Homology by BLASTX
BLASTX 2.2.4 [Aug-26-2002]
Query= F33D4_3
(8541 letters)
Database: /home/niguts/usr02/tshini/ykclst/db/nr.seq
1,967,186 sequences; 661,712,633 total letters
Score E
Sequences producing significant alignments: (bits) Value
gi|17541128|ref|NP_501252.1| inositol 1 4 5-Triphosphate Recepto... 5506 0.0
gi|25153695|ref|NP_501250.2| inositol 1 4 5-Triphosphate Recepto... 5479 0.0
gi|25153698|ref|NP_501251.2| inositol 1 4 5-Triphosphate Recepto... 5476 0.0
gi|14574164|gb|AAK68362.1| Inositol triphosphate receptor protei... 5471 0.0
gi|14574166|gb|AAK68364.1| Inositol triphosphate receptor protei... 5469 0.0
gi|17541126|ref|NP_501253.1| inositol 1 4 5-Triphosphate Recepto... 5454 0.0
gi|7500399|pir||T32550 hypothetical protein F33D4.2a - Caenorhab... 5417 0.0
gi|39593648|emb|CAE61940.1| Hypothetical protein CBG05938 [Caeno... 4989 0.0
gi|10636263|emb|CAC10528.1| putative inositol 1,4,5-trisphosphat... 4937 0.0
gi|7500401|pir||T32552 hypothetical protein F33D4.2c - Caenorhab... 3744 0.0
gi|14574165|gb|AAK68363.1| Inositol triphosphate receptor protei... 3600 0.0
gi|22532932|gb|AAM98028.1| Inositol triphosphate receptor protei... 3330 0.0
gi|10835023|ref|NP_002213.1| inositol 1,4,5-triphosphate recepto... 1658 0.0
gi|46107962|gb|AAB04947.2| inositol 1,4,5-trisphosphate receptor... 1654 0.0
gi|1362832|pir||A55713 inositol 1,4,5-triphosphate receptor type... 1640 0.0
gi|7522013|pir||T31431 inositol 1,4,5-trisphosphate receptor, lo... 1638 0.0
gi|4504793|ref|NP_002214.1| inositol 1,4,5-triphosphate receptor... 1623 0.0
gi|27805961|ref|NP_776794.1| inositol 1,4,5-triphosphate recepto... 1623 0.0
gi|13022060|gb|AAK11622.1| IP3 receptor isoform 2 [Rattus norveg... 1622 0.0
gi|13591975|ref|NP_112308.1| inositol 1,4,5-triphosphate recepto... 1622 0.0
gi|18307586|dbj|BAB84088.1| inositol 1,4,5-trisphosphate recepto... 1621 0.0
gi|27807313|ref|NP_777266.1| inositol 1,4,5-triphosphate recepto... 1612 0.0
gi|4504795|ref|NP_002215.1| inositol 1,4,5-triphosphate receptor... 1582 0.0
gi|17366458|sp|Q14573|IP3T_HUMAN Inositol 1,4,5-trisphosphate re... 1580 0.0
gi|6981110|ref|NP_037270.1| inositol 1, 4, 5-triphosphate recept... 1575 0.0
gi|27805963|ref|NP_776795.1| inositol 1,4,5-triphosphate recepto... 1570 0.0
gi|31217824|ref|XP_316515.1| ENSANGP00000004303 [Anopheles gambi... 1544 0.0
gi|50760465|ref|XP_418035.1| PREDICTED: similar to Inositol 1,4,... 1266 0.0
gi|476810|pir||A40743 IP3 receptor, XIP3R - African clawed frog ... 1235 0.0
gi|44888998|sp|P29993|IP3R_DROME Inositol 1,4,5-trisphosphate re... 1122 0.0
gi|24644261|ref|NP_730942.1| CG1063-PA [Drosophila melanogaster]... 1122 0.0
gi|24644259|ref|NP_730941.1| CG1063-PB [Drosophila melanogaster]... 1122 0.0
gi|5689748|emb|CAB51853.1| inositol 1,4,5-trisphosphate receptor... 1102 0.0
gi|345496|pir||A43360 inositol 1,4,5-trisphosphate receptor - fr... 1100 0.0
gi|111839|pir||B36579 inositol 1,4,5-triphosphate receptor 2 - r... 1060 0.0
gi|6754390|ref|NP_034715.1| inositol 1,4,5-triphosphate receptor... 1059 0.0
gi|34857738|ref|XP_342733.1| similar to Inositol 1,4,5-trisphosp... 1058 0.0
gi|17380349|sp|P29994|IP3R_RAT Inositol 1,4,5-trisphosphate rece... 1056 0.0
gi|111838|pir||A36579 inositol 1,4,5-triphosphate receptor 1 - r... 1056 0.0
gi|17366467|sp|Q14643|IP3R_HUMAN Inositol 1,4,5-trisphosphate re... 1055 0.0
gi|47219802|emb|CAG03429.1| unnamed protein product [Tetraodon n... 980 0.0
gi|50754604|ref|XP_414438.1| PREDICTED: similar to inositol 1,4,... 921 0.0
gi|47229530|emb|CAG06726.1| unnamed protein product [Tetraodon n... 910 0.0
gi|19388011|gb|AAH25805.1| Itpr5 protein [Mus musculus] 837 0.0
gi|47227347|emb|CAF96896.1| unnamed protein product [Tetraodon n... 747 0.0
gi|21362620|sp||Q9Z329_2 [Segment 2 of 2] Inositol 1,4,5-trispho... 666 0.0
gi|26339686|dbj|BAC33514.1| unnamed protein product [Mus musculus] 658 0.0
gi|47212327|emb|CAF91265.1| unnamed protein product [Tetraodon n... 626 e-177
gi|26324446|dbj|BAC25977.1| unnamed protein product [Mus musculus] 585 e-165
gi|48095094|ref|XP_392236.1| similar to CG1063-PB [Apis mellifera] 511 e-142
gi|50582469|dbj|BAD32702.1| LIBRA [synthetic construct] 480 e-133
gi|26326875|dbj|BAC27181.1| unnamed protein product [Mus musculus] 468 e-130
gi|46189240|gb|AAH68269.1| Unknown (protein for IMAGE:30024505) ... 414 e-113
gi|26324442|dbj|BAC25975.1| unnamed protein product [Mus musculus] 360 3e-97
gi|26348319|dbj|BAC37799.1| unnamed protein product [Mus musculus] 360 3e-97
gi|1196648|gb|AAA88319.1| putative >gnl|BL_ORD_ID|819024 gi|1309... 342 7e-92
gi|16307548|gb|AAH10323.1| Itpr3 protein [Mus musculus] 338 1e-90
gi|26338934|dbj|BAC33138.1| unnamed protein product [Mus musculus] 332 1e-88
gi|2119532|pir||I48607 inositol 1,4,5-trisphosphate receptor typ... 327 4e-87
gi|26336805|dbj|BAC32085.1| unnamed protein product [Mus musculus] 315 2e-83
gi|7848|emb|CAA79220.1| inositol 1,4, 5-triphosphate receptor [D... 311 2e-82
gi|477498|pir||A49131 inositol 1,4,5-triphosphate receptor Dip /... 307 3e-81
gi|27574053|pdb|1N4K|A Chain A, Crystal Structure Of The Inosito... 274 2e-71
gi|21362619|sp||Q9Z329_1 [Segment 1 of 2] Inositol 1,4,5-trispho... 257 3e-66
gi|11245468|gb|AAG33627.1| type I inositol triphosphate receptor... 207 4e-51
gi|1098969|gb|AAC53100.1| inositol 1,4,5-trisphosphate receptor 203 5e-50
gi|1495698|emb|CAA94862.1| inositol 1,4,5-trisphosphate receptor... 197 4e-48
gi|17366368|sp|P70227|IP3T_MOUSE Inositol 1,4,5-trisphosphate re... 197 4e-48
gi|3786318|dbj|BAA33961.1| inositol 1,4,5-trisphosphate receptor... 192 1e-46
gi|9910290|ref|NP_064307.1| inositol 1,4,5-triphosphate receptor... 192 1e-46
gi|50405284|ref|YP_054376.1| Inositol 1,4,5-triphosphate recepto... 178 2e-42
gi|1871447|dbj|BAA08309.1| ryanodine receptor [Caenorhabditis el... 139 2e-30
gi|17564924|ref|NP_504753.1| UNCoordinated locomotion UNC-68, Ke... 139 2e-30
gi|39594392|emb|CAE71970.1| Hypothetical protein CBG19042 [Caeno... 139 2e-30
gi|26335003|dbj|BAC31202.1| unnamed protein product [Mus musculus] 136 1e-29
gi|2809067|dbj|BAA24504.1| inositol 1,4,5-triphosphate recepter ... 132 2e-28
gi|7441639|pir||PC4441 inositol 1,4,5-triphosphate receptor - ho... 132 2e-28
gi|47221064|emb|CAG12758.1| unnamed protein product [Tetraodon n... 129 1e-27
gi|2108232|gb|AAB58117.1| [Prot=RyR1 isform from fish] Fish RyR1... 129 2e-27
gi|38086189|ref|XP_133347.2| similar to ryanodine receptor 1 (sk... 127 4e-27
gi|164429|gb|AAA31022.1| calcium release channel protein 126 1e-26
gi|1937|emb|CAA44674.1| calcium release channel [Sus scrofa] 126 1e-26
gi|226386|prf||1509336A ryanodine receptor 126 1e-26
gi|134134|sp|P11716|RYR1_RABIT Ryanodine receptor 1 (Skeletal mu... 126 1e-26
gi|1079342|pir||A54161 ryanodine-binding protein alpha form - bu... 126 1e-26
gi|2134400|pir||S66572 ryanodine receptor type 3 - chicken 126 1e-26
gi|46048744|ref|NP_996757.1| ryanodine receptor type 3 [Gallus g... 126 1e-26
gi|30109246|gb|AAH51248.1| Ryr1 protein [Mus musculus] 126 1e-26
gi|10863871|ref|NP_000531.1| ryanodine receptor 1 (skeletal); sa... 126 1e-26
gi|33585472|gb|AAH55487.1| Ryr1 protein [Mus musculus] 126 1e-26
gi|34855645|ref|XP_341819.1| ryanodine receptor 1 (skeletal) [Ra... 126 1e-26
gi|45597439|ref|NP_033135.1| ryanodine receptor 1, skeletal musc... 126 1e-26
gi|1173335|sp|P16960|RYR1_PIG Ryanodine receptor 1 (Skeletal mus... 126 1e-26
gi|3845349|gb|AAC71651.1| RYNR_HUMAN [AA 4362- 5032]; SKELETAL M... 126 1e-26
gi|107631|pir||A35041 ryanodine receptor type 1, skeletal muscle... 126 1e-26
gi|1526615|emb|CAA69029.1| ryanodine receptor type 3 [Mustela vi... 125 1e-26
gi|7441641|pir||S74173 ryanodine receptor 3 - Mustela sp 125 1e-26
gi|38075725|ref|XP_130497.2| ryanodine receptor 3 [Mus musculus] 125 1e-26
gi|2136637|pir||I46646 ryanodine receptor, skeletal muscle - pig... 125 1e-26
gi|164646|gb|AAA31118.1| ryanodine receptor [Sus scrofa] 125 1e-26
gi|693803|gb|AAB32056.1| ryanodine receptor, RYR=ryanodine-sensi... 125 1e-26
gi|346611|pir||S27272 ryanodine receptor, brain - rabbit >gnl|BL... 125 1e-26
gi|37704386|ref|NP_001027.2| ryanodine receptor 3 [Homo sapiens] 125 1e-26
gi|18202506|sp|Q15413|RYR3_HUMAN Ryanodine receptor 3 (Brain-typ... 125 1e-26
gi|2696015|dbj|BAA23795.1| brain ryanodine receptor [Homo sapiens] 125 1e-26
gi|228961|prf||1814504A ryanodine receptor beta4 124 3e-26
gi|29501272|dbj|BAA04647.2| ryanodine receptor beta isoform [Ran... 124 4e-26
gi|1079343|pir||B54161 ryanodine-binding protein beta form - bul... 124 4e-26
gi|47218152|emb|CAG10072.1| unnamed protein product [Tetraodon n... 124 5e-26
gi|2119535|pir||I48741 ryanodine receptor type 1 - mouse (fragme... 122 1e-25
gi|833799|emb|CAA78855.1| ssryr_cds [Sus scrofa] 122 2e-25
gi|401055|sp|P30957|RYR2_RABIT Ryanodine receptor 2 (Cardiac mus... 122 2e-25
gi|1871612|emb|CAA69138.1| ryanodine receptor [Oryctolagus cunic... 122 2e-25
gi|28628791|gb|AAO49356.1| ryanodine receptor pRyR [Periplaneta ... 122 2e-25
gi|1841943|emb|CAA65105.1| ryanodine receptor 2 [Sus scrofa] 122 2e-25
gi|1245376|gb|AAA93465.1| cardiac ryanodine receptor 122 2e-25
gi|2119534|pir||I48742 ryanodine receptor type 2 - mouse (fragme... 121 3e-25
gi|17352469|ref|NP_476993.1| CG10844-PC [Drosophila melanogaster... 121 3e-25
gi|17352465|ref|NP_476991.1| CG10844-PA [Drosophila melanogaster... 121 3e-25
gi|50740993|ref|XP_419553.1| PREDICTED: similar to Ryanodine rec... 121 3e-25
gi|2160478|dbj|BAA04212.1| ryanodine receptor homologue [Drosoph... 121 3e-25
gi|48094968|ref|XP_392217.1| similar to ENSANGP00000023306 [Apis... 121 3e-25
gi|2160477|dbj|BAA41471.1| ryanodine receptor homologue [Drosoph... 121 3e-25
gi|1871614|emb|CAA69139.1| ryanodine receptor [Oryctolagus cunic... 121 3e-25
gi|13569850|ref|NP_076357.1| ryanodine receptor 2, cardiac; calc... 121 3e-25
gi|4506757|ref|NP_001026.1| ryanodine receptor 2 [Homo sapiens] ... 121 3e-25
gi|17352471|ref|NP_476994.1| CG10844-PD [Drosophila melanogaster... 121 3e-25
gi|17352467|ref|NP_476992.1| CG10844-PB [Drosophila melanogaster... 121 3e-25
gi|456984|gb|AAB29457.1| ryanodine receptor, calcium release cha... 121 3e-25
gi|630870|pir||S40450 ryanodine receptor/calcium release channel... 121 3e-25
gi|2160476|dbj|BAA41470.1| ryanodine receptor homologue [Drosoph... 121 3e-25
gi|4102119|gb|AAD01425.1| ryanodine receptor [Heliothis virescens] 120 4e-25
gi|227245|prf||1617118A ryanodine receptor 119 2e-24
gi|763545|gb|AAA64955.1| ryanodine receptor type 1 119 2e-24
gi|763549|gb|AAA64957.1| ryanodine receptor type 3 118 2e-24
gi|18656155|dbj|BAB84714.1| ryanodine receptor [Hemicentrotus pu... 118 2e-24
gi|31231666|ref|XP_318563.1| ENSANGP00000023306 [Anopheles gambi... 118 3e-24
gi|31231660|ref|XP_318562.1| ENSANGP00000022873 [Anopheles gambi... 118 3e-24
gi|31231655|ref|XP_318561.1| ENSANGP00000019607 [Anopheles gambi... 118 3e-24
gi|1841945|emb|CAA65104.1| ryanodine receptor 3 [Sus scrofa] 117 6e-24
gi|1212910|emb|CAA64562.1| ryanodine receptor type 1 [Gallus gal... 116 8e-24
gi|2970625|gb|AAC06013.1| ryanodine receptor [Homarus americanus] 116 8e-24
gi|34876277|ref|XP_341549.1| ryanodine receptor type II [Rattus ... 113 9e-23
gi|477885|pir||B49131 ryanodine receptor Dry / intracellular Ca(... 111 3e-22
gi|47227185|emb|CAG00547.1| unnamed protein product [Tetraodon n... 110 5e-22
gi|405719|emb|CAA52326.1| ryanodine receptor type 3 [Homo sapiens] 110 5e-22
gi|1055287|gb|AAC53099.1| inositol 1,4,5-trisphosphate receptor 110 6e-22
gi|7879|emb|CAA79221.1| ryanodine receptor [Drosophila melanogas... 105 2e-20
gi|763547|gb|AAA64956.1| ryanodine receptor type 2 96 1e-17
gi|34856658|ref|XP_342492.1| ryanodine receptor 3 [Rattus norveg... 95 3e-17
gi|46560604|gb|AAT00630.1| inositol 1,4,5-triphosphate receptor-... 94 6e-17
gi|47196873|emb|CAF89254.1| unnamed protein product [Tetraodon n... 85 4e-14
gi|13879583|gb|AAH06773.1| Itpr3 protein [Mus musculus] 84 5e-14
gi|5823031|gb|AAD53013.1| ryanodine receptor [Expression vector ... 83 1e-13
gi|1363229|pir||S56107 ryanodine receptor 3 - mouse (fragment) >... 81 4e-13
gi|1030708|dbj|BAA07391.1| skeletal muscle ryanodine receptor [M... 80 7e-13
gi|1583174|prf||2120276A ryanodine receptor:ISOTYPE=1 80 9e-13
gi|1030710|dbj|BAA07392.1| cardiac ryanodine receptor [Mus muscu... 79 1e-12
gi|4262086|gb|AAD14386.1| inositol 1,4,5 trisphosphate receptor ... 79 2e-12
gi|9187975|emb|CAB97127.1| inositol 1,4,5-trisphosphate receptor... 78 4e-12
gi|1363227|pir||S56105 ryanodine receptor 1 - mouse (fragment) 77 6e-12
gi|2136552|pir||S68273 inositol 1,4,5-trisphosphate receptor s1 ... 77 6e-12
gi|4868341|gb|AAD31270.1| ryanodine receptor type 1 [Rattus norv... 76 1e-11
gi|38086191|ref|XP_355874.1| similar to ryanodine receptor [Mus ... 75 3e-11
gi|4868345|gb|AAD31272.1| ryanodine receptor type 3 [Rattus norv... 75 4e-11
gi|2136136|pir||S66631 ryanodine receptor 3 - human (fragment) >... 74 8e-11
gi|47224547|emb|CAG03531.1| unnamed protein product [Tetraodon n... 73 1e-10
gi|47230257|emb|CAG10671.1| unnamed protein product [Tetraodon n... 71 5e-10
gi|29165716|gb|AAH43140.1| Similar to ryanodine receptor 2, card... 68 3e-09
gi|1054963|gb|AAB51330.1| inositol 1,4,5-trisphosphate receptor 68 4e-09
gi|47209126|emb|CAF94369.1| unnamed protein product [Tetraodon n... 65 3e-08
gi|15824345|gb|AAL09307.1| skeletal muscle ryanodine receptor [C... 62 2e-07
gi|1769447|emb|CAA89860.1| skeletal muscle ryanodine receptor [S... 59 2e-06
gi|34855651|ref|XP_341822.1| similar to Ryanodine receptor 2 (Ca... 59 2e-06
gi|7656700|gb|AAF66076.1| Homo sapiens ryanodine receptor 1 (ske... 56 1e-05
gi|34855647|ref|XP_341820.1| similar to ryanodine receptor [Ratt... 55 3e-05
gi|47224548|emb|CAG03532.1| unnamed protein product [Tetraodon n... 55 3e-05
gi|47224546|emb|CAG03530.1| unnamed protein product [Tetraodon n... 54 5e-05
gi|1930136|gb|AAB70013.1| ryanodine receptor type II [Rattus nor... 52 3e-04
gi|47230258|emb|CAG10672.1| unnamed protein product [Tetraodon n... 50 0.001
gi|38075727|ref|XP_355386.1| similar to Ryanodine receptor 3 (Br... 49 0.002
gi|34857574|ref|XP_345418.1| similar to Ryanodine receptor 3 (Br... 49 0.002
gi|1935|emb|CAA48318.1| calcium release channel [Sus scrofa] 49 0.002
gi|2136606|pir||I47214 probable brain ryanodine receptor - pig (... 49 0.002
gi|4102115|gb|AAD01423.1| ryanodine receptor [Heliothis virescens] 48 0.004
gi|1022321|emb|CAA62975.1| ryanodine receptor [Homo sapiens] 48 0.005
gi|2136485|pir||I47213 cardiac muscle ryanodine receptor - pig (... 48 0.005
gi|34876273|ref|XP_225491.2| similar to cardiac Ca2+ release cha... 48 0.005
gi|13397939|emb|CAC34624.1| skeletal muscle ryanodine receptor [... 47 0.006
gi|562096|gb|AAA60467.1| skeletal muscle ryanodine receptor 47 0.011
gi|2582751|emb|CAA05503.1| ryanodine receptor 3 [Homo sapiens] 46 0.014
gi|111837|pir||B38641 inositol 1,4,5-triphosphate receptor, shor... 46 0.018
gi|2305244|gb|AAB65756.1| ryanodine receptor 1 [Rattus norvegicus] 45 0.031
gi|2305248|gb|AAB65758.1| ryanodine receptor 3 [Rattus norvegicus] 44 0.053
gi|5731972|gb|AAD48899.1| ryanodine receptor type 1 [Rattus norv... 44 0.053
gi|47209654|emb|CAF92459.1| unnamed protein product [Tetraodon n... 44 0.090
gi|2305246|gb|AAB65757.1| ryanodine receptor 2 [Rattus norvegicus] 44 0.090
gi|543822|sp|Q01613|APX_XENLA Apical protein (APX) >gnl|BL_ORD_I... 42 0.26
gi|47179465|emb|CAG14775.1| unnamed protein product [Tetraodon n... 33 0.28
gi|23480467|gb|EAA17018.1| rhoptry protein [Plasmodium yoelii yo... 41 0.45
gi|23491382|gb|EAA22927.1| hypothetical protein [Plasmodium yoel... 41 0.59
gi|19113921|ref|NP_593009.1| hypothetical coiled-coil protein [S... 40 1.0
gi|15238181|ref|NP_198994.1| COP1-interactive protein 1 / CIP1 [... 40 1.3
gi|39583895|emb|CAE63985.1| Hypothetical protein CBG08577 [Caeno... 40 1.3
gi|50302181|ref|XP_451024.1| unnamed protein product [Kluyveromy... 40 1.3
gi|5852122|emb|CAB55367.1| putative tubulin-tyrosine ligase [Lei... 39 1.7
gi|37683071|gb|AAQ98613.1| ryanodine receptor 1 [Equus caballus] 39 1.7
gi|4868343|gb|AAD31271.1| ryanodine receptor type 2 [Rattus norv... 39 1.7
gi|2119536|pir||I48743 ryanodine receptor type 3 - mouse (fragme... 39 2.2
gi|50539838|ref|NP_001002385.1| zgc:92052 [Danio rerio] >gnl|BL_... 39 2.9
gi|46227114|gb|EAK88064.1| protein with forkhead associated (FHA... 38 3.8
gi|112957|sp|P05095|AACT_DICDI Alpha-actinin, non-muscular (F-ac... 38 5.0
gi|28573169|ref|NP_788597.1| CG32940-PA [Drosophila melanogaster... 38 5.0
gi|28573173|ref|NP_788600.1| CG32940-PD [Drosophila melanogaster... 38 5.0
gi|21686697|ref|NP_663197.1| hypothetical protein [Phthorimaea o... 38 5.0
gi|108755|pir||A38318 inositol 1,4,5-triphosphate receptor - bov... 37 6.5
gi|49067821|ref|XP_398200.1| hypothetical protein UM00585.1 [Ust... 37 6.5
gi|46229305|gb|EAK90154.1| Low complexity hypothetical protein [... 37 6.5
gi|32398946|emb|CAD98411.1| similarity to rod-like tail of sever... 37 6.5
gi|50762120|ref|XP_424943.1| PREDICTED: similar to coiled-coil d... 37 8.5
gi|50747376|ref|XP_420851.1| PREDICTED: similar to RNA polymeras... 37 8.5
gi|111836|pir||A38641 inositol 1,4,5-triphosphate receptor, long... 37 8.5
gi|26189984|emb|CAD34591.1| heme oxygenase [Ceratodon purpureus] 37 8.5
gi|21243825|ref|NP_643407.1| PilL protein [Xanthomonas axonopodi... 37 8.5
gi|23123961|ref|ZP_00105984.1| COG0642: Signal transduction hist... 37 8.5
gi|25012112|ref|NP_736507.1| unknown [Streptococcus agalactiae N... 37 8.5
>gi|17541128|ref|NP_501252.1| inositol 1 4 5-Triphosphate Receptor,
DEfecation Cycle abnormal DEC-4, Let-23 Fertility
Effector/regulator LFE-1 (325.9 kD) (itr-1)
[Caenorhabditis elegans]
gi|5262805|emb|CAB45860.1| inositol 1,4,5-trisphosphate receptor
[Caenorhabditis elegans]
gi|6175844|gb|AAF05302.1| inositol 1,4,5-trisphosphate receptor
[Caenorhabditis elegans]
gi|14574168|gb|AAK68366.1| Inositol triphosphate receptor protein 1,
isoform f [Caenorhabditis elegans]
Length = 2846
Score = 5506 bits (14283), Expect = 0.0
Identities = 2757/2846 (96%), Positives = 2757/2846 (96%)
Frame = +1
Query: 1 MDYDYRRRVLERNIGMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLS 180
MDYDYRRRVLERNIGMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLS
Sbjct: 1 MDYDYRRRVLERNIGMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLS 60
Query: 181 TLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDD 360
TLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDD
Sbjct: 61 TLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDD 120
Query: 361 DLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNA 540
DLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNA
Sbjct: 121 DLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNA 180
Query: 541 MKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSF 720
MKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSF
Sbjct: 181 MKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSF 240
Query: 721 NLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPK 900
NLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPK
Sbjct: 241 NLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPK 300
Query: 901 QNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYL 1080
QNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYL
Sbjct: 301 QNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYL 360
Query: 1081 SAEPSQVQVKPAMNGRRASLIYSKTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPT 1260
SAEPSQVQVKPAMNGRRASLIYSKTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPT
Sbjct: 361 SAEPSQVQVKPAMNGRRASLIYSKTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPT 420
Query: 1261 KSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSK 1440
KSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSK
Sbjct: 421 KSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSK 480
Query: 1441 NEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKES 1620
NEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKES
Sbjct: 481 NEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKES 540
Query: 1621 INSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLP 1800
INSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLP
Sbjct: 541 INSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLP 600
Query: 1801 RQGTTXXXXXXXXXXXXXDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQ 1980
RQGTT DSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQ
Sbjct: 601 RQGTTELGPLLSSPSELSDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQ 660
Query: 1981 IGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEA 2160
IGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEA
Sbjct: 661 IGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEA 720
Query: 2161 NKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSNSDDAEHLD 2340
NKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSNSDDAEHLD
Sbjct: 721 NKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSNSDDAEHLD 780
Query: 2341 YYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTR 2520
YYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTR
Sbjct: 781 YYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTR 840
Query: 2521 LMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLA 2700
LMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLA
Sbjct: 841 LMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLA 900
Query: 2701 TVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINE 2880
TVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINE
Sbjct: 901 TVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINE 960
Query: 2881 GPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKT 3060
GPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKT
Sbjct: 961 GPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKT 1020
Query: 3061 KLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASELYDAIYRS 3240
KLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASELYDAIYRS
Sbjct: 1021 KLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASELYDAIYRS 1080
Query: 3241 SGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVS 3420
SGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVS
Sbjct: 1081 SGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVS 1140
Query: 3421 NNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSP 3600
NNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSP
Sbjct: 1141 NNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSP 1200
Query: 3601 RAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYP 3780
RAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYP
Sbjct: 1201 RAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYP 1260
Query: 3781 LIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITL 3960
LIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITL
Sbjct: 1261 LIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITL 1320
Query: 3961 SHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVP 4140
SHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVP
Sbjct: 1321 SHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVP 1380
Query: 4141 EELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDN 4320
EELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDN
Sbjct: 1381 EELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDN 1440
Query: 4321 ASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDH 4500
ASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDH
Sbjct: 1441 ASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDH 1500
Query: 4501 IVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEK 4680
IVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEK
Sbjct: 1501 IVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEK 1560
Query: 4681 LTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGK 4860
LTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGK
Sbjct: 1561 LTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGK 1620
Query: 4861 LRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWI 5040
LRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWI
Sbjct: 1621 LRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWI 1680
Query: 5041 GIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLV 5220
GIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLV
Sbjct: 1681 GIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLV 1740
Query: 5221 EVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTK 5400
EVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTK
Sbjct: 1741 EVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTK 1800
Query: 5401 XXXXXXXXXXXXXXXXRYFGHHNNHHPPLDRQQSXXXXXXXXXXXXXXXTWSQERDLYAI 5580
RYFGHHNNHHPPLDRQQS TWSQERDLYAI
Sbjct: 1801 QQLTHQGQQLRQLLLQRYFGHHNNHHPPLDRQQSKIGEVIEAVKEKKEETWSQERDLYAI 1860
Query: 5581 QCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEP 5760
QCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEP
Sbjct: 1861 QCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEP 1920
Query: 5761 FFKAILTRIQTAQNRLKSDMMSCSDSKPKVSLSATVSRRSSTVLTPLIDAGDTGFNGALF 5940
FFKAILTRIQTAQNRLKSDMMSCSDSKPKVSLSATVSRRSSTVLTPLIDAGDTGFNGALF
Sbjct: 1921 FFKAILTRIQTAQNRLKSDMMSCSDSKPKVSLSATVSRRSSTVLTPLIDAGDTGFNGALF 1980
Query: 5941 EVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPEVALVEPILRVLQLLCE 6120
EVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPEVALVEPILRVLQLLCE
Sbjct: 1981 EVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPEVALVEPILRVLQLLCE 2040
Query: 6121 NHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFGEIGEHNFSLITQTLAT 6300
NHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFGEIGEHNFSLITQTLAT
Sbjct: 2041 NHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFGEIGEHNFSLITQTLAT 2100
Query: 6301 LTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIM 6480
LTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIM
Sbjct: 2101 LTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIM 2160
Query: 6481 ESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLK 6660
ESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLK
Sbjct: 2161 ESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLK 2220
Query: 6661 KKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNIYI 6840
KKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNIYI
Sbjct: 2221 KKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNIYI 2280
Query: 6841 LAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPINDI 7020
LAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPINDI
Sbjct: 2281 LAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPINDI 2340
Query: 7021 CSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPL 7200
CSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPL
Sbjct: 2341 CSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPL 2400
Query: 7201 WTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFAVFSSFLLAHYLRHDKIYLHK 7380
WTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFAVFSSFLLAHYLRHDKIYLHK
Sbjct: 2401 WTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFAVFSSFLLAHYLRHDKIYLHK 2460
Query: 7381 TXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRN 7560
T IGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRN
Sbjct: 2461 TSLLILASLCFLLLSSIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRN 2520
Query: 7561 LHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALIL 7740
LHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALIL
Sbjct: 2521 LHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALIL 2580
Query: 7741 LYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSETCPSEGCPGLQPSXXXXXXXXX 7920
LYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSETCPSEGCPGLQPS
Sbjct: 2581 LYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSETCPSEGCPGLQPSEKDDNDDEK 2640
Query: 7921 XXXSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTXXXXXXXXXXX 8100
SCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMT
Sbjct: 2641 KVKSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTFFVVLIVIVLN 2700
Query: 8101 XXXXXXXDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLY 8280
DTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLY
Sbjct: 2701 LIFGVIIDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLY 2760
Query: 8281 YIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLL 8460
YIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLL
Sbjct: 2761 YIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLL 2820
Query: 8461 QMMTLMREIISQNEESRAFMEQFQPR 8538
QMMTLMREIISQNEESRAFMEQFQPR
Sbjct: 2821 QMMTLMREIISQNEESRAFMEQFQPR 2846
>gi|25153695|ref|NP_501250.2| inositol 1 4 5-Triphosphate Receptor,
DEfecation Cycle abnormal DEC-4, Let-23 Fertility
Effector/regulator LFE-1 (330.8 kD) (itr-1)
[Caenorhabditis elegans]
gi|5262807|emb|CAB45861.1| inositol 1,4,5-trisphosphate receptor
[Caenorhabditis elegans]
Length = 2892
Score = 5479 bits (14213), Expect = 0.0
Identities = 2745/2845 (96%), Positives = 2747/2845 (96%)
Frame = +1
Query: 4 DYDYRRRVLERNIGMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLST 183
D+D + R MALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLST
Sbjct: 48 DFDDFEEQIMRKSSMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLST 107
Query: 184 LGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDD 363
LGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDD
Sbjct: 108 LGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDD 167
Query: 364 LMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAM 543
LMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAM
Sbjct: 168 LMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAM 227
Query: 544 KVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFN 723
KVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFN
Sbjct: 228 KVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFN 287
Query: 724 LLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQ 903
LLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQ
Sbjct: 288 LLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQ 347
Query: 904 NPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLS 1083
NPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLS
Sbjct: 348 NPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLS 407
Query: 1084 AEPSQVQVKPAMNGRRASLIYSKTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTK 1263
AEPSQVQVKPAMNGRRASLIYSKTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTK
Sbjct: 408 AEPSQVQVKPAMNGRRASLIYSKTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTK 467
Query: 1264 SEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKN 1443
SEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKN
Sbjct: 468 SEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKN 527
Query: 1444 EKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKESI 1623
EKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKESI
Sbjct: 528 EKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKESI 587
Query: 1624 NSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPR 1803
NSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPR
Sbjct: 588 NSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPR 647
Query: 1804 QGTTXXXXXXXXXXXXXDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQI 1983
QGTT DSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQI
Sbjct: 648 QGTTELGPLLSSPSELSDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQI 707
Query: 1984 GFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEAN 2163
GFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEAN
Sbjct: 708 GFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEAN 767
Query: 2164 KKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSNSDDAEHLDY 2343
KKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSNSDDAEHLDY
Sbjct: 768 KKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSNSDDAEHLDY 827
Query: 2344 YRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRL 2523
YRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRL
Sbjct: 828 YRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRL 887
Query: 2524 MLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLAT 2703
MLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLAT
Sbjct: 888 MLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLAT 947
Query: 2704 VETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINEG 2883
VETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINEG
Sbjct: 948 VETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINEG 1007
Query: 2884 PATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKTK 3063
PATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKTK
Sbjct: 1008 PATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKTK 1067
Query: 3064 LIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASELYDAIYRSS 3243
LIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASELYDAIYRSS
Sbjct: 1068 LIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASELYDAIYRSS 1127
Query: 3244 GHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSN 3423
GHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSN
Sbjct: 1128 GHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSN 1187
Query: 3424 NDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPR 3603
NDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPR
Sbjct: 1188 NDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPR 1247
Query: 3604 AFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPL 3783
AFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPL
Sbjct: 1248 AFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPL 1307
Query: 3784 IRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLS 3963
IRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLS
Sbjct: 1308 IRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLS 1367
Query: 3964 HEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPE 4143
HEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPE
Sbjct: 1368 HEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPE 1427
Query: 4144 ELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNA 4323
ELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNA
Sbjct: 1428 ELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNA 1487
Query: 4324 SFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHI 4503
SFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHI
Sbjct: 1488 SFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHI 1547
Query: 4504 VRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEKL 4683
VRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEKL
Sbjct: 1548 VRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEKL 1607
Query: 4684 TGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGKL 4863
TGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGKL
Sbjct: 1608 TGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGKL 1667
Query: 4864 RGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWIG 5043
RGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWIG
Sbjct: 1668 RGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWIG 1727
Query: 5044 IGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVE 5223
IGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVE
Sbjct: 1728 IGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVE 1787
Query: 5224 VLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKX 5403
VLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTK
Sbjct: 1788 VLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKQ 1847
Query: 5404 XXXXXXXXXXXXXXXRYFGHHNNHHPPLDRQQSXXXXXXXXXXXXXXXTWSQERDLYAIQ 5583
RYFGHHNNHHPPLDRQQS TWSQERDLYAIQ
Sbjct: 1848 QLTHQGQQLRQLLLQRYFGHHNNHHPPLDRQQSKIGEVIEAVKEKKEETWSQERDLYAIQ 1907
Query: 5584 CKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEPF 5763
CKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEPF
Sbjct: 1908 CKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEPF 1967
Query: 5764 FKAILTRIQTAQNRLKSDMMSCSDSKPKVSLSATVSRRSSTVLTPLIDAGDTGFNGALFE 5943
FKAILTRIQTAQNRLKSDMMSCSDSKPKVSLSATVSRRSSTVLTPLIDAGDTGFNGALFE
Sbjct: 1968 FKAILTRIQTAQNRLKSDMMSCSDSKPKVSLSATVSRRSSTVLTPLIDAGDTGFNGALFE 2027
Query: 5944 VPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPEVALVEPILRVLQLLCEN 6123
VPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPEVALVEPILRVLQLLCEN
Sbjct: 2028 VPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPEVALVEPILRVLQLLCEN 2087
Query: 6124 HNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFGEIGEHNFSLITQTLATL 6303
HNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFGEIGEHNFSLITQTLATL
Sbjct: 2088 HNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFGEIGEHNFSLITQTLATL 2147
Query: 6304 TEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIME 6483
TEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIME
Sbjct: 2148 TEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIME 2207
Query: 6484 SRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLKK 6663
SRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLKK
Sbjct: 2208 SRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLKK 2267
Query: 6664 KSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNIYIL 6843
KSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNIYIL
Sbjct: 2268 KSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNIYIL 2327
Query: 6844 AHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPINDIC 7023
AHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPINDIC
Sbjct: 2328 AHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPINDIC 2387
Query: 7024 SYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPLW 7203
SYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPLW
Sbjct: 2388 SYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPLW 2447
Query: 7204 TRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFAVFSSFLLAHYLRHDKIYLHKT 7383
TRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFAVFSSFLLAHYLRHDKIYLHKT
Sbjct: 2448 TRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFAVFSSFLLAHYLRHDKIYLHKT 2507
Query: 7384 XXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRNL 7563
IGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRNL
Sbjct: 2508 SLLILASLCFLLLSSIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRNL 2567
Query: 7564 HYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALILL 7743
HYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALILL
Sbjct: 2568 HYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALILL 2627
Query: 7744 YFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSETCPSEGCPGLQPSXXXXXXXXXX 7923
YFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSETCPSEGCPGLQPS
Sbjct: 2628 YFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSETCPSEGCPGLQPSEKDDNDDEKK 2687
Query: 7924 XXSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTXXXXXXXXXXXX 8103
SCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMT
Sbjct: 2688 VKSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTFFVVLIVIVLNL 2747
Query: 8104 XXXXXXDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLYY 8283
DTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLYY
Sbjct: 2748 IFGVIIDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLYY 2807
Query: 8284 IVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLLQ 8463
IVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLLQ
Sbjct: 2808 IVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLLQ 2867
Query: 8464 MMTLMREIISQNEESRAFMEQFQPR 8538
MMTLMREIISQNEESRAFMEQFQPR
Sbjct: 2868 MMTLMREIISQNEESRAFMEQFQPR 2892
>gi|25153698|ref|NP_501251.2| inositol 1 4 5-Triphosphate Receptor,
DEfecation Cycle abnormal DEC-4, Let-23 Fertility
Effector/regulator LFE-1 (324.6 kD) (itr-1)
[Caenorhabditis elegans]
gi|5262809|emb|CAB45862.1| inositol 1,4,5-trisphosphate receptor
[Caenorhabditis elegans]
Length = 2836
Score = 5476 bits (14206), Expect = 0.0
Identities = 2743/2835 (96%), Positives = 2743/2835 (96%)
Frame = +1
Query: 34 RNIGMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIV 213
R MALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIV
Sbjct: 2 RKSSMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIV 61
Query: 214 ELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAAD 393
ELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAAD
Sbjct: 62 ELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAAD 121
Query: 394 KEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNE 573
KEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNE
Sbjct: 122 KEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNE 181
Query: 574 GSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEV 753
GSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEV
Sbjct: 182 GSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEV 241
Query: 754 NCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLR 933
NCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLR
Sbjct: 242 NCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLR 301
Query: 934 MTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKP 1113
MTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKP
Sbjct: 302 MTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKP 361
Query: 1114 AMNGRRASLIYSKTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANL 1293
AMNGRRASLIYSKTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANL
Sbjct: 362 AMNGRRASLIYSKTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANL 421
Query: 1294 LFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWVKVICE 1473
LFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWVKVICE
Sbjct: 422 LFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWVKVICE 481
Query: 1474 KNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDC 1653
KNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDC
Sbjct: 482 KNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDC 541
Query: 1654 ILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXX 1833
ILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTT
Sbjct: 542 ILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTELGPLL 601
Query: 1834 XXXXXXXDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTM 2013
DSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTM
Sbjct: 602 SSPSELSDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTM 661
Query: 2014 TAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTS 2193
TAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTS
Sbjct: 662 TAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTS 721
Query: 2194 VLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSNSDDAEHLDYYRHQLDLLSQ 2373
VLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSNSDDAEHLDYYRHQLDLLSQ
Sbjct: 722 VLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSNSDDAEHLDYYRHQLDLLSQ 781
Query: 2374 MCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLHLHVVRGS 2553
MCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLHLHVVRGS
Sbjct: 782 MCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLHLHVVRGS 841
Query: 2554 PMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATVETYLMGLRN 2733
PMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATVETYLMGLRN
Sbjct: 842 PMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATVETYLMGLRN 901
Query: 2734 QSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINEGPATEQVPSHR 2913
QSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINEGPATEQVPSHR
Sbjct: 902 QSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINEGPATEQVPSHR 961
Query: 2914 AMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKTKLIVAEILQFV 3093
AMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKTKLIVAEILQFV
Sbjct: 962 AMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKTKLIVAEILQFV 1021
Query: 3094 MDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASELYDAIYRSSGHELHLDGRD 3273
MDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASELYDAIYRSSGHELHLDGRD
Sbjct: 1022 MDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASELYDAIYRSSGHELHLDGRD 1081
Query: 3274 GQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQID 3453
GQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQID
Sbjct: 1082 GQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQID 1141
Query: 3454 RDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEA 3633
RDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEA
Sbjct: 1142 RDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEA 1201
Query: 3634 LMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTG 3813
LMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTG
Sbjct: 1202 LMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTG 1261
Query: 3814 MCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKT 3993
MCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKT
Sbjct: 1262 MCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKT 1321
Query: 3994 NKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLI 4173
NKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLI
Sbjct: 1322 NKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLI 1381
Query: 4174 EHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMK 4353
EHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMK
Sbjct: 1382 EHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMK 1441
Query: 4354 DEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCL 4533
DEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCL
Sbjct: 1442 DEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCL 1501
Query: 4534 VEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEKLTGAETATLEH 4713
VEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEKLTGAETATLEH
Sbjct: 1502 VEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEKLTGAETATLEH 1561
Query: 4714 YICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGKLRGSKSSRNWY 4893
YICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGKLRGSKSSRNWY
Sbjct: 1562 YICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGKLRGSKSSRNWY 1621
Query: 4894 RVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNT 5073
RVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNT
Sbjct: 1622 RVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNT 1681
Query: 5074 LNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFP 5253
LNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFP
Sbjct: 1682 LNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFP 1741
Query: 5254 EGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKXXXXXXXXXXX 5433
EGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTK
Sbjct: 1742 EGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKQQLTHQGQQLR 1801
Query: 5434 XXXXXRYFGHHNNHHPPLDRQQSXXXXXXXXXXXXXXXTWSQERDLYAIQCKLNDAGASD 5613
RYFGHHNNHHPPLDRQQS TWSQERDLYAIQCKLNDAGASD
Sbjct: 1802 QLLLQRYFGHHNNHHPPLDRQQSKIGEVIEAVKEKKEETWSQERDLYAIQCKLNDAGASD 1861
Query: 5614 LVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEPFFKAILTRIQT 5793
LVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEPFFKAILTRIQT
Sbjct: 1862 LVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEPFFKAILTRIQT 1921
Query: 5794 AQNRLKSDMMSCSDSKPKVSLSATVSRRSSTVLTPLIDAGDTGFNGALFEVPQQVRHPSI 5973
AQNRLKSDMMSCSDSKPKVSLSATVSRRSSTVLTPLIDAGDTGFNGALFEVPQQVRHPSI
Sbjct: 1922 AQNRLKSDMMSCSDSKPKVSLSATVSRRSSTVLTPLIDAGDTGFNGALFEVPQQVRHPSI 1981
Query: 5974 SEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPEVALVEPILRVLQLLCENHNSLLQNFLR 6153
SEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPEVALVEPILRVLQLLCENHNSLLQNFLR
Sbjct: 1982 SEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPEVALVEPILRVLQLLCENHNSLLQNFLR 2041
Query: 6154 KQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFGEIGEHNFSLITQTLATLTEFCQGPCHE 6333
KQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFGEIGEHNFSLITQTLATLTEFCQGPCHE
Sbjct: 2042 KQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFGEIGEHNFSLITQTLATLTEFCQGPCHE 2101
Query: 6334 NQNTMAMQENGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIMESRHDGENANR 6513
NQNTMAMQENGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIMESRHDGENANR
Sbjct: 2102 NQNTMAMQENGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIMESRHDGENANR 2161
Query: 6514 VLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLKKKSGPQITVNT 6693
VLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLKKKSGPQITVNT
Sbjct: 2162 VLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLKKKSGPQITVNT 2221
Query: 6694 VTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNIYILAHQLAIHDGE 6873
VTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNIYILAHQLAIHDGE
Sbjct: 2222 VTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNIYILAHQLAIHDGE 2281
Query: 6874 LEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPINDICSYLTKDTKDY 7053
LEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPINDICSYLTKDTKDY
Sbjct: 2282 LEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPINDICSYLTKDTKDY 2341
Query: 7054 VYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPLWTRLSFHFAFI 7233
VYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPLWTRLSFHFAFI
Sbjct: 2342 VYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPLWTRLSFHFAFI 2401
Query: 7234 VNALVARYYPLPEHSNSSISLGNLYSWFAVFSSFLLAHYLRHDKIYLHKTXXXXXXXXXX 7413
VNALVARYYPLPEHSNSSISLGNLYSWFAVFSSFLLAHYLRHDKIYLHKT
Sbjct: 2402 VNALVARYYPLPEHSNSSISLGNLYSWFAVFSSFLLAHYLRHDKIYLHKTSLLILASLCF 2461
Query: 7414 XXXXXIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRNLHYLLVYLFIC 7593
IGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRNLHYLLVYLFIC
Sbjct: 2462 LLLSSIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRNLHYLLVYLFIC 2521
Query: 7594 ILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALILLYFFSILGFLY 7773
ILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALILLYFFSILGFLY
Sbjct: 2522 ILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALILLYFFSILGFLY 2581
Query: 7774 FRHDFYLEVDPVENDSSATISSGIPSETCPSEGCPGLQPSXXXXXXXXXXXXSCETLWMC 7953
FRHDFYLEVDPVENDSSATISSGIPSETCPSEGCPGLQPS SCETLWMC
Sbjct: 2582 FRHDFYLEVDPVENDSSATISSGIPSETCPSEGCPGLQPSEKDDNDDEKKVKSCETLWMC 2641
Query: 7954 ILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTXXXXXXXXXXXXXXXXXXDTFG 8133
ILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMT DTFG
Sbjct: 2642 ILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTFFVVLIVIVLNLIFGVIIDTFG 2701
Query: 8134 DLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLYYIVMLQIKDET 8313
DLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLYYIVMLQIKDET
Sbjct: 2702 DLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLYYIVMLQIKDET 2761
Query: 8314 EFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLLQMMTLMREIIS 8493
EFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLLQMMTLMREIIS
Sbjct: 2762 EFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLLQMMTLMREIIS 2821
Query: 8494 QNEESRAFMEQFQPR 8538
QNEESRAFMEQFQPR
Sbjct: 2822 QNEESRAFMEQFQPR 2836
>gi|14574164|gb|AAK68362.1| Inositol triphosphate receptor protein 1,
isoform a [Caenorhabditis elegans]
Length = 2903
Score = 5471 bits (14193), Expect = 0.0
Identities = 2745/2856 (96%), Positives = 2747/2856 (96%), Gaps = 11/2856 (0%)
Frame = +1
Query: 4 DYDYRRRVLERNIGMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLST 183
D+D + R MALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLST
Sbjct: 48 DFDDFEEQIMRKSSMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLST 107
Query: 184 LGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDD 363
LGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDD
Sbjct: 108 LGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDD 167
Query: 364 LMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAM 543
LMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAM
Sbjct: 168 LMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAM 227
Query: 544 KVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFN 723
KVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFN
Sbjct: 228 KVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFN 287
Query: 724 LLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQ 903
LLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQ
Sbjct: 288 LLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQ 347
Query: 904 NPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLS 1083
NPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLS
Sbjct: 348 NPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLS 407
Query: 1084 AEPSQVQVKPAMNGRRASLIYSKTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTK 1263
AEPSQVQVKPAMNGRRASLIYSKTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTK
Sbjct: 408 AEPSQVQVKPAMNGRRASLIYSKTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTK 467
Query: 1264 SEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKN 1443
SEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKN
Sbjct: 468 SEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKN 527
Query: 1444 EKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKESI 1623
EKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKESI
Sbjct: 528 EKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKESI 587
Query: 1624 NSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPR 1803
NSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPR
Sbjct: 588 NSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPR 647
Query: 1804 QGTTXXXXXXXXXXXXXDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQI 1983
QGTT DSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQI
Sbjct: 648 QGTTELGPLLSSPSELSDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQI 707
Query: 1984 GFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEAN 2163
GFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEAN
Sbjct: 708 GFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEAN 767
Query: 2164 KKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSNSDDAEHLDY 2343
KKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSNSDDAEHLDY
Sbjct: 768 KKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSNSDDAEHLDY 827
Query: 2344 YRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRL 2523
YRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRL
Sbjct: 828 YRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRL 887
Query: 2524 MLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLAT 2703
MLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLAT
Sbjct: 888 MLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLAT 947
Query: 2704 VETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINEG 2883
VETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINEG
Sbjct: 948 VETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINEG 1007
Query: 2884 PATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKTK 3063
PATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKTK
Sbjct: 1008 PATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKTK 1067
Query: 3064 LIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASELYDAIYRSS 3243
LIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASELYDAIYRSS
Sbjct: 1068 LIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASELYDAIYRSS 1127
Query: 3244 GHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSN 3423
GHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSN
Sbjct: 1128 GHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSN 1187
Query: 3424 NDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPR 3603
NDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPR
Sbjct: 1188 NDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPR 1247
Query: 3604 AFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPL 3783
AFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPL
Sbjct: 1248 AFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPL 1307
Query: 3784 IRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLS 3963
IRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLS
Sbjct: 1308 IRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLS 1367
Query: 3964 HEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPE 4143
HEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPE
Sbjct: 1368 HEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPE 1427
Query: 4144 ELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNA 4323
ELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNA
Sbjct: 1428 ELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNA 1487
Query: 4324 SFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHI 4503
SFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHI
Sbjct: 1488 SFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHI 1547
Query: 4504 VRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEKL 4683
VRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEKL
Sbjct: 1548 VRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEKL 1607
Query: 4684 TGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGKL 4863
TGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGKL
Sbjct: 1608 TGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGKL 1667
Query: 4864 RGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWIG 5043
RGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWIG
Sbjct: 1668 RGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWIG 1727
Query: 5044 IGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVE 5223
IGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVE
Sbjct: 1728 IGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVE 1787
Query: 5224 VLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKX 5403
VLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTK
Sbjct: 1788 VLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKQ 1847
Query: 5404 XXXXXXXXXXXXX-----------XXRYFGHHNNHHPPLDRQQSXXXXXXXXXXXXXXXT 5550
RYFGHHNNHHPPLDRQQS T
Sbjct: 1848 QLTHQGHRVYNSSVEKGQQLRQLLLQRYFGHHNNHHPPLDRQQSKIGEVIEAVKEKKEET 1907
Query: 5551 WSQERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYM 5730
WSQERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYM
Sbjct: 1908 WSQERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYM 1967
Query: 5731 RMKQKDIHEPFFKAILTRIQTAQNRLKSDMMSCSDSKPKVSLSATVSRRSSTVLTPLIDA 5910
RMKQKDIHEPFFKAILTRIQTAQNRLKSDMMSCSDSKPKVSLSATVSRRSSTVLTPLIDA
Sbjct: 1968 RMKQKDIHEPFFKAILTRIQTAQNRLKSDMMSCSDSKPKVSLSATVSRRSSTVLTPLIDA 2027
Query: 5911 GDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPEVALVEP 6090
GDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPEVALVEP
Sbjct: 2028 GDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPEVALVEP 2087
Query: 6091 ILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFGEIGEHN 6270
ILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFGEIGEHN
Sbjct: 2088 ILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFGEIGEHN 2147
Query: 6271 FSLITQTLATLTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADDHMELALEIKS 6450
FSLITQTLATLTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADDHMELALEIKS
Sbjct: 2148 FSLITQTLATLTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADDHMELALEIKS 2207
Query: 6451 QASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRD 6630
QASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRD
Sbjct: 2208 QASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRD 2267
Query: 6631 LFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVD 6810
LFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVD
Sbjct: 2268 LFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVD 2327
Query: 6811 PREVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTL 6990
PREVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTL
Sbjct: 2328 PREVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTL 2387
Query: 6991 ERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKW 7170
ERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKW
Sbjct: 2388 ERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKW 2447
Query: 7171 LSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFAVFSSFLLAHY 7350
LSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFAVFSSFLLAHY
Sbjct: 2448 LSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFAVFSSFLLAHY 2507
Query: 7351 LRHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDR 7530
LRHDKIYLHKT IGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDR
Sbjct: 2508 LRHDKIYLHKTSLLILASLCFLLLSSIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDR 2567
Query: 7531 PIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSI 7710
PIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSI
Sbjct: 2568 PIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSI 2627
Query: 7711 VWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSETCPSEGCPGLQP 7890
VWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSETCPSEGCPGLQP
Sbjct: 2628 VWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSETCPSEGCPGLQP 2687
Query: 7891 SXXXXXXXXXXXXSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTX 8070
S SCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMT
Sbjct: 2688 SEKDDNDDEKKVKSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTF 2747
Query: 8071 XXXXXXXXXXXXXXXXXDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRE 8250
DTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRE
Sbjct: 2748 FVVLIVIVLNLIFGVIIDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRE 2807
Query: 8251 TEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQS 8430
TEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQS
Sbjct: 2808 TEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQS 2867
Query: 8431 EVKQMKDQLLQMMTLMREIISQNEESRAFMEQFQPR 8538
EVKQMKDQLLQMMTLMREIISQNEESRAFMEQFQPR
Sbjct: 2868 EVKQMKDQLLQMMTLMREIISQNEESRAFMEQFQPR 2903
>gi|14574166|gb|AAK68364.1| Inositol triphosphate receptor protein 1,
isoform d [Caenorhabditis elegans]
Length = 2847
Score = 5469 bits (14186), Expect = 0.0
Identities = 2743/2846 (96%), Positives = 2743/2846 (96%), Gaps = 11/2846 (0%)
Frame = +1
Query: 34 RNIGMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIV 213
R MALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIV
Sbjct: 2 RKSSMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIV 61
Query: 214 ELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAAD 393
ELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAAD
Sbjct: 62 ELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAAD 121
Query: 394 KEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNE 573
KEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNE
Sbjct: 122 KEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNE 181
Query: 574 GSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEV 753
GSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEV
Sbjct: 182 GSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEV 241
Query: 754 NCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLR 933
NCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLR
Sbjct: 242 NCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLR 301
Query: 934 MTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKP 1113
MTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKP
Sbjct: 302 MTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKP 361
Query: 1114 AMNGRRASLIYSKTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANL 1293
AMNGRRASLIYSKTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANL
Sbjct: 362 AMNGRRASLIYSKTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANL 421
Query: 1294 LFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWVKVICE 1473
LFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWVKVICE
Sbjct: 422 LFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWVKVICE 481
Query: 1474 KNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDC 1653
KNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDC
Sbjct: 482 KNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDC 541
Query: 1654 ILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXX 1833
ILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTT
Sbjct: 542 ILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTELGPLL 601
Query: 1834 XXXXXXXDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTM 2013
DSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTM
Sbjct: 602 SSPSELSDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTM 661
Query: 2014 TAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTS 2193
TAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTS
Sbjct: 662 TAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTS 721
Query: 2194 VLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSNSDDAEHLDYYRHQLDLLSQ 2373
VLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSNSDDAEHLDYYRHQLDLLSQ
Sbjct: 722 VLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSNSDDAEHLDYYRHQLDLLSQ 781
Query: 2374 MCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLHLHVVRGS 2553
MCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLHLHVVRGS
Sbjct: 782 MCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLHLHVVRGS 841
Query: 2554 PMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATVETYLMGLRN 2733
PMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATVETYLMGLRN
Sbjct: 842 PMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATVETYLMGLRN 901
Query: 2734 QSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINEGPATEQVPSHR 2913
QSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINEGPATEQVPSHR
Sbjct: 902 QSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINEGPATEQVPSHR 961
Query: 2914 AMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKTKLIVAEILQFV 3093
AMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKTKLIVAEILQFV
Sbjct: 962 AMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKTKLIVAEILQFV 1021
Query: 3094 MDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASELYDAIYRSSGHELHLDGRD 3273
MDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASELYDAIYRSSGHELHLDGRD
Sbjct: 1022 MDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASELYDAIYRSSGHELHLDGRD 1081
Query: 3274 GQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQID 3453
GQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQID
Sbjct: 1082 GQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQID 1141
Query: 3454 RDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEA 3633
RDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEA
Sbjct: 1142 RDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEA 1201
Query: 3634 LMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTG 3813
LMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTG
Sbjct: 1202 LMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTG 1261
Query: 3814 MCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKT 3993
MCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKT
Sbjct: 1262 MCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKT 1321
Query: 3994 NKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLI 4173
NKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLI
Sbjct: 1322 NKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLI 1381
Query: 4174 EHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMK 4353
EHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMK
Sbjct: 1382 EHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMK 1441
Query: 4354 DEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCL 4533
DEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCL
Sbjct: 1442 DEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCL 1501
Query: 4534 VEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEKLTGAETATLEH 4713
VEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEKLTGAETATLEH
Sbjct: 1502 VEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEKLTGAETATLEH 1561
Query: 4714 YICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGKLRGSKSSRNWY 4893
YICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGKLRGSKSSRNWY
Sbjct: 1562 YICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGKLRGSKSSRNWY 1621
Query: 4894 RVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNT 5073
RVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNT
Sbjct: 1622 RVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNT 1681
Query: 5074 LNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFP 5253
LNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFP
Sbjct: 1682 LNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFP 1741
Query: 5254 EGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKXXXXXXXXXXX 5433
EGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTK
Sbjct: 1742 EGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKQQLTHQGHRVY 1801
Query: 5434 XXX-----------XXRYFGHHNNHHPPLDRQQSXXXXXXXXXXXXXXXTWSQERDLYAI 5580
RYFGHHNNHHPPLDRQQS TWSQERDLYAI
Sbjct: 1802 NSSVEKGQQLRQLLLQRYFGHHNNHHPPLDRQQSKIGEVIEAVKEKKEETWSQERDLYAI 1861
Query: 5581 QCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEP 5760
QCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEP
Sbjct: 1862 QCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEP 1921
Query: 5761 FFKAILTRIQTAQNRLKSDMMSCSDSKPKVSLSATVSRRSSTVLTPLIDAGDTGFNGALF 5940
FFKAILTRIQTAQNRLKSDMMSCSDSKPKVSLSATVSRRSSTVLTPLIDAGDTGFNGALF
Sbjct: 1922 FFKAILTRIQTAQNRLKSDMMSCSDSKPKVSLSATVSRRSSTVLTPLIDAGDTGFNGALF 1981
Query: 5941 EVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPEVALVEPILRVLQLLCE 6120
EVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPEVALVEPILRVLQLLCE
Sbjct: 1982 EVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPEVALVEPILRVLQLLCE 2041
Query: 6121 NHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFGEIGEHNFSLITQTLAT 6300
NHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFGEIGEHNFSLITQTLAT
Sbjct: 2042 NHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFGEIGEHNFSLITQTLAT 2101
Query: 6301 LTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIM 6480
LTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIM
Sbjct: 2102 LTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIM 2161
Query: 6481 ESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLK 6660
ESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLK
Sbjct: 2162 ESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLK 2221
Query: 6661 KKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNIYI 6840
KKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNIYI
Sbjct: 2222 KKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNIYI 2281
Query: 6841 LAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPINDI 7020
LAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPINDI
Sbjct: 2282 LAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPINDI 2341
Query: 7021 CSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPL 7200
CSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPL
Sbjct: 2342 CSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPL 2401
Query: 7201 WTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFAVFSSFLLAHYLRHDKIYLHK 7380
WTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFAVFSSFLLAHYLRHDKIYLHK
Sbjct: 2402 WTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFAVFSSFLLAHYLRHDKIYLHK 2461
Query: 7381 TXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRN 7560
T IGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRN
Sbjct: 2462 TSLLILASLCFLLLSSIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRN 2521
Query: 7561 LHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALIL 7740
LHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALIL
Sbjct: 2522 LHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALIL 2581
Query: 7741 LYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSETCPSEGCPGLQPSXXXXXXXXX 7920
LYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSETCPSEGCPGLQPS
Sbjct: 2582 LYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSETCPSEGCPGLQPSEKDDNDDEK 2641
Query: 7921 XXXSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTXXXXXXXXXXX 8100
SCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMT
Sbjct: 2642 KVKSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTFFVVLIVIVLN 2701
Query: 8101 XXXXXXXDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLY 8280
DTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLY
Sbjct: 2702 LIFGVIIDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLY 2761
Query: 8281 YIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLL 8460
YIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLL
Sbjct: 2762 YIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLL 2821
Query: 8461 QMMTLMREIISQNEESRAFMEQFQPR 8538
QMMTLMREIISQNEESRAFMEQFQPR
Sbjct: 2822 QMMTLMREIISQNEESRAFMEQFQPR 2847
>gi|17541126|ref|NP_501253.1| inositol 1 4 5-Triphosphate Receptor,
DEfecation Cycle abnormal DEC-4, Let-23 Fertility
Effector/regulator LFE-1 (327.2 kD) (itr-1)
[Caenorhabditis elegans]
gi|5262811|emb|CAB45863.1| inositol 1,4,5-trisphosphate receptor
[Caenorhabditis elegans]
gi|14574167|gb|AAK68365.1| Inositol triphosphate receptor protein 1,
isoform e [Caenorhabditis elegans]
Length = 2857
Score = 5454 bits (14148), Expect = 0.0
Identities = 2741/2866 (95%), Positives = 2743/2866 (95%), Gaps = 20/2866 (0%)
Frame = +1
Query: 1 MDYDYRRRVLERNIGMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLS 180
MDYDYRRRVLERNIGMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLS
Sbjct: 1 MDYDYRRRVLERNIGMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLS 60
Query: 181 TLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDD 360
TLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDD
Sbjct: 61 TLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDD 120
Query: 361 DLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNA 540
DLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNA
Sbjct: 121 DLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNA 180
Query: 541 MKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSF 720
MKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSF
Sbjct: 181 MKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSF 240
Query: 721 NLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPK 900
NLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPK
Sbjct: 241 NLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPK 300
Query: 901 QNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYL 1080
QNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYL
Sbjct: 301 QNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYL 360
Query: 1081 SAEPSQVQVKPAMNGRRASL---------IYSKTNNPMAMYSDGPNGVTNESTDTTQQNI 1233
SAEPSQVQVKPAMNGR L + +TNNPMAMYSDGPNGVTNESTDTTQQNI
Sbjct: 361 SAEPSQVQVKPAMNGRPPLLSALSQKSRPMLERTNNPMAMYSDGPNGVTNESTDTTQQNI 420
Query: 1234 PSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATE 1413
PSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATE
Sbjct: 421 PSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATE 480
Query: 1414 KQNLHYSSKNEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIK 1593
KQNLHYSSKNEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIK
Sbjct: 481 KQNLHYSSKNEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIK 540
Query: 1594 IGQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVF 1773
IGQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVF
Sbjct: 541 IGQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVF 600
Query: 1774 LLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLA 1953
LLLKAPFLPRQGTT DSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLA
Sbjct: 601 LLLKAPFLPRQGTTELGPLLSSPSELSDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLA 660
Query: 1954 EKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLA 2133
EKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLA
Sbjct: 661 EKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLA 720
Query: 2134 DLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKS 2313
DLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKS
Sbjct: 721 DLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKS 780
Query: 2314 NSDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLP 2493
NSDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLP
Sbjct: 781 NSDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLP 840
Query: 2494 YDLRGSFTRLMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIG 2673
YDLRGSFTRLMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIG
Sbjct: 841 YDLRGSFTRLMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIG 900
Query: 2674 EGIAHKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLT 2853
EGIAHKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLT
Sbjct: 901 EGIAHKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLT 960
Query: 2854 QNLLAIINEGPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTK 3033
QNLLAIINEGPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTK
Sbjct: 961 QNLLAIINEGPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTK 1020
Query: 3034 EGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMAS 3213
EGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMAS
Sbjct: 1021 EGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMAS 1080
Query: 3214 ELYDAIYRSSGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLED 3393
ELYDAIYRSSGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLED
Sbjct: 1081 ELYDAIYRSSGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLED 1140
Query: 3394 LKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHD 3573
LKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHD
Sbjct: 1141 LKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHD 1200
Query: 3574 LLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELS 3753
LLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELS
Sbjct: 1201 LLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELS 1260
Query: 3754 DKAPLIAYPLIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHD 3933
DKAPLIAYPLIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHD
Sbjct: 1261 DKAPLIAYPLIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHD 1320
Query: 3934 HDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRN 4113
HDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRN
Sbjct: 1321 HDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRN 1380
Query: 4114 NRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASD 4293
NRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASD
Sbjct: 1381 NRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASD 1440
Query: 4294 EVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELK 4473
EVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELK
Sbjct: 1441 EVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELK 1500
Query: 4474 CASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLE 4653
CASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLE
Sbjct: 1501 CASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLE 1560
Query: 4654 DIRSLRVEKLTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLL 4833
DIRSLRVEKLTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLL
Sbjct: 1561 DIRSLRVEKLTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLL 1620
Query: 4834 ELTYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQ 5013
ELTYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQ
Sbjct: 1621 ELTYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQ 1680
Query: 5014 QAASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPL 5193
QAASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPL
Sbjct: 1681 QAASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPL 1740
Query: 5194 HAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQT 5373
HAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQT
Sbjct: 1741 HAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQT 1800
Query: 5374 LCKMCDCTKXXXXXXXXXXXXXX-----------XXRYFGHHNNHHPPLDRQQSXXXXXX 5520
LCKMCDCTK RYFGHHNNHHPPLDRQQS
Sbjct: 1801 LCKMCDCTKQQLTHQGHRVYNSSVEKGQQLRQLLLQRYFGHHNNHHPPLDRQQSKIGEVI 1860
Query: 5521 XXXXXXXXXTWSQERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEG 5700
TWSQERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEG
Sbjct: 1861 EAVKEKKEETWSQERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEG 1920
Query: 5701 NDKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRLKSDMMSCSDSKPKVSLSATVSRRS 5880
NDKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRLKSDMMSCSDSKPKV S
Sbjct: 1921 NDKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRLKSDMMSCSDSKPKV---------S 1971
Query: 5881 STVLTPLIDAGDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDA 6060
STVLTPLIDAGDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDA
Sbjct: 1972 STVLTPLIDAGDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDA 2031
Query: 6061 LPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSL 6240
LPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSL
Sbjct: 2032 LPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSL 2091
Query: 6241 GVFGEIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADD 6420
GVFGEIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADD
Sbjct: 2092 GVFGEIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADD 2151
Query: 6421 HMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSN 6600
HMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSN
Sbjct: 2152 HMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSN 2211
Query: 6601 HHMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDK 6780
HHMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDK
Sbjct: 2212 HHMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDK 2271
Query: 6781 FNDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQ 6960
FNDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQ
Sbjct: 2272 FNDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQ 2331
Query: 6961 IEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMI 7140
IEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMI
Sbjct: 2332 IEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMI 2391
Query: 7141 WQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFA 7320
WQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFA
Sbjct: 2392 WQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFA 2451
Query: 7321 VFSSFLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVA 7500
VFSSFLLAHYLRHDKIYLHKT IGVTLTLYIFGILQLVNKIVHVVA
Sbjct: 2452 VFSSFLLAHYLRHDKIYLHKTSLLILASLCFLLLSSIGVTLTLYIFGILQLVNKIVHVVA 2511
Query: 7501 FVSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVI 7680
FVSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVI
Sbjct: 2512 FVSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVI 2571
Query: 7681 ASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSETC 7860
ASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSETC
Sbjct: 2572 ASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSETC 2631
Query: 7861 PSEGCPGLQPSXXXXXXXXXXXXSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMF 8040
PSEGCPGLQPS SCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMF
Sbjct: 2632 PSEGCPGLQPSEKDDNDDEKKVKSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMF 2691
Query: 8041 IWRVAYDMTXXXXXXXXXXXXXXXXXXDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDN 8220
IWRVAYDMT DTFGDLRAEKNEKEQILKNNCFICGLDRSRFDN
Sbjct: 2692 IWRVAYDMTFFVVLIVIVLNLIFGVIIDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDN 2751
Query: 8221 RSVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSL 8400
RSVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSL
Sbjct: 2752 RSVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSL 2811
Query: 8401 QDSELDTDQSEVKQMKDQLLQMMTLMREIISQNEESRAFMEQFQPR 8538
QDSELDTDQSEVKQMKDQLLQMMTLMREIISQNEESRAFMEQFQPR
Sbjct: 2812 QDSELDTDQSEVKQMKDQLLQMMTLMREIISQNEESRAFMEQFQPR 2857
>gi|7500399|pir||T32550 hypothetical protein F33D4.2a - Caenorhabditis
elegans
Length = 2848
Score = 5417 bits (14051), Expect = 0.0
Identities = 2726/2857 (95%), Positives = 2728/2857 (95%), Gaps = 26/2857 (0%)
Frame = +1
Query: 46 MALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKD 225
MALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKD
Sbjct: 1 MALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKD 60
Query: 226 GRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKERE 405
GRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKERE
Sbjct: 61 GRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKERE 120
Query: 406 ENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWF 585
ENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWF
Sbjct: 121 ENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWF 180
Query: 586 IIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLN 765
IIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLN
Sbjct: 181 IIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLN 240
Query: 766 EPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNR 945
EPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNR
Sbjct: 241 EPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNR 300
Query: 946 PSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNG 1125
PSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNG
Sbjct: 301 PSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNG 360
Query: 1126 RRASL---------IYSKTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPE 1278
R L + +TNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPE
Sbjct: 361 RPPLLSALSQKSRPMLERTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPE 420
Query: 1279 EDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWV 1458
EDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWV
Sbjct: 421 EDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWV 480
Query: 1459 KVICEKNRVDKETFALLPVNPDE------VRDLDFANDACKALRNFIKLIKIGQVISKES 1620
KVICEKNRVDKETFALLPVNPDE VRDLDFANDACKALRNFIKLIKIGQVISKES
Sbjct: 481 KVICEKNRVDKETFALLPVNPDEASQSLNVRDLDFANDACKALRNFIKLIKIGQVISKES 540
Query: 1621 INSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLP 1800
INSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLP
Sbjct: 541 INSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLP 600
Query: 1801 RQGTTXXXXXXXXXXXXXDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQ 1980
RQGTT DSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQ
Sbjct: 601 RQGTTELGPLLSSPSELSDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQ 660
Query: 1981 IGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEA 2160
IGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEA
Sbjct: 661 IGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEA 720
Query: 2161 NKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSNSDDAEHLD 2340
NKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSNSDDAEHLD
Sbjct: 721 NKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSNSDDAEHLD 780
Query: 2341 YYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTR 2520
YYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTR
Sbjct: 781 YYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTR 840
Query: 2521 LMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLA 2700
LMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLA
Sbjct: 841 LMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLA 900
Query: 2701 TVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINE 2880
TVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINE
Sbjct: 901 TVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINE 960
Query: 2881 GPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKT 3060
GPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKT
Sbjct: 961 GPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKT 1020
Query: 3061 KLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASELYDAIYRS 3240
KLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASELYDAIYRS
Sbjct: 1021 KLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASELYDAIYRS 1080
Query: 3241 SGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVS 3420
SGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVS
Sbjct: 1081 SGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVS 1140
Query: 3421 NNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSP 3600
NNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSP
Sbjct: 1141 NNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSP 1200
Query: 3601 RAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYP 3780
RAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYP
Sbjct: 1201 RAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYP 1260
Query: 3781 LIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITL 3960
LIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITL
Sbjct: 1261 LIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITL 1320
Query: 3961 SHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVP 4140
SHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVP
Sbjct: 1321 SHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVP 1380
Query: 4141 EELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDN 4320
EELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDN
Sbjct: 1381 EELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDN 1440
Query: 4321 ASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDH 4500
ASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDH
Sbjct: 1441 ASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDH 1500
Query: 4501 IVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEK 4680
IVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEK
Sbjct: 1501 IVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEK 1560
Query: 4681 LTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGK 4860
LTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGK
Sbjct: 1561 LTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGK 1620
Query: 4861 LRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWI 5040
LRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWI
Sbjct: 1621 LRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWI 1680
Query: 5041 GIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLV 5220
GIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLV
Sbjct: 1681 GIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLV 1740
Query: 5221 EVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTK 5400
EVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTK
Sbjct: 1741 EVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTK 1800
Query: 5401 XXXXXXXXXXXXXX-----------XXRYFGHHNNHHPPLDRQQSXXXXXXXXXXXXXXX 5547
RYFGHHNNHHPPLDRQQS
Sbjct: 1801 QQLTHQGHRVYNSSVEKGQQLRQLLLQRYFGHHNNHHPPLDRQQSKIGEVIEAVKEKKEE 1860
Query: 5548 TWSQERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFY 5727
TWSQERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFY
Sbjct: 1861 TWSQERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFY 1920
Query: 5728 MRMKQKDIHEPFFKAILTRIQTAQNRLKSDMMSCSDSKPKVSLSATVSRRSSTVLTPLID 5907
MRMKQKDIHEPFFKAILTRIQTAQNRLKSDMMSCSDSKPKV SSTVLTPLID
Sbjct: 1921 MRMKQKDIHEPFFKAILTRIQTAQNRLKSDMMSCSDSKPKV---------SSTVLTPLID 1971
Query: 5908 AGDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPEVALVE 6087
AGDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPEVALVE
Sbjct: 1972 AGDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPEVALVE 2031
Query: 6088 PILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFGEIGEH 6267
PILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFGEIGEH
Sbjct: 2032 PILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFGEIGEH 2091
Query: 6268 NFSLITQTLATLTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADDHMELALEIK 6447
NFSLITQTLATLTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADDHMELALEIK
Sbjct: 2092 NFSLITQTLATLTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADDHMELALEIK 2151
Query: 6448 SQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISR 6627
SQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISR
Sbjct: 2152 SQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISR 2211
Query: 6628 DLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSV 6807
DLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSV
Sbjct: 2212 DLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSV 2271
Query: 6808 DPREVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRT 6987
DPREVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRT
Sbjct: 2272 DPREVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRT 2331
Query: 6988 LERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRK 7167
LERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRK
Sbjct: 2332 LERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRK 2391
Query: 7168 WLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFAVFSSFLLAH 7347
WLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFAVFSSFLLAH
Sbjct: 2392 WLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFAVFSSFLLAH 2451
Query: 7348 YLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLED 7527
YLRHDKIYLHKT IGVTLTLYIFGILQLVNKIVHVVAFVSNKGLED
Sbjct: 2452 YLRHDKIYLHKTSLLILASLCFLLLSSIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLED 2511
Query: 7528 RPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQS 7707
RPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQS
Sbjct: 2512 RPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQS 2571
Query: 7708 IVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSETCPSEGCPGLQ 7887
IVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSETCPSEGCPGLQ
Sbjct: 2572 IVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSETCPSEGCPGLQ 2631
Query: 7888 PSXXXXXXXXXXXXSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMT 8067
PS SCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMT
Sbjct: 2632 PSEKDDNDDEKKVKSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMT 2691
Query: 8068 XXXXXXXXXXXXXXXXXXDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHR 8247
DTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHR
Sbjct: 2692 FFVVLIVIVLNLIFGVIIDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHR 2751
Query: 8248 ETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQ 8427
ETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQ
Sbjct: 2752 ETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQ 2811
Query: 8428 SEVKQMKDQLLQMMTLMREIISQNEESRAFMEQFQPR 8538
SEVKQMKDQLLQMMTLMREIISQNEESRAFMEQFQPR
Sbjct: 2812 SEVKQMKDQLLQMMTLMREIISQNEESRAFMEQFQPR 2848
>gi|39593648|emb|CAE61940.1| Hypothetical protein CBG05938
[Caenorhabditis briggsae]
Length = 2841
Score = 4989 bits (12940), Expect = 0.0
Identities = 2487/2848 (87%), Positives = 2618/2848 (91%), Gaps = 2/2848 (0%)
Frame = +1
Query: 1 MDYDYRRRVLERNIGMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLS 180
M+ DYRRRVL+R IGM LPSRKLTIA+SIDHGNNGNLHIGDIISLYTESS+NQEQRGFLS
Sbjct: 1 MELDYRRRVLDRTIGMNLPSRKLTIASSIDHGNNGNLHIGDIISLYTESSTNQEQRGFLS 60
Query: 181 TLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDD 360
TLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDD
Sbjct: 61 TLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDD 120
Query: 361 DLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNA 540
DLMNKL+VAA+KEREENE+EFQKTLGN+IQYGSMVQLLHVKSNKYITVQKNSPAKRERNA
Sbjct: 121 DLMNKLRVAAEKEREENEAEFQKTLGNIIQYGSMVQLLHVKSNKYITVQKNSPAKRERNA 180
Query: 541 MKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSF 720
MKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPN+VSTTQ GHVKSQLHLS
Sbjct: 181 MKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNAVSTTQTGHVKSQLHLSGL 240
Query: 721 NLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPK 900
NLLDHQ+AAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPK
Sbjct: 241 NLLDHQTAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPK 300
Query: 901 QNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYL 1080
NPP DVVFLRMTNRPSAADATSSRALWEVQVVQ+NAYRGGTAKWNK YRFKHLA+DMYL
Sbjct: 301 TNPPKDVVFLRMTNRPSAADATSSRALWEVQVVQSNAYRGGTAKWNKTYRFKHLASDMYL 360
Query: 1081 SAEPSQVQVKPAMNGRRASLIYSKTNNPMA-MYSDGPNGVTNESTDTTQQNIPSVWVLGP 1257
+ E SQ++ KPAMNGRRASLI+SKT +P+A MYSDGPNG N+++D + P+V L P
Sbjct: 361 TVEESQMKAKPAMNGRRASLIHSKTQSPLASMYSDGPNG-GNDTSDASDG--PTVSFLSP 417
Query: 1258 TKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSS 1437
KS+FPE+D LLF+LDPSTFMKSNKEVPRRSYVRLLH + WVHATNA EKQNLH+S+
Sbjct: 418 KKSDFPEDDIKLLFELDPSTFMKSNKEVPRRSYVRLLHHKTASWVHATNANEKQNLHFSN 477
Query: 1438 KNEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKE 1617
KNEKGWVKVICE +RVDKETFALLPVNPDEVRDLDFANDACKALRNFI LIKIG VISKE
Sbjct: 478 KNEKGWVKVICETHRVDKETFALLPVNPDEVRDLDFANDACKALRNFINLIKIGSVISKE 537
Query: 1618 SINSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFL 1797
S+NSTTQLLIDCILFVTNSSDHLADPLKI+DFSPSRDRQKLLREQEVL+QVFLLLKAPF
Sbjct: 538 SLNSTTQLLIDCILFVTNSSDHLADPLKITDFSPSRDRQKLLREQEVLHQVFLLLKAPFQ 597
Query: 1798 PRQGTTXXXXXXXXXXXXXDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQE 1977
PRQG+T DSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQE
Sbjct: 598 PRQGSTELGPLLGSPADLSDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQE 657
Query: 1978 QIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGE 2157
QIGFDLMAEDTMTAVLHNNPKLLEKYVK PHVERFV+LVRNNRQGKFLDYLADLCVCRGE
Sbjct: 658 QIGFDLMAEDTMTAVLHNNPKLLEKYVKAPHVERFVDLVRNNRQGKFLDYLADLCVCRGE 717
Query: 2158 ANKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSNSDDAEHL 2337
ANKKIQELICTSVLS KHRDIFMDTK+I+GE+E+GW PNFRKLVDIAEGAKSN DD EHL
Sbjct: 718 ANKKIQELICTSVLSDKHRDIFMDTKVINGEVEIGWDPNFRKLVDIAEGAKSNHDDVEHL 777
Query: 2338 DYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFT 2517
DYYRHQLDLLSQMCQEQQYLAIDPP ER LMNISQQLPAELVLQCMSD RLPYDLRGSFT
Sbjct: 778 DYYRHQLDLLSQMCQEQQYLAIDPPVERGLMNISQQLPAELVLQCMSDTRLPYDLRGSFT 837
Query: 2518 RLMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVL 2697
RLMLHLHVVRGSPMSAIRHARLW SIPE+VNVSTYESVSVEAYSDGSRMRIG IAHKVL
Sbjct: 838 RLMLHLHVVRGSPMSAIRHARLWRSIPESVNVSTYESVSVEAYSDGSRMRIGASIAHKVL 897
Query: 2698 ATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIIN 2877
ATVETYLMGLR+Q +ER SVNSSKLTYEIVNLAK+LAQFNFYSFN+LLQLT+NLLAIIN
Sbjct: 898 ATVETYLMGLRDQPTDERHSVNSSKLTYEIVNLAKSLAQFNFYSFNELLQLTKNLLAIIN 957
Query: 2878 EGPATEQVPSHRAMVNAIRNMSKSMMRGGN-KENSKDLAKTPSVTAEEAGRTKEGRALNV 3054
EGP EQVPSH+AMVN IRNMSKSM+RGGN KENSKDLAKTPS++ ++AGR+KEGRAL V
Sbjct: 958 EGPVPEQVPSHQAMVNVIRNMSKSMLRGGNNKENSKDLAKTPSMSTDDAGRSKEGRALIV 1017
Query: 3055 KTKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASELYDAIY 3234
KTKLIVAEILQFVMDVRRDYRITMALSWFKN FPCDEDGSLMHSASINE+MASELYDAIY
Sbjct: 1018 KTKLIVAEILQFVMDVRRDYRITMALSWFKNEFPCDEDGSLMHSASINEKMASELYDAIY 1077
Query: 3235 RSSGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLL 3414
SSGHELHLDG+DGQLLLAILLQMTMSDYPPLTSIALKV FRHFTQYQELLEDLKQVQLL
Sbjct: 1078 HSSGHELHLDGKDGQLLLAILLQMTMSDYPPLTSIALKVLFRHFTQYQELLEDLKQVQLL 1137
Query: 3415 VSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLK 3594
VSN+DVENYRQIDRDLFILKNLTEKSELWVHGDR+HS++TKEV++KE+TTE+DL H L
Sbjct: 1138 VSNDDVENYRQIDRDLFILKNLTEKSELWVHGDRNHSVETKEVEDKEKTTEYDLHMHQLN 1197
Query: 3595 SPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIA 3774
+PRAF+S DSM+A++AV+NEHY + +NE LQLLNRLLI DDRND AVALQELSDKAPLIA
Sbjct: 1198 TPRAFESRDSMDAVIAVINEHYSNFKNESLQLLNRLLINDDRNDEAVALQELSDKAPLIA 1257
Query: 3775 YPLIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLI 3954
YPLIRQMLVRL MCYR G KPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDH+MMKLI
Sbjct: 1258 YPLIRQMLVRLKRMCYRDG--KPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHEMMKLI 1315
Query: 3955 TLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASN 4134
TLSHEFLR FCK NKENQSRLYKFISYEKDAKEGMLRVET+EEVGTLVAIFRNNRELASN
Sbjct: 1316 TLSHEFLRDFCKANKENQSRLYKFISYEKDAKEGMLRVETVEEVGTLVAIFRNNRELASN 1375
Query: 4135 VPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYV 4314
VPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYV
Sbjct: 1376 VPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYV 1435
Query: 4315 DNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPM 4494
DNASFEELEAMMK EKES+GR ++SR+ LKYHIELVRLLAMCTRGKNGNTELKCASQIPM
Sbjct: 1436 DNASFEELEAMMKQEKESRGRETESRKPLKYHIELVRLLAMCTRGKNGNTELKCASQIPM 1495
Query: 4495 DHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRV 4674
DHIVRVVT+K CLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVD+ILNNLLEDIRSLR+
Sbjct: 1496 DHIVRVVTSKHCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDNILNNLLEDIRSLRI 1555
Query: 4675 EKLTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEK 4854
++LT AET LEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELT LE+
Sbjct: 1556 DRLTDAETVALEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTSLER 1615
Query: 4855 GKLRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAK 5034
GKL+ ++SSRNWYRVAECIKRLTKWAEEH I+LPATL GPQMS +VRQKWQ AA+SAK
Sbjct: 1616 GKLKSTRSSRNWYRVAECIKRLTKWAEEH-ISLPATLVGPQMSATATVRQKWQNAATSAK 1674
Query: 5035 WIGIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSV 5214
IG+ KRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSV
Sbjct: 1675 LIGLNKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSV 1734
Query: 5215 LVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDC 5394
LVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLC+RVLQTLCKMCDC
Sbjct: 1735 LVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCSRVLQTLCKMCDC 1794
Query: 5395 TKXXXXXXXXXXXXXXXXRYFGHHNNHHPPLDRQQSXXXXXXXXXXXXXXXTWSQERDLY 5574
TK RYFGHHN+HHPPLDRQQS TWSQERDLY
Sbjct: 1795 TKQQLTQQGQQLRHLLLQRYFGHHNHHHPPLDRQQSKIGEVVEAVKEKKEETWSQERDLY 1854
Query: 5575 AIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIH 5754
AIQCKLNDAGASDLV DIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIH
Sbjct: 1855 AIQCKLNDAGASDLVIDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIH 1914
Query: 5755 EPFFKAILTRIQTAQNRLKSDMMSCSDSKPKVSLSATVSRRSSTVLTPLIDAGDTGFNGA 5934
EPFFK ILTRIQTAQNRLKSDMMSCSDSKPK SLSATVSRRSSTVLTPLIDAGDTGFNG
Sbjct: 1915 EPFFKVILTRIQTAQNRLKSDMMSCSDSKPKPSLSATVSRRSSTVLTPLIDAGDTGFNGT 1974
Query: 5935 LFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPEVALVEPILRVLQLL 6114
LFEVPQQVRHPSISEMSQLSNDLTHSIPDL PYQDE+KS DALPPEVALVEPILRVLQLL
Sbjct: 1975 LFEVPQQVRHPSISEMSQLSNDLTHSIPDLTPYQDEDKSADALPPEVALVEPILRVLQLL 2034
Query: 6115 CENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFGEIGEHNFSLITQTL 6294
CENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFGEIGEHNFSLITQTL
Sbjct: 2035 CENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFGEIGEHNFSLITQTL 2094
Query: 6295 ATLTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLA 6474
ATLTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLA
Sbjct: 2095 ATLTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLA 2154
Query: 6475 IMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDD 6654
IMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMT SNHHMLKS+SRDL R+AEDD
Sbjct: 2155 IMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTRSNHHMLKSVSRDLLRRAEDD 2214
Query: 6655 LKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNI 6834
K KSGPQITVNT+TLPEINVDASGIVSIHTEK+ISSSLDDKF++DD PSVDPREVGHNI
Sbjct: 2215 SKSKSGPQITVNTITLPEINVDASGIVSIHTEKSISSSLDDKFHEDDSPSVDPREVGHNI 2274
Query: 6835 YILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPIN 7014
YILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPIN
Sbjct: 2275 YILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPIN 2334
Query: 7015 DICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRL 7194
+ICS+LTK+TKDYVYNNTERDNQGSKVTEFFD+WETMYHEMIWQRKLQDRKWLSWCA RL
Sbjct: 2335 EICSFLTKETKDYVYNNTERDNQGSKVTEFFDQWETMYHEMIWQRKLQDRKWLSWCAVRL 2394
Query: 7195 PLWTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFAVFSSFLLAHYLRHDKIYL 7374
PLWTRLSF FAFIVNALVA YYP PE ++SSIS GNLYSW AV S+FLLAH+LRH+K YL
Sbjct: 2395 PLWTRLSFQFAFIVNALVALYYPFPESTSSSISFGNLYSWLAVISAFLLAHFLRHEKAYL 2454
Query: 7375 HKTXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILAC 7554
KT IGV LTLY FG+LQ +NK++HV+AFVSNKGLEDRP++EIL C
Sbjct: 2455 SKTALLILSSLCFLLVNSIGVNLTLYFFGMLQAINKVIHVLAFVSNKGLEDRPLSEILGC 2514
Query: 7555 RNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLAL 7734
RNLHYLLVYL +CI G ++HPMIYC LLFDII TEETLQNVIASVTRNYQSIVWTGLLAL
Sbjct: 2515 RNLHYLLVYLTVCIAGFVIHPMIYCALLFDIIATEETLQNVIASVTRNYQSIVWTGLLAL 2574
Query: 7735 ILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSETCPSEGCPGLQPSXXXXXXX 7914
ILLY FSILGFL+FRHDFYLEVDPVE DS A+IS +P++TCP EGCPGL+
Sbjct: 2575 ILLYIFSILGFLFFRHDFYLEVDPVEPDSPASISGALPTDTCPKEGCPGLE-RTKDNDDD 2633
Query: 7915 XXXXXSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTXXXXXXXXX 8094
SCETLWMCILQT Y GLRNGGGIGDVLRNPAPWEDMF+WRVAYDMT
Sbjct: 2634 DKKVKSCETLWMCILQTMYLGLRNGGGIGDVLRNPAPWEDMFVWRVAYDMTFFVVLIVIV 2693
Query: 8095 XXXXXXXXXDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHY 8274
DTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFE+HRE EHNIWHY
Sbjct: 2694 LNLIFGVIIDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFESHREMEHNIWHY 2753
Query: 8275 LYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQ 8454
LYYIVMLQIKDETEFTGPESYVAQCVK+RNLDWFPRMQALSLQDSELDTDQSE+KQMKDQ
Sbjct: 2754 LYYIVMLQIKDETEFTGPESYVAQCVKERNLDWFPRMQALSLQDSELDTDQSEMKQMKDQ 2813
Query: 8455 LLQMMTLMREIISQNEESRAFMEQFQPR 8538
++QMM +MRE SQ +E RAFMEQ Q R
Sbjct: 2814 MMQMMAMMRENQSQWDEVRAFMEQLQSR 2841
>gi|10636263|emb|CAC10528.1| putative inositol 1,4,5-trisphosphate
receptor [Caenorhabditis briggsae]
Length = 2933
Score = 4937 bits (12805), Expect = 0.0
Identities = 2473/2885 (85%), Positives = 2607/2885 (89%), Gaps = 40/2885 (1%)
Frame = +1
Query: 4 DYDYRRRVLERNIGMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLST 183
D+D + R M LPSRKLTIA+SIDHGNNGNLHIGDIISLYTESS+NQEQRGFLST
Sbjct: 55 DFDDFEEQIMRKSSMNLPSRKLTIASSIDHGNNGNLHIGDIISLYTESSTNQEQRGFLST 114
Query: 184 LGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDD 363
LGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDD
Sbjct: 115 LGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDD 174
Query: 364 LMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAM 543
LMNKL+VAA+KEREENE+EFQKTLGN+IQYGSMVQLLHVKSNKYITVQKNSPAKRERNAM
Sbjct: 175 LMNKLRVAAEKEREENEAEFQKTLGNIIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAM 234
Query: 544 KVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFN 723
KVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPN+VSTTQ GHVKSQLHLS N
Sbjct: 235 KVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNAVSTTQTGHVKSQLHLSGLN 294
Query: 724 LLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQ 903
LLDHQ+AAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPK
Sbjct: 295 LLDHQTAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKT 354
Query: 904 NPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLS 1083
NPP DVVFLRMTNRPSAADATSSRALWEVQVVQ+NAYRGGTAKWNK YRFKHLA+DMYL+
Sbjct: 355 NPPKDVVFLRMTNRPSAADATSSRALWEVQVVQSNAYRGGTAKWNKTYRFKHLASDMYLT 414
Query: 1084 AEPSQVQVKPAMNGR--------RASLIYSKTNNPMA-MYSDGPNGVTNESTDTTQQNIP 1236
E SQ++ KPAMNGR + S I +T +P+A MYSDGPNG N+++D + P
Sbjct: 415 VEESQMKAKPAMNGRPPLLSTLSQKSKILERTQSPLASMYSDGPNG-GNDTSDASDG--P 471
Query: 1237 SVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEK 1416
+V L P KS+FPE+D LLF+LDPSTFMKSNKEVPRRSYVRLLH + WVHATNA EK
Sbjct: 472 TVSFLSPKKSDFPEDDIKLLFELDPSTFMKSNKEVPRRSYVRLLHHKTASWVHATNANEK 531
Query: 1417 QNLHYSSKNEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKI 1596
QNLH+S+KNEKGWVKVICE +RVDKETFALLPVNPDEVRDLDFANDACK LRNFI LIKI
Sbjct: 532 QNLHFSNKNEKGWVKVICETHRVDKETFALLPVNPDEVRDLDFANDACKXLRNFINLIKI 591
Query: 1597 GQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFL 1776
G VISKES+NSTTQLLIDCILFVTNSSDHLADPLKI+DFSPSRDRQKLLRE+EVL+QVFL
Sbjct: 592 GSVISKESLNSTTQLLIDCILFVTNSSDHLADPLKITDFSPSRDRQKLLREEEVLHQVFL 651
Query: 1777 LLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAE 1956
LLKAPF PRQG+T DSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAE
Sbjct: 652 LLKAPFQPRQGSTELGPLLGSPADLSDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAE 711
Query: 1957 KFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLAD 2136
KFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVK PHVERFV+LVRNNRQGKFLDYLAD
Sbjct: 712 KFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKAPHVERFVDLVRNNRQGKFLDYLAD 771
Query: 2137 LCVCRGEANKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSN 2316
LCVCRGEANKKIQELICTSVLS KHRDIFMDTK+I+GE+E+GW PNFRKLVDIAEGAKSN
Sbjct: 772 LCVCRGEANKKIQELICTSVLSDKHRDIFMDTKVINGEVEIGWDPNFRKLVDIAEGAKSN 831
Query: 2317 SDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPY 2496
DD EHLDYYRHQLDLLSQMCQEQQYLAIDPP ER LMNISQQLPAELVLQCMSD RLPY
Sbjct: 832 HDDVEHLDYYRHQLDLLSQMCQEQQYLAIDPPVERGLMNISQQLPAELVLQCMSDTRLPY 891
Query: 2497 DLRGSFTRLMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGE 2676
DLRGSFTRLMLHLHVVRGSPMSAIRHARLW SIPE+VNVSTYESVSVEAYSDGSRMRIG
Sbjct: 892 DLRGSFTRLMLHLHVVRGSPMSAIRHARLWRSIPESVNVSTYESVSVEAYSDGSRMRIGA 951
Query: 2677 GIAHKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQ 2856
IAHKVLATVETYLMGLR+Q +ER SVNSSKLTYEIVNLAK+LAQFNFYSFN+LLQLT+
Sbjct: 952 SIAHKVLATVETYLMGLRDQPTDERHSVNSSKLTYEIVNLAKSLAQFNFYSFNELLQLTK 1011
Query: 2857 NLLAIINEGPATEQVPSHRAMVNAIRNMSKSMMRGG-NKENSKDLAKTPSVTAEEAGRTK 3033
NLLAIINEGP EQVPSH+AMVN IRNMSKSM+RGG NKENSKDLAKTPS++ ++AGR+K
Sbjct: 1012 NLLAIINEGPVPEQVPSHQAMVNVIRNMSKSMLRGGNNKENSKDLAKTPSMSTDDAGRSK 1071
Query: 3034 EGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMAS 3213
EGRAL VKTKLIVAEILQFVMDVRRDYRITMALSWFKN FPCDEDGSLMHSASINE+MAS
Sbjct: 1072 EGRALIVKTKLIVAEILQFVMDVRRDYRITMALSWFKNEFPCDEDGSLMHSASINEKMAS 1131
Query: 3214 ELYDAIYRSSGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLED 3393
ELYDAIY SSGHELHLDG+DGQLLLAILLQMTMSDYPPLTSIALKV FRHFTQYQELLED
Sbjct: 1132 ELYDAIYHSSGHELHLDGKDGQLLLAILLQMTMSDYPPLTSIALKVLFRHFTQYQELLED 1191
Query: 3394 LKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHD 3573
LKQVQLLVSN+DVENYRQIDRDLFILKNLTEKSELWVHGDR+HS++TKEV++KE+TTE+D
Sbjct: 1192 LKQVQLLVSNDDVENYRQIDRDLFILKNLTEKSELWVHGDRNHSVETKEVEDKEKTTEYD 1251
Query: 3574 LLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELS 3753
L H L +PRAF+S DSM+A++AV+NEHY + +NE LQLLNRLLI DDRND AVALQELS
Sbjct: 1252 LHMHQLNTPRAFESRDSMDAVIAVINEHYSNFKNESLQLLNRLLINDDRNDEAVALQELS 1311
Query: 3754 DKAPLIAYPLIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHD 3933
DKAPLIAYPLIRQMLVRL MCYR G KPDTMNQQLLKNMRVYEVVLEFISVPHDKKHD
Sbjct: 1312 DKAPLIAYPLIRQMLVRLKRMCYRDG--KPDTMNQQLLKNMRVYEVVLEFISVPHDKKHD 1369
Query: 3934 HDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRN 4113
H+MMKLITLSHEFLR FCK NKENQSRLYKFISYEKDAKEGMLRVET+EEVGTLVAIFRN
Sbjct: 1370 HEMMKLITLSHEFLRDFCKANKENQSRLYKFISYEKDAKEGMLRVETVEEVGTLVAIFRN 1429
Query: 4114 NRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASD 4293
NRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASD
Sbjct: 1430 NRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASD 1489
Query: 4294 EVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELK 4473
EVRQLYVDNASFEELEAMMK EKES+GR ++SR+ LKYHIELVRLLAMCTRGKNGNTELK
Sbjct: 1490 EVRQLYVDNASFEELEAMMKQEKESRGRETESRKPLKYHIELVRLLAMCTRGKNGNTELK 1549
Query: 4474 CASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLE 4653
CASQIPMDHIVRVVT+K CLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVD+ILNNLLE
Sbjct: 1550 CASQIPMDHIVRVVTSKHCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDNILNNLLE 1609
Query: 4654 DIRSLRVEKLTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLL 4833
DIRSLR+++LT AET LEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLL
Sbjct: 1610 DIRSLRIDRLTDAETVALEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLL 1669
Query: 4834 ELTYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQ 5013
ELT LE+GKL+ ++SSRNWYRVAECIKRLTKWAEEH+I+LPATL GPQMS +VRQKWQ
Sbjct: 1670 ELTSLERGKLKSTRSSRNWYRVAECIKRLTKWAEEHSISLPATLVGPQMSATATVRQKWQ 1729
Query: 5014 QAASSAKWIGIGK--------RLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGE 5169
AA+SAK IG+ K RLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGE
Sbjct: 1730 NAATSAKLIGLNKPVITLVVERLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGE 1789
Query: 5170 FKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDN 5349
FKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDN
Sbjct: 1790 FKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDN 1849
Query: 5350 LCARVLQTLCKMCDCTKXXXXXXXXXXXXXX----------------------XXRYFGH 5463
LC+RVLQTLCKMCDCTK RYFGH
Sbjct: 1850 LCSRVLQTLCKMCDCTKQQLTQQGRRFYNSSFEKGRRFYNSSFEKGQQLRHLLLQRYFGH 1909
Query: 5464 HNNHHPPLDRQQSXXXXXXXXXXXXXXXTWSQERDLYAIQCKLNDAGASDLVTDIIIMEP 5643
HN+HHPPLDRQQS TWSQERDLYAIQCKLNDAGASDLV DIIIMEP
Sbjct: 1910 HNHHHPPLDRQQSKIGEVVEAVKEKKEETWSQERDLYAIQCKLNDAGASDLVIDIIIMEP 1969
Query: 5644 SREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRLKSDMM 5823
SREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEPFFK ILTRIQTAQNRLKSDMM
Sbjct: 1970 SREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEPFFKVILTRIQTAQNRLKSDMM 2029
Query: 5824 SCSDSKPKVSLSATVSRRSSTVLTPLIDAGDTGFNGALFEVPQQVRHPSISEMSQLSNDL 6003
SCSDSKPK SLSATVSRRSSTVLTPLIDAGDTGFNG LFEVPQQVRHPSISEMSQLSNDL
Sbjct: 2030 SCSDSKPKPSLSATVSRRSSTVLTPLIDAGDTGFNGTLFEVPQQVRHPSISEMSQLSNDL 2089
Query: 6004 THSIPDLAPYQDEEKSTDALPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNL 6183
THSIPDL PYQDE+KS DALPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNL
Sbjct: 2090 THSIPDLTPYQDEDKSADALPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNL 2149
Query: 6184 VSETLSFLDTVCGSTKGSLGVFGEIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQEN 6363
VSETLSFLDTVCGSTKGSLGVFGEIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQEN
Sbjct: 2150 VSETLSFLDTVCGSTKGSLGVFGEIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQEN 2209
Query: 6364 GLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSG 6543
GLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSG
Sbjct: 2210 GLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSG 2269
Query: 6544 GPKQLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDA 6723
GP+QLVHAIKQAYEMT SNHHMLKS+SRDL R+AEDD K KSGPQITVNT+TLPEINVDA
Sbjct: 2270 GPQQLVHAIKQAYEMTRSNHHMLKSVSRDLLRRAEDDSKSKSGPQITVNTITLPEINVDA 2329
Query: 6724 SGIVSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSDE 6903
SGIVSIHTEK+ISSSLDDKF++DD PSVDPREVGHNIYILAHQLAIHDGELEIWLDGSDE
Sbjct: 2330 SGIVSIHTEKSISSSLDDKFHEDDSPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSDE 2389
Query: 6904 KKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQ 7083
KKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPIN+ICS+LTK+TKDYVYNNTERDNQ
Sbjct: 2390 KKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPINEICSFLTKETKDYVYNNTERDNQ 2449
Query: 7084 GSKVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYP 7263
GSKVTEFFD+WETMYHEMIWQRKLQDRKWLSWCA RLPLWTRLSF FAFIVNALVA YYP
Sbjct: 2450 GSKVTEFFDQWETMYHEMIWQRKLQDRKWLSWCAVRLPLWTRLSFQFAFIVNALVALYYP 2509
Query: 7264 LPEHSNSSISLGNLYSWFAVFSSFLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTL 7443
PE ++SSIS GNLYSW AV S+FLLAH+LRH+K YL KT IGV L
Sbjct: 2510 FPESTSSSISFGNLYSWLAVISAFLLAHFLRHEKAYLSKTALLILSSLCFLLVNSIGVNL 2569
Query: 7444 TLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMI 7623
TLY FG+LQLVNK++HV+AFVSNKGLEDRP++EIL CRNLHYLLVYL +CI G ++HPMI
Sbjct: 2570 TLYFFGMLQLVNKVIHVLAFVSNKGLEDRPLSEILGCRNLHYLLVYLTVCIAGFVIHPMI 2629
Query: 7624 YCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVD 7803
YC LLFDII TEETLQNVIASVTRNYQSIVWTGLLALILLY FSILGFL+FRHDFYLEVD
Sbjct: 2630 YCALLFDIIATEETLQNVIASVTRNYQSIVWTGLLALILLYIFSILGFLFFRHDFYLEVD 2689
Query: 7804 PVENDSSATISSGIPSETCPSEGCPGLQPSXXXXXXXXXXXXSCETLWMCILQTGYQGLR 7983
PVE DS A+IS +P++TCP EGCPGL+ SCETLWMCILQT Y GLR
Sbjct: 2690 PVEPDSPASISGALPTDTCPKEGCPGLE-RTKDNDDDDKKVKSCETLWMCILQTMYLGLR 2748
Query: 7984 NGGGIGDVLRNPAPWEDMFIWRVAYDMTXXXXXXXXXXXXXXXXXXDTFGDLRAEKNEKE 8163
NGGGIGDVLRNPAPWEDMF+WRVAYDMT DTFGDLRAEKNEKE
Sbjct: 2749 NGGGIGDVLRNPAPWEDMFVWRVAYDMTFFVVLIVIVLNLIFGVIIDTFGDLRAEKNEKE 2808
Query: 8164 QILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPESYVA 8343
QILKNNCFICGLDRSRFDNRSVTFE+HRE EHNIWHYLYYIVMLQIKDETEFTGPESYVA
Sbjct: 2809 QILKNNCFICGLDRSRFDNRSVTFESHREMEHNIWHYLYYIVMLQIKDETEFTGPESYVA 2868
Query: 8344 QCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLLQMMTLMREIISQNEESRAFME 8523
QCVK+RNLDWFPRMQALSLQDSELDTDQSE+KQMKDQ++QMM +MRE SQ +E RAFME
Sbjct: 2869 QCVKERNLDWFPRMQALSLQDSELDTDQSEMKQMKDQMMQMMAMMRENQSQWDEVRAFME 2928
Query: 8524 QFQPR 8538
Q Q R
Sbjct: 2929 QLQSR 2933
>gi|7500401|pir||T32552 hypothetical protein F33D4.2c - Caenorhabditis
elegans
Length = 1966
Score = 3744 bits (9709), Expect = 0.0
Identities = 1884/1950 (96%), Positives = 1886/1950 (96%), Gaps = 15/1950 (0%)
Frame = +1
Query: 46 MALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKD 225
MALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKD
Sbjct: 1 MALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKD 60
Query: 226 GRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKERE 405
GRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKERE
Sbjct: 61 GRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKERE 120
Query: 406 ENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWF 585
ENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWF
Sbjct: 121 ENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWF 180
Query: 586 IIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLN 765
IIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLN
Sbjct: 181 IIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLN 240
Query: 766 EPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNR 945
EPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNR
Sbjct: 241 EPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNR 300
Query: 946 PSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNG 1125
PSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNG
Sbjct: 301 PSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNG 360
Query: 1126 RRASL---------IYSKTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPE 1278
R L + +TNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPE
Sbjct: 361 RPPLLSALSQKSRPMLERTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPE 420
Query: 1279 EDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWV 1458
EDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWV
Sbjct: 421 EDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWV 480
Query: 1459 KVICEKNRVDKETFALLPVNPDE------VRDLDFANDACKALRNFIKLIKIGQVISKES 1620
KVICEKNRVDKETFALLPVNPDE VRDLDFANDACKALRNFIKLIKIGQVISKES
Sbjct: 481 KVICEKNRVDKETFALLPVNPDEASQSLNVRDLDFANDACKALRNFIKLIKIGQVISKES 540
Query: 1621 INSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLP 1800
INSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLP
Sbjct: 541 INSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLP 600
Query: 1801 RQGTTXXXXXXXXXXXXXDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQ 1980
RQGTT DSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQ
Sbjct: 601 RQGTTELGPLLSSPSELSDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQ 660
Query: 1981 IGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEA 2160
IGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEA
Sbjct: 661 IGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEA 720
Query: 2161 NKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSNSDDAEHLD 2340
NKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSNSDDAEHLD
Sbjct: 721 NKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSNSDDAEHLD 780
Query: 2341 YYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTR 2520
YYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTR
Sbjct: 781 YYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTR 840
Query: 2521 LMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLA 2700
LMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLA
Sbjct: 841 LMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLA 900
Query: 2701 TVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINE 2880
TVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINE
Sbjct: 901 TVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINE 960
Query: 2881 GPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKT 3060
GPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKT
Sbjct: 961 GPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKT 1020
Query: 3061 KLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASELYDAIYRS 3240
KLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASELYDAIYRS
Sbjct: 1021 KLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASELYDAIYRS 1080
Query: 3241 SGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVS 3420
SGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVS
Sbjct: 1081 SGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVS 1140
Query: 3421 NNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSP 3600
NNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSP
Sbjct: 1141 NNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSP 1200
Query: 3601 RAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYP 3780
RAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYP
Sbjct: 1201 RAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYP 1260
Query: 3781 LIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITL 3960
LIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITL
Sbjct: 1261 LIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITL 1320
Query: 3961 SHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVP 4140
SHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVP
Sbjct: 1321 SHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVP 1380
Query: 4141 EELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDN 4320
EELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDN
Sbjct: 1381 EELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDN 1440
Query: 4321 ASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDH 4500
ASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDH
Sbjct: 1441 ASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDH 1500
Query: 4501 IVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEK 4680
IVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEK
Sbjct: 1501 IVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEK 1560
Query: 4681 LTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGK 4860
LTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGK
Sbjct: 1561 LTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGK 1620
Query: 4861 LRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWI 5040
LRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWI
Sbjct: 1621 LRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWI 1680
Query: 5041 GIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLV 5220
GIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLV
Sbjct: 1681 GIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLV 1740
Query: 5221 EVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTK 5400
EVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTK
Sbjct: 1741 EVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTK 1800
Query: 5401 XXXXXXXXXXXXXXXXRYFGHHNNHHPPLDRQQSXXXXXXXXXXXXXXXTWSQERDLYAI 5580
RYFGHHNNHHPPLDRQQS TWSQERDLYAI
Sbjct: 1801 QQLTHQGQQLRQLLLQRYFGHHNNHHPPLDRQQSKIGEVIEAVKEKKEETWSQERDLYAI 1860
Query: 5581 QCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEP 5760
QCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEP
Sbjct: 1861 QCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEP 1920
Query: 5761 FFKAILTRIQTAQNRLKSDMMSCSDSKPKV 5850
FFKAILTRIQTAQNRLKSDMMSCSDSKPKV
Sbjct: 1921 FFKAILTRIQTAQNRLKSDMMSCSDSKPKV 1950
>gi|14574165|gb|AAK68363.1| Inositol triphosphate receptor protein 1,
isoform c [Caenorhabditis elegans]
Length = 1862
Score = 3600 bits (9335), Expect = 0.0
Identities = 1805/1845 (97%), Positives = 1805/1845 (97%), Gaps = 11/1845 (0%)
Frame = +1
Query: 1 MDYDYRRRVLERNIGMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLS 180
MDYDYRRRVLERNIGMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLS
Sbjct: 1 MDYDYRRRVLERNIGMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLS 60
Query: 181 TLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDD 360
TLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDD
Sbjct: 61 TLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDD 120
Query: 361 DLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNA 540
DLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNA
Sbjct: 121 DLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNA 180
Query: 541 MKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSF 720
MKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSF
Sbjct: 181 MKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSF 240
Query: 721 NLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPK 900
NLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPK
Sbjct: 241 NLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPK 300
Query: 901 QNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYL 1080
QNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYL
Sbjct: 301 QNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYL 360
Query: 1081 SAEPSQVQVKPAMNGRRASLIYSKTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPT 1260
SAEPSQVQVKPAMNGRRASLIYSKTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPT
Sbjct: 361 SAEPSQVQVKPAMNGRRASLIYSKTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPT 420
Query: 1261 KSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSK 1440
KSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSK
Sbjct: 421 KSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSK 480
Query: 1441 NEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKES 1620
NEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKES
Sbjct: 481 NEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKES 540
Query: 1621 INSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLP 1800
INSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLP
Sbjct: 541 INSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLP 600
Query: 1801 RQGTTXXXXXXXXXXXXXDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQ 1980
RQGTT DSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQ
Sbjct: 601 RQGTTELGPLLSSPSELSDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQ 660
Query: 1981 IGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEA 2160
IGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEA
Sbjct: 661 IGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEA 720
Query: 2161 NKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSNSDDAEHLD 2340
NKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSNSDDAEHLD
Sbjct: 721 NKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSNSDDAEHLD 780
Query: 2341 YYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTR 2520
YYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTR
Sbjct: 781 YYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTR 840
Query: 2521 LMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLA 2700
LMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLA
Sbjct: 841 LMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLA 900
Query: 2701 TVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINE 2880
TVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINE
Sbjct: 901 TVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINE 960
Query: 2881 GPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKT 3060
GPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKT
Sbjct: 961 GPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKT 1020
Query: 3061 KLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASELYDAIYRS 3240
KLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASELYDAIYRS
Sbjct: 1021 KLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASELYDAIYRS 1080
Query: 3241 SGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVS 3420
SGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVS
Sbjct: 1081 SGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVS 1140
Query: 3421 NNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSP 3600
NNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSP
Sbjct: 1141 NNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSP 1200
Query: 3601 RAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYP 3780
RAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYP
Sbjct: 1201 RAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYP 1260
Query: 3781 LIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITL 3960
LIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITL
Sbjct: 1261 LIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITL 1320
Query: 3961 SHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVP 4140
SHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVP
Sbjct: 1321 SHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVP 1380
Query: 4141 EELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDN 4320
EELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDN
Sbjct: 1381 EELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDN 1440
Query: 4321 ASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDH 4500
ASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDH
Sbjct: 1441 ASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDH 1500
Query: 4501 IVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEK 4680
IVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEK
Sbjct: 1501 IVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEK 1560
Query: 4681 LTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGK 4860
LTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGK
Sbjct: 1561 LTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGK 1620
Query: 4861 LRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWI 5040
LRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWI
Sbjct: 1621 LRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWI 1680
Query: 5041 GIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLV 5220
GIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLV
Sbjct: 1681 GIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLV 1740
Query: 5221 EVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTK 5400
EVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTK
Sbjct: 1741 EVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTK 1800
Query: 5401 XXXXXXXXXXXXXX-----------XXRYFGHHNNHHPPLDRQQS 5502
RYFGHHNNHHPPLDRQQS
Sbjct: 1801 QQLTHQGHRVYNSSVEKGQQLRQLLLQRYFGHHNNHHPPLDRQQS 1845
>gi|22532932|gb|AAM98028.1| Inositol triphosphate receptor protein 1,
isoform g [Caenorhabditis elegans]
Length = 1713
Score = 3330 bits (8633), Expect(2) = 0.0
Identities = 1671/1684 (99%), Positives = 1671/1684 (99%)
Frame = +1
Query: 1 MDYDYRRRVLERNIGMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLS 180
MDYDYRRRVLERNIGMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLS
Sbjct: 1 MDYDYRRRVLERNIGMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLS 60
Query: 181 TLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDD 360
TLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDD
Sbjct: 61 TLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDD 120
Query: 361 DLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNA 540
DLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNA
Sbjct: 121 DLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNA 180
Query: 541 MKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSF 720
MKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSF
Sbjct: 181 MKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSF 240
Query: 721 NLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPK 900
NLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPK
Sbjct: 241 NLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPK 300
Query: 901 QNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYL 1080
QNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYL
Sbjct: 301 QNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYL 360
Query: 1081 SAEPSQVQVKPAMNGRRASLIYSKTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPT 1260
SAEPSQVQVKPAMNGRRASLIYSKTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPT
Sbjct: 361 SAEPSQVQVKPAMNGRRASLIYSKTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPT 420
Query: 1261 KSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSK 1440
KSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSK
Sbjct: 421 KSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSK 480
Query: 1441 NEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKES 1620
NEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKES
Sbjct: 481 NEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKES 540
Query: 1621 INSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLP 1800
INSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLP
Sbjct: 541 INSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLP 600
Query: 1801 RQGTTXXXXXXXXXXXXXDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQ 1980
RQGTT DSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQ
Sbjct: 601 RQGTTELGPLLSSPSELSDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQ 660
Query: 1981 IGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEA 2160
IGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEA
Sbjct: 661 IGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEA 720
Query: 2161 NKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSNSDDAEHLD 2340
NKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSNSDDAEHLD
Sbjct: 721 NKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSNSDDAEHLD 780
Query: 2341 YYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTR 2520
YYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTR
Sbjct: 781 YYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTR 840
Query: 2521 LMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLA 2700
LMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLA
Sbjct: 841 LMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLA 900
Query: 2701 TVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINE 2880
TVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINE
Sbjct: 901 TVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINE 960
Query: 2881 GPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKT 3060
GPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKT
Sbjct: 961 GPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKT 1020
Query: 3061 KLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASELYDAIYRS 3240
KLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASELYDAIYRS
Sbjct: 1021 KLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASELYDAIYRS 1080
Query: 3241 SGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVS 3420
SGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVS
Sbjct: 1081 SGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVS 1140
Query: 3421 NNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSP 3600
NNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSP
Sbjct: 1141 NNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSP 1200
Query: 3601 RAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYP 3780
RAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYP
Sbjct: 1201 RAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYP 1260
Query: 3781 LIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITL 3960
LIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITL
Sbjct: 1261 LIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITL 1320
Query: 3961 SHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVP 4140
SHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVP
Sbjct: 1321 SHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVP 1380
Query: 4141 EELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDN 4320
EELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDN
Sbjct: 1381 EELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDN 1440
Query: 4321 ASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDH 4500
ASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDH
Sbjct: 1441 ASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDH 1500
Query: 4501 IVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEK 4680
IVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEK
Sbjct: 1501 IVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEK 1560
Query: 4681 LTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGK 4860
LTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGK
Sbjct: 1561 LTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGK 1620
Query: 4861 LRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWI 5040
LRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWI
Sbjct: 1621 LRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWI 1680
Query: 5041 GIGK 5052
GIGK
Sbjct: 1681 GIGK 1684
Score = 50.4 bits (119), Expect(2) = 0.0
Identities = 22/22 (100%), Positives = 22/22 (100%)
Frame = +3
Query: 5052 ETQSSKYAQSWSSTLWNIKLYD 5117
ETQSSKYAQSWSSTLWNIKLYD
Sbjct: 1692 ETQSSKYAQSWSSTLWNIKLYD 1713
>gi|10835023|ref|NP_002213.1| inositol 1,4,5-triphosphate receptor,
type 1 [Homo sapiens]
gi|1085408|pir||S54974 type 1 inositol 1,4,5-trisphosphate receptor -
human
gi|559323|dbj|BAA05065.1| human type 1 inositol 1,4,5-trisphosphate
receptor [Homo sapiens]
Length = 2695
Score = 1658 bits (4294), Expect = 0.0
Identities = 1062/2911 (36%), Positives = 1566/2911 (53%), Gaps = 105/2911 (3%)
Frame = +1
Query: 109 LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
LHIGDI SLY E S+N GF+STLGLVDDRC+V+ + G +PPKKFRDCLFK+CP+N
Sbjct: 9 LHIGDICSLYAEGSTN----GFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKLCPMN 64
Query: 289 RYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQ 468
RY+AQK W K +S D L+NKL AAD E+++NE+E +K LG VIQYG+++Q
Sbjct: 65 RYSAQKQFWKAAK--PGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQ 122
Query: 469 LLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKI 648
LLH+KSNKY+TV K PA E+NAM+V LD AGNEGSWF I+P YK +IGD+V G+K+
Sbjct: 123 LLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGDKV 182
Query: 649 SLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSV 828
L P AG LH SS L+D+ EVN +N T W++ +F+ + +N+ + +
Sbjct: 183 VLNP-----VNAGQ---PLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDIL 234
Query: 829 KSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTN 1008
K GDVVRLFHA+Q+ FLT D K+ VFLR T R SA ATSS+ALWEV+VVQ +
Sbjct: 235 KGGDVVRLFHAEQEKFLTCDEHRKKQH----VFLRTTGRQSATSATSSKALWEVEVVQHD 290
Query: 1009 AYRGGTAKWNKAYRFKHLATDMYLSAE--PSQVQVKPAMNGRRASLIYSKTNNPMAMYSD 1182
RGG WN +RFKHLAT YL+AE P Q + + + ++YS + P
Sbjct: 291 PCRGGAGYWNSLFRFKHLATGHYLAAEVDPDQDASRSRLRNAQEKMVYSLVSVPEG---- 346
Query: 1183 GPNGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVR 1362
D + +F+LDP+T + VPR SYVR
Sbjct: 347 --------------------------------NDISSIFELDPTTLRGGDSLVPRNSYVR 374
Query: 1363 LLHQSSDKWVHATNATEKQNLHYSSKNEKG-WVKVICEKNRVDKETFALLPVNPDEVRDL 1539
L H ++ WVH+TN + + EK +K+ + DKE FA++PV+P EVRDL
Sbjct: 375 LRHLCTNTWVHSTN------IPIDKEEEKPVMLKIGTSPVKEDKEAFAIVPVSPAEVRDL 428
Query: 1540 DFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSP 1719
DFANDA K L + ++ G + E S T+LL D + FVT ++ D L++ P
Sbjct: 429 DFANDASKVLGSIAGKLEKGTITQNER-RSVTKLLEDLVYFVTGGTNSGQDVLEVVFSKP 487
Query: 1720 SRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIFKTMFQLCY 1899
+R+RQKL+REQ +L Q+F LL+APF T D R+ F+ + +LCY
Sbjct: 488 NRERQKLMREQNILKQIFKLLQAPF-----TDCGDGPMLRLEELGDQRHAPFRHICRLCY 542
Query: 1900 CLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVER 2079
+L++SQ YRKNQE++A++FG +Q+QIG+D++AEDT+TA+LHNN KLLEK++ ++
Sbjct: 543 RVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKHITAAEIDT 602
Query: 2080 FVELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKII------ 2241
FV LVR NR+ +FLDYL+DLCV ++ QELIC +VL+ + DI ++TK++
Sbjct: 603 FVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETKLVLSRFEF 662
Query: 2242 ----------------DGEIEVGWAPNFRKLV-----DIAEGAKSNS-DDAEHLDYYRHQ 2355
+ E+ + W + +++ ++A+ AK +D + L YYR+Q
Sbjct: 663 EGVSSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDAKEGQKEDRDVLSYYRYQ 722
Query: 2356 LDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLHL 2535
L+L ++MC ++QYLAI+ IS QL +L+L+CMSD LPYDLR SF RLMLH+
Sbjct: 723 LNLFARMCLDRQYLAIN--------EISGQLDVDLILRCMSDENLPYDLRASFCRLMLHM 774
Query: 2536 HVVRG--SPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATVE 2709
HV R ++ +++ARLW IP + + Y+S S S+ I E A + + VE
Sbjct: 775 HVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDS------SGASKDEIKERFA-QTMEFVE 827
Query: 2710 TYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINEGPA 2889
YL + Q +KLT+E+VNLA+ L F FY+F+DLL+LT+ LLAI++
Sbjct: 828 EYLRDVVCQRFPFSDK-EKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCVHV 886
Query: 2890 TEQVPSHRAMV-------NAIRN-------MSKSMMRGGNKENSKDLAKTPSVTAEEAGR 3027
T P + N +R+ M++ ++RGG +A P ++A
Sbjct: 887 TTIFPISKMAKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEGNVKQAEP 946
Query: 3028 TKEGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFP-------------CDED 3168
KE + + TKL + EILQF+++VR DYRI+ L FK F ++
Sbjct: 947 EKED-IMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQTSETSSGNSSQE 1005
Query: 3169 GSLMHSASINERMASELYDAIYRSSGHE--LHLDGRDGQLLLAILLQMTMSDYPPLTSIA 3342
G +++ E + I+ S L LD G+ L +LL +TM DYPPL S A
Sbjct: 1006 GPSNVPGALDFEHIEEQAEGIFGGSEENTPLDLDDHGGRTFLRVLLHLTMHDYPPLVSGA 1065
Query: 3343 LKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHH 3522
L++ FRHF+Q QE+L+ KQVQLLV++ DV+NY+QI +DL L+++ EKSELWV+ +
Sbjct: 1066 LQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQGP 1125
Query: 3523 SIDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRL 3702
+ +D EH + P+ +S S
Sbjct: 1126 D---ETMDGASGENEHKKTEEGNNKPQKHESTSSYN------------------------ 1158
Query: 3703 LIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDP--KPDTMNQQLLKNM 3876
Y +++++L+RL+ +C ++ K Q+LL+NM
Sbjct: 1159 ------------------------YRVVKEILIRLSKLCVQESASVRKSRKQQQRLLRNM 1194
Query: 3877 RVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEG 4056
+ VVLE + +P++K D M +++ L+HEFL++FC N++NQ+ L+K I+ + G
Sbjct: 1195 GAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHINLFLNP--G 1252
Query: 4057 MLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYD 4236
+L T++ IF NN +L S + E ++ H V IE + RN +++ LQ +V
Sbjct: 1253 ILEAVTMQH------IFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAEG 1306
Query: 4237 KEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIE 4416
K I+ Q+ V E+ + ++V Y D ASF+ L MM+ E++ D L YHI
Sbjct: 1307 KFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERDRM----DENSPLMYHIH 1362
Query: 4417 LVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAE 4596
LV LLA+CT GKN TE+KC S +P+D IVRVVT + C+ EVK Y+ L HCY+DT+ E
Sbjct: 1363 LVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCYVDTEVE 1422
Query: 4597 MKDAYKTEYVDHILNNLLEDI-RSLRVEKLTGAETATLEHYICHTVTEVLIKFFEAPYSA 4773
MK+ Y + ++ + N L DI R+ + LE Y+ V ++ FF +P+S
Sbjct: 1423 MKEIYTSNHMWKLFENFLVDICRACNNTSDRKHADSILEKYVTEIVMSIVTTFFSSPFS- 1481
Query: 4774 LQQAKVDVHHHKKTFSEVLLEL--TYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNI 4947
+ + F ++L + Y + K+S V CI+ L+ A+ I
Sbjct: 1482 --DQSTTLQTRQPVFVQLLQGVFRVYHCNWLMPSQKAS-----VESCIRVLSDVAKSRAI 1534
Query: 4948 TLPATLAGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHT 5127
+P L + V + ++ S + + RL+ +N L + +
Sbjct: 1535 AIPVDL-------DSQVNNLFLKSHSIVQKTAMNWRLSARNAARRDSVLAASRDYR---- 1583
Query: 5128 SANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKL 5307
N++ ++ + L PL AE SVLV+VLH PELLFPE + R +C GG + KL
Sbjct: 1584 --NIIERLQDIVSALEDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKCESGGFICKL 1641
Query: 5308 IQHCKTLMQNKQDNLCARVLQTLCKMCDCTKXXXXXXXXXXXXXXXXRYFGHHNNHHPPL 5487
I+H K L++ ++ LC +VLQTL +M + RY+G+ P
Sbjct: 1642 IKHTKQLLEENEEKLCIKVLQTLREMMTKDRGYGEKGEALRQVLVN-RYYGNVR----PS 1696
Query: 5488 DRQQSXXXXXXXXXXX------------XXXXTWSQ-ERDLYAIQCKLNDAGASDLVTDI 5628
R++S + S+ E L +QC L+ GAS+LV D+
Sbjct: 1697 GRRESLTSFGNGPLSAGGPGKPGGGGGGSGSSSMSRGEMSLAEVQCHLDKEGASNLVIDL 1756
Query: 5629 IIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRL 5808
I+ S +F ++I LA ALL GN +QHSF+ R+ + E FFK R++ AQ +
Sbjct: 1757 IMNASSDRVFHESILLAIALLEGGNTTIQHSFFCRLTEDKKSEKFFKVFYDRMKVAQQEI 1816
Query: 5809 KSDM-MSCSDSKPK-----VSLSATVSRRSSTVLTPLIDAGDTGFNGALFEVPQQVRHPS 5970
K+ + ++ SD K V A +++ T + + L E R
Sbjct: 1817 KATVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPTTQITEE----VRDQLLEASAATRKAF 1872
Query: 5971 ISEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPE--VALVEPILRVLQLLCENHNSLLQN 6144
+ + D H P +K+ D L + +++PILR LQLLCENHN LQN
Sbjct: 1873 TTFRREADPD-DHYQPGEGTQATADKAKDDLEMSAVITIMQPILRFLQLLCENHNRDLQN 1931
Query: 6145 FLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFG-EIGEHNFSLITQTLATLTEFCQG 6321
FLR Q+++TN+NLV ETL FLD +CGST G LG+ G I E N +LI QTL +LTE+CQG
Sbjct: 1932 FLRCQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINEKNVALINQTLESLTEYCQG 1991
Query: 6322 PCHENQNTMAMQE-NGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIMESRHDG 6498
PCHENQN +A E NG++II +L+LN +I K + ++E
Sbjct: 1992 PCHENQNCIATHESNGIDIITALILN--------------DINPLGKKRMDLVLE----- 2032
Query: 6499 ENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLKKKSGPQ 6678
L+N A+ K L+ ++ ++ N+ + ++L ++ KK+ Q
Sbjct: 2033 ------LKNNAS-----KLLLAIMESRHDSENAERILYNMRPKELV-----EVIKKAYMQ 2076
Query: 6679 ITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNIYILAHQLA 6858
V +D N +D + PR VGHNIYILAHQLA
Sbjct: 2077 GEVE--------------------------FEDGENGED-GAASPRNVGHNIYILAHQLA 2109
Query: 6859 IHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPINDICSYLTK 7038
H+ EL+ L + D EAL +Y + TAQIEIVR DRT+E++VFP+ IC +LTK
Sbjct: 2110 RHNKELQSMLKPGGQVDGD---EALEFYAKHTAQIEIVRLDRTMEQIVFPVPSICEFLTK 2166
Query: 7039 DTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPLWTRLSF 7218
++K +Y TERD QGSK+ +FF E +++EM WQ+KL+ + L WCA + W+ +SF
Sbjct: 2167 ESKLRIYYTTERDEQGSKINDFFLRSEDLFNEMNWQKKLRAQPVLYWCARNMSFWSSISF 2226
Query: 7219 HFAFIVNALVARYYPLPEHSNSSIS---LGNLYSWFAVFSSFLLAHYLRHDKIYLHKTXX 7389
+ A ++N LVA +YP ++ G L++ + + ++A H
Sbjct: 2227 NLAVLMNLLVAFFYPFKGVRGGTLEPHWSGLLWTAMLISLAIVIALPKPHG-------IR 2279
Query: 7390 XXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRNLHY 7569
+G+ TL++ G + NKI+ +++FV N G R ++ Y
Sbjct: 2280 ALIASTILRLIFSVGLQPTLFLLGAFNVCNKIIFLMSFVGNCGTFTRGYRAMVLDVEFLY 2339
Query: 7570 LLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALILLYF 7749
L+YL IC +GL VH Y +LLFD+++ EETL NVI SVTRN +SI+ T +LALIL+Y
Sbjct: 2340 HLLYLVICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYL 2399
Query: 7750 FSILGFLYFRHDFYLEVDPVENDSS------ATISSGIPSETC---PSEGCPGLQPSXX- 7899
FSI+G+L+F+ DF LEVD + N+++ + S + S+ C E C P
Sbjct: 2400 FSIVGYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDVCRVESGENCSSPAPREEL 2459
Query: 7900 --XXXXXXXXXXSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTXX 8073
+CETL MCI+ GLR+GGG+GDVLR P+ E +F RV YD+
Sbjct: 2460 VPAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVIYDLLFF 2519
Query: 8074 XXXXXXXXXXXXXXXXDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRET 8253
DTF DLR+EK +KE+ILK CFICGL+R +FDN++VTFE H +
Sbjct: 2520 FMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVTFEEHIKE 2579
Query: 8254 EHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSE 8433
EHN+WHYL +IV++++KD TE+TGPESYVA+ +K+RNLDWFPRM+A+SL S+ + +Q+E
Sbjct: 2580 EHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFPRMRAMSLVSSDSEGEQNE 2639
Query: 8434 VKQMKDQLLQMMTLMREIISQNEESRAFMEQ 8526
++ ++++L M L+ + Q E + M +
Sbjct: 2640 LRNLQEKLESTMKLVTNLSGQLSELKDQMTE 2670
>gi|46107962|gb|AAB04947.2| inositol 1,4,5-trisphosphate receptor type
1 [Homo sapiens]
Length = 2710
Score = 1654 bits (4284), Expect = 0.0
Identities = 1067/2910 (36%), Positives = 1571/2910 (53%), Gaps = 104/2910 (3%)
Frame = +1
Query: 109 LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
LHIGDI SLY E S+N GF+STLGLVDDRC+V+ + G +PPKKFRDCLFK+CP+N
Sbjct: 9 LHIGDICSLYAEGSTN----GFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKLCPMN 64
Query: 289 RYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQ 468
RY+AQK W K +S D L+NKL AAD E+++NE+E +K LG VIQYG+++Q
Sbjct: 65 RYSAQKQFWKAAK--PGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQ 122
Query: 469 LLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKI 648
LLH+KSNKY+TV K PA E+NAM+V LD AGNEGSWF I+P YK +IGD+V G+K+
Sbjct: 123 LLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGDKV 182
Query: 649 SLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSV 828
L P AG LH SS L+D+ EVN +N T W++ +F+ + +N+ + +
Sbjct: 183 VLNP-----VNAGQ---PLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDIL 234
Query: 829 KSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTN 1008
K GDVVRLFHA+Q+ FLT D K+ VFLR T R SA ATSS+ALWEV+VVQ +
Sbjct: 235 KGGDVVRLFHAEQEKFLTCDEHRKKQH----VFLRTTGRQSATSATSSKALWEVEVVQHD 290
Query: 1009 AYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRRASLIYSKTNNPMAMYSDGP 1188
RGG WN +RFKHLAT YL+AE V P L + + +P D
Sbjct: 291 PCRGGAGYWNSLFRFKHLATGHYLAAE-----VDPDFE--EECLEFQPSVDPD---QDAS 340
Query: 1189 NGVTNESTDTTQQNIPSVWVLGPTKSEFPE-EDANLLFQLDPSTFMKSNKEVPRRSYVRL 1365
+ + ++ SV PE D + +F+LDP+T + VPR SYVRL
Sbjct: 341 RSRLRNAQEKMVYSLVSV----------PEGNDISSIFELDPTTLRGGDSLVPRNSYVRL 390
Query: 1366 LHQSSDKWVHATNATEKQNLHYSSKNEKG-WVKVICEKNRVDKETFALLPVNPDEVRDLD 1542
H ++ WVH+TN + + EK +K+ + DKE FA++PV+P EVRDLD
Sbjct: 391 RHLCTNTWVHSTN------IPIDKEEEKPVMLKIGTSPVKEDKEAFAIVPVSPAEVRDLD 444
Query: 1543 FANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPS 1722
FANDA K L + ++ G + E S T+LL D + FVT ++ D L++ P+
Sbjct: 445 FANDASKVLGSIAGKLEKGTITQNER-RSVTKLLEDLVYFVTGGTNSGQDVLEVVFSKPN 503
Query: 1723 RDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIFKTMFQLCYC 1902
R+RQKL+REQ +L Q+F LL+APF T D R+ F+ + +LCY
Sbjct: 504 RERQKLMREQNILKQIFKLLQAPF-----TDCGDGPMLRLEELGDQRHAPFRHICRLCYR 558
Query: 1903 LLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERF 2082
+L++SQ YRKNQE++A++FG +Q+QIG+D++AEDT+TA+LHNN KLLEK++ ++ F
Sbjct: 559 VLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKHITAAEIDTF 618
Query: 2083 VELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKII------- 2241
V LVR NR+ +FLDYL+DLCV ++ QELIC +VL+ + DI ++TK++
Sbjct: 619 VSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETKLVLSRFEFE 678
Query: 2242 ---------------DGEIEVGWAPNFRKLV-----DIAEGAKSNS-DDAEHLDYYRHQL 2358
+ E+ + W + +++ ++A+ AK +D + L YYR+QL
Sbjct: 679 GVSSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDAKEGQKEDRDVLSYYRYQL 738
Query: 2359 DLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLHLH 2538
+L ++MC ++QYLAI+ IS QL +L+L+CMSD LPYDLR SF RLMLH+H
Sbjct: 739 NLFARMCLDRQYLAIN--------EISGQLDVDLILRCMSDENLPYDLRASFCRLMLHMH 790
Query: 2539 VVRG--SPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATVET 2712
V R ++ +++ARLW IP + + Y+S S S+ I E A + + VE
Sbjct: 791 VDRDPQEQVTPVKYARLWSEIPSEIAIDDYDS------SGASKDEIKERFA-QTMEFVEE 843
Query: 2713 YLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINEGPAT 2892
YL + Q +KLT+E+VNLA+ L F FY+F+DLL+LT+ LLAI++ T
Sbjct: 844 YLRDVVCQRFPFSDK-EKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCVHVT 902
Query: 2893 EQVPSHRAMV-------NAIRN-------MSKSMMRGGNKENSKDLAKTPSVTAEEAGRT 3030
P + N +R+ M++ ++RGG +A P ++A
Sbjct: 903 TIFPISKMAKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEGNVKQAEPE 962
Query: 3031 KEGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFP-------------CDEDG 3171
KE + + TKL + EILQF+++VR DYRI+ L FK F ++G
Sbjct: 963 KED-IMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQTSETSSGNSSQEG 1021
Query: 3172 SLMHSASINERMASELYDAIYRSSGHE--LHLDGRDGQLLLAILLQMTMSDYPPLTSIAL 3345
+++ E + I+ S L LD G+ L +LL +TM DYPPL S AL
Sbjct: 1022 PSNVPGALDFEHIEEQAEGIFGGSEENTPLDLDDHGGRTFLRVLLHLTMHDYPPLVSGAL 1081
Query: 3346 KVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHS 3525
++ FRHF+Q QE+L+ KQVQLLV++ DV+NY+QI +DL L+++ EKSELWV+ +
Sbjct: 1082 QLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQGPD 1141
Query: 3526 IDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLL 3705
+ +D EH + P+ +S S
Sbjct: 1142 ---ETMDGASGENEHKKTEEGNNKPQKHESTSSYN------------------------- 1173
Query: 3706 IKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDP--KPDTMNQQLLKNMR 3879
Y +++++L+RL+ +C ++ K Q+LL+NM
Sbjct: 1174 -----------------------YRVVKEILIRLSKLCVQESASVRKSRKQQQRLLRNMG 1210
Query: 3880 VYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGM 4059
+ VVLE + +P++K D M +++ L+HEFL++FC N++NQ+ L+K I+ + G+
Sbjct: 1211 AHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHINLFLNP--GI 1268
Query: 4060 LRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDK 4239
L T++ IF NN +L S + E ++ H V IE + RN +++ LQ +V K
Sbjct: 1269 LEAVTMQH------IFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAEGK 1322
Query: 4240 EIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIEL 4419
I+ Q+ V E+ + ++V Y D ASF+ L MM+ E++ D L YHI L
Sbjct: 1323 FIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERDRM----DENSPLMYHIHL 1378
Query: 4420 VRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEM 4599
V LLA+CT GKN TE+KC S +P+D IVRVVT + C+ EVK Y+ L HCY+DT+ EM
Sbjct: 1379 VELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCYVDTEVEM 1438
Query: 4600 KDAYKTEYVDHILNNLLEDI-RSLRVEKLTGAETATLEHYICHTVTEVLIKFFEAPYSAL 4776
K+ Y + ++ + N L DI R+ + LE Y+ V ++ FF +P+S
Sbjct: 1439 KEIYTSNHMWKLFENFLVDICRACNNTXDRKHADSILEKYVTEIVMSIVTTFFSSPFS-- 1496
Query: 4777 QQAKVDVHHHKKTFSEVLLEL--TYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNIT 4950
+ + F ++L + Y + K+S V CI+ L+ A+ I
Sbjct: 1497 -DQSTTLQTRQPVFVQLLQGVFRVYHCNWLMPSQKAS-----VESCIRVLSDVAKSRAIA 1550
Query: 4951 LPATLAGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHTS 5130
+P L + V + ++ S + + RL+ +N L + +
Sbjct: 1551 IPVDL-------DSQVNNLFLKSHSIVQKTAMNWRLSARNAARRDSVLAASRDYR----- 1598
Query: 5131 ANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLI 5310
N++ ++ + L PL AE SVLV+VLH PELLFPE + R +C GG + KLI
Sbjct: 1599 -NIIERLQDIVSALEDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKCESGGFICKLI 1657
Query: 5311 QHCKTLMQNKQDNLCARVLQTLCKMCDCTKXXXXXXXXXXXXXXXXRYFGHHNNHHPPLD 5490
+H K L++ ++ LC +VLQTL +M + RY+G+ P
Sbjct: 1658 KHTKQLLEENEEKLCIKVLQTLREMMTKDRGYGEKGEALRQVLVN-RYYGNVR----PSG 1712
Query: 5491 RQQSXXXXXXXXXXX------------XXXXTWSQ-ERDLYAIQCKLNDAGASDLVTDII 5631
R++S + S+ E L +QC L+ GAS+LV D+I
Sbjct: 1713 RRESLTSFGNGPLSAGGPGKPGGGGGGSGSSSMSRGEMSLAEVQCHLDKEGASNLVIDLI 1772
Query: 5632 IMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRLK 5811
+ S +F ++I LA ALL GN +QHSF+ R+ + E FFK R++ AQ +K
Sbjct: 1773 MNASSDRVFHESILLAIALLEGGNTTIQHSFFCRLTEDKKSEKFFKVFYDRMKVAQQEIK 1832
Query: 5812 SDM-MSCSDSKPK-----VSLSATVSRRSSTVLTPLIDAGDTGFNGALFEVPQQVRHPSI 5973
+ + ++ SD K V A +++ T + + L E R
Sbjct: 1833 ATVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPTTQITEE----VRDQLLEASAATRKAFT 1888
Query: 5974 SEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPE--VALVEPILRVLQLLCENHNSLLQNF 6147
+ + D H P +K+ D L + +++PILR LQLLCENHN LQNF
Sbjct: 1889 TFRREADPD-DHYQPGEGTQATADKAKDDLEMSAVITIMQPILRFLQLLCENHNRDLQNF 1947
Query: 6148 LRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFG-EIGEHNFSLITQTLATLTEFCQGP 6324
LR Q+++TN+NLV ETL FLD +CGST G LG+ G I E N +LI QTL +LTE+CQGP
Sbjct: 1948 LRCQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINEKNVALINQTLESLTEYCQGP 2007
Query: 6325 CHENQNTMAMQE-NGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIMESRHDGE 6501
CHENQN +A E NG++II +L+LN +I K + ++E
Sbjct: 2008 CHENQNCIATHESNGIDIITALILN--------------DINPLGKKRMDLVLE------ 2047
Query: 6502 NANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLKKKSGPQI 6681
L+N A+ K L+ ++ ++ N+ + ++L ++ KK+ Q
Sbjct: 2048 -----LKNNAS-----KLLLAIMESRHDSENAERILYNMRPKELV-----EVIKKAYMQG 2092
Query: 6682 TVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNIYILAHQLAI 6861
V +D N +D + PR VGHNIYILAHQLA
Sbjct: 2093 EVE--------------------------FEDGENGED-GAASPRNVGHNIYILAHQLAR 2125
Query: 6862 HDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPINDICSYLTKD 7041
H+ EL+ L + D EAL +Y + TAQIEIVR DRT+E++VFP+ IC +LTK+
Sbjct: 2126 HNKELQSMLKPGGQVDGD---EALEFYAKHTAQIEIVRLDRTMEQIVFPVPSICEFLTKE 2182
Query: 7042 TKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPLWTRLSFH 7221
+K +Y TERD QGSK+ +FF E +++EM WQ+KL+ + L WCA + W+ +SF+
Sbjct: 2183 SKLRIYYTTERDEQGSKINDFFLRSEDLFNEMNWQKKLRAQPVLYWCARNMSFWSSISFN 2242
Query: 7222 FAFIVNALVARYYPLPEHSNSSIS---LGNLYSWFAVFSSFLLAHYLRHDKIYLHKTXXX 7392
A ++N LVA YPL ++ G L++ + + ++A H
Sbjct: 2243 LAVLMNLLVAFLYPLKGVRGGTLEPHWSGLLWTAMLISLAIVIALPKPHG-------IRA 2295
Query: 7393 XXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRNLHYL 7572
+G+ TL++ G + NKI+ +++FV N G R ++ Y
Sbjct: 2296 LIASTILRLIFSVGLQPTLFLLGAFNVCNKIIFLMSFVGNCGTFTRGYRAMVLDVEFLYH 2355
Query: 7573 LVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALILLYFF 7752
L+YL IC +GL VH Y +LLFD+++ EETL NVI SVTRN +SI+ T +LALIL+Y F
Sbjct: 2356 LLYLVICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLF 2415
Query: 7753 SILGFLYFRHDFYLEVDPVENDSS------ATISSGIPSETC---PSEGCPGLQPSXX-- 7899
SI+G+L+F+ DF LEVD + N+++ + S + S+ C E C P
Sbjct: 2416 SIVGYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDVCRVESGENCSSPAPREELV 2475
Query: 7900 -XXXXXXXXXXSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTXXX 8076
+CETL MCI+ GLR+GGG+GDVLR P+ E +F RV YD+
Sbjct: 2476 PAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVIYDLLFFF 2535
Query: 8077 XXXXXXXXXXXXXXXDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETE 8256
DTF DLR+EK +KE+ILK CFICGL+R +FDN++VTFE H + E
Sbjct: 2536 MVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERXKFDNKTVTFEEHIKEE 2595
Query: 8257 HNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEV 8436
HN+WHYL +IV++++KD TE+TGPESYVA+ +K+RNLDWFPRM+A+SL S+ + +Q+E+
Sbjct: 2596 HNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFPRMRAMSLVSSDSEGEQNEL 2655
Query: 8437 KQMKDQLLQMMTLMREIISQNEESRAFMEQ 8526
+ ++++L M L+ + Q E + M +
Sbjct: 2656 RNLQEKLESTMKLVTNLSGQLSELKDQMTE 2685
>gi|1362832|pir||A55713 inositol 1,4,5-triphosphate receptor type 1 -
human
Length = 2713
Score = 1640 bits (4246), Expect = 0.0
Identities = 1061/2913 (36%), Positives = 1568/2913 (53%), Gaps = 107/2913 (3%)
Frame = +1
Query: 109 LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
LHIGDI SLY E S+N GF+STLGLVDDRC+V+ + G +PPKKFRDCLFK+CP+N
Sbjct: 9 LHIGDICSLYAEGSTN----GFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKLCPMN 64
Query: 289 RYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQ 468
RY+AQK W K +S D L+NKL AAD E+++NE+E +K LG VIQYG+++Q
Sbjct: 65 RYSAQKQFWKAAK--PGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQ 122
Query: 469 LLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKI 648
LLH+KSNKY+TV K PA E+NAM+V LD AGNEGSWF I+P YK +IGD+V G+K+
Sbjct: 123 LLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGDKV 182
Query: 649 SLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSV 828
L P AG LH SS L+D+ EVN +N T W++ +F+ + +N+ + +
Sbjct: 183 VLNP-----VNAGQ---PLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDIL 234
Query: 829 KSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTN 1008
K GDVVRLFHA+Q+ FLT D K+ VFLR T R SA ATSS+ALWEV+VVQ +
Sbjct: 235 KGGDVVRLFHAEQEKFLTCDEHRKKQH----VFLRTTGRQSATSATSSKALWEVEVVQHD 290
Query: 1009 AYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRRASLIYSKTNNPMAMYSDGP 1188
RGG WN +RFKHLAT YL+AE V P L + + +P D
Sbjct: 291 PCRGGAGYWNSLFRFKHLATGHYLAAE-----VDPDFE--EECLEFQPSVDPD---QDAS 340
Query: 1189 NGVTNESTDTTQQNIPSVWVLGPTKSEFPE-EDANLLFQLDPSTFMKSNKEVPRRSYVRL 1365
+ + ++ SV PE D + +F+LDP+T + VPR SYVRL
Sbjct: 341 RSRLRNAQEKMVYSLVSV----------PEGNDISSIFELDPTTLRGGDSLVPRNSYVRL 390
Query: 1366 LHQSSDKWVHATNATEKQNLHYSSKNEKG-WVKVICEKNRVDKETFALLPVNPDEVRDLD 1542
H ++ WVH+TN + + EK +K+ + DKE F ++PV+P EVRDLD
Sbjct: 391 RHLCTNTWVHSTN------IPIDKEEEKPVMLKIGTSPVKEDKEAFGIVPVSPAEVRDLD 444
Query: 1543 FANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPS 1722
FANDA K L + ++ G + E S T+LL D + FVT ++ D L++ P+
Sbjct: 445 FANDASKVLGSIAGKLEKGTITQNER-RSVTKLLEDLVYFVTGGTNSGQDVLEVVFSKPN 503
Query: 1723 RDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIFKTMFQLCYC 1902
R+RQKL+REQ +L Q+F LL+APF T D R+ F+ + +LCY
Sbjct: 504 RERQKLMREQNILKQIFKLLQAPF-----TDCGDGPMLRLEELGDQRHAPFRHICRLCYR 558
Query: 1903 LLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERF 2082
+L++SQ YRKNQE++A++FG +Q+QIG+D++AEDT+TA+LHNN KLLEK++ ++ F
Sbjct: 559 VLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKHITAAEIDTF 618
Query: 2083 VELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKII------- 2241
V LVR NR+ +FLDYL+DLCV ++ QELIC +VL+ + DI ++TK++
Sbjct: 619 VSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETKLVLSRFEFE 678
Query: 2242 ---------------DGEIEVGWAPNFRKLV-----DIAEGAKSNS-DDAEHLDYYRHQL 2358
+ E+ + W + +++ ++A+ AK +D + L YYR+QL
Sbjct: 679 GVSSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDAKEGQKEDRDVLSYYRYQL 738
Query: 2359 DLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLHLH 2538
+L ++MC ++QYLAI+ IS QL +L+L+CMSD LPYDLR SF RLMLH+H
Sbjct: 739 NLFARMCLDRQYLAIN--------EISGQLDVDLILRCMSDENLPYDLRASFCRLMLHMH 790
Query: 2539 VVRG--SPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATVET 2712
V R ++ +++ARLW IP + + Y+S S S+ I E A + + VE
Sbjct: 791 VDRDPQEQVTPVKYARLWSEIPSEIAIDDYDS------SGASKDEIKERFA-QTMEFVEE 843
Query: 2713 YLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINEGPAT 2892
YL + Q +KLT+E+VNLA+ L F FY+F+DLL+LT+ LLAI++ T
Sbjct: 844 YLRDVVCQRFPFSDK-EKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCVHVT 902
Query: 2893 EQVPSHRAMV-------NAIRN-------MSKSMMRGGNKENSKDLAKTPSVTAEEAGRT 3030
P + N +R+ M++ ++RGG +A P ++A
Sbjct: 903 TIFPISKMAKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEGNVKQAEPE 962
Query: 3031 KEGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVF--------------PCDED 3168
KE + + TKL + EILQF+++VR DYRI+ L FK F ++
Sbjct: 963 KED-IMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFWMKAIPRTSETSSGNSSQE 1021
Query: 3169 GSLMHSASINERMASELYDAIYRSSGHE--LHLDGRDGQLLLAILLQMTMSDYPPLTSIA 3342
G +++ E + I+ S L LD G+ L +LL +TM DYPPL S A
Sbjct: 1022 GPSNVPGALDFEHIEEQAEGIFGGSEENTPLDLDDHGGRTFLRVLLHLTMHDYPPLVSGA 1081
Query: 3343 LKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHH 3522
L++ FRHF+Q QE+L+ KQVQLLV++ DV+NY+QI +DL L+++ EKSELWV+ +
Sbjct: 1082 LQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQGP 1141
Query: 3523 SIDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRL 3702
+ +D EH + P+ +S S
Sbjct: 1142 D---ETMDGASGENEHKKTEEGNNKPQKHESTSSYN------------------------ 1174
Query: 3703 LIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDP--KPDTMNQQLLKNM 3876
Y +++++L+RL+ +C ++ K Q+LL+NM
Sbjct: 1175 ------------------------YRVVKEILIRLSKLCVQESASVRKSRKQQQRLLRNM 1210
Query: 3877 RVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEG 4056
+ VVLE + +P++K D M +++ L+HEFL++FC N++NQ+ L+K I+ + G
Sbjct: 1211 GAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHINLFLNP--G 1268
Query: 4057 MLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYD 4236
+L T++ IF NN +L S + E ++ H V IE + RN +++ LQ +V
Sbjct: 1269 ILEAVTMQH------IFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAEG 1322
Query: 4237 KEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIE 4416
K I+ Q+ V E+ + ++V Y D ASF+ L MM+ E++ D L YHI
Sbjct: 1323 KFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERDRM----DENSPLMYHIH 1378
Query: 4417 LVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAE 4596
LV LLA+CT GKN TE+KC S +P+D IVRVVT + C+ EVK Y+ L HCY+DT+ E
Sbjct: 1379 LVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCYVDTEVE 1438
Query: 4597 MKDAYKTEYVDHILNNLLEDI-RSLRVEKLTGAETATLEHYICHTVTEVLIKFFEAPYSA 4773
MK+ Y + ++ ++ N L DI R+ + LE Y+ V ++ FF +P+S
Sbjct: 1439 MKEIYTSNHMWKLVENFLVDICRACNNTSDRKHADSILEKYVTEIVMSIVTTFFSSPFS- 1497
Query: 4774 LQQAKVDVHHHKKTFSEVLLEL--TYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNI 4947
+ + F ++L + Y + K+S V CI+ L+ A+ I
Sbjct: 1498 --DQSTTLQTRQPVFVQLLQGVFRVYHCNWLMPSQKAS-----VESCIRVLSDVAKSRAI 1550
Query: 4948 TLPATLAGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHT 5127
+P L + V + ++ S + + RL+ +N L + +
Sbjct: 1551 AIPVDL-------DSQVNNLFLKSHSIVQKTAMNWRLSARNAARRDSVLAASRDYR---- 1599
Query: 5128 SANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKL 5307
N++ ++ + L PL AE SVLV+VLH PELLFPE + R +C GG + KL
Sbjct: 1600 --NIIERLQDIVSALEDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKCESGGFICKL 1657
Query: 5308 IQHCKTLMQNKQDNLCARVLQTLCKMCDCTKXXXXXXXXXXXXXXXXRYFGHHNNHHPPL 5487
I+H K L++ ++ LC +VLQTL +M + RY+G+ P
Sbjct: 1658 IKHTKQLLEENEEKLCIKVLQTLREMMTKDRGYGEKGEALRQVLVN-RYYGNVR----PS 1712
Query: 5488 DRQQSXXXXXXXXXXX------------XXXXTWSQ-ERDLYAIQCKLNDAGASDLVTDI 5628
R++S + S+ E L +QC L+ GAS+LV D+
Sbjct: 1713 GRRESLTSFGNGPLSAGGPGKPGGGGGGSGSSSMSRGEMSLAEVQCHLDKEGASNLVIDL 1772
Query: 5629 IIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRL 5808
I+ S +F ++I LA ALL GN +QHSF+ R+ + E FFK R++ AQ +
Sbjct: 1773 IMNVSSDRVFHESILLAIALLEGGNTTIQHSFFCRLTEDKKSEKFFKVFYDRMKVAQQEI 1832
Query: 5809 KSDM-MSCSDSKPK-----VSLSATVSRRSSTVLTPLIDAGDTGFNGALFEVPQQVRHPS 5970
K+ + ++ SD K V A +++ T + + L E R
Sbjct: 1833 KATVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPTTQITEE----VRDQLLEASAATRKAF 1888
Query: 5971 ISEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPE--VALVEPILRVLQLLCENHNSLLQN 6144
+ + D H P +K+ D L + +++PILR LQLLCENHN LQN
Sbjct: 1889 TTFRREADPD-DHYQPGEGTQATADKAKDDLEMSAVITIMQPILRFLQLLCENHNRDLQN 1947
Query: 6145 FLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFG-EIGEHNFSLITQTLATLTEFCQG 6321
FLR Q+++TN+NLV ETL FLD +CGST G LG+ G I E N +LI QTL +LTE+CQG
Sbjct: 1948 FLRCQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINEKNVALINQTLESLTEYCQG 2007
Query: 6322 PCHENQNTMAMQE-NGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIMESRHDG 6498
PCHENQN +A E NG++II +L+LN +I K + ++E
Sbjct: 2008 PCHENQNCIATHESNGIDIITALILN--------------DINPLGKKRMDLVLE----- 2048
Query: 6499 ENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLKKKSGPQ 6678
L+N A+ K L+ ++ ++ N+ + ++L ++ KK+ Q
Sbjct: 2049 ------LKNNAS-----KLLLAIMESRHDSENAERILYNMRPKELV-----EVIKKAYMQ 2092
Query: 6679 ITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNIYILAHQLA 6858
V +D N +D + PR VGHNIYILAHQLA
Sbjct: 2093 GEVE--------------------------FEDGENGED-GAASPRNVGHNIYILAHQLA 2125
Query: 6859 IHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPINDICSYLTK 7038
H+ EL+ L + D EAL +Y + TAQIEIVR DRT+E++VFP+ IC +LTK
Sbjct: 2126 RHNKELQSMLKPGGQVDGD---EALEFYAKHTAQIEIVRLDRTMEQIVFPVPSICEFLTK 2182
Query: 7039 DTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPLWTRLSF 7218
++K +Y TERD QGSK+ +FF E +++EM WQ+KL+ + L WCA + W+ +SF
Sbjct: 2183 ESKLRIYYTTERDEQGSKINDFFLRSEDLFNEMNWQKKLRAQPVLYWCARNMSFWSSISF 2242
Query: 7219 HFAFIVNALVARYYPLPEHSNSSIS---LGNLYSWFAVFSSFLLAHYLRHDKIYLHKTXX 7389
+ A ++N LVA YPL ++ G L++ + ++ H
Sbjct: 2243 NLAVLMNLLVAFLYPLKGVRGGTLEPHWSGLLWTGMLISLGIVIGLPNPHG-------IR 2295
Query: 7390 XXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRNLHY 7569
+G L++ G + KI+ +++FV N G R ++ ++ +
Sbjct: 2296 ALIGSTILRLIFSVGSQPALFLLGAFNVCKKIIFLMSFVGNCGTFTRGYRAMVLVLDVEF 2355
Query: 7570 L--LVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALILL 7743
L L+YL IC +GL VH Y +LL D+++ EE+L NVI SVTRN +SI+ T +LALIL+
Sbjct: 2356 LYHLLYLVICAMGLFVHVFFYSLLLLDLVYREESLLNVIKSVTRNGRSIILTAVLALILV 2415
Query: 7744 YFFSILGFLYFRHDFYLEVDPVENDSS------ATISSGIPSETC---PSEGCPGLQPSX 7896
Y FSI+G+L+F+ DF LEVD + N+++ + S + S+ C E C P
Sbjct: 2416 YLFSIVGYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDVCRVESGENCSSPAPRE 2475
Query: 7897 X---XXXXXXXXXXSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMT 8067
+CETL MCI+ GLR+GGG+GDVLR P+ E +F RV YD+
Sbjct: 2476 ELVPAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVIYDLL 2535
Query: 8068 XXXXXXXXXXXXXXXXXXDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHR 8247
DTF DLR+EK +KE+ILK CFICGL+R +FDN++VTFE H
Sbjct: 2536 FFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVTFEEHI 2595
Query: 8248 ETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQ 8427
+ EHN+WHYL +IV++++KD TE+TGPESYVA+ +K+RNLDWFPRM+A+SL S+ + +Q
Sbjct: 2596 KEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFPRMRAMSLVSSDSEGEQ 2655
Query: 8428 SEVKQMKDQLLQMMTLMREIISQNEESRAFMEQ 8526
+E++ ++++L M L+ + Q E + M +
Sbjct: 2656 NELRNLQEKLESTMKLVTNLSGQLSELKDQMTE 2688
>gi|7522013|pir||T31431 inositol 1,4,5-trisphosphate receptor,
localized in plasma membrane - Panulirus argus
gi|3660667|gb|AAC61691.1| inositol 1,4,5-trisphosphate receptor
[Panulirus argus]
Length = 2783
Score = 1638 bits (4241), Expect = 0.0
Identities = 1069/2964 (36%), Positives = 1567/2964 (52%), Gaps = 151/2964 (5%)
Frame = +1
Query: 94 GNNGNLHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFK 273
G+ LH+GDI+SLY E S + GF+STLGLVD RC+V + G +PPKKFRDCLF
Sbjct: 5 GSASFLHMGDIVSLYAEGSVS----GFISTLGLVDARCVVNPEAGDLSTPPKKFRDCLFS 60
Query: 274 VCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQY 453
+CP NRY+AQK W K +G+S D L+N+L AA E+ +NE+E +K +G VI Y
Sbjct: 61 ICPSNRYSAQKQFWKAAKH--SGNSTTDPSLLNRLHDAAKTEKRQNEAESKKLMGTVINY 118
Query: 454 GSMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVS 633
G +QLLH+KSNKY+TV K PA E+NAM+VYLD GNEGSWF I P YK GDNV
Sbjct: 119 GITIQLLHLKSNKYLTVNKRLPALLEKNAMRVYLDANGNEGSWFYINPYYKLRNPGDNVV 178
Query: 634 AGNKISLIPNSVSTTQAGHVKSQLHLSS-FNLLDHQSAAEVNCLNEPTEWQVFMFLLFDE 810
G+K+ L P AG QLH+SS +L DH EVN LN T W++ +FL E
Sbjct: 179 VGDKVILSP-----VNAGQ---QLHVSSTHDLRDHPGCKEVNVLNSNTCWKISLFLEHKE 230
Query: 811 NQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEV 990
N + +K GDV+RLFHA+Q+ FLT+D K+ VFLR T R +A ATSS+ALWEV
Sbjct: 231 NLEGVLKGGDVIRLFHAEQEKFLTMDEYKKKQH----VFLRTTGRTTATAATSSKALWEV 286
Query: 991 QVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAE----PSQVQVKPAMNGRRASLIYSKTN 1158
+VVQ + RGG WN +RFKHLAT YL+AE P+ + + +Y +
Sbjct: 287 EVVQHDPSRGGAGHWNSLFRFKHLATGHYLAAEIDDDPTPDPTRTKLRDPNGGPVYQLVS 346
Query: 1159 NPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKE 1338
P++ D +F+L+P+T ++ +
Sbjct: 347 VPLS------------------------------------NDIASIFELEPTTLIRGDSM 370
Query: 1339 VPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWVKVICEKNRVDKETFALLPVN 1518
VP+ SYVRL H + WVH+T+ + +++ KV C + DKE F+L+PV+
Sbjct: 371 VPQSSYVRLRHLCTSTWVHSTSIPIDKE-----EDKPVMSKVGCAPIKEDKEAFSLVPVH 425
Query: 1519 PDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVT------NSSD 1680
EVRDLDFA+DA + L K ++ G + E S LL+D + F N S+
Sbjct: 426 AKEVRDLDFAHDASEVLAKHAKKLEKGSITQAER-RSLMLLLLDLLYFTAEKEHEQNKSE 484
Query: 1681 HLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDS 1860
LA L++++ P+RDRQKLLREQ +L Q+F +L+APF QG D
Sbjct: 485 SLALALEVTN--PNRDRQKLLREQSILKQIFKILRAPFTETQG---GDGPLLRIDELNDP 539
Query: 1861 RNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPK 2040
R+ +K +F+LCY LL+ +Q YRKNQE +A+ FG +Q+QIG D++AE+T+TA+LHNN K
Sbjct: 540 RHSAYKNIFRLCYRLLRLAQQGYRKNQEHIAQHFGFMQKQIGIDILAEETITALLHNNRK 599
Query: 2041 LLEKYVKTPHVERFVELVRNNRQG---KFLDYLADLCVCRGEANKKIQELICTSVLSSKH 2211
LLE ++ +E FV LVR N +FLDYL LC+ +A + QELIC SV S K+
Sbjct: 600 LLEIHITATEIETFVGLVRKNMHKWDWRFLDYLKVLCISNNQAIPRTQELICKSVFSEKN 659
Query: 2212 RDIFMDTKIIDGEIEV-----GWAPNF------------------RKLVDIAEGAKSNSD 2322
+DI ++T++++ +IEV G P + +V++A A++ SD
Sbjct: 660 KDILIETRLVEEDIEVEVNVEGSCPMLAIERDEEVVLTWNNGECSKSIVELASRAQNLSD 719
Query: 2323 -----DAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNR 2487
D L+YYRH LDL S MC ++QYLAI P +S L L+L+CM +
Sbjct: 720 SDGGEDRLILEYYRHMLDLFSNMCLDRQYLAIRP--------LSPLLKINLMLKCMEEET 771
Query: 2488 LPYDLRGSFTRLMLHLHV--VRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSR 2661
L YDLR +F RLMLH+HV ++ +++ARLW I +++++ Y+ + ++ +
Sbjct: 772 LAYDLRAAFCRLMLHMHVDCEPQEMVTPVKYARLWSEIQPHMSIADYDKHAAMHSTEAAE 831
Query: 2662 MRIGEGIAHKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDL 2841
+ V+ VE YL + ++ M +KLT+E+V LA+ L F FYSFNDL
Sbjct: 832 TTFKD-----VIVFVEEYLCNVVDK-MWSFSDCEQNKLTFEVVKLARYLIYFGFYSFNDL 885
Query: 2842 LQLTQNLLAIINEGPATEQ------VPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTP- 3000
L+LT+ LL+I++ T+ +P A +A + KS+ G + L T
Sbjct: 886 LRLTKTLLSILDYSFDTDSKYFSNSIPQGTA--SAKGGVIKSLGDMGAVVTNLALGTTRM 943
Query: 3001 -------SVTAEEAGRTKEGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFPC 3159
S ++ G T++ L + TKL + EIL+F+++VR DYRI+ LS FK
Sbjct: 944 GPRLGGGSSPKKKVGATEKEDTLVMDTKLKIIEILEFILNVRLDYRISCLLSIFKK--ES 1001
Query: 3160 DEDGSLMHSASINERM-----------ASELYD----------------AIYRSSGHE-- 3252
DE+ S + I++ + A ++D ++ SS E
Sbjct: 1002 DENPSSLTGEGISQGLKNKNVENIWAQAQSIFDETSGLGLVWSSSQRKPSLQTSSCEENS 1061
Query: 3253 -LHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNND 3429
L LDG G+ L +LL +TM +YPPL S +L++ FRHF+Q QE+L++ KQVQLLV + D
Sbjct: 1062 SLDLDGEGGKKFLRVLLHLTMHEYPPLVSRSLQLLFRHFSQRQEVLQNFKQVQLLVQDGD 1121
Query: 3430 VENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPRAF 3609
VE+Y+QI D L+NL EKSELWV+ R D +K++ + D D L P+
Sbjct: 1122 VESYKQIKEDSDDLRNLVEKSELWVYKSRSTDEDGGGTKKKKKKNKDDDEDDALSKPKKP 1181
Query: 3610 DSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIA--YPL 3783
+ L D+ ++A+ L P A Y
Sbjct: 1182 PAPK---------------------------LTAQDKQESAIDLGLGPPLEPEQADNYKR 1214
Query: 3784 IRQMLVRLTGMCYRK---GDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLI 3954
I+Q+LVR+ +C + G+ P Q+LL+NM ++ VVLE + +P+D+K D M +LI
Sbjct: 1215 IQQILVRMNKLCVTQSSHGNLSPKRNEQRLLRNMGIHSVVLELLQIPYDRKEDKRMNELI 1274
Query: 3955 TLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASN 4134
L+H+FL++FC ++ NQ+ LYK S + G+L +T+ A+F++N L S
Sbjct: 1275 ELAHQFLQNFCLGDRANQALLYK--SIDLFLNPGLLEAKTV------CAVFKDNSHLCSE 1326
Query: 4135 VPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYV 4314
V E +I H + IE + R+ +L+ LQ +V + + Q+ V E+ A ++V Y
Sbjct: 1327 VSERVIQHFIHCIETHGRHVQYLKFLQTIVKAEGQFLRRSQDIVMQELVNAGEDVLVFYN 1386
Query: 4315 DNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPM 4494
+ ASF MMK ++ D L+YHIELV+LLA CT GKN +TE+KC S +P+
Sbjct: 1387 ERASFNMFIEMMKADRNRM--DFDDSSPLRYHIELVKLLACCTEGKNASTEIKCHSLLPL 1444
Query: 4495 DHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNN--LLEDIRSL 4668
D IV +V K C+ EVK Y+ L HCYIDT+ EMK+ Y + ++ + L++ R
Sbjct: 1445 DDIVAMVEHKDCIPEVKEAYINFLNHCYIDTEVEMKEIYNSHHIWSLFEKSFLVDMGRVA 1504
Query: 4669 RVEKLTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYL 4848
LE+Y+ +++ ++ FF +P+S Q + + F + LL Y
Sbjct: 1505 TAPPDRRHADKALENYVINSLMTIITTFFNSPFSDQSQT---IQTRQPVFVQ-LLHAVYR 1560
Query: 4849 EKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASS 5028
+ G + V CIK LT+ A +HNI++P L +S S R ++
Sbjct: 1561 VSQAVMGHQR----VNVENCIKTLTEVARKHNISIPVDLEAQVVS--MSQRTTSIMTRTA 1614
Query: 5029 AKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVV-TCYHMMIGEFKFYLHPLHAAE 5205
+KW N R +S+S++ V+ ++ ++ + L PL AAE
Sbjct: 1615 SKW------------SNRATRRDASSSSLSGRMDHLVIEQDFNSVVSVLEAELRPLVAAE 1662
Query: 5206 GSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKM 5385
SVLV++L+ P LF S +C GG +++LI+HC+ L++ + + LC +VL+TL M
Sbjct: 1663 LSVLVDILYQPHRLFRPDSEASIKCKNGGFISRLIRHCEKLLEEEDEKLCIQVLKTLKDM 1722
Query: 5386 CDCTKXXXXXXXXXXXXXXXXRYFGHHNNHHPPLDRQQSXXXXXXXXXXXXXXXTWSQE- 5562
T RYF + P ++++ +
Sbjct: 1723 --ITDSEYGEKGDALRNLLLTRYFDQY-----PWSKKEAAELRARQPQNVGPGDVVQRRS 1775
Query: 5563 -RDLYAIQCKLNDAGASDLVTDIIIMEPSR-EIFLKAIHLARALLHEGNDKVQHSFYMRM 5736
+ L +QC L GA++LV D+++ +R IF++A+ L A L GN +Q Y ++
Sbjct: 1776 GKSLSEVQCDLAKKGAANLVVDLVMKSQNRHRIFVEAVELGIAPLEGGNRDIQDMLYTKL 1835
Query: 5737 KQKDIHEPFFKAILTRIQTAQNRLK-------SDMMS-CSDSKPKVSLSATVSRR----- 5877
++ D + FFK +++ AQ ++ SD+ + SD K ++R+
Sbjct: 1836 QESDTSQNFFKVFDNKMEEAQQEIRNTVTVNTSDLSAKSSDEKDGPKEGEKLNRKKGGHK 1895
Query: 5878 -SSTVLTPLIDAGDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKST 6054
+ V+ I + + +R S + + L +++ ++ +
Sbjct: 1896 PNGLVMNDEIREELSVAASVTSQAYTNIRAGSTGDDNNSCLGL-NTLEEVGENYGGRSNK 1954
Query: 6055 DA------LPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTV 6216
DA L P++ ++EP+LR LQLLCENHN LQ FLR Q +TN+NLVS+TL FLD +
Sbjct: 1955 DANADNPKLSPKITVMEPVLRFLQLLCENHNLYLQIFLRNQKSKTNYNLVSKTLMFLDCI 2014
Query: 6217 CGSTKGSLGVFG-EIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQE-NGLNIIISLV 6390
CGST G LG+ G I EHN SLI QTL TLTE+CQGPCHENQN +A E NGL+II +L+
Sbjct: 2015 CGSTTGGLGLLGLYINEHNVSLINQTLETLTEYCQGPCHENQNCIATHESNGLHIITALI 2074
Query: 6391 LNEIKPLADDHMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAI 6570
L++I PLA M+L LE+K+ ASKLLLAIMESR D ENA R+L++M I
Sbjct: 2075 LSDINPLAKARMDLVLELKNNASKLLLAIMESRADSENAERILQSM------------HI 2122
Query: 6571 KQAYEMTNSNHHMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTE 6750
Q ++ + +H + F D
Sbjct: 2123 DQLLDVVCNLYHQESMDDDEFFEDGSSD-------------------------------- 2150
Query: 6751 KNISSSLDDKFNDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREA 6930
DD V P+EVGHNIYIL HQLA H LE L S +K +A
Sbjct: 2151 -------DD--------GVSPKEVGHNIYILCHQLAKHHKGLEELLSKSGNEK---LSKA 2192
Query: 6931 LNYYKERTAQIEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFD 7110
L +Y+E TAQIEIVR DRT+E++VFPI +IC+YLTK+TK VYN ERD QG+KVT+FF+
Sbjct: 2193 LTHYRENTAQIEIVRSDRTMEQIVFPIPEICNYLTKETKQRVYNTAERDEQGTKVTDFFE 2252
Query: 7111 EWETMYHEMIWQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEH-SNSS 7287
+ M+ EM WQ+KL+ + LS + + LW+RL F A +VN +VA +YP H N S
Sbjct: 2253 KCNDMFIEMQWQKKLKSQAVLSTISNYMSLWSRLLFLLALMVNLIVALFYPYTSHLPNIS 2312
Query: 7288 ISLGNLYSWFAVFSSFLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGIL 7467
L L + ++ + + IYL +G TL++ G
Sbjct: 2313 GHLNGLLWVVLLIGLAIVVSFQQQIFIYL------LGSISVVRLIFSVGPEPTLWLLGSA 2366
Query: 7468 QLVNKIVHVVAFVSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDI 7647
++ K +H+V+ + NKG + + + + L Y ++YL C+LGL VHP Y +LLFD+
Sbjct: 2367 NVLIKGIHLVSLMGNKGTFAKRLEQQVTDGELLYHVIYLVFCVLGLSVHPFCYSVLLFDV 2426
Query: 7648 IFTEETLQNVIASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEV-------DP 7806
++ EETL NVI SVTRN SI+ T LALIL+Y FSI+G+++FR+DF ++V D
Sbjct: 2427 VYREETLLNVIRSVTRNGWSIILTAALALILVYMFSIIGYMFFRNDFIVDVTDNDIDWDT 2486
Query: 7807 VENDSSATISSGIPSE----------------TCPSEGCPGLQ------PSXXXXXXXXX 7920
++ + I S + + C E L
Sbjct: 2487 IQKHINQRIESYVTTSLSVKKNSVEDTCEMGVDCTEEDSSNLYNVVDSITKEVMVEVEDA 2546
Query: 7921 XXXSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTXXXXXXXXXXX 8100
+C TL MCI+ + GLR+GGGIGD+LR P+ E++F RV YD+
Sbjct: 2547 KEEACSTLLMCIVTSLNHGLRSGGGIGDILRAPSNKENLFAARVIYDLLFFFVVIIIVLN 2606
Query: 8101 XXXXXXXDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLY 8280
DTF DLR+EK E+ILKN+CFICGL RS FDN++V FE H + EHN+WHYLY
Sbjct: 2607 LIFGVIIDTFADLRSEKQNSEEILKNSCFICGLTRSSFDNKAVNFEDHIKREHNMWHYLY 2666
Query: 8281 YIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLL 8460
+ V + +KD TEFTGPESYV VK+++L+WFPRM+A+SL E + + +EV+ + +L
Sbjct: 2667 FYVQVNVKDPTEFTGPESYVYLLVKEKDLNWFPRMRAMSLSIGETEGEMNEVRCLNAKLD 2726
Query: 8461 QMMTLMREIISQNEESRAFMEQFQ 8532
+ L+ ++ Q E + M + Q
Sbjct: 2727 RTQALVDSLVYQLTELKDEMTKQQ 2750
>gi|4504793|ref|NP_002214.1| inositol 1,4,5-triphosphate receptor,
type 2 [Homo sapiens]
gi|2833252|sp|Q14571|IP3S_HUMAN Inositol 1,4,5-trisphosphate receptor
type 2 (Type 2 inositol 1,4,5-trisphosphate receptor)
(Type 2 InsP3 receptor) (IP3 receptor isoform 2)
(InsP3R2)
gi|450469|dbj|BAA05384.1| type 2 inositol 1,4,5-trisphosphate
receptor [Homo sapiens]
Length = 2701
Score = 1623 bits (4203), Expect = 0.0
Identities = 1046/2892 (36%), Positives = 1552/2892 (53%), Gaps = 86/2892 (2%)
Frame = +1
Query: 109 LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
L+IGDI+SLY E S N GF+STLGLVDDRC+V + G +PPKKFRDCLFKVCP+N
Sbjct: 9 LYIGDIVSLYAEGSVN----GFISTLGLVDDRCVVHPEAGDLANPPKKFRDCLFKVCPMN 64
Query: 289 RYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQ 468
RY+AQK W ++ Q + + L+ KL+ AA+ E+++NESE +K LG +++Y +++Q
Sbjct: 65 RYSAQKQYWKAKQAKQGNHT--EAALLKKLQHAAELEQKQNESENKKLLGEIVKYSNVIQ 122
Query: 469 LLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKI 648
LLH+KSNKY+TV K PA E+NAM+V LD AGNEGSWF I P +K + GDN+ G+K+
Sbjct: 123 LLHIKSNKYLTVNKRLPALLEKNAMRVSLDAAGNEGSWFYIHPFWKLRSEGDNIVVGDKV 182
Query: 649 SLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSV 828
L+P AG LH S+ LLD+ EVN +N T W++ +F+ + +++ +
Sbjct: 183 VLMP-----VNAGQ---PLHASNIELLDNPGCKEVNAVNCNTSWKITLFMKYSSYREDVL 234
Query: 829 KSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTN 1008
K GDVVRLFHA+Q+ FLT D K+ +FLR T R SA ATSS+ALWE++VV +
Sbjct: 235 KGGDVVRLFHAEQEKFLTCDEYEKKQH----IFLRTTLRQSATSATSSKALWEIEVVHHD 290
Query: 1009 AYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRRASLIYSKTNNPMAMYSDGP 1188
RGG +WN +RFKHLAT YL+AE + P Y N DG
Sbjct: 291 PCRGGAGQWNSLFRFKHLATGNYLAAE-----LNPD---------YRDAQNEGKNVRDGV 336
Query: 1189 NGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLL 1368
+ + ++ ++ S D LF+LD +T +++ VPR SYVRL
Sbjct: 337 PPTSKKKRQAGEK------IMYTLVSVPHGNDIASLFELDATTLQRADCLVPRNSYVRLR 390
Query: 1369 HQSSDKWVHATNATEKQNLHYSSKNEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFA 1548
H ++ WV +T+ + + +K+ + + DKE FA++ V EVRDLDFA
Sbjct: 391 HLCTNTWVTSTSIPID-----TDEERPVMLKIGTCQTKEDKEAFAIVSVPLSEVRDLDFA 445
Query: 1549 NDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRD 1728
NDA K L +K ++ G + E T+LL D I FV + ++ + L + P+R+
Sbjct: 446 NDANKVLATTVKKLENGTITQNER-RFVTKLLEDLIFFVADVPNNGQEVLDVVITKPNRE 504
Query: 1729 RQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIFKTMFQLCYCLL 1908
RQKL+REQ +L QVF +LKAPF + G D R +K M +LCY +L
Sbjct: 505 RQKLMREQNILAQVFGILKAPFKEKAGE----GSMLRLEDLGDQRYAPYKYMLRLCYRVL 560
Query: 1909 KYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVE 2088
++SQ YRKNQE++A+ F +Q QIG+D++AEDT+T +LHNN KLLEK++ +E FV
Sbjct: 561 RHSQQDYRKNQEYIAKNFCVMQSQIGYDILAEDTITPLLHNNRKLLEKHITAKEIETFVS 620
Query: 2089 LVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKII--------- 2241
L+R NR+ +FLDYL+DLCV A QELIC +LS + DI + TK++
Sbjct: 621 LLRRNREPRFLDYLSDLCVSNTTAIPVTQELICKFMLSPGNADILIQTKVVSMQADNPME 680
Query: 2242 ---------DGEIEVGWA-----PNFRKLVDIAEGAKSNSD-DAEHLDYYRHQLDLLSQM 2376
D E+ + W P+ + + +A+ AK + D E L YYR+QL+L ++M
Sbjct: 681 SSILSDDIDDEEVWLYWIDSNKEPHGKAIRHLAQEAKEGTKADLEVLTYYRYQLNLFARM 740
Query: 2377 CQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLHLHVVRGSP 2556
C ++QYLAI+ IS QL +L+L+C+SD LP+DLR SF RLMLH+HV R
Sbjct: 741 CLDRQYLAIN--------QISTQLSVDLILRCVSDESLPFDLRASFCRLMLHMHVDRDPQ 792
Query: 2557 MSAI--RHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATVETYLMGLR 2730
S + R+ARLW IP + + Y+S++ D SR + A + VE YL +
Sbjct: 793 ESVVPVRYARLWTEIPTKITIHEYDSIT-----DSSRNDMKRKFA-LTMEFVEEYLKEVV 846
Query: 2731 NQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIIN--EGPATEQVP 2904
NQ +KLT+E+V+LA+ L F FYSF++LL+LT+ LLAI++ + P +
Sbjct: 847 NQPFPFGDK-EKNKLTFEVVHLARNLIYFGFYSFSELLRLTRTLLAILDIVQAPMSSYFE 905
Query: 2905 SHRAMVNAIRNMSKSMMRGGNKENSKDLAK-----------TPSVTAEEAGRTKEGRALN 3051
+ N+ +++ G L++ PS+ + G E +
Sbjct: 906 RLSKFQDGGNNVMRTIHGVGEMMTQMVLSRGSIFPMSVPDVPPSIHPSKQGSPTEHEDVT 965
Query: 3052 VK-TKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGS----------LMHSA--- 3189
V TKL + EILQF++ VR DYRI+ LS +K F D D + L+ SA
Sbjct: 966 VMDTKLKIIEILQFILSVRLDYRISYMLSIYKKEFGEDNDNAETSASGSPDTLLPSAIVP 1025
Query: 3190 SINERMASELYDAIYRSSGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFT 3369
I+E A R + + LD G+ L +L+ + M DY PL S AL++ F+HF+
Sbjct: 1026 DIDEIAAQAETMFAGRKEKNPVQLDDEGGRTFLRVLIHLIMHDYAPLLSGALQLLFKHFS 1085
Query: 3370 QYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDE 3549
Q E+L+ KQVQLLVSN DV+NY+QI DL L+ EKSELWV ++ + + E+ E
Sbjct: 1086 QRAEVLQAFKQVQLLVSNQDVDNYKQIKADLDQLRLTVEKSELWV--EKSSNYENGEIGE 1143
Query: 3550 KE-RTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRND 3726
+ + E + + ++ SP ++D
Sbjct: 1144 SQVKGGEEPIEESNILSP-----------------------------------VQDGTKK 1168
Query: 3727 AAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFI 3906
+ D Y +++++L+RL+ +C + + K +Q+LLKNM + VVL+ +
Sbjct: 1169 PQI------DSNKSNKYRIVKEILIRLSKLCVQ--NKKCRNQHQRLLKNMGAHSVVLDLL 1220
Query: 3907 SVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEV 4086
+P++K +D M +++ L+H FL++FC+ N +NQ L+K ++ G+L ET+
Sbjct: 1221 QIPYEK-NDEKMNEVMNLAHTFLQNFCRGNPQNQVLLHKHLNLF--LTPGLLEAETMRH- 1276
Query: 4087 GTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKV 4266
IF NN L + + E ++ H V IE + R+ +L LQ +V K ++ Q+ V
Sbjct: 1277 -----IFMNNYHLCNEISERVVQHFVHCIETHGRHVEYLRFLQTIVKADGKYVKKCQDMV 1331
Query: 4267 ANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTR 4446
E+ ++V Y D ASF L MM E++ D L YHI LV LLA CT
Sbjct: 1332 MTELINGGEDVLIFYNDRASFPILLHMMCSERDR----GDESGPLAYHITLVELLAACTE 1387
Query: 4447 GKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYV 4626
GKN TE+KC S +P+D IVRVVT C+ EVK Y+ + HCY+DT+ EMK+ Y + ++
Sbjct: 1388 GKNVYTEIKCNSLLPLDDIVRVVTHDDCIPEVKIAYVNFVNHCYVDTEVEMKEIYTSNHI 1447
Query: 4627 DHILNNLLEDIRSLRVEKLTGAETAT--LEHYICHTVTEVLIKFFEAPYSALQQAKVDVH 4800
+ N L D+ + T + A LE + ++ ++ FF +P+S +
Sbjct: 1448 WKLFENFLVDMARV-CNTTTDRKHADIFLEKCVTESIMNIVSGFFNSPFS---DNSTSLQ 1503
Query: 4801 HHKKTFSEVLLELTYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQM 4980
H+ F ++L + + V CI+ L + A+ I +P L
Sbjct: 1504 THQPVFIQLLQSAFRIYNCTWPNPAQKAS---VESCIRTLAEVAKNRGIAIPVDL----- 1555
Query: 4981 SGQTSVRQKWQQAASS-AKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHM 5157
+ V + ++ S+ + +G RL+ ++ L G + N++
Sbjct: 1556 --DSQVNTLFMKSHSNMVQRAAMGWRLSARSGPRFKEALGGPAWDYR-----NIIEKLQD 1608
Query: 5158 MIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQN 5337
++ + P+ AE SVLV+VL++PELLFPEGS R +C G ++KLI H K LM+
Sbjct: 1609 VVASLEHQFSPMMQAEFSVLVDVLYSPELLFPEGSDARIRC--GAFMSKLINHTKKLME- 1665
Query: 5338 KQDNLCARVLQTLCKMCDCTKXXXXXXXXXXXXXXXXRYFGHHNNHHPPLDRQQSXXXXX 5517
K++ LC ++LQTL +M + K RYF ++ ++ S
Sbjct: 1666 KEEKLCIKILQTLREMLE-KKDSFVEEGNTLRKILLNRYF--KGDYSIGVNGHLSGAYSK 1722
Query: 5518 XXXXXXXXXXTWSQERDLYA--IQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALL 5691
S + + IQC L+ GAS+LV D+I+ + IF + I L ALL
Sbjct: 1723 TAQVGGSFSGQDSDKMGISMSDIQCLLDKEGASELVIDVIVNTKNDRIFSEGIFLGIALL 1782
Query: 5692 HEGNDKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRLKSDMM---------SCSDSKP 5844
GN + Q+SFY ++ ++ E FFK + R++ AQ ++S + D
Sbjct: 1783 EGGNTQTQYSFYQQLHEQKKSEKFFKVLYDRMKAAQKEIRSTVTVNTIDLGNKKRDDDNE 1842
Query: 5845 KVSLSATVSRRSSTVLTPLIDAGDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDL 6024
++ + R ST+ G G L E ++ ++
Sbjct: 1843 LMTSGPRMRVRDSTLHLK------EGMKGQLTEASSATSKAYCVYRREMDPEIDIMCTGP 1896
Query: 6025 APYQDEEKSTD--ALPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETL 6198
EEKS + + P +A+++PILR LQLLCENHN LQNFLR Q+++TN+NLV ETL
Sbjct: 1897 EAGNTEEKSAEEVTMSPAIAIMQPILRFLQLLCENHNRELQNFLRNQNNKTNYNLVCETL 1956
Query: 6199 SFLDTVCGSTKGSLGVFG-EIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQE-NGLN 6372
FLD +CGST G LG+ G I E N +L+ Q L +LTE+CQGPCHENQ +A E NG++
Sbjct: 1957 QFLDCICGSTTGGLGLLGLYINEKNVALVNQNLESLTEYCQGPCHENQTCIATHESNGID 2016
Query: 6373 IIISLVLNEIKPLADDHMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPK 6552
III+L+LN+I PL M+L L++K+ AS K
Sbjct: 2017 IIIALILNDINPLGKYRMDLVLQLKNNAS------------------------------K 2046
Query: 6553 QLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGI 6732
L+ ++ ++ N+ + R+L D+ K + Q G+
Sbjct: 2047 LLLAIMESRHDSENAERILFNMRPRELV-----DVMKNAYNQ----------------GL 2085
Query: 6733 VSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLD-GSDEKK 6909
H DD+ DD V P++VGHNIYILAHQLA H+ L+ L GSD +
Sbjct: 2086 ECDHG--------DDEGGDD---GVSPKDVGHNIYILAHQLARHNKLLQQMLKPGSDPDE 2134
Query: 6910 DDLTREALNYYKERTAQIEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGS 7089
D EAL YY TAQIEIVR DRT+E++VFP+ +IC YLT+++K V+N TERD QGS
Sbjct: 2135 GD---EALKYYANHTAQIEIVRHDRTMEQIVFPVPNICEYLTRESKCRVFNTTERDEQGS 2191
Query: 7090 KVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLP 7269
KV +FF + E +Y+EM WQ+K+++ L W + + LW +SF+ A +N VA +YP
Sbjct: 2192 KVNDFFQQTEDLYNEMKWQKKIRNNPALFWFSRHISLWGSISFNLAVFINLAVALFYPFG 2251
Query: 7270 EHSNSSISLGNLYS---WFAV-FSSFLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGV 7437
+ + +L L+S W AV + +L + + I IG+
Sbjct: 2252 DDGDEG-TLSPLFSVLLWIAVAICTSMLFFFSKPVGI------RPFLVSIMLRSIYTIGL 2304
Query: 7438 TLTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHP 7617
TL + G L NKIV +V+FV N+G R ++ Y + Y+ +C+LGL VH
Sbjct: 2305 GPTLILLGAANLCNKIVFLVSFVGNRGTFTRGYRAVILDMAFLYHVAYVLVCMLGLFVHE 2364
Query: 7618 MIYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLE 7797
Y LLFD+++ EETL NVI SVTRN +SI+ T +LALIL+Y FSI+GFL+ + DF +E
Sbjct: 2365 FFYSFLLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSIIGFLFLKDDFTME 2424
Query: 7798 VDPVENDSSATISSGIPS-------ETCPSEGCPGLQPSXXXXXXXXXXXX--SCETLWM 7950
VD ++N + T S +P+ E C E C P+ +C+TL M
Sbjct: 2425 VDRLKNRTPVTGSHQVPTMTLTTMMEACAKENCSPTIPASNTADEEYEDGIERTCDTLLM 2484
Query: 7951 CILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTXXXXXXXXXXXXXXXXXXDTF 8130
CI+ QGLRNGGG+GDVLR P+ E +F RV YD+ DTF
Sbjct: 2485 CIVTVLNQGLRNGGGVGDVLRRPSKDEPLFAARVVYDLLFYFIVIIIVLNLIFGVIIDTF 2544
Query: 8131 GDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLYYIVMLQIKDE 8310
DLR+EK +KE+ILK CFICGL+R +FDN++V+FE H ++EHN+WHYLY+IV++++KD
Sbjct: 2545 ADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKSEHNMWHYLYFIVLVKVKDP 2604
Query: 8311 TEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLLQMMTLMREII 8490
TE+TGPESYVAQ + ++NLDWFPRM+A+SL +E D++Q+E++ ++++L M+L++++
Sbjct: 2605 TEYTGPESYVAQMIVEKNLDWFPRMRAMSLVSNEGDSEQNEIRSLQEKLESTMSLVKQLS 2664
Query: 8491 SQNEESRAFMEQ 8526
Q E + M +
Sbjct: 2665 GQLAELKEQMTE 2676
>gi|27805961|ref|NP_776794.1| inositol 1,4,5-triphosphate receptor,
type 2 [Bos taurus]
gi|17432546|gb|AAL39077.1| inositol 1,4,5-trisphosphate receptor type
2 [Bos taurus]
Length = 2701
Score = 1623 bits (4202), Expect = 0.0
Identities = 1046/2885 (36%), Positives = 1547/2885 (53%), Gaps = 79/2885 (2%)
Frame = +1
Query: 109 LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
L+IGDI+SLY E S N GF++TLGLVDDRC+V + G +PPKKFRDCLFKVCP+N
Sbjct: 9 LYIGDIVSLYAEGSVN----GFINTLGLVDDRCVVHPEAGDLANPPKKFRDCLFKVCPMN 64
Query: 289 RYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQ 468
RY+AQK W ++ Q + + L+ KL+ AA+ E+++NESE +K LG +++Y +++Q
Sbjct: 65 RYSAQKQYWKAKQAKQGNHT--EAALLKKLQHAAELEQKQNESENKKLLGEIVKYSNVIQ 122
Query: 469 LLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKI 648
LLH+KSNKY+TV K PA E+NAM+V LD AGNEGSWF I P +K + GDN+ G K+
Sbjct: 123 LLHIKSNKYLTVNKRLPALLEKNAMRVSLDAAGNEGSWFYIHPFWKLRSEGDNIVVGGKV 182
Query: 649 SLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSV 828
L+P AG LH S+ LLD+ EVN +N T W++ +F+ + +++ +
Sbjct: 183 VLMP-----VNAGQ---PLHASNIELLDNPGCKEVNAVNCNTSWKITLFMKYSSYREDVL 234
Query: 829 KSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTN 1008
K GDVVRLFHA+Q+ FLT D K+ +FLR T R SA ATSS+ALWE++VV +
Sbjct: 235 KGGDVVRLFHAEQEKFLTCDEYEKKQH----IFLRTTLRQSATSATSSKALWEIEVVHHD 290
Query: 1009 AYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRRASLIYSKTNNPMAMYSDGP 1188
RGG +WN +RFKHLAT YL+AE + P Y N DG
Sbjct: 291 PCRGGAGQWNSLFRFKHLATGNYLAAE-----LNPD---------YRDAQNEGKNVRDGD 336
Query: 1189 NGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLL 1368
+ + ++ ++ S D LF+LD +T +++ VPR SYVRL
Sbjct: 337 LPASKKKRQAGEK------IMYTLVSVPHGNDIASLFELDATTLQRADCLVPRNSYVRLR 390
Query: 1369 HQSSDKWVHATNATEKQNLHYSSKNEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFA 1548
H ++ WV +T+ + + +K+ + + DKE FA++ V P EVRDLDFA
Sbjct: 391 HLCTNTWVTSTSIPID-----TDEERPVMLKIGTCQTKEDKEAFAIVSVPPSEVRDLDFA 445
Query: 1549 NDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRD 1728
NDA K L +K ++ G + E T+LL D I FV + ++ D L + P+R+
Sbjct: 446 NDANKVLATTVKKLENGTITQNER-RFVTKLLEDLIFFVADVPNNGQDVLDVLITKPNRE 504
Query: 1729 RQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIFKTMFQLCYCLL 1908
RQKL+REQ +L QVF +LKAPF + G D R +K M +LCY +L
Sbjct: 505 RQKLMREQNILAQVFGILKAPFKEKAGE----GSMLRLEDLGDQRYAPYKYMLRLCYRVL 560
Query: 1909 KYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVE 2088
+SQ YRKNQE++A+ F +Q QIG+D++AEDT+TA+LHNN KLLEK++ +E FV
Sbjct: 561 GHSQQDYRKNQEYIAKNFCVMQSQIGYDILAEDTITALLHNNRKLLEKHITAKEIETFVS 620
Query: 2089 LVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKII--------- 2241
L+R NR+ +FLDYL+DLCV A QELIC +LS + DI + TK++
Sbjct: 621 LLRRNREPRFLDYLSDLCVSNTTAIPVTQELICKFMLSPGNADILIQTKLVSMQGDNPME 680
Query: 2242 ---------DGEIEVGWA-----PNFRKLVDIAEGAKSNSD-DAEHLDYYRHQLDLLSQM 2376
+ E+ + W P+ + + +A+ AK + D E L YYR+QL+L ++M
Sbjct: 681 SAILSDDIDEEEVWLYWIDSNKEPHGKAIRHLAQEAKEGTKADLEVLTYYRYQLNLFARM 740
Query: 2377 CQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLHLHVVRGSP 2556
C ++QYLAI+ IS QL +L+L+CMSD LP+DLR SF RLMLH+HV R
Sbjct: 741 CLDRQYLAIN--------QISTQLSVDLILRCMSDESLPFDLRASFCRLMLHMHVDRDPQ 792
Query: 2557 MSAI--RHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATVETYLMGLR 2730
S + R+ARLW IP + + Y+S++ D SR + A + VE YL +
Sbjct: 793 ESVVPVRYARLWTEIPTKITIHEYDSIT-----DSSRNDMKRKFA-LTMEFVEEYLKEVV 846
Query: 2731 NQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIIN--EGPATEQVP 2904
NQ +KLT+E+V+LA+ L F FYSF++LL+LT+ LLAI++ + P +
Sbjct: 847 NQPFPFGDK-EKNKLTFEVVHLARNLIYFGFYSFSELLRLTRTLLAILDIVQAPMSSYFE 905
Query: 2905 SHRAMVNAIRNMSKSMMRGGNKENSKDLAK-----------TPSVTAEEAGRTKEGRALN 3051
+ N+ +++ G L++ PS+ + G + +
Sbjct: 906 RLSKFQDGGNNVMRTIHGVGEMMTQMVLSRGSIFPMSVPDIQPSLHPSKQGSPTDHEDVT 965
Query: 3052 VK-TKLIVAEILQFVMDVRRDYRITMALSWFKNVF-------PCDEDGS---LMHSA--- 3189
V TKL + EILQF++ VR DY I+ LS +K F +GS L+ SA
Sbjct: 966 VMDTKLKIIEILQFILSVRLDYGISYMLSIYKKEFGENNGNAEMSTNGSPDTLLPSAIVP 1025
Query: 3190 SINERMASELYDAIYRSSGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFT 3369
I+E A R + + LD G+ L +L+ + M DYPPL S AL++ F+HF+
Sbjct: 1026 DIDEIAAQAETMFAGRKEKNPVQLDDEGGRTFLRVLIHLIMHDYPPLLSGALQLLFKHFS 1085
Query: 3370 QYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDE 3549
Q E+L+ KQVQLLVSN DV+NY+QI DL L+ EKSELWV ++ S + E+ E
Sbjct: 1086 QRAEVLQAFKQVQLLVSNQDVDNYKQIKADLDQLRLTVEKSELWV--EKSSSYENGEMGE 1143
Query: 3550 KE-RTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRND 3726
+ + E + D ++ SP ++D
Sbjct: 1144 NQVKGGEEPIEDSNILSP-----------------------------------VQDGTKK 1168
Query: 3727 AAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFI 3906
+ + ++ Y +++++L+RL+ +C + + K +Q+LLKNM + VVL+ +
Sbjct: 1169 PQIDSNKSNN------YRIVKEILIRLSKLCVQ--NKKCRNQHQRLLKNMGAHSVVLDLL 1220
Query: 3907 SVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEV 4086
+P++K +D M +++ L+H FL++FC+ N +NQ L+K ++ G+L ET+
Sbjct: 1221 QIPYEK-NDEKMNEVMNLAHTFLQNFCRGNPQNQVLLHKHLNLF--LTPGLLEAETMRH- 1276
Query: 4087 GTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKV 4266
IF NN L + + E ++ H V IE + R+ +L LQ +V K ++ Q+ V
Sbjct: 1277 -----IFMNNYHLCNEISERVVQHFVHCIETHGRHVEYLRFLQTIVKADGKYVKKCQDMV 1331
Query: 4267 ANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTR 4446
E+ ++V Y D ASF L MM E++ D L YHI LV LLA CT
Sbjct: 1332 MTELINGGEDVLIFYNDRASFPILLHMMCSERDR----GDESGPLAYHITLVELLAACTE 1387
Query: 4447 GKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYV 4626
GKN TE+KC S +P+D IVRVVT C+ EVK Y+ + HCY+DT+ EMK+ Y + ++
Sbjct: 1388 GKNVYTEIKCNSLLPLDDIVRVVTHDDCIPEVKIAYVNFVNHCYVDTEVEMKEIYTSNHI 1447
Query: 4627 DHILNNLLEDIRSLRVEKLTGAETAT-LEHYICHTVTEVLIKFFEAPYSALQQAKVDVHH 4803
+ N L D+ + T LE + ++ ++ FF +P+S +
Sbjct: 1448 WKLFENFLVDMARVCNTTTDRKHADTFLEKCVTESIMNIVSGFFNSPFS---DNSTSLQT 1504
Query: 4804 HKKTFSEVLLELTYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMS 4983
H+ F ++L + + V CI+ L + A+ I +P L +
Sbjct: 1505 HQPVFIQLLQSAFRIYNCTWPNPAQKAS---VESCIRTLAEVAKNRGIAIPVDLDSQVNT 1561
Query: 4984 GQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMI 5163
Q A+ +G RL+ ++ L G S N++ ++
Sbjct: 1562 LFLKSHSNMVQRAA------MGWRLSARSGPRFKEALGGPSWDYR-----NIIEKLQDVV 1610
Query: 5164 GEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQ 5343
+ P+ AE SVLV+VL++PELLFPEGS R +C G ++KLI H K LM+ K+
Sbjct: 1611 ASLEQQFSPMMQAEFSVLVDVLYSPELLFPEGSDARIRC--GAFMSKLINHTKKLME-KE 1667
Query: 5344 DNLCARVLQTLCKMCDCTKXXXXXXXXXXXXXXXXRYFGHHNNHHPPLDRQQSXXXXXXX 5523
+ LC ++LQTL +M + K RYF ++ ++ S
Sbjct: 1668 EKLCIKILQTLREMLE-KKDSFVEEGNTLRKILLNRYF--KGDYGVSINGHLSGTYCKTA 1724
Query: 5524 XXXXXXXXTWSQERDLYA--IQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHE 5697
S + + IQC L+ GAS+LV D+I+ + IF + I L ALL
Sbjct: 1725 QVGGSFSGQDSDKMGISMSDIQCLLDKEGASELVIDVIVNTKNDRIFSEGILLGIALLEG 1784
Query: 5698 GNDKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRLKSDM----MSCSDSKPKVSLSAT 5865
GN + Q+SFY ++ ++ E FFK + R++ AQ ++S + + + K
Sbjct: 1785 GNTQTQYSFYQQLHEQKKSEKFFKVLYDRMKAAQKEIRSTVTVNTIDLGNKKRDDDTELM 1844
Query: 5866 VSRRSSTVLTPLIDAGDTGFNGALFEVPQQVRHPSISEMSQLSN--DLTHSIPDLAPYQD 6039
S V + + G G L E ++ D+ + P+ +D
Sbjct: 1845 TSGPRMRVRDSSLHLKE-GMKGQLTEASSATSKAYCVYRREMDPEIDIMCAGPEAGNAED 1903
Query: 6040 EEKSTDALPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVC 6219
+ P +A+++PI R LQLLCENHN LQ+FLR Q+++TN+NLV ETL FLD +C
Sbjct: 1904 RSTEEVTMSPAIAIMQPISRFLQLLCENHNRELQHFLRNQNNKTNYNLVCETLQFLDCIC 1963
Query: 6220 GSTKGSLGVFG-EIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQE-NGLNIIISLVL 6393
GST G LG+ G I E N L+ QTL +LTE+CQGPCHENQ +A E NG++III+L+L
Sbjct: 1964 GSTTGGLGLLGLYINEKNVVLVNQTLESLTEYCQGPCHENQTCIATHESNGIDIIIALIL 2023
Query: 6394 NEIKPLADDHMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIK 6573
N+I PL M+L L++K+ A PK L+ ++
Sbjct: 2024 NDINPLGKYRMDLVLQLKNNA------------------------------PKLLLAIME 2053
Query: 6574 QAYEMTNSNHHMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEK 6753
++ N+ + R+L D+ K + Q G+ H
Sbjct: 2054 SRHDSENAERILFNMRPRELV-----DVMKNAYNQ----------------GLECDHG-- 2090
Query: 6754 NISSSLDDKFNDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLD-GSDEKKDDLTREA 6930
DD+ DDD V P++VGHNIYILAHQLA H+ L+ L GSD D EA
Sbjct: 2091 ------DDEGGDDD---VSPKDVGHNIYILAHQLARHNKLLQQMLKPGSDPDDGD---EA 2138
Query: 6931 LNYYKERTAQIEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFD 7110
L YY TAQIEIVR DRT+E++VFP+ +IC YLT+++K V+N TERD QGSKV +FF
Sbjct: 2139 LKYYANHTAQIEIVRHDRTMEQIVFPVPNICEYLTRESKCRVFNTTERDEQGSKVNDFFQ 2198
Query: 7111 EWETMYHEMIWQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSI 7290
+ E +Y+EM WQ+K++ L W + + LW +SF+ A +N VA +YP + +
Sbjct: 2199 QTEDLYNEMKWQKKIRSNPALFWFSRHISLWGSISFNLAVFINLAVALFYPFGDDGDEG- 2257
Query: 7291 SLGNLYS---WFAV-FSSFLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIF 7458
+L ++S W AV + +L + + I IG+ TL +
Sbjct: 2258 TLSPMFSILLWIAVAICTSMLFFFSKPVGI------RPFLVSVMLRSIYTIGLGPTLILL 2311
Query: 7459 GILQLVNKIVHVVAFVSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILL 7638
G L NKIV +V+FV N+G R ++ Y + Y+ +C+LGL VH Y LL
Sbjct: 2312 GAANLCNKIVFLVSFVGNRGTFTRGYRAVILDMAFLYHVAYVLVCMLGLFVHEFFYSFLL 2371
Query: 7639 FDIIFTEETLQNVIASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVEND 7818
FD+++ EETL NVI SVTRN +SI+ T +LALIL+Y FSI+GFL+ + DF +EVD ++N
Sbjct: 2372 FDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSIIGFLFLKDDFTMEVDRLKNR 2431
Query: 7819 SSATISSGIPS-------ETCPSEGCPGLQPSXXXXXXXXXXXX--SCETLWMCILQTGY 7971
+ T S+ +P+ TC + C P+ +C+TL MCI+
Sbjct: 2432 TPITGSNAVPTMTLTSILSTCEKDNCSPTIPASNTADEEYEDGIERTCDTLLMCIVTVLN 2491
Query: 7972 QGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTXXXXXXXXXXXXXXXXXXDTFGDLRAEK 8151
QGLRNGGG+GDVLR P+ E +F RV YD+ DTF DLR+EK
Sbjct: 2492 QGLRNGGGVGDVLRRPSKDEPLFAARVVYDLLFYFIVIIIVLNLIFGVIIDTFADLRSEK 2551
Query: 8152 NEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPE 8331
+KE+ILK CFICGL+R +FDN++V+FE H ++EHN+WHYLY++V++++KD TE+TGPE
Sbjct: 2552 QKKEEILKTTCFICGLERDKFDNKTVSFEEHIKSEHNMWHYLYFLVLVKVKDPTEYTGPE 2611
Query: 8332 SYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLLQMMTLMREIISQNEESR 8511
SYVAQ + ++NLDWFPRM+A+SL SE D++Q+EV+ ++++L M+L++++ SQ E +
Sbjct: 2612 SYVAQMIVEKNLDWFPRMRAMSLVSSEGDSEQNEVRNLQEKLESTMSLVKQLSSQLAELK 2671
Query: 8512 AFMEQ 8526
M +
Sbjct: 2672 EQMTE 2676
>gi|13022060|gb|AAK11622.1| IP3 receptor isoform 2 [Rattus norvegicus]
gi|34851154|gb|AAQ82910.1| inositol trisphosphate receptor type 2
[Rattus norvegicus]
Length = 2701
Score = 1622 bits (4200), Expect = 0.0
Identities = 1059/2895 (36%), Positives = 1558/2895 (53%), Gaps = 89/2895 (3%)
Frame = +1
Query: 109 LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
L+IGDI+SLY E S N GF+STLGLVDDRC+V + G +PPKKFRDCLFKVCP+N
Sbjct: 9 LYIGDIVSLYAEGSVN----GFISTLGLVDDRCVVHPEAGDLTNPPKKFRDCLFKVCPMN 64
Query: 289 RYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQ 468
RY+AQK W ++ Q + + L+ KL+ AA+ E+++NESE +K LG +++Y +++Q
Sbjct: 65 RYSAQKQYWKAKQAKQGNHT--EAALLKKLQHAAELEQKQNESENRKLLGEIVKYSNVIQ 122
Query: 469 LLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKI 648
LLH+KSNKY+TV K PA E+NAM+V LD AGNEGSWF I P +K + GDN+ G+K+
Sbjct: 123 LLHIKSNKYLTVNKRLPALLEKNAMRVSLDAAGNEGSWFYIHPFWKLRSEGDNIVVGDKV 182
Query: 649 SLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSV 828
L+P AG LH S+ LLD+ EVN +N T W++ +F+ F +++ +
Sbjct: 183 VLMP-----VNAGQ---PLHASNVELLDNPGCKEVNAVNCNTSWKITLFMKFSSYREDVL 234
Query: 829 KSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTN 1008
K GDVVRLFHA+Q+ FLT D K+ +FLR T R SA ATSS+ALWE++VV +
Sbjct: 235 KGGDVVRLFHAEQEKFLTCDDYEKKQH----IFLRTTLRQSATSATSSKALWEIEVVHHD 290
Query: 1009 AYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRRASLIYSKTNNPMAMYSDGP 1188
RGG +WN +RFKHLAT YL+AE + P Y N DG
Sbjct: 291 PCRGGAGQWNSLFRFKHLATGNYLAAE-----LNPD---------YRDAQNEGKTVRDGE 336
Query: 1189 NGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLL 1368
+ + ++ ++ S D LF+LD +T +++ VPR SYVRL
Sbjct: 337 LPTSKKKRQAGEK------IMYTLVSVPHGNDIASLFELDATTLQRADCLVPRNSYVRLR 390
Query: 1369 HQSSDKWVHATNATEKQNLHYSSKNEKG-WVKVICEKNRVDKETFALLPVNPDEVRDLDF 1545
H ++ WV +T+ + ++ E+ +K+ + + DKE FA++ V EVRDLDF
Sbjct: 391 HLCTNTWVTSTS------IPIDTEEERPVMLKIGTCQTKEDKEAFAIVCVPLSEVRDLDF 444
Query: 1546 ANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPSR 1725
ANDA K L +K ++ G + E T+LL D I FV + +++ D L + P+R
Sbjct: 445 ANDANKVLATTVKKLENGSITQNER-RFVTKLLEDLIFFVADVTNNGQDVLDVVITKPNR 503
Query: 1726 DRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIFKTMFQLCYCL 1905
+RQKL+REQ +L QVF +LKAPF + G D R +K + +LCY +
Sbjct: 504 ERQKLMREQNILAQVFGILKAPFKEKAGE----GSMLRLEDLGDQRYAPYKYVLRLCYRV 559
Query: 1906 LKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFV 2085
L++SQ YRKNQE++A+ F +Q QIG+D++AEDT+TA+LHNN KLLEK++ +E FV
Sbjct: 560 LRHSQQDYRKNQEYIAKNFCVMQSQIGYDILAEDTITALLHNNRKLLEKHITAKEIETFV 619
Query: 2086 ELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKII-------- 2241
L+R NR+ +FLDYL+DLCV A QELIC +LS + DI + TK++
Sbjct: 620 SLLRRNREPRFLDYLSDLCVSNSTAIPVTQELICKFMLSPGNADILIQTKLVSMQVENPM 679
Query: 2242 ----------DGEIEVGWA-----PNFRKLVDIAEGAKSNSD-DAEHLDYYRHQLDLLSQ 2373
D E+ + W P+ + + +A+ A+ + D E L YYR+QL+L ++
Sbjct: 680 ESSILPDDIDDEEVWLYWIDSNKEPHGKAIRHLAQEAREGTKADLEVLTYYRYQLNLFAR 739
Query: 2374 MCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLHLHVVRGS 2553
MC ++QYLAI+ IS QL +L+L+C+SD LP+DLR SF RLMLH+HV R
Sbjct: 740 MCLDRQYLAIN--------QISTQLSVDLILRCVSDESLPFDLRASFCRLMLHMHVDRDP 791
Query: 2554 PMSAI--RHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATVETYLMGL 2727
S + R+ARLW IP + + Y+S++ D SR + A + VE YL +
Sbjct: 792 QESVVPVRYARLWTEIPTKITIHEYDSIT-----DSSRNDMKRKFA-LTMEFVEEYLKEV 845
Query: 2728 RNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIIN--EGPATEQV 2901
NQ +KLT+E+V+LA+ L F FYSF++LL+LT+ LLAI++ + P +
Sbjct: 846 VNQPFPFGDK-EKNKLTFEVVHLARNLIYFGFYSFSELLRLTRTLLAILDIVQAPMSSYF 904
Query: 2902 PSHRAMVNAIRNMSKSMMRGGNKENSKDLAK-----------TPSVTAEEAGRTKEGRAL 3048
+ N+ +++ G L++ PSV + E +
Sbjct: 905 ERLSKFQDGSNNVMRTIHGVGEMMTQMVLSRGSIFPVSVPDAQPSVHPSKQASPGEQEDV 964
Query: 3049 NVK-TKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSAS----------- 3192
V TKL V EILQF++ VR DYRI+ LS +K F + DG+ SAS
Sbjct: 965 TVMDTKLKVIEILQFILSVRLDYRISYMLSIYKKEFG-ENDGNGDPSASGTPETLLPSAL 1023
Query: 3193 ---INERMASELYDAIYRSSGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRH 3363
I+E A R + LD G+ L +L+ + M DY PL S AL++ F+H
Sbjct: 1024 VPDIDEIAAQAETMFAGRKEKTPVQLDDEGGRTFLRVLIHLIMHDYAPLLSGALQLLFKH 1083
Query: 3364 FTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEV 3543
F+Q E+L+ KQVQLLVSN DV+NY+QI DL L+ EKSELWV
Sbjct: 1084 FSQRAEVLQAFKQVQLLVSNQDVDNYKQIKADLDQLRLTVEKSELWV------------- 1130
Query: 3544 DEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRN 3723
+ ++++GD E E NE LL+ +
Sbjct: 1131 ----------------EKSGSYENGDMGEGQAKGGEE-----ANEESNLLSPV------Q 1163
Query: 3724 DAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEF 3903
D A Q S+K Y +++++L+RL+ +C + + K +Q+LLKNM + VVL+
Sbjct: 1164 DGAKTPQIDSNKGN--NYRIVKEILIRLSKLCVQ--NKKCRNQHQRLLKNMGAHSVVLDL 1219
Query: 3904 ISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEE 4083
+ +P++K D M +++ L+H FL++FC+ N +NQ L+K ++ G+L ET+
Sbjct: 1220 LQIPYEKT-DEKMNEVMDLAHTFLQNFCRGNPQNQVLLHKHLNLF--LTPGLLEAETMRH 1276
Query: 4084 VGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEK 4263
IF NN L + + E ++ H V IE + R+ +L LQ +V K ++ Q+
Sbjct: 1277 ------IFMNNYHLCNEISERVVQHFVHCIETHGRHVEYLRFLQTIVKADGKYVKKCQDM 1330
Query: 4264 VANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCT 4443
V E+ ++V Y D ASF L MM E+ D L YHI LV LLA CT
Sbjct: 1331 VMTELINGGEDVLIFYNDRASFPILLNMMCSERAR----GDESGPLAYHITLVELLAACT 1386
Query: 4444 RGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEY 4623
GKN TE+KC S +P+D IVRVVT C+ EVK Y+ + HCY+DT+ EMK+ Y + +
Sbjct: 1387 EGKNVYTEIKCNSLLPLDDIVRVVTHDDCIPEVKIAYVNFVNHCYVDTEVEMKEIYTSNH 1446
Query: 4624 VDHILNNLLEDIRSLRVEKLTGAETAT-LEHYICHTVTEVLIKFFEAPYSALQQAKVDVH 4800
+ + N L D+ + T LE + +V ++ FF +P+S +
Sbjct: 1447 IWKLFENFLVDMARVCNTTTDRKHADTFLERCVTESVMNIVSGFFNSPFS---DNSTSLQ 1503
Query: 4801 HHKKTFSEVLLELTYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQM 4980
H+ F ++L + + V CI+ L + A+ I +P L
Sbjct: 1504 THQPVFIQLLQSAFRIYNCTWPNPAQKAS---VESCIRALAEVAKNRGIAIPVDLD---- 1556
Query: 4981 SGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMM 5160
S ++ K +S+ + +G RL+ ++ L G + N++ +
Sbjct: 1557 SQVNTLFMK--NHSSTVQRAAMGWRLSARSGPRFKEALGGPAWDYR-----NIIEKLQDV 1609
Query: 5161 IGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNK 5340
+ + P+ AE SVLV+VL++PELLFPEGS R +C G ++KLI H K LM+ K
Sbjct: 1610 VASLEQQFSPMMQAEFSVLVDVLYSPELLFPEGSDARIRC--GAFMSKLINHTKKLME-K 1666
Query: 5341 QDNLCARVLQTLCKMCDCTKXXXXXXXXXXXXXXXXRYF--GHHNNHHPPLDRQQSXXXX 5514
++ LC ++LQTL +M + K RYF H + PL +
Sbjct: 1667 EEKLCIKILQTLREMLE-KKDSFMEEGSTLRKILLNRYFKGDHSVGVNGPLSGAYAKTAQ 1725
Query: 5515 XXXXXXXXXXXTWSQERD-----LYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLA 5679
Q+ D + IQC L+ GAS+LV D+I+ + IF + I L
Sbjct: 1726 VGGGFT-------GQDADKTGISMSDIQCLLDKEGASELVIDVIVNTKNDRIFSEGILLG 1778
Query: 5680 RALLHEGNDKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRLKSDMMSCSDSKPKVSLS 5859
ALL GN + Q+SFY ++ ++ E FFK + R++ AQ ++S + + + L
Sbjct: 1779 IALLEGGNTQTQNSFYQQLHEQKKSEKFFKVLYDRMKAAQKEIRSTV-----TVNTIDLG 1833
Query: 5860 ATVSRRSSTVLT--PLIDAGDT------GFNGALFEVPQQVRHPSISEMSQLSNDLTHSI 6015
+ S ++ P + D+ G G L E ++ D+
Sbjct: 1834 SKKREEDSDLMALGPRMRVRDSSLHLKEGMKGQLTEASSATSKAYCVYRREMDPDIDTMC 1893
Query: 6016 PDLAPYQDEEKSTD--ALPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVS 6189
P EEKS + + P + ++ PILR LQLLCENHN LQNFLR Q+++TN+NLV
Sbjct: 1894 PGQEAGSAEEKSAEEVTMSPAITIMRPILRFLQLLCENHNRELQNFLRNQNNKTNYNLVC 1953
Query: 6190 ETLSFLDTVCGSTKGSLGVFG-EIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQE-N 6363
ETL FLD +CGST G LG+ G I E N +L+ QTL +LTE+CQGPCHENQ +A E N
Sbjct: 1954 ETLQFLDCICGSTTGGLGLLGLYINEKNVALVNQTLESLTEYCQGPCHENQTCIATHESN 2013
Query: 6364 GLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSG 6543
G++III+L+L++I PL M+L L+ L+N A+
Sbjct: 2014 GIDIIIALILSDINPLGKYRMDLVLQ-------------------------LKNNAS--- 2045
Query: 6544 GPKQLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDA 6723
K L+ ++ ++ N+ + ++L D+ K + Q
Sbjct: 2046 --KLLLAIMESRHDSENAERILFNMRPKELV-----DVMKNAYNQ--------------- 2083
Query: 6724 SGIVSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLD-GSD 6900
G+ H D++ DD V P++VGHNIYILAHQLA H+ L+ L GSD
Sbjct: 2084 -GLECNHG--------DEEGGDD---GVSPKDVGHNIYILAHQLARHNKLLQQMLKPGSD 2131
Query: 6901 EKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDN 7080
++ D EAL YY TAQIEIVR DRT+E++VFP+ +IC +LT+++K V+N TERD
Sbjct: 2132 PEEGD---EALKYYANHTAQIEIVRHDRTMEQIVFPVPNICEFLTRESKYRVFNTTERDE 2188
Query: 7081 QGSKVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYY 7260
QGSKV +FF + E +Y+EM WQ+K+++ L W + + LW +SF+ A +N VA +Y
Sbjct: 2189 QGSKVNDFFQQTEDLYNEMKWQKKIRNNPALFWFSRHISLWGSISFNLAVFINLAVALFY 2248
Query: 7261 PLPEHSNSSISLGNLYS---WFAV-FSSFLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXX 7428
P + + +L L+S W AV + +L + + I
Sbjct: 2249 PFGDDGDEG-TLSPLFSALLWVAVAICTSMLFFFSKPVGI------RPFLVSIMLRSIYT 2301
Query: 7429 IGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRNLHYLLVYLFICILGLL 7608
IG+ TL + G L NKIV +V+FV N+G R ++ Y + Y+ +C+LGL
Sbjct: 2302 IGLGPTLILLGAANLCNKIVFLVSFVGNRGTFTRGYRAVILDMAFLYHVAYVLVCMLGLF 2361
Query: 7609 VHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDF 7788
VH Y LLFD+++ EETL NVI SVTRN +SI+ T +LALIL+Y FSI+GFL+ + DF
Sbjct: 2362 VHEFFYSFLLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSIIGFLFLKDDF 2421
Query: 7789 YLEVDPVENDSSATISSGIPSET-------CPSEGCPGLQPSXXXXXXXXXXXX--SCET 7941
+EVD ++N + T + G+P+ T CP E C PS +C+T
Sbjct: 2422 TMEVDRLKNRTPVTGNDGVPTMTLTSMLGTCPKENCSPTIPSSNAAGEGGEDGIERTCDT 2481
Query: 7942 LWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTXXXXXXXXXXXXXXXXXX 8121
L MCI+ QGLRNGGG+GDVLR P+ E +F RV YD+
Sbjct: 2482 LLMCIVTVLNQGLRNGGGVGDVLRRPSKDEPLFAARVVYDLLFFFIVIIIVLNLIFGVII 2541
Query: 8122 DTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLYYIVMLQI 8301
DTF DLR+EK +KE+ILK CFICGL+R +FDN++V+FE H ++EHN+WHYLY+IV++++
Sbjct: 2542 DTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKSEHNMWHYLYFIVLVKV 2601
Query: 8302 KDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLLQMMTLMR 8481
KD TE+TGPESYVAQ + ++NLDWFPRM+A+SL +E D++Q+E++ ++++L M+L++
Sbjct: 2602 KDPTEYTGPESYVAQMITEKNLDWFPRMRAMSLVSNEGDSEQNEIRNLQEKLESTMSLVK 2661
Query: 8482 EIISQNEESRAFMEQ 8526
++ Q E + M +
Sbjct: 2662 QLSGQLAELKEQMTE 2676
>gi|13591975|ref|NP_112308.1| inositol 1,4,5-triphosphate receptor 2;
inositol 1,4,5-triphosphate receptor type 2; inositol
triphosphate receptor type 2; inositol 145-triphosphate
receptor 2; inositol 145-triphosphate receptor type 2
[Rattus norvegicus]
gi|266389|sp|P29995|IP3S_RAT Inositol 1,4,5-trisphosphate receptor
type 2 (Type 2 inositol 1,4,5-trisphosphate receptor)
(Type 2 InsP3 receptor) (IP3 receptor isoform 2)
(InsP3R2)
gi|111841|pir||S17796 inositol-trisphosphate receptor type 2 - rat
gi|56508|emb|CAA43852.1| inositol triphosphate receptor type 2
[Rattus norvegicus]
Length = 2701
Score = 1622 bits (4199), Expect = 0.0
Identities = 1061/2895 (36%), Positives = 1558/2895 (53%), Gaps = 89/2895 (3%)
Frame = +1
Query: 109 LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
L+IGDI+SLY E S N GF+STLGLVDDRC+V + G +PPKKFRDCLFKVCP+N
Sbjct: 9 LYIGDIVSLYAEGSVN----GFISTLGLVDDRCVVHPEAGDLTNPPKKFRDCLFKVCPMN 64
Query: 289 RYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQ 468
RY+AQK W ++ Q + + L+ KL+ AA+ E+++NESE +K LG +++Y ++Q
Sbjct: 65 RYSAQKQYWKAKQAKQGNHT--EAALLKKLQHAAELEQKQNESENRKLLGEIVKYSKVIQ 122
Query: 469 LLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKI 648
LLH+KSNKY+TV K PA E+NAM+V LD AGNEGSWF I P +K + GDN+ G+K+
Sbjct: 123 LLHIKSNKYLTVNKRLPALLEKNAMRVSLDAAGNEGSWFYIHPFWKLRSEGDNIVVGDKV 182
Query: 649 SLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSV 828
L+P AG LH S+ LLD+ EVN +N T W++ +F+ F +++ +
Sbjct: 183 VLMP-----VNAGQ---PLHASNVELLDNPGCKEVNAVNCNTSWKITLFMKFSSYREDVL 234
Query: 829 KSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTN 1008
K GDVVRLFHA+Q+ FLT D K+ +FLR T R SA ATSS+ALWE++VV +
Sbjct: 235 KGGDVVRLFHAEQEKFLTCDDYEKKQH----IFLRTTLRQSATSATSSKALWEIEVVHHD 290
Query: 1009 AYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRRASLIYSKTNNPMAMYSDGP 1188
RGG +WN +RFKHLAT YL+AE + P Y N DG
Sbjct: 291 PCRGGAGQWNSLFRFKHLATGNYLAAE-----LNPD---------YRDAQNEGKTVRDGE 336
Query: 1189 NGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLL 1368
T++ + I V P ++ LF+LD +T +++ VPR SYVRL
Sbjct: 337 LP-TSKKKHQAGEKIMYTLVSVPHGNDIAS-----LFELDATTLQRADCLVPRNSYVRLR 390
Query: 1369 HQSSDKWVHATNATEKQNLHYSSKNEKG-WVKVICEKNRVDKETFALLPVNPDEVRDLDF 1545
H ++ WV +T+ + ++ E+ +K+ + + DKE FA++ V EVRDLDF
Sbjct: 391 HLCTNTWVTSTS------IPIDTEEERPVMLKIGTCQTKEDKEAFAIVCVPLSEVRDLDF 444
Query: 1546 ANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPSR 1725
ANDA K L +K ++ G + E T+LL D I FV + +++ D L + P+R
Sbjct: 445 ANDANKVLATTVKKLENGSITQNER-RFVTKLLEDLIFFVADVTNNGQDVLDVVITKPNR 503
Query: 1726 DRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIFKTMFQLCYCL 1905
+RQKL+REQ +L QVF +LKAPF + G D R +K + +LCY +
Sbjct: 504 ERQKLMREQNILAQVFGILKAPFKEKAGE----GSMLRLEDLGDQRYAPYKYVLRLCYRV 559
Query: 1906 LKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFV 2085
L++SQ YRKNQE++A+ F +Q QIG+D++AEDT+TA+LHNN KLLEK++ +E FV
Sbjct: 560 LRHSQQDYRKNQEYIAKNFCVMQSQIGYDILAEDTITALLHNNRKLLEKHITAKEIETFV 619
Query: 2086 ELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKII-------- 2241
L+R NR+ +FLDYL+DLCV A QELIC +LS + DI + TK++
Sbjct: 620 SLLRRNREPRFLDYLSDLCVSNSTAIPVTQELICKFMLSPGNADILIQTKLVSMQVENPM 679
Query: 2242 ----------DGEIEVGWA-----PNFRKLVDIAEGAKSNSD-DAEHLDYYRHQLDLLSQ 2373
D E+ + W P+ + + +A+ A+ + D E L YYR+QL+L ++
Sbjct: 680 ESSILPDDIDDEEVWLYWIDSNKEPHGKAIRHLAQEAREGTKADLEVLTYYRYQLNLFAR 739
Query: 2374 MCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLHLHVVRGS 2553
MC ++QYLAI+ IS QL +L+L+C+SD LP+DLR SF RLMLH+HV R
Sbjct: 740 MCLDRQYLAIN--------QISTQLSVDLILRCVSDESLPFDLRASFCRLMLHMHVDRDP 791
Query: 2554 PMSAI--RHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATVETYLMGL 2727
S + R+ARLW IP + + Y+S++ D SR + A + VE YL +
Sbjct: 792 QESVVPVRYARLWTEIPTKITIHEYDSIT-----DSSRNDMKRKFA-LTMEFVEEYLKEV 845
Query: 2728 RNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIIN--EGPATEQV 2901
NQ +KLT+E+V+LA+ L F FYSF++LL+LT+ LLAI++ + P +
Sbjct: 846 VNQPFPFGDK-EKNKLTFEVVHLARNLIYFGFYSFSELLRLTRTLLAILDIVQAPMSSYF 904
Query: 2902 PSHRAMVNAIRNMSKSMMRGGNKENSKDLAK-----------TPSVTAEEAGRTKEGRAL 3048
+ N+ +++ G L++ PSV + E +
Sbjct: 905 ERLSKFQDGSNNVMRTIHGVGEMMTQMVLSRGSIFPVSWPDAQPSVHPSKQASPGEQEDV 964
Query: 3049 NVK-TKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSAS----------- 3192
V TKL V EILQF++ VR DYRI+ LS +K F + DG+ SAS
Sbjct: 965 TVMDTKLKVIEILQFILSVRLDYRISYMLSIYKKEFG-ENDGNGDPSASGTPETLLPSAL 1023
Query: 3193 ---INERMASELYDAIYRSSGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRH 3363
I+E A R + LD G+ L +L+ + M DY PL S AL++ F+H
Sbjct: 1024 VPDIDEIAAQAETMFAGRKEKTPVQLDDEGGRTFLRVLIHLIMHDYAPLLSGALQLLFKH 1083
Query: 3364 FTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEV 3543
F+Q E+L+ KQVQLLVSN DV+NY+QI DL L+ EKSELWV
Sbjct: 1084 FSQRAEVLQAFKQVQLLVSNQDVDNYKQIKADLDQLRLTVEKSELWV------------- 1130
Query: 3544 DEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRN 3723
+ ++++GD E E NE LL+ +
Sbjct: 1131 ----------------EKSGSYENGDMGEGQAKGGEE-----ANEESNLLSPV------Q 1163
Query: 3724 DAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEF 3903
D A Q S+K Y +++++L+RL+ +C + + K +Q+LLKNM + VVL+
Sbjct: 1164 DGAKTPQIDSNKGN--NYRIVKEILIRLSKLCVQ--NKKCRNQHQRLLKNMGAHSVVLDL 1219
Query: 3904 ISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEE 4083
+ +P++K D M +++ L+H FL++FC+ N +NQ L+K ++ G+L ET+
Sbjct: 1220 LQIPYEKT-DEKMNEVMDLAHTFLQNFCRGNPQNQVLLHKHLNLF--LTPGLLEAETMRH 1276
Query: 4084 VGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEK 4263
IF NN L + + E ++ H V IE + R+ +L LQ +V K ++ Q+
Sbjct: 1277 ------IFMNNYHLCNEISERVVQHFVHCIETHGRHVEYLRFLQTIVKADGKYVKKCQDM 1330
Query: 4264 VANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCT 4443
V E+ ++V Y D ASF L MM E+ D L YHI LV LLA CT
Sbjct: 1331 VMTELINGGEDVLIFYNDRASFPILLNMMCSERAR----GDESGPLAYHITLVELLAACT 1386
Query: 4444 RGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEY 4623
GKN TE+KC S +P+D IVRVVT C+ EVK Y+ + HCY+DT+ EMK+ Y + +
Sbjct: 1387 EGKNVYTEIKCNSLLPLDDIVRVVTHDDCIPEVKIAYVNFVNHCYVDTEVEMKEIYTSNH 1446
Query: 4624 VDHILNNLLEDIRSLRVEKLTGAETAT-LEHYICHTVTEVLIKFFEAPYSALQQAKVDVH 4800
+ + N L D+ + T LE + +V ++ FF +P+S +
Sbjct: 1447 IWKLFENFLVDMARVCNTTTDRKHADTFLERCVTESVMNIVSGFFNSPFS---DNSTSLQ 1503
Query: 4801 HHKKTFSEVLLELTYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQM 4980
H+ F ++L + + V CI+ L + A+ I +P L
Sbjct: 1504 THQPVFIQLLQSAFRIYNCTWPNPAQKAS---VESCIRALAEVAKNRGIAIPVDLD---- 1556
Query: 4981 SGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMM 5160
S ++ K +S+ + +G RL+ ++ L G + N++ +
Sbjct: 1557 SQVNTLFMK--NHSSTVQRAAMGWRLSARSGPRFKEALGGPAWDYR-----NIIEKLQDV 1609
Query: 5161 IGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNK 5340
+ + P+ AE SVLV+VL++PELLFPEGS R +C G ++KLI H K LM+ K
Sbjct: 1610 VASLEQQFSPMMQAEFSVLVDVLYSPELLFPEGSDARIRC--GAFMSKLINHTKKLME-K 1666
Query: 5341 QDNLCARVLQTLCKMCDCTKXXXXXXXXXXXXXXXXRYF--GHHNNHHPPLDRQQSXXXX 5514
++ LC ++LQTL +M + K RYF H + PL +
Sbjct: 1667 EEKLCIKILQTLREMLE-KKDSFMEESSTLRKILLNRYFKGDHSVGVNGPLSGAYAKTAQ 1725
Query: 5515 XXXXXXXXXXXTWSQERD-----LYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLA 5679
Q+ D + IQC L+ GAS+LV D+I+ + IF + I L
Sbjct: 1726 VGGGFT-------GQDADKTGISMSDIQCLLDKEGASELVIDVIVNTKNDRIFSEGILLG 1778
Query: 5680 RALLHEGNDKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRLKSDMMSCSDSKPKVSLS 5859
ALL GN + Q+SFY ++ ++ E FFK + R++ AQ ++S + + + L
Sbjct: 1779 IALLEGGNTQTQNSFYQQLHEQKKSEKFFKVLYDRMKAAQKEIRSTV-----TVNTIDLG 1833
Query: 5860 ATVSRRSSTVLT--PLIDAGDT------GFNGALFEVPQQVRHPSISEMSQLSNDLTHSI 6015
+ S ++ P + D+ G G L E ++ D+
Sbjct: 1834 SKKREEDSDLMALGPRMRVRDSSLHLKEGMKGQLTEASSATSKAYCVYRREMDPDIDTMC 1893
Query: 6016 PDLAPYQDEEKSTD--ALPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVS 6189
P EEKS + + P + ++ PILR LQLLCENHN LQNFLR Q+++TN+NLV
Sbjct: 1894 PGQEAGSAEEKSAEEVTMSPAITIMRPILRFLQLLCENHNRELQNFLRNQNNKTNYNLVC 1953
Query: 6190 ETLSFLDTVCGSTKGSLGVFG-EIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQE-N 6363
ETL FLD +CGST G LG+ G I E N +L+ QTL +LTE+CQGPCHENQ +A E N
Sbjct: 1954 ETLQFLDCICGSTTGGLGLLGLYINEKNVALVNQTLESLTEYCQGPCHENQTCIATHESN 2013
Query: 6364 GLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSG 6543
G++III+L+L++I PL M+L L+ L+N A+
Sbjct: 2014 GIDIIIALILSDINPLGKYRMDLVLQ-------------------------LKNNAS--- 2045
Query: 6544 GPKQLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDA 6723
K L+ ++ ++ N+ + ++L D+ K + Q
Sbjct: 2046 --KLLLAIMESRHDSENAERILFNMRPKELV-----DVMKNAYNQ--------------- 2083
Query: 6724 SGIVSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLD-GSD 6900
G+ H D++ DD V P++VGHNIYILAHQLA H+ L+ L GSD
Sbjct: 2084 -GLECNHG--------DEEGGDD---GVSPKDVGHNIYILAHQLARHNKLLQQMLKPGSD 2131
Query: 6901 EKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDN 7080
++ D EAL YY TAQIEIVR DRT+E++VFP+ +IC +LT+++K V+N TERD
Sbjct: 2132 PEEGD---EALKYYANHTAQIEIVRHDRTMEQIVFPVPNICEFLTRESKYRVFNTTERDE 2188
Query: 7081 QGSKVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYY 7260
QGSKV +FF + E +Y+EM WQ+K+++ L W + + LW +SF+ A +N VA +Y
Sbjct: 2189 QGSKVNDFFQQTEDLYNEMKWQKKIRNNPALFWFSRHISLWGSISFNLAVFINLAVALFY 2248
Query: 7261 PLPEHSNSSISLGNLYS---WFAV-FSSFLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXX 7428
P + + +L L+S W AV + +L + + I
Sbjct: 2249 PFGDDGDEG-TLSPLFSALLWVAVAICTSMLFFFSKPVGI------RPFLVSIMLRSIYT 2301
Query: 7429 IGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRNLHYLLVYLFICILGLL 7608
IG+ TL + G L NKIV +V+FV N+G R ++ Y + Y+ +C+LGL
Sbjct: 2302 IGLGPTLILLGAANLCNKIVFLVSFVGNRGTFTRGYRAVILDMAFLYHVAYVLVCMLGLF 2361
Query: 7609 VHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDF 7788
VH Y LLFD+++ EETL NVI SVTRN +SI+ T +LALIL+Y FSI+GFL+ + DF
Sbjct: 2362 VHEFFYSFLLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSIIGFLFLKDDF 2421
Query: 7789 YLEVDPVENDSSATISSGIPSET-------CPSEGCPGLQPSXXXXXXXXXXXX--SCET 7941
+EVD ++N + T + G+P+ T CP E C PS +C+T
Sbjct: 2422 TMEVDRLKNRTPVTGNDGVPTMTLTSMLGTCPKENCSPTIPSSNAAGEGGEDGIERTCDT 2481
Query: 7942 LWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTXXXXXXXXXXXXXXXXXX 8121
L MCI+ QGLRNGGG+GDVLR P+ E +F RV YD+
Sbjct: 2482 LLMCIVTVLNQGLRNGGGVGDVLRRPSKDEPLFAARVVYDLLFFFIVIIIVLNLIFGVII 2541
Query: 8122 DTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLYYIVMLQI 8301
DTF DLR+EK +KE+ILK CFICGL+R +FDN++V+FE H ++EHN+WHYLY+IV++++
Sbjct: 2542 DTFADLRSEKQKKEKILKTTCFICGLERDKFDNKTVSFEEHIKSEHNMWHYLYFIVLVKV 2601
Query: 8302 KDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLLQMMTLMR 8481
KD TE+TGPESYVAQ + ++NLDWFPRM+A+SL +E D++Q+E++ ++++L M+L++
Sbjct: 2602 KDPTEYTGPESYVAQMITEKNLDWFPRMRAMSLVSNEGDSEQNEIRNLQEKLESTMSLVK 2661
Query: 8482 EIISQNEESRAFMEQ 8526
++ Q E + M +
Sbjct: 2662 QLSGQLAELKEQMTE 2676
>gi|18307586|dbj|BAB84088.1| inositol 1,4,5-trisphosphate receptor
[Asterina pectinifera]
Length = 2698
Score = 1621 bits (4197), Expect = 0.0
Identities = 1061/2904 (36%), Positives = 1529/2904 (52%), Gaps = 98/2904 (3%)
Frame = +1
Query: 109 LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
LH GDI+SLY E S N GF+STLGLVDDRC+V+ G +PPKKFRDCLFK+CP+N
Sbjct: 9 LHFGDIVSLYAEGSVN----GFISTLGLVDDRCVVQPDFGDLNNPPKKFRDCLFKICPMN 64
Query: 289 RYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQ 468
RY AQK W K S D L+ KL+ AA+ E+++NE+E +K +G+VI YG+++Q
Sbjct: 65 RYTAQKQFWKSAK--PNVSSATDAVLLKKLQHAAEMEKKQNETENKKLMGSVIVYGNVIQ 122
Query: 469 LLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKI 648
LLH+KS+KY+TV K PA E+NAM+V LD + EGSWF I P YK + GDNV G+K+
Sbjct: 123 LLHIKSHKYMTVNKRLPALLEKNAMRVTLDSSATEGSWFYIVPFYKLRSAGDNVVVGDKV 182
Query: 649 SLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSV 828
L P AG LH S++ L+D+ EVN +N T W+V +F+ EN + +
Sbjct: 183 VLNP-----VNAGQ---PLHPSNYELIDNPGCKEVNSVNCNTCWKVSLFMEHKENL-DGL 233
Query: 829 KSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTN 1008
K GDVVRLFHA+Q+ FLT D K++ +FLR T R SA ATSS+ALWE +VVQ +
Sbjct: 234 KGGDVVRLFHAEQEKFLTCDEYKKKS----YIFLRTTGRVSATAATSSKALWETEVVQHD 289
Query: 1009 AYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRRASLIYSKTNNPMAMYSDGP 1188
RGG WN +RFKHLAT Y++AE K + GP
Sbjct: 290 PCRGGAGHWNSLFRFKHLATGQYMAAEVDNDNTKDHTREKLR----------------GP 333
Query: 1189 NGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLL 1368
+G T Q +P + D +F+LDP+T + VPR SYVRL
Sbjct: 334 HG------GTVYQMVPIIH----------GNDIASIFELDPTTLQGGDSMVPRSSYVRLR 377
Query: 1369 HQSSDKWVHATNATEKQNLHYSSKNEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFA 1548
H ++ WVH+T+ + +++ +KV + R D+E FA++PV+P EVRDLDFA
Sbjct: 378 HLCTNTWVHSTSIPLDKG-----EDKPVMLKVGTAQIREDREAFAIIPVSPTEVRDLDFA 432
Query: 1549 NDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRD 1728
NDA K L ++ + E TQLL D + FV+ ++ D L + +P RD
Sbjct: 433 NDANKVLSAIASKLEKSSITQNERF--VTQLLTDLVYFVSILPNNGGDALNVVVQNPDRD 490
Query: 1729 RQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIFKTMFQLCYCLL 1908
RQKL+REQ++L Q+F +LKAPF T D R+ ++ + +LCY +L
Sbjct: 491 RQKLMREQDILKQIFKILKAPF-----TDNGDGAMLKMEELADPRHAPYRHICRLCYRIL 545
Query: 1909 KYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVE 2088
+ SQ +YRKNQE++A++FG +Q+QIG+D++AEDT+TA+LHNN KLLEK++ +E FV
Sbjct: 546 RLSQQAYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKHITATEIETFVN 605
Query: 2089 LVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVG-- 2262
LVR N + +FL+YL+DLCV +A QELIC SVL ++ DI ++TK++ ++EV
Sbjct: 606 LVRKNGECRFLEYLSDLCVSNNQAIPVTQELICKSVLVERNSDILIETKLVRTQMEVEME 665
Query: 2263 -----------------------WAPNFR-KLVDIAEGAKSN-SDDAEHLDYYRHQLDLL 2367
W + K + G N +DA L YYR+QLDL
Sbjct: 666 VEADDGTTEPVYTIEEEEEVVLFWKNGTKSKSIRSCHGGTENVKEDANVLKYYRYQLDLF 725
Query: 2368 SQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLHLHVVR 2547
SQMC ++QYLAI+ I QL +L+ +CMSD LPYDLR SFTRLMLH+HV R
Sbjct: 726 SQMCLDRQYLAIN--------QIGPQLDIDLIHRCMSDESLPYDLRASFTRLMLHMHVDR 777
Query: 2548 G--SPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATVETYLM 2721
++ +++A LW IP + + Y+ + ++ + + K VE YL
Sbjct: 778 DPKEQVTPVKYAELWSEIPTQITIDDYDGANNLTHAGKEDAQPKFSLTIKF---VEEYLC 834
Query: 2722 GLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIIN----EGPA 2889
+ + + +KLT+E+VNLAK L F FYSF++LL+LT+ LL+I++ G A
Sbjct: 835 NVVSGVLVVYDK-EQNKLTFEVVNLAKHLIYFGFYSFSELLRLTKTLLSILDCTALHGTA 893
Query: 2890 TEQVPSHRAM--------VNAIRNMSKSMMRGGNKEN--SKDLAKTPSVTAEEAGRTKEG 3039
++ + ++ + + +M+ G ++D A + + E
Sbjct: 894 PGKLDPKADIGKGGVFRSIHGVGAVMTNMVLGKRLPTPVTRDPAWPLGWGLDNHNKQDE- 952
Query: 3040 RALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMAS-- 3213
L ++TKL + +ILQF+++VR DYRI+ LS FK F +D + + S AS
Sbjct: 953 --LVMETKLKIIQILQFILNVRLDYRISCLLSIFKRDFDESKDSTDEITTSGKVWTASDF 1010
Query: 3214 ----ELYDAIYRSSGHELHLDGRD---GQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQ 3372
E + I+ S LD D G+ L +L+ +TM DY PL S AL++ F+HF+Q
Sbjct: 1011 EHIEEQAEGIFGGSEENTPLDLDDDDGGRTFLRVLIHLTMHDYAPLVSGALQLLFKHFSQ 1070
Query: 3373 YQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEK 3552
QE+LE KQ+QLLVS+ DV+NY+QI +DL L+ L EKSELWV+ + + +D
Sbjct: 1071 RQEVLEAFKQLQLLVSSQDVDNYKQIKQDLDQLR-LVEKSELWVYKGQG---PDEPMDGA 1126
Query: 3553 ERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAA 3732
EH + P +S S
Sbjct: 1127 SGEQEHKKTEEGTSKPLKHESTSSYN---------------------------------- 1152
Query: 3733 VALQELSDKAPLIAYPLIRQMLVRLTGM-CYR-KGDPKPDTMNQQLLKNMRVYEVVLEFI 3906
Y +++++L+RL+ + C G K Q+LL+NM + VVLE +
Sbjct: 1153 --------------YRVVKEILLRLSKLVCVEGNGTRKNRKHEQRLLRNMGAFTVVLELL 1198
Query: 3907 SVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEV 4086
+P++K HD M +L+ L+HEFL++FC N NQ L+K I + + E
Sbjct: 1199 QIPYEKNHDTRMNELMRLAHEFLQNFCWANPSNQVLLHKHID--------LFLTPGLLEA 1250
Query: 4087 GTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKV 4266
T+ IF NN +L S V E+++ H V I + R+ +L+ LQA+V + I Q+ V
Sbjct: 1251 QTMCHIFMNNFQLCSEVTEQVVQHFVHCIATHGRHVQYLKFLQAIVKADGQYIRKTQDMV 1310
Query: 4267 ANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTR 4446
E+ A ++V Y D ASF+ MM+ E+E SS S+ + H L CT
Sbjct: 1311 MAELVNAGEDVLLFYNDKASFQMFINMMRTERERMDASSPSQYR---HQPWTLLGLACTE 1367
Query: 4447 GKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYV 4626
GKN TE+KC S +P+D IVRV T + CL EVK Y+ L HCY+DT+ EMK+ Y + +V
Sbjct: 1368 GKNVYTEIKCHSLLPLDDIVRVATHEDCLPEVKNAYINFLNHCYVDTEVEMKEIYTSNHV 1427
Query: 4627 DHILNNLLEDIRSL-RVEKLTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHH 4803
++ N L D+ + LE + TV ++ FF +P++ V
Sbjct: 1428 WNLFENFLVDMAMVCNATHDRKHHDHMLEKTVTETVMNIITMFFSSPFA---DQSTTVQT 1484
Query: 4804 HKKTFSEVLLELTYLEKGKLRGSK----SSRNWYRVAECIKRLTKWAEEHNITLPATLAG 4971
+ F +L +G R S+ + Y V CIK LT A+ I +P L
Sbjct: 1485 RQPVFVRLL-------QGAFRVSQCDWLTGHQKYHVENCIKTLTDIAKNRGIAIPVDLD- 1536
Query: 4972 PQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCY 5151
S ++ K + W+ I +R + + +++
Sbjct: 1537 ---SQVNTLFSKSIVMKHTRHWLAINPNRSRDSMV------------AISRDYRSIIEGL 1581
Query: 5152 HMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLM 5331
++ + L PL AE SVLV+VLH PELLFP R +C G ++KLI+H + L+
Sbjct: 1582 QDIVSLLEDQLRPLVQAELSVLVDVLHRPELLFPFRHRARQKCESGAFISKLIKHTEKLL 1641
Query: 5332 QNKQDNLCARVLQTLCKMCDCTKXXXXXXXXXXXXXXXXRYFGHHNNHHPPLDRQQSXXX 5511
+ K++ LC +VLQTL +M RY+G + S
Sbjct: 1642 EEKEEKLCIKVLQTLKEMM-TVDIDYSEKGEDLRQCLLLRYYGKSHLRMKHRGVVASGRG 1700
Query: 5512 XXXXXXXXXXXXTWSQ-ERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARAL 5688
S+ E L +QC+L+ GAS LV D++I S +FL+++ L AL
Sbjct: 1701 QTNVTSCGPGSRVLSRAEMTLAEVQCQLDKEGASSLVIDLVIKNSSNRVFLESVELGIAL 1760
Query: 5689 LHEGNDKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRLKSDMM-----SCSDSKPKVS 5853
L GN +Q S + E FFK R++ A + +K+ + +KP
Sbjct: 1761 LEGGNTNIQKSIINCLMSDKNSEKFFKVFFDRMREA-SEIKATVTVNTGEGIGQTKPTEG 1819
Query: 5854 LSATVSRRSSTVLTPLIDAGDT---------GFNGALFEVPQQVRHPSISEMSQLSNDLT 6006
+ RR LT + G T + L + S + L
Sbjct: 1820 RNGQHLRRR---LTWPHEKGWTRPQRLNQRRAEDQLLADAALHTSKASRQSARVATTTLL 1876
Query: 6007 HSIPDLAPYQDEEKSTDALPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLV 6186
S LA ++ K + + E+A+++PILR LQLLCENHN LQ++LR Q+++TN+NLV
Sbjct: 1877 ASCQVLAGGAEKAKEEEKMSMEIAIMQPILRFLQLLCENHNRELQSYLRHQNNKTNYNLV 1936
Query: 6187 SETLSFLDTVCGSTKGSLGVFG-EIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQE- 6360
ETL FLD +CGST G LG+ G I E+N +LI QTL +LTE+CQG CHENQN +A E
Sbjct: 1937 CETLQFLDCICGSTTGGLGLLGLYINENNVALINQTLESLTEYCQGACHENQNAIANHES 1996
Query: 6361 NGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMS 6540
NGL+II +L+LN+I PL + M+L LE+K+ ASKLLLAIMESRHD ENA R+L NM+
Sbjct: 1997 NGLDIITALILNDINPLGKNRMDLVLELKNNASKLLLAIMESRHDSENAERILLNMS--- 2053
Query: 6541 GGPKQLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVD 6720
PKQLV IKQAY+ DL R +D+L
Sbjct: 2054 --PKQLVDVIKQAYQ------------QEDLERDDDDEL--------------------- 2078
Query: 6721 ASGIVSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSD 6900
++D ++ PREVGHNIYILAHQLA H+ EL L +
Sbjct: 2079 --------------------IIEEDDEAISPREVGHNIYILAHQLAHHNKELAALLKPTG 2118
Query: 6901 EKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDN 7080
+ T AL YY + TAQIEIVR+DRT+E++VFP+ +C YLT +TK V+ ERD+
Sbjct: 2119 -PNSEYTDRALEYYFKHTAQIEIVRQDRTMEQIVFPVPQLCEYLTAETKIKVFTKAERDD 2177
Query: 7081 QGSKVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYY 7260
QGSKV +FF++ E M+ EM WQ+KL+ + L + + W+ + F+ A IVN LVA +Y
Sbjct: 2178 QGSKVADFFEKTEDMFMEMKWQKKLRAQPILFLASSNMSKWSLVCFNLAVIVNLLVAFFY 2237
Query: 7261 PLPEHSNSSISLGNLYSWFAVFSSFLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVT 7440
P + ++ W S + R I IGV
Sbjct: 2238 PFDVTTTELDHGLSMLVWLMAASLAAIVTLRRPSGI-----RPLVFATILRMLIFSIGVE 2292
Query: 7441 LTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPM 7620
TL +L + NK + +++F+ N GL + + I + Y ++YL IC LGL VH
Sbjct: 2293 PTLLFLAVLTIFNKCIFILSFLGNCGLLYKGVRGIFTDMEVLYHILYLIICFLGLFVHEF 2352
Query: 7621 IYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEV 7800
Y +LL D+++ E+TL NVI SVTRN++SI +T LLALIL+Y FSI+G+L+ + DF EV
Sbjct: 2353 FYSLLLLDVVYQEDTLINVIHSVTRNWRSIAFTALLALILVYLFSIVGYLFLQDDFVYEV 2412
Query: 7801 DPVE---NDSSATISSGI-PSETCPSEGCP-GLQPS-----------------XXXXXXX 7914
+P+ ++AT +G P P E CP GL+
Sbjct: 2413 NPLRPAIATATATNKTGTSPPMPLPPESCPAGLEMEDCLKNNLSHVQAKEVSYDSGIEVG 2472
Query: 7915 XXXXXSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTXXXXXXXXX 8094
+CETL M I+ T G+R+GGGIGDVLR+P+ E +++ RV YD+
Sbjct: 2473 TERERACETLIMYIITTLNFGVRSGGGIGDVLRSPSTREPLYMARVIYDLLFFIVVIIIV 2532
Query: 8095 XXXXXXXXXDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHY 8274
DTF DLR+EK +KE+ILKN CFICGL+RS FDN+SV+FE H + EH++WHY
Sbjct: 2533 LNLIFGVIIDTFADLRSEKQQKEEILKNTCFICGLNRSSFDNKSVSFEEHYKEEHSMWHY 2592
Query: 8275 LYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQ 8454
LY+IV++++KD TEFTGPESYV K++N DWFPRM+A+SL E +++Q+E++ +++Q
Sbjct: 2593 LYFIVLVKVKDPTEFTGPESYVYNMTKEKNQDWFPRMRAMSLDSDEGESEQNEMRILQNQ 2652
Query: 8455 LLQMMTLMREIISQNEESRAFMEQ 8526
L +L++ + Q E + M +
Sbjct: 2653 LENTNSLVKVLSGQLRELKDQMTE 2676
>gi|27807313|ref|NP_777266.1| inositol 1,4,5-triphosphate receptor,
type 1 [Bos taurus]
gi|17367101|sp|Q9TU34|IP3R_BOVIN Inositol 1,4,5-trisphosphate
receptor type 1 (Type 1 inositol 1,4,5-trisphosphate
receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform
1) (InsP3R1)
gi|6006803|gb|AAF00613.1| inositol 1,4,5-trisphosphate receptor type
I [Bos taurus]
Length = 2709
Score = 1612 bits (4175), Expect = 0.0
Identities = 1061/2903 (36%), Positives = 1556/2903 (53%), Gaps = 110/2903 (3%)
Frame = +1
Query: 109 LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
LHIGDI SLY E S+N GF+STLGLVDDRC+V+ + G +PPKKFRDCLFK+CP+N
Sbjct: 9 LHIGDICSLYAEGSTN----GFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKLCPMN 64
Query: 289 RYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQ 468
RY+AQK W K +S D L+NKL AAD E+++NE+E +K LG VIQYG+++Q
Sbjct: 65 RYSAQKQFWKAAK--PGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQ 122
Query: 469 LLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKI 648
LLH+KSNKY+TV K PA E+NAM+V LD AGNEGSWF I+P YK +IGD+V G+K+
Sbjct: 123 LLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGDKV 182
Query: 649 SLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSV 828
L P AG LH SS L+D+ EVN +N T W++ +F+ + +N+ + +
Sbjct: 183 VLNP-----VNAGQ---PLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDIL 234
Query: 829 KSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTN 1008
K GDVVRLFHA+Q+ FLT D K+ VFLR T R SA ATSS+ALWEV+VVQ +
Sbjct: 235 KGGDVVRLFHAEQEKFLTCDEHRKKQH----VFLRTTGRQSATSATSSKALWEVEVVQHD 290
Query: 1009 AYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRRASLIYSKTNNPMAMYSDGP 1188
RGG WN +RFKHLAT YL+AE V P L + + +P D
Sbjct: 291 PCRGGAGYWNSLFRFKHLATGHYLAAE-----VDPDFE--EECLEFQPSVDPD---QDAS 340
Query: 1189 NGVTNESTDTTQQNIPSVWVLGPTKSEFPE-EDANLLFQLDPSTFMKSNKEVPRRSYVRL 1365
+ + ++ SV PE D + +F+LDP+T + VPR SYVRL
Sbjct: 341 RSRLRNAQEKMVYSLVSV----------PEGNDISSIFELDPTTLRGGDSLVPRNSYVRL 390
Query: 1366 LHQSSDKWVHATNATEKQNLHYSSKNEKG-WVKVICEKNRVDKETFALLPVNPDEVRDLD 1542
H ++ WVH+TN + + EK +K+ + DKE FA++PV+P EVRDLD
Sbjct: 391 RHLCTNTWVHSTN------IPIDKEEEKPVMLKIGTSPVKEDKEAFAIVPVSPAEVRDLD 444
Query: 1543 FANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPS 1722
FANDA K L + ++ G + E S T+LL D + FVT ++ D L++ P+
Sbjct: 445 FANDASKVLGSIAGKLEKGTITQNER-RSVTKLLEDLVYFVTGGTNSGQDVLEVVFSKPN 503
Query: 1723 RDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIFKTMFQLCYC 1902
R+RQKL+REQ +L Q+F LL+APF T D R+ F+ + +LCY
Sbjct: 504 RERQKLMREQNILKQIFKLLQAPF-----TDCGDGPMLRLEELGDQRHAPFRHICRLCYR 558
Query: 1903 LLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERF 2082
+L++SQ YRKNQE++A++FG +Q+QIG+D++AEDT+TA+LHNN KLLEK++ ++ F
Sbjct: 559 VLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKHITAAEIDTF 618
Query: 2083 VELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKII------- 2241
V LVR NR+ +FLDYL+DLCV ++ QELIC +VL+ + DI ++TK++
Sbjct: 619 VSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETKLVLSRFEFE 678
Query: 2242 --------------DGEIEVGWAPNFRKLV-----DIAEGAKSNS-DDAEHLDYYRHQLD 2361
+ E+ V W + +++ ++A+ AK +D + L YYR+QL+
Sbjct: 679 GVSTGENALEAGEDEEEVWVFWRDSNKEVRSKSVRELAQDAKEGQKEDRDVLGYYRYQLN 738
Query: 2362 LLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLHLHV 2541
L ++MC ++QYLAI+ IS QL +L+L+CMSD LP DLR SF RLMLH+HV
Sbjct: 739 LFARMCLDRQYLAIN--------EISGQLDVDLILRCMSDENLPSDLRASFCRLMLHMHV 790
Query: 2542 VRG--SPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATVETY 2715
R ++ +++ARLW IP + + Y+S S S+ I E A + + VE Y
Sbjct: 791 DRDPQEQVTPVKYARLWSEIPSEIAIDDYDS------SGTSKDEIKERFA-QTMEFVEEY 843
Query: 2716 LMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINEGPATE 2895
L + Q +KLT+E+VNLA+ L F FY+F+DLL+LT+ LLAI++ T
Sbjct: 844 LRDVVCQRFPFSDK-EKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCVHVTT 902
Query: 2896 QVPSHRAMV-------NAIRN-------MSKSMMRGGNKENSKDLAKTPSVTAEEAGRTK 3033
P + N +R+ M++ ++RGG A P ++A K
Sbjct: 903 IFPISKMAKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPTATAPEGNVKQAEPEK 962
Query: 3034 EGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFP-------------CDEDGS 3174
E + + TKL + EILQF+++VR DYRI+ L FK F ++G
Sbjct: 963 ED-IMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQTSETSSGNSSQEGP 1021
Query: 3175 LMHSASINERMASELYDAIYRSSGHE--LHLDGRDGQLLLAILLQMTMSDYPPLTSIALK 3348
+++ E + I+ S L LD G+ L +LL +TM DYPPL S AL+
Sbjct: 1022 SNVPGALDFEHIEEQAEGIFGGSEETTPLDLDDHGGRTFLRVLLHLTMHDYPPLVSGALQ 1081
Query: 3349 VFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSI 3528
+ FRHF+Q QE+L+ KQVQLLV++ DV+NY+QI +DL D+ SI
Sbjct: 1082 LLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDL----------------DQLRSI 1125
Query: 3529 DTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLI 3708
K +L + + P G S E NEH +
Sbjct: 1126 VEKS----------ELWVYKGQGPDEAMDGASGE------NEHKKT-------------- 1155
Query: 3709 KDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDP--KPDTMNQQLLKNMRV 3882
++ N+ + + S Y +++++L+RL+ +C ++ K Q+LL+NM
Sbjct: 1156 -EEGNNKSQQHESTSS----YNYRVVKEILIRLSKLCVQESASVRKSRKQQQRLLRNMGA 1210
Query: 3883 YEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGML 4062
+ VVLE + +P++K D M +++ L+HEFL++FC N NQ+ L+K I+ + G+L
Sbjct: 1211 HAVVLELLQIPYEKAEDTMMQEIMRLAHEFLQNFCAGNHPNQALLHKHINLFLNP--GIL 1268
Query: 4063 RVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKE 4242
T++ IF NN +L S + E ++ H V IE + RN +++ LQ +V K
Sbjct: 1269 EAVTMQH------IFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAEGKF 1322
Query: 4243 IESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELV 4422
I+ Q+ V E+ + ++V Y D ASF+ L MM+ E++ D L YHI LV
Sbjct: 1323 IKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERDRM----DENSPLMYHIHLV 1378
Query: 4423 RLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMK 4602
LLA+CT GKN TE+KC S +P+D IVRVVT + C+ EVK Y+ L HCY+D + EMK
Sbjct: 1379 ELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCYVDPEVEMK 1438
Query: 4603 DAYKTEYVDHILNNLLEDI-RSLRVEKLTGAETATLEHYICHTVTEVLIKFFEAPYSALQ 4779
+ Y + ++ + N L DI R+ + LE Y+ V ++ FF +P+S
Sbjct: 1439 EIYTSNHMWKLFENFLVDICRACNNTSDRKHADSILEKYVTEIVMSIVTTFFSSPFS--- 1495
Query: 4780 QAKVDVHHHKKTFSEVLLEL--TYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNITL 4953
+ + F ++L + Y + K+S V CI+ L+ A+ I +
Sbjct: 1496 DQSTTLQTRQPVFVQLLQGVFRVYHCNWLMPSQKAS-----VESCIRVLSDVAKSRAIAI 1550
Query: 4954 PATLAGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHTSA 5133
P L + Q+ A + W + R++++ P R Y
Sbjct: 1551 PVDLDSQVNNLFLKSHNLVQKTAMN--WRLTARNAARRDSVLPVSRDY-----------R 1597
Query: 5134 NVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQ 5313
N++ ++ + L PL AE SVLV+VLH PELLFPE + R +C GG + KLI+
Sbjct: 1598 NIIERLQDIVSALEDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKCESGGFICKLIK 1657
Query: 5314 HCKTLMQNKQDNLCARVLQTLCKMCDCTKXXXXXXXXXXXXXXXXRYFGHHNNHHPPLDR 5493
H K L++ ++ LC +VLQTL +M + RY+G+ P R
Sbjct: 1658 HTKQLLEENEEKLCIKVLQTLREMMTKDRGYGEKGEALRQILVN-RYYGNIR----PSGR 1712
Query: 5494 QQSXXXXXXXXXX-------------XXXXXTWSQERDLYAIQCKLNDAGASDLVTDIII 5634
++S E L +QC L+ GAS+LV D+I+
Sbjct: 1713 RESLTSFGNGPLSPGGPSKPGGGGGGSGSSPMSRGEMSLAEVQCHLDKEGASNLVIDLIM 1772
Query: 5635 MEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRLKS 5814
S +F ++I LA ALL GN +QHSF+ R+ + E FFK R++ AQ +K+
Sbjct: 1773 NASSDRVFHESILLAIALLEGGNTTIQHSFFCRLTEDKKSEKFFKVFYDRMKVAQQEIKA 1832
Query: 5815 DM-MSCSDSKPK-----VSLSATVSRRSSTVLTPLIDAGDTGFNGALFEVPQQVRHPSIS 5976
+ ++ SD K V A +++ T + + EV Q+ S +
Sbjct: 1833 TVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPATQITE-----------EVRDQLLEASAA 1881
Query: 5977 EMSQLSNDLTHSIPDLAPYQDEE-------KSTDALPPE--VALVEPILRVLQLLCENHN 6129
+ + PD YQ E KS D L + +++PILR LQLLCENHN
Sbjct: 1882 TRKAFTTFRREADPD-DHYQSGEGAQAAADKSKDDLEMSAVITIMQPILRFLQLLCENHN 1940
Query: 6130 SLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFG-EIGEHNFSLITQTLATLT 6306
LQNFLR Q+++TN+NLV ETL FLD +CGST G LG+ G I E N +LI QTL +LT
Sbjct: 1941 RDLQNFLRCQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINEKNVALINQTLESLT 2000
Query: 6307 EFCQGPCHENQNTMAMQE-NGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIME 6483
E+CQGPCHENQN +A E NG++II +L+LN +I K + ++E
Sbjct: 2001 EYCQGPCHENQNCIATHESNGIDIITALILN--------------DINPLGKKRMDLVLE 2046
Query: 6484 SRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLKK 6663
L+N A+ K L+ ++ ++ N+ + ++L ++ K
Sbjct: 2047 -----------LKNNAS-----KLLLAIMESRHDSENAERILYNMRPKELV-----EVIK 2085
Query: 6664 KSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNIYIL 6843
K+ Q V +D N +D + PR VGHNIYIL
Sbjct: 2086 KAYMQGEVE--------------------------FEDGENGED-GAASPRNVGHNIYIL 2118
Query: 6844 AHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPINDIC 7023
AHQLA H+ EL+ L + D E L++Y + T EIVR DRT+E++VFP+ IC
Sbjct: 2119 AHQLARHNKELQTMLKPGGQVDGD---ETLDFYAQPTGPNEIVRLDRTMEQIVFPVPSIC 2175
Query: 7024 SYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPLW 7203
+LTK++K +Y TERD QGSK+ +FF E +++EM WQ+KL+ + L WCA + W
Sbjct: 2176 EFLTKESKLRIYYTTERDEQGSKINDFFLRSEDLFNEMNWQKKLRAQPVLYWCARNMSFW 2235
Query: 7204 TRLSFHFAFIVNALVARYYPLPEHSNSSIS---LGNLYSWFAVFSSFLLAHYLRHDKIYL 7374
+ +SF+ A ++N LVA +YP ++ G L++ + + ++A H
Sbjct: 2236 SSISFNLAVLMNLLVAFFYPFKGVRGGTLEPHWSGLLWTAMLISLAIVIALPKPHG---- 2291
Query: 7375 HKTXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILAC 7554
+G+ TL++ G + NKI+ +++FV N G R ++
Sbjct: 2292 ---IRALIASTILRLIFSVGLQPTLFLLGAFNVCNKIIFLMSFVGNCGTFTRGYRAMVLD 2348
Query: 7555 RNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLAL 7734
Y L+ L IC +GL VH Y +LLFD+++ EETL NVI SVTRN +SI+ +LAL
Sbjct: 2349 VEFLYHLLXLLICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRSIILMAVLAL 2408
Query: 7735 ILLYFFSILGFLYFRHDFYLEVDPVENDSS------ATISSGIPSETC---PSEGCPGLQ 7887
IL+Y FSI+G+L+F+ DF LEVD + N++S + S + S+ C E C
Sbjct: 2409 ILVYLFSIVGYLFFKDDFILEVDRLPNETSLPEASESLASEFLYSDVCRVETGENCSSPA 2468
Query: 7888 PSXX---XXXXXXXXXXSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAY 8058
P +CETL MCI+ GLR+GGG+GDVLR P+ E +F RV Y
Sbjct: 2469 PKEELVPAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVIY 2528
Query: 8059 DMTXXXXXXXXXXXXXXXXXXDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFE 8238
D+ DTF DLR+EK +KE+ILK CFICGL+R +FDN++VTFE
Sbjct: 2529 DLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVTFE 2588
Query: 8239 THRETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELD 8418
H + EHN+WHYL +IV++++KD TE+TGPESYVA+ +K+RNLDWFPRM+A+SL S+ +
Sbjct: 2589 EHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFPRMRAMSLVSSDSE 2648
Query: 8419 TDQSEVKQMKDQLLQMMTLMREI 8487
+Q+E++ ++++L M L+ +
Sbjct: 2649 GEQNELRNLQEKLESTMKLVTNL 2671
>gi|4504795|ref|NP_002215.1| inositol 1,4,5-triphosphate receptor,
type 3 [Homo sapiens]
gi|1082540|pir||A49873 inositol 1,4,5-triphosphate receptor, type 3 -
human
gi|393036|gb|AAC50064.1| human type 3 inositol 1,4,5-trisphosphate
receptor
Length = 2671
Score = 1582 bits (4095), Expect = 0.0
Identities = 1045/2904 (35%), Positives = 1545/2904 (52%), Gaps = 94/2904 (3%)
Frame = +1
Query: 109 LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
LHIGDI+SLY E S N GF+STLGLVDDRC+VE G ++PPKKFRDCLFKVCP+N
Sbjct: 8 LHIGDIVSLYAEGSVN----GFISTLGLVDDRCVVEPAAGDLDNPPKKFRDCLFKVCPMN 63
Query: 289 RYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQ 468
RY+AQK W ++ Q + + D L+ KL+ AA E+++N++E +K G+V++YGS++Q
Sbjct: 64 RYSAQKQYWKAKQTKQDKEKIADVVLLQKLQHAAQMEQKQNDTENKKVHGDVVKYGSVIQ 123
Query: 469 LLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKI 648
LLH+KSNKY+TV K PA E+NAM+V LD GNEGSW I+P +K + GDNV G+K+
Sbjct: 124 LLHMKSNKYLTVNKRLPALLEKNAMRVTLDATGNEGSWLFIQPFWKLRSNGDNVVVGDKV 183
Query: 649 SLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSV 828
L P AG LH S++ L D+ EVN +N T W++ +F+ F ++ + +
Sbjct: 184 ILNP-----VNAG---QPLHASNYELSDNAGCKEVNSVNCNTSWKINLFMQFRDHLEEVL 235
Query: 829 KSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTN 1008
K GDVVRLFHA+Q+ FLT D + VFLR T R SA ATSS ALWEV+VV +
Sbjct: 236 KGGDVVRLFHAEQEKFLTCDEYKGKLQ----VFLRTTLRQSATSATSSNALWEVEVVHHD 291
Query: 1009 AYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRRASLIYSKTNNPMAMYSDGP 1188
RGG WN YRFKHLAT YL+AE + A + + A M + G
Sbjct: 292 PCRGGAGHWNGLYRFKHLATGNYLAAEENPSYKGDASDPKAA-----------GMGAQGR 340
Query: 1189 NGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLL 1368
G N + I V P + D LF+LDP+T K++ VPR SYVRL
Sbjct: 341 TGRRNAG-----EKIKYCLVAVPHGN-----DIASLFELDPTTLQKTDSFVPRNSYVRLR 390
Query: 1369 HQSSDKWVHATNATEKQNLHYSSKNEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFA 1548
H ++ W+ +TN + + + C + DKE FA++ V E+RDLDFA
Sbjct: 391 HLCTNTWIQSTNVP----IDIEEERPIRLMLGTC-PTKEDKEAFAIVSVPVSEIRDLDFA 445
Query: 1549 NDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRD 1728
NDA L + ++ + G IS+ QLL D + FV++ ++ + L I P+R+
Sbjct: 446 NDASSMLASAVEKLNEG-FISQNDRRFVIQLLEDLVFFVSDVPNNGQNVLDIMVTKPNRE 504
Query: 1729 RQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIFKTMFQLCYCLL 1908
RQKL+REQ +L QVF +LK PF + G D +N ++ MF+LCY +L
Sbjct: 505 RQKLMREQNILKQVFGILKVPFREKGG----EGPLVRLEELSDQKNAPYQHMFRLCYRVL 560
Query: 1909 KYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVE 2088
+YSQ YRKNQE +A++FG +Q QIG+D++AEDT+TA+LHNN KLLEK++ VE FV
Sbjct: 561 RYSQEDYRKNQEHIAKQFGMMQSQIGYDILAEDTITALLHNNRKLLEKHITKTEVETFVS 620
Query: 2089 LVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKI---------- 2238
LVR NR+ +FLDYL+DLCV A QELIC VL K+ DI + T++
Sbjct: 621 LVRKNREPRFLDYLSDLCVSNHIAIPVTQELICKCVLDPKNSDILIRTELRPVKEMAQSH 680
Query: 2239 -------IDGEIEVGWAP-----NFRKLVDIAEGAKS-NSDDAEHLDYYRHQLDLLSQMC 2379
+ E+ + W + + + +A+ A++ N+ D L YYR+QL L ++MC
Sbjct: 681 EYLSIEYSEEEVWLTWTDKNNEHHEKSVRQLAQEARAGNAHDENVLSYYRYQLKLFARMC 740
Query: 2380 QEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLHLHVVRGSP- 2556
++QYLAID ISQQL +L+ CM+D LP+DLR SF LMLH+HV R
Sbjct: 741 LDRQYLAID--------EISQQLGVDLIFLCMADEMLPFDLRASFCHLMLHVHVDRDPQE 792
Query: 2557 -MSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATVETYLMGLRN 2733
++ ++ ARLW IP + + Y+S ++ A D + + + VE YL + +
Sbjct: 793 LVTPVKFARLWTEIPTAITIKDYDS-NLNASRDDKKNKFA-----NTMEFVEDYLNNVVS 846
Query: 2734 QSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIIN--EGPATEQVPS 2907
+++ +KLT+E+V+LA L F FYSF++LL+LT+ LL II+ +GP
Sbjct: 847 EAVPFANE-EKNKLTFEVVSLAHNLIYFGFYSFSELLRLTRTLLGIIDCVQGPP------ 899
Query: 2908 HRAMVNAI-----RNMSKSMMRGGNKENSKDLAKTPSV-----------TAEEAGRTK-- 3033
AM+ A +N+ +S+ G+ ++ L++ SV AE R+K
Sbjct: 900 --AMLQAYEDPGGKNVRRSIQGVGHMMSTMVLSRKQSVFSAPSLSAGASAAEPLDRSKFE 957
Query: 3034 EGRALNV-KTKLIVAEILQFVMDVRRDYRITMALSWFK----NVFPCDEDGS-------L 3177
E + V +TKL + EILQF+++VR DYRI+ LS FK VFP + G+
Sbjct: 958 ENEDIVVMETKLKILEILQFILNVRLDYRISYLLSVFKKEFVEVFPMQDSGADGTAPAFD 1017
Query: 3178 MHSASINERMASELYDAIY--RSSGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKV 3351
+A++N E +A++ + L +D G++ L +L+ +TM DY PL S AL++
Sbjct: 1018 STTANMNLDRIGEQAEAMFGVGKTSSMLEVDDEGGRMFLRVLIHLTMHDYAPLVSGALQL 1077
Query: 3352 FFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSID 3531
F+HF+Q QE + KQVQLL+S DVENY+ I +L L+ + EKSELWV D+ S
Sbjct: 1078 LFKHFSQRQEAMHTFKQVQLLISAQDVENYKVIKSELDRLRTMVEKSELWV--DKKGSGK 1135
Query: 3532 TKEV------DEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLL 3693
+EV D+KER T+ + H P S ++ + + +L
Sbjct: 1136 GEEVEAGTAKDKKERPTDEEGFLH----PPGEKSSENYQIVKGILE-------------- 1177
Query: 3694 NRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDPKPDTMNQQ-LLK 3870
RL MC G + QQ LLK
Sbjct: 1178 ------------------------------------RLNKMC---GVGEQMRKKQQRLLK 1198
Query: 3871 NMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAK 4050
NM ++V+L+ + +P+D K D MM+++ +H+FL+ FC N NQ+ L+K +
Sbjct: 1199 NMDAHKVMLDLLQIPYD-KGDAKMMEILRYTHQFLQKFCAGNPGNQALLHKHL--HLFLT 1255
Query: 4051 EGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCV 4230
G+L ET++ IF NN +L S + E ++ H V L+ + R+ +L+ L ++
Sbjct: 1256 PGLLEAETMQH------IFLNNYQLCSEISEPVLQHFVHLLATHGRHVQYLDFLHTVIKA 1309
Query: 4231 YDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYH 4410
K ++ Q+ + E+ A D+V Y D AS L MMK ++ + L YH
Sbjct: 1310 EGKYVKKCQDMIMTELTNAGDDVVVFYNDKASLAHLLDMMKAARD----GVEDHSPLMYH 1365
Query: 4411 IELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTD 4590
I LV LLA C GKN TE+KC S +P++ +V VVT + C+ EVK Y+ + HCY+DT+
Sbjct: 1366 ISLVDLLAACAEGKNVYTEIKCTSLVPLEDVVSVVTHEDCITEVKMAYVNFVNHCYVDTE 1425
Query: 4591 AEMKDAYKTEYVDHILNNLLEDIRSLRVEKLTGAETATLEHYICHTVTEVLIKFFEAPYS 4770
EMK+ Y + ++ + N D+ + ++ TLE Y+ V + + FF +P+S
Sbjct: 1426 VEMKEIYTSNHIWTLFENFTLDMARVCSKREKRVADPTLEKYVLSVVLDTINAFFSSPFS 1485
Query: 4771 ALQQAKVDVHHHKKTFSEV------LLELTYLEKGKLRGSKSSRNWYRVAECIKRLTKWA 4932
+ + H+ ++ LLE +L++ + +GS V CI+ L A
Sbjct: 1486 ---ENSTSLQTHQPVVVQLLQSTTRLLECPWLQQ-QHKGS--------VEACIRTLAMVA 1533
Query: 4933 EEHNITLPATL---AGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGHRLYGT 5103
+ I LP L +S S Q+ ASS K T R+ T
Sbjct: 1534 KGRAILLPMDLDAHISSMLSSGASCAAAAQRNASSYK-----------ATTRAFPRVTPT 1582
Query: 5104 SNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCA 5283
+N + N++ +I + L PL AE SVLV+VLH PELLF EGS +C
Sbjct: 1583 AN---QWDYKNIIEKLQDIITALEERLKPLVQAELSVLVDVLHWPELLFLEGSEAYQRCE 1639
Query: 5284 RGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKXXXXXXXXXXXXXXXXRYFGH 5463
GG ++KLIQH K LM++ ++ LC +VL+TL +M K Y
Sbjct: 1640 SGGFLSKLIQHTKDLMES-EEKLCIKVLRTLQQML-VKKTKYGDRGNQLRKMLLQNYL-- 1695
Query: 5464 HNNHHPPLDRQQSXXXXXXXXXXXXXXXTWSQERDLYAIQCKLNDAGASDLVTDIIIMEP 5643
+R+ + WS + A QC+L+ GA+ LV D+I
Sbjct: 1696 -------QNRKSTSRGDLPDPIGTGLDPDWSA---IAATQCRLDKEGATKLVCDLITSTK 1745
Query: 5644 SREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRLKSDM- 5820
+ +IF ++I LA LL GN ++Q SF+ M E FFK + R++ AQ KS +
Sbjct: 1746 NEKIFQESIGLAIHLLDGGNTEIQKSFHNLMMSDKKSERFFKVLHDRMKRAQQETKSTVA 1805
Query: 5821 --MSCSDSKPKVSLSATVSRRSSTVLTPLIDAGDTGFNGALFEVPQQVRHPSISEMSQLS 5994
M+ S+P V A F +P S+ +
Sbjct: 1806 VNMNDLGSQPHEDREPVDPTTKGRV--------------ASFSIPGSSSRYSLGPSLRRG 1851
Query: 5995 NDLTHSIPDLAPYQDEEKSTDALPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTN 6174
++++ + Q E T L +++PILR LQLLCENHN LQNFLR Q+++TN
Sbjct: 1852 HEVSERV------QSSEMGTSVL-----IMQPILRFLQLLCENHNRDLQNFLRCQNNKTN 1900
Query: 6175 HNLVSETLSFLDTVCGSTKGSLGVFG-EIGEHNFSLITQTLATLTEFCQGPCHENQNTMA 6351
+NLV ETL FLD +CGST G LG+ G I E N L+ QTL TLTE+CQGPCHENQ +
Sbjct: 1901 YNLVCETLQFLDIMCGSTTGGLGLLGLYINEDNVGLVIQTLETLTEYCQGPCHENQTCIV 1960
Query: 6352 MQE-NGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIMESRHDGENANRVLRNM 6528
E NG++II +L+LN+I PL M+L L++K ASKLLLA+MESRHD ENA R+L
Sbjct: 1961 THESNGIDIITALILNDISPLCKYRMDLVLQLKDNASKLLLALMESRHDSENAERIL--- 2017
Query: 6529 ANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPE 6708
+S P++LV IK+AY Q E+ + P+ + + +
Sbjct: 2018 --ISLRPQELVDVIKKAY------------------LQEEERENSEVSPREVGHNIYILA 2057
Query: 6709 INVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWL 6888
+ + H K + +++ ++ L++++ +L L
Sbjct: 2058 LQLSRHNKQLQHLLKPVKRIQEEEAEG-----------------ISSMLSLNNKQLSQML 2100
Query: 6889 DGSDEKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNT 7068
S +++ + L YY+ T+QIEIVR+DR++E++VFP+ IC +LT++TK ++ T
Sbjct: 2101 KSSAPAQEE-EEDPLAYYENHTSQIEIVRQDRSMEQIVFPVPGICQFLTEETKHRLFTTT 2159
Query: 7069 ERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALV 7248
E+D QGSKV++FFD+ +++EM WQR ++ + W + R+ LW +SF+ A +N ++
Sbjct: 2160 EQDEQGSKVSDFFDQSSFLHNEMEWQRNVRSMPLIYWFSRRMTLWGSISFNLAVFINIII 2219
Query: 7249 ARYYPLPEHSNSSI---SLGNLYSWFAVFSSFLLAHYLRHDKIYLHKTXXXXXXXXXXXX 7419
A +YP E +++ + L +L W + S R+ +
Sbjct: 2220 AFFYPYMEGASTGVLDSPLISLLFWILICFSIAALFTKRY-------SIRPLIVALILRS 2272
Query: 7420 XXXIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRNLHYLLVYLFICIL 7599
+G+ TL I G L L NKIV VV+FV N+G R ++ Y + Y+ +L
Sbjct: 2273 IYYLGIGPTLNILGALNLTNKIVFVVSFVGNRGTFIRGYKAMVMDMEFLYHVGYILTSVL 2332
Query: 7600 GLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALILLYFFSILGFLYFR 7779
GL H + Y ILLFD+I+ EETL NVI SVTRN +SI+ T LLALIL+Y FSI+GFL+ +
Sbjct: 2333 GLFAHELFYSILLFDLIYREETLFNVIKSVTRNGRSILLTALLALILVYLFSIVGFLFLK 2392
Query: 7780 HDFYLEVDPVENDSSATISSGIPS------ETCPSEGCP-----GLQPSXXXXXXXXXXX 7926
DF LEVD + N+ S G+P +TC + +
Sbjct: 2393 DDFILEVDRLPNNHSTASPLGMPHGAAAFVDTCSGDKMDCVSGLSVPEVLEEDRELDSTE 2452
Query: 7927 XSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTXXXXXXXXXXXXX 8106
+C+TL MCI+ GLRNGGG+GD+LR P+ E +F RV YD+
Sbjct: 2453 RACDTLLMCIVTVMNHGLRNGGGVGDILRKPSKDESLFPARVVYDLLFFFIVIIIVLNLI 2512
Query: 8107 XXXXXDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLYYI 8286
DTF DLR+EK +KE+ILK CFICGL+R +FDN++V+FE H + EHN+W+YLY+I
Sbjct: 2513 FGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKLEHNMWNYLYFI 2572
Query: 8287 VMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLLQM 8466
V++++K++T++TGPESYVAQ +K++NLDWFPRM+A+SL +E + +Q+E++ ++D+L
Sbjct: 2573 VLVRVKNKTDYTGPESYVAQMIKNKNLDWFPRMRAMSLVSNEGEGEQNEIRILQDKLNST 2632
Query: 8467 MTLMREIISQNEESRAFMEQFQPR 8538
M L+ + +Q E + M + + R
Sbjct: 2633 MKLVSHLTAQLNELKEQMTEQRKR 2656
>gi|17366458|sp|Q14573|IP3T_HUMAN Inositol 1,4,5-trisphosphate
receptor type 3 (Type 3 inositol 1,4,5-trisphosphate
receptor) (Type 3 InsP3 receptor) (IP3 receptor isoform
3) (InsP3R3)
gi|483831|dbj|BAA05385.1| type 3 inositol 1,4,5-trisphosphate
receptor [Homo sapiens]
Length = 2671
Score = 1580 bits (4091), Expect = 0.0
Identities = 1047/2902 (36%), Positives = 1548/2902 (53%), Gaps = 92/2902 (3%)
Frame = +1
Query: 109 LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
LHIGDI+SLY E S N GF+STLGLVDDRC+VE G ++PPKKFRDCLFKVCP+N
Sbjct: 8 LHIGDIVSLYAEGSVN----GFISTLGLVDDRCVVEPAAGDLDNPPKKFRDCLFKVCPMN 63
Query: 289 RYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQ 468
RY+AQK W ++ Q + + D L+ KL+ AA E+++N++E +K G+V++YGS++Q
Sbjct: 64 RYSAQKQYWKAKQTKQDKEKIADVVLLQKLQHAAQMEQKQNDTENKKVHGDVVKYGSVIQ 123
Query: 469 LLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKI 648
LLH+KSNKY+TV K PA E+NAM+V LD GNEGSW I+P +K + GDNV G+K+
Sbjct: 124 LLHMKSNKYLTVNKRLPALLEKNAMRVTLDATGNEGSWLFIQPFWKLRSNGDNVVVGDKV 183
Query: 649 SLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSV 828
L P AG LH S++ L D+ EVN +N T W++ +F+ F ++ + +
Sbjct: 184 ILNP-----VNAG---QPLHASNYELSDNAGCKEVNSVNCNTSWKINLFMQFRDHLEEVL 235
Query: 829 KSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTN 1008
K GDVVRLFHA+Q+ FLT D + VFLR T R SA ATSS ALWEV+VV +
Sbjct: 236 KGGDVVRLFHAEQEKFLTCDEYKGKLQ----VFLRTTLRQSATSATSSNALWEVEVVHHD 291
Query: 1009 AYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRRASLIYSKTNNPMAMYSDGP 1188
RGG WN YRFKHLAT YL+AE + A + + A M + G
Sbjct: 292 PCRGGAGHWNGLYRFKHLATGNYLAAEENPSYKGDASDPKAA-----------GMGAQGR 340
Query: 1189 NGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLL 1368
G N + I V P + D LF+LDP+T K++ VPR SYVRL
Sbjct: 341 TGRRNAG-----EKIKYCLVAVPHGN-----DIASLFELDPTTLQKTDSFVPRNSYVRLR 390
Query: 1369 HQSSDKWVHATNATEKQNLHYSSKNEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFA 1548
H ++ W+ +TN + + + C + DKE FA++ V E+RDLDFA
Sbjct: 391 HLCTNTWIQSTNVP----IDIEEERPIRLMLGTC-PTKEDKEAFAIVSVPVSEIRDLDFA 445
Query: 1549 NDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRD 1728
NDA L + ++ + G IS+ QLL D + FV++ ++ + L I P+R+
Sbjct: 446 NDASSMLASAVEKLNEG-FISQNDRRFVIQLLEDLVFFVSDVPNNGQNVLDIMVTKPNRE 504
Query: 1729 RQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIFKTMFQLCYCLL 1908
RQKL+REQ +L QVF +LKAPF + G D +N ++ MF+LCY +L
Sbjct: 505 RQKLMREQNILKQVFGILKAPFREKGG----EGPLVRLEELSDQKNAPYQHMFRLCYRVL 560
Query: 1909 KYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVE 2088
++SQ YRKNQE +A++FG +Q QIG+D++AEDT+TA+LHNN KLLEK++ VE FV
Sbjct: 561 RHSQEDYRKNQEHIAKQFGMMQSQIGYDILAEDTITALLHNNRKLLEKHITKTEVETFVS 620
Query: 2089 LVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKI---------- 2238
LVR NR+ +FLDYL+DLCV A QELIC VL K+ DI + T++
Sbjct: 621 LVRKNREPRFLDYLSDLCVSNHIAIPVTQELICKCVLDPKNSDILIRTELRPVKEMAQSH 680
Query: 2239 -------IDGEIEVGWAP-----NFRKLVDIAEGAKS-NSDDAEHLDYYRHQLDLLSQMC 2379
+ E+ + W + + + +A+ A++ N+ D L YYR+QL L ++MC
Sbjct: 681 EYLSIEYSEEEVWLTWTDKNNEHHEKSVRQLAQEARAGNAHDENVLSYYRYQLKLFARMC 740
Query: 2380 QEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLHLHVVRGSP- 2556
++QYLAID ISQQL +L+ CM+D LP+DLR SF LMLH+HV R
Sbjct: 741 LDRQYLAID--------EISQQLGVDLIFLCMADEMLPFDLRASFCHLMLHVHVDRDPQE 792
Query: 2557 -MSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATVETYLMGLRN 2733
++ ++ ARLW IP + + Y+S ++ A D + + + VE YL + +
Sbjct: 793 LVTPVKFARLWTEIPTAITIKDYDS-NLNASRDDKKNKFA-----NTMEFVEDYLNNVVS 846
Query: 2734 QSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIIN--EGPATEQVPS 2907
+++ +KLT+E+V+LA L F FYSF++LL+LT+ LL II+ +GP
Sbjct: 847 EAVPFANE-EKNKLTFEVVSLAHNLIYFGFYSFSELLRLTRTLLGIIDCVQGPP------ 899
Query: 2908 HRAMVNAI-----RNMSKSMMRGGNKENSKDLAKTPSV-----------TAEEAGRTK-- 3033
AM+ A +N+ +S+ G+ ++ L++ SV AE R+K
Sbjct: 900 --AMLQAYEDPGGKNVRRSIQGVGHMMSTMVLSRKQSVFSAPSLSAGASAAEPLDRSKFE 957
Query: 3034 EGRALNV-KTKLIVAEILQFVMDVRRDYRITMALSWFK----NVFPCDEDGS-------L 3177
E + V +TKL + EILQF+++VR DYRI+ LS FK VFP + G+
Sbjct: 958 ENEDIVVMETKLKILEILQFILNVRLDYRISHLLSVFKKEFVEVFPMQDSGADGTAPAFD 1017
Query: 3178 MHSASINERMASELYDAIY--RSSGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKV 3351
+A++N E +A++ + L +D G++ L +L+ +TM DY PL S AL++
Sbjct: 1018 STTANMNLDRIGEQAEAMFGVGKTSSMLEVDDEGGRMFLRVLIHLTMHDYAPLVSGALQL 1077
Query: 3352 FFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSID 3531
F+HF+Q QE + KQVQLL+S DVENY+ I +L L+ + EKSELWV D+ S
Sbjct: 1078 LFKHFSQRQEAMHTFKQVQLLISAQDVENYKVIKSELDRLRTMVEKSELWV--DKKGSGK 1135
Query: 3532 TKEV------DEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLL 3693
+EV D+KER T+ + H P S ++ + + +L
Sbjct: 1136 GEEVEAGAAKDKKERPTDEEGFLH----PPGEKSSENYQIVKGILE-------------- 1177
Query: 3694 NRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDPKPDTMNQQ-LLK 3870
RL MC G + QQ LLK
Sbjct: 1178 ------------------------------------RLNKMC---GVGEQMRKKQQRLLK 1198
Query: 3871 NMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAK 4050
NM ++V+L+ + +P+D K D MM+++ +H+FL+ FC N NQ+ L+K +
Sbjct: 1199 NMDAHKVMLDLLQIPYD-KGDAKMMEILRYTHQFLQKFCAGNPGNQALLHKHL--HLFLT 1255
Query: 4051 EGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCV 4230
G+L ET++ IF NN +L S + E ++ H V L+ + R+ +L+ L ++
Sbjct: 1256 PGLLEAETMQH------IFLNNYQLCSEISEPVLQHFVHLLATHGRHVQYLDFLHTVIKA 1309
Query: 4231 YDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYH 4410
K ++ Q+ + E+ A D+V Y D AS L MMK ++ + L YH
Sbjct: 1310 EGKYVKKCQDMIMTELTNAGDDVVVFYNDKASLAHLLDMMKAARD----GVEDHSPLMYH 1365
Query: 4411 IELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTD 4590
I LV LLA C GKN TE+KC S +P++ +V VVT + C+ EVK Y+ + HCY+DT+
Sbjct: 1366 ISLVDLLAACAEGKNVYTEIKCTSLLPLEDVVSVVTHEDCITEVKMAYVNFVNHCYVDTE 1425
Query: 4591 AEMKDAYKTEYVDHILNNLLEDIRSLRVEKLTGAETATLEHYICHTVTEVLIKFFEAPYS 4770
EMK+ Y + ++ + N D+ + ++ TLE Y+ V + + FF +P+S
Sbjct: 1426 VEMKEIYTSNHIWTLFENFTLDMARVCSKREKRVADPTLEKYVLSVVLDTINAFFSSPFS 1485
Query: 4771 ----ALQQAKVDVHHHKKTFSEVLLELTYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEE 4938
+LQ + V ++ + LLE +L++ + +GS V CI+ L A+
Sbjct: 1486 ENSTSLQTHQTIVVQLLQSTTR-LLECPWLQQ-QHKGS--------VEACIRTLAMVAKG 1535
Query: 4939 HNITLPATL---AGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGHRLYGTSN 5109
I LP L +S S Q+ ASS K T R+ T+N
Sbjct: 1536 RAILLPMDLDAHISSMLSSGASCAAAAQRNASSYK-----------ATTRAFPRVTPTAN 1584
Query: 5110 SMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCARG 5289
+ N++ +I + L PL AE SVLV+VLH PELLF EGS +C G
Sbjct: 1585 ---QWDYKNIIEKLQDIITALEERLKPLVQAELSVLVDVLHWPELLFLEGSEAYQRCESG 1641
Query: 5290 GVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKXXXXXXXXXXXXXXXXRYFGHHN 5469
G ++KLIQH K LM++ ++ LC +VL+TL +M K Y
Sbjct: 1642 GFLSKLIQHTKDLMES-EEKLCIKVLRTLQQML-LKKTKYGDRGNQLRKMLLQNYL---- 1695
Query: 5470 NHHPPLDRQQSXXXXXXXXXXXXXXXTWSQERDLYAIQCKLNDAGASDLVTDIIIMEPSR 5649
+R+ + WS + A QC+L+ GA+ LV D+I +
Sbjct: 1696 -----QNRKSTSRGDLPDPIGTGLDPDWSA---IAATQCRLDKEGATKLVCDLITSTKNE 1747
Query: 5650 EIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRLKSDM--- 5820
+IF ++I LA LL GN ++Q SF+ M E FFK + R++ AQ KS +
Sbjct: 1748 KIFQESIGLAIHLLDGGNTEIQKSFHNLMMSDKKSERFFKVLHDRMKRAQQETKSTVAVN 1807
Query: 5821 MSCSDSKPKVSLSATVSRRSSTVLTPLIDAGDTGFNGALFEVPQQVRHPSISEMSQLSND 6000
M+ S+P V A F +P S+ + ++
Sbjct: 1808 MNDLGSQPHEDREPVDPTTKGRV--------------ASFSIPGSSSRYSLGPSLRRGHE 1853
Query: 6001 LTHSIPDLAPYQDEEKSTDALPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHN 6180
++ + Q E T L +++PILR LQLLCENHN LQNFLR Q+++TN+N
Sbjct: 1854 VSERV------QSSEMGTSVL-----IMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYN 1902
Query: 6181 LVSETLSFLDTVCGSTKGSLGVFG-EIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQ 6357
LV ETL FLD +CGST G LG+ G I E N L+ QTL TLTE+CQGPCHENQ +
Sbjct: 1903 LVCETLQFLDIMCGSTTGGLGLLGLYINEDNVGLVIQTLETLTEYCQGPCHENQTCIVTH 1962
Query: 6358 E-NGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIMESRHDGENANRVLRNMAN 6534
E NG++II +L+LN+I PL M+L L++K ASKLLLA+MESRHD ENA R+L
Sbjct: 1963 ESNGIDIITALILNDISPLCKYRMDLVLQLKDNASKLLLALMESRHDSENAERIL----- 2017
Query: 6535 MSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEIN 6714
+S P++LV IK+AY Q E+ + P+ + + + +
Sbjct: 2018 ISLRPQELVDVIKKAY------------------LQEEERENSEVSPREVGHNIYILALQ 2059
Query: 6715 VDASGIVSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLDG 6894
+ H K + +++ ++ L++++ +L L
Sbjct: 2060 LSRHNKQLQHLLKPVKRIQEEEAEG-----------------ISSMLSLNNKQLSQMLKS 2102
Query: 6895 SDEKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTER 7074
S +++ + L YY+ T+QIEIVR+DR++E++VFP+ IC +LT++TK ++ TE+
Sbjct: 2103 SAPAQEE-EEDPLAYYENHTSQIEIVRQDRSMEQIVFPVPGICQFLTEETKHRLFTTTEQ 2161
Query: 7075 DNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVAR 7254
D QGSKV++FFD+ +++EM WQR ++ + W + R+ LW +SF+ A +N ++A
Sbjct: 2162 DEQGSKVSDFFDQSSFLHNEMEWQRNVRSMPLIYWFSRRMTLWGSISFNLAVFINIIIAF 2221
Query: 7255 YYPLPEHSNSSI---SLGNLYSWFAVFSSFLLAHYLRHDKIYLHKTXXXXXXXXXXXXXX 7425
+YP E +++ + L +L W + S R+ +
Sbjct: 2222 FYPYMEGASTGVLDSPLISLLFWILICFSIAALFTKRY-------SIRPLIVALILRSIY 2274
Query: 7426 XIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRNLHYLLVYLFICILGL 7605
+G+ TL I G L L NKIV VV+FV N+G R ++ Y + Y+ +LGL
Sbjct: 2275 YLGIGPTLNILGALNLTNKIVFVVSFVGNRGTFIRGYKAMVMDMEFLYHVGYILTSVLGL 2334
Query: 7606 LVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHD 7785
H + Y ILLFD+I+ EETL NVI SVTRN +SI+ T LLALIL+Y FSI+GFL+ + D
Sbjct: 2335 FAHELFYSILLFDLIYREETLFNVIKSVTRNGRSILLTALLALILVYLFSIVGFLFLKDD 2394
Query: 7786 FYLEVDPVENDSSATISSGIPS------ETCPSEGCP-----GLQPSXXXXXXXXXXXXS 7932
F LEVD + N+ S G+P +TC + + +
Sbjct: 2395 FILEVDRLPNNHSTASPLGMPHGAAAFVDTCSGDKMDCVSGVSVPEVLEEDRELDSTERA 2454
Query: 7933 CETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTXXXXXXXXXXXXXXX 8112
C+TL MCI+ GLRNGGG+GD+LR P+ E +F RV YD+
Sbjct: 2455 CDTLLMCIVTVMNHGLRNGGGVGDILRKPSKDESLFPARVVYDLLFFFIVIIIVLNLIFG 2514
Query: 8113 XXXDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLYYIVM 8292
DTF DLR+EK +KE+ILK CFICGL+R +FDN++V+FE H + EHN+W+YLY+IV+
Sbjct: 2515 VIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKLEHNMWNYLYFIVL 2574
Query: 8293 LQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLLQMMT 8472
+++K++T++TGPESYVAQ +K++NLDWFPRM+A+SL +E + +Q+E++ ++D+L M
Sbjct: 2575 VRVKNKTDYTGPESYVAQMIKNKNLDWFPRMRAMSLVSNEGEGEQNEIRILQDKLNSTMK 2634
Query: 8473 LMREIISQNEESRAFMEQFQPR 8538
L+ + +Q E + M + + R
Sbjct: 2635 LVSHLTAQLNELKEQMTEQRKR 2656
>gi|6981110|ref|NP_037270.1| inositol 1, 4, 5-triphosphate receptor 3
[Rattus norvegicus]
gi|17365979|sp|Q63269|IP3T_RAT Inositol 1,4,5-trisphosphate receptor
type 3 (Type 3 inositol 1,4,5-trisphosphate receptor)
(Type 3 InsP3 receptor) (IP3 receptor isoform 3)
(InsP3R3) (IP3R-3)
gi|423895|pir||A46719 inositol 1,4,5-trisphosphate receptor subtype 3
- rat
gi|310171|gb|AAA41446.1| inositol triphosphate receptor subtype 3
Length = 2670
Score = 1575 bits (4079), Expect = 0.0
Identities = 1042/2906 (35%), Positives = 1548/2906 (52%), Gaps = 96/2906 (3%)
Frame = +1
Query: 109 LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
LHIGDI+SLY E S N GF+STLGLVDDRC+VE G ++PPKKFRDCLFKVCP+N
Sbjct: 8 LHIGDIVSLYAEGSVN----GFISTLGLVDDRCVVEPAAGDLDNPPKKFRDCLFKVCPMN 63
Query: 289 RYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQ 468
RY+AQK W ++ Q + + D L+ KL+ AA E+++N++E +K G+V++YGS++Q
Sbjct: 64 RYSAQKQYWKAKQTKQDKEKIADVVLLQKLQHAAQMEQKQNDTENKKVHGDVVKYGSVIQ 123
Query: 469 LLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKI 648
LLH+KSNKY+TV K PA E+NAM+V LD GNEGSW I+P +K + GDNV G+K+
Sbjct: 124 LLHMKSNKYLTVNKRLPALLEKNAMRVTLDATGNEGSWLFIQPFWKLRSNGDNVVVGDKV 183
Query: 649 SLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSV 828
L P AG LH S++ L D+ EVN +N T W++ +F+ F ++ + +
Sbjct: 184 ILNP-----VNAG---QPLHASNYELSDNVGCKEVNSVNCNTSWKINLFMQFRDHLEEVL 235
Query: 829 KSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTN 1008
K GDVVRLFHA+Q+ FLT D + VFLR T R SA ATSS ALWEV+VV +
Sbjct: 236 KGGDVVRLFHAEQEKFLTCDEYRGKLQ----VFLRTTLRQSATSATSSNALWEVEVVHHD 291
Query: 1009 AYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRRASLIYSKTNNPMAMYSDGP 1188
RGG WN YRFKHLAT YL+AE + P+ G ++P A GP
Sbjct: 292 PCRGGAGHWNGLYRFKHLATGNYLAAEEN-----PSYKG--------DVSDPKAA---GP 335
Query: 1189 NGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLL 1368
+ + I V P + D LF+LDP+T K++ VPR SYVRL
Sbjct: 336 GAQSRTGRRNAGEKIKYRLVAVPHGN-----DIASLFELDPTTLQKTDSFVPRNSYVRLR 390
Query: 1369 HQSSDKWVHATNATEKQNLHYSSKNEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFA 1548
H ++ W+ +TNA + + + C + DKE FA++ V E+RDLDFA
Sbjct: 391 HLCTNTWIQSTNAP----IDVEEERPIRLMLGTC-PTKEDKEAFAIVSVPVSEIRDLDFA 445
Query: 1549 NDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRD 1728
NDA L + ++ + G IS+ QLL D + FV++ ++ + L I P+R+
Sbjct: 446 NDASSMLASAVEKLNEG-FISQNDRRFVIQLLEDLVFFVSDVPNNGQNVLDIMVTKPNRE 504
Query: 1729 RQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIFKTMFQLCYCLL 1908
RQKL+R++ +L Q+F +LKAPF + G D +N ++ MF+LCY +L
Sbjct: 505 RQKLMRDENILKQIFGILKAPFRDKGG----EGPLVRLEELSDQKNAPYQYMFRLCYRVL 560
Query: 1909 KYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVE 2088
++SQ YRKNQE +A++FG +Q QIG+D++AEDT+TA+LHNN KLLEK++ VE FV
Sbjct: 561 RHSQEDYRKNQEHIAKQFGMMQSQIGYDILAEDTITALLHNNRKLLEKHITKTEVETFVS 620
Query: 2089 LVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKI---------- 2238
LVR NR+ +FLDYL+DLCV A QELIC VL K+ DI + T++
Sbjct: 621 LVRKNREPRFLDYLSDLCVSNRIAIPVTQELICKCVLDPKNSDILIQTELRPVKEMAQSH 680
Query: 2239 -------IDGEIEVGWAP-----NFRKLVDIAEGAKS-NSDDAEHLDYYRHQLDLLSQMC 2379
+ E+ + W + + + +A+ A++ N+ D L YYR+QL L ++MC
Sbjct: 681 EYLSIEYSEEEVWLTWTDRNNEHHEKSVRQLAQEARAGNAHDENVLSYYRYQLKLFARMC 740
Query: 2380 QEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLHLHVVRGSP- 2556
++QYLAID IS+QL EL+ CM+D LP+DLR SF LMLH+HV R
Sbjct: 741 LDRQYLAID--------EISKQLGVELLFLCMADEMLPFDLRASFCHLMLHVHVDRDPQE 792
Query: 2557 -MSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATVETYLMGLRN 2733
++ ++ ARLW IP + + Y+S ++ A D + +K +T+E L N
Sbjct: 793 LVTPVKFARLWTEIPTAITIKDYDS-NLNASRDDKK--------NKFASTMEFVEDYLNN 843
Query: 2734 QSMEERQSVNSSK--LTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINEGPATEQVPS 2907
E N K LT+E+V+LA L F FYSF++LL+LT+ LL II + + +
Sbjct: 844 VVGEAVPFANDEKNILTFEVVSLAHNLIYFGFYSFSELLRLTRTLLGII------DCIQA 897
Query: 2908 HRAMVNAI-----RNMSKSMMRGGNKENSKDLAKTPSV-----------TAEEAGRTK-- 3033
A++ A +N+ +S+ G+ ++ L++ SV E+ R+K
Sbjct: 898 PAAVLQAYEEPGGKNVRRSIQGVGHMMSTMVLSRKQSVFGASSLPTGVGVPEQLDRSKFE 957
Query: 3034 -EGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFK----NVFPCDEDGS-------L 3177
+ ++TKL + EILQF+++VR DYRI+ LS FK VFP + G+
Sbjct: 958 DNEHTVVMETKLKILEILQFILNVRLDYRISYLLSVFKKEFVEVFPMQDSGADGTAPAFD 1017
Query: 3178 MHSASINERMASELYDAIY--RSSGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKV 3351
+A++N E +A++ + L +D G++ L +LL +TM DYPPL S AL++
Sbjct: 1018 SSTANMNLDRIGEQAEAMFGVGKTSSMLEVDDEGGRMFLRVLLHLTMHDYPPLVSGALQL 1077
Query: 3352 FFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSID 3531
F+HF+Q QE + KQVQLL+S DVENY+ I +L L+ + EKSELWV D+ S+
Sbjct: 1078 LFKHFSQRQEAMHTFKQVQLLISAQDVENYKVIKSELDRLRTMVEKSELWV--DKKGSVK 1135
Query: 3532 TKE------VDEKERTTEHD--LLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQ 3687
+E D+KER ++ + L H KS +E+Y ++
Sbjct: 1136 GEEGEAGASKDKKERPSDEEGFLQPHGEKS-----------------SENYQIVKG---- 1174
Query: 3688 LLNRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDPKPDTMNQQLL 3867
+L RL MC + Q+LL
Sbjct: 1175 -----------------------------------ILERLNKMC--GVGEQMRKKQQRLL 1197
Query: 3868 KNMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDA 4047
KNM ++V+L+ + +P+D K+D+ MM+++ +H+FL+ FC N NQ+ L+K + +
Sbjct: 1198 KNMDAHKVMLDLLQIPYD-KNDNKMMEILRYTHQFLQKFCAGNPGNQALLHKHL--QLFL 1254
Query: 4048 KEGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVC 4227
G+L ET++ IF NN +L S + E ++ H V + R+ +L+ L ++
Sbjct: 1255 TPGLLEAETMQH------IFLNNYQLCSEISEPVLQHFVHCWPTHGRHVQYLDFLHTVIK 1308
Query: 4228 VYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKY 4407
K ++ Q+ + E+ A D+V Y D AS L MMK ++ + L Y
Sbjct: 1309 AEGKYVKKCQDMIMTELTNAGDDVVVFYNDKASLAHLLDMMKAARD----GVEDHSPLMY 1364
Query: 4408 HIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDT 4587
HI LV LLA C GKN TE+KC S +P++ +V VVT + C+ EVK Y+ + HCY+DT
Sbjct: 1365 HISLVDLLAACAEGKNVYTEIKCTSLLPLEDVVSVVTHEDCITEVKMAYVNFVNHCYVDT 1424
Query: 4588 DAEMKDAYKTEYVDHILNNLLEDIRSLRVEKLTGAETATLEHYICHTVTEVLIKFFEAPY 4767
+ EMK+ Y + ++ + N D+ + ++ TLE Y+ V + + FF +P+
Sbjct: 1425 EVEMKEIYTSNHIWTLFENFTLDMALVCNKREKRLSDPTLEKYVLTVVLDTISAFFSSPF 1484
Query: 4768 S----ALQQAKVDVHHHKKTFSEVLLELTYLEKGKLRGSKSSRNWYRVAECIKRLTKWAE 4935
S +LQ + V ++ + LLE +L++ + +GS V C++ L A+
Sbjct: 1485 SENSTSLQTHQTIVVQLLQSTTR-LLECPWLQQ-QHKGS--------VEACVRTLAMVAK 1534
Query: 4936 EHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSM 5115
I LP L MS S AA + N + R+ T+N
Sbjct: 1535 SRAILLPMDL-DAHMSALLSSGGSCSAAAQRS-------AANYKTATRTFPRVIPTAN-- 1584
Query: 5116 TEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCARGGV 5295
+ N++ +I + L PL AE SVLV++LH PELLF EGS +C GG
Sbjct: 1585 -QWDYKNIIEKLQDIITALEERLKPLVQAELSVLVDMLHWPELLFLEGSEAYQRCESGGF 1643
Query: 5296 VAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKXXXXXXXXXXXXXXXXRYFGHHNNH 5475
++KLI+H K LM++ ++ LC +VL+TL +M K Y
Sbjct: 1644 LSKLIRHTKGLMES-EEKLCVKVLRTLQQMLQ-KKSKYGDRGNQLRKMLLQNYL------ 1695
Query: 5476 HPPLDRQQSXXXXXXXXXXXXXXXTWSQERDLYAIQCKLNDAGASDLVTDIIIMEPSREI 5655
+R+ WS + A QC+L+ GA+ LV D+I + +I
Sbjct: 1696 ---QNRKSGPRGELTDPTGSGVDQDWSA---IAATQCRLDKEGATKLVCDLITSTKNEKI 1749
Query: 5656 FLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRLKSDMMSCSD 5835
F ++I LA LL GN ++Q SFY M E FFK + R++ AQ K
Sbjct: 1750 FQESIGLAIRLLDGGNTEIQKSFYNLMTSDKKSERFFKVLHDRMKRAQQETK-------- 1801
Query: 5836 SKPKVSLSATVSRRSSTVLTPLIDAGDTGFNGALFEVPQQVRHPS-------ISEMSQLS 5994
STV + D G P++ R P+ +S S S
Sbjct: 1802 ---------------STVAVNMSDLGSQ---------PREDREPADPTTKGRVSSFSMPS 1837
Query: 5995 NDLTHSIPDLAPYQD--EEKSTDALPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDR 6168
+ P L D E + + V ++ PILR LQLLCENHN LQNFLR Q+++
Sbjct: 1838 SSRYSLGPGLHRGHDVSERAQNNEMGTSVLIMRPILRFLQLLCENHNRDLQNFLRCQNNK 1897
Query: 6169 TNHNLVSETLSFLDTVCGSTKGSLGVFG-EIGEHNFSLITQTLATLTEFCQGPCHENQNT 6345
TN+NLV ETL FLD +CGST G LG+ G I E N L+ QTL TLTE+CQGPCHENQ
Sbjct: 1898 TNYNLVCETLQFLDIMCGSTTGGLGLLGLYINEDNVGLVIQTLETLTEYCQGPCHENQTC 1957
Query: 6346 MAMQE-NGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIMESRHDGENANRVLR 6522
+ E NG++II +L+LN+I PL M+L L++K ASKLLLA+MESRHD ENA R+L
Sbjct: 1958 IVTHESNGIDIITALILNDISPLCKYRMDLVLQLKDNASKLLLALMESRHDSENAERIL- 2016
Query: 6523 NMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLKKKSGPQITVNTVTL 6702
+S P++LV IK+AY Q E+ + P+ + + +
Sbjct: 2017 ----ISLRPQELVDVIKKAY------------------LQEEERENSEVSPREVGHNIYI 2054
Query: 6703 PEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNIYILAHQLAIHDGELEI 6882
+ + H K + +++ ++ L++++ +L
Sbjct: 2055 LALQLSRHNKQLQHLLKPVKRIQEEEAEG-----------------ISSMLSLNNKQLSQ 2097
Query: 6883 WLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPINDICSYLTKDTKDYVYN 7062
L S +++ + L YY+ T+QIEIVR+DR++E++VFP+ IC +LT++TK ++
Sbjct: 2098 MLKSSAPAQEE-EEDPLAYYENHTSQIEIVRQDRSMEQIVFPVPAICQFLTEETKHRLFT 2156
Query: 7063 NTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNA 7242
TE+D QGSKV++FFD+ +++EM WQR+L+ + W + R+ LW +SF+ A +N
Sbjct: 2157 TTEQDEQGSKVSDFFDQSSFLHNEMEWQRRLRSMPLIYWFSRRMTLWGSISFNLAVFINI 2216
Query: 7243 LVARYYPLPEHSNSSI---SLGNLYSWFAVFSSFLLAHYLRHDKIYLHKTXXXXXXXXXX 7413
++A +YP E +++ + L +L W + S + A + +H +
Sbjct: 2217 IIAFFYPYVEGASTGVLGSPLISLLFWILICFS-IAALFTKHYSV------RPLIVALVL 2269
Query: 7414 XXXXXIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRNLHYLLVYLFIC 7593
+G+ TL I G L L NKIV VV+FV N+G R ++ Y + Y+
Sbjct: 2270 RSIYYLGIGPTLNILGALNLTNKIVFVVSFVGNRGTFIRGYKAMVMDMEFLYHVGYILTS 2329
Query: 7594 ILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALILLYFFSILGFLY 7773
+LGL H + Y ILLFD+I+ EETL NVI SVTRN +SI+ T LLALIL+Y FSI+GFL+
Sbjct: 2330 VLGLFAHELFYSILLFDLIYREETLFNVIKSVTRNGRSILLTALLALILVYLFSIVGFLF 2389
Query: 7774 FRHDFYLEVDPVENDSSATISSGIPSETCPSEG-CPG----------LQPSXXXXXXXXX 7920
+ DF LEVD + + S + G+P G C G +
Sbjct: 2390 LKDDFILEVDRLPGNHSRASTLGMPHGAATFMGTCSGDKMDCVSEVSVPEILEEDEELDS 2449
Query: 7921 XXXSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTXXXXXXXXXXX 8100
+C+TL MCI+ GLRNGGG+GD+LR P+ E +F RV YD+
Sbjct: 2450 TERACDTLLMCIVTVMNHGLRNGGGVGDILRKPSKDESLFPARVVYDLLFFFIVIIIVLN 2509
Query: 8101 XXXXXXXDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLY 8280
DTF DLR+EK +KE+ILK CFICGL+R +FDN++V+FE H + EHN+W+YLY
Sbjct: 2510 LIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKLEHNMWNYLY 2569
Query: 8281 YIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLL 8460
+IV++++K++T++TGPESYVAQ +K++NLDWFPRM+A+SL E + +Q+E++ ++++L
Sbjct: 2570 FIVLVRVKNKTDYTGPESYVAQMIKNKNLDWFPRMRAMSLVSGEGEGEQNEIRILQEKLG 2629
Query: 8461 QMMTLMREIISQNEESRAFMEQFQPR 8538
M L+ + +Q E + M + + R
Sbjct: 2630 STMKLVSHLTAQLNELKEQMTEQRKR 2655
>gi|27805963|ref|NP_776795.1| inositol 1,4,5-triphosphate receptor,
type 3 [Bos taurus]
gi|17432548|gb|AAL39078.1| inositol 1,4,5-trisphosphate receptor type
3 [Bos taurus]
Length = 2664
Score = 1570 bits (4065), Expect = 0.0
Identities = 1040/2897 (35%), Positives = 1539/2897 (52%), Gaps = 87/2897 (3%)
Frame = +1
Query: 109 LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
LHIGDI+SLY E S N GF+STLGLVDDRC+VE G ++PPKKFRDCLFKVCP+N
Sbjct: 8 LHIGDIVSLYAEGSVN----GFISTLGLVDDRCVVEPAAGDLDNPPKKFRDCLFKVCPMN 63
Query: 289 RYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQ 468
RY+AQK W ++ Q + + D L+ KL+ AA E+++N++E +K G+V++YGS++Q
Sbjct: 64 RYSAQKQYWKAKQTKQDKEKIADVVLLQKLQHAAQMEQKQNDTENKKVHGDVVKYGSVIQ 123
Query: 469 LLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKI 648
LLH+KSNKY+TV K PA E+NAM+V LD GNEGSW I+P +K + GDNV G+K+
Sbjct: 124 LLHMKSNKYLTVNKRLPALLEKNAMRVTLDATGNEGSWLFIQPFWKLRSNGDNVVVGDKV 183
Query: 649 SLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSV 828
L P AG LH S++ L D+ EVN +N T W++ +F+ F ++ + +
Sbjct: 184 ILNP-----VNAGQ---PLHASNYELSDNAGCKEVNSVNCNTSWKINLFMQFRDHLEEVL 235
Query: 829 KSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTN 1008
K GDVVRLFHA+Q+ FLT D + VFLR T R SA ATSS ALWEV+VV +
Sbjct: 236 KGGDVVRLFHAEQEKFLTCDEYRGKLQ----VFLRTTLRQSATSATSSNALWEVEVVHHD 291
Query: 1009 AYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRRASLIYSKTNNPMAMYSDGP 1188
RGG WN YRFKHLAT YL+AE + P+ G ++P A G
Sbjct: 292 PCRGGAGHWNGLYRFKHLATGNYLAAEEN-----PSYKG--------DASDPKAA-GTGA 337
Query: 1189 NGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLL 1368
G T + I V P ++ LF+LDP+T K++ VPR SYVRL
Sbjct: 338 QGRTGRRN--AGEKIKYRLVAVPHGNDIAS-----LFELDPTTLQKTDSFVPRNSYVRLR 390
Query: 1369 HQSSDKWVHATNATEKQNLHYSSKNEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFA 1548
H ++ W+ +TN + + + C + DKE FA++ V E+RDLDFA
Sbjct: 391 HLCTNTWIQSTNVP----IDVEEERPIRLMLGTCP-TKEDKEAFAIVSVPVSEIRDLDFA 445
Query: 1549 NDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRD 1728
NDA L + ++ + G IS+ QLL D + FV++ ++ + L I P+R+
Sbjct: 446 NDASSMLASAVEKLHEG-FISQNDRRFVIQLLEDLVFFVSDVPNNGQNVLDIMVTKPNRE 504
Query: 1729 RQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIFKTMFQLCYCLL 1908
RQKL+REQ +L Q+F +LKAPF + G D +N ++ MF+LCY +L
Sbjct: 505 RQKLMREQNILKQIFGILKAPFRDKGGE----GPLVRLEELSDQKNAPYQHMFRLCYRVL 560
Query: 1909 KYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVE 2088
++SQ YRKNQE +A++FG +Q QIG+D++AEDT+TA+LHNN KLLEK++ VE FV
Sbjct: 561 RHSQEDYRKNQEHIAKQFGMMQSQIGYDILAEDTITALLHNNRKLLEKHITKTEVETFVS 620
Query: 2089 LVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKI---------- 2238
LVR NR+ +FLDYL+DLCV A QELIC VL K+ DI + T++
Sbjct: 621 LVRKNREPRFLDYLSDLCVSNHIAIPVTQELICKCVLDPKNSDILIQTELRPVKEMAQSH 680
Query: 2239 -------IDGEIEVGWAP-----NFRKLVDIAEGAKS-NSDDAEHLDYYRHQLDLLSQMC 2379
+ E+ + W + + + +A+ A++ N+ D L YYR+QL L ++MC
Sbjct: 681 EYLSIEYSEEEVWLTWTDKNNEHHEKSVRQLAQEARAGNAHDENVLSYYRYQLKLFARMC 740
Query: 2380 QEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLHLHVVRGSP- 2556
++QYLAID ISQQL +L+ CM+D LP+DLR SF LMLH+HV R
Sbjct: 741 LDRQYLAID--------EISQQLGVDLIFLCMADEMLPFDLRASFCHLMLHVHVDRDPQE 792
Query: 2557 -MSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATVETYLMGLRN 2733
++ ++ ARLW IP + + Y+S ++ A D + + + VE YL + +
Sbjct: 793 LVTPVKFARLWTEIPTAITIKDYDS-NLNASRDDKKNKFA-----STMEFVEDYLNNVVS 846
Query: 2734 QSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIIN-----EGPATEQ 2898
+++ +KLT+E+V+LA L F FYSF++LL+LT+ LL II+ E P +
Sbjct: 847 EAVPFANE-EKNKLTFEVVSLAHNLIYFGFYSFSELLRLTRTLLGIIDCVQAYEDPGGKN 905
Query: 2899 VPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAE-------EAGRTKEGRALNV- 3054
V R + +M +M+ N++ S + PS+ A + + +E + V
Sbjct: 906 V---RRSTQGVGHMMSTMVL--NRKQS--VFGGPSLPAGAGAPEPLDGSKFEENEDIVVM 958
Query: 3055 KTKLIVAEILQFVMDVRRDYRITMALSWFK----NVFPCDEDGS-------LMHSASINE 3201
+TKL + EILQF+++VR DYRI+ LS FK VFP + G+ +A++N
Sbjct: 959 ETKLKILEILQFILNVRLDYRISYLLSVFKKEFVEVFPMQDSGADGTAPAFDSTTANMNL 1018
Query: 3202 RMASELYDAIY--RSSGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQY 3375
E +A++ + L +D G++LL +L+ +TM DY PL S AL++ F+HF+Q
Sbjct: 1019 DRIGEQAEAMFGVGKTSSMLEVDDEGGRMLLRVLIHLTMHDYAPLVSGALQLLFKHFSQR 1078
Query: 3376 QELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWV------HGDRHHSIDTK 3537
QE++ KQVQLL+S DVENY+ I +L L+ + EKSELWV G+ + K
Sbjct: 1079 QEVMHTFKQVQLLISAQDVENYKVIKSELDRLRTMVEKSELWVDKKGASKGEEGEAGPAK 1138
Query: 3538 EVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDD 3717
D+KER T+ + H P S ++ + + +L
Sbjct: 1139 --DKKERPTDEEGFLH----PPGEKSSENYQIVKGILE---------------------- 1170
Query: 3718 RNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDPKPDTMNQQ-LLKNMRVYEVV 3894
RL MC G + QQ LLKNM ++V+
Sbjct: 1171 ----------------------------RLNKMC---GVGEQMRKKQQRLLKNMDAHKVM 1199
Query: 3895 LEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVET 4074
L+ + +P+D K D MM+++ +H+FL+ FC N NQ+ L+K + G+L ET
Sbjct: 1200 LDLLQIPYD-KGDAKMMEILRYTHQFLQKFCAGNPGNQALLHKHL--HLFLTPGLLEAET 1256
Query: 4075 IEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESG 4254
++ IF NN +L S + E ++ H V L+ + + +L+ L ++ K ++
Sbjct: 1257 MQH------IFLNNYQLCSEIGEPVLQHFVHLLATHGHHVQYLDFLHTVIKAEGKYVKKC 1310
Query: 4255 QEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLA 4434
Q+ + E A D+V Y D AS L MMK ++ + L YHI LV LLA
Sbjct: 1311 QDMIMTEPANAGDDVVVFYNDKASLAHLLDMMKAARD----GVEDHSPLMYHISLVDLLA 1366
Query: 4435 MCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYK 4614
C GKN TE+KC S +P++ +V VVT + C+ EVK Y+ + HCY+DT+ EMK+ Y
Sbjct: 1367 ACAEGKNVYTEIKCTSLLPLEDVVSVVTHEDCITEVKMAYVNFVNHCYVDTEVEMKEIYT 1426
Query: 4615 TEYVDHILNNLLEDIRSLRVEKLTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVD 4794
+ ++ + N D+ + ++ LE Y+ V + + FF +P+S +
Sbjct: 1427 SNHIWTLFENFTLDMARVCSKREKRLADPALEKYVLTVVLDTISAFFSSPFS---ENSTS 1483
Query: 4795 VHHHKKTFSEV------LLELTYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNITLP 4956
+ H+ ++ LLE +L++ + +GS V CI+ L A+ I+LP
Sbjct: 1484 LQTHQTIVVQLLQSTMRLLECPWLQQ-QHKGS--------VEACIRTLAMVAKGRAISLP 1534
Query: 4957 ----ATLAGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEH 5124
A ++ SG + V + A+ N + R+ T+N +
Sbjct: 1535 MDLDAHISSLLSSGASCVAAAQRNAS------------NYKTATRAFPRVMPTAN---QW 1579
Query: 5125 TSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAK 5304
N++ +I + L PL AE SVLV+VLH PELLF EGS +C GG ++K
Sbjct: 1580 DYKNIIEKLQDIITALEERLRPLVQAELSVLVDVLHWPELLFLEGSDAYQRCESGGFLSK 1639
Query: 5305 LIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKXXXXXXXXXXXXXXXXRYFGHHNNHHPP 5484
LIQH K LM++ ++ LC +VL+TL +M K Y
Sbjct: 1640 LIQHTKDLMES-EEKLCVKVLRTLQQML-LKKTKYGDRGNQLRKMLLQNYL--------- 1688
Query: 5485 LDRQQSXXXXXXXXXXXXXXXTWSQERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLK 5664
+R+ S WS + A QC+L+ GA+ LV D+I + +IF +
Sbjct: 1689 QNRKSSSRGDLPDPMGTGLDQDWSA---IAATQCRLDKEGATKLVCDLITSTKNEKIFQE 1745
Query: 5665 AIHLARALLHEGNDKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRLKSDM---MSCSD 5835
+I LA LL GN ++Q SFY M E FFK + R++ AQ KS + MS
Sbjct: 1746 SIGLAIRLLDGGNTEIQKSFYNLMTSDKKSERFFKVLHDRMKRAQQETKSTVAVNMSDLG 1805
Query: 5836 SKPKVSLSATVSRRSSTVLTPLIDAGDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSI 6015
S+P+ V A F +P ++ + +++ +
Sbjct: 1806 SQPREDREQADPTSKGRV--------------ASFSMPSSSSRYALGPSLRRGHEVGERV 1851
Query: 6016 PDLAPYQDEEKSTDALPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSET 6195
Q E T L +++PILR LQLLCENHN LQNFLR Q+++TN+NLV ET
Sbjct: 1852 ------QSNEMGTSVL-----IMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCET 1900
Query: 6196 LSFLDTVCGSTKGSLGVFG-EIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQE-NGL 6369
L FLD +CGST G LG+ G I E N L+ QTL TLTE+CQGPCHENQ + E NG+
Sbjct: 1901 LQFLDIMCGSTTGGLGLLGLYINEDNVGLVIQTLETLTEYCQGPCHENQTCIVTHESNGI 1960
Query: 6370 NIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGP 6549
+II +L+LN+I PL M+L L++K ASKLLLA+MESRHD ENA R+L +S P
Sbjct: 1961 DIITALILNDISPLCKYRMDLVLQLKDNASKLLLALMESRHDSENAERIL-----ISLRP 2015
Query: 6550 KQLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASG 6729
++LV IK+AY R+ D ++ G I + + L N
Sbjct: 2016 QELVDVIKKAYLQEEE-------------RENSDVSPREVGHNIYILALQLSRHNKQLQ- 2061
Query: 6730 IVSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKK 6909
H K + +++ ++ L++++ +L L S +
Sbjct: 2062 ----HLLKPVKRIQEEEAEG-----------------ISSMLSLNNKQLTQMLKSSAPVQ 2100
Query: 6910 DDLTREALNYYKERTAQIEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGS 7089
+ + L YY+ T+QIEIVR+DR++E++VFP+ IC +LT++TK ++ TE+D QGS
Sbjct: 2101 EQ-EEDPLAYYENHTSQIEIVRQDRSMEQIVFPVPGICQFLTEETKHRLFTTTEQDEQGS 2159
Query: 7090 KVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLP 7269
KV++ FD+ +++EM WQRKL+ + W + R+ LW +SF+ A +N ++A +YP
Sbjct: 2160 KVSDLFDQPSFLHNEMEWQRKLRSMPLIYWFSRRMTLWGSISFNLAVFINIIIAFFYPYV 2219
Query: 7270 EHSNSSI---SLGNLYSWFAVFSSFLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVT 7440
E +++ + L +L W + S R+ + +G+
Sbjct: 2220 EGASTGVLGSPLISLLFWILICFSIAALFTKRY-------SVRPLIVALILRSIYYLGIG 2272
Query: 7441 LTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPM 7620
TL I G L L NKIV VV+FV N+G R ++ Y + Y+ +LGL H +
Sbjct: 2273 PTLNILGALNLTNKIVFVVSFVGNRGTFIRGYKAMVMDMEFLYHVGYILTSVLGLFAHEL 2332
Query: 7621 IYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEV 7800
Y ILLFD+I+ EETL NVI SVTRN +SI+ T LLALIL+Y FSI+GFL+ + DF LEV
Sbjct: 2333 FYSILLFDLIYREETLFNVIKSVTRNGRSILLTALLALILVYLFSIVGFLFLKDDFILEV 2392
Query: 7801 DPVENDSSATISSGIPS------ETCPSEGCP-----GLQPSXXXXXXXXXXXXSCETLW 7947
D + + S G+P TC + + +C+TL
Sbjct: 2393 DRLPGNHSRANPLGMPHGAATFVNTCSGDNVDCVSGVSVPEVLAEDEEPDSTERACDTLL 2452
Query: 7948 MCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTXXXXXXXXXXXXXXXXXXDT 8127
MCI+ GLRNGGG+GD+LR P+ E +F RV YD+ DT
Sbjct: 2453 MCIVTVMNHGLRNGGGVGDILRKPSKDESLFPARVVYDLLFFFIVIIIVLNLIFGVIIDT 2512
Query: 8128 FGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLYYIVMLQIKD 8307
F DLR+EK +KE+ILK CFICGL+R +FDN++V+FE H + EHN+W+YLY+IV++++K+
Sbjct: 2513 FADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKFEHNMWNYLYFIVLVRVKN 2572
Query: 8308 ETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLLQMMTLMREI 8487
+T++TGPESYVAQ +K++NLDWFPRM+A+SL SE + +Q+E++ ++D+L M L+ +
Sbjct: 2573 KTDYTGPESYVAQMIKNKNLDWFPRMRAMSLVSSEGEGEQNEIRILQDKLSATMKLVSHL 2632
Query: 8488 ISQNEESRAFMEQFQPR 8538
+Q E + M + + R
Sbjct: 2633 TAQLSELKEQMTEQRKR 2649
>gi|31217824|ref|XP_316515.1| ENSANGP00000004303 [Anopheles gambiae]
gi|30176080|gb|EAA11872.2| ENSANGP00000004303 [Anopheles gambiae str.
PEST]
Length = 2636
Score = 1544 bits (3997), Expect = 0.0
Identities = 1030/2821 (36%), Positives = 1496/2821 (52%), Gaps = 117/2821 (4%)
Frame = +1
Query: 385 AADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRA 564
AA+ E+++NESE +K LG V+QYGS+VQLLH+KSNKY+TV PA E+NAM+VYLD
Sbjct: 3 AAEIEKKQNESENKKLLGTVVQYGSVVQLLHLKSNKYVTVNIRLPALLEKNAMRVYLDAN 62
Query: 565 GNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLS-SFNLLDHQS 741
GNEGSWF I P YK + GDNV +K+ L P + + + LH++ ++ L D+
Sbjct: 63 GNEGSWFYIMPFYKLRSAGDNVVVSDKVILKPVNAN-------RQNLHVAVTYELPDNPG 115
Query: 742 AAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDV 921
+ EVN LN T W++ +F+ ENQ++ +K GDVVRLFHA+Q+ FLT+D KQ
Sbjct: 116 SKEVNVLNSSTSWKITLFMEQRENQEDVLKGGDVVRLFHAEQEKFLTMDEYKKQQH---- 171
Query: 922 VFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQV 1101
VFLR T R SA ATSS+ALWEV+VVQ ++ RGG WN +RFKHLAT YL+AE
Sbjct: 172 VFLRTTGRSSATAATSSKALWEVEVVQHDSCRGGAGHWNSLFRFKHLATGYYLAAE---- 227
Query: 1102 QVKPAMNGRRASLIYSKTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPEE 1281
D T +S+ ++ + L P
Sbjct: 228 -------------------------IDEDISRTEKSSSSSHPQGGDSFRLVPVPHS---S 259
Query: 1282 DANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWVK 1461
D +F+LD +T + VP+ SYVRL H S WVHAT+ + ++ K
Sbjct: 260 DIASVFELDSTTITRPEGLVPQSSYVRLRHLCSSTWVHATSVPIDID-----DDKPVMSK 314
Query: 1462 VICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQL 1641
V C + DKE F L+PV+P EVRDLDFANDACK L ++ G + S E S L
Sbjct: 315 VGCSAIKEDKEAFQLIPVSPVEVRDLDFANDACKLLLAMSTKLENGTISSNER-RSLIAL 373
Query: 1642 LIDCILFVTNSSD--HLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTT 1815
L D + F+ + + +D L ++ +P+RDRQKLLREQ +L Q+F +L+ PF Q T
Sbjct: 374 LQDIVFFIAGQENDQNKSDALDLTINNPNRDRQKLLREQYILKQLFKILQGPF---QETK 430
Query: 1816 XXXXXXXXXXXXXDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDL 1995
D +N FK +F+LCY +LK SQ YRKNQE++A+ FG +Q+QIG+D+
Sbjct: 431 NNDGPFLKIDELGDPKNAPFKNIFRLCYRILKLSQQDYRKNQEYIAKHFGLMQKQIGYDI 490
Query: 1996 MAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNR---QGKFLDYLADLCVCRGEANK 2166
+AEDT+TA+LHNN KLLEK++ +E FV LVR N Q +FLDYL+DLCV +A
Sbjct: 491 LAEDTITALLHNNRKLLEKHITAAEIETFVGLVRKNMQSWQSRFLDYLSDLCVSNKKAIA 550
Query: 2167 KIQELICTSVLSSKHRDIFMDTKIID---------GEIEVG------------WA--PNF 2277
QELIC SVLSSK+ DI ++T + + E+E G W
Sbjct: 551 VTQELICKSVLSSKNADILIETFLREVDDDPLGYLSELERGNHEKKRYEVVLMWTNRTQS 610
Query: 2278 RKLVDIAEGAK-SNSDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPA 2454
+ + +A+G K + D LDYYRHQL+L S MC +QYLA++ N+S L
Sbjct: 611 KSMSRLAQGLKIGRAVDTAILDYYRHQLNLFSNMCLNRQYLALN--------NLSPHLDI 662
Query: 2455 ELVLQCMSDNRLPYDLRGSFTRLMLHLHVVRG--SPMSAIRHARLWWSIPENVNVSTYES 2628
+L+L+CMSD +PYDLR SF RLMLHLHV R P++ +++ARLW IP ++++ Y+
Sbjct: 663 DLILRCMSDKTVPYDLRASFCRLMLHLHVDRDPQEPVTPVKYARLWSEIPTVMSINDYD- 721
Query: 2629 VSVEAYSDGSRMRIGEGIAHKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKAL 2808
+E D ++ + +K +A VE YL M + +KLT+E+V LA+ L
Sbjct: 722 --IEKQLDSNKEAV-RARFNKTIAFVEDYLCNHVVSKMWFADQ-DQNKLTFEVVKLARDL 777
Query: 2809 AQFNFYSFNDLLQLTQNLLAII-----NEGPATEQVPSH--RAMVNAIRNMSKSMMRGGN 2967
F FYSF+DLL+LT+ LL I+ +E T H ++ I +M M
Sbjct: 778 IYFGFYSFSDLLRLTKTLLNILDCVSSSEADGTGLPTGHIDCGVLRRIGDMGAVMTSLTL 837
Query: 2968 KENSKDLAKTPSVTAEEAGRTKEGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKN 3147
S + + + + L + TKL + EILQF++DVR DYRI+ LS FK
Sbjct: 838 GPISTAIVSPTIQHRKSVSQLMKEYPLVMDTKLKIIEILQFILDVRLDYRISCLLSIFKR 897
Query: 3148 VFPCDE-------DGSLMHSA-SINERMAS-ELYDAIYRSSG---------HELHLDGRD 3273
F +E D SL +A +IN R + +L Y++ G + L LDG+
Sbjct: 898 EFDENEQTASTATDTSLPPTAENINLRQKNIDLESIGYQAEGIFGCTEDTYNPLDLDGQG 957
Query: 3274 GQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQID 3453
G+ L +LL + M +YP L S AL + FRHF+Q E+L +QVQLLVS++DVE+Y+QI
Sbjct: 958 GRTFLRVLLHLIMHEYPALVSGALHLLFRHFSQRHEVLHAFRQVQLLVSDSDVESYKQIK 1017
Query: 3454 RDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEA 3633
DL +L+ EKSELWV+ +K+ D DL + + G+ +
Sbjct: 1018 SDLDVLRQSVEKSELWVY-------KSKQTD-------------DLLAGGGGEGGEGGDG 1057
Query: 3634 LMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTG 3813
E P + E Q Y I+Q+L+R+
Sbjct: 1058 SGGKGGEQGPELNPEQSQ----------------------------EYKKIQQILIRMNK 1089
Query: 3814 MCYRKGDP----KPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRS 3981
+C P KP Q+LL+N+ V+ VVL+ + +P+D+K D+ M +L+ L+HEFL++
Sbjct: 1090 LCITATGPDGFVKPRKHEQRLLRNVGVHTVVLDLLQIPYDEKDDYRMNELMRLAHEFLQN 1149
Query: 3982 FCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHI 4161
FC N++NQ L+K + G+L ET+ AIF++N L + V ++++ H
Sbjct: 1150 FCLGNQQNQILLHK--QLDLFLNPGILEAETV------CAIFKDNLNLCNEVSDKVVQHF 1201
Query: 4162 VGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELE 4341
V IE + R+ +L+ LQ ++ ++ I Q+ V E+ A +EV Y D SF
Sbjct: 1202 VHCIEIHGRHVEYLKFLQTIIKAENQFIRKCQDMVMQELVNAGEEVLVFYNDKGSFNYFV 1261
Query: 4342 AMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTA 4521
+M+ S G +D L YHIELV+LLA CT GKN TE+KC S + +D IV +++
Sbjct: 1262 ELMR--SYSAGTLADP-SPLMYHIELVKLLACCTMGKNVYTEIKCNSLLALDDIVAMISH 1318
Query: 4522 KQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHIL-NNLLEDIRSLRVEKLTGAET 4698
C+ EVK Y+ L HCYIDT+ E+K+ Y + ++ + + L DI + V K
Sbjct: 1319 PDCIPEVKVAYVDFLCHCYIDTEVEVKEIYSSNHMWCLFEKSFLIDINN--VVKGGSFTN 1376
Query: 4699 ATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGKLRGSKS 4878
LE+Y+C+ V +L FF + +S A + + F ++L L + K G
Sbjct: 1377 KQLENYVCNEVMNILTTFFNSQFSDQSTA---LQKRQLIFVKILQNSFKLTQCK--GLTP 1431
Query: 4879 SRNWYRVAECIKRLTKWAEEHNITLPATLAGP--QMSGQTSVRQKWQQAASSAKWIGIGK 5052
S+ + V CI+ L++ A+ I +P L +M +T++ + ++KW+ + K
Sbjct: 1432 SQR-FNVENCIRTLSEKAKPRGIAIPIDLENQVVKMFNKTAMLSR-----QTSKWLLVTK 1485
Query: 5053 RLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLH 5232
+ + S S +++ ++ + L PL AE S+LV++L+
Sbjct: 1486 QTKMER-----------SQSQIMRMDRSIIEGLQDIVSLLEDKLKPLVEAEQSLLVDILY 1534
Query: 5233 TPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKM--CDCTKXX 5406
ELLFP + R +C G + LI+H + L++ K++ LC ++L+TL +M DC
Sbjct: 1535 RSELLFPLNTESRKKCETGDFIRHLIKHTEKLLEEKEEKLCVKILKTLKEMMTIDC---D 1591
Query: 5407 XXXXXXXXXXXXXXRYFGHHNNHHPPLDRQQSXXXXXXXXXXXXXXXTWS---------- 5556
RYFG+ P+ S
Sbjct: 1592 YGDKGDHLRTILLKRYFGNDFTLQAPVAALPGAVGPAVLQPANVSTAVGSPMASVSHGPG 1651
Query: 5557 ------QERDLYAIQCKLNDAGASDLVTDIIIME-PSREIFLKAIHLARALLHEGNDKVQ 5715
R L+ +Q L+ GASDLV +++I S IF++AI L ALL GN +Q
Sbjct: 1652 AKYLIRAGRTLHEVQNHLDKEGASDLVIELVIKSINSPSIFVEAIELGIALLEGGNPIIQ 1711
Query: 5716 HSFYMRMKQKDIHEPFFKAILTRIQTAQNRLKSDM-MSCSDSKPKVSLSATVSRRSSTVL 5892
Y + D+ + FFK +++ AQ +KS + ++ SD + A S + +
Sbjct: 1712 KGMYNKFLSNDLSQSFFKVFFDKMKDAQQEIKSTVTVNTSDGEQGKRKQAAASDGTGS-- 1769
Query: 5893 TPLIDAGDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPE 6072
D G +L + ++E L ++D++++ + L +
Sbjct: 1770 -------DNGDENSLMSIGSSALEDILAE-------------KLEKHKDKDEN-NKLSNK 1808
Query: 6073 VALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFG 6252
V +++PILR LQLLCENHN LQN LR Q+++TN+NLVSETL FLD +CGST G LG+ G
Sbjct: 1809 VLVMQPILRFLQLLCENHNPELQNLLRNQNNKTNYNLVSETLMFLDCICGSTTGGLGLLG 1868
Query: 6253 -EIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQE-NGLNIIISLVLNEIKPLADDHM 6426
I E+N SLI QTL TLTE+CQGPCH+NQN +A E NGL+II +L+LN+I PL + M
Sbjct: 1869 LYINENNVSLINQTLETLTEYCQGPCHDNQNCIATHESNGLDIITALILNDINPLGKNRM 1928
Query: 6427 ELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHH 6606
+L LE+K+ ASKLLLAIMESR D ENA R+L NM PKQLV +A + +
Sbjct: 1929 DLVLELKNNASKLLLAIMESRGDSENAERILANM-----NPKQLVEVACRAGGGGVDDGY 1983
Query: 6607 MLKSISRDLFRQAEDD-----LKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSL 6771
+ DL DD K+ G I + L + N + +G++ I T ++
Sbjct: 1984 --GGLRHDLGDDGHDDDDVGVSPKEVGHNIYILCHQLAQHNKELAGLLKIDTYNGSGTAG 2041
Query: 6772 DDKFN-DDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKE 6948
+ P +P +G A + + K + T +AL YY+
Sbjct: 2042 SNAAPIVPTFPGANPSSLGGGPPSSAS------------ANSAASKANSKTNQALLYYQT 2089
Query: 6949 RTAQIEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMY 7128
TAQIEIVR DRTLE++VFPI +IC YLTKDTK V N ERD+QGSKV +FFD E M+
Sbjct: 2090 HTAQIEIVRHDRTLEQIVFPIPEICEYLTKDTKVRVLNTAERDDQGSKVADFFDRHEAMF 2149
Query: 7129 HEMIWQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYP----LPEHSNSSISL 7296
+EM WQ+KL+ + L W + + LW+ + F+ A ++N +VA +YP LPE S SL
Sbjct: 2150 NEMKWQKKLRGQPALFWVSSYMSLWSNILFNLAVLINLIVAFFYPFENALPELSFHLSSL 2209
Query: 7297 GNLYSWFAVFSSFLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGILQLV 7476
W + S + L G TL++ G + ++
Sbjct: 2210 ----IWIVMLVSLAIVITLPR-----QSGIRTFVVALILRLIFSCGPEPTLWLLGCITVI 2260
Query: 7477 NKIVHVVAFVSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFT 7656
K VH+++ + N G ++ I+ L Y YL C+ G+L+HP + ILLFD+++
Sbjct: 2261 MKGVHIISLMGNYGTLEKHFVSIITDAELLYHFFYLLFCVFGVLLHPFFFSILLFDVVYR 2320
Query: 7657 EETLQNVIASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVD--------PVE 7812
EETL NVI SVTRN +SI+ T +LALIL+Y FSI+G+++FR DF + VD P
Sbjct: 2321 EETLLNVIRSVTRNGRSIILTAVLALILVYMFSIIGYMFFRDDFLVPVDEEYTPPAIPTA 2380
Query: 7813 NDS-----SATISSGIPSE--------TCPSEGCPGLQPSXXXXXXXXXXXXSCETLWMC 7953
D+ SAT+S +P + TC PG + C+++ MC
Sbjct: 2381 GDAGCTGDSATVSHMVPPDVVDQVVQATCSKP--PGTASTELADDGGEMKERGCDSMIMC 2438
Query: 7954 ILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTXXXXXXXXXXXXXXXXXXDTFG 8133
I+ T QGLRNGGGIGD+LR P+ E +F+ RV YD+ DTF
Sbjct: 2439 IITTLNQGLRNGGGIGDILRAPSRKETLFVPRVVYDLLFFFIVIIIVLNLIFGVIIDTFA 2498
Query: 8134 DLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLYYIVMLQIKDET 8313
DLR+EK +KE ILKN CFICGL+RS FDN++V+FE H + EHN+WHYLY+IV++++KD T
Sbjct: 2499 DLRSEKQQKELILKNTCFICGLNRSAFDNKTVSFEEHIKNEHNMWHYLYFIVLVKVKDPT 2558
Query: 8314 EFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLLQMMTLMREIIS 8493
EFTGPESYV VK DWFPR++A+SL + D +Q E++ +K+ L +RE+++
Sbjct: 2559 EFTGPESYVHAMVKANIQDWFPRLRAMSLAAVDGDGEQIELRSLKNLLETNHIAVRELMT 2618
Query: 8494 Q 8496
Q
Sbjct: 2619 Q 2619
>gi|50760465|ref|XP_418035.1| PREDICTED: similar to Inositol
1,4,5-trisphosphate receptor type 3 (Type 3 inositol
1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor)
(IP3 receptor isoform 3) (InsP3R3) [Gallus gallus]
Length = 3027
Score = 1266 bits (3275), Expect = 0.0
Identities = 864/2568 (33%), Positives = 1329/2568 (51%), Gaps = 149/2568 (5%)
Frame = +1
Query: 1282 DANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWVK 1461
D LF+LDP+T K++ VPR SYVRL H ++ W+ +TN + + +
Sbjct: 656 DIASLFELDPTTLQKTDSFVPRNSYVRLRHLCTNTWIQSTNVP----IDIDEERPIRLML 711
Query: 1462 VICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQL 1641
C + DKE FA++ V E+RDLDFANDA L N ++ + G +S+ QL
Sbjct: 712 GTCP-TKEDKEAFAIVSVPVSEIRDLDFANDASSMLANVVEKMNEG-FLSQNDRRFVIQL 769
Query: 1642 LIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXX 1821
L D + FV++ ++ + L I P+R+RQKL+REQ +L Q+F +LKAPF + G
Sbjct: 770 LEDLVFFVSDVPNNGQNVLDIVVTKPNRERQKLMREQNILKQIFGILKAPFKDKGGE--- 826
Query: 1822 XXXXXXXXXXXDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMA 2001
D +N ++ MF+LCY +L++SQ YRKNQE +A++FG +Q QIG+D++A
Sbjct: 827 -GPLVRLEELSDQKNAPYQYMFRLCYRVLRHSQEDYRKNQEHIAKQFGMMQSQIGYDILA 885
Query: 2002 EDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEANKKIQEL 2181
EDT+TA+LHNN KLLEK++ VE FV LVR NR+ +FLDYL+DLCV A QEL
Sbjct: 886 EDTITALLHNNRKLLEKHITKTEVETFVSLVRKNREPRFLDYLSDLCVSNHIAIPVTQEL 945
Query: 2182 ICTSVLSSKHRDIFMDTKI-----------------IDGEIEVGWAP-----NFRKLVDI 2295
IC VL K+ DI + T++ + E+ + W + + + +
Sbjct: 946 ICKCVLDPKNSDILIKTELRPVKEMSQTHEYLSIEYSEEEVWLTWTDKNNDHHEKSIRQL 1005
Query: 2296 AEGAKS-NSDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQC 2472
A+ A++ N+ D L YYR+QL L ++MC ++QYLAI ISQQL +L+ C
Sbjct: 1006 AQEARAGNAHDENVLSYYRYQLKLFARMCLDRQYLAI--------KEISQQLGVDLIFLC 1057
Query: 2473 MSDNRLPYDLRGSFTRLMLHLHVVRGSP--MSAIRHARLWWSIPENVNVSTYESVSVEAY 2646
M+D LP+DLR SF LMLH+HV R + ++ ARLW IP + + Y+S ++ A
Sbjct: 1058 MADEMLPFDLRASFCHLMLHVHVDRDPQELVMPVKFARLWTEIPTAITIKDYDS-NLNAS 1116
Query: 2647 SDGSRMRIGEGIAHKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFY 2826
D + + + VE YL + ++++ +KLT+E+V+LA L F FY
Sbjct: 1117 RDDKKNKFA-----STMEFVEDYLNNVVSEAVPFANE-EKNKLTFEVVSLAHNLIYFGFY 1170
Query: 2827 SFNDLLQLTQNLLAIINEGPATEQVPSHRAMVNAI-------RNMSKSMMRGGNKENSKD 2985
SF++LL+LT+ LL II + V + + M+ A+ +N+ +S+ G ++
Sbjct: 1171 SFSELLRLTRTLLGII------DCVQNPQLMMQAVYSDEVTGKNVRRSIQGVGQMMSTMV 1224
Query: 2986 LAK------TPSVTAEEA------GRTKEGRALNV-KTKLIVAEILQFVMDVRRDYRITM 3126
L++ PS++A A GR+ E + V +TKL + EILQF+++VR DYRI+
Sbjct: 1225 LSRKQSIFSPPSLSAGSAPEPVDRGRSVENENIVVMETKLKILEILQFILNVRLDYRISY 1284
Query: 3127 ALSWFK----NVFPCDE---DGSL----MHSASINERMASELYDAIY--RSSGHELHLDG 3267
LS FK V+P + DG+ +A++N E +A++ + L +D
Sbjct: 1285 LLSVFKKEFVEVYPMQDSAADGTAPAFDSTTAAMNLDRIGEHAEAMFGVGKTSSMLEVDD 1344
Query: 3268 RDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLK---------------- 3399
G++ L +L+ +TM DYPPL S +L++ F+HF+Q QE+L K
Sbjct: 1345 EGGRMFLRVLIHLTMHDYPPLISGSLQLLFKHFSQRQEVLHTFKQVTLERLHLMASLLWE 1404
Query: 3400 -------------------------QVQLLVSNNDVENYRQIDRDLFILKNLTEKSELW- 3501
QVQLL+S DVENY+ I +L L+ + EKSELW
Sbjct: 1405 EIQARRGVGFMPQTSCTGKSLGMSLQVQLLISAQDVENYKVIKSELDKLRTMVEKSELWV 1464
Query: 3502 -----VHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPS 3666
V GD ++D + ++KE T + +++ KS +E+Y
Sbjct: 1465 DKKGSVKGD--SNVDGNKKEKKEHTADEEVIAPGEKS-----------------SENYQI 1505
Query: 3667 IRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDPKPD 3846
++ +L RL MC +
Sbjct: 1506 VKG---------------------------------------ILERLNKMC--GVGEQVR 1524
Query: 3847 TMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKF 4026
Q+LLKNM ++V+L+ + +P++ K D MM+++ +H+FL+ FC N+ENQ+ L+K
Sbjct: 1525 KKQQRLLKNMDAHKVMLDLLQIPYE-KGDAKMMEILKFTHQFLQKFCAGNQENQALLHKH 1583
Query: 4027 ISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLE 4206
++ G+L ET++ IF NN +L S + E + H + + + R+ +L+
Sbjct: 1584 LNL--FLTPGLLEAETMQH------IFLNNYQLCSEINETVPQHFIHCVATHGRHVQYLD 1635
Query: 4207 LLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSD 4386
L ++ K ++ Q+ + E+ A D+V Y D AS L MM ++ +S
Sbjct: 1636 FLHTIIKAEGKYVKKCQDMIMTELTNAGDDVVVFYNDKASLATLLEMMTAARDGVEENS- 1694
Query: 4387 SRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLL 4566
L YHI LV LLA C GKN TE+KC S +P++ +VRVVT + C+ EVK Y+ +
Sbjct: 1695 ---PLMYHISLVDLLAACAEGKNVYTEIKCTSLLPLEDVVRVVTHEDCITEVKMAYVNFV 1751
Query: 4567 LHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEKLTGAETATLEHYICHTVTEVLI 4746
HCY+DT+ EMK+ Y + ++ + N D+ + ++ TLE Y+ V + +
Sbjct: 1752 NHCYVDTEVEMKEIYTSNHIWTLFENFTLDMAQMCKKREKRLPDPTLEKYVLTVVLDTIN 1811
Query: 4747 KFFEAPYSALQQAKVDVHHHKKTFSEV------LLELTYLEKGKLRGSKSSRNWYRVAEC 4908
FF +P+S + + H+ ++ LLE ++L+ + KSS V C
Sbjct: 1812 AFFSSPFS---ENSTSLQTHQTIVVQLLQSTMRLLECSWLQ----QQHKSS-----VEAC 1859
Query: 4909 IKRLTKWAEE---HNITLPA--------TLAGPQMSGQTSVRQKWQQAASSAKWIGIGKR 5055
I+ L +E + LPA + P + S+ A + +
Sbjct: 1860 IRTLAMVGKELCRRDALLPACQRDAAALAASAPAAAKSRSIALPMDLDAHVSSLLNSSST 1919
Query: 5056 LNRQNTLNPGHRLYGT----SNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVE 5223
Q + T S + + N++ +I + L PL AE SVLV+
Sbjct: 1920 STVQRNTSSYKTATRTFPRVSTTPNQWDYKNIIEKLQDIINALEDRLKPLVEAELSVLVD 1979
Query: 5224 VLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKX 5403
VLH PELLF EG+ +C GG ++KL+QH K LM+ ++ LC +VL+TL +M
Sbjct: 1980 VLHRPELLFMEGTEAYQRCESGGFLSKLVQHTKDLMET-EEKLCIKVLRTLQQM------ 2032
Query: 5404 XXXXXXXXXXXXXXXRYFGHHNN-------HHPPLDRQQSXXXXXXXXXXXXXXXTWSQE 5562
+G N ++ +++ S WS
Sbjct: 2033 -----------LVKRNKYGERGNLLRKMLLNNYLQNKKSSSKGEIVDAAGGGQDQDWSA- 2080
Query: 5563 RDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQ 5742
+ A+QC+L+ GA+ LV D+I+ + +IF ++I LA LL GN ++Q SFY M
Sbjct: 2081 --IAAVQCRLDREGATKLVADLIMNTKNEKIFQESILLAIRLLDGGNTEIQKSFYNLMTS 2138
Query: 5743 KDIHEPFFKAILTRIQTAQNRLKSDM---MSCSDSKPKVSLSATVSRRSSTVLTPLIDAG 5913
E FFK + R++ AQ KS + MS +KP+ D G
Sbjct: 2139 DKKSEKFFKVLHDRMKKAQQETKSTVSVNMSDIGNKPREDKDEP-------------DPG 2185
Query: 5914 DTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPEVALVEPI 6093
G G F +P ++ + +D E+ + + V ++EPI
Sbjct: 2186 TKG-RGETFMMPGTPSRYPLALGFRKGHD-----------TGEQGQNNEMGVTVLIMEPI 2233
Query: 6094 LRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFG-EIGEHN 6270
LR LQLLCENHN LQNFLR Q+++TN+NLV ETL FLD +CGST G LG+ G I E+N
Sbjct: 2234 LRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDIMCGSTTGGLGLLGLYINEYN 2293
Query: 6271 FSLITQTLATLTEFCQGPCHENQNTMAMQE-NGLNIIISLVLNEIKPLADDHMELALEIK 6447
+LITQTL TLTE+CQGPCHENQ+ + E NG++II +L+LN+I PL M+L L++K
Sbjct: 2294 VALITQTLETLTEYCQGPCHENQSCIVTHESNGIDIITALILNDISPLCKYRMDLVLQLK 2353
Query: 6448 SQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISR 6627
ASKLLLA+MESRHD ENA R+L +S P++LV IK+AY +
Sbjct: 2354 DNASKLLLALMESRHDSENAERIL-----ISLRPQELVDVIKKAY------------LQE 2396
Query: 6628 DLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSV 6807
+ AE ++ G I + + L N + + K I ++
Sbjct: 2397 EECENAEVS-PREVGHNIYILALQLSRHNKSLQQL--LKPVKRIQEEEEEG--------- 2444
Query: 6808 DPREVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRT 6987
++ L++++ +L L + +++ + L YY++ T+QIEIVR DR+
Sbjct: 2445 -----------ISSMLSLNNKQLTQMLKSTAPVQEE-EEDPLAYYEKHTSQIEIVRLDRS 2492
Query: 6988 LERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRK 7167
+E+++FP+ IC +LTK+TK ++ TE+D QGSKV++FFD+ +++EM WQ+KL+
Sbjct: 2493 MEQIIFPVPGICEFLTKETKYRLFTTTEQDEQGSKVSDFFDQSSFLHNEMEWQKKLRSMP 2552
Query: 7168 WLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSI---SLGNLYSWFAVFSSFL 7338
+ W + R+ LW +SF+ A +N ++A +YP E ++ + L +L W + S +
Sbjct: 2553 LMYWFSRRMTLWGSISFNLAVFINIIIAFFYPYVEATSMGVLDSPLISLLFWILICFSIM 2612
Query: 7339 LAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVAFVSNKG 7518
R+ L +G+ LTL I G L L NKIV VV+FV N+G
Sbjct: 2613 ALFTKRYGVRPL-------LVALILRSIYYLGIGLTLNILGALNLTNKIVFVVSFVGNRG 2665
Query: 7519 LEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRN 7698
R ++ Y + Y+ +LGL VH + Y ILLFD+I+ EETL NVI SVTRN
Sbjct: 2666 TFIRGYKAMIMDVEFLYHVGYILTSVLGLFVHELFYSILLFDLIYREETLFNVIKSVTRN 2725
Query: 7699 YQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIP------SETC 7860
+SI+ T LLALIL+Y FSI+GFL+ + DF LEVD + + + G+ E+C
Sbjct: 2726 GRSILLTALLALILVYLFSIVGFLFLKDDFILEVDRLPDSKAQDDPLGMQRNMETFMESC 2785
Query: 7861 PSE--GCPGLQPSXXXXXXXXXXXXSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWED 8034
+ C + P+ +C+TL MCI+ GLRNGGG+GD+LR P+ E
Sbjct: 2786 SGDKISCSAV-PTALQEADTDQWERACDTLLMCIVTVLNHGLRNGGGVGDILRKPSKDES 2844
Query: 8035 MFIWRVAYDMTXXXXXXXXXXXXXXXXXXDTFGDLRAEKNEKEQILKNNCFICGLDRSRF 8214
+F RV YD+ DTF DLR+EK +KE+ILK CFICGL+R +F
Sbjct: 2845 LFPARVVYDLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKF 2904
Query: 8215 DNRSVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQAL 8394
DN++V+FE H + EHN+W+YLY+IV++++K++T++TGPESYVAQ +K++NLDWFPRM+A+
Sbjct: 2905 DNKTVSFEEHIKYEHNMWNYLYFIVLVRVKNKTDYTGPESYVAQMIKNKNLDWFPRMRAM 2964
Query: 8395 SLQDSELDTDQSEVKQMKDQLLQMMTLMREIISQNEESRAFMEQFQPR 8538
SL +E + +Q+E++ ++D+L M L+ + SQ E + M + + R
Sbjct: 2965 SLVSNEGEGEQNEIRNLQDKLNSTMKLVSHLTSQLNELKEQMTEQRKR 3012
Score = 211 bits (536), Expect = 3e-52
Identities = 115/269 (42%), Positives = 159/269 (58%), Gaps = 36/269 (13%)
Frame = +1
Query: 190 LVDDRCIVELKDGRPESPPKKFR------------------------------------D 261
LVDDRC+VE G ++PPKKFR D
Sbjct: 331 LVDDRCVVEPAAGDLDNPPKKFRALPQPYILAHQEEANGMPQFCAQQDLSPPPILKKIPD 390
Query: 262 CLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGN 441
CLFKVCP+NRY+AQK W ++ Q + + D L+ KL+ AA E+++NE+E +K G+
Sbjct: 391 CLFKVCPMNRYSAQKQYWKAKQTKQDKEKIADVVLLQKLQHAAQMEQKQNETENKKVHGD 450
Query: 442 VIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIG 621
V++YGS++QLLH+KSNKY+TV K PA E+NAM+V LD GNEGSW I+P +K + G
Sbjct: 451 VVKYGSVIQLLHMKSNKYLTVNKRLPALLEKNAMRVTLDATGNEGSWLFIQPFWKLRSNG 510
Query: 622 DNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLL 801
DNV G+K+ L P AG LH S++ L D+ EVN +N T W++ +F+
Sbjct: 511 DNVVVGDKVILNP-----VNAG---QPLHASNYELADNAGCKEVNSVNCNTSWKINLFMQ 562
Query: 802 FDENQQNSVKSGDVVRLFHADQQTFLTLD 888
F ++ + +K GDVVRLFHA+Q+ FLT D
Sbjct: 563 FRDHMEEVLKGGDVVRLFHAEQEKFLTCD 591
>gi|476810|pir||A40743 IP3 receptor, XIP3R - African clawed frog
gi|464220|dbj|BAA03304.1| inositol 1,4,5-triphosphate receptor
[Xenopus laevis]
Length = 2693
Score = 1235 bits (3195), Expect = 0.0
Identities = 828/2246 (36%), Positives = 1202/2246 (52%), Gaps = 88/2246 (3%)
Frame = +1
Query: 109 LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
LH+GDI+SLY E S N GF++TLGLVDDR +V+ G +PPKKFRDCLF++CP+N
Sbjct: 9 LHVGDIVSLYAEGSVN----GFINTLGLVDDRSVVQPDAGDLNNPPKKFRDCLFRLCPMN 64
Query: 289 RYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQ 468
RY+AQK W K S D L+NKL AAD E+++NE+E +K LG VIQYG+++Q
Sbjct: 65 RYSAQKQFWKAAK--PGASSTTDTVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQ 122
Query: 469 LLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKI 648
LLH+KSNKY+TV K PA E+NAM+V LD AGNEGSWF I+P YK +IGD+V G+K+
Sbjct: 123 LLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGDKV 182
Query: 649 SLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSV 828
L P AG LH SS L D+ EVN +N T W++ +F+ + +N+ + +
Sbjct: 183 VLNP-----VNAG---QPLHASSQQLSDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDIL 234
Query: 829 KSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTN 1008
K GDVVRLFHA+Q+ FLT D K+ VFLR T R SA ATSS+ALWEV+VVQ +
Sbjct: 235 KGGDVVRLFHAEQEKFLTCDEHRKKQH----VFLRTTGRQSATSATSSKALWEVEVVQHD 290
Query: 1009 AYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRRASLIYSKTNNPMAMYSDGP 1188
RGG WN +RFKHLAT YL+AE + +P R ++ K + +G
Sbjct: 291 PCRGGAGYWNSLFRFKHLATGHYLAAE---IDAEPDAGNARMQVVPEKMMCTLISVPEG- 346
Query: 1189 NGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLL 1368
D + +F+LDP+T + VPR SYVRL
Sbjct: 347 ------------------------------NDISSIFELDPTTLRGGDSLVPRNSYVRLR 376
Query: 1369 HQSSDKWVHATNATEKQNLHYSSKNEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFA 1548
H ++ WVH+TN+ ++ + + +++ + DKE FA++PV+P EVRDLDFA
Sbjct: 377 HLCTNTWVHSTNSPIDKD-----EEKPVMLRIGTSPVKEDKEAFAIVPVSPAEVRDLDFA 431
Query: 1549 NDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRD 1728
NDA K L + ++ G + E + T+LL + + FVT + D L++ P+R+
Sbjct: 432 NDASKVLSSIAGKLEKGTITQNER-RAVTKLLEELVYFVTGLVNSGHDILEVLVNKPNRE 490
Query: 1729 RQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIFKTMFQLCYCLL 1908
RQKL+REQ +L Q+F LL+APF T D R+ F+ + +LCY +L
Sbjct: 491 RQKLMREQNILKQIFKLLQAPF-----TDSGDGPMLRLEELGDQRHAPFRHICRLCYRVL 545
Query: 1909 KYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVE 2088
++SQ YRKNQE++A++FG +Q+QIG+D++AEDT+TA+LHNN KLLEK++ ++ FV
Sbjct: 546 RHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKHITAAEIDTFVS 605
Query: 2089 LVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKII--------- 2241
LVR NR+ +FLDYL+DLCV ++ QELIC +VL+ + DI ++TK++
Sbjct: 606 LVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPANADILIETKLVLSRFEFEGV 665
Query: 2242 ---DGEIEVG---------WAPN-----FRKLVDIAEGAK-SNSDDAEHLDYYRHQLDLL 2367
+ +E G W + R + ++A+ AK +D + L+YYR+QL+L
Sbjct: 666 ASGESSLEAGEDEEEVWLFWKASNKEIRSRSVRELAQDAKEGQKEDQDVLNYYRYQLNLF 725
Query: 2368 SQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLHLHVVR 2547
++MC ++QYLAI+ IS QL +L+L+CMSD LP+DLR SF RLMLH+HV R
Sbjct: 726 ARMCLDRQYLAIN--------EISGQLDVDLILRCMSDENLPFDLRASFCRLMLHMHVDR 777
Query: 2548 G--SPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATVETYLM 2721
++ +++ARLW IP + + Y+S S SR I E A + + VE YL
Sbjct: 778 DPQEQVTPVKYARLWSEIPSEIAIDDYDS------SGTSRDDIKERFA-QTMEFVEEYLR 830
Query: 2722 GLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINEGPATEQV 2901
+ Q +KLT+E+VNLA+ L F FY+F+DLL+LT+ LLAI++
Sbjct: 831 DVVGQRFPFADK-EKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAIVDCVHLIANF 889
Query: 2902 PS--------HRAMVNAIRN-------MSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKE 3036
PS + N +R+ M++ ++RGG +A P T + ++
Sbjct: 890 PSGKLGKGEESKGGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMA-APEGTIKAQREPEK 948
Query: 3037 GRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHS--------AS 3192
L + TKL + EILQF+++VR DYRI+ L FK+ F S+ S +
Sbjct: 949 EDILVMDTKLKIIEILQFILNVRLDYRISCLLCIFKSEFDESNAQSVEGSTEAITVVPGT 1008
Query: 3193 INERMASELYDAIYRSSGHE--LHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHF 3366
++ E + I+ S L LD G+ L +LL +TM DYPPL S AL + FRHF
Sbjct: 1009 LDFEHIEEQAEGIFGGSEENTPLDLDDDGGRTFLRVLLHLTMHDYPPLVSGALHLLFRHF 1068
Query: 3367 TQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVH-GDRHHSIDTKEV 3543
+Q QE+L+ KQVQLLV++ DV+NY+QI +DL L+++ EKSELWV+ G + +
Sbjct: 1069 SQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGSGPEEVTAAQA 1128
Query: 3544 DEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRN 3723
++ ++P +S + +Y ++ E L L++L ++++
Sbjct: 1129 GGADKG----------ETPGKAKKSESTSSY------NYRVVK-EILLRLSKLCVQENTT 1171
Query: 3724 DAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEF 3903
Q+ + A+ ++ ++L + Y K + DT Q+++K
Sbjct: 1172 GRRNRKQQQRLLRNMGAHSVVLELL----QIPYEKTE---DTRMQEIMK----------- 1213
Query: 3904 ISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEE 4083
++HEFL++FC N++NQ+ L+K I+ + I E
Sbjct: 1214 ------------------IAHEFLQNFCAGNQQNQALLHKHIN--------LFLTPGILE 1247
Query: 4084 VGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEK 4263
T+ IF NN +L S + E ++ H IE + RN +++ LQ +V + I+ Q+
Sbjct: 1248 AVTMQHIFMNNFQLCSEINERVVQHFAHCIETHGRNVQYIKFLQTIVKAEGRYIKKCQDI 1307
Query: 4264 VANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCT 4443
V E+ + ++V Y D ASF+ L MM+ E+E D L YHI LV LLA+CT
Sbjct: 1308 VMAELVNSGEDVLVFYNDRASFQTLVQMMRSERE----RMDENSPLMYHIHLVELLAVCT 1363
Query: 4444 RGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEY 4623
GKN TE+KC S +P+D IVRVVT + C+ EVK Y+ L HCY+DT+ EMK+ Y + +
Sbjct: 1364 EGKNVYTEIKCNSLLPLDDIVRVVTHEDCVPEVKIAYINFLNHCYVDTEVEMKEIYTSNH 1423
Query: 4624 VDHILNNLLEDIRSLRVEKLTGAE---TATLEHYICHTVTEVLIKFFEAPYS----ALQQ 4782
+ + N L DI RV T LE Y+ V ++ FF +P+S LQ
Sbjct: 1424 MWKLFENFLVDI--CRVCNSTSDRKHADIVLERYVTEIVMSIVNTFFSSPFSDQSTTLQA 1481
Query: 4783 AKVDVHHHKK--TFSEVLLEL--TYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNIT 4950
+K+ V H + F ++L + Y L K+S V CI+ L+ A+ I
Sbjct: 1482 SKLAVVHQTRQPVFVQLLQAIFRVYHCNWLLPSQKAS-----VESCIRVLSDVAKSRTIA 1536
Query: 4951 LPATLAGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHTS 5130
+P L + Q+ A S W + R++++ R Y
Sbjct: 1537 IPVDLDSQVNNLFLKSHNIVQKTAMS--WRMSVRNAARRDSVLTASRDY----------- 1583
Query: 5131 ANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLI 5310
N++ ++ + L PL AE SVLV+VLH PELLFPE + R +C G + KLI
Sbjct: 1584 RNIIERLQDIVSSLEDRLRPLVQAELSVLVDVLHRPELLFPENTDARKKCESGQFICKLI 1643
Query: 5311 QHCKTLMQNKQDNLCARVLQTLCKMCDCTKXXXXXXXXXXXXXXXXRYFGHHNNHHPPLD 5490
+H K L++ ++ LC +VLQTL +M RY+G+ P
Sbjct: 1644 RHTKLLLEENEEKLCIKVLQTLREMM-AKDRGFGDKGEALRVILVNRYYGNIR----PAG 1698
Query: 5491 RQQS-----------XXXXXXXXXXXXXXXTWSQERDLYAIQCKLNDAGASDLVTDIIIM 5637
R++S E L +QC L+ GASDLV D+I+
Sbjct: 1699 RRESLTSFGNGPLSGGSSGKSGGGSIGSGSLSRSEMSLSDVQCHLDKQGASDLVIDLIMN 1758
Query: 5638 EPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRLKSD 5817
S +F ++I LA ALL GN +QHSF+ R+ + E FFK R++ AQ +K+
Sbjct: 1759 ATSDRVFHESILLAIALLEGGNTTIQHSFFCRLTEDKKSEKFFKVFFDRMKVAQQEIKAT 1818
Query: 5818 M-MSCSDSKPKVSLSATVSRRSSTVLTPLIDAGDTGFNGALFEVPQQVRHPSISEMSQLS 5994
+ ++ SD K S TP E +Q+ S++
Sbjct: 1819 VTVNTSDLGSKKR-----DEEQSERETPHHQRVREPSGQITEEAKEQLIEASVATKKAYY 1873
Query: 5995 NDLTHSIPDLAPYQDE------EKSTDALPPE--VALVEPILRVLQLLCENHNSLLQNFL 6150
+ + PD E EK D L + +++PILR LQLLCENHN LQNFL
Sbjct: 1874 SFRREADPDDHFSLGEGVMAVAEKGRDELEMSAVITIMQPILRFLQLLCENHNRDLQNFL 1933
Query: 6151 RKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFG-EIGEHNFSLITQTLATLTEFCQGPC 6327
R Q++++N+NLV ETL FLD +CGST G LG+ G I E N +LI QTL +LTE+CQGPC
Sbjct: 1934 RCQNNKSNYNLVCETLQFLDCICGSTTGGLGLLGLYINEKNVALINQTLESLTEYCQGPC 1993
Query: 6328 HENQNTMAMQE-NGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIMESRHDGEN 6504
HENQN +A E NG++II +L+LN+I PL M+L LE+K+ ASKLLLAIMESRHD EN
Sbjct: 1994 HENQNCIATHESNGIDIITALILNDINPLGRKRMDLVLELKNNASKLLLAIMESRHDSEN 2053
Query: 6505 ANRVLRNMANMSGGPKQLVHAIKQAY 6582
A R+L NM PK+LV IK+AY
Sbjct: 2054 AERILYNMR-----PKELVEVIKKAY 2074
Score = 458 bits (1179), Expect = e-127
Identities = 245/588 (41%), Positives = 355/588 (59%), Gaps = 13/588 (2%)
Frame = +1
Query: 6802 SVDPREVGHNIYILAHQLAIHDGELEIWLD-GSDEKKDDLTREALNYYKERTAQIEIVRR 6978
+ PR VGHNIYILAHQLA H+ EL+ L G + D EAL +Y + TAQIEIVR
Sbjct: 2091 AASPRNVGHNIYILAHQLARHNKELQHMLKPGVQTGEGD---EALEFYAKHTAQIEIVRL 2147
Query: 6979 DRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQ 7158
DRT+E++VFP+ IC +LTK++K +Y TERD QGSK+ +FF E +++EM WQ+KL+
Sbjct: 2148 DRTMEQIVFPVPSICEFLTKESKLRIYYTTERDEQGSKIHDFFQRSEDLFNEMNWQKKLR 2207
Query: 7159 DRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPE-HSNSSISLGNLYSWFAVFSSF 7335
++ L WC+ + W+ +SF+ A ++N LVA +YP H + S + W A+ S
Sbjct: 2208 AQQVLYWCSRNMTFWSSISFNLAVLMNLLVAFFYPFVNVHGGTLDSRLSGLLWTAMLVSL 2267
Query: 7336 LLAHYLRHDKIYLHKTXXXXXXXXXXXXXX--XIGVTLTLYIFGILQLVNKIVHVVAFVS 7509
+ I L K IG+ TL++ G + NKI+ + +FV
Sbjct: 2268 AIV-------IVLPKPHGIRALIASTILRLIFSIGLQPTLFLLGAFNVCNKIIFLTSFVG 2320
Query: 7510 NKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASV 7689
N+G R ++ Y L+YL IC +G+ VH Y +LLFD+++ EETL NVI SV
Sbjct: 2321 NRGTFTRGYGAMVLDVEFLYHLLYLLICAMGVFVHEFFYSLLLFDLVYREETLLNVIKSV 2380
Query: 7690 TRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPS------ 7851
TRN +SI+ T +LALIL+Y FSI+G+L+F+ DF LEVD ++N++ + G +
Sbjct: 2381 TRNGRSIILTAVLALILVYLFSIVGYLFFKDDFILEVDRLQNETIFPENGGTMTSELLYP 2440
Query: 7852 ETC---PSEGCPGLQPSXXXXXXXXXXXXSCETLWMCILQTGYQGLRNGGGIGDVLRNPA 8022
E C C + + +CETL MCI+ GLR+GGG+GDVLR P+
Sbjct: 2441 EVCRVGSDTNCTHEELAQVTEEEEEEKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPS 2500
Query: 8023 PWEDMFIWRVAYDMTXXXXXXXXXXXXXXXXXXDTFGDLRAEKNEKEQILKNNCFICGLD 8202
E +F RV YD+ DTF DLR+EK +KE++LK CFICGL+
Sbjct: 2501 KEEPLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEVLKTTCFICGLE 2560
Query: 8203 RSRFDNRSVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPR 8382
R +FDN++ TFE H + EHN+WHYL++IV++++KD TE+TGPESYVA+ +KDRNLDWFPR
Sbjct: 2561 RDKFDNKTATFEEHFKEEHNMWHYLFFIVLVKVKDSTEYTGPESYVAEMIKDRNLDWFPR 2620
Query: 8383 MQALSLQDSELDTDQSEVKQMKDQLLQMMTLMREIISQNEESRAFMEQ 8526
M+A+SL S+ + +Q+E++ ++++L M L+ + Q E + M +
Sbjct: 2621 MRAMSLVSSDSEGEQNELRNLQEKLESTMRLVTNLSGQLSELKDQMTE 2668
>gi|44888998|sp|P29993|IP3R_DROME Inositol 1,4,5-trisphosphate
receptor (InsP3 receptor) (InsP3R)
Length = 2838
Score = 1122 bits (2903), Expect = 0.0
Identities = 756/2225 (33%), Positives = 1135/2225 (50%), Gaps = 132/2225 (5%)
Frame = +1
Query: 2248 EIEVGWA--PNFRKLVDIAEGAKSNSDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPER 2421
EI + W P R + D+A +A L+YYRHQL+L S MC +QYLA++
Sbjct: 763 EIHLKWTGQPTSRSMADLAS-CDGGELEAAILNYYRHQLNLFSNMCLNRQYLALN----- 816
Query: 2422 RLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLHLHVVRG--SPMSAIRHARLWWSI 2595
+S +L +L+L+CMSD +PY+LR SF RLMLHLHV R P++ +++ARLW I
Sbjct: 817 ---ELSPRLDIDLILKCMSDETMPYELRASFCRLMLHLHVDRDPQEPVTPVKYARLWSEI 873
Query: 2596 PENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATVETYLMGLRNQSMEERQSVNSSKL 2775
P +++ Y+ + + + R + +A VE YL + + +KL
Sbjct: 874 PSKMSIQDYDGKNQQPDQNKQACRAK---FNTTIAFVENYLCNVATKVWLFTDQ-EQNKL 929
Query: 2776 TYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINEGPATEQVPSHRAMVNAIRNMSKSMM 2955
T+E+V LA+ L F FYSF+DLL+LT+ LL+I++ T ++++ + +
Sbjct: 930 TFEVVKLARDLIYFGFYSFSDLLRLTKTLLSILDCVSDTSSGEFASTDIDSVEEETNAEA 989
Query: 2956 RGGNKENSKDL---------------AKTPSVTAEE---AGRTKEGRALNVKTKLIVAEI 3081
GG + D+ P+++ ++ + + L + TKL + EI
Sbjct: 990 EGGVLRSIGDINTVMTSLALGSVGQAIAAPTISLQQRKSVSQLMKEYPLVMDTKLKIIEI 1049
Query: 3082 LQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASE--------------- 3216
LQF++DVR DYRI+ LS FK F E + S +++ + +
Sbjct: 1050 LQFILDVRLDYRISCLLSIFKREFDESEVAASAASNEASQQQSQQQEPQTPGSSNETDPL 1109
Query: 3217 ----------------------------------LYDAIYRSSGHELHLDGRDGQLLLAI 3294
++D RS L LDG+ G+ L +
Sbjct: 1110 DSAESVAAGAAAAAATTARQKNIDLESIGVQAEGIFDC-ERSDAANLDLDGQGGRTFLRV 1168
Query: 3295 LLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILK 3474
LL + M DY PL S AL + FRHF+Q QE+L+ +QVQLLVS++DVE+Y+QI DL IL+
Sbjct: 1169 LLHLIMHDYAPLVSGALHLLFRHFSQRQEVLQAFRQVQLLVSDSDVESYKQIKSDLDILR 1228
Query: 3475 NLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNE 3654
EKSELWV+ K DE T D+G +L
Sbjct: 1229 QSVEKSELWVY-------KAKATDELGAT----------------DAGGDAVSLE----- 1260
Query: 3655 HYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGD 3834
N L ++ RN+ Y ++++L+R+ C
Sbjct: 1261 ------------YNAALSQEQRNE----------------YRKVKEILIRMNKFCVTASG 1292
Query: 3835 P----KPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKE 4002
P KP Q+LL+N+ V+ VVL+ + P+D+K D M +L+ L+HEFL++FC N++
Sbjct: 1293 PGSVVKPRKHEQRLLRNVGVHTVVLDLLQNPYDEKDDELMKELMCLAHEFLQNFCLGNQQ 1352
Query: 4003 NQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHN 4182
NQ L+ + + I E T+ AIF++N L + V ++++ H V IE +
Sbjct: 1353 NQVLLHNHLD--------LFLNPGILEAKTVCAIFKDNLALCNEVTDKVVQHFVHCIEIH 1404
Query: 4183 SRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEK 4362
R+ +L+ LQ +V ++ I Q+ V E+ + ++V Y D SF MM+ +
Sbjct: 1405 GRHVAYLQFLQTVVAAENQFIRRCQDMVMQELINSGEDVLVFYNDKGSFNHFVQMMQQQM 1464
Query: 4363 ESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEV 4542
+ SD LKYH+ELV+LLA CT GKN TE+KC + + +D IV ++ C+ EV
Sbjct: 1465 LGMEKLSDDS-PLKYHVELVKLLACCTMGKNVYTEIKCNNLLSLDDIVTIICHPLCMPEV 1523
Query: 4543 KTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILN-NLLEDIRSLRVEKLTGAETATLEHYI 4719
K Y+ L HCYIDT+ EMK+ Y + ++ + + L DI L + A TL+ Y+
Sbjct: 1524 KEAYVDFLNHCYIDTEVEMKEIYASGHMWSLFEKSFLVDINQL-ITNPAAASNKTLQAYV 1582
Query: 4720 CHTVTEVLIKFFEAPYS---ALQQAKVDVHHHKKTFSEVLLELTYLEKGKLRGSKSSRNW 4890
+ VT +L FF +P+S A+ Q++ + + + + +L G +
Sbjct: 1583 LNGVTNLLGSFFASPFSDQSAIVQSRQLIFVQLLQAAHRITQCRWLSLG---------DR 1633
Query: 4891 YRVAECIKRLTKWAEEHNITLPATLAGP--QMSGQTSVRQKWQQAASSAKWIGIGKRLNR 5064
+ V CI+ LT+ A+ +I LP L MS +T++ + + KW+ K+
Sbjct: 1634 FNVENCIRTLTESAKMRSIALPPELEQQVATMSSKTAMLTR-----QTTKWLLASKQ--- 1685
Query: 5065 QNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPEL 5244
P + ++ M S ++ ++ + L P+ AE S+LV++L+ EL
Sbjct: 1686 -----PKYEAQQAASLMRWDRS--IIEGLQDIVSLLEDQLKPVVEAELSLLVDILYRSEL 1738
Query: 5245 LFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKXXXXXXXX 5424
LFP G+ R +C GG + KLI+H + L++ K++ +C +VL+TL +M
Sbjct: 1739 LFPAGTEARKRCESGGFIRKLIKHTEKLLEEKEERMCVKVLRTLREMM-AIDVNYGEKGD 1797
Query: 5425 XXXXXXXXRYFGHHNNHHPPLDRQQSXXXXXXXXXXXXXXXTWSQE--------RDLYAI 5580
RYF + P D T + L+ +
Sbjct: 1798 ALRQTLLLRYFQTKSTPRLPEDEVPLLAAPLMDPAKQNHLVTHGPGAKYLQRAGKTLHEM 1857
Query: 5581 QCKLNDAGASDLVTDIIIMEP-SREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHE 5757
Q L+ GASDLV +++I S IF++A+ L ALL GN +Q + + D+++
Sbjct: 1858 QNHLDREGASDLVVELVIKSVHSPNIFVEAVELGIALLEGGNPIIQKGMFQKFLSDDLNQ 1917
Query: 5758 PFFKAILTRIQTAQNRLKSDMM--------SCSDSKPKVSLSATVSRR------SSTVLT 5895
FFK +++ AQ +KS + + K +L R + V+T
Sbjct: 1918 AFFKVFFEKMKDAQQEIKSTVTVNTTDIAAKAHEHKQDTNLELDKIARKHGLKSNGVVIT 1977
Query: 5896 P-----LIDAG--DTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKST 6054
L +AG G + +IS S L + L L ++D
Sbjct: 1978 EELKRELHNAGLATARAYGNARNIHSGEESSAISVNSPLEDILAEK---LEKHKDSRDQR 2034
Query: 6055 DALPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKG 6234
+ L +V +++PILR LQLLCENHN +QN LR Q+++TN+NLVSETL FLD +CGST G
Sbjct: 2035 NQLSNKVLVMQPILRFLQLLCENHNPDMQNLLRNQNNKTNNNLVSETLMFLDCICGSTTG 2094
Query: 6235 SLGVFG-EIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQE-NGLNIIISLVLNEIKP 6408
LG+ G I EHN +LI QTL LTE+CQGPCHENQN +A E NGL+II +L+LN I P
Sbjct: 2095 GLGLLGLYINEHNLALINQTLEALTEYCQGPCHENQNCIATHESNGLDIITALILNNINP 2154
Query: 6409 LADDHMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEM 6588
L ++ M+L LE+K+ ASKLLLAIMESR D ENA R+L NM PKQLV +AY
Sbjct: 2155 LGENRMDLVLELKNNASKLLLAIMESRGDSENAERILYNM-----NPKQLVEVACKAYHQ 2209
Query: 6589 TNSNHHMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSS 6768
+L + +D + +G
Sbjct: 2210 ------------EELIDEQDDGDEPDAG-------------------------------- 2225
Query: 6769 LDDKFNDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKK----DDLTREALN 6936
+DDD +V PREVGHNIYIL HQLA H+ EL L S++ + D T +AL
Sbjct: 2226 -----SDDDDATVSPREVGHNIYILCHQLAQHNKELAGLLKASEDPQSASFDAKTSQALM 2280
Query: 6937 YYKERTAQIEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEW 7116
YY TAQIEIVR DRTLE++VFPI +IC YLT DTK + N ERD+QGSK+ +FFD+
Sbjct: 2281 YYATHTAQIEIVRNDRTLEQIVFPIPEICEYLTTDTKIKILNTAERDDQGSKLADFFDKA 2340
Query: 7117 ETMYHEMIWQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYP----LPEHSNS 7284
E M++EM WQ+KL+ + L W + + LW+ + F+ ++N +VA +YP +PE S S
Sbjct: 2341 EEMFNEMKWQKKLRSQPLLFWISSYMSLWSNILFNCVVVINMIVAFFYPFDNTVPELS-S 2399
Query: 7285 SISLGNLYSWFAVFSSFLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGI 7464
ISL L+ +FS ++ R I +G TL + G+
Sbjct: 2400 HISL--LFWIITIFSLVIVLALPRESGI------RTFIGSVILRFIFLLGPESTLCLLGV 2451
Query: 7465 LQLVNKIVHVVAFVSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFD 7644
+ + K VH+V+ + NKG ++ + +I+ L Y +Y+ C GL+ HP Y +LLFD
Sbjct: 2452 VTVTLKSVHIVSIMGNKGTLEKQLIKIITDFQLLYHCIYIAFCFCGLIFHPFFYSLLLFD 2511
Query: 7645 IIFTEETLQNVIASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSS 7824
+++ EETL NVI SVTRN +SIV T +LALIL+Y FSI+G+++F+ DF + VD E D++
Sbjct: 2512 VVYREETLVNVIRSVTRNGRSIVLTAVLALILVYLFSIIGYMFFKDDFLVSVDFEEQDNA 2571
Query: 7825 A------TISSGIPSETCPSEGCPG-----LQPSXXXXXXXXXXXXSCETLWMCILQTGY 7971
T+S + ++C + G + + SC++L MCI+ T
Sbjct: 2572 PPPSVPLTLSVPVSGDSCSAPDDLGNCQAAKEVAPPSAGGGEVKERSCDSLVMCIVTTLN 2631
Query: 7972 QGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTXXXXXXXXXXXXXXXXXXDTFGDLRAEK 8151
QGLRNGGGIGD+LR P+ E +F+ RV YD+ DTF DLR+EK
Sbjct: 2632 QGLRNGGGIGDILRAPSSKEGLFVARVIYDLLFFFIVIIIVLNLIFGVIIDTFADLRSEK 2691
Query: 8152 NEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPE 8331
+KE ILK CFIC L+RS FDN++V+FE H ++EHN+WHYLY+IV++++KD TEFTGPE
Sbjct: 2692 QQKEAILKTTCFICSLNRSAFDNKTVSFEEHIKSEHNMWHYLYFIVLVKVKDPTEFTGPE 2751
Query: 8332 SYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLLQMMTLMREIISQNEESR 8511
SYV VK L+WFPR++A+SL + D +Q E++ M+ QLL L++ + +Q E +
Sbjct: 2752 SYVYAMVKAGILEWFPRLRAMSLAAVDADGEQIELRSMQAQLLDTQLLIKNLSTQLHELK 2811
Query: 8512 AFMEQ 8526
M +
Sbjct: 2812 DHMTE 2816
Score = 543 bits (1398), Expect = e-152
Identities = 321/727 (44%), Positives = 439/727 (60%), Gaps = 12/727 (1%)
Frame = +1
Query: 94 GNNGNLHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFK 273
G+ LH+GDI+SLY E S GFLSTLGLVDDR +V + G PPKKFRDCL K
Sbjct: 7 GSASFLHLGDIVSLYAEGSVC----GFLSTLGLVDDRTVVCPEAGDLSCPPKKFRDCLIK 62
Query: 274 VCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQY 453
+CP+NRY+AQK W K Q+ S D +L+ +L AA+ E+++NE+E +K LG IQY
Sbjct: 63 ICPMNRYSAQKQFWKAAK--QSASSNTDPNLLKRLHHAAEIEKKQNETENKKLLGTSIQY 120
Query: 454 G-SMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNV 630
G ++VQLLH+KSNKY+TV K P+ E+NAM+VYLD GNEGSWF I+P YK +IGD V
Sbjct: 121 GRAVVQLLHLKSNKYLTVNKRLPSLLEKNAMRVYLDANGNEGSWFYIKPFYKLRSIGDYV 180
Query: 631 SA-GNKISLIPNSVSTTQAGHVKSQLHLSS-FNLLDHQSAAEVNCLNEPTEWQVFMFLLF 804
G+K+ L P + + LH+++ + L D+ EVN LN T W++ +F+
Sbjct: 181 VVVGDKVILSPVNAD-------QQNLHVAANYELPDNPGCKEVNVLNSSTSWKISLFMEH 233
Query: 805 DENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALW 984
ENQ++ +K GDVVRLFHA+Q+ FLT+D KQ VFLR T R SA ATSS+ALW
Sbjct: 234 KENQEHILKGGDVVRLFHAEQEKFLTMDEYKKQYH----VFLRTTGRTSATAATSSKALW 289
Query: 985 EVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRRAS---LIYSKT 1155
E++VVQ ++ RGG WN YRFKHLAT YL+AE AM+ AS L
Sbjct: 290 EIEVVQHDSCRGGAGDWNSLYRFKHLATGHYLAAEAEIDVSAGAMSATSASGHDLHLGDC 349
Query: 1156 NNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNK 1335
+ + N N+ Q + SV P ++ +F LD +T + +
Sbjct: 350 SKDSGLSCSTMNSTINDKPKGKQYRLVSV----PYSADIAS-----VFVLDATTMARPDS 400
Query: 1336 EVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWVKVIC-EKNRVDKETFALLP 1512
VP+ SYVRL H S+ WVHAT+ + + ++K + ++C + DKE FAL+P
Sbjct: 401 LVPQSSYVRLQHICSNTWVHATS------IPIDADDDKPVMSMVCCSPIKEDKEAFALIP 454
Query: 1513 VNPDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTN--SSDHL 1686
V+P EVRDLDFANDACK L + G + E + LL D + F+ + +
Sbjct: 455 VSPVEVRDLDFANDACKVLATVTSKLDNGSISINER-RALISLLQDIVYFIAGMENEQNK 513
Query: 1687 ADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRN 1866
L+ + +P RDRQKLLREQ +L Q+F +L+ PF Q T D +N
Sbjct: 514 TKALEFTIKNPIRDRQKLLREQYILKQLFKILQGPF---QEHTAGDGPFLRLDELSDPKN 570
Query: 1867 EIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLL 2046
+K +F+LCY +L+ SQ YRKNQE++A+ FG +Q+QIG+D++AEDT+TA+LHNN KLL
Sbjct: 571 SPYKNIFRLCYRILRLSQQDYRKNQEYIAKHFGLMQKQIGYDILAEDTITALLHNNRKLL 630
Query: 2047 EKYVKTPHVERFVELVRNNR---QGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRD 2217
EK++ +E FV LVR N +FLDYL+DLCV +A QELIC SVLS K++D
Sbjct: 631 EKHITAAEIETFVGLVRKNMHNWDSRFLDYLSDLCVSNRKAIAVTQELICKSVLSDKNKD 690
Query: 2218 IFMDTKI 2238
I ++T++
Sbjct: 691 ILIETQV 697
>gi|24644261|ref|NP_730942.1| CG1063-PA [Drosophila melanogaster]
gi|23170366|gb|AAF52015.2| CG1063-PA [Drosophila melanogaster]
Length = 2828
Score = 1122 bits (2902), Expect = 0.0
Identities = 759/2217 (34%), Positives = 1139/2217 (51%), Gaps = 124/2217 (5%)
Frame = +1
Query: 2248 EIEVGWA--PNFRKLVDIAEGAKSNSDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPER 2421
EI + W P R + D+A +A L+YYRHQL+L S MC +QYLA++
Sbjct: 762 EIHLKWTGQPTSRSMADLAS-CDGGELEAAILNYYRHQLNLFSNMCLNRQYLALN----- 815
Query: 2422 RLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLHLHVVRG--SPMSAIRHARLWWSI 2595
+S +L +L+L+CMSD +PY+LR SF RLMLHLHV R P++ +++ARLW I
Sbjct: 816 ---ELSPRLDIDLILKCMSDETMPYELRASFCRLMLHLHVDRDPQEPVTPVKYARLWSEI 872
Query: 2596 PENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATVETYLMGLRNQSMEERQSVNSSKL 2775
P +++ Y+ + + + R + +A VE YL + + +KL
Sbjct: 873 PSKMSIQDYDGKNQQPDQNKQACRAK---FNTTIAFVENYLCNVATKVWLFTDQ-EQNKL 928
Query: 2776 TYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIIN------EGP-ATEQVPSHRAMVNAIR 2934
T+E+V LA+ L F FYSF+DLL+LT+ LL+I++ G A+ + S ++ +I
Sbjct: 929 TFEVVKLARDLIYFGFYSFSDLLRLTKTLLSILDCVSDTSSGEFASTDIDSEGGVLRSIG 988
Query: 2935 NMSKSMMRGGNKENSKDLAKTPSVTAEE---AGRTKEGRALNVKTKLIVAEILQFVMDVR 3105
+++ M + +A P+++ ++ + + L + TKL + EILQF++DVR
Sbjct: 989 DINTVMTSLALGSVGQAIA-APTISLQQRKSVSQLMKEYPLVMDTKLKIIEILQFILDVR 1047
Query: 3106 RDYRITMALSWFKNVFPCDEDGSLMHSASINERMASE----------------------- 3216
DYRI+ LS FK F E + S +++ + +
Sbjct: 1048 LDYRISCLLSIFKREFDESEVAASAASNEASQQQSQQQEPQTPGSSNETDPLDSAESVAA 1107
Query: 3217 --------------------------LYDAIYRSSGHELHLDGRDGQLLLAILLQMTMSD 3318
++D RS L LDG+ G+ L +LL + M D
Sbjct: 1108 GAAAAAATTARQKNIDLESIGVQAEGIFDC-ERSDAANLDLDGQGGRTFLRVLLHLIMHD 1166
Query: 3319 YPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSEL 3498
Y PL S AL + FRHF+Q QE+L+ +QVQLLVS++DVE+Y+QI DL IL+ EKSEL
Sbjct: 1167 YAPLVSGALHLLFRHFSQRQEVLQAFRQVQLLVSDSDVESYKQIKSDLDILRQSVEKSEL 1226
Query: 3499 WVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNE 3678
WV+ K DE T D+G +L
Sbjct: 1227 WVY-------KAKATDELGAT----------------DAGGDAVSLE------------- 1250
Query: 3679 CLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDP----KPD 3846
N L ++ RN+ Y ++++L+R+ C P KP
Sbjct: 1251 ----YNAALSQEQRNE----------------YRKVKEILIRMNKFCVTASGPGSVVKPR 1290
Query: 3847 TMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKF 4026
Q+LL+N+ V+ VVL+ + P+D+K D M +L+ L+HEFL++FC N++NQ L+
Sbjct: 1291 KHEQRLLRNVGVHTVVLDLLQNPYDEKDDELMKELMCLAHEFLQNFCLGNQQNQVLLHNH 1350
Query: 4027 ISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLE 4206
+ + I E T+ AIF++N L + V ++++ H V IE + R+ +L+
Sbjct: 1351 LD--------LFLNPGILEAKTVCAIFKDNLALCNEVTDKVVQHFVHCIEIHGRHVAYLQ 1402
Query: 4207 LLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSD 4386
LQ +V ++ I Q+ V E+ + ++V Y D SF MM+ + + SD
Sbjct: 1403 FLQTVVRAENQFIRRCQDMVMQELINSGEDVLVFYNDKGSFNHFVQMMQQQMLRMEKLSD 1462
Query: 4387 SRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLL 4566
LKYH+ELV+LLA CT GKN TE+KC + + +D IV ++ C+ EVK Y+ L
Sbjct: 1463 DS-PLKYHVELVKLLACCTMGKNVYTEIKCNNLLSLDDIVTIICHPLCMPEVKEAYVDFL 1521
Query: 4567 LHCYIDTDAEMKDAYKTEYVDHILN-NLLEDIRSLRVEKLTGAETATLEHYICHTVTEVL 4743
HCYIDT+ EMK+ Y + ++ + + L DI L + A TL+ Y+ + VT +L
Sbjct: 1522 NHCYIDTEVEMKEIYASGHMWSLFEKSFLVDINQL-ITNPAAASNKTLQAYVLNGVTNLL 1580
Query: 4744 IKFFEAPYS---ALQQAKVDVHHHKKTFSEVLLELTYLEKGKLRGSKSSRNWYRVAECIK 4914
FF +P+S A+ Q++ + + + + +L G + + V CI+
Sbjct: 1581 GSFFASPFSDQSAIVQSRQLIFVQLLQAAHRITQCRWLSLG---------DRFNVENCIR 1631
Query: 4915 RLTKWAEEHNITLPATLAGP--QMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGH 5088
LT+ A+ +I LP L MS +T++ + + KW+ K+ P +
Sbjct: 1632 TLTESAKMRSIALPPELEQQVATMSSKTAMLTR-----QTTKWLLASKQ--------PKY 1678
Query: 5089 RLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSAL 5268
++ M S ++ ++ + L P+ AE S+LV++L+ ELLFP G+
Sbjct: 1679 EAQQAASLMRWDRS--IIEGLQDIVSLLEDQLKPVVEAELSLLVDILYRSELLFPAGTEA 1736
Query: 5269 RDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKXXXXXXXXXXXXXXXX 5448
R +C GG + KLI+H + L++ K++ +C +VL+TL +M
Sbjct: 1737 RKRCESGGFIRKLIKHTEKLLEEKEERMCVKVLRTLREMM-AIDVNYGEKGDALRQTLLL 1795
Query: 5449 RYFGHHNNHHPPLDRQQSXXXXXXXXXXXXXXXTWSQE--------RDLYAIQCKLNDAG 5604
RYF + P D T + L+ +Q L+ G
Sbjct: 1796 RYFQTKSTPRLPEDEVPLLAAPLMDPAKQNHLVTHGPGAKYLQRAGKTLHEMQNHLDREG 1855
Query: 5605 ASDLVTDIIIMEP-SREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEPFFKAILT 5781
ASDLV +++I S IF++A+ L ALL GN +Q + + D+++ FFK
Sbjct: 1856 ASDLVVELVIKSVHSPNIFVEAVELGIALLEGGNPIIQKGMFQKFLSDDLNQAFFKVFFE 1915
Query: 5782 RIQTAQNRLKSDMM--------SCSDSKPKVSLSATVSRR------SSTVLTP-----LI 5904
+++ AQ +KS + + K +L R + V+T L
Sbjct: 1916 KMKDAQQEIKSTVTVNTTDIAAKAHEHKQDTNLELDKIARKHGLKSNGVVITEELKRELH 1975
Query: 5905 DAG--DTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPEVA 6078
+AG G + +IS S L + L L ++D + L +V
Sbjct: 1976 NAGLATARAYGNARNIHSGEESSAISVNSPLEDILAEK---LEKHKDSRDQRNQLSNKVL 2032
Query: 6079 LVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFG-E 6255
+++PILR LQLLCENHN +QN LR Q+++TN+NLVSETL FLD +CGST G LG+ G
Sbjct: 2033 VMQPILRFLQLLCENHNPDMQNLLRNQNNKTNNNLVSETLMFLDCICGSTTGGLGLLGLY 2092
Query: 6256 IGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQE-NGLNIIISLVLNEIKPLADDHMEL 6432
I EHN +LI QTL LTE+CQGPCHENQN +A E NGL+II +L+LN I PL ++ M+L
Sbjct: 2093 INEHNVALINQTLEALTEYCQGPCHENQNCIATHESNGLDIITALILNNINPLGENRMDL 2152
Query: 6433 ALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHML 6612
LE+K+ ASKLLLAIMESR D ENA R+L NM PKQLV +AY
Sbjct: 2153 VLELKNNASKLLLAIMESRGDSENAERILYNM-----NPKQLVEVACKAYHQ-------- 2199
Query: 6613 KSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDD 6792
+L + +D + +G +DD
Sbjct: 2200 ----EELIDEQDDGDEPDAG-------------------------------------SDD 2218
Query: 6793 DIPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKK----DDLTREALNYYKERTAQ 6960
D +V PREVGHNIYIL HQLA H+ EL L S++ + D T +AL YY TAQ
Sbjct: 2219 DDATVSPREVGHNIYILCHQLAQHNKELAGLLKASEDPQSASFDAKTSQALMYYATHTAQ 2278
Query: 6961 IEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMI 7140
IEIVR DRTLE++VFPI +IC YLT DTK + N ERD+QGSKV +FFD+ E M++EM
Sbjct: 2279 IEIVRNDRTLEQIVFPIPEICEYLTTDTKIKILNTAERDDQGSKVADFFDKAEEMFNEMK 2338
Query: 7141 WQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYP----LPEHSNSSISLGNLY 7308
WQ+KL+ + L W + + LW+ + F+ ++N +VA +YP +PE S S ISL L+
Sbjct: 2339 WQKKLRSQPLLFWISSYMSLWSNILFNCVVVINMIVAFFYPFDNTVPELS-SHISL--LF 2395
Query: 7309 SWFAVFSSFLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIV 7488
+FS ++ R I +G TL + G++ + K V
Sbjct: 2396 WIITIFSLVIVLALPRESGI------RTFIGSVILRFIFLLGPESTLCLLGVVTVTLKSV 2449
Query: 7489 HVVAFVSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETL 7668
H+V+ + NKG ++ + +I+ L Y +Y+ C GL+ HP Y +LLFD+++ EETL
Sbjct: 2450 HIVSIMGNKGTLEKQLIKIITDFQLLYHCIYIAFCFCGLIFHPFFYSLLLFDVVYREETL 2509
Query: 7669 QNVIASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSA------T 7830
NVI SVTRN +SIV T +LALIL+Y FSI+G+++F+ DF + VD E D++ T
Sbjct: 2510 VNVIRSVTRNGRSIVLTAVLALILVYLFSIIGYMFFKDDFLVSVDFEEQDNAPPPSVPLT 2569
Query: 7831 ISSGIPSETCPSEGCPG-----LQPSXXXXXXXXXXXXSCETLWMCILQTGYQGLRNGGG 7995
+S + ++C + G + + SC++L MCI+ T QGLRNGGG
Sbjct: 2570 LSVPVSGDSCSAPDDLGNCQAAKEVAPPSAGGGEVKERSCDSLVMCIVTTLNQGLRNGGG 2629
Query: 7996 IGDVLRNPAPWEDMFIWRVAYDMTXXXXXXXXXXXXXXXXXXDTFGDLRAEKNEKEQILK 8175
IGD+LR P+ E +F+ RV YD+ DTF DLR+EK +KE ILK
Sbjct: 2630 IGDILRAPSSKEGLFVARVIYDLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQQKEAILK 2689
Query: 8176 NNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVK 8355
CFIC L+RS FDN++V+FE H ++EHN+WHYLY+IV++++KD TEFTGPESYV VK
Sbjct: 2690 TTCFICSLNRSAFDNKTVSFEEHIKSEHNMWHYLYFIVLVKVKDPTEFTGPESYVYAMVK 2749
Query: 8356 DRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLLQMMTLMREIISQNEESRAFMEQ 8526
L+WFPR++A+SL + D +Q E++ M+ QLL L++ + +Q E + M +
Sbjct: 2750 AGILEWFPRLRAMSLAAVDADGEQIELRSMQAQLLDTQLLIKNLSTQLHELKDHMTE 2806
Score = 547 bits (1410), Expect = e-153
Identities = 321/726 (44%), Positives = 439/726 (60%), Gaps = 11/726 (1%)
Frame = +1
Query: 94 GNNGNLHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFK 273
G+ LH+GDI+SLY E S GFLSTLGLVDDR +V + G PPKKFRDCL K
Sbjct: 7 GSASFLHLGDIVSLYAEGSVC----GFLSTLGLVDDRTVVCPEAGDLSCPPKKFRDCLIK 62
Query: 274 VCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQY 453
+CP+NRY+AQK W K Q+ S D +L+ +L AA+ E+++NE+E +K LG IQY
Sbjct: 63 ICPMNRYSAQKQFWKAAK--QSASSNTDPNLLKRLHHAAEIEKKQNETENKKLLGTSIQY 120
Query: 454 G-SMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNV 630
G ++VQLLH+KSNKY+TV K P+ E+NAM+VYLD GNEGSWF I+P YK +IGD V
Sbjct: 121 GRAVVQLLHLKSNKYLTVNKRLPSLLEKNAMRVYLDANGNEGSWFYIKPFYKLRSIGDYV 180
Query: 631 SAGNKISLIPNSVSTTQAGHVKSQLHLSS-FNLLDHQSAAEVNCLNEPTEWQVFMFLLFD 807
G+K+ L P + + LH+++ + L D+ EVN LN T W++ +F+
Sbjct: 181 VVGDKVILSPVNAD-------QQNLHVAANYELPDNPGCKEVNVLNSSTSWKISLFMEHK 233
Query: 808 ENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWE 987
ENQ++ +K GDVVRLFHA+Q+ FLT+D KQ VFLR T R SA ATSS+ALWE
Sbjct: 234 ENQEHILKGGDVVRLFHAEQEKFLTMDEYKKQYH----VFLRTTGRTSATAATSSKALWE 289
Query: 988 VQVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRRAS---LIYSKTN 1158
++VVQ ++ RGG WN YRFKHLAT YL+AE AM+ AS L +
Sbjct: 290 IEVVQHDSCRGGAGDWNSLYRFKHLATGHYLAAEAEIDVSAGAMSATSASGHDLHLGDCS 349
Query: 1159 NPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKE 1338
+ N N+ Q + SV P ++ +F LD +T + +
Sbjct: 350 KDSGLSCSTMNSTINDKPKGKQYRLVSV----PYSADIAS-----VFVLDATTMARPDSL 400
Query: 1339 VPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWVKVIC-EKNRVDKETFALLPV 1515
VP+ SYVRL H S+ WVHAT+ + + ++K + ++C + DKE FAL+PV
Sbjct: 401 VPQSSYVRLQHICSNTWVHATS------IPIDADDDKPVMSMVCCSPIKEDKEAFALIPV 454
Query: 1516 NPDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTN--SSDHLA 1689
+P EVRDLDFANDACK L + G + E + LL D + F+ + +
Sbjct: 455 SPVEVRDLDFANDACKVLATVTSKLDNGSISINER-RALISLLQDIVYFIAGMENEQNKT 513
Query: 1690 DPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNE 1869
L+ + +P RDRQKLLREQ +L Q+F +L+ PF Q T D +N
Sbjct: 514 KALEFTIKNPIRDRQKLLREQYILKQLFKILQGPF---QQHTAGDGPFLRLDELSDPKNS 570
Query: 1870 IFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLE 2049
+K +F+LCY +L+ SQ YRKNQE++A+ FG +Q+QIG+D++AEDT+TA+LHNN KLLE
Sbjct: 571 PYKNIFRLCYRILRLSQQDYRKNQEYIAKHFGLMQKQIGYDILAEDTITALLHNNRKLLE 630
Query: 2050 KYVKTPHVERFVELVRNNR---QGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDI 2220
K++ +E FV LVR N +FLDYL+DLCV +A QELIC SVLS K++DI
Sbjct: 631 KHITAAEIETFVGLVRKNMHNWDSRFLDYLSDLCVSNRKAIAVTQELICKSVLSDKNKDI 690
Query: 2221 FMDTKI 2238
++T++
Sbjct: 691 LIETQV 696
>gi|24644259|ref|NP_730941.1| CG1063-PB [Drosophila melanogaster]
gi|23170365|gb|AAN13240.1| CG1063-PB [Drosophila melanogaster]
Length = 2837
Score = 1122 bits (2901), Expect = 0.0
Identities = 757/2225 (34%), Positives = 1135/2225 (50%), Gaps = 132/2225 (5%)
Frame = +1
Query: 2248 EIEVGWA--PNFRKLVDIAEGAKSNSDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPER 2421
EI + W P R + D+A +A L+YYRHQL+L S MC +QYLA++
Sbjct: 762 EIHLKWTGQPTSRSMADLAS-CDGGELEAAILNYYRHQLNLFSNMCLNRQYLALN----- 815
Query: 2422 RLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLHLHVVRG--SPMSAIRHARLWWSI 2595
+S +L +L+L+CMSD +PY+LR SF RLMLHLHV R P++ +++ARLW I
Sbjct: 816 ---ELSPRLDIDLILKCMSDETMPYELRASFCRLMLHLHVDRDPQEPVTPVKYARLWSEI 872
Query: 2596 PENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATVETYLMGLRNQSMEERQSVNSSKL 2775
P +++ Y+ + + + R + +A VE YL + + +KL
Sbjct: 873 PSKMSIQDYDGKNQQPDQNKQACRAK---FNTTIAFVENYLCNVATKVWLFTDQ-EQNKL 928
Query: 2776 TYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINEGPATEQVPSHRAMVNAIRNMSKSMM 2955
T+E+V LA+ L F FYSF+DLL+LT+ LL+I++ T ++++ + +
Sbjct: 929 TFEVVKLARDLIYFGFYSFSDLLRLTKTLLSILDCVSDTSSGEFASTDIDSVEEETNAEA 988
Query: 2956 RGGNKENSKDL---------------AKTPSVTAEE---AGRTKEGRALNVKTKLIVAEI 3081
GG + D+ P+++ ++ + + L + TKL + EI
Sbjct: 989 EGGVLRSIGDINTVMTSLALGSVGQAIAAPTISLQQRKSVSQLMKEYPLVMDTKLKIIEI 1048
Query: 3082 LQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASE--------------- 3216
LQF++DVR DYRI+ LS FK F E + S +++ + +
Sbjct: 1049 LQFILDVRLDYRISCLLSIFKREFDESEVAASAASNEASQQQSQQQEPQTPGSSNETDPL 1108
Query: 3217 ----------------------------------LYDAIYRSSGHELHLDGRDGQLLLAI 3294
++D RS L LDG+ G+ L +
Sbjct: 1109 DSAESVAAGAAAAAATTARQKNIDLESIGVQAEGIFDC-ERSDAANLDLDGQGGRTFLRV 1167
Query: 3295 LLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILK 3474
LL + M DY PL S AL + FRHF+Q QE+L+ +QVQLLVS++DVE+Y+QI DL IL+
Sbjct: 1168 LLHLIMHDYAPLVSGALHLLFRHFSQRQEVLQAFRQVQLLVSDSDVESYKQIKSDLDILR 1227
Query: 3475 NLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNE 3654
EKSELWV+ K DE T D+G +L
Sbjct: 1228 QSVEKSELWVY-------KAKATDELGAT----------------DAGGDAVSLE----- 1259
Query: 3655 HYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGD 3834
N L ++ RN+ Y ++++L+R+ C
Sbjct: 1260 ------------YNAALSQEQRNE----------------YRKVKEILIRMNKFCVTASG 1291
Query: 3835 P----KPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKE 4002
P KP Q+LL+N+ V+ VVL+ + P+D+K D M +L+ L+HEFL++FC N++
Sbjct: 1292 PGSVVKPRKHEQRLLRNVGVHTVVLDLLQNPYDEKDDELMKELMCLAHEFLQNFCLGNQQ 1351
Query: 4003 NQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHN 4182
NQ L+ + + I E T+ AIF++N L + V ++++ H V IE +
Sbjct: 1352 NQVLLHNHLD--------LFLNPGILEAKTVCAIFKDNLALCNEVTDKVVQHFVHCIEIH 1403
Query: 4183 SRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEK 4362
R+ +L+ LQ +V ++ I Q+ V E+ + ++V Y D SF MM+ +
Sbjct: 1404 GRHVAYLQFLQTVVRAENQFIRRCQDMVMQELINSGEDVLVFYNDKGSFNHFVQMMQQQM 1463
Query: 4363 ESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEV 4542
+ SD LKYH+ELV+LLA CT GKN TE+KC + + +D IV ++ C+ EV
Sbjct: 1464 LRMEKLSDDS-PLKYHVELVKLLACCTMGKNVYTEIKCNNLLSLDDIVTIICHPLCMPEV 1522
Query: 4543 KTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILN-NLLEDIRSLRVEKLTGAETATLEHYI 4719
K Y+ L HCYIDT+ EMK+ Y + ++ + + L DI L + A TL+ Y+
Sbjct: 1523 KEAYVDFLNHCYIDTEVEMKEIYASGHMWSLFEKSFLVDINQL-ITNPAAASNKTLQAYV 1581
Query: 4720 CHTVTEVLIKFFEAPYS---ALQQAKVDVHHHKKTFSEVLLELTYLEKGKLRGSKSSRNW 4890
+ VT +L FF +P+S A+ Q++ + + + + +L G +
Sbjct: 1582 LNGVTNLLGSFFASPFSDQSAIVQSRQLIFVQLLQAAHRITQCRWLSLG---------DR 1632
Query: 4891 YRVAECIKRLTKWAEEHNITLPATLAGP--QMSGQTSVRQKWQQAASSAKWIGIGKRLNR 5064
+ V CI+ LT+ A+ +I LP L MS +T++ + + KW+ K+
Sbjct: 1633 FNVENCIRTLTESAKMRSIALPPELEQQVATMSSKTAMLTR-----QTTKWLLASKQ--- 1684
Query: 5065 QNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPEL 5244
P + ++ M S ++ ++ + L P+ AE S+LV++L+ EL
Sbjct: 1685 -----PKYEAQQAASLMRWDRS--IIEGLQDIVSLLEDQLKPVVEAELSLLVDILYRSEL 1737
Query: 5245 LFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKXXXXXXXX 5424
LFP G+ R +C GG + KLI+H + L++ K++ +C +VL+TL +M
Sbjct: 1738 LFPAGTEARKRCESGGFIRKLIKHTEKLLEEKEERMCVKVLRTLREMM-AIDVNYGEKGD 1796
Query: 5425 XXXXXXXXRYFGHHNNHHPPLDRQQSXXXXXXXXXXXXXXXTWSQE--------RDLYAI 5580
RYF + P D T + L+ +
Sbjct: 1797 ALRQTLLLRYFQTKSTPRLPEDEVPLLAAPLMDPAKQNHLVTHGPGAKYLQRAGKTLHEM 1856
Query: 5581 QCKLNDAGASDLVTDIIIMEP-SREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHE 5757
Q L+ GASDLV +++I S IF++A+ L ALL GN +Q + + D+++
Sbjct: 1857 QNHLDREGASDLVVELVIKSVHSPNIFVEAVELGIALLEGGNPIIQKGMFQKFLSDDLNQ 1916
Query: 5758 PFFKAILTRIQTAQNRLKSDMM--------SCSDSKPKVSLSATVSRR------SSTVLT 5895
FFK +++ AQ +KS + + K +L R + V+T
Sbjct: 1917 AFFKVFFEKMKDAQQEIKSTVTVNTTDIAAKAHEHKQDTNLELDKIARKHGLKSNGVVIT 1976
Query: 5896 P-----LIDAG--DTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKST 6054
L +AG G + +IS S L + L L ++D
Sbjct: 1977 EELKRELHNAGLATARAYGNARNIHSGEESSAISVNSPLEDILAEK---LEKHKDSRDQR 2033
Query: 6055 DALPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKG 6234
+ L +V +++PILR LQLLCENHN +QN LR Q+++TN+NLVSETL FLD +CGST G
Sbjct: 2034 NQLSNKVLVMQPILRFLQLLCENHNPDMQNLLRNQNNKTNNNLVSETLMFLDCICGSTTG 2093
Query: 6235 SLGVFG-EIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQE-NGLNIIISLVLNEIKP 6408
LG+ G I EHN +LI QTL LTE+CQGPCHENQN +A E NGL+II +L+LN I P
Sbjct: 2094 GLGLLGLYINEHNVALINQTLEALTEYCQGPCHENQNCIATHESNGLDIITALILNNINP 2153
Query: 6409 LADDHMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEM 6588
L ++ M+L LE+K+ ASKLLLAIMESR D ENA R+L NM PKQLV +AY
Sbjct: 2154 LGENRMDLVLELKNNASKLLLAIMESRGDSENAERILYNM-----NPKQLVEVACKAYHQ 2208
Query: 6589 TNSNHHMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSS 6768
+L + +D + +G
Sbjct: 2209 ------------EELIDEQDDGDEPDAG-------------------------------- 2224
Query: 6769 LDDKFNDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKK----DDLTREALN 6936
+DDD +V PREVGHNIYIL HQLA H+ EL L S++ + D T +AL
Sbjct: 2225 -----SDDDDATVSPREVGHNIYILCHQLAQHNKELAGLLKASEDPQSASFDAKTSQALM 2279
Query: 6937 YYKERTAQIEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEW 7116
YY TAQIEIVR DRTLE++VFPI +IC YLT DTK + N ERD+QGSKV +FFD+
Sbjct: 2280 YYATHTAQIEIVRNDRTLEQIVFPIPEICEYLTTDTKIKILNTAERDDQGSKVADFFDKA 2339
Query: 7117 ETMYHEMIWQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYP----LPEHSNS 7284
E M++EM WQ+KL+ + L W + + LW+ + F+ ++N +VA +YP +PE S S
Sbjct: 2340 EEMFNEMKWQKKLRSQPLLFWISSYMSLWSNILFNCVVVINMIVAFFYPFDNTVPELS-S 2398
Query: 7285 SISLGNLYSWFAVFSSFLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGI 7464
ISL L+ +FS ++ R I +G TL + G+
Sbjct: 2399 HISL--LFWIITIFSLVIVLALPRESGI------RTFIGSVILRFIFLLGPESTLCLLGV 2450
Query: 7465 LQLVNKIVHVVAFVSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFD 7644
+ + K VH+V+ + NKG ++ + +I+ L Y +Y+ C GL+ HP Y +LLFD
Sbjct: 2451 VTVTLKSVHIVSIMGNKGTLEKQLIKIITDFQLLYHCIYIAFCFCGLIFHPFFYSLLLFD 2510
Query: 7645 IIFTEETLQNVIASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSS 7824
+++ EETL NVI SVTRN +SIV T +LALIL+Y FSI+G+++F+ DF + VD E D++
Sbjct: 2511 VVYREETLVNVIRSVTRNGRSIVLTAVLALILVYLFSIIGYMFFKDDFLVSVDFEEQDNA 2570
Query: 7825 A------TISSGIPSETCPSEGCPG-----LQPSXXXXXXXXXXXXSCETLWMCILQTGY 7971
T+S + ++C + G + + SC++L MCI+ T
Sbjct: 2571 PPPSVPLTLSVPVSGDSCSAPDDLGNCQAAKEVAPPSAGGGEVKERSCDSLVMCIVTTLN 2630
Query: 7972 QGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTXXXXXXXXXXXXXXXXXXDTFGDLRAEK 8151
QGLRNGGGIGD+LR P+ E +F+ RV YD+ DTF DLR+EK
Sbjct: 2631 QGLRNGGGIGDILRAPSSKEGLFVARVIYDLLFFFIVIIIVLNLIFGVIIDTFADLRSEK 2690
Query: 8152 NEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPE 8331
+KE ILK CFIC L+RS FDN++V+FE H ++EHN+WHYLY+IV++++KD TEFTGPE
Sbjct: 2691 QQKEAILKTTCFICSLNRSAFDNKTVSFEEHIKSEHNMWHYLYFIVLVKVKDPTEFTGPE 2750
Query: 8332 SYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLLQMMTLMREIISQNEESR 8511
SYV VK L+WFPR++A+SL + D +Q E++ M+ QLL L++ + +Q E +
Sbjct: 2751 SYVYAMVKAGILEWFPRLRAMSLAAVDADGEQIELRSMQAQLLDTQLLIKNLSTQLHELK 2810
Query: 8512 AFMEQ 8526
M +
Sbjct: 2811 DHMTE 2815
Score = 547 bits (1410), Expect = e-153
Identities = 321/726 (44%), Positives = 439/726 (60%), Gaps = 11/726 (1%)
Frame = +1
Query: 94 GNNGNLHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFK 273
G+ LH+GDI+SLY E S GFLSTLGLVDDR +V + G PPKKFRDCL K
Sbjct: 7 GSASFLHLGDIVSLYAEGSVC----GFLSTLGLVDDRTVVCPEAGDLSCPPKKFRDCLIK 62
Query: 274 VCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQY 453
+CP+NRY+AQK W K Q+ S D +L+ +L AA+ E+++NE+E +K LG IQY
Sbjct: 63 ICPMNRYSAQKQFWKAAK--QSASSNTDPNLLKRLHHAAEIEKKQNETENKKLLGTSIQY 120
Query: 454 G-SMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNV 630
G ++VQLLH+KSNKY+TV K P+ E+NAM+VYLD GNEGSWF I+P YK +IGD V
Sbjct: 121 GRAVVQLLHLKSNKYLTVNKRLPSLLEKNAMRVYLDANGNEGSWFYIKPFYKLRSIGDYV 180
Query: 631 SAGNKISLIPNSVSTTQAGHVKSQLHLSS-FNLLDHQSAAEVNCLNEPTEWQVFMFLLFD 807
G+K+ L P + + LH+++ + L D+ EVN LN T W++ +F+
Sbjct: 181 VVGDKVILSPVNAD-------QQNLHVAANYELPDNPGCKEVNVLNSSTSWKISLFMEHK 233
Query: 808 ENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWE 987
ENQ++ +K GDVVRLFHA+Q+ FLT+D KQ VFLR T R SA ATSS+ALWE
Sbjct: 234 ENQEHILKGGDVVRLFHAEQEKFLTMDEYKKQYH----VFLRTTGRTSATAATSSKALWE 289
Query: 988 VQVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRRAS---LIYSKTN 1158
++VVQ ++ RGG WN YRFKHLAT YL+AE AM+ AS L +
Sbjct: 290 IEVVQHDSCRGGAGDWNSLYRFKHLATGHYLAAEAEIDVSAGAMSATSASGHDLHLGDCS 349
Query: 1159 NPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKE 1338
+ N N+ Q + SV P ++ +F LD +T + +
Sbjct: 350 KDSGLSCSTMNSTINDKPKGKQYRLVSV----PYSADIAS-----VFVLDATTMARPDSL 400
Query: 1339 VPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWVKVIC-EKNRVDKETFALLPV 1515
VP+ SYVRL H S+ WVHAT+ + + ++K + ++C + DKE FAL+PV
Sbjct: 401 VPQSSYVRLQHICSNTWVHATS------IPIDADDDKPVMSMVCCSPIKEDKEAFALIPV 454
Query: 1516 NPDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTN--SSDHLA 1689
+P EVRDLDFANDACK L + G + E + LL D + F+ + +
Sbjct: 455 SPVEVRDLDFANDACKVLATVTSKLDNGSISINER-RALISLLQDIVYFIAGMENEQNKT 513
Query: 1690 DPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNE 1869
L+ + +P RDRQKLLREQ +L Q+F +L+ PF Q T D +N
Sbjct: 514 KALEFTIKNPIRDRQKLLREQYILKQLFKILQGPF---QQHTAGDGPFLRLDELSDPKNS 570
Query: 1870 IFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLE 2049
+K +F+LCY +L+ SQ YRKNQE++A+ FG +Q+QIG+D++AEDT+TA+LHNN KLLE
Sbjct: 571 PYKNIFRLCYRILRLSQQDYRKNQEYIAKHFGLMQKQIGYDILAEDTITALLHNNRKLLE 630
Query: 2050 KYVKTPHVERFVELVRNNR---QGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDI 2220
K++ +E FV LVR N +FLDYL+DLCV +A QELIC SVLS K++DI
Sbjct: 631 KHITAAEIETFVGLVRKNMHNWDSRFLDYLSDLCVSNRKAIAVTQELICKSVLSDKNKDI 690
Query: 2221 FMDTKI 2238
++T++
Sbjct: 691 LIETQV 696
>gi|5689748|emb|CAB51853.1| inositol 1,4,5-trisphosphate receptor
[Drosophila melanogaster]
Length = 2828
Score = 1102 bits (2850), Expect = 0.0
Identities = 759/2218 (34%), Positives = 1138/2218 (51%), Gaps = 125/2218 (5%)
Frame = +1
Query: 2248 EIEVGWA--PNFRKLVDIAEGAKSNSDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPER 2421
EI + W P R + D+A +A L+YYRHQL+L S MC +QYLA++
Sbjct: 763 EIHLKWTGQPTSRSMADLAS-CDGGELEAAILNYYRHQLNLFSNMCLNRQYLALN----- 816
Query: 2422 RLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLHLHVVRG--SPMSAIRHARLWWSI 2595
+S +L +L+L+CMSD +PY+LR SF RLMLHLHV R P++ +++ARLW I
Sbjct: 817 ---ELSPRLDIDLILKCMSDETMPYELRASFCRLMLHLHVDRDPQEPVTPVKYARLWSEI 873
Query: 2596 PENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATVETYLMGLRNQSMEERQSVNSSKL 2775
P +++ Y+ + + + R + +A VE YL + + +KL
Sbjct: 874 PSKMSIQDYDGKNQQPDQNKQACRAK---FNTTIAFVENYLCNVATKVWLFTDQ-EQNKL 929
Query: 2776 TYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIIN------EGP-ATEQVPSHRAMVNAIR 2934
T+E+V LA+ L F FYSF+DLL+LT+ LL+I++ G A+ + S ++ +I
Sbjct: 930 TFEVVKLARDLIYFGFYSFSDLLRLTKTLLSILDCVSDTSSGEFASTDIDSEGGVLRSIG 989
Query: 2935 NMSKSMMRGGNKENSKDLAKTPSVTAEE---AGRTKEGRALNVKTKLIVAEILQFVMDVR 3105
+++ M + +A P+++ ++ + + L + TKL + EILQF++DVR
Sbjct: 990 DINTVMTSLALGSVGQAIA-APTISLQQRKSVSQLMKEYPLVMDTKLKIIEILQFILDVR 1048
Query: 3106 RDYRITMALSWFKNVF-----PCDEDGSLMHSASINER---------------------- 3204
DYRI+ LS FK F P S+S N R
Sbjct: 1049 LDYRISCLLSIFKREFDESEVPLRPLAMRQVSSSRNNRNRRRLAAPMRLIPSTVPSLWPP 1108
Query: 3205 ---------------------MASELYDAIYRSSGHELHLDGRDGQLLLAILLQMTMSDY 3321
A ++D RS L LDG+ G+ L +LL + M DY
Sbjct: 1109 RCAAAATTARQKNIDLESIGVQAEGIFDC-ERSDAANLDLDGQGGRTFLRVLLHLIMHDY 1167
Query: 3322 PPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELW 3501
PL S AL + FRHF+Q QE+L+ +QVQLLVS++DVE+Y+QI DL IL+ EKSELW
Sbjct: 1168 APLVSGALHLLFRHFSQRQEVLQAFRQVQLLVSDSDVESYKQIKSDLDILRQSVEKSELW 1227
Query: 3502 VHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNEC 3681
V+ K DE T D+G +L
Sbjct: 1228 VY-------KAKATDELGAT----------------DAGGDAVSLE-------------- 1250
Query: 3682 LQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDP----KPDT 3849
N L ++ RN+ Y ++++L+R+ C P KP
Sbjct: 1251 ---YNAALSQEQRNE----------------YRKVKEILIRMNKFCVTASGPGSVVKPRK 1291
Query: 3850 MNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFI 4029
Q+LL+N+ V+ VVL+ + P+D+K D M +L+ L+HEFL++FC N++NQ L+ +
Sbjct: 1292 HEQRLLRNVGVHTVVLDLLQNPYDEKDDELMKELMCLAHEFLQNFCLGNQQNQVLLHNHL 1351
Query: 4030 SYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEEL-IAH-IVGLIEHNSRNPIFL 4203
+ I E T+ AIF++N L + V +++ + H +V IE + R+ +L
Sbjct: 1352 D--------LFLNPGILEAKTVCAIFKDNLALCNEVTDKVGVGHSVVHCIEIHGRHVAYL 1403
Query: 4204 ELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSS 4383
+ LQ +V ++ I Q+ V E+ + ++V Y D SF MM+ + + S
Sbjct: 1404 QFLQTVVAAENQFIRRCQDMVMQELINSGEDVLVFYNDKGSFNHFVQMMQQQMLGMEKLS 1463
Query: 4384 DSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQL 4563
D LKYH+ELV+LLA CT GKN TE+KC + + +D IV ++ C+ EVK Y+
Sbjct: 1464 DDS-PLKYHVELVKLLACCTMGKNVYTEIKCNNLLSLDDIVTIICHPLCMPEVKEAYVDF 1522
Query: 4564 LLHCYIDTDAEMKDAYKTEYVDHILN-NLLEDIRSLRVEKLTGAETATLEHYICHTVTEV 4740
L HCYIDT+ EMK+ Y + ++ + + L DI L + A TL+ Y+ + VT +
Sbjct: 1523 LNHCYIDTEVEMKEIYASGHMWSLFEKSFLVDINQL-ITNPAAASNKTLQAYVLNGVTNL 1581
Query: 4741 LIKFFEAPYS---ALQQAKVDVHHHKKTFSEVLLELTYLEKGKLRGSKSSRNWYRVAECI 4911
L FF +P+S A+ Q++ + + + + +L G + + V CI
Sbjct: 1582 LGSFFASPFSDQSAIVQSRQLIFVQLLQAAHRITQCRWLSLG---------DRFNVENCI 1632
Query: 4912 KRLTKWAEEHNITLPATLAGP--QMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPG 5085
+ LT+ A+ +I LP L MS +T++ + + KW+ K+ P
Sbjct: 1633 RTLTESAKMRSIALPPELEQQVATMSSKTAMLTR-----QTTKWLLASKQ--------PK 1679
Query: 5086 HRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSA 5265
+ ++ M S ++ ++ + L P+ AE S+LV++L+ ELLFP G+
Sbjct: 1680 YEAQQAASLMRWDRS--IIEGLQDIVSLLEDQLKPVVEAELSLLVDILYRSELLFPAGTE 1737
Query: 5266 LRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKXXXXXXXXXXXXXXX 5445
R +C GG + KLI+H + L++ K++ +C +VL+TL +M
Sbjct: 1738 ARKRCESGGFIRKLIKHTEKLLEEKEERMCVKVLRTLREMM-AIDVNYGEKGDALRQTLL 1796
Query: 5446 XRYFGHHNNHHPPLDRQQSXXXXXXXXXXXXXXXTWSQE--------RDLYAIQCKLNDA 5601
RYF + P D T + L+ +Q L+
Sbjct: 1797 LRYFQTKSTPRLPEDEVPLLAAPLMDPAKQNHLVTHGPGAKYLQRAGKTLHEMQNHLDRE 1856
Query: 5602 GASDLVTDIIIMEP-SREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEPFFKAIL 5778
GASDLV +++I S IF++A+ L ALL GN +Q + + D+++ FFK
Sbjct: 1857 GASDLVVELVIKSVHSPNIFVEAVELGIALLEGGNPIIQKGMFQKFLSDDLNQAFFKVFF 1916
Query: 5779 TRIQTAQNRLKSDMM--------SCSDSKPKVSLSATVSRR------SSTVLTP-----L 5901
+++ AQ +KS + + K +L R + V+T L
Sbjct: 1917 EKMKDAQQEIKSTVTVNTTDIAAKAHEHKQDTNLELDKIARKHGLKSNGVVITEELKREL 1976
Query: 5902 IDAG--DTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPEV 6075
+AG G + +IS S L + L L ++D + L +V
Sbjct: 1977 HNAGLATARAYGNARNIHSGEESSAISVNSPLEDILAEK---LEKHKDSRDQRNQLSNKV 2033
Query: 6076 ALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFG- 6252
+++PILR LQLLCENHN +QN LR Q+++TN+NLVSETL FLD +CGST G LG+ G
Sbjct: 2034 LVMQPILRFLQLLCENHNPDMQNLLRNQNNKTNNNLVSETLMFLDCICGSTTGGLGLLGL 2093
Query: 6253 EIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQE-NGLNIIISLVLNEIKPLADDHME 6429
I EHN +LI QTL LTE+CQGPCHENQN +A E NGL+II +L+LN I PL ++ M+
Sbjct: 2094 YINEHNLALINQTLEALTEYCQGPCHENQNCIATHESNGLDIITALILNNINPLGENRMD 2153
Query: 6430 LALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHM 6609
L LE+K+ ASKLLLAIMESR D ENA R+L NM PKQLV +AY
Sbjct: 2154 LVLELKNNASKLLLAIMESRGDSENAERILYNM-----NPKQLVEVACKAYHQ------- 2201
Query: 6610 LKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFND 6789
+L + +D + +G +D
Sbjct: 2202 -----EELIDEQDDGDEPDAG-------------------------------------SD 2219
Query: 6790 DDIPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKK----DDLTREALNYYKERTA 6957
DD +V PREVGHNIYIL HQLA H+ EL L S++ + D T +AL YY TA
Sbjct: 2220 DDDATVSPREVGHNIYILCHQLAQHNKELAGLLKASEDPQSASFDAKTSQALMYYATHTA 2279
Query: 6958 QIEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEM 7137
QIEIVR DRTLE++VFPI +IC YLT DTK + N ERD+QGSK+ +FFD+ E M++EM
Sbjct: 2280 QIEIVRNDRTLEQIVFPIPEICEYLTTDTKIKILNTAERDDQGSKLADFFDKAEEMFNEM 2339
Query: 7138 IWQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYP----LPEHSNSSISLGNL 7305
WQ+KL+ + L W + + LW+ + F+ ++N +VA +YP +PE S S ISL L
Sbjct: 2340 KWQKKLRSQPLLFWISSYMSLWSNILFNCVVVINMIVAFFYPFDNTVPELS-SHISL--L 2396
Query: 7306 YSWFAVFSSFLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKI 7485
+ +FS ++ R I +G TL + G++ + K
Sbjct: 2397 FWIITIFSLVIVLALPRESGI------RTFIGSVILRFIFLLGPESTLCLLGVVTVTLKS 2450
Query: 7486 VHVVAFVSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEET 7665
VH+V+ + NKG ++ + +I+ + + L + +L L+ HP Y +LLFD+++ EET
Sbjct: 2451 VHIVSIMGNKGTLEKQLIKIITDFSTYTALYS--VLLLRLIFHPFFYSLLLFDVVYREET 2508
Query: 7666 LQNVIASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSA------ 7827
L NVI SVTRN +SIV T +LALIL+Y FSI+G+++F+ DF + VD E D++
Sbjct: 2509 LVNVIRSVTRNGRSIVLTAVLALILVYLFSIIGYMFFKDDFLVSVDFEEQDNAPPPSVPL 2568
Query: 7828 TISSGIPSETCPSEGCPG-----LQPSXXXXXXXXXXXXSCETLWMCILQTGYQGLRNGG 7992
T+S + ++C + G + + SC++L MCI+ T QGLRNGG
Sbjct: 2569 TLSVPVSGDSCSAPDDLGNCQAAKEVAPPSAGGGEVKERSCDSLVMCIVTTLNQGLRNGG 2628
Query: 7993 GIGDVLRNPAPWEDMFIWRVAYDMTXXXXXXXXXXXXXXXXXXDTFGDLRAEKNEKEQIL 8172
GIGD+LR P+ E +F+ RV YD+ DTF DLR+EK +KE IL
Sbjct: 2629 GIGDILRAPSSKEGLFVARVIYDLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQQKEAIL 2688
Query: 8173 KNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCV 8352
K CFIC L+RS FDN++V+FE H ++EHN+WHYLY+IV++++KD TEFTGPESYV V
Sbjct: 2689 KTTCFICSLNRSAFDNKTVSFEEHIKSEHNMWHYLYFIVLVKVKDPTEFTGPESYVYAMV 2748
Query: 8353 KDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLLQMMTLMREIISQNEESRAFMEQ 8526
K L+WFPR++A+SL + D +Q E++ M+ QLL L++ + +Q E + M +
Sbjct: 2749 KAGILEWFPRLRAMSLAAVDADGEQIELRSMQAQLLDTQLLIKNLSTQLHELKDHMTE 2806
Score = 543 bits (1398), Expect = e-152
Identities = 321/727 (44%), Positives = 439/727 (60%), Gaps = 12/727 (1%)
Frame = +1
Query: 94 GNNGNLHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFK 273
G+ LH+GDI+SLY E S GFLSTLGLVDDR +V + G PPKKFRDCL K
Sbjct: 7 GSASFLHLGDIVSLYAEGSVC----GFLSTLGLVDDRTVVCPEAGDLSCPPKKFRDCLIK 62
Query: 274 VCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQY 453
+CP+NRY+AQK W K Q+ S D +L+ +L AA+ E+++NE+E +K LG IQY
Sbjct: 63 ICPMNRYSAQKQFWKAAK--QSASSNTDPNLLKRLHHAAEIEKKQNETENKKLLGTSIQY 120
Query: 454 G-SMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNV 630
G ++VQLLH+KSNKY+TV K P+ E+NAM+VYLD GNEGSWF I+P YK +IGD V
Sbjct: 121 GRAVVQLLHLKSNKYLTVNKRLPSLLEKNAMRVYLDANGNEGSWFYIKPFYKLRSIGDYV 180
Query: 631 SA-GNKISLIPNSVSTTQAGHVKSQLHLSS-FNLLDHQSAAEVNCLNEPTEWQVFMFLLF 804
G+K+ L P + + LH+++ + L D+ EVN LN T W++ +F+
Sbjct: 181 VVVGDKVILSPVNAD-------QQNLHVAANYELPDNPGCKEVNVLNSSTSWKISLFMEH 233
Query: 805 DENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALW 984
ENQ++ +K GDVVRLFHA+Q+ FLT+D KQ VFLR T R SA ATSS+ALW
Sbjct: 234 KENQEHILKGGDVVRLFHAEQEKFLTMDEYKKQYH----VFLRTTGRTSATAATSSKALW 289
Query: 985 EVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRRAS---LIYSKT 1155
E++VVQ ++ RGG WN YRFKHLAT YL+AE AM+ AS L
Sbjct: 290 EIEVVQHDSCRGGAGDWNSLYRFKHLATGHYLAAEAEIDVSAGAMSATSASGHDLHLGDC 349
Query: 1156 NNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNK 1335
+ + N N+ Q + SV P ++ +F LD +T + +
Sbjct: 350 SKDSGLSCSTMNSTINDKPKGKQYRLVSV----PYSADIAS-----VFVLDATTMARPDS 400
Query: 1336 EVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWVKVIC-EKNRVDKETFALLP 1512
VP+ SYVRL H S+ WVHAT+ + + ++K + ++C + DKE FAL+P
Sbjct: 401 LVPQSSYVRLQHICSNTWVHATS------IPIDADDDKPVMSMVCCSPIKEDKEAFALIP 454
Query: 1513 VNPDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTN--SSDHL 1686
V+P EVRDLDFANDACK L + G + E + LL D + F+ + +
Sbjct: 455 VSPVEVRDLDFANDACKVLATVTSKLDNGSISINER-RALISLLQDIVYFIAGMENEQNK 513
Query: 1687 ADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRN 1866
L+ + +P RDRQKLLREQ +L Q+F +L+ PF Q T D +N
Sbjct: 514 TKALEFTIKNPIRDRQKLLREQYILKQLFKILQGPF---QEHTAGDGPFLRLDELSDPKN 570
Query: 1867 EIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLL 2046
+K +F+LCY +L+ SQ YRKNQE++A+ FG +Q+QIG+D++AEDT+TA+LHNN KLL
Sbjct: 571 SPYKNIFRLCYRILRLSQQDYRKNQEYIAKHFGLMQKQIGYDILAEDTITALLHNNRKLL 630
Query: 2047 EKYVKTPHVERFVELVRNNR---QGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRD 2217
EK++ +E FV LVR N +FLDYL+DLCV +A QELIC SVLS K++D
Sbjct: 631 EKHITAAEIETFVGLVRKNMHNWDSRFLDYLSDLCVSNRKAIAVTQELICKSVLSDKNKD 690
Query: 2218 IFMDTKI 2238
I ++T++
Sbjct: 691 ILIETQV 697
>gi|345496|pir||A43360 inositol 1,4,5-trisphosphate receptor - fruit
fly (Drosophila melanogaster)
gi|217338|dbj|BAA14399.1| inositol 1,4,5-trisphosphate receptor
[Drosophila melanogaster]
Length = 2833
Score = 1100 bits (2845), Expect = 0.0
Identities = 755/2224 (33%), Positives = 1132/2224 (49%), Gaps = 131/2224 (5%)
Frame = +1
Query: 2248 EIEVGWA--PNFRKLVDIAEGAKSNSDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPER 2421
EI + W P R + D+A +A L+YYRHQL+L S MC +QYLA++
Sbjct: 763 EIHLKWTGQPTSRSMADLAS-CDGGELEAAILNYYRHQLNLFSNMCLNRQYLALN----- 816
Query: 2422 RLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLHLHVVRG--SPMSAIRHARLWWSI 2595
+S +L +L+L+CMSD +PY+LR SF RLMLHLHV R P++ +++ARLW I
Sbjct: 817 ---ELSPRLDIDLILKCMSDETMPYELRASFCRLMLHLHVDRDPQEPVTPVKYARLWSEI 873
Query: 2596 PENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATVETYLMGLRNQSMEERQSVNSSKL 2775
P +++ Y+ + + + R + +A VE YL + + +KL
Sbjct: 874 PSKMSIQDYDGKNQQPDQNKQACRAK---FNTTIAFVENYLCNVATKVWLFTDQ-EQNKL 929
Query: 2776 TYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINEGPATEQVPSHRAMVNAIRNMSKSMM 2955
T+E+V LA+ L F FYSF+DLL+LT+ LL+I++ T ++++ + +
Sbjct: 930 TFEVVKLARDLIYFGFYSFSDLLRLTKTLLSILDCVSDTSSGEFASTDIDSVEEETNAEA 989
Query: 2956 RGGNKENSKDL---------------AKTPSVTAEE---AGRTKEGRALNVKTKLIVAEI 3081
GG + D+ P+++ ++ + + L + TKL + EI
Sbjct: 990 EGGVLRSIGDINTVMTSLALGSVGQAIAAPTISLQQRKSVSQLMKEYPLVMDTKLKIIEI 1049
Query: 3082 LQFVMDVRRDYRITMALSWFKNVF-----PCDEDGSLMHSASINER-------------- 3204
LQF++DVR DYRI+ LS FK F P S+S N R
Sbjct: 1050 LQFILDVRLDYRISCLLSIFKREFDESEVPLRPLAMRQVSSSRNNRNRRRLAAPMRLIPS 1109
Query: 3205 -----------------------------MASELYDAIYRSSGHELHLDGRDGQLLLAIL 3297
A ++D + L LDG+ G+ L +L
Sbjct: 1110 TVPSLWPPRCAAAATTARQKNIDLESIGVQAEGIFDC--ERTPANLDLDGQGGRTFLRVL 1167
Query: 3298 LQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKN 3477
L + M DY PL S AL + FRHF+Q QE+L+ +QVQLLVS++DVE+Y+QI DL IL+
Sbjct: 1168 LHLIMHDYAPLVSGALHLLFRHFSQRQEVLQAFRQVQLLVSDSDVESYKQIKSDLDILRQ 1227
Query: 3478 LTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEH 3657
EKSELWV+ K DE T D+G +L
Sbjct: 1228 SVEKSELWVY-------KAKATDELGAT----------------DAGGDAVSLE------ 1258
Query: 3658 YPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDP 3837
N L ++ RN+ Y ++++L+R+ C P
Sbjct: 1259 -----------YNAALSQEQRNE----------------YRKVKEILIRMNKFCVTASGP 1291
Query: 3838 ----KPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKEN 4005
KP Q+LL+N+ V+ VVL+ + P+D+K D M +L+ L+HEFL++FC N++N
Sbjct: 1292 GSVVKPRKHEQRLLRNVGVHTVVLDLLQNPYDEKDDELMKELMCLAHEFLQNFCLGNQQN 1351
Query: 4006 QSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNS 4185
Q L+ + + I E T+ AIF++N L + V ++++ H V IE +
Sbjct: 1352 QVLLHNHLD--------LFLNPGILEAKTVCAIFKDNLALCNEVTDKVV-HFVHCIEIHG 1402
Query: 4186 RNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKE 4365
R+ +L+ LQ +V ++ I Q+ V E+ + ++V Y D SF MM+ +
Sbjct: 1403 RHVAYLQFLQTVVAAENQFIRRCQDMVMQELINSGEDVLVFYNDKGSFNHFVQMMQQQML 1462
Query: 4366 SKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVK 4545
+ SD LKYH+ELV+LLA CT GKN TE+KC + + +D IV ++ C+ EVK
Sbjct: 1463 GMEKLSDDS-PLKYHVELVKLLACCTMGKNVYTEIKCNNLLSLDDIVTIICHPLCMPEVK 1521
Query: 4546 TVYLQLLLHCYIDTDAEMKDAYKTEYVDHILN-NLLEDIRSLRVEKLTGAETATLEHYIC 4722
Y+ L HCYIDT+ EMK+ Y + ++ + + L DI L + A TL+ Y+
Sbjct: 1522 EAYVDFLNHCYIDTEVEMKEIYASGHMWSLFEKSFLVDINQL-ITNPAAASNKTLQAYVL 1580
Query: 4723 HTVTEVLIKFFEAPYS---ALQQAKVDVHHHKKTFSEVLLELTYLEKGKLRGSKSSRNWY 4893
+ VT +L FF +P+S A+ Q++ + + + + +L G + +
Sbjct: 1581 NGVTNLLGSFFASPFSDQSAIVQSRQLIFVQLLQAAHRITQCRWLSLG---------DRF 1631
Query: 4894 RVAECIKRLTKWAEEHNITLPATLAGP--QMSGQTSVRQKWQQAASSAKWIGIGKRLNRQ 5067
V CI+ LT+ A+ +I LP L MS +T++ + + KW+ K+
Sbjct: 1632 NVENCIRTLTESAKMRSIALPPELEQQVATMSSKTAMLTR-----QTTKWLLASKQ---- 1682
Query: 5068 NTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELL 5247
P + ++ M S ++ ++ + L P+ AE S+LV++L+ ELL
Sbjct: 1683 ----PKYEAQQAASLMRWDRS--IIEGLQDIVSLLEDQLKPVVEAELSLLVDILYRSELL 1736
Query: 5248 FPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKXXXXXXXXX 5427
FP G+ R +C GG + KLI+H + L++ K++ +C +VL+TL +M
Sbjct: 1737 FPAGTEARKRCESGGFIRKLIKHTEKLLEEKEERMCVKVLRTLREMM-AIDVNYGEKGDA 1795
Query: 5428 XXXXXXXRYFGHHNNHHPPLDRQQSXXXXXXXXXXXXXXXTWSQE--------RDLYAIQ 5583
RYF + P D T + L+ +Q
Sbjct: 1796 LRQTLLLRYFQTKSTPRLPEDEVPLLAAPLMDPAKQNHLVTHGPGAKYLQRAGKTLHEMQ 1855
Query: 5584 CKLNDAGASDLVTDIIIMEP-SREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEP 5760
L+ GASDLV +++I S IF++A+ L ALL GN +Q + + D+++
Sbjct: 1856 NHLDREGASDLVVELVIKSVHSPNIFVEAVELGIALLEGGNPIIQKGMFQKFLSDDLNQA 1915
Query: 5761 FFKAILTRIQTAQNRLKSDMM--------SCSDSKPKVSLSATVSRR------SSTVLTP 5898
FFK +++ AQ +KS + + K +L R + V+T
Sbjct: 1916 FFKVFFEKMKDAQQEIKSTVTVNTTDIAAKAHEHKQDTNLELDKIARKHGLKSNGVVITE 1975
Query: 5899 -----LIDAG--DTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTD 6057
L +AG G + +IS S L + L L ++D +
Sbjct: 1976 ELKRELHNAGLATARAYGNARNIHSGEESSAISVNSPLEDILAEK---LEKHKDSRDQRN 2032
Query: 6058 ALPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGS 6237
L +V +++PILR LQLLCENHN +QN LR Q+++TN+NLVSETL FLD +CGST G
Sbjct: 2033 QLSNKVLVMQPILRFLQLLCENHNPDMQNLLRNQNNKTNNNLVSETLMFLDCICGSTTGG 2092
Query: 6238 LGVFG-EIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQE-NGLNIIISLVLNEIKPL 6411
LG+ G I EHN +LI QTL LTE+CQGPCHENQN +A E NGL+II +L+LN I PL
Sbjct: 2093 LGLLGLYINEHNLALINQTLEALTEYCQGPCHENQNCIATHESNGLDIITALILNNINPL 2152
Query: 6412 ADDHMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMT 6591
++ M+L LE+K+ ASKLLLAIMESR D ENA R+L NM PKQLV +AY
Sbjct: 2153 GENRMDLVLELKNNASKLLLAIMESRGDSENAERILYNM-----NPKQLVEVACKAYHQ- 2206
Query: 6592 NSNHHMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSL 6771
+L + +D + +G
Sbjct: 2207 -----------EELIDEQDDGDEPDAG--------------------------------- 2222
Query: 6772 DDKFNDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKK----DDLTREALNY 6939
+DDD +V PREVGHNIYIL HQLA H+ EL L S++ + D T +AL Y
Sbjct: 2223 ----SDDDDATVSPREVGHNIYILCHQLAQHNKELAGLLKASEDPQSASFDAKTSQALMY 2278
Query: 6940 YKERTAQIEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWE 7119
Y TAQIEIVR DRTLE++VFPI +IC YLT DTK + N ERD+QGSK+ +FFD+ E
Sbjct: 2279 YATHTAQIEIVRNDRTLEQIVFPIPEICEYLTTDTKIKILNTAERDDQGSKLADFFDKAE 2338
Query: 7120 TMYHEMIWQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYP----LPEHSNSS 7287
M++EM WQ+KL+ + L W + + LW+ + F+ ++N +VA +YP +PE S S
Sbjct: 2339 EMFNEMKWQKKLRSQPLLFWISSYMSLWSNILFNCVVVINMIVAFFYPFDNTVPELS-SH 2397
Query: 7288 ISLGNLYSWFAVFSSFLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGIL 7467
ISL L+ +FS ++ R I +G TL + G++
Sbjct: 2398 ISL--LFWIITIFSLVIVLALPRESGI------RTFIGSVILRFIFLLGPESTLCLLGVV 2449
Query: 7468 QLVNKIVHVVAFVSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDI 7647
+ K VH+V+ + NKG ++ + +I+ + + L + +L L+ HP Y +LLFD+
Sbjct: 2450 TVTLKSVHIVSIMGNKGTLEKQLIKIITDFSTYTALYS--VLLLRLIFHPFFYSLLLFDV 2507
Query: 7648 IFTEETLQNVIASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSA 7827
++ EETL NVI SVTRN +SIV T +LALIL+Y FSI+G+++F+ DF + VD E D++
Sbjct: 2508 VYREETLVNVIRSVTRNGRSIVLTAVLALILVYLFSIIGYMFFKDDFLVSVDFEEQDNAP 2567
Query: 7828 ------TISSGIPSETCPSEGCPG-----LQPSXXXXXXXXXXXXSCETLWMCILQTGYQ 7974
T+S + ++C + G + + SC++L MCI+ T Q
Sbjct: 2568 PPSVPLTLSVPVSGDSCSAPDDLGNCQAAKEVAPPSAGGGEVKERSCDSLVMCIVTTLNQ 2627
Query: 7975 GLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTXXXXXXXXXXXXXXXXXXDTFGDLRAEKN 8154
GLRNGGGIGD+LR P+ E +F+ RV YD+ DTF DLR+EK
Sbjct: 2628 GLRNGGGIGDILRAPSSKEGLFVARVIYDLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQ 2687
Query: 8155 EKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPES 8334
+KE ILK CFIC L+RS FDN++V+FE H ++EHN+WHYLY+IV++++KD TEFTGPES
Sbjct: 2688 QKEAILKTTCFICSLNRSAFDNKTVSFEEHIKSEHNMWHYLYFIVLVKVKDPTEFTGPES 2747
Query: 8335 YVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLLQMMTLMREIISQNEESRA 8514
YV VK L+WFPR++A+SL + D +Q E++ M+ QLL L++ + +Q E +
Sbjct: 2748 YVYAMVKAGILEWFPRLRAMSLAAVDADGEQIELRSMQAQLLDTQLLIKFLSTQLHELKD 2807
Query: 8515 FMEQ 8526
M +
Sbjct: 2808 HMTE 2811
Score = 543 bits (1398), Expect = e-152
Identities = 321/727 (44%), Positives = 439/727 (60%), Gaps = 12/727 (1%)
Frame = +1
Query: 94 GNNGNLHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFK 273
G+ LH+GDI+SLY E S GFLSTLGLVDDR +V + G PPKKFRDCL K
Sbjct: 7 GSASFLHLGDIVSLYAEGSVC----GFLSTLGLVDDRTVVCPEAGDLSCPPKKFRDCLIK 62
Query: 274 VCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQY 453
+CP+NRY+AQK W K Q+ S D +L+ +L AA+ E+++NE+E +K LG IQY
Sbjct: 63 ICPMNRYSAQKQFWKAAK--QSASSNTDPNLLKRLHHAAEIEKKQNETENKKLLGTSIQY 120
Query: 454 G-SMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNV 630
G ++VQLLH+KSNKY+TV K P+ E+NAM+VYLD GNEGSWF I+P YK +IGD V
Sbjct: 121 GRAVVQLLHLKSNKYLTVNKRLPSLLEKNAMRVYLDANGNEGSWFYIKPFYKLRSIGDYV 180
Query: 631 SA-GNKISLIPNSVSTTQAGHVKSQLHLSS-FNLLDHQSAAEVNCLNEPTEWQVFMFLLF 804
G+K+ L P + + LH+++ + L D+ EVN LN T W++ +F+
Sbjct: 181 VVVGDKVILSPVNAD-------QQNLHVAANYELPDNPGCKEVNVLNSSTSWKISLFMEH 233
Query: 805 DENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALW 984
ENQ++ +K GDVVRLFHA+Q+ FLT+D KQ VFLR T R SA ATSS+ALW
Sbjct: 234 KENQEHILKGGDVVRLFHAEQEKFLTMDEYKKQYH----VFLRTTGRTSATAATSSKALW 289
Query: 985 EVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRRAS---LIYSKT 1155
E++VVQ ++ RGG WN YRFKHLAT YL+AE AM+ AS L
Sbjct: 290 EIEVVQHDSCRGGAGDWNSLYRFKHLATGHYLAAEAEIDVSAGAMSATSASGHDLHLGDC 349
Query: 1156 NNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNK 1335
+ + N N+ Q + SV P ++ +F LD +T + +
Sbjct: 350 SKDSGLSCSTMNSTINDKPKGKQYRLVSV----PYSADIAS-----VFVLDATTMARPDS 400
Query: 1336 EVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWVKVIC-EKNRVDKETFALLP 1512
VP+ SYVRL H S+ WVHAT+ + + ++K + ++C + DKE FAL+P
Sbjct: 401 LVPQSSYVRLQHICSNTWVHATS------IPIDADDDKPVMSMVCCSPIKEDKEAFALIP 454
Query: 1513 VNPDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTN--SSDHL 1686
V+P EVRDLDFANDACK L + G + E + LL D + F+ + +
Sbjct: 455 VSPVEVRDLDFANDACKVLATVTSKLDNGSISINER-RALISLLQDIVYFIAGMENEQNK 513
Query: 1687 ADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRN 1866
L+ + +P RDRQKLLREQ +L Q+F +L+ PF Q T D +N
Sbjct: 514 TKALEFTIKNPIRDRQKLLREQYILKQLFKILQGPF---QEHTAGDGPFLRLDELSDPKN 570
Query: 1867 EIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLL 2046
+K +F+LCY +L+ SQ YRKNQE++A+ FG +Q+QIG+D++AEDT+TA+LHNN KLL
Sbjct: 571 SPYKNIFRLCYRILRLSQQDYRKNQEYIAKHFGLMQKQIGYDILAEDTITALLHNNRKLL 630
Query: 2047 EKYVKTPHVERFVELVRNNR---QGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRD 2217
EK++ +E FV LVR N +FLDYL+DLCV +A QELIC SVLS K++D
Sbjct: 631 EKHITAAEIETFVGLVRKNMHNWDSRFLDYLSDLCVSNRKAIAVTQELICKSVLSDKNKD 690
Query: 2218 IFMDTKI 2238
I ++T++
Sbjct: 691 ILIETQV 697
>gi|111839|pir||B36579 inositol 1,4,5-triphosphate receptor 2 - rat
gi|204674|gb|AAA41357.1| inositol-1,4,5-triphosphate receptor
Length = 2734
Score = 1060 bits (2741), Expect = 0.0
Identities = 673/1825 (36%), Positives = 994/1825 (53%), Gaps = 66/1825 (3%)
Frame = +1
Query: 109 LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
LHIGDI SLY E S+N GF+STLGLVDDRC+V+ + G +PPKKFRDCLFK+CP+N
Sbjct: 9 LHIGDICSLYAEGSTN----GFISTLGLVDDRCVVQPEAGDLNNPPKKFRDCLFKLCPMN 64
Query: 289 RYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQ 468
RY+AQK W K +S D L+NKL AAD E+++NE+E +K LG VIQYG+++Q
Sbjct: 65 RYSAQKQFWKAAK--PGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQ 122
Query: 469 LLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKI 648
LLH+KSNKY+TV K PA E+NAM+V LD AGNEGSWF I+P YK +IGD+V G+K+
Sbjct: 123 LLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGDKV 182
Query: 649 SLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSV 828
L P AG LH SS L+D+ EVN +N T W++ +F+ + +N+ + +
Sbjct: 183 VLNP-----VNAG---QPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDIL 234
Query: 829 KSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTN 1008
K GDVVRLFHA+Q+ FLT D K+ VFLR T R SA ATSS+ALWEV+VVQ +
Sbjct: 235 KGGDVVRLFHAEQEKFLTCDEHRKKQH----VFLRTTGRQSATSATSSKALWEVEVVQHD 290
Query: 1009 AYRGGTAKWNKAYRFKHLATDMYLSAE--PSQVQVKPAMNGRRASLIYSKTNNPMAMYSD 1182
RGG WN +RFKHLAT YL+AE P Q + + + ++YS + P
Sbjct: 291 PCRGGAGYWNSLFRFKHLATGHYLAAEVDPDQDASRSRLRNAQEKMVYSLVSVPEG---- 346
Query: 1183 GPNGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVR 1362
D + +F+LDP+T + VPR SYVR
Sbjct: 347 --------------------------------NDISSIFELDPTTLRGGDSLVPRNSYVR 374
Query: 1363 LLHQSSDKWVHATNATEKQNLHYSSKNEKG-WVKVICEKNRVDKETFALLPVNPDEVRDL 1539
L H ++ WVH+T N+ + EK +K+ + DKE FA++PV+P EVRDL
Sbjct: 375 LRHLCTNTWVHST------NIPIDKEEEKPVMLKIGTSPLKEDKEAFAIVPVSPAEVRDL 428
Query: 1540 DFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSP 1719
DFANDA K L + ++ G + E S T+LL D + FVT ++ D L++ P
Sbjct: 429 DFANDASKVLGSIAGKLEKGTITQNER-RSVTKLLEDLVYFVTGGTNSGQDVLEVVFSKP 487
Query: 1720 SRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIFKTMFQLCY 1899
+R+RQKL+REQ +L Q+F LL+APF T D R+ F+ + +LCY
Sbjct: 488 NRERQKLMREQNILKQIFKLLQAPF-----TDCGDGPMLRLEELGDQRHAPFRHICRLCY 542
Query: 1900 CLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVER 2079
+L++SQ YRKNQE++A++FG +Q+QIG+D++AEDT+TA+LHNN KLLEK++ ++
Sbjct: 543 RVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKHITAAEIDT 602
Query: 2080 FVELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKII------ 2241
FV LVR NR+ +FLDYL+DLCV ++ QELIC +VL+ + DI ++TK++
Sbjct: 603 FVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETKLVLSRFEF 662
Query: 2242 ---------------DGEIEVGWAPNFRKL-----VDIAEGAK-SNSDDAEHLDYYRHQL 2358
+ E+ + W + +++ ++A+ AK +D + L YYR+QL
Sbjct: 663 EGVSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDAKEGQKEDRDVLSYYRYQL 722
Query: 2359 DLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLHLH 2538
+L ++MC ++QYLAI+ IS QL +L+L+CMSD LPYDLR SF RLMLH+H
Sbjct: 723 NLFARMCLDRQYLAIN--------EISGQLDVDLILRCMSDENLPYDLRASFCRLMLHMH 774
Query: 2539 VVRG--SPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATVET 2712
V R ++ +++ARLW IP + + Y+S S S+ I E A + + VE
Sbjct: 775 VDRDPQEQVTPVKYARLWSEIPSEIAIDDYDS------SGASKDEIKERFA-QTMEFVEE 827
Query: 2713 YLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINEGPAT 2892
YL + Q +KLT+E+VNLA+ L F FY+F+DLL+LT+ LLAI++ T
Sbjct: 828 YLRDVVCQRFPFSDK-EKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCVHVT 886
Query: 2893 EQVPSHRAM-------VNAIRN-------MSKSMMRGGNKENSKDLAKTPSVTAEEAGRT 3030
P + N +R+ M++ ++RGG +A P ++A
Sbjct: 887 TIFPISKMTKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEGNVKQAEPE 946
Query: 3031 KEGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFP-------------CDEDG 3171
KE + + TKL + EILQF+++VR DYRI+ L FK F ++G
Sbjct: 947 KED-IMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQSSETSSGNSSQEG 1005
Query: 3172 SLMHSASINERMASELYDAIYRSSGHE--LHLDGRDGQLLLAILLQMTMSDYPPLTSIAL 3345
+++ E + I+ S L LD G+ L +LL +TM DYPPL S AL
Sbjct: 1006 PSNVPGALDFEHIEEQAEGIFGGSEENTPLDLDDHGGRTFLRVLLHLTMHDYPPLVSGAL 1065
Query: 3346 KVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHS 3525
++ FRHF+Q QE+L+ KQVQLLV++ DV+NY+QI +DL L+++ EKSELWV+ +
Sbjct: 1066 QLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQG-- 1123
Query: 3526 IDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLL 3705
+ +D EH + P +S S
Sbjct: 1124 -PDEPMDGASGENEHKKTEEGTSKPLKHESTSSYN------------------------- 1157
Query: 3706 IKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDP--KPDTMNQQLLKNMR 3879
Y +++++L+RL+ +C ++ K Q+LL+NM
Sbjct: 1158 -----------------------YRVVKEILIRLSKLCVQESASVRKSRKQQQRLLRNMG 1194
Query: 3880 VYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGM 4059
+ VVLE + +P++K D M +++ L+HEFL++FC N++NQ+ L+K I+ +
Sbjct: 1195 AHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHIN--------L 1246
Query: 4060 LRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDK 4239
I E T+ IF NN +L S + E ++ H V IE + RN +++ LQ +V K
Sbjct: 1247 FLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAEGK 1306
Query: 4240 EIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIEL 4419
I+ Q+ V E+ + ++V Y D ASF+ L MM+ E++ R ++ YHI L
Sbjct: 1307 FIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERD---RMDENSPLFMYHIHL 1363
Query: 4420 VRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEM 4599
V LLA+CT GKN TE+KC S +P+D IVRVVT + C+ EVK Y+ L HCY+DT+ EM
Sbjct: 1364 VELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCYVDTEVEM 1423
Query: 4600 KDAYKTEYVDHILNNLLEDI-RSLRVEKLTGAETATLEHYICHTVTEVLIKFFEAPYSAL 4776
K+ Y + ++ + N L DI R+ + LE Y+ V ++ FF +P+S
Sbjct: 1424 KEIYTSNHMWKLFENFLVDICRACNNTSDRKHADSVLEKYVTEIVMSIVTTFFSSPFS-- 1481
Query: 4777 QQAKVDVHHHKKTFSEVLLEL--TYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNIT 4950
+ + F ++L + Y + K+S V CI+ L+ A+ I
Sbjct: 1482 -DQSTTLQTRQPVFVQLLQGVFRVYHCNWLMPSQKAS-----VESCIRVLSDVAKSRAIA 1535
Query: 4951 LPATLAGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHTS 5130
+P L + V + ++ + + + RL+ +N L + +
Sbjct: 1536 IPVDL-------DSQVNNLFLKSHNIVQKTAMNWRLSARNAARRDSVLAASRD------Y 1582
Query: 5131 ANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLI 5310
N++ ++ + L PL AE SVLV+VLH PELLFPE + R +C GG + KLI
Sbjct: 1583 RNIIERLQDIVSALEDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKCESGGFICKLI 1642
Query: 5311 QHCKTLMQNKQDNLCARVLQTLCKM 5385
+H K L++ ++ LC +VLQTL +M
Sbjct: 1643 KHTKQLLEENEEKLCIKVLQTLREM 1667
Score = 615 bits (1585), Expect = e-174
Identities = 378/1021 (37%), Positives = 557/1021 (54%), Gaps = 32/1021 (3%)
Frame = +1
Query: 5560 ERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMK 5739
E L +QC L+ GAS+LV D+I+ S +F ++I LA ALL GN +QHSF+ R+
Sbjct: 1773 EMSLAEVQCHLDKEGASNLVIDLIMNASSDRVFHESILLAIALLEGGNTTIQHSFFCRLT 1832
Query: 5740 QKDIHEPFFKAILTRIQTAQNRLKSDM-MSCSDSKPK-----VSLSATVSRRSSTVLTPL 5901
+ E FFK R++ AQ +K+ + ++ SD K V A +++ T +
Sbjct: 1833 EDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPTTQI 1892
Query: 5902 IDAGDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQ---------DEEKST 6054
+ EV Q+ S + + + PD YQ D+ K
Sbjct: 1893 TE-----------EVRDQLLEASAATRKAFTTFRREADPD-DHYQSGEGTQATTDKAKDD 1940
Query: 6055 DALPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKG 6234
+ + +++PILR LQLLCENHN LQNFLR Q+++TN+NLV ETL FLD +CGST G
Sbjct: 1941 LEMSAVITIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDCICGSTTG 2000
Query: 6235 SLGVFG-EIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQE-NGLNIIISLVLNEIKP 6408
LG+ G I E N +LI QTL +LTE+CQGPCHENQN +A E NG++II +L+LN
Sbjct: 2001 GLGLLGLYINEKNVALINQTLESLTEYCQGPCHENQNCIATHESNGIDIITALILN---- 2056
Query: 6409 LADDHMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEM 6588
+I K + ++E L+N A+ K L+ ++ ++
Sbjct: 2057 ----------DINPLGKKRMDLVLE-----------LKNNAS-----KLLLAIMESRHDS 2090
Query: 6589 TNSNHHMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSS 6768
N+ + ++L ++ KK+ Q V
Sbjct: 2091 ENAERILYNMRPKELV-----EVIKKAYMQGEVE-------------------------- 2119
Query: 6769 LDDKFNDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKE 6948
+D N +D + PR VGHNIYILAHQLA H+ EL+ L + D EAL +Y +
Sbjct: 2120 FEDGENGED-GAASPRNVGHNIYILAHQLARHNKELQTMLKPGGQVDGD---EALEFYAK 2175
Query: 6949 RTAQIEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMY 7128
TAQIEIVR DRT+E++VFP+ IC +LTK++K +Y TERD QGSK+ +FF E ++
Sbjct: 2176 HTAQIEIVRLDRTMEQIVFPVPSICEFLTKESKLRIYYTTERDEQGSKINDFFLRSEDLF 2235
Query: 7129 HEMIWQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSIS---LG 7299
+EM WQ+KL+ + L WCA + W+ +SF+ A ++N LVA +YP ++ G
Sbjct: 2236 NEMNWQKKLRAQPVLYWCARNMSFWSSISFNLAVLMNLLVAFFYPFKGVRGGTLEPHWSG 2295
Query: 7300 NLYSWFAVFSSFLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVN 7479
L++ + + ++A H +G+ TL++ G + N
Sbjct: 2296 LLWTAMLISLAIVIALPKPHG-------IRALIASTILRLIFSVGLQPTLFLLGAFNVCN 2348
Query: 7480 KIVHVVAFVSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTE 7659
KI+ +++FV N G R ++ Y L+YL IC +GL VH Y +LLFD+++ E
Sbjct: 2349 KIIFLMSFVGNCGTFTRGYRAMVLDVEFLYHLLYLLICAMGLFVHEFFYSLLLFDLVYRE 2408
Query: 7660 ETLQNVIASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSS----- 7824
ETL NVI SVTRN + I+ T LALIL+Y FSI+G+L+F+ DF LEVD + N+++
Sbjct: 2409 ETLLNVIKSVTRNGRPIILTAALALILVYLFSIVGYLFFKDDFILEVDRLPNETAGPETG 2468
Query: 7825 -ATISSGIPSETC---PSEGCPGLQPSXXXX---XXXXXXXXSCETLWMCILQTGYQGLR 7983
+ + + S+ C E C P +CETL MCI+ GLR
Sbjct: 2469 ESLANDFLYSDVCRVETGENCTSPAPKEELLPVEETEQDKEHTCETLLMCIVTVLSHGLR 2528
Query: 7984 NGGGIGDVLRNPAPWEDMFIWRVAYDMTXXXXXXXXXXXXXXXXXXDTFGDLRAEKNEKE 8163
+GGG+GDVLR P+ E +F RV YD+ DTF DLR+EK +KE
Sbjct: 2529 SGGGVGDVLRKPSKEEPLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKE 2588
Query: 8164 QILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPESYVA 8343
+ILK CFICGL+R +FDN++VTFE H + EHN+WHYL +IV++++KD TE+TGPESYVA
Sbjct: 2589 EILKTTCFICGLERDKFDNKTVTFEEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVA 2648
Query: 8344 QCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLLQMMTLMREIISQNEESRAFME 8523
+ +++RNLDWFPRM+A+SL S+ + +Q+E++ ++++L M L+ + Q E + M
Sbjct: 2649 EMIRERNLDWFPRMRAMSLVSSDSEGEQNELRNLQEKLESTMKLVTNLSGQLSELKDQMT 2708
Query: 8524 Q 8526
+
Sbjct: 2709 E 2709
>gi|6754390|ref|NP_034715.1| inositol 1,4,5-triphosphate receptor 1;
InsP3R type I; Purkinje cell protein 1; opisthotonus;
InsP>3gi|34857738|ref|XP_342733.1| similar to Inositol 1,4,5-trisphosphate
receptor type 1 (Type 1 inositol 1,4,5-trisphosphate
receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform
1) (InsP3R1) (IP-3-R) [Rattus norvegicus]
Length = 2749
Score = 1058 bits (2735), Expect = 0.0
Identities = 678/1824 (37%), Positives = 999/1824 (54%), Gaps = 65/1824 (3%)
Frame = +1
Query: 109 LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
LHIGDI SLY E S+N GF+STLGLVDDRC+V+ + G +PPKKFRDCLFK+CP+N
Sbjct: 9 LHIGDICSLYAEGSTN----GFISTLGLVDDRCVVQPEAGDLNNPPKKFRDCLFKLCPMN 64
Query: 289 RYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQ 468
RY+AQK W K +S D L+NKL AAD E+++NE+E +K LG VIQYG+++Q
Sbjct: 65 RYSAQKQFWKAAK--PGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQ 122
Query: 469 LLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKI 648
LLH+KSNKY+TV K PA E+NAM+V LD AGNEGSWF I+P YK +IGD+V G+K+
Sbjct: 123 LLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGDKV 182
Query: 649 SLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSV 828
L P AG LH SS L+D+ EVN +N T W++ +F+ + +N+ + +
Sbjct: 183 VLNP-----VNAG---QPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDIL 234
Query: 829 KSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTN 1008
K GDVVRLFHA+Q+ FLT D K+ VFLR T R SA ATSS+ALWEV+VVQ +
Sbjct: 235 KGGDVVRLFHAEQEKFLTCDEHRKKQH----VFLRTTGRQSATSATSSKALWEVEVVQHD 290
Query: 1009 AYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRRASLIYSKTNNPMAMYSDGP 1188
RGG WN +RFKHLAT YL+AE V P + L + + +P D
Sbjct: 291 PCRGGAGYWNSLFRFKHLATGHYLAAE-----VDP--DFEEECLEFQPSVDP---DQDAS 340
Query: 1189 NGVTNESTDTTQQNIPSVWVLGPTKSEFPE-EDANLLFQLDPSTFMKSNKEVPRRSYVRL 1365
+ + ++ SV PE D + +F+LDP+T + VPR SYVRL
Sbjct: 341 RSRLRNAQEKMVYSLVSV----------PEGNDISSIFELDPTTLRGGDSLVPRNSYVRL 390
Query: 1366 LHQSSDKWVHATNATEKQNLHYSSKNEKG-WVKVICEKNRVDKETFALLPVNPDEVRDLD 1542
H ++ WVH+T N+ + EK +K+ + DKE FA++PV+P EVRDLD
Sbjct: 391 RHLCTNTWVHST------NIPIDKEEEKPVMLKIGTSPLKEDKEAFAIVPVSPAEVRDLD 444
Query: 1543 FANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPS 1722
FANDA K L + ++ G + E S T+LL D + FVT ++ D L++ P+
Sbjct: 445 FANDASKVLGSIAGKLEKGTITQNER-RSVTKLLEDLVYFVTGGTNSGQDVLEVVFSKPN 503
Query: 1723 RDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIFKTMFQLCYC 1902
R+RQKL+REQ +L Q+F LL+APF T D R+ F+ + +LCY
Sbjct: 504 RERQKLMREQNILKQIFKLLQAPF-----TDCGDGPMLRLEELGDQRHAPFRHICRLCYR 558
Query: 1903 LLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERF 2082
+L++SQ YRKNQE++A++FG +Q+QIG+D++AEDT+TA+LHNN KLLEK++ ++ F
Sbjct: 559 VLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKHITAAEIDTF 618
Query: 2083 VELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKII------- 2241
V LVR NR+ +FLDYL+DLCV ++ QELIC +VL+ + DI ++TK++
Sbjct: 619 VSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETKLVLSRFEFE 678
Query: 2242 --------------DGEIEVGWAPNFRKL-----VDIAEGAK-SNSDDAEHLDYYRHQLD 2361
+ E+ + W + +++ ++A+ AK +D + L YYR+QL+
Sbjct: 679 GVSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDAKEGQKEDRDVLSYYRYQLN 738
Query: 2362 LLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLHLHV 2541
L ++MC ++QYLAI+ IS QL +L+L+CMSD LPYDLR SF RLMLH+HV
Sbjct: 739 LFARMCLDRQYLAIN--------EISGQLDVDLILRCMSDENLPYDLRASFCRLMLHMHV 790
Query: 2542 VRG--SPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATVETY 2715
R ++ +++ARLW IP + + Y+S S S+ I E A + + VE Y
Sbjct: 791 DRDPQEQVTPVKYARLWSEIPSEIAIDDYDS------SGASKDEIKERFA-QTMEFVEEY 843
Query: 2716 LMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINEGPATE 2895
L + Q +KLT+E+VNLA+ L F FY+F+DLL+LT+ LLAI++ T
Sbjct: 844 LRDVVCQRFPFSDK-EKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCVHVTT 902
Query: 2896 QVPSHRAM-------VNAIRN-------MSKSMMRGGNKENSKDLAKTPSVTAEEAGRTK 3033
P + N +R+ M++ ++RGG +A P ++A K
Sbjct: 903 IFPISKMTKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEGNVKQAEPEK 962
Query: 3034 EGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFP-------------CDEDGS 3174
E + + TKL + EILQF+++VR DYRI+ L FK F ++G
Sbjct: 963 ED-IMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQSSETSSGNSSQEGP 1021
Query: 3175 LMHSASINERMASELYDAIYRSSGHE--LHLDGRDGQLLLAILLQMTMSDYPPLTSIALK 3348
+++ E + I+ S L LD G+ L +LL +TM DYPPL S AL+
Sbjct: 1022 SNVPGALDFEHIEEQAEGIFGGSEENTPLDLDDHGGRTFLRVLLHLTMHDYPPLVSGALQ 1081
Query: 3349 VFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSI 3528
+ FRHF+Q QE+L+ KQVQLLV++ DV+NY+QI +DL L+++ EKSELWV+ +
Sbjct: 1082 LLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQG--- 1138
Query: 3529 DTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLI 3708
+ +D EH + P +S S
Sbjct: 1139 PDEPMDGASGENEHKKTEEGTSKPLKHESTSSYN-------------------------- 1172
Query: 3709 KDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDP--KPDTMNQQLLKNMRV 3882
Y +++++L+RL+ +C ++ K Q+LL+NM
Sbjct: 1173 ----------------------YRVVKEILIRLSKLCVQESASVRKSRKQQQRLLRNMGA 1210
Query: 3883 YEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGML 4062
+ VVLE + +P++K D M +++ L+HEFL++FC N++NQ+ L+K I+ +
Sbjct: 1211 HAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHIN--------LF 1262
Query: 4063 RVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKE 4242
I E T+ IF NN +L S + E ++ H V IE + RN +++ LQ +V K
Sbjct: 1263 LNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAEGKF 1322
Query: 4243 IESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELV 4422
I+ Q+ V E+ + ++V Y D ASF+ L MM+ E++ D L YHI LV
Sbjct: 1323 IKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERD----RMDENSPLMYHIHLV 1378
Query: 4423 RLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMK 4602
LLA+CT GKN TE+KC S +P+D IVRVVT + C+ EVK Y+ L HCY+DT+ EMK
Sbjct: 1379 ELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCYVDTEVEMK 1438
Query: 4603 DAYKTEYVDHILNNLLEDI-RSLRVEKLTGAETATLEHYICHTVTEVLIKFFEAPYSALQ 4779
+ Y + ++ + N L DI R+ + LE Y+ V ++ FF +P+S
Sbjct: 1439 EIYTSNHMWKLFENFLVDICRACNNTSDRKHADSVLEKYVTEIVMSIVTTFFSSPFS--- 1495
Query: 4780 QAKVDVHHHKKTFSEVLLEL--TYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNITL 4953
+ + F ++L + Y + K+S V CI+ L+ A+ I +
Sbjct: 1496 DQSTTLQTRQPVFVQLLQGVFRVYHCNWLMPSQKAS-----VESCIRVLSDVAKSRAIAI 1550
Query: 4954 PATLAGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHTSA 5133
P L + V + ++ + + + RL+ +N L + +
Sbjct: 1551 PVDL-------DSQVNNLFLKSHNIVQKTAMNWRLSARNAARRDSVLAASRD------YR 1597
Query: 5134 NVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQ 5313
N++ ++ + L PL AE SVLV+VLH PELLFPE + R +C GG + KLI+
Sbjct: 1598 NIIERLQDIVSALEDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKCESGGFICKLIK 1657
Query: 5314 HCKTLMQNKQDNLCARVLQTLCKM 5385
H K L++ ++ LC +VLQTL +M
Sbjct: 1658 HTKQLLEENEEKLCIKVLQTLREM 1681
Score = 617 bits (1592), Expect = e-174
Identities = 379/1021 (37%), Positives = 559/1021 (54%), Gaps = 32/1021 (3%)
Frame = +1
Query: 5560 ERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMK 5739
E L +QC L+ GAS+LV D+I+ S +F ++I LA ALL GN +QHSF+ R+
Sbjct: 1788 EMSLAEVQCHLDKEGASNLVIDLIMNASSDRVFHESILLAIALLEGGNTTIQHSFFCRLT 1847
Query: 5740 QKDIHEPFFKAILTRIQTAQNRLKSDM-MSCSDSKPK-----VSLSATVSRRSSTVLTPL 5901
+ E FFK R++ AQ +K+ + ++ SD K V A +++ T +
Sbjct: 1848 EDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPTTQI 1907
Query: 5902 IDAGDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQ---------DEEKST 6054
+ EV Q+ S + + + PD YQ D+ K
Sbjct: 1908 TE-----------EVRDQLLEASAATRKAFTTFRREADPD-DHYQSGEGTQATTDKAKDD 1955
Query: 6055 DALPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKG 6234
+ + +++PILR LQLLCENHN LQNFLR Q+++TN+NLV ETL FLD +CGST G
Sbjct: 1956 LEMSAVITIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDCICGSTTG 2015
Query: 6235 SLGVFG-EIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQE-NGLNIIISLVLNEIKP 6408
LG+ G I E N +LI QTL +LTE+CQGPCHENQN +A E NG++II +L+LN
Sbjct: 2016 GLGLLGLYINEKNVALINQTLESLTEYCQGPCHENQNCIATHESNGIDIITALILN---- 2071
Query: 6409 LADDHMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEM 6588
+I K + ++E L+N A+ K L+ ++ ++
Sbjct: 2072 ----------DINPLGKKRMDLVLE-----------LKNNAS-----KLLLAIMESRHDS 2105
Query: 6589 TNSNHHMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSS 6768
N+ + ++L ++ KK+ Q V
Sbjct: 2106 ENAERILYNMRPKELV-----EVIKKAYMQGEVE-------------------------- 2134
Query: 6769 LDDKFNDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKE 6948
+D N +D + PR VGHNIYILAHQLA H+ EL+ L + D EAL +Y +
Sbjct: 2135 FEDGENGED-GAASPRNVGHNIYILAHQLARHNKELQTMLKPGGQVDGD---EALEFYAK 2190
Query: 6949 RTAQIEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMY 7128
TAQIEIVR DRT+E++VFP+ IC +LTK++K +Y TERD QGSK+ +FF E ++
Sbjct: 2191 HTAQIEIVRLDRTMEQIVFPVPSICEFLTKESKLRIYYTTERDEQGSKINDFFLRSEDLF 2250
Query: 7129 HEMIWQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSIS---LG 7299
+EM WQ+KL+ + L WCA + W+ +SF+ A ++N LVA +YP ++ G
Sbjct: 2251 NEMNWQKKLRAQPVLYWCARNMSFWSSISFNLAVLMNLLVAFFYPFKGVRGGTLEPHWSG 2310
Query: 7300 NLYSWFAVFSSFLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVN 7479
L++ + + ++A H +G+ TL++ G + N
Sbjct: 2311 LLWTAMLISLAIVIALPKPHG-------IRALIASTILRLIFSVGLQPTLFLLGAFNVCN 2363
Query: 7480 KIVHVVAFVSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTE 7659
KI+ +++FV N G R ++ Y L+YL IC +GL VH Y +LLFD+++ E
Sbjct: 2364 KIIFLMSFVGNCGTFTRGYRAMVLDVEFLYHLLYLLICAMGLFVHEFFYSLLLFDLVYRE 2423
Query: 7660 ETLQNVIASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSS----- 7824
ETL NVI SVTRN +SI+ T +LALIL+Y FSI+G+L+F+ DF LEVD + N+++
Sbjct: 2424 ETLLNVIKSVTRNGRSIILTAVLALILVYLFSIVGYLFFKDDFILEVDRLPNETAGPETG 2483
Query: 7825 -ATISSGIPSETC---PSEGCPGLQPSXXXX---XXXXXXXXSCETLWMCILQTGYQGLR 7983
+ + + S+ C E C P +CETL MCI+ GLR
Sbjct: 2484 ESLANDFLYSDVCRVETGENCTSPAPKEELLPVEETEQDKEHTCETLLMCIVTVLSHGLR 2543
Query: 7984 NGGGIGDVLRNPAPWEDMFIWRVAYDMTXXXXXXXXXXXXXXXXXXDTFGDLRAEKNEKE 8163
+GGG+GDVLR P+ E +F RV YD+ DTF DLR+EK +KE
Sbjct: 2544 SGGGVGDVLRKPSKEEPLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKE 2603
Query: 8164 QILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPESYVA 8343
+ILK CFICGL+R +FDN++VTFE H + EHN+WHYL +IV++++KD TE+TGPESYVA
Sbjct: 2604 EILKTTCFICGLERDKFDNKTVTFEEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVA 2663
Query: 8344 QCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLLQMMTLMREIISQNEESRAFME 8523
+ +++RNLDWFPRM+A+SL S+ + +Q+E++ ++++L M L+ + Q E + M
Sbjct: 2664 EMIRERNLDWFPRMRAMSLVSSDSEGEQNELRNLQEKLESTMKLVTNLSGQLSELKDQMT 2723
Query: 8524 Q 8526
+
Sbjct: 2724 E 2724
>gi|17380349|sp|P29994|IP3R_RAT Inositol 1,4,5-trisphosphate receptor
type 1 (Type 1 inositol 1,4,5-trisphosphate receptor)
(Type 1 InsP3 receptor) (IP3 receptor isoform 1)
(InsP3R1) (IP-3-R)
Length = 2750
Score = 1056 bits (2732), Expect = 0.0
Identities = 677/1824 (37%), Positives = 1000/1824 (54%), Gaps = 65/1824 (3%)
Frame = +1
Query: 109 LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
LHIGDI SLY E S+N GF+STLGLVDDRC+V+ + G +PPKKFRDCLFK+CP+N
Sbjct: 9 LHIGDICSLYAEGSTN----GFISTLGLVDDRCVVQPEAGDLNNPPKKFRDCLFKLCPMN 64
Query: 289 RYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQ 468
RY+AQK W K +S D L+NKL AAD E+++NE+E +K LG VIQYG+++Q
Sbjct: 65 RYSAQKQFWKAAK--PGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQ 122
Query: 469 LLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKI 648
LLH+KSNKY+TV K PA E+NAM+V LD AGNEGSWF I+P YK +IGD+V G+K+
Sbjct: 123 LLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGDKV 182
Query: 649 SLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSV 828
L P AG LH SS L+D+ EVN +N T W++ +F+ + +N+ + +
Sbjct: 183 VLNP-----VNAG---QPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDIL 234
Query: 829 KSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTN 1008
K GDVVRLFHA+Q+ FLT D K+ VFLR T R SA ATSS+ALWEV+VVQ +
Sbjct: 235 KGGDVVRLFHAEQEKFLTCDEHRKKQH----VFLRTTGRQSATSATSSKALWEVEVVQHD 290
Query: 1009 AYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRRASLIYSKTNNPMAMYSDGP 1188
RGG WN +RFKHLAT YL+AE V P + L + + +P D
Sbjct: 291 PCRGGAGYWNSLFRFKHLATGHYLAAE-----VDP--DFEEECLEFQPSVDP---DQDAS 340
Query: 1189 NGVTNESTDTTQQNIPSVWVLGPTKSEFPE-EDANLLFQLDPSTFMKSNKEVPRRSYVRL 1365
+ + ++ SV PE D + +F+LDP+T + VPR SYVRL
Sbjct: 341 RSRLRNAQEKMVYSLVSV----------PEGNDISSIFELDPTTLRGGDSLVPRNSYVRL 390
Query: 1366 LHQSSDKWVHATNATEKQNLHYSSKNEKG-WVKVICEKNRVDKETFALLPVNPDEVRDLD 1542
H ++ WVH+T N+ + EK +K+ + DKE FA++PV+P EVRDLD
Sbjct: 391 RHLCTNTWVHST------NIPIDKEEEKPVMLKIGTSPLKEDKEAFAIVPVSPAEVRDLD 444
Query: 1543 FANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPS 1722
FANDA K L + ++ G + E S T+LL D + FVT ++ D L++ P+
Sbjct: 445 FANDASKVLGSIAGKLEKGTITQNER-RSVTKLLEDLVYFVTGGTNSGQDVLEVVFSKPN 503
Query: 1723 RDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIFKTMFQLCYC 1902
R+RQKL+REQ +L Q+F LL+APF T D R+ F+ + +LCY
Sbjct: 504 RERQKLMREQNILKQIFKLLQAPF-----TDCGDGPMLRLEELGDQRHAPFRHICRLCYR 558
Query: 1903 LLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERF 2082
+L++SQ YRKNQE++A++FG +Q+QIG+D++AEDT+TA+LHNN KLLEK++ ++ F
Sbjct: 559 VLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKHITAAEIDTF 618
Query: 2083 VELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKII------- 2241
V LVR NR+ +FLDYL+DLCV ++ QELIC +VL+ + DI ++TK++
Sbjct: 619 VSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETKLVLSRFEFE 678
Query: 2242 --------------DGEIEVGWAPNFRKL-----VDIAEGAK-SNSDDAEHLDYYRHQLD 2361
+ E+ + W + +++ ++A+ AK +D + L YYR+QL+
Sbjct: 679 GVSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDAKEGQKEDRDVLSYYRYQLN 738
Query: 2362 LLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLHLHV 2541
L ++MC ++QYLAI+ IS QL +L+L+CMSD LPYDLR SF RLMLH+HV
Sbjct: 739 LFARMCLDRQYLAIN--------EISGQLDVDLILRCMSDENLPYDLRASFCRLMLHMHV 790
Query: 2542 VRG--SPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATVETY 2715
R ++ +++ARLW IP + + Y+S S S+ I E A + + VE Y
Sbjct: 791 DRDPQEQVTPVKYARLWSEIPSEIAIDDYDS------SGASKDEIKERFA-QTMEFVEEY 843
Query: 2716 LMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINEGPATE 2895
L + Q +KLT+E+VNLA+ L F FY+F+DLL+LT+ LLAI++ T
Sbjct: 844 LRDVVCQRFPFSDK-EKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCVHVTT 902
Query: 2896 QVPSHRAM-------VNAIRN-------MSKSMMRGGNKENSKDLAKTPSVTAEEAGRTK 3033
P + N +R+ M++ ++RGG +A P ++A K
Sbjct: 903 IFPISKMTKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEGNVKQAEPEK 962
Query: 3034 EGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFP-------------CDEDGS 3174
E + + TKL + EILQF+++VR DYRI+ L FK F ++G
Sbjct: 963 ED-IMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQSSETSSGNSSQEGP 1021
Query: 3175 LMHSASINERMASELYDAIYRSSGHE--LHLDGRDGQLLLAILLQMTMSDYPPLTSIALK 3348
+++ E + I+ S L LD G+ L +LL +TM DYPPL S AL+
Sbjct: 1022 SNVPGALDFEHIEEQAEGIFGGSEENTPLDLDDHGGRTFLRVLLHLTMHDYPPLVSGALQ 1081
Query: 3349 VFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSI 3528
+ FRHF+Q QE+L+ KQVQLLV++ DV+NY+QI +DL L+++ EKSELWV+ +
Sbjct: 1082 LLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQG--- 1138
Query: 3529 DTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLI 3708
+ +D EH + P +S S
Sbjct: 1139 PDEPMDGASGENEHKKTEEGTSKPLKHESTSSYN-------------------------- 1172
Query: 3709 KDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDP--KPDTMNQQLLKNMRV 3882
Y +++++L+RL+ +C ++ K Q+LL+NM
Sbjct: 1173 ----------------------YRVVKEILIRLSKLCVQESASVRKSRKQQQRLLRNMGA 1210
Query: 3883 YEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGML 4062
+ VVLE + +P++K D M +++ L+HEFL++FC N++NQ+ L+K I+ +
Sbjct: 1211 HAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHIN--------LF 1262
Query: 4063 RVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKE 4242
I E T+ IF NN +L S + E ++ H V IE + RN +++ LQ +V K
Sbjct: 1263 LNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAEGKF 1322
Query: 4243 IESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELV 4422
I+ Q+ V E+ + ++V Y D ASF+ L MM+ E++ R ++ YHI LV
Sbjct: 1323 IKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERD---RMDENSPLFMYHIHLV 1379
Query: 4423 RLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMK 4602
LLA+CT GKN TE+KC S +P+D IVRVVT + C+ EVK Y+ L HCY+DT+ EMK
Sbjct: 1380 ELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCYVDTEVEMK 1439
Query: 4603 DAYKTEYVDHILNNLLEDI-RSLRVEKLTGAETATLEHYICHTVTEVLIKFFEAPYSALQ 4779
+ Y + ++ + N L DI R+ + LE Y+ V ++ FF +P+S
Sbjct: 1440 EIYTSNHMWKLFENFLVDICRACNNTSDRKHADSVLEKYVTEIVMSIVTTFFSSPFS--- 1496
Query: 4780 QAKVDVHHHKKTFSEVLLEL--TYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNITL 4953
+ + F ++L + Y + K+S V CI+ L+ A+ I +
Sbjct: 1497 DQSTTLQTRQPVFVQLLQGVFRVYHCNWLMPSQKAS-----VESCIRVLSDVAKSRAIAI 1551
Query: 4954 PATLAGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHTSA 5133
P L + V + ++ + + + RL+ +N L + +
Sbjct: 1552 PVDL-------DSQVNNLFLKSHNIVQKTAMNWRLSARNAARRDSVLAASRD------YR 1598
Query: 5134 NVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQ 5313
N++ ++ + L PL AE SVLV+VLH PELLFPE + R +C GG + KLI+
Sbjct: 1599 NIIERLQDIVSALEDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKCESGGFICKLIK 1658
Query: 5314 HCKTLMQNKQDNLCARVLQTLCKM 5385
H K L++ ++ LC +VLQTL +M
Sbjct: 1659 HTKQLLEENEEKLCIKVLQTLREM 1682
Score = 615 bits (1585), Expect = e-174
Identities = 378/1021 (37%), Positives = 557/1021 (54%), Gaps = 32/1021 (3%)
Frame = +1
Query: 5560 ERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMK 5739
E L +QC L+ GAS+LV D+I+ S +F ++I LA ALL GN +QHSF+ R+
Sbjct: 1789 EMSLAEVQCHLDKEGASNLVIDLIMNASSDRVFHESILLAIALLEGGNTTIQHSFFCRLT 1848
Query: 5740 QKDIHEPFFKAILTRIQTAQNRLKSDM-MSCSDSKPK-----VSLSATVSRRSSTVLTPL 5901
+ E FFK R++ AQ +K+ + ++ SD K V A +++ T +
Sbjct: 1849 EDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPTTQI 1908
Query: 5902 IDAGDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQ---------DEEKST 6054
+ EV Q+ S + + + PD YQ D+ K
Sbjct: 1909 TE-----------EVRDQLLEASAATRKAFTTFRREADPD-DHYQSGEGTQATTDKAKDD 1956
Query: 6055 DALPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKG 6234
+ + +++PILR LQLLCENHN LQNFLR Q+++TN+NLV ETL FLD +CGST G
Sbjct: 1957 LEMSAVITIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDCICGSTTG 2016
Query: 6235 SLGVFG-EIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQE-NGLNIIISLVLNEIKP 6408
LG+ G I E N +LI QTL +LTE+CQGPCHENQN +A E NG++II +L+LN
Sbjct: 2017 GLGLLGLYINEKNVALINQTLESLTEYCQGPCHENQNCIATHESNGIDIITALILN---- 2072
Query: 6409 LADDHMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEM 6588
+I K + ++E L+N A+ K L+ ++ ++
Sbjct: 2073 ----------DINPLGKKRMDLVLE-----------LKNNAS-----KLLLAIMESRHDS 2106
Query: 6589 TNSNHHMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSS 6768
N+ + ++L ++ KK+ Q V
Sbjct: 2107 ENAERILYNMRPKELV-----EVIKKAYMQGEVE-------------------------- 2135
Query: 6769 LDDKFNDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKE 6948
+D N +D + PR VGHNIYILAHQLA H+ EL+ L + D EAL +Y +
Sbjct: 2136 FEDGENGED-GAASPRNVGHNIYILAHQLARHNKELQTMLKPGGQVDGD---EALEFYAK 2191
Query: 6949 RTAQIEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMY 7128
TAQIEIVR DRT+E++VFP+ IC +LTK++K +Y TERD QGSK+ +FF E ++
Sbjct: 2192 HTAQIEIVRLDRTMEQIVFPVPSICEFLTKESKLRIYYTTERDEQGSKINDFFLRSEDLF 2251
Query: 7129 HEMIWQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSIS---LG 7299
+EM WQ+KL+ + L WCA + W+ +SF+ A ++N LVA +YP ++ G
Sbjct: 2252 NEMNWQKKLRAQPVLYWCARNMSFWSSISFNLAVLMNLLVAFFYPFKGVRGGTLEPHWSG 2311
Query: 7300 NLYSWFAVFSSFLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVN 7479
L++ + + ++A H +G+ TL++ G + N
Sbjct: 2312 LLWTAMLISLAIVIALPKPHG-------IRALIASTILRLIFSVGLQPTLFLLGAFNVCN 2364
Query: 7480 KIVHVVAFVSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTE 7659
KI+ +++FV N G R ++ Y L+YL IC +GL VH Y +LLFD+++ E
Sbjct: 2365 KIIFLMSFVGNCGTFTRGYRAMVLDVEFLYHLLYLLICAMGLFVHEFFYSLLLFDLVYRE 2424
Query: 7660 ETLQNVIASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSS----- 7824
ETL NVI SVTRN + I+ T LALIL+Y FSI+G+L+F+ DF LEVD + N+++
Sbjct: 2425 ETLLNVIKSVTRNGRPIILTAALALILVYLFSIVGYLFFKDDFILEVDRLPNETAGPETG 2484
Query: 7825 -ATISSGIPSETC---PSEGCPGLQPSXXXX---XXXXXXXXSCETLWMCILQTGYQGLR 7983
+ + + S+ C E C P +CETL MCI+ GLR
Sbjct: 2485 ESLANDFLYSDVCRVETGENCTSPAPKEELLPVEETEQDKEHTCETLLMCIVTVLSHGLR 2544
Query: 7984 NGGGIGDVLRNPAPWEDMFIWRVAYDMTXXXXXXXXXXXXXXXXXXDTFGDLRAEKNEKE 8163
+GGG+GDVLR P+ E +F RV YD+ DTF DLR+EK +KE
Sbjct: 2545 SGGGVGDVLRKPSKEEPLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKE 2604
Query: 8164 QILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPESYVA 8343
+ILK CFICGL+R +FDN++VTFE H + EHN+WHYL +IV++++KD TE+TGPESYVA
Sbjct: 2605 EILKTTCFICGLERDKFDNKTVTFEEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVA 2664
Query: 8344 QCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLLQMMTLMREIISQNEESRAFME 8523
+ +++RNLDWFPRM+A+SL S+ + +Q+E++ ++++L M L+ + Q E + M
Sbjct: 2665 EMIRERNLDWFPRMRAMSLVSSDSEGEQNELRNLQEKLESTMKLVTNLSGQLSELKDQMT 2724
Query: 8524 Q 8526
+
Sbjct: 2725 E 2725
>gi|111838|pir||A36579 inositol 1,4,5-triphosphate receptor 1 - rat
gi|204675|gb|AAA41358.1| inositol-1,4,5-triphosphate receptor (alt.,
clone pI16)
Length = 2749
Score = 1056 bits (2732), Expect = 0.0
Identities = 677/1824 (37%), Positives = 1000/1824 (54%), Gaps = 65/1824 (3%)
Frame = +1
Query: 109 LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
LHIGDI SLY E S+N GF+STLGLVDDRC+V+ + G +PPKKFRDCLFK+CP+N
Sbjct: 9 LHIGDICSLYAEGSTN----GFISTLGLVDDRCVVQPEAGDLNNPPKKFRDCLFKLCPMN 64
Query: 289 RYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQ 468
RY+AQK W K +S D L+NKL AAD E+++NE+E +K LG VIQYG+++Q
Sbjct: 65 RYSAQKQFWKAAK--PGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQ 122
Query: 469 LLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKI 648
LLH+KSNKY+TV K PA E+NAM+V LD AGNEGSWF I+P YK +IGD+V G+K+
Sbjct: 123 LLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGDKV 182
Query: 649 SLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSV 828
L P AG LH SS L+D+ EVN +N T W++ +F+ + +N+ + +
Sbjct: 183 VLNP-----VNAG---QPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDIL 234
Query: 829 KSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTN 1008
K GDVVRLFHA+Q+ FLT D K+ VFLR T R SA ATSS+ALWEV+VVQ +
Sbjct: 235 KGGDVVRLFHAEQEKFLTCDEHRKKQH----VFLRTTGRQSATSATSSKALWEVEVVQHD 290
Query: 1009 AYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRRASLIYSKTNNPMAMYSDGP 1188
RGG WN +RFKHLAT YL+AE V P + L + + +P D
Sbjct: 291 PCRGGAGYWNSLFRFKHLATGHYLAAE-----VDP--DFEEECLEFQPSVDP---DQDAS 340
Query: 1189 NGVTNESTDTTQQNIPSVWVLGPTKSEFPE-EDANLLFQLDPSTFMKSNKEVPRRSYVRL 1365
+ + ++ SV PE D + +F+LDP+T + VPR SYVRL
Sbjct: 341 RSRLRNAQEKMVYSLVSV----------PEGNDISSIFELDPTTLRGGDSLVPRNSYVRL 390
Query: 1366 LHQSSDKWVHATNATEKQNLHYSSKNEKG-WVKVICEKNRVDKETFALLPVNPDEVRDLD 1542
H ++ WVH+T N+ + EK +K+ + DKE FA++PV+P EVRDLD
Sbjct: 391 RHLCTNTWVHST------NIPIDKEEEKPVMLKIGTSPLKEDKEAFAIVPVSPAEVRDLD 444
Query: 1543 FANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPS 1722
FANDA K L + ++ G + E S T+LL D + FVT ++ D L++ P+
Sbjct: 445 FANDASKVLGSIAGKLEKGTITQNER-RSVTKLLEDLVYFVTGGTNSGQDVLEVVFSKPN 503
Query: 1723 RDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIFKTMFQLCYC 1902
R+RQKL+REQ +L Q+F LL+APF T D R+ F+ + +LCY
Sbjct: 504 RERQKLMREQNILKQIFKLLQAPF-----TDCGDGPMLRLEELGDQRHAPFRHICRLCYR 558
Query: 1903 LLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERF 2082
+L++SQ YRKNQE++A++FG +Q+QIG+D++AEDT+TA+LHNN KLLEK++ ++ F
Sbjct: 559 VLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKHITAAEIDTF 618
Query: 2083 VELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKII------- 2241
V LVR NR+ +FLDYL+DLCV ++ QELIC +VL+ + DI ++TK++
Sbjct: 619 VSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETKLVLSRFEFE 678
Query: 2242 --------------DGEIEVGWAPNFRKL-----VDIAEGAK-SNSDDAEHLDYYRHQLD 2361
+ E+ + W + +++ ++A+ AK +D + L YYR+QL+
Sbjct: 679 GVSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDAKEGQKEDRDVLSYYRYQLN 738
Query: 2362 LLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLHLHV 2541
L ++MC ++QYLAI+ IS QL +L+L+CMSD LPYDLR SF RLMLH+HV
Sbjct: 739 LFARMCLDRQYLAIN--------EISGQLDVDLILRCMSDENLPYDLRASFCRLMLHMHV 790
Query: 2542 VRG--SPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATVETY 2715
R ++ +++ARLW IP + + Y+S S S+ I E A + + VE Y
Sbjct: 791 DRDPQEQVTPVKYARLWSEIPSEIAIDDYDS------SGASKDEIKERFA-QTMEFVEEY 843
Query: 2716 LMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINEGPATE 2895
L + Q +KLT+E+VNLA+ L F FY+F+DLL+LT+ LLAI++ T
Sbjct: 844 LRDVVCQRFPFSDK-EKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCVHVTT 902
Query: 2896 QVPSHRAM-------VNAIRN-------MSKSMMRGGNKENSKDLAKTPSVTAEEAGRTK 3033
P + N +R+ M++ ++RGG +A P ++A K
Sbjct: 903 IFPISKMTKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEGNVKQAEPEK 962
Query: 3034 EGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFP-------------CDEDGS 3174
E + + TKL + EILQF+++VR DYRI+ L FK F ++G
Sbjct: 963 ED-IMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQSSETSSGNSSQEGP 1021
Query: 3175 LMHSASINERMASELYDAIYRSSGHE--LHLDGRDGQLLLAILLQMTMSDYPPLTSIALK 3348
+++ E + I+ S L LD G+ L +LL +TM DYPPL S AL+
Sbjct: 1022 SNVPGALDFEHIEEQAEGIFGGSEENTPLDLDDHGGRTFLRVLLHLTMHDYPPLVSGALQ 1081
Query: 3349 VFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSI 3528
+ FRHF+Q QE+L+ KQVQLLV++ DV+NY+QI +DL L+++ EKSELWV+ +
Sbjct: 1082 LLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQG--- 1138
Query: 3529 DTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLI 3708
+ +D EH + P +S S
Sbjct: 1139 PDEPMDGASGENEHKKTEEGTSKPLKHESTSSYN-------------------------- 1172
Query: 3709 KDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDP--KPDTMNQQLLKNMRV 3882
Y +++++L+RL+ +C ++ K Q+LL+NM
Sbjct: 1173 ----------------------YRVVKEILIRLSKLCVQESASVRKSRKQQQRLLRNMGA 1210
Query: 3883 YEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGML 4062
+ VVLE + +P++K D M +++ L+HEFL++FC N++NQ+ L+K I+ +
Sbjct: 1211 HAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHIN--------LF 1262
Query: 4063 RVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKE 4242
I E T+ IF NN +L S + E ++ H V IE + RN +++ LQ +V K
Sbjct: 1263 LNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAEGKF 1322
Query: 4243 IESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELV 4422
I+ Q+ V E+ + ++V Y D ASF+ L MM+ E++ R ++ YHI LV
Sbjct: 1323 IKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERD---RMDENSPLFMYHIHLV 1379
Query: 4423 RLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMK 4602
LLA+CT GKN TE+KC S +P+D IVRVVT + C+ EVK Y+ L HCY+DT+ EMK
Sbjct: 1380 ELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCYVDTEVEMK 1439
Query: 4603 DAYKTEYVDHILNNLLEDI-RSLRVEKLTGAETATLEHYICHTVTEVLIKFFEAPYSALQ 4779
+ Y + ++ + N L DI R+ + LE Y+ V ++ FF +P+S
Sbjct: 1440 EIYTSNHMWKLFENFLVDICRACNNTSDRKHADSVLEKYVTEIVMSIVTTFFSSPFS--- 1496
Query: 4780 QAKVDVHHHKKTFSEVLLEL--TYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNITL 4953
+ + F ++L + Y + K+S V CI+ L+ A+ I +
Sbjct: 1497 DQSTTLQTRQPVFVQLLQGVFRVYHCNWLMPSQKAS-----VESCIRVLSDVAKSRAIAI 1551
Query: 4954 PATLAGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHTSA 5133
P L + V + ++ + + + RL+ +N L + +
Sbjct: 1552 PVDL-------DSQVNNLFLKSHNIVQKTAMNWRLSARNAARRDSVLAASRD------YR 1598
Query: 5134 NVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQ 5313
N++ ++ + L PL AE SVLV+VLH PELLFPE + R +C GG + KLI+
Sbjct: 1599 NIIERLQDIVSALEDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKCESGGFICKLIK 1658
Query: 5314 HCKTLMQNKQDNLCARVLQTLCKM 5385
H K L++ ++ LC +VLQTL +M
Sbjct: 1659 HTKQLLEENEEKLCIKVLQTLREM 1682
Score = 615 bits (1585), Expect = e-174
Identities = 378/1021 (37%), Positives = 557/1021 (54%), Gaps = 32/1021 (3%)
Frame = +1
Query: 5560 ERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMK 5739
E L +QC L+ GAS+LV D+I+ S +F ++I LA ALL GN +QHSF+ R+
Sbjct: 1788 EMSLAEVQCHLDKEGASNLVIDLIMNASSDRVFHESILLAIALLEGGNTTIQHSFFCRLT 1847
Query: 5740 QKDIHEPFFKAILTRIQTAQNRLKSDM-MSCSDSKPK-----VSLSATVSRRSSTVLTPL 5901
+ E FFK R++ AQ +K+ + ++ SD K V A +++ T +
Sbjct: 1848 EDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPTTQI 1907
Query: 5902 IDAGDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQ---------DEEKST 6054
+ EV Q+ S + + + PD YQ D+ K
Sbjct: 1908 TE-----------EVRDQLLEASAATRKAFTTFRREADPD-DHYQSGEGTQATTDKAKDD 1955
Query: 6055 DALPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKG 6234
+ + +++PILR LQLLCENHN LQNFLR Q+++TN+NLV ETL FLD +CGST G
Sbjct: 1956 LEMSAVITIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDCICGSTTG 2015
Query: 6235 SLGVFG-EIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQE-NGLNIIISLVLNEIKP 6408
LG+ G I E N +LI QTL +LTE+CQGPCHENQN +A E NG++II +L+LN
Sbjct: 2016 GLGLLGLYINEKNVALINQTLESLTEYCQGPCHENQNCIATHESNGIDIITALILN---- 2071
Query: 6409 LADDHMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEM 6588
+I K + ++E L+N A+ K L+ ++ ++
Sbjct: 2072 ----------DINPLGKKRMDLVLE-----------LKNNAS-----KLLLAIMESRHDS 2105
Query: 6589 TNSNHHMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSS 6768
N+ + ++L ++ KK+ Q V
Sbjct: 2106 ENAERILYNMRPKELV-----EVIKKAYMQGEVE-------------------------- 2134
Query: 6769 LDDKFNDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKE 6948
+D N +D + PR VGHNIYILAHQLA H+ EL+ L + D EAL +Y +
Sbjct: 2135 FEDGENGED-GAASPRNVGHNIYILAHQLARHNKELQTMLKPGGQVDGD---EALEFYAK 2190
Query: 6949 RTAQIEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMY 7128
TAQIEIVR DRT+E++VFP+ IC +LTK++K +Y TERD QGSK+ +FF E ++
Sbjct: 2191 HTAQIEIVRLDRTMEQIVFPVPSICEFLTKESKLRIYYTTERDEQGSKINDFFLRSEDLF 2250
Query: 7129 HEMIWQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSIS---LG 7299
+EM WQ+KL+ + L WCA + W+ +SF+ A ++N LVA +YP ++ G
Sbjct: 2251 NEMNWQKKLRAQPVLYWCARNMSFWSSISFNLAVLMNLLVAFFYPFKGVRGGTLEPHWSG 2310
Query: 7300 NLYSWFAVFSSFLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVN 7479
L++ + + ++A H +G+ TL++ G + N
Sbjct: 2311 LLWTAMLISLAIVIALPKPHG-------IRALIASTILRLIFSVGLQPTLFLLGAFNVCN 2363
Query: 7480 KIVHVVAFVSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTE 7659
KI+ +++FV N G R ++ Y L+YL IC +GL VH Y +LLFD+++ E
Sbjct: 2364 KIIFLMSFVGNCGTFTRGYRAMVLDVEFLYHLLYLLICAMGLFVHEFFYSLLLFDLVYRE 2423
Query: 7660 ETLQNVIASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSS----- 7824
ETL NVI SVTRN + I+ T LALIL+Y FSI+G+L+F+ DF LEVD + N+++
Sbjct: 2424 ETLLNVIKSVTRNGRPIILTAALALILVYLFSIVGYLFFKDDFILEVDRLPNETAGPETG 2483
Query: 7825 -ATISSGIPSETC---PSEGCPGLQPSXXXX---XXXXXXXXSCETLWMCILQTGYQGLR 7983
+ + + S+ C E C P +CETL MCI+ GLR
Sbjct: 2484 ESLANDFLYSDVCRVETGENCTSPAPKEELLPVEETEQDKEHTCETLLMCIVTVLSHGLR 2543
Query: 7984 NGGGIGDVLRNPAPWEDMFIWRVAYDMTXXXXXXXXXXXXXXXXXXDTFGDLRAEKNEKE 8163
+GGG+GDVLR P+ E +F RV YD+ DTF DLR+EK +KE
Sbjct: 2544 SGGGVGDVLRKPSKEEPLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKE 2603
Query: 8164 QILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPESYVA 8343
+ILK CFICGL+R +FDN++VTFE H + EHN+WHYL +IV++++KD TE+TGPESYVA
Sbjct: 2604 EILKTTCFICGLERDKFDNKTVTFEEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVA 2663
Query: 8344 QCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLLQMMTLMREIISQNEESRAFME 8523
+ +++RNLDWFPRM+A+SL S+ + +Q+E++ ++++L M L+ + Q E + M
Sbjct: 2664 EMIRERNLDWFPRMRAMSLVSSDSEGEQNELRNLQEKLESTMKLVTNLSGQLSELKDQMT 2723
Query: 8524 Q 8526
+
Sbjct: 2724 E 2724
>gi|17366467|sp|Q14643|IP3R_HUMAN Inositol 1,4,5-trisphosphate
receptor type 1 (Type 1 inositol 1,4,5-trisphosphate
receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform
1) (InsP3R1) (IP3R)
Length = 2758
Score = 1055 bits (2729), Expect = 0.0
Identities = 679/1834 (37%), Positives = 1000/1834 (54%), Gaps = 75/1834 (4%)
Frame = +1
Query: 109 LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
LHIGDI SLY E S+N GF+STLGLVDDRC+V+ + G +PPKKFRDCLFK+CP+N
Sbjct: 9 LHIGDICSLYAEGSTN----GFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKLCPMN 64
Query: 289 RYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQ 468
RY+AQK W K +S D L+NKL AAD E+++NE+E +K LG VIQYG+++Q
Sbjct: 65 RYSAQKQFWKAAK--PGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQ 122
Query: 469 LLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKI 648
LLH+KSNKY+TV K PA E+NAM+V LD AGNEGSWF I+P YK +IGD+V G+K+
Sbjct: 123 LLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGDKV 182
Query: 649 SLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSV 828
L P AG LH SS L+D+ EVN +N T W++ +F+ + +N+ + +
Sbjct: 183 VLNP-----VNAG---QPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDIL 234
Query: 829 KSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTN 1008
K GDVVRLFHA+Q+ FLT D K+ VFLR T R SA ATSS+ALWEV+VVQ +
Sbjct: 235 KGGDVVRLFHAEQEKFLTCDEHRKKQH----VFLRTTGRQSATSATSSKALWEVEVVQHD 290
Query: 1009 AYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRRASLIYSKTNNPMAMYSDGP 1188
RGG WN +RFKHLAT YL+AE V P + L + + +P D
Sbjct: 291 PCRGGAGYWNSLFRFKHLATGHYLAAE-----VDP--DFEEECLEFQPSVDP---DQDAS 340
Query: 1189 NGVTNESTDTTQQNIPSVWVLGPTKSEFPE-EDANLLFQLDPSTFMKSNKEVPRRSYVRL 1365
+ + ++ SV PE D + +F+LDP+T + VPR SYVRL
Sbjct: 341 RSRLRNAQEKMVYSLVSV----------PEGNDISSIFELDPTTLRGGDSLVPRNSYVRL 390
Query: 1366 LHQSSDKWVHATNATEKQNLHYSSKNEKG-WVKVICEKNRVDKETFALLPVNPDEVRDLD 1542
H ++ WVH+T N+ + EK +K+ + DKE FA++PV+P EVRDLD
Sbjct: 391 RHLCTNTWVHST------NIPIDKEEEKPVMLKIGTSPVKEDKEAFAIVPVSPAEVRDLD 444
Query: 1543 FANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPS 1722
FANDA K L + ++ G + E S T+LL D + FVT ++ D L++ P+
Sbjct: 445 FANDASKVLGSIAGKLEKGTITQNER-RSVTKLLEDLVYFVTGGTNSGQDVLEVVFSKPN 503
Query: 1723 RDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIFKTMFQLCYC 1902
R+RQKL+REQ +L Q+F LL+APF T D R+ F+ + +LCY
Sbjct: 504 RERQKLMREQNILKQIFKLLQAPF-----TDCGDGPMLRLEELGDQRHAPFRHICRLCYR 558
Query: 1903 LLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERF 2082
+L++SQ YRKNQE++A++FG +Q+QIG+D++AEDT+TA+LHNN KLLEK++ ++ F
Sbjct: 559 VLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKHITAAEIDTF 618
Query: 2083 VELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKII------- 2241
V LVR NR+ +FLDYL+DLCV ++ QELIC +VL+ + DI ++TK++
Sbjct: 619 VSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETKLVLSRFEFE 678
Query: 2242 ---------------DGEIEVGWAPNFRKL-----VDIAEGAK-SNSDDAEHLDYYRHQL 2358
+ E+ + W + +++ ++A+ AK +D + L YYR+QL
Sbjct: 679 GVSSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDAKEGQKEDRDVLSYYRYQL 738
Query: 2359 DLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLHLH 2538
+L ++MC ++QYLAI+ IS QL +L+L+CMSD LPYDLR SF RLMLH+H
Sbjct: 739 NLFARMCLDRQYLAIN--------EISGQLDVDLILRCMSDENLPYDLRASFCRLMLHMH 790
Query: 2539 VVRG--SPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATVET 2712
V R ++ +++ARLW IP + + Y+S S S+ I E A + + VE
Sbjct: 791 VDRDPQEQVTPVKYARLWSEIPSEIAIDDYDS------SGASKDEIKERFA-QTMEFVEE 843
Query: 2713 YLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINEGPAT 2892
YL + Q +KLT+E+VNLA+ L F FY+F+DLL+LT+ LLAI++ T
Sbjct: 844 YLRDVVCQRFPFSDK-EKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCVHVT 902
Query: 2893 EQVPSHR----------------AMVNAIRN-------MSKSMMRGGNKENSKDLAKTPS 3003
P + N +R+ M++ ++RGG +A P
Sbjct: 903 TIFPISKMAKGEENKGNNDVEKLKSSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPE 962
Query: 3004 VTAEEAGRTKEGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFP--------- 3156
++A KE + + TKL + EILQF+++VR DYRI+ L FK F
Sbjct: 963 GNVKQAEPEKED-IMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQTSET 1021
Query: 3157 ----CDEDGSLMHSASINERMASELYDAIYRSSGHE--LHLDGRDGQLLLAILLQMTMSD 3318
++G +++ E + I+ S L LD G+ L +LL +TM D
Sbjct: 1022 SSGNSSQEGPSNVPGALDFEHIEEQAEGIFGGSEENTPLDLDDHGGRTFLRVLLHLTMHD 1081
Query: 3319 YPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSEL 3498
YPPL S AL++ FRHF+Q QE+L+ KQVQLLV++ DV+NY+QI +DL L+++ EKSEL
Sbjct: 1082 YPPLVSGALQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSEL 1141
Query: 3499 WVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNE 3678
WV+ + + +D EH + P+ +S S
Sbjct: 1142 WVYKGQG---PDETMDGASGENEHKKTEEGNNKPQKHESTSSYN---------------- 1182
Query: 3679 CLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDP--KPDTM 3852
Y +++++L+RL+ +C ++ K
Sbjct: 1183 --------------------------------YRVVKEILIRLSKLCVQESASVRKSRKQ 1210
Query: 3853 NQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFIS 4032
Q+LL+NM + VVLE + +P++K D M +++ L+HEFL++FC N++NQ+ L+K I+
Sbjct: 1211 QQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHIN 1270
Query: 4033 YEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLELL 4212
+ I E T+ IF NN +L S + E ++ H V IE + RN +++ L
Sbjct: 1271 --------LFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFL 1322
Query: 4213 QALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSDSR 4392
Q +V K I+ Q+ V E+ + ++V Y D ASF+ L MM+ E++ D
Sbjct: 1323 QTIVKAEGKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERD----RMDEN 1378
Query: 4393 RKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLH 4572
L YHI LV LLA+CT GKN TE+KC S +P+D IVRVVT + C+ EVK Y+ L H
Sbjct: 1379 SPLMYHIHLVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNH 1438
Query: 4573 CYIDTDAEMKDAYKTEYVDHILNNLLEDI-RSLRVEKLTGAETATLEHYICHTVTEVLIK 4749
CY+DT+ EMK+ Y + ++ + N L DI R+ + LE Y+ V ++
Sbjct: 1439 CYVDTEVEMKEIYTSNHMWKLFENFLVDICRACNNTSDRKHADSILEKYVTEIVMSIVTT 1498
Query: 4750 FFEAPYSALQQAKVDVHHHKKTFSEVLLEL--TYLEKGKLRGSKSSRNWYRVAECIKRLT 4923
FF +P+S + + F ++L + Y + K+S V CI+ L+
Sbjct: 1499 FFSSPFS---DQSTTLQTRQPVFVQLLQGVFRVYHCNWLMPSQKAS-----VESCIRVLS 1550
Query: 4924 KWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGHRLYGT 5103
A+ I +P L + V + ++ S + + RL+ +N L +
Sbjct: 1551 DVAKSRAIAIPVDL-------DSQVNNLFLKSHSIVQKTAMNWRLSARNAARRDSVLAAS 1603
Query: 5104 SNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCA 5283
+ N++ ++ + L PL AE SVLV+VLH PELLFPE + R +C
Sbjct: 1604 RD------YRNIIERLQDIVSALEDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKCE 1657
Query: 5284 RGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKM 5385
GG + KLI+H K L++ ++ LC +VLQTL +M
Sbjct: 1658 SGGFICKLIKHTKQLLEENEEKLCIKVLQTLREM 1691
Score = 619 bits (1596), Expect = e-175
Identities = 380/1014 (37%), Positives = 556/1014 (54%), Gaps = 25/1014 (2%)
Frame = +1
Query: 5560 ERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMK 5739
E L +QC L+ GAS+LV D+I+ S +F ++I LA ALL GN +QHSF+ R+
Sbjct: 1797 EMSLAEVQCHLDKEGASNLVIDLIMNASSDRVFHESILLAIALLEGGNTTIQHSFFCRLT 1856
Query: 5740 QKDIHEPFFKAILTRIQTAQNRLKSDM-MSCSDSKPK-----VSLSATVSRRSSTVLTPL 5901
+ E FFK R++ AQ +K+ + ++ SD K V A +++ T +
Sbjct: 1857 EDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPTTQI 1916
Query: 5902 IDAGDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPE--V 6075
+ L E R + + D H P +K+ D L +
Sbjct: 1917 TEE----VRDQLLEASAATRKAFTTFRREADPD-DHYQPGEGTQATADKAKDDLEMSAVI 1971
Query: 6076 ALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFG- 6252
+++PILR LQLLCENHN LQNFLR Q+++TN+NLV ETL FLD +CGST G LG+ G
Sbjct: 1972 TIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGL 2031
Query: 6253 EIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQE-NGLNIIISLVLNEIKPLADDHME 6429
I E N +LI QTL +LTE+CQGPCHENQN +A E NG++II +L+LN
Sbjct: 2032 YINEKNVALINQTLESLTEYCQGPCHENQNCIATHESNGIDIITALILN----------- 2080
Query: 6430 LALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHM 6609
+I K + ++E L+N A+ K L+ ++ ++ N+ +
Sbjct: 2081 ---DINPLGKKRMDLVLE-----------LKNNAS-----KLLLAIMESRHDSENAERIL 2121
Query: 6610 LKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFND 6789
++L ++ KK+ Q V +D N
Sbjct: 2122 YNMRPKELV-----EVIKKAYMQGEVE--------------------------FEDGENG 2150
Query: 6790 DDIPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEI 6969
+D + PR VGHNIYILAHQLA H+ EL+ L + D EAL +Y + TAQIEI
Sbjct: 2151 ED-GAASPRNVGHNIYILAHQLARHNKELQSMLKPGGQVDGD---EALEFYAKHTAQIEI 2206
Query: 6970 VRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQR 7149
VR DRT+E++VFP+ IC +LTK++K +Y TERD QGSK+ +FF E +++EM WQ+
Sbjct: 2207 VRLDRTMEQIVFPVPSICEFLTKESKLRIYYTTERDEQGSKINDFFLRSEDLFNEMNWQK 2266
Query: 7150 KLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSIS---LGNLYSWFA 7320
KL+ + L WCA + W+ +SF+ A ++N LVA +YP ++ G L++
Sbjct: 2267 KLRAQPVLYWCARNMSFWSSISFNLAVLMNLLVAFFYPFKGVRGGTLEPHWSGLLWTAML 2326
Query: 7321 VFSSFLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVA 7500
+ + ++A H +G+ TL++ G + NKI+ +++
Sbjct: 2327 ISLAIVIALPKPHG-------IRALIASTILRLIFSVGLQPTLFLLGAFNVCNKIIFLMS 2379
Query: 7501 FVSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVI 7680
FV N G R ++ Y L+YL IC +GL VH Y +LLFD+++ EETL NVI
Sbjct: 2380 FVGNCGTFTRGYRAMVLDVEFLYHLLYLVICAMGLFVHEFFYSLLLFDLVYREETLLNVI 2439
Query: 7681 ASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSS------ATISSG 7842
SVTRN +SI+ T +LALIL+Y FSI+G+L+F+ DF LEVD + N+++ + S
Sbjct: 2440 KSVTRNGRSIILTAVLALILVYLFSIVGYLFFKDDFILEVDRLPNETAVPETGESLASEF 2499
Query: 7843 IPSETC---PSEGCPGLQPSXX---XXXXXXXXXXSCETLWMCILQTGYQGLRNGGGIGD 8004
+ S+ C E C P +CETL MCI+ GLR+GGG+GD
Sbjct: 2500 LFSDVCRVESGENCSSPAPREELVPAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGD 2559
Query: 8005 VLRNPAPWEDMFIWRVAYDMTXXXXXXXXXXXXXXXXXXDTFGDLRAEKNEKEQILKNNC 8184
VLR P+ E +F RV YD+ DTF DLR+EK +KE+ILK C
Sbjct: 2560 VLRKPSKEEPLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTC 2619
Query: 8185 FICGLDRSRFDNRSVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRN 8364
FICGL+R +FDN++VTFE H + EHN+WHYL +IV++++KD TE+TGPESYVA+ +K+RN
Sbjct: 2620 FICGLERDKFDNKTVTFEEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERN 2679
Query: 8365 LDWFPRMQALSLQDSELDTDQSEVKQMKDQLLQMMTLMREIISQNEESRAFMEQ 8526
LDWFPRM+A+SL S+ + +Q+E++ ++++L M L+ + Q E + M +
Sbjct: 2680 LDWFPRMRAMSLVSSDSEGEQNELRNLQEKLESTMKLVTNLSGQLSELKDQMTE 2733
>gi|47219802|emb|CAG03429.1| unnamed protein product [Tetraodon
nigroviridis]
Length = 2747
Score = 980 bits (2534), Expect = 0.0
Identities = 659/1833 (35%), Positives = 975/1833 (52%), Gaps = 72/1833 (3%)
Frame = +1
Query: 109 LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
LHIGDI+SLY E S N GF+STLGLVDDRC+V+ G +PPKKFRDCLFKVCP+N
Sbjct: 9 LHIGDIVSLYAEGSVN----GFISTLGLVDDRCVVQPDAGDLANPPKKFRDCLFKVCPMN 64
Query: 289 RYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQ 468
RY+AQK W + K+ + G+S DL KL+ AA+ E+++NESE +K LG V++Y +++Q
Sbjct: 65 RYSAQKQFW-KAKQGKQGNSNTQGDLFKKLQHAAELEQKQNESENKKLLGEVVKYSNVIQ 123
Query: 469 LLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKI 648
LLH+KSNK++TV K PA E+NAM+V LD AGNEGSWF I+P +K + GDNV G+K+
Sbjct: 124 LLHIKSNKFLTVNKRLPALLEKNAMRVSLDPAGNEGSWFYIQPFWKLRSEGDNVVVGDKV 183
Query: 649 SLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSV 828
L+P AG LH S+ LLD+ EVN +N T W++ +F+ F + +++ +
Sbjct: 184 VLMP-----VNAG---QPLHASNIELLDNPGCKEVNAVNCNTSWKITLFMKFSDYKEDVL 235
Query: 829 KSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTN 1008
K GDVVRLFHA+Q+ FLT D +Q VFLR T R SA ATSS+ALWEV+VV +
Sbjct: 236 KGGDVVRLFHAEQEKFLTCDEHRRQQH----VFLRTTLRQSATSATSSKALWEVEVVHYD 291
Query: 1009 AYRGGTAKWNKAYRFKHLATDMYLSAE--PSQVQVKPAMNG-RRASLIYSKTNNPMAMYS 1179
RGG +WN +RFKHLAT YL+AE P A G +++SK + A
Sbjct: 292 PCRGGAGQWNSLFRFKHLATGNYLAAEVNPEFKDNTTAPRGENETDVVFSKRKHQAA--- 348
Query: 1180 DGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYV 1359
E T ++P D LF+LD +T +++ VPR SYV
Sbjct: 349 --------EKITFTLVSVPH------------GNDIASLFELDATTLQRADCLVPRNSYV 388
Query: 1360 RLLHQSSDKWVHATNATEKQNLHYSSKNEKGWVKVICEKNRVDKETFALLPVNPDEVRDL 1539
RL H ++ WV +TN + + +K+ + DKE FA++ V EVRDL
Sbjct: 389 RLRHLCTNTWVTSTNVPID-----TEEERPVMLKIGTCPAKEDKEAFAIVSVPLSEVRDL 443
Query: 1540 DFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSP 1719
DFANDA K L + ++ ++ G + E T+LL D + FV ++ D L + +P
Sbjct: 444 DFANDASKVLESTVRKLQYGTITQNER-RFVTKLLEDLVFFVCVVPNNGQDVLSVVTSTP 502
Query: 1720 SRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIFKTMFQLCY 1899
+R+RQKL+REQ +L Q+F +LKAPF T D R FK M +LCY
Sbjct: 503 NRERQKLMREQNILAQIFGILKAPF-----TDQGDGPILRLEDLGDQRYAHFKYMLRLCY 557
Query: 1900 CLLKYSQVSYRKN--------------QEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNP 2037
+L++SQ YRKN QE++A+KF +Q QIG++++AEDT+TA+LHNN
Sbjct: 558 RVLRHSQQDYRKNQAGVVAIMWSFSALQEYIAKKFTIMQSQIGYEILAEDTITALLHNNR 617
Query: 2038 KLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRD 2217
KLLEK++ +E FV L+R NR+ +FLDYL+DLCV A QELIC +L+ + D
Sbjct: 618 KLLEKHITAREIETFVNLLRRNREPRFLDYLSDLCVSNKTAIPVTQELICKFMLNPTNAD 677
Query: 2218 IFMDTKII-----------------DGEIEVGW-----APNFRKLVDIAEGAKS-NSDDA 2328
I + TK+I + E+ + W P+ + + +A+ AK + D
Sbjct: 678 ILIQTKLIANTETTLESSLLQEEVEEEEVWLYWIDSHKEPHGKSIRHLAQDAKGIHKMDV 737
Query: 2329 EHLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRG 2508
+ + YYR+QL+L ++MC ++QYLAI+ +S QLP +L+L+CM D+ LPY+LR
Sbjct: 738 DIITYYRYQLNLFAKMCLDRQYLAIN--------QVSCQLPVDLILRCMFDDCLPYNLRA 789
Query: 2509 SFTRLMLHLHVVRGSPMSA--IRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGI 2682
SF RLMLH+HV R S +R+ARLW IP + + +E S +D SR +
Sbjct: 790 SFCRLMLHMHVDRDPQESVVPVRYARLWTEIPSKITIHEFEYES----TDTSREEMKRKF 845
Query: 2683 AHKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNL 2862
A + VE YL + +Q + ++LT E+VNLA+ L F FYSF++LL+LT+ L
Sbjct: 846 A-PTMEFVEEYLRDVVSQPFPFGDK-DKNELTLEVVNLARNLVYFGFYSFSELLRLTRTL 903
Query: 2863 LAI-------------INEGPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPS 3003
LAI +N+ P E + ++ + M M+ +S L TP
Sbjct: 904 LAILDIVQHPLSLINKLNKSP--EAGNNVLRTIHGVGEMMTQMVMSRGVPHS--LTDTPP 959
Query: 3004 VTAEEAGR--TKEGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCD---ED 3168
G + + + TKL + EILQF++ VR DYRIT LS +K F + E+
Sbjct: 960 SLRYGKGYFFSDNEDVMVMDTKLKIIEILQFILSVRLDYRITYLLSIYKKEFGDNSIVEN 1019
Query: 3169 GSLMHSASINERMASE--------LYDAIYRSSGH--ELHLDGRDGQLLLAILLQMTMSD 3318
S + ASE + ++ S + LD G+ L +L+ + M +
Sbjct: 1020 SMADCSTMLLFTPASEPDIDEITTKAETMFAGSSELSAVELDDEGGRTFLRVLIHLIMQE 1079
Query: 3319 YPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSEL 3498
YPPL S +L++ F+HF+Q E+L+ KQVQLLVS DVENY+QI DL L+ EKSEL
Sbjct: 1080 YPPLVSGSLQLLFKHFSQRAEVLQAFKQVQLLVSEQDVENYKQIKTDLDQLRLTVEKSEL 1139
Query: 3499 WVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNE 3678
WV ++ + V + + E +L SP
Sbjct: 1140 WVEKSGAYNGEDLAVRQGKEPNEEGVL-----SP-------------------------- 1168
Query: 3679 CLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDPKPDTMNQ 3858
++D N + + ++ Y +++++L+RL+ +CY K Q
Sbjct: 1169 ---------VQDGDNKPQIDSNKANN------YKIVKEILLRLSKLCY--PSKKSRVQQQ 1211
Query: 3859 QLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYE 4038
+LLKNM + VVL+ + +P++K D M +++TL+H FL++FC+ N +NQ L+K ++
Sbjct: 1212 RLLKNMGAHTVVLDLLQIPYEKS-DEKMNEIMTLAHTFLQNFCRGNPQNQVLLHKHLNL- 1269
Query: 4039 KDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQA 4218
G+L ET+ IF NN +L + + + ++ H V IE + ++ +L+ L+
Sbjct: 1270 -FLTPGLLEAETMRH------IFMNNYQLCNEISDRVVHHFVHCIETHGKHVQYLKFLET 1322
Query: 4219 LVCVYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRK 4398
+V K ++ Q+KV E+ ++V Y D +SF L MM E+E +D
Sbjct: 1323 IVKADGKYVKKCQDKVMTELVNGGEDVLVFYNDRSSFPVLLQMMGSERE----RTDEDGA 1378
Query: 4399 LKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCY 4578
L YH LV LLA CT GKN TELKC S +P+D IVRVVT C+ EVKT Y+ + HCY
Sbjct: 1379 LAYHNTLVELLAACTEGKNVYTELKCNSLLPLDDIVRVVTDIHCVPEVKTAYVNFVNHCY 1438
Query: 4579 IDTDAEMKDAYKTEYVDHILNNLLEDIRSL--RVEKLTGAETATLEHYICHTVTEVLIKF 4752
+DT+ EMK+ Y + ++ + +N L D+ S + A++A LE Y+ TV ++ F
Sbjct: 1439 VDTEVEMKEIYTSNHIWKLFDNFLVDMSSACNTTTERNHADSA-LEKYVTETVMAIVKGF 1497
Query: 4753 FEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGKLRGSKSSRNWYRVAECIKRLTKWA 4932
F +P+S ++ ++ F ++L + + N + CIK L A
Sbjct: 1498 FSSPFSV---NHANLQTNQSIFIKLLQSSFRIYNCTWLSAPQKAN---IESCIKTLADVA 1551
Query: 4933 EEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGHRLYGTSNS 5112
+ I +P L + V Q A+ R ++ P +R
Sbjct: 1552 KARAIAIPVDLDSQVNTLSLKVHSTMVQRAAKDWRTSARSRPRKEPLGGPDYR------- 1604
Query: 5113 MTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCARGG 5292
N++ ++ + P AE SVLV+VLH+PELLFPE + L C G
Sbjct: 1605 -------NIIEKLQGVVSLLEEQFSPKVQAEFSVLVDVLHSPELLFPEAAQL---CESGA 1654
Query: 5293 VVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCD 5391
++KLI+H K LM +K++ LC ++LQTL +M D
Sbjct: 1655 FMSKLIKHTKKLM-DKEEKLCIKILQTLREMLD 1686
Score = 613 bits (1582), Expect = e-173
Identities = 353/871 (40%), Positives = 500/871 (56%), Gaps = 49/871 (5%)
Frame = +1
Query: 6061 LPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSL 6240
+ P +A+++PILR LQLLCENHNS LQNFLR Q+++TN+NLV ETL FLD +CGST G L
Sbjct: 1904 MSPAIAIMKPILRFLQLLCENHNSELQNFLRNQNNKTNYNLVCETLQFLDCICGSTTGGL 1963
Query: 6241 GVFG-EIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQE-NGLNIIISLVLNEIKPLA 6414
G+ G I E N LI QTL T+TE+CQGPCHENQ +A E NG++III+L++N I PL
Sbjct: 1964 GLLGLYINESNVDLIRQTLETITEYCQGPCHENQTCIAKHESNGIDIIIALIVNPINPLG 2023
Query: 6415 DDHMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTN 6594
+ ++L LE+K+ ASKLLLAIMESRHD ENA ++L M P +LV +A+
Sbjct: 2024 KNRLDLVLELKNNASKLLLAIMESRHDSENAEKILYKMR-----PNELVGEQVRAHTWAG 2078
Query: 6595 SNHHMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLD 6774
++ P +T+ V ++ +A +T+ S D
Sbjct: 2079 AD------------------------PVLTLACVAQVDVMKEA------YTQGLQSEEED 2108
Query: 6775 DKFNDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWL---DGSDEKKDDLTREALNYYK 6945
D D + PR+VGHNIYILAHQLA H L+ L GS D+ +AL+YY
Sbjct: 2109 DGVGDQ----IKPRDVGHNIYILAHQLARHSKVLQQSLKPGSGSPFDPDNEKDDALHYYA 2164
Query: 6946 ERTAQIEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETM 7125
TAQIEIVRRDRT+E++VFP+ +IC YLT+++ V+ TERD+QGSKV +FF +++ +
Sbjct: 2165 NHTAQIEIVRRDRTMEQIVFPVPNICEYLTEESMVRVFTTTERDDQGSKVNDFFQQFDNL 2224
Query: 7126 YHEMIWQRKLQDRKW----------------------------------------LSWCA 7185
Y+EM WQ+K++ + L W +
Sbjct: 2225 YNEMRWQKKIRSKASYTESTSCQMVMAVTGGGQSRLTVVVPDDELLFAVYAENIALFWFS 2284
Query: 7186 FRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSI--SLGNLYSWFAVFSSFLLAHYLRH 7359
+ LW +SF+ A +VN VA +YP + + N+ W A+ +L L
Sbjct: 2285 RNISLWGSISFYLACLVNIAVAVFYPFGDDGDEGTLSPFWNILLWVALGVFSILLPVLPK 2344
Query: 7360 DKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIA 7539
+ L +G+ L + G L NK+V +V+FV N+G R
Sbjct: 2345 PQGILF-----FLVSLILRSIYTLGLGPALLLLGTSNLFNKLVFLVSFVGNQGTFTRGYK 2399
Query: 7540 EILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIVWT 7719
++ Y + Y IC+LGLLVH Y LLFD++ EETL NVI SVTRN +SI+ T
Sbjct: 2400 AVVMDMLFIYHMSYAIICVLGLLVHEFFYSFLLFDLVIREETLLNVIKSVTRNGRSIILT 2459
Query: 7720 GLLALILLYFFSILGFLYFRHDFYLEVD--PVENDSSATISSGIPSETCPSEGCPGLQPS 7893
+LAL L+YFFSI+GFL+ + DF +EVD P + IP E +E C +
Sbjct: 2460 AILALFLVYFFSIIGFLFLKDDFRMEVDRLPAPEIKDLFKNQKIP-EAYSNEIC-----T 2513
Query: 7894 XXXXXXXXXXXXSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTXX 8073
C+TL+MCI+ QGLRNGGG+GD+LR P+ E +F RV YD+
Sbjct: 2514 KPVADEDDGMERVCDTLFMCIITVLNQGLRNGGGVGDILRRPSKAEPLFAARVVYDLLFF 2573
Query: 8074 XXXXXXXXXXXXXXXXDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRET 8253
DTF DLR+EK KE+ILK CFICGL+R +FDN++VTFE H ++
Sbjct: 2574 FVVIIIVLNLIFGVIIDTFADLRSEKQRKEEILKTTCFICGLERDKFDNKTVTFEEHIKS 2633
Query: 8254 EHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSE 8433
EHN+WHYLY++V++++KD TE+TGPESYVAQ + ++NL+WFPRM+A+SL +E + +Q+E
Sbjct: 2634 EHNMWHYLYFLVLVRVKDPTEYTGPESYVAQMIAEKNLEWFPRMRAMSLVSNEGEGEQNE 2693
Query: 8434 VKQMKDQLLQMMTLMREIISQNEESRAFMEQ 8526
++ ++++L +TL+ ++ +Q E + M +
Sbjct: 2694 MRCLQEKLSDTVTLVAQLSAQLSELKEQMTE 2724
>gi|50754604|ref|XP_414438.1| PREDICTED: similar to inositol
1,4,5-trisphosphate receptor type 1 [Gallus gallus]
Length = 3466
Score = 921 bits (2380), Expect = 0.0
Identities = 645/1836 (35%), Positives = 949/1836 (51%), Gaps = 128/1836 (6%)
Frame = +1
Query: 262 CLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGN 441
CLFK+CP+NRY+AQK W K +S D L+NKL AAD E+++NE+E +K LG
Sbjct: 743 CLFKLCPMNRYSAQKQFWKAAK--PGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGT 800
Query: 442 VIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIG 621
VIQYG+++QLLH+KSNKY+TV K PA E+NAM+V LD AGNEGSWF I+P YK +IG
Sbjct: 801 VIQYGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIG 860
Query: 622 DNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLL 801
D+V G+K+ L P AG LH SS L+D+ EVN +N T W++ +F+
Sbjct: 861 DSVVIGDKVVLNP-----VNAGQ---PLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMK 912
Query: 802 FDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRAL 981
+ +N+ + +K GDVVRLFHA+Q+ FLT D K+ VFLR T R SA ATSS+AL
Sbjct: 913 WSDNKDDILKGGDVVRLFHAEQEKFLTCDEHRKKQH----VFLRTTGRQSATSATSSKAL 968
Query: 982 WEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRRASLIYSKTNN 1161
WEV+VVQ + RGG WN +RFKHLAT YL+AE V P Y + +
Sbjct: 969 WEVEVVQHDPCRGGAGYWNSLFRFKHLATGHYLAAE-----VNPD---------YEEDDQ 1014
Query: 1162 PMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEV 1341
D + + Q+ + V P + D + +F+LDP+T + V
Sbjct: 1015 ECQSSQDPEQDASRRGLRSAQEKMAYSLVSVPEGN-----DISSIFELDPTTLRGGDSLV 1069
Query: 1342 PRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKG-WVKVICEKNRVDKETFALLPVN 1518
PR SYVRL H ++ WVH+TN + + EK +K+ + DKE FA++PV+
Sbjct: 1070 PRNSYVRLRHLCTNTWVHSTN------IPIDKEEEKPVMLKIGTSPVKEDKEAFAIVPVS 1123
Query: 1519 PDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADPL 1698
P EVRDLDFANDA K L + ++ G + E S T+LL D + FVT ++ D L
Sbjct: 1124 PAEVRDLDFANDASKVLGSIAGKLEKGTITQNER-RSVTKLLEDLVYFVTGGTNSGQDVL 1182
Query: 1699 KISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIFK 1878
++ P+R+RQKL+REQ +L Q+F LL+APF T D R+ F+
Sbjct: 1183 EVVFSKPNRERQKLMREQNILKQIFKLLQAPF-----TDSGDGPMLRLEELGDQRHAPFR 1237
Query: 1879 TMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYV 2058
+ +LCY +E++A++FG +Q+QIG+D++AEDT+TA+LHNN KLLEK++
Sbjct: 1238 HICRLCY-------------REYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKHI 1284
Query: 2059 KTPHVERFVELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKI 2238
++ FV LVR NR+ +FLDYL+DLCV ++ QELIC +VL+ + DI ++TK+
Sbjct: 1285 TAAEIDTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPANADILIETKL 1344
Query: 2239 I------------DGEIEVG---------WAPNFRKLV-----DIAEGAKSNS-DDAEHL 2337
+ + +EVG W + +++ ++A+ AK +D + L
Sbjct: 1345 VLSRFEFEEVSSGENALEVGEDEEEVWLFWRDSNKEIRSKSIRELAQDAKEGQKEDRDVL 1404
Query: 2338 DYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFT 2517
YYR+QL+L ++MC ++QYLAI+ IS QL +L+L+CMSD LPYDLR SF
Sbjct: 1405 SYYRYQLNLFARMCLDRQYLAIN--------EISGQLDVDLILRCMSDENLPYDLRASFC 1456
Query: 2518 RLMLHLHVVRG--------------SPMSAI---------RHARLWWSIPENVNVSTYES 2628
RLMLH+HV R + SAI + W + Y+S
Sbjct: 1457 RLMLHMHVDRDPQEQSSDSSKLIVHTAASAINSRNKGKMQKQVMCWIQSCCLIANGNYDS 1516
Query: 2629 VSVEAYSDGSRMRIGEGIAHKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKAL 2808
S S+ I E A + + VE YL + Q +KLT+E+VNLA+ L
Sbjct: 1517 ------SGTSKDEIKERFA-QTMEFVEEYLRDVVCQRFPFSDK-EKNKLTFEVVNLARNL 1568
Query: 2809 AQFNFYSFNDLLQLTQNLLAIIN--------------EGPATEQVPSHRAMVNAIRNMSK 2946
F FY+F DLL+LT+ LLAI++ +G ++ R++ M++
Sbjct: 1569 IYFGFYNFCDLLRLTKILLAILDCVHITTIFPITKMAKGEESKGSNVMRSIHGVGELMTQ 1628
Query: 2947 SMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKTKLIVAEILQFVMDVRRDYRITM 3126
++RGG LA P ++ KE L + TKL + EILQF+++VR DYRI+
Sbjct: 1629 VVLRGGGFLPMTPLAAAPEGNVKQTEPEKED-ILVMDTKLKIIEILQFILNVRLDYRISC 1687
Query: 3127 ALSWFKNVFPCDEDGSLMHSA---SINERMASELYDAI---------------YRSSGHE 3252
L FK+ F DE + M + S ++ M + + A+ + S HE
Sbjct: 1688 LLCIFKHEF--DESNAQMSESPTGSSSQEMPANVPGALDFEHIEEQAEGIFGGRKVSLHE 1745
Query: 3253 ----LHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVS 3420
L LD G+ L +LL +TM DYPPL S AL++ FRHF+Q QE+L+ KQVQLLV+
Sbjct: 1746 ENTPLDLDDHGGRTFLRVLLHLTMHDYPPLVSGALQLLFRHFSQRQEVLQAFKQVQLLVT 1805
Query: 3421 NNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSP 3600
+ DV+NY+QI +DL L+++ EKSELWV+ + + +D EH +
Sbjct: 1806 SQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQG---PDETMDGVPGENEHKKKEEG---- 1858
Query: 3601 RAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYP 3780
H S + E N ++K+
Sbjct: 1859 ------------------HSKSQKPESTSSYNYRVVKE---------------------- 1878
Query: 3781 LIRQMLVRLTGMCYRKGDP--KPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHD----- 3939
+L+RL+ +C ++ K Q+LL+NM + VVLE + +P++K + D
Sbjct: 1879 ----ILLRLSKLCVQESASVRKSRKQQQRLLRNMGAHAVVLELLQIPYEKSWNWDSSSAH 1934
Query: 3940 ------------------------MMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDA 4047
M +++ L+HEFL++FC N++NQ+ L+K I+
Sbjct: 1935 LQVNLQILCNSIVFVMQSQAEDTRMQEIMKLAHEFLQNFCAGNQQNQALLHKHIN----- 1989
Query: 4048 KEGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVC 4227
+ I E T+ IF NN +L S + E ++ H V IE + RN +++ LQ +V
Sbjct: 1990 ---LFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVK 2046
Query: 4228 VYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKY 4407
K I+ Q+ + N A ++V Y D ASF+ L MM+ E++ D L Y
Sbjct: 2047 AEGKFIKKCQDMLVN----AGEDVLVFYNDRASFQTLVQMMRSERD----RMDENSPLMY 2098
Query: 4408 HIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDT 4587
HI LV LLA+CT GKN TE+KC S +P+D IVRVVT + C+ EVK Y+ L HCY+DT
Sbjct: 2099 HIHLVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCYVDT 2158
Query: 4588 DAEMKDAYKTEYVDHILNNLLEDI-RSLRVEKLTGAETATLEHYICHTVTEVLIKFFEAP 4764
+ EMK+ Y + ++ + N L DI R+ + LE Y+ V ++ FF +P
Sbjct: 2159 EVEMKEIYTSNHMWKLFENFLVDICRACNNTSDRKHADSILEKYVTEIVMSIVTTFFSSP 2218
Query: 4765 Y---SALQQAKVDVHHHKKTFSEVLLELTYLEKGKLRGSKSSRNWY------RVAECIKR 4917
+ S Q ++ + K+T V ++L +G R NW V CI+
Sbjct: 2219 FSDQSTTLQTQI-LTRIKETRQPVFVQLL---QGVFRVYHC--NWLMPSQKASVESCIRV 2272
Query: 4918 LTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGHRLY 5097
L+ A+ I +P L + Q+ A + W + R++++ R Y
Sbjct: 2273 LSDVAKSRAIAIPVDLDSQVNNLFLKSHNIVQKTAMN--WRMTARNAARRDSVLAASRDY 2330
Query: 5098 GTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQ 5277
N++ ++ + L PL AE SVLV+VLH PELLFPE + R +
Sbjct: 2331 -----------RNIIERLQDIVSALEDRLRPLVQAELSVLVDVLHRPELLFPENTDARRK 2379
Query: 5278 CARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKM 5385
C GG + KLI+H K L++ ++ LC +VLQTL +M
Sbjct: 2380 CESGGFICKLIKHTKQLLEENEEKLCIKVLQTLREM 2415
Score = 451 bits (1161), Expect = e-124
Identities = 299/836 (35%), Positives = 442/836 (52%), Gaps = 24/836 (2%)
Frame = +1
Query: 5560 ERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMK 5739
E L +QC L+ GAS+LV D+I+ S +F ++I LA ALL GN +QHSF+ R+
Sbjct: 2636 EMSLADVQCHLDKEGASNLVIDLIMNATSDRVFHESILLAIALLEGGNTTIQHSFFCRLT 2695
Query: 5740 QKDIHEPFFKAILTRIQTAQNRLKSDM-MSCSD--SKPKVSLSATVSRRSSTVLTPLIDA 5910
+ E FFK R++ AQ +K+ + ++ SD +K K S V P+
Sbjct: 2696 EDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDEDSDRDVPNRKRVREPMTQI 2755
Query: 5911 GDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQ-DEEKSTDALPPEVALVE 6087
+ L E R + + +D +S + A D+ K + +++++
Sbjct: 2756 TEE-VRDQLLEASAATRKAYSTYRREADSDDHYSAAEGAQSAADKSKDDLEMSAVISIMQ 2814
Query: 6088 PILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFG-EIGE 6264
PILR LQLLCENHN LQNFLR Q+++TN+NLV ETL FLD +CGST G LG+ G I E
Sbjct: 2815 PILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINE 2874
Query: 6265 HNFSLITQTLATLTEFCQGPCHENQNTMAMQE-NGLNIIISLVLNEIKPLADDHMELALE 6441
N +LI QTL +LTE+CQGPCHENQN +A E NG++II +L+LN +
Sbjct: 2875 KNVALINQTLESLTEYCQGPCHENQNCIATHESNGIDIITALILN--------------D 2920
Query: 6442 IKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSI 6621
I K + ++E L+N A+ K L+ ++ ++ N+ +
Sbjct: 2921 INPLGKKRMDLVLE-----------LKNNAS-----KLLLAIMESRHDSENAERILYNMR 2964
Query: 6622 SRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIP 6801
++L ++ KK+ Q V +D N +D+
Sbjct: 2965 PKELV-----EVIKKAYLQGEVE--------------------------FEDGENGEDL- 2992
Query: 6802 SVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRD 6981
+ PR VGHNIYILAHQLA H+ EL+ L + + D EAL +Y + TAQIEIVR D
Sbjct: 2993 AASPRNVGHNIYILAHQLARHNKELQNMLKPGGQIEGD---EALEFYAKHTAQIEIVRSD 3049
Query: 6982 RTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQD 7161
RT+E++VFP+ +IC +LTK++K +Y TERD QGSK+ +FF + E +++EM WQ+KL+
Sbjct: 3050 RTMEQIVFPVPNICEFLTKESKLRIYYTTERDEQGSKINDFFMKSEDLFNEMNWQKKLRA 3109
Query: 7162 RKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSIS---LGNLYSWFAVFSS 7332
+ +L WCA + W+ +SF+ A ++N LVA +YP ++ G L++ + +
Sbjct: 3110 QPFLYWCARNMSFWSSISFNLAVLMNLLVAFFYPFKGIRGGTLEPHLSGLLWTAMLISLA 3169
Query: 7333 FLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVAFVSN 7512
++A H +G+ TL++ G + NKI+ +++FV N
Sbjct: 3170 IVIALPKPHG-------IRALIASTILRLIFSVGLQPTLFLLGAFNVCNKIIFLMSFVGN 3222
Query: 7513 KGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVT 7692
G R ++ Y L+YL IC LGL VH Y +LLFD+++ EETL NVI SVT
Sbjct: 3223 CGTFTRGYKAMIMDVEFLYHLLYLLICALGLFVHEFFYSLLLFDLVYREETLLNVIKSVT 3282
Query: 7693 RNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDS---------SATISSGI 7845
RN +SI+ T +LALIL+Y FSI+G+L+F+ DF LEVD + N++ +
Sbjct: 3283 RNGRSIILTAVLALILVYLFSIVGYLFFKDDFILEVDKLPNETLLPDRTEPGETMTGEFL 3342
Query: 7846 PSETC---PSEGCPGLQPS---XXXXXXXXXXXXSCETLWMCILQTGYQGLRNGGG 7995
S+ C SE C + PS +CETL MCI+ GLR+GGG
Sbjct: 3343 YSDVCKAGSSENCSSIIPSDQLIAEEMEEENKEHTCETLLMCIVTVLSHGLRSGGG 3398
Score = 68.2 bits (165), Expect = 3e-09
Identities = 36/76 (47%), Positives = 47/76 (61%)
Frame = +1
Query: 109 LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
LHIGDI SLY E S+N GF+STLGLVDDRC+V+ + G +PPKKFR+ +
Sbjct: 324 LHIGDICSLYAEGSTN----GFISTLGLVDDRCVVQPEAGDLNNPPKKFREANAMQRRAD 379
Query: 289 RYAAQKHLWTEQKRFQ 336
A K W ++ F+
Sbjct: 380 AKGADKMQWKIKRNFK 395
>gi|47229530|emb|CAG06726.1| unnamed protein product [Tetraodon
nigroviridis]
Length = 2336
Score = 910 bits (2353), Expect = 0.0
Identities = 645/1870 (34%), Positives = 953/1870 (50%), Gaps = 131/1870 (7%)
Frame = +1
Query: 1366 LHQSSDKWVHATNATE---KQNLHYSSKNEKGWVKVICEKNRVDKETFALLPVNPDEVRD 1536
LH S+ + V E + H SK +GW +C PV+P EVRD
Sbjct: 134 LHASTHQLVDNPGCNEGLSATDRHLCSKRGQGWPLPLC-------------PVSPAEVRD 180
Query: 1537 LDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFS 1716
LDFANDA K L + ++ G + E + T+LL D + FV + + D L+I
Sbjct: 181 LDFANDASKVLASIAGKLEKGTITQNER-RAVTKLLEDLVFFVVDIPNSGQDVLEIMVNK 239
Query: 1717 PSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIFKTMFQLC 1896
P+R+RQKL+REQ +L Q+F LL+APF T D R+ F+ + +LC
Sbjct: 240 PNRERQKLMREQNILKQIFKLLQAPF-----TDSGDGPMLRLEELADQRHAPFRHICRLC 294
Query: 1897 YCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVE 2076
Y +L++SQ YRKNQE++A++F +Q+QIG+D++AEDT+TA+LHNN KLLEK++ ++
Sbjct: 295 YRVLRHSQQDYRKNQEYIAKQFRFMQKQIGYDVLAEDTITALLHNNRKLLEKHITAAEID 354
Query: 2077 RFVELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKIIDGEIE 2256
FV LVR NR+ +FLDYL+DLCV ++ QELIC +VL + DI ++TK++ E
Sbjct: 355 TFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICNAVLDPANADILIETKLVLSRFE 414
Query: 2257 VGWAP---------------------------NFRKLVDIAEGAKSNS-DDAEHLDYYRH 2352
+ AP + + ++A+ AK +D E + YYR+
Sbjct: 415 IEGAPLGENSLESEEDEEEVWLFWKDNNNKEIRSKSIRELAQDAKEGQKEDQEVISYYRY 474
Query: 2353 QLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLH 2532
QL+L ++MC ++QYLAI+ IS QL +L+L+CMSD LP+DLR SF R+MLH
Sbjct: 475 QLNLFARMCLDRQYLAIN--------KISGQLDVDLILRCMSDEDLPFDLRASFCRMMLH 526
Query: 2533 LHVVRG--SPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDG-SRMRIGEGIAHKVLAT 2703
+HV R ++ +++ARLW IP + + Y++ DG S+ I E + + +
Sbjct: 527 MHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDN-------DGTSKDEIKERFS-QTMEF 578
Query: 2704 VETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIIN-- 2877
VE YL + QS +KLT+E+VNLA+ L F FY+F+DLL+LT+ LLAI++
Sbjct: 579 VENYLRDVVCQSFPFADK-EKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCV 637
Query: 2878 ------------EGPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEA 3021
+ ++ R++ MS+ ++RGG T T +
Sbjct: 638 HIGTAFGFNKLDKDDESKGSNVMRSIHGVGELMSQVVLRGGGFLPMTPSISTSRDTVKTQ 697
Query: 3022 GRTKEGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMH------ 3183
++ L + TKL + EILQF+++VR DYRI+ LS FK F DE S
Sbjct: 698 TEPEKQDILVMDTKLKIIEILQFILNVRLDYRISCLLSIFKREF--DESNSQSELPVGGA 755
Query: 3184 -------SASINERMASELYDAIYRSSGHE--LHLDGRDGQLLLAILLQMTMSDYPPLTS 3336
+++ E + I+ S L LD G+ L +LL +TM DYPPL S
Sbjct: 756 VEGPNNMPGALDFEHIEEQAEGIFGGSEENTPLDLDDHGGRTFLRVLLHLTMHDYPPLVS 815
Query: 3337 IALKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDR 3516
AL + FRHF+Q QE+L+ KQVQLLV++ DVENY+QI DL L+++ EKSELWV+
Sbjct: 816 RALHLLFRHFSQRQEVLQAFKQVQLLVTSQDVENYKQIKSDLDQLRSIVEKSELWVY--- 872
Query: 3517 HHSIDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLN 3696
K + +E + D+G+ + C + +
Sbjct: 873 -----------KRQGSEEGM-----------DTGEGL-----------------CAEPEH 893
Query: 3697 RLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKG--DPKPDTMNQQLLK 3870
+L+ + + ++ + + Y +++++L+RL+ +C ++G K Q+LL+
Sbjct: 894 KLVPYFENSLSSKYKTKKPESTSSYNYRVVKEILLRLSKLCVQEGLSGRKSKKQQQRLLR 953
Query: 3871 NMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAK 4050
NM + VVLE + +P++K D M ++ L+H+FL++FC N++NQ+ L+K I+
Sbjct: 954 NMGAHSVVLELLQIPYEKGEDLRMQDIMKLAHQFLQNFCAGNQQNQALLHKHIN------ 1007
Query: 4051 EGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCV 4230
+ I E T+ IF NN +L S + E ++ H V IE + RN +L+ LQ +V
Sbjct: 1008 --LFLNPGILEAITMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYLKFLQTIVKA 1065
Query: 4231 YDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYH 4410
+K I+ Q+ V E+ A ++V Y D ASF+ L MM+ E++ D L YH
Sbjct: 1066 ENKFIKKCQDIVMAELVNAGEDVLVFYNDRASFQTLVQMMRSERD----RMDENSPLMYH 1121
Query: 4411 IELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTD 4590
I LV LLA+CT GKN TE+KC S +P+D IVRVVT + C+ EVK Y+ L HCY+DT+
Sbjct: 1122 IHLVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCYVDTE 1181
Query: 4591 AEMKDAYKTEYVDHILNNLLEDIRSLRVEKLTG----AETATLEHYICHTVTEVLIKFFE 4758
EMK+ Y + ++ + N L DI RV T A+T LE Y+ TV ++ FF
Sbjct: 1182 VEMKEIYTSNHMWKLFENFLVDI--CRVCNSTSDRKHADT-ILERYVTETVMSIVTTFFS 1238
Query: 4759 APYSALQQAKVDVHHHKKTFSEVLLEL--TYLEKGKLRGSKSSRNWYRVAECIKRLTKWA 4932
+P+S + + F ++L + Y + K S V CIK L+ A
Sbjct: 1239 SPFS---DQSTSLQTRQPVFVQLLQAVFRVYHCNWLIPVQKGS-----VENCIKVLSDVA 1290
Query: 4933 EEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGHRLYGTSNS 5112
+ I +P L + Q+ A S W + R++++ R Y
Sbjct: 1291 KGRAIAIPVDLDNQVHNLFVKSNNIVQKTAMS--WRLSARNAARRDSVVTASRDY----- 1343
Query: 5113 MTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCARGG 5292
N++ ++ + L PL AE SVLV+VLH PELLFPE + R +C GG
Sbjct: 1344 ------RNIIERLQDIVSALEDRLRPLVQAELSVLVDVLHRPELLFPENTDSRKKCESGG 1397
Query: 5293 VVAKLIQHCKTLMQNKQDNLCARVLQTLCKM-----------------CDCTK-XXXXXX 5418
+ KLI+H K L++ ++ LC +VLQTL +M D K
Sbjct: 1398 FICKLIKHTKQLLEENEERLCIKVLQTLREMMTKDRGYGEKFRAFDDEMDMPKQNKMGFK 1457
Query: 5419 XXXXXXXXXXRYFGHHNNHHPPLDRQQSXXXXXXXXXXXXXXXTWS----------QERD 5568
RY+G N H R+ S S E
Sbjct: 1458 GEALRQILVNRYYG---NFHRSGGRRDSLTFANSPLSPIGPGRNQSGLGVPGGLSRGEMS 1514
Query: 5569 LYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKD 5748
L +QC L+ GASDLV D+I+ S +F ++I LA ALL GN +Q SF+ R+ +
Sbjct: 1515 LAEVQCHLDKEGASDLVIDLIMNTTSDRVFQESILLAIALLEGGNTTIQRSFFCRLTEDK 1574
Query: 5749 IHEPFFKAILTRIQTAQNRLKS----------DMMSCSDSKPKVSLSATVSRRSSTVLTP 5898
E FF+ R++ AQ +K+ + DS+ K R SS V+T
Sbjct: 1575 KSEKFFRVFYDRMKLAQLEIKATVTVNTSDLGNRKRVDDSQDKDGPVRKKVRESSVVMTE 1634
Query: 5899 LIDAGDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPD-LAPYQDEEKSTDALPPEV 6075
+ L E + S + + ++ D + D+ + + +
Sbjct: 1635 DV-------REQLLEASSATKKAFNSYRREADPEDHFNVADGQSNTGDKNQDDGEMSFVI 1687
Query: 6076 ALVEPILRVLQLLCENHNSLL-------------QNFLRKQSDRTNHNLVSETLSFLDTV 6216
+++PILR LQLLCENHN L QNFLR Q+++ N+NLV ETL FLD +
Sbjct: 1688 VIMQPILRFLQLLCENHNRDLQNLYRIYIFFVPHQNFLRCQNNKNNYNLVCETLQFLDCI 1747
Query: 6217 CGSTKGSLGVFG-EIGEHNFSLITQTLATLTEFCQGPCHEN------QNTMAMQE-NGLN 6372
CGST G LG+ G I E N +LI QTL +LTE+CQGPCHEN QN +A E NG++
Sbjct: 1748 CGSTTGGLGLLGLYINEKNVALINQTLESLTEYCQGPCHENQFVYILQNCIATHESNGID 1807
Query: 6373 IIISLVLNEIKPLADDHMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPK 6552
III+L+LN+I PL M+L LE+K+ ASKLLLAIMESRHD ENA R+L NM PK
Sbjct: 1808 IIIALILNDINPLGKKRMDLVLELKNNASKLLLAIMESRHDSENAERILYNMR-----PK 1862
Query: 6553 QLVHAIKQAY 6582
+LV IK+AY
Sbjct: 1863 ELVEVIKKAY 1872
Score = 164 bits (414), Expect = 5e-38
Identities = 99/296 (33%), Positives = 153/296 (51%), Gaps = 12/296 (4%)
Frame = +1
Query: 7150 KLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSISLG-NLYSWFAVF 7326
+L+ + L WC+ + +W+ + F+ A ++N LV +YPL + + W VF
Sbjct: 1915 QLEAQPVLYWCSRNMSVWSNICFNLALLMNLLVCLFYPLEGVQGVMLDPHLSAMLWMGVF 1974
Query: 7327 SSFLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVAFV 7506
++ ++ + + +G+ TL++ G + NKI+ +++FV
Sbjct: 1975 AALVIVLVMPQQL-----SVRALVIITILRLIFSVGLEPTLFLLGAFNVCNKIIFLISFV 2029
Query: 7507 SNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIAS 7686
N+G R ++ Y L+YL IC LG+ VH Y +LLFD+++ EETL NVI S
Sbjct: 2030 GNRGTFTRGYKAMVLDFEFLYHLIYLIICCLGVFVHVFFYSLLLFDLVYREETLLNVIKS 2089
Query: 7687 VTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSG--IPSETC 7860
VTRN +SIV T +LALIL+Y FSI+G+++F+ DF LEVD V N ATI G + S
Sbjct: 2090 VTRNGRSIVLTAVLALILVYLFSIVGYIFFKDDFILEVDRVPN---ATIKGGGSLASVFV 2146
Query: 7861 PSEGCPG---------LQPSXXXXXXXXXXXXSCETLWMCILQTGYQGLRNGGGIG 8001
P+ C G Q +C++L MCI+ GLR+GGG+G
Sbjct: 2147 PTGMCQGGIDQNCTAKAQLEEDNKDKDDDVERTCDSLLMCIVTVLSHGLRSGGGVG 2202
Score = 127 bits (319), Expect = 5e-27
Identities = 52/104 (50%), Positives = 82/104 (78%)
Frame = +1
Query: 8194 GLDRSRFDNRSVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDW 8373
GL+R +FDN++VTFE H + EHN+WHYL++IV++++KD TE+TGPESYVA+ +K+ NLDW
Sbjct: 2202 GLERDKFDNKTVTFEEHIKEEHNMWHYLFFIVLVKVKDSTEYTGPESYVAEMIKEHNLDW 2261
Query: 8374 FPRMQALSLQDSELDTDQSEVKQMKDQLLQMMTLMREIISQNEE 8505
FPRM+A+SL S+ + +Q+E++ ++++L M L+ + Q E
Sbjct: 2262 FPRMRAMSLVSSDAEGEQNEIRNLQEKLESTMRLVANLSGQLSE 2305
Score = 63.9 bits (154), Expect = 6e-08
Identities = 32/50 (64%), Positives = 37/50 (74%)
Frame = +1
Query: 109 LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFR 258
LHIGDI SLY E S+N GF+STLGLVDDRC+V+ G +PPKKFR
Sbjct: 9 LHIGDICSLYAEGSTN----GFISTLGLVDDRCVVQPDAGDLNNPPKKFR 54
>gi|19388011|gb|AAH25805.1| Itpr5 protein [Mus musculus]
Length = 1412
Score = 837 bits (2161), Expect = 0.0
Identities = 532/1491 (35%), Positives = 788/1491 (52%), Gaps = 29/1491 (1%)
Frame = +1
Query: 4141 EELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDN 4320
E ++ H V IE + R+ +L LQ +V K ++ Q+ V E+ ++V Y D
Sbjct: 1 ERVVQHFVHCIETHGRHVEYLRFLQTIVKADGKYVKKCQDMVMTELINGGEDVLIFYNDR 60
Query: 4321 ASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDH 4500
ASF L MM E+ D L YHI LV LLA CT GKN TE+KC S +P+D
Sbjct: 61 ASFPILLNMMCSERAR----GDESGPLAYHITLVELLAACTEGKNVYTEIKCNSLLPLDD 116
Query: 4501 IVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEK 4680
IVRVVT C+ EVK Y+ + HCY+DT+ EMK+ Y + ++ + N L D+ +
Sbjct: 117 IVRVVTHDDCIPEVKIAYVNFVNHCYVDTEVEMKEIYTSNHIWKLFENFLVDMARVCNTT 176
Query: 4681 LTGAETAT-LEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKG 4857
T LE + +V ++ FF +P+S + H+ F ++L +
Sbjct: 177 TDRKHADTFLERCVTESVMNIVSGFFNSPFS---DNSTSLQTHQPVFIQLLQSAFRIYNC 233
Query: 4858 KLRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKW 5037
+ V CI+ L + A+ I +P L S ++ K +S+ +
Sbjct: 234 TWPNPAQKAS---VESCIRALAEVAKNRGIAIPVDLD----SQVNTLFMK--NHSSTVQR 284
Query: 5038 IGIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVL 5217
+G RL+ ++ L G + N++ ++ + P+ AE SVL
Sbjct: 285 AAMGWRLSARSGPRFKEALGGPAWDYR-----NIIEKLQDVVASLEQQFSPMMQAEFSVL 339
Query: 5218 VEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCT 5397
V+VL++PELLFPEGS R +C G ++KLI H K LM+ K++ LC ++LQTL +M +
Sbjct: 340 VDVLYSPELLFPEGSDARIRC--GAFMSKLINHTKKLME-KEEKLCIKILQTLREMLE-K 395
Query: 5398 KXXXXXXXXXXXXXXXXRYFGHHNNHHPPLDRQQSXXXXXXXXXXXXXXXTWSQERDLYA 5577
K RYF +H ++ S S + +
Sbjct: 396 KDSFMEEGSTLRRILLNRYF--KGDHSVSVNGPLSGAYAKTAQVGGGFSGQDSDKTGISM 453
Query: 5578 --IQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDI 5751
IQC L+ GAS+LV D+I+ + IF + I L ALL GN + Q+SFY ++ ++
Sbjct: 454 SDIQCLLDKEGASELVIDVIVNTKNDRIFSEGILLGIALLEGGNTQTQYSFYQQLHEQKK 513
Query: 5752 HEPFFKAILTRIQTAQNRLKSDMMSCSDSKPKVSLSATVSRRSSTVLT--PLIDAGDT-- 5919
E FFK + R++ AQ ++S + + + L + S V+ P + D+
Sbjct: 514 SEKFFKVLYDRMKAAQKEIRSTV-----TVNTIDLGSKKREEDSDVMALGPRMRVRDSSL 568
Query: 5920 ----GFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTD--ALPPEVAL 6081
G G L E ++ ++ P EEKS + + P + +
Sbjct: 569 HLREGMKGQLTEASSATSKAYCVYRREMDPEIDTMCPGQEAGSAEEKSAEEVTMSPAITI 628
Query: 6082 VEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFG-EI 6258
+ PILR LQLLCENHN LQNFLR Q+++TN+NLV ETL FLD +CGST G LG+ G I
Sbjct: 629 MRPILRFLQLLCENHNRELQNFLRNQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYI 688
Query: 6259 GEHNFSLITQTLATLTEFCQGPCHENQNTMAMQE-NGLNIIISLVLNEIKPLADDHMELA 6435
E N +L+ QTL +LTE+CQGPCHENQ +A E NG++III+L+LN+I PL M+L
Sbjct: 689 NERNVALVNQTLESLTEYCQGPCHENQTCIATHESNGIDIIIALILNDINPLGKYRMDLV 748
Query: 6436 LEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLK 6615
L++K+ AS K L+ ++ ++ N+ +
Sbjct: 749 LQLKNNAS------------------------------KLLLAIMESRHDSENAERILFN 778
Query: 6616 SISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDD 6795
R+L D+ K + Q G+ H D++ DD
Sbjct: 779 MRPRELV-----DVMKNAYNQ----------------GLECDHG--------DEEGGDD- 808
Query: 6796 IPSVDPREVGHNIYILAHQLAIHDGELEIWLD-GSDEKKDDLTREALNYYKERTAQIEIV 6972
V P++VGHNIYILAHQLA H+ L+ L GSD ++ D EAL YY TAQIEIV
Sbjct: 809 --GVSPKDVGHNIYILAHQLARHNKLLQQMLKPGSDPEEGD---EALKYYANHTAQIEIV 863
Query: 6973 RRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRK 7152
R DRT+E++VFP+ +IC +LT+++K V+N TERD QGSKV +FF + E +Y+EM WQ+K
Sbjct: 864 RHDRTMEQIVFPVPNICEFLTRESKYRVFNTTERDEQGSKVNDFFQQTEDLYNEMKWQKK 923
Query: 7153 LQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYS---WFAV 7323
+++ L W + LW +SF+ A +N VA +YP + + +L ++S W AV
Sbjct: 924 IRNNPALFWFPRHISLWGSISFNLAVFINLAVALFYPFGDDGDEG-TLSPMFSALLWVAV 982
Query: 7324 -FSSFLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVA 7500
+ +L + + I IG+ TL + G L NKIV +V+
Sbjct: 983 AICTSMLFFFSKPVGI------RPFLVSVMLRSIYTIGLGPTLILLGAANLCNKIVFLVS 1036
Query: 7501 FVSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVI 7680
FV N+G R ++ Y + Y+ +C+LGL VH Y LLFD+++ EETL NVI
Sbjct: 1037 FVGNRGTFTRGYRAVILDMAFLYHVAYVLVCMLGLFVHEFFYSFLLFDLVYREETLLNVI 1096
Query: 7681 ASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPS--- 7851
SVTRN +SI+ T +LALIL+Y FSI+GFL+ + DF +EVD ++N + T + G+P+
Sbjct: 1097 KSVTRNGRSIILTAVLALILVYLFSIIGFLFLKDDFTMEVDRLKNRTPVTGNHGVPTMTL 1156
Query: 7852 ----ETCPSEGCPGLQPSXXXXXXXXXXXX--SCETLWMCILQTGYQGLRNGGGIGDVLR 8013
ETC E C PS +C+TL MCI+ QGLRNGGG+GDVLR
Sbjct: 1157 SSMMETCQKENCSPTIPSSNTAGEEGEDGIERTCDTLLMCIVTVLNQGLRNGGGVGDVLR 1216
Query: 8014 NPAPWEDMFIWRVAYDMTXXXXXXXXXXXXXXXXXXDTFGDLRAEKNEKEQILKNNCFIC 8193
P+ E +F RV YD+ DTF DLR+EK +KE+ILK CFIC
Sbjct: 1217 RPSKDEPLFAARVVYDLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFIC 1276
Query: 8194 GLDRSRFDNRSVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDW 8373
GL+R +FDN++V+FE H ++EHN+WHYLY+IV++++KD TE+TGPESYVAQ + ++NLDW
Sbjct: 1277 GLERDKFDNKTVSFEEHIKSEHNMWHYLYFIVLVKVKDPTEYTGPESYVAQMITEKNLDW 1336
Query: 8374 FPRMQALSLQDSELDTDQSEVKQMKDQLLQMMTLMREIISQNEESRAFMEQ 8526
FPRM+A+SL +E D++Q+E++ ++++L M+L++++ Q E + M +
Sbjct: 1337 FPRMRAMSLVSNEGDSEQNEIRNLQEKLESTMSLVKQLSGQLAELKEQMTE 1387
>gi|47227347|emb|CAF96896.1| unnamed protein product [Tetraodon
nigroviridis]
Length = 2743
Score = 747 bits (1929), Expect = 0.0
Identities = 486/1232 (39%), Positives = 684/1232 (55%), Gaps = 99/1232 (8%)
Frame = +1
Query: 109 LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
LHIGDI SLY E ++ GF+STLGLVDDRC+V+ G +PPKKFRDCLF++CP+N
Sbjct: 9 LHIGDICSLYAEGTTC----GFISTLGLVDDRCVVQPDTGDLNNPPKKFRDCLFRLCPMN 64
Query: 289 RYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQ 468
RY+AQK W K G+S D L+NKL AAD E+++NESE +K LG VIQYG+++Q
Sbjct: 65 RYSAQKQFWKAAK--PGGNSTTDAVLLNKLHHAADLEKKQNESENRKLLGTVIQYGNVIQ 122
Query: 469 LLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKI 648
LLH+KSNKY+TV K PA E+NAM+V LD AGNEGSWF I+P YK ++GD+V G+K+
Sbjct: 123 LLHLKSNKYLTVNKRLPALLEKNAMRVTLDSAGNEGSWFYIQPFYKLRSLGDSVVIGDKV 182
Query: 649 SLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSV 828
L P AG LH SS L+D+ EVN +N T W+V +F+ + +N++ +
Sbjct: 183 VLNP-----VNAGQ---PLHASSHQLVDNPGCNEVNSVNCNTSWKVVLFMKWSDNKETIL 234
Query: 829 KSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTN 1008
K GDVVRLFHA+Q+ FLT D K+ VFLR T R SA ATSS+ALWEV+VV +
Sbjct: 235 KGGDVVRLFHAEQEKFLTCDDHRKKQ----YVFLRTTGRQSATSATSSKALWEVEVVHHD 290
Query: 1009 AYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRRASLIYSKTNNPMAMYSDGP 1188
RGG WN +RFKHLAT YL+AE +V P D
Sbjct: 291 PCRGGAGYWNSLFRFKHLATGCYLAAEVGEVV----------------DFTPFNFQLDAD 334
Query: 1189 NGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLL 1368
N Q+ + ++ L P D + +F+LDP+T + VPR SYVRL
Sbjct: 335 NEALRGRLRAPQEKV--MYTLVPVPDGM---DISSIFELDPTTLRGGDSMVPRNSYVRLR 389
Query: 1369 HQSSDKWVHATNATEKQNLHYSSKNEKGWVKVI-CEKNRVDKETFALLPVNPDEVRDLDF 1545
H ++ WVH+T L + EK + +I + DKE FA++PV P EVRDLDF
Sbjct: 390 HLCTNTWVHSTV------LPIDKEEEKPVMLMIGTSAVKEDKEAFAIVPVPPAEVRDLDF 443
Query: 1546 ANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPSR 1725
ANDA K L + ++ G + E T+LL D + FV + + D L+I PSR
Sbjct: 444 ANDASKVLASIAGKLEKGTITQNER-RFVTKLLEDLVFFVVDIPNSGQDVLEIMVNKPSR 502
Query: 1726 DRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIFKTMFQLCYCL 1905
+RQKL+REQ +L Q+F LL+APF T D R+ F+ + +LCY +
Sbjct: 503 ERQKLMREQNILKQIFKLLQAPF-----TDSGDGPMLRLEELGDQRHAPFRHICRLCYRV 557
Query: 1906 LKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFV 2085
L++SQ YRKNQ A++F +Q+QIG+D++AEDT+TA+LHNN KLLEK++ ++ FV
Sbjct: 558 LRHSQQDYRKNQA--AKQFRFMQKQIGYDVLAEDTITALLHNNRKLLEKHITAAEIDTFV 615
Query: 2086 ELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGW 2265
LVR NR+ +FLDYL+DLCV ++ QELIC +VL + DI ++TK++ E+
Sbjct: 616 TLVRKNREPRFLDYLSDLCVSMQKSIPVTQELICNAVLDPSNADILIETKLVLSRFEIET 675
Query: 2266 APN-------------------------FRKLVDIAEGAK-SNSDDAEHLDYYRHQLDLL 2367
A N + + ++A+ AK +D E + YYR QL+L
Sbjct: 676 ASNGESPVEAEDEEEVWLFWKDNCKEIRSKSIRELAQDAKEGQKEDLEVVSYYRCQLNLF 735
Query: 2368 SQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLHLHVVR 2547
++MC ++QYLAI+ IS QL +L+L+CMSD LP+DLR SF RLMLH+HV R
Sbjct: 736 ARMCLDRQYLAIN--------KISGQLDVDLILRCMSDEDLPFDLRASFCRLMLHMHVDR 787
Query: 2548 G--SPMSAIRHARLWWSIPENVNV-STYESVSVEAYSDG-SRMRIGEGIAHKVLATVETY 2715
++ +++ARLW IP + + +Y+ +DG +R I E + + VETY
Sbjct: 788 DPQEQVTPVKYARLWSEIPSKIAIDDSYD-------NDGTTRDEIKERFS-LTMDFVETY 839
Query: 2716 LMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAI-------- 2871
L + +Q++ +KLT+E+VNLA+ L F FY+F+DLL+LT+ LL I
Sbjct: 840 LREVVSQNVPFSDK-EKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKVLLNILDCVHVST 898
Query: 2872 ---INEGPATEQVPSHRAM--VNAIRN-MSKSMMRGGNKENSKDLAKTPSVTAEEAGRTK 3033
IN+ E+ M ++ + M++ ++RGG + + + +
Sbjct: 899 IYPINKMEKEEENKGSNVMKSIHGVGELMTQVVLRGGGLLPTTPTHQPQGDVVKTQTEPE 958
Query: 3034 EGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDE-----DGS-------- 3174
+ + TKL + EILQF+++VR DYRI+ L FK+ F DE DG+
Sbjct: 959 REDIMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKHEF--DESNPQADGAAAQNGTNN 1016
Query: 3175 ---------------------------------------LMHSASINERMASELYDAIYR 3237
L+ +++ E + I+
Sbjct: 1017 VTSQMPGTMDRFDSRQSFNTVGEAMLIRCNFLLNLKKTLLISVGNLDFEKIEEQAEGIFG 1076
Query: 3238 SSGHELHLDGRD--GQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQL 3411
S LD D G+ L +LL +TM DYPPL S AL + FRHF+Q QE+L KQVQL
Sbjct: 1077 GSEENSPLDLDDHGGRTFLRVLLHLTMHDYPPLVSGALHLLFRHFSQRQEVLMAFKQVQL 1136
Query: 3412 LVSNNDVENYRQIDRDLFILKNLTEKSELWVH 3507
LV++ DV+NY+QI DL L+++ EKSELWV+
Sbjct: 1137 LVTSQDVDNYKQIKSDLDQLRSIVEKSELWVY 1168
Score = 707 bits (1824), Expect = 0.0
Identities = 469/1322 (35%), Positives = 691/1322 (51%), Gaps = 27/1322 (2%)
Frame = +1
Query: 3931 DHDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFR 4110
D M ++ L+HEFL++FC N++NQ L+K ++ + G+L T++ IF
Sbjct: 1214 DIRMQDIMKLAHEFLQNFCAGNQQNQVLLHKHVNLFLNP--GILEATTMQH------IFM 1265
Query: 4111 NNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAAS 4290
NN +L S + E ++ H V E + R+ +L+ LQ +V +K I+ Q+ V E+ +
Sbjct: 1266 NNFQLCSEINERVVQHFVHCTETHGRHVQYLKFLQTIVKAENKSIKKCQDIVMAEMVNSG 1325
Query: 4291 DEVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTEL 4470
++V Y D ASF+ L MM+ E++ D L YHI LV LLA+CT GKN TE+
Sbjct: 1326 EDVLVFYNDRASFQTLIQMMRSERDRM----DENSPLLYHIHLVELLAVCTEGKNVYTEI 1381
Query: 4471 KCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLL 4650
KC S +P+D IVRVVT + C+ EVK Y+ L HCY+DT+ EMK+ Y + ++ + N L
Sbjct: 1382 KCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCYVDTEVEMKEIYTSNHMWKLFENFL 1441
Query: 4651 EDIRSL--RVEKLTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSE 4824
DI + A+T TLE Y+ TV ++ FF +P+S D +T
Sbjct: 1442 VDICRVCNNTSDRKHADT-TLERYVTETVMSIVTCFFSSPFS-------DQSTSLQTRQP 1493
Query: 4825 VLLELTYLEKGKLRGSKSSRNWYR------VAECIKRLTKWAEEHNITLPATLAGPQMSG 4986
V ++L +G R NW V CIK L+ A+ I +P L
Sbjct: 1494 VFVQLL---QGVFRVYHC--NWLNPVQKASVEACIKVLSDVAKSRAIAIPVDL------- 1541
Query: 4987 QTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIG 5166
+ V + ++ + + + RL+ +NT S+ T N++ ++
Sbjct: 1542 DSQVNNLFVKSNNVVQKSILSWRLSAKNTSRRD------SSLTTSKDYRNIIERLQDIVS 1595
Query: 5167 EFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQD 5346
+ L PL AE SVLV+VLH PELLFPE + R +C GG ++KLI+H K L++ ++
Sbjct: 1596 ALEDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKCESGGFISKLIKHTKQLLEENEE 1655
Query: 5347 NLCARVLQTLCKMCDCTKXXXXXXXXXXXXXXXXRYFGHHNNHHPPLDRQQSXXXXXXXX 5526
LC +VLQTL +M + RY+G+ ++ R++S
Sbjct: 1656 RLCIKVLQTLREMMTKDRGYGEKGEALRHILVN-RYYGNVKSNQ----RRESLATFSNGP 1710
Query: 5527 XX----------XXXXXTWSQERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHL 5676
E L +QC L+ GASDLV D+I+ S IF ++I L
Sbjct: 1711 VTPGVQGKVPAVVSSGIGGRGELSLAEVQCHLDKEGASDLVIDLIMNATSDRIFQESILL 1770
Query: 5677 ARALLHEGNDKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRLKSDM-MSCSD--SKPK 5847
A ALL GN +Q SF+ R+ + E FF+ R++ AQ +K+ M ++ SD SK K
Sbjct: 1771 AIALLEGGNPVIQRSFFHRLTGDNKSERFFRVFNDRMKLAQQEIKATMTVNTSDLGSKKK 1830
Query: 5848 VSLSATVSRRSSTVLTPLIDAGDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLA 6027
A P++ L E + + ++ + + +
Sbjct: 1831 DEEPADKDAPGRVKDVPVVAVVTEEAKEQLAEASTVTKKAFATYRREMEAEEHQAAAEGT 1890
Query: 6028 PYQDEEKSTD--ALPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLS 6201
P +K + + + +++PILR+LQLLCENHN LQNFLR Q+++ N+NLV ETL
Sbjct: 1891 PVPTADKGQEDGEMSVIITIMQPILRLLQLLCENHNRDLQNFLRNQNNKNNYNLVCETLQ 1950
Query: 6202 FLDTVCGSTKGSLGVFG-EIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQE-NGLNI 6375
FLD +CGST G LG+ G I E N LI QT+ +LTE+CQGPCHENQN +A E NG++I
Sbjct: 1951 FLDCICGSTTGGLGLLGLYINEKNVGLINQTVESLTEYCQGPCHENQNCIATHECNGIDI 2010
Query: 6376 IISLVLNEIKPLADDHMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQ 6555
II+L+LN+I PL M+L LE+K+ ASKLLLAIMESRHD E A R+L NM PK+
Sbjct: 2011 IIALILNDINPLGKKRMDLVLELKNNASKLLLAIMESRHDSETAERILYNMR-----PKE 2065
Query: 6556 LVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIV 6735
LV IK+A + Q E ++++ PE +
Sbjct: 2066 LVEVIKKA------------------YMQGEIEVEE-------------PEEGEEG---- 2090
Query: 6736 SIHTEKNISSSLDDKFNDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLD-GSDEKKD 6912
++ S PR VGHNIYILAHQLA H+ EL+ L G +
Sbjct: 2091 ------------------EEEHSASPRNVGHNIYILAHQLARHNKELQAMLKPGGTYGEG 2132
Query: 6913 DLTREALNYYKERTAQIEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSK 7092
D EAL +Y + TAQIEIVR DRT+E++VFP+ +IC +LT+++K VY TERD QGSK
Sbjct: 2133 D---EALEFYAKHTAQIEIVRLDRTMEQIVFPVPNICEFLTQESKLRVYYTTERDEQGSK 2189
Query: 7093 VTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPE 7272
+ +FF E +++EM WQ+KL+ + L WC+ + W+ +SF+ A ++N LVA +YPL
Sbjct: 2190 INDFFLRSEDLFNEMNWQKKLRAQPILYWCSRNMSFWSSISFNLAVLMNLLVAFFYPLEA 2249
Query: 7273 HSNSSISLG-NLYSWFAVFSSFLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTL 7449
++ + W A+ S + L +G+ TL
Sbjct: 2250 VRGGTLEPHLSALLWMAMLVSLAIVIVLPQP-----HGIRALIASTILRLIFSVGLEPTL 2304
Query: 7450 YIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYC 7629
++ G L NK++ +++FV N+G R ++ Y L+YL IC LG+ +H Y
Sbjct: 2305 FLLGAFNLCNKVIFLMSFVGNRGTFTRGYKAMITDVEFLYHLLYLIICCLGVFLHVFFYS 2364
Query: 7630 ILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPV 7809
+LLFD+++ EETL NVI SVTRN +SIV T +LALIL+Y FSI+G+++F+ DF L VD +
Sbjct: 2365 LLLFDLVYREETLLNVIKSVTRNGRSIVLTAVLALILVYLFSIVGYIFFKDDFILAVDRI 2424
Query: 7810 EN 7815
N
Sbjct: 2425 PN 2426
Score = 206 bits (525), Expect = 6e-51
Identities = 93/199 (46%), Positives = 138/199 (68%)
Frame = +1
Query: 7930 SCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTXXXXXXXXXXXXXX 8109
+C++L MCI+ GLR+GGG+GDVLR P+ E +F RV YD+
Sbjct: 2520 TCDSLLMCIVTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVIYDLLFFFMVIIIVLNLIF 2579
Query: 8110 XXXXDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLYYIV 8289
DTF DLR+EK +KE+ILK CFICGL+R +FDN++VTFE H + EHN+WHYL++IV
Sbjct: 2580 GVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVTFEEHIKVEHNMWHYLFFIV 2639
Query: 8290 MLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLLQMM 8469
++++KD TE+TGPESYVA+ ++++NLDWFPRM+A+SL S+ D +Q+E++ ++++L M
Sbjct: 2640 LVKVKDSTEYTGPESYVAEMIREQNLDWFPRMRAMSLVSSDADGEQNEIRSLQEKLESTM 2699
Query: 8470 TLMREIISQNEESRAFMEQ 8526
L+ + Q E + M +
Sbjct: 2700 KLVSNLSGQLTELKEQMTE 2718
Score = 49.7 bits (117), Expect = 0.001
Identities = 63/301 (20%), Positives = 119/301 (38%), Gaps = 48/301 (15%)
Frame = +1
Query: 3838 KPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLS---HEFLRSFCKT----- 3993
KP Q+L++ + + + + + P D M++L L H R C+
Sbjct: 499 KPSRERQKLMREQNILKQIFKLLQAPFTDSGDGPMLRLEELGDQRHAPFRHICRLCYRVL 558
Query: 3994 -------NKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELAS-NVPEEL 4149
K ++ ++F+ +K +L +TI A+ NNR+L ++
Sbjct: 559 RHSQQDYRKNQAAKQFRFM--QKQIGYDVLAEDTI------TALLHNNRKLLEKHITAAE 610
Query: 4150 IAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDE---------VR 4302
I V L+ N R P FL+ L L K I QE + N + S+ +
Sbjct: 611 IDTFVTLVRKN-REPRFLDYLSDLCVSMQKSIPVTQELICNAVLDPSNADILIETKLVLS 669
Query: 4303 QLYVDNASFEELEAMMKDE-----------KESKGRS-----SDSRRKLKYHIELV---- 4422
+ ++ AS E +DE KE + +S D++ K +E+V
Sbjct: 670 RFEIETASNGESPVEAEDEEEVWLFWKDNCKEIRSKSIRELAQDAKEGQKEDLEVVSYYR 729
Query: 4423 ---RLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDA 4593
L A + K + Q+ +D I+R ++ + +++ + +L+LH ++D D
Sbjct: 730 CQLNLFARMCLDRQYLAINKISGQLDVDLILRCMSDEDLPFDLRASFCRLMLHMHVDRDP 789
Query: 4594 E 4596
+
Sbjct: 790 Q 790
>gi|21362620|sp||Q9Z329_2 [Segment 2 of 2] Inositol
1,4,5-trisphosphate receptor type 2 (Type 2 inositol
1,4,5-trisphosphate receptor) (Type 2 InsP3 receptor)
(IP3 receptor isoform 2) (InsP3R2) (Inositol
1,4,5-trisphosphate type V receptor)
gi|1495696|emb|CAA94861.1| inositol 1,4,5-trisphosphate receptor type
2 [Mus musculus]
Length = 1009
Score = 666 bits (1718), Expect = 0.0
Identities = 391/1009 (38%), Positives = 570/1009 (55%), Gaps = 26/1009 (2%)
Frame = +1
Query: 5578 IQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHE 5757
IQC L+ GAS+LV D+I+ + IF + I L ALL GN + Q+SFY ++ ++ E
Sbjct: 53 IQCLLDKEGASELVIDVIVNTKNDRIFSEGILLGIALLEGGNTQTQYSFYQQLHEQKKSE 112
Query: 5758 PFFKAILTRIQTAQNRLKSDMMSCSDSKPKVSLSATVSRRSSTVLT--PLIDAGDT---- 5919
FFK + R++ AQ ++S + + + L + S V+ P + D+
Sbjct: 113 KFFKVLYDRMKAAQKEIRSTV-----TVNTIDLGSKKREEDSDVMALGPRMRVRDSSLHL 167
Query: 5920 --GFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTD--ALPPEVALVE 6087
G G L E ++ ++ P EEKS + + P + ++
Sbjct: 168 REGMKGQLTEASSATSKAYCVYRREMDPEIDTMCPGQEAGSAEEKSAEEVTMSPAITIMR 227
Query: 6088 PILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFG-EIGE 6264
PILR LQLLCENHN LQNFLR Q+++TN+NLV ETL FLD +CGST G LG+ G I E
Sbjct: 228 PILRFLQLLCENHNRELQNFLRNQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINE 287
Query: 6265 HNFSLITQTLATLTEFCQGPCHENQNTMAMQE-NGLNIIISLVLNEIKPLADDHMELALE 6441
N +L+ QTL +LTE+CQGPCHENQ +A E NG++III+L+LN+I PL M+L L+
Sbjct: 288 RNVALVNQTLESLTEYCQGPCHENQTCIATHESNGIDIIIALILNDINPLGKYRMDLVLQ 347
Query: 6442 IKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSI 6621
+K+ AS K L+ ++ ++ N+ +
Sbjct: 348 LKNNAS------------------------------KLLLAIMESRHDSENAERILFNMR 377
Query: 6622 SRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIP 6801
R+L D+ K + Q G+ H D++ DD
Sbjct: 378 PRELV-----DVMKNAYNQ----------------GLECDHG--------DEEGGDD--- 405
Query: 6802 SVDPREVGHNIYILAHQLAIHDGELEIWLD-GSDEKKDDLTREALNYYKERTAQIEIVRR 6978
V P++VGHNIYILAHQLA H+ L+ L GSD ++ D EAL YY TAQIEIVR
Sbjct: 406 GVSPKDVGHNIYILAHQLARHNKLLQQMLKPGSDPEEGD---EALKYYANHTAQIEIVRH 462
Query: 6979 DRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQ 7158
DRT+E++VFP+ +IC +LT+++K V+N TERD QGSKV + F + E +Y+EM WQ+K++
Sbjct: 463 DRTMEQIVFPVPNICEFLTRESKYRVFNTTERDEQGSKVNDLFQQTEDLYNEMKWQKKIR 522
Query: 7159 DRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYS---WFAV-F 7326
+ L W + + LW +SF+ A +N VA +YP + + +L ++S W AV
Sbjct: 523 NNPALFWFSRHISLWGSISFNLAVFINLAVALFYPFGDDGDEG-TLSPMFSALLWVAVAI 581
Query: 7327 SSFLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVAFV 7506
+ +L + + I IG+ TL + G L NKIV +V+FV
Sbjct: 582 CTSMLFFFSKPVGI------RPFLVSVMLRSIYTIGLGPTLILLGAANLCNKIVFLVSFV 635
Query: 7507 SNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIAS 7686
N+G R ++ Y + Y+ +C+LGL VH Y LLFD+++ EETL NVI S
Sbjct: 636 GNRGTFTRGYRAVILDMAFLYHVAYVLVCMLGLFVHEFFYSFLLFDLVYREETLLNVIKS 695
Query: 7687 VTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPS----- 7851
VTRN +SI+ T +LALIL+Y FSI+GFL+ + DF +EVD ++N + T + G+P+
Sbjct: 696 VTRNGRSIILTAVLALILVYLFSIIGFLFLKDDFTMEVDRLKNRTPVTGNHGVPTMTLSS 755
Query: 7852 --ETCPSEGCPGLQPSXXXXXXXXXXXX--SCETLWMCILQTGYQGLRNGGGIGDVLRNP 8019
ETC E C PS +C+TL MCI+ QGLRNGGG+GDVLR P
Sbjct: 756 MMETCQKENCSPTIPSSNTAGEEGEDGIERTCDTLLMCIVTVLNQGLRNGGGVGDVLRRP 815
Query: 8020 APWEDMFIWRVAYDMTXXXXXXXXXXXXXXXXXXDTFGDLRAEKNEKEQILKNNCFICGL 8199
+ E +F RV YD+ DTF DLR+EK +KE+ILK CFICGL
Sbjct: 816 SKDEPLFAARVVYDLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGL 875
Query: 8200 DRSRFDNRSVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFP 8379
+R +FDN++V+FE H ++EHN+WHYLY+IV++++KD TE+TGPESYVAQ + ++NLDWFP
Sbjct: 876 ERDKFDNKTVSFEEHIKSEHNMWHYLYFIVLVKVKDPTEYTGPESYVAQMITEKNLDWFP 935
Query: 8380 RMQALSLQDSELDTDQSEVKQMKDQLLQMMTLMREIISQNEESRAFMEQ 8526
RM+A+SL +E D++Q+E++ ++++L M+L++++ Q E + M +
Sbjct: 936 RMRAMSLVSNEGDSEQNEIRNLQEKLESTMSLVKQLSGQLAELKEQMTE 984
>gi|26339686|dbj|BAC33514.1| unnamed protein product [Mus musculus]
Length = 1004
Score = 658 bits (1697), Expect = 0.0
Identities = 413/1017 (40%), Positives = 591/1017 (57%), Gaps = 45/1017 (4%)
Frame = +1
Query: 259 DCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLG 438
DCLFK+CP+NRY+AQK W K +S D L+NKL AAD E+++NE+E +K LG
Sbjct: 5 DCLFKLCPMNRYSAQKQFWKAAK--PGANSTTDAVLLNKLHHAADLEKKQNETENRKLLG 62
Query: 439 NVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAI 618
VIQYG+++QLLH+KSNKY+TV K PA E+NAM+V LD AGNEGSWF I+P YK +I
Sbjct: 63 TVIQYGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSI 122
Query: 619 GDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFL 798
GD+V G+K+ L P AG LH SS L+D+ EVN +N T W++ +F+
Sbjct: 123 GDSVVIGDKVVLNP-----VNAG---QPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFM 174
Query: 799 LFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRA 978
+ +N+ + +K GDVVRLFHA+Q+ FLT D K+ VFLR T R SA ATSS+A
Sbjct: 175 KWSDNKDDILKGGDVVRLFHAEQEKFLTCDEHRKKQH----VFLRTTGRQSATSATSSKA 230
Query: 979 LWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRRASLIYSKTN 1158
LWEV+VVQ + RGG WN +RFKHLAT YL+AE V P + L + +
Sbjct: 231 LWEVEVVQHDPCRGGAGYWNSLFRFKHLATGHYLAAE-----VDP--DFEEECLEFQPSV 283
Query: 1159 NPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPE-EDANLLFQLDPSTFMKSNK 1335
+P D + + ++ SV PE D + +F+LDP+T +
Sbjct: 284 DP---DQDASRSRLRNAQEKMVYSLVSV----------PEGNDISSIFELDPTTLRGGDS 330
Query: 1336 EVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKG-WVKVICEKNRVDKETFALLP 1512
VPR SYVRL H ++ WVH+T N+ + EK +K+ + DKE FA++P
Sbjct: 331 LVPRNSYVRLRHLCTNTWVHST------NIPIDKEEEKPVMLKIGTSPLKEDKEAFAIVP 384
Query: 1513 VNPDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLAD 1692
V+P EVRDLDFANDA K L + ++ G + E S T+LL D + FVT ++ D
Sbjct: 385 VSPAEVRDLDFANDASKVLGSIAGKLEKGTITQNER-RSVTKLLEDLVYFVTGGTNSGQD 443
Query: 1693 PLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEI 1872
L++ P+R+RQKL+REQ +L Q+F LL+APF T D R+
Sbjct: 444 VLEVVFSKPNRERQKLMREQNILKQIFKLLQAPF-----TDCGDGPMLRLEELGDQRHAP 498
Query: 1873 FKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEK 2052
F+ + +LCY +L++SQ YRKNQE++A++FG +Q+QIG+D++AEDT+TA+LHNN KLLEK
Sbjct: 499 FRHICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEK 558
Query: 2053 YVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDT 2232
++ ++ FV LVR NR+ +FLDYL+DLCV ++ QELIC +VL+ + DI ++T
Sbjct: 559 HITAAEIDTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIET 618
Query: 2233 KII---------------------DGEIEVGWAPNFRKL-----VDIAEGAK-SNSDDAE 2331
K++ + E+ + W + +++ ++A+ AK +D +
Sbjct: 619 KLVLSRFEFEGVSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDAKEGQKEDRD 678
Query: 2332 HLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGS 2511
L YYR+QL+L ++MC ++QYLAI+ IS QL +L+L+CMSD LPYDLR S
Sbjct: 679 ILSYYRYQLNLFARMCLDRQYLAIN--------EISGQLDVDLILRCMSDENLPYDLRAS 730
Query: 2512 FTRLMLHLHVVRG--SPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIA 2685
F RLMLH+HV R ++ +++ARLW IP + + Y+S S S+ I E A
Sbjct: 731 FCRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDS------SGTSKDEIKERFA 784
Query: 2686 HKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLL 2865
+ + VE YL + Q +KLT+E+VNLA+ L F FY+F+DLL+LT+ LL
Sbjct: 785 -QTMEFVEEYLRDVVCQRFPFSDK-EKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILL 842
Query: 2866 AIINEGPATEQVPSHRAM-------VNAIRN-------MSKSMMRGGNKENSKDLAKTPS 3003
AI++ T P + N +R+ M++ ++RGG +A P
Sbjct: 843 AILDCVHVTTIFPISKMTKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPE 902
Query: 3004 VTAEEAGRTKEGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGS 3174
++A KE + + TKL + EILQF+++VR DYRI+ L FK F DE S
Sbjct: 903 GNVKQAEPEKED-IMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREF--DESNS 956