Homology by BLASTX
BLASTX 2.2.4 [Aug-26-2002]
Query= C55F2_2
(1848 letters)
Database: /home/niguts/usr02/tshini/ykclst/db/nr.seq
1,967,186 sequences; 661,712,633 total letters
Score E
Sequences producing significant alignments: (bits) Value
gi|25145659|ref|NP_741452.1| IMP cyclohydrolase (67.4 kD) (4I663... 1207 0.0
gi|25145656|ref|NP_741451.1| IMP cyclohydrolase (4I663) [Caenorh... 1179 0.0
gi|39595034|emb|CAE70902.1| Hypothetical protein CBG17698 [Caeno... 1130 0.0
gi|29570507|gb|AAL27233.2| Hypothetical protein C55F2.1a [Caenor... 694 0.0
gi|24649832|ref|NP_651305.1| CG11089-PA [Drosophila melanogaster... 683 0.0
gi|49250888|gb|AAH74584.1| Unknown (protein for MGC:69458) [Xeno... 680 0.0
gi|28373618|pdb|1M9N|A Chain A, Crystal Structure Of The Homodim... 679 0.0
gi|45384004|ref|NP_990509.1| 5-aminoimidazole-4-carboxamide-ribo... 679 0.0
gi|48675845|ref|NP_112276.2| 5-aminoimidazole-4-carboxamide ribo... 679 0.0
gi|1263196|gb|AAA97405.1| AICAR formyltransferase/IMP cyclohydro... 678 0.0
gi|20127454|ref|NP_004035.2| 5-aminoimidazole-4-carboxamide ribo... 677 0.0
gi|2541906|dbj|BAA22837.1| 5-aminoimidazole-4-carboxamide ribonu... 676 0.0
gi|37572276|gb|AAH39925.2| 5-aminoimidazole-4-carboxamide ribonu... 674 0.0
gi|27229048|ref|NP_080471.1| 5-aminoimidazole-4-carboxamide ribo... 672 0.0
gi|48734658|gb|AAH72321.1| Unknown (protein for IMAGE:6317471) [... 671 0.0
gi|14278285|pdb|1G8M|A Chain A, Crystal Structure Of Avian Atic,... 668 0.0
gi|31242553|ref|XP_321707.1| ENSANGP00000015783 [Anopheles gambi... 665 0.0
gi|34305305|gb|AAQ63487.1| 5-aminoimidazole-4-carboxamide ribonu... 655 0.0
gi|46439064|gb|EAK98386.1| hypothetical protein CaO19.492 [Candi... 648 0.0
gi|50551513|ref|XP_503230.1| hypothetical protein [Yarrowia lipo... 645 0.0
gi|50311693|ref|XP_455873.1| unnamed protein product [Kluyveromy... 644 0.0
gi|6323768|ref|NP_013839.1| Enzyme of 'de novo' purine biosynthe... 644 0.0
gi|50260232|gb|EAL22891.1| hypothetical protein CNBA6600 [Crypto... 639 0.0
gi|37515243|gb|AAQ91905.1| Hypothetical protein C55F2.1c [Caenor... 639 0.0
gi|49094280|ref|XP_408601.1| hypothetical protein AN4464.2 [Aspe... 633 e-180
gi|12848590|dbj|BAB28011.1| unnamed protein product [Mus musculus] 633 e-180
gi|50284971|ref|XP_444914.1| unnamed protein product [Candida gl... 632 e-180
gi|50424841|ref|XP_461010.1| unnamed protein product [Debaryomyc... 631 e-179
gi|6323056|ref|NP_013128.1| Enzyme of 'de novo' purine biosynthe... 630 e-179
gi|32422769|ref|XP_331828.1| hypothetical protein [Neurospora cr... 622 e-176
gi|46108174|ref|XP_381145.1| conserved hypothetical protein [Gib... 618 e-175
gi|45198731|ref|NP_985760.1| AFR213Cp [Eremothecium gossypii] >g... 613 e-174
gi|38104055|gb|EAA50676.1| hypothetical protein MG04435.4 [Magna... 607 e-172
gi|49068698|ref|XP_398638.1| hypothetical protein UM01023.1 [Ust... 606 e-172
gi|19075527|ref|NP_588027.1| putative 5-aminoimidazole-4-carboxa... 605 e-171
gi|47230601|emb|CAF99794.1| unnamed protein product [Tetraodon n... 605 e-171
gi|7498000|pir||T29605 hypothetical protein C55F2.1 - Caenorhabd... 545 e-153
gi|26345052|dbj|BAC36175.1| unnamed protein product [Mus musculus] 454 e-126
gi|16768972|gb|AAL28705.1| LD12501p [Drosophila melanogaster] 442 e-122
gi|11257038|pir||T43150 probable phosphoribosylaminoimidazolecar... 417 e-115
gi|29345928|ref|NP_809431.1| Bifunctional purine biosynthesis pr... 403 e-111
gi|26338005|dbj|BAC32688.1| unnamed protein product [Mus musculus] 394 e-108
gi|26369191|dbj|BAB26949.2| unnamed protein product [Mus musculus] 393 e-108
gi|15895710|ref|NP_349059.1| AICAR transformylase domain of PurH... 366 e-100
gi|7507262|pir||T16819 hypothetical protein T06C10.1 - Caenorhab... 355 2e-96
gi|27262340|gb|AAN87451.1| phosphoribosylaminoimidazolecarboxami... 301 5e-80
gi|20092807|ref|NP_618882.1| phosphoribosylaminoimidazolecarboxa... 294 4e-78
gi|21227000|ref|NP_632922.1| formyltransferase phosphoribosylami... 294 4e-78
gi|27375692|ref|NP_767221.1| bifunctional purine biosynthesis pr... 290 1e-76
gi|16131836|ref|NP_418434.1| phosphoribosylaminoimidazolecarboxa... 289 2e-76
gi|48841015|ref|ZP_00297941.1| COG0138: AICAR transformylase/IMP... 289 2e-76
gi|24115290|ref|NP_709800.1| phosphoribosylaminoimidazolecarboxa... 288 3e-76
gi|15804597|ref|NP_290638.1| phosphoribosylaminoimidazolecarboxa... 288 3e-76
gi|26250778|ref|NP_756818.1| Purine biosynthesis protein PurH; P... 286 2e-75
gi|15967075|ref|NP_387428.1| PROBABLE BIFUNCTIONAL INCLUDES: PHO... 285 3e-75
gi|39933108|ref|NP_945384.1| bifunctional purine biosynthesis pr... 281 3e-74
gi|48766654|ref|ZP_00271204.1| COG0138: AICAR transformylase/IMP... 279 2e-73
gi|22956468|ref|ZP_00004237.1| COG0138: AICAR transformylase/IMP... 277 7e-73
gi|21673159|ref|NP_661224.1| phosphoribosylaminoimidazolecarboxa... 274 5e-72
gi|15890069|ref|NP_355750.1| AGR_C_5117p [Agrobacterium tumefaci... 274 6e-72
gi|17936698|ref|NP_533488.1| bifunctional purine biosynthesis pr... 274 6e-72
gi|13473487|ref|NP_105054.1| bifunctional purine biosynthesis pr... 271 5e-71
gi|49474769|ref|YP_032811.1| Bifunctional purine biosynthesis pr... 267 7e-70
gi|48833088|ref|ZP_00290112.1| COG0138: AICAR transformylase/IMP... 266 1e-69
gi|21241284|ref|NP_640866.1| bifunctional purine biosynthesis pr... 265 2e-69
gi|48785095|ref|ZP_00281400.1| COG0138: AICAR transformylase/IMP... 265 3e-69
gi|28828110|gb|AAO50793.1| similar to Thermoanaerobacter tengcon... 265 4e-69
gi|15600047|ref|NP_253541.1| phosphoribosylaminoimidazolecarboxa... 264 5e-69
gi|32044209|ref|ZP_00141310.1| COG0138: AICAR transformylase/IMP... 264 6e-69
gi|48850323|ref|ZP_00304565.1| COG0138: AICAR transformylase/IMP... 263 1e-68
gi|17545223|ref|NP_518625.1| PROBABLE BIFUNCTIONAL : PHOSPHORIBO... 262 2e-68
gi|16077720|ref|NP_388534.1| inosine-monophosphate cyclohydrolas... 261 4e-68
gi|50085531|ref|YP_047041.1| bifunctional protein [Includes: pho... 260 7e-68
gi|28899670|ref|NP_799275.1| phosphoribosylaminoimidazolecarboxa... 260 7e-68
gi|19704317|ref|NP_603879.1| Phosphoribosylaminoimidazolecarboxa... 259 1e-67
gi|49236529|ref|ZP_00330588.1| COG0138: AICAR transformylase/IMP... 259 1e-67
gi|48767947|ref|ZP_00272299.1| COG0138: AICAR transformylase/IMP... 259 2e-67
gi|46132909|ref|ZP_00171691.2| COG0138: AICAR transformylase/IMP... 259 2e-67
gi|30248880|ref|NP_840950.1| probable phosphoribosylaminoimidazo... 258 3e-67
gi|48870005|ref|ZP_00322737.1| COG0138: AICAR transformylase/IMP... 258 3e-67
gi|42527401|ref|NP_972499.1| phosphoribosylaminoimidazolecarboxa... 258 3e-67
gi|16803805|ref|NP_465290.1| Bifunctional phosphoribosylaminoimi... 257 6e-67
gi|16800943|ref|NP_471211.1| Bifunctional phosphoribosylaminoimi... 256 1e-66
gi|46143527|ref|ZP_00135055.2| COG0138: AICAR transformylase/IMP... 256 1e-66
gi|15838569|ref|NP_299257.1| bifunctional purine biosynthesis pr... 256 1e-66
gi|32129929|sp|Q9PC10|PUR9_XYLFA Bifunctional purine biosynthesi... 256 1e-66
gi|34763390|ref|ZP_00144341.1| PHOSPHORIBOSYLAMINOIMIDAZOLECARBO... 256 1e-66
gi|46316085|ref|ZP_00216665.1| COG0138: AICAR transformylase/IMP... 255 2e-66
gi|46321145|ref|ZP_00221525.1| COG0138: AICAR transformylase/IMP... 255 2e-66
gi|41720176|ref|ZP_00149015.1| COG0138: AICAR transformylase/IMP... 255 2e-66
gi|46113247|ref|ZP_00200726.1| COG0138: AICAR transformylase/IMP... 255 2e-66
gi|48860390|ref|ZP_00314315.1| COG0138: AICAR transformylase/IMP... 255 3e-66
gi|49479086|ref|YP_034620.1| phosphoribosylaminoimidazole carbox... 255 3e-66
gi|30018541|ref|NP_830172.1| IMP cyclohydrolase [Bacillus cereus... 255 3e-66
gi|49476249|ref|YP_034290.1| Bifunctional purine biosynthesis pr... 255 3e-66
gi|16123865|ref|NP_407178.1| bifunctional purine biosynthesis pr... 254 4e-66
gi|22124417|ref|NP_667840.1| phosphoribosylaminoimidazolecarboxa... 254 4e-66
gi|21398245|ref|NP_654230.1| AICARFT_IMPCHas, AICARFT/IMPCHase b... 254 5e-66
gi|47569943|ref|ZP_00240608.1| phosphoribosylaminoimidazolecarbo... 253 8e-66
gi|42779408|ref|NP_976655.1| phosphoribosylaminoimidazolecarboxa... 253 8e-66
gi|23467641|ref|ZP_00123221.1| COG0138: AICAR transformylase/IMP... 253 8e-66
gi|23104499|ref|ZP_00090963.1| COG0138: AICAR transformylase/IMP... 253 8e-66
gi|23098204|ref|NP_691670.1| phosphoribosylaminoimidazolecarboxa... 253 1e-65
gi|39995716|ref|NP_951667.1| phosphoribosylaminoimidazolecarboxa... 253 1e-65
gi|16272827|ref|NP_439048.1| phosphoribosylaminoimidazolecarboxa... 253 1e-65
gi|21229973|ref|NP_635890.1| bifunctional purine biosynthesis pr... 252 2e-65
gi|48865780|ref|ZP_00319638.1| COG0138: AICAR transformylase/IMP... 252 2e-65
gi|16767430|ref|NP_463045.1| phosphoribosylaminoimidazolecarboxa... 252 2e-65
gi|48844690|ref|ZP_00298991.1| COG0138: AICAR transformylase/IMP... 252 2e-65
gi|16124341|ref|NP_418905.1| phosphoribosylaminoimidazolecarboxa... 251 3e-65
gi|50119201|ref|YP_048368.1| bifunctional purine biosynthesis pr... 251 4e-65
gi|42631211|ref|ZP_00156749.1| COG0138: AICAR transformylase/IMP... 251 4e-65
gi|26991502|ref|NP_746927.1| phosphoribosylaminoimidazolecarboxa... 251 5e-65
gi|46907995|ref|YP_014384.1| phosphoribosylaminoimidazolecarboxa... 250 7e-65
gi|29143769|ref|NP_807111.1| phosphoribosylaminoimidazolecarboxa... 249 1e-64
gi|23113954|ref|ZP_00099286.1| COG0138: AICAR transformylase/IMP... 249 2e-64
gi|17986517|ref|NP_539151.1| PHOSPHORIBOSYLAMINOIMIDAZOLECARBOXA... 248 5e-64
gi|20807087|ref|NP_622258.1| AICAR transformylase/IMP cyclohydro... 247 6e-64
gi|16762281|ref|NP_457898.1| phosphoribosylaminoimidazolecarboxa... 247 6e-64
gi|34496001|ref|NP_900216.1| phosphoribosylaminoimidazolecarboxa... 247 6e-64
gi|15606962|ref|NP_214344.1| phosphoribosylaminoimidazolecarboxa... 247 6e-64
gi|33239750|ref|NP_874692.1| AICAR transformylase/IMP cyclohydro... 247 6e-64
gi|46129145|ref|ZP_00155824.2| COG0138: AICAR transformylase/IMP... 246 2e-63
gi|45916762|ref|ZP_00195780.2| COG0138: AICAR transformylase/IMP... 245 3e-63
gi|33864124|ref|NP_895684.1| AICARFT/IMPCHase bienzyme:Methylgly... 245 3e-63
gi|48732254|ref|ZP_00265997.1| COG0138: AICAR transformylase/IMP... 245 3e-63
gi|15640305|ref|NP_229932.1| phosphoribosylaminoimidazolecarboxa... 244 4e-63
gi|22995410|ref|ZP_00039887.1| COG0138: AICAR transformylase/IMP... 244 5e-63
gi|23470747|ref|ZP_00126079.1| COG0138: AICAR transformylase/IMP... 244 5e-63
gi|48825155|ref|ZP_00286439.1| COG0138: AICAR transformylase/IMP... 243 9e-63
gi|28871981|ref|NP_794600.1| phosphoribosylaminoimidazolecarboxa... 243 9e-63
gi|17230585|ref|NP_487133.1| bifunctional purine biosynthesis pr... 243 9e-63
gi|33860824|ref|NP_892385.1| AICARFT/IMPCHase bienzyme:Methylgly... 243 1e-62
gi|27364630|ref|NP_760158.1| AICAR transformylase/IMP cyclohydro... 243 1e-62
gi|28198733|ref|NP_779047.1| bifunctional purine biosynthesis pr... 243 1e-62
gi|37524504|ref|NP_927848.1| phosphoribosylaminoimidazolecarboxa... 242 3e-62
gi|29376325|ref|NP_815479.1| phosphoribosylaminoimidazolecarboxa... 242 3e-62
gi|15602087|ref|NP_245159.1| PurH [Pasteurella multocida Pm70] >... 242 3e-62
gi|24214983|ref|NP_712464.1| IMP cyclohydrolase [Leptospira inte... 241 3e-62
gi|15613196|ref|NP_241499.1| phosphoribosylaminoimidazolecarboxa... 241 3e-62
gi|45657525|ref|YP_001611.1| PurH [Leptospira interrogans serova... 241 3e-62
gi|47574491|ref|ZP_00244527.1| COG0138: AICAR transformylase/IMP... 241 6e-62
gi|15673500|ref|NP_267674.1| bifunctional purine biosynthesis pr... 241 6e-62
gi|23128034|ref|ZP_00109890.1| COG0138: AICAR transformylase/IMP... 240 7e-62
gi|15794127|ref|NP_283949.1| putative bifunctional purine biosyn... 239 1e-61
gi|33602975|ref|NP_890535.1| bifunctional purine biosynthesis pr... 239 2e-61
gi|48890989|ref|ZP_00324573.1| COG0138: AICAR transformylase/IMP... 239 2e-61
gi|37520128|ref|NP_923505.1| phosphoribosyl aminoimidazole carbo... 239 2e-61
gi|33594299|ref|NP_881943.1| bifunctional purine biosynthesis pr... 239 2e-61
gi|22997607|ref|ZP_00041836.1| COG0138: AICAR transformylase/IMP... 238 4e-61
gi|29653686|ref|NP_819378.1| phosphoribosylaminoimidazolecarboxa... 238 4e-61
gi|28379214|ref|NP_786106.1| bifunctional protein: phosphoribosy... 237 8e-61
gi|33598082|ref|NP_885725.1| bifunctional purine biosynthesis pr... 236 1e-60
gi|15676875|ref|NP_274020.1| phosphoribosylaminoimidazolecarboxa... 236 1e-60
gi|41690727|ref|ZP_00147259.1| COG0138: AICAR transformylase/IMP... 236 1e-60
gi|49483237|ref|YP_040461.1| putative bifunctional purine biosyn... 236 2e-60
gi|279479|pir||DTEBPH purH bifunctional enzyme - Salmonella typh... 235 3e-60
gi|15924063|ref|NP_371597.1| bifunctional purine biosynthesis pr... 234 5e-60
gi|21282685|ref|NP_645773.1| bifunctional purine biosynthesis pr... 233 1e-59
gi|49485912|ref|YP_043133.1| putative bifunctional purine biosyn... 233 1e-59
gi|24372037|ref|NP_716079.1| phosphoribosylaminoimidazolecarboxa... 233 2e-59
gi|15792282|ref|NP_282105.1| phosphoribosylaminoimidazolecarboxa... 231 4e-59
gi|32476255|ref|NP_869249.1| bifunctional purine biosynthesis pr... 231 6e-59
gi|46914928|emb|CAG21703.1| putative osphoribosylaminoimidazolec... 231 6e-59
gi|46198869|ref|YP_004536.1| phosphoribosylaminoimidazolecarboxa... 230 8e-59
gi|48861221|ref|ZP_00315125.1| COG0138: AICAR transformylase/IMP... 229 1e-58
gi|32171642|sp|Q8DWK8|PUR9_STRMU Bifunctional purine biosynthesi... 229 2e-58
gi|24378565|ref|NP_720520.1| putative phosphoribosylaminoimidazo... 229 2e-58
gi|48852332|ref|ZP_00306520.1| COG0138: AICAR transformylase/IMP... 229 2e-58
gi|15899995|ref|NP_344599.1| phosphoribosylaminoimidazolecarboxa... 229 2e-58
gi|27467689|ref|NP_764326.1| phosphoribosylaminoimidazolecarboxa... 229 2e-58
gi|38233436|ref|NP_939203.1| bifunctional purine biosynthesis pr... 228 3e-58
gi|22299090|ref|NP_682337.1| phosphoribosyl aminoimidazole carbo... 228 4e-58
gi|21909560|ref|NP_663828.1| putative phosphoribosyl carboxyamid... 228 5e-58
gi|11878280|gb|AAG40879.1| phosphoribosylaminoimidazolecarboxami... 228 5e-58
gi|8927416|gb|AAF82069.1| formyltransferase [Mycobacterium avium... 227 6e-58
gi|6179961|gb|AAF05727.1| PurH [Mycobacterium avium subsp. parat... 227 6e-58
gi|19745224|ref|NP_606360.1| putative phosphoribosyl carboxyamid... 227 8e-58
gi|551903|gb|AAB59070.1| purH 226 1e-57
gi|42520702|ref|NP_966617.1| phosphoribosylaminoimidazolecarboxa... 226 1e-57
gi|41407001|ref|NP_959837.1| PurH [Mycobacterium avium subsp. pa... 225 2e-57
gi|15902095|ref|NP_357645.1| Phosphoribosylaminoimidazolecarboxa... 225 2e-57
gi|32171638|sp|Q8DRM1|PUR9_STRR6 Bifunctional purine biosynthesi... 225 2e-57
gi|45645210|sp|Q9RAJ5|PUR9_MYCPA Bifunctional purine biosynthesi... 225 2e-57
gi|7433571|pir||T00485 probable phosphoribosylaminoimidazolecarb... 224 4e-57
gi|30686280|ref|NP_850240.1| AICARFT/IMPCHase bienzyme family pr... 224 4e-57
gi|15608097|ref|NP_215472.1| purH [Mycobacterium tuberculosis H3... 224 5e-57
gi|42761313|dbj|BAD11556.1| putative aminoimidazolecarboximide r... 224 5e-57
gi|42761312|dbj|BAD11555.1| putative aminoimidazolecarboximide r... 224 7e-57
gi|22536215|ref|NP_687066.1| phosphoribosylaminoimidazolecarboxa... 223 1e-56
gi|32171721|sp|Q9RHX6|PUR9_CORAM Bifunctional purine biosynthesi... 222 2e-56
gi|46106435|ref|ZP_00187243.2| COG0138: AICAR transformylase/IMP... 221 4e-56
gi|18309668|ref|NP_561602.1| bifunctional purine biosynthesis pr... 221 4e-56
gi|15826983|ref|NP_301246.1| putative phosphoribosylaminoimidazo... 221 4e-56
gi|33864785|ref|NP_896344.1| AICARFT/IMPCHase bienzyme:Methylgly... 220 8e-56
gi|25027493|ref|NP_737547.1| phosphoribosylaminoimidazolecarboxa... 220 1e-55
gi|34558180|ref|NP_907995.1| PHOSPHORIBOSYLAMINOIMIDAZOLECARBOXA... 219 1e-55
gi|50591514|ref|ZP_00332823.1| COG0138: AICAR transformylase/IMP... 219 2e-55
gi|2072373|emb|CAA70450.1| phosphoribosylaminoimidazolecarboxami... 218 4e-55
gi|46362943|ref|ZP_00225750.1| COG0138: AICAR transformylase/IMP... 218 4e-55
gi|32172442|sp|P74741|PUR9_SYNY3 Bifunctional purine biosynthesi... 217 7e-55
gi|16332321|ref|NP_443049.1| phosphoribosyl aminoimidazole carbo... 217 7e-55
gi|28412960|gb|AAO40252.1| aminoimidazolecarboximide ribonucleot... 217 7e-55
gi|29349220|ref|NP_812723.1| phosphoribosylaminoimidazole carbox... 216 1e-54
gi|45523332|ref|ZP_00174706.1| COG0138: AICAR transformylase/IMP... 215 3e-54
gi|23465313|ref|NP_695916.1| bifunctional purine biosynthesis pr... 214 4e-54
gi|48105312|ref|XP_395924.1| similar to 5-aminoimidazole-4-carbo... 214 6e-54
gi|19552088|ref|NP_600090.1| phosphoribosylaminoimidazolecarboxa... 214 7e-54
gi|15616660|ref|NP_239872.1| phosphoribosylaminoimidazolecarboxa... 214 7e-54
gi|29829987|ref|NP_824621.1| putative bifunctional purine biosyn... 214 7e-54
gi|50843207|ref|YP_056434.1| Phosphoribosylaminoimidazolecarboxa... 213 1e-53
gi|21672325|ref|NP_660392.1| bifunctional purine biosynthesis pr... 211 4e-53
gi|48836815|ref|ZP_00293810.1| COG0138: AICAR transformylase/IMP... 211 6e-53
gi|21223192|ref|NP_628971.1| bifunctional purine biosynthesis pr... 209 2e-52
gi|15894674|ref|NP_348023.1| AICAR transformylase/IMP cyclohydro... 207 7e-52
gi|28211588|ref|NP_782532.1| phosphoribosylaminoimidazolecarboxa... 206 1e-51
gi|46308297|ref|ZP_00210491.1| COG0138: AICAR transformylase/IMP... 206 2e-51
gi|48477817|ref|YP_023523.1| phosphoribosylaminoimidazolecarboxa... 204 4e-51
gi|46191230|ref|ZP_00206721.1| COG0138: AICAR transformylase/IMP... 204 8e-51
gi|15805894|ref|NP_294592.1| phosphoribosylaminoimidazolecarboxa... 202 2e-50
gi|32171722|sp|Q9RW01|PUR9_DEIRA Bifunctional purine biosynthesi... 202 2e-50
gi|23120370|ref|ZP_00103060.1| COG0138: AICAR transformylase/IMP... 201 6e-50
gi|32171613|sp|Q89B23|PUR9_BUCBP Bifunctional purine biosynthesi... 197 7e-49
gi|28493051|ref|NP_787212.1| phosphoribosylaminoimidazolecarboxa... 197 7e-49
gi|27904544|ref|NP_777670.1| phosphoribosylaminoimidazolecarboxa... 197 7e-49
gi|16081235|ref|NP_393539.1| purH bifunctional enzyme related pr... 196 2e-48
gi|7497695|pir||T34176 hypothetical protein C49H3.7 - Caenorhabd... 194 6e-48
gi|34541079|ref|NP_905558.1| phosphoribosylaminoimidazolecarboxa... 193 1e-47
gi|48856971|ref|ZP_00311128.1| COG0138: AICAR transformylase/IMP... 193 1e-47
gi|32265982|ref|NP_860014.1| AICAR transformylase PurH [Helicoba... 189 3e-46
gi|50876503|emb|CAG36343.1| probable bifunctional purine biosynt... 188 4e-46
gi|33519998|ref|NP_878830.1| phosphoribosylaminoimidazolecarboxa... 185 3e-45
gi|42524398|ref|NP_969778.1| IMP cyclohydrolase [Bdellovibrio ba... 183 1e-44
gi|33152721|ref|NP_874074.1| bifunctional purine biosynthesis pr... 181 5e-44
gi|48867093|ref|ZP_00320711.1| COG0138: AICAR transformylase/IMP... 179 2e-43
gi|32491260|ref|NP_871514.1| purH [Wigglesworthia glossinidia en... 172 2e-41
gi|13540847|ref|NP_110535.1| AICAR transformylase/IMP cyclohydro... 172 3e-41
gi|2145614|pir||S54424 phosphoribosylaminoimidazolecarboxamide f... 159 3e-37
gi|22973685|ref|ZP_00020227.1| hypothetical protein [Chloroflexu... 155 3e-36
gi|46202491|ref|ZP_00208542.1| COG0138: AICAR transformylase/IMP... 150 1e-34
gi|15644005|ref|NP_229054.1| phosphoribosylaminoimidazolecarboxa... 144 7e-33
gi|3248935|gb|AAD09926.1| phosphoribosylaminoimidazolecarboxamid... 144 9e-33
gi|34860201|ref|XP_227632.2| similar to 5-aminoimidazole-4-carbo... 143 1e-32
gi|46202492|ref|ZP_00208543.1| COG0138: AICAR transformylase/IMP... 137 1e-30
gi|23474350|ref|ZP_00129644.1| COG0138: AICAR transformylase/IMP... 136 1e-30
gi|46581637|ref|YP_012445.1| IMP cyclohydrolase, putative [Desul... 131 5e-29
gi|13277324|emb|CAC34383.1| bifunctional protein [Platichthys fl... 108 4e-22
gi|7415859|dbj|BAA93563.1| phosphoribosyl aminoimiddazol carboxa... 104 6e-21
gi|23475684|ref|ZP_00130966.1| COG0138: AICAR transformylase/IMP... 104 6e-21
gi|46581608|ref|YP_012416.1| phosphoribosylaminoimidazolecarboxa... 102 2e-20
gi|50876630|emb|CAG36470.1| related to bifunctional purine biosy... 100 1e-19
gi|15789661|ref|NP_279485.1| phosphoribosylaminoimidazole-succin... 89 5e-16
gi|46254458|gb|AAS86202.1| 5-aminoimidazole-4-carboxamide ribonu... 85 7e-15
gi|48867242|ref|ZP_00320814.1| COG0138: AICAR transformylase/IMP... 75 4e-12
gi|46520130|gb|AAT00453.1| PurH [Xanthomonas oryzae pv. oryzae] 74 1e-11
gi|32028651|ref|ZP_00131807.1| COG0138: AICAR transformylase/IMP... 70 2e-10
gi|41724792|ref|ZP_00151602.1| COG0138: AICAR transformylase/IMP... 69 4e-10
gi|2500021|sp|Q46480|PUR9_CHRVI Bifunctional purine biosynthesis... 69 5e-10
gi|48290845|dbj|BAB63412.2| phosphoribosyl carboxyamide aminoimi... 64 2e-08
gi|48290857|dbj|BAB63433.2| phosphoribosyl carboxyamide aminoimi... 63 2e-08
gi|48290842|dbj|BAB20850.2| phosphoribosyl carboxyamide aminoimi... 63 2e-08
gi|48290854|dbj|BAB63427.2| phosphoribosyl carboxyamide aminoimi... 63 2e-08
gi|31195923|ref|XP_306909.1| ENSANGP00000000436 [Anopheles gambi... 61 1e-07
gi|11499399|ref|NP_070638.1| inosine monophosphate cyclohydrolas... 61 1e-07
gi|2465560|gb|AAB72185.1| phosphoribosylaminoimidazole-carboxami... 60 2e-07
gi|45508763|ref|ZP_00161100.1| COG0138: AICAR transformylase/IMP... 58 7e-07
gi|23115455|ref|ZP_00100516.1| COG0138: AICAR transformylase/IMP... 57 2e-06
gi|45511952|ref|ZP_00163519.1| COG0138: AICAR transformylase/IMP... 55 6e-06
gi|50260348|gb|EAL23007.1| hypothetical protein CNBA7740 [Crypto... 49 5e-04
gi|46206019|ref|ZP_00047798.2| COG0138: AICAR transformylase/IMP... 44 0.013
gi|33322574|gb|AAQ07018.1| phosphoribosylaminoimidazolecarboxami... 44 0.017
gi|20095102|ref|NP_614949.1| Carbamoylphosphate synthase large s... 42 0.038
gi|12082235|dbj|BAB20852.1| phosphoribosyl carboxyamide aminoimi... 42 0.038
gi|33240347|ref|NP_875289.1| Carbamoylphosphate synthase large s... 42 0.050
gi|6552726|gb|AAF16526.1| ADP-forming, carbamate-phosphorylating... 41 0.085
gi|48833419|ref|ZP_00290438.1| COG0138: AICAR transformylase/IMP... 41 0.11
gi|21242606|ref|NP_642188.1| carbamoyl-phosphate synthase large ... 40 0.25
gi|21231291|ref|NP_637208.1| carbamoyl-phosphate synthase large ... 40 0.25
gi|23013681|ref|ZP_00053549.1| COG0458: Carbamoylphosphate synth... 40 0.25
gi|22095491|sp|P58942|CARB_XANAC Carbamoyl-phosphate synthase la... 40 0.25
gi|33322587|gb|AAQ07025.1| phosphoribosylaminoimidazolecarboxami... 40 0.25
gi|48846164|ref|ZP_00300430.1| COG0458: Carbamoylphosphate synth... 40 0.25
gi|41689213|ref|ZP_00145747.1| COG0458: Carbamoylphosphate synth... 39 0.32
gi|39996378|ref|NP_952329.1| carbamoyl-phosphate synthase, large... 39 0.32
gi|48848181|ref|ZP_00302427.1| COG0458: Carbamoylphosphate synth... 39 0.42
gi|50309841|ref|XP_454934.1| unnamed protein product [Kluyveromy... 39 0.55
gi|15643323|ref|NP_228367.1| carbamoyl-phosphate synthase, large... 38 0.72
gi|49069864|ref|XP_399221.1| hypothetical protein UM01606.1 [Ust... 38 0.94
gi|23113682|ref|ZP_00099038.1| COG0458: Carbamoylphosphate synth... 37 1.6
gi|22971060|ref|ZP_00018058.1| hypothetical protein [Chloroflexu... 37 1.6
gi|48477971|ref|YP_023677.1| carbamoyl-phosphate synthase [Picro... 36 2.7
gi|29374808|ref|NP_813960.1| conjugal transfer protein, putative... 36 2.7
gi|18311554|ref|NP_563488.1| carbamoyl-phosphate synthetase cata... 36 2.7
gi|15603370|ref|NP_246444.1| CarB [Pasteurella multocida Pm70] >... 36 2.7
gi|28829377|gb|AAO51917.1| hypothetical protein [Dictyostelium d... 36 3.6
gi|41723686|ref|ZP_00150596.1| COG0458: Carbamoylphosphate synth... 36 3.6
gi|27467797|ref|NP_764434.1| carbamoyl-phosphate synthase large ... 36 3.6
gi|15679751|ref|NP_276869.1| collagenase [Methanothermobacter th... 35 4.7
gi|15791854|ref|NP_281677.1| aldehyde dehydrogenase C-terminus [... 35 6.1
gi|39401|emb|CAA31623.1| unnamed protein product [Brevibacillus ... 35 6.1
gi|27467798|ref|NP_764435.1| orotidine-5-phosphate decarboxylase... 35 8.0
gi|50420269|ref|XP_458667.1| unnamed protein product [Debaryomyc... 35 8.0
>gi|25145659|ref|NP_741452.1| IMP cyclohydrolase (67.4 kD) (4I663)
[Caenorhabditis elegans]
gi|22532967|gb|AAL27234.2| Hypothetical protein C55F2.1b
[Caenorhabditis elegans]
Length = 615
Score = 1207 bits (3123), Expect = 0.0
Identities = 603/615 (98%), Positives = 603/615 (98%)
Frame = +1
Query: 1 MLEIEFYKTIDLIQYIDELCEMTDGKSLAIISVSDKTGLIPLAHGLVSAGLTLIASGGTA 180
MLEIEFYKTIDLIQYIDELCEMTDGKSLAIISVSDKTGLIPLAHGLVSAGLTLIASGGTA
Sbjct: 1 MLEIEFYKTIDLIQYIDELCEMTDGKSLAIISVSDKTGLIPLAHGLVSAGLTLIASGGTA 60
Query: 181 KAIRDQGIDVHDVADVTKFPEMLGGRVKTLHPAVHGGILARDTESDRKDLEKHNISFVSV 360
KAIRDQGIDVHDVADVTKFPEMLGGRVKTLHPAVHGGILARDTESDRKDLEKHNISFVSV
Sbjct: 61 KAIRDQGIDVHDVADVTKFPEMLGGRVKTLHPAVHGGILARDTESDRKDLEKHNISFVSV 120
Query: 361 VVCNLYPFKKTVQSKDCSVEEAVENIDIGGVTLLRAAAKNHERVSVICDPADYDHIISEL 540
VVCNLYPFKKTVQSKDCSVEEAVENIDIGGVTLLRAAAKNHERVSVICDPADYDHIISEL
Sbjct: 121 VVCNLYPFKKTVQSKDCSVEEAVENIDIGGVTLLRAAAKNHERVSVICDPADYDHIISEL 180
Query: 541 KSGGTTRERRQLLALKAFEHTTSYDESISGFMRRRFAGNGERALPLRYGTNPHQKDDAEL 720
KSGGTTRERRQLLALKAFEHTTSYDESISGFMRRRFAGNGERALPLRYGTNPHQKDDAEL
Sbjct: 181 KSGGTTRERRQLLALKAFEHTTSYDESISGFMRRRFAGNGERALPLRYGTNPHQKDDAEL 240
Query: 721 YIVEDEMPIKVLNGSPGYINILDGLNGWQLVKELSDATKMPAAASFKHVSPAGAAVGLPL 900
YIVEDEMPIKVLNGSPGYINILDGLNGWQLVKELSDATKMPAAASFKHVSPAGAAVGLPL
Sbjct: 241 YIVEDEMPIKVLNGSPGYINILDGLNGWQLVKELSDATKMPAAASFKHVSPAGAAVGLPL 300
Query: 901 NETEAACCMVSDLPIDTKKPSLXXXXXXXXXXXXMSSFGDFIALSEKCDELTAKIINREV 1080
NETEAACCMVSDLPIDTKKPSL MSSFGDFIALSEKCDELTAKIINREV
Sbjct: 301 NETEAACCMVSDLPIDTKKPSLAAAYARARGADRMSSFGDFIALSEKCDELTAKIINREV 360
Query: 1081 SDGVVAPDFDPAALSLLAKKKNGNYCVLKINPNYLPSETEERTVFGLRLRQKRNNAVINA 1260
SDGVVAPDFDPAALSLLAKKKNGNYCVLKINPNYLPSETEERTVFGLRLRQKRNNAVINA
Sbjct: 361 SDGVVAPDFDPAALSLLAKKKNGNYCVLKINPNYLPSETEERTVFGLRLRQKRNNAVINA 420
Query: 1261 ETFNNVVGSANELNKQAIDDLIVATIALKYAQSNSVCFAHRGQVIGMGAGQQSRIHCTRL 1440
ETFNNVVGSANELNKQAIDDLIVATIALKYAQSNSVCFAHRGQVIGMGAGQQSRIHCTRL
Sbjct: 421 ETFNNVVGSANELNKQAIDDLIVATIALKYAQSNSVCFAHRGQVIGMGAGQQSRIHCTRL 480
Query: 1441 AGDKAMNWWLRQHPTVLSLPWKNAIKRSEKSNAIDVLCSGVLGSEIAIDQWQQYFNEPVE 1620
AGDKAMNWWLRQHPTVLSLPWKNAIKRSEKSNAIDVLCSGVLGSEIAIDQWQQYFNEPVE
Sbjct: 481 AGDKAMNWWLRQHPTVLSLPWKNAIKRSEKSNAIDVLCSGVLGSEIAIDQWQQYFNEPVE 540
Query: 1621 PLAEDDRKQWLSQQTGVVMSSDAFLPFRDNVDCAKQFGVSYVAHPGGSVRDDDIKEACDE 1800
PLAEDDRKQWLSQQTGVVMSSDAFLPFRDNVDCAKQFGVSYVAHPGGSVRDDDIKEACDE
Sbjct: 541 PLAEDDRKQWLSQQTGVVMSSDAFLPFRDNVDCAKQFGVSYVAHPGGSVRDDDIKEACDE 600
Query: 1801 HGITLIHTGLRLFHH 1845
HGITLIHTGLRLFHH
Sbjct: 601 HGITLIHTGLRLFHH 615
>gi|25145656|ref|NP_741451.1| IMP cyclohydrolase (4I663)
[Caenorhabditis elegans]
Length = 666
Score = 1179 bits (3050), Expect = 0.0
Identities = 603/666 (90%), Positives = 603/666 (90%), Gaps = 51/666 (7%)
Frame = +1
Query: 1 MLEIEFYKTIDLIQYIDELCEMTDGKSLAIISVSDKTGLIPLAHGLVSAGLTLIASGGTA 180
MLEIEFYKTIDLIQYIDELCEMTDGKSLAIISVSDKTGLIPLAHGLVSAGLTLIASGGTA
Sbjct: 1 MLEIEFYKTIDLIQYIDELCEMTDGKSLAIISVSDKTGLIPLAHGLVSAGLTLIASGGTA 60
Query: 181 KAIRDQGIDVHDVADVTKFPEMLGGRVKTLHPAVHGGILARDTESDRKDLEKHNISFVSV 360
KAIRDQGIDVHDVADVTKFPEMLGGRVKTLHPAVHGGILARDTESDRKDLEKHNISFVSV
Sbjct: 61 KAIRDQGIDVHDVADVTKFPEMLGGRVKTLHPAVHGGILARDTESDRKDLEKHNISFVSV 120
Query: 361 VVCNLYPFKKTVQSKDCSVEEAVENIDIGGVTLLRAAAKNHERVSVICDPADYDHIISEL 540
VVCNLYPFKKTVQSKDCSVEEAVENIDIGGVTLLRAAAKNHERVSVICDPADYDHIISEL
Sbjct: 121 VVCNLYPFKKTVQSKDCSVEEAVENIDIGGVTLLRAAAKNHERVSVICDPADYDHIISEL 180
Query: 541 KSGGTTRERRQLLALKAFEHTTSYDESISGFMRRRFAGNGERALPLRYGTNPHQKDDAEL 720
KSGGTTRERRQLLALKAFEHTTSYDESISGFMRRRFAGNGERALPLRYGTNPHQKDDAEL
Sbjct: 181 KSGGTTRERRQLLALKAFEHTTSYDESISGFMRRRFAGNGERALPLRYGTNPHQKDDAEL 240
Query: 721 YIVEDEMPIKVLNGSPGYINILDGLNGWQLVKELSDATKMPAAASFKHVSPAGAAVGLPL 900
YIVEDEMPIKVLNGSPGYINILDGLNGWQLVKELSDATKMPAAASFKHVSPAGAAVGLPL
Sbjct: 241 YIVEDEMPIKVLNGSPGYINILDGLNGWQLVKELSDATKMPAAASFKHVSPAGAAVGLPL 300
Query: 901 NETEAACCMVSDLPIDTKKPSLXXXXXX-----------------XXXXXXMSSFGDFIA 1029
NETEAACCMVSDLPIDTKKPSL MSSFGDFIA
Sbjct: 301 NETEAACCMVSDLPIDTKKPSLAAAYARAREQDWMIADRLQRIAPSIGADRMSSFGDFIA 360
Query: 1030 LSEKCDELTAKIINREVSDGVVAPDFDPAALSLLAKKKNGNYCVLKINPNYLPSETEERT 1209
LSEKCDELTAKIINREVSDGVVAPDFDPAALSLLAKKKNGNYCVLKINPNYLPSETEERT
Sbjct: 361 LSEKCDELTAKIINREVSDGVVAPDFDPAALSLLAKKKNGNYCVLKINPNYLPSETEERT 420
Query: 1210 VFGLRLRQKRNNAVINAETFNNVVGSANE------------------------------- 1296
VFGLRLRQKRNNAVINAETFNNVVGSANE
Sbjct: 421 VFGLRLRQKRNNAVINAETFNNVVGSANEVSDIRSLQIFKKHFMLSFLQNFHKYNCIKKS 480
Query: 1297 ---LNKQAIDDLIVATIALKYAQSNSVCFAHRGQVIGMGAGQQSRIHCTRLAGDKAMNWW 1467
LNKQAIDDLIVATIALKYAQSNSVCFAHRGQVIGMGAGQQSRIHCTRLAGDKAMNWW
Sbjct: 481 LFQLNKQAIDDLIVATIALKYAQSNSVCFAHRGQVIGMGAGQQSRIHCTRLAGDKAMNWW 540
Query: 1468 LRQHPTVLSLPWKNAIKRSEKSNAIDVLCSGVLGSEIAIDQWQQYFNEPVEPLAEDDRKQ 1647
LRQHPTVLSLPWKNAIKRSEKSNAIDVLCSGVLGSEIAIDQWQQYFNEPVEPLAEDDRKQ
Sbjct: 541 LRQHPTVLSLPWKNAIKRSEKSNAIDVLCSGVLGSEIAIDQWQQYFNEPVEPLAEDDRKQ 600
Query: 1648 WLSQQTGVVMSSDAFLPFRDNVDCAKQFGVSYVAHPGGSVRDDDIKEACDEHGITLIHTG 1827
WLSQQTGVVMSSDAFLPFRDNVDCAKQFGVSYVAHPGGSVRDDDIKEACDEHGITLIHTG
Sbjct: 601 WLSQQTGVVMSSDAFLPFRDNVDCAKQFGVSYVAHPGGSVRDDDIKEACDEHGITLIHTG 660
Query: 1828 LRLFHH 1845
LRLFHH
Sbjct: 661 LRLFHH 666
>gi|39595034|emb|CAE70902.1| Hypothetical protein CBG17698
[Caenorhabditis briggsae]
Length = 648
Score = 1130 bits (2924), Expect = 0.0
Identities = 568/648 (87%), Positives = 589/648 (90%), Gaps = 33/648 (5%)
Frame = +1
Query: 1 MLEIEFYKTIDLIQYIDELCEMTDGKSLAIISVSDKTGLIPLAHGLVSAGLTLIASGGTA 180
M IEFYKTI LIQYIDELCEMTDGK+LAIISVSDKTGL+PLA GLVSAGL L+ASGGTA
Sbjct: 1 MWHIEFYKTIHLIQYIDELCEMTDGKTLAIISVSDKTGLLPLAEGLVSAGLVLVASGGTA 60
Query: 181 KAIRDQGIDVHDVADVTKFPEMLGGRVKTLHPAVHGGILARDTESDRKDLEKHNISFVSV 360
KAIRD GI+VHDVAD+TKFPEMLGGRVKTLHPAVHGGILARD+ESDRKDLE HNISFVS+
Sbjct: 61 KAIRDHGINVHDVADITKFPEMLGGRVKTLHPAVHGGILARDSESDRKDLETHNISFVSI 120
Query: 361 VVCNLYPFKKTVQSKDCSVEEAVENIDIGGVTLLRAAAKNHERVSVICDPADYDHIISEL 540
VVCNLYPFKKTVQ +CSVEEAVENIDIGGVTLLRAAAKNHERVSVICDPADYD+I+SEL
Sbjct: 121 VVCNLYPFKKTVQQSNCSVEEAVENIDIGGVTLLRAAAKNHERVSVICDPADYDNILSEL 180
Query: 541 KSGGTTRERRQLLALKAFEHTTSYDESISGFMRRRFAGNGERALPLRYGTNPHQKDDAEL 720
KSGGTTRERRQLLALKAFEHTTSYDESISGFMRRRFAGNGERALPLRYGTNPHQKDDAEL
Sbjct: 181 KSGGTTRERRQLLALKAFEHTTSYDESISGFMRRRFAGNGERALPLRYGTNPHQKDDAEL 240
Query: 721 YIVEDEMPIKVLNGSPGYINILDGLNGWQLVKELSDATKMPAAASFKHVSPAGAAVGLPL 900
YIVEDEMPIKVLNGSPGYINILDGLNGWQLVKELSDATKMPAAASFKHVSPAGAA+GLPL
Sbjct: 241 YIVEDEMPIKVLNGSPGYINILDGLNGWQLVKELSDATKMPAAASFKHVSPAGAAIGLPL 300
Query: 901 NETEAACCMVSDLPIDTKKPSLXXXXXX-----------------XXXXXXMSSFGDFIA 1029
NETE+ACCMVSDLPID KK SL MSSFGDFIA
Sbjct: 301 NETESACCMVSDLPIDPKKASLAAAYARAREQDWIINDRLQRFAPSVGADRMSSFGDFIA 360
Query: 1030 LSEKCDELTAKIINREVSDGVVAPDFDPAALSLLAKKKNGNYCVLKINPNYLPSETEERT 1209
LSEKCDELTAKIINREVSDGVVAPD+DPAALSLLAKKKNGNYCVLKINPNYLPSETEERT
Sbjct: 361 LSEKCDELTAKIINREVSDGVVAPDYDPAALSLLAKKKNGNYCVLKINPNYLPSETEERT 420
Query: 1210 VFGLRLRQKRNNAVINAETFNNVVGSAN----------------ELNKQAIDDLIVATIA 1341
VFGLRLRQKRNNAVINAETF NVVG N +LNKQAIDDLIVATIA
Sbjct: 421 VFGLRLRQKRNNAVINAETFTNVVGKENSEIREIETQISRIKCFQLNKQAIDDLIVATIA 480
Query: 1342 LKYAQSNSVCFAHRGQVIGMGAGQQSRIHCTRLAGDKAMNWWLRQHPTVLSLPWKNAIKR 1521
LKYAQSNSVCFAHRGQVIGMGAGQQSRIHCTRLAGDKA+NWWLRQHPTVLSLPWKNAIKR
Sbjct: 481 LKYAQSNSVCFAHRGQVIGMGAGQQSRIHCTRLAGDKAVNWWLRQHPTVLSLPWKNAIKR 540
Query: 1522 SEKSNAIDVLCSGVLGSEIAIDQWQQYFNEPVEPLAEDDRKQWLSQQTGVVMSSDAFLPF 1701
SEKSNAIDV+CSGVLGSEIA+DQWQQYFNEPVEPLAE++RKQWLSQQTGVVMSSDAFLPF
Sbjct: 541 SEKSNAIDVMCSGVLGSEIAVDQWQQYFNEPVEPLAEEERKQWLSQQTGVVMSSDAFLPF 600
Query: 1702 RDNVDCAKQFGVSYVAHPGGSVRDDDIKEACDEHGITLIHTGLRLFHH 1845
RDNVDCAKQFGVSYVAHPGGSVRD++IKEACDEHGITLIHTGLRLFHH
Sbjct: 601 RDNVDCAKQFGVSYVAHPGGSVRDEEIKEACDEHGITLIHTGLRLFHH 648
>gi|29570507|gb|AAL27233.2| Hypothetical protein C55F2.1a
[Caenorhabditis elegans]
Length = 420
Score = 694 bits (1792), Expect = 0.0
Identities = 357/420 (85%), Positives = 357/420 (85%), Gaps = 51/420 (12%)
Frame = +1
Query: 739 MPIKVLNGSPGYINILDGLNGWQLVKELSDATKMPAAASFKHVSPAGAAVGLPLNETEAA 918
MPIKVLNGSPGYINILDGLNGWQLVKELSDATKMPAAASFKHVSPAGAAVGLPLNETEAA
Sbjct: 1 MPIKVLNGSPGYINILDGLNGWQLVKELSDATKMPAAASFKHVSPAGAAVGLPLNETEAA 60
Query: 919 CCMVSDLPIDTKKPSLXXXXXXXXX-----------------XXXMSSFGDFIALSEKCD 1047
CCMVSDLPIDTKKPSL MSSFGDFIALSEKCD
Sbjct: 61 CCMVSDLPIDTKKPSLAAAYARAREQDWMIADRLQRIAPSIGADRMSSFGDFIALSEKCD 120
Query: 1048 ELTAKIINREVSDGVVAPDFDPAALSLLAKKKNGNYCVLKINPNYLPSETEERTVFGLRL 1227
ELTAKIINREVSDGVVAPDFDPAALSLLAKKKNGNYCVLKINPNYLPSETEERTVFGLRL
Sbjct: 121 ELTAKIINREVSDGVVAPDFDPAALSLLAKKKNGNYCVLKINPNYLPSETEERTVFGLRL 180
Query: 1228 RQKRNNAVINAETFNNVVGSANE----------------------------------LNK 1305
RQKRNNAVINAETFNNVVGSANE LNK
Sbjct: 181 RQKRNNAVINAETFNNVVGSANEVSDIRSLQIFKKHFMLSFLQNFHKYNCIKKSLFQLNK 240
Query: 1306 QAIDDLIVATIALKYAQSNSVCFAHRGQVIGMGAGQQSRIHCTRLAGDKAMNWWLRQHPT 1485
QAIDDLIVATIALKYAQSNSVCFAHRGQVIGMGAGQQSRIHCTRLAGDKAMNWWLRQHPT
Sbjct: 241 QAIDDLIVATIALKYAQSNSVCFAHRGQVIGMGAGQQSRIHCTRLAGDKAMNWWLRQHPT 300
Query: 1486 VLSLPWKNAIKRSEKSNAIDVLCSGVLGSEIAIDQWQQYFNEPVEPLAEDDRKQWLSQQT 1665
VLSLPWKNAIKRSEKSNAIDVLCSGVLGSEIAIDQWQQYFNEPVEPLAEDDRKQWLSQQT
Sbjct: 301 VLSLPWKNAIKRSEKSNAIDVLCSGVLGSEIAIDQWQQYFNEPVEPLAEDDRKQWLSQQT 360
Query: 1666 GVVMSSDAFLPFRDNVDCAKQFGVSYVAHPGGSVRDDDIKEACDEHGITLIHTGLRLFHH 1845
GVVMSSDAFLPFRDNVDCAKQFGVSYVAHPGGSVRDDDIKEACDEHGITLIHTGLRLFHH
Sbjct: 361 GVVMSSDAFLPFRDNVDCAKQFGVSYVAHPGGSVRDDDIKEACDEHGITLIHTGLRLFHH 420
>gi|24649832|ref|NP_651305.1| CG11089-PA [Drosophila melanogaster]
gi|7301227|gb|AAF56358.1| CG11089-PA [Drosophila melanogaster]
gi|41058144|gb|AAR99120.1| RE29555p [Drosophila melanogaster]
Length = 590
Score = 683 bits (1762), Expect = 0.0
Identities = 337/589 (57%), Positives = 431/589 (72%), Gaps = 1/589 (0%)
Frame = +1
Query: 82 LAIISVSDKTGLIPLAHGLVSAGLTLIASGGTAKAIRDQGIDVHDVADVTKFPEMLGGRV 261
+A++SVSDKTGL+ L LV+ G L+ASGGTA ++R G+ V DV+++T PEMLGGRV
Sbjct: 6 IALLSVSDKTGLLDLGKSLVALGFDLVASGGTATSLRGAGLKVRDVSEITGAPEMLGGRV 65
Query: 262 KTLHPAVHGGILARDTESDRKDLEKHNISFVSVVVCNLYPFKKTVQSKDCSVEEAVENID 441
KTLHPAVH GIL+R T+SD D+ K + +VVCNLYPF TV D ++ +AVENID
Sbjct: 66 KTLHPAVHAGILSRTTDSDLADMRKQGFDLIQLVVCNLYPFASTVAKPDVTLADAVENID 125
Query: 442 IGGVTLLRAAAKNHERVSVICDPADYDHIISELK-SGGTTRERRQLLALKAFEHTTSYDE 618
IGGVTLLRAAAKNH+RV+V+C+ DYD ++SELK SG TT E RQ LALKAF HT +YD+
Sbjct: 126 IGGVTLLRAAAKNHQRVTVVCEAVDYDRVLSELKASGNTTVETRQALALKAFTHTATYDD 185
Query: 619 SISGFMRRRFAGNGERALPLRYGTNPHQKDDAELYIVEDEMPIKVLNGSPGYINILDGLN 798
+IS + R+++ G+G LPLRYG NPHQK A+LY ++P+ VLN SPG+IN+ D LN
Sbjct: 186 AISDYFRKQY-GSGVSQLPLRYGMNPHQKP-AQLYTQLAKLPLTVLNASPGFINLCDALN 243
Query: 799 GWQLVKELSDATKMPAAASFKHVSPAGAAVGLPLNETEAACCMVSDLPIDTKKPSLXXXX 978
GWQLV+EL A ++PAA SFKHVSPAGAAVG+PLN +A CMV DL + L
Sbjct: 244 GWQLVRELKKALQLPAATSFKHVSPAGAAVGVPLNPAQAKLCMVDDLY--EQLTPLATAY 301
Query: 979 XXXXXXXXMSSFGDFIALSEKCDELTAKIINREVSDGVVAPDFDPAALSLLAKKKNGNYC 1158
MSSFGDF+ALS+ CD +TA+II+REVSDG++A ++P AL +L KKKNG YC
Sbjct: 302 ARARGADRMSSFGDFVALSDVCDVVTARIISREVSDGIIAAGYEPEALEILKKKKNGGYC 361
Query: 1159 VLKINPNYLPSETEERTVFGLRLRQKRNNAVINAETFNNVVGSANELNKQAIDDLIVATI 1338
+L+++PNY PS E +T+FGL L QKRN+AVI+A F+NVV L + A+ DLIVATI
Sbjct: 362 ILQMDPNYEPSAVERKTIFGLTLEQKRNDAVIDASLFSNVVSKRGPLPEVAVRDLIVATI 421
Query: 1339 ALKYAQSNSVCFAHRGQVIGMGAGQQSRIHCTRLAGDKAMNWWLRQHPTVLSLPWKNAIK 1518
ALKY QSNSVC+A GQV+G+GAGQQSRIHCTRLAG+KA NWWLRQHP+V + +K +K
Sbjct: 422 ALKYTQSNSVCYARDGQVVGIGAGQQSRIHCTRLAGEKADNWWLRQHPSVAGMKFKAGVK 481
Query: 1519 RSEKSNAIDVLCSGVLGSEIAIDQWQQYFNEPVEPLAEDDRKQWLSQQTGVVMSSDAFLP 1698
R+E SNAID +G +G ++ + Q++ F++ L + + +WL Q +GV + SDAF P
Sbjct: 482 RAEISNAIDNYVNGTVGKDMPLSQFEGMFDKAPAQLTSEQKVEWLKQLSGVALGSDAFFP 541
Query: 1699 FRDNVDCAKQFGVSYVAHPGGSVRDDDIKEACDEHGITLIHTGLRLFHH 1845
FRDN+D A GVSY+A P GS D + ACDEHGI + HT LRLFHH
Sbjct: 542 FRDNIDRASLSGVSYIASPAGSTNDAGVIAACDEHGIIMAHTNLRLFHH 590
>gi|49250888|gb|AAH74584.1| Unknown (protein for MGC:69458) [Xenopus
tropicalis]
Length = 589
Score = 680 bits (1754), Expect = 0.0
Identities = 348/591 (58%), Positives = 435/591 (72%), Gaps = 3/591 (0%)
Frame = +1
Query: 82 LAIISVSDKTGLIPLAHGLVSAGLTLIASGGTAKAIRDQGIDVHDVADVTKFPEMLGGRV 261
+A+ SVSDKTGL+ A L + GL+L+ASGGTAK +RD G+ V DV+++T FPEMLGGRV
Sbjct: 4 IALFSVSDKTGLVEFAQQLSTLGLSLVASGGTAKCLRDAGLSVRDVSEITGFPEMLGGRV 63
Query: 262 KTLHPAVHGGILARDTESDRKDLEKHNISFVSVVVCNLYPFKKTVQSKDCSVEEAVENID 441
KTLHPAVH GILAR + D+ DL K S+V VVVCNLYPF KTV + +VEEAVE ID
Sbjct: 64 KTLHPAVHAGILARSSPEDQADLNKLGFSYVRVVVCNLYPFVKTVSAAGVTVEEAVEQID 123
Query: 442 IGGVTLLRAAAKNHERVSVICDPADYDHIISELKSGG---TTRERRQLLALKAFEHTTSY 612
IGGVTLLRAAAKNH RV+V+CDP+DY I E+ TT ERR LALKAF HT Y
Sbjct: 124 IGGVTLLRAAAKNHARVTVLCDPSDYKSIAEEMGKSDKKDTTPERRCQLALKAFTHTAQY 183
Query: 613 DESISGFMRRRFAGNGERALPLRYGTNPHQKDDAELYIVEDEMPIKVLNGSPGYINILDG 792
D++IS + R++++ G LPLRYG NPHQ A++Y ++P+ VLNGSPG+IN+ D
Sbjct: 184 DDAISDYFRKQYS-KGTSQLPLRYGINPHQVP-AQIYTRGPQLPLTVLNGSPGFINLCDA 241
Query: 793 LNGWQLVKELSDATKMPAAASFKHVSPAGAAVGLPLNETEAACCMVSDLPIDTKKPSLXX 972
LN WQLV+EL +A +PAA SFKHVSPAGAAVG+PL E EA CMV DL T P L
Sbjct: 242 LNAWQLVRELKNALGLPAATSFKHVSPAGAAVGVPLMEEEAQVCMVQDL-FPTLTP-LAT 299
Query: 973 XXXXXXXXXXMSSFGDFIALSEKCDELTAKIINREVSDGVVAPDFDPAALSLLAKKKNGN 1152
MSSFGDFIA+S+ CD TAKII+REVSDG+VAP ++ AL +L+KKKNG+
Sbjct: 300 AYARARGADRMSSFGDFIAVSDVCDVATAKIISREVSDGIVAPGYEDEALKILSKKKNGS 359
Query: 1153 YCVLKINPNYLPSETEERTVFGLRLRQKRNNAVINAETFNNVVGSANELNKQAIDDLIVA 1332
YCVL+++P+Y PS+ E R++FGL+L QKRN+AVI+ +NNVV + E+ + A+ DLIVA
Sbjct: 360 YCVLQMDPSYEPSDIEIRSIFGLQLEQKRNDAVIDRNLYNNVVTNNKEIPESAVRDLIVA 419
Query: 1333 TIALKYAQSNSVCFAHRGQVIGMGAGQQSRIHCTRLAGDKAMNWWLRQHPTVLSLPWKNA 1512
TIALKY QSNSVC+A GQVIGMGAGQQSRIHCTRLAGDKA NWWLR HP VL + +K
Sbjct: 420 TIALKYTQSNSVCYAKDGQVIGMGAGQQSRIHCTRLAGDKADNWWLRHHPRVLGMKFKAG 479
Query: 1513 IKRSEKSNAIDVLCSGVLGSEIAIDQWQQYFNEPVEPLAEDDRKQWLSQQTGVVMSSDAF 1692
+KR++ SNAID SG LG E + QWQ +++P E L ++K W+S+ +GV +SSDAF
Sbjct: 480 VKRADISNAIDQYVSGTLGEE-DLPQWQALYDQPPEQLTLAEKKDWISKLSGVALSSDAF 538
Query: 1693 LPFRDNVDCAKQFGVSYVAHPGGSVRDDDIKEACDEHGITLIHTGLRLFHH 1845
PF+DN++ AK+ GV ++A P GS D + +AC+E GI L HT LRLFHH
Sbjct: 539 FPFKDNLERAKKSGVQFIAAPSGSSADKIVIDACNELGIVLAHTNLRLFHH 589
>gi|28373618|pdb|1M9N|A Chain A, Crystal Structure Of The Homodimeric
Bifunctional Transformylase And Cyclohydrolase Enzyme
Avian Atic In Complex With Aicar And Xmp At 1.93
Angstroms.
gi|28373619|pdb|1M9N|B Chain B, Crystal Structure Of The Homodimeric
Bifunctional Transformylase And Cyclohydrolase Enzyme
Avian Atic In Complex With Aicar And Xmp At 1.93
Angstroms.
gi|37927353|pdb|1OZ0|A Chain A, Crystal Structure Of The Homodimeric
Bifunctional Transformylase And Cyclohydrolase Enzyme
Avian Atic In Complex With A Multisubstrate Adduct
Inhibitor Beta-Dadf.
gi|37927354|pdb|1OZ0|B Chain B, Crystal Structure Of The Homodimeric
Bifunctional Transformylase And Cyclohydrolase Enzyme
Avian Atic In Complex With A Multisubstrate Adduct
Inhibitor Beta-Dadf
Length = 613
Score = 679 bits (1751), Expect = 0.0
Identities = 351/597 (58%), Positives = 429/597 (71%), Gaps = 3/597 (0%)
Frame = +1
Query: 64 MTDGKSLAIISVSDKTGLIPLAHGLVSAGLTLIASGGTAKAIRDQGIDVHDVADVTKFPE 243
M + LA++SVS+K GL+ A L + GL LIASGGTA A+RD G+ V DV+D+T FPE
Sbjct: 21 MAARQQLALLSVSEKAGLVEFARSLNALGLGLIASGGTATALRDAGLPVRDVSDLTGFPE 80
Query: 244 MLGGRVKTLHPAVHGGILARDTESDRKDLEKHNISFVSVVVCNLYPFKKTVQSKDCSVEE 423
MLGGRVKTLHPAVH GILAR+ D D+ K + S V VVVCNLYPF KTV S +V E
Sbjct: 81 MLGGRVKTLHPAVHAGILARNIPEDNADMNKQDFSLVRVVVCNLYPFVKTVSSPGVTVPE 140
Query: 424 AVENIDIGGVTLLRAAAKNHERVSVICDPADYDHIISEL---KSGGTTRERRQLLALKAF 594
AVE IDIGGV LLRAAAKNH RV+V+CDPADY + E+ K T+ E R+ LALKAF
Sbjct: 141 AVEKIDIGGVALLRAAAKNHARVTVVCDPADYSSVAKEMAASKDKDTSVETRRHLALKAF 200
Query: 595 EHTTSYDESISGFMRRRFAGNGERALPLRYGTNPHQKDDAELYIVEDEMPIKVLNGSPGY 774
HT YD +IS + R+ ++ G LPLRYG NPHQ A+LY ++P+ V+NGSPG+
Sbjct: 201 THTAQYDAAISDYFRKEYS-KGVSQLPLRYGMNPHQSP-AQLYTTRPKLPLTVVNGSPGF 258
Query: 775 INILDGLNGWQLVKELSDATKMPAAASFKHVSPAGAAVGLPLNETEAACCMVSDLPIDTK 954
IN+ D LN WQLVKEL A +PAAASFKHVSPAGAAVG+PL+E EA CMV DL T
Sbjct: 259 INLCDALNAWQLVKELKQALGIPAAASFKHVSPAGAAVGIPLSEEEAQVCMVHDLH-KTL 317
Query: 955 KPSLXXXXXXXXXXXXMSSFGDFIALSEKCDELTAKIINREVSDGVVAPDFDPAALSLLA 1134
P L MSSFGDFIALS+ CD TAKII+REVSDGVVAP ++ AL +L+
Sbjct: 318 TP-LASAYARSRGADRMSSFGDFIALSDICDVPTAKIISREVSDGVVAPGYEEEALKILS 376
Query: 1135 KKKNGNYCVLKINPNYLPSETEERTVFGLRLRQKRNNAVINAETFNNVVGSANELNKQAI 1314
KKKNG YCVL+++PNY P + E RT++GL+L QKRNNAVI+ F N+V L + A+
Sbjct: 377 KKKNGGYCVLQMDPNYEPDDNEIRTLYGLQLMQKRNNAVIDRSLFKNIVTKNKTLPESAV 436
Query: 1315 DDLIVATIALKYAQSNSVCFAHRGQVIGMGAGQQSRIHCTRLAGDKAMNWWLRQHPTVLS 1494
DLIVA+IA+KY QSNSVC+A GQVIG+GAGQQSRIHCTRLAGDKA +WWLR HP VLS
Sbjct: 437 RDLIVASIAVKYTQSNSVCYAKDGQVIGIGAGQQSRIHCTRLAGDKANSWWLRHHPRVLS 496
Query: 1495 LPWKNAIKRSEKSNAIDVLCSGVLGSEIAIDQWQQYFNEPVEPLAEDDRKQWLSQQTGVV 1674
+ +K +KR+E SNAID +G +G + + +WQ F E L E ++KQW+++ T V
Sbjct: 497 MKFKAGVKRAEVSNAIDQYVTGTIGEDEDLVKWQAMFEEVPAQLTEAEKKQWIAKLTAVS 556
Query: 1675 MSSDAFLPFRDNVDCAKQFGVSYVAHPGGSVRDDDIKEACDEHGITLIHTGLRLFHH 1845
+SSDAF PFRDNVD AK+ GV ++ P GS D+ + EAC+E GITLIHT LRLFHH
Sbjct: 557 LSSDAFFPFRDNVDRAKRIGVQFIVAPSGSAADEVVIEACNELGITLIHTNLRLFHH 613
>gi|45384004|ref|NP_990509.1|
5-aminoimidazole-4-carboxamide-ribonucleotide
transformylase-IMP cyclohydrolase;
5-aminoimidazole-4-carboxamide-ribonucleotide
transformylase-IMP cyclohydrolase, ATIC [Gallus gallus]
gi|400901|sp|P31335|PUR9_CHICK Bifunctional purine biosynthesis
protein PURH [Includes:
Phosphoribosylaminoimidazolecarboxamide formyltransferase
(AICAR transformylase); IMP cyclohydrolase (Inosinicase)
(IMP synthetase) (ATIC)]
gi|279480|pir||DTCHPH purH bifunctional enzyme - chicken
gi|238786|gb|AAB20309.1|
5-aminoimidazole-4-carboxamide-ribonucleotide
transformylase-IMP cyclohydrolase; ATIC [Gallus gallus]
Length = 593
Score = 679 bits (1751), Expect = 0.0
Identities = 351/597 (58%), Positives = 429/597 (71%), Gaps = 3/597 (0%)
Frame = +1
Query: 64 MTDGKSLAIISVSDKTGLIPLAHGLVSAGLTLIASGGTAKAIRDQGIDVHDVADVTKFPE 243
M + LA++SVS+K GL+ A L + GL LIASGGTA A+RD G+ V DV+D+T FPE
Sbjct: 1 MAARQQLALLSVSEKAGLVEFARSLNALGLGLIASGGTATALRDAGLPVRDVSDLTGFPE 60
Query: 244 MLGGRVKTLHPAVHGGILARDTESDRKDLEKHNISFVSVVVCNLYPFKKTVQSKDCSVEE 423
MLGGRVKTLHPAVH GILAR+ D D+ K + S V VVVCNLYPF KTV S +V E
Sbjct: 61 MLGGRVKTLHPAVHAGILARNIPEDNADMNKQDFSLVRVVVCNLYPFVKTVSSPGVTVPE 120
Query: 424 AVENIDIGGVTLLRAAAKNHERVSVICDPADYDHIISEL---KSGGTTRERRQLLALKAF 594
AVE IDIGGV LLRAAAKNH RV+V+CDPADY + E+ K T+ E R+ LALKAF
Sbjct: 121 AVEKIDIGGVALLRAAAKNHARVTVVCDPADYSSVAKEMAASKDKDTSVETRRHLALKAF 180
Query: 595 EHTTSYDESISGFMRRRFAGNGERALPLRYGTNPHQKDDAELYIVEDEMPIKVLNGSPGY 774
HT YD +IS + R+ ++ G LPLRYG NPHQ A+LY ++P+ V+NGSPG+
Sbjct: 181 THTAQYDAAISDYFRKEYS-KGVSQLPLRYGMNPHQSP-AQLYTTRPKLPLTVVNGSPGF 238
Query: 775 INILDGLNGWQLVKELSDATKMPAAASFKHVSPAGAAVGLPLNETEAACCMVSDLPIDTK 954
IN+ D LN WQLVKEL A +PAAASFKHVSPAGAAVG+PL+E EA CMV DL T
Sbjct: 239 INLCDALNAWQLVKELKQALGIPAAASFKHVSPAGAAVGIPLSEEEAQVCMVHDLH-KTL 297
Query: 955 KPSLXXXXXXXXXXXXMSSFGDFIALSEKCDELTAKIINREVSDGVVAPDFDPAALSLLA 1134
P L MSSFGDFIALS+ CD TAKII+REVSDGVVAP ++ AL +L+
Sbjct: 298 TP-LASAYARSRGADRMSSFGDFIALSDICDVPTAKIISREVSDGVVAPGYEEEALKILS 356
Query: 1135 KKKNGNYCVLKINPNYLPSETEERTVFGLRLRQKRNNAVINAETFNNVVGSANELNKQAI 1314
KKKNG YCVL+++PNY P + E RT++GL+L QKRNNAVI+ F N+V L + A+
Sbjct: 357 KKKNGGYCVLQMDPNYEPDDNEIRTLYGLQLMQKRNNAVIDRSLFKNIVTKNKTLPESAV 416
Query: 1315 DDLIVATIALKYAQSNSVCFAHRGQVIGMGAGQQSRIHCTRLAGDKAMNWWLRQHPTVLS 1494
DLIVA+IA+KY QSNSVC+A GQVIG+GAGQQSRIHCTRLAGDKA +WWLR HP VLS
Sbjct: 417 RDLIVASIAVKYTQSNSVCYAKDGQVIGIGAGQQSRIHCTRLAGDKANSWWLRHHPRVLS 476
Query: 1495 LPWKNAIKRSEKSNAIDVLCSGVLGSEIAIDQWQQYFNEPVEPLAEDDRKQWLSQQTGVV 1674
+ +K +KR+E SNAID +G +G + + +WQ F E L E ++KQW+++ T V
Sbjct: 477 MKFKAGVKRAEVSNAIDQYVTGTIGEDEDLVKWQAMFEEVPAQLTEAEKKQWIAKLTAVS 536
Query: 1675 MSSDAFLPFRDNVDCAKQFGVSYVAHPGGSVRDDDIKEACDEHGITLIHTGLRLFHH 1845
+SSDAF PFRDNVD AK+ GV ++ P GS D+ + EAC+E GITLIHT LRLFHH
Sbjct: 537 LSSDAFFPFRDNVDRAKRIGVQFIVAPSGSAADEVVIEACNELGITLIHTNLRLFHH 593
>gi|48675845|ref|NP_112276.2| 5-aminoimidazole-4-carboxamide
ribonucleotide formyltransferase/IMP cyclohydrolase
[Rattus norvegicus]
gi|47939008|gb|AAH72496.1| 5-aminoimidazole-4-carboxamide
ribonucleotide formyltransferase/ [Rattus norvegicus]
Length = 592
Score = 679 bits (1751), Expect = 0.0
Identities = 348/591 (58%), Positives = 434/591 (72%), Gaps = 3/591 (0%)
Frame = +1
Query: 82 LAIISVSDKTGLIPLAHGLVSAGLTLIASGGTAKAIRDQGIDVHDVADVTKFPEMLGGRV 261
LA+ SVSDKTGL+ A L S GL+L+ASGGTAKAIRD G+ V DV+++T FPEMLGGRV
Sbjct: 6 LALFSVSDKTGLVEFARNLASLGLSLVASGGTAKAIRDAGLAVRDVSELTGFPEMLGGRV 65
Query: 262 KTLHPAVHGGILARDTESDRKDLEKHNISFVSVVVCNLYPFKKTVQSKDCSVEEAVENID 441
KTLHPAVH GILAR+ D D+ + + + + VVVCNLYPF KTV S D +VE AVE ID
Sbjct: 66 KTLHPAVHAGILARNIPEDAADMARLDFNLIRVVVCNLYPFVKTVASPDVTVEAAVEQID 125
Query: 442 IGGVTLLRAAAKNHERVSVICDPADYDHIISELKSGG---TTRERRQLLALKAFEHTTSY 612
IGGVTLLRAAAKNH RV+V+C+P DY + +E++ G T+ E R+ LALKAF HT Y
Sbjct: 126 IGGVTLLRAAAKNHARVTVVCEPEDYGAVAAEMQGSGNKDTSLETRRHLALKAFTHTAQY 185
Query: 613 DESISGFMRRRFAGNGERALPLRYGTNPHQKDDAELYIVEDEMPIKVLNGSPGYINILDG 792
DE+IS + RR+++ G +PLRYG NPHQ A+LY ++ ++PI VLNG+PG+IN+ D
Sbjct: 186 DEAISDYFRRQYS-KGISQMPLRYGMNPHQTP-AQLYTLKPKLPITVLNGAPGFINLCDA 243
Query: 793 LNGWQLVKELSDATKMPAAASFKHVSPAGAAVGLPLNETEAACCMVSDLPIDTKKPSLXX 972
LN WQLV EL A +PAAASFKHVSPAGAAVG+PL+E EA CMV DL T P L
Sbjct: 244 LNAWQLVTELRGAVDIPAAASFKHVSPAGAAVGVPLSEDEARVCMVYDL-YPTLTP-LAI 301
Query: 973 XXXXXXXXXXMSSFGDFIALSEKCDELTAKIINREVSDGVVAPDFDPAALSLLAKKKNGN 1152
MSSFGDF+ALS+ CD TAKII+REVSDG+VAP ++ AL +L+KKKNG+
Sbjct: 302 AYARARGADRMSSFGDFVALSDVCDVPTAKIISREVSDGIVAPGYEEEALKILSKKKNGS 361
Query: 1153 YCVLKINPNYLPSETEERTVFGLRLRQKRNNAVINAETFNNVVGSANELNKQAIDDLIVA 1332
YCVL+++ +Y P E E RT+FGLRL QKRNN V++ F+N+V +L + A+ DLIVA
Sbjct: 362 YCVLQMDQSYKPDENEVRTLFGLRLSQKRNNGVVDKSLFSNIVTKNKDLPESALRDLIVA 421
Query: 1333 TIALKYAQSNSVCFAHRGQVIGMGAGQQSRIHCTRLAGDKAMNWWLRQHPTVLSLPWKNA 1512
TIA+KY QSNSVC+A GQVIG+GAGQQSRIHCTRLAGDKA +WWLR HP VLS+ +K
Sbjct: 422 TIAVKYTQSNSVCYAKDGQVIGIGAGQQSRIHCTRLAGDKANSWWLRHHPRVLSMKFKAG 481
Query: 1513 IKRSEKSNAIDVLCSGVLGSEIAIDQWQQYFNEPVEPLAEDDRKQWLSQQTGVVMSSDAF 1692
+KR+E SNAID +G +G + +W+ F E E L E ++K+W+ + +GV +SSDAF
Sbjct: 482 VKRAEVSNAIDQYVTGTIGEGEDLVKWKALFEEVPELLTEAEKKEWVDKLSGVSVSSDAF 541
Query: 1693 LPFRDNVDCAKQFGVSYVAHPGGSVRDDDIKEACDEHGITLIHTGLRLFHH 1845
PFRDNVD AK+ GV+Y+ P GS D + EACDE GI L HT LRLFHH
Sbjct: 542 FPFRDNVDRAKRSGVAYIVAPSGSTADKVVIEACDELGIVLAHTDLRLFHH 592
>gi|1263196|gb|AAA97405.1| AICAR formyltransferase/IMP cyclohydrolase
bifunctional enzyme
Length = 591
Score = 678 bits (1750), Expect = 0.0
Identities = 345/590 (58%), Positives = 434/590 (73%), Gaps = 3/590 (0%)
Frame = +1
Query: 85 AIISVSDKTGLIPLAHGLVSAGLTLIASGGTAKAIRDQGIDVHDVADVTKFPEMLGGRVK 264
A+ SVSDKTGL+ A L + GL L+ASGGTAKA+RD G+ V DV+++T FPEMLGGRVK
Sbjct: 6 ALFSVSDKTGLVEFARNLTALGLNLVASGGTAKALRDAGLAVRDVSELTGFPEMLGGRVK 65
Query: 265 TLHPAVHGGILARDTESDRKDLEKHNISFVSVVVCNLYPFKKTVQSKDCSVEEAVENIDI 444
TLHPAVH GILAR+ D D+ + + + + VV CNLYPF KTV S +VEEAVE IDI
Sbjct: 66 TLHPAVHAGILARNIPEDNADMARLDFNLIRVVACNLYPFVKTVASPGVTVEEAVEQIDI 125
Query: 445 GGVTLLRAAAKNHERVSVICDPADYDHIISELKSG---GTTRERRQLLALKAFEHTTSYD 615
GGVTLLRAAAKNH RV+V+C+P DY + +E++S GT+ E R+ LALKAF HT YD
Sbjct: 126 GGVTLLRAAAKNHARVTVVCEPEDYVVVSTEMQSSESKGTSLETRRQLALKAFTHTAQYD 185
Query: 616 ESISGFMRRRFAGNGERALPLRYGTNPHQKDDAELYIVEDEMPIKVLNGSPGYINILDGL 795
E+IS + R++++ G +PLRYG NPHQ A+LY ++ ++PI VLNG+PG+IN+ D L
Sbjct: 186 EAISDYFRKQYS-KGVSQMPLRYGMNPHQTP-AQLYTLQPKLPITVLNGAPGFINLCDAL 243
Query: 796 NGWQLVKELSDATKMPAAASFKHVSPAGAAVGLPLNETEAACCMVSDLPIDTKKPSLXXX 975
N WQLVKEL +A +PAAASFKHVSPAGAAVG+PL+E EA CMV DL T P +
Sbjct: 244 NAWQLVKELKEALGIPAAASFKHVSPAGAAVGIPLSEDEAKVCMVYDL-YKTLTP-ISAA 301
Query: 976 XXXXXXXXXMSSFGDFIALSEKCDELTAKIINREVSDGVVAPDFDPAALSLLAKKKNGNY 1155
MSSFGDF+ALS+ CD TAKII+REVSDG++AP ++ AL++L+KKKNGNY
Sbjct: 302 YARARGADRMSSFGDFVALSDVCDVPTAKIISREVSDGIIAPGYEEEALTILSKKKNGNY 361
Query: 1156 CVLKINPNYLPSETEERTVFGLRLRQKRNNAVINAETFNNVVGSANELNKQAIDDLIVAT 1335
CVL+++ +Y P E E RT+FGL L QKRNN V++ F+NVV +L + A+ DLIVAT
Sbjct: 362 CVLQMDQSYKPDENEVRTLFGLHLSQKRNNGVVDKSLFSNVVTKNKDLPESALRDLIVAT 421
Query: 1336 IALKYAQSNSVCFAHRGQVIGMGAGQQSRIHCTRLAGDKAMNWWLRQHPTVLSLPWKNAI 1515
IA+KY QSNSVC+A GQVIG+GAGQQSRIHCTRLAGDKA WWLR HP VLS+ +K +
Sbjct: 422 IAVKYTQSNSVCYAKNGQVIGIGAGQQSRIHCTRLAGDKANYWWLRHHPQVLSMKFKTGV 481
Query: 1516 KRSEKSNAIDVLCSGVLGSEIAIDQWQQYFNEPVEPLAEDDRKQWLSQQTGVVMSSDAFL 1695
KR+E SNAID +G +G + + +W+ F E E L E ++K+W+ + T V +SSDAF
Sbjct: 482 KRAEISNAIDQYVTGTIGEDEDLIKWKALFEEVPELLTEAEKKEWVEKLTEVSISSDAFF 541
Query: 1696 PFRDNVDCAKQFGVSYVAHPGGSVRDDDIKEACDEHGITLIHTGLRLFHH 1845
PFRDNVD AK+ GV+Y+A P GS D + EACDE GI L HT LRLFHH
Sbjct: 542 PFRDNVDRAKRSGVAYIAAPSGSAADKVVIEACDELGIILAHTNLRLFHH 591
>gi|20127454|ref|NP_004035.2| 5-aminoimidazole-4-carboxamide
ribonucleotide formyltransferase/IMP cyclohydrolase;
AICARFT/IMPCHASE [Homo sapiens]
gi|23831360|sp|P31939|PUR9_HUMAN Bifunctional purine biosynthesis
protein PURH [Includes:
Phosphoribosylaminoimidazolecarboxamide formyltransferase
(AICAR transformylase); IMP cyclohydrolase (Inosinicase)
(IMP synthetase) (ATIC)]
gi|2117697|pir||JC4642 purH bifunctional enzyme - human
gi|46015217|pdb|1PKX|A Chain A, Crystal Structure Of Human Atic In
Complex With Xmp
gi|46015218|pdb|1PKX|B Chain B, Crystal Structure Of Human Atic In
Complex With Xmp
gi|46015219|pdb|1PKX|C Chain C, Crystal Structure Of Human Atic In
Complex With Xmp
gi|46015220|pdb|1PKX|D Chain D, Crystal Structure Of Human Atic In
Complex With Xmp
gi|47168534|pdb|1P4R|A Chain A, Crystal Structure Of Human Atic In
Complex With Folate- Based Inhibitor Bw1540u88ud
gi|47168535|pdb|1P4R|B Chain B, Crystal Structure Of Human Atic In
Complex With Folate- Based Inhibitor Bw1540u88ud
gi|48425206|pdb|1PL0|A Chain A, Crystal Structure Of Human Atic In
Complex With Folate- Based Inhibitor, Bw2315u89uc
gi|48425207|pdb|1PL0|B Chain B, Crystal Structure Of Human Atic In
Complex With Folate- Based Inhibitor, Bw2315u89uc
gi|48425208|pdb|1PL0|C Chain C, Crystal Structure Of Human Atic In
Complex With Folate- Based Inhibitor, Bw2315u89uc
gi|48425209|pdb|1PL0|D Chain D, Crystal Structure Of Human Atic In
Complex With Folate- Based Inhibitor, Bw2315u89uc
gi|1311462|dbj|BAA11559.1|
5-aminoimidazole-4-carboxamide-1-beta-D-ribonucl eotide
transformylase/inosinicase [Homo sapiens]
gi|2317692|dbj|BAA21762.1| 5-aminoimidazole-4-carboxamide
ribonucleotide transformylase [Homo sapiens]
gi|14250818|gb|AAH08879.1| 5-aminoimidazole-4-carboxamide
ribonucleotide formyltransferase/IMP cyclohydrolase [Homo
sapiens]
gi|21104440|dbj|BAB93490.1|
5-aminoimidazole-4-carboxamide-1-bata-D-ribonucl eotid
transformylase/inosinicase [Homo sapiens]
gi|1588260|prf||2208275A purH gene
Length = 592
Score = 677 bits (1747), Expect = 0.0
Identities = 345/591 (58%), Positives = 434/591 (73%), Gaps = 3/591 (0%)
Frame = +1
Query: 82 LAIISVSDKTGLIPLAHGLVSAGLTLIASGGTAKAIRDQGIDVHDVADVTKFPEMLGGRV 261
LA+ SVSDKTGL+ A L + GL L+ASGGTAKA+RD G+ V DV+++T FPEMLGGRV
Sbjct: 6 LALFSVSDKTGLVEFARNLTALGLNLVASGGTAKALRDAGLAVRDVSELTGFPEMLGGRV 65
Query: 262 KTLHPAVHGGILARDTESDRKDLEKHNISFVSVVVCNLYPFKKTVQSKDCSVEEAVENID 441
KTLHPAVH GILAR+ D D+ + + + + VV CNLYPF KTV S +VEEAVE ID
Sbjct: 66 KTLHPAVHAGILARNIPEDNADMARLDFNLIRVVACNLYPFVKTVASPGVTVEEAVEQID 125
Query: 442 IGGVTLLRAAAKNHERVSVICDPADYDHIISELKSG---GTTRERRQLLALKAFEHTTSY 612
IGGVTLLRAAAKNH RV+V+C+P DY + +E++S T+ E R+ LALKAF HT Y
Sbjct: 126 IGGVTLLRAAAKNHARVTVVCEPEDYVVVSTEMQSSESKDTSLETRRQLALKAFTHTAQY 185
Query: 613 DESISGFMRRRFAGNGERALPLRYGTNPHQKDDAELYIVEDEMPIKVLNGSPGYINILDG 792
DE+IS + R++++ G +PLRYG NPHQ A+LY ++ ++PI VLNG+PG+IN+ D
Sbjct: 186 DEAISDYFRKQYS-KGVSQMPLRYGMNPHQTP-AQLYTLQPKLPITVLNGAPGFINLCDA 243
Query: 793 LNGWQLVKELSDATKMPAAASFKHVSPAGAAVGLPLNETEAACCMVSDLPIDTKKPSLXX 972
LN WQLVKEL +A +PAAASFKHVSPAGAAVG+PL+E EA CMV DL T P +
Sbjct: 244 LNAWQLVKELKEALGIPAAASFKHVSPAGAAVGIPLSEDEAKVCMVYDL-YKTLTP-ISA 301
Query: 973 XXXXXXXXXXMSSFGDFIALSEKCDELTAKIINREVSDGVVAPDFDPAALSLLAKKKNGN 1152
MSSFGDF+ALS+ CD TAKII+REVSDG++AP ++ AL++L+KKKNGN
Sbjct: 302 AYARARGADRMSSFGDFVALSDVCDVPTAKIISREVSDGIIAPGYEEEALTILSKKKNGN 361
Query: 1153 YCVLKINPNYLPSETEERTVFGLRLRQKRNNAVINAETFNNVVGSANELNKQAIDDLIVA 1332
YCVL+++ +Y P E E RT+FGL L QKRNN V++ F+NVV +L + A+ DLIVA
Sbjct: 362 YCVLQMDQSYKPDENEVRTLFGLHLSQKRNNGVVDKSLFSNVVTKNKDLPESALRDLIVA 421
Query: 1333 TIALKYAQSNSVCFAHRGQVIGMGAGQQSRIHCTRLAGDKAMNWWLRQHPTVLSLPWKNA 1512
TIA+KY QSNSVC+A GQVIG+GAGQQSRIHCTRLAGDKA WWLR HP VLS+ +K
Sbjct: 422 TIAVKYTQSNSVCYAKNGQVIGIGAGQQSRIHCTRLAGDKANYWWLRHHPQVLSMKFKTG 481
Query: 1513 IKRSEKSNAIDVLCSGVLGSEIAIDQWQQYFNEPVEPLAEDDRKQWLSQQTGVVMSSDAF 1692
+KR+E SNAID +G +G + + +W+ F E E L E ++K+W+ + T V +SSDAF
Sbjct: 482 VKRAEISNAIDQYVTGTIGEDEDLIKWKALFEEVPELLTEAEKKEWVEKLTEVSISSDAF 541
Query: 1693 LPFRDNVDCAKQFGVSYVAHPGGSVRDDDIKEACDEHGITLIHTGLRLFHH 1845
PFRDNVD AK+ GV+Y+A P GS D + EACDE GI L HT LRLFHH
Sbjct: 542 FPFRDNVDRAKRSGVAYIAAPSGSAADKVVIEACDELGIILAHTNLRLFHH 592
>gi|2541906|dbj|BAA22837.1| 5-aminoimidazole-4-carboxamide
ribonucleotide formyltransferase/IMP cyclohydrolase
[Rattus norvegicus]
Length = 592
Score = 676 bits (1744), Expect = 0.0
Identities = 347/591 (58%), Positives = 433/591 (72%), Gaps = 3/591 (0%)
Frame = +1
Query: 82 LAIISVSDKTGLIPLAHGLVSAGLTLIASGGTAKAIRDQGIDVHDVADVTKFPEMLGGRV 261
LA+ SVSDKTGL+ A S GL+L+ASGGTAKAIRD G+ V DV+++T FPEMLGGRV
Sbjct: 6 LALFSVSDKTGLVEFARNHASLGLSLVASGGTAKAIRDAGLAVRDVSELTGFPEMLGGRV 65
Query: 262 KTLHPAVHGGILARDTESDRKDLEKHNISFVSVVVCNLYPFKKTVQSKDCSVEEAVENID 441
KTLHPAVH GILAR+ D D+ + + + + VVVCNLYPF KTV S D +VE AVE ID
Sbjct: 66 KTLHPAVHAGILARNIPEDAADMARLDFNLIRVVVCNLYPFVKTVASPDVTVEAAVEQID 125
Query: 442 IGGVTLLRAAAKNHERVSVICDPADYDHIISELKSGG---TTRERRQLLALKAFEHTTSY 612
IGGVTLLRAAAKNH RV+V+C+P DY + +E++ G T+ E R+ LALKAF HT Y
Sbjct: 126 IGGVTLLRAAAKNHARVTVVCEPEDYGAVAAEMQGSGNKDTSLETRRHLALKAFTHTAQY 185
Query: 613 DESISGFMRRRFAGNGERALPLRYGTNPHQKDDAELYIVEDEMPIKVLNGSPGYINILDG 792
DE+IS + RR+++ G +PLRYG NPHQ A+LY ++ ++PI VLNG+PG+IN+ D
Sbjct: 186 DEAISDYFRRQYS-KGISQMPLRYGMNPHQTP-AQLYTLKPKLPITVLNGAPGFINLCDA 243
Query: 793 LNGWQLVKELSDATKMPAAASFKHVSPAGAAVGLPLNETEAACCMVSDLPIDTKKPSLXX 972
LN WQLV EL A +PAAASFKHVSPAGAAVG+PL+E EA CMV DL T P L
Sbjct: 244 LNAWQLVTELRGAVDIPAAASFKHVSPAGAAVGVPLSEDEARVCMVYDL-YPTLTP-LAI 301
Query: 973 XXXXXXXXXXMSSFGDFIALSEKCDELTAKIINREVSDGVVAPDFDPAALSLLAKKKNGN 1152
MSSFGDF+ALS+ CD TAKII+REVSDG+VAP ++ AL +L+KKKNG+
Sbjct: 302 AYARARGADRMSSFGDFVALSDVCDVPTAKIISREVSDGIVAPGYEEEALKILSKKKNGS 361
Query: 1153 YCVLKINPNYLPSETEERTVFGLRLRQKRNNAVINAETFNNVVGSANELNKQAIDDLIVA 1332
YCVL+++ +Y P E E RT+FGLRL QKRNN V++ F+N+V +L + A+ DLIVA
Sbjct: 362 YCVLQMDQSYKPDENEVRTLFGLRLSQKRNNGVVDKSLFSNIVTKNKDLPESALRDLIVA 421
Query: 1333 TIALKYAQSNSVCFAHRGQVIGMGAGQQSRIHCTRLAGDKAMNWWLRQHPTVLSLPWKNA 1512
TIA+KY QSNSVC+A GQVIG+GAGQQSRIHCTRLAGDKA +WWLR HP VLS+ +K
Sbjct: 422 TIAVKYTQSNSVCYAKDGQVIGIGAGQQSRIHCTRLAGDKANSWWLRHHPRVLSMKFKAG 481
Query: 1513 IKRSEKSNAIDVLCSGVLGSEIAIDQWQQYFNEPVEPLAEDDRKQWLSQQTGVVMSSDAF 1692
+KR+E SNAID +G +G + +W+ F E E L E ++K+W+ + +GV +SSDAF
Sbjct: 482 VKRAEVSNAIDQYVTGTIGEGEDLVKWKALFEEVPELLTEAEKKEWVDKLSGVSVSSDAF 541
Query: 1693 LPFRDNVDCAKQFGVSYVAHPGGSVRDDDIKEACDEHGITLIHTGLRLFHH 1845
PFRDNVD AK+ GV+Y+ P GS D + EACDE GI L HT LRLFHH
Sbjct: 542 FPFRDNVDRAKRSGVAYIVAPSGSTADKVVIEACDELGIVLAHTDLRLFHH 592
>gi|37572276|gb|AAH39925.2| 5-aminoimidazole-4-carboxamide
ribonucleotide formyltransferase/IMP cyclohydrolase [Mus
musculus]
Length = 592
Score = 674 bits (1738), Expect = 0.0
Identities = 347/591 (58%), Positives = 432/591 (72%), Gaps = 3/591 (0%)
Frame = +1
Query: 82 LAIISVSDKTGLIPLAHGLVSAGLTLIASGGTAKAIRDQGIDVHDVADVTKFPEMLGGRV 261
LA+ SVSDKTGL+ A L S GL+L+ASGGTAKAIRD G+ V DV+++T FPEMLGGRV
Sbjct: 6 LALFSVSDKTGLVEFARSLASLGLSLVASGGTAKAIRDAGLAVRDVSELTGFPEMLGGRV 65
Query: 262 KTLHPAVHGGILARDTESDRKDLEKHNISFVSVVVCNLYPFKKTVQSKDCSVEEAVENID 441
KTLHPAVH GILAR+ D D+ + + + V VVVCNLYPF KTV S D +VE AVE ID
Sbjct: 66 KTLHPAVHAGILARNIPEDAADMARLDFNLVRVVVCNLYPFVKTVASPDVTVEAAVEQID 125
Query: 442 IGGVTLLRAAAKNHERVSVICDPADYDHIISELK---SGGTTRERRQLLALKAFEHTTSY 612
IGGVTLLRAAAKNH RV+V+C+P DY + +E+ S T+ E R+ LALKAF HT Y
Sbjct: 126 IGGVTLLRAAAKNHARVTVVCEPEDYAGVAAEMHGSDSKDTSLETRRHLALKAFTHTAQY 185
Query: 613 DESISGFMRRRFAGNGERALPLRYGTNPHQKDDAELYIVEDEMPIKVLNGSPGYINILDG 792
DE+IS + R++++ G +PLRYG NPHQ A+ Y ++ ++PI VLNG+PG+IN+ D
Sbjct: 186 DEAISDYFRKQYS-KGISQMPLRYGMNPHQTP-AQSYTLKPKLPITVLNGAPGFINLCDA 243
Query: 793 LNGWQLVKELSDATKMPAAASFKHVSPAGAAVGLPLNETEAACCMVSDLPIDTKKPSLXX 972
LN WQLV EL A +PAAASFKHVSPAGAAVG+PL+E EA CMV DL T P L
Sbjct: 244 LNAWQLVTELRGAVDIPAAASFKHVSPAGAAVGVPLSEDEARVCMVYDL-YPTLTP-LAV 301
Query: 973 XXXXXXXXXXMSSFGDFIALSEKCDELTAKIINREVSDGVVAPDFDPAALSLLAKKKNGN 1152
MSSFGDF+ALS+ CD TAKII+REVSDG+VAP ++ AL +L+KKKNGN
Sbjct: 302 AYARARGADRMSSFGDFVALSDICDVPTAKIISREVSDGIVAPGYEEEALKILSKKKNGN 361
Query: 1153 YCVLKINPNYLPSETEERTVFGLRLRQKRNNAVINAETFNNVVGSANELNKQAIDDLIVA 1332
YCVL+++ +Y P E E RT+FGLRL QKRNN V++ F+N+V +L + A+ DLIVA
Sbjct: 362 YCVLQMDQSYKPDENEVRTLFGLRLSQKRNNGVVDKSLFSNIVTKNKDLPESALRDLIVA 421
Query: 1333 TIALKYAQSNSVCFAHRGQVIGMGAGQQSRIHCTRLAGDKAMNWWLRQHPTVLSLPWKNA 1512
T+A+KY QSNSVC+A GQVIG+GAGQQSRIHCTRLAGDKA +WWLR HP VLS+ +K
Sbjct: 422 TVAVKYTQSNSVCYAKDGQVIGIGAGQQSRIHCTRLAGDKANSWWLRHHPRVLSMKFKAG 481
Query: 1513 IKRSEKSNAIDVLCSGVLGSEIAIDQWQQYFNEPVEPLAEDDRKQWLSQQTGVVMSSDAF 1692
+KR+E SNAID +G +G + +W+ F E E L E ++K+W+ + +GV +SSDAF
Sbjct: 482 VKRAEISNAIDQYVTGTIGEGEDLVKWEALFEEVPELLTEAEKKEWVDKLSGVSVSSDAF 541
Query: 1693 LPFRDNVDCAKQFGVSYVAHPGGSVRDDDIKEACDEHGITLIHTGLRLFHH 1845
PFRDNVD AK+ GV+Y+ P GS D + EACDE GI L HT LRLFHH
Sbjct: 542 FPFRDNVDRAKRSGVAYIVAPSGSTADKVVIEACDELGIVLAHTDLRLFHH 592
>gi|27229048|ref|NP_080471.1| 5-aminoimidazole-4-carboxamide
ribonucleotide formyltransferase/IMP cyclohydrolase [Mus
musculus]
gi|15214215|sp|Q9CWJ9|PUR9_MOUSE Bifunctional purine biosynthesis
protein PURH [Includes:
Phosphoribosylaminoimidazolecarboxamide formyltransferase
(AICAR transformylase); IMP cyclohydrolase (Inosinicase)
(IMP synthetase) (ATIC)]
gi|12846177|dbj|BAB27060.1| unnamed protein product [Mus musculus]
Length = 592
Score = 672 bits (1735), Expect = 0.0
Identities = 347/591 (58%), Positives = 432/591 (72%), Gaps = 3/591 (0%)
Frame = +1
Query: 82 LAIISVSDKTGLIPLAHGLVSAGLTLIASGGTAKAIRDQGIDVHDVADVTKFPEMLGGRV 261
LA+ SVSDKTGL+ A L S GL+L+ASGGTAKAIRD G+ V DV+++T FPEMLGGRV
Sbjct: 6 LALFSVSDKTGLVEFARSLASLGLSLVASGGTAKAIRDAGLAVRDVSELTGFPEMLGGRV 65
Query: 262 KTLHPAVHGGILARDTESDRKDLEKHNISFVSVVVCNLYPFKKTVQSKDCSVEEAVENID 441
KTLHPAVH GILAR+ D D+ + + + V VVVCNLYPF KTV S D +VE AVE ID
Sbjct: 66 KTLHPAVHAGILARNIPEDAADMARLDFNLVRVVVCNLYPFVKTVASPDVTVEAAVEQID 125
Query: 442 IGGVTLLRAAAKNHERVSVICDPADYDHIISELK---SGGTTRERRQLLALKAFEHTTSY 612
IGGVTLLRAAAKNH RV+V+C+P DY + +E+ S T+ E R+ LALKAF HT Y
Sbjct: 126 IGGVTLLRAAAKNHARVTVVCEPEDYAGVAAEMHGSDSKDTSLETRRHLALKAFTHTAQY 185
Query: 613 DESISGFMRRRFAGNGERALPLRYGTNPHQKDDAELYIVEDEMPIKVLNGSPGYINILDG 792
DE+IS + R++++ G +PLRYG NPHQ A+LY ++ ++PI VLNG+PG+IN+ D
Sbjct: 186 DEAISDYFRKQYS-KGISQMPLRYGMNPHQTP-AQLYTLKPKLPITVLNGAPGFINLCDA 243
Query: 793 LNGWQLVKELSDATKMPAAASFKHVSPAGAAVGLPLNETEAACCMVSDLPIDTKKPSLXX 972
LN WQLV EL A +PAAASFKHVSPAGAAVG+PL+E EA CMV DL T P L
Sbjct: 244 LNAWQLVTELRGAVDIPAAASFKHVSPAGAAVGVPLSEDEARVCMVYDL-YPTLTP-LAV 301
Query: 973 XXXXXXXXXXMSSFGDFIALSEKCDELTAKIINREVSDGVVAPDFDPAALSLLAKKKNGN 1152
MSSFGDF+ALS+ CD TAKII+REVSDG+VAP ++ AL +L+KKKNGN
Sbjct: 302 AYARARGADRMSSFGDFVALSDICDVPTAKIISREVSDGIVAPGYEEEALKILSKKKNGN 361
Query: 1153 YCVLKINPNYLPSETEERTVFGLRLRQKRNNAVINAETFNNVVGSANELNKQAIDDLIVA 1332
YCVL+++ + P E E RT+FGLRL QKRNN V++ F+N+V +L + A+ DLIVA
Sbjct: 362 YCVLQMDQSCKPDENEVRTLFGLRLSQKRNNGVVDKSLFSNIVTKNKDLPESALRDLIVA 421
Query: 1333 TIALKYAQSNSVCFAHRGQVIGMGAGQQSRIHCTRLAGDKAMNWWLRQHPTVLSLPWKNA 1512
T+A+KY QSNSVC+A GQVIG+GAGQQSRIHCTRLAGDKA +WWLR HP VLS+ +K
Sbjct: 422 TVAVKYTQSNSVCYAKDGQVIGIGAGQQSRIHCTRLAGDKANSWWLRHHPRVLSMKFKAG 481
Query: 1513 IKRSEKSNAIDVLCSGVLGSEIAIDQWQQYFNEPVEPLAEDDRKQWLSQQTGVVMSSDAF 1692
+KR+E SNAID +G +G + +W+ F E E L E ++K+W+ + +GV +SSDAF
Sbjct: 482 VKRAEISNAIDQYVTGTIGEGEDLVKWEALFEEVPELLTEAEKKEWVDKLSGVSVSSDAF 541
Query: 1693 LPFRDNVDCAKQFGVSYVAHPGGSVRDDDIKEACDEHGITLIHTGLRLFHH 1845
PFRDNVD AK+ GV+Y+ P GS D + EACDE GI L HT LRLFHH
Sbjct: 542 FPFRDNVDRAKRSGVAYIVAPSGSTADKVVIEACDELGIVLAHTDLRLFHH 592
>gi|48734658|gb|AAH72321.1| Unknown (protein for IMAGE:6317471)
[Xenopus laevis]
Length = 593
Score = 671 bits (1730), Expect = 0.0
Identities = 347/600 (57%), Positives = 436/600 (71%), Gaps = 3/600 (0%)
Frame = +1
Query: 55 LCEMTDGKSLAIISVSDKTGLIPLAHGLVSAGLTLIASGGTAKAIRDQGIDVHDVADVTK 234
L EM + +A+ SVSDK+GL+ A L + GL+L+ASGGTAK +RD G+ V DV+++T
Sbjct: 2 LAEMAE---IALFSVSDKSGLVEFAQQLSTLGLSLVASGGTAKCLRDAGLSVRDVSEITG 58
Query: 235 FPEMLGGRVKTLHPAVHGGILARDTESDRKDLEKHNISFVSVVVCNLYPFKKTVQSKDCS 414
FPEMLGGRVKTLHPAVH GILAR + D+ D+ + S++ VVVCNLYPF KTV + +
Sbjct: 59 FPEMLGGRVKTLHPAVHAGILARSSPEDQADVSRLGFSYIRVVVCNLYPFVKTVSAAGVT 118
Query: 415 VEEAVENIDIGGVTLLRAAAKNHERVSVICDPADYDHIISELKSG---GTTRERRQLLAL 585
VEEAVE IDIGGVTLLRAAAKNH RV+V+CDP+DY I E+ TT E R LAL
Sbjct: 119 VEEAVEQIDIGGVTLLRAAAKNHARVTVVCDPSDYKCIAEEMGKSDKKNTTPETRCQLAL 178
Query: 586 KAFEHTTSYDESISGFMRRRFAGNGERALPLRYGTNPHQKDDAELYIVEDEMPIKVLNGS 765
KAF HT YD++IS + R++++ G LPLRYG NPHQ A++Y ++P+ VLNGS
Sbjct: 179 KAFTHTAQYDDAISDYFRKQYS-KGISQLPLRYGINPHQVP-AQIYTRGPQLPLTVLNGS 236
Query: 766 PGYINILDGLNGWQLVKELSDATKMPAAASFKHVSPAGAAVGLPLNETEAACCMVSDLPI 945
PG+IN+ D LN WQLV+EL +A +PAA SFKHVSPAGAAVG+PL E EA CMV D+
Sbjct: 237 PGFINLCDALNAWQLVRELKNALGLPAATSFKHVSPAGAAVGVPLTEEEAQVCMVQDI-F 295
Query: 946 DTKKPSLXXXXXXXXXXXXMSSFGDFIALSEKCDELTAKIINREVSDGVVAPDFDPAALS 1125
T P L MSSFGDFIA+S+ CD TAKII+REVSDG+VAP ++ AL
Sbjct: 296 PTLTP-LATAYARARGADRMSSFGDFIAVSDVCDVATAKIISREVSDGIVAPGYEDEALK 354
Query: 1126 LLAKKKNGNYCVLKINPNYLPSETEERTVFGLRLRQKRNNAVINAETFNNVVGSANELNK 1305
+L+KKKNG+YCVL+++ +Y PS+ E R++FGL+L QKRNNAVI+ FNNVV + E+ +
Sbjct: 355 ILSKKKNGSYCVLQMDLSYEPSDIEIRSLFGLQLEQKRNNAVIDRTLFNNVVTNNKEIPE 414
Query: 1306 QAIDDLIVATIALKYAQSNSVCFAHRGQVIGMGAGQQSRIHCTRLAGDKAMNWWLRQHPT 1485
A+ DLIVATIALKY QSNSVC+A GQVIGMGAGQQSRIHCTRLAGDKA NWWLR HP
Sbjct: 415 SAVRDLIVATIALKYTQSNSVCYAKDGQVIGMGAGQQSRIHCTRLAGDKADNWWLRHHPR 474
Query: 1486 VLSLPWKNAIKRSEKSNAIDVLCSGVLGSEIAIDQWQQYFNEPVEPLAEDDRKQWLSQQT 1665
VL + +K +KR+E SNAID SG LG E + QWQ ++EP E L +++ W+S+ +
Sbjct: 475 VLGMKFKAGVKRAEISNAIDQYVSGTLGEE-DLPQWQALYDEPPEQLTLAEKRDWISKLS 533
Query: 1666 GVVMSSDAFLPFRDNVDCAKQFGVSYVAHPGGSVRDDDIKEACDEHGITLIHTGLRLFHH 1845
GV +SSDAF PF+DN++ AK+ GV +A P GS D + +AC+E GI L HT LRLFHH
Sbjct: 534 GVSLSSDAFFPFKDNLERAKKSGVQSIAAPSGSAADKVVIDACNELGIVLAHTNLRLFHH 593
>gi|14278285|pdb|1G8M|A Chain A, Crystal Structure Of Avian Atic, A
Bifunctional Transformylase And Cyclohydrolase Enzyme In
Purine Biosynthesis At 1.75 Ang. Resolution
gi|14278286|pdb|1G8M|B Chain B, Crystal Structure Of Avian Atic, A
Bifunctional Transformylase And Cyclohydrolase Enzyme In
Purine Biosynthesis At 1.75 Ang. Resolution
Length = 593
Score = 668 bits (1723), Expect = 0.0
Identities = 348/597 (58%), Positives = 422/597 (70%), Gaps = 3/597 (0%)
Frame = +1
Query: 64 MTDGKSLAIISVSDKTGLIPLAHGLVSAGLTLIASGGTAKAIRDQGIDVHDVADVTKFPE 243
M + LA++SVS+K GL+ A L + GL LIASGGTA A+RD G+ V DV+D+T FPE
Sbjct: 1 MAARQQLALLSVSEKAGLVEFARSLNALGLGLIASGGTATALRDAGLPVRDVSDLTGFPE 60
Query: 244 MLGGRVKTLHPAVHGGILARDTESDRKDLEKHNISFVSVVVCNLYPFKKTVQSKDCSVEE 423
LGGRVKTLHPAVH GILAR+ D D K + S V VVVCNLYPF KTV S +V E
Sbjct: 61 XLGGRVKTLHPAVHAGILARNIPEDNADXNKQDFSLVRVVVCNLYPFVKTVSSPGVTVPE 120
Query: 424 AVENIDIGGVTLLRAAAKNHERVSVICDPADYDHIISEL---KSGGTTRERRQLLALKAF 594
AVE IDIGGV LLRAAAKNH RV+V+CDPADY + E K T+ E R+ LALKAF
Sbjct: 121 AVEKIDIGGVALLRAAAKNHARVTVVCDPADYSSVAKEXAASKDKDTSVETRRHLALKAF 180
Query: 595 EHTTSYDESISGFMRRRFAGNGERALPLRYGTNPHQKDDAELYIVEDEMPIKVLNGSPGY 774
HT YD +IS + R+ ++ G LPLRYG NPHQ A+LY ++P+ V+NGSPG+
Sbjct: 181 THTAQYDAAISDYFRKEYS-KGVSQLPLRYGXNPHQSP-AQLYTTRPKLPLTVVNGSPGF 238
Query: 775 INILDGLNGWQLVKELSDATKMPAAASFKHVSPAGAAVGLPLNETEAACCMVSDLPIDTK 954
IN+ D LN WQLVKEL A +PAAASFKHVSPAGAAVG+PL+E EA C V DL T
Sbjct: 239 INLCDALNAWQLVKELKQALGIPAAASFKHVSPAGAAVGIPLSEEEAQVCXVHDLH-KTL 297
Query: 955 KPSLXXXXXXXXXXXXMSSFGDFIALSEKCDELTAKIINREVSDGVVAPDFDPAALSLLA 1134
P L SSFGDFIALS+ CD TAKII+REVSDGVVAP ++ AL +L+
Sbjct: 298 TP-LASAYARSRGADRXSSFGDFIALSDICDVPTAKIISREVSDGVVAPGYEEEALKILS 356
Query: 1135 KKKNGNYCVLKINPNYLPSETEERTVFGLRLRQKRNNAVINAETFNNVVGSANELNKQAI 1314
KKKNG YCVL+ +PNY P + E RT++GL+L QKRNNAVI+ F N+V L + A+
Sbjct: 357 KKKNGGYCVLQXDPNYEPDDNEIRTLYGLQLXQKRNNAVIDRSLFKNIVTKNKTLPESAV 416
Query: 1315 DDLIVATIALKYAQSNSVCFAHRGQVIGMGAGQQSRIHCTRLAGDKAMNWWLRQHPTVLS 1494
DLIVA+IA+KY QSNSVC+A GQVIG+GAGQQSRIHCTRLAGDKA +WWLR HP VLS
Sbjct: 417 RDLIVASIAVKYTQSNSVCYAKDGQVIGIGAGQQSRIHCTRLAGDKANSWWLRHHPRVLS 476
Query: 1495 LPWKNAIKRSEKSNAIDVLCSGVLGSEIAIDQWQQYFNEPVEPLAEDDRKQWLSQQTGVV 1674
+K +KR+E SNAID +G +G + + +WQ F E L E ++KQW+++ T V
Sbjct: 477 XKFKAGVKRAEVSNAIDQYVTGTIGEDEDLVKWQAXFEEVPAQLTEAEKKQWIAKLTAVS 536
Query: 1675 MSSDAFLPFRDNVDCAKQFGVSYVAHPGGSVRDDDIKEACDEHGITLIHTGLRLFHH 1845
+SSDAF PFRDNVD AK+ GV ++ P GS D+ + EAC+E GITLIHT LRLFHH
Sbjct: 537 LSSDAFFPFRDNVDRAKRIGVQFIVAPSGSAADEVVIEACNELGITLIHTNLRLFHH 593
>gi|31242553|ref|XP_321707.1| ENSANGP00000015783 [Anopheles gambiae]
gi|21289473|gb|EAA01766.1| ENSANGP00000015783 [Anopheles gambiae str.
PEST]
Length = 640
Score = 665 bits (1715), Expect = 0.0
Identities = 335/595 (56%), Positives = 427/595 (71%), Gaps = 1/595 (0%)
Frame = +1
Query: 64 MTDGKSLAIISVSDKTGLIPLAHGLVSAGLTLIASGGTAKAIRDQGIDVHDVADVTKFPE 243
M GK +A++SVSDK+GL+ A GL GL L+ASGGTAKAIRD G+ V DV+D+T PE
Sbjct: 51 MASGK-IALVSVSDKSGLVEFAKGLNELGLKLVASGGTAKAIRDLGLPVRDVSDITGAPE 109
Query: 244 MLGGRVKTLHPAVHGGILARDTESDRKDLEKHNISFVSVVVCNLYPFKKTVQSKDCSVEE 423
MLGGRVKTLHPAVH ILAR TESD++D+ + +VVCNLYPF T+ D ++ +
Sbjct: 110 MLGGRVKTLHPAVHAAILARMTESDQRDISQQKYELAQLVVCNLYPFGLTISKPDVTIAD 169
Query: 424 AVENIDIGGVTLLRAAAKNHERVSVICDPADYDHIISELKS-GGTTRERRQLLALKAFEH 600
AVENIDIGGVTLLRAAAKNH+RV+V+CDP DY ++ E++ G TT RQLLALKAF H
Sbjct: 170 AVENIDIGGVTLLRAAAKNHQRVTVLCDPKDYPKVLEEIRQHGDTTPATRQLLALKAFTH 229
Query: 601 TTSYDESISGFMRRRFAGNGERALPLRYGTNPHQKDDAELYIVEDEMPIKVLNGSPGYIN 780
T YD IS + R++++ G L LRYG NPHQK A+++ + + +P+KV+N SPG+IN
Sbjct: 230 TAEYDAIISDYFRKQYSA-GVSQLNLRYGMNPHQKP-AQIFTLLERLPLKVVNASPGFIN 287
Query: 781 ILDGLNGWQLVKELSDATKMPAAASFKHVSPAGAAVGLPLNETEAACCMVSDLPIDTKKP 960
+ D LNGWQLV+EL A +PAA SFKHVSPAGAAVG+ L+ +A CMV D+ +D+ P
Sbjct: 288 LCDALNGWQLVRELKRALGLPAATSFKHVSPAGAAVGVALSLEQAKLCMVDDM-MDSLTP 346
Query: 961 SLXXXXXXXXXXXXMSSFGDFIALSEKCDELTAKIINREVSDGVVAPDFDPAALSLLAKK 1140
+ MSSFGDF+ALS+ CD TAKII REVSDG++AP + AL +L KK
Sbjct: 347 -MATAYARARGADRMSSFGDFVALSDTCDLATAKIIAREVSDGIIAPGYTEEALEVLRKK 405
Query: 1141 KNGNYCVLKINPNYLPSETEERTVFGLRLRQKRNNAVINAETFNNVVGSANELNKQAIDD 1320
KNG+YCVL+I+P Y P E +T+FGL+L Q+RN+A IN F N+V L + A+ D
Sbjct: 406 KNGSYCVLQIDPTYEPGPVERKTLFGLQLEQRRNDADINKALFTNIVTKNKTLPEGALRD 465
Query: 1321 LIVATIALKYAQSNSVCFAHRGQVIGMGAGQQSRIHCTRLAGDKAMNWWLRQHPTVLSLP 1500
LIVATIALKY QSNSVC+A GQV+G+GAGQQSRIHCTRLAGDKA NWWLRQHP V +
Sbjct: 466 LIVATIALKYTQSNSVCYAKDGQVVGIGAGQQSRIHCTRLAGDKADNWWLRQHPRVAGMQ 525
Query: 1501 WKNAIKRSEKSNAIDVLCSGVLGSEIAIDQWQQYFNEPVEPLAEDDRKQWLSQQTGVVMS 1680
++ +KR+E SNAID +G +G ++ + Q++ + PL +D++QW Q TGV +
Sbjct: 526 FRKGVKRAEISNAIDNYVNGTVGKDMPVAQFEAMLEKVPAPLTGEDKEQWTRQLTGVSLG 585
Query: 1681 SDAFLPFRDNVDCAKQFGVSYVAHPGGSVRDDDIKEACDEHGITLIHTGLRLFHH 1845
SDAF PFRDNVD AK GVSY+A P GS D + +AC+EH I ++HT LRLFHH
Sbjct: 586 SDAFFPFRDNVDRAKLSGVSYIASPAGSTNDAGVIDACNEHDIVMVHTNLRLFHH 640
>gi|34305305|gb|AAQ63487.1| 5-aminoimidazole-4-carboxamide
ribonucleotide formyltransferase/IMP cyclohydrolase
[Leptinotarsa decemlineata]
Length = 594
Score = 655 bits (1690), Expect = 0.0
Identities = 327/596 (54%), Positives = 428/596 (70%), Gaps = 3/596 (0%)
Frame = +1
Query: 67 TDGKSLAIISVSDKTGLIPLAHGLVSAGLTLIASGGTAKAIRDQGIDVHDVADVTKFPEM 246
T+ +A++SVSDK GL+ + L + G TL+ SGGTA +R G+ + DV++++ PE+
Sbjct: 3 TNSGKIALLSVSDKIGLVDIGKKLHTLGFTLVGSGGTAAILRGAGLPIKDVSEISGAPEI 62
Query: 247 LGGRVKTLHPAVHGGILARDTESDRKDLEKHNISFVSVVVCNLYPFKKTVQSKDCSVEEA 426
LGGRVKTLHPAVHGGILAR SD++DL K NI + +V+CNLYPFK+TV +D ++ +A
Sbjct: 63 LGGRVKTLHPAVHGGILARLQPSDQEDLRKQNIEMIRIVICNLYPFKETVSKEDVTLSDA 122
Query: 427 VENIDIGGVTLLRAAAKNHERVSVICDPADYDHIISELKSG---GTTRERRQLLALKAFE 597
VENIDIGGVTLLRAAAKNHERV+V+ DPADY+ I+ E++S TT E R+ LALKAF
Sbjct: 123 VENIDIGGVTLLRAAAKNHERVTVVVDPADYNKILQEIRSSPNNDTTIETRRTLALKAFT 182
Query: 598 HTTSYDESISGFMRRRFAGNGERALPLRYGTNPHQKDDAELYIVEDEMPIKVLNGSPGYI 777
HT YD +IS + R+ F+ N + L LRYG NPHQK A+LY +++P+ V+NGSPG+I
Sbjct: 183 HTCQYDLAISDYFRKEFSQN-QSQLSLRYGMNPHQKP-AQLYTTLEKLPLTVVNGSPGFI 240
Query: 778 NILDGLNGWQLVKELSDATKMPAAASFKHVSPAGAAVGLPLNETEAACCMVSDLPIDTKK 957
N+ D LN WQLVKEL +PAA SFKHVSPAGAAVG+PL+ +A CMV D+ ++
Sbjct: 241 NLCDALNSWQLVKELKTVIGLPAATSFKHVSPAGAAVGIPLDHNQAKLCMVDDI-LEELS 299
Query: 958 PSLXXXXXXXXXXXXMSSFGDFIALSEKCDELTAKIINREVSDGVVAPDFDPAALSLLAK 1137
P L MSSFGDF+ALS+ CD TA++I+REVSDGV+AP + P AL LL K
Sbjct: 300 P-LAIAYARARGADRMSSFGDFVALSDICDHPTARLISREVSDGVIAPGYTPEALELLRK 358
Query: 1138 KKNGNYCVLKINPNYLPSETEERTVFGLRLRQKRNNAVINAETFNNVVGSANELNKQAID 1317
K+NGNY VL+I+PNY P+ E + +FGL L Q+RN+A+I+ F N+V L + A+
Sbjct: 359 KENGNYSVLQIDPNYNPNPIETKVIFGLTLEQRRNDALIDKSLFKNIVSDNKNLPEDAVR 418
Query: 1318 DLIVATIALKYAQSNSVCFAHRGQVIGMGAGQQSRIHCTRLAGDKAMNWWLRQHPTVLSL 1497
DLIVATIALKY QSNSVC+A GQV+G+GAGQQSRIHCTRLAGDKA NWW+RQHP VL +
Sbjct: 419 DLIVATIALKYTQSNSVCYAKDGQVVGIGAGQQSRIHCTRLAGDKADNWWMRQHPKVLGM 478
Query: 1498 PWKNAIKRSEKSNAIDVLCSGVLGSEIAIDQWQQYFNEPVEPLAEDDRKQWLSQQTGVVM 1677
++ +KR+E SNAID +G +G ++ ++ ++ +E +R+ WLSQ GV +
Sbjct: 479 KFRKGVKRAEISNAIDNFVNGSVGKDMDRSIFESMYDVVPIEFSETERRTWLSQLKGVAL 538
Query: 1678 SSDAFLPFRDNVDCAKQFGVSYVAHPGGSVRDDDIKEACDEHGITLIHTGLRLFHH 1845
+SDAF PFRDNVD A+ GVSY+ P GS D+++ AC+EH I L HT LRLFHH
Sbjct: 539 ASDAFFPFRDNVDRARLSGVSYIGCPSGSTNDEEVVRACNEHKIVLAHTNLRLFHH 594
>gi|46439064|gb|EAK98386.1| hypothetical protein CaO19.492 [Candida
albicans SC5314]
gi|46439157|gb|EAK98478.1| hypothetical protein CaO19.8122 [Candida
albicans SC5314]
Length = 592
Score = 648 bits (1672), Expect = 0.0
Identities = 338/588 (57%), Positives = 409/588 (69%), Gaps = 1/588 (0%)
Frame = +1
Query: 85 AIISVSDKTGLIPLAHGLVSAGLTLIASGGTAKAIRDQGIDVHDVADVTKFPEMLGGRVK 264
AI+SV DKTGL+ LA GLV+A + ++ASGGTAK IR+ G V DV+ +T PEMLGGRVK
Sbjct: 10 AILSVYDKTGLLDLAKGLVAANVRILASGGTAKLIREAGFPVEDVSSITHAPEMLGGRVK 69
Query: 265 TLHPAVHGGILARDTESDRKDLEKHNISFVSVVVCNLYPFKKTVQSKDCSVEEAVENIDI 444
TLHPAVHGGILAR+ ESD DL I V VVCNLYPFK+T+ +V EAVE IDI
Sbjct: 70 TLHPAVHGGILARNLESDEHDLTAQGIEKVDFVVCNLYPFKETISKVAVTVPEAVEEIDI 129
Query: 445 GGVTLLRAAAKNHERVSVICDPADYDHIISELKSGGTTRERRQLLALKAFEHTTSYDESI 624
GGVTLLRAAAKNHERVS++ DP DY H + ELKSG T E R LALKAFEHT YD +I
Sbjct: 130 GGVTLLRAAAKNHERVSILSDPQDYAHFLEELKSGEITAETRNRLALKAFEHTADYDVAI 189
Query: 625 SGFMRRRFAGNGERALPLRYGTNPHQKDDAELYIVEDEMPIKVLNGSPGYINILDGLNGW 804
S F R+++A N + LPLRYG NPHQK A+ ++ E E+P KVLNGSPGYIN+LD LN W
Sbjct: 190 SDFFRKQYAENISQ-LPLRYGANPHQK-PAQAFVSEGELPFKVLNGSPGYINLLDALNSW 247
Query: 805 QLVKELSDATKMPAAASFKHVSPAGAAVGLPLNETEAACCMVSDLPIDTKKPSLXXXXXX 984
LVKELS + +PAAASFKHVSPAGAAVGLPL + E V D I+ P L
Sbjct: 248 PLVKELSASLNLPAAASFKHVSPAGAAVGLPLTDIEKKIYFVED--IENLSP-LANAYAR 304
Query: 985 XXXXXXMSSFGDFIALSEKCDELTAKIINREVSDGVVAPDFDPAALSLLAKKKNGNYCVL 1164
MSSFGDFIALS D+ TA+II++EVSDGV+AP + AL LL KKKNG YC+L
Sbjct: 305 ARGADRMSSFGDFIALSNIVDKPTAQIISKEVSDGVIAPGYSEEALELLKKKKNGKYCIL 364
Query: 1165 KINPNYLPSETEERTVFGLRLRQKRNNAVINAETFNNVVGSANELNKQAIDDLIVATIAL 1344
+I+PNY P E R V+G+ L+QKRN+A+ +F +V +L +Q DL +ATIAL
Sbjct: 365 QIDPNYNPENLESRQVYGITLQQKRNDAIFKGSSFKEIVSKNKDLTEQGAVDLTIATIAL 424
Query: 1345 KYAQSNSVCFAHRGQVIGMGAGQQSRIHCTRLAGDKAMNWWLRQHPTVLSLPWKNAIKRS 1524
KY QSNSVC+A G VIG+GAGQQSRIHCTRLAGDKA NWWLRQHP VL W KR
Sbjct: 425 KYTQSNSVCYAKNGMVIGLGAGQQSRIHCTRLAGDKADNWWLRQHPKVLGFKWAKGTKRP 484
Query: 1525 EKSNAIDVLCSGVLGS-EIAIDQWQQYFNEPVEPLAEDDRKQWLSQQTGVVMSSDAFLPF 1701
EKSNAID+ + + + E +++ F E EPL ++RK+WLS+ + V +SSDAF PF
Sbjct: 485 EKSNAIDLYVTNQIPTEEPEKSEYESKFAEIPEPLTAEERKEWLSKLSNVALSSDAFFPF 544
Query: 1702 RDNVDCAKQFGVSYVAHPGGSVRDDDIKEACDEHGITLIHTGLRLFHH 1845
DNV A + GV ++A P GSV D + A D + I + +RLFHH
Sbjct: 545 PDNVYRAARSGVKFIAAPSGSVMDKAVFAAADANDIVYVENPIRLFHH 592
>gi|50551513|ref|XP_503230.1| hypothetical protein [Yarrowia
lipolytica]
gi|49649098|emb|CAG81431.1| unnamed protein product [Yarrowia
lipolytica CLIB99]
Length = 590
Score = 645 bits (1664), Expect = 0.0
Identities = 335/595 (56%), Positives = 419/595 (70%), Gaps = 1/595 (0%)
Frame = +1
Query: 64 MTDGKSLAIISVSDKTGLIPLAHGLVSAGLTLIASGGTAKAIRDQGIDVHDVADVTKFPE 243
M++ + +AI+SV DKTGL+ LA GLV + L+ASGGTAK +R+ G V DV+ +T PE
Sbjct: 1 MSERQKIAILSVYDKTGLLDLAKGLVKNNVRLLASGGTAKLVREAGFPVEDVSAITHAPE 60
Query: 244 MLGGRVKTLHPAVHGGILARDTESDRKDLEKHNISFVSVVVCNLYPFKKTVQSKDCSVEE 423
ML GRVKTLHPAVHGGILAR+ ESD KDL I V VVCNLYPF+ TV + ++EE
Sbjct: 61 MLSGRVKTLHPAVHGGILARNIESDEKDLSAQGIDKVDFVVCNLYPFQDTVAKINVTIEE 120
Query: 424 AVENIDIGGVTLLRAAAKNHERVSVICDPADYDHIISELKSGGTTRERRQLLALKAFEHT 603
AVE IDIGGVTLLRAAAKNH RV+++ DP DY ++EL G + E R LALKAFEHT
Sbjct: 121 AVEEIDIGGVTLLRAAAKNHSRVTILSDPRDYHAFLNELDHGAISAETRNRLALKAFEHT 180
Query: 604 TSYDESISGFMRRRFAGNGERALPLRYGTNPHQKDDAELYIVEDEMPIKVLNGSPGYINI 783
YD +IS F R++++ + + +PLRYG NPHQK A+ ++ + E+P KVL GSPGYIN+
Sbjct: 181 ADYDSAISDFFRKQYSEDLSQ-MPLRYGANPHQKP-AQAFVQQGELPFKVLCGSPGYINL 238
Query: 784 LDGLNGWQLVKELSDATKMPAAASFKHVSPAGAAVGLPLNETEAACCMVSDLPIDTKKPS 963
LD LN W LVKELS + +PAAASFKHVSPAGAAVGLPL++ E V D I+ P
Sbjct: 239 LDALNSWPLVKELSASLNLPAAASFKHVSPAGAAVGLPLSDIEKKIYFVED--IENLSP- 295
Query: 964 LXXXXXXXXXXXXMSSFGDFIALSEKCDELTAKIINREVSDGVVAPDFDPAALSLLAKKK 1143
L MSSFGDFIALS D TA+II++EVSDGV+AP ++P AL LL KKK
Sbjct: 296 LANAYARARGADRMSSFGDFIALSNIVDLPTAQIISKEVSDGVIAPGYEPEALELLKKKK 355
Query: 1144 NGNYCVLKINPNYLPSETEERTVFGLRLRQKRNNAVINAETFNNVVGSANELNKQAIDDL 1323
G YCVL+I+PN+ P E R V+G+ L+QKRN+AVI++ +F +V EL +QAI DL
Sbjct: 356 GGKYCVLQIDPNFTPGPVETRQVYGISLQQKRNDAVISSNSFKELVSKNKELPEQAIIDL 415
Query: 1324 IVATIALKYAQSNSVCFAHRGQVIGMGAGQQSRIHCTRLAGDKAMNWWLRQHPTVLSLPW 1503
VATIALKY QSNSVC+A G VIG+GAGQQSRIHCTRLAGDKA NWW RQHP VL+ W
Sbjct: 416 TVATIALKYTQSNSVCYAKDGMVIGLGAGQQSRIHCTRLAGDKADNWWFRQHPKVLAFKW 475
Query: 1504 KNAIKRSEKSNAIDVLCSG-VLGSEIAIDQWQQYFNEPVEPLAEDDRKQWLSQQTGVVMS 1680
K KR +KSNAID+ SG + S + ++++ F EPL ++RK+WL + T V +S
Sbjct: 476 KKGTKRPDKSNAIDLYVSGQIPQSGVEKEEYEAKFETVPEPLTAEERKEWLGKLTKVALS 535
Query: 1681 SDAFLPFRDNVDCAKQFGVSYVAHPGGSVRDDDIKEACDEHGITLIHTGLRLFHH 1845
SDAF PF DNV A + GVSY++ P GSV+D+ + A D GI + +RLFHH
Sbjct: 536 SDAFFPFPDNVYRAARSGVSYISAPSGSVQDEAVFAAADSFGIAYVENNIRLFHH 590
>gi|50311693|ref|XP_455873.1| unnamed protein product [Kluyveromyces
lactis]
gi|49645009|emb|CAG98581.1| unnamed protein product [Kluyveromyces
lactis NRRL Y-1140]
Length = 590
Score = 644 bits (1660), Expect = 0.0
Identities = 330/588 (56%), Positives = 410/588 (69%), Gaps = 1/588 (0%)
Frame = +1
Query: 85 AIISVSDKTGLIPLAHGLVSAGLTLIASGGTAKAIRDQGIDVHDVADVTKFPEMLGGRVK 264
AI+SV DKTGL+ LA GL + ++ASGGTAK +R+ G V DV+ +T PEMLGGRVK
Sbjct: 7 AILSVYDKTGLLDLAKGLAENNVRILASGGTAKMVREAGFPVDDVSSITHAPEMLGGRVK 66
Query: 265 TLHPAVHGGILARDTESDRKDLEKHNISFVSVVVCNLYPFKKTVQSKDCSVEEAVENIDI 444
TLHPAVHGGILAR+ ESD KDL++ NI V VVCNLYPFK+TV S+ EAVE IDI
Sbjct: 67 TLHPAVHGGILARNLESDEKDLKEQNIDKVDFVVCNLYPFKETVAKVGVSIPEAVEEIDI 126
Query: 445 GGVTLLRAAAKNHERVSVICDPADYDHIISELKSGGTTRERRQLLALKAFEHTTSYDESI 624
GGVTLLRAAAKNH RV+++ DP DY ++EL+ G + + R LALKAFEHT YD +I
Sbjct: 127 GGVTLLRAAAKNHARVTILSDPKDYPQFLNELQKGEISSDLRNTLALKAFEHTADYDTAI 186
Query: 625 SGFMRRRFAGNGERALPLRYGTNPHQKDDAELYIVEDEMPIKVLNGSPGYINILDGLNGW 804
S F R++++ N + L LRYG NPHQK ++E+P KVL+GSPGYIN+LD LN W
Sbjct: 187 SDFFRKQYSEN-KTQLALRYGANPHQKPAQAFVTQQEELPFKVLSGSPGYINLLDALNSW 245
Query: 805 QLVKELSDATKMPAAASFKHVSPAGAAVGLPLNETEAACCMVSDLPIDTKKPSLXXXXXX 984
LVKELS + +PAAASFKHVSPAGAAVGLPL++ E V+D I+ P L
Sbjct: 246 PLVKELSASLNLPAAASFKHVSPAGAAVGLPLSDVEKQIYFVAD--IENLSP-LACAYAR 302
Query: 985 XXXXXXMSSFGDFIALSEKCDELTAKIINREVSDGVVAPDFDPAALSLLAKKKNGNYCVL 1164
MSSFGD+IALS D TAKII+REVSDGV+AP F+P AL +L KKKNG YC+L
Sbjct: 303 ARGADRMSSFGDWIALSNIVDVPTAKIISREVSDGVIAPGFEPEALEILKKKKNGKYCIL 362
Query: 1165 KINPNYLPSETEERTVFGLRLRQKRNNAVINAETFNNVVGSANELNKQAIDDLIVATIAL 1344
+I+PNY P E R V+G+ L+QKRN+A+IN +F +V +L +QA+ DL VATIAL
Sbjct: 363 QIDPNYTPEALESRQVYGVTLQQKRNDAIINKSSFKEIVSQNKDLPEQAVIDLTVATIAL 422
Query: 1345 KYAQSNSVCFAHRGQVIGMGAGQQSRIHCTRLAGDKAMNWWLRQHPTVLSLPWKNAIKRS 1524
KY QSNSVC+A G V+G+GAGQQSRIHCTRLAGDKA NWWLRQHP VL W +KR
Sbjct: 423 KYTQSNSVCYAKNGMVVGLGAGQQSRIHCTRLAGDKADNWWLRQHPRVLGFKWAKGVKRP 482
Query: 1525 EKSNAIDVLCSGVLGS-EIAIDQWQQYFNEPVEPLAEDDRKQWLSQQTGVVMSSDAFLPF 1701
EKSNAID+ +G + + E +++ F EPL +++K W+S+ T V +SSDAF PF
Sbjct: 483 EKSNAIDLFVTGQIPTEEPEKSEYESKFETIPEPLTAEEKKSWMSKLTNVALSSDAFFPF 542
Query: 1702 RDNVDCAKQFGVSYVAHPGGSVRDDDIKEACDEHGITLIHTGLRLFHH 1845
DNV A + GV Y+A P GSV D + A D + + +RLFHH
Sbjct: 543 PDNVYRAVRSGVKYIAAPSGSVMDKAVFGAADSFDLVYVENPIRLFHH 590
>gi|6323768|ref|NP_013839.1| Enzyme of 'de novo' purine biosynthesis
containing both 5-aminoimidazole-4-carboxamide
ribonucleotide transformylase and inosine monophosphate
cyclohydrolase activities, isozyme of Ade16p; ade16 ade17
mutants require adenine and histidine; Ade17p
[Saccharomyces cerevisiae]
gi|1709915|sp|P38009|PU92_YEAST Bifunctional purine biosynthesis
protein ADE17 [Includes:
Phosphoribosylaminoimidazolecarboxamide formyltransferase
(AICAR transformylase); IMP cyclohydrolase (Inosinicase)
(IMP synthetase) (ATIC)]
gi|1084913|pir||S54489 phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) - yeast (Saccharomyces
cerevisiae)
gi|809579|emb|CAA89269.1| unknown [Saccharomyces cerevisiae]
Length = 592
Score = 644 bits (1660), Expect = 0.0
Identities = 329/596 (55%), Positives = 414/596 (69%), Gaps = 2/596 (0%)
Frame = +1
Query: 64 MTDGKSLAIISVSDKTGLIPLAHGLVSAGLTLIASGGTAKAIRDQGIDVHDVADVTKFPE 243
M + AI+SV DKTGL+ LA GL+ + ++ASGGTA+ IRD G + DV+ +T PE
Sbjct: 1 MANYTKTAILSVYDKTGLLDLARGLIEKNVRILASGGTARMIRDAGFPIEDVSAITHAPE 60
Query: 244 MLGGRVKTLHPAVHGGILARDTESDRKDLEKHNISFVSVVVCNLYPFKKTVQSKDCSVEE 423
MLGGRVKTLHPAVHGGILARD +SD KDL++ +I V VVCNLYPFK+TV ++ E
Sbjct: 61 MLGGRVKTLHPAVHGGILARDIDSDEKDLKEQHIEKVDYVVCNLYPFKETVAKVGVTIPE 120
Query: 424 AVENIDIGGVTLLRAAAKNHERVSVICDPADYDHIISELKSGGT-TRERRQLLALKAFEH 600
AVE IDIGGVTLLRAAAKNH RV+++ DP DY +SEL S G +++ R LALKAFEH
Sbjct: 121 AVEEIDIGGVTLLRAAAKNHARVTILSDPKDYSEFLSELSSNGEISQDLRNRLALKAFEH 180
Query: 601 TTSYDESISGFMRRRFAGNGERALPLRYGTNPHQKDDAELYIVEDEMPIKVLNGSPGYIN 780
T YD +IS F R++++ G+ + LRYG NPHQK +D +P KVL GSPGYIN
Sbjct: 181 TADYDAAISDFFRKQYS-EGQAQITLRYGANPHQKPAQAYVSQQDSLPFKVLCGSPGYIN 239
Query: 781 ILDGLNGWQLVKELSDATKMPAAASFKHVSPAGAAVGLPLNETEAACCMVSDLPIDTKKP 960
+LD LN W LVKELS + +PAAASFKHVSPAGAAVG+PL++ E V+D I+ P
Sbjct: 240 LLDALNSWPLVKELSASLNLPAAASFKHVSPAGAAVGIPLSDVEKQVYFVAD--IENLSP 297
Query: 961 SLXXXXXXXXXXXXMSSFGDFIALSEKCDELTAKIINREVSDGVVAPDFDPAALSLLAKK 1140
L MSSFGD+IALS D TAKII+REVSDGV+AP ++P AL++L+KK
Sbjct: 298 -LACAYARARGADRMSSFGDWIALSNIVDVPTAKIISREVSDGVIAPGYEPEALAILSKK 356
Query: 1141 KNGNYCVLKINPNYLPSETEERTVFGLRLRQKRNNAVINAETFNNVVGSANELNKQAIDD 1320
K G YC+L+I+PNY+P E R V+G+ L QKRN+A+IN TF +V L +QAI D
Sbjct: 357 KGGKYCILQIDPNYVPEAVERRQVYGVTLEQKRNDAIINQSTFKEIVSQNKNLTEQAIID 416
Query: 1321 LIVATIALKYAQSNSVCFAHRGQVIGMGAGQQSRIHCTRLAGDKAMNWWLRQHPTVLSLP 1500
L VATIA+KY QSNSVC+A G V+G+GAGQQSRIHCTRLAGDKA NWW RQHP VL +
Sbjct: 417 LTVATIAIKYTQSNSVCYARNGMVVGLGAGQQSRIHCTRLAGDKADNWWFRQHPRVLEIK 476
Query: 1501 WKNAIKRSEKSNAIDVLCSGVLGS-EIAIDQWQQYFNEPVEPLAEDDRKQWLSQQTGVVM 1677
W +KR EKSNAID+ +G + + E + ++Q F E +P ++RK+WLS+ T V +
Sbjct: 477 WAKGVKRPEKSNAIDLFVTGQIPTEEPELSEYQSKFEEIPKPFTPEERKEWLSKLTNVSL 536
Query: 1678 SSDAFLPFRDNVDCAKQFGVSYVAHPGGSVRDDDIKEACDEHGITLIHTGLRLFHH 1845
SSDAF PF DNV A + GV Y+A P GSV D + A D + + +RLFHH
Sbjct: 537 SSDAFFPFPDNVYRAVKSGVKYIAAPSGSVMDKVVFSAADSFDLVYVENPIRLFHH 592
>gi|50260232|gb|EAL22891.1| hypothetical protein CNBA6600
[Cryptococcus neoformans var. neoformans B-3501A]
Length = 605
Score = 639 bits (1648), Expect = 0.0
Identities = 335/611 (54%), Positives = 425/611 (68%), Gaps = 17/611 (2%)
Frame = +1
Query: 64 MTDGKSLAIISVSDKTGLIPLAHGLVSAGLTLIASGGTAKAIRDQGIDVHDVADVTKFPE 243
M+ +A++SV DKTGL+P A L G L+ SGGTAK IR+ G+++ DV+++TK PE
Sbjct: 1 MSSEAPIALLSVYDKTGLLPFAKSLKELGFRLLGSGGTAKMIREAGMEIEDVSNITKAPE 60
Query: 244 MLGGRVKTLHPAVHGGILARDTESDRKDLEKHNISFVSVVVCNLYPFKKTVQSKDCSVEE 423
MLGGRVKTLHPAVHGGIL+RD SD DL + IS +++VVCNLYPF DC++
Sbjct: 61 MLGGRVKTLHPAVHGGILSRDIPSDLADLATNKISPITLVVCNLYPFVLQTSKPDCTLAG 120
Query: 424 AVENIDIGGVTLLRAAAKNHERVSVICDPADYDHIISELKSGG-TTRERRQLLALKAFEH 600
A+E IDIGGVTLLRAAAKNH RVS+I P+DY+ I++ELK+ G + E ++ LA+KAFE
Sbjct: 121 AIEEIDIGGVTLLRAAAKNHGRVSIISSPSDYETIVAELKAKGEVSAETKRGLAIKAFED 180
Query: 601 TTSYDESISGFMRRRFA------------GNGERALPLRYGTNPHQKDDAELYIVEDEMP 744
T SYDE+IS + R+ +A G G + L LRYG NPHQK A+ ++ + EMP
Sbjct: 181 TKSYDEAISDYFRKVYATPGVEDEMKAGAGVGYQRLGLRYGANPHQKP-AQAFVEQGEMP 239
Query: 745 IKVLNGSPGYINILDGLNGWQLVKELSDATKMPAAASFKHVSPAGAAVGLPLNETEAACC 924
IKVL+GSPGYIN+LD LN W LVKEL+ +PAAASFKHVSPAGAAVGLPL+E A
Sbjct: 240 IKVLSGSPGYINLLDALNSWALVKELAAGLNLPAAASFKHVSPAGAAVGLPLDERAAKVF 299
Query: 925 MVSDLPIDTKKPSLXXXXXXXXXXXXMSSFGDFIALSEKCDELTAKIINREVSDGVVAPD 1104
V DL + L MSSFGDFIALS D TAKII+REVSDGV+AP
Sbjct: 300 GVEDLK---ELSPLACAYARARGADRMSSFGDFIALSHSVDTPTAKIISREVSDGVIAPG 356
Query: 1105 FDPAALSLLAKKKNGNYCVLKINPNYLPSETEERTVFGLRLRQKRNNAVINAETFNNVVG 1284
++P AL +L+KKK G YCVL+++PNY+P E E R V+G+ L+QKRN+ I+ F NVV
Sbjct: 357 YEPEALEILSKKKGGKYCVLQMDPNYVPPEIETRQVYGISLQQKRNDCKIDESLFRNVVT 416
Query: 1285 SANELNKQAIDDLIVATIALKYAQSNSVCFAHRGQVIGMGAGQQSRIHCTRLAGDKAMNW 1464
+ +L K AI DL+VAT+ALKY QSNSVC+A G VIG+GAGQQSRIHCTRLAGDKA NW
Sbjct: 417 ANKDLPKSAITDLVVATLALKYTQSNSVCYALNGTVIGLGAGQQSRIHCTRLAGDKADNW 476
Query: 1465 WLRQHPTVLSLPWKNAIKRSEKSNAIDVLCSG----VLGSEIAIDQWQQYFNEPVEPLAE 1632
WLR HP VL LP+K KR++K+NAID+ +G G E A QW+ F EPL +
Sbjct: 477 WLRHHPRVLELPFKKGTKRADKANAIDLFVTGQAFEAEGGERA--QWESLFETVPEPLTK 534
Query: 1633 DDRKQWLSQQTGVVMSSDAFLPFRDNVDCAKQFGVSYVAHPGGSVRDDDIKEACDEHGIT 1812
++R++ + + TGV +SDAF PF DNV AK+ G +Y+A P GS+ D + +A DE+ +
Sbjct: 535 EEREKHMKELTGVACASDAFFPFPDNVHRAKRSGATYLAAPSGSIMDKECIKAADENNLV 594
Query: 1813 LIHTGLRLFHH 1845
HT LRLFHH
Sbjct: 595 FCHTDLRLFHH 605
>gi|37515243|gb|AAQ91905.1| Hypothetical protein C55F2.1c
[Caenorhabditis elegans]
Length = 393
Score = 639 bits (1648), Expect = 0.0
Identities = 318/331 (96%), Positives = 319/331 (96%)
Frame = +1
Query: 586 KAFEHTTSYDESISGFMRRRFAGNGERALPLRYGTNPHQKDDAELYIVEDEMPIKVLNGS 765
KAFEHTTSYDESISGFMRRRFAGNGERALPLRYGTNPHQKDDAELYIVEDEMPIKVLNGS
Sbjct: 45 KAFEHTTSYDESISGFMRRRFAGNGERALPLRYGTNPHQKDDAELYIVEDEMPIKVLNGS 104
Query: 766 PGYINILDGLNGWQLVKELSDATKMPAAASFKHVSPAGAAVGLPLNETEAACCMVSDLPI 945
PGYINILDGLNGWQLVKELSDATKMPAAASFKHVSPAGAAVGLPLNETEAACCMVSDLPI
Sbjct: 105 PGYINILDGLNGWQLVKELSDATKMPAAASFKHVSPAGAAVGLPLNETEAACCMVSDLPI 164
Query: 946 DTKKPSLXXXXXXXXXXXXMSSFGDFIALSEKCDELTAKIINREVSDGVVAPDFDPAALS 1125
DTKKPSL MSSFGDFIALSEKCDELTAKIINREVSDGVVAPDFDPAALS
Sbjct: 165 DTKKPSLAAAYARARGADRMSSFGDFIALSEKCDELTAKIINREVSDGVVAPDFDPAALS 224
Query: 1126 LLAKKKNGNYCVLKINPNYLPSETEERTVFGLRLRQKRNNAVINAETFNNVVGSANELNK 1305
LLAKKKNGNYCVLKINPNYLPSETEERTVFGLRLRQKRNNAVINAETFNNVVGSANELNK
Sbjct: 225 LLAKKKNGNYCVLKINPNYLPSETEERTVFGLRLRQKRNNAVINAETFNNVVGSANELNK 284
Query: 1306 QAIDDLIVATIALKYAQSNSVCFAHRGQVIGMGAGQQSRIHCTRLAGDKAMNWWLRQHPT 1485
QAIDDLIVATIALKYAQSNSVCFAHRGQVIGMGAGQQSRIHCTRLAGDKAMNWWLRQHPT
Sbjct: 285 QAIDDLIVATIALKYAQSNSVCFAHRGQVIGMGAGQQSRIHCTRLAGDKAMNWWLRQHPT 344
Query: 1486 VLSLPWKNAIKRSEKSNAIDVLCSGVLGSEI 1578
VLSLPWKNAIKRSEKSNAIDVLCSGVLGSE+
Sbjct: 345 VLSLPWKNAIKRSEKSNAIDVLCSGVLGSEV 375