSSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGE 1324
Query: 1969 DWNTVMYHGI----ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLAD-ADS 2133
W V+ H + E G + + + I+Y+V F+ + +N+F+A+ + + D
Sbjct: 1325 GWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDK 1384
Query: 2134 LTNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSARPRRMSEVPAASTVKP 2313
+ S + + A + KP
Sbjct: 1385 MMEE-------------------------------------CSLEKNERACIDFAISAKP 1407
Query: 2314 IPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMIL 2493
+ + HT +RV+ + VV+ S F ++ I +++ +L + A T + L
Sbjct: 1408 LTRYMPQ--NRHTFQYRVW-HFVVSPS-FEYTIMAMIALNTVVLMMK-YYSAPWTYELAL 1462
Query: 2494 NYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSX 2673
Y + FT VF++E LKVI FG + ++ R+ +N+ D + V S+T +L TD+
Sbjct: 1463 KYLNIAFTMVFSLECVLKVIAFGFL----NYFRDTWNIFDFITVIGSITEIIL-TDSKLV 1517
Query: 2674 XXXXXXXXXXXXXXAINRAKGLKH------VVQCVIVAVKTIGNIMLVTFMLQFMFAIIG 2835
A K L+ ++ + + K + + L+ ML F++AIIG
Sbjct: 1518 NTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIG 1577
Query: 2836 VQLF 2847
+Q+F
Sbjct: 1578 MQVF 1581
Score = 77.8 bits (190), Expect = 3e-12
Identities = 116/586 (19%), Positives = 204/586 (34%), Gaps = 71/586 (12%)
Frame = +1
Query: 1531 FFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVS 1698
+F+ +F E +K+ +LGF +Y + +N D VV+S IL +F+ L
Sbjct: 81 YFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDL--R 138
Query: 1699 VLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF 1878
LR+ R+LR K+ G++ + GK
Sbjct: 139 TLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKL 198
Query: 1879 N-------------FNPQQP-------------------KPRANFDTFVQALLTVFQILT 1962
+ F+P P FD + A+LTVFQ +T
Sbjct: 199 HRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCIT 258
Query: 1963 GEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLA------- 2121
E W TV+Y+ ++ G +Y+I L I G++ +LN+ L + A
Sbjct: 259 MEGWTTVLYNTNDALGATWNW-----LYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVE 313
Query: 2122 ------------DADSLTNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSA 2265
+ N T A
Sbjct: 314 NRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNSGTSALEVLRRATIKRSRTEA 373
Query: 2266 RPRRMSE---VPAASTVKPIPKAS--------SLFILSHTNSFRVFCNMVVNHSYFTNAV 2412
R S+ V +S P+ +AS + + R+ +V F V
Sbjct: 374 MTRDSSDEHCVDISSVGTPLARASIKSTKVDGASYFRHKERLLRISIRHMVKSQVFYWIV 433
Query: 2413 LFCILVSSAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFG--LVFHKGSF 2586
L + +++A +A Q ++ L Y ++ F +F +E++LK+ G L FH
Sbjct: 434 LSVVALNTACVAIVHHNQPQWLTHL-LYYAEFLFLGLFLLEMSLKMYGMGPRLYFH---- 488
Query: 2587 CRNAFNLLDILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQC 2757
++FN D V S+ V K L+++V
Sbjct: 489 --SSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVS 546
Query: 2758 VIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDP 2937
++ ++K+I +++ + F+ +FA++G+QLF G F ++ DG P
Sbjct: 547 LMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF-------------------NFNDGTP 587
Query: 2938 TKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
+ NFD A++++F + T E W +++Y I S
Sbjct: 588 SA-------------NFDTFPAAIMTVFQILTGEDWNEVMYNGIRS 620
Score = 77.8 bits (190), Expect = 3e-12
Identities = 75/303 (24%), Positives = 124/303 (40%), Gaps = 53/303 (17%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACKHY-------PSSRGFEDFLDVFNLIFTGVFAFEAVLKIVAL 3513
FEY+I I+ N + LA + + P SR E F G+F FEA +KIVAL
Sbjct: 42 FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT----EPYFIGIFCFEAGIKIVAL 97
Query: 3514 ----NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNL---ISINFFRLFRVMRLVK 3672
+ +Y+ + WNV D +VV+ G L GT+ + + R RV+R +K
Sbjct: 98 GFIFHKGSYLRNGWNVMDFIVVLS-------GILATAGTHFNTHVDLRTLRAVRVLRPLK 150
Query: 3673 LLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHR--- 3843
L+S ++ +L + MK+ L + LL+ ++A+IG++F+ S +HR
Sbjct: 151 LVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY-------SGKLHRACF 203
Query: 3844 -NNN-----------------------------------FHSFPAAILVLFRSATGEAWQ 3915
NN+ F + A+L +F+ T E W
Sbjct: 204 MNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWT 263
Query: 3916 DIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIM 4095
++ + +D G + + YFI ++ SF V+NL + V+
Sbjct: 264 TVLYNTND---------------------ALGATWNWLYFIPLIIIGSFFVLNLVLGVLS 302
Query: 4096 DNF 4104
F
Sbjct: 303 GEF 305
Score = 66.2 bits (160), Expect = 9e-09
Identities = 52/214 (24%), Positives = 86/214 (39%), Gaps = 17/214 (7%)
Frame = +1
Query: 1525 NLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLG--VS 1698
N+ F ++FS+E +LK+ + GF Y +N FD VI SI E +L L+ G +S
Sbjct: 1466 NIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMS 1525
Query: 1699 VLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF 1878
L+ R R+ K+ + GMQVFG
Sbjct: 1526 FLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIK 1585
Query: 1879 NFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFG---------------G 2013
NF +F +L+ +F+ TGE W +M + G
Sbjct: 1586 LDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQNESER 1645
Query: 2014 VGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDN 2115
GT + +Y++ ++++LN+F+A+ +DN
Sbjct: 1646 CGT--DLAYVYFVSFIFFCSFLMLNLFVAVIMDN 1677
>gi|6753230|ref|NP_033912.1| calcium channel, voltage-dependent, R
type, alpha 1E subunit; calcium channel,
voltage-dependent, L type, alpha 1E subunit; calcium
channel, L type, alpha-1 polypeptide, isoform 6; brain
calcium channel II; BII [Mus musculus]
gi|5921699|sp|Q61290|CCAE_MOUSE Voltage-dependent R-type calcium
channel alpha-1E subunit (Voltage-gated calcium channel
alpha subunit Cav2.3) (Calcium channel, L type, alpha-1
polypeptide, isoform 6) (Brain calcium channel II) (BII)
gi|1083565|pir||C54972 voltage-dependent calcium channel alpha 1E -
mouse
gi|522331|gb|AAA59206.1| voltage-dependent calcium channel
Length = 2272
Score = 664 bits (1713), Expect = 0.0
Identities = 354/774 (45%), Positives = 484/774 (61%), Gaps = 13/774 (1%)
Frame = +1
Query: 2302 TVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR 2481
T K + SS+FI S TN R C+ +VN YF +L I SS LAAEDP+ NS R
Sbjct: 1126 TGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSER 1185
Query: 2482 NMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTD 2661
N +L YFDY FT VFT E+ +K+I GL+ GS+ R+ +N+LD +VV +L +F L
Sbjct: 1186 NKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANA 1245
Query: 2662 A-------MSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFM 2820
+ I R LK V CV+ ++K + NI++V + F+
Sbjct: 1246 LGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFI 1305
Query: 2821 FAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVG 3000
FA+I VQLFKG FF C D SK TE EC G Y+ +E K K R W ++F++DN+
Sbjct: 1306 FAVIAVQLFKGKFFYCTDSSKDTEKECIGNYVDHEKN---KMEVKGREWKRHEFHYDNII 1362
Query: 3001 DAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXX 3180
A+++LF VST EGWPQ+L ++D EED+GP ++R +++
Sbjct: 1363 WALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFV 1422
Query: 3181 GFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRA 3354
+I+TFQ +G++ E C L+KN+R CI+FA+ AKP RY+P+NR QYRVW FV S +
Sbjct: 1423 ALIIITFQEQGDKMMEECSLEKNERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPS 1482
Query: 3355 FEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYIS 3534
FEY I +I +NTV L K+Y + +E L N+ FT VF+ E VLK++A NY
Sbjct: 1483 FEYTIMAMIALNTVVLMMKYYTAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFR 1542
Query: 3535 DRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWT 3714
D WN+FD + V+GS +I T+ +++F +LFR RL+KLL +G IR LLWT
Sbjct: 1543 DTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWT 1602
Query: 3715 FMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRS 3894
F++SF+ALPYV LLI +LFFIYA+IGMQ FG + LD+ + I+R+NNF SF ++++LFRS
Sbjct: 1603 FVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRS 1662
Query: 3895 ATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNES-RCGNNFAYPYFISFFMLCSFLVI 4071
ATGEAWQ+IMLSC + C+P D G NES RCG + AY YF+SF CSFL++
Sbjct: 1663 ATGEAWQEIMLSCLGEKG--CEP--DTTAPSGQNESERCGTDLAYVYFVSFIFFCSFLML 1718
Query: 4072 NLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPL 4251
NLFVAVIMDNF+YLTRD SILGPHHL+EFVR+W+EYD A GRI + ++ +L +SPPL
Sbjct: 1719 NLFVAVIMDNFEYLTRDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPL 1778
Query: 4252 GFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKI-YTEGNID--EANEQL 4422
G GK CP ++A KRLV MNMP+ D TV F +TL AL+RT L I +G D + + +L
Sbjct: 1779 GLGKRCPSKVAYKRLVLMNMPVAEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSEL 1838
Query: 4423 RSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEME 4584
+ IW + +LD +V P K D+TVGK YA +I DY+++ K +K+ +
Sbjct: 1839 QKETLAIWPHLSQKMLDLLV-PMPKASDLTVGKIYAAMMIMDYYKQSKVKKQRQ 1891
Score = 516 bits (1330), Expect = e-144
Identities = 287/667 (43%), Positives = 375/667 (56%), Gaps = 27/667 (4%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N +RK +++W PFE++IL I ANCI LA+ Q P D + LE E FI +
Sbjct: 76 DNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGI 135
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KIVA+GF+FH +YLRN WN++DFI+V+ G+++T + + D++ALRA R
Sbjct: 136 FCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTH-VDLRALRAVR 194
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQ+VL +I++AM+PLL I LL+ F IL++AIIGLE + GKLH C
Sbjct: 195 VLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFM 254
Query: 760 PATGQLAQKDPT-PCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNF 936
+G L DP PCG + ++C+ W GPN+GIT FDN
Sbjct: 255 NNSGILEGFDPPHPCGVQGCPAGYECKD------------------WIGPNDGITQFDNI 296
Query: 937 GLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFS 1116
A+LTVFQC+++EGWT V+Y NDA+G W W+YF+ L+I+GSFFVLNLVLGVLSGEF+
Sbjct: 297 LFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFA 356
Query: 1117 KEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNED---------------- 1248
KERE+ R F K R +QQ+E +L GY WI +AE++ E+
Sbjct: 357 KERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNSGTSALEVLRRATI 416
Query: 1249 ----------EQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXX 1398
+ DE + + +RL +++
Sbjct: 417 KRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSTKVDGASYFRHKERLLRIS------I 470
Query: 1399 XXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYS 1578
+VKSQ FYW H+ Q +WL H A F+ LF +EM LKMY
Sbjct: 471 RHMVKSQVFYWIVLSVVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYG 530
Query: 1579 LGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXX 1758
+G Y S FN FD V + SI E V F G+SVLR+ RLLRIFK+TKYW
Sbjct: 531 MGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASL 590
Query: 1759 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQAL 1938
GMQ+FGG+FNFN P ANFDTF A+
Sbjct: 591 RNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFN--DGTPSANFDTFPAAI 648
Query: 1939 LTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNL 2118
+TVFQILTGEDWN VMY+GI S GGV + G+ IY+IVL + GNY LLNVFLAIAVDNL
Sbjct: 649 MTVFQILTGEDWNEVMYNGIRSQGGVSS-GMWSAIYFIVLTLFGNYTLLNVFLAIAVDNL 707
Query: 2119 ADADSLT 2139
A+A LT
Sbjct: 708 ANAQELT 714
Score = 132 bits (332), Expect = 1e-28
Identities = 102/379 (26%), Positives = 173/379 (44%), Gaps = 14/379 (3%)
Frame = +1
Query: 136 KKRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIAL 315
+K+ Q+K R+T NPIR+ C IV + FE IL +I A+ IAL
Sbjct: 1114 EKKKKQKKEKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIAL 1173
Query: 316 AIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFI 495
A P +N +L +YVF VFT E V+K++ G + +Y R+ WNILDF+
Sbjct: 1174 AAEDPVLTNSE--RNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFV 1231
Query: 496 IVVIGLVSTILSKM--SIQGFD---VKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIP 660
+VV LV+ L+ + +G D +K+LR RVLRPL+ + +P L+ V + ++ ++
Sbjct: 1232 VVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKN 1291
Query: 661 LLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQP 840
+ +I ++ + I+A+I ++LF GK C D + DTE
Sbjct: 1292 VFNILIVYKLFMFIFAVIAVQLFKGKFF-YCTDSS-------------KDTEKECIGNYV 1337
Query: 841 SDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAV- 1017
M V+ W ++DN A+LT+F + EGW V+ D
Sbjct: 1338 DHEKNKMEVK-----GREW---KRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTE 1389
Query: 1018 --------GREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQ 1173
R I++V ++ FF +N+ + ++ F ++ + K E+
Sbjct: 1390 EDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGD---------KMMEEC 1440
Query: 1174 QLEEDLKGYLDWITQAEDI 1230
LE++ + +D+ A+ +
Sbjct: 1441 SLEKNERACIDFAISAKPL 1459
Score = 116 bits (290), Expect = 7e-24
Identities = 72/273 (26%), Positives = 137/273 (49%), Gaps = 4/273 (1%)
Frame = +1
Query: 3316 LQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAV 3495
L+ + V S+ F +++ ++ +NT +A H+ + L +F G+F E
Sbjct: 466 LRISIRHMVKSQVFYWIVLSVVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMS 525
Query: 3496 LKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKL 3675
LK+ + P+ Y +N FD V VGS ++ + PG + I+ R R++R+ K+
Sbjct: 526 LKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTS--FGISVLRALRLLRIFKI 583
Query: 3676 LSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNN 3852
+R L+ + M S +++ + L+ L ++A++GMQ F G+ +D T + N
Sbjct: 584 TKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTP---SAN 640
Query: 3853 FHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPY 4032
F +FPAAI+ +F+ TGE W ++M + +R +GG++ ++ Y
Sbjct: 641 FDTFPAAIMTVFQILTGEDWNEVMYN-----GIR--------SQGGVSSGM----WSAIY 683
Query: 4033 FISFFMLCSFLVINLFVAVIMDNF---DYLTRD 4122
FI + ++ ++N+F+A+ +DN LT+D
Sbjct: 684 FIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 716
Score = 87.8 bits (216), Expect = 3e-15
Identities = 74/303 (24%), Positives = 132/303 (43%), Gaps = 21/303 (6%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+ I+ MI N + L + Y Y+ L+ + F +VF++ECVLK++A GF+
Sbjct: 1483 FEYTIMAMIALNTVVLMM--KYYTAPCTYE-LALKYLNIAFTMVFSLECVLKVIAFGFL- 1538
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMSI---QGFDVKALRAFRVLRPLRLVSGVPS 618
Y R+ WNI DFI V+ + IL+ + GF++ L+ FR R ++L+ +
Sbjct: 1539 ---NYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYT 1595
Query: 619 LQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTP 798
++++L +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1596 IRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF----------------------- 1632
Query: 799 CGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLE 978
N+ + E N +N +F FG ML +F+ + E
Sbjct: 1633 ------------------GNIKLDEESHINR-----HNNFRSF--FGSLML-LFRSATGE 1666
Query: 979 GWTDVMYWV------------------NDAVGREWPWIYFVTLVILGSFFVLNLVLGVLS 1104
W ++M ++ G + ++YFV+ + SF +LNL + V+
Sbjct: 1667 AWQEIMLSCLGEKGCEPDTTAPSGQNESERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIM 1726
Query: 1105 GEF 1113
F
Sbjct: 1727 DNF 1729
Score = 85.9 bits (211), Expect = 1e-14
Identities = 80/346 (23%), Positives = 152/346 (43%), Gaps = 9/346 (2%)
Frame = +1
Query: 232 RKLCISI---VEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
R L ISI V+ + F +++L ++ N +AI Q + LL E++F+ +F
Sbjct: 464 RLLRISIRHMVKSQVFYWIVLSVVALNTACVAIVHHNQPQ---WLTHLLYYAEFLFLGLF 520
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKALRAF 576
+E LK+ MG P Y +++N DF + V G + ++ + G F + LRA
Sbjct: 521 LLEMSLKMYGMG----PRLYFHSSFNCFDFGVTV-GSIFEVVWAIFRPGTSFGISVLRAL 575
Query: 577 RVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI 756
R+LR ++ SL+ ++ +++ +M ++ + L+ I+++A++G++LF G+ +
Sbjct: 576 RLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFN-- 633
Query: 757 DPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNF 936
D TP NFD F
Sbjct: 634 ----------DGTPSA---------------------------------------NFDTF 644
Query: 937 GLAMLTVFQCVSLEGWTDVMYWVNDAVG----REWPWIYFVTLVILGSFFVLNLVLGVLS 1104
A++TVFQ ++ E W +VMY + G W IYF+ L + G++ +LN+ L +
Sbjct: 645 PAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAIYFIVLTLFGNYTLLNVFLAIAV 704
Query: 1105 GEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVN 1242
+ Q+ + +Q EE+ + +A+++ P++
Sbjct: 705 DNLANA----------QELTKDEQEEEEAFNQKHALQKAKEVSPMS 740
Score = 79.0 bits (193), Expect = 1e-12
Identities = 68/267 (25%), Positives = 114/267 (42%), Gaps = 18/267 (6%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLFI N R + +++ F +L I+ + +LA E L + M L
Sbjct: 69 SLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT 128
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV-----AVSLTSFVLRTDAM 2667
+ +F +F E +K++ G +FHKGS+ RN +N++D +VV A + T F D
Sbjct: 129 EPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLR 188
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
+ ++ L+ V++ ++ A+ + I L+ F MFAIIG++ +
Sbjct: 189 A----LRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY 244
Query: 2848 KGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVS----------KKRVWSNNDF-NFDN 2994
G K+ A E DP P K + N+ FDN
Sbjct: 245 SG---------KLHRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDN 295
Query: 2995 VGDAMISLFVVSTFEGWPQLLYVAIDS 3075
+ A++++F T EGW +LY D+
Sbjct: 296 ILFAVLTVFQCITMEGWTTVLYNTNDA 322
Score = 78.6 bits (192), Expect = 2e-12
Identities = 104/484 (21%), Positives = 184/484 (37%), Gaps = 46/484 (9%)
Frame = +1
Query: 1534 FVILFSMEMLLKMYSLGFTTYTTSQF----NRFDCFVVISSILEFVLVY-FDLMKPLGVS 1698
F +F+ EM++KM G S F N D VV+ +++ F L K +
Sbjct: 1196 FTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIK 1255
Query: 1699 VLRSARLLRIF---KVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFG 1869
++S R+LR+ K K +Q+F
Sbjct: 1256 TIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFK 1315
Query: 1870 GKFNF---------------------NPQQPKPRA------NFDTFVQALLTVFQILTGE 1968
GKF + N + K R ++D + ALLT+F + TGE
Sbjct: 1316 GKFFYCTDSSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGE 1375
Query: 1969 DWNTVMYHGI----ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLAD-ADS 2133
W V+ H + E G + + + I+Y+V F+ + +N+F+A+ + + D
Sbjct: 1376 GWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDK 1435
Query: 2134 LTNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSARPRRMSEVPAASTVKP 2313
+ S + + A + KP
Sbjct: 1436 MMEE-------------------------------------CSLEKNERACIDFAISAKP 1458
Query: 2314 IPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMIL 2493
+ + HT +RV+ + VV+ S F ++ I +++ +L + A T + L
Sbjct: 1459 LTRYMPQ--NRHTFQYRVW-HFVVSPS-FEYTIMAMIALNTVVLMMK-YYTAPCTYELAL 1513
Query: 2494 NYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSX 2673
Y + FT VF++E LKVI FG + ++ R+ +N+ D + V S+T +L TD+
Sbjct: 1514 KYLNIAFTMVFSLECVLKVIAFGFL----NYFRDTWNIFDFITVIGSITEIIL-TDSKLV 1568
Query: 2674 XXXXXXXXXXXXXXAINRAKGLKH------VVQCVIVAVKTIGNIMLVTFMLQFMFAIIG 2835
A K L+ ++ + + K + + L+ ML F++AIIG
Sbjct: 1569 NTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIG 1628
Query: 2836 VQLF 2847
+Q+F
Sbjct: 1629 MQVF 1632
Score = 77.8 bits (190), Expect = 3e-12
Identities = 116/586 (19%), Positives = 204/586 (34%), Gaps = 71/586 (12%)
Frame = +1
Query: 1531 FFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVS 1698
+F+ +F E +K+ +LGF +Y + +N D VV+S IL +F+ L
Sbjct: 131 YFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDL--R 188
Query: 1699 VLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF 1878
LR+ R+LR K+ G++ + GK
Sbjct: 189 ALRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKL 248
Query: 1879 N-------------FNPQQP-------------------KPRANFDTFVQALLTVFQILT 1962
+ F+P P FD + A+LTVFQ +T
Sbjct: 249 HRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCIT 308
Query: 1963 GEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLA------- 2121
E W TV+Y+ ++ G +Y+I L I G++ +LN+ L + A
Sbjct: 309 MEGWTTVLYNTNDALGATWNW-----LYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVE 363
Query: 2122 ------------DADSLTNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSA 2265
+ N T A
Sbjct: 364 NRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNSGTSALEVLRRATIKRSRTEA 423
Query: 2266 RPRRMSE---VPAASTVKPIPKAS--------SLFILSHTNSFRVFCNMVVNHSYFTNAV 2412
R S+ V +S P+ +AS + + R+ +V F V
Sbjct: 424 MTRDSSDEHCVDISSVGTPLARASIKSTKVDGASYFRHKERLLRISIRHMVKSQVFYWIV 483
Query: 2413 LFCILVSSAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFG--LVFHKGSF 2586
L + +++A +A Q ++ L Y ++ F +F +E++LK+ G L FH
Sbjct: 484 LSVVALNTACVAIVHHNQPQWLTHL-LYYAEFLFLGLFLLEMSLKMYGMGPRLYFH---- 538
Query: 2587 CRNAFNLLDILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQC 2757
++FN D V S+ V K L+++V
Sbjct: 539 --SSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVS 596
Query: 2758 VIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDP 2937
++ ++K+I +++ + F+ +FA++G+QLF G F ++ DG P
Sbjct: 597 LMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF-------------------NFNDGTP 637
Query: 2938 TKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
+ NFD A++++F + T E W +++Y I S
Sbjct: 638 SA-------------NFDTFPAAIMTVFQILTGEDWNEVMYNGIRS 670
Score = 77.8 bits (190), Expect = 3e-12
Identities = 75/303 (24%), Positives = 124/303 (40%), Gaps = 53/303 (17%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACKHY-------PSSRGFEDFLDVFNLIFTGVFAFEAVLKIVAL 3513
FEY+I I+ N + LA + + P SR E F G+F FEA +KIVAL
Sbjct: 92 FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT----EPYFIGIFCFEAGIKIVAL 147
Query: 3514 ----NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNL---ISINFFRLFRVMRLVK 3672
+ +Y+ + WNV D +VV+ G L GT+ + + R RV+R +K
Sbjct: 148 GFIFHKGSYLRNGWNVMDFIVVLS-------GILATAGTHFNTHVDLRALRAVRVLRPLK 200
Query: 3673 LLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHR--- 3843
L+S ++ +L + MK+ L + LL+ ++A+IG++F+ S +HR
Sbjct: 201 LVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY-------SGKLHRACF 253
Query: 3844 -NNN-----------------------------------FHSFPAAILVLFRSATGEAWQ 3915
NN+ F + A+L +F+ T E W
Sbjct: 254 MNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWT 313
Query: 3916 DIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIM 4095
++ + +D G + + YFI ++ SF V+NL + V+
Sbjct: 314 TVLYNTND---------------------ALGATWNWLYFIPLIIIGSFFVLNLVLGVLS 352
Query: 4096 DNF 4104
F
Sbjct: 353 GEF 355
Score = 66.2 bits (160), Expect = 9e-09
Identities = 52/214 (24%), Positives = 86/214 (39%), Gaps = 17/214 (7%)
Frame = +1
Query: 1525 NLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLG--VS 1698
N+ F ++FS+E +LK+ + GF Y +N FD VI SI E +L L+ G +S
Sbjct: 1517 NIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMS 1576
Query: 1699 VLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF 1878
L+ R R+ K+ + GMQVFG
Sbjct: 1577 FLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIK 1636
Query: 1879 NFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFG---------------G 2013
NF +F +L+ +F+ TGE W +M + G
Sbjct: 1637 LDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQNESER 1696
Query: 2014 VGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDN 2115
GT + +Y++ ++++LN+F+A+ +DN
Sbjct: 1697 CGT--DLAYVYFVSFIFFCSFLMLNLFVAVIMDN 1728
>gi|5921693|sp|Q05152|CCAB_RABIT Voltage-dependent N-type calcium
channel alpha-1B subunit (Voltage-gated calcium channel
alpha subunit Cav2.2) (Calcium channel, L type, alpha-1
polypeptide isoform 5) (Brain calcium channel III) (BIII)
gi|217716|dbj|BAA03202.1| calcium channel BIII [Oryctolagus
cuniculus]
Length = 2339
Score = 664 bits (1713), Expect = 0.0
Identities = 361/804 (44%), Positives = 503/804 (61%), Gaps = 13/804 (1%)
Frame = +1
Query: 2308 KPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNM 2487
+PI SS+F LS TN R C+ +V YF +L I +SS LAAEDP++ +S RN
Sbjct: 1127 RPIVPYSSMFCLSPTNLLRRCCHYIVTMRYFEMVILVVIALSSIALAAEDPVRTDSPRNN 1186
Query: 2488 ILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL---RT 2658
L Y DY FT VFT E+ +K+I GL+ H G++ R+ +N+LD +VV+ +L +F +
Sbjct: 1187 ALKYMDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKG 1246
Query: 2659 DAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGV 2838
+S I R LK V CV+ ++K + NI++V + F+FA+I V
Sbjct: 1247 KDISTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAV 1306
Query: 2839 QLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISL 3018
QLFKG FF C D SK E +CRG+Y+ YE + ++ R W DF++DNV A+++L
Sbjct: 1307 QLFKGKFFYCTDESKELERDCRGQYLDYEKEEVE---AQPRQWKKYDFHYDNVLWALLTL 1363
Query: 3019 FVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIVT 3198
F VST EGWP +L ++D+ E++GP R +++ +I+T
Sbjct: 1364 FTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIIT 1423
Query: 3199 FQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRAFEYVIF 3372
FQ +G++ C L+KN+R CI+FA+ A+P RY+P+N+ QY+ W FV S FEY I
Sbjct: 1424 FQEQGDKVMSECSLEKNERACIDFAISARPLTRYMPQNKQSFQYKTWTFVVSPPFEYFIM 1483
Query: 3373 LIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVF 3552
+I +NTV L K Y + +E L N++FT +F+ E VLKI+A NY D WNVF
Sbjct: 1484 AMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVF 1543
Query: 3553 DLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQ 3732
D + V+GS DI ++ N I+++F RLFR RL+KLL +G IR LLWTF++SF+
Sbjct: 1544 DFVTVLGSITDILVTEI---ANNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFK 1600
Query: 3733 ALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAW 3912
ALPYV LLI +LFFIYA+IGMQ FG +ALDD TSI+R+NNF +F A+++LFRSATGEAW
Sbjct: 1601 ALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAW 1660
Query: 3913 QDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVI 4092
+IMLSC CD S N S CG++FAY YF+SF LCSFL++NLFVAVI
Sbjct: 1661 HEIMLSCLSSR--ACDEHS--------NASECGSDFAYFYFVSFIFLCSFLMLNLFVAVI 1710
Query: 4093 MDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCP 4272
MDNF+YLTRD SILGPHHL+EF+R+W+EYDP A GRI + D+ +L+ +SPPLG GK CP
Sbjct: 1711 MDNFEYLTRDSSILGPHHLDEFIRVWAEYDPAACGRISYSDMFEMLKHMSPPLGLGKKCP 1770
Query: 4273 HRLACKRLVSMNMPLNS-DGTVCFNATLFALVRT--NLKIYTEGNID-EANEQLRSAIKR 4440
R+A KRLV MNMP++S D TV F +TL AL+RT ++K+ G + + +LR I
Sbjct: 1771 ARVAYKRLVRMNMPISSEDMTVHFTSTLMALIRTALDIKLAPAGTKQHQCDAELRKEISC 1830
Query: 4441 IWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKE--MEAKGVLPAQTP 4614
+W + LD +VPP K D++TVGK YA +I D++++ K ++ +A G L P
Sbjct: 1831 VWANLPQKTLDLLVPP-HKPDEMTVGKVYAALMIFDFYKQNKTSRDQTQQAPGGLSQLGP 1889
Query: 4615 QAM--ALQAGLRTLHEIGPELKRA 4680
++ L+A TL + P L+ A
Sbjct: 1890 VSLFHPLKA---TLEQTQPALRGA 1910
Score = 505 bits (1301), Expect = e-141
Identities = 288/665 (43%), Positives = 372/665 (55%), Gaps = 25/665 (3%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N +RK I EW PFE++IL I ANCI LA+ Q P D + L+ E FI +
Sbjct: 81 DNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGI 140
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KI+A+GF+ H +YLRN WN++DF++V+ G+++T + FD++ LRA R
Sbjct: 141 FCFEAGIKILALGFVLHKGSYLRNGWNVMDFVVVLTGILATAGTD-----FDLRTLRAVR 195
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQVVL +I++AM+PLL I LL+ F IL++AIIGLE + GK H C
Sbjct: 196 VLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFP 255
Query: 760 PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFG 939
+T DP P G G + + T EC W GPN GITNFDN
Sbjct: 256 NST------DPDPVGDFPCGKEAPARLCEGDT------ECREY--WAGPNFGITNFDNIL 301
Query: 940 LAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSK 1119
A+LTVFQC+++EGWTD++Y NDA G W W+YF+ L+I+GSFF+LNLVLGVLSGEF+K
Sbjct: 302 FAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAK 361
Query: 1120 EREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDE---------------- 1251
ERE+ R F K R +QQ+E +L GYL+WI +AE++ ED
Sbjct: 362 ERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDAVLKRAA 421
Query: 1252 ---------QEDEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXX 1404
Q +E + ++ ++ +R EK+
Sbjct: 422 AKKSRSDLIQAEEGEGRLTGLCAPGSPFARASLKSGKTESSSYFRRKEKM---FRFFIRR 478
Query: 1405 LVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLG 1584
+VK+Q+FYW HY Q + L A F+ LF EM LKMY LG
Sbjct: 479 MVKAQSFYWTVLCVVALNTLCVAMVHYNQPQRLTTALYFAEFVFLGLFLTEMSLKMYGLG 538
Query: 1585 FTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXX 1764
+Y S FN FD V++ SI E V G+SVLR+ RLLRIFKVTKYW
Sbjct: 539 PRSYFRSSFNCFDFGVIVGSIFEVVWAAVKPGTSFGISVLRALRLLRIFKVTKYWNSLRN 598
Query: 1765 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLT 1944
GMQ+FGG+FNF + P NFDTF A+LT
Sbjct: 599 LVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFKDE--TPTTNFDTFPAAILT 656
Query: 1945 VFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLAD 2124
VFQILTGEDWN VMYHGIES GGV + G+ Y+IVL + GNY LLNVFLAIAVDNLA+
Sbjct: 657 VFQILTGEDWNAVMYHGIESQGGV-SRGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLAN 715
Query: 2125 ADSLT 2139
A LT
Sbjct: 716 AQELT 720
Score = 131 bits (329), Expect = 2e-28
Identities = 94/324 (29%), Positives = 163/324 (50%), Gaps = 12/324 (3%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
N +R+ C IV + FE +IL +I + IALA P + +N L+ ++Y+F VF
Sbjct: 1142 NLLRRCCHYIVTMRYFEMVILVVIALSSIALAAEDP--VRTDSPRNNALKYMDYIFTGVF 1199
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD---VKALRA 573
T E V+K++ +G + HP AY R+ WNILDFI+V LV+ S +G D +K+LR
Sbjct: 1200 TFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFS--GSKGKDISTIKSLRV 1257
Query: 574 FRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTC 753
RVLRPL+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF GK C
Sbjct: 1258 LRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF-YC 1316
Query: 754 IDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDN 933
D + + ++D D E + QP +W+ ++DN
Sbjct: 1317 TDES--KELERDCRGQYLDYEKEEVEAQPR--------QWKKYD-----------FHYDN 1355
Query: 934 FGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWP---------WIYFVTLVILGSFFVLNL 1086
A+LT+F + EGW V+ DA E I++V ++ FF +N+
Sbjct: 1356 VLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNI 1415
Query: 1087 VLGVLSGEFSKEREKARARGLFQK 1158
+ ++ F ++ +K + +K
Sbjct: 1416 FVALIIITFQEQGDKVMSECSLEK 1439
Score = 119 bits (299), Expect = 6e-25
Identities = 80/293 (27%), Positives = 141/293 (47%), Gaps = 8/293 (2%)
Frame = +1
Query: 3268 FALKAKPHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFL 3447
F K K R +I R V +++F + + ++ +NT+ +A HY + L
Sbjct: 465 FRRKEKMFRFFIRR---------MVKAQSFYWTVLCVVALNTLCVAMVHYNQPQRLTTAL 515
Query: 3448 DVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLI 3627
+F G+F E LK+ L P++Y +N FD V+VGS ++ + + PG +
Sbjct: 516 YFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSIFEVVWAAVKPGTS--F 573
Query: 3628 SINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF- 3804
I+ R R++R+ K+ +R L+ + + S +++ + L+ L ++A++GMQ F
Sbjct: 574 GISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFG 633
Query: 3805 GKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYH- 3981
G+ D T NF +FPAAIL +F+ TGE W +M YH
Sbjct: 634 GQFNFKDETP---TTNFDTFPAAILTVFQILTGEDWNAVM-----------------YHG 673
Query: 3982 ---KGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF---DYLTRD 4122
+GG++ F+ YFI + ++ ++N+F+A+ +DN LT+D
Sbjct: 674 IESQGGVSRGM----FSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 722
Score = 98.6 bits (244), Expect = 2e-18
Identities = 73/295 (24%), Positives = 134/295 (44%), Gaps = 12/295 (4%)
Frame = +1
Query: 265 PFEFLILFMICANCIALAIYQPYPAQDSDYKNTL-LETIEYVFIVVFTIECVLKIVAMGF 441
PFE+ I+ MI N + L + D+ Y+ L L+ + VF +F++ECVLKI+A G
Sbjct: 1477 PFEYFIMAMIALNTVVLMM----KFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGV 1532
Query: 442 MFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSL 621
+ Y R+AWN+ DF+ V+ + ++++++ ++ LR FR R ++L+ ++
Sbjct: 1533 L----NYFRDAWNVFDFVTVLGSITDILVTEIANNFINLSFLRLFRAARLIKLLRQGYTI 1588
Query: 622 QVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPC 801
+++L +++ L ++ LL+ + IYAIIG+++F G +A D T
Sbjct: 1589 RILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------GNIALDDDTSI 1635
Query: 802 GTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEG 981
N NF F A++ +F+ + E
Sbjct: 1636 ------------------------------------NRHNNFRTFLQALMLLFRSATGEA 1659
Query: 982 WTDVM-----------YWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
W ++M + G ++ + YFV+ + L SF +LNL + V+ F
Sbjct: 1660 WHEIMLSCLSSRACDEHSNASECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1714
Score = 85.9 bits (211), Expect = 1e-14
Identities = 71/265 (26%), Positives = 117/265 (43%), Gaps = 16/265 (6%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLF+ S N R + + F +L I+ + +LA E L M L+
Sbjct: 74 SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 133
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV-----AVSLTSFVLRTDAM 2667
+ +F +F E +K++ G V HKGS+ RN +N++D +VV A + T F LRT
Sbjct: 134 EPYFIGIFCFEAGIKILALGFVLHKGSYLRNGWNVMDFVVVLTGILATAGTDFDLRT--- 190
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
++ L+ V++ ++ A+ + I L+ F MFAIIG++ +
Sbjct: 191 -----LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY 245
Query: 2848 KGTFFLC-----NDLSKMTEAECRGEY-IHYEDGDPTKPVSKKRVWSNNDF---NFDNVG 3000
G F D + + C E +GD + W+ +F NFDN+
Sbjct: 246 MGKFHKACFPNSTDPDPVGDFPCGKEAPARLCEGD----TECREYWAGPNFGITNFDNIL 301
Query: 3001 DAMISLFVVSTFEGWPQLLYVAIDS 3075
A++++F T EGW +LY D+
Sbjct: 302 FAILTVFQCITMEGWTDILYNTNDA 326
Score = 85.1 bits (209), Expect = 2e-14
Identities = 77/292 (26%), Positives = 123/292 (41%), Gaps = 42/292 (14%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVA----L 3513
FEY+I I+ N + LA + H P + LD F G+F FEA +KI+A L
Sbjct: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKILALGFVL 156
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WNV D +VV+ G L GT+ + R RV+R +KL+S
Sbjct: 157 HKGSYLRNGWNVMDFVVVL-------TGILATAGTD-FDLRTLRAVRVLRPLKLVSGIPS 208
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQF----FGKVALDDSTS--------- 3834
++ +L + MK+ L + LL+ ++A+IG++F F K +ST
Sbjct: 209 LQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDPDPVGDFPC 268
Query: 3835 ----------------------IHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDRED 3948
NF + AIL +F+ T E W DI+ + +D
Sbjct: 269 GKEAPARLCEGDTECREYWAGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTND--- 325
Query: 3949 VRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
GN + + YFI ++ SF ++NL + V+ F
Sbjct: 326 ------------------AAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 359
Score = 72.4 bits (176), Expect = 1e-10
Identities = 55/204 (26%), Positives = 88/204 (42%), Gaps = 7/204 (3%)
Frame = +1
Query: 1525 NLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVL 1704
N+ F +FSME +LK+ + G Y +N FD V+ SI + +LV + +S L
Sbjct: 1512 NIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITD-ILVTEIANNFINLSFL 1570
Query: 1705 RSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNF 1884
R R R+ K+ + GMQVFG
Sbjct: 1571 RLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALD 1630
Query: 1885 NPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIES-----FGGVGTLGVIVCIYY 2049
+ NF TF+QAL+ +F+ TGE W+ +M + S G +Y
Sbjct: 1631 DDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSSRACDEHSNASECGSDFAYFY 1690
Query: 2050 IV--LFICGNYILLNVFLAIAVDN 2115
V +F+C ++++LN+F+A+ +DN
Sbjct: 1691 FVSFIFLC-SFLMLNLFVAVIMDN 1713
Score = 56.6 bits (135), Expect = 7e-06
Identities = 56/264 (21%), Positives = 105/264 (39%), Gaps = 3/264 (1%)
Frame = +1
Query: 2293 AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN 2472
A +++K SS + FR F +V F VL C++ + + A
Sbjct: 450 ARASLKSGKTESSSYFRRKEKMFRFFIRRMVKAQSFYWTVL-CVVALNTLCVAMVHYNQP 508
Query: 2473 STRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL 2652
L + ++ F +F E++LK+ G S+ R++FN D V+ S+ V
Sbjct: 509 QRLTTALYFAEFVFLGLFLTEMSLKMYGLG----PRSYFRSSFNCFDFGVIVGSIFEVVW 564
Query: 2653 RTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
K L+++V ++ ++K+I +++ + F+ +F
Sbjct: 565 AAVKPGTSFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVF 624
Query: 2824 AIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGD 3003
A++G+QLF G F +++D PT NFD
Sbjct: 625 ALLGMQLFGGQF-------------------NFKDETPTT-------------NFDTFPA 652
Query: 3004 AMISLFVVSTFEGWPQLLYVAIDS 3075
A++++F + T E W ++Y I+S
Sbjct: 653 AILTVFQILTGEDWNAVMYHGIES 676
Score = 52.0 bits (123), Expect = 2e-04
Identities = 52/230 (22%), Positives = 88/230 (37%), Gaps = 38/230 (16%)
Frame = +1
Query: 1534 FVILFSMEMLLKMYSLGFTTYTTSQF----NRFDCFVVISSILEFVLVYFDLMKPLGVSV 1701
F +F+ EM++KM LG + + F N D VV +++ F F K +S
Sbjct: 1195 FTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFA---FSGSKGKDIST 1251
Query: 1702 LRSARLLRIF---KVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGG 1872
++S R+LR+ K K +Q+F G
Sbjct: 1252 IKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKG 1311
Query: 1873 KFNFNPQQPK---------------------PRA------NFDTFVQALLTVFQILTGED 1971
KF + + K PR ++D + ALLT+F + TGE
Sbjct: 1312 KFFYCTDESKELERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEG 1371
Query: 1972 WNTVMYHGI----ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
W V+ H + E G + + I+Y+V F+ + +N+F+A+ +
Sbjct: 1372 WPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALII 1421
>gi|14578563|gb|AAK33009.1| calcium channel isoform alpha1E7 [Rattus
norvegicus]
Length = 2295
Score = 664 bits (1712), Expect = 0.0
Identities = 354/774 (45%), Positives = 483/774 (61%), Gaps = 13/774 (1%)
Frame = +1
Query: 2302 TVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR 2481
T K + SS+FI S TN R C+ +VN YF +L I SS LAAEDP+ NS R
Sbjct: 1105 TGKAMVPHSSMFIFSTTNPIRKACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSER 1164
Query: 2482 NMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTD 2661
N +L YFDY FT VFT E+ +K+I GL+ GS+ R+ +N+LD +VV +L +F L
Sbjct: 1165 NKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANA 1224
Query: 2662 A-------MSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFM 2820
+ I R LK V CV+ ++K + NI++V + F+
Sbjct: 1225 LGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFI 1284
Query: 2821 FAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVG 3000
FA+I VQLFKG FF C D SK TE EC G Y+ +E K K R W ++F++DN+
Sbjct: 1285 FAVIAVQLFKGKFFYCTDSSKDTEKECIGNYVDHEKN---KMEVKGREWKRHEFHYDNII 1341
Query: 3001 DAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXX 3180
A+++LF VST EGWPQ+L ++D EED+GP ++R +++
Sbjct: 1342 WALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFV 1401
Query: 3181 GFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRA 3354
+I+TFQ +G++ E C L+KN+R CI+FA+ AKP RY+P+NR QYRVW FV S +
Sbjct: 1402 ALIIITFQEQGDKMMEECSLEKNERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPS 1461
Query: 3355 FEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYIS 3534
FEY I +I +NTV L K+Y + +E L N+ FT VF+ E VLK++A NY
Sbjct: 1462 FEYTIMAMIALNTVVLMMKYYSAPWTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFR 1521
Query: 3535 DRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWT 3714
D WN+FD + V+GS +I T+ +++F LFR RL+KLL +G IR LLWT
Sbjct: 1522 DTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLELFRAARLIKLLRQGYTIRILLWT 1581
Query: 3715 FMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRS 3894
F++SF+ALPYV LLI +LFFIYA+IGMQ FG + LD+ + I+R+NNF SF ++++LFRS
Sbjct: 1582 FVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRS 1641
Query: 3895 ATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNES-RCGNNFAYPYFISFFMLCSFLVI 4071
ATGEAWQ+IMLSC + C+P D G NES RCG + AY YF+SF CSFL++
Sbjct: 1642 ATGEAWQEIMLSCLGEKG--CEP--DTTAPSGQNESERCGTDLAYVYFVSFIFFCSFLML 1697
Query: 4072 NLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPL 4251
NLFVAVIMDNF+YLTRD SILGPHHL+EFVR+W+EYD A GRI + ++ +L +SPPL
Sbjct: 1698 NLFVAVIMDNFEYLTRDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPL 1757
Query: 4252 GFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKI-YTEGNID--EANEQL 4422
G GK CP ++A KRLV MNMP+ D TV F +TL AL+RT L I +G D + + +L
Sbjct: 1758 GLGKRCPSKVAYKRLVLMNMPVAEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSEL 1817
Query: 4423 RSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEME 4584
+ IW + +LD +V P K D+TVGK YA +I DY+++ K +K+ +
Sbjct: 1818 QKETLAIWPHLSQKMLDLLV-PMPKASDLTVGKIYAAMMIMDYYKQSKVKKQRQ 1870
Score = 514 bits (1323), Expect = e-143
Identities = 285/667 (42%), Positives = 374/667 (55%), Gaps = 27/667 (4%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N +RK +++W PFE++IL I ANCI LA+ Q P D + LE E FI +
Sbjct: 75 DNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGI 134
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KIVA+GF+FH +YLRN WN++DFI+V+ G+++T + + D++ LRA R
Sbjct: 135 FCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTH-VDLRTLRAVR 193
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQ+VL +I++AM+PLL I LL+ F IL++AIIGLE + GKLH C
Sbjct: 194 VLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFM 253
Query: 760 PATGQLAQKDPT-PCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNF 936
+G L DP PCG + ++C+ W GPN+GIT FDN
Sbjct: 254 NNSGILEGFDPPHPCGVQGCPAGYECKD------------------WIGPNDGITQFDNI 295
Query: 937 GLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFS 1116
A+LTVFQC+++EGWT V+Y NDA+G W W+YF+ L+I+GSFFVLNLVLGVLSGEF+
Sbjct: 296 LFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFA 355
Query: 1117 KEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNED---------------- 1248
KERE+ R F K R +QQ+E +L GY WI +AE++ E+
Sbjct: 356 KERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNSGTSALEVLRRATI 415
Query: 1249 ----------EQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXX 1398
+ DE + + +RL +++
Sbjct: 416 KRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSTKVDGASYFRHKERLLRIS------I 469
Query: 1399 XXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYS 1578
+VKSQ FYW H+ Q +WL H A F+ LF +EM LKMY
Sbjct: 470 RHMVKSQVFYWIVLSVVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYG 529
Query: 1579 LGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXX 1758
+G Y S FN FD V + SI E V F G+SVLR+ RLLRIFK+TKYW
Sbjct: 530 MGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASL 589
Query: 1759 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQAL 1938
GMQ+FGG+FNFN P ANFDTF A+
Sbjct: 590 RNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFN--DGTPSANFDTFPAAI 647
Query: 1939 LTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNL 2118
+TVFQILTGEDWN V+Y+GI S GGV + G+ IY+IVL + GNY LLNVFLAIAVDNL
Sbjct: 648 MTVFQILTGEDWNEVLYNGIRSQGGVSS-GMWSAIYFIVLTLFGNYTLLNVFLAIAVDNL 706
Query: 2119 ADADSLT 2139
A+A LT
Sbjct: 707 ANAQELT 713
Score = 131 bits (330), Expect = 2e-28
Identities = 102/378 (26%), Positives = 172/378 (44%), Gaps = 14/378 (3%)
Frame = +1
Query: 139 KRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIALA 318
++ Q+K R+T NPIRK C IV + FE IL +I A+ IALA
Sbjct: 1094 EKKKQKKEKRETGKAMVPHSSMFIFSTTNPIRKACHYIVNLRYFEMCILLVIAASSIALA 1153
Query: 319 IYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFII 498
P +N +L +YVF VFT E V+K++ G + +Y R+ WNILDF++
Sbjct: 1154 AEDPVLTNSE--RNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVV 1211
Query: 499 VVIGLVSTILSKM--SIQGFD---VKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPL 663
VV LV+ L+ + +G D +K+LR RVLRPL+ + +P L+ V + ++ ++ +
Sbjct: 1212 VVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNV 1271
Query: 664 LHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPS 843
+I ++ + I+A+I ++LF GK C D + DTE
Sbjct: 1272 FNILIVYKLFMFIFAVIAVQLFKGKFF-YCTDSS-------------KDTEKECIGNYVD 1317
Query: 844 DSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAV-- 1017
M V+ W ++DN A+LT+F + EGW V+ D
Sbjct: 1318 HEKNKMEVK-----GREW---KRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEE 1369
Query: 1018 -------GREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQQ 1176
R I++V ++ FF +N+ + ++ F ++ + K E+
Sbjct: 1370 DRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGD---------KMMEECS 1420
Query: 1177 LEEDLKGYLDWITQAEDI 1230
LE++ + +D+ A+ +
Sbjct: 1421 LEKNERACIDFAISAKPL 1438
Score = 115 bits (287), Expect = 2e-23
Identities = 71/273 (26%), Positives = 137/273 (50%), Gaps = 4/273 (1%)
Frame = +1
Query: 3316 LQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAV 3495
L+ + V S+ F +++ ++ +NT +A H+ + L +F G+F E
Sbjct: 465 LRISIRHMVKSQVFYWIVLSVVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMS 524
Query: 3496 LKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKL 3675
LK+ + P+ Y +N FD V VGS ++ + PG + I+ R R++R+ K+
Sbjct: 525 LKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTS--FGISVLRALRLLRIFKI 582
Query: 3676 LSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNN 3852
+R L+ + M S +++ + L+ L ++A++GMQ F G+ +D T + N
Sbjct: 583 TKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTP---SAN 639
Query: 3853 FHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPY 4032
F +FPAAI+ +F+ TGE W +++ + +R +GG++ ++ Y
Sbjct: 640 FDTFPAAIMTVFQILTGEDWNEVLYN-----GIR--------SQGGVSSGM----WSAIY 682
Query: 4033 FISFFMLCSFLVINLFVAVIMDNF---DYLTRD 4122
FI + ++ ++N+F+A+ +DN LT+D
Sbjct: 683 FIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 715
Score = 86.7 bits (213), Expect = 6e-15
Identities = 74/303 (24%), Positives = 132/303 (43%), Gaps = 21/303 (6%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+ I+ MI N + L + Y + Y+ L+ + F +VF++ECVLK++A GF+
Sbjct: 1462 FEYTIMAMIALNTVVLMM--KYYSAPWTYE-LALKYLNIAFTMVFSLECVLKVIAFGFL- 1517
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMSI---QGFDVKALRAFRVLRPLRLVSGVPS 618
Y R+ WNI DFI V+ + IL+ + GF++ L FR R ++L+ +
Sbjct: 1518 ---NYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLELFRAARLIKLLRQGYT 1574
Query: 619 LQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTP 798
++++L +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1575 IRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF----------------------- 1611
Query: 799 CGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLE 978
N+ + E N +N +F FG ML +F+ + E
Sbjct: 1612 ------------------GNIKLDEESHINR-----HNNFRSF--FGSLML-LFRSATGE 1645
Query: 979 GWTDVMYWV------------------NDAVGREWPWIYFVTLVILGSFFVLNLVLGVLS 1104
W ++M ++ G + ++YFV+ + SF +LNL + V+
Sbjct: 1646 AWQEIMLSCLGEKGCEPDTTAPSGQNESERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIM 1705
Query: 1105 GEF 1113
F
Sbjct: 1706 DNF 1708
Score = 84.7 bits (208), Expect = 2e-14
Identities = 79/346 (22%), Positives = 152/346 (43%), Gaps = 9/346 (2%)
Frame = +1
Query: 232 RKLCISI---VEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
R L ISI V+ + F +++L ++ N +AI Q + LL E++F+ +F
Sbjct: 463 RLLRISIRHMVKSQVFYWIVLSVVALNTACVAIVHHNQPQ---WLTHLLYYAEFLFLGLF 519
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKALRAF 576
+E LK+ MG P Y +++N DF + V G + ++ + G F + LRA
Sbjct: 520 LLEMSLKMYGMG----PRLYFHSSFNCFDFGVTV-GSIFEVVWAIFRPGTSFGISVLRAL 574
Query: 577 RVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI 756
R+LR ++ SL+ ++ +++ +M ++ + L+ I+++A++G++LF G+ +
Sbjct: 575 RLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFN-- 632
Query: 757 DPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNF 936
D TP NFD F
Sbjct: 633 ----------DGTPSA---------------------------------------NFDTF 643
Query: 937 GLAMLTVFQCVSLEGWTDVMYWVNDAVG----REWPWIYFVTLVILGSFFVLNLVLGVLS 1104
A++TVFQ ++ E W +V+Y + G W IYF+ L + G++ +LN+ L +
Sbjct: 644 PAAIMTVFQILTGEDWNEVLYNGIRSQGGVSSGMWSAIYFIVLTLFGNYTLLNVFLAIAV 703
Query: 1105 GEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVN 1242
+ Q+ + +Q EE+ + +A+++ P++
Sbjct: 704 DNLANA----------QELTKDEQEEEEAFNQKHALQKAKEVSPMS 739
Score = 79.0 bits (193), Expect = 1e-12
Identities = 68/267 (25%), Positives = 114/267 (42%), Gaps = 18/267 (6%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLFI N R + +++ F +L I+ + +LA E L + M L
Sbjct: 68 SLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT 127
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV-----AVSLTSFVLRTDAM 2667
+ +F +F E +K++ G +FHKGS+ RN +N++D +VV A + T F D
Sbjct: 128 EPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLR 187
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
+ ++ L+ V++ ++ A+ + I L+ F MFAIIG++ +
Sbjct: 188 T----LRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY 243
Query: 2848 KGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVS----------KKRVWSNNDF-NFDN 2994
G K+ A E DP P K + N+ FDN
Sbjct: 244 SG---------KLHRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDN 294
Query: 2995 VGDAMISLFVVSTFEGWPQLLYVAIDS 3075
+ A++++F T EGW +LY D+
Sbjct: 295 ILFAVLTVFQCITMEGWTTVLYNTNDA 321
Score = 78.6 bits (192), Expect = 2e-12
Identities = 117/586 (19%), Positives = 204/586 (33%), Gaps = 71/586 (12%)
Frame = +1
Query: 1531 FFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVS 1698
+F+ +F E +K+ +LGF +Y + +N D VV+S IL +F+ L
Sbjct: 130 YFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDL--R 187
Query: 1699 VLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF 1878
LR+ R+LR K+ G++ + GK
Sbjct: 188 TLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKL 247
Query: 1879 N-------------FNPQQP-------------------KPRANFDTFVQALLTVFQILT 1962
+ F+P P FD + A+LTVFQ +T
Sbjct: 248 HRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCIT 307
Query: 1963 GEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLA------- 2121
E W TV+Y+ ++ G +Y+I L I G++ +LN+ L + A
Sbjct: 308 MEGWTTVLYNTNDALGATWNW-----LYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVE 362
Query: 2122 ------------DADSLTNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSA 2265
+ N T A
Sbjct: 363 NRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNSGTSALEVLRRATIKRSRTEA 422
Query: 2266 RPRRMSE---VPAASTVKPIPKAS--------SLFILSHTNSFRVFCNMVVNHSYFTNAV 2412
R S+ V +S P+ +AS + + R+ +V F V
Sbjct: 423 MTRDSSDEHCVDISSVGTPLARASIKSTKVDGASYFRHKERLLRISIRHMVKSQVFYWIV 482
Query: 2413 LFCILVSSAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFG--LVFHKGSF 2586
L + +++A +A Q ++ L Y ++ F +F +E++LK+ G L FH
Sbjct: 483 LSVVALNTACVAIVHHNQPQWLTHL-LYYAEFLFLGLFLLEMSLKMYGMGPRLYFH---- 537
Query: 2587 CRNAFNLLDILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQC 2757
++FN D V S+ V K L+++V
Sbjct: 538 --SSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVS 595
Query: 2758 VIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDP 2937
++ ++K+I +++ + F+ +FA++G+QLF G F ++ DG P
Sbjct: 596 LMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF-------------------NFNDGTP 636
Query: 2938 TKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
+ NFD A++++F + T E W ++LY I S
Sbjct: 637 SA-------------NFDTFPAAIMTVFQILTGEDWNEVLYNGIRS 669
Score = 78.2 bits (191), Expect = 2e-12
Identities = 104/484 (21%), Positives = 184/484 (37%), Gaps = 46/484 (9%)
Frame = +1
Query: 1534 FVILFSMEMLLKMYSLGFTTYTTSQF----NRFDCFVVISSILEFVLVY-FDLMKPLGVS 1698
F +F+ EM++KM G S F N D VV+ +++ F L K +
Sbjct: 1175 FTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIK 1234
Query: 1699 VLRSARLLRIF---KVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFG 1869
++S R+LR+ K K +Q+F
Sbjct: 1235 TIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFK 1294
Query: 1870 GKFNF---------------------NPQQPKPRA------NFDTFVQALLTVFQILTGE 1968
GKF + N + K R ++D + ALLT+F + TGE
Sbjct: 1295 GKFFYCTDSSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGE 1354
Query: 1969 DWNTVMYHGI----ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLAD-ADS 2133
W V+ H + E G + + + I+Y+V F+ + +N+F+A+ + + D
Sbjct: 1355 GWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDK 1414
Query: 2134 LTNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSARPRRMSEVPAASTVKP 2313
+ S + + A + KP
Sbjct: 1415 MMEE-------------------------------------CSLEKNERACIDFAISAKP 1437
Query: 2314 IPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMIL 2493
+ + HT +RV+ + VV+ S F ++ I +++ +L + A T + L
Sbjct: 1438 LTRYMPQ--NRHTFQYRVW-HFVVSPS-FEYTIMAMIALNTVVLMMK-YYSAPWTYELAL 1492
Query: 2494 NYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSX 2673
Y + FT VF++E LKVI FG + ++ R+ +N+ D + V S+T +L TD+
Sbjct: 1493 KYLNIAFTMVFSLECVLKVIAFGFL----NYFRDTWNIFDFITVIGSITEIIL-TDSKLV 1547
Query: 2674 XXXXXXXXXXXXXXAINRAKGLKH------VVQCVIVAVKTIGNIMLVTFMLQFMFAIIG 2835
A K L+ ++ + + K + + L+ ML F++AIIG
Sbjct: 1548 NTSGFNMSFLELFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIG 1607
Query: 2836 VQLF 2847
+Q+F
Sbjct: 1608 MQVF 1611
Score = 77.8 bits (190), Expect = 3e-12
Identities = 75/303 (24%), Positives = 124/303 (40%), Gaps = 53/303 (17%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACKHY-------PSSRGFEDFLDVFNLIFTGVFAFEAVLKIVAL 3513
FEY+I I+ N + LA + + P SR E F G+F FEA +KIVAL
Sbjct: 91 FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT----EPYFIGIFCFEAGIKIVAL 146
Query: 3514 ----NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNL---ISINFFRLFRVMRLVK 3672
+ +Y+ + WNV D +VV+ G L GT+ + + R RV+R +K
Sbjct: 147 GFIFHKGSYLRNGWNVMDFIVVLS-------GILATAGTHFNTHVDLRTLRAVRVLRPLK 199
Query: 3673 LLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHR--- 3843
L+S ++ +L + MK+ L + LL+ ++A+IG++F+ S +HR
Sbjct: 200 LVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY-------SGKLHRACF 252
Query: 3844 -NNN-----------------------------------FHSFPAAILVLFRSATGEAWQ 3915
NN+ F + A+L +F+ T E W
Sbjct: 253 MNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWT 312
Query: 3916 DIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIM 4095
++ + +D G + + YFI ++ SF V+NL + V+
Sbjct: 313 TVLYNTND---------------------ALGATWNWLYFIPLIIIGSFFVLNLVLGVLS 351
Query: 4096 DNF 4104
F
Sbjct: 352 GEF 354
Score = 65.5 bits (158), Expect = 1e-08
Identities = 52/214 (24%), Positives = 85/214 (39%), Gaps = 17/214 (7%)
Frame = +1
Query: 1525 NLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLG--VS 1698
N+ F ++FS+E +LK+ + GF Y +N FD VI SI E +L L+ G +S
Sbjct: 1496 NIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMS 1555
Query: 1699 VLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF 1878
L R R+ K+ + GMQVFG
Sbjct: 1556 FLELFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIK 1615
Query: 1879 NFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFG---------------G 2013
NF +F +L+ +F+ TGE W +M + G
Sbjct: 1616 LDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQNESER 1675
Query: 2014 VGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDN 2115
GT + +Y++ ++++LN+F+A+ +DN
Sbjct: 1676 CGT--DLAYVYFVSFIFFCSFLMLNLFVAVIMDN 1707
>gi|5921456|sp|P56698|CCAB_DISOM Probable voltage-dependent N-type
calcium channel alpha-1B subunit (Voltage-gated calcium
channel alpha subunit Cav2.2) (DOE-4)
gi|477714|pir||B47447 calcium channel protein alpha-1 chain (variant
doe-4) - electric ray (Discopyge ommata)
Length = 2326
Score = 663 bits (1711), Expect = 0.0
Identities = 342/764 (44%), Positives = 489/764 (63%), Gaps = 8/764 (1%)
Frame = +1
Query: 2308 KPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNM 2487
+ IP +S+F+ S TN R C+ +VN YF +L I +SS LAAEDP+Q ++ RN
Sbjct: 1119 RQIPPFNSMFLFSTTNPVRRACHYIVNLRYFEMCILLVITMSSIALAAEDPVQGDAPRNN 1178
Query: 2488 ILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL---RT 2658
+L Y DY FT VFT E+ +K+I GL+ H GS+ R+ +N+LD +VV+ +L +F R
Sbjct: 1179 VLKYLDYVFTGVFTFEMVIKMINLGLILHPGSYFRDLWNILDFIVVSGALVAFAFTGSRG 1238
Query: 2659 DAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGV 2838
++ I R LK V CV+ ++K + NI++V + F+FA+I V
Sbjct: 1239 KDLNTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAV 1298
Query: 2839 QLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISL 3018
QLFKG FF C D SK E +CRG+Y+ Y++ + ++ R W DF++DNV A+++L
Sbjct: 1299 QLFKGKFFYCTDESKDLEKDCRGQYLVYDNDEIE---AEPREWKKCDFHYDNVLWALLTL 1355
Query: 3019 FVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIVT 3198
F VST EGWP +L +ID+ EED+GP + R +++ +I+T
Sbjct: 1356 FTVSTGEGWPTVLKNSIDATEEDQGPSPSYRMEMSIFYVVYFVVFPFFFVNIFVALIIIT 1415
Query: 3199 FQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRAFEYVIF 3372
FQ +G++ +C L+KN+R CI+FA+ AKP RY+P+N+ QY++W FV S FEY+I
Sbjct: 1416 FQEQGDKVMSDCSLEKNERACIDFAISAKPLTRYMPQNKQTFQYKMWKFVVSPPFEYLIM 1475
Query: 3373 LIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVF 3552
+I +NT+ L K Y + ++ L N++FT +F+ E VLK++ NY D WNVF
Sbjct: 1476 ALIALNTIVLMMKFYNAPDPYDRMLQYLNILFTFLFSMECVLKLIGFGVLNYFRDAWNVF 1535
Query: 3553 DLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQ 3732
D + V+GS DI +L + I+++F RLFR RL+KLL +G IR LLWTF++SF+
Sbjct: 1536 DFVTVLGSITDILVTEL---ADSFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFK 1592
Query: 3733 ALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAW 3912
ALPYV LLI +LFFIYA+IGMQ FG + LDD +I+R+NNF +F A+++L RSATGE W
Sbjct: 1593 ALPYVCLLIAMLFFIYAIIGMQVFGNIELDDDGAINRHNNFRTFLQAVMLLLRSATGEGW 1652
Query: 3913 QDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVI 4092
Q+IML+C ++ CD S G++ CG+NFAY YF+SF SFL++NLFVAVI
Sbjct: 1653 QEIMLACLNQSP--CDARS------GIDGDECGSNFAYFYFVSFIFFSSFLMLNLFVAVI 1704
Query: 4093 MDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCP 4272
MDNF+YLTRD SILGPHHL+EF+R+W+EYDP A+GRI + D+ +LR + PPLG GK CP
Sbjct: 1705 MDNFEYLTRDSSILGPHHLDEFIRVWAEYDPGARGRITYNDMYEMLRHMCPPLGLGKKCP 1764
Query: 4273 HRLACKRLVSMNMPLNSDGTVCFNATLFALVRT--NLKIYTEGNI-DEANEQLRSAIKRI 4443
R+A KRLV MNMP+ DG+V F +TL AL+RT ++KI G + + +LR I +
Sbjct: 1765 ARVAYKRLVRMNMPIAEDGSVHFTSTLMALIRTALDVKISPGGAYQQQCDAELRKEITAV 1824
Query: 4444 WKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRK 4575
W + LD +VPP + ++TVGK YA +I DY+++ K +K
Sbjct: 1825 WPNLSQKFLDILVPPQ-RASELTVGKVYAALMIYDYYKQNKSKK 1867
Score = 500 bits (1288), Expect = e-139
Identities = 287/659 (43%), Positives = 369/659 (55%), Gaps = 19/659 (2%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N IRK I EW PFE++IL I ANCI LA+ Q P D + L+ E FI +
Sbjct: 74 DNIIRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGI 133
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KI+A+GF FH +YLRN WN++DF++V+ G+++TI + FD++ LRA R
Sbjct: 134 FCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILTTIGTD-----FDLRTLRAVR 188
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQVVL +I++AM+PLL I LL+ F IL++AIIGLE + GK H TC
Sbjct: 189 VLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKTCFS 248
Query: 760 PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFG 939
T + ++ PCGT PS N V C W GPN GITNFDN
Sbjct: 249 EETNEPVEE--FPCGTK--------YPSRLCPNGTV---CKGY--WNGPNFGITNFDNIL 293
Query: 940 LAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSK 1119
A+LTVFQC+++EGWTD++Y NDA+G W W+YF+ L+++GSFF+LNLVLGVLSGEF+K
Sbjct: 294 FAVLTVFQCITMEGWTDMLYTANDALGNTWNWLYFIPLIVIGSFFMLNLVLGVLSGEFAK 353
Query: 1120 EREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVAQTXXXXXXX 1299
ERE+ R F K R +QQ+E++ YL WI AE++ ED+ ++ A
Sbjct: 354 ERERVENRRAFLKLRRQQQVEQEFNRYLRWIHIAEEVMLAEEDKNAEDKCALDVLKRATT 413
Query: 1300 ----------------XXXXXXXXXXXPSKWAARMKR---LEKLNXXXXXXXXXLVKSQT 1422
PS + + +R + +VKSQ+
Sbjct: 414 KKSKNDLINAEEGEDHFTDISSVGFNRPSLKSVKNERSSYFRRKEKRFRFFIRRMVKSQS 473
Query: 1423 FYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTT 1602
FYW HY Q L A F+ LF EM LKMY LG Y
Sbjct: 474 FYWIVLCLVGLNTLCVAIVHYDQPPLLTDALYFAEFVFLGLFLTEMSLKMYGLGPRNYFH 533
Query: 1603 SQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXX 1782
S FN FD V++ SI E V G+SVLR+ RLLRIFKVTKYW
Sbjct: 534 SSFNCFDFGVIVGSIFEVVWTAVKPDTSFGISVLRALRLLRIFKVTKYWNSLRNLVVSLL 593
Query: 1783 XXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILT 1962
GMQ+FGG+FNF + P NFDTF A+LTVFQILT
Sbjct: 594 NSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF--EDGTPPTNFDTFPAAILTVFQILT 651
Query: 1963 GEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLT 2139
GEDWN VMY+GIE+ GGV G+ +Y+I+L + GNY LLNVFLAIAVDNLA+A LT
Sbjct: 652 GEDWNEVMYYGIEAHGGV-KKGMFSSVYFIILTLFGNYTLLNVFLAIAVDNLANAQELT 709
Score = 166 bits (420), Expect = 6e-39
Identities = 151/649 (23%), Positives = 264/649 (40%), Gaps = 18/649 (2%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+R+ C IV + FE IL +I + IALA P Q +N +L+ ++YVF VF
Sbjct: 1134 NPVRRACHYIVNLRYFEMCILLVITMSSIALAAEDP--VQGDAPRNNVLKYLDYVFTGVF 1191
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD-VKALRAFR 579
T E V+K++ +G + HP +Y R+ WNILDFI+V LV+ + + + +K+LR R
Sbjct: 1192 TFEMVIKMINLGLILHPGSYFRDLWNILDFIVVSGALVAFAFTGSRGKDLNTIKSLRVLR 1251
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF GK C D
Sbjct: 1252 VLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFY-CTD 1310
Query: 760 PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFG 939
+ +KD + + +P + W+ ++DN
Sbjct: 1311 ESKD--LEKDCRGQYLVYDNDEIEAEPRE--------WKKCD-----------FHYDNVL 1349
Query: 940 LAMLTVFQCVSLEGWTDVMYWVNDAVGREWP---------WIYFVTLVILGSFFVLNLVL 1092
A+LT+F + EGW V+ DA + I++V ++ FF +N+ +
Sbjct: 1350 WALLTLFTVSTGEGWPTVLKNSIDATEEDQGPSPSYRMEMSIFYVVYFVVFPFFFVNIFV 1409
Query: 1093 GVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVA 1272
++ F ++ + K LE++ + +D+ A+ P+ +++
Sbjct: 1410 ALIIITFQEQGD---------KVMSDCSLEKNERACIDFAISAK---PLTRYMPQNKQTF 1457
Query: 1273 QTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXX 1452
Q W V S F +
Sbjct: 1458 QY-------------------KMWK-------------------FVVSPPFEYLIMALIA 1479
Query: 1453 XXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFV 1632
+ Y + D N+ F LFSME +LK+ G Y +N FD
Sbjct: 1480 LNTIVLMMKFYNAPDPYDRMLQYLNILFTFLFSMECVLKLIGFGVLNYFRDAWNVFDFVT 1539
Query: 1633 VISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXX 1812
V+ SI + +LV + +S LR R R+ K+ +
Sbjct: 1540 VLGSITD-ILVTELADSFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVC 1598
Query: 1813 XXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYH 1992
GMQVFG + NF TF+QA++ + + TGE W +M
Sbjct: 1599 LLIAMLFFIYAIIGMQVFGNIELDDDGAINRHNNFRTFLQAVMLLLRSATGEGWQEIMLA 1658
Query: 1993 GIESFGGVGTLGV--------IVCIYYIVLFICGNYILLNVFLAIAVDN 2115
+ G+ Y++ ++++LN+F+A+ +DN
Sbjct: 1659 CLNQSPCDARSGIDGDECGSNFAYFYFVSFIFFSSFLMLNLFVAVIMDN 1707
Score = 122 bits (307), Expect = 8e-26
Identities = 83/297 (27%), Positives = 145/297 (47%), Gaps = 4/297 (1%)
Frame = +1
Query: 3244 KNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPS 3423
KN+R F K K R +I R V S++F +++ ++ +NT+ +A HY
Sbjct: 447 KNERSSY-FRRKEKRFRFFIRR---------MVKSQSFYWIVLCLVGLNTLCVAIVHYDQ 496
Query: 3424 SRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKL 3603
D L +F G+F E LK+ L P+NY +N FD V+VGS ++ + +
Sbjct: 497 PPLLTDALYFAEFVFLGLFLTEMSLKMYGLGPRNYFHSSFNCFDFGVIVGSIFEVVWTAV 556
Query: 3604 NPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYA 3783
P + I+ R R++R+ K+ +R L+ + + S +++ + L+ L ++A
Sbjct: 557 KPDTS--FGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFA 614
Query: 3784 VIGMQFF-GKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCD 3960
++GMQ F G+ +D T NF +FPAAIL +F+ TGE W ++M +
Sbjct: 615 LLGMQLFGGQFNFEDGTP---PTNFDTFPAAILTVFQILTGEDWNEVMYYGIEAH----- 666
Query: 3961 PMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF---DYLTRD 4122
GG+ + F+ YFI + ++ ++N+F+A+ +DN LT+D
Sbjct: 667 --------GGVKKGM----FSSVYFIILTLFGNYTLLNVFLAIAVDNLANAQELTKD 711
Score = 95.9 bits (237), Expect = 1e-17
Identities = 74/314 (23%), Positives = 136/314 (42%), Gaps = 18/314 (5%)
Frame = +1
Query: 226 PIRKLCISIVEWK-----PFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVF 390
P K WK PFE+LI+ +I N I L + + Y A D + +L+ + +F
Sbjct: 1451 PQNKQTFQYKMWKFVVSPPFEYLIMALIALNTIVLMM-KFYNAPDP--YDRMLQYLNILF 1507
Query: 391 IVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALR 570
+F++ECVLK++ G + Y R+AWN+ DF+ V+ + ++++++ ++ LR
Sbjct: 1508 TFLFSMECVLKLIGFGVL----NYFRDAWNVFDFVTVLGSITDILVTELADSFINLSFLR 1563
Query: 571 AFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHST 750
FR R ++L+ +++++L +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1564 LFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF------- 1616
Query: 751 CIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFD 930
G + D G N NF
Sbjct: 1617 ------GNIELDD------------------------------------DGAINRHNNFR 1634
Query: 931 NFGLAMLTVFQCVSLEGWTDVMYWV-------------NDAVGREWPWIYFVTLVILGSF 1071
F A++ + + + EGW ++M D G + + YFV+ + SF
Sbjct: 1635 TFLQAVMLLLRSATGEGWQEIMLACLNQSPCDARSGIDGDECGSNFAYFYFVSFIFFSSF 1694
Query: 1072 FVLNLVLGVLSGEF 1113
+LNL + V+ F
Sbjct: 1695 LMLNLFVAVIMDNF 1708
Score = 91.3 bits (225), Expect = 2e-16
Identities = 74/267 (27%), Positives = 118/267 (43%), Gaps = 18/267 (6%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLFI S N R + + F +L I+ + +LA E L M L+
Sbjct: 67 SLFIFSEDNIIRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 126
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSL-----TSFVLRTDAM 2667
+ +F +F E +K+I G FHKGS+ RN +N++D +VV + T F LRT
Sbjct: 127 EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILTTIGTDFDLRT--- 183
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
++ L+ V++ ++ A+ + I L+ F MFAIIG++ +
Sbjct: 184 -----LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY 238
Query: 2848 KGTF----FLCNDLSKMTEAECRGEYIHYEDGDPTKPVSK----KRVWSNNDF---NFDN 2994
G F F + E C +Y P++ K W+ +F NFDN
Sbjct: 239 MGKFHKTCFSEETNEPVEEFPCGTKY-------PSRLCPNGTVCKGYWNGPNFGITNFDN 291
Query: 2995 VGDAMISLFVVSTFEGWPQLLYVAIDS 3075
+ A++++F T EGW +LY A D+
Sbjct: 292 ILFAVLTVFQCITMEGWTDMLYTANDA 318
Score = 88.2 bits (217), Expect = 2e-15
Identities = 78/339 (23%), Positives = 149/339 (43%), Gaps = 8/339 (2%)
Frame = +1
Query: 250 IVEWKPFEFLILFMICAN--CIALAIY-QPYPAQDSDYKNTLLETIEYVFIVVFTIECVL 420
+V+ + F +++L ++ N C+A+ Y QP D+ Y E+VF+ +F E L
Sbjct: 468 MVKSQSFYWIVLCLVGLNTLCVAIVHYDQPPLLTDALY------FAEFVFLGLFLTEMSL 521
Query: 421 KIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQ-GFDVKALRAFRVLRPLR 597
K+ +G P Y +++N DF ++V + + + + F + LRA R+LR +
Sbjct: 522 KMYGLG----PRNYFHSSFNCFDFGVIVGSIFEVVWTAVKPDTSFGISVLRALRLLRIFK 577
Query: 598 LVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQL 777
+ SL+ ++ ++L +M ++ + L+ I+++A++G++LF GQ
Sbjct: 578 VTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLF------------GGQF 625
Query: 778 AQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTV 957
+D TP TNFD F A+LTV
Sbjct: 626 NFEDGTPP---------------------------------------TNFDTFPAAILTV 646
Query: 958 FQCVSLEGWTDVMYWVNDAVG----REWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKER 1125
FQ ++ E W +VMY+ +A G + +YF+ L + G++ +LN+ L + + +
Sbjct: 647 FQILTGEDWNEVMYYGIEAHGGVKKGMFSSVYFIILTLFGNYTLLNVFLAIAVDNLANAQ 706
Query: 1126 EKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVN 1242
E K E+ + K + + D+ P++
Sbjct: 707 E-------LTKDEEEMEEANIQKNTIQKAMEVADVSPIS 738
Score = 84.0 bits (206), Expect = 4e-14
Identities = 74/291 (25%), Positives = 123/291 (41%), Gaps = 41/291 (14%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY+I I+ N + LA + H P + LD F G+F FEA +KI+AL
Sbjct: 90 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 149
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WNV D +VV+ G L GT+ + R RV+R +KL+S
Sbjct: 150 HKGSYLRNGWNVMDFVVVL-------TGILTTIGTD-FDLRTLRAVRVLRPLKLVSGIPS 201
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQF----FGKVALDDSTSIHRN----- 3846
++ +L + MK+ L + LL+ ++A+IG++F F K + T+
Sbjct: 202 LQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKTCFSEETNEPVEEFPCG 261
Query: 3847 -------------------------NNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDV 3951
NF + A+L +F+ T E W D++ + +D
Sbjct: 262 TKYPSRLCPNGTVCKGYWNGPNFGITNFDNILFAVLTVFQCITMEGWTDMLYTAND---- 317
Query: 3952 RCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
GN + + YFI ++ SF ++NL + V+ F
Sbjct: 318 -----------------ALGNTWNWLYFIPLIVIGSFFMLNLVLGVLSGEF 351
Score = 57.8 bits (138), Expect = 3e-06
Identities = 64/332 (19%), Positives = 129/332 (38%), Gaps = 8/332 (2%)
Frame = +1
Query: 2302 TVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAA----EDPLQA 2469
++K + S + FR F +V F VL + +++ +A + PL
Sbjct: 442 SLKSVKNERSSYFRRKEKRFRFFIRRMVKSQSFYWIVLCLVGLNTLCVAIVHYDQPPLLT 501
Query: 2470 NSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFV 2649
++ L + ++ F +F E++LK+ G ++ ++FN D V+ S+ V
Sbjct: 502 DA-----LYFAEFVFLGLFLTEMSLKMYGLG----PRNYFHSSFNCFDFGVIVGSIFEVV 552
Query: 2650 ---LRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFM 2820
++ D L+++V ++ ++K+I +++ + F+ +
Sbjct: 553 WTAVKPDTSFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVV 612
Query: 2821 FAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVG 3000
FA++G+QLF G F ++EDG P NFD
Sbjct: 613 FALLGMQLFGGQF-------------------NFEDGTPPT-------------NFDTFP 640
Query: 3001 DAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXX 3180
A++++F + T E W +++Y I+++ K + +S + L
Sbjct: 641 AAILTVFQILTGEDWNEVMYYGIEAHGGVKKGMFSSVYFIILTLFGNYTLLNVFLAIAVD 700
Query: 3181 GFVIVTFQNEGEREYENCELDKNQ-RKCIEFA 3273
+ E E E + KN +K +E A
Sbjct: 701 NLANAQELTKDEEEMEEANIQKNTIQKAMEVA 732
>gi|227711|prf||1709354B voltage dependent Ca channel BI-2
Length = 2424
Score = 663 bits (1711), Expect = 0.0
Identities = 349/787 (44%), Positives = 494/787 (62%), Gaps = 17/787 (2%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
+ + E P KP+P SS+FILS TN R C+ ++N YF +L I +SS L
Sbjct: 1211 KKEEVDEGPGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIAL 1270
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP+Q N+ RN +L YFDY FT VFT E+ +K+I GLV H+G++ R+ +N+LD +VV
Sbjct: 1271 AAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVV 1330
Query: 2626 AVSLTSFVLRTDA----MSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIM 2793
+ +L +F ++ ++ I R LK V CV+ ++K + NI+
Sbjct: 1331 SGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNIL 1390
Query: 2794 LVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSN 2973
+V + F+FA++ VQLFKG FF C D SK E +CRG+Y+ YE + ++ R W
Sbjct: 1391 IVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVK---ARDREWKK 1447
Query: 2974 NDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXX 3153
+F++DNV A+++LF VST EGWPQ+L ++D+ E++GP R +++
Sbjct: 1448 YEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVF 1507
Query: 3154 XXXXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYR 3327
+I+TFQ +G++ E L+KN+R CI+FA+ AKP R++P+N+ QYR
Sbjct: 1508 PFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYR 1567
Query: 3328 VWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIV 3507
+W FV S FEY I +I +NT+ L K Y +S +++ L VFN++FT +F+ E +LK++
Sbjct: 1568 MWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYDNALKVFNIVFTSLFSLECLLKVL 1627
Query: 3508 ALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRG 3687
A NY D WN+FD + V+GS DI + G N I+++F RLFR RL+KLL +G
Sbjct: 1628 AFGILNYFRDAWNIFDFVTVLGSITDILVTEF---GNNFINLSFLRLFRAARLIKLLRQG 1684
Query: 3688 EGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALD--------DSTSIHR 3843
IR LLWTF++SF+ALPYV LLI +LFFIYA+IGMQ FG + +D D I
Sbjct: 1685 YTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDMEDEDSDEDEFQITE 1744
Query: 3844 NNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFA 4023
+NNF +F A+++LFRSATGEAW +IMLSC + CD S G+ CGN FA
Sbjct: 1745 HNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKP--CDKNS------GILTPECGNEFA 1796
Query: 4024 YPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRI 4203
Y YF+SF LCSFL++NLFVAVIMDNF+YLTRD SILGPHHL+E+VR+W+EYDP A GR+
Sbjct: 1797 YFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAAWGRM 1856
Query: 4204 KHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKI 4383
+ D+ +LR + PPLG GK CP R+A KRL+ M++P+ D TV FN+TL AL+RT L I
Sbjct: 1857 LYRDMYAMLRHMPPPLGLGKNCPARVAYKRLLRMDLPVADDNTVHFNSTLMALIRTALDI 1916
Query: 4384 -YTEGNID--EANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYF 4554
+G D + + +LR + IW + LD +V P K D+TVGK YA +I +Y+
Sbjct: 1917 KIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTP-HKSTDLTVGKIYAAMMIMEYY 1975
Query: 4555 RRFKKRK 4575
R+ K +K
Sbjct: 1976 RQSKAKK 1982
Score = 533 bits (1374), Expect = e-149
Identities = 294/667 (44%), Positives = 382/667 (57%), Gaps = 27/667 (4%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N +RK I EW PFE++IL I ANCI LA+ Q P D + L+ E FI +
Sbjct: 84 DNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGI 143
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KI+A+GF FH +YLRN WN++DF++V+ G+++T+ ++ FD++ LRA R
Sbjct: 144 FCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE-----FDLRTLRAVR 198
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQVVL +I++AMIPLL I LL+ F ILI+AIIGLE + GK H+TC +
Sbjct: 199 VLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFE 258
Query: 760 PATGQLAQKDPTPCGTD----TEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNF 927
T + + P PCGT+ T + +CQP W GPNNGIT F
Sbjct: 259 EGTDDIQGESPAPCGTEEPARTCPNGTRCQPY-----------------WEGPNNGITQF 301
Query: 928 DNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSG 1107
DN A+LTVFQC+++EGWTD++Y NDA G W W+YF+ L+I+GSFF+LNLVLGVLSG
Sbjct: 302 DNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSG 361
Query: 1108 EFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVAQTXXX 1287
EF+KERE+ R F K R QQ+E +L GY++WI++AE++ + EDE + E
Sbjct: 362 EFAKERERVENRRAFLKLRRDQQIERELNGYMEWISKAEEV-ILAEDETDVEQRHPFDGA 420
Query: 1288 XXXXXXXXXXXXXXXP-----------------SKWAARMKRLE------KLNXXXXXXX 1398
P ++ + + +LE K
Sbjct: 421 LRRATIKKSKTDLLHPEEAEDQLADIASVGSPFARASIKSAKLENSSFFHKKERRMRFYI 480
Query: 1399 XXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYS 1578
+VK+Q FYW HY Q EWL F A F+ LF EM +KMY
Sbjct: 481 RRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYG 540
Query: 1579 LGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXX 1758
LG Y S FN FDC V+I SI E + G+SVLR+ RLLRIFKVTKYW
Sbjct: 541 LGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASL 600
Query: 1759 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQAL 1938
GMQ+FGG+FNF+ + P NFDTF A+
Sbjct: 601 RNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFD--EGTPPTNFDTFPAAI 658
Query: 1939 LTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNL 2118
+TVFQILTGEDWN VMY GI+S GGV G++ IY+IVL + GNY LLNVFLAIAVDNL
Sbjct: 659 MTVFQILTGEDWNEVMYDGIKSQGGVQG-GMVFSIYFIVLTLFGNYTLLNVFLAIAVDNL 717
Query: 2119 ADADSLT 2139
A+A LT
Sbjct: 718 ANAQELT 724
Score = 171 bits (433), Expect = 2e-40
Identities = 161/660 (24%), Positives = 278/660 (41%), Gaps = 29/660 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+R+LC I+ + FE IL +I + IALA P Q + +N +L +YVF VF
Sbjct: 1240 NPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDP--VQPNAPRNNVLRYFDYVFTGVF 1297
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD---VKALRA 573
T E V+K++ +G + H AY R+ WNILDFI+V LV+ + S +G D +K+LR
Sbjct: 1298 TFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNS-KGKDINTIKSLRV 1356
Query: 574 FRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTC 753
RVLRPL+ + +P L+ V + ++ ++ + +I ++ + + I+A++ ++LF GK C
Sbjct: 1357 LRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFH-C 1415
Query: 754 IDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDN 933
D + + +KD E + K + + W+ ++DN
Sbjct: 1416 TDES--KEFEKDCRGKYLLYEKNEVKARDRE--------WKKYE-----------FHYDN 1454
Query: 934 FGLAMLTVFQCVSLEGWTDVMYWVNDAV---------GREWPWIYFVTLVILGSFFVLNL 1086
A+LT+F + EGW V+ DA R I++V ++ FF +N+
Sbjct: 1455 VLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNI 1514
Query: 1087 VLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEP 1266
+ ++ F ++ + K E+ LE++ + +D+ A+ +
Sbjct: 1515 FVALIIITFQEQGD---------KMMEEYSLEKNERACIDFAISAKPL------------ 1553
Query: 1267 VAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXX 1446
+ + + V S F +
Sbjct: 1554 -----------------------------TRHMPQNKQSFQYRMWQFVVSPPFEYTIMAM 1584
Query: 1447 XXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDC 1626
+ YG S D+ + N+ F LFS+E LLK+ + G Y +N FD
Sbjct: 1585 IALNTIVLMMKFYGASVAYDNALKVFNIVFTSLFSLECLLKVLAFGILNYFRDAWNIFDF 1644
Query: 1627 FVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXX 1806
V+ SI + ++ F + +S LR R R+ K+ +
Sbjct: 1645 VTVLGSITDILVTEFG-NNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPY 1703
Query: 1807 XXXXXXXXXXXXXXXGMQVFGG--------KFNFNPQQPKPRANFDTFVQALLTVFQILT 1962
GMQVFG + + Q NF TF QAL+ +F+ T
Sbjct: 1704 VCLLIAMLFFIYAIIGMQVFGNIGIDMEDEDSDEDEFQITEHNNFRTFFQALMLLFRSAT 1763
Query: 1963 GEDWNTVMYHGI-----ESFGGVGT--LGVIVCIYYIV--LFICGNYILLNVFLAIAVDN 2115
GE W+ +M + + G+ T G +Y V +F+C ++++LN+F+A+ +DN
Sbjct: 1764 GEAWHNIMLSCLSGKPCDKNSGILTPECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1822
Score = 120 bits (300), Expect = 5e-25
Identities = 73/274 (26%), Positives = 139/274 (50%), Gaps = 4/274 (1%)
Frame = +1
Query: 3313 RLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEA 3492
R+++ + V ++AF + + ++ +NT+ +A HY DFL IF G+F E
Sbjct: 475 RMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEM 534
Query: 3493 VLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVK 3672
+K+ L + Y +N FD V++GS ++ + + PG + I+ R R++R+ K
Sbjct: 535 FIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTS--FGISVLRALRLLRIFK 592
Query: 3673 LLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNN 3849
+ +R L+ + + S +++ + L+ L ++A++GMQ F G+ D+ T
Sbjct: 593 VTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTP---PT 649
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FPAAI+ +F+ TGE W ++M + ++ +GG+ G
Sbjct: 650 NFDTFPAAIMTVFQILTGEDWNEVMY-----DGIK--------SQGGVQ----GGMVFSI 692
Query: 4030 YFISFFMLCSFLVINLFVAVIMDNF---DYLTRD 4122
YFI + ++ ++N+F+A+ +DN LT+D
Sbjct: 693 YFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 726
Score = 95.1 bits (235), Expect = 2e-17
Identities = 71/296 (23%), Positives = 129/296 (42%), Gaps = 13/296 (4%)
Frame = +1
Query: 265 PFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFM 444
PFE+ I+ MI N I L + + Y N L + VF +F++EC+LK++A G +
Sbjct: 1576 PFEYTIMAMIALNTIVLMM--KFYGASVAYDNAL-KVFNIVFTSLFSLECLLKVLAFGIL 1632
Query: 445 FHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQ 624
Y R+AWNI DF+ V+ + ++++ ++ LR FR R ++L+ +++
Sbjct: 1633 ----NYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIR 1688
Query: 625 VVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCG 804
++L +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1689 ILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF------------------------- 1723
Query: 805 TDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGW 984
N+G+ E + NF F A++ +F+ + E W
Sbjct: 1724 ----------------GNIGIDMEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAW 1767
Query: 985 TDVMYW-------------VNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
++M + G E+ + YFV+ + L SF +LNL + V+ F
Sbjct: 1768 HNIMLSCLSGKPCDKNSGILTPECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1823
Score = 85.5 bits (210), Expect = 1e-14
Identities = 69/263 (26%), Positives = 117/263 (44%), Gaps = 13/263 (4%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLF+ S N R + + F +L I+ + +LA E L + M L+
Sbjct: 77 SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSL-----TSFVLRTDAM 2667
+ +F +F E +K+I G FHKGS+ RN +N++D +VV + T F LRT
Sbjct: 137 EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRT--- 193
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
++ L+ V++ ++ A+ + I L+ F +FAIIG++ +
Sbjct: 194 -----LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFY 248
Query: 2848 KGTFFL------CNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAM 3009
G F +D+ + A C E + T+ +N FDN+ A+
Sbjct: 249 MGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTRCQPYWEGPNNGITQFDNILFAV 308
Query: 3010 ISLFVVSTFEGWPQLLYVAIDSN 3078
+++F T EGW LLY + D++
Sbjct: 309 LTVFQCITMEGWTDLLYNSNDAS 331
Score = 80.9 bits (198), Expect = 3e-13
Identities = 75/293 (25%), Positives = 123/293 (41%), Gaps = 43/293 (14%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY+I I+ N + LA + H P + LD F G+F FEA +KI+AL
Sbjct: 100 FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WNV D +VV+ G L GT + R RV+R +KL+S
Sbjct: 160 HKGSYLRNGWNVMDFVVVL-------TGILATVGTE-FDLRTLRAVRVLRPLKLVSGIPS 211
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQF----FGKVALDDSTSIHR------ 3843
++ +L + MK+ L + LL+ I+A+IG++F F ++ T +
Sbjct: 212 LQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAP 271
Query: 3844 -----------------------NN---NFHSFPAAILVLFRSATGEAWQDIMLSCSDRE 3945
NN F + A+L +F+ T E W D++ + +D
Sbjct: 272 CGTEEPARTCPNGTRCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDAS 331
Query: 3946 DVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
GN + + YFI ++ SF ++NL + V+ F
Sbjct: 332 ---------------------GNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 363
Score = 45.8 bits (107), Expect = 0.012
Identities = 50/264 (18%), Positives = 103/264 (38%), Gaps = 3/264 (1%)
Frame = +1
Query: 2293 AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN 2472
A +++K +S F R + +V F VL + +++ +A Q
Sbjct: 454 ARASIKSAKLENSSFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPE 513
Query: 2473 STRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL 2652
+ L Y ++ F +F E+ +K+ G + ++FN D V+ S+ +
Sbjct: 514 WLSDF-LYYAEFIFLGLFMSEMFIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIW 568
Query: 2653 RTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
K L+++V ++ ++K+I +++ + F+ +F
Sbjct: 569 AVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
Query: 2824 AIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGD 3003
A++G+QLF G F ++++G P NFD
Sbjct: 629 ALLGMQLFGGQF-------------------NFDEGTPPT-------------NFDTFPA 656
Query: 3004 AMISLFVVSTFEGWPQLLYVAIDS 3075
A++++F + T E W +++Y I S
Sbjct: 657 AIMTVFQILTGEDWNEVMYDGIKS 680
>gi|399201|sp|P27884|CCAA_RABIT Voltage-dependent P/Q-type calcium
channel alpha-1A subunit (Voltage-gated calcium channel
alpha subunit Cav2.1) (Calcium channel, L type, alpha-1
polypeptide isoform 4) (Brain calcium channel I) (BI)
gi|1527|emb|CAA40715.1| calcium channel BI-2 [Oryctolagus cuniculus]
Length = 2424
Score = 663 bits (1711), Expect = 0.0
Identities = 349/787 (44%), Positives = 494/787 (62%), Gaps = 17/787 (2%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
+ + E P KP+P SS+FILS TN R C+ ++N YF +L I +SS L
Sbjct: 1211 KKEEVDEGPGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIAL 1270
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP+Q N+ RN +L YFDY FT VFT E+ +K+I GLV H+G++ R+ +N+LD +VV
Sbjct: 1271 AAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVV 1330
Query: 2626 AVSLTSFVLRTDA----MSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIM 2793
+ +L +F ++ ++ I R LK V CV+ ++K + NI+
Sbjct: 1331 SGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNIL 1390
Query: 2794 LVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSN 2973
+V + F+FA++ VQLFKG FF C D SK E +CRG+Y+ YE + ++ R W
Sbjct: 1391 IVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVK---ARDREWKK 1447
Query: 2974 NDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXX 3153
+F++DNV A+++LF VST EGWPQ+L ++D+ E++GP R +++
Sbjct: 1448 YEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVF 1507
Query: 3154 XXXXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYR 3327
+I+TFQ +G++ E L+KN+R CI+FA+ AKP R++P+N+ QYR
Sbjct: 1508 PFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYR 1567
Query: 3328 VWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIV 3507
+W FV S FEY I +I +NT+ L K Y +S +++ L VFN++FT +F+ E +LK++
Sbjct: 1568 MWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYDNALKVFNIVFTSLFSLECLLKVL 1627
Query: 3508 ALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRG 3687
A NY D WN+FD + V+GS DI + G N I+++F RLFR RL+KLL +G
Sbjct: 1628 AFGILNYFRDAWNIFDFVTVLGSITDILVTEF---GNNFINLSFLRLFRAARLIKLLRQG 1684
Query: 3688 EGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALD--------DSTSIHR 3843
IR LLWTF++SF+ALPYV LLI +LFFIYA+IGMQ FG + +D D I
Sbjct: 1685 YTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDMEDEDSDEDEFQITE 1744
Query: 3844 NNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFA 4023
+NNF +F A+++LFRSATGEAW +IMLSC + CD S G+ CGN FA
Sbjct: 1745 HNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKP--CDKNS------GILTPECGNEFA 1796
Query: 4024 YPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRI 4203
Y YF+SF LCSFL++NLFVAVIMDNF+YLTRD SILGPHHL+E+VR+W+EYDP A GR+
Sbjct: 1797 YFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAAWGRM 1856
Query: 4204 KHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKI 4383
+ D+ +LR + PPLG GK CP R+A KRL+ M++P+ D TV FN+TL AL+RT L I
Sbjct: 1857 LYRDMYAMLRHMPPPLGLGKNCPARVAYKRLLRMDLPVADDNTVHFNSTLMALIRTALDI 1916
Query: 4384 -YTEGNID--EANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYF 4554
+G D + + +LR + IW + LD +V P K D+TVGK YA +I +Y+
Sbjct: 1917 KIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTP-HKSTDLTVGKIYAAMMIMEYY 1975
Query: 4555 RRFKKRK 4575
R+ K +K
Sbjct: 1976 RQSKAKK 1982
Score = 534 bits (1376), Expect = e-150
Identities = 294/667 (44%), Positives = 383/667 (57%), Gaps = 27/667 (4%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N +RK I EW PFE++IL I ANCI LA+ Q P D + L+ E FI +
Sbjct: 84 DNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGI 143
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KI+A+GF FH +YLRN WN++DF++V+ G+++T+ ++ FD++ LRA R
Sbjct: 144 FCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE-----FDLRTLRAVR 198
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQVVL +I++AMIPLL I LL+ F ILI+AIIGLE + GK H+TC +
Sbjct: 199 VLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFE 258
Query: 760 PATGQLAQKDPTPCGTD----TEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNF 927
T + + P PCGT+ T + +CQP W GPNNGIT F
Sbjct: 259 EGTDDIQGESPAPCGTEEPARTCPNGTRCQPY-----------------WEGPNNGITQF 301
Query: 928 DNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSG 1107
DN A+LTVFQC+++EGWTD++Y NDA G W W+YF+ L+I+GSFF+LNLVLGVLSG
Sbjct: 302 DNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSG 361
Query: 1108 EFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVAQTXXX 1287
EF+KERE+ R F K R +QQ+E +L GY++WI++AE++ + EDE + E
Sbjct: 362 EFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEV-ILAEDETDVEQRHPFDGA 420
Query: 1288 XXXXXXXXXXXXXXXP-----------------SKWAARMKRLE------KLNXXXXXXX 1398
P ++ + + +LE K
Sbjct: 421 LRRATIKKSKTDLLHPEEAEDQLADIASVGSPFARASIKSAKLENSSFFHKKERRMRFYI 480
Query: 1399 XXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYS 1578
+VK+Q FYW HY Q EWL F A F+ LF EM +KMY
Sbjct: 481 RRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYG 540
Query: 1579 LGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXX 1758
LG Y S FN FDC V+I SI E + G+SVLR+ RLLRIFKVTKYW
Sbjct: 541 LGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASL 600
Query: 1759 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQAL 1938
GMQ+FGG+FNF+ + P NFDTF A+
Sbjct: 601 RNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFD--EGTPPTNFDTFPAAI 658
Query: 1939 LTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNL 2118
+TVFQILTGEDWN VMY GI+S GGV G++ IY+IVL + GNY LLNVFLAIAVDNL
Sbjct: 659 MTVFQILTGEDWNEVMYDGIKSQGGVQG-GMVFSIYFIVLTLFGNYTLLNVFLAIAVDNL 717
Query: 2119 ADADSLT 2139
A+A LT
Sbjct: 718 ANAQELT 724
Score = 171 bits (433), Expect = 2e-40
Identities = 161/660 (24%), Positives = 278/660 (41%), Gaps = 29/660 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+R+LC I+ + FE IL +I + IALA P Q + +N +L +YVF VF
Sbjct: 1240 NPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDP--VQPNAPRNNVLRYFDYVFTGVF 1297
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD---VKALRA 573
T E V+K++ +G + H AY R+ WNILDFI+V LV+ + S +G D +K+LR
Sbjct: 1298 TFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNS-KGKDINTIKSLRV 1356
Query: 574 FRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTC 753
RVLRPL+ + +P L+ V + ++ ++ + +I ++ + + I+A++ ++LF GK C
Sbjct: 1357 LRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFH-C 1415
Query: 754 IDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDN 933
D + + +KD E + K + + W+ ++DN
Sbjct: 1416 TDES--KEFEKDCRGKYLLYEKNEVKARDRE--------WKKYE-----------FHYDN 1454
Query: 934 FGLAMLTVFQCVSLEGWTDVMYWVNDAV---------GREWPWIYFVTLVILGSFFVLNL 1086
A+LT+F + EGW V+ DA R I++V ++ FF +N+
Sbjct: 1455 VLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNI 1514
Query: 1087 VLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEP 1266
+ ++ F ++ + K E+ LE++ + +D+ A+ +
Sbjct: 1515 FVALIIITFQEQGD---------KMMEEYSLEKNERACIDFAISAKPL------------ 1553
Query: 1267 VAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXX 1446
+ + + V S F +
Sbjct: 1554 -----------------------------TRHMPQNKQSFQYRMWQFVVSPPFEYTIMAM 1584
Query: 1447 XXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDC 1626
+ YG S D+ + N+ F LFS+E LLK+ + G Y +N FD
Sbjct: 1585 IALNTIVLMMKFYGASVAYDNALKVFNIVFTSLFSLECLLKVLAFGILNYFRDAWNIFDF 1644
Query: 1627 FVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXX 1806
V+ SI + ++ F + +S LR R R+ K+ +
Sbjct: 1645 VTVLGSITDILVTEFG-NNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPY 1703
Query: 1807 XXXXXXXXXXXXXXXGMQVFGG--------KFNFNPQQPKPRANFDTFVQALLTVFQILT 1962
GMQVFG + + Q NF TF QAL+ +F+ T
Sbjct: 1704 VCLLIAMLFFIYAIIGMQVFGNIGIDMEDEDSDEDEFQITEHNNFRTFFQALMLLFRSAT 1763
Query: 1963 GEDWNTVMYHGI-----ESFGGVGT--LGVIVCIYYIV--LFICGNYILLNVFLAIAVDN 2115
GE W+ +M + + G+ T G +Y V +F+C ++++LN+F+A+ +DN
Sbjct: 1764 GEAWHNIMLSCLSGKPCDKNSGILTPECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1822
Score = 120 bits (300), Expect = 5e-25
Identities = 73/274 (26%), Positives = 139/274 (50%), Gaps = 4/274 (1%)
Frame = +1
Query: 3313 RLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEA 3492
R+++ + V ++AF + + ++ +NT+ +A HY DFL IF G+F E
Sbjct: 475 RMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEM 534
Query: 3493 VLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVK 3672
+K+ L + Y +N FD V++GS ++ + + PG + I+ R R++R+ K
Sbjct: 535 FIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTS--FGISVLRALRLLRIFK 592
Query: 3673 LLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNN 3849
+ +R L+ + + S +++ + L+ L ++A++GMQ F G+ D+ T
Sbjct: 593 VTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTP---PT 649
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FPAAI+ +F+ TGE W ++M + ++ +GG+ G
Sbjct: 650 NFDTFPAAIMTVFQILTGEDWNEVMY-----DGIK--------SQGGVQ----GGMVFSI 692
Query: 4030 YFISFFMLCSFLVINLFVAVIMDNF---DYLTRD 4122
YFI + ++ ++N+F+A+ +DN LT+D
Sbjct: 693 YFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 726
Score = 95.1 bits (235), Expect = 2e-17
Identities = 71/296 (23%), Positives = 129/296 (42%), Gaps = 13/296 (4%)
Frame = +1
Query: 265 PFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFM 444
PFE+ I+ MI N I L + + Y N L + VF +F++EC+LK++A G +
Sbjct: 1576 PFEYTIMAMIALNTIVLMM--KFYGASVAYDNAL-KVFNIVFTSLFSLECLLKVLAFGIL 1632
Query: 445 FHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQ 624
Y R+AWNI DF+ V+ + ++++ ++ LR FR R ++L+ +++
Sbjct: 1633 ----NYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIR 1688
Query: 625 VVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCG 804
++L +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1689 ILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF------------------------- 1723
Query: 805 TDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGW 984
N+G+ E + NF F A++ +F+ + E W
Sbjct: 1724 ----------------GNIGIDMEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAW 1767
Query: 985 TDVMYW-------------VNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
++M + G E+ + YFV+ + L SF +LNL + V+ F
Sbjct: 1768 HNIMLSCLSGKPCDKNSGILTPECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1823
Score = 85.5 bits (210), Expect = 1e-14
Identities = 69/263 (26%), Positives = 117/263 (44%), Gaps = 13/263 (4%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLF+ S N R + + F +L I+ + +LA E L + M L+
Sbjct: 77 SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSL-----TSFVLRTDAM 2667
+ +F +F E +K+I G FHKGS+ RN +N++D +VV + T F LRT
Sbjct: 137 EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRT--- 193
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
++ L+ V++ ++ A+ + I L+ F +FAIIG++ +
Sbjct: 194 -----LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFY 248
Query: 2848 KGTFFL------CNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAM 3009
G F +D+ + A C E + T+ +N FDN+ A+
Sbjct: 249 MGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTRCQPYWEGPNNGITQFDNILFAV 308
Query: 3010 ISLFVVSTFEGWPQLLYVAIDSN 3078
+++F T EGW LLY + D++
Sbjct: 309 LTVFQCITMEGWTDLLYNSNDAS 331
Score = 80.9 bits (198), Expect = 3e-13
Identities = 75/293 (25%), Positives = 123/293 (41%), Gaps = 43/293 (14%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY+I I+ N + LA + H P + LD F G+F FEA +KI+AL
Sbjct: 100 FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WNV D +VV+ G L GT + R RV+R +KL+S
Sbjct: 160 HKGSYLRNGWNVMDFVVVL-------TGILATVGTE-FDLRTLRAVRVLRPLKLVSGIPS 211
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQF----FGKVALDDSTSIHR------ 3843
++ +L + MK+ L + LL+ I+A+IG++F F ++ T +
Sbjct: 212 LQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAP 271
Query: 3844 -----------------------NN---NFHSFPAAILVLFRSATGEAWQDIMLSCSDRE 3945
NN F + A+L +F+ T E W D++ + +D
Sbjct: 272 CGTEEPARTCPNGTRCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDAS 331
Query: 3946 DVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
GN + + YFI ++ SF ++NL + V+ F
Sbjct: 332 ---------------------GNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 363
Score = 45.8 bits (107), Expect = 0.012
Identities = 50/264 (18%), Positives = 103/264 (38%), Gaps = 3/264 (1%)
Frame = +1
Query: 2293 AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN 2472
A +++K +S F R + +V F VL + +++ +A Q
Sbjct: 454 ARASIKSAKLENSSFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPE 513
Query: 2473 STRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL 2652
+ L Y ++ F +F E+ +K+ G + ++FN D V+ S+ +
Sbjct: 514 WLSDF-LYYAEFIFLGLFMSEMFIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIW 568
Query: 2653 RTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
K L+++V ++ ++K+I +++ + F+ +F
Sbjct: 569 AVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
Query: 2824 AIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGD 3003
A++G+QLF G F ++++G P NFD
Sbjct: 629 ALLGMQLFGGQF-------------------NFDEGTPPT-------------NFDTFPA 656
Query: 3004 AMISLFVVSTFEGWPQLLYVAIDS 3075
A++++F + T E W +++Y I S
Sbjct: 657 AIMTVFQILTGEDWNEVMYDGIKS 680
>gi|2136947|pir||I46477 calcium channel BI-1 - rabbit
gi|1523|emb|CAA40714.1| calcium channel BI-1 [Oryctolagus cuniculus]
Length = 2273
Score = 663 bits (1711), Expect = 0.0
Identities = 349/787 (44%), Positives = 494/787 (62%), Gaps = 17/787 (2%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
+ + E P KP+P SS+FILS TN R C+ ++N YF +L I +SS L
Sbjct: 1211 KKEEVDEGPGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIAL 1270
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP+Q N+ RN +L YFDY FT VFT E+ +K+I GLV H+G++ R+ +N+LD +VV
Sbjct: 1271 AAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVV 1330
Query: 2626 AVSLTSFVLRTDA----MSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIM 2793
+ +L +F ++ ++ I R LK V CV+ ++K + NI+
Sbjct: 1331 SGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNIL 1390
Query: 2794 LVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSN 2973
+V + F+FA++ VQLFKG FF C D SK E +CRG+Y+ YE + ++ R W
Sbjct: 1391 IVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVK---ARDREWKK 1447
Query: 2974 NDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXX 3153
+F++DNV A+++LF VST EGWPQ+L ++D+ E++GP R +++
Sbjct: 1448 YEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVF 1507
Query: 3154 XXXXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYR 3327
+I+TFQ +G++ E L+KN+R CI+FA+ AKP R++P+N+ QYR
Sbjct: 1508 PFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYR 1567
Query: 3328 VWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIV 3507
+W FV S FEY I +I +NT+ L K Y +S +++ L VFN++FT +F+ E +LK++
Sbjct: 1568 MWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYDNALKVFNIVFTSLFSLECLLKVL 1627
Query: 3508 ALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRG 3687
A NY D WN+FD + V+GS DI + G N I+++F RLFR RL+KLL +G
Sbjct: 1628 AFGILNYFRDAWNIFDFVTVLGSITDILVTEF---GNNFINLSFLRLFRAARLIKLLRQG 1684
Query: 3688 EGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALD--------DSTSIHR 3843
IR LLWTF++SF+ALPYV LLI +LFFIYA+IGMQ FG + +D D I
Sbjct: 1685 YTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDMEDEDSDEDEFQITE 1744
Query: 3844 NNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFA 4023
+NNF +F A+++LFRSATGEAW +IMLSC + CD S G+ CGN FA
Sbjct: 1745 HNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKP--CDKNS------GILTPECGNEFA 1796
Query: 4024 YPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRI 4203
Y YF+SF LCSFL++NLFVAVIMDNF+YLTRD SILGPHHL+E+VR+W+EYDP A GR+
Sbjct: 1797 YFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAAWGRM 1856
Query: 4204 KHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKI 4383
+ D+ +LR + PPLG GK CP R+A KRL+ M++P+ D TV FN+TL AL+RT L I
Sbjct: 1857 LYRDMYAMLRHMPPPLGLGKNCPARVAYKRLLRMDLPVADDNTVHFNSTLMALIRTALDI 1916
Query: 4384 -YTEGNID--EANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYF 4554
+G D + + +LR + IW + LD +V P K D+TVGK YA +I +Y+
Sbjct: 1917 KIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTP-HKSTDLTVGKIYAAMMIMEYY 1975
Query: 4555 RRFKKRK 4575
R+ K +K
Sbjct: 1976 RQSKAKK 1982
Score = 534 bits (1376), Expect = e-150
Identities = 294/667 (44%), Positives = 383/667 (57%), Gaps = 27/667 (4%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N +RK I EW PFE++IL I ANCI LA+ Q P D + L+ E FI +
Sbjct: 84 DNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGI 143
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KI+A+GF FH +YLRN WN++DF++V+ G+++T+ ++ FD++ LRA R
Sbjct: 144 FCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE-----FDLRTLRAVR 198
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQVVL +I++AMIPLL I LL+ F ILI+AIIGLE + GK H+TC +
Sbjct: 199 VLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFE 258
Query: 760 PATGQLAQKDPTPCGTD----TEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNF 927
T + + P PCGT+ T + +CQP W GPNNGIT F
Sbjct: 259 EGTDDIQGESPAPCGTEEPARTCPNGTRCQPY-----------------WEGPNNGITQF 301
Query: 928 DNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSG 1107
DN A+LTVFQC+++EGWTD++Y NDA G W W+YF+ L+I+GSFF+LNLVLGVLSG
Sbjct: 302 DNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSG 361
Query: 1108 EFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVAQTXXX 1287
EF+KERE+ R F K R +QQ+E +L GY++WI++AE++ + EDE + E
Sbjct: 362 EFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEV-ILAEDETDVEQRHPFDGA 420
Query: 1288 XXXXXXXXXXXXXXXP-----------------SKWAARMKRLE------KLNXXXXXXX 1398
P ++ + + +LE K
Sbjct: 421 LRRATIKKSKTDLLHPEEAEDQLADIASVGSPFARASIKSAKLENSSFFHKKERRMRFYI 480
Query: 1399 XXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYS 1578
+VK+Q FYW HY Q EWL F A F+ LF EM +KMY
Sbjct: 481 RRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYG 540
Query: 1579 LGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXX 1758
LG Y S FN FDC V+I SI E + G+SVLR+ RLLRIFKVTKYW
Sbjct: 541 LGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASL 600
Query: 1759 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQAL 1938
GMQ+FGG+FNF+ + P NFDTF A+
Sbjct: 601 RNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFD--EGTPPTNFDTFPAAI 658
Query: 1939 LTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNL 2118
+TVFQILTGEDWN VMY GI+S GGV G++ IY+IVL + GNY LLNVFLAIAVDNL
Sbjct: 659 MTVFQILTGEDWNEVMYDGIKSQGGVQG-GMVFSIYFIVLTLFGNYTLLNVFLAIAVDNL 717
Query: 2119 ADADSLT 2139
A+A LT
Sbjct: 718 ANAQELT 724
Score = 171 bits (433), Expect = 2e-40
Identities = 161/660 (24%), Positives = 278/660 (41%), Gaps = 29/660 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+R+LC I+ + FE IL +I + IALA P Q + +N +L +YVF VF
Sbjct: 1240 NPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDP--VQPNAPRNNVLRYFDYVFTGVF 1297
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD---VKALRA 573
T E V+K++ +G + H AY R+ WNILDFI+V LV+ + S +G D +K+LR
Sbjct: 1298 TFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNS-KGKDINTIKSLRV 1356
Query: 574 FRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTC 753
RVLRPL+ + +P L+ V + ++ ++ + +I ++ + + I+A++ ++LF GK C
Sbjct: 1357 LRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFH-C 1415
Query: 754 IDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDN 933
D + + +KD E + K + + W+ ++DN
Sbjct: 1416 TDES--KEFEKDCRGKYLLYEKNEVKARDRE--------WKKYE-----------FHYDN 1454
Query: 934 FGLAMLTVFQCVSLEGWTDVMYWVNDAV---------GREWPWIYFVTLVILGSFFVLNL 1086
A+LT+F + EGW V+ DA R I++V ++ FF +N+
Sbjct: 1455 VLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNI 1514
Query: 1087 VLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEP 1266
+ ++ F ++ + K E+ LE++ + +D+ A+ +
Sbjct: 1515 FVALIIITFQEQGD---------KMMEEYSLEKNERACIDFAISAKPL------------ 1553
Query: 1267 VAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXX 1446
+ + + V S F +
Sbjct: 1554 -----------------------------TRHMPQNKQSFQYRMWQFVVSPPFEYTIMAM 1584
Query: 1447 XXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDC 1626
+ YG S D+ + N+ F LFS+E LLK+ + G Y +N FD
Sbjct: 1585 IALNTIVLMMKFYGASVAYDNALKVFNIVFTSLFSLECLLKVLAFGILNYFRDAWNIFDF 1644
Query: 1627 FVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXX 1806
V+ SI + ++ F + +S LR R R+ K+ +
Sbjct: 1645 VTVLGSITDILVTEFG-NNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPY 1703
Query: 1807 XXXXXXXXXXXXXXXGMQVFGG--------KFNFNPQQPKPRANFDTFVQALLTVFQILT 1962
GMQVFG + + Q NF TF QAL+ +F+ T
Sbjct: 1704 VCLLIAMLFFIYAIIGMQVFGNIGIDMEDEDSDEDEFQITEHNNFRTFFQALMLLFRSAT 1763
Query: 1963 GEDWNTVMYHGI-----ESFGGVGT--LGVIVCIYYIV--LFICGNYILLNVFLAIAVDN 2115
GE W+ +M + + G+ T G +Y V +F+C ++++LN+F+A+ +DN
Sbjct: 1764 GEAWHNIMLSCLSGKPCDKNSGILTPECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1822
Score = 120 bits (300), Expect = 5e-25
Identities = 73/274 (26%), Positives = 139/274 (50%), Gaps = 4/274 (1%)
Frame = +1
Query: 3313 RLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEA 3492
R+++ + V ++AF + + ++ +NT+ +A HY DFL IF G+F E
Sbjct: 475 RMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEM 534
Query: 3493 VLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVK 3672
+K+ L + Y +N FD V++GS ++ + + PG + I+ R R++R+ K
Sbjct: 535 FIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTS--FGISVLRALRLLRIFK 592
Query: 3673 LLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNN 3849
+ +R L+ + + S +++ + L+ L ++A++GMQ F G+ D+ T
Sbjct: 593 VTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTP---PT 649
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FPAAI+ +F+ TGE W ++M + ++ +GG+ G
Sbjct: 650 NFDTFPAAIMTVFQILTGEDWNEVMY-----DGIK--------SQGGVQ----GGMVFSI 692
Query: 4030 YFISFFMLCSFLVINLFVAVIMDNF---DYLTRD 4122
YFI + ++ ++N+F+A+ +DN LT+D
Sbjct: 693 YFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 726
Score = 95.1 bits (235), Expect = 2e-17
Identities = 71/296 (23%), Positives = 129/296 (42%), Gaps = 13/296 (4%)
Frame = +1
Query: 265 PFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFM 444
PFE+ I+ MI N I L + + Y N L + VF +F++EC+LK++A G +
Sbjct: 1576 PFEYTIMAMIALNTIVLMM--KFYGASVAYDNAL-KVFNIVFTSLFSLECLLKVLAFGIL 1632
Query: 445 FHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQ 624
Y R+AWNI DF+ V+ + ++++ ++ LR FR R ++L+ +++
Sbjct: 1633 ----NYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIR 1688
Query: 625 VVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCG 804
++L +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1689 ILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF------------------------- 1723
Query: 805 TDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGW 984
N+G+ E + NF F A++ +F+ + E W
Sbjct: 1724 ----------------GNIGIDMEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAW 1767
Query: 985 TDVMYW-------------VNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
++M + G E+ + YFV+ + L SF +LNL + V+ F
Sbjct: 1768 HNIMLSCLSGKPCDKNSGILTPECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1823
Score = 85.5 bits (210), Expect = 1e-14
Identities = 69/263 (26%), Positives = 117/263 (44%), Gaps = 13/263 (4%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLF+ S N R + + F +L I+ + +LA E L + M L+
Sbjct: 77 SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSL-----TSFVLRTDAM 2667
+ +F +F E +K+I G FHKGS+ RN +N++D +VV + T F LRT
Sbjct: 137 EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRT--- 193
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
++ L+ V++ ++ A+ + I L+ F +FAIIG++ +
Sbjct: 194 -----LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFY 248
Query: 2848 KGTFFL------CNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAM 3009
G F +D+ + A C E + T+ +N FDN+ A+
Sbjct: 249 MGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTRCQPYWEGPNNGITQFDNILFAV 308
Query: 3010 ISLFVVSTFEGWPQLLYVAIDSN 3078
+++F T EGW LLY + D++
Sbjct: 309 LTVFQCITMEGWTDLLYNSNDAS 331
Score = 80.9 bits (198), Expect = 3e-13
Identities = 75/293 (25%), Positives = 123/293 (41%), Gaps = 43/293 (14%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY+I I+ N + LA + H P + LD F G+F FEA +KI+AL
Sbjct: 100 FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WNV D +VV+ G L GT + R RV+R +KL+S
Sbjct: 160 HKGSYLRNGWNVMDFVVVL-------TGILATVGTE-FDLRTLRAVRVLRPLKLVSGIPS 211
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQF----FGKVALDDSTSIHR------ 3843
++ +L + MK+ L + LL+ I+A+IG++F F ++ T +
Sbjct: 212 LQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAP 271
Query: 3844 -----------------------NN---NFHSFPAAILVLFRSATGEAWQDIMLSCSDRE 3945
NN F + A+L +F+ T E W D++ + +D
Sbjct: 272 CGTEEPARTCPNGTRCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDAS 331
Query: 3946 DVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
GN + + YFI ++ SF ++NL + V+ F
Sbjct: 332 ---------------------GNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 363
Score = 45.8 bits (107), Expect = 0.012
Identities = 50/264 (18%), Positives = 103/264 (38%), Gaps = 3/264 (1%)
Frame = +1
Query: 2293 AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN 2472
A +++K +S F R + +V F VL + +++ +A Q
Sbjct: 454 ARASIKSAKLENSSFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPE 513
Query: 2473 STRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL 2652
+ L Y ++ F +F E+ +K+ G + ++FN D V+ S+ +
Sbjct: 514 WLSDF-LYYAEFIFLGLFMSEMFIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIW 568
Query: 2653 RTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
K L+++V ++ ++K+I +++ + F+ +F
Sbjct: 569 AVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
Query: 2824 AIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGD 3003
A++G+QLF G F ++++G P NFD
Sbjct: 629 ALLGMQLFGGQF-------------------NFDEGTPPT-------------NFDTFPA 656
Query: 3004 AMISLFVVSTFEGWPQLLYVAIDS 3075
A++++F + T E W +++Y I S
Sbjct: 657 AIMTVFQILTGEDWNEVMYDGIKS 680
>gi|227710|prf||1709354A voltage dependent Ca channel BI-1
Length = 2273
Score = 663 bits (1711), Expect = 0.0
Identities = 349/787 (44%), Positives = 494/787 (62%), Gaps = 17/787 (2%)
Frame = +1
Query: 2266 RPRRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAML 2445
+ + E P KP+P SS+FILS TN R C+ ++N YF +L I +SS L
Sbjct: 1211 KKEEVDEGPGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIAL 1270
Query: 2446 AAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV 2625
AAEDP+Q N+ RN +L YFDY FT VFT E+ +K+I GLV H+G++ R+ +N+LD +VV
Sbjct: 1271 AAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVV 1330
Query: 2626 AVSLTSFVLRTDA----MSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIM 2793
+ +L +F ++ ++ I R LK V CV+ ++K + NI+
Sbjct: 1331 SGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNIL 1390
Query: 2794 LVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSN 2973
+V + F+FA++ VQLFKG FF C D SK E +CRG+Y+ YE + ++ R W
Sbjct: 1391 IVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVK---ARDREWKK 1447
Query: 2974 NDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXX 3153
+F++DNV A+++LF VST EGWPQ+L ++D+ E++GP R +++
Sbjct: 1448 YEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVF 1507
Query: 3154 XXXXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYR 3327
+I+TFQ +G++ E L+KN+R CI+FA+ AKP R++P+N+ QYR
Sbjct: 1508 PFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYR 1567
Query: 3328 VWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIV 3507
+W FV S FEY I +I +NT+ L K Y +S +++ L VFN++FT +F+ E +LK++
Sbjct: 1568 MWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYDNALKVFNIVFTSLFSLECLLKVL 1627
Query: 3508 ALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRG 3687
A NY D WN+FD + V+GS DI + G N I+++F RLFR RL+KLL +G
Sbjct: 1628 AFGILNYFRDAWNIFDFVTVLGSITDILVTEF---GNNFINLSFLRLFRAARLIKLLRQG 1684
Query: 3688 EGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALD--------DSTSIHR 3843
IR LLWTF++SF+ALPYV LLI +LFFIYA+IGMQ FG + +D D I
Sbjct: 1685 YTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDMEDEDSDEDEFQITE 1744
Query: 3844 NNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFA 4023
+NNF +F A+++LFRSATGEAW +IMLSC + CD S G+ CGN FA
Sbjct: 1745 HNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKP--CDKNS------GILTPECGNEFA 1796
Query: 4024 YPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRI 4203
Y YF+SF LCSFL++NLFVAVIMDNF+YLTRD SILGPHHL+E+VR+W+EYDP A GR+
Sbjct: 1797 YFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAAWGRM 1856
Query: 4204 KHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKI 4383
+ D+ +LR + PPLG GK CP R+A KRL+ M++P+ D TV FN+TL AL+RT L I
Sbjct: 1857 LYRDMYAMLRHMPPPLGLGKNCPARVAYKRLLRMDLPVADDNTVHFNSTLMALIRTALDI 1916
Query: 4384 -YTEGNID--EANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYF 4554
+G D + + +LR + IW + LD +V P K D+TVGK YA +I +Y+
Sbjct: 1917 KIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTP-HKSTDLTVGKIYAAMMIMEYY 1975
Query: 4555 RRFKKRK 4575
R+ K +K
Sbjct: 1976 RQSKAKK 1982
Score = 533 bits (1374), Expect = e-149
Identities = 294/667 (44%), Positives = 382/667 (57%), Gaps = 27/667 (4%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N +RK I EW PFE++IL I ANCI LA+ Q P D + L+ E FI +
Sbjct: 84 DNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGI 143
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KI+A+GF FH +YLRN WN++DF++V+ G+++T+ ++ FD++ LRA R
Sbjct: 144 FCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE-----FDLRTLRAVR 198
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQVVL +I++AMIPLL I LL+ F ILI+AIIGLE + GK H+TC +
Sbjct: 199 VLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFE 258
Query: 760 PATGQLAQKDPTPCGTD----TEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNF 927
T + + P PCGT+ T + +CQP W GPNNGIT F
Sbjct: 259 EGTDDIQGESPAPCGTEEPARTCPNGTRCQPY-----------------WEGPNNGITQF 301
Query: 928 DNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSG 1107
DN A+LTVFQC+++EGWTD++Y NDA G W W+YF+ L+I+GSFF+LNLVLGVLSG
Sbjct: 302 DNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSG 361
Query: 1108 EFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVAQTXXX 1287
EF+KERE+ R F K R QQ+E +L GY++WI++AE++ + EDE + E
Sbjct: 362 EFAKERERVENRRAFLKLRRDQQIERELNGYMEWISKAEEV-ILAEDETDVEQRHPFDGA 420
Query: 1288 XXXXXXXXXXXXXXXP-----------------SKWAARMKRLE------KLNXXXXXXX 1398
P ++ + + +LE K
Sbjct: 421 LRRATIKKSKTDLLHPEEAEDQLADIASVGSPFARASIKSAKLENSSFFHKKERRMRFYI 480
Query: 1399 XXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYS 1578
+VK+Q FYW HY Q EWL F A F+ LF EM +KMY
Sbjct: 481 RRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYG 540
Query: 1579 LGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXX 1758
LG Y S FN FDC V+I SI E + G+SVLR+ RLLRIFKVTKYW
Sbjct: 541 LGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASL 600
Query: 1759 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQAL 1938
GMQ+FGG+FNF+ + P NFDTF A+
Sbjct: 601 RNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFD--EGTPPTNFDTFPAAI 658
Query: 1939 LTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNL 2118
+TVFQILTGEDWN VMY GI+S GGV G++ IY+IVL + GNY LLNVFLAIAVDNL
Sbjct: 659 MTVFQILTGEDWNEVMYDGIKSQGGVQG-GMVFSIYFIVLTLFGNYTLLNVFLAIAVDNL 717
Query: 2119 ADADSLT 2139
A+A LT
Sbjct: 718 ANAQELT 724
Score = 171 bits (433), Expect = 2e-40
Identities = 161/660 (24%), Positives = 278/660 (41%), Gaps = 29/660 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+R+LC I+ + FE IL +I + IALA P Q + +N +L +YVF VF
Sbjct: 1240 NPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDP--VQPNAPRNNVLRYFDYVFTGVF 1297
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD---VKALRA 573
T E V+K++ +G + H AY R+ WNILDFI+V LV+ + S +G D +K+LR
Sbjct: 1298 TFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNS-KGKDINTIKSLRV 1356
Query: 574 FRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTC 753
RVLRPL+ + +P L+ V + ++ ++ + +I ++ + + I+A++ ++LF GK C
Sbjct: 1357 LRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFH-C 1415
Query: 754 IDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDN 933
D + + +KD E + K + + W+ ++DN
Sbjct: 1416 TDES--KEFEKDCRGKYLLYEKNEVKARDRE--------WKKYE-----------FHYDN 1454
Query: 934 FGLAMLTVFQCVSLEGWTDVMYWVNDAV---------GREWPWIYFVTLVILGSFFVLNL 1086
A+LT+F + EGW V+ DA R I++V ++ FF +N+
Sbjct: 1455 VLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNI 1514
Query: 1087 VLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEP 1266
+ ++ F ++ + K E+ LE++ + +D+ A+ +
Sbjct: 1515 FVALIIITFQEQGD---------KMMEEYSLEKNERACIDFAISAKPL------------ 1553
Query: 1267 VAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXX 1446
+ + + V S F +
Sbjct: 1554 -----------------------------TRHMPQNKQSFQYRMWQFVVSPPFEYTIMAM 1584
Query: 1447 XXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDC 1626
+ YG S D+ + N+ F LFS+E LLK+ + G Y +N FD
Sbjct: 1585 IALNTIVLMMKFYGASVAYDNALKVFNIVFTSLFSLECLLKVLAFGILNYFRDAWNIFDF 1644
Query: 1627 FVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXX 1806
V+ SI + ++ F + +S LR R R+ K+ +
Sbjct: 1645 VTVLGSITDILVTEFG-NNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPY 1703
Query: 1807 XXXXXXXXXXXXXXXGMQVFGG--------KFNFNPQQPKPRANFDTFVQALLTVFQILT 1962
GMQVFG + + Q NF TF QAL+ +F+ T
Sbjct: 1704 VCLLIAMLFFIYAIIGMQVFGNIGIDMEDEDSDEDEFQITEHNNFRTFFQALMLLFRSAT 1763
Query: 1963 GEDWNTVMYHGI-----ESFGGVGT--LGVIVCIYYIV--LFICGNYILLNVFLAIAVDN 2115
GE W+ +M + + G+ T G +Y V +F+C ++++LN+F+A+ +DN
Sbjct: 1764 GEAWHNIMLSCLSGKPCDKNSGILTPECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1822
Score = 120 bits (300), Expect = 5e-25
Identities = 73/274 (26%), Positives = 139/274 (50%), Gaps = 4/274 (1%)
Frame = +1
Query: 3313 RLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEA 3492
R+++ + V ++AF + + ++ +NT+ +A HY DFL IF G+F E
Sbjct: 475 RMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEM 534
Query: 3493 VLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVK 3672
+K+ L + Y +N FD V++GS ++ + + PG + I+ R R++R+ K
Sbjct: 535 FIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTS--FGISVLRALRLLRIFK 592
Query: 3673 LLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNN 3849
+ +R L+ + + S +++ + L+ L ++A++GMQ F G+ D+ T
Sbjct: 593 VTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTP---PT 649
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYP 4029
NF +FPAAI+ +F+ TGE W ++M + ++ +GG+ G
Sbjct: 650 NFDTFPAAIMTVFQILTGEDWNEVMY-----DGIK--------SQGGVQ----GGMVFSI 692
Query: 4030 YFISFFMLCSFLVINLFVAVIMDNF---DYLTRD 4122
YFI + ++ ++N+F+A+ +DN LT+D
Sbjct: 693 YFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 726
Score = 95.1 bits (235), Expect = 2e-17
Identities = 71/296 (23%), Positives = 129/296 (42%), Gaps = 13/296 (4%)
Frame = +1
Query: 265 PFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFM 444
PFE+ I+ MI N I L + + Y N L + VF +F++EC+LK++A G +
Sbjct: 1576 PFEYTIMAMIALNTIVLMM--KFYGASVAYDNAL-KVFNIVFTSLFSLECLLKVLAFGIL 1632
Query: 445 FHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQ 624
Y R+AWNI DF+ V+ + ++++ ++ LR FR R ++L+ +++
Sbjct: 1633 ----NYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIR 1688
Query: 625 VVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCG 804
++L +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1689 ILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF------------------------- 1723
Query: 805 TDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGW 984
N+G+ E + NF F A++ +F+ + E W
Sbjct: 1724 ----------------GNIGIDMEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAW 1767
Query: 985 TDVMYW-------------VNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
++M + G E+ + YFV+ + L SF +LNL + V+ F
Sbjct: 1768 HNIMLSCLSGKPCDKNSGILTPECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1823
Score = 85.5 bits (210), Expect = 1e-14
Identities = 69/263 (26%), Positives = 117/263 (44%), Gaps = 13/263 (4%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLF+ S N R + + F +L I+ + +LA E L + M L+
Sbjct: 77 SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSL-----TSFVLRTDAM 2667
+ +F +F E +K+I G FHKGS+ RN +N++D +VV + T F LRT
Sbjct: 137 EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRT--- 193
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
++ L+ V++ ++ A+ + I L+ F +FAIIG++ +
Sbjct: 194 -----LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFY 248
Query: 2848 KGTFFL------CNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAM 3009
G F +D+ + A C E + T+ +N FDN+ A+
Sbjct: 249 MGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTRCQPYWEGPNNGITQFDNILFAV 308
Query: 3010 ISLFVVSTFEGWPQLLYVAIDSN 3078
+++F T EGW LLY + D++
Sbjct: 309 LTVFQCITMEGWTDLLYNSNDAS 331
Score = 80.9 bits (198), Expect = 3e-13
Identities = 75/293 (25%), Positives = 123/293 (41%), Gaps = 43/293 (14%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY+I I+ N + LA + H P + LD F G+F FEA +KI+AL
Sbjct: 100 FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WNV D +VV+ G L GT + R RV+R +KL+S
Sbjct: 160 HKGSYLRNGWNVMDFVVVL-------TGILATVGTE-FDLRTLRAVRVLRPLKLVSGIPS 211
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQF----FGKVALDDSTSIHR------ 3843
++ +L + MK+ L + LL+ I+A+IG++F F ++ T +
Sbjct: 212 LQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAP 271
Query: 3844 -----------------------NN---NFHSFPAAILVLFRSATGEAWQDIMLSCSDRE 3945
NN F + A+L +F+ T E W D++ + +D
Sbjct: 272 CGTEEPARTCPNGTRCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDAS 331
Query: 3946 DVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
GN + + YFI ++ SF ++NL + V+ F
Sbjct: 332 ---------------------GNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 363
Score = 45.8 bits (107), Expect = 0.012
Identities = 50/264 (18%), Positives = 103/264 (38%), Gaps = 3/264 (1%)
Frame = +1
Query: 2293 AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN 2472
A +++K +S F R + +V F VL + +++ +A Q
Sbjct: 454 ARASIKSAKLENSSFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPE 513
Query: 2473 STRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL 2652
+ L Y ++ F +F E+ +K+ G + ++FN D V+ S+ +
Sbjct: 514 WLSDF-LYYAEFIFLGLFMSEMFIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIW 568
Query: 2653 RTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
K L+++V ++ ++K+I +++ + F+ +F
Sbjct: 569 AVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628
Query: 2824 AIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGD 3003
A++G+QLF G F ++++G P NFD
Sbjct: 629 ALLGMQLFGGQF-------------------NFDEGTPPT-------------NFDTFPA 656
Query: 3004 AMISLFVVSTFEGWPQLLYVAIDS 3075
A++++F + T E W +++Y I S
Sbjct: 657 AIMTVFQILTGEDWNEVMYDGIKS 680
>gi|6165988|sp|Q15878|CCAE_HUMAN Voltage-dependent R-type calcium
channel alpha-1E subunit (Voltage-gated calcium channel
alpha subunit Cav2.3) (Calcium channel, L type, alpha-1
polypeptide, isoform 6) (Brain calcium channel II) (BII)
gi|443761|gb|AAA72125.1| voltage-operated calcium channel, alpha-1
subunit
Length = 2312
Score = 663 bits (1710), Expect = 0.0
Identities = 353/774 (45%), Positives = 484/774 (61%), Gaps = 13/774 (1%)
Frame = +1
Query: 2302 TVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR 2481
T K + SS+FI S TN R C+ +VN YF +L I SS LAAEDP+ NS R
Sbjct: 1122 TGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSER 1181
Query: 2482 NMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTD 2661
N +L YFDY FT VFT E+ +K+I GL+ GS+ R+ +N+LD +VV +L +F L
Sbjct: 1182 NKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANA 1241
Query: 2662 A-------MSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFM 2820
+ I R LK V CV+ ++K + NI++V + F+
Sbjct: 1242 LGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFI 1301
Query: 2821 FAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVG 3000
FA+I VQLFKG FF C D SK TE EC G Y+ +E K K R W ++F++DN+
Sbjct: 1302 FAVIAVQLFKGKFFYCTDSSKDTEKECIGNYVDHEKN---KMEVKGREWKRHEFHYDNII 1358
Query: 3001 DAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXX 3180
A+++LF VST EGWPQ+L ++D EED+GP ++R +++
Sbjct: 1359 WALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFV 1418
Query: 3181 GFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRA 3354
+I+TFQ +G++ E C L+KN+R CI+FA+ AKP RY+P+NR QYRVW FV S +
Sbjct: 1419 ALIIITFQEQGDKMMEECSLEKNERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPS 1478
Query: 3355 FEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYIS 3534
FEY I +I +NTV L K+Y + +E L N+ FT VF+ E VLK++A NY
Sbjct: 1479 FEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFR 1538
Query: 3535 DRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWT 3714
D WN+FD + V+GS +I T+ +++F +LFR RL+KLL +G IR LLWT
Sbjct: 1539 DTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWT 1598
Query: 3715 FMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRS 3894
F++SF+ALPYV LLI +LFFIYA+IGMQ FG + LD+ + I+R+NNF SF ++++LFRS
Sbjct: 1599 FVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRS 1658
Query: 3895 ATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNES-RCGNNFAYPYFISFFMLCSFLVI 4071
ATGEAWQ+IMLSC + C+P D G NE+ RCG + AY YF+SF CSFL++
Sbjct: 1659 ATGEAWQEIMLSCLGEKG--CEP--DTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLML 1714
Query: 4072 NLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPL 4251
NLFVAVIMDNF+YLTRD SILGPHHL+EFVR+W+EYD A GRI + ++ +L +SPPL
Sbjct: 1715 NLFVAVIMDNFEYLTRDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPL 1774
Query: 4252 GFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKI-YTEGNID--EANEQL 4422
G GK CP ++A KRLV MNMP+ D TV F +TL AL+RT L I +G D + + +L
Sbjct: 1775 GLGKRCPSKVAYKRLVLMNMPVAEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSEL 1834
Query: 4423 RSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEME 4584
+ IW + +LD +V P K D+TVGK YA +I DY+++ K +K+ +
Sbjct: 1835 QKETLAIWPHLSQKMLDLLV-PMPKASDLTVGKIYAAMMIMDYYKQSKVKKQRQ 1887
Score = 514 bits (1323), Expect = e-143
Identities = 286/667 (42%), Positives = 373/667 (55%), Gaps = 27/667 (4%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N +RK +++W PFE++IL I ANCI LA+ Q P D + LE E FI +
Sbjct: 75 DNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGI 134
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KIVA+GF+FH +YLRN WN++DFI+V+ G+++T + + D++ LRA R
Sbjct: 135 FCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTH-VDLRTLRAVR 193
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQ+VL +I++AM+PLL I LL+ F IL++AIIGLE + GKLH C
Sbjct: 194 VLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFM 253
Query: 760 PATGQLAQKDPT-PCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNF 936
+G L DP PCG + ++C+ W GPN+GIT FDN
Sbjct: 254 NNSGILEGFDPPHPCGVQGCPAGYECKD------------------WIGPNDGITQFDNI 295
Query: 937 GLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFS 1116
A+LTVFQC+++EGWT V+Y NDA+G W W+YF+ L+I+GSFFVLNLVLGVLSGEF+
Sbjct: 296 LFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFA 355
Query: 1117 KEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNED---------------- 1248
KERE+ R F K R +QQ+E +L GY WI +AE++ E+
Sbjct: 356 KERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATI 415
Query: 1249 ----------EQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXX 1398
+ DE + +RL +++
Sbjct: 416 KRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRIS------I 469
Query: 1399 XXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYS 1578
+VKSQ FYW H+ Q +WL H A F+ LF +EM LKMY
Sbjct: 470 RHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYG 529
Query: 1579 LGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXX 1758
+G Y S FN FD V + SI E V F G+SVLR+ RLLRIFK+TKYW
Sbjct: 530 MGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASL 589
Query: 1759 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQAL 1938
GMQ+FGG+FNFN P ANFDTF A+
Sbjct: 590 RNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFN--DGTPSANFDTFPAAI 647
Query: 1939 LTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNL 2118
+TVFQILTGEDWN VMY+GI S GGV + G+ IY+IVL + GNY LLNVFLAIAVDNL
Sbjct: 648 ITVFQILTGEDWNEVMYNGIRSQGGVSS-GMWSAIYFIVLTLFGNYTLLNVFLAIAVDNL 706
Query: 2119 ADADSLT 2139
A+A LT
Sbjct: 707 ANAQELT 713
Score = 130 bits (327), Expect = 4e-28
Identities = 101/378 (26%), Positives = 172/378 (44%), Gaps = 14/378 (3%)
Frame = +1
Query: 139 KRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIALA 318
++ Q+K R+T NPIR+ C IV + FE IL +I A+ IALA
Sbjct: 1111 EKKKQKKEKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALA 1170
Query: 319 IYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFII 498
P +N +L +YVF VFT E V+K++ G + +Y R+ WNILDF++
Sbjct: 1171 AEDPVLTNSE--RNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVV 1228
Query: 499 VVIGLVSTILSKM--SIQGFD---VKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPL 663
VV LV+ L+ + +G D +K+LR RVLRPL+ + +P L+ V + ++ ++ +
Sbjct: 1229 VVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNV 1288
Query: 664 LHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPS 843
+I ++ + I+A+I ++LF GK C D + DTE
Sbjct: 1289 FNILIVYKLFMFIFAVIAVQLFKGKFF-YCTDSS-------------KDTEKECIGNYVD 1334
Query: 844 DSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAV-- 1017
M V+ W ++DN A+LT+F + EGW V+ D
Sbjct: 1335 HEKNKMEVK-----GREW---KRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEE 1386
Query: 1018 -------GREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQQ 1176
R I++V ++ FF +N+ + ++ F ++ + K E+
Sbjct: 1387 DRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGD---------KMMEECS 1437
Query: 1177 LEEDLKGYLDWITQAEDI 1230
LE++ + +D+ A+ +
Sbjct: 1438 LEKNERACIDFAISAKPL 1455
Score = 115 bits (289), Expect = 9e-24
Identities = 72/273 (26%), Positives = 137/273 (49%), Gaps = 4/273 (1%)
Frame = +1
Query: 3316 LQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAV 3495
L+ + V S+ F +++ ++ +NT +A H+ + L +F G+F E
Sbjct: 465 LRISIRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMS 524
Query: 3496 LKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKL 3675
LK+ + P+ Y +N FD V VGS ++ + PG + I+ R R++R+ K+
Sbjct: 525 LKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTS--FGISVLRALRLLRIFKI 582
Query: 3676 LSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNN 3852
+R L+ + M S +++ + L+ L ++A++GMQ F G+ +D T + N
Sbjct: 583 TKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTP---SAN 639
Query: 3853 FHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPY 4032
F +FPAAI+ +F+ TGE W ++M + +R +GG++ ++ Y
Sbjct: 640 FDTFPAAIITVFQILTGEDWNEVMYN-----GIR--------SQGGVSSGM----WSAIY 682
Query: 4033 FISFFMLCSFLVINLFVAVIMDNF---DYLTRD 4122
FI + ++ ++N+F+A+ +DN LT+D
Sbjct: 683 FIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 715
Score = 90.1 bits (222), Expect = 6e-16
Identities = 75/303 (24%), Positives = 133/303 (43%), Gaps = 21/303 (6%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+ I+ MI N + L + Y + Y+ L+ + F +VF++ECVLK++A GF+
Sbjct: 1479 FEYTIMAMIALNTVVLMM--KYYSAPCTYE-LALKYLNIAFTMVFSLECVLKVIAFGFL- 1534
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMSI---QGFDVKALRAFRVLRPLRLVSGVPS 618
Y R+ WNI DFI V+ + IL+ + GF++ L+ FR R ++L+ +
Sbjct: 1535 ---NYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYT 1591
Query: 619 LQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTP 798
++++L +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1592 IRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF----------------------- 1628
Query: 799 CGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLE 978
N+ + E N +N +F FG ML +F+ + E
Sbjct: 1629 ------------------GNIKLDEESHINR-----HNNFRSF--FGSLML-LFRSATGE 1662
Query: 979 GWTDVMYWV------------------NDAVGREWPWIYFVTLVILGSFFVLNLVLGVLS 1104
W ++M N+ G + ++YFV+ + SF +LNL + V+
Sbjct: 1663 AWQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIM 1722
Query: 1105 GEF 1113
F
Sbjct: 1723 DNF 1725
Score = 86.3 bits (212), Expect = 8e-15
Identities = 80/346 (23%), Positives = 152/346 (43%), Gaps = 9/346 (2%)
Frame = +1
Query: 232 RKLCISI---VEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
R L ISI V+ + F +++L ++ N +AI Q + LL E++F+ +F
Sbjct: 463 RLLRISIRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQ---WLTHLLYYAEFLFLGLF 519
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKALRAF 576
+E LK+ MG P Y +++N DF + V G + ++ + G F + LRA
Sbjct: 520 LLEMSLKMYGMG----PRLYFHSSFNCFDFGVTV-GSIFEVVWAIFRPGTSFGISVLRAL 574
Query: 577 RVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI 756
R+LR ++ SL+ ++ +++ +M ++ + L+ I+++A++G++LF G+ +
Sbjct: 575 RLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFN-- 632
Query: 757 DPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNF 936
D TP NFD F
Sbjct: 633 ----------DGTPSA---------------------------------------NFDTF 643
Query: 937 GLAMLTVFQCVSLEGWTDVMYWVNDAVG----REWPWIYFVTLVILGSFFVLNLVLGVLS 1104
A++TVFQ ++ E W +VMY + G W IYF+ L + G++ +LN+ L +
Sbjct: 644 PAAIITVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAIYFIVLTLFGNYTLLNVFLAIAV 703
Query: 1105 GEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVN 1242
+ Q+ + +Q EE+ + +A+++ P++
Sbjct: 704 DNLANA----------QELTKDEQEEEEAFNQKHALQKAKEVSPMS 739
Score = 79.0 bits (193), Expect = 1e-12
Identities = 104/484 (21%), Positives = 184/484 (37%), Gaps = 46/484 (9%)
Frame = +1
Query: 1534 FVILFSMEMLLKMYSLGFTTYTTSQF----NRFDCFVVISSILEFVLVY-FDLMKPLGVS 1698
F +F+ EM++KM G S F N D VV+ +++ F L K +
Sbjct: 1192 FTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIK 1251
Query: 1699 VLRSARLLRIF---KVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFG 1869
++S R+LR+ K K +Q+F
Sbjct: 1252 TIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFK 1311
Query: 1870 GKFNF---------------------NPQQPKPRA------NFDTFVQALLTVFQILTGE 1968
GKF + N + K R ++D + ALLT+F + TGE
Sbjct: 1312 GKFFYCTDSSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGE 1371
Query: 1969 DWNTVMYHGI----ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLAD-ADS 2133
W V+ H + E G + + + I+Y+V F+ + +N+F+A+ + + D
Sbjct: 1372 GWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDK 1431
Query: 2134 LTNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSARPRRMSEVPAASTVKP 2313
+ S + + A + KP
Sbjct: 1432 MMEE-------------------------------------CSLEKNERACIDFAISAKP 1454
Query: 2314 IPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMIL 2493
+ + HT +RV+ + VV+ S F ++ I +++ +L + A T + L
Sbjct: 1455 LTRYMPQ--NRHTFQYRVW-HFVVSPS-FEYTIMAMIALNTVVLMMK-YYSAPCTYELAL 1509
Query: 2494 NYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSX 2673
Y + FT VF++E LKVI FG + ++ R+ +N+ D + V S+T +L TD+
Sbjct: 1510 KYLNIAFTMVFSLECVLKVIAFGFL----NYFRDTWNIFDFITVIGSITEIIL-TDSKLV 1564
Query: 2674 XXXXXXXXXXXXXXAINRAKGLKH------VVQCVIVAVKTIGNIMLVTFMLQFMFAIIG 2835
A K L+ ++ + + K + + L+ ML F++AIIG
Sbjct: 1565 NTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIG 1624
Query: 2836 VQLF 2847
+Q+F
Sbjct: 1625 MQVF 1628
Score = 79.0 bits (193), Expect = 1e-12
Identities = 68/267 (25%), Positives = 114/267 (42%), Gaps = 18/267 (6%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLFI N R + +++ F +L I+ + +LA E L + M L
Sbjct: 68 SLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT 127
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV-----AVSLTSFVLRTDAM 2667
+ +F +F E +K++ G +FHKGS+ RN +N++D +VV A + T F D
Sbjct: 128 EPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLR 187
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
+ ++ L+ V++ ++ A+ + I L+ F MFAIIG++ +
Sbjct: 188 T----LRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY 243
Query: 2848 KGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVS----------KKRVWSNNDF-NFDN 2994
G K+ A E DP P K + N+ FDN
Sbjct: 244 SG---------KLHRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDN 294
Query: 2995 VGDAMISLFVVSTFEGWPQLLYVAIDS 3075
+ A++++F T EGW +LY D+
Sbjct: 295 ILFAVLTVFQCITMEGWTTVLYNTNDA 321
Score = 77.8 bits (190), Expect = 3e-12
Identities = 117/586 (19%), Positives = 203/586 (33%), Gaps = 71/586 (12%)
Frame = +1
Query: 1531 FFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVS 1698
+F+ +F E +K+ +LGF +Y + +N D VV+S IL +F+ L
Sbjct: 130 YFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDL--R 187
Query: 1699 VLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF 1878
LR+ R+LR K+ G++ + GK
Sbjct: 188 TLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKL 247
Query: 1879 N-------------FNPQQP-------------------KPRANFDTFVQALLTVFQILT 1962
+ F+P P FD + A+LTVFQ +T
Sbjct: 248 HRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCIT 307
Query: 1963 GEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLA------- 2121
E W TV+Y+ ++ G +Y+I L I G++ +LN+ L + A
Sbjct: 308 MEGWTTVLYNTNDALGATWNW-----LYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVE 362
Query: 2122 ------------DADSLTNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSA 2265
+ N T A
Sbjct: 363 NRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEA 422
Query: 2266 RPRRMSE---VPAASTVKPIPKASSL--------FILSHTNSFRVFCNMVVNHSYFTNAV 2412
R S+ V +S P+ +AS + R+ +V F V
Sbjct: 423 MTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYWIV 482
Query: 2413 LFCILVSSAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFG--LVFHKGSF 2586
L + +++A +A Q ++ L Y ++ F +F +E++LK+ G L FH
Sbjct: 483 LSLVALNTACVAIVHHNQPQWLTHL-LYYAEFLFLGLFLLEMSLKMYGMGPRLYFH---- 537
Query: 2587 CRNAFNLLDILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQC 2757
++FN D V S+ V K L+++V
Sbjct: 538 --SSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVS 595
Query: 2758 VIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDP 2937
++ ++K+I +++ + F+ +FA++G+QLF G F ++ DG P
Sbjct: 596 LMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF-------------------NFNDGTP 636
Query: 2938 TKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
+ NFD A+I++F + T E W +++Y I S
Sbjct: 637 SA-------------NFDTFPAAIITVFQILTGEDWNEVMYNGIRS 669
Score = 77.8 bits (190), Expect = 3e-12
Identities = 75/303 (24%), Positives = 124/303 (40%), Gaps = 53/303 (17%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACKHY-------PSSRGFEDFLDVFNLIFTGVFAFEAVLKIVAL 3513
FEY+I I+ N + LA + + P SR E F G+F FEA +KIVAL
Sbjct: 91 FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT----EPYFIGIFCFEAGIKIVAL 146
Query: 3514 ----NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNL---ISINFFRLFRVMRLVK 3672
+ +Y+ + WNV D +VV+ G L GT+ + + R RV+R +K
Sbjct: 147 GFIFHKGSYLRNGWNVMDFIVVLS-------GILATAGTHFNTHVDLRTLRAVRVLRPLK 199
Query: 3673 LLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHR--- 3843
L+S ++ +L + MK+ L + LL+ ++A+IG++F+ S +HR
Sbjct: 200 LVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY-------SGKLHRACF 252
Query: 3844 -NNN-----------------------------------FHSFPAAILVLFRSATGEAWQ 3915
NN+ F + A+L +F+ T E W
Sbjct: 253 MNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWT 312
Query: 3916 DIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIM 4095
++ + +D G + + YFI ++ SF V+NL + V+
Sbjct: 313 TVLYNTND---------------------ALGATWNWLYFIPLIIIGSFFVLNLVLGVLS 351
Query: 4096 DNF 4104
F
Sbjct: 352 GEF 354
Score = 66.2 bits (160), Expect = 9e-09
Identities = 52/214 (24%), Positives = 86/214 (39%), Gaps = 17/214 (7%)
Frame = +1
Query: 1525 NLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLG--VS 1698
N+ F ++FS+E +LK+ + GF Y +N FD VI SI E +L L+ G +S
Sbjct: 1513 NIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMS 1572
Query: 1699 VLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF 1878
L+ R R+ K+ + GMQVFG
Sbjct: 1573 FLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIK 1632
Query: 1879 NFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFG---------------G 2013
NF +F +L+ +F+ TGE W +M + G
Sbjct: 1633 LDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQNENER 1692
Query: 2014 VGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDN 2115
GT + +Y++ ++++LN+F+A+ +DN
Sbjct: 1693 CGT--DLAYVYFVSFIFFCSFLMLNLFVAVIMDN 1724
>gi|4502529|ref|NP_000712.1| calcium channel, voltage-dependent, alpha
1E subunit [Homo sapiens]
gi|1082918|pir||B54972 voltage-dependent calcium channel alpha 1E-1 -
human
gi|495868|gb|AAA59204.1| voltage-dependent calcium channel alpha-1E-1
Length = 2251
Score = 663 bits (1710), Expect = 0.0
Identities = 353/774 (45%), Positives = 484/774 (61%), Gaps = 13/774 (1%)
Frame = +1
Query: 2302 TVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR 2481
T K + SS+FI S TN R C+ +VN YF +L I SS LAAEDP+ NS R
Sbjct: 1104 TGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSER 1163
Query: 2482 NMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTD 2661
N +L YFDY FT VFT E+ +K+I GL+ GS+ R+ +N+LD +VV +L +F L
Sbjct: 1164 NKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANA 1223
Query: 2662 A-------MSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFM 2820
+ I R LK V CV+ ++K + NI++V + F+
Sbjct: 1224 LGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFI 1283
Query: 2821 FAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVG 3000
FA+I VQLFKG FF C D SK TE EC G Y+ +E K K R W ++F++DN+
Sbjct: 1284 FAVIAVQLFKGKFFYCTDSSKDTEKECIGNYVDHEKN---KMEVKGREWKRHEFHYDNII 1340
Query: 3001 DAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXX 3180
A+++LF VST EGWPQ+L ++D EED+GP ++R +++
Sbjct: 1341 WALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFV 1400
Query: 3181 GFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRA 3354
+I+TFQ +G++ E C L+KN+R CI+FA+ AKP RY+P+NR QYRVW FV S +
Sbjct: 1401 ALIIITFQEQGDKMMEECSLEKNERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPS 1460
Query: 3355 FEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYIS 3534
FEY I +I +NTV L K+Y + +E L N+ FT VF+ E VLK++A NY
Sbjct: 1461 FEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFR 1520
Query: 3535 DRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWT 3714
D WN+FD + V+GS +I T+ +++F +LFR RL+KLL +G IR LLWT
Sbjct: 1521 DTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWT 1580
Query: 3715 FMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRS 3894
F++SF+ALPYV LLI +LFFIYA+IGMQ FG + LD+ + I+R+NNF SF ++++LFRS
Sbjct: 1581 FVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRS 1640
Query: 3895 ATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNES-RCGNNFAYPYFISFFMLCSFLVI 4071
ATGEAWQ+IMLSC + C+P D G NE+ RCG + AY YF+SF CSFL++
Sbjct: 1641 ATGEAWQEIMLSCLGEKG--CEP--DTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLML 1696
Query: 4072 NLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPL 4251
NLFVAVIMDNF+YLTRD SILGPHHL+EFVR+W+EYD A GRI + ++ +L +SPPL
Sbjct: 1697 NLFVAVIMDNFEYLTRDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPL 1756
Query: 4252 GFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKI-YTEGNID--EANEQL 4422
G GK CP ++A KRLV MNMP+ D TV F +TL AL+RT L I +G D + + +L
Sbjct: 1757 GLGKRCPSKVAYKRLVLMNMPVAEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSEL 1816
Query: 4423 RSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEME 4584
+ IW + +LD +V P K D+TVGK YA +I DY+++ K +K+ +
Sbjct: 1817 QKETLAIWPHLSQKMLDLLV-PMPKASDLTVGKIYAAMMIMDYYKQSKVKKQRQ 1869
Score = 514 bits (1323), Expect = e-143
Identities = 286/667 (42%), Positives = 373/667 (55%), Gaps = 27/667 (4%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N +RK +++W PFE++IL I ANCI LA+ Q P D + LE E FI +
Sbjct: 75 DNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGI 134
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KIVA+GF+FH +YLRN WN++DFI+V+ G+++T + + D++ LRA R
Sbjct: 135 FCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTH-VDLRTLRAVR 193
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQ+VL +I++AM+PLL I LL+ F IL++AIIGLE + GKLH C
Sbjct: 194 VLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFM 253
Query: 760 PATGQLAQKDPT-PCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNF 936
+G L DP PCG + ++C+ W GPN+GIT FDN
Sbjct: 254 NNSGILEGFDPPHPCGVQGCPAGYECKD------------------WIGPNDGITQFDNI 295
Query: 937 GLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFS 1116
A+LTVFQC+++EGWT V+Y NDA+G W W+YF+ L+I+GSFFVLNLVLGVLSGEF+
Sbjct: 296 LFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFA 355
Query: 1117 KEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNED---------------- 1248
KERE+ R F K R +QQ+E +L GY WI +AE++ E+
Sbjct: 356 KERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATI 415
Query: 1249 ----------EQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXX 1398
+ DE + +RL +++
Sbjct: 416 KRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRIS------I 469
Query: 1399 XXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYS 1578
+VKSQ FYW H+ Q +WL H A F+ LF +EM LKMY
Sbjct: 470 RHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYG 529
Query: 1579 LGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXX 1758
+G Y S FN FD V + SI E V F G+SVLR+ RLLRIFK+TKYW
Sbjct: 530 MGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASL 589
Query: 1759 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQAL 1938
GMQ+FGG+FNFN P ANFDTF A+
Sbjct: 590 RNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFN--DGTPSANFDTFPAAI 647
Query: 1939 LTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNL 2118
+TVFQILTGEDWN VMY+GI S GGV + G+ IY+IVL + GNY LLNVFLAIAVDNL
Sbjct: 648 MTVFQILTGEDWNEVMYNGIRSQGGVSS-GMWSAIYFIVLTLFGNYTLLNVFLAIAVDNL 706
Query: 2119 ADADSLT 2139
A+A LT
Sbjct: 707 ANAQELT 713
Score = 130 bits (327), Expect = 4e-28
Identities = 101/378 (26%), Positives = 172/378 (44%), Gaps = 14/378 (3%)
Frame = +1
Query: 139 KRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIALA 318
++ Q+K R+T NPIR+ C IV + FE IL +I A+ IALA
Sbjct: 1093 EKKKQKKEKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALA 1152
Query: 319 IYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFII 498
P +N +L +YVF VFT E V+K++ G + +Y R+ WNILDF++
Sbjct: 1153 AEDPVLTNSE--RNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVV 1210
Query: 499 VVIGLVSTILSKM--SIQGFD---VKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPL 663
VV LV+ L+ + +G D +K+LR RVLRPL+ + +P L+ V + ++ ++ +
Sbjct: 1211 VVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNV 1270
Query: 664 LHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPS 843
+I ++ + I+A+I ++LF GK C D + DTE
Sbjct: 1271 FNILIVYKLFMFIFAVIAVQLFKGKFF-YCTDSS-------------KDTEKECIGNYVD 1316
Query: 844 DSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAV-- 1017
M V+ W ++DN A+LT+F + EGW V+ D
Sbjct: 1317 HEKNKMEVK-----GREW---KRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEE 1368
Query: 1018 -------GREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQQ 1176
R I++V ++ FF +N+ + ++ F ++ + K E+
Sbjct: 1369 DRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGD---------KMMEECS 1419
Query: 1177 LEEDLKGYLDWITQAEDI 1230
LE++ + +D+ A+ +
Sbjct: 1420 LEKNERACIDFAISAKPL 1437
Score = 115 bits (289), Expect = 9e-24
Identities = 72/273 (26%), Positives = 137/273 (49%), Gaps = 4/273 (1%)
Frame = +1
Query: 3316 LQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAV 3495
L+ + V S+ F +++ ++ +NT +A H+ + L +F G+F E
Sbjct: 465 LRISIRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMS 524
Query: 3496 LKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKL 3675
LK+ + P+ Y +N FD V VGS ++ + PG + I+ R R++R+ K+
Sbjct: 525 LKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTS--FGISVLRALRLLRIFKI 582
Query: 3676 LSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNN 3852
+R L+ + M S +++ + L+ L ++A++GMQ F G+ +D T + N
Sbjct: 583 TKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTP---SAN 639
Query: 3853 FHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPY 4032
F +FPAAI+ +F+ TGE W ++M + +R +GG++ ++ Y
Sbjct: 640 FDTFPAAIMTVFQILTGEDWNEVMYN-----GIR--------SQGGVSSGM----WSAIY 682
Query: 4033 FISFFMLCSFLVINLFVAVIMDNF---DYLTRD 4122
FI + ++ ++N+F+A+ +DN LT+D
Sbjct: 683 FIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 715
Score = 90.1 bits (222), Expect = 6e-16
Identities = 75/303 (24%), Positives = 133/303 (43%), Gaps = 21/303 (6%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+ I+ MI N + L + Y + Y+ L+ + F +VF++ECVLK++A GF+
Sbjct: 1461 FEYTIMAMIALNTVVLMM--KYYSAPCTYE-LALKYLNIAFTMVFSLECVLKVIAFGFL- 1516
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMSI---QGFDVKALRAFRVLRPLRLVSGVPS 618
Y R+ WNI DFI V+ + IL+ + GF++ L+ FR R ++L+ +
Sbjct: 1517 ---NYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYT 1573
Query: 619 LQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTP 798
++++L +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1574 IRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF----------------------- 1610
Query: 799 CGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLE 978
N+ + E N +N +F FG ML +F+ + E
Sbjct: 1611 ------------------GNIKLDEESHINR-----HNNFRSF--FGSLML-LFRSATGE 1644
Query: 979 GWTDVMYWV------------------NDAVGREWPWIYFVTLVILGSFFVLNLVLGVLS 1104
W ++M N+ G + ++YFV+ + SF +LNL + V+
Sbjct: 1645 AWQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIM 1704
Query: 1105 GEF 1113
F
Sbjct: 1705 DNF 1707
Score = 86.3 bits (212), Expect = 8e-15
Identities = 80/346 (23%), Positives = 152/346 (43%), Gaps = 9/346 (2%)
Frame = +1
Query: 232 RKLCISI---VEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
R L ISI V+ + F +++L ++ N +AI Q + LL E++F+ +F
Sbjct: 463 RLLRISIRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQ---WLTHLLYYAEFLFLGLF 519
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKALRAF 576
+E LK+ MG P Y +++N DF + V G + ++ + G F + LRA
Sbjct: 520 LLEMSLKMYGMG----PRLYFHSSFNCFDFGVTV-GSIFEVVWAIFRPGTSFGISVLRAL 574
Query: 577 RVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI 756
R+LR ++ SL+ ++ +++ +M ++ + L+ I+++A++G++LF G+ +
Sbjct: 575 RLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFN-- 632
Query: 757 DPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNF 936
D TP NFD F
Sbjct: 633 ----------DGTPSA---------------------------------------NFDTF 643
Query: 937 GLAMLTVFQCVSLEGWTDVMYWVNDAVG----REWPWIYFVTLVILGSFFVLNLVLGVLS 1104
A++TVFQ ++ E W +VMY + G W IYF+ L + G++ +LN+ L +
Sbjct: 644 PAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAIYFIVLTLFGNYTLLNVFLAIAV 703
Query: 1105 GEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVN 1242
+ Q+ + +Q EE+ + +A+++ P++
Sbjct: 704 DNLANA----------QELTKDEQEEEEAFNQKHALQKAKEVSPMS 739
Score = 79.0 bits (193), Expect = 1e-12
Identities = 104/484 (21%), Positives = 184/484 (37%), Gaps = 46/484 (9%)
Frame = +1
Query: 1534 FVILFSMEMLLKMYSLGFTTYTTSQF----NRFDCFVVISSILEFVLVY-FDLMKPLGVS 1698
F +F+ EM++KM G S F N D VV+ +++ F L K +
Sbjct: 1174 FTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIK 1233
Query: 1699 VLRSARLLRIF---KVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFG 1869
++S R+LR+ K K +Q+F
Sbjct: 1234 TIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFK 1293
Query: 1870 GKFNF---------------------NPQQPKPRA------NFDTFVQALLTVFQILTGE 1968
GKF + N + K R ++D + ALLT+F + TGE
Sbjct: 1294 GKFFYCTDSSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGE 1353
Query: 1969 DWNTVMYHGI----ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLAD-ADS 2133
W V+ H + E G + + + I+Y+V F+ + +N+F+A+ + + D
Sbjct: 1354 GWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDK 1413
Query: 2134 LTNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSARPRRMSEVPAASTVKP 2313
+ S + + A + KP
Sbjct: 1414 MMEE-------------------------------------CSLEKNERACIDFAISAKP 1436
Query: 2314 IPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMIL 2493
+ + HT +RV+ + VV+ S F ++ I +++ +L + A T + L
Sbjct: 1437 LTRYMPQ--NRHTFQYRVW-HFVVSPS-FEYTIMAMIALNTVVLMMK-YYSAPCTYELAL 1491
Query: 2494 NYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSX 2673
Y + FT VF++E LKVI FG + ++ R+ +N+ D + V S+T +L TD+
Sbjct: 1492 KYLNIAFTMVFSLECVLKVIAFGFL----NYFRDTWNIFDFITVIGSITEIIL-TDSKLV 1546
Query: 2674 XXXXXXXXXXXXXXAINRAKGLKH------VVQCVIVAVKTIGNIMLVTFMLQFMFAIIG 2835
A K L+ ++ + + K + + L+ ML F++AIIG
Sbjct: 1547 NTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIG 1606
Query: 2836 VQLF 2847
+Q+F
Sbjct: 1607 MQVF 1610
Score = 79.0 bits (193), Expect = 1e-12
Identities = 68/267 (25%), Positives = 114/267 (42%), Gaps = 18/267 (6%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLFI N R + +++ F +L I+ + +LA E L + M L
Sbjct: 68 SLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT 127
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV-----AVSLTSFVLRTDAM 2667
+ +F +F E +K++ G +FHKGS+ RN +N++D +VV A + T F D
Sbjct: 128 EPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLR 187
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
+ ++ L+ V++ ++ A+ + I L+ F MFAIIG++ +
Sbjct: 188 T----LRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY 243
Query: 2848 KGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVS----------KKRVWSNNDF-NFDN 2994
G K+ A E DP P K + N+ FDN
Sbjct: 244 SG---------KLHRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDN 294
Query: 2995 VGDAMISLFVVSTFEGWPQLLYVAIDS 3075
+ A++++F T EGW +LY D+
Sbjct: 295 ILFAVLTVFQCITMEGWTTVLYNTNDA 321
Score = 77.8 bits (190), Expect = 3e-12
Identities = 75/303 (24%), Positives = 124/303 (40%), Gaps = 53/303 (17%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACKHY-------PSSRGFEDFLDVFNLIFTGVFAFEAVLKIVAL 3513
FEY+I I+ N + LA + + P SR E F G+F FEA +KIVAL
Sbjct: 91 FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT----EPYFIGIFCFEAGIKIVAL 146
Query: 3514 ----NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNL---ISINFFRLFRVMRLVK 3672
+ +Y+ + WNV D +VV+ G L GT+ + + R RV+R +K
Sbjct: 147 GFIFHKGSYLRNGWNVMDFIVVLS-------GILATAGTHFNTHVDLRTLRAVRVLRPLK 199
Query: 3673 LLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHR--- 3843
L+S ++ +L + MK+ L + LL+ ++A+IG++F+ S +HR
Sbjct: 200 LVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY-------SGKLHRACF 252
Query: 3844 -NNN-----------------------------------FHSFPAAILVLFRSATGEAWQ 3915
NN+ F + A+L +F+ T E W
Sbjct: 253 MNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWT 312
Query: 3916 DIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIM 4095
++ + +D G + + YFI ++ SF V+NL + V+
Sbjct: 313 TVLYNTND---------------------ALGATWNWLYFIPLIIIGSFFVLNLVLGVLS 351
Query: 4096 DNF 4104
F
Sbjct: 352 GEF 354
Score = 76.6 bits (187), Expect = 6e-12
Identities = 116/586 (19%), Positives = 203/586 (33%), Gaps = 71/586 (12%)
Frame = +1
Query: 1531 FFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVS 1698
+F+ +F E +K+ +LGF +Y + +N D VV+S IL +F+ L
Sbjct: 130 YFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDL--R 187
Query: 1699 VLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF 1878
LR+ R+LR K+ G++ + GK
Sbjct: 188 TLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKL 247
Query: 1879 N-------------FNPQQP-------------------KPRANFDTFVQALLTVFQILT 1962
+ F+P P FD + A+LTVFQ +T
Sbjct: 248 HRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCIT 307
Query: 1963 GEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLA------- 2121
E W TV+Y+ ++ G +Y+I L I G++ +LN+ L + A
Sbjct: 308 MEGWTTVLYNTNDALGATWNW-----LYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVE 362
Query: 2122 ------------DADSLTNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSA 2265
+ N T A
Sbjct: 363 NRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEA 422
Query: 2266 RPRRMSE---VPAASTVKPIPKASSL--------FILSHTNSFRVFCNMVVNHSYFTNAV 2412
R S+ V +S P+ +AS + R+ +V F V
Sbjct: 423 MTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYWIV 482
Query: 2413 LFCILVSSAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFG--LVFHKGSF 2586
L + +++A +A Q ++ L Y ++ F +F +E++LK+ G L FH
Sbjct: 483 LSLVALNTACVAIVHHNQPQWLTHL-LYYAEFLFLGLFLLEMSLKMYGMGPRLYFH---- 537
Query: 2587 CRNAFNLLDILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQC 2757
++FN D V S+ V K L+++V
Sbjct: 538 --SSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVS 595
Query: 2758 VIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDP 2937
++ ++K+I +++ + F+ +FA++G+QLF G F ++ DG P
Sbjct: 596 LMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF-------------------NFNDGTP 636
Query: 2938 TKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
+ NFD A++++F + T E W +++Y I S
Sbjct: 637 SA-------------NFDTFPAAIMTVFQILTGEDWNEVMYNGIRS 669
Score = 66.2 bits (160), Expect = 9e-09
Identities = 52/214 (24%), Positives = 86/214 (39%), Gaps = 17/214 (7%)
Frame = +1
Query: 1525 NLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLG--VS 1698
N+ F ++FS+E +LK+ + GF Y +N FD VI SI E +L L+ G +S
Sbjct: 1495 NIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMS 1554
Query: 1699 VLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF 1878
L+ R R+ K+ + GMQVFG
Sbjct: 1555 FLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIK 1614
Query: 1879 NFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFG---------------G 2013
NF +F +L+ +F+ TGE W +M + G
Sbjct: 1615 LDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQNENER 1674
Query: 2014 VGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDN 2115
GT + +Y++ ++++LN+F+A+ +DN
Sbjct: 1675 CGT--DLAYVYFVSFIFFCSFLMLNLFVAVIMDN 1706
>gi|7159257|gb|AAF37687.1| calcium channel alpha1E subunit, delta39
splice variant [Homo sapiens]
Length = 2224
Score = 663 bits (1710), Expect = 0.0
Identities = 353/774 (45%), Positives = 484/774 (61%), Gaps = 13/774 (1%)
Frame = +1
Query: 2302 TVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR 2481
T K + SS+FI S TN R C+ +VN YF +L I SS LAAEDP+ NS R
Sbjct: 1034 TGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSER 1093
Query: 2482 NMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTD 2661
N +L YFDY FT VFT E+ +K+I GL+ GS+ R+ +N+LD +VV +L +F L
Sbjct: 1094 NKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANA 1153
Query: 2662 A-------MSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFM 2820
+ I R LK V CV+ ++K + NI++V + F+
Sbjct: 1154 LGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFI 1213
Query: 2821 FAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVG 3000
FA+I VQLFKG FF C D SK TE EC G Y+ +E K K R W ++F++DN+
Sbjct: 1214 FAVIAVQLFKGKFFYCTDSSKDTEKECIGNYVDHEKN---KMEVKGREWKRHEFHYDNII 1270
Query: 3001 DAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXX 3180
A+++LF VST EGWPQ+L ++D EED+GP ++R +++
Sbjct: 1271 WALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFV 1330
Query: 3181 GFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRA 3354
+I+TFQ +G++ E C L+KN+R CI+FA+ AKP RY+P+NR QYRVW FV S +
Sbjct: 1331 ALIIITFQEQGDKMMEECSLEKNERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPS 1390
Query: 3355 FEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYIS 3534
FEY I +I +NTV L K+Y + +E L N+ FT VF+ E VLK++A NY
Sbjct: 1391 FEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFR 1450
Query: 3535 DRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWT 3714
D WN+FD + V+GS +I T+ +++F +LFR RL+KLL +G IR LLWT
Sbjct: 1451 DTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWT 1510
Query: 3715 FMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRS 3894
F++SF+ALPYV LLI +LFFIYA+IGMQ FG + LD+ + I+R+NNF SF ++++LFRS
Sbjct: 1511 FVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRS 1570
Query: 3895 ATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNES-RCGNNFAYPYFISFFMLCSFLVI 4071
ATGEAWQ+IMLSC + C+P D G NE+ RCG + AY YF+SF CSFL++
Sbjct: 1571 ATGEAWQEIMLSCLGEKG--CEP--DTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLML 1626
Query: 4072 NLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPL 4251
NLFVAVIMDNF+YLTRD SILGPHHL+EFVR+W+EYD A GRI + ++ +L +SPPL
Sbjct: 1627 NLFVAVIMDNFEYLTRDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPL 1686
Query: 4252 GFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKI-YTEGNID--EANEQL 4422
G GK CP ++A KRLV MNMP+ D TV F +TL AL+RT L I +G D + + +L
Sbjct: 1687 GLGKRCPSKVAYKRLVLMNMPVAEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSEL 1746
Query: 4423 RSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEME 4584
+ IW + +LD +V P K D+TVGK YA +I DY+++ K +K+ +
Sbjct: 1747 QKETLAIWPHLSQKMLDLLV-PMPKASDLTVGKIYAAMMIMDYYKQSKVKKQRQ 1799
Score = 502 bits (1293), Expect = e-140
Identities = 282/652 (43%), Positives = 364/652 (55%), Gaps = 27/652 (4%)
Frame = +1
Query: 265 PFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFM 444
PFE++IL I ANCI LA+ Q P D + LE E FI +F E +KIVA+GF+
Sbjct: 1 PFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFI 60
Query: 445 FHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQ 624
FH +YLRN WN++DFI+V+ G+++T + + D++ LRA RVLRPL+LVSG+PSLQ
Sbjct: 61 FHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTH-VDLRTLRAVRVLRPLKLVSGIPSLQ 119
Query: 625 VVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPT-PC 801
+VL +I++AM+PLL I LL+ F IL++AIIGLE + GKLH C +G L DP PC
Sbjct: 120 IVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPC 179
Query: 802 GTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEG 981
G + ++C+ W GPN+GIT FDN A+LTVFQC+++EG
Sbjct: 180 GVQGCPAGYECKD------------------WIGPNDGITQFDNILFAVLTVFQCITMEG 221
Query: 982 WTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKF 1161
WT V+Y NDA+G W W+YF+ L+I+GSFFVLNLVLGVLSGEF+KERE+ R F K
Sbjct: 222 WTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMKL 281
Query: 1162 REKQQLEEDLKGYLDWITQAEDIEPVNED--------------------------EQEDE 1263
R +QQ+E +L GY WI +AE++ E+ + DE
Sbjct: 282 RRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEAMTRDSSDE 341
Query: 1264 PVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXX 1443
+ +RL +++ +VKSQ FYW
Sbjct: 342 HCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRIS------IRHMVKSQVFYWIVLS 395
Query: 1444 XXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFD 1623
H+ Q +WL H A F+ LF +EM LKMY +G Y S FN FD
Sbjct: 396 LVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFD 455
Query: 1624 CFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXX 1803
V + SI E V F G+SVLR+ RLLRIFK+TKYW
Sbjct: 456 FGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSII 515
Query: 1804 XXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTV 1983
GMQ+FGG+FNFN P ANFDTF A++TVFQILTGEDWN V
Sbjct: 516 SLLFLLFLFIVVFALLGMQLFGGRFNFN--DGTPSANFDTFPAAIMTVFQILTGEDWNEV 573
Query: 1984 MYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLT 2139
MY+GI S GGV + G+ IY+IVL + GNY LLNVFLAIAVDNLA+A LT
Sbjct: 574 MYNGIRSQGGVSS-GMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELT 624
Score = 130 bits (327), Expect = 4e-28
Identities = 101/378 (26%), Positives = 172/378 (44%), Gaps = 14/378 (3%)
Frame = +1
Query: 139 KRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIALA 318
++ Q+K R+T NPIR+ C IV + FE IL +I A+ IALA
Sbjct: 1023 EKKKQKKEKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALA 1082
Query: 319 IYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFII 498
P +N +L +YVF VFT E V+K++ G + +Y R+ WNILDF++
Sbjct: 1083 AEDPVLTNSE--RNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVV 1140
Query: 499 VVIGLVSTILSKM--SIQGFD---VKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPL 663
VV LV+ L+ + +G D +K+LR RVLRPL+ + +P L+ V + ++ ++ +
Sbjct: 1141 VVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNV 1200
Query: 664 LHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPS 843
+I ++ + I+A+I ++LF GK C D + DTE
Sbjct: 1201 FNILIVYKLFMFIFAVIAVQLFKGKFF-YCTDSS-------------KDTEKECIGNYVD 1246
Query: 844 DSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAV-- 1017
M V+ W ++DN A+LT+F + EGW V+ D
Sbjct: 1247 HEKNKMEVK-----GREW---KRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEE 1298
Query: 1018 -------GREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQQ 1176
R I++V ++ FF +N+ + ++ F ++ + K E+
Sbjct: 1299 DRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGD---------KMMEECS 1349
Query: 1177 LEEDLKGYLDWITQAEDI 1230
LE++ + +D+ A+ +
Sbjct: 1350 LEKNERACIDFAISAKPL 1367
Score = 115 bits (289), Expect = 9e-24
Identities = 72/273 (26%), Positives = 137/273 (49%), Gaps = 4/273 (1%)
Frame = +1
Query: 3316 LQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAV 3495
L+ + V S+ F +++ ++ +NT +A H+ + L +F G+F E
Sbjct: 376 LRISIRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMS 435
Query: 3496 LKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKL 3675
LK+ + P+ Y +N FD V VGS ++ + PG + I+ R R++R+ K+
Sbjct: 436 LKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTS--FGISVLRALRLLRIFKI 493
Query: 3676 LSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNN 3852
+R L+ + M S +++ + L+ L ++A++GMQ F G+ +D T + N
Sbjct: 494 TKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTP---SAN 550
Query: 3853 FHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPY 4032
F +FPAAI+ +F+ TGE W ++M + +R +GG++ ++ Y
Sbjct: 551 FDTFPAAIMTVFQILTGEDWNEVMYN-----GIR--------SQGGVSSGM----WSAIY 593
Query: 4033 FISFFMLCSFLVINLFVAVIMDNF---DYLTRD 4122
FI + ++ ++N+F+A+ +DN LT+D
Sbjct: 594 FIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 626
Score = 90.1 bits (222), Expect = 6e-16
Identities = 75/303 (24%), Positives = 133/303 (43%), Gaps = 21/303 (6%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+ I+ MI N + L + Y + Y+ L+ + F +VF++ECVLK++A GF+
Sbjct: 1391 FEYTIMAMIALNTVVLMM--KYYSAPCTYE-LALKYLNIAFTMVFSLECVLKVIAFGFL- 1446
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMSI---QGFDVKALRAFRVLRPLRLVSGVPS 618
Y R+ WNI DFI V+ + IL+ + GF++ L+ FR R ++L+ +
Sbjct: 1447 ---NYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYT 1503
Query: 619 LQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTP 798
++++L +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1504 IRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF----------------------- 1540
Query: 799 CGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLE 978
N+ + E N +N +F FG ML +F+ + E
Sbjct: 1541 ------------------GNIKLDEESHINR-----HNNFRSF--FGSLML-LFRSATGE 1574
Query: 979 GWTDVMYWV------------------NDAVGREWPWIYFVTLVILGSFFVLNLVLGVLS 1104
W ++M N+ G + ++YFV+ + SF +LNL + V+
Sbjct: 1575 AWQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIM 1634
Query: 1105 GEF 1113
F
Sbjct: 1635 DNF 1637
Score = 86.3 bits (212), Expect = 8e-15
Identities = 80/346 (23%), Positives = 152/346 (43%), Gaps = 9/346 (2%)
Frame = +1
Query: 232 RKLCISI---VEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
R L ISI V+ + F +++L ++ N +AI Q + LL E++F+ +F
Sbjct: 374 RLLRISIRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQ---WLTHLLYYAEFLFLGLF 430
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKALRAF 576
+E LK+ MG P Y +++N DF + V G + ++ + G F + LRA
Sbjct: 431 LLEMSLKMYGMG----PRLYFHSSFNCFDFGVTV-GSIFEVVWAIFRPGTSFGISVLRAL 485
Query: 577 RVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI 756
R+LR ++ SL+ ++ +++ +M ++ + L+ I+++A++G++LF G+ +
Sbjct: 486 RLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFN-- 543
Query: 757 DPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNF 936
D TP NFD F
Sbjct: 544 ----------DGTPSA---------------------------------------NFDTF 554
Query: 937 GLAMLTVFQCVSLEGWTDVMYWVNDAVG----REWPWIYFVTLVILGSFFVLNLVLGVLS 1104
A++TVFQ ++ E W +VMY + G W IYF+ L + G++ +LN+ L +
Sbjct: 555 PAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAIYFIVLTLFGNYTLLNVFLAIAV 614
Query: 1105 GEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVN 1242
+ Q+ + +Q EE+ + +A+++ P++
Sbjct: 615 DNLANA----------QELTKDEQEEEEAFNQKHALQKAKEVSPMS 650
Score = 79.0 bits (193), Expect = 1e-12
Identities = 104/484 (21%), Positives = 184/484 (37%), Gaps = 46/484 (9%)
Frame = +1
Query: 1534 FVILFSMEMLLKMYSLGFTTYTTSQF----NRFDCFVVISSILEFVLVY-FDLMKPLGVS 1698
F +F+ EM++KM G S F N D VV+ +++ F L K +
Sbjct: 1104 FTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIK 1163
Query: 1699 VLRSARLLRIF---KVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFG 1869
++S R+LR+ K K +Q+F
Sbjct: 1164 TIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFK 1223
Query: 1870 GKFNF---------------------NPQQPKPRA------NFDTFVQALLTVFQILTGE 1968
GKF + N + K R ++D + ALLT+F + TGE
Sbjct: 1224 GKFFYCTDSSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGE 1283
Query: 1969 DWNTVMYHGI----ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLAD-ADS 2133
W V+ H + E G + + + I+Y+V F+ + +N+F+A+ + + D
Sbjct: 1284 GWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDK 1343
Query: 2134 LTNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSARPRRMSEVPAASTVKP 2313
+ S + + A + KP
Sbjct: 1344 MMEE-------------------------------------CSLEKNERACIDFAISAKP 1366
Query: 2314 IPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMIL 2493
+ + HT +RV+ + VV+ S F ++ I +++ +L + A T + L
Sbjct: 1367 LTRYMPQ--NRHTFQYRVW-HFVVSPS-FEYTIMAMIALNTVVLMMK-YYSAPCTYELAL 1421
Query: 2494 NYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSX 2673
Y + FT VF++E LKVI FG + ++ R+ +N+ D + V S+T +L TD+
Sbjct: 1422 KYLNIAFTMVFSLECVLKVIAFGFL----NYFRDTWNIFDFITVIGSITEIIL-TDSKLV 1476
Query: 2674 XXXXXXXXXXXXXXAINRAKGLKH------VVQCVIVAVKTIGNIMLVTFMLQFMFAIIG 2835
A K L+ ++ + + K + + L+ ML F++AIIG
Sbjct: 1477 NTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIG 1536
Query: 2836 VQLF 2847
+Q+F
Sbjct: 1537 MQVF 1540
Score = 77.8 bits (190), Expect = 3e-12
Identities = 75/303 (24%), Positives = 124/303 (40%), Gaps = 53/303 (17%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACKHY-------PSSRGFEDFLDVFNLIFTGVFAFEAVLKIVAL 3513
FEY+I I+ N + LA + + P SR E F G+F FEA +KIVAL
Sbjct: 2 FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT----EPYFIGIFCFEAGIKIVAL 57
Query: 3514 ----NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNL---ISINFFRLFRVMRLVK 3672
+ +Y+ + WNV D +VV+ G L GT+ + + R RV+R +K
Sbjct: 58 GFIFHKGSYLRNGWNVMDFIVVLS-------GILATAGTHFNTHVDLRTLRAVRVLRPLK 110
Query: 3673 LLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHR--- 3843
L+S ++ +L + MK+ L + LL+ ++A+IG++F+ S +HR
Sbjct: 111 LVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY-------SGKLHRACF 163
Query: 3844 -NNN-----------------------------------FHSFPAAILVLFRSATGEAWQ 3915
NN+ F + A+L +F+ T E W
Sbjct: 164 MNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWT 223
Query: 3916 DIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIM 4095
++ + +D G + + YFI ++ SF V+NL + V+
Sbjct: 224 TVLYNTND---------------------ALGATWNWLYFIPLIIIGSFFVLNLVLGVLS 262
Query: 4096 DNF 4104
F
Sbjct: 263 GEF 265
Score = 76.6 bits (187), Expect = 6e-12
Identities = 116/586 (19%), Positives = 203/586 (33%), Gaps = 71/586 (12%)
Frame = +1
Query: 1531 FFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVS 1698
+F+ +F E +K+ +LGF +Y + +N D VV+S IL +F+ L
Sbjct: 41 YFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDL--R 98
Query: 1699 VLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF 1878
LR+ R+LR K+ G++ + GK
Sbjct: 99 TLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKL 158
Query: 1879 N-------------FNPQQP-------------------KPRANFDTFVQALLTVFQILT 1962
+ F+P P FD + A+LTVFQ +T
Sbjct: 159 HRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCIT 218
Query: 1963 GEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLA------- 2121
E W TV+Y+ ++ G +Y+I L I G++ +LN+ L + A
Sbjct: 219 MEGWTTVLYNTNDALGATWNW-----LYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVE 273
Query: 2122 ------------DADSLTNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSA 2265
+ N T A
Sbjct: 274 NRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEA 333
Query: 2266 RPRRMSE---VPAASTVKPIPKASSL--------FILSHTNSFRVFCNMVVNHSYFTNAV 2412
R S+ V +S P+ +AS + R+ +V F V
Sbjct: 334 MTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYWIV 393
Query: 2413 LFCILVSSAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFG--LVFHKGSF 2586
L + +++A +A Q ++ L Y ++ F +F +E++LK+ G L FH
Sbjct: 394 LSLVALNTACVAIVHHNQPQWLTHL-LYYAEFLFLGLFLLEMSLKMYGMGPRLYFH---- 448
Query: 2587 CRNAFNLLDILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQC 2757
++FN D V S+ V K L+++V
Sbjct: 449 --SSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVS 506
Query: 2758 VIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDP 2937
++ ++K+I +++ + F+ +FA++G+QLF G F ++ DG P
Sbjct: 507 LMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF-------------------NFNDGTP 547
Query: 2938 TKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
+ NFD A++++F + T E W +++Y I S
Sbjct: 548 SA-------------NFDTFPAAIMTVFQILTGEDWNEVMYNGIRS 580
Score = 69.7 bits (169), Expect = 8e-10
Identities = 62/244 (25%), Positives = 104/244 (42%), Gaps = 18/244 (7%)
Frame = +1
Query: 2398 FTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYFDYFFTSVFTVEITLKVIVFGLVF 2571
F +L I+ + +LA E L + M L + +F +F E +K++ G +F
Sbjct: 2 FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 61
Query: 2572 HKGSFCRNAFNLLDILVV-----AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKG 2736
HKGS+ RN +N++D +VV A + T F D + ++
Sbjct: 62 HKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLRT----LRAVRVLRPLKLVSGIPS 117
Query: 2737 LKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYI 2916
L+ V++ ++ A+ + I L+ F MFAIIG++ + G K+ A
Sbjct: 118 LQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSG---------KLHRACFMNNSG 168
Query: 2917 HYEDGDPTKPVS----------KKRVWSNNDF-NFDNVGDAMISLFVVSTFEGWPQLLYV 3063
E DP P K + N+ FDN+ A++++F T EGW +LY
Sbjct: 169 ILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYN 228
Query: 3064 AIDS 3075
D+
Sbjct: 229 TNDA 232
Score = 66.2 bits (160), Expect = 9e-09
Identities = 52/214 (24%), Positives = 86/214 (39%), Gaps = 17/214 (7%)
Frame = +1
Query: 1525 NLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLG--VS 1698
N+ F ++FS+E +LK+ + GF Y +N FD VI SI E +L L+ G +S
Sbjct: 1425 NIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMS 1484
Query: 1699 VLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF 1878
L+ R R+ K+ + GMQVFG
Sbjct: 1485 FLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIK 1544
Query: 1879 NFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFG---------------G 2013
NF +F +L+ +F+ TGE W +M + G
Sbjct: 1545 LDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQNENER 1604
Query: 2014 VGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDN 2115
GT + +Y++ ++++LN+F+A+ +DN
Sbjct: 1605 CGT--DLAYVYFVSFIFFCSFLMLNLFVAVIMDN 1636
>gi|1082919|pir||A54972 voltage-dependent calcium channel alpha 1E-3 -
human
gi|495870|gb|AAA59205.1| voltage-dependent calcium channel alpha-1E-3
Length = 2270
Score = 663 bits (1710), Expect = 0.0
Identities = 353/774 (45%), Positives = 484/774 (61%), Gaps = 13/774 (1%)
Frame = +1
Query: 2302 TVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTR 2481
T K + SS+FI S TN R C+ +VN YF +L I SS LAAEDP+ NS R
Sbjct: 1123 TGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSER 1182
Query: 2482 NMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTD 2661
N +L YFDY FT VFT E+ +K+I GL+ GS+ R+ +N+LD +VV +L +F L
Sbjct: 1183 NKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANA 1242
Query: 2662 A-------MSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFM 2820
+ I R LK V CV+ ++K + NI++V + F+
Sbjct: 1243 LGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFI 1302
Query: 2821 FAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVG 3000
FA+I VQLFKG FF C D SK TE EC G Y+ +E K K R W ++F++DN+
Sbjct: 1303 FAVIAVQLFKGKFFYCTDSSKDTEKECIGNYVDHEKN---KMEVKGREWKRHEFHYDNII 1359
Query: 3001 DAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXX 3180
A+++LF VST EGWPQ+L ++D EED+GP ++R +++
Sbjct: 1360 WALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFV 1419
Query: 3181 GFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRA 3354
+I+TFQ +G++ E C L+KN+R CI+FA+ AKP RY+P+NR QYRVW FV S +
Sbjct: 1420 ALIIITFQEQGDKMMEECSLEKNERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPS 1479
Query: 3355 FEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYIS 3534
FEY I +I +NTV L K+Y + +E L N+ FT VF+ E VLK++A NY
Sbjct: 1480 FEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFR 1539
Query: 3535 DRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWT 3714
D WN+FD + V+GS +I T+ +++F +LFR RL+KLL +G IR LLWT
Sbjct: 1540 DTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWT 1599
Query: 3715 FMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRS 3894
F++SF+ALPYV LLI +LFFIYA+IGMQ FG + LD+ + I+R+NNF SF ++++LFRS
Sbjct: 1600 FVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRS 1659
Query: 3895 ATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNES-RCGNNFAYPYFISFFMLCSFLVI 4071
ATGEAWQ+IMLSC + C+P D G NE+ RCG + AY YF+SF CSFL++
Sbjct: 1660 ATGEAWQEIMLSCLGEKG--CEP--DTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLML 1715
Query: 4072 NLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPL 4251
NLFVAVIMDNF+YLTRD SILGPHHL+EFVR+W+EYD A GRI + ++ +L +SPPL
Sbjct: 1716 NLFVAVIMDNFEYLTRDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPL 1775
Query: 4252 GFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKI-YTEGNID--EANEQL 4422
G GK CP ++A KRLV MNMP+ D TV F +TL AL+RT L I +G D + + +L
Sbjct: 1776 GLGKRCPSKVAYKRLVLMNMPVAEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSEL 1835
Query: 4423 RSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEME 4584
+ IW + +LD +V P K D+TVGK YA +I DY+++ K +K+ +
Sbjct: 1836 QKETLAIWPHLSQKMLDLLV-PMPKASDLTVGKIYAAMMIMDYYKQSKVKKQRQ 1888
Score = 514 bits (1323), Expect = e-143
Identities = 286/667 (42%), Positives = 373/667 (55%), Gaps = 27/667 (4%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N +RK +++W PFE++IL I ANCI LA+ Q P D + LE E FI +
Sbjct: 75 DNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGI 134
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KIVA+GF+FH +YLRN WN++DFI+V+ G+++T + + D++ LRA R
Sbjct: 135 FCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTH-VDLRTLRAVR 193
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQ+VL +I++AM+PLL I LL+ F IL++AIIGLE + GKLH C
Sbjct: 194 VLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFM 253
Query: 760 PATGQLAQKDPT-PCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNF 936
+G L DP PCG + ++C+ W GPN+GIT FDN
Sbjct: 254 NNSGILEGFDPPHPCGVQGCPAGYECKD------------------WIGPNDGITQFDNI 295
Query: 937 GLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFS 1116
A+LTVFQC+++EGWT V+Y NDA+G W W+YF+ L+I+GSFFVLNLVLGVLSGEF+
Sbjct: 296 LFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFA 355
Query: 1117 KEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNED---------------- 1248
KERE+ R F K R +QQ+E +L GY WI +AE++ E+
Sbjct: 356 KERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATI 415
Query: 1249 ----------EQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXX 1398
+ DE + +RL +++
Sbjct: 416 KRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRIS------I 469
Query: 1399 XXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYS 1578
+VKSQ FYW H+ Q +WL H A F+ LF +EM LKMY
Sbjct: 470 RHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYG 529
Query: 1579 LGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXX 1758
+G Y S FN FD V + SI E V F G+SVLR+ RLLRIFK+TKYW
Sbjct: 530 MGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASL 589
Query: 1759 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQAL 1938
GMQ+FGG+FNFN P ANFDTF A+
Sbjct: 590 RNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFN--DGTPSANFDTFPAAI 647
Query: 1939 LTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNL 2118
+TVFQILTGEDWN VMY+GI S GGV + G+ IY+IVL + GNY LLNVFLAIAVDNL
Sbjct: 648 MTVFQILTGEDWNEVMYNGIRSQGGVSS-GMWSAIYFIVLTLFGNYTLLNVFLAIAVDNL 706
Query: 2119 ADADSLT 2139
A+A LT
Sbjct: 707 ANAQELT 713
Score = 130 bits (327), Expect = 4e-28
Identities = 101/378 (26%), Positives = 172/378 (44%), Gaps = 14/378 (3%)
Frame = +1
Query: 139 KRPAQRKPLRQTNVVXXXXXXXXXXXXNNPIRKLCISIVEWKPFEFLILFMICANCIALA 318
++ Q+K R+T NPIR+ C IV + FE IL +I A+ IALA
Sbjct: 1112 EKKKQKKEKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALA 1171
Query: 319 IYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFII 498
P +N +L +YVF VFT E V+K++ G + +Y R+ WNILDF++
Sbjct: 1172 AEDPVLTNSE--RNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVV 1229
Query: 499 VVIGLVSTILSKM--SIQGFD---VKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPL 663
VV LV+ L+ + +G D +K+LR RVLRPL+ + +P L+ V + ++ ++ +
Sbjct: 1230 VVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNV 1289
Query: 664 LHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPS 843
+I ++ + I+A+I ++LF GK C D + DTE
Sbjct: 1290 FNILIVYKLFMFIFAVIAVQLFKGKFF-YCTDSS-------------KDTEKECIGNYVD 1335
Query: 844 DSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAV-- 1017
M V+ W ++DN A+LT+F + EGW V+ D
Sbjct: 1336 HEKNKMEVK-----GREW---KRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEE 1387
Query: 1018 -------GREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQQ 1176
R I++V ++ FF +N+ + ++ F ++ + K E+
Sbjct: 1388 DRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGD---------KMMEECS 1438
Query: 1177 LEEDLKGYLDWITQAEDI 1230
LE++ + +D+ A+ +
Sbjct: 1439 LEKNERACIDFAISAKPL 1456
Score = 115 bits (289), Expect = 9e-24
Identities = 72/273 (26%), Positives = 137/273 (49%), Gaps = 4/273 (1%)
Frame = +1
Query: 3316 LQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAV 3495
L+ + V S+ F +++ ++ +NT +A H+ + L +F G+F E
Sbjct: 465 LRISIRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMS 524
Query: 3496 LKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKL 3675
LK+ + P+ Y +N FD V VGS ++ + PG + I+ R R++R+ K+
Sbjct: 525 LKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTS--FGISVLRALRLLRIFKI 582
Query: 3676 LSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNN 3852
+R L+ + M S +++ + L+ L ++A++GMQ F G+ +D T + N
Sbjct: 583 TKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTP---SAN 639
Query: 3853 FHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPY 4032
F +FPAAI+ +F+ TGE W ++M + +R +GG++ ++ Y
Sbjct: 640 FDTFPAAIMTVFQILTGEDWNEVMYN-----GIR--------SQGGVSSGM----WSAIY 682
Query: 4033 FISFFMLCSFLVINLFVAVIMDNF---DYLTRD 4122
FI + ++ ++N+F+A+ +DN LT+D
Sbjct: 683 FIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 715
Score = 90.1 bits (222), Expect = 6e-16
Identities = 75/303 (24%), Positives = 133/303 (43%), Gaps = 21/303 (6%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+ I+ MI N + L + Y + Y+ L+ + F +VF++ECVLK++A GF+
Sbjct: 1480 FEYTIMAMIALNTVVLMM--KYYSAPCTYE-LALKYLNIAFTMVFSLECVLKVIAFGFL- 1535
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMSI---QGFDVKALRAFRVLRPLRLVSGVPS 618
Y R+ WNI DFI V+ + IL+ + GF++ L+ FR R ++L+ +
Sbjct: 1536 ---NYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYT 1592
Query: 619 LQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTP 798
++++L +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1593 IRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF----------------------- 1629
Query: 799 CGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLE 978
N+ + E N +N +F FG ML +F+ + E
Sbjct: 1630 ------------------GNIKLDEESHINR-----HNNFRSF--FGSLML-LFRSATGE 1663
Query: 979 GWTDVMYWV------------------NDAVGREWPWIYFVTLVILGSFFVLNLVLGVLS 1104
W ++M N+ G + ++YFV+ + SF +LNL + V+
Sbjct: 1664 AWQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIM 1723
Query: 1105 GEF 1113
F
Sbjct: 1724 DNF 1726
Score = 86.3 bits (212), Expect = 8e-15
Identities = 80/346 (23%), Positives = 152/346 (43%), Gaps = 9/346 (2%)
Frame = +1
Query: 232 RKLCISI---VEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
R L ISI V+ + F +++L ++ N +AI Q + LL E++F+ +F
Sbjct: 463 RLLRISIRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQ---WLTHLLYYAEFLFLGLF 519
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKALRAF 576
+E LK+ MG P Y +++N DF + V G + ++ + G F + LRA
Sbjct: 520 LLEMSLKMYGMG----PRLYFHSSFNCFDFGVTV-GSIFEVVWAIFRPGTSFGISVLRAL 574
Query: 577 RVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI 756
R+LR ++ SL+ ++ +++ +M ++ + L+ I+++A++G++LF G+ +
Sbjct: 575 RLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFN-- 632
Query: 757 DPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNF 936
D TP NFD F
Sbjct: 633 ----------DGTPSA---------------------------------------NFDTF 643
Query: 937 GLAMLTVFQCVSLEGWTDVMYWVNDAVG----REWPWIYFVTLVILGSFFVLNLVLGVLS 1104
A++TVFQ ++ E W +VMY + G W IYF+ L + G++ +LN+ L +
Sbjct: 644 PAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAIYFIVLTLFGNYTLLNVFLAIAV 703
Query: 1105 GEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVN 1242
+ Q+ + +Q EE+ + +A+++ P++
Sbjct: 704 DNLANA----------QELTKDEQEEEEAFNQKHALQKAKEVSPMS 739
Score = 79.0 bits (193), Expect = 1e-12
Identities = 104/484 (21%), Positives = 184/484 (37%), Gaps = 46/484 (9%)
Frame = +1
Query: 1534 FVILFSMEMLLKMYSLGFTTYTTSQF----NRFDCFVVISSILEFVLVY-FDLMKPLGVS 1698
F +F+ EM++KM G S F N D VV+ +++ F L K +
Sbjct: 1193 FTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIK 1252
Query: 1699 VLRSARLLRIF---KVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFG 1869
++S R+LR+ K K +Q+F
Sbjct: 1253 TIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFK 1312
Query: 1870 GKFNF---------------------NPQQPKPRA------NFDTFVQALLTVFQILTGE 1968
GKF + N + K R ++D + ALLT+F + TGE
Sbjct: 1313 GKFFYCTDSSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGE 1372
Query: 1969 DWNTVMYHGI----ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLAD-ADS 2133
W V+ H + E G + + + I+Y+V F+ + +N+F+A+ + + D
Sbjct: 1373 GWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDK 1432
Query: 2134 LTNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSARPRRMSEVPAASTVKP 2313
+ S + + A + KP
Sbjct: 1433 MMEE-------------------------------------CSLEKNERACIDFAISAKP 1455
Query: 2314 IPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMIL 2493
+ + HT +RV+ + VV+ S F ++ I +++ +L + A T + L
Sbjct: 1456 LTRYMPQ--NRHTFQYRVW-HFVVSPS-FEYTIMAMIALNTVVLMMK-YYSAPCTYELAL 1510
Query: 2494 NYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSX 2673
Y + FT VF++E LKVI FG + ++ R+ +N+ D + V S+T +L TD+
Sbjct: 1511 KYLNIAFTMVFSLECVLKVIAFGFL----NYFRDTWNIFDFITVIGSITEIIL-TDSKLV 1565
Query: 2674 XXXXXXXXXXXXXXAINRAKGLKH------VVQCVIVAVKTIGNIMLVTFMLQFMFAIIG 2835
A K L+ ++ + + K + + L+ ML F++AIIG
Sbjct: 1566 NTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIG 1625
Query: 2836 VQLF 2847
+Q+F
Sbjct: 1626 MQVF 1629
Score = 79.0 bits (193), Expect = 1e-12
Identities = 68/267 (25%), Positives = 114/267 (42%), Gaps = 18/267 (6%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLFI N R + +++ F +L I+ + +LA E L + M L
Sbjct: 68 SLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT 127
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV-----AVSLTSFVLRTDAM 2667
+ +F +F E +K++ G +FHKGS+ RN +N++D +VV A + T F D
Sbjct: 128 EPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLR 187
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
+ ++ L+ V++ ++ A+ + I L+ F MFAIIG++ +
Sbjct: 188 T----LRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY 243
Query: 2848 KGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVS----------KKRVWSNNDF-NFDN 2994
G K+ A E DP P K + N+ FDN
Sbjct: 244 SG---------KLHRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDN 294
Query: 2995 VGDAMISLFVVSTFEGWPQLLYVAIDS 3075
+ A++++F T EGW +LY D+
Sbjct: 295 ILFAVLTVFQCITMEGWTTVLYNTNDA 321
Score = 77.8 bits (190), Expect = 3e-12
Identities = 75/303 (24%), Positives = 124/303 (40%), Gaps = 53/303 (17%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACKHY-------PSSRGFEDFLDVFNLIFTGVFAFEAVLKIVAL 3513
FEY+I I+ N + LA + + P SR E F G+F FEA +KIVAL
Sbjct: 91 FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT----EPYFIGIFCFEAGIKIVAL 146
Query: 3514 ----NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNL---ISINFFRLFRVMRLVK 3672
+ +Y+ + WNV D +VV+ G L GT+ + + R RV+R +K
Sbjct: 147 GFIFHKGSYLRNGWNVMDFIVVLS-------GILATAGTHFNTHVDLRTLRAVRVLRPLK 199
Query: 3673 LLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHR--- 3843
L+S ++ +L + MK+ L + LL+ ++A+IG++F+ S +HR
Sbjct: 200 LVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY-------SGKLHRACF 252
Query: 3844 -NNN-----------------------------------FHSFPAAILVLFRSATGEAWQ 3915
NN+ F + A+L +F+ T E W
Sbjct: 253 MNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWT 312
Query: 3916 DIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIM 4095
++ + +D G + + YFI ++ SF V+NL + V+
Sbjct: 313 TVLYNTND---------------------ALGATWNWLYFIPLIIIGSFFVLNLVLGVLS 351
Query: 4096 DNF 4104
F
Sbjct: 352 GEF 354
Score = 76.6 bits (187), Expect = 6e-12
Identities = 116/586 (19%), Positives = 203/586 (33%), Gaps = 71/586 (12%)
Frame = +1
Query: 1531 FFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVS 1698
+F+ +F E +K+ +LGF +Y + +N D VV+S IL +F+ L
Sbjct: 130 YFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDL--R 187
Query: 1699 VLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF 1878
LR+ R+LR K+ G++ + GK
Sbjct: 188 TLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKL 247
Query: 1879 N-------------FNPQQP-------------------KPRANFDTFVQALLTVFQILT 1962
+ F+P P FD + A+LTVFQ +T
Sbjct: 248 HRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCIT 307
Query: 1963 GEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLA------- 2121
E W TV+Y+ ++ G +Y+I L I G++ +LN+ L + A
Sbjct: 308 MEGWTTVLYNTNDALGATWNW-----LYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVE 362
Query: 2122 ------------DADSLTNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSA 2265
+ N T A
Sbjct: 363 NRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEA 422
Query: 2266 RPRRMSE---VPAASTVKPIPKASSL--------FILSHTNSFRVFCNMVVNHSYFTNAV 2412
R S+ V +S P+ +AS + R+ +V F V
Sbjct: 423 MTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYWIV 482
Query: 2413 LFCILVSSAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFG--LVFHKGSF 2586
L + +++A +A Q ++ L Y ++ F +F +E++LK+ G L FH
Sbjct: 483 LSLVALNTACVAIVHHNQPQWLTHL-LYYAEFLFLGLFLLEMSLKMYGMGPRLYFH---- 537
Query: 2587 CRNAFNLLDILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQC 2757
++FN D V S+ V K L+++V
Sbjct: 538 --SSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVS 595
Query: 2758 VIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDP 2937
++ ++K+I +++ + F+ +FA++G+QLF G F ++ DG P
Sbjct: 596 LMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF-------------------NFNDGTP 636
Query: 2938 TKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
+ NFD A++++F + T E W +++Y I S
Sbjct: 637 SA-------------NFDTFPAAIMTVFQILTGEDWNEVMYNGIRS 669
Score = 66.2 bits (160), Expect = 9e-09
Identities = 52/214 (24%), Positives = 86/214 (39%), Gaps = 17/214 (7%)
Frame = +1
Query: 1525 NLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLG--VS 1698
N+ F ++FS+E +LK+ + GF Y +N FD VI SI E +L L+ G +S
Sbjct: 1514 NIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMS 1573
Query: 1699 VLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF 1878
L+ R R+ K+ + GMQVFG
Sbjct: 1574 FLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIK 1633
Query: 1879 NFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFG---------------G 2013
NF +F +L+ +F+ TGE W +M + G
Sbjct: 1634 LDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQNENER 1693
Query: 2014 VGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDN 2115
GT + +Y++ ++++LN+F+A+ +DN
Sbjct: 1694 CGT--DLAYVYFVSFIFFCSFLMLNLFVAVIMDN 1725
>gi|478761|pir||S29237 calcium channel protein BII-2, brain - rabbit
gi|1475|emb|CAA48041.1| brain calcium channel BII-2 [Oryctolagus
cuniculus]
gi|742788|prf||2011160B Ca channel BII-2
Length = 2178
Score = 660 bits (1704), Expect = 0.0
Identities = 355/782 (45%), Positives = 486/782 (61%), Gaps = 13/782 (1%)
Frame = +1
Query: 2272 RRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAA 2451
++ E PA+ K + SS+FI S +N R C+ VVN YF +L I SS LAA
Sbjct: 1105 QKKKERPASG--KAMVPHSSMFIFSTSNPIRRACHYVVNLRYFEMCILLVIAASSIALAA 1162
Query: 2452 EDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAV 2631
EDP+ NS RN +L YFDY FT VFT E+ +K+I GL+ GS+ R+ +N+LD +VV
Sbjct: 1163 EDPVLTNSERNRVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVG 1222
Query: 2632 SLTSFVLRTDA-------MSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNI 2790
+L +F L + I R LK V CV+ ++K + NI
Sbjct: 1223 ALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNI 1282
Query: 2791 MLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWS 2970
++V + F+FA+I VQLFKG FF C D SK TE EC G Y+ +E K K R W
Sbjct: 1283 LIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEKECIGNYVDHEKN---KMEVKGREWK 1339
Query: 2971 NNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXX 3150
++F++DN+ A+++LF VST EGWPQ+L ++D EED+GP ++R +++
Sbjct: 1340 RHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVV 1399
Query: 3151 XXXXXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQY 3324
+I+TFQ +G++ E C L+KN+R CI+FA+ AKP RY+P+NR QY
Sbjct: 1400 FPFFFVNIFVALIIITFQEQGDKMMEECSLEKNERACIDFAISAKPLTRYMPQNRHTFQY 1459
Query: 3325 RVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKI 3504
RVW FV S +FEY I +I +NTV L K+Y + +E L N+ FT VF+ E VLK+
Sbjct: 1460 RVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKV 1519
Query: 3505 VALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSR 3684
+A NY D WN+FD + V+GS +I T +++F +LFR RL+KLL +
Sbjct: 1520 IAFGFVNYFRDTWNIFDFITVIGSITEIVLTDSKLVNTTGFNMSFLKLFRAARLIKLLRQ 1579
Query: 3685 GEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSF 3864
G IR LLWTF++SF+ALPYV LLI +LFFIYA+IGMQ FG + LD+ + I+R+NNF SF
Sbjct: 1580 GYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIRLDEESHINRHNNFRSF 1639
Query: 3865 PAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNES-RCGNNFAYPYFIS 4041
++++LFRSATGEAWQ+IMLSC + C+P D G ES RCG + AY YF+S
Sbjct: 1640 FGSLMLLFRSATGEAWQEIMLSCLGEKG--CEP--DTTAPSGQQESERCGTDLAYVYFVS 1695
Query: 4042 FFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVV 4221
F CSFL++NLFVAVIMDNF+YLTRD SILGPHHL+EFVR+W+EYD A GRI + ++
Sbjct: 1696 FIFFCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMY 1755
Query: 4222 TLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKI-YTEGN 4398
+L +SPPLG GK CP ++A KRLV MNMP+ D TV F +TL AL+RT L I +G
Sbjct: 1756 EMLTLMSPPLGLGKRCPSKVAYKRLVLMNMPVAEDMTVHFTSTLMALIRTALDIKIAKGG 1815
Query: 4399 ID--EANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKR 4572
D + + +L+ IW + +LD +V P K D+TVGK YA +I DY+++ K +
Sbjct: 1816 ADRQQLDSELQKETLAIWPHLSQKMLDLLV-PMPKASDLTVGKIYAAMMIMDYYKQSKVK 1874
Query: 4573 KE 4578
K+
Sbjct: 1875 KQ 1876
Score = 514 bits (1324), Expect = e-144
Identities = 285/667 (42%), Positives = 373/667 (55%), Gaps = 27/667 (4%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N +RK +++W PFE++IL I ANCI LA+ Q P D + LE E FI +
Sbjct: 75 DNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGI 134
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KIVA+GF+FH +YLRN WN++DFI+V+ G+++T + + D++ LRA R
Sbjct: 135 FCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTH-VDLRTLRAVR 193
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQ+VL +I++AM+PLL I LL+ F IL++AIIGLE + GKLH C
Sbjct: 194 VLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFV 253
Query: 760 PATGQLAQKDPT-PCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNF 936
+G L DP PCG + ++C+ W GPN+GIT FDN
Sbjct: 254 NNSGVLEGFDPPHPCGVQGCPAGYECKD------------------WIGPNDGITQFDNI 295
Query: 937 GLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFS 1116
A+LTVFQC+++EGWT V+Y NDA+G W W+YF+ L+I+GSFFVLNLVLGVLSGEF+
Sbjct: 296 LFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFA 355
Query: 1117 KEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNED---------------- 1248
KERE+ R F K R +QQ+E +L GY WI +AE++ E+
Sbjct: 356 KERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNSGTSALEVLRRATI 415
Query: 1249 ----------EQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXX 1398
+ DE + + +RL +++
Sbjct: 416 KRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGASYFRHKERLLRISVRHA--- 472
Query: 1399 XXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYS 1578
VKSQ FYW H+ Q +WL H A F+ LF +EM LKMY
Sbjct: 473 ---VKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYG 529
Query: 1579 LGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXX 1758
+G Y S FN FD V + SI E V F G+SVLR+ RLLRIFK+TKYW
Sbjct: 530 MGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASL 589
Query: 1759 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQAL 1938
GMQ+FGG+FNFN P ANFDTF A+
Sbjct: 590 RNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFN--DGTPSANFDTFPAAI 647
Query: 1939 LTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNL 2118
+TVFQILTGEDWN VMY+GI S GGV + G+ +Y+IVL + GNY LLNVFLAIAVDNL
Sbjct: 648 MTVFQILTGEDWNEVMYNGIRSQGGVSS-GMWSAVYFIVLTLFGNYTLLNVFLAIAVDNL 706
Query: 2119 ADADSLT 2139
A+A LT
Sbjct: 707 ANAQELT 713
Score = 126 bits (316), Expect = 7e-27
Identities = 96/351 (27%), Positives = 165/351 (46%), Gaps = 14/351 (3%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+NPIR+ C +V + FE IL +I A+ IALA P +N +L +YVF V
Sbjct: 1129 SNPIRRACHYVVNLRYFEMCILLVIAASSIALAAEDPVLTNSE--RNRVLRYFDYVFTGV 1186
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKM--SIQGFD---VKA 564
FT E V+K++ G + +Y R+ WNILDF++VV LV+ L+ + +G D +K+
Sbjct: 1187 FTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKS 1246
Query: 565 LRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLH 744
LR RVLRPL+ + +P L+ V + ++ ++ + +I ++ + I+A+I ++LF GK
Sbjct: 1247 LRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFF 1306
Query: 745 STCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITN 924
C D + DTE M V+ W +
Sbjct: 1307 -YCTDSS-------------KDTEKECIGNYVDHEKNKMEVK-----GREW---KRHEFH 1344
Query: 925 FDNFGLAMLTVFQCVSLEGWTDVMYWVNDAV---------GREWPWIYFVTLVILGSFFV 1077
+DN A+LT+F + EGW V+ D R I++V ++ FF
Sbjct: 1345 YDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFF 1404
Query: 1078 LNLVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDI 1230
+N+ + ++ F ++ + K E+ LE++ + +D+ A+ +
Sbjct: 1405 VNIFVALIIITFQEQGD---------KMMEECSLEKNERACIDFAISAKPL 1446
Score = 115 bits (289), Expect = 9e-24
Identities = 71/265 (26%), Positives = 134/265 (49%), Gaps = 4/265 (1%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S+ F +++ ++ +NT +A H+ + L +F G+F E LK+ + P
Sbjct: 473 VKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGP 532
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD V VGS ++ + PG + I+ R R++R+ K+ +R
Sbjct: 533 RLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTS--FGISVLRALRLLRIFKITKYWASLR 590
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + M S +++ + L+ L ++A++GMQ F G+ +D T + NF +FPAAI
Sbjct: 591 NLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTP---SANFDTFPAAI 647
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLC 4056
+ +F+ TGE W ++M + +R +GG++ ++ YFI +
Sbjct: 648 MTVFQILTGEDWNEVMYN-----GIR--------SQGGVSSGM----WSAVYFIVLTLFG 690
Query: 4057 SFLVINLFVAVIMDNF---DYLTRD 4122
++ ++N+F+A+ +DN LT+D
Sbjct: 691 NYTLLNVFLAIAVDNLANAQELTKD 715
Score = 87.0 bits (214), Expect = 5e-15
Identities = 73/303 (24%), Positives = 133/303 (43%), Gaps = 21/303 (6%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+ I+ MI N + L + Y + Y+ L+ + F +VF++ECVLK++A GF+
Sbjct: 1470 FEYTIMAMIALNTVVLMM--KYYSAPCTYE-LALKYLNIAFTMVFSLECVLKVIAFGFV- 1525
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMSI---QGFDVKALRAFRVLRPLRLVSGVPS 618
Y R+ WNI DFI V+ + +L+ + GF++ L+ FR R ++L+ +
Sbjct: 1526 ---NYFRDTWNIFDFITVIGSITEIVLTDSKLVNTTGFNMSFLKLFRAARLIKLLRQGYT 1582
Query: 619 LQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTP 798
++++L +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1583 IRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF----------------------- 1619
Query: 799 CGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLE 978
N+ + E N +N +F FG ML +F+ + E
Sbjct: 1620 ------------------GNIRLDEESHINR-----HNNFRSF--FGSLML-LFRSATGE 1653
Query: 979 GWTDVM------------------YWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLS 1104
W ++M ++ G + ++YFV+ + SF +LNL + V+
Sbjct: 1654 AWQEIMLSCLGEKGCEPDTTAPSGQQESERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIM 1713
Query: 1105 GEF 1113
F
Sbjct: 1714 DNF 1716
Score = 85.5 bits (210), Expect = 1e-14
Identities = 78/346 (22%), Positives = 152/346 (43%), Gaps = 9/346 (2%)
Frame = +1
Query: 232 RKLCISI---VEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
R L IS+ V+ + F +++L ++ N +AI Q + LL E++F+ +F
Sbjct: 463 RLLRISVRHAVKSQVFYWIVLSLVALNTACVAIVHHNQPQ---WLTHLLYYAEFLFLGLF 519
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKALRAF 576
+E LK+ MG P Y +++N DF + V G + ++ + G F + LRA
Sbjct: 520 LLEMSLKMYGMG----PRLYFHSSFNCFDFGVTV-GSIFEVVWAIFRPGTSFGISVLRAL 574
Query: 577 RVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI 756
R+LR ++ SL+ ++ +++ +M ++ + L+ I+++A++G++LF G+ +
Sbjct: 575 RLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFN-- 632
Query: 757 DPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNF 936
D TP NFD F
Sbjct: 633 ----------DGTPSA---------------------------------------NFDTF 643
Query: 937 GLAMLTVFQCVSLEGWTDVMYWVNDAVG----REWPWIYFVTLVILGSFFVLNLVLGVLS 1104
A++TVFQ ++ E W +VMY + G W +YF+ L + G++ +LN+ L +
Sbjct: 644 PAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAVYFIVLTLFGNYTLLNVFLAIAV 703
Query: 1105 GEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVN 1242
+ Q+ + +Q EE+ + +A+++ P++
Sbjct: 704 DNLANA----------QELTKDEQEEEEAFNQKHALQKAKEVSPMS 739
Score = 80.5 bits (197), Expect = 4e-13
Identities = 106/484 (21%), Positives = 184/484 (37%), Gaps = 46/484 (9%)
Frame = +1
Query: 1534 FVILFSMEMLLKMYSLGFTTYTTSQF----NRFDCFVVISSILEFVLVY-FDLMKPLGVS 1698
F +F+ EM++KM G S F N D VV+ +++ F L K +
Sbjct: 1183 FTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIK 1242
Query: 1699 VLRSARLLRIF---KVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFG 1869
++S R+LR+ K K +Q+F
Sbjct: 1243 TIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFK 1302
Query: 1870 GKFNF---------------------NPQQPKPRA------NFDTFVQALLTVFQILTGE 1968
GKF + N + K R ++D + ALLT+F + TGE
Sbjct: 1303 GKFFYCTDSSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGE 1362
Query: 1969 DWNTVMYHGI----ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLAD-ADS 2133
W V+ H + E G + + + I+Y+V F+ + +N+F+A+ + + D
Sbjct: 1363 GWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDK 1422
Query: 2134 LTNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSARPRRMSEVPAASTVKP 2313
+ S + + A + KP
Sbjct: 1423 MMEE-------------------------------------CSLEKNERACIDFAISAKP 1445
Query: 2314 IPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMIL 2493
+ + HT +RV+ + VV+ S F ++ I +++ +L + A T + L
Sbjct: 1446 LTRYMPQ--NRHTFQYRVW-HFVVSPS-FEYTIMAMIALNTVVLMMK-YYSAPCTYELAL 1500
Query: 2494 NYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSX 2673
Y + FT VF++E LKVI FG V ++ R+ +N+ D + V S+T VL TD+
Sbjct: 1501 KYLNIAFTMVFSLECVLKVIAFGFV----NYFRDTWNIFDFITVIGSITEIVL-TDSKLV 1555
Query: 2674 XXXXXXXXXXXXXXAINRAKGLKH------VVQCVIVAVKTIGNIMLVTFMLQFMFAIIG 2835
A K L+ ++ + + K + + L+ ML F++AIIG
Sbjct: 1556 NTTGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIG 1615
Query: 2836 VQLF 2847
+Q+F
Sbjct: 1616 MQVF 1619
Score = 78.6 bits (192), Expect = 2e-12
Identities = 76/300 (25%), Positives = 125/300 (41%), Gaps = 28/300 (9%)
Frame = +1
Query: 2260 SARPRRMSEVPAASTV---KPIPKAS-------SLFILSHTNSFRVFCNMVVNHSYFTNA 2409
SA + S+ A T+ PIP SLFI N R + +++ F
Sbjct: 35 SAAAYKQSKAQRARTMALYNPIPVRQNCFTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYM 94
Query: 2410 VLFCILVSSAMLAAEDPLQANSTRNMI--LNYFDYFFTSVFTVEITLKVIVFGLVFHKGS 2583
+L I+ + +LA E L + M L + +F +F E +K++ G +FHKGS
Sbjct: 95 ILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIFHKGS 154
Query: 2584 FCRNAFNLLDILVV-----AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHV 2748
+ RN +N++D +VV A + T F D + ++ L+ V
Sbjct: 155 YLRNGWNVMDFIVVLSGILATAGTHFNTHVDLRT----LRAVRVLRPLKLVSGIPSLQIV 210
Query: 2749 VQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYED 2928
++ ++ A+ + I L+ F MFAIIG++ + G K+ A E
Sbjct: 211 LKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSG---------KLHRACFVNNSGVLEG 261
Query: 2929 GDPTKPVS----------KKRVWSNNDF-NFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
DP P K + N+ FDN+ A++++F T EGW +LY D+
Sbjct: 262 FDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDA 321
Score = 77.8 bits (190), Expect = 3e-12
Identities = 75/303 (24%), Positives = 124/303 (40%), Gaps = 53/303 (17%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACKHY-------PSSRGFEDFLDVFNLIFTGVFAFEAVLKIVAL 3513
FEY+I I+ N + LA + + P SR E F G+F FEA +KIVAL
Sbjct: 91 FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT----EPYFIGIFCFEAGIKIVAL 146
Query: 3514 ----NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNL---ISINFFRLFRVMRLVK 3672
+ +Y+ + WNV D +VV+ G L GT+ + + R RV+R +K
Sbjct: 147 GFIFHKGSYLRNGWNVMDFIVVLS-------GILATAGTHFNTHVDLRTLRAVRVLRPLK 199
Query: 3673 LLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHR--- 3843
L+S ++ +L + MK+ L + LL+ ++A+IG++F+ S +HR
Sbjct: 200 LVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY-------SGKLHRACF 252
Query: 3844 -NNN-----------------------------------FHSFPAAILVLFRSATGEAWQ 3915
NN+ F + A+L +F+ T E W
Sbjct: 253 VNNSGVLEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWT 312
Query: 3916 DIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIM 4095
++ + +D G + + YFI ++ SF V+NL + V+
Sbjct: 313 TVLYNTND---------------------ALGATWNWLYFIPLIIIGSFFVLNLVLGVLS 351
Query: 4096 DNF 4104
F
Sbjct: 352 GEF 354
Score = 77.4 bits (189), Expect = 4e-12
Identities = 116/586 (19%), Positives = 203/586 (33%), Gaps = 71/586 (12%)
Frame = +1
Query: 1531 FFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVS 1698
+F+ +F E +K+ +LGF +Y + +N D VV+S IL +F+ L
Sbjct: 130 YFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDL--R 187
Query: 1699 VLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF 1878
LR+ R+LR K+ G++ + GK
Sbjct: 188 TLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKL 247
Query: 1879 N-------------FNPQQP-------------------KPRANFDTFVQALLTVFQILT 1962
+ F+P P FD + A+LTVFQ +T
Sbjct: 248 HRACFVNNSGVLEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCIT 307
Query: 1963 GEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLA------- 2121
E W TV+Y+ ++ G +Y+I L I G++ +LN+ L + A
Sbjct: 308 MEGWTTVLYNTNDALGATWNW-----LYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVE 362
Query: 2122 ------------DADSLTNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSA 2265
+ N T A
Sbjct: 363 NRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNSGTSALEVLRRATIKRSRTEA 422
Query: 2266 RPRRMSE---VPAASTVKPIPKAS--------SLFILSHTNSFRVFCNMVVNHSYFTNAV 2412
R S+ V +S P+ +AS + + R+ V F V
Sbjct: 423 MTRDSSDEHCVDISSVGTPLARASIKSAKVDGASYFRHKERLLRISVRHAVKSQVFYWIV 482
Query: 2413 LFCILVSSAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFG--LVFHKGSF 2586
L + +++A +A Q ++ L Y ++ F +F +E++LK+ G L FH
Sbjct: 483 LSLVALNTACVAIVHHNQPQWLTHL-LYYAEFLFLGLFLLEMSLKMYGMGPRLYFH---- 537
Query: 2587 CRNAFNLLDILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQC 2757
++FN D V S+ V K L+++V
Sbjct: 538 --SSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVS 595
Query: 2758 VIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDP 2937
++ ++K+I +++ + F+ +FA++G+QLF G F ++ DG P
Sbjct: 596 LMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF-------------------NFNDGTP 636
Query: 2938 TKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
+ NFD A++++F + T E W +++Y I S
Sbjct: 637 SA-------------NFDTFPAAIMTVFQILTGEDWNEVMYNGIRS 669
Score = 67.8 bits (164), Expect = 3e-09
Identities = 53/214 (24%), Positives = 86/214 (39%), Gaps = 17/214 (7%)
Frame = +1
Query: 1525 NLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLG--VS 1698
N+ F ++FS+E +LK+ + GF Y +N FD VI SI E VL L+ G +S
Sbjct: 1504 NIAFTMVFSLECVLKVIAFGFVNYFRDTWNIFDFITVIGSITEIVLTDSKLVNTTGFNMS 1563
Query: 1699 VLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF 1878
L+ R R+ K+ + GMQVFG
Sbjct: 1564 FLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIR 1623
Query: 1879 NFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMY---------------HGIESFGG 2013
NF +F +L+ +F+ TGE W +M G +
Sbjct: 1624 LDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQQESER 1683
Query: 2014 VGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDN 2115
GT + +Y++ ++++LN+F+A+ +DN
Sbjct: 1684 CGT--DLAYVYFVSFIFFCSFLMLNLFVAVIMDN 1715
>gi|399202|sp|Q02343|CCAE_RABIT Voltage-dependent R-type calcium
channel alpha-1E subunit (Voltage-gated calcium channel
alpha subunit Cav2.3) (Calcium channel, L type, alpha-1
polypeptide, isoform 6) (Brain calcium channel II) (BII)
gi|478760|pir||S29236 calcium channel protein BII-1, brain - rabbit
gi|1473|emb|CAA48040.1| brain calcium channel BII-1 [Oryctolagus
cuniculus]
gi|742787|prf||2011160A Ca channel BII-1
Length = 2259
Score = 660 bits (1704), Expect = 0.0
Identities = 355/782 (45%), Positives = 486/782 (61%), Gaps = 13/782 (1%)
Frame = +1
Query: 2272 RRMSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAA 2451
++ E PA+ K + SS+FI S +N R C+ VVN YF +L I SS LAA
Sbjct: 1105 QKKKERPASG--KAMVPHSSMFIFSTSNPIRRACHYVVNLRYFEMCILLVIAASSIALAA 1162
Query: 2452 EDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAV 2631
EDP+ NS RN +L YFDY FT VFT E+ +K+I GL+ GS+ R+ +N+LD +VV
Sbjct: 1163 EDPVLTNSERNRVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVG 1222
Query: 2632 SLTSFVLRTDA-------MSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNI 2790
+L +F L + I R LK V CV+ ++K + NI
Sbjct: 1223 ALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNI 1282
Query: 2791 MLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWS 2970
++V + F+FA+I VQLFKG FF C D SK TE EC G Y+ +E K K R W
Sbjct: 1283 LIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEKECIGNYVDHEKN---KMEVKGREWK 1339
Query: 2971 NNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXX 3150
++F++DN+ A+++LF VST EGWPQ+L ++D EED+GP ++R +++
Sbjct: 1340 RHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVV 1399
Query: 3151 XXXXXXXXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQY 3324
+I+TFQ +G++ E C L+KN+R CI+FA+ AKP RY+P+NR QY
Sbjct: 1400 FPFFFVNIFVALIIITFQEQGDKMMEECSLEKNERACIDFAISAKPLTRYMPQNRHTFQY 1459
Query: 3325 RVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKI 3504
RVW FV S +FEY I +I +NTV L K+Y + +E L N+ FT VF+ E VLK+
Sbjct: 1460 RVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKV 1519
Query: 3505 VALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSR 3684
+A NY D WN+FD + V+GS +I T +++F +LFR RL+KLL +
Sbjct: 1520 IAFGFVNYFRDTWNIFDFITVIGSITEIVLTDSKLVNTTGFNMSFLKLFRAARLIKLLRQ 1579
Query: 3685 GEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSF 3864
G IR LLWTF++SF+ALPYV LLI +LFFIYA+IGMQ FG + LD+ + I+R+NNF SF
Sbjct: 1580 GYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIRLDEESHINRHNNFRSF 1639
Query: 3865 PAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNES-RCGNNFAYPYFIS 4041
++++LFRSATGEAWQ+IMLSC + C+P D G ES RCG + AY YF+S
Sbjct: 1640 FGSLMLLFRSATGEAWQEIMLSCLGEKG--CEP--DTTAPSGQQESERCGTDLAYVYFVS 1695
Query: 4042 FFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVV 4221
F CSFL++NLFVAVIMDNF+YLTRD SILGPHHL+EFVR+W+EYD A GRI + ++
Sbjct: 1696 FIFFCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMY 1755
Query: 4222 TLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKI-YTEGN 4398
+L +SPPLG GK CP ++A KRLV MNMP+ D TV F +TL AL+RT L I +G
Sbjct: 1756 EMLTLMSPPLGLGKRCPSKVAYKRLVLMNMPVAEDMTVHFTSTLMALIRTALDIKIAKGG 1815
Query: 4399 ID--EANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKR 4572
D + + +L+ IW + +LD +V P K D+TVGK YA +I DY+++ K +
Sbjct: 1816 ADRQQLDSELQKETLAIWPHLSQKMLDLLV-PMPKASDLTVGKIYAAMMIMDYYKQSKVK 1874
Query: 4573 KE 4578
K+
Sbjct: 1875 KQ 1876
Score = 514 bits (1324), Expect = e-144
Identities = 285/667 (42%), Positives = 373/667 (55%), Gaps = 27/667 (4%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N +RK +++W PFE++IL I ANCI LA+ Q P D + LE E FI +
Sbjct: 75 DNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGI 134
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KIVA+GF+FH +YLRN WN++DFI+V+ G+++T + + D++ LRA R
Sbjct: 135 FCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTH-VDLRTLRAVR 193
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQ+VL +I++AM+PLL I LL+ F IL++AIIGLE + GKLH C
Sbjct: 194 VLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFV 253
Query: 760 PATGQLAQKDPT-PCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNF 936
+G L DP PCG + ++C+ W GPN+GIT FDN
Sbjct: 254 NNSGVLEGFDPPHPCGVQGCPAGYECKD------------------WIGPNDGITQFDNI 295
Query: 937 GLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFS 1116
A+LTVFQC+++EGWT V+Y NDA+G W W+YF+ L+I+GSFFVLNLVLGVLSGEF+
Sbjct: 296 LFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFA 355
Query: 1117 KEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNED---------------- 1248
KERE+ R F K R +QQ+E +L GY WI +AE++ E+
Sbjct: 356 KERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNSGTSALEVLRRATI 415
Query: 1249 ----------EQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXX 1398
+ DE + + +RL +++
Sbjct: 416 KRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGASYFRHKERLLRISVRHA--- 472
Query: 1399 XXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYS 1578
VKSQ FYW H+ Q +WL H A F+ LF +EM LKMY
Sbjct: 473 ---VKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYG 529
Query: 1579 LGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXX 1758
+G Y S FN FD V + SI E V F G+SVLR+ RLLRIFK+TKYW
Sbjct: 530 MGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASL 589
Query: 1759 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQAL 1938
GMQ+FGG+FNFN P ANFDTF A+
Sbjct: 590 RNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFN--DGTPSANFDTFPAAI 647
Query: 1939 LTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNL 2118
+TVFQILTGEDWN VMY+GI S GGV + G+ +Y+IVL + GNY LLNVFLAIAVDNL
Sbjct: 648 MTVFQILTGEDWNEVMYNGIRSQGGVSS-GMWSAVYFIVLTLFGNYTLLNVFLAIAVDNL 706
Query: 2119 ADADSLT 2139
A+A LT
Sbjct: 707 ANAQELT 713
Score = 126 bits (316), Expect = 7e-27
Identities = 96/351 (27%), Positives = 165/351 (46%), Gaps = 14/351 (3%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+NPIR+ C +V + FE IL +I A+ IALA P +N +L +YVF V
Sbjct: 1129 SNPIRRACHYVVNLRYFEMCILLVIAASSIALAAEDPVLTNSE--RNRVLRYFDYVFTGV 1186
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKM--SIQGFD---VKA 564
FT E V+K++ G + +Y R+ WNILDF++VV LV+ L+ + +G D +K+
Sbjct: 1187 FTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKS 1246
Query: 565 LRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLH 744
LR RVLRPL+ + +P L+ V + ++ ++ + +I ++ + I+A+I ++LF GK
Sbjct: 1247 LRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFF 1306
Query: 745 STCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITN 924
C D + DTE M V+ W +
Sbjct: 1307 -YCTDSS-------------KDTEKECIGNYVDHEKNKMEVK-----GREW---KRHEFH 1344
Query: 925 FDNFGLAMLTVFQCVSLEGWTDVMYWVNDAV---------GREWPWIYFVTLVILGSFFV 1077
+DN A+LT+F + EGW V+ D R I++V ++ FF
Sbjct: 1345 YDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFF 1404
Query: 1078 LNLVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDI 1230
+N+ + ++ F ++ + K E+ LE++ + +D+ A+ +
Sbjct: 1405 VNIFVALIIITFQEQGD---------KMMEECSLEKNERACIDFAISAKPL 1446
Score = 115 bits (289), Expect = 9e-24
Identities = 71/265 (26%), Positives = 134/265 (49%), Gaps = 4/265 (1%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V S+ F +++ ++ +NT +A H+ + L +F G+F E LK+ + P
Sbjct: 473 VKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGP 532
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD V VGS ++ + PG + I+ R R++R+ K+ +R
Sbjct: 533 RLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTS--FGISVLRALRLLRIFKITKYWASLR 590
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + M S +++ + L+ L ++A++GMQ F G+ +D T + NF +FPAAI
Sbjct: 591 NLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTP---SANFDTFPAAI 647
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLC 4056
+ +F+ TGE W ++M + +R +GG++ ++ YFI +
Sbjct: 648 MTVFQILTGEDWNEVMYN-----GIR--------SQGGVSSGM----WSAVYFIVLTLFG 690
Query: 4057 SFLVINLFVAVIMDNF---DYLTRD 4122
++ ++N+F+A+ +DN LT+D
Sbjct: 691 NYTLLNVFLAIAVDNLANAQELTKD 715
Score = 87.0 bits (214), Expect = 5e-15
Identities = 73/303 (24%), Positives = 133/303 (43%), Gaps = 21/303 (6%)
Frame = +1
Query: 268 FEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMF 447
FE+ I+ MI N + L + Y + Y+ L+ + F +VF++ECVLK++A GF+
Sbjct: 1470 FEYTIMAMIALNTVVLMM--KYYSAPCTYE-LALKYLNIAFTMVFSLECVLKVIAFGFV- 1525
Query: 448 HPSAYLRNAWNILDFIIVVIGLVSTILSKMSI---QGFDVKALRAFRVLRPLRLVSGVPS 618
Y R+ WNI DFI V+ + +L+ + GF++ L+ FR R ++L+ +
Sbjct: 1526 ---NYFRDTWNIFDFITVIGSITEIVLTDSKLVNTTGFNMSFLKLFRAARLIKLLRQGYT 1582
Query: 619 LQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTP 798
++++L +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1583 IRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF----------------------- 1619
Query: 799 CGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLE 978
N+ + E N +N +F FG ML +F+ + E
Sbjct: 1620 ------------------GNIRLDEESHINR-----HNNFRSF--FGSLML-LFRSATGE 1653
Query: 979 GWTDVM------------------YWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLS 1104
W ++M ++ G + ++YFV+ + SF +LNL + V+
Sbjct: 1654 AWQEIMLSCLGEKGCEPDTTAPSGQQESERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIM 1713
Query: 1105 GEF 1113
F
Sbjct: 1714 DNF 1716
Score = 85.5 bits (210), Expect = 1e-14
Identities = 78/346 (22%), Positives = 152/346 (43%), Gaps = 9/346 (2%)
Frame = +1
Query: 232 RKLCISI---VEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
R L IS+ V+ + F +++L ++ N +AI Q + LL E++F+ +F
Sbjct: 463 RLLRISVRHAVKSQVFYWIVLSLVALNTACVAIVHHNQPQ---WLTHLLYYAEFLFLGLF 519
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKALRAF 576
+E LK+ MG P Y +++N DF + V G + ++ + G F + LRA
Sbjct: 520 LLEMSLKMYGMG----PRLYFHSSFNCFDFGVTV-GSIFEVVWAIFRPGTSFGISVLRAL 574
Query: 577 RVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI 756
R+LR ++ SL+ ++ +++ +M ++ + L+ I+++A++G++LF G+ +
Sbjct: 575 RLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFN-- 632
Query: 757 DPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNF 936
D TP NFD F
Sbjct: 633 ----------DGTPSA---------------------------------------NFDTF 643
Query: 937 GLAMLTVFQCVSLEGWTDVMYWVNDAVG----REWPWIYFVTLVILGSFFVLNLVLGVLS 1104
A++TVFQ ++ E W +VMY + G W +YF+ L + G++ +LN+ L +
Sbjct: 644 PAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAVYFIVLTLFGNYTLLNVFLAIAV 703
Query: 1105 GEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVN 1242
+ Q+ + +Q EE+ + +A+++ P++
Sbjct: 704 DNLANA----------QELTKDEQEEEEAFNQKHALQKAKEVSPMS 739
Score = 80.5 bits (197), Expect = 4e-13
Identities = 106/484 (21%), Positives = 184/484 (37%), Gaps = 46/484 (9%)
Frame = +1
Query: 1534 FVILFSMEMLLKMYSLGFTTYTTSQF----NRFDCFVVISSILEFVLVY-FDLMKPLGVS 1698
F +F+ EM++KM G S F N D VV+ +++ F L K +
Sbjct: 1183 FTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIK 1242
Query: 1699 VLRSARLLRIF---KVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFG 1869
++S R+LR+ K K +Q+F
Sbjct: 1243 TIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFK 1302
Query: 1870 GKFNF---------------------NPQQPKPRA------NFDTFVQALLTVFQILTGE 1968
GKF + N + K R ++D + ALLT+F + TGE
Sbjct: 1303 GKFFYCTDSSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGE 1362
Query: 1969 DWNTVMYHGI----ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLAD-ADS 2133
W V+ H + E G + + + I+Y+V F+ + +N+F+A+ + + D
Sbjct: 1363 GWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDK 1422
Query: 2134 LTNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSARPRRMSEVPAASTVKP 2313
+ S + + A + KP
Sbjct: 1423 MMEE-------------------------------------CSLEKNERACIDFAISAKP 1445
Query: 2314 IPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMIL 2493
+ + HT +RV+ + VV+ S F ++ I +++ +L + A T + L
Sbjct: 1446 LTRYMPQ--NRHTFQYRVW-HFVVSPS-FEYTIMAMIALNTVVLMMK-YYSAPCTYELAL 1500
Query: 2494 NYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSX 2673
Y + FT VF++E LKVI FG V ++ R+ +N+ D + V S+T VL TD+
Sbjct: 1501 KYLNIAFTMVFSLECVLKVIAFGFV----NYFRDTWNIFDFITVIGSITEIVL-TDSKLV 1555
Query: 2674 XXXXXXXXXXXXXXAINRAKGLKH------VVQCVIVAVKTIGNIMLVTFMLQFMFAIIG 2835
A K L+ ++ + + K + + L+ ML F++AIIG
Sbjct: 1556 NTTGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIG 1615
Query: 2836 VQLF 2847
+Q+F
Sbjct: 1616 MQVF 1619
Score = 78.6 bits (192), Expect = 2e-12
Identities = 76/300 (25%), Positives = 125/300 (41%), Gaps = 28/300 (9%)
Frame = +1
Query: 2260 SARPRRMSEVPAASTV---KPIPKAS-------SLFILSHTNSFRVFCNMVVNHSYFTNA 2409
SA + S+ A T+ PIP SLFI N R + +++ F
Sbjct: 35 SAAAYKQSKAQRARTMALYNPIPVRQNCFTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYM 94
Query: 2410 VLFCILVSSAMLAAEDPLQANSTRNMI--LNYFDYFFTSVFTVEITLKVIVFGLVFHKGS 2583
+L I+ + +LA E L + M L + +F +F E +K++ G +FHKGS
Sbjct: 95 ILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIFHKGS 154
Query: 2584 FCRNAFNLLDILVV-----AVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHV 2748
+ RN +N++D +VV A + T F D + ++ L+ V
Sbjct: 155 YLRNGWNVMDFIVVLSGILATAGTHFNTHVDLRT----LRAVRVLRPLKLVSGIPSLQIV 210
Query: 2749 VQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYED 2928
++ ++ A+ + I L+ F MFAIIG++ + G K+ A E
Sbjct: 211 LKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSG---------KLHRACFVNNSGVLEG 261
Query: 2929 GDPTKPVS----------KKRVWSNNDF-NFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
DP P K + N+ FDN+ A++++F T EGW +LY D+
Sbjct: 262 FDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDA 321
Score = 77.8 bits (190), Expect = 3e-12
Identities = 75/303 (24%), Positives = 124/303 (40%), Gaps = 53/303 (17%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACKHY-------PSSRGFEDFLDVFNLIFTGVFAFEAVLKIVAL 3513
FEY+I I+ N + LA + + P SR E F G+F FEA +KIVAL
Sbjct: 91 FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT----EPYFIGIFCFEAGIKIVAL 146
Query: 3514 ----NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNL---ISINFFRLFRVMRLVK 3672
+ +Y+ + WNV D +VV+ G L GT+ + + R RV+R +K
Sbjct: 147 GFIFHKGSYLRNGWNVMDFIVVLS-------GILATAGTHFNTHVDLRTLRAVRVLRPLK 199
Query: 3673 LLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHR--- 3843
L+S ++ +L + MK+ L + LL+ ++A+IG++F+ S +HR
Sbjct: 200 LVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY-------SGKLHRACF 252
Query: 3844 -NNN-----------------------------------FHSFPAAILVLFRSATGEAWQ 3915
NN+ F + A+L +F+ T E W
Sbjct: 253 VNNSGVLEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWT 312
Query: 3916 DIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIM 4095
++ + +D G + + YFI ++ SF V+NL + V+
Sbjct: 313 TVLYNTND---------------------ALGATWNWLYFIPLIIIGSFFVLNLVLGVLS 351
Query: 4096 DNF 4104
F
Sbjct: 352 GEF 354
Score = 77.4 bits (189), Expect = 4e-12
Identities = 116/586 (19%), Positives = 203/586 (33%), Gaps = 71/586 (12%)
Frame = +1
Query: 1531 FFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVS 1698
+F+ +F E +K+ +LGF +Y + +N D VV+S IL +F+ L
Sbjct: 130 YFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDL--R 187
Query: 1699 VLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF 1878
LR+ R+LR K+ G++ + GK
Sbjct: 188 TLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKL 247
Query: 1879 N-------------FNPQQP-------------------KPRANFDTFVQALLTVFQILT 1962
+ F+P P FD + A+LTVFQ +T
Sbjct: 248 HRACFVNNSGVLEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCIT 307
Query: 1963 GEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLA------- 2121
E W TV+Y+ ++ G +Y+I L I G++ +LN+ L + A
Sbjct: 308 MEGWTTVLYNTNDALGATWNW-----LYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVE 362
Query: 2122 ------------DADSLTNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSA 2265
+ N T A
Sbjct: 363 NRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNSGTSALEVLRRATIKRSRTEA 422
Query: 2266 RPRRMSE---VPAASTVKPIPKAS--------SLFILSHTNSFRVFCNMVVNHSYFTNAV 2412
R S+ V +S P+ +AS + + R+ V F V
Sbjct: 423 MTRDSSDEHCVDISSVGTPLARASIKSAKVDGASYFRHKERLLRISVRHAVKSQVFYWIV 482
Query: 2413 LFCILVSSAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFG--LVFHKGSF 2586
L + +++A +A Q ++ L Y ++ F +F +E++LK+ G L FH
Sbjct: 483 LSLVALNTACVAIVHHNQPQWLTHL-LYYAEFLFLGLFLLEMSLKMYGMGPRLYFH---- 537
Query: 2587 CRNAFNLLDILVVAVSLTSFVLRTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQC 2757
++FN D V S+ V K L+++V
Sbjct: 538 --SSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVS 595
Query: 2758 VIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDP 2937
++ ++K+I +++ + F+ +FA++G+QLF G F ++ DG P
Sbjct: 596 LMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF-------------------NFNDGTP 636
Query: 2938 TKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDS 3075
+ NFD A++++F + T E W +++Y I S
Sbjct: 637 SA-------------NFDTFPAAIMTVFQILTGEDWNEVMYNGIRS 669
Score = 67.8 bits (164), Expect = 3e-09
Identities = 53/214 (24%), Positives = 86/214 (39%), Gaps = 17/214 (7%)
Frame = +1
Query: 1525 NLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLG--VS 1698
N+ F ++FS+E +LK+ + GF Y +N FD VI SI E VL L+ G +S
Sbjct: 1504 NIAFTMVFSLECVLKVIAFGFVNYFRDTWNIFDFITVIGSITEIVLTDSKLVNTTGFNMS 1563
Query: 1699 VLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF 1878
L+ R R+ K+ + GMQVFG
Sbjct: 1564 FLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIR 1623
Query: 1879 NFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMY---------------HGIESFGG 2013
NF +F +L+ +F+ TGE W +M G +
Sbjct: 1624 LDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQQESER 1683
Query: 2014 VGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDN 2115
GT + +Y++ ++++LN+F+A+ +DN
Sbjct: 1684 CGT--DLAYVYFVSFIFFCSFLMLNLFVAVIMDN 1715
>gi|348579|pir||A45386 omega-conotoxin-sensitive calcium channel
alpha-1 subunit rbB-I - rat
Length = 2336
Score = 660 bits (1703), Expect = 0.0
Identities = 353/788 (44%), Positives = 491/788 (61%), Gaps = 16/788 (2%)
Frame = +1
Query: 2308 KPIPKASSLF-ILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRN 2484
+PI SS+F LS TN R FC+ +V YF +L I +SS LAAEDP++ +S RN
Sbjct: 1119 RPIVPYSSMFGCLSPTNLLRRFCHYIVTMRYFEMVILVVIALSSIALAAEDPVRTDSFRN 1178
Query: 2485 MILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRT-- 2658
L Y DY FT VFT E+ +K+I GL+ H G++ R+ +N+LD +VV+ +L +F +
Sbjct: 1179 NALKYMDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSSFM 1238
Query: 2659 -----DAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
++ I R LK V CV+ ++K + NI++V + F+F
Sbjct: 1239 GGSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIF 1298
Query: 2824 AIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGD 3003
A+I VQLFKG FF C D SK E +CRG+Y+ YE + ++ R W DF++DNV
Sbjct: 1299 AVIAVQLFKGKFFYCTDESKELERDCRGQYLDYEKEEVE---AQPRQWKKYDFHYDNVLW 1355
Query: 3004 AMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXG 3183
A+++LF VST EGWP +L ++D+ E++GP R +++
Sbjct: 1356 ALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGFRMELSIFYVVYFVVFPFFFVNIFVA 1415
Query: 3184 FVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRAF 3357
+I+TFQ +G++ C L+KN+R CI+FA+ AKP RY+P+N+ QY+ W FV S F
Sbjct: 1416 LIIITFQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNKQSFQYKTWTFVVSPPF 1475
Query: 3358 EYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISD 3537
EY I +I +NTV L K Y + +E L N++FT +F+ E +LKI+A NY D
Sbjct: 1476 EYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSLECILKIIAFGVLNYFRD 1535
Query: 3538 RWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTF 3717
WNVFD + V+GS DI ++ N I+++F RLFR RL+KL +G IR LLWTF
Sbjct: 1536 AWNVFDFVTVLGSITDILVTEI---ANNFINLSFLRLFRAARLIKLCRQGYTIRILLWTF 1592
Query: 3718 MKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSA 3897
++SF+ALPYV LLI +LFFIYA+IGMQ FG +ALDD TSI+R+NNF +F A+++LFRSA
Sbjct: 1593 VQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDGTSINRHNNFRTFLQALMLLFRSA 1652
Query: 3898 TGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINL 4077
TGEAW +IMLSC CDP + N S CG++FAY YF+SF LCSFL++NL
Sbjct: 1653 TGEAWHEIMLSCLGNR--ACDPHA--------NASECGSDFAYFYFVSFIFLCSFLMLNL 1702
Query: 4078 FVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGF 4257
FVAVIMDNF+YLTRD SILGPHHL+EF+R+W+EYDP A GRI + D+ +L+ +SPPLG
Sbjct: 1703 FVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGL 1762
Query: 4258 GKLCPHRLACKRLVSMNMPL-NSDGTVCFNATLFALVRTNLKIY---TEGNIDEANEQLR 4425
GK CP R+A KRLV MNMP+ N D TV F +TL AL+RT L+I + + +LR
Sbjct: 1763 GKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALIRTALEIKLAPAGTKQHQCDAELR 1822
Query: 4426 SAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEM--EAKGVL 4599
I +W + LD +VPP K D++TVGK YA +I D++++ K ++ +A G L
Sbjct: 1823 KEISSVWANLPQKTLDLLVPP-HKPDEMTVGKVYAALMIFDFYKQNKTTRDQTHQAPGGL 1881
Query: 4600 PAQTPQAM 4623
P ++
Sbjct: 1882 SQMGPVSL 1889
Score = 506 bits (1304), Expect = e-141
Identities = 290/665 (43%), Positives = 373/665 (55%), Gaps = 25/665 (3%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N +RK I EW PFE++IL I ANCI LA+ Q P D + L+ E FI +
Sbjct: 81 DNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGI 140
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KI+A+GF+FH +YLRN WN++DF++V+ +++T + FD++ LRA R
Sbjct: 141 FCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTEILATAGTD-----FDLRTLRAVR 195
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQVVL +I++AM+PLL I LL+ F IL++AIIGLE + GK H C
Sbjct: 196 VLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFP 255
Query: 760 PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFG 939
+T D P G G + DS T EC WPGPN GITNFDN
Sbjct: 256 NST------DAEPVGDFPCGKEAPARLCDSDT------ECREY--WPGPNFGITNFDNIL 301
Query: 940 LAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSK 1119
A+LTVFQC+++EGWTD++Y NDA G W W+YF+ L+I+GSFF+LNLVLGVLSGEF+K
Sbjct: 302 FAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAK 361
Query: 1120 EREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDE--QEDEPVAQTXXXXX 1293
ERE+ R F R +QQ+E +L GYL+WI +AE++ ED+ +E P+
Sbjct: 362 ERERVENRRAFLNVRRQQQIERELNGYLEWIFKAEEVMLAEEDKNAEEKSPLDAVLKRAA 421
Query: 1294 XXXX-----------------------XXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXX 1404
++ ++ +R EK+
Sbjct: 422 TKKSRNDLIHAEEGEDRFVDLCAAGSPFARASLKSGKTESSSYFRRKEKM---FRFLIRR 478
Query: 1405 LVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLG 1584
+VK+Q+FYW HY Q + L A F+ LF EM LKMY LG
Sbjct: 479 MVKAQSFYWVVLCVVALNTLCVAMVHYNQPQRLTTALYFAEFVFLGLFLTEMSLKMYGLG 538
Query: 1585 FTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXX 1764
+Y S FN FD V++ SI E V G+SVLR+ RLLRIFKVTKYW
Sbjct: 539 PRSYFRSSFNCFDFGVIVGSIFEVVWAAIKPGTSFGISVLRALRLLRIFKVTKYWNSLRN 598
Query: 1765 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLT 1944
GMQ+FGG+FNF Q P NFDTF A+LT
Sbjct: 599 LVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF--QDETPTTNFDTFPAAILT 656
Query: 1945 VFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLAD 2124
VFQILTGEDWN VMYHGIES GGV + G+ Y+IVL + GNY LLNVFLAIAVDNLA+
Sbjct: 657 VFQILTGEDWNAVMYHGIESQGGV-SKGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLAN 715
Query: 2125 ADSLT 2139
A LT
Sbjct: 716 AQELT 720
Score = 134 bits (336), Expect = 3e-29
Identities = 94/326 (28%), Positives = 164/326 (49%), Gaps = 14/326 (4%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
N +R+ C IV + FE +IL +I + IALA P + ++N L+ ++Y+F VF
Sbjct: 1135 NLLRRFCHYIVTMRYFEMVILVVIALSSIALAAEDP--VRTDSFRNNALKYMDYIFTGVF 1192
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKM--SIQGFD---VKAL 567
T E V+K++ +G + HP AY R+ WNILDFI+V LV+ S +G D +K+L
Sbjct: 1193 TFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSSFMGGSKGKDINTIKSL 1252
Query: 568 RAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHS 747
R RVLRPL+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF GK
Sbjct: 1253 RVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF- 1311
Query: 748 TCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNF 927
C D + + ++D D E + QP +W+ ++
Sbjct: 1312 YCTDES--KELERDCRGQYLDYEKEEVEAQPR--------QWKKYD-----------FHY 1350
Query: 928 DNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWP---------WIYFVTLVILGSFFVL 1080
DN A+LT+F + EGW V+ DA E I++V ++ FF +
Sbjct: 1351 DNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGFRMELSIFYVVYFVVFPFFFV 1410
Query: 1081 NLVLGVLSGEFSKEREKARARGLFQK 1158
N+ + ++ F ++ +K + +K
Sbjct: 1411 NIFVALIIITFQEQGDKVMSECSLEK 1436
Score = 122 bits (305), Expect = 1e-25
Identities = 75/269 (27%), Positives = 136/269 (49%), Gaps = 8/269 (2%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V +++F +V+ ++ +NT+ +A HY + L +F G+F E LK+ L P
Sbjct: 480 VKAQSFYWVVLCVVALNTLCVAMVHYNQPQRLTTALYFAEFVFLGLFLTEMSLKMYGLGP 539
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
++Y +N FD V+VGS ++ + + PG + I+ R R++R+ K+ +R
Sbjct: 540 RSYFRSSFNCFDFGVIVGSIFEVVWAAIKPGTS--FGISVLRALRLLRIFKVTKYWNSLR 597
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + + S +++ + L+ L ++A++GMQ F G+ D T NF +FPAAI
Sbjct: 598 NLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETP---TTNFDTFPAAI 654
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYH----KGGLNESRCGNNFAYPYFISF 4044
L +F+ TGE W +M YH +GG+++ F+ YFI
Sbjct: 655 LTVFQILTGEDWNAVM-----------------YHGIESQGGVSKGM----FSSFYFIVL 693
Query: 4045 FMLCSFLVINLFVAVIMDNF---DYLTRD 4122
+ ++ ++N+F+A+ +DN LT+D
Sbjct: 694 TLFGNYTLLNVFLAIAVDNLANAQELTKD 722
Score = 97.4 bits (241), Expect = 3e-18
Identities = 72/295 (24%), Positives = 133/295 (44%), Gaps = 12/295 (4%)
Frame = +1
Query: 265 PFEFLILFMICANCIALAIYQPYPAQDSDYKNTL-LETIEYVFIVVFTIECVLKIVAMGF 441
PFE+ I+ MI N + L + D+ Y+ L L+ + VF +F++EC+LKI+A G
Sbjct: 1474 PFEYFIMAMIALNTVVLMM----KFYDAPYEYELMLKCLNIVFTSMFSLECILKIIAFGV 1529
Query: 442 MFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSL 621
+ Y R+AWN+ DF+ V+ + ++++++ ++ LR FR R ++L ++
Sbjct: 1530 L----NYFRDAWNVFDFVTVLGSITDILVTEIANNFINLSFLRLFRAARLIKLCRQGYTI 1585
Query: 622 QVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPC 801
+++L +++ L ++ LL+ + IYAIIG+++F G +A D T
Sbjct: 1586 RILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------GNIALDDGTSI 1632
Query: 802 GTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEG 981
N NF F A++ +F+ + E
Sbjct: 1633 ------------------------------------NRHNNFRTFLQALMLLFRSATGEA 1656
Query: 982 WTDVM-----------YWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
W ++M + G ++ + YFV+ + L SF +LNL + V+ F
Sbjct: 1657 WHEIMLSCLGNRACDPHANASECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1711
Score = 90.9 bits (224), Expect = 3e-16
Identities = 72/262 (27%), Positives = 118/262 (44%), Gaps = 13/262 (4%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLF+ S N R + + F +L I+ + +LA E L M L+
Sbjct: 74 SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 133
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV-----AVSLTSFVLRTDAM 2667
+ +F +F E +K+I G VFHKGS+ RN +N++D +VV A + T F LRT
Sbjct: 134 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTEILATAGTDFDLRT--- 190
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
++ L+ V++ ++ A+ + I L+ F MFAIIG++ +
Sbjct: 191 -----LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY 245
Query: 2848 KGTFFLCNDLSKMTEAECRGEYIHYEDGDP---TKPVSKKRVWSNNDF---NFDNVGDAM 3009
G F T+AE G++ ++ + W +F NFDN+ A+
Sbjct: 246 MGKFHKA-CFPNSTDAEPVGDFPCGKEAPARLCDSDTECREYWPGPNFGITNFDNILFAI 304
Query: 3010 ISLFVVSTFEGWPQLLYVAIDS 3075
+++F T EGW +LY D+
Sbjct: 305 LTVFQCITMEGWTDILYNTNDA 326
Score = 87.0 bits (214), Expect = 5e-15
Identities = 79/292 (27%), Positives = 126/292 (43%), Gaps = 42/292 (14%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY+I I+ N + LA + H P + LD F G+F FEA +KI+AL
Sbjct: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WNV D +VV+ L GT+ + R RV+R +KL+S
Sbjct: 157 HKGSYLRNGWNVMDFVVVLTEI-------LATAGTD-FDLRTLRAVRVLRPLKLVSGIPS 208
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF----------------------- 3804
++ +L + MK+ L + LL+ ++A+IG++F+
Sbjct: 209 LQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPC 268
Query: 3805 GKVA---LDDSTSIHRN---------NNFHSFPAAILVLFRSATGEAWQDIMLSCSDRED 3948
GK A L DS + R NF + AIL +F+ T E W DI+ + +D
Sbjct: 269 GKEAPARLCDSDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTND--- 325
Query: 3949 VRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
GN + + YFI ++ SF ++NL + V+ F
Sbjct: 326 ------------------AAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 359
Score = 70.5 bits (171), Expect = 5e-10
Identities = 53/204 (25%), Positives = 87/204 (41%), Gaps = 7/204 (3%)
Frame = +1
Query: 1525 NLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVL 1704
N+ F +FS+E +LK+ + G Y +N FD V+ SI + +LV + +S L
Sbjct: 1509 NIVFTSMFSLECILKIIAFGVLNYFRDAWNVFDFVTVLGSITD-ILVTEIANNFINLSFL 1567
Query: 1705 RSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNF 1884
R R R+ K+ + GMQVFG
Sbjct: 1568 RLFRAARLIKLCRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALD 1627
Query: 1885 NPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMY-----HGIESFGGVGTLGVIVCIYY 2049
+ NF TF+QAL+ +F+ TGE W+ +M + G +Y
Sbjct: 1628 DGTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLGNRACDPHANASECGSDFAYFY 1687
Query: 2050 IV--LFICGNYILLNVFLAIAVDN 2115
V +F+C ++++LN+F+A+ +DN
Sbjct: 1688 FVSFIFLC-SFLMLNLFVAVIMDN 1710
Score = 68.2 bits (165), Expect = 2e-09
Identities = 94/480 (19%), Positives = 182/480 (37%), Gaps = 42/480 (8%)
Frame = +1
Query: 1534 FVILFSMEMLLKMYSLGFTTYTTSQF----NRFDCFVVISSILEFVLVYF-DLMKPLGVS 1698
F +F+ EM++KM LG + + F N D VV +++ F F K ++
Sbjct: 1188 FTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSSFMGGSKGKDIN 1247
Query: 1699 VLRSARLLRIF---KVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFG 1869
++S R+LR+ K K +Q+F
Sbjct: 1248 TIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFK 1307
Query: 1870 GKFNFNPQQPK---------------------PRA------NFDTFVQALLTVFQILTGE 1968
GKF + + K PR ++D + ALLT+F + TGE
Sbjct: 1308 GKFFYCTDESKELERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGE 1367
Query: 1969 DWNTVMYHGI----ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSL 2136
W V+ H + E G + + I+Y+V F+ + +N+F+A+ + +
Sbjct: 1368 GWPMVLKHSVDATYEEQGPSPGFRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDK 1427
Query: 2137 TNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSARPRRMSEVPAASTVKPI 2316
+ S + + A + KP+
Sbjct: 1428 VMSE------------------------------------CSLEKNERACIDFAISAKPL 1451
Query: 2317 PKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMILN 2496
+ ++ + SF+ V F ++ I +++ +L + A ++L
Sbjct: 1452 TR----YMPQNKQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKF-YDAPYEYELMLK 1506
Query: 2497 YFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXX 2676
+ FTS+F++E LK+I FG++ ++ R+A+N+ D + V S+T +L T+ +
Sbjct: 1507 CLNIVFTSMFSLECILKIIAFGVL----NYFRDAWNVFDFVTVLGSITD-ILVTEIANNF 1561
Query: 2677 XXXXXXXXXXXXXAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
I + ++ ++ + + K + + L+ ML F++AIIG+Q+F
Sbjct: 1562 INLSFLRLFRAARLIKLCRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1621
Score = 54.7 bits (130), Expect = 3e-05
Identities = 55/264 (20%), Positives = 104/264 (38%), Gaps = 3/264 (1%)
Frame = +1
Query: 2293 AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN 2472
A +++K SS + FR +V F VL C++ + + A
Sbjct: 450 ARASLKSGKTESSSYFRRKEKMFRFLIRRMVKAQSFYWVVL-CVVALNTLCVAMVHYNQP 508
Query: 2473 STRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL 2652
L + ++ F +F E++LK+ G S+ R++FN D V+ S+ V
Sbjct: 509 QRLTTALYFAEFVFLGLFLTEMSLKMYGLG----PRSYFRSSFNCFDFGVIVGSIFEVVW 564
Query: 2653 RTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
K L+++V ++ ++K+I +++ + F+ +F
Sbjct: 565 AAIKPGTSFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVF 624
Query: 2824 AIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGD 3003
A++G+QLF G F +++D PT NFD
Sbjct: 625 ALLGMQLFGGQF-------------------NFQDETPTT-------------NFDTFPA 652
Query: 3004 AMISLFVVSTFEGWPQLLYVAIDS 3075
A++++F + T E W ++Y I+S
Sbjct: 653 AILTVFQILTGEDWNAVMYHGIES 676
>gi|5921698|sp|P56699|CCAE_DISOM Probable voltage-dependent R-type
calcium channel alpha-1E subunit (Voltage-gated calcium
channel alpha subunit Cav2.3) (DOE-1)
gi|476977|pir||A47447 calcium channel protein alpha-1 chain (variant
doe-1) - electric ray (Discopyge ommata)
Length = 2223
Score = 657 bits (1696), Expect = 0.0
Identities = 352/790 (44%), Positives = 487/790 (61%), Gaps = 14/790 (1%)
Frame = +1
Query: 2308 KPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNM 2487
K I +S+F+ TN R C+ +VN YF +L I SS LAAEDP+ +S RN
Sbjct: 1077 KAIIPYTSMFLFRKTNPIRRVCHFIVNLRYFEMCILLVIAASSVALAAEDPIHKDSARNQ 1136
Query: 2488 ILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRT--- 2658
+L YFDY FT VFT E+ +K+I GLVFH+GS+ R+ +N+LD +VV+ +L +F
Sbjct: 1137 VLRYFDYVFTGVFTFEMVIKMIDIGLVFHEGSYFRDVWNILDFIVVSGALVAFAFTNLIG 1196
Query: 2659 ----DAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFA 2826
++ I R LK V CV+ ++K + NI++V + F+FA
Sbjct: 1197 GSSGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFA 1256
Query: 2827 IIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNN--DFNFDNVG 3000
+I VQLFKG FF C D SKMT+ +CRG+++ Y +K + + N F++DNV
Sbjct: 1257 VIAVQLFKGKFFYCTDSSKMTKQDCRGQFVLYRQR------TKLSIENGNVTTFHYDNVV 1310
Query: 3001 DAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXX 3180
A+++LF VST EGWPQ+L ++D E D+GPI +R +++
Sbjct: 1311 WALLTLFTVSTGEGWPQVLQHSVDVTEADQGPIPGNRMEMSIFYIVYFVVFPFFFVNIFV 1370
Query: 3181 GFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRA 3354
+I+TFQ +G++ E L+KN+R CI+FA+ AKP RY+P+NR QYRVW FV S +
Sbjct: 1371 ALIIITFQEQGDKMLEESSLEKNERACIDFAISAKPLTRYMPQNRQTFQYRVWQFVVSPS 1430
Query: 3355 FEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYIS 3534
FEY I +I +NTV L KH+ GF L + N+ FT F E +LKI+A NY
Sbjct: 1431 FEYTILTMIALNTVVLMMKHHSPPPGFASVLKLMNIAFTITFTLECILKIIAFGFLNYFR 1490
Query: 3535 DRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWT 3714
D WNVFD + VVGS +I + N ++++F +LFR RL+KLL +G IR LLWT
Sbjct: 1491 DSWNVFDFVTVVGSISEIIVTECN---LKFVNLSFLKLFRAARLIKLLRQGITIRILLWT 1547
Query: 3715 FMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRS 3894
F++SF+ALPYV LLI +LFFIYA+IGMQ FG + LDD T I+R+NNFH+F A+++LFRS
Sbjct: 1548 FVQSFKALPYVCLLIAMLFFIYAIIGMQLFGNIGLDDHTPINRHNNFHTFFNALMLLFRS 1607
Query: 3895 ATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVIN 4074
ATGE+WQ+IML+C ++ C+ G E CG + AY YF+SF LCSFL++N
Sbjct: 1608 ATGESWQEIMLACLSGKE--CE---------GTREPSCGTDVAYFYFVSFIFLCSFLMLN 1656
Query: 4075 LFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLG 4254
LFVAVIMDNF+YLTRD SILGPHHL+EFVR+W+EYD A GRI + D+ +L +SPPLG
Sbjct: 1657 LFVAVIMDNFEYLTRDSSILGPHHLDEFVRVWAEYDRAACGRIHYTDMYQMLTLMSPPLG 1716
Query: 4255 FGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKI-YTEGNID--EANEQLR 4425
GK CP ++A KRLV MNMP+ D TV F +TL L+RT L+I G D + + +LR
Sbjct: 1717 LGKKCPSKVAYKRLVLMNMPVTEDKTVHFTSTLMGLIRTALQIKLARGGADKQQLDAELR 1776
Query: 4426 SAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEMEAKGVLPA 4605
I IW + LD +V P D+TVGK YA +I DY+++ K +K + + +
Sbjct: 1777 KEIMTIWPHLSQKTLDLLV-PMHTYSDLTVGKIYAAMMIMDYYKQSKNKKYQKLQEE-QS 1834
Query: 4606 QTPQAMALQA 4635
+TP ++A
Sbjct: 1835 RTPMFQRMEA 1844
Score = 506 bits (1303), Expect = e-141
Identities = 289/670 (43%), Positives = 380/670 (56%), Gaps = 30/670 (4%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N +RK ++EW PFE++IL I ANC+ LA+ Q P D LE E FI +
Sbjct: 88 DNIVRKSARRVIEWPPFEYMILATIIANCVVLALEQHLPNGDKTPMAKSLEQTEPYFIGI 147
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KIVA+GF+FH +YLRN WN++DFI+V+ GL++T + F+++ LRA R
Sbjct: 148 FCFEAGIKIVALGFVFHKGSYLRNGWNVMDFIVVLSGLLATAATH-----FNLRTLRAVR 202
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI- 756
VLRPL+LVSG+PSLQ+VL +I++AM+PLL I LL+ F IL++AIIGLE + GKLH TC
Sbjct: 203 VLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYYGKLHRTCYT 262
Query: 757 -DPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDN 933
D A +L + PCGT +P+ N V CS W GPN+GIT FDN
Sbjct: 263 DDAAAEELDLQ--FPCGTQ--------EPTRLCPNGTV---CSY---WIGPNDGITQFDN 306
Query: 934 FGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
A+LTVFQC+++EGWT ++Y +DA+G W W+YF+ L+I+GSFFVLNLVLGVLSGEF
Sbjct: 307 ILFALLTVFQCITMEGWTTILYNTDDALGAMWNWLYFIPLIIIGSFFVLNLVLGVLSGEF 366
Query: 1114 SKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDI--------------------- 1230
+KERE+ R F K R +QQ+E +L GY WI +AE++
Sbjct: 367 AKERERVENRRSFLKLRRQQQIERELNGYRAWIDKAEEVMLLEENKNAGEKSALHVLRRA 426
Query: 1231 -------EPVNEDEQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXX 1389
E + + ED+ + S + R +R+ +++
Sbjct: 427 TIKKGRMEMIQTESSEDQYTEISSVGSPLARASIKSTKLLEGSSYFRRKERMLRISIRH- 485
Query: 1390 XXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLK 1569
+VKS FYW HY Q WL +F A F+ LFS EM LK
Sbjct: 486 -----MVKSHAFYWIVLGLVALNTVCVAVVHYDQPLWLSNFLYYAEFTFLGLFSSEMFLK 540
Query: 1570 MYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYW 1749
MY G Y S FN FDC V+I SI + V G+SVLR+ RLLRIFK+TKYW
Sbjct: 541 MYGCGPRLYFHSSFNCFDCGVIIGSIFDVVWTIIRPETSFGISVLRALRLLRIFKITKYW 600
Query: 1750 TXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFV 1929
GMQ+FGG+FNF ++ P NFDTF
Sbjct: 601 ASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF--EEGTPPTNFDTFP 658
Query: 1930 QALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
A++TVFQILTGEDWN VMY+GI+S GGV + G+ +Y+IVL + GNY LLNVFLAIAV
Sbjct: 659 AAIITVFQILTGEDWNEVMYNGIKSQGGVNS-GMWSSVYFIVLTLFGNYTLLNVFLAIAV 717
Query: 2110 DNLADADSLT 2139
DNLA+A LT
Sbjct: 718 DNLANAQELT 727
Score = 183 bits (465), Expect = 4e-44
Identities = 161/657 (24%), Positives = 272/657 (40%), Gaps = 26/657 (3%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NPIR++C IV + FE IL +I A+ +ALA P + +N +L +YVF VF
Sbjct: 1092 NPIRRVCHFIVNLRYFEMCILLVIAASSVALAAEDPIHKDSA--RNQVLRYFDYVFTGVF 1149
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKM--SIQGFD---VKAL 567
T E V+K++ +G +FH +Y R+ WNILDFI+V LV+ + + G D +K+L
Sbjct: 1150 TFEMVIKMIDIGLVFHEGSYFRDVWNILDFIVVSGALVAFAFTNLIGGSSGKDINTIKSL 1209
Query: 568 RAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHS 747
R RVLRPL+ + +P L+ V + ++ ++ + +I ++ + I+A+I ++LF GK
Sbjct: 1210 RVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKF-- 1267
Query: 748 TCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWE---CSSNTTWPGPNNGI 918
F C S +T R + T N +
Sbjct: 1268 --------------------------FYCTDSSKMTKQDCRGQFVLYRQRTKLSIENGNV 1301
Query: 919 TNF--DNFGLAMLTVFQCVSLEGWTDVMYWVNDAV---------GREWPWIYFVTLVILG 1065
T F DN A+LT+F + EGW V+ D R I+++ ++
Sbjct: 1302 TTFHYDNVVWALLTLFTVSTGEGWPQVLQHSVDVTEADQGPIPGNRMEMSIFYIVYFVVF 1361
Query: 1066 SFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNE 1245
FF +N+ + ++ F ++ + K E+ LE++ + +D+ A +P+
Sbjct: 1362 PFFFVNIFVALIIITFQEQGD---------KMLEESSLEKNERACIDFAISA---KPLTR 1409
Query: 1246 DEQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTF 1425
++ Q W V S +F
Sbjct: 1410 YMPQNRQTFQYRV-------------------W-------------------QFVVSPSF 1431
Query: 1426 YWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTS 1605
+ +H+ + N+ F I F++E +LK+ + GF Y
Sbjct: 1432 EYTILTMIALNTVVLMMKHHSPPPGFASVLKLMNIAFTITFTLECILKIIAFGFLNYFRD 1491
Query: 1606 QFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXX 1785
+N FD V+ SI E ++ +L K + +S L+ R R+ K+ +
Sbjct: 1492 SWNVFDFVTVVGSISEIIVTECNL-KFVNLSFLKLFRAARLIKLLRQGITIRILLWTFVQ 1550
Query: 1786 XXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPR-ANFDTFVQALLTVFQILT 1962
GMQ+F G + P R NF TF AL+ +F+ T
Sbjct: 1551 SFKALPYVCLLIAMLFFIYAIIGMQLF-GNIGLDDHTPINRHNNFHTFFNALMLLFRSAT 1609
Query: 1963 GEDWNTVMYHGIESFGGVGT----LGVIVCIYYIV--LFICGNYILLNVFLAIAVDN 2115
GE W +M + GT G V +Y V +F+C ++++LN+F+A+ +DN
Sbjct: 1610 GESWQEIMLACLSGKECEGTREPSCGTDVAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1665
Score = 119 bits (297), Expect = 1e-24
Identities = 71/263 (26%), Positives = 131/263 (48%), Gaps = 1/263 (0%)
Frame = +1
Query: 3316 LQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAV 3495
L+ + V S AF +++ ++ +NTV +A HY +FL F G+F+ E
Sbjct: 479 LRISIRHMVKSHAFYWIVLGLVALNTVCVAVVHYDQPLWLSNFLYYAEFTFLGLFSSEMF 538
Query: 3496 LKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKL 3675
LK+ P+ Y +N FD V++GS D+ + + P I+ R R++R+ K+
Sbjct: 539 LKMYGCGPRLYFHSSFNCFDCGVIIGSIFDVVWTIIRP--ETSFGISVLRALRLLRIFKI 596
Query: 3676 LSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNN 3852
+R L+ + M S +++ + L+ L ++A++GMQ F G+ ++ T N
Sbjct: 597 TKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFEEGTP---PTN 653
Query: 3853 FHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPY 4032
F +FPAAI+ +F+ TGE W ++M + + GG+N ++ Y
Sbjct: 654 FDTFPAAIITVFQILTGEDWNEVMYNGIKSQ-------------GGVNSGM----WSSVY 696
Query: 4033 FISFFMLCSFLVINLFVAVIMDN 4101
FI + ++ ++N+F+A+ +DN
Sbjct: 697 FIVLTLFGNYTLLNVFLAIAVDN 719
Score = 102 bits (255), Expect = 8e-20
Identities = 74/294 (25%), Positives = 133/294 (45%), Gaps = 12/294 (4%)
Frame = +1
Query: 268 FEFLILFMICANCIALAI--YQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGF 441
FE+ IL MI N + L + + P P S +L+ + F + FT+EC+LKI+A GF
Sbjct: 1431 FEYTILTMIALNTVVLMMKHHSPPPGFAS-----VLKLMNIAFTITFTLECILKIIAFGF 1485
Query: 442 MFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSL 621
+ Y R++WN+ DF+ VV + I+++ +++ ++ L+ FR R ++L+ ++
Sbjct: 1486 L----NYFRDSWNVFDFVTVVGSISEIIVTECNLKFVNLSFLKLFRAARLIKLLRQGITI 1541
Query: 622 QVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPC 801
+++L +++ L ++ LL+ + IYAIIG++LF G + D TP
Sbjct: 1542 RILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQLF-------------GNIGLDDHTPI 1588
Query: 802 GTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEG 981
N NF F A++ +F+ + E
Sbjct: 1589 ------------------------------------NRHNNFHTFFNALMLLFRSATGES 1612
Query: 982 WTDVMYWV----------NDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
W ++M + G + + YFV+ + L SF +LNL + V+ F
Sbjct: 1613 WQEIMLACLSGKECEGTREPSCGTDVAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1666
Score = 80.9 bits (198), Expect = 3e-13
Identities = 71/264 (26%), Positives = 115/264 (42%), Gaps = 15/264 (5%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLF+ N R V+ F +L I+ + +LA E L M L
Sbjct: 81 SLFLFGEDNIVRKSARRVIEWPPFEYMILATIIANCVVLALEQHLPNGDKTPMAKSLEQT 140
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV-----AVSLTSFVLRTDAM 2667
+ +F +F E +K++ G VFHKGS+ RN +N++D +VV A + T F LRT
Sbjct: 141 EPYFIGIFCFEAGIKIVALGFVFHKGSYLRNGWNVMDFIVVLSGLLATAATHFNLRT--- 197
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
++ L+ V++ ++ A+ + I L+ F MFAIIG++ +
Sbjct: 198 -----LRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY 252
Query: 2848 KGTFFLCNDLSKMTEAECRGEYIHYEDG--DPTKPVSKKRVWS----NND--FNFDNVGD 3003
G + +A + + G +PT+ V S ND FDN+
Sbjct: 253 YGKL---HRTCYTDDAAAEELDLQFPCGTQEPTRLCPNGTVCSYWIGPNDGITQFDNILF 309
Query: 3004 AMISLFVVSTFEGWPQLLYVAIDS 3075
A++++F T EGW +LY D+
Sbjct: 310 ALLTVFQCITMEGWTTILYNTDDA 333
Score = 75.5 bits (184), Expect = 1e-11
Identities = 74/292 (25%), Positives = 123/292 (41%), Gaps = 42/292 (14%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY+I I+ N V LA + H P+ L+ F G+F FEA +KIVAL
Sbjct: 104 FEYMILATIIANCVVLALEQHLPNGDKTPMAKSLEQTEPYFIGIFCFEAGIKIVALGFVF 163
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WNV D +VV+ G L T+ ++ R RV+R +KL+S
Sbjct: 164 HKGSYLRNGWNVMDFIVVLS-------GLLATAATH-FNLRTLRAVRVLRPLKLVSGIPS 215
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQF-FGKV----ALDDSTSIHRN---- 3846
++ +L + MK+ L + LL+ ++A+IG++F +GK+ DD+ + +
Sbjct: 216 LQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYYGKLHRTCYTDDAAAEELDLQFP 275
Query: 3847 --------------------------NNFHSFPAAILVLFRSATGEAWQDIMLSCSDRED 3948
F + A+L +F+ T E W I+ + D
Sbjct: 276 CGTQEPTRLCPNGTVCSYWIGPNDGITQFDNILFALLTVFQCITMEGWTTILYNTDD--- 332
Query: 3949 VRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
G + + YFI ++ SF V+NL + V+ F
Sbjct: 333 ------------------ALGAMWNWLYFIPLIIIGSFFVLNLVLGVLSGEF 366
Score = 50.8 bits (120), Expect = 4e-04
Identities = 54/241 (22%), Positives = 104/241 (42%), Gaps = 7/241 (2%)
Frame = +1
Query: 2374 NMVVNHSYFTNAVLFCIL--VSSAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLK 2547
+MV +H+++ + L V A++ + PL ++ L Y ++ F +F+ E+ LK
Sbjct: 485 HMVKSHAFYWIVLGLVALNTVCVAVVHYDQPLWLSN----FLYYAEFTFLGLFSSEMFLK 540
Query: 2548 VIVFG--LVFHKGSFCRNAFNLLDILVVAVSLTSFV---LRTDAMSXXXXXXXXXXXXXX 2712
+ G L FH ++FN D V+ S+ V +R +
Sbjct: 541 MYGCGPRLYFH------SSFNCFDCGVIIGSIFDVVWTIIRPETSFGISVLRALRLLRIF 594
Query: 2713 XAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTE 2892
L+++V ++ ++K+I +++ + F+ +FA++G+QLF G F
Sbjct: 595 KITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGQF----------- 643
Query: 2893 AECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAID 3072
++E+G P NFD A+I++F + T E W +++Y I
Sbjct: 644 --------NFEEGTPPT-------------NFDTFPAAIITVFQILTGEDWNEVMYNGIK 682
Query: 3073 S 3075
S
Sbjct: 683 S 683
>gi|32478671|gb|AAP83588.1| neuronal-type voltage-gated calcium
channel subunit Cav2.2 [Oncorhynchus mykiss]
Length = 2365
Score = 646 bits (1667), Expect = 0.0
Identities = 382/1001 (38%), Positives = 551/1001 (54%), Gaps = 42/1001 (4%)
Frame = +1
Query: 2308 KPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNM 2487
K I SS+F+ TN R C+ VVN YF +L I +SS LAAEDP+QAN+ RN
Sbjct: 1103 KHILPYSSMFVFGQTNPVRRLCHYVVNLRYFEMCILSVITMSSIALAAEDPVQANAPRNN 1162
Query: 2488 ILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL---RT 2658
+L Y DY FT VFT E+ +K+I GL+ H GS+ R+ +N+LD +VV+ +L +F +
Sbjct: 1163 VLKYLDYVFTGVFTFEMVIKMIDLGLLLHPGSYFRDLWNILDFIVVSGALVAFACSGTKG 1222
Query: 2659 DAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGV 2838
++ I R LK V CV+ ++K + NI++V + F+FA+I V
Sbjct: 1223 KDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAV 1282
Query: 2839 QLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISL 3018
QLFKG FF C D SK E +CRG+++ Y DGD ++ R W +F++DNV A ++L
Sbjct: 1283 QLFKGKFFYCTDESKGLEKDCRGKFLDY-DGDEV--AAQDREWRKYEFHYDNVLWAFLTL 1339
Query: 3019 FVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIVT 3198
F VST EGWP +L ++D+ ED+GP R ++ +I+T
Sbjct: 1340 FTVSTGEGWPMVLKHSVDATYEDEGPSPGFRMETSIFYVVYFVVFPFFFVNIFVALIIIT 1399
Query: 3199 FQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRAFEY--- 3363
FQ +G++ C L+KN+R CI+FA+ AKP RY+P ++ QY++W FV S FEY
Sbjct: 1400 FQEQGDKAMSECSLEKNERACIDFAINAKPLTRYMPADKQSFQYKMWQFVVSPPFEYSIM 1459
Query: 3364 -VIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDR 3540
+I +I +NTV L K + + +E L N++FT +F E +LKI+A P NY+
Sbjct: 1460 TMIMTMIALNTVVLMMKFHGAPELYEAMLKHLNIVFTALFTLECILKIIAFGPLNYLKAA 1519
Query: 3541 WNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFM 3720
WNVFD + V+GS DI ++ LI+++F RLFR RL+KLL +G IR LLWTF+
Sbjct: 1520 WNVFDFVTVLGSITDILVTEIKTD--KLINLSFLRLFRAARLIKLLRQGYTIRILLWTFV 1577
Query: 3721 KSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSAT 3900
+SF+ LPYV LLI +LFFIYA+IGMQ FG + L++ T+I+ +NNF +F A+++LFRSAT
Sbjct: 1578 QSFKGLPYVCLLIAMLFFIYAIIGMQVFGNIELNEETAINPHNNFRTFFQALMLLFRSAT 1637
Query: 3901 GEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLF 4080
GEAW +IMLSC CD +S G CG++FAY YF+SF LCSFL++NLF
Sbjct: 1638 GEAWHEIMLSCLSNRP--CDKLS------GSGGKECGSDFAYFYFVSFIFLCSFLMLNLF 1689
Query: 4081 VAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFG 4260
VAVIMDNF+YLTRD SILGPHHL+EF+R+W+EYDP A GR+ +LD+ +LR +SPPLG G
Sbjct: 1690 VAVIMDNFEYLTRDASILGPHHLDEFIRVWAEYDPAACGRMTYLDMYEMLRHMSPPLGLG 1749
Query: 4261 KLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNI---DEANEQLRSA 4431
K CP R+A KRLV MNMP+ D TV F +TL AL+RT L+I + + LR
Sbjct: 1750 KKCPPRIAYKRLVKMNMPIADDNTVHFTSTLMALIRTALEIKLASGVLAQRLCDADLRKE 1809
Query: 4432 IKRIWKRTHKDLLDEVVPPAGKED-------------DVTVGKFYATFLIQDYFRRFKKR 4572
I R+W + +D +V P ++ ++TVGK YA +I DY+++ + +
Sbjct: 1810 ISRVWPNLPQKTIDLLVTPYKNDEFNELLCPFAVVNRELTVGKVYAALMIFDYYKQNRAK 1869
Query: 4573 KEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDEPEPQHR-RPHS 4749
+ + G+ T + A R + + + + +PEP+ + P
Sbjct: 1870 RLEQQLGLDFTGTIKNKKGPAFFRPMMPMTHMQEEGTTVAGANPLPSSQPEPESQPEPTP 1929
Query: 4750 LFNNLVHRLSGAGSKSPTEHERIEKGSTLLPFQPRSFSPTHSLAGAEGSPVP-------- 4905
+L + + ++SP + E G L RS S L + VP
Sbjct: 1930 STTSLTNGEAVPSTRSPIK----ESGEQLSQEGQRSSSRKRILQRGQSEDVPYSNKPQES 1985
Query: 4906 ---SQMHRGAPINQSINLPPVNGSARRLPALPPYANHIHDETDDGPRYRDTGDRAGYDQS 5076
Q+ GA I L +G A +P L N H G D + +S
Sbjct: 1986 VEMRQVENGADIGGYSGLDG-HGRAASMPRLDSQYNRTHPRHRPGSYLAPIADISPIRRS 2044
Query: 5077 SRMVVA--NRNLPV---DPDEEEQWMRSGGPSNRSDRRNPH 5184
+ + + +R + + + Q S P DR + H
Sbjct: 2045 ASTLASQCHREMSLRVYTLERPSQAQASSAPGQAQDRPHHH 2085
Score = 512 bits (1318), Expect = e-143
Identities = 291/664 (43%), Positives = 379/664 (56%), Gaps = 27/664 (4%)
Frame = +1
Query: 229 IRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTI 408
IRK I EW PFE+LIL I ANCI LA+ Q PA D + L+ E FI +F
Sbjct: 76 IRKYAKKITEWPPFEYLILATIIANCIVLALEQHLPASDKTPMSERLDDTEPYFIAIFCF 135
Query: 409 ECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLR 588
E +KI+A+GF FH +YLRN WN++DF++V+ G+++T+ + FD++ LRA RVLR
Sbjct: 136 EAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGMLATVGAD-----FDLRTLRAVRVLR 190
Query: 589 PLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPAT 768
PL+LVSG+PSLQVVL +I++AM+PLL I +L+ F IL++AIIGL+ + GK H TC T
Sbjct: 191 PLKLVSGIPSLQVVLKSIMKAMVPLLQIGMLLFFAILMFAIIGLDFYMGKFHRTCFRTDT 250
Query: 769 GQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAM 948
G+ A + PCG + P+ + N V E W GP GITNFDN A+
Sbjct: 251 GEQAAE--FPCGLEA--------PARTCENGTVCQEY-----WIGPTYGITNFDNILFAV 295
Query: 949 LTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKERE 1128
L+VFQC+++EGW D++Y NDA G W W+YF+ L+I+GSFF+LNLVLGVLSGEF+KERE
Sbjct: 296 LSVFQCITMEGWVDILYNANDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERE 355
Query: 1129 KARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEP-------------- 1266
+ R F K R +QQ+E +L GYL+WI +AE++ EDE +E
Sbjct: 356 RVEKRQDFLKLRRQQQIERELTGYLEWICKAEEVLLEEEDENAEEKSPLDVLKRGKVKKS 415
Query: 1267 ----VAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLE------KLNXXXXXXXXXLVKS 1416
+ + + + +LE + +VK+
Sbjct: 416 KNDLIGAEEGEDHFTDMSSVAPPGSPFGRASVKSSKLESSSYFRRKERRMRFFIRRMVKA 475
Query: 1417 QTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTY 1596
Q+FYW HY Q EWL +A F+ LF EM LKMY LG Y
Sbjct: 476 QSFYWIVLCLVGLNTLCVAIVHYDQPEWLTTGLYLAEFVFLGLFLSEMSLKMYGLGARNY 535
Query: 1597 TTSQFNRFDCFVVISSILEFVLVYFDLMKP---LGVSVLRSARLLRIFKVTKYWTXXXXX 1767
S FN FD V+I SILE V + ++KP G+SVLR+ RLLR+FK TKYW
Sbjct: 536 FHSSFNCFDFSVIIGSILE---VVWSMIKPGASYGISVLRALRLLRLFKFTKYWNSLRNL 592
Query: 1768 XXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTV 1947
GMQ+FGG+FNF ++ P NFDTF A+LTV
Sbjct: 593 VVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF--EEETPTTNFDTFPAAILTV 650
Query: 1948 FQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADA 2127
FQILTGEDWN VMYHGIES GGV G+ +Y+IVL + GNY LLNVFLAIAVDNLA+A
Sbjct: 651 FQILTGEDWNAVMYHGIESQGGV-RRGMFSSVYFIVLTLFGNYTLLNVFLAIAVDNLANA 709
Query: 2128 DSLT 2139
LT
Sbjct: 710 QELT 713
Score = 138 bits (348), Expect = 1e-30
Identities = 98/324 (30%), Positives = 163/324 (50%), Gaps = 12/324 (3%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+R+LC +V + FE IL +I + IALA P A +N +L+ ++YVF VF
Sbjct: 1118 NPVRRLCHYVVNLRYFEMCILSVITMSSIALAAEDPVQANAP--RNNVLKYLDYVFTGVF 1175
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD---VKALRA 573
T E V+K++ +G + HP +Y R+ WNILDFI+V LV+ S +G D +K+LR
Sbjct: 1176 TFEMVIKMIDLGLLLHPGSYFRDLWNILDFIVVSGALVAFACS--GTKGKDINTIKSLRV 1233
Query: 574 FRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTC 753
RVLRPL+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF GK C
Sbjct: 1234 LRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF-YC 1292
Query: 754 IDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDN 933
D + G +KD D +G Q + W ++DN
Sbjct: 1293 TDESKG--LEKDCRGKFLDYDGDEVAAQDRE--------WRKYE-----------FHYDN 1331
Query: 934 FGLAMLTVFQCVSLEGWTDVMYWVNDAV---------GREWPWIYFVTLVILGSFFVLNL 1086
A LT+F + EGW V+ DA R I++V ++ FF +N+
Sbjct: 1332 VLWAFLTLFTVSTGEGWPMVLKHSVDATYEDEGPSPGFRMETSIFYVVYFVVFPFFFVNI 1391
Query: 1087 VLGVLSGEFSKEREKARARGLFQK 1158
+ ++ F ++ +KA + +K
Sbjct: 1392 FVALIIITFQEQGDKAMSECSLEK 1415
Score = 123 bits (308), Expect = 6e-26
Identities = 75/278 (26%), Positives = 140/278 (49%), Gaps = 8/278 (2%)
Frame = +1
Query: 3313 RLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEA 3492
R+++ + V +++F +++ ++ +NT+ +A HY L + +F G+F E
Sbjct: 464 RMRFFIRRMVKAQSFYWIVLCLVGLNTLCVAIVHYDQPEWLTTGLYLAEFVFLGLFLSEM 523
Query: 3493 VLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVK 3672
LK+ L +NY +N FD V++GS +++ + + PG + IS+ R R++RL K
Sbjct: 524 SLKMYGLGARNYFHSSFNCFDFSVIIGSILEVVWSMIKPGASYGISV--LRALRLLRLFK 581
Query: 3673 LLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNN 3849
+R L+ + + S +++ + L+ L ++A++GMQ F G+ ++ T
Sbjct: 582 FTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFEEETP---TT 638
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYH----KGGLNESRCGNN 4017
NF +FPAAIL +F+ TGE W +M YH +GG+
Sbjct: 639 NFDTFPAAILTVFQILTGEDWNAVM-----------------YHGIESQGGVRRGM---- 677
Query: 4018 FAYPYFISFFMLCSFLVINLFVAVIMDNF---DYLTRD 4122
F+ YFI + ++ ++N+F+A+ +DN LT+D
Sbjct: 678 FSSVYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 715
Score = 89.0 bits (219), Expect = 1e-15
Identities = 74/336 (22%), Positives = 149/336 (44%), Gaps = 5/336 (1%)
Frame = +1
Query: 250 IVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIV 429
+V+ + F +++L ++ N + +AI ++ T L E+VF+ +F E LK+
Sbjct: 472 MVKAQSFYWIVLCLVGLNTLCVAIVH---YDQPEWLTTGLYLAEFVFLGLFLSEMSLKMY 528
Query: 430 AMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSI-QGFDVKALRAFRVLRPLRLVS 606
+G Y +++N DF +++ ++ + S + + + LRA R+LR +
Sbjct: 529 GLG----ARNYFHSSFNCFDFSVIIGSILEVVWSMIKPGASYGISVLRALRLLRLFKFTK 584
Query: 607 GVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQK 786
SL+ ++ ++L +M ++ + L+ I+++A++G++LF G+ + ++
Sbjct: 585 YWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFN----------FEEE 634
Query: 787 DPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQC 966
PT TNFD F A+LTVFQ
Sbjct: 635 TPT-----------------------------------------TNFDTFPAAILTVFQI 653
Query: 967 VSLEGWTDVMYWVNDAVG----REWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKA 1134
++ E W VMY ++ G + +YF+ L + G++ +LN+ L + + +E
Sbjct: 654 LTGEDWNAVMYHGIESQGGVRRGMFSSVYFIVLTLFGNYTLLNVFLAIAVDNLANAQE-- 711
Query: 1135 RARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVN 1242
K EKQ+ E + K L + +++ PV+
Sbjct: 712 -----LTKDEEKQEEEANKKLALQKAMEVKEVSPVS 742
Score = 88.2 bits (217), Expect = 2e-15
Identities = 72/302 (23%), Positives = 135/302 (43%), Gaps = 19/302 (6%)
Frame = +1
Query: 265 PFEF----LILFMICANCIALAI-YQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIV 429
PFE+ +I+ MI N + L + + P + +L+ + VF +FT+EC+LKI+
Sbjct: 1453 PFEYSIMTMIMTMIALNTVVLMMKFHGAP----ELYEAMLKHLNIVFTALFTLECILKII 1508
Query: 430 AMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGF-DVKALRAFRVLRPLRLVS 606
A G P YL+ AWN+ DF+ V+ + +++++ ++ LR FR R ++L+
Sbjct: 1509 AFG----PLNYLKAAWNVFDFVTVLGSITDILVTEIKTDKLINLSFLRLFRAARLIKLLR 1564
Query: 607 GVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQK 786
+++++L +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1565 QGYTIRILLWTFVQSFKGLPYVCLLIAMLFFIYAIIGMQVF------------------- 1605
Query: 787 DPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQC 966
N+ + E + N P+N NF F A++ +F+
Sbjct: 1606 ----------------------GNIELNEETAIN-----PHN---NFRTFFQALMLLFRS 1635
Query: 967 VSLEGWTDVMYWV-------------NDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSG 1107
+ E W ++M G ++ + YFV+ + L SF +LNL + V+
Sbjct: 1636 ATGEAWHEIMLSCLSNRPCDKLSGSGGKECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMD 1695
Query: 1108 EF 1113
F
Sbjct: 1696 NF 1697
Score = 85.9 bits (211), Expect = 1e-14
Identities = 71/263 (26%), Positives = 115/263 (42%), Gaps = 13/263 (4%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLFI S R + + F +L I+ + +LA E L A+ M L+
Sbjct: 66 SLFIFSEDCIIRKYAKKITEWPPFEYLILATIIANCIVLALEQHLPASDKTPMSERLDDT 125
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXX 2682
+ +F ++F E +K+I G FHKGS+ RN +N++D +VV LT + A
Sbjct: 126 EPYFIAIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVV---LTGMLATVGADFDLRT 182
Query: 2683 XXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTF- 2859
++ L+ V++ ++ A+ + I ++ F MFAIIG+ + G F
Sbjct: 183 LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGMLLFFAILMFAIIGLDFYMGKFH 242
Query: 2860 ---FLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRV----WSNNDF---NFDNVGDAM 3009
F + + E C E P + V W + NFDN+ A+
Sbjct: 243 RTCFRTDTGEQAAEFPCGLE-------APARTCENGTVCQEYWIGPTYGITNFDNILFAV 295
Query: 3010 ISLFVVSTFEGWPQLLYVAIDSN 3078
+S+F T EGW +LY A D++
Sbjct: 296 LSVFQCITMEGWVDILYNANDAS 318
Score = 80.1 bits (196), Expect = 6e-13
Identities = 72/291 (24%), Positives = 124/291 (41%), Gaps = 41/291 (14%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY+I I+ N + LA + H P+S + LD F +F FEA +KI+AL
Sbjct: 89 FEYLILATIIANCIVLALEQHLPASDKTPMSERLDDTEPYFIAIFCFEAGIKIIALGFAF 148
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WNV D +VV+ G L G + + R RV+R +KL+S
Sbjct: 149 HKGSYLRNGWNVMDFVVVL-------TGMLATVGAD-FDLRTLRAVRVLRPLKLVSGIPS 200
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-------------GKVALDDSTS 3834
++ +L + MK+ L + +L+ ++A+IG+ F+ G+ A +
Sbjct: 201 LQVVLKSIMKAMVPLLQIGMLLFFAILMFAIIGLDFYMGKFHRTCFRTDTGEQAAEFPCG 260
Query: 3835 I---------------------HRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDV 3951
+ + NF + A+L +F+ T E W DI+ + +D
Sbjct: 261 LEAPARTCENGTVCQEYWIGPTYGITNFDNILFAVLSVFQCITMEGWVDILYNANDAS-- 318
Query: 3952 RCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
GN + + YFI ++ SF ++NL + V+ F
Sbjct: 319 -------------------GNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 350
Score = 77.0 bits (188), Expect = 5e-12
Identities = 57/220 (25%), Positives = 93/220 (41%), Gaps = 9/220 (4%)
Frame = +1
Query: 1483 YGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVL 1662
+G E + N+ F LF++E +LK+ + G Y + +N FD V+ SI + ++
Sbjct: 1478 HGAPELYEAMLKHLNIVFTALFTLECILKIIAFGPLNYLKAAWNVFDFVTVLGSITDILV 1537
Query: 1663 VYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1842
K + +S LR R R+ K+ +
Sbjct: 1538 TEIKTDKLINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKGLPYVCLLIAMLFFIY 1597
Query: 1843 XXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIE------- 2001
GMQVFG P NF TF QAL+ +F+ TGE W+ +M +
Sbjct: 1598 AIIGMQVFGNIELNEETAINPHNNFRTFFQALMLLFRSATGEAWHEIMLSCLSNRPCDKL 1657
Query: 2002 SFGGVGTLGVIVCIYYIV--LFICGNYILLNVFLAIAVDN 2115
S G G +Y V +F+C ++++LN+F+A+ +DN
Sbjct: 1658 SGSGGKECGSDFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1696
Score = 46.6 bits (109), Expect = 0.007
Identities = 53/262 (20%), Positives = 103/262 (39%), Gaps = 3/262 (1%)
Frame = +1
Query: 2299 STVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANST 2478
++VK SS + R F +V F VL C++ + + A
Sbjct: 445 ASVKSSKLESSSYFRRKERRMRFFIRRMVKAQSFYWIVL-CLVGLNTLCVAIVHYDQPEW 503
Query: 2479 RNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFV--- 2649
L ++ F +F E++LK+ G ++ ++FN D V+ S+ V
Sbjct: 504 LTTGLYLAEFVFLGLFLSEMSLKMYGLGA----RNYFHSSFNCFDFSVIIGSILEVVWSM 559
Query: 2650 LRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAI 2829
++ A L+++V ++ ++K+I +++ + F+ +FA+
Sbjct: 560 IKPGASYGISVLRALRLLRLFKFTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFAL 619
Query: 2830 IGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAM 3009
+G+QLF G F ++E+ PT NFD A+
Sbjct: 620 LGMQLFGGQF-------------------NFEEETPTT-------------NFDTFPAAI 647
Query: 3010 ISLFVVSTFEGWPQLLYVAIDS 3075
+++F + T E W ++Y I+S
Sbjct: 648 LTVFQILTGEDWNAVMYHGIES 669
Score = 46.6 bits (109), Expect = 0.007
Identities = 48/227 (21%), Positives = 79/227 (34%), Gaps = 35/227 (15%)
Frame = +1
Query: 1534 FVILFSMEMLLKMYSLGFTTYTTSQF----NRFDCFVVISSILEFVLVYFDLMKPLGVSV 1701
F +F+ EM++KM LG + S F N D VV +++ F +
Sbjct: 1171 FTGVFTFEMVIKMIDLGLLLHPGSYFRDLWNILDFIVVSGALVAFACSGTKGKDINTIKS 1230
Query: 1702 LRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFN 1881
LR R+LR K K +Q+F GKF
Sbjct: 1231 LRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF 1290
Query: 1882 FNPQQPKP---------------------------RANFDTFVQALLTVFQILTGEDWNT 1980
+ + K ++D + A LT+F + TGE W
Sbjct: 1291 YCTDESKGLEKDCRGKFLDYDGDEVAAQDREWRKYEFHYDNVLWAFLTLFTVSTGEGWPM 1350
Query: 1981 VMYHGI----ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
V+ H + E G + I+Y+V F+ + +N+F+A+ +
Sbjct: 1351 VLKHSVDATYEDEGPSPGFRMETSIFYVVYFVVFPFFFVNIFVALII 1397
>gi|30794964|gb|AAP40629.1| voltage-gated calcium channel subunit
Cav2.2 variant I [Oncorhynchus mykiss]
Length = 2378
Score = 646 bits (1667), Expect = 0.0
Identities = 382/1001 (38%), Positives = 551/1001 (54%), Gaps = 42/1001 (4%)
Frame = +1
Query: 2308 KPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNM 2487
K I SS+F+ TN R C+ VVN YF +L I +SS LAAEDP+QAN+ RN
Sbjct: 1114 KHILPYSSMFVFGQTNPVRRLCHYVVNLRYFEMCILSVITMSSIALAAEDPVQANAPRNN 1173
Query: 2488 ILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL---RT 2658
+L Y DY FT VFT E+ +K+I GL+ H GS+ R+ +N+LD +VV+ +L +F +
Sbjct: 1174 VLKYLDYVFTGVFTFEMVIKMIDLGLLLHPGSYFRDLWNILDFIVVSGALVAFACSGTKG 1233
Query: 2659 DAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGV 2838
++ I R LK V CV+ ++K + NI++V + F+FA+I V
Sbjct: 1234 KDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAV 1293
Query: 2839 QLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISL 3018
QLFKG FF C D SK E +CRG+++ Y DGD ++ R W +F++DNV A ++L
Sbjct: 1294 QLFKGKFFYCTDESKGLEKDCRGKFLDY-DGDEV--AAQDREWRKYEFHYDNVLWAFLTL 1350
Query: 3019 FVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIVT 3198
F VST EGWP +L ++D+ ED+GP R ++ +I+T
Sbjct: 1351 FTVSTGEGWPMVLKHSVDATYEDEGPSPGFRMETSIFYVVYFVVFPFFFVNIFVALIIIT 1410
Query: 3199 FQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRAFEY--- 3363
FQ +G++ C L+KN+R CI+FA+ AKP RY+P ++ QY++W FV S FEY
Sbjct: 1411 FQEQGDKAMSECSLEKNERACIDFAINAKPLTRYMPADKQSFQYKMWQFVVSPPFEYSIM 1470
Query: 3364 -VIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDR 3540
+I +I +NTV L K + + +E L N++FT +F E +LKI+A P NY+
Sbjct: 1471 TMIMTMIALNTVVLMMKFHGAPELYEAMLKHLNIVFTALFTLECILKIIAFGPLNYLKAA 1530
Query: 3541 WNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFM 3720
WNVFD + V+GS DI ++ LI+++F RLFR RL+KLL +G IR LLWTF+
Sbjct: 1531 WNVFDFVTVLGSITDILVTEIKTD--KLINLSFLRLFRAARLIKLLRQGYTIRILLWTFV 1588
Query: 3721 KSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSAT 3900
+SF+ LPYV LLI +LFFIYA+IGMQ FG + L++ T+I+ +NNF +F A+++LFRSAT
Sbjct: 1589 QSFKGLPYVCLLIAMLFFIYAIIGMQVFGNIELNEETAINPHNNFRTFFQALMLLFRSAT 1648
Query: 3901 GEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLF 4080
GEAW +IMLSC CD +S G CG++FAY YF+SF LCSFL++NLF
Sbjct: 1649 GEAWHEIMLSCLSNRP--CDKLS------GSGGKECGSDFAYFYFVSFIFLCSFLMLNLF 1700
Query: 4081 VAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFG 4260
VAVIMDNF+YLTRD SILGPHHL+EF+R+W+EYDP A GR+ +LD+ +LR +SPPLG G
Sbjct: 1701 VAVIMDNFEYLTRDASILGPHHLDEFIRVWAEYDPAACGRMTYLDMYEMLRHMSPPLGLG 1760
Query: 4261 KLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNI---DEANEQLRSA 4431
K CP R+A KRLV MNMP+ D TV F +TL AL+RT L+I + + LR
Sbjct: 1761 KKCPPRIAYKRLVKMNMPIADDNTVHFTSTLMALIRTALEIKLASGVLAQRLCDADLRKE 1820
Query: 4432 IKRIWKRTHKDLLDEVVPPAGKED-------------DVTVGKFYATFLIQDYFRRFKKR 4572
I R+W + +D +V P ++ ++TVGK YA +I DY+++ + +
Sbjct: 1821 ISRVWPNLPQKTIDLLVTPYKNDEFNELLCPFAVVNRELTVGKVYAALMIFDYYKQNRAK 1880
Query: 4573 KEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDEPEPQHR-RPHS 4749
+ + G+ T + A R + + + + +PEP+ + P
Sbjct: 1881 RLEQQLGLDFTGTIKNKKGPAFFRPMMPMTHMQEEGTTVAGANPLPSSQPEPESQPEPTP 1940
Query: 4750 LFNNLVHRLSGAGSKSPTEHERIEKGSTLLPFQPRSFSPTHSLAGAEGSPVP-------- 4905
+L + + ++SP + E G L RS S L + VP
Sbjct: 1941 STTSLTNGEAVPSTRSPIK----ESGEQLSQEGQRSSSRKRILQRGQSEDVPYSNKPQES 1996
Query: 4906 ---SQMHRGAPINQSINLPPVNGSARRLPALPPYANHIHDETDDGPRYRDTGDRAGYDQS 5076
Q+ GA I L +G A +P L N H G D + +S
Sbjct: 1997 VEMRQVENGADIGGYSGLDG-HGRAASMPRLDSQYNRTHPRHRPGSYLAPIADISPIRRS 2055
Query: 5077 SRMVVA--NRNLPV---DPDEEEQWMRSGGPSNRSDRRNPH 5184
+ + + +R + + + Q S P DR + H
Sbjct: 2056 ASTLASQCHREMSLRVYTLERPSQAQASSAPGQAQDRPHHH 2096
Score = 337 bits (863), Expect = 3e-90
Identities = 170/345 (49%), Positives = 230/345 (66%)
Frame = +1
Query: 229 IRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTI 408
IRK I EW PFE+LIL I ANCI LA+ Q PA D + L+ E FI +F
Sbjct: 76 IRKYAKKITEWPPFEYLILATIIANCIVLALEQHLPASDKTPMSERLDDTEPYFIAIFCF 135
Query: 409 ECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLR 588
E +KI+A+GF FH +YLRN WN++DF++V+ G+++T+ + FD++ LRA RVLR
Sbjct: 136 EAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGMLATVGAD-----FDLRTLRAVRVLR 190
Query: 589 PLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPAT 768
PL+LVSG+PSLQVVL +I++AM+PLL I +L+ F IL++AIIGL+ + GK H TC T
Sbjct: 191 PLKLVSGIPSLQVVLKSIMKAMVPLLQIGMLLFFAILMFAIIGLDFYMGKFHRTCFRTDT 250
Query: 769 GQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAM 948
G+ A + PCG + P+ + N V E W GP GITNFDN A+
Sbjct: 251 GEQAAE--FPCGLEA--------PARTCENGTVCQEY-----WIGPTYGITNFDNILFAV 295
Query: 949 LTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKERE 1128
L+VFQC+++EGW D++Y NDA G W W+YF+ L+I+GSFF+LNLVLGVLSGEF+KERE
Sbjct: 296 LSVFQCITMEGWVDILYNANDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERE 355
Query: 1129 KARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDE 1263
+ R F K R +QQ+E +L GYL+WI +AE++ EDE +E
Sbjct: 356 RVEKRQDFLKLRRQQQIERELTGYLEWICKAEEVLLEEEDENAEE 400
Score = 204 bits (518), Expect = 3e-50
Identities = 119/248 (47%), Positives = 141/248 (55%), Gaps = 3/248 (1%)
Frame = +1
Query: 1405 LVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLG 1584
+VK+Q+FYW HY Q EWL +A F+ LF EM LKMY LG
Sbjct: 483 MVKAQSFYWIVLCLVGLNTLCVAIVHYDQPEWLTTGLYLAEFVFLGLFLSEMSLKMYGLG 542
Query: 1585 FTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKP---LGVSVLRSARLLRIFKVTKYWTX 1755
Y S FN FD V+I SILE V + ++KP G+SVLR+ RLLR+FK TKYW
Sbjct: 543 ARNYFHSSFNCFDFSVIIGSILEVV---WSMIKPGASYGISVLRALRLLRLFKFTKYWNS 599
Query: 1756 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQA 1935
GMQ+FGG+FNF ++ P NFDTF A
Sbjct: 600 LRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF--EEETPTTNFDTFPAA 657
Query: 1936 LLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDN 2115
+LTVFQILTGEDWN VMYHGIES GGV G+ +Y+IVL + GNY LLNVFLAIAVDN
Sbjct: 658 ILTVFQILTGEDWNAVMYHGIESQGGV-RRGMFSSVYFIVLTLFGNYTLLNVFLAIAVDN 716
Query: 2116 LADADSLT 2139
LA+A LT
Sbjct: 717 LANAQELT 724
Score = 138 bits (348), Expect = 1e-30
Identities = 98/324 (30%), Positives = 163/324 (50%), Gaps = 12/324 (3%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+R+LC +V + FE IL +I + IALA P A +N +L+ ++YVF VF
Sbjct: 1129 NPVRRLCHYVVNLRYFEMCILSVITMSSIALAAEDPVQANAP--RNNVLKYLDYVFTGVF 1186
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD---VKALRA 573
T E V+K++ +G + HP +Y R+ WNILDFI+V LV+ S +G D +K+LR
Sbjct: 1187 TFEMVIKMIDLGLLLHPGSYFRDLWNILDFIVVSGALVAFACS--GTKGKDINTIKSLRV 1244
Query: 574 FRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTC 753
RVLRPL+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF GK C
Sbjct: 1245 LRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF-YC 1303
Query: 754 IDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDN 933
D + G +KD D +G Q + W ++DN
Sbjct: 1304 TDESKG--LEKDCRGKFLDYDGDEVAAQDRE--------WRKYE-----------FHYDN 1342
Query: 934 FGLAMLTVFQCVSLEGWTDVMYWVNDAV---------GREWPWIYFVTLVILGSFFVLNL 1086
A LT+F + EGW V+ DA R I++V ++ FF +N+
Sbjct: 1343 VLWAFLTLFTVSTGEGWPMVLKHSVDATYEDEGPSPGFRMETSIFYVVYFVVFPFFFVNI 1402
Query: 1087 VLGVLSGEFSKEREKARARGLFQK 1158
+ ++ F ++ +KA + +K
Sbjct: 1403 FVALIIITFQEQGDKAMSECSLEK 1426
Score = 123 bits (308), Expect = 6e-26
Identities = 75/278 (26%), Positives = 140/278 (49%), Gaps = 8/278 (2%)
Frame = +1
Query: 3313 RLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEA 3492
R+++ + V +++F +++ ++ +NT+ +A HY L + +F G+F E
Sbjct: 475 RMRFFIRRMVKAQSFYWIVLCLVGLNTLCVAIVHYDQPEWLTTGLYLAEFVFLGLFLSEM 534
Query: 3493 VLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVK 3672
LK+ L +NY +N FD V++GS +++ + + PG + IS+ R R++RL K
Sbjct: 535 SLKMYGLGARNYFHSSFNCFDFSVIIGSILEVVWSMIKPGASYGISV--LRALRLLRLFK 592
Query: 3673 LLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNN 3849
+R L+ + + S +++ + L+ L ++A++GMQ F G+ ++ T
Sbjct: 593 FTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFEEETP---TT 649
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYH----KGGLNESRCGNN 4017
NF +FPAAIL +F+ TGE W +M YH +GG+
Sbjct: 650 NFDTFPAAILTVFQILTGEDWNAVM-----------------YHGIESQGGVRRGM---- 688
Query: 4018 FAYPYFISFFMLCSFLVINLFVAVIMDNF---DYLTRD 4122
F+ YFI + ++ ++N+F+A+ +DN LT+D
Sbjct: 689 FSSVYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 726
Score = 88.2 bits (217), Expect = 2e-15
Identities = 72/302 (23%), Positives = 135/302 (43%), Gaps = 19/302 (6%)
Frame = +1
Query: 265 PFEF----LILFMICANCIALAI-YQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIV 429
PFE+ +I+ MI N + L + + P + +L+ + VF +FT+EC+LKI+
Sbjct: 1464 PFEYSIMTMIMTMIALNTVVLMMKFHGAP----ELYEAMLKHLNIVFTALFTLECILKII 1519
Query: 430 AMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGF-DVKALRAFRVLRPLRLVS 606
A G P YL+ AWN+ DF+ V+ + +++++ ++ LR FR R ++L+
Sbjct: 1520 AFG----PLNYLKAAWNVFDFVTVLGSITDILVTEIKTDKLINLSFLRLFRAARLIKLLR 1575
Query: 607 GVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQK 786
+++++L +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1576 QGYTIRILLWTFVQSFKGLPYVCLLIAMLFFIYAIIGMQVF------------------- 1616
Query: 787 DPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQC 966
N+ + E + N P+N NF F A++ +F+
Sbjct: 1617 ----------------------GNIELNEETAIN-----PHN---NFRTFFQALMLLFRS 1646
Query: 967 VSLEGWTDVMYWV-------------NDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSG 1107
+ E W ++M G ++ + YFV+ + L SF +LNL + V+
Sbjct: 1647 ATGEAWHEIMLSCLSNRPCDKLSGSGGKECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMD 1706
Query: 1108 EF 1113
F
Sbjct: 1707 NF 1708
Score = 87.8 bits (216), Expect = 3e-15
Identities = 73/336 (21%), Positives = 149/336 (43%), Gaps = 5/336 (1%)
Frame = +1
Query: 250 IVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIV 429
+V+ + F +++L ++ N + +AI ++ T L E+VF+ +F E LK+
Sbjct: 483 MVKAQSFYWIVLCLVGLNTLCVAIVH---YDQPEWLTTGLYLAEFVFLGLFLSEMSLKMY 539
Query: 430 AMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSI-QGFDVKALRAFRVLRPLRLVS 606
+G Y +++N DF +++ ++ + S + + + LRA R+LR +
Sbjct: 540 GLG----ARNYFHSSFNCFDFSVIIGSILEVVWSMIKPGASYGISVLRALRLLRLFKFTK 595
Query: 607 GVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQK 786
SL+ ++ ++L +M ++ + L+ I+++A++G++LF G+ + ++
Sbjct: 596 YWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFN----------FEEE 645
Query: 787 DPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQC 966
PT TNFD F A+LTVFQ
Sbjct: 646 TPT-----------------------------------------TNFDTFPAAILTVFQI 664
Query: 967 VSLEGWTDVMYWVNDAVG----REWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKA 1134
++ E W VMY ++ G + +YF+ L + G++ +LN+ L + + +E
Sbjct: 665 LTGEDWNAVMYHGIESQGGVRRGMFSSVYFIVLTLFGNYTLLNVFLAIAVDNLANAQE-- 722
Query: 1135 RARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVN 1242
K EKQ+ E + K L + +++ P++
Sbjct: 723 -----LTKDEEKQEEEANKKLALQKAMEVKEVSPMS 753
Score = 85.9 bits (211), Expect = 1e-14
Identities = 71/263 (26%), Positives = 115/263 (42%), Gaps = 13/263 (4%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLFI S R + + F +L I+ + +LA E L A+ M L+
Sbjct: 66 SLFIFSEDCIIRKYAKKITEWPPFEYLILATIIANCIVLALEQHLPASDKTPMSERLDDT 125
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXX 2682
+ +F ++F E +K+I G FHKGS+ RN +N++D +VV LT + A
Sbjct: 126 EPYFIAIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVV---LTGMLATVGADFDLRT 182
Query: 2683 XXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTF- 2859
++ L+ V++ ++ A+ + I ++ F MFAIIG+ + G F
Sbjct: 183 LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGMLLFFAILMFAIIGLDFYMGKFH 242
Query: 2860 ---FLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRV----WSNNDF---NFDNVGDAM 3009
F + + E C E P + V W + NFDN+ A+
Sbjct: 243 RTCFRTDTGEQAAEFPCGLE-------APARTCENGTVCQEYWIGPTYGITNFDNILFAV 295
Query: 3010 ISLFVVSTFEGWPQLLYVAIDSN 3078
+S+F T EGW +LY A D++
Sbjct: 296 LSVFQCITMEGWVDILYNANDAS 318
Score = 80.1 bits (196), Expect = 6e-13
Identities = 72/291 (24%), Positives = 124/291 (41%), Gaps = 41/291 (14%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY+I I+ N + LA + H P+S + LD F +F FEA +KI+AL
Sbjct: 89 FEYLILATIIANCIVLALEQHLPASDKTPMSERLDDTEPYFIAIFCFEAGIKIIALGFAF 148
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WNV D +VV+ G L G + + R RV+R +KL+S
Sbjct: 149 HKGSYLRNGWNVMDFVVVL-------TGMLATVGAD-FDLRTLRAVRVLRPLKLVSGIPS 200
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-------------GKVALDDSTS 3834
++ +L + MK+ L + +L+ ++A+IG+ F+ G+ A +
Sbjct: 201 LQVVLKSIMKAMVPLLQIGMLLFFAILMFAIIGLDFYMGKFHRTCFRTDTGEQAAEFPCG 260
Query: 3835 I---------------------HRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDV 3951
+ + NF + A+L +F+ T E W DI+ + +D
Sbjct: 261 LEAPARTCENGTVCQEYWIGPTYGITNFDNILFAVLSVFQCITMEGWVDILYNANDAS-- 318
Query: 3952 RCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
GN + + YFI ++ SF ++NL + V+ F
Sbjct: 319 -------------------GNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 350
Score = 77.0 bits (188), Expect = 5e-12
Identities = 57/220 (25%), Positives = 93/220 (41%), Gaps = 9/220 (4%)
Frame = +1
Query: 1483 YGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVL 1662
+G E + N+ F LF++E +LK+ + G Y + +N FD V+ SI + ++
Sbjct: 1489 HGAPELYEAMLKHLNIVFTALFTLECILKIIAFGPLNYLKAAWNVFDFVTVLGSITDILV 1548
Query: 1663 VYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1842
K + +S LR R R+ K+ +
Sbjct: 1549 TEIKTDKLINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKGLPYVCLLIAMLFFIY 1608
Query: 1843 XXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIE------- 2001
GMQVFG P NF TF QAL+ +F+ TGE W+ +M +
Sbjct: 1609 AIIGMQVFGNIELNEETAINPHNNFRTFFQALMLLFRSATGEAWHEIMLSCLSNRPCDKL 1668
Query: 2002 SFGGVGTLGVIVCIYYIV--LFICGNYILLNVFLAIAVDN 2115
S G G +Y V +F+C ++++LN+F+A+ +DN
Sbjct: 1669 SGSGGKECGSDFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1707
Score = 48.9 bits (115), Expect = 0.001
Identities = 50/229 (21%), Positives = 85/229 (36%), Gaps = 38/229 (16%)
Frame = +1
Query: 1531 FFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVS 1698
+F+ +F E +K+ +LGF +Y + +N D VV++ +L V FDL
Sbjct: 128 YFIAIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGMLATVGADFDLR------ 181
Query: 1699 VLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKF 1878
LR+ R+LR K+ G+ + GKF
Sbjct: 182 TLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGMLLFFAILMFAIIGLDFYMGKF 241
Query: 1879 N---FNPQQPKPRA-------------------------------NFDTFVQALLTVFQI 1956
+ F + A NFD + A+L+VFQ
Sbjct: 242 HRTCFRTDTGEQAAEFPCGLEAPARTCENGTVCQEYWIGPTYGITNFDNILFAVLSVFQC 301
Query: 1957 LTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAI 2103
+T E W ++Y+ ++ G +Y+I L I G++ +LN+ L +
Sbjct: 302 ITMEGWVDILYNANDASGNTWN-----WLYFIPLIIIGSFFMLNLVLGV 345
Score = 46.6 bits (109), Expect = 0.007
Identities = 53/262 (20%), Positives = 103/262 (39%), Gaps = 3/262 (1%)
Frame = +1
Query: 2299 STVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANST 2478
++VK SS + R F +V F VL C++ + + A
Sbjct: 456 ASVKSSKLESSSYFRRKERRMRFFIRRMVKAQSFYWIVL-CLVGLNTLCVAIVHYDQPEW 514
Query: 2479 RNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFV--- 2649
L ++ F +F E++LK+ G ++ ++FN D V+ S+ V
Sbjct: 515 LTTGLYLAEFVFLGLFLSEMSLKMYGLGA----RNYFHSSFNCFDFSVIIGSILEVVWSM 570
Query: 2650 LRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAI 2829
++ A L+++V ++ ++K+I +++ + F+ +FA+
Sbjct: 571 IKPGASYGISVLRALRLLRLFKFTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFAL 630
Query: 2830 IGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAM 3009
+G+QLF G F ++E+ PT NFD A+
Sbjct: 631 LGMQLFGGQF-------------------NFEEETPTT-------------NFDTFPAAI 658
Query: 3010 ISLFVVSTFEGWPQLLYVAIDS 3075
+++F + T E W ++Y I+S
Sbjct: 659 LTVFQILTGEDWNAVMYHGIES 680
Score = 46.6 bits (109), Expect = 0.007
Identities = 48/227 (21%), Positives = 79/227 (34%), Gaps = 35/227 (15%)
Frame = +1
Query: 1534 FVILFSMEMLLKMYSLGFTTYTTSQF----NRFDCFVVISSILEFVLVYFDLMKPLGVSV 1701
F +F+ EM++KM LG + S F N D VV +++ F +
Sbjct: 1182 FTGVFTFEMVIKMIDLGLLLHPGSYFRDLWNILDFIVVSGALVAFACSGTKGKDINTIKS 1241
Query: 1702 LRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFN 1881
LR R+LR K K +Q+F GKF
Sbjct: 1242 LRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF 1301
Query: 1882 FNPQQPKP---------------------------RANFDTFVQALLTVFQILTGEDWNT 1980
+ + K ++D + A LT+F + TGE W
Sbjct: 1302 YCTDESKGLEKDCRGKFLDYDGDEVAAQDREWRKYEFHYDNVLWAFLTLFTVSTGEGWPM 1361
Query: 1981 VMYHGI----ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
V+ H + E G + I+Y+V F+ + +N+F+A+ +
Sbjct: 1362 VLKHSVDATYEDEGPSPGFRMETSIFYVVYFVVFPFFFVNIFVALII 1408
>gi|30794966|gb|AAP40630.1| voltage-gated calcium channel subunit
Cav2.2 variant II [Oncorhynchus mykiss]
Length = 2367
Score = 646 bits (1667), Expect = 0.0
Identities = 382/1001 (38%), Positives = 551/1001 (54%), Gaps = 42/1001 (4%)
Frame = +1
Query: 2308 KPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNM 2487
K I SS+F+ TN R C+ VVN YF +L I +SS LAAEDP+QAN+ RN
Sbjct: 1103 KHILPYSSMFVFGQTNPVRRLCHYVVNLRYFEMCILSVITMSSIALAAEDPVQANAPRNN 1162
Query: 2488 ILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL---RT 2658
+L Y DY FT VFT E+ +K+I GL+ H GS+ R+ +N+LD +VV+ +L +F +
Sbjct: 1163 VLKYLDYVFTGVFTFEMVIKMIDLGLLLHPGSYFRDLWNILDFIVVSGALVAFACSGTKG 1222
Query: 2659 DAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGV 2838
++ I R LK V CV+ ++K + NI++V + F+FA+I V
Sbjct: 1223 KDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAV 1282
Query: 2839 QLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISL 3018
QLFKG FF C D SK E +CRG+++ Y DGD ++ R W +F++DNV A ++L
Sbjct: 1283 QLFKGKFFYCTDESKGLEKDCRGKFLDY-DGDEV--AAQDREWRKYEFHYDNVLWAFLTL 1339
Query: 3019 FVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIVT 3198
F VST EGWP +L ++D+ ED+GP R ++ +I+T
Sbjct: 1340 FTVSTGEGWPMVLKHSVDATYEDEGPSPGFRMETSIFYVVYFVVFPFFFVNIFVALIIIT 1399
Query: 3199 FQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRAFEY--- 3363
FQ +G++ C L+KN+R CI+FA+ AKP RY+P ++ QY++W FV S FEY
Sbjct: 1400 FQEQGDKAMSECSLEKNERACIDFAINAKPLTRYMPADKQSFQYKMWQFVVSPPFEYSIM 1459
Query: 3364 -VIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDR 3540
+I +I +NTV L K + + +E L N++FT +F E +LKI+A P NY+
Sbjct: 1460 TMIMTMIALNTVVLMMKFHGAPELYEAMLKHLNIVFTALFTLECILKIIAFGPLNYLKAA 1519
Query: 3541 WNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFM 3720
WNVFD + V+GS DI ++ LI+++F RLFR RL+KLL +G IR LLWTF+
Sbjct: 1520 WNVFDFVTVLGSITDILVTEIKTD--KLINLSFLRLFRAARLIKLLRQGYTIRILLWTFV 1577
Query: 3721 KSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSAT 3900
+SF+ LPYV LLI +LFFIYA+IGMQ FG + L++ T+I+ +NNF +F A+++LFRSAT
Sbjct: 1578 QSFKGLPYVCLLIAMLFFIYAIIGMQVFGNIELNEETAINPHNNFRTFFQALMLLFRSAT 1637
Query: 3901 GEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLF 4080
GEAW +IMLSC CD +S G CG++FAY YF+SF LCSFL++NLF
Sbjct: 1638 GEAWHEIMLSCLSNRP--CDKLS------GSGGKECGSDFAYFYFVSFIFLCSFLMLNLF 1689
Query: 4081 VAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFG 4260
VAVIMDNF+YLTRD SILGPHHL+EF+R+W+EYDP A GR+ +LD+ +LR +SPPLG G
Sbjct: 1690 VAVIMDNFEYLTRDASILGPHHLDEFIRVWAEYDPAACGRMTYLDMYEMLRHMSPPLGLG 1749
Query: 4261 KLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNI---DEANEQLRSA 4431
K CP R+A KRLV MNMP+ D TV F +TL AL+RT L+I + + LR
Sbjct: 1750 KKCPPRIAYKRLVKMNMPIADDNTVHFTSTLMALIRTALEIKLASGVLAQRLCDADLRKE 1809
Query: 4432 IKRIWKRTHKDLLDEVVPPAGKED-------------DVTVGKFYATFLIQDYFRRFKKR 4572
I R+W + +D +V P ++ ++TVGK YA +I DY+++ + +
Sbjct: 1810 ISRVWPNLPQKTIDLLVTPYKNDEFNELLCPFAVVNRELTVGKVYAALMIFDYYKQNRAK 1869
Query: 4573 KEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKRAISGNLETDFNFDEPEPQHR-RPHS 4749
+ + G+ T + A R + + + + +PEP+ + P
Sbjct: 1870 RLEQQLGLDFTGTIKNKKGPAFFRPMMPMTHMQEEGTTVAGANPLPSSQPEPESQPEPTP 1929
Query: 4750 LFNNLVHRLSGAGSKSPTEHERIEKGSTLLPFQPRSFSPTHSLAGAEGSPVP-------- 4905
+L + + ++SP + E G L RS S L + VP
Sbjct: 1930 STTSLTNGEAVPSTRSPIK----ESGEQLSQEGQRSSSRKRILQRGQSEDVPYSNKPQES 1985
Query: 4906 ---SQMHRGAPINQSINLPPVNGSARRLPALPPYANHIHDETDDGPRYRDTGDRAGYDQS 5076
Q+ GA I L +G A +P L N H G D + +S
Sbjct: 1986 VEMRQVENGADIGGYSGLDG-HGRAASMPRLDSQYNRTHPRHRPGSYLAPIADISPIRRS 2044
Query: 5077 SRMVVA--NRNLPV---DPDEEEQWMRSGGPSNRSDRRNPH 5184
+ + + +R + + + Q S P DR + H
Sbjct: 2045 ASTLASQCHREMSLRVYTLERPSQAQASSAPGQAQDRPHHH 2085
Score = 512 bits (1318), Expect = e-143
Identities = 291/664 (43%), Positives = 379/664 (56%), Gaps = 27/664 (4%)
Frame = +1
Query: 229 IRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTI 408
IRK I EW PFE+LIL I ANCI LA+ Q PA D + L+ E FI +F
Sbjct: 76 IRKYAKKITEWPPFEYLILATIIANCIVLALEQHLPASDKTPMSERLDDTEPYFIAIFCF 135
Query: 409 ECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLR 588
E +KI+A+GF FH +YLRN WN++DF++V+ G+++T+ + FD++ LRA RVLR
Sbjct: 136 EAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGMLATVGAD-----FDLRTLRAVRVLR 190
Query: 589 PLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPAT 768
PL+LVSG+PSLQVVL +I++AM+PLL I +L+ F IL++AIIGL+ + GK H TC T
Sbjct: 191 PLKLVSGIPSLQVVLKSIMKAMVPLLQIGMLLFFAILMFAIIGLDFYMGKFHRTCFRTDT 250
Query: 769 GQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAM 948
G+ A + PCG + P+ + N V E W GP GITNFDN A+
Sbjct: 251 GEQAAE--FPCGLEA--------PARTCENGTVCQEY-----WIGPTYGITNFDNILFAV 295
Query: 949 LTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKERE 1128
L+VFQC+++EGW D++Y NDA G W W+YF+ L+I+GSFF+LNLVLGVLSGEF+KERE
Sbjct: 296 LSVFQCITMEGWVDILYNANDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERE 355
Query: 1129 KARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEP-------------- 1266
+ R F K R +QQ+E +L GYL+WI +AE++ EDE +E
Sbjct: 356 RVEKRQDFLKLRRQQQIERELTGYLEWICKAEEVLLEEEDENAEEKSPLDVLKRGKVKKS 415
Query: 1267 ----VAQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLE------KLNXXXXXXXXXLVKS 1416
+ + + + +LE + +VK+
Sbjct: 416 KNDLIGAEEGEDHFTDMSSVAPPGSPFGRASVKSSKLESSSYFRRKERRMRFFIRRMVKA 475
Query: 1417 QTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTY 1596
Q+FYW HY Q EWL +A F+ LF EM LKMY LG Y
Sbjct: 476 QSFYWIVLCLVGLNTLCVAIVHYDQPEWLTTGLYLAEFVFLGLFLSEMSLKMYGLGARNY 535
Query: 1597 TTSQFNRFDCFVVISSILEFVLVYFDLMKP---LGVSVLRSARLLRIFKVTKYWTXXXXX 1767
S FN FD V+I SILE V + ++KP G+SVLR+ RLLR+FK TKYW
Sbjct: 536 FHSSFNCFDFSVIIGSILE---VVWSMIKPGASYGISVLRALRLLRLFKFTKYWNSLRNL 592
Query: 1768 XXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTV 1947
GMQ+FGG+FNF ++ P NFDTF A+LTV
Sbjct: 593 VVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF--EEETPTTNFDTFPAAILTV 650
Query: 1948 FQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADA 2127
FQILTGEDWN VMYHGIES GGV G+ +Y+IVL + GNY LLNVFLAIAVDNLA+A
Sbjct: 651 FQILTGEDWNAVMYHGIESQGGV-RRGMFSSVYFIVLTLFGNYTLLNVFLAIAVDNLANA 709
Query: 2128 DSLT 2139
LT
Sbjct: 710 QELT 713
Score = 138 bits (348), Expect = 1e-30
Identities = 98/324 (30%), Positives = 163/324 (50%), Gaps = 12/324 (3%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+R+LC +V + FE IL +I + IALA P A +N +L+ ++YVF VF
Sbjct: 1118 NPVRRLCHYVVNLRYFEMCILSVITMSSIALAAEDPVQANAP--RNNVLKYLDYVFTGVF 1175
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD---VKALRA 573
T E V+K++ +G + HP +Y R+ WNILDFI+V LV+ S +G D +K+LR
Sbjct: 1176 TFEMVIKMIDLGLLLHPGSYFRDLWNILDFIVVSGALVAFACS--GTKGKDINTIKSLRV 1233
Query: 574 FRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTC 753
RVLRPL+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF GK C
Sbjct: 1234 LRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF-YC 1292
Query: 754 IDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDN 933
D + G +KD D +G Q + W ++DN
Sbjct: 1293 TDESKG--LEKDCRGKFLDYDGDEVAAQDRE--------WRKYE-----------FHYDN 1331
Query: 934 FGLAMLTVFQCVSLEGWTDVMYWVNDAV---------GREWPWIYFVTLVILGSFFVLNL 1086
A LT+F + EGW V+ DA R I++V ++ FF +N+
Sbjct: 1332 VLWAFLTLFTVSTGEGWPMVLKHSVDATYEDEGPSPGFRMETSIFYVVYFVVFPFFFVNI 1391
Query: 1087 VLGVLSGEFSKEREKARARGLFQK 1158
+ ++ F ++ +KA + +K
Sbjct: 1392 FVALIIITFQEQGDKAMSECSLEK 1415
Score = 123 bits (308), Expect = 6e-26
Identities = 75/278 (26%), Positives = 140/278 (49%), Gaps = 8/278 (2%)
Frame = +1
Query: 3313 RLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEA 3492
R+++ + V +++F +++ ++ +NT+ +A HY L + +F G+F E
Sbjct: 464 RMRFFIRRMVKAQSFYWIVLCLVGLNTLCVAIVHYDQPEWLTTGLYLAEFVFLGLFLSEM 523
Query: 3493 VLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVK 3672
LK+ L +NY +N FD V++GS +++ + + PG + IS+ R R++RL K
Sbjct: 524 SLKMYGLGARNYFHSSFNCFDFSVIIGSILEVVWSMIKPGASYGISV--LRALRLLRLFK 581
Query: 3673 LLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNN 3849
+R L+ + + S +++ + L+ L ++A++GMQ F G+ ++ T
Sbjct: 582 FTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFEEETP---TT 638
Query: 3850 NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYH----KGGLNESRCGNN 4017
NF +FPAAIL +F+ TGE W +M YH +GG+
Sbjct: 639 NFDTFPAAILTVFQILTGEDWNAVM-----------------YHGIESQGGVRRGM---- 677
Query: 4018 FAYPYFISFFMLCSFLVINLFVAVIMDNF---DYLTRD 4122
F+ YFI + ++ ++N+F+A+ +DN LT+D
Sbjct: 678 FSSVYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 715
Score = 88.2 bits (217), Expect = 2e-15
Identities = 72/302 (23%), Positives = 135/302 (43%), Gaps = 19/302 (6%)
Frame = +1
Query: 265 PFEF----LILFMICANCIALAI-YQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIV 429
PFE+ +I+ MI N + L + + P + +L+ + VF +FT+EC+LKI+
Sbjct: 1453 PFEYSIMTMIMTMIALNTVVLMMKFHGAP----ELYEAMLKHLNIVFTALFTLECILKII 1508
Query: 430 AMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGF-DVKALRAFRVLRPLRLVS 606
A G P YL+ AWN+ DF+ V+ + +++++ ++ LR FR R ++L+
Sbjct: 1509 AFG----PLNYLKAAWNVFDFVTVLGSITDILVTEIKTDKLINLSFLRLFRAARLIKLLR 1564
Query: 607 GVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQK 786
+++++L +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1565 QGYTIRILLWTFVQSFKGLPYVCLLIAMLFFIYAIIGMQVF------------------- 1605
Query: 787 DPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQC 966
N+ + E + N P+N NF F A++ +F+
Sbjct: 1606 ----------------------GNIELNEETAIN-----PHN---NFRTFFQALMLLFRS 1635
Query: 967 VSLEGWTDVMYWV-------------NDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSG 1107
+ E W ++M G ++ + YFV+ + L SF +LNL + V+
Sbjct: 1636 ATGEAWHEIMLSCLSNRPCDKLSGSGGKECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMD 1695
Query: 1108 EF 1113
F
Sbjct: 1696 NF 1697
Score = 87.8 bits (216), Expect = 3e-15
Identities = 73/336 (21%), Positives = 149/336 (43%), Gaps = 5/336 (1%)
Frame = +1
Query: 250 IVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIV 429
+V+ + F +++L ++ N + +AI ++ T L E+VF+ +F E LK+
Sbjct: 472 MVKAQSFYWIVLCLVGLNTLCVAIVH---YDQPEWLTTGLYLAEFVFLGLFLSEMSLKMY 528
Query: 430 AMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSI-QGFDVKALRAFRVLRPLRLVS 606
+G Y +++N DF +++ ++ + S + + + LRA R+LR +
Sbjct: 529 GLG----ARNYFHSSFNCFDFSVIIGSILEVVWSMIKPGASYGISVLRALRLLRLFKFTK 584
Query: 607 GVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQK 786
SL+ ++ ++L +M ++ + L+ I+++A++G++LF G+ + ++
Sbjct: 585 YWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFN----------FEEE 634
Query: 787 DPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQC 966
PT TNFD F A+LTVFQ
Sbjct: 635 TPT-----------------------------------------TNFDTFPAAILTVFQI 653
Query: 967 VSLEGWTDVMYWVNDAVG----REWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKA 1134
++ E W VMY ++ G + +YF+ L + G++ +LN+ L + + +E
Sbjct: 654 LTGEDWNAVMYHGIESQGGVRRGMFSSVYFIVLTLFGNYTLLNVFLAIAVDNLANAQE-- 711
Query: 1135 RARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVN 1242
K EKQ+ E + K L + +++ P++
Sbjct: 712 -----LTKDEEKQEEEANKKLALQKAMEVKEVSPMS 742
Score = 85.9 bits (211), Expect = 1e-14
Identities = 71/263 (26%), Positives = 115/263 (42%), Gaps = 13/263 (4%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLFI S R + + F +L I+ + +LA E L A+ M L+
Sbjct: 66 SLFIFSEDCIIRKYAKKITEWPPFEYLILATIIANCIVLALEQHLPASDKTPMSERLDDT 125
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXX 2682
+ +F ++F E +K+I G FHKGS+ RN +N++D +VV LT + A
Sbjct: 126 EPYFIAIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVV---LTGMLATVGADFDLRT 182
Query: 2683 XXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTF- 2859
++ L+ V++ ++ A+ + I ++ F MFAIIG+ + G F
Sbjct: 183 LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGMLLFFAILMFAIIGLDFYMGKFH 242
Query: 2860 ---FLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRV----WSNNDF---NFDNVGDAM 3009
F + + E C E P + V W + NFDN+ A+
Sbjct: 243 RTCFRTDTGEQAAEFPCGLE-------APARTCENGTVCQEYWIGPTYGITNFDNILFAV 295
Query: 3010 ISLFVVSTFEGWPQLLYVAIDSN 3078
+S+F T EGW +LY A D++
Sbjct: 296 LSVFQCITMEGWVDILYNANDAS 318
Score = 80.1 bits (196), Expect = 6e-13
Identities = 72/291 (24%), Positives = 124/291 (41%), Gaps = 41/291 (14%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY+I I+ N + LA + H P+S + LD F +F FEA +KI+AL
Sbjct: 89 FEYLILATIIANCIVLALEQHLPASDKTPMSERLDDTEPYFIAIFCFEAGIKIIALGFAF 148
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WNV D +VV+ G L G + + R RV+R +KL+S
Sbjct: 149 HKGSYLRNGWNVMDFVVVL-------TGMLATVGAD-FDLRTLRAVRVLRPLKLVSGIPS 200
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-------------GKVALDDSTS 3834
++ +L + MK+ L + +L+ ++A+IG+ F+ G+ A +
Sbjct: 201 LQVVLKSIMKAMVPLLQIGMLLFFAILMFAIIGLDFYMGKFHRTCFRTDTGEQAAEFPCG 260
Query: 3835 I---------------------HRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDV 3951
+ + NF + A+L +F+ T E W DI+ + +D
Sbjct: 261 LEAPARTCENGTVCQEYWIGPTYGITNFDNILFAVLSVFQCITMEGWVDILYNANDAS-- 318
Query: 3952 RCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
GN + + YFI ++ SF ++NL + V+ F
Sbjct: 319 -------------------GNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 350
Score = 77.0 bits (188), Expect = 5e-12
Identities = 57/220 (25%), Positives = 93/220 (41%), Gaps = 9/220 (4%)
Frame = +1
Query: 1483 YGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVL 1662
+G E + N+ F LF++E +LK+ + G Y + +N FD V+ SI + ++
Sbjct: 1478 HGAPELYEAMLKHLNIVFTALFTLECILKIIAFGPLNYLKAAWNVFDFVTVLGSITDILV 1537
Query: 1663 VYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1842
K + +S LR R R+ K+ +
Sbjct: 1538 TEIKTDKLINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKGLPYVCLLIAMLFFIY 1597
Query: 1843 XXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIE------- 2001
GMQVFG P NF TF QAL+ +F+ TGE W+ +M +
Sbjct: 1598 AIIGMQVFGNIELNEETAINPHNNFRTFFQALMLLFRSATGEAWHEIMLSCLSNRPCDKL 1657
Query: 2002 SFGGVGTLGVIVCIYYIV--LFICGNYILLNVFLAIAVDN 2115
S G G +Y V +F+C ++++LN+F+A+ +DN
Sbjct: 1658 SGSGGKECGSDFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1696
Score = 46.6 bits (109), Expect = 0.007
Identities = 53/262 (20%), Positives = 103/262 (39%), Gaps = 3/262 (1%)
Frame = +1
Query: 2299 STVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANST 2478
++VK SS + R F +V F VL C++ + + A
Sbjct: 445 ASVKSSKLESSSYFRRKERRMRFFIRRMVKAQSFYWIVL-CLVGLNTLCVAIVHYDQPEW 503
Query: 2479 RNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFV--- 2649
L ++ F +F E++LK+ G ++ ++FN D V+ S+ V
Sbjct: 504 LTTGLYLAEFVFLGLFLSEMSLKMYGLGA----RNYFHSSFNCFDFSVIIGSILEVVWSM 559
Query: 2650 LRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAI 2829
++ A L+++V ++ ++K+I +++ + F+ +FA+
Sbjct: 560 IKPGASYGISVLRALRLLRLFKFTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFAL 619
Query: 2830 IGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAM 3009
+G+QLF G F ++E+ PT NFD A+
Sbjct: 620 LGMQLFGGQF-------------------NFEEETPTT-------------NFDTFPAAI 647
Query: 3010 ISLFVVSTFEGWPQLLYVAIDS 3075
+++F + T E W ++Y I+S
Sbjct: 648 LTVFQILTGEDWNAVMYHGIES 669
Score = 46.6 bits (109), Expect = 0.007
Identities = 48/227 (21%), Positives = 79/227 (34%), Gaps = 35/227 (15%)
Frame = +1
Query: 1534 FVILFSMEMLLKMYSLGFTTYTTSQF----NRFDCFVVISSILEFVLVYFDLMKPLGVSV 1701
F +F+ EM++KM LG + S F N D VV +++ F +
Sbjct: 1171 FTGVFTFEMVIKMIDLGLLLHPGSYFRDLWNILDFIVVSGALVAFACSGTKGKDINTIKS 1230
Query: 1702 LRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFN 1881
LR R+LR K K +Q+F GKF
Sbjct: 1231 LRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF 1290
Query: 1882 FNPQQPKP---------------------------RANFDTFVQALLTVFQILTGEDWNT 1980
+ + K ++D + A LT+F + TGE W
Sbjct: 1291 YCTDESKGLEKDCRGKFLDYDGDEVAAQDREWRKYEFHYDNVLWAFLTLFTVSTGEGWPM 1350
Query: 1981 VMYHGI----ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAV 2109
V+ H + E G + I+Y+V F+ + +N+F+A+ +
Sbjct: 1351 VLKHSVDATYEDEGPSPGFRMETSIFYVVYFVVFPFFFVNIFVALII 1397
>gi|6680822|ref|NP_031605.1| calcium channel, voltage-dependent, N
type, alpha 1B subunit; calcium channel,
voltage-dependent, L type, alpha 1B subunit [Mus
musculus]
gi|451659|gb|AAB60437.1| N-type calcium channel alpha1 subunit
Length = 2288
Score = 644 bits (1662), Expect = 0.0
Identities = 348/780 (44%), Positives = 479/780 (60%), Gaps = 8/780 (1%)
Frame = +1
Query: 2308 KPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNM 2487
+PI SS+F LS TN FR FC+ +V Y +L I +SS LAAEDP++ +S RN
Sbjct: 1110 RPIVPYSSMFCLSPTNLFRRFCHYIVTMRYLEMVILVVIALSSIALAAEDPVRTDSFRNN 1169
Query: 2488 ILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL---RT 2658
L Y DY FT VFT E+ +K+I GL+ H G++ R+ +N+LD +VV+ +L +F +
Sbjct: 1170 ALEYMDYIFTGVFTCEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKG 1229
Query: 2659 DAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGV 2838
++ I R LK V CV+ ++K + NI++V + F+FA+I V
Sbjct: 1230 KDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAV 1289
Query: 2839 QLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISL 3018
QLFKG FF C D SK E +CRG+Y+ YE + ++ R W DF++DNV A+++L
Sbjct: 1290 QLFKGKFFYCTDESKELERDCRGQYLDYEKEEVE---AQPRQWKKYDFHYDNVLWALLTL 1346
Query: 3019 FVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIVT 3198
F VST EGWP +L ++D+ E++GP R +++ +I+T
Sbjct: 1347 FTVSTGEGWPMVLKHSVDATYEEQGPSPGFRMELSILYVVYFVVFPFFFVNIFVALIIIT 1406
Query: 3199 FQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRAFEYVIF 3372
FQ +G++ C L+KN+R CI+FA+ AKP RY+P+N+ QY+ W FV S FEY I
Sbjct: 1407 FQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNKQSFQYKTWTFVVSPPFEYFIM 1466
Query: 3373 LIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVF 3552
+I +NTV L K Y + +E L N++FT +F+ E +LKI+A NY D WNVF
Sbjct: 1467 AMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECILKIIAFGVLNYFRDAWNVF 1526
Query: 3553 DLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQ 3732
D + V+GS DI ++ N I+++F RLFR RL+KLL +G IR LLWTF++SF+
Sbjct: 1527 DFVTVLGSITDILVTEIAETN-NFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFK 1585
Query: 3733 ALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAW 3912
ALPYV LLI +LFFIYA+IGMQ FG ALDD TSI+R+NNF +F AI++LFRSATGEAW
Sbjct: 1586 ALPYVCLLIAMLFFIYAIIGMQVFGNSALDDDTSINRHNNFRTFLQAIMLLFRSATGEAW 1645
Query: 3913 QDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVI 4092
+IMLSC D CDP + N S CG++FAY YF+SF LCSFL++NLFVAVI
Sbjct: 1646 HEIMLSCLDNR--ACDPHA--------NASECGSDFAYFYFVSFIFLCSFLMLNLFVAVI 1695
Query: 4093 MDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCP 4272
MDNF+YLTRD SILGPHHL+EF+R+W+EYDP A GRI + D+ +L+ +SPPLG GK CP
Sbjct: 1696 MDNFEYLTRDSSILGPHHLDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCP 1755
Query: 4273 HRLACKRLVSMNMPL-NSDGTVCFNATLFALVRTNLKIYTEGNIDEANEQLRSAIKRIWK 4449
R+A KRLV MNMP+ N D TV F +TL AL+RT L+I
Sbjct: 1756 ARVAYKRLVRMNMPISNEDMTVHFTSTLMALIRTALEI---------------------- 1793
Query: 4450 RTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEM--EAKGVLPAQTPQAM 4623
+ PA D++TVGK YA +I D++++ K ++ +A G L P ++
Sbjct: 1794 ---------KLAPA---DEMTVGKVYAALMIFDFYKQNKTTRDQTHQAPGGLSQMGPVSL 1841
Score = 506 bits (1304), Expect = e-141
Identities = 289/664 (43%), Positives = 371/664 (55%), Gaps = 24/664 (3%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N +RK I EW PFE++IL I ANCI LA+ Q P D + L+ E FI +
Sbjct: 81 DNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGI 140
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KI+A+GF+FH +YLRN WN++DF++V+ G+++T + FD++ LRA R
Sbjct: 141 FCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTD-----FDLRTLRAVR 195
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQVVL +I++AM+PLL I LL+ F IL++ IIGLE + GK H C
Sbjct: 196 VLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFGIIGLEFYMGKFHKACFP 255
Query: 760 PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFG 939
+T D PCG D A +C EC WPGPN GITNFDN
Sbjct: 256 NSTDTEPVGD-FPCGKDPP--ARQCDGDT---------ECREY--WPGPNFGITNFDNIL 301
Query: 940 LAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSK 1119
A+LTVFQC+++EGWTD++Y NDA G W W+YF+ L+I+GSFF+LNLVLGVLSGEF+K
Sbjct: 302 FAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAK 361
Query: 1120 EREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVAQTXXXXXXX 1299
ERE+ R F K R +QQ+E +L GYL+WI +AE++ ED+ +E
Sbjct: 362 ERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDKNAEEKSPLDVLKRAAT 421
Query: 1300 XXX------------------------XXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXL 1407
++ ++ +R EK+ +
Sbjct: 422 KKSRNDLIHAEEGEDRFVDLCAVGSPFARASLKSGKTESSSYFRRKEKM---FRFFIRRM 478
Query: 1408 VKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGF 1587
VK+Q+FYW HY Q + L A F+ LF EM LKMY LG
Sbjct: 479 VKAQSFYWVVLCVVALNTLCVAMVHYNQPQRLTTALYFAEFVFLGLFLTEMSLKMYGLGP 538
Query: 1588 TTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXX 1767
+Y S FN FD V++ SI E V G+SVLR+ RLLRIFKVTKYW
Sbjct: 539 RSYFRSSFNCFDFGVIVGSIFEVVWAAIKPGTSFGISVLRALRLLRIFKVTKYWNSLRNL 598
Query: 1768 XXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTV 1947
GMQ+FGG+FNF Q P FDTF A+LTV
Sbjct: 599 VVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF--QDETPTTIFDTFPAAILTV 656
Query: 1948 FQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADA 2127
FQILTGEDWN VMYHGIES GGV + G+ Y+IVL + GNY LLNVFLAIAVDNLA+A
Sbjct: 657 FQILTGEDWNAVMYHGIESQGGV-SKGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANA 715
Query: 2128 DSLT 2139
LT
Sbjct: 716 QELT 719
Score = 130 bits (328), Expect = 3e-28
Identities = 92/322 (28%), Positives = 160/322 (49%), Gaps = 10/322 (3%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
N R+ C IV + E +IL +I + IALA P + ++N LE ++Y+F VF
Sbjct: 1125 NLFRRFCHYIVTMRYLEMVILVVIALSSIALAAEDP--VRTDSFRNNALEYMDYIFTGVF 1182
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD-VKALRAFR 579
T E V+K++ +G + HP AY R+ WNILDFI+V LV+ S + + +K+LR R
Sbjct: 1183 TCEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLR 1242
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF GK C D
Sbjct: 1243 VLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF-YCTD 1301
Query: 760 PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFG 939
+ + ++D D E + QP +W+ ++DN
Sbjct: 1302 ES--KELERDCRGQYLDYEKEEVEAQPR--------QWKKYD-----------FHYDNVL 1340
Query: 940 LAMLTVFQCVSLEGWTDVMYWVNDAVGREWP---------WIYFVTLVILGSFFVLNLVL 1092
A+LT+F + EGW V+ DA E I +V ++ FF +N+ +
Sbjct: 1341 WALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGFRMELSILYVVYFVVFPFFFVNIFV 1400
Query: 1093 GVLSGEFSKEREKARARGLFQK 1158
++ F ++ +K + +K
Sbjct: 1401 ALIIITFQEQGDKVMSECSLEK 1422
Score = 119 bits (297), Expect = 1e-24
Identities = 80/293 (27%), Positives = 142/293 (48%), Gaps = 8/293 (2%)
Frame = +1
Query: 3268 FALKAKPHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFL 3447
F K K R +I R V +++F +V+ ++ +NT+ +A HY + L
Sbjct: 464 FRRKEKMFRFFIRR---------MVKAQSFYWVVLCVVALNTLCVAMVHYNQPQRLTTAL 514
Query: 3448 DVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLI 3627
+F G+F E LK+ L P++Y +N FD V+VGS ++ + + PG +
Sbjct: 515 YFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSIFEVVWAAIKPGTS--F 572
Query: 3628 SINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF- 3804
I+ R R++R+ K+ +R L+ + + S +++ + L+ L ++A++GMQ F
Sbjct: 573 GISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFG 632
Query: 3805 GKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYH- 3981
G+ D T F +FPAAIL +F+ TGE W +M YH
Sbjct: 633 GQFNFQDETP---TTIFDTFPAAILTVFQILTGEDWNAVM-----------------YHG 672
Query: 3982 ---KGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF---DYLTRD 4122
+GG+++ F+ YFI + ++ ++N+F+A+ +DN LT+D
Sbjct: 673 IESQGGVSKGM----FSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 721
Score = 93.6 bits (231), Expect = 5e-17
Identities = 73/297 (24%), Positives = 133/297 (44%), Gaps = 14/297 (4%)
Frame = +1
Query: 265 PFEFLILFMICANCIALAIYQPYPAQDSDYKNTL-LETIEYVFIVVFTIECVLKIVAMGF 441
PFE+ I+ MI N + L + D+ Y+ L L+ + VF +F++EC+LKI+A G
Sbjct: 1460 PFEYFIMAMIALNTVVLMM----KFYDAPYEYELMLKCLNIVFTSMFSMECILKIIAFGV 1515
Query: 442 MFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKALRAFRVLRPLRLVSGVP 615
+ Y R+AWN+ DF+ V+ + ++++++ ++ LR FR R ++L+
Sbjct: 1516 L----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGY 1571
Query: 616 SLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPT 795
+++++L +++ L ++ LL+ + IYAIIG+++F G A D T
Sbjct: 1572 TIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------GNSALDDDT 1618
Query: 796 PCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSL 975
N NF F A++ +F+ +
Sbjct: 1619 SI------------------------------------NRHNNFRTFLQAIMLLFRSATG 1642
Query: 976 EGWTDVMYWVND-----------AVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
E W ++M D G ++ + YFV+ + L SF +LNL + V+ F
Sbjct: 1643 EAWHEIMLSCLDNRACDPHANASECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1699
Score = 89.0 bits (219), Expect = 1e-15
Identities = 71/262 (27%), Positives = 117/262 (44%), Gaps = 13/262 (4%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLF+ S N R + + F +L I+ + +LA E L M L+
Sbjct: 74 SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 133
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV-----AVSLTSFVLRTDAM 2667
+ +F +F E +K+I G VFHKGS+ RN +N++D +VV A + T F LRT
Sbjct: 134 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDFDLRT--- 190
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
++ L+ V++ ++ A+ + I L+ F MF IIG++ +
Sbjct: 191 -----LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFGIIGLEFY 245
Query: 2848 KGTFFLCNDLSKMTEAECRGEYIHYEDGDPTK---PVSKKRVWSNNDF---NFDNVGDAM 3009
G F T+ E G++ +D + + W +F NFDN+ A+
Sbjct: 246 MGKFHKA-CFPNSTDTEPVGDFPCGKDPPARQCDGDTECREYWPGPNFGITNFDNILFAI 304
Query: 3010 ISLFVVSTFEGWPQLLYVAIDS 3075
+++F T EGW +LY D+
Sbjct: 305 LTVFQCITMEGWTDILYNTNDA 326
Score = 85.5 bits (210), Expect = 1e-14
Identities = 76/292 (26%), Positives = 122/292 (41%), Gaps = 42/292 (14%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY+I I+ N + LA + H P + LD F G+F FEA +KI+AL
Sbjct: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WNV D +VV+ G L GT+ + R RV+R +KL+S
Sbjct: 157 HKGSYLRNGWNVMDFVVVL-------TGILATAGTD-FDLRTLRAVRVLRPLKLVSGIPS 208
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQF----FGKVALDDSTSIH------- 3840
++ +L + MK+ L + LL+ ++ +IG++F F K +ST
Sbjct: 209 LQVVLKSIMKAMVPLLQIGLLLFFAILMFGIIGLEFYMGKFHKACFPNSTDTEPVGDFPC 268
Query: 3841 ------------------------RNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDRED 3948
NF + AIL +F+ T E W DI+ + +D
Sbjct: 269 GKDPPARQCDGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTND--- 325
Query: 3949 VRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
GN + + YFI ++ SF ++NL + V+ F
Sbjct: 326 ------------------AAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 359
Score = 72.4 bits (176), Expect = 1e-10
Identities = 51/205 (24%), Positives = 89/205 (42%), Gaps = 8/205 (3%)
Frame = +1
Query: 1525 NLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYF-DLMKPLGVSV 1701
N+ F +FSME +LK+ + G Y +N FD V+ SI + ++ + + +S
Sbjct: 1495 NIVFTSMFSMECILKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSF 1554
Query: 1702 LRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFN 1881
LR R R+ K+ + GMQVFG
Sbjct: 1555 LRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNSAL 1614
Query: 1882 FNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIES-----FGGVGTLGVIVCIY 2046
+ NF TF+QA++ +F+ TGE W+ +M +++ G +
Sbjct: 1615 DDDTSINRHNNFRTFLQAIMLLFRSATGEAWHEIMLSCLDNRACDPHANASECGSDFAYF 1674
Query: 2047 YIV--LFICGNYILLNVFLAIAVDN 2115
Y V +F+C ++++LN+F+A+ +DN
Sbjct: 1675 YFVSFIFLC-SFLMLNLFVAVIMDN 1698
Score = 70.1 bits (170), Expect = 6e-10
Identities = 107/560 (19%), Positives = 203/560 (36%), Gaps = 42/560 (7%)
Frame = +1
Query: 1534 FVILFSMEMLLKMYSLGFTTYTTSQF----NRFDCFVVISSILEFVLVYFDLMKPLGVSV 1701
F +F+ EM++KM LG + + F N D VV +++ F F K ++
Sbjct: 1178 FTGVFTCEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFA---FSGSKGKDINT 1234
Query: 1702 LRSARLLRIF---KVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGG 1872
++S R+LR+ K K +Q+F G
Sbjct: 1235 IKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKG 1294
Query: 1873 KFNFNPQQPK---------------------PRA------NFDTFVQALLTVFQILTGED 1971
KF + + K PR ++D + ALLT+F + TGE
Sbjct: 1295 KFFYCTDESKELERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEG 1354
Query: 1972 WNTVMYHGI----ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLT 2139
W V+ H + E G + + I Y+V F+ + +N+F+A+ + +
Sbjct: 1355 WPMVLKHSVDATYEEQGPSPGFRMELSILYVVYFVVFPFFFVNIFVALIIITFQEQGDKV 1414
Query: 2140 NAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSARPRRMSEVPAASTVKPIP 2319
+ S + + A + KP+
Sbjct: 1415 MSE------------------------------------CSLEKNERACIDFAISAKPLT 1438
Query: 2320 KASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMILNY 2499
+ ++ + SF+ V F ++ I +++ +L + A ++L
Sbjct: 1439 R----YMPQNKQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKF-YDAPYEYELMLKC 1493
Query: 2500 FDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSF----VLRTDAM 2667
+ FTS+F++E LK+I FG++ ++ R+A+N+ D + V S+T + T+
Sbjct: 1494 LNIVFTSMFSMECILKIIAFGVL----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNF 1549
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
+ + ++ ++ + + K + + L+ ML F++AIIG+Q+F
Sbjct: 1550 INLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1609
Query: 2848 KGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVV 3027
G L +D S N NF A++ LF
Sbjct: 1610 -GNSALDDDTS-----------------------------INRHNNFRTFLQAIMLLFRS 1639
Query: 3028 STFEGWPQLLYVAIDSNEED 3087
+T E W +++ +D+ D
Sbjct: 1640 ATGEAWHEIMLSCLDNRACD 1659
Score = 53.5 bits (127), Expect = 6e-05
Identities = 55/264 (20%), Positives = 104/264 (38%), Gaps = 3/264 (1%)
Frame = +1
Query: 2293 AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN 2472
A +++K SS + FR F +V F VL C++ + + A
Sbjct: 449 ARASLKSGKTESSSYFRRKEKMFRFFIRRMVKAQSFYWVVL-CVVALNTLCVAMVHYNQP 507
Query: 2473 STRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL 2652
L + ++ F +F E++LK+ G S+ R++FN D V+ S+ V
Sbjct: 508 QRLTTALYFAEFVFLGLFLTEMSLKMYGLG----PRSYFRSSFNCFDFGVIVGSIFEVVW 563
Query: 2653 RTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
K L+++V ++ ++K+I +++ + F+ +F
Sbjct: 564 AAIKPGTSFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVF 623
Query: 2824 AIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGD 3003
A++G+QLF G F +++D PT FD
Sbjct: 624 ALLGMQLFGGQF-------------------NFQDETPTT-------------IFDTFPA 651
Query: 3004 AMISLFVVSTFEGWPQLLYVAIDS 3075
A++++F + T E W ++Y I+S
Sbjct: 652 AILTVFQILTGEDWNAVMYHGIES 675
>gi|15127836|gb|AAK84311.1| high voltage-activated calcium channel
Cav2A [Schistosoma mansoni]
Length = 2203
Score = 641 bits (1654), Expect = 0.0
Identities = 351/789 (44%), Positives = 487/789 (61%), Gaps = 36/789 (4%)
Frame = +1
Query: 2308 KPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNM 2487
KP+ SS+FI S TN R FC+ VVN YF ++ I+ SS LAAEDP+ NS RN
Sbjct: 818 KPMLPYSSMFIFSSTNPVRRFCHFVVNLRYFDLFIMIVIVSSSLALAAEDPVSENSIRNC 877
Query: 2488 ILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSF----VLR 2655
+L YFD+ FT VF +E+ LK+I G+ H S+CR+ +NLLD VV +L SF L+
Sbjct: 878 LLEYFDHAFTCVFAIEMLLKLIDLGVFLHPYSYCRDTWNLLDAAVVIGALISFFRAYTLK 937
Query: 2656 TDA-------MSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQ 2814
A +S I R LK V CV+ ++K + I++V + Q
Sbjct: 938 GRAGHGSSKNLSTIKSLRVLRVLRPLKTIRRVPKLKAVFDCVVSSLKNVCIILVVYILFQ 997
Query: 2815 FMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDN 2994
F+F+I+ VQLF+G FF CNDLSK+T+ +C+G + Y+DG PV K RVWS+ DF++DN
Sbjct: 998 FIFSIVAVQLFQGKFFYCNDLSKLTKEDCQGYFFSYDDG--LVPVVKARVWSSRDFHYDN 1055
Query: 2995 VGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXX 3174
V AM++LF V+T EGWP +L ++D+ E + GP+ + Q +A+
Sbjct: 1056 VITAMLTLFTVTTGEGWPGILKNSMDATEVNHGPVEDHSQQMAIFYIIFFIVFPFFFVNI 1115
Query: 3175 XXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRN--RLQYRVWWFVTS 3348
+I+TFQ +GE E + ELDKNQ++CIEFA+ +KP RY+P N +YR+W V S
Sbjct: 1116 FVALIIITFQEQGENELVDHELDKNQKQCIEFAINSKPLCRYMPSNIASTKYRIWRLVVS 1175
Query: 3349 RAFEYVIFLIIVMNTVSLACKHY-----PSSRGFEDF-----------LDVFNLIFTGVF 3480
FEY I +I +NT+ L K+Y ++ G D+ L N FT +F
Sbjct: 1176 SPFEYYIMTMIALNTLILMMKYYRPDYTDANMGIPDWETQKYQSHCSTLVYLNTAFTAMF 1235
Query: 3481 AFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVM 3660
E +LK++A PK+Y D WN FD + VVGS D+ +L ++ +++ F RLFR
Sbjct: 1236 TMECLLKLIAFGPKSYFRDSWNTFDFITVVGSITDVLVSELQD--SSFLNLGFLRLFRAA 1293
Query: 3661 RLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTS-I 3837
RL+KL+ G IR LLWTF++SF+ALPYV LLI +LFFIYAV+GMQ FG +A +++ I
Sbjct: 1294 RLIKLIRHGYTIRILLWTFIQSFKALPYVCLLITMLFFIYAVVGMQIFGTIATNEAEGQI 1353
Query: 3838 HRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNES--RCG 4011
NNFHSFP A+L+LFR ATGE+WQ+IML+C+ Y + +N + CG
Sbjct: 1354 TSYNNFHSFPYAVLLLFRCATGESWQEIMLACT-------------YGQECVNRASNNCG 1400
Query: 4012 NNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDA 4191
+N +Y YF+SF CSFL++NLFVAVI+DNFDYLTRD ILG HHL+EF+R+W+EYDP A
Sbjct: 1401 SNASYTYFVSFNFFCSFLMLNLFVAVIVDNFDYLTRDSPILGSHHLDEFIRVWAEYDPGA 1460
Query: 4192 KGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRT 4371
KGRI + ++ +LRK+ PP+GFG+ CP+RLA K+L+ MNMPL+S GTV F TLFALVR
Sbjct: 1461 KGRIHYTEMYEMLRKLEPPVGFGQNCPYRLAYKKLIRMNMPLDSAGTVHFTTTLFALVRE 1520
Query: 4372 NL--KIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKE--DDVTVGKFYATFL 4539
+L K+ +D + +LR IK +W K LD ++PP + +TVGK YA L
Sbjct: 1521 SLGIKMAPAEFMDIKDAELRETIKTLWSVQAKRSLDLLLPPDSEYTFTRLTVGKIYAGLL 1580
Query: 4540 IQDYFRRFK 4566
I + ++ K
Sbjct: 1581 IYENWQMNK 1589
Score = 511 bits (1316), Expect = e-143
Identities = 289/665 (43%), Positives = 373/665 (55%), Gaps = 23/665 (3%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
NN IRK +I+EW PFE+++L I ANC+ LA+ P +D + LE E F+ +
Sbjct: 69 NNLIRKAARNIIEWGPFEYMVLSTIIANCVVLAMEVHLPNKDKRPLSEKLEITENYFLGI 128
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
FT E LKI+A+GF+ H +YLRN WNILDF++VV G ++ ++ S G +++ LRA R
Sbjct: 129 FTCEAFLKIIALGFILHSGSYLRNIWNILDFVVVVTGFLTMFMTSGS--GVNLRTLRAVR 186
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSGVPSLQVVL +I++AM PLL I +LVLF ILI+AI+GLE + G H TC +
Sbjct: 187 VLRPLKLVSGVPSLQVVLTSIIKAMAPLLQIGILVLFAILIFAIVGLEFYSGVFHVTCFE 246
Query: 760 PATGQLAQKDPT--PCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTT----WPGPNNGIT 921
Q +PT P CQP D+ T + C + W GPN GIT
Sbjct: 247 -------QSNPTELPSFIPDAPGLVPCQPVDTHTRPPGAFICPAGYICKGYWEGPNYGIT 299
Query: 922 NFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVL 1101
+FDN G AMLTVFQC+++EGWTDV+Y N G + WIYF+ L+++G+F ++NLVLGVL
Sbjct: 300 SFDNIGYAMLTVFQCITMEGWTDVLYMTNRTYGSRFNWIYFIPLIVIGAFLLINLVLGVL 359
Query: 1102 SGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNED----------- 1248
SGEF+KERE+ R F K R +QQ + +L GYLDWI +AE++ E
Sbjct: 360 SGEFAKERERVEKRRAFLKLRRQQQSDRELNGYLDWIQRAEEVILAEEQTSFAQRLNIIK 419
Query: 1249 -EQEDEPVAQTXXXXXXXXXXXXXXXXXXPSKWAARMK-----RLEKLNXXXXXXXXXLV 1410
+ E V + K K L + + L+
Sbjct: 420 ARKRAEKVRRRSNDAEKRAIAAELENCEAELKAKRNFKIPGSEALFQYHKRFRFAVRRLI 479
Query: 1411 KSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFT 1590
KSQ FY + E YGQ WL F + F+ LF EM++K+Y LG
Sbjct: 480 KSQKFYIIVITLVLLNALCVSVEFYGQPGWLTDFLYFSEFIFLGLFLFEMIIKIYGLGCL 539
Query: 1591 TYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXX 1770
Y S FN FD VV +S+ E V F G S LRS RLLRIFK+T+YW
Sbjct: 540 IYFHSTFNIFDFAVVFASLFEIVWQIFYPSDSFGFSALRSIRLLRIFKITRYWASLRNLV 599
Query: 1771 XXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVF 1950
GMQ+FGG+FNF+ KP NFDTFV+ALLTVF
Sbjct: 600 LSLLNAMRSILSLLFLLFLFMLIFALLGMQLFGGEFNFD--DGKPGQNFDTFVKALLTVF 657
Query: 1951 QILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADAD 2130
QILTGEDWN +MY GI S GGV G + CIY+++L + GNY LLNVFLAIAVDNLA+A
Sbjct: 658 QILTGEDWNMIMYDGIRSQGGVNNGGFVYCIYFVLLALFGNYTLLNVFLAIAVDNLANAQ 717
Query: 2131 SLTNA 2145
LT A
Sbjct: 718 ELTAA 722
Score = 115 bits (287), Expect = 2e-23
Identities = 86/321 (26%), Positives = 155/321 (47%), Gaps = 19/321 (5%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
NP+R+ C +V + F+ I+ +I ++ +ALA P ++ +N LLE ++ F VF
Sbjct: 833 NPVRRFCHFVVNLRYFDLFIMIVIVSSSLALAAEDP--VSENSIRNCLLEYFDHAFTCVF 890
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG----------F 552
IE +LK++ +G HP +Y R+ WN+LD VVIG + + +++G
Sbjct: 891 AIEMLLKLIDLGVFLHPYSYCRDTWNLLD-AAVVIGALISFFRAYTLKGRAGHGSSKNLS 949
Query: 553 DVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFC 732
+K+LR RVLRPL+ + VP L+ V + ++ ++ + I ++ + I++I+ ++LF
Sbjct: 950 TIKSLRVLRVLRPLKTIRRVPKLKAVFDCVVSSLKNVCIILVVYILFQFIFSIVAVQLFQ 1009
Query: 733 GKLHSTCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNN 912
GK C D +L ++ D +G F D L + SS
Sbjct: 1010 GKFF-YCND--LSKLTKE-------DCQGYFFSY--DDGLVPVVKARVWSSRD------- 1050
Query: 913 GITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAV---------GREWPWIYFVTLVILG 1065
++DN AMLT+F + EGW ++ DA + I+++ I+
Sbjct: 1051 --FHYDNVITAMLTLFTVTTGEGWPGILKNSMDATEVNHGPVEDHSQQMAIFYIIFFIVF 1108
Query: 1066 SFFVLNLVLGVLSGEFSKERE 1128
FF +N+ + ++ F ++ E
Sbjct: 1109 PFFFVNIFVALIIITFQEQGE 1129
Score = 108 bits (270), Expect = 1e-21
Identities = 75/296 (25%), Positives = 140/296 (46%), Gaps = 2/296 (0%)
Frame = +1
Query: 3220 EYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVS 3399
E ENCE + ++ F + + R ++ V + S+ F ++ ++++N +
Sbjct: 442 ELENCEAELKAKR--NFKIPGS-EALFQYHKRFRFAVRRLIKSQKFYIIVITLVLLNALC 498
Query: 3400 LACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSF 3579
++ + Y DFL IF G+F FE ++KI L Y +N+FD VV S
Sbjct: 499 VSVEFYGQPGWLTDFLYFSEFIFLGLFLFEMIIKIYGLGCLIYFHSTFNIFDFAVVFASL 558
Query: 3580 IDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLI 3759
+I + P ++ + R R++R+ K+ +R L+ + + + +++ + L+
Sbjct: 559 FEIVWQIFYP--SDSFGFSALRSIRLLRIFKITRYWASLRNLVLSLLNAMRSILSLLFLL 616
Query: 3760 VLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCS 3936
L I+A++GMQ F G+ DD NF +F A+L +F+ TGE W IM
Sbjct: 617 FLFMLIFALLGMQLFGGEFNFDDGKP---GQNFDTFVKALLTVFQILTGEDWNMIMY--- 670
Query: 3937 DREDVRCDPMSDDYHKGGLNESRCGNNFAY-PYFISFFMLCSFLVINLFVAVIMDN 4101
+ +R +GG+N F Y YF+ + ++ ++N+F+A+ +DN
Sbjct: 671 --DGIR--------SQGGVN----NGGFVYCIYFVLLALFGNYTLLNVFLAIAVDN 712
Score = 95.9 bits (237), Expect = 1e-17
Identities = 77/312 (24%), Positives = 138/312 (43%), Gaps = 24/312 (7%)
Frame = +1
Query: 250 IVEWKPFEFLILFMICANCIALAI--YQP--------YPAQDSDYKNTLLETIEYV---F 390
+V PFE+ I+ MI N + L + Y+P P ++ + T+ Y+ F
Sbjct: 1172 LVVSSPFEYYIMTMIALNTLILMMKYYRPDYTDANMGIPDWETQKYQSHCSTLVYLNTAF 1231
Query: 391 IVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGF-DVKAL 567
+FT+EC+LK++A G P +Y R++WN DFI VV + ++S++ F ++ L
Sbjct: 1232 TAMFTMECLLKLIAFG----PKSYFRDSWNTFDFITVVGSITDVLVSELQDSSFLNLGFL 1287
Query: 568 RAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHS 747
R FR R ++L+ +++++L +++ L ++ LL+ + IYA++G+++F +
Sbjct: 1288 RLFRAARLIKLIRHGYTIRILLWTFIQSFKALPYVCLLITMLFFIYAVVGMQIF----GT 1343
Query: 748 TCIDPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNF 927
+ A GQ+ NF
Sbjct: 1344 IATNEAEGQI--------------------------------------------TSYNNF 1359
Query: 928 DNFGLAMLTVFQCVSLEGWTDVMY-------WVNDA---VGREWPWIYFVTLVILGSFFV 1077
+F A+L +F+C + E W ++M VN A G + YFV+ SF +
Sbjct: 1360 HSFPYAVLLLFRCATGESWQEIMLACTYGQECVNRASNNCGSNASYTYFVSFNFFCSFLM 1419
Query: 1078 LNLVLGVLSGEF 1113
LNL + V+ F
Sbjct: 1420 LNLFVAVIVDNF 1431
Score = 90.9 bits (224), Expect = 3e-16
Identities = 68/268 (25%), Positives = 116/268 (42%), Gaps = 23/268 (8%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
+LF+ S N R ++ F VL I+ + +LA E L R + L
Sbjct: 62 ALFVFSKNNLIRKAARNIIEWGPFEYMVLSTIIANCVVLAMEVHLPNKDKRPLSEKLEIT 121
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSXXXX 2682
+ +F +FT E LK+I G + H GS+ RN +N+LD +VV + + + +
Sbjct: 122 ENYFLGIFTCEAFLKIIALGFILHSGSYLRNIWNILDFVVVVTGFLTMFMTSGSGVNLRT 181
Query: 2683 XXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFF 2862
++ L+ V+ +I A+ + I ++ +FAI+G++ + G F
Sbjct: 182 LRAVRVLRPLKLVSGVPSLQVVLTSIIKAMAPLLQIGILVLFAILIFAIVGLEFYSGVFH 241
Query: 2863 L-CNDLSKMTEAECRGEYIHYEDG-DPTKPVSK----------------KRVWSNNDF-- 2982
+ C + S TE +I G P +PV K W ++
Sbjct: 242 VTCFEQSNPTELP---SFIPDAPGLVPCQPVDTHTRPPGAFICPAGYICKGYWEGPNYGI 298
Query: 2983 -NFDNVGDAMISLFVVSTFEGWPQLLYV 3063
+FDN+G AM+++F T EGW +LY+
Sbjct: 299 TSFDNIGYAMLTVFQCITMEGWTDVLYM 326
Score = 86.3 bits (212), Expect = 8e-15
Identities = 82/345 (23%), Positives = 152/345 (43%), Gaps = 13/345 (3%)
Frame = +1
Query: 250 IVEWKPFEFLILFMICANCIALAI-YQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKI 426
+++ + F +++ ++ N + +++ + P +D+ L E++F+ +F E ++KI
Sbjct: 478 LIKSQKFYIIVITLVLLNALCVSVEFYGQPGWLTDF----LYFSEFIFLGLFLFEMIIKI 533
Query: 427 VAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKM-SIQGFDVKALRAFRVLRPLRLV 603
+G + Y + +NI DF +V L + F ALR+ R+LR ++
Sbjct: 534 YGLGCLI----YFHSTFNIFDFAVVFASLFEIVWQIFYPSDSFGFSALRSIRLLRIFKIT 589
Query: 604 SGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ 783
SL+ ++ ++L AM +L + L+ +LI+A++G++LF G+ + D GQ
Sbjct: 590 RYWASLRNLVLSLLNAMRSILSLLFLLFLFMLIFALLGMQLFGGEFNFD--DGKPGQ--- 644
Query: 784 KDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQ 963
NFD F A+LTVFQ
Sbjct: 645 ----------------------------------------------NFDTFVKALLTVFQ 658
Query: 964 CVSLEGWTDVMY-------WVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKE 1122
++ E W +MY VN+ G IYFV L + G++ +LN+ L + +
Sbjct: 659 ILTGEDWNMIMYDGIRSQGGVNN--GGFVYCIYFVLLALFGNYTLLNVFLAIAVDNLANA 716
Query: 1123 REKARA----RGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNE 1245
+E A + L + E+Q+ +E+LK L+ Q +I +NE
Sbjct: 717 QELTAAEEEEQRLANELAEQQEDKENLKTDLNQ-PQTIEINQINE 760
Score = 79.3 bits (194), Expect = 1e-12
Identities = 50/160 (31%), Positives = 89/160 (55%), Gaps = 7/160 (4%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY++ I+ N V LA + H P+ R + L++ F G+F EA LKI+AL
Sbjct: 85 FEYMVLSTIIANCVVLAMEVHLPNKDKRPLSEKLEITENYFLGIFTCEAFLKIIALGFIL 144
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WN+ D +VVV F +T + G NL ++ R RV+R +KL+S
Sbjct: 145 HSGSYLRNIWNILDFVVVVTGF--LTMFMTSGSGVNLRTL---RAVRVLRPLKLVSGVPS 199
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKV 3813
++ +L + +K+ L + +L++ I+A++G++F+ V
Sbjct: 200 LQVVLTSIIKAMAPLLQIGILVLFAILIFAIVGLEFYSGV 239
Score = 64.3 bits (155), Expect = 3e-08
Identities = 56/216 (25%), Positives = 88/216 (39%), Gaps = 9/216 (4%)
Frame = +1
Query: 1495 EWLDHFQTMA--NLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVY 1668
++ H T+ N F +F+ME LLK+ + G +Y +N FD V+ SI + ++
Sbjct: 1216 KYQSHCSTLVYLNTAFTAMFTMECLLKLIAFGPKSYFRDSWNTFDFITVVGSITDVLVSE 1275
Query: 1669 FDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1848
L + LR R R+ K+ ++
Sbjct: 1276 LQDSSFLNLGFLRLFRAARLIKLIRHGYTIRILLWTFIQSFKALPYVCLLITMLFFIYAV 1335
Query: 1849 XGMQVFGG-KFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMY---HGIESFG-G 2013
GMQ+FG N Q NF +F A+L +F+ TGE W +M +G E
Sbjct: 1336 VGMQIFGTIATNEAEGQITSYNNFHSFPYAVLLLFRCATGESWQEIMLACTYGQECVNRA 1395
Query: 2014 VGTLGVIVCIYYIVL--FICGNYILLNVFLAIAVDN 2115
G Y V F C ++++LN+F+A+ VDN
Sbjct: 1396 SNNCGSNASYTYFVSFNFFC-SFLMLNLFVAVIVDN 1430
Score = 57.4 bits (137), Expect = 4e-06
Identities = 53/257 (20%), Positives = 107/257 (41%), Gaps = 3/257 (1%)
Frame = +1
Query: 2314 IPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMIL 2493
IP + +LF + FR ++ F V+ +L+++ ++ E Q + L
Sbjct: 458 IPGSEALF--QYHKRFRFAVRRLIKSQKFYIIVITLVLLNALCVSVEFYGQPGWLTDF-L 514
Query: 2494 NYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDAMSX 2673
+ ++ F +F E+ +K+ G + + + FN+ D VV SL V + S
Sbjct: 515 YFSEFIFLGLFLFEMIIKIYGLGCLI----YFHSTFNIFDFAVVFASLFEIVWQIFYPSD 570
Query: 2674 XXXXXXXXXXXXXXAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQL 2844
+ L+++V ++ A+++I +++ + F+ +FA++G+QL
Sbjct: 571 SFGFSALRSIRLLRIFKITRYWASLRNLVLSLLNAMRSILSLLFLLFLFMLIFALLGMQL 630
Query: 2845 FKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFV 3024
F G F +++DG P + NFD A++++F
Sbjct: 631 FGGEF-------------------NFDDGKPGQ-------------NFDTFVKALLTVFQ 658
Query: 3025 VSTFEGWPQLLYVAIDS 3075
+ T E W ++Y I S
Sbjct: 659 ILTGEDWNMIMYDGIRS 675
Score = 48.1 bits (113), Expect = 0.002
Identities = 54/249 (21%), Positives = 93/249 (36%), Gaps = 44/249 (17%)
Frame = +1
Query: 1495 EWLDHFQTMANLFFVILFSMEMLLKMYSLGFT----TYTTSQFNRFDCFVVISSILEFVL 1662
E+ DH F +F++EMLLK+ LG +Y +N D VVI +++ F
Sbjct: 880 EYFDHA-------FTCVFAIEMLLKLIDLGVFLHPYSYCRDTWNLLDAAVVIGALISFFR 932
Query: 1663 VY-------FDLMKPLG-VSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXX 1818
Y K L + LR R+LR K +
Sbjct: 933 AYTLKGRAGHGSSKNLSTIKSLRVLRVLRPLKTIRRVPKLKAVFDCVVSSLKNVCIILVV 992
Query: 1819 XXXXXXXXXXXGMQVFGGKFNF--------------------NPQQPKPRA--------N 1914
+Q+F GKF + + P +A +
Sbjct: 993 YILFQFIFSIVAVQLFQGKFFYCNDLSKLTKEDCQGYFFSYDDGLVPVVKARVWSSRDFH 1052
Query: 1915 FDTFVQALLTVFQILTGEDWNTVMYHGIE----SFGGVGTLGVIVCIYYIVLFICGNYIL 2082
+D + A+LT+F + TGE W ++ + ++ + G V + I+YI+ FI +
Sbjct: 1053 YDNVITAMLTLFTVTTGEGWPGILKNSMDATEVNHGPVEDHSQQMAIFYIIFFIVFPFFF 1112
Query: 2083 LNVFLAIAV 2109
+N+F+A+ +
Sbjct: 1113 VNIFVALII 1121
>gi|631650|pir||S41080 calcium channel alpha-1 chain - mouse
Length = 2288
Score = 640 bits (1652), Expect = 0.0
Identities = 347/780 (44%), Positives = 478/780 (60%), Gaps = 8/780 (1%)
Frame = +1
Query: 2308 KPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNM 2487
+PI SS+F LS TN FR FC+ +V Y +L I +SS LAAEDP++ +S RN
Sbjct: 1110 RPIVPYSSMFCLSPTNLFRRFCHYIVTMRYLEMVILVVIALSSIALAAEDPVRTDSFRNN 1169
Query: 2488 ILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL---RT 2658
L Y DY FT VFT E+ +K+I GL+ H G++ R+ +N+LD +VV+ +L +F +
Sbjct: 1170 ALEYMDYIFTGVFTCEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKG 1229
Query: 2659 DAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGV 2838
++ I R LK V V+ ++K + NI++V + F+FA+I V
Sbjct: 1230 KDINTIKSLRVLRVLRPLKTIKRLPKLKPVFDSVVNSLKNVLNILIVYMLFMFIFAVIAV 1289
Query: 2839 QLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISL 3018
QLFKG FF C D SK E +CRG+Y+ YE + ++ R W DF++DNV A+++L
Sbjct: 1290 QLFKGKFFYCTDESKELERDCRGQYLDYEKEEVE---AQPRQWKKYDFHYDNVLWALLTL 1346
Query: 3019 FVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXXXXXXGFVIVT 3198
F VST EGWP +L ++D+ E++GP R +++ +I+T
Sbjct: 1347 FTVSTGEGWPMVLKHSVDATYEEQGPSPGFRMELSILYVVYFVVFPFFFVNIFVALIIIT 1406
Query: 3199 FQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFVTSRAFEYVIF 3372
FQ +G++ C L+KN+R CI+FA+ AKP RY+P+N+ QY+ W FV S FEY I
Sbjct: 1407 FQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNKQSFQYKTWTFVVSPPFEYFIM 1466
Query: 3373 LIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVF 3552
+I +NTV L K Y + +E L N++FT +F+ E +LKI+A NY D WNVF
Sbjct: 1467 AMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECILKIIAFGVLNYFRDAWNVF 1526
Query: 3553 DLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQ 3732
D + V+GS DI ++ N I+++F RLFR RL+KLL +G IR LLWTF++SF+
Sbjct: 1527 DFVTVLGSITDILVTEIAETN-NFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFK 1585
Query: 3733 ALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAW 3912
ALPYV LLI +LFFIYA+IGMQ FG ALDD TSI+R+NNF +F AI++LFRSATGEAW
Sbjct: 1586 ALPYVCLLIAMLFFIYAIIGMQVFGNSALDDDTSINRHNNFRTFLQAIMLLFRSATGEAW 1645
Query: 3913 QDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVI 4092
+IMLSC D CDP + N S CG++FAY YF+SF LCSFL++NLFVAVI
Sbjct: 1646 HEIMLSCLDNR--ACDPHA--------NASECGSDFAYFYFVSFIFLCSFLMLNLFVAVI 1695
Query: 4093 MDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCP 4272
MDNF+YLTRD SILGPHHL+EF+R+W+EYDP A GRI + D+ +L+ +SPPLG GK CP
Sbjct: 1696 MDNFEYLTRDSSILGPHHLDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCP 1755
Query: 4273 HRLACKRLVSMNMPL-NSDGTVCFNATLFALVRTNLKIYTEGNIDEANEQLRSAIKRIWK 4449
R+A KRLV MNMP+ N D TV F +TL AL+RT L+I
Sbjct: 1756 ARVAYKRLVRMNMPISNEDMTVHFTSTLMALIRTALEI---------------------- 1793
Query: 4450 RTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKEM--EAKGVLPAQTPQAM 4623
+ PA D++TVGK YA +I D++++ K ++ +A G L P ++
Sbjct: 1794 ---------KLAPA---DEMTVGKVYAALMIFDFYKQNKTTRDQTHQAPGGLSQMGPVSL 1841
Score = 506 bits (1304), Expect = e-141
Identities = 289/664 (43%), Positives = 371/664 (55%), Gaps = 24/664 (3%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+N +RK I EW PFE++IL I ANCI LA+ Q P D + L+ E FI +
Sbjct: 81 DNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGI 140
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 579
F E +KI+A+GF+FH +YLRN WN++DF++V+ G+++T + FD++ LRA R
Sbjct: 141 FCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTD-----FDLRTLRAVR 195
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+LVSG+PSLQVVL +I++AM+PLL I LL+ F IL++ IIGLE + GK H C
Sbjct: 196 VLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFGIIGLEFYMGKFHKACFP 255
Query: 760 PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFG 939
+T D PCG D A +C EC WPGPN GITNFDN
Sbjct: 256 NSTDTEPVGD-FPCGKDPP--ARQCDGDT---------ECREY--WPGPNFGITNFDNIL 301
Query: 940 LAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSK 1119
A+LTVFQC+++EGWTD++Y NDA G W W+YF+ L+I+GSFF+LNLVLGVLSGEF+K
Sbjct: 302 FAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAK 361
Query: 1120 EREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVAQTXXXXXXX 1299
ERE+ R F K R +QQ+E +L GYL+WI +AE++ ED+ +E
Sbjct: 362 ERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDKNAEEKSPLDVLKRAAT 421
Query: 1300 XXX------------------------XXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXL 1407
++ ++ +R EK+ +
Sbjct: 422 KKSRNDLIHAEEGEDRFVDLCAVGSPFARASLKSGKTESSSYFRRKEKM---FRFFIRRM 478
Query: 1408 VKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGF 1587
VK+Q+FYW HY Q + L A F+ LF EM LKMY LG
Sbjct: 479 VKAQSFYWVVLCVVALNTLCVAMVHYNQPQRLTTALYFAEFVFLGLFLTEMSLKMYGLGP 538
Query: 1588 TTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXX 1767
+Y S FN FD V++ SI E V G+SVLR+ RLLRIFKVTKYW
Sbjct: 539 RSYFRSSFNCFDFGVIVGSIFEVVWAAIKPGTSFGISVLRALRLLRIFKVTKYWNSLRNL 598
Query: 1768 XXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFNFNPQQPKPRANFDTFVQALLTV 1947
GMQ+FGG+FNF Q P FDTF A+LTV
Sbjct: 599 VVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF--QDETPTTIFDTFPAAILTV 656
Query: 1948 FQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADA 2127
FQILTGEDWN VMYHGIES GGV + G+ Y+IVL + GNY LLNVFLAIAVDNLA+A
Sbjct: 657 FQILTGEDWNAVMYHGIESQGGV-SKGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANA 715
Query: 2128 DSLT 2139
LT
Sbjct: 716 QELT 719
Score = 130 bits (327), Expect = 4e-28
Identities = 92/322 (28%), Positives = 161/322 (49%), Gaps = 10/322 (3%)
Frame = +1
Query: 223 NPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVF 402
N R+ C IV + E +IL +I + IALA P + ++N LE ++Y+F VF
Sbjct: 1125 NLFRRFCHYIVTMRYLEMVILVVIALSSIALAAEDP--VRTDSFRNNALEYMDYIFTGVF 1182
Query: 403 TIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD-VKALRAFR 579
T E V+K++ +G + HP AY R+ WNILDFI+V LV+ S + + +K+LR R
Sbjct: 1183 TCEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLR 1242
Query: 580 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCID 759
VLRPL+ + +P L+ V ++++ ++ +L+I ++ + + I+A+I ++LF GK C D
Sbjct: 1243 VLRPLKTIKRLPKLKPVFDSVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF-YCTD 1301
Query: 760 PATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFG 939
+ + ++D D E + QP +W+ ++DN
Sbjct: 1302 ES--KELERDCRGQYLDYEKEEVEAQPR--------QWKKYD-----------FHYDNVL 1340
Query: 940 LAMLTVFQCVSLEGWTDVMYWVNDAVGREWP---------WIYFVTLVILGSFFVLNLVL 1092
A+LT+F + EGW V+ DA E I +V ++ FF +N+ +
Sbjct: 1341 WALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGFRMELSILYVVYFVVFPFFFVNIFV 1400
Query: 1093 GVLSGEFSKEREKARARGLFQK 1158
++ F ++ +K + +K
Sbjct: 1401 ALIIITFQEQGDKVMSECSLEK 1422
Score = 119 bits (297), Expect = 1e-24
Identities = 80/293 (27%), Positives = 142/293 (48%), Gaps = 8/293 (2%)
Frame = +1
Query: 3268 FALKAKPHRRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFL 3447
F K K R +I R V +++F +V+ ++ +NT+ +A HY + L
Sbjct: 464 FRRKEKMFRFFIRR---------MVKAQSFYWVVLCVVALNTLCVAMVHYNQPQRLTTAL 514
Query: 3448 DVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLI 3627
+F G+F E LK+ L P++Y +N FD V+VGS ++ + + PG +
Sbjct: 515 YFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSIFEVVWAAIKPGTS--F 572
Query: 3628 SINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF- 3804
I+ R R++R+ K+ +R L+ + + S +++ + L+ L ++A++GMQ F
Sbjct: 573 GISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFG 632
Query: 3805 GKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYH- 3981
G+ D T F +FPAAIL +F+ TGE W +M YH
Sbjct: 633 GQFNFQDETP---TTIFDTFPAAILTVFQILTGEDWNAVM-----------------YHG 672
Query: 3982 ---KGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF---DYLTRD 4122
+GG+++ F+ YFI + ++ ++N+F+A+ +DN LT+D
Sbjct: 673 IESQGGVSKGM----FSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 721
Score = 93.6 bits (231), Expect = 5e-17
Identities = 73/297 (24%), Positives = 133/297 (44%), Gaps = 14/297 (4%)
Frame = +1
Query: 265 PFEFLILFMICANCIALAIYQPYPAQDSDYKNTL-LETIEYVFIVVFTIECVLKIVAMGF 441
PFE+ I+ MI N + L + D+ Y+ L L+ + VF +F++EC+LKI+A G
Sbjct: 1460 PFEYFIMAMIALNTVVLMM----KFYDAPYEYELMLKCLNIVFTSMFSMECILKIIAFGV 1515
Query: 442 MFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKALRAFRVLRPLRLVSGVP 615
+ Y R+AWN+ DF+ V+ + ++++++ ++ LR FR R ++L+
Sbjct: 1516 L----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGY 1571
Query: 616 SLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPT 795
+++++L +++ L ++ LL+ + IYAIIG+++F G A D T
Sbjct: 1572 TIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------GNSALDDDT 1618
Query: 796 PCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSL 975
N NF F A++ +F+ +
Sbjct: 1619 SI------------------------------------NRHNNFRTFLQAIMLLFRSATG 1642
Query: 976 EGWTDVMYWVND-----------AVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEF 1113
E W ++M D G ++ + YFV+ + L SF +LNL + V+ F
Sbjct: 1643 EAWHEIMLSCLDNRACDPHANASECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1699
Score = 89.0 bits (219), Expect = 1e-15
Identities = 71/262 (27%), Positives = 117/262 (44%), Gaps = 13/262 (4%)
Frame = +1
Query: 2329 SLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMI--LNYF 2502
SLF+ S N R + + F +L I+ + +LA E L M L+
Sbjct: 74 SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 133
Query: 2503 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVV-----AVSLTSFVLRTDAM 2667
+ +F +F E +K+I G VFHKGS+ RN +N++D +VV A + T F LRT
Sbjct: 134 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDFDLRT--- 190
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
++ L+ V++ ++ A+ + I L+ F MF IIG++ +
Sbjct: 191 -----LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFGIIGLEFY 245
Query: 2848 KGTFFLCNDLSKMTEAECRGEYIHYEDGDPTK---PVSKKRVWSNNDF---NFDNVGDAM 3009
G F T+ E G++ +D + + W +F NFDN+ A+
Sbjct: 246 MGKFHKA-CFPNSTDTEPVGDFPCGKDPPARQCDGDTECREYWPGPNFGITNFDNILFAI 304
Query: 3010 ISLFVVSTFEGWPQLLYVAIDS 3075
+++F T EGW +LY D+
Sbjct: 305 LTVFQCITMEGWTDILYNTNDA 326
Score = 85.5 bits (210), Expect = 1e-14
Identities = 76/292 (26%), Positives = 122/292 (41%), Gaps = 42/292 (14%)
Frame = +1
Query: 3355 FEYVIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVAL---- 3513
FEY+I I+ N + LA + H P + LD F G+F FEA +KI+AL
Sbjct: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
Query: 3514 NPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEG 3693
+ +Y+ + WNV D +VV+ G L GT+ + R RV+R +KL+S
Sbjct: 157 HKGSYLRNGWNVMDFVVVL-------TGILATAGTD-FDLRTLRAVRVLRPLKLVSGIPS 208
Query: 3694 IRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQF----FGKVALDDSTSIH------- 3840
++ +L + MK+ L + LL+ ++ +IG++F F K +ST
Sbjct: 209 LQVVLKSIMKAMVPLLQIGLLLFFAILMFGIIGLEFYMGKFHKACFPNSTDTEPVGDFPC 268
Query: 3841 ------------------------RNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDRED 3948
NF + AIL +F+ T E W DI+ + +D
Sbjct: 269 GKDPPARQCDGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTND--- 325
Query: 3949 VRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
GN + + YFI ++ SF ++NL + V+ F
Sbjct: 326 ------------------AAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 359
Score = 72.4 bits (176), Expect = 1e-10
Identities = 51/205 (24%), Positives = 89/205 (42%), Gaps = 8/205 (3%)
Frame = +1
Query: 1525 NLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYF-DLMKPLGVSV 1701
N+ F +FSME +LK+ + G Y +N FD V+ SI + ++ + + +S
Sbjct: 1495 NIVFTSMFSMECILKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSF 1554
Query: 1702 LRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGGKFN 1881
LR R R+ K+ + GMQVFG
Sbjct: 1555 LRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNSAL 1614
Query: 1882 FNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIES-----FGGVGTLGVIVCIY 2046
+ NF TF+QA++ +F+ TGE W+ +M +++ G +
Sbjct: 1615 DDDTSINRHNNFRTFLQAIMLLFRSATGEAWHEIMLSCLDNRACDPHANASECGSDFAYF 1674
Query: 2047 YIV--LFICGNYILLNVFLAIAVDN 2115
Y V +F+C ++++LN+F+A+ +DN
Sbjct: 1675 YFVSFIFLC-SFLMLNLFVAVIMDN 1698
Score = 70.1 bits (170), Expect = 6e-10
Identities = 107/560 (19%), Positives = 203/560 (36%), Gaps = 42/560 (7%)
Frame = +1
Query: 1534 FVILFSMEMLLKMYSLGFTTYTTSQF----NRFDCFVVISSILEFVLVYFDLMKPLGVSV 1701
F +F+ EM++KM LG + + F N D VV +++ F F K ++
Sbjct: 1178 FTGVFTCEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFA---FSGSKGKDINT 1234
Query: 1702 LRSARLLRIF---KVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGG 1872
++S R+LR+ K K +Q+F G
Sbjct: 1235 IKSLRVLRVLRPLKTIKRLPKLKPVFDSVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKG 1294
Query: 1873 KFNFNPQQPK---------------------PRA------NFDTFVQALLTVFQILTGED 1971
KF + + K PR ++D + ALLT+F + TGE
Sbjct: 1295 KFFYCTDESKELERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEG 1354
Query: 1972 WNTVMYHGI----ESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLT 2139
W V+ H + E G + + I Y+V F+ + +N+F+A+ + +
Sbjct: 1355 WPMVLKHSVDATYEEQGPSPGFRMELSILYVVYFVVFPFFFVNIFVALIIITFQEQGDKV 1414
Query: 2140 NAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTSARPRRMSEVPAASTVKPIP 2319
+ S + + A + KP+
Sbjct: 1415 MSE------------------------------------CSLEKNERACIDFAISAKPLT 1438
Query: 2320 KASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMILNY 2499
+ ++ + SF+ V F ++ I +++ +L + A ++L
Sbjct: 1439 R----YMPQNKQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKF-YDAPYEYELMLKC 1493
Query: 2500 FDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSF----VLRTDAM 2667
+ FTS+F++E LK+I FG++ ++ R+A+N+ D + V S+T + T+
Sbjct: 1494 LNIVFTSMFSMECILKIIAFGVL----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNF 1549
Query: 2668 SXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLF 2847
+ + ++ ++ + + K + + L+ ML F++AIIG+Q+F
Sbjct: 1550 INLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1609
Query: 2848 KGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVV 3027
G L +D S N NF A++ LF
Sbjct: 1610 -GNSALDDDTS-----------------------------INRHNNFRTFLQAIMLLFRS 1639
Query: 3028 STFEGWPQLLYVAIDSNEED 3087
+T E W +++ +D+ D
Sbjct: 1640 ATGEAWHEIMLSCLDNRACD 1659
Score = 53.5 bits (127), Expect = 6e-05
Identities = 55/264 (20%), Positives = 104/264 (38%), Gaps = 3/264 (1%)
Frame = +1
Query: 2293 AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN 2472
A +++K SS + FR F +V F VL C++ + + A
Sbjct: 449 ARASLKSGKTESSSYFRRKEKMFRFFIRRMVKAQSFYWVVL-CVVALNTLCVAMVHYNQP 507
Query: 2473 STRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL 2652
L + ++ F +F E++LK+ G S+ R++FN D V+ S+ V
Sbjct: 508 QRLTTALYFAEFVFLGLFLTEMSLKMYGLG----PRSYFRSSFNCFDFGVIVGSIFEVVW 563
Query: 2653 RTDAMSXXXXXXXXXXXXXXXAINRAK---GLKHVVQCVIVAVKTIGNIMLVTFMLQFMF 2823
K L+++V ++ ++K+I +++ + F+ +F
Sbjct: 564 AAIKPGTSFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVF 623
Query: 2824 AIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGD 3003
A++G+QLF G F +++D PT FD
Sbjct: 624 ALLGMQLFGGQF-------------------NFQDETPTT-------------IFDTFPA 651
Query: 3004 AMISLFVVSTFEGWPQLLYVAIDS 3075
A++++F + T E W ++Y I+S
Sbjct: 652 AILTVFQILTGEDWNAVMYHGIES 675
>gi|47225650|emb|CAG07993.1| unnamed protein product [Tetraodon
nigroviridis]
Length = 2336
Score = 638 bits (1646), Expect = 0.0
Identities = 349/815 (42%), Positives = 484/815 (58%), Gaps = 49/815 (6%)
Frame = +1
Query: 2278 MSEVPAASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAED 2457
+ E+ ASTV P +S+FI H N R C+ VVN YF ++L I SS LAAED
Sbjct: 1088 LDEMKPASTVVP----NSMFIFKHDNPVRRACHYVVNLRYFEMSILLVIAASSIALAAED 1143
Query: 2458 PLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSL 2637
P+ +S N +L YFDY FT VFT E+ +K+I GL+ H GS+ R+ +N+LD +VV +L
Sbjct: 1144 PVATSSDWNKVLRYFDYVFTGVFTFEMIIKMIDQGLILHDGSYFRDLWNILDFIVVVGAL 1203
Query: 2638 TSFVLRTDA---MSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFM 2808
+F L + + I R LK V CV+ ++K + NI++V +
Sbjct: 1204 VAFALSNNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKL 1263
Query: 2809 LQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNF 2988
F+FA+I VQLFKG FF C D SK TE EC+G YI Y K K+R W ++F++
Sbjct: 1264 FMFIFAVIAVQLFKGKFFYCTDSSKDTEKECQGYYIDY---GKDKKEMKRREWRRHEFHY 1320
Query: 2989 DNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALXXXXXXXXXXXXXX 3168
DNV A+++LF VS+ EGWPQ+L ++D EED+GP H +R +++
Sbjct: 1321 DNVMWALLTLFTVSSGEGWPQVLQHSVDVTEEDRGPSHGNRMEMSIFYVIYFVVFPFFFV 1380
Query: 3169 XXXXGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR--LQYRVWWFV 3342
+I+TFQ +G++ E C L+KN+R CI+FA+ AKP RY+P+NR QYR+W FV
Sbjct: 1381 NIFVALIIITFQEQGDKMMEECSLEKNERACIDFAISAKPLTRYMPQNRHTFQYRLWHFV 1440
Query: 3343 TSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPK 3522
S +FEY + +I +NT+ L K+Y + +E L N FT +F+ E +LKI+A
Sbjct: 1441 VSPSFEYTVLAMIALNTIVLMMKYYSAPPAYEAVLKHLNTAFTVIFSVECILKIMAFGFL 1500
Query: 3523 NYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRT 3702
NY D WN+FD + V+GS +I ++ + +++F +LFR RL+KLL +G IR
Sbjct: 1501 NYFRDTWNIFDFITVLGSITEII---VDLQSVDKFNMSFLKLFRAARLIKLLRQGYTIRI 1557
Query: 3703 LLWTFMKSFQALPYVALLIVLLFFIYAVIGMQF--------------------------- 3801
LLWTF++SF+ALPYV LLI +LFFIYA+IGMQ
Sbjct: 1558 LLWTFIQSFKALPYVCLLIAMLFFIYAIIGMQVRESNVASRNSADVEILIILVLFSFAQV 1617
Query: 3802 FGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDREDVRCDPM---SD 3972
FG + L D T I+++NNF +F A+L+LFRSATGE+WQ+IMLSC + DP SD
Sbjct: 1618 FGNIKLSDKTHINQHNNFKTFSGALLLLFRSATGESWQEIMLSCLGGQKCETDPAVPASD 1677
Query: 3973 DYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLE 4152
E CG++FAY YF+SF SFL++NLFVAVIMDNF+YLTRD SILGPHHL+
Sbjct: 1678 P-------EGGCGSDFAYFYFVSFIFFSSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLD 1730
Query: 4153 EFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGT 4332
EFVR+W EYD A GRI + D+ +L +SPPLG GK CP +LA KRLV MNMP++ D +
Sbjct: 1731 EFVRIWGEYDRAACGRIHYTDMYEMLTNMSPPLGLGKKCPSKLAYKRLVLMNMPVDEDMS 1790
Query: 4333 VCFNATLFALVRTNLKI--------------YTEGNIDEANEQLRSAIKRIWKRTHKDLL 4470
V F +TL AL+RT L + Y + ++ + L+ I IW + L
Sbjct: 1791 VHFTSTLMALIRTALDVKIARGWVTNQKFNMYGGEDRNQMDLDLQKEIGVIWPHLSQKSL 1850
Query: 4471 DEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRK 4575
D +V P K D+T+GK YA +I DY+++ K +K
Sbjct: 1851 DLLV-PIHKASDMTIGKIYAAMMIMDYYKQSKAKK 1884
Score = 303 bits (777), Expect = 2e-80
Identities = 156/315 (49%), Positives = 213/315 (67%)
Frame = +1
Query: 277 LILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPS 456
+IL I ANCI LA+ Q P +D + LE E FI +F E +KI+A+GF+FH
Sbjct: 1 MILTTIIANCIVLALEQHLPGEDKTPMSKRLEKTEPYFIGMFCFEAGIKIIALGFVFHKG 60
Query: 457 AYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLN 636
+YLRN WN++DFI+V+ G+++ + M+I D++ LRA RVLRPL+LVSG+PSLQ+VL
Sbjct: 61 SYLRNGWNVMDFIVVLSGILAAAGAHMNIS-VDLRTLRAVRVLRPLKLVSGIPSLQIVLK 119
Query: 637 AILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTE 816
+I++AM+PLL I LL+ F IL++AIIGLE + G+LH+TC + G L + D+
Sbjct: 120 SIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGRLHNTC-EARPGILENET-----VDSS 173
Query: 817 GSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVM 996
F C + R+ C TW GPN+GIT FDN A+LTVFQC+++EGWT V+
Sbjct: 174 ELEFPC----GVRQCPARYVCRD--TWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVL 227
Query: 997 YWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQQ 1176
Y +DA+G W W+YF+ L+I+GSFFVLNLVLGVLSGEF+KERE+ R F K R +QQ
Sbjct: 228 YNTDDALGPLWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMKLRRQQQ 287
Query: 1177 LEEDLKGYLDWITQA 1221
+E +L GY WI +A
Sbjct: 288 IERELNGYRAWIDRA 302
Score = 204 bits (518), Expect = 3e-50
Identities = 119/269 (44%), Positives = 145/269 (53%)
Frame = +1
Query: 1333 PSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXXXXXXXXXTSEHYGQSEWLDHF 1512
P+ + R +RL +++ +VK+QTFYW H+ Q WL F
Sbjct: 414 PTAYFRRKERLLRISIRR------VVKTQTFYWTVLGLVALNTLCVAIVHHNQPSWLSSF 467
Query: 1513 QTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLG 1692
A F+ LF EM LKMYSLG Y S FN FDC V++ SI E + +F G
Sbjct: 468 LYYAEFLFLALFLTEMFLKMYSLGPRLYFHSSFNCFDCSVIVGSIFEVLWGFFRPGTSFG 527
Query: 1693 VSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGMQVFGG 1872
+SVLR+ RLLRIFK+TKYW GMQ+FGG
Sbjct: 528 ISVLRALRLLRIFKITKYWASLRNLVVSLMNSMKSIISLIFLLFLFIVVFALLGMQLFGG 587
Query: 1873 KFNFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYI 2052
+F F P NFDTF A++TVFQILTGEDWN VMY GI S GGV + G+ IY+I
Sbjct: 588 RFIFEDYTP---TNFDTFPAAIMTVFQILTGEDWNEVMYDGIRSQGGVKS-GMWSSIYFI 643
Query: 2053 VLFICGNYILLNVFLAIAVDNLADADSLT 2139
VL + GNY LLNVFLAIAVDNLA+A LT
Sbjct: 644 VLTLFGNYTLLNVFLAIAVDNLANAQELT 672
Score = 159 bits (401), Expect = 1e-36
Identities = 161/681 (23%), Positives = 267/681 (38%), Gaps = 49/681 (7%)
Frame = +1
Query: 220 NNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVV 399
+NP+R+ C +V + FE IL +I A+ IALA P A SD+ N +L +YVF V
Sbjct: 1108 DNPVRRACHYVVNLRYFEMSILLVIAASSIALAAEDPV-ATSSDW-NKVLRYFDYVFTGV 1165
Query: 400 FTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFD-VKALRAF 576
FT E ++K++ G + H +Y R+ WNILDFI+VV LV+ LS + +K+LR
Sbjct: 1166 FTFEMIIKMIDQGLILHDGSYFRDLWNILDFIVVVGALVAFALSNNKGRDIKTIKSLRVL 1225
Query: 577 RVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI 756
RVLRPL+ + +P L+ V + ++ ++ + +I ++ + I+A+I ++LF GK C
Sbjct: 1226 RVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFY-CT 1284
Query: 757 DPATGQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNF 936
D + KD T+ E + M R W ++DN
Sbjct: 1285 D------SSKD-----TEKECQGYYIDYGKDKKEMKRR-------EW---RRHEFHYDNV 1323
Query: 937 GLAMLTVFQCVSLEGWTDVMYWVNDAV---------GREWPWIYFVTLVILGSFFVLNLV 1089
A+LT+F S EGW V+ D R I++V ++ FF +N+
Sbjct: 1324 MWALLTLFTVSSGEGWPQVLQHSVDVTEEDRGPSHGNRMEMSIFYVIYFVVFPFFFVNIF 1383
Query: 1090 LGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPV 1269
+ ++ F ++ +K E+ LE++ + +D+ A +P+ ++
Sbjct: 1384 VALIIITFQEQGDK---------MMEECSLEKNERACIDFAISA---KPLTRYMPQNRHT 1431
Query: 1270 AQTXXXXXXXXXXXXXXXXXXPSKWAARMKRLEKLNXXXXXXXXXLVKSQTFYWXXXXXX 1449
Q W V S +F +
Sbjct: 1432 FQYRL-------------------W-------------------HFVVSPSFEYTVLAMI 1453
Query: 1450 XXXXXXXTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCF 1629
++Y + N F ++FS+E +LK+ + GF Y +N FD
Sbjct: 1454 ALNTIVLMMKYYSAPPAYEAVLKHLNTAFTVIFSVECILKIMAFGFLNYFRDTWNIFDFI 1513
Query: 1630 VVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTXXXXXXXXXXXXXXXXXXX 1809
V+ SI E ++V + +S L+ R R+ K+ +
Sbjct: 1514 TVLGSITE-IIVDLQSVDKFNMSFLKLFRAARLIKLLRQGYTIRILLWTFIQSFKALPYV 1572
Query: 1810 XXXXXXXXXXXXXXGM---------------------------QVFGGKFNFNPQQPKPR 1908
GM QVFG +
Sbjct: 1573 CLLIAMLFFIYAIIGMQVRESNVASRNSADVEILIILVLFSFAQVFGNIKLSDKTHINQH 1632
Query: 1909 ANFDTFVQALLTVFQILTGEDWNTVMYH-----------GIESFGGVGTLGVIVCIYYIV 2055
NF TF ALL +F+ TGE W +M + + G G +Y V
Sbjct: 1633 NNFKTFSGALLLLFRSATGESWQEIMLSCLGGQKCETDPAVPASDPEGGCGSDFAYFYFV 1692
Query: 2056 LFI-CGNYILLNVFLAIAVDN 2115
FI ++++LN+F+A+ +DN
Sbjct: 1693 SFIFFSSFLMLNLFVAVIMDN 1713
Score = 117 bits (292), Expect = 4e-24
Identities = 72/265 (27%), Positives = 134/265 (50%), Gaps = 4/265 (1%)
Frame = +1
Query: 3340 VTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNP 3519
V ++ F + + ++ +NT+ +A H+ FL +F +F E LK+ +L P
Sbjct: 433 VKTQTFYWTVLGLVALNTLCVAIVHHNQPSWLSSFLYYAEFLFLALFLTEMFLKMYSLGP 492
Query: 3520 KNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIR 3699
+ Y +N FD V+VGS ++ +G PG + I+ R R++R+ K+ +R
Sbjct: 493 RLYFHSSFNCFDCSVIVGSIFEVLWGFFRPGTS--FGISVLRALRLLRIFKITKYWASLR 550
Query: 3700 TLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFF-GKVALDDSTSIHRNNNFHSFPAAI 3876
L+ + M S +++ + L+ L ++A++GMQ F G+ +D T NF +FPAAI
Sbjct: 551 NLVVSLMNSMKSIISLIFLLFLFIVVFALLGMQLFGGRFIFEDYTP----TNFDTFPAAI 606
Query: 3877 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLC 4056
+ +F+ TGE W ++M + +R +GG+ ++ YFI +
Sbjct: 607 MTVFQILTGEDWNEVMY-----DGIR--------SQGGVKSGM----WSSIYFIVLTLFG 649
Query: 4057 SFLVINLFVAVIMDNF---DYLTRD 4122
++ ++N+F+A+ +DN LT+D
Sbjct: 650 NYTLLNVFLAIAVDNLANAQELTKD 674
Score = 100 bits (248), Expect = 5e-19
Identities = 75/301 (24%), Positives = 137/301 (44%), Gaps = 19/301 (6%)
Frame = +1
Query: 268 FEFLILFMICANCIALAI--YQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGF 441
FE+ +L MI N I L + Y PA ++ +L+ + F V+F++EC+LKI+A GF
Sbjct: 1445 FEYTVLAMIALNTIVLMMKYYSAPPAYEA-----VLKHLNTAFTVIFSVECILKIMAFGF 1499
Query: 442 MFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSL 621
+ Y R+ WNI DFI V+ + I+ S+ F++ L+ FR R ++L+ ++
Sbjct: 1500 L----NYFRDTWNIFDFITVLGSITEIIVDLQSVDKFNMSFLKLFRAARLIKLLRQGYTI 1555
Query: 622 QVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQKDPTPC 801
+++L +++ L ++ LL+ + IYAIIG+++ +A ++
Sbjct: 1556 RILLWTFIQSFKALPYVCLLIAMLFFIYAIIGMQV------------RESNVASRN---- 1599
Query: 802 GTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEG 981
D E S + ++ ++ N NF F A+L +F+ + E
Sbjct: 1600 SADVEILIILVLFSFAQVFGNIKLSDKTHI------NQHNNFKTFSGALLLLFRSATGES 1653
Query: 982 WTDVMYWV-----------------NDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGE 1110
W ++M G ++ + YFV+ + SF +LNL + V+
Sbjct: 1654 WQEIMLSCLGGQKCETDPAVPASDPEGGCGSDFAYFYFVSFIFFSSFLMLNLFVAVIMDN 1713
Query: 1111 F 1113
F
Sbjct: 1714 F 1714
Score = 90.1 bits (222), Expect = 6e-16
Identities = 76/327 (23%), Positives = 146/327 (44%), Gaps = 15/327 (4%)
Frame = +1
Query: 250 IVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIV 429
+V+ + F + +L ++ N + +AI + ++ L E++F+ +F E LK+
Sbjct: 432 VVKTQTFYWTVLGLVALNTLCVAIVHH---NQPSWLSSFLYYAEFLFLALFLTEMFLKMY 488
Query: 430 AMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG--FDVKALRAFRVLRPLRLV 603
++G P Y +++N D V++G + +L G F + LRA R+LR ++
Sbjct: 489 SLG----PRLYFHSSFNCFD-CSVIVGSIFEVLWGFFRPGTSFGISVLRALRLLRIFKIT 543
Query: 604 SGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPATGQLAQ 783
SL+ ++ +++ +M ++ + L+ I+++A++G++LF G+
Sbjct: 544 KYWASLRNLVVSLMNSMKSIISLIFLLFLFIVVFALLGMQLFGGRF------------IF 591
Query: 784 KDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQ 963
+D TP TNFD F A++TVFQ
Sbjct: 592 EDYTP----------------------------------------TNFDTFPAAIMTVFQ 611
Query: 964 CVSLEGWTDVMYWVNDAVGRE-------WPWIYFVTLVILGSFFVLNLVLGVL------S 1104
++ E W +VMY D + + W IYF+ L + G++ +LN+ L + +
Sbjct: 612 ILTGEDWNEVMY---DGIRSQGGVKSGMWSSIYFIVLTLFGNYTLLNVFLAIAVDNLANA 668
Query: 1105 GEFSKEREKARARGLFQKFREKQQLEE 1185
E +K+ E+A A F EK L++
Sbjct: 669 QELTKDEEEAEA-----AFNEKHALQK 690
Score = 70.1 bits (170), Expect = 6e-10
Identities = 65/245 (26%), Positives = 109/245 (43%), Gaps = 13/245 (5%)
Frame = +1
Query: 2410 VLFCILVSSAMLAAEDPLQANSTRNMI--LNYFDYFFTSVFTVEITLKVIVFGLVFHKGS 2583
+L I+ + +LA E L M L + +F +F E +K+I G VFHKGS
Sbjct: 2 ILTTIIANCIVLALEQHLPGEDKTPMSKRLEKTEPYFIGMFCFEAGIKIIALGFVFHKGS 61
Query: 2584 FCRNAFNLLDILVVAVSLTSFVLRTDA-MSXXXXXXXXXXXXXXXAINRAKG---LKHVV 2751
+ RN +N++D +VV L+ + A M+ + G L+ V+
Sbjct: 62 YLRNGWNVMDFIVV---LSGILAAAGAHMNISVDLRTLRAVRVLRPLKLVSGIPSLQIVL 118
Query: 2752 QCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFF-LCNDLSKMTEAE-CRGEYIHYE 2925
+ ++ A+ + I L+ F MFAIIG++ + G C + E E + +
Sbjct: 119 KSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGRLHNTCEARPGILENETVDSSELEFP 178
Query: 2926 DG---DPTKPVSKKRVWSNND--FNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDK 3090
G P + V + ND FDN+ A++++F T EGW +LY + ++
Sbjct: 179 CGVRQCPARYVCRDTWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLY----NTDDAL 234
Query: 3091 GPIHN 3105
GP+ N
Sbjct: 235 GPLWN 239
Score = 67.4 bits (163), Expect = 4e-09
Identities = 67/291 (23%), Positives = 117/291 (40%), Gaps = 44/291 (15%)
Frame = +1
Query: 3364 VIFLIIVMNTVSLACK-HYPSS--RGFEDFLDVFNLIFTGVFAFEAVLKIVAL----NPK 3522
+I I+ N + LA + H P L+ F G+F FEA +KI+AL +
Sbjct: 1 MILTTIIANCIVLALEQHLPGEDKTPMSKRLEKTEPYFIGMFCFEAGIKIIALGFVFHKG 60
Query: 3523 NYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRT 3702
+Y+ + WNV D +VV+ + +N + + R RV+R +KL+S ++
Sbjct: 61 SYLRNGWNVMDFIVVLSGILAAAGAHMNIS----VDLRTLRAVRVLRPLKLVSGIPSLQI 116
Query: 3703 LLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFG---------------KVALDDS--- 3828
+L + MK+ L + LL+ ++A+IG++F+ +D S
Sbjct: 117 VLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGRLHNTCEARPGILENETVDSSELE 176
Query: 3829 ----------------TSIHRNN---NFHSFPAAILVLFRSATGEAWQDIMLSCSDREDV 3951
T I N+ F + A+L +F+ T E W ++ + D
Sbjct: 177 FPCGVRQCPARYVCRDTWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTDD---- 232
Query: 3952 RCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVIMDNF 4104
G + + YFI ++ SF V+NL + V+ F
Sbjct: 233 -----------------ALGPLWNWLYFIPLIIIGSFFVLNLVLGVLSGEF 266
Score = 50.1 bits (118), Expect = 6e-04
Identities = 58/283 (20%), Positives = 112/283 (39%), Gaps = 5/283 (1%)
Frame = +1
Query: 2293 AASTVKPIPKASSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQAN 2472
A ++++ + + + R+ VV F VL + +++ +A Q
Sbjct: 403 ARASIRSAKRGPTAYFRRKERLLRISIRRVVKTQTFYWTVLGLVALNTLCVAIVHHNQP- 461
Query: 2473 STRNMILNYFDYFFTSVFTVEITLKVIVFG--LVFHKGSFCRNAFNLLDILVVAVSLTSF 2646
S + L Y ++ F ++F E+ LK+ G L FH ++FN D V+ S+
Sbjct: 462 SWLSSFLYYAEFLFLALFLTEMFLKMYSLGPRLYFH------SSFNCFDCSVIVGSIFEV 515
Query: 2647 V---LRTDAMSXXXXXXXXXXXXXXXAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQF 2817
+ R L+++V ++ ++K+I +++ + F+
Sbjct: 516 LWGFFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMNSMKSIISLIFLLFLFIV 575
Query: 2818 MFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNV 2997
+FA++G+QLF G F +ED PT NFD
Sbjct: 576 VFALLGMQLFGGRFI-------------------FEDYTPT--------------NFDTF 602
Query: 2998 GDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVAL 3126
A++++F + T E W +++Y I S K + +S + L
Sbjct: 603 PAAIMTVFQILTGEDWNEVMYDGIRSQGGVKSGMWSSIYFIVL 645
Score = 46.2 bits (108), Expect = 0.009
Identities = 23/63 (36%), Positives = 38/63 (59%)
Frame = +1
Query: 1915 FDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVF 2094
FD + A+LTVFQ +T E W TV+Y+ ++ G + +Y+I L I G++ +LN+
Sbjct: 204 FDNILFAVLTVFQCITMEGWTTVLYNTDDALGPLWN-----WLYFIPLIIIGSFFVLNLV 258
Query: 2095 LAI 2103
L +
Sbjct: 259 LGV 261