Homology by BLASTX
BLASTX 2.2.4 [Aug-26-2002]
Query= C51E3_10
(1959 letters)
Database: /home/niguts/usr02/tshini/ykclst/db/nr.seq
1,967,186 sequences; 661,712,633 total letters
Score E
Sequences producing significant alignments: (bits) Value
gi|25146341|ref|NP_505614.2| EGg Laying defective EGL-3, Kex-2 P... 1329 0.0
gi|14537990|gb|AAK66762.1| proprotein convertase 2 [Heterodera g... 1008 0.0
gi|25289986|pir||C89181 protein C51E3.7b [imported] - Caenorhabd... 939 0.0
gi|39593278|emb|CAE64748.1| Hypothetical protein CBG09536 [Caeno... 917 0.0
gi|13506775|gb|AAK28328.1| PC2-like protein [Orconectes limosus] 840 0.0
gi|17136192|ref|NP_477318.1| CG6438-PA [Drosophila melanogaster]... 816 0.0
gi|5732438|gb|AAD49105.1| prohormone and neuropeptide processing... 815 0.0
gi|31198129|ref|XP_308012.1| ENSANGP00000019377 [Anopheles gambi... 815 0.0
gi|1620966|emb|CAA70106.1| PC2-like prohormone convertase [Lucil... 811 0.0
gi|48095938|ref|XP_392366.1| similar to PC2-like prohormone conv... 763 0.0
gi|280683|pir||S23118 proprotein convertase 2 (EC 3.4.21.94) pre... 725 0.0
gi|49256229|gb|AAH74270.1| Unknown (protein for MGC:84034) [Xeno... 724 0.0
gi|49257870|gb|AAH74387.1| Pcsk2-A protein [Xenopus laevis] 722 0.0
gi|542504|pir||S40449 proprotein convertase 2 (EC 3.4.21.94) pre... 717 0.0
gi|37360779|dbj|BAC98351.1| prohormone convertase 2 [Rana catesb... 716 0.0
gi|847759|gb|AAA87005.1| subtilisin-related protease SPC2 [Branc... 716 0.0
gi|189652|gb|AAA60032.1| endoprotease 715 0.0
gi|46092402|dbj|BAD14307.1| proprotein convertase type 2 [Oryzia... 715 0.0
gi|417351|sp|Q03333|NEC2_PIG NEUROENDOCRINE CONVERTASE 2 PRECURS... 715 0.0
gi|20336244|ref|NP_002585.2| proprotein convertase subtilisin/ke... 714 0.0
gi|30584695|gb|AAP36600.1| Homo sapiens proprotein convertase su... 714 0.0
gi|283589|pir||S27270 proprotein convertase 2 (EC 3.4.21.94) pre... 714 0.0
gi|383113|prf||1902230A prohormone convertase 712 0.0
gi|416483|emb|CAA42204.1| prepro-hormone convertase 2 [Aplysia c... 712 0.0
gi|453663|gb|AAA27769.1| PC2 712 0.0
gi|26252123|gb|AAH40546.1| PCSK2 protein [Homo sapiens] 711 0.0
gi|3694954|gb|AAC62503.1| proprotein convertase PC2 precursor [R... 710 0.0
gi|47223236|emb|CAF98620.1| unnamed protein product [Tetraodon n... 710 0.0
gi|6679229|ref|NP_032818.1| proprotein convertase subtilisin/kex... 708 0.0
gi|6981342|ref|NP_036878.1| proprotein convertase subtilisin/kex... 707 0.0
gi|27806047|ref|NP_776838.1| proprotein convertase subtilisin/ke... 705 0.0
gi|205065|gb|AAA41477.1| ORF with similarities to Kex2 and furin... 701 0.0
gi|21832168|dbj|BAC05491.1| prohormone convertase 2 [Halocynthia... 701 0.0
gi|50738915|ref|XP_419332.1| PREDICTED: similar to Neuroendocrin... 655 0.0
gi|7671610|emb|CAB89428.1| dJ531H16.1 (proprotein convertase sub... 583 e-165
gi|30983812|gb|AAP41214.1| PC2 [Haliotis rubra] 559 e-158
gi|44885320|dbj|BAD11989.1| furin endoprotease [Oryzias latipes] 475 e-132
gi|45382645|ref|NP_990046.1| trans Golgi network protease furin ... 474 e-132
gi|27806495|ref|NP_776561.1| paired basic amino acid cleaving en... 472 e-131
gi|120612|sp|P23188|FURI_MOUSE Furin precursor (Paired basic ami... 470 e-131
gi|34857161|ref|XP_346547.1| hypothetical protein XP_346546 [Rat... 470 e-131
gi|6754996|ref|NP_035176.1| furin (paired basic amino acid cleav... 470 e-131
gi|671690|gb|AAB60516.1| furin endoprotease 468 e-130
gi|9506955|ref|NP_062204.1| proprotein convertase subtilisin/kex... 468 e-130
gi|4505579|ref|NP_002560.1| furin preproprotein; proprotein conv... 466 e-130
gi|5532442|gb|AAD44728.1| furin1-X [Lymnaea stagnalis] 463 e-129
gi|790671|gb|AAA73903.1| furin-like prohormone convertase [Aplys... 459 e-128
gi|50414709|gb|AAH77263.1| LOC397747 protein [Xenopus laevis] 458 e-127
gi|120608|sp|P29119|FUR1_XENLA FURIN 1 PRECURSOR (PAIRED BASIC A... 457 e-127
gi|847761|gb|AAA87006.1| subtilisin-related protease SPC3 [Branc... 455 e-126
gi|671688|gb|AAA87178.1| truncated furin endoprotease 455 e-126
gi|453659|gb|AAA27767.1| PC1A 454 e-126
gi|453657|gb|AAA51405.1| FUR 452 e-125
gi|7511798|pir||T30347 vitellogenin convertase - yellow fever mo... 451 e-125
gi|37196912|dbj|BAC97793.1| furin-like convetase [Bombyx mori] 451 e-125
gi|39588954|emb|CAE69584.1| Hypothetical protein CBG15803 [Caeno... 451 e-125
gi|47230351|emb|CAF99544.1| unnamed protein product [Tetraodon n... 451 e-125
gi|555516|gb|AAA49718.1| furin 451 e-125
gi|104052|pir||B41627 furin (EC 3.4.21.75) 18 precursor - Africa... 451 e-125
gi|25141268|ref|NP_492974.2| kex-2 Proprotein Convertase, furin ... 450 e-125
gi|2281777|dbj|BAA21626.1| PACE4E-II [Homo sapiens] 449 e-125
gi|2281778|dbj|BAA21627.1| PACE4E-I [Homo sapiens] 449 e-125
gi|2281776|dbj|BAA21625.1| PACE4A-II [Homo sapiens] 449 e-125
gi|2281775|dbj|BAA21624.1| PACE4A-I [Homo sapiens] 449 e-125
gi|7435771|pir||JC5571 subtilisin-like proprotein convertase (EC... 449 e-124
gi|20336184|ref|NP_612194.1| paired basic amino acid cleaving sy... 449 e-124
gi|7435770|pir||JC5570 subtilisin-like proprotein convertase (EC... 449 e-124
gi|20336182|ref|NP_612193.1| paired basic amino acid cleaving sy... 449 e-124
gi|20336180|ref|NP_612192.1| paired basic amino acid cleaving sy... 449 e-124
gi|4505577|ref|NP_002561.1| paired basic amino acid cleaving sys... 449 e-124
gi|2264334|gb|AAB63525.1| celfur protein 448 e-124
gi|6981328|ref|NP_037131.1| subtilisin - like endoprotease [Ratt... 446 e-124
gi|7435772|pir||I52527 PACE4A - mouse (fragment) >gnl|BL_ORD_ID|... 446 e-124
gi|630804|pir||S43656 furin (EC 3.4.21.75) 2 - great pond snail ... 445 e-123
gi|17864552|ref|NP_524885.1| CG10772-PB [Drosophila melanogaster... 444 e-123
gi|7435768|pir||G02428 subtilisin-like proprotein convertase (EC... 443 e-123
gi|20336246|ref|NP_006191.2| proprotein convertase subtilisin/ke... 442 e-122
gi|127999|sp|P29120|NEC1_HUMAN Neuroendocrine convertase 1 precu... 442 e-122
gi|50055|emb|CAA40368.1| serine protease AtT-1 [Mus musculus] 442 e-122
gi|24650056|ref|NP_733102.1| CG10772-PA [Drosophila melanogaster... 441 e-122
gi|157242|gb|AAA28467.1| dKLIP-1 441 e-122
gi|12643982|sp|P41413|PCK5_RAT Proprotein convertase subtilisin/... 441 e-122
gi|20336242|ref|NP_000430.3| proprotein convertase subtilisin/ke... 441 e-122
gi|45553515|ref|NP_996294.1| CG10772-PE [Drosophila melanogaster... 441 e-122
gi|34861684|ref|XP_342033.1| proprotein convertase subtilisin/ke... 441 e-122
gi|24650058|ref|NP_733103.1| CG10772-PC [Drosophila melanogaster... 441 e-122
gi|20886821|ref|XP_129214.1| proprotein convertase subtilisin/ke... 441 e-122
gi|12644383|sp|Q04592|PCK5_MOUSE Proprotein convertase subtilisi... 441 e-122
gi|12643790|sp|Q92824|PCK5_HUMAN Proprotein convertase subtilisi... 441 e-122
gi|15341799|gb|AAH13068.1| Pcsk5 protein [Mus musculus] 441 e-122
gi|539917|pir||A48225 subtilisin-like proprotein convertase (EC ... 441 e-122
gi|7435769|pir||JC6148 subtilisin-like proprotein convertase (EC... 440 e-122
gi|128000|sp|P21662|NEC1_MOUSE Neuroendocrine convertase 1 precu... 439 e-122
gi|7305371|ref|NP_038656.1| proprotein convertase subtilisin/kex... 439 e-122
gi|33357981|pdb|1P8J|A Chain A, Crystal Structure Of The Proprot... 439 e-121
gi|7435766|pir||S71340 kexin-like proteinase (EC 3.4.21.-) precu... 439 e-121
gi|1660988|dbj|BAA11133.1| prohormone convertase 3 [Homo sapiens] 438 e-121
gi|404642|gb|AAA03337.1| endopeptidase PC1 438 e-121
gi|47522896|ref|NP_999203.1| prohormone convertase [Sus scrofa] ... 437 e-121
gi|205063|gb|AAA41476.1| ORF with similarities to Kex2 and furin... 437 e-121
gi|27806045|ref|NP_776837.1| proprotein convertase subtilisin/ke... 437 e-121
gi|20336190|ref|NP_612197.1| paired basic amino acid cleaving sy... 437 e-121
gi|27894285|ref|NP_612198.2| paired basic amino acid cleaving sy... 437 e-121
gi|20336188|ref|NP_612196.1| paired basic amino acid cleaving sy... 437 e-121
gi|11359826|pir||T43251 furin (EC 3.4.21.75) - fall armyworm >gn... 436 e-120
gi|8393919|ref|NP_058787.1| proprotein convertase subtilisin/kex... 436 e-120
gi|31242769|ref|XP_321815.1| ENSANGP00000020254 [Anopheles gambi... 429 e-118
gi|37360777|dbj|BAC98350.1| prohormone convertase 1 [Rana catesb... 427 e-118
gi|1587135|prf||2206277A pro-hormone-converting enzyme PC2 427 e-118
gi|33469095|ref|NP_032819.1| proprotein convertase subtilisin/ke... 425 e-117
gi|24642484|ref|NP_727963.1| CG18734-PA [Drosophila melanogaster... 422 e-116
gi|37183044|gb|AAQ89322.1| prohormone convertase [Homo sapiens] 422 e-116
gi|283646|pir||A43434 furin (EC 3.4.21.75) 2 - fruit fly (Drosop... 422 e-116
gi|24642490|ref|NP_523368.2| CG18734-PD [Drosophila melanogaster... 422 e-116
gi|1083468|pir||A54306 proprotein convertase 4 (EC 3.4.21.-) pre... 422 e-116
gi|2118124|pir||I77530 proprotein convertase 4 (EC 3.4.21.-) pre... 421 e-116
gi|294608|gb|AAA41814.1| proprotein convertase 4 [Rattus norvegi... 421 e-116
gi|19424240|ref|NP_598243.1| proprotein convertase subtilisin/ke... 421 e-116
gi|1173877|gb|AAB06591.1| prohormone convertase 1 418 e-115
gi|6715146|gb|AAF26302.1| proprotein convertase aPC6C isoform [B... 417 e-115
gi|12643811|sp|Q9NJ15|PCK5_BRACL Proprotein convertase subtilisi... 417 e-115
gi|6715142|gb|AAF26300.1| proprotein convertase aPC6A isoform [B... 417 e-115
gi|3694874|gb|AAC62483.1| prohormone convertase 1 precursor [Ran... 416 e-114
gi|453661|gb|AAA27768.1| PC1B 409 e-112
gi|507306|gb|AAA39973.1| proprotein convertase 4 [Mus musculus] 409 e-112
gi|48098023|ref|XP_393955.1| similar to Furin-like protease 1, i... 409 e-112
gi|128013|sp|P29145|NECB_HYDAT PC3-like endoprotease variant B p... 407 e-112
gi|422325|pir||B46184 proprotein convertase 1 (EC 3.4.21.93) pre... 407 e-112
gi|128011|sp|P29146|NECA_HYDAT PC3-like endoprotease variant A p... 407 e-112
gi|48094641|ref|XP_392159.1| similar to Endoprotease FURIN [Apis... 407 e-112
gi|31206075|ref|XP_311989.1| ENSANGP00000018567 [Anopheles gambi... 407 e-112
gi|47219823|emb|CAG03450.1| unnamed protein product [Tetraodon n... 406 e-112
gi|22766922|gb|AAH37450.1| Pace4 protein [Mus musculus] 405 e-111
gi|32527514|gb|AAO12507.1| blisterase precursor [Onchocerca volv... 405 e-111
gi|631851|pir||JC2345 kexin-like proteinase (EC 3.4.21.-) PC7B p... 404 e-111
gi|631850|pir||JC2346 kexin-like proteinase (EC 3.4.21.-) PC7A p... 404 e-111
gi|23266416|gb|AAN10146.1| serine protease PC5-A [Rana esculenta] 403 e-111
gi|38088148|ref|XP_133531.2| similar to PACE4A [Mus musculus] 394 e-108
gi|47215190|emb|CAG01397.1| unnamed protein product [Tetraodon n... 393 e-108
gi|17944260|gb|AAL48024.1| LD30182p [Drosophila melanogaster] 390 e-107
gi|2281773|dbj|BAA21622.1| PACE4D [Homo sapiens] 389 e-106
gi|625421|pir||JC2192 subtilisin-like proprotein convertase (EC ... 389 e-106
gi|39595663|emb|CAE67165.1| Hypothetical protein CBG12593 [Caeno... 365 3e-99
gi|459699|gb|AAA98750.1| endoprotease 364 5e-99
gi|22096331|sp|P51559|BLI4_CAEEL Endoprotease bli-4 precursor (B... 364 5e-99
gi|459701|gb|AAA98751.1| endoprotease 364 5e-99
gi|32562849|ref|NP_491830.2| kex-2 Proprotein Convertase, endopr... 363 1e-98
gi|32562847|ref|NP_491829.3| kex-2 Proprotein Convertase, endopr... 363 1e-98
gi|25289984|pir||E87803 protein bli-4E [imported] - Caenorhabdit... 362 1e-98
gi|2773242|gb|AAB96753.1| Blistered cuticle protein 4, isoform a... 362 1e-98
gi|2773246|gb|AAB96757.1| Blistered cuticle protein 4, isoform c... 362 1e-98
gi|27374468|gb|AAO12410.1| Blistered cuticle protein 4, isoform ... 362 1e-98
gi|32562845|ref|NP_491828.3| kex-2 Proprotein Convertase, endopr... 362 1e-98
gi|25289985|pir||F87803 protein bli-4B [imported] - Caenorhabdit... 362 1e-98
gi|48097899|ref|XP_393918.1| similar to subtilisin-related prote... 359 2e-97
gi|7498890|pir||T20759 hypothetical protein F11A6.1b - Caenorhab... 357 6e-97
gi|671686|gb|AAA87177.1| truncated furin endoprotease 347 5e-94
gi|252086|gb|AAB22663.1| type 2 proinsulin processing endopeptid... 344 5e-93
gi|19115747|ref|NP_594835.1| dibasic processing endoprotease pre... 342 2e-92
gi|20336186|ref|NP_612195.1| paired basic amino acid cleaving sy... 336 1e-90
gi|47219925|emb|CAF97195.1| unnamed protein product [Tetraodon n... 331 4e-89
gi|50291205|ref|XP_448035.1| unnamed protein product [Candida gl... 328 2e-88
gi|32420423|ref|XP_330655.1| hypothetical protein [Neurospora cr... 326 1e-87
gi|9506957|ref|NP_062119.1| proprotein convertase subtilisin / k... 324 5e-87
gi|12643731|sp|Q16549|PCK7_HUMAN Proprotein convertase subtilisi... 323 9e-87
gi|20336248|ref|NP_004707.2| proprotein convertase subtilisin/ke... 323 1e-86
gi|30583995|gb|AAP36246.1| Homo sapiens proprotein convertase su... 323 1e-86
gi|29466651|dbj|BAC66791.1| kexin like processing protease [Aspe... 321 5e-86
gi|13879499|gb|AAH06730.1| Proprotein convertase subtilisin/kexi... 319 1e-85
gi|27413306|gb|AAM97495.1| serine endopeptidase KEX1 [Pneumocyst... 319 1e-85
gi|46134033|ref|XP_389332.1| hypothetical protein FG09156.1 [Gib... 319 2e-85
gi|6679231|ref|NP_032820.1| proprotein convertase subtilisin/kex... 318 2e-85
gi|13183375|gb|AAK15173.1| Kex2 proprotein convertase [Candida g... 317 9e-85
gi|49072338|ref|XP_400458.1| hypothetical protein UM02843.1 [Ust... 311 4e-83
gi|125348|sp|P09231|KEX1_KLULA KEX1 protease precursor >gnl|BL_O... 311 5e-83
gi|50307897|ref|XP_453942.1| KEX1_KLULA [Kluyveromyces lactis] >... 311 5e-83
gi|6324091|ref|NP_014161.1| prohormone processing; golgi localiz... 307 7e-82
gi|19698549|gb|AAL93202.1| Kex protein [Paracoccidioides brasili... 306 9e-82
gi|47168726|pdb|1R64|A Chain A, The 2.2 A Crystal Structure Of K... 304 4e-81
gi|33357783|pdb|1OT5|A Chain A, The 2.4 Angstrom Crystal Sructur... 304 4e-81
gi|50761802|ref|XP_424841.1| PREDICTED: similar to Proprotein co... 303 1e-80
gi|1587137|prf||2206277C furin 302 2e-80
gi|50753186|ref|XP_413892.1| PREDICTED: similar to paired basic ... 301 4e-80
gi|6686712|emb|CAB64692.1| kexin precursor [Aspergillus niger] 300 6e-80
gi|49092518|ref|XP_407720.1| hypothetical protein AN3583.2 [Aspe... 296 1e-78
gi|38105760|gb|EAA52147.1| hypothetical protein MG03742.4 [Magna... 293 1e-77
gi|15077280|gb|AAK83111.1| Kex2-like dibasic endoprotease ANPC [... 291 5e-77
gi|45185027|ref|NP_982744.1| ABL203Wp [Eremothecium gossypii] >g... 290 7e-77
gi|33991186|gb|AAH06357.1| PCSK7 protein [Homo sapiens] 289 2e-76
gi|50419215|ref|XP_458130.1| unnamed protein product [Debaryomyc... 287 6e-76
gi|50555908|ref|XP_505362.1| YlXPR6 [Yarrowia lipolytica] >gnl|B... 285 3e-75
gi|28142392|gb|AAO25531.1| Kex2 [Cryptococcus neoformans A/D] 284 6e-75
gi|50255105|gb|EAL17844.1| hypothetical protein CNBL1060 [Crypto... 284 6e-75
gi|47205170|emb|CAF96055.1| unnamed protein product [Tetraodon n... 284 6e-75
gi|14571744|emb|CAC42801.1| probable protease 1 like protein [Pn... 280 7e-74
gi|2327061|gb|AAB66701.1| protease 1 [Pneumocystis carinii f. sp... 280 9e-74
gi|1587136|prf||2206277B pro-hormone-converting enzyme PC1 280 1e-73
gi|6958206|gb|AAF32493.1| kexin-like protease KEX1 [Pneumocystis... 278 3e-73
gi|3334242|sp|O13359|KEX2_CANAL Kexin precursor (KEX2 protease) ... 274 5e-72
gi|46445279|gb|EAL04548.1| hypothetical protein CaO19.12219 [Can... 273 8e-72
gi|5532444|gb|AAD44729.1| furin1 [Lymnaea stagnalis] 273 8e-72
gi|2327063|gb|AAB66702.1| protease 1 [Pneumocystis carinii f. sp... 271 3e-71
gi|14571747|emb|CAC42804.1| possible protease I [Pneumocystis ca... 271 5e-71
gi|4099086|gb|AAD00541.1| KEXIN [Pneumocystis carinii] 270 9e-71
gi|4097495|gb|AAD00101.1| kexin [Pneumocystis carinii] 266 1e-69
gi|14599404|emb|CAC43457.1| protease 1 [Pneumocystis carinii] 264 5e-69
gi|50760142|ref|XP_417906.1| PREDICTED: similar to proprotein co... 262 2e-68
gi|50761382|ref|XP_424712.1| PREDICTED: similar to proprotein co... 262 2e-68
gi|2104566|dbj|BAA19973.1| subtilisin-like protease 3 [Pneumocys... 256 1e-66
gi|17505240|ref|NP_493594.1| aboc, EXpulsion defective AEX-5, Ke... 234 7e-60
gi|3892585|emb|CAA27860.1| furin [Homo sapiens] 232 2e-59
gi|39584396|emb|CAE72534.1| Hypothetical protein CBG19714 [Caeno... 231 6e-59
gi|554180|gb|AAA39375.1| Kex2 homologue 226 2e-57
gi|31482|emb|CAA33745.1| furin [Homo sapiens] 223 1e-56
gi|47224886|emb|CAG06456.1| unnamed protein product [Tetraodon n... 220 8e-56
gi|7500304|pir||T21624 hypothetical protein F32A7.6 - Caenorhabd... 207 6e-52
gi|423565|pir||S34583 serine proteinase (EC 3.4.21.-) PC6B - mou... 207 7e-52
gi|47226415|emb|CAG08431.1| unnamed protein product [Tetraodon n... 206 2e-51
gi|1916024|gb|AAB51126.1| subtilisin-like serine protease LPC [M... 205 3e-51
gi|17227860|ref|NP_484408.1| similar to prohormone convertase [N... 195 4e-48
gi|7511558|pir||T37314 probable kexin (EC 3.4.21.61) - Caenorhab... 177 6e-43
gi|3420261|gb|AAC31891.1| prohormone convertase 2 precursor [Ovi... 173 2e-41
gi|42521990|ref|NP_967370.1| putative extracellular serine prote... 169 2e-40
gi|26335877|dbj|BAC31639.1| unnamed protein product [Mus musculus] 149 3e-34
gi|37524644|ref|NP_927988.1| hypothetical protein [Photorhabdus ... 147 7e-34
gi|23105956|ref|ZP_00092410.1| COG1404: Subtilisin-like serine p... 144 6e-33
gi|2104564|dbj|BAA19972.1| subtilisin-like protease [Pneumocysti... 143 2e-32
gi|34498172|ref|NP_902387.1| probable extracellular serine prote... 140 1e-31
gi|30983810|gb|AAP41213.1| PC1 [Haliotis rubra] 133 1e-29
gi|26991602|ref|NP_747027.1| serine protease, subtilase family [... 132 2e-29
gi|5726672|gb|AAD48508.1| prohormone convertase 2-like protein [... 126 2e-27
gi|28900926|ref|NP_800581.1| putative extracellular serine prote... 126 2e-27
gi|17232362|ref|NP_488910.1| subtilase family peptidase [Nostoc ... 123 2e-26
gi|47218553|emb|CAF98085.1| unnamed protein product [Tetraodon n... 121 7e-26
gi|45508203|ref|ZP_00160543.1| COG1404: Subtilisin-like serine p... 119 3e-25
gi|47209758|emb|CAF89950.1| unnamed protein product [Tetraodon n... 110 1e-22
gi|6706186|emb|CAB65906.1| proprotein convertase PC7 [Gallus gal... 108 4e-22
gi|4868143|gb|AAD31182.1| extracellular serine protease [Aeromon... 108 5e-22
gi|23129836|ref|ZP_00111659.1| COG4935: Regulatory P domain of t... 108 6e-22
gi|3420265|gb|AAC31893.1| prohormone convertase 1 precursor [Ovi... 108 6e-22
gi|7595970|gb|AAF64521.1| extracellular serine protease [Aeromon... 108 6e-22
gi|6706184|emb|CAB65905.1| proprotein convertase PC6 [Gallus gal... 105 3e-21
gi|38456172|gb|AAR21046.1| subtilisin-like protease [Pneumocysti... 105 3e-21
gi|38456160|gb|AAR21040.1| subtilisin-like protease [Pneumocysti... 105 4e-21
gi|38456162|gb|AAR21041.1| subtilisin-like protease [Pneumocysti... 105 4e-21
gi|38456148|gb|AAR21034.1| subtilisin-like protease [Pneumocysti... 105 5e-21
gi|17228876|ref|NP_485424.1| trypsin [Nostoc sp. PCC 7120] >gnl|... 104 9e-21
gi|322063|pir||S29552 trypsin (EC 3.4.21.4) - Anabaena sp. (stra... 103 1e-20
gi|20141703|sp|P23916|PRCA_ANAVA Calcium-dependent protease prec... 103 1e-20
gi|38456178|gb|AAR21049.1| subtilisin-like protease [Pneumocysti... 103 2e-20
gi|38456180|gb|AAR21050.1| subtilisin-like protease [Pneumocysti... 103 2e-20
gi|38456192|gb|AAR21056.1| subtilisin-like protease [Pneumocysti... 103 2e-20
gi|37573678|dbj|BAC98834.1| prohormone convertase2 [Gallus gallus] 102 3e-20
gi|38456150|gb|AAR21035.1| subtilisin-like protease [Pneumocysti... 102 3e-20
gi|39272|emb|CAA40274.1| calcium dependent protease [Anabaena va... 102 3e-20
gi|38456134|gb|AAR21027.1| subtilisin-like protease [Pneumocysti... 102 3e-20
gi|38456142|gb|AAR21031.1| subtilisin-like protease [Pneumocysti... 102 4e-20
gi|38456156|gb|AAR21038.1| subtilisin-like protease [Pneumocysti... 100 1e-19
gi|38456176|gb|AAR21048.1| subtilisin-like protease [Pneumocysti... 100 1e-19
gi|38456186|gb|AAR21053.1| subtilisin-like protease [Pneumocysti... 100 1e-19
gi|38456190|gb|AAR21055.1| subtilisin-like protease [Pneumocysti... 100 1e-19
gi|38456164|gb|AAR21042.1| subtilisin-like protease [Pneumocysti... 100 1e-19
gi|38456196|gb|AAR21058.1| subtilisin-like protease [Pneumocysti... 100 1e-19
gi|38456184|gb|AAR21052.1| subtilisin-like protease [Pneumocysti... 100 2e-19
gi|38456182|gb|AAR21051.1| subtilisin-like protease [Pneumocysti... 100 2e-19
gi|38456202|gb|AAR21061.1| subtilisin-like protease [Pneumocysti... 100 2e-19
gi|6651269|gb|AAF22245.1| serine protease Ahe2 [Aeromonas hydrop... 99 3e-19
gi|38456158|gb|AAR21039.1| subtilisin-like protease [Pneumocysti... 99 3e-19
gi|38456168|gb|AAR21044.1| subtilisin-like protease [Pneumocysti... 99 5e-19
gi|38456212|gb|AAR21066.1| subtilisin-like protease [Pneumocysti... 99 5e-19
gi|38456170|gb|AAR21045.1| subtilisin-like protease [Pneumocysti... 98 6e-19
gi|21243560|ref|NP_643142.1| extracellular serine protease [Xant... 98 8e-19
gi|42521677|ref|NP_967057.1| subtilase [Bdellovibrio bacteriovor... 98 8e-19
gi|38456136|gb|AAR21028.1| subtilisin-like protease [Pneumocysti... 98 8e-19
gi|37573676|dbj|BAC98833.1| prohormone convertase1 [Gallus gallus] 97 1e-18
gi|38456138|gb|AAR21029.1| subtilisin-like protease [Pneumocysti... 97 1e-18
gi|24372456|ref|NP_716498.1| serine protease, subtilase family [... 97 2e-18
gi|8953443|emb|CAB96732.1| dJ1094O14.1 (proprotein convertase su... 97 2e-18
gi|38456206|gb|AAR21063.1| subtilisin-like protease [Pneumocysti... 96 2e-18
gi|38456174|gb|AAR21047.1| subtilisin-like protease [Pneumocysti... 96 2e-18
gi|38456146|gb|AAR21033.1| subtilisin-like protease [Pneumocysti... 96 4e-18
gi|38456214|gb|AAR21067.1| subtilisin-like protease [Pneumocysti... 96 4e-18
gi|38456194|gb|AAR21057.1| subtilisin-like protease [Pneumocysti... 96 4e-18
gi|6649857|gb|AAF21601.1| kexin-like serine endoprotease [Pneumo... 95 5e-18
gi|38456208|gb|AAR21064.1| subtilisin-like protease [Pneumocysti... 95 5e-18
gi|6706188|emb|CAB65907.1| proprotein convertase PACE4 [Gallus g... 94 1e-17
gi|38456204|gb|AAR21062.1| subtilisin-like protease [Pneumocysti... 94 1e-17
gi|38456152|gb|AAR21036.1| subtilisin-like protease [Pneumocysti... 94 1e-17
gi|38086846|ref|XP_355911.1| paired basic amino acid cleaving sy... 93 2e-17
gi|5596358|dbj|BAA82598.1| furin [Oryctolagus cuniculus] 92 5e-17
gi|21229165|ref|NP_635087.1| calcium dependent protease [Methano... 92 6e-17
gi|38456154|gb|AAR21037.1| subtilisin-like protease [Pneumocysti... 90 2e-16
gi|38456140|gb|AAR21030.1| subtilisin-like protease [Pneumocysti... 90 2e-16
gi|38456198|gb|AAR21059.1| subtilisin-like protease [Pneumocysti... 90 2e-16
gi|38456166|gb|AAR21043.1| subtilisin-like protease [Pneumocysti... 89 4e-16
gi|38456188|gb|AAR21054.1| subtilisin-like protease [Pneumocysti... 88 7e-16
gi|21232105|ref|NP_638022.1| extracellular serine protease [Xant... 86 4e-15
gi|38456200|gb|AAR21060.1| subtilisin-like protease [Pneumocysti... 85 6e-15
gi|46106927|ref|ZP_00188066.2| COG1404: Subtilisin-like serine p... 84 9e-15
gi|21232097|ref|NP_638014.1| extracellular serine protease [Xant... 84 1e-14
gi|23126000|ref|ZP_00107910.1| COG1404: Subtilisin-like serine p... 82 4e-14
gi|38456210|gb|AAR21065.1| subtilisin-like protease [Pneumocysti... 82 4e-14
gi|48891510|ref|ZP_00325017.1| COG1404: Subtilisin-like serine p... 82 6e-14
gi|38456144|gb|AAR21032.1| subtilisin-like protease [Pneumocysti... 82 6e-14
gi|48891684|ref|ZP_00325167.1| COG1404: Subtilisin-like serine p... 80 1e-13
gi|48895570|ref|ZP_00328554.1| COG1404: Subtilisin-like serine p... 80 1e-13
gi|45524562|ref|ZP_00175839.1| COG1404: Subtilisin-like serine p... 80 2e-13
gi|67628|pir||PRAISB serine proteinase, calcium-dependent (EC 3.... 79 4e-13
gi|17228491|ref|NP_485039.1| protease [Nostoc sp. PCC 7120] >gnl... 78 9e-13
gi|39997173|ref|NP_953124.1| subtilisin [Geobacter sulfurreducen... 76 3e-12
gi|388289|gb|AAA17442.1| acidic protease V5 76 3e-12
gi|388468|gb|AAB27533.1| extracellular acidic protease V5 [Diche... 76 3e-12
gi|1168687|sp|P42779|BPRV_BACNO Extracellular basic protease pre... 76 3e-12
gi|576815|gb|AAA80562.1| serine protease 76 3e-12
gi|1168688|sp|P42780|BPRX_BACNO Extracellular subtilisin-like pr... 75 4e-12
gi|21243558|ref|NP_643140.1| extracellular serine protease [Xant... 74 1e-11
gi|45508510|ref|ZP_00160848.1| COG1572: Uncharacterized conserve... 74 1e-11
gi|5107011|gb|AAD39923.1| subtilisin-like serine protease [Pneum... 74 2e-11
gi|23115091|ref|ZP_00100343.1| COG1404: Subtilisin-like serine p... 73 2e-11
gi|17229107|ref|NP_485655.1| Subtilase family protein [Nostoc sp... 73 2e-11
gi|2126440|pir||JC4576 serine proteinase V2 (EC 3.4.21.-) precur... 73 2e-11
gi|4106884|gb|AAD03060.1| furin-like protease [Helix aspersa] 72 5e-11
gi|13811426|gb|AAK40114.1| subtilisin/kexin-like protease HreP [... 72 6e-11
gi|48846687|ref|ZP_00300947.1| COG1404: Subtilisin-like serine p... 72 6e-11
gi|48846685|ref|ZP_00300945.1| COG1404: Subtilisin-like serine p... 72 6e-11
gi|1890101|gb|AAB49694.1| protease [Bacillus sp. PD498] 71 8e-11
gi|45508100|ref|ZP_00160440.1| COG1404: Subtilisin-like serine p... 71 1e-10
gi|48845233|ref|ZP_00299518.1| COG1404: Subtilisin-like serine p... 70 1e-10
gi|2118104|pir||I39780 subtilisin (EC 3.4.21.62) Sendai precurso... 70 1e-10
gi|23125374|ref|ZP_00107311.1| COG1404: Subtilisin-like serine p... 70 2e-10
gi|123213|sp|P29143|HLY_HAL17 Halolysin precursor (F-II) >gnl|BL... 70 2e-10
gi|23115113|ref|ZP_00100353.1| COG1404: Subtilisin-like serine p... 70 2e-10
gi|42524477|ref|NP_969857.1| protease [Bdellovibrio bacteriovoru... 69 3e-10
gi|16080891|ref|NP_391719.1| extracellular serine protease [Baci... 69 3e-10
gi|16080860|ref|NP_391688.1| extracellular serine protease [Baci... 69 5e-10
gi|42524110|ref|NP_969490.1| protease [Bdellovibrio bacteriovoru... 69 5e-10
gi|13562134|gb|AAK29176.1| thermophilic alkaline protease [Geoba... 68 9e-10
gi|46916683|emb|CAG23448.1| Hypothetical extracellular protease ... 67 1e-09
gi|11135288|sp|Q45670|THES_BACSJ Thermophilic serine proteinase ... 67 2e-09
gi|15011962|gb|AAK77652.1| IspD [Clostridium difficile] 67 2e-09
gi|28144813|emb|CAD62180.1| subtilisin precursor [Bacillus subti... 67 2e-09
gi|5107009|gb|AAD39922.1| subtilisin-like serine protease [Pneum... 67 2e-09
gi|23100304|ref|NP_693771.1| intracellular alkaline serine prote... 67 2e-09
gi|30350926|gb|AAP22653.1| extracellular serine protease [Aeromo... 67 2e-09
gi|48527529|gb|AAT45896.1| prohormone convertase 1 [Phodopus sun... 67 2e-09
gi|20807306|ref|NP_622477.1| Subtilisin-like serine proteases [T... 66 3e-09
gi|14422313|emb|CAC41625.1| nattokinase [Bacillus subtilis] 66 3e-09
gi|37776955|emb|CAE18180.2| subtilisin [Bacillus subtilis] 66 3e-09
gi|49236546|ref|ZP_00330605.1| COG1404: Subtilisin-like serine p... 66 3e-09
gi|47846838|dbj|BAD21126.1| protease [Bacillus sp. 9860] 66 3e-09
gi|28804242|emb|CAC42085.2| alkaline serine protease precursor [... 66 3e-09
gi|39935005|ref|NP_947281.1| possible serine protease/outer memb... 66 3e-09
gi|7435652|pir||S71451 halolysin R4 (EC 3.4.-.-) precursor - Hal... 65 5e-09
gi|37955348|gb|AAP13815.1| minor extracellular protease StmPr2 p... 65 6e-09
gi|29789086|ref|NP_060043.1| proprotein convertase subtilisin/ke... 65 6e-09
gi|48894958|ref|ZP_00328067.1| COG1404: Subtilisin-like serine p... 65 6e-09
gi|47846840|dbj|BAD21127.1| protease [Bacillus sp. NV1] 65 6e-09
gi|1839353|gb|AAB47045.1| subtilisin=thermostable serine proteas... 65 6e-09
gi|1310967|pdb|1SBI| Subtilisin Bpn' 8397 (E.C. 3.4.21.14) Muta... 65 6e-09
gi|67622|pir||SUBSI subtilisin (EC 3.4.21.62) E precursor - Baci... 65 6e-09
gi|135019|sp|P00783|SUBT_BACSA Subtilisin amylosacchariticus pre... 65 6e-09
gi|549004|sp|P35835|SUBN_BACNA Subtilisin NAT precursor >gnl|BL_... 65 6e-09
gi|16078094|ref|NP_388911.1| serine alkaline protease (subtilisi... 65 6e-09
gi|135021|sp|P29142|SUBT_BACST Subtilisin J precursor >gnl|BL_OR... 65 6e-09
gi|230163|pdb|1MEE|A Chain A, Mesentericopeptidase (E.C.3.4.21.1... 65 8e-09
gi|29164927|gb|AAO65246.1| nattokinase precursor [Bacillus subti... 65 8e-09
gi|361357|prf||1408206A subtilisin amylosacchariticus gene 65 8e-09
gi|14701574|dbj|BAB62028.1| elastase precursor [Prevotella inter... 65 8e-09
gi|48844263|ref|ZP_00298585.1| COG1404: Subtilisin-like serine p... 65 8e-09
gi|21241698|ref|NP_641280.1| extracellular protease [Xanthomonas... 65 8e-09
gi|5107013|gb|AAD39924.1| subtilisin-like serine protease [Pneum... 65 8e-09
gi|135017|sp|P07518|SUBT_BACPU Subtilisin (Alkaline mesentericop... 64 1e-08
gi|1310968|pdb|1SBH| Subtilisin Bpn' 8397+1 (E.C. 3.4.21.14) Mu... 64 1e-08
gi|26541494|gb|AAN85481.1| subtilisin-like secreted protease [St... 64 1e-08
gi|80421|pir||A23624 subtilisin (EC 3.4.21.62) BM - Bacillus sp 64 1e-08
gi|47846836|dbj|BAD21125.1| protease [Bacillus sp. KSM-9865] 64 1e-08
gi|230314|pdb|1S01| Subtilisin BPN(Prime) 8350 (E.C.3.4.21.14) ... 64 1e-08
gi|3986320|dbj|BAA35011.1| lytic enzyme L27 [Bacillus subtilis] 64 2e-08
gi|1498320|gb|AAC25926.1| cell wall-associated protease precurso... 64 2e-08
gi|16078141|ref|NP_388958.1| cell wall-associated protein precur... 64 2e-08
gi|49477014|ref|YP_035204.1| probable intracellular serine prote... 64 2e-08
gi|4139636|pdb|1SCJ|A Chain A, Crystal Structure Of Subtilisin-P... 63 2e-08
gi|23115667|ref|ZP_00100621.1| COG1404: Subtilisin-like serine p... 63 2e-08
gi|21244270|ref|NP_643852.1| protease [Xanthomonas axonopodis pv... 63 2e-08
gi|7415642|dbj|BAA93474.1| alkaline serin proteinase [Bacillus p... 63 2e-08
gi|21220313|ref|NP_626092.1| secreted subtilisin-like protease [... 63 2e-08
gi|39937071|ref|NP_949347.1| possible serine protease/outer memb... 63 2e-08
gi|47846834|dbj|BAD21124.1| protease [Bacillus sp. KSM-KP43] 63 3e-08
gi|38373994|gb|AAR19220.1| dehairing protease precursor [Bacillu... 63 3e-08
gi|7542318|gb|AAF63395.1| putative serine protease [Xanthomonas ... 63 3e-08
gi|45525994|ref|ZP_00177209.1| COG1404: Subtilisin-like serine p... 63 3e-08
gi|30020448|ref|NP_832079.1| Thermitase [Bacillus cereus ATCC 14... 63 3e-08
gi|15791315|ref|NP_281139.1| halolysin; Hly [Halobacterium sp. N... 62 4e-08
gi|46093526|dbj|BAD11988.2| SA protease [Bacillus sp. KSM-LD1] 62 4e-08
gi|42781473|ref|NP_978720.1| alkaline serine protease, subtilase... 62 4e-08
gi|1421200|pdb|2SBT| Subtilisin Novo (E.C.3.4.21.14) 62 4e-08
gi|230319|pdb|1SBT| Subtilisin BPN (E.C.3.4.21.14) 62 4e-08
gi|37521123|ref|NP_924500.1| probable serine proteinase [Gloeoba... 62 5e-08
gi|48527541|gb|AAT45900.1| pro-subtilisin DJ-4 [Bacillus sp. DJ-4] 62 5e-08
gi|46117636|ref|ZP_00174087.2| COG1404: Subtilisin-like serine p... 62 5e-08
gi|5726590|gb|AAD48483.1| alkaline protease A [Bacillus thuringi... 62 5e-08
gi|38524397|dbj|BAD02409.1| protease [Bacillus sp. KSM-LD1] 62 5e-08
gi|23097691|ref|NP_691157.1| microbial serine proteinase [Oceano... 62 5e-08
gi|2118110|pir||I39866 microbial serine proteinase (EC 3.4.21.-)... 62 7e-08
gi|42659601|ref|XP_113228.3| similar to Proprotein convertase su... 62 7e-08
gi|47565736|ref|ZP_00236776.1| alkaline protease A [Bacillus cer... 62 7e-08
gi|29345622|ref|NP_809125.1| protease [Bacteroides thetaiotaomic... 61 9e-08
gi|3719429|gb|AAC63365.1| subtilisin [Bacillus subtilis] 61 9e-08
gi|21230328|ref|NP_636245.1| extracellular protease [Xanthomonas... 61 1e-07
gi|46323356|ref|ZP_00223721.1| COG1404: Subtilisin-like serine p... 61 1e-07
gi|21400250|ref|NP_656235.1| Peptidase_S8, Subtilase family [Bac... 61 1e-07
gi|23100053|ref|NP_693519.1| thermophilic serine proteinase [Oce... 61 1e-07
gi|15613394|ref|NP_241697.1| minor extracellular serine protease... 61 1e-07
gi|16078384|ref|NP_389202.1| intracellular serine protease [Baci... 60 1e-07
gi|5881959|gb|AAD55137.1| lymphoma pro-protein convertase [Homo ... 60 1e-07
gi|29832994|ref|NP_827628.1| putative protease [Streptomyces ave... 60 1e-07
gi|847662|gb|AAA67893.1| subtilisin-like protease [Streptomyces ... 60 1e-07
gi|7435650|pir||JW0075 cysteine-dependent serine proteinase (EC ... 60 1e-07
gi|50761834|ref|XP_429166.1| PREDICTED: similar to proprotein co... 60 2e-07
gi|21241699|ref|NP_641281.1| extracellular protease [Xanthomonas... 60 2e-07
gi|48891817|ref|ZP_00325266.1| COG1404: Subtilisin-like serine p... 59 3e-07
gi|482559|pir||A48373 high-alkaline serine proteinase (EC 3.4.21... 59 3e-07
gi|21230134|ref|NP_636051.1| protease [Xanthomonas campestris pv... 59 3e-07
gi|6137335|pdb|1C9M|A Chain A, Bacillus Lentus Subtilsin (Ser 87... 59 3e-07
gi|14486388|gb|AAK61552.1| fervidolysin [Fervidobacterium penniv... 59 4e-07
gi|6119851|gb|AAF04257.1| subtilisin-like serine protease [Neosp... 59 4e-07
gi|6573500|pdb|1DBI|A Chain A, Crystal Structure Of A Thermostab... 59 4e-07
gi|773560|emb|CAA24990.1| precursor subtilisin [Bacillus amyloli... 59 6e-07
gi|1225905|dbj|BAA05540.1| prepro AprM [Bacillus sp.] 59 6e-07
gi|15613418|ref|NP_241721.1| extracellular alkaline serine prote... 59 6e-07
gi|9626868|ref|NP_041138.1| serine protease [Ictalurid herpesvir... 59 6e-07
gi|135015|sp|P00782|SUBT_BACAM Subtilisin BPN' precursor (Subtil... 59 6e-07
gi|49524070|emb|CAG38357.1| subtilisin-like protease [Phanerocha... 59 6e-07
gi|135016|sp|P00780|SUBT_BACLI Subtilisin Carlsberg precursor >g... 59 6e-07
gi|230336|pdb|1ST2| Subtilisin BPN' (BASox) - Peroxide Inactiva... 59 6e-07
gi|230743|pdb|2SNI|E Chain E, Subtilisin Novo (E.C.3.4.21.14) Co... 59 6e-07
gi|2780869|pdb|1AU9| Subtilisin Bpn' Mutant 8324 In Citrate >gn... 59 6e-07
gi|119308|sp|P27693|ELYA_BACAO Alkaline protease precursor >gnl|... 59 6e-07
gi|3114348|pdb|1AH2| Serine Protease Pb92 From Bacillus Alcalop... 59 6e-07
gi|23200376|pdb|1LW6|E Chain E, Crystal Structure Of The Complex... 59 6e-07
gi|39654622|pdb|1Q5P|A Chain A, S156eS166D VARIANT OF BACILLUS L... 59 6e-07
gi|23115883|ref|ZP_00100731.1| COG1404: Subtilisin-like serine p... 58 7e-07
gi|1094073|prf||2105288A alkaline protease 58 7e-07
gi|494622|pdb|1SUD| Subtilisin Bpn' Crb-S3 (E.C.3.4.21.62) Muta... 58 7e-07
gi|230315|pdb|1S02| Effects Of Engineered Salt Bridges On The S... 58 7e-07
gi|1169513|sp|P41362|ELYA_BACCS Alkaline protease precursor >gnl... 58 7e-07
gi|2624593|pdb|1AK9| Subtilisin Mutant 8321 58 7e-07
gi|730412|sp|Q99405|PRTM_BACSK M-protease >gnl|BL_ORD_ID|1900511... 58 7e-07
gi|267048|sp|P29600|SUBS_BACLE Subtilisin Savinase (Alkaline pro... 58 7e-07
gi|28144815|emb|CAD62181.1| cell wall-associated protease precur... 58 7e-07
gi|14587813|dbj|BAB61726.1| extracellular alkaline serine protea... 58 9e-07
gi|9837236|gb|AAG00492.1| KerA [Bacillus licheniformis] 58 9e-07
gi|494620|pdb|1SUB| Subtilisin Bpn' Crb-S3 (E.C.3.4.21.62) Muta... 58 9e-07
gi|6137334|pdb|1C9J|A Chain A, Bacillus Lentus Subtilisin K27rN8... 58 9e-07
gi|6648584|gb|AAF21237.1| kexin [Pneumocystis carinii] 58 9e-07
gi|32399061|emb|CAD98301.1| subtilisin-like serine protease, pro... 57 1e-06
gi|1066056|gb|AAC43580.1| SprC 57 1e-06
gi|11265391|pir||T43487 hypothetical protein DKFZp434B217.1 - hu... 57 1e-06
gi|2329843|dbj|BAA21780.1| PC2-like prohormone processing enzyme... 57 1e-06
gi|5751154|dbj|BAA02443.2| prepro-thermostable alkaline protease... 57 2e-06
gi|14278487|pdb|1IAV|A Chain A, Structure On Native (Asn 87) Sub... 57 2e-06
gi|5542495|pdb|1UBN|A Chain A, Selenosubtilisin Bpn 57 2e-06
gi|47168367|pdb|1NDU|A Chain A, Bacillus Lentus Subtilisin Varia... 57 2e-06
gi|2118107|pir||JC4802 alkaline proteinase (EC 3.4.21.-) precurs... 57 2e-06
gi|46113939|ref|ZP_00184034.2| COG1404: Subtilisin-like serine p... 57 2e-06
gi|10957460|ref|NP_051605.1| serine protease, subtilase family [... 57 2e-06
gi|995623|emb|CAA62667.1| substilisin Carlsberg [Bacillus lichen... 57 2e-06
gi|995625|emb|CAA62668.1| substilisin Carlsberg [Bacillus lichen... 57 2e-06
gi|16332024|ref|NP_442752.1| serine proteinase [Synechocystis sp... 56 3e-06
gi|21244272|ref|NP_643854.1| serine protease [Xanthomonas axonop... 56 3e-06
gi|3212271|pdb|1A2Q| Subtilisin Bpn' Mutant 7186 56 3e-06
gi|6137336|pdb|1C9N|A Chain A, Bacillus Lentus Substilisin Varia... 56 3e-06
gi|15606951|ref|NP_214333.1| serine protease [Aquifex aeolicus V... 56 3e-06
gi|48856933|ref|ZP_00311090.1| COG1404: Subtilisin-like serine p... 56 3e-06
gi|6648582|gb|AAF21236.1| kexin [Pneumocystis carinii f. sp. car... 56 3e-06
gi|998944|gb|AAB33888.1| intracellular serine proteinase, ISP [B... 56 4e-06
gi|494645|pdb|1THM| Thermitase (E.C.3.4.21.66) 56 4e-06
gi|46314607|ref|ZP_00215192.1| COG1404: Subtilisin-like serine p... 56 4e-06
gi|15807944|ref|NP_285606.1| serine protease, subtilase family [... 56 4e-06
gi|9837238|gb|AAG00493.1| KerA [Bacillus licheniformis] 56 4e-06
gi|267046|sp|P29599|SUBB_BACLE Subtilisin BL (Alkaline protease) 56 4e-06
gi|494617|pdb|1ST3| Subtilisin Bl (E.C.3.4.21.62) 56 4e-06
gi|5821945|pdb|1C3L|A Chain A, Subtilisin-Carlsberg Complexed Wi... 56 4e-06
gi|29832993|ref|NP_827627.1| putative protease [Streptomyces ave... 55 5e-06
gi|21220910|ref|NP_626689.1| putative secreted peptidase [Strept... 55 5e-06
gi|46113940|ref|ZP_00200950.1| COG1404: Subtilisin-like serine p... 55 5e-06
gi|9837240|gb|AAG00494.1| KerA [Bacillus licheniformis] 55 5e-06
gi|46277126|gb|AAS86761.1| keratinase [Bacillus licheniformis] 55 5e-06
gi|50363121|gb|AAT75303.1| keratinase [Bacillus mojavensis] 55 5e-06
gi|11127682|gb|AAG31027.1| subtilisin precursor [Bacillus lichen... 55 5e-06
gi|11127680|gb|AAG31026.1| subtilisin precursor [Bacillus lichen... 55 5e-06
gi|11127684|gb|AAG31028.1| subtilisin precursor [Bacillus lichen... 55 5e-06
gi|640400|pdb|1SCN|E Chain E, Subtilisin Carlsberg (E.C.3.4.21.6... 55 5e-06
gi|229772|pdb|1CSE|E Chain E, Subtilisin Carlsberg (E.C.3.4.21.6... 55 5e-06
gi|545060|gb|AAC60459.1| alkaline serine protease II; AprII [Alt... 55 6e-06
gi|10047149|dbj|BAB13362.1| pre-pro-AprII [Alteromonas sp. O-7] 55 6e-06
gi|135020|sp|P00781|SUBD_BACLI Subtilisin DY >gnl|BL_ORD_ID|8173... 55 6e-06
gi|15614493|ref|NP_242796.1| intracellular alkaline serine prote... 55 8e-06
gi|30249543|ref|NP_841613.1| Serine proteases, subtilase family ... 55 8e-06
gi|119309|sp|P20724|ELYA_BACYA Alkaline elastase YaB precursor >... 55 8e-06
>gi|25146341|ref|NP_505614.2| EGg Laying defective EGL-3, Kex-2
Proprotein Convertase (72.0 kD) (egl-3) [Caenorhabditis
elegans]
gi|7497803|pir||T20131 proprotein convertase 2 (EC 3.4.21.94)
precursor [similarity] - Caenorhabditis elegans
gi|451657|gb|AAA56868.1| prohormone convertase 2 [Caenorhabditis
elegans]
gi|3875147|emb|CAB01635.1| Hypothetical protein C51E3.7a
[Caenorhabditis elegans]
Length = 652
Score = 1329 bits (3440), Expect = 0.0
Identities = 640/652 (98%), Positives = 640/652 (98%)
Frame = -1
Query: 1959 MKNTHVDLICVFLSIFIGIGEAVDVYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVAA 1780
MKNTHVDLICVFLSIFIGIGEAVDVYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVAA
Sbjct: 1 MKNTHVDLICVFLSIFIGIGEAVDVYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVAA 60
Query: 1779 SDNEYHFVQPALVHARTRRSAGHHAKLHNDDEVLHVEQLKGYTRTKRGYRPLEQRLESQF 1600
SDNEYHFVQPALVHARTRRSAGHHAKLHNDDEVLHVEQLKGYTRTKRGYRPLEQRLESQF
Sbjct: 61 SDNEYHFVQPALVHARTRRSAGHHAKLHNDDEVLHVEQLKGYTRTKRGYRPLEQRLESQF 120
Query: 1599 DFSAVMSPSDPLYGYQWYLKNTGQAGGKARLDLNVERAWAMGFTGKNITTAIMDDGVDYM 1420
DFSAVMSPSDPLYGYQWYLKNTGQAGGKARLDLNVERAWAMGFTGKNITTAIMDDGVDYM
Sbjct: 121 DFSAVMSPSDPLYGYQWYLKNTGQAGGKARLDLNVERAWAMGFTGKNITTAIMDDGVDYM 180
Query: 1419 HPDIKNNFNAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDG 1240
HPDIKNNFNAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDG
Sbjct: 181 HPDIKNNFNAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDG 240
Query: 1239 KVAGIRMLDQPYMTDLIEANSMGHEPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGV 1060
KVAGIRMLDQPYMTDLIEANSMGHEPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGV
Sbjct: 241 KVAGIRMLDQPYMTDLIEANSMGHEPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGV 300
Query: 1059 NEGRNGLGSIFVWASXXXXXXXXXXXXGYAASMWTISINSAINNGENAHYDESCSSTLAS 880
NEGRNGLGSIFVWAS GYAASMWTISINSAINNGENAHYDESCSSTLAS
Sbjct: 301 NEGRNGLGSIFVWASGDGGEDDDCNCDGYAASMWTISINSAINNGENAHYDESCSSTLAS 360
Query: 879 TFSNGGRNPETGVATTDLYGRCTRSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTV 700
TFSNGGRNPETGVATTDLYGRCTRSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTV
Sbjct: 361 TFSNGGRNPETGVATTDLYGRCTRSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTV 420
Query: 699 LTSSRNSLFDGRCRDFPSLGINDNHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEM 520
LTSSRNSLFDGRCRDFPSLGINDNHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEM
Sbjct: 421 LTSSRNSLFDGRCRDFPSLGINDNHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEM 480
Query: 519 VMLAMAWKTSPPRYHCTAGLIDTPHEIPADGNLILEINTDGCAGSQFEVRYLEHVQAVVS 340
VMLAMAWKTSPPRYHCTAGLIDTPHEIPADGNLILEINTDGCAGSQFEVRYLEHVQAVVS
Sbjct: 481 VMLAMAWKTSPPRYHCTAGLIDTPHEIPADGNLILEINTDGCAGSQFEVRYLEHVQAVVS 540
Query: 339 FNSTRRGDTTLYLISPMGTRTMILSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVA 160
FNSTRRGDTTLYLISPMGTRTMILSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVA
Sbjct: 541 FNSTRRGDTTLYLISPMGTRTMILSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVA 600
Query: 159 RFQGPGAHAGTLKKFELMLHGTREAPYNLIEPIVGQTNKKLDTVQKAHKRSH 4
RFQGPGAHAGTLKKFELMLHGTREAPYNLIEPIVGQTNKKLDTVQKAHKRSH
Sbjct: 601 RFQGPGAHAGTLKKFELMLHGTREAPYNLIEPIVGQTNKKLDTVQKAHKRSH 652
>gi|14537990|gb|AAK66762.1| proprotein convertase 2 [Heterodera
glycines]
Length = 671
Score = 1008 bits (2607), Expect = 0.0
Identities = 485/639 (75%), Positives = 536/639 (82%), Gaps = 10/639 (1%)
Frame = -1
Query: 1896 AVDVYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVAASDNEYHFVQPALVHARTRRSA 1717
A++V+TNHF VH G E+AHR+AKR+GF+NRG V SD ++HFVQPAL HARTRRS
Sbjct: 30 ALEVFTNHFLVHTNTAG-TENAHRVAKRNGFVNRGPVLGSDTQWHFVQPALSHARTRRSV 88
Query: 1716 GHHAKLHNDDEVLHVEQLKGYTRTKRGYRPLEQRLESQFDFSAVMSPSDPLYGYQWYLKN 1537
GH+AKL D ++ +VEQ+ GY R KRGYRPL RL+ Q DF++V SP+DPLY +QWYLKN
Sbjct: 89 GHNAKLSQDKDIAYVEQMTGYKRLKRGYRPLADRLQKQLDFTSVQSPTDPLYPFQWYLKN 148
Query: 1536 TGQAGGKARLDLNVERAWAMGFTGKNITTAIMDDGVDYMHPDIKNNFNAEASYDFSSNDP 1357
GQ+ GK RLDLNVE+AWA+G+TGKNITTAIMDDGVDYMH D++ NFNAEASYDFSSNDP
Sbjct: 149 DGQSNGKPRLDLNVEKAWALGYTGKNITTAIMDDGVDYMHADLRFNFNAEASYDFSSNDP 208
Query: 1356 FPYPRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRMLDQPYMTDLIEANS 1177
+PYPRYTDDWFNSHGTRCAGEI AARDNG+CGVGVAYD KVAGIRMLDQPYMTDLIEANS
Sbjct: 209 YPYPRYTDDWFNSHGTRCAGEISAARDNGICGVGVAYDSKVAGIRMLDQPYMTDLIEANS 268
Query: 1176 MGHEPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRNGLGSIFVWASXXXXXX 997
MGHEP+KIHIYSASWGPTDDGKTVDGPRNATMRAIV+GVNEGR GLGSIFVWAS
Sbjct: 269 MGHEPNKIHIYSASWGPTDDGKTVDGPRNATMRAIVKGVNEGRFGLGSIFVWASGDGGED 328
Query: 996 XXXXXXGYAASMWTISINSAINNGENAHYDESCSSTLASTFSNGGRNPETGVATTDLYGR 817
GYAASMWTISINSAINNGENAHYDESCSSTLASTFSNGGRNPE+GVATTDLYGR
Sbjct: 329 DDCNCDGYAASMWTISINSAINNGENAHYDESCSSTLASTFSNGGRNPESGVATTDLYGR 388
Query: 816 CTRSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLTSSRNSLFDGRCRDFPSLGI 637
CTRSHSGTSAAAPEAAGVFAL LEANP LTWRDLQHLTVLTSSRNSLFDGRCR+ P L +
Sbjct: 389 CTRSHSGTSAAAPEAAGVFALTLEANPKLTWRDLQHLTVLTSSRNSLFDGRCRELPPLEL 448
Query: 636 NDNHR---DSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLAMAWKTSPPRYHCTA 466
D R +CSHFEWQ NGVGLEYNHLFGFGVLDAAEMV++A +KT+PPR+HC A
Sbjct: 449 EDIKRQLVSRQASCSHFEWQTNGVGLEYNHLFGFGVLDAAEMVLMAKVYKTAPPRFHCEA 508
Query: 465 GLIDTPHEIPADGNLILEINTDGCAGSQFEVRYLEHVQAVVSFNSTRRGDTTLYLISPMG 286
G I+ P EIPA G ++L + TD C GS EV +LEHVQA+VS NS+RRGDTTLYLISP G
Sbjct: 509 GTIEMPREIPASGEMVLTLRTDACTGSTTEVNFLEHVQAIVSLNSSRRGDTTLYLISPAG 568
Query: 285 TRTMILSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARFQGPG-------AHAGT 127
T +MILSRRPKDDD+KDGFTNWPFMTTHTWGENP G+WRLV RFQ PG + GT
Sbjct: 569 TPSMILSRRPKDDDAKDGFTNWPFMTTHTWGENPRGRWRLVVRFQ-PGKSTPKGHKYRGT 627
Query: 126 LKKFELMLHGTREAPYNLIEPIVGQTNKKLDTVQKAHKR 10
LKKF LMLHGT+E PY IEP+ G N KL VQ AHKR
Sbjct: 628 LKKFTLMLHGTKEPPYRGIEPLQGHANSKLSVVQSAHKR 666
>gi|25289986|pir||C89181 protein C51E3.7b [imported] - Caenorhabditis
elegans
gi|3875154|emb|CAB01642.1| Hypothetical protein C51E3.7b
[Caenorhabditis elegans]
Length = 556
Score = 939 bits (2428), Expect = 0.0
Identities = 452/464 (97%), Positives = 452/464 (97%)
Frame = -1
Query: 1395 NAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRML 1216
NAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRML
Sbjct: 93 NAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRML 152
Query: 1215 DQPYMTDLIEANSMGHEPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRNGLG 1036
DQPYMTDLIEANSMGHEPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRNGLG
Sbjct: 153 DQPYMTDLIEANSMGHEPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRNGLG 212
Query: 1035 SIFVWASXXXXXXXXXXXXGYAASMWTISINSAINNGENAHYDESCSSTLASTFSNGGRN 856
SIFVWAS GYAASMWTISINSAINNGENAHYDESCSSTLASTFSNGGRN
Sbjct: 213 SIFVWASGDGGEDDDCNCDGYAASMWTISINSAINNGENAHYDESCSSTLASTFSNGGRN 272
Query: 855 PETGVATTDLYGRCTRSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLTSSRNSL 676
PETGVATTDLYGRCTRSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLTSSRNSL
Sbjct: 273 PETGVATTDLYGRCTRSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLTSSRNSL 332
Query: 675 FDGRCRDFPSLGINDNHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLAMAWK 496
FDGRCRDFPSLGINDNHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLAMAWK
Sbjct: 333 FDGRCRDFPSLGINDNHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLAMAWK 392
Query: 495 TSPPRYHCTAGLIDTPHEIPADGNLILEINTDGCAGSQFEVRYLEHVQAVVSFNSTRRGD 316
TSPPRYHCTAGLIDTPHEIPADGNLILEINTDGCAGSQFEVRYLEHVQAVVSFNSTRRGD
Sbjct: 393 TSPPRYHCTAGLIDTPHEIPADGNLILEINTDGCAGSQFEVRYLEHVQAVVSFNSTRRGD 452
Query: 315 TTLYLISPMGTRTMILSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARFQGPGAH 136
TTLYLISPMGTRTMILSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARFQGPGAH
Sbjct: 453 TTLYLISPMGTRTMILSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARFQGPGAH 512
Query: 135 AGTLKKFELMLHGTREAPYNLIEPIVGQTNKKLDTVQKAHKRSH 4
AGTLKKFELMLHGTREAPYNLIEPIVGQTNKKLDTVQKAHKRSH
Sbjct: 513 AGTLKKFELMLHGTREAPYNLIEPIVGQTNKKLDTVQKAHKRSH 556
Score = 195 bits (495), Expect = 4e-48
Identities = 92/92 (100%), Positives = 92/92 (100%)
Frame = -1
Query: 1959 MKNTHVDLICVFLSIFIGIGEAVDVYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVAA 1780
MKNTHVDLICVFLSIFIGIGEAVDVYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVAA
Sbjct: 1 MKNTHVDLICVFLSIFIGIGEAVDVYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVAA 60
Query: 1779 SDNEYHFVQPALVHARTRRSAGHHAKLHNDDE 1684
SDNEYHFVQPALVHARTRRSAGHHAKLHNDDE
Sbjct: 61 SDNEYHFVQPALVHARTRRSAGHHAKLHNDDE 92
>gi|39593278|emb|CAE64748.1| Hypothetical protein CBG09536
[Caenorhabditis briggsae]
Length = 556
Score = 917 bits (2369), Expect = 0.0
Identities = 436/464 (93%), Positives = 446/464 (95%)
Frame = -1
Query: 1395 NAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRML 1216
NAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRML
Sbjct: 93 NAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRML 152
Query: 1215 DQPYMTDLIEANSMGHEPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRNGLG 1036
DQPYMTDLIEANSMGHEP+KIHIYSASWGPTDDGKTVDGPRNATMRAIV+GVNEGRNGLG
Sbjct: 153 DQPYMTDLIEANSMGHEPNKIHIYSASWGPTDDGKTVDGPRNATMRAIVKGVNEGRNGLG 212
Query: 1035 SIFVWASXXXXXXXXXXXXGYAASMWTISINSAINNGENAHYDESCSSTLASTFSNGGRN 856
SIFVWAS GYAASMWTISINSAINNGENAHYDESCSSTLASTFSNGGRN
Sbjct: 213 SIFVWASGDGGEDDDCNCDGYAASMWTISINSAINNGENAHYDESCSSTLASTFSNGGRN 272
Query: 855 PETGVATTDLYGRCTRSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLTSSRNSL 676
PETGVATTDLYGRCTRSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLTSSRNSL
Sbjct: 273 PETGVATTDLYGRCTRSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLTSSRNSL 332
Query: 675 FDGRCRDFPSLGINDNHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLAMAWK 496
FDGRCR+ P+LGI DNHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLAMAWK
Sbjct: 333 FDGRCRELPALGIKDNHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLAMAWK 392
Query: 495 TSPPRYHCTAGLIDTPHEIPADGNLILEINTDGCAGSQFEVRYLEHVQAVVSFNSTRRGD 316
T+PPRYHCTAGLIDTPHEIPADGNL+LEI+TDGC G+Q+EVRYLEHVQAVVSFNSTRRGD
Sbjct: 393 TAPPRYHCTAGLIDTPHEIPADGNLVLEIDTDGCVGTQYEVRYLEHVQAVVSFNSTRRGD 452
Query: 315 TTLYLISPMGTRTMILSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARFQGPGAH 136
TTLYLISPMGTRTMILSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARFQGPG H
Sbjct: 453 TTLYLISPMGTRTMILSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARFQGPGEH 512
Query: 135 AGTLKKFELMLHGTREAPYNLIEPIVGQTNKKLDTVQKAHKRSH 4
GT+KKFELMLHGTREAPYN IEPIVGQTNKKLDTVQKAHKRSH
Sbjct: 513 TGTIKKFELMLHGTREAPYNFIEPIVGQTNKKLDTVQKAHKRSH 556
Score = 189 bits (481), Expect = 2e-46
Identities = 89/92 (96%), Positives = 90/92 (97%)
Frame = -1
Query: 1959 MKNTHVDLICVFLSIFIGIGEAVDVYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVAA 1780
MKNTHVDLICVFLSI IGIGEAVDVYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVA
Sbjct: 1 MKNTHVDLICVFLSIIIGIGEAVDVYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVAG 60
Query: 1779 SDNEYHFVQPALVHARTRRSAGHHAKLHNDDE 1684
SDNE+HFVQPALVHARTRRSAGHHAKLHNDDE
Sbjct: 61 SDNEFHFVQPALVHARTRRSAGHHAKLHNDDE 92
>gi|13506775|gb|AAK28328.1| PC2-like protein [Orconectes limosus]
Length = 634
Score = 840 bits (2169), Expect = 0.0
Identities = 413/626 (65%), Positives = 478/626 (75%), Gaps = 1/626 (0%)
Frame = -1
Query: 1887 VYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVAASDNEYHFVQPALVHARTRRSAGHH 1708
V+TN F V ++ GG + AH +AKR+GF NRG VAAS EYHFV AL HART+RS H
Sbjct: 28 VFTNSFLVKVR--GGDDIAHTVAKRNGFENRGPVAASPGEYHFVHHALAHARTKRSLPHT 85
Query: 1707 AKLHNDDEVLHVEQLKGYTRTKRGYRPLE-QRLESQFDFSAVMSPSDPLYGYQWYLKNTG 1531
+L D V Q G+ R KRGY PL+ + L + P+DP + +QWYLKNTG
Sbjct: 86 RQLKADPHVHWAYQQAGFKRVKRGYNPLKVENLVPLHTIQSHQDPTDPYFRFQWYLKNTG 145
Query: 1530 QAGGKARLDLNVERAWAMGFTGKNITTAIMDDGVDYMHPDIKNNFNAEASYDFSSNDPFP 1351
Q GGK RLDLNVE AWA GFTG+N+TTAIMDDG+DYMHPD++NN+NA AS+DFSSNDPFP
Sbjct: 146 QNGGKPRLDLNVEAAWAQGFTGRNVTTAIMDDGIDYMHPDLRNNYNARASWDFSSNDPFP 205
Query: 1350 YPRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRMLDQPYMTDLIEANSMG 1171
+PRYTDDWFNSHGTRCAGE+ AARDNGVCGVGVAY VAGIRMLDQPYMTDLIEANSMG
Sbjct: 206 FPRYTDDWFNSHGTRCAGEVSAARDNGVCGVGVAYSSLVAGIRMLDQPYMTDLIEANSMG 265
Query: 1170 HEPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRNGLGSIFVWASXXXXXXXX 991
EP+ IHIYSASWGPTDDGKTVDGPRNATM+AIVRGVNEGRNGLG+I+VWAS
Sbjct: 266 REPNLIHIYSASWGPTDDGKTVDGPRNATMKAIVRGVNEGRNGLGNIYVWASGDGGEDDD 325
Query: 990 XXXXGYAASMWTISINSAINNGENAHYDESCSSTLASTFSNGGRNPETGVATTDLYGRCT 811
GYAASMWTISINSAIN+G NAHYDESCSSTLASTFSNG ++P TGVATTDLYG+ T
Sbjct: 326 CNCDGYAASMWTISINSAINDGSNAHYDESCSSTLASTFSNGAKDPSTGVATTDLYGKRT 385
Query: 810 RSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLTSSRNSLFDGRCRDFPSLGIND 631
++HSGTSAAAPEAAGVFALALEANP+LTWRD+QHLTVLTS RNSL+D + R
Sbjct: 386 KTHSGTSAAAPEAAGVFALALEANPNLTWRDIQHLTVLTSKRNSLYDAKRR--------- 436
Query: 630 NHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLAMAWKTSPPRYHCTAGLIDT 451
F W MNGVGLEYNHLFGFGVLDA MV LA W T PPRYHC AG+
Sbjct: 437 -----------FSWHMNGVGLEYNHLFGFGVLDAGAMVALARDWVTVPPRYHCQAGIYRI 485
Query: 450 PHEIPADGNLILEINTDGCAGSQFEVRYLEHVQAVVSFNSTRRGDTTLYLISPMGTRTMI 271
P I + +++LE+ TD CAG+ E+ +LEHVQAV++ N+TRRGDT L+L+SPMGT++MI
Sbjct: 486 PKMIAVNKSVVLEMETDACAGTDTELNFLEHVQAVITLNATRRGDTELFLVSPMGTKSMI 545
Query: 270 LSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARFQGPGAHAGTLKKFELMLHGTR 91
LS+RP DDD + GFT WPFMTTHTW ENP G W+L AR G G +K++ LMLHGTR
Sbjct: 546 LSKRPNDDDGRGGFTKWPFMTTHTWAENPRGTWKLEARINSLGPEEGWIKEWTLMLHGTR 605
Query: 90 EAPYNLIEPIVGQTNKKLDTVQKAHK 13
EAPY+ + V + KL V+KAH+
Sbjct: 606 EAPYDHLP--VKDPHSKLAIVKKAHE 629
>gi|17136192|ref|NP_477318.1| CG6438-PA [Drosophila melanogaster]
gi|7301492|gb|AAF56615.1| CG6438-PA [Drosophila melanogaster]
gi|21428888|gb|AAM50163.1| GH12584p [Drosophila melanogaster]
Length = 654
Score = 816 bits (2107), Expect = 0.0
Identities = 406/633 (64%), Positives = 463/633 (73%), Gaps = 8/633 (1%)
Frame = -1
Query: 1887 VYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVAASD-NEYHFVQPALVHARTRRSAGH 1711
V+T+ F V + G AH +A ++GF N G + +D +EYHF L HAR+RRS H
Sbjct: 39 VFTSSFLVRFRRGVDNSFAHDVADKYGFDNLGPLVGADGHEYHFKHRTLPHARSRRSLTH 98
Query: 1710 HAKLHNDDEVLHVEQLKGYTRTKRGYRPLEQRLES-QFDFSAVMS------PSDPLYGYQ 1552
L + V Q G+ R KRG RP + +FD P+DP + Q
Sbjct: 99 TRALKSHPAVHTAVQQPGFKRVKRGLRPAVPAIHGMKFDLKVGEGNRIDEEPTDPYFPMQ 158
Query: 1551 WYLKNTGQAGGKARLDLNVERAWAMGFTGKNITTAIMDDGVDYMHPDIKNNFNAEASYDF 1372
WYLKNTGQ GGK RLDLNV+ AWA G TGKN+TTAIMDDGVDYMHPD+K N+NAEASYDF
Sbjct: 159 WYLKNTGQNGGKVRLDLNVQAAWAQGITGKNVTTAIMDDGVDYMHPDLKFNYNAEASYDF 218
Query: 1371 SSNDPFPYPRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRMLDQPYMTDL 1192
SSNDPFPYPRYTDDWFNSHGTRCAGE+ AARDNG+CGVGVAYD K+AGIRMLDQPYMTDL
Sbjct: 219 SSNDPFPYPRYTDDWFNSHGTRCAGEVAAARDNGICGVGVAYDSKIAGIRMLDQPYMTDL 278
Query: 1191 IEANSMGHEPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRNGLGSIFVWASX 1012
IEANSMGHEP KIHIYSASWGPTDDGKTVDGPRNATMRAIV+GVNEGRNGLG+I+VWAS
Sbjct: 279 IEANSMGHEPHKIHIYSASWGPTDDGKTVDGPRNATMRAIVQGVNEGRNGLGNIYVWASG 338
Query: 1011 XXXXXXXXXXXGYAASMWTISINSAINNGENAHYDESCSSTLASTFSNGGRNPETGVATT 832
GYAASMWTISINSAIN+G+NAHYDESCSSTLASTFSNG ++P TGVATT
Sbjct: 339 DGGEEDDCNCDGYAASMWTISINSAINDGQNAHYDESCSSTLASTFSNGAKDPNTGVATT 398
Query: 831 DLYGRCTRSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLTSSRNSLFDGRCRDF 652
DLYG+CT +HSGTSAAAPEAAGVFALALEANP LTWRD+QHLTVLTS RNSLFD + R
Sbjct: 399 DLYGKCTTTHSGTSAAAPEAAGVFALALEANPQLTWRDIQHLTVLTSKRNSLFDAKNR-- 456
Query: 651 PSLGINDNHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLAMAWKTSPPRYHC 472
F W MNGVGLE+NHLFGFGVLDA MV L+ W + PPRYHC
Sbjct: 457 ------------------FHWTMNGVGLEFNHLFGFGVLDAGAMVTLSKQWHSVPPRYHC 498
Query: 471 TAGLIDTPHEIPADGNLILEINTDGCAGSQFEVRYLEHVQAVVSFNSTRRGDTTLYLISP 292
AG + P I +L EI TD C G+ EV YLEHVQAV+S N++RRGD L+L SP
Sbjct: 499 EAGELTQPQAIVMGRSLFWEIKTDACKGTDTEVNYLEHVQAVISANASRRGDLELFLTSP 558
Query: 291 MGTRTMILSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARFQGPGAHAGTLKKFE 112
MGT++MILSRR DDD +DGFT WPFMTTH+WGE P G W+L ARF P G L ++
Sbjct: 559 MGTKSMILSRRANDDDHRDGFTKWPFMTTHSWGEYPQGTWKLEARFNSPQTRHGNLLEWS 618
Query: 111 LMLHGTREAPYNLIEPIVGQTNKKLDTVQKAHK 13
L+LHGT+EAPY + P + KL V+KAH+
Sbjct: 619 LVLHGTKEAPYRTLHP--SSPHSKLAIVKKAHE 649
>gi|5732438|gb|AAD49105.1| prohormone and neuropeptide processing
protease [Drosophila melanogaster]
Length = 654
Score = 815 bits (2106), Expect = 0.0
Identities = 406/633 (64%), Positives = 463/633 (73%), Gaps = 8/633 (1%)
Frame = -1
Query: 1887 VYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVAASD-NEYHFVQPALVHARTRRSAGH 1711
V+T+ F V + G AH +A ++GF N G + +D +EYHF L HAR+RRS H
Sbjct: 39 VFTSSFLVRFRRGVDNSFAHDVADKYGFDNLGPLVGADGHEYHFKHRTLPHARSRRSLTH 98
Query: 1710 HAKLHNDDEVLHVEQLKGYTRTKRGYRPLEQRLES-QFDFSAVMS------PSDPLYGYQ 1552
L + V Q G+ R KRG RP + +FD P+DP + Q
Sbjct: 99 TRALKSHPAVHTAVQQPGFKRVKRGLRPAVPAIHGMKFDLKVGEGNRIDEEPTDPYFPMQ 158
Query: 1551 WYLKNTGQAGGKARLDLNVERAWAMGFTGKNITTAIMDDGVDYMHPDIKNNFNAEASYDF 1372
WYLKNTGQ GGK RLDLNV+ AWA G TGKN+TTAIMDDGVDYMHPD+K N+NAEASYDF
Sbjct: 159 WYLKNTGQNGGKVRLDLNVQAAWAQGITGKNVTTAIMDDGVDYMHPDLKFNYNAEASYDF 218
Query: 1371 SSNDPFPYPRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRMLDQPYMTDL 1192
SSNDPFPYPRYTDDWFNSHGTRCAGE+ AARDNG+CGVGVAYD K+AGIRMLDQPYMTDL
Sbjct: 219 SSNDPFPYPRYTDDWFNSHGTRCAGEVAAARDNGICGVGVAYDSKIAGIRMLDQPYMTDL 278
Query: 1191 IEANSMGHEPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRNGLGSIFVWASX 1012
IEANSMGHEP KIHIYSASWGPTDDGKTVDGPRNATMRAIV+GVNEGRNGLG+I+VWAS
Sbjct: 279 IEANSMGHEPHKIHIYSASWGPTDDGKTVDGPRNATMRAIVQGVNEGRNGLGNIYVWASG 338
Query: 1011 XXXXXXXXXXXGYAASMWTISINSAINNGENAHYDESCSSTLASTFSNGGRNPETGVATT 832
GYAASMWTISINSAIN+G+NAHYDESCSSTLASTFSNG ++P TGVATT
Sbjct: 339 DGGEEDDCNCDGYAASMWTISINSAINDGQNAHYDESCSSTLASTFSNGAKDPNTGVATT 398
Query: 831 DLYGRCTRSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLTSSRNSLFDGRCRDF 652
DLYG+CT +HSGTSAAAPEAAGVFALALEANP LTWRD+QHLTVLTS RNSLFD + R
Sbjct: 399 DLYGKCTTTHSGTSAAAPEAAGVFALALEANPQLTWRDIQHLTVLTSKRNSLFDAKNR-- 456
Query: 651 PSLGINDNHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLAMAWKTSPPRYHC 472
F W MNGVGLE+NHLFGFGVLDA MV L+ W + PPRYHC
Sbjct: 457 ------------------FHWTMNGVGLEFNHLFGFGVLDAGAMVTLSKQWHSVPPRYHC 498
Query: 471 TAGLIDTPHEIPADGNLILEINTDGCAGSQFEVRYLEHVQAVVSFNSTRRGDTTLYLISP 292
AG + P I +L EI TD C G+ EV YLEHVQAV+S N++RRGD L+L SP
Sbjct: 499 EAGELTQPQAIVMGRSLFWEIKTDACKGTDTEVNYLEHVQAVISANASRRGDLELFLTSP 558
Query: 291 MGTRTMILSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARFQGPGAHAGTLKKFE 112
MGT++MILSRR DDD +DGFT WPFMTTH+WGE P G W+L ARF P G L ++
Sbjct: 559 MGTQSMILSRRANDDDHRDGFTKWPFMTTHSWGEYPQGTWKLEARFNSPQTRHGNLLEWS 618
Query: 111 LMLHGTREAPYNLIEPIVGQTNKKLDTVQKAHK 13
L+LHGT+EAPY + P + KL V+KAH+
Sbjct: 619 LVLHGTKEAPYRTLHP--SSPHSKLAIVKKAHE 649
>gi|31198129|ref|XP_308012.1| ENSANGP00000019377 [Anopheles gambiae]
gi|21291618|gb|EAA03763.1| ENSANGP00000019377 [Anopheles gambiae str.
PEST]
Length = 665
Score = 815 bits (2105), Expect = 0.0
Identities = 405/630 (64%), Positives = 464/630 (73%), Gaps = 4/630 (0%)
Frame = -1
Query: 1890 DVYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVAASDN-EYHFVQPALVHARTRRSAG 1714
DV+T+ F V K + H IA R+GF N G++ S+ E+HF L RTRRS
Sbjct: 53 DVFTSSFLVRFKRSLDKQLVHEIASRNGFQNLGELPGSNGKEFHFKHTTLPLVRTRRSIS 112
Query: 1713 HHAKLHNDDEVLHVEQLKGYTRTKRGYR---PLEQRLESQFDFSAVMSPSDPLYGYQWYL 1543
H L + V Q G+ R KRG+R PL + + P+DP + +QWYL
Sbjct: 113 HTRVLKKEPLVHTAIQQSGFKRVKRGFRHAVPLNYIPDKAPGYGGENVPTDPYFPFQWYL 172
Query: 1542 KNTGQAGGKARLDLNVERAWAMGFTGKNITTAIMDDGVDYMHPDIKNNFNAEASYDFSSN 1363
KNTGQ GGKA+LDLNV AW G TGKNITTAIMDDGVDYMH D+K N+NAEASYDFSSN
Sbjct: 173 KNTGQNGGKAKLDLNVLAAWDQGITGKNITTAIMDDGVDYMHADLKFNYNAEASYDFSSN 232
Query: 1362 DPFPYPRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRMLDQPYMTDLIEA 1183
DPFPYPRYTDDWFNSHGTRCAGE+ AARDNG+CGVGVAYD K+AGIRMLDQPYMTDLIEA
Sbjct: 233 DPFPYPRYTDDWFNSHGTRCAGEVAAARDNGICGVGVAYDSKIAGIRMLDQPYMTDLIEA 292
Query: 1182 NSMGHEPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRNGLGSIFVWASXXXX 1003
NSMGHEP KIHIYSASWGPTDDGKTVDGPRNATMRAIV+GVNEGRNGLG+I+VWAS
Sbjct: 293 NSMGHEPHKIHIYSASWGPTDDGKTVDGPRNATMRAIVQGVNEGRNGLGNIYVWASGDGG 352
Query: 1002 XXXXXXXXGYAASMWTISINSAINNGENAHYDESCSSTLASTFSNGGRNPETGVATTDLY 823
GYAASMWTISINSAIN+G+NAHYDESCSSTLASTFSNG ++P TGVATTDLY
Sbjct: 353 EEDDCNCDGYAASMWTISINSAINDGQNAHYDESCSSTLASTFSNGAKDPNTGVATTDLY 412
Query: 822 GRCTRSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLTSSRNSLFDGRCRDFPSL 643
G+CT +HSGTSAAAPEAAGVFALALEANP L+WRD+QHLTVLTS RNSLFD + R
Sbjct: 413 GKCTTTHSGTSAAAPEAAGVFALALEANPLLSWRDMQHLTVLTSKRNSLFDAKNR----- 467
Query: 642 GINDNHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLAMAWKTSPPRYHCTAG 463
F W MNGVGLE+NHLFGFGVLDA MV LA W+T PPRYHC AG
Sbjct: 468 ---------------FHWTMNGVGLEFNHLFGFGVLDAGAMVALAKKWRTVPPRYHCEAG 512
Query: 462 LIDTPHEIPADGNLILEINTDGCAGSQFEVRYLEHVQAVVSFNSTRRGDTTLYLISPMGT 283
I H IP+ G+L L I T+ C G+ EVRYLEHVQAV++ N++RRGD L+L SPMGT
Sbjct: 513 AITQMHRIPSSGSLYLPIKTNACKGTDTEVRYLEHVQAVITANASRRGDLELFLTSPMGT 572
Query: 282 RTMILSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARFQGPGAHAGTLKKFELML 103
R+MILS+R DDD +DGFT WPFMTTHTWGE P G W L A F + +G +K+F L+L
Sbjct: 573 RSMILSKRANDDDRRDGFTKWPFMTTHTWGEYPQGTWMLEATFNSQESRSGWIKEFSLVL 632
Query: 102 HGTREAPYNLIEPIVGQTNKKLDTVQKAHK 13
HGT++ PY + P + KL V+KAH+
Sbjct: 633 HGTKDPPYQTLSP--ASPHSKLAIVKKAHE 660
>gi|1620966|emb|CAA70106.1| PC2-like prohormone convertase [Lucilia
cuprina]
gi|1620968|emb|CAA70107.1| PC2-like prohormone convertase [Lucilia
cuprina]
Length = 675
Score = 811 bits (2096), Expect = 0.0
Identities = 407/635 (64%), Positives = 465/635 (73%), Gaps = 9/635 (1%)
Frame = -1
Query: 1890 DVYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQ-VAASDNEYHFVQPALVHARTRRSAG 1714
DV+T+ F V + + AH +A ++GF N G V +EYHF L HAR+RRS
Sbjct: 58 DVFTSSFLVRFRRSVDNDFAHNVANKYGFENLGALVGGQGHEYHFKHRTLPHARSRRSIP 117
Query: 1713 HHAKLHNDDEVLHVEQLKGYTRTKRGYRPLEQ-----RLESQFDFSAVMS---PSDPLYG 1558
H L + + Q G+ R KRG RP + ++ ++ + M P+DP +
Sbjct: 118 HTRLLKSHPMIHTAVQQPGFKRVKRGLRPAVHAIHGLKFDATYNTQSSMESTEPTDPYFP 177
Query: 1557 YQWYLKNTGQAGGKARLDLNVERAWAMGFTGKNITTAIMDDGVDYMHPDIKNNFNAEASY 1378
QWYLKNTGQ GGKARLDLNV+ AW G TGKN+TTAIMDDGVDYMHPD+K N+NAEASY
Sbjct: 178 MQWYLKNTGQNGGKARLDLNVQAAWDQGITGKNVTTAIMDDGVDYMHPDLKFNYNAEASY 237
Query: 1377 DFSSNDPFPYPRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRMLDQPYMT 1198
DFSSNDPFPYPRYTDDWFNSHGTRCAGE+ AARDNG+CGVGVAYD K+AGIRMLDQPYMT
Sbjct: 238 DFSSNDPFPYPRYTDDWFNSHGTRCAGEVAAARDNGICGVGVAYDSKIAGIRMLDQPYMT 297
Query: 1197 DLIEANSMGHEPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRNGLGSIFVWA 1018
DLIEANSMGHEP KIHIYSASWGPTDDGKTVDGPRNATMRAIV+GVNEGRNGLG+I+VWA
Sbjct: 298 DLIEANSMGHEPHKIHIYSASWGPTDDGKTVDGPRNATMRAIVQGVNEGRNGLGNIYVWA 357
Query: 1017 SXXXXXXXXXXXXGYAASMWTISINSAINNGENAHYDESCSSTLASTFSNGGRNPETGVA 838
S GYAASMWTISINSAIN+G+NAHYDESCSSTLASTFSNG ++P TGVA
Sbjct: 358 SGDGGEEDDCNCDGYAASMWTISINSAINDGQNAHYDESCSSTLASTFSNGAKDPNTGVA 417
Query: 837 TTDLYGRCTRSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLTSSRNSLFDGRCR 658
TTDLYG+CT +HSGTSAAAPEAAGVFALALEANP LTWRD+QHLTVLTS RNSLFD + R
Sbjct: 418 TTDLYGKCTTTHSGTSAAAPEAAGVFALALEANPQLTWRDIQHLTVLTSKRNSLFDAKNR 477
Query: 657 DFPSLGINDNHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLAMAWKTSPPRY 478
F W MNGVGLE+NHLFGFGVLDA MV LA W T P RY
Sbjct: 478 --------------------FHWTMNGVGLEFNHLFGFGVLDAGGMVTLAKQWHTVPARY 517
Query: 477 HCTAGLIDTPHEIPADGNLILEINTDGCAGSQFEVRYLEHVQAVVSFNSTRRGDTTLYLI 298
HC AG I H I + +L LEI TD C G+ EV YLEHVQAV+S N++RRGD L+L
Sbjct: 518 HCEAGDIVDAHPIYSGRSLYLEIKTDACKGTDTEVNYLEHVQAVISANASRRGDLELFLT 577
Query: 297 SPMGTRTMILSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARFQGPGAHAGTLKK 118
SPMGTR+MILSRR DDD +DGFT WPFMTTH+WGE P G W+L ARF +G L
Sbjct: 578 SPMGTRSMILSRRTNDDDHRDGFTKWPFMTTHSWGEYPHGTWKLEARFNSNQPRSGWLID 637
Query: 117 FELMLHGTREAPYNLIEPIVGQTNKKLDTVQKAHK 13
+ L+LHGT+EAPY + P + KL V+KAH+
Sbjct: 638 WSLVLHGTKEAPYRTLSP--ASPHSKLAIVKKAHE 670
>gi|48095938|ref|XP_392366.1| similar to PC2-like prohormone
convertase [Apis mellifera]
Length = 1639
Score = 763 bits (1971), Expect = 0.0
Identities = 398/695 (57%), Positives = 461/695 (66%), Gaps = 65/695 (9%)
Frame = -1
Query: 1902 GEAVDVYTNHFHVHLKEGGGLEDAHRIAKRHGFINRG----------------------- 1792
G + +V+TN F V +++ A R+A R+GF+N G
Sbjct: 104 GSSAEVFTNTFLVKMRQPAERHIADRVAARNGFVNLGPRRDKTGMDGMDLNANRRVTDFK 163
Query: 1791 ----------QVAASDNEYHFVQPALVHARTRRSAGHHAKLHNDD---EVLHVE------ 1669
+ S EYHFV AL HAR++RS H +L D ++L E
Sbjct: 164 SQGWNCQNAMNILGSQTEYHFVHKALPHARSKRSVPHMRRLKVDPLDVQLLFAEGDRMSG 223
Query: 1668 -----------------QLKGYTRTKRGYRPLE-QRLESQFDFSAVMSP-----SDPLYG 1558
Q G+ R KRGY+PL L + +P SDP +
Sbjct: 224 LVQERTRLKMFQVHTAVQQPGFKRVKRGYKPLSVDNLVPLYQIKNPSNPGNRDPSDPYFQ 283
Query: 1557 YQWYLKNTGQAGGKARLDLNVERAWAMGFTGKNITTAIMDDGVDYMHPDIKNNFNAEASY 1378
YQWYLKNTGQ GGK +LDLNV+ AWA G TGKN+TTAIMDDG + N +ASY
Sbjct: 284 YQWYLKNTGQNGGKPKLDLNVKAAWAQGVTGKNVTTAIMDDG--------ETPINTKASY 335
Query: 1377 DFSSNDPFPYPRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRMLDQPYMT 1198
DFSSNDP+PYPRYTDDWFNSHGTRCAGE+ AARDNGVCGVGVAYD KVAGIRMLDQPYMT
Sbjct: 336 DFSSNDPYPYPRYTDDWFNSHGTRCAGEVAAARDNGVCGVGVAYDSKVAGIRMLDQPYMT 395
Query: 1197 DLIEANSMGHEPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRNGLGSIFVWA 1018
DLIEANSMGHEP I IYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGR GLG+I+VWA
Sbjct: 396 DLIEANSMGHEPDLIDIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRRGLGNIYVWA 455
Query: 1017 SXXXXXXXXXXXXGYAASMWTISINSAINNGENAHYDESCSSTLASTFSNGGRNPETGVA 838
S GYAASMWT+SINSAIN+G+NAHYDESCSSTLASTFSNG ++P GVA
Sbjct: 456 SGDGGEEDDCNCDGYAASMWTVSINSAINDGQNAHYDESCSSTLASTFSNGAKDPNIGVA 515
Query: 837 TTDLYGRCTRSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLTSSRNSLFDGRCR 658
TTDLYG+CT +HSGTSAAAPEAAGVFALALEANP LTWRD+QHLTVLTS RNSLFD + R
Sbjct: 516 TTDLYGKCTTTHSGTSAAAPEAAGVFALALEANPQLTWRDIQHLTVLTSKRNSLFDAKGR 575
Query: 657 DFPSLGINDNHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLAMAWKTSPPRY 478
F W MNGVGLE+NHLFG+GVLDA MV LA WKT PPRY
Sbjct: 576 --------------------FHWTMNGVGLEFNHLFGYGVLDAGAMVALAKKWKTVPPRY 615
Query: 477 HCTAGLIDTPHEIPADGNLILEINTDGCAGSQFEVRYLEHVQAVVSFNSTRRGDTTLYLI 298
HC AG + E+ +D +++L+I TD CAG+++ V YLEHVQAV+S N+TRRGD L+L
Sbjct: 616 HCEAGSVLETQEVTSDRSILLKIKTDACAGTEYAVNYLEHVQAVISVNATRRGDLELFLT 675
Query: 297 SPMGTRTMILSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARFQGPGAHAGTLKK 118
SPMGTR+MILSRR DDD +DGFT WPFMTTHTWGE P G W L F G +++
Sbjct: 676 SPMGTRSMILSRRINDDDHRDGFTKWPFMTTHTWGEYPQGNWLLEVSFNTQTPQHGWIRE 735
Query: 117 FELMLHGTREAPYNLIEPIVGQTNKKLDTVQKAHK 13
+ LMLHGTRE PY + + KL V+KAH+
Sbjct: 736 WTLMLHGTREPPYTGLP--AADPHSKLAIVKKAHE 768
>gi|280683|pir||S23118 proprotein convertase 2 (EC 3.4.21.94)
precursor [similarity] - African clawed frog
gi|64972|emb|CAA47118.1| convertase PC2 [Xenopus laevis]
Length = 639
Score = 725 bits (1871), Expect = 0.0
Identities = 367/623 (58%), Positives = 440/623 (69%), Gaps = 1/623 (0%)
Frame = -1
Query: 1887 VYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVAASDNEYHFVQPALVHARTRRSAGHH 1708
V T+HF V L+EGG E A ++A +GF ++ S + YHF + +R+RRS
Sbjct: 29 VLTDHFLVDLREGGEAE-AEQLAAEYGFSGTRKLPFSQSLYHFYGNGITTSRSRRSVNKK 87
Query: 1707 AKLHNDDEVLHVEQLKGYTRTKRGYRPLEQRLESQFDFSAVMSPSDPLYGYQWYLKNTGQ 1528
L D +V VEQ +G+ R KRGYR + ++ +DPL+ QWYL NTGQ
Sbjct: 88 KHLAMDPKVNKVEQQEGFHRKKRGYRDIND---------IEINMNDPLFTKQWYLINTGQ 138
Query: 1527 AGGKARLDLNVERAWAMGFTGKNITTAIMDDGVDYMHPDIKNNFNAEASYDFSSNDPFPY 1348
A G LDLNV AW +G+TG+ +T AIMDDG+DY+HPD+ +N+NAEASYDFSSNDP+PY
Sbjct: 139 ADGTPGLDLNVAEAWELGYTGRGVTIAIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPY 198
Query: 1347 PRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRMLDQPYMTDLIEANSMGH 1168
PRYTDDWFNSHGTRCAGE+ A+ +N +CGVGVAY+ KVAGIRMLDQP+MTD+IEA+S+ H
Sbjct: 199 PRYTDDWFNSHGTRCAGEVSASANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISH 258
Query: 1167 EPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRNGLGSIFVWASXXXXXXXXX 988
P I IYSASWGPTDDGKTVDGPR T++A+ GVN+GR G GSI+VWAS
Sbjct: 259 MPQVIDIYSASWGPTDDGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDC 318
Query: 987 XXXGYAASMWTISINSAINNGENAHYDESCSSTLASTFSNG-GRNPETGVATTDLYGRCT 811
GYA+SMWTISINSAIN+G A YDESCSSTLASTFSNG RNPE GVATTDLYG CT
Sbjct: 319 NCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCT 378
Query: 810 RSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLTSSRNSLFDGRCRDFPSLGIND 631
HSGTSAAAPEAAGVFALALEANP LTWRDLQHL+VLTS RN L
Sbjct: 379 LRHSGTSAAAPEAAGVFALALEANPGLTWRDLQHLSVLTSKRNQL--------------- 423
Query: 630 NHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLAMAWKTSPPRYHCTAGLIDT 451
H + H +W+ NGVGLE+NHLFG+GVLDA MV +A WKT P R+HC G I
Sbjct: 424 -HDEVH------KWRRNGVGLEFNHLFGYGVLDAGAMVKMANEWKTVPERFHCIGGAIQE 476
Query: 450 PHEIPADGNLILEINTDGCAGSQFEVRYLEHVQAVVSFNSTRRGDTTLYLISPMGTRTMI 271
P +IP+DG LIL ++TD C G + VRYLEHVQAV++ NSTRRGD + + SPMGT++++
Sbjct: 477 PRKIPSDGKLILTLSTDACEGKENFVRYLEHVQAVITVNSTRRGDLNINMTSPMGTKSIL 536
Query: 270 LSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARFQGPGAHAGTLKKFELMLHGTR 91
LSRRP+DDDSK GF WPFMTTHTWGE+P G W L F G G LK++ LMLHGT+
Sbjct: 537 LSRRPRDDDSKVGFDKWPFMTTHTWGEDPRGTWVLEVGFVGSIPEKGVLKEWTLMLHGTQ 596
Query: 90 EAPYNLIEPIVGQTNKKLDTVQK 22
APY I+ IV KL +K
Sbjct: 597 SAPY--IDQIVRDYQSKLAMSKK 617
>gi|49256229|gb|AAH74270.1| Unknown (protein for MGC:84034) [Xenopus
laevis]
Length = 639
Score = 724 bits (1868), Expect = 0.0
Identities = 370/640 (57%), Positives = 444/640 (68%), Gaps = 1/640 (0%)
Frame = -1
Query: 1938 LICVFLSIFIGIGEAVDVYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVAASDNEYHF 1759
L+ S+ + G V T+HF V L+EGG E A ++A +GF ++ + + YHF
Sbjct: 14 LVLHLASLLVSAGRPV--LTHHFLVDLREGGEAE-AKQLAAEYGFSGTRKLPFTQSSYHF 70
Query: 1758 VQPALVHARTRRSAGHHAKLHNDDEVLHVEQLKGYTRTKRGYRPLEQRLESQFDFSAVMS 1579
+ +R RRS L D +V V Q +G+ R KRGYR + + D +
Sbjct: 71 YGNGITKSRHRRSVNKKKHLAVDPKVNKVVQQEGFHRKKRGYRDI-----NDIDINV--- 122
Query: 1578 PSDPLYGYQWYLKNTGQAGGKARLDLNVERAWAMGFTGKNITTAIMDDGVDYMHPDIKNN 1399
+DPL+ QWYL NTGQA G LDLNV AW +G+TG+ +T AIMDDG+DY+HPD+ +N
Sbjct: 123 -NDPLFTKQWYLVNTGQADGTPGLDLNVAEAWELGYTGRGVTIAIMDDGIDYLHPDLASN 181
Query: 1398 FNAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRM 1219
+NAEASYDFSSNDP+PYPRYTDDWFNSHGTRCAGE+ AA +N +CGVGVAY+ KVAGIRM
Sbjct: 182 YNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRM 241
Query: 1218 LDQPYMTDLIEANSMGHEPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRNGL 1039
LDQP+MTD+IEA+S+ H P I IYSASWGPTDDGKTVDGPR T++A+ GVN+GR G
Sbjct: 242 LDQPFMTDIIEASSISHMPQVIDIYSASWGPTDDGKTVDGPRELTLQAMADGVNKGRGGK 301
Query: 1038 GSIFVWASXXXXXXXXXXXXGYAASMWTISINSAINNGENAHYDESCSSTLASTFSNG-G 862
GSI+VWAS GYA+SMWTISINSAIN+G A YDESCSSTLASTFSNG
Sbjct: 302 GSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRK 361
Query: 861 RNPETGVATTDLYGRCTRSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLTSSRN 682
RNPE GVATTDLYG CT HSGTSAAAPEAAGVFAL LEANP LTWRDLQHLTVLTS RN
Sbjct: 362 RNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALTLEANPGLTWRDLQHLTVLTSKRN 421
Query: 681 SLFDGRCRDFPSLGINDNHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLAMA 502
L H + H +W+ NGVGLE+NHLFG+GVLDA MV +A
Sbjct: 422 KL----------------HDEVH------KWRRNGVGLEFNHLFGYGVLDAGAMVKMAKE 459
Query: 501 WKTSPPRYHCTAGLIDTPHEIPADGNLILEINTDGCAGSQFEVRYLEHVQAVVSFNSTRR 322
WKT P R+HC G I P +IP+DG LIL ++TD C G + VRYLEHVQAV++ NSTRR
Sbjct: 460 WKTVPERFHCIGGAIQEPRKIPSDGKLILTLSTDACEGKENFVRYLEHVQAVITVNSTRR 519
Query: 321 GDTTLYLISPMGTRTMILSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARFQGPG 142
GD + + SPMGT++++LSRRP+DDDSK GF WPFMTTHTWGE+P G W L F G
Sbjct: 520 GDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDPRGTWVLEVGFVGSM 579
Query: 141 AHAGTLKKFELMLHGTREAPYNLIEPIVGQTNKKLDTVQK 22
G LK++ LMLHGT+ APY I+ IV KL +K
Sbjct: 580 PEKGVLKEWTLMLHGTQSAPY--IDQIVRDYQSKLAMSKK 617
>gi|49257870|gb|AAH74387.1| Pcsk2-A protein [Xenopus laevis]
Length = 639
Score = 722 bits (1863), Expect = 0.0
Identities = 366/623 (58%), Positives = 439/623 (69%), Gaps = 1/623 (0%)
Frame = -1
Query: 1887 VYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVAASDNEYHFVQPALVHARTRRSAGHH 1708
V T+HF V L+EGG E A ++A +GF ++ S + YHF + +R+RRS
Sbjct: 29 VLTDHFLVDLREGGEAE-AEQLAAEYGFSGTRKLPFSQSLYHFYGNGITTSRSRRSVNKK 87
Query: 1707 AKLHNDDEVLHVEQLKGYTRTKRGYRPLEQRLESQFDFSAVMSPSDPLYGYQWYLKNTGQ 1528
L D +V VEQ +G+ R KRGYR + ++ +DPL+ QWYL NTGQ
Sbjct: 88 KHLAMDPKVNKVEQQEGFHRKKRGYRDIND---------IEINMNDPLFTKQWYLINTGQ 138
Query: 1527 AGGKARLDLNVERAWAMGFTGKNITTAIMDDGVDYMHPDIKNNFNAEASYDFSSNDPFPY 1348
A G LDLNV AW +G+TG+ +T AIMDDG+DY+HPD+ +N+NAEASYDFSSNDP+PY
Sbjct: 139 ADGTPGLDLNVAEAWELGYTGRGVTIAIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPY 198
Query: 1347 PRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRMLDQPYMTDLIEANSMGH 1168
PRYTDDWFNSHGTRCAGE+ A+ +N +CGVGVAY+ KVAGIRMLDQP+MTD+IEA+S+ H
Sbjct: 199 PRYTDDWFNSHGTRCAGEVSASANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISH 258
Query: 1167 EPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRNGLGSIFVWASXXXXXXXXX 988
P I IYSASWGPTDDGKTVDGPR T++A+ GVN+GR G GSI+VWAS
Sbjct: 259 MPQVIDIYSASWGPTDDGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDC 318
Query: 987 XXXGYAASMWTISINSAINNGENAHYDESCSSTLASTFSNG-GRNPETGVATTDLYGRCT 811
GYA+SMWTISINSAIN+G A YDESCSSTLASTFSNG RNPE GVATTDLYG CT
Sbjct: 319 NCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCT 378
Query: 810 RSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLTSSRNSLFDGRCRDFPSLGIND 631
HSGTSAAAPEAAGVFALALEANP LTWRDLQHL+VLTS RN L
Sbjct: 379 LRHSGTSAAAPEAAGVFALALEANPGLTWRDLQHLSVLTSKRNQL--------------- 423
Query: 630 NHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLAMAWKTSPPRYHCTAGLIDT 451
H + H +W+ NGVGLE+NHLFG+GVLDA MV +A WKT P R+HC G I
Sbjct: 424 -HDEVH------KWRRNGVGLEFNHLFGYGVLDAGAMVKMANEWKTVPERFHCIGGAIQE 476
Query: 450 PHEIPADGNLILEINTDGCAGSQFEVRYLEHVQAVVSFNSTRRGDTTLYLISPMGTRTMI 271
P +I +DG LIL ++TD C G + VRYLEHVQAV++ NSTRRGD + + SPMGT++++
Sbjct: 477 PRKISSDGKLILTLSTDACEGKENFVRYLEHVQAVITVNSTRRGDLNINMTSPMGTKSIL 536
Query: 270 LSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARFQGPGAHAGTLKKFELMLHGTR 91
LSRRP+DDDSK GF WPFMTTHTWGE+P G W L F G G LK++ LMLHGT+
Sbjct: 537 LSRRPRDDDSKVGFDKWPFMTTHTWGEDPRGTWVLEVGFVGSIPEKGVLKEWTLMLHGTQ 596
Query: 90 EAPYNLIEPIVGQTNKKLDTVQK 22
APY I+ IV KL +K
Sbjct: 597 SAPY--IDQIVRDYQSKLAMSKK 617
>gi|542504|pir||S40449 proprotein convertase 2 (EC 3.4.21.94)
precursor [similarity] - California sea hare
gi|430855|gb|AAA03496.1| hormone convertase 2
gi|558493|gb|AAA66497.1| prohormone convertase
Length = 653
Score = 717 bits (1850), Expect = 0.0
Identities = 367/642 (57%), Positives = 443/642 (68%), Gaps = 10/642 (1%)
Frame = -1
Query: 1908 GIGEAVDVYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVAASDNEYHFVQPALVHART 1729
G G +DV TNH+ V L GG E A R+A+ GF G V +SD +HFV + HAR+
Sbjct: 27 GHGRQIDVVTNHWLVELSHDGGPELAKRVARDTGFSYVGPVLSSDRTFHFVHHGVAHARS 86
Query: 1728 RRSAGHHAKLHNDDEVLHVEQLKGYTRTKRGYRPLEQRLESQFDFSAVMS----PSDPLY 1561
RRS H +L V+ Q GY+R KRGY+ ++ L++ A + P+DP +
Sbjct: 87 RRSVPHTRQLRVHPHVVSAFQQNGYSRVKRGYKQTDKLLQANKQSFAYKAKPRLPNDPDF 146
Query: 1560 GYQWYLKNTGQAGGKARLDLNVERAWAMGFTGKNITTAIMDDGVDYMHPDIKNNFNAEAS 1381
G QWYL+NTG++GG LDLNV AW MG++G +TTAIMDDG+DY+H D+K N++A+AS
Sbjct: 147 GKQWYLRNTGESGGVKGLDLNVLEAWEMGYSGAGVTTAIMDDGIDYLHEDLKFNYHADAS 206
Query: 1380 YDFSSNDPFPYPRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRMLDQPYM 1201
YDFSSNDP+PYPRYTD WFNSHGTRCAGE+ AA+DNGVCGVGVA+ KVAG+RMLDQP+M
Sbjct: 207 YDFSSNDPYPYPRYTDTWFNSHGTRCAGEVSAAKDNGVCGVGVAFGSKVAGLRMLDQPFM 266
Query: 1200 TDLIEANSMGHEPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRNGLGSIFVW 1021
TDLIEAN+MGH P+ I IYSASWGPTDDGKTVDGPRN TMRAIV GVN GRNGLG+++VW
Sbjct: 267 TDLIEANAMGHMPNVIDIYSASWGPTDDGKTVDGPRNLTMRAIVNGVNNGRNGLGNVYVW 326
Query: 1020 ASXXXXXXXXXXXXGYAASMWTISINSAINNGENAHYDESCSSTLASTFSNG-GRNPETG 844
AS GYAASMWT+SINSA N+G+ A YDESCSSTLASTFSNG + + G
Sbjct: 327 ASGDGGPNDDCNCDGYAASMWTVSINSATNDGQTAGYDESCSSTLASTFSNGKSSSRDAG 386
Query: 843 VATTDLYGRCTRSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLTSSRNSLFDGR 664
VATTDLY CT SHSGTSAAAPEAAGVFALALEAN +LTWRD+QHLTVLTS RNSL+D
Sbjct: 387 VATTDLYNNCTASHSGTSAAAPEAAGVFALALEANKNLTWRDMQHLTVLTSKRNSLYD-- 444
Query: 663 CRDFPSLGINDNHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLAMAWKTSPP 484
S GI+ W++NG L +NHLFG+GVLDAA MV LA WK P
Sbjct: 445 -----SNGIH-------------HWKLNGAHLLFNHLFGYGVLDAASMVDLARQWKGLPE 486
Query: 483 RYHCTAGLIDTPHEIPADGNLILEINTDGCAGSQFEVRYLEHVQAVVSFNSTRRGDTTLY 304
R+HC AG I + + + I TDGC G++ EV YLEHVQA V+ ST RG T+Y
Sbjct: 487 RFHCKAGSITDKQDFSFGNPVRMSIETDGCVGTENEVNYLEHVQAFVTLRSTYRGCVTMY 546
Query: 303 LISPMGTRTMILSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARFQ-----GPGA 139
L SPMGT +MILS+RP DDD K+GFT WPFMTTHTW E G W L +
Sbjct: 547 LTSPMGTTSMILSQRPNDDDDKNGFTRWPFMTTHTWAELSHGTWSLEIVMEPIIGVKTNM 606
Query: 138 HAGTLKKFELMLHGTREAPYNLIEPIVGQTNKKLDTVQKAHK 13
G K++ L+LHGT+ PY +P +KL V++AH+
Sbjct: 607 ERGVFKEWTLVLHGTKTPPY-ANQPADKDKQEKLYLVRRAHE 647
>gi|37360779|dbj|BAC98351.1| prohormone convertase 2 [Rana
catesbeiana]
Length = 638
Score = 716 bits (1849), Expect = 0.0
Identities = 362/621 (58%), Positives = 433/621 (69%), Gaps = 1/621 (0%)
Frame = -1
Query: 1881 TNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVAASDNEYHFVQPALVHARTRRSAGHHAK 1702
T + V L+ GG DA ++A+++GF ++ SD+ YHF R +RS
Sbjct: 29 TQQYLVDLQPGGEPTDAAQLAQQYGFTGARKLPFSDSLYHFYDSGATKFRRKRSLNSKNH 88
Query: 1701 LHNDDEVLHVEQLKGYTRTKRGYRPLEQRLESQFDFSAVMSPSDPLYGYQWYLKNTGQAG 1522
L +V V Q +G+ R KRGYR + ++ +DPL+ QWYL NTGQA
Sbjct: 89 LSMHPKVRKVVQQEGFDRKKRGYRDIND---------IDINMNDPLFTKQWYLINTGQAD 139
Query: 1521 GKARLDLNVERAWAMGFTGKNITTAIMDDGVDYMHPDIKNNFNAEASYDFSSNDPFPYPR 1342
G LDLNV AW +G+TG+ +T AIMDDG+DY+HPD+ +N+NAEASYDFSSNDP+PYPR
Sbjct: 140 GTPGLDLNVAEAWELGYTGRGVTIAIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPR 199
Query: 1341 YTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRMLDQPYMTDLIEANSMGHEP 1162
YTDDWFNSHGTRCAGE+ AA +N +CGVGVAY+ KVAGIRMLDQP+MTD+IEA+S+ H P
Sbjct: 200 YTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMP 259
Query: 1161 SKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRNGLGSIFVWASXXXXXXXXXXX 982
I IYSASWGPTDDGKTVDGPR T++A+ GVN+GR G GSI+VWAS
Sbjct: 260 QIIDIYSASWGPTDDGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNC 319
Query: 981 XGYAASMWTISINSAINNGENAHYDESCSSTLASTFSNG-GRNPETGVATTDLYGRCTRS 805
GYA+SMWTISINSAIN+G A YDESCSSTLASTFSNG RNPE GVATTDLYG CT
Sbjct: 320 DGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLR 379
Query: 804 HSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLTSSRNSLFDGRCRDFPSLGINDNH 625
HSGTSAAAPEAAGVFALALEANP LTWRDLQHLTVLTS RN L H
Sbjct: 380 HSGTSAAAPEAAGVFALALEANPGLTWRDLQHLTVLTSKRNQL----------------H 423
Query: 624 RDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLAMAWKTSPPRYHCTAGLIDTPH 445
+ H +W+ NGVGLE+NHLFG+GVLDA MV +A WKT P R+HC G I P
Sbjct: 424 DEVH------KWRRNGVGLEFNHLFGYGVLDAGSMVKMAREWKTVPERFHCIGGSIQEPR 477
Query: 444 EIPADGNLILEINTDGCAGSQFEVRYLEHVQAVVSFNSTRRGDTTLYLISPMGTRTMILS 265
+IP+DG L+L + TD C G + VRYLEHVQAV++ NSTRRGD + + SPMGT++++LS
Sbjct: 478 KIPSDGKLMLTLTTDACEGKENFVRYLEHVQAVITVNSTRRGDLNINMTSPMGTKSILLS 537
Query: 264 RRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARFQGPGAHAGTLKKFELMLHGTREA 85
RRP+DDDSK GF WPFMTTHTWGE+P G W L F G G LK++ LMLHGT+ A
Sbjct: 538 RRPRDDDSKVGFDKWPFMTTHTWGEDPRGTWVLEIGFVGSMPEKGVLKEWTLMLHGTQSA 597
Query: 84 PYNLIEPIVGQTNKKLDTVQK 22
PY I+ IV KL +K
Sbjct: 598 PY--IDQIVRDYQSKLAMSKK 616
>gi|847759|gb|AAA87005.1| subtilisin-related protease SPC2
[Branchiostoma californiense]
Length = 688
Score = 716 bits (1848), Expect = 0.0
Identities = 357/640 (55%), Positives = 442/640 (68%), Gaps = 1/640 (0%)
Frame = -1
Query: 1938 LICVFLSIFIGIGEAVDVYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVAASDNEYHF 1759
L+ + ++ G + YTN F V +++G + A +A+++G++N GQ+ + YHF
Sbjct: 16 LVLATILVWYGACNSAPPYTNDFAVQIRDGKP-DTAELLARKYGYLNLGQIREQRDLYHF 74
Query: 1758 VQPALVHARTRRSAGHHAKLHNDDEVLHVEQLKGYTRTKRGYRPLEQRLESQFDFSAVMS 1579
+ H R RRSA ++L ND V Q +G+ R KRGY + Q D +
Sbjct: 75 RHRGVPHVRRRRSAAQQSRLENDMRVRAAVQQQGFRRRKRGYNEVNDNYR-QIDIN---- 129
Query: 1578 PSDPLYGYQWYLKNTGQAGGKARLDLNVERAWAMGFTGKNITTAIMDDGVDYMHPDIKNN 1399
DPL+ QWYL NTGQA GKA LDLNV AW MG+TG+ +T AIMDDGVDY+HPD+ +N
Sbjct: 130 --DPLFPKQWYLLNTGQADGKAGLDLNVLEAWGMGYTGEGVTIAIMDDGVDYLHPDLADN 187
Query: 1398 FNAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRM 1219
+NA+ASYDFSSN+ FPYPRYTDDWFNSHGTRCAGE+V +NG+CGVGV Y +VAGIRM
Sbjct: 188 YNADASYDFSSNEAFPYPRYTDDWFNSHGTRCAGEVVGKINNGLCGVGVRYGARVAGIRM 247
Query: 1218 LDQPYMTDLIEANSMGHEPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRNGL 1039
LDQP+MTD+IEA+SMGH+P +I IYSA+WGPTDDG+TVDGPR T++A+ GVN+GR G
Sbjct: 248 LDQPFMTDIIEASSMGHKPQEIDIYSATWGPTDDGRTVDGPRELTVQAMADGVNKGRGGK 307
Query: 1038 GSIFVWASXXXXXXXXXXXXGYAASMWTISINSAINNGENAHYDESCSSTLASTFSNG-G 862
GSI+VWAS GYA+SMWTISINSAIN+G A YDESCSSTLASTFSNG
Sbjct: 308 GSIYVWASGDGGSQDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRN 367
Query: 861 RNPETGVATTDLYGRCTRSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLTSSRN 682
R+PE GVATTDLYG CT HSGTSAAAPEAAGVFALAL+ANP+LTWRD+QHLTVLTS RN
Sbjct: 368 RHPEAGVATTDLYGNCTLKHSGTSAAAPEAAGVFALALQANPNLTWRDMQHLTVLTSKRN 427
Query: 681 SLFDGRCRDFPSLGINDNHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLAMA 502
L+D EW+ NGVGLE+NHLFGFGVLDA MV +A
Sbjct: 428 QLYD----------------------PVHEWRRNGVGLEFNHLFGFGVLDAGSMVKMAED 465
Query: 501 WKTSPPRYHCTAGLIDTPHEIPADGNLILEINTDGCAGSQFEVRYLEHVQAVVSFNSTRR 322
W T P R+HCT + IP +G +++++ TD C G + VRYLEHVQAVV+ STRR
Sbjct: 466 WNTVPKRFHCTGTSMSDAKPIPVEGKVVVKLTTDACEGQENFVRYLEHVQAVVTLRSTRR 525
Query: 321 GDTTLYLISPMGTRTMILSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARFQGPG 142
GD + + SPMGT++++LS RP DDDS GF WPFMTTHTWGE+P G W L FQG
Sbjct: 526 GDVNINMASPMGTQSILLSTRPNDDDSVKGFDRWPFMTTHTWGEDPRGDWVLEVGFQGDE 585
Query: 141 AHAGTLKKFELMLHGTREAPYNLIEPIVGQTNKKLDTVQK 22
G L ++ L LHGT+ APY I+ +V + + KL +K
Sbjct: 586 PQEGDLLEWTLRLHGTQSAPY--IDQVVDEWHTKLGMEKK 623
>gi|189652|gb|AAA60032.1| endoprotease
Length = 638
Score = 715 bits (1846), Expect = 0.0
Identities = 360/623 (57%), Positives = 436/623 (69%), Gaps = 1/623 (0%)
Frame = -1
Query: 1887 VYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVAASDNEYHFVQPALVHARTRRSAGHH 1708
V+TNHF V L +GG + A ++A HGF R ++ ++ YHF L A+ RRS H
Sbjct: 29 VFTNHFLVELHKGGE-DKARQVAAEHGFGVR-KLPFAEGLYHFYHNGLAKAKRRRSLHHK 86
Query: 1707 AKLHNDDEVLHVEQLKGYTRTKRGYRPLEQRLESQFDFSAVMSPSDPLYGYQWYLKNTGQ 1528
+L D V Q +G+ R KRGYR + + ++ +DPL+ QWYL NTGQ
Sbjct: 87 QQLERDPRVKMALQQEGFDRKKRGYRDINE---------IDINMNDPLFTKQWYLINTGQ 137
Query: 1527 AGGKARLDLNVERAWAMGFTGKNITTAIMDDGVDYMHPDIKNNFNAEASYDFSSNDPFPY 1348
A G LDLNV AW +G+TGK +T IMDDG+DY+HPD+ +N+NAEASYDFSSNDP+PY
Sbjct: 138 ADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPY 197
Query: 1347 PRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRMLDQPYMTDLIEANSMGH 1168
PRYTDDWFNSHGTRCAGE+ AA +N +CGVGVAY+ KVAGIRMLDQP+MTD+IEA+S+ H
Sbjct: 198 PRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISH 257
Query: 1167 EPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRNGLGSIFVWASXXXXXXXXX 988
P I IYSASWGPTD+GKTVDGPR+ T++A+ GVN+GR G GSI+VWAS
Sbjct: 258 MPQLIDIYSASWGPTDNGKTVDGPRDVTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDC 317
Query: 987 XXXGYAASMWTISINSAINNGENAHYDESCSSTLASTFSNG-GRNPETGVATTDLYGRCT 811
GYA+SMWTISINSAIN+G A YDESCSSTLASTFSNG RNPE GVATTDLYG CT
Sbjct: 318 NCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCT 377
Query: 810 RSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLTSSRNSLFDGRCRDFPSLGIND 631
HSGTSAAAPEAAGVFALALEAN LTWRD+QHLTVLTS RN L
Sbjct: 378 LRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQL--------------- 422
Query: 630 NHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLAMAWKTSPPRYHCTAGLIDT 451
H + H +W+ NGVGLE+NHLFG+GVLDA MV +A WKT P R+HC G +
Sbjct: 423 -HDEVH------QWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQD 475
Query: 450 PHEIPADGNLILEINTDGCAGSQFEVRYLEHVQAVVSFNSTRRGDTTLYLISPMGTRTMI 271
P +IP+ G L+L + TD C G + VRYLEHVQAV++ N+TRRGD + + SPMGT++++
Sbjct: 476 PEKIPSTGKLVLTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSIL 535
Query: 270 LSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARFQGPGAHAGTLKKFELMLHGTR 91
LSRRP+DDDSK GF WPFMTTHTWGE+ G W L F G G LK++ LMLHGT+
Sbjct: 536 LSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGVLKEWTLMLHGTQ 595
Query: 90 EAPYNLIEPIVGQTNKKLDTVQK 22
APY I+ +V KL +K
Sbjct: 596 SAPY--IDQVVRDYQSKLAMSKK 616
>gi|46092402|dbj|BAD14307.1| proprotein convertase type 2 [Oryzias
latipes]
Length = 641
Score = 715 bits (1845), Expect = 0.0
Identities = 364/644 (56%), Positives = 444/644 (68%), Gaps = 1/644 (0%)
Frame = -1
Query: 1950 THVDLICVFLSIFIGIGEAVDVYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVAASDN 1771
T V ++ + ++ A V T H V L E ++AH++A +H F + ++ D
Sbjct: 9 TAVGVLVLLNALLFATEAAEGVLTEHLLVQLHEDAQ-DEAHQLAAQHEFQSARKLPFGDG 67
Query: 1770 EYHFVQPALVHARTRRSAGHHAKLHNDDEVLHVEQLKGYTRTKRGYRPLEQRLESQFDFS 1591
+HF R++RSA L N+ V +V + +G+ R KRGYR +
Sbjct: 68 LFHFYPQDTSKRRSKRSARIKQWLQNNRRVKNVIEQEGFRRQKRGYRNIND--------- 118
Query: 1590 AVMSPSDPLYGYQWYLKNTGQAGGKARLDLNVERAWAMGFTGKNITTAIMDDGVDYMHPD 1411
++ SDPL+ QWYL NTGQA G LDLNV AW +G+TGK +T AIMDDG+DY+HPD
Sbjct: 119 IEVNMSDPLFTKQWYLINTGQADGTPGLDLNVAEAWQLGYTGKGVTIAIMDDGIDYLHPD 178
Query: 1410 IKNNFNAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVA 1231
+ +N+NA+ASYDFSSNDPFP+PRYTDDWFNSHGTRCAGE+ AA +N +CGVGVAY+ KVA
Sbjct: 179 LASNYNADASYDFSSNDPFPFPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVA 238
Query: 1230 GIRMLDQPYMTDLIEANSMGHEPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEG 1051
GIRMLDQP+MTD+IEA+S+ H P I IYSASWGPTDDGKTVDGPR T++A+ GVN+G
Sbjct: 239 GIRMLDQPFMTDIIEASSISHMPQTIDIYSASWGPTDDGKTVDGPRELTLQAMADGVNKG 298
Query: 1050 RNGLGSIFVWASXXXXXXXXXXXXGYAASMWTISINSAINNGENAHYDESCSSTLASTFS 871
R G GSI+VWAS GYA+SMWTISINSAIN+G A YDESCSSTLASTFS
Sbjct: 299 RGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFS 358
Query: 870 NG-GRNPETGVATTDLYGRCTRSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLT 694
NG RNPE GVATTDLYG CT HSGTSAAAPEAAGVFALALEANP+LTWRD+QHL+VLT
Sbjct: 359 NGRKRNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANPNLTWRDMQHLSVLT 418
Query: 693 SSRNSLFDGRCRDFPSLGINDNHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVM 514
S RN L H + H +W+ NGVGLE+NHLFG+GVLDA MV
Sbjct: 419 SKRNQL----------------HDEVH------QWRRNGVGLEFNHLFGYGVLDAGGMVK 456
Query: 513 LAMAWKTSPPRYHCTAGLIDTPHEIPADGNLILEINTDGCAGSQFEVRYLEHVQAVVSFN 334
+A WKT P R+HC AG I PH+I + L+L INT+ C G VRYLEHVQAVV+ N
Sbjct: 457 MAKEWKTVPERFHCVAGSIQEPHKIQSGNKLVLAINTEACEGKDNFVRYLEHVQAVVTVN 516
Query: 333 STRRGDTTLYLISPMGTRTMILSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARF 154
+TRRGD + + SPMGT++++LSRRP+DDDSK GF WPFMTTHTWGE+P G W L F
Sbjct: 517 ATRRGDLNINMTSPMGTKSLLLSRRPRDDDSKVGFDKWPFMTTHTWGEDPRGTWVLEVGF 576
Query: 153 QGPGAHAGTLKKFELMLHGTREAPYNLIEPIVGQTNKKLDTVQK 22
QG G LK++ +MLHGT+ APY I+ IV KL +K
Sbjct: 577 QGDQPQRGVLKEWTVMLHGTQSAPY--IDQIVRDYQSKLAMSKK 618
>gi|417351|sp|Q03333|NEC2_PIG NEUROENDOCRINE CONVERTASE 2 PRECURSOR
(NEC 2) (PC2) (PROHORMONE CONVERTASE 2) (PROPROTEIN
CONVERTASE 2) (KEX2-LIKE ENDOPROTEASE 2)
gi|478767|pir||S29244 proprotein convertase 2 (EC 3.4.21.94)
precursor [similarity] - pig
gi|2032|emb|CAA48593.1| pro-hormone convertase [Sus scrofa]
Length = 638
Score = 715 bits (1845), Expect = 0.0
Identities = 359/623 (57%), Positives = 435/623 (69%), Gaps = 1/623 (0%)
Frame = -1
Query: 1887 VYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVAASDNEYHFVQPALVHARTRRSAGHH 1708
V+TNHF V L +GG E+A ++A HGF R ++ ++ YHF L A+ RRS H
Sbjct: 29 VFTNHFLVELHKGGE-EEARQVAAEHGFGVR-KLPFAEGLYHFYHNGLAKAKRRRSLHHK 86
Query: 1707 AKLHNDDEVLHVEQLKGYTRTKRGYRPLEQRLESQFDFSAVMSPSDPLYGYQWYLKNTGQ 1528
+L D V Q +G+ R KRGYR + + ++ +DPL+ QWYL NTGQ
Sbjct: 87 QRLERDPRVKRALQQEGFDRKKRGYRDINE---------IDINMNDPLFTKQWYLINTGQ 137
Query: 1527 AGGKARLDLNVERAWAMGFTGKNITTAIMDDGVDYMHPDIKNNFNAEASYDFSSNDPFPY 1348
A G LDLNV AW +G+TGK +T IMDDG+DY+HPD+ +N+NAEASYDFSSNDP+PY
Sbjct: 138 ADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPY 197
Query: 1347 PRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRMLDQPYMTDLIEANSMGH 1168
PRYTDDWFNSHGTRCAGE+ AA +N +CGVGVAY KVAGIRMLDQP+MTD+IEA+S+ H
Sbjct: 198 PRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYSSKVAGIRMLDQPFMTDIIEASSISH 257
Query: 1167 EPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRNGLGSIFVWASXXXXXXXXX 988
P I IYSASWGPTD+GKTVDGPR T++A+ GVN+GR G GSI+VWAS
Sbjct: 258 MPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDC 317
Query: 987 XXXGYAASMWTISINSAINNGENAHYDESCSSTLASTFSNG-GRNPETGVATTDLYGRCT 811
GYA+SMWTISINSAIN+G A YDESCSSTLASTFSNG RNPE GVATTDLYG CT
Sbjct: 318 NCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCT 377
Query: 810 RSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLTSSRNSLFDGRCRDFPSLGIND 631
HSGTSAAAPEAAGVFALALEAN LTWRD+QHLTVLTS RN L
Sbjct: 378 LRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQL--------------- 422
Query: 630 NHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLAMAWKTSPPRYHCTAGLIDT 451
H + H +W+ NGVGLE+NHLFG+GVLDA MV +A WKT P R+HC G +
Sbjct: 423 -HDEVH------QWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQD 475
Query: 450 PHEIPADGNLILEINTDGCAGSQFEVRYLEHVQAVVSFNSTRRGDTTLYLISPMGTRTMI 271
P +IP+ G L+L + TD C G + VRYLEHVQAV++ N+TRRGD + + SPMGT++++
Sbjct: 476 PEKIPSTGKLVLTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSIL 535
Query: 270 LSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARFQGPGAHAGTLKKFELMLHGTR 91
LSRRP+DDDSK GF WPFMTTHTWGE+ G W L F G G +K++ LMLHG++
Sbjct: 536 LSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGAVKEWTLMLHGSQ 595
Query: 90 EAPYNLIEPIVGQTNKKLDTVQK 22
APY I+ +V KL +K
Sbjct: 596 SAPY--IDQVVRDYQSKLAMSKK 616
>gi|20336244|ref|NP_002585.2| proprotein convertase subtilisin/kexin
type 2; KEX2-like endoprotease 2; subtilisin-like
prohormone convertases; prohormone convertase 2;
neuroendocrine convertase 2 [Homo sapiens]
gi|13124785|sp|P16519|NEC2_HUMAN Neuroendocrine convertase 2
precursor (NEC 2) (PC2) (Prohormone convertase 2)
(Proprotein convertase 2) (KEX2-like endoprotease 2)
gi|1070499|pir||KXHUC2 proprotein convertase 2 (EC 3.4.21.94)
precursor - human
gi|189131|gb|AAA59919.1| neuroendocrine convertase 2
gi|913908|gb|AAB32656.1| prohormone convertase 2, PC2 [human,
Peptide, 638 aa]
gi|13543298|gb|AAH05815.1| Proprotein convertase subtilisin/kexin
type 2 [Homo sapiens]
Length = 638
Score = 714 bits (1844), Expect = 0.0
Identities = 360/623 (57%), Positives = 435/623 (69%), Gaps = 1/623 (0%)
Frame = -1
Query: 1887 VYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVAASDNEYHFVQPALVHARTRRSAGHH 1708
V+TNHF V L +GG + A ++A HGF R ++ ++ YHF L A+ RRS H
Sbjct: 29 VFTNHFLVELHKGGE-DKARQVAAEHGFGVR-KLPFAEGLYHFYHNGLAKAKRRRSLHHK 86
Query: 1707 AKLHNDDEVLHVEQLKGYTRTKRGYRPLEQRLESQFDFSAVMSPSDPLYGYQWYLKNTGQ 1528
+L D V Q +G+ R KRGYR + + ++ +DPL+ QWYL NTGQ
Sbjct: 87 QQLERDPRVKMALQQEGFDRKKRGYRDINE---------IDINMNDPLFTKQWYLINTGQ 137
Query: 1527 AGGKARLDLNVERAWAMGFTGKNITTAIMDDGVDYMHPDIKNNFNAEASYDFSSNDPFPY 1348
A G LDLNV AW +G+TGK +T IMDDG+DY+HPD+ +N+NAEASYDFSSNDP+PY
Sbjct: 138 ADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPY 197
Query: 1347 PRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRMLDQPYMTDLIEANSMGH 1168
PRYTDDWFNSHGTRCAGE+ AA +N +CGVGVAY+ KVAGIRMLDQP+MTD+IEA+S+ H
Sbjct: 198 PRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISH 257
Query: 1167 EPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRNGLGSIFVWASXXXXXXXXX 988
P I IYSASWGPTD+GKTVDGPR T++A+ GVN+GR G GSI+VWAS
Sbjct: 258 MPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDC 317
Query: 987 XXXGYAASMWTISINSAINNGENAHYDESCSSTLASTFSNG-GRNPETGVATTDLYGRCT 811
GYA+SMWTISINSAIN+G A YDESCSSTLASTFSNG RNPE GVATTDLYG CT
Sbjct: 318 NCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCT 377
Query: 810 RSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLTSSRNSLFDGRCRDFPSLGIND 631
HSGTSAAAPEAAGVFALALEAN LTWRD+QHLTVLTS RN L
Sbjct: 378 LRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQL--------------- 422
Query: 630 NHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLAMAWKTSPPRYHCTAGLIDT 451
H + H +W+ NGVGLE+NHLFG+GVLDA MV +A WKT P R+HC G +
Sbjct: 423 -HDEVH------QWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQD 475
Query: 450 PHEIPADGNLILEINTDGCAGSQFEVRYLEHVQAVVSFNSTRRGDTTLYLISPMGTRTMI 271
P +IP+ G L+L + TD C G + VRYLEHVQAV++ N+TRRGD + + SPMGT++++
Sbjct: 476 PEKIPSTGKLVLTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSIL 535
Query: 270 LSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARFQGPGAHAGTLKKFELMLHGTR 91
LSRRP+DDDSK GF WPFMTTHTWGE+ G W L F G G LK++ LMLHGT+
Sbjct: 536 LSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGVLKEWTLMLHGTQ 595
Query: 90 EAPYNLIEPIVGQTNKKLDTVQK 22
APY I+ +V KL +K
Sbjct: 596 SAPY--IDQVVRDYQSKLAMSKK 616
>gi|30584695|gb|AAP36600.1| Homo sapiens proprotein convertase
subtilisin/kexin type 2 [synthetic construct]
Length = 639
Score = 714 bits (1844), Expect = 0.0
Identities = 360/623 (57%), Positives = 435/623 (69%), Gaps = 1/623 (0%)
Frame = -1
Query: 1887 VYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVAASDNEYHFVQPALVHARTRRSAGHH 1708
V+TNHF V L +GG + A ++A HGF R ++ ++ YHF L A+ RRS H
Sbjct: 29 VFTNHFLVELHKGGE-DKARQVAAEHGFGVR-KLPFAEGLYHFYHNGLAKAKRRRSLHHK 86
Query: 1707 AKLHNDDEVLHVEQLKGYTRTKRGYRPLEQRLESQFDFSAVMSPSDPLYGYQWYLKNTGQ 1528
+L D V Q +G+ R KRGYR + + ++ +DPL+ QWYL NTGQ
Sbjct: 87 QQLERDPRVKMALQQEGFDRKKRGYRDINE---------IDINMNDPLFTKQWYLINTGQ 137
Query: 1527 AGGKARLDLNVERAWAMGFTGKNITTAIMDDGVDYMHPDIKNNFNAEASYDFSSNDPFPY 1348
A G LDLNV AW +G+TGK +T IMDDG+DY+HPD+ +N+NAEASYDFSSNDP+PY
Sbjct: 138 ADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPY 197
Query: 1347 PRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRMLDQPYMTDLIEANSMGH 1168
PRYTDDWFNSHGTRCAGE+ AA +N +CGVGVAY+ KVAGIRMLDQP+MTD+IEA+S+ H
Sbjct: 198 PRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISH 257
Query: 1167 EPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRNGLGSIFVWASXXXXXXXXX 988
P I IYSASWGPTD+GKTVDGPR T++A+ GVN+GR G GSI+VWAS
Sbjct: 258 MPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDC 317
Query: 987 XXXGYAASMWTISINSAINNGENAHYDESCSSTLASTFSNG-GRNPETGVATTDLYGRCT 811
GYA+SMWTISINSAIN+G A YDESCSSTLASTFSNG RNPE GVATTDLYG CT
Sbjct: 318 NCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCT 377
Query: 810 RSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLTSSRNSLFDGRCRDFPSLGIND 631
HSGTSAAAPEAAGVFALALEAN LTWRD+QHLTVLTS RN L
Sbjct: 378 LRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQL--------------- 422
Query: 630 NHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLAMAWKTSPPRYHCTAGLIDT 451
H + H +W+ NGVGLE+NHLFG+GVLDA MV +A WKT P R+HC G +
Sbjct: 423 -HDEVH------QWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQD 475
Query: 450 PHEIPADGNLILEINTDGCAGSQFEVRYLEHVQAVVSFNSTRRGDTTLYLISPMGTRTMI 271
P +IP+ G L+L + TD C G + VRYLEHVQAV++ N+TRRGD + + SPMGT++++
Sbjct: 476 PEKIPSTGKLVLTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSIL 535
Query: 270 LSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARFQGPGAHAGTLKKFELMLHGTR 91
LSRRP+DDDSK GF WPFMTTHTWGE+ G W L F G G LK++ LMLHGT+
Sbjct: 536 LSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGVLKEWTLMLHGTQ 595
Query: 90 EAPYNLIEPIVGQTNKKLDTVQK 22
APY I+ +V KL +K
Sbjct: 596 SAPY--IDQVVRDYQSKLAMSKK 616
>gi|283589|pir||S27270 proprotein convertase 2 (EC 3.4.21.94)
precursor [similarity] - great pond snail
gi|312577|emb|CAA48730.1| LPC2 [Lymnaea stagnalis]
Length = 653
Score = 714 bits (1843), Expect = 0.0
Identities = 367/652 (56%), Positives = 448/652 (68%), Gaps = 10/652 (1%)
Frame = -1
Query: 1938 LICVFLSIFIGIGEAVDVYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVAASDNEYHF 1759
L+C +S+ G+G+ DV TNH+ V L GG + A R+A+ GF G + S +E+HF
Sbjct: 18 LLCWAISV-PGLGKEFDVATNHWLVELTHDGGEDVARRVARETGFTYIGPLLGSKSEFHF 76
Query: 1758 VQPALVHARTRRSAGHHAKLHNDDEVLHVEQLKGYTRTKRGYRPLEQRLESQFDFSAVMS 1579
+ HAR++RS H +L +V Q GY R KRGY+ + L + +
Sbjct: 77 THAGVPHARSKRSIPHTRQLRVHPQVRTAYQQSGYMRVKRGYKDAAKLLTVNKQHIGLKA 136
Query: 1578 ----PSDPLYGYQWYLKNTGQAGGKARLDLNVERAWAMGFTGKNITTAIMDDGVDYMHPD 1411
P+DP + QWYL+NTGQ+GG LDLNV AW MG++G +TTAIMDDG+DY+H D
Sbjct: 137 KPKLPNDPDFDKQWYLRNTGQSGGVKGLDLNVMAAWEMGYSGAGVTTAIMDDGIDYLHED 196
Query: 1410 IKNNFNAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVA 1231
+KNN++A+ASYDFSSNDP+PYPRYTD WFNSHGTRCAGE+ AA+DNGVCGVGVAY KVA
Sbjct: 197 LKNNYHADASYDFSSNDPYPYPRYTDTWFNSHGTRCAGEVSAAKDNGVCGVGVAYGSKVA 256
Query: 1230 GIRMLDQPYMTDLIEANSMGHEPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEG 1051
G+RMLDQP+MTDLIEAN+MGH P+ I IYSASWGPTDDGKTVDGPRN TMRAIV GVN G
Sbjct: 257 GLRMLDQPFMTDLIEANAMGHMPNVIDIYSASWGPTDDGKTVDGPRNLTMRAIVNGVNNG 316
Query: 1050 RNGLGSIFVWASXXXXXXXXXXXXGYAASMWTISINSAINNGENAHYDESCSSTLASTFS 871
RNGLG+++VWAS GYAASMWTISINSA N+G+ A YDESCSSTLASTFS
Sbjct: 317 RNGLGNVYVWASGDGGPNDDCNCDGYAASMWTISINSARNDGQTAGYDESCSSTLASTFS 376
Query: 870 NGGRNP-ETGVATTDLYGRCTRSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLT 694
NG N + GVATTDLY CT SHSGTSAAAPEAAGVFALALEAN +LTWRD+QHLTVLT
Sbjct: 377 NGKSNSRDAGVATTDLYNNCTASHSGTSAAAPEAAGVFALALEANRNLTWRDMQHLTVLT 436
Query: 693 SSRNSLFDGRCRDFPSLGINDNHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVM 514
S RNSL+D S GI+ W++NG L +NHLFG+GVLDAA MV
Sbjct: 437 SKRNSLYD-------SNGIH-------------HWKLNGAHLLFNHLFGYGVLDAASMVD 476
Query: 513 LAMAWKTSPPRYHCTAGLIDTPHEIPADGNLILEINTDGCAGSQFEVRYLEHVQAVVSFN 334
LA W+ P R+HC AG + E L + I +DGC G++ EV YLEHVQA ++
Sbjct: 477 LASQWRGLPERFHCKAGTVSAEKEFTFGKPLRMSIESDGCFGTENEVNYLEHVQAFITLR 536
Query: 333 STRRGDTTLYLISPMGTRTMILSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARF 154
ST RG T+Y+ SPMGT +MILS+RP DDD K+GFT WPFMTTHTW E G W L
Sbjct: 537 STYRGCVTMYMTSPMGTTSMILSQRPNDDDDKNGFTRWPFMTTHTWAEMSRGTWTLDIVM 596
Query: 153 Q-----GPGAHAGTLKKFELMLHGTREAPYNLIEPIVGQTNKKLDTVQKAHK 13
+ G K++ L+LHGT+ APY +P + ++KL V++AH+
Sbjct: 597 EPIMGVKTNIETGLFKEWTLVLHGTKTAPY-AKQPADKERHEKLYLVRRAHE 647
>gi|383113|prf||1902230A prohormone convertase
Length = 653
Score = 712 bits (1839), Expect = 0.0
Identities = 366/652 (56%), Positives = 447/652 (68%), Gaps = 10/652 (1%)
Frame = -1
Query: 1938 LICVFLSIFIGIGEAVDVYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVAASDNEYHF 1759
L+C +S+ G+G+ DV TNH+ V L GG + A R+A+ GF G + S +E+HF
Sbjct: 18 LLCWAISV-PGLGKEFDVATNHWLVELTHDGGEDVARRVAREEGFTYIGPLLGSKSEFHF 76
Query: 1758 VQPALVHARTRRSAGHHAKLHNDDEVLHVEQLKGYTRTKRGYRPLEQRLESQFDFSAVMS 1579
+ HAR++RS H +L +V Q GY R KRGY+ + L + +
Sbjct: 77 THAGVPHARSKRSIPHTRQLRVHPQVRTAYQQSGYMRVKRGYKDAAKLLTVNKQHIGLKA 136
Query: 1578 ----PSDPLYGYQWYLKNTGQAGGKARLDLNVERAWAMGFTGKNITTAIMDDGVDYMHPD 1411
P+DP + QWYL+NTGQ+GG LDLNV AW MG++G +TTAIMDDG+DY+H D
Sbjct: 137 KPKLPNDPDFDKQWYLRNTGQSGGVKGLDLNVMAAWEMGYSGAGVTTAIMDDGIDYLHED 196
Query: 1410 IKNNFNAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVA 1231
+KNN++A+ASYDFSSNDP+PYPRYTD WFNSHGTRCAGE+ AA+DNGVCGVGVAY KVA
Sbjct: 197 LKNNYHADASYDFSSNDPYPYPRYTDTWFNSHGTRCAGEVSAAKDNGVCGVGVAYGSKVA 256
Query: 1230 GIRMLDQPYMTDLIEANSMGHEPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEG 1051
G+RMLDQP+MTDLIEAN+MGH P+ I IYSASWGPTDDGKTVDGPRN TMRAIV GVN G
Sbjct: 257 GLRMLDQPFMTDLIEANAMGHMPNVIDIYSASWGPTDDGKTVDGPRNLTMRAIVNGVNNG 316
Query: 1050 RNGLGSIFVWASXXXXXXXXXXXXGYAASMWTISINSAINNGENAHYDESCSSTLASTFS 871
RNGLG+++VWAS GYAASMWTISINSA N+G+ A YDESCSSTLASTFS
Sbjct: 317 RNGLGNVYVWASGDGGPNDDCNCDGYAASMWTISINSARNDGQTAGYDESCSSTLASTFS 376
Query: 870 NGGRNP-ETGVATTDLYGRCTRSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLT 694
NG N + GVATTDLY CT SHSGTSAAAPEAAGV ALALEAN +LTWRD+QHLTVLT
Sbjct: 377 NGKSNSRDAGVATTDLYNNCTASHSGTSAAAPEAAGVLALALEANRNLTWRDMQHLTVLT 436
Query: 693 SSRNSLFDGRCRDFPSLGINDNHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVM 514
S RNSL+D S GI+ W++NG L +NHLFG+GVLDAA MV
Sbjct: 437 SKRNSLYD-------SNGIH-------------HWKLNGAHLLFNHLFGYGVLDAASMVD 476
Query: 513 LAMAWKTSPPRYHCTAGLIDTPHEIPADGNLILEINTDGCAGSQFEVRYLEHVQAVVSFN 334
LA W+ P R+HC AG + E L + I +DGC G++ EV YLEHVQA ++
Sbjct: 477 LASQWRGLPERFHCKAGTVSAEKEFTFGKPLRMSIESDGCFGTENEVNYLEHVQAFITLR 536
Query: 333 STRRGDTTLYLISPMGTRTMILSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARF 154
ST RG T+Y+ SPMGT +MILS+RP DDD K+GFT WPFMTTHTW E G W L
Sbjct: 537 STYRGCVTMYMTSPMGTTSMILSQRPNDDDDKNGFTRWPFMTTHTWAEMSRGTWTLDIVM 596
Query: 153 Q-----GPGAHAGTLKKFELMLHGTREAPYNLIEPIVGQTNKKLDTVQKAHK 13
+ G K++ L+LHGT+ APY +P + ++KL V++AH+
Sbjct: 597 EPIMGVKTNIETGLFKEWTLVLHGTKTAPY-AKQPADKERHEKLYLVRRAHE 647
>gi|416483|emb|CAA42204.1| prepro-hormone convertase 2 [Aplysia
californica]
Length = 653
Score = 712 bits (1838), Expect = 0.0
Identities = 361/620 (58%), Positives = 432/620 (69%), Gaps = 10/620 (1%)
Frame = -1
Query: 1908 GIGEAVDVYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVAASDNEYHFVQPALVHART 1729
G G +DV TNH+ V L GG E A R+A+ GF G V +SD +HFV + HAR+
Sbjct: 27 GHGRQIDVVTNHWLVELSHDGGPELAKRVARDTGFSYVGPVLSSDRTFHFVHHGVAHARS 86
Query: 1728 RRSAGHHAKLHNDDEVLHVEQLKGYTRTKRGYRPLEQRLESQFDFSAVMS----PSDPLY 1561
RRS H +L V+ Q GY+R KRGY+ ++ L++ A + P+DP +
Sbjct: 87 RRSVPHTRQLRVHPHVVSAFQQNGYSRVKRGYKQTDKLLQANKQSFAYKAKPRLPNDPDF 146
Query: 1560 GYQWYLKNTGQAGGKARLDLNVERAWAMGFTGKNITTAIMDDGVDYMHPDIKNNFNAEAS 1381
G QWYL+NTG++GG LDLNV AW MG++G +TTAIMDDG+DY+H D+K N++A+AS
Sbjct: 147 GKQWYLRNTGESGGVKGLDLNVLEAWEMGYSGAGVTTAIMDDGIDYLHEDLKFNYHADAS 206
Query: 1380 YDFSSNDPFPYPRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRMLDQPYM 1201
YDFSSNDP+PYPRYTD WFNSHGTRCAGE+ AA+DNGVCGVGVA+ KVAG+RMLDQP+M
Sbjct: 207 YDFSSNDPYPYPRYTDTWFNSHGTRCAGEVSAAKDNGVCGVGVAFGSKVAGLRMLDQPFM 266
Query: 1200 TDLIEANSMGHEPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRNGLGSIFVW 1021
TDLIEAN+MGH P+ I IYSASWGPTDDGKTVDGPRN TMRAIV GVN GRNGLG+++VW
Sbjct: 267 TDLIEANAMGHMPNVIDIYSASWGPTDDGKTVDGPRNLTMRAIVNGVNNGRNGLGNVYVW 326
Query: 1020 ASXXXXXXXXXXXXGYAASMWTISINSAINNGENAHYDESCSSTLASTFSNG-GRNPETG 844
AS GYAASMWT+SINSA N+G+ A YDESCSSTLASTFSNG + + G
Sbjct: 327 ASGDGGPNDDCNCDGYAASMWTVSINSATNDGQTAGYDESCSSTLASTFSNGKSSSRDAG 386
Query: 843 VATTDLYGRCTRSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLTSSRNSLFDGR 664
VATTDLY CT SHSGTSAAAPEAAGVFALALEAN +LTWRD+QHLTVLTS RNSL+D
Sbjct: 387 VATTDLYNNCTASHSGTSAAAPEAAGVFALALEANKNLTWRDMQHLTVLTSKRNSLYD-- 444
Query: 663 CRDFPSLGINDNHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLAMAWKTSPP 484
S GI+ W++NG L +NHLFG+GVLDAA MV LA WK P
Sbjct: 445 -----SNGIH-------------HWKLNGAHLLFNHLFGYGVLDAASMVDLARQWKGLPE 486
Query: 483 RYHCTAGLIDTPHEIPADGNLILEINTDGCAGSQFEVRYLEHVQAVVSFNSTRRGDTTLY 304
R+HC AG I + + + I TDGC G++ EV YLEHVQA V+ ST RG T+Y
Sbjct: 487 RFHCKAGSITDKQDFSFGNPVRMSIETDGCVGTENEVNYLEHVQAFVTLRSTYRGCVTMY 546
Query: 303 LISPMGTRTMILSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARFQ-----GPGA 139
L SPMGT +MILS+RP DDD K+GFT WPFMTTHTW E G W L +
Sbjct: 547 LTSPMGTTSMILSQRPNDDDDKNGFTRWPFMTTHTWAELSHGTWSLEIVMEPIIGVKTNM 606
Query: 138 HAGTLKKFELMLHGTREAPY 79
G K++ L+LHGT+ PY
Sbjct: 607 ERGVFKEWTLVLHGTKTPPY 626
>gi|453663|gb|AAA27769.1| PC2
Length = 660
Score = 712 bits (1838), Expect = 0.0
Identities = 366/648 (56%), Positives = 442/648 (67%), Gaps = 16/648 (2%)
Frame = -1
Query: 1908 GIGEAVDVYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVAASDNEYHFVQPALVHART 1729
G G +DV TNH+ V L GG E A R+A+ GF G V +SD +HFV + HAR+
Sbjct: 27 GHGRQIDVVTNHWLVELSHDGGPELAKRVARDTGFSYVGPVLSSDRTFHFVHHGVAHARS 86
Query: 1728 RRSAGHHAKLHNDDEVLHVEQLKGYTRTKRGYRPLEQRLESQFDFSAVMS----PSDPLY 1561
RRS H +L V+ Q GY+R KRGY+ ++ L++ A + P+DP +
Sbjct: 87 RRSVPHTRQLRVHPHVVSAFQQNGYSRVKRGYKQTDKLLQANKQSFAYKAKPRLPNDPDF 146
Query: 1560 GYQWYLKNTGQAGGKARLDLNVERAWAMGFTGKNITTAIMDDGVDYMHPDIKNNFNAEAS 1381
G QWYL+NTG++GG LDLNV AW MG++G +TTAIMDDG+DY+H D+K N++A+AS
Sbjct: 147 GKQWYLRNTGESGGVKGLDLNVLEAWEMGYSGAGVTTAIMDDGIDYLHEDLKFNYHADAS 206
Query: 1380 YDFSSNDPFPYPRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRMLDQPYM 1201
YDFSSNDP+PYPRYTD WFNSHGTRCAGE+ AA+DNGVCGVGVA+ KVAG+RMLDQP+M
Sbjct: 207 YDFSSNDPYPYPRYTDTWFNSHGTRCAGEVSAAKDNGVCGVGVAFGSKVAGLRMLDQPFM 266
Query: 1200 TDLIEANSMGHEPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRNGLGSIFVW 1021
TDLIE N+MGH P+ I IYSASWGPTDDGKTVDGPRN TMRAIV GVN GRNGLG+++VW
Sbjct: 267 TDLIERNAMGHMPNVIDIYSASWGPTDDGKTVDGPRNLTMRAIVNGVNNGRNGLGNVYVW 326
Query: 1020 ASXXXXXXXXXXXXGYAASMWTISINSAINNGENAHYDESCSSTLASTFSNG-GRNPETG 844
AS GYAASMWT+SINSA N+G+ A YDESCSSTLASTFSNG + + G
Sbjct: 327 ASGDGGPNDDCNCDGYAASMWTVSINSATNDGQTAGYDESCSSTLASTFSNGKSSSRDAG 386
Query: 843 VATTDLYGRCTRSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLTSSRNSLFDGR 664
VATTDLY CT SHSGTSAAAPEAAGVFALALEAN +LTWRD+QHLTVLTS RNSL+D
Sbjct: 387 VATTDLYNNCTASHSGTSAAAPEAAGVFALALEANKNLTWRDMQHLTVLTSKRNSLYD-- 444
Query: 663 CRDFPSLGINDNHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLAMAWKTSPP 484
S GI+ W++NG L +NHLFG+GVLDAA MV LA WK P
Sbjct: 445 -----SNGIH-------------HWKLNGAHLLFNHLFGYGVLDAASMVDLARQWKGLPE 486
Query: 483 RYHCTAGLIDTPHEIPADGNLILEINTDGCAGSQFEVRYLEHVQAVVSFNSTRRGDTTLY 304
R+HC AG I + + + I TDGC G++ EV YLEHVQA V+ ST RG T+Y
Sbjct: 487 RFHCKAGSITDKQDFSFGNPVRMSIETDGCVGTENEVNYLEHVQAFVTLRSTYRGCVTMY 546
Query: 303 LISPMGTRTMILSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARFQ-----GPGA 139
L SPMGT +MILS+RP DDD K+GFT WPFMTTHTW E G W L +
Sbjct: 547 LTSPMGTTSMILSQRPNDDDDKNGFTRWPFMTTHTWAELSHGTWSLEIVMEPIIGVKTNM 606
Query: 138 HAGTLKKFELMLHGTREAPY------NLIEPIVGQTNKKLDTVQKAHK 13
G K++ L+LHGT+ PY +P +KL V++AH+
Sbjct: 607 ERGVFKEWTLVLHGTKTPPYATKTPPYANQPADKDKQEKLYLVRRAHE 654
>gi|26252123|gb|AAH40546.1| PCSK2 protein [Homo sapiens]
Length = 619
Score = 711 bits (1836), Expect = 0.0
Identities = 359/623 (57%), Positives = 434/623 (69%), Gaps = 1/623 (0%)
Frame = -1
Query: 1887 VYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVAASDNEYHFVQPALVHARTRRSAGHH 1708
V+TNHF V L +GG + A ++A HGF R ++ ++ YHF L A+ RRS H
Sbjct: 10 VFTNHFLVELHKGGE-DKARQVAAEHGFGVR-KLPFAEGLYHFYHNGLAKAKRRRSLHHK 67
Query: 1707 AKLHNDDEVLHVEQLKGYTRTKRGYRPLEQRLESQFDFSAVMSPSDPLYGYQWYLKNTGQ 1528
+L D V Q +G+ R KRGYR + + ++ +DPL+ QWYL NTGQ
Sbjct: 68 QQLERDPRVKMALQQEGFDRKKRGYRDINE---------IDINMNDPLFTKQWYLINTGQ 118
Query: 1527 AGGKARLDLNVERAWAMGFTGKNITTAIMDDGVDYMHPDIKNNFNAEASYDFSSNDPFPY 1348
A G LDLNV AW +G+TGK +T IMDDG+DY+HPD+ +N+NAEASYDFSSNDP+PY
Sbjct: 119 ADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPY 178
Query: 1347 PRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRMLDQPYMTDLIEANSMGH 1168
PRYTDDWFNSHGTRCAGE+ AA +N +CGVGVAY+ KVAGIRMLDQ +MTD+IEA+S+ H
Sbjct: 179 PRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQQFMTDIIEASSISH 238
Query: 1167 EPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRNGLGSIFVWASXXXXXXXXX 988
P I IYSASWGPTD+GKTVDGPR T++A+ GVN+GR G GSI+VWAS
Sbjct: 239 MPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDC 298
Query: 987 XXXGYAASMWTISINSAINNGENAHYDESCSSTLASTFSNG-GRNPETGVATTDLYGRCT 811
GYA+SMWTISINSAIN+G A YDESCSSTLASTFSNG RNPE GVATTDLYG CT
Sbjct: 299 NCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCT 358
Query: 810 RSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLTSSRNSLFDGRCRDFPSLGIND 631
HSGTSAAAPEAAGVFALALEAN LTWRD+QHLTVLTS RN L
Sbjct: 359 LRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQL--------------- 403
Query: 630 NHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLAMAWKTSPPRYHCTAGLIDT 451
H + H +W+ NGVGLE+NHLFG+GVLDA MV +A WKT P R+HC G +
Sbjct: 404 -HDEVH------QWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQD 456
Query: 450 PHEIPADGNLILEINTDGCAGSQFEVRYLEHVQAVVSFNSTRRGDTTLYLISPMGTRTMI 271
P +IP+ G L+L + TD C G + VRYLEHVQAV++ N+TRRGD + + SPMGT++++
Sbjct: 457 PEKIPSTGELVLTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSIL 516
Query: 270 LSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARFQGPGAHAGTLKKFELMLHGTR 91
LSRRP+DDDSK GF WPFMTTHTWGE+ G W L F G G LK++ LMLHGT+
Sbjct: 517 LSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGVLKEWTLMLHGTQ 576
Query: 90 EAPYNLIEPIVGQTNKKLDTVQK 22
APY I+ +V KL +K
Sbjct: 577 SAPY--IDQVVRDYQSKLAMSKK 597
>gi|3694954|gb|AAC62503.1| proprotein convertase PC2 precursor [Rana
ridibunda]
Length = 636
Score = 710 bits (1833), Expect = 0.0
Identities = 362/635 (57%), Positives = 436/635 (68%), Gaps = 1/635 (0%)
Frame = -1
Query: 1923 LSIFIGIGEAVDVYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVAASDNEYHFVQPAL 1744
L + + + T + V L+EGG ++A ++A +GF ++ SD+ YHF
Sbjct: 14 LLVMYNVSAHSSLLTQQYLVDLQEGGD-QEATQLAHEYGFAGARKLPFSDSLYHFYDSGA 72
Query: 1743 VHARTRRSAGHHAKLHNDDEVLHVEQLKGYTRTKRGYRPLEQRLESQFDFSAVMSPSDPL 1564
R +RS L +V V Q +G+ R KRGYR + ++ +DPL
Sbjct: 73 TKFRRKRSLKSKNHLSMHPKVRKVVQQEGFDRKKRGYRDIND---------IDINMNDPL 123
Query: 1563 YGYQWYLKNTGQAGGKARLDLNVERAWAMGFTGKNITTAIMDDGVDYMHPDIKNNFNAEA 1384
+ QWYL NTGQA G LDLNV AW +G+TGK +T AIMDDG+DY+HPD+ +N+NAEA
Sbjct: 124 FTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIAIMDDGIDYLHPDLASNYNAEA 183
Query: 1383 SYDFSSNDPFPYPRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRMLDQPY 1204
SYDFSSNDP+PYPRYTDDWFNSHGTRCAGE+ AA +N +CGVGVAYD KVAGIRMLDQP+
Sbjct: 184 SYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYDSKVAGIRMLDQPF 243
Query: 1203 MTDLIEANSMGHEPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRNGLGSIFV 1024
MTD+IEA+S+ H P I IYSASWGPTDDGKTVDGPR T++A+ GVN+GR G GSI+V
Sbjct: 244 MTDIIEASSISHMPQIIDIYSASWGPTDDGKTVDGPRELTLQAMADGVNKGRGGKGSIYV 303
Query: 1023 WASXXXXXXXXXXXXGYAASMWTISINSAINNGENAHYDESCSSTLASTFSNG-GRNPET 847
WAS GYA+SMWTISINSAIN+G A YDESCSSTLASTFSNG RNPE
Sbjct: 304 WASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEA 363
Query: 846 GVATTDLYGRCTRSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLTSSRNSLFDG 667
GVATTDLYG CT HSGTSAAAPEAAGVFALALEANP LTWRDLQHLTVLT+ RN L
Sbjct: 364 GVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANPGLTWRDLQHLTVLTTKRNQL--- 420
Query: 666 RCRDFPSLGINDNHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLAMAWKTSP 487
H + H +W+ NGVGLE+NHLFG+GVLDA MV +A WKT P
Sbjct: 421 -------------HDEVH------KWRRNGVGLEFNHLFGYGVLDAGSMVKMAREWKTVP 461
Query: 486 PRYHCTAGLIDTPHEIPADGNLILEINTDGCAGSQFEVRYLEHVQAVVSFNSTRRGDTTL 307
R+HC G + P +IP++G L+L + TD C G + VRYLEHVQAV S NSTRRG+ +
Sbjct: 462 ERFHCIGGSVQEPRKIPSNGKLMLTLTTDACEGKENFVRYLEHVQAVNSVNSTRRGNLNI 521
Query: 306 YLISPMGTRTMILSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARFQGPGAHAGT 127
+ SPMGT++++LSRRP+DDDSK GF WPFMTTHTWGE+P G W L F G G
Sbjct: 522 NMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDPRGTWVLEIGFVGNMPEKGV 581
Query: 126 LKKFELMLHGTREAPYNLIEPIVGQTNKKLDTVQK 22
LK++ LMLHGT+ APY I+ IV KL +K
Sbjct: 582 LKEWTLMLHGTQSAPY--IDQIVRDYQSKLAMSKK 614
>gi|47223236|emb|CAF98620.1| unnamed protein product [Tetraodon
nigroviridis]
Length = 640
Score = 710 bits (1832), Expect = 0.0
Identities = 359/639 (56%), Positives = 440/639 (68%), Gaps = 1/639 (0%)
Frame = -1
Query: 1935 ICVFLSIFIGIGEAVDVYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVAASDNEYHFV 1756
+ + + + A V T H V L+ G ++AH++A +HGF + Q+ + +HF
Sbjct: 14 MALLAGLLLSTQPAQGVRTEHLLVQLR-GDAQDEAHQLATQHGFQSARQLPFGEGLFHFY 72
Query: 1755 QPALVHARTRRSAGHHAKLHNDDEVLHVEQLKGYTRTKRGYRPLEQRLESQFDFSAVMSP 1576
R +RS +L D V V +G++R KRGYR + ++
Sbjct: 73 PQDASKRRNKRSTHRRQELQKDKRVKDVFVQEGFSRQKRGYRNIND---------IEVNM 123
Query: 1575 SDPLYGYQWYLKNTGQAGGKARLDLNVERAWAMGFTGKNITTAIMDDGVDYMHPDIKNNF 1396
SDPL+ QWYL NTGQA G LDLNV AW +G+TGK +T AIMDDG+DY+HPD+ +N+
Sbjct: 124 SDPLFTKQWYLINTGQADGTPGLDLNVAEAWQLGYTGKGVTIAIMDDGIDYLHPDLASNY 183
Query: 1395 NAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRML 1216
NA+ASYDFSSNDPFP+PRYTDDWFNSHGTRCAGE+ AA +N +CGVGVAY+ KVAGIRML
Sbjct: 184 NADASYDFSSNDPFPFPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRML 243
Query: 1215 DQPYMTDLIEANSMGHEPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRNGLG 1036
DQP+MTD+IEA+S+ H P I IYSASWGPTDDGKTVDGPR T++A+ GVN+GR G G
Sbjct: 244 DQPFMTDVIEASSISHMPQLIDIYSASWGPTDDGKTVDGPRELTLQAMADGVNKGRGGKG 303
Query: 1035 SIFVWASXXXXXXXXXXXXGYAASMWTISINSAINNGENAHYDESCSSTLASTFSNG-GR 859
SI+VWAS GYA+SMWTISINSAIN+G A YDESCSSTLASTFSNG R
Sbjct: 304 SIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKR 363
Query: 858 NPETGVATTDLYGRCTRSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLTSSRNS 679
NPE GVATTDLYG CT HSGTSAAAPEAAGVFALALEANP+LTWRD+QHL+VLTS RN
Sbjct: 364 NPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANPNLTWRDMQHLSVLTSKRNQ 423
Query: 678 LFDGRCRDFPSLGINDNHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLAMAW 499
L H + H +W+ NGVGLE+NHLFG+GVLDA MV +A W
Sbjct: 424 L----------------HDEVH------QWRRNGVGLEFNHLFGYGVLDAGGMVKMAKDW 461
Query: 498 KTSPPRYHCTAGLIDTPHEIPADGNLILEINTDGCAGSQFEVRYLEHVQAVVSFNSTRRG 319
KT P R+HC AG I H+I + L+L INT+ C G VRYLEHVQAVV+ N++RRG
Sbjct: 462 KTVPERFHCVAGSIQETHKIQSGSKLVLAINTEACQGKDNFVRYLEHVQAVVTVNASRRG 521
Query: 318 DTTLYLISPMGTRTMILSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARFQGPGA 139
D ++ + SPMGT++++LSRRP+DDD+K GF WPFMTTHTWGE+P G W L F+G
Sbjct: 522 DLSINMTSPMGTKSILLSRRPRDDDTKVGFDKWPFMTTHTWGEDPRGTWLLEVGFRGKEP 581
Query: 138 HAGTLKKFELMLHGTREAPYNLIEPIVGQTNKKLDTVQK 22
G LK++ LMLHGT+ APY I+ IV KL +K
Sbjct: 582 QHGVLKEWTLMLHGTQSAPY--IDQIVRDFKSKLAMSKK 618
>gi|6679229|ref|NP_032818.1| proprotein convertase subtilisin/kexin
type 2; prohormone convertase 2 [Mus musculus]
gi|128003|sp|P21661|NEC2_MOUSE Neuroendocrine convertase 2 precursor
(NEC 2) (PC2) (Prohormone convertase 2) (Proprotein
convertase 2) (KEX2-like endoprotease 2)
gi|67637|pir||KXMSC2 proprotein convertase 2 (EC 3.4.21.94) precursor
- mouse
gi|198592|gb|AAA39376.1| Kex2 homologue
gi|19548778|gb|AAL90786.1| Kex2-like protein [Mus musculus]
gi|19548780|gb|AAL90787.1| Kex2-like protein [Mus musculus]
gi|33989341|gb|AAH52013.2| Proprotein convertase subtilisin/kexin
type 2 [Mus musculus]
gi|34785737|gb|AAH57348.1| Proprotein convertase subtilisin/kexin
type 2 [Mus musculus]
Length = 637
Score = 708 bits (1828), Expect = 0.0
Identities = 357/623 (57%), Positives = 432/623 (69%), Gaps = 1/623 (0%)
Frame = -1
Query: 1887 VYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVAASDNEYHFVQPALVHARTRRSAGHH 1708
V+TNHF V L + G E+A ++A HGF R ++ ++ YHF L A+ RRS H
Sbjct: 28 VFTNHFLVELHKDGE-EEARQVAAEHGFGVR-KLPFAEGLYHFYHNGLAKAKRRRSLHHK 85
Query: 1707 AKLHNDDEVLHVEQLKGYTRTKRGYRPLEQRLESQFDFSAVMSPSDPLYGYQWYLKNTGQ 1528
+L D + Q +G+ R KRGYR + + ++ +DPL+ QWYL NTGQ
Sbjct: 86 RQLERDPRIKMALQQEGFDRKKRGYRDINE---------IDINMNDPLFTKQWYLFNTGQ 136
Query: 1527 AGGKARLDLNVERAWAMGFTGKNITTAIMDDGVDYMHPDIKNNFNAEASYDFSSNDPFPY 1348
A G LDLNV AW +G+TGK +T IMDDG+DY+HPD+ N+NA+ASYDFSSNDP+PY
Sbjct: 137 ADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLAYNYNADASYDFSSNDPYPY 196
Query: 1347 PRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRMLDQPYMTDLIEANSMGH 1168
PRYTDDWFNSHGTRCAGE+ AA N +CGVGVAY+ KVAGIRMLDQP+MTD+IEA+S+ H
Sbjct: 197 PRYTDDWFNSHGTRCAGEVSAAASNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISH 256
Query: 1167 EPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRNGLGSIFVWASXXXXXXXXX 988
P I IYSASWGPTD+GKTVDGPR T++A+ GVN+GR G GSI+VWAS
Sbjct: 257 MPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDC 316
Query: 987 XXXGYAASMWTISINSAINNGENAHYDESCSSTLASTFSNG-GRNPETGVATTDLYGRCT 811
GYA+SMWTISINSAIN+G A YDESCSSTLASTFSNG RNPE GVATTDLYG CT
Sbjct: 317 NCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCT 376
Query: 810 RSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLTSSRNSLFDGRCRDFPSLGIND 631
HSGTSAAAPEAAGVFALALEAN LTWRD+QHLTVLTS RN L
Sbjct: 377 LRHSGTSAAAPEAAGVFALALEANLDLTWRDMQHLTVLTSKRNQL--------------- 421
Query: 630 NHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLAMAWKTSPPRYHCTAGLIDT 451
H + H +W+ NGVGLE+NHLFG+GVLDA MV +A WKT P R+HC G +
Sbjct: 422 -HDEVH------QWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQN 474
Query: 450 PHEIPADGNLILEINTDGCAGSQFEVRYLEHVQAVVSFNSTRRGDTTLYLISPMGTRTMI 271
P +IP G L+L + T+ C G + VRYLEHVQAV++ N+TRRGD + + SPMGT++++
Sbjct: 475 PEKIPPTGKLVLTLKTNACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSIL 534
Query: 270 LSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARFQGPGAHAGTLKKFELMLHGTR 91
LSRRP+DDDSK GF WPFMTTHTWGE+ G W L F G G LK++ LMLHGT+
Sbjct: 535 LSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGLLKEWTLMLHGTQ 594
Query: 90 EAPYNLIEPIVGQTNKKLDTVQK 22
APY I+ +V KL +K
Sbjct: 595 SAPY--IDQVVRDYQSKLAMSKK 615
>gi|6981342|ref|NP_036878.1| proprotein convertase subtilisin/kexin
type 2 [Rattus norvegicus]
gi|128004|sp|P28841|NEC2_RAT NEUROENDOCRINE CONVERTASE 2 PRECURSOR
(NEC 2) (PC2) (PROHORMONE CONVERTASE 2) (PROPROTEIN
CONVERTASE 2) (KEX2-LIKE ENDOPROTEASE 2)
gi|67638|pir||KXRTC2 proprotein convertase 2 (EC 3.4.21.94) precursor
- rat
gi|203511|gb|AAA40946.1| hormone convertase
Length = 637
Score = 707 bits (1826), Expect = 0.0
Identities = 356/623 (57%), Positives = 432/623 (69%), Gaps = 1/623 (0%)
Frame = -1
Query: 1887 VYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVAASDNEYHFVQPALVHARTRRSAGHH 1708
V+TNHF V L + G E+A ++A HGF R ++ ++ YHF L A+ RRS H
Sbjct: 28 VFTNHFLVELHKDGE-EEARQVAAEHGFGVR-KLPFAEGLYHFYHNGLAKAKRRRSLHHK 85
Query: 1707 AKLHNDDEVLHVEQLKGYTRTKRGYRPLEQRLESQFDFSAVMSPSDPLYGYQWYLKNTGQ 1528
+L D + Q +G+ R KRGYR + + ++ +DPL+ QWYL NTGQ
Sbjct: 86 RQLERDPRIKMALQQEGFDRKKRGYRDINE---------IDINMNDPLFTKQWYLFNTGQ 136
Query: 1527 AGGKARLDLNVERAWAMGFTGKNITTAIMDDGVDYMHPDIKNNFNAEASYDFSSNDPFPY 1348
A G LDLNV AW +G+TGK +T IMDDG+DY+HPD+ N+N++ASYDFSSNDP+PY
Sbjct: 137 ADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLAYNYNSDASYDFSSNDPYPY 196
Query: 1347 PRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRMLDQPYMTDLIEANSMGH 1168
PRYTDDWFNSHGTRCAGE+ AA N +CGVGVAY+ KVAGIRMLDQP+MTD+IEA+S+ H
Sbjct: 197 PRYTDDWFNSHGTRCAGEVSAAASNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISH 256
Query: 1167 EPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRNGLGSIFVWASXXXXXXXXX 988
P I IYSASWGPTD+GKTVDGPR T++A+ GVN+GR G GSI+VWAS
Sbjct: 257 MPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDC 316
Query: 987 XXXGYAASMWTISINSAINNGENAHYDESCSSTLASTFSNG-GRNPETGVATTDLYGRCT 811
GYA+SMWTISINSAIN+G A YDESCSSTLASTFSNG RNPE GVATTDLYG CT
Sbjct: 317 NCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCT 376
Query: 810 RSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLTSSRNSLFDGRCRDFPSLGIND 631
HSGTSAAAPEAAGVFALALEAN LTWRD+QHLTVLTS RN L
Sbjct: 377 LRHSGTSAAAPEAAGVFALALEANVDLTWRDMQHLTVLTSKRNQL--------------- 421
Query: 630 NHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLAMAWKTSPPRYHCTAGLIDT 451
H + H +W+ NGVGLE+NHLFG+GVLDA MV +A WKT P R+HC G +
Sbjct: 422 -HDEVH------QWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQN 474
Query: 450 PHEIPADGNLILEINTDGCAGSQFEVRYLEHVQAVVSFNSTRRGDTTLYLISPMGTRTMI 271
P +IP G L+L + T+ C G + VRYLEHVQAV++ N+TRRGD + + SPMGT++++
Sbjct: 475 PEKIPPTGKLVLTLQTNACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSIL 534
Query: 270 LSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARFQGPGAHAGTLKKFELMLHGTR 91
LSRRP+DDDSK GF WPFMTTHTWGE+ G W L F G G LK++ LMLHGT+
Sbjct: 535 LSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGLLKEWTLMLHGTQ 594
Query: 90 EAPYNLIEPIVGQTNKKLDTVQK 22
APY I+ +V KL +K
Sbjct: 595 SAPY--IDQVVRDYQSKLAMSKK 615
>gi|27806047|ref|NP_776838.1| proprotein convertase subtilisin/kexin
type 2 [Bos taurus]
gi|10441397|gb|AAG17018.1| prohormone convertase 2 [Bos taurus]
Length = 638
Score = 705 bits (1820), Expect = 0.0
Identities = 359/623 (57%), Positives = 429/623 (68%), Gaps = 1/623 (0%)
Frame = -1
Query: 1887 VYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVAASDNEYHFVQPALVHARTRRSAGHH 1708
V+TNHF V L GG E A ++A HGF R ++ ++ YHF L AR RRS H
Sbjct: 29 VFTNHFLVELHRGGE-EKARQVAAEHGFGVR-KLPFAEGLYHFYHNGLAKARRRRSLQHQ 86
Query: 1707 AKLHNDDEVLHVEQLKGYTRTKRGYRPLEQRLESQFDFSAVMSPSDPLYGYQWYLKNTGQ 1528
+L D V Q +G+ R KRGYR + ++ D + +DPL+ QWYL NTGQ
Sbjct: 87 QQLERDPRVKRALQQEGFNRKKRGYRDI-----NEIDINV----NDPLFTKQWYLINTGQ 137
Query: 1527 AGGKARLDLNVERAWAMGFTGKNITTAIMDDGVDYMHPDIKNNFNAEASYDFSSNDPFPY 1348
A G LDLNV AW +G+TGK +T IMDDG+DY+HPD+ +N+NAEASYDFSSNDP+PY
Sbjct: 138 ADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPY 197
Query: 1347 PRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRMLDQPYMTDLIEANSMGH 1168
PRYTDDW NSHGTRCAGE+ AA +N +CGVGVAY KVAGIRMLDQP+MTD+IEA+S+ H
Sbjct: 198 PRYTDDWSNSHGTRCAGEVSAAANNNICGVGVAYGSKVAGIRMLDQPFMTDIIEASSISH 257
Query: 1167 EPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRNGLGSIFVWASXXXXXXXXX 988
P I IYSASWGPTD+GKTVDGPR T++A+ GVN+GR G GSI+VWAS
Sbjct: 258 MPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDC 317
Query: 987 XXXGYAASMWTISINSAINNGENAHYDESCSSTLASTFSNG-GRNPETGVATTDLYGRCT 811
GYA+SMWTISINSAIN+G A YDESCSSTLASTFSNG RNPE GVATTDLYG CT
Sbjct: 318 NCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCT 377
Query: 810 RSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLTSSRNSLFDGRCRDFPSLGIND 631
HSGTSAAAPEAAGVFALALEAN LTWRD+QHLTVLTS RN L
Sbjct: 378 LRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQL--------------- 422
Query: 630 NHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLAMAWKTSPPRYHCTAGLIDT 451
H + H +W+ NGVGLE+NHLFG+GVLDA MV +A WKT P R+HC G +
Sbjct: 423 -HDEVH------QWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQN 475
Query: 450 PHEIPADGNLILEINTDGCAGSQFEVRYLEHVQAVVSFNSTRRGDTTLYLISPMGTRTMI 271
P +IP G +L + TD C G + VRYLEHVQAVV+ N+TRRGD + + SPMGT++++
Sbjct: 476 PEKIPTTGKPVLTLTTDACEGKENFVRYLEHVQAVVTVNATRRGDLNINMTSPMGTKSIL 535
Query: 270 LSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARFQGPGAHAGTLKKFELMLHGTR 91
LSRRP+ DD+K GF WPFMTTHTWGE+ G W L F G G L ++ LMLHGT+
Sbjct: 536 LSRRPRGDDAKVGFDKWPFMTTHTWGEDARGTWILELGFVGSAPQKGVLMEWTLMLHGTQ 595
Query: 90 EAPYNLIEPIVGQTNKKLDTVQK 22
APY I+ +V KL +K
Sbjct: 596 SAPY--IDQVVRDYQSKLAMSKK 616
>gi|205065|gb|AAA41477.1| ORF with similarities to Kex2 and furin
proteins; putative
Length = 638
Score = 701 bits (1810), Expect = 0.0
Identities = 354/624 (56%), Positives = 431/624 (68%), Gaps = 2/624 (0%)
Frame = -1
Query: 1887 VYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVAASDNEYHFVQPALVHARTRRSAGHH 1708
V+TNHF V L + G E+A ++A HGF R ++ ++ YHF L A+ RRS H
Sbjct: 28 VFTNHFLVELHKDGE-EEARQVAAEHGFGVR-KLPFAEGLYHFYHNGLAKAKRRRSLHHK 85
Query: 1707 AKLHNDDEVLHVEQLKGYTRTKRGYRPLEQRLESQFDFSAVMSPSDPLYGYQWYLKNTGQ 1528
+L D + Q +G+ R KRGYR + + ++ +DPL+ QWYL NTGQ
Sbjct: 86 RQLERDPRIKMALQQEGFDRKKRGYRDINE---------IDINMNDPLFTKQWYLFNTGQ 136
Query: 1527 AGGKARLDLNVERAWAMGFTGKNITTAIMDDGVDYMHPDIKNNFNAEASYDFSSNDPFPY 1348
A G LDLNV AW +G+TGK +T IMDDG+DY+HPD+ N+N++ASYDFSSNDP+PY
Sbjct: 137 ADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLAYNYNSDASYDFSSNDPYPY 196
Query: 1347 PRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRMLDQPYMTDLIEANSMGH 1168
PRYTDDWFNSHGTRCAGE+ AA N +CGVGVAY+ KVAGIRMLDQP+MTD+IEA+S+ H
Sbjct: 197 PRYTDDWFNSHGTRCAGEVSAAASNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISH 256
Query: 1167 EPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRNGLGSIFVWASXXXXXXXX- 991
P I IYSASWGPTD+GKTVDGPR T++A+ GVN+GR G GSI+VWAS
Sbjct: 257 MPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDC 316
Query: 990 XXXXGYAASMWTISINSAINNGENAHYDESCSSTLASTFSNG-GRNPETGVATTDLYGRC 814
YA+SMWTISINSAIN+G A +DESCSSTLASTFSNG RNPE GVATTDLYG C
Sbjct: 317 NCDGIYASSMWTISINSAINDGRTALHDESCSSTLASTFSNGRKRNPEAGVATTDLYGNC 376
Query: 813 TRSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLTSSRNSLFDGRCRDFPSLGIN 634
T HSGTSAAAPEAAGVFALALEAN LTWRD+QHLTVLTS RN L
Sbjct: 377 TLRHSGTSAAAPEAAGVFALALEANVDLTWRDMQHLTVLTSKRNQL-------------- 422
Query: 633 DNHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLAMAWKTSPPRYHCTAGLID 454
H + H +W+ NGVGLE+NHLFG+GVLDA MV +A WKT P R+HC G +
Sbjct: 423 --HDEVH------QWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQ 474
Query: 453 TPHEIPADGNLILEINTDGCAGSQFEVRYLEHVQAVVSFNSTRRGDTTLYLISPMGTRTM 274
P +IP G L+L + T+ C G + VRYLEHVQAV++ N+TRRGD + + SPMGT+++
Sbjct: 475 NPEKIPPTGKLVLTLQTNACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSI 534
Query: 273 ILSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARFQGPGAHAGTLKKFELMLHGT 94
+LSRRP+DDDSK GF WPFMTTHTWGE+ G W L F G G LK++ LMLHGT
Sbjct: 535 LLSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGLLKEWTLMLHGT 594
Query: 93 REAPYNLIEPIVGQTNKKLDTVQK 22
+ APY I+ +V KL +K
Sbjct: 595 QSAPY--IDQVVRDYQSKLAMSKK 616
>gi|21832168|dbj|BAC05491.1| prohormone convertase 2 [Halocynthia
roretzi]
Length = 642
Score = 701 bits (1808), Expect = 0.0
Identities = 358/636 (56%), Positives = 427/636 (66%), Gaps = 4/636 (0%)
Frame = -1
Query: 1908 GIGEAVDVYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVAASDNEYHFVQPALVHART 1729
G+ A +V+TN F + LK + +A+ FIN GQ+ SD YHF +
Sbjct: 37 GLASAAEVFTNDFIIKLKPDVEKKYGDELARELEFINHGQIPTSDELYHFQHNQVKSVAP 96
Query: 1728 RRSAGHHAKLHNDDEVLHVEQLKGY-TRTKRGYRP--LEQRLESQFDFSAVMSPSDPLYG 1558
S H +L + +V V Q+KGY R KRGY+P L R + DPLY
Sbjct: 97 SPSFEHLLRLQLNPKVESVYQVKGYDNRLKRGYKPKLLSHRYKGM----------DPLYP 146
Query: 1557 YQWYLKNTGQAGGKARLDLNVERAWAMGFTGKNITTAIMDDGVDYMHPDIKNNFNAEASY 1378
QWYLKNTGQAGG LDLN+ AW +G+TGK + AIMDDG+DY+HPD+++N+ EASY
Sbjct: 147 DQWYLKNTGQAGGIPGLDLNIREAWDLGYTGKGVVVAIMDDGIDYLHPDLRDNYIKEASY 206
Query: 1377 DFSSNDPFPYPRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRMLDQPYMT 1198
DFSSNDP+PYPRYT DW+NSHGTRCAGE+V DNG+CGVGVAY+ KVAGIRMLDQPYMT
Sbjct: 207 DFSSNDPYPYPRYTVDWYNSHGTRCAGEVVGKADNGICGVGVAYNAKVAGIRMLDQPYMT 266
Query: 1197 DLIEANSMGHEPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRNGLGSIFVWA 1018
DL+EA SM H+P I IYSASWGPTDDGKTVDGPR T++AIV GVN+GR+GLGSI+VWA
Sbjct: 267 DLVEAKSMSHKPDLIDIYSASWGPTDDGKTVDGPRRLTLQAIVHGVNKGRHGLGSIYVWA 326
Query: 1017 SXXXXXXXXXXXXGYAASMWTISINSAINNGENAHYDESCSSTLASTFSNGGRN-PETGV 841
S GYA+SMWTISINSA+NNGE A YDESCSSTLASTFSN G P GV
Sbjct: 327 SGDGGAYDDCNCDGYASSMWTISINSAVNNGETAIYDESCSSTLASTFSNSGEPIPGAGV 386
Query: 840 ATTDLYGRCTRSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLTSSRNSLFDGRC 661
ATTDLYG CT HSGTSAAAPEAAGV+ALALEANPSLTWRD+QHLTVLTS+RN L D
Sbjct: 387 ATTDLYGNCTLHHSGTSAAAPEAAGVYALALEANPSLTWRDVQHLTVLTSTRNLLTD--- 443
Query: 660 RDFPSLGINDNHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLAMAWKTSPPR 481
+ +WQ NG G +NHLFGFGVL+A MV +A WKT P R
Sbjct: 444 -------------------ALHQWQTNGAGFSFNHLFGFGVLNAGNMVKMAKKWKTVPAR 484
Query: 480 YHCTAGLIDTPHEIPADGNLILEINTDGCAGSQFEVRYLEHVQAVVSFNSTRRGDTTLYL 301
Y C AG + IP D L+LEI T C G ++YLEHVQAV++ +STRRGD T+ +
Sbjct: 485 YRCEAGRTTKQYIIPTDEVLVLEIETAACEGGN-NIKYLEHVQAVLTLDSTRRGDVTINM 543
Query: 300 ISPMGTRTMILSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARFQGPGAHAGTLK 121
SPM T +++L +RP+DDD+ GFT WPFMTTH WGENP G W L F G G L+
Sbjct: 544 TSPMNTNSILLRKRPRDDDNSQGFTRWPFMTTHAWGENPKGIWTLRIAFSGNMPQQGILR 603
Query: 120 KFELMLHGTREAPYNLIEPIVGQTNKKLDTVQKAHK 13
+ L+LHGT+EAPY + IV KL + + K
Sbjct: 604 ECRLILHGTQEAPY--ADEIVSSDELKLAAITEMEK 637
>gi|50738915|ref|XP_419332.1| PREDICTED: similar to Neuroendocrine
convertase 2 precursor (NEC 2) (PC2) (Prohormone
convertase 2) (Proprotein convertase 2) (KEX2-like
endoprotease 2) [Gallus gallus]
Length = 641
Score = 655 bits (1689), Expect = 0.0
Identities = 343/616 (55%), Positives = 401/616 (64%), Gaps = 31/616 (5%)
Frame = -1
Query: 1776 DNEYHFVQPALVHARTRRSAGHHAKLHNDDEVLHVEQLKGYTRTKRGYRPLEQRLESQFD 1597
D Y+F + R RRS H L D V Q +G++R KRGYR +
Sbjct: 37 DTGYYFYHNGIAKVRRRRSFQHKLHLEKDSRVKKAVQQEGFSRRKRGYRDIND------- 89
Query: 1596 FSAVMSPSDPLYGYQWYLKNTGQAGGKARLDLNVERAWAMGFTGKNITTAIMDD------ 1435
++ +DPL+ QWYL NTGQA G LDLNV AW +G+TGK +T IMDD
Sbjct: 90 --IDINMNDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDAHPSQM 147
Query: 1434 ------------------------GVDYMHPDIKNNFNAEASYDFSSNDPFPYPRYTDDW 1327
GV + NA+ASYDFSSNDP+PYPRYTDDW
Sbjct: 148 LKVLAAITALQSQPLLQLNTQHDIGVPTNLLAVSYRNNAQASYDFSSNDPYPYPRYTDDW 207
Query: 1326 FNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRMLDQPYMTDLIEANSMGHEPSKIHI 1147
FNSHGTRCAGE+ AA +N +CGVGVAY+ KVAGIRMLDQP+MTD+IEA+S+ H P I I
Sbjct: 208 FNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQVIDI 267
Query: 1146 YSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRNGLGSIFVWASXXXXXXXXXXXXGYAA 967
YSASWGPTD+GKTVDGPR T++A+ GVN+GR G GSI+VWAS GYA+
Sbjct: 268 YSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNCDGYAS 327
Query: 966 SMWTISINSAINNGENAHYDESCSSTLASTFSNG-GRNPETGVATTDLYGRCTRSHSGTS 790
SMWTISINSAIN+G A YDESCSSTLASTFSNG RNPE GVATTDLYG CT HSGTS
Sbjct: 328 SMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRHSGTS 387
Query: 789 AAAPEAAGVFALALEANPSLTWRDLQHLTVLTSSRNSLFDGRCRDFPSLGINDNHRDSHG 610
AAAPEAAGVFALALEAN LTWRD+QHLTVLTS RN L D + HR
Sbjct: 388 AAAPEAAGVFALALEANLDLTWRDMQHLTVLTSKRNQLHD------------EVHR---- 431
Query: 609 NCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLAMAWKTSPPRYHCTAGLIDTPHEIPAD 430
W+ NGVGLE+NHLFG+GVLDA MV +A WKT P R+HC G I P +IP
Sbjct: 432 ------WRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSIQEPEKIPPS 485
Query: 429 GNLILEINTDGCAGSQFEVRYLEHVQAVVSFNSTRRGDTTLYLISPMGTRTMILSRRPKD 250
G L+L + TD C G + VRYLEHVQAV++ NSTRRGD + + SPMGT++++LSRRP+D
Sbjct: 486 GKLVLTLTTDACEGKENFVRYLEHVQAVITVNSTRRGDLNINMTSPMGTKSILLSRRPRD 545
Query: 249 DDSKDGFTNWPFMTTHTWGENPTGKWRLVARFQGPGAHAGTLKKFELMLHGTREAPYNLI 70
DDSK GF WPFMTTHTWGE+P G W L F G G LK++ LMLHGT+ APY I
Sbjct: 546 DDSKVGFDKWPFMTTHTWGEDPRGTWVLEIGFVGGVPQRGVLKEWTLMLHGTQSAPY--I 603
Query: 69 EPIVGQTNKKLDTVQK 22
+ IV KL +K
Sbjct: 604 DQIVKDYQSKLAMSKK 619