Homology by BLASTX
BLASTX 2.2.4 [Aug-26-2002]
Query= F22E10_5
(3984 letters)
Database: /home/niguts/usr02/tshini/ykclst/db/nr.seq
1,967,186 sequences; 661,712,633 total letters
Score E
Sequences producing significant alignments: (bits) Value
gi|17567269|ref|NP_510128.1| P-GlycoProtein related (146.8 kD) (... 2403 0.0
gi|39587988|emb|CAE57219.1| Hypothetical protein CBG00079 [Caeno... 2321 0.0
gi|39587987|emb|CAE57218.1| Hypothetical protein CBG00078 [Caeno... 1822 0.0
gi|39587990|emb|CAE57221.1| Hypothetical protein CBG00083 [Caeno... 1773 0.0
gi|17567267|ref|NP_510127.1| P-GlycoProtein related (pgp-13) [Ca... 1689 0.0
gi|17567265|ref|NP_510126.1| P-GlycoProtein related (pgp-12) [Ca... 1605 0.0
gi|39587992|emb|CAE57223.1| Hypothetical protein CBG00086 [Caeno... 1602 0.0
gi|17567271|ref|NP_510129.1| P-GlycoProtein related (pgp-15) [Ca... 1266 0.0
gi|5733124|gb|AAD49436.1| P-glycoprotein [Onchocerca volvulus] 935 0.0
gi|39587899|emb|CAE67917.1| Hypothetical protein CBG13514 [Caeno... 867 0.0
gi|17541710|ref|NP_502413.1| P-GlycoProtein related (pgp-1) [Cae... 865 0.0
gi|283551|pir||S27337 multidrug resistance protein A - Caenorhab... 864 0.0
gi|17569145|ref|NP_509902.1| P-GlycoProtein related (pgp-4) [Cae... 862 0.0
gi|39594783|emb|CAE70651.1| Hypothetical protein CBG17356 [Caeno... 860 0.0
gi|39594784|emb|CAE70652.1| Hypothetical protein CBG17357 [Caeno... 846 0.0
gi|17558664|ref|NP_507487.1| P-GlycoProtein related (pgp-9) [Cae... 843 0.0
gi|17569143|ref|NP_509901.1| P-GlycoProtein related (pgp-3) [Cae... 842 0.0
gi|39585393|emb|CAE61715.1| Hypothetical protein CBG05664 [Caeno... 832 0.0
gi|2506118|sp|P08183|MDR1_HUMAN Multidrug resistance protein 1 (... 819 0.0
gi|42741659|ref|NP_000918.2| ATP-binding cassette sub-family B m... 818 0.0
gi|8926217|gb|AAF81747.1| his-tagged-multidrug resistance glycop... 817 0.0
gi|283552|pir||S27338 P-glycoprotein C - Caenorhabditis elegans ... 817 0.0
gi|46394986|gb|AAS91649.1| multidrug resistance protein 1a; P-gl... 817 0.0
gi|46394982|gb|AAS91647.1| multidrug resistance protein 1; P-gly... 816 0.0
gi|25453402|ref|NP_596892.1| ATP-binding cassette, sub-family B ... 816 0.0
gi|2353264|gb|AAB69423.1| P-glycoprotein [Homo sapiens] 816 0.0
gi|307180|gb|AAA59575.1| P-glycoprotein [Homo sapiens] 816 0.0
gi|126924|sp|P21448|MDR1_CRIGR Multidrug resistance protein 1 (P... 815 0.0
gi|22759019|gb|AAN05645.1| multidrug resistance p-glycoprotein [... 815 0.0
gi|2852441|gb|AAC02113.1| multidrug resistance p-glycoprotein [C... 815 0.0
gi|31442763|gb|AAN07780.2| multidrug resistance p-glycoprotein [... 811 0.0
gi|72477|pir||DVHY1C multidrug resistance protein 1 - Chinese ha... 811 0.0
gi|6755048|ref|NP_035206.1| ATP-binding cassette, sub-family B (... 810 0.0
gi|48267183|gb|AAQ63650.3| multi-drug resistance P-glycoprotein ... 810 0.0
gi|46394984|gb|AAS91648.1| multidrug resistance protein; P-glyco... 810 0.0
gi|266517|sp|P21447|MDR3_MOUSE Multidrug resistance protein 3 (P... 809 0.0
gi|22775296|gb|AAN07779.1| multidrug resistance p-glycoprotein [... 809 0.0
gi|25453370|ref|NP_036755.2| P-glycoprotein/multidrug resistance... 808 0.0
gi|126928|sp|P21449|MDR2_CRIGR Multidrug resistance protein 2 (P... 807 0.0
gi|833699|gb|AAA75000.1| multidrug resistance protein >gnl|BL_OR... 807 0.0
gi|1362689|pir||S55692 multidrug resistance protein homolog (mdr... 807 0.0
gi|50732589|ref|XP_418707.1| PREDICTED: similar to ATP-binding c... 806 0.0
gi|25297453|pir||D87789 protein C34G6.4 [imported] - Caenorhabdi... 806 0.0
gi|39595370|emb|CAE60408.1| Hypothetical protein CBG04013 [Caeno... 804 0.0
gi|45382457|ref|NP_990225.1| ABC transporter protein [Gallus gal... 801 0.0
gi|6679297|ref|NP_032856.1| ATP-binding cassette, sub-family B (... 800 0.0
gi|17508505|ref|NP_491707.1| P-GlycoProtein related (pgp-2) [Cae... 798 0.0
gi|2149087|gb|AAB58489.1| multidrug resistance protein-1 [Ovis a... 798 0.0
gi|1170902|sp|P43245|MDR1_RAT Multidrug resistance protein 1 (P-... 797 0.0
gi|6981354|ref|NP_036822.1| ATP-binding cassette, sub-family B (... 792 0.0
gi|4505771|ref|NP_000434.1| ATP-binding cassette, subfamily B, m... 791 0.0
gi|191157|gb|AAA37005.1| p-glycoprotein 786 0.0
gi|126930|sp|P23174|MDR3_CRIGR Multidrug resistance protein 3 (P... 785 0.0
gi|9961250|ref|NP_061337.1| ATP-binding cassette, subfamily B, m... 784 0.0
gi|40644181|emb|CAC86600.1| multidrug resistance protein [Platic... 776 0.0
gi|7511698|pir||T31073 multidrug resistance p-glycoprotein - nem... 762 0.0
gi|9961252|ref|NP_061338.1| ATP-binding cassette, subfamily B, m... 749 0.0
gi|72475|pir||DVMS1A multidrug resistance protein 1a - mouse (fr... 746 0.0
gi|5456701|gb|AAD43626.1| multidrug resistance protein MDR [Emer... 738 0.0
gi|45361353|ref|NP_989254.1| hypothetical protein MGC76216 [Xeno... 735 0.0
gi|49089458|ref|XP_406437.1| hypothetical protein AN2300.2 [Aspe... 734 0.0
gi|27656757|gb|AAO20901.1| Mdr3 [Takifugu rubripes] 734 0.0
gi|39595964|emb|CAE67467.1| Hypothetical protein CBG12969 [Caeno... 730 0.0
gi|6472653|dbj|BAA87071.1| multi-drug resistance related mRNA [F... 723 0.0
gi|22026798|ref|NP_523740.2| CG8523-PA [Drosophila melanogaster]... 722 0.0
gi|2673951|gb|AAB88657.1| multidrug resistance protein 1 [Asperg... 721 0.0
gi|13641444|gb|AAK31736.1| p-glycoprotein [Mucor racemosus] 720 0.0
gi|14030565|gb|AAK52958.1| bile salt export pump [Raja erinacea] 718 0.0
gi|48094917|ref|XP_394305.1| similar to ENSANGP00000021663 [Apis... 718 0.0
gi|27656758|gb|AAO20902.1| Mdr2 [Takifugu rubripes] 718 0.0
gi|15147363|gb|AAG01549.3| multidrug resistance protein MDR [Tri... 717 0.0
gi|11038656|ref|NP_066302.1| ATP-binding cassette, sub-family B,... 709 0.0
gi|31213429|ref|XP_315658.1| ENSANGP00000021663 [Anopheles gambi... 707 0.0
gi|18496818|gb|AAL74250.1| ABC transporter AbcB3 [Dictyostelium ... 707 0.0
gi|7514034|pir||T42228 P-glycoprotein sister - rat >gnl|BL_ORD_I... 704 0.0
gi|13929072|ref|NP_113948.1| ATP-binding cassette, sub-family B ... 704 0.0
gi|12585141|sp|Q9N0V3|AB11_RABIT Bile salt export pump (ATP-bind... 698 0.0
gi|18496816|gb|AAL74249.1| ABC transporter AbcB2 [Dictyostelium ... 698 0.0
gi|40644167|emb|CAC86593.1| sister of P-glycoprotein [Platichthy... 696 0.0
gi|157873|gb|AAA16186.1| P-glycoprotein/multidrug resistance pro... 693 0.0
gi|1079107|pir||A47377 multidrug resistance protein Mdr50 - frui... 693 0.0
gi|50507726|emb|CAA94219.3| Hypothetical protein T21E8.2 [Caenor... 685 0.0
gi|27368859|emb|CAD59587.1| MDR-like ABC transporter [Oryza sati... 679 0.0
gi|17569909|ref|NP_509812.1| P-GlycoProtein related (pgp-7) [Cae... 679 0.0
gi|19032275|dbj|BAB85651.1| multidrug resistance protein 1 homol... 672 0.0
gi|50546639|ref|XP_500789.1| hypothetical protein [Yarrowia lipo... 668 0.0
gi|22535563|dbj|BAC10738.1| putative multidrug resistance protei... 667 0.0
gi|266518|sp|Q00449|MDR4_DROME Multidrug resistance protein homo... 667 0.0
gi|24653245|ref|NP_523724.2| CG3879-PA [Drosophila melanogaster]... 667 0.0
gi|46390486|dbj|BAD15946.1| putative MDR-like ABC transporter [O... 666 0.0
gi|17569907|ref|NP_509813.1| P-GlycoProtein related (pgp-6) [Cae... 665 0.0
gi|50260330|gb|EAL22989.1| hypothetical protein CNBA7570 [Crypto... 664 0.0
gi|24659289|ref|NP_648040.1| CG10226-PA [Drosophila melanogaster... 662 0.0
gi|15226477|ref|NP_182223.1| multidrug resistant (MDR) ABC trans... 662 0.0
gi|39594939|emb|CAE70807.1| Hypothetical protein CBG17569 [Caeno... 660 0.0
gi|49080124|ref|XP_403624.1| hypothetical protein UM06009.1 [Ust... 659 0.0
gi|11346278|pir||T43261 multidrug resistance protein 1 - fungus ... 657 0.0
gi|34894326|ref|NP_908488.1| unnamed protein product [Oryza sati... 655 0.0
gi|34913530|ref|NP_918112.1| putative multidrug resistance prote... 655 0.0
gi|14715462|dbj|BAB62040.1| CjMDR1 [Coptis japonica] 652 0.0
gi|15217776|ref|NP_174115.1| multidrug resistance P-glycoprotein... 651 0.0
gi|27368865|emb|CAD59590.1| MDR-like ABC transporter [Oryza sati... 650 0.0
gi|15217785|ref|NP_171753.1| multidrug resistance P-glycoprotein... 649 0.0
gi|15234323|ref|NP_192092.1| multidrug resistance P-glycoprotein... 647 0.0
gi|17136662|ref|NP_476831.1| CG10181-PA [Drosophila melanogaster... 647 0.0
gi|21464386|gb|AAM51996.1| RE14657p [Drosophila melanogaster] 647 0.0
gi|4204793|gb|AAD10836.1| P-glycoprotein [Solanum tuberosum] 646 0.0
gi|103252|pir||B41249 multidrug resistance protein homolog Mdr65... 645 0.0
gi|15217809|ref|NP_174122.1| multidrug resistance P-glycoprotein... 643 0.0
gi|15234322|ref|NP_192091.1| multidrug resistance P-glycoprotein... 642 0.0
gi|25455873|pir||T52319 P-glycoprotein-like protein pgp3 [import... 641 0.0
gi|24324262|gb|AAN28720.2| MDR-like p-glycoprotein [Arabidopsis ... 639 0.0
gi|15217786|ref|NP_171754.1| multidrug resistance P-glycoprotein... 639 0.0
gi|15228695|ref|NP_191774.1| multidrug resistant (MDR) ABC trans... 638 0.0
gi|15228506|ref|NP_189528.1| multidrug resistance P-glycoprotein... 638 0.0
gi|17550138|ref|NP_509810.1| P-GlycoProtein related (pgp-5) [Cae... 636 e-180
gi|26449438|dbj|BAC41846.1| putative P-glycoprotein [Arabidopsis... 635 e-180
gi|46390962|dbj|BAD16475.1| putative multidrug resistance p-glyc... 632 e-179
gi|27368855|emb|CAD59585.1| MDR-like ABC transporter [Oryza sati... 632 e-179
gi|22328760|ref|NP_193539.2| ABC transporter family protein [Ara... 629 e-178
gi|15229473|ref|NP_189475.1| ABC transporter family protein [Ara... 629 e-178
gi|34913544|ref|NP_918119.1| putative multidrug resistance prote... 629 e-178
gi|25407562|pir||H85202 hypothetical protein AT4g18050 [imported... 627 e-178
gi|15232977|ref|NP_189479.1| P-glycoprotein, putative [Arabidops... 627 e-178
gi|25297456|pir||F86155 probable ABC transporter [imported] - Ar... 627 e-178
gi|38345252|emb|CAD41096.2| OSJNBb0011N17.13 [Oryza sativa (japo... 625 e-177
gi|15228052|ref|NP_181228.1| multidrug resistance P-glycoprotein... 625 e-177
gi|27368849|emb|CAD59582.1| MDR-like ABC transporter [Oryza sati... 621 e-176
gi|7442649|pir||T06165 multidrug resistance protein 1 homolog - ... 621 e-176
gi|22655312|gb|AAM98246.1| putative ABC transporter [Arabidopsis... 619 e-175
gi|9294577|dbj|BAB02858.1| multidrug resistance p-glycoprotein; ... 619 e-175
gi|34911450|ref|NP_917072.1| putative multidrug resistance prote... 619 e-175
gi|38049160|gb|AAR10387.1| P-glycoprotein 1 [Sorghum bicolor] 617 e-175
gi|27368867|emb|CAD59591.1| MDR-like ABC transporter [Oryza sati... 617 e-175
gi|20466380|gb|AAM20507.1| P-glycoprotein-2 [Arabidopsis thaliana] 613 e-174
gi|9294571|dbj|BAB02852.1| multidrug resistance p-glycoprotein; ... 613 e-173
gi|15236067|ref|NP_194326.1| multidrug resistance P-glycoprotein... 612 e-173
gi|45735908|dbj|BAD12940.1| putative P-glycoprotein 1 [Oryza sat... 612 e-173
gi|27368847|emb|CAD59581.1| MDR-like ABC transporter [Oryza sati... 611 e-173
gi|7494503|pir||T30855 multidrug resistance protein 2 - fluke (S... 611 e-173
gi|22331385|ref|NP_683599.1| P-glycoprotein, putative [Arabidops... 610 e-173
gi|25146777|ref|NP_509811.2| P-GlycoProtein related (pgp-8) [Cae... 607 e-172
gi|7511495|pir||T18940 multidrug resistance protein homolog - Ca... 606 e-171
gi|6671365|gb|AAF23176.1| P-glycoprotein [Gossypium hirsutum] 605 e-171
gi|27368869|emb|CAD59592.1| MDR-like ABC transporter [Oryza sati... 600 e-170
gi|27368861|emb|CAD59588.1| MDR-like ABC transporter [Oryza sati... 600 e-170
gi|46129276|ref|XP_388999.1| hypothetical protein FG08823.1 [Gib... 600 e-170
gi|15232978|ref|NP_189480.1| P-glycoprotein, putative [Arabidops... 599 e-169
gi|27368845|emb|CAD59580.1| MDR-like ABC transporter [Oryza sati... 598 e-169
gi|24960750|gb|AAN65444.1| Hypothetical protein [Oryza sativa (j... 598 e-169
gi|27368851|emb|CAD59583.1| MDR-like ABC transporter [Oryza sati... 597 e-169
gi|15220188|ref|NP_172538.1| P-glycoprotein, putative [Arabidops... 596 e-168
gi|7442651|pir||T14805 hypothetical protein F15J5.20 - Arabidops... 594 e-168
gi|15232975|ref|NP_189477.1| ABC transporter family protein [Ara... 594 e-168
gi|21740907|emb|CAD40903.1| OSJNBa0036B21.21 [Oryza sativa (japo... 590 e-167
gi|49089656|ref|XP_406486.1| hypothetical protein AN2349.2 [Aspe... 590 e-166
gi|5456699|gb|AAD43625.1| ATP-binding cassette multidrug transpo... 578 e-163
gi|37695542|gb|AAR00316.1| PGP1; ZMPGP1 [Zea mays] 573 e-161
gi|39594943|emb|CAE70811.1| Hypothetical protein CBG17574 [Caeno... 568 e-160
gi|4521245|dbj|BAA76299.1| LAMDR1 [Leishmania mexicana amazonensis] 561 e-158
gi|4574224|gb|AAD23956.1| multidrug resistance transporter homol... 558 e-157
gi|27368841|emb|CAD59578.1| MDR-like ABC transporter [Oryza sati... 556 e-156
gi|25297460|pir||B86240 protein F20B24.12 [imported] - Arabidops... 554 e-156
gi|49081308|ref|XP_404076.1| hypothetical protein UM06461.1 [Ust... 552 e-155
gi|7442650|pir||JG0166 LaMDR1 protein - Leishmania mexicana amaz... 548 e-154
gi|7508148|pir||T25082 hypothetical protein T21E8.2 - Caenorhabd... 548 e-154
gi|9294508|dbj|BAB02613.1| P-glycoprotein; multi-drug resistance... 543 e-152
gi|33307712|gb|AAQ03033.1| P-glycoprotein [Homo sapiens] 539 e-151
gi|46109604|ref|XP_381860.1| hypothetical protein FG01684.1 [Gib... 537 e-151
gi|7508147|pir||T25083 hypothetical protein T21E8.1 - Caenorhabd... 532 e-149
gi|46125007|ref|XP_387057.1| hypothetical protein FG06881.1 [Gib... 530 e-148
gi|36413607|ref|NP_848654.2| ATP-binding cassette, sub-family B,... 521 e-146
gi|38101651|gb|EAA48581.1| hypothetical protein MG00239.4 [Magna... 502 e-140
gi|16304396|gb|AAL15148.1| multidrug resistance transporter-like... 497 e-139
gi|46401536|dbj|BAD16632.1| LAMDR2 [Leishmania amazonensis] 494 e-138
gi|7522025|pir||T30191 multidrug resistance protein 1 - Aureobas... 492 e-137
gi|49084736|ref|XP_404541.1| hypothetical protein AN0404.2 [Aspe... 491 e-137
gi|50732439|ref|XP_418636.1| PREDICTED: similar to Multidrug res... 490 e-136
gi|46107316|ref|XP_380717.1| hypothetical protein FG00541.1 [Gib... 490 e-136
gi|49097828|ref|XP_410374.1| hypothetical protein AN6237.2 [Aspe... 481 e-134
gi|18033871|gb|AAL57242.1| ATP-binding cassette transporter ABC3... 479 e-133
gi|45775220|gb|AAK83023.2| truncated P-glycoprotein [Rattus norv... 472 e-131
gi|6755046|ref|NP_035205.1| ATP-binding cassette, sub-family B (... 466 e-129
gi|13346110|gb|AAK19598.1| putative ABC transporter [Sterkiella ... 437 e-120
gi|38099353|gb|EAA46710.1| hypothetical protein MG09931.4 [Magna... 419 e-115
gi|422285|pir||S30327 multidrug resistance protein 1 - Entamoeba... 419 e-115
gi|38108326|gb|EAA54363.1| hypothetical protein MG02348.4 [Magna... 419 e-115
gi|12643301|sp|O95342|AB11_HUMAN Bile salt export pump (ATP-bind... 417 e-115
gi|21536378|ref|NP_003733.2| ATP-binding cassette, sub-family B ... 417 e-115
gi|4704820|gb|AAD28285.1| bile salt export pump [Homo sapiens] 416 e-114
gi|18253111|dbj|BAB83959.1| multidrug resistance p-glycoprotein ... 414 e-114
gi|47225422|emb|CAG11905.1| unnamed protein product [Tetraodon n... 412 e-113
gi|39587763|emb|CAE67781.1| Hypothetical protein CBG13356 [Caeno... 411 e-113
gi|17532731|ref|NP_495674.1| P-GlycoProtein related (pgp-11) [Ca... 410 e-112
gi|33299999|emb|CAA88940.3| Hypothetical protein DH11.3 [Caenorh... 410 e-112
gi|422286|pir||S30328 multidrug resistance protein 2 - Entamoeba... 410 e-112
gi|393116|gb|AAA93553.1| P-glycoprotein 5 402 e-110
gi|18033873|gb|AAL57243.1| ATP-binding cassette transporter ABC4... 401 e-110
gi|47218631|emb|CAG04960.1| unnamed protein product [Tetraodon n... 400 e-109
gi|38073917|ref|XP_283101.2| similar to multidrug resistance p-g... 400 e-109
gi|5733401|gb|AAD49563.1| P-glycoprotein-like protein [Onchocerc... 398 e-109
gi|50543630|ref|XP_499981.1| hypothetical protein [Yarrowia lipo... 395 e-108
gi|49092568|ref|XP_407745.1| hypothetical protein AN3608.2 [Aspe... 394 e-107
gi|4587971|gb|AAD25925.1| ABC transporter protein AtrC [Emericel... 393 e-107
gi|47225423|emb|CAG11906.1| unnamed protein product [Tetraodon n... 391 e-107
gi|50556486|ref|XP_505651.1| hypothetical protein [Yarrowia lipo... 391 e-107
gi|45735907|dbj|BAD12939.1| putative P-glycoprotein 1 [Oryza sat... 384 e-104
gi|7493911|pir||T30882 multidrug resistance protein 1 - Aspergil... 383 e-104
gi|34935680|ref|XP_234725.2| similar to P-glycoprotein [Rattus n... 378 e-103
gi|25990364|gb|AAN76500.1| P-glycoprotein [Homo sapiens] 375 e-102
gi|191159|gb|AAA37006.1| P-glycoprotein (pgp1) 375 e-102
gi|19075765|ref|NP_588265.1| leptomycin b resistance protein, ab... 371 e-101
gi|218550|dbj|BAA01537.1| pmd1 protein [Schizosaccharomyces pombe] 371 e-101
gi|15237456|ref|NP_199466.1| ABC transporter family protein [Ara... 369 e-100
gi|72478|pir||DVHY2C multidrug resistance protein 2 - Chinese ha... 368 e-100
gi|46111809|ref|XP_382962.1| hypothetical protein FG02786.1 [Gib... 363 2e-98
gi|50750485|ref|XP_422016.1| PREDICTED: similar to liver bile sa... 361 9e-98
gi|191153|gb|AAA37003.1| p-glycoprotein 358 8e-97
gi|39594940|emb|CAE70808.1| Hypothetical protein CBG17570 [Caeno... 355 5e-96
gi|159363|gb|AAA02977.1| P-glycoprotein 351 9e-95
gi|2360941|gb|AAB69130.1| P-glycoprotein 351 9e-95
gi|7494131|pir||T30804 P-glycoprotein 6 - Entamoeba histolytica ... 345 5e-93
gi|37806003|dbj|BAC99416.1| putative MDR-like ABC transporter [O... 344 1e-92
gi|34910738|ref|NP_916716.1| putative P-glycoprotein [Oryza sati... 340 2e-91
gi|27368839|emb|CAD59577.1| MDR-like ABC transporter [Oryza sati... 340 2e-91
gi|730011|sp|Q06034|MDR1_LEIEN Multidrug resistance protein 1 (P... 338 5e-91
gi|18875456|gb|AAL74251.2| ABC transporter AbcB4 [Dictyostelium ... 338 5e-91
gi|41052996|dbj|BAD07905.1| putative MDR-like ABC transporter [O... 334 1e-89
gi|38098857|gb|AAR11078.1| ATP binding cassette transporter [Lep... 331 8e-89
gi|4768949|gb|AAD29692.1| sister of P-glycoprotein [Fundulus het... 330 2e-88
gi|27368843|emb|CAD59579.1| MDR-like ABC transporter [Oryza sati... 329 3e-88
gi|46114962|ref|XP_383499.1| hypothetical protein FG03323.1 [Gib... 329 4e-88
gi|18496814|gb|AAL74248.1| ABC transporter AbcB1 [Dictyostelium ... 327 1e-87
gi|7498268|pir||T20386 hypothetical protein DH11.3 - Caenorhabdi... 327 1e-87
gi|45735909|dbj|BAD12941.1| putative P-glycoprotein 1 [Oryza sat... 326 2e-87
gi|47900485|gb|AAT39242.1| putative P-glycoprotein [Oryza sativa... 322 5e-86
gi|19698967|gb|AAL91219.1| P-glycoprotein, putative [Arabidopsis... 320 2e-85
gi|32402932|ref|XP_322079.1| hypothetical protein [Neurospora cr... 317 1e-84
gi|34525|emb|CAA29547.1| P-glycoprotein (431 AA) [Homo sapiens] 315 6e-84
gi|10241621|emb|CAC09461.1| putative P-glycoprotein [Oryza sativ... 315 7e-84
gi|31216972|ref|XP_316337.1| ENSANGP00000013796 [Anopheles gambi... 313 2e-83
gi|39583384|emb|CAE66359.1| Hypothetical protein CBG11616 [Caeno... 311 1e-82
gi|22327455|ref|NP_198720.2| ABC transporter (TAP2) [Arabidopsis... 307 2e-81
gi|17565938|ref|NP_506645.1| HAlF transporter, PGP related (haf-... 306 3e-81
gi|7510080|pir||T31617 hypothetical protein Y50E8A.m - Caenorhab... 306 3e-81
gi|1174535|gb|AAA86666.1| ATP-binding cassette protein [Fasciola... 306 3e-81
gi|19335724|gb|AAL85486.1| transporter associated with antigen p... 306 3e-81
gi|10177549|dbj|BAB10828.1| ABC transporter-like protein [Arabid... 305 8e-81
gi|32418014|ref|XP_329485.1| hypothetical protein [Neurospora cr... 305 8e-81
gi|39581765|emb|CAE74138.1| Hypothetical protein CBG21809 [Caeno... 303 2e-80
gi|18496654|gb|AAL74186.1| putative ABC transporter [Triticum mo... 303 3e-80
gi|12278525|gb|AAG49002.1| putative ABC transporter [Hordeum vul... 302 5e-80
gi|18496655|gb|AAL74187.1| putative ABC transporter [Triticum mo... 300 1e-79
gi|15966528|ref|NP_386881.1| PROBABLE ABC TRANSPORTER ATP-BINDIN... 300 1e-79
gi|27368853|emb|CAD59584.1| MDR-like ABC transporter [Oryza sati... 300 2e-79
gi|12278526|gb|AAG49003.1| putative ABC transporter [Hordeum vul... 299 4e-79
gi|21326114|gb|AAM47580.1| putative ABC-transporter-like protein... 298 7e-79
gi|23397593|ref|NP_569844.2| CG3156-PA [Drosophila melanogaster]... 298 9e-79
gi|32966961|gb|AAP92331.1| multixenobiotic resistance protein [C... 298 9e-79
gi|32400322|dbj|BAC78652.1| ABC transporter [Aspergillus oryzae] 296 2e-78
gi|12061244|gb|AAG45492.1| 36I5.4 [Oryza sativa (japonica cultiv... 295 6e-78
gi|22298505|ref|NP_681752.1| ABC transporter ATP-binding protein... 295 8e-78
gi|34906082|ref|NP_914388.1| putative P-glycoprotein [Oryza sati... 294 1e-77
gi|27366635|ref|NP_762162.1| ABC-type multidrug transport system... 293 3e-77
gi|20453064|gb|AAM19777.1| At2g39480/F12L6.14 [Arabidopsis thali... 293 3e-77
gi|15225474|ref|NP_181480.1| ABC transporter family protein [Ara... 293 3e-77
gi|7445902|pir||T13416 hypothetical protein 171D11.2 - fruit fly... 292 5e-77
gi|9992887|gb|AAG11416.1| TagA [Dictyostelium discoideum] 291 7e-77
gi|15800775|ref|NP_286789.1| ATP-binding transport protein; mult... 291 7e-77
gi|24112322|ref|NP_706832.1| ATP-binding transport protein; mult... 291 9e-77
gi|16759854|ref|NP_455471.1| probable transport ATP-binding prot... 291 9e-77
gi|26246941|ref|NP_752981.1| Probable transport ATP-binding prot... 291 9e-77
gi|39937052|ref|NP_949328.1| putative ABC transporter ATP-bindin... 291 1e-76
gi|17543740|ref|NP_502776.1| HAlF transporter, PGP related (haf-... 290 2e-76
gi|17533971|ref|NP_495537.1| HAlF transporter, PGP related (haf-... 290 2e-76
gi|37676347|ref|NP_936743.1| ABC-type multidrug transport system... 290 2e-76
gi|40787796|gb|AAH64930.1| ATP-binding cassette, sub-family B, m... 290 3e-76
gi|49138261|ref|XP_413479.1| hypothetical protein AN9342.2 [Aspe... 289 3e-76
gi|22974777|ref|ZP_00020923.1| hypothetical protein [Chloroflexu... 289 4e-76
gi|39582351|emb|CAE67600.1| Hypothetical protein CBG13145 [Caeno... 289 4e-76
gi|9961244|ref|NP_036221.1| ATP-binding cassette, sub-family B, ... 289 4e-76
gi|50121481|ref|YP_050648.1| lipid a export ATP-binding/permease... 288 6e-76
gi|47212418|emb|CAG12367.1| unnamed protein product [Tetraodon n... 288 7e-76
gi|49474685|ref|YP_032727.1| ABC transporter, ATP-binding protei... 288 1e-75
gi|1743404|emb|CAB05917.1| transport-associated protein [Salmo s... 286 3e-75
gi|49476161|ref|YP_034202.1| ABC transporter, ATP-binding protei... 286 3e-75
gi|15233244|ref|NP_191092.1| ABC transporter family protein [Ara... 286 4e-75
gi|24641565|ref|NP_572810.1| CG1824-PA [Drosophila melanogaster]... 286 4e-75
gi|27753995|ref|NP_083296.2| RIKEN cDNA 4833412N02 [Mus musculus... 285 6e-75
gi|34853987|ref|XP_342615.1| similar to RIKEN cDNA 4833412N02 [R... 285 8e-75
gi|39586807|emb|CAE65850.1| Hypothetical protein CBG10984 [Caeno... 285 8e-75
gi|22959359|ref|ZP_00007012.1| COG1132: ABC-type multidrug trans... 285 8e-75
gi|26339816|dbj|BAC33571.1| unnamed protein product [Mus musculus] 285 8e-75
gi|28900647|ref|NP_800302.1| putative ATP-binding/permease fusio... 284 1e-74
gi|5823084|gb|AAD53033.1| TAP1 protein [Oncorhynchus mykiss] 283 2e-74
gi|12248755|dbj|BAB20265.1| mono ATP-binding cassette protein [H... 283 3e-74
gi|26345292|dbj|BAC36297.1| unnamed protein product [Mus musculus] 283 3e-74
gi|9506367|ref|NP_062425.1| ATP-binding cassette, sub-family B, ... 283 3e-74
gi|21753735|dbj|BAC04392.1| unnamed protein product [Homo sapiens] 282 4e-74
gi|17551158|ref|NP_509205.1| P-GlycoProtein related (pgp-10) [Ca... 282 5e-74
gi|31206493|ref|XP_312209.1| ENSANGP00000002692 [Anopheles gambi... 282 5e-74
gi|15891205|ref|NP_356877.1| AGR_L_2179p [Agrobacterium tumefaci... 282 5e-74
gi|6005804|ref|NP_009119.1| ATP-binding cassette, sub-family B, ... 281 7e-74
gi|13123950|sp|Q9NUT2|ABC8_HUMAN ATP-binding cassette, sub-famil... 281 7e-74
gi|7023646|dbj|BAA92038.1| unnamed protein product [Homo sapiens] 281 1e-73
gi|34851887|ref|XP_341718.1| similar to ABC transporter [Rattus ... 281 1e-73
gi|30698733|ref|NP_177218.3| ABC transporter (TAP1) [Arabidopsis... 281 1e-73
gi|27452581|gb|AAN71739.1| ABCB9-like TAP-family protein [Petrom... 279 3e-73
gi|34496280|ref|NP_900495.1| transport ATP-binding protein msbA ... 278 8e-73
gi|17509565|ref|NP_490739.1| HAlF transporter, PGP related (haf-... 278 8e-73
gi|23502573|ref|NP_698700.1| ABC transporter, ATP binding/permea... 278 1e-72
gi|39579434|emb|CAE74830.1| Hypothetical protein CBG22668 [Caeno... 278 1e-72
gi|16121675|ref|NP_404988.1| probable transport ATP-binding prot... 278 1e-72
gi|45441025|ref|NP_992564.1| probable transport ATP-binding prot... 278 1e-72
gi|23016084|ref|ZP_00055844.1| COG1132: ABC-type multidrug trans... 277 1e-72
gi|45548045|ref|ZP_00188081.1| COG1132: ABC-type multidrug trans... 277 2e-72
gi|48730042|ref|ZP_00263791.1| COG1132: ABC-type multidrug trans... 276 2e-72
gi|17986606|ref|NP_539240.1| PROBABLE TRANSPORT ATP-BINDING PROT... 276 3e-72
gi|50259844|gb|EAL22512.1| hypothetical protein CNBB3900 [Crypto... 276 4e-72
gi|46916508|emb|CAG23273.1| putative ATP-binding/permease fusion... 276 4e-72
gi|24374337|ref|NP_718380.1| ABC transporter, ATP-binding protei... 275 5e-72
gi|23125993|ref|ZP_00107905.1| COG2274: ABC-type bacteriocin/lan... 275 5e-72
gi|1743406|emb|CAB05918.1| transport-associated protein [Salmo s... 275 5e-72
gi|7511165|pir||T32865 hypothetical protein ZK484.2 - Caenorhabd... 275 5e-72
gi|17511077|ref|NP_491754.1| HAlF transporter, PGP related (90.8... 275 5e-72
gi|21622336|emb|CAD36977.1| probable multidrug resistance protei... 274 1e-71
gi|23467052|ref|ZP_00122637.1| COG1132: ABC-type multidrug trans... 273 2e-71
gi|29348795|ref|NP_812298.1| ABC transporter, ATP-binding protei... 273 2e-71
gi|39580953|emb|CAE72923.1| Hypothetical protein CBG20243 [Caeno... 273 2e-71
gi|45916934|ref|ZP_00195995.2| COG1132: ABC-type multidrug trans... 273 2e-71
gi|37525574|ref|NP_928918.1| Probable transport ATP-binding prot... 273 2e-71
gi|15616453|ref|NP_244759.1| ABC transporter (ATP-binding protei... 271 1e-70
gi|5911322|gb|AAD55751.1| transporter associated with antigen pr... 270 2e-70
gi|27381043|ref|NP_772572.1| ABC transporter HlyB/MsbA family [B... 270 3e-70
gi|23469088|ref|ZP_00124423.1| COG1132: ABC-type multidrug trans... 269 4e-70
gi|13473363|ref|NP_104930.1| ABC transporter, ATP-binding protei... 269 4e-70
gi|5911326|gb|AAD55753.1| transporter associated with antigen pr... 269 4e-70
gi|5823088|gb|AAD53035.1| TAP2B protein [Oncorhynchus mykiss] 269 4e-70
gi|29561855|emb|CAD87788.1| SI:dZ262K18.3 (ATP-binding cassette,... 269 5e-70
gi|16127504|ref|NP_422068.1| ABC transporter, HlyB/MsbA family [... 269 5e-70
gi|17229419|ref|NP_485967.1| ABC transporter ATP-binding protein... 268 8e-70
gi|48895639|ref|ZP_00328623.1| COG2274: ABC-type bacteriocin/lan... 268 1e-69
gi|39997358|ref|NP_953309.1| ABC transporter, ATP-binding protei... 268 1e-69
gi|37781028|gb|AAP36720.1| transporter associated with antigen p... 267 1e-69
gi|25406058|pir||C96730 probable ABC transporter F5A18.21 [impor... 267 1e-69
gi|9955966|ref|NP_062571.1| ATP-binding cassette, sub-family B (... 267 1e-69
gi|46135109|ref|ZP_00162400.2| COG2274: ABC-type bacteriocin/lan... 267 2e-69
gi|49077780|ref|XP_402711.1| hypothetical protein UM05096.1 [Ust... 266 2e-69
gi|15596310|ref|NP_249804.1| probable ATP-binding/permease fusio... 266 2e-69
gi|32041123|ref|ZP_00138706.1| COG1132: ABC-type multidrug trans... 266 2e-69
gi|46119497|ref|ZP_00176704.2| COG1132: ABC-type multidrug trans... 266 3e-69
gi|48854058|ref|ZP_00308222.1| COG1132: ABC-type multidrug trans... 266 3e-69
gi|15924856|ref|NP_372390.1| ABC transporter homolog [Staphyloco... 266 4e-69
gi|23129118|ref|ZP_00110951.1| COG1132: ABC-type multidrug trans... 265 5e-69
gi|34906862|ref|NP_914778.1| putative ABC transporter [Oryza sat... 265 5e-69
gi|48844191|ref|ZP_00298519.1| COG1132: ABC-type multidrug trans... 265 7e-69
gi|50877523|emb|CAG37363.1| related to ABC-transporter, ATP-bind... 265 7e-69
gi|21242281|ref|NP_641863.1| ABC transporter ATP-binding protein... 264 1e-68
gi|39933996|ref|NP_946272.1| ABC transporter, ATP-binding protei... 264 1e-68
gi|33636348|dbj|BAC81752.1| hydrophobic compound transport facto... 264 1e-68
gi|16264301|ref|NP_437093.1| putative lipid A + LPS core exporti... 264 1e-68
gi|37521898|ref|NP_925275.1| HlyB/MsbA family ABC transporter [G... 264 1e-68
gi|16330857|ref|NP_441585.1| HlyB family [Synechocystis sp. PCC ... 264 1e-68
gi|18124158|gb|AAL59848.1| ATP-binding cassette protein 3 [Crypt... 264 1e-68
gi|32399046|emb|CAD98286.1| ATP-binding cassette transporter [Cr... 264 1e-68
gi|48833973|ref|ZP_00290989.1| COG1132: ABC-type multidrug trans... 263 2e-68
gi|18124194|gb|AAL59859.1| transporter associated with antigen p... 263 2e-68
gi|47077792|dbj|BAD18770.1| unnamed protein product [Homo sapiens] 263 3e-68
gi|21230937|ref|NP_636854.1| ABC transporter ATP-binding protein... 263 3e-68
gi|46913988|emb|CAG20770.1| putative transport ATP-binding prote... 262 4e-68
gi|26006275|dbj|BAC41480.1| mKIAA1520 protein [Mus musculus] 262 4e-68
gi|22095457|sp|Q9JJ59|ABC9_MOUSE ATP-binding cassette, sub-famil... 262 4e-68
gi|48765071|ref|ZP_00269622.1| COG5265: ABC-type transport syste... 262 4e-68
gi|11560034|ref|NP_071574.1| TAP-like ABC transporter [Rattus no... 262 6e-68
gi|9845230|ref|NP_063928.1| ATP-binding cassette, sub-family B, ... 262 6e-68
gi|39992420|gb|AAH64384.1| ABCB9 protein [Homo sapiens] 262 6e-68
gi|50551833|ref|XP_503391.1| hypothetical protein [Yarrowia lipo... 262 6e-68
gi|27376619|ref|NP_768148.1| HlyB/MsbA family ABC transporter [B... 262 6e-68
gi|46133688|ref|ZP_00157567.2| COG1132: ABC-type multidrug trans... 262 6e-68
gi|22995060|ref|ZP_00039543.1| COG1132: ABC-type multidrug trans... 261 7e-68
gi|27381404|ref|NP_772933.1| HlyB/MsbA family ABC transporter [B... 261 7e-68
gi|17232691|ref|NP_489239.1| ATP-binding protein of ABC transpor... 261 7e-68
gi|26988843|ref|NP_744268.1| ABC efflux transporter, permease/AT... 261 1e-67
gi|32563749|ref|NP_871812.1| HAlF transporter, PGP related (haf-... 261 1e-67
gi|28869225|ref|NP_791844.1| ABC transporter, ATP-binding/permea... 261 1e-67
gi|22997178|ref|ZP_00041414.1| COG1132: ABC-type multidrug trans... 261 1e-67
gi|15602726|ref|NP_245798.1| MsbA [Pasteurella multocida Pm70] >... 261 1e-67
gi|17228136|ref|NP_484684.1| ATP-binding protein of ABC transpor... 261 1e-67
gi|16272034|ref|NP_438233.1| ABC transporter ATP-binding protein... 260 2e-67
gi|2119779|pir||S50217 multidrug resistance protein 3 - rat (fra... 260 2e-67
gi|30248923|ref|NP_840993.1| ABC transporter, fused permease and... 260 2e-67
gi|8176565|dbj|BAA96370.1| ABC protein [Physarum polycephalum] 260 2e-67
gi|15963913|ref|NP_384266.1| PUTATIVE ATP-BINDING ABC TRANSPORTE... 259 3e-67
gi|15641880|ref|NP_231512.1| transport ATP-binding protein MsbA ... 259 3e-67
gi|23098861|ref|NP_692327.1| ABC transporter ATP-binding protein... 259 4e-67
gi|34541348|ref|NP_905827.1| ABC transporter, ATP-binding protei... 259 5e-67
gi|29654183|ref|NP_819875.1| ABC transporter, ATP-binding/permea... 259 5e-67
gi|45506769|ref|ZP_00159120.1| COG1132: ABC-type multidrug trans... 259 5e-67
gi|46113651|ref|ZP_00183228.2| COG1132: ABC-type multidrug trans... 258 6e-67
gi|23500772|ref|NP_700212.1| ABC transporter, ATP-binding/permea... 258 6e-67
gi|15890388|ref|NP_356060.1| AGR_L_552p [Agrobacterium tumefacie... 258 6e-67
gi|17988594|ref|NP_541227.1| ABC TRANSPORTER ATP-BINDING PROTEIN... 258 8e-67
gi|42521794|ref|NP_967174.1| ABC transporter, nucleotide binding... 258 8e-67
gi|30249744|ref|NP_841814.1| ABC transporter, fused permease and... 258 8e-67
gi|2673955|gb|AAB88659.1| multidrug resistance protein 2 [Asperg... 258 1e-66
gi|32491003|ref|NP_871257.1| msbA [Wigglesworthia glossinidia en... 258 1e-66
gi|47217174|emb|CAG11010.1| unnamed protein product [Tetraodon n... 258 1e-66
gi|28199828|ref|NP_780142.1| ABC transporter ATP-binding protein... 258 1e-66
gi|37680540|ref|NP_935149.1| transport ATP-binding protein MsbA ... 258 1e-66
gi|16519755|ref|NP_443875.1| Y4gM [Rhizobium sp. NGR234] >gnl|BL... 257 1e-66
gi|27365418|ref|NP_760946.1| Transport ATP-binding protein MsbA ... 257 1e-66
gi|27452473|gb|AAN71740.1| ABCB9-like TAP-family protein [Petrom... 257 1e-66
gi|15839171|ref|NP_299859.1| ABC transporter ATP-binding protein... 257 2e-66
gi|37521765|ref|NP_925142.1| HlyB/MsbA family ABC transporter [G... 257 2e-66
gi|49474872|ref|YP_032913.1| ABC transporter, ATP-binding protei... 257 2e-66
gi|48771097|ref|ZP_00275440.1| COG1132: ABC-type multidrug trans... 256 2e-66
gi|48892154|ref|ZP_00325566.1| COG1132: ABC-type multidrug trans... 256 3e-66
gi|2147880|pir||I48120 P-glycoprotein - Chinese hamster (fragmen... 256 4e-66
gi|47575345|ref|ZP_00245380.1| COG1132: ABC-type multidrug trans... 256 4e-66
gi|29376153|ref|NP_815307.1| ABC transporter, ATP-binding/permea... 255 7e-66
gi|15613689|ref|NP_241992.1| ABC transporter (ATP-binding protei... 254 9e-66
gi|49071168|ref|XP_399873.1| hypothetical protein UM02258.1 [Ust... 254 9e-66
gi|48850584|ref|ZP_00304826.1| COG1132: ABC-type multidrug trans... 254 1e-65
gi|2492605|sp|P97998|MDL1_CANAL ATP-dependent permease MDL1 >gnl... 254 2e-65
gi|28897756|ref|NP_797361.1| transport ATP-binding protein MsbA ... 254 2e-65
gi|4321799|gb|AAD15830.1| TAP2 protein [Xenopus laevis] 254 2e-65
gi|15894891|ref|NP_348240.1| ABC-type multidrug/protein/lipid tr... 253 2e-65
gi|46440040|gb|EAK99351.1| hypothetical protein CaO19.2615 [Cand... 253 2e-65
gi|23104911|ref|ZP_00091371.1| COG1132: ABC-type multidrug trans... 253 2e-65
gi|37520636|ref|NP_924013.1| HlyB/MsbA family ABC transporter [G... 253 2e-65
gi|47092244|ref|ZP_00230036.1| ABC transporter, ATP-binding/perm... 253 3e-65
gi|46906348|ref|YP_012737.1| ABC transporter, ATP-binding/permea... 253 3e-65
gi|31194451|ref|XP_306173.1| ENSANGP00000015516 [Anopheles gambi... 253 3e-65
gi|23124320|ref|ZP_00106317.1| COG2274: ABC-type bacteriocin/lan... 253 3e-65
gi|23102360|ref|ZP_00088871.1| COG5265: ABC-type transport syste... 252 4e-65
gi|16799233|ref|NP_469501.1| similar to ABC transporter, ATP-bin... 252 4e-65
gi|17230327|ref|NP_486875.1| ATP-binding protein; heterocyst dif... 252 4e-65
gi|2625135|gb|AAC32400.1| heterocyst differentiation protein [No... 252 4e-65
gi|33862350|ref|NP_893910.1| ABC transporter, multi drug efflux ... 252 6e-65
gi|50423501|ref|XP_460333.1| unnamed protein product [Debaryomyc... 252 6e-65
gi|1743408|emb|CAB05919.1| transport-associated protein [Salmo s... 252 6e-65
gi|16802156|ref|NP_463641.1| similar to ABC transporter, ATP-bin... 252 6e-65
gi|49473726|ref|YP_031768.1| ABC transporter, ATP-binding protei... 252 6e-65
gi|17230168|ref|NP_486716.1| toxin secretion ABC transporter ATP... 252 6e-65
gi|42779663|ref|NP_976910.1| ABC transporter, ATP-binding/permea... 251 8e-65
gi|17228079|ref|NP_484627.1| ATP-binding protein of ABC transpor... 251 1e-64
gi|36958580|gb|AAQ87048.1| ABC Transporter, ATP-binding protein,... 251 1e-64
gi|12325039|gb|AAG52466.1| putative ABC transporter; 73228-76244... 251 1e-64
gi|47220348|emb|CAF98447.1| unnamed protein product [Tetraodon n... 251 1e-64
gi|311095|gb|AAA20682.1| Mdl2p 251 1e-64
gi|33519838|ref|NP_878670.1| probable transport ATP-binding prot... 251 1e-64
gi|2506122|sp|P33311|MDL2_YEAST ATP-dependent permease MDL2 >gnl... 250 2e-64
gi|37362699|ref|NP_015053.2| ATP-binding cassette (ABC) transpor... 250 2e-64
gi|18478983|dbj|BAB84549.1| ABCB3 [Oryzias latipes] 250 2e-64
gi|46315181|ref|ZP_00215764.1| COG5265: ABC-type transport syste... 250 2e-64
gi|16124560|ref|NP_419124.1| ABC transporter, HlyB/MsbA family [... 250 2e-64
gi|47573606|ref|ZP_00243644.1| COG1132: ABC-type multidrug trans... 249 3e-64
gi|19112543|ref|NP_595751.1| putative permease [Schizosaccharomy... 249 3e-64
gi|49481736|ref|YP_034789.1| ABC transporter ATP-binding and per... 249 3e-64
gi|27468468|ref|NP_765105.1| ABC transporter (ATP-binding protei... 249 4e-64
gi|33152665|ref|NP_874018.1| ABC transporter ATP-binding protein... 249 4e-64
gi|45916645|ref|ZP_00197576.1| COG1132: ABC-type multidrug trans... 249 5e-64
gi|23098355|ref|NP_691821.1| ABC transporter ATP-binding protein... 249 5e-64
gi|2147879|pir||I48119 P-glycoprotein - Chinese hamster (fragmen... 249 5e-64
gi|30519701|emb|CAD90041.1| putative ATP-binding cassette transp... 249 5e-64
gi|45512238|ref|ZP_00163805.1| COG1132: ABC-type multidrug trans... 248 6e-64
gi|23100898|ref|NP_694365.1| ABC transporter ATP-binding protein... 248 8e-64
gi|47572829|ref|ZP_00242870.1| COG1132: ABC-type multidrug trans... 248 8e-64
gi|30260686|ref|NP_843063.1| ABC transporter, ATP-binding/permea... 248 1e-63
gi|15643057|ref|NP_228100.1| ABC transporter, ATP-binding protei... 248 1e-63
gi|41723459|ref|ZP_00150386.1| COG1132: ABC-type multidrug trans... 248 1e-63
gi|32487252|emb|CAD91219.1| putative ABC transporter, Dbv24 [Non... 247 1e-63
gi|21398472|ref|NP_654457.1| ABC_membrane, ABC transporter trans... 247 1e-63
gi|16330165|ref|NP_440893.1| ABC transporter [Synechocystis sp. ... 247 2e-63
gi|50306267|ref|XP_453105.1| unnamed protein product [Kluyveromy... 247 2e-63
gi|18157529|dbj|BAB83844.1| TAP2~partially supported by GENSCAN ... 247 2e-63
gi|4156146|gb|AAD05023.1| unknown [Homo sapiens] 246 2e-63
gi|16077935|ref|NP_388749.1| ygaD [Bacillus subtilis subsp. subt... 246 2e-63
gi|48858770|ref|ZP_00312716.1| COG1132: ABC-type multidrug trans... 246 2e-63
gi|23475242|ref|ZP_00130531.1| COG1132: ABC-type multidrug trans... 246 2e-63
gi|23127899|ref|ZP_00109758.1| COG1132: ABC-type multidrug trans... 246 2e-63
gi|34497639|ref|NP_901854.1| probable ABC transport protein, msb... 246 2e-63
gi|30020094|ref|NP_831725.1| Multidrug resistance ABC transporte... 246 3e-63
gi|18978026|ref|NP_579383.1| hypothetical ABC transporter [Pyroc... 246 3e-63
gi|42781108|ref|NP_978355.1| ABC transporter, ATP-binding/permea... 246 3e-63
gi|7522112|pir||T31077 probable ABC-transporter TycD - Brevibaci... 246 3e-63
gi|50256224|gb|EAL18951.1| hypothetical protein CNBI2120 [Crypto... 246 3e-63
gi|23098860|ref|NP_692326.1| ABC transporter ATP-binding protein... 246 3e-63
gi|42527766|ref|NP_972864.1| ABC transporter, ATP-binding/permea... 246 4e-63
gi|46193446|ref|ZP_00004687.2| COG5265: ABC-type transport syste... 246 4e-63
gi|20804168|emb|CAD31371.1| PROBABLE SACCHARIDE EXPORTING ABC TR... 246 4e-63
gi|45548289|ref|ZP_00188323.1| COG1132: ABC-type multidrug trans... 245 5e-63
gi|22971761|ref|ZP_00018689.1| hypothetical protein [Chloroflexu... 245 5e-63
gi|39580004|emb|CAE56320.1| Hypothetical protein CBG23985 [Caeno... 245 5e-63
gi|50284785|ref|XP_444820.1| unnamed protein product [Candida gl... 245 5e-63
gi|48784303|ref|ZP_00280669.1| COG1132: ABC-type multidrug trans... 245 5e-63
gi|15807369|ref|NP_296100.1| ABC transporter, ATP-binding protei... 245 5e-63
gi|46187441|ref|ZP_00205348.1| COG2274: ABC-type bacteriocin/lan... 245 5e-63
gi|295584|gb|AAA20681.1| Mdl1p 245 7e-63
gi|48786594|ref|ZP_00282728.1| COG5265: ABC-type transport syste... 245 7e-63
>gi|17567269|ref|NP_510128.1| P-GlycoProtein related (146.8 kD)
(pgp-14) [Caenorhabditis elegans]
gi|7499665|pir||T21268 hypothetical protein F22E10.3 - Caenorhabditis
elegans
gi|3876293|emb|CAA91801.1| Hypothetical protein F22E10.3
[Caenorhabditis elegans]
gi|40764042|gb|AAR89639.1| P-glycoprotein related (146.8 kD) (pgp-14)
[Caenorhabditis elegans]
Length = 1327
Score = 2403 bits (6228), Expect = 0.0
Identities = 1239/1327 (93%), Positives = 1239/1327 (93%)
Frame = -1
Query: 3984 MAPKDDPDNRGFDDQRRPSQRSTVLAIPALAVNDPKSDPKIASDLPANYVDDDDDAPKMY 3805
MAPKDDPDNRGFDDQRRPSQRSTVLAIPALAVNDPKSDPKIASDLPANYVDDDDDAPKMY
Sbjct: 1 MAPKDDPDNRGFDDQRRPSQRSTVLAIPALAVNDPKSDPKIASDLPANYVDDDDDAPKMY 60
Query: 3804 TPSLLEKILNYALCRGDIANQQLEAQPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQP 3625
TPSLLEKILNYALCRGDIANQQLEAQPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQP
Sbjct: 61 TPSLLEKILNYALCRGDIANQQLEAQPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQP 120
Query: 3624 ILALVSGRVTNALLVYPPTSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVM 3445
ILALVSGRVTNALLVYPPTSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVM
Sbjct: 121 ILALVSGRVTNALLVYPPTSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVM 180
Query: 3444 AQMRHRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAI 3265
AQMRHRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAI
Sbjct: 181 AQMRHRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAI 240
Query: 3264 VVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTV 3085
VVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTV
Sbjct: 241 VVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTV 300
Query: 3084 QAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVG 2905
QAFNGQEEMVGRYEAELEKGRKFAVWK GCGMLYGAYLLKVG
Sbjct: 301 QAFNGQEEMVGRYEAELEKGRKFAVWKGFWSGFFGGLFFFWLFSFLGCGMLYGAYLLKVG 360
Query: 2904 IITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGK 2725
IITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGK
Sbjct: 361 IITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGK 420
Query: 2724 RLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRL 2545
RLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRL
Sbjct: 421 RLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRL 480
Query: 2544 YEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEV 2365
YEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEV
Sbjct: 481 YEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEV 540
Query: 2364 CKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDA 2185
CKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDA
Sbjct: 541 CKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDA 600
Query: 2184 QSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYF 2005
QSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYF
Sbjct: 601 QSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYF 660
Query: 2004 DLVKAQQFKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGS 1825
DLVKAQQFKADP EIDLDDT SEAFRRGNSLNDSFSGS
Sbjct: 661 DLVKAQQFKADPEATEEFEEEEIDLDDTSRSSRRSSMTSARSGSEAFRRGNSLNDSFSGS 720
Query: 1824 KRSXXXXXXXXXXXXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELP 1645
KRS EDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELP
Sbjct: 721 KRSAQADAENSAFAANEAAIMAEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELP 780
Query: 1644 ALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSM 1465
ALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSM
Sbjct: 781 ALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSM 840
Query: 1464 RFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXX 1285
RFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQV
Sbjct: 841 RFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVIYALAAIIAN 900
Query: 1284 XXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQNDDAGRIAIEIIENVKTI 1105
IYCWQ LAFVMIGLAYKISLMNVEQIQNDDAGRIAIEIIENVKTI
Sbjct: 901 IAIAFIYCWQIGILGTSLILLLAFVMIGLAYKISLMNVEQIQNDDAGRIAIEIIENVKTI 960
Query: 1104 QLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQG 925
QLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQG
Sbjct: 961 QLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQG 1020
Query: 924 DKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLMEGDRP 745
DKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLMEGDRP
Sbjct: 1021 DKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLMEGDRP 1080
Query: 744 EIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDV 565
EIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDV
Sbjct: 1081 EIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDV 1140
Query: 564 TGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGLKDVPLEKINQALEL 385
TGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGLKDVPLEKINQALEL
Sbjct: 1141 TGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGLKDVPLEKINQALEL 1200
Query: 384 ANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESE 205
ANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESE
Sbjct: 1201 ANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESE 1260
Query: 204 RAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLI 25
RAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLI
Sbjct: 1261 RAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLI 1320
Query: 24 KKQDLAV 4
KKQDLAV
Sbjct: 1321 KKQDLAV 1327
>gi|39587988|emb|CAE57219.1| Hypothetical protein CBG00079
[Caenorhabditis briggsae]
Length = 1327
Score = 2321 bits (6016), Expect = 0.0
Identities = 1185/1327 (89%), Positives = 1219/1327 (91%)
Frame = -1
Query: 3984 MAPKDDPDNRGFDDQRRPSQRSTVLAIPALAVNDPKSDPKIASDLPANYVDDDDDAPKMY 3805
MAPKDDPDNRGFDDQRRPSQRSTVLAIPALAVNDPK+DPKIASDLPANYVDDDDDAPK+Y
Sbjct: 1 MAPKDDPDNRGFDDQRRPSQRSTVLAIPALAVNDPKADPKIASDLPANYVDDDDDAPKLY 60
Query: 3804 TPSLLEKILNYALCRGDIANQQLEAQPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQP 3625
TPSL EKILNY LCRGDIANQQLEAQPVSIPGLFRYGK+FDYLLLFIGTICAIISGVSQP
Sbjct: 61 TPSLFEKILNYLLCRGDIANQQLEAQPVSIPGLFRYGKRFDYLLLFIGTICAIISGVSQP 120
Query: 3624 ILALVSGRVTNALLVYPPTSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVM 3445
I+ALVSGRVTNALLVYPPTSKQFRNKANENVYIFLGIGIFISITN+IQYMCFQHCC+RVM
Sbjct: 121 IMALVSGRVTNALLVYPPTSKQFRNKANENVYIFLGIGIFISITNWIQYMCFQHCCSRVM 180
Query: 3444 AQMRHRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAI 3265
AQMRHRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAI
Sbjct: 181 AQMRHRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAI 240
Query: 3264 VVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTV 3085
VVAYIYEWRLASMMLGVAP CCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTV
Sbjct: 241 VVAYIYEWRLASMMLGVAPVCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTV 300
Query: 3084 QAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVG 2905
QAFNGQEEMVGRY+ ELEKGR+FAVWK G GMLYGAYLLKVG
Sbjct: 301 QAFNGQEEMVGRYQTELEKGRRFAVWKGFWSGFFGGLFFLCLFSFLGTGMLYGAYLLKVG 360
Query: 2904 IITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGK 2725
II +PGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAA+IYQTIDRVPKIDPYSKAGK
Sbjct: 361 IIGSPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAATIYQTIDRVPKIDPYSKAGK 420
Query: 2724 RLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRL 2545
RL NVVGRVKFENVHFRYPSRK+AKILNGLNL VEPGTSVALVGHSGCGKSTSVGLLTRL
Sbjct: 421 RLPNVVGRVKFENVHFRYPSRKEAKILNGLNLTVEPGTSVALVGHSGCGKSTSVGLLTRL 480
Query: 2544 YEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEV 2365
YEPEAGNVTIDGTDVRELNI+WLRN VGIVQQEPILFNDTIHNNLLIGNPG+TRE MIEV
Sbjct: 481 YEPEAGNVTIDGTDVRELNIDWLRNVVGIVQQEPILFNDTIHNNLLIGNPGATREKMIEV 540
Query: 2364 CKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDA 2185
CKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPK+LLLDEATSALDA
Sbjct: 541 CKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKILLLDEATSALDA 600
Query: 2184 QSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYF 2005
QSES+VQSALNNA+KGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELV LGGRYF
Sbjct: 601 QSESVVQSALNNAAKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVHLGGRYF 660
Query: 2004 DLVKAQQFKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGS 1825
DLVKAQQFKADP EIDLDD SEAF+RGNSLNDSFSGS
Sbjct: 661 DLVKAQQFKADPEATEEFEEEEIDLDDNSRSSRRSSMTSARSGSEAFQRGNSLNDSFSGS 720
Query: 1824 KRSXXXXXXXXXXXXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELP 1645
+RS +DGQITAGYLDIFKNAKGNY+YMFLGTVFALIRGLELP
Sbjct: 721 RRSARADAENDAFAAHEAEVMAQDGQITAGYLDIFKNAKGNYIYMFLGTVFALIRGLELP 780
Query: 1644 ALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSM 1465
ALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVW SQ+ASSVLFA+VSENLS+
Sbjct: 781 ALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWISQVASSVLFAIVSENLSL 840
Query: 1464 RFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXX 1285
RFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQV
Sbjct: 841 RFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVIYALAAIIAN 900
Query: 1284 XXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQNDDAGRIAIEIIENVKTI 1105
IYCWQ LAFVMIGLAYKISLMN+EQI+ND+AGR AIEIIENVKTI
Sbjct: 901 IVIAFIYCWQVAILGTSLILLLAFVMIGLAYKISLMNIEQIKNDEAGRTAIEIIENVKTI 960
Query: 1104 QLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQG 925
QLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYS+TQSFMYFMMCFTYAVGIR+IY G
Sbjct: 961 QLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSITQSFMYFMMCFTYAVGIRVIYDG 1020
Query: 924 DKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLMEGDRP 745
DKSSD TFKGII+MMLGAVAVMNSAQYFPEFVKAKTAAG+LFNIIYRKPRTGDLMEGDRP
Sbjct: 1021 DKSSDVTFKGIISMMLGAVAVMNSAQYFPEFVKAKTAAGLLFNIIYRKPRTGDLMEGDRP 1080
Query: 744 EIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDV 565
EIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDV
Sbjct: 1081 EIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDV 1140
Query: 564 TGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGLKDVPLEKINQALEL 385
TGG LRIDGQDIR LSL+HLRTQMALVGQEPRLFAG+IRENVCLGLKDVPLEKIN+ALEL
Sbjct: 1141 TGGVLRIDGQDIRNLSLYHLRTQMALVGQEPRLFAGSIRENVCLGLKDVPLEKINKALEL 1200
Query: 384 ANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESE 205
ANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESE
Sbjct: 1201 ANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESE 1260
Query: 204 RAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLI 25
RAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNH QLM +KGRYYKLI
Sbjct: 1261 RAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHAQLMQKKGRYYKLI 1320
Query: 24 KKQDLAV 4
KKQDLAV
Sbjct: 1321 KKQDLAV 1327
>gi|39587987|emb|CAE57218.1| Hypothetical protein CBG00078
[Caenorhabditis briggsae]
Length = 1282
Score = 1822 bits (4720), Expect = 0.0
Identities = 952/1336 (71%), Positives = 1063/1336 (79%), Gaps = 9/1336 (0%)
Frame = -1
Query: 3984 MAPKDDPDNRGFDDQRRPSQRSTVLAIPALAVNDPKSDPKIASDLPANYVDDDDDAPKMY 3805
M P DP G ++ + S+RST+ A PALAV++PK + P ++DDD+ K Y
Sbjct: 1 MFPVADPPRAGPENTGKISRRSTIRAAPALAVSEPKP-----TSAPIEFIDDDE-IRKDY 54
Query: 3804 TPSLLEKILNYALCRGDIANQQLEAQPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQP 3625
PS ++ ++Y LCRGD+A Q E++PVSI GLFRYGK FD+ LLFIG
Sbjct: 55 QPSCFDRFVDYILCRGDVAKQTYESRPVSIFGLFRYGKAFDHFLLFIGI----------- 103
Query: 3624 ILALVSGRVTNALLVYPPTSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVM 3445
I A++SG + P YMCFQHCC+R+M
Sbjct: 104 ICAIISG-------ISQP------------------------------YMCFQHCCSRIM 126
Query: 3444 AQMRHRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAI 3265
AQMRHR+VYSVLRQNAGWFDKNHSGTI TKLNDSMERIREGIGDKLGVL+RG AML+A+I
Sbjct: 127 AQMRHRYVYSVLRQNAGWFDKNHSGTIATKLNDSMERIREGIGDKLGVLIRGVAMLLASI 186
Query: 3264 VVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTV 3085
VVAYIYEWRLA MMLGVAPTC CMSL+ARQMT+TT+KEL GV KAGSIAEESLMGVRTV
Sbjct: 187 VVAYIYEWRLACMMLGVAPTCVGCMSLMARQMTATTVKELGGVEKAGSIAEESLMGVRTV 246
Query: 3084 QAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVG 2905
QAFNGQEEMV RY EL KGRKFA+WK GCG LYGAYLLK+G
Sbjct: 247 QAFNGQEEMVERYRVELNKGRKFAIWKGFWSGLYGGLFFFWLFAFQGCGFLYGAYLLKIG 306
Query: 2904 IITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGK 2725
IIT+PGDVFI+VM+MLLG+YFLGLISPH+MVLLNARV+AASIY+TI+RVPKIDPYSK G+
Sbjct: 307 IITSPGDVFIIVMAMLLGSYFLGLISPHLMVLLNARVAAASIYETIERVPKIDPYSKKGR 366
Query: 2724 RLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRL 2545
L V+GRVKFENVHFRYP+RKDAKILNGLNL +EPGTSVALVGHSGCGKSTSVGLLTRL
Sbjct: 367 FLDKVIGRVKFENVHFRYPTRKDAKILNGLNLTIEPGTSVALVGHSGCGKSTSVGLLTRL 426
Query: 2544 YEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEV 2365
YEPE GNVTIDGTDVRELNI++LRN VGIVQQEPILFNDTIHNNLL+GNP + RE MIEV
Sbjct: 427 YEPETGNVTIDGTDVRELNIDYLRNVVGIVQQEPILFNDTIHNNLLLGNPNAKREKMIEV 486
Query: 2364 CKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDA 2185
CKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDA
Sbjct: 487 CKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDA 546
Query: 2184 QSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYF 2005
QSES+VQSALNNASKGRTTIMIAHRLSTIREAD IVFFEKGVIVEAGNH ELVRL GRY+
Sbjct: 547 QSESVVQSALNNASKGRTTIMIAHRLSTIREADMIVFFEKGVIVEAGNHAELVRLEGRYY 606
Query: 2004 DLVKAQQFKAD--PXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXX------SEAFRRGNS 1849
DLVKAQ FK D P +IDL + +EAFRRG
Sbjct: 607 DLVKAQAFKPDDNPISQYDEIAEDIDLGPSATAIHSRQSSFTSSIRSRISGAEAFRRGTL 666
Query: 1848 LNDSFSGSKRSXXXXXXXXXXXXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFA 1669
DSF+G + S +DGQI+AG+LDIFKNA GNY M LG V
Sbjct: 667 GADSFAGGRSSARADAENAAFAEEVAKVMEQDGQISAGFLDIFKNAHGNYTVMLLGFVTG 726
Query: 1668 LIRGLELPALALIFGWVFEGFTFVPY-GGRMMHRMAMAVIAFASVGVGVWFSQLASSVLF 1492
LIRGLEL A AL+FGWVFEGF ++ G+MMHRMAMAVIA+ G G + SQ SSV F
Sbjct: 727 LIRGLELTAFALLFGWVFEGFQYLTVDNGKMMHRMAMAVIAYGCSGFGCFVSQFLSSVFF 786
Query: 1491 AVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVX 1312
A+VSENL++RFRV SFRNLLYQDAS+FDNPAHAPGKLITRLA+DAPN K VVD+RMLQV
Sbjct: 787 AIVSENLALRFRVMSFRNLLYQDASFFDNPAHAPGKLITRLATDAPNCKTVVDSRMLQVL 846
Query: 1311 XXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQNDDAGRIAI 1132
IYCW LA M GLAYKISL+N++QIQ+D+AGRIAI
Sbjct: 847 YALSAIIANIAIAFIYCWYLAILGTALIILLAVTMCGLAYKISLLNMKQIQDDEAGRIAI 906
Query: 1131 EIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYA 952
EIIENVKTIQLLTRC+ FF+ YQ SSK QKRSELKKG+IEA+NY++TQSFMY+MMCF +A
Sbjct: 907 EIIENVKTIQLLTRCDHFFERYQKSSKSQKRSELKKGLIEAVNYTITQSFMYYMMCFCFA 966
Query: 951 VGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRT 772
+GIR+IYQG+KSS D F+G IAM+L A+ VMNSAQYFPEFVKAKTA+G+LFNIIYRKPRT
Sbjct: 967 LGIRLIYQGNKSSQDVFQGNIAMLLTAMGVMNSAQYFPEFVKAKTASGLLFNIIYRKPRT 1026
Query: 771 GDLMEGDRPEIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNI 592
GDLMEG PE+RGNILFE+VKFSYPQRP QPIMKGLQWTALRGQTVALVGPSGSGKST I
Sbjct: 1027 GDLMEGTCPEVRGNILFEDVKFSYPQRPHQPIMKGLQWTALRGQTVALVGPSGSGKSTCI 1086
Query: 591 GMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGLKDVPL 412
GMLERFYDVTGG LRIDGQDIR LSLFHLRTQMALVGQEPRLFAGTI+EN+CLGL++V +
Sbjct: 1087 GMLERFYDVTGGVLRIDGQDIRGLSLFHLRTQMALVGQEPRLFAGTIKENICLGLENVSM 1146
Query: 411 EKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEA 232
EKIN ALELANANRFL+NLPAGI+TDVGEKG +LSGGQKQRIAIARALVRDPKILLLDEA
Sbjct: 1147 EKINHALELANANRFLSNLPAGIETDVGEKGSKLSGGQKQRIAIARALVRDPKILLLDEA 1206
Query: 231 TSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMH 52
TSALDSESE+AVQEALDRAREGRTCITIAHRLSSIQNSD+IVYI+ G+VQEAGNH QLM
Sbjct: 1207 TSALDSESEKAVQEALDRAREGRTCITIAHRLSSIQNSDVIVYIENGRVQEAGNHKQLMA 1266
Query: 51 QKGRYYKLIKKQDLAV 4
+KG+YY+LI+KQDL +
Sbjct: 1267 KKGKYYELIQKQDLGI 1282
>gi|39587990|emb|CAE57221.1| Hypothetical protein CBG00083
[Caenorhabditis briggsae]
Length = 1301
Score = 1773 bits (4592), Expect = 0.0
Identities = 891/1298 (68%), Positives = 1051/1298 (80%), Gaps = 8/1298 (0%)
Frame = -1
Query: 3873 DPKIASDLPANYVDDDDDAPKMYTPSLLEKILNYALCRGDIANQQLEAQPVSIPGLFRYG 3694
+PK + ++Y DDDDD Y PS+ EK +N+ LCR D+++Q LE +PVS+ LFR+
Sbjct: 5 EPKSSISKTSSY-DDDDDEKVEYFPSVFEKAVNFLLCRCDLSSQVLEFKPVSLLQLFRFA 63
Query: 3693 KKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKANENVYIFLGI 3514
FDY+LL IG + +IISGVSQP+LA++SGR+TN LLV P SK+F+NKA ENVYIFLG+
Sbjct: 64 TPFDYILLIIGVVTSIISGVSQPVLAIISGRLTNVLLVVDPLSKEFKNKAMENVYIFLGL 123
Query: 3513 GIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFDKNHSGTITTKLNDSMER 3334
GIF+SI +F QYMCFQ C+R+M QMR+R++ S+LRQNAGWFDKN SGTITT+LND+MER
Sbjct: 124 GIFVSINDFCQYMCFQRVCSRMMTQMRNRYISSILRQNAGWFDKNLSGTITTRLNDNMER 183
Query: 3333 IREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTI 3154
I++G+GDKLGVL+RG +M++ +++++ +YEWRLA MM+G+ P ICM+LL+R + +T
Sbjct: 184 IQDGVGDKLGVLIRGISMVLTSVIISLVYEWRLALMMVGLIPVSTICMTLLSRFLEKSTG 243
Query: 3153 KELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXX 2974
+EL VG AG+IAEESLMGVRT+QAFNGQEEMV +YE L G++ A+
Sbjct: 244 EELEKVGIAGAIAEESLMGVRTIQAFNGQEEMVAKYEKHLNSGKRHAIIGGFWSGFFGGM 303
Query: 2973 XXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARV 2794
GCG+LYG YLLKVGII +PGDVFI++M+MLLGAYFLGLISPH+MVLLNARV
Sbjct: 304 FFFWLLAFMGCGILYGGYLLKVGIIKSPGDVFIIIMAMLLGAYFLGLISPHLMVLLNARV 363
Query: 2793 SAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPG 2614
+AASIY+TIDRVPKIDPYSKAGK+L VVG+V F NVHFRYP+RK+AK+LNGL+L VEPG
Sbjct: 364 AAASIYKTIDRVPKIDPYSKAGKKLDRVVGKVTFRNVHFRYPTRKEAKVLNGLDLTVEPG 423
Query: 2613 TSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILF 2434
TSVALVGHSGCGKSTSVGLLTRLYEPE G+V IDG DVR+LN++WLRN VGIVQQEPILF
Sbjct: 424 TSVALVGHSGCGKSTSVGLLTRLYEPEDGSVQIDGVDVRDLNMDWLRNIVGIVQQEPILF 483
Query: 2433 NDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVA 2254
NDTIHNNLLIGNP +TRE MIEVCKMANAHDFI+KMPKGYDTLIGDGGVQLSGGQKQRVA
Sbjct: 484 NDTIHNNLLIGNPDATREKMIEVCKMANAHDFIKKMPKGYDTLIGDGGVQLSGGQKQRVA 543
Query: 2253 IARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVF 2074
IARTLIRDPK+LLLDEATSALDAQSES+VQSALNNA++GRTTIMIAHRLSTIREADKIVF
Sbjct: 544 IARTLIRDPKILLLDEATSALDAQSESVVQSALNNAARGRTTIMIAHRLSTIREADKIVF 603
Query: 2073 FEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKADPXXXXXXXXXEIDLDD-------TXX 1915
FEKGVIVEAGNH ELV LGGRY++LVKAQQFK DP E D+ T
Sbjct: 604 FEKGVIVEAGNHGELVALGGRYYNLVKAQQFKQDPEDIELEAEQEDQFDEFEKPTMFTRQ 663
Query: 1914 XXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKR-SXXXXXXXXXXXXXXXXXXXEDGQITA 1738
S+ FRRG N SF ++ S +D ++TA
Sbjct: 664 VSTRSSRSSGRSGSDEFRRGTLANHSFDRFRKPSHVPTAEDEAFALKVKETMEKDEEVTA 723
Query: 1737 GYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMA 1558
GYLDIFKNA GNY YMF+G V ALIRGL+LPA AL+ WVFEGF FVPYGG+MMHR M+
Sbjct: 724 GYLDIFKNAHGNYGYMFIGLVAALIRGLDLPAFALLLSWVFEGFEFVPYGGKMMHRFVMS 783
Query: 1557 VIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLI 1378
VIA VG+G+WF Q S+V+FA+VSENL +RFRV +FRNLLYQD++YFDNPAHAPG LI
Sbjct: 784 VIAHCGVGLGIWFFQTLSTVMFAIVSENLGVRFRVDAFRNLLYQDSAYFDNPAHAPGSLI 843
Query: 1377 TRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGL 1198
TRLA+D P++KAVVD RM+QV IYCWQ L FVM GL
Sbjct: 844 TRLAADPPSVKAVVDGRMMQVIYAFSAVVACVTIGFIYCWQVAILGTSLIFFLGFVMCGL 903
Query: 1197 AYKISLMNVEQIQNDDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGM 1018
A+KI+++ VE +QNDDAG++AIEIIENVKTIQLLTR + F + Y+ SK++K +EL+K +
Sbjct: 904 AFKITILAVEHMQNDDAGKVAIEIIENVKTIQLLTRTKRFLNSYENESKKRKTTELRKSV 963
Query: 1017 IEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFP 838
EAINYS+TQ+FMY+M CF +A+ IR+I +GD+ D TF+ ++AMML ++ SAQ+FP
Sbjct: 964 FEAINYSITQNFMYYMSCFCFALAIRVINEGDQPVDKTFRSLMAMMLCCEGIILSAQFFP 1023
Query: 837 EFVKAKTAAGMLFNIIYRKPRTGDLMEGDRPEIRGNILFENVKFSYPQRPLQPIMKGLQW 658
+FV AK+AAG +FN+IYRKP+TGD+ G +PEIRGNILFENVKFSYPQRP QP+MK LQW
Sbjct: 1024 QFVGAKSAAGQMFNLIYRKPQTGDVKTGSQPEIRGNILFENVKFSYPQRPHQPVMKTLQW 1083
Query: 657 TALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQ 478
TALRGQTVA+VGPSGSGKST I MLERFYDVTGGALRIDGQDIR +SL+HLRTQMALVGQ
Sbjct: 1084 TALRGQTVAIVGPSGSGKSTCISMLERFYDVTGGALRIDGQDIRTMSLYHLRTQMALVGQ 1143
Query: 477 EPRLFAGTIRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQ 298
EPRLF GTIREN+CLGLKDVPLEKINQALELANANRFL NLPAGIDT+VGE+GGQLSGGQ
Sbjct: 1144 EPRLFVGTIRENICLGLKDVPLEKINQALELANANRFLGNLPAGIDTEVGERGGQLSGGQ 1203
Query: 297 KQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNS 118
KQRIAIARALVRDPKILLLDEATSALDSESE+AVQEALDRAREGRTCITIAHRLSSIQNS
Sbjct: 1204 KQRIAIARALVRDPKILLLDEATSALDSESEKAVQEALDRAREGRTCITIAHRLSSIQNS 1263
Query: 117 DLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQDLAV 4
DLIVYID G+VQEAG H +LMH KG+Y++LIKKQDLA+
Sbjct: 1264 DLIVYIDDGRVQEAGTHNELMHMKGKYFELIKKQDLAI 1301
>gi|17567267|ref|NP_510127.1| P-GlycoProtein related (pgp-13)
[Caenorhabditis elegans]
gi|7499664|pir||T21267 hypothetical protein F22E10.2 - Caenorhabditis
elegans
gi|3876292|emb|CAA91800.1| Hypothetical protein F22E10.2
[Caenorhabditis elegans]
Length = 1291
Score = 1689 bits (4374), Expect = 0.0
Identities = 864/1290 (66%), Positives = 1008/1290 (77%), Gaps = 9/1290 (0%)
Frame = -1
Query: 3846 ANYVDDDDDAPKMYTPSLLEKILNYALCRGDIANQQLEAQPVSIPGLFRYGKKFDYLLLF 3667
++Y DDD+D Y PS+ EK +N+ LCR D++ Q LE QPVS+ LFR+ FDY+LL
Sbjct: 35 SSYNDDDNDKKVEYYPSVFEKFVNFLLCRCDLSEQVLEFQPVSLLQLFRFATTFDYILLL 94
Query: 3666 IGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKANENVYIFLGIGIFISITNF 3487
IG I ++ISGVSQP+LA++SGR+TN LLV P SK+F+ K ENVYIFLG+GIF+SI +F
Sbjct: 95 IGLITSVISGVSQPVLAIISGRMTNVLLVIDPLSKEFKTKTMENVYIFLGLGIFVSINDF 154
Query: 3486 IQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKL 3307
QYMCFQ C+R+M MR+R++ S+LRQNAGWFDKN SGTITT+LND+MERI++G+GDKL
Sbjct: 155 CQYMCFQRVCSRMMTVMRNRYISSILRQNAGWFDKNLSGTITTRLNDNMERIQDGVGDKL 214
Query: 3306 GVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKA 3127
GVL+RG +M+IA++V++ IYEWRLA MMLG+ P ICM+LL+R + +T +EL VG+A
Sbjct: 215 GVLIRGISMVIASVVISLIYEWRLALMMLGLIPVSTICMTLLSRFLEKSTGEELEKVGEA 274
Query: 3126 GSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXX 2947
G+IAEE LMGVRT+QAFNGQEEMV +YE +L G+K A+W
Sbjct: 275 GAIAEECLMGVRTIQAFNGQEEMVAKYEKQLNSGKKHAIWGGFWSGFFGGIFFFWLMAFM 334
Query: 2946 GCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTI 2767
GCG+LYG YLLKVGII +P AASIY+TI
Sbjct: 335 GCGILYGGYLLKVGIIKSP---------------------------------AASIYKTI 361
Query: 2766 DRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHS 2587
DRVPKIDPYS+ GK+++ VVG+V FENVHFRYP+RK+AK+LNGLNL VEPGTSVALVGHS
Sbjct: 362 DRVPKIDPYSRHGKKIEKVVGKVTFENVHFRYPTRKEAKVLNGLNLTVEPGTSVALVGHS 421
Query: 2586 GCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLL 2407
GCGKSTSVGLLTRLYEPE G+V IDG DVR+LN+EWLRN VGIVQQEPILFNDTIHNNLL
Sbjct: 422 GCGKSTSVGLLTRLYEPEQGSVQIDGVDVRDLNLEWLRNVVGIVQQEPILFNDTIHNNLL 481
Query: 2406 IGNPGSTRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDP 2227
GNP +TRETMI VCKMANAHDFI+KMPKGYDT IGDGGVQLSGGQKQRVAIARTLIRDP
Sbjct: 482 FGNPDATRETMIRVCKMANAHDFIKKMPKGYDTQIGDGGVQLSGGQKQRVAIARTLIRDP 541
Query: 2226 KVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEA 2047
KVLLLDEATSALDAQSES+VQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEA
Sbjct: 542 KVLLLDEATSALDAQSESVVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEA 601
Query: 2046 GNHEELVRLGGRYFDLVKAQQFKADPXXXXXXXXXEIDLDD-------TXXXXXXXXXXX 1888
GNHEELV LGGRYFDLVKAQ FK DP E D+
Sbjct: 602 GNHEELVNLGGRYFDLVKAQAFKQDPDEIALEKEEEDQFDEFDKPTVFNRKVSVRNSRSS 661
Query: 1887 XXXXSEAFRRGNSLNDSFSG-SKRSXXXXXXXXXXXXXXXXXXXEDGQITAGYLDIFKNA 1711
SE FRRG+ N SF K S +DG+ITAG+LDIFKNA
Sbjct: 662 GRSGSEEFRRGSLANHSFDRFRKASHIPSAEDEAFALRVKETMEKDGEITAGFLDIFKNA 721
Query: 1710 KG-NYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVG 1534
+G NY YM +G ALIRGL+LP AL+F WVFEGF FVPYGG+MMHR+AM+VIA + G
Sbjct: 722 QGRNYTYMLIGLSAALIRGLDLPTFALLFAWVFEGFEFVPYGGKMMHRLAMSVIAHCAAG 781
Query: 1533 VGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAP 1354
+G+WF Q S+V+FA+VSENL +RFRV +FRNLLYQDA+YFDNPAHAPG LITRLA+D P
Sbjct: 782 LGIWFFQTLSTVMFAIVSENLGVRFRVAAFRNLLYQDAAYFDNPAHAPGSLITRLAADPP 841
Query: 1353 NIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMN 1174
+KAVVD RM+QV I CWQ L F+M GLA+KIS++
Sbjct: 842 CVKAVVDGRMMQVVYATAAVIACVTIGFINCWQVAILGTALIFLLGFIMAGLAFKISIVA 901
Query: 1173 VEQIQNDDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSL 994
E ++NDDAG+IAIEIIENVKTIQLLTR F + Y+ SK++KR+EL+K + EA+NY +
Sbjct: 902 AEHMENDDAGKIAIEIIENVKTIQLLTRTRRFLNSYENESKKRKRTELRKSVYEAVNYCI 961
Query: 993 TQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTA 814
+Q+FMY+M CF +A+ IRII QGD++ D TF+ ++AMML ++ SAQ+FP+FV AK+A
Sbjct: 962 SQNFMYYMSCFCFALAIRIINQGDQTVDKTFRCLMAMMLCCEGIIMSAQFFPQFVGAKSA 1021
Query: 813 AGMLFNIIYRKPRTGDLMEGDRPEIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTV 634
AG +FN+I R+P+TGDL G +PEIRGNILFENVKFSYPQRP QP+MK LQWTALRGQTV
Sbjct: 1022 AGQMFNLINRQPQTGDLKSGTKPEIRGNILFENVKFSYPQRPHQPVMKQLQWTALRGQTV 1081
Query: 633 ALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGT 454
ALVGPSGSGKST IGMLERFYDVTGGALR+DGQDI+ +SL+HLRTQMALVGQEPRLF GT
Sbjct: 1082 ALVGPSGSGKSTCIGMLERFYDVTGGALRMDGQDIKNISLYHLRTQMALVGQEPRLFVGT 1141
Query: 453 IRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIAR 274
IRENVCLGLKDVPLEKINQALELANANRFL NLP GIDT+VGE+GGQLSGGQKQRIAIAR
Sbjct: 1142 IRENVCLGLKDVPLEKINQALELANANRFLGNLPDGIDTEVGERGGQLSGGQKQRIAIAR 1201
Query: 273 ALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDK 94
ALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYID
Sbjct: 1202 ALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDD 1261
Query: 93 GKVQEAGNHTQLMHQKGRYYKLIKKQDLAV 4
G+VQE+G H +LM KG+Y++LIKKQDLA+
Sbjct: 1262 GRVQESGTHKELMQLKGKYFELIKKQDLAI 1291
>gi|17567265|ref|NP_510126.1| P-GlycoProtein related (pgp-12)
[Caenorhabditis elegans]
gi|7499663|pir||T21266 hypothetical protein F22E10.1 - Caenorhabditis
elegans
gi|3876291|emb|CAA91799.1| Hypothetical protein F22E10.1
[Caenorhabditis elegans]
Length = 1318
Score = 1605 bits (4156), Expect = 0.0
Identities = 821/1299 (63%), Positives = 990/1299 (76%), Gaps = 6/1299 (0%)
Frame = -1
Query: 3888 NDPKSDPKI-ASDLPANYVDDDDDAPKMYTPSLLEKILNYALCRGDIANQQLEAQPVSIP 3712
N K D + S +D D++ +Y PS +EK++NY LCRGD+A+++L +PV++
Sbjct: 20 NGKKKDTTVNVSTEDVGSIDSDEEPKIVYEPSKMEKLINYMLCRGDLASRELSVKPVTLL 79
Query: 3711 GLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKANENV 3532
GLFRY ++ DY LL G + ISG++QP L +++G +TN+LL++ TS F + A NV
Sbjct: 80 GLFRYAERTDYALLCFGIFLSFISGIAQPGLGIIAGNITNSLLIHNATSDDFYDSAMTNV 139
Query: 3531 YIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFDKNHSGTITTKL 3352
++F GIGI + I NF+QYMCFQ+CC R+ ++M+ ++ S+LRQNAGWFDKNHSGT+TTKL
Sbjct: 140 WLFGGIGIIVLIVNFVQYMCFQYCCIRITSKMKQHYIQSILRQNAGWFDKNHSGTLTTKL 199
Query: 3351 NDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQ 3172
+D+MERI EGIGDKLGVL+RG M +A IV+++ YEWRLA MM+G+ P CC+CMSL++R
Sbjct: 200 HDNMERINEGIGDKLGVLIRGMVMFVAGIVISFFYEWRLALMMMGIGPLCCVCMSLMSRS 259
Query: 3171 MTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXX 2992
M+S T KEL GVGKAGSIAEESLMGVRTVQAFNGQEEMV +Y EL KG+ FA+ K
Sbjct: 260 MSSFTSKELAGVGKAGSIAEESLMGVRTVQAFNGQEEMVEKYTVELGKGKSFAIQKGLWG 319
Query: 2991 XXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMV 2812
G G+ YG LL+ II TPGDVFIVV+SML+GAYFLGLISPH+MV
Sbjct: 320 GVFGGIFLLFLFSYFGGGIYYGGQLLRWKIIETPGDVFIVVISMLIGAYFLGLISPHLMV 379
Query: 2811 LLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLN 2632
LLNARV+AA+IY+ IDR P ID YS G+++ NVVG+V FE VHFRYP+RK K+LNGLN
Sbjct: 380 LLNARVAAATIYEIIDRTPDIDVYSTEGQKMTNVVGKVVFEEVHFRYPTRKKVKVLNGLN 439
Query: 2631 LVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQ 2452
L V+PGTSVALVGHSGCGKSTSVGLLTRLYEPE G V IDG DVR LNI+WLR TVGIVQ
Sbjct: 440 LTVKPGTSVALVGHSGCGKSTSVGLLTRLYEPEGGKVMIDGQDVRSLNIDWLRKTVGIVQ 499
Query: 2451 QEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGG 2272
QEPILFNDTIHNNLLIGNP +TRE MI VCKMANAHDFI+KMP GY+T+IGDG VQLSGG
Sbjct: 500 QEPILFNDTIHNNLLIGNPSATREDMIRVCKMANAHDFIQKMPNGYETMIGDGSVQLSGG 559
Query: 2271 QKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIRE 2092
QKQRVAIARTLIRDPKVLLLDEATSALDAQSES+VQSALNNA+KGRTTIMIAHRLSTIRE
Sbjct: 560 QKQRVAIARTLIRDPKVLLLDEATSALDAQSESVVQSALNNAAKGRTTIMIAHRLSTIRE 619
Query: 2091 ADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFK-----ADPXXXXXXXXXEIDLD 1927
ADKIVFFE GVIVE+GNHEELV LGGRY LV+AQ+FK D +
Sbjct: 620 ADKIVFFENGVIVESGNHEELVALGGRYAKLVEAQKFKESDDIEDNGDEHEEETSTVGRH 679
Query: 1926 DTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXXXXXXXXXXXXXXXEDGQ 1747
D + A + + + ++ EDG
Sbjct: 680 DRLSSRQVSFHKSCESLASADLEIGYASTFNTFTLKTAQEEIENEDFAEEVQRVMEEDGV 739
Query: 1746 ITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGRMMHRM 1567
I +GYLDIFKNA+GNYLY+ +GT FA++RG EL LA +FG+VF F M+ +
Sbjct: 740 INSGYLDIFKNAQGNYLYLSVGTFFAILRGSELALLANMFGFVFAAFK--EPEDEMVKAL 797
Query: 1566 AMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPG 1387
+ I + ++G+ V+ +Q+ S LF +V+ENL ++FRVQSF+NLLYQDAS+FDNPAHAPG
Sbjct: 798 GLIFILYVALGLFVFITQVISGTLFTIVAENLGLKFRVQSFKNLLYQDASFFDNPAHAPG 857
Query: 1386 KLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVM 1207
KLITRLASDAPN+KAVVD RMLQV I+CW+ A +M
Sbjct: 858 KLITRLASDAPNVKAVVDTRMLQVIYSITSITINLITGYIFCWRIAIAGTIMIVLFATMM 917
Query: 1206 IGLAYKISLMNVEQIQNDDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELK 1027
I +AYKI+ N++QI+ D+AG+IAIEIIE+VKTIQLLT + F HY+ + Q +SE++
Sbjct: 918 ISMAYKIARENLKQIRKDEAGKIAIEIIESVKTIQLLTSTQRFLTHYKDAQLVQHKSEMR 977
Query: 1026 KGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQ 847
K I+++N +++Q+FMYF M Y VG ++Y G ++ TF+ I MM+G+VAVM+S+
Sbjct: 978 KSYIQSVNNAISQTFMYFAMFVCYGVGTPLMYHGIVEAEPTFRAINCMMMGSVAVMHSSH 1037
Query: 846 YFPEFVKAKTAAGMLFNIIYRKPRTGDLMEGDRPEIRGNILFENVKFSYPQRPLQPIMKG 667
FPEFVKAKTAAGMLF +IYRK +TGD+MEG+ EIRGN+LFE+VKFSYPQRP+QP+M
Sbjct: 1038 NFPEFVKAKTAAGMLFKLIYRKSKTGDVMEGNNTEIRGNVLFESVKFSYPQRPMQPVMTD 1097
Query: 666 LQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMAL 487
L ++A GQTVALVGPSG+GKST I MLERFYDV+GGALRIDGQ+I+ LSL HLRTQMAL
Sbjct: 1098 LHFSAHSGQTVALVGPSGTGKSTCIAMLERFYDVSGGALRIDGQNIKSLSLHHLRTQMAL 1157
Query: 486 VGQEPRLFAGTIRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLS 307
VGQEPRLFAGTI+ENVC GLKDV +EK++QALELANA+RFLANLPAGIDT+VGEKGGQLS
Sbjct: 1158 VGQEPRLFAGTIKENVCFGLKDVSVEKVHQALELANASRFLANLPAGIDTEVGEKGGQLS 1217
Query: 306 GGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSI 127
GGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSI
Sbjct: 1218 GGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSI 1277
Query: 126 QNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQDL 10
QNSDLIVYID G VQEAGNH LM +G+YY LIKKQDL
Sbjct: 1278 QNSDLIVYIDHGMVQEAGNHAHLMSLRGKYYNLIKKQDL 1316
>gi|39587992|emb|CAE57223.1| Hypothetical protein CBG00086
[Caenorhabditis briggsae]
Length = 1316
Score = 1602 bits (4148), Expect = 0.0
Identities = 826/1288 (64%), Positives = 985/1288 (76%), Gaps = 12/1288 (0%)
Frame = -1
Query: 3837 VDDDDDAPKMYTPSLLEKILNYALCRGDIANQQLEAQPVSIPGLFRYGKKFDYLLLFIGT 3658
+D D++ +Y PS LEK +NY LCRGD+A ++L +PV++ GLFR+ ++ D+++L IG
Sbjct: 38 IDSDEEPKFVYEPSHLEKFINYMLCRGDLAKRELSVKPVTLLGLFRFAERRDHIILLIGI 97
Query: 3657 ICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKANENVYIFLGIGIFISITNFIQY 3478
+ + +SGV+QP L +++G +TN L+VY TS QF + A NVY+F GIG+ + I NFIQY
Sbjct: 98 LLSFLSGVAQPGLGVIAGGMTNTLIVYNVTSPQFLDSALMNVYLFGGIGVVVLIINFIQY 157
Query: 3477 MCFQHCCTRVMAQMRHRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVL 3298
MCFQ+ C R++ ++R ++ S+LRQNAGWFDKNHSGT+TTKL+D+MERI EGIGDKLGVL
Sbjct: 158 MCFQNVCIRIVTKLREEYIKSILRQNAGWFDKNHSGTLTTKLHDNMERIHEGIGDKLGVL 217
Query: 3297 LRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSI 3118
+RG M IV++ YEWRLA MM+G+ P CCICMSL++R M+S T KEL VGKAGSI
Sbjct: 218 IRGIVMFGTGIVISLFYEWRLALMMMGIGPLCCICMSLMSRSMSSYTSKELADVGKAGSI 277
Query: 3117 AEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCG 2938
AEESLMGVRTVQAFNGQEEMVGRY AEL KG+ +AV K G G
Sbjct: 278 AEESLMGVRTVQAFNGQEEMVGRYTAELGKGKSYAVKKGLWGGFFGGIFLLILFTYFGGG 337
Query: 2937 MLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRV 2758
+ YG LL+ II PGDVFIVV SML+GAYFLGLISPH+MVLLNARV+AA+IY+ IDRV
Sbjct: 338 IFYGGQLLRWKIIENPGDVFIVVFSMLIGAYFLGLISPHLMVLLNARVAAATIYEVIDRV 397
Query: 2757 PKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCG 2578
P+ID YS G+++ +VGRV FENVHFRYP+RK AK+LNGLNL +EPGTSVALVGHSGCG
Sbjct: 398 PEIDAYSNEGQKIDKIVGRVVFENVHFRYPTRKKAKVLNGLNLTIEPGTSVALVGHSGCG 457
Query: 2577 KSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGN 2398
KSTSVGLLTRLYE E G V IDG +VR LNI+WLR VGIVQQEPILF+ TIHNNLLIGN
Sbjct: 458 KSTSVGLLTRLYEQEDGKVMIDGHEVRNLNIDWLRKVVGIVQQEPILFSGTIHNNLLIGN 517
Query: 2397 PGSTRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVL 2218
P +TR+ MI VCKMANAH+FI KMPKGYDT+IGDGGVQLSGGQKQRVAIARTLIRDPKVL
Sbjct: 518 PNATRDDMIRVCKMANAHEFILKMPKGYDTVIGDGGVQLSGGQKQRVAIARTLIRDPKVL 577
Query: 2217 LLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNH 2038
LLDEATSALDAQSES+VQSALNNASKGRTTIMIAHRLSTIREADKIVFFE GVIVE+G H
Sbjct: 578 LLDEATSALDAQSESVVQSALNNASKGRTTIMIAHRLSTIREADKIVFFESGVIVESGTH 637
Query: 2037 EELVRLGGRYFDLVKAQQFKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRR 1858
+ELV LGGRY LVKAQQFK E+D D +
Sbjct: 638 DELVALGGRYAALVKAQQFK---------EADEVDDDVEEDITARIFSEKQMPSRQVSYH 688
Query: 1857 GNSLNDSFSGSKRSXXXXXXXXXXXXXXXXXXXED------------GQITAGYLDIFKN 1714
G+ ++ + + + ED G IT+GY DIFKN
Sbjct: 689 GSCVSLASADLEIGYASAFNSFNLKQAQDDIENEDFAEEVQRVMEEDGVITSGYYDIFKN 748
Query: 1713 AKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVG 1534
AKGNY Y+ +GTVFA++RG EL LA++FG+VFE F M + + I + +G
Sbjct: 749 AKGNYWYLSMGTVFAIMRGSELALLAIMFGYVFEAFE--KPDAEMARELVIIFILYGCLG 806
Query: 1533 VGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAP 1354
+ V+ +Q+ SS LF +V+ENL ++FRVQSF+NLLYQDAS+FDNPAHAPGKLITRLA+DAP
Sbjct: 807 LYVFITQVLSSTLFTIVAENLGLKFRVQSFKNLLYQDASFFDNPAHAPGKLITRLATDAP 866
Query: 1353 NIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMN 1174
N+KAVVD RMLQV CWQ A +MI +AYKI+ +N
Sbjct: 867 NVKAVVDTRMLQVIYSMTSITINLVTGYACCWQIAVVGTVMIALFALLMISMAYKIARVN 926
Query: 1173 VEQIQNDDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSL 994
++QI+ D+AG+IAIEI+ENVKTIQLLT E F Y T+ + Q +SE+KK I+A+N ++
Sbjct: 927 LKQIKRDEAGKIAIEIVENVKTIQLLTSTEHFLTEYTTALELQHKSEMKKAYIQALNNAI 986
Query: 993 TQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTA 814
+Q+FMYF M YAVG ++Y G + F+ I +MM+G+VAVM+S+ FPEFVKAKTA
Sbjct: 987 SQTFMYFAMFVCYAVGTPLMYNGIVDPNGAFRAINSMMMGSVAVMHSSHNFPEFVKAKTA 1046
Query: 813 AGMLFNIIYRKPRTGDLMEGDRPEIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTV 634
AGMLF +IYRKP+TGD+M+G++ +IRGNILFE+VKFSYPQRPL P+M L +TA GQTV
Sbjct: 1047 AGMLFKLIYRKPKTGDVMKGNQLDIRGNILFESVKFSYPQRPLHPVMTDLHFTARNGQTV 1106
Query: 633 ALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGT 454
ALVGPSG+GKST I MLERFYDV+GGALRIDGQDI+ LSL HLRTQMALVGQEPRLFAGT
Sbjct: 1107 ALVGPSGTGKSTCIAMLERFYDVSGGALRIDGQDIKTLSLHHLRTQMALVGQEPRLFAGT 1166
Query: 453 IRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIAR 274
IRENVC GLKDVP+EK+NQALELANA+RFLANLP+GIDT+VGEKG QLSGGQKQRIAIAR
Sbjct: 1167 IRENVCFGLKDVPIEKVNQALELANASRFLANLPSGIDTEVGEKGSQLSGGQKQRIAIAR 1226
Query: 273 ALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDK 94
ALVRDPKILLLDEATSALDSESER +QEALDRAREGRTCITIAHRLSSIQNSDLIVYID+
Sbjct: 1227 ALVRDPKILLLDEATSALDSESERVMQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDQ 1286
Query: 93 GKVQEAGNHTQLMHQKGRYYKLIKKQDL 10
GKVQEAGNH LM +G+YY LIKKQDL
Sbjct: 1287 GKVQEAGNHNHLMSLRGKYYDLIKKQDL 1314
>gi|17567271|ref|NP_510129.1| P-GlycoProtein related (pgp-15)
[Caenorhabditis elegans]
gi|7499666|pir||T21269 hypothetical protein F22E10.4 - Caenorhabditis
elegans
gi|3876294|emb|CAA91802.1| Hypothetical protein F22E10.4
[Caenorhabditis elegans]
Length = 1270
Score = 1266 bits (3277), Expect = 0.0
Identities = 649/915 (70%), Positives = 727/915 (78%), Gaps = 7/915 (0%)
Frame = -1
Query: 3984 MAPKDDPDNRGFDDQRRPSQRSTVLAIPALAVNDPKSDPKIASDLPANYVDDDDDAPKMY 3805
M P DP G +D R S++ST+ +PA V++PK + P +VDDD+ K Y
Sbjct: 1 MFPVADPPRAGPEDIGRNSRQSTIRGVPAFPVSEPKH-----TSAPIEFVDDDE-IKKEY 54
Query: 3804 TPSLLEKILNYALCRGDIANQQLEAQPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQP 3625
PS +K++++ LCRGD+A + E QPVSI GLFRY K FD+ LLFIG ICAIISGVSQP
Sbjct: 55 RPSCFDKLIDFILCRGDVAKRTYETQPVSIFGLFRYAKAFDHFLLFIGVICAIISGVSQP 114
Query: 3624 ILALVSGRVTNALLVYPPTSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVM 3445
+L +++GRVTNA+LVY P +KQFRNKA ENVYIFLGIGIF++ITN+IQYMCFQHCC+R+M
Sbjct: 115 VLTIIAGRVTNAILVYAPQTKQFRNKATENVYIFLGIGIFVTITNYIQYMCFQHCCSRIM 174
Query: 3444 AQMRHRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAI 3265
AQMRHR+VYSVLRQNAGWFDK+HSGTI TKLNDSMERIREGIGDKLGVLLRG AML+A++
Sbjct: 175 AQMRHRYVYSVLRQNAGWFDKHHSGTIATKLNDSMERIREGIGDKLGVLLRGVAMLVASV 234
Query: 3264 VVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTV 3085
VVAYIYEWRLA M+LGVAPTC CMSL+ARQMT+TT+KEL GV KAGSIAEESLMGVRTV
Sbjct: 235 VVAYIYEWRLACMLLGVAPTCIGCMSLMARQMTATTVKELGGVEKAGSIAEESLMGVRTV 294
Query: 3084 QAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVG 2905
QAFNGQEEMV RY EL KGRKFA+WK GCG LYGAYLL VG
Sbjct: 295 QAFNGQEEMVERYRVELNKGRKFAIWKGFWSGLFGGMFFFWLFAFQGCGFLYGAYLLSVG 354
Query: 2904 IITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGK 2725
II +PGDVFI+VM+MLLG+YF GLISPH+MVLLNARV+A SIY+TIDRVPKIDPYSK GK
Sbjct: 355 IIKSPGDVFIIVMAMLLGSYFTGLISPHLMVLLNARVAAGSIYETIDRVPKIDPYSKKGK 414
Query: 2724 RLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRL 2545
L V+GRVKFENVHFRYP+RKDAKILNGLNL +EPGTSVALVGHSGCGKSTSVGLLTRL
Sbjct: 415 FLDKVIGRVKFENVHFRYPTRKDAKILNGLNLTIEPGTSVALVGHSGCGKSTSVGLLTRL 474
Query: 2544 YEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEV 2365
YEPEAGNVTIDGTDVRELNI++LRN +GIVQQEPILFNDTIHNNLL+GNP +TRE MIEV
Sbjct: 475 YEPEAGNVTIDGTDVRELNIDYLRNVIGIVQQEPILFNDTIHNNLLLGNPNATREKMIEV 534
Query: 2364 CKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDA 2185
CKMANAHDFIEKMPKGYDT+IGDGGVQLSGGQKQRVAIARTL+R+PKVLLLDEATSALDA
Sbjct: 535 CKMANAHDFIEKMPKGYDTMIGDGGVQLSGGQKQRVAIARTLVREPKVLLLDEATSALDA 594
Query: 2184 QSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYF 2005
QSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRY+
Sbjct: 595 QSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYY 654
Query: 2004 DLVKAQQFKADPXXXXXXXXXEIDLDDTXX------XXXXXXXXXXXXXSEAFRRGNSLN 1843
DLVKAQ FK D EIDL + +EAFRRG
Sbjct: 655 DLVKAQAFKPDNDGTVDEIEDEIDLGQSASGLHSRQSSFTSSIRSKMSGAEAFRRGTLGA 714
Query: 1842 DSFSGSKRSXXXXXXXXXXXXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALI 1663
DSF+G K + +DGQI+AGY+DIFKNAKGNY MFLG V LI
Sbjct: 715 DSFAGGKSTARADAENAAFAEEVAKVMEQDGQISAGYMDIFKNAKGNYTVMFLGFVTGLI 774
Query: 1662 RGLELPALALIFGWVFEGFTFVPY-GGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAV 1486
RGLEL A AL+ GWVFEGF ++ G+MMHRMAMAVIA+ G G + SQ SS+ FA+
Sbjct: 775 RGLELTAFALLLGWVFEGFQYLNIDNGKMMHRMAMAVIAYGCSGFGCFISQFLSSIFFAI 834
Query: 1485 VSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXX 1306
VSENL++RFRV SFRNLLYQDAS+FDNPAHAPGKLITRLA+DAPN K VVD+RMLQV
Sbjct: 835 VSENLALRFRVMSFRNLLYQDASFFDNPAHAPGKLITRLATDAPNCKTVVDSRMLQVLYA 894
Query: 1305 XXXXXXXXXXXXIYC 1261
IYC
Sbjct: 895 LSAIIANIVISFIYC 909
Score = 601 bits (1549), Expect = e-170
Identities = 301/356 (84%), Positives = 331/356 (92%)
Frame = -1
Query: 1071 HYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGI 892
HY T KRSELKKG+IEAINY++TQSFMY+MMCF +A+GIR+IY G+KS D F+G
Sbjct: 916 HYFTRF-YNKRSELKKGLIEAINYTITQSFMYYMMCFCFALGIRLIYHGNKSPQDVFQGN 974
Query: 891 IAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLMEGDRPEIRGNILFENV 712
IAM+L A+ VMN+AQYFPEFVKAKTAAG+LFNIIYRKPRTGDL+EG RPE+RGNILFENV
Sbjct: 975 IAMLLTAMGVMNAAQYFPEFVKAKTAAGLLFNIIYRKPRTGDLLEGSRPEVRGNILFENV 1034
Query: 711 KFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQD 532
KFSYPQRP QPIMKGLQWTALRGQTVALVGPSGSGKST IGMLERFYDVTGG LRIDGQD
Sbjct: 1035 KFSYPQRPHQPIMKGLQWTALRGQTVALVGPSGSGKSTCIGMLERFYDVTGGTLRIDGQD 1094
Query: 531 IRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGLKDVPLEKINQALELANANRFLANLP 352
IR LSLFHLRTQMALVGQEPRLFAGTI+EN+CLGL++VP+EKIN ALELANANRFLANLP
Sbjct: 1095 IRGLSLFHLRTQMALVGQEPRLFAGTIKENICLGLENVPMEKINHALELANANRFLANLP 1154
Query: 351 AGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAR 172
AGI+TDVGEKG +LSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAR
Sbjct: 1155 AGIETDVGEKGSKLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAR 1214
Query: 171 EGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQDLAV 4
EGRTCITIAHRLSSIQNSD+IVYI+ G+VQEAGNH QLM +KG+YY+LI+KQDL +
Sbjct: 1215 EGRTCITIAHRLSSIQNSDVIVYIENGRVQEAGNHKQLMSKKGKYYELIQKQDLGI 1270
Score = 305 bits (780), Expect = 8e-81
Identities = 194/583 (33%), Positives = 308/583 (52%), Gaps = 13/583 (2%)
Frame = -1
Query: 1725 IFKNAKG-NYLYMFLGTVFALIRGLELPALALIFGWVFEGF-TFVPYGGRMMHRMAMAVI 1552
+F+ AK ++ +F+G + A+I G+ P L +I G V + P + ++ V
Sbjct: 87 LFRYAKAFDHFLLFIGVICAIISGVSQPVLTIIAGRVTNAILVYAPQTKQFRNKATENVY 146
Query: 1551 AFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITR 1372
F +G+ V + + F + + R + ++L Q+A +FD H G + T+
Sbjct: 147 IFLGIGIFVTITNYIQYMCFQHCCSRIMAQMRHRYVYSVLRQNAGWFDK--HHSGTIATK 204
Query: 1371 LASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAY 1192
L I+ + ++ + IY W+ M +A
Sbjct: 205 LNDSMERIREGIGDKLGVLLRGVAMLVASVVVAYIYEWRLACMLLGVAPTCIGCMSLMAR 264
Query: 1191 KISLMNVEQIQN-DDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMI 1015
+++ V+++ + AG IA E + V+T+Q E + Y+ + ++ + KG
Sbjct: 265 QMTATTVKELGGVEKAGSIAEESLMGVRTVQAFNGQEEMVERYRVELNKGRKFAIWKGFW 324
Query: 1014 EAINYSLTQSFMYFMMCF--------TYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVM 859
+ + F +++ F Y + + II KS D F ++AM+LG+
Sbjct: 325 SGLFGGM---FFFWLFAFQGCGFLYGAYLLSVGII----KSPGDVFIIVMAMLLGSYFTG 377
Query: 858 NSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLMEGDR--PEIRGNILFENVKFSYPQRPL 685
+ + + A+ AAG ++ I R P+ + + ++ G + FENV F YP R
Sbjct: 378 LISPHLMVLLNARVAAGSIYETIDRVPKIDPYSKKGKFLDKVIGRVKFENVHFRYPTRKD 437
Query: 684 QPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHL 505
I+ GL T G +VALVG SG GKST++G+L R Y+ G + IDG D+R+L++ +L
Sbjct: 438 AKILNGLNLTIEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIDYL 497
Query: 504 RTQMALVGQEPRLFAGTIRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGE 325
R + +V QEP LF TI N+ LG + EK+ + ++ANA+ F+ +P G DT +G+
Sbjct: 498 RNVIGIVQQEPILFNDTIHNNLLLGNPNATREKMIEVCKMANAHDFIEKMPKGYDTMIGD 557
Query: 324 KGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIA 145
G QLSGGQKQR+AIAR LVR+PK+LLLDEATSALD++SE VQ AL+ A +GRT I IA
Sbjct: 558 GGVQLSGGQKQRVAIARTLVREPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIA 617
Query: 144 HRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQ 16
HRLS+I+ +D IV+ +KG + EAGNH +L+ GRYY L+K Q
Sbjct: 618 HRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYYDLVKAQ 660
Score = 243 bits (619), Expect = 4e-62
Identities = 132/303 (43%), Positives = 190/303 (62%)
Frame = -1
Query: 2895 TPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQ 2716
+P DVF ++MLL A + + + + A+ +A ++ I R P+ + +
Sbjct: 966 SPQDVFQGNIAMLLTAMGVMNAAQYFPEFVKAKTAAGLLFNIIYRKPRTGDLLEGSR--P 1023
Query: 2715 NVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEP 2536
V G + FENV F YP R I+ GL G +VALVG SG GKST +G+L R Y+
Sbjct: 1024 EVRGNILFENVKFSYPQRPHQPIMKGLQWTALRGQTVALVGPSGSGKSTCIGMLERFYDV 1083
Query: 2535 EAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKM 2356
G + IDG D+R L++ LR + +V QEP LF TI N+ +G E + ++
Sbjct: 1084 TGGTLRIDGQDIRGLSLFHLRTQMALVGQEPRLFAGTIKENICLGLENVPMEKINHALEL 1143
Query: 2355 ANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSE 2176
ANA+ F+ +P G +T +G+ G +LSGGQKQR+AIAR L+RDPK+LLLDEATSALD++SE
Sbjct: 1144 ANANRFLANLPAGIETDVGEKGSKLSGGQKQRIAIARALVRDPKILLLDEATSALDSESE 1203
Query: 2175 SIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLV 1996
VQ AL+ A +GRT I IAHRLS+I+ +D IV+ E G + EAGNH++L+ G+Y++L+
Sbjct: 1204 RAVQEALDRAREGRTCITIAHRLSSIQNSDVIVYIENGRVQEAGNHKQLMSKKGKYYELI 1263
Query: 1995 KAQ 1987
+ Q
Sbjct: 1264 QKQ 1266
>gi|5733124|gb|AAD49436.1| P-glycoprotein [Onchocerca volvulus]
Length = 1278
Score = 935 bits (2416), Expect = 0.0
Identities = 522/1276 (40%), Positives = 745/1276 (57%), Gaps = 3/1276 (0%)
Frame = -1
Query: 3825 DDAPKMYTPSLLEKILNYALCRGDIANQQLEAQPVSIPGLFRYGKKFDYLLLFIGTICAI 3646
DD+ + Y S ++K ++ LCRGD A Q+L+A+PVS LFR+ D +L I + AI
Sbjct: 12 DDSSEQYEQSAIDKFISIILCRGDFAKQKLDAKPVSFFQLFRFATTCDRFMLSISALLAI 71
Query: 3645 ISGVSQPILALVSGRVTNALLVYPPTSKQ--FRNKANENVYIFLGIGIFISITNFIQYMC 3472
+G+ QP++ L+ G++TN L+ + F +A VY++ IGI + IT IQY+C
Sbjct: 72 FTGIGQPMICLIGGKLTNVFLLTKTFERNDTFWYQAYIYVYLYASIGITMVITTTIQYIC 131
Query: 3471 FQHCCTRVMAQMRHRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLR 3292
++ + MR ++ S+LRQ A WFD+ +GT+T +LN ++E+I++GIGDK+G++LR
Sbjct: 132 AKNASLNITCTMRQEYMKSLLRQEAAWFDQQKTGTLTAQLNANIEKIKDGIGDKVGMILR 191
Query: 3291 GFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAE 3112
G M + +++ +IY+WRL +M G P +S +ARQM ++ + G+A ++ E
Sbjct: 192 GVTMFLTCVIIGFIYDWRLTLVMFGTGPISAALLSTMARQMEHSSSMQSNTDGRAAAVLE 251
Query: 3111 ESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGML 2932
ES+M V+TV A N QE M+ RY A L+ RKFA+ G
Sbjct: 252 ESIMNVKTVAACNAQETMIKRYAATLKACRKFALHAYAFAGFFDGLFFLVLYVFFAAGFY 311
Query: 2931 YGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPK 2752
YGAYL ++ II PG +F V ++ G+Y LG++SPH+M +LNARV+AA IY+ I+R P
Sbjct: 312 YGAYLYQIRIIMNPGYIFAVANLIMFGSYNLGVLSPHLMAVLNARVAAAVIYKIINRKPS 371
Query: 2751 IDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKS 2572
D S G ++ V G ++F+NV F YP K+ +LNGL+ +PG +VALVGHSGCGKS
Sbjct: 372 FDSSSTDGMKVNEVKGEIEFQNVKFSYPKSKEHLVLNGLSWTAKPGDTVALVGHSGCGKS 431
Query: 2571 TSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPG 2392
TS GLLTRLY +G + IDG ++ ++NI LRN VG+VQQEP+LF+ TI N+ +G
Sbjct: 432 TSTGLLTRLYNCNSGAILIDGINICDINIHTLRNIVGVVQQEPLLFSGTIKENIRLGKLD 491
Query: 2391 STRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLL 2212
T + +I+ CK+ANAHDFI K+ +GYDT+IG GG+QLSGGQKQR+AIART++R+P++LLL
Sbjct: 492 LTDQEIIDACKIANAHDFINKLSEGYDTMIGAGGIQLSGGQKQRIAIARTIVRNPRILLL 551
Query: 2211 DEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEE 2032
DEATSALDA+SE IVQ+AL A GRTTI+IAHRLST+R++++I+ +KG + E G H+E
Sbjct: 552 DEATSALDAESEVIVQNALKKAFVGRTTIIIAHRLSTLRDSNQIIVLDKGQVAEIGTHKE 611
Query: 2031 LV-RLGGRYFDLVKAQQFKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRG 1855
L G Y LVK+QQF+A +F RG
Sbjct: 612 LCNNKDGIYASLVKSQQFEAQQKPTSPPVEELPLETFHRSNTRDSRNSSGYGIMSSFTRG 671
Query: 1854 NSLNDSFSGSKRSXXXXXXXXXXXXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTV 1675
+ + SG+ + G ++ N GNY M + +
Sbjct: 672 SIM----SGNVTCVSIPEKSTEITVELNGKKKSKPK---GLWQLYTNCHGNYGKMIIALL 724
Query: 1674 FALIRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVL 1495
+ +RGLELP LIF F F ++ R+ I + ++G+ +++
Sbjct: 725 VSFLRGLELPLFVLIFDLTFVVFAQAKLES-VLERILPIAIIYIALGIACLIVIFSATFT 783
Query: 1494 FAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQV 1315
F +E + R+++ RN+LYQ+A YFD P+ + +TR++ DA +K A
Sbjct: 784 FGWTAECVVDSLRLRAMRNMLYQNAEYFDTPSTSTAVTVTRISVDAQTLKRSRSANDAN- 842
Query: 1314 XXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQNDDAGRIA 1135
I+ W I Y +N ++ G++A
Sbjct: 843 FDNIVAILVLVTIAVIFNWPVGLLAVKSPVTHFDADIDRKYNAE-VNKCALKQIVTGQLA 901
Query: 1134 IEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTY 955
+EI+E ++TIQL+T E F Y + + + K EAI +++T SFM+F +Y
Sbjct: 902 LEIVEQIRTIQLITGEEHFHRLYVQTIEDLLYLQKKSSPYEAILFAVTSSFMFFSDMISY 961
Query: 954 AVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPR 775
A GI +IY G + F ++ A++ + FV A A+ LF II
Sbjct: 962 AAGIALIYYGYSLPQEIFTASWSIATSGWALIMVSGCLNTFVMASPASNSLFRIINTGSD 1021
Query: 774 TGDLMEGDRPEIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTN 595
+ +G RP I G++ F +KFSYP RP + ++ GL A GQTVA+ GPSGSGKST
Sbjct: 1022 MNSVDDGLRPAITGDVQFNKIKFSYPTRPQRNVLNGLNLAAYAGQTVAVTGPSGSGKSTV 1081
Query: 594 IGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGLKDVP 415
I +LERFY G L +D I K+SL +LR Q+ALVGQEP LF+GTI EN+ LG
Sbjct: 1082 IALLERFYRFNSGQLTLDDNSITKISLRYLREQIALVGQEPILFSGTILENILLGTTGKT 1141
Query: 414 LEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDE 235
L + +A ++AN F+ P G DT+VGE G QLSGGQKQRIAIARALVR+PKILLLDE
Sbjct: 1142 LSDVREACKIANIIDFIETSPKGYDTEVGEHGVQLSGGQKQRIAIARALVRNPKILLLDE 1201
Query: 234 ATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLM 55
ATSALD+E ER VQ+ALD A GRTCIT+AHRLSSIQ++D I +++ GKV E G H +L+
Sbjct: 1202 ATSALDAECERTVQQALDAASSGRTCITVAHRLSSIQHADQIFFVENGKVVEEGTHQELV 1261
Query: 54 HQKGRYYKLIKKQDLA 7
G+Y LI+KQDL+
Sbjct: 1262 EFDGKYADLIRKQDLS 1277
Score = 284 bits (726), Expect = 1e-74
Identities = 182/529 (34%), Positives = 277/529 (51%), Gaps = 9/529 (1%)
Frame = -1
Query: 3534 VYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFDKNHSGTITTK 3355
+YI LGI I I F F V+ +R R + ++L QNA +FD + T T
Sbjct: 765 IYIALGIACLIVI--FSATFTFGWTAECVVDSLRLRAMRNMLYQNAEYFDTPSTSTAVTV 822
Query: 3354 LNDSMERIREGIGDKLGVLLRGFAMLIAAIV---VAYIYEWRLASMMLGVAPTCCICMSL 3184
S++ + + F ++A +V +A I+ W + +L V +
Sbjct: 823 TRISVDA--QTLKRSRSANDANFDNIVAILVLVTIAVIFNWPVG--LLAVKSPVTHFDAD 878
Query: 3183 LARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEK----GRKF 3016
+ R+ + K + G +A E + +RT+Q G+E Y +E +K
Sbjct: 879 IDRKYNAEVNKCALKQIVTGQLALEIVEQIRTIQLITGEEHFHRLYVQTIEDLLYLQKKS 938
Query: 3015 AVWKXXXXXXXXXXXXXXXXXXXGCG--MLYGAYLLKVGIITTPGDVFIVVMSMLLGAYF 2842
+ ++ G ++Y Y L P ++F S+ +
Sbjct: 939 SPYEAILFAVTSSFMFFSDMISYAAGIALIYYGYSL-------PQEIFTASWSIATSGWA 991
Query: 2841 LGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSR 2662
L ++S + + A ++ S+++ I+ ++ + + G V+F + F YP+R
Sbjct: 992 LIMVSGCLNTFVMASPASNSLFRIINTGSDMNSVDDGLRPA--ITGDVQFNKIKFSYPTR 1049
Query: 2661 KDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIE 2482
+LNGLNL G +VA+ G SG GKST + LL R Y +G +T+D + ++++
Sbjct: 1050 PQRNVLNGLNLAAYAGQTVAVTGPSGSGKSTVIALLERFYRFNSGQLTLDDNSITKISLR 1109
Query: 2481 WLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYDTLI 2302
+LR + +V QEPILF+ TI N+L+G G T + E CK+AN DFIE PKGYDT +
Sbjct: 1110 YLREQIALVGQEPILFSGTILENILLGTTGKTLSDVREACKIANIIDFIETSPKGYDTEV 1169
Query: 2301 GDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIM 2122
G+ GVQLSGGQKQR+AIAR L+R+PK+LLLDEATSALDA+ E VQ AL+ AS GRT I
Sbjct: 1170 GEHGVQLSGGQKQRIAIARALVRNPKILLLDEATSALDAECERTVQQALDAASSGRTCIT 1229
Query: 2121 IAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKA 1975
+AHRLS+I+ AD+I F E G +VE G H+ELV G+Y DL++ Q +
Sbjct: 1230 VAHRLSSIQHADQIFFVENGKVVEEGTHQELVEFDGKYADLIRKQDLSS 1278
>gi|39587899|emb|CAE67917.1| Hypothetical protein CBG13514
[Caenorhabditis briggsae]
Length = 1319
Score = 867 bits (2241), Expect = 0.0
Identities = 486/1269 (38%), Positives = 717/1269 (56%), Gaps = 33/1269 (2%)
Frame = -1
Query: 3723 VSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALL-----------VY 3577
V+IP L+RY + ++L +GTI AII+G P+++++ G+V+ A +
Sbjct: 60 VTIPQLYRYTTMTEKIMLLVGTIVAIITGAGLPLMSILQGQVSQAFINEQIVINTGNHTI 119
Query: 3576 PP-----TSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSV 3412
PP T F + + V+++ G+ I + I C+ + ++ ++R FV ++
Sbjct: 120 PPNGRNYTDSDFNHDVMQVVWLYAGMTIGMWAAGQITVTCYLYVAEQMNNRLRREFVKAI 179
Query: 3411 LRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLA 3232
LRQ+ WFD NHSGT+ TKL D++ER++EG GDK+G+ + + I +VA+ + W+L
Sbjct: 180 LRQDISWFDTNHSGTLATKLFDNLERVKEGTGDKIGMAFQYMSQFITGFIVAFTHSWKLT 239
Query: 3231 SMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVG 3052
+ML V P +C L+A+ M++ I+E + KAG + EE++ +RTV + NG +
Sbjct: 240 LVMLAVTPIQALCGFLIAKSMSTFAIRETVRYAKAGKVVEETISSIRTVVSLNGLRHELE 299
Query: 3051 RYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIV 2872
RY +E+ +K V K G + G + PGD+
Sbjct: 300 RYSTAVEEAKKSGVLKGLFLGISFGAMQATNFFSFALAFYIGVGWVHDGSLA-PGDMLTT 358
Query: 2871 VMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKF 2692
S+++G+ LGL P + VL A+ +A+SIY+ +DR P ID S AG++ + G +
Sbjct: 359 FSSVMMGSMALGLAGPQLAVLGTAQGAASSIYEVLDRKPVIDSSSSAGRKDMKIKGDITV 418
Query: 2691 ENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTID 2512
ENVHF YPSR+D IL G+NL V G +VALVG SGCGKST + LL R Y+ GN+TID
Sbjct: 419 ENVHFTYPSRQDVPILRGMNLRVNAGQTVALVGSSGCGKSTIISLLLRYYDVLKGNITID 478
Query: 2511 GTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIE 2332
G DVR++N+E+LR V +V QEP LFN TI N+ +G TRE MI CKMANA FI+
Sbjct: 479 GVDVRDINLEFLRTNVAVVSQEPALFNCTIEENIRLGREDITREEMIAACKMANAEKFIK 538
Query: 2331 KMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALN 2152
+P GY+TL+GD G QLSGGQKQR+AIAR L+R+PK+LLLDEATSALDA+SE IVQ AL+
Sbjct: 539 TLPAGYNTLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAESEGIVQQALD 598
Query: 2151 NASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKAD 1972
A+KGRTTI+IAHRLSTIR AD I+ + G +VE G+H L+ G Y+DLV AQ F
Sbjct: 599 KAAKGRTTIIIAHRLSTIRNADLIISCKNGQVVEVGDHRTLMAQEGLYYDLVTAQTF--- 655
Query: 1971 PXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEA-FRRGNSLNDSFSGSKRSXXXXXXX 1795
+D E FR+ + L+D + + S
Sbjct: 656 --------TDAVDASAGGKFSRENSIARQTSEHEGIFRQASELDDVLNRVRSSTMGSITN 707
Query: 1794 XXXXXXXXXXXXEDGQI------------TAGYLDIFKNAKGNYLYMFLGTVFALIRGLE 1651
+D +I +AK + L + +G A++ G
Sbjct: 708 GPVIEEKEQRIGKDALTRLKEELEENNAQRTNLFEILYHAKPHALSVAIGITAAIVGGFI 767
Query: 1650 LPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENL 1471
P ++ F F+ P ++ + + F + + + SE+L
Sbjct: 768 YPTYSVFFTSFINVFSGNP--DDILSQGHFWALMFLVLAAAQGICSFLMTFFMGIASESL 825
Query: 1470 SMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXX 1291
+M R + FRN+L Q +FD+P +A GK+ TRLA+D PN++ +D R V
Sbjct: 826 TMDLRNKLFRNVLSQHIGFFDSPQNASGKICTRLATDVPNLRTAIDFRFSTVITTLVSMI 885
Query: 1290 XXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQN-DDAGRIAIEIIENV 1114
Y WQ + F + + NV+ D+G+IAIE IENV
Sbjct: 886 AGIGLAFYYGWQMALLIVAILPIVGFGQYLRGRRFTGNNVKSASEFADSGKIAIEAIENV 945
Query: 1113 KTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRII 934
+T+Q L R + F+ + + + +K+ I+ ++Y S +Y + Y +G+ +I
Sbjct: 946 RTVQALAREDTFYYKFCSKLDVPHKEAIKEAFIQGLSYGCACSVLYLLNTCAYRMGLALI 1005
Query: 933 YQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDL-ME 757
+ + + A+ + + + YFPE+ KA A G++F ++ +K L +
Sbjct: 1006 LHRTMTPMRVLRVMYAITISTSTLGFATSYFPEYAKATFAGGIIFGMLKQKSEIDSLTLS 1065
Query: 756 GDRPEIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLER 577
G++ ++ G ++F+NV+F+YP+RP I+KGL ++ GQT+ALVGPSG GKST + +LER
Sbjct: 1066 GEKKKLSGKVIFKNVRFAYPERPQIEILKGLSFSVDPGQTLALVGPSGCGKSTVVALLER 1125
Query: 576 FYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGL--KDVPLEKI 403
FYD G + IDG +I+ L+ + R+Q+A+V QEP LF +I EN+ GL V + ++
Sbjct: 1126 FYDTLAGEVFIDGSEIKTLNPENTRSQIAIVSQEPTLFDCSIAENIVYGLDPTTVTMSRV 1185
Query: 402 NQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSA 223
+A +LAN + F++ LP G +T VG++G QLSGGQKQRIAIARALVR+PKILLLDEATSA
Sbjct: 1186 EEAAKLANIHNFISELPEGYETRVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSA 1245
Query: 222 LDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKG 43
LD+ESE+ VQEALDRAREGRTCI IAHRL++I N+D I ++ G + E G H+ LM Q+G
Sbjct: 1246 LDTESEKIVQEALDRAREGRTCIVIAHRLNTIMNADCIAVVNNGTIIEQGTHSVLMSQQG 1305
Query: 42 RYYKLIKKQ 16
YYKL +KQ
Sbjct: 1306 AYYKLTQKQ 1314
Score = 318 bits (816), Expect = 5e-85
Identities = 201/592 (33%), Positives = 314/592 (52%), Gaps = 6/592 (1%)
Frame = -1
Query: 3744 QQLEAQPVSIPGLFR--YGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPP 3571
++LE LF Y K L + IG AI+ G P ++ T+ + V+
Sbjct: 728 EELEENNAQRTNLFEILYHAKPHALSVAIGITAAIVGGFIYPTYSVF---FTSFINVFSG 784
Query: 3570 TSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGW 3391
++ + +FL + I +F+ + +R++ +VL Q+ G+
Sbjct: 785 NPDDILSQGHFWALMFLVLAAAQGICSFLMTFFMGIASESLTMDLRNKLFRNVLSQHIGF 844
Query: 3390 FD--KNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLG 3217
FD +N SG I T+L + +R I + ++ +IA I +A+ Y W++A +++
Sbjct: 845 FDSPQNASGKICTRLATDVPNLRTAIDFRFSTVITTLVSMIAGIGLAFYYGWQMALLIVA 904
Query: 3216 VAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAE 3037
+ P L R+ T +K +G IA E++ VRTVQA ++ ++ ++
Sbjct: 905 ILPIVGFGQYLRGRRFTGNNVKSASEFADSGKIAIEAIENVRTVQALAREDTFYYKFCSK 964
Query: 3036 LEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSML 2857
L+ K A+ + C G L+ + TP V V+ ++
Sbjct: 965 LDVPHKEAIKEAFIQGLSYGCACSVLYLLNTCAYRMGLALI-LHRTMTPMRVLRVMYAIT 1023
Query: 2856 LGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHF 2677
+ LG + + A + I+ + + +ID + +G++ + + G+V F+NV F
Sbjct: 1024 ISTSTLGFATSYFPEYAKATFAGGIIFGMLKQKSEIDSLTLSGEK-KKLSGKVIFKNVRF 1082
Query: 2676 RYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVR 2497
YP R +IL GL+ V+PG ++ALVG SGCGKST V LL R Y+ AG V IDG++++
Sbjct: 1083 AYPERPQIEILKGLSFSVDPGQTLALVGPSGCGKSTVVALLERFYDTLAGEVFIDGSEIK 1142
Query: 2496 ELNIEWLRNTVGIVQQEPILFNDTIHNNLLIG-NPGS-TRETMIEVCKMANAHDFIEKMP 2323
LN E R+ + IV QEP LF+ +I N++ G +P + T + E K+AN H+FI ++P
Sbjct: 1143 TLNPENTRSQIAIVSQEPTLFDCSIAENIVYGLDPTTVTMSRVEEAAKLANIHNFISELP 1202
Query: 2322 KGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNAS 2143
+GY+T +GD G QLSGGQKQR+AIAR L+R+PK+LLLDEATSALD +SE IVQ AL+ A
Sbjct: 1203 EGYETRVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEKIVQEALDRAR 1262
Query: 2142 KGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQ 1987
+GRT I+IAHRL+TI AD I G I+E G H L+ G Y+ L + Q
Sbjct: 1263 EGRTCIVIAHRLNTIMNADCIAVVNNGTIIEQGTHSVLMSQQGAYYKLTQKQ 1314
>gi|17541710|ref|NP_502413.1| P-GlycoProtein related (pgp-1)
[Caenorhabditis elegans]
gi|29429182|sp|P34712|MDR1_CAEEL Multidrug resistance protein 1
(P-glycoprotein A)
gi|7505559|pir||T23476 hypothetical protein K08E7.9 - Caenorhabditis
elegans
gi|3878418|emb|CAB01232.1| Hypothetical protein K08E7.9
[Caenorhabditis elegans]
Length = 1321
Score = 865 bits (2235), Expect = 0.0
Identities = 485/1260 (38%), Positives = 707/1260 (55%), Gaps = 24/1260 (1%)
Frame = -1
Query: 3723 VSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALL-----------VY 3577
VSIP L+RY + LLLFIGT+ A+I+G P+++++ G+V+ A + +
Sbjct: 60 VSIPQLYRYTTTLEKLLLFIGTLVAVITGAGLPLMSILQGKVSQAFINEQIVINNNGSTF 119
Query: 3576 PPTSKQFRNKANEN-----VYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSV 3412
PT + + E+ V+ + + + + I C+ + ++ ++R FV S+
Sbjct: 120 LPTGQNYTKTDFEHDVMNVVWSYAAMTVGMWAAGQITVTCYLYVAEQMNNRLRREFVKSI 179
Query: 3411 LRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLA 3232
LRQ WFD NHSGT+ TKL D++ER++EG GDK+G+ + + I +VA+ + W+L
Sbjct: 180 LRQEISWFDTNHSGTLATKLFDNLERVKEGTGDKIGMAFQYLSQFITGFIVAFTHSWQLT 239
Query: 3231 SMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVG 3052
+ML V P +C +A+ M++ I+E + KAG + EE++ +RTV + NG +
Sbjct: 240 LVMLAVTPIQALCGFAIAKSMSTFAIRETLRYAKAGKVVEETISSIRTVVSLNGLRYELE 299
Query: 3051 RYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIV 2872
RY +E+ +K V K G + G + GD+
Sbjct: 300 RYSTAVEEAKKAGVLKGLFLGISFGAMQASNFISFALAFYIGVGWVHDGSLNF-GDMLTT 358
Query: 2871 VMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKF 2692
S+++G+ LGL P + VL A+ +A+ IY+ +DR P ID SKAG++ + G +
Sbjct: 359 FSSVMMGSMALGLAGPQLAVLGTAQGAASGIYEVLDRKPVIDSSSKAGRKDMKIKGDITV 418
Query: 2691 ENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTID 2512
ENVHF YPSR D IL G+NL V G +VALVG SGCGKST + LL R Y+ G +TID
Sbjct: 419 ENVHFTYPSRPDVPILRGMNLRVNAGQTVALVGSSGCGKSTIISLLLRYYDVLKGKITID 478
Query: 2511 GTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIE 2332
G DVR++N+E+LR V +V QEP LFN TI N+ +G G TRE M+ CKMANA FI+
Sbjct: 479 GVDVRDINLEFLRKNVAVVSQEPALFNCTIEENISLGKEGITREEMVAACKMANAEKFIK 538
Query: 2331 KMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALN 2152
+P GY+TL+GD G QLSGGQKQR+AIAR L+R+PK+LLLDEATSALDA+SE IVQ AL+
Sbjct: 539 TLPNGYNTLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAESEGIVQQALD 598
Query: 2151 NASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQF--K 1978
A+KGRTTI+IAHRLSTIR AD I+ + G +VE G+H L+ G Y+DLV AQ F
Sbjct: 599 KAAKGRTTIIIAHRLSTIRNADLIISCKNGQVVEVGDHRALMAQQGLYYDLVTAQTFTDA 658
Query: 1977 ADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXX 1798
D T R +++ +G
Sbjct: 659 VDSAAEGKFSRENSVARQTSEHEGLSRQASEMDDIMNRVRSSTIGSITNGPVIDEKEERI 718
Query: 1797 XXXXXXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWV 1618
E+ +I +A+ + L +F+G A I G P ++ F
Sbjct: 719 GKDALSRLKQELEENNAQKTNLFEILYHARPHALSLFIGMSTATIGGFIYPTYSVFFTSF 778
Query: 1617 FEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRN 1438
F P + + + F + + + SE+L+ R + FRN
Sbjct: 779 MNVFAGNP--ADFLSQGHFWALMFLVLAAAQGICSFLMTFFMGIASESLTRDLRNKLFRN 836
Query: 1437 LLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCW 1258
+L Q +FD+P +A GK+ TRLA+D PN++ +D R V Y W
Sbjct: 837 VLSQHIGFFDSPQNASGKISTRLATDVPNLRTAIDFRFSTVITTLVSMVAGIGLAFFYGW 896
Query: 1257 QXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQN-DDAGRIAIEIIENVKTIQLLTRCEL 1081
Q +AF + + NV+ D+G+IAIE IENV+T+Q L R +
Sbjct: 897 QMALLIIAILPIVAFGQYLRGRRFTGKNVKSASEFADSGKIAIEAIENVRTVQALAREDT 956
Query: 1080 FFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDD-- 907
F++++ + +K+ I+ ++Y S +Y + Y +G+ +I +
Sbjct: 957 FYENFCEKLDIPHKEAIKEAFIQGLSYGCASSVLYLLNTCAYRMGLALIITDPPTMQPMR 1016
Query: 906 TFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDL-MEGDRPEIRGN 730
+ + A+ + + + YFPE+ KA A G++F ++ + + L + G++ ++ G
Sbjct: 1017 VLRVMYAITISTSTLGFATSYFPEYAKATFAGGIIFGMLRKISKIDSLSLAGEKKKLYGK 1076
Query: 729 ILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGAL 550
++F+NV+F+YP+RP I+KGL ++ GQT+ALVGPSG GKST + +LERFYD GG +
Sbjct: 1077 VIFKNVRFAYPERPEIEILKGLSFSVEPGQTLALVGPSGCGKSTVVALLERFYDTLGGEI 1136
Query: 549 RIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGL--KDVPLEKINQALELANA 376
IDG +I+ L+ H R+Q+A+V QEP LF +I EN+ GL V + ++ +A LAN
Sbjct: 1137 FIDGSEIKTLNPEHTRSQIAIVSQEPTLFDCSIAENIIYGLDPSSVTMAQVEEAARLANI 1196
Query: 375 NRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAV 196
+ F+A LP G +T VG++G QLSGGQKQRIAIARALVR+PKILLLDEATSALD+ESE+ V
Sbjct: 1197 HNFIAELPEGFETRVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEKVV 1256
Query: 195 QEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQ 16
QEALDRAREGRTCI IAHRL+++ N+D I + G + E G HTQLM +KG YYKL +KQ
Sbjct: 1257 QEALDRAREGRTCIVIAHRLNTVMNADCIAVVSNGTIIEKGTHTQLMSEKGAYYKLTQKQ 1316
Score = 328 bits (841), Expect = 6e-88
Identities = 206/608 (33%), Positives = 320/608 (51%), Gaps = 7/608 (1%)
Frame = -1
Query: 3789 EKILNYALCRGDIANQQLEAQPVSIPGLFR--YGKKFDYLLLFIGTICAIISGVSQPILA 3616
E+I AL R Q+LE LF Y + L LFIG A I G P +
Sbjct: 716 ERIGKDALSR---LKQELEENNAQKTNLFEILYHARPHALSLFIGMSTATIGGFIYPTYS 772
Query: 3615 LVSGRVTNALLVYPPTSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQM 3436
+ T+ + V+ F ++ + +FL + I +F+ + +
Sbjct: 773 VF---FTSFMNVFAGNPADFLSQGHFWALMFLVLAAAQGICSFLMTFFMGIASESLTRDL 829
Query: 3435 RHRFVYSVLRQNAGWFD--KNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIV 3262
R++ +VL Q+ G+FD +N SG I+T+L + +R I + ++ ++A I
Sbjct: 830 RNKLFRNVLSQHIGFFDSPQNASGKISTRLATDVPNLRTAIDFRFSTVITTLVSMVAGIG 889
Query: 3261 VAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQ 3082
+A+ Y W++A +++ + P L R+ T +K +G IA E++ VRTVQ
Sbjct: 890 LAFFYGWQMALLIIAILPIVAFGQYLRGRRFTGKNVKSASEFADSGKIAIEAIENVRTVQ 949
Query: 3081 AFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGI 2902
A ++ + +L+ K A+ + C G L+
Sbjct: 950 ALAREDTFYENFCEKLDIPHKEAIKEAFIQGLSYGCASSVLYLLNTCAYRMGLALIITDP 1009
Query: 2901 ITT-PGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGK 2725
T P V V+ ++ + LG + + A + I+ + ++ KID S AG+
Sbjct: 1010 PTMQPMRVLRVMYAITISTSTLGFATSYFPEYAKATFAGGIIFGMLRKISKIDSLSLAGE 1069
Query: 2724 RLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRL 2545
+ + + G+V F+NV F YP R + +IL GL+ VEPG ++ALVG SGCGKST V LL R
Sbjct: 1070 K-KKLYGKVIFKNVRFAYPERPEIEILKGLSFSVEPGQTLALVGPSGCGKSTVVALLERF 1128
Query: 2544 YEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIG-NPGSTRETMIE 2368
Y+ G + IDG++++ LN E R+ + IV QEP LF+ +I N++ G +P S +E
Sbjct: 1129 YDTLGGEIFIDGSEIKTLNPEHTRSQIAIVSQEPTLFDCSIAENIIYGLDPSSVTMAQVE 1188
Query: 2367 -VCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSAL 2191
++AN H+FI ++P+G++T +GD G QLSGGQKQR+AIAR L+R+PK+LLLDEATSAL
Sbjct: 1189 EAARLANIHNFIAELPEGFETRVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSAL 1248
Query: 2190 DAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGR 2011
D +SE +VQ AL+ A +GRT I+IAHRL+T+ AD I G I+E G H +L+ G
Sbjct: 1249 DTESEKVVQEALDRAREGRTCIVIAHRLNTVMNADCIAVVSNGTIIEKGTHTQLMSEKGA 1308
Query: 2010 YFDLVKAQ 1987
Y+ L + Q
Sbjct: 1309 YYKLTQKQ 1316
>gi|283551|pir||S27337 multidrug resistance protein A - Caenorhabditis
elegans
gi|6809|emb|CAA46190.1| P-glycoprotein A [Caenorhabditis elegans]
Length = 1321
Score = 864 bits (2233), Expect = 0.0
Identities = 485/1260 (38%), Positives = 707/1260 (55%), Gaps = 24/1260 (1%)
Frame = -1
Query: 3723 VSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALL-----------VY 3577
VSIP L+RY + LLLFIGT+ A+I+G P+++++ G+V+ A + +
Sbjct: 60 VSIPQLYRYTTTLEKLLLFIGTLVAVITGAGLPLMSILQGKVSQAFINEQIVINNNGSTF 119
Query: 3576 PPTSKQFRNKANEN-----VYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSV 3412
PT + + E+ V+ + + + + I C+ + ++ ++R FV S+
Sbjct: 120 LPTGQNYTKTDFEHDVMNVVWSYAAMTVGMWAAGQIIVTCYLYVAEQMNNRLRREFVKSI 179
Query: 3411 LRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLA 3232
LRQ WFD NHSGT+ TKL D++ER++EG GDK+G+ + + I +VA+ + W+L
Sbjct: 180 LRQEISWFDTNHSGTLATKLFDNLERVKEGTGDKIGMAFQYLSQFITGFIVAFTHSWQLT 239
Query: 3231 SMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVG 3052
+ML V P +C +A+ M++ I+E + KAG + EE++ +RTV + NG +
Sbjct: 240 LVMLAVTPIQALCGFAIAKSMSTFAIRETLRYAKAGKVVEETISSIRTVVSLNGLRYELE 299
Query: 3051 RYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIV 2872
RY +E+ +K V K G + G + GD+
Sbjct: 300 RYSTAVEEAKKAGVLKGLFLGISFGAMQASNFISFALAFYIGVGWVHDGSLNF-GDMLTT 358
Query: 2871 VMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKF 2692
S+++G+ LGL P + VL A+ +A+ IY+ +DR P ID SKAG++ + G +
Sbjct: 359 FSSVMMGSMALGLAGPQLAVLGTAQGAASGIYEVLDRKPVIDSSSKAGRKDMKIKGDITV 418
Query: 2691 ENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTID 2512
ENVHF YPSR D IL G+NL V G +VALVG SGCGKST + LL R Y+ G +TID
Sbjct: 419 ENVHFTYPSRPDVPILRGMNLRVNAGQTVALVGSSGCGKSTIISLLLRYYDVLKGKITID 478
Query: 2511 GTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIE 2332
G DVR++N+E+LR V +V QEP LFN TI N+ +G G TRE M+ CKMANA FI+
Sbjct: 479 GVDVRDINLEFLRKNVAVVSQEPALFNCTIEENISLGKEGITREEMVAACKMANAEKFIK 538
Query: 2331 KMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALN 2152
+P GY+TL+GD G QLSGGQKQR+AIAR L+R+PK+LLLDEATSALDA+SE IVQ AL+
Sbjct: 539 TLPNGYNTLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAESEGIVQQALD 598
Query: 2151 NASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQF--K 1978
A+KGRTTI+IAHRLSTIR AD I+ + G +VE G+H L+ G Y+DLV AQ F
Sbjct: 599 KAAKGRTTIIIAHRLSTIRNADLIISCKNGQVVEVGDHRALMAQQGLYYDLVTAQTFTDA 658
Query: 1977 ADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXX 1798
D T R +++ +G
Sbjct: 659 VDSAAEGKFSRENSVARQTSEHEGLSRQASEMDDIMNRVRSSTIGSITNGPVIDEKEERI 718
Query: 1797 XXXXXXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWV 1618
E+ +I +A+ + L +F+G A I G P ++ F
Sbjct: 719 GKDALSRLKQELEENNAQKTNLFEILYHARPHALSLFIGMSTATIGGFIYPTYSVFFTSF 778
Query: 1617 FEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRN 1438
F P + + + F + + + SE+L+ R + FRN
Sbjct: 779 MNVFAGNP--ADFLSQGHFWALMFLVLAAAQGICSFLMTFFMGIASESLTRDLRNKLFRN 836
Query: 1437 LLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCW 1258
+L Q +FD+P +A GK+ TRLA+D PN++ +D R V Y W
Sbjct: 837 VLSQHIGFFDSPQNASGKISTRLATDVPNLRTAIDFRFSTVITTLVSMVAGIGLAFFYGW 896
Query: 1257 QXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQN-DDAGRIAIEIIENVKTIQLLTRCEL 1081
Q +AF + + NV+ D+G+IAIE IENV+T+Q L R +
Sbjct: 897 QMALLIIAILPIVAFGQYLRGRRFTGKNVKSASEFADSGKIAIEAIENVRTVQALAREDT 956
Query: 1080 FFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDD-- 907
F++++ + +K+ I+ ++Y S +Y + Y +G+ +I +
Sbjct: 957 FYENFCEKLDIPHKEAIKEAFIQGLSYGCASSVLYLLNTCAYRMGLALIITDPPTMQPMR 1016
Query: 906 TFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDL-MEGDRPEIRGN 730
+ + A+ + + + YFPE+ KA A G++F ++ + + L + G++ ++ G
Sbjct: 1017 VLRVMYAITISTSTLGFATSYFPEYAKATFAGGIIFGMLRKISKIDSLSLAGEKKKLYGK 1076
Query: 729 ILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGAL 550
++F+NV+F+YP+RP I+KGL ++ GQT+ALVGPSG GKST + +LERFYD GG +
Sbjct: 1077 VIFKNVRFAYPERPEIEILKGLSFSVEPGQTLALVGPSGCGKSTVVALLERFYDTLGGEI 1136
Query: 549 RIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGL--KDVPLEKINQALELANA 376
IDG +I+ L+ H R+Q+A+V QEP LF +I EN+ GL V + ++ +A LAN
Sbjct: 1137 FIDGSEIKTLNPEHTRSQIAIVSQEPTLFDCSIAENIIYGLDPSSVTMAQVEEAARLANI 1196
Query: 375 NRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAV 196
+ F+A LP G +T VG++G QLSGGQKQRIAIARALVR+PKILLLDEATSALD+ESE+ V
Sbjct: 1197 HNFIAELPEGFETRVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEKVV 1256
Query: 195 QEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQ 16
QEALDRAREGRTCI IAHRL+++ N+D I + G + E G HTQLM +KG YYKL +KQ
Sbjct: 1257 QEALDRAREGRTCIVIAHRLNTVMNADCIAVVSNGTIIEKGTHTQLMSEKGAYYKLTQKQ 1316
Score = 328 bits (841), Expect = 6e-88
Identities = 206/608 (33%), Positives = 320/608 (51%), Gaps = 7/608 (1%)
Frame = -1
Query: 3789 EKILNYALCRGDIANQQLEAQPVSIPGLFR--YGKKFDYLLLFIGTICAIISGVSQPILA 3616
E+I AL R Q+LE LF Y + L LFIG A I G P +
Sbjct: 716 ERIGKDALSR---LKQELEENNAQKTNLFEILYHARPHALSLFIGMSTATIGGFIYPTYS 772
Query: 3615 LVSGRVTNALLVYPPTSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQM 3436
+ T+ + V+ F ++ + +FL + I +F+ + +
Sbjct: 773 VF---FTSFMNVFAGNPADFLSQGHFWALMFLVLAAAQGICSFLMTFFMGIASESLTRDL 829
Query: 3435 RHRFVYSVLRQNAGWFD--KNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIV 3262
R++ +VL Q+ G+FD +N SG I+T+L + +R I + ++ ++A I
Sbjct: 830 RNKLFRNVLSQHIGFFDSPQNASGKISTRLATDVPNLRTAIDFRFSTVITTLVSMVAGIG 889
Query: 3261 VAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQ 3082
+A+ Y W++A +++ + P L R+ T +K +G IA E++ VRTVQ
Sbjct: 890 LAFFYGWQMALLIIAILPIVAFGQYLRGRRFTGKNVKSASEFADSGKIAIEAIENVRTVQ 949
Query: 3081 AFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGI 2902
A ++ + +L+ K A+ + C G L+
Sbjct: 950 ALAREDTFYENFCEKLDIPHKEAIKEAFIQGLSYGCASSVLYLLNTCAYRMGLALIITDP 1009
Query: 2901 ITT-PGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGK 2725
T P V V+ ++ + LG + + A + I+ + ++ KID S AG+
Sbjct: 1010 PTMQPMRVLRVMYAITISTSTLGFATSYFPEYAKATFAGGIIFGMLRKISKIDSLSLAGE 1069
Query: 2724 RLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRL 2545
+ + + G+V F+NV F YP R + +IL GL+ VEPG ++ALVG SGCGKST V LL R
Sbjct: 1070 K-KKLYGKVIFKNVRFAYPERPEIEILKGLSFSVEPGQTLALVGPSGCGKSTVVALLERF 1128
Query: 2544 YEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIG-NPGSTRETMIE 2368
Y+ G + IDG++++ LN E R+ + IV QEP LF+ +I N++ G +P S +E
Sbjct: 1129 YDTLGGEIFIDGSEIKTLNPEHTRSQIAIVSQEPTLFDCSIAENIIYGLDPSSVTMAQVE 1188
Query: 2367 -VCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSAL 2191
++AN H+FI ++P+G++T +GD G QLSGGQKQR+AIAR L+R+PK+LLLDEATSAL
Sbjct: 1189 EAARLANIHNFIAELPEGFETRVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSAL 1248
Query: 2190 DAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGR 2011
D +SE +VQ AL+ A +GRT I+IAHRL+T+ AD I G I+E G H +L+ G
Sbjct: 1249 DTESEKVVQEALDRAREGRTCIVIAHRLNTVMNADCIAVVSNGTIIEKGTHTQLMSEKGA 1308
Query: 2010 YFDLVKAQ 1987
Y+ L + Q
Sbjct: 1309 YYKLTQKQ 1316
>gi|17569145|ref|NP_509902.1| P-GlycoProtein related (pgp-4)
[Caenorhabditis elegans]
gi|7503247|pir||T22090 hypothetical protein F42E11.1 - Caenorhabditis
elegans
gi|3877005|emb|CAA91463.1| Hypothetical protein F42E11.1
[Caenorhabditis elegans]
Length = 1266
Score = 862 bits (2228), Expect = 0.0
Identities = 486/1251 (38%), Positives = 723/1251 (56%), Gaps = 12/1251 (0%)
Frame = -1
Query: 3732 AQPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQ-- 3559
+Q S+ LFR+ DYLLL G + + +G P +L+ +TN L+ +
Sbjct: 24 SQGNSLSNLFRHSGCADYLLLLGGLVLSAANGALLPFNSLIFEGITNVLMKGEAQWQNGT 83
Query: 3558 -----FRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAG 3394
F + ++ +G+ + + C R + +R + SVLRQ+A
Sbjct: 84 FDYDTFSSGIQHYCLLYFLLGVLMFTCTYFSNACLFTMAERRLYCIRKHLLQSVLRQDAK 143
Query: 3393 WFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGV 3214
WFD+N G +T K++ +E+I++GIGDK+GVL+ G A I+ + + + W+L +ML
Sbjct: 144 WFDENTVGGLTQKMSSGIEKIKDGIGDKIGVLVSGIATFISGVALGFYMCWQLTLVMLVT 203
Query: 3213 APTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAEL 3034
P M L A+ + T E+ AG +A E + G+RTV AFN Q + RY A+L
Sbjct: 204 VPLQLGSMYLSAKHLNRATKNEMSAYSSAGGMANEVIAGIRTVIAFNAQPFEIERYGAQL 263
Query: 3033 EKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLL 2854
K RK + K YGA L G+ T+ G F V +++L
Sbjct: 264 AKARKMGIRKAIVLALCSAMPLFLMFVLMAGAFWYGAILTSYGVATS-GTTFGVFWAVIL 322
Query: 2853 GAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFR 2674
G LG +PHM + AR++ I++ ID P+I+ + G+R V G++ F+N+ F
Sbjct: 323 GTRRLGEAAPHMGAITGARLAVNDIFKVIDHEPEINCTKQEGRRPDKVNGKLVFDNIQFT 382
Query: 2673 YPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRE 2494
YP+R D KIL G++ V PG ++ALVGHSGCGKSTS+GLL R Y AG++ +DG + +
Sbjct: 383 YPTRPDVKILKGVSFEVNPGETIALVGHSGCGKSTSIGLLMRFYNQCAGSIKLDGIPIED 442
Query: 2493 LNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGY 2314
NI+WLR+T+GIVQQEPI+F T+ N+ +G+ T + + C+ ANAHDFI K+ +GY
Sbjct: 443 YNIQWLRSTIGIVQQEPIIFLATVAENVRMGDDSITDKDIENACRQANAHDFIGKLSEGY 502
Query: 2313 DTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGR 2134
+T+IG G VQLSGGQKQRVAIAR ++R P++LLLDEATSALD +SE +VQ+AL+ AS+GR
Sbjct: 503 NTVIGAGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGR 562
Query: 2133 TTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKADPXXXXX 1954
TT+ IAHRLSTIR A KI+ F++G+I E G H++L+R G Y ++V+AQ+ +
Sbjct: 563 TTLCIAHRLSTIRNASKILVFDQGLIPERGIHDQLIRQNGIYANMVRAQEIE------KA 616
Query: 1953 XXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSL---NDSFSGSKRSXXXXXXXXXXX 1783
D D+ E R+ SL + FS S S
Sbjct: 617 KDDTTQDDDELVEEDNYSISRRLSTSEEELRKSKSLLRDSTRFSQSMLS-VTSQVPDWEM 675
Query: 1782 XXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFT 1603
E+G + A +DIF+ AK + + + +F LIRG+ PA ++++G +F+
Sbjct: 676 ESAREEMIEEGAMEASMMDIFRFAKPEKMNIVIALIFTLIRGITWPAFSVVYGQLFK--V 733
Query: 1602 FVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQD 1423
F G + ++ + F + V + S L E +S R R+ F+N++ QD
Sbjct: 734 FAEGGEDLPVNALISSLWFVLLAVTSAVTTFISGSLLGKTGETMSSRLRMDVFKNIMQQD 793
Query: 1422 ASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXX 1243
A+YFD+P H G L +RLA+D+ N++A +D R+ +V + W
Sbjct: 794 ATYFDDPKHNVGNLTSRLATDSQNVQAAIDHRLAEVLNGVVSLFTGIAVAFWFGWSMAPI 853
Query: 1242 XXXXXXXLAFVMIGLAYKISLMNVEQIQND-DAGRIAIEIIENVKTIQLLTRCELFFDHY 1066
L +A + + +++ +A RI E I N KT+Q LT+ E F +
Sbjct: 854 GLITALLLVIAQSAVAQYLKYRGPKDMESAIEASRIVTESISNWKTVQALTKQEYMFHAF 913
Query: 1065 QTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIA 886
+SK ++ KG+ ++++++L SF + Y G+ +I + F+ I A
Sbjct: 914 TAASKNPRKRAFTKGLWQSLSFALAGSFFLWNFAIAYMFGLWLISNNWTTPFAVFQVIEA 973
Query: 885 MMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDL-MEGDRPEIRGNILFENVK 709
+ + +++VM +A YFPE+V+A+ +AG++F +I +K + + + G+ P+IRG+I + V
Sbjct: 974 LNMASMSVMMAASYFPEYVRARISAGIMFTMIRQKAKIDNRGLTGETPDIRGDISMKGVY 1033
Query: 708 FSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDI 529
F+YP R Q I+ +A G+TVALVGPSG GKST+I ++ER+YD GA++ID DI
Sbjct: 1034 FAYPNRNRQLILNNFNMSAQFGETVALVGPSGCGKSTSIQLIERYYDAICGAVKIDDHDI 1093
Query: 528 RKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGLKDVPLEKINQALELANANRFLANLPA 349
R +S+ HLR +ALVGQEP LF TIREN+ GL++V E++ +A LAN + F+ NLP
Sbjct: 1094 RDISVKHLRHNIALVGQEPTLFNLTIRENITYGLENVSQEQVEKAATLANIHSFVENLPE 1153
Query: 348 GIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRARE 169
G DT VG GG+LSGGQKQRIAIARA+VR+PKILLLDEATSALD+ESE+ VQEALD+AR
Sbjct: 1154 GYDTSVGASGGRLSGGQKQRIAIARAIVRNPKILLLDEATSALDTESEKIVQEALDKARL 1213
Query: 168 GRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQ 16
GRTC+ IAHRLS+IQN+D I+ GK E G H L+ ++G YY+L++KQ
Sbjct: 1214 GRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 1264
Score = 278 bits (711), Expect = 8e-73
Identities = 182/580 (31%), Positives = 294/580 (50%), Gaps = 15/580 (2%)
Frame = -1
Query: 1704 NYLYMFLGTVFALIRGLELPALALIFG------------WVFEGFTFVPYGGRMMHRMAM 1561
+YL + G V + G LP +LIF W F + + + H +
Sbjct: 40 DYLLLLGGLVLSAANGALLPFNSLIFEGITNVLMKGEAQWQNGTFDYDTFSSGIQHYCLL 99
Query: 1560 AVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKL 1381
+ + +FS ++ LF + L R +++L QDA +FD + G L
Sbjct: 100 YFLLGVLMFTCTYFS---NACLFTMAERRLYC-IRKHLLQSVLRQDAKWFDE--NTVGGL 153
Query: 1380 ITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIG 1201
+++S IK + ++ + CWQ M
Sbjct: 154 TQKMSSGIEKIKDGIGDKIGVLVSGIATFISGVALGFYMCWQLTLVMLVTVPLQLGSMYL 213
Query: 1200 LAYKISLMNVEQIQN-DDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKK 1024
A ++ ++ AG +A E+I ++T+ + Y + ++ ++K
Sbjct: 214 SAKHLNRATKNEMSAYSSAGGMANEVIAGIRTVIAFNAQPFEIERYGAQLAKARKMGIRK 273
Query: 1023 GMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQY 844
++ A+ ++ M+ +M + G + G +S TF A++LG + +A +
Sbjct: 274 AIVLALCSAMPLFLMFVLMAGAFWYGAILTSYGVATSGTTFGVFWAVILGTRRLGEAAPH 333
Query: 843 FPEFVKAKTAAGMLFNIIYRKPRTG-DLMEGDRPE-IRGNILFENVKFSYPQRPLQPIMK 670
A+ A +F +I +P EG RP+ + G ++F+N++F+YP RP I+K
Sbjct: 334 MGAITGARLAVNDIFKVIDHEPEINCTKQEGRRPDKVNGKLVFDNIQFTYPTRPDVKILK 393
Query: 669 GLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMA 490
G+ + G+T+ALVG SG GKST+IG+L RFY+ G++++DG I ++ LR+ +
Sbjct: 394 GVSFEVNPGETIALVGHSGCGKSTSIGLLMRFYNQCAGSIKLDGIPIEDYNIQWLRSTIG 453
Query: 489 LVGQEPRLFAGTIRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQL 310
+V QEP +F T+ ENV +G + + I A ANA+ F+ L G +T +G QL
Sbjct: 454 IVQQEPIIFLATVAENVRMGDDSITDKDIENACRQANAHDFIGKLSEGYNTVIGAGAVQL 513
Query: 309 SGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSS 130
SGGQKQR+AIARA+VR P+ILLLDEATSALD+ESER VQ ALD+A EGRT + IAHRLS+
Sbjct: 514 SGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCIAHRLST 573
Query: 129 IQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQDL 10
I+N+ I+ D+G + E G H QL+ Q G Y +++ Q++
Sbjct: 574 IRNASKILVFDQGLIPERGIHDQLIRQNGIYANMVRAQEI 613
>gi|39594783|emb|CAE70651.1| Hypothetical protein CBG17356
[Caenorhabditis briggsae]
Length = 1265
Score = 860 bits (2223), Expect = 0.0
Identities = 482/1246 (38%), Positives = 716/1246 (56%), Gaps = 11/1246 (0%)
Frame = -1
Query: 3720 SIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQ------ 3559
S+ LFR+ DYLLL G + + SG P +L+ +TN L+ +
Sbjct: 28 SLSNLFRHSDCLDYLLLLGGIVFSSASGALLPFNSLIFEGITNVLMQGQSEWQNGTFAYD 87
Query: 3558 -FRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFDK 3382
F ++ +G+F+ + +I C R + +R + SVLRQ+A WFD+
Sbjct: 88 TFSTGIRHYCLLYFLLGVFMFLCTYISNACLYTMAERRLYCIRKHLLRSVLRQDAQWFDE 147
Query: 3381 NHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTC 3202
N G +T K++ +E+I++GIGDK+GVL G A I+ +++ + W+L +ML P
Sbjct: 148 NTVGGLTQKMSSGIEKIKDGIGDKIGVLFSGAATFISGVLLGFYMCWQLTLVMLITVPLQ 207
Query: 3201 CICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGR 3022
M + A+ + T E+ AG +A E + G+RTV AFN Q + RY +L + R
Sbjct: 208 LGQMYMSAKHLNRATKNEMSAYSSAGGMANEVIAGIRTVIAFNAQPFEISRYADKLAEAR 267
Query: 3021 KFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYF 2842
+ + K YGA L GI T+ G F V ++LLG
Sbjct: 268 QMGIRKSIVLASCSAVPLVLMFVLMAGAFWYGAILTSFGIATS-GTTFGVFWAVLLGTRR 326
Query: 2841 LGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSR 2662
LG +PHM +L AR++ I++ ID P+I+ + G+R + + G++ F+N+ F YP+R
Sbjct: 327 LGEAAPHMGAILGARLAINDIFKVIDNEPEINCTKETGRRPEKINGKLNFDNIEFTYPTR 386
Query: 2661 KDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIE 2482
D KIL G++ V PG +VALVGHSGCGKSTS+GLL R Y AG + +DG + + NI+
Sbjct: 387 PDVKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGTIKLDGVPIEDYNIQ 446
Query: 2481 WLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYDTLI 2302
WLR+T+GIVQQEPI+F T+ N+ +G+ T + + + C+ ANAHDFI + GY+T+I
Sbjct: 447 WLRSTIGIVQQEPIIFLATVSENIRMGDNSITDKDIEDACRQANAHDFIGHLSDGYNTII 506
Query: 2301 GDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIM 2122
G G VQLSGGQKQRVAIAR ++R P++LLLDEATSALD +SE +VQ+AL+ AS+GRTT+
Sbjct: 507 GAGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQAALDKASQGRTTLC 566
Query: 2121 IAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKADPXXXXXXXXX 1942
IAHRLSTIR A+KI+ F++G+IVE G H++L+R G Y +V+AQ+ +
Sbjct: 567 IAHRLSTIRNANKILVFDQGLIVEKGTHDQLIRQNGIYASMVRAQEIE-------RAKED 619
Query: 1941 EIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXXX--XXXXXXXXX 1768
+ DD+ + R+ SL + +S
Sbjct: 620 TVVEDDSLEEETQSISRRLSTSEDEVRKSKSLLRDSARLSQSMLSVTSQVPDWEVEIARE 679
Query: 1767 XXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYG 1588
E+G + A +DIF+ AK + + + LIRG+ PA ++++G +F+ F G
Sbjct: 680 EMFEEGAMEASMMDIFRFAKPEKWNVIIALIVTLIRGITWPAFSVVYGQLFK--VFAEGG 737
Query: 1587 GRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFD 1408
+ ++ + F + + S L E +S R R+ F+N++ QDASYFD
Sbjct: 738 EDLPTNAFVSSLWFILLAFTSGITTFISGSLLGKTGETMSSRLRLNVFKNIMQQDASYFD 797
Query: 1407 NPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXX 1228
P H G L RLA+D+ N++A +D R+ +V + W
Sbjct: 798 EPKHNVGNLTARLATDSQNVQAAIDHRLAEVLNGVISLFAGIAVAFWFGWSMAPIGLLTA 857
Query: 1227 XXLAFVMIGLAYKISLMNVEQIQND-DAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSK 1051
L +A + + +++ +A RI E I N KT+Q LT+ E + + T+SK
Sbjct: 858 LLLVIAQSSVAQYLKYRGPKDMESAIEASRIVTESISNWKTVQALTKQEYMYGAFTTASK 917
Query: 1050 QQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGA 871
+ ++ KG+ ++++++L SF + Y G+ +I + F+ I A+ + +
Sbjct: 918 KPRQRAFAKGLWQSLSFALAGSFFLWNFAIAYMFGLWLISNNWTTPFAVFQVIEALNMAS 977
Query: 870 VAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDL-MEGDRPEIRGNILFENVKFSYPQ 694
++VM +A YFPE+V+A+ +AG++F +I +K + + G+ P I+G+I V F+YP
Sbjct: 978 MSVMMAASYFPEYVRARISAGIMFTMIRQKSAIDNRGLTGETPLIKGDISMRGVYFAYPN 1037
Query: 693 RPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSL 514
R Q I+ +A GQTVALVGPSG GKST I ++ER+YD G++RID D+R +S+
Sbjct: 1038 RKRQLILNNFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDAVCGSVRIDDTDVRDISV 1097
Query: 513 FHLRTQMALVGQEPRLFAGTIRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTD 334
HLR +ALVGQEP LF +IREN+ GL++V E+I +A +LAN + F+ +LP G DT
Sbjct: 1098 KHLRDNIALVGQEPTLFNLSIRENITYGLENVSQEQIEEAAKLANIHNFVISLPEGYDTS 1157
Query: 333 VGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCI 154
VG GG+LSGGQKQRIAIARA+VRDPKILLLDEATSALDSESE+ VQEALD+AR GRTC+
Sbjct: 1158 VGASGGRLSGGQKQRIAIARAIVRDPKILLLDEATSALDSESEKIVQEALDKARLGRTCV 1217
Query: 153 TIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQ 16
IAHRLS+IQN+D I+ GK E G H L+ ++G YY+L++KQ
Sbjct: 1218 VIAHRLSTIQNADKIIVCRNGKAIEEGTHQSLLARRGLYYRLVEKQ 1263
Score = 325 bits (834), Expect = 4e-87
Identities = 198/584 (33%), Positives = 316/584 (53%), Gaps = 2/584 (0%)
Frame = -1
Query: 3732 AQPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFR 3553
A S+ +FR+ K + ++ I I +I G++ P ++V G++ V+ +
Sbjct: 686 AMEASMMDIFRFAKPEKWNVI-IALIVTLIRGITWPAFSVVYGQLFK---VFAEGGEDLP 741
Query: 3552 NKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFD--KN 3379
A + F+ + IT FI + +++R ++++Q+A +FD K+
Sbjct: 742 TNAFVSSLWFILLAFTSGITTFISGSLLGKTGETMSSRLRLNVFKNIMQQDASYFDEPKH 801
Query: 3378 HSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCC 3199
+ G +T +L + ++ I +L +L G L A I VA+ + W +A + L A
Sbjct: 802 NVGNLTARLATDSQNVQAAIDHRLAEVLNGVISLFAGIAVAFWFGWSMAPIGLLTALLLV 861
Query: 3198 ICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRK 3019
I S +A+ + K++ +A I ES+ +TVQA QE M G + +K R+
Sbjct: 862 IAQSSVAQYLKYRGPKDMESAIEASRIVTESISNWKTVQALTKQEYMYGAFTTASKKPRQ 921
Query: 3018 FAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFL 2839
A K ++G +L+ TTP VF V+ ++ + + +
Sbjct: 922 RAFAKGLWQSLSFALAGSFFLWNFAIAYMFGLWLISNNW-TTPFAVFQVIEALNMASMSV 980
Query: 2838 GLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRK 2659
+ + + + AR+SA ++ I + ID G+ + G + V+F YP+RK
Sbjct: 981 MMAASYFPEYVRARISAGIMFTMIRQKSAIDNRGLTGET-PLIKGDISMRGVYFAYPNRK 1039
Query: 2658 DAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEW 2479
ILN N+ G +VALVG SGCGKST++ L+ R Y+ G+V ID TDVR+++++
Sbjct: 1040 RQLILNNFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDAVCGSVRIDDTDVRDISVKH 1099
Query: 2478 LRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYDTLIG 2299
LR+ + +V QEP LFN +I N+ G ++E + E K+AN H+F+ +P+GYDT +G
Sbjct: 1100 LRDNIALVGQEPTLFNLSIRENITYGLENVSQEQIEEAAKLANIHNFVISLPEGYDTSVG 1159
Query: 2298 DGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMI 2119
G +LSGGQKQR+AIAR ++RDPK+LLLDEATSALD++SE IVQ AL+ A GRT ++I
Sbjct: 1160 ASGGRLSGGQKQRIAIARAIVRDPKILLLDEATSALDSESEKIVQEALDKARLGRTCVVI 1219
Query: 2118 AHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQ 1987
AHRLSTI+ ADKI+ G +E G H+ L+ G Y+ LV+ Q
Sbjct: 1220 AHRLSTIQNADKIIVCRNGKAIEEGTHQSLLARRGLYYRLVEKQ 1263
Score = 279 bits (714), Expect = 3e-73
Identities = 188/580 (32%), Positives = 296/580 (50%), Gaps = 15/580 (2%)
Frame = -1
Query: 1704 NYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGRM-MHRMAMAVIAFAS---- 1540
+YL + G VF+ G LP +LIF EG T V G+ A F++
Sbjct: 40 DYLLLLGGIVFSSASGALLPFNSLIF----EGITNVLMQGQSEWQNGTFAYDTFSTGIRH 95
Query: 1539 -------VGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKL 1381
+GV ++ S+ ++E R R++L QDA +FD + G L
Sbjct: 96 YCLLYFLLGVFMFLCTYISNACLYTMAERRLYCIRKHLLRSVLRQDAQWFDE--NTVGGL 153
Query: 1380 ITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIG 1201
+++S IK + ++ + CWQ M
Sbjct: 154 TQKMSSGIEKIKDGIGDKIGVLFSGAATFISGVLLGFYMCWQLTLVMLITVPLQLGQMYM 213
Query: 1200 LAYKISLMNVEQIQN-DDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKK 1024
A ++ ++ AG +A E+I ++T+ Y + ++ ++K
Sbjct: 214 SAKHLNRATKNEMSAYSSAGGMANEVIAGIRTVIAFNAQPFEISRYADKLAEARQMGIRK 273
Query: 1023 GMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQY 844
++ A ++ M+ +M + G + G +S TF A++LG + +A +
Sbjct: 274 SIVLASCSAVPLVLMFVLMAGAFWYGAILTSFGIATSGTTFGVFWAVLLGTRRLGEAAPH 333
Query: 843 FPEFVKAKTAAGMLFNIIYRKPRTGDLME-GDRPE-IRGNILFENVKFSYPQRPLQPIMK 670
+ A+ A +F +I +P E G RPE I G + F+N++F+YP RP I+K
Sbjct: 334 MGAILGARLAINDIFKVIDNEPEINCTKETGRRPEKINGKLNFDNIEFTYPTRPDVKILK 393
Query: 669 GLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMA 490
G+ + G+TVALVG SG GKST+IG+L RFY+ G +++DG I ++ LR+ +
Sbjct: 394 GVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGTIKLDGVPIEDYNIQWLRSTIG 453
Query: 489 LVGQEPRLFAGTIRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQL 310
+V QEP +F T+ EN+ +G + + I A ANA+ F+ +L G +T +G QL
Sbjct: 454 IVQQEPIIFLATVSENIRMGDNSITDKDIEDACRQANAHDFIGHLSDGYNTIIGAGAVQL 513
Query: 309 SGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSS 130
SGGQKQR+AIARA+VR P+ILLLDEATSALD+ESER VQ ALD+A +GRT + IAHRLS+
Sbjct: 514 SGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQAALDKASQGRTTLCIAHRLST 573
Query: 129 IQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQDL 10
I+N++ I+ D+G + E G H QL+ Q G Y +++ Q++
Sbjct: 574 IRNANKILVFDQGLIVEKGTHDQLIRQNGIYASMVRAQEI 613
>gi|39594784|emb|CAE70652.1| Hypothetical protein CBG17357
[Caenorhabditis briggsae]
Length = 1268
Score = 846 bits (2186), Expect = 0.0
Identities = 485/1252 (38%), Positives = 712/1252 (56%), Gaps = 21/1252 (1%)
Frame = -1
Query: 3708 LFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKANENV- 3532
+FR DY L+ G I + ++G P +L+ + NAL+ Q++N
Sbjct: 34 VFRDSDWRDYALVAGGIILSAVNGALVPFNSLIFEGIANALM---EGEAQYQNGTLNMPW 90
Query: 3531 -----------YIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFD 3385
Y +LG+ +F+ ++ C C R + +R ++ SVLRQ+A WFD
Sbjct: 91 FSSEIKFFCLRYFYLGLALFLC--SYCANACLYTLCERRLHCIRKHYLKSVLRQDAKWFD 148
Query: 3384 KNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPT 3205
++ G +T K++ +E+I++GIGDK+GV++ G A I+ + + + W+L +ML P
Sbjct: 149 QHTIGGLTQKMSSGIEKIKDGIGDKIGVIVGGVATFISGVSLGFYMCWQLTLVMLITVPL 208
Query: 3204 CCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKG 3025
M L A+ + T E+ AG +A E + G+RTV AFN Q + RY +LE+
Sbjct: 209 QLGSMYLSAKHLNRATKNEMSAYSNAGGMANEVIAGIRTVMAFNAQPFEINRYSQQLEEA 268
Query: 3024 RKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAY 2845
RK V K YGA L G +++ G VF V ++L+G
Sbjct: 269 RKMGVRKAMILAICTSFPLMLMFTCMAVAFWYGATLAAAGAVSS-GAVFAVFWAVLIGTR 327
Query: 2844 FLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPS 2665
+G +PH+ + AR++ I++ ID P+I S GK + G++ F+ + F YP+
Sbjct: 328 RIGEAAPHLGAITGARLAIHDIFKVIDHEPEIKCTSSDGKIPDKIQGKLSFDGIEFTYPT 387
Query: 2664 RKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNI 2485
R D KIL G++ V PG +VALVGHSGCGKSTS+GLL R Y AG + +DG + E NI
Sbjct: 388 RPDLKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQGAGMIKLDGVPIHEYNI 447
Query: 2484 EWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYDTL 2305
WLR+T+GIVQQEPI+F T+ N+ +G+ T + + E C+MANAH+FI K+ Y+T+
Sbjct: 448 RWLRSTIGIVQQEPIIFVATVAENIRMGDDLITDDDIEEACRMANAHEFICKLSDKYNTV 507
Query: 2304 IGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTI 2125
IG G VQLSGGQKQRVAIAR ++R P++LLLDEATSALD +SE +VQ+AL+ ASKGRTT+
Sbjct: 508 IGAGAVQLSGGQKQRVAIARAIVRRPQILLLDEATSALDTESERMVQAALDKASKGRTTL 567
Query: 2124 MIAHRLSTIREADKIVFFEKGVIVEAGNHEELV-RLGGRYFDLVKAQQFKADPXXXXXXX 1948
IAHRLSTI+ A KI+ F++G+I E G H+EL+ + G Y +V AQ+ +
Sbjct: 568 CIAHRLSTIKNASKILVFDQGLIAERGTHDELISKEDGIYASMVAAQEIERAKEDTTLD- 626
Query: 1947 XXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXXXXXXXXXXXX 1768
D +D ++ + + +
Sbjct: 627 ----DEEDEKDHRMFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPEWEIESARE 682
Query: 1767 XXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYG 1588
E+G + A +DIFK A + + VF LIRGL PA ++++G +F + G
Sbjct: 683 EMIEEGAMEASLVDIFKFASPEGRNIIIALVFTLIRGLTWPAFSIVYGQLFR---ILSAG 739
Query: 1587 G------RMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQ 1426
G +++ + ++AF S S L S L E +S R R+ FRN++ Q
Sbjct: 740 GDDVSIKALLNSLWFLLLAFTS-----GISTLVSGGLLGKAGETMSGRLRMDVFRNIMQQ 794
Query: 1425 DASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXX 1246
DASYFD+P H G L +RLA+DAPN++A +D R+ +V Y W
Sbjct: 795 DASYFDDPKHNVGALTSRLATDAPNVQAAIDQRLAEVLTGVVSLFCGVSVAFFYGWNMAP 854
Query: 1245 XXXXXXXXLAFVMIGLAYKISLMNVEQIQND-DAGRIAIEIIENVKTIQLLTRCELFFDH 1069
L V +A + + + +A R+ E I N KT+Q LT+ E +D
Sbjct: 855 IGLATALLLVVVQSAVAQYLKFRGQRDMDSAIEASRLVTESISNWKTVQSLTKQEYMYDS 914
Query: 1068 YQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGII 889
+ +SK R + +G+ ++++++L SF+ + Y G+ +I G + F+ I
Sbjct: 915 FVAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNGWSTPYTVFQVIE 974
Query: 888 AMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDL-MEGDRPEIRGNILFENV 712
A+ + +++VM +A YFPE+V+A+ +AG++F +I ++ + + GD P I+G+I V
Sbjct: 975 ALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQRSVIDNRGLTGDTPPIKGDISMREV 1034
Query: 711 KFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQD 532
F+YP R Q ++ TA GQTVALVGPSG GKST I ++ER+YD G +++DG D
Sbjct: 1035 YFAYPNRRRQLVLDSFNMTAKFGQTVALVGPSGCGKSTTIQLIERYYDALSGKIKVDGCD 1094
Query: 531 IRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGLKDVPLEKINQALELANANRFLANLP 352
IR++S+ HLR +ALVGQEP LF TIREN+ GL+ + E++ +A LAN + F+ LP
Sbjct: 1095 IREISVKHLRDNIALVGQEPTLFNLTIRENITYGLEKISQEEVEKAATLANIHTFVMGLP 1154
Query: 351 AGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAR 172
G DT VG GG+LSGGQKQR+AIARA+VRDPKILLLDEATSALD+ESE+ VQEALD+AR
Sbjct: 1155 EGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKAR 1214
Query: 171 EGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQ 16
GRTCI IAHRLS+IQN+D I+ GK E G H L+ ++G YY+L++KQ
Sbjct: 1215 LGRTCIVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 1266
Score = 266 bits (681), Expect = 2e-69
Identities = 177/588 (30%), Positives = 299/588 (50%), Gaps = 13/588 (2%)
Frame = -1
Query: 1734 YLDIFKNAKG-NYLYMFLGTVFALIRGLELPALALIFGWV----FEGFTFVPYGGRMMHR 1570
+ D+F+++ +Y + G + + + G +P +LIF + EG G M
Sbjct: 31 FFDVFRDSDWRDYALVAGGIILSAVNGALVPFNSLIFEGIANALMEGEAQYQNGTLNMPW 90
Query: 1569 MAMAV----IAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNP 1402
+ + + + +G+ ++ ++ + E R +++L QDA +FD
Sbjct: 91 FSSEIKFFCLRYFYLGLALFLCSYCANACLYTLCERRLHCIRKHYLKSVLRQDAKWFDQ- 149
Query: 1401 AHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXX 1222
H G L +++S IK + ++ + CWQ
Sbjct: 150 -HTIGGLTQKMSSGIEKIKDGIGDKIGVIVGGVATFISGVSLGFYMCWQLTLVMLITVPL 208
Query: 1221 LAFVMIGLAYKISLMNVEQIQN-DDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQ 1045
M A ++ ++ +AG +A E+I ++T+ + Y ++
Sbjct: 209 QLGSMYLSAKHLNRATKNEMSAYSNAGGMANEVIAGIRTVMAFNAQPFEINRYSQQLEEA 268
Query: 1044 KRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVA 865
++ ++K MI AI S M+ M + G + G SS F A+++G
Sbjct: 269 RKMGVRKAMILAICTSFPLMLMFTCMAVAFWYGATLAAAGAVSSGAVFAVFWAVLIGTRR 328
Query: 864 VMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTG-DLMEGDRPE-IRGNILFENVKFSYPQR 691
+ +A + A+ A +F +I +P +G P+ I+G + F+ ++F+YP R
Sbjct: 329 IGEAAPHLGAITGARLAIHDIFKVIDHEPEIKCTSSDGKIPDKIQGKLSFDGIEFTYPTR 388
Query: 690 PLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLF 511
P I+KG+ + G+TVALVG SG GKST+IG+L RFY+ G +++DG I + ++
Sbjct: 389 PDLKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQGAGMIKLDGVPIHEYNIR 448
Query: 510 HLRTQMALVGQEPRLFAGTIRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTDV 331
LR+ + +V QEP +F T+ EN+ +G + + I +A +ANA+ F+ L +T +
Sbjct: 449 WLRSTIGIVQQEPIIFVATVAENIRMGDDLITDDDIEEACRMANAHEFICKLSDKYNTVI 508
Query: 330 GEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCIT 151
G QLSGGQKQR+AIARA+VR P+ILLLDEATSALD+ESER VQ ALD+A +GRT +
Sbjct: 509 GAGAVQLSGGQKQRVAIARAIVRRPQILLLDEATSALDTESERMVQAALDKASKGRTTLC 568
Query: 150 IAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQK-GRYYKLIKKQDL 10
IAHRLS+I+N+ I+ D+G + E G H +L+ ++ G Y ++ Q++
Sbjct: 569 IAHRLSTIKNASKILVFDQGLIAERGTHDELISKEDGIYASMVAAQEI 616
>gi|17558664|ref|NP_507487.1| P-GlycoProtein related (pgp-9)
[Caenorhabditis elegans]
gi|7497530|pir||T19982 hypothetical protein C47A10.1 - Caenorhabditis
elegans
gi|3875004|emb|CAB03973.1| Hypothetical protein C47A10.1
[Caenorhabditis elegans]
gi|3879215|emb|CAB07855.1| Hypothetical protein C47A10.1
[Caenorhabditis elegans]
Length = 1294
Score = 843 bits (2177), Expect = 0.0
Identities = 494/1272 (38%), Positives = 706/1272 (54%), Gaps = 32/1272 (2%)
Frame = -1
Query: 3735 EAQP---VSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRV-----TNALLV 3580
EA P +SI L+RY D L+L +G I + +GV P+++++ G V T +
Sbjct: 22 EAPPPPKISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIF 81
Query: 3579 YPPTSK---------QFRNKANENV--YIFLGIGIFISITNFIQYMCFQHCCTRVMAQMR 3433
P S +F ++ +N Y++LG GIF + F+Q CF C ++ + R
Sbjct: 82 LDPNSTASEKAAARAEFSHEVIQNCLKYVYLGCGIFAA--GFLQASCFMVICEKLSNRFR 139
Query: 3432 HRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAY 3253
+F +SV+RQ W+DKN SGT++ KL D++ER+REG GDK+G+ + A I VA+
Sbjct: 140 RQFFHSVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAF 199
Query: 3252 IYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFN 3073
Y+W L +M+ ++P IC LA+ + + KE AG IAEE L +RTV AFN
Sbjct: 200 TYDWLLTLIMMSLSPFMMICGLFLAKLLATAATKEAKQYAVAGGIAEEVLTSIRTVIAFN 259
Query: 3072 GQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITT 2893
GQE RYE LE G+K + K G + G + +
Sbjct: 260 GQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLES 319
Query: 2892 PGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQN 2713
G V V S+++G+ LG + A +AAS+Y+ IDR+P+ID YS G+
Sbjct: 320 -GTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSK 378
Query: 2712 VVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPE 2533
+ GR+ V F YP+R D KIL G++L +PG +VALVG SGCGKST + LL R Y P+
Sbjct: 379 ISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPD 438
Query: 2532 AGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMA 2353
AG + ID + + NI++LR VG+V QEP LFN +I N+ G + E + K A
Sbjct: 439 AGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEA 498
Query: 2352 NAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSES 2173
NA DFI+ P+G +TL+GD GVQ+SGGQKQR+AIAR L+R+PK+LLLDEATSALDA+SES
Sbjct: 499 NAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESES 558
Query: 2172 IVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVK 1993
IVQSAL NAS+GRTTI+IAHRLST+R ADKI+ + G ++E G HE L+ G Y +LV
Sbjct: 559 IVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVH 618
Query: 1992 AQQFKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEA----FRRGNSLNDSFSGS 1825
AQ F D+DD F+ S D G+
Sbjct: 619 AQVF--------------ADVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDEKPGA 664
Query: 1824 KRSXXXXXXXXXXXXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELP 1645
+ E+G + A I + A+ ++Y+F + ALI+G +P
Sbjct: 665 PPA---PEAAEKEIKRLKKELEEEGAVKANLFKILRYARPEWIYIFFAIIAALIQGAVMP 721
Query: 1644 ALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSM 1465
A +L F + F+ P +M + F + S L LF V +E L+M
Sbjct: 722 AFSLFFSQIINVFS-NPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTM 780
Query: 1464 RFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXX 1285
R R + +RN+L QDA+YFD P H+PG++ TRLA+DAPNIK+ +D R+ +
Sbjct: 781 RIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGG 840
Query: 1284 XXXXXIYCWQXXXXXXXXXXXLAFVMIGLA----YKISLMNVEQIQNDDAGRIAIEIIEN 1117
Y WQ F+ +G A Y + + ++AG+ A+E IEN
Sbjct: 841 LGIAFYYGWQ---MAFLVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIEN 897
Query: 1116 VKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRI 937
++T+Q LT ++ + + + K +I + Y S +F + G+ +
Sbjct: 898 IRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFL 957
Query: 936 IYQGD--KSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPR-TGD 766
I+ + ++ + + A+ + +A YFPE++KA AAG++FN++ +PR G
Sbjct: 958 IFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGM 1017
Query: 765 LMEGDRPEIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGM 586
G P++ G + V F YP+RP PI++GL GQT+ALVGPSG GKST I +
Sbjct: 1018 TSSGTYPQLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISL 1077
Query: 585 LERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGLK--DVPL 412
LER YD GA+ +D D+R+++ HLR +ALV QEP LF +IREN+ GL+ +
Sbjct: 1078 LERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTH 1137
Query: 411 EKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEA 232
E+I A AN ++F+ LP G +T VGEKG QLSGGQKQRIAIARAL+R+PKILLLDEA
Sbjct: 1138 EQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEA 1197
Query: 231 TSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMH 52
TSALD+ESE+ VQ ALD A + RTCI +AHRLS+I N+ I+ + G+V E G H +L+
Sbjct: 1198 TSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIA 1257
Query: 51 QKGRYYKLIKKQ 16
++G Y+ L +KQ
Sbjct: 1258 KRGAYFALTQKQ 1269
Score = 297 bits (761), Expect = 1e-78
Identities = 195/585 (33%), Positives = 296/585 (50%), Gaps = 21/585 (3%)
Frame = -1
Query: 1698 LYMFLGTVFALIRGLELPALALIFGWVFEGFTFV---------------PYGGRMMHRMA 1564
L + +G + + G+ LP +++I G V + F + H +
Sbjct: 44 LMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTASEKAAARAEFSHEVI 103
Query: 1563 MAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGK 1384
+ + +G G++ + + F V+ E LS RFR Q F +++ Q+ +++D + G
Sbjct: 104 QNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQEIAWYDK--NTSGT 161
Query: 1383 LITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMI 1204
L +L + ++ ++ Y W F+MI
Sbjct: 162 LSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDW---LLTLIMMSLSPFMMI 218
Query: 1203 GLAYKISLMNV----EQIQNDDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRS 1036
+ L+ E Q AG IA E++ +++T+ E Y+ + + K++
Sbjct: 219 CGLFLAKLLATAATKEAKQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKT 278
Query: 1035 ELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMN 856
+KK + + +Y C + VG +Y G S ++M+G++A+
Sbjct: 279 GIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFFSVMMGSMALGQ 338
Query: 855 SAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLM-EGDRP-EIRGNILFENVKFSYPQRPLQ 682
+ Q F A AA L+ +I R P EG P +I G I V+F+YP R
Sbjct: 339 AGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNKVEFTYPTRADV 398
Query: 681 PIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLR 502
I+KG+ A GQTVALVG SG GKST I +L+RFY+ G + ID I ++ +LR
Sbjct: 399 KILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLR 458
Query: 501 TQMALVGQEPRLFAGTIRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGEK 322
+ +V QEP LF +I +N+ G DV E I +AL+ ANA F+ P G++T VG++
Sbjct: 459 QLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEGLNTLVGDR 518
Query: 321 GGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAH 142
G Q+SGGQKQRIAIARALVR+PKILLLDEATSALD+ESE VQ AL+ A GRT I IAH
Sbjct: 519 GVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVIAH 578
Query: 141 RLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQDLA 7
RLS+++N+D I+ + G+V E G H L+ QKG Y++L+ Q A
Sbjct: 579 RLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFA 623
>gi|17569143|ref|NP_509901.1| P-GlycoProtein related (pgp-3)
[Caenorhabditis elegans]
gi|29429184|sp|P34713|MDR3_CAEEL Multidrug resistance protein 3
(P-glycoprotein C)
gi|7511155|pir||T22094 hypothetical protein ZK455.7 - Caenorhabditis
elegans
gi|3877009|emb|CAA91467.1| Hypothetical protein ZK455.7
[Caenorhabditis elegans]
gi|3881645|emb|CAA91495.1| C. elegans PGP-3 protein (corresponding
sequence ZK455.7) [Caenorhabditis elegans]
Length = 1268
Score = 842 bits (2176), Expect = 0.0
Identities = 482/1252 (38%), Positives = 711/1252 (56%), Gaps = 21/1252 (1%)
Frame = -1
Query: 3708 LFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKANENV- 3532
+FR DY+L G I + ++G P +L+ + NAL+ Q++N
Sbjct: 34 VFRDADYKDYILFSGGLILSAVNGALVPFNSLIFEGIANALM---EGESQYQNGTINMPW 90
Query: 3531 -----------YIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFD 3385
Y +LG+ +F+ ++ C C R + +R +++ SVLRQ+A WFD
Sbjct: 91 FSSEIKMFCLRYFYLGVALFLC--SYFANSCLYTLCERRLHCIRKKYLKSVLRQDAKWFD 148
Query: 3384 KNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPT 3205
+ G +T K++ +E+I++GIGDK+GVL+ G A I+ + + + W+L +M+ P
Sbjct: 149 ETTIGGLTQKMSSGIEKIKDGIGDKVGVLVGGVATFISGVSIGFYMCWQLTLVMMITVPL 208
Query: 3204 CCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKG 3025
M L A+ + T E+ AG +A E + G+RTV AFN Q + RY +L +
Sbjct: 209 QLGSMYLSAKHLNRATKNEMSAYSNAGGMANEVIAGIRTVMAFNAQPFEINRYAHQLNEA 268
Query: 3024 RKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAY 2845
R+ + K YGA L G +++ G VF V ++L+G
Sbjct: 269 RRMGIRKAIILAICTAFPLMLMFTCMAVAFWYGATLAAAGAVSS-GAVFAVFWAVLIGTR 327
Query: 2844 FLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPS 2665
LG +PH+ + AR++ I++ ID P+I S GK + + G++ F+ + F YP+
Sbjct: 328 RLGEAAPHLGAITGARLAIHDIFKVIDHEPEIKCTSSEGKIPEKIQGKLTFDGIEFTYPT 387
Query: 2664 RKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNI 2485
R + KIL G++ V PG +VALVGHSGCGKSTS+GLL R Y AG + +DG ++E NI
Sbjct: 388 RPELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNI 447
Query: 2484 EWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYDTL 2305
WLR+T+GIVQQEPI+F T+ N+ +G+ T + + E CKMANAH+FI K+ YDT+
Sbjct: 448 RWLRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTV 507
Query: 2304 IGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTI 2125
IG G VQLSGGQKQRVAIAR ++R P++LLLDEATSALD +SE +VQ+AL+ AS+GRTT+
Sbjct: 508 IGAGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTL 567
Query: 2124 MIAHRLSTIREADKIVFFEKGVIVEAGNHEELV-RLGGRYFDLVKAQQFKADPXXXXXXX 1948
IAHRLSTIR A KI+ F++G+I E G H+EL+ + G Y +VKAQ+ +
Sbjct: 568 CIAHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIE-----RAKED 622
Query: 1947 XXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXXXXXXXXXXXX 1768
D +D ++ + + +
Sbjct: 623 TTLDDEEDEKTHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPEWEIENARE 682
Query: 1767 XXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYG 1588
E+G + A DIFK A + + VF LIRG PA ++++G +F+ + G
Sbjct: 683 EMIEEGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFK---ILSAG 739
Query: 1587 G------RMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQ 1426
G +++ + ++AF S L S L E +S R R+ FRN++ Q
Sbjct: 740 GDDVSIKALLNSLWFILLAFTG-----GISTLISGSLLGKAGETMSGRLRMDVFRNIMQQ 794
Query: 1425 DASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXX 1246
DASYFD+ H G L +RLA+DAPN++A +D R+ +V Y W
Sbjct: 795 DASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAP 854
Query: 1245 XXXXXXXXLAFVMIGLAYKISLMNVEQIQND-DAGRIAIEIIENVKTIQLLTRCELFFDH 1069
L V +A + + + +A R+ E I N KT+Q LT+ E +D
Sbjct: 855 IGLATALLLVVVQSSVAQYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDA 914
Query: 1068 YQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGII 889
+ +SK R + +G+ ++++++L SF+ + Y G+ +I + F+ I
Sbjct: 915 FTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIE 974
Query: 888 AMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDL-MEGDRPEIRGNILFENV 712
A+ + +++VM +A YFPE+V+A+ +AG++F +I +K + + GD P I+GNI V
Sbjct: 975 ALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGV 1034
Query: 711 KFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQD 532
F+YP R Q ++ G +A GQTVALVGPSG GKST I ++ER+YD G+++ID D
Sbjct: 1035 YFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSD 1094
Query: 531 IRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGLKDVPLEKINQALELANANRFLANLP 352
IR LS+ HLR +ALVGQEP LF TIREN+ GL+++ +++ +A LAN + F+ LP
Sbjct: 1095 IRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLP 1154
Query: 351 AGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAR 172
G DT VG GG+LSGGQKQR+AIARA+VRDPKILLLDEATSALD+ESE+ VQEALD+AR
Sbjct: 1155 DGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKAR 1214
Query: 171 EGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQ 16
GRTC+ IAHRLS+IQN+D I+ GK E G H L+ ++G YY+L++KQ
Sbjct: 1215 LGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 1266
Score = 303 bits (777), Expect = 2e-80
Identities = 185/584 (31%), Positives = 305/584 (51%), Gaps = 2/584 (0%)
Frame = -1
Query: 3732 AQPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFR 3553
A S+ +F+Y + + I + +I G + P ++V G++ L
Sbjct: 689 AMEASLFDIFKYASP-EMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSA---GGDDVS 744
Query: 3552 NKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFD--KN 3379
KA N F+ + I+ I + ++R ++++Q+A +FD ++
Sbjct: 745 IKALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRH 804
Query: 3378 HSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCC 3199
+ G++T++L ++ I +L +L G L + VA+ Y W +A + L A
Sbjct: 805 NVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGLATALLLV 864
Query: 3198 ICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRK 3019
+ S +A+ + +++ +A + ES+ +TVQA QE M + A + +
Sbjct: 865 VVQSSVAQYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHR 924
Query: 3018 FAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFL 2839
A+ + ++G +L+ +TP VF V+ ++ + + +
Sbjct: 925 RAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNW-STPYTVFQVIEALNMASMSV 983
Query: 2838 GLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRK 2659
L + + + AR+SA ++ I + ID G + G + V+F YP+R+
Sbjct: 984 MLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDT-PTIKGNINMRGVYFAYPNRR 1042
Query: 2658 DAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEW 2479
+L+G N+ G +VALVG SGCGKST++ L+ R Y+ G+V ID +D+R+L+++
Sbjct: 1043 RQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKH 1102
Query: 2478 LRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYDTLIG 2299
LR+ + +V QEP LFN TI N+ G T++ + + +AN H F+ +P GYDT +G
Sbjct: 1103 LRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYDTSVG 1162
Query: 2298 DGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMI 2119
G +LSGGQKQRVAIAR ++RDPK+LLLDEATSALD +SE IVQ AL+ A GRT ++I
Sbjct: 1163 ASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVI 1222
Query: 2118 AHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQ 1987
AHRLSTI+ ADKI+ G +E G H+ L+ G Y+ LV+ Q
Sbjct: 1223 AHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 1266
Score = 274 bits (701), Expect = 1e-71
Identities = 187/589 (31%), Positives = 305/589 (51%), Gaps = 14/589 (2%)
Frame = -1
Query: 1734 YLDIFKNAK-GNYLYMFLGTVFALIRGLELPALALIFGWV----FEGFTFVPYGGRMM-- 1576
+ D+F++A +Y+ G + + + G +P +LIF + EG + G M
Sbjct: 31 FFDVFRDADYKDYILFSGGLILSAVNGALVPFNSLIFEGIANALMEGESQYQNGTINMPW 90
Query: 1575 --HRMAMAVIAFASVGVGVWF-SQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDN 1405
+ M + + +GV ++ S A+S L+ + L R + +++L QDA +FD
Sbjct: 91 FSSEIKMFCLRYFYLGVALFLCSYFANSCLYTLCERRLHC-IRKKYLKSVLRQDAKWFDE 149
Query: 1404 PAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXX 1225
G L +++S IK + ++ + CWQ
Sbjct: 150 TTI--GGLTQKMSSGIEKIKDGIGDKVGVLVGGVATFISGVSIGFYMCWQLTLVMMITVP 207
Query: 1224 XLAFVMIGLAYKISLMNVEQIQN-DDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQ 1048
M A ++ ++ +AG +A E+I ++T+ + Y +
Sbjct: 208 LQLGSMYLSAKHLNRATKNEMSAYSNAGGMANEVIAGIRTVMAFNAQPFEINRYAHQLNE 267
Query: 1047 QKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAV 868
+R ++K +I AI + M+ M + G + G SS F A+++G
Sbjct: 268 ARRMGIRKAIILAICTAFPLMLMFTCMAVAFWYGATLAAAGAVSSGAVFAVFWAVLIGTR 327
Query: 867 AVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTG-DLMEGDRPE-IRGNILFENVKFSYPQ 694
+ +A + A+ A +F +I +P EG PE I+G + F+ ++F+YP
Sbjct: 328 RLGEAAPHLGAITGARLAIHDIFKVIDHEPEIKCTSSEGKIPEKIQGKLTFDGIEFTYPT 387
Query: 693 RPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSL 514
RP I+KG+ + G+TVALVG SG GKST+IG+L RFY+ G +++DG I++ ++
Sbjct: 388 RPELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNI 447
Query: 513 FHLRTQMALVGQEPRLFAGTIRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTD 334
LR+ + +V QEP +F T+ EN+ +G + + I +A ++ANA+ F+ L DT
Sbjct: 448 RWLRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTV 507
Query: 333 VGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCI 154
+G QLSGGQKQR+AIARA+VR P+ILLLDEATSALD+ESER VQ ALD+A EGRT +
Sbjct: 508 IGAGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTL 567
Query: 153 TIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQ-KGRYYKLIKKQDL 10
IAHRLS+I+N+ I+ D+G + E G H +L+ + G Y ++K Q++
Sbjct: 568 CIAHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEI 616
>gi|39585393|emb|CAE61715.1| Hypothetical protein CBG05664
[Caenorhabditis briggsae]
Length = 1294
Score = 832 bits (2148), Expect = 0.0
Identities = 486/1272 (38%), Positives = 703/1272 (55%), Gaps = 30/1272 (2%)
Frame = -1
Query: 3735 EAQP---VSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVY---- 3577
EA P +SI LFRY D ++L +G + + +G+ P+++++ G V+ +
Sbjct: 23 EAPPPPKISIFQLFRYTSTMDRIMLIVGILVSCATGLGLPLMSIIMGNVSQNFVEIGTIL 82
Query: 3576 -----PPTSKQFRNKANENV------YIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRH 3430
P K+ ++ + +V Y++LG GIF + IQ CF C + + R
Sbjct: 83 MNSTDPAVIKKAKDDFSHDVIQNCLQYVYLGAGIFAA--GMIQASCFLIICENLSNRFRR 140
Query: 3429 RFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYI 3250
F YSV+R W+DKN SGT++ KL D++ER+REG GDK+G+ + A + VA+
Sbjct: 141 EFFYSVMRHEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFLGGFAVAFS 200
Query: 3249 YEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNG 3070
Y+W L +M+ ++P IC LA+ + + KE AG IAEE L +RTV AFNG
Sbjct: 201 YDWLLTLIMMSLSPFMMICGLFLAKLLATAATKEAKQYAVAGGIAEEVLTSIRTVIAFNG 260
Query: 3069 QEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTP 2890
QE RYE L GRK + K G + G + +
Sbjct: 261 QEYECKRYEEALSHGRKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYNGRLDS- 319
Query: 2889 GDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNV 2710
G V V S+++G+ LG + A +AAS+Y+ IDR P+ID YS G + +
Sbjct: 320 GTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRTPEIDAYSTKGVTPEKI 379
Query: 2709 VGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEA 2530
GR+K +N+ F YP+R D +IL ++L +PG ++ALVG SGCGKST + LL R Y P+A
Sbjct: 380 SGRIKIQNIEFTYPTRPDVQILKDVSLEAQPGQTIALVGSSGCGKSTIIQLLQRFYNPDA 439
Query: 2529 GNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMAN 2350
G + ID + + NI++LR VG+V QEP LFN +I N+ G + + K AN
Sbjct: 440 GKIYIDDIAIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRADVDSDAINRALKEAN 499
Query: 2349 AHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESI 2170
A DFI+ P+G +TL+GD GVQ+SGGQKQR+AIAR L+R+PK+LLLDEATSALDA+SES+
Sbjct: 500 ALDFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESV 559
Query: 2169 VQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKA 1990
VQ+AL+NAS+GRTTI+IAHRLST+R ADKI+ + G ++E G H+ L+ G Y +LV A
Sbjct: 560 VQAALDNASRGRTTIVIAHRLSTVRNADKIIVMKAGKVMEIGTHDTLIEQKGLYHELVHA 619
Query: 1989 QQFKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXX 1810
Q F D+D+ + R+G+ + S ++
Sbjct: 620 QVF--------------ADVDEKPRAKKEAERRLSRQT--SARKGSLIKTQESQAEEKSG 663
Query: 1809 ---XXXXXXXXXXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPAL 1639
E+G + A I K A+ ++Y+F + ALI+G +PA
Sbjct: 664 PPPAPEPAEKEIKRLRKELEEEGAVKANLFKILKYARPEWMYIFFAIIAALIQGAVMPAF 723
Query: 1638 ALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRF 1459
+L F + F+ P +M + F + S L F V +E L+MR
Sbjct: 724 SLFFSQIINVFS-NPDREQMKKDGHFWALMFLVLAAIQGTSMLFQCAFFGVAAEGLTMRV 782
Query: 1458 RVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXX 1279
R + +RN+L QDA+YFD P H+PG++ TRLA+DAPNIK+ +D R+ V
Sbjct: 783 RSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSVFNAIASVGGGLG 842
Query: 1278 XXXIYCWQXXXXXXXXXXXLAFVMIGLA----YKISLMNVEQIQNDDAGRIAIEIIENVK 1111
Y WQ F+ +G A Y + + +++G+ A+E IEN++
Sbjct: 843 IAFYYGWQ---MALLVMAIFPFMAVGQALVIKYHGGSATADAKEMENSGKTAMEAIENIR 899
Query: 1110 TIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIY 931
T+Q LT ++ + + + K +I + Y S +F + G+ +I+
Sbjct: 900 TVQALTLQTKLYNIFCSHLDSPHSGNVSKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIF 959
Query: 930 QGD--KSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPR-TGDLM 760
+ S + K + A+ + +A YFPE++KA AAG++FN++ +PR G
Sbjct: 960 NQNVLMSPEHVLKVLFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTN 1019
Query: 759 EGDRPEIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLE 580
G P + G + V F YP+RP PI++GL GQT+ALVGPSG GKST I +LE
Sbjct: 1020 AGTLPALSGEVKLNKVFFRYPERPAVPILQGLDVHVKPGQTLALVGPSGCGKSTVISLLE 1079
Query: 579 RFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGLK--DVPLEK 406
R YD GA+ ID ++R+++ HLR +ALV QEP LF +IREN+ GL+ + E
Sbjct: 1080 RLYDPLEGAVTIDNNNLRQMNPKHLRKHIALVSQEPILFDTSIRENIIYGLQPGEYTEEA 1139
Query: 405 INQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATS 226
I A E AN ++F++ LP G T VGEKG QLSGGQKQRIAIARAL+R+PKILLLDEATS
Sbjct: 1140 IAVACEKANIHKFISELPDGYQTRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATS 1199
Query: 225 ALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQK 46
ALD+ESE+ VQ ALD A + RTCI +AHRLS+I N+ I+ + GKV E G H +LM ++
Sbjct: 1200 ALDTESEKQVQIALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGKVVEQGTHLELMAKR 1259
Query: 45 GRYYKLIKKQDL 10
G Y+ L +KQ +
Sbjct: 1260 GAYFALTQKQSI 1271
Score = 326 bits (835), Expect = 3e-87
Identities = 200/593 (33%), Positives = 314/593 (52%), Gaps = 7/593 (1%)
Frame = -1
Query: 3744 QQLEAQPVSIPGLFRYGK--KFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPP 3571
++LE + LF+ K + +++ +F I A+I G P +L ++ N P
Sbjct: 680 KELEEEGAVKANLFKILKYARPEWMYIFFAIIAALIQGAVMPAFSLFFSQIINVFS--NP 737
Query: 3570 TSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGW 3391
+Q + + +FL + + Q F + ++R + +VLRQ+A +
Sbjct: 738 DREQMKKDGHFWALMFLVLAAIQGTSMLFQCAFFGVAAEGLTMRVRSKVYRNVLRQDATY 797
Query: 3390 FD--KNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLG 3217
FD K+ G ITT+L I+ I +LG + A + + +A+ Y W++A +++
Sbjct: 798 FDMPKHSPGRITTRLATDAPNIKSAIDYRLGSVFNAIASVGGGLGIAFYYGWQMALLVMA 857
Query: 3216 VAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAE 3037
+ P + +L+ + + + + +G A E++ +RTVQA Q ++ + +
Sbjct: 858 IFPFMAVGQALVIKYHGGSATADAKEMENSGKTAMEAIENIRTVQALTLQTKLYNIFCSH 917
Query: 3036 LEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLL-KVGIITTPGDVFIVVMSM 2860
L+ V K +G +L+ ++ +P V V+ ++
Sbjct: 918 LDSPHSGNVSKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFNQNVLMSPEHVLKVLFAI 977
Query: 2859 LLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVH 2680
+G + + + A +A I+ ++ P+ID + AG L + G VK V
Sbjct: 978 SFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTNAGT-LPALSGEVKLNKVF 1036
Query: 2679 FRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDV 2500
FRYP R IL GL++ V+PG ++ALVG SGCGKST + LL RLY+P G VTID ++
Sbjct: 1037 FRYPERPAVPILQGLDVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTIDNNNL 1096
Query: 2499 RELNIEWLRNTVGIVQQEPILFNDTIHNNLLIG-NPGS-TRETMIEVCKMANAHDFIEKM 2326
R++N + LR + +V QEPILF+ +I N++ G PG T E + C+ AN H FI ++
Sbjct: 1097 RQMNPKHLRKHIALVSQEPILFDTSIRENIIYGLQPGEYTEEAIAVACEKANIHKFISEL 1156
Query: 2325 PKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNA 2146
P GY T +G+ G QLSGGQKQR+AIAR LIR+PK+LLLDEATSALD +SE VQ AL+ A
Sbjct: 1157 PDGYQTRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQIALDAA 1216
Query: 2145 SKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQ 1987
+K RT I++AHRLSTI A I+ + G +VE G H EL+ G YF L + Q
Sbjct: 1217 AKDRTCIVVAHRLSTIVNAGCIMVVKNGKVVEQGTHLELMAKRGAYFALTQKQ 1269
Score = 303 bits (777), Expect = 2e-80
Identities = 199/586 (33%), Positives = 303/586 (50%), Gaps = 22/586 (3%)
Frame = -1
Query: 1698 LYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFAS------- 1540
+ + +G + + GL LP +++I G V + F V G +M+ AVI A
Sbjct: 45 IMLIVGILVSCATGLGLPLMSIIMGNVSQNF--VEIGTILMNSTDPAVIKKAKDDFSHDV 102
Query: 1539 ---------VGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPG 1387
+G G++ + + + F ++ ENLS RFR + F +++ + +++D + G
Sbjct: 103 IQNCLQYVYLGAGIFAAGMIQASCFLIICENLSNRFRREFFYSVMRHEIAWYDK--NTSG 160
Query: 1386 KLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVM 1207
L +L + ++ ++ Y W F+M
Sbjct: 161 TLSNKLFDNLERVREGTGDKVGLAFQMMAQFLGGFAVAFSYDW---LLTLIMMSLSPFMM 217
Query: 1206 IGLAYKISLMNV----EQIQNDDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKR 1039
I + L+ E Q AG IA E++ +++T+ E Y+ + ++
Sbjct: 218 ICGLFLAKLLATAATKEAKQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEEALSHGRK 277
Query: 1038 SELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVM 859
+ +KK + + +Y C + VG +Y G S ++M+G++A+
Sbjct: 278 TGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYNGRLDSGTVLTVFFSVMMGSMALG 337
Query: 858 NSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLM-EGDRPE-IRGNILFENVKFSYPQRPL 685
+ Q F A AA L+ +I R P +G PE I G I +N++F+YP RP
Sbjct: 338 QAGQQFATIGTALGAAASLYEVIDRTPEIDAYSTKGVTPEKISGRIKIQNIEFTYPTRPD 397
Query: 684 QPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHL 505
I+K + A GQT+ALVG SG GKST I +L+RFY+ G + ID I ++ +L
Sbjct: 398 VQILKDVSLEAQPGQTIALVGSSGCGKSTIIQLLQRFYNPDAGKIYIDDIAIEDFNIKYL 457
Query: 504 RTQMALVGQEPRLFAGTIRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGE 325
R + +V QEP LF +I +N+ G DV + IN+AL+ ANA F+ P G++T VG+
Sbjct: 458 RQLVGVVSQEPNLFNTSIEQNIRYGRADVDSDAINRALKEANALDFIKTFPEGLNTLVGD 517
Query: 324 KGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIA 145
+G Q+SGGQKQRIAIARALVR+PKILLLDEATSALD+ESE VQ ALD A GRT I IA
Sbjct: 518 RGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESVVQAALDNASRGRTTIVIA 577
Query: 144 HRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQDLA 7
HRLS+++N+D I+ + GKV E G H L+ QKG Y++L+ Q A
Sbjct: 578 HRLSTVRNADKIIVMKAGKVMEIGTHDTLIEQKGLYHELVHAQVFA 623
>gi|2506118|sp|P08183|MDR1_HUMAN Multidrug resistance protein 1
(P-glycoprotein 1) (CD243 antigen)
gi|1070659|pir||DVHU1 multidrug resistance protein 1 - human
gi|386862|gb|AAA59576.1| P glycoprotein
Length = 1280
Score = 819 bits (2116), Expect = 0.0
Identities = 479/1262 (37%), Positives = 699/1262 (54%), Gaps = 26/1262 (2%)
Frame = -1
Query: 3723 VSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKA 3544
VS+ +FRY D L + +GT+ AII G P++ LV G +T+ N
Sbjct: 34 VSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNIT 93
Query: 3543 NEN------------------VYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVY 3418
N + Y + GIG + + +IQ + R + ++R +F +
Sbjct: 94 NRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFH 153
Query: 3417 SVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWR 3238
+++RQ GWFD + G + T+L D + +I EGIGDK+G+ + A +V + W+
Sbjct: 154 AIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWK 213
Query: 3237 LASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEM 3058
L ++L ++P + ++ A+ ++S T KEL+ KAG++AEE L +RTV AF GQ++
Sbjct: 214 LTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKE 273
Query: 3057 VGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVF 2878
+ RY LE+ ++ + K YG L+ G + G V
Sbjct: 274 LERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSI-GQVL 332
Query: 2877 IVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRV 2698
V S+L+GA+ +G SP + NAR +A I++ ID P ID YSK+G + N+ G +
Sbjct: 333 TVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNL 392
Query: 2697 KFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVT 2518
+F NVHF YPSRK+ KIL GLNL V+ G +VALVG+SGCGKST+V L+ RLY+P G V+
Sbjct: 393 EFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVS 452
Query: 2517 IDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDF 2338
+DG D+R +N+ +LR +G+V QEP+LF TI N+ G T + + + K ANA+DF
Sbjct: 453 VDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDF 512
Query: 2337 IEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSA 2158
I K+P +DTL+G+ G QLSGGQKQR+AIAR L+R+PK+LLLDEATSALD +SE++VQ A
Sbjct: 513 IMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVA 572
Query: 2157 LNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFK 1978
L+ A KGRTTI+IAHRLST+R AD I F+ GVIVE GNH+EL++ G YF LV Q
Sbjct: 573 LDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAG 632
Query: 1977 ADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXX 1798
+ + ++D + R S S GS+
Sbjct: 633 NEVELENAADESKSEID--------ALEMSSNDSRSSLIRKRSTRRSVRGSQ-------- 676
Query: 1797 XXXXXXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWV 1618
++ + I K + Y +G A+I G PA A+IF +
Sbjct: 677 -AQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKI 735
Query: 1617 FEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRN 1438
FT + + + F ++G+ + + F E L+ R R FR+
Sbjct: 736 IGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRS 795
Query: 1437 LLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCW 1258
+L QD S+FD+P + G L TRLA+DA +K + +R+ + IY W
Sbjct: 796 MLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGW 855
Query: 1257 QXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQN----DDAGRIAIEIIENVKTIQLLTR 1090
Q + + I ++ +++ + +++ + AG+IA E IEN +T+ LT+
Sbjct: 856 Q---LTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTQ 912
Query: 1089 CELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSD 910
+ F Y S + R+ L+K I I +S TQ+ MYF + G ++ S +
Sbjct: 913 EQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFE 972
Query: 909 DTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDL-MEGDRPE-IR 736
D A++ GA+AV + + P++ KAK +A + II + P EG P +
Sbjct: 973 DVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLE 1032
Query: 735 GNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGG 556
GN+ F V F+YP RP P+++GL +GQT+ALVG SG GKST + +LERFYD G
Sbjct: 1033 GNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAG 1092
Query: 555 ALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG--LKDVPLEKINQALELA 382
+ +DG++I++L++ LR + +V QEP LF +I EN+ G + V E+I +A + A
Sbjct: 1093 KVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEA 1152
Query: 381 NANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESER 202
N + F+ +LP T VG+KG QLSGGQKQRIAIARALVR P ILLLDEATSALD+ESE+
Sbjct: 1153 NIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEK 1212
Query: 201 AVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIK 22
VQEALD+AREGRTCI IAHRLS+IQN+DLIV G+V+E G H QL+ QKG Y+ ++
Sbjct: 1213 VVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVS 1272
Query: 21 KQ 16
Q
Sbjct: 1273 VQ 1274
>gi|42741659|ref|NP_000918.2| ATP-binding cassette sub-family B member
1; multidrug resistance 1; P glycoprotein 1; doxorubicin
resistance; colchicin sensitivity [Homo sapiens]
Length = 1280
Score = 818 bits (2113), Expect = 0.0
Identities = 478/1262 (37%), Positives = 699/1262 (54%), Gaps = 26/1262 (2%)
Frame = -1
Query: 3723 VSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKA 3544
VS+ +FRY D L + +GT+ AII G P++ LV G +T+ N
Sbjct: 34 VSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNIT 93
Query: 3543 NEN------------------VYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVY 3418
N + Y + GIG + + +IQ + R + ++R +F +
Sbjct: 94 NRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFH 153
Query: 3417 SVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWR 3238
+++RQ GWFD + G + T+L D + +I EGIGDK+G+ + A +V + W+
Sbjct: 154 AIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWK 213
Query: 3237 LASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEM 3058
L ++L ++P + ++ A+ ++S T KEL+ KAG++AEE L +RTV AF GQ++
Sbjct: 214 LTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKE 273
Query: 3057 VGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVF 2878
+ RY LE+ ++ + K YG L+ G + G V
Sbjct: 274 LERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSI-GQVL 332
Query: 2877 IVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRV 2698
V S+L+GA+ +G SP + NAR +A I++ ID P ID YSK+G + N+ G +
Sbjct: 333 TVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNL 392
Query: 2697 KFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVT 2518
+F NVHF YPSRK+ KIL GLNL V+ G +VALVG+SGCGKST+V L+ RLY+P G V+
Sbjct: 393 EFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVS 452
Query: 2517 IDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDF 2338
+DG D+R +N+ +LR +G+V QEP+LF TI N+ G T + + + K ANA+DF
Sbjct: 453 VDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDF 512
Query: 2337 IEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSA 2158
I K+P +DTL+G+ G QLSGGQKQR+AIAR L+R+PK+LLLDEATSALD +SE++VQ A
Sbjct: 513 IMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVA 572
Query: 2157 LNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFK 1978
L+ A KGRTTI+IAHRLST+R AD I F+ GVIVE GNH+EL++ G YF LV Q
Sbjct: 573 LDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAG 632
Query: 1977 ADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXX 1798
+ + ++D + R S S GS+
Sbjct: 633 NEVELENAADESKSEID--------ALEMSSNDSRSSLIRKRSTRRSVRGSQ-------- 676
Query: 1797 XXXXXXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWV 1618
++ + I K + Y +G A+I G PA A+IF +
Sbjct: 677 -AQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKI 735
Query: 1617 FEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRN 1438
FT + + + F ++G+ + + F E L+ R R FR+
Sbjct: 736 IGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRS 795
Query: 1437 LLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCW 1258
+L QD S+FD+P + G L TRLA+DA +K + +R+ + IY W
Sbjct: 796 MLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGW 855
Query: 1257 QXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQN----DDAGRIAIEIIENVKTIQLLTR 1090
Q + + I ++ +++ + +++ + +G+IA E IEN +T+ LT+
Sbjct: 856 Q---LTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTQ 912
Query: 1089 CELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSD 910
+ F Y S + R+ L+K I I +S TQ+ MYF + G ++ S +
Sbjct: 913 EQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFE 972
Query: 909 DTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDL-MEGDRPE-IR 736
D A++ GA+AV + + P++ KAK +A + II + P EG P +
Sbjct: 973 DVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLE 1032
Query: 735 GNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGG 556
GN+ F V F+YP RP P+++GL +GQT+ALVG SG GKST + +LERFYD G
Sbjct: 1033 GNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAG 1092
Query: 555 ALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG--LKDVPLEKINQALELA 382
+ +DG++I++L++ LR + +V QEP LF +I EN+ G + V E+I +A + A
Sbjct: 1093 KVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEA 1152
Query: 381 NANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESER 202
N + F+ +LP T VG+KG QLSGGQKQRIAIARALVR P ILLLDEATSALD+ESE+
Sbjct: 1153 NIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEK 1212
Query: 201 AVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIK 22
VQEALD+AREGRTCI IAHRLS+IQN+DLIV G+V+E G H QL+ QKG Y+ ++
Sbjct: 1213 VVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVS 1272
Query: 21 KQ 16
Q
Sbjct: 1273 VQ 1274
>gi|8926217|gb|AAF81747.1| his-tagged-multidrug resistance
glycoprotein MDR1 [synthetic construct]
Length = 1287
Score = 817 bits (2111), Expect = 0.0
Identities = 489/1273 (38%), Positives = 711/1273 (55%), Gaps = 29/1273 (2%)
Frame = -1
Query: 3747 NQQLEAQP-VSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALL---- 3583
N++ E +P VS +FRY D L + +GT+ AII G + P++ LV G +T++
Sbjct: 31 NEKKEKKPTVSTFAMFRYSNWLDRLYMLVGTMAAIIHGAALPLMMLVFGNMTDSFANAGI 90
Query: 3582 ----VYPP--------TSKQFRNKANENV----YIFLGIGIFISITNFIQYMCFQHCCTR 3451
+P ++ F N E + Y + GIG + + +IQ + R
Sbjct: 91 SRNKTFPVIINESITNNTQHFINHLEEEMTTYAYYYSGIGAGVLVAAYIQVSFWCLAAGR 150
Query: 3450 VMAQMRHRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIA 3271
+ ++R +F ++++RQ GWFD + G + T+L D + +I EGIGDK+G+ + A
Sbjct: 151 QILKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSIATFFT 210
Query: 3270 AIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVR 3091
+V + W+L ++L ++P + ++ A+ ++S T KEL+ KAG++AEE L +R
Sbjct: 211 GFIVGFTRGWKLTLVILAISPVLGLSAAIWAKILSSFTDKELLAYAKAGAVAEEVLAAIR 270
Query: 3090 TVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLK 2911
TV AF GQ++ + RY LE+ ++ + K YG L+
Sbjct: 271 TVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTSLVL 330
Query: 2910 VGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKA 2731
+ G V V S+L+GA+ +G SP + NAR +A I++ ID P ID YSK+
Sbjct: 331 SSEYSI-GQVLTVFFSVLIGAFSIGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKS 389
Query: 2730 GKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLT 2551
G + N+ G ++F+NVHF YPSRK+ KIL GLNL V+ G +VALVG+SGCGKST+V L+
Sbjct: 390 GHKPDNIKGNLEFKNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQ 449
Query: 2550 RLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMI 2371
RLY+P G V IDG D+R +N+ LR G+V QEP+LF TI N+ G T + +
Sbjct: 450 RLYDPTDGMVCIDGQDIRTINVRHLREITGVVSQEPVLFATTIAENIRYGRENVTMDEIE 509
Query: 2370 EVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSAL 2191
+ K ANA+DFI K+P +DTL+G+ G QLSGGQKQR+AIAR L+R+PK+LLLDEATSAL
Sbjct: 510 KAVKEANAYDFIMKLPNKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSAL 569
Query: 2190 DAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGR 2011
D +SE++VQ AL+ A KGRTTI+IAHRLST+R AD I F+ GVIVE GNH+EL++ G
Sbjct: 570 DTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGI 629
Query: 2010 YFDLVKAQQFKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFS 1831
YF LV Q EI+L++ ++ G+SL S
Sbjct: 630 YFKLVTMQ-----------TRGNEIELENATGESKSESDALEMSPKDS---GSSLIKRRS 675
Query: 1830 GSKRSXXXXXXXXXXXXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLE 1651
++RS + + I K + Y +G A+I G
Sbjct: 676 -TRRS--IHAPQGQDRKLGTKEDLNENVPPVSFWRILKLNSTEWPYFVVGIFCAIINGGL 732
Query: 1650 LPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENL 1471
PA ++IF + FT M + F +G+ + + F E L
Sbjct: 733 QPAFSIIFSRIIGIFTRDEDPETKRQNSNMFSVLFLVLGIISFITFFLQGFTFGKAGEIL 792
Query: 1470 SMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXX 1291
+ R R FR++L QD S+FD+P + G L TRLA+DA +K + +R+ +
Sbjct: 793 TKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLG 852
Query: 1290 XXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQN----DDAGRIAIEII 1123
IY WQ + + I ++ +++ + +++ + AG+IA E I
Sbjct: 853 TGIIISLIYGWQ---LTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAI 909
Query: 1122 ENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGI 943
EN +T+ LTR + F Y S + R+ L+K I +++S+TQ+ MYF + G
Sbjct: 910 ENFRTVVSLTREQKFEYMYAQSLQVPYRNSLRKAHIFGVSFSITQAMMYFSYAGCFRFGA 969
Query: 942 RIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDL 763
++ + D A++ GA+AV + + P++ KAK +A + II + P
Sbjct: 970 YLVANEFMNFQDVLLVFSAIVFGAMAVGQVSSFAPDYAKAKVSAAHVIMIIEKSPLIDSY 1029
Query: 762 M-EGDRPE-IRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIG 589
G +P + GN+ F V F+YP RP P+++GL +GQT+ALVG SG GKST +
Sbjct: 1030 SPHGLKPNTLEGNVTFNEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQ 1089
Query: 588 MLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG--LKDVP 415
+LERFYD G++ IDG++I+ L++ LR + +V QEP LF +I EN+ G + V
Sbjct: 1090 LLERFYDPLAGSVLIDGKEIKHLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVS 1149
Query: 414 LEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDE 235
E+I QA + AN + F+ LP +T VG+KG QLSGGQKQRIAIARALVR P ILLLDE
Sbjct: 1150 HEEIMQAAKEANIHHFIETLPEKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDE 1209
Query: 234 ATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLM 55
ATSALD+ESE+ VQEALD+AREGRTCI IAHRLS+IQN+DLIV GKV+E G H QL+
Sbjct: 1210 ATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGKVKEHGTHQQLL 1269
Query: 54 HQKGRYYKLIKKQ 16
QKG Y+ +I Q
Sbjct: 1270 AQKGIYFSMISVQ 1282
>gi|283552|pir||S27338 P-glycoprotein C - Caenorhabditis elegans
gi|6811|emb|CAA46191.1| P-glycoprotein C [Caenorhabditis elegans]
Length = 1254
Score = 817 bits (2111), Expect = 0.0
Identities = 475/1252 (37%), Positives = 700/1252 (54%), Gaps = 21/1252 (1%)
Frame = -1
Query: 3708 LFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKANENV- 3532
+FR DY+L G I + ++G P +L+ + NAL+ Q++N
Sbjct: 34 VFRDADYKDYILFSGGLILSAVNGALVPFNSLIFEGIANALM---EGESQYQNGTINMPW 90
Query: 3531 -----------YIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFD 3385
Y +LG+ +F+ ++ C C R + +R +++ SVLRQ+A WFD
Sbjct: 91 FSSEIKMFCLRYFYLGVALFLC--SYFANSCLYTLCERRLHCIRKKYLKSVLRQDAKWFD 148
Query: 3384 KNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPT 3205
+ G +T K++ +E+I++GIGDK+GVL+ G A I+ + + + W+L +M+ P
Sbjct: 149 ETTIGGLTQKMSSGIEKIKDGIGDKVGVLVGGVATFISGVSIGFYMCWQLTLVMMITVPL 208
Query: 3204 CCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKG 3025
M L A+ + T E+ AG +A E + G+RTV AFN Q + RY +L +
Sbjct: 209 QLGSMYLSAKHLNRATKNEMSAYSNAGGMANEVIAGIRTVMAFNAQPFEINRYAHQLNEA 268
Query: 3024 RKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAY 2845
R+ + K YGA L G +++ G VF V ++L+G
Sbjct: 269 RRMGIRKAIILAICTAFPLMLMFTCMAVAFWYGATLAAAGAVSS-GAVFAVFWAVLIGTR 327
Query: 2844 FLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPS 2665
LG +PH+ + AR++ I++ ID P+I S GK + + G++ F+ + F YP+
Sbjct: 328 RLGEAAPHLGAITGARLAIHDIFKVIDHEPEIKCTSSEGKIPEKIQGKLTFDGIEFTYPT 387
Query: 2664 RKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNI 2485
R + KIL G++ V PG +VALVGHSGCGKSTS+GLL R Y AG + +DG ++E NI
Sbjct: 388 RPELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNI 447
Query: 2484 EWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYDTL 2305
WLR+T+GIVQQEPI+F T+ N+ +G+ T + + E CKMANAH+FI K+ YDT+
Sbjct: 448 RWLRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTV 507
Query: 2304 IGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTI 2125
IG G VQLSGGQKQRVAIAR ++R P++LLLDEATSALD +SE +VQ+AL+ AS+GRTT+
Sbjct: 508 IGAGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTL 567
Query: 2124 MIAHRLSTIREADKIVFFEKGVIVEAGNHEELV-RLGGRYFDLVKAQQFKADPXXXXXXX 1948
IAHRLSTIR A H+EL+ + G Y +VKAQ+ +
Sbjct: 568 CIAHRLSTIRNAS--------------THDELISKDDGIYASMVKAQEIERAKEDTTLD- 612
Query: 1947 XXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXXXXXXXXXXXX 1768
D +D ++ + + +
Sbjct: 613 ----DEEDEKTHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPEWEIENARE 668
Query: 1767 XXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYG 1588
E+G + A DIFK A + + VF LIRG PA ++++G +F+ + G
Sbjct: 669 EMIEEGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFK---ILSAG 725
Query: 1587 G------RMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQ 1426
G +++ + ++AF S L S L E +S R R+ FRN++ Q
Sbjct: 726 GDDVSIKALLNSLWFILLAFTG-----GISTLISGSLLGKAGETMSGRLRMDVFRNIMQQ 780
Query: 1425 DASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXX 1246
DASYFD+ H G L +RLA+DAPN++A +D R+ +V Y W
Sbjct: 781 DASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAP 840
Query: 1245 XXXXXXXXLAFVMIGLAYKISLMNVEQIQND-DAGRIAIEIIENVKTIQLLTRCELFFDH 1069
L V +A + + + +A R+ E I N KT+Q LT+ E +D
Sbjct: 841 IGLATELLLVVVQSSVAQYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDA 900
Query: 1068 YQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGII 889
+ +SK R + +G+ ++++++L SF+ + Y G+ +I + F+ I
Sbjct: 901 FTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIE 960
Query: 888 AMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDL-MEGDRPEIRGNILFENV 712
A+ + +++VM +A YFPE+V+A+ +AG++F +I +K + + GD P I+GNI V
Sbjct: 961 ALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGV 1020
Query: 711 KFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQD 532
F+YP R Q ++ G +A GQTVALVGPSG GKST I ++ER+YD G+++ID D
Sbjct: 1021 YFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSD 1080
Query: 531 IRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGLKDVPLEKINQALELANANRFLANLP 352
IR LS+ HLR +ALVGQEP LF TIREN+ GL+++ +++ +A LAN + F+ LP
Sbjct: 1081 IRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLP 1140
Query: 351 AGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAR 172
G DT VG GG+LSGGQKQR+AIARA+VRDPKILLLDEATSALD+ESE+ VQEALD+AR
Sbjct: 1141 DGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKAR 1200
Query: 171 EGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQ 16
GRTC+ IAHRLS+IQN+D I+ GK E G H L+ ++G YY+L++KQ
Sbjct: 1201 LGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 1252
Score = 301 bits (772), Expect = 6e-80
Identities = 184/584 (31%), Positives = 304/584 (51%), Gaps = 2/584 (0%)
Frame = -1
Query: 3732 AQPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFR 3553
A S+ +F+Y + + I + +I G + P ++V G++ L
Sbjct: 675 AMEASLFDIFKYASP-EMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSA---GGDDVS 730
Query: 3552 NKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFD--KN 3379
KA N F+ + I+ I + ++R ++++Q+A +FD ++
Sbjct: 731 IKALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRH 790
Query: 3378 HSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCC 3199
+ G++T++L ++ I +L +L G L + VA+ Y W +A + L
Sbjct: 791 NVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGLATELLLV 850
Query: 3198 ICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRK 3019
+ S +A+ + +++ +A + ES+ +TVQA QE M + A + +
Sbjct: 851 VVQSSVAQYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHR 910
Query: 3018 FAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFL 2839
A+ + ++G +L+ +TP VF V+ ++ + + +
Sbjct: 911 RAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNW-STPYTVFQVIEALNMASMSV 969
Query: 2838 GLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRK 2659
L + + + AR+SA ++ I + ID G + G + V+F YP+R+
Sbjct: 970 MLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDT-PTIKGNINMRGVYFAYPNRR 1028
Query: 2658 DAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEW 2479
+L+G N+ G +VALVG SGCGKST++ L+ R Y+ G+V ID +D+R+L+++
Sbjct: 1029 RQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKH 1088
Query: 2478 LRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYDTLIG 2299
LR+ + +V QEP LFN TI N+ G T++ + + +AN H F+ +P GYDT +G
Sbjct: 1089 LRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYDTSVG 1148
Query: 2298 DGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMI 2119
G +LSGGQKQRVAIAR ++RDPK+LLLDEATSALD +SE IVQ AL+ A GRT ++I
Sbjct: 1149 ASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVI 1208
Query: 2118 AHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQ 1987
AHRLSTI+ ADKI+ G +E G H+ L+ G Y+ LV+ Q
Sbjct: 1209 AHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 1252
Score = 256 bits (654), Expect = 3e-66
Identities = 183/589 (31%), Positives = 297/589 (50%), Gaps = 14/589 (2%)
Frame = -1
Query: 1734 YLDIFKNAK-GNYLYMFLGTVFALIRGLELPALALIFGWV----FEGFTFVPYGGRMM-- 1576
+ D+F++A +Y+ G + + + G +P +LIF + EG + G M
Sbjct: 31 FFDVFRDADYKDYILFSGGLILSAVNGALVPFNSLIFEGIANALMEGESQYQNGTINMPW 90
Query: 1575 --HRMAMAVIAFASVGVGVWF-SQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDN 1405
+ M + + +GV ++ S A+S L+ + L R + +++L QDA +FD
Sbjct: 91 FSSEIKMFCLRYFYLGVALFLCSYFANSCLYTLCERRLHC-IRKKYLKSVLRQDAKWFDE 149
Query: 1404 PAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXX 1225
G L +++S IK + ++ + CWQ
Sbjct: 150 TTI--GGLTQKMSSGIEKIKDGIGDKVGVLVGGVATFISGVSIGFYMCWQLTLVMMITVP 207
Query: 1224 XLAFVMIGLAYKISLMNVEQIQN-DDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQ 1048
M A ++ ++ +AG +A E+I ++T+ + Y +
Sbjct: 208 LQLGSMYLSAKHLNRATKNEMSAYSNAGGMANEVIAGIRTVMAFNAQPFEINRYAHQLNE 267
Query: 1047 QKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAV 868
+R ++K +I AI + M+ M + G + G SS F A+++G
Sbjct: 268 ARRMGIRKAIILAICTAFPLMLMFTCMAVAFWYGATLAAAGAVSSGAVFAVFWAVLIGTR 327
Query: 867 AVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTG-DLMEGDRPE-IRGNILFENVKFSYPQ 694
+ +A + A+ A +F +I +P EG PE I+G + F+ ++F+YP
Sbjct: 328 RLGEAAPHLGAITGARLAIHDIFKVIDHEPEIKCTSSEGKIPEKIQGKLTFDGIEFTYPT 387
Query: 693 RPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSL 514
RP I+KG+ + G+TVALVG SG GKST+IG+L RFY+ G +++DG I++ ++
Sbjct: 388 RPELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNI 447
Query: 513 FHLRTQMALVGQEPRLFAGTIRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTD 334
LR+ + +V QEP +F T+ EN+ +G + + I +A ++ANA+ F+ L DT
Sbjct: 448 RWLRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTV 507
Query: 333 VGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCI 154
+G QLSGGQKQR+AIARA+VR P+ILLLDEATSALD+ESER VQ ALD+A EGRT +
Sbjct: 508 IGAGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTL 567
Query: 153 TIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQ-KGRYYKLIKKQDL 10
IAHRLS+I+N A H +L+ + G Y ++K Q++
Sbjct: 568 CIAHRLSTIRN--------------ASTHDELISKDDGIYASMVKAQEI 602
>gi|46394986|gb|AAS91649.1| multidrug resistance protein 1a;
P-glycoprotein [Rattus norvegicus]
Length = 1272
Score = 817 bits (2110), Expect = 0.0
Identities = 481/1274 (37%), Positives = 718/1274 (55%), Gaps = 31/1274 (2%)
Frame = -1
Query: 3744 QQLEAQP-VSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNA------- 3589
++ E +P VS+ +FRY D + +GT+ AII G++ P++ LV G +T++
Sbjct: 25 EKKEKKPAVSVLTMFRYAGWLDRFYMLLGTLAAIIHGIALPLMMLVFGDMTDSFANVGNN 84
Query: 3588 --LLVYPPTS--KQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFV 3421
+ Y T + +++ Y + GIG + I +IQ + R + ++R +F
Sbjct: 85 RSMSFYNATDIYAKLKDEMTTYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFF 144
Query: 3420 YSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEW 3241
++++ Q GWFD + G + T+L D + +I EGIGDK+G+ + A ++ + W
Sbjct: 145 HAIMNQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGW 204
Query: 3240 RLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEE 3061
+L ++L ++P + + A+ ++S T KEL KAG++AEE L +RTV AF GQ++
Sbjct: 205 KLTLVILAISPVLGLSAGIWAKILSSFTDKELQAYAKAGAVAEEVLAAIRTVIAFGGQKK 264
Query: 3060 MVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDV 2881
+ RY LE+ ++ + K YG L+ + T G V
Sbjct: 265 ELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLV-ISKEYTIGQV 323
Query: 2880 FIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGR 2701
V S+L+GA+ +G SP++ NAR +A ++ ID P ID +SK+G + N+ G
Sbjct: 324 LTVFFSVLIGAFSVGQASPNIEAFANARGAAYEVFSIIDNKPSIDSFSKSGHKPDNIQGN 383
Query: 2700 VKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNV 2521
++F+N+HF YPSRKD +IL GLNL V+ G +VALVG+SGCGKST+V LL RLY+P G V
Sbjct: 384 LEFKNIHFSYPSRKDVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEGEV 443
Query: 2520 TIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHD 2341
+IDG D+R +N+ +LR +G+V QEP+LF TI N+ G T + + + K ANA+D
Sbjct: 444 SIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYD 503
Query: 2340 FIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQS 2161
FI K+P +DTL+G+ G QLSGGQKQR+AIAR L+R+PK+LLLDEATSALD +SE++VQ+
Sbjct: 504 FIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQA 563
Query: 2160 ALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQF 1981
AL+ A +GRTTI+IAHRLST+R AD I F+ GVIVE GNH+EL+R G YF LV Q
Sbjct: 564 ALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQ-- 621
Query: 1980 KADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXX 1801
EI+L + EA + +++ SK S
Sbjct: 622 ---------TAGNEIELGN-----------------EACESKDGIDNVDMSSKDSGSSLI 655
Query: 1800 XXXXXXXXXXXXXXEDGQIT-----------AGYLDIFKNAKGNYLYMFLGTVFALIRGL 1654
+DG+++ A + I K + Y +G A+I G
Sbjct: 656 RRRSTRKSIRGPHDQDGELSTKEALDDDVPPASFWRILKLNSTEWPYFVVGVFCAIINGG 715
Query: 1653 ELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSEN 1474
PA ++IF V FT + + F +G+ + + F E
Sbjct: 716 LQPAFSIIFSKVVGVFTKNDTPEIQRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEI 775
Query: 1473 LSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXX 1294
L+ R R F+++L QD S+FD+P + G L TRLA+DA +K +R+ +
Sbjct: 776 LTKRLRYMVFKSMLRQDISWFDDPKNTTGALTTRLANDAAQVKGATGSRLAVITQNIANL 835
Query: 1293 XXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQN----DDAGRIAIEI 1126
IY WQ + + I ++ +++ + +++ + +G+IA E
Sbjct: 836 GTGIIISLIYGWQ---LTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEA 892
Query: 1125 IENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVG 946
IEN +T+ LTR + F Y S + R+ LKK + I +S TQ+ MYF + G
Sbjct: 893 IENFRTVVSLTREQKFETMYAQSLQIPYRNALKKAHVFGITFSFTQAMMYFSYAACFRFG 952
Query: 945 IRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGD 766
++ + + ++ A++ GA+AV + + P++ KAK +A + II + P
Sbjct: 953 AYLVARELMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKAKVSASHIIRIIEKIPEIDS 1012
Query: 765 L-MEGDRPE-IRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNI 592
EG +P + GN+ F V F+YP RP P+++GL +GQT+ALVG SG GKST +
Sbjct: 1013 YSTEGLKPNMLEGNVKFNGVMFNYPTRPNIPVLQGLSLEGKKGQTLALVGSSGCGKSTVV 1072
Query: 591 GMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG--LKDV 418
+LERFYD G + +DG++I++L++ LR + +V QEP LF +I EN+ G + V
Sbjct: 1073 QLLERFYDPMAGTVFLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVV 1132
Query: 417 PLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLD 238
E+I +A + AN ++F+ +LP +T VG+KG QLSGGQKQRIAIARALVR P ILLLD
Sbjct: 1133 SHEEIVKAAKEANIHQFIDSLPEKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLD 1192
Query: 237 EATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQL 58
EATSALD+ESE+ VQEALD+AREGRTCI IAHRLS+IQN+DLIV I G+V+E G H QL
Sbjct: 1193 EATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGQVKEHGTHQQL 1252
Query: 57 MHQKGRYYKLIKKQ 16
+ QKG Y+ ++ Q
Sbjct: 1253 LAQKGIYFSMVSVQ 1266
>gi|46394982|gb|AAS91647.1| multidrug resistance protein 1;
P-glycoprotein [Canis familiaris]
Length = 1281
Score = 816 bits (2109), Expect = 0.0
Identities = 488/1273 (38%), Positives = 711/1273 (55%), Gaps = 29/1273 (2%)
Frame = -1
Query: 3747 NQQLEAQP-VSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALL---- 3583
N++ E +P VS +FRY D L + +GT+ AII G + P++ LV G +T++
Sbjct: 25 NEKKEKKPTVSTFAMFRYSNWLDRLYMLVGTMAAIIHGAALPLMMLVFGNMTDSFANAGI 84
Query: 3582 ----VYPP--------TSKQFRNKANENV----YIFLGIGIFISITNFIQYMCFQHCCTR 3451
+P ++ F N E + Y + GIG + + +IQ + R
Sbjct: 85 SRNKTFPVIINESITNNTQHFINHLEEEMTTYAYYYSGIGAGVLVAAYIQVSFWCLAAGR 144
Query: 3450 VMAQMRHRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIA 3271
+ ++R +F ++++RQ GWFD + G + T+L D + +I EGIGDK+G+ + A
Sbjct: 145 QILKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSIATFFT 204
Query: 3270 AIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVR 3091
+V + W+L ++L ++P + ++ A+ ++S T KEL+ KAG++AEE L +R
Sbjct: 205 GFIVGFTRGWKLTLVILAISPVLGLSAAIWAKILSSFTDKELLAYAKAGAVAEEVLAAIR 264
Query: 3090 TVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLK 2911
TV AF GQ++ + RY LE+ ++ + K YG L+
Sbjct: 265 TVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTSLVL 324
Query: 2910 VGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKA 2731
+ G V V S+L+GA+ +G SP + NAR +A I++ ID P ID YSK+
Sbjct: 325 SSEYSI-GQVLTVFFSVLIGAFSIGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKS 383
Query: 2730 GKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLT 2551
G + N+ G ++F+NVHF YPSRK+ KIL GLNL V+ G +VALVG+SGCGKST+V L+
Sbjct: 384 GHKPDNIKGNLEFKNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQ 443
Query: 2550 RLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMI 2371
RLY+P G V IDG D+R +N+ LR G+V QEP+LF TI N+ G T + +
Sbjct: 444 RLYDPTDGMVCIDGQDIRTINVRHLREITGVVSQEPVLFATTIAENIRYGRENVTMDEIE 503
Query: 2370 EVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSAL 2191
+ K ANA+DFI K+P +DTL+G+ G QLSGGQKQR+AIAR L+R+PK+LLLDEATSAL
Sbjct: 504 KAVKEANAYDFIMKLPNKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSAL 563
Query: 2190 DAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGR 2011
D +SE++VQ AL+ A KGRTTI+IAHRLST+R AD I F+ GVIVE GNH+EL++ G
Sbjct: 564 DTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGI 623
Query: 2010 YFDLVKAQQFKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFS 1831
YF LV Q EI+L++ ++ G+SL S
Sbjct: 624 YFKLVTMQ-----------TRGNEIELENATGESKSESDALEMSPKDS---GSSLIKRRS 669
Query: 1830 GSKRSXXXXXXXXXXXXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLE 1651
++RS + + I K + Y +G A+I G
Sbjct: 670 -TRRS--IHAPQGQDRKLGTKEDLNENVPPVSFWRILKLNSTEWPYFVVGIFCAIINGGL 726
Query: 1650 LPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENL 1471
PA ++IF + FT M + F +G+ + + F E L
Sbjct: 727 QPAFSIIFSRIIGIFTRDEDPETKRQNSNMFSVLFLVLGIISFITFFLQGFTFGKAGEIL 786
Query: 1470 SMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXX 1291
+ R R FR++L QD S+FD+P + G L TRLA+DA +K + +R+ +
Sbjct: 787 TKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLG 846
Query: 1290 XXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQN----DDAGRIAIEII 1123
IY WQ + + I ++ +++ + +++ + AG+IA E I
Sbjct: 847 TGIIISLIYGWQ---LTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAI 903
Query: 1122 ENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGI 943
EN +T+ LTR + F Y S + R+ L+K I +++S+TQ+ MYF + G
Sbjct: 904 ENFRTVVSLTREQKFEYMYAQSLQVPYRNSLRKAHIFGVSFSITQAMMYFSYAGCFRFGA 963
Query: 942 RIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDL 763
++ + D A++ GA+AV + + P++ KAK +A + II + P
Sbjct: 964 YLVANEFMNFQDVLLVFSAIVFGAMAVGQVSSFAPDYAKAKVSAAHVIMIIEKSPLIDSY 1023
Query: 762 M-EGDRPE-IRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIG 589
G +P + GN+ F V F+YP RP P+++GL +GQT+ALVG SG GKST +
Sbjct: 1024 SPHGLKPNTLEGNVTFNEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQ 1083
Query: 588 MLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG--LKDVP 415
+LERFYD G++ IDG++I+ L++ LR + +V QEP LF +I EN+ G + V
Sbjct: 1084 LLERFYDPLAGSVLIDGKEIKHLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVS 1143
Query: 414 LEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDE 235
E+I QA + AN + F+ LP +T VG+KG QLSGGQKQRIAIARALVR P ILLLDE
Sbjct: 1144 HEEIVQAAKEANIHHFIETLPEKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDE 1203
Query: 234 ATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLM 55
ATSALD+ESE+ VQEALD+AREGRTCI IAHRLS+IQN+DLIV GKV+E G H QL+
Sbjct: 1204 ATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGKVKEHGTHQQLL 1263
Query: 54 HQKGRYYKLIKKQ 16
QKG Y+ ++ Q
Sbjct: 1264 AQKGIYFSMVSVQ 1276
>gi|25453402|ref|NP_596892.1| ATP-binding cassette, sub-family B
(MDR/TAP), member 1A; multiple drug resistant 1a [Rattus
norvegicus]
gi|34853968|ref|XP_346684.1| hypothetical protein XP_346683 [Rattus
norvegicus]
gi|7739773|gb|AAF69007.1| multidrug resistance protein 1a [Rattus
norvegicus]
Length = 1272
Score = 816 bits (2108), Expect = 0.0
Identities = 481/1274 (37%), Positives = 717/1274 (55%), Gaps = 31/1274 (2%)
Frame = -1
Query: 3744 QQLEAQP-VSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNA------- 3589
++ E +P VS+ +FRY D + +GT+ AII G++ P++ LV G +T++
Sbjct: 25 EKKEKKPAVSVLTMFRYAGWLDRFYMLLGTLAAIIHGIALPLMMLVFGDMTDSFANVGNN 84
Query: 3588 --LLVYPPTS--KQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFV 3421
+ Y T + ++ Y + GIG + I +IQ + R + ++R +F
Sbjct: 85 RSMSFYNATDIYAKLEDEMTTYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFF 144
Query: 3420 YSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEW 3241
++++ Q GWFD + G + T+L D + +I EGIGDK+G+ + A ++ + W
Sbjct: 145 HAIMNQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGW 204
Query: 3240 RLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEE 3061
+L ++L ++P + + A+ ++S T KEL KAG++AEE L +RTV AF GQ++
Sbjct: 205 KLTLVILAISPVLGLSAGIWAKILSSFTDKELQAYAKAGAVAEEVLAAIRTVIAFGGQKK 264
Query: 3060 MVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDV 2881
+ RY LE+ ++ + K YG L+ + T G V
Sbjct: 265 ELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLV-ISKEYTIGQV 323
Query: 2880 FIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGR 2701
V S+L+GA+ +G SP++ NAR +A ++ ID P ID +SK+G + N+ G
Sbjct: 324 LTVFFSVLIGAFSVGQASPNIEAFANARGAAYEVFSIIDNKPSIDSFSKSGHKPDNIQGN 383
Query: 2700 VKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNV 2521
++F+N+HF YPSRKD +IL GLNL V+ G +VALVG+SGCGKST+V LL RLY+P G V
Sbjct: 384 LEFKNIHFSYPSRKDVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEGEV 443
Query: 2520 TIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHD 2341
+IDG D+R +N+ +LR +G+V QEP+LF TI N+ G T + + + K ANA+D
Sbjct: 444 SIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYD 503
Query: 2340 FIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQS 2161
FI K+P +DTL+G+ G QLSGGQKQR+AIAR L+R+PK+LLLDEATSALD +SE++VQ+
Sbjct: 504 FIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQA 563
Query: 2160 ALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQF 1981
AL+ A +GRTTI+IAHRLST+R AD I F+ GVIVE GNH+EL+R G YF LV Q
Sbjct: 564 ALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQ-- 621
Query: 1980 KADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXX 1801
EI+L + EA + +++ SK S
Sbjct: 622 ---------TAGNEIELGN-----------------EACESKDGIDNVDMSSKDSGSSLI 655
Query: 1800 XXXXXXXXXXXXXXEDGQIT-----------AGYLDIFKNAKGNYLYMFLGTVFALIRGL 1654
+DG+++ A + I K + Y +G A+I G
Sbjct: 656 RRRSTRKSIRGPHDQDGELSTKEALDDDVPPASFWRILKLNSTEWPYFVVGVFCAIINGG 715
Query: 1653 ELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSEN 1474
PA ++IF V FT + + F +G+ + + F E
Sbjct: 716 LQPAFSIIFSKVVGVFTKNDTPEIQRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEI 775
Query: 1473 LSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXX 1294
L+ R R F+++L QD S+FD+P + G L TRLA+DA +K +R+ +
Sbjct: 776 LTKRLRYMVFKSMLRQDISWFDDPKNTTGALTTRLANDAAQVKGATGSRLAVITQNIANL 835
Query: 1293 XXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQN----DDAGRIAIEI 1126
IY WQ + + I ++ +++ + +++ + +G+IA E
Sbjct: 836 GTGIIISLIYGWQ---LTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEA 892
Query: 1125 IENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVG 946
IEN +T+ LTR + F Y S + R+ LKK + I +S TQ+ MYF + G
Sbjct: 893 IENFRTVVSLTREQKFETMYAQSLQIPYRNALKKAHVFGITFSFTQAMMYFSYAACFRFG 952
Query: 945 IRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGD 766
++ + + ++ A++ GA+AV + + P++ KAK +A + II + P
Sbjct: 953 AYLVARELMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKAKVSASHIIRIIEKIPEIDS 1012
Query: 765 L-MEGDRPE-IRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNI 592
EG +P + GN+ F V F+YP RP P+++GL +GQT+ALVG SG GKST +
Sbjct: 1013 YSTEGLKPNMLEGNVKFNGVMFNYPTRPNIPVLQGLSLEVKKGQTLALVGSSGCGKSTVV 1072
Query: 591 GMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG--LKDV 418
+LERFYD G + +DG++I++L++ LR + +V QEP LF +I EN+ G + V
Sbjct: 1073 QLLERFYDPMAGTVFLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVV 1132
Query: 417 PLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLD 238
E+I +A + AN ++F+ +LP +T VG+KG QLSGGQKQRIAIARALVR P ILLLD
Sbjct: 1133 SHEEIVKAAKEANIHQFIDSLPEKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLD 1192
Query: 237 EATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQL 58
EATSALD+ESE+ VQEALD+AREGRTCI IAHRLS+IQN+DLIV I G+V+E G H QL
Sbjct: 1193 EATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGQVKEHGTHQQL 1252
Query: 57 MHQKGRYYKLIKKQ 16
+ QKG Y+ ++ Q
Sbjct: 1253 LAQKGIYFSMVSVQ 1266
>gi|2353264|gb|AAB69423.1| P-glycoprotein [Homo sapiens]
Length = 1279
Score = 816 bits (2108), Expect = 0.0
Identities = 479/1262 (37%), Positives = 700/1262 (54%), Gaps = 26/1262 (2%)
Frame = -1
Query: 3723 VSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKA 3544
VS+ +FRY D L + +GT+ AII G P++ LV G +T+ N
Sbjct: 34 VSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNIT 93
Query: 3543 NEN------------------VYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVY 3418
N + Y + GIG + + +IQ + R + ++R +F +
Sbjct: 94 NRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFH 153
Query: 3417 SVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWR 3238
+++RQ GWFD + G + T+L D + +I EGIGDK+G+ + A +V + W+
Sbjct: 154 AIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWK 213
Query: 3237 LASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEM 3058
L ++L ++P + ++ A+ ++S T KEL+ KAG++AEE L +RTV AF GQ++
Sbjct: 214 LTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKE 273
Query: 3057 VGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVF 2878
+ RY LE+ ++ + K YG L+ G + G V
Sbjct: 274 LERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSI-GQV- 331
Query: 2877 IVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRV 2698
+ V S+L+GA+ +G SP + NAR +A I++ ID P ID YSK+G + N+ G +
Sbjct: 332 LTVFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNL 391
Query: 2697 KFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVT 2518
+F NVHF YPSRK+ KIL GLNL V+ G +VALVG+SGCGKST+V L+ RLY+P G V+
Sbjct: 392 EFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVS 451
Query: 2517 IDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDF 2338
+DG D+R +N+ +LR +G+V QEP+LF TI N+ G T + + + K ANA+DF
Sbjct: 452 VDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDF 511
Query: 2337 IEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSA 2158
I K+P +DTL+G+ G QLSGGQKQR+AIAR L+R+PK+LLLDEATSALD +SE++VQ A
Sbjct: 512 IMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVA 571
Query: 2157 LNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFK 1978
L+ A KGRTTI+IAHRLST+R AD I F+ GVIVE GNH+EL++ G YF LV Q
Sbjct: 572 LDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAG 631
Query: 1977 ADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXX 1798
+ + ++D + R S S GS+
Sbjct: 632 NEVELENAADESKSEID--------ALEMSSNDSRSSLIRKRSTRRSVRGSQ-------- 675
Query: 1797 XXXXXXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWV 1618
++ + I K + Y +G A+I G PA A+IF +
Sbjct: 676 -AQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKI 734
Query: 1617 FEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRN 1438
FT + + + F ++G+ + + F E L+ R R FR+
Sbjct: 735 IGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRS 794
Query: 1437 LLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCW 1258
+L QD S+FD+P + G L TRLA+DA +K + +R+ + IY W
Sbjct: 795 MLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGW 854
Query: 1257 QXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQN----DDAGRIAIEIIENVKTIQLLTR 1090
Q + + I ++ +++ + +++ + AG+IA E IEN +T+ LT+
Sbjct: 855 Q---LTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTQ 911
Query: 1089 CELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSD 910
+ F Y S + R+ L+K I I +S TQ+ MYF + G ++ S +
Sbjct: 912 EQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFE 971
Query: 909 DTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDL-MEGDRPE-IR 736
D A++ GA+AV + + P++ KAK +A + II + P EG P +
Sbjct: 972 DVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLE 1031
Query: 735 GNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGG 556
GN+ F V F+YP RP P+++GL +GQT+ALVG SG GKST + +LERFYD G
Sbjct: 1032 GNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAG 1091
Query: 555 ALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG--LKDVPLEKINQALELA 382
+ +DG++I++L++ LR + +V QEP LF +I EN+ G + V E+I +A + A
Sbjct: 1092 KVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEA 1151
Query: 381 NANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESER 202
N + F+ +LP T VG+KG QLSGGQKQRIAIARALVR P ILLLDEATSALD+ESE+
Sbjct: 1152 NIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEK 1211
Query: 201 AVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIK 22
VQEALD+AREGRTCI IAHRLS+IQN+DLIV G+V+E G H QL+ QKG Y+ ++
Sbjct: 1212 VVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVS 1271
Query: 21 KQ 16
Q
Sbjct: 1272 VQ 1273
>gi|307180|gb|AAA59575.1| P-glycoprotein [Homo sapiens]
Length = 1280
Score = 816 bits (2107), Expect = 0.0
Identities = 478/1262 (37%), Positives = 698/1262 (54%), Gaps = 26/1262 (2%)
Frame = -1
Query: 3723 VSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKA 3544
VS+ +FRY D L + +GT+ AII G P++ LV G +T+ N
Sbjct: 34 VSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNIT 93
Query: 3543 NEN------------------VYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVY 3418
N + Y + GIG + + +IQ + R + ++R +F +
Sbjct: 94 NRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFH 153
Query: 3417 SVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWR 3238
+++RQ GWFD + G + T+L D + +I E IGDK+G+ + A +V + W+
Sbjct: 154 AIMRQEIGWFDVHDVGELNTRLTDDVSKINEVIGDKIGMFFQSMATFFTGFIVGFTRGWK 213
Query: 3237 LASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEM 3058
L ++L ++P + ++ A+ ++S T KEL+ KAG++AEE L +RTV AF GQ++
Sbjct: 214 LTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKE 273
Query: 3057 VGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVF 2878
+ RY LE+ ++ + K YG L+ G + G V
Sbjct: 274 LERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSI-GQVL 332
Query: 2877 IVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRV 2698
V S+L+GA+ +G SP + NAR +A I++ ID P ID YSK+G + N+ G +
Sbjct: 333 TVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNL 392
Query: 2697 KFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVT 2518
+F NVHF YPSRK+ KIL GLNL V+ G +VALVG+SGCGKST+V L+ RLY+P G V+
Sbjct: 393 EFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVS 452
Query: 2517 IDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDF 2338
+DG D+R +N+ +LR +G+V QEP+LF TI N+ G T + + + K ANA+DF
Sbjct: 453 VDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDF 512
Query: 2337 IEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSA 2158
I K+P +DTL+G+ G QLSGGQKQR+AIAR L+R+PK+LLLDEATSALD +SE++VQ A
Sbjct: 513 IMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVA 572
Query: 2157 LNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFK 1978
L+ A KGRTTI+IAHRLST+R AD I F+ GVIVE GNH+EL++ G YF LV Q
Sbjct: 573 LDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAG 632
Query: 1977 ADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXX 1798
+ + ++D + R S S GS+
Sbjct: 633 NEVELENAADESKSEID--------ALEMSSNDSRSSLIRKRSTRRSVRGSQ-------- 676
Query: 1797 XXXXXXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWV 1618
++ + I K + Y +G A+I G PA A+IF +
Sbjct: 677 -AQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKI 735
Query: 1617 FEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRN 1438
FT + + + F ++G+ + + F E L+ R R FR+
Sbjct: 736 IGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRS 795
Query: 1437 LLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCW 1258
+L QD S+FD+P + G L TRLA+DA +K + +R+ + IY W
Sbjct: 796 MLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGW 855
Query: 1257 QXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQN----DDAGRIAIEIIENVKTIQLLTR 1090
Q + + I ++ +++ + +++ + AG+IA E IEN +T+ LT+
Sbjct: 856 Q---LTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTQ 912
Query: 1089 CELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSD 910
+ F Y S + R+ L+K I I +S TQ+ MYF + G ++ S +
Sbjct: 913 EQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFE 972
Query: 909 DTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDL-MEGDRPE-IR 736
D A++ GA+AV + + P++ KAK +A + II + P EG P +
Sbjct: 973 DVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLE 1032
Query: 735 GNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGG 556
GN+ F V F+YP RP P+++GL +GQT+ALVG SG GKST + +LERFYD G
Sbjct: 1033 GNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAG 1092
Query: 555 ALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG--LKDVPLEKINQALELA 382
+ +DG++I++L++ LR + +V QEP LF +I EN+ G + V E+I +A + A
Sbjct: 1093 KVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEA 1152
Query: 381 NANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESER 202
N + F+ +LP T VG+KG QLSGGQKQRIAIARALVR P ILLLDEATSALD+ESE+
Sbjct: 1153 NIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEK 1212
Query: 201 AVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIK 22
VQEALD+AREGRTCI IAHRLS+IQN+DLIV G+V+E G H QL+ QKG Y+ ++
Sbjct: 1213 VVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVS 1272
Query: 21 KQ 16
Q
Sbjct: 1273 VQ 1274
>gi|126924|sp|P21448|MDR1_CRIGR Multidrug resistance protein 1
(P-glycoprotein 1)
gi|191165|gb|AAA68883.1| p-glycoprotein isoform I
Length = 1276
Score = 815 bits (2105), Expect = 0.0
Identities = 482/1279 (37%), Positives = 711/1279 (54%), Gaps = 36/1279 (2%)
Frame = -1
Query: 3744 QQLEAQPV-SIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPT 3568
++ E +PV S+ +FRY D L + +GT+ AII GV+ P++ LV G +T++
Sbjct: 25 EKKEKKPVVSVFTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLVFGDMTDSFASVGNI 84
Query: 3567 SKQFRNKANE----------------NVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQM 3436
N A + Y + GIG + I +IQ + R + ++
Sbjct: 85 PTNATNNATQVNASDIFGKLEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKI 144
Query: 3435 RHRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVA 3256
R +F ++++ Q GWFD + G + T+L D + +I EGIGDK+G+ + A ++
Sbjct: 145 RQKFFHAIMNQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIG 204
Query: 3255 YIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAF 3076
+ W+L ++L ++P + + A+ ++S T KEL KAG++AEE L +RTV AF
Sbjct: 205 FTRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELQAYAKAGAVAEEVLAAIRTVIAF 264
Query: 3075 NGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIIT 2896
GQ++ + RY LE+ ++ + K YG L+ +
Sbjct: 265 GGQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLV-ISKEY 323
Query: 2895 TPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQ 2716
+ G V V ++L+GA+ +G SP++ NAR +A I+ ID P ID +SK G +
Sbjct: 324 SIGQVLTVFFAVLIGAFSIGQASPNIEAFANARGAAYEIFNIIDNKPSIDSFSKNGYKPD 383
Query: 2715 NVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEP 2536
N+ G ++F+N+HF YPSRKD +IL GLNL V+ G +VALVG+SGCGKST+V LL RLY+P
Sbjct: 384 NIKGNLEFKNIHFSYPSRKDVQILKGLNLKVQSGQTVALVGNSGCGKSTTVQLLQRLYDP 443
Query: 2535 EAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKM 2356
G V+IDG D+R +N+ +LR +G+V QEP+LF TI N+ G T + + + K
Sbjct: 444 TEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKE 503
Query: 2355 ANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSE 2176
ANA+DFI K+P +DTL+G+ G QLSGGQKQR+AIAR L+R+PK+LLLDEATSALD +SE
Sbjct: 504 ANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESE 563
Query: 2175 SIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLV 1996
++VQ+AL+ A +GRTTI+IAHRLST+R AD I F+ GVIVE GNHEEL+R G YF LV
Sbjct: 564 AVVQAALDKAREGRTTIVIAHRLSTVRNADIIAGFDGGVIVEQGNHEELMREKGIYFKLV 623
Query: 1995 KAQQFKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRS 1816
Q EI+L + E N +++ SK S
Sbjct: 624 MTQ-----------TAGNEIELGN-----------------EVGESKNEIDNLDMSSKDS 655
Query: 1815 XXXXXXXXXXXXXXXXXXXEDGQITA-----------GYLDIFKNAKGNYLYMFLGTVFA 1669
+D +++ + I K + Y +G A
Sbjct: 656 ASSLIRRRSTRRSIRGPHDQDRKLSTKEALDEDVPPISFWRILKLNSSEWPYFVVGIFCA 715
Query: 1668 LIRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFA 1489
++ G PA ++IF V FT H + + F +GV + + F
Sbjct: 716 IVNGALQPAFSIIFSKVVGVFTRNTDDETKRHDSNLFSLLFLILGVISFITFFLQGFTFG 775
Query: 1488 VVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXX 1309
E L+ R R F+++L QD S+FDNP + G L TRLA+DA +K AR+ +
Sbjct: 776 KAGEILTKRLRYMVFKSMLRQDVSWFDNPKNTTGALTTRLANDAGQVKGATGARLAVITQ 835
Query: 1308 XXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQN----DDAGR 1141
IY WQ + + I ++ +++ + +++ + +G+
Sbjct: 836 NIANLGTGIIISLIYGWQ---LTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGK 892
Query: 1140 IAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCF 961
IA E IEN +T+ LTR + F + Y S + R+ LKK + I +S TQ+ MYF
Sbjct: 893 IATEAIENFRTVVSLTREQKFENMYAQSLQIPYRNALKKAHVFGITFSFTQAMMYFSYAA 952
Query: 960 TYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRK 781
+ G ++ + + ++ A++ GA+AV + + P++ KAK +A + II +
Sbjct: 953 CFRFGAYLVARELMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKAKVSASHIIMIIEKV 1012
Query: 780 PRTGDLMEGD-RPE-IRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSG 607
P G +P + GN+ F V F+YP RP P+++GL +GQT+ALVG SG G
Sbjct: 1013 PSIDSYSTGGLKPNTLEGNVKFNEVVFNYPTRPDIPVLQGLNLEVKKGQTLALVGSSGCG 1072
Query: 606 KSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG- 430
KST + +LERFYD G + +DG+++ +L++ LR + +V QEP LF +I EN+ G
Sbjct: 1073 KSTVVQLLERFYDPMAGTVFLDGKEVNQLNVQWLRAHLGIVSQEPILFDCSIAENIAYGD 1132
Query: 429 -LKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPK 253
+ V ++I +A + AN ++F+ +LP +T VG+KG QLSGGQKQRIAIARALVR P
Sbjct: 1133 NSRVVSQDEIERAAKEANIHQFIESLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPH 1192
Query: 252 ILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAG 73
ILLLDEATSALD+ESE+ VQEALD+AREGRTCI IAHRLS+IQN+DLIV I GKV+E G
Sbjct: 1193 ILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGKVKEHG 1252
Query: 72 NHTQLMHQKGRYYKLIKKQ 16
H QL+ QKG Y+ ++ Q
Sbjct: 1253 THQQLLAQKGIYFSMVSVQ 1271
>gi|22759019|gb|AAN05645.1| multidrug resistance p-glycoprotein [Canis
familiaris]
Length = 1281
Score = 815 bits (2105), Expect = 0.0
Identities = 488/1273 (38%), Positives = 709/1273 (55%), Gaps = 29/1273 (2%)
Frame = -1
Query: 3747 NQQLEAQP-VSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALL---- 3583
N++ E +P VS +FRY D L + +GT+ AII G + P++ LV G +T++
Sbjct: 25 NEKKEKKPTVSTFAMFRYSNWLDRLYMLVGTMAAIIHGAALPLMMLVFGNMTDSFANAGI 84
Query: 3582 ----VYPP--------TSKQFRNKANENV----YIFLGIGIFISITNFIQYMCFQHCCTR 3451
+P ++ F N E + Y + GIG + + +IQ + R
Sbjct: 85 SRNKAFPVIINESITNNTQHFINHLEEEMTTYAYYYSGIGAGVLVAAYIQVSFWCLAAGR 144
Query: 3450 VMAQMRHRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIA 3271
+ ++R +F ++++RQ GWFD + G + T+L D + +I EGIGDK+G+ A
Sbjct: 145 QILKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFHSIATFFT 204
Query: 3270 AIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVR 3091
+V + W+L ++L ++P + ++ A+ ++S T KEL+ KAG++AEE L +R
Sbjct: 205 GFIVGFTRGWKLTLVILAISPVLGLSAAIWAKILSSFTDKELLAYAKAGAVAEEVLAAIR 264
Query: 3090 TVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLK 2911
TV AF GQ++ + RY LE+ + + K YG L+
Sbjct: 265 TVIAFGGQKKELERYNKNLEEAKGIGIKKAITANISIGAAFLLIYASYALAFWYGTSLVL 324
Query: 2910 VGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKA 2731
+ G V V S+L+GA+ +G SP + NAR +A I++ ID P ID YSK+
Sbjct: 325 SSEYSI-GQVLTVFFSVLIGAFSIGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKS 383
Query: 2730 GKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLT 2551
G + N+ G ++F+NVHF YPSRK+ KIL GLNL V+ G +VALVG+SGCGKST+V L+
Sbjct: 384 GHKPDNIKGNLEFKNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQ 443
Query: 2550 RLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMI 2371
RLY+P G V IDG D+R +N+ LR G+V QEP+LF TI N+ G T + +
Sbjct: 444 RLYDPTDGMVCIDGQDIRTINVRHLREITGVVSQEPVLFATTIAENIRYGRENVTMDEIE 503
Query: 2370 EVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSAL 2191
+ K ANA+DFI K+P +DTL+G+ G QLSGGQKQR+AIAR L+R+PK+LLLDEATSAL
Sbjct: 504 KAVKEANAYDFIMKLPNKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSAL 563
Query: 2190 DAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGR 2011
D +SE++VQ AL+ A KGRTTI+IAHRLST+R AD I F+ GVIVE GNH+EL++ G
Sbjct: 564 DTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGI 623
Query: 2010 YFDLVKAQQFKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFS 1831
YF LV Q EI+L++ ++ G+SL S
Sbjct: 624 YFKLVTMQ-----------TRGNEIELENATGESKSESDALEMSPKDS---GSSLIKRRS 669
Query: 1830 GSKRSXXXXXXXXXXXXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLE 1651
++RS + + I K + Y +G A+I G
Sbjct: 670 -TRRS--IHAPQGQDRKLGTKEDLNENVPPVSFWRILKLNSTEWPYFVVGIFCAIINGGL 726
Query: 1650 LPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENL 1471
PA ++IF + FT M + F +G+ + + F E L
Sbjct: 727 QPAFSIIFSRIIGIFTRDEDPETKRQNSNMFSVLFLVLGIISFITFFLQGFTFGKAGEIL 786
Query: 1470 SMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXX 1291
+ R R FR++L QD S+FD+P + G L TRLA+DA +K + +R+ +
Sbjct: 787 TKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLG 846
Query: 1290 XXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQN----DDAGRIAIEII 1123
IY WQ + + I ++ +++ + +++ + AG+IA E I
Sbjct: 847 TGIIISLIYGWQ---LTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAI 903
Query: 1122 ENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGI 943
EN +T+ LTR + F Y S + R+ L+K I +++S+TQ+ MYF + G
Sbjct: 904 ENFRTVVSLTREQKFEYMYAQSLQVPYRNSLRKAHIFGVSFSITQAMMYFSYAGCFRFGA 963
Query: 942 RIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDL 763
++ + D A++ GA+AV + + P++ KAK +A + II + P
Sbjct: 964 YLVANEFMNFQDVLLVFSAIVFGAMAVGQVSSFAPDYAKAKVSAAHVIMIIEKSPLIDSY 1023
Query: 762 M-EGDRPE-IRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIG 589
G +P + GN+ F V F+YP RP P+++GL +GQT+ALVG SG GKST +
Sbjct: 1024 SPHGLKPNTLEGNVTFNEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQ 1083
Query: 588 MLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG--LKDVP 415
+LERFYD G++ IDG++I+ L++ LR + +V QEP LF +I EN+ G + V
Sbjct: 1084 LLERFYDPLAGSVLIDGKEIKHLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVS 1143
Query: 414 LEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDE 235
E+I QA + AN + F+ LP +T VG+KG QLSGGQKQRIAIARALVR P ILLLDE
Sbjct: 1144 HEEIMQAAKEANIHHFIETLPEKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDE 1203
Query: 234 ATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLM 55
ATSALD+ESE+ VQEALD+AREGRTCI IAHRLS+IQN+DLIV GKV+E G H QL+
Sbjct: 1204 ATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGKVKEHGTHQQLL 1263
Query: 54 HQKGRYYKLIKKQ 16
QKG Y+ ++ Q
Sbjct: 1264 AQKGIYFSMVSVQ 1276
>gi|2852441|gb|AAC02113.1| multidrug resistance p-glycoprotein [Canis
familiaris]
Length = 1280
Score = 815 bits (2105), Expect = 0.0
Identities = 488/1272 (38%), Positives = 711/1272 (55%), Gaps = 29/1272 (2%)
Frame = -1
Query: 3744 QQLEAQP-VSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALL----- 3583
++ E +P VS +FRY D L + +GT+ AII G + P++ LV G +T++
Sbjct: 25 EKKEKKPTVSTFAMFRYSNWLDRLYMLVGTMAAIIHGAALPLMMLVFGNMTDSFANAGIS 84
Query: 3582 ---VYPP--------TSKQFRNKANENV----YIFLGIGIFISITNFIQYMCFQHCCTRV 3448
+P ++ F N E + Y + GIG + + +IQ + R
Sbjct: 85 RNKTFPVIINESITNNTQHFINHLEEEMTTYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQ 144
Query: 3447 MAQMRHRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAA 3268
+ ++R +F ++++RQ GWFD + G + T+L D + +I EGIGDK+G+ + A
Sbjct: 145 ILKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKVGMFFQSIATFFTG 204
Query: 3267 IVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRT 3088
+V + W+L ++L ++P + ++ A+ ++S T KEL+ KAG++AEE L +RT
Sbjct: 205 FIVGFTPGWKLTLVILAISPVLGLSAAIWAKILSSFTDKELLAYAKAGAVAEEVLAAIRT 264
Query: 3087 VQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKV 2908
V AF GQ++ + RY LE+ ++ + K YG L+
Sbjct: 265 VIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTSLVLS 324
Query: 2907 GIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAG 2728
T G V V S+L+GA+ +G SP + NAR +A I++ ID P ID YSK+G
Sbjct: 325 SEYTI-GQVLTVFFSVLIGAFSIGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSG 383
Query: 2727 KRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTR 2548
+ N+ G ++F+NVHF YPSRK+ KIL GLNL V+ G +VALVG+SGCGKST+V L+ R
Sbjct: 384 HKPDNIKGNLEFKNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQR 443
Query: 2547 LYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIE 2368
LY+P G V IDG D+R +N+ LR G+V QEP+LF TI N+ G T + + +
Sbjct: 444 LYDPTDGMVCIDGQDIRTINVRHLREITGVVSQEPVLFATTIAENIRYGRENVTMDEIEK 503
Query: 2367 VCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALD 2188
K ANA+DFI K+P +DTL+G+ G +LSGGQKQR+AIAR L+R+PK+LLLDEATSALD
Sbjct: 504 AVKEANAYDFIMKLPNKFDTLVGERGARLSGGQKQRIAIARALVRNPKILLLDEATSALD 563
Query: 2187 AQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRY 2008
+SE++VQ AL+ A KGRTTI+IAHRLST+R AD I F+ GVIVE GNH+EL++ G Y
Sbjct: 564 TESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIY 623
Query: 2007 FDLVKAQQFKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSG 1828
F LV Q EI+L++ ++ G+SL S
Sbjct: 624 FKLVTMQ-----------TRGNEIELENATGESKSESDALEMSPKDS---GSSLIKRRS- 668
Query: 1827 SKRSXXXXXXXXXXXXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLEL 1648
++RS + + + I K + Y +G A+I G
Sbjct: 669 TRRS--IHAPQGQDRKLGTKEDLNENVPSVSFWRILKLNSTEWPYFVVGIFCAIINGGLQ 726
Query: 1647 PALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLS 1468
PA ++IF + FT M + F +G+ + + F E L+
Sbjct: 727 PAFSIIFSRIIGIFTRDEDPETKRQNSNMFSVLFLVLGIISFITFFLQGFTFGKAGEILT 786
Query: 1467 MRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXX 1288
R R FR++L QD S+FD+P + G L TRLA+DA +K + +R+ +
Sbjct: 787 KRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGT 846
Query: 1287 XXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQN----DDAGRIAIEIIE 1120
IY WQ + + I ++ +++ + +++ + AG+IA E IE
Sbjct: 847 GIIISLIYGWQ---LTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIE 903
Query: 1119 NVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIR 940
N +T+ LTR + F Y S + R+ L+K I +++S+TQ+ MYF + G
Sbjct: 904 NFRTVVSLTREQKFEYMYAQSLQVPYRNSLRKAHIFGVSFSITQAMMYFSYAGCFRFGAY 963
Query: 939 IIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLM 760
++ + D A++ GA+AV + + P++ KAK +A + II + P
Sbjct: 964 LVANEFMNFQDVLLVFSAIVFGAMAVGQVSSFAPDYAKAKVSAAHVIMIIEKSPLIDSYS 1023
Query: 759 -EGDRPE-IRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGM 586
G +P + GN+ F V F+YP RP P+++GL +GQT+ALVG SG GKST + +
Sbjct: 1024 PHGLKPNTLEGNVTFNEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQL 1083
Query: 585 LERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG--LKDVPL 412
LERFYD G++ IDG++I+ L++ LR + +V QEP LF +I EN+ G + V
Sbjct: 1084 LERFYDPLAGSVLIDGKEIKHLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSH 1143
Query: 411 EKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEA 232
E+I QA + AN + F+ LP +T VG+KG QLSGGQKQRIAIARALVR P ILLLDEA
Sbjct: 1144 EEIMQAAKEANIHHFIETLPEKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEA 1203
Query: 231 TSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMH 52
TSALD+ESE+ VQEALD+AREGRTCI IAHRLS+IQN+DLIV GKV+E G H QL+
Sbjct: 1204 TSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGKVKEHGTHQQLLA 1263
Query: 51 QKGRYYKLIKKQ 16
QKG Y+ +I Q
Sbjct: 1264 QKGIYFSMISVQ 1275
>gi|31442763|gb|AAN07780.2| multidrug resistance p-glycoprotein
[Macaca fascicularis]
Length = 1283
Score = 811 bits (2096), Expect = 0.0
Identities = 483/1268 (38%), Positives = 704/1268 (55%), Gaps = 32/1268 (2%)
Frame = -1
Query: 3723 VSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVT----NALLVYPPTSKQF 3556
VS+ +FRY D L + +GT+ AII G P++ LV G +T NA + + F
Sbjct: 34 VSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGDMTDTFANAGNLGDLGALLF 93
Query: 3555 RNKANENV-----------------YIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHR 3427
N + N+ Y + GIG + + +IQ + R + ++R +
Sbjct: 94 NNTNSSNITDTVPVMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQ 153
Query: 3426 FVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIY 3247
F ++++RQ GWFD + G + T+L D + +I EGIGDK+G+ + A +V +
Sbjct: 154 FFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTR 213
Query: 3246 EWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQ 3067
W+L ++L ++P + ++ A+ ++S T KEL+ KAG++AEE L +RTV AF GQ
Sbjct: 214 GWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQ 273
Query: 3066 EEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPG 2887
++ + RY LE+ ++ + K YG L+ + + G
Sbjct: 274 KKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLV-LSKEYSIG 332
Query: 2886 DVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVV 2707
V V S+L+GA+ +G SP + NAR +A I++ ID P ID YSK+G + N+
Sbjct: 333 QVLTVFFSVLIGAFSVGQASPSIEAFANARGAAFEIFKIIDNKPSIDSYSKSGHKPDNIK 392
Query: 2706 GRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAG 2527
G ++F NVHF YPSRK+ KIL GLNL V+ G +VALVG+SGCGKST+V L+ RLY+P G
Sbjct: 393 GNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEG 452
Query: 2526 NVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANA 2347
V++DG D+R +N+ +LR +G+V QEP+LF TI N+ G T + + + K ANA
Sbjct: 453 MVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANA 512
Query: 2346 HDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIV 2167
+DFI K+P+ +DTL+G+ G QLSGGQKQR+AIAR L+R+PK+LLLDEATSALD +SE++V
Sbjct: 513 YDFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVV 572
Query: 2166 QSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQ 1987
Q AL+ A KGRTTI+IAHRLST+R AD I F+ GVIVE GNH+EL++ G YF LV Q
Sbjct: 573 QVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQ 632
Query: 1986 QFKADPXXXXXXXXXEIDLD---DTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRS 1816
EI+L+ D + R S S GS+
Sbjct: 633 -----------TAGNEIELENAADESKSEIDTLEMSSHDSGSSLIRKRSTRRSVRGSQ-- 679
Query: 1815 XXXXXXXXXXXXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALA 1636
++ + I K + Y +G A+I G PA A
Sbjct: 680 -------GQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFA 732
Query: 1635 LIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFR 1456
+IF + FT + + F +G+ + + F E L+ R R
Sbjct: 733 VIFSKIIGIFTRNDDAETKRQNSNLFSLLFLVLGIVSFITFFLQGFTFGKAGEILTKRLR 792
Query: 1455 VQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXX 1276
FR++L QD S+FD+P + G L TRLA+DA +K + +R+ +
Sbjct: 793 YMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAIITQNIANLGTGIII 852
Query: 1275 XXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQN----DDAGRIAIEIIENVKT 1108
IY WQ + + I ++ +++ + +++ + AG+IA E IEN +T
Sbjct: 853 SLIYGWQ---LTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRT 909
Query: 1107 IQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQ 928
+ LT+ + F Y S + R+ L+K I I +S TQ+ MYF + G ++
Sbjct: 910 VVSLTQEQKFEHMYDQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAH 969
Query: 927 GDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDL-MEGD 751
S +D A++ GA+AV + + P++ KAK +A + II + P EG
Sbjct: 970 SLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKVSAAHIIMIIEKTPLIDSYSTEGL 1029
Query: 750 RPE-IRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERF 574
+P + GN+ F V F+YP R P+++GL +GQT+ALVG SG GKST + +LERF
Sbjct: 1030 KPNTLEGNVTFNEVVFNYPTRLDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERF 1089
Query: 573 YDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG--LKDVPLEKIN 400
YD G + +DG++I++L++ LR + +V QEP LF +I EN+ G + V E+I
Sbjct: 1090 YDPLAGKVLLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSISENIAYGDNSRVVSQEEIV 1149
Query: 399 QALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSAL 220
+A + AN + F+ +LP T VG+KG QLSGGQKQRIAIARALVR P ILLLDEATSAL
Sbjct: 1150 RAAKEANIHAFIESLPNKYSTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSAL 1209
Query: 219 DSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGR 40
D+ESE+ VQEALD+AREGRTCI IAHRLS+IQN+DLIV G+V+E G H QL+ QKG
Sbjct: 1210 DTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGI 1269
Query: 39 YYKLIKKQ 16
Y+ ++ Q
Sbjct: 1270 YFSMVSVQ 1277
>gi|72477|pir||DVHY1C multidrug resistance protein 1 - Chinese hamster
gi|191155|gb|AAA37004.1| p-glycoprotein
Length = 1276
Score = 811 bits (2094), Expect = 0.0
Identities = 480/1279 (37%), Positives = 709/1279 (54%), Gaps = 36/1279 (2%)
Frame = -1
Query: 3744 QQLEAQPV-SIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPT 3568
++ E +PV S+ +FRY D L + +GT+ AII GV+ P++ LV G +T++
Sbjct: 25 EKKEKKPVVSVFTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLVFGDMTDSFASVGNI 84
Query: 3567 SKQFRNKANE----------------NVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQM 3436
N A + Y + GIG + I +IQ + R + ++
Sbjct: 85 PTNATNNATQVNASDIFGKLEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKI 144
Query: 3435 RHRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVA 3256
R +F ++++ Q GWFD + G + T+L D + +I EGIGDK+G+ + A ++
Sbjct: 145 RQKFFHAIMNQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIG 204
Query: 3255 YIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAF 3076
+ W+L ++L ++P + + A+ ++S T KEL KAG++AEE L +RTV AF
Sbjct: 205 FTRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELQAYAKAGAVAEEVLAAIRTVIAF 264
Query: 3075 NGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIIT 2896
GQ++ + RY LE+ ++ + K YG L+ +
Sbjct: 265 GGQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLV-ISKEY 323
Query: 2895 TPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQ 2716
+ G V V ++L+ + +G SP++ NAR +A I+ ID P ID +SK G +
Sbjct: 324 SIGQVLTVFFAVLIAPFSIGQASPNIEAFANARGAAYEIFNIIDNKPSIDSFSKNGYKPD 383
Query: 2715 NVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEP 2536
N+ G ++F+N+HF YPSRKD +IL GLNL V+ G +VALVG+SGCGKST+V LL RLY+P
Sbjct: 384 NIKGNLEFKNIHFSYPSRKDVQILKGLNLKVQSGQTVALVGNSGCGKSTTVQLLQRLYDP 443
Query: 2535 EAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKM 2356
G V+IDG D+R +N+ +LR +G+V QEP+LF TI N+ G T + + + K
Sbjct: 444 TEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKE 503
Query: 2355 ANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSE 2176
ANA+DFI K+P +DTL+G+ G QLSGGQKQR+AIAR L+R+PK+LLLDEATSALD +SE
Sbjct: 504 ANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESE 563
Query: 2175 SIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLV 1996
++VQ+AL+ A +GRTTI+IAHRLST+R AD I F+ GVIVE GNHEEL+R G YF LV
Sbjct: 564 AVVQAALDKAREGRTTIVIAHRLSTVRNADIIAGFDGGVIVEQGNHEELMREKGIYFKLV 623
Query: 1995 KAQQFKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRS 1816
Q EI+L + E N +++ SK S
Sbjct: 624 MTQ-----------TAGNEIELGN-----------------EVGESKNEIDNLDMSSKDS 655
Query: 1815 XXXXXXXXXXXXXXXXXXXEDGQITA-----------GYLDIFKNAKGNYLYMFLGTVFA 1669
+D +++ + I K + Y +G A
Sbjct: 656 ASSLIRRRSTRRSIRGPHDQDRKLSTKEALDEDVPPISFWRILKLNSSEWPYFVVGIFCA 715
Query: 1668 LIRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFA 1489
++ G PA ++IF V FT H + + F +GV + + F
Sbjct: 716 IVNGALQPAFSIIFSKVVGVFTRNTDDETKRHDSNLFSLLFLILGVISFITFFLQGFTFG 775
Query: 1488 VVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXX 1309
E L+ R R F+++L QD S+FDNP + G L TRLA+DA +K AR+ +
Sbjct: 776 KAGEILTKRLRYMVFKSMLRQDVSWFDNPKNTTGALTTRLANDAGQVKGATGARLAVITQ 835
Query: 1308 XXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQN----DDAGR 1141
IY WQ + + I ++ +++ + +++ + +G+
Sbjct: 836 NIANLGTGIIISLIYGWQ---LTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGK 892
Query: 1140 IAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCF 961
IA E IEN +T+ LTR + F + Y S + R+ LKK + I +S TQ+ MYF
Sbjct: 893 IATEAIENFRTVVSLTREQKFENMYAQSLQIPYRNALKKAHVFGITFSFTQAMMYFSYAA 952
Query: 960 TYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRK 781
+ G ++ + + ++ A++ GA+AV + + P++ KAK +A + II +
Sbjct: 953 CFRFGAYLVARELMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKAKVSASHIIMIIEKV 1012
Query: 780 PRTGDLMEGD-RPE-IRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSG 607
P G +P + GN+ F V F+YP RP P+++GL +GQT+ALVG SG G
Sbjct: 1013 PSIDSYSTGGLKPNTLEGNVKFNEVVFNYPTRPDIPVLQGLNLEVKKGQTLALVGSSGCG 1072
Query: 606 KSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG- 430
KST + +LERFYD G + +DG+++ +L++ LR + +V QEP LF +I EN+ G
Sbjct: 1073 KSTVVQLLERFYDPMAGTVFLDGKEVNQLNVQWLRAHLGIVSQEPILFDCSIAENIAYGD 1132
Query: 429 -LKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPK 253
+ V ++I +A + AN ++F+ +LP +T VG+KG QLSGGQKQRIAIARALVR P
Sbjct: 1133 NSRVVSQDEIERAAKEANIHQFIESLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPH 1192
Query: 252 ILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAG 73
ILLLDEATSALD+ESE+ VQEALD+AREGRTCI IAHRLS+IQN+DLIV I GKV+E G
Sbjct: 1193 ILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGKVKEHG 1252
Query: 72 NHTQLMHQKGRYYKLIKKQ 16
H QL+ QKG Y+ ++ Q
Sbjct: 1253 THQQLLAQKGIYFSMVSVQ 1271
>gi|6755048|ref|NP_035206.1| ATP-binding cassette, sub-family B
(MDR/TAP), member 1A; P glycoprotein 3; ATP-binding
cassette, sub-family B (MDR/TAP), member 4; multi-drug
resistance 3; P-glycoprotein; multiple drug resistant 1a
[Mus musculus]
gi|387427|gb|AAA39514.1| P-glycoprotein
Length = 1276
Score = 810 bits (2092), Expect = 0.0
Identities = 477/1278 (37%), Positives = 718/1278 (55%), Gaps = 35/1278 (2%)
Frame = -1
Query: 3744 QQLEAQP-VSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPT 3568
++ E +P VS+ +FRY D L + +GT+ AII GV+ P++ L+ G +T++
Sbjct: 25 EKKEKKPAVSVLTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLIFGDMTDSFASVGNV 84
Query: 3567 SKQFRNKANEN---------------VYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMR 3433
SK N + + Y + GIG + I +IQ + R + ++R
Sbjct: 85 SKNSTNMSEADKRAMFAKLEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIR 144
Query: 3432 HRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAY 3253
+F ++++ Q GWFD + G + T+L D + +I EGIGDK+G+ + A ++ +
Sbjct: 145 QKFFHAIMNQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGF 204
Query: 3252 IYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFN 3073
W+L ++L ++P + + A+ ++S T KEL KAG++AEE L +RTV AF
Sbjct: 205 TRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELHAYAKAGAVAEEVLAAIRTVIAFG 264
Query: 3072 GQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITT 2893
GQ++ + RY LE+ ++ + K YG L+ + +
Sbjct: 265 GQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLV-ISKEYS 323
Query: 2892 PGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQN 2713
G V V S+L+GA+ +G SP++ NAR +A +++ ID P ID +SK+G + N
Sbjct: 324 IGQVLTVFFSVLIGAFSVGQASPNIEAFANARGAAYEVFKIIDNKPSIDSFSKSGHKPDN 383
Query: 2712 VVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPE 2533
+ G ++F+N+HF YPSRK+ +IL GLNL V+ G +VALVG+SGCGKST+V L+ RLY+P
Sbjct: 384 IQGNLEFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPL 443
Query: 2532 AGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMA 2353
G V+IDG D+R +N+ +LR +G+V QEP+LF TI N+ G T + + + K A
Sbjct: 444 DGMVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEA 503
Query: 2352 NAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSES 2173
NA+DFI K+P +DTL+G+ G +SGGQKQR+AIAR L+R+PK+LLLDEATSALD +SE+
Sbjct: 504 NAYDFIMKLPHQFDTLVGERGAHVSGGQKQRIAIARALVRNPKILLLDEATSALDTESEA 563
Query: 2172 IVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVK 1993
+VQ+AL+ A +GRTTI+IAHRLST+R AD I F+ GVIVE GNH+EL+R G YF LV
Sbjct: 564 VVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVM 623
Query: 1992 AQQFKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSX 1813
Q EI+L + EA + + +++ SK S
Sbjct: 624 TQ-----------TAGNEIELGN-----------------EACKSKDEIDNLDMSSKDSG 655
Query: 1812 XXXXXXXXXXXXXXXXXXEDGQIT-----------AGYLDIFKNAKGNYLYMFLGTVFAL 1666
+D +++ A + I K + Y +G A+
Sbjct: 656 SSLIRRRSTRKSICGPHDQDRKLSTKEALDEDVPPASFWRILKLNSTEWPYFVVGIFCAI 715
Query: 1665 IRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAV 1486
I G PA ++IF V FT + + F +G+ + + F
Sbjct: 716 INGGLQPAFSVIFSKVVGVFTNGGPPETQRQNSNLFSLLFLILGIISFITFFLQGFTFGK 775
Query: 1485 VSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXX 1306
E L+ R R F+++L QD S+FD+P + G L TRLA+DA +K +R+ +
Sbjct: 776 AGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGATGSRLAVIFQN 835
Query: 1305 XXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQN----DDAGRI 1138
IY WQ + + I ++ +++ + +++ + +G+I
Sbjct: 836 IANLGTGIIISLIYGWQ---LTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKI 892
Query: 1137 AIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFT 958
A E IEN +T+ LTR + F Y S + R+ +KK + I +S TQ+ MYF
Sbjct: 893 ATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNAMKKAHVFGITFSFTQAMMYFSYAAC 952
Query: 957 YAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKP 778
+ G ++ Q + ++ A++ GA+AV + + P++ KA +A + II + P
Sbjct: 953 FRFGAYLVTQQLMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKATVSASHIIRIIEKTP 1012
Query: 777 RTGDL-MEGDRPE-IRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGK 604
+G +P + GN+ F V F+YP RP P+++GL +GQT+ALVG SG GK
Sbjct: 1013 EIDSYSTQGLKPNMLEGNVQFSGVVFNYPTRPSIPVLQGLSLEVKKGQTLALVGSSGCGK 1072
Query: 603 STNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG-- 430
ST + +LERFYD G++ +DG++I++L++ LR Q+ +V QEP LF +I EN+ G
Sbjct: 1073 STVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDN 1132
Query: 429 LKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKI 250
+ V E+I +A + AN ++F+ +LP +T VG+KG QLSGGQKQRIAIARALVR P I
Sbjct: 1133 SRVVSYEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHI 1192
Query: 249 LLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGN 70
LLLDEATSALD+ESE+ VQEALD+AREGRTCI IAHRLS+IQN+DLIV I GKV+E G
Sbjct: 1193 LLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGT 1252
Query: 69 HTQLMHQKGRYYKLIKKQ 16
H QL+ QKG Y+ ++ Q
Sbjct: 1253 HQQLLAQKGIYFSMVSVQ 1270
>gi|48267183|gb|AAQ63650.3| multi-drug resistance P-glycoprotein 1;
PGY1; MDR1; GP170; ABC20; P-GP [Oryctolagus cuniculus]
Length = 1279
Score = 810 bits (2092), Expect = 0.0
Identities = 481/1283 (37%), Positives = 717/1283 (55%), Gaps = 40/1283 (3%)
Frame = -1
Query: 3744 QQLEAQP-VSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSG------------ 3604
++ E +P VS +FRY D L + +GT+ AII G + P++ LV G
Sbjct: 24 KEKEKRPTVSAFAMFRYSNWLDKLYMVVGTLAAIIHGAALPLMMLVFGDMTDSFSNPGNM 83
Query: 3603 ---RVTNALLVYPPTSKQFRNKANENV---YIFLGIGIFISITNFIQYMCFQHCCTRVMA 3442
+TN + S+ + + E Y + GIG + + +IQ + R
Sbjct: 84 IPANITNLNMSNISASEIYEHLEEEMTTYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQTF 143
Query: 3441 QMRHRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIV 3262
++R +F +S++RQ GWFD + G + T+L D + +I +GIGDK+G+ + + +
Sbjct: 144 KIRKQFFHSIMRQEIGWFDVHDVGELNTRLTDDVSKINDGIGDKIGMFFQSMSTFFTGFI 203
Query: 3261 VAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQ 3082
V + W+L ++L ++P + +L A+ M+S T KEL+ KAG++AEE L +RTV
Sbjct: 204 VGFTRGWKLTLVILAISPVLGLSAALWAKIMSSFTDKELLAYAKAGAVAEEVLAAIRTVI 263
Query: 3081 AFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYL--LKV 2908
AF GQ++ + RY LE+ ++ + K Y +L LK
Sbjct: 264 AFGGQQKELERYNKNLEEAKRIGIKKAITANISVGVAFLLMYASYALAFWYWNHLGHLKE 323
Query: 2907 GIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAG 2728
I G V V S+L+GA+ +G SP++ NAR +A I++ ID +P ID YS+AG
Sbjct: 324 YSI---GQVLTVFFSVLVGAFSIGQASPNVEAFANARGAAYEIFRIIDNMPSIDSYSEAG 380
Query: 2727 KRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTR 2548
+ N+ G ++F NVHF YPSRK+ KIL GLNL VE G +VALVG+SGCGKST+V L+ R
Sbjct: 381 HKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVESGQTVALVGNSGCGKSTTVQLMRR 440
Query: 2547 LYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIE 2368
LY+P G V+IDG D+R +N+ +LR G+V QEP+LF TI N+ G T + + +
Sbjct: 441 LYDPTDGVVSIDGQDIRTMNVRYLREITGVVSQEPVLFATTIAENVRYGREDVTMDEIEK 500
Query: 2367 VCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALD 2188
K ANA++FI K+P +DTL+G+ G QLSGGQKQR+AIAR L+R+PK+LLLDEATSALD
Sbjct: 501 AVKEANAYNFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALD 560
Query: 2187 AQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRY 2008
+SE++VQ AL+ A KGRTTI+IAHRLST+R AD I F+ GVIVE GNHEEL+R G Y
Sbjct: 561 TESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDNGVIVERGNHEELMRQKGVY 620
Query: 2007 FDLVKAQQFKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSG 1828
F LV Q EIDL+++ RG ++
Sbjct: 621 FRLVTMQ-----------TAGNEIDLENSASES----------------RGEKMDLVEMS 653
Query: 1827 SKRSXXXXXXXXXXXXXXXXXXXEDGQIT-----------AGYLDIFKNAKGNYLYMFLG 1681
+K S +DG+++ + I K + Y +G
Sbjct: 654 AKESGSSLIRRRSSHKSFHGAQGQDGKLSTTEAQNENVPPVSFWRIMKLNLTEWPYFLVG 713
Query: 1680 TVFALIRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASS 1501
+ A+I G PA A++F + FT + + F +G+ + +
Sbjct: 714 VICAIINGGLQPAFAVVFSKIVGVFTRNDDDETKRRNSDLFSLLFLILGIISFITFFLQG 773
Query: 1500 VLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARML 1321
F E L+ R R F+++L QD S+FD+P + G L TRLA+DA +K +R+
Sbjct: 774 FTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGATGSRLA 833
Query: 1320 QVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQN----D 1153
+ +Y WQ + + I ++ +++ + +++ +
Sbjct: 834 VIAQNIANLGTGIIISLVYGWQ---LTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELE 890
Query: 1152 DAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYF 973
+G+IA E IEN +T+ LTR + F + Y S + R+ L+K I I +S TQ+ MYF
Sbjct: 891 GSGKIATEAIENFRTVVSLTREQKFENMYAQSLQVPYRNSLEKAHIFGITFSFTQAMMYF 950
Query: 972 MMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNI 793
+ G ++ + S ++ A++ GA+AV + + P++ KAK +A + I
Sbjct: 951 SYAGCFRFGAFLVARELMSFENVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISASHIIMI 1010
Query: 792 IYRKPRTGDL-MEGDRP-EIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGP 619
+ + P+ EG +P + GN+ F++V F+YP RP P+++GL +GQT+ALVGP
Sbjct: 1011 LEKLPKIDSYSTEGLKPGTLEGNMTFKDVVFNYPTRPDIPVLQGLNLQVKKGQTLALVGP 1070
Query: 618 SGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENV 439
SG GKST + ++ERFYD G + +DG+++ +L++ LR + +V QEP LF +I EN+
Sbjct: 1071 SGCGKSTVVQLIERFYDPLAGTVLLDGKEVNQLNVQWLRAHLGIVSQEPILFDCSIAENI 1130
Query: 438 CLG--LKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALV 265
G + V ++I +A + AN + F+ +LP +T VG+KG QLSGGQKQRIAIARALV
Sbjct: 1131 AYGDNSRVVSQDEIIKAAKEANIHAFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALV 1190
Query: 264 RDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKV 85
R P ILLLDEATSA D+ESE+ VQEALD+AREGRTC+ IAHRLS+IQN+D+IV G+V
Sbjct: 1191 RQPHILLLDEATSAPDTESEKVVQEALDKAREGRTCVVIAHRLSTIQNADMIVVFQNGRV 1250
Query: 84 QEAGNHTQLMHQKGRYYKLIKKQ 16
+E G H QL+ QKG Y+ ++ Q
Sbjct: 1251 KECGTHHQLLAQKGIYFSMVSVQ 1273
>gi|46394984|gb|AAS91648.1| multidrug resistance protein;
P-glycoprotein [Macaca mulatta]
Length = 1283
Score = 810 bits (2091), Expect = 0.0
Identities = 483/1268 (38%), Positives = 702/1268 (55%), Gaps = 32/1268 (2%)
Frame = -1
Query: 3723 VSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVT----NALLVYPPTSKQF 3556
VS+ +FRY D L + +GT+ AII G P++ LV G +T NA + + F
Sbjct: 34 VSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGDMTDTFANAGNLGDLGALLF 93
Query: 3555 RNKANENV-----------------YIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHR 3427
N + N+ Y + GIG + + +IQ + R + ++R +
Sbjct: 94 NNTNSSNITDTVPVMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQ 153
Query: 3426 FVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIY 3247
F ++++RQ GWFD + G + T+L D + +I EGIGDK+G+ + A +V +
Sbjct: 154 FFHAIMRQEIGWFDVHDVGELNTRLTDEVSKINEGIGDKIGMFFQSMATFFTGFIVGFTR 213
Query: 3246 EWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQ 3067
W+L ++L ++P + + A+ ++S T KEL+ KAG +AEE L +RTV AF GQ
Sbjct: 214 GWKLTLVILAISPILGLSAAAWAKILSSFTDKELLAYAKAGVVAEEVLAAIRTVIAFGGQ 273
Query: 3066 EEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPG 2887
++ + RY LE+ ++ + K YG L+ + + G
Sbjct: 274 KKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLV-LSKEYSIG 332
Query: 2886 DVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVV 2707
V V S+L+GA+ +G SP + NAR +A I++ ID P ID YSK+G + N+
Sbjct: 333 QVLTVFFSVLIGAFSVGQASPSIEAFANARGAAFEIFKIIDNKPSIDSYSKSGHKPDNIK 392
Query: 2706 GRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAG 2527
G ++F NVHF YPSRK+ KIL GLNL V+ G +VALVG+SGCGKST+V L+ RLY+P G
Sbjct: 393 GNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEG 452
Query: 2526 NVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANA 2347
V++DG D+R +N+ +LR +G+V QEP+LF TI N+ G T + + + K ANA
Sbjct: 453 MVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANA 512
Query: 2346 HDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIV 2167
+DFI K+P+ +DTL+G+ G QLSGGQKQR+AIAR L+R+PK+LLLDEATSALD +SE++V
Sbjct: 513 YDFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVV 572
Query: 2166 QSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQ 1987
Q AL+ A KGRTTI+IAHRLST+R AD I F+ GVIVE GNH+EL++ G YF LV Q
Sbjct: 573 QVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQ 632
Query: 1986 QFKADPXXXXXXXXXEIDLD---DTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRS 1816
EI+L+ D + R S S GS+
Sbjct: 633 -----------TAGNEIELENAADESKSEIDTLEMSSHDSGSSLIRKRSTRRSVRGSQ-- 679
Query: 1815 XXXXXXXXXXXXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALA 1636
++ + I K + Y +G A+I G PA A
Sbjct: 680 -------GQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFA 732
Query: 1635 LIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFR 1456
+IF + FT + + F +G+ + + F E L+ R R
Sbjct: 733 VIFSKIIGIFTRNDDAETKQQNSNLFSLLFLVLGIVSFITFFLQGFTFGKAGEILTKRLR 792
Query: 1455 VQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXX 1276
FR++L QD S+FD+P + G L TRLA+DA +K + +R+ +
Sbjct: 793 YMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAIITQNIANLGTGIII 852
Query: 1275 XXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQN----DDAGRIAIEIIENVKT 1108
IY WQ + + I ++ +++ + +++ + AG+IA E IEN +T
Sbjct: 853 SLIYGWQ---LTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRT 909
Query: 1107 IQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQ 928
+ LT+ + F Y S + R+ L+K I I +S TQ+ MYF + G ++
Sbjct: 910 VVSLTQEQKFEHMYDQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAH 969
Query: 927 GDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDL-MEGD 751
S +D A++ GA+AV + + P++ KAK +A + II + P EG
Sbjct: 970 SLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKVSAAHIIMIIEKTPLIDSYSTEGL 1029
Query: 750 RPE-IRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERF 574
+P + GN+ F V F+YP R P+++GL +GQT+ALVG SG GKST + +LERF
Sbjct: 1030 KPNTLEGNVTFNEVVFNYPTRLDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERF 1089
Query: 573 YDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG--LKDVPLEKIN 400
YD G + +DG++I++L++ LR + +V QEP LF +I EN+ G + V E+I
Sbjct: 1090 YDPLAGKVLLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSISENIAYGDNSRVVSQEEIV 1149
Query: 399 QALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSAL 220
+A + AN + F+ +LP T VG+KG QLSGGQKQRIAIARALVR P ILLLDEATSAL
Sbjct: 1150 RAAKEANIHAFIESLPNKYSTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSAL 1209
Query: 219 DSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGR 40
D+ESE+ VQEALD+AREGRTCI IAHRLS+IQN+DLIV G+V+E G H QL+ QKG
Sbjct: 1210 DTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGI 1269
Query: 39 YYKLIKKQ 16
Y+ ++ Q
Sbjct: 1270 YFSMVSVQ 1277
>gi|266517|sp|P21447|MDR3_MOUSE Multidrug resistance protein 3
(P-glycoprotein 3) (MDR1A)
gi|110720|pir||A34786 multidrug resistance protein 1a - mouse
gi|387429|gb|AAA39517.1| multidrug resistance protein
Length = 1276
Score = 809 bits (2089), Expect = 0.0
Identities = 477/1278 (37%), Positives = 717/1278 (55%), Gaps = 35/1278 (2%)
Frame = -1
Query: 3744 QQLEAQP-VSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPT 3568
++ E +P VS+ +FRY D L + +GT+ AII GV+ P++ L+ G +T++
Sbjct: 25 EKKEKKPAVSVLTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLIFGDMTDSFASVGNV 84
Query: 3567 SKQFRNKANEN---------------VYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMR 3433
SK N + + Y + GIG + I +IQ + R + ++R
Sbjct: 85 SKNSTNMSEADKRAMFAKLEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIR 144
Query: 3432 HRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAY 3253
+F ++++ Q GWFD + G + T+L D + +I EGIGDK+G+ + A ++ +
Sbjct: 145 QKFFHAIMNQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGF 204
Query: 3252 IYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFN 3073
W+L ++L ++P + + A+ ++S T KEL KAG++AEE L +RTV AF
Sbjct: 205 TRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELHAYAKAGAVAEEVLAAIRTVIAFG 264
Query: 3072 GQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITT 2893
GQ++ + RY LE+ ++ + K YG L+ + +
Sbjct: 265 GQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLV-ISKEYS 323
Query: 2892 PGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQN 2713
G V V S+L+GA+ +G SP++ NAR +A +++ ID P ID +SK+G + N
Sbjct: 324 IGQVLTVFFSVLIGAFSVGQASPNIEAFANARGAAYEVFKIIDNKPSIDSFSKSGHKPDN 383
Query: 2712 VVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPE 2533
+ G ++F+N+HF YPSRK+ +IL GLNL V+ G +VALVG+SGCGKST+V L+ RLY+P
Sbjct: 384 IQGNLEFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPL 443
Query: 2532 AGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMA 2353
G V+IDG D+R +N+ +LR +G+V QEP+LF TI N+ G T + + + K A
Sbjct: 444 DGMVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEA 503
Query: 2352 NAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSES 2173
NA+DFI K+P +DTL+G+ G QLSGGQKQR+AIAR L+R+PK+LLLDEATSALD +SE+
Sbjct: 504 NAYDFIMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEA 563
Query: 2172 IVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVK 1993
+VQ+AL+ A +GRTTI+IAHRLST+R AD I F+ GVIVE GNH+EL+R G YF LV
Sbjct: 564 VVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVM 623
Query: 1992 AQQFKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSX 1813
Q EI+L + EA + + +++ SK S
Sbjct: 624 TQ-----------TAGNEIELGN-----------------EACKSKDEIDNLDMSSKDSG 655
Query: 1812 XXXXXXXXXXXXXXXXXXEDGQIT-----------AGYLDIFKNAKGNYLYMFLGTVFAL 1666
+D +++ A + I K + Y +G A+
Sbjct: 656 SSLIRRRSTRKSICGPHDQDRKLSTKEALDEDVPPASFWRILKLNSTEWPYFVVGIFCAI 715
Query: 1665 IRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAV 1486
I G PA ++IF V FT + + F +G+ + + F
Sbjct: 716 INGGLQPAFSVIFSKVVGVFTNGGPPETQRQNSNLFSLLFLILGIISFITFFLQGFTFGK 775
Query: 1485 VSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXX 1306
E L+ R R F+++L QD S+FD+P + G L TRLA+DA +K +R+ +
Sbjct: 776 AGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGATGSRLAVIFQN 835
Query: 1305 XXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQN----DDAGRI 1138
IY WQ + + I ++ +++ + +++ + +G+I
Sbjct: 836 IANLGTGIIISLIYGWQ---LTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKI 892
Query: 1137 AIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFT 958
A E IEN +T+ LTR + F Y S + R+ +KK + I + TQ+ MYF
Sbjct: 893 ATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNAMKKAHVFGITFFFTQAMMYFSYAAC 952
Query: 957 YAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKP 778
+ G ++ Q + ++ A++ GA+AV + + P++ KA +A + II + P
Sbjct: 953 FRFGAYLVTQQLMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKATVSASHIIRIIEKTP 1012
Query: 777 RTGDL-MEGDRPE-IRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGK 604
+G +P + GN+ F F+YP RP P+++GL +GQT+ALVG SG GK
Sbjct: 1013 EIDSYSTQGLKPNMLEGNVQFSGFVFNYPTRPSIPVLQGLSLEVKKGQTLALVGSSGCGK 1072
Query: 603 STNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG-- 430
ST + +LERFYD G++ +DG++I++L++ LR Q+ +V QEP LF +I EN+ G
Sbjct: 1073 STVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDN 1132
Query: 429 LKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKI 250
+ V E+I +A + AN ++F+ +LP +T VG+KG QLSGGQKQRIAIARALVR P I
Sbjct: 1133 SRVVSYEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHI 1192
Query: 249 LLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGN 70
LLLDEATSALD+ESE+ VQEALD+AREGRTCI IAHRLS+IQN+DLIV I GKV+E G
Sbjct: 1193 LLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGT 1252
Query: 69 HTQLMHQKGRYYKLIKKQ 16
H QL+ QKG Y+ ++ Q
Sbjct: 1253 HQQLLAQKGIYFSMVSVQ 1270
>gi|22775296|gb|AAN07779.1| multidrug resistance p-glycoprotein
[Macaca mulatta]
Length = 1283
Score = 809 bits (2089), Expect = 0.0
Identities = 482/1268 (38%), Positives = 702/1268 (55%), Gaps = 32/1268 (2%)
Frame = -1
Query: 3723 VSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVT----NALLVYPPTSKQF 3556
VS+ +FRY D L + +G + AII G P++ LV G +T NA + + F
Sbjct: 34 VSVFSMFRYSNWLDKLYMVVGILAAIIHGAGLPLMMLVFGDMTDTFANAGNLGDLGALLF 93
Query: 3555 RNKANENV-----------------YIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHR 3427
N + N+ Y + GIG + + +IQ + R + ++R +
Sbjct: 94 NNTNSSNITDTVPVMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQ 153
Query: 3426 FVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIY 3247
F ++++RQ GWFD + G + T+L D + +I EGIGDK+G+ + A +V +
Sbjct: 154 FFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTR 213
Query: 3246 EWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQ 3067
W+L ++L ++P + + A+ ++S T KEL+ KAG++AEE L +RTV AF GQ
Sbjct: 214 GWKLTLVILAISPVLGVSAAAWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQ 273
Query: 3066 EEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPG 2887
++ + RY LE+ ++ + K YG L+ + + G
Sbjct: 274 KKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLV-LSKEYSIG 332
Query: 2886 DVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVV 2707
V V S+L+GA+ +G SP + NAR +A I++ ID P ID YSK+G + N+
Sbjct: 333 QVLTVFFSVLIGAFSVGQASPSIEAFANARGAAFEIFKIIDNKPSIDSYSKSGHKPDNIK 392
Query: 2706 GRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAG 2527
G ++F NVHF YPSRK+ KIL GLNL V+ G +VALVG+SGCGKST+V L+ RLY+P G
Sbjct: 393 GNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEG 452
Query: 2526 NVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANA 2347
V++DG D+R +N+ +LR +G+V QEP+LF TI N+ G T + + + K ANA
Sbjct: 453 MVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANA 512
Query: 2346 HDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIV 2167
+DFI K+P+ +DTL+G+ G QLSGGQKQR+AIAR L+R+PK+LLLDEATSALD +SE++V
Sbjct: 513 YDFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVV 572
Query: 2166 QSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQ 1987
Q AL+ A KGRTTI+IAHRLST+R AD I F+ GVIVE GNH+EL++ G YF LV Q
Sbjct: 573 QVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQ 632
Query: 1986 QFKADPXXXXXXXXXEIDLD---DTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRS 1816
EI+L+ D + R S S GS+
Sbjct: 633 -----------TAGNEIELENAADESKSEIDTLEMSSHDSGSSLIRKRSTRRSVRGSQ-- 679
Query: 1815 XXXXXXXXXXXXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALA 1636
++ + I K + Y +G A+I G PA A
Sbjct: 680 -------GQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFA 732
Query: 1635 LIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFR 1456
+IF + FT + + F +G+ + + F E L+ R R
Sbjct: 733 VIFSKIIGIFTRNDDAETKRQNSNLFSLLFLVLGIVSFITFFLQGFTFGKAGEILTKRLR 792
Query: 1455 VQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXX 1276
FR++L QD S+FD+P + G L TRLA+DA +K + +R+ +
Sbjct: 793 YMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAIITQNIANLGTGIII 852
Query: 1275 XXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQN----DDAGRIAIEIIENVKT 1108
IY WQ + + I ++ +++ + +++ + AG+IA E IEN +T
Sbjct: 853 SLIYGWQ---LTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRT 909
Query: 1107 IQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQ 928
+ LT+ + F Y S + R+ L+K I I +S TQ+ MYF + G ++
Sbjct: 910 VVSLTQEQKFEHMYDQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAH 969
Query: 927 GDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDL-MEGD 751
S +D A++ GA+AV + + P++ KAK +A + II + P EG
Sbjct: 970 SLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKVSAAHIIMIIEKTPLIDSYSTEGL 1029
Query: 750 RPE-IRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERF 574
+P + GN+ F V F+YP R P+++GL +GQT+ALVG SG GKST + +LERF
Sbjct: 1030 KPNTLEGNVTFNEVVFNYPTRLDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERF 1089
Query: 573 YDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG--LKDVPLEKIN 400
YD G + +DG++I++L++ LR + +V QEP LF +I EN+ G + V E+I
Sbjct: 1090 YDPLAGKVLLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSISENIAYGDNSRVVSQEEIV 1149
Query: 399 QALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSAL 220
+A + AN + F+ +LP T VG+KG QLSGGQKQRIAIARALVR P ILLLDEATSAL
Sbjct: 1150 RAAKEANIHAFIESLPNKYSTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSAL 1209
Query: 219 DSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGR 40
D+ESE+ VQEALD+AREGRTCI IAHRLS+IQN+DLIV G+V+E G H QL+ QKG
Sbjct: 1210 DTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGI 1269
Query: 39 YYKLIKKQ 16
Y+ ++ Q
Sbjct: 1270 YFSMVSVQ 1277
>gi|25453370|ref|NP_036755.2| P-glycoprotein/multidrug resistance 1;
ATP-binding cassette, sub-family B (MDR/TAP), member 1
(P-glycoprotein/multidrug resistance 1); ATP-binding
cassette sub-family B (MDR/TAP) member 1
(P-glycoprotein/multidrug resistance 1) [Rattus
norvegicus]
gi|19743730|gb|AAL92458.1| ATP-binding cassette protein B1b [Rattus
norvegicus]
Length = 1275
Score = 808 bits (2086), Expect = 0.0
Identities = 476/1275 (37%), Positives = 719/1275 (56%), Gaps = 29/1275 (2%)
Frame = -1
Query: 3759 GDIANQQLEAQP-VSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALL 3583
G + ++ E +P V I G+FRY D L + +GT+ AII G P+L LV G +T++
Sbjct: 19 GKKSKKEKEKKPAVGIFGMFRYADWLDKLCMALGTLAAIIHGTLLPLLMLVFGYMTDSFT 78
Query: 3582 -----VYPPTSKQFRNKANENV-------------YIFLGIGIFISITNFIQYMCFQHCC 3457
+ P + Q + + V Y + GIG + I +IQ +
Sbjct: 79 QAETRILPSVTNQSEINSTQTVSDSSLEEDMAMYAYYYTGIGAGVLIVAYIQVSLWCLAA 138
Query: 3456 TRVMAQMRHRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAML 3277
R + ++R +F ++++ Q GWFD N +G + T+L D + +I +GIGDKLG+ +
Sbjct: 139 GRQIHKIRQKFFHAIMNQEIGWFDVNDAGELNTRLTDDVSKINDGIGDKLGMFFQSITTF 198
Query: 3276 IAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMG 3097
A ++ +I W+L ++L V+P + ++ A+ +TS T KEL KAG++AEE L
Sbjct: 199 SAGFIIGFISGWKLTLVILAVSPLIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEVLAA 258
Query: 3096 VRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYL 2917
+RTV AF GQ++ + RY LE+ ++ + K YG L
Sbjct: 259 IRTVIAFGGQKKELERYNKNLEEAKRVGIKKAITANISIGIAYLLVYASYALAFWYGTSL 318
Query: 2916 LKVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYS 2737
+ + G V V S+LLG + +G ++P++ NAR +A I++ ID P ID +S
Sbjct: 319 VLSNEYSI-GQVLTVFFSILLGTFSIGHLAPNIEAFANARGAAYEIFKIIDNEPSIDSFS 377
Query: 2736 KAGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGL 2557
G + +++G ++F+NV+F YPSR + KIL GLNL V+ G +VALVG+SGCGKST+V L
Sbjct: 378 TKGHKPDSIMGNLEFKNVYFNYPSRSEVKILKGLNLKVKSGQTVALVGNSGCGKSTTVQL 437
Query: 2556 LTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRET 2377
L RLY+P G V+IDG D+R +N+ +LR +G+V QEP+LF TI N+ G T +
Sbjct: 438 LQRLYDPIEGEVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDE 497
Query: 2376 MIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATS 2197
+ + K ANA+DFI K+P ++TL+G+ G QLSGGQKQR+AIAR L+R+PK+LLLDEATS
Sbjct: 498 IEKAVKEANAYDFIMKLPHKFNTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATS 557
Query: 2196 ALDAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLG 2017
ALD +SE++VQ+AL+ A +GRTTI+IAHRLST+R AD I F+ GVIVE GNHEEL++
Sbjct: 558 ALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEELMKEK 617
Query: 2016 GRYFDLVKAQQ--FKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLN 1843
G YF LV Q + +P DT + RR S++
Sbjct: 618 GIYFKLVMTQTRGNEIEPGNNAYESQ-----SDTGASELTSEKSKSPLIRRSIRR--SIH 670
Query: 1842 DSFSGSKRSXXXXXXXXXXXXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALI 1663
+R ++ + I K + Y+ +G + A+I
Sbjct: 671 RRQDQERR-------------LSSKEDVDEDVPMVSFWQILKLNISEWPYLVVGVLCAVI 717
Query: 1662 RGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVV 1483
G P A++F + F+ + + F +G+ + + F
Sbjct: 718 NGCIQPVFAIVFSKIVGVFSRDDDHETKQRNCNLFSLLFLVMGMISFVTYFFQGFAFGKA 777
Query: 1482 SENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXX 1303
E L+ R R F+++L QD S+FD+ + G L TRLASDA N+K + +R+ V
Sbjct: 778 GEILTKRLRYMVFKSMLRQDISWFDDHKNTTGSLTTRLASDASNVKGAMGSRLAVVTQNV 837
Query: 1302 XXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQN----DDAGRIA 1135
+Y WQ + +++G ++ L++ + +++ + +G+IA
Sbjct: 838 ANLGTGIILSLVYGWQ---LTLLLVVIIPLIVLGGIIEMKLLSGQALKDKKELEISGKIA 894
Query: 1134 IEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTY 955
E IEN +T+ LTR + F Y S + R+ LKK + I ++ TQ+ +YF +
Sbjct: 895 TEAIENFRTVVSLTREQKFETMYAQSLQIPYRNALKKAHVFGITFAFTQAMIYFSYAACF 954
Query: 954 AVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPR 775
G ++ + + ++ A++ GA+A N++ + P++ KAK +A + II + P
Sbjct: 955 RFGAYLVARELMTFENVMLVFSAVVFGAMAAGNTSSFAPDYAKAKVSASHIIRIIEKIPE 1014
Query: 774 TGDL-MEGDRPE-IRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKS 601
EG +P + GN+ F V F+YP RP P+++GL + +GQT+ALVG SG GKS
Sbjct: 1015 IDSYSTEGLKPNWLEGNVKFNGVMFNYPTRPNIPVLQGLSFEVKKGQTLALVGSSGCGKS 1074
Query: 600 TNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG--L 427
T + +LERFY+ G + +DG++I++L++ LR + +V QEP LF +I EN+ G
Sbjct: 1075 TVVQLLERFYNPMAGTVFLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSITENIAYGDNS 1134
Query: 426 KDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKIL 247
+ V E+I +A AN ++F+ +LP +T VG+KG QLSGGQKQRIAIARALVR P IL
Sbjct: 1135 RVVSHEEIVRAAREANIHQFIDSLPEKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHIL 1194
Query: 246 LLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNH 67
LLDEATSALD+ESE+ VQEALD+AREGRTCI IAHRLS+IQN+DLIV I G+V+E G H
Sbjct: 1195 LLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGQVKEHGTH 1254
Query: 66 TQLMHQKGRYYKLIK 22
QL+ QKG Y+ +++
Sbjct: 1255 QQLLAQKGIYFSMVQ 1269
Score = 363 bits (933), Expect = 1e-98
Identities = 204/567 (35%), Positives = 325/567 (56%), Gaps = 6/567 (1%)
Frame = -1
Query: 3672 LFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKANENVY--IFLGIGIFIS 3499
L +G +CA+I+G QP+ A+V ++ V+ + N N++ +FL +G+
Sbjct: 708 LVVGVLCAVINGCIQPVFAIVFSKIVG---VFSRDDDHETKQRNCNLFSLLFLVMGMISF 764
Query: 3498 ITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFD--KNHSGTITTKLNDSMERIRE 3325
+T F Q F + ++R+ S+LRQ+ WFD KN +G++TT+L ++
Sbjct: 765 VTYFFQGFAFGKAGEILTKRLRYMVFKSMLRQDISWFDDHKNTTGSLTTRLASDASNVKG 824
Query: 3324 GIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKEL 3145
+G +L V+ + A L I+++ +Y W+L +++ + P + + + ++ +K+
Sbjct: 825 AMGSRLAVVTQNVANLGTGIILSLVYGWQLTLLLVVIIPLIVLGGIIEMKLLSGQALKDK 884
Query: 3144 IGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXX 2965
+ +G IA E++ RTV + +++ Y L+ + A+ K
Sbjct: 885 KELEISGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNALKKAHVFGITFAFTQA 944
Query: 2964 XXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAA 2785
+GAYL+ ++T +V +V +++ GA G S A+VSA+
Sbjct: 945 MIYFSYAACFRFGAYLVARELMTFE-NVMLVFSAVVFGAMAAGNTSSFAPDYAKAKVSAS 1003
Query: 2784 SIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSV 2605
I + I+++P+ID YS G + + G VKF V F YP+R + +L GL+ V+ G ++
Sbjct: 1004 HIIRIIEKIPEIDSYSTEGLKPNWLEGNVKFNGVMFNYPTRPNIPVLQGLSFEVKKGQTL 1063
Query: 2604 ALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDT 2425
ALVG SGCGKST V LL R Y P AG V +DG ++++LN++WLR +GIV QEPILF+ +
Sbjct: 1064 ALVGSSGCGKSTVVQLLERFYNPMAGTVFLDGKEIKQLNVQWLRAHLGIVSQEPILFDCS 1123
Query: 2424 IHNNLLIGNPGS--TRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAI 2251
I N+ G+ + E ++ + AN H FI+ +P+ Y+T +GD G QLSGGQKQR+AI
Sbjct: 1124 ITENIAYGDNSRVVSHEEIVRAAREANIHQFIDSLPEKYNTRVGDKGTQLSGGQKQRIAI 1183
Query: 2250 ARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFF 2071
AR L+R P +LLLDEATSALD +SE +VQ AL+ A +GRT I+IAHRLSTI+ AD IV
Sbjct: 1184 ARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVI 1243
Query: 2070 EKGVIVEAGNHEELVRLGGRYFDLVKA 1990
+ G + E G H++L+ G YF +V+A
Sbjct: 1244 QNGQVKEHGTHQQLLAQKGIYFSMVQA 1270
Score = 321 bits (822), Expect = 1e-85
Identities = 209/588 (35%), Positives = 308/588 (51%), Gaps = 27/588 (4%)
Frame = -1
Query: 1698 LYMFLGTVFALIRGLELPALALIFGWVFEGFT-----FVPY--------------GGRMM 1576
L M LGT+ A+I G LP L L+FG++ + FT +P +
Sbjct: 47 LCMALGTLAAIIHGTLLPLLMLVFGYMTDSFTQAETRILPSVTNQSEINSTQTVSDSSLE 106
Query: 1575 HRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAH 1396
MAM + +G GV L+ + + + R + F ++ Q+ +FD +
Sbjct: 107 EDMAMYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFFHAIMNQEIGWFD--VN 164
Query: 1395 APGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLA 1216
G+L TRL D I + ++ I W+
Sbjct: 165 DAGELNTRLTDDVSKINDGIGDKLGMFFQSITTFSAGFIIGFISGWKLTLVILAVSP--- 221
Query: 1215 FVMIGLAYKI------SLMNVEQIQNDDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSS 1054
+IGL+ + S N E AG +A E++ ++T+ + + Y +
Sbjct: 222 --LIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNL 279
Query: 1053 KQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLG 874
++ KR +KK + I+ + +Y + G ++ + S +++LG
Sbjct: 280 EEAKRVGIKKAITANISIGIAYLLVYASYALAFWYGTSLVLSNEYSIGQVLTVFFSILLG 339
Query: 873 AVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLM-EGDRPE-IRGNILFENVKFSY 700
++ + A F A+ AA +F II +P +G +P+ I GN+ F+NV F+Y
Sbjct: 340 TFSIGHLAPNIEAFANARGAAYEIFKIIDNEPSIDSFSTKGHKPDSIMGNLEFKNVYFNY 399
Query: 699 PQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKL 520
P R I+KGL GQTVALVG SG GKST + +L+R YD G + IDGQDIR +
Sbjct: 400 PSRSEVKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEGEVSIDGQDIRTI 459
Query: 519 SLFHLRTQMALVGQEPRLFAGTIRENVCLGLKDVPLEKINQALELANANRFLANLPAGID 340
++ +LR + +V QEP LFA TI EN+ G ++V +++I +A++ ANA F+ LP +
Sbjct: 460 NVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFN 519
Query: 339 TDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRT 160
T VGE+G QLSGGQKQRIAIARALVR+PKILLLDEATSALD+ESE VQ ALD+AREGRT
Sbjct: 520 TLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRT 579
Query: 159 CITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQ 16
I IAHRLS+++N+D+I D G + E GNH +LM +KG Y+KL+ Q
Sbjct: 580 TIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEELMKEKGIYFKLVMTQ 627
>gi|126928|sp|P21449|MDR2_CRIGR Multidrug resistance protein 2
(P-glycoprotein 2)
gi|191167|gb|AAA68884.1| p-glycoprotein isoform II
Length = 1276
Score = 807 bits (2085), Expect = 0.0
Identities = 475/1266 (37%), Positives = 710/1266 (55%), Gaps = 25/1266 (1%)
Frame = -1
Query: 3744 QQLEAQPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALL-----V 3580
++ E V I G+FRY D L + +GT+ A++ G S P+L LV G +T++ +
Sbjct: 27 KEKENPNVGIFGMFRYADWLDKLYMVLGTLAAVLHGTSLPLLMLVFGNMTDSFTKAETSI 86
Query: 3579 YPPTSKQFRNKANENV------------YIFLGIGIFISITNFIQYMCFQHCCTRVMAQM 3436
+P + Q E + Y + GIG + I +IQ + R + ++
Sbjct: 87 WPNMTNQSEINNTEVISGSLEEDMATYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQINKI 146
Query: 3435 RHRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVA 3256
R +F ++++ Q GWFD + G + T+L D + +I +GIGDK+G+ + A +AA +V
Sbjct: 147 RQKFFHAIMNQEIGWFDVHDIGELNTRLTDDVSKINDGIGDKIGMFFQSIATFLAAFIVG 206
Query: 3255 YIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAF 3076
+I W+L ++L V+P + ++ A+ +TS T KEL KAG++AEE L +RTV AF
Sbjct: 207 FISGWKLTLVILAVSPLIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRTVIAF 266
Query: 3075 NGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIIT 2896
GQ + + RY LE+ + + K YG L+ +
Sbjct: 267 GGQNKELERYNKNLEEAKNVGIKKAVTANISIGIAYLLVYASYALAFWYGTSLVLSNEYS 326
Query: 2895 TPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQ 2716
G V V S+L G + +G I+P++ V NAR +A I++ ID P ID +S G +
Sbjct: 327 V-GQVLTVFFSILFGTFSIGHIAPNIEVFANARGAAYEIFKIIDNEPSIDSFSTQGHKPD 385
Query: 2715 NVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEP 2536
+V+G ++F+NVHF YPSR KIL GLNL V+ G +VALVG SGCGKST+V LL RLY+P
Sbjct: 386 SVMGNLEFKNVHFSYPSRSGIKILKGLNLKVQSGQTVALVGKSGCGKSTTVQLLQRLYDP 445
Query: 2535 EAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKM 2356
G V+IDG D+R +N+ +LR +G+V QEP+LF TI N+ G T + + + K
Sbjct: 446 TEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKE 505
Query: 2355 ANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSE 2176
ANA+DFI K+P +DTL+G+ G QLSGGQKQR+AIAR L+R+PK+LLLDEATSALD +SE
Sbjct: 506 ANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESE 565
Query: 2175 SIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLV 1996
++VQ+AL+ A +GRTTI+IAHRLST+R AD I F+ GVIVE GNHEEL++ G Y LV
Sbjct: 566 AVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEELMKEKGIYCRLV 625
Query: 1995 KAQQFKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRS 1816
Q + D + S + R+ S S GS+
Sbjct: 626 MMQ-------TRGNEVELGSEADGSQSDTIASELTSEEFKSPSVRK--STCRSICGSQ-- 674
Query: 1815 XXXXXXXXXXXXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALA 1636
++ + I K + Y+ +G + A+I G P +
Sbjct: 675 -------DQERRVSVKEAQDEDVPLVSFWGILKLNITEWPYLVVGVLCAVINGCMQPVFS 727
Query: 1635 LIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFR 1456
++F + FT + + F +G+ + + F E L+ R R
Sbjct: 728 IVFSGIIGVFTRDDDPKTKQQNCNLFSLFFLVMGMICFVTYFFQGFTFGKAGEILTKRLR 787
Query: 1455 VQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXX 1276
F+++L QD S+FD+ ++ G L TRLASDA N+K + +R+ +
Sbjct: 788 YMVFKSMLRQDISWFDDHRNSTGALTTRLASDAANVKGAMSSRLAGITQNVANLGTGIII 847
Query: 1275 XXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQN----DDAGRIAIEIIENVKT 1108
+Y WQ +++ ++ +++ + +++ + +G+IA E IEN +T
Sbjct: 848 SLVYGWQ---LTLLLVVIAPLIILSGMMEMKVLSGQALKDKKELEVSGKIATEAIENFRT 904
Query: 1107 IQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQ 928
+ LTR + F + Y S + R+ LKK + I +S TQ+ MYF + G ++
Sbjct: 905 VVSLTREQKFENMYAQSLQIPYRNALKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVAH 964
Query: 927 GDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDL-MEGD 751
+ ++ A++ GA+A N++ + P++ KAK +A + I+ + P G
Sbjct: 965 QIMTFENVMLVFSAVVFGAIAAGNASSFAPDYAKAKVSASHIIRIMEKIPSIDSYSTRGL 1024
Query: 750 RPE-IRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERF 574
+P + GN+ F V F+YP RP P+++GL +GQT+ALVG SG GKST + +LERF
Sbjct: 1025 KPNWLEGNVKFNEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERF 1084
Query: 573 YDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG--LKDVPLEKIN 400
YD G + +DG++I++L++ LR + +V QEP LF +I EN+ G + V ++I
Sbjct: 1085 YDPMAGTVFLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIE 1144
Query: 399 QALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSAL 220
+A + AN ++F+ +LP +T VG+KG QLSGGQKQRIAIARALVR P ILLLDEATSAL
Sbjct: 1145 RAAKEANIHQFIESLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSAL 1204
Query: 219 DSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGR 40
D+ESE+ VQEALD+AREGRTCI IAHRLS+IQN+DLIV I GKV+E G H QL+ QKG
Sbjct: 1205 DTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGI 1264
Query: 39 YYKLIK 22
Y+ +++
Sbjct: 1265 YFSMVQ 1270
Score = 361 bits (927), Expect = 7e-98
Identities = 212/591 (35%), Positives = 331/591 (55%), Gaps = 9/591 (1%)
Frame = -1
Query: 3735 EAQPVSIPGLFRYG----KKFDYLLLFIGTICAIISGVSQPILALV-SGRVTNALLVYPP 3571
EAQ +P + +G ++ L +G +CA+I+G QP+ ++V SG + P
Sbjct: 684 EAQDEDVPLVSFWGILKLNITEWPYLVVGVLCAVINGCMQPVFSIVFSGIIGVFTRDDDP 743
Query: 3570 TSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGW 3391
+KQ N FL +G+ +T F Q F + ++R+ S+LRQ+ W
Sbjct: 744 KTKQ--QNCNLFSLFFLVMGMICFVTYFFQGFTFGKAGEILTKRLRYMVFKSMLRQDISW 801
Query: 3390 FD--KNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLG 3217
FD +N +G +TT+L ++ + +L + + A L I+++ +Y W+L +++
Sbjct: 802 FDDHRNSTGALTTRLASDAANVKGAMSSRLAGITQNVANLGTGIIISLVYGWQLTLLLVV 861
Query: 3216 VAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAE 3037
+AP + + + ++ +K+ + +G IA E++ RTV + +++ Y
Sbjct: 862 IAPLIILSGMMEMKVLSGQALKDKKELEVSGKIATEAIENFRTVVSLTREQKFENMYAQS 921
Query: 3036 LEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSML 2857
L+ + A+ K +GAYL+ I+T +V +V +++
Sbjct: 922 LQIPYRNALKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVAHQIMTFE-NVMLVFSAVV 980
Query: 2856 LGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHF 2677
GA G S A+VSA+ I + ++++P ID YS G + + G VKF V F
Sbjct: 981 FGAIAAGNASSFAPDYAKAKVSASHIIRIMEKIPSIDSYSTRGLKPNWLEGNVKFNEVVF 1040
Query: 2676 RYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVR 2497
YP+R D +L GL+L V+ G ++ALVG SGCGKST V LL R Y+P AG V +DG +++
Sbjct: 1041 NYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEIK 1100
Query: 2496 ELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGS--TRETMIEVCKMANAHDFIEKMP 2323
+LN++WLR +GIV QEPILF+ +I N+ G+ +++ + K AN H FIE +P
Sbjct: 1101 QLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIERAAKEANIHQFIESLP 1160
Query: 2322 KGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNAS 2143
Y+T +GD G QLSGGQKQR+AIAR L+R P +LLLDEATSALD +SE +VQ AL+ A
Sbjct: 1161 DKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAR 1220
Query: 2142 KGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKA 1990
+GRT I+IAHRLSTI+ AD IV + G + E G H++L+ G YF +V+A
Sbjct: 1221 EGRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVQA 1271
Score = 322 bits (824), Expect = 6e-86
Identities = 207/587 (35%), Positives = 302/587 (51%), Gaps = 26/587 (4%)
Frame = -1
Query: 1698 LYMFLGTVFALIRGLELPALALIFGWVFEGFTFVP------------------YGGRMMH 1573
LYM LGT+ A++ G LP L L+FG + + FT G +
Sbjct: 49 LYMVLGTLAAVLHGTSLPLLMLVFGNMTDSFTKAETSIWPNMTNQSEINNTEVISGSLEE 108
Query: 1572 RMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHA 1393
MA + +G GV + + + + R + F ++ Q+ +FD H
Sbjct: 109 DMATYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQINKIRQKFFHAIMNQEIGWFD--VHD 166
Query: 1392 PGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAF 1213
G+L TRL D I + ++ I W+
Sbjct: 167 IGELNTRLTDDVSKINDGIGDKIGMFFQSIATFLAAFIVGFISGWKLTLVILAVSP---- 222
Query: 1212 VMIGLAYKI------SLMNVEQIQNDDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSK 1051
+IGL+ + S N E AG +A E++ ++T+ + Y + +
Sbjct: 223 -LIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRTVIAFGGQNKELERYNKNLE 281
Query: 1050 QQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGA 871
+ K +KK + I+ + +Y + G ++ + S +++ G
Sbjct: 282 EAKNVGIKKAVTANISIGIAYLLVYASYALAFWYGTSLVLSNEYSVGQVLTVFFSILFGT 341
Query: 870 VAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLM-EGDRPE-IRGNILFENVKFSYP 697
++ + A F A+ AA +F II +P +G +P+ + GN+ F+NV FSYP
Sbjct: 342 FSIGHIAPNIEVFANARGAAYEIFKIIDNEPSIDSFSTQGHKPDSVMGNLEFKNVHFSYP 401
Query: 696 QRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLS 517
R I+KGL GQTVALVG SG GKST + +L+R YD T G + IDGQDIR ++
Sbjct: 402 SRSGIKILKGLNLKVQSGQTVALVGKSGCGKSTTVQLLQRLYDPTEGVVSIDGQDIRTIN 461
Query: 516 LFHLRTQMALVGQEPRLFAGTIRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDT 337
+ +LR + +V QEP LFA TI EN+ G ++V +++I +A++ ANA F+ LP DT
Sbjct: 462 VRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDT 521
Query: 336 DVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTC 157
VGE+G QLSGGQKQRIAIARALVR+PKILLLDEATSALD+ESE VQ ALD+AREGRT
Sbjct: 522 LVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTT 581
Query: 156 ITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQ 16
I IAHRLS+++N+D+I D G + E GNH +LM +KG Y +L+ Q
Sbjct: 582 IVIAHRLSTVRNADVIAGFDGGVIVEQGNHEELMKEKGIYCRLVMMQ 628
>gi|833699|gb|AAA75000.1| multidrug resistance protein
gi|1098061|prf||2115220A P-glycoprotein
Length = 1287
Score = 807 bits (2085), Expect = 0.0
Identities = 466/1255 (37%), Positives = 707/1255 (56%), Gaps = 19/1255 (1%)
Frame = -1
Query: 3723 VSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPT-------- 3568
V + +FRY D +L+ GTI ++ G + P++ LV G +T++ +
Sbjct: 49 VGVFTMFRYSSTSDKMLMLFGTIASLAHGAALPLMMLVFGEMTDSFVNVGQVDTGNFTWE 108
Query: 3567 -----SKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQ 3403
S++ + + Y + G+G + + +IQ + R + ++R F ++VLRQ
Sbjct: 109 SMINASRELQGQMTTYAYYYSGLGFGVMLCAYIQISFWTLSAGRQIKKIRSNFFHAVLRQ 168
Query: 3402 NAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMM 3223
GWFD N +G + T+L D + +I EGIGDK+ +LL+ L+ ++ +I W+L +M
Sbjct: 169 EIGWFDINDAGELNTRLTDDVSKINEGIGDKIAMLLQSLTTLVTGFIIGFIKGWKLTWVM 228
Query: 3222 LGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYE 3043
++P + ++ A+ +++ T KEL KAG++AEE L +RTV AF GQ + + RYE
Sbjct: 229 GAISPIMGLSAAIWAKVLSAFTNKELKAYAKAGAVAEEVLSSIRTVFAFGGQNKEIHRYE 288
Query: 3042 AELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMS 2863
LE +K + K YG L+ G T G V V +
Sbjct: 289 KNLEDAKKIGIKKAITANVSIGFAFLMIYAAYSLAFWYGTTLIIDGGYTI-GSVLTVFFA 347
Query: 2862 MLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENV 2683
+++GA+ +G SP++ NAR +A +I+ ID PKID +SK G + + G ++F+NV
Sbjct: 348 VIIGAFAVGQTSPNIEAFANARGAAYTIFNIIDNQPKIDSFSKEGLKPDKIKGDIEFKNV 407
Query: 2682 HFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTD 2503
F YPSRKD ++L GLNL + G +VALVG SGCGKST+V L+ R Y+PE G +T+DG D
Sbjct: 408 IFTYPSRKDIQVLKGLNLNIPSGKTVALVGSSGCGKSTTVQLIQRFYDPEDGVITLDGQD 467
Query: 2502 VRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMP 2323
+R LNI +LR +G+V QEPILF+ TI +N+ G T+E + K ANA+DFI K+P
Sbjct: 468 IRSLNIRYLREIIGVVSQEPILFDTTIADNIRYGREDVTKEEIERATKEANAYDFIMKLP 527
Query: 2322 KGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNAS 2143
+TL+G+ G QLSGGQKQR+AIAR L+R+PK+LLLDEATSALD +SE++VQSAL+ A
Sbjct: 528 DKLETLVGERGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQSALDKAR 587
Query: 2142 KGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKADPXX 1963
+GRTTI++AHRLSTIR A+ I F+ GVIVE G+H+EL+ GG YF+LV Q +
Sbjct: 588 EGRTTIVVAHRLSTIRNANAIAGFDNGVIVEQGSHKELMERGGVYFNLVTLQTVETSKDT 647
Query: 1962 XXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXXXXXXX 1783
+D S RR +S N S +
Sbjct: 648 E----------EDLETHIYEKKIPVTHTHSNLVRRKSSRNTIKSKVPET-------EDKE 690
Query: 1782 XXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFT 1603
E+G + + K K + Y +G + A+I G PA A+IF +
Sbjct: 691 VDEEEKKKEEGPPPVSFFKVMKLNKPEWPYFVVGVICAMINGATQPAFAIIFSRIIG--V 748
Query: 1602 FVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQD 1423
F +M +M + F ++G + + F E L+MR R+ SF+++L Q+
Sbjct: 749 FAGPVSQMRSESSMYSLLFLALGGVSFITFFLQGFTFGKAGEILTMRLRLGSFKSMLRQE 808
Query: 1422 ASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXX 1243
+FD+ ++ G L TRLA+DA ++ R+ + IY WQ
Sbjct: 809 IGWFDDSKNSTGALTTRLATDASQVQGATGTRLALLAQNVANLGTAIIISFIYGWQLTLL 868
Query: 1242 XXXXXXXLAFV-MIGLAYKISLMNVEQIQNDDAGRIAIEIIENVKTIQLLTRCELFFDHY 1066
+A ++ + ++ + + AG+I+ + + N++T+ LTR F Y
Sbjct: 869 ILAIVPVIAAAGLVEMKMFAGHAKKDKKELEKAGKISTDAVLNIRTVVSLTRERKFEAMY 928
Query: 1065 QTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAV-GIRIIYQGDKSSDDTFKGII 889
+ S + R+ +KK + + Y L+Q+ +C+ ++V G ++ +G D+ F
Sbjct: 929 EKSLEGPYRNSIKKAHLHGLTYGLSQAHHVLCLCWVFSVLGAYLVVEGLMKLDEVFLVSS 988
Query: 888 AMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLM-EGDRPE-IRGNILFEN 715
A++LGA+A+ ++ + P++ KA +A +F+++ R P+ +G++P+ GN++F+
Sbjct: 989 AIVLGAMALGQTSSFAPDYTKAMISAAHIFSLLERVPQIDSYSDQGEKPKNCSGNVVFKG 1048
Query: 714 VKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQ 535
V F+YP RP +++GL + +G+T+ALVG SG GKST + +LERFYD G + +DG
Sbjct: 1049 VNFNYPTRPDITVLQGLDISVKQGETLALVGSSGCGKSTTVSLLERFYDPFEGEVLVDGL 1108
Query: 534 DIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG--LKDVPLEKINQALELANANRFLA 361
+R L++ +R QM +V QEP LF +I +N+ G + V E+I A + AN + F+
Sbjct: 1109 SVRNLNIQWVRAQMGIVSQEPILFDCSIGDNIAYGDNNRKVTQEEIETAAKEANIHSFIE 1168
Query: 360 NLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALD 181
+L +T VG+KG QLSGGQKQRIAIARAL+R PKILLLDEATSALD+ESE+ VQEALD
Sbjct: 1169 SLTDKYNTRVGDKGTQLSGGQKQRIAIARALIRKPKILLLDEATSALDTESEKVVQEALD 1228
Query: 180 RAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQ 16
+AR GRTCI IAHRLS+IQN+D I I GKV E G H QL+ KG Y+ L+ Q
Sbjct: 1229 KARMGRTCIVIAHRLSTIQNADKIAVIQNGKVVEQGTHQQLLQLKGVYFSLVTIQ 1283
Score = 394 bits (1013), Expect = e-108
Identities = 229/586 (39%), Positives = 340/586 (57%), Gaps = 6/586 (1%)
Frame = -1
Query: 3726 PVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNK 3547
PVS + + K ++ +G ICA+I+G +QP A++ R+ V+ Q R++
Sbjct: 704 PVSFFKVMKLNKP-EWPYFVVGVICAMINGATQPAFAIIFSRIIG---VFAGPVSQMRSE 759
Query: 3546 ANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFD--KNHS 3373
++ +FL +G IT F+Q F + ++R S+LRQ GWFD KN +
Sbjct: 760 SSMYSLLFLALGGVSFITFFLQGFTFGKAGEILTMRLRLGSFKSMLRQEIGWFDDSKNST 819
Query: 3372 GTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCIC 3193
G +TT+L +++ G +L +L + A L AI++++IY W+L ++L + P
Sbjct: 820 GALTTRLATDASQVQGATGTRLALLAQNVANLGTAIIISFIYGWQLTLLILAIVPVIAAA 879
Query: 3192 MSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFA 3013
+ + K+ + KAG I+ ++++ +RTV + + + YE LE + +
Sbjct: 880 GLVEMKMFAGHAKKDKKELEKAGKISTDAVLNIRTVVSLTRERKFEAMYEKSLEGPYRNS 939
Query: 3012 VWKXXXXXXXXXXXXXXXXXXXGCGM--LYGAYLLKVGIITTPGDVFIVVMSMLLGAYFL 2839
+ K C + + GAYL+ G++ +VF+V +++LGA L
Sbjct: 940 I-KKAHLHGLTYGLSQAHHVLCLCWVFSVLGAYLVVEGLMKLD-EVFLVSSAIVLGAMAL 997
Query: 2838 GLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRK 2659
G S A +SAA I+ ++RVP+ID YS G++ +N G V F+ V+F YP+R
Sbjct: 998 GQTSSFAPDYTKAMISAAHIFSLLERVPQIDSYSDQGEKPKNCSGNVVFKGVNFNYPTRP 1057
Query: 2658 DAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEW 2479
D +L GL++ V+ G ++ALVG SGCGKST+V LL R Y+P G V +DG VR LNI+W
Sbjct: 1058 DITVLQGLDISVKQGETLALVGSSGCGKSTTVSLLERFYDPFEGEVLVDGLSVRNLNIQW 1117
Query: 2478 LRNTVGIVQQEPILFNDTIHNNLLIG--NPGSTRETMIEVCKMANAHDFIEKMPKGYDTL 2305
+R +GIV QEPILF+ +I +N+ G N T+E + K AN H FIE + Y+T
Sbjct: 1118 VRAQMGIVSQEPILFDCSIGDNIAYGDNNRKVTQEEIETAAKEANIHSFIESLTDKYNTR 1177
Query: 2304 IGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTI 2125
+GD G QLSGGQKQR+AIAR LIR PK+LLLDEATSALD +SE +VQ AL+ A GRT I
Sbjct: 1178 VGDKGTQLSGGQKQRIAIARALIRKPKILLLDEATSALDTESEKVVQEALDKARMGRTCI 1237
Query: 2124 MIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQ 1987
+IAHRLSTI+ ADKI + G +VE G H++L++L G YF LV Q
Sbjct: 1238 VIAHRLSTIQNADKIAVIQNGKVVEQGTHQQLLQLKGVYFSLVTIQ 1283
>gi|1362689|pir||S55692 multidrug resistance protein homolog (mdr) -
African clawed frog
Length = 1287
Score = 807 bits (2084), Expect = 0.0
Identities = 466/1255 (37%), Positives = 707/1255 (56%), Gaps = 19/1255 (1%)
Frame = -1
Query: 3723 VSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPT-------- 3568
V + +FRY D +L+ GTI ++ G + P++ LV G +T++ +
Sbjct: 49 VGVFTMFRYSSTSDKMLMLFGTIASLAHGAALPLMMLVFGEMTDSFVNVGQVDTGNFTWE 108
Query: 3567 -----SKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQ 3403
S++ + + Y + G+G + + +IQ + R + ++R F ++VLRQ
Sbjct: 109 SMINASRELQGQMTTYAYYYSGLGFGVMLCAYIQISFWTLSAGRQIKKIRSNFFHAVLRQ 168
Query: 3402 NAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMM 3223
GWFD N +G + T+L D + +I EGIGDK+ +LL+ L+ ++ +I W+L +M
Sbjct: 169 EIGWFDINDAGELNTRLTDDVSKINEGIGDKIAMLLQSLTTLVTGFIIGFIKGWKLTWVM 228
Query: 3222 LGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYE 3043
++P + ++ A+ +++ T KEL KAG++AEE L +RTV AF GQ + + RYE
Sbjct: 229 GAISPIMGLSAAIWAKVLSAFTNKELKAYAKAGAVAEEVLSSIRTVFAFGGQNKEIHRYE 288
Query: 3042 AELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMS 2863
LE +K + K YG L+ G T G V V +
Sbjct: 289 KNLEDAKKIGIKKAITANVSIGFAFLMIYAAYSLAFWYGTTLIIDGGYTI-GSVLTVFFA 347
Query: 2862 MLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENV 2683
+++GA+ +G SP++ NAR +A +I+ ID PKID +SK G + + G ++F+NV
Sbjct: 348 VIIGAFAVGQTSPNIEAFANARGAAYTIFNIIDNQPKIDSFSKEGLKPDKIKGDIEFKNV 407
Query: 2682 HFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTD 2503
F YPSRKD ++L GLNL + G +VALVG SGCGKST+V L+ R Y+PE G +T+DG D
Sbjct: 408 IFTYPSRKDIQVLKGLNLNIPSGKTVALVGSSGCGKSTTVQLIQRFYDPEDGVITLDGQD 467
Query: 2502 VRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMP 2323
+R LNI +LR +G+V QEPILF+ TI +N+ G T+E + K ANA+DFI K+P
Sbjct: 468 IRSLNIRYLREIIGVVSQEPILFDTTIADNIRYGREDVTKEEIERATKEANAYDFIMKLP 527
Query: 2322 KGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNAS 2143
+TL+G+ G QLSGGQKQR+AIAR L+R+PK+LLLDEATSALD +SE++VQSAL+ A
Sbjct: 528 DKLETLVGERGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQSALDKAR 587
Query: 2142 KGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKADPXX 1963
+GRTTI++AHRLSTIR A+ I F+ GVIVE G+H+EL+ GG YF+LV Q +
Sbjct: 588 EGRTTIVVAHRLSTIRNANAIAGFDNGVIVEQGSHKELMERGGVYFNLVTLQTVETSKDT 647
Query: 1962 XXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXXXXXXX 1783
+D S RR +S N S +
Sbjct: 648 E----------EDLETHIYEKKIPVTHTHSNLVRRKSSRNTIKSKVPET-------EDKE 690
Query: 1782 XXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFT 1603
E+G + + K K + Y +G + A+I G PA A+IF +
Sbjct: 691 VDEEEKKKEEGPPPVSFFKVMKLNKPEWPYFVVGVICAMINGATQPAFAIIFSRIIG--V 748
Query: 1602 FVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQD 1423
F +M +M + F ++G + + F E L+MR R+ SF+++L Q+
Sbjct: 749 FAGPVSQMRSESSMYSLLFLALGGVSFITFFLQRFTFGKAGEILTMRLRLGSFKSMLRQE 808
Query: 1422 ASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXX 1243
+FD+ ++ G L TRLA+DA ++ R+ + IY WQ
Sbjct: 809 IGWFDDSKNSTGALTTRLATDASQVQGATGTRLALLAQNVANLGTAIIISFIYGWQLTLL 868
Query: 1242 XXXXXXXLAFV-MIGLAYKISLMNVEQIQNDDAGRIAIEIIENVKTIQLLTRCELFFDHY 1066
+A ++ + ++ + + AG+I+ + + N++T+ LTR F Y
Sbjct: 869 ILAIVPVIAAAGLVEMKMFAGHAKKDKKELEKAGKISTDAVLNIRTVVSLTRERKFEAMY 928
Query: 1065 QTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAV-GIRIIYQGDKSSDDTFKGII 889
+ S + R+ +KK + + Y L+Q+ +C+ ++V G ++ +G D+ F
Sbjct: 929 EKSLEGPYRNSIKKAHLHGLTYGLSQAHHVLCLCWVFSVLGAYLVVEGLMKLDEVFLVSS 988
Query: 888 AMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLM-EGDRPE-IRGNILFEN 715
A++LGA+A+ ++ + P++ KA +A +F+++ R P+ +G++P+ GN++F+
Sbjct: 989 AIVLGAMALGQTSSFAPDYTKAMISAAHIFSLLERVPQIDSYSDQGEKPKNCSGNVVFKG 1048
Query: 714 VKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQ 535
V F+YP RP +++GL + +G+T+ALVG SG GKST + +LERFYD G + +DG
Sbjct: 1049 VNFNYPTRPDITVLQGLDISVKQGETLALVGSSGCGKSTTVSLLERFYDPFEGEVLVDGL 1108
Query: 534 DIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG--LKDVPLEKINQALELANANRFLA 361
+R L++ +R QM +V QEP LF +I +N+ G + V E+I A + AN + F+
Sbjct: 1109 SVRNLNIQWVRAQMGIVSQEPILFDCSIGDNIAYGDNNRKVTQEEIETAAKEANIHSFIE 1168
Query: 360 NLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALD 181
+L +T VG+KG QLSGGQKQRIAIARAL+R PKILLLDEATSALD+ESE+ VQEALD
Sbjct: 1169 SLTDKYNTRVGDKGTQLSGGQKQRIAIARALIRKPKILLLDEATSALDTESEKVVQEALD 1228
Query: 180 RAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQ 16
+AR GRTCI IAHRLS+IQN+D I I GKV E G H QL+ KG Y+ L+ Q
Sbjct: 1229 KARMGRTCIVIAHRLSTIQNADKIAVIQNGKVVEQGTHQQLLQLKGVYFSLVTIQ 1283
Score = 395 bits (1014), Expect = e-108
Identities = 229/586 (39%), Positives = 340/586 (57%), Gaps = 6/586 (1%)
Frame = -1
Query: 3726 PVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNK 3547
PVS + + K ++ +G ICA+I+G +QP A++ R+ V+ Q R++
Sbjct: 704 PVSFFKVMKLNKP-EWPYFVVGVICAMINGATQPAFAIIFSRIIG---VFAGPVSQMRSE 759
Query: 3546 ANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFD--KNHS 3373
++ +FL +G IT F+Q F + ++R S+LRQ GWFD KN +
Sbjct: 760 SSMYSLLFLALGGVSFITFFLQRFTFGKAGEILTMRLRLGSFKSMLRQEIGWFDDSKNST 819
Query: 3372 GTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCIC 3193
G +TT+L +++ G +L +L + A L AI++++IY W+L ++L + P
Sbjct: 820 GALTTRLATDASQVQGATGTRLALLAQNVANLGTAIIISFIYGWQLTLLILAIVPVIAAA 879
Query: 3192 MSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFA 3013
+ + K+ + KAG I+ ++++ +RTV + + + YE LE + +
Sbjct: 880 GLVEMKMFAGHAKKDKKELEKAGKISTDAVLNIRTVVSLTRERKFEAMYEKSLEGPYRNS 939
Query: 3012 VWKXXXXXXXXXXXXXXXXXXXGCGM--LYGAYLLKVGIITTPGDVFIVVMSMLLGAYFL 2839
+ K C + + GAYL+ G++ +VF+V +++LGA L
Sbjct: 940 I-KKAHLHGLTYGLSQAHHVLCLCWVFSVLGAYLVVEGLMKLD-EVFLVSSAIVLGAMAL 997
Query: 2838 GLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRK 2659
G S A +SAA I+ ++RVP+ID YS G++ +N G V F+ V+F YP+R
Sbjct: 998 GQTSSFAPDYTKAMISAAHIFSLLERVPQIDSYSDQGEKPKNCSGNVVFKGVNFNYPTRP 1057
Query: 2658 DAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEW 2479
D +L GL++ V+ G ++ALVG SGCGKST+V LL R Y+P G V +DG VR LNI+W
Sbjct: 1058 DITVLQGLDISVKQGETLALVGSSGCGKSTTVSLLERFYDPFEGEVLVDGLSVRNLNIQW 1117
Query: 2478 LRNTVGIVQQEPILFNDTIHNNLLIG--NPGSTRETMIEVCKMANAHDFIEKMPKGYDTL 2305
+R +GIV QEPILF+ +I +N+ G N T+E + K AN H FIE + Y+T
Sbjct: 1118 VRAQMGIVSQEPILFDCSIGDNIAYGDNNRKVTQEEIETAAKEANIHSFIESLTDKYNTR 1177
Query: 2304 IGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTI 2125
+GD G QLSGGQKQR+AIAR LIR PK+LLLDEATSALD +SE +VQ AL+ A GRT I
Sbjct: 1178 VGDKGTQLSGGQKQRIAIARALIRKPKILLLDEATSALDTESEKVVQEALDKARMGRTCI 1237
Query: 2124 MIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQ 1987
+IAHRLSTI+ ADKI + G +VE G H++L++L G YF LV Q
Sbjct: 1238 VIAHRLSTIQNADKIAVIQNGKVVEQGTHQQLLQLKGVYFSLVTIQ 1283
>gi|50732589|ref|XP_418707.1| PREDICTED: similar to ATP-binding
cassette, sub-family B (MDR/TAP), member 1A; multiple
drug resistant 1a [Gallus gallus]
Length = 1734
Score = 806 bits (2081), Expect = 0.0
Identities = 484/1274 (37%), Positives = 697/1274 (53%), Gaps = 38/1274 (2%)
Frame = -1
Query: 3735 EAQPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQF 3556
E + V + LFRY D LL+ +G I A +G P++ ++ G +TNA ++ S
Sbjct: 105 EKKVVGVIELFRYADWVDILLMVVGLIAAAANGTGLPLMIIIFGDMTNAFVLSGVNSSTS 164
Query: 3555 RNKANEN------------------VYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRH 3430
+ N Y ++GIG + I + IQ F TR +++R
Sbjct: 165 EGASVNNSSCQPAPGVDIEADMTKFAYYYVGIGFAVLILSTIQVWTFLIAATRQTSRIRR 224
Query: 3429 RFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYI 3250
+F ++VL Q WFD GT+ T+L D + I EGIGDK+ + ++ F+ +A I + +
Sbjct: 225 KFFFAVLHQEMAWFDSTQIGTLNTRLTDDINTIHEGIGDKICIFVQFFSTFLAGITIGFA 284
Query: 3249 YEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNG 3070
+ W+L ++L V+P ++ + + S T KEL KAG++AEE L +RTV AFNG
Sbjct: 285 HGWKLTLVILSVSPLLAASAAVWSTLLASLTAKELSAYAKAGAVAEEVLTAIRTVVAFNG 344
Query: 3069 QEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTP 2890
Q++ + +Y+ LE R V K YG L + P
Sbjct: 345 QQKALAKYDTNLEAARHVGVKKSITTNTSLGVSQFLIFGSYALAFWYGTKLT----VEEP 400
Query: 2889 -----GDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGK 2725
G V IV S+L+GA+ LG +P++ + NAR +A +YQ I++ ID SK G
Sbjct: 401 ENYDIGRVLIVFFSVLIGAFSLGQAAPNLESVANARGAAYEVYQIINKKRLIDSSSKEGY 460
Query: 2724 RLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRL 2545
+ + G ++F N+HF YPSR D IL GLNL V+ G ++ALVG SGCGKST+V LL R
Sbjct: 461 KPDKLKGEIEFRNIHFSYPSRPDITILKGLNLKVQTGKTIALVGASGCGKSTTVQLLQRF 520
Query: 2544 YEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEV 2365
Y+P+ G VT+DG D+R LN++WLR +GIV QEP+LF TI N+ G + + +
Sbjct: 521 YDPDQGEVTLDGRDIRTLNVKWLRENIGIVSQEPVLFATTIAENIRYGREDISDAEIEQA 580
Query: 2364 CKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDA 2185
K ANA DFI ++P ++T++G+ G QLSGGQKQR+AIAR L R+PK+LLLDEATSALD
Sbjct: 581 AKEANAFDFISRLPDKFNTMVGERGAQLSGGQKQRIAIARALARNPKILLLDEATSALDT 640
Query: 2184 QSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYF 2005
QSES+VQ+AL+ A GRTTI+IAHRLSTIR AD I FEKG++VE G H EL+ G Y+
Sbjct: 641 QSESVVQAALDKARTGRTTIVIAHRLSTIRTADTIAAFEKGIVVEQGTHSELMLQKGVYY 700
Query: 2004 DLVKAQ----QFKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNS---L 1846
LV Q + D + ++ E G
Sbjct: 701 SLVMQQSGSNNVQDDGTSEEDEETEAEEYEENDKSSSVEKLNLKDHFEEPVITGRGSIRR 760
Query: 1845 NDSFSGSKRSXXXXXXXXXXXXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFAL 1666
S SKRS E+ Y I K +LY+ LG + A
Sbjct: 761 RSSRYKSKRS----SSKKKSSKKKKKELEEENLPAVPYTRILALNKPEWLYVLLGVIAAA 816
Query: 1665 IRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAV 1486
+ G PA A+IFG + F R + + ++++ F +GV + + +F
Sbjct: 817 VSGGVHPAFAVIFGKIIGAFQERDPERRNKNTLVLSLM-FLLLGVITLATYIIQGFMFGK 875
Query: 1485 VSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXX 1306
E L+MR R SF+ LL Q+ ++D+ +A G L+TRLA+DA +K +R+ +
Sbjct: 876 SGEILTMRLRSLSFKALLQQEIGWYDDQKNAVGVLLTRLATDASQVKGATGSRLGLMTMT 935
Query: 1305 XXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMN----VEQIQNDDAGRI 1138
+Y WQ + FV+ A +S ++ +Q ++AGR+
Sbjct: 936 VFTLLTAIIIAFVYGWQ---LTLLILACIPFVIAANAANVSSVSGHAAKDQKALEEAGRV 992
Query: 1137 AIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFT 958
+ E +EN++T+ LTR E F++ Y S R LKK + Y + QS YF+
Sbjct: 993 STESVENIRTVASLTREEAFYEKYINSLNGPYRDSLKKAPLYGFTYGIAQSANYFVNAAV 1052
Query: 957 YAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKP 778
+ G +I + + ++ F +++ A+ V SA P++ KAK +A +F+++ RKP
Sbjct: 1053 FRFGAWLIARCLTNFENVFIVFSSVIFAAMNVGQSASLAPDYGKAKVSAQRIFHLLDRKP 1112
Query: 777 RTGDLM-EGDR-PEIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGK 604
+ EG++ GNI F N+ F YP RP +++GL +GQT+ALVG SG GK
Sbjct: 1113 QIDSYSEEGEKLSNFEGNIEFRNIHFVYPTRPEVQVLQGLNVKVNKGQTLALVGSSGCGK 1172
Query: 603 STNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGLK 424
ST+I +LERFYD G + DG D + L L LR+++ LV QEP LF +I EN+ G
Sbjct: 1173 STSIQLLERFYDPVEGQVLADGFDTKSLHLQWLRSRLGLVSQEPILFDCSIAENIQYGDN 1232
Query: 423 D--VPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKI 250
+ V E+I +A + AN + F+ LP +T VGEKG QLSGGQKQRIAIARALVR+P +
Sbjct: 1233 NRLVSQEEIEEAAKAANIHAFIDKLPEKYNTRVGEKGTQLSGGQKQRIAIARALVRNPAV 1292
Query: 249 LLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGN 70
LLLDEATSALD+ESE+ VQ+ALD AR+GRTCI IAHRL++IQN+D+I I G+V E G
Sbjct: 1293 LLLDEATSALDTESEKIVQKALDNARQGRTCIVIAHRLTTIQNADIIAVIQNGRVVEQGT 1352
Query: 69 HTQLMHQKGRYYKL 28
H+QL+ ++G YY L
Sbjct: 1353 HSQLLAKEGHYYAL 1366
Score = 295 bits (756), Expect = 5e-78
Identities = 203/599 (33%), Positives = 310/599 (50%), Gaps = 25/599 (4%)
Frame = -1
Query: 1737 GYLDIFKNAKG-NYLYMFLGTVFALIRGLELPALALIFG-----WVFEGFTFVPYGGRMM 1576
G +++F+ A + L M +G + A G LP + +IFG +V G G +
Sbjct: 110 GVIELFRYADWVDILLMVVGLIAAAANGTGLPLMIIIFGDMTNAFVLSGVNSSTSEGASV 169
Query: 1575 HRMAMA----------VIAFASVGVGVWFSQLASSVL----FAVVSENLSMRFRVQSFRN 1438
+ + + FA VG+ F+ L S + F + + + R R + F
Sbjct: 170 NNSSCQPAPGVDIEADMTKFAYYYVGIGFAVLILSTIQVWTFLIAATRQTSRIRRKFFFA 229
Query: 1437 LLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCW 1258
+L+Q+ ++FD+ G L TRL D I + ++ + W
Sbjct: 230 VLHQEMAWFDSTQI--GTLNTRLTDDINTIHEGIGDKICIFVQFFSTFLAGITIGFAHGW 287
Query: 1257 QXXXXXXXXX-XXLAFVMIGLAYKISLMNVEQIQNDDAGRIAIEIIENVKTIQLLTRCEL 1081
+ A + SL E AG +A E++ ++T+ +
Sbjct: 288 KLTLVILSVSPLLAASAAVWSTLLASLTAKELSAYAKAGAVAEEVLTAIRTVVAFNGQQK 347
Query: 1080 FFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTF 901
Y T+ + + +KK + + ++Q ++ + G ++ + ++ D
Sbjct: 348 ALAKYDTNLEAARHVGVKKSITTNTSLGVSQFLIFGSYALAFWYGTKLTVEEPENYDIGR 407
Query: 900 KGII--AMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRT-GDLMEGDRPE-IRG 733
I+ ++++GA ++ +A A+ AA ++ II +K EG +P+ ++G
Sbjct: 408 VLIVFFSVLIGAFSLGQAAPNLESVANARGAAYEVYQIINKKRLIDSSSKEGYKPDKLKG 467
Query: 732 NILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGA 553
I F N+ FSYP RP I+KGL G+T+ALVG SG GKST + +L+RFYD G
Sbjct: 468 EIEFRNIHFSYPSRPDITILKGLNLKVQTGKTIALVGASGCGKSTTVQLLQRFYDPDQGE 527
Query: 552 LRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGLKDVPLEKINQALELANAN 373
+ +DG+DIR L++ LR + +V QEP LFA TI EN+ G +D+ +I QA + ANA
Sbjct: 528 VTLDGRDIRTLNVKWLRENIGIVSQEPVLFATTIAENIRYGREDISDAEIEQAAKEANAF 587
Query: 372 RFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQ 193
F++ LP +T VGE+G QLSGGQKQRIAIARAL R+PKILLLDEATSALD++SE VQ
Sbjct: 588 DFISRLPDKFNTMVGERGAQLSGGQKQRIAIARALARNPKILLLDEATSALDTQSESVVQ 647
Query: 192 EALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQ 16
ALD+AR GRT I IAHRLS+I+ +D I +KG V E G H++LM QKG YY L+ +Q
Sbjct: 648 AALDKARTGRTTIVIAHRLSTIRTADTIAAFEKGIVVEQGTHSELMLQKGVYYSLVMQQ 706
>gi|25297453|pir||D87789 protein C34G6.4 [imported] - Caenorhabditis
elegans
Length = 1289
Score = 806 bits (2081), Expect = 0.0
Identities = 462/1259 (36%), Positives = 702/1259 (55%), Gaps = 27/1259 (2%)
Frame = -1
Query: 3711 GLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALL----------------- 3583
G+F Y + D LLL GT+ A+I G P+LA+V G +T L
Sbjct: 37 GIFYYTQGVDLLLLITGTVAAVIHGAGFPLLAIVLGGMTTVFLRAQNSDFVVGVDNVNPE 96
Query: 3582 -VYPPTSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLR 3406
+ P + +F ++ + +L +G+ + T+++Q CF+ R++ ++R ++ ++LR
Sbjct: 97 GLVPISLDEFNSEVVKYCIYYLVLGVLMFFTSYVQIACFESYAERLVHKLRQNYLKAILR 156
Query: 3405 QNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASM 3226
Q WFDK +G +T +L D +ER+REG+GDK +L++ FA +A V + Y W + +
Sbjct: 157 QQIQWFDKQQTGNLTARLTDDLERVREGLGDKFALLVQMFAAFLAGYGVGFFYSWSMTLV 216
Query: 3225 MLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRY 3046
M+G AP + + +++ M + T E AG+IAEE+ +RTV + NG + + R+
Sbjct: 217 MMGFAPLIVLSGAKMSKSMATRTRVEQETYAVAGAIAEETFSSIRTVHSLNGHKRELDRF 276
Query: 3045 EAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVM 2866
LE GR+ + K YG+ L+ G +F V
Sbjct: 277 YNALEVGRQTGIVKYCYMGIGVGFSNLCMYSSYALAFWYGSTLIINDPTFDRGLIFTVFF 336
Query: 2865 SMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFEN 2686
++L G+ LG PH+ AR +A+++ + I+ PKIDPYS G + N+ G + F++
Sbjct: 337 AVLSGSTSLGGALPHLASFGTARGAASTVLRVINSHPKIDPYSLEGILVDNMKGDISFKD 396
Query: 2685 VHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGT 2506
VHFRYPSRKD +L G++L ++ G +ALVG SGCGKST V LL R Y+P G V IDG
Sbjct: 397 VHFRYPSRKDIHVLKGISLELKAGDKIALVGSSGCGKSTIVNLLQRFYDPTKGRVLIDGV 456
Query: 2505 DVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKM 2326
D+RE+N+ LR +GIV QEP+LF+ TI+ N+ +GN +T + ++E CKMANA+DFI+++
Sbjct: 457 DLREVNVHSLREQIGIVSQEPVLFDGTIYENIKMGNEHATHDQVVEACKMANANDFIKRL 516
Query: 2325 PKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNA 2146
P GY T +G+ GVQLSGGQKQR+AIAR L+++PK+LLLDEATSALD ++E VQ AL+ A
Sbjct: 517 PDGYGTRVGEKGVQLSGGQKQRIAIARALVKNPKILLLDEATSALDTEAEREVQGALDQA 576
Query: 2145 SKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKADPX 1966
GRTTI++AHRLSTIR D+I F+ G IVE+G+HEEL+ G ++D+ +AQ +
Sbjct: 577 QAGRTTIIVAHRLSTIRNVDRIFVFKAGNIVESGSHEELMSKQGIFYDMTQAQVVRQQQQ 636
Query: 1965 XXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXXXXXX 1786
D++DT A S++ +
Sbjct: 637 EAGK------DIEDTISESAHSHLSRKSSTRSAISIATSIHQLAEEVELIDPFNGQTNQD 690
Query: 1785 XXXXXXXXXEDGQITAGYLDIFKNAK--GNYLYMFLGTVF-ALIRGLELPALALIFGWVF 1615
G+ A +FK K G+ + F+G +F A I G P AL++ +F
Sbjct: 691 VIRSRILSAFGGECKAPPTSMFKIFKFNGDKVGWFIGGIFGAFIFGSVTPVFALVYAEIF 750
Query: 1614 EGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNL 1435
++ +M + F +G+ + S+ E+L+M+ R ++F+NL
Sbjct: 751 NVYSLP--ADQMQANVYFWCGMFVLMGITFFVGFFTSANCLGRCGESLTMKLRFEAFKNL 808
Query: 1434 LYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQ 1255
L QD +++D+ H GKL TR A+DAPN++ V R+ V Y WQ
Sbjct: 809 LRQDIAFYDDLRHGTGKLCTRFATDAPNVRYVF-TRLPVVLASIVTICGALGIGFYYGWQ 867
Query: 1254 XXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQN----DDAGRIAIEIIENVKTIQLLTRC 1087
+ +++G +++ + +QI++ ++AG++A + +E+++T+ L R
Sbjct: 868 ---LALILVVMVPLLVMGGYFEMQMRFGKQIRDTQLLEEAGKVASQAVEHIRTVHSLNRQ 924
Query: 1086 ELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDD 907
E F Y ++ + LK ++ +QS ++FM + +G + Q D
Sbjct: 925 EQFHFTYCEYLREPFNTNLKHAHTYGAVFAFSQSLIFFMYAAAFYLGSIFVNQQAMQPID 984
Query: 906 TFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLME-GDRPEIRGN 730
++ A+ + N+ + P+ VKA+ AA +LF +I L + G I GN
Sbjct: 985 VYRVFFAISFCGQMIGNTTSFIPDVVKARLAASLLFYLIEHPTPIDSLSDSGIVKPITGN 1044
Query: 729 ILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGAL 550
I NV F+YP R +++G G+TVALVG SG GKST +G+LERFY+ G +
Sbjct: 1045 ISIRNVFFNYPTRKDTKVLQGFTLDIKAGKTVALVGHSGCGKSTIMGLLERFYNQDKGMI 1104
Query: 549 RIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGL-KDVPLEKINQALELANAN 373
IDG +IR L++ LR Q+ +V QEP LF TI EN+C G ++V ++I +A ++AN +
Sbjct: 1105 MIDGDNIRNLNISSLREQVCIVSQEPTLFDCTIGENICYGTNRNVTYQEIVEAAKMANIH 1164
Query: 372 RFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQ 193
F+ LP G DT VGEKG QLSGGQKQRIAIARALVR P +LLLDEATSALD+ESE+ VQ
Sbjct: 1165 NFILGLPDGYDTHVGEKGTQLSGGQKQRIAIARALVRSPSVLLLDEATSALDTESEKIVQ 1224
Query: 192 EALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQ 16
EALD A++GRTC+ IAHRLS+IQNSD+I + +GK+ E G H +L+ + Y K + Q
Sbjct: 1225 EALDAAKQGRTCLVIAHRLSTIQNSDVIAIVSEGKIVEKGTHDELIRKSEIYQKFCETQ 1283
Score = 318 bits (814), Expect = 9e-85
Identities = 203/594 (34%), Positives = 316/594 (53%), Gaps = 8/594 (1%)
Frame = -1
Query: 3741 QLEAQPVSIPGLFRYGKKFDYLLLFIGTIC-AIISGVSQPILALVSGRVTNALLVYPPTS 3565
+ +A P S+ +F++ D + FIG I A I G P+ ALV + N VY +
Sbjct: 703 ECKAPPTSMFKIFKFNG--DKVGWFIGGIFGAFIFGSVTPVFALVYAEIFN---VYSLPA 757
Query: 3564 KQFRNKANENVYIFLGIGIFISITNFIQYM----CFQHCCTRVMAQMRHRFVYSVLRQNA 3397
Q + NVY + G+ + + IT F+ + C C + ++R ++LRQ+
Sbjct: 758 DQMQ----ANVYFWCGMFVLMGITFFVGFFTSANCLGRCGESLTMKLRFEAFKNLLRQDI 813
Query: 3396 GWFD--KNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMM 3223
++D ++ +G + T+ +R + +L V+L + A+ + + Y W+LA ++
Sbjct: 814 AFYDDLRHGTGKLCTRFATDAPNVRY-VFTRLPVVLASIVTICGALGIGFYYGWQLALIL 872
Query: 3222 LGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYE 3043
+ + P + + I++ + +AG +A +++ +RTV + N QE+ Y
Sbjct: 873 VVMVPLLVMGGYFEMQMRFGKQIRDTQLLEEAGKVASQAVEHIRTVHSLNRQEQFHFTYC 932
Query: 3042 AELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMS 2863
L + + G+ + + P DV+ V +
Sbjct: 933 EYLREPFNTNLKHAHTYGAVFAFSQSLIFFMYAAAFYLGSIFVNQQAMQ-PIDVYRVFFA 991
Query: 2862 MLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENV 2683
+ +G + + ++ AR++A+ ++ I+ ID S +G ++ + G + NV
Sbjct: 992 ISFCGQMIGNTTSFIPDVVKARLAASLLFYLIEHPTPIDSLSDSGI-VKPITGNISIRNV 1050
Query: 2682 HFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTD 2503
F YP+RKD K+L G L ++ G +VALVGHSGCGKST +GLL R Y + G + IDG +
Sbjct: 1051 FFNYPTRKDTKVLQGFTLDIKAGKTVALVGHSGCGKSTIMGLLERFYNQDKGMIMIDGDN 1110
Query: 2502 VRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIG-NPGSTRETMIEVCKMANAHDFIEKM 2326
+R LNI LR V IV QEP LF+ TI N+ G N T + ++E KMAN H+FI +
Sbjct: 1111 IRNLNISSLREQVCIVSQEPTLFDCTIGENICYGTNRNVTYQEIVEAAKMANIHNFILGL 1170
Query: 2325 PKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNA 2146
P GYDT +G+ G QLSGGQKQR+AIAR L+R P VLLLDEATSALD +SE IVQ AL+ A
Sbjct: 1171 PDGYDTHVGEKGTQLSGGQKQRIAIARALVRSPSVLLLDEATSALDTESEKIVQEALDAA 1230
Query: 2145 SKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQ 1984
+GRT ++IAHRLSTI+ +D I +G IVE G H+EL+R Y + Q+
Sbjct: 1231 KQGRTCLVIAHRLSTIQNSDVIAIVSEGKIVEKGTHDELIRKSEIYQKFCETQR 1284
>gi|39595370|emb|CAE60408.1| Hypothetical protein CBG04013
[Caenorhabditis briggsae]
Length = 1265
Score = 804 bits (2077), Expect = 0.0
Identities = 461/1257 (36%), Positives = 700/1257 (55%), Gaps = 25/1257 (1%)
Frame = -1
Query: 3711 GLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALL----------------- 3583
GLF Y + D +LL +GTI A+I G P+LA+V G +T L
Sbjct: 37 GLFSYTRGKDLILLIVGTIAAVIHGAGFPLLAIVLGGMTTVFLRAQNSDFVVGVGNVNPN 96
Query: 3582 -VYPPTSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLR 3406
+ P + +F ++ + +L +G+ + +T+++Q CF+ ++ ++R ++ ++LR
Sbjct: 97 GLEPISIDEFNSEVVKYCIYYLILGVAMFVTSYVQIACFESYAENLVHKLRQNYLKAILR 156
Query: 3405 QNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASM 3226
Q WFDK +G +T +L D +ER+REG+GDK +L++ FA +A V + Y W + +
Sbjct: 157 QQIQWFDKQQTGNLTARLTDDLERVREGLGDKFALLVQMFAAFLAGYGVGFFYSWSMTLV 216
Query: 3225 MLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRY 3046
M+G AP + + +++ M + T E AG+IAEE+ +RTV + NG + + R+
Sbjct: 217 MMGFAPLIVLSGAKMSKSMATRTKVEQETYAVAGAIAEETFSSIRTVHSLNGHKRELDRF 276
Query: 3045 EAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVM 2866
LE GRK + K YG+ L+ G +F V
Sbjct: 277 WNALENGRKTGIVKYCYMGIGVGFSNLCMYSSYALAFWYGSTLIINDPTFDRGLIFTVFF 336
Query: 2865 SMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFEN 2686
++L G+ LG PH+ AR +A ++ + I+ PKIDPYS G + N+ G + F+N
Sbjct: 337 AVLSGSTSLGGALPHLASFGTARGAAYTVLRVINSHPKIDPYSLEGLLVDNMKGDISFQN 396
Query: 2685 VHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGT 2506
VHFRYPSRKD +L G++L V+ G +ALVG SGCGKST V LL R Y+P G V+IDG
Sbjct: 397 VHFRYPSRKDIPVLKGISLEVKSGEKIALVGSSGCGKSTIVNLLQRFYDPTKGKVSIDGV 456
Query: 2505 DVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKM 2326
D++E+N+ LR +GIV QEP+LF+ TI+ N+ +GN +T + ++E CKMANA+DFI+++
Sbjct: 457 DLKEINVHSLREQIGIVSQEPVLFDGTIYENIKMGNEHATHDQVVEACKMANANDFIKRL 516
Query: 2325 PKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNA 2146
P GY T +G+ GVQLSGGQKQR+AIAR L+++PK+LLLDEATSALD ++E VQ+AL+ A
Sbjct: 517 PDGYGTRVGEKGVQLSGGQKQRIAIARALVKNPKILLLDEATSALDTEAEREVQAALDQA 576
Query: 2145 SKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKADPX 1966
GRTT+++AHRLSTIR DKI F+ G IVE G+HEEL+ G ++D+ +AQ +
Sbjct: 577 QAGRTTLIVAHRLSTIRNVDKIFVFKAGNIVETGSHEELMNKQGVFYDMTQAQVVRQQQQ 636
Query: 1965 XXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXXXXXX 1786
D++DT S++S
Sbjct: 637 EAGK------DIEDTISESAHSHL----------------------SRKSSTRSAISMAT 668
Query: 1785 XXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVF-ALIRGLELPALALIFGWVFEG 1609
E+ + + N + ++ F+G +F A I G P AL++ +F
Sbjct: 669 SIHQLAEEVEECKAPPTPISKIFNFNRDKIWWFIGGMFGAFIFGSVTPVFALVYAEIFN- 727
Query: 1608 FTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLY 1429
+ +M + F +G+ + S+ E+L+M+ R ++F+NL+
Sbjct: 728 -VYSEPVEQMQSDVYFWCGMFVLMGITFFIGFFISANCLGRCGESLTMKLRFEAFKNLMR 786
Query: 1428 QDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXX 1249
QD +++D+ H GKL TR A+DAPN++ V R+ V Y WQ
Sbjct: 787 QDIAFYDDLRHGTGKLCTRFATDAPNVRYVF-TRLPVVLASIVTILGALGIGFYYGWQ-- 843
Query: 1248 XXXXXXXXXLAFVMIGLAYKISLMNVEQIQN----DDAGRIAIEIIENVKTIQLLTRCEL 1081
+ +++G +++ + +QI++ ++AG++A + +E+++T+ L R E
Sbjct: 844 -LALILVVMVPLLVMGGYFEMQMRFGKQIRDTQLLEEAGKVASQAVEHIRTVHSLNRQEQ 902
Query: 1080 FFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTF 901
F Y ++ + LK ++ +QS ++FM + +G + Q D +
Sbjct: 903 FHFTYCEYLREPFNTNLKHAHTYGAVFAFSQSLIFFMYAVAFYLGSIFVNQHSMQPIDVY 962
Query: 900 KGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLME-GDRPEIRGNIL 724
+ A+ + N+ + P+ VKA+ AA +LF +I L E G I GNI
Sbjct: 963 RVFFAISFCGQMIGNTTSFIPDVVKARLAASLLFYLIEHPTPIDSLSEAGIVKPITGNIS 1022
Query: 723 FENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRI 544
N+ F+YP R +++G GQTVALVG SG GKST +G+LERFY+ G + I
Sbjct: 1023 IRNIFFNYPTRKETKVLQGFTIDIKPGQTVALVGHSGCGKSTIMGLLERFYNQDKGMIMI 1082
Query: 543 DGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGL-KDVPLEKINQALELANANRF 367
DG +IR L++ LR Q+ +V QEP LF TI EN+C G ++V ++I +A ++AN + F
Sbjct: 1083 DGDNIRNLNISSLRQQVCIVSQEPTLFDCTIGENICYGTNRNVTYQEIVEAAKMANIHNF 1142
Query: 366 LANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEA 187
+ LP G DT VGEKG QLSGGQKQRIAIARALVR P +LLLDEATSALD+ESE+ VQEA
Sbjct: 1143 ILGLPDGYDTHVGEKGTQLSGGQKQRIAIARALVRSPSVLLLDEATSALDTESEKIVQEA 1202
Query: 186 LDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQ 16
LD A++GRTC+ IAHRLS+IQNSD+I + +GK+ + G H +LM + Y KL + Q
Sbjct: 1203 LDAAKQGRTCLVIAHRLSTIQNSDVIAIVSEGKIVDKGTHDELMRKSEIYQKLCETQ 1259
Score = 321 bits (822), Expect = 1e-85
Identities = 200/595 (33%), Positives = 321/595 (53%), Gaps = 8/595 (1%)
Frame = -1
Query: 3744 QQLEAQPVSIPGLFRYGKKFDYLLLFIGTIC-AIISGVSQPILALVSGRVTNALLVYPPT 3568
++ +A P I +F + + D + FIG + A I G P+ ALV + N VY
Sbjct: 678 EECKAPPTPISKIFNFNR--DKIWWFIGGMFGAFIFGSVTPVFALVYAEIFN---VYSEP 732
Query: 3567 SKQFRNKANENVYIFLGIGIFISITNFIQYM----CFQHCCTRVMAQMRHRFVYSVLRQN 3400
+Q ++ +VY + G+ + + IT FI + C C + ++R +++RQ+
Sbjct: 733 VEQMQS----DVYFWCGMFVLMGITFFIGFFISANCLGRCGESLTMKLRFEAFKNLMRQD 788
Query: 3399 AGWFD--KNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASM 3226
++D ++ +G + T+ +R + +L V+L ++ A+ + + Y W+LA +
Sbjct: 789 IAFYDDLRHGTGKLCTRFATDAPNVRY-VFTRLPVVLASIVTILGALGIGFYYGWQLALI 847
Query: 3225 MLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRY 3046
++ + P + + I++ + +AG +A +++ +RTV + N QE+ Y
Sbjct: 848 LVVMVPLLVMGGYFEMQMRFGKQIRDTQLLEEAGKVASQAVEHIRTVHSLNRQEQFHFTY 907
Query: 3045 EAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVM 2866
L + + G+ + + P DV+ V
Sbjct: 908 CEYLREPFNTNLKHAHTYGAVFAFSQSLIFFMYAVAFYLGSIFVNQHSMQ-PIDVYRVFF 966
Query: 2865 SMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFEN 2686
++ +G + + ++ AR++A+ ++ I+ ID S+AG ++ + G + N
Sbjct: 967 AISFCGQMIGNTTSFIPDVVKARLAASLLFYLIEHPTPIDSLSEAGI-VKPITGNISIRN 1025
Query: 2685 VHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGT 2506
+ F YP+RK+ K+L G + ++PG +VALVGHSGCGKST +GLL R Y + G + IDG
Sbjct: 1026 IFFNYPTRKETKVLQGFTIDIKPGQTVALVGHSGCGKSTIMGLLERFYNQDKGMIMIDGD 1085
Query: 2505 DVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIG-NPGSTRETMIEVCKMANAHDFIEK 2329
++R LNI LR V IV QEP LF+ TI N+ G N T + ++E KMAN H+FI
Sbjct: 1086 NIRNLNISSLRQQVCIVSQEPTLFDCTIGENICYGTNRNVTYQEIVEAAKMANIHNFILG 1145
Query: 2328 MPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNN 2149
+P GYDT +G+ G QLSGGQKQR+AIAR L+R P VLLLDEATSALD +SE IVQ AL+
Sbjct: 1146 LPDGYDTHVGEKGTQLSGGQKQRIAIARALVRSPSVLLLDEATSALDTESEKIVQEALDA 1205
Query: 2148 ASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQ 1984
A +GRT ++IAHRLSTI+ +D I +G IV+ G H+EL+R Y L + Q+
Sbjct: 1206 AKQGRTCLVIAHRLSTIQNSDVIAIVSEGKIVDKGTHDELMRKSEIYQKLCETQR 1260
>gi|45382457|ref|NP_990225.1| ABC transporter protein [Gallus gallus]
gi|3355757|emb|CAA08835.1| ABC transporter protein; P-glycoprotein
[Gallus gallus]
Length = 1288
Score = 801 bits (2070), Expect = 0.0
Identities = 472/1260 (37%), Positives = 694/1260 (54%), Gaps = 22/1260 (1%)
Frame = -1
Query: 3729 QPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPT------ 3568
Q VS LFRY D LL+ G++ AI G S PI ++ G +T++ + T
Sbjct: 43 QMVSPLALFRYSSCTDKLLMIFGSLLAIAHGTSLPIAMIIFGDMTDSFVTSGMTNITGNS 102
Query: 3567 -----SKQFRNKANENV----YIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYS 3415
S NK E + Y + I + + +IQ + R + ++R +F ++
Sbjct: 103 SGLNSSADVFNKLEEEMTRYAYYYSAIAAAVLVAAYIQTSFWTLAAGRQVKKIREKFFHA 162
Query: 3414 VLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRL 3235
++RQ GWFD N +G + T+L D + +I EGIGDK+G L++ + +V +I W+L
Sbjct: 163 IMRQEIGWFDVNDAGELNTRLIDDVSKINEGIGDKIGFLIQSETTFLTGFIVGFIRGWKL 222
Query: 3234 ASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMV 3055
++L V+P + +L A+ +T+ T KE KAG++AEE L VRTV AF GQE+ +
Sbjct: 223 TLVILAVSPVLGLSAALWAKILTAFTDKEQAAYAKAGAVAEEVLSAVRTVIAFGGQEKEI 282
Query: 3054 GRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFI 2875
RY LE ++ + K YG L+ + G+V
Sbjct: 283 KRYHKNLEDAKRIGIRKAITSNISMGAAFLLIYASYALAFWYGTTLILANEYSI-GNVLT 341
Query: 2874 VVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVK 2695
V S+L+GA+ +G +P + NAR +A +I+ ID P+ID YS AG + ++ G ++
Sbjct: 342 VFFSVLIGAFSIGQTAPSIEAFANARGAAYAIFNIIDNEPEIDSYSDAGHKPDHIKGNLE 401
Query: 2694 FENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTI 2515
F+NV F YPSR D +IL GLNL V G +VALVG SGCGKST+V L+ R Y+P+ G +TI
Sbjct: 402 FQNVFFNYPSRPDVEILKGLNLKVNCGQTVALVGGSGCGKSTTVQLIQRFYDPKEGTITI 461
Query: 2514 DGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFI 2335
DG D++ LN+ +LR +G+V QEP+LF TI N+ G T E + K ANA+DFI
Sbjct: 462 DGQDLKSLNVRYLREIIGVVNQEPVLFATTIAENIRYGREDVTMEEIERATKEANAYDFI 521
Query: 2334 EKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSAL 2155
K+PK ++T++G+ G Q+SGGQKQR+AIAR L+ +PK+LLLDEATSALD +SES+VQ+AL
Sbjct: 522 MKLPKKFETVVGERGAQMSGGQKQRIAIARALVHNPKILLLDEATSALDTESESVVQAAL 581
Query: 2154 NNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKA 1975
+ A +GRTT+++AHRLST+R AD I FE GVI E GNH +L+ G Y+ LV Q +
Sbjct: 582 DKAREGRTTVVVAHRLSTVRNADLIAVFESGVITEQGNHSQLIEKKGIYYKLVNMQTIET 641
Query: 1974 -DPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXX 1798
DP + + RRG++ + +
Sbjct: 642 EDPSSEKSENAVSV-------KRSGSQSNLDESLKKELRRGSTRRSMKKPGEPN------ 688
Query: 1797 XXXXXXXXXXXXXEDGQI-TAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGW 1621
D ++ +L + K K + Y GT A++ G PA ++IF
Sbjct: 689 -----DTDEKGSSPDEELPPVSFLKLMKLNKNEWPYFVAGTFCAIVNGALQPAFSVIFSE 743
Query: 1620 VFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFR 1441
+ F+ + + + + F ++G+ +F+ F E L+M+ R +F+
Sbjct: 744 IIGIFSETDQ-KVLREKSNLYSLLFLALGIISFFTFFVQGFAFGKAGEILTMKLRFMAFK 802
Query: 1440 NLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYC 1261
+L QD ++FD+P ++ G L TRLA+DA +K R+ + +Y
Sbjct: 803 AMLRQDMAWFDDPKNSTGALTTRLANDASQVKGATGVRLALIAQNIANLGTGIIISLVYG 862
Query: 1260 WQXXXXXXXXXXXLAFV-MIGLAYKISLMNVEQIQNDDAGRIAIEIIENVKTIQLLTRCE 1084
WQ +A MI + ++I+ + AG+IA E IEN++T+ LTR +
Sbjct: 863 WQLTLLLLAVVPIIAVAGMIEMKMLAGHAKKDKIELEAAGKIATEAIENIRTVASLTREK 922
Query: 1083 LFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDT 904
F Y R+ +KK I +SL+Q+ M+F + G ++ G
Sbjct: 923 RFELMYGEHLLVPYRNSVKKAHIFGFCFSLSQAMMFFTYAGCFRFGAYLVVNGHIEYKTV 982
Query: 903 FKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLME-GDRPE-IRGN 730
F A++ GA+A+ ++ + P++ KAK +A LF + R P E G++PE GN
Sbjct: 983 FLVFSAVVFGAMALGQTSSFAPDYAKAKISAAHLFVLFNRVPPIDSYREDGEKPEKFGGN 1042
Query: 729 ILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGAL 550
++VKF+YP RP I++GL +G+T+ALVG SG GKST + +LERFYD G +
Sbjct: 1043 TRIKDVKFNYPNRPEVKILQGLNLAVEKGETLALVGSSGCGKSTVVQLLERFYDPLSGEI 1102
Query: 549 RIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG--LKDVPLEKINQALELANA 376
D D + L++ LR+ + +V QEP LF TI EN+ G ++V E+I A + A+
Sbjct: 1103 VFDDIDAKTLNIQWLRSHIGIVSQEPILFDFTIAENIAYGDNSREVSHEEIISAAKAASI 1162
Query: 375 NRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAV 196
+ F+ +LP +T VG+KG QLSGGQKQRIAIARAL+R P+ILLLDEATSALD+ESE+ V
Sbjct: 1163 HSFIDSLPEKYNTRVGDKGTQLSGGQKQRIAIARALIRKPQILLLDEATSALDTESEKIV 1222
Query: 195 QEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQ 16
QEALD+AREGRTCI IAHRLS+IQN+D I I GKV E G H QL+ +KG YY L+ Q
Sbjct: 1223 QEALDKAREGRTCIVIAHRLSTIQNADKIAVIQNGKVIEQGTHQQLLAEKGFYYSLVNVQ 1282
Score = 382 bits (980), Expect = e-104
Identities = 220/588 (37%), Positives = 328/588 (55%), Gaps = 5/588 (0%)
Frame = -1
Query: 3735 EAQPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTS-KQ 3559
E PVS L + K ++ GT CAI++G QP +++ + ++ T K
Sbjct: 700 ELPPVSFLKLMKLNKN-EWPYFVAGTFCAIVNGALQPAFSVIFSEIIG---IFSETDQKV 755
Query: 3558 FRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFD-- 3385
R K+N +FL +GI T F+Q F + ++R ++LRQ+ WFD
Sbjct: 756 LREKSNLYSLLFLALGIISFFTFFVQGFAFGKAGEILTMKLRFMAFKAMLRQDMAWFDDP 815
Query: 3384 KNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPT 3205
KN +G +TT+L + +++ G +L ++ + A L I+++ +Y W+L ++L V P
Sbjct: 816 KNSTGALTTRLANDASQVKGATGVRLALIAQNIANLGTGIIISLVYGWQLTLLLLAVVPI 875
Query: 3204 CCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKG 3025
+ + + + K+ I + AG IA E++ +RTV + ++ Y L
Sbjct: 876 IAVAGMIEMKMLAGHAKKDKIELEAAGKIATEAIENIRTVASLTREKRFELMYGEHLLVP 935
Query: 3024 RKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAY 2845
+ +V K +GAYL+ G I VF+V +++ GA
Sbjct: 936 YRNSVKKAHIFGFCFSLSQAMMFFTYAGCFRFGAYLVVNGHIEYK-TVFLVFSAVVFGAM 994
Query: 2844 FLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPS 2665
LG S A++SAA ++ +RVP ID Y + G++ + G + ++V F YP+
Sbjct: 995 ALGQTSSFAPDYAKAKISAAHLFVLFNRVPPIDSYREDGEKPEKFGGNTRIKDVKFNYPN 1054
Query: 2664 RKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNI 2485
R + KIL GLNL VE G ++ALVG SGCGKST V LL R Y+P +G + D D + LNI
Sbjct: 1055 RPEVKILQGLNLAVEKGETLALVGSSGCGKSTVVQLLERFYDPLSGEIVFDDIDAKTLNI 1114
Query: 2484 EWLRNTVGIVQQEPILFNDTIHNNLLIGNPGS--TRETMIEVCKMANAHDFIEKMPKGYD 2311
+WLR+ +GIV QEPILF+ TI N+ G+ + E +I K A+ H FI+ +P+ Y+
Sbjct: 1115 QWLRSHIGIVSQEPILFDFTIAENIAYGDNSREVSHEEIISAAKAASIHSFIDSLPEKYN 1174
Query: 2310 TLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRT 2131
T +GD G QLSGGQKQR+AIAR LIR P++LLLDEATSALD +SE IVQ AL+ A +GRT
Sbjct: 1175 TRVGDKGTQLSGGQKQRIAIARALIRKPQILLLDEATSALDTESEKIVQEALDKAREGRT 1234
Query: 2130 TIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQ 1987
I+IAHRLSTI+ ADKI + G ++E G H++L+ G Y+ LV Q
Sbjct: 1235 CIVIAHRLSTIQNADKIAVIQNGKVIEQGTHQQLLAEKGFYYSLVNVQ 1282
Score = 319 bits (817), Expect = 4e-85
Identities = 202/583 (34%), Positives = 307/583 (52%), Gaps = 20/583 (3%)
Frame = -1
Query: 1698 LYMFLGTVFALIRGLELPALALIFG-----WVFEGFTFVPYGG-----------RMMHRM 1567
L M G++ A+ G LP +IFG +V G T + ++ M
Sbjct: 60 LLMIFGSLLAIAHGTSLPIAMIIFGDMTDSFVTSGMTNITGNSSGLNSSADVFNKLEEEM 119
Query: 1566 AMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPG 1387
++++ V + + + + + + R + F ++ Q+ +FD + G
Sbjct: 120 TRYAYYYSAIAAAVLVAAYIQTSFWTLAAGRQVKKIREKFFHAIMRQEIGWFD--VNDAG 177
Query: 1386 KLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVM 1207
+L TRL D I + ++ + I W+ L +
Sbjct: 178 ELNTRLIDDVSKINEGIGDKIGFLIQSETTFLTGFIVGFIRGWKLTLVILAVSPVLG-LS 236
Query: 1206 IGLAYKI--SLMNVEQIQNDDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSE 1033
L KI + + EQ AG +A E++ V+T+ E Y + + KR
Sbjct: 237 AALWAKILTAFTDKEQAAYAKAGAVAEEVLSAVRTVIAFGGQEKEIKRYHKNLEDAKRIG 296
Query: 1032 LKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNS 853
++K + I+ +Y + G +I + S + ++++GA ++ +
Sbjct: 297 IRKAITSNISMGAAFLLIYASYALAFWYGTTLILANEYSIGNVLTVFFSVLIGAFSIGQT 356
Query: 852 AQYFPEFVKAKTAAGMLFNIIYRKPRTGDLME-GDRPE-IRGNILFENVKFSYPQRPLQP 679
A F A+ AA +FNII +P + G +P+ I+GN+ F+NV F+YP RP
Sbjct: 357 APSIEAFANARGAAYAIFNIIDNEPEIDSYSDAGHKPDHIKGNLEFQNVFFNYPSRPDVE 416
Query: 678 IMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRT 499
I+KGL GQTVALVG SG GKST + +++RFYD G + IDGQD++ L++ +LR
Sbjct: 417 ILKGLNLKVNCGQTVALVGGSGCGKSTTVQLIQRFYDPKEGTITIDGQDLKSLNVRYLRE 476
Query: 498 QMALVGQEPRLFAGTIRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGEKG 319
+ +V QEP LFA TI EN+ G +DV +E+I +A + ANA F+ LP +T VGE+G
Sbjct: 477 IIGVVNQEPVLFATTIAENIRYGREDVTMEEIERATKEANAYDFIMKLPKKFETVVGERG 536
Query: 318 GQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHR 139
Q+SGGQKQRIAIARALV +PKILLLDEATSALD+ESE VQ ALD+AREGRT + +AHR
Sbjct: 537 AQMSGGQKQRIAIARALVHNPKILLLDEATSALDTESESVVQAALDKAREGRTTVVVAHR 596
Query: 138 LSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQDL 10
LS+++N+DLI + G + E GNH+QL+ +KG YYKL+ Q +
Sbjct: 597 LSTVRNADLIAVFESGVITEQGNHSQLIEKKGIYYKLVNMQTI 639
>gi|6679297|ref|NP_032856.1| ATP-binding cassette, sub-family B
(MDR/TAP), member 4; P glycoprotein 2 [Mus musculus]
gi|126929|sp|P21440|MDR2_MOUSE Multidrug resistance protein 2
(P-glycoprotein 2)
gi|72476|pir||DVMS2 multidrug resistance protein 2 - mouse
gi|387428|gb|AAA39516.1| multidrug resistance protein
Length = 1276
Score = 800 bits (2065), Expect = 0.0
Identities = 483/1274 (37%), Positives = 710/1274 (54%), Gaps = 26/1274 (2%)
Frame = -1
Query: 3759 GDIANQQLEAQP----VSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVT- 3595
G I+NQ E + + + LFRY D L +F+GT+ AI G P++ +V G +T
Sbjct: 21 GSISNQGREKKKKVNLIGLLTLFRYSDWQDKLFMFLGTLMAIAHGSGLPLMMIVFGEMTD 80
Query: 3594 -------------NALLVYPPTSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCT 3454
N L + + Y + G+G + + +IQ +
Sbjct: 81 KFVDNTGNFSLPVNFSLSMLNPGRILEEEMTRYAYYYSGLGGGVLVAAYIQVSFWTLAAG 140
Query: 3453 RVMAQMRHRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLI 3274
R + ++R +F +++LRQ GWFD + + T+L D + +I EGIGDK+G+ + A
Sbjct: 141 RQIKKIRQKFFHAILRQEMGWFDIKGTTELNTRLTDDVSKISEGIGDKVGMFFQAIATFF 200
Query: 3273 AAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGV 3094
A +V +I W+L +++ ++P + ++ A+ +++ + KEL KAG++AEE+ +
Sbjct: 201 AGFIVGFIRGWKLTLVIMAISPILGLSTAVWAKILSTFSDKELAAYAKAGAVAEEAPGAI 260
Query: 3093 RTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLL 2914
RTV AF GQ + + RY+ LE +K + K YG+ L+
Sbjct: 261 RTVIAFGGQNKELERYQKHLENAKKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLV 320
Query: 2913 KVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSK 2734
+ T G+ V S+L+GA+ +G +P + NAR +A I+ ID PKID +S+
Sbjct: 321 -ISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSE 379
Query: 2733 AGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLL 2554
G + N+ G ++F +VHF YPSR + KIL GLNL V+ G +VALVG+SGCGKST+V LL
Sbjct: 380 RGHKPDNIKGNLEFSDVHFSYPSRANIKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLL 439
Query: 2553 TRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETM 2374
RLY+P G ++IDG D+R N+ LR +G+V QEP+LF+ TI N+ G T + +
Sbjct: 440 QRLYDPTEGKISIDGQDIRNFNVRCLREIIGVVSQEPVLFSTTIAENIRYGRGNVTMDEI 499
Query: 2373 IEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSA 2194
+ K ANA+DFI K+P+ +DTL+GD G QLSGGQKQR+AIAR L+R+PK+LLLDEATSA
Sbjct: 500 EKAVKEANAYDFIMKLPQKFDTLVGDRGAQLSGGQKQRIAIARALVRNPKILLLDEATSA 559
Query: 2193 LDAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGG 2014
LD +SE+ VQ+AL+ A +GRTTI+IAHRLSTIR AD I FE GVIVE G+H EL++ G
Sbjct: 560 LDTESEAEVQAALDKAREGRTTIVIAHRLSTIRNADVIAGFEDGVIVEQGSHSELMKKEG 619
Query: 2013 RYFDLVKAQQFKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSF 1834
YF LV Q E++L D + FR NS S
Sbjct: 620 IYFRLVNMQ----TAGSQILSEEFEVELSD---EKAAGDVAPNGWKARIFR--NSTKKSL 670
Query: 1833 SGSKRSXXXXXXXXXXXXXXXXXXXEDGQI-TAGYLDIFKNAKGNYLYMFLGTVFALIRG 1657
++ D + +L + K K + Y +GTV A+ G
Sbjct: 671 KSPHQN-----------RLDEETNELDANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANG 719
Query: 1656 LELPALALIFGWVFEGFTFVPYGGRM-MHRMAMAVIAFASVGVGVWFSQLASSVLFAVVS 1480
PA ++I + F P + + M + F +GV +F+ F
Sbjct: 720 ALQPAFSIILSEMIA--IFGPGDDAVKQQKCNMFSLVFLGLGVLSFFTFFLQGFTFGKAG 777
Query: 1479 ENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXX 1300
E L+ R R +F+ +L QD S+FD+ ++ G L TRLA+DA ++ ++ +
Sbjct: 778 EILTTRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTKLALIAQNTA 837
Query: 1299 XXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNV--EQIQNDDAGRIAIEI 1126
IY WQ +A I + K+ N ++ + + AG+IA E
Sbjct: 838 NLGTGIIISFIYGWQLTLLLLSVVPFIAVAGI-VEMKMLAGNAKRDKKEMEAAGKIATEA 896
Query: 1125 IENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVG 946
IEN++T+ LT+ F Y R+ ++K I I +S++Q+FMYF + G
Sbjct: 897 IENIRTVVSLTQERKFESMYVEKLHGPYRNSVRKAHIYGITFSISQAFMYFSYAGCFRFG 956
Query: 945 IRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGD 766
+I G D A++LGAVA+ +++ + P++ KAK +A LF++ R+P
Sbjct: 957 SYLIVNGHMRFKDVILVFSAIVLGAVALGHASSFAPDYAKAKLSAAYLFSLFERQPLIDS 1016
Query: 765 LM-EGDRPE-IRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNI 592
EG P+ G++ F V F+YP R P+++GL +GQT+ALVG SG GKST +
Sbjct: 1017 YSGEGLWPDKFEGSVTFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVV 1076
Query: 591 GMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG--LKDV 418
+LERFYD G++ +DGQ+ +KL++ LR Q+ +V QEP LF +I EN+ G + V
Sbjct: 1077 QLLERFYDPMAGSVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVV 1136
Query: 417 PLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLD 238
P ++I +A + AN + F+ LP +T VG+KG QLSGGQKQRIAIARAL+R P++LLLD
Sbjct: 1137 PHDEIVRAAKEANIHPFIETLPQKYNTRVGDKGTQLSGGQKQRIAIARALIRQPRVLLLD 1196
Query: 237 EATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQL 58
EATSALD+ESE+ VQEALD+AREGRTCI IAHRLS+IQN+DLIV I+ GKV+E G H QL
Sbjct: 1197 EATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIENGKVKEHGTHQQL 1256
Query: 57 MHQKGRYYKLIKKQ 16
+ QKG Y+ ++ Q
Sbjct: 1257 LAQKGIYFSMVNIQ 1270
Score = 368 bits (944), Expect = e-100
Identities = 224/637 (35%), Positives = 345/637 (53%), Gaps = 7/637 (1%)
Frame = -1
Query: 3876 SDPKIASDLPANYVDDDDDAPKMYTPSLLEKILNYALCRGDIANQQLEAQ--PVSIPGLF 3703
SD K A D+ N +++ S + + + R D +L+A PVS +
Sbjct: 644 SDEKAAGDVAPN-----GWKARIFRNSTKKSLKSPHQNRLDEETNELDANVPPVSFLKVL 698
Query: 3702 RYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRN-KANENVYI 3526
+ K ++ +GT+CAI +G QP +++ ++ + ++ P + K N +
Sbjct: 699 KLNKT-EWPYFVVGTVCAIANGALQPAFSII---LSEMIAIFGPGDDAVKQQKCNMFSLV 754
Query: 3525 FLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFD--KNHSGTITTKL 3352
FLG+G+ T F+Q F + ++R ++LRQ+ WFD KN +G ++T+L
Sbjct: 755 FLGLGVLSFFTFFLQGFTFGKAGEILTTRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRL 814
Query: 3351 NDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQ 3172
+++ G KL ++ + A L I++++IY W+L ++L V P + + +
Sbjct: 815 ATDAAQVQGATGTKLALIAQNTANLGTGIIISFIYGWQLTLLLLSVVPFIAVAGIVEMKM 874
Query: 3171 MTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXX 2992
+ ++ + AG IA E++ +RTV + + + Y +L + +V K
Sbjct: 875 LAGNAKRDKKEMEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLHGPYRNSVRKAHIY 934
Query: 2991 XXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMV 2812
+G+YL+ G + DV +V +++LGA LG S
Sbjct: 935 GITFSISQAFMYFSYAGCFRFGSYLIVNGHMRFK-DVILVFSAIVLGAVALGHASSFAPD 993
Query: 2811 LLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLN 2632
A++SAA ++ +R P ID YS G G V F V F YP+R + +L GL+
Sbjct: 994 YAKAKLSAAYLFSLFERQPLIDSYSGEGLWPDKFEGSVTFNEVVFNYPTRANVPVLQGLS 1053
Query: 2631 LVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQ 2452
L V+ G ++ALVG SGCGKST V LL R Y+P AG+V +DG + ++LN++WLR +GIV
Sbjct: 1054 LEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVLLDGQEAKKLNVQWLRAQLGIVS 1113
Query: 2451 QEPILFNDTIHNNLLIGNPGST--RETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLS 2278
QEPILF+ +I N+ G+ + ++ K AN H FIE +P+ Y+T +GD G QLS
Sbjct: 1114 QEPILFDCSIAENIAYGDNSRVVPHDEIVRAAKEANIHPFIETLPQKYNTRVGDKGTQLS 1173
Query: 2277 GGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTI 2098
GGQKQR+AIAR LIR P+VLLLDEATSALD +SE +VQ AL+ A +GRT I+IAHRLSTI
Sbjct: 1174 GGQKQRIAIARALIRQPRVLLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTI 1233
Query: 2097 READKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQ 1987
+ AD IV E G + E G H++L+ G YF +V Q
Sbjct: 1234 QNADLIVVIENGKVKEHGTHQQLLAQKGIYFSMVNIQ 1270
>gi|17508505|ref|NP_491707.1| P-GlycoProtein related (pgp-2)
[Caenorhabditis elegans]
gi|15617726|gb|AAB52482.2| P-glycoprotein related protein 2
[Caenorhabditis elegans]
Length = 1265
Score = 798 bits (2062), Expect = 0.0
Identities = 460/1257 (36%), Positives = 698/1257 (54%), Gaps = 25/1257 (1%)
Frame = -1
Query: 3711 GLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALL----------------- 3583
G+F Y + D LLL GT+ A+I G P+LA+V G +T L
Sbjct: 37 GIFYYTQGVDLLLLITGTVAAVIHGAGFPLLAIVLGGMTTVFLRAQNSDFVVGVDNVNPE 96
Query: 3582 -VYPPTSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLR 3406
+ P + +F ++ + +L +G+ + T+++Q CF+ R++ ++R ++ ++LR
Sbjct: 97 GLVPISLDEFNSEVVKYCIYYLVLGVLMFFTSYVQIACFESYAERLVHKLRQNYLKAILR 156
Query: 3405 QNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASM 3226
Q WFDK +G +T +L D +ER+REG+GDK +L++ FA +A V + Y W + +
Sbjct: 157 QQIQWFDKQQTGNLTARLTDDLERVREGLGDKFALLVQMFAAFLAGYGVGFFYSWSMTLV 216
Query: 3225 MLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRY 3046
M+G AP + + +++ M + T E AG+IAEE+ +RTV + NG + + R+
Sbjct: 217 MMGFAPLIVLSGAKMSKSMATRTRVEQETYAVAGAIAEETFSSIRTVHSLNGHKRELDRF 276
Query: 3045 EAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVM 2866
LE GR+ + K YG+ L+ G +F V
Sbjct: 277 YNALEVGRQTGIVKYCYMGIGVGFSNLCMYSSYALAFWYGSTLIINDPTFDRGLIFTVFF 336
Query: 2865 SMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFEN 2686
++L G+ LG PH+ AR +A+++ + I+ PKIDPYS G + N+ G + F++
Sbjct: 337 AVLSGSTSLGGALPHLASFGTARGAASTVLRVINSHPKIDPYSLEGILVDNMKGDISFKD 396
Query: 2685 VHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGT 2506
VHFRYPSRKD +L G++L ++ G +ALVG SGCGKST V LL R Y+P G V IDG
Sbjct: 397 VHFRYPSRKDIHVLKGISLELKAGDKIALVGSSGCGKSTIVNLLQRFYDPTKGRVLIDGV 456
Query: 2505 DVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKM 2326
D+RE+N+ LR +GIV QEP+LF+ TI+ N+ +GN +T + ++E CKMANA+DFI+++
Sbjct: 457 DLREVNVHSLREQIGIVSQEPVLFDGTIYENIKMGNEHATHDQVVEACKMANANDFIKRL 516
Query: 2325 PKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNA 2146
P GY T +G+ GVQLSGGQKQR+AIAR L+++PK+LLLDEATSALD ++E VQ AL+ A
Sbjct: 517 PDGYGTRVGEKGVQLSGGQKQRIAIARALVKNPKILLLDEATSALDTEAEREVQGALDQA 576
Query: 2145 SKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKADPX 1966
GRTTI++AHRLSTIR D+I F+ G IVE+G+HEEL+ G ++D+ +AQ +
Sbjct: 577 QAGRTTIIVAHRLSTIRNVDRIFVFKAGNIVESGSHEELMSKQGIFYDMTQAQVVRQQQQ 636
Query: 1965 XXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXXXXXX 1786
D++DT A S++ +
Sbjct: 637 EAGK------DIEDTISESAHSHLSRKSSTRSAISIATSIHQLAEEVEECKAP------- 683
Query: 1785 XXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVF-ALIRGLELPALALIFGWVFEG 1609
IFK G+ + F+G +F A I G P AL++ +F
Sbjct: 684 --------------PTSMFKIFK-FNGDKVGWFIGGIFGAFIFGSVTPVFALVYAEIFNV 728
Query: 1608 FTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLY 1429
++ +M + F +G+ + S+ E+L+M+ R ++F+NLL
Sbjct: 729 YSLP--ADQMQANVYFWCGMFVLMGITFFVGFFTSANCLGRCGESLTMKLRFEAFKNLLR 786
Query: 1428 QDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXX 1249
QD +++D+ H GKL TR A+DAPN++ V R+ V Y WQ
Sbjct: 787 QDIAFYDDLRHGTGKLCTRFATDAPNVRYVF-TRLPVVLASIVTICGALGIGFYYGWQ-- 843
Query: 1248 XXXXXXXXXLAFVMIGLAYKISLMNVEQIQN----DDAGRIAIEIIENVKTIQLLTRCEL 1081
+ +++G +++ + +QI++ ++AG++A + +E+++T+ L R E
Sbjct: 844 -LALILVVMVPLLVMGGYFEMQMRFGKQIRDTQLLEEAGKVASQAVEHIRTVHSLNRQEQ 902
Query: 1080 FFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTF 901
F Y ++ + LK ++ +QS ++FM + +G + Q D +
Sbjct: 903 FHFTYCEYLREPFNTNLKHAHTYGAVFAFSQSLIFFMYAAAFYLGSIFVNQQAMQPIDVY 962
Query: 900 KGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLME-GDRPEIRGNIL 724
+ A+ + N+ + P+ VKA+ AA +LF +I L + G I GNI
Sbjct: 963 RVFFAISFCGQMIGNTTSFIPDVVKARLAASLLFYLIEHPTPIDSLSDSGIVKPITGNIS 1022
Query: 723 FENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRI 544
NV F+YP R +++G G+TVALVG SG GKST +G+LERFY+ G + I
Sbjct: 1023 IRNVFFNYPTRKDTKVLQGFTLDIKAGKTVALVGHSGCGKSTIMGLLERFYNQDKGMIMI 1082
Query: 543 DGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGL-KDVPLEKINQALELANANRF 367
DG +IR L++ LR Q+ +V QEP LF TI EN+C G ++V ++I +A ++AN + F
Sbjct: 1083 DGDNIRNLNISSLREQVCIVSQEPTLFDCTIGENICYGTNRNVTYQEIVEAAKMANIHNF 1142
Query: 366 LANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEA 187
+ LP G DT VGEKG QLSGGQKQRIAIARALVR P +LLLDEATSALD+ESE+ VQEA
Sbjct: 1143 ILGLPDGYDTHVGEKGTQLSGGQKQRIAIARALVRSPSVLLLDEATSALDTESEKIVQEA 1202
Query: 186 LDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQ 16
LD A++GRTC+ IAHRLS+IQNSD+I + +GK+ E G H +L+ + Y K + Q
Sbjct: 1203 LDAAKQGRTCLVIAHRLSTIQNSDVIAIVSEGKIVEKGTHDELIRKSEIYQKFCETQ 1259
Score = 318 bits (816), Expect = 5e-85
Identities = 203/595 (34%), Positives = 317/595 (53%), Gaps = 8/595 (1%)
Frame = -1
Query: 3744 QQLEAQPVSIPGLFRYGKKFDYLLLFIGTIC-AIISGVSQPILALVSGRVTNALLVYPPT 3568
++ +A P S+ +F++ D + FIG I A I G P+ ALV + N VY
Sbjct: 678 EECKAPPTSMFKIFKFNG--DKVGWFIGGIFGAFIFGSVTPVFALVYAEIFN---VYSLP 732
Query: 3567 SKQFRNKANENVYIFLGIGIFISITNFIQYM----CFQHCCTRVMAQMRHRFVYSVLRQN 3400
+ Q + NVY + G+ + + IT F+ + C C + ++R ++LRQ+
Sbjct: 733 ADQMQ----ANVYFWCGMFVLMGITFFVGFFTSANCLGRCGESLTMKLRFEAFKNLLRQD 788
Query: 3399 AGWFD--KNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASM 3226
++D ++ +G + T+ +R + +L V+L + A+ + + Y W+LA +
Sbjct: 789 IAFYDDLRHGTGKLCTRFATDAPNVRY-VFTRLPVVLASIVTICGALGIGFYYGWQLALI 847
Query: 3225 MLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRY 3046
++ + P + + I++ + +AG +A +++ +RTV + N QE+ Y
Sbjct: 848 LVVMVPLLVMGGYFEMQMRFGKQIRDTQLLEEAGKVASQAVEHIRTVHSLNRQEQFHFTY 907
Query: 3045 EAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVM 2866
L + + G+ + + P DV+ V
Sbjct: 908 CEYLREPFNTNLKHAHTYGAVFAFSQSLIFFMYAAAFYLGSIFVNQQAMQ-PIDVYRVFF 966
Query: 2865 SMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFEN 2686
++ +G + + ++ AR++A+ ++ I+ ID S +G ++ + G + N
Sbjct: 967 AISFCGQMIGNTTSFIPDVVKARLAASLLFYLIEHPTPIDSLSDSGI-VKPITGNISIRN 1025
Query: 2685 VHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGT 2506
V F YP+RKD K+L G L ++ G +VALVGHSGCGKST +GLL R Y + G + IDG
Sbjct: 1026 VFFNYPTRKDTKVLQGFTLDIKAGKTVALVGHSGCGKSTIMGLLERFYNQDKGMIMIDGD 1085
Query: 2505 DVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIG-NPGSTRETMIEVCKMANAHDFIEK 2329
++R LNI LR V IV QEP LF+ TI N+ G N T + ++E KMAN H+FI
Sbjct: 1086 NIRNLNISSLREQVCIVSQEPTLFDCTIGENICYGTNRNVTYQEIVEAAKMANIHNFILG 1145
Query: 2328 MPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNN 2149
+P GYDT +G+ G QLSGGQKQR+AIAR L+R P VLLLDEATSALD +SE IVQ AL+
Sbjct: 1146 LPDGYDTHVGEKGTQLSGGQKQRIAIARALVRSPSVLLLDEATSALDTESEKIVQEALDA 1205
Query: 2148 ASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQ 1984
A +GRT ++IAHRLSTI+ +D I +G IVE G H+EL+R Y + Q+
Sbjct: 1206 AKQGRTCLVIAHRLSTIQNSDVIAIVSEGKIVEKGTHDELIRKSEIYQKFCETQR 1260
>gi|2149087|gb|AAB58489.1| multidrug resistance protein-1 [Ovis aries]
Length = 1285
Score = 798 bits (2062), Expect = 0.0
Identities = 472/1275 (37%), Positives = 702/1275 (55%), Gaps = 31/1275 (2%)
Frame = -1
Query: 3747 NQQLEAQP-VSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNAL----- 3586
+++ E +P VS +FRY D L + +GT+ AII G P++ LV G +T++
Sbjct: 29 DEKKEKRPTVSTFTMFRYSNWLDRLCMVLGTLAAIIHGAGLPLMMLVFGDMTDSFAGAGN 88
Query: 3585 --------------LVYPPTSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRV 3448
+ K+ + Y + GIG + I +IQ + R
Sbjct: 89 LGNITLSNISNTSTIDRTEYGKKLEKEMTTYAYYYSGIGAGVLIAAYIQVSFWCLAAGRQ 148
Query: 3447 MAQMRHRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAA 3268
+ ++R +F +++++Q GWFD + G + T+L + + +I EGIGDK+G+ + A
Sbjct: 149 VHRIRKQFFHAIMQQEIGWFDVHDVGKLNTRLTNDVSKINEGIGDKIGMFFQAMATFFTG 208
Query: 3267 IVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRT 3088
++ + W L ++L + P + ++ A+ ++S T K+L+ KAG++AEE L ++T
Sbjct: 209 FIIGFTTGWNLTLVILAIIPVLGLSAAIWAKILSSFTDKKLLAYAKAGAVAEEVLAAIKT 268
Query: 3087 VQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKV 2908
V AF GQ++ + RY LE+ ++ + K YG L+ +
Sbjct: 269 VIAFGGQKKELERYNKNLEEAKRIGIKKAITANISMGAAFLLIYASYALAFWYGTSLV-L 327
Query: 2907 GIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAG 2728
+ G V V S+L+GA+ +G SP++ NAR +A +++ ID P ID YS G
Sbjct: 328 SREYSIGQVLTVFFSVLIGAFSIGQASPNIEAFANARGAAYEVFKIIDNKPSIDSYSNTG 387
Query: 2727 KRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTR 2548
+ N+ G ++F NVHF YPSR + KIL GLNL V G +VALVG+SGCGKST+V L+ R
Sbjct: 388 HKPDNIKGNLEFRNVHFHYPSRNEVKILKGLNLKVGSGQTVALVGNSGCGKSTTVQLMQR 447
Query: 2547 LYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIE 2368
LY+P G V+IDG D+R +N+ +LR +G+V QEP+LF TI N+ G T + + +
Sbjct: 448 LYDPTEGMVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIQK 507
Query: 2367 VCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALD 2188
K ANA+DFI K+P +DTL+G+ G QLSGGQKQR+AIAR L+R+PK+LLLDEATSAL
Sbjct: 508 AVKEANAYDFIMKLPNKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALG 567
Query: 2187 AQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRY 2008
+SE++VQ+AL+ A KGRTTI+IAHRLST+R AD I + GVIVE G+H+EL+ G Y
Sbjct: 568 TESEAVVQAALDKARKGRTTIVIAHRLSTVRNADIIAGLDDGVIVEEGSHDELMGKRGIY 627
Query: 2007 FDLVKAQQFKADPXXXXXXXXXEIDLDDT---XXXXXXXXXXXXXXXSEAFRRGNSLNDS 1837
F LV Q E++L++T + R S S
Sbjct: 628 FKLVTMQ-----------TKGNELELENTPGESLSKTDDLYMSSQDSRSSLIRRKSTRRS 676
Query: 1836 FSGSKRSXXXXXXXXXXXXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRG 1657
GS+ ++ + I K + Y +G A+I G
Sbjct: 677 IRGSQ---------SQDRKLSTEETLDESVPPVSFWRILKLNITEWPYFVVGVFCAIING 727
Query: 1656 LELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSE 1477
PA ++IF + FT + + F +G+ + + F E
Sbjct: 728 ALQPAFSVIFSRIIGIFTRNDNDETKRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGE 787
Query: 1476 NLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXX 1297
L+ R R FR++L QD S+FD+P + G L TRLA+DA +K V +R+ +
Sbjct: 788 ILTRRLRYLVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAVGSRLAVITQNIAN 847
Query: 1296 XXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQN----DDAGRIAIE 1129
IY WQ + + + ++ +++ + +++ + AG+IA E
Sbjct: 848 LGTGIIISLIYGWQ---LTLLLLAIVPIIAVAGVIEMKMLSGQALKDKKELEGAGKIATE 904
Query: 1128 IIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAV 949
IEN +T+ LTR E F Y S + R+ L++ + I +S+TQ+ MYF +
Sbjct: 905 AIENFRTVVSLTREERFEYMYAQSLQVPYRNSLRRAHVFGITFSITQAMMYFSYAGCFRF 964
Query: 948 GIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTG 769
G ++ QG D A++ GA+AV + + P++ KAK +A + NII + P
Sbjct: 965 GAYLVAQGIMEFQDVLLVFSAVVFGAMAVGQVSTFAPDYAKAKVSAAHVINIIEKIPLID 1024
Query: 768 DL-MEGDRPE-IRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTN 595
EG +P + G++ F +V F+YP RP P+++GL +GQT+ALVG SG GKST
Sbjct: 1025 SYSTEGLKPSTVEGSVAFNDVVFNYPTRPDVPVLRGLSLEVKKGQTLALVGSSGCGKSTV 1084
Query: 594 IGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG--LKD 421
+ +LERFYD G + IDG+++++L++ LR M +V QEP LF +I EN+ G +
Sbjct: 1085 VQLLERFYDPLAGTVFIDGKEVKQLNVQWLRAHMGIVSQEPILFDCSIGENIAYGDNSRV 1144
Query: 420 VPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLL 241
V E+I A + AN + F+ LP +T VG+KG QLSGGQKQRIAIARALVR P ILLL
Sbjct: 1145 VSQEEIEHAAKEANIHSFIEMLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLL 1204
Query: 240 DEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQ 61
DEATSALD+ESE+ VQEALD+AREGRTCI IAHRLS+IQN+DLIV G+++E G H Q
Sbjct: 1205 DEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRIKEHGTHQQ 1264
Query: 60 LMHQKGRYYKLIKKQ 16
L+ QKG Y+ ++ Q
Sbjct: 1265 LLAQKGIYFTMVSVQ 1279
>gi|1170902|sp|P43245|MDR1_RAT Multidrug resistance protein 1
(P-glycoprotein 1)
gi|92489|pir||JH0502 p-glycoprotein - rat
Length = 1277
Score = 797 bits (2058), Expect = 0.0
Identities = 475/1278 (37%), Positives = 719/1278 (56%), Gaps = 32/1278 (2%)
Frame = -1
Query: 3759 GDIANQQLEAQP-VSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALL 3583
G + ++ E +P V I G+FRY D L + +GT+ AII G P+L LV G +T++
Sbjct: 19 GKKSKKEKEKKPAVGIFGMFRYADWLDKLCMALGTLAAIIHGTLLPLLMLVFGYMTDSFT 78
Query: 3582 VY--PPTSKQFRNKANEN-----------------VYIFLGIGIFISITNFIQYMCFQHC 3460
P + + N++ N Y + GIG + I +IQ +
Sbjct: 79 PSRDPHSDRAITNQSEINSTHTVSDTSLEEDMAMYAYYYTGIGAGVLIVAYIQVSLWCLA 138
Query: 3459 CTRVMAQMRHRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAM 3280
R + ++R +F ++++ Q GWFD N +G + T+L D + +I +GIGDKLG+ +
Sbjct: 139 AGRQIHKIRQKFFHAIMNQEIGWFDVNDAGELNTRLTDDVSKINDGIGDKLGMFFQSITT 198
Query: 3279 LIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLM 3100
A ++ +I W+L ++L V+P + ++ A+ +TS T KEL KAG++AEE L
Sbjct: 199 FSAGFIIGFISGWKLTLVILAVSPLIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEVLA 258
Query: 3099 GVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAY 2920
+RTV AF GQ++ + RY LE+ ++ + K YG
Sbjct: 259 AIRTVIAFGGQKKELERYNKNLEEAKRVGIKKAITANISIGIAYLLVYASYALAFWYGTS 318
Query: 2919 LLKVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPY 2740
L+ + G V V S+LLG + +G ++P++ NAR +A I++ ID P ID +
Sbjct: 319 LVLSNEYSI-GQVLTVFFSILLGTFSIGHLAPNIEAFANARGAAYEIFKIIDNEPSIDSF 377
Query: 2739 SKAGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVG 2560
S G + +++G ++F+NV+F YPSR + KIL GLNL V+ G +VALVG+SGCGKST+V
Sbjct: 378 STKGHKPDSIMGNLEFKNVYFNYPSRSEVKILKGLNLKVKSGQTVALVGNSGCGKSTTVQ 437
Query: 2559 LLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRE 2380
LL RLY+P G V+IDG D+R +N+ +LR +G+V QEP+LF TI N+ G T +
Sbjct: 438 LLQRLYDPIEGEVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMD 497
Query: 2379 TMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEAT 2200
+ + K ANA+DFI K+P +DTL+G+ G QLSGGQKQR+AIAR L+R+PK+LLLDEAT
Sbjct: 498 EIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEAT 557
Query: 2199 SALDAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRL 2020
SALD +SE++VQ+AL+ A +GRTTI+IAHRLST+R AD I F+ GVIVE GNHEEL++
Sbjct: 558 SALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEELMKE 617
Query: 2019 GGRYFDLVKAQQ--FKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSL 1846
G YF LV Q + +P DT + RR S+
Sbjct: 618 KGIYFKLVMTQTRGNEIEPGNNAYESQ-----SDTGASELTSEESKSPLIRRSIRR--SI 670
Query: 1845 NDSFSGSKRSXXXXXXXXXXXXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFAL 1666
+ +R ++ + I K + Y+ +G + A+
Sbjct: 671 HRRQDQERR-------------LSSKEDVDEDVPMVSFWQILKLNISEWPYLVVGVLCAV 717
Query: 1665 IRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAV 1486
I G P A++F + F+ + + F +G+ + + F
Sbjct: 718 INGCIQPVFAIVFSKIVGVFSRDDDHETKQRNCNLFSLLFLVMGMISFVTYFFQGFTFGK 777
Query: 1485 VSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVX-- 1312
E L+ R R F+++L QD S+FD+ + G L TRLASDA N+K + +R+ V
Sbjct: 778 AGEILTKRLRYMVFKSMLRQDISWFDDHKNTTGSLTTRLASDASNVKGAMGSRLAVVTQN 837
Query: 1311 XXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQN----DDAG 1144
+Y WQ + +++G ++ L++ + +++ + +G
Sbjct: 838 VANLGTGIILSLVLVYGWQ---LTLLLVVIIPLIVLGGIIEMKLLSGQALKDKKELEISG 894
Query: 1143 RIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMC 964
+IA E IEN +T+ LTR + F Y S + R+ LKK + I ++ TQ+ +YF
Sbjct: 895 KIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNALKKAHVFGITFAFTQAMIYFSYA 954
Query: 963 FTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYR 784
+ G ++ + + ++ A++ GA+A N++ + P++ KAK +A + II +
Sbjct: 955 ACFRFGAYLVARELMTFENVMLVFSAVVFGAMAAGNTSSFAPDYAKAKVSASHIIGIIEK 1014
Query: 783 KPRTGDL-MEGDRPE-IRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGS 610
P EG +P + GN+ F VKF+YP RP P+++GL + +GQT+ LVG SG
Sbjct: 1015 IPEIDSYSTEGLKPNWLEGNVKFNGVKFNYPTRPNIPVLQGLSFEVKKGQTLRLVGSSGC 1074
Query: 609 GKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG 430
GKST + +LERFY+ G + +DG++I++L++ +R + +V QEP LF +I EN+ G
Sbjct: 1075 GKSTVVQLLERFYNPMAGTVFLDGKEIKQLNVQCVRA-LGIVSQEPILFDCSIAENIAYG 1133
Query: 429 --LKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDP 256
+ V E+I +A AN ++F+ +LP +T VG+KG QLSGGQKQRIAIARALVR P
Sbjct: 1134 DNSRVVSHEEIVRAAREANIHQFIDSLPEKYNTRVGDKGTQLSGGQKQRIAIARALVRQP 1193
Query: 255 KILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEA 76
ILLLDEATSALD+ESE+ VQEALD+AREGRTC+ IAHRLS+IQN+DLIV I G+V+E
Sbjct: 1194 HILLLDEATSALDTESEKVVQEALDKAREGRTCVVIAHRLSTIQNADLIVVIQNGQVKEH 1253
Query: 75 GNHTQLMHQKGRYYKLIK 22
G H QL+ QKG Y+ +++
Sbjct: 1254 GTHQQLLAQKGIYFSMVQ 1271
Score = 346 bits (887), Expect = 3e-93
Identities = 200/569 (35%), Positives = 322/569 (56%), Gaps = 8/569 (1%)
Frame = -1
Query: 3672 LFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKANENVY--IFLGIGIFIS 3499
L +G +CA+I+G QP+ A+V ++ V+ + N N++ +FL +G+
Sbjct: 709 LVVGVLCAVINGCIQPVFAIVFSKIVG---VFSRDDDHETKQRNCNLFSLLFLVMGMISF 765
Query: 3498 ITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFD--KNHSGTITTKLNDSMERIRE 3325
+T F Q F + ++R+ S+LRQ+ WFD KN +G++TT+L ++
Sbjct: 766 VTYFFQGFTFGKAGEILTKRLRYMVFKSMLRQDISWFDDHKNTTGSLTTRLASDASNVKG 825
Query: 3324 GIGDKLGVLLRGFAMLIAAIVVAYI--YEWRLASMMLGVAPTCCICMSLLARQMTSTTIK 3151
+G +L V+ + A L I+++ + Y W+L +++ + P + + + ++ +K
Sbjct: 826 AMGSRLAVVTQNVANLGTGIILSLVLVYGWQLTLLLVVIIPLIVLGGIIEMKLLSGQALK 885
Query: 3150 ELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXX 2971
+ + +G IA E++ RTV + +++ Y L+ + A+ K
Sbjct: 886 DKKELEISGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNALKKAHVFGITFAFT 945
Query: 2970 XXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVS 2791
+GAYL+ ++T +V +V +++ GA G S A+VS
Sbjct: 946 QAMIYFSYAACFRFGAYLVARELMTFE-NVMLVFSAVVFGAMAAGNTSSFAPDYAKAKVS 1004
Query: 2790 AASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGT 2611
A+ I I+++P+ID YS G + + G VKF V F YP+R + +L GL+ V+ G
Sbjct: 1005 ASHIIGIIEKIPEIDSYSTEGLKPNWLEGNVKFNGVKFNYPTRPNIPVLQGLSFEVKKGQ 1064
Query: 2610 SVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFN 2431
++ LVG SGCGKST V LL R Y P AG V +DG ++++LN++ +R +GIV QEPILF+
Sbjct: 1065 TLRLVGSSGCGKSTVVQLLERFYNPMAGTVFLDGKEIKQLNVQCVR-ALGIVSQEPILFD 1123
Query: 2430 DTIHNNLLIGNPGS--TRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRV 2257
+I N+ G+ + E ++ + AN H FI+ +P+ Y+T +GD G QLSGGQKQR+
Sbjct: 1124 CSIAENIAYGDNSRVVSHEEIVRAAREANIHQFIDSLPEKYNTRVGDKGTQLSGGQKQRI 1183
Query: 2256 AIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIV 2077
AIAR L+R P +LLLDEATSALD +SE +VQ AL+ A +GRT ++IAHRLSTI+ AD IV
Sbjct: 1184 AIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCVVIAHRLSTIQNADLIV 1243
Query: 2076 FFEKGVIVEAGNHEELVRLGGRYFDLVKA 1990
+ G + E G H++L+ G YF +V+A
Sbjct: 1244 VIQNGQVKEHGTHQQLLAQKGIYFSMVQA 1272
Score = 323 bits (829), Expect = 2e-86
Identities = 211/589 (35%), Positives = 309/589 (51%), Gaps = 28/589 (4%)
Frame = -1
Query: 1698 LYMFLGTVFALIRGLELPALALIFGWVFEGFTFV--PYGGRMMHR--------------- 1570
L M LGT+ A+I G LP L L+FG++ + FT P+ R +
Sbjct: 47 LCMALGTLAAIIHGTLLPLLMLVFGYMTDSFTPSRDPHSDRAITNQSEINSTHTVSDTSL 106
Query: 1569 ---MAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPA 1399
MAM + +G GV L+ + + + R + F ++ Q+ +FD
Sbjct: 107 EEDMAMYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFFHAIMNQEIGWFD--V 164
Query: 1398 HAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXL 1219
+ G+L TRL D I + ++ I W+
Sbjct: 165 NDAGELNTRLTDDVSKINDGIGDKLGMFFQSITTFSAGFIIGFISGWKLTLVILAVSP-- 222
Query: 1218 AFVMIGLAYKI------SLMNVEQIQNDDAGRIAIEIIENVKTIQLLTRCELFFDHYQTS 1057
+IGL+ + S N E AG +A E++ ++T+ + + Y +
Sbjct: 223 ---LIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKN 279
Query: 1056 SKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMML 877
++ KR +KK + I+ + +Y + G ++ + S +++L
Sbjct: 280 LEEAKRVGIKKAITANISIGIAYLLVYASYALAFWYGTSLVLSNEYSIGQVLTVFFSILL 339
Query: 876 GAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLM-EGDRPE-IRGNILFENVKFS 703
G ++ + A F A+ AA +F II +P +G +P+ I GN+ F+NV F+
Sbjct: 340 GTFSIGHLAPNIEAFANARGAAYEIFKIIDNEPSIDSFSTKGHKPDSIMGNLEFKNVYFN 399
Query: 702 YPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRK 523
YP R I+KGL GQTVALVG SG GKST + +L+R YD G + IDGQDIR
Sbjct: 400 YPSRSEVKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEGEVSIDGQDIRT 459
Query: 522 LSLFHLRTQMALVGQEPRLFAGTIRENVCLGLKDVPLEKINQALELANANRFLANLPAGI 343
+++ +LR + +V QEP LFA TI EN+ G ++V +++I +A++ ANA F+ LP
Sbjct: 460 INVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKF 519
Query: 342 DTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGR 163
DT VGE+G QLSGGQKQRIAIARALVR+PKILLLDEATSALD+ESE VQ ALD+AREGR
Sbjct: 520 DTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGR 579
Query: 162 TCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQ 16
T I IAHRLS+++N+D+I D G + E GNH +LM +KG Y+KL+ Q
Sbjct: 580 TTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEELMKEKGIYFKLVMTQ 628
>gi|6981354|ref|NP_036822.1| ATP-binding cassette, sub-family B
(MDR/TAP), member 4; ATP-binding cassette, sub-family B
(MDR/TAP), member 4 (P-glycoprotein 3/ multidrug
resistance 2); ATP-binding cassette sub-family B
(MDR/TAP) member 4 (P-glycoprotein 3/ multidrug
resistance 2); P-glycoprotein 3/ multidrug resistance 2;
ATP-binding cassette sub-family B (MDR/TAP) member 4
(P-glycoprotein 3/ multidrug resistance 2 [Rattus
norvegicus]
gi|1170903|sp|Q08201|MDR2_RAT Multidrug resistance protein 2
(P-glycoprotein 2)
gi|543425|pir||S41646 p-glycoprotein - rat
gi|310193|gb|AAA02937.1| P-glycoprotein
Length = 1278
Score = 792 bits (2045), Expect = 0.0
Identities = 481/1274 (37%), Positives = 707/1274 (54%), Gaps = 26/1274 (2%)
Frame = -1
Query: 3759 GDIANQQLEAQP-VSIPG---LFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVT- 3595
G I+NQ E + V++ G LFRY D L + +GT AI G P++ +V G +T
Sbjct: 21 GSISNQSREKKKKVNLIGPLTLFRYSDWQDKLFMLLGTAMAIAHGSGLPLMMIVFGEMTD 80
Query: 3594 -------------NALLVYPPTSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCT 3454
N L + + Y + G+G + + +IQ +
Sbjct: 81 KFVDNAGNFSLPVNFSLSMLNPGRILEEEMTRYAYYYSGLGGGVLLAAYIQVSFWTLAAG 140
Query: 3453 RVMAQMRHRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLI 3274
R + ++R +F +++LRQ GWFD + + T+L D + +I EGIGDK+G+ + A
Sbjct: 141 RQIRKIRQKFFHAILRQEMGWFDIKGTTELNTRLTDDISKISEGIGDKVGMFFQAIATFF 200
Query: 3273 AAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGV 3094
A +V +I W+L +++ + + ++ A+ +++ + KEL KAG++AEE+L +
Sbjct: 201 AGFIVGFIRGWKLTLVIMAITAILGLSTAVWAKILSTFSDKELAAYAKAGAVAEEALGAI 260
Query: 3093 RTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLL 2914
RTV AF GQ + + RY+ LE +K + K YG+ L+
Sbjct: 261 RTVIAFGGQNKELERYQKHLENAKKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLV 320
Query: 2913 KVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSK 2734
+ T G+ V S+L+GA+ +G +P + NAR +A I+ ID PKID +S+
Sbjct: 321 -ISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFPNARGAAYVIFDIIDNNPKIDSFSE 379
Query: 2733 AGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLL 2554
G + ++ G ++F +VHF YPSR + KIL GLNL V+ G +VALVG+SGCGKST+V LL
Sbjct: 380 RGHKPDSIKGNLEFSDVHFSYPSRANIKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLL 439
Query: 2553 TRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETM 2374
RLY+P G ++IDG D+R N+ LR +G+V QEP+LF+ TI N+ G T + +
Sbjct: 440 QRLYDPTEGTISIDGQDIRNFNVRCLREFIGVVSQEPVLFSTTIAENIRYGRGNVTMDEI 499
Query: 2373 IEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSA 2194
+ K ANA+DFI K+P+ +DTL+GD G QLSGGQKQR+AIAR L+R+PK+LLLDEATSA
Sbjct: 500 KKAVKEANAYDFIMKLPQKFDTLVGDRGAQLSGGQKQRIAIARALVRNPKILLLDEATSA 559
Query: 2193 LDAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGG 2014
LD +SE+ VQ+AL+ A +GRTTI+IAHRLST+R AD I FE GVIVE G+H EL++ G
Sbjct: 560 LDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELIKKEG 619
Query: 2013 RYFDLVKAQQFKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSF 1834
YF LV Q E++L D + FR NS S
Sbjct: 620 IYFRLVNMQ----TSGSQILSEEFEVELSD---EKAAGGVAPNGWKARIFR--NSTKKSL 670
Query: 1833 SGSKRSXXXXXXXXXXXXXXXXXXXEDGQI-TAGYLDIFKNAKGNYLYMFLGTVFALIRG 1657
S+ D + +L + + K + Y +GT+ A+ G
Sbjct: 671 KSSR---------AHQNRLDVETNELDANVPPVSFLKVLRLNKTEWPYFVVGTLCAIANG 721
Query: 1656 LELPALALIFGWVFEGFTFVPYGGRM-MHRMAMAVIAFASVGVGVWFSQLASSVLFAVVS 1480
PA ++I + F P + + M + F +GV +F+ F
Sbjct: 722 ALQPAFSIILSEMIA--IFGPGDDTVKQQKCNMFSLVFLGLGVHSFFTFFLQGFTFGKAG 779
Query: 1479 ENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXX 1300
E L+ R R +F+ +L QD S+FD+ ++ G L TRLA+DA ++ R+ +
Sbjct: 780 EILTTRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNTA 839
Query: 1299 XXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNV--EQIQNDDAGRIAIEI 1126
IY WQ +A I + K+ N ++ + + AG+IA E
Sbjct: 840 NLGTGIIISFIYGWQLTLLLLSVVPFIAVAGI-VEMKMLAGNAKRDKKEMEAAGKIATEA 898
Query: 1125 IENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVG 946
IEN++T+ LT+ F Y R+ ++K I I +S++Q+FMYF + G
Sbjct: 899 IENIRTVVSLTQERKFESMYVEKLHGPYRNSVRKAHIYGITFSISQAFMYFSYAGCFRFG 958
Query: 945 IRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGD 766
+I G D A++LGAVA+ +++ + P++ KAK +A LF++ R+P
Sbjct: 959 SYLIVNGHMRFKDVILVFSAIVLGAVALGHASSFAPDYAKAKLSAAYLFSLFERQPLIDS 1018
Query: 765 L-MEGDRPE-IRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNI 592
EG P+ G++ F V F+YP R P+++GL +GQT+ALVG SG GKST +
Sbjct: 1019 YSREGMWPDKFEGSVTFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVV 1078
Query: 591 GMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG--LKDV 418
+LERFYD G + +DGQ+ +KL++ LR Q+ +V QEP LF +I +N+ G + V
Sbjct: 1079 QLLERFYDPMAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAKNIAYGDNSRVV 1138
Query: 417 PLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLD 238
++I +A + AN + F+ LP +T VG+KG QLSGGQKQRIAIARAL+R P++LLLD
Sbjct: 1139 SQDEIVRAAKEANIHPFIETLPQKYETRVGDKGTQLSGGQKQRIAIARALIRQPRVLLLD 1198
Query: 237 EATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQL 58
EATSALD+ESE+ VQEALD+AREGRTCI IAHRLS+IQN+DLIV ID GKV+E G H QL
Sbjct: 1199 EATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIDNGKVKEHGTHQQL 1258
Query: 57 MHQKGRYYKLIKKQ 16
+ QKG Y+ ++ Q
Sbjct: 1259 LAQKGIYFSMVNIQ 1272
Score = 371 bits (952), Expect = e-101
Identities = 219/601 (36%), Positives = 336/601 (55%), Gaps = 9/601 (1%)
Frame = -1
Query: 3762 RGDIANQQLEAQ--PVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNA 3589
R D+ +L+A PVS + R K ++ +GT+CAI +G QP +++ ++
Sbjct: 679 RLDVETNELDANVPPVSFLKVLRLNKT-EWPYFVVGTLCAIANGALQPAFSII---LSEM 734
Query: 3588 LLVYPP---TSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVY 3418
+ ++ P T KQ K N +FLG+G+ T F+Q F + ++R
Sbjct: 735 IAIFGPGDDTVKQ--QKCNMFSLVFLGLGVHSFFTFFLQGFTFGKAGEILTTRLRSMAFK 792
Query: 3417 SVLRQNAGWFD--KNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYE 3244
++LRQ+ WFD KN +G ++T+L +++ G +L ++ + A L I++++IY
Sbjct: 793 AMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNTANLGTGIIISFIYG 852
Query: 3243 WRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQE 3064
W+L ++L V P + + + + ++ + AG IA E++ +RTV + +
Sbjct: 853 WQLTLLLLSVVPFIAVAGIVEMKMLAGNAKRDKKEMEAAGKIATEAIENIRTVVSLTQER 912
Query: 3063 EMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGD 2884
+ Y +L + +V K +G+YL+ G + D
Sbjct: 913 KFESMYVEKLHGPYRNSVRKAHIYGITFSISQAFMYFSYAGCFRFGSYLIVNGHMRFK-D 971
Query: 2883 VFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVG 2704
V +V +++LGA LG S A++SAA ++ +R P ID YS+ G G
Sbjct: 972 VILVFSAIVLGAVALGHASSFAPDYAKAKLSAAYLFSLFERQPLIDSYSREGMWPDKFEG 1031
Query: 2703 RVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGN 2524
V F V F YP+R + +L GL+L V+ G ++ALVG SGCGKST V LL R Y+P AG
Sbjct: 1032 SVTFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGT 1091
Query: 2523 VTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGS--TRETMIEVCKMAN 2350
V +DG + ++LN++WLR +GIV QEPILF+ +I N+ G+ +++ ++ K AN
Sbjct: 1092 VLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAKNIAYGDNSRVVSQDEIVRAAKEAN 1151
Query: 2349 AHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESI 2170
H FIE +P+ Y+T +GD G QLSGGQKQR+AIAR LIR P+VLLLDEATSALD +SE +
Sbjct: 1152 IHPFIETLPQKYETRVGDKGTQLSGGQKQRIAIARALIRQPRVLLLDEATSALDTESEKV 1211
Query: 2169 VQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKA 1990
VQ AL+ A +GRT I+IAHRLSTI+ AD IV + G + E G H++L+ G YF +V
Sbjct: 1212 VQEALDKAREGRTCIVIAHRLSTIQNADLIVVIDNGKVKEHGTHQQLLAQKGIYFSMVNI 1271
Query: 1989 Q 1987
Q
Sbjct: 1272 Q 1272
>gi|4505771|ref|NP_000434.1| ATP-binding cassette, subfamily B, member
4 isoform A; P glycoprotein 3/multiple drug resistance 3;
P-glycoprotein-3/multiple drug resistance-3; multiple
drug resistance 3 [Homo sapiens]
gi|126932|sp|P21439|MDR3_HUMAN Multidrug resistance protein 3
(P-glycoprotein 3)
gi|72473|pir||DVHU3 multidrug resistance protein 3 - human
gi|307181|gb|AAA36207.1| P-glycoprotein
Length = 1279
Score = 791 bits (2042), Expect = 0.0
Identities = 470/1257 (37%), Positives = 692/1257 (54%), Gaps = 21/1257 (1%)
Frame = -1
Query: 3723 VSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVT--------------NAL 3586
+ + LFRY D L + +GTI AI G P++ +V G +T N
Sbjct: 40 IGVLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFS 99
Query: 3585 LVYPPTSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLR 3406
L K + Y + G+G + + +IQ + R + ++R +F +++LR
Sbjct: 100 LSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILR 159
Query: 3405 QNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASM 3226
Q GWFD N + + T+L D + +I EGIGDK+G+ + A A +V +I W+L +
Sbjct: 160 QEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLV 219
Query: 3225 MLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRY 3046
++ ++P + ++ A+ +++ + KEL KAG++AEE+L +RTV AF GQ + + RY
Sbjct: 220 IMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERY 279
Query: 3045 EAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVM 2866
+ LE ++ + K YG+ L+ + T G+ V
Sbjct: 280 QKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLV-ISKEYTIGNAMTVFF 338
Query: 2865 SMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFEN 2686
S+L+GA+ +G +P + NAR +A I+ ID PKID +S+ G + ++ G ++F +
Sbjct: 339 SILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFND 398
Query: 2685 VHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGT 2506
VHF YPSR + KIL GLNL V+ G +VALVG SGCGKST+V L+ RLY+P+ G + IDG
Sbjct: 399 VHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQ 458
Query: 2505 DVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKM 2326
D+R N+ +LR +G+V QEP+LF+ TI N+ G T + + + K ANA++FI K+
Sbjct: 459 DIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKL 518
Query: 2325 PKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNA 2146
P+ +DTL+G+ G QLSGGQKQR+AIAR L+R+PK+LLLDEATSALD +SE+ VQ+AL+ A
Sbjct: 519 PQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKA 578
Query: 2145 SKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKADPX 1966
+GRTTI+IAHRLST+R AD I FE GVIVE G+H EL++ G YF LV Q
Sbjct: 579 REGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQ------T 632
Query: 1965 XXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXXXXXX 1786
E +L+D + N N
Sbjct: 633 SGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANV 692
Query: 1785 XXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGF 1606
+L + K K + Y +GTV A+ G PA ++IF +
Sbjct: 693 P-------------PVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIA-- 737
Query: 1605 TFVPYGGRM-MHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLY 1429
F P + + + + F +G+ +F+ F E L+ R R +F+ +L
Sbjct: 738 IFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLR 797
Query: 1428 QDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXX 1249
QD S+FD+ ++ G L TRLA+DA ++ R+ + IY WQ
Sbjct: 798 QDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLT 857
Query: 1248 XXXXXXXXXLAFVMIGLAYKISLMNVEQIQN--DDAGRIAIEIIENVKTIQLLTRCELFF 1075
+A I + K+ N ++ + + AG+IA E IEN++T+ LT+ F
Sbjct: 858 LLLLAVVPIIAVSGI-VEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFE 916
Query: 1074 DHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKG 895
Y R+ ++K I I +S++Q+FMYF + G +I G D
Sbjct: 917 SMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILV 976
Query: 894 IIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLM-EGDRPE-IRGNILF 721
A++ GAVA+ +++ + P++ KAK +A LF + R+P EG +P+ GNI F
Sbjct: 977 FSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITF 1036
Query: 720 ENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRID 541
V F+YP R P+++GL +GQT+ALVG SG GKST + +LERFYD G + +D
Sbjct: 1037 NEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLD 1096
Query: 540 GQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG--LKDVPLEKINQALELANANRF 367
GQ+ +KL++ LR Q+ +V QEP LF +I EN+ G + V ++I A + AN + F
Sbjct: 1097 GQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPF 1156
Query: 366 LANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEA 187
+ LP +T VG+KG QLSGGQKQRIAIARAL+R P+ILLLDEATSALD+ESE+ VQEA
Sbjct: 1157 IETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEA 1216
Query: 186 LDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQ 16
LD+AREGRTCI IAHRLS+IQN+DLIV G+V+E G H QL+ QKG Y+ ++ Q
Sbjct: 1217 LDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ 1273
Score = 368 bits (944), Expect = e-100
Identities = 218/618 (35%), Positives = 340/618 (54%), Gaps = 9/618 (1%)
Frame = -1
Query: 3813 KMYTPSLLEKILNYALCRG--DIANQQLEAQ--PVSIPGLFRYGKKFDYLLLFIGTICAI 3646
+++ S + + N +C+ D+ LEA PVS + + K ++ +GT+CAI
Sbjct: 661 RLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKT-EWPYFVVGTVCAI 719
Query: 3645 ISGVSQPILALVSGRVTNALLVYPPTSKQFRN-KANENVYIFLGIGIFISITNFIQYMCF 3469
+G QP +++ + + ++ P + K N IFL +GI T F+Q F
Sbjct: 720 ANGGLQPAFSVIFSEI---IAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTF 776
Query: 3468 QHCCTRVMAQMRHRFVYSVLRQNAGWFD--KNHSGTITTKLNDSMERIREGIGDKLGVLL 3295
+ ++R ++LRQ+ WFD KN +G ++T+L +++ G +L ++
Sbjct: 777 GKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIA 836
Query: 3294 RGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIA 3115
+ A L I++++IY W+L ++L V P + + + + ++ + AG IA
Sbjct: 837 QNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIA 896
Query: 3114 EESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGM 2935
E++ +RTV + + + Y +L + +V K
Sbjct: 897 TEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCF 956
Query: 2934 LYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVP 2755
+GAYL+ G + DV +V +++ GA LG S A++SAA ++ +R P
Sbjct: 957 RFGAYLIVNGHMRFR-DVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQP 1015
Query: 2754 KIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGK 2575
ID YS+ G + G + F V F YP+R + +L GL+L V+ G ++ALVG SGCGK
Sbjct: 1016 LIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGK 1075
Query: 2574 STSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNP 2395
ST V LL R Y+P AG V +DG + ++LN++WLR +GIV QEPILF+ +I N+ G+
Sbjct: 1076 STVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDN 1135
Query: 2394 GS--TRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKV 2221
+++ ++ K AN H FIE +P Y+T +GD G QLSGGQKQR+AIAR LIR P++
Sbjct: 1136 SRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQI 1195
Query: 2220 LLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGN 2041
LLLDEATSALD +SE +VQ AL+ A +GRT I+IAHRLSTI+ AD IV F+ G + E G
Sbjct: 1196 LLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGT 1255
Query: 2040 HEELVRLGGRYFDLVKAQ 1987
H++L+ G YF +V Q
Sbjct: 1256 HQQLLAQKGIYFSMVSVQ 1273
>gi|191157|gb|AAA37005.1| p-glycoprotein
Length = 1169
Score = 786 bits (2031), Expect = 0.0
Identities = 457/1191 (38%), Positives = 671/1191 (55%), Gaps = 19/1191 (1%)
Frame = -1
Query: 3531 YIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFDKNHSGTITTKL 3352
Y + GIG + I +IQ + R + ++R +F ++++ Q GWFD + G + T+L
Sbjct: 6 YYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVGELNTRL 65
Query: 3351 NDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQ 3172
D + +I EGIGDK+G+ + A ++ + W+L ++L ++P + + A+
Sbjct: 66 TDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKI 125
Query: 3171 MTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXX 2992
++S T KEL KAG++AEE L +RTV AF GQ++ + RY LE+ ++ + K
Sbjct: 126 LSSFTDKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEAKRLGIKKAITA 185
Query: 2991 XXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMV 2812
YG L+ + + G V V ++L+ + +G SP++
Sbjct: 186 NISMGAAFLLIYASYALAFWYGTSLV-ISKEYSIGQVLTVFFAVLIAPFSIGQASPNIEA 244
Query: 2811 LLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLN 2632
NAR +A I+ ID P ID +SK G + N+ G ++F+N+HF YPSRKD +IL GLN
Sbjct: 245 FANARGAAYEIFNIIDNKPSIDSFSKNGYKPDNIKGNLEFKNIHFSYPSRKDVQILKGLN 304
Query: 2631 LVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQ 2452
L V+ G +VALVG+SGCGKST+V LL RLY+P G V+IDG D+R +N+ +LR +G+V
Sbjct: 305 LKVQSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGVVSIDGQDIRTINVRYLREIIGVVS 364
Query: 2451 QEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGG 2272
QEP+LF TI N+ G T + + + K ANA+DFI K+P +DTL+G+ G QLSGG
Sbjct: 365 QEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGG 424
Query: 2271 QKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIRE 2092
QKQR+AIAR L+R+PK+LLLDEATSALD +SE++VQ+AL+ A +GRTTI+IAHRLST+R
Sbjct: 425 QKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRN 484
Query: 2091 ADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKADPXXXXXXXXXEIDLDDTXXX 1912
AD I F+ GVIVE GNHEEL+R G YF LV Q EI+L +
Sbjct: 485 ADIIAGFDGGVIVEQGNHEELMREKGIYFKLVMTQ-----------TAGNEIELGN---- 529
Query: 1911 XXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXXXXXXXXXXXXXXXEDGQITA-- 1738
E N +++ SK S +D +++
Sbjct: 530 -------------EVGESKNEIDNLDMSSKDSASSLIRRRSTRRSIRGPHDQDRKLSTKE 576
Query: 1737 ---------GYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGG 1585
+ I K + Y +G A++ G PA ++IF V FT
Sbjct: 577 ALDEDVPPISFWRILKLNSSEWPYFVVGIFCAIVNGALQPAFSIIFSKVVGVFTRNTDDE 636
Query: 1584 RMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDN 1405
H + + F +GV + + F E L+ R R F+++L QD S+FDN
Sbjct: 637 TKRHDSNLFSLLFLILGVISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDN 696
Query: 1404 PAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXX 1225
P + G L TRLA+DA +K AR+ + IY WQ
Sbjct: 697 PKNTTGALTTRLANDAGQVKGATGARLAVITQNIANLGTGIIISLIYGWQ---LTLLLLA 753
Query: 1224 XLAFVMIGLAYKISLMNVEQIQN----DDAGRIAIEIIENVKTIQLLTRCELFFDHYQTS 1057
+ + I ++ +++ + +++ + +G+IA E IEN +T+ LTR + F + Y S
Sbjct: 754 IVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFENMYAQS 813
Query: 1056 SKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMML 877
+ R+ LKK + I +S TQ+ MYF + G ++ + + ++ A++
Sbjct: 814 LQIPYRNALKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVARELMTFENVLLVFSAIVF 873
Query: 876 GAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLMEGD-RPE-IRGNILFENVKFS 703
GA+AV + + P++ KAK +A + II + P G +P + GN+ F V F+
Sbjct: 874 GAMAVGQVSSFAPDYAKAKVSASHIIMIIEKVPSIDSYSTGGLKPNTLEGNVKFNEVVFN 933
Query: 702 YPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRK 523
YP RP P+++GL +GQT+ALVG SG GKST + +LERFYD G + +DG+++ +
Sbjct: 934 YPTRPDIPVLQGLNLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEVNQ 993
Query: 522 LSLFHLRTQMALVGQEPRLFAGTIRENVCLG--LKDVPLEKINQALELANANRFLANLPA 349
L++ LR + +V QEP LF +I EN+ G + V ++I +A + AN ++F+ +LP
Sbjct: 994 LNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIERAAKEANIHQFIESLPD 1053
Query: 348 GIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRARE 169
+T VG+KG QLSGGQKQRIAIARALVR P ILLLDEATSALD+ESE+ VQEALD+ARE
Sbjct: 1054 KYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKARE 1113
Query: 168 GRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQ 16
GRTCI IAHRLS+IQN+DLIV I GKV+E G H QL+ QKG Y+ ++ Q
Sbjct: 1114 GRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQ 1164
Score = 375 bits (964), Expect = e-102
Identities = 211/566 (37%), Positives = 323/566 (56%), Gaps = 6/566 (1%)
Frame = -1
Query: 3666 IGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKANENVY--IFLGIGIFISIT 3493
+G CAI++G QP +++ +V V+ + + + N++ +FL +G+ IT
Sbjct: 603 VGIFCAIVNGALQPAFSIIFSKVVG---VFTRNTDDETKRHDSNLFSLLFLILGVISFIT 659
Query: 3492 NFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFD--KNHSGTITTKLNDSMERIREGI 3319
F+Q F + ++R+ S+LRQ+ WFD KN +G +TT+L + +++
Sbjct: 660 FFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDNPKNTTGALTTRLANDAGQVKGAT 719
Query: 3318 GDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIG 3139
G +L V+ + A L I+++ IY W+L ++L + P I + + ++ +K+
Sbjct: 720 GARLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKE 779
Query: 3138 VGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXX 2959
+ +G IA E++ RTV + +++ Y L+ + A+ K
Sbjct: 780 LEGSGKIATEAIENFRTVVSLTREQKFENMYAQSLQIPYRNALKKAHVFGITFSFTQAMM 839
Query: 2958 XXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASI 2779
+GAYL+ ++T +V +V +++ GA +G +S A+VSA+ I
Sbjct: 840 YFSYAACFRFGAYLVARELMTFE-NVLLVFSAIVFGAMAVGQVSSFAPDYAKAKVSASHI 898
Query: 2778 YQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVAL 2599
I++VP ID YS G + + G VKF V F YP+R D +L GLNL V+ G ++AL
Sbjct: 899 IMIIEKVPSIDSYSTGGLKPNTLEGNVKFNEVVFNYPTRPDIPVLQGLNLEVKKGQTLAL 958
Query: 2598 VGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIH 2419
VG SGCGKST V LL R Y+P AG V +DG +V +LN++WLR +GIV QEPILF+ +I
Sbjct: 959 VGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEVNQLNVQWLRAHLGIVSQEPILFDCSIA 1018
Query: 2418 NNLLIGNPGS--TRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIAR 2245
N+ G+ +++ + K AN H FIE +P Y+T +GD G QLSGGQKQR+AIAR
Sbjct: 1019 ENIAYGDNSRVVSQDEIERAAKEANIHQFIESLPDKYNTRVGDKGTQLSGGQKQRIAIAR 1078
Query: 2244 TLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEK 2065
L+R P +LLLDEATSALD +SE +VQ AL+ A +GRT I+IAHRLSTI+ AD IV +
Sbjct: 1079 ALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQN 1138
Query: 2064 GVIVEAGNHEELVRLGGRYFDLVKAQ 1987
G + E G H++L+ G YF +V Q
Sbjct: 1139 GKVKEHGTHQQLLAQKGIYFSMVSVQ 1164
>gi|126930|sp|P23174|MDR3_CRIGR Multidrug resistance protein 3
(P-glycoprotein 3)
gi|2119778|pir||I48123 p-glycoprotein isoform III - Chinese hamster
gi|191169|gb|AAA68885.1| p-glycoprotein isoform III
Length = 1281
Score = 785 bits (2026), Expect = 0.0
Identities = 475/1275 (37%), Positives = 707/1275 (55%), Gaps = 27/1275 (2%)
Frame = -1
Query: 3759 GDIANQ-QLEAQPVSIPG---LFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVT- 3595
G I+NQ + + + V++ G LFRY D L + +GTI AI G P++ +V G +T
Sbjct: 24 GSISNQGRNKKKKVNLIGPLTLFRYSDWQDKLFMLLGTIMAIAHGSGLPLMMIVFGEMTD 83
Query: 3594 -------------NALLVYPPTSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCT 3454
N L + + Y + G+G + + +IQ +
Sbjct: 84 KFVNNAGNFSLPVNFSLSMINPGRILEEEMTRYAYYYSGLGGGVLVAAYIQVSFWTLAAG 143
Query: 3453 RVMAQMRHRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLI 3274
R + ++R F +++LRQ GWFD + + T+L D + +I EGIGDK+G+ + A
Sbjct: 144 RQIKKIRQNFFHAILRQEMGWFDIKGTTELNTRLTDDISKISEGIGDKVGMFFQAVATFF 203
Query: 3273 AAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGV 3094
A +V +I W+L +++ ++P + ++ A+ +++ + KEL KAG++AEE+L +
Sbjct: 204 AGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSTFSDKELAAYAKAGAVAEEALGAI 263
Query: 3093 RTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLL 2914
RTV AF GQ + + RY+ LE +K + K YG+ L+
Sbjct: 264 RTVIAFGGQNKELERYQKHLENAKKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLV 323
Query: 2913 KVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSK 2734
+ T G+ V S+L+GA+ +G +P + NAR +A I+ ID PKID +S+
Sbjct: 324 -ISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSE 382
Query: 2733 AGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLL 2554
G + ++ G + F +VHF YPSR + KIL GLNL V+ G +VALVG+SGCGK+T++ LL
Sbjct: 383 RGHKPDSIKGNLDFSDVHFSYPSRANIKILKGLNLKVQSGQTVALVGNSGCGKTTTLQLL 442
Query: 2553 TRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETM 2374
RLY+P G ++IDG D+R N+ +LR +G+V QEP+LF+ TI N+ G T E +
Sbjct: 443 QRLYDPTEGTISIDGQDIRNFNVRYLREIIGVVSQEPVLFSTTIAENIRYGRGNVTMEEI 502
Query: 2373 IEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSA 2194
+ K ANA++FI K+P+ +DTL+G+ G QLSGGQKQR+AIAR L+R+PK+LLLDEATSA
Sbjct: 503 KKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSA 562
Query: 2193 LDAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGG 2014
LD +SE+ VQ+AL+ A +GRTTI+IAHRLST+R AD I FE GVIVE G+H EL++ G
Sbjct: 563 LDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMQKEG 622
Query: 2013 RYFDLVKAQQFKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSF 1834
YF LV Q E++L + S FR NS S
Sbjct: 623 VYFKLVNMQ----TSGSQILSQEFEVELSE---EKAADGMTPNGWKSHIFR--NSTKKSL 673
Query: 1833 SGSKRSXXXXXXXXXXXXXXXXXXXEDGQI-TAGYLDIFKNAKGNYLYMFLGTVFALIRG 1657
S+ D + +L + K K + Y +GTV A++ G
Sbjct: 674 KSSR---------AHHHRLDVDADELDANVPPVSFLKVLKLNKTEWPYFVVGTVCAIVNG 724
Query: 1656 LELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGV--WFSQLASSVLFAVV 1483
PA+++I E G + + + + +G+GV +F+ F
Sbjct: 725 ALQPAISIILS---EMIAIFGPGDDAVKQQKCNLFSLVFLGLGVLSFFTFFLQGFTFGKA 781
Query: 1482 SENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXX 1303
E L+ R R +F+ +L QD S+FD+ ++ G L TRLA+D ++ R+ +
Sbjct: 782 GEILTTRLRSMAFKAMLRQDMSWFDDYKNSTGALSTRLATDRAQVQGATGTRLALIAQNT 841
Query: 1302 XXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQN--DDAGRIAIE 1129
IY WQ +A I + K+ N ++ + + AG+IA E
Sbjct: 842 ANLGTGIIISFIYGWQLTLLLLSVVPFIAVSGI-VEMKMLAGNAKRDKKALEAAGKIATE 900
Query: 1128 IIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAV 949
IEN++T+ LT+ F Y + R+ ++ I I +S++Q+FMYF +
Sbjct: 901 AIENIRTVVSLTQERKFESMYVEKLHEPYRNSVQMAHIYGITFSISQAFMYFSYAGCFRF 960
Query: 948 GIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTG 769
G +I G D A++ GAVA+ +++ + P++ KAK +A LF++ R+P
Sbjct: 961 GAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFSLFERQPLID 1020
Query: 768 DLM-EGDRPE-IRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTN 595
EG P+ G++ F V F+YP R P+++GL +GQT+ALVG SG GKST
Sbjct: 1021 SYSGEGLWPDKFEGSVTFNEVVFNYPTRANMPVLQGLSLEVKKGQTLALVGSSGCGKSTV 1080
Query: 594 IGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG--LKD 421
+ +LERFYD G + +DGQ+ +KL++ LR Q+ +V QEP LF +I EN+ G +
Sbjct: 1081 VQLLERFYDPMAGTVLLDGQEAKKLNIQWLRAQLGIVSQEPVLFDCSIAENIAYGDNSRV 1140
Query: 420 VPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLL 241
V ++I +A + AN + F+ LP T VG+KG QLSGGQKQR+AI RAL+R P++LLL
Sbjct: 1141 VSQDEIVRAAKAANIHPFIETLPQKYKTRVGDKGTQLSGGQKQRLAIRRALIRQPRVLLL 1200
Query: 240 DEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQ 61
DEATSALD+ESE+ VQEALD+AREGRTCI IAHRLS+IQN+DLIV I GKV+E G H Q
Sbjct: 1201 DEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQ 1260
Query: 60 LMHQKGRYYKLIKKQ 16
L+ QKG Y+ ++ Q
Sbjct: 1261 LLAQKGIYFSMVNIQ 1275
Score = 364 bits (935), Expect = 8e-99
Identities = 213/599 (35%), Positives = 332/599 (54%), Gaps = 7/599 (1%)
Frame = -1
Query: 3762 RGDIANQQLEAQ--PVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNA 3589
R D+ +L+A PVS + + K ++ +GT+CAI++G QP ++++ ++
Sbjct: 682 RLDVDADELDANVPPVSFLKVLKLNKT-EWPYFVVGTVCAIVNGALQPAISII---LSEM 737
Query: 3588 LLVYPPTSKQFRN-KANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSV 3412
+ ++ P + K N +FLG+G+ T F+Q F + ++R ++
Sbjct: 738 IAIFGPGDDAVKQQKCNLFSLVFLGLGVLSFFTFFLQGFTFGKAGEILTTRLRSMAFKAM 797
Query: 3411 LRQNAGWFD--KNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWR 3238
LRQ+ WFD KN +G ++T+L +++ G +L ++ + A L I++++IY W+
Sbjct: 798 LRQDMSWFDDYKNSTGALSTRLATDRAQVQGATGTRLALIAQNTANLGTGIIISFIYGWQ 857
Query: 3237 LASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEM 3058
L ++L V P + + + + ++ + AG IA E++ +RTV + + +
Sbjct: 858 LTLLLLSVVPFIAVSGIVEMKMLAGNAKRDKKALEAAGKIATEAIENIRTVVSLTQERKF 917
Query: 3057 VGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVF 2878
Y +L + + +V +GAYL+ G + DV
Sbjct: 918 ESMYVEKLHEPYRNSVQMAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFR-DVI 976
Query: 2877 IVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRV 2698
+V +++ GA LG S A++SAA ++ +R P ID YS G G V
Sbjct: 977 LVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFSLFERQPLIDSYSGEGLWPDKFEGSV 1036
Query: 2697 KFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVT 2518
F V F YP+R + +L GL+L V+ G ++ALVG SGCGKST V LL R Y+P AG V
Sbjct: 1037 TFNEVVFNYPTRANMPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVL 1096
Query: 2517 IDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGS--TRETMIEVCKMANAH 2344
+DG + ++LNI+WLR +GIV QEP+LF+ +I N+ G+ +++ ++ K AN H
Sbjct: 1097 LDGQEAKKLNIQWLRAQLGIVSQEPVLFDCSIAENIAYGDNSRVVSQDEIVRAAKAANIH 1156
Query: 2343 DFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQ 2164
FIE +P+ Y T +GD G QLSGGQKQR+AI R LIR P+VLLLDEATSALD +SE +VQ
Sbjct: 1157 PFIETLPQKYKTRVGDKGTQLSGGQKQRLAIRRALIRQPRVLLLDEATSALDTESEKVVQ 1216
Query: 2163 SALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQ 1987
AL+ A +GRT I+IAHRLSTI+ AD IV + G + E G H++L+ G YF +V Q
Sbjct: 1217 EALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVNIQ 1275
>gi|9961250|ref|NP_061337.1| ATP-binding cassette, subfamily B, member
4 isoform B; P glycoprotein 3/multiple drug resistance 3;
P-glycoprotein-3/multiple drug resistance-3; multiple
drug resistance 3 [Homo sapiens]
Length = 1286
Score = 784 bits (2024), Expect = 0.0
Identities = 470/1264 (37%), Positives = 692/1264 (54%), Gaps = 28/1264 (2%)
Frame = -1
Query: 3723 VSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVT--------------NAL 3586
+ + LFRY D L + +GTI AI G P++ +V G +T N
Sbjct: 40 IGVLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFS 99
Query: 3585 LVYPPTSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLR 3406
L K + Y + G+G + + +IQ + R + ++R +F +++LR
Sbjct: 100 LSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILR 159
Query: 3405 QNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASM 3226
Q GWFD N + + T+L D + +I EGIGDK+G+ + A A +V +I W+L +
Sbjct: 160 QEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLV 219
Query: 3225 MLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRY 3046
++ ++P + ++ A+ +++ + KEL KAG++AEE+L +RTV AF GQ + + RY
Sbjct: 220 IMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERY 279
Query: 3045 EAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVM 2866
+ LE ++ + K YG+ L+ + T G+ V
Sbjct: 280 QKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLV-ISKEYTIGNAMTVFF 338
Query: 2865 SMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFEN 2686
S+L+GA+ +G +P + NAR +A I+ ID PKID +S+ G + ++ G ++F +
Sbjct: 339 SILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFND 398
Query: 2685 VHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGT 2506
VHF YPSR + KIL GLNL V+ G +VALVG SGCGKST+V L+ RLY+P+ G + IDG
Sbjct: 399 VHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQ 458
Query: 2505 DVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKM 2326
D+R N+ +LR +G+V QEP+LF+ TI N+ G T + + + K ANA++FI K+
Sbjct: 459 DIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKL 518
Query: 2325 PKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNA 2146
P+ +DTL+G+ G QLSGGQKQR+AIAR L+R+PK+LLLDEATSALD +SE+ VQ+AL+ A
Sbjct: 519 PQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKA 578
Query: 2145 SKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKADPX 1966
+GRTTI+IAHRLST+R AD I FE GVIVE G+H EL++ G YF LV Q
Sbjct: 579 REGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQ------T 632
Query: 1965 XXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXXXXXX 1786
E +L+D + N N
Sbjct: 633 SGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANV 692
Query: 1785 XXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGF 1606
+L + K K + Y +GTV A+ G PA ++IF +
Sbjct: 693 P-------------PVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIA-- 737
Query: 1605 TFVPYGGRM-MHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLY 1429
F P + + + + F +G+ +F+ F E L+ R R +F+ +L
Sbjct: 738 IFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLR 797
Query: 1428 QDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXX 1249
QD S+FD+ ++ G L TRLA+DA ++ R+ + IY WQ
Sbjct: 798 QDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLT 857
Query: 1248 XXXXXXXXXLAFVMIGLAYKISLMNVEQIQN--DDAGRIAIEIIENVKTIQLLTRCELFF 1075
+A I + K+ N ++ + + AG+IA E IEN++T+ LT+ F
Sbjct: 858 LLLLAVVPIIAVSGI-VEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFE 916
Query: 1074 DHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKG 895
Y R+ ++K I I +S++Q+FMYF + G +I G D
Sbjct: 917 SMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILV 976
Query: 894 IIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLM-EGDRPE-IRGNILF 721
A++ GAVA+ +++ + P++ KAK +A LF + R+P EG +P+ GNI F
Sbjct: 977 FSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITF 1036
Query: 720 ENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGAL--- 550
V F+YP R P+++GL +GQT+ALVG SG GKST + +LERFYD G +
Sbjct: 1037 NEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVD 1096
Query: 549 ----RIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG--LKDVPLEKINQALE 388
+DGQ+ +KL++ LR Q+ +V QEP LF +I EN+ G + V ++I A +
Sbjct: 1097 FGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAK 1156
Query: 387 LANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSES 208
AN + F+ LP +T VG+KG QLSGGQKQRIAIARAL+R P+ILLLDEATSALD+ES
Sbjct: 1157 AANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTES 1216
Query: 207 ERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKL 28
E+ VQEALD+AREGRTCI IAHRLS+IQN+DLIV G+V+E G H QL+ QKG Y+ +
Sbjct: 1217 EKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSM 1276
Query: 27 IKKQ 16
+ Q
Sbjct: 1277 VSVQ 1280
Score = 361 bits (926), Expect = 9e-98
Identities = 218/625 (34%), Positives = 340/625 (53%), Gaps = 16/625 (2%)
Frame = -1
Query: 3813 KMYTPSLLEKILNYALCRG--DIANQQLEAQ--PVSIPGLFRYGKKFDYLLLFIGTICAI 3646
+++ S + + N +C+ D+ LEA PVS + + K ++ +GT+CAI
Sbjct: 661 RLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKT-EWPYFVVGTVCAI 719
Query: 3645 ISGVSQPILALVSGRVTNALLVYPPTSKQFRN-KANENVYIFLGIGIFISITNFIQYMCF 3469
+G QP +++ + + ++ P + K N IFL +GI T F+Q F
Sbjct: 720 ANGGLQPAFSVIFSEI---IAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTF 776
Query: 3468 QHCCTRVMAQMRHRFVYSVLRQNAGWFD--KNHSGTITTKLNDSMERIREGIGDKLGVLL 3295
+ ++R ++LRQ+ WFD KN +G ++T+L +++ G +L ++
Sbjct: 777 GKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIA 836
Query: 3294 RGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIA 3115
+ A L I++++IY W+L ++L V P + + + + ++ + AG IA
Sbjct: 837 QNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIA 896
Query: 3114 EESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGM 2935
E++ +RTV + + + Y +L + +V K
Sbjct: 897 TEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCF 956
Query: 2934 LYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVP 2755
+GAYL+ G + DV +V +++ GA LG S A++SAA ++ +R P
Sbjct: 957 RFGAYLIVNGHMRFR-DVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQP 1015
Query: 2754 KIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGK 2575
ID YS+ G + G + F V F YP+R + +L GL+L V+ G ++ALVG SGCGK
Sbjct: 1016 LIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGK 1075
Query: 2574 STSVGLLTRLYEPEAGNVTID-------GTDVRELNIEWLRNTVGIVQQEPILFNDTIHN 2416
ST V LL R Y+P AG V +D G + ++LN++WLR +GIV QEPILF+ +I
Sbjct: 1076 STVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAE 1135
Query: 2415 NLLIGNPGS--TRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIART 2242
N+ G+ +++ ++ K AN H FIE +P Y+T +GD G QLSGGQKQR+AIAR
Sbjct: 1136 NIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARA 1195
Query: 2241 LIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKG 2062
LIR P++LLLDEATSALD +SE +VQ AL+ A +GRT I+IAHRLSTI+ AD IV F+ G
Sbjct: 1196 LIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNG 1255
Query: 2061 VIVEAGNHEELVRLGGRYFDLVKAQ 1987
+ E G H++L+ G YF +V Q
Sbjct: 1256 RVKEHGTHQQLLAQKGIYFSMVSVQ 1280
>gi|40644181|emb|CAC86600.1| multidrug resistance protein [Platichthys
flesus]
Length = 1292
Score = 776 bits (2005), Expect = 0.0
Identities = 446/1257 (35%), Positives = 696/1257 (54%), Gaps = 26/1257 (2%)
Frame = -1
Query: 3708 LFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYP--------------- 3574
+FR+ D ++ GT+ A+ +GV P++ +V G +T++L+ +P
Sbjct: 49 VFRFADSLDIFMILCGTVMAMANGVVLPLMCIVFGDMTDSLVNFPTGEISDNFTVIYPNF 108
Query: 3573 ---PTSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQ 3403
P + + N + +G + + ++Q + R + ++R F + +++Q
Sbjct: 109 TGLPINSTLQEDMNRYAIYYSIMGATVLVAAYLQVSLWTMAAGRQVKRIRKLFFHRIMQQ 168
Query: 3402 NAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMM 3223
+ GWFD N +G + T+L D + +I+EGIGDK +L++ + ++A V+ + W+L ++
Sbjct: 169 DIGWFDVNETGELNTRLIDDVYKIQEGIGDKAAMLIQAYTTFLSAFVIGFTKGWKLTLVI 228
Query: 3222 LGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYE 3043
L V+P + +L ++ +TS T KE KAG++AEE L +RTV AF+GQ+ + RY
Sbjct: 229 LAVSPALGLSAALFSKVLTSFTSKEQAAYAKAGAVAEEVLAAIRTVFAFSGQDREIKRYH 288
Query: 3042 AELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMS 2863
LE + + K YG+ L+ T G V V+
Sbjct: 289 KNLEDAKIMGIKKALSANISMGFTFMVIYLSYALAFWYGSTLILSNEYTI-GSVLTVLFV 347
Query: 2862 MLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENV 2683
+L+GA+ +G S ++ +AR +A +Y ID P ID YS+AG + ++ G ++F+N+
Sbjct: 348 VLIGAFTMGQSSANIQTFASARGAAHKVYSIIDNNPTIDSYSEAGFKPDSIKGNIEFKNI 407
Query: 2682 HFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTD 2503
HF YP+R D +IL ++L V+ G ++ALVG SGCGKST+V LL R Y+P+ G V +DG D
Sbjct: 408 HFSYPTRPDVQILKNMSLSVKSGQTMALVGSSGCGKSTTVQLLQRFYDPQDGAVFVDGHD 467
Query: 2502 VRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMP 2323
+R LN+ +LR +G+V QEPILF TI N+ G T + + + K ANA+DFI K+P
Sbjct: 468 IRSLNVRYLREMIGVVSQEPILFATTISENIRYGRLDVTDQEIEQAAKEANAYDFIIKLP 527
Query: 2322 KGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNAS 2143
++TL+GD G Q+SGGQKQRVAIAR L+R+PK+LLLDEATSALDA+SE+IVQ+AL+
Sbjct: 528 DKFETLVGDRGTQMSGGQKQRVAIARALVRNPKILLLDEATSALDAESETIVQAALDKVR 587
Query: 2142 KGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKADPXX 1963
GRTTI++AHRLSTIR AD I F+ G + E G H +L+ G Y LV Q F+
Sbjct: 588 LGRTTIVVAHRLSTIRNADVIAGFQDGQVAEVGTHSQLMEKKGIYQRLVTTQTFQDVEEA 647
Query: 1962 XXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXXXXXXX 1783
+D + RG+S++ S G +++
Sbjct: 648 KEAEEELSVDEKSPLADSLSECTPYRRKTT----RGSSMSASEGGKEKT----------E 693
Query: 1782 XXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFT 1603
++ +L + + + YM +GTV A+I G P A+IF + F
Sbjct: 694 SDKDETEEDENVPPVSFLKVLRLNLPEWPYMLVGTVCAIINGAMQPVFAIIFSKIITVFA 753
Query: 1602 FVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQD 1423
+ R + + FA +G + + F E L+++ R+ +F+ ++ QD
Sbjct: 754 EKDQ-ELVRQRATLFSLMFAVIGGVSFVTMFLQGFCFGKSGEILTLKLRLGAFKAMMRQD 812
Query: 1422 ASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXX 1243
S+FDNP ++ G L TRLA+DA ++ RM + IY W+
Sbjct: 813 LSWFDNPKNSVGALTTRLATDAAQVQGATGVRMATLAQNFANLGTSVIISFIYGWE--LT 870
Query: 1242 XXXXXXXLAFVMIGLAYKISLMNVEQIQN----DDAGRIAIEIIENVKTIQLLTRCELFF 1075
A V+ G A ++ L+ +++ + AG+I+ E IEN++T+ LTR F
Sbjct: 871 LLILAVVPAMVLAG-AVEMKLLTGHAVEDKKELEKAGKISTEAIENIRTVASLTREPKFE 929
Query: 1074 DHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKG 895
Y + + ++ KK + ++ +Q+ +YF + G +I +G F
Sbjct: 930 SLYHKNLEVPYKNSTKKAHVYGATFAFSQAMIYFAYAGCFRFGAWLIEEGRMDVQGVFLV 989
Query: 894 IIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDL-MEGDRPE-IRGNILF 721
I A++ GA+A+ + + P + KAK +A L ++ +P +L EG+ P+ GN+ F
Sbjct: 990 ISAVLYGAMAIGEANSFAPNYAKAKMSASHLMMLMNLEPAIDNLSQEGETPDRFDGNVHF 1049
Query: 720 ENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRID 541
ENV+F+YP RP P+++GL RG+T+ALVG SG GKST I +LERFYD G++ +D
Sbjct: 1050 ENVRFNYPSRPNLPVLQGLDLEVKRGETLALVGSSGCGKSTIIQLLERFYDPREGSVVLD 1109
Query: 540 GQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG--LKDVPLEKINQALELANANRF 367
+ ++L++ LR+QM +V QEP LF T+ +N+ G + +++I A + AN + F
Sbjct: 1110 NVNTKQLNIHWLRSQMGIVSQEPTLFDCTLAQNIAYGDNSRIATMDEIVAAAKAANIHSF 1169
Query: 366 LANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEA 187
+ LP DT G+KG QLSGGQKQRIAIARA++R+P +LLLDEATSALD+ESE+ VQEA
Sbjct: 1170 IQELPEKYDTQAGDKGTQLSGGQKQRIAIARAILRNPMLLLLDEATSALDTESEKVVQEA 1229
Query: 186 LDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQ 16
LD+A +GRTCI +AHRLS+IQN+D I + G V E G H QL+ ++G Y+ L+ Q
Sbjct: 1230 LDQASKGRTCIIVAHRLSTIQNADRIAVLQGGVVVEQGTHQQLLAKRGVYHMLVTTQ 1286
Score = 375 bits (964), Expect = e-102
Identities = 214/596 (35%), Positives = 338/596 (55%), Gaps = 6/596 (1%)
Frame = -1
Query: 3756 DIANQQLEAQPVSIPGLFRYG-KKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLV 3580
D + PVS + R ++ Y+L +GT+CAII+G QP+ A++ ++ + V
Sbjct: 697 DETEEDENVPPVSFLKVLRLNLPEWPYML--VGTVCAIINGAMQPVFAIIFSKI---ITV 751
Query: 3579 YPPTSKQF-RNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQ 3403
+ ++ R +A +F IG +T F+Q CF + ++R +++RQ
Sbjct: 752 FAEKDQELVRQRATLFSLMFAVIGGVSFVTMFLQGFCFGKSGEILTLKLRLGAFKAMMRQ 811
Query: 3402 NAGWFD--KNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLAS 3229
+ WFD KN G +TT+L +++ G ++ L + FA L ++++++IY W L
Sbjct: 812 DLSWFDNPKNSVGALTTRLATDAAQVQGATGVRMATLAQNFANLGTSVIISFIYGWELTL 871
Query: 3228 MMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGR 3049
++L V P + ++ + +T +++ + KAG I+ E++ +RTV + + +
Sbjct: 872 LILAVVPAMVLAGAVEMKLLTGHAVEDKKELEKAGKISTEAIENIRTVASLTREPKFESL 931
Query: 3048 YEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVV 2869
Y LE K + K +GA+L++ G + G VF+V+
Sbjct: 932 YHKNLEVPYKNSTKKAHVYGATFAFSQAMIYFAYAGCFRFGAWLIEEGRMDVQG-VFLVI 990
Query: 2868 MSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFE 2689
++L GA +G + A++SA+ + ++ P ID S+ G+ G V FE
Sbjct: 991 SAVLYGAMAIGEANSFAPNYAKAKMSASHLMMLMNLEPAIDNLSQEGETPDRFDGNVHFE 1050
Query: 2688 NVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDG 2509
NV F YPSR + +L GL+L V+ G ++ALVG SGCGKST + LL R Y+P G+V +D
Sbjct: 1051 NVRFNYPSRPNLPVLQGLDLEVKRGETLALVGSSGCGKSTIIQLLERFYDPREGSVVLDN 1110
Query: 2508 TDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPG--STRETMIEVCKMANAHDFI 2335
+ ++LNI WLR+ +GIV QEP LF+ T+ N+ G+ +T + ++ K AN H FI
Sbjct: 1111 VNTKQLNIHWLRSQMGIVSQEPTLFDCTLAQNIAYGDNSRIATMDEIVAAAKAANIHSFI 1170
Query: 2334 EKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSAL 2155
+++P+ YDT GD G QLSGGQKQR+AIAR ++R+P +LLLDEATSALD +SE +VQ AL
Sbjct: 1171 QELPEKYDTQAGDKGTQLSGGQKQRIAIARAILRNPMLLLLDEATSALDTESEKVVQEAL 1230
Query: 2154 NNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQ 1987
+ ASKGRT I++AHRLSTI+ AD+I + GV+VE G H++L+ G Y LV Q
Sbjct: 1231 DQASKGRTCIIVAHRLSTIQNADRIAVLQGGVVVEQGTHQQLLAKRGVYHMLVTTQ 1286
Score = 320 bits (820), Expect = 2e-85
Identities = 205/598 (34%), Positives = 309/598 (51%), Gaps = 24/598 (4%)
Frame = -1
Query: 1737 GYLDIFKNAKGNYLYMFL-GTVFALIRGLELPALALIFG-------------------WV 1618
G +D+F+ A ++M L GTV A+ G+ LP + ++FG +
Sbjct: 45 GPIDVFRFADSLDIFMILCGTVMAMANGVVLPLMCIVFGDMTDSLVNFPTGEISDNFTVI 104
Query: 1617 FEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRN 1438
+ FT +P + M I ++ +G V + L+ + + R R F
Sbjct: 105 YPNFTGLPINSTLQEDMNRYAIYYSIMGATVLVAAYLQVSLWTMAAGRQVKRIRKLFFHR 164
Query: 1437 LLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCW 1258
++ QD +FD + G+L TRL D I+ + + + W
Sbjct: 165 IMQQDIGWFD--VNETGELNTRLIDDVYKIQEGIGDKAAMLIQAYTTFLSAFVIGFTKGW 222
Query: 1257 QXXXXXXXXXXXLAFVMIGLAYKI--SLMNVEQIQNDDAGRIAIEIIENVKTIQLLTRCE 1084
+ L + L K+ S + EQ AG +A E++ ++T+ + +
Sbjct: 223 KLTLVILAVSPALG-LSAALFSKVLTSFTSKEQAAYAKAGAVAEEVLAAIRTVFAFSGQD 281
Query: 1083 LFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDT 904
Y + + K +KK + I+ T +Y + G +I + +
Sbjct: 282 REIKRYHKNLEDAKIMGIKKALSANISMGFTFMVIYLSYALAFWYGSTLILSNEYTIGSV 341
Query: 903 FKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLME-GDRPE-IRGN 730
+ +++GA + S+ F A+ AA +++II P E G +P+ I+GN
Sbjct: 342 LTVLFVVLIGAFTMGQSSANIQTFASARGAAHKVYSIIDNNPTIDSYSEAGFKPDSIKGN 401
Query: 729 ILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGAL 550
I F+N+ FSYP RP I+K + + GQT+ALVG SG GKST + +L+RFYD GA+
Sbjct: 402 IEFKNIHFSYPTRPDVQILKNMSLSVKSGQTMALVGSSGCGKSTTVQLLQRFYDPQDGAV 461
Query: 549 RIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGLKDVPLEKINQALELANANR 370
+DG DIR L++ +LR + +V QEP LFA TI EN+ G DV ++I QA + ANA
Sbjct: 462 FVDGHDIRSLNVRYLREMIGVVSQEPILFATTISENIRYGRLDVTDQEIEQAAKEANAYD 521
Query: 369 FLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQE 190
F+ LP +T VG++G Q+SGGQKQR+AIARALVR+PKILLLDEATSALD+ESE VQ
Sbjct: 522 FIIKLPDKFETLVGDRGTQMSGGQKQRVAIARALVRNPKILLLDEATSALDAESETIVQA 581
Query: 189 ALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQ 16
ALD+ R GRT I +AHRLS+I+N+D+I G+V E G H+QLM +KG Y +L+ Q
Sbjct: 582 ALDKVRLGRTTIVVAHRLSTIRNADVIAGFQDGQVAEVGTHSQLMEKKGIYQRLVTTQ 639
>gi|7511698|pir||T31073 multidrug resistance p-glycoprotein - nematode
(Haemonchus contortus)
gi|3057042|gb|AAC38987.1| P-glycoprotein [Haemonchus contortus]
Length = 1275
Score = 762 bits (1967), Expect = 0.0
Identities = 456/1278 (35%), Positives = 685/1278 (52%), Gaps = 28/1278 (2%)
Frame = -1
Query: 3759 GDIANQQLEAQPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALL- 3583
G+++ ++ E ++ G+ DY+LL GT+ + G +L +V G +T L
Sbjct: 23 GEVSKKE-EPPTITNRGILSLATTLDYVLLAAGTLAPCVHGAGFSVLGIVLGGMTTVFLR 81
Query: 3582 -----------------VYPPTSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCT 3454
+ T ++F +LG+G + T++IQ +C++
Sbjct: 82 AQNSEFVLGTVSRDPEGLPALTKEEFDTLVRRYCLYYLGLGFAMFATSYIQIVCWETFAE 141
Query: 3453 RVMAQMRHRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLI 3274
R+ ++R ++ ++LRQ WFD +G +T +L D +ER+REG+GDKL + ++ + +
Sbjct: 142 RITHKLRKIYLKAILRQQISWFDIQQTGNLTARLTDDLERVREGLGDKLSLFIQMVSAFV 201
Query: 3273 AAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGV 3094
A V + Y W + +M+ VAP I + +++ + + T E AG+IAEE+ +
Sbjct: 202 AGFCVGFAYSWSMTLVMMVVAPFIVISANWMSKIVATRTQVEQETYAVAGAIAEETFSSI 261
Query: 3093 RTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLL 2914
RTV + G + + R+EA LEKGR+ + K YG+ L+
Sbjct: 262 RTVHSICGHKRELTRFEAALEKGRQTGLVKYFYMGVGVGFGQMCTYVSYALAFWYGSVLI 321
Query: 2913 KVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSK 2734
G +F V +++ G+ LG PH+ + AR + S+ I+ PKIDPYS
Sbjct: 322 INDPALDRGRIFTVFFAVMSGSAALGTCLPHLNTISIARGAVRSVLSVINSRPKIDPYSL 381
Query: 2733 AGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLL 2554
G L N+ G ++F+NVHF YPSR+ +IL G++L V G +ALVG SGCGKST+V LL
Sbjct: 382 DGIVLNNMRGSIRFKNVHFSYPSRRTLQILKGVSLQVSAGQKIALVGSSGCGKSTNVNLL 441
Query: 2553 TRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETM 2374
R Y+P G VTID DV +LN++ LR +G+V QEP+LF+ T+ N+ +G +T E +
Sbjct: 442 LRFYDPTRGKVTIDDIDVCDLNVQKLREQIGVVSQEPVLFDGTLFENIKMGYEQATMEEV 501
Query: 2373 IEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSA 2194
E C++ANA DF +++P+GY T +G+ GVQLSGGQKQR+AIAR +I++P++LLLDEATSA
Sbjct: 502 QEACRVANAADFTKRLPEGYGTRVGERGVQLSGGQKQRIAIARAIIKNPRILLLDEATSA 561
Query: 2193 LDAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGG 2014
LD ++ESIVQ AL A KGRTT+++AHRLSTIR D+I F+ G IVE G H EL+ G
Sbjct: 562 LDTEAESIVQEALEKAQKGRTTVIVAHRLSTIRNVDQIFVFKNGTIVEQGTHAELMNKRG 621
Query: 2013 RYFDLVKAQQFKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSF 1834
+F++ +AQ + + LD S R S +
Sbjct: 622 VFFEMTQAQVLRQEKEEEV--------LDSDAESDVVSPDIALPHLSSLRSRKESTRSAI 673
Query: 1833 SG--SKRSXXXXXXXXXXXXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIR 1660
S S RS IF + + Y LG + +I
Sbjct: 674 SAVPSVRSMQIEMEDLRAKPTPMS-------------KIFYFNRDKWGYFILGLIACIIT 720
Query: 1659 GLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVS 1480
G P A+++ + + + +M + AF +G+ F+ S++
Sbjct: 721 GTVTPTFAVLYAQIIQ--VYSEPVDQMKGHVLFWCGAFIVIGLVHAFAFFFSAICLGRCG 778
Query: 1479 ENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXX 1300
E L+ + R ++F+NLL Q+ ++D+ H GKL TR A+DAPN++ V R+ V
Sbjct: 779 EALTKKLRFEAFKNLLRQNVGFYDDIRHGTGKLCTRFATDAPNVRYVF-TRLPGVLSSVV 837
Query: 1299 XXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQND-----DAGRIA 1135
I+ WQ ++IG Y M + D +AG++A
Sbjct: 838 TIIGALVIGFIFGWQLALILMVMVP----LIIGSGYFEMRMQFGKKMRDTELLEEAGKVA 893
Query: 1134 IEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTY 955
+ +EN++T+ L R E F Y K+ R L + ++ +QS ++FM +
Sbjct: 894 SQAVENIRTVHALNRQEQFHFMYCEYLKEPYRENLCQAHTYGGVFAFSQSLLFFMYAVAF 953
Query: 954 AVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPR 775
+G + D ++ A M V N + + P+ VKA+ AA +LF +I
Sbjct: 954 WIGAIFVDNHSMQPIDVYRVFFAFMFCGQMVGNISSFIPDVVKARLAASLLFYLIEHPSE 1013
Query: 774 TGDLME-GDRPEIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKST 598
+L E G +I G+I F NV F+YP R +++GL G TVALVG SG GKST
Sbjct: 1014 IDNLSEDGVTKKISGHISFRNVYFNYPTRRQIRVLRGLNLEINPGTTVALVGQSGCGKST 1073
Query: 597 NIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGLKD- 421
+ +LERFY+ G + +DG++IR +++ +LR Q+ +V QEP LF TI EN+C GL D
Sbjct: 1074 VMALLERFYNQNKGVITVDGENIRNMNIRNLREQVCIVSQEPTLFDCTIMENICYGLDDP 1133
Query: 420 -VPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILL 244
E++ A ++AN + F+ LP G DT VGEKG QLSGGQKQRIAIARAL+RDP ILL
Sbjct: 1134 KPSYEQVVAAAKMANIHNFVLGLPEGYDTRVGEKGTQLSGGQKQRIAIARALIRDPPILL 1193
Query: 243 LDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHT 64
LDEATSALD+ESE+ VQ+AL+ AR+GRTC+ IAHRLS+IQ+SD+IV I +GK + G H
Sbjct: 1194 LDEATSALDTESEKIVQDALEVARQGRTCLVIAHRLSTIQDSDVIVMIQEGKATDRGTHE 1253
Query: 63 QLMHQKGRYYKLIKKQDL 10
L+ + Y +L + Q L
Sbjct: 1254 HLLMKNDLYKRLCETQRL 1271
>gi|9961252|ref|NP_061338.1| ATP-binding cassette, subfamily B, member
4 isoform C; P glycoprotein 3/multiple drug resistance 3;
P-glycoprotein-3/multiple drug resistance-3; multiple
drug resistance 3 [Homo sapiens]
Length = 1232
Score = 749 bits (1934), Expect = 0.0
Identities = 457/1257 (36%), Positives = 674/1257 (53%), Gaps = 21/1257 (1%)
Frame = -1
Query: 3723 VSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVT--------------NAL 3586
+ + LFRY D L + +GTI AI G P++ +V G +T N
Sbjct: 40 IGVLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFS 99
Query: 3585 LVYPPTSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLR 3406
L K + Y + G+G + + +IQ + R + ++R +F +++LR
Sbjct: 100 LSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILR 159
Query: 3405 QNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASM 3226
Q GWFD N + + T+L D + +I EGIGDK+G+ + A A +V +I W+L +
Sbjct: 160 QEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLV 219
Query: 3225 MLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRY 3046
++ ++P + ++ A+ +++ + KEL KAG++AEE+L +RTV AF GQ + + RY
Sbjct: 220 IMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERY 279
Query: 3045 EAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVM 2866
+ LE ++ + K YG+ L+ + T G+ V
Sbjct: 280 QKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLV-ISKEYTIGNAMTVFF 338
Query: 2865 SMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFEN 2686
S+L+GA+ +G +P + NAR +A I+ ID PKID +S+ G + ++ G ++F +
Sbjct: 339 SILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFND 398
Query: 2685 VHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGT 2506
VHF YPSR + KIL GLNL V+ G +VALVG SGCGKST+V L+ RLY+P+ G + IDG
Sbjct: 399 VHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQ 458
Query: 2505 DVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKM 2326
D+R N+ +LR +G+V QEP+LF+ TI N+ G T + + + K ANA++FI K+
Sbjct: 459 DIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKL 518
Query: 2325 PKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNA 2146
P+ +DTL+G+ G QLSGGQKQR+AIAR L+R+PK+LLLDEATSALD +SE+ VQ+AL+ A
Sbjct: 519 PQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKA 578
Query: 2145 SKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKADPX 1966
+GRTTI+IAHRLST+R AD I FE GVIVE G+H EL++ G YF LV Q
Sbjct: 579 REGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQ------T 632
Query: 1965 XXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXXXXXX 1786
E +L+D + N N
Sbjct: 633 SGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANV 692
Query: 1785 XXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGF 1606
+L + K K + Y +GTV A+ G PA ++IF +
Sbjct: 693 P-------------PVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIA-- 737
Query: 1605 TFVPYGGRM-MHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLY 1429
F P + + + + F +G+ +F+ F E L+ R R +F+ +L
Sbjct: 738 IFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLR 797
Query: 1428 QDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXX 1249
QD S+FD+ ++ G L TRLA+DA ++ R+ + IY WQ
Sbjct: 798 QDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLT 857
Query: 1248 XXXXXXXXXLAFVMIGLAYKISLMNVEQIQN--DDAGRIAIEIIENVKTIQLLTRCELFF 1075
+A I + K+ N ++ + + AG+IA E IEN++T+ LT+ F
Sbjct: 858 LLLLAVVPIIAVSGI-VEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFE 916
Query: 1074 DHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKG 895
Y + +Y ++
Sbjct: 917 SMY----------------------------------------VEKLY-------GPYRV 929
Query: 894 IIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLM-EGDRPE-IRGNILF 721
A++ GAVA+ +++ + P++ KAK +A LF + R+P EG +P+ GNI F
Sbjct: 930 FSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITF 989
Query: 720 ENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRID 541
V F+YP R P+++GL +GQT+ALVG SG GKST + +LERFYD G + +D
Sbjct: 990 NEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLD 1049
Query: 540 GQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG--LKDVPLEKINQALELANANRF 367
GQ+ +KL++ LR Q+ +V QEP LF +I EN+ G + V ++I A + AN + F
Sbjct: 1050 GQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPF 1109
Query: 366 LANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEA 187
+ LP +T VG+KG QLSGGQKQRIAIARAL+R P+ILLLDEATSALD+ESE+ VQEA
Sbjct: 1110 IETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEA 1169
Query: 186 LDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQ 16
LD+AREGRTCI IAHRLS+IQN+DLIV G+V+E G H QL+ QKG Y+ ++ Q
Sbjct: 1170 LDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ 1226
Score = 349 bits (895), Expect = 3e-94
Identities = 214/618 (34%), Positives = 330/618 (52%), Gaps = 9/618 (1%)
Frame = -1
Query: 3813 KMYTPSLLEKILNYALCRG--DIANQQLEAQ--PVSIPGLFRYGKKFDYLLLFIGTICAI 3646
+++ S + + N +C+ D+ LEA PVS + + K ++ +GT+CAI
Sbjct: 661 RLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKT-EWPYFVVGTVCAI 719
Query: 3645 ISGVSQPILALVSGRVTNALLVYPPTSKQFRN-KANENVYIFLGIGIFISITNFIQYMCF 3469
+G QP +++ + + ++ P + K N IFL +GI T F+Q F
Sbjct: 720 ANGGLQPAFSVIFSEI---IAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTF 776
Query: 3468 QHCCTRVMAQMRHRFVYSVLRQNAGWFD--KNHSGTITTKLNDSMERIREGIGDKLGVLL 3295
+ ++R ++LRQ+ WFD KN +G ++T+L +++ G +L ++
Sbjct: 777 GKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIA 836
Query: 3294 RGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIA 3115
+ A L I++++IY W+L ++L V P + + + + ++ + AG IA
Sbjct: 837 QNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIA 896
Query: 3114 EESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGM 2935
E++ +RTV + + + Y +EK
Sbjct: 897 TEAIENIRTVVSLTQERKFESMY---VEK------------------------------- 922
Query: 2934 LYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVP 2755
LYG Y V +++ GA LG S A++SAA ++ +R P
Sbjct: 923 LYGPYR--------------VFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQP 968
Query: 2754 KIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGK 2575
ID YS+ G + G + F V F YP+R + +L GL+L V+ G ++ALVG SGCGK
Sbjct: 969 LIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGK 1028
Query: 2574 STSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNP 2395
ST V LL R Y+P AG V +DG + ++LN++WLR +GIV QEPILF+ +I N+ G+
Sbjct: 1029 STVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDN 1088
Query: 2394 GS--TRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKV 2221
+++ ++ K AN H FIE +P Y+T +GD G QLSGGQKQR+AIAR LIR P++
Sbjct: 1089 SRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQI 1148
Query: 2220 LLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGN 2041
LLLDEATSALD +SE +VQ AL+ A +GRT I+IAHRLSTI+ AD IV F+ G + E G
Sbjct: 1149 LLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGT 1208
Query: 2040 HEELVRLGGRYFDLVKAQ 1987
H++L+ G YF +V Q
Sbjct: 1209 HQQLLAQKGIYFSMVSVQ 1226
>gi|72475|pir||DVMS1A multidrug resistance protein 1a - mouse
(fragment)
gi|200330|gb|AAA03243.1| mdr1a protein
Length = 1104
Score = 746 bits (1925), Expect = 0.0
Identities = 436/1130 (38%), Positives = 645/1130 (56%), Gaps = 19/1130 (1%)
Frame = -1
Query: 3348 DSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQM 3169
D + +I EGIGDK+G+ + A ++ + W+L ++L ++P + + A+ +
Sbjct: 1 DDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKIL 60
Query: 3168 TSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXX 2989
+S T KEL KAG++AEE L +RTV AF GQ++ + RY LE+ ++ + K
Sbjct: 61 SSFTDKELHAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEAKRLGIKKAITAN 120
Query: 2988 XXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVL 2809
YG L+ + + G V V S+L+GA+ +G SP++
Sbjct: 121 ISMGAAFLLIYASYALAFWYGTSLV-ISKEYSIGQVLTVFFSVLIGAFSVGQASPNIEAF 179
Query: 2808 LNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNL 2629
NAR +A +++ ID P ID +SK+G + N+ G ++F+N+HF YPSRK+ +IL GLNL
Sbjct: 180 ANARGAAYEVFKIIDNKPSIDSFSKSGHKPDNIQGNLEFKNIHFSYPSRKEVQILKGLNL 239
Query: 2628 VVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQ 2449
V+ G +VALVG+SGCGKST+V L+ RLY+P G V+IDG D+R +N+ +LR +G+V Q
Sbjct: 240 KVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRYLREIIGVVSQ 299
Query: 2448 EPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQ 2269
EP+LF TI N+ G T + + + K ANA+DFI K+P +DTL+G+ G +SGGQ
Sbjct: 300 EPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPHQFDTLVGERGAHVSGGQ 359
Query: 2268 KQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIREA 2089
KQR+AIAR L+R+PK+LLLDEATSALD +SE++VQ+AL+ A +GRTTI+IAHRLST+R A
Sbjct: 360 KQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNA 419
Query: 2088 DKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKADPXXXXXXXXXEIDLDDTXXXX 1909
D I F+ GVIVE GNH+EL+R G YF LV Q EI+L +
Sbjct: 420 DVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQ-----------TAGNEIELGN----- 463
Query: 1908 XXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXXXXXXXXXXXXXXXEDGQIT---- 1741
EA + + +++ SK S +D +++
Sbjct: 464 ------------EACKSKDEIDNLDMSSKDSGSSLIRRRSTRKSICGPHDQDRKLSTKEA 511
Query: 1740 -------AGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGR 1582
A + I K + Y +G A+I G PA ++IF V FT
Sbjct: 512 LDEDVPPASFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFSKVVGVFTNGGPPET 571
Query: 1581 MMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNP 1402
+ + F +G+ + + F E L+ R R F+++L QD S+FD+P
Sbjct: 572 QRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDP 631
Query: 1401 AHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXX 1222
+ G L TRLA+DA +K +R+ + IY WQ
Sbjct: 632 KNTTGALTTRLANDAAQVKGATGSRLAVIFQNIANLGTGIIISLIYGWQ---LTLLLLAI 688
Query: 1221 LAFVMIGLAYKISLMNVEQIQN----DDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSS 1054
+ + I ++ +++ + +++ + +G+IA E IEN +T+ LTR + F Y S
Sbjct: 689 VPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQSL 748
Query: 1053 KQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLG 874
+ R+ +KK + I +S TQ+ MYF + G ++ Q + ++ A++ G
Sbjct: 749 QIPYRNAMKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVTQQLMTFENVLLVFSAIVFG 808
Query: 873 AVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDL-MEGDRPE-IRGNILFENVKFSY 700
A+AV + + P++ KA +A + II + P +G +P + GN+ F V F+Y
Sbjct: 809 AMAVGQVSSFAPDYAKATVSASHIIRIIEKTPEIDSYSTQGLKPNMLEGNVQFSGVVFNY 868
Query: 699 PQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKL 520
P RP P+++GL +GQT+ALVG SG GKST + +LERFYD G++ +DG++I++L
Sbjct: 869 PTRPSIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQL 928
Query: 519 SLFHLRTQMALVGQEPRLFAGTIRENVCLG--LKDVPLEKINQALELANANRFLANLPAG 346
++ LR Q+ +V QEP LF +I EN+ G + V E+I +A + AN ++F+ +LP
Sbjct: 929 NVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSYEEIVRAAKEANIHQFIDSLPDK 988
Query: 345 IDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREG 166
+T VG+KG QLSGGQKQRIAIARALVR P ILLLDEATSALD+ESE+ VQEALD+AREG
Sbjct: 989 YNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREG 1048
Query: 165 RTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQ 16
RTCI IAHRLS+IQN+DLIV I GKV+E G H QL+ QKG Y+ ++ Q
Sbjct: 1049 RTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQ 1098
Score = 372 bits (956), Expect = e-101
Identities = 210/564 (37%), Positives = 321/564 (56%), Gaps = 4/564 (0%)
Frame = -1
Query: 3666 IGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKANENVYIFLGIGIFISITNF 3487
+G CAII+G QP +++ +V P Q R +N +FL +GI IT F
Sbjct: 537 VGIFCAIINGGLQPAFSVIFSKVVGVFTNGGPPETQ-RQNSNLFSLLFLILGIISFITFF 595
Query: 3486 IQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFD--KNHSGTITTKLNDSMERIREGIGD 3313
+Q F + ++R+ S+LRQ+ WFD KN +G +TT+L + +++ G
Sbjct: 596 LQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGATGS 655
Query: 3312 KLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVG 3133
+L V+ + A L I+++ IY W+L ++L + P I + + ++ +K+ +
Sbjct: 656 RLAVIFQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELE 715
Query: 3132 KAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXX 2953
+G IA E++ RTV + +++ Y L+ + A+ K
Sbjct: 716 GSGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNAMKKAHVFGITFSFTQAMMYF 775
Query: 2952 XXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQ 2773
+GAYL+ ++T +V +V +++ GA +G +S A VSA+ I +
Sbjct: 776 SYAACFRFGAYLVTQQLMTFE-NVLLVFSAIVFGAMAVGQVSSFAPDYAKATVSASHIIR 834
Query: 2772 TIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVG 2593
I++ P+ID YS G + + G V+F V F YP+R +L GL+L V+ G ++ALVG
Sbjct: 835 IIEKTPEIDSYSTQGLKPNMLEGNVQFSGVVFNYPTRPSIPVLQGLSLEVKKGQTLALVG 894
Query: 2592 HSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNN 2413
SGCGKST V LL R Y+P AG+V +DG ++++LN++WLR +GIV QEPILF+ +I N
Sbjct: 895 SSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAQLGIVSQEPILFDCSIAEN 954
Query: 2412 LLIGNPGS--TRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTL 2239
+ G+ + E ++ K AN H FI+ +P Y+T +GD G QLSGGQKQR+AIAR L
Sbjct: 955 IAYGDNSRVVSYEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARAL 1014
Query: 2238 IRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGV 2059
+R P +LLLDEATSALD +SE +VQ AL+ A +GRT I+IAHRLSTI+ AD IV + G
Sbjct: 1015 VRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGK 1074
Query: 2058 IVEAGNHEELVRLGGRYFDLVKAQ 1987
+ E G H++L+ G YF +V Q
Sbjct: 1075 VKEHGTHQQLLAQKGIYFSMVSVQ 1098
>gi|5456701|gb|AAD43626.1| multidrug resistance protein MDR
[Emericella nidulans]
gi|6856159|gb|AAF29805.1| ABC-transporter [Emericella nidulans]
Length = 1348
Score = 738 bits (1904), Expect = 0.0
Identities = 442/1274 (34%), Positives = 679/1274 (52%), Gaps = 26/1274 (2%)
Frame = -1
Query: 3753 IANQQLEAQPVSIP--GLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNA--- 3589
+ QLE V+I GL+RY K D L++ I TICAI +G + P+ ++ G + +
Sbjct: 88 VLKTQLEEIKVNISFFGLWRYATKMDILIMVISTICAIAAGAALPLFTILFGSLASTFQR 147
Query: 3588 LLVYPPTSKQFRNKANENV--YIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYS 3415
+++Y + +F ++ +NV +++LGIG F+++ ++ + F + ++R ++ S
Sbjct: 148 IMLYQISYDEFYDELTKNVLYFVYLGIGEFVTV--YVSTVGFIYTGEHATQKIREYYLES 205
Query: 3414 VLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRL 3235
+LRQN G+FDK +G +TT++ I++GI +K+G+ L A + A ++AY+ W+L
Sbjct: 206 ILRQNIGYFDKLGAGEVTTRITADTNLIQDGISEKVGLTLTALATFVTAFIIAYVKYWKL 265
Query: 3234 ASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMV 3055
A + + M ++ + + K L G G++AEE + +R AF Q+++
Sbjct: 266 ALICSSTIVALVLTMGGGSQFIIKYSKKSLDSYGAGGTVAEEVISSIRNATAFGTQDKLA 325
Query: 3054 GRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFI 2875
+YE L++ K+ G G G+ L G + GD+
Sbjct: 326 KQYEVHLDEAEKWGTKNQIVMGFMIGAMFGLMYSNYGLGFWMGSRFLVDGAVDV-GDILT 384
Query: 2874 VVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVK 2695
V+M++L+G++ LG +SP+ NA +AA I+ TIDR +DPYS GK L + G ++
Sbjct: 385 VLMAILIGSFSLGNVSPNAQAFTNAVAAAAKIFGTIDRQSPLDPYSNEGKTLDHFEGHIE 444
Query: 2694 FENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTI 2515
NV YPSR + ++ ++L + G + ALVG SG GKST VGL+ R Y P G V +
Sbjct: 445 LRNVKHIYPSRPEVTVMEDVSLSMPAGKTTALVGPSGSGKSTVVGLVERFYMPVRGTVLL 504
Query: 2514 DGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGS---------TRETMIEVC 2362
DG D+++LN+ WLR + +V QEP+LF TI+ N+ G G+ RE +
Sbjct: 505 DGHDIKDLNLRWLRQQISLVSQEPVLFGTTIYKNIRHGLIGTKYENESEDKVRELIENAA 564
Query: 2361 KMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQ 2182
KMANAHDFI +P+GY+T +G G LSGGQKQR+AIAR ++ DPK+LLLDEATSALD +
Sbjct: 565 KMANAHDFITALPEGYETNVGQRGFLLSGGQKQRIAIARAVVSDPKILLLDEATSALDTK 624
Query: 2181 SESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFD 2002
SE +VQ+AL A++GRTTI+IAHRLSTI+ A IV G I E G H+ELV GG Y
Sbjct: 625 SEGVVQAALERAAEGRTTIVIAHRLSTIKTAHNIVVLVNGKIAEQGTHDELVDRGGAYRK 684
Query: 2001 LVKAQQFKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSK 1822
LV+AQ+ DL + + +S + G
Sbjct: 685 LVEAQRINEQKEADALEDADAEDLTNADIA--------------KIKTASSASSDLDGKP 730
Query: 1821 RSXXXXXXXXXXXXXXXXXXXEDGQITAGYLDIFKNA----KGNYLYMFLGTVFALIRGL 1654
+ + + K + YM +G VF+++ G
Sbjct: 731 TTIDRTGTHKSVSSAILSKRPPETTPKYSLWTLLKFVASFNRPEIPYMLIGLVFSVLAGG 790
Query: 1653 ELPALALIFGWVFEGFTF-VPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSE 1477
P A+++ + ++ H + F VG+ + +Q + FAV SE
Sbjct: 791 GQPTQAVLYAKAISTLSLPESQYSKLRHDADFWSLMFFVVGIIQFITQSTNGAAFAVCSE 850
Query: 1476 NLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXX 1297
L R R +FR +L QD ++FD ++ G L + L+++ ++ V + +
Sbjct: 851 RLIRRARSTAFRTILRQDIAFFDKEENSTGALTSFLSTETKHLSGVSGVTLGTILMTSTT 910
Query: 1296 XXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKIS-LMNVEQIQNDDAGRIAIEIIE 1120
W+ L Y ++ + ++ + + A E
Sbjct: 911 LGAAIIIALAIGWKLALVCISVVPVLLACGFYRFYMLAQFQSRSKLAYEGSANFACEATS 970
Query: 1119 NVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIR 940
+++T+ LTR ++ Y Q R+ L + ++ Y+ +Q+ ++F + + G
Sbjct: 971 SIRTVASLTRERDVWEIYHAQLDAQGRTSLISVLRSSLLYASSQALVFFCVALGFWYGGT 1030
Query: 939 IIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLM 760
++ + F ++ GA + + P+ KAK AA + RKP+ +
Sbjct: 1031 LLGHHEYDIFRFFVCFSEILFGAQSAGTVFSFAPDMGKAKNAAAEFRRLFDRKPQIDNWS 1090
Query: 759 -EGDRPE-IRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGM 586
EG++ E + G I F NV F YP RP QP+++GL T GQ VALVGPSG GKST I +
Sbjct: 1091 EEGEKLETVEGEIEFRNVHFRYPTRPEQPVLRGLDLTVKPGQYVALVGPSGCGKSTTIAL 1150
Query: 585 LERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGL--KDVPL 412
LERFYD G++ +DG+DI KL++ R+ ++LV QEP L+ GTI+EN+ LG+ DVP
Sbjct: 1151 LERFYDAIAGSILVDGKDISKLNINSYRSFLSLVSQEPTLYQGTIKENILLGIVEDDVPE 1210
Query: 411 EKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEA 232
E + +A + AN F+ +LP G +T VG KGG LSGGQKQR+AIARAL+RDPKILLLDEA
Sbjct: 1211 EFLIKACKDANIYDFIMSLPEGFNTVVGSKGGMLSGGQKQRVAIARALLRDPKILLLDEA 1270
Query: 231 TSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMH 52
TSALDSESE+ VQ ALD A GRT I +AHRLS+IQ +D+I D+GK+ E+G H++L+
Sbjct: 1271 TSALDSESEKVVQAALDAAARGRTTIAVAHRLSTIQKADVIYVFDQGKIVESGTHSELVQ 1330
Query: 51 QKGRYYKLIKKQDL 10
+KGRYY+L+ Q L
Sbjct: 1331 KKGRYYELVNLQSL 1344
>gi|45361353|ref|NP_989254.1| hypothetical protein MGC76216 [Xenopus
tropicalis]
gi|39645391|gb|AAH63924.1| Hypothetical protein MGC76216 [Xenopus
tropicalis]
Length = 1261
Score = 735 bits (1897), Expect = 0.0
Identities = 434/1253 (34%), Positives = 669/1253 (52%), Gaps = 16/1253 (1%)
Frame = -1
Query: 3726 PVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTS------ 3565
P+SI F++ D L+ IGT+ AI G P++ +V G ++++ L + +
Sbjct: 39 PISI---FQFADWLDIFLMIIGTLGAIGCGSCYPLMNVVFGEMSDSFLCHNSSLQNSSAC 95
Query: 3564 ---KQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAG 3394
K + + + G+G + ++Q C+ +R +MR F +SVL Q G
Sbjct: 96 AKFKPIEEEIQKFSLYYAGLGFAVLFCGYLQVSCWVVAASRQTRKMRKAFFHSVLSQEIG 155
Query: 3393 WFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGV 3214
WFD SG + T+L +++ +I +GIGDK+ + + ++ I++ I W+LA ++L
Sbjct: 156 WFDVTKSGDLNTRLTENINKINDGIGDKVAHFFQNTTICVSGILIGLIQGWKLALVILAT 215
Query: 3213 APTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAEL 3034
+P + ++ +R + S T KEL KAG++A+E L +RTV AF G+E+ + RY L
Sbjct: 216 SPVLTLASAMFSRIVVSLTTKELAAYAKAGAVAQEVLSSIRTVVAFGGEEKEIKRYTENL 275
Query: 3033 EKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLL 2854
++ + + K G G YG L+ T GDV V ++
Sbjct: 276 KQAKDIGIKKSIASQFALGLVNGAFYATYGVGFWYGTTLVLEDDDYTIGDVMAVFFNVSF 335
Query: 2853 GAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFR 2674
+Y +G + H AR +A+SI++ I + ID +S G + N+ G ++ ++++F
Sbjct: 336 SSYAIGQAASHFEAFHIARAAASSIFKVIKQSSSIDNFSNDGFKPDNIKGNIELKDIYFS 395
Query: 2673 YPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRE 2494
YPSR K+LNGLNL V+ G +VALVG SGCGKST V LL RLY+P+ G + +DG D++
Sbjct: 396 YPSRPGVKVLNGLNLSVKSGQTVALVGQSGCGKSTIVQLLQRLYDPKEGTLAVDGHDIKS 455
Query: 2493 LNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGY 2314
LN+ + R +G+V QEP+LF TI N+ G T E + + K ANA+DFI +P Y
Sbjct: 456 LNVTYYRELIGVVSQEPVLFGTTIKQNIRYGRDDVTDEEIEKAVKEANAYDFIMALPDKY 515
Query: 2313 DTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGR 2134
+TL+G+ G QLSGGQKQR+A+AR L+R+PK+LLLDEATSALD SE++VQ+AL+ A KGR
Sbjct: 516 ETLVGERGAQLSGGQKQRIAVARALVRNPKILLLDEATSALDTGSEAVVQAALDKARKGR 575
Query: 2133 TTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKADPXXXXX 1954
TTI++AHRLSTI AD IV + G + E G H EL+ G YF L AQ +
Sbjct: 576 TTIVVAHRLSTIWTADVIVVIDNGAVAEQGTHSELMEKKGIYFSLATAQTVQLS------ 629
Query: 1953 XXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXXXXXXXXXX 1774
D ++T + F SL +
Sbjct: 630 ------DDNETTEKNQNGIIYEKASLIQRFNSQTSLKSKILEDEDEEEESKKDLP----- 678
Query: 1773 XXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVP 1594
T + + K + + Y+ LG + A + G LP + + + F
Sbjct: 679 ----------TVSFFQLLKLNRSEWPYILLGIIAAGVIGSLLPLFCIFYARIIAVFASND 728
Query: 1593 YGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASY 1414
+ + + F GV + + +A +F E L+MR R +F+ ++ QD ++
Sbjct: 729 -PETIRKESDLCSLIFGLTGVVILLAYIARGYMFGRSGETLTMRLRHMAFKAMIQQDIAW 787
Query: 1413 FDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXX 1234
FD+ + G L TRLA+DA I+ R+ + +Y W+
Sbjct: 788 FDDKDNNTGALTTRLATDASEIQTATGYRLGFLAENLIGIVLTVIIAFVYGWELALLGLA 847
Query: 1233 XXXXLAFVMIGLAYKISLMNV---EQIQNDDAGRIAIEIIENVKTIQLLTRCELFFDHYQ 1063
V+ GL +L ++ Q AG+IA E ++N++T+ LTR F + Y
Sbjct: 848 MAPF--MVICGLLEFSALTGFATRDKKQLQRAGKIATEAVDNIRTLVSLTRERTFEEMYS 905
Query: 1062 TSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAM 883
S ++ R+ L+K I + +++ +F YF + G +I + ++ +
Sbjct: 906 ESLQKPYRNSLRKAQIYGLYFAIGHAFYYFTHAALFCFGAYLIKYERINVEEALLVFSVI 965
Query: 882 MLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPR-TGDLMEGDRPE-IRGNILFENVK 709
GA+ + + + P++ KA +AA LF + KP +G +P+ G++ F NV
Sbjct: 966 TFGAMTLGTTLTFAPDYAKATSAARYLFALFESKPAIDSSSQQGQKPDCFSGSLEFRNVS 1025
Query: 708 FSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDI 529
F+YP R +++ L GQTVA VG SG GKST++ +L+RFYD G + +D D
Sbjct: 1026 FNYPTRSDVRVLRDLCVKVESGQTVAFVGSSGCGKSTSVQLLQRFYDPKEGEVLLDDVDA 1085
Query: 528 RKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG--LKDVPLEKINQALELANANRFLANL 355
+ ++ LR+QM +V QEP LF +I EN+ G + V +++I A + AN + F+ L
Sbjct: 1086 KCFNVQWLRSQMGIVSQEPVLFDCSIAENIAYGDNSRTVSMDEIQSAAKAANIHSFIEGL 1145
Query: 354 PAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRA 175
P +T VG KG QLSGGQKQRIAIARAL+R PKILLLDEATSALD+ESE+ VQ+ALD+A
Sbjct: 1146 PLKYETLVGAKGTQLSGGQKQRIAIARALIRAPKILLLDEATSALDNESEKVVQQALDQA 1205
Query: 174 REGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQ 16
R+GRTCI IAHRL+++QN+D+IV ++KGK+ E G+H +L+ + G YY L+ Q
Sbjct: 1206 RKGRTCILIAHRLTTVQNADIIVVMNKGKIIEHGSHQELLAKCGAYYDLVNAQ 1258
>gi|49089458|ref|XP_406437.1| hypothetical protein AN2300.2
[Aspergillus nidulans FGSC A4]
gi|40745255|gb|EAA64411.1| hypothetical protein AN2300.2 [Aspergillus
nidulans FGSC A4]
Length = 1343
Score = 734 bits (1895), Expect = 0.0
Identities = 442/1271 (34%), Positives = 675/1271 (52%), Gaps = 23/1271 (1%)
Frame = -1
Query: 3753 IANQQLEAQPVSIP--GLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLV 3580
+ QLE V+I GL+RY K D L++ I TICAI +G + P+ S +++
Sbjct: 88 VLKTQLEEIKVNISFFGLWRYATKMDILIMVISTICAIAAGAALPLFTAPS--TFQRIML 145
Query: 3579 YPPTSKQFRNKANENV--YIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLR 3406
Y + +F ++ +NV +++LGIG F+++ ++ + F + ++R ++ S+LR
Sbjct: 146 YQISYDEFYDELTKNVLYFVYLGIGEFVTV--YVSTVGFIYTGEHATQKIREYYLESILR 203
Query: 3405 QNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASM 3226
QN G+FDK +G +TT++ I++GI +K+G+ L A + A ++AY+ W+LA +
Sbjct: 204 QNIGYFDKLGAGEVTTRITADTNLIQDGISEKVGLTLTALATFVTAFIIAYVKYWKLALI 263
Query: 3225 MLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRY 3046
+ M ++ + + K L G G++AEE + +R AF Q+++ +Y
Sbjct: 264 CSSTIVALVLTMGGGSQFIIKYSKKSLDSYGAGGTVAEEVISSIRNATAFGTQDKLAKQY 323
Query: 3045 EAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVM 2866
E L++ K+ G G G+ L G + GD+ V+M
Sbjct: 324 EVHLDEAEKWGTKNQIVMGFMIGAMFGLMYSNYGLGFWMGSRFLVDGAVDV-GDILTVLM 382
Query: 2865 SMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFEN 2686
++L+G++ LG +SP+ NA +AA I+ TIDR +DPYS GK L + G ++ N
Sbjct: 383 AILIGSFSLGNVSPNAQAFTNAVAAAAKIFGTIDRQSPLDPYSNEGKTLDHFEGHIELRN 442
Query: 2685 VHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGT 2506
V YPSR + ++ ++L + G + ALVG SG GKST VGL+ R Y P G V +DG
Sbjct: 443 VKHIYPSRPEVTVMEDVSLSMPAGKTTALVGPSGSGKSTVVGLVERFYMPVRGTVLLDGH 502
Query: 2505 DVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGS---------TRETMIEVCKMA 2353
D+++LN+ WLR + +V QEP+LF TI+ N+ G G+ RE + KMA
Sbjct: 503 DIKDLNLRWLRQQISLVSQEPVLFGTTIYKNIRHGLIGTKYENESEDKVRELIENAAKMA 562
Query: 2352 NAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSES 2173
NAHDFI +P+GY+T +G G LSGGQKQR+AIAR ++ DPK+LLLDEATSALD +SE
Sbjct: 563 NAHDFITALPEGYETNVGQRGFLLSGGQKQRIAIARAVVSDPKILLLDEATSALDTKSEG 622
Query: 2172 IVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVK 1993
+VQ+AL A++GRTTI+IAHRLSTI+ A IV G I E G H+ELV GG Y LV+
Sbjct: 623 VVQAALERAAEGRTTIVIAHRLSTIKTAHNIVVLVNGKIAEQGTHDELVDRGGAYRKLVE 682
Query: 1992 AQQFKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSX 1813
AQ+ DL + + +S + G +
Sbjct: 683 AQRINEQKEADALEDADAEDLTNADIA--------------KIKTASSASSDLDGKPTTI 728
Query: 1812 XXXXXXXXXXXXXXXXXXEDGQITAGYLDIFKNA----KGNYLYMFLGTVFALIRGLELP 1645
+ + K + YM +G VF+++ G P
Sbjct: 729 DRTGTHKSVSSAILSKRPPETTPKYSLWTLLKFVASFNRPEIPYMLIGLVFSVLAGGGQP 788
Query: 1644 ALALIFGWVFEGFTF-VPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLS 1468
A+++ + ++ H + F VG+ + +Q + FAV SE L
Sbjct: 789 TQAVLYAKAISTLSLPESQYSKLRHDADFWSLMFFVVGIIQFITQSTNGAAFAVCSERLI 848
Query: 1467 MRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXX 1288
R R +FR +L QD ++FD ++ G L + L+++ ++ V + +
Sbjct: 849 RRARSTAFRTILRQDIAFFDKEENSTGALTSFLSTETKHLSGVSGVTLGTILMTSTTLGA 908
Query: 1287 XXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKIS-LMNVEQIQNDDAGRIAIEIIENVK 1111
W+ L Y ++ + ++ + + A E +++
Sbjct: 909 AIIIALAIGWKLALVCISVVPVLLACGFYRFYMLAQFQSRSKLAYEGSANFACEATSSIR 968
Query: 1110 TIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIY 931
T+ LTR ++ Y Q R+ L + ++ Y+ +Q+ ++F + + G ++
Sbjct: 969 TVASLTRERDVWEIYHAQLDAQGRTSLISVLRSSLLYASSQALVFFCVALGFWYGGTLLG 1028
Query: 930 QGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLM-EG 754
+ F ++ GA + + P+ KAK AA + RKP+ + EG
Sbjct: 1029 HHEYDIFRFFVCFSEILFGAQSAGTVFSFAPDMGKAKNAAAEFRRLFDRKPQIDNWSEEG 1088
Query: 753 DRPE-IRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLER 577
++ E + G I F NV F YP RP QP+++GL T GQ VALVGPSG GKST I +LER
Sbjct: 1089 EKLETVEGEIEFRNVHFRYPTRPEQPVLRGLDLTVKPGQYVALVGPSGCGKSTTIALLER 1148
Query: 576 FYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGL--KDVPLEKI 403
FYD G++ +DG+DI KL++ R+ ++LV QEP L+ GTI+EN+ LG+ DVP E +
Sbjct: 1149 FYDAIAGSILVDGKDISKLNINSYRSFLSLVSQEPTLYQGTIKENILLGIVEDDVPEEFL 1208
Query: 402 NQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSA 223
+A + AN F+ +LP G +T VG KGG LSGGQKQR+AIARAL+RDPKILLLDEATSA
Sbjct: 1209 IKACKDANIYDFIMSLPEGFNTVVGSKGGMLSGGQKQRVAIARALLRDPKILLLDEATSA 1268
Query: 222 LDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKG 43
LDSESE+ VQ ALD A GRT I +AHRLS+IQ +D+I D+GK+ E+G H++L+ +KG
Sbjct: 1269 LDSESEKVVQAALDAAARGRTTIAVAHRLSTIQKADVIYVFDQGKIVESGTHSELVQKKG 1328
Query: 42 RYYKLIKKQDL 10
RYY+L+ Q L
Sbjct: 1329 RYYELVNLQSL 1339
>gi|27656757|gb|AAO20901.1| Mdr3 [Takifugu rubripes]
Length = 1292
Score = 734 bits (1894), Expect = 0.0
Identities = 441/1287 (34%), Positives = 682/1287 (52%), Gaps = 56/1287 (4%)
Frame = -1
Query: 3708 LFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLV----------YPPTSKQ 3559
LFR+ ++D +LL GT+ A+++G P++ +V G +T++ + + T+
Sbjct: 47 LFRFADRWDVVLLISGTVMAMVNGTVMPLMCIVFGEMTDSFIYADMAQHNASGWNSTTTI 106
Query: 3558 FRNKANENVYIFL----GIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGW 3391
+ E++ F +G + + ++Q + R + ++R F + +++Q W
Sbjct: 107 LNSTLQEDMQRFAIYYSVLGFVVLLAAYMQVSFWTITAGRQVKRIRSLFFHCIMQQEISW 166
Query: 3390 FDKNHSGTITTKLND------------------------------SMERIREGIGDKLGV 3301
FD N +G + T+L + + +I+EGIGDK+G+
Sbjct: 167 FDVNDTGELNTRLTEEFPASAFTLCTATLGGVDDLMDVLLFSNGSDVYKIQEGIGDKVGL 226
Query: 3300 LLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGS 3121
L++ + I A ++ + W+L ++L V+P I + ++ + S T KE KAG+
Sbjct: 227 LIQAYTTFITAFIIGFTTGWKLTLVILAVSPALAISAAFFSKVLASFTSKEQTAYAKAGA 286
Query: 3120 IAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGC 2941
+AEE L +RTV AF+GQ + RY L + V K
Sbjct: 287 VAEEVLSAIRTVFAFSGQTREIERYHKNLRDAKDVGVKKAISSNIAMGFTFLMIYLSYAL 346
Query: 2940 GMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDR 2761
YG+ L+ + T G++ V +L+GA+ +G SP++ +AR +A +Y ID
Sbjct: 347 AFWYGSTLI-LNFEYTIGNLLTVFFVVLIGAFSVGQTSPNIQNFASARGAAYKVYSIIDN 405
Query: 2760 VPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGC 2581
P ID +S+ G + + G ++F+N+HF YPSR + KILN ++L V+ G ++ALVG SGC
Sbjct: 406 KPNIDSFSEDGFKPDFIKGDIEFKNIHFNYPSRPEVKILNNMSLSVKSGQTIALVGSSGC 465
Query: 2580 GKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIG 2401
GKST++ LL R Y+PE G V IDG D+R LNI +LR +G+V QEP+LF TI N+ G
Sbjct: 466 GKSTTIQLLQRFYDPEEGAVFIDGHDIRSLNIRYLREMIGVVSQEPVLFATTITENIRYG 525
Query: 2400 NPGSTRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKV 2221
T+E + K +NA+DFI +P ++TL+GD G QLSGGQKQR+AIAR L+R+PK+
Sbjct: 526 RLDVTQEEIERATKESNAYDFIMNLPDKFETLVGDRGTQLSGGQKQRIAIARALVRNPKI 585
Query: 2220 LLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGN 2041
LLLDEATSALDA+SE+IVQ+AL+ GRTTI++AHRLSTIR AD I F G IVE G
Sbjct: 586 LLLDEATSALDAESETIVQAALDKVRLGRTTIVVAHRLSTIRNADIIAGFSNGKIVEQGT 645
Query: 2040 HEELVRLGGRYFDLVKAQQFKADPXXXXXXXXXEIDLDDTXXXXXXXXXXX----XXXXS 1873
H +L+ + G Y LV Q F ++ ++T S
Sbjct: 646 HSQLMEIKGVYHGLVTMQTF------------HNVEEENTAMSELSAGEKSPVEKTVSQS 693
Query: 1872 EAFRRGNSLNDSFSGSKRSXXXXXXXXXXXXXXXXXXXEDGQITAGYLDIFKNAKGNYLY 1693
RR ++ SF+ S+ ++ + + + Y
Sbjct: 694 SIIRRKSTRGSSFAASE------------GTKEEKTEEDEDVPDVSFFKVLHLNIPEWPY 741
Query: 1692 MFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQ 1513
+ +G + A I G P A++F + F P + + + F +G + +
Sbjct: 742 ILVGLICATINGAMQPVFAILFSKIITVFA-DPDRDSVRRKSEFISLMFVVIGCVSFVTM 800
Query: 1512 LASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVD 1333
F E L+++ R+++F ++ QD S++DNP + G L TRLA+DA ++
Sbjct: 801 FLQGYCFGKSGEILTLKLRLRAFTAMMRQDLSWYDNPQNTVGALTTRLAADAAQVQGAAG 860
Query: 1332 ARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLM----NVEQ 1165
R+ + +Y W+ + + A +I L+ ++
Sbjct: 861 VRLATIMQNFANLGTSIIIAFVYGWE---LTLLILAVVPLIAAAGAAEIKLLAGHAAKDK 917
Query: 1164 IQNDDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQS 985
+ + AG+IA E IENV+T+ L+R F Y+ + + ++ KK + + YS +Q+
Sbjct: 918 KELEKAGKIATEAIENVRTVVSLSREPKFECLYEENLRVPYKNSQKKAHVYGLTYSFSQA 977
Query: 984 FMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGM 805
+YF + G +I G + F + A++ GA+AV + + P + KAK AA
Sbjct: 978 MIYFAYAACFRFGAWLIEAGRMDVEGVFLVVSAVLYGAMAVGEANTFAPNYAKAKMAASY 1037
Query: 804 LFNIIYRKPRTGDLM-EGDRPE-IRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVA 631
L +I +KP +L EG PE GN+ FE VKF+YP RP I++GL +G+T+A
Sbjct: 1038 LMMLINKKPAIDNLSEEGTSPEKYDGNVHFEGVKFNYPSRPDVTILQGLNLKVKKGETLA 1097
Query: 630 LVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTI 451
LVG SG GKST I +LERFYD G + +DG ++++L++ LR+Q+ +V QEP LF ++
Sbjct: 1098 LVGSSGCGKSTTIQLLERFYDPREGRVSLDGVNVKQLNIHWLRSQIGIVSQEPVLFDCSL 1157
Query: 450 RENVCLG--LKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIA 277
EN+ G + V +++I DT G+KG QLSGGQKQR+AIA
Sbjct: 1158 AENIAYGDNSRSVSMDEIR------------------YDTQAGDKGTQLSGGQKQRVAIA 1199
Query: 276 RALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYID 97
RA++R+PK+LLLDEATSALD+ESE+ VQEALD+AR+GRTCI +AHRLS+IQN+D I
Sbjct: 1200 RAIIRNPKLLLLDEATSALDTESEKVVQEALDQARKGRTCIVVAHRLSTIQNADCIAVFQ 1259
Query: 96 KGKVQEAGNHTQLMHQKGRYYKLIKKQ 16
G V E G H QL+ +KG Y+ L+ KQ
Sbjct: 1260 GGVVVEKGTHQQLIAKKGVYHMLVTKQ 1286
Score = 296 bits (758), Expect = 3e-78
Identities = 205/627 (32%), Positives = 317/627 (49%), Gaps = 53/627 (8%)
Frame = -1
Query: 1737 GYLDIFKNA-KGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVP----------- 1594
G + +F+ A + + + + GTV A++ G +P + ++FG + + F +
Sbjct: 43 GPITLFRFADRWDVVLLISGTVMAMVNGTVMPLMCIVFGEMTDSFIYADMAQHNASGWNS 102
Query: 1593 ----YGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQ 1426
+ M I ++ +G V + + + + R R F ++ Q
Sbjct: 103 TTTILNSTLQEDMQRFAIYYSVLGFVVLLAAYMQVSFWTITAGRQVKRIRSLFFHCIMQQ 162
Query: 1425 DASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXX 1246
+ S+FD + G+L TRL + P + L +Y Q
Sbjct: 163 EISWFD--VNDTGELNTRLTEEFPASAFTLCTATLGGVDDLMDVLLFSNGSDVYKIQEGI 220
Query: 1245 XXXXXXXXLAFV------MIGL--AYKISLM-----------------------NVEQIQ 1159
A+ +IG +K++L+ + EQ
Sbjct: 221 GDKVGLLIQAYTTFITAFIIGFTTGWKLTLVILAVSPALAISAAFFSKVLASFTSKEQTA 280
Query: 1158 NDDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFM 979
AG +A E++ ++T+ + + Y + + K +KK AI+ ++ F
Sbjct: 281 YAKAGAVAEEVLSAIRTVFAFSGQTREIERYHKNLRDAKDVGVKK----AISSNIAMGFT 336
Query: 978 YFMMCFTYAV----GIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAA 811
+ M+ +YA+ G +I + + + +++GA +V ++ F A+ AA
Sbjct: 337 FLMIYLSYALAFWYGSTLILNFEYTIGNLLTVFFVVLIGAFSVGQTSPNIQNFASARGAA 396
Query: 810 GMLFNIIYRKPRTGDLME-GDRPE-IRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQT 637
+++II KP E G +P+ I+G+I F+N+ F+YP RP I+ + + GQT
Sbjct: 397 YKVYSIIDNKPNIDSFSEDGFKPDFIKGDIEFKNIHFNYPSRPEVKILNNMSLSVKSGQT 456
Query: 636 VALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAG 457
+ALVG SG GKST I +L+RFYD GA+ IDG DIR L++ +LR + +V QEP LFA
Sbjct: 457 IALVGSSGCGKSTTIQLLQRFYDPEEGAVFIDGHDIRSLNIRYLREMIGVVSQEPVLFAT 516
Query: 456 TIRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIA 277
TI EN+ G DV E+I +A + +NA F+ NLP +T VG++G QLSGGQKQRIAIA
Sbjct: 517 TITENIRYGRLDVTQEEIERATKESNAYDFIMNLPDKFETLVGDRGTQLSGGQKQRIAIA 576
Query: 276 RALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYID 97
RALVR+PKILLLDEATSALD+ESE VQ ALD+ R GRT I +AHRLS+I+N+D+I
Sbjct: 577 RALVRNPKILLLDEATSALDAESETIVQAALDKVRLGRTTIVVAHRLSTIRNADIIAGFS 636
Query: 96 KGKVQEAGNHTQLMHQKGRYYKLIKKQ 16
GK+ E G H+QLM KG Y+ L+ Q
Sbjct: 637 NGKIVEQGTHSQLMEIKGVYHGLVTMQ 663
>gi|39595964|emb|CAE67467.1| Hypothetical protein CBG12969
[Caenorhabditis briggsae]
Length = 1231
Score = 730 bits (1884), Expect = 0.0
Identities = 425/1230 (34%), Positives = 668/1230 (53%), Gaps = 13/1230 (1%)
Frame = -1
Query: 3750 ANQQLEAQPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPP 3571
+++ + S L RY K D LLL +G +I G + A++ +T+ L+
Sbjct: 21 SSESSSSNSFSYCSLLRYSNKVDRLLLGLGIFLSISQGCCSSLNAILFRDLTDVLISGQG 80
Query: 3570 T-------SKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSV 3412
+ +QF N+ ++ + G + +F+ C+ C R + ++R + ++
Sbjct: 81 SYTNQTFDHQQFNNETLNIIHTYFLYGTLLFSLSFVSMCCWHTFCERQIFKIRVAYFSAL 140
Query: 3411 LRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLA 3232
LRQ+ WFD+N SG ++ND +ER+R+G+GDKLGV++ + +A+ +
Sbjct: 141 LRQDWEWFDQNDSGAAIVRMNDGLERVRDGLGDKLGVIIAYLTHFFCGLSLAFYLSVEMT 200
Query: 3231 SMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVG 3052
+ L + P + + + + ++ T KEL A + A E + G++TV +FNG+++ +
Sbjct: 201 IVTLIITPAFILPIIISRKMISKVTFKELEAYESAATAAGEVISGIKTVVSFNGEQKEIN 260
Query: 3051 RYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGM-LYGAYLLKVGIITTPGDVFI 2875
RY L K + +W+ +G L+ G IT PG
Sbjct: 261 RYSKFLSKAMYWGLWRASLSSFEGLLGHSSCVFQWQFHSGWWGTRLVLKGSIT-PGTTLA 319
Query: 2874 VVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVK 2695
V ++ YF+G PH+ + + +A ++Q IDR +D S G +L V G+VK
Sbjct: 320 VFWAVNGAIYFVGQAIPHLTSVSSCYSAAVPVFQIIDRTVILDGTSDKGLKLSKVKGKVK 379
Query: 2694 FENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTI 2515
FENV F+YP+R+ +L G++L PG ++ALVGHSG GKST+ L+ YE G ++I
Sbjct: 380 FENVWFKYPARQKVNVLKGISLHANPGENIALVGHSGSGKSTTAALMMHFYELNGGKISI 439
Query: 2514 DGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFI 2335
D T++ ELN+ LRN VGIV QEP+LF DT+ NN+ +G P M CK+ANAHDFI
Sbjct: 440 DDTNIDELNLSHLRNIVGIVSQEPLLFADTVENNMRLGAPDLDDNEMEYYCKLANAHDFI 499
Query: 2334 EKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSAL 2155
E++P GY T IG+GGV+LSGGQ+QR+AIARTL R P +L+LDEATSALD++SES+VQ AL
Sbjct: 500 EQLPNGYKTAIGNGGVELSGGQRQRIAIARTLARKPSILILDEATSALDSESESLVQIAL 559
Query: 2154 NNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKA 1975
NA++GRTTI IAHRL TIR ++I F+ G IVE G+H+EL+ G Y +V++Q+ +
Sbjct: 560 ENAAEGRTTITIAHRLGTIRNCNRIYVFDDGKIVEVGSHQELMEKDGHYAKMVQSQEIEV 619
Query: 1974 DPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXXX 1795
+ + F + + + S + K
Sbjct: 620 GNRQESTMEEYSFE--------SRRESCDSKSSRQKFSKKTARSCSLTSEK--------- 662
Query: 1794 XXXXXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVF 1615
E+ + + +L+I + K + + + + +++RG P ++++G +F
Sbjct: 663 -LLSDISPLPIGEENEQPSTFLEILRYTKPEWGLLAISILISVLRGFNYPIYSILYGRMF 721
Query: 1614 EGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNL 1435
M I ++G+ +A+ L V E L+ R R+ F N+
Sbjct: 722 R-ILSTGTDEEKSSNSGMNAIYLTALGIYALIVTMAAGCLIGYVGERLTKRLRILLFTNI 780
Query: 1434 LYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQ 1255
L QD YFD P HAPG+LITRL++DAPNI+A +D R+ V +
Sbjct: 781 LRQDGEYFDVPEHAPGRLITRLSTDAPNIRAAIDQRLADVIQGFSAVFCGIAIAFWF--- 837
Query: 1254 XXXXXXXXXXXLAFVMIGLAYKISLM-----NVEQIQNDDAGRIAIEIIENVKTIQLLTR 1090
V+I L I+ + + ++++ R+AIE +E +T+Q LTR
Sbjct: 838 -SPTMALMGLVNVGVLISLQGFITHVLKKRGEKDSERSEEPSRLAIEAVEQHRTVQYLTR 896
Query: 1089 CELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSD 910
+ F + L++G++++I+Y+L+ S+ F Y G+ ++ +
Sbjct: 897 EQSFVKKFADGMHPIHIRNLQRGILQSISYALSTSYTSFSFAIGYRFGLLLVDHDLANPF 956
Query: 909 DTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLMEGDRPEIRGN 730
F+ I ++ + +++ Y PEFV+A+ +AG+LF ++ +P+ D G + + +
Sbjct: 957 TVFQVIESLNSSSPSLLALGSYIPEFVRAQISAGLLFQMLRYEPKI-DSNTGKKTTLDSD 1015
Query: 729 ILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGAL 550
I +NV F Y + I+K G+T A+VG SG GKST I +LERFYD G +
Sbjct: 1016 ISLKNVYFGYQVSGRKMILKDFTLKIESGKTTAIVGASGCGKSTTIQLLERFYDPIAGRI 1075
Query: 549 RIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGLKDVPLEKINQALELANANR 370
++R L+L HLR+Q+ALV QEP LF +IR+N+ GL+ + ++ QA ++A+A+
Sbjct: 1076 DFGSTNLRDLNLKHLRSQVALVEQEPTLFNYSIRKNIAYGLESIKEGEVIQAAKIAHAHE 1135
Query: 369 FLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQE 190
F+ +LP G DT VGE G +LSGGQKQRIAIARA+VR+PKILLLDEA SALD ESER VQE
Sbjct: 1136 FITSLPEGYDTIVGEGGSKLSGGQKQRIAIARAIVRNPKILLLDEAMSALDVESERLVQE 1195
Query: 189 ALDRAREGRTCITIAHRLSSIQNSDLIVYI 100
AL++A+EGRTC+ IAHRL++I+ + LI+ +
Sbjct: 1196 ALEKAKEGRTCVVIAHRLTTIRGALLILIV 1225
Score = 237 bits (604), Expect = 2e-60
Identities = 146/391 (37%), Positives = 212/391 (53%), Gaps = 7/391 (1%)
Frame = -1
Query: 1155 DDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMY 976
+ A A E+I +KT+ + + Y + L + + + L S
Sbjct: 233 ESAATAAGEVISGIKTVVSFNGEQKEINRYSKFLSKAMYWGLWRASLSSFEGLLGHSSCV 292
Query: 975 FMMCFTYAV-GIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLF 799
F F G R++ +G + T A+ V + + +AA +F
Sbjct: 293 FQWQFHSGWWGTRLVLKGSITPGTTLAVFWAVNGAIYFVGQAIPHLTSVSSCYSAAVPVF 352
Query: 798 NIIYRKPRTGDLMEGDRPE------IRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQT 637
II R +++G + ++G + FENV F YP R ++KG+ A G+
Sbjct: 353 QIIDRTV----ILDGTSDKGLKLSKVKGKVKFENVWFKYPARQKVNVLKGISLHANPGEN 408
Query: 636 VALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAG 457
+ALVG SGSGKST ++ FY++ GG + ID +I +L+L HLR + +V QEP LFA
Sbjct: 409 IALVGHSGSGKSTTAALMMHFYELNGGKISIDDTNIDELNLSHLRNIVGIVSQEPLLFAD 468
Query: 456 TIRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIA 277
T+ N+ LG D+ ++ +LANA+ F+ LP G T +G G +LSGGQ+QRIAIA
Sbjct: 469 TVENNMRLGAPDLDDNEMEYYCKLANAHDFIEQLPNGYKTAIGNGGVELSGGQRQRIAIA 528
Query: 276 RALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYID 97
R L R P IL+LDEATSALDSESE VQ AL+ A EGRT ITIAHRL +I+N + I D
Sbjct: 529 RTLARKPSILILDEATSALDSESESLVQIALENAAEGRTTITIAHRLGTIRNCNRIYVFD 588
Query: 96 KGKVQEAGNHTQLMHQKGRYYKLIKKQDLAV 4
GK+ E G+H +LM + G Y K+++ Q++ V
Sbjct: 589 DGKIVEVGSHQELMEKDGHYAKMVQSQEIEV 619
>gi|6472653|dbj|BAA87071.1| multi-drug resistance related mRNA [Felis
catus]
Length = 1163
Score = 723 bits (1866), Expect = 0.0
Identities = 435/1142 (38%), Positives = 636/1142 (55%), Gaps = 13/1142 (1%)
Frame = -1
Query: 3558 FRNKANENV----YIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGW 3391
F N+ E + Y + GIG + + +IQ + R + ++R +F ++++RQ GW
Sbjct: 44 FINRLEEEMTTYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQILKIRKQFFHAIMRQEVGW 103
Query: 3390 FDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVA 3211
FD + G + T+L D + +I EGIGDK+G+ + A +V + W+L ++L ++
Sbjct: 104 FDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFIGFIVGFTRGWKLTLVILAIS 163
Query: 3210 PTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELE 3031
P + ++ A+ ++S T KEL+ KAG++AEE L +RTV AF GQ++ + RY LE
Sbjct: 164 PVLGLSAAIWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLE 223
Query: 3030 KGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLG 2851
+ ++ + K YG L+ + + G V V S+L+G
Sbjct: 224 EAKRIGIKKAITANISIGIAFLLIYASYALAFWYGTSLV-LSHEYSIGQVLTVFFSVLIG 282
Query: 2850 AYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRY 2671
A+ +G SP + NAR +A I++ ID P ID YSK G + N+ G ++F+NVHF Y
Sbjct: 283 AFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKNGHKPDNIKGNLEFKNVHFSY 342
Query: 2670 PSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVREL 2491
PSRK+ KIL GLNL V+ G +VALVG+SGCGKST+V L+ RLY+P G V+IDG D+R +
Sbjct: 343 PSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTDGMVSIDGQDIRTI 402
Query: 2490 NIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYD 2311
N+ +LR +G+V QEP+LF TI N+ G T E + + K ANA+DFI K+P +D
Sbjct: 403 NVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMEEIEKAVKEANAYDFIMKLPNKFD 462
Query: 2310 TLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRT 2131
TL+G+ G QLSGGQKQR+AIAR L+R+PK+LLLDEATSALD++SE++VQ AL+ A KGRT
Sbjct: 463 TLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDSESEAVVQVALDKARKGRT 522
Query: 2130 TIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKADPXXXXXX 1951
TI++AHRLSTIR AD I F+ GVIVE GNH+EL++ G YF LV Q
Sbjct: 523 TIVVAHRLSTIRNADVIAGFDDGVIVEKGNHDELMKEEGIYFKLVTMQ-----------T 571
Query: 1950 XXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXXXXXXXXXXX 1771
EI+L++ ++ G+SL S K
Sbjct: 572 RGNEIELENAVYESISEIDALEMSPKDS---GSSLIRRRSTRK----SIHASQGQDRKLG 624
Query: 1770 XXXXEDGQI-TAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVP 1594
D ++ + I K + Y +G A+I G PA ++I + FT V
Sbjct: 625 TKENLDERVPPVSFWRILKLNITEWPYFVVGIFCAIINGGLQPAFSVILSRIIGVFTRVE 684
Query: 1593 YGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASY 1414
+ + F +G+ + F E L+ R R FR++L QD S+
Sbjct: 685 DPETKRQNSNIFSLLFLVLGIISSITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSW 744
Query: 1413 FDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXX 1234
FD+P + G L TRLA+DA +K + +R+ + IY WQ
Sbjct: 745 FDDPKNTTGALTTRLANDAAQVKGAIGSRLAIITQNIANLGTGIIISLIYGWQ---LTLL 801
Query: 1233 XXXXLAFVMIGLAYKISLMNVEQIQN----DDAGRIAIEIIENVKTIQLLTRCELFFDHY 1066
+ + I ++ +++ + +++ + AG++A E IEN +T+ LTR + F Y
Sbjct: 802 LLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKVATEAIENFRTVVSLTREQKFEYMY 861
Query: 1065 QTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIA 886
S + R+ L+K I I++S+TQ+ MYF + G ++ D A
Sbjct: 862 AQSLQVPYRNSLRKAHIFGISFSITQAMMYFSYAGCFRFGAYLVAHEFMDFQDVLLVFSA 921
Query: 885 MMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDL-MEGDRPE-IRGNILFENV 712
++ GA+AV + + P++ KAK +A + II + P EG P + GN+ F V
Sbjct: 922 IVFGAMAVGQVSSFAPDYAKAKVSAAHVIMIIEKIPLIDSYSTEGLMPNTLEGNVTFNEV 981
Query: 711 KFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQD 532
F+YP RP P+++GL +GQT+ALVG SG GKST + +LERFYD G + IDG++
Sbjct: 982 MFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVLIDGKE 1041
Query: 531 IRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG--LKDVPLEKINQALELANANRFLAN 358
I+ L++ LR M +V QEP LF +I EN+ G + V E+I +A + AN + F+
Sbjct: 1042 IKHLNVQWLRAHMGIVSQEPILFDCSIGENIAYGDNSRVVSQEEIVRAAKEANIHPFIET 1101
Query: 357 LPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDR 178
LP +T VG+KG QLSGGQKQRIAIARALVR P+ILLLDEATSALD+ESE+ VQEALD+
Sbjct: 1102 LPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPRILLLDEATSALDTESEKVVQEALDK 1161
Query: 177 AR 172
AR
Sbjct: 1162 AR 1163
Score = 329 bits (843), Expect = 4e-88
Identities = 188/514 (36%), Positives = 289/514 (55%), Gaps = 7/514 (1%)
Frame = -1
Query: 3666 IGTICAIISGVSQPILALVSGRVTNALL-VYPPTSKQFRNKANENVY--IFLGIGIFISI 3496
+G CAII+G QP +++ R+ V P +K + N N++ +FL +GI SI
Sbjct: 654 VGIFCAIINGGLQPAFSVILSRIIGVFTRVEDPETK----RQNSNIFSLLFLVLGIISSI 709
Query: 3495 TNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFD--KNHSGTITTKLNDSMERIREG 3322
T F+Q F + ++R+ S+LRQ+ WFD KN +G +TT+L + +++
Sbjct: 710 TFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGA 769
Query: 3321 IGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELI 3142
IG +L ++ + A L I+++ IY W+L ++L + P I + + ++ +K+
Sbjct: 770 IGSRLAIITQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKK 829
Query: 3141 GVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXX 2962
+ AG +A E++ RTV + +++ Y L+ + ++ K
Sbjct: 830 ELEGAGKVATEAIENFRTVVSLTREQKFEYMYAQSLQVPYRNSLRKAHIFGISFSITQAM 889
Query: 2961 XXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAAS 2782
+GAYL+ + DV +V +++ GA +G +S A+VSAA
Sbjct: 890 MYFSYAGCFRFGAYLVAHEFMDFQ-DVLLVFSAIVFGAMAVGQVSSFAPDYAKAKVSAAH 948
Query: 2781 IYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVA 2602
+ I+++P ID YS G + G V F V F YP+R D +L GL+L V+ G ++A
Sbjct: 949 VIMIIEKIPLIDSYSTEGLMPNTLEGNVTFNEVMFNYPTRPDIPVLQGLSLEVKKGQTLA 1008
Query: 2601 LVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTI 2422
LVG SGCGKST V LL R Y+P AG V IDG +++ LN++WLR +GIV QEPILF+ +I
Sbjct: 1009 LVGSSGCGKSTVVQLLERFYDPMAGTVLIDGKEIKHLNVQWLRAHMGIVSQEPILFDCSI 1068
Query: 2421 HNNLLIGNPGS--TRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIA 2248
N+ G+ ++E ++ K AN H FIE +P Y+T +GD G QLSGGQKQR+AIA
Sbjct: 1069 GENIAYGDNSRVVSQEEIVRAAKEANIHPFIETLPDKYNTRVGDKGTQLSGGQKQRIAIA 1128
Query: 2247 RTLIRDPKVLLLDEATSALDAQSESIVQSALNNA 2146
R L+R P++LLLDEATSALD +SE +VQ AL+ A
Sbjct: 1129 RALVRQPRILLLDEATSALDTESEKVVQEALDKA 1162
Score = 315 bits (808), Expect = 4e-84
Identities = 193/531 (36%), Positives = 288/531 (53%), Gaps = 8/531 (1%)
Frame = -1
Query: 1584 RMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDN 1405
R+ M ++ +G GV + + + + ++ R Q F ++ Q+ +FD
Sbjct: 47 RLEEEMTTYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQILKIRKQFFHAIMRQEVGWFD- 105
Query: 1404 PAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXX 1225
H G+L TRL D I + ++ W+
Sbjct: 106 -VHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFIGFIVGFTRGWKLTLVILAISP 164
Query: 1224 XLAFVMIGLAYKI------SLMNVEQIQNDDAGRIAIEIIENVKTIQLLTRCELFFDHYQ 1063
++GL+ I S + E + AG +A E++ ++T+ + + Y
Sbjct: 165 -----VLGLSAAIWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYN 219
Query: 1062 TSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAM 883
+ ++ KR +KK + I+ + +Y + G ++ + S ++
Sbjct: 220 KNLEEAKRIGIKKAITANISIGIAFLLIYASYALAFWYGTSLVLSHEYSIGQVLTVFFSV 279
Query: 882 MLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLME-GDRPE-IRGNILFENVK 709
++GA +V ++ F A+ AA +F II KP + G +P+ I+GN+ F+NV
Sbjct: 280 LIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKNGHKPDNIKGNLEFKNVH 339
Query: 708 FSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDI 529
FSYP R I+KGL GQTVALVG SG GKST + +++R YD T G + IDGQDI
Sbjct: 340 FSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTDGMVSIDGQDI 399
Query: 528 RKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGLKDVPLEKINQALELANANRFLANLPA 349
R +++ +LR + +V QEP LFA TI EN+ G ++V +E+I +A++ ANA F+ LP
Sbjct: 400 RTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMEEIEKAVKEANAYDFIMKLPN 459
Query: 348 GIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRARE 169
DT VGE+G QLSGGQKQRIAIARALVR+PKILLLDEATSALDSESE VQ ALD+AR+
Sbjct: 460 KFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDSESEAVVQVALDKARK 519
Query: 168 GRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQ 16
GRT I +AHRLS+I+N+D+I D G + E GNH +LM ++G Y+KL+ Q
Sbjct: 520 GRTTIVVAHRLSTIRNADVIAGFDDGVIVEKGNHDELMKEEGIYFKLVTMQ 570
>gi|22026798|ref|NP_523740.2| CG8523-PA [Drosophila melanogaster]
gi|21645421|gb|AAF58271.2| CG8523-PA [Drosophila melanogaster]
Length = 1287
Score = 722 bits (1864), Expect = 0.0
Identities = 430/1279 (33%), Positives = 681/1279 (52%), Gaps = 35/1279 (2%)
Frame = -1
Query: 3735 EAQPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALL--------- 3583
+ + VS LFRY K D L IG + A+ +G++ P +L+ G + N ++
Sbjct: 41 DVKQVSYFQLFRYATKKDRALYVIGLLSAVATGLTTPANSLIFGNLANDMIDLGGLLESG 100
Query: 3582 --------VYPPTSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHR 3427
+ + R + +N YI GI + + +++ CF + + +R +
Sbjct: 101 KSYRADDAISTLLLDKVRQFSLQNTYI----GIIMLVCSYLSITCFNYAAHSQILTIRSK 156
Query: 3426 FVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIY 3247
F S+L Q+ W+D N SG + +++N+ + ++ +G+ +K+ + + + ++V+A++
Sbjct: 157 FFRSILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVK 216
Query: 3246 EWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQ 3067
W+L+ + L P I M L+A + KE+ A +AE +L G+RTV+AF G+
Sbjct: 217 GWQLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGE 276
Query: 3066 EEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTP- 2890
+ V Y+ + + + + YG L+ G
Sbjct: 277 AKEVAAYKERVVAAKILNIKRNMFSGIGFGLLWFFIYASYALAFWYGVGLVIKGYHEPAY 336
Query: 2889 -----GDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGK 2725
G + V S+++G+ +G+ +P++ A+ + A ++ I+++P+I+P GK
Sbjct: 337 ENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEINPIDGEGK 396
Query: 2724 RLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRL 2545
+L + ++F+ V F+YP+R + ILN LNL + G +VALVG SGCGKST + L+ R
Sbjct: 397 KLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRF 456
Query: 2544 YEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEV 2365
Y+P+AGN+ +GT++++L+I WLR+ +G+V QEPILF +I+ N+ G +TRE +
Sbjct: 457 YDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGREDATREEIEAA 516
Query: 2364 CKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDA 2185
ANA FI+K+PKGYDTL+G+ G QLSGGQKQR+AIAR LIRDP++LLLDEATSALD
Sbjct: 517 AAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDT 576
Query: 2184 QSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYF 2005
SE+ VQ+AL S GRTTI++AHRLST+R AD+IV KG +VE+G H+EL+ L YF
Sbjct: 577 ASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYF 636
Query: 2004 DLVKAQQFKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGS 1825
+LV Q + D + D + + D +
Sbjct: 637 NLVTTQLGEDDGSVLSPTGDIYKNFDIKDEDEEEIKVLSEDEDEDVM-----VTDEKNKK 691
Query: 1824 KRSXXXXXXXXXXXXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELP 1645
K+ +D L++ K K +L + +G + ++I G +P
Sbjct: 692 KKK----------------KKVKDPNEVKPMLEVMKMNKPEWLQIAVGCISSVIMGCAMP 735
Query: 1644 ALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSM 1465
A++FG + + + + + F G+ V + F + E L+
Sbjct: 736 IFAVLFGSILQILSVKDNDQYVRENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTE 795
Query: 1464 RFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXX 1285
R R F +L Q+ ++FD+ A+ G L RL+ DA ++ R+ +
Sbjct: 796 RLRGLMFEAMLRQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALG 855
Query: 1284 XXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQN----DDAGRIAIEIIEN 1117
Y W F++I + +LM E + + ++ ++A+E++ N
Sbjct: 856 IALSMYYEW---SLGLVALAFTPFILIAFYMQRTLMAKENMGSAKTMENCTKLAVEVVSN 912
Query: 1116 VKTIQLLTRCELFFDHY----QTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAV 949
++T+ L R E+F +Y + + KR+ +G++ Y L +S M+F
Sbjct: 913 IRTVASLGREEMFHQNYIGMLIPAVEISKRNTHFRGLV----YGLARSLMFFAYAACMYY 968
Query: 948 GIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTG 769
G + D FK A+++G ++ N+ + P K +AA +F + R+P
Sbjct: 969 GTWCVIHRGILFGDVFKVSQALIMGTASIANALAFAPNMQKGVSAAKTIFTFLRRQPSIV 1028
Query: 768 DL--MEGDRPEIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTN 595
D + D G + F+ VKFSYP R ++KGL+ +GQ +ALVGPSG GKST
Sbjct: 1029 DRPGVSRDPWHSEGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTC 1088
Query: 594 IGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG--LKD 421
I +++RFYDV GA ID D+R +S+ +LR Q+ +V QEP LF TIREN+ G ++
Sbjct: 1089 IQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARN 1148
Query: 420 VPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLL 241
V ++I A + +N + F+ANLP G DT +GEKG QLSGGQKQRIAIARAL+R+PKI+LL
Sbjct: 1149 VTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLL 1208
Query: 240 DEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQ 61
DEATSALD+ESE+ VQ+ALD A EGRT I+IAHRLS++ +SD+I + G V EAG+H Q
Sbjct: 1209 DEATSALDAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQ 1268
Query: 60 LMHQKGRYYKLIKKQDLAV 4
L+ +G YY L K Q A+
Sbjct: 1269 LLANRGLYYTLYKLQSGAM 1287
>gi|2673951|gb|AAB88657.1| multidrug resistance protein 1 [Aspergillus
fumigatus]
gi|2673953|gb|AAB88658.1| multidrug resistance protein 1 [Aspergillus
fumigatus]
Length = 1349
Score = 721 bits (1860), Expect = 0.0
Identities = 442/1277 (34%), Positives = 676/1277 (52%), Gaps = 28/1277 (2%)
Frame = -1
Query: 3756 DIANQQLEAQPVSIP--GLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNA-- 3589
++ +QL+A V + L+RY + D L++ + ICAI +G + P+ ++ G + +A
Sbjct: 81 EVLKRQLDAPSVKVSFFTLYRYASRKDILIILVSAICAIAAGAALPLFTILFGSLASAFQ 140
Query: 3588 -LLVYPPTSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSV 3412
+ + +F +K +NV F+ +GI +T ++ + F + + ++R ++ ++
Sbjct: 141 GISLGTMPYHEFYHKLTKNVLYFVYLGIAEFVTVYVSTVGFIYTGEHLTQKIRENYLEAI 200
Query: 3411 LRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLA 3232
LRQN +FDK +G +TT++ I++ I +K+G+ L FA + A +VAY+ W+LA
Sbjct: 201 LRQNMAYFDKLGAGEVTTRITADTNLIQDAISEKVGLTLTAFATFVTAFIVAYVKYWKLA 260
Query: 3231 SMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVG 3052
+ + M +R + + K + G G++AEE + +R AF Q+++
Sbjct: 261 LICTSTIVALVMVMGGGSRFIVKYSKKSIESYGAGGTVAEEVISSIRNATAFGTQDKLAK 320
Query: 3051 RYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIV 2872
+YE L + K+ V + G G G+ + VG G V V
Sbjct: 321 QYETHLAEAEKWGVKQQVILGMMIGGMFGIMFSNYGLGFWMGSRFV-VGKEVNVGQVLTV 379
Query: 2871 VMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKF 2692
+MS+L+G++ LG ++P+ N +AA IY TIDR +DPYS GK L + G ++F
Sbjct: 380 LMSILIGSFSLGNVAPNGQAFTNGVAAAAKIYSTIDRRSPLDPYSDEGKVLDHFEGNIEF 439
Query: 2691 ENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTID 2512
NV YPSR + ++ ++L + G + ALVG SG GKST VGL+ R Y P G V +D
Sbjct: 440 RNVKHIYPSRPEVTVMEDVSLSMPAGKTTALVGPSGSGKSTVVGLVERFYLPVGGQVLLD 499
Query: 2511 GTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNL---LIG------NPGSTRETMIEVCK 2359
G D++ LN+ WLR + +V QEP+LF+ TI N+ LIG + RE + +
Sbjct: 500 GHDIQTLNLRWLRQQISLVSQEPVLFSTTIFRNIEHGLIGTKFEHESKDKIRELVENAAR 559
Query: 2358 MANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQS 2179
MANAHDFI +P+GYDT +G G LSGGQKQR+AIAR ++ DPK+LLLDEATSALD +S
Sbjct: 560 MANAHDFIMALPEGYDTNVGQRGFLLSGGQKQRIAIARAIVSDPKILLLDEATSALDTKS 619
Query: 2178 ESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDL 1999
E +VQ+AL+ A++GRTTI+IAHRLSTI+ A IV G I E G H+ELV G Y+ L
Sbjct: 620 EGVVQAALDKAAEGRTTIVIAHRLSTIKTAHNIVAMVGGKIAEQGTHDELVDRKGTYYKL 679
Query: 1998 VKAQQFKADPXXXXXXXXXEIDLDD--TXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGS 1825
V+AQ+ + ++D DD +A L +G+
Sbjct: 680 VEAQRINEEKEAEALEADADMDADDFGQEGVTRIKTAVSSSNSLDAVDEKARLEMKRTGT 739
Query: 1824 KRSXXXXXXXXXXXXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELP 1645
++S ++ F + YM +G F+ + G P
Sbjct: 740 QKSVSSAVLSKKVPEQFEKYSL---WTLVKFIGAFNRPELG--YMLIGLTFSFLAGGGQP 794
Query: 1644 ALALIFGWVFEGFTFVPYGGRMMHRMAMAV----IAFASVGVGVWFSQLASSVLFAVVSE 1477
A ++ + + + M H++ + F VG+ + S + FA+ SE
Sbjct: 795 TQAFLYA---KAISTLSLPESMFHKLRHDANFWSLMFFVVGIAQFISLSINGTAFAICSE 851
Query: 1476 NLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXX 1297
L R R Q+FR++L QD S+FD ++ G L + L+++ N+ V + +
Sbjct: 852 RLIRRARSQAFRSILRQDISFFDREENSTGALTSFLSTETKNLSGVSGVTLGTIIMTSTT 911
Query: 1296 XXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQN---DDAGRIAIEI 1126
W+ + G L +Q + + A E
Sbjct: 912 LGAAMIIALAIGWK--LALVCISVVPILLACGFLRFYMLAQFQQRSKSAYEGSASYACEA 969
Query: 1125 IENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVG 946
++T+ LTR + + Y ++Q R L + ++ Y+ +Q+ ++F + + G
Sbjct: 970 TSAIRTVASLTREQDVWGVYHDQLQKQGRKSLISVLRSSLLYASSQALVFFCVALGFWYG 1029
Query: 945 IRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGD 766
++ + S F ++ GA + + P+ KAK AA + KP T D
Sbjct: 1030 GTLLGHHEYSIFRFFVCFSEILFGAQSAGTVFSFAPDMGKAKNAAAQFKKLFDSKP-TID 1088
Query: 765 LM--EGDRPE-IRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTN 595
+ EG++ E + G I F +V F YP RP QP+++GL + GQ +ALVGPSG GKST
Sbjct: 1089 IWSDEGEKLESMEGEIEFRDVHFRYPTRPEQPVLRGLNLSVKPGQYIALVGPSGCGKSTT 1148
Query: 594 IGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGL--KD 421
I +LERFYD G + +DG+DI KL++ R+ ++LV QEP L+ GTI+EN+ LG+ D
Sbjct: 1149 IALLERFYDALAGGVFVDGKDITKLNVNSYRSFLSLVSQEPTLYQGTIKENILLGVDKDD 1208
Query: 420 VPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLL 241
V E + + + AN F+ +LP G DT VG KGG LSGGQKQR+AIARAL+RDPK+LLL
Sbjct: 1209 VSEETLIKVCKDANIYDFVMSLPEGFDTVVGSKGGMLSGGQKQRVAIARALLRDPKVLLL 1268
Query: 240 DEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQ 61
DEATSALDSESE+ VQ ALD A GRT I +AHRLS+IQN+D+I D+GK+ E+G H +
Sbjct: 1269 DEATSALDSESEKVVQAALDAAARGRTTIAVAHRLSTIQNADIIYVFDQGKIVESGTHHE 1328
Query: 60 LMHQKGRYYKLIKKQDL 10
L+ KGRYY+L+ Q L
Sbjct: 1329 LIRNKGRYYELVNLQSL 1345
>gi|13641444|gb|AAK31736.1| p-glycoprotein [Mucor racemosus]
Length = 1292
Score = 720 bits (1858), Expect = 0.0
Identities = 453/1291 (35%), Positives = 684/1291 (52%), Gaps = 37/1291 (2%)
Frame = -1
Query: 3768 LCRGDIANQQL-------EAQPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALV 3610
L R D A+Q + + VSI LF++ D LL+ I C+ +G QPI L
Sbjct: 13 LLRDDTADQPATQDTKSKKKETVSIFRLFQFATTRDLLLICIAGFCSCTTGAIQPISILF 72
Query: 3609 SGRVTNAL--LVYPPTSKQFRNKANENVYIFLGIGIFIS--ITNFIQYMCFQHCCTRVMA 3442
G V L + +Y++LG G+ + I+N + + ++ R+
Sbjct: 73 FGNVLKKLGEAIVEGNDLMEATMPIIKLYVYLGTGVMTAAYISNCLWVLTGENQARRI-- 130
Query: 3441 QMRHRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIV 3262
R +V+S+LRQ WFDK+ G++TT+L+ ++ I++GI +K G L FA IA
Sbjct: 131 --RQLYVHSILRQEMSWFDKSEEGSLTTRLSADVQLIQDGISEKFGQFLMCFAQFIAGCS 188
Query: 3261 VAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQ 3082
VA+ WRL+ +M+ V P ++ +T T++ AGSI+E+ G+RTV
Sbjct: 189 VAFSKGWRLSIVMIAVTPAIACTGGVMGILVTKYTVETQDAYADAGSISEQVFAGIRTVY 248
Query: 3081 AFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGI 2902
+F+ Q RYE +L+K + + + G YG+ L+ I
Sbjct: 249 SFSLQNRFAKRYEEKLDKAMRAGIKRGIILGTGLGIFMFCLFAMYGLSFWYGSRLVHDHI 308
Query: 2901 ITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKR 2722
+ V +V +SM++G + L + ++ + +A +A I++TI RVP ID S G
Sbjct: 309 MDG-STVLVVFLSMMMGEFSLLQLPTNLAAVSSASAAAYKIFETIKRVPDIDTSSPDGVI 367
Query: 2721 LQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLY 2542
V+G ++F++V FRYP+R D IL L+L ++PG +VA VG SG GKSTSV LL R Y
Sbjct: 368 PSQVLGELEFKHVKFRYPTRPDTIILKDLSLKIKPGMTVAFVGPSGSGKSTSVQLLQRFY 427
Query: 2541 EPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIG--NPGSTRETMIE 2368
+P +G+V++DG +++ELN++WLR +G+V QEP+LFN +I NL++G N + E +
Sbjct: 428 DPMSGSVSLDGKNLKELNVKWLRQQIGVVSQEPVLFNTSIRQNLMMGSENRNISMEEITA 487
Query: 2367 VCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALD 2188
CK AN H FI+++PKGY TL+G+ G LSGGQKQR+AIAR ++++P +LLLDEATSALD
Sbjct: 488 ACKKANCHSFIKQLPKGYSTLVGEHGGMLSGGQKQRIAIARAILKNPAILLLDEATSALD 547
Query: 2187 AQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRY 2008
QSE +VQ AL+ A+ RTTI++AHRLST+R AD IV + G ++E G H++L+ GG Y
Sbjct: 548 TQSERLVQKALDEAAANRTTIVVAHRLSTVRNADLIVVMQHGDLIEQGTHDDLIAKGGVY 607
Query: 2007 FDLVKAQQFK-ADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGN--SLNDS 1837
+LVK QQ + + E + +D E R N S+
Sbjct: 608 SELVKKQQIQTSSNNTHNRKTKQEEEQEDEILLRNEAMEVNRKSCIELNRASNNASIISV 667
Query: 1836 FSGSKRSXXXXXXXXXXXXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRG 1657
+ K + ++ A +F + + + LG++ A I G
Sbjct: 668 PAARKSRFSVLDGFGREAASRKEAQEKHAKMKAPVWKVFMQMRPQWGWCMLGSIGACIAG 727
Query: 1656 LELPALALIFGWVF------EGFTFVPYGGRMMHRMAMAVIA-FASVGVGVWFSQLASSV 1498
P AL F V + + P G M+ ++ FA +G + +V
Sbjct: 728 TVFPLYALFFAKVITMLNENDDKDYGPMEGPNMYSFLFVILGMFAFLGFAL------QTV 781
Query: 1497 LFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQ 1318
F + + R F + + Q+ YFD + G L ++LA DA N+ ++
Sbjct: 782 SFEIAGAKYTKTLRSMLFVSFMKQEIGYFDRDENNVGSLTSKLAVDAKNVNEMITRAWPD 841
Query: 1317 VXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLA-----YKISLMNVEQIQND 1153
V ++ W+ +++G A + + N+
Sbjct: 842 VVQIAFTSAIGMTIAFMHSWKLTLIIMCMTP----LIVGAAGWNSKVQEGFEGSTKEANE 897
Query: 1152 DAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYF 973
+ +A E I+ ++T+ L + F + Y ++++ R +K +I ++L Q +
Sbjct: 898 QSAEVASEAIKEIRTVTALNKQSYFEERYYNATERPHRLAQRKAYTSSIGFALLQGTSLY 957
Query: 972 MMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNI 793
+ G ++I QG+ D ++++M+ A V S+ + F KAK AA F +
Sbjct: 958 TNAVAFYAGSKLITQGNLDLSDMVITMMSIMIMADGVGRSSIFVSTFAKAKIAAITTFEV 1017
Query: 792 IYRKPRTGDLMEGDRPE---IRGNILFENVKFSYPQRPLQPIMKG-LQWTALRGQTVALV 625
+ R+P +EG PE I G+I F ++ F YP RP PI G +GQT+ALV
Sbjct: 1018 LNRQPAIDSELEGIEPEGEDIDGDIDFSSIAFRYPARPDIPIFDGEFNLKGKQGQTIALV 1077
Query: 624 GPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRE 445
GPSGSGKST IGML+R+YD G +R+D +++ +L +LR+ MALV QEP LF TI E
Sbjct: 1078 GPSGSGKSTTIGMLQRWYDPLSGTVRVDNHNVKSYTLGNLRSHMALVSQEPTLFDMTIGE 1137
Query: 444 NVCLGL---KDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIAR 274
N+ G+ K+V E++ + AN + F+ +LP G D VG+KG QLSGGQKQRIAIAR
Sbjct: 1138 NIRFGVDDSKEVTQEEVEAVCKSANIHNFIVSLPKGYDQRVGDKGSQLSGGQKQRIAIAR 1197
Query: 273 ALVRDPKILLLDEATSALDSESERAVQEALDRARE--GRTCITIAHRLSSIQNSDLIVYI 100
AL+R PKILLLDEATSALDSESE+ VQ+ALD + GRT ITIAHRLS+I N+DLI I
Sbjct: 1198 ALIRKPKILLLDEATSALDSESEKLVQKALDNIIQEGGRTTITIAHRLSTITNADLICVI 1257
Query: 99 DKGKVQEAGNHTQLMHQKGRYYKLIKKQDLA 7
GKV E GNH QL+ G Y L+++Q L+
Sbjct: 1258 KDGKVIEQGNHWQLLKLDGVYKSLVQQQSLS 1288
Score = 296 bits (758), Expect = 3e-78
Identities = 192/575 (33%), Positives = 305/575 (52%), Gaps = 11/575 (1%)
Frame = -1
Query: 3666 IGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKANENVYIFLGI--GIFISIT 3493
+G+I A I+G P+ AL +V L K + N+Y FL + G+F +
Sbjct: 718 LGSIGACIAGTVFPLYALFFAKVITML--NENDDKDYGPMEGPNMYSFLFVILGMFAFLG 775
Query: 3492 NFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFDK--NHSGTITTKLNDSMERIREGI 3319
+Q + F+ + +R S ++Q G+FD+ N+ G++T+KL + + E I
Sbjct: 776 FALQTVSFEIAGAKYTKTLRSMLFVSFMKQEIGYFDRDENNVGSLTSKLAVDAKNVNEMI 835
Query: 3318 GDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIG 3139
+++ + +A+++ W+L +++ + P ++
Sbjct: 836 TRAWPDVVQIAFTSAIGMTIAFMHSWKLTLIIMCMTPLIVGAAGWNSKVQEGFEGSTKEA 895
Query: 3138 VGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXX 2959
++ +A E++ +RTV A N Q RY E+ + A K
Sbjct: 896 NEQSAEVASEAIKEIRTVTALNKQSYFEERYYNATERPHRLAQRKAYTSSIGFALLQGTS 955
Query: 2958 XXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASI 2779
G+ L+ G + D+ I +MS+++ A +G S + A+++A +
Sbjct: 956 LYTNAVAFYAGSKLITQGNLDL-SDMVITMMSIMIMADGVGRSSIFVSTFAKAKIAAITT 1014
Query: 2778 YQTIDRVPKIDPYSKAGK-RLQNVVGRVKFENVHFRYPSRKDAKILNG-LNLVVEPGTSV 2605
++ ++R P ID + + +++ G + F ++ FRYP+R D I +G NL + G ++
Sbjct: 1015 FEVLNRQPAIDSELEGIEPEGEDIDGDIDFSSIAFRYPARPDIPIFDGEFNLKGKQGQTI 1074
Query: 2604 ALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDT 2425
ALVG SG GKST++G+L R Y+P +G V +D +V+ + LR+ + +V QEP LF+ T
Sbjct: 1075 ALVGPSGSGKSTTIGMLQRWYDPLSGTVRVDNHNVKSYTLGNLRSHMALVSQEPTLFDMT 1134
Query: 2424 IHNNLLIGNPGS---TRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVA 2254
I N+ G S T+E + VCK AN H+FI +PKGYD +GD G QLSGGQKQR+A
Sbjct: 1135 IGENIRFGVDDSKEVTQEEVEAVCKSANIHNFIVSLPKGYDQRVGDKGSQLSGGQKQRIA 1194
Query: 2253 IARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASK--GRTTIMIAHRLSTIREADKI 2080
IAR LIR PK+LLLDEATSALD++SE +VQ AL+N + GRTTI IAHRLSTI AD I
Sbjct: 1195 IARALIRKPKILLLDEATSALDSESEKLVQKALDNIIQEGGRTTITIAHRLSTITNADLI 1254
Query: 2079 VFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKA 1975
+ G ++E GNH +L++L G Y LV+ Q +
Sbjct: 1255 CVIKDGKVIEQGNHWQLLKLDGVYKSLVQQQSLSS 1289
>gi|14030565|gb|AAK52958.1| bile salt export pump [Raja erinacea]
Length = 1348
Score = 718 bits (1854), Expect = 0.0
Identities = 433/1276 (33%), Positives = 673/1276 (51%), Gaps = 48/1276 (3%)
Frame = -1
Query: 3708 LFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYP--------------- 3574
LFR+ ++ L+ G +CA++ GV+QP + LV G +T+ + Y
Sbjct: 67 LFRFASCYEVTLMVFGGVCALLHGVAQPAVLLVFGLLTDTFIAYDIELQELKDTRKHCDN 126
Query: 3573 -----PTSKQFRNKANENV---------------YIFLGIGIFISITNFIQYMCFQHCCT 3454
++ N+ NE + Y ++GIG + + + Q +
Sbjct: 127 NTIHWVNGSEYLNQHNETMSCGILNIEKEMTMFAYYYVGIGCSVLLLGYFQICFWVTAAA 186
Query: 3453 RVMAQMRHRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLI 3274
R ++R + ++R GWFD N G + T+++D + +I + I D++G+ ++ F+ +
Sbjct: 187 RQTQKIRKAYFRQIMRMEMGWFDCNSVGELNTRMSDDINKINDAIADQVGIFIQRFSTFV 246
Query: 3273 AAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGV 3094
+ ++ ++ W+L +++ V+P + +L+A + T L KAG++A+E L +
Sbjct: 247 SGFLMGFVNGWKLTLVIIAVSPLIGLGAALMALSVARLTGLGLKAYAKAGAVADEVLSSI 306
Query: 3093 RTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLL 2914
RTV AF+G+++ V RY+ L +++ + K YG+ L+
Sbjct: 307 RTVAAFSGEKKEVDRYDRNLVFAQRWGIRKGMIMGFFTGYVWMIIFCCYALAFWYGSKLV 366
Query: 2913 KVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSK 2734
TPG + V + +L+ A LG SP + + R +A I++TIDR P+ID S+
Sbjct: 367 IEQNEYTPGGLLQVFLGVLVAAMNLGQASPCLEAFASGRGAAVKIFETIDREPEIDCMSE 426
Query: 2733 AGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLL 2554
G L V G ++F NV F YPSR D K L+ L++V++ G + A VG SG GKST+V L+
Sbjct: 427 GGYTLNKVKGDIEFHNVTFNYPSRPDVKTLDRLSMVIKAGETTAFVGPSGSGKSTAVELI 486
Query: 2553 TRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETM 2374
R Y+P+ G VT+DG D+R LNI+WLR+ +GIV+QEP+LF+ TI N+ G T+ +
Sbjct: 487 QRFYDPKQGMVTLDGHDIRSLNIQWLRSLIGIVEQEPVLFSTTIEENIRYVREGLTKNDI 546
Query: 2373 IEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSA 2194
++ K ANA+DFI +P+ ++TL+G+GG Q+SGGQKQR+AIAR L+R+PK+LLLD ATSA
Sbjct: 547 VQAAKEANAYDFIMDLPEKFNTLVGEGGGQMSGGQKQRIAIARALVRNPKILLLDMATSA 606
Query: 2193 LDAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGG 2014
LD +SE+IVQ AL+ GRTTI IAHRLST+R D I+ FE G VE G H EL+ G
Sbjct: 607 LDNESEAIVQGALDKVRFGRTTISIAHRLSTVRNVDVIIGFEHGRAVERGRHAELLERKG 666
Query: 2013 RYFDLVKAQQFKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNS----- 1849
YF LV Q D + R S
Sbjct: 667 IYFTLVTLQTQGEQALHEKARQVNGAIEDGASEKRQLIRRGSSRASVRSTRHQRSRSQVS 726
Query: 1848 --LND-SFSGSKRSXXXXXXXXXXXXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGT 1678
L+D S G S E+ A I K + YM G+
Sbjct: 727 EVLSDLSGPGDVASAVRTPSISLGDEDKDVEEEEESIEPAPVSRILKYNVSEWPYMLFGS 786
Query: 1677 VFALIRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSV 1498
+ A + G P AL+F + F+ + ++++ + F VG+ + +Q S
Sbjct: 787 LGAAVNGGVNPIYALLFSQILGTFS-LQNEEEKINQINAICLFFVVVGLVSFLTQFLQSY 845
Query: 1497 LFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQ 1318
FA E L+ R R F+ +L Q+ +FD+ ++PG L TRLA+DA ++ ++
Sbjct: 846 FFAKSGELLTRRLRKLGFQAMLRQEIGWFDDRKNSPGTLTTRLATDASQVQGATGTQIGM 905
Query: 1317 VXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKIS-LMNVEQIQNDDAGR 1141
+ + W+ LA A ++ N ++ + AG+
Sbjct: 906 IVNSITNIGVSLIIAFYFSWKLTLVILCFLPFLALTGALQARMLTGFANQDKEALEAAGQ 965
Query: 1140 IAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCF 961
I+ E + N++TI L + ++F ++ + ++ +KK + + + QS ++
Sbjct: 966 ISSEALSNIRTIAGLAKEKMFVQLFEAQLEAPYKAAIKKANVYGLCFGFAQSVIFLANAA 1025
Query: 960 TYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRK 781
+Y G ++ + F+ I A++ A+ ++ Y P++ KAK AA F +I R
Sbjct: 1026 SYRFGGYLVVAENLHFSIVFRVISAIVTSGTALGRASSYTPDYAKAKIAAARFFQLIDRA 1085
Query: 780 PRTG-DLMEGDR-PEIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSG 607
P+ D EG++ RG+I F F+YP RP ++ GL + GQT+A VG SG G
Sbjct: 1086 PKINIDSSEGEKWSNFRGDIKFVECTFTYPTRPDFQVLNGLSVCVMPGQTLAFVGSSGCG 1145
Query: 606 KSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG- 430
KST++ +LERFYD G + IDG+ ++ LR+++ +V QEP LF +I EN+ G
Sbjct: 1146 KSTSVQLLERFYDPNQGRVIIDGRSTTNVNTAFLRSKIGIVSQEPVLFDSSIEENIKYGD 1205
Query: 429 -LKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPK 253
+ V ++++ A + A + F+ +LP T VG +G QLS GQKQRIAIARA+VRDPK
Sbjct: 1206 NSRQVSMDEVIAAAKKAQLHSFVMSLPEKYGTRVGAQGSQLSRGQKQRIAIARAIVRDPK 1265
Query: 252 ILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAG 73
ILLLDEATSALD+ESE+ VQ+ALD AR+GRTCI IAHRLS+IQNSD+I + +G + E G
Sbjct: 1266 ILLLDEATSALDTESEKIVQDALDEARKGRTCIVIAHRLSTIQNSDIIAVMSRGIIIEQG 1325
Query: 72 NHTQLMHQKGRYYKLI 25
+H LM KG YYKL+
Sbjct: 1326 SHGNLMAAKGAYYKLV 1341
Score = 358 bits (918), Expect = 8e-97
Identities = 205/592 (34%), Positives = 324/592 (54%), Gaps = 5/592 (0%)
Frame = -1
Query: 3756 DIANQQLEAQPVSIPGLFRYG-KKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLV 3580
D+ ++ +P + + +Y ++ Y+L G++ A ++G PI AL+ ++ +
Sbjct: 755 DVEEEEESIEPAPVSRILKYNVSEWPYMLF--GSLGAAVNGGVNPIYALLFSQILGTFSL 812
Query: 3579 YPPTSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQN 3400
K N+ N F+ +G+ +T F+Q F + ++R ++LRQ
Sbjct: 813 QNEEEKI--NQINAICLFFVVVGLVSFLTQFLQSYFFAKSGELLTRRLRKLGFQAMLRQE 870
Query: 3399 AGWFD--KNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASM 3226
GWFD KN GT+TT+L +++ G ++G+++ + ++++A+ + W+L +
Sbjct: 871 IGWFDDRKNSPGTLTTRLATDASQVQGATGTQIGMIVNSITNIGVSLIIAFYFSWKLTLV 930
Query: 3225 MLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRY 3046
+L P + +L AR +T ++ + AG I+ E+L +RT+ ++ V +
Sbjct: 931 ILCFLPFLALTGALQARMLTGFANQDKEALEAAGQISSEALSNIRTIAGLAKEKMFVQLF 990
Query: 3045 EAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVM 2866
EA+LE K A+ K +G YL+ + VF V+
Sbjct: 991 EAQLEAPYKAAIKKANVYGLCFGFAQSVIFLANAASYRFGGYLVVAENLHF-SIVFRVIS 1049
Query: 2865 SMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFEN 2686
+++ LG S + A+++AA +Q IDR PKI+ S G++ N G +KF
Sbjct: 1050 AIVTSGTALGRASSYTPDYAKAKIAAARFFQLIDRAPKINIDSSEGEKWSNFRGDIKFVE 1109
Query: 2685 VHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGT 2506
F YP+R D ++LNGL++ V PG ++A VG SGCGKSTSV LL R Y+P G V IDG
Sbjct: 1110 CTFTYPTRPDFQVLNGLSVCVMPGQTLAFVGSSGCGKSTSVQLLERFYDPNQGRVIIDGR 1169
Query: 2505 DVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGS--TRETMIEVCKMANAHDFIE 2332
+N +LR+ +GIV QEP+LF+ +I N+ G+ + + +I K A H F+
Sbjct: 1170 STTNVNTAFLRSKIGIVSQEPVLFDSSIEENIKYGDNSRQVSMDEVIAAAKKAQLHSFVM 1229
Query: 2331 KMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALN 2152
+P+ Y T +G G QLS GQKQR+AIAR ++RDPK+LLLDEATSALD +SE IVQ AL+
Sbjct: 1230 SLPEKYGTRVGAQGSQLSRGQKQRIAIARAIVRDPKILLLDEATSALDTESEKIVQDALD 1289
Query: 2151 NASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLV 1996
A KGRT I+IAHRLSTI+ +D I +G+I+E G+H L+ G Y+ LV
Sbjct: 1290 EARKGRTCIVIAHRLSTIQNSDIIAVMSRGIIIEQGSHGNLMAAKGAYYKLV 1341
Score = 275 bits (703), Expect = 6e-72
Identities = 197/629 (31%), Positives = 308/629 (48%), Gaps = 51/629 (8%)
Frame = -1
Query: 1749 QITAGYLDIFKNAKG-NYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYG----- 1588
+I G+ +F+ A M G V AL+ G+ PA+ L+FG + + TF+ Y
Sbjct: 59 RIKIGFFQLFRFASCYEVTLMVFGGVCALLHGVAQPAVLLVFGLLTD--TFIAYDIELQE 116
Query: 1587 -------------------------------GRMMHRMAMAVIAFASVGVGVWFSQLA-- 1507
G + M + A+ VG+G L
Sbjct: 117 LKDTRKHCDNNTIHWVNGSEYLNQHNETMSCGILNIEKEMTMFAYYYVGIGCSVLLLGYF 176
Query: 1506 SSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDAR 1327
+ + + + R FR ++ + +FD ++ G+L TR++ D I + +
Sbjct: 177 QICFWVTAAARQTQKIRKAYFRQIMRMEMGWFD--CNSVGELNTRMSDDINKINDAIADQ 234
Query: 1326 MLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQN--- 1156
+ + W+ +IGL + ++V ++
Sbjct: 235 VGIFIQRFSTFVSGFLMGFVNGWKLTLVIIAVSP-----LIGLGAALMALSVARLTGLGL 289
Query: 1155 ---DDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQS 985
AG +A E++ +++T+ + + D Y + +R ++KGMI
Sbjct: 290 KAYAKAGAVADEVLSSIRTVAAFSGEKKEVDRYDRNLVFAQRWGIRKGMIMGFFTGYVWM 349
Query: 984 FMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGA-VAVMNSAQYFP---EFVKAKT 817
++ + G +++ + ++ T G++ + LG VA MN Q P F +
Sbjct: 350 IIFCCYALAFWYGSKLVIE---QNEYTPGGLLQVFLGVLVAAMNLGQASPCLEAFASGRG 406
Query: 816 AAGMLFNIIYRKPRTGDLMEGDRP--EIRGNILFENVKFSYPQRPLQPIMKGLQWTALRG 643
AA +F I R+P + EG +++G+I F NV F+YP RP + L G
Sbjct: 407 AAVKIFETIDREPEIDCMSEGGYTLNKVKGDIEFHNVTFNYPSRPDVKTLDRLSMVIKAG 466
Query: 642 QTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLF 463
+T A VGPSGSGKST + +++RFYD G + +DG DIR L++ LR+ + +V QEP LF
Sbjct: 467 ETTAFVGPSGSGKSTAVELIQRFYDPKQGMVTLDGHDIRSLNIQWLRSLIGIVEQEPVLF 526
Query: 462 AGTIRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIA 283
+ TI EN+ + + I QA + ANA F+ +LP +T VGE GGQ+SGGQKQRIA
Sbjct: 527 STTIEENIRYVREGLTKNDIVQAAKEANAYDFIMDLPEKFNTLVGEGGGQMSGGQKQRIA 586
Query: 282 IARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVY 103
IARALVR+PKILLLD ATSALD+ESE VQ ALD+ R GRT I+IAHRLS+++N D+I+
Sbjct: 587 IARALVRNPKILLLDMATSALDNESEAIVQGALDKVRFGRTTISIAHRLSTVRNVDVIIG 646
Query: 102 IDKGKVQEAGNHTQLMHQKGRYYKLIKKQ 16
+ G+ E G H +L+ +KG Y+ L+ Q
Sbjct: 647 FEHGRAVERGRHAELLERKGIYFTLVTLQ 675
>gi|48094917|ref|XP_394305.1| similar to ENSANGP00000021663 [Apis
mellifera]
Length = 5485
Score = 718 bits (1854), Expect = 0.0
Identities = 451/1322 (34%), Positives = 678/1322 (51%), Gaps = 88/1322 (6%)
Frame = -1
Query: 3705 FRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALL-------VYPPT------- 3568
FR+ + +L+F G I ++G+ PI + G T L+ PT
Sbjct: 3730 FRFATCGELMLIFGGLIMGTLTGLCIPISTIQYGEFTTLLVDRNMKNHTSTPTLIMKWFG 3789
Query: 3567 -------SKQFRNKANENVYIFLGIGIFISITNFIQYM-------CFQHCCTRVMAQMRH 3430
+ ++ + + G+ + + Q++ +R + ++R
Sbjct: 3790 GGKVLGSNSTYKERMEALYDDSVAFGVSSAALSTFQFVFAVFTVDLLNVAASRQIVRVRK 3849
Query: 3429 RFVYSVLRQNAGWFDKNHSGTITTKLNDS------------------------------- 3343
F+ SVLRQ+ W+D N S +++ D
Sbjct: 3850 MFLRSVLRQDMTWYDINTSTNFASRITDGNNLVNNLRDDAVFCHNGDRRGNHGGFDLEDE 3909
Query: 3342 ------------MERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCC 3199
++++++GIG+KLGV I++I+++++Y W+L ++L AP
Sbjct: 3910 CKRDRVDGGAKDLDKMKDGIGEKLGVFTYLMVSFISSIIISFVYGWKLTLVVLSCAPIIV 3969
Query: 3198 ICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRK 3019
I +++A+ +S T +EL G+AGS+AEE L +RTV AFNG+++ V RY +L K
Sbjct: 3970 IATAVVAKVQSSLTAQELTAYGQAGSVAEEVLGAIRTVIAFNGEQKEVNRYAEKLIPAEK 4029
Query: 3018 FAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLL-----KVGIITTPGDVFIVVMSMLL 2854
+ + YG L+ K TP + IV +L
Sbjct: 4030 TGIKRGMWSGVGGGVMWFIIYISYAIAFWYGVQLILEDRPKEVKEYTPAVLVIVFFGVLA 4089
Query: 2853 GAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFR 2674
GA +GL SPH+ AR SAA+I+Q +DRVP ID SK G++L V G ++F+NVHF+
Sbjct: 4090 GAQNMGLTSPHLEAFAVARGSAAAIFQVLDRVPTIDSLSKEGQKLPAVNGEIEFKNVHFQ 4149
Query: 2673 YPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRE 2494
YP+RKD K+L GLNL + G +VALVG SGCGKST + L+ RLY+P G V +DG DV +
Sbjct: 4150 YPARKDVKVLQGLNLTINRGETVALVGGSGCGKSTCLQLIQRLYDPHKGQVLLDGVDVSK 4209
Query: 2493 LNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGY 2314
LN++WLR+ +G+V QEP+LF+ TI N+ GN T E MI+ K ANAHDFI K+P+ Y
Sbjct: 4210 LNVQWLRSHIGVVGQEPVLFDTTIRENIRYGNDSITEEEMIKAAKEANAHDFISKLPEAY 4269
Query: 2313 DTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGR 2134
D+ +G+ G Q+SGGQKQR+AIAR L+R P +LLLDEATSALD SE+ VQ AL+ ASKGR
Sbjct: 4270 DSPVGERGSQMSGGQKQRIAIARALVRRPAILLLDEATSALDLHSEATVQRALDAASKGR 4329
Query: 2133 TTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKADPXXXXX 1954
TTI++ HRLSTI AD+IVF + G +VE G HEEL+ LG Y+ LV A
Sbjct: 4330 TTIVVTHRLSTITNADRIVFIKDGQVVEQGTHEELLALGKHYYGLVSA------------ 4377
Query: 1953 XXXXEIDLDDTXXXXXXXXXXXXXXXSEAF-RRGNSLNDSFSGSKRSXXXXXXXXXXXXX 1777
D + + A ++ L FS
Sbjct: 4378 --------DASATARAKATASAAKTVTAAIPKQKPPLKRQFSTLSMHSHRLSLAGASETS 4429
Query: 1776 XXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFV 1597
+ A + IF K + Y +G + A + G PA A++FG V+ +
Sbjct: 4430 ANQLEEHEKPYDAPMMRIFGLNKPEWPYNIIGCLAAAMVGASFPAFAVLFGEVY--YVLG 4487
Query: 1596 PYGGRMMHRMAMAV-IAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDA 1420
+ R + I F VGV +F + ++ R R +F +L Q+
Sbjct: 4488 LQDDEEVRRETVNFSILFLVVGVVTGLGTFLQMYMFGLAGVRMTTRIRKITFAAMLKQEM 4547
Query: 1419 SYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXX 1240
++D ++ G L RL+SDA ++ R+ + Y W+
Sbjct: 4548 GWYDEDTNSVGALCARLSSDAGAVQGATGTRVGAILQALSTLVLGIGLSMYYTWK---MT 4604
Query: 1239 XXXXXXLAFVMIGLAYKISLMNVEQIQN----DDAGRIAIEIIENVKTIQLLTRCELFFD 1072
+ V+ + ++ +M+ + +Q + A RIAIE I N++T+ L + E F
Sbjct: 4605 LVSVVSIPLVLGAVFFEARVMSGQGLQEKKKMEAATRIAIEAISNIRTVASLGKEEAFLQ 4664
Query: 1071 HYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGI 892
Y + + + + + +S Q+ +F + G ++ + D K
Sbjct: 4665 RYCSELDHVAEATRIRQRLRGLVFSCGQTTPFFGYALSLYYGGALVATEGLNYQDVIKVS 4724
Query: 891 IAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLMEGDRPEI----RGNIL 724
A++ G+ + + + P F AK +AG +F ++ R P + + ++ G I
Sbjct: 4725 EALIFGSWMLGQALAFAPNFNTAKISAGRIFKLLDRVPEIASPPDSEDKDLDWKADGLIQ 4784
Query: 723 FENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRI 544
F V+F YP RP I++GL GQ VALVG SG GKST I +L+R YD G + +
Sbjct: 4785 FSKVEFHYPTRPEMQILQGLNLIVKPGQMVALVGQSGCGKSTCIQLLQRLYDPISGTVTM 4844
Query: 543 DGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG--LKDVPLEKINQALELANANR 370
D +DI +SL +LR+Q+ +VGQEP LF TI EN+ G + VP+++I +A + +N +
Sbjct: 4845 DRRDISSVSLRNLRSQLGVVGQEPVLFDRTIAENIAYGDNFRLVPMDEIIEAAKKSNIHS 4904
Query: 369 FLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQE 190
F+++LP G DT +G KG QLSGGQKQRIAIARALVR+P++LLLDEATSALD++SE+ VQ
Sbjct: 4905 FVSSLPLGYDTRLGSKGTQLSGGQKQRIAIARALVRNPRVLLLDEATSALDTQSEKVVQA 4964
Query: 189 ALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQDL 10
ALD+A EGRTCITIAHRL++I+N+D+I ++KG V E G H L+ G Y L Q+
Sbjct: 4965 ALDKAMEGRTCITIAHRLATIRNADVICVLEKGTVAEMGTHDDLIAADGLYAHLHALQEA 5024
Query: 9 AV 4
A+
Sbjct: 5025 AM 5026
Score = 335 bits (858), Expect = 7e-90
Identities = 209/601 (34%), Positives = 322/601 (52%), Gaps = 12/601 (1%)
Frame = -1
Query: 3750 ANQQLEAQ-PVSIPGLFRYG-KKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVY 3577
ANQ E + P P + +G K ++ IG + A + G S P A++ G V L +
Sbjct: 4430 ANQLEEHEKPYDAPMMRIFGLNKPEWPYNIIGCLAAAMVGASFPAFAVLFGEVYYVLGLQ 4489
Query: 3576 PPTSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNA 3397
++ R + +FL +G+ + F+Q F R+ ++R ++L+Q
Sbjct: 4490 D--DEEVRRETVNFSILFLVVGVVTGLGTFLQMYMFGLAGVRMTTRIRKITFAAMLKQEM 4547
Query: 3396 GWFDK--NHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMM 3223
GW+D+ N G + +L+ ++ G ++G +L+ + L+ I ++ Y W++ +
Sbjct: 4548 GWYDEDTNSVGALCARLSSDAGAVQGATGTRVGAILQALSTLVLGIGLSMYYTWKMTLVS 4607
Query: 3222 LGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYE 3043
+ P + AR M+ ++E + A IA E++ +RTV + +E + RY
Sbjct: 4608 VVSIPLVLGAVFFEARVMSGQGLQEKKKMEAATRIAIEAISNIRTVASLGKEEAFLQRYC 4667
Query: 3042 AELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPG----DVFI 2875
+EL+ + + + YG L + T G DV
Sbjct: 4668 SELDHVAEATRIRQRLRGLVFSCGQTTPFFGYALSLYYGGAL-----VATEGLNYQDVIK 4722
Query: 2874 VVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKI-DPYSKAGKRLQ-NVVGR 2701
V +++ G++ LG A++SA I++ +DRVP+I P K L G
Sbjct: 4723 VSEALIFGSWMLGQALAFAPNFNTAKISAGRIFKLLDRVPEIASPPDSEDKDLDWKADGL 4782
Query: 2700 VKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNV 2521
++F V F YP+R + +IL GLNL+V+PG VALVG SGCGKST + LL RLY+P +G V
Sbjct: 4783 IQFSKVEFHYPTRPEMQILQGLNLIVKPGQMVALVGQSGCGKSTCIQLLQRLYDPISGTV 4842
Query: 2520 TIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGST--RETMIEVCKMANA 2347
T+D D+ +++ LR+ +G+V QEP+LF+ TI N+ G+ + +IE K +N
Sbjct: 4843 TMDRRDISSVSLRNLRSQLGVVGQEPVLFDRTIAENIAYGDNFRLVPMDEIIEAAKKSNI 4902
Query: 2346 HDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIV 2167
H F+ +P GYDT +G G QLSGGQKQR+AIAR L+R+P+VLLLDEATSALD QSE +V
Sbjct: 4903 HSFVSSLPLGYDTRLGSKGTQLSGGQKQRIAIARALVRNPRVLLLDEATSALDTQSEKVV 4962
Query: 2166 QSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQ 1987
Q+AL+ A +GRT I IAHRL+TIR AD I EKG + E G H++L+ G Y L Q
Sbjct: 4963 QAALDKAMEGRTCITIAHRLATIRNADVICVLEKGTVAEMGTHDDLIAADGLYAHLHALQ 5022
Query: 1986 Q 1984
+
Sbjct: 5023 E 5023
Score = 82.0 bits (201), Expect = 1e-13
Identities = 62/208 (29%), Positives = 101/208 (47%), Gaps = 1/208 (0%)
Frame = -1
Query: 645 GQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRL 466
G+ +L+G +G+GK+T I ML T G + ++G++ K + L+G
Sbjct: 2609 GEVTSLLGRNGAGKTTIIKMLTGMLAPTTGEICLNGEEGCKPDIGVCPQDNVLIGTL--- 2665
Query: 465 FAGTIRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRI 286
T RE++ K + K A N + L +L G + E +LSGG K+R+
Sbjct: 2666 ---TPREHLLFYAK-LKRSKEEYANVQRNVDEMLTSLELG--SQEHEPVYRLSGGTKRRL 2719
Query: 285 AIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQN-SDLI 109
+A A + PK+++LDE + +D + R + +D+ R GRT I H L SD +
Sbjct: 2720 CVALAFLGSPKLVILDEPGAGVDPAARRRIWRLIDQHRTGRTVILSTHHLDEADTLSDTV 2779
Query: 108 VYIDKGKVQEAGNHTQLMHQKGRYYKLI 25
V + KGK+ G+ L GR Y+L+
Sbjct: 2780 VVMHKGKILCTGSPLSLKMMHGRGYRLL 2807
Score = 72.4 bits (176), Expect = 8e-11
Identities = 60/254 (23%), Positives = 117/254 (45%), Gaps = 11/254 (4%)
Frame = -1
Query: 2700 VKFENVHFRYPSRKDAKI-LNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGN 2524
V+F+ V Y + + + ++ L + G +L+G +G GK+T + +LT + P G
Sbjct: 2580 VRFDGVRKVYNTDQGEIVAVDDFTLKLSEGEVTSLLGRNGAGKTTIIKMLTGMLAPTTGE 2639
Query: 2523 VTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAH 2344
+ ++G E + +G+ Q+ N+LIG + RE ++ K+ +
Sbjct: 2640 ICLNGE-------EGCKPDIGVCPQD----------NVLIGTL-TPREHLLFYAKLKRSK 2681
Query: 2343 DFIEKMPKGYDTLIG---------DGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSAL 2191
+ + + D ++ + +LSGG K+R+ +A + PK+++LDE + +
Sbjct: 2682 EEYANVQRNVDEMLTSLELGSQEHEPVYRLSGGTKRRLCVALAFLGSPKLVILDEPGAGV 2741
Query: 2190 DAQSESIVQSALNNASKGRTTIMIAHRLSTIRE-ADKIVFFEKGVIVEAGNHEELVRLGG 2014
D + + ++ GRT I+ H L +D +V KG I+ G+ L + G
Sbjct: 2742 DPAARRRIWRLIDQHRTGRTVILSTHHLDEADTLSDTVVVMHKGKILCTGSPLSLKMMHG 2801
Query: 2013 RYFDLVKAQQFKAD 1972
R + L+ + F AD
Sbjct: 2802 RGYRLLVS--FPAD 2813
Score = 61.2 bits (147), Expect = 2e-07
Identities = 61/241 (25%), Positives = 107/241 (44%), Gaps = 6/241 (2%)
Frame = -1
Query: 2748 DPYSKAGKRLQNVVGRVKFENVHFR--YPSRKDAKI-LNGLNLVVEPGTSVALVGHSGCG 2578
D SK R++ + + V R Y S + + L++ VE G L+G +G G
Sbjct: 3409 DDVSKERMRVEGGMSDDALQTVKLRKEYSSVYGTNVAVQNLSIGVEAGKCFGLLGTNGAG 3468
Query: 2577 KSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGN 2398
KST+ +LT P AG + + G ++ + VG Q +D I L +
Sbjct: 3469 KSTTFRMLTTEIIPTAGRIIVRGKEIGSGPL--CNGEVGYCPQ-----SDGIDGFL---S 3518
Query: 2397 PGSTRETMIEVCKMANAHDFIEKMPKGYDTL--IGDGGVQLSGGQKQRVAIARTLIRDPK 2224
P EVC ++N +E K D L LSGG K+++ A +++
Sbjct: 3519 PHQCLTIHGEVCGLSNVPKAVESALKRLDLLKYAHKRVSSLSGGNKRKLCTALSVMAPVP 3578
Query: 2223 VLLLDEATSALDAQSESIVQSALNNASKGRT-TIMIAHRLSTIREADKIVFFEKGVIVEA 2047
V+L+DE TS +D ++ +V + + ++ +T I+ +H ++ V G++ +A
Sbjct: 3579 VVLMDEPTSGMDPATKDLVTKTIKHLTRNQTCVILTSHSVADCENVCNRV----GILAKA 3634
Query: 2046 G 2044
G
Sbjct: 3635 G 3635
Score = 53.5 bits (127), Expect = 4e-05
Identities = 50/215 (23%), Positives = 98/215 (45%), Gaps = 11/215 (5%)
Frame = -1
Query: 645 GQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRL 466
G+ L+G +G+GKST ML T G + + G++I L + VG P+
Sbjct: 3456 GKCFGLLGTNGAGKSTTFRMLTTEIIPTAGRIIVRGKEIGSGPLCN-----GEVGYCPQS 3510
Query: 465 --FAGTIRENVCL-------GLKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQ 313
G + + CL GL +VP + + AL+ + ++ ++
Sbjct: 3511 DGIDGFLSPHQCLTIHGEVCGLSNVP-KAVESALKRLDLLKY-----------AHKRVSS 3558
Query: 312 LSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITI-AHRL 136
LSGG K+++ A +++ ++L+DE TS +D ++ V + + +TC+ + +H +
Sbjct: 3559 LSGGNKRKLCTALSVMAPVPVVLMDEPTSGMDPATKDLVTKTIKHLTRNQTCVILTSHSV 3618
Query: 135 SSIQN-SDLIVYIDKGKVQEAGNHTQLMHQKGRYY 34
+ +N + + + K ++ G L H+ G Y
Sbjct: 3619 ADCENVCNRVGILAKAGLRCIGTPQHLKHKFGEGY 3653
>gi|27656758|gb|AAO20902.1| Mdr2 [Takifugu rubripes]
Length = 1271
Score = 718 bits (1853), Expect = 0.0
Identities = 445/1319 (33%), Positives = 678/1319 (50%), Gaps = 107/1319 (8%)
Frame = -1
Query: 3651 AIISGVSQPILALVSGRVTNALLVYPPTSKQFRN---KANENV----------YIFLGIG 3511
AI++G+ P++ +V G +T++ + S+ +AN + Y LG
Sbjct: 2 AIVNGLVNPLMCIVFGEMTDSFIQEAKLSQNHNTSNPRANSTLEADMQRFSIYYSILGFA 61
Query: 3510 IFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFDKNHSGTITTKLND----- 3346
+ + ++Q + R ++R F + +++Q+ W+D +G + T+L +
Sbjct: 62 VLV--VAYLQMSLWTLTAARQAKRIRELFFHGIMQQDISWYDVTETGELNTRLTEWVTHI 119
Query: 3345 ------------------------SMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWR 3238
+ +I+EGIGDK G+L++ + I + V+ +++ W+
Sbjct: 120 IHTPVPVTAGVVVIICGVRFPGAHDVYKIQEGIGDKAGLLIQAASTFITSFVIGFVHGWK 179
Query: 3237 LASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEM 3058
L ++L ++P + +L ++ +TS T KE KAG++A E L +RTV AF+GQ +
Sbjct: 180 LTLVILAISPVLGLSAALYSKLLTSFTSKEQTAYAKAGAVAAEVLSSIRTVFAFSGQRKA 239
Query: 3057 VGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLL-----KVGIITT 2893
+ RY LE R + K YG L+ +G + T
Sbjct: 240 IKRYHKNLEDARDMGIKKGVAANTATGFSFLMIYLSYALAFWYGTTLVLNKEYTIGNLLT 299
Query: 2892 PGDVFI----------VVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDP 2743
V V +L GAY +G SP++ +AR +A +Y ID P ID
Sbjct: 300 NKSVAAETVTTCVQMKVFFVVLYGAYIIGQASPNVQSFASARGAAYKVYNIIDHKPNIDS 359
Query: 2742 YSKAGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSV 2563
+S+ G + + + G + F+N+HF YPSR + KILN ++ V G ++ALVG SGCGKST++
Sbjct: 360 FSEDGYKPEYIKGDIVFQNIHFSYPSRPEIKILNDMSFHVRNGQTIALVGSSGCGKSTTI 419
Query: 2562 GLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTR 2383
LL R Y+P+ G++ IDG D+R LNI +LR +G+V QEP+LF TI N+ G T+
Sbjct: 420 QLLQRFYDPQKGSIFIDGHDIRSLNIRYLREMIGVVSQEPVLFATTITENIRYGRLDVTQ 479
Query: 2382 ETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEA 2203
E + K +NA+DFI +P ++TL+GD G QLSGGQKQR+AIAR L+R+PK+LLLDEA
Sbjct: 480 EEIERATKESNAYDFIMNLPDKFETLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEA 539
Query: 2202 TSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVR 2023
TSALDA+SE+IVQ+AL+ GRTTI+IAHRLSTIR AD I F G IVE G H +L+
Sbjct: 540 TSALDAESETIVQAALDKVRLGRTTIVIAHRLSTIRNADIIAGFSNGEIVEQGTHSQLME 599
Query: 2022 LGGRYFDLVKAQQFKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGN-SL 1846
+ G Y LV Q F+ L+D E+F + +
Sbjct: 600 IKGVYHGLVTMQSFQ--------------KLEDLEDSDYEPWVAEKSQLIESFSQSSLQR 645
Query: 1845 NDSFSGSKRSXXXXXXXXXXXXXXXXXXXEDGQIT--AGYLDIFKNAKGNYLYMFLGTVF 1672
S GS + E+ + + + + + Y+ +GT+
Sbjct: 646 RRSTRGSLLAVSEGTKEEKEKFECDQDNIEEDENVPPVSFFKVMRYNVSEWPYILVGTIC 705
Query: 1671 ALIRGLELPALALIFG-----WVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLA 1507
A+I G P ++IF W F+GF F G
Sbjct: 706 AMINGAMQPVFSIIFTEIIMFWGFQGFCFSKSG--------------------------- 738
Query: 1506 SSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDAR 1327
E L++ R+++F +++ QD S++DNP + G L TRLA+DA +++ R
Sbjct: 739 ---------EILTLNLRLKAFISMMRQDLSWYDNPKNTVGALTTRLAADAAHVQGAAGVR 789
Query: 1326 MLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQN--- 1156
+ + +Y W+ LA + A ++ L+ ++
Sbjct: 790 LAVMTQNFANLGTSIIISFVYGWELTLLILAVVPILA---VAGAAEVKLLTGHAAEDKKE 846
Query: 1155 -DDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFM 979
+ AG+IA E IENV+T+ LTR F Y+ + ++ KK I + YS +Q+ +
Sbjct: 847 LEMAGKIATEAIENVRTVVSLTREPTFVALYEENLTVPYKNSQKKAKIYGLTYSFSQAMI 906
Query: 978 YFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLF 799
+F+ + G +I G + F ++ M+ GA+AV + Y P F KAK +A L
Sbjct: 907 FFVYAACFRFGAWLIEAGRMDVEGVFLVVMTMLYGAMAVGEANTYAPNFAKAKISASHLT 966
Query: 798 NIIYRKPRTGDLMEGDR--PEIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALV 625
+I R+P +L E + + GN+LFE+VKF+YP RP P+++GL +G+T+ALV
Sbjct: 967 MLINRQPAIDNLSEEEARLEKYDGNVLFEDVKFNYPSRPDVPVLQGLNLEVQKGETLALV 1026
Query: 624 GPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRE 445
G SG GKST I +LERFYD G + +DG D+++L++ LR+Q+ +V QEP LF ++ E
Sbjct: 1027 GSSGCGKSTTIQLLERFYDPREGRVLLDGVDVKQLNVHWLRSQIGIVSQEPVLFDCSLAE 1086
Query: 444 NVCLG--LKDVPLEKINQALELANANRFLANLP--------------------------- 352
N+ G + V +++I A + AN + F+ LP
Sbjct: 1087 NIAYGDNSRSVSMDEIVAAAKAANIHSFIEGLPQVAAVNQGKWLIPHLIDSHGAAHDHLH 1146
Query: 351 -------AGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQ 193
DT G+KG QLSGGQKQR+AIARA++R+PK+LLLDEATSALD+ESE+ VQ
Sbjct: 1147 HIQTVSEQRYDTQAGDKGTQLSGGQKQRVAIARAIIRNPKLLLLDEATSALDTESEKVVQ 1206
Query: 192 EALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQ 16
EALD+AR+GRTCI +AHRLS+IQN+D I G V E G H QL+ +KG Y+ L+ KQ
Sbjct: 1207 EALDQARKGRTCIVVAHRLSTIQNADCIAVFQGGVVVEKGTHQQLIAKKGVYHMLVTKQ 1265
Score = 364 bits (935), Expect = 8e-99
Identities = 225/632 (35%), Positives = 328/632 (51%), Gaps = 39/632 (6%)
Frame = -1
Query: 3765 CRGDIANQQLEAQPVSIPGLFRYG-KKFDYLLLFIGTICAIISGVSQPILALVSGRVTNA 3589
C D + PVS + RY ++ Y+L +GTICA+I+G QP+ ++
Sbjct: 669 CDQDNIEEDENVPPVSFFKVMRYNVSEWPYIL--VGTICAMINGAMQPVFSI-------- 718
Query: 3588 LLVYPPTSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVL 3409
IF I +F F CF + +R + S++
Sbjct: 719 --------------------IFTEIIMFWGFQGF----CFSKSGEILTLNLRLKAFISMM 754
Query: 3408 RQNAGWFD--KNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRL 3235
RQ+ W+D KN G +TT+L ++ G +L V+ + FA L +I+++++Y W L
Sbjct: 755 RQDLSWYDNPKNTVGALTTRLAADAAHVQGAAGVRLAVMTQNFANLGTSIIISFVYGWEL 814
Query: 3234 ASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMV 3055
++L V P + + + +T ++ + AG IA E++ VRTV + + V
Sbjct: 815 TLLILAVVPILAVAGAAEVKLLTGHAAEDKKELEMAGKIATEAIENVRTVVSLTREPTFV 874
Query: 3054 GRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFI 2875
YE L K + K +GA+L++ G + G VF+
Sbjct: 875 ALYEENLTVPYKNSQKKAKIYGLTYSFSQAMIFFVYAACFRFGAWLIEAGRMDVEG-VFL 933
Query: 2874 VVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVK 2695
VVM+ML GA +G + + A++SA+ + I+R P ID S+ RL+ G V
Sbjct: 934 VVMTMLYGAMAVGEANTYAPNFAKAKISASHLTMLINRQPAIDNLSEEEARLEKYDGNVL 993
Query: 2694 FENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTI 2515
FE+V F YPSR D +L GLNL V+ G ++ALVG SGCGKST++ LL R Y+P G V +
Sbjct: 994 FEDVKFNYPSRPDVPVLQGLNLEVQKGETLALVGSSGCGKSTTIQLLERFYDPREGRVLL 1053
Query: 2514 DGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGS--TRETMIEVCKMANAHD 2341
DG DV++LN+ WLR+ +GIV QEP+LF+ ++ N+ G+ + + ++ K AN H
Sbjct: 1054 DGVDVKQLNVHWLRSQIGIVSQEPVLFDCSLAENIAYGDNSRSVSMDEIVAAAKAANIHS 1113
Query: 2340 FIEKMP----------------------------------KGYDTLIGDGGVQLSGGQKQ 2263
FIE +P + YDT GD G QLSGGQKQ
Sbjct: 1114 FIEGLPQVAAVNQGKWLIPHLIDSHGAAHDHLHHIQTVSEQRYDTQAGDKGTQLSGGQKQ 1173
Query: 2262 RVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIREADK 2083
RVAIAR +IR+PK+LLLDEATSALD +SE +VQ AL+ A KGRT I++AHRLSTI+ AD
Sbjct: 1174 RVAIARAIIRNPKLLLLDEATSALDTESEKVVQEALDQARKGRTCIVVAHRLSTIQNADC 1233
Query: 2082 IVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQ 1987
I F+ GV+VE G H++L+ G Y LV Q
Sbjct: 1234 IAVFQGGVVVEKGTHQQLIAKKGVYHMLVTKQ 1265
>gi|15147363|gb|AAG01549.3| multidrug resistance protein MDR
[Trichophyton rubrum]
Length = 1331
Score = 717 bits (1852), Expect = 0.0
Identities = 443/1318 (33%), Positives = 696/1318 (52%), Gaps = 26/1318 (1%)
Frame = -1
Query: 3885 DPKSDPKIASDLPANYVDDDDDAPKMYTPSLLE-KILNYALCRGDIANQQL--EAQPVSI 3715
+P S SD + DA K TP L+ ++ + +I QQL +
Sbjct: 22 NPASSSSSTSDKEKVAKKGNSDATKSSTPEDLDAQLAHLPEHEREILKQQLFIPDAKATY 81
Query: 3714 PGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNA---LLVYPPTSKQFRNKA 3544
LFRY + D + L I ++ +I +G + P+ ++ G + + ++ T +F +
Sbjct: 82 GTLFRYATRNDMIFLAIVSLASIAAGAALPLFTVLFGSLAGTFRDIALHRITYDEFNSIL 141
Query: 3543 NENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFDKNHSGTI 3364
N F+ +GI I ++ + F + + ++R ++++++LRQN G+FDK +G +
Sbjct: 142 TRNSLYFVYLGIAQFILLYVSTVGFIYVGEHITQKIRAKYLHAILRQNIGFFDKLGAGEV 201
Query: 3363 TTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSL 3184
TT++ I++GI +K+G+ L + +A ++ Y+ W+LA + + M
Sbjct: 202 TTRITADTNLIQDGISEKVGLTLTALSTFFSAFIIGYVRYWKLALICSSTIVAMILVMGG 261
Query: 3183 LARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWK 3004
++R + + L+ G+ G++AEE + +R AF QE++ +YE L++ RK+
Sbjct: 262 ISRFVVKSGRMTLVSYGEGGTVAEEVISSIRNATAFGTQEKLARQYEVHLKEARKWGRRL 321
Query: 3003 XXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLISP 2824
G G G+ L VG T + +++++++G++ +G ++P
Sbjct: 322 QMMLGIMFGSMMAIMYSNYGLGFWMGSRFL-VGGETDLSAIVNILLAIVIGSFSIGNVAP 380
Query: 2823 HMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKIL 2644
+ +A + A I+ TIDRV IDP S G ++NV G ++F + YPSR + ++
Sbjct: 381 NTQAFASAISAGAKIFSTIDRVSAIDPGSDEGDTIENVEGTIEFRGIKHIYPSRPEVVVM 440
Query: 2643 NGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTV 2464
+NLVV G + ALVG SG GKST VGLL R Y P +G+V +DG D++ LN+ WLR +
Sbjct: 441 EDINLVVPKGKTTALVGPSGSGKSTVVGLLERFYNPVSGSVLLDGRDIKTLNLRWLRQQI 500
Query: 2463 GIVQQEPILFNDTIHNNLLIGNPGST---------RETMIEVCKMANAHDFIEKMPKGYD 2311
+V QEP LF TI N+ +G GS +E ++ K ANAHDFI +P GY
Sbjct: 501 SLVSQEPTLFGTTIFENIRLGLIGSPMENESEEQIKERIVSAAKEANAHDFIMGLPDGYA 560
Query: 2310 TLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRT 2131
T +G G LSGGQKQR+AIAR ++ DPK+LLLDEATSALD +SE +VQ+AL+ AS+GRT
Sbjct: 561 TDVGQRGFLLSGGQKQRIAIARAIVSDPKILLLDEATSALDTKSEGVVQAALDAASRGRT 620
Query: 2130 TIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKADPXXXXXX 1951
TI+IAHRLSTI+ AD IV G I E G H+ELV G Y LV+AQ+ +
Sbjct: 621 TIVIAHRLSTIKSADNIVVIVGGRIAEQGTHDELVDKKGTYLQLVEAQKINEERGEESE- 679
Query: 1950 XXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXXXXXXXXXXX 1771
D+ +++ G ++ +
Sbjct: 680 -------DEAVLEKEKEISRQISVPAKSVNSGKYPDEDVEANLGRIDTKKSLSSVILSQK 732
Query: 1770 XXXXEDGQITAGYLDIFKNA--KGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFV 1597
++ + + G L F K L M G FA++ G P ++ F +
Sbjct: 733 RSQEKETEYSLGTLIRFIAGFNKPERLIMLCGFFFAVLSGAGQPVQSVFFAKGITTLSLP 792
Query: 1596 P-YGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDA 1420
P G++ + F +G+ +Q A V+FA+ SE+L R R +SFR +L QD
Sbjct: 793 PSLYGKLREDANFWSLMFLMLGLVQLVTQSAQGVIFAICSESLIYRARSKSFRAMLRQDI 852
Query: 1419 SYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXX 1240
++FD P ++ G L + L+++ ++ V A + + + W+
Sbjct: 853 AFFDLPENSTGALTSFLSTETKHLSGVSGATLGTILMVSTTLIVALTVALAFGWK--LAL 910
Query: 1239 XXXXXXLAFVMIGLAYKISLMNVEQIQ----NDDAGRIAIEIIENVKTIQLLTRCELFFD 1072
++ G Y+ ++ Q + + + A E +++T+ LTR + +
Sbjct: 911 VCISTVPVLLLCGF-YRFWILAQFQTRAKKAYESSASYACEATSSIRTVASLTREQGVME 969
Query: 1071 HYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGI 892
Y+ Q + L+ ++ Y+ +QSF +F + + G ++ +G+ ++ F I
Sbjct: 970 IYEGQLNDQAKKSLRSVAKSSLLYAASQSFSFFCLALGFWYGGGLLGKGEYNAFQFFLCI 1029
Query: 891 IAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTG-DLMEGDRPE-IRGNILFE 718
++ G+ + + P+ KAK+AA + R P + +G++ E + G I F
Sbjct: 1030 SCVIFGSQSAGIVFSFSPDMGKAKSAAADFKRLFDRVPTIDIESTDGEKLETVEGTIEFR 1089
Query: 717 NVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDG 538
+V F YP RP QP+++GL T GQ +ALVGPSG GKST I ++ERFYD G + IDG
Sbjct: 1090 DVHFRYPTRPEQPVLRGLNLTVKPGQYIALVGPSGCGKSTTIALVERFYDTLSGGVYIDG 1149
Query: 537 QDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGL--KDVPLEKINQALELANANRFL 364
+DI +L++ R+ +ALV QEP L+ GTIR+NV LG+ DVP E++ A + AN F+
Sbjct: 1150 KDISRLNVNSYRSHLALVSQEPTLYQGTIRDNVLLGVDRDDVPDEQVFAACKAANIYDFI 1209
Query: 363 ANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEAL 184
+LP G T VG KG LSGGQKQRIAIARAL+RDPK+LLLDEATSALDSESE+ VQ AL
Sbjct: 1210 MSLPDGFGTVVGSKGSMLSGGQKQRIAIARALIRDPKVLLLDEATSALDSESEKVVQAAL 1269
Query: 183 DRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQDL 10
D A +GRT I +AHRLS+IQ +D+I D+G++ E+G H +L+ KGRYY+L+ Q L
Sbjct: 1270 DAAAKGRTTIAVAHRLSTIQKADIIYVFDQGRIVESGTHHELLQNKGRYYELVHMQSL 1327
Score = 359 bits (921), Expect = 3e-97
Identities = 224/657 (34%), Positives = 350/657 (53%), Gaps = 9/657 (1%)
Frame = -1
Query: 3921 STVLAIPALAVNDPKSDPKIASDLPANYVDDDDDAP--KMYTPSLLEKILNYALCRGDIA 3748
S +++PA +VN K Y D+D +A ++ T L ++
Sbjct: 691 SRQISVPAKSVNSGK------------YPDEDVEANLGRIDTKKSLSSVI-----LSQKR 733
Query: 3747 NQQLEAQPVSIPGLFRYGKKF---DYLLLFIGTICAIISGVSQPILALVSGRVTNALLVY 3577
+Q+ E + S+ L R+ F + L++ G A++SG QP+ ++ + L +
Sbjct: 734 SQEKETE-YSLGTLIRFIAGFNKPERLIMLCGFFFAVLSGAGQPVQSVFFAKGITTLSLP 792
Query: 3576 PPTSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNA 3397
P + R AN +FL +G+ +T Q + F C ++ + R + ++LRQ+
Sbjct: 793 PSLYGKLREDANFWSLMFLMLGLVQLVTQSAQGVIFAICSESLIYRARSKSFRAMLRQDI 852
Query: 3396 GWFD--KNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMM 3223
+FD +N +G +T+ L+ + + G LG +L LI A+ VA + W+LA +
Sbjct: 853 AFFDLPENSTGALTSFLSTETKHLSGVSGATLGTILMVSTTLIVALTVALAFGWKLALVC 912
Query: 3222 LGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYE 3043
+ P +C + + + S A E+ +RTV + ++ ++ YE
Sbjct: 913 ISTVPVLLLCGFYRFWILAQFQTRAKKAYESSASYACEATSSIRTVASLTREQGVMEIYE 972
Query: 3042 AELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMS 2863
+L K ++ G YG LL G F+ +
Sbjct: 973 GQLNDQAKKSLRSVAKSSLLYAASQSFSFFCLALGFWYGGGLLGKGEYNA-FQFFLCISC 1031
Query: 2862 MLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENV 2683
++ G+ G++ + A+ +AA + DRVP ID S G++L+ V G ++F +V
Sbjct: 1032 VIFGSQSAGIVFSFSPDMGKAKSAAADFKRLFDRVPTIDIESTDGEKLETVEGTIEFRDV 1091
Query: 2682 HFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTD 2503
HFRYP+R + +L GLNL V+PG +ALVG SGCGKST++ L+ R Y+ +G V IDG D
Sbjct: 1092 HFRYPTRPEQPVLRGLNLTVKPGQYIALVGPSGCGKSTTIALVERFYDTLSGGVYIDGKD 1151
Query: 2502 VRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIG--NPGSTRETMIEVCKMANAHDFIEK 2329
+ LN+ R+ + +V QEP L+ TI +N+L+G E + CK AN +DFI
Sbjct: 1152 ISRLNVNSYRSHLALVSQEPTLYQGTIRDNVLLGVDRDDVPDEQVFAACKAANIYDFIMS 1211
Query: 2328 MPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNN 2149
+P G+ T++G G LSGGQKQR+AIAR LIRDPKVLLLDEATSALD++SE +VQ+AL+
Sbjct: 1212 LPDGFGTVVGSKGSMLSGGQKQRIAIARALIRDPKVLLLDEATSALDSESEKVVQAALDA 1271
Query: 2148 ASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFK 1978
A+KGRTTI +AHRLSTI++AD I F++G IVE+G H EL++ GRY++LV Q +
Sbjct: 1272 AAKGRTTIAVAHRLSTIQKADIIYVFDQGRIVESGTHHELLQNKGRYYELVHMQSLE 1328
>gi|11038656|ref|NP_066302.1| ATP-binding cassette, sub-family B,
member 11; bile salt export pump; sister of
P-glycoprotein [Mus musculus]
gi|12643304|sp|Q9QY30|AB11_MOUSE Bile salt export pump (ATP-binding
cassette, sub-family B, member 11) (Sister of
P-glycoprotein)
gi|6502606|gb|AAF14372.1| liver bile salt export pump;
sister-of-p-glycoprotein [Mus musculus domesticus]
Length = 1321
Score = 709 bits (1830), Expect = 0.0
Identities = 433/1271 (34%), Positives = 672/1271 (52%), Gaps = 43/1271 (3%)
Frame = -1
Query: 3708 LFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQF--------- 3556
LFR+ D L+F+G++CA++ G++QP + +V G +T+ + Y ++
Sbjct: 50 LFRFSSSKDNWLMFMGSVCALLHGMAQPGMIIVFGILTDIFVEYDIERQELSIPGKVCMN 109
Query: 3555 ------RNKANENVY-------------------IFLGIGIFISITNFIQYMCFQHCCTR 3451
+ N+N+ I+ G+G+ + I + Q + R
Sbjct: 110 NTIVWINSSFNQNMTNGTSCGLVDINSEVIKFSGIYAGVGVAVLILGYFQIRLWVITGAR 169
Query: 3450 VMAQMRHRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIA 3271
+ +MR + ++R GWFD G + ++ +D + +I E I D++ + L+ + ++
Sbjct: 170 QIRKMRKFYFRRIMRMEIGWFDCTSVGELNSRFSDDINKIDEAIADQMALFLQRLSTALS 229
Query: 3270 AIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVR 3091
+++ + W+L ++L V+P I +++ + T EL KAGSIA+E L +R
Sbjct: 230 GLLLGFYRGWKLTLVILAVSPLIGIGAAVIGLSVAKFTELELKAYAKAGSIADEVLSSIR 289
Query: 3090 TVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLK 2911
TV AF G+ + V RYE L +++ +WK YG+ L+
Sbjct: 290 TVAAFGGENKEVERYEKNLMFAQRWGIWKGMVMGFFTGYMWCLIFFCYALAFWYGSRLVL 349
Query: 2910 VGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKA 2731
TPG + + + +++ A +G S + + +A+SI+QTIDR P +D S
Sbjct: 350 DEGEYTPGTLIQIFLCVIIAAMNIGNASSCLEIFSTGCSAASSIFQTIDRQPVMDCMSGD 409
Query: 2730 GKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLT 2551
G +L + G ++F NV F YPSR + KILN L++V++PG + A VG SG GKST++ L+
Sbjct: 410 GYKLDRIKGEIEFHNVTFHYPSRPEVKILNNLSMVIKPGETTAFVGSSGAGKSTALQLIQ 469
Query: 2550 RLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMI 2371
R Y+P G VT+DG D+R LNI WLR+ +GIV+QEP+LF+ TI N+ +G +T E ++
Sbjct: 470 RFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAENIRLGREEATMEDIV 529
Query: 2370 EVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSAL 2191
+ K ANA++FI +P+ +DTL+G+GG Q+SGGQKQRVAIAR LIR PK+LLLD ATSAL
Sbjct: 530 QAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQKQRVAIARALIRKPKILLLDMATSAL 589
Query: 2190 DAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGR 2011
D +SE+ VQ ALN G T I +AHRLST+R AD I+ FE G VE G HEEL+ G
Sbjct: 590 DNESEAKVQGALNKIQHGHTIISVAHRLSTVRSADVIIGFEHGTAVERGTHEELLERKGV 649
Query: 2010 YFDLVKAQQFKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFS 1831
YF LV Q + + + DT + +R S S
Sbjct: 650 YFMLVTLQSQEDNTHKETGIKGKDTTEGDTPERTFSRGSYQDSLRASIRQRSKSQLSHLS 709
Query: 1830 GSKRSXXXXXXXXXXXXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLE 1651
E+ + A I K + Y+ +G + A I G
Sbjct: 710 HEPPLAIGDHKSSYEDRKDNDVLVEEVE-PAPVRRILKYNISEWPYILVGALCAAINGAV 768
Query: 1650 LPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENL 1471
P +L+F + + F+ V + +M + F +G F+Q FA E L
Sbjct: 769 TPIYSLLFSQILKTFSLVDKEQQRSEIYSMCLF-FVILGCVSLFTQFLQGYNFAKSGELL 827
Query: 1470 SMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXX 1291
+ R R F+ +L QD +FD+ + PG L TRLA+DA ++ +++ +
Sbjct: 828 TKRLRKFGFKAMLRQDIGWFDDLKNNPGVLTTRLATDASQVQGATGSQVGMMVNSFTNIF 887
Query: 1290 XXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQN----DDAGRIAIEII 1123
++ W+ F+ + A + ++ Q+ + AG+I E +
Sbjct: 888 VAVLIAFLFNWK---LSLVISVFFPFLALSGAVQTKMLTGFASQDKEILEKAGQITNEAL 944
Query: 1122 ENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGI 943
N++T+ + F ++ ++ ++ ++K + + Y+ +Q + Y G
Sbjct: 945 SNIRTVAGIGVEGRFIKAFEVELEKSYKTAIRKANVYGLCYAFSQGISFLANSAAYRYGG 1004
Query: 942 RIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDL 763
+I D + F+ + ++ + A AV + Y P + KAK +A F ++ RKP D+
Sbjct: 1005 YLIVYEDLNFSYVFRVVSSIAMSATAVGRTFSYTPSYAKAKISAARFFQLLDRKPPI-DV 1063
Query: 762 MEGDRPE---IRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNI 592
G + +G I F + KF+YP RP ++ GL + GQT+A VG SG GKST+I
Sbjct: 1064 YSGAGEKWDNFQGKIDFIDCKFTYPSRPDIQVLNGLSVSVDPGQTLAFVGSSGCGKSTSI 1123
Query: 591 GMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG--LKDV 418
+LERFYD G + IDG D +K+++ LR+ + +V QEP LF +I +N+ G K++
Sbjct: 1124 QLLERFYDPDQGTVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFDCSIMDNIKYGDNTKEI 1183
Query: 417 PLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLD 238
+E+ A + A + F+ +LP +T+VG +G QLS G+KQRIAIARA+VRDPKILLLD
Sbjct: 1184 SVERAIAAAKQAQLHDFVMSLPEKYETNVGIQGSQLSRGEKQRIAIARAIVRDPKILLLD 1243
Query: 237 EATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQL 58
EATSALD+ESE+ VQ ALD+AREGRTCI IAHRLS+IQNSD+I + +G V E G H +L
Sbjct: 1244 EATSALDTESEKTVQLALDKAREGRTCIVIAHRLSTIQNSDIIAVMSQGVVIEKGTHKKL 1303
Query: 57 MHQKGRYYKLI 25
M QKG YYKL+
Sbjct: 1304 MDQKGAYYKLV 1314
Score = 373 bits (957), Expect = e-101
Identities = 208/587 (35%), Positives = 336/587 (56%), Gaps = 7/587 (1%)
Frame = -1
Query: 3735 EAQPVSIPGLFRYG-KKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQ 3559
E +P + + +Y ++ Y+L +G +CA I+G PI +L+ ++ + +Q
Sbjct: 735 EVEPAPVRRILKYNISEWPYIL--VGALCAAINGAVTPIYSLLFSQILKTFSLVD--KEQ 790
Query: 3558 FRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFD-- 3385
R++ F+ +G T F+Q F + ++R ++LRQ+ GWFD
Sbjct: 791 QRSEIYSMCLFFVILGCVSLFTQFLQGYNFAKSGELLTKRLRKFGFKAMLRQDIGWFDDL 850
Query: 3384 KNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPT 3205
KN+ G +TT+L +++ G ++G+++ F + A+++A+++ W+L+ ++ P
Sbjct: 851 KNNPGVLTTRLATDASQVQGATGSQVGMMVNSFTNIFVAVLIAFLFNWKLSLVISVFFPF 910
Query: 3204 CCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKG 3025
+ ++ + +T ++ + KAG I E+L +RTV + + +E ELEK
Sbjct: 911 LALSGAVQTKMLTGFASQDKEILEKAGQITNEALSNIRTVAGIGVEGRFIKAFEVELEKS 970
Query: 3024 RKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAY 2845
K A+ K YG YL+ + VF VV S+ + A
Sbjct: 971 YKTAIRKANVYGLCYAFSQGISFLANSAAYRYGGYLIVYEDLNF-SYVFRVVSSIAMSAT 1029
Query: 2844 FLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPS 2665
+G + A++SAA +Q +DR P ID YS AG++ N G++ F + F YPS
Sbjct: 1030 AVGRTFSYTPSYAKAKISAARFFQLLDRKPPIDVYSGAGEKWDNFQGKIDFIDCKFTYPS 1089
Query: 2664 RKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNI 2485
R D ++LNGL++ V+PG ++A VG SGCGKSTS+ LL R Y+P+ G V IDG D +++N+
Sbjct: 1090 RPDIQVLNGLSVSVDPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGTVMIDGHDSKKVNV 1149
Query: 2484 EWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIE----VCKMANAHDFIEKMPKG 2317
++LR+ +GIV QEP+LF+ +I +N+ G+ +T+E +E K A HDF+ +P+
Sbjct: 1150 QFLRSNIGIVSQEPVLFDCSIMDNIKYGD--NTKEISVERAIAAAKQAQLHDFVMSLPEK 1207
Query: 2316 YDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKG 2137
Y+T +G G QLS G+KQR+AIAR ++RDPK+LLLDEATSALD +SE VQ AL+ A +G
Sbjct: 1208 YETNVGIQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQLALDKAREG 1267
Query: 2136 RTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLV 1996
RT I+IAHRLSTI+ +D I +GV++E G H++L+ G Y+ LV
Sbjct: 1268 RTCIVIAHRLSTIQNSDIIAVMSQGVVIEKGTHKKLMDQKGAYYKLV 1314
Score = 276 bits (707), Expect = 2e-72
Identities = 193/617 (31%), Positives = 303/617 (48%), Gaps = 43/617 (6%)
Frame = -1
Query: 1737 GYLDIFK--NAKGNYLYMFLGTVFALIRGLELPALALIFG-------------------- 1624
G+ ++F+ ++K N+L MF+G+V AL+ G+ P + ++FG
Sbjct: 46 GFFELFRFSSSKDNWL-MFMGSVCALLHGMAQPGMIIVFGILTDIFVEYDIERQELSIPG 104
Query: 1623 ---------WVFEGFTFVPYGGRMMHRMAM--AVIAF----ASVGVGVWFSQLASSVLFA 1489
W+ F G + + VI F A VGV V L+
Sbjct: 105 KVCMNNTIVWINSSFNQNMTNGTSCGLVDINSEVIKFSGIYAGVGVAVLILGYFQIRLWV 164
Query: 1488 VVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXX 1309
+ + R FR ++ + +FD + G+L +R + D I + +M
Sbjct: 165 ITGARQIRKMRKFYFRRIMRMEIGWFD--CTSVGELNSRFSDDINKIDEAIADQMALFLQ 222
Query: 1308 XXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAF--VMIGLAYKISLMNVEQIQNDDAGRIA 1135
W+ + +IGL+ +E AG IA
Sbjct: 223 RLSTALSGLLLGFYRGWKLTLVILAVSPLIGIGAAVIGLSVA-KFTELELKAYAKAGSIA 281
Query: 1134 IEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTY 955
E++ +++T+ + Y+ + +R + KGM+ ++F +
Sbjct: 282 DEVLSSIRTVAAFGGENKEVERYEKNLMFAQRWGIWKGMVMGFFTGYMWCLIFFCYALAF 341
Query: 954 AVGIRIIY-QGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKP 778
G R++ +G+ + + + +++ A+ + N++ F +AA +F I R+P
Sbjct: 342 WYGSRLVLDEGEYTPGTLIQIFLCVIIAAMNIGNASSCLEIFSTGCSAASSIFQTIDRQP 401
Query: 777 RTGDLMEGDR---PEIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSG 607
D M GD I+G I F NV F YP RP I+ L G+T A VG SG+G
Sbjct: 402 -VMDCMSGDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNNLSMVIKPGETTAFVGSSGAG 460
Query: 606 KSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGL 427
KST + +++RFYD G + +DG DIR L++ LR Q+ +V QEP LF+ TI EN+ LG
Sbjct: 461 KSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAENIRLGR 520
Query: 426 KDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKIL 247
++ +E I QA + ANA F+ LP DT VGE GGQ+SGGQKQR+AIARAL+R PKIL
Sbjct: 521 EEATMEDIVQAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQKQRVAIARALIRKPKIL 580
Query: 246 LLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNH 67
LLD ATSALD+ESE VQ AL++ + G T I++AHRLS+++++D+I+ + G E G H
Sbjct: 581 LLDMATSALDNESEAKVQGALNKIQHGHTIISVAHRLSTVRSADVIIGFEHGTAVERGTH 640
Query: 66 TQLMHQKGRYYKLIKKQ 16
+L+ +KG Y+ L+ Q
Sbjct: 641 EELLERKGVYFMLVTLQ 657
>gi|31213429|ref|XP_315658.1| ENSANGP00000021663 [Anopheles gambiae]
gi|21299609|gb|EAA11754.1| ENSANGP00000021663 [Anopheles gambiae str.
PEST]
Length = 1243
Score = 707 bits (1826), Expect = 0.0
Identities = 425/1163 (36%), Positives = 627/1163 (53%), Gaps = 16/1163 (1%)
Frame = -1
Query: 3447 MAQMRHRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAA 3268
++++R F+ +VLRQ+ W+D N + ++ D +++++EGIG+KL + + +
Sbjct: 114 ISRIRQLFLKAVLRQDMTWYDLNSDDSFAVRITDDLDKLKEGIGEKLSIFTYLVMSFVIS 173
Query: 3267 IVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRT 3088
++ ++ Y W+L ++L AP + + +A+ ++ T KEL AG++AEE L +RT
Sbjct: 174 VIFSFFYGWKLTLVILSCAPIIILATAFVAKMQSTLTEKELKSYSSAGAVAEEVLGSIRT 233
Query: 3087 VQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLL-- 2914
V AF G+++ RY L K YG L+
Sbjct: 234 VVAFGGEKKEADRYRERLAGAELNGRRKGLFSGIGGGIMWFIIYCCYALAFWYGISLILE 293
Query: 2913 ---KVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDP 2743
K TP + IV+ +L GA LGL SPH+ A+ SAA+I+ IDR+P ID
Sbjct: 294 DRDKDLKDYTPAVLIIVLFGVLAGAQNLGLSSPHLEAFSTAKGSAATIFSVIDRIPVIDS 353
Query: 2742 YSKAGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSV 2563
AG R ++ G +KF NV FRYP+R D ++L GLNL ++ G +VALVG SGCGKST +
Sbjct: 354 LGDAGLRPGSMQGNIKFSNVFFRYPARNDVQVLQGLNLEIKTGQTVALVGPSGCGKSTCL 413
Query: 2562 GLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTR 2383
L+ RLY+P +G+VTIDGT V ELNI WLR+ +G+V QEP+LF TI N+ GNP +++
Sbjct: 414 QLIQRLYDPLSGSVTIDGTKVSELNIGWLRSFIGLVGQEPVLFATTIAENIRYGNPDASQ 473
Query: 2382 ETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEA 2203
+ K+AN H FI K+P GY T+IG+ G QLSGGQKQR+AIAR L+R+PK+LLLDEA
Sbjct: 474 SEIERAAKIANCHSFITKLPNGYATMIGERGAQLSGGQKQRIAIARALVRNPKILLLDEA 533
Query: 2202 TSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVR 2023
TSALD SE VQ AL ASKGRTT++++HRLSTI ADKIV+ +KG+++E G HEEL+
Sbjct: 534 TSALDPNSEKRVQDALERASKGRTTLVVSHRLSTITNADKIVYIDKGLVMEQGTHEELMA 593
Query: 2022 LGGRYFDLVKAQQFKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLN 1843
G Y+DLV A +D D++ + + +
Sbjct: 594 ARGLYYDLVVA-----------SGSQKTVDDDESVPMAPSALSMRQESVDDGAEASDDES 642
Query: 1842 DSFSGSKRSXXXXXXXXXXXXXXXXXXXEDGQITAGYLDIFKNAKGN---YLYMFLGTVF 1672
DS +++ E+ Q ++ + + K N + Y+ G
Sbjct: 643 DSGKSDEKN-------------------EEEQEEVYHVSLMRLLKLNAPEWHYILFGCAA 683
Query: 1671 ALIRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLF 1492
A++ G PA A++FG ++ G V + F +G+ + LF
Sbjct: 684 AIVVGASFPAFAVLFGEMY-GILSVADPEYVKEESNFYSFLFLVLGLITGVGTFFQTYLF 742
Query: 1491 AVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVX 1312
+ L+ R R +SF+ ++ QD ++FD +A G L RL+ D +++ R+ +
Sbjct: 743 NIAGVRLTSRLRQKSFKAIVSQDMAWFDESRNAVGALCARLSGDCASVQGATGTRIGSLL 802
Query: 1311 XXXXXXXXXXXXXXIYCWQXXXXXXXXX-XXLAFVMIGLAYKISLMNVEQIQNDDAGRIA 1135
Y W LA + + Y + E+ + A ++A
Sbjct: 803 QAASTICIGVGISFFYSWNLTLVSIIAIPVTLASITLESRYSQTSSLKEKQSQEGATKLA 862
Query: 1134 IEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTY 955
+E I N++T+ L + + Y + + + +K + ++L Q +
Sbjct: 863 VEAISNIRTVASLGQEKHVLQRYGEETVKIDDACRRKTRLRGTVFALGQVMPFAGYGLAL 922
Query: 954 AVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPR 775
G +++ + + D K A++ GA + + Y P A +AG L ++ R PR
Sbjct: 923 FYGGKLVSEKELEYKDVIKVSEALIFGAWMLGQALAYAPNVNSAILSAGRLMKLLDRTPR 982
Query: 774 -----TGDLMEGDRPEIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGS 610
T R E G+I F +V+F YP RP P+++GL +GQTVALVGPSG
Sbjct: 983 MHNPSTSYHSLSQRTE--GDIKFTDVEFRYPTRPTVPVLQGLNLDIGKGQTVALVGPSGC 1040
Query: 609 GKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG 430
GKST I +L R+YD G + IDG + SL +R QM LV QEP LF TI EN+ G
Sbjct: 1041 GKSTCIQLLLRYYDPDSGKVDIDGTTTTEFSLNRIRAQMGLVSQEPILFDRTIAENIAYG 1100
Query: 429 --LKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDP 256
+++ + +I +A ++AN + F+ NLP G DT +G KG QLSGGQKQRIAIARALVR+P
Sbjct: 1101 DNTREIAMPEIMEAAKMANIHEFIVNLPKGYDTSLGSKGAQLSGGQKQRIAIARALVRNP 1160
Query: 255 KILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEA 76
++LLLDEATSALD++SE+ VQ ALD AR GRTCI IAHRL++IQN++LI I G V EA
Sbjct: 1161 RVLLLDEATSALDNQSEKIVQNALDHARTGRTCIIIAHRLTTIQNANLICVIQNGVVVEA 1220
Query: 75 GNHTQLMHQKGRYYKLIKKQDLA 7
G H +LM + Y KL + Q +A
Sbjct: 1221 GTHDELMAKSRIYAKLYQMQQVA 1243
Score = 346 bits (887), Expect = 3e-93
Identities = 221/639 (34%), Positives = 344/639 (53%), Gaps = 21/639 (3%)
Frame = -1
Query: 3837 VDDDDDAPKMYTPSLL----EKILNYALCRGDIAN----------QQLEAQPVSIPGLFR 3700
VDDD+ P PS L E + + A D ++ +Q E VS+ L +
Sbjct: 611 VDDDESVPM--APSALSMRQESVDDGAEASDDESDSGKSDEKNEEEQEEVYHVSLMRLLK 668
Query: 3699 YGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKANENVYIFL 3520
+ +LF G AI+ G S P A++ G + L V P + + ++N ++FL
Sbjct: 669 LNAPEWHYILF-GCAAAIVVGASFPAFAVLFGEMYGILSVADP--EYVKEESNFYSFLFL 725
Query: 3519 GIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFD--KNHSGTITTKLND 3346
+G+ + F Q F R+ +++R + +++ Q+ WFD +N G + +L+
Sbjct: 726 VLGLITGVGTFFQTYLFNIAGVRLTSRLRQKSFKAIVSQDMAWFDESRNAVGALCARLSG 785
Query: 3345 SMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMT 3166
++ G ++G LL+ + + + +++ Y W L + + P ++L +R
Sbjct: 786 DCASVQGATGTRIGSLLQAASTICIGVGISFFYSWNLTLVSIIAIPVTLASITLESRYSQ 845
Query: 3165 STTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXX 2986
++++KE A +A E++ +RTV + ++ ++ RY E K K
Sbjct: 846 TSSLKEKQSQEGATKLAVEAISNIRTVASLGQEKHVLQRYGEETVKIDDACRRKTRLRGT 905
Query: 2985 XXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLL 2806
G + YG L+ + DV V +++ GA+ LG + +
Sbjct: 906 VFALGQVMPFAGYGLALFYGGKLVSEKELEYK-DVIKVSEALIFGAWMLGQALAYAPNVN 964
Query: 2805 NARVSAASIYQTIDRVPKI-DPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNL 2629
+A +SA + + +DR P++ +P + Q G +KF +V FRYP+R +L GLNL
Sbjct: 965 SAILSAGRLMKLLDRTPRMHNPSTSYHSLSQRTEGDIKFTDVEFRYPTRPTVPVLQGLNL 1024
Query: 2628 VVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQ 2449
+ G +VALVG SGCGKST + LL R Y+P++G V IDGT E ++ +R +G+V Q
Sbjct: 1025 DIGKGQTVALVGPSGCGKSTCIQLLLRYYDPDSGKVDIDGTTTTEFSLNRIRAQMGLVSQ 1084
Query: 2448 EPILFNDTIHNNLLIGNPGSTRET----MIEVCKMANAHDFIEKMPKGYDTLIGDGGVQL 2281
EPILF+ TI N+ G+ +TRE ++E KMAN H+FI +PKGYDT +G G QL
Sbjct: 1085 EPILFDRTIAENIAYGD--NTREIAMPEIMEAAKMANIHEFIVNLPKGYDTSLGSKGAQL 1142
Query: 2280 SGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLST 2101
SGGQKQR+AIAR L+R+P+VLLLDEATSALD QSE IVQ+AL++A GRT I+IAHRL+T
Sbjct: 1143 SGGQKQRIAIARALVRNPRVLLLDEATSALDNQSEKIVQNALDHARTGRTCIIIAHRLTT 1202
Query: 2100 IREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQ 1984
I+ A+ I + GV+VEAG H+EL+ Y L + QQ
Sbjct: 1203 IQNANLICVIQNGVVVEAGTHDELMAKSRIYAKLYQMQQ 1241
Score = 285 bits (728), Expect = 8e-75
Identities = 181/508 (35%), Positives = 276/508 (53%), Gaps = 9/508 (1%)
Frame = -1
Query: 1521 FSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKA 1342
F+ L+ V+ + +S R R + +L QD +++D ++ R+ D +K
Sbjct: 98 FATLSVDVINRSAQKQIS-RIRQLFLKAVLRQDMTWYD--LNSDDSFAVRITDDLDKLKE 154
Query: 1341 VVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQI 1162
+ ++ Y W+ + +A S + +++
Sbjct: 155 GIGEKLSIFTYLVMSFVISVIFSFFYGWKLTLVILSCAPIIILATAFVAKMQSTLTEKEL 214
Query: 1161 QN-DDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQS 985
++ AG +A E++ +++T+ + D Y+ + + +KG+ I +
Sbjct: 215 KSYSSAGAVAEEVLGSIRTVVAFGGEKKEADRYRERLAGAELNGRRKGLFSGIGGGIMWF 274
Query: 984 FMYFMMCFTYAVGIRIIYQG-DKSSDDTFKGIIAMML-----GAVAVMNSAQYFPEFVKA 823
+Y + GI +I + DK D ++ ++L GA + S+ + F A
Sbjct: 275 IIYCCYALAFWYGISLILEDRDKDLKDYTPAVLIIVLFGVLAGAQNLGLSSPHLEAFSTA 334
Query: 822 KTAAGMLFNIIYRKPRTGDLME-GDRP-EIRGNILFENVKFSYPQRPLQPIMKGLQWTAL 649
K +A +F++I R P L + G RP ++GNI F NV F YP R +++GL
Sbjct: 335 KGSAATIFSVIDRIPVIDSLGDAGLRPGSMQGNIKFSNVFFRYPARNDVQVLQGLNLEIK 394
Query: 648 RGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPR 469
GQTVALVGPSG GKST + +++R YD G++ IDG + +L++ LR+ + LVGQEP
Sbjct: 395 TGQTVALVGPSGCGKSTCLQLIQRLYDPLSGSVTIDGTKVSELNIGWLRSFIGLVGQEPV 454
Query: 468 LFAGTIRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQR 289
LFA TI EN+ G D +I +A ++AN + F+ LP G T +GE+G QLSGGQKQR
Sbjct: 455 LFATTIAENIRYGNPDASQSEIERAAKIANCHSFITKLPNGYATMIGERGAQLSGGQKQR 514
Query: 288 IAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLI 109
IAIARALVR+PKILLLDEATSALD SE+ VQ+AL+RA +GRT + ++HRLS+I N+D I
Sbjct: 515 IAIARALVRNPKILLLDEATSALDPNSEKRVQDALERASKGRTTLVVSHRLSTITNADKI 574
Query: 108 VYIDKGKVQEAGNHTQLMHQKGRYYKLI 25
VYIDKG V E G H +LM +G YY L+
Sbjct: 575 VYIDKGLVMEQGTHEELMAARGLYYDLV 602
>gi|18496818|gb|AAL74250.1| ABC transporter AbcB3 [Dictyostelium
discoideum]
Length = 1432
Score = 707 bits (1825), Expect = 0.0
Identities = 434/1297 (33%), Positives = 671/1297 (51%), Gaps = 63/1297 (4%)
Frame = -1
Query: 3729 QPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRN 3550
Q V LFR+ D +L+F+GTI A+I+G + P ++LV G V +A + PT QF +
Sbjct: 161 QSVPFLSLFRFADNTDKVLMFLGTIAAVINGAAMPTVSLVFGLVVDA---FKPT--QFND 215
Query: 3549 KANENVY----------IFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQN 3400
N ++Y + LG G+F+ ++++ + R +++R ++ S LRQ
Sbjct: 216 DPNYDIYDTVRSISFYLLMLGGGVFV--LSYLETTLWMIAGERQTSRIRREYLESTLRQE 273
Query: 3399 AGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMML 3220
GWFD N + +++++N E IG+K+G + F+ +A V+ + W+L ++
Sbjct: 274 IGWFDTNKANELSSRINSDTVLFEEAIGEKVGRFIHFFSTFVAGFVIGFTKGWQLTLVIT 333
Query: 3219 GVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEA 3040
V+P I A+ MT T +AG +AEE++ +RTV F+G++ + +Y
Sbjct: 334 SVSPLLAIGGFFTAKMMTQMTKLGQEAYSRAGGVAEENIGSIRTVATFSGEKLAIDKYSN 393
Query: 3039 ELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIIT-------TPGDV 2881
L+ R + YG+ L+ + T GDV
Sbjct: 394 NLKDARTVGYKRSFFNGLGLGFVQFVILGTYALAFWYGSTLISNKVTNSVSDRPWTGGDV 453
Query: 2880 FIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGR 2701
V ++++GA +G SP + + R +A I+Q IDR K +P+S G + + + G
Sbjct: 454 VSVFFAVIIGATSIGQASPCLALFAQGRGAAYKIFQVIDRQSKANPFSTRGIKPETLSGE 513
Query: 2700 VKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNV 2521
++F++V F YPSR D I NG NL ++PG +V LVG SG GKST + LL R Y+P G +
Sbjct: 514 IEFKDVGFHYPSRPDVPIFNGFNLKIKPGQTVGLVGDSGGGKSTIISLLERFYDPCQGEI 573
Query: 2520 TIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHD 2341
+DG D+R+ N+ LR +G+V QEP+LF TI N+ G G+T++ + E K+ANAH
Sbjct: 574 LLDGEDIRKFNVRGLRQKIGLVNQEPVLFATTISENIRYGKEGATQDEIEEAAKLANAHS 633
Query: 2340 FIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQS 2161
FI ++P+GY+TL+G+ GVQ+SGGQ+QR+AIAR +I++P +LLLDE+TSALDA+S +VQ
Sbjct: 634 FISQLPQGYNTLVGEKGVQMSGGQRQRIAIARAVIKNPNILLLDESTSALDAESTKLVQE 693
Query: 2160 ALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQF 1981
AL+ KGRTTI+IAH LSTIR AD I++ +KGV VE G H+EL+ G YFDLV+ Q
Sbjct: 694 ALDVLMKGRTTIVIAHNLSTIRNADVIIYIKKGVAVERGTHDELMAKQGLYFDLVEKQSH 753
Query: 1980 KADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXX 1801
+ +L + N L DSF SKRS
Sbjct: 754 Q-----------QMYNLLENGTRSRRSSTFSAEV--------NPLLDSFHVSKRSLRKNE 794
Query: 1800 XXXXXXXXXXXXXXEDGQITAGYLD------IFKNAKGNYLYMFLGTVFALIRGLELPAL 1639
+ + ++ + K + G + A+ G P
Sbjct: 795 SESNKKDKEDSNNKKKKKSNKKKVEEVPMSRVVKYNRPELGLWCFGFLSAVGTGAVYPGF 854
Query: 1638 ALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRF 1459
A++F + F P + + F ++ VG S LF+V+ E L+ R
Sbjct: 855 AMVFTEMLTIFQ-NPDPNYLTDHANFVALMFVALAVGAGISNFFQGFLFSVIGEKLTYRL 913
Query: 1458 RVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXX 1279
R F ++ QD +FD P ++ GKL + LA+DA ++ + R+ V
Sbjct: 914 RRDCFAAIMRQDVGWFDLPENSTGKLTSHLATDAALVQGMTSQRLGIVLQNILTMVGGLV 973
Query: 1278 XXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQNDD----AGRIAIEIIENVK 1111
WQ F ++ + K+ + + + D AG++A E I ++
Sbjct: 974 IAFYSGWQ-----LTLVIIACFPLVVITSKVQMQILAGFSSKDGCGPAGQVASEAISGIR 1028
Query: 1110 TIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIY 931
T+ T + + Y+ K +KK I + TQ ++ + C ++ G +++
Sbjct: 1029 TVASFTTEKQVVELYKKQQKGPSSEGIKKAHISGFAFGFTQLILFCVYCLSFWYGGKLVG 1088
Query: 930 QG-----DKSSDD----------------------TFKG-------IIAMMLGAVAVMNS 853
G DK D T G A+++ A+ V +
Sbjct: 1089 SGVFGATDKEISDNCTPQTIPYLWKDYDTCERAQNTIYGFNSMTRVFFAIVMSAIGVGQA 1148
Query: 852 AQYFPEFVKAKTAAGMLFNIIYRKPRTGDLME-GDRPEI-RGNILFENVKFSYPQRPLQP 679
+ + P+ KAK AA +F ++ + E GDR +I G+I F+N+ FSYP RP
Sbjct: 1149 SSFAPDLAKAKAAAVSVFKLLDTPSKIDPTTEDGDRIDIVGGDIEFKNLHFSYPTRPDNS 1208
Query: 678 IMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRT 499
+ +G T G T ALVG SG GKST + +L+RFY+ G + IDG +I+ L++ HLR
Sbjct: 1209 VFRGFTLTLQSGTTTALVGDSGGGKSTCLSLLQRFYNPVVGEIFIDGHNIKNLNVRHLRH 1268
Query: 498 QMALVGQEPRLFAGTIRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGEKG 319
LVGQEP LF+GTI +N+ G D E+I +A +L+N++ F+ +LP G +T++GEK
Sbjct: 1269 LFGLVGQEPTLFSGTIADNIRYGKHDATQEEIEEASKLSNSHSFIIDLPNGYNTELGEKY 1328
Query: 318 GQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHR 139
QLSGGQKQRIAIARA++R+PKILLLDE+TSALD++S + VQEAL+ +GRT I IAH
Sbjct: 1329 TQLSGGQKQRIAIARAIIRNPKILLLDESTSALDADSTKLVQEALENVMKGRTTIVIAHN 1388
Query: 138 LSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKL 28
L +IQN+D I Y+ G++ E G H +L+ +G Y +L
Sbjct: 1389 LLTIQNADCIAYVRAGQIIERGTHDELLEAEGPYSQL 1425
Score = 329 bits (844), Expect = 3e-88
Identities = 196/598 (32%), Positives = 312/598 (51%), Gaps = 36/598 (6%)
Frame = -1
Query: 3663 GTICAIISGVSQPILALVSGRVTNALLVYP-PTSKQFRNKANENVYIFLGIGIFISITNF 3487
G + A+ +G P A+V T L ++ P + AN +F+ + + I+NF
Sbjct: 840 GFLSAVGTGAVYPGFAMV---FTEMLTIFQNPDPNYLTDHANFVALMFVALAVGAGISNF 896
Query: 3486 IQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFD--KNHSGTITTKLNDSMERIREGIGD 3313
Q F ++ ++R +++RQ+ GWFD +N +G +T+ L ++
Sbjct: 897 FQGFLFSVIGEKLTYRLRRDCFAAIMRQDVGWFDLPENSTGKLTSHLATDAALVQGMTSQ 956
Query: 3312 KLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVG 3133
+LG++L+ ++ +V+A+ W+L +++ P I + + + + K+ G G
Sbjct: 957 RLGIVLQNILTMVGGLVIAFYSGWQLTLVIIACFPLVVITSKVQMQILAGFSSKD--GCG 1014
Query: 3132 KAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXX 2953
AG +A E++ G+RTV +F ++++V Y+ + + + K
Sbjct: 1015 PAGQVASEAISGIRTVASFTTEKQVVELYKKQQKGPSSEGIKKAHISGFAFGFTQLILFC 1074
Query: 2952 XXGCGMLYGAYLLKVGII--------------TTP-------------------GDVFIV 2872
YG L+ G+ T P + V
Sbjct: 1075 VYCLSFWYGGKLVGSGVFGATDKEISDNCTPQTIPYLWKDYDTCERAQNTIYGFNSMTRV 1134
Query: 2871 VMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKF 2692
++++ A +G S L A+ +A S+++ +D KIDP ++ G R+ V G ++F
Sbjct: 1135 FFAIVMSAIGVGQASSFAPDLAKAKAAAVSVFKLLDTPSKIDPTTEDGDRIDIVGGDIEF 1194
Query: 2691 ENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTID 2512
+N+HF YP+R D + G L ++ GT+ ALVG SG GKST + LL R Y P G + ID
Sbjct: 1195 KNLHFSYPTRPDNSVFRGFTLTLQSGTTTALVGDSGGGKSTCLSLLQRFYNPVVGEIFID 1254
Query: 2511 GTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIE 2332
G +++ LN+ LR+ G+V QEP LF+ TI +N+ G +T+E + E K++N+H FI
Sbjct: 1255 GHNIKNLNVRHLRHLFGLVGQEPTLFSGTIADNIRYGKHDATQEEIEEASKLSNSHSFII 1314
Query: 2331 KMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALN 2152
+P GY+T +G+ QLSGGQKQR+AIAR +IR+PK+LLLDE+TSALDA S +VQ AL
Sbjct: 1315 DLPNGYNTELGEKYTQLSGGQKQRIAIARAIIRNPKILLLDESTSALDADSTKLVQEALE 1374
Query: 2151 NASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFK 1978
N KGRTTI+IAH L TI+ AD I + G I+E G H+EL+ G Y L QQ K
Sbjct: 1375 NVMKGRTTIVIAHNLLTIQNADCIAYVRAGQIIERGTHDELLEAEGPYSQLWYNQQQK 1432
Score = 305 bits (782), Expect = 4e-81
Identities = 202/593 (34%), Positives = 314/593 (52%), Gaps = 20/593 (3%)
Frame = -1
Query: 1734 YLDIFKNAKG-NYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMA 1558
+L +F+ A + + MFLGT+ A+I G +P ++L+FG V + F + + +
Sbjct: 165 FLSLFRFADNTDKVLMFLGTIAAVINGAAMPTVSLVFGLVVDAFKPTQFNDDPNYDIYDT 224
Query: 1557 VIAFA----SVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAP 1390
V + + +G GV+ + L+ + E + R R + + L Q+ +FD +
Sbjct: 225 VRSISFYLLMLGGGVFVLSYLETTLWMIAGERQTSRIRREYLESTLRQEIGWFDT--NKA 282
Query: 1389 GKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFV 1210
+L +R+ SD + + ++ + WQ LA
Sbjct: 283 NELSSRINSDTVLFEEAIGEKVGRFIHFFSTFVAGFVIGFTKGWQLTLVITSVSPLLAIG 342
Query: 1209 MIGLAYKISLMN-VEQIQNDDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSE 1033
A ++ M + Q AG +A E I +++T+ + +L D Y + K +
Sbjct: 343 GFFTAKMMTQMTKLGQEAYSRAGGVAEENIGSIRTVATFSGEKLAIDKYSNNLKDARTVG 402
Query: 1032 LKKGMIEAINYSLTQSFMYFMMCFTYAV----GIRIIYQGDKSS--------DDTFKGII 889
K+ + F+ F++ TYA+ G +I +S D
Sbjct: 403 YKRSFFNGLGLG----FVQFVILGTYALAFWYGSTLISNKVTNSVSDRPWTGGDVVSVFF 458
Query: 888 AMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLM-EGDRPE-IRGNILFEN 715
A+++GA ++ ++ F + + AA +F +I R+ + G +PE + G I F++
Sbjct: 459 AVIIGATSIGQASPCLALFAQGRGAAYKIFQVIDRQSKANPFSTRGIKPETLSGEIEFKD 518
Query: 714 VKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQ 535
V F YP RP PI G GQTV LVG SG GKST I +LERFYD G + +DG+
Sbjct: 519 VGFHYPSRPDVPIFNGFNLKIKPGQTVGLVGDSGGGKSTIISLLERFYDPCQGEILLDGE 578
Query: 534 DIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGLKDVPLEKINQALELANANRFLANL 355
DIRK ++ LR ++ LV QEP LFA TI EN+ G + ++I +A +LANA+ F++ L
Sbjct: 579 DIRKFNVRGLRQKIGLVNQEPVLFATTISENIRYGKEGATQDEIEEAAKLANAHSFISQL 638
Query: 354 PAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRA 175
P G +T VGEKG Q+SGGQ+QRIAIARA++++P ILLLDE+TSALD+ES + VQEALD
Sbjct: 639 PQGYNTLVGEKGVQMSGGQRQRIAIARAVIKNPNILLLDESTSALDAESTKLVQEALDVL 698
Query: 174 REGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQ 16
+GRT I IAH LS+I+N+D+I+YI KG E G H +LM ++G Y+ L++KQ
Sbjct: 699 MKGRTTIVIAHNLSTIRNADVIIYIKKGVAVERGTHDELMAKQGLYFDLVEKQ 751
>gi|7514034|pir||T42228 P-glycoprotein sister - rat
gi|3273484|gb|AAC24753.1| P-glycoprotein sister [Rattus norvegicus]
Length = 1321
Score = 704 bits (1818), Expect = 0.0
Identities = 438/1295 (33%), Positives = 668/1295 (50%), Gaps = 67/1295 (5%)
Frame = -1
Query: 3708 LFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQF--------- 3556
LFR+ D L+ +G +CA++ G++QP + ++ G +T+ + Y ++
Sbjct: 50 LFRFSSSKDIWLMLMGGVCALLHGMAQPGILIIFGIMTDIFIKYDIERQELEIPGKACVN 109
Query: 3555 -----------RNKANENVY--------------IFLGIGIFISITNFIQYMCFQHCCTR 3451
+N N V I+ G+G+ + I + Q + R
Sbjct: 110 NTIVWINSSFHQNMTNGTVCGLVDIESEMIKFSGIYAGVGMTVLILGYFQIRLWVITGAR 169
Query: 3450 VMAQMRHRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIA 3271
+ +MR + ++R GWFD G + ++ D +E+I + I D+L L+ + +
Sbjct: 170 QIRRMRKIYFRRIMRMEIGWFDCTSVGELNSRFADDIEKINDAIADQLAHFLQRMSTAMC 229
Query: 3270 AIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVR 3091
+++ + W+L ++L V+P I +++ + T EL KAGSIA+E L +R
Sbjct: 230 GLLLGFYRGWKLTLVILAVSPLIGIGAAVIGLSIAKFTELELKAYAKAGSIADEVLSSIR 289
Query: 3090 TVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLK 2911
TV AF G+ + V RYE L +++ +WK YG+ L+
Sbjct: 290 TVAAFGGENKEVERYEKNLVFAQRWGIWKGMVMGFFTGYMWCLIFFCYALAFWYGSTLVL 349
Query: 2910 VGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKA 2731
TPG + + + ++L A +G S + + +A +I+QTIDR P ID S
Sbjct: 350 DEEEYTPGTLVQIFLCVILAAMNIGHASSCLEIFSTGCSAATNIFQTIDRQPVIDCMSGD 409
Query: 2730 GKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLT 2551
G +L + G ++F NV F YPSR D KIL+ L++V++PG + ALVG SG GKST++ L+
Sbjct: 410 GYKLDRIKGEIEFHNVTFHYPSRPDVKILDNLSMVIKPGETTALVGSSGAGKSTALQLIQ 469
Query: 2550 RLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMI 2371
R Y+P G VT+DG D+R LNI WLR+ +GIV+QEP+LF+ TI N+ G +T E ++
Sbjct: 470 RFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAENIRFGREDATMEDIV 529
Query: 2370 EVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSAL 2191
+ K ANA++FI +P+ +DTL+G+GG Q+SGGQKQRVAIAR LIR+PK+LLLD ATSAL
Sbjct: 530 QAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSAL 589
Query: 2190 DAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGR 2011
D +SE+ VQ ALN G T I +AHRLST+R AD I+ FE GV VE G HEEL+ G
Sbjct: 590 DNESEARVQEALNKIQHGHTIISVAHRLSTVRAADVIIGFEHGVAVERGTHEELLERKGV 649
Query: 2010 YFDLVKAQQFKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFS 1831
YF LV Q + D T G +L +FS
Sbjct: 650 YFMLVTLQ----SQGDNAHKETSIMGKDAT--------------------EGGTLERTFS 685
Query: 1830 -GSKRSXXXXXXXXXXXXXXXXXXXEDGQITAGYLDIFKNAKGN---------------- 1702
GS R + A + +K++K N
Sbjct: 686 RGSYRDSLRASIRQRSKSQLSLLTHDPPLAVADHKSSYKDSKDNDVLVEEVEPAPVRRIL 745
Query: 1701 ------YLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGRM--MHRMAMAVIAF 1546
+ Y+ +G++ A I G P +L+F + F+ + + +H M + +
Sbjct: 746 KYNIPEWHYILVGSLSAAINGAVTPIYSLLFSQLLGTFSLLDKEQQRSEIHSMCLFFVIL 805
Query: 1545 ASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLA 1366
V + F+Q FA E L+ R R F+ +L QD +FD+ + PG L TRLA
Sbjct: 806 GCVSI---FTQFLQGYTFAKSGELLTKRLRKFGFKAMLGQDIGWFDDLRNNPGVLTTRLA 862
Query: 1365 SDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKI 1186
+DA ++ +++ + + W+ F+ + A +
Sbjct: 863 TDASQVQGATGSQVGMMVNSFTNIIAALLIAFFFSWK---LSLIITIFFPFLALSGAVQT 919
Query: 1185 SLMNVEQIQN----DDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGM 1018
++ Q+ + AG+I E + N++T+ + F ++ + ++ ++K
Sbjct: 920 KMLTGFASQDKQALEKAGQITSEALSNIRTVAGIGVEGRFIKAFEVELQTSYKTAVRKAN 979
Query: 1017 IEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFP 838
I + ++ +Q + Y G +I F+ + +++L A AV + Y P
Sbjct: 980 IYGLCFAFSQGIAFLANSAAYRYGGYLIAYEGLGFSHVFRVVSSVVLSATAVGRTFSYTP 1039
Query: 837 EFVKAKTAAGMLFNIIYRKPRTGDLMEGDR--PEIRGNILFENVKFSYPQRPLQPIMKGL 664
+ KAK +A F ++ RKP E +G I F + KF+YP RP ++ GL
Sbjct: 1040 SYAKAKISAARFFQLLDRKPPINVYSEAGEKWDNFQGKIDFIDCKFTYPSRPDIQVLNGL 1099
Query: 663 QWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALV 484
+ GQT+A VG SG GKST+I +LERFYD G + IDG D +K+++ LR+ + +V
Sbjct: 1100 SVSVNPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGTVMIDGHDSKKVNIQFLRSNIGIV 1159
Query: 483 GQEPRLFAGTIRENVCLG--LKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQL 310
QEP LF +I +N+ G K++ +E+ A + A + F+ +LP +T+VG +G QL
Sbjct: 1160 SQEPVLFDCSIMDNIKYGDNTKEISVERAIAAAKQAQLHDFVMSLPEKYETNVGIQGSQL 1219
Query: 309 SGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSS 130
S G+KQRIAIARA+VRDPKILLLDEATSALD+ESE+ VQ ALD+AREGRTCI IAHRLS+
Sbjct: 1220 SRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQTALDKAREGRTCIVIAHRLST 1279
Query: 129 IQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLI 25
IQNSD+I + +G V E G H +LM QKG YYKL+
Sbjct: 1280 IQNSDIIAVVSQGVVIEKGTHEKLMAQKGAYYKLV 1314
Score = 372 bits (955), Expect = e-101
Identities = 226/655 (34%), Positives = 360/655 (54%), Gaps = 6/655 (0%)
Frame = -1
Query: 3942 QRRPSQRSTVLAIPALAVNDPKSDPKIASDLPANYVDDDDDAPKMYTPSLLEKILNYALC 3763
QR SQ S + P LAV D KS K + D +D + P+ + +IL Y
Sbjct: 699 QRSKSQLSLLTHDPPLAVADHKSSYKDSKD--------NDVLVEEVEPAPVRRILKY--- 747
Query: 3762 RGDIANQQLEAQPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALL 3583
+IP ++ Y+L +G++ A I+G PI +L+ ++
Sbjct: 748 --------------NIP-------EWHYIL--VGSLSAAINGAVTPIYSLLFSQLLGTFS 784
Query: 3582 VYPPTSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQ 3403
+ +Q R++ + F+ +G T F+Q F + ++R ++L Q
Sbjct: 785 LLD--KEQQRSEIHSMCLFFVILGCVSIFTQFLQGYTFAKSGELLTKRLRKFGFKAMLGQ 842
Query: 3402 NAGWFD--KNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLAS 3229
+ GWFD +N+ G +TT+L +++ G ++G+++ F +IAA+++A+ + W+L+
Sbjct: 843 DIGWFDDLRNNPGVLTTRLATDASQVQGATGSQVGMMVNSFTNIIAALLIAFFFSWKLSL 902
Query: 3228 MMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGR 3049
++ P + ++ + +T ++ + KAG I E+L +RTV + +
Sbjct: 903 IITIFFPFLALSGAVQTKMLTGFASQDKQALEKAGQITSEALSNIRTVAGIGVEGRFIKA 962
Query: 3048 YEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVV 2869
+E EL+ K AV K YG YL+ + VF VV
Sbjct: 963 FEVELQTSYKTAVRKANIYGLCFAFSQGIAFLANSAAYRYGGYLIAYEGLGF-SHVFRVV 1021
Query: 2868 MSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFE 2689
S++L A +G + A++SAA +Q +DR P I+ YS+AG++ N G++ F
Sbjct: 1022 SSVVLSATAVGRTFSYTPSYAKAKISAARFFQLLDRKPPINVYSEAGEKWDNFQGKIDFI 1081
Query: 2688 NVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDG 2509
+ F YPSR D ++LNGL++ V PG ++A VG SGCGKSTS+ LL R Y+P+ G V IDG
Sbjct: 1082 DCKFTYPSRPDIQVLNGLSVSVNPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGTVMIDG 1141
Query: 2508 TDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIE----VCKMANAHD 2341
D +++NI++LR+ +GIV QEP+LF+ +I +N+ G+ +T+E +E K A HD
Sbjct: 1142 HDSKKVNIQFLRSNIGIVSQEPVLFDCSIMDNIKYGD--NTKEISVERAIAAAKQAQLHD 1199
Query: 2340 FIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQS 2161
F+ +P+ Y+T +G G QLS G+KQR+AIAR ++RDPK+LLLDEATSALD +SE VQ+
Sbjct: 1200 FVMSLPEKYETNVGIQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQT 1259
Query: 2160 ALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLV 1996
AL+ A +GRT I+IAHRLSTI+ +D I +GV++E G HE+L+ G Y+ LV
Sbjct: 1260 ALDKAREGRTCIVIAHRLSTIQNSDIIAVVSQGVVIEKGTHEKLMAQKGAYYKLV 1314
Score = 274 bits (700), Expect = 1e-71
Identities = 192/622 (30%), Positives = 300/622 (47%), Gaps = 42/622 (6%)
Frame = -1
Query: 1755 DGQITAGYLDIFKNAKGNYLY-MFLGTVFALIRGLELPALALIFGWVFEGF--------- 1606
+G I G+ ++F+ + ++ M +G V AL+ G+ P + +IFG + + F
Sbjct: 40 EGDIRVGFFELFRFSSSKDIWLMLMGGVCALLHGMAQPGILIIFGIMTDIFIKYDIERQE 99
Query: 1605 -----------TFVPYGGRMMHRMAMAVIA---------------FASVGVGVWFSQLAS 1504
T V M + +A VG+ V
Sbjct: 100 LEIPGKACVNNTIVWINSSFHQNMTNGTVCGLVDIESEMIKFSGIYAGVGMTVLILGYFQ 159
Query: 1503 SVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARM 1324
L+ + R R FR ++ + +FD + G+L +R A D I + ++
Sbjct: 160 IRLWVITGARQIRRMRKIYFRRIMRMEIGWFD--CTSVGELNSRFADDIEKINDAIADQL 217
Query: 1323 LQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAF--VMIGLAYKISLMNVEQIQNDD 1150
W+ + +IGL+ +E
Sbjct: 218 AHFLQRMSTAMCGLLLGFYRGWKLTLVILAVSPLIGIGAAVIGLSIA-KFTELELKAYAK 276
Query: 1149 AGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFM 970
AG IA E++ +++T+ + Y+ + +R + KGM+ ++F
Sbjct: 277 AGSIADEVLSSIRTVAAFGGENKEVERYEKNLVFAQRWGIWKGMVMGFFTGYMWCLIFFC 336
Query: 969 MCFTYAVGIRIIYQGDKSSDDTFKGI-IAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNI 793
+ G ++ ++ + T I + ++L A+ + +++ F +AA +F
Sbjct: 337 YALAFWYGSTLVLDEEEYTPGTLVQIFLCVILAAMNIGHASSCLEIFSTGCSAATNIFQT 396
Query: 792 IYRKPRTGDLMEGDR---PEIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVG 622
I R+P D M GD I+G I F NV F YP RP I+ L G+T ALVG
Sbjct: 397 IDRQPVI-DCMSGDGYKLDRIKGEIEFHNVTFHYPSRPDVKILDNLSMVIKPGETTALVG 455
Query: 621 PSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIREN 442
SG+GKST + +++RFYD G + +DG DIR L++ LR Q+ +V QEP LF+ TI EN
Sbjct: 456 SSGAGKSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAEN 515
Query: 441 VCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVR 262
+ G +D +E I QA + ANA F+ LP DT VGE GGQ+SGGQKQR+AIARAL+R
Sbjct: 516 IRFGREDATMEDIVQAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQKQRVAIARALIR 575
Query: 261 DPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQ 82
+PKILLLD ATSALD+ESE VQEAL++ + G T I++AHRLS+++ +D+I+ + G
Sbjct: 576 NPKILLLDMATSALDNESEARVQEALNKIQHGHTIISVAHRLSTVRAADVIIGFEHGVAV 635
Query: 81 EAGNHTQLMHQKGRYYKLIKKQ 16
E G H +L+ +KG Y+ L+ Q
Sbjct: 636 ERGTHEELLERKGVYFMLVTLQ 657
>gi|13929072|ref|NP_113948.1| ATP-binding cassette, sub-family B
(MDR/TAP), member 11; sister of P-glycoprotein; bile salt
export pump [Rattus norvegicus]
gi|12585136|sp|O70127|AB11_RAT Bile salt export pump (ATP-binding
cassette, sub-family B, member 11) (Sister of
P-glycoprotein)
gi|11346285|pir||T42842 bile salt transport protein, ATP-dependent -
rat
gi|3075422|gb|AAC40084.1| bile salt export pump [Rattus norvegicus]
Length = 1321
Score = 704 bits (1816), Expect = 0.0
Identities = 438/1295 (33%), Positives = 667/1295 (50%), Gaps = 67/1295 (5%)
Frame = -1
Query: 3708 LFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQF--------- 3556
LFR+ D L+ +G +CA++ G++QP + ++ G +T+ + Y ++
Sbjct: 50 LFRFSSSKDIWLMLMGGVCALLHGMAQPGILIIFGIMTDIFIKYDIERQELEIPGKACVN 109
Query: 3555 -----------RNKANENVY--------------IFLGIGIFISITNFIQYMCFQHCCTR 3451
+N N V I+ G+G+ + I + Q + R
Sbjct: 110 NTIVWINSSFHQNMTNGTVCGLVDIESEMIKFSGIYAGVGMTVLILGYFQIRLWVITGAR 169
Query: 3450 VMAQMRHRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIA 3271
+ +MR + ++R GWFD G + ++ D +E+I + I D+L L+ + +
Sbjct: 170 QIRRMRKIYFRRIMRMEIGWFDCTSVGELNSRFADDIEKINDAIADQLAHFLQRMSTAMC 229
Query: 3270 AIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVR 3091
+++ + W+L ++L V+P I +++ + T EL KAGSIA+E L +R
Sbjct: 230 GLLLGFYRGWKLTLVILAVSPLIGIGAAVIGLSIAKFTELELKAYAKAGSIADEVLSSIR 289
Query: 3090 TVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLK 2911
TV AF G+ + V RYE L +++ +WK YG+ L+
Sbjct: 290 TVAAFGGENKEVERYEKNLVFAQRWGIWKGMVMGFFTGYMWCLIFFCYALAFWYGSTLVL 349
Query: 2910 VGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKA 2731
TPG + + + ++L A +G S + + +A +I+QTIDR P ID S
Sbjct: 350 DEEEYTPGTLVQIFLCVILAAMNIGHASSCLEIFSTGCSAATNIFQTIDRQPVIDCMSGD 409
Query: 2730 GKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLT 2551
G +L + G ++F NV F YPSR D KIL+ L++V++PG + ALVG SG GKST++ L+
Sbjct: 410 GYKLDRIKGEIEFHNVTFHYPSRPDVKILDNLSMVIKPGETTALVGSSGAGKSTALQLIQ 469
Query: 2550 RLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMI 2371
R Y+P G VT+DG D+R LNI WLR+ +GIV+QEP+LF+ TI N+ G +T E ++
Sbjct: 470 RFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAENIRFGREDATMEDIV 529
Query: 2370 EVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSAL 2191
+ K ANA++FI +P+ +DTL+G+GG Q+SGGQKQRVAIAR LIR+PK+LLLD ATSAL
Sbjct: 530 QAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSAL 589
Query: 2190 DAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGR 2011
D +SE+ VQ ALN G T I +AHRLST+R AD I+ FE GV VE G HEEL+ G
Sbjct: 590 DNESEARVQEALNKIQHGHTIISVAHRLSTVRAADVIIGFEHGVAVERGTHEELLERKGV 649
Query: 2010 YFDLVKAQQFKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFS 1831
YF LV Q + D T G +L +FS
Sbjct: 650 YFMLVTLQ----SQGDNAHKETSIMGKDAT--------------------EGGTLERTFS 685
Query: 1830 -GSKRSXXXXXXXXXXXXXXXXXXXEDGQITAGYLDIFKNAKGN---------------- 1702
GS R + A + +K++K N
Sbjct: 686 RGSYRDSLRASIRQRSKSQLSLLTHDPPLAVADHKSSYKDSKDNDVLVEEVEPAPVRRIL 745
Query: 1701 ------YLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGRM--MHRMAMAVIAF 1546
+ Y+ +G++ A I G P +L+F + F+ + + +H M + +
Sbjct: 746 KYNIPEWHYILVGSLSAAINGAVTPIYSLLFSQLLGTFSLLDKEQQRSEIHSMCLFFVIL 805
Query: 1545 ASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLA 1366
V + F+Q FA E L+ R R F+ +L QD +FD+ + PG L TRLA
Sbjct: 806 GCVSI---FTQFLQGYTFAKSGELLTKRLRKFGFKAMLGQDIGWFDDLRNNPGVLTTRLA 862
Query: 1365 SDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKI 1186
+DA ++ +++ + + W+ F+ + A +
Sbjct: 863 TDASQVQGATGSQVGMMVNSFTNIIAALLIAFFFSWK---LSLIITIFFPFLALSGAVQT 919
Query: 1185 SLMNVEQIQN----DDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGM 1018
++ Q+ + AG+I E + N++T+ + F ++ + ++ ++K
Sbjct: 920 KMLTGFASQDKQALEKAGQITSEALSNIRTVAGIGVEGRFIKAFEVELQTSYKTAVRKAN 979
Query: 1017 IEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFP 838
I + ++ +Q + Y G +I F+ + ++ L A AV + Y P
Sbjct: 980 IYGLCFAFSQGIAFLANSAAYRYGGYLIAYEGLGFSHVFRVVSSVALSATAVGRTFSYTP 1039
Query: 837 EFVKAKTAAGMLFNIIYRKPRTGDLMEGDR--PEIRGNILFENVKFSYPQRPLQPIMKGL 664
+ KAK +A F ++ RKP E +G I F + KF+YP RP ++ GL
Sbjct: 1040 SYAKAKISAARFFQLLDRKPPINVYSEAGEKWDNFQGKIDFIDCKFTYPSRPDIQVLNGL 1099
Query: 663 QWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALV 484
+ GQT+A VG SG GKST+I +LERFYD G + IDG D +K+++ LR+ + +V
Sbjct: 1100 SVSVNPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGTVMIDGHDSKKVNIQFLRSNIGIV 1159
Query: 483 GQEPRLFAGTIRENVCLG--LKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQL 310
QEP LF +I +N+ G K++ +E+ A + A + F+ +LP +T+VG +G QL
Sbjct: 1160 SQEPVLFDCSIMDNIKYGDNTKEISVERAIAAAKQAQLHDFVMSLPEKYETNVGIQGSQL 1219
Query: 309 SGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSS 130
S G+KQRIAIARA+VRDPKILLLDEATSALD+ESE+ VQ ALD+AREGRTCI IAHRLS+
Sbjct: 1220 SRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQTALDKAREGRTCIVIAHRLST 1279
Query: 129 IQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLI 25
IQNSD+I + +G V E G H +LM QKG YYKL+
Sbjct: 1280 IQNSDIIAVVSQGVVIEKGTHEKLMAQKGAYYKLV 1314
Score = 371 bits (953), Expect = e-101
Identities = 226/655 (34%), Positives = 359/655 (54%), Gaps = 6/655 (0%)
Frame = -1
Query: 3942 QRRPSQRSTVLAIPALAVNDPKSDPKIASDLPANYVDDDDDAPKMYTPSLLEKILNYALC 3763
QR SQ S + P LAV D KS K + D +D + P+ + +IL Y
Sbjct: 699 QRSKSQLSLLTHDPPLAVADHKSSYKDSKD--------NDVLVEEVEPAPVRRILKY--- 747
Query: 3762 RGDIANQQLEAQPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALL 3583
+IP ++ Y+L +G++ A I+G PI +L+ ++
Sbjct: 748 --------------NIP-------EWHYIL--VGSLSAAINGAVTPIYSLLFSQLLGTFS 784
Query: 3582 VYPPTSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQ 3403
+ +Q R++ + F+ +G T F+Q F + ++R ++L Q
Sbjct: 785 LLD--KEQQRSEIHSMCLFFVILGCVSIFTQFLQGYTFAKSGELLTKRLRKFGFKAMLGQ 842
Query: 3402 NAGWFD--KNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLAS 3229
+ GWFD +N+ G +TT+L +++ G ++G+++ F +IAA+++A+ + W+L+
Sbjct: 843 DIGWFDDLRNNPGVLTTRLATDASQVQGATGSQVGMMVNSFTNIIAALLIAFFFSWKLSL 902
Query: 3228 MMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGR 3049
++ P + ++ + +T ++ + KAG I E+L +RTV + +
Sbjct: 903 IITIFFPFLALSGAVQTKMLTGFASQDKQALEKAGQITSEALSNIRTVAGIGVEGRFIKA 962
Query: 3048 YEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVV 2869
+E EL+ K AV K YG YL+ + VF VV
Sbjct: 963 FEVELQTSYKTAVRKANIYGLCFAFSQGIAFLANSAAYRYGGYLIAYEGLGF-SHVFRVV 1021
Query: 2868 MSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFE 2689
S+ L A +G + A++SAA +Q +DR P I+ YS+AG++ N G++ F
Sbjct: 1022 SSVALSATAVGRTFSYTPSYAKAKISAARFFQLLDRKPPINVYSEAGEKWDNFQGKIDFI 1081
Query: 2688 NVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDG 2509
+ F YPSR D ++LNGL++ V PG ++A VG SGCGKSTS+ LL R Y+P+ G V IDG
Sbjct: 1082 DCKFTYPSRPDIQVLNGLSVSVNPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGTVMIDG 1141
Query: 2508 TDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIE----VCKMANAHD 2341
D +++NI++LR+ +GIV QEP+LF+ +I +N+ G+ +T+E +E K A HD
Sbjct: 1142 HDSKKVNIQFLRSNIGIVSQEPVLFDCSIMDNIKYGD--NTKEISVERAIAAAKQAQLHD 1199
Query: 2340 FIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQS 2161
F+ +P+ Y+T +G G QLS G+KQR+AIAR ++RDPK+LLLDEATSALD +SE VQ+
Sbjct: 1200 FVMSLPEKYETNVGIQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQT 1259
Query: 2160 ALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLV 1996
AL+ A +GRT I+IAHRLSTI+ +D I +GV++E G HE+L+ G Y+ LV
Sbjct: 1260 ALDKAREGRTCIVIAHRLSTIQNSDIIAVVSQGVVIEKGTHEKLMAQKGAYYKLV 1314
Score = 274 bits (700), Expect = 1e-71
Identities = 192/622 (30%), Positives = 300/622 (47%), Gaps = 42/622 (6%)
Frame = -1
Query: 1755 DGQITAGYLDIFKNAKGNYLY-MFLGTVFALIRGLELPALALIFGWVFEGF--------- 1606
+G I G+ ++F+ + ++ M +G V AL+ G+ P + +IFG + + F
Sbjct: 40 EGDIRVGFFELFRFSSSKDIWLMLMGGVCALLHGMAQPGILIIFGIMTDIFIKYDIERQE 99
Query: 1605 -----------TFVPYGGRMMHRMAMAVIA---------------FASVGVGVWFSQLAS 1504
T V M + +A VG+ V
Sbjct: 100 LEIPGKACVNNTIVWINSSFHQNMTNGTVCGLVDIESEMIKFSGIYAGVGMTVLILGYFQ 159
Query: 1503 SVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARM 1324
L+ + R R FR ++ + +FD + G+L +R A D I + ++
Sbjct: 160 IRLWVITGARQIRRMRKIYFRRIMRMEIGWFD--CTSVGELNSRFADDIEKINDAIADQL 217
Query: 1323 LQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAF--VMIGLAYKISLMNVEQIQNDD 1150
W+ + +IGL+ +E
Sbjct: 218 AHFLQRMSTAMCGLLLGFYRGWKLTLVILAVSPLIGIGAAVIGLSIA-KFTELELKAYAK 276
Query: 1149 AGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFM 970
AG IA E++ +++T+ + Y+ + +R + KGM+ ++F
Sbjct: 277 AGSIADEVLSSIRTVAAFGGENKEVERYEKNLVFAQRWGIWKGMVMGFFTGYMWCLIFFC 336
Query: 969 MCFTYAVGIRIIYQGDKSSDDTFKGI-IAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNI 793
+ G ++ ++ + T I + ++L A+ + +++ F +AA +F
Sbjct: 337 YALAFWYGSTLVLDEEEYTPGTLVQIFLCVILAAMNIGHASSCLEIFSTGCSAATNIFQT 396
Query: 792 IYRKPRTGDLMEGDR---PEIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVG 622
I R+P D M GD I+G I F NV F YP RP I+ L G+T ALVG
Sbjct: 397 IDRQPVI-DCMSGDGYKLDRIKGEIEFHNVTFHYPSRPDVKILDNLSMVIKPGETTALVG 455
Query: 621 PSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIREN 442
SG+GKST + +++RFYD G + +DG DIR L++ LR Q+ +V QEP LF+ TI EN
Sbjct: 456 SSGAGKSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAEN 515
Query: 441 VCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVR 262
+ G +D +E I QA + ANA F+ LP DT VGE GGQ+SGGQKQR+AIARAL+R
Sbjct: 516 IRFGREDATMEDIVQAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQKQRVAIARALIR 575
Query: 261 DPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQ 82
+PKILLLD ATSALD+ESE VQEAL++ + G T I++AHRLS+++ +D+I+ + G
Sbjct: 576 NPKILLLDMATSALDNESEARVQEALNKIQHGHTIISVAHRLSTVRAADVIIGFEHGVAV 635
Query: 81 EAGNHTQLMHQKGRYYKLIKKQ 16
E G H +L+ +KG Y+ L+ Q
Sbjct: 636 ERGTHEELLERKGVYFMLVTLQ 657
>gi|12585141|sp|Q9N0V3|AB11_RABIT Bile salt export pump (ATP-binding
cassette, sub-family B, member 11) (Sister of
P-glycoprotein)
gi|7644354|gb|AAF65552.1| liver bile salt export pump [Oryctolagus
cuniculus]
Length = 1321
Score = 698 bits (1802), Expect = 0.0
Identities = 432/1286 (33%), Positives = 668/1286 (51%), Gaps = 58/1286 (4%)
Frame = -1
Query: 3708 LFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFR-------- 3553
LFR+ D L+ +G++CA I G++QP + L+ G +T+ + Y ++ +
Sbjct: 50 LFRFSSWTDIWLMCMGSLCACIHGIAQPGVLLIFGTMTDVFIDYDTELQELKIPGKACVN 109
Query: 3552 -------NKANENVY-------------------IFLGIGIFISITNFIQYMCFQHCCTR 3451
+ N+NV + GIGI + T +IQ +
Sbjct: 110 NTIVWINSSLNQNVTNGTRCGLLDIESEMIRFAGYYAGIGIAVLTTGYIQICFWGIAAAH 169
Query: 3450 VMAQMRHRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIA 3271
+ +MR + ++R GW D N G + T + +I + D+L + ++G I
Sbjct: 170 QIQKMRKSYFRKIMRMGIGWVDCNSVGKLNTPFSVDFNKINDSSADQLAIFIQGMTSPIF 229
Query: 3270 AIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVR 3091
+V + W+L +++ V+P + +++ ++ T EL KAGS+A+E + +R
Sbjct: 230 GFLVGFSQWWKLTLVIISVSPLIGLGAAIIGLSVSKFTDYELKAYAKAGSVADEVISSMR 289
Query: 3090 TVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLK 2911
TV AF G+++ V RYE L +++ + K YG+ L+
Sbjct: 290 TVAAFGGEKKEVERYEKNLVFAQRWGIRKGIVMGFFTGYMWCLIFFCYALAFWYGSKLVL 349
Query: 2910 VGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKA 2731
+PG + + +S+++GA LG SP + R +A+SI++TIDR P ID S+
Sbjct: 350 EEGEYSPGALVQIFLSVIIGALNLGNASPCLEAFAAGRAAASSIFETIDRKPIIDCMSED 409
Query: 2730 GKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLT 2551
G +L+ + G ++F NV F YPSR + KILN L++V++PG ALVG SG GKST++ L+
Sbjct: 410 GYKLERIKGEIEFHNVTFHYPSRPEVKILNNLSMVIKPGEMTALVGPSGAGKSTALQLIH 469
Query: 2550 RLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMI 2371
R Y P G VT++ D+R +I+WLRN +GIV+QEP+LF TI + G +T E +I
Sbjct: 470 RFYGPTEGMVTVESHDIRSSHIQWLRNQIGIVEQEPVLFFHTIAEKIRYGREDATMEDLI 529
Query: 2370 EVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSAL 2191
+ K ANA++FI +P+ +DTL+G+GG Q+SGGQKQRVAIAR LIR+PK+LLLD ATSAL
Sbjct: 530 QAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSAL 589
Query: 2190 DAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGR 2011
D +SE++VQ AL+ G T + +AHR +TIR AD I+ E G VE G EEL+ G
Sbjct: 590 DNESEAMVQEALSKTQHGHTIVSVAHRPATIRTADVIIGCEHGAAVERGTEEELLERKGV 649
Query: 2010 YFDLVKAQQFKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFS 1831
YF LV Q + D + F RGN DS
Sbjct: 650 YFALVTLQSQRNQGDQEENEKDATED----------------DIPEKTFSRGN-YQDSLR 692
Query: 1830 GSKRSXXXXXXXXXX---------XXXXXXXXXEDGQI-------TAGYLDIFKNAKGNY 1699
S R +D + A I K +
Sbjct: 693 ASLRQRSKSQLSYLAHEPPMAVEDHKSTHEEDRKDKDLPAQEDIEPASVRRIMKLNAPEW 752
Query: 1698 LYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWF 1519
YM LG++ A + G P A +F + F+ +P ++ + F ++G +F
Sbjct: 753 PYMLLGSMGAAVNGAVTPLYAFLFSQILGTFS-LPDKEEQRSQINGICLLFVTLGCVSFF 811
Query: 1518 SQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAV 1339
+Q FA E L+ R R FR +L QD +FD+ ++PG L TRLA+DA ++
Sbjct: 812 TQFLQGYTFAKSGELLTKRLRKFGFRAMLGQDIGWFDDLRNSPGALTTRLATDASQVQGA 871
Query: 1338 VDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLM----NV 1171
+++ + ++ W+ F+ + A + ++ +
Sbjct: 872 TGSQIGMMVNSFTNVTVAMIIAFLFSWK---LTLGIVCFFPFLALSGALQTKMLTGFASR 928
Query: 1170 EQIQNDDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLT 991
++ + AG+I E + N++T+ + + F + ++ ++ + +KK + + + +
Sbjct: 929 DKQALEKAGQITSEALSNIRTVAGIGKERKFIETFEAELEKPYKMAIKKANVYGLCFGFS 988
Query: 990 QSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAA 811
Q + +Y G +I F+ I A++L A A+ ++ Y P + KAK +A
Sbjct: 989 QCITFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRASSYTPSYAKAKISA 1048
Query: 810 GMLFNIIYRKPRTGDLMEGDR--PEIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQT 637
F ++ R+P +G I F + KF+YP RP ++ GL + QT
Sbjct: 1049 ARFFQLLDRQPPINVYSSAGEKWDNFQGKIDFVDCKFTYPSRPDIQVLNGLSVSMSPRQT 1108
Query: 636 VALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAG 457
+A VG SG GKST+I +LERFYD G + IDG D RK+++ LR+ + +V QEP LFA
Sbjct: 1109 LAFVGSSGCGKSTSIQLLERFYDPDHGKVMIDGHDSRKVNIQFLRSNIGIVSQEPVLFAC 1168
Query: 456 TIRENVCLG--LKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIA 283
+I++N+ G +++P+E+I A + A + F+ +LP +T+VG +G QLS G+KQRIA
Sbjct: 1169 SIKDNIKYGDNTQEIPMERIIAAAKKAQVHDFVMSLPEKYETNVGSQGSQLSRGEKQRIA 1228
Query: 282 IARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVY 103
IARA+VRDPKILLLDEATSALD+ESE+ VQ ALD+AREGRTCI IAHRLS+IQNSD+I
Sbjct: 1229 IARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNSDIIAV 1288
Query: 102 IDKGKVQEAGNHTQLMHQKGRYYKLI 25
+ +G V E G H +LM QKG YYKL+
Sbjct: 1289 MSQGMVIEKGTHEELMVQKGAYYKLV 1314
Score = 370 bits (949), Expect = e-100
Identities = 222/657 (33%), Positives = 353/657 (52%), Gaps = 8/657 (1%)
Frame = -1
Query: 3942 QRRPSQRSTVLAIPALAVNDPKS---DPKIASDLPANYVDDDDDAPKMYTPSLLEKILNY 3772
QR SQ S + P +AV D KS + + DLPA
Sbjct: 697 QRSKSQLSYLAHEPPMAVEDHKSTHEEDRKDKDLPA------------------------ 732
Query: 3771 ALCRGDIANQQLEAQPVSIPGLFRYGK-KFDYLLLFIGTICAIISGVSQPILALVSGRVT 3595
Q + +P S+ + + ++ Y+LL G++ A ++G P+ A + ++
Sbjct: 733 ----------QEDIEPASVRRIMKLNAPEWPYMLL--GSMGAAVNGAVTPLYAFLFSQIL 780
Query: 3594 NALLVYPPTSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYS 3415
+ P ++ R++ N +F+ +G T F+Q F + ++R +
Sbjct: 781 GTFSL--PDKEEQRSQINGICLLFVTLGCVSFFTQFLQGYTFAKSGELLTKRLRKFGFRA 838
Query: 3414 VLRQNAGWFD--KNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEW 3241
+L Q+ GWFD +N G +TT+L +++ G ++G+++ F + A+++A+++ W
Sbjct: 839 MLGQDIGWFDDLRNSPGALTTRLATDASQVQGATGSQIGMMVNSFTNVTVAMIIAFLFSW 898
Query: 3240 RLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEE 3061
+L ++ P + +L + +T ++ + KAG I E+L +RTV + +
Sbjct: 899 KLTLGIVCFFPFLALSGALQTKMLTGFASRDKQALEKAGQITSEALSNIRTVAGIGKERK 958
Query: 3060 MVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDV 2881
+ +EAELEK K A+ K YG YL+ + V
Sbjct: 959 FIETFEAELEKPYKMAIKKANVYGLCFGFSQCITFIANSASYRYGGYLISNEGLHF-SYV 1017
Query: 2880 FIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGR 2701
F V+ +++L A LG S + A++SAA +Q +DR P I+ YS AG++ N G+
Sbjct: 1018 FRVISAVVLSATALGRASSYTPSYAKAKISAARFFQLLDRQPPINVYSSAGEKWDNFQGK 1077
Query: 2700 VKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNV 2521
+ F + F YPSR D ++LNGL++ + P ++A VG SGCGKSTS+ LL R Y+P+ G V
Sbjct: 1078 IDFVDCKFTYPSRPDIQVLNGLSVSMSPRQTLAFVGSSGCGKSTSIQLLERFYDPDHGKV 1137
Query: 2520 TIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGS--TRETMIEVCKMANA 2347
IDG D R++NI++LR+ +GIV QEP+LF +I +N+ G+ E +I K A
Sbjct: 1138 MIDGHDSRKVNIQFLRSNIGIVSQEPVLFACSIKDNIKYGDNTQEIPMERIIAAAKKAQV 1197
Query: 2346 HDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIV 2167
HDF+ +P+ Y+T +G G QLS G+KQR+AIAR ++RDPK+LLLDEATSALD +SE V
Sbjct: 1198 HDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTV 1257
Query: 2166 QSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLV 1996
Q AL+ A +GRT I+IAHRLSTI+ +D I +G+++E G HEEL+ G Y+ LV
Sbjct: 1258 QVALDKAREGRTCIVIAHRLSTIQNSDIIAVMSQGMVIEKGTHEELMVQKGAYYKLV 1314
Score = 253 bits (647), Expect = 2e-65
Identities = 178/624 (28%), Positives = 297/624 (47%), Gaps = 47/624 (7%)
Frame = -1
Query: 1746 ITAGYLDIFKNAKGNYLY-MFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGRMMH- 1573
+ G+ +F+ + ++ M +G++ A I G+ P + LIFG + + F+ Y +
Sbjct: 43 VRIGFFQLFRFSSWTDIWLMCMGSLCACIHGIAQPGVLLIFGTMTD--VFIDYDTELQEL 100
Query: 1572 ------------------------------------RMAMAVIAFASVGVGVWFSQLASS 1501
M +A +G+ V +
Sbjct: 101 KIPGKACVNNTIVWINSSLNQNVTNGTRCGLLDIESEMIRFAGYYAGIGIAVLTTGYIQI 160
Query: 1500 VLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARML 1321
+ + + + + R FR ++ + D ++ GKL T + D I ++
Sbjct: 161 CFWGIAAAHQIQKMRKSYFRKIMRMGIGWVD--CNSVGKLNTPFSVDFNKINDSSADQLA 218
Query: 1320 QVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQNDD--- 1150
W+ +IGL I ++V + + +
Sbjct: 219 IFIQGMTSPIFGFLVGFSQWWKLTLVIISVSP-----LIGLGAAIIGLSVSKFTDYELKA 273
Query: 1149 ---AGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFM 979
AG +A E+I +++T+ + + Y+ + +R ++KG++ +
Sbjct: 274 YAKAGSVADEVISSMRTVAAFGGEKKEVERYEKNLVFAQRWGIRKGIVMGFFTGYMWCLI 333
Query: 978 YFMMCFTYAVGIRIIYQ-GDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGML 802
+F + G +++ + G+ S + +++++GA+ + N++ F + AA +
Sbjct: 334 FFCYALAFWYGSKLVLEEGEYSPGALVQIFLSVIIGALNLGNASPCLEAFAAGRAAASSI 393
Query: 801 FNIIYRKPRTGDLME-GDRPE-IRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVAL 628
F I RKP + E G + E I+G I F NV F YP RP I+ L G+ AL
Sbjct: 394 FETIDRKPIIDCMSEDGYKLERIKGEIEFHNVTFHYPSRPEVKILNNLSMVIKPGEMTAL 453
Query: 627 VGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIR 448
VGPSG+GKST + ++ RFY T G + ++ DIR + LR Q+ +V QEP LF TI
Sbjct: 454 VGPSGAGKSTALQLIHRFYGPTEGMVTVESHDIRSSHIQWLRNQIGIVEQEPVLFFHTIA 513
Query: 447 ENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARAL 268
E + G +D +E + QA + ANA F+ +LP DT VGE GGQ+SGGQKQR+AIARAL
Sbjct: 514 EKIRYGREDATMEDLIQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARAL 573
Query: 267 VRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGK 88
+R+PKILLLD ATSALD+ESE VQEAL + + G T +++AHR ++I+ +D+I+ + G
Sbjct: 574 IRNPKILLLDMATSALDNESEAMVQEALSKTQHGHTIVSVAHRPATIRTADVIIGCEHGA 633
Query: 87 VQEAGNHTQLMHQKGRYYKLIKKQ 16
E G +L+ +KG Y+ L+ Q
Sbjct: 634 AVERGTEEELLERKGVYFALVTLQ 657
>gi|18496816|gb|AAL74249.1| ABC transporter AbcB2 [Dictyostelium
discoideum]
Length = 1407
Score = 698 bits (1801), Expect = 0.0
Identities = 439/1346 (32%), Positives = 690/1346 (50%), Gaps = 68/1346 (5%)
Frame = -1
Query: 3849 PANYVDDDDDAPKMYTPSLLEKILNYALCRGDIANQQLEAQPVSIPGLFRYGKKFDYLLL 3670
P + D D+ K + + +K+ G++ Q V LFR+ K FD LL+
Sbjct: 87 PIDITSDGGDSVKTLSTTQSKKLDEGEKKEGEVGPQ------VPFFSLFRFAKPFDILLM 140
Query: 3669 FIGTICAIISGVSQPILALVSGRVTNAL----LVYPPTSKQFRNKANENVYIFLGIGIFI 3502
IGTI A+ +GVS P +++V GR+ N+ L P +N +I++G G+F+
Sbjct: 141 IIGTIGALANGVSMPAISIVFGRLMNSFSPENLADPNFDLVETVTSNAMYFIYIGCGVFV 200
Query: 3501 SITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREG 3322
++++ + R + R ++ ++L+Q GW+D S ++T+++ +E
Sbjct: 201 C--SYVEVAFWMLAGERQAVRCRKAYLKAILKQEIGWYDVTKSSELSTRISSDTLLFQEA 258
Query: 3321 IGDKLGVLLRGFAMLIAAIVVAYI----------YEWRLASMMLGVAPTCCICMSLLARQ 3172
IG+K+G L + I +V ++ + W+L ++ + P + + +
Sbjct: 259 IGEKIGNFLHHTSTFICGFIVGFVNGKNYNYYLFFCWQLTLVIFALTPLIAAAGAFMTKM 318
Query: 3171 MTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXX 2992
M T K KAG +AEE + +RTV F+G+ V RY L++ K
Sbjct: 319 MADLTKKGQDAYAKAGGVAEEKIGSIRTVSTFSGEPFEVKRYTERLKEALDIGTKKGIMN 378
Query: 2991 XXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTP--------GDVFIVVMSMLLGAYFLG 2836
YG L+ V P GDV V S+++GA LG
Sbjct: 379 GIGIGLVFLVLFGTYSLSFWYGGKLI-VDRKWNPVPDRPWQGGDVLTVFFSVIMGAMALG 437
Query: 2835 LISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVV-GRVKFENVHFRYPSRK 2659
SP++ N R +A IY+ +DR KIDP+S G+ ++ V G +++ N+ F YPSR
Sbjct: 438 QASPNVASFANGRGAAFKIYEVVDRNSKIDPFSTEGRSIEETVQGNIEYRNIGFSYPSRP 497
Query: 2658 DAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEW 2479
D KI N NL ++ GT+VALVG SG GKS+ +GLL R Y+P+ G V +DGT+++E+NI
Sbjct: 498 DVKIFNNFNLTIKKGTTVALVGDSGGGKSSVIGLLERFYDPDEGEVYLDGTNIKEINIHS 557
Query: 2478 LRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYDTLIG 2299
LR +G+V QEP+LF ++I N+ GN +T + +IE CK ANAHDFI +P+GYDT +G
Sbjct: 558 LRRNIGLVSQEPVLFANSIAENIRYGNENATMDQIIEACKTANAHDFISALPEGYDTQVG 617
Query: 2298 DGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMI 2119
+ GVQ+SGGQKQR+AIAR +I+DPK+LLLDEATSALD+Q+E +VQ ++ GRTTI+I
Sbjct: 618 EKGVQMSGGQKQRIAIARAMIKDPKILLLDEATSALDSQNELLVQQSIEKLMIGRTTIVI 677
Query: 2118 AHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKADPXXXXXXXXXE 1939
AHRLSTI++AD+I + G IVE G H EL L G Y LV QQ D +
Sbjct: 678 AHRLSTIQDADQIAVVKGGAIVEIGTHPELYALNGVYTQLVNRQQKGGDDGDKKKKKKSK 737
Query: 1938 IDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXXXXXXXXXXXXXXX 1759
D ++ +SL S G
Sbjct: 738 ESSKDESNNNIGPSSISIDKSIQSI-GADSLETSTIG------LVNDNDNKKKKKKEKKP 790
Query: 1758 EDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYG--G 1585
++ + G I K ++G++ + +G V A + G +P ++IF + F
Sbjct: 791 QEKSVPIG--RILKLSRGDWPHFLIGLVGATLNGAIMPVFSIIFSEILGIFQEQDTDELT 848
Query: 1584 RMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDN 1405
R MA+ I A V F Q+ F + E L+ R SF +++ QD +FD
Sbjct: 849 RRSRNMALWFILLAVVAALANFIQI---YCFTFIGEKLTFNLRRLSFESIMRQDIGWFDL 905
Query: 1404 PAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXX 1225
++ G+L LA++A ++ + R+ + + W+
Sbjct: 906 TENSTGRLTANLATEATLVQGMTSQRLGLLIQNIVTIVAGLVIAFVSGWK-----LTLVV 960
Query: 1224 XLAFVMIGLAYKISLMNVEQIQND------DAGRIAIEIIENVKTIQLLTRCELFFDHYQ 1063
+IG A K+ + + + G++A E I ++T+ T + ++
Sbjct: 961 LACVPVIGFAGKVEMDFFQGFSQKGKEAYAECGQVASEAIGGIRTVSSFTCENKILEKFR 1020
Query: 1062 TSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGD----KSSDDTF-- 901
++ + +K + +++ +Q ++F+ TY G +++ G+ +S+ +T+
Sbjct: 1021 QCLQKPIQMSFRKSNVSGLSFGFSQCTLFFIYTLTYWYGGKLVDSGEWPAKESTLETYCY 1080
Query: 900 -----------------------------KGIIAMMLGAVAVMNSAQYFPEFVKAKTAAG 808
+ A+++ A+ V S + P+ KAK AA
Sbjct: 1081 NGEYANIGYTDEATCIKSFTTTEGFSMMMRVFFAIIMSAMGVGQSMAFMPDLGKAKLAAV 1140
Query: 807 MLFNIIYRKPRTGDLMEGDR--PEIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTV 634
+F++I R + PE +G+I F+++KFSYP RP + + +G G+ V
Sbjct: 1141 AIFSLIDRVSEIDPFENKGQTLPEFKGDIEFKDIKFSYPSRPNKAVFQGFNLVIPHGKKV 1200
Query: 633 ALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGT 454
ALVG SG GKS+ I +LERFY+ + G++ IDG +I+ L+L LR M LVGQEP LF+GT
Sbjct: 1201 ALVGNSGGGKSSVISLLERFYNPSQGSITIDGVNIKDLNLNWLRGNMGLVGQEPFLFSGT 1260
Query: 453 IRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIAR 274
I EN+ G D ++++ +A + ANA+ F+ +LP T +G+K QLSGGQKQR+AIAR
Sbjct: 1261 IFENIIYGKPDATMDEVVEAAKAANAHTFIESLPDAYHTQLGDKFTQLSGGQKQRVAIAR 1320
Query: 273 ALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDK 94
A++R+PK+LLLDEATSALD+ SE+ VQ ALD +GRT I IAHRLS++ ++DLIV + +
Sbjct: 1321 AIIRNPKVLLLDEATSALDTVSEKVVQVALDNVSKGRTSIVIAHRLSTVIDADLIVVVKE 1380
Query: 93 GKVQEAGNHTQLMHQKGRYYKLIKKQ 16
GKV E G H L+ + G Y +L+ +Q
Sbjct: 1381 GKVVELGTHETLLAENGFYAELVSRQ 1406
>gi|40644167|emb|CAC86593.1| sister of P-glycoprotein [Platichthys
flesus]
gi|40644169|emb|CAC86594.1| sister of P-glycoprotein [Platichthys
flesus]
Length = 1356
Score = 696 bits (1796), Expect = 0.0
Identities = 434/1309 (33%), Positives = 670/1309 (51%), Gaps = 68/1309 (5%)
Frame = -1
Query: 3747 NQQLEAQPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPT 3568
N + A V LFR+ + +++ IG++CA++ G +QP++ LV G +T+ + Y
Sbjct: 47 NAEQPAIRVGFFQLFRFSTCREVVMMVIGSVCAVLHGSAQPLMLLVFGLLTDTFIEYDIE 106
Query: 3567 SKQFRNKANENV------------------------------------------------ 3532
+ R+ E V
Sbjct: 107 LNELRDVRKECVNNTIQWKSDYTAALNQSDWSLNSTWEVLVPLKNLTCGVLDIEYEMTKF 166
Query: 3531 -YIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFDKNHSGTITTK 3355
++GI + + ++Q + R + +R + V+R GWFD G + T+
Sbjct: 167 ALYYVGIAFAVFLLGYLQISLWVQAAARQVQIVRKMYFSKVMRMEIGWFDCTSVGELNTR 226
Query: 3354 LNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLAR 3175
++D + +I + I D++ + L+ F + + ++ W+L +++ +P I +A
Sbjct: 227 MSDDINKINDAIADQVAIFLQRFTTFVCGFCIGFVKGWKLTLVIVAASPLIGIGAGFMAL 286
Query: 3174 QMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXX 2995
+ T +EL KAG++A+E L +RTV AF G+ + V RY+ L +++ + K
Sbjct: 287 FVAKLTGRELQAYAKAGAVADEVLSSIRTVSAFGGELKEVQRYDRNLISAQRWGIRKGMI 346
Query: 2994 XXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLISPHMM 2815
YG+ L+ TPG + V +L+ A LG SP +
Sbjct: 347 MGFFTGYMWLIIFLCYALAFWYGSGLVLDTAEYTPGTLLQVFFGVLIAAMNLGQASPCLE 406
Query: 2814 VLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKILNGL 2635
R +A I++TIDR P+ID S+AG +L V G ++F NV F YPSR + K L+ L
Sbjct: 407 AFAAGRGAATIIFETIDREPEIDCLSEAGYKLDRVKGDIEFHNVTFHYPSRPEVKTLDQL 466
Query: 2634 NLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIV 2455
++ V+ G + A VG SG GKST++ L R Y+P+ G VT+DG D+R LNI+WLR+ +GIV
Sbjct: 467 SVAVKSGETTAFVGPSGAGKSTAIQLFQRFYDPKEGMVTLDGHDIRGLNIQWLRSLIGIV 526
Query: 2454 QQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSG 2275
+QEP+LF TI N+ G PG + E ++ K ANA+ FI+ +P+ ++T++G+GG Q+SG
Sbjct: 527 EQEPVLFATTIAENICYGRPGVSMEDIVAAAKEANAYHFIQDLPQKFNTMVGEGGGQMSG 586
Query: 2274 GQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIR 2095
GQKQR+AIAR L+R+P++LLLD ATSALD +SE+IVQ AL+ GRTTI IAHRLSTI+
Sbjct: 587 GQKQRIAIARALVRNPRILLLDMATSALDNESEAIVQEALDKVRLGRTTISIAHRLSTIK 646
Query: 2094 EADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKADPXXXXXXXXXEIDLDDTXX 1915
AD IV FE G VE G H EL+ G YF ++ Q + D ++
Sbjct: 647 NADVIVGFEHGRAVEKGKHGELLERKGVYF-MLVTLQSQGDKALNEKARQLAEKEEEPVK 705
Query: 1914 XXXXXXXXXXXXXSEAFRRGN--SLNDSFSGSKRSXXXXXXXXXXXXXXXXXXXED---- 1753
+ R+ + L++ S S D
Sbjct: 706 QNLSRAGSYRASLRSSIRQRSRSQLSNLIPDSSASMVGELGPRTYTFSQPDTSKADIPEE 765
Query: 1752 --GQIT--AGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFV-PYG 1588
++ A I K + YM G++ A I G P +L+F + F+ P
Sbjct: 766 EEEEVVEPAPVARILKYNIPEWPYMLFGSIGAAINGGVNPVYSLLFSQILATFSVTDPVA 825
Query: 1587 GRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFD 1408
R + + F VGV F+Q+ F+ E L+ R R F +L Q+ +FD
Sbjct: 826 QRK--EIDSICMFFVMVGVVSSFTQMLQGYAFSKSGELLTRRLRRLGFHAMLGQEIGWFD 883
Query: 1407 NPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXX 1228
+ ++PG L TRLA+DA ++ +++ + + W+
Sbjct: 884 DHRNSPGALTTRLATDASQVQGATGSQIGMIVNSLTNIGVAVLMSFYFSWKLTMLILCFL 943
Query: 1227 XXLAFVMIGLAYKISLMNVEQIQNDDA----GRIAIEIIENVKTIQLLTRCELFFDHYQT 1060
F+ + ++ ++ Q+ +A GRI+ E + N++TI L + + F D Y+
Sbjct: 944 ---PFIALSGGFQAKMLTGFAKQDKEAMEAAGRISGEALNNIRTIAGLGKEQSFVDMYEA 1000
Query: 1059 SSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMM 880
++ LKK + Y Q ++ +Y G ++ Q F+ I A++
Sbjct: 1001 QLDGPFQAALKKAHVYGACYGFAQCVVFLTNSASYRFGGYLVRQEGLHFSLVFRVISAIV 1060
Query: 879 LGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLME-GDR-PEIRGNILFENVKF 706
A+ ++ Y P++ KAK +A F ++ R P+ + GD+ +GN+ F + KF
Sbjct: 1061 TSGTALGKASSYTPDYAKAKISAARFFKLLDRVPQISVYSDKGDKWDNFQGNLEFIDCKF 1120
Query: 705 SYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIR 526
+YP RP ++ GL + GQT+A VG SG GKST++ +LERFYD G + IDG D
Sbjct: 1121 TYPTRPDIQVLNGLNVSVRPGQTLAFVGSSGCGKSTSVQLLERFYDPDHGRVLIDGHDST 1180
Query: 525 KLSLFHLRTQMALVGQEPRLFAGTIRENVCLG--LKDVPLEKINQALELANANRFLANLP 352
+++ LR+++ +V QEP LF +I +N+ G +++ L + A + A + F+ LP
Sbjct: 1181 GVNVPFLRSKIGIVSQEPILFDCSIADNIKYGDNSREISLNDVMSAAKKAQLHNFVMALP 1240
Query: 351 AGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAR 172
DT+VG +G QLS GQKQRIAIARA++RDPKILLLDEATSALD+ESE+ VQEALD+AR
Sbjct: 1241 EKYDTNVGAQGSQLSRGQKQRIAIARAIIRDPKILLLDEATSALDTESEKIVQEALDKAR 1300
Query: 171 EGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLI 25
EGRTCI IAHRLS+IQNSD+I + +G V E G H QLM KG YYKL+
Sbjct: 1301 EGRTCIVIAHRLSTIQNSDIIAVMSRGYVIEKGTHNQLMLLKGAYYKLV 1349
Score = 353 bits (907), Expect = 1e-95
Identities = 205/598 (34%), Positives = 334/598 (55%), Gaps = 9/598 (1%)
Frame = -1
Query: 3762 RGDIANQQLE--AQPVSIPGLFRYG-KKFDYLLLFIGTICAIISGVSQPILALVSGRVTN 3592
+ DI ++ E +P + + +Y ++ Y+L G+I A I+G P+ +L+ ++
Sbjct: 759 KADIPEEEEEEVVEPAPVARILKYNIPEWPYMLF--GSIGAAINGGVNPVYSLLFSQILA 816
Query: 3591 ALLVYPPTSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSV 3412
V P ++ R + + F+ +G+ S T +Q F + ++R +++
Sbjct: 817 TFSVTDPVAQ--RKEIDSICMFFVMVGVVSSFTQMLQGYAFSKSGELLTRRLRRLGFHAM 874
Query: 3411 LRQNAGWFD--KNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWR 3238
L Q GWFD +N G +TT+L +++ G ++G+++ + A+++++ + W+
Sbjct: 875 LGQEIGWFDDHRNSPGALTTRLATDASQVQGATGSQIGMIVNSLTNIGVAVLMSFYFSWK 934
Query: 3237 LASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEM 3058
L ++L P + A+ +T ++ + AG I+ E+L +RT+ ++
Sbjct: 935 LTMLILCFLPFIALSGGFQAKMLTGFAKQDKEAMEAAGRISGEALNNIRTIAGLGKEQSF 994
Query: 3057 VGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVF 2878
V YEA+L+ + A+ K +G YL++ + VF
Sbjct: 995 VDMYEAQLDGPFQAALKKAHVYGACYGFAQCVVFLTNSASYRFGGYLVRQEGLHF-SLVF 1053
Query: 2877 IVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRV 2698
V+ +++ LG S + A++SAA ++ +DRVP+I YS G + N G +
Sbjct: 1054 RVISAIVTSGTALGKASSYTPDYAKAKISAARFFKLLDRVPQISVYSDKGDKWDNFQGNL 1113
Query: 2697 KFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVT 2518
+F + F YP+R D ++LNGLN+ V PG ++A VG SGCGKSTSV LL R Y+P+ G V
Sbjct: 1114 EFIDCKFTYPTRPDIQVLNGLNVSVRPGQTLAFVGSSGCGKSTSVQLLERFYDPDHGRVL 1173
Query: 2517 IDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRE----TMIEVCKMAN 2350
IDG D +N+ +LR+ +GIV QEPILF+ +I +N+ G+ ++RE ++ K A
Sbjct: 1174 IDGHDSTGVNVPFLRSKIGIVSQEPILFDCSIADNIKYGD--NSREISLNDVMSAAKKAQ 1231
Query: 2349 AHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESI 2170
H+F+ +P+ YDT +G G QLS GQKQR+AIAR +IRDPK+LLLDEATSALD +SE I
Sbjct: 1232 LHNFVMALPEKYDTNVGAQGSQLSRGQKQRIAIARAIIRDPKILLLDEATSALDTESEKI 1291
Query: 2169 VQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLV 1996
VQ AL+ A +GRT I+IAHRLSTI+ +D I +G ++E G H +L+ L G Y+ LV
Sbjct: 1292 VQEALDKAREGRTCIVIAHRLSTIQNSDIIAVMSRGYVIEKGTHNQLMLLKGAYYKLV 1349
Score = 268 bits (684), Expect = 1e-69
Identities = 162/386 (41%), Positives = 227/386 (57%), Gaps = 8/386 (2%)
Frame = -1
Query: 1149 AGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAI--NYSLTQSFMY 976
AG +A E++ +++T+ Y + +R ++KGMI Y F+
Sbjct: 302 AGAVADEVLSSIRTVSAFGGELKEVQRYDRNLISAQRWGIRKGMIMGFFTGYMWLIIFLC 361
Query: 975 FMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGA-VAVMNSAQYFP---EFVKAKTAAG 808
+ + F Y G+ + +++ T ++ + G +A MN Q P F + AA
Sbjct: 362 YALAFWYGSGLVL-----DTAEYTPGTLLQVFFGVLIAAMNLGQASPCLEAFAAGRGAAT 416
Query: 807 MLFNIIYRKPRTGDLMEGDRP--EIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTV 634
++F I R+P L E ++G+I F NV F YP RP + L G+T
Sbjct: 417 IIFETIDREPEIDCLSEAGYKLDRVKGDIEFHNVTFHYPSRPEVKTLDQLSVAVKSGETT 476
Query: 633 ALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGT 454
A VGPSG+GKST I + +RFYD G + +DG DIR L++ LR+ + +V QEP LFA T
Sbjct: 477 AFVGPSGAGKSTAIQLFQRFYDPKEGMVTLDGHDIRGLNIQWLRSLIGIVEQEPVLFATT 536
Query: 453 IRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIAR 274
I EN+C G V +E I A + ANA F+ +LP +T VGE GGQ+SGGQKQRIAIAR
Sbjct: 537 IAENICYGRPGVSMEDIVAAAKEANAYHFIQDLPQKFNTMVGEGGGQMSGGQKQRIAIAR 596
Query: 273 ALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDK 94
ALVR+P+ILLLD ATSALD+ESE VQEALD+ R GRT I+IAHRLS+I+N+D+IV +
Sbjct: 597 ALVRNPRILLLDMATSALDNESEAIVQEALDKVRLGRTTISIAHRLSTIKNADVIVGFEH 656
Query: 93 GKVQEAGNHTQLMHQKGRYYKLIKKQ 16
G+ E G H +L+ +KG Y+ L+ Q
Sbjct: 657 GRAVEKGKHGELLERKGVYFMLVTLQ 682
>gi|157873|gb|AAA16186.1| P-glycoprotein/multidrug resistance protein
Length = 1283
Score = 693 bits (1788), Expect = 0.0
Identities = 425/1277 (33%), Positives = 677/1277 (52%), Gaps = 37/1277 (2%)
Frame = -1
Query: 3735 EAQPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYP---PTS 3565
+ + VS LFRY K D L IG + A+ +G++ P +L+ G + N ++ +
Sbjct: 40 DVKQVSYFQLFRYATKKDRALYVIGLLSAVGTGLTTPANSLIFGNLANDMIDLSGLLESG 99
Query: 3564 KQFR----------NKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYS 3415
K +R +K + IG+ + + +++ CF + + +R +F S
Sbjct: 100 KSYRADDAISTLLLDKVRQFSLQNTYIGMIMLVCSYLSITCFNYAAHSQILTIRSKFFRS 159
Query: 3414 VLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRL 3235
+L Q+ W+D N SG + +++N+ + ++ +G+ +K+ + + + ++V+A++ W+L
Sbjct: 160 ILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQL 219
Query: 3234 ASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMV 3055
+ + L P I M L+A + KE+ A +AE +L G+RTV+AF G+ + V
Sbjct: 220 SLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEV 279
Query: 3054 GRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLK----VGIITTP- 2890
Y+ + + + + +Y +Y L VG++
Sbjct: 280 AAYKERVVAAKILNIKRNMFSGIGFGLLWFF--------FIYASYALAFWYGVGLVIESA 331
Query: 2889 ------GDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAG 2728
G + V S+++G+ +G+ +P++ A+ ++ I+++P+I+P
Sbjct: 332 YENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAQGRLPKVFHIIEQIPEINPLMGRV 391
Query: 2727 KRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTR 2548
K + + ++F+ V F+YP+R + ILN LNL + G +VALVG SGCGKST + L+ R
Sbjct: 392 K-VNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQR 450
Query: 2547 LYEPEAGNVTIDGTDVRELNIEWLRNT-VGIVQQEPILFNDTIHNNLLIGNPGSTRETMI 2371
Y+P+AGN+ +GT++++L+I WLR +G+V QEPILF +I+ N+ G +TRE +
Sbjct: 451 FYDPQAGNLLFNGTNLKDLDINWLRFLRIGVVGQEPILFATSIYENIRYGREDATREEIE 510
Query: 2370 EVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSAL 2191
ANA FI+K+PKGYDTL+G+ G QLSGGQKQR+AI R LIRDP++LLLDEATSAL
Sbjct: 511 AARAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIRRALIRDPEILLLDEATSAL 570
Query: 2190 DAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGR 2011
D SE+ VQ+AL S GRTTI++AHRLST+R AD+IV KG +VE+G H+EL+ L
Sbjct: 571 DTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDH 630
Query: 2010 YFDLVKAQQFKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFS 1831
YF+LV Q + D + D + + D +
Sbjct: 631 YFNLVTTQLGEDDGSVLSPTGDIYKNFDIKDEDEEEIKVLSEDEDEDVM-----VTDEKN 685
Query: 1830 GSKRSXXXXXXXXXXXXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLE 1651
K+ +D L++ K K +L + +G + ++I G
Sbjct: 686 KKKK----------------MKKVKDPNEVKPMLEVMKMNKPEWLQIAVGCISSVIMGCA 729
Query: 1650 LPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENL 1471
+P A++FG + + + + + F G+ V + F + E L
Sbjct: 730 MPIFAVLFGSILQILSVKDNDQYVRENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERL 789
Query: 1470 SMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXX 1291
+ R R F +L Q+ ++FD+ A+ G L RL+ DA ++ R+ +
Sbjct: 790 TERLRGLMFEAMLRQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIIQSISTLA 849
Query: 1290 XXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQ----NDDAGRIAIEII 1123
Y W F++I + +LM E ++ ++ ++A+E++
Sbjct: 850 LGIALSMYYEW---SLGLVALAFTPFILIAFYMQRTLMAKENMRPAKTMENCTKLAVEVV 906
Query: 1122 ENVKTIQLLTRCELFFDHY----QTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTY 955
N++T+ L R E+F +Y + + KR+ +G++ Y L +S M+F
Sbjct: 907 SNIRTVASLGREEMFHQNYIGMLIPAVEISKRNTHFRGLV----YGLARSLMFFAYAACM 962
Query: 954 AVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPR 775
G + D FK A+++G ++ N+ + P K +AA +F + R+P
Sbjct: 963 YYGTWCVIHRGILFGDVFKVSQAVIMGTASIANALAFAPNMQKGVSAAKTIFTFLRRQPS 1022
Query: 774 TGDL--MEGDRPEIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKS 601
D + D G + F+ VKFSYP R ++KGL+ +GQ +ALVGPSG GKS
Sbjct: 1023 IVDRPGVSRDPWHSEGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKS 1082
Query: 600 TNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG--L 427
T I +++RFYDV GA ID D+R +S+ +LR Q+ +V QEP LF TIREN+ G
Sbjct: 1083 TCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNA 1142
Query: 426 KDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKIL 247
++V ++I A + +N + F+ANLP G DT +GEKG QLSGGQKQRIAIARAL+R+PKI+
Sbjct: 1143 RNVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIM 1202
Query: 246 LLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNH 67
LLDEATSALD+ESE+ VQ+ALD A EGRT I+IAHRLS++ +SD+I + G V EAG+H
Sbjct: 1203 LLDEATSALDAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDH 1262
Query: 66 TQLMHQKGRYYKLIKKQ 16
QL+ +G YY L K Q
Sbjct: 1263 KQLLANRGLYYTLYKLQ 1279
>gi|1079107|pir||A47377 multidrug resistance protein Mdr50 - fruit fly
(Drosophila melanogaster)
Length = 1283
Score = 693 bits (1788), Expect = 0.0
Identities = 425/1277 (33%), Positives = 677/1277 (52%), Gaps = 37/1277 (2%)
Frame = -1
Query: 3735 EAQPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYP---PTS 3565
+ + VS LFRY K D L IG + A+ +G++ P +L+ G + N ++ +
Sbjct: 40 DVKQVSYFQLFRYATKKDRALYVIGLLSAVGTGLTTPANSLIFGNLANDMIDLSGLLESG 99
Query: 3564 KQFR----------NKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYS 3415
K +R +K + IG+ + + +++ CF + + +R +F S
Sbjct: 100 KSYRADDAISTLLLDKVRQFSLQNTYIGMIMLVCSYLSITCFNYAAHSQILTIRSKFFRS 159
Query: 3414 VLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRL 3235
+L Q+ W+D N SG + +++N+ + ++ +G+ +K+ + + + ++V+A++ W+L
Sbjct: 160 ILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQL 219
Query: 3234 ASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMV 3055
+ + L P I M L+A + KE+ A +AE +L G+RTV+AF G+ + V
Sbjct: 220 SLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEV 279
Query: 3054 GRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLK----VGIITTP- 2890
Y+ + + + + +Y +Y L VG++
Sbjct: 280 AAYKERVVAAKILNIKRNMFSGIGFGLLWFF--------FIYASYALAFWYGVGLVIESA 331
Query: 2889 ------GDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAG 2728
G + V S+++G+ +G+ +P++ A+ ++ I+++P+I+P
Sbjct: 332 YENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAQGRLPKVFHIIEQIPEINPLMGRV 391
Query: 2727 KRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTR 2548
K + + ++F+ V F+YP+R + ILN LNL + G +VALVG SGCGKST + L+ R
Sbjct: 392 K-VNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQR 450
Query: 2547 LYEPEAGNVTIDGTDVRELNIEWLRNT-VGIVQQEPILFNDTIHNNLLIGNPGSTRETMI 2371
Y+P+AGN+ +GT++++L+I WLR +G+V QEPILF +I+ N+ G +TRE +
Sbjct: 451 FYDPQAGNLLFNGTNLKDLDINWLRFLRIGVVGQEPILFATSIYENIRYGREDATREEIE 510
Query: 2370 EVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSAL 2191
ANA FI+K+PKGYDTL+G+ G QLSGGQKQR+AI R LIRDP++LLLDEATSAL
Sbjct: 511 AARAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIRRALIRDPEILLLDEATSAL 570
Query: 2190 DAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGR 2011
D SE+ VQ+AL S GRTTI++AHRLST+R AD+IV KG +VE+G H+EL+ L
Sbjct: 571 DTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDH 630
Query: 2010 YFDLVKAQQFKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFS 1831
YF+LV Q + D + D + + D +
Sbjct: 631 YFNLVTTQLGEDDGSVLSPTGDIYKNFDIKDEDEEEIKVLSEDEDEDVM-----VTDEKN 685
Query: 1830 GSKRSXXXXXXXXXXXXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLE 1651
K+ +D L++ K K +L + +G + ++I G
Sbjct: 686 KKKK----------------MKKVKDPNEVKPMLEVMKMNKPEWLQIAVGCISSVIMGCA 729
Query: 1650 LPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENL 1471
+P A++FG + + + + + F G+ V + F + E L
Sbjct: 730 MPIFAVLFGSILQILSVKDNDQYVRENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERL 789
Query: 1470 SMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXX 1291
+ R R F +L Q+ ++FD+ A+ G L RL+ DA ++ R+ +
Sbjct: 790 TERLRGLMFEAMLRQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIIQSISTLA 849
Query: 1290 XXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQ----NDDAGRIAIEII 1123
Y W F++I + +LM E ++ ++ ++A+E++
Sbjct: 850 LGIALSMYYEW---SLGLVALAFTPFILIAFYMQRTLMAKENMRPAKTMENCTKLAVEVV 906
Query: 1122 ENVKTIQLLTRCELFFDHY----QTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTY 955
N++T+ L R E+F +Y + + KR+ +G++ Y L +S M+F
Sbjct: 907 SNIRTVASLGREEMFHQNYIGMLIPAVEISKRNTHFRGLV----YGLARSLMFFAYAACM 962
Query: 954 AVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPR 775
G + D FK A+++G ++ N+ + P K +AA +F + R+P
Sbjct: 963 YYGTWCVIHRGILFGDVFKVSQAVIMGTASIANALAFAPNMQKGVSAAKTIFTFLRRQPS 1022
Query: 774 TGDL--MEGDRPEIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKS 601
D + D G + F+ VKFSYP R ++KGL+ +GQ +ALVGPSG GKS
Sbjct: 1023 IVDRPGVSRDPWHSEGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKS 1082
Query: 600 TNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG--L 427
T I +++RFYDV GA ID D+R +S+ +LR Q+ +V QEP LF TIREN+ G
Sbjct: 1083 TCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNA 1142
Query: 426 KDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKIL 247
++V ++I A + +N + F+ANLP G DT +GEKG QLSGGQKQRIAIARAL+R+PKI+
Sbjct: 1143 RNVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIM 1202
Query: 246 LLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNH 67
LLDEATSALD+ESE+ VQ+ALD A EGRT I+IAHRLS++ +SD+I + G V EAG+H
Sbjct: 1203 LLDEATSALDAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDH 1262
Query: 66 TQLMHQKGRYYKLIKKQ 16
QL+ +G YY L K Q
Sbjct: 1263 KQLLANRGLYYTLYKLQ 1279
>gi|50507726|emb|CAA94219.3| Hypothetical protein T21E8.2
[Caenorhabditis elegans]
Length = 1263
Score = 685 bits (1767), Expect = 0.0
Identities = 421/1259 (33%), Positives = 670/1259 (52%), Gaps = 24/1259 (1%)
Frame = -1
Query: 3708 LFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGR-------VTNAL---LVYPPTSKQ 3559
+F+ F+ L IG ++++G+ QP ++ G +TNA+ + P K+
Sbjct: 31 IFKCTSCFEKFLFLIGVFFSLVTGLCQPFVSYTLGETAQVLVTITNAINNKTIDPADLKK 90
Query: 3558 FRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMA-----QMRHRFVYSVLRQNAG 3394
+ +Y + + F+ + + QH + + ++R +++ +LR++A
Sbjct: 91 AYEQYERGMYQVV-LYFFLCGCAYFTFASIQHAIMKYVGDNTTYRVRKQYISRLLRKDAE 149
Query: 3393 WFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGV 3214
+FD +G ++T LND++ER RE +K+ ++ + +A+ +WRLAS +
Sbjct: 150 YFDNVSTGHLSTVLNDNLERFREVFNEKIALIFALLTDFVVGTALAFYTDWRLASYGIFF 209
Query: 3213 APTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAEL 3034
+ + + + TT K+ AGSIA ++L +TV + NGQ + RY EL
Sbjct: 210 SLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQNTEIERYTEEL 269
Query: 3033 EKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLL 2854
+ G K+ + + + GA ++ G + P V + M+
Sbjct: 270 KAGEKYGIHRALMYSISRGFTYFFCNSLNTVILYVGANMIYSGSLE-PAVVVRIFHYMMF 328
Query: 2853 GAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQ-NVVGRVKFENVHF 2677
GA+ L PH+ L A S A I + + + + + ++ V G + F+NV F
Sbjct: 329 GAFCLSEALPHISRLAGAISSTAPIAEMLIKEDNVIEKDETDYDVEVEVNGNISFKNVKF 388
Query: 2676 RYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVR 2497
YP+R DA++L G++ V+ G +ALVG SG GKST V LL Y ++GN+ IDG D+
Sbjct: 389 SYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLN 448
Query: 2496 ELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKG 2317
++NI+ LR +G+V QEP+LFN TI N+ GNP + + + ANA+DF+ PKG
Sbjct: 449 DMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKG 508
Query: 2316 YDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKG 2137
T++G+ G QLSGGQKQR+AIARTL+R+PK+LLLDEATSALD +SE +VQ AL NAS+G
Sbjct: 509 IKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQG 568
Query: 2136 RTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKADPXXXX 1957
RTTI++AHRLSTIR A KI+ +KG IVE GNH+EL+ G Y DLV+AQ ++
Sbjct: 569 RTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLESHDDHEE 628
Query: 1956 XXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXXXXXXXXX 1777
L S S++ + +
Sbjct: 629 LPPLAARQLSQEL----------------------SPLHSYAIQRSTSNDAGVHDDDMER 666
Query: 1776 XXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFV 1597
++G + +I K + +Y ++F+ + I+G+ P LA + +EGF +
Sbjct: 667 ILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMI 726
Query: 1596 PYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDAS 1417
G M++ + ++F + V + F VSE LS R R++SF ++L +
Sbjct: 727 --GEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCA 784
Query: 1416 YFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXX 1237
++D+P H+ +L RL +D+ N+KA VD R+ V +YCW+
Sbjct: 785 FYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVL 844
Query: 1236 XXXXXLAFVMIGLA-YKISLMNVEQIQND-----DAGRIAIEIIENVKTIQLLTRCELFF 1075
F ++ LA Y IQ D ++ R AIE +EN++T++ L +
Sbjct: 845 IF-----FPLLYLAEYCYDAATETSIQEDTIAFENSNRTAIEALENMRTVRALNLEDKIM 899
Query: 1074 DHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKG 895
++ +S K+ +I+ L+ S F+ ++ G + + + + DT+
Sbjct: 900 SLISEHLQKIHKSYFKRAIIQGAANGLSLSCYLFVYSVSFKFGTYLALRKEVAPMDTYLI 959
Query: 894 IIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNII-YRKPRTGDLMEGDRPEIRGNILFE 718
+ + + A ++A Y P++ KA AAG++F++ Y +G + +G I+ E
Sbjct: 960 LETLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGE 1019
Query: 717 NVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDG 538
NV+F Y QRP + I+ G+ G+T+ALVGPSG GKST I +LERFY G ++ID
Sbjct: 1020 NVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDS 1079
Query: 537 QDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGL-KDVPLEKINQALELANANRFLA 361
+++ ++L HLR+ +ALV QEP LF +IREN+ GL + VP ++ +AL+ ANA F+
Sbjct: 1080 ENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVF 1139
Query: 360 NLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALD 181
P G+DT VGE+G QLSGGQKQRIAIARA++R+PK+LLLDEATSALDS+SE+ VQ ALD
Sbjct: 1140 QFPQGLDTIVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALD 1199
Query: 180 RAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQDLAV 4
A E + + +AHRL ++ N+D I + GKV E G H +L+ ++ Y++L++KQ + V
Sbjct: 1200 TASERLSTVVVAHRLLTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQV 1258
Score = 295 bits (756), Expect = 5e-78
Identities = 186/574 (32%), Positives = 296/574 (51%), Gaps = 3/574 (0%)
Frame = -1
Query: 3684 DYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKANENVYIFLGIGIF 3505
DY LFI + I GVS PILA + R + + + F+ + +F
Sbjct: 691 DYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYYSHLW---ALSFMFLAVF 747
Query: 3504 ISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFDK-NHSGT-ITTKLNDSMERI 3331
+T + QY F ++ ++R + +L ++D NHS T ++ +LN +
Sbjct: 748 RPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNV 807
Query: 3330 REGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIK 3151
+ + D+LG ++ + AI A +Y W++ +L P + ++ +
Sbjct: 808 KAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLIFFPLLYLAEYCYDAATETSIQE 867
Query: 3150 ELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXX 2971
+ I + A E+L +RTV+A N +++++ L+K K +
Sbjct: 868 DTIAFENSNRTAIEALENMRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLS 927
Query: 2970 XXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVS 2791
+G YL + P D ++++ ++ + A G + ++ A V
Sbjct: 928 LSCYLFVYSVSFKFGTYLALRKEVA-PMDTYLILETLSMTANMAGSAAAYLPDYKKA-VH 985
Query: 2790 AASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGT 2611
AA + + P P+S + + G + ENV F Y R D ILNG+NL V+PG
Sbjct: 986 AAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGK 1045
Query: 2610 SVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFN 2431
++ALVG SGCGKST + LL R Y G V ID +V ++N+ LR+ + +V QEP LFN
Sbjct: 1046 TLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFN 1105
Query: 2430 DTIHNNLLIGNPGSTRETMIE-VCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVA 2254
+I NLL G S + +E + ANA +F+ + P+G DT++G+ G QLSGGQKQR+A
Sbjct: 1106 CSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTIVGERGAQLSGGQKQRIA 1165
Query: 2253 IARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVF 2074
IAR ++R+PKVLLLDEATSALD+ SE +VQ+AL+ AS+ +T+++AHRL T+ AD I
Sbjct: 1166 IARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLLTVVNADSIAV 1225
Query: 2073 FEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKAD 1972
+ G + E G HEEL+R Y+ LV+ Q + +
Sbjct: 1226 LKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQVE 1259
>gi|27368859|emb|CAD59587.1| MDR-like ABC transporter [Oryza sativa
(japonica cultivar-group)]
Length = 1264
Score = 679 bits (1751), Expect = 0.0
Identities = 427/1261 (33%), Positives = 664/1261 (51%), Gaps = 27/1261 (2%)
Frame = -1
Query: 3723 VSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKA 3544
V + LFRY + D LL+ +GT+ A+ +G+SQP++ ++ G V N+ TS
Sbjct: 31 VPLFSLFRYADRLDVLLMVVGTVGALGNGISQPLMTVLFGNVINSFGAN--TSGSVLRSV 88
Query: 3543 NENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFDKNHS-GT 3367
+ V F+ +GI S+ +F+Q C+ R A++R ++ +VLRQ+ +FD + G
Sbjct: 89 TKVVLNFIYLGIGTSVASFLQVSCWTMAGERQSARIRSLYLKAVLRQDITFFDTEMTTGE 148
Query: 3366 ITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMS 3187
++++ I+ +G+K G L+ + I ++A+ W L +ML P I +
Sbjct: 149 AVSRMSSDTLLIQGALGEKGGKLVELLSSFIGGFIIAFTRGWLLTLVMLTSLPLIAIASA 208
Query: 3186 LLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVW 3007
+ A+ +T + K AG E+++ +RTV +FNG+++ + Y ++K K +
Sbjct: 209 VSAQALTRVSSKRQTSYSDAGDTVEQTIGSIRTVVSFNGEKKAIAMYRNFIKKSYKATIE 268
Query: 3006 KXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLIS 2827
+ G YG L+ + T G + ++ ++L GA LG +
Sbjct: 269 EGIITGFGMGSVMCVVFGSYGLAFWYGGKLI-IEKGYTGGKIMTILFAVLTGASSLGNAT 327
Query: 2826 PHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKI 2647
P + ++ + +A ++++TI+R P+ID G L+++ G ++ ++V+FRYP+R + I
Sbjct: 328 PAVAAVVEGQSAAYNLFKTIERKPEIDSDDNNGMVLEDMNGDIELKDVYFRYPARPEQLI 387
Query: 2646 LNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNT 2467
L+GL+L V GT++A+VG SG GKST + L+ R Y+P++G V IDG +++L ++W+R
Sbjct: 388 LDGLSLQVASGTTMAIVGESGSGKSTVISLVERFYDPQSGEVLIDGISIKKLRLDWIRGK 447
Query: 2466 VGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGV 2287
+G+V QEP+LF +I +N++ G +T E + ++ANA +FI+K+P GYDTL+G G
Sbjct: 448 IGLVSQEPLLFMASIKDNIIYGKKDATLEEIKRAAELANAANFIDKLPNGYDTLVGQRGT 507
Query: 2286 QLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRL 2107
QLSGGQKQR+AIAR +++DPK+LLLDEATSALD +SE IVQ ALN RTT+++AHRL
Sbjct: 508 QLSGGQKQRIAIARAILKDPKILLLDEATSALDVESERIVQEALNRMMVERTTLVVAHRL 567
Query: 2106 STIREADKIVFFEKGVIVEAGNHEELVR-LGGRYFDLVKAQQFKADPXXXXXXXXXEIDL 1930
ST+R D I KG IVE G H+ LV+ G Y L++ Q+ D L
Sbjct: 568 STVRNVDCITVVRKGKIVEQGPHDALVKDPDGAYSQLIRLQETHRDERH---------KL 618
Query: 1929 DDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXXXXXXXXXXXXXXXEDG 1750
D+ +FRR + D S S R E
Sbjct: 619 PDSRSKSTSL----------SFRRSRT-KDFLSKSNRYSFKSPLGLPVDIHEDGMTSEQQ 667
Query: 1749 QI------------TAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGF 1606
++ + +F K + LG++ A + G+ LP +I V + F
Sbjct: 668 KVDHSDNSDSKAIKKTPFGRLFNLNKPEVPVLLLGSIAASVHGVILPLYGIIMPGVLKSF 727
Query: 1605 TFVPYGGRMMHRM--AMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLL 1432
P R R M+V+ +GV S A LF + L R R SF+ ++
Sbjct: 728 YEPPDQLRKDSRFWALMSVV----LGVACLISIPAEYFLFGIAGGKLIQRVRTLSFQRIM 783
Query: 1431 YQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQX 1252
+Q+ ++FD P+++ G L TRL+ DA N++ +V + + W+
Sbjct: 784 HQEVAWFDKPSNSSGALGTRLSVDALNVRRLVGDNLALIVQAVATLITGFAIAFAADWRL 843
Query: 1251 XXXXX---XXXXXLAFVMIGLAYKISLMNVEQIQNDDAGRIAIEIIENVKTIQLLTRCEL 1081
+ + S + E +DA ++A + + +++T+ +
Sbjct: 844 ALIITCVIPLVGAQGYAQVKFLKGFSEESKEMY--EDANQVAADAVGSIRTVASFCSEKR 901
Query: 1080 FFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTF 901
Y + ++ ++ G++ I S + +Y + VG + + QG + D F
Sbjct: 902 VVAIYNKKCEALRKQGIRSGIVGGIGLSFSNLMLYLTYGLCFYVGAKFVSQGKTTFSDVF 961
Query: 900 KGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPR------TGDLMEGDRPEI 739
K A++L AV V S+ KA+ +A +F+II RK R G +ME +
Sbjct: 962 KVFFALVLAAVGVSQSSALSTNATKARDSAISIFSIIDRKSRIDSSSDEGAIME----NV 1017
Query: 738 RGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTG 559
G+I F NV F YP RP I +T+ALVG SGSGKST I +LERFYD
Sbjct: 1018 TGSIDFNNVSFKYPSRPDVQIFSDFTLHIPSQKTIALVGESGSGKSTIIALLERFYDPDS 1077
Query: 558 GALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGL-KDVPLEKINQALELA 382
G + +DG +IR L + LR QM LVGQEP LF TIR N+ G +V E+I + A
Sbjct: 1078 GNISLDGVEIRSLKVSWLRDQMGLVGQEPVLFNDTIRANITYGKHSEVTEEEITAVAKAA 1137
Query: 381 NANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESER 202
NA+ F+++LP G DT VGEKG QLSGGQKQR+AIARA+++DPKILLLDEATSALD+ESER
Sbjct: 1138 NAHEFVSSLPQGYDTVVGEKGVQLSGGQKQRVAIARAILKDPKILLLDEATSALDAESER 1197
Query: 201 AVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQK-GRYYKLI 25
VQ+ALDR RT I +AHRLS+I+ +D+I + +GK+ E G H L+ K G Y L+
Sbjct: 1198 VVQDALDRVMVNRTTIVVAHRLSTIKGADMIAVLKEGKIAEKGKHEALLRIKDGAYASLV 1257
Query: 24 K 22
+
Sbjct: 1258 Q 1258
Score = 295 bits (756), Expect = 5e-78
Identities = 193/570 (33%), Positives = 298/570 (51%), Gaps = 8/570 (1%)
Frame = -1
Query: 1698 LYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWF 1519
L M +GTV AL G+ P + ++FG V F G ++ + V+ F +G+G
Sbjct: 46 LLMVVGTVGALGNGISQPLMTVLFGNVINSFG-ANTSGSVLRSVTKVVLNFIYLGIGTSV 104
Query: 1518 SQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAV 1339
+ + + E S R R + +L QD ++FD G+ ++R++SD I+
Sbjct: 105 ASFLQVSCWTMAGERQSARIRSLYLKAVLRQDITFFDTEM-TTGEAVSRMSSDTLLIQGA 163
Query: 1338 VDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVE-QI 1162
+ + ++ W +A A ++ ++ + Q
Sbjct: 164 LGEKGGKLVELLSSFIGGFIIAFTRGWLLTLVMLTSLPLIAIASAVSAQALTRVSSKRQT 223
Query: 1161 QNDDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSF 982
DAG + I +++T+ + Y+ K+ ++ +++G+I
Sbjct: 224 SYSDAGDTVEQTIGSIRTVVSFNGEKKAIAMYRNFIKKSYKATIEEGIITGFGMGSVMCV 283
Query: 981 MYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGML 802
++ + G ++I + + + A++ GA ++ N+ V+ ++AA L
Sbjct: 284 VFGSYGLAFWYGGKLIIEKGYTGGKIMTILFAVLTGASSLGNATPAVAAVVEGQSAAYNL 343
Query: 801 FNIIYRKPR------TGDLMEGDRPEIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQ 640
F I RKP G ++E ++ G+I ++V F YP RP Q I+ GL G
Sbjct: 344 FKTIERKPEIDSDDNNGMVLE----DMNGDIELKDVYFRYPARPEQLILDGLSLQVASGT 399
Query: 639 TVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFA 460
T+A+VG SGSGKST I ++ERFYD G + IDG I+KL L +R ++ LV QEP LF
Sbjct: 400 TMAIVGESGSGKSTVISLVERFYDPQSGEVLIDGISIKKLRLDWIRGKIGLVSQEPLLFM 459
Query: 459 GTIRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAI 280
+I++N+ G KD LE+I +A ELANA F+ LP G DT VG++G QLSGGQKQRIAI
Sbjct: 460 ASIKDNIIYGKKDATLEEIKRAAELANAANFIDKLPNGYDTLVGQRGTQLSGGQKQRIAI 519
Query: 279 ARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYI 100
ARA+++DPKILLLDEATSALD ESER VQEAL+R RT + +AHRLS+++N D I +
Sbjct: 520 ARAILKDPKILLLDEATSALDVESERIVQEALNRMMVERTTLVVAHRLSTVRNVDCITVV 579
Query: 99 DKGKVQEAGNHTQLMHQ-KGRYYKLIKKQD 13
KGK+ E G H L+ G Y +LI+ Q+
Sbjct: 580 RKGKIVEQGPHDALVKDPDGAYSQLIRLQE 609
>gi|17569909|ref|NP_509812.1| P-GlycoProtein related (pgp-7)
[Caenorhabditis elegans]
Length = 1269
Score = 679 bits (1751), Expect = 0.0
Identities = 422/1265 (33%), Positives = 670/1265 (52%), Gaps = 30/1265 (2%)
Frame = -1
Query: 3708 LFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGR-------VTNAL---LVYPPTSKQ 3559
+F+ F+ L IG ++++G+ QP ++ G +TNA+ + P K+
Sbjct: 31 IFKCTSCFEKFLFLIGVFFSLVTGLCQPFVSYTLGETAQVLVTITNAINNKTIDPADLKK 90
Query: 3558 FRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMA-----QMRHRFVYSVLRQNAG 3394
+ +Y + + F+ + + QH + + ++R +++ +LR++A
Sbjct: 91 AYEQYERGMYQVV-LYFFLCGCAYFTFASIQHAIMKYVGDNTTYRVRKQYISRLLRKDAE 149
Query: 3393 WFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGV 3214
+FD +G ++T LND++ER RE +K+ ++ + +A+ +WRLAS +
Sbjct: 150 YFDNVSTGHLSTVLNDNLERFREVFNEKIALIFALLTDFVVGTALAFYTDWRLASYGIFF 209
Query: 3213 APTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAEL 3034
+ + + + TT K+ AGSIA ++L +TV + NGQ + RY EL
Sbjct: 210 SLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQNTEIERYTEEL 269
Query: 3033 EKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLL 2854
+ G K+ + + + GA ++ G + P V + M+
Sbjct: 270 KAGEKYGIHRALMYSISRGFTYFFCNSLNTVILYVGANMIYSGSLE-PAVVVRIFHYMMF 328
Query: 2853 GAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQ-NVVGRVKFENVHF 2677
GA+ L PH+ L A S A I + + + + + ++ V G + F+NV F
Sbjct: 329 GAFCLSEALPHISRLAGAISSTAPIAEMLIKEDNVIEKDETDYDVEVEVNGNISFKNVKF 388
Query: 2676 RYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVR 2497
YP+R DA++L G++ V+ G +ALVG SG GKST V LL Y ++GN+ IDG D+
Sbjct: 389 SYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLN 448
Query: 2496 ELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKG 2317
++NI+ LR +G+V QEP+LFN TI N+ GNP + + + ANA+DF+ PKG
Sbjct: 449 DMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKG 508
Query: 2316 YDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKG 2137
T++G+ G QLSGGQKQR+AIARTL+R+PK+LLLDEATSALD +SE +VQ AL NAS+G
Sbjct: 509 IKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQG 568
Query: 2136 RTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKADPXXXX 1957
RTTI++AHRLSTIR A KI+ +KG IVE GNH+EL+ G Y DLV+AQ ++
Sbjct: 569 RTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLESHDDHEE 628
Query: 1956 XXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXXXXXXXXX 1777
L S S++ + +
Sbjct: 629 LPPLAARQLSQEL----------------------SPLHSYAIQRSTSNDAGVHDDDMER 666
Query: 1776 XXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFV 1597
++G + +I K + +Y ++F+ + I+G+ P LA + +EGF +
Sbjct: 667 ILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMI 726
Query: 1596 PYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDAS 1417
G M++ + ++F + V + F VSE LS R R++SF ++L +
Sbjct: 727 --GEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCA 784
Query: 1416 YFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXX 1237
++D+P H+ +L RL +D+ N+KA VD R+ V +YCW+
Sbjct: 785 FYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVL 844
Query: 1236 XXXXXLAFVMIGLA-YKISLMNVEQIQND-----DAGRIAIEIIENVKTIQLLTRCELFF 1075
F ++ LA Y IQ D ++ R AIE +EN++T++ L +
Sbjct: 845 IF-----FPLLYLAEYCYDAATETSIQEDTIAFENSNRTAIEALENMRTVRALNLEDKIM 899
Query: 1074 DHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKG 895
++ +S K+ +I+ L+ S F+ ++ G + + + + DT+
Sbjct: 900 SLISEHLQKIHKSYFKRAIIQGAANGLSLSCYLFVYSVSFKFGTYLALRKEVAPMDTYLI 959
Query: 894 IIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNII-YRKPRTGDLMEGDRPEIRGNILFE 718
+ + + A ++A Y P++ KA AAG++F++ Y +G + +G I+ E
Sbjct: 960 LETLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGE 1019
Query: 717 NVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGG------ 556
NV+F Y QRP + I+ G+ G+T+ALVGPSG GKST I +LERFY G
Sbjct: 1020 NVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVVSID 1079
Query: 555 ALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGL-KDVPLEKINQALELAN 379
A +ID +++ ++L HLR+ +ALV QEP LF +IREN+ GL + VP ++ +AL+ AN
Sbjct: 1080 AHKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTAN 1139
Query: 378 ANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERA 199
A F+ P G+DT VGE+G QLSGGQKQRIAIARA++R+PK+LLLDEATSALDS+SE+
Sbjct: 1140 AFNFVFQFPQGLDTIVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKV 1199
Query: 198 VQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKK 19
VQ ALD A E + + +AHRL ++ N+D I + GKV E G H +L+ ++ Y++L++K
Sbjct: 1200 VQNALDTASERLSTVVVAHRLLTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQK 1259
Query: 18 QDLAV 4
Q + V
Sbjct: 1260 QGIQV 1264
Score = 289 bits (740), Expect = 3e-76
Identities = 186/580 (32%), Positives = 296/580 (50%), Gaps = 9/580 (1%)
Frame = -1
Query: 3684 DYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKANENVYIFLGIGIF 3505
DY LFI + I GVS PILA + R + + + F+ + +F
Sbjct: 691 DYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYYSHLW---ALSFMFLAVF 747
Query: 3504 ISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFDK-NHSGT-ITTKLNDSMERI 3331
+T + QY F ++ ++R + +L ++D NHS T ++ +LN +
Sbjct: 748 RPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNV 807
Query: 3330 REGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIK 3151
+ + D+LG ++ + AI A +Y W++ +L P + ++ +
Sbjct: 808 KAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLIFFPLLYLAEYCYDAATETSIQE 867
Query: 3150 ELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXX 2971
+ I + A E+L +RTV+A N +++++ L+K K +
Sbjct: 868 DTIAFENSNRTAIEALENMRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLS 927
Query: 2970 XXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVS 2791
+G YL + P D ++++ ++ + A G + ++ A V
Sbjct: 928 LSCYLFVYSVSFKFGTYLALRKEVA-PMDTYLILETLSMTANMAGSAAAYLPDYKKA-VH 985
Query: 2790 AASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGT 2611
AA + + P P+S + + G + ENV F Y R D ILNG+NL V+PG
Sbjct: 986 AAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGK 1045
Query: 2610 SVALVGHSGCGKSTSVGLLTRLYEPEAGNVT------IDGTDVRELNIEWLRNTVGIVQQ 2449
++ALVG SGCGKST + LL R Y G V ID +V ++N+ LR+ + +V Q
Sbjct: 1046 TLALVGPSGCGKSTIISLLERFYHAVDGEVVSIDAHKIDSENVEDINLNHLRSNLALVSQ 1105
Query: 2448 EPILFNDTIHNNLLIGNPGSTRETMIE-VCKMANAHDFIEKMPKGYDTLIGDGGVQLSGG 2272
EP LFN +I NLL G S + +E + ANA +F+ + P+G DT++G+ G QLSGG
Sbjct: 1106 EPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTIVGERGAQLSGG 1165
Query: 2271 QKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIRE 2092
QKQR+AIAR ++R+PKVLLLDEATSALD+ SE +VQ+AL+ AS+ +T+++AHRL T+
Sbjct: 1166 QKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLLTVVN 1225
Query: 2091 ADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKAD 1972
AD I + G + E G HEEL+R Y+ LV+ Q + +
Sbjct: 1226 ADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQVE 1265
>gi|19032275|dbj|BAB85651.1| multidrug resistance protein 1 homolog
[Triticum aestivum]
Length = 1262
Score = 672 bits (1734), Expect = 0.0
Identities = 411/1254 (32%), Positives = 661/1254 (51%), Gaps = 20/1254 (1%)
Frame = -1
Query: 3723 VSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKA 3544
V + G+FRY + D LL+ +G++ A+ +GVS+P+++++ G V N+ T+
Sbjct: 28 VPLLGMFRYADRLDMLLMVVGSLGAVGNGVSEPLISVLFGDVINSF--GESTTSTVLRAV 85
Query: 3543 NENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFDKNHS-GT 3367
+ V F+ +GI ++ +F+Q C+ R A++R ++ SVLRQ+ +FD + G
Sbjct: 86 TKVVLNFIYLGIGTAVASFLQVACWTMAGERQSARIRSLYLKSVLRQDIAFFDTEMTTGE 145
Query: 3366 ITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMS 3187
++++ I++ +G+K G L++ + ++A+ W L +ML P I +
Sbjct: 146 AVSRMSSDTVIIQDALGEKAGKLVQLTSAFFGGFIIAFTKGWLLTLVMLTSLPLVAIAGA 205
Query: 3186 LLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVW 3007
+ A+ +T + K L A + E+++ +RTV +FNG+++ + Y ++ + V
Sbjct: 206 VSAQMLTRVSSKRLTSYSDAANTVEQTIGSIRTVVSFNGEKKAIEMYNKFIKSAYRTVVE 265
Query: 3006 KXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLIS 2827
+ G YG L+ + T G + V+ ++L GA LG +
Sbjct: 266 EGLVNGFGMGSVFCILFSSYGLAFWYGGKLI-IDKGYTGGKIVTVLFAVLNGATSLGNAT 324
Query: 2826 PHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKI 2647
P + + + +A +++TI+R P+ID +G ++N+ G V+ ++V+FRYP+R I
Sbjct: 325 PSISAIAEGQSAAYRLFETIERKPEIDSDDTSGMIMENIKGYVELKDVYFRYPARLGQLI 384
Query: 2646 LNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNT 2467
L+GL+L V GT++A+VG SG GKST + L+ R Y+P+AG V IDG +++ LN++W+R
Sbjct: 385 LDGLSLQVASGTTMAIVGESGSGKSTVISLVERFYDPQAGEVLIDGVNIKNLNLDWIRGK 444
Query: 2466 VGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGV 2287
+G+V QEP+LF +I +N++ G +T E + ++ANA +FI+K+P GYDTL+G G
Sbjct: 445 IGLVSQEPLLFMTSIKDNIIYGKEDATLEEIKRAAELANAANFIDKLPNGYDTLVGQRGT 504
Query: 2286 QLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRL 2107
LSGGQKQR+AIAR +++DPK+LLLDEATSALD +SE IVQ ALN RTT+++AHRL
Sbjct: 505 LLSGGQKQRIAIARAILKDPKILLLDEATSALDVESERIVQEALNRIMVERTTLVVAHRL 564
Query: 2106 STIREADKIVFFEKGVIVEAGNHEELVR-LGGRYFDLVKAQQFKADPXXXXXXXXXEIDL 1930
ST+R D I +G IVE G H LV+ G Y L++ Q+ + D L
Sbjct: 565 STVRNVDCITVVHQGKIVEQGTHHALVKDPNGAYSQLIRLQETRGDERRKIQDSGVPNSL 624
Query: 1929 DDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKR-------SXXXXXXXXXXXXXXX 1771
+ R + DSF S R
Sbjct: 625 SKSTSLSI---------------RRSMTKDSFGNSNRYSFKNPLGLSVELHEDEITGEQN 669
Query: 1770 XXXXEDGQI--TAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFV 1597
+G+ A +F K ++ LG + A + G+ P ++ V + F
Sbjct: 670 KDDLSNGKTLQKAPIGRLFYLNKPEVPFLLLGAIAASVHGVIFPLFGILMSGVIKAFYEP 729
Query: 1596 PYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDAS 1417
P ++ + + +G + + A +LF + L R R SF+N+++Q+ +
Sbjct: 730 P--DKLRKDSSFWALISVVLGFASFIAIPAEYLLFGIAGGKLIERVRTLSFQNIVHQEVA 787
Query: 1416 YFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXX 1237
+FDNP+++ G L TRL+ DA N++ +V + + W+
Sbjct: 788 WFDNPSNSSGALGTRLSVDALNVRRLVGDNLGLIVQSTAALITGFVIAFTADWRLALIIT 847
Query: 1236 -XXXXXLAFVMIGLAYKISLMNVEQIQNDDAGRIAIEIIENVKTIQLLTRCELFFDHYQT 1060
A + + + +DA ++A + + +++TI + Y
Sbjct: 848 CVIPLVGAQGYAQVKFLKGFSEEAKEMYEDASQVATDAVGSIRTIASFCAEKRVVTTYNK 907
Query: 1059 SSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMM 880
+ ++ ++ G++ + + + +Y + VG + + QG + D FK A++
Sbjct: 908 KCEALRKQGIRSGIVGGLGFGFSFLVLYLTYALCFYVGAQFVRQGKTTFADVFKVFFALV 967
Query: 879 LGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPR------TGDLMEGDRPEIRGNILFE 718
L AV V ++ KA+ +A +F+I+ RK + G ++E + G+I F
Sbjct: 968 LAAVGVSQASALASNATKARDSAISVFSILDRKSKIDTSNDEGLVLE----NVTGDIHFS 1023
Query: 717 NVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDG 538
NV F YP RP I +T+ALVG SGSGKST I +LERFYD G + +DG
Sbjct: 1024 NVSFKYPSRPDVQIFSDFTLHIPSRKTIALVGESGSGKSTIIALLERFYDPDSGIISVDG 1083
Query: 537 QDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGLK-DVPLEKINQALELANANRFLA 361
+I+ L + LR QM LVGQEP LF TIR N+ G +V E++ + ANA+ F++
Sbjct: 1084 VEIKSLRISWLRDQMGLVGQEPVLFNDTIRANITYGKHGEVTEEEVTAVAKAANAHEFIS 1143
Query: 360 NLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALD 181
+LP G DT VGEKG QLSGGQKQR+AIARA+++DPKILLLDEATSALD+ESER VQ+ALD
Sbjct: 1144 SLPQGYDTLVGEKGVQLSGGQKQRVAIARAIIKDPKILLLDEATSALDAESERIVQDALD 1203
Query: 180 RAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQK-GRYYKLIK 22
R RT I +AHRLS+I+ +D+I + +GK+ E G H LM K G Y L++
Sbjct: 1204 RVMVSRTTIVVAHRLSTIKGADMIAVLKEGKIAEKGKHEALMGIKDGVYASLVE 1257
Score = 356 bits (914), Expect = 2e-96
Identities = 222/604 (36%), Positives = 330/604 (53%), Gaps = 14/604 (2%)
Frame = -1
Query: 3762 RGDIAN-QQLEAQPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNAL 3586
+ D++N + L+ P+ G Y K + L +G I A + GV P+ ++ V A
Sbjct: 670 KDDLSNGKTLQKAPI---GRLFYLNKPEVPFLLLGAIAASVHGVIFPLFGILMSGVIKAF 726
Query: 3585 LVYPPTSKQFRNKAN-ENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVL 3409
Y P K ++ + + + LG FI+I +Y+ F +++ ++R +++
Sbjct: 727 --YEPPDKLRKDSSFWALISVVLGFASFIAIP--AEYLLFGIAGGKLIERVRTLSFQNIV 782
Query: 3408 RQNAGWFDK--NHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRL 3235
Q WFD N SG + T+L+ +R +GD LG++++ A LI V+A+ +WRL
Sbjct: 783 HQEVAWFDNPSNSSGALGTRLSVDALNVRRLVGDNLGLIVQSTAALITGFVIAFTADWRL 842
Query: 3234 ASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGK--------AGSIAEESLMGVRTVQA 3079
A ++ V P L +K L G + A +A +++ +RT+ +
Sbjct: 843 ALIITCVIP--------LVGAQGYAQVKFLKGFSEEAKEMYEDASQVATDAVGSIRTIAS 894
Query: 3078 FNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGII 2899
F ++ +V Y + E RK + GA ++ G
Sbjct: 895 FCAEKRVVTTYNKKCEALRKQGIRSGIVGGLGFGFSFLVLYLTYALCFYVGAQFVRQGK- 953
Query: 2898 TTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRL 2719
TT DVF V +++L A + S AR SA S++ +DR KID + G L
Sbjct: 954 TTFADVFKVFFALVLAAVGVSQASALASNATKARDSAISVFSILDRKSKIDTSNDEGLVL 1013
Query: 2718 QNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYE 2539
+NV G + F NV F+YPSR D +I + L + ++ALVG SG GKST + LL R Y+
Sbjct: 1014 ENVTGDIHFSNVSFKYPSRPDVQIFSDFTLHIPSRKTIALVGESGSGKSTIIALLERFYD 1073
Query: 2538 PEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGS-TRETMIEVC 2362
P++G +++DG +++ L I WLR+ +G+V QEP+LFNDTI N+ G G T E + V
Sbjct: 1074 PDSGIISVDGVEIKSLRISWLRDQMGLVGQEPVLFNDTIRANITYGKHGEVTEEEVTAVA 1133
Query: 2361 KMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQ 2182
K ANAH+FI +P+GYDTL+G+ GVQLSGGQKQRVAIAR +I+DPK+LLLDEATSALDA+
Sbjct: 1134 KAANAHEFISSLPQGYDTLVGEKGVQLSGGQKQRVAIARAIIKDPKILLLDEATSALDAE 1193
Query: 2181 SESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRL-GGRYF 2005
SE IVQ AL+ RTTI++AHRLSTI+ AD I ++G I E G HE L+ + G Y
Sbjct: 1194 SERIVQDALDRVMVSRTTIVVAHRLSTIKGADMIAVLKEGKIAEKGKHEALMGIKDGVYA 1253
Query: 2004 DLVK 1993
LV+
Sbjct: 1254 SLVE 1257
Score = 280 bits (715), Expect = 3e-73
Identities = 182/570 (31%), Positives = 296/570 (51%), Gaps = 8/570 (1%)
Frame = -1
Query: 1698 LYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWF 1519
L M +G++ A+ G+ P ++++FG V F ++ + V+ F +G+G
Sbjct: 43 LLMVVGSLGAVGNGVSEPLISVLFGDVINSFG-ESTTSTVLRAVTKVVLNFIYLGIGTAV 101
Query: 1518 SQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAV 1339
+ + + E S R R +++L QD ++FD G+ ++R++SD I+
Sbjct: 102 ASFLQVACWTMAGERQSARIRSLYLKSVLRQDIAFFDTEM-TTGEAVSRMSSDTVIIQDA 160
Query: 1338 VDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQ 1159
+ + ++ W +A A ++ ++ +++
Sbjct: 161 LGEKAGKLVQLTSAFFGGFIIAFTKGWLLTLVMLTSLPLVAIAGAVSAQMLTRVSSKRLT 220
Query: 1158 N-DDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSF 982
+ DA + I +++T+ + + Y K R+ +++G++
Sbjct: 221 SYSDAANTVEQTIGSIRTVVSFNGEKKAIEMYNKFIKSAYRTVVEEGLVNGFGMGSVFCI 280
Query: 981 MYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGML 802
++ + G ++I + + A++ GA ++ N+ + ++AA L
Sbjct: 281 LFSSYGLAFWYGGKLIIDKGYTGGKIVTVLFAVLNGATSLGNATPSISAIAEGQSAAYRL 340
Query: 801 FNIIYRKPR------TGDLMEGDRPEIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQ 640
F I RKP +G +ME I+G + ++V F YP R Q I+ GL G
Sbjct: 341 FETIERKPEIDSDDTSGMIMEN----IKGYVELKDVYFRYPARLGQLILDGLSLQVASGT 396
Query: 639 TVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFA 460
T+A+VG SGSGKST I ++ERFYD G + IDG +I+ L+L +R ++ LV QEP LF
Sbjct: 397 TMAIVGESGSGKSTVISLVERFYDPQAGEVLIDGVNIKNLNLDWIRGKIGLVSQEPLLFM 456
Query: 459 GTIRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAI 280
+I++N+ G +D LE+I +A ELANA F+ LP G DT VG++G LSGGQKQRIAI
Sbjct: 457 TSIKDNIIYGKEDATLEEIKRAAELANAANFIDKLPNGYDTLVGQRGTLLSGGQKQRIAI 516
Query: 279 ARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYI 100
ARA+++DPKILLLDEATSALD ESER VQEAL+R RT + +AHRLS+++N D I +
Sbjct: 517 ARAILKDPKILLLDEATSALDVESERIVQEALNRIMVERTTLVVAHRLSTVRNVDCITVV 576
Query: 99 DKGKVQEAGNHTQLMHQ-KGRYYKLIKKQD 13
+GK+ E G H L+ G Y +LI+ Q+
Sbjct: 577 HQGKIVEQGTHHALVKDPNGAYSQLIRLQE 606
>gi|50546639|ref|XP_500789.1| hypothetical protein [Yarrowia
lipolytica]
gi|49646655|emb|CAG83040.1| unnamed protein product [Yarrowia
lipolytica CLIB99]
Length = 1304
Score = 668 bits (1724), Expect = 0.0
Identities = 428/1276 (33%), Positives = 661/1276 (51%), Gaps = 27/1276 (2%)
Frame = -1
Query: 3756 DIANQQLEAQP--VSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNAL- 3586
DI +Q+ V+ LFRY KFD+ L+ +G + A +GV PI ++ G +TN
Sbjct: 58 DILKRQVRTPDTVVTFMTLFRYADKFDFFLIMVGLVMAAAAGVCLPIFTIIFGSMTNEFT 117
Query: 3585 --LVYPPTSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSV 3412
VY + + F+++ N F+ + + T I+ R+ A++R ++ ++
Sbjct: 118 NFFVYGASKEHFQSRINHFALYFVYLAVATFGTTAIKTYITVERGERLTARIRANYLKAI 177
Query: 3411 LRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLA 3232
LRQN G+FDK +G +T ++ I+EGI +KLG+++ A I A+V+ +I + +L
Sbjct: 178 LRQNIGYFDKLGAGEVTNRITSDTNLIQEGISEKLGLIVSAIASFITALVIGFIKQAKLT 237
Query: 3231 SMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVG 3052
+ML + M + + + T L SIAEE+ +R + AF Q MV
Sbjct: 238 GIMLSTVFALALSMGICSTFLVKYTKLALEDDSACSSIAEEAFSSIRNIVAFGSQSRMVE 297
Query: 3051 RYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIV 2872
+Y L + K + G+ L+ G T G+V V
Sbjct: 298 KYNVPLASSLHNYLRKNISLAVMVGCLWSLIYIKYALALWEGSRLVAWGE-TQVGNVTTV 356
Query: 2871 VMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKF 2692
+M++++GA+ LG ++P++ + A S I+ TIDRVP+ID + G+++ ++ G + F
Sbjct: 357 LMALMIGAFELGGVAPNLESVGVAIASGKKIFGTIDRVPEIDTQEE-GEKIPDIKGHIVF 415
Query: 2691 ENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTID 2512
+NV FRYPSR +IL NL V PG +VALVG SG GKST +GLL R Y+P +G +TID
Sbjct: 416 DNVDFRYPSRPKVQILEDFNLEVLPGQTVALVGASGSGKSTLIGLLERFYQPLSGLITID 475
Query: 2511 GTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGST---------RETMIEVCK 2359
G ++ +L+++WLR + +V QEP LFN TI+ N+ G G+ E + C+
Sbjct: 476 GYNLLDLDVKWLRQHISLVSQEPTLFNCTIYENITFGLIGTQWEHADDEKKMELVEHACR 535
Query: 2358 MANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQS 2179
ANA DFI+ + G +T +G+ G+ LSGGQKQR+AIAR +I +P +LLLDEATSALD +S
Sbjct: 536 QANAWDFIQLLTDGINTNVGESGMLLSGGQKQRIAIARAIISNPPILLLDEATSALDTKS 595
Query: 2178 ESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDL 1999
E IVQ AL+ AS+ RTTI+IAHRLSTI+ A K V++ G E++ G L
Sbjct: 596 EGIVQEALDKASENRTTIVIAHRLSTIKNAS------KIVVMSKG---EIIEQGTHAELL 646
Query: 1998 VKAQQFKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKR 1819
K + +D + + + + S + +
Sbjct: 647 AKQGMYYG-----------LVDAQKLTEARPGQKSSSDGEDAPLLIQEDDMKIGKSTTNK 695
Query: 1818 SXXXXXXXXXXXXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPAL 1639
S G + + K + ++++G+ ALI G PAL
Sbjct: 696 SLSSQILANKEKPDRDKHLSIAGMVKL----LAKYNRNERPFLYVGSFAALINGAGYPAL 751
Query: 1638 ALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFAS----VGVGVWFSQLASSVLFAVVSENL 1471
AL+F + F P M H M + ++ VG+ + SE+L
Sbjct: 752 ALLFASAMQAFMVSP---DMYHWMRSEMNKYSGFLFMVGMIELMAYFVQIYCLGWCSEHL 808
Query: 1470 SMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXX 1291
R F +LL D ++ D + G L + L+ DA ++ + A Q+
Sbjct: 809 VRNIRHSVFSHLLRMDVAFHDEDDNTTGSLTSTLSKDAQYVQGLGGATFGQILSSLCTIV 868
Query: 1290 XXXXXXXIYCWQXXXXXXX---XXXXLAFVMIGLAYKISLMNVEQIQNDDAGRIAIEIIE 1120
Y W+ F + ++L + + + A E
Sbjct: 869 IGVIIAICYTWRLGLVCTACVPLIIAAGFFRFWILTHLNLRGKKVYEQ--SASYACEATT 926
Query: 1119 NVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIR 940
+++T+ LTR + ++ Y + Q + + A ++ +QS + + G
Sbjct: 927 SIRTVVTLTREDYVYNDYLHKVESQVADSARANIYSATLFAASQSLNLLISALGFWYGST 986
Query: 939 IIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTG-DL 763
++ G ++ F ++++ G + + + P+ KAKTA + N++ P D
Sbjct: 987 LMKDGIIDTNKFFVAFVSVVFGCQSAGSIFSFTPDMGKAKTATQNIANMLAVLPELDVDS 1046
Query: 762 MEG---DRPEIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNI 592
EG D +RG+I FE+V+F YP RP PI++GL +GQ VALVG SG GKST I
Sbjct: 1047 TEGIILDHDNVRGDISFEDVRFRYPTRPQVPILRGLNLNIKKGQYVALVGSSGCGKSTTI 1106
Query: 591 GMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGL--KDV 418
++ERFYDV GA+++DG DIR +++ R+ ++LV QEP LF+GT+REN+ LG DV
Sbjct: 1107 ALIERFYDVLSGAVKLDGVDIRDININSYRSCISLVQQEPVLFSGTVRENILLGSLRDDV 1166
Query: 417 PLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLD 238
E++ +A E+AN + F+ +LP G DT G KG LSGGQKQR+AIARAL+R+PKILLLD
Sbjct: 1167 TEEEMIEAAEMANIHSFVMSLPDGYDTYCGSKGSLLSGGQKQRVAIARALIRNPKILLLD 1226
Query: 237 EATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQL 58
EATSALDSESE+ VQ ALD+A +GRT I +AHRLS+IQN+D+I ++G+V E+G H +L
Sbjct: 1227 EATSALDSESEKIVQAALDQAAKGRTTIAVAHRLSTIQNADIIYVFEEGRVLESGTHQEL 1286
Query: 57 MHQKGRYYKLIKKQDL 10
+ K +YY+L+K Q L
Sbjct: 1287 LANKSKYYELVKLQAL 1302
Score = 356 bits (913), Expect = 3e-96
Identities = 220/634 (34%), Positives = 341/634 (53%), Gaps = 19/634 (2%)
Frame = -1
Query: 3831 DDDDAPKMYTPSLLE---KILNYALCRGDIANQQLEAQP--VSIPGLFRYGKKF---DYL 3676
D +DAP + ++ N +L +AN++ + +SI G+ + K+ +
Sbjct: 673 DGEDAPLLIQEDDMKIGKSTTNKSLSSQILANKEKPDRDKHLSIAGMVKLLAKYNRNERP 732
Query: 3675 LLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKANENVYIFLGIGIFISI 3496
L++G+ A+I+G P LAL+ A +V P R++ N+ +G+ +
Sbjct: 733 FLYVGSFAALINGAGYPALALLFASAMQAFMVSPDMYHWMRSEMNKYSGFLFMVGMIELM 792
Query: 3495 TNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFDK--NHSGTITTKLNDSMERIREG 3322
F+Q C C ++ +RH +LR + + D+ N +G++T+ L+ + ++
Sbjct: 793 AYFVQIYCLGWCSEHLVRNIRHSVFSHLLRMDVAFHDEDDNTTGSLTSTLSKDAQYVQGL 852
Query: 3321 IGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELI 3142
G G +L ++ +++A Y WRL G+ T C+ + + A + L
Sbjct: 853 GGATFGQILSSLCTIVIGVIIAICYTWRL-----GLVCTACVPLIIAAGFFRFWILTHLN 907
Query: 3141 GVGK-----AGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXX 2977
GK + S A E+ +RTV ++ + Y ++E +
Sbjct: 908 LRGKKVYEQSASYACEATTSIRTVVTLTREDYVYNDYLHKVESQVADSARANIYSATLFA 967
Query: 2976 XXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNAR 2797
G YG+ L+K GII T F+ +S++ G G I + A+
Sbjct: 968 ASQSLNLLISALGFWYGSTLMKDGIIDT-NKFFVAFVSVVFGCQSAGSIFSFTPDMGKAK 1026
Query: 2796 VSAASIYQTIDRVPKIDPYSKAGKRLQ--NVVGRVKFENVHFRYPSRKDAKILNGLNLVV 2623
+ +I + +P++D S G L NV G + FE+V FRYP+R IL GLNL +
Sbjct: 1027 TATQNIANMLAVLPELDVDSTEGIILDHDNVRGDISFEDVRFRYPTRPQVPILRGLNLNI 1086
Query: 2622 EPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEP 2443
+ G VALVG SGCGKST++ L+ R Y+ +G V +DG D+R++NI R+ + +VQQEP
Sbjct: 1087 KKGQYVALVGSSGCGKSTTIALIERFYDVLSGAVKLDGVDIRDININSYRSCISLVQQEP 1146
Query: 2442 ILFNDTIHNNLLIGN--PGSTRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQ 2269
+LF+ T+ N+L+G+ T E MIE +MAN H F+ +P GYDT G G LSGGQ
Sbjct: 1147 VLFSGTVRENILLGSLRDDVTEEEMIEAAEMANIHSFVMSLPDGYDTYCGSKGSLLSGGQ 1206
Query: 2268 KQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIREA 2089
KQRVAIAR LIR+PK+LLLDEATSALD++SE IVQ+AL+ A+KGRTTI +AHRLSTI+ A
Sbjct: 1207 KQRVAIARALIRNPKILLLDEATSALDSESEKIVQAALDQAAKGRTTIAVAHRLSTIQNA 1266
Query: 2088 DKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQ 1987
D I FE+G ++E+G H+EL+ +Y++LVK Q
Sbjct: 1267 DIIYVFEEGRVLESGTHQELLANKSKYYELVKLQ 1300
>gi|22535563|dbj|BAC10738.1| putative multidrug resistance protein 1
homolog [Oryza sativa (japonica cultivar-group)]
gi|27368857|emb|CAD59586.1| MDR-like ABC transporter [Oryza sativa
(japonica cultivar-group)]
Length = 1274
Score = 667 bits (1721), Expect = 0.0
Identities = 410/1257 (32%), Positives = 664/1257 (52%), Gaps = 23/1257 (1%)
Frame = -1
Query: 3723 VSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKA 3544
VS GLFRY D LL+ +GT+ A+ +GVSQP++ ++ G+V NA T+ ++
Sbjct: 37 VSFTGLFRYADGTDLLLMAVGTVAALANGVSQPLMTVIFGQVINAF--GEATNGDVLHRV 94
Query: 3543 NENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFD-KNHSGT 3367
N+ V F+ +GI ++ +F+Q C+ R ++R ++ SVLRQ+ +FD + +G
Sbjct: 95 NQAVLNFVYLGIATAVVSFLQVACWTMTGERQATRIRSLYLKSVLRQDIAFFDVEMTTGQ 154
Query: 3366 ITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMS 3187
I ++++ +++ IG+K+G L+ A VVA++ W L+ +ML P I
Sbjct: 155 IVSRMSGDTVLVQDAIGEKVGKFLQLVATFAGGFVVAFVKGWLLSLVMLACIPPVVIAGG 214
Query: 3186 LLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVW 3007
+++ + + K A ++ E+++ ++TV +FNG+++ V Y + K K AV
Sbjct: 215 AVSKMLAKISSKGQASYSDAANVVEQTIGAIKTVVSFNGEKQAVASYNKLINKAYKAAVE 274
Query: 3006 KXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLIS 2827
+ G + YG L+ V + GD+ ++ +++ GA LG +
Sbjct: 275 EGLTNGFGMGSVFFIFFSSYGLAIWYGGKLV-VSKGYSGGDIINILFAVMTGAMSLGNAT 333
Query: 2826 PHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKI 2647
P M + +A +++TI R P+IDP GK+L+++ G V+ ++V+F YP+R + I
Sbjct: 334 PCMAAFAEGQSAAYRLFKTIKRKPQIDPDDITGKQLEDIRGDVELKDVYFSYPARPEQLI 393
Query: 2646 LNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNT 2467
+G +L V GT++A+VG SG GKST + L+ R Y+P+AG V IDG +++ L + W+R
Sbjct: 394 FDGFSLHVSSGTTMAIVGESGSGKSTVISLVERFYDPQAGEVLIDGINIKSLRLNWIRGK 453
Query: 2466 VGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGV 2287
+G+V QEP+LF +I +N+ G +T E + ++ANA +FI+K+P GYDT++G G
Sbjct: 454 IGLVSQEPLLFMTSIKDNITYGKEDATIEEIRRAAELANAANFIDKLPDGYDTMVGQRGA 513
Query: 2286 QLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRL 2107
QLSGGQKQR+AIAR ++++PK+LLLDEATSALD +SE IVQ ALN RTT+++AHRL
Sbjct: 514 QLSGGQKQRIAIARAILKNPKILLLDEATSALDVESERIVQEALNRIMVDRTTLVVAHRL 573
Query: 2106 STIREADKIVFFEKGVIVEAGNHEELV-RLGGRYFDLVKAQQFKADPXXXXXXXXXEIDL 1930
+T+R AD I ++G IVE G H+ELV G Y L++ Q+
Sbjct: 574 TTVRNADCISVVQQGKIVEQGPHDELVMNPNGVYSQLIRLQETHE--------------- 618
Query: 1929 DDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXXXXXXXXXXXXXXXEDG 1750
++ S +F+R S + + + S+ S G
Sbjct: 619 EEEKKLDHHISDSRSKSRSLSFKRSISRDSAGNSSRHSLALPFGLPGSVELLEGNDSTVG 678
Query: 1749 QIT--AGYLDIFKNA---------KGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFT 1603
+ T G ++ + A K + L T+ A + G+ P ++ + T
Sbjct: 679 EQTEQGGDGEVQQKAPIGRLARLNKPEVPILLLATLAAGVHGVLFPMFGVMISNAIK--T 736
Query: 1602 FVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQD 1423
F ++ + + +G+ S +F + L R R SFR++++Q+
Sbjct: 737 FFEPADKLKKDASFWGLMCVVLGIISIISIPVEYFMFGIAGGKLVERVRALSFRSIIHQE 796
Query: 1422 ASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXX 1243
++FD+P ++ G L RL+ DA N++ +V + I W+
Sbjct: 797 VAWFDDPRNSSGALGARLSVDALNVRRLVGDNLALAVQVVSTLITGIVIAMIADWK---- 852
Query: 1242 XXXXXXXLAFVMIGLAYKISLMNVEQIQND------DAGRIAIEIIENVKTIQLLTRCEL 1081
++GL + ++ D DA ++A + + +++T+ +
Sbjct: 853 -LTLIILCVIPLVGLQGYAQVKFLKGFSEDAKMLYEDASQVATDAVSSIRTVASFCSEKR 911
Query: 1080 FFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTF 901
Y + K ++ GM+ + + + +Y + VG + + + D F
Sbjct: 912 VMTMYDNKCEASKNQGVRTGMVGGLGFGFSFLMLYLTYGLCFYVGAQFVRHNKTTFGDVF 971
Query: 900 KGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLMEGDR--PEIRGNI 727
K A++L + + ++ + KAK +A +F ++ RK + + R ++GNI
Sbjct: 972 KVFFALVLATIGISQTSAMASDSTKAKDSAISIFALLDRKSQIDSSSDEGRTLANVKGNI 1031
Query: 726 LFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALR 547
F +V F YP RP I G+TVALVG SGSGKST I +LERFY+ G +
Sbjct: 1032 DFRHVSFKYPTRPDVQIFSDFTLHIPSGKTVALVGESGSGKSTAIALLERFYNPESGTIL 1091
Query: 546 IDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGLK-DVPLEKINQALELANANR 370
+D +I+ L + LR QM LVGQEP LF TIR N+ G DV E++ +A + +NA+
Sbjct: 1092 LDEVEIKNLKVNWLRDQMGLVGQEPVLFNDTIRANIAYGKHGDVTEEELIKAAKASNAHE 1151
Query: 369 FLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQE 190
F+++LP G DT VGE+G QLSGGQKQR+AIARA+++DPKILLLDEATSALD+ESER VQ+
Sbjct: 1152 FISSLPQGYDTTVGERGVQLSGGQKQRVAIARAILKDPKILLLDEATSALDAESERIVQD 1211
Query: 189 ALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQK-GRYYKLIK 22
ALD GRT I +AHRLS+I+ +D+I + G + E G H LM+ K G Y L++
Sbjct: 1212 ALDNVMVGRTTIIVAHRLSTIKGADIIAVLKDGAIAEKGRHEALMNIKDGVYASLVE 1268
Score = 304 bits (779), Expect = 1e-80
Identities = 196/583 (33%), Positives = 309/583 (52%), Gaps = 9/583 (1%)
Frame = -1
Query: 1734 YLDIFKNAKG-NYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMA 1558
+ +F+ A G + L M +GTV AL G+ P + +IFG V F G ++HR+ A
Sbjct: 39 FTGLFRYADGTDLLLMAVGTVAALANGVSQPLMTVIFGQVINAFGEAT-NGDVLHRVNQA 97
Query: 1557 VIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLI 1378
V+ F +G+ + + E + R R +++L QD ++FD G+++
Sbjct: 98 VLNFVYLGIATAVVSFLQVACWTMTGERQATRIRSLYLKSVLRQDIAFFDVEM-TTGQIV 156
Query: 1377 TRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGL 1198
+R++ D ++ + ++ + + W V+ G
Sbjct: 157 SRMSGDTVLVQDAIGEKVGKFLQLVATFAGGFVVAFVKGW--LLSLVMLACIPPVVIAGG 214
Query: 1197 AYKISLMNVE---QIQNDDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELK 1027
A L + Q DA + + I +KT+ + Y + ++ ++
Sbjct: 215 AVSKMLAKISSKGQASYSDAANVVEQTIGAIKTVVSFNGEKQAVASYNKLINKAYKAAVE 274
Query: 1026 KGMIEAINYSLTQSFMYFMMCFTYAV--GIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNS 853
+G+ + + F F + A+ G +++ S D + A+M GA+++ N+
Sbjct: 275 EGLTNG--FGMGSVFFIFFSSYGLAIWYGGKLVVSKGYSGGDIINILFAVMTGAMSLGNA 332
Query: 852 AQYFPEFVKAKTAAGMLFNIIYRKPRTG--DLMEGDRPEIRGNILFENVKFSYPQRPLQP 679
F + ++AA LF I RKP+ D+ +IRG++ ++V FSYP RP Q
Sbjct: 333 TPCMAAFAEGQSAAYRLFKTIKRKPQIDPDDITGKQLEDIRGDVELKDVYFSYPARPEQL 392
Query: 678 IMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRT 499
I G G T+A+VG SGSGKST I ++ERFYD G + IDG +I+ L L +R
Sbjct: 393 IFDGFSLHVSSGTTMAIVGESGSGKSTVISLVERFYDPQAGEVLIDGINIKSLRLNWIRG 452
Query: 498 QMALVGQEPRLFAGTIRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGEKG 319
++ LV QEP LF +I++N+ G +D +E+I +A ELANA F+ LP G DT VG++G
Sbjct: 453 KIGLVSQEPLLFMTSIKDNITYGKEDATIEEIRRAAELANAANFIDKLPDGYDTMVGQRG 512
Query: 318 GQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHR 139
QLSGGQKQRIAIARA++++PKILLLDEATSALD ESER VQEAL+R RT + +AHR
Sbjct: 513 AQLSGGQKQRIAIARAILKNPKILLLDEATSALDVESERIVQEALNRIMVDRTTLVVAHR 572
Query: 138 LSSIQNSDLIVYIDKGKVQEAGNHTQL-MHQKGRYYKLIKKQD 13
L++++N+D I + +GK+ E G H +L M+ G Y +LI+ Q+
Sbjct: 573 LTTVRNADCISVVQQGKIVEQGPHDELVMNPNGVYSQLIRLQE 615
>gi|266518|sp|Q00449|MDR4_DROME Multidrug resistance protein homolog
49 (P-glycoprotein 49)
gi|103251|pir||A41249 multidrug resistance protein homolog Mdr49 -
fruit fly (Drosophila melanogaster)
gi|157871|gb|AAA28679.1| P glycoprotein
gi|16198339|gb|AAL14020.1| SD10012p [Drosophila melanogaster]
Length = 1302
Score = 667 bits (1721), Expect = 0.0
Identities = 418/1277 (32%), Positives = 649/1277 (50%), Gaps = 43/1277 (3%)
Frame = -1
Query: 3708 LFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALL------------------ 3583
LFRY + + LL + + A + P ++ G T+ L+
Sbjct: 34 LFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGEFTSLLVDRTVGVGTSSPAFALPMF 93
Query: 3582 ----VYPPTSKQFRNKANENVYIFLGIGIFI-SITNFIQYMCFQHCCTRV----MAQMRH 3430
SK+ N+A + GIG + S+ F+ R+ + ++R
Sbjct: 94 GGGQQLTNASKEENNQAIIDDATAFGIGSLVGSVAMFLLITLAIDLANRIALNQIDRIRK 153
Query: 3429 RFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYI 3250
F+ ++LRQ+ W+D + +K+ + +++++EGIG+K+ +++ + IV A++
Sbjct: 154 LFLEAMLRQDIAWYDTSSGSNFASKMTEDLDKLKEGIGEKIVIVVFLIMTFVIGIVSAFV 213
Query: 3249 YEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNG 3070
Y W+L ++L P S++AR S KEL A ++ EE G+RTV AF+G
Sbjct: 214 YGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEEVFSGIRTVFAFSG 273
Query: 3069 QEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLK-----VG 2905
QE+ R+ L K + YG L+
Sbjct: 274 QEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGVTLILDERDLPD 333
Query: 2904 IITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGK 2725
+ TP + IV+ ++++GA LG SPH+ + A + +++ IDR ++DP + G
Sbjct: 334 RVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMDEKGN 393
Query: 2724 RLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRL 2545
R +N G ++FE + FRYP+R D +IL GL + V PG +VA VG SGCGKST + L+ R
Sbjct: 394 RPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRF 453
Query: 2544 YEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEV 2365
Y+PEAG+V +DG D+R LN+ WLR+ +G+V QEP+LF TI N+ G P +T+ + +
Sbjct: 454 YDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQADIEKA 513
Query: 2364 CKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDA 2185
+ AN HDFI ++PKGYDT +G+ G Q+SGGQKQR+AIAR L+R P+VLLLDEATSALD
Sbjct: 514 ARAANCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDP 573
Query: 2184 QSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYF 2005
SE VQSAL AS+G TT+++AHRLSTI ADKIVF + GV+ E G HEEL+ G Y
Sbjct: 574 TSEKRVQSALELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMERRGLYC 633
Query: 2004 DLVKAQQFKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGS 1825
+LV Q K E SGS
Sbjct: 634 ELVSITQRKEATEADEGAVAGR-----PLQKSQNLSDEETDDDEEDEEEDEEPELQTSGS 688
Query: 1824 KRSXXXXXXXXXXXXXXXXXXXEDGQITA--GYLDIFKNAKGNYLYMFLGTVFALIRGLE 1651
R +D ++ + + + K + ++ +G + +++ G
Sbjct: 689 SRDSGFRASTRRKRRSQRRKKKKDKEVVSKVSFTQLMKLNSPEWRFIVVGGIASVMHGAT 748
Query: 1650 LPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVW--FSQLASSVLFAVVSE 1477
P L FG + F + G + R + I+ VG+G+ + + +F
Sbjct: 749 FPLWGLFFG---DFFGILSDGDDDVVRAEVLKISMIFVGIGLMAGLGNMLQTYMFTTAGV 805
Query: 1476 NLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXX 1297
++ R R ++F ++ QD +YFD+ ++ G L +RLASD N++ AR+ +
Sbjct: 806 KMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASDCSNVQGATGARVGTMLQAVAT 865
Query: 1296 XXXXXXXXXIYCWQXXXXXXXXXXXLAF-VMIGLAYKISLMNVEQIQNDDAGRIAIEIIE 1120
++ WQ + V + + + + ++A ++A+E I
Sbjct: 866 LVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQKAKASIEEASQVAVEAIT 925
Query: 1119 NVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIR 940
N++T+ L D Y + + +K + ++L Q+ + + G
Sbjct: 926 NIRTVNGLCLERQVLDQYVQQIDRVDVACRRKVRFRGLVFALGQAAPFLAYGISMYYGGI 985
Query: 939 IIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYR---KPRTG 769
++ + + +D K A++ G+ + + Y P A +AG L ++ R +P
Sbjct: 986 LVAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNVNDAILSAGRLMDLFKRTSTQPNPP 1045
Query: 768 DLMEGDRPEIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIG 589
+ G+I++ENV F YP R PI++GL T + TVALVGPSGSGKST +
Sbjct: 1046 QSPYNTVEKSEGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQ 1105
Query: 588 MLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG---LKDV 418
+L R+YD G++ + G + L LR+++ LV QEP LF TI EN+ G DV
Sbjct: 1106 LLLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDV 1165
Query: 417 PLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLD 238
+++I +A + +N + F++ LP G DT +G K QLSGGQKQRIAIARALVR+PKIL+LD
Sbjct: 1166 SMQEIIEAAKKSNIHNFISALPQGYDTRLG-KTSQLSGGQKQRIAIARALVRNPKILILD 1224
Query: 237 EATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQL 58
EATSALD ESE+ VQ+ALD AR GRTC+TIAHRL++++N+DLI + +G V E G H +L
Sbjct: 1225 EATSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDEL 1284
Query: 57 MHQKGRYYKLIKKQDLA 7
M Y L Q ++
Sbjct: 1285 MALNKIYANLYLMQQVS 1301
>gi|24653245|ref|NP_523724.2| CG3879-PA [Drosophila melanogaster]
gi|21627300|gb|AAF58437.2| CG3879-PA [Drosophila melanogaster]
Length = 1302
Score = 667 bits (1721), Expect = 0.0
Identities = 418/1277 (32%), Positives = 649/1277 (50%), Gaps = 43/1277 (3%)
Frame = -1
Query: 3708 LFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALL------------------ 3583
LFRY + + LL + + A + P ++ G T+ L+
Sbjct: 34 LFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGEFTSLLVDRTVGVGTSSPAFALPMF 93
Query: 3582 ----VYPPTSKQFRNKANENVYIFLGIGIFI-SITNFIQYMCFQHCCTRV----MAQMRH 3430
SK+ N+A + GIG + S+ F+ R+ + ++R
Sbjct: 94 GGGQQLTNASKEENNQAIIDDATAFGIGSLVGSVAMFLLITLAIDLANRIALNQIDRIRK 153
Query: 3429 RFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYI 3250
F+ ++LRQ+ W+D + +K+ + +++++EGIG+K+ +++ + IV A++
Sbjct: 154 LFLEAMLRQDIAWYDTSSGSNFASKMTEDLDKLKEGIGEKIVIVVFLIMTFVIGIVSAFV 213
Query: 3249 YEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNG 3070
Y W+L ++L P S++AR S KEL A ++ EE G+RTV AF+G
Sbjct: 214 YGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEEVFSGIRTVFAFSG 273
Query: 3069 QEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLK-----VG 2905
QE+ R+ L K + YG L+
Sbjct: 274 QEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGVTLILDERDLPD 333
Query: 2904 IITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGK 2725
+ TP + IV+ ++++GA LG SPH+ + A + +++ IDR ++DP + G
Sbjct: 334 RVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMDEKGN 393
Query: 2724 RLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRL 2545
R +N G ++FE + FRYP+R D +IL GL + V PG +VA VG SGCGKST + L+ R
Sbjct: 394 RPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRF 453
Query: 2544 YEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEV 2365
Y+PEAG+V +DG D+R LN+ WLR+ +G+V QEP+LF TI N+ G P +T+ + +
Sbjct: 454 YDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQADIEKA 513
Query: 2364 CKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDA 2185
+ AN HDFI ++PKGYDT +G+ G Q+SGGQKQR+AIAR L+R P+VLLLDEATSALD
Sbjct: 514 ARAANCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDP 573
Query: 2184 QSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYF 2005
SE VQSAL AS+G TT+++AHRLSTI ADKIVF + GV+ E G HEEL+ G Y
Sbjct: 574 TSEKRVQSALELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMERRGLYC 633
Query: 2004 DLVKAQQFKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGS 1825
+LV Q K E SGS
Sbjct: 634 ELVSITQRKEATEADEGAVAGR-----PLQKSQNLSDEETDDDEEDEEEDEEPELQTSGS 688
Query: 1824 KRSXXXXXXXXXXXXXXXXXXXEDGQITA--GYLDIFKNAKGNYLYMFLGTVFALIRGLE 1651
R +D ++ + + + K + ++ +G + +++ G
Sbjct: 689 SRDSGFRASTRRKRRSQRRKKKKDKEVVSKVSFTQLMKLNSPEWRFIVVGGIASVMHGAT 748
Query: 1650 LPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVW--FSQLASSVLFAVVSE 1477
P L FG + F + G + R + I+ VG+G+ + + +F
Sbjct: 749 FPLWGLFFG---DFFGILSDGDDDVVRAEVLKISMIFVGIGLMAGLGNMLQTYMFTTAGV 805
Query: 1476 NLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXX 1297
++ R R ++F ++ QD +YFD+ ++ G L +RLASD N++ AR+ +
Sbjct: 806 KMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASDCSNVQGATGARVGTMLQAVAT 865
Query: 1296 XXXXXXXXXIYCWQXXXXXXXXXXXLAF-VMIGLAYKISLMNVEQIQNDDAGRIAIEIIE 1120
++ WQ + V + + + + ++A ++A+E I
Sbjct: 866 LVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQKAKASIEEASQVAVEAIT 925
Query: 1119 NVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIR 940
N++T+ L D Y + + +K + ++L Q+ + + G
Sbjct: 926 NIRTVNGLCLERQVLDQYVQQIDRVDIACRRKVRFRGLVFALGQAAPFLAYGISMYYGGI 985
Query: 939 IIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYR---KPRTG 769
++ + + +D K A++ G+ + + Y P A +AG L ++ R +P
Sbjct: 986 LVAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNVNDAILSAGRLMDLFKRTSTQPNPP 1045
Query: 768 DLMEGDRPEIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIG 589
+ G+I++ENV F YP R PI++GL T + TVALVGPSGSGKST +
Sbjct: 1046 QSPYNTVEKSEGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQ 1105
Query: 588 MLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLG---LKDV 418
+L R+YD G++ + G + L LR+++ LV QEP LF TI EN+ G DV
Sbjct: 1106 LLLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDV 1165
Query: 417 PLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLD 238
+++I +A + +N + F++ LP G DT +G K QLSGGQKQRIAIARALVR+PKIL+LD
Sbjct: 1166 SMQEIIEAAKKSNIHNFISALPQGYDTRLG-KTSQLSGGQKQRIAIARALVRNPKILILD 1224
Query: 237 EATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQL 58
EATSALD ESE+ VQ+ALD AR GRTC+TIAHRL++++N+DLI + +G V E G H +L
Sbjct: 1225 EATSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDEL 1284
Query: 57 MHQKGRYYKLIKKQDLA 7
M Y L Q ++
Sbjct: 1285 MALNKIYANLYLMQQVS 1301
>gi|46390486|dbj|BAD15946.1| putative MDR-like ABC transporter [Oryza
sativa (japonica cultivar-group)]
gi|50252693|dbj|BAD28861.1| putative MDR-like ABC transporter [Oryza
sativa (japonica cultivar-group)]
Length = 1285
Score = 666 bits (1719), Expect = 0.0
Identities = 423/1277 (33%), Positives = 657/1277 (51%), Gaps = 44/1277 (3%)
Frame = -1
Query: 3732 AQPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNAL-------LVYP 3574
A+ V + LF + + D L+ +G + A+ +GV+ P LA + G + +A +V+
Sbjct: 25 AKRVPMRRLFTFADRLDAALMAVGGVAAVANGVAMPFLAFLIGELVDAFGAADRAHVVHV 84
Query: 3573 PTSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAG 3394
+ R Y+ +G GI F+Q C+ R A++R ++ ++LRQ+
Sbjct: 85 VSKISLRF-----TYVAIGSGI----AGFLQVSCWMVTGERQAARIRGLYLEAILRQDIT 135
Query: 3393 WFD-KNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLG 3217
+FD + +G +T +++ I++ IG+K+G L+ + + ++A+ W L+ +ML
Sbjct: 136 FFDLETSTGEVTERMSSDTVLIQDAIGEKVGKFLQLLSTFLGGFIIAFARGWLLSLVMLS 195
Query: 3216 VAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAE 3037
P + + ++ ++ + + +AG + E+++ +RTV +F G+ +Y
Sbjct: 196 SIPPVALAAAAMSIAISKLANRSQLAYAEAGKLVEQTIGSIRTVVSFTGERRATDKYNEF 255
Query: 3036 LEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSML 2857
L+ + AV + G + YGA L+ + T G + V+M+++
Sbjct: 256 LKISYRSAVHQGAAMGLGIGSVMFIVFCSYGLAVWYGAKLI-IEKGYTGGYIINVLMAIM 314
Query: 2856 LGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHF 2677
GA LG SP + + +++A ++ TI+R P+ID ++G L+N VG V+F++VHF
Sbjct: 315 SGAMALGQSSPCLNAFASGQIAAYKMFATINREPEIDASDRSGLVLENFVGDVEFKDVHF 374
Query: 2676 RYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVR 2497
YP+R + I G ++ + G ++ALVG SG GKST + L+ R Y+P++G V +DG +++
Sbjct: 375 SYPARPEQLIFTGFSISIPSGMTMALVGESGSGKSTVISLVERFYDPQSGEVLLDGVNMK 434
Query: 2496 ELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKG 2317
LN+ +R +G+V QEPILF TI N+ G ++ E + +ANA FI+K+P G
Sbjct: 435 LLNLSRIRQKIGLVSQEPILFTTTIRENIEYGKKDASEEEIRRAIVLANAAKFIDKLPNG 494
Query: 2316 YDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKG 2137
DT++G+ G QLSGGQKQR+AIAR +++DP++LLLDEATSALDA+SE +VQ ALNN
Sbjct: 495 LDTMVGEHGTQLSGGQKQRIAIARAILKDPRILLLDEATSALDAESEHVVQDALNNIMVN 554
Query: 2136 RTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLG-GRYFDLVKAQQFKA----- 1975
RTTI++AHRLST+R AD I +G +VE G H EL++ G Y+ L++ Q+ A
Sbjct: 555 RTTIIVAHRLSTVRNADTISVLHRGQLVEQGPHAELIKYSNGAYYQLLQLQEVNARRNGT 614
Query: 1974 ---DPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSE------AFRRGNSLNDSFSGSK 1822
DP D+ + S +F R S + S GS+
Sbjct: 615 YELDPNRLSDVANRLSDVANRLSDAANRLSDAGNFVSRHSIRKLSFERSMSRHSSLGGSR 674
Query: 1821 RSXXXXXXXXXXXXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPA 1642
R+ + + K + LG + A G LP
Sbjct: 675 RNSQTYALTEDEIEGCDDTKSGKNVLRR----LLHLHKPETAILLLGCIAASANGAILPV 730
Query: 1641 LALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMR 1462
L+ F P+ ++ + +GV F LF + L R
Sbjct: 731 FGLLLSSAINAFYEPPH--KLRKDSVFWAEIYVILGVVSIFIIPVQHTLFNMAGGKLIER 788
Query: 1461 FRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXX 1282
R SF ++YQD +FD+P ++ G + RL++DA ++K++ + +
Sbjct: 789 IRALSFSRVVYQDIGWFDDPLNSSGAIGARLSADAASVKSIAGDVLSLIVQSISTALVGI 848
Query: 1281 XXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQ------------NDDAGRI 1138
I W+ LAF+++ + + Q + + A I
Sbjct: 849 VIAMIANWK-----------LAFIVLCFVPCVFAQSYAQSRLMRGFGADAKEMYEQASTI 897
Query: 1137 AIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFT 958
A + I N++T+ E + Y+ K + +++G I + Y + + ++ +
Sbjct: 898 ASDAISNIRTVTSFCVGEKIIESYRNKCKGPVKKGVRQGAISGVGYGFSFALLFCFYAVS 957
Query: 957 YAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKP 778
+ VG R ++ G + FK A+ + AV V S+ +F K + AA +F II RK
Sbjct: 958 FYVGARFVHNGTADVGEVFKVFFALTMMAVGVSQSSSLARDFSKVQDAAASIFKIIDRKS 1017
Query: 777 R-TGDLMEGDRPE-IRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQ------TVALVG 622
+ +G PE I GNI F++V F YP R I L G+ TVALVG
Sbjct: 1018 KIDASSDDGMAPEKIEGNIEFQHVSFKYPARTDVQIFTNLCLRIPSGKVHVVLMTVALVG 1077
Query: 621 PSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIREN 442
SGSGKST + +LERFYD GA+ +DG D++ L L LR Q+ LVGQEP LF GTIR N
Sbjct: 1078 ESGSGKSTVVALLERFYDPDSGAIFLDGMDLKTLKLTWLRQQIGLVGQEPVLFNGTIRAN 1137
Query: 441 VCLGLKD-VPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALV 265
+ G +D V E+I E ANA+RF+++LP G DT VGE+G QLSGGQKQRIAIARA++
Sbjct: 1138 IAYGKQDQVSEEEIVAVAEAANAHRFISSLPHGYDTSVGERGVQLSGGQKQRIAIARAIL 1197
Query: 264 RDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKV 85
+DPK+LLLDEATSALDSESER VQEALDR GRT + +AHRLS+I +D I I G V
Sbjct: 1198 KDPKVLLLDEATSALDSESERIVQEALDRVMVGRTTVIVAHRLSTITGADKIAVIKNGVV 1257
Query: 84 QEAGNHTQLMHQKGRYY 34
E G H +L+ G Y
Sbjct: 1258 AEEGRHGRLLRLPGGAY 1274
Score = 328 bits (842), Expect = 5e-88
Identities = 207/577 (35%), Positives = 309/577 (52%), Gaps = 14/577 (2%)
Frame = -1
Query: 3675 LLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKAN-ENVYIFLGIGIFIS 3499
+L +G I A +G P+ L+ NA Y P K ++ +Y+ LG+
Sbjct: 713 ILLLGCIAASANGAILPVFGLLLSSAINAF--YEPPHKLRKDSVFWAEIYVILGVVSIFI 770
Query: 3498 ITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFDK--NHSGTITTKLNDSMERIRE 3325
I +Q+ F +++ ++R V+ Q+ GWFD N SG I +L+ ++
Sbjct: 771 IP--VQHTLFNMAGGKLIERIRALSFSRVVYQDIGWFDDPLNSSGAIGARLSADAASVKS 828
Query: 3324 GIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMT---STTI 3154
GD L ++++ + + IV+A I W+LA ++L P C S ++
Sbjct: 829 IAGDVLSLIVQSISTALVGIVIAMIANWKLAFIVLCFVP-CVFAQSYAQSRLMRGFGADA 887
Query: 3153 KELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXX 2974
KE+ +A +IA +++ +RTV +F E+++ Y + + K V +
Sbjct: 888 KEMYE--QASTIASDAISNIRTVTSFCVGEKIIESYRNKCKGPVKKGVRQGAISGVGYGF 945
Query: 2973 XXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARV 2794
GA + G G+VF V ++ + A + S +
Sbjct: 946 SFALLFCFYAVSFYVGARFVHNGTADV-GEVFKVFFALTMMAVGVSQSSSLARDFSKVQD 1004
Query: 2793 SAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPG 2614
+AASI++ IDR KID S G + + G ++F++V F+YP+R D +I L L + G
Sbjct: 1005 AAASIFKIIDRKSKIDASSDDGMAPEKIEGNIEFQHVSFKYPARTDVQIFTNLCLRIPSG 1064
Query: 2613 T------SVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQ 2452
+VALVG SG GKST V LL R Y+P++G + +DG D++ L + WLR +G+V
Sbjct: 1065 KVHVVLMTVALVGESGSGKSTVVALLERFYDPDSGAIFLDGMDLKTLKLTWLRQQIGLVG 1124
Query: 2451 QEPILFNDTIHNNLLIGNPGS-TRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSG 2275
QEP+LFN TI N+ G + E ++ V + ANAH FI +P GYDT +G+ GVQLSG
Sbjct: 1125 QEPVLFNGTIRANIAYGKQDQVSEEEIVAVAEAANAHRFISSLPHGYDTSVGERGVQLSG 1184
Query: 2274 GQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIR 2095
GQKQR+AIAR +++DPKVLLLDEATSALD++SE IVQ AL+ GRTT+++AHRLSTI
Sbjct: 1185 GQKQRIAIARAILKDPKVLLLDEATSALDSESERIVQEALDRVMVGRTTVIVAHRLSTIT 1244
Query: 2094 EADKIVFFEKGVIVEAGNHEELVRL-GGRYFDLVKAQ 1987
ADKI + GV+ E G H L+RL GG Y LV Q
Sbjct: 1245 GADKIAVIKNGVVAEEGRHGRLLRLPGGAYASLVALQ 1281
Score = 293 bits (751), Expect = 2e-77
Identities = 195/572 (34%), Positives = 306/572 (53%), Gaps = 11/572 (1%)
Frame = -1
Query: 1692 MFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQ 1513
M +G V A+ G+ +P LA + G + + F ++H ++ + F V +G +
Sbjct: 45 MAVGGVAAVANGVAMPFLAFLIGELVDAFGAADRA-HVVHVVSKISLRFTYVAIGSGIAG 103
Query: 1512 LASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVD 1333
+ V E + R R +L QD ++FD + G++ R++SD I+ +
Sbjct: 104 FLQVSCWMVTGERQAARIRGLYLEAILRQDITFFDLET-STGEVTERMSSDTVLIQDAIG 162
Query: 1332 ARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKIS-LMNVEQIQN 1156
++ + W +A ++ IS L N Q+
Sbjct: 163 EKVGKFLQLLSTFLGGFIIAFARGWLLSLVMLSSIPPVALAAAAMSIAISKLANRSQLAY 222
Query: 1155 DDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMY 976
+AG++ + I +++T+ T D Y K RS + +G + S M+
Sbjct: 223 AEAGKLVEQTIGSIRTVVSFTGERRATDKYNEFLKISYRSAVHQGAAMGLGIG---SVMF 279
Query: 975 FMMC-FTYAV--GIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGM 805
+ C + AV G ++I + + ++A+M GA+A+ S+ F + AA
Sbjct: 280 IVFCSYGLAVWYGAKLIIEKGYTGGYIINVLMAIMSGAMALGQSSPCLNAFASGQIAAYK 339
Query: 804 LFNIIYRKP------RTGDLMEGDRPEIRGNILFENVKFSYPQRPLQPIMKGLQWTALRG 643
+F I R+P R+G ++E G++ F++V FSYP RP Q I G + G
Sbjct: 340 MFATINREPEIDASDRSGLVLEN----FVGDVEFKDVHFSYPARPEQLIFTGFSISIPSG 395
Query: 642 QTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLF 463
T+ALVG SGSGKST I ++ERFYD G + +DG +++ L+L +R ++ LV QEP LF
Sbjct: 396 MTMALVGESGSGKSTVISLVERFYDPQSGEVLLDGVNMKLLNLSRIRQKIGLVSQEPILF 455
Query: 462 AGTIRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIA 283
TIREN+ G KD E+I +A+ LANA +F+ LP G+DT VGE G QLSGGQKQRIA
Sbjct: 456 TTTIRENIEYGKKDASEEEIRRAIVLANAAKFIDKLPNGLDTMVGEHGTQLSGGQKQRIA 515
Query: 282 IARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVY 103
IARA+++DP+ILLLDEATSALD+ESE VQ+AL+ RT I +AHRLS+++N+D I
Sbjct: 516 IARAILKDPRILLLDEATSALDAESEHVVQDALNNIMVNRTTIIVAHRLSTVRNADTISV 575
Query: 102 IDKGKVQEAGNHTQLM-HQKGRYYKLIKKQDL 10
+ +G++ E G H +L+ + G YY+L++ Q++
Sbjct: 576 LHRGQLVEQGPHAELIKYSNGAYYQLLQLQEV 607
>gi|17569907|ref|NP_509813.1| P-GlycoProtein related (pgp-6)
[Caenorhabditis elegans]
gi|6425208|emb|CAA94220.2| Hypothetical protein T21E8.1
[Caenorhabditis elegans]
Length = 1225
Score = 665 bits (1715), Expect = 0.0
Identities = 413/1257 (32%), Positives = 655/1257 (51%), Gaps = 22/1257 (1%)
Frame = -1
Query: 3708 LFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYP--------------P 3571
+F+ F+ L +G + ++++G QP ++ G V+ L+
Sbjct: 31 VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEK 90
Query: 3570 TSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGW 3391
+++ N+ V+ F G I +Q+ ++ ++R +++ +L+++A +
Sbjct: 91 AYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQY 150
Query: 3390 FDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVA 3211
FD +G ++T LND++ER RE +K+ +++ +A+ +WRLAS + +
Sbjct: 151 FDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFS 210
Query: 3210 PTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELE 3031
+ + + TT K+ AGSIA ++L +TV + NGQ+ + RY EL+
Sbjct: 211 LGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELK 270
Query: 3030 KGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLG 2851
G K+ + + + GA ++ G + T +VV
Sbjct: 271 AGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYSGTLETA----VVVRD---- 322
Query: 2850 AYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRY 2671
D V + D + V G + F+NV F Y
Sbjct: 323 ----------------------------DNVIEKDETDYDVE--VEVNGNISFKNVKFSY 352
Query: 2670 PSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVREL 2491
P+R DA++L G++ V+ G +ALVG SG GKST V LL Y ++GN+ IDG D+ ++
Sbjct: 353 PTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDM 412
Query: 2490 NIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYD 2311
NI+ LR +G+V QEP+LFN TI N+ GNP + + + ANA+DF+ PKG
Sbjct: 413 NIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIK 472
Query: 2310 TLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRT 2131
T++G+ G QLSGGQKQR+AIARTL+R+PK+LLLDEATSALD +SE +VQ AL NAS+GRT
Sbjct: 473 TIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRT 532
Query: 2130 TIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKADPXXXXXX 1951
TI++AHRLSTIR A KI+ +KG IVE GNH+EL+ G Y DLV+AQ ++
Sbjct: 533 TIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLESHDDHEELP 592
Query: 1950 XXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXXXXXXXXXXX 1771
L S S++ + +
Sbjct: 593 PLAARQLSQEL----------------------SPLHSYAIQRSTSNDAGVHDDDMERIL 630
Query: 1770 XXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPY 1591
++G + +I K + +Y ++F+ + I+G+ P LA + +EGF +
Sbjct: 631 DELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMI-- 688
Query: 1590 GGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYF 1411
G M++ + ++F + V + F VSE LS R R++SF ++L +++
Sbjct: 689 GEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFY 748
Query: 1410 DNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXX 1231
D+P H+ +L RL +D+ N+KA VD R+ V +YCW+
Sbjct: 749 DDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMF 808
Query: 1230 XXXLAFVMIGLA-YKISLMNVEQIQND-----DAGRIAIEIIENVKTIQLLTRCELFFDH 1069
F ++ LA Y IQ D ++ R AIE +ENV+T++ L +
Sbjct: 809 -----FPLLYLAEYCYEAATETAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSL 863
Query: 1068 YQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGII 889
++ +S K+ +I+ L+ S F+ ++ G + + + + DT+ ++
Sbjct: 864 ISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLM 923
Query: 888 AMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNII-YRKPRTGDLMEGDRPEIRGNILFENV 712
+ + A ++A Y P++ KA AAG++F++ Y +G + +G I+ ENV
Sbjct: 924 TLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGENV 983
Query: 711 KFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQD 532
+F Y QRP + I+ G+ G+T+ALVGPSG GKST I +LERFY G ++ID ++
Sbjct: 984 QFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSEN 1043
Query: 531 IRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGL-KDVPLEKINQALELANANRFLANL 355
+ ++L HLR+ +ALV QEP LF +IREN+ GL + VP ++ +AL+ ANA F+
Sbjct: 1044 VEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQF 1103
Query: 354 PAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRA 175
P G+DT VGE+G QLSGGQKQRIAIARA++R+PK+LLLDEATSALDS+SE+ VQ ALD A
Sbjct: 1104 PQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTA 1163
Query: 174 REGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQDLAV 4
E + + +AHRLS++ N+D I + GKV E G H +L+ ++ Y++L++KQ + V
Sbjct: 1164 SERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQV 1220
Score = 303 bits (777), Expect = 2e-80
Identities = 195/575 (33%), Positives = 299/575 (51%), Gaps = 4/575 (0%)
Frame = -1
Query: 3684 DYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKANENVYIFLGIGIF 3505
DY LFI + I GVS PILA + R + + + F+ + +F
Sbjct: 653 DYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYYSHLW---ALSFMFLAVF 709
Query: 3504 ISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFDK-NHSGT-ITTKLNDSMERI 3331
+T + QY F ++ ++R + +L ++D NHS T ++ +LN +
Sbjct: 710 RPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNV 769
Query: 3330 REGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIK 3151
+ + D+LG ++ + AI A +Y W++ +L P + T T I+
Sbjct: 770 KAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPLLYLA-EYCYEAATETAIQ 828
Query: 3150 E-LIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXX 2974
E I + A E+L VRTV+A N +++++ L+K K +
Sbjct: 829 EDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGL 888
Query: 2973 XXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARV 2794
+G YL + P D ++V+M++ + A G + ++ A V
Sbjct: 889 SLSCFLFVYSVSFKFGTYLALRKEVA-PMDTYLVLMTLSMTANMAGSAAAYLPDYKKA-V 946
Query: 2793 SAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPG 2614
AA + + P P+S + + G + ENV F Y R D ILNG+NL V+PG
Sbjct: 947 HAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPG 1006
Query: 2613 TSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILF 2434
++ALVG SGCGKST + LL R Y G V ID +V ++N+ LR+ + +V QEP LF
Sbjct: 1007 KTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLF 1066
Query: 2433 NDTIHNNLLIGNPGSTRETMIE-VCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRV 2257
N +I NLL G S + +E + ANA +F+ + P+G DTL+G+ G QLSGGQKQR+
Sbjct: 1067 NCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRI 1126
Query: 2256 AIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIV 2077
AIAR ++R+PKVLLLDEATSALD+ SE +VQ+AL+ AS+ +T+++AHRLST+ AD I
Sbjct: 1127 AIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIA 1186
Query: 2076 FFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKAD 1972
+ G + E G HEEL+R Y+ LV+ Q + +
Sbjct: 1187 VLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQVE 1221
>gi|50260330|gb|EAL22989.1| hypothetical protein CNBA7570
[Cryptococcus neoformans var. neoformans B-3501A]
Length = 1408
Score = 664 bits (1713), Expect = 0.0
Identities = 423/1287 (32%), Positives = 666/1287 (50%), Gaps = 47/1287 (3%)
Frame = -1
Query: 3726 PVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVY---------- 3577
PVS LFR+ + + + +G + A+ +G QP++ L+ GR+T + Y
Sbjct: 138 PVSFFALFRFAAPLEIVAMVLGLVLAVAAGCCQPLMTLIFGRLTTSFTNYAVIVNQISQV 197
Query: 3576 ---PPTSK-------QFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHR 3427
P TS + ++ N + IGI + + ++ + ++R R
Sbjct: 198 GLTPETSAALQAAKDDLKTQSGHNALYLMAIGIAMFLATWLYMFIWNVTGELNSKRIRER 257
Query: 3426 FVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIY 3247
++ +VLRQ +FD +G + T++ ++EG +K+ ++ + + V+A++
Sbjct: 258 YLAAVLRQEIAYFDDLGAGEVATRIQTDCHLVQEGTSEKVALVFQYAGTFVCGFVLAFVR 317
Query: 3246 EWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQ 3067
RLA ++ + P +C ++ M L + KAGS+AEE + +RTVQAF G+
Sbjct: 318 SPRLAGALISILPVIMLCGGIMMTAMAKFGTAALDHIAKAGSLAEEVIASIRTVQAF-GK 376
Query: 3066 EEMVG-RYEAELEK----GRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGI 2902
E+++G ++ +E+ GRK ++++ YG L+ G
Sbjct: 377 EKILGDKFADHIEQSKIVGRKGSIFEGFGLSIMFFAIYAAYALA----FFYGGVLVSQGR 432
Query: 2901 ITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKR 2722
+ G V V MS+L+G++ + +++P + + AR +AA ++ TIDRVP ID S G +
Sbjct: 433 ADS-GIVINVFMSILIGSFSMAMLAPELAAVTKARGAAAKLFATIDRVPTIDSASDEGLK 491
Query: 2721 LQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLY 2542
++ G + FENV F YPSR IL G E G + ALVG SG GKST V L+ R Y
Sbjct: 492 PDSLHGEISFENVKFHYPSRPSVPILKGFTTTFEAGKTFALVGASGSGKSTVVSLIERFY 551
Query: 2541 EPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRET----- 2377
+P +G V +DG D+R LN+ WLR +G+V QEP LF T+ N+ G GS E
Sbjct: 552 DPISGVVKLDGKDIRSLNLNWLRQQIGLVSQEPTLFGTTVRGNVEHGLIGSRYENASFEE 611
Query: 2376 ----MIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLD 2209
+ + C ANAHDFI K+P+GYDT++G+ G+ LSGGQKQRVAIAR ++ DP++LLLD
Sbjct: 612 KFELVKKACVDANAHDFIMKLPQGYDTMVGERGMLLSGGQKQRVAIARAIVSDPRILLLD 671
Query: 2208 EATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEEL 2029
EATSALD QSE IVQ AL+ AS+GRTTI IAHRLSTIR+AD+I G ++E G+H +L
Sbjct: 672 EATSALDTQSEGIVQDALDKASRGRTTITIAHRLSTIRDADRIYVMGGGEVLEQGSHNDL 731
Query: 2028 V-RLGGRYFDLVKAQQFKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGN 1852
+ G Y LV Q+ + +ID D +
Sbjct: 732 LANENGPYAQLVNNQKLAQEAAAEALQVDDDIDDPDDVVFGGPSSPMQ--------EKDR 783
Query: 1851 SLNDSFSGSKRSXXXXXXXXXXXXXXXXXXXEDGQITAGYLDIFK-NAKGNYLYMFLGTV 1675
L+ + +G + + Y + + N+ ++Y+ + +
Sbjct: 784 QLHRAVTGRSLASIAMDDIQAKRAEEVAGEDKIPSSFGLYARLLRMNSADKFIYI-IAFI 842
Query: 1674 FALIRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVL 1495
A+ G+ PALA++FG F + + ++ + + + F S
Sbjct: 843 AAICAGMVYPALAILFGKALSDFE-IQDPTELRDALSRRALWYFITALAAGFVIFFQSAG 901
Query: 1494 FAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQV 1315
F+ +L+ R + F + L D +FD ++ G + + LA ++ + + +
Sbjct: 902 FSHAGWDLNGVLRKKLFTSTLRHDIEWFDEEHNSTGAVTSNLADQPQKVQGLFGPTLGTI 961
Query: 1314 XXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIG-LAYKISLMNVEQIQNDDA--G 1144
C+ V G + K+ ++ ++++ A
Sbjct: 962 --IQSCATLLGGCIIGLCYGPLLALIGIACIPILVSGGYIRLKVVVLKDQRMKKLHAASA 1019
Query: 1143 RIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMC 964
+A E VKT+ LTR + + Y + K + + + ++ +Q + ++
Sbjct: 1020 HLASEAAGAVKTVASLTREKDVREIYSEALKAPMKLNFRTSIKSQCLFAASQGLTFCIIA 1079
Query: 963 FTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYR 784
+ +G I G ++ + + +++ ++ N + P+ KA ++A +F I
Sbjct: 1080 LVFYIGALWIINGKYTTASFYTVLNSIVFASIQAGNVFTFVPDASKANSSAASIFRSIDN 1139
Query: 783 KPR-TGDLMEG---DRPEIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPS 616
+P + EG D + G++ E V F YP RP +++ L G VALVGPS
Sbjct: 1140 EPAINAESSEGKVLDHEHVVGHVRIEGVHFRYPTRPGVRVLRNLTIDVPAGTYVALVGPS 1199
Query: 615 GSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVC 436
G GKST I MLERFYD G + +DG DI++L+L R+Q++LV QEP L+AGTIR N+
Sbjct: 1200 GCGKSTTIQMLERFYDPLAGRVTLDGIDIKELNLASYRSQISLVSQEPTLYAGTIRFNIL 1259
Query: 435 LG----LKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARAL 268
LG L++V ++I+ A + AN F+ +LP G DT+VG KG QLSGGQKQRIAIARAL
Sbjct: 1260 LGANKPLEEVTQDEIDSACKDANIYDFIVSLPDGFDTEVGGKGSQLSGGQKQRIAIARAL 1319
Query: 267 VRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGK 88
+R+PK+LLLDEATSALDS+SE+ VQEALD+A +GRT I IAHRLSSIQ+SD I Y +G+
Sbjct: 1320 IRNPKVLLLDEATSALDSQSEKVVQEALDKAAKGRTTIAIAHRLSSIQHSDQIYYFSEGR 1379
Query: 87 VQEAGNHTQLMHQKGRYYKLIKKQDLA 7
V E G H +L+ +KG YY+L++ Q+L+
Sbjct: 1380 VAEQGTHQELLSKKGGYYELVQMQNLS 1406
>gi|24659289|ref|NP_648040.1| CG10226-PA [Drosophila melanogaster]
gi|7295352|gb|AAF50670.1| CG10226-PA [Drosophila melanogaster]
Length = 1320
Score = 662 bits (1708), Expect = 0.0
Identities = 433/1305 (33%), Positives = 665/1305 (50%), Gaps = 62/1305 (4%)
Frame = -1
Query: 3735 EAQP-VSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVS------------GRVT 3595
+AQP VS LFRY +DYL+L G + A + + PI +V G+ T
Sbjct: 31 KAQPMVSYTELFRYIAGWDYLVLLSGFVAAFLQSLVFPIAIVVYSELVAMFIERTLGQGT 90
Query: 3594 NALLV---------------YPPTSKQFRNKANENVYIFLGIGIFISITNFIQYM-CFQH 3463
+++ + Y ++ R K + + I + + + + + + Y+ F
Sbjct: 91 SSVTIGLSLFGGGKILTNASYEENMQELR-KDSVSFGILMTLNTLLMLFSGVYYVDAFNR 149
Query: 3462 CCTRVMAQMRHRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFA 3283
++ +MR F + LRQ GW D ++ D+ME+IR GI + LG +
Sbjct: 150 LALKLTVRMRREFFKATLRQEIGWHDMAKDQNFAVRITDNMEKIRSGIAENLGHYVEIMC 209
Query: 3282 MLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESL 3103
+I ++V+++IY W+LA ++ P + S +A T +E +A S+ EE +
Sbjct: 210 DVIISVVLSFIYGWKLALAIVFYIPLTLVVNSAVAHYQGKLTGQEQSSYVRASSVVEEVI 269
Query: 3102 MGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGA 2923
+RTV AF G+ RY++ L+ K WK YGA
Sbjct: 270 GAIRTVVAFGGERSESLRYDSLLKPALKAGKWKGAFSGLSDTVMKAMLFITGAGSFWYGA 329
Query: 2922 YLL------KVGIIT---TPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQT 2770
L+ + I TP V IV+ +++ A + SP + AR SA++I
Sbjct: 330 NLILYYRDPSIPIDEREYTPAVVMIVISGIIVSANQISRTSPFLETFAMARGSASAILDV 389
Query: 2769 IDRVPKIDPYSKAGKRLQ-NVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVG 2593
IDR IDP SKAGK L + G V+F +V FRYP+R+D +L GLN+VVE G +VALVG
Sbjct: 390 IDRTSLIDPLSKAGKILNYGLKGAVEFRDVFFRYPAREDVIVLRGLNVVVEEGQTVALVG 449
Query: 2592 HSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNN 2413
SGCGKST + LL R Y+P G V +DG DVR+ NI+WLR+ + +V QEP+LF +I N
Sbjct: 450 PSGCGKSTCIQLLQRFYDPVFGQVLLDGEDVRKYNIKWLRSNIAVVGQEPVLFQGSIGEN 509
Query: 2412 LLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIR 2233
+ G P +T++ + + K ANAHDFI + KGYDT I + GVQLSGGQ+QR+AIAR LI+
Sbjct: 510 IRHGKPEATQKEVEDAAKAANAHDFIIALHKGYDTDISEKGVQLSGGQRQRIAIARALIQ 569
Query: 2232 DPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIV 2053
PK+LLLDEATSALD SE +VQ+AL+ A KGRTT++++HRLS IR A +IV+ E G V
Sbjct: 570 QPKILLLDEATSALDYHSEKLVQAALDKACKGRTTLVVSHRLSAIRHAHRIVYIENGKAV 629
Query: 2052 EAGNHEELVRLGGRYFDLVKAQQFKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXS 1873
E G HEEL++L G Y +V + ++ +
Sbjct: 630 EQGTHEELMKLEGFYHKMVTVHSYDDSAEELLNELEEVAEIKE----------RKMSYEV 679
Query: 1872 EAFRRGNSLNDSFSGSKRSXXXXXXXXXXXXXXXXXXXEDGQI-TAGYLDIFKN----AK 1708
E ++ G + N S K + +D ++ +A ++ F A+
Sbjct: 680 EPYQLG-TRNSIVSLEKNAEFQMKNLNGLANITMNQEIDDPRVPSANFISTFFRILGWAR 738
Query: 1707 GNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVG 1528
+ ++ +G + A + G+ +P +++ ++ G P ++ + A I +G+
Sbjct: 739 PEWSFLIIGAICAGLYGVTMPVFSVVLAELY-GSLAKPTDEEVLEQSASMAIISLVIGIA 797
Query: 1527 VWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNI 1348
+ F + L+ R R ++FR ++ Q+ +FD ++ G L RL+ DA ++
Sbjct: 798 AGVVCYIQTFFFNLAGVWLTTRMRSKTFRCIMNQEMGWFDRKENSIGALSARLSGDAASV 857
Query: 1347 KAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVE 1168
+ + + + Y W+ F++ + ++
Sbjct: 858 QGAIGFPLSNIIQAFTNFICSIAIAFPYSWE---LALICLSTSPFMVASIVFEARFGEKS 914
Query: 1167 QIQN----DDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINY 1000
++ ++ RIA E I ++T+ L R E Y ++ + L + +
Sbjct: 915 ALKEKEVLEETSRIATETITQIRTVAGLRREEELIKIYDKEVERYRHQILSRLKWRGLVN 974
Query: 999 SLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAK 820
SL +S M+F T G + G + K M+ G + S + P F A
Sbjct: 975 SLGKSLMFFGYAVTLTYGGHMCADGKIKFETIMKISNTMLYGLFILAQSLAFTPAFNAAL 1034
Query: 819 TAAGMLFNIIYRKPRTGD------LMEGDRPEIRGNIL-----FENVKFSYPQRPLQPIM 673
+A ++ II RKP+ G+ + N++ + + FSYP RP ++
Sbjct: 1035 LSANRMYEIIDRKPQIQSPESFEIQQNGNGTAYKTNVVQQGVSYRGLNFSYPSRPHIKVL 1094
Query: 672 KGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDI-RKLSLFHLRTQ 496
+ +GQTVALVG SGSGKST + +L R+YD G + ID + I + L LR +
Sbjct: 1095 QNFNLDINQGQTVALVGASGSGKSTCVQLLMRYYDPDEGKILIDQESIHHDMDLKTLRRR 1154
Query: 495 MALVGQEPRLFAGTIRENVCLG--LKDVPLEKINQALELANANRFLANLPAGIDTDVGEK 322
+ +V QEP LF +I +N+ G + VP+++I +A ++ANA+ F+ +LPA DT +G K
Sbjct: 1155 LGIVSQEPSLFEKSIADNIGYGDTSRQVPMQQIIEAAKMANAHEFIMSLPAQYDTVLGSK 1214
Query: 321 GGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAH 142
G QLSGGQKQRIAIARA+VR+PKILLLDEATSALD +SER VQ+ALD A GRTCI IAH
Sbjct: 1215 GTQLSGGQKQRIAIARAMVRNPKILLLDEATSALDFQSERVVQQALDSACSGRTCIVIAH 1274
Query: 141 RLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQDLA 7
RLS+IQN+++I I GK+ E G+H+QL+ + G Y KL + Q A
Sbjct: 1275 RLSTIQNANVICVIQAGKIVEQGSHSQLLAKNGIYSKLYRCQTKA 1319
>gi|15226477|ref|NP_182223.1| multidrug resistant (MDR) ABC
transporter, putative [Arabidopsis thaliana]
gi|7442647|pir||T02187 probable ABC transporter [imported] -
Arabidopsis thaliana
gi|3522943|gb|AAC34225.1| putative ABC transporter [Arabidopsis
thaliana]
Length = 1286
Score = 662 bits (1708), Expect = 0.0
Identities = 402/1252 (32%), Positives = 662/1252 (52%), Gaps = 23/1252 (1%)
Frame = -1
Query: 3708 LFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKANENV- 3532
LF + FD+LL+ +GT+ +I +G+ P++ L+ G + +A + +K ++
Sbjct: 51 LFAFADSFDFLLMILGTLGSIGNGLGFPLMTLLFGDLIDA---FGENQTNTTDKVSKVAL 107
Query: 3531 -YIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFD-KNHSGTITT 3358
+++LGIG F + F+Q + R A++R ++ ++LRQ+ +FD ++G +
Sbjct: 108 KFVWLGIGTFAAA--FLQLSGWMISGERQAARIRSLYLKTILRQDIAFFDIDTNTGEVVG 165
Query: 3357 KLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLA 3178
+++ I++ +G+K+G ++ A + V+A++ W L +ML P + +LLA
Sbjct: 166 RMSGDTVLIQDAMGEKVGKAIQLLATFVGGFVIAFVRGWLLTLVMLSSIPLLVMAGALLA 225
Query: 3177 RQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXX 2998
+ T + KA ++ E+++ +RTV +F G+++ + Y L K V +
Sbjct: 226 IVIAKTASRGQTAYAKAATVVEQTIGSIRTVASFTGEKQAISNYNKHLVTAYKAGVIEGG 285
Query: 2997 XXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLISPHM 2818
+ YG L+ + T G V +++++L G+ LG SP +
Sbjct: 286 STGLGLGTLFLVVFCSYALAVWYGGKLI-LDKGYTGGQVLNIIIAVLTGSMSLGQTSPCL 344
Query: 2817 MVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKILNG 2638
+ +A +++TI+R P ID YS GK L ++ G ++ ++V+F YP+R D +I G
Sbjct: 345 SAFAAGQAAAYKMFETIERRPNIDSYSTNGKVLDDIKGDIELKDVYFTYPARPDEQIFRG 404
Query: 2637 LNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGI 2458
+L + GT+VALVG SG GKST V L+ R Y+P+AG+V IDG +++E ++W+R+ +G+
Sbjct: 405 FSLFISSGTTVALVGQSGSGKSTVVSLIERFYDPQAGDVLIDGINLKEFQLKWIRSKIGL 464
Query: 2457 VQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLS 2278
V QEP+LF +I +N+ G +T E + ++ANA F++K+P+G DT++G+ G QLS
Sbjct: 465 VSQEPVLFTASIKDNIAYGKEDATTEEIKAAAELANASKFVDKLPQGLDTMVGEHGTQLS 524
Query: 2277 GGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTI 2098
GGQKQR+A+AR +++DP++LLLDEATSALDA+SE +VQ AL+ RTT+++AHRLST+
Sbjct: 525 GGQKQRIAVARAILKDPRILLLDEATSALDAESERVVQEALDRIMVNRTTVVVAHRLSTV 584
Query: 2097 READKIVFFEKGVIVEAGNHEELVR-LGGRYFDLVKAQQFKADPXXXXXXXXXEIDLDDT 1921
R AD I +G IVE G+H EL++ G Y L++ Q+ K ++
Sbjct: 585 RNADMIAVIHQGKIVEKGSHTELLKDPEGAYSQLIRLQEEKKSDENAAEEQKMS-SIESF 643
Query: 1920 XXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXXXXXXXXXXXXXXXEDGQIT 1741
RGNS SF+ +
Sbjct: 644 KQSSLRKSSLGRSLSKGGSSRGNSSRHSFN---MFGFPAGIDGNVVQDQEEDDTTQPKTE 700
Query: 1740 AGYLDIFKNA---KGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGRMMHR 1570
+ IF+ A K + LG++ A G+ LP ++ V + F P ++
Sbjct: 701 PKKVSIFRIAALNKPEIPVLILGSISAAANGVILPIFGILISSVIKAFFQPP--KKLKED 758
Query: 1569 MAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAP 1390
+ I F +G + A + FA+ L R R F +++ + +FD P ++
Sbjct: 759 TSFWAIIFMVLGFASIIAYPAQTFFFAIAGCKLVQRIRSMCFEKVVHMEVGWFDEPENSS 818
Query: 1389 GKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFV 1210
G + RL++DA I+ +V + Q + CWQ LAFV
Sbjct: 819 GTIGARLSADAATIRGLVGDSLAQTVQNLSSILAGLIIAFLACWQ-----------LAFV 867
Query: 1209 MIGLAYKISLMNVEQIQ------------NDDAGRIAIEIIENVKTIQLLTRCELFFDHY 1066
++ + I+L ++ +A ++A + + +++T+ + + Y
Sbjct: 868 VLAMLPLIALNGFLYMKFMKGFSADAKKMYGEASQVANDAVGSIRTVASFCAEDKVMNMY 927
Query: 1065 QTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIA 886
+ ++ +++G++ I + + ++ ++ VG R++ G + D F+ A
Sbjct: 928 SKKCEGPMKNGIRQGIVSGIGFGFSFFVLFSSYAASFYVGARLVDDGKTTFDSVFRVFFA 987
Query: 885 MMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLMEGDR--PEIRGNILFENV 712
+ + A+A+ S+ P+ KA AA +F I+ R+ + +E R ++G+I +V
Sbjct: 988 LTMAAMAISQSSSLSPDSSKADVAAASIFAIMDRESKIDPSVESGRVLDNVKGDIELRHV 1047
Query: 711 KFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQD 532
F YP RP I + L + G+TVALVG SGSGKST I +L+RFYD G + +DG +
Sbjct: 1048 SFKYPARPDVQIFQDLCLSIRAGKTVALVGESGSGKSTVIALLQRFYDPDSGEITLDGVE 1107
Query: 531 IRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGL-KDVPLEKINQALELANANRFLANL 355
I+ L L LR Q LV QEP LF TIR N+ G D +I + EL+NA+ F++ L
Sbjct: 1108 IKSLRLKWLRQQTGLVSQEPILFNETIRANIAYGKGGDASESEIVSSAELSNAHGFISGL 1167
Query: 354 PAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRA 175
G DT VGE+G QLSGGQKQR+AIARA+V+DPK+LLLDEATSALD+ESER VQ+ALDR
Sbjct: 1168 QQGYDTMVGERGIQLSGGQKQRVAIARAIVKDPKVLLLDEATSALDAESERVVQDALDRV 1227
Query: 174 REGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQK-GRYYKLIK 22
RT I +AHRLS+I+N+D+I + G + E G H L++ K G Y L++
Sbjct: 1228 MVNRTTIVVAHRLSTIKNADVIAVVKNGVIVEKGKHDTLINIKDGVYASLVQ 1279
Score = 353 bits (905), Expect = 2e-95
Identities = 210/592 (35%), Positives = 326/592 (54%), Gaps = 4/592 (0%)
Frame = -1
Query: 3756 DIANQQLEAQPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVY 3577
D + E + VSI + K + +L +G+I A +GV PI ++ V A
Sbjct: 693 DTTQPKTEPKKVSIFRIAALNKP-EIPVLILGSISAAANGVILPIFGILISSVIKAFFQP 751
Query: 3576 PPTSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNA 3397
P K+ + + IF+ +G I Q F +++ ++R V+
Sbjct: 752 P---KKLKEDTSFWAIIFMVLGFASIIAYPAQTFFFAIAGCKLVQRIRSMCFEKVVHMEV 808
Query: 3396 GWFDK--NHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMM 3223
GWFD+ N SGTI +L+ IR +GD L ++ + ++A +++A++ W+LA ++
Sbjct: 809 GWFDEPENSSGTIGARLSADAATIRGLVGDSLAQTVQNLSSILAGLIIAFLACWQLAFVV 868
Query: 3222 LGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYE 3043
L + P + L + M + G+A +A +++ +RTV +F +++++ Y
Sbjct: 869 LAMLPLIALNGFLYMKFMKGFSADAKKMYGEASQVANDAVGSIRTVASFCAEDKVMNMYS 928
Query: 3042 AELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMS 2863
+ E K + + GA L+ G TT VF V +
Sbjct: 929 KKCEGPMKNGIRQGIVSGIGFGFSFFVLFSSYAASFYVGARLVDDGK-TTFDSVFRVFFA 987
Query: 2862 MLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENV 2683
+ + A + S A V+AASI+ +DR KIDP ++G+ L NV G ++ +V
Sbjct: 988 LTMAAMAISQSSSLSPDSSKADVAAASIFAIMDRESKIDPSVESGRVLDNVKGDIELRHV 1047
Query: 2682 HFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTD 2503
F+YP+R D +I L L + G +VALVG SG GKST + LL R Y+P++G +T+DG +
Sbjct: 1048 SFKYPARPDVQIFQDLCLSIRAGKTVALVGESGSGKSTVIALLQRFYDPDSGEITLDGVE 1107
Query: 2502 VRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRET-MIEVCKMANAHDFIEKM 2326
++ L ++WLR G+V QEPILFN+TI N+ G G E+ ++ +++NAH FI +
Sbjct: 1108 IKSLRLKWLRQQTGLVSQEPILFNETIRANIAYGKGGDASESEIVSSAELSNAHGFISGL 1167
Query: 2325 PKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNA 2146
+GYDT++G+ G+QLSGGQKQRVAIAR +++DPKVLLLDEATSALDA+SE +VQ AL+
Sbjct: 1168 QQGYDTMVGERGIQLSGGQKQRVAIARAIVKDPKVLLLDEATSALDAESERVVQDALDRV 1227
Query: 2145 SKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRL-GGRYFDLVK 1993
RTTI++AHRLSTI+ AD I + GVIVE G H+ L+ + G Y LV+
Sbjct: 1228 MVNRTTIVVAHRLSTIKNADVIAVVKNGVIVEKGKHDTLINIKDGVYASLVQ 1279
Score = 294 bits (752), Expect = 1e-77
Identities = 187/573 (32%), Positives = 306/573 (52%), Gaps = 9/573 (1%)
Frame = -1
Query: 1704 NYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGV 1525
++L M LGT+ ++ GL P + L+FG + + F +++ + F +G+G
Sbjct: 59 DFLLMILGTLGSIGNGLGFPLMTLLFGDLIDAFG--ENQTNTTDKVSKVALKFVWLGIGT 116
Query: 1524 WFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIK 1345
+ + + + E + R R + +L QD ++FD + G+++ R++ D I+
Sbjct: 117 FAAAFLQLSGWMISGERQAARIRSLYLKTILRQDIAFFDIDTNT-GEVVGRMSGDTVLIQ 175
Query: 1344 AVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQ 1165
+ ++ + + W VM G I +
Sbjct: 176 DAMGEKVGKAIQLLATFVGGFVIAFVRGW--LLTLVMLSSIPLLVMAGALLAIVIAKTAS 233
Query: 1164 IQNDDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKR--SELKKGMIEAINYSLT 991
+ A A ++E +TI + F Q S K + K G+IE + L
Sbjct: 234 -RGQTAYAKAATVVE--QTIGSIRTVASFTGEKQAISNYNKHLVTAYKAGVIEGGSTGLG 290
Query: 990 QSFMYFMMCFTYAVGI----RIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKA 823
++ ++ +YA+ + ++I + IIA++ G++++ ++ F
Sbjct: 291 LGTLFLVVFCSYALAVWYGGKLILDKGYTGGQVLNIIIAVLTGSMSLGQTSPCLSAFAAG 350
Query: 822 KTAAGMLFNIIYRKPRTGDLMEGDR--PEIRGNILFENVKFSYPQRPLQPIMKGLQWTAL 649
+ AA +F I R+P + +I+G+I ++V F+YP RP + I +G
Sbjct: 351 QAAAYKMFETIERRPNIDSYSTNGKVLDDIKGDIELKDVYFTYPARPDEQIFRGFSLFIS 410
Query: 648 RGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPR 469
G TVALVG SGSGKST + ++ERFYD G + IDG ++++ L +R+++ LV QEP
Sbjct: 411 SGTTVALVGQSGSGKSTVVSLIERFYDPQAGDVLIDGINLKEFQLKWIRSKIGLVSQEPV 470
Query: 468 LFAGTIRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQR 289
LF +I++N+ G +D E+I A ELANA++F+ LP G+DT VGE G QLSGGQKQR
Sbjct: 471 LFTASIKDNIAYGKEDATTEEIKAAAELANASKFVDKLPQGLDTMVGEHGTQLSGGQKQR 530
Query: 288 IAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLI 109
IA+ARA+++DP+ILLLDEATSALD+ESER VQEALDR RT + +AHRLS+++N+D+I
Sbjct: 531 IAVARAILKDPRILLLDEATSALDAESERVVQEALDRIMVNRTTVVVAHRLSTVRNADMI 590
Query: 108 VYIDKGKVQEAGNHTQLMHQ-KGRYYKLIKKQD 13
I +GK+ E G+HT+L+ +G Y +LI+ Q+
Sbjct: 591 AVIHQGKIVEKGSHTELLKDPEGAYSQLIRLQE 623
>gi|39594939|emb|CAE70807.1| Hypothetical protein CBG17569
[Caenorhabditis briggsae]
Length = 1224
Score = 660 bits (1702), Expect = 0.0
Identities = 415/1259 (32%), Positives = 655/1259 (51%), Gaps = 24/1259 (1%)
Frame = -1
Query: 3708 LFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQ---------- 3559
+F+ F+ LL +G ++++G+ QP ++ G V+ L+
Sbjct: 31 IFKCTSCFEKLLFMLGIFFSLLTGLCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEK 90
Query: 3558 ----FRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGW 3391
F N + F G +Q+ + ++R +++ +LR++A +
Sbjct: 91 AYEVFERDMNSVILHFFFCGCAYFTFGSLQFSIMKFVGDNTTYRVRKQYISRLLRKDARY 150
Query: 3390 FDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVA 3211
FD +G ++T LND++ER RE +K+ +++ +A+ +WRLAS G+
Sbjct: 151 FDSMSTGHLSTILNDNLERFREVFNEKIALIIAFATDFTVGTALAFYTDWRLASY--GIV 208
Query: 3210 PTCCICMSLL--ARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAE 3037
+ I S L + M T K+ AGSIA + L +TV + NGQ + + RY E
Sbjct: 209 FSLGIAFSGLINSASMMKNTDKQNAHYANAGSIAFQ-LGAYKTVCSLNGQRQEIERYTKE 267
Query: 3036 LEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSML 2857
L++G K+ +++ + +GA ++ G + T
Sbjct: 268 LKEGEKYGLYRALFYSISRGVTYFFCNALNTVVLYFGANMIYDGTLDT------------ 315
Query: 2856 LGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHF 2677
++ + + + + + + G +Q G + F++V F
Sbjct: 316 -----------------------GTVVRDDNEIERDEEDCEDGVDVQ---GNISFKDVKF 349
Query: 2676 RYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVR 2497
YP R DA++L G++ V+ G +ALVG SG GKST V LL Y E+GN+ IDG ++
Sbjct: 350 SYPIRPDAQVLKGISFDVKNGECIALVGASGSGKSTVVQLLLHYYNIESGNILIDGVELN 409
Query: 2496 ELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKG 2317
++N++ LR +G+V QEP+LFN TI N+ GN +T + + ANA+DF+ PKG
Sbjct: 410 KINLKKLRRVIGVVSQEPVLFNTTIEENIRFGNSEATLPEIYGALRKANAYDFVCAFPKG 469
Query: 2316 YDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKG 2137
T++G+ G QLSGGQKQR+AIARTL+R+PK+LLLDEATSALD +SE +VQ AL NAS+G
Sbjct: 470 IKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEHVVQKALENASQG 529
Query: 2136 RTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKADPXXXX 1957
RTTI++AHRLSTIR A+KI+ +KG IVE GNH+EL+ G Y DLV+AQ +
Sbjct: 530 RTTIVVAHRLSTIRNANKIIVMQKGEIVEVGNHDELISKQGAYNDLVQAQLLNSHDDHNE 589
Query: 1956 XXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXXXXXXXXX 1777
L S S+S + +
Sbjct: 590 LPPLTARQLSHEL----------------------SPLHSYSFQRSTSTDAGVHDDDMER 627
Query: 1776 XXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFV 1597
++G + +I K + +Y +FL + I+G+ P LA + ++G+
Sbjct: 628 LLDELTQEGAKKSNLREIVKMCRPDYCILFLAVFGSAIQGISYPILAQLIVRTYQGYAM- 686
Query: 1596 PYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDAS 1417
+G ++ ++F + V + F V+E LS R RV+SF+++L ++
Sbjct: 687 -HGEDILTYGHFWALSFMFLAVFRPLTLYLQYYYFGKVAEKLSTRLRVKSFKHMLSLPSA 745
Query: 1416 YFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXX 1237
++D+P H+ KL RL +D+ N+KA VD R+ V YCW+
Sbjct: 746 FYDDPKHSATKLSNRLNTDSSNVKAAVDDRLGCVIMTLVAISIAVITAANYCWKMTLEVL 805
Query: 1236 XXXXXLAFVMIGLA---YKISLMNVEQ---IQNDDAGRIAIEIIENVKTIQLLTRCELFF 1075
F ++ LA Y+ + N Q I +++ R AIE +ENV+T++ L +
Sbjct: 806 MF-----FPLLYLAEYCYEAATENAIQEDSIAFENSNRTAIEALENVRTVRALNLEDKVM 860
Query: 1074 DHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKG 895
++ S K+ +I+ L+ S F+ ++ G+ + + + +T+
Sbjct: 861 SSITNHLQKIHNSYFKRAIIQGAANGLSMSCFLFVYSISFKFGVYLALRKEVEPMNTYLV 920
Query: 894 IIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNII-YRKPRTGDLMEGDRPEIRGNILFE 718
++ + + A ++A Y P++ KA AAG++FN+ Y D +G + +G I+ E
Sbjct: 921 LMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFNMFTYPATMPYDSSDGRKNIEKGEIVGE 980
Query: 717 NVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDG 538
N++F Y QRP + I+ G+ G+T+ALVGPSG GKST I +LERFY VT G ++ID
Sbjct: 981 NLQFHYDQRPDRMILNGVNLKVEPGKTLALVGPSGCGKSTIISLLERFYHVTNGEIKIDR 1040
Query: 537 QDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGL-KDVPLEKINQALELANANRFLA 361
+++ ++L HLR +ALV QEP LF +IREN+ GL + VP +I +AL+ ANA F+
Sbjct: 1041 ENVEDINLHHLRANIALVSQEPTLFNCSIRENLLYGLTRQVPQLEIEKALQTANAFHFVY 1100
Query: 360 NLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALD 181
P G+DT VGE+G QLSGGQKQRIAIARA++R+PK+LLLDEATSALDS+SE+ VQ ALD
Sbjct: 1101 QFPQGLDTIVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALD 1160
Query: 180 RAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQDLAV 4
A E + + +AHRLS++ N+D I + GKV E G H +L+ + Y+ L++KQ + V
Sbjct: 1161 TASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRLRSVYWGLVQKQGMHV 1219
>gi|49080124|ref|XP_403624.1| hypothetical protein UM06009.1 [Ustilago
maydis 521]
gi|46101640|gb|EAK86873.1| hypothetical protein UM06009.1 [Ustilago
maydis 521]
Length = 1470
Score = 659 bits (1701), Expect = 0.0
Identities = 421/1293 (32%), Positives = 648/1293 (49%), Gaps = 60/1293 (4%)
Frame = -1
Query: 3708 LFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYP----------PTSKQ 3559
L+RY +D++ IG I A +G QP++ +V G +T A L Y
Sbjct: 181 LYRYATVWDHIFNLIGLIAAAAAGAVQPLMTIVFGSLTTAFLEYSNALLFNGDILTARDH 240
Query: 3558 FRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFDKN 3379
++ V + IGI + + ++ + + + + R +++ ++LRQ+ +FD
Sbjct: 241 LDHEIVHGVLFLVYIGIAMLVATYVYMAAWVYTGEVITRRTREKYLEAILRQDIAYFDLV 300
Query: 3378 HSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCC 3199
+G ITT++ ++ I+EGI DK+ + + + + +VAY+ W+LA + + P
Sbjct: 301 GAGEITTRIQTDIQLIQEGISDKIPMSVMFISAFVTGFIVAYVKSWQLALALSSMIPCII 360
Query: 3198 ICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRK 3019
I +L+ EL V KA SIAEE+L +RT +AF + ++V Y+ + +
Sbjct: 361 IAGALMNAVTAKLQQAELDRVSKAASIAEEALATLRTAKAFGIEHDLVQLYDQSNRQATR 420
Query: 3018 FAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFL 2839
F + + +GA LL G I + G V V+ S+L+GA+ +
Sbjct: 421 FGIKRSLYQGIGMGVFFFVIYSGYALAFYFGAKLLASGHIAS-GTVMNVIFSILIGAFSM 479
Query: 2838 GLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRK 2659
+++P+M L A + A +++TIDRVP ID +G R + G ++F + F YP+R
Sbjct: 480 AMMAPNMQALSYAFAAGAKVFETIDRVPPIDSSDPSGLRPEACQGHLEFHQIDFSYPTRP 539
Query: 2658 DAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEW 2479
D +L +L V G ALVG SG GKST V L+ R Y+P+AG V +D DVR+LN++W
Sbjct: 540 DVPVLEAFSLQVPAGKVTALVGASGSGKSTIVSLVERFYDPDAGAVLLDCVDVRDLNLKW 599
Query: 2478 LRNTVGIVQQEPILFNDTIHNNL---LIGNP------GSTRETMIEVCKMANAHDFIEKM 2326
LR +G+V QEP LF+ TI N+ LI P ++ +I+ MANAH FI ++
Sbjct: 600 LRTQIGLVSQEPTLFSTTIRANIAHGLINTPFQHASEQEQQKLIIDAANMANAHGFISQL 659
Query: 2325 PKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNA 2146
P GYDT++G+ G LSGGQKQR+AIAR ++++P +LLLDEATSALD QSE++VQ AL A
Sbjct: 660 PNGYDTMVGERGFLLSGGQKQRIAIARAIVKNPSILLLDEATSALDTQSEAVVQDALEQA 719
Query: 2145 SKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKADPX 1966
S+ RTTI IAHRLSTI+ ADKIV KGVI+E G H EL+ L G Y LV AQ +A
Sbjct: 720 SQNRTTITIAHRLSTIKNADKIVVMGKGVILETGQHNELLELNGAYAQLVDAQNIRAKVG 779
Query: 1965 XXXXXXXXEIDLDD----------TXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRS 1816
D DD ++A R + + +G ++S
Sbjct: 780 NKIVEEGVIDDDDDDDDQQAAQPAKFVASNAKVPLAVTDDAKAAVRQEAKAEMPAGLEKS 839
Query: 1815 XXXXXXXXXXXXXXXXXXXEDGQ----ITAGYLDIFKNAKGNYLYMFL----GTVFALIR 1660
+ I + + +++ AK N ++F G + ++
Sbjct: 840 VTHQSVASAILHQRQREQATRDEEPEKIPSIFYLLYRLAKINRDHVFTLYVPGVIASICS 899
Query: 1659 GLELPALALIFGWVFEGFTFV----------PYGGRMMHRMAMAVIAFASVGVGVWFSQL 1510
G P +L+FG + F+ P M+H + + F + + +
Sbjct: 900 GAAYPCFSLLFGHALQNFSLCSAIGGGACPEPARSTMLHDANLWALYFFVIAILCTLAIS 959
Query: 1509 ASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDA 1330
+ S L R R S L D SY D AH+ G L LA ++ I +V
Sbjct: 960 IQTYTLMKASCVLMERMRRMSLFAYLRADVSYHDQDAHSSGALSNSLADNSQKINGLVGV 1019
Query: 1329 RMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXX---XXXXLAFVMIGLAYKISLMNVEQIQ 1159
+ + W+ FV + L + ++
Sbjct: 1020 TLGTIIQSISTLVTGAIIALANGWKLSLVVIACIPLTLSAGFVRLHLVV-LKDARLKTAY 1078
Query: 1158 NDDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFM 979
A + A E ++ + LTR + + Y+ R Y+++Q+
Sbjct: 1079 EGSAAK-ACEAAGAMRVVASLTREQDCLEIYRRELDAPSRISRNTAFYGNFLYAVSQALQ 1137
Query: 978 YFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLF 799
++++ + G +++ G+ +S F + A++ G++ N+ + P+ AKTAA
Sbjct: 1138 FWIIGLGFWYGSKLLISGEYTSGQYFTILTAVVFGSIQASNAFSFVPDISNAKTAAWDSI 1197
Query: 798 NIIYRKPR------TGDLMEGDRPEIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQT 637
++ P G++++ ++ G++ + V F YP RP +++G+ G
Sbjct: 1198 KLLDMVPEIDVTSDQGEVLD----KVEGHVRLDKVHFRYPTRPTVKVLRGVDIEVKPGTF 1253
Query: 636 VALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAG 457
VALVG SG GKST + +++RFYD G + IDG+DIR L+L +R MALV QEP L+ G
Sbjct: 1254 VALVGASGCGKSTTVQLMQRFYDPLSGRVLIDGKDIRTLNLAEIRKHMALVSQEPTLYDG 1313
Query: 456 TIRENVCLG----LKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQR 289
+I N+ LG V ++ + A AN F+ +LP DT VG KG QLSGGQKQR
Sbjct: 1314 SIEFNIRLGAFQDASSVSMDDLRAAAASANILAFIESLPDKWDTQVGAKGTQLSGGQKQR 1373
Query: 288 IAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLI 109
IAIARAL+R+P+ILLLDEATSALDS+SE+ VQEALD+A GRT I IAHRLS+I +DLI
Sbjct: 1374 IAIARALIRNPRILLLDEATSALDSDSEKLVQEALDKAAAGRTTIAIAHRLSTISRADLI 1433
Query: 108 VYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQDL 10
+ GKV E G+H L+++ G Y L++ Q L
Sbjct: 1434 YVLKDGKVHEHGSHIDLLNRNGVYADLVRMQHL 1466
Score = 308 bits (789), Expect = 7e-82
Identities = 222/700 (31%), Positives = 348/700 (49%), Gaps = 34/700 (4%)
Frame = -1
Query: 3972 DDPDNRGFDDQRRPSQRSTVLAIPA---LAVNDPKSDPKIASDLPANYVDDDDDAPKMYT 3802
DD D+ DD ++ +Q + +A A LAV D D K A A K
Sbjct: 789 DDDDD---DDDQQAAQPAKFVASNAKVPLAVTD---DAKAAVRQEA----------KAEM 832
Query: 3801 PSLLEKILNYALCRGDIANQQLEAQ------PVSIPGLF-------RYGKKFDYLLLFIG 3661
P+ LEK + + I +Q+ Q P IP +F + + + L G
Sbjct: 833 PAGLEKSVTHQSVASAILHQRQREQATRDEEPEKIPSIFYLLYRLAKINRDHVFTLYVPG 892
Query: 3660 TICAIISGVSQPILALVSGRVTNALLVYP---------PTSKQFRNKANENVYIFLGIGI 3508
I +I SG + P +L+ G + P + AN F I I
Sbjct: 893 VIASICSGAAYPCFSLLFGHALQNFSLCSAIGGGACPEPARSTMLHDANLWALYFFVIAI 952
Query: 3507 FISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFDKN--HSGTITTKLNDSMER 3334
++ IQ +M +MR +++ LR + + D++ SG ++ L D+ ++
Sbjct: 953 LCTLAISIQTYTLMKASCVLMERMRRMSLFAYLRADVSYHDQDAHSSGALSNSLADNSQK 1012
Query: 3333 IREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTI 3154
I +G LG +++ + L+ ++A W+L+ +++ P + +S ++ +
Sbjct: 1013 INGLVGVTLGTIIQSISTLVTGAIIALANGWKLSLVVIACIP---LTLSAGFVRLHLVVL 1069
Query: 3153 KEL-IGVGKAGSIAE--ESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXX 2983
K+ + GS A+ E+ +R V + +++ + Y EL+ + +
Sbjct: 1070 KDARLKTAYEGSAAKACEAAGAMRVVASLTREQDCLEIYRRELDAPSRISRNTAFYGNFL 1129
Query: 2982 XXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLN 2803
G G YG+ LL G T+ G F ++ +++ G+ + + N
Sbjct: 1130 YAVSQALQFWIIGLGFWYGSKLLISGEYTS-GQYFTILTAVVFGSIQASNAFSFVPDISN 1188
Query: 2802 ARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVV 2623
A+ +A + +D VP+ID S G+ L V G V+ + VHFRYP+R K+L G+++ V
Sbjct: 1189 AKTAAWDSIKLLDMVPEIDVTSDQGEVLDKVEGHVRLDKVHFRYPTRPTVKVLRGVDIEV 1248
Query: 2622 EPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEP 2443
+PGT VALVG SGCGKST+V L+ R Y+P +G V IDG D+R LN+ +R + +V QEP
Sbjct: 1249 KPGTFVALVGASGCGKSTTVQLMQRFYDPLSGRVLIDGKDIRTLNLAEIRKHMALVSQEP 1308
Query: 2442 ILFNDTIHNNLLIGN----PGSTRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSG 2275
L++ +I N+ +G + + + AN FIE +P +DT +G G QLSG
Sbjct: 1309 TLYDGSIEFNIRLGAFQDASSVSMDDLRAAAASANILAFIESLPDKWDTQVGAKGTQLSG 1368
Query: 2274 GQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIR 2095
GQKQR+AIAR LIR+P++LLLDEATSALD+ SE +VQ AL+ A+ GRTTI IAHRLSTI
Sbjct: 1369 GQKQRIAIARALIRNPRILLLDEATSALDSDSEKLVQEALDKAAAGRTTIAIAHRLSTIS 1428
Query: 2094 EADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKA 1975
AD I + G + E G+H +L+ G Y DLV+ Q A
Sbjct: 1429 RADLIYVLKDGKVHEHGSHIDLLNRNGVYADLVRMQHLHA 1468
Score = 282 bits (721), Expect = 5e-74
Identities = 186/604 (30%), Positives = 301/604 (49%), Gaps = 28/604 (4%)
Frame = -1
Query: 1737 GYLDIFKNAK-GNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGRMM----- 1576
G+ ++++ A ++++ +G + A G P + ++FG + F + Y ++
Sbjct: 177 GFRELYRYATVWDHIFNLIGLIAAAAAGAVQPLMTIVFGSLTTAF--LEYSNALLFNGDI 234
Query: 1575 --------HRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDA 1420
H + V+ +G+ + + + E ++ R R + +L QD
Sbjct: 235 LTARDHLDHEIVHGVLFLVYIGIAMLVATYVYMAAWVYTGEVITRRTREKYLEAILRQDI 294
Query: 1419 SYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXX 1240
+YFD G++ TR+ +D I+ + ++ + WQ
Sbjct: 295 AYFD--LVGAGEITTRIQTDIQLIQEGISDKIPMSVMFISAFVTGFIVAYVKSWQLALAL 352
Query: 1239 XXXXXXLAFVMIGLAYKISLMNVEQIQND---DAGRIAIEIIENVKTIQLLTRCELFFDH 1069
++ G ++Q + D A IA E + ++T +
Sbjct: 353 SSMIP--CIIIAGALMNAVTAKLQQAELDRVSKAASIAEEALATLRTAKAFGIEHDLVQL 410
Query: 1068 YQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGII 889
Y S++Q R +K+ + + I + +Y + G +++ G +S I
Sbjct: 411 YDQSNRQATRFGIKRSLYQGIGMGVFFFVIYSGYALAFYFGAKLLASGHIASGTVMNVIF 470
Query: 888 AMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDL-MEGDRPEI-RGNILFEN 715
++++GA ++ A A A +F I R P G RPE +G++ F
Sbjct: 471 SILIGAFSMAMMAPNMQALSYAFAAGAKVFETIDRVPPIDSSDPSGLRPEACQGHLEFHQ 530
Query: 714 VKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQ 535
+ FSYP RP P+++ G+ ALVG SGSGKST + ++ERFYD GA+ +D
Sbjct: 531 IDFSYPTRPDVPVLEAFSLQVPAGKVTALVGASGSGKSTIVSLVERFYDPDAGAVLLDCV 590
Query: 534 DIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGLKDVPLEKINQ---------ALELA 382
D+R L+L LRTQ+ LV QEP LF+ TIR N+ GL + P + ++ A +A
Sbjct: 591 DVRDLNLKWLRTQIGLVSQEPTLFSTTIRANIAHGLINTPFQHASEQEQQKLIIDAANMA 650
Query: 381 NANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESER 202
NA+ F++ LP G DT VGE+G LSGGQKQRIAIARA+V++P ILLLDEATSALD++SE
Sbjct: 651 NAHGFISQLPNGYDTMVGERGFLLSGGQKQRIAIARAIVKNPSILLLDEATSALDTQSEA 710
Query: 201 AVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIK 22
VQ+AL++A + RT ITIAHRLS+I+N+D IV + KG + E G H +L+ G Y +L+
Sbjct: 711 VVQDALEQASQNRTTITIAHRLSTIKNADKIVVMGKGVILETGQHNELLELNGAYAQLVD 770
Query: 21 KQDL 10
Q++
Sbjct: 771 AQNI 774
>gi|11346278|pir||T43261 multidrug resistance protein 1 - fungus
(Filobasidium floriforme)
gi|2668553|gb|AAC49889.1| multidrug resistance protein 1
[Filobasidiella neoformans]
gi|2668555|gb|AAC49890.1| multidrug resistance protein 1
[Filobasidiella neoformans]
Length = 1408
Score = 657 bits (1695), Expect = 0.0
Identities = 423/1288 (32%), Positives = 666/1288 (50%), Gaps = 48/1288 (3%)
Frame = -1
Query: 3726 PVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVY---------- 3577
PVS LFR+ + + + +G + A+ +G QP++ L+ GR+T + Y
Sbjct: 138 PVSFFALFRFAAPLEIIAMVLGLVLAVAAGSCQPLMTLIFGRLTTSFTNYAVIANQISQG 197
Query: 3576 ---PPTSK-------QFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHR 3427
P TS + ++ N + IGI + + ++ + ++R R
Sbjct: 198 GLTPETSAALQAAKDDLKTQSGHNALYLMAIGIGMFLATWLYMFIWNVTGELNSKRIRER 257
Query: 3426 FVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIY 3247
++ +VLRQ +FD +G + T++ ++EG +K+ ++ + + V+A++
Sbjct: 258 YLAAVLRQEIAYFDDLGAGEVATRIQTDCHLVQEGTSEKVALVFQYAGTFVCGFVLAFVR 317
Query: 3246 EWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQ 3067
RLA ++ + P +C ++ M L + KAGS+AEE + +RTVQAF G+
Sbjct: 318 SPRLAGALVSILPVIMLCGGIMMTAMAKYGTAALDHIAKAGSLAEEVIGSIRTVQAF-GK 376
Query: 3066 EEMVG-RYEAELEK----GRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGI 2902
E+++G ++ +E+ GRK ++++ YG L+ G
Sbjct: 377 EKILGDKFADHIEQSKIVGRKGSIFEGFGLSIMFFVIYAAYALA----FFYGGILVSNGQ 432
Query: 2901 ITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKR 2722
+ G V V MS+L+G++ + +++P + + AR +AA ++ TIDRVP ID S+ G +
Sbjct: 433 ADS-GIVINVFMSILIGSFSMAMLAPELAAVTKARGAAAKLFATIDRVPAIDSASEEGFK 491
Query: 2721 LQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLY 2542
+ G + FENV F YPSR IL G E G + ALVG SG GKST V L+ R Y
Sbjct: 492 PDGLRGEISFENVKFHYPSRPSIPILKGFTTTFEAGKTFALVGASGSGKSTVVSLIERFY 551
Query: 2541 EPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRET----- 2377
+P +G V +DG D+R LN+ WLR +G+V QEP LF T+ N+ G GS E
Sbjct: 552 DPVSGVVKLDGRDIRSLNLNWLRQQIGLVSQEPTLFGTTVRGNVEHGLIGSRYENASLEE 611
Query: 2376 ----MIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLD 2209
+ + C ANAH+FI K+P+GYDT++G+ G+ LSGGQKQRVAIAR ++ DP++LLLD
Sbjct: 612 KFELVKKACVDANAHNFIMKLPQGYDTMVGERGMLLSGGQKQRVAIARAIVSDPRILLLD 671
Query: 2208 EATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEEL 2029
EATSALD QSE IVQ AL+ AS+GRTTI IAHRLSTIR+AD+I G ++E G+H +L
Sbjct: 672 EATSALDTQSEGIVQDALDKASRGRTTITIAHRLSTIRDADRIYVMGGGEVLEQGSHNDL 731
Query: 2028 V-RLGGRYFDLVKAQQFKADPXXXXXXXXXEI-DLDDTXXXXXXXXXXXXXXXSEAFRRG 1855
+ G Y LV Q+ + +I D DD +
Sbjct: 732 LANENGPYAQLVNNQKLAQEAAAEALQVDDDIEDPDDAVFIGGSSPMQ---------EKD 782
Query: 1854 NSLNDSFSGSKRSXXXXXXXXXXXXXXXXXXXEDGQITAGYLDIFK-NAKGNYLYMFLGT 1678
L+ + +G + + Y + + N+ ++Y+ +
Sbjct: 783 KQLHRAVTGRSLASIAMDDIQAKRAEEVAGEDKIPSSFGLYARLLRMNSADKFIYI-IAF 841
Query: 1677 VFALIRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSV 1498
+ A+ G+ P+LA++FG F + + H ++ + + + + F S
Sbjct: 842 IAAICAGMVYPSLAILFGKALSDFE-IQDPAELRHALSRSALWYFITALAAAFVIFFQSA 900
Query: 1497 LFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQ 1318
F+ +L+ R + F L D +FD ++ G + + LA ++ + +
Sbjct: 901 GFSRAGWDLNGVLRKKLFTATLRHDIEWFDEERNSTGAVTSNLADQPQKVQGLFGPTLGT 960
Query: 1317 VXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIG-LAYKISLMNVEQIQNDDA-- 1147
V C+ V G + K+ ++ ++++ A
Sbjct: 961 V--VQSCATLIGGCIIGLCYGPLLALIGIACIPILVSGGYIRLKVVVLKDQRMKKLHAAS 1018
Query: 1146 GRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMM 967
+A E VKT+ LTR + Y + K + + + ++ +Q + ++
Sbjct: 1019 AHLASEAAGAVKTVASLTREKDVRRIYSEALKAPMKLNFRTSIKSQCLFAASQGLTFCII 1078
Query: 966 CFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIY 787
+ +G I S+ + + +++ ++ N + P+ KA ++A +F I
Sbjct: 1079 ALVFYIGALWIIDAKYSTASFYTVLNSIVFASIQAGNVFTFVPDASKANSSAASIFRSID 1138
Query: 786 RKPR-TGDLMEG---DRPEIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGP 619
+P + EG D + G++ E V F YP RP +++ L G VALVGP
Sbjct: 1139 NEPAINAESNEGKVLDHKHVVGHVRIEGVHFRYPTRPGVRVLRNLTIDVPAGTYVALVGP 1198
Query: 618 SGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENV 439
SG GKST I MLERFYD G + +DG DI++L+L R+Q++LV QEP L+AGTIR N+
Sbjct: 1199 SGCGKSTTIQMLERFYDPLAGRVTLDGIDIKELNLASYRSQISLVSQEPTLYAGTIRFNI 1258
Query: 438 CLG----LKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARA 271
LG +++V ++I+ A + AN F+ +LP G DT+VG KG QLSGGQKQRIAIARA
Sbjct: 1259 LLGANKPIEEVTQDEIDAACKDANIYDFIVSLPDGFDTEVGGKGSQLSGGQKQRIAIARA 1318
Query: 270 LVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKG 91
L+R+PK+LLLDEATSALDS+SE+ VQEALD+A +GRT I IAHRLSSIQ+SD I Y +G
Sbjct: 1319 LIRNPKVLLLDEATSALDSQSEKVVQEALDKAAKGRTTIAIAHRLSSIQHSDRIYYFSEG 1378
Query: 90 KVQEAGNHTQLMHQKGRYYKLIKKQDLA 7
+V E G H +L+ +KG YY+L++ Q+L+
Sbjct: 1379 RVAEHGTHQELLAKKGGYYELVQMQNLS 1406
>gi|34894326|ref|NP_908488.1| unnamed protein product [Oryza sativa
(japonica cultivar-group)]
gi|8468012|dbj|BAA96612.1| unnamed protein product [Oryza sativa
(japonica cultivar-group)]
gi|27368863|emb|CAD59589.1| MDR-like ABC transporter [Oryza sativa
(japonica cultivar-group)]
Length = 1285
Score = 655 bits (1691), Expect = 0.0
Identities = 405/1262 (32%), Positives = 660/1262 (52%), Gaps = 13/1262 (1%)
Frame = -1
Query: 3771 ALCRGDIANQQLEAQPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTN 3592
A+ RG+ A + V LF + K D L+ +GT+ A+ +G + P + ++ G + +
Sbjct: 38 AVARGERAASASASARVPFHKLFAFADKTDAALMALGTLGAVANGAALPFMTVLFGNLID 97
Query: 3591 ALLVYPPTSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSV 3412
A N+ + F+ + I ++ +F+Q C+ R A++R+ ++ ++
Sbjct: 98 AF-GGAMGIHDVVNRVSMVSLEFIYLAIASAVASFVQVTCWMITGERQAARIRNLYLKTI 156
Query: 3411 LRQNAGWFDK-NHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRL 3235
LRQ +FDK ++G + +++ I++ +G+K+G ++ + +VA+ W L
Sbjct: 157 LRQEIAFFDKYTNTGEVVGRMSGDTVLIQDAMGEKVGKFIQLVVTFLGGFIVAFAQGWLL 216
Query: 3234 ASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMV 3055
+M+ P + ++++ + ++ + E+++ +RTV +F G+++ V
Sbjct: 217 TLVMMATIPPLVVAGAVMSNVVAKMASLGQAAYAESSVVVEQTIGSIRTVASFTGEKQAV 276
Query: 3054 GRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFI 2875
+Y L+ K V + G+ YGA L+ + T V
Sbjct: 277 EKYNKSLKSAYKSGVREGLAAGLGMGTVMVLLFCGYSLGIWYGAKLILLKGYTG-AKVMN 335
Query: 2874 VVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVK 2695
V+ ++L G+ LG SP M + +A +++TI+R P+ID YS G + ++ G ++
Sbjct: 336 VIFAVLTGSLALGQASPSMKAFAGGQAAAYKMFETINRKPEIDAYSTTGMKPDDIRGDIE 395
Query: 2694 FENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTI 2515
F +V+F YP+R D +I G +L + GT+VALVG SG GKST + L+ R Y+P+ G+V I
Sbjct: 396 FRDVYFSYPTRPDEQIFRGFSLSIPSGTTVALVGQSGSGKSTVISLIERFYDPQLGDVLI 455
Query: 2514 DGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFI 2335
DG +++E + W+R+ +G+V QEP+LF +I N+ G +T + + ++ANA FI
Sbjct: 456 DGVNLKEFQLRWIRSKIGLVSQEPVLFAASIKENIAYGKDNATDQEIRAAAELANASKFI 515
Query: 2334 EKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSAL 2155
+KMP+G DT +G+ G QLSGGQKQR+AIAR +++DP++LLLDEATSALDA+SE IVQ AL
Sbjct: 516 DKMPQGLDTSVGEHGTQLSGGQKQRIAIARAILKDPRILLLDEATSALDAESERIVQEAL 575
Query: 2154 NNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVR-LGGRYFDLVKAQQFK 1978
+ RTT+++AHRLST+R AD I +G +VE G H EL++ G Y L+K Q+
Sbjct: 576 DRVMTNRTTVIVAHRLSTVRNADTIAVIHQGTLVEKGPHHELLKDPEGAYSQLIKLQEAN 635
Query: 1977 ADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXX 1798
D D A R S D+ S S
Sbjct: 636 RQ------------DKSDRKGDSGARSGKQLSINQSASRSRRSSRDN-SHHSFSVPFGMP 682
Query: 1797 XXXXXXXXXXXXXEDGQITAGYLDIFKNA-KGNYLYMFLGTVFALIRGLELPALALIFGW 1621
DG L + K + LG++ ++I G+ P A++
Sbjct: 683 LGIDIQDGSSDNLCDGMPQDVPLSRLASLNKPEIPVLILGSIASVISGVIFPIFAILLSN 742
Query: 1620 VFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFR 1441
V + F P+ R + ++ F G + S SS LF++ L R R+ +F
Sbjct: 743 VIKAFYEPPHLLRKDSQFWSSM--FLVFGAVYFLSLPVSSYLFSIAGCRLIKRIRLMTFE 800
Query: 1440 NLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYC 1261
++ + +FD+P ++ G + RL++DA ++ +V + V +
Sbjct: 801 KVVNMEIEWFDHPENSSGAIGARLSADAAKVRGLVGDALQLVVQNTTTLIAGLVIAFVSN 860
Query: 1260 WQXXXXXXXXXXXLAFVMIGLAYKISLMNVE------QIQNDDAGRIAIEIIENVKTIQL 1099
W+ +IGL I + ++ ++ ++A ++A + + +++T+
Sbjct: 861 WE-----LSLIILALIPLIGLNGWIQMKFIQGFSADAKMMYEEASQVANDAVSSIRTVVS 915
Query: 1098 LTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDK 919
+ E D Y+ + R+ ++ G+I I + ++ ++ + ++ G R++ +
Sbjct: 916 FSAEEKVMDLYKKKCEGPLRTGIRTGIISGIGFGVSFFLLFGVYAASFYAGARLVEENKT 975
Query: 918 SSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLMEG--DRP 745
+ F+ +A+ + A+ V S+ + KAK+A +F I+ RK R +
Sbjct: 976 TFPKVFRVFLALAMAAIGVSQSSTLTSDSSKAKSAVSSIFAIVDRKSRIDPSEDAGVTVE 1035
Query: 744 EIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDV 565
+ GNI F++V F YP RP I + L T G+TVALVG SGSGKST I +L+RFYD
Sbjct: 1036 TLHGNIEFQHVSFRYPTRPDVEIFRDLCLTIHSGKTVALVGESGSGKSTAISLLQRFYDP 1095
Query: 564 TGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGLKDVPLE-KINQALE 388
G + +DG DI+K L LR QM LV QEP LF T+R N+ G + E +I +A +
Sbjct: 1096 DVGHILLDGVDIQKFQLKWLRQQMGLVSQEPALFNDTVRANIAYGKEGEATESEIIEAAK 1155
Query: 387 LANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSES 208
LANA++F+++ G T VGE+G QLSGGQKQRIAIARA+V+DPKILLLDEATSALD+ES
Sbjct: 1156 LANAHKFISSSHQGYGTTVGERGAQLSGGQKQRIAIARAIVKDPKILLLDEATSALDAES 1215
Query: 207 ERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQK-GRYYK 31
ER VQ+ALDR RT + +AHRLS+IQN+DLI + G + E G H LM+ K G Y
Sbjct: 1216 ERVVQDALDRVMVNRTTVIVAHRLSTIQNADLIAVVKNGVIIEKGKHDTLMNIKDGAYAS 1275
Query: 30 LI 25
L+
Sbjct: 1276 LV 1277
Score = 292 bits (747), Expect = 5e-77
Identities = 187/571 (32%), Positives = 302/571 (52%), Gaps = 11/571 (1%)
Frame = -1
Query: 1692 MFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGRM-----MHRMAMAVIAFASVGVG 1528
M LGT+ A+ G LP + ++FG + + F GG M ++R++M + F + +
Sbjct: 71 MALGTLGAVANGAALPFMTVLFGNLIDAF-----GGAMGIHDVVNRVSMVSLEFIYLAIA 125
Query: 1527 VWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNI 1348
+ + + E + R R + +L Q+ ++FD + G+++ R++ D I
Sbjct: 126 SAVASFVQVTCWMITGERQAARIRNLYLKTILRQEIAFFDKYTNT-GEVVGRMSGDTVLI 184
Query: 1347 KAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXX---XXLAFVMIGLAYKISLM 1177
+ + ++ + W VM + K++ +
Sbjct: 185 QDAMGEKVGKFIQLVVTFLGGFIVAFAQGWLLTLVMMATIPPLVVAGAVMSNVVAKMASL 244
Query: 1176 NVEQIQNDDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYS 997
Q ++ + + I +++T+ T + + Y S K +S +++G+ +
Sbjct: 245 G--QAAYAESSVVVEQTIGSIRTVASFTGEKQAVEKYNKSLKSAYKSGVREGLAAGLGMG 302
Query: 996 LTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKT 817
++ G ++I + I A++ G++A+ ++ F +
Sbjct: 303 TVMVLLFCGYSLGIWYGAKLILLKGYTGAKVMNVIFAVLTGSLALGQASPSMKAFAGGQA 362
Query: 816 AAGMLFNIIYRKPRTGDLME-GDRPE-IRGNILFENVKFSYPQRPLQPIMKGLQWTALRG 643
AA +F I RKP G +P+ IRG+I F +V FSYP RP + I +G + G
Sbjct: 363 AAYKMFETINRKPEIDAYSTTGMKPDDIRGDIEFRDVYFSYPTRPDEQIFRGFSLSIPSG 422
Query: 642 QTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLF 463
TVALVG SGSGKST I ++ERFYD G + IDG ++++ L +R+++ LV QEP LF
Sbjct: 423 TTVALVGQSGSGKSTVISLIERFYDPQLGDVLIDGVNLKEFQLRWIRSKIGLVSQEPVLF 482
Query: 462 AGTIRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIA 283
A +I+EN+ G + ++I A ELANA++F+ +P G+DT VGE G QLSGGQKQRIA
Sbjct: 483 AASIKENIAYGKDNATDQEIRAAAELANASKFIDKMPQGLDTSVGEHGTQLSGGQKQRIA 542
Query: 282 IARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVY 103
IARA+++DP+ILLLDEATSALD+ESER VQEALDR RT + +AHRLS+++N+D I
Sbjct: 543 IARAILKDPRILLLDEATSALDAESERIVQEALDRVMTNRTTVIVAHRLSTVRNADTIAV 602
Query: 102 IDKGKVQEAGNHTQLMHQ-KGRYYKLIKKQD 13
I +G + E G H +L+ +G Y +LIK Q+
Sbjct: 603 IHQGTLVEKGPHHELLKDPEGAYSQLIKLQE 633
>gi|34913530|ref|NP_918112.1| putative multidrug resistance protein
[Oryza sativa (japonica cultivar-group)]
gi|20146370|dbj|BAB89151.1| putative multidrug resistance protein
[Oryza sativa (japonica cultivar-group)]
gi|27368871|emb|CAD59593.1| MDR-like ABC transporter [Oryza sativa
(japonica cultivar-group)]
Length = 1287
Score = 655 bits (1689), Expect = 0.0
Identities = 395/1245 (31%), Positives = 645/1245 (51%), Gaps = 11/1245 (0%)
Frame = -1
Query: 3723 VSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKA 3544
V++ +F + D L+ +G A+ +G++QP++ + G V NA +S K
Sbjct: 42 VAVRRMFAFADGADAALMAVGAAAAVANGMAQPLMTFIFGDVINAF--GSTSSPDVLAKV 99
Query: 3543 NENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFDKNHS-GT 3367
+ + F+ +GI + +Q C+ R A++R ++ ++LRQ+ +FDK S G
Sbjct: 100 TKVILNFVYLGIGAGFVSTLQVSCWTITGERQAARIRALYLKAILRQDIAFFDKEMSTGQ 159
Query: 3366 ITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMS 3187
+ +++ I++ IG+K G ++ + ++A++ W LA ++L P + +
Sbjct: 160 VVERMSGDTFLIQDAIGEKSGKCIQLLSTFFGGFIIAFVRGWLLALVLLSCIPPIAVAGA 219
Query: 3186 LLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVW 3007
++R MT + + G AG+IAE+++ +RTV +FNG+++ + Y + K + +
Sbjct: 220 FVSRLMTRISTRMQEKYGDAGNIAEQTIGAIRTVASFNGEKQAINTYNKFIRKAYESTLQ 279
Query: 3006 KXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLIS 2827
+ G + YG+ L+ V G V V+MS+++GA LG +
Sbjct: 280 EGVVNGLGLGTVMAILFCSYGLAVWYGSKLI-VNRGYNGGIVINVLMSVMMGAMSLGQAT 338
Query: 2826 PHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKI 2647
P + + +A +++TI R P ID G L+++ G V+ ++V+F YP+R + +
Sbjct: 339 PSITAFAEGQGAAYRMFKTIKRQPDIDVCDTKGIILEDITGDVELKDVYFSYPTRPEYLV 398
Query: 2646 LNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNT 2467
NG +L + G ++ALVG SG GKST + L+ R Y+P++G V IDG D+R +N+ W+R
Sbjct: 399 FNGFSLQIPSGRTMALVGESGSGKSTVISLVERFYDPQSGEVLIDGIDIRRMNLGWIRGK 458
Query: 2466 VGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGV 2287
+ +V QEP+LF+ TI N+ G T E + ++ANA F++K+P G +T++G+ G+
Sbjct: 459 ISLVSQEPVLFSSTIRENIAYGKEDQTLEEIKRAVELANAAKFVDKLPNGLETMVGERGI 518
Query: 2286 QLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRL 2107
QLSGGQKQR+AIAR +I++P++LLLDEATSALD +SE +VQ ALN RTTI++AHRL
Sbjct: 519 QLSGGQKQRIAIARAIIKNPRILLLDEATSALDMESERVVQDALNRVMLERTTIIVAHRL 578
Query: 2106 STIREADKIVFFEKGVIVEAGNHEELVRL-GGRYFDLVKAQQFKADPXXXXXXXXXEIDL 1930
ST++ AD I ++G +VE G+H EL++ G Y L++ Q + D I
Sbjct: 579 STVKNADVISVLQQGKMVEQGSHVELMKKPEGAYAQLIQLQGAQQDAEIHNDDTDMIIRS 638
Query: 1929 DDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXXXXXXXXXXXXXXXED- 1753
D + +G+S S + D
Sbjct: 639 DSGSRSINVKPRSQSTSFRRSITKGSSFGHSGRHPIPAPLDFPDPMEFKDDLGMEETTDK 698
Query: 1752 ---GQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGR 1582
GQ A +F K + LG+V A + GL P ++ + F P
Sbjct: 699 VPRGQKKASISRLFYLNKPEAFVLVLGSVTAAMHGLMFPIFGILISSAIKMFYEPP--SE 756
Query: 1581 MMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNP 1402
++ F VG + LF + L R R +FR++++Q+ ++FD P
Sbjct: 757 LLKDSRFWASMFVVVGASAFVLIPTEYFLFGLAGGKLVERIRSLTFRSVMHQEINWFDKP 816
Query: 1401 AHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXX 1222
H+ G + RL+ DA N+K +V + + W+
Sbjct: 817 EHSSGSIGARLSVDALNVKRLVGDNLALNVQTVSTVISGFTIAMVANWKLALIITVVVPL 876
Query: 1221 LAFVMIGLAYKISLMNVE-QIQNDDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQ 1045
+ F + N +++ ++A ++A + + ++T+ + + Y+ +
Sbjct: 877 VGFQAYAQMKFLKGFNKNAKLKYEEASQVATDAVGGIRTVASFCAEQKVIEAYEKKCESP 936
Query: 1044 KRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVA 865
R +++G++ + + + YF + VG + ++QG + + F+ ++L
Sbjct: 937 VRQGIREGVVGGLGFGFSFLVFYFTYALCFYVGAKFVHQGVATFPEVFRVFFVLVLATSG 996
Query: 864 VMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLMEGD--RPEIRGNILFENVKFSYPQR 691
+ ++ + KA +A +F I+ RK + E +RG+I F NV F+YP R
Sbjct: 997 ISRTSAIGADSTKANESAVSIFEILDRKSKIDSSSEEGVVIASVRGDIEFHNVCFNYPLR 1056
Query: 690 PLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLF 511
P I K L G+TVALVG SGSGKST I +LERFYD G + +DG D++ +
Sbjct: 1057 PNIQIFKDLSLCIPSGKTVALVGESGSGKSTAIALLERFYDPDTGKILLDGVDLKTFKVS 1116
Query: 510 HLRTQMALVGQEPRLFAGTIRENVCLGLKD-VPLEKINQALELANANRFLANLPAGIDTD 334
LR Q+ LV QEP LF TI N+ G ++ E+I A E ANA++F++ LP G T
Sbjct: 1117 WLRIQIGLVAQEPVLFNDTIHANIAYGKQEQASQEEIMAAAEAANAHQFISALPDGYSTV 1176
Query: 333 VGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCI 154
VGE+G QLSGGQKQR+AIARA+++DPK+LLLDEATSALD+ESER VQEALDR GRT +
Sbjct: 1177 VGERGIQLSGGQKQRVAIARAIMKDPKVLLLDEATSALDAESERVVQEALDRVMVGRTTV 1236
Query: 153 TIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQK-GRYYKLIK 22
+AHRLS+I+ +D+I + G + E G H +LM K G Y L++
Sbjct: 1237 VVAHRLSTIKGADIIGVLKNGAIVEKGGHDELMRIKDGTYASLVE 1281
Score = 295 bits (754), Expect = 8e-78
Identities = 189/570 (33%), Positives = 306/570 (53%), Gaps = 11/570 (1%)
Frame = -1
Query: 1692 MFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQ 1513
M +G A+ G+ P + IFG V F ++ ++ ++ F +G+G F
Sbjct: 59 MAVGAAAAVANGMAQPLMTFIFGDVINAFGSTS-SPDVLAKVTKVILNFVYLGIGAGFVS 117
Query: 1512 LASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVD 1333
+ + E + R R + +L QD ++FD + G+++ R++ D I+ +
Sbjct: 118 TLQVSCWTITGERQAARIRALYLKAILRQDIAFFDKEM-STGQVVERMSGDTFLIQDAIG 176
Query: 1332 ARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXX----XXXXLAFVMIGLAYKISLMNVEQ 1165
+ + + W AFV L +IS E+
Sbjct: 177 EKSGKCIQLLSTFFGGFIIAFVRGWLLALVLLSCIPPIAVAGAFVS-RLMTRISTRMQEK 235
Query: 1164 IQNDDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQS 985
DAG IA + I ++T+ + + Y ++ S L++G++ + +
Sbjct: 236 Y--GDAGNIAEQTIGAIRTVASFNGEKQAINTYNKFIRKAYESTLQEGVVNGLGLGTVMA 293
Query: 984 FMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGM 805
++ G ++I + ++++M+GA+++ + F + + AA
Sbjct: 294 ILFCSYGLAVWYGSKLIVNRGYNGGIVINVLMSVMMGAMSLGQATPSITAFAEGQGAAYR 353
Query: 804 LFNIIYRKP------RTGDLMEGDRPEIRGNILFENVKFSYPQRPLQPIMKGLQWTALRG 643
+F I R+P G ++E +I G++ ++V FSYP RP + G G
Sbjct: 354 MFKTIKRQPDIDVCDTKGIILE----DITGDVELKDVYFSYPTRPEYLVFNGFSLQIPSG 409
Query: 642 QTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLF 463
+T+ALVG SGSGKST I ++ERFYD G + IDG DIR+++L +R +++LV QEP LF
Sbjct: 410 RTMALVGESGSGKSTVISLVERFYDPQSGEVLIDGIDIRRMNLGWIRGKISLVSQEPVLF 469
Query: 462 AGTIRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIA 283
+ TIREN+ G +D LE+I +A+ELANA +F+ LP G++T VGE+G QLSGGQKQRIA
Sbjct: 470 SSTIRENIAYGKEDQTLEEIKRAVELANAAKFVDKLPNGLETMVGERGIQLSGGQKQRIA 529
Query: 282 IARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVY 103
IARA++++P+ILLLDEATSALD ESER VQ+AL+R RT I +AHRLS+++N+D+I
Sbjct: 530 IARAIIKNPRILLLDEATSALDMESERVVQDALNRVMLERTTIIVAHRLSTVKNADVISV 589
Query: 102 IDKGKVQEAGNHTQLMHQ-KGRYYKLIKKQ 16
+ +GK+ E G+H +LM + +G Y +LI+ Q
Sbjct: 590 LQQGKMVEQGSHVELMKKPEGAYAQLIQLQ 619
>gi|14715462|dbj|BAB62040.1| CjMDR1 [Coptis japonica]
Length = 1289
Score = 652 bits (1682), Expect = 0.0
Identities = 393/1241 (31%), Positives = 636/1241 (50%), Gaps = 9/1241 (0%)
Frame = -1
Query: 3729 QPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFR- 3553
Q V L + D LL+ IGTI A+ +G S P++ L+ G + NA + R
Sbjct: 52 QSVPYYKLLSFADSKDVLLMVIGTIAAVANGASMPVMTLLLGDLINAFGQNANNTDTLRV 111
Query: 3552 --NKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFDKN 3379
A + VY+ +G G+ +F Q C+ R A++R ++ ++LRQ+ +FDK
Sbjct: 112 VSKVALKFVYLSIGAGV----ASFFQVACWMVTGERQAARIRSLYLKTILRQDVAFFDKE 167
Query: 3378 -HSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTC 3202
++G + +++ I++ IG+K+G ++ F+ I ++A++ W L +ML P
Sbjct: 168 TNTGEVVGRMSGDTVLIQDAIGEKVGKFIQLFSTFIGGFLIAFVKGWLLTLVMLTSIPPL 227
Query: 3201 CICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGR 3022
C +L+ ++ + + +AG + E+++ +RTV +F G++ V +YE L K
Sbjct: 228 VFCGALMTITISKMASRGQVAYSQAGIVVEQTIGSIRTVASFTGEKHAVTQYEKYLNKAY 287
Query: 3021 KFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYF 2842
+ + + +G ++ + G+V +++++L G+
Sbjct: 288 LAGIHEGLASGVGLGSVLLVIFCSYSLAVWFGGKMI-IEKGYNGGNVINIIVAVLTGSMS 346
Query: 2841 LGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSR 2662
LG SP + + +A + +TI R P+ID Y +G + ++ G ++ +V F YP+R
Sbjct: 347 LGQASPCLGAFAAGQAAAYKMLETIKRKPEIDSYDTSGHKSDDIRGDIELRDVSFTYPAR 406
Query: 2661 KDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIE 2482
D +I NG +L + GT+ ALVG SG GKST + L+ R Y+P+AG V IDG ++++ +
Sbjct: 407 PDEQIFNGFSLFIPSGTTSALVGQSGSGKSTVISLIERFYDPQAGEVLIDGVNLKDFQLR 466
Query: 2481 WLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYDTLI 2302
W+R +G+V QEP+LF +I +N+ G G+T E + + ANA FI+K+P+G DTL+
Sbjct: 467 WIRGKIGLVSQEPVLFASSIRDNIAYGKDGATVEEIKAATERANASKFIDKLPQGLDTLV 526
Query: 2301 GDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIM 2122
G+ G QLSGGQKQR+AIAR +++DP++LLLDEATSALDA+SE IVQ AL+ RTT++
Sbjct: 527 GEHGTQLSGGQKQRIAIARAILKDPRILLLDEATSALDAESEHIVQEALDRIMVNRTTVI 586
Query: 2121 IAHRLSTIREADKIVFFEKGVIVEAGNH-EELVRLGGRYFDLVKAQQFKADPXXXXXXXX 1945
+AHRLST+R AD I +G IVE G+H + L+ G Y L++ Q+
Sbjct: 587 VAHRLSTVRNADTIAVIHRGKIVEKGSHLDLLLNPDGAYCQLIRLQEIGRSEVDKAENVE 646
Query: 1944 XEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXXXXXXXXXXXXX 1765
++ GNS SFS S
Sbjct: 647 SGLNSSQQHSIGRSISRGSSGV-------GNSSRHSFSVSFGLPTGHIYETTAGLESTSP 699
Query: 1764 XXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGG 1585
+ K + LG + A++ G+ P ++ V + TF
Sbjct: 700 APIGQTQEVPLRRLATLNKPEIPVLLLGVISAMVNGVIFPIFGVLLSSVIK--TFYEPED 757
Query: 1584 RMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDN 1405
++ F +GV + + A++ FAV L R R FR + + + +FD
Sbjct: 758 KLRKDTRFWAFMFIILGVASFVAAPATAYFFAVAGCRLIQRIRSMCFRTVAHMEIDWFDE 817
Query: 1404 PAHAPGKLITRLASDAPNIKAVV-DARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXX 1228
P HA G + +L++DA ++ +V DA L V
Sbjct: 818 PEHASGAIGAKLSADASTVRGLVGDALALLVQNAATAVCGLVIAFVANWTLALIILVLIP 877
Query: 1227 XXLAFVMIGLAYKISLMNVEQIQNDDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQ 1048
+ + + ++ ++A ++A + + +++T+ E Y+ +
Sbjct: 878 LIGVNGYVQMKFMKGFSADAKMMYEEASQVANDAVGSIRTVASFCAEEKVMQLYKKKCEG 937
Query: 1047 QKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAV 868
++ +++G+I I + ++ ++ + ++ G R++ G + D F+ A+ + A+
Sbjct: 938 PMKTGIRQGLISGIGFGISFFLLFNVYATSFYAGARLVDAGKTTFSDVFRVFFALTMAAL 997
Query: 867 AVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLMEGDR--PEIRGNILFENVKFSYPQ 694
+ S+ P+ KAK++ +F I+ RK + E ++G I ++ F YP
Sbjct: 998 GISQSSSLAPDSSKAKSSTASIFGILDRKSKIDSSDESGMTVENVKGEIELRHISFKYPT 1057
Query: 693 RPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSL 514
RP I + L G+TVALVG SGSGKST I +L+RFYD G + +DG +I+K L
Sbjct: 1058 RPDIQIFRDLSLAIHSGKTVALVGESGSGKSTVISLLQRFYDPDSGHITLDGIEIQKFQL 1117
Query: 513 FHLRTQMALVGQEPRLFAGTIRENVCLGLK-DVPLEKINQALELANANRFLANLPAGIDT 337
LR QM LV QEP LF TIR N+ G + D +I A ELANA++F++ L G DT
Sbjct: 1118 RWLRLQMGLVSQEPVLFNETIRANIAYGKEGDATETEILAAAELANAHKFISGLQQGYDT 1177
Query: 336 DVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTC 157
VGE+G QLSGGQKQR+AIARA+V+ PKILLLDEATSALD+ESER VQ+ALD+ RT
Sbjct: 1178 VVGERGIQLSGGQKQRVAIARAMVKAPKILLLDEATSALDAESERVVQDALDKVMVNRTT 1237
Query: 156 ITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYY 34
+ +AHRLS+I+N+D+I + G + E G H L++ K Y
Sbjct: 1238 VWVAHRLSTIKNADVIAVVKNGVIAEKGKHNDLINVKDGVY 1278
Score = 338 bits (868), Expect = 5e-91
Identities = 195/565 (34%), Positives = 315/565 (55%), Gaps = 5/565 (0%)
Frame = -1
Query: 3675 LLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRN-KANENVYIFLGIGIFIS 3499
+L +G I A+++GV PI ++ V Y P K ++ + ++I LG+ F++
Sbjct: 723 VLLLGVISAMVNGVIFPIFGVLLSSVIKTF--YEPEDKLRKDTRFWAFMFIILGVASFVA 780
Query: 3498 ITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFDK--NHSGTITTKLNDSMERIRE 3325
+ C R++ ++R +V WFD+ + SG I KL+ +R
Sbjct: 781 APATAYFFAVAGC--RLIQRIRSMCFRTVAHMEIDWFDEPEHASGAIGAKLSADASTVRG 838
Query: 3324 GIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKEL 3145
+GD L +L++ A + +V+A++ W LA ++L + P + + + M +
Sbjct: 839 LVGDALALLVQNAATAVCGLVIAFVANWTLALIILVLIPLIGVNGYVQMKFMKGFSADAK 898
Query: 3144 IGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXX 2965
+ +A +A +++ +RTV +F +E+++ Y+ + E K + +
Sbjct: 899 MMYEEASQVANDAVGSIRTVASFCAEEKVMQLYKKKCEGPMKTGIRQGLISGIGFGISFF 958
Query: 2964 XXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAA 2785
GA L+ G TT DVF V ++ + A + S A+ S A
Sbjct: 959 LLFNVYATSFYAGARLVDAGK-TTFSDVFRVFFALTMAALGISQSSSLAPDSSKAKSSTA 1017
Query: 2784 SIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSV 2605
SI+ +DR KID ++G ++NV G ++ ++ F+YP+R D +I L+L + G +V
Sbjct: 1018 SIFGILDRKSKIDSSDESGMTVENVKGEIELRHISFKYPTRPDIQIFRDLSLAIHSGKTV 1077
Query: 2604 ALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDT 2425
ALVG SG GKST + LL R Y+P++G++T+DG ++++ + WLR +G+V QEP+LFN+T
Sbjct: 1078 ALVGESGSGKSTVISLLQRFYDPDSGHITLDGIEIQKFQLRWLRLQMGLVSQEPVLFNET 1137
Query: 2424 IHNNLLIGNPGSTRET-MIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIA 2248
I N+ G G ET ++ ++ANAH FI + +GYDT++G+ G+QLSGGQKQRVAIA
Sbjct: 1138 IRANIAYGKEGDATETEILAAAELANAHKFISGLQQGYDTVVGERGIQLSGGQKQRVAIA 1197
Query: 2247 RTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFE 2068
R +++ PK+LLLDEATSALDA+SE +VQ AL+ RTT+ +AHRLSTI+ AD I +
Sbjct: 1198 RAMVKAPKILLLDEATSALDAESERVVQDALDKVMVNRTTVWVAHRLSTIKNADVIAVVK 1257
Query: 2067 KGVIVEAGNHEELVRL-GGRYFDLV 1996
GVI E G H +L+ + G Y LV
Sbjct: 1258 NGVIAEKGKHNDLINVKDGVYASLV 1282
Score = 286 bits (732), Expect = 3e-75
Identities = 179/567 (31%), Positives = 288/567 (50%), Gaps = 4/567 (0%)
Frame = -1
Query: 1698 LYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWF 1519
L M +GT+ A+ G +P + L+ G + F + ++ + F + +G
Sbjct: 69 LLMVIGTIAAVANGASMPVMTLLLGDLINAFGQNANNTDTLRVVSKVALKFVYLSIGAGV 128
Query: 1518 SQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAV 1339
+ + V E + R R + +L QD ++FD + G+++ R++ D I+
Sbjct: 129 ASFFQVACWMVTGERQAARIRSLYLKTILRQDVAFFDKETNT-GEVVGRMSGDTVLIQDA 187
Query: 1338 VDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVE-QI 1162
+ ++ + + W L F + IS M Q+
Sbjct: 188 IGEKVGKFIQLFSTFIGGFLIAFVKGWLLTLVMLTSIPPLVFCGALMTITISKMASRGQV 247
Query: 1161 QNDDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSF 982
AG + + I +++T+ T + Y+ + + + +G+ +
Sbjct: 248 AYSQAGIVVEQTIGSIRTVASFTGEKHAVTQYEKYLNKAYLAGIHEGLASGVGLGSVLLV 307
Query: 981 MYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGML 802
++ G ++I + + + I+A++ G++++ ++ F + AA +
Sbjct: 308 IFCSYSLAVWFGGKMIIEKGYNGGNVINIIVAVLTGSMSLGQASPCLGAFAAGQAAAYKM 367
Query: 801 FNIIYRKPRTG--DLMEGDRPEIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVAL 628
I RKP D +IRG+I +V F+YP RP + I G G T AL
Sbjct: 368 LETIKRKPEIDSYDTSGHKSDDIRGDIELRDVSFTYPARPDEQIFNGFSLFIPSGTTSAL 427
Query: 627 VGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIR 448
VG SGSGKST I ++ERFYD G + IDG +++ L +R ++ LV QEP LFA +IR
Sbjct: 428 VGQSGSGKSTVISLIERFYDPQAGEVLIDGVNLKDFQLRWIRGKIGLVSQEPVLFASSIR 487
Query: 447 ENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARAL 268
+N+ G +E+I A E ANA++F+ LP G+DT VGE G QLSGGQKQRIAIARA+
Sbjct: 488 DNIAYGKDGATVEEIKAATERANASKFIDKLPQGLDTLVGEHGTQLSGGQKQRIAIARAI 547
Query: 267 VRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGK 88
++DP+ILLLDEATSALD+ESE VQEALDR RT + +AHRLS+++N+D I I +GK
Sbjct: 548 LKDPRILLLDEATSALDAESEHIVQEALDRIMVNRTTVIVAHRLSTVRNADTIAVIHRGK 607
Query: 87 VQEAGNHTQ-LMHQKGRYYKLIKKQDL 10
+ E G+H L++ G Y +LI+ Q++
Sbjct: 608 IVEKGSHLDLLLNPDGAYCQLIRLQEI 634
>gi|15217776|ref|NP_174115.1| multidrug resistance P-glycoprotein,
putative [Arabidopsis thaliana]
gi|25297458|pir||G86404 probable P-glycoprotein [imported] -
Arabidopsis thaliana
gi|12322992|gb|AAG51482.1| P-glycoprotein, putative [Arabidopsis
thaliana]
Length = 1245
Score = 651 bits (1679), Expect = 0.0
Identities = 397/1252 (31%), Positives = 646/1252 (50%), Gaps = 14/1252 (1%)
Frame = -1
Query: 3744 QQLEAQPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTS 3565
+ ++ + VS+ GLF K DY L+ +G + A I G + P+ + G++ ++L
Sbjct: 23 KNIKKESVSLMGLFSAADKLDYFLMLLGGLGACIHGATLPLFFVFFGKMLDSLGNLSTDP 82
Query: 3564 KQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFD 3385
K ++ ++N + +G+ ++ +I C+ R A++R ++ S+L ++ +FD
Sbjct: 83 KAISSRVSQNALYLVYLGLVNFVSAWIGVSCWMQTGERQTARLRINYLKSILAKDITFFD 142
Query: 3384 KN-HSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAP 3208
+ ++ +++ IGDK +LR + IA V+ ++ W+L + LGV P
Sbjct: 143 TEARDSNLIFHISSDAILVQDAIGDKTDHVLRYLSQFIAGFVIGFLSVWQLTLLTLGVVP 202
Query: 3207 TCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEK 3028
I A M++ + K AG +AEE + VRTV AF G+E+ V Y L+K
Sbjct: 203 LIAIAGGGYAIVMSTISEKSETAYADAGKVAEEVMSQVRTVYAFVGEEKAVKSYSNSLKK 262
Query: 3027 GRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGA 2848
K + Y + L++ G T F +++++
Sbjct: 263 ALKLGKRSGLAKGLGVGLTYSLLFCAWALLLWYASLLVRHGK-TNGAKAFTTILNVIFSG 321
Query: 2847 YFLGLISPHMMVLLNARVSAASIYQTI-DRVPKIDPYSKAGKRLQNVVGRVKFENVHFRY 2671
+ LG +P + + RV+AA+I++ I + + G LQNV GR++F+ V F Y
Sbjct: 322 FALGQAAPSLSAIAKGRVAAANIFRMIGNNNSESSQRLDEGTTLQNVAGRIEFQKVSFAY 381
Query: 2670 PSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVREL 2491
PSR + + L+ + G + A VG SG GKST + ++ R YEP +G + +DG D++ L
Sbjct: 382 PSRPNM-VFENLSFTIRSGKTFAFVGPSGSGKSTIISMVQRFYEPNSGEILLDGNDIKSL 440
Query: 2490 NIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYD 2311
++W R +G+V QEP LF TI +N+L+G + + +IE K ANA FI+ +P GY+
Sbjct: 441 KLKWFREQLGLVSQEPALFATTIASNILLGKENANMDQIIEAAKAANADSFIKSLPNGYN 500
Query: 2310 TLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRT 2131
T +G+GG QLSGGQKQR+AIAR ++R+PK+LLLDEATSALDA+SE IVQ AL+N + RT
Sbjct: 501 TQVGEGGTQLSGGQKQRIAIARAVLRNPKILLLDEATSALDAESEKIVQQALDNVMEKRT 560
Query: 2130 TIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKADPXXXXXX 1951
TI++AHRLSTIR DKIV G + E G+H EL+ GG Y LV Q+ +
Sbjct: 561 TIVVAHRLSTIRNVDKIVVLRDGQVRETGSHSELMLRGGDYATLVNCQETEPQENSRSI- 619
Query: 1950 XXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXXXXXXXXXXX 1771
+ +T + G+S + S S+R+
Sbjct: 620 ------MSETCKS----------------QAGSSSSRRVSSSRRT---SSFRVDQEKTKN 654
Query: 1770 XXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPY 1591
+D ++ ++ K + Y LG++ A++ G + P ++ +V F + P+
Sbjct: 655 DDSKKDFSSSSMIWELIKLNSPEWPYALLGSIGAVLAGAQTPLFSMGIAYVLTAF-YSPF 713
Query: 1590 GGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYF 1411
+ + I FA G+ L + ++ E L+ R R+ F +L + +F
Sbjct: 714 PNVIKRDVEKVAIIFAGAGIVTAPIYLLQHYFYTLMGERLTSRVRLSLFSAILSNEIGWF 773
Query: 1410 DNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXX 1231
D + G L + LA+DA +++ + R+ + Y W+
Sbjct: 774 DLDENNTGSLTSILAADATLVRSALADRLSTIVQNLSLTVTALALAFFYSWR-----VAA 828
Query: 1230 XXXLAFVMIGLAYKISLMNVEQIQND------DAGRIAIEIIENVKTIQLLTRCELFFDH 1069
F ++ A + ++ D A +A E I N++T+ + +
Sbjct: 829 VVTACFPLLIAASLTEQLFLKGFGGDYTRAYSRATSVAREAIANIRTVAAYGAEKQISEQ 888
Query: 1068 YQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGI----RIIYQGDKSSDDTF 901
+ + ++ +G I Y L+Q F+ +YA+G+ +I + + D+
Sbjct: 889 FTCELSKPTKNAFVRGHISGFGYGLSQ----FLAFCSYALGLWYVSVLINHKETNFGDSI 944
Query: 900 KGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLMEGDR--PEIRGNI 727
K + +++ A +V + P+ VK A G +F +++R+ + R +++G+I
Sbjct: 945 KSFMVLIVTAFSVSETLALTPDIVKGTQALGSVFRVLHRETKISPDQPNSRMVSQVKGDI 1004
Query: 726 LFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALR 547
F NV F YP RP I K L G+++A+VGPSGSGKST IG++ RFYD + G L
Sbjct: 1005 EFRNVSFVYPTRPEIDIFKNLNLRVSAGKSLAVVGPSGSGKSTVIGLIMRFYDPSNGNLC 1064
Query: 546 IDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGLKDVPLEKINQALELANANRF 367
IDGQDI+ L+L LR ++ALV QEP LF+ TI EN+ G ++ +I +A + ANA+ F
Sbjct: 1065 IDGQDIKTLNLRSLRKKLALVQQEPALFSTTIYENIKYGNENASEAEIMEAAKAANAHEF 1124
Query: 366 LANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEA 187
+ + G T G+KG QLSGGQKQR+AIARA+++DP +LLLDEATSALD+ SE+ VQEA
Sbjct: 1125 IIKMEEGYKTHAGDKGVQLSGGQKQRVAIARAVLKDPSVLLLDEATSALDTSSEKLVQEA 1184
Query: 186 LDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYK 31
LD+ +GRT + +AHRLS+I+ +D + + KG+V E G+H +L+ +YK
Sbjct: 1185 LDKLMKGRTTVLVAHRLSTIRKADTVAVLHKGRVVEKGSHRELVSIPNGFYK 1236
Score = 342 bits (876), Expect = 6e-92
Identities = 197/570 (34%), Positives = 310/570 (53%), Gaps = 9/570 (1%)
Frame = -1
Query: 3666 IGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKANENVYIFLGIGIFISITNF 3487
+G+I A+++G P+ ++ V A Y P + + IF G GI +
Sbjct: 683 LGSIGAVLAGAQTPLFSMGIAYVLTAF--YSPFPNVIKRDVEKVAIIFAGAGIVTAPIYL 740
Query: 3486 IQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFD--KNHSGTITTKLNDSMERIREGIGD 3313
+Q+ + R+ +++R ++L GWFD +N++G++T+ L +R + D
Sbjct: 741 LQHYFYTLMGERLTSRVRLSLFSAILSNEIGWFDLDENNTGSLTSILAADATLVRSALAD 800
Query: 3312 KLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIG-- 3139
+L +++ ++ + A+ +A+ Y WR+A+++ P L+A +T + G
Sbjct: 801 RLSTIVQNLSLTVTALALAFFYSWRVAAVVTACFPL------LIAASLTEQLFLKGFGGD 854
Query: 3138 ----VGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXX 2971
+A S+A E++ +RTV A+ ++++ ++ EL K K A +
Sbjct: 855 YTRAYSRATSVAREAIANIRTVAAYGAEKQISEQFTCELSKPTKNAFVRGHISGFGYGLS 914
Query: 2970 XXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVS 2791
G+ Y + L+ T GD M +++ A+ + ++ +
Sbjct: 915 QFLAFCSYALGLWYVSVLINHKE-TNFGDSIKSFMVLIVTAFSVSETLALTPDIVKGTQA 973
Query: 2790 AASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGT 2611
S+++ + R KI P + + V G ++F NV F YP+R + I LNL V G
Sbjct: 974 LGSVFRVLHRETKISPDQPNSRMVSQVKGDIEFRNVSFVYPTRPEIDIFKNLNLRVSAGK 1033
Query: 2610 SVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFN 2431
S+A+VG SG GKST +GL+ R Y+P GN+ IDG D++ LN+ LR + +VQQEP LF+
Sbjct: 1034 SLAVVGPSGSGKSTVIGLIMRFYDPSNGNLCIDGQDIKTLNLRSLRKKLALVQQEPALFS 1093
Query: 2430 DTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAI 2251
TI+ N+ GN ++ ++E K ANAH+FI KM +GY T GD GVQLSGGQKQRVAI
Sbjct: 1094 TTIYENIKYGNENASEAEIMEAAKAANAHEFIIKMEEGYKTHAGDKGVQLSGGQKQRVAI 1153
Query: 2250 ARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFF 2071
AR +++DP VLLLDEATSALD SE +VQ AL+ KGRTT+++AHRLSTIR+AD +
Sbjct: 1154 ARAVLKDPSVLLLDEATSALDTSSEKLVQEALDKLMKGRTTVLVAHRLSTIRKADTVAVL 1213
Query: 2070 EKGVIVEAGNHEELVRL-GGRYFDLVKAQQ 1984
KG +VE G+H ELV + G Y L Q+
Sbjct: 1214 HKGRVVEKGSHRELVSIPNGFYKQLTSLQE 1243
Score = 297 bits (761), Expect = 1e-78
Identities = 191/571 (33%), Positives = 297/571 (51%), Gaps = 5/571 (0%)
Frame = -1
Query: 1710 KGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGRMMH-RMAMAVIAFASVG 1534
K +Y M LG + A I G LP + FG + + + + + R++ + +G
Sbjct: 41 KLDYFLMLLGGLGACIHGATLPLFFVFFGKMLDSLGNLSTDPKAISSRVSQNALYLVYLG 100
Query: 1533 VGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAP 1354
+ + S + E + R R+ +++L +D ++FD A LI ++SDA
Sbjct: 101 LVNFVSAWIGVSCWMQTGERQTARLRINYLKSILAKDITFFDTEAR-DSNLIFHISSDAI 159
Query: 1353 NIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMN 1174
++ + + V + WQ +A G A +S ++
Sbjct: 160 LVQDAIGDKTDHVLRYLSQFIAGFVIGFLSVWQLTLLTLGVVPLIAIAGGGYAIVMSTIS 219
Query: 1173 VE-QIQNDDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYS 997
+ + DAG++A E++ V+T+ E Y S K+ + + G+ + +
Sbjct: 220 EKSETAYADAGKVAEEVMSQVRTVYAFVGEEKAVKSYSNSLKKALKLGKRSGLAKGLGVG 279
Query: 996 LTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKT 817
LT S ++ ++ G + F I+ ++ A+ +A K +
Sbjct: 280 LTYSLLFCAWALLLWYASLLVRHGKTNGAKAFTTILNVIFSGFALGQAAPSLSAIAKGRV 339
Query: 816 AAGMLFNIIYRKPRTGD--LMEGDRPE-IRGNILFENVKFSYPQRPLQPIMKGLQWTALR 646
AA +F +I L EG + + G I F+ V F+YP RP + + L +T
Sbjct: 340 AAANIFRMIGNNNSESSQRLDEGTTLQNVAGRIEFQKVSFAYPSRP-NMVFENLSFTIRS 398
Query: 645 GQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRL 466
G+T A VGPSGSGKST I M++RFY+ G + +DG DI+ L L R Q+ LV QEP L
Sbjct: 399 GKTFAFVGPSGSGKSTIISMVQRFYEPNSGEILLDGNDIKSLKLKWFREQLGLVSQEPAL 458
Query: 465 FAGTIRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRI 286
FA TI N+ LG ++ +++I +A + ANA+ F+ +LP G +T VGE G QLSGGQKQRI
Sbjct: 459 FATTIASNILLGKENANMDQIIEAAKAANADSFIKSLPNGYNTQVGEGGTQLSGGQKQRI 518
Query: 285 AIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIV 106
AIARA++R+PKILLLDEATSALD+ESE+ VQ+ALD E RT I +AHRLS+I+N D IV
Sbjct: 519 AIARAVLRNPKILLLDEATSALDAESEKIVQQALDNVMEKRTTIVVAHRLSTIRNVDKIV 578
Query: 105 YIDKGKVQEAGNHTQLMHQKGRYYKLIKKQD 13
+ G+V+E G+H++LM + G Y L+ Q+
Sbjct: 579 VLRDGQVRETGSHSELMLRGGDYATLVNCQE 609
>gi|27368865|emb|CAD59590.1| MDR-like ABC transporter [Oryza sativa
(japonica cultivar-group)]
gi|46485796|gb|AAS98421.1| MDR-like ABC transporter [Oryza sativa
(japonica cultivar-group)]
Length = 1276
Score = 650 bits (1678), Expect = 0.0
Identities = 404/1247 (32%), Positives = 655/1247 (52%), Gaps = 14/1247 (1%)
Frame = -1
Query: 3723 VSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKA 3544
V+ LF + D L+ +GT+ A+ +G + P + ++ G + +A +
Sbjct: 39 VAFHRLFAFADGTDAALMLLGTLGAVANGAALPFMTVLFGGLIDAF--GGAAGGDVVARV 96
Query: 3543 NENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFDKN-HSGT 3367
+E F+ + + + +FIQ C+ R A++R ++ ++LRQ +FDK+ ++G
Sbjct: 97 SEVSLQFIYLAVASAAASFIQVACWMITGERQAARIRSLYLRTILRQEVAFFDKHTNTGE 156
Query: 3366 ITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMS 3187
+ +++ I++ +G+K+G ++ + VA+ W L +ML P + +
Sbjct: 157 VVGRMSGDTVLIQDAMGEKVGKFVQLLVTFLGGFGVAFAQGWLLTLVMLATIPPLVLSGA 216
Query: 3186 LLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVW 3007
+++ + A + E+++ +RTV +F G+++ V +Y L++ V
Sbjct: 217 VMSNVVARMASLGQAAYADASVVVEQTIGSIRTVASFTGEKQAVAKYSRSLKRAYSSGVR 276
Query: 3006 KXXXXXXXXXXXXXXXXXXXGCGMLYGAYL-LKVGIITTPGDVFIVVMSMLLGAYFLGLI 2830
+ G+ YGA L L+ G T V V+ ++L G+ LG
Sbjct: 277 EGLAAGVGMGTVMVLLFCGYSLGIWYGAKLILEKGY--TGAQVMNVIFAVLTGSLALGQA 334
Query: 2829 SPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAK 2650
SP M + +A +++TI+R P+ID YS G++L ++ G ++F NV+F YP+R D +
Sbjct: 335 SPSMKAFAGGQAAAYKMFETINREPEIDAYSATGRKLDDIQGDIEFRNVYFSYPTRPDEQ 394
Query: 2649 ILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRN 2470
I G +L ++ GT+VALVG SG GKST + L+ R Y+P+ G V IDG +++EL + W+R+
Sbjct: 395 IFRGFSLAIQSGTTVALVGQSGSGKSTVISLIERFYDPQLGEVLIDGVNLKELQLRWIRS 454
Query: 2469 TVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYDTLIGDGG 2290
+G+V QEPILF +I +N+ G +T + + ++ANA FI+KMP+G+ TL+G+ G
Sbjct: 455 KIGLVSQEPILFAASIIDNIAYGRDNATNQEIRAAAELANASKFIDKMPQGFATLVGEHG 514
Query: 2289 VQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHR 2110
QLSGGQKQR+AIAR +++DP++LLLDEATSALD +SE IVQ AL+ RTT+++AHR
Sbjct: 515 TQLSGGQKQRIAIARAILKDPRILLLDEATSALDTESERIVQEALDRVMSNRTTVIVAHR 574
Query: 2109 LSTIREADKIVFFEKGVIVEAGNHEELVR-LGGRYFDLVKAQQFKADPXXXXXXXXXEID 1933
L+T+R AD I +G IVE G+H EL+ G Y L++ Q+ D
Sbjct: 575 LTTVRNADTIAVIHQGSIVEKGSHHELISDPDGAYSQLIRLQENSHDSEDANYQNKSGKK 634
Query: 1932 LDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXXXXXXXXXXXXXXXED 1753
D + R NS N SFS S
Sbjct: 635 SD--SGIRSGKQSFSYQSTPQRSSRDNSNNHSFS---VSATPLEIDVQGGSPKKIAEETP 689
Query: 1752 GQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGRMMH 1573
++ L K + LG+V + + G+ P A++ V + F P +++
Sbjct: 690 QEVPLSRLAALN--KPEIPVLLLGSVASAVSGVIFPIFAILLSNVIKAFYEPP---QVLK 744
Query: 1572 RMAMAVIAFASVGVGVWFSQL-ASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAH 1396
+ A + V V+F L S LF+V L R R+ +F ++ + +FD+P +
Sbjct: 745 KDAEFWSSMFLVFGAVYFLSLPIGSYLFSVAGCRLIRRIRLMTFEKVVNMEIEWFDHPEN 804
Query: 1395 APGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLA 1216
+ G + RL++DA I+ +V + V I W+
Sbjct: 805 SSGSIGARLSADAAKIRGLVGDALQLVVQNLATLVAGLLIAFISNWE-----LSLIILAL 859
Query: 1215 FVMIGLAYKISLMNVE------QIQNDDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSS 1054
+IG+ I + ++ ++ ++A ++A + + +++T+ + E D Y+
Sbjct: 860 IPLIGVNGWIQMKFIQGFSADAKMMYEEASQVANDAVSSIRTVASFSAEEKVMDLYKMKC 919
Query: 1053 KQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLG 874
+ R+ ++ +I I + ++ ++ + ++ G R++ + + F+ +A+ +
Sbjct: 920 EGPLRTGIRTAIISGIGFGVSIFLLFGVYAASFYAGARLVEDRKTTFPNVFRVFLALTMA 979
Query: 873 AVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPR--TGDLMEGDRPEIRGNILFENVKFSY 700
A+ V +++ + KAK+A +F I+ RK R D +RG+I F++V F Y
Sbjct: 980 AIGVSHTSNLTSDSSKAKSAVSSIFAIVDRKSRIDPSDDAGVSLEPLRGDIEFQHVSFRY 1039
Query: 699 PQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKL 520
P RP I + L T G+TVALVG SGSGKST I +L+RFYD G + +DG DI+K
Sbjct: 1040 PTRPDVQIFEDLCLTIQSGKTVALVGESGSGKSTAISLLQRFYDPDAGHILLDGVDIQKF 1099
Query: 519 SLFHLRTQMALVGQEPRLFAGTIRENVCLGLK-DVPLEKINQALELANANRFLANLPAGI 343
L LR QM LV QEP LF TIR N+ G + D I + +LANA++F+++L G
Sbjct: 1100 QLRWLRQQMGLVSQEPALFNDTIRANIAYGKEGDATESDIVSSAQLANAHKFISSLHQGY 1159
Query: 342 DTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGR 163
+T VGE+G QLSGGQKQRIAIARA+V+DPKILLLDEATSALD+ESER VQ+ALDR R
Sbjct: 1160 ETMVGERGAQLSGGQKQRIAIARAIVKDPKILLLDEATSALDAESERVVQDALDRVMMNR 1219
Query: 162 TCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQK-GRYYKLI 25
T + +AHRLS+IQ +D+I + G + E G H L+ K G Y L+
Sbjct: 1220 TTVIVAHRLSTIQGADMIAVVKNGMIIEKGKHDALIGIKDGAYASLV 1266
Score = 289 bits (739), Expect = 4e-76
Identities = 183/564 (32%), Positives = 296/564 (52%), Gaps = 4/564 (0%)
Frame = -1
Query: 1692 MFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQ 1513
M LGT+ A+ G LP + ++FG + + F GG ++ R++ + F + V +
Sbjct: 56 MLLGTLGAVANGAALPFMTVLFGGLIDAFGGAA-GGDVVARVSEVSLQFIYLAVASAAAS 114
Query: 1512 LASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVD 1333
+ + E + R R R +L Q+ ++FD + G+++ R++ D I+ +
Sbjct: 115 FIQVACWMITGERQAARIRSLYLRTILRQEVAFFDKHTNT-GEVVGRMSGDTVLIQDAMG 173
Query: 1332 ARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLM-NVEQIQN 1156
++ + W L ++ ++ M ++ Q
Sbjct: 174 EKVGKFVQLLVTFLGGFGVAFAQGWLLTLVMLATIPPLVLSGAVMSNVVARMASLGQAAY 233
Query: 1155 DDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMY 976
DA + + I +++T+ T + Y S K+ S +++G+ + ++
Sbjct: 234 ADASVVVEQTIGSIRTVASFTGEKQAVAKYSRSLKRAYSSGVREGLAAGVGMGTVMVLLF 293
Query: 975 FMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFN 796
G ++I + + I A++ G++A+ ++ F + AA +F
Sbjct: 294 CGYSLGIWYGAKLILEKGYTGAQVMNVIFAVLTGSLALGQASPSMKAFAGGQAAAYKMFE 353
Query: 795 IIYRKPRTGDLMEGDRP--EIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVG 622
I R+P R +I+G+I F NV FSYP RP + I +G G TVALVG
Sbjct: 354 TINREPEIDAYSATGRKLDDIQGDIEFRNVYFSYPTRPDEQIFRGFSLAIQSGTTVALVG 413
Query: 621 PSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIREN 442
SGSGKST I ++ERFYD G + IDG ++++L L +R+++ LV QEP LFA +I +N
Sbjct: 414 QSGSGKSTVISLIERFYDPQLGEVLIDGVNLKELQLRWIRSKIGLVSQEPILFAASIIDN 473
Query: 441 VCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVR 262
+ G + ++I A ELANA++F+ +P G T VGE G QLSGGQKQRIAIARA+++
Sbjct: 474 IAYGRDNATNQEIRAAAELANASKFIDKMPQGFATLVGEHGTQLSGGQKQRIAIARAILK 533
Query: 261 DPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQ 82
DP+ILLLDEATSALD+ESER VQEALDR RT + +AHRL++++N+D I I +G +
Sbjct: 534 DPRILLLDEATSALDTESERIVQEALDRVMSNRTTVIVAHRLTTVRNADTIAVIHQGSIV 593
Query: 81 EAGNHTQLMHQ-KGRYYKLIKKQD 13
E G+H +L+ G Y +LI+ Q+
Sbjct: 594 EKGSHHELISDPDGAYSQLIRLQE 617
>gi|15217785|ref|NP_171753.1| multidrug resistance P-glycoprotein,
putative [Arabidopsis thaliana]
gi|25297455|pir||E86155 probable ABC transporter [imported] -
Arabidopsis thaliana
gi|9972378|gb|AAG10628.1| Putative ABC transporter [Arabidopsis
thaliana]
Length = 1278
Score = 649 bits (1675), Expect = 0.0
Identities = 401/1259 (31%), Positives = 656/1259 (51%), Gaps = 25/1259 (1%)
Frame = -1
Query: 3735 EAQPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQF 3556
+A V LF + D LL+ G+I AI +G+S P + L+ G + ++ K
Sbjct: 37 KANTVPFYKLFAFADSSDVLLMICGSIGAIGNGMSLPFMTLLFGDLIDSF------GKNQ 90
Query: 3555 RNKANENV-------YIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNA 3397
NK +V +++LG+G + F+Q C+ R A++R ++ ++LRQ+
Sbjct: 91 NNKDIVDVVSKVCLKFVYLGLGTLGAA--FLQVACWMITGERQAARIRSTYLKTILRQDI 148
Query: 3396 GWFD-KNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMML 3220
G+FD + ++G + +++ I++ +G+K+G ++ + + V+A+I W L +ML
Sbjct: 149 GFFDVETNTGEVVGRMSGDTVLIQDAMGEKVGKFIQLVSTFVGGFVLAFIKGWLLTLVML 208
Query: 3219 GVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEA 3040
P + + +A +T + + KA ++ E+++ +RTV +F G+++ + Y+
Sbjct: 209 TSIPLLAMAGAAMALIVTRASSRGQAAYAKAATVVEQTIGSIRTVASFTGEKQAINSYKK 268
Query: 3039 ELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGA-YLLKVGIITTPGDVFIVVMS 2863
+ K ++ + + +G +L+ G T G V V++
Sbjct: 269 FITSAYKSSIQQGFSTGLGLGVMFFVFFSSYALAIWFGGKMILEKGY--TGGAVINVIII 326
Query: 2862 MLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENV 2683
++ G+ LG SP + + +A +++TI R P ID Y GK L+++ G ++ ++V
Sbjct: 327 VVAGSMSLGQTSPCVTAFAAGQAAAYKMFETIKRKPLIDAYDVNGKVLEDIRGDIELKDV 386
Query: 2682 HFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTD 2503
HF YP+R D +I +G +L + G + ALVG SG GKST + L+ R Y+P++G V IDG +
Sbjct: 387 HFSYPARPDEEIFDGFSLFIPSGATAALVGESGSGKSTVISLIERFYDPKSGAVLIDGVN 446
Query: 2502 VRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMP 2323
++E ++W+R+ +G+V QEP+LF+ +I N+ G +T E + ++ANA FI+K+P
Sbjct: 447 LKEFQLKWIRSKIGLVSQEPVLFSSSIMENIAYGKENATVEEIKAATELANAAKFIDKLP 506
Query: 2322 KGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNAS 2143
+G DT++G+ G QLSGGQKQR+AIAR +++DP++LLLDEATSALDA+SE +VQ AL+
Sbjct: 507 QGLDTMVGEHGTQLSGGQKQRIAIARAILKDPRILLLDEATSALDAESERVVQEALDRVM 566
Query: 2142 KGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVR-LGGRYFDLVKAQQFKADPX 1966
RTT+++AHRLST+R AD I +G +VE G+H EL++ G Y L++ Q+ D
Sbjct: 567 VNRTTVIVAHRLSTVRNADMIAVIHRGKMVEKGSHSELLKDSEGAYSQLIRLQEINKDVK 626
Query: 1965 XXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXXXXXX 1786
+ R +SLN G
Sbjct: 627 TSELSSGSSFRNSNLKKSMEGTSSVGNSS------RHHSLN--VLGLTTGLDLGSHSQRA 678
Query: 1785 XXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGF 1606
++ I K + LGTV A I G P ++ V E F
Sbjct: 679 GQDETGTASQEPLPKVSLTRIAALNKPEIPVLLLGTVAAAINGAIFPLFGILISRVIEAF 738
Query: 1605 TFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQ 1426
F P + I F ++GV LFAV L R R F ++
Sbjct: 739 -FKP-AHELKRDSRFWAIIFVALGVTSLIVSPTQMYLFAVAGGKLIRRIRSMCFEKAVHM 796
Query: 1425 DASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXX 1246
+ ++FD P ++ G + RL++DA I+A+V + W+
Sbjct: 797 EVAWFDEPQNSSGTMGARLSADATLIRALVGDALSLAVQNVASAASGLIIAFTASWE--- 853
Query: 1245 XXXXXXXXLAFVMIGLAYKISLMNVEQIQND------DAGRIAIEIIENVKTIQLLTRCE 1084
+ +IG+ + + ++ D +A ++A + + +++T+ E
Sbjct: 854 --LALIILVMLPLIGINGFVQVKFMKGFSADAKSKYEEASQVANDAVGSIRTVASFCAEE 911
Query: 1083 LFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDT 904
Y+ + + +K+G I + + + ++ + ++ G R++ G + ++
Sbjct: 912 KVMQMYKKQCEGPIKDGIKQGFISGLGFGFSFFILFCVYATSFYAGARLVEDGKTTFNNV 971
Query: 903 FKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPR------TGDLMEGDRPE 742
F+ A+ + A+ + S+ + P+ KAK AA +F II RK + TG ++E
Sbjct: 972 FQVFFALTMAAIGISQSSTFAPDSSKAKVAAASIFAIIDRKSKIDSSDETGTVLE----N 1027
Query: 741 IRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVT 562
++G+I ++ F+YP RP I + L T G+TVALVG SGSGKST I +L+RFYD
Sbjct: 1028 VKGDIELRHLSFTYPARPDIQIFRDLCLTIRAGKTVALVGESGSGKSTVISLLQRFYDPD 1087
Query: 561 GGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGL---KDVPLEKINQAL 391
G + +DG +++KL L LR QM LVGQEP LF TIR N+ G + +I A
Sbjct: 1088 SGHITLDGVELKKLQLKWLRQQMGLVGQEPVLFNDTIRANIAYGKGSEEAATESEIIAAA 1147
Query: 390 ELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSE 211
ELANA++F++++ G DT VGE+G QLSGGQKQR+AIARA+V++PKILLLDEATSALD+E
Sbjct: 1148 ELANAHKFISSIQQGYDTVVGERGIQLSGGQKQRVAIARAIVKEPKILLLDEATSALDAE 1207
Query: 210 SERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYY 34
SER VQ+ALDR RT I +AHRLS+I+N+D+I + G + E G H L+ +G Y
Sbjct: 1208 SERVVQDALDRVMVNRTTIVVAHRLSTIKNADVIAVVKNGVIAEKGTHETLIKIEGGVY 1266
Score = 342 bits (878), Expect = 3e-92
Identities = 198/567 (34%), Positives = 316/567 (54%), Gaps = 6/567 (1%)
Frame = -1
Query: 3675 LLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKANENVYIFLGIGIFISI 3496
+L +GT+ A I+G P+ ++ RV A + + + + IF+ +G+ I
Sbjct: 709 VLLLGTVAAAINGAIFPLFGILISRVIEAFF---KPAHELKRDSRFWAIIFVALGVTSLI 765
Query: 3495 TNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFDK--NHSGTITTKLNDSMERIREG 3322
+ Q F +++ ++R + WFD+ N SGT+ +L+ IR
Sbjct: 766 VSPTQMYLFAVAGGKLIRRIRSMCFEKAVHMEVAWFDEPQNSSGTMGARLSADATLIRAL 825
Query: 3321 IGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELI 3142
+GD L + ++ A + +++A+ W LA ++L + P I + + M +
Sbjct: 826 VGDALSLAVQNVASAASGLIIAFTASWELALIILVMLPLIGINGFVQVKFMKGFSADAKS 885
Query: 3141 GVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXX 2962
+A +A +++ +RTV +F +E+++ Y+ + E K + +
Sbjct: 886 KYEEASQVANDAVGSIRTVASFCAEEKVMQMYKKQCEGPIKDGIKQGFISGLGFGFSFFI 945
Query: 2961 XXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAAS 2782
GA L++ G TT +VF V ++ + A + S A+V+AAS
Sbjct: 946 LFCVYATSFYAGARLVEDGK-TTFNNVFQVFFALTMAAIGISQSSTFAPDSSKAKVAAAS 1004
Query: 2781 IYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVA 2602
I+ IDR KID + G L+NV G ++ ++ F YP+R D +I L L + G +VA
Sbjct: 1005 IFAIIDRKSKIDSSDETGTVLENVKGDIELRHLSFTYPARPDIQIFRDLCLTIRAGKTVA 1064
Query: 2601 LVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTI 2422
LVG SG GKST + LL R Y+P++G++T+DG ++++L ++WLR +G+V QEP+LFNDTI
Sbjct: 1065 LVGESGSGKSTVISLLQRFYDPDSGHITLDGVELKKLQLKWLRQQMGLVGQEPVLFNDTI 1124
Query: 2421 HNNLLIGN---PGSTRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAI 2251
N+ G +T +I ++ANAH FI + +GYDT++G+ G+QLSGGQKQRVAI
Sbjct: 1125 RANIAYGKGSEEAATESEIIAAAELANAHKFISSIQQGYDTVVGERGIQLSGGQKQRVAI 1184
Query: 2250 ARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFF 2071
AR ++++PK+LLLDEATSALDA+SE +VQ AL+ RTTI++AHRLSTI+ AD I
Sbjct: 1185 ARAIVKEPKILLLDEATSALDAESERVVQDALDRVMVNRTTIVVAHRLSTIKNADVIAVV 1244
Query: 2070 EKGVIVEAGNHEELVRL-GGRYFDLVK 1993
+ GVI E G HE L+++ GG Y LV+
Sbjct: 1245 KNGVIAEKGTHETLIKIEGGVYASLVQ 1271
Score = 296 bits (757), Expect = 4e-78
Identities = 188/575 (32%), Positives = 309/575 (53%), Gaps = 12/575 (2%)
Frame = -1
Query: 1698 LYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWF 1519
L M G++ A+ G+ LP + L+FG + + F ++ ++ + F +G+G
Sbjct: 56 LLMICGSIGAIGNGMSLPFMTLLFGDLIDSFGKNQNNKDIVDVVSKVCLKFVYLGLGTLG 115
Query: 1518 SQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAV 1339
+ + + E + R R + +L QD +FD + G+++ R++ D I+
Sbjct: 116 AAFLQVACWMITGERQAARIRSTYLKTILRQDIGFFDVETNT-GEVVGRMSGDTVLIQDA 174
Query: 1338 VDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVE-QI 1162
+ ++ + I W LA +A ++ + Q
Sbjct: 175 MGEKVGKFIQLVSTFVGGFVLAFIKGWLLTLVMLTSIPLLAMAGAAMALIVTRASSRGQA 234
Query: 1161 QNDDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSF 982
A + + I +++T+ T + + Y+ +S +++G + +
Sbjct: 235 AYAKAATVVEQTIGSIRTVASFTGEKQAINSYKKFITSAYKSSIQQGFSTGLGLGV---- 290
Query: 981 MYFMMCFTYAVGI----RIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTA 814
M+F+ +YA+ I ++I + + II ++ G++++ ++ F + A
Sbjct: 291 MFFVFFSSYALAIWFGGKMILEKGYTGGAVINVIIIVVAGSMSLGQTSPCVTAFAAGQAA 350
Query: 813 AGMLFNIIYRKPR------TGDLMEGDRPEIRGNILFENVKFSYPQRPLQPIMKGLQWTA 652
A +F I RKP G ++E +IRG+I ++V FSYP RP + I G
Sbjct: 351 AYKMFETIKRKPLIDAYDVNGKVLE----DIRGDIELKDVHFSYPARPDEEIFDGFSLFI 406
Query: 651 LRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEP 472
G T ALVG SGSGKST I ++ERFYD GA+ IDG ++++ L +R+++ LV QEP
Sbjct: 407 PSGATAALVGESGSGKSTVISLIERFYDPKSGAVLIDGVNLKEFQLKWIRSKIGLVSQEP 466
Query: 471 RLFAGTIRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQ 292
LF+ +I EN+ G ++ +E+I A ELANA +F+ LP G+DT VGE G QLSGGQKQ
Sbjct: 467 VLFSSSIMENIAYGKENATVEEIKAATELANAAKFIDKLPQGLDTMVGEHGTQLSGGQKQ 526
Query: 291 RIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDL 112
RIAIARA+++DP+ILLLDEATSALD+ESER VQEALDR RT + +AHRLS+++N+D+
Sbjct: 527 RIAIARAILKDPRILLLDEATSALDAESERVVQEALDRVMVNRTTVIVAHRLSTVRNADM 586
Query: 111 IVYIDKGKVQEAGNHTQLM-HQKGRYYKLIKKQDL 10
I I +GK+ E G+H++L+ +G Y +LI+ Q++
Sbjct: 587 IAVIHRGKMVEKGSHSELLKDSEGAYSQLIRLQEI 621
>gi|15234323|ref|NP_192092.1| multidrug resistance P-glycoprotein,
putative [Arabidopsis thaliana]
gi|25297454|pir||E85023 probable P-glycoprotein-like protein
[imported] - Arabidopsis thaliana
gi|4558552|gb|AAD22645.1| putative P-glycoprotein-like protein
[Arabidopsis thaliana]
gi|7268567|emb|CAB80676.1| putative P-glycoprotein-like protein
[Arabidopsis thaliana]
Length = 1230
Score = 647 bits (1670), Expect = 0.0
Identities = 401/1262 (31%), Positives = 665/1262 (51%), Gaps = 27/1262 (2%)
Frame = -1
Query: 3738 LEAQPVSIP--GLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTS 3565
LEA ++P LF + D LL+ +G+I AI +GV P++ L+ G + +A+
Sbjct: 6 LEANTKTVPFYKLFFFSDSTDVLLMIVGSIGAIANGVCSPLMTLLFGELIDAM------- 58
Query: 3564 KQFRNKANENVY----------IFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYS 3415
N+ NE + ++LG+G + F+Q C+ R A++R ++ +
Sbjct: 59 --GPNQNNEEIVERVSKVCLSLVYLGLGALGAA--FLQVACWMITGERQAARIRSLYLKT 114
Query: 3414 VLRQNAGWFD-KNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWR 3238
+LRQ+ G+FD + +G + +++ I + +G+K+G ++ + + V+A++ W
Sbjct: 115 ILRQDIGFFDVEMTTGEVVGRMSGDTVLILDAMGEKVGKFIQLISTFVGGFVIAFLRGWL 174
Query: 3237 LASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEM 3058
L +ML P + + +A +T + +E KA ++ E++L +RTV +F G+++
Sbjct: 175 LTLVMLTSIPLLAMSGAAIAIIVTRASSQEQAAYAKASNVVEQTLGSIRTVASFTGEKQA 234
Query: 3057 VGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGA-YLLKVGIITTPGDV 2881
+ Y+ + K V + G +G +L+ G T G V
Sbjct: 235 MSSYKELINLAYKSNVKQGFVTGLGLGVMFLVFFSTYALGTWFGGEMILRKGY--TGGAV 292
Query: 2880 FIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGR 2701
V+++++ + LG SP + + +A +++TI+R P ID + GK L+++ G
Sbjct: 293 INVMVTVVSSSIALGQASPCLTAFTAGKAAAYKMFETIEREPLIDTFDLNGKVLEDIRGE 352
Query: 2700 VKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNV 2521
++ +V F YP+R ++ G +L++ GT+ ALVG SG GKST + L+ R Y+P +G V
Sbjct: 353 IELRDVCFSYPARPKEEVFGGFSLLIPSGTTTALVGESGSGKSTVISLIERFYDPNSGQV 412
Query: 2520 TIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHD 2341
IDG D++E ++W+R +G+V QEP+LF+ +I N+ G G+T E + K+ANA
Sbjct: 413 LIDGVDLKEFQLKWIRGKIGLVSQEPVLFSSSIMENIGYGKEGATVEEIQAASKLANAAK 472
Query: 2340 FIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQS 2161
FI+K+P G +TL+G+ G QLSGGQKQR+AIAR +++DP++LLLDEATSALDA+SE +VQ
Sbjct: 473 FIDKLPLGLETLVGEHGTQLSGGQKQRIAIARAILKDPRILLLDEATSALDAESERVVQE 532
Query: 2160 ALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVR-LGGRYFDLVKAQQ 1984
AL+ RTT+++AHRLST+R AD I +G IVE G+H EL++ G Y L++ Q+
Sbjct: 533 ALDRIMVNRTTVIVAHRLSTVRNADIIAVIHRGKIVEEGSHSELLKDHEGAYSQLLRLQE 592
Query: 1983 FKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXX 1804
+ +++ D RGN + +++
Sbjct: 593 INKE--------SKRLEISDGSISSGSS-------------RGN------NSTRQDDDSF 625
Query: 1803 XXXXXXXXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFG 1624
++ + I K + LGT+ + G P ++F
Sbjct: 626 SVLGLLAGQDSTKMSQELSQKVSFTRIAALNKPEIPILILGTLVGAVNGTIFPIFGILFA 685
Query: 1623 WVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSF 1444
V E F P+ + R + F +GV ++ LFA+ L R R F
Sbjct: 686 KVIEAFFKAPHELKRDSRFWSMI--FVLLGVAAVIVYPTTNYLFAIAGGRLIRRIRSMCF 743
Query: 1443 RNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIY 1264
+++ + +FD P ++ G + RL++DA I+ +V +
Sbjct: 744 EKVVHMEVGWFDEPGNSSGAMGARLSADAALIRTLVGDSLCLSVKNVASLVTGLIIAFTA 803
Query: 1263 CWQXXXXXXXXXXXLAFVMIGLAYKISLMN----VEQIQNDDAGRIAIEIIENVKTIQLL 1096
W+ + F+ I +I M + + ++A ++A + + +++T+
Sbjct: 804 SWE---VAIIILVIIPFIGINGYIQIKFMKGFSADAKAKYEEASQVANDAVGSIRTVASF 860
Query: 1095 TRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKS 916
E + Y+ + +S +K+G+I + + ++ +Y + + VG R++ G +
Sbjct: 861 CAEEKVMEMYKKRCEDTIKSGIKQGLISGVGFGISFFVLYSVYASCFYVGARLVKAGRTN 920
Query: 915 SDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYR------KPRTGDLMEG 754
+D F+ +A+ L AV + ++ + P+ K K AA +F II R + +G ++E
Sbjct: 921 FNDVFQVFLALTLTAVGISQASSFAPDSSKGKGAAVSIFRIIDRISKIDSRDESGMVLE- 979
Query: 753 DRPEIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERF 574
++G+I ++ F+Y RP + + L + GQTVALVG SGSGKST I +L+RF
Sbjct: 980 ---NVKGDIELCHISFTYQTRPDVQVFRDLCLSIRAGQTVALVGESGSGKSTVISLLQRF 1036
Query: 573 YDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGL--KDVPLEKIN 400
YD G + +DG +++KL L LR QM LVGQEP LF TIR N+ G ++ +I
Sbjct: 1037 YDPDSGHITLDGVELKKLRLKWLRQQMGLVGQEPVLFNDTIRANIAYGKGGEEATEAEII 1096
Query: 399 QALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSAL 220
A ELANA+RF++++ G DT VGE+G QLSGGQKQR+AIARA+V++PKILLLDEATSAL
Sbjct: 1097 AASELANAHRFISSIQKGYDTVVGERGIQLSGGQKQRVAIARAIVKEPKILLLDEATSAL 1156
Query: 219 DSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGR 40
D+ESER VQ+ALDR RT I +AHRLS+I+N+D+I + G + E G H L++ +G
Sbjct: 1157 DAESERVVQDALDRVMVNRTTIVVAHRLSTIKNADVIAVVKNGVIAEKGTHETLINIEGG 1216
Query: 39 YY 34
Y
Sbjct: 1217 VY 1218
Score = 342 bits (877), Expect = 4e-92
Identities = 199/568 (35%), Positives = 318/568 (55%), Gaps = 7/568 (1%)
Frame = -1
Query: 3675 LLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKANENVYIFLGIGIFI-- 3502
+L +GT+ ++G PI ++ +V A P K+ ++ +++ LG+ I
Sbjct: 662 ILILGTLVGAVNGTIFPIFGILFAKVIEAFFKAPHELKR-DSRFWSMIFVLLGVAAVIVY 720
Query: 3501 SITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFDK--NHSGTITTKLNDSMERIR 3328
TN++ F R++ ++R V+ GWFD+ N SG + +L+ IR
Sbjct: 721 PTTNYL----FAIAGGRLIRRIRSMCFEKVVHMEVGWFDEPGNSSGAMGARLSADAALIR 776
Query: 3327 EGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKE 3148
+GD L + ++ A L+ +++A+ W +A ++L + P I + + M +
Sbjct: 777 TLVGDSLCLSVKNVASLVTGLIIAFTASWEVAIIILVIIPFIGINGYIQIKFMKGFSADA 836
Query: 3147 LIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXX 2968
+A +A +++ +RTV +F +E+++ Y+ E K + +
Sbjct: 837 KAKYEEASQVANDAVGSIRTVASFCAEEKVMEMYKKRCEDTIKSGIKQGLISGVGFGISF 896
Query: 2967 XXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSA 2788
GA L+K G T DVF V +++ L A + S + +A
Sbjct: 897 FVLYSVYASCFYVGARLVKAGR-TNFNDVFQVFLALTLTAVGISQASSFAPDSSKGKGAA 955
Query: 2787 ASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTS 2608
SI++ IDR+ KID ++G L+NV G ++ ++ F Y +R D ++ L L + G +
Sbjct: 956 VSIFRIIDRISKIDSRDESGMVLENVKGDIELCHISFTYQTRPDVQVFRDLCLSIRAGQT 1015
Query: 2607 VALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFND 2428
VALVG SG GKST + LL R Y+P++G++T+DG ++++L ++WLR +G+V QEP+LFND
Sbjct: 1016 VALVGESGSGKSTVISLLQRFYDPDSGHITLDGVELKKLRLKWLRQQMGLVGQEPVLFND 1075
Query: 2427 TIHNNLLIGNPG--STRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVA 2254
TI N+ G G +T +I ++ANAH FI + KGYDT++G+ G+QLSGGQKQRVA
Sbjct: 1076 TIRANIAYGKGGEEATEAEIIAASELANAHRFISSIQKGYDTVVGERGIQLSGGQKQRVA 1135
Query: 2253 IARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVF 2074
IAR ++++PK+LLLDEATSALDA+SE +VQ AL+ RTTI++AHRLSTI+ AD I
Sbjct: 1136 IARAIVKEPKILLLDEATSALDAESERVVQDALDRVMVNRTTIVVAHRLSTIKNADVIAV 1195
Query: 2073 FEKGVIVEAGNHEELVRL-GGRYFDLVK 1993
+ GVI E G HE L+ + GG Y LV+
Sbjct: 1196 VKNGVIAEKGTHETLINIEGGVYASLVQ 1223
Score = 286 bits (733), Expect = 2e-75
Identities = 183/583 (31%), Positives = 303/583 (51%), Gaps = 8/583 (1%)
Frame = -1
Query: 1734 YLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAV 1555
Y F + + L M +G++ A+ G+ P + L+FG + + ++ R++
Sbjct: 16 YKLFFFSDSTDVLLMIVGSIGAIANGVCSPLMTLLFGELIDAMGPNQNNEEIVERVSKVC 75
Query: 1554 IAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLIT 1375
++ +G+G + + + E + R R + +L QD +FD G+++
Sbjct: 76 LSLVYLGLGALGAAFLQVACWMITGERQAARIRSLYLKTILRQDIGFFDVEM-TTGEVVG 134
Query: 1374 RLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLA 1195
R++ D I + ++ + + W LA +A
Sbjct: 135 RMSGDTVLILDAMGEKVGKFIQLISTFVGGFVIAFLRGWLLTLVMLTSIPLLAMSGAAIA 194
Query: 1194 YKIS-LMNVEQIQNDDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGM 1018
++ + EQ A + + + +++T+ T + Y+ +S +K+G
Sbjct: 195 IIVTRASSQEQAAYAKASNVVEQTLGSIRTVASFTGEKQAMSSYKELINLAYKSNVKQGF 254
Query: 1017 IEAINYSLTQSFMYFMMCFTYAVGI----RIIYQGDKSSDDTFKGIIAMMLGAVAVMNSA 850
+ + + M+ + TYA+G +I + + ++ ++ ++A+ ++
Sbjct: 255 VTGLGLGV----MFLVFFSTYALGTWFGGEMILRKGYTGGAVINVMVTVVSSSIALGQAS 310
Query: 849 QYFPEFVKAKTAAGMLFNIIYRKPR--TGDLMEGDRPEIRGNILFENVKFSYPQRPLQPI 676
F K AA +F I R+P T DL +IRG I +V FSYP RP + +
Sbjct: 311 PCLTAFTAGKAAAYKMFETIEREPLIDTFDLNGKVLEDIRGEIELRDVCFSYPARPKEEV 370
Query: 675 MKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQ 496
G G T ALVG SGSGKST I ++ERFYD G + IDG D+++ L +R +
Sbjct: 371 FGGFSLLIPSGTTTALVGESGSGKSTVISLIERFYDPNSGQVLIDGVDLKEFQLKWIRGK 430
Query: 495 MALVGQEPRLFAGTIRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGG 316
+ LV QEP LF+ +I EN+ G + +E+I A +LANA +F+ LP G++T VGE G
Sbjct: 431 IGLVSQEPVLFSSSIMENIGYGKEGATVEEIQAASKLANAAKFIDKLPLGLETLVGEHGT 490
Query: 315 QLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRL 136
QLSGGQKQRIAIARA+++DP+ILLLDEATSALD+ESER VQEALDR RT + +AHRL
Sbjct: 491 QLSGGQKQRIAIARAILKDPRILLLDEATSALDAESERVVQEALDRIMVNRTTVIVAHRL 550
Query: 135 SSIQNSDLIVYIDKGKVQEAGNHTQLM-HQKGRYYKLIKKQDL 10
S+++N+D+I I +GK+ E G+H++L+ +G Y +L++ Q++
Sbjct: 551 STVRNADIIAVIHRGKIVEEGSHSELLKDHEGAYSQLLRLQEI 593
>gi|17136662|ref|NP_476831.1| CG10181-PA [Drosophila melanogaster]
gi|17380460|sp|Q00748|MDR5_DROME Multidrug resistance protein homolog
65 (P-glycoprotein 65)
gi|7295351|gb|AAF50669.1| CG10181-PA [Drosophila melanogaster]
gi|7767568|gb|AAF69146.1| P-glycoprotein [Drosophila melanogaster]
gi|7767570|gb|AAF69147.1| P-glycoprotein [Drosophila melanogaster]
Length = 1302
Score = 647 bits (1670), Expect = 0.0
Identities = 435/1286 (33%), Positives = 648/1286 (49%), Gaps = 48/1286 (3%)
Frame = -1
Query: 3729 QPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQF-- 3556
+P++ LFR+ + LF G I I ++ P + ++ T+ L+ + QF
Sbjct: 29 EPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIYSEFTSMLV---DRAMQFGT 85
Query: 3555 --------------------RNKANENVYI-FLGIGIFISITNFIQYMC-------FQHC 3460
R + NE +Y + GI ++I + + ++ F
Sbjct: 86 SSNVHALPLFGGGKTLTNASREENNEALYDDSISYGILLTIASVVMFISGIFSVDVFNMV 145
Query: 3459 CTRVMAQMRHRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAM 3280
R + +MR + SV+RQ+ GW D T + D +E+IR+GI +K+G +
Sbjct: 146 ALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDGISEKVGHFVYLVVG 205
Query: 3279 LIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLM 3100
I + +++ Y W+L + P + +A+ T +E AG++AEE L
Sbjct: 206 FIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILS 265
Query: 3099 GVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAY 2920
+RTV +F G++ V RYE L RK + WK YG
Sbjct: 266 SIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVN 325
Query: 2919 LL-----KVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVP 2755
L+ TP + I +++GA + +P + AR A ++++ ID
Sbjct: 326 LIIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTS 385
Query: 2754 KIDPYSKAGKRLQ-NVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCG 2578
KIDP S GK L + G V+F++V FRYPSR + + GLN+ + G +VALVG SGCG
Sbjct: 386 KIDPLSTDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCG 445
Query: 2577 KSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGN 2398
KST V LL R Y+P G+V +D D+R+ NI+WLR+ + +V QEP+LF TI N+ G
Sbjct: 446 KSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGK 505
Query: 2397 PGSTRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVL 2218
PG+T++ + A AH+FI +P+ Y ++IG+ G QLSGGQKQR+AIAR LI++PK+L
Sbjct: 506 PGATQKEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKIL 565
Query: 2217 LLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNH 2038
LLDEATSALD QSE VQ AL+ ASKGRTTI+++HRLS IR ADKIVF G ++E G+H
Sbjct: 566 LLDEATSALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSH 625
Query: 2037 EELVRLGGRYFDLVKAQQFKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRR 1858
++L+ L G Y+++V+A ++DT F +
Sbjct: 626 DDLMALEGAYYNMVRAGDINMPDEVEKED-----SIEDTKQKSLALFEKSFETSPLNFEK 680
Query: 1857 GNSLNDSFSGSKRSXXXXXXXXXXXXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGT 1678
G + F E + I + AK + Y+ LGT
Sbjct: 681 GQKNSVQF----EEPIIKALIKDTNAQSAEAPPEKPNFFRTFSRILQLAKQEWCYLILGT 736
Query: 1677 VFALIRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLA--S 1504
+ A+ G PA A+IFG + + AV+++A +G+ +
Sbjct: 737 ISAVAVGFLYPAFAVIFGEFYAALAEKDPEDALRR---TAVLSWACLGLAFLTGLVCFLQ 793
Query: 1503 SVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARM 1324
+ LF L+ R R +F ++ Q+ +FD+ ++ G L RL+ +A +I+ + +
Sbjct: 794 TYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPL 853
Query: 1323 LQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQ-NDDA 1147
+ Y W+ + +I A +S V + Q ++A
Sbjct: 854 SGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNAVVREKQVIEEA 913
Query: 1146 GRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMM 967
RIA E I N++T+ L R Y ++ + +K + S Q+ +F
Sbjct: 914 CRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTMQASAFFAY 973
Query: 966 CFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIY 787
G ++ +G D K ++ G++ + S + P F A A LF I+
Sbjct: 974 AVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQILD 1033
Query: 786 RKPRTGDLMEGDRPEIRGNI-LFENVK-----FSYPQRPLQPIMKGLQWTALRGQTVALV 625
RKP+ M + + + LFE V+ F YP RP I+ GL L+GQTVALV
Sbjct: 1034 RKPKIQSPMGTIKNTLAKQLNLFEGVRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALV 1093
Query: 624 GPSGSGKSTNIGMLERFYDVTGGALRIDGQDIR-KLSLFHLRTQMALVGQEPRLFAGTIR 448
G SG GKST + +L+R+YD G + ID DI+ L+L +RT++ +V QEP LF +I
Sbjct: 1094 GHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIA 1153
Query: 447 ENVCLG--LKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIAR 274
EN+ G + V + +I A + ANA+ F+ +LP G DT +G +G QLSGGQKQRIAIAR
Sbjct: 1154 ENIAYGDNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIAR 1213
Query: 273 ALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDK 94
ALVR+PKILLLDEATSALD +SE+ VQ+ALD A GRTCI IAHRLS++QN+D+I I
Sbjct: 1214 ALVRNPKILLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQN 1273
Query: 93 GKVQEAGNHTQLMHQKGRYYKLIKKQ 16
G+V E GNH QL+ Q G Y KL K Q
Sbjct: 1274 GQVVEQGNHMQLISQGGIYAKLHKTQ 1299
Score = 338 bits (868), Expect = 5e-91
Identities = 213/605 (35%), Positives = 314/605 (51%), Gaps = 17/605 (2%)
Frame = -1
Query: 3747 NQQLEAQPVSIPGLFRYGKKF------DYLLLFIGTICAIISGVSQPILALVSGRVTNAL 3586
N Q P P FR + ++ L +GTI A+ G P A++ G AL
Sbjct: 701 NAQSAEAPPEKPNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFYAAL 760
Query: 3585 LVYPPTSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLR 3406
P R + LG+ + F+Q F + + +MR +++
Sbjct: 761 AEKDPEDALRRTAVLS--WACLGLAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVN 818
Query: 3405 QNAGWFD--KNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLA 3232
Q GWFD N G ++ +L+ I+ IG L +++ + I+++ VA Y W+LA
Sbjct: 819 QEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLA 878
Query: 3231 SMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVG 3052
+ L P + L A+ M++ ++E + +A IA ES+ +RTV + +++
Sbjct: 879 LLCLANCPIIVGSVILEAKMMSNAVVREKQVIEEACRIATESITNIRTVAGLRREADVIR 938
Query: 3051 RYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIV 2872
Y E+++ K + YG L+ G + D+ V
Sbjct: 939 EYTEEIQRVEVLIRQKLRWRGVLNSTMQASAFFAYAVALCYGGVLVSEGQLPFQ-DIIKV 997
Query: 2871 VMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDP-----YSKAGKRLQNVV 2707
++L G+ L A ++ ++Q +DR PKI + K+L N+
Sbjct: 998 SETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQILDRKPKIQSPMGTIKNTLAKQL-NLF 1056
Query: 2706 GRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAG 2527
V++ + FRYP+R DAKILNGL+L V G +VALVGHSGCGKST V LL R Y+P+ G
Sbjct: 1057 EGVRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEG 1116
Query: 2526 NVTIDGTDVR-ELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEV---CK 2359
+ ID D++ +L ++ +R +GIV QEP LF +I N+ G+ +M+E+ K
Sbjct: 1117 TIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGD-NRRSVSMVEIIAAAK 1175
Query: 2358 MANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQS 2179
ANAH FI +P GYDT +G G QLSGGQKQR+AIAR L+R+PK+LLLDEATSALD QS
Sbjct: 1176 SANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQS 1235
Query: 2178 ESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDL 1999
E +VQ AL+ A GRT I+IAHRLST++ AD I + G +VE GNH +L+ GG Y L
Sbjct: 1236 EQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLISQGGIYAKL 1295
Query: 1998 VKAQQ 1984
K Q+
Sbjct: 1296 HKTQK 1300
Score = 269 bits (688), Expect = 4e-70
Identities = 185/614 (30%), Positives = 301/614 (48%), Gaps = 39/614 (6%)
Frame = -1
Query: 1734 YLDIFK-NAKGNYLYMFLGTVFALIRGLELPALALIFGW--------------------- 1621
+L +F+ + G ++F G + I+ L LPA+ +I+
Sbjct: 33 FLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIYSEFTSMLVDRAMQFGTSSNVHAL 92
Query: 1620 -VFEGFTFVPYGGRMMHRMAMAV------IAFASVGVGVWFSQLASSVLFAVVSENLSMR 1462
+F G + R + A+ I V ++ S + S +F +V+ R
Sbjct: 93 PLFGGGKTLTNASREENNEALYDDSISYGILLTIASVVMFISGIFSVDVFNMVALRQVTR 152
Query: 1461 FRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXX 1282
R++ F +++ QD + D + + D I+ + ++
Sbjct: 153 MRIKLFSSVIRQDIGWHDLASKQ--NFTQSMVDDVEKIRDGISEKVGHFVYLVVGFIITV 210
Query: 1281 XXXXIYCWQXXXXXXXXXXXLAFVMIGLA-YKISLMNVEQIQNDDAGRIAIEIIENVKTI 1105
Y W+ + + +A ++ L EQ AG +A EI+ +++T+
Sbjct: 211 AISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILSSIRTV 270
Query: 1104 QLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQG 925
+ Y+ +++ KG ++ ++ +S +Y + G+ +I
Sbjct: 271 VSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNLIIDD 330
Query: 924 DKSSDDTFKGIIAMM------LGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDL 763
+ + I M+ +GA + +A + F A+ A LF +I + L
Sbjct: 331 RNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPL 390
Query: 762 MEGDRP---EIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNI 592
+ +RG++ F++V F YP RP + +GL GQTVALVG SG GKST +
Sbjct: 391 STDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCV 450
Query: 591 GMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGLKDVPL 412
+L+RFYD G++ +D DIRK ++ LR+ +A+VGQEP LF GTI +N+ G
Sbjct: 451 QLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQ 510
Query: 411 EKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEA 232
++I A A A+ F+ NLP + +GE+G QLSGGQKQRIAIARAL+++PKILLLDEA
Sbjct: 511 KEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEA 570
Query: 231 TSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMH 52
TSALD +SE+ VQ+ALD A +GRT I ++HRLS+I+ +D IV+I GKV E G+H LM
Sbjct: 571 TSALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMA 630
Query: 51 QKGRYYKLIKKQDL 10
+G YY +++ D+
Sbjct: 631 LEGAYYNMVRAGDI 644
>gi|21464386|gb|AAM51996.1| RE14657p [Drosophila melanogaster]
Length = 1302
Score = 647 bits (1669), Expect = 0.0
Identities = 435/1286 (33%), Positives = 648/1286 (49%), Gaps = 48/1286 (3%)
Frame = -1
Query: 3729 QPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQF-- 3556
+P++ LFR+ + LF G I I ++ P + ++ T+ L+ + QF
Sbjct: 29 EPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIYSEFTSMLV---DRAMQFGT 85
Query: 3555 --------------------RNKANENVYI-FLGIGIFISITNFIQYMC-------FQHC 3460
R + NE +Y + GI ++I + + ++ F
Sbjct: 86 SSNVHALPLFGGGKTLTNASREENNEALYDDSISYGILLTIASVVMFISGIFSVDVFNMV 145
Query: 3459 CTRVMAQMRHRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAM 3280
R + +MR + SV+RQ+ GW D T + D +E+IR+GI +K+G +
Sbjct: 146 ALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDGISEKVGHFVYLVVG 205
Query: 3279 LIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLM 3100
I + +++ Y W+L + P + +A+ T +E AG++AEE L
Sbjct: 206 FIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILS 265
Query: 3099 GVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAY 2920
+RTV +F G++ V RYE L RK + WK YG
Sbjct: 266 SIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVN 325
Query: 2919 LL-----KVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVP 2755
L+ TP + I +++GA + +P + AR A ++++ ID
Sbjct: 326 LIIDDRDVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTS 385
Query: 2754 KIDPYSKAGKRLQ-NVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCG 2578
KIDP S GK L + G V+F++V FRYPSR + + GLN+ + G +VALVG SGCG
Sbjct: 386 KIDPLSTDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCG 445
Query: 2577 KSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGN 2398
KST V LL R Y+P G+V +D D+R+ NI+WLR+ + +V QEP+LF TI N+ G
Sbjct: 446 KSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGK 505
Query: 2397 PGSTRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVL 2218
PG+T++ + A AH+FI +P+ Y ++IG+ G QLSGGQKQR+AIAR LI++PK+L
Sbjct: 506 PGATQKEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKIL 565
Query: 2217 LLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNH 2038
LLDEATSALD QSE VQ AL+ ASKGRTTI+++HRLS IR ADKIVF G ++E G+H
Sbjct: 566 LLDEATSALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSH 625
Query: 2037 EELVRLGGRYFDLVKAQQFKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRR 1858
++L+ L G Y+++V+A ++DT F +
Sbjct: 626 DDLMALEGAYYNMVRAGDINMPDEVEKED-----SIEDTKQKSLALFEKSFETSPLNFEK 680
Query: 1857 GNSLNDSFSGSKRSXXXXXXXXXXXXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGT 1678
G + F E + I + AK + Y+ LGT
Sbjct: 681 GQKNSVQF----EEPIIKALIKDTNAQSAEAPPEKPNFFRTFSRILQLAKQEWCYLILGT 736
Query: 1677 VFALIRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLA--S 1504
+ A+ G PA A+IFG + + AV+++A +G+ +
Sbjct: 737 ISAVAVGFLYPAFAVIFGEFYAALAEKDPEDALRR---TAVLSWACLGLAFLTGLVCFLQ 793
Query: 1503 SVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARM 1324
+ LF L+ R R +F ++ Q+ +FD+ ++ G L RL+ +A +I+ + +
Sbjct: 794 TYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPL 853
Query: 1323 LQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQ-NDDA 1147
+ Y W+ + +I A +S V + Q ++A
Sbjct: 854 SGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNAVVREKQVIEEA 913
Query: 1146 GRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMM 967
RIA E I N++T+ L R Y ++ + +K + S Q+ +F
Sbjct: 914 CRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTMQASAFFAY 973
Query: 966 CFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIY 787
G ++ +G D K ++ G++ + S + P F A A LF I+
Sbjct: 974 AVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQILD 1033
Query: 786 RKPRTGDLMEGDRPEIRGNI-LFENVK-----FSYPQRPLQPIMKGLQWTALRGQTVALV 625
RKP+ M + + + LFE V+ F YP RP I+ GL L+GQTVALV
Sbjct: 1034 RKPKIQSPMGTIKNTLAKQLNLFEGVRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALV 1093
Query: 624 GPSGSGKSTNIGMLERFYDVTGGALRIDGQDIR-KLSLFHLRTQMALVGQEPRLFAGTIR 448
G SG GKST + +L+R+YD G + ID DI+ L+L +RT++ +V QEP LF +I
Sbjct: 1094 GHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIA 1153
Query: 447 ENVCLG--LKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIAR 274
EN+ G + V + +I A + ANA+ F+ +LP G DT +G +G QLSGGQKQRIAIAR
Sbjct: 1154 ENIVYGDNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIAR 1213
Query: 273 ALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDK 94
ALVR+PKILLLDEATSALD +SE+ VQ+ALD A GRTCI IAHRLS++QN+D+I I
Sbjct: 1214 ALVRNPKILLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQN 1273
Query: 93 GKVQEAGNHTQLMHQKGRYYKLIKKQ 16
G+V E GNH QL+ Q G Y KL K Q
Sbjct: 1274 GQVVEQGNHMQLISQGGIYAKLHKTQ 1299
Score = 339 bits (870), Expect = 3e-91
Identities = 213/605 (35%), Positives = 315/605 (51%), Gaps = 17/605 (2%)
Frame = -1
Query: 3747 NQQLEAQPVSIPGLFRYGKKF------DYLLLFIGTICAIISGVSQPILALVSGRVTNAL 3586
N Q P P FR + ++ L +GTI A+ G P A++ G AL
Sbjct: 701 NAQSAEAPPEKPNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFYAAL 760
Query: 3585 LVYPPTSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLR 3406
P R + LG+ + F+Q F + + +MR +++
Sbjct: 761 AEKDPEDALRRTAVLS--WACLGLAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVN 818
Query: 3405 QNAGWFD--KNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLA 3232
Q GWFD N G ++ +L+ I+ IG L +++ + I+++ VA Y W+LA
Sbjct: 819 QEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLA 878
Query: 3231 SMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVG 3052
+ L P + L A+ M++ ++E + +A IA ES+ +RTV + +++
Sbjct: 879 LLCLANCPIIVGSVILEAKMMSNAVVREKQVIEEACRIATESITNIRTVAGLRREADVIR 938
Query: 3051 RYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIV 2872
Y E+++ K + YG L+ G + D+ V
Sbjct: 939 EYTEEIQRVEVLIRQKLRWRGVLNSTMQASAFFAYAVALCYGGVLVSEGQLPFQ-DIIKV 997
Query: 2871 VMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDP-----YSKAGKRLQNVV 2707
++L G+ L A ++ ++Q +DR PKI + K+L N+
Sbjct: 998 SETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQILDRKPKIQSPMGTIKNTLAKQL-NLF 1056
Query: 2706 GRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAG 2527
V++ + FRYP+R DAKILNGL+L V G +VALVGHSGCGKST V LL R Y+P+ G
Sbjct: 1057 EGVRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEG 1116
Query: 2526 NVTIDGTDVR-ELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEV---CK 2359
+ ID D++ +L ++ +R +GIV QEP LF +I N++ G+ +M+E+ K
Sbjct: 1117 TIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIVYGD-NRRSVSMVEIIAAAK 1175
Query: 2358 MANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQS 2179
ANAH FI +P GYDT +G G QLSGGQKQR+AIAR L+R+PK+LLLDEATSALD QS
Sbjct: 1176 SANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQS 1235
Query: 2178 ESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDL 1999
E +VQ AL+ A GRT I+IAHRLST++ AD I + G +VE GNH +L+ GG Y L
Sbjct: 1236 EQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLISQGGIYAKL 1295
Query: 1998 VKAQQ 1984
K Q+
Sbjct: 1296 HKTQK 1300
Score = 269 bits (687), Expect = 5e-70
Identities = 185/614 (30%), Positives = 301/614 (48%), Gaps = 39/614 (6%)
Frame = -1
Query: 1734 YLDIFK-NAKGNYLYMFLGTVFALIRGLELPALALIFGW--------------------- 1621
+L +F+ + G ++F G + I+ L LPA+ +I+
Sbjct: 33 FLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIYSEFTSMLVDRAMQFGTSSNVHAL 92
Query: 1620 -VFEGFTFVPYGGRMMHRMAMAV------IAFASVGVGVWFSQLASSVLFAVVSENLSMR 1462
+F G + R + A+ I V ++ S + S +F +V+ R
Sbjct: 93 PLFGGGKTLTNASREENNEALYDDSISYGILLTIASVVMFISGIFSVDVFNMVALRQVTR 152
Query: 1461 FRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXX 1282
R++ F +++ QD + D + + D I+ + ++
Sbjct: 153 MRIKLFSSVIRQDIGWHDLASKQ--NFTQSMVDDVEKIRDGISEKVGHFVYLVVGFIITV 210
Query: 1281 XXXXIYCWQXXXXXXXXXXXLAFVMIGLA-YKISLMNVEQIQNDDAGRIAIEIIENVKTI 1105
Y W+ + + +A ++ L EQ AG +A EI+ +++T+
Sbjct: 211 AISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILSSIRTV 270
Query: 1104 QLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQG 925
+ Y+ +++ KG ++ ++ +S +Y + G+ +I
Sbjct: 271 VSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNLIIDD 330
Query: 924 DKSSDDTFKGIIAMM------LGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDL 763
+ + I M+ +GA + +A + F A+ A LF +I + L
Sbjct: 331 RDVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPL 390
Query: 762 MEGDRP---EIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNI 592
+ +RG++ F++V F YP RP + +GL GQTVALVG SG GKST +
Sbjct: 391 STDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCV 450
Query: 591 GMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGLKDVPL 412
+L+RFYD G++ +D DIRK ++ LR+ +A+VGQEP LF GTI +N+ G
Sbjct: 451 QLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQ 510
Query: 411 EKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEA 232
++I A A A+ F+ NLP + +GE+G QLSGGQKQRIAIARAL+++PKILLLDEA
Sbjct: 511 KEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEA 570
Query: 231 TSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMH 52
TSALD +SE+ VQ+ALD A +GRT I ++HRLS+I+ +D IV+I GKV E G+H LM
Sbjct: 571 TSALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMA 630
Query: 51 QKGRYYKLIKKQDL 10
+G YY +++ D+
Sbjct: 631 LEGAYYNMVRAGDI 644
>gi|4204793|gb|AAD10836.1| P-glycoprotein [Solanum tuberosum]
Length = 1313
Score = 646 bits (1666), Expect = 0.0
Identities = 410/1279 (32%), Positives = 659/1279 (51%), Gaps = 31/1279 (2%)
Frame = -1
Query: 3759 GDIANQQLEAQPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLV 3580
GD+ V LFR+ D +L+ IG++ A + G S P+ + N+
Sbjct: 41 GDVEKPSSPPPAVGFGELFRFADGLDCVLMIIGSLGAFVHGCSLPLFLRFFADLVNSFGS 100
Query: 3579 YPPTSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQN 3400
Y + + + + FL +G I +++ + C+ R +MR +++ + L Q+
Sbjct: 101 YANDVDKMTQEVLKYAFYFLVVGAAIWASSWAEISCWMWTGERQTTKMRIKYLEAALNQD 160
Query: 3399 AGWFDKN-HSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMM 3223
+FD + + + +N +++ I +KLG + A ++ VV + W+LA +
Sbjct: 161 IQYFDTEVRTSDVVSAINTDAVVVQDAISEKLGNFIHYMATFLSGFVVGFTAVWQLALVT 220
Query: 3222 LGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYE 3043
L V P + ++ + + + KAG+I E++++ +RTV F G+ + + Y
Sbjct: 221 LAVVPLIAVIGAIYTVTSAKLSSQSQEALSKAGNIVEQTVVQIRTVLVFVGEAKALQAYT 280
Query: 3042 AELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMS 2863
A L +K + YG YL++ T G + +
Sbjct: 281 AALRVSQKIGYKSGFSKGLGLGATYFTVFCCYALLLWYGGYLVRHHF-TNGGLAIATMFA 339
Query: 2862 MLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENV 2683
+++G LG +P M ARV+AA I++ ID P +D +K G L V G+++ +NV
Sbjct: 340 VMIGGLALGQSAPSMTAFAKARVAAAKIFRIIDHKPSVDRNAKTGLELDTVSGQLELKNV 399
Query: 2682 HFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTD 2503
F YPSR + KILN NLVV G ++ALVG SG GKST V L+ R Y+P +G + +DG D
Sbjct: 400 EFSYPSRPEIKILNNFNLVVPAGKTIALVGSSGSGKSTVVSLIERFYDPTSGQLMLDGND 459
Query: 2502 VRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMP 2323
++ L ++WLR +G+V QEP LF +I N+L+G P +T+ + E ++ANAH F+ K+P
Sbjct: 460 IKTLKLKWLRQQIGLVSQEPALFATSIKENILLGRPDATQIEIEEAARVANAHSFVIKLP 519
Query: 2322 KGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNAS 2143
G+DT +G+ G+QLSGGQKQR+AIAR ++++P +LLLDEATSALD++SE +VQ AL+
Sbjct: 520 DGFDTQVGERGLQLSGGQKQRIAIARAMLKNPAILLLDEATSALDSESEKLVQEALDRFM 579
Query: 2142 KGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLG--GRYFDLVKAQQFKADP 1969
GRTT++IAHRLSTIR+AD + ++G + E G+H+EL+ G G Y L+K Q+ +
Sbjct: 580 IGRTTLVIAHRLSTIRKADLVAVLQQGSVSEIGSHDELMSKGENGMYAKLIKMQEAAHET 639
Query: 1968 XXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXXXXX 1789
L + S R +S S S+R
Sbjct: 640 A-----------LSNARKSSARPSSARNSVSSPIITRNSSYGRS-PYSRRLSDFSTSDFS 687
Query: 1788 XXXXXXXXXXEDGQI-----TAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFG 1624
+ ++ + + + K + Y +G++ ++I G +L+ F
Sbjct: 688 LSLDAAYSNYRNEKLAFKDQASSFGRLAKMNSPEWTYALIGSIGSVICG----SLSAFFA 743
Query: 1623 WVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVL----FAVVSENLSMRFR 1456
+V V Y + M+ + + + +GV + L + L + VV ENL+ R R
Sbjct: 744 YVLSAVLSVYYNPDHAY-MSEQIAKYCYLLIGVSSAALIFNTLQHYYWDVVGENLTKRVR 802
Query: 1455 VQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXX 1276
+ +L + ++FD + ++ RL+ DA N+++ + R+ +
Sbjct: 803 EKMLAAVLKMEMAWFDQEENDSSRIAARLSLDANNVRSAIGDRISVIMQNSALMLVACTA 862
Query: 1275 XXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQND------DAGRIAIEIIENV 1114
+ W+ F ++ A + M ++ D A ++A E + NV
Sbjct: 863 GFVLQWR-----LALVLIGVFPVVVAATVLQKMFMKGFSGDLEAAHAKATQLAGEAVANV 917
Query: 1113 KTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGI--- 943
+T+ + + +S + R KG I Y + Q F++ +YA+G+
Sbjct: 918 RTVAAFNSETKIVNLFDSSLQTPLRRCFWKGQIAGSGYGIAQ----FLLYSSYALGLWYA 973
Query: 942 -RIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGD 766
++ G T + + +M+ A + P+F+K A +F ++ RK
Sbjct: 974 SWLVKHGISDFSKTIRVFMVLMVSANGAAETLTLAPDFIKGGRAMRSVFELLDRKTE--- 1030
Query: 765 LMEGDRPE-------IRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSG 607
+E D P+ +RG + F++V FSYP RP I + L A G+T+ALVGPSG G
Sbjct: 1031 -VEPDDPDATAVPDRLRGEVEFKHVDFSYPTRPDVSIFRDLNLRARAGKTLALVGPSGCG 1089
Query: 606 KSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGL 427
KS+ I ++ERFY+ + G + IDG+DIRK +L LR +A+V QEP LFA TI EN+ G
Sbjct: 1090 KSSVISLIERFYEPSSGRVIIDGKDIRKYNLKSLRRHIAVVPQEPCLFATTIYENIAYGH 1149
Query: 426 KDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKIL 247
+ +I +A LANA++F++ LP G T VGE+G QLSGGQKQRIAIARA +R +++
Sbjct: 1150 ESATEAEITEAATLANAHKFISALPDGYKTFVGERGVQLSGGQKQRIAIARAFLRKAELM 1209
Query: 246 LLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNH 67
LLDEATSALD+ESER VQEALDRA G+T I +AHRLS+I+N+ +I ID GKV E G+H
Sbjct: 1210 LLDEATSALDAESERCVQEALDRACAGKTTIVVAHRLSTIRNAHVIAVIDDGKVAEQGSH 1269
Query: 66 TQLM--HQKGRYYKLIKKQ 16
+ L+ + G Y ++I+ Q
Sbjct: 1270 SHLLKNYSDGIYARMIQLQ 1288
Score = 333 bits (853), Expect = 3e-89
Identities = 192/575 (33%), Positives = 309/575 (53%), Gaps = 7/575 (1%)
Frame = -1
Query: 3684 DYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKANENVYIFLGIGIF 3505
++ IG+I ++I G A V V + + Y P + + Y+ +G+
Sbjct: 721 EWTYALIGSIGSVICGSLSAFFAYVLSAVLS--VYYNPDHAYMSEQIAKYCYLLIGVSSA 778
Query: 3504 ISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFDK--NHSGTITTKLNDSMERI 3331
I N +Q+ + + ++R + + +VL+ WFD+ N S I +L+ +
Sbjct: 779 ALIFNTLQHYYWDVVGENLTKRVREKMLAAVLKMEMAWFDQEENDSSRIAARLSLDANNV 838
Query: 3330 REGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIK 3151
R IGD++ V+++ A+++ A ++ +WRLA +++GV P L M +
Sbjct: 839 RSAIGDRISVIMQNSALMLVACTAGFVLQWRLALVLIGVFPVVVAATVLQKMFMKGFSGD 898
Query: 3150 ELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXX 2971
KA +A E++ VRTV AFN + ++V +++ L+ + WK
Sbjct: 899 LEAAHAKATQLAGEAVANVRTVAAFNSETKIVNLFDSSLQTPLRRCFWKGQIAGSGYGIA 958
Query: 2970 XXXXXXXXGCGMLYGAYLLKVGI--ITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNAR 2797
G+ Y ++L+K GI + VF+V+M GA ++P +
Sbjct: 959 QFLLYSSYALGLWYASWLVKHGISDFSKTIRVFMVLMVSANGAAETLTLAPDF---IKGG 1015
Query: 2796 VSAASIYQTIDRVPKIDPYSKAGKRLQNVV-GRVKFENVHFRYPSRKDAKILNGLNLVVE 2620
+ S+++ +DR +++P + + + G V+F++V F YP+R D I LNL
Sbjct: 1016 RAMRSVFELLDRKTEVEPDDPDATAVPDRLRGEVEFKHVDFSYPTRPDVSIFRDLNLRAR 1075
Query: 2619 PGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPI 2440
G ++ALVG SGCGKS+ + L+ R YEP +G V IDG D+R+ N++ LR + +V QEP
Sbjct: 1076 AGKTLALVGPSGCGKSSVISLIERFYEPSSGRVIIDGKDIRKYNLKSLRRHIAVVPQEPC 1135
Query: 2439 LFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQR 2260
LF TI+ N+ G+ +T + E +ANAH FI +P GY T +G+ GVQLSGGQKQR
Sbjct: 1136 LFATTIYENIAYGHESATEAEITEAATLANAHKFISALPDGYKTFVGERGVQLSGGQKQR 1195
Query: 2259 VAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKI 2080
+AIAR +R +++LLDEATSALDA+SE VQ AL+ A G+TTI++AHRLSTIR A I
Sbjct: 1196 IAIARAFLRKAELMLLDEATSALDAESERCVQEALDRACAGKTTIVVAHRLSTIRNAHVI 1255
Query: 2079 VFFEKGVIVEAGNHEELVR--LGGRYFDLVKAQQF 1981
+ G + E G+H L++ G Y +++ Q+F
Sbjct: 1256 AVIDDGKVAEQGSHSHLLKNYSDGIYARMIQLQRF 1290
Score = 311 bits (796), Expect = 1e-82
Identities = 205/594 (34%), Positives = 305/594 (50%), Gaps = 17/594 (2%)
Frame = -1
Query: 1737 GYLDIFKNAKG-NYLYMFLGTVFALIRGLELPALALIFGWVFEGF-TFVPYGGRMMHRMA 1564
G+ ++F+ A G + + M +G++ A + G LP F + F ++ +M +
Sbjct: 54 GFGELFRFADGLDCVLMIIGSLGAFVHGCSLPLFLRFFADLVNSFGSYANDVDKMTQEVL 113
Query: 1563 MAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGK 1384
F VG +W S A + E + + R++ L QD YFD
Sbjct: 114 KYAFYFLVVGAAIWASSWAEISCWMWTGERQTTKMRIKYLEAALNQDIQYFDTEVRT-SD 172
Query: 1383 LITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMI 1204
+++ + +DA ++ + ++ WQ +A +I
Sbjct: 173 VVSAINTDAVVVQDAISEKLGNFIHYMATFLSGFVVGFTAVWQLALVTLAVVPLIA--VI 230
Query: 1203 GLAYKIS---LMNVEQIQNDDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSE 1033
G Y ++ L + Q AG I + + ++T+ + Y + + ++
Sbjct: 231 GAIYTVTSAKLSSQSQEALSKAGNIVEQTVVQIRTVLVFVGEAKALQAYTAALRVSQKIG 290
Query: 1032 LKKGMIEAINYSLTQSFMYFMMCFTYAV----GIRIIYQGDKSSDDTFKGIIAMMLGAVA 865
K G + + T YF + YA+ G ++ + + A+M+G +A
Sbjct: 291 YKSGFSKGLGLGAT----YFTVFCCYALLLWYGGYLVRHHFTNGGLAIATMFAVMIGGLA 346
Query: 864 VMNSAQYFPEFVKAKTAAGMLFNIIYRKP------RTGDLMEGDRPEIRGNILFENVKFS 703
+ SA F KA+ AA +F II KP +TG +E D + G + +NV+FS
Sbjct: 347 LGQSAPSMTAFAKARVAAAKIFRIIDHKPSVDRNAKTG--LELDT--VSGQLELKNVEFS 402
Query: 702 YPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRK 523
YP RP I+ G+T+ALVG SGSGKST + ++ERFYD T G L +DG DI+
Sbjct: 403 YPSRPEIKILNNFNLVVPAGKTIALVGSSGSGKSTVVSLIERFYDPTSGQLMLDGNDIKT 462
Query: 522 LSLFHLRTQMALVGQEPRLFAGTIRENVCLGLKDVPLEKINQALELANANRFLANLPAGI 343
L L LR Q+ LV QEP LFA +I+EN+ LG D +I +A +ANA+ F+ LP G
Sbjct: 463 LKLKWLRQQIGLVSQEPALFATSIKENILLGRPDATQIEIEEAARVANAHSFVIKLPDGF 522
Query: 342 DTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGR 163
DT VGE+G QLSGGQKQRIAIARA++++P ILLLDEATSALDSESE+ VQEALDR GR
Sbjct: 523 DTQVGERGLQLSGGQKQRIAIARAMLKNPAILLLDEATSALDSESEKLVQEALDRFMIGR 582
Query: 162 TCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMH--QKGRYYKLIKKQDLA 7
T + IAHRLS+I+ +DL+ + +G V E G+H +LM + G Y KLIK Q+ A
Sbjct: 583 TTLVIAHRLSTIRKADLVAVLQQGSVSEIGSHDELMSKGENGMYAKLIKMQEAA 636
>gi|103252|pir||B41249 multidrug resistance protein homolog Mdr65 -
fruit fly (Drosophila melanogaster)
gi|157875|gb|AAA28680.1| P-glycoprotein
Length = 1302
Score = 645 bits (1665), Expect = 0.0
Identities = 434/1286 (33%), Positives = 648/1286 (49%), Gaps = 48/1286 (3%)
Frame = -1
Query: 3729 QPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQF-- 3556
+P++ LFR+ + LF G I I ++ P + ++ T+ L+ + QF
Sbjct: 29 EPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIYSEFTSMLV---DRAMQFGT 85
Query: 3555 --------------------RNKANENVYI-FLGIGIFISITNFIQYMC-------FQHC 3460
R + NE +Y + GI ++I + + ++ F
Sbjct: 86 SSNVHALPLFGGGKTLTNASREENNEALYDDSISYGILLTIASVVMFISGIFSVDVFNMV 145
Query: 3459 CTRVMAQMRHRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAM 3280
R + +MR + SV+RQ+ GW D T + D +E+IR+GI +K+G +
Sbjct: 146 ALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDGISEKVGHFVYLVVG 205
Query: 3279 LIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLM 3100
I + +++ Y W+L + P + +A+ T +E AG++AEE L
Sbjct: 206 FIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILS 265
Query: 3099 GVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAY 2920
+RTV +F G++ V RYE L RK + WK YG
Sbjct: 266 SIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVN 325
Query: 2919 LL-----KVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVP 2755
L+ TP + I +++GA + +P + +AR A ++++ ID
Sbjct: 326 LIIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFASARGCATNLFKVIDLTS 385
Query: 2754 KIDPYSKAGKRLQ-NVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCG 2578
KIDP S GK L + G V+F++V FRYPSR + + GLN+ + G +VALVG SGCG
Sbjct: 386 KIDPLSTDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCG 445
Query: 2577 KSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGN 2398
KST V LL R Y+P G+V +D D+R+ NI+WLR+ + +V QEP+LF TI N+ G
Sbjct: 446 KSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGK 505
Query: 2397 PGSTRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVL 2218
PG+T++ + A AH+FI +P+ Y ++IG+ G QLSGGQKQR+AIAR LI++PK+L
Sbjct: 506 PGATQKEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKIL 565
Query: 2217 LLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNH 2038
LLDEATSALD QSE VQ AL+ ASKGRTTI+++HRLS IR ADKIVF G ++E G+H
Sbjct: 566 LLDEATSALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSH 625
Query: 2037 EELVRLGGRYFDLVKAQQFKADPXXXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRR 1858
++L+ L G Y+++V+A ++DT +
Sbjct: 626 DDLMALEGAYYNMVRAGDINMPDEVEKED-----SIEDTKQKSLALFEKSFETSPLNLEK 680
Query: 1857 GNSLNDSFSGSKRSXXXXXXXXXXXXXXXXXXXEDGQITAGYLDIFKNAKGNYLYMFLGT 1678
G + F E + I + AK + Y+ LGT
Sbjct: 681 GQKNSVQF----EEPIIKALIKDTNAQSAEAPPEKPNFFRTFSRILQLAKQEWCYLILGT 736
Query: 1677 VFALIRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLA--S 1504
+ A+ G PA A+IFG + + AV+++A +G+ +
Sbjct: 737 ISAVAVGFLYPAFAVIFGEFYAALAEKDPEDALRR---TAVLSWACLGLAFLTGLVCFLQ 793
Query: 1503 SVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARM 1324
+ LF L+ R R +F ++ Q+ +FD+ ++ G L RL+ +A +I+ + +
Sbjct: 794 TYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPL 853
Query: 1323 LQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQ-NDDA 1147
+ Y W+ + +I A +S V + Q ++A
Sbjct: 854 SGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNAVVREKQVIEEA 913
Query: 1146 GRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMM 967
RIA E I N++T+ L R Y ++ + +K + S Q+ +F
Sbjct: 914 CRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTMQASAFFAY 973
Query: 966 CFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIY 787
G ++ +G D K ++ G++ + S + P F A A LF I+
Sbjct: 974 AVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQILD 1033
Query: 786 RKPRTGDLMEGDRPEIRGNI-LFENVK-----FSYPQRPLQPIMKGLQWTALRGQTVALV 625
RKP+ M + + + LFE V+ F YP RP I+ GL L+GQTVALV
Sbjct: 1034 RKPKIQSPMGTIKNTLAKQLNLFEGVRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALV 1093
Query: 624 GPSGSGKSTNIGMLERFYDVTGGALRIDGQDIR-KLSLFHLRTQMALVGQEPRLFAGTIR 448
G SG GKST + +L+R+YD G + ID DI+ L+L +RT++ +V QEP LF +I
Sbjct: 1094 GHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIA 1153
Query: 447 ENVCLG--LKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIAR 274
EN+ G + V + +I A + ANA+ F+ +LP G DT +G +G QLSGGQKQRIAIAR
Sbjct: 1154 ENIAYGDNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIAR 1213
Query: 273 ALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDK 94
ALVR+PKILLLDEATSALD +SE+ VQ+ALD A GRTCI IAHRLS++QN+D+I I
Sbjct: 1214 ALVRNPKILLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQN 1273
Query: 93 GKVQEAGNHTQLMHQKGRYYKLIKKQ 16
G+V E GNH QL+ Q G Y KL K Q
Sbjct: 1274 GQVVEQGNHMQLISQGGIYAKLHKTQ 1299
Score = 338 bits (868), Expect = 5e-91
Identities = 213/605 (35%), Positives = 314/605 (51%), Gaps = 17/605 (2%)
Frame = -1
Query: 3747 NQQLEAQPVSIPGLFRYGKKF------DYLLLFIGTICAIISGVSQPILALVSGRVTNAL 3586
N Q P P FR + ++ L +GTI A+ G P A++ G AL
Sbjct: 701 NAQSAEAPPEKPNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFYAAL 760
Query: 3585 LVYPPTSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLR 3406
P R + LG+ + F+Q F + + +MR +++
Sbjct: 761 AEKDPEDALRRTAVLS--WACLGLAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVN 818
Query: 3405 QNAGWFD--KNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLA 3232
Q GWFD N G ++ +L+ I+ IG L +++ + I+++ VA Y W+LA
Sbjct: 819 QEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLA 878
Query: 3231 SMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVG 3052
+ L P + L A+ M++ ++E + +A IA ES+ +RTV + +++
Sbjct: 879 LLCLANCPIIVGSVILEAKMMSNAVVREKQVIEEACRIATESITNIRTVAGLRREADVIR 938
Query: 3051 RYEAELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIV 2872
Y E+++ K + YG L+ G + D+ V
Sbjct: 939 EYTEEIQRVEVLIRQKLRWRGVLNSTMQASAFFAYAVALCYGGVLVSEGQLPFQ-DIIKV 997
Query: 2871 VMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDP-----YSKAGKRLQNVV 2707
++L G+ L A ++ ++Q +DR PKI + K+L N+
Sbjct: 998 SETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQILDRKPKIQSPMGTIKNTLAKQL-NLF 1056
Query: 2706 GRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAG 2527
V++ + FRYP+R DAKILNGL+L V G +VALVGHSGCGKST V LL R Y+P+ G
Sbjct: 1057 EGVRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEG 1116
Query: 2526 NVTIDGTDVR-ELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEV---CK 2359
+ ID D++ +L ++ +R +GIV QEP LF +I N+ G+ +M+E+ K
Sbjct: 1117 TIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGD-NRRSVSMVEIIAAAK 1175
Query: 2358 MANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQS 2179
ANAH FI +P GYDT +G G QLSGGQKQR+AIAR L+R+PK+LLLDEATSALD QS
Sbjct: 1176 SANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQS 1235
Query: 2178 ESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDL 1999
E +VQ AL+ A GRT I+IAHRLST++ AD I + G +VE GNH +L+ GG Y L
Sbjct: 1236 EQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLISQGGIYAKL 1295
Query: 1998 VKAQQ 1984
K Q+
Sbjct: 1296 HKTQK 1300
Score = 270 bits (689), Expect = 3e-70
Identities = 185/614 (30%), Positives = 301/614 (48%), Gaps = 39/614 (6%)
Frame = -1
Query: 1734 YLDIFK-NAKGNYLYMFLGTVFALIRGLELPALALIFGW--------------------- 1621
+L +F+ + G ++F G + I+ L LPA+ +I+
Sbjct: 33 FLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIYSEFTSMLVDRAMQFGTSSNVHAL 92
Query: 1620 -VFEGFTFVPYGGRMMHRMAMAV------IAFASVGVGVWFSQLASSVLFAVVSENLSMR 1462
+F G + R + A+ I V ++ S + S +F +V+ R
Sbjct: 93 PLFGGGKTLTNASREENNEALYDDSISYGILLTIASVVMFISGIFSVDVFNMVALRQVTR 152
Query: 1461 FRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXX 1282
R++ F +++ QD + D + + D I+ + ++
Sbjct: 153 MRIKLFSSVIRQDIGWHDLASKQ--NFTQSMVDDVEKIRDGISEKVGHFVYLVVGFIITV 210
Query: 1281 XXXXIYCWQXXXXXXXXXXXLAFVMIGLA-YKISLMNVEQIQNDDAGRIAIEIIENVKTI 1105
Y W+ + + +A ++ L EQ AG +A EI+ +++T+
Sbjct: 211 AISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILSSIRTV 270
Query: 1104 QLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQG 925
+ Y+ +++ KG ++ ++ +S +Y + G+ +I
Sbjct: 271 VSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNLIIDD 330
Query: 924 DKSSDDTFKGIIAMM------LGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDL 763
+ + I M+ +GA + +A + F A+ A LF +I + L
Sbjct: 331 RNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFASARGCATNLFKVIDLTSKIDPL 390
Query: 762 MEGDRP---EIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNI 592
+ +RG++ F++V F YP RP + +GL GQTVALVG SG GKST +
Sbjct: 391 STDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCV 450
Query: 591 GMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGLKDVPL 412
+L+RFYD G++ +D DIRK ++ LR+ +A+VGQEP LF GTI +N+ G
Sbjct: 451 QLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQ 510
Query: 411 EKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEA 232
++I A A A+ F+ NLP + +GE+G QLSGGQKQRIAIARAL+++PKILLLDEA
Sbjct: 511 KEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEA 570
Query: 231 TSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMH 52
TSALD +SE+ VQ+ALD A +GRT I ++HRLS+I+ +D IV+I GKV E G+H LM
Sbjct: 571 TSALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMA 630
Query: 51 QKGRYYKLIKKQDL 10
+G YY +++ D+
Sbjct: 631 LEGAYYNMVRAGDI 644
>gi|15217809|ref|NP_174122.1| multidrug resistance P-glycoprotein,
putative [Arabidopsis thaliana]
gi|25297457|pir||F86405 probable P-glycoprotein [imported] -
Arabidopsis thaliana
gi|12322986|gb|AAG51476.1| P-glycoprotein, putative [Arabidopsis
thaliana]
Length = 1247
Score = 643 bits (1659), Expect = 0.0
Identities = 398/1261 (31%), Positives = 644/1261 (50%), Gaps = 14/1261 (1%)
Frame = -1
Query: 3744 QQLEAQPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTS 3565
++++ + VS+ GLF DY L+F+G + I G + P+ + G + ++L
Sbjct: 24 KKMKKESVSLMGLFSAADNVDYFLMFLGGLGTCIHGGTLPLFFVFFGGMLDSLGKLSTDP 83
Query: 3564 KQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFD 3385
++ ++N + +G+ ++ +I C+ R A++R ++ S+L ++ +FD
Sbjct: 84 NAISSRVSQNALYLVYLGLVNLVSAWIGVACWMQTGERQTARLRINYLKSILAKDITFFD 143
Query: 3384 KN-HSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAP 3208
++ +++ IGDK G +LR IA V+ ++ W+L + LGV P
Sbjct: 144 TEARDSNFIFHISSDAILVQDAIGDKTGHVLRYLCQFIAGFVIGFLSVWQLTLLTLGVVP 203
Query: 3207 TCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEK 3028
I A M++ + K AG +AEE + VRTV AF G+E+ V Y L+K
Sbjct: 204 LIAIAGGGYAIVMSTISEKSEAAYADAGKVAEEVMSQVRTVYAFVGEEKAVKSYSNSLKK 263
Query: 3027 GRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGA 2848
K + Y + L++ G T F +++++
Sbjct: 264 ALKLSKRSGLAKGLGVGLTYSLLFCAWALLFWYASLLVRHGK-TNGAKAFTTILNVIYSG 322
Query: 2847 YFLGLISPHMMVLLNARVSAASIYQTI-DRVPKIDPYSKAGKRLQNVVGRVKFENVHFRY 2671
+ LG P + + RV+AA+I++ I + + + G LQNVVG+++F V F Y
Sbjct: 323 FALGQAVPSLSAISKGRVAAANIFKMIGNNNLESSERLENGTTLQNVVGKIEFCGVSFAY 382
Query: 2670 PSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVREL 2491
PSR + + L+ + G + A VG SG GKST + ++ R YEP +G + +DG D++ L
Sbjct: 383 PSRPNM-VFENLSFTIHSGKTFAFVGPSGSGKSTIISMVQRFYEPRSGEILLDGNDIKNL 441
Query: 2490 NIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYD 2311
++WLR +G+V QEP LF TI +N+L+G + + +IE K ANA FI+ +P GY+
Sbjct: 442 KLKWLREQMGLVSQEPALFATTIASNILLGKEKANMDQIIEAAKAANADSFIKSLPNGYN 501
Query: 2310 TLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRT 2131
T +G+GG QLSGGQKQR+AIAR ++R+PK+LLLDEATSALDA+SE IVQ AL+N + RT
Sbjct: 502 TQVGEGGTQLSGGQKQRIAIARAVLRNPKILLLDEATSALDAESEKIVQQALDNVMEKRT 561
Query: 2130 TIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKADPXXXXXX 1951
TI+IAHRLSTIR DKIV G + E G+H EL+ GG Y LV Q D
Sbjct: 562 TIVIAHRLSTIRNVDKIVVLRDGQVRETGSHSELISRGGDYATLVNCQ----DTEPQENL 617
Query: 1950 XXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXXXXXXXXXXX 1771
+ + + +FR + S +
Sbjct: 618 RSVMYESCRSQAGSYSSRRVFSSRRTSSFREDQEKTEKDSKGEDLISS------------ 665
Query: 1770 XXXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPY 1591
++ ++ K +LY LG++ A++ G + ++ +V F + P+
Sbjct: 666 ---------SSMIWELIKLNAPEWLYALLGSIGAVLAGSQPALFSMGLAYVLTTF-YSPF 715
Query: 1590 GGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYF 1411
+ + I F G+ + + ++ E L+ R R+ F +L + +F
Sbjct: 716 PSLIKREVDKVAIIFVGAGIVTAPIYILQHYFYTLMGERLTSRVRLSLFSAILSNEIGWF 775
Query: 1410 DNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXX 1231
D + G L + LA+DA +++ + R+ + Y W+
Sbjct: 776 DLDENNTGSLTSILAADATLVRSAIADRLSTIVQNLSLTITALALAFFYSWR-----VAA 830
Query: 1230 XXXLAFVMIGLAYKISLMNVEQIQND------DAGRIAIEIIENVKTIQLLTRCELFFDH 1069
F ++ A + ++ D A +A E I N++T+ + + +
Sbjct: 831 VVTACFPLLIAASLTEQLFLKGFGGDYTRAYSRATSLAREAISNIRTVAAFSAEKQISEQ 890
Query: 1068 YQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGI----RIIYQGDKSSDDTF 901
+ + +S L +G I Y L+Q + +YA+G+ +I + + + +D+
Sbjct: 891 FTCELSKPTKSALLRGHISGFGYGLSQCLAF----CSYALGLWYISVLIKRNETNFEDSI 946
Query: 900 KGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLMEGDR--PEIRGNI 727
K + +++ A +V + P+ VK A G +F +++R+ R I+G+I
Sbjct: 947 KSFMVLLVTAYSVAETLALTPDIVKGTQALGSVFRVLHRETEIPPDQPNSRLVTHIKGDI 1006
Query: 726 LFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALR 547
F NV F+YP RP I K L G+++A+VGPSGSGKST IG++ RFYD + G L
Sbjct: 1007 EFRNVSFAYPTRPEIAIFKNLNLRVSAGKSLAVVGPSGSGKSTVIGLIMRFYDPSNGNLC 1066
Query: 546 IDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGLKDVPLEKINQALELANANRF 367
IDG DI+ ++L LR ++ALV QEP LF+ +I EN+ G ++ +I +A + ANA+ F
Sbjct: 1067 IDGHDIKSVNLRSLRKKLALVQQEPALFSTSIHENIKYGNENASEAEIIEAAKAANAHEF 1126
Query: 366 LANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEA 187
++ + G T VG+KG QLSGGQKQR+AIARA+++DP +LLLDEATSALD+ +E+ VQEA
Sbjct: 1127 ISRMEEGYMTHVGDKGVQLSGGQKQRVAIARAVLKDPSVLLLDEATSALDTSAEKQVQEA 1186
Query: 186 LDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQDLA 7
LD+ +GRT I +AHRLS+I+ +D IV + KGKV E G+H +L+ + +YK + A
Sbjct: 1187 LDKLMKGRTTILVAHRLSTIRKADTIVVLHKGKVVEKGSHRELVSKSDGFYKKLTSLQEA 1246
Query: 6 V 4
V
Sbjct: 1247 V 1247
>gi|15234322|ref|NP_192091.1| multidrug resistance P-glycoprotein,
putative [Arabidopsis thaliana]
gi|25297452|pir||D85023 P-glycoprotein-like protein pgp3 [imported] -
Arabidopsis thaliana
gi|4558551|gb|AAD22644.1| P-glycoprotein-like protein [Arabidopsis
thaliana]
gi|7268566|emb|CAB80675.1| P-glycoprotein-like protein pgp3
[Arabidopsis thaliana]
Length = 1229
Score = 642 bits (1656), Expect = 0.0
Identities = 394/1251 (31%), Positives = 658/1251 (52%), Gaps = 26/1251 (2%)
Frame = -1
Query: 3708 LFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKANENV- 3532
LF + D LL+ +G+I AI +GV P++ L+ G + +++ +N++N+++
Sbjct: 13 LFSFSDSTDVLLMIVGSIGAIGNGVGFPLMTLLFGDLIDSI---------GQNQSNKDIV 63
Query: 3531 ---------YIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFD-K 3382
+++LG+G + F+Q C+ R A++R ++ ++LRQ+ G+FD +
Sbjct: 64 EIVSKVCLKFVYLGLGTLGAA--FLQVACWMITGERQAARIRSLYLKTILRQDIGFFDVE 121
Query: 3381 NHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTC 3202
+G + +++ I E +G+K+G ++ A + V+A++ W L +ML P
Sbjct: 122 TSTGEVVGRMSGDTVLILEAMGEKVGKFIQLIATFVGGFVLAFVKGWLLTLVMLVSIPLL 181
Query: 3201 CICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGR 3022
I + + +T + +E KA ++ E++L +RTV +F G+++ + Y +
Sbjct: 182 AIAGAAMPIIVTRASSREQAAYAKASTVVEQTLGSIRTVASFTGEKQAMKSYREFINLAY 241
Query: 3021 KFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGA-YLLKVGIITTPGDVFIVVMSMLLGAY 2845
+ +V + + +G +LK G T G+V V+++++ +
Sbjct: 242 RASVKQGFSMGLGLGVVFFVFFCSYALAIWFGGEMILKKGY--TGGEVVNVMVTVVASSM 299
Query: 2844 FLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPS 2665
LG +P + + +A +++TI+R P ID + GK L+++ G ++ +V F YP+
Sbjct: 300 SLGQTTPCLTAFAAGKAAAYKMFETIERKPSIDAFDLNGKVLEDIRGEIELRDVCFSYPA 359
Query: 2664 RKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNI 2485
R ++ G +L++ G + ALVG SG GKS+ + L+ R Y+P +G+V IDG +++E +
Sbjct: 360 RPMEEVFGGFSLLIPSGATAALVGESGSGKSSVISLIERFYDPSSGSVLIDGVNLKEFQL 419
Query: 2484 EWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYDTL 2305
+W+R +G+V QEP+LF+ +I N+ G +T E + K+ANA +FI+K+P+G +TL
Sbjct: 420 KWIRGKIGLVSQEPVLFSSSIMENIGYGKENATVEEIQAAAKLANAANFIDKLPRGLETL 479
Query: 2304 IGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTI 2125
+G+ G QLSGGQKQR+AIAR +++DP++LLLDEATSALDA+SE +VQ AL+ RTT+
Sbjct: 480 VGEHGTQLSGGQKQRIAIARAILKDPRILLLDEATSALDAESERVVQEALDRVMMSRTTV 539
Query: 2124 MIAHRLSTIREADKIVFFEKGVIVEAGNHEELVR-LGGRYFDLVKAQQFKADPXXXXXXX 1948
++AHRLST+R AD I +G IVE G+H EL++ G Y L++ Q+ K +P
Sbjct: 540 IVAHRLSTVRNADMIAVIHRGKIVEEGSHSELLKDHEGAYAQLIRLQKIKKEPKRLESSN 599
Query: 1947 XXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXXXXXXXXXXXX 1768
+L D + RG+S N
Sbjct: 600 ----ELRD-----------------RSINRGSSRN--IRTRVHDDDSVSVLGLLGRQENT 636
Query: 1767 XXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYG 1588
+ I K + LGT+ + G P ++F V E F P+
Sbjct: 637 EISREQSRNVSITRIAALNKPETTILILGTLLGAVNGTIFPIFGILFAKVIEAFFKPPHD 696
Query: 1587 GRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFD 1408
+ R + F +GV + LFAV L R RV F +++ + +FD
Sbjct: 697 MKRDSRFWSMI--FVLLGVASLIVYPMHTYLFAVAGGRLIQRIRVMCFEKVVHMEVGWFD 754
Query: 1407 NPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXX 1228
+P ++ G + +RL++DA IK +V + W+
Sbjct: 755 DPENSSGTIGSRLSADAALIKTLVGDSLSLSVKNAAAAVSGLIIAFTASWK--------L 806
Query: 1227 XXLAFVMIGLAYKISLMNVEQIQN---------DDAGRIAIEIIENVKTIQLLTRCELFF 1075
+ VMI L + ++ I+ ++A ++A + + +++T+ E
Sbjct: 807 AVIILVMIPLIGINGYLQIKFIKGFTADAKAKYEEASQVANDAVGSIRTVASFCAEEKVM 866
Query: 1074 DHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKG 895
+ Y+ + +S +K+G+I + + ++ +Y + + VG R++ G + +D F+
Sbjct: 867 EMYKKRCEDTIKSGIKQGLISGVGFGISFFVLYSVYASCFYVGARLVKAGRTNFNDVFQV 926
Query: 894 IIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLMEGD--RPEIRGNILF 721
+A+ + A+ + ++ + P+ KAK AA +F II K E ++G+I
Sbjct: 927 FLALTMTAIGISQASSFAPDSSKAKGAAASIFGIIDGKSMIDSRDESGLVLENVKGDIEL 986
Query: 720 ENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRID 541
++ F+Y RP I + L + GQTVALVG SGSGKST I +L+RFYD G + +D
Sbjct: 987 CHISFTYQTRPDVQIFRDLCFAIRAGQTVALVGESGSGKSTVISLLQRFYDPDSGHITLD 1046
Query: 540 GQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGL--KDVPLEKINQALELANANRF 367
+++KL L +R QM LVGQEP LF TIR N+ G + +I A ELANA+ F
Sbjct: 1047 RVELKKLQLKWVRQQMGLVGQEPVLFNDTIRSNIAYGKGGDEASEAEIIAAAELANAHGF 1106
Query: 366 LANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEA 187
++++ G DT VGE+G QLSGGQKQR+AIARA+V++PKILLLDEATSALD+ESER VQ+A
Sbjct: 1107 ISSIQQGYDTVVGERGIQLSGGQKQRVAIARAIVKEPKILLLDEATSALDAESERVVQDA 1166
Query: 186 LDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYY 34
LDR RT + +AHRLS+I+N+D+I + G + E G H L++ +G Y
Sbjct: 1167 LDRVMVNRTTVVVAHRLSTIKNADVIAVVKNGVIVEKGTHETLINIEGGVY 1217
Score = 333 bits (854), Expect = 2e-89
Identities = 194/566 (34%), Positives = 316/566 (55%), Gaps = 5/566 (0%)
Frame = -1
Query: 3675 LLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKANENVYIFLGIGIFISI 3496
+L +GT+ ++G PI ++ +V A PP + ++ +++ LG+ I
Sbjct: 661 ILILGTLLGAVNGTIFPIFGILFAKVIEAFFK-PPHDMKRDSRFWSMIFVLLGVASLIVY 719
Query: 3495 TNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFD--KNHSGTITTKLNDSMERIREG 3322
+ F R++ ++R V+ GWFD +N SGTI ++L+ I+
Sbjct: 720 P--MHTYLFAVAGGRLIQRIRVMCFEKVVHMEVGWFDDPENSSGTIGSRLSADAALIKTL 777
Query: 3321 IGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELI 3142
+GD L + ++ A ++ +++A+ W+LA ++L + P I L + + T
Sbjct: 778 VGDSLSLSVKNAAAAVSGLIIAFTASWKLAVIILVMIPLIGINGYLQIKFIKGFTADAKA 837
Query: 3141 GVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXX 2962
+A +A +++ +RTV +F +E+++ Y+ E K + +
Sbjct: 838 KYEEASQVANDAVGSIRTVASFCAEEKVMEMYKKRCEDTIKSGIKQGLISGVGFGISFFV 897
Query: 2961 XXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAAS 2782
GA L+K G T DVF V +++ + A + S A+ +AAS
Sbjct: 898 LYSVYASCFYVGARLVKAGR-TNFNDVFQVFLALTMTAIGISQASSFAPDSSKAKGAAAS 956
Query: 2781 IYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVA 2602
I+ ID ID ++G L+NV G ++ ++ F Y +R D +I L + G +VA
Sbjct: 957 IFGIIDGKSMIDSRDESGLVLENVKGDIELCHISFTYQTRPDVQIFRDLCFAIRAGQTVA 1016
Query: 2601 LVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTI 2422
LVG SG GKST + LL R Y+P++G++T+D ++++L ++W+R +G+V QEP+LFNDTI
Sbjct: 1017 LVGESGSGKSTVISLLQRFYDPDSGHITLDRVELKKLQLKWVRQQMGLVGQEPVLFNDTI 1076
Query: 2421 HNNLLIGNPG--STRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIA 2248
+N+ G G ++ +I ++ANAH FI + +GYDT++G+ G+QLSGGQKQRVAIA
Sbjct: 1077 RSNIAYGKGGDEASEAEIIAAAELANAHGFISSIQQGYDTVVGERGIQLSGGQKQRVAIA 1136
Query: 2247 RTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFE 2068
R ++++PK+LLLDEATSALDA+SE +VQ AL+ RTT+++AHRLSTI+ AD I +
Sbjct: 1137 RAIVKEPKILLLDEATSALDAESERVVQDALDRVMVNRTTVVVAHRLSTIKNADVIAVVK 1196
Query: 2067 KGVIVEAGNHEELVRL-GGRYFDLVK 1993
GVIVE G HE L+ + GG Y LV+
Sbjct: 1197 NGVIVEKGTHETLINIEGGVYASLVQ 1222
Score = 279 bits (714), Expect = 3e-73
Identities = 181/573 (31%), Positives = 299/573 (51%), Gaps = 10/573 (1%)
Frame = -1
Query: 1698 LYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWF 1519
L M +G++ A+ G+ P + L+FG + + ++ ++ + F +G+G
Sbjct: 23 LLMIVGSIGAIGNGVGFPLMTLLFGDLIDSIGQNQSNKDIVEIVSKVCLKFVYLGLGTLG 82
Query: 1518 SQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAV 1339
+ + + E + R R + +L QD +FD + G+++ R++ D I
Sbjct: 83 AAFLQVACWMITGERQAARIRSLYLKTILRQDIGFFDVET-STGEVVGRMSGDTVLILEA 141
Query: 1338 VDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNV---E 1168
+ ++ + + W LA G A I + E
Sbjct: 142 MGEKVGKFIQLIATFVGGFVLAFVKGWLLTLVMLVSIPLLAIA--GAAMPIIVTRASSRE 199
Query: 1167 QIQNDDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQ 988
Q A + + + +++T+ T + Y+ R+ +K+G + L
Sbjct: 200 QAAYAKASTVVEQTLGSIRTVASFTGEKQAMKSYREFINLAYRASVKQGF----SMGLGL 255
Query: 987 SFMYFMMCFTYAVGI----RIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAK 820
++F+ +YA+ I +I + + + ++ ++ ++++ + F K
Sbjct: 256 GVVFFVFFCSYALAIWFGGEMILKKGYTGGEVVNVMVTVVASSMSLGQTTPCLTAFAAGK 315
Query: 819 TAAGMLFNIIYRKPRTG--DLMEGDRPEIRGNILFENVKFSYPQRPLQPIMKGLQWTALR 646
AA +F I RKP DL +IRG I +V FSYP RP++ + G
Sbjct: 316 AAAYKMFETIERKPSIDAFDLNGKVLEDIRGEIELRDVCFSYPARPMEEVFGGFSLLIPS 375
Query: 645 GQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRL 466
G T ALVG SGSGKS+ I ++ERFYD + G++ IDG ++++ L +R ++ LV QEP L
Sbjct: 376 GATAALVGESGSGKSSVISLIERFYDPSSGSVLIDGVNLKEFQLKWIRGKIGLVSQEPVL 435
Query: 465 FAGTIRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRI 286
F+ +I EN+ G ++ +E+I A +LANA F+ LP G++T VGE G QLSGGQKQRI
Sbjct: 436 FSSSIMENIGYGKENATVEEIQAAAKLANAANFIDKLPRGLETLVGEHGTQLSGGQKQRI 495
Query: 285 AIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIV 106
AIARA+++DP+ILLLDEATSALD+ESER VQEALDR RT + +AHRLS+++N+D+I
Sbjct: 496 AIARAILKDPRILLLDEATSALDAESERVVQEALDRVMMSRTTVIVAHRLSTVRNADMIA 555
Query: 105 YIDKGKVQEAGNHTQLM-HQKGRYYKLIKKQDL 10
I +GK+ E G+H++L+ +G Y +LI+ Q +
Sbjct: 556 VIHRGKIVEEGSHSELLKDHEGAYAQLIRLQKI 588
>gi|25455873|pir||T52319 P-glycoprotein-like protein pgp3 [imported] -
Arabidopsis thaliana
gi|2739309|emb|CAA75922.1| P-glycoprotein-like protein [Arabidopsis
thaliana]
Length = 1229
Score = 641 bits (1653), Expect = 0.0
Identities = 393/1251 (31%), Positives = 658/1251 (52%), Gaps = 26/1251 (2%)
Frame = -1
Query: 3708 LFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKANENV- 3532
LF + D LL+ +G+I AI +GV P++ L+ G + +++ +N++N+++
Sbjct: 13 LFSFSDSTDVLLMIVGSIGAIGNGVGFPLMTLLFGDLIDSI---------GQNQSNKDIV 63
Query: 3531 ---------YIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFD-K 3382
+++LG+G + F++ C+ R A++R ++ ++LRQ+ G+FD +
Sbjct: 64 EIVSKVCLKFVYLGLGTLGAA--FLEVACWMITGERQAARIRSLYLKTILRQDIGFFDVE 121
Query: 3381 NHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTC 3202
+G + +++ I E +G+K+G ++ A + V+A++ W L +ML P
Sbjct: 122 TSTGEVVGRMSGDTVLILEAMGEKVGKFIQLIATFVGGFVLAFVKGWLLTLVMLVSIPLL 181
Query: 3201 CICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGR 3022
I + + +T + +E KA ++ E++L +RTV +F G+++ + Y +
Sbjct: 182 AIAGAAMPIIVTRASSREQAAYAKASTVVEQTLGSIRTVASFTGEKQAMKSYREFINLAY 241
Query: 3021 KFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGA-YLLKVGIITTPGDVFIVVMSMLLGAY 2845
+ +V + + +G +LK G T G+V V+++++ +
Sbjct: 242 RASVKQGFSMGLGLGVVFFVFFCSYALAIWFGGEMILKKGY--TGGEVVNVMVTVVASSM 299
Query: 2844 FLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPS 2665
LG +P + + +A +++TI+R P ID + GK L+++ G ++ +V F YP+
Sbjct: 300 SLGQTTPCLTAFAAGKAAAYKMFETIERKPSIDAFDLNGKVLEDIRGEIELRDVCFSYPA 359
Query: 2664 RKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNI 2485
R ++ G +L++ G + ALVG SG GKS+ + L+ R Y+P +G+V IDG +++E +
Sbjct: 360 RPMEEVFGGFSLLIPSGATAALVGESGSGKSSVISLIERFYDPSSGSVLIDGVNLKEFQL 419
Query: 2484 EWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYDTL 2305
+W+R +G+V QEP+LF+ +I N+ G +T E + K+ANA +FI+K+P+G +TL
Sbjct: 420 KWIRGKIGLVSQEPVLFSSSIMENIGYGKENATVEEIQAAAKLANAANFIDKLPRGLETL 479
Query: 2304 IGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTI 2125
+G+ G QLSGGQKQR+AIAR +++DP++LLLDEATSALDA+SE +VQ AL+ RTT+
Sbjct: 480 VGEHGTQLSGGQKQRIAIARAILKDPRILLLDEATSALDAESERVVQEALDRVMMSRTTV 539
Query: 2124 MIAHRLSTIREADKIVFFEKGVIVEAGNHEELVR-LGGRYFDLVKAQQFKADPXXXXXXX 1948
++AHRLST+R AD I +G IVE G+H EL++ G Y L++ Q+ K +P
Sbjct: 540 IVAHRLSTVRNADMIAVIHRGKIVEEGSHSELLKDHEGAYAQLIRLQKIKKEPKRLESSN 599
Query: 1947 XXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXXXXXXXXXXXX 1768
+L D + RG+S N
Sbjct: 600 ----ELRD-----------------RSINRGSSRN--IRTRVHDDDSVSVLGLLGRQENT 636
Query: 1767 XXXEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYG 1588
+ I K + LGT+ + G P ++F V E F P+
Sbjct: 637 EISREQSRNVSITRIAALNKPETTILILGTLLGAVNGTIFPIFGILFAKVIEAFFKPPHD 696
Query: 1587 GRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFD 1408
+ R + F +GV + LFAV L R RV F +++ + +FD
Sbjct: 697 MKRDSRFWSMI--FVLLGVASLIVYPMHTYLFAVAGGRLIQRIRVMCFEKVVHMEVGWFD 754
Query: 1407 NPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXX 1228
+P ++ G + +RL++DA IK +V + W+
Sbjct: 755 DPENSSGTIGSRLSADAALIKTLVGDSLSLSVKNAAAAVSGLIIAFTASWK--------L 806
Query: 1227 XXLAFVMIGLAYKISLMNVEQIQN---------DDAGRIAIEIIENVKTIQLLTRCELFF 1075
+ VMI L + ++ I+ ++A ++A + + +++T+ E
Sbjct: 807 AVIILVMIPLIGINGYLQIKFIKGFTADAKAKYEEASQVANDAVGSIRTVASFCAEEKVM 866
Query: 1074 DHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKG 895
+ Y+ + +S +K+G+I + + ++ +Y + + VG R++ G + +D F+
Sbjct: 867 EMYKKRCEDTIKSGIKQGLISGVGFGISFFVLYSVYASCFYVGARLVKAGRTNFNDVFQV 926
Query: 894 IIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLMEGD--RPEIRGNILF 721
+A+ + A+ + ++ + P+ KAK AA +F II K E ++G+I
Sbjct: 927 FLALTMTAIGISQASSFAPDSSKAKGAAASIFGIIDGKSMIDSRDESGLVLENVKGDIEL 986
Query: 720 ENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRID 541
++ F+Y RP I + L + GQTVALVG SGSGKST I +L+RFYD G + +D
Sbjct: 987 CHISFTYQTRPDVQIFRDLCFAIRAGQTVALVGESGSGKSTVISLLQRFYDPDSGHITLD 1046
Query: 540 GQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGL--KDVPLEKINQALELANANRF 367
+++KL L +R QM LVGQEP LF TIR N+ G + +I A ELANA+ F
Sbjct: 1047 RVELKKLQLKWVRQQMGLVGQEPVLFNDTIRSNIAYGKGGDEASEAEIIAAAELANAHGF 1106
Query: 366 LANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEA 187
++++ G DT VGE+G QLSGGQKQR+AIARA+V++PKILLLDEATSALD+ESER VQ+A
Sbjct: 1107 ISSIQQGYDTVVGERGIQLSGGQKQRVAIARAIVKEPKILLLDEATSALDAESERVVQDA 1166
Query: 186 LDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYY 34
LDR RT + +AHRLS+I+N+D+I + G + E G H L++ +G Y
Sbjct: 1167 LDRVMVNRTTVVVAHRLSTIKNADVIAVVKNGVIVEKGTHETLINIEGGVY 1217
Score = 333 bits (854), Expect = 2e-89
Identities = 194/566 (34%), Positives = 316/566 (55%), Gaps = 5/566 (0%)
Frame = -1
Query: 3675 LLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKANENVYIFLGIGIFISI 3496
+L +GT+ ++G PI ++ +V A PP + ++ +++ LG+ I
Sbjct: 661 ILILGTLLGAVNGTIFPIFGILFAKVIEAFFK-PPHDMKRDSRFWSMIFVLLGVASLIVY 719
Query: 3495 TNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFD--KNHSGTITTKLNDSMERIREG 3322
+ F R++ ++R V+ GWFD +N SGTI ++L+ I+
Sbjct: 720 P--MHTYLFAVAGGRLIQRIRVMCFEKVVHMEVGWFDDPENSSGTIGSRLSADAALIKTL 777
Query: 3321 IGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELI 3142
+GD L + ++ A ++ +++A+ W+LA ++L + P I L + + T
Sbjct: 778 VGDSLSLSVKNAAAAVSGLIIAFTASWKLAVIILVMIPLIGINGYLQIKFIKGFTADAKA 837
Query: 3141 GVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXX 2962
+A +A +++ +RTV +F +E+++ Y+ E K + +
Sbjct: 838 KYEEASQVANDAVGSIRTVASFCAEEKVMEMYKKRCEDTIKSGIKQGLISGVGFGISFFV 897
Query: 2961 XXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAAS 2782
GA L+K G T DVF V +++ + A + S A+ +AAS
Sbjct: 898 LYSVYASCFYVGARLVKAGR-TNFNDVFQVFLALTMTAIGISQASSFAPDSSKAKGAAAS 956
Query: 2781 IYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVA 2602
I+ ID ID ++G L+NV G ++ ++ F Y +R D +I L + G +VA
Sbjct: 957 IFGIIDGKSMIDSRDESGLVLENVKGDIELCHISFTYQTRPDVQIFRDLCFAIRAGQTVA 1016
Query: 2601 LVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTI 2422
LVG SG GKST + LL R Y+P++G++T+D ++++L ++W+R +G+V QEP+LFNDTI
Sbjct: 1017 LVGESGSGKSTVISLLQRFYDPDSGHITLDRVELKKLQLKWVRQQMGLVGQEPVLFNDTI 1076
Query: 2421 HNNLLIGNPG--STRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIA 2248
+N+ G G ++ +I ++ANAH FI + +GYDT++G+ G+QLSGGQKQRVAIA
Sbjct: 1077 RSNIAYGKGGDEASEAEIIAAAELANAHGFISSIQQGYDTVVGERGIQLSGGQKQRVAIA 1136
Query: 2247 RTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFE 2068
R ++++PK+LLLDEATSALDA+SE +VQ AL+ RTT+++AHRLSTI+ AD I +
Sbjct: 1137 RAIVKEPKILLLDEATSALDAESERVVQDALDRVMVNRTTVVVAHRLSTIKNADVIAVVK 1196
Query: 2067 KGVIVEAGNHEELVRL-GGRYFDLVK 1993
GVIVE G HE L+ + GG Y LV+
Sbjct: 1197 NGVIVEKGTHETLINIEGGVYASLVQ 1222
Score = 279 bits (714), Expect = 3e-73
Identities = 181/573 (31%), Positives = 299/573 (51%), Gaps = 10/573 (1%)
Frame = -1
Query: 1698 LYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWF 1519
L M +G++ A+ G+ P + L+FG + + ++ ++ + F +G+G
Sbjct: 23 LLMIVGSIGAIGNGVGFPLMTLLFGDLIDSIGQNQSNKDIVEIVSKVCLKFVYLGLGTLG 82
Query: 1518 SQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAV 1339
+ + + E + R R + +L QD +FD + G+++ R++ D I
Sbjct: 83 AAFLEVACWMITGERQAARIRSLYLKTILRQDIGFFDVET-STGEVVGRMSGDTVLILEA 141
Query: 1338 VDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNV---E 1168
+ ++ + + W LA G A I + E
Sbjct: 142 MGEKVGKFIQLIATFVGGFVLAFVKGWLLTLVMLVSIPLLAIA--GAAMPIIVTRASSRE 199
Query: 1167 QIQNDDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQ 988
Q A + + + +++T+ T + Y+ R+ +K+G + L
Sbjct: 200 QAAYAKASTVVEQTLGSIRTVASFTGEKQAMKSYREFINLAYRASVKQGF----SMGLGL 255
Query: 987 SFMYFMMCFTYAVGI----RIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAK 820
++F+ +YA+ I +I + + + ++ ++ ++++ + F K
Sbjct: 256 GVVFFVFFCSYALAIWFGGEMILKKGYTGGEVVNVMVTVVASSMSLGQTTPCLTAFAAGK 315
Query: 819 TAAGMLFNIIYRKPRTG--DLMEGDRPEIRGNILFENVKFSYPQRPLQPIMKGLQWTALR 646
AA +F I RKP DL +IRG I +V FSYP RP++ + G
Sbjct: 316 AAAYKMFETIERKPSIDAFDLNGKVLEDIRGEIELRDVCFSYPARPMEEVFGGFSLLIPS 375
Query: 645 GQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRL 466
G T ALVG SGSGKS+ I ++ERFYD + G++ IDG ++++ L +R ++ LV QEP L
Sbjct: 376 GATAALVGESGSGKSSVISLIERFYDPSSGSVLIDGVNLKEFQLKWIRGKIGLVSQEPVL 435
Query: 465 FAGTIRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRI 286
F+ +I EN+ G ++ +E+I A +LANA F+ LP G++T VGE G QLSGGQKQRI
Sbjct: 436 FSSSIMENIGYGKENATVEEIQAAAKLANAANFIDKLPRGLETLVGEHGTQLSGGQKQRI 495
Query: 285 AIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIV 106
AIARA+++DP+ILLLDEATSALD+ESER VQEALDR RT + +AHRLS+++N+D+I
Sbjct: 496 AIARAILKDPRILLLDEATSALDAESERVVQEALDRVMMSRTTVIVAHRLSTVRNADMIA 555
Query: 105 YIDKGKVQEAGNHTQLM-HQKGRYYKLIKKQDL 10
I +GK+ E G+H++L+ +G Y +LI+ Q +
Sbjct: 556 VIHRGKIVEEGSHSELLKDHEGAYAQLIRLQKI 588
>gi|24324262|gb|AAN28720.2| MDR-like p-glycoprotein [Arabidopsis
thaliana]
Length = 1252
Score = 639 bits (1648), Expect = 0.0
Identities = 392/1241 (31%), Positives = 627/1241 (49%), Gaps = 10/1241 (0%)
Frame = -1
Query: 3708 LFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKANENVY 3529
LF + KFDYLL+F+G++ AI+ G S P+ L+ G++ N Q ++ +
Sbjct: 29 LFSFADKFDYLLMFVGSLGAIVHGSSMPVFFLLFGQMVNGFGKNQMDLHQMVHEVSRYSL 88
Query: 3528 IFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFDKN-HSGTITTKL 3352
F+ +G+ + +++ + C+ + R +A +R +++ +VL+Q+ G+FD + +G I +
Sbjct: 89 YFVYLGLVVCFSSYAEIACWMYSGERQVAALRKKYLEAVLKQDVGFFDTDARTGDIVFSV 148
Query: 3351 NDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQ 3172
+ +++ I +K+G + + +A +VV ++ W+LA + + V P L A
Sbjct: 149 STDTLLVQDAISEKVGNFIHYLSTFLAGLVVGFVSAWKLALLSVAVIPGIAFAGGLYAYT 208
Query: 3171 MTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXX 2992
+T T K AG IAE+++ VRTV ++ G+ + + Y ++ K
Sbjct: 209 LTGITSKSRESYANAGVIAEQAIAQVRTVYSYVGESKALNAYSDAIQYTLKLGYKAGMAK 268
Query: 2991 XXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMV 2812
Y ++ G T G F + S ++G LG ++
Sbjct: 269 GLGLGCTYGIACMSWALVFWYAGVFIRNGQ-TDGGKAFTAIFSAIVGGMSLGQSFSNLGA 327
Query: 2811 LLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLN 2632
+ + + + I++ P I GK L V G ++F++V F YPSR D I N
Sbjct: 328 FSKGKAAGYKLMEIINQRPTIIQDPLDGKCLDQVHGNIEFKDVTFSYPSRPDVMIFRNFN 387
Query: 2631 LVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQ 2452
+ G +VA+VG SG GKST V L+ R Y+P +G + +DG +++ L +++LR +G+V
Sbjct: 388 IFFPSGKTVAVVGGSGSGKSTVVSLIERFYDPNSGQILLDGVEIKTLQLKFLREQIGLVN 447
Query: 2451 QEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGG 2272
QEP LF TI N+L G P +T + ANAH FI +PKGYDT +G+ GVQLSGG
Sbjct: 448 QEPALFATTILENILYGKPDATMVEVEAAASAANAHSFITLLPKGYDTQVGERGVQLSGG 507
Query: 2271 QKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIRE 2092
QKQR+AIAR +++DPK+LLLDEATSALDA SESIVQ AL+ GRTT+++AHRL TIR
Sbjct: 508 QKQRIAIARAMLKDPKILLLDEATSALDASSESIVQEALDRVMVGRTTVVVAHRLCTIRN 567
Query: 2091 ADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKADPXXXXXXXXXEIDLDDTXXX 1912
D I ++G +VE G HEEL+ G Y L++ Q+ + T
Sbjct: 568 VDSIAVIQQGQVVETGTHEELIAKSGAYASLIRFQEM---------VGTRDFSNPSTRRT 618
Query: 1911 XXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXXXXXXXXXXXXXXXEDGQITAGY 1732
S + R G+ N S+S S + E+ +
Sbjct: 619 RSTRLSHSLSTKSLSLRSGSLRNLSYSYSTGADGRIEMISNAETDRKTRAPEN-----YF 673
Query: 1731 LDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVI 1552
+ K + Y +G V +++ G P A++ + E F + Y M + V
Sbjct: 674 YRLLKLNSPEWPYSIMGAVGSILSGFIGPTFAIVMSNMIEVFYYTDYDS-MERKTKEYVF 732
Query: 1551 AFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITR 1372
+ G+ + L F+++ ENL+ R R +L + +FD H + R
Sbjct: 733 IYIGAGLYAVGAYLIQHYFFSIMGENLTTRVRRMMLSAILRNEVGWFDEDEHNSSLIAAR 792
Query: 1371 LASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAY 1192
LA+DA ++K+ + R+ + I W+ F ++ LA
Sbjct: 793 LATDAADVKSAIAERISVILQNMTSLLTSFIVAFIVEWR-----VSLLILGTFPLLVLAN 847
Query: 1191 KISLMNVEQIQNDDA------GRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSEL 1030
++++ D A IA E + N++T+ + + ++ L
Sbjct: 848 FAQQLSLKGFAGDTAKAHAKTSMIAGEGVSNIRTVAAFNAQSKILSLFCHELRVPQKRSL 907
Query: 1029 KKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSA 850
+ + L+Q +Y G ++ +G + K + +++ A +V +
Sbjct: 908 YRSQTSGFLFGLSQLALYGSEALILWYGAHLVSKGVSTFSKVIKVFVVLVITANSVAETV 967
Query: 849 QYFPEFVKAKTAAGMLFNIIYRKPRTG-DLMEGDRPE-IRGNILFENVKFSYPQRPLQPI 676
PE ++ A G +F+++ R+ R D + D E IRG+I F +V F+YP RP +
Sbjct: 968 SLAPEIIRGGEAVGSVFSVLDRQTRIDPDDADADPVETIRGDIEFRHVDFAYPSRPDVMV 1027
Query: 675 MKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQ 496
+ G + ALVG SGSGKS+ I M+ERFYD+ G + IDG+DIR+L+L LR +
Sbjct: 1028 FRDFNLRIRAGHSQALVGASGSGKSSVIAMIERFYDLLAGKVMIDGKDIRRLNLKSLRLK 1087
Query: 495 MALVGQEPRLFAGTIRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGG 316
+ LV QEP LFA TI +N+ G ++ A ANA+ F++ LP G T VGE+G
Sbjct: 1088 IGLVQQEPALFAATIFDNIAYGKDGATESEVIDAARAANAHGFISGLPEGYKTPVGERGV 1147
Query: 315 QLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRL 136
QLSGGQKQRIAIARA++++P +LLLDEATSALD+ESE +QEAL+R GRT + +AHRL
Sbjct: 1148 QLSGGQKQRIAIARAVLKNPTVLLLDEATSALDAESECVLQEALERLMRGRTTVVVAHRL 1207
Query: 135 SSIQNSDLIVYIDKGKVQEAGNHTQLMHQ-KGRYYKLIKKQ 16
S+I+ D I I G++ E G+H++L+ + +G Y +L++ Q
Sbjct: 1208 STIRGVDCIGVIQDGRIVEQGSHSELVSRPEGAYSRLLQLQ 1248
Score = 305 bits (782), Expect = 4e-81
Identities = 200/575 (34%), Positives = 297/575 (50%), Gaps = 8/575 (1%)
Frame = -1
Query: 1710 KGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYG-GRMMHRMAMAVIAFASVG 1534
K +YL MF+G++ A++ G +P L+FG + GF +M+H ++ + F +G
Sbjct: 35 KFDYLLMFVGSLGAIVHGSSMPVFFLLFGQMVNGFGKNQMDLHQMVHEVSRYSLYFVYLG 94
Query: 1533 VGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAP 1354
+ V FS A + E R + +L QD +FD A G ++ +++D
Sbjct: 95 LVVCFSSYAEIACWMYSGERQVAALRKKYLEAVLKQDVGFFDTDART-GDIVFSVSTDTL 153
Query: 1353 NIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMN 1174
++ + ++ + W+ +AF G Y +L
Sbjct: 154 LVQDAISEKVGNFIHYLSTFLAGLVVGFVSAWKLALLSVAVIPGIAFA--GGLYAYTLTG 211
Query: 1173 VEQIQND---DAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAIN 1003
+ + +AG IA + I V+T+ + Y + + + K GM + +
Sbjct: 212 ITSKSRESYANAGVIAEQAIAQVRTVYSYVGESKALNAYSDAIQYTLKLGYKAGMAKGLG 271
Query: 1002 YSLTQSF--MYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFV 829
T M + + F YA G+ I G F I + ++G +++ S F
Sbjct: 272 LGCTYGIACMSWALVFWYA-GV-FIRNGQTDGGKAFTAIFSAIVGGMSLGQSFSNLGAFS 329
Query: 828 KAKTAAGMLFNIIYRKPRT-GDLMEGD-RPEIRGNILFENVKFSYPQRPLQPIMKGLQWT 655
K K A L II ++P D ++G ++ GNI F++V FSYP RP I +
Sbjct: 330 KGKAAGYKLMEIINQRPTIIQDPLDGKCLDQVHGNIEFKDVTFSYPSRPDVMIFRNFNIF 389
Query: 654 ALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQE 475
G+TVA+VG SGSGKST + ++ERFYD G + +DG +I+ L L LR Q+ LV QE
Sbjct: 390 FPSGKTVAVVGGSGSGKSTVVSLIERFYDPNSGQILLDGVEIKTLQLKFLREQIGLVNQE 449
Query: 474 PRLFAGTIRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQK 295
P LFA TI EN+ G D + ++ A ANA+ F+ LP G DT VGE+G QLSGGQK
Sbjct: 450 PALFATTILENILYGKPDATMVEVEAAASAANAHSFITLLPKGYDTQVGERGVQLSGGQK 509
Query: 294 QRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSD 115
QRIAIARA+++DPKILLLDEATSALD+ SE VQEALDR GRT + +AHRL +I+N D
Sbjct: 510 QRIAIARAMLKDPKILLLDEATSALDASSESIVQEALDRVMVGRTTVVVAHRLCTIRNVD 569
Query: 114 LIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQDL 10
I I +G+V E G H +L+ + G Y LI+ Q++
Sbjct: 570 SIAVIQQGQVVETGTHEELIAKSGAYASLIRFQEM 604
>gi|15217786|ref|NP_171754.1| multidrug resistance P-glycoprotein,
putative [Arabidopsis thaliana]
Length = 1273
Score = 639 bits (1647), Expect = 0.0
Identities = 402/1276 (31%), Positives = 652/1276 (50%), Gaps = 42/1276 (3%)
Frame = -1
Query: 3735 EAQPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQF 3556
+A+ V + LF + FD L+ G++ AI +GV P++ L+ G + ++ K
Sbjct: 24 KAKTVPLYKLFAFADSFDVFLMICGSLGAIGNGVCLPLMTLLFGDLIDSF------GKNQ 77
Query: 3555 RNKANENV-------YIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNA 3397
NK +V +++LG+G + F+Q C+ R A++R ++ ++LRQ+
Sbjct: 78 NNKDIVDVVSKVCLKFVYLGLGRLGAA--FLQVACWMITGERQAAKIRSNYLKTILRQDI 135
Query: 3396 GWFD-KNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMML 3220
G+FD + ++G + +++ I++ +G+K+G ++ + + +A+ W L +ML
Sbjct: 136 GFFDVETNTGEVVGRMSGDTVHIQDAMGEKVGKFIQLVSTFVGGFALAFAKGWLLTLVML 195
Query: 3219 GVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEA 3040
P + + +A +T + + KA ++ E+++ +RTV +F G+++ + Y+
Sbjct: 196 TSIPFLAMAGAAMALLVTRASSRGQAAYAKAATVVEQTIGSIRTVASFTGEKQAINSYKK 255
Query: 3039 ELEKGRKFAVWKXXXXXXXXXXXXXXXXXXXGCGMLYGA-YLLKVGIITTPGDVFIVVMS 2863
+ K ++ + + +G +L+ G T G V V++
Sbjct: 256 YITSAYKSSIQQGFSTGLGLGVMIYVFFSSYALAIWFGGKMILEKGY--TGGSVINVIII 313
Query: 2862 MLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENV 2683
++ G+ LG SP + + +A +++TI R P ID Y GK L ++ G ++ ++V
Sbjct: 314 VVAGSMSLGQTSPCVTAFAAGQAAAYKMFETIKRKPLIDAYDVNGKVLGDIRGDIELKDV 373
Query: 2682 HFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTD 2503
HF YP+R D +I +G +L + G + ALVG SG GKST + L+ R Y+P+AG V IDG +
Sbjct: 374 HFSYPARPDEEIFDGFSLFIPSGATAALVGESGSGKSTVINLIERFYDPKAGEVLIDGIN 433
Query: 2502 VRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMP 2323
++E ++W+R+ +G+V QEP+LF+ +I N+ G +T + + ++ANA FI +P
Sbjct: 434 LKEFQLKWIRSKIGLVCQEPVLFSSSIMENIAYGKENATLQEIKVATELANAAKFINNLP 493
Query: 2322 KGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNAS 2143
+G DT +G+ G QLSGGQKQR+AIAR +++DP+VLLLDEATSALD +SE +VQ AL+
Sbjct: 494 QGLDTKVGEHGTQLSGGQKQRIAIARAILKDPRVLLLDEATSALDTESERVVQEALDRVM 553
Query: 2142 KGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLG-GRYFDLVKAQQFKADPX 1966
RTT+++AHRLST+R AD I G +VE G+H EL++ G Y L++ Q+
Sbjct: 554 VNRTTVVVAHRLSTVRNADMIAVIHSGKMVEKGSHSELLKDSVGAYSQLIRCQEINKG-- 611
Query: 1965 XXXXXXXXEIDLDDTXXXXXXXXXXXXXXXSEAFRRGNSLN---DSFSGSKRSXXXXXXX 1795
D R G+ ++ SF S R
Sbjct: 612 ------------HDAKPSDMASGSSFRNSNLNISREGSVISGGTSSFGNSSRHHSLNVLG 659
Query: 1794 XXXXXXXXXXXXEDGQITAGYLD-----------IFKNAKGNYLYMFLGTVFALIRGLEL 1648
GQ G I K + LGTV A I G
Sbjct: 660 LFAGLDLGSGSQRVGQEETGTTSQEPLRKVSLTRIAALNKPEIPVLLLGTVVAAINGAIF 719
Query: 1647 PALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLS 1468
P ++ V E F F P ++ I F ++GV + LFAV L
Sbjct: 720 PLFGILISRVIEAF-FKP-ADQLKKDSRFWAIIFVALGVTSLIVSPSQMYLFAVAGGKLI 777
Query: 1467 MRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXX 1288
R + F ++ + S+FD P ++ G + RL++DA I+A+V +
Sbjct: 778 RRIQSMCFEKAVHMEVSWFDEPENSSGTMGARLSTDAALIRALVGDALSLAVQNAASAAS 837
Query: 1287 XXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQN---------DDAGRIA 1135
W+ + VM+ L + V+ ++ ++A ++A
Sbjct: 838 GLIIAFTASWE--------LALIILVMLPLIGINGFLQVKFMKGFSADAKSKYEEASQVA 889
Query: 1134 IEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTY 955
+ + +++T+ E Y + + +K+G I + + + ++ + ++
Sbjct: 890 NDAVGSIRTVASFCAEEKVMQMYNKQCEGPIKDGVKQGFISGLGFGFSFFILFCVYATSF 949
Query: 954 AVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPR 775
R++ G + D F+ A+ + A+ + S+ + P+ KAK AA +F II RK +
Sbjct: 950 YAAARLVEDGKTTFIDVFQVFFALTMAAIGISQSSTFAPDSSKAKVAAASIFAIIDRKSK 1009
Query: 774 ------TGDLMEGDRPEIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSG 613
TG ++E ++G+I ++ F+YP RP I + L T G+TVALVG SG
Sbjct: 1010 IDSSDETGTVLE----NVKGDIELRHLSFTYPARPGIQIFRDLCLTIRAGKTVALVGESG 1065
Query: 612 SGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCL 433
SGKST I +L+RFYD G + +DG +++KL L LR QM LVGQEP LF TIR N+
Sbjct: 1066 SGKSTVISLLQRFYDPDSGQITLDGVELKKLQLKWLRQQMGLVGQEPVLFNDTIRANIAY 1125
Query: 432 GL---KDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVR 262
G + +I A ELANA++F++++ G DT VGEKG QLSGGQKQR+AIARA+V+
Sbjct: 1126 GKGSEEAATESEIIAAAELANAHKFISSIQQGYDTVVGEKGIQLSGGQKQRVAIARAIVK 1185
Query: 261 DPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQ 82
+PKILLLDEATSALD+ESER VQ+ALDR RT + +AHRLS+I+N+D+I + G +
Sbjct: 1186 EPKILLLDEATSALDAESERLVQDALDRVIVNRTTVVVAHRLSTIKNADVIAIVKNGVIA 1245
Query: 81 EAGNHTQLMHQKGRYY 34
E G H L+ G Y
Sbjct: 1246 ENGTHETLIKIDGGVY 1261
Score = 336 bits (862), Expect = 2e-90
Identities = 198/567 (34%), Positives = 312/567 (54%), Gaps = 6/567 (1%)
Frame = -1
Query: 3675 LLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKANENVYIFLGIGIFISI 3496
+L +GT+ A I+G P+ ++ RV A + Q + + IF+ +G+ I
Sbjct: 704 VLLLGTVVAAINGAIFPLFGILISRVIEAFF---KPADQLKKDSRFWAIIFVALGVTSLI 760
Query: 3495 TNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFDK--NHSGTITTKLNDSMERIREG 3322
+ Q F +++ +++ + WFD+ N SGT+ +L+ IR
Sbjct: 761 VSPSQMYLFAVAGGKLIRRIQSMCFEKAVHMEVSWFDEPENSSGTMGARLSTDAALIRAL 820
Query: 3321 IGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELI 3142
+GD L + ++ A + +++A+ W LA ++L + P I L + M +
Sbjct: 821 VGDALSLAVQNAASAASGLIIAFTASWELALIILVMLPLIGINGFLQVKFMKGFSADAKS 880
Query: 3141 GVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXXXXXXXXXXXX 2962
+A +A +++ +RTV +F +E+++ Y + E K V +
Sbjct: 881 KYEEASQVANDAVGSIRTVASFCAEEKVMQMYNKQCEGPIKDGVKQGFISGLGFGFSFFI 940
Query: 2961 XXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAAS 2782
A L++ G TT DVF V ++ + A + S A+V+AAS
Sbjct: 941 LFCVYATSFYAAARLVEDGK-TTFIDVFQVFFALTMAAIGISQSSTFAPDSSKAKVAAAS 999
Query: 2781 IYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVA 2602
I+ IDR KID + G L+NV G ++ ++ F YP+R +I L L + G +VA
Sbjct: 1000 IFAIIDRKSKIDSSDETGTVLENVKGDIELRHLSFTYPARPGIQIFRDLCLTIRAGKTVA 1059
Query: 2601 LVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTI 2422
LVG SG GKST + LL R Y+P++G +T+DG ++++L ++WLR +G+V QEP+LFNDTI
Sbjct: 1060 LVGESGSGKSTVISLLQRFYDPDSGQITLDGVELKKLQLKWLRQQMGLVGQEPVLFNDTI 1119
Query: 2421 HNNLLIGN---PGSTRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAI 2251
N+ G +T +I ++ANAH FI + +GYDT++G+ G+QLSGGQKQRVAI
Sbjct: 1120 RANIAYGKGSEEAATESEIIAAAELANAHKFISSIQQGYDTVVGEKGIQLSGGQKQRVAI 1179
Query: 2250 ARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFF 2071
AR ++++PK+LLLDEATSALDA+SE +VQ AL+ RTT+++AHRLSTI+ AD I
Sbjct: 1180 ARAIVKEPKILLLDEATSALDAESERLVQDALDRVIVNRTTVVVAHRLSTIKNADVIAIV 1239
Query: 2070 EKGVIVEAGNHEELVRL-GGRYFDLVK 1993
+ GVI E G HE L+++ GG Y LV+
Sbjct: 1240 KNGVIAENGTHETLIKIDGGVYASLVQ 1266
Score = 288 bits (737), Expect = 7e-76
Identities = 182/569 (31%), Positives = 303/569 (52%), Gaps = 8/569 (1%)
Frame = -1
Query: 1692 MFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQ 1513
M G++ A+ G+ LP + L+FG + + F ++ ++ + F +G+G +
Sbjct: 45 MICGSLGAIGNGVCLPLMTLLFGDLIDSFGKNQNNKDIVDVVSKVCLKFVYLGLGRLGAA 104
Query: 1512 LASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVD 1333
+ + E + + R + +L QD +FD + G+++ R++ D +I+ +
Sbjct: 105 FLQVACWMITGERQAAKIRSNYLKTILRQDIGFFDVETNT-GEVVGRMSGDTVHIQDAMG 163
Query: 1332 ARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVE-QIQN 1156
++ + W LA +A ++ + Q
Sbjct: 164 EKVGKFIQLVSTFVGGFALAFAKGWLLTLVMLTSIPFLAMAGAAMALLVTRASSRGQAAY 223
Query: 1155 DDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMY 976
A + + I +++T+ T + + Y+ +S +++G + + M
Sbjct: 224 AKAATVVEQTIGSIRTVASFTGEKQAINSYKKYITSAYKSSIQQGFSTGLGLGV----MI 279
Query: 975 FMMCFTYAVGI----RIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAG 808
++ +YA+ I ++I + + II ++ G++++ ++ F + AA
Sbjct: 280 YVFFSSYALAIWFGGKMILEKGYTGGSVINVIIIVVAGSMSLGQTSPCVTAFAAGQAAAY 339
Query: 807 MLFNIIYRKPRTG--DLMEGDRPEIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTV 634
+F I RKP D+ +IRG+I ++V FSYP RP + I G G T
Sbjct: 340 KMFETIKRKPLIDAYDVNGKVLGDIRGDIELKDVHFSYPARPDEEIFDGFSLFIPSGATA 399
Query: 633 ALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGT 454
ALVG SGSGKST I ++ERFYD G + IDG ++++ L +R+++ LV QEP LF+ +
Sbjct: 400 ALVGESGSGKSTVINLIERFYDPKAGEVLIDGINLKEFQLKWIRSKIGLVCQEPVLFSSS 459
Query: 453 IRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIAR 274
I EN+ G ++ L++I A ELANA +F+ NLP G+DT VGE G QLSGGQKQRIAIAR
Sbjct: 460 IMENIAYGKENATLQEIKVATELANAAKFINNLPQGLDTKVGEHGTQLSGGQKQRIAIAR 519
Query: 273 ALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDK 94
A+++DP++LLLDEATSALD+ESER VQEALDR RT + +AHRLS+++N+D+I I
Sbjct: 520 AILKDPRVLLLDEATSALDTESERVVQEALDRVMVNRTTVVVAHRLSTVRNADMIAVIHS 579
Query: 93 GKVQEAGNHTQLMHQK-GRYYKLIKKQDL 10
GK+ E G+H++L+ G Y +LI+ Q++
Sbjct: 580 GKMVEKGSHSELLKDSVGAYSQLIRCQEI 608
>gi|15228695|ref|NP_191774.1| multidrug resistant (MDR) ABC
transporter, putative [Arabidopsis thaliana]
gi|11277353|pir||T48007 P-glycoprotein homolog T17J13.110
[similarity] - Arabidopsis thaliana
gi|6899925|emb|CAB71875.1| P-glycoprotein-like proetin [Arabidopsis
thaliana]
Length = 1292
Score = 638 bits (1646), Expect = 0.0
Identities = 389/1245 (31%), Positives = 647/1245 (51%), Gaps = 16/1245 (1%)
Frame = -1
Query: 3708 LFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKANENVY 3529
LF + FD +L+ +GTI A+ +G+ PI+ ++ G V + + S +K +
Sbjct: 68 LFAFADSFDIILMILGTIGAVGNGLGFPIMTILFGDVID-VFGQNQNSSDVSDKIAKVAL 126
Query: 3528 IFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFD-KNHSGTITTKL 3352
F+ +G+ + +Q + R ++R ++ ++LRQ+ +FD + ++G + ++
Sbjct: 127 KFVYLGLGTLVAALLQVSGWMISGERQAGRIRSLYLQTILRQDIAFFDVETNTGEVVGRM 186
Query: 3351 NDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQ 3172
+ I++ +G+K+G ++ + I V+A+ W L +M+ P + + LA
Sbjct: 187 SGDTVLIQDAMGEKVGKAIQLVSTFIGGFVIAFTEGWLLTLVMVSSIPLLVMSGAALAIV 246
Query: 3171 MTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXX 2992
++ + KA + E+++ +RTV +F G+++ + Y L + V++
Sbjct: 247 ISKMASRGQTSYAKAAVVVEQTVGSIRTVASFTGEKQAISNYNKHLVSAYRAGVFEGAST 306
Query: 2991 XXXXXXXXXXXXXXXGCGMLYGA-YLLKVGIITTPGDVFIVVMSMLLGAYFLGLISPHMM 2815
+ YG +L+ G T G V I++ ++L G+ LG SP +
Sbjct: 307 GLGLGTLNIVIFCTYALAVWYGGKMILEKGY--TGGQVLIIIFAVLTGSMSLGQASPCLS 364
Query: 2814 VLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKILNGL 2635
+ +A +++ I R P+ID GK L ++ G ++ NV+F YP+R + +I G
Sbjct: 365 AFAAGQAAAYKMFEAIKRKPEIDASDTTGKVLDDIRGDIELNNVNFSYPARPEEQIFRGF 424
Query: 2634 NLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIV 2455
+L + G++VALVG SG GKST V L+ R Y+P++G V IDG +++E ++W+R+ +G+V
Sbjct: 425 SLSISSGSTVALVGQSGSGKSTVVSLIERFYDPQSGEVRIDGINLKEFQLKWIRSKIGLV 484
Query: 2454 QQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSG 2275
QEP+LF +I N+ G +T E + + ++ANA FI+K+P+G DT++G+ G QLSG
Sbjct: 485 SQEPVLFTSSIKENIAYGKENATVEEIRKATELANASKFIDKLPQGLDTMVGEHGTQLSG 544
Query: 2274 GQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIR 2095
GQKQR+A+AR +++DP++LLLDEATSALDA+SE IVQ AL+ RTT+++AHRLST+R
Sbjct: 545 GQKQRIAVARAILKDPRILLLDEATSALDAESERIVQEALDRIMVNRTTVVVAHRLSTVR 604
Query: 2094 EADKIVFFEKGVIVEAGNHEELVR-LGGRYFDLVKAQQFKADPXXXXXXXXXEIDLDDTX 1918
AD I +G IVE G+H EL+R G Y L++ Q+ D T
Sbjct: 605 NADMIAVIHQGKIVEKGSHSELLRDPEGAYSQLIRLQE----------------DTKQTE 648
Query: 1917 XXXXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXXXXXXXXXXXXXXXEDGQIT- 1741
+ R+ +SL+ S S S +D +++
Sbjct: 649 DSTDEQKLSMESMKRSSLRK-SSLSRSLSKRSSSFSMFGFPAGIDTNNEAIPEKDIKVST 707
Query: 1740 ------AGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGRM 1579
+ + K + LG++ A++ G+ LP ++ V + F P ++
Sbjct: 708 PIKEKKVSFFRVAALNKPEIPMLILGSIAAVLNGVILPIFGILISSVIKAFFKPP--EQL 765
Query: 1578 MHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPA 1399
I F +GV A ++ F++ L R R F ++ + +FD
Sbjct: 766 KSDTRFWAIIFMLLGVASMVVFPAQTIFFSIAGCKLVQRIRSMCFEKVVRMEVGWFDETE 825
Query: 1398 HAPGKLITRLASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXL 1219
++ G + RL++DA ++ +V + Q + WQ
Sbjct: 826 NSSGAIGARLSADAATVRGLVGDALAQTVQNLASVTAGLVIAFVASWQ-----LAFIVLA 880
Query: 1218 AFVMIGLAYKISLMNVEQIQND--DAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQ 1045
+IGL I + + D +A ++A + + +++T+ E Y+ +
Sbjct: 881 MLPLIGLNGYIYMKFMVGFSADAKEASQVANDAVGSIRTVASFCAEEKVMKMYKKKCEGP 940
Query: 1044 KRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVA 865
R+ +++G++ I + ++ ++ ++ G R++ G + D F+ A+ + AVA
Sbjct: 941 MRTGIRQGIVSGIGFGVSFFVLFSSYAASFYAGARLVDDGKTTFDSVFRVFFALTMAAVA 1000
Query: 864 VMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLMEGDR--PEIRGNILFENVKFSYPQR 691
+ S+ P+ KA AA +F +I R+ + E R ++G+I ++ F YP R
Sbjct: 1001 ISQSSSLSPDSSKASNAAASIFAVIDRESKIDPSDESGRVLDNVKGDIELRHISFKYPSR 1060
Query: 690 PLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLF 511
P I + L + G+T+ALVG SGSGKST I +L+RFYD G + +DG +I+ L L
Sbjct: 1061 PDVQIFQDLCLSIRAGKTIALVGESGSGKSTVIALLQRFYDPDSGQITLDGVEIKTLQLK 1120
Query: 510 HLRTQMALVGQEPRLFAGTIRENVCLGL-KDVPLEKINQALELANANRFLANLPAGIDTD 334
LR Q LV QEP LF TIR N+ G D +I A EL+NA+ F++ L G DT
Sbjct: 1121 WLRQQTGLVSQEPVLFNETIRANIAYGKGGDATETEIVSAAELSNAHGFISGLQQGYDTM 1180
Query: 333 VGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCI 154
VGE+G QLSGGQKQR+AIARA+V+DPK+LLLDEATSALD+ESER VQ+ALDR RT +
Sbjct: 1181 VGERGVQLSGGQKQRVAIARAIVKDPKVLLLDEATSALDAESERVVQDALDRVMVNRTTV 1240
Query: 153 TIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQK-GRYYKLIK 22
+AHRLS+I+N+D+I + G + E G H L++ K G Y L++
Sbjct: 1241 VVAHRLSTIKNADVIAVVKNGVIVEKGKHETLINIKDGVYASLVQ 1285
Score = 309 bits (792), Expect = 3e-82
Identities = 193/575 (33%), Positives = 311/575 (53%), Gaps = 13/575 (2%)
Frame = -1
Query: 1698 LYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWF 1519
+ M LGT+ A+ GL P + ++FG V + F + ++A + F +G+G
Sbjct: 78 ILMILGTIGAVGNGLGFPIMTILFGDVIDVFGQNQNSSDVSDKIAKVALKFVYLGLGTLV 137
Query: 1518 SQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAV 1339
+ L + + E + R R + +L QD ++FD + G+++ R++ D I+
Sbjct: 138 AALLQVSGWMISGERQAGRIRSLYLQTILRQDIAFFDVETNT-GEVVGRMSGDTVLIQDA 196
Query: 1338 VDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMNVEQIQ 1159
+ ++ + W VM G A I + +
Sbjct: 197 MGEKVGKAIQLVSTFIGGFVIAFTEGW--LLTLVMVSSIPLLVMSGAALAIVISKMASRG 254
Query: 1158 NDDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKR--SELKKGMIEAINYSLTQS 985
+ A+ + + V +I+ + F Q S K S + G+ E + L
Sbjct: 255 QTSYAKAAVVVEQTVGSIRTVAS---FTGEKQAISNYNKHLVSAYRAGVFEGASTGLGLG 311
Query: 984 FMYFMMCFTYAVGI----RIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKT 817
+ ++ TYA+ + ++I + + I A++ G++++ ++ F +
Sbjct: 312 TLNIVIFCTYALAVWYGGKMILEKGYTGGQVLIIIFAVLTGSMSLGQASPCLSAFAAGQA 371
Query: 816 AAGMLFNIIYRKPR------TGDLMEGDRPEIRGNILFENVKFSYPQRPLQPIMKGLQWT 655
AA +F I RKP TG +++ +IRG+I NV FSYP RP + I +G +
Sbjct: 372 AAYKMFEAIKRKPEIDASDTTGKVLD----DIRGDIELNNVNFSYPARPEEQIFRGFSLS 427
Query: 654 ALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQE 475
G TVALVG SGSGKST + ++ERFYD G +RIDG ++++ L +R+++ LV QE
Sbjct: 428 ISSGSTVALVGQSGSGKSTVVSLIERFYDPQSGEVRIDGINLKEFQLKWIRSKIGLVSQE 487
Query: 474 PRLFAGTIRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQK 295
P LF +I+EN+ G ++ +E+I +A ELANA++F+ LP G+DT VGE G QLSGGQK
Sbjct: 488 PVLFTSSIKENIAYGKENATVEEIRKATELANASKFIDKLPQGLDTMVGEHGTQLSGGQK 547
Query: 294 QRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSD 115
QRIA+ARA+++DP+ILLLDEATSALD+ESER VQEALDR RT + +AHRLS+++N+D
Sbjct: 548 QRIAVARAILKDPRILLLDEATSALDAESERIVQEALDRIMVNRTTVVVAHRLSTVRNAD 607
Query: 114 LIVYIDKGKVQEAGNHTQLMHQ-KGRYYKLIKKQD 13
+I I +GK+ E G+H++L+ +G Y +LI+ Q+
Sbjct: 608 MIAVIHQGKIVEKGSHSELLRDPEGAYSQLIRLQE 642
>gi|15228506|ref|NP_189528.1| multidrug resistance P-glycoprotein,
putative [Arabidopsis thaliana]
gi|9294227|dbj|BAB02129.1| P-glycoprotein; multi-drug resistance
related; ABC transporter-like protein [Arabidopsis
thaliana]
Length = 1252
Score = 638 bits (1645), Expect = 0.0
Identities = 392/1241 (31%), Positives = 626/1241 (49%), Gaps = 10/1241 (0%)
Frame = -1
Query: 3708 LFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKANENVY 3529
LF + KFDYLL+F+G++ AI+ G S P+ L+ G++ N Q ++ +
Sbjct: 29 LFSFADKFDYLLMFVGSLGAIVHGSSMPVFFLLFGQMVNGFGKNQMDLHQMVHEVSRYSL 88
Query: 3528 IFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFDKN-HSGTITTKL 3352
F+ +G+ + +++ + C+ + R +A +R +++ +VL+Q+ G+FD + +G I +
Sbjct: 89 YFVYLGLVVCFSSYAEIACWMYSGERQVAALRKKYLEAVLKQDVGFFDTDARTGDIVFSV 148
Query: 3351 NDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQ 3172
+ +++ I +K+G + + +A +VV ++ W+LA + + V P L A
Sbjct: 149 STDTLLVQDAISEKVGNFIHYLSTFLAGLVVGFVSAWKLALLSVAVIPGIAFAGGLYAYT 208
Query: 3171 MTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKXXXX 2992
+T T K AG IAE+++ VRTV ++ G+ + + Y ++ K
Sbjct: 209 LTGITSKSRESYANAGVIAEQAIAQVRTVYSYVGESKALNAYSDAIQYTLKLGYKAGMAK 268
Query: 2991 XXXXXXXXXXXXXXXGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMV 2812
Y ++ G T G F + S ++G LG ++
Sbjct: 269 GLGLGCTYGIACMSWALVFWYAGVFIRNGQ-TDGGKAFTAIFSAIVGGMSLGQSFSNLGA 327
Query: 2811 LLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLN 2632
+ + + + I++ P I GK L V G ++F++V F YPSR D I N
Sbjct: 328 FSKGKAAGYKLMEIINQRPTIIQDPLDGKCLDQVHGNIEFKDVTFSYPSRPDVMIFRNFN 387
Query: 2631 LVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQ 2452
+ G +VA+VG SG GKST V L+ R Y+P +G + +DG +++ L +++LR +G+V
Sbjct: 388 IFFPSGKTVAVVGGSGSGKSTVVSLIERFYDPNSGQILLDGVEIKTLQLKFLREQIGLVN 447
Query: 2451 QEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGG 2272
QEP LF TI N+L G P +T + ANAH FI +PKGYDT +G+ GVQLSGG
Sbjct: 448 QEPALFATTILENILYGKPDATMVEVEAAASAANAHSFITLLPKGYDTQVGERGVQLSGG 507
Query: 2271 QKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIRE 2092
QKQR+AIAR +++DPK+LLLDEATSALDA SESIVQ AL+ GRTT+++AHRL TIR
Sbjct: 508 QKQRIAIARAMLKDPKILLLDEATSALDASSESIVQEALDRVMVGRTTVVVAHRLCTIRN 567
Query: 2091 ADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKADPXXXXXXXXXEIDLDDTXXX 1912
D I ++G +VE G HEEL+ G Y L++ Q+ + T
Sbjct: 568 VDSIAVIQQGQVVETGTHEELIAKSGAYASLIRFQEM---------VGTRDFSNPSTRRT 618
Query: 1911 XXXXXXXXXXXXSEAFRRGNSLNDSFSGSKRSXXXXXXXXXXXXXXXXXXXEDGQITAGY 1732
S + R G+ N S+S S + E+ +
Sbjct: 619 RSTRLSHSLSTKSLSLRSGSLRNLSYSYSTGADGRIEMISNAETDRKTRAPEN-----YF 673
Query: 1731 LDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVI 1552
+ K + Y +G V +++ G P A++ + E F + Y M + V
Sbjct: 674 YRLLKLNSPEWPYSIMGAVGSILSGFIGPTFAIVMSNMIEVFYYTDYDS-MERKTKEYVF 732
Query: 1551 AFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITR 1372
+ G+ + L F+++ ENL+ R R +L + +FD H + R
Sbjct: 733 IYIGAGLYAVGAYLIQHYFFSIMGENLTTRVRRMMLSAILRNEVGWFDEDEHNSSLIAAR 792
Query: 1371 LASDAPNIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAY 1192
LA+DA ++K+ + R+ + I W+ F ++ LA
Sbjct: 793 LATDAADVKSAIAERISVILQNMTSLLTSFIVAFIVEWR-----VSLLILGTFPLLVLAN 847
Query: 1191 KISLMNVEQIQNDDA------GRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSEL 1030
++++ D A IA E + N++T+ + + ++ L
Sbjct: 848 FAQQLSLKGFAGDTAKAHAKTSMIAGEGVSNIRTVAAFNAQSKILSLFCHELRVPQKRSL 907
Query: 1029 KKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSA 850
+ + L+Q +Y G ++ +G + K + +++ A +V +
Sbjct: 908 YRSQTSGFLFGLSQLALYGSEALILWYGAHLVSKGVSTFSKVIKVFVVLVITANSVAETV 967
Query: 849 QYFPEFVKAKTAAGMLFNIIYRKPRTG-DLMEGDRPE-IRGNILFENVKFSYPQRPLQPI 676
PE ++ A G +F+++ R+ R D + D E IRG+I F +V F+YP RP +
Sbjct: 968 SLAPEIIRGGEAVGSVFSVLDRQTRIDPDDADADPVETIRGDIEFRHVDFAYPSRPDVMV 1027
Query: 675 MKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQ 496
+ G + ALVG SGSGKS+ I M+ERFYD G + IDG+DIR+L+L LR +
Sbjct: 1028 FRDFNLRIRAGHSQALVGASGSGKSSVIAMIERFYDPLAGKVMIDGKDIRRLNLKSLRLK 1087
Query: 495 MALVGQEPRLFAGTIRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGG 316
+ LV QEP LFA TI +N+ G ++ A ANA+ F++ LP G T VGE+G
Sbjct: 1088 IGLVQQEPALFAATIFDNIAYGKDGATESEVIDAARAANAHGFISGLPEGYKTPVGERGV 1147
Query: 315 QLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRL 136
QLSGGQKQRIAIARA++++P +LLLDEATSALD+ESE +QEAL+R GRT + +AHRL
Sbjct: 1148 QLSGGQKQRIAIARAVLKNPTVLLLDEATSALDAESECVLQEALERLMRGRTTVVVAHRL 1207
Query: 135 SSIQNSDLIVYIDKGKVQEAGNHTQLMHQ-KGRYYKLIKKQ 16
S+I+ D I I G++ E G+H++L+ + +G Y +L++ Q
Sbjct: 1208 STIRGVDCIGVIQDGRIVEQGSHSELVSRPEGAYSRLLQLQ 1248
Score = 305 bits (782), Expect = 4e-81
Identities = 200/575 (34%), Positives = 297/575 (50%), Gaps = 8/575 (1%)
Frame = -1
Query: 1710 KGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYG-GRMMHRMAMAVIAFASVG 1534
K +YL MF+G++ A++ G +P L+FG + GF +M+H ++ + F +G
Sbjct: 35 KFDYLLMFVGSLGAIVHGSSMPVFFLLFGQMVNGFGKNQMDLHQMVHEVSRYSLYFVYLG 94
Query: 1533 VGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAP 1354
+ V FS A + E R + +L QD +FD A G ++ +++D
Sbjct: 95 LVVCFSSYAEIACWMYSGERQVAALRKKYLEAVLKQDVGFFDTDART-GDIVFSVSTDTL 153
Query: 1353 NIKAVVDARMLQVXXXXXXXXXXXXXXXIYCWQXXXXXXXXXXXLAFVMIGLAYKISLMN 1174
++ + ++ + W+ +AF G Y +L
Sbjct: 154 LVQDAISEKVGNFIHYLSTFLAGLVVGFVSAWKLALLSVAVIPGIAFA--GGLYAYTLTG 211
Query: 1173 VEQIQND---DAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAIN 1003
+ + +AG IA + I V+T+ + Y + + + K GM + +
Sbjct: 212 ITSKSRESYANAGVIAEQAIAQVRTVYSYVGESKALNAYSDAIQYTLKLGYKAGMAKGLG 271
Query: 1002 YSLTQSF--MYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFV 829
T M + + F YA G+ I G F I + ++G +++ S F
Sbjct: 272 LGCTYGIACMSWALVFWYA-GV-FIRNGQTDGGKAFTAIFSAIVGGMSLGQSFSNLGAFS 329
Query: 828 KAKTAAGMLFNIIYRKPRT-GDLMEGD-RPEIRGNILFENVKFSYPQRPLQPIMKGLQWT 655
K K A L II ++P D ++G ++ GNI F++V FSYP RP I +
Sbjct: 330 KGKAAGYKLMEIINQRPTIIQDPLDGKCLDQVHGNIEFKDVTFSYPSRPDVMIFRNFNIF 389
Query: 654 ALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQE 475
G+TVA+VG SGSGKST + ++ERFYD G + +DG +I+ L L LR Q+ LV QE
Sbjct: 390 FPSGKTVAVVGGSGSGKSTVVSLIERFYDPNSGQILLDGVEIKTLQLKFLREQIGLVNQE 449
Query: 474 PRLFAGTIRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQK 295
P LFA TI EN+ G D + ++ A ANA+ F+ LP G DT VGE+G QLSGGQK
Sbjct: 450 PALFATTILENILYGKPDATMVEVEAAASAANAHSFITLLPKGYDTQVGERGVQLSGGQK 509
Query: 294 QRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSD 115
QRIAIARA+++DPKILLLDEATSALD+ SE VQEALDR GRT + +AHRL +I+N D
Sbjct: 510 QRIAIARAMLKDPKILLLDEATSALDASSESIVQEALDRVMVGRTTVVVAHRLCTIRNVD 569
Query: 114 LIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQDL 10
I I +G+V E G H +L+ + G Y LI+ Q++
Sbjct: 570 SIAVIQQGQVVETGTHEELIAKSGAYASLIRFQEM 604