BLASTX 2.2.4 [Aug-26-2002]
Query= F33D4_4
         (8574 letters)

Database: /home/niguts/usr02/tshini/ykclst/db/nr.seq
           1,967,186 sequences; 661,712,633 total letters


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|17541126|ref|NP_501253.1| inositol 1 4 5-Triphosphate Recepto...  5546   0.0
gi|7500399|pir||T32550 hypothetical protein F33D4.2a - Caenorhab...  5508   0.0
gi|17541128|ref|NP_501252.1| inositol 1 4 5-Triphosphate Recepto...  5472   0.0
gi|14574164|gb|AAK68362.1| Inositol triphosphate receptor protei...  5472   0.0
gi|14574166|gb|AAK68364.1| Inositol triphosphate receptor protei...  5469   0.0
gi|25153695|ref|NP_501250.2| inositol 1 4 5-Triphosphate Recepto...  5445   0.0
gi|25153698|ref|NP_501251.2| inositol 1 4 5-Triphosphate Recepto...  5442   0.0
gi|10636263|emb|CAC10528.1| putative inositol 1,4,5-trisphosphat...  4970   0.0
gi|39593648|emb|CAE61940.1| Hypothetical protein CBG05938 [Caeno...  4953   0.0
gi|7500401|pir||T32552 hypothetical protein F33D4.2c - Caenorhab...  3794   0.0
gi|14574165|gb|AAK68363.1| Inositol triphosphate receptor protei...  3623   0.0
gi|22532932|gb|AAM98028.1| Inositol triphosphate receptor protei...  3308   0.0
gi|46107962|gb|AAB04947.2| inositol 1,4,5-trisphosphate receptor...  1654   0.0
gi|10835023|ref|NP_002213.1| inositol 1,4,5-triphosphate recepto...  1651   0.0
gi|34857738|ref|XP_342733.1| similar to Inositol 1,4,5-trisphosp...  1644   0.0
gi|6754390|ref|NP_034715.1| inositol 1,4,5-triphosphate receptor...  1642   0.0
gi|17380349|sp|P29994|IP3R_RAT Inositol 1,4,5-trisphosphate rece...  1640   0.0
gi|1362832|pir||A55713 inositol 1,4,5-triphosphate receptor type...  1639   0.0
gi|7522013|pir||T31431 inositol 1,4,5-trisphosphate receptor, lo...  1634   0.0
gi|4504793|ref|NP_002214.1| inositol 1,4,5-triphosphate receptor...  1627   0.0
gi|27805961|ref|NP_776794.1| inositol 1,4,5-triphosphate recepto...  1624   0.0
gi|13022060|gb|AAK11622.1| IP3 receptor isoform 2 [Rattus norveg...  1621   0.0
gi|18307586|dbj|BAB84088.1| inositol 1,4,5-trisphosphate recepto...  1617   0.0
gi|13591975|ref|NP_112308.1| inositol 1,4,5-triphosphate recepto...  1616   0.0
gi|27807313|ref|NP_777266.1| inositol 1,4,5-triphosphate recepto...  1612   0.0
gi|4504795|ref|NP_002215.1| inositol 1,4,5-triphosphate receptor...  1582   0.0
gi|17366458|sp|Q14573|IP3T_HUMAN Inositol 1,4,5-trisphosphate re...  1581   0.0
gi|6981110|ref|NP_037270.1| inositol 1, 4, 5-triphosphate recept...  1575   0.0
gi|27805963|ref|NP_776795.1| inositol 1,4,5-triphosphate recepto...  1570   0.0
gi|31217824|ref|XP_316515.1| ENSANGP00000004303 [Anopheles gambi...  1541   0.0
gi|50760465|ref|XP_418035.1| PREDICTED: similar to Inositol 1,4,...  1271   0.0
gi|476810|pir||A40743 IP3 receptor, XIP3R - African clawed frog ...  1229   0.0
gi|44888998|sp|P29993|IP3R_DROME Inositol 1,4,5-trisphosphate re...  1123   0.0
gi|24644261|ref|NP_730942.1| CG1063-PA [Drosophila melanogaster]...  1122   0.0
gi|24644259|ref|NP_730941.1| CG1063-PB [Drosophila melanogaster]...  1122   0.0
gi|5689748|emb|CAB51853.1| inositol 1,4,5-trisphosphate receptor...  1102   0.0
gi|345496|pir||A43360 inositol 1,4,5-trisphosphate receptor - fr...  1100   0.0
gi|111838|pir||A36579 inositol 1,4,5-triphosphate receptor 1 - r...  1055   0.0
gi|17366467|sp|Q14643|IP3R_HUMAN Inositol 1,4,5-trisphosphate re...  1054   0.0
gi|111839|pir||B36579 inositol 1,4,5-triphosphate receptor 2 - r...  1053   0.0
gi|47219802|emb|CAG03429.1| unnamed protein product [Tetraodon n...   976   0.0
gi|50754604|ref|XP_414438.1| PREDICTED: similar to inositol 1,4,...   918   0.0
gi|47229530|emb|CAG06726.1| unnamed protein product [Tetraodon n...   916   0.0
gi|19388011|gb|AAH25805.1| Itpr5 protein [Mus musculus]               837   0.0
gi|47227347|emb|CAF96896.1| unnamed protein product [Tetraodon n...   744   0.0
gi|21362620|sp||Q9Z329_2 [Segment 2 of 2] Inositol 1,4,5-trispho...   667   0.0
gi|26339686|dbj|BAC33514.1| unnamed protein product [Mus musculus]    657   0.0
gi|47212327|emb|CAF91265.1| unnamed protein product [Tetraodon n...   636   e-180
gi|26324446|dbj|BAC25977.1| unnamed protein product [Mus musculus]    585   e-165
gi|48095094|ref|XP_392236.1| similar to CG1063-PB [Apis mellifera]    504   e-140
gi|50582469|dbj|BAD32702.1| LIBRA [synthetic construct]               476   e-132
gi|26326875|dbj|BAC27181.1| unnamed protein product [Mus musculus]    467   e-129
gi|46189240|gb|AAH68269.1| Unknown (protein for IMAGE:30024505) ...   414   e-113
gi|26324442|dbj|BAC25975.1| unnamed protein product [Mus musculus]    360   3e-97
gi|26348319|dbj|BAC37799.1| unnamed protein product [Mus musculus]    360   3e-97
gi|1196648|gb|AAA88319.1| putative >gnl|BL_ORD_ID|819024 gi|1309...   342   7e-92
gi|16307548|gb|AAH10323.1| Itpr3 protein [Mus musculus]               338   1e-90
gi|26338934|dbj|BAC33138.1| unnamed protein product [Mus musculus]    332   1e-88
gi|2119532|pir||I48607 inositol 1,4,5-trisphosphate receptor typ...   327   4e-87
gi|26336805|dbj|BAC32085.1| unnamed protein product [Mus musculus]    315   2e-83
gi|7848|emb|CAA79220.1| inositol 1,4, 5-triphosphate receptor [D...   311   2e-82
gi|477498|pir||A49131 inositol 1,4,5-triphosphate receptor Dip /...   307   3e-81
gi|27574053|pdb|1N4K|A Chain A, Crystal Structure Of The Inosito...   273   5e-71
gi|21362619|sp||Q9Z329_1 [Segment 1 of 2] Inositol 1,4,5-trispho...   257   3e-66
gi|11245468|gb|AAG33627.1| type I inositol triphosphate receptor...   207   4e-51
gi|1098969|gb|AAC53100.1| inositol 1,4,5-trisphosphate receptor       203   5e-50
gi|1495698|emb|CAA94862.1| inositol 1,4,5-trisphosphate receptor...   197   4e-48
gi|17366368|sp|P70227|IP3T_MOUSE Inositol 1,4,5-trisphosphate re...   197   4e-48
gi|3786318|dbj|BAA33961.1| inositol 1,4,5-trisphosphate receptor...   192   1e-46
gi|9910290|ref|NP_064307.1| inositol 1,4,5-triphosphate receptor...   192   1e-46
gi|50405284|ref|YP_054376.1| Inositol 1,4,5-triphosphate recepto...   178   2e-42
gi|39594392|emb|CAE71970.1| Hypothetical protein CBG19042 [Caeno...   139   2e-30
gi|1871447|dbj|BAA08309.1| ryanodine receptor [Caenorhabditis el...   139   2e-30
gi|17564924|ref|NP_504753.1| UNCoordinated locomotion UNC-68, Ke...   139   2e-30
gi|26335003|dbj|BAC31202.1| unnamed protein product [Mus musculus]    136   1e-29
gi|2809067|dbj|BAA24504.1| inositol 1,4,5-triphosphate recepter ...   132   2e-28
gi|7441639|pir||PC4441 inositol 1,4,5-triphosphate receptor - ho...   132   2e-28
gi|47221064|emb|CAG12758.1| unnamed protein product [Tetraodon n...   129   1e-27
gi|2108232|gb|AAB58117.1| [Prot=RyR1 isform from fish] Fish RyR1...   129   2e-27
gi|38086189|ref|XP_133347.2| similar to ryanodine receptor 1 (sk...   127   4e-27
gi|3845349|gb|AAC71651.1| RYNR_HUMAN [AA 4362- 5032]; SKELETAL M...   126   1e-26
gi|107631|pir||A35041 ryanodine receptor type 1, skeletal muscle...   126   1e-26
gi|164429|gb|AAA31022.1| calcium release channel protein              126   1e-26
gi|1937|emb|CAA44674.1| calcium release channel [Sus scrofa]          126   1e-26
gi|226386|prf||1509336A ryanodine receptor                            126   1e-26
gi|134134|sp|P11716|RYR1_RABIT Ryanodine receptor 1 (Skeletal mu...   126   1e-26
gi|1079342|pir||A54161 ryanodine-binding protein alpha form - bu...   126   1e-26
gi|2134400|pir||S66572 ryanodine receptor type 3 - chicken            126   1e-26
gi|46048744|ref|NP_996757.1| ryanodine receptor type 3 [Gallus g...   126   1e-26
gi|30109246|gb|AAH51248.1| Ryr1 protein [Mus musculus]                126   1e-26
gi|33585472|gb|AAH55487.1| Ryr1 protein [Mus musculus]                126   1e-26
gi|10863871|ref|NP_000531.1| ryanodine receptor 1 (skeletal); sa...   126   1e-26
gi|34855645|ref|XP_341819.1| ryanodine receptor 1 (skeletal) [Ra...   126   1e-26
gi|45597439|ref|NP_033135.1| ryanodine receptor 1, skeletal musc...   126   1e-26
gi|1173335|sp|P16960|RYR1_PIG Ryanodine receptor 1 (Skeletal mus...   126   1e-26
gi|346611|pir||S27272 ryanodine receptor, brain - rabbit >gnl|BL...   125   1e-26
gi|37704386|ref|NP_001027.2| ryanodine receptor 3 [Homo sapiens]      125   1e-26
gi|18202506|sp|Q15413|RYR3_HUMAN Ryanodine receptor 3 (Brain-typ...   125   1e-26
gi|2696015|dbj|BAA23795.1| brain ryanodine receptor [Homo sapiens]    125   1e-26
gi|1526615|emb|CAA69029.1| ryanodine receptor type 3 [Mustela vi...   125   1e-26
gi|7441641|pir||S74173 ryanodine receptor 3 - Mustela sp              125   1e-26
gi|38075725|ref|XP_130497.2| ryanodine receptor 3 [Mus musculus]      125   1e-26
gi|2136637|pir||I46646 ryanodine receptor, skeletal muscle - pig...   125   1e-26
gi|164646|gb|AAA31118.1| ryanodine receptor [Sus scrofa]              125   1e-26
gi|693803|gb|AAB32056.1| ryanodine receptor, RYR=ryanodine-sensi...   125   1e-26
gi|228961|prf||1814504A ryanodine receptor beta4                      124   3e-26
gi|29501272|dbj|BAA04647.2| ryanodine receptor beta isoform [Ran...   124   4e-26
gi|1079343|pir||B54161 ryanodine-binding protein beta form - bul...   124   4e-26
gi|47218152|emb|CAG10072.1| unnamed protein product [Tetraodon n...   124   5e-26
gi|2119535|pir||I48741 ryanodine receptor type 1 - mouse (fragme...   122   1e-25
gi|833799|emb|CAA78855.1| ssryr_cds [Sus scrofa]                      122   2e-25
gi|28628791|gb|AAO49356.1| ryanodine receptor pRyR [Periplaneta ...   122   2e-25
gi|1841943|emb|CAA65105.1| ryanodine receptor 2 [Sus scrofa]          122   2e-25
gi|1245376|gb|AAA93465.1| cardiac ryanodine receptor                  122   2e-25
gi|401055|sp|P30957|RYR2_RABIT Ryanodine receptor 2 (Cardiac mus...   122   2e-25
gi|1871612|emb|CAA69138.1| ryanodine receptor [Oryctolagus cunic...   122   2e-25
gi|456984|gb|AAB29457.1| ryanodine receptor, calcium release cha...   121   3e-25
gi|630870|pir||S40450 ryanodine receptor/calcium release channel...   121   3e-25
gi|2160476|dbj|BAA41470.1| ryanodine receptor homologue [Drosoph...   121   3e-25
gi|2119534|pir||I48742 ryanodine receptor type 2 - mouse (fragme...   121   3e-25
gi|17352469|ref|NP_476993.1| CG10844-PC [Drosophila melanogaster...   121   3e-25
gi|17352465|ref|NP_476991.1| CG10844-PA [Drosophila melanogaster...   121   3e-25
gi|50740993|ref|XP_419553.1| PREDICTED: similar to Ryanodine rec...   121   3e-25
gi|2160478|dbj|BAA04212.1| ryanodine receptor homologue [Drosoph...   121   3e-25
gi|48094968|ref|XP_392217.1| similar to ENSANGP00000023306 [Apis...   121   3e-25
gi|2160477|dbj|BAA41471.1| ryanodine receptor homologue [Drosoph...   121   3e-25
gi|1871614|emb|CAA69139.1| ryanodine receptor [Oryctolagus cunic...   121   3e-25
gi|13569850|ref|NP_076357.1| ryanodine receptor 2, cardiac; calc...   121   3e-25
gi|4506757|ref|NP_001026.1| ryanodine receptor 2 [Homo sapiens] ...   121   3e-25
gi|17352471|ref|NP_476994.1| CG10844-PD [Drosophila melanogaster...   121   3e-25
gi|17352467|ref|NP_476992.1| CG10844-PB [Drosophila melanogaster...   121   3e-25
gi|4102119|gb|AAD01425.1| ryanodine receptor [Heliothis virescens]    120   4e-25
gi|227245|prf||1617118A ryanodine receptor                            119   2e-24
gi|763545|gb|AAA64955.1| ryanodine receptor type 1                    119   2e-24
gi|763549|gb|AAA64957.1| ryanodine receptor type 3                    118   2e-24
gi|18656155|dbj|BAB84714.1| ryanodine receptor [Hemicentrotus pu...   118   2e-24
gi|31231655|ref|XP_318561.1| ENSANGP00000019607 [Anopheles gambi...   118   3e-24
gi|31231666|ref|XP_318563.1| ENSANGP00000023306 [Anopheles gambi...   118   3e-24
gi|31231660|ref|XP_318562.1| ENSANGP00000022873 [Anopheles gambi...   118   3e-24
gi|1841945|emb|CAA65104.1| ryanodine receptor 3 [Sus scrofa]          117   6e-24
gi|2970625|gb|AAC06013.1| ryanodine receptor [Homarus americanus]     116   8e-24
gi|1212910|emb|CAA64562.1| ryanodine receptor type 1 [Gallus gal...   116   8e-24
gi|34876277|ref|XP_341549.1| ryanodine receptor type II [Rattus ...   113   9e-23
gi|1055287|gb|AAC53099.1| inositol 1,4,5-trisphosphate receptor       112   2e-22
gi|477885|pir||B49131 ryanodine receptor Dry / intracellular Ca(...   111   3e-22
gi|47227185|emb|CAG00547.1| unnamed protein product [Tetraodon n...   110   5e-22
gi|405719|emb|CAA52326.1| ryanodine receptor type 3 [Homo sapiens]    110   5e-22
gi|7879|emb|CAA79221.1| ryanodine receptor [Drosophila melanogas...   105   2e-20
gi|763547|gb|AAA64956.1| ryanodine receptor type 2                     96   1e-17
gi|34856658|ref|XP_342492.1| ryanodine receptor 3 [Rattus norveg...    95   3e-17
gi|46560604|gb|AAT00630.1| inositol 1,4,5-triphosphate receptor-...    94   6e-17
gi|47196873|emb|CAF89254.1| unnamed protein product [Tetraodon n...    85   4e-14
gi|13879583|gb|AAH06773.1| Itpr3 protein [Mus musculus]                84   5e-14
gi|5823031|gb|AAD53013.1| ryanodine receptor [Expression vector ...    82   2e-13
gi|1363229|pir||S56107 ryanodine receptor 3 - mouse (fragment) >...    81   4e-13
gi|1030708|dbj|BAA07391.1| skeletal muscle ryanodine receptor [M...    80   7e-13
gi|1583174|prf||2120276A ryanodine receptor:ISOTYPE=1                  80   9e-13
gi|1030710|dbj|BAA07392.1| cardiac ryanodine receptor [Mus muscu...    79   1e-12
gi|4262086|gb|AAD14386.1| inositol 1,4,5 trisphosphate receptor ...    79   2e-12
gi|9187975|emb|CAB97127.1| inositol 1,4,5-trisphosphate receptor...    78   4e-12
gi|1363227|pir||S56105 ryanodine receptor 1 - mouse (fragment)         77   6e-12
gi|2136552|pir||S68273 inositol 1,4,5-trisphosphate receptor s1 ...    76   1e-11
gi|4868341|gb|AAD31270.1| ryanodine receptor type 1 [Rattus norv...    76   1e-11
gi|38086191|ref|XP_355874.1| similar to ryanodine receptor [Mus ...    75   3e-11
gi|4868345|gb|AAD31272.1| ryanodine receptor type 3 [Rattus norv...    75   4e-11
gi|2136136|pir||S66631 ryanodine receptor 3 - human (fragment) >...    74   8e-11
gi|47224547|emb|CAG03531.1| unnamed protein product [Tetraodon n...    73   1e-10
gi|47230257|emb|CAG10671.1| unnamed protein product [Tetraodon n...    71   5e-10
gi|29165716|gb|AAH43140.1| Similar to ryanodine receptor 2, card...    68   3e-09
gi|1054963|gb|AAB51330.1| inositol 1,4,5-trisphosphate receptor        68   4e-09
gi|47209126|emb|CAF94369.1| unnamed protein product [Tetraodon n...    65   3e-08
gi|15824345|gb|AAL09307.1| skeletal muscle ryanodine receptor [C...    62   2e-07
gi|1769447|emb|CAA89860.1| skeletal muscle ryanodine receptor [S...    59   2e-06
gi|34855651|ref|XP_341822.1| similar to Ryanodine receptor 2 (Ca...    59   2e-06
gi|7656700|gb|AAF66076.1| Homo sapiens ryanodine receptor 1 (ske...    56   1e-05
gi|34855647|ref|XP_341820.1| similar to ryanodine receptor [Ratt...    55   3e-05
gi|47224548|emb|CAG03532.1| unnamed protein product [Tetraodon n...    55   3e-05
gi|47224546|emb|CAG03530.1| unnamed protein product [Tetraodon n...    54   5e-05
gi|1930136|gb|AAB70013.1| ryanodine receptor type II [Rattus nor...    52   3e-04
gi|47230258|emb|CAG10672.1| unnamed protein product [Tetraodon n...    50   0.001
gi|34857574|ref|XP_345418.1| similar to Ryanodine receptor 3 (Br...    49   0.002
gi|38075727|ref|XP_355386.1| similar to Ryanodine receptor 3 (Br...    49   0.002
gi|2136606|pir||I47214 probable brain ryanodine receptor - pig (...    49   0.002
gi|1935|emb|CAA48318.1| calcium release channel [Sus scrofa]           49   0.002
gi|4102115|gb|AAD01423.1| ryanodine receptor [Heliothis virescens]     48   0.004
gi|2136485|pir||I47213 cardiac muscle ryanodine receptor - pig (...    48   0.005
gi|1022321|emb|CAA62975.1| ryanodine receptor [Homo sapiens]           48   0.005
gi|111837|pir||B38641 inositol 1,4,5-triphosphate receptor, shor...    48   0.005
gi|34876273|ref|XP_225491.2| similar to cardiac Ca2+ release cha...    48   0.005
gi|13397939|emb|CAC34624.1| skeletal muscle ryanodine receptor [...    47   0.006
gi|562096|gb|AAA60467.1| skeletal muscle ryanodine receptor            47   0.011
gi|2582751|emb|CAA05503.1| ryanodine receptor 3 [Homo sapiens]         46   0.014
gi|204969|gb|AAA41448.1| inositol 1,4,5-trisphosphate receptor         46   0.018
gi|2305244|gb|AAB65756.1| ryanodine receptor 1 [Rattus norvegicus]     45   0.031
gi|5731972|gb|AAD48899.1| ryanodine receptor type 1 [Rattus norv...    44   0.053
gi|2305248|gb|AAB65758.1| ryanodine receptor 3 [Rattus norvegicus]     44   0.053
gi|47209654|emb|CAF92459.1| unnamed protein product [Tetraodon n...    44   0.091
gi|2305246|gb|AAB65757.1| ryanodine receptor 2 [Rattus norvegicus]     44   0.091
gi|543822|sp|Q01613|APX_XENLA Apical protein (APX) >gnl|BL_ORD_I...    42   0.26
gi|47179465|emb|CAG14775.1| unnamed protein product [Tetraodon n...    33   0.28
gi|23491382|gb|EAA22927.1| hypothetical protein [Plasmodium yoel...    41   0.59
gi|19113921|ref|NP_593009.1| hypothetical coiled-coil protein [S...    40   1.0
gi|39583895|emb|CAE63985.1| Hypothetical protein CBG08577 [Caeno...    40   1.3
gi|50302181|ref|XP_451024.1| unnamed protein product [Kluyveromy...    40   1.3
gi|4868343|gb|AAD31271.1| ryanodine receptor type 2 [Rattus norv...    39   1.7
gi|111836|pir||A38641 inositol 1,4,5-triphosphate receptor, long...    39   1.7
gi|5852122|emb|CAB55367.1| putative tubulin-tyrosine ligase [Lei...    39   1.7
gi|37683071|gb|AAQ98613.1| ryanodine receptor 1 [Equus caballus]       39   1.7
gi|2119536|pir||I48743 ryanodine receptor type 3 - mouse (fragme...    39   2.2
gi|50539838|ref|NP_001002385.1| zgc:92052 [Danio rerio] >gnl|BL_...    39   2.9
gi|46227114|gb|EAK88064.1| protein with forkhead associated (FHA...    38   3.8
gi|8170741|gb|AAB25128.2| rat E-box-binding protein; REB beta [R...    38   5.0
gi|28573169|ref|NP_788597.1| CG32940-PA [Drosophila melanogaster...    38   5.0
gi|112957|sp|P05095|AACT_DICDI Alpha-actinin, non-muscular (F-ac...    38   5.0
gi|28573173|ref|NP_788600.1| CG32940-PD [Drosophila melanogaster...    38   5.0
gi|21686697|ref|NP_663197.1| hypothetical protein [Phthorimaea o...    38   5.0
gi|6981636|ref|NP_037308.1| transcription factor 12 [Rattus norv...    38   5.0
gi|49067821|ref|XP_398200.1| hypothetical protein UM00585.1 [Ust...    37   6.5
gi|46229305|gb|EAK90154.1| Low complexity hypothetical protein [...    37   6.5
gi|32398946|emb|CAD98411.1| similarity to rod-like tail of sever...    37   6.5
gi|108755|pir||A38318 inositol 1,4,5-triphosphate receptor - bov...    37   6.5
gi|25012112|ref|NP_736507.1| unknown [Streptococcus agalactiae N...    37   8.5
gi|50747376|ref|XP_420851.1| PREDICTED: similar to RNA polymeras...    37   8.5
gi|41147656|ref|XP_168583.4| similar to intestinal membrane muci...    37   8.5
gi|50762120|ref|XP_424943.1| PREDICTED: similar to coiled-coil d...    37   8.5
gi|26189984|emb|CAD34591.1| heme oxygenase [Ceratodon purpureus]       37   8.5
gi|21243825|ref|NP_643407.1| PilL protein [Xanthomonas axonopodi...    37   8.5
gi|109532|pir||S19958 basic helix-loop-helix transcription facto...    37   8.5
gi|6755730|ref|NP_035674.1| transcription factor 12 [Mus musculu...    37   8.5
gi|23123961|ref|ZP_00105984.1| COG0642: Signal transduction hist...    37   8.5


>gi|17541126|ref|NP_501253.1| inositol 1 4 5-Triphosphate Receptor,
            DEfecation Cycle abnormal DEC-4, Let-23 Fertility
            Effector/regulator LFE-1 (327.2 kD) (itr-1)
            [Caenorhabditis elegans]
 gi|5262811|emb|CAB45863.1| inositol 1,4,5-trisphosphate receptor
            [Caenorhabditis elegans]
 gi|14574167|gb|AAK68365.1| Inositol triphosphate receptor protein 1,
            isoform e [Caenorhabditis elegans]
          Length = 2857

 Score = 5546 bits (14386), Expect = 0.0
 Identities = 2774/2857 (97%), Positives = 2774/2857 (97%)
 Frame = +1

Query: 1    MDYDYRRRVLERNIGMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLS 180
            MDYDYRRRVLERNIGMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLS
Sbjct: 1    MDYDYRRRVLERNIGMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLS 60

Query: 181  TLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDD 360
            TLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDD
Sbjct: 61   TLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDD 120

Query: 361  DLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNA 540
            DLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNA
Sbjct: 121  DLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNA 180

Query: 541  MKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSF 720
            MKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSF
Sbjct: 181  MKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSF 240

Query: 721  NLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPK 900
            NLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPK
Sbjct: 241  NLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPK 300

Query: 901  QNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYL 1080
            QNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYL
Sbjct: 301  QNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYL 360

Query: 1081 SAEPSQVQVKPAMNGRPPLLSALSQKSRPMLERTNNPMAMYSDGPNGVTNESTDTTQQNI 1260
            SAEPSQVQVKPAMNGRPPLLSALSQKSRPMLERTNNPMAMYSDGPNGVTNESTDTTQQNI
Sbjct: 361  SAEPSQVQVKPAMNGRPPLLSALSQKSRPMLERTNNPMAMYSDGPNGVTNESTDTTQQNI 420

Query: 1261 PSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATE 1440
            PSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATE
Sbjct: 421  PSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATE 480

Query: 1441 KQNLHYSSKNEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIK 1620
            KQNLHYSSKNEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIK
Sbjct: 481  KQNLHYSSKNEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIK 540

Query: 1621 IGQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVF 1800
            IGQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVF
Sbjct: 541  IGQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVF 600

Query: 1801 LLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLA 1980
            LLLKAPFLPRQGTT             DSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLA
Sbjct: 601  LLLKAPFLPRQGTTELGPLLSSPSELSDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLA 660

Query: 1981 EKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLA 2160
            EKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLA
Sbjct: 661  EKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLA 720

Query: 2161 DLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKS 2340
            DLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKS
Sbjct: 721  DLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKS 780

Query: 2341 NSDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLP 2520
            NSDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLP
Sbjct: 781  NSDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLP 840

Query: 2521 YDLRGSFTRLMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIG 2700
            YDLRGSFTRLMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIG
Sbjct: 841  YDLRGSFTRLMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIG 900

Query: 2701 EGIAHKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLT 2880
            EGIAHKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLT
Sbjct: 901  EGIAHKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLT 960

Query: 2881 QNLLAIINEGPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTK 3060
            QNLLAIINEGPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTK
Sbjct: 961  QNLLAIINEGPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTK 1020

Query: 3061 EGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMAS 3240
            EGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMAS
Sbjct: 1021 EGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMAS 1080

Query: 3241 ELYDAIYRSSGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLED 3420
            ELYDAIYRSSGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLED
Sbjct: 1081 ELYDAIYRSSGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLED 1140

Query: 3421 LKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHD 3600
            LKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHD
Sbjct: 1141 LKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHD 1200

Query: 3601 LLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELS 3780
            LLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELS
Sbjct: 1201 LLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELS 1260

Query: 3781 DKAPLIAYPLIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHD 3960
            DKAPLIAYPLIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHD
Sbjct: 1261 DKAPLIAYPLIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHD 1320

Query: 3961 HDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRN 4140
            HDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRN
Sbjct: 1321 HDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRN 1380

Query: 4141 NRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASD 4320
            NRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASD
Sbjct: 1381 NRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASD 1440

Query: 4321 EVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELK 4500
            EVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELK
Sbjct: 1441 EVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELK 1500

Query: 4501 CASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLE 4680
            CASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLE
Sbjct: 1501 CASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLE 1560

Query: 4681 DIRSLRVEKLTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLL 4860
            DIRSLRVEKLTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLL
Sbjct: 1561 DIRSLRVEKLTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLL 1620

Query: 4861 ELTYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQ 5040
            ELTYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQ
Sbjct: 1621 ELTYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQ 1680

Query: 5041 QAASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPL 5220
            QAASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPL
Sbjct: 1681 QAASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPL 1740

Query: 5221 HAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQT 5400
            HAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQT
Sbjct: 1741 HAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQT 1800

Query: 5401 LCKMCDCTKQQLTHQGHRVYNSSVEKGXXXXXXXXXXYFGHHNNHHPPLDRQQSXXXXXX 5580
            LCKMCDCTKQQLTHQGHRVYNSSVEKG          YFGHHNNHHPPLDRQQS
Sbjct: 1801 LCKMCDCTKQQLTHQGHRVYNSSVEKGQQLRQLLLQRYFGHHNNHHPPLDRQQSKIGEVI 1860

Query: 5581 XXXXXXXXXTWSQERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEG 5760
                     TWSQERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEG
Sbjct: 1861 EAVKEKKEETWSQERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEG 1920

Query: 5761 NDKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRLKSDMMSCSDSKPKVSSTVLTPLID 5940
            NDKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRLKSDMMSCSDSKPKVSSTVLTPLID
Sbjct: 1921 NDKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRLKSDMMSCSDSKPKVSSTVLTPLID 1980

Query: 5941 AGDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPEVALVE 6120
            AGDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPEVALVE
Sbjct: 1981 AGDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPEVALVE 2040

Query: 6121 PILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFGEIGEH 6300
            PILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFGEIGEH
Sbjct: 2041 PILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFGEIGEH 2100

Query: 6301 NFSLITQTLATLTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADDHMELALEIK 6480
            NFSLITQTLATLTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADDHMELALEIK
Sbjct: 2101 NFSLITQTLATLTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADDHMELALEIK 2160

Query: 6481 SQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISR 6660
            SQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISR
Sbjct: 2161 SQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISR 2220

Query: 6661 DLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSV 6840
            DLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSV
Sbjct: 2221 DLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSV 2280

Query: 6841 DPREVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRT 7020
            DPREVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRT
Sbjct: 2281 DPREVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRT 2340

Query: 7021 LERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRK 7200
            LERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRK
Sbjct: 2341 LERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRK 2400

Query: 7201 WLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFAVFSSFLLAH 7380
            WLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFAVFSSFLLAH
Sbjct: 2401 WLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFAVFSSFLLAH 2460

Query: 7381 YLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLED 7560
            YLRHDKIYLHKT               IGVTLTLYIFGILQLVNKIVHVVAFVSNKGLED
Sbjct: 2461 YLRHDKIYLHKTSLLILASLCFLLLSSIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLED 2520

Query: 7561 RPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQS 7740
            RPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQS
Sbjct: 2521 RPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQS 2580

Query: 7741 IVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSETCPSEGCPGLQ 7920
            IVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSETCPSEGCPGLQ
Sbjct: 2581 IVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSETCPSEGCPGLQ 2640

Query: 7921 PSXXXXXXXXXXXXSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMT 8100
            PS            SCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMT
Sbjct: 2641 PSEKDDNDDEKKVKSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMT 2700

Query: 8101 XXXXXXXXXXXXXXXXXXDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHR 8280
                              DTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHR
Sbjct: 2701 FFVVLIVIVLNLIFGVIIDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHR 2760

Query: 8281 ETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQ 8460
            ETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQ
Sbjct: 2761 ETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQ 2820

Query: 8461 SEVKQMKDQLLQMMTLMREIISQNEESRAFMEQFQPR 8571
            SEVKQMKDQLLQMMTLMREIISQNEESRAFMEQFQPR
Sbjct: 2821 SEVKQMKDQLLQMMTLMREIISQNEESRAFMEQFQPR 2857


>gi|7500399|pir||T32550 hypothetical protein F33D4.2a - Caenorhabditis
            elegans
          Length = 2848

 Score = 5508 bits (14289), Expect = 0.0
 Identities = 2759/2848 (96%), Positives = 2759/2848 (96%), Gaps = 6/2848 (0%)
 Frame = +1

Query: 46   MALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKD 225
            MALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKD
Sbjct: 1    MALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKD 60

Query: 226  GRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKERE 405
            GRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKERE
Sbjct: 61   GRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKERE 120

Query: 406  ENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWF 585
            ENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWF
Sbjct: 121  ENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWF 180

Query: 586  IIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLN 765
            IIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLN
Sbjct: 181  IIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLN 240

Query: 766  EPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNR 945
            EPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNR
Sbjct: 241  EPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNR 300

Query: 946  PSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNG 1125
            PSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNG
Sbjct: 301  PSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNG 360

Query: 1126 RPPLLSALSQKSRPMLERTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPE 1305
            RPPLLSALSQKSRPMLERTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPE
Sbjct: 361  RPPLLSALSQKSRPMLERTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPE 420

Query: 1306 EDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWV 1485
            EDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWV
Sbjct: 421  EDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWV 480

Query: 1486 KVICEKNRVDKETFALLPVNPDE------VRDLDFANDACKALRNFIKLIKIGQVISKES 1647
            KVICEKNRVDKETFALLPVNPDE      VRDLDFANDACKALRNFIKLIKIGQVISKES
Sbjct: 481  KVICEKNRVDKETFALLPVNPDEASQSLNVRDLDFANDACKALRNFIKLIKIGQVISKES 540

Query: 1648 INSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLP 1827
            INSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLP
Sbjct: 541  INSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLP 600

Query: 1828 RQGTTXXXXXXXXXXXXXDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQ 2007
            RQGTT             DSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQ
Sbjct: 601  RQGTTELGPLLSSPSELSDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQ 660

Query: 2008 IGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEA 2187
            IGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEA
Sbjct: 661  IGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEA 720

Query: 2188 NKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSNSDDAEHLD 2367
            NKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSNSDDAEHLD
Sbjct: 721  NKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSNSDDAEHLD 780

Query: 2368 YYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTR 2547
            YYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTR
Sbjct: 781  YYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTR 840

Query: 2548 LMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLA 2727
            LMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLA
Sbjct: 841  LMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLA 900

Query: 2728 TVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINE 2907
            TVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINE
Sbjct: 901  TVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINE 960

Query: 2908 GPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKT 3087
            GPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKT
Sbjct: 961  GPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKT 1020

Query: 3088 KLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASELYDAIYRS 3267
            KLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASELYDAIYRS
Sbjct: 1021 KLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASELYDAIYRS 1080

Query: 3268 SGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVS 3447
            SGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVS
Sbjct: 1081 SGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVS 1140

Query: 3448 NNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSP 3627
            NNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSP
Sbjct: 1141 NNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSP 1200

Query: 3628 RAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYP 3807
            RAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYP
Sbjct: 1201 RAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYP 1260

Query: 3808 LIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITL 3987
            LIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITL
Sbjct: 1261 LIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITL 1320

Query: 3988 SHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVP 4167
            SHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVP
Sbjct: 1321 SHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVP 1380

Query: 4168 EELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDN 4347
            EELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDN
Sbjct: 1381 EELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDN 1440

Query: 4348 ASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDH 4527
            ASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDH
Sbjct: 1441 ASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDH 1500

Query: 4528 IVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEK 4707
            IVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEK
Sbjct: 1501 IVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEK 1560

Query: 4708 LTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGK 4887
            LTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGK
Sbjct: 1561 LTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGK 1620

Query: 4888 LRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWI 5067
            LRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWI
Sbjct: 1621 LRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWI 1680

Query: 5068 GIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLV 5247
            GIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLV
Sbjct: 1681 GIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLV 1740

Query: 5248 EVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTK 5427
            EVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTK
Sbjct: 1741 EVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTK 1800

Query: 5428 QQLTHQGHRVYNSSVEKGXXXXXXXXXXYFGHHNNHHPPLDRQQSXXXXXXXXXXXXXXX 5607
            QQLTHQGHRVYNSSVEKG          YFGHHNNHHPPLDRQQS
Sbjct: 1801 QQLTHQGHRVYNSSVEKGQQLRQLLLQRYFGHHNNHHPPLDRQQSKIGEVIEAVKEKKEE 1860

Query: 5608 TWSQERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFY 5787
            TWSQERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFY
Sbjct: 1861 TWSQERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFY 1920

Query: 5788 MRMKQKDIHEPFFKAILTRIQTAQNRLKSDMMSCSDSKPKVSSTVLTPLIDAGDTGFNGA 5967
            MRMKQKDIHEPFFKAILTRIQTAQNRLKSDMMSCSDSKPKVSSTVLTPLIDAGDTGFNGA
Sbjct: 1921 MRMKQKDIHEPFFKAILTRIQTAQNRLKSDMMSCSDSKPKVSSTVLTPLIDAGDTGFNGA 1980

Query: 5968 LFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPEVALVEPILRVLQLL 6147
            LFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPEVALVEPILRVLQLL
Sbjct: 1981 LFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPEVALVEPILRVLQLL 2040

Query: 6148 CENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFGEIGEHNFSLITQTL 6327
            CENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFGEIGEHNFSLITQTL
Sbjct: 2041 CENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFGEIGEHNFSLITQTL 2100

Query: 6328 ATLTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLA 6507
            ATLTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLA
Sbjct: 2101 ATLTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLA 2160

Query: 6508 IMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDD 6687
            IMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDD
Sbjct: 2161 IMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDD 2220

Query: 6688 LKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNI 6867
            LKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNI
Sbjct: 2221 LKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNI 2280

Query: 6868 YILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPIN 7047
            YILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPIN
Sbjct: 2281 YILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPIN 2340

Query: 7048 DICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRL 7227
            DICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRL
Sbjct: 2341 DICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRL 2400

Query: 7228 PLWTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFAVFSSFLLAHYLRHDKIYL 7407
            PLWTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFAVFSSFLLAHYLRHDKIYL
Sbjct: 2401 PLWTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFAVFSSFLLAHYLRHDKIYL 2460

Query: 7408 HKTXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILAC 7587
            HKT               IGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILAC
Sbjct: 2461 HKTSLLILASLCFLLLSSIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILAC 2520

Query: 7588 RNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLAL 7767
            RNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLAL
Sbjct: 2521 RNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLAL 2580

Query: 7768 ILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSETCPSEGCPGLQPSXXXXXXX 7947
            ILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSETCPSEGCPGLQPS
Sbjct: 2581 ILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSETCPSEGCPGLQPSEKDDNDD 2640

Query: 7948 XXXXXSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTXXXXXXXXX 8127
                 SCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMT
Sbjct: 2641 EKKVKSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTFFVVLIVIV 2700

Query: 8128 XXXXXXXXXDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHY 8307
                     DTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHY
Sbjct: 2701 LNLIFGVIIDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHY 2760

Query: 8308 LYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQ 8487
            LYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQ
Sbjct: 2761 LYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQ 2820

Query: 8488 LLQMMTLMREIISQNEESRAFMEQFQPR 8571
            LLQMMTLMREIISQNEESRAFMEQFQPR
Sbjct: 2821 LLQMMTLMREIISQNEESRAFMEQFQPR 2848


>gi|17541128|ref|NP_501252.1| inositol 1 4 5-Triphosphate Receptor,
            DEfecation Cycle abnormal DEC-4, Let-23 Fertility
            Effector/regulator LFE-1 (325.9 kD) (itr-1)
            [Caenorhabditis elegans]
 gi|5262805|emb|CAB45860.1| inositol 1,4,5-trisphosphate receptor
            [Caenorhabditis elegans]
 gi|6175844|gb|AAF05302.1| inositol 1,4,5-trisphosphate receptor
            [Caenorhabditis elegans]
 gi|14574168|gb|AAK68366.1| Inositol triphosphate receptor protein 1,
            isoform f [Caenorhabditis elegans]
          Length = 2846

 Score = 5472 bits (14195), Expect = 0.0
 Identities = 2747/2866 (95%), Positives = 2754/2866 (95%), Gaps = 9/2866 (0%)
 Frame = +1

Query: 1    MDYDYRRRVLERNIGMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLS 180
            MDYDYRRRVLERNIGMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLS
Sbjct: 1    MDYDYRRRVLERNIGMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLS 60

Query: 181  TLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDD 360
            TLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDD
Sbjct: 61   TLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDD 120

Query: 361  DLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNA 540
            DLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNA
Sbjct: 121  DLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNA 180

Query: 541  MKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSF 720
            MKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSF
Sbjct: 181  MKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSF 240

Query: 721  NLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPK 900
            NLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPK
Sbjct: 241  NLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPK 300

Query: 901  QNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYL 1080
            QNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYL
Sbjct: 301  QNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYL 360

Query: 1081 SAEPSQVQVKPAMNGRPPLLSALSQKSRPMLERTNNPMAMYSDGPNGVTNESTDTTQQNI 1260
            SAEPSQVQVKPAMNGR   L         +  +TNNPMAMYSDGPNGVTNESTDTTQQNI
Sbjct: 361  SAEPSQVQVKPAMNGRRASL---------IYSKTNNPMAMYSDGPNGVTNESTDTTQQNI 411

Query: 1261 PSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATE 1440
            PSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATE
Sbjct: 412  PSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATE 471

Query: 1441 KQNLHYSSKNEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIK 1620
            KQNLHYSSKNEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIK
Sbjct: 472  KQNLHYSSKNEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIK 531

Query: 1621 IGQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVF 1800
            IGQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVF
Sbjct: 532  IGQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVF 591

Query: 1801 LLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLA 1980
            LLLKAPFLPRQGTT             DSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLA
Sbjct: 592  LLLKAPFLPRQGTTELGPLLSSPSELSDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLA 651

Query: 1981 EKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLA 2160
            EKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLA
Sbjct: 652  EKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLA 711

Query: 2161 DLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKS 2340
            DLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKS
Sbjct: 712  DLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKS 771

Query: 2341 NSDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLP 2520
            NSDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLP
Sbjct: 772  NSDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLP 831

Query: 2521 YDLRGSFTRLMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIG 2700
            YDLRGSFTRLMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIG
Sbjct: 832  YDLRGSFTRLMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIG 891

Query: 2701 EGIAHKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLT 2880
            EGIAHKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLT
Sbjct: 892  EGIAHKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLT 951

Query: 2881 QNLLAIINEGPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTK 3060
            QNLLAIINEGPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTK
Sbjct: 952  QNLLAIINEGPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTK 1011

Query: 3061 EGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMAS 3240
            EGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMAS
Sbjct: 1012 EGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMAS 1071

Query: 3241 ELYDAIYRSSGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLED 3420
            ELYDAIYRSSGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLED
Sbjct: 1072 ELYDAIYRSSGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLED 1131

Query: 3421 LKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHD 3600
            LKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHD
Sbjct: 1132 LKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHD 1191

Query: 3601 LLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELS 3780
            LLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELS
Sbjct: 1192 LLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELS 1251

Query: 3781 DKAPLIAYPLIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHD 3960
            DKAPLIAYPLIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHD
Sbjct: 1252 DKAPLIAYPLIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHD 1311

Query: 3961 HDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRN 4140
            HDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRN
Sbjct: 1312 HDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRN 1371

Query: 4141 NRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASD 4320
            NRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASD
Sbjct: 1372 NRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASD 1431

Query: 4321 EVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELK 4500
            EVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELK
Sbjct: 1432 EVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELK 1491

Query: 4501 CASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLE 4680
            CASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLE
Sbjct: 1492 CASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLE 1551

Query: 4681 DIRSLRVEKLTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLL 4860
            DIRSLRVEKLTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLL
Sbjct: 1552 DIRSLRVEKLTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLL 1611

Query: 4861 ELTYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQ 5040
            ELTYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQ
Sbjct: 1612 ELTYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQ 1671

Query: 5041 QAASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPL 5220
            QAASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPL
Sbjct: 1672 QAASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPL 1731

Query: 5221 HAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQT 5400
            HAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQT
Sbjct: 1732 HAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQT 1791

Query: 5401 LCKMCDCTKQQLTHQGHRVYNSSVEKGXXXXXXXXXXYFGHHNNHHPPLDRQQSXXXXXX 5580
            LCKMCDCTKQQLTHQG ++    +++           YFGHHNNHHPPLDRQQS
Sbjct: 1792 LCKMCDCTKQQLTHQGQQLRQLLLQR-----------YFGHHNNHHPPLDRQQSKIGEVI 1840

Query: 5581 XXXXXXXXXTWSQERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEG 5760
                     TWSQERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEG
Sbjct: 1841 EAVKEKKEETWSQERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEG 1900

Query: 5761 NDKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRLKSDMMSCSDSKPKV---------S 5913
            NDKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRLKSDMMSCSDSKPKV         S
Sbjct: 1901 NDKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRLKSDMMSCSDSKPKVSLSATVSRRS 1960

Query: 5914 STVLTPLIDAGDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDA 6093
            STVLTPLIDAGDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDA
Sbjct: 1961 STVLTPLIDAGDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDA 2020

Query: 6094 LPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSL 6273
            LPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSL
Sbjct: 2021 LPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSL 2080

Query: 6274 GVFGEIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADD 6453
            GVFGEIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADD
Sbjct: 2081 GVFGEIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADD 2140

Query: 6454 HMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSN 6633
            HMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSN
Sbjct: 2141 HMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSN 2200

Query: 6634 HHMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDK 6813
            HHMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDK
Sbjct: 2201 HHMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDK 2260

Query: 6814 FNDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQ 6993
            FNDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQ
Sbjct: 2261 FNDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQ 2320

Query: 6994 IEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMI 7173
            IEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMI
Sbjct: 2321 IEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMI 2380

Query: 7174 WQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFA 7353
            WQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFA
Sbjct: 2381 WQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFA 2440

Query: 7354 VFSSFLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVA 7533
            VFSSFLLAHYLRHDKIYLHKT               IGVTLTLYIFGILQLVNKIVHVVA
Sbjct: 2441 VFSSFLLAHYLRHDKIYLHKTSLLILASLCFLLLSSIGVTLTLYIFGILQLVNKIVHVVA 2500

Query: 7534 FVSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVI 7713
            FVSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVI
Sbjct: 2501 FVSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVI 2560

Query: 7714 ASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSETC 7893
            ASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSETC
Sbjct: 2561 ASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSETC 2620

Query: 7894 PSEGCPGLQPSXXXXXXXXXXXXSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMF 8073
            PSEGCPGLQPS            SCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMF
Sbjct: 2621 PSEGCPGLQPSEKDDNDDEKKVKSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMF 2680

Query: 8074 IWRVAYDMTXXXXXXXXXXXXXXXXXXDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDN 8253
            IWRVAYDMT                  DTFGDLRAEKNEKEQILKNNCFICGLDRSRFDN
Sbjct: 2681 IWRVAYDMTFFVVLIVIVLNLIFGVIIDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDN 2740

Query: 8254 RSVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSL 8433
            RSVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSL
Sbjct: 2741 RSVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSL 2800

Query: 8434 QDSELDTDQSEVKQMKDQLLQMMTLMREIISQNEESRAFMEQFQPR 8571
            QDSELDTDQSEVKQMKDQLLQMMTLMREIISQNEESRAFMEQFQPR
Sbjct: 2801 QDSELDTDQSEVKQMKDQLLQMMTLMREIISQNEESRAFMEQFQPR 2846


>gi|14574164|gb|AAK68362.1| Inositol triphosphate receptor protein 1,
            isoform a [Caenorhabditis elegans]
          Length = 2903

 Score = 5472 bits (14194), Expect = 0.0
 Identities = 2746/2865 (95%), Positives = 2750/2865 (95%), Gaps = 9/2865 (0%)
 Frame = +1

Query: 4    DYDYRRRVLERNIGMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLST 183
            D+D     + R   MALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLST
Sbjct: 48   DFDDFEEQIMRKSSMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLST 107

Query: 184  LGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDD 363
            LGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDD
Sbjct: 108  LGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDD 167

Query: 364  LMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAM 543
            LMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAM
Sbjct: 168  LMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAM 227

Query: 544  KVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFN 723
            KVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFN
Sbjct: 228  KVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFN 287

Query: 724  LLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQ 903
            LLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQ
Sbjct: 288  LLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQ 347

Query: 904  NPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLS 1083
            NPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLS
Sbjct: 348  NPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLS 407

Query: 1084 AEPSQVQVKPAMNGRPPLLSALSQKSRPMLERTNNPMAMYSDGPNGVTNESTDTTQQNIP 1263
            AEPSQVQVKPAMNGR   L         +  +TNNPMAMYSDGPNGVTNESTDTTQQNIP
Sbjct: 408  AEPSQVQVKPAMNGRRASL---------IYSKTNNPMAMYSDGPNGVTNESTDTTQQNIP 458

Query: 1264 SVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEK 1443
            SVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEK
Sbjct: 459  SVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEK 518

Query: 1444 QNLHYSSKNEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKI 1623
            QNLHYSSKNEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKI
Sbjct: 519  QNLHYSSKNEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKI 578

Query: 1624 GQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFL 1803
            GQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFL
Sbjct: 579  GQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFL 638

Query: 1804 LLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAE 1983
            LLKAPFLPRQGTT             DSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAE
Sbjct: 639  LLKAPFLPRQGTTELGPLLSSPSELSDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAE 698

Query: 1984 KFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLAD 2163
            KFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLAD
Sbjct: 699  KFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLAD 758

Query: 2164 LCVCRGEANKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSN 2343
            LCVCRGEANKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSN
Sbjct: 759  LCVCRGEANKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSN 818

Query: 2344 SDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPY 2523
            SDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPY
Sbjct: 819  SDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPY 878

Query: 2524 DLRGSFTRLMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGE 2703
            DLRGSFTRLMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGE
Sbjct: 879  DLRGSFTRLMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGE 938

Query: 2704 GIAHKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQ 2883
            GIAHKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQ
Sbjct: 939  GIAHKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQ 998

Query: 2884 NLLAIINEGPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKE 3063
            NLLAIINEGPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKE
Sbjct: 999  NLLAIINEGPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKE 1058

Query: 3064 GRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASE 3243
            GRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASE
Sbjct: 1059 GRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASE 1118

Query: 3244 LYDAIYRSSGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDL 3423
            LYDAIYRSSGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDL
Sbjct: 1119 LYDAIYRSSGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDL 1178

Query: 3424 KQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDL 3603
            KQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDL
Sbjct: 1179 KQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDL 1238

Query: 3604 LDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSD 3783
            LDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSD
Sbjct: 1239 LDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSD 1298

Query: 3784 KAPLIAYPLIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDH 3963
            KAPLIAYPLIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDH
Sbjct: 1299 KAPLIAYPLIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDH 1358

Query: 3964 DMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNN 4143
            DMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNN
Sbjct: 1359 DMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNN 1418

Query: 4144 RELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDE 4323
            RELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDE
Sbjct: 1419 RELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDE 1478

Query: 4324 VRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKC 4503
            VRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKC
Sbjct: 1479 VRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKC 1538

Query: 4504 ASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLED 4683
            ASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLED
Sbjct: 1539 ASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLED 1598

Query: 4684 IRSLRVEKLTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLE 4863
            IRSLRVEKLTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLE
Sbjct: 1599 IRSLRVEKLTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLE 1658

Query: 4864 LTYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQ 5043
            LTYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQ
Sbjct: 1659 LTYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQ 1718

Query: 5044 AASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLH 5223
            AASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLH
Sbjct: 1719 AASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLH 1778

Query: 5224 AAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTL 5403
            AAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTL
Sbjct: 1779 AAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTL 1838

Query: 5404 CKMCDCTKQQLTHQGHRVYNSSVEKGXXXXXXXXXXYFGHHNNHHPPLDRQQSXXXXXXX 5583
            CKMCDCTKQQLTHQGHRVYNSSVEKG          YFGHHNNHHPPLDRQQS
Sbjct: 1839 CKMCDCTKQQLTHQGHRVYNSSVEKGQQLRQLLLQRYFGHHNNHHPPLDRQQSKIGEVIE 1898

Query: 5584 XXXXXXXXTWSQERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGN 5763
                    TWSQERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGN
Sbjct: 1899 AVKEKKEETWSQERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGN 1958

Query: 5764 DKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRLKSDMMSCSDSKPKV---------SS 5916
            DKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRLKSDMMSCSDSKPKV         SS
Sbjct: 1959 DKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRLKSDMMSCSDSKPKVSLSATVSRRSS 2018

Query: 5917 TVLTPLIDAGDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDAL 6096
            TVLTPLIDAGDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDAL
Sbjct: 2019 TVLTPLIDAGDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDAL 2078

Query: 6097 PPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLG 6276
            PPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLG
Sbjct: 2079 PPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLG 2138

Query: 6277 VFGEIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADDH 6456
            VFGEIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADDH
Sbjct: 2139 VFGEIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADDH 2198

Query: 6457 MELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNH 6636
            MELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNH
Sbjct: 2199 MELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNH 2258

Query: 6637 HMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKF 6816
            HMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKF
Sbjct: 2259 HMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKF 2318

Query: 6817 NDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQI 6996
            NDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQI
Sbjct: 2319 NDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQI 2378

Query: 6997 EIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIW 7176
            EIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIW
Sbjct: 2379 EIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIW 2438

Query: 7177 QRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFAV 7356
            QRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFAV
Sbjct: 2439 QRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFAV 2498

Query: 7357 FSSFLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVAF 7536
            FSSFLLAHYLRHDKIYLHKT               IGVTLTLYIFGILQLVNKIVHVVAF
Sbjct: 2499 FSSFLLAHYLRHDKIYLHKTSLLILASLCFLLLSSIGVTLTLYIFGILQLVNKIVHVVAF 2558

Query: 7537 VSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIA 7716
            VSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIA
Sbjct: 2559 VSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIA 2618

Query: 7717 SVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSETCP 7896
            SVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSETCP
Sbjct: 2619 SVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSETCP 2678

Query: 7897 SEGCPGLQPSXXXXXXXXXXXXSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFI 8076
            SEGCPGLQPS            SCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFI
Sbjct: 2679 SEGCPGLQPSEKDDNDDEKKVKSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFI 2738

Query: 8077 WRVAYDMTXXXXXXXXXXXXXXXXXXDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNR 8256
            WRVAYDMT                  DTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNR
Sbjct: 2739 WRVAYDMTFFVVLIVIVLNLIFGVIIDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNR 2798

Query: 8257 SVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQ 8436
            SVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQ
Sbjct: 2799 SVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQ 2858

Query: 8437 DSELDTDQSEVKQMKDQLLQMMTLMREIISQNEESRAFMEQFQPR 8571
            DSELDTDQSEVKQMKDQLLQMMTLMREIISQNEESRAFMEQFQPR
Sbjct: 2859 DSELDTDQSEVKQMKDQLLQMMTLMREIISQNEESRAFMEQFQPR 2903


>gi|14574166|gb|AAK68364.1| Inositol triphosphate receptor protein 1,
            isoform d [Caenorhabditis elegans]
          Length = 2847

 Score = 5469 bits (14187), Expect = 0.0
 Identities = 2744/2855 (96%), Positives = 2746/2855 (96%), Gaps = 9/2855 (0%)
 Frame = +1

Query: 34   RNIGMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIV 213
            R   MALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIV
Sbjct: 2    RKSSMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIV 61

Query: 214  ELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAAD 393
            ELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAAD
Sbjct: 62   ELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAAD 121

Query: 394  KEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNE 573
            KEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNE
Sbjct: 122  KEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNE 181

Query: 574  GSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEV 753
            GSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEV
Sbjct: 182  GSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEV 241

Query: 754  NCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLR 933
            NCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLR
Sbjct: 242  NCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLR 301

Query: 934  MTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKP 1113
            MTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKP
Sbjct: 302  MTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKP 361

Query: 1114 AMNGRPPLLSALSQKSRPMLERTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKS 1293
            AMNGR   L         +  +TNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKS
Sbjct: 362  AMNGRRASL---------IYSKTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKS 412

Query: 1294 EFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNE 1473
            EFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNE
Sbjct: 413  EFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNE 472

Query: 1474 KGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKESIN 1653
            KGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKESIN
Sbjct: 473  KGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKESIN 532

Query: 1654 STTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQ 1833
            STTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQ
Sbjct: 533  STTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQ 592

Query: 1834 GTTXXXXXXXXXXXXXDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIG 2013
            GTT             DSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIG
Sbjct: 593  GTTELGPLLSSPSELSDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIG 652

Query: 2014 FDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEANK 2193
            FDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEANK
Sbjct: 653  FDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEANK 712

Query: 2194 KIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSNSDDAEHLDYY 2373
            KIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSNSDDAEHLDYY
Sbjct: 713  KIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSNSDDAEHLDYY 772

Query: 2374 RHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLM 2553
            RHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLM
Sbjct: 773  RHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLM 832

Query: 2554 LHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATV 2733
            LHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATV
Sbjct: 833  LHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATV 892

Query: 2734 ETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINEGP 2913
            ETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINEGP
Sbjct: 893  ETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINEGP 952

Query: 2914 ATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKTKL 3093
            ATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKTKL
Sbjct: 953  ATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKTKL 1012

Query: 3094 IVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASELYDAIYRSSG 3273
            IVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASELYDAIYRSSG
Sbjct: 1013 IVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASELYDAIYRSSG 1072

Query: 3274 HELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNN 3453
            HELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNN
Sbjct: 1073 HELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNN 1132

Query: 3454 DVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPRA 3633
            DVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPRA
Sbjct: 1133 DVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPRA 1192

Query: 3634 FDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLI 3813
            FDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLI
Sbjct: 1193 FDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLI 1252

Query: 3814 RQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSH 3993
            RQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSH
Sbjct: 1253 RQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSH 1312

Query: 3994 EFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEE 4173
            EFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEE
Sbjct: 1313 EFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEE 1372

Query: 4174 LIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNAS 4353
            LIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNAS
Sbjct: 1373 LIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNAS 1432

Query: 4354 FEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIV 4533
            FEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIV
Sbjct: 1433 FEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIV 1492

Query: 4534 RVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEKLT 4713
            RVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEKLT
Sbjct: 1493 RVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEKLT 1552

Query: 4714 GAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGKLR 4893
            GAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGKLR
Sbjct: 1553 GAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGKLR 1612

Query: 4894 GSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWIGI 5073
            GSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWIGI
Sbjct: 1613 GSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWIGI 1672

Query: 5074 GKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEV 5253
            GKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEV
Sbjct: 1673 GKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEV 1732

Query: 5254 LHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKQQ 5433
            LHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKQQ
Sbjct: 1733 LHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKQQ 1792

Query: 5434 LTHQGHRVYNSSVEKGXXXXXXXXXXYFGHHNNHHPPLDRQQSXXXXXXXXXXXXXXXTW 5613
            LTHQGHRVYNSSVEKG          YFGHHNNHHPPLDRQQS               TW
Sbjct: 1793 LTHQGHRVYNSSVEKGQQLRQLLLQRYFGHHNNHHPPLDRQQSKIGEVIEAVKEKKEETW 1852

Query: 5614 SQERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMR 5793
            SQERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMR
Sbjct: 1853 SQERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMR 1912

Query: 5794 MKQKDIHEPFFKAILTRIQTAQNRLKSDMMSCSDSKPKV---------SSTVLTPLIDAG 5946
            MKQKDIHEPFFKAILTRIQTAQNRLKSDMMSCSDSKPKV         SSTVLTPLIDAG
Sbjct: 1913 MKQKDIHEPFFKAILTRIQTAQNRLKSDMMSCSDSKPKVSLSATVSRRSSTVLTPLIDAG 1972

Query: 5947 DTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPEVALVEPI 6126
            DTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPEVALVEPI
Sbjct: 1973 DTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPEVALVEPI 2032

Query: 6127 LRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFGEIGEHNF 6306
            LRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFGEIGEHNF
Sbjct: 2033 LRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFGEIGEHNF 2092

Query: 6307 SLITQTLATLTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADDHMELALEIKSQ 6486
            SLITQTLATLTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADDHMELALEIKSQ
Sbjct: 2093 SLITQTLATLTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADDHMELALEIKSQ 2152

Query: 6487 ASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDL 6666
            ASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDL
Sbjct: 2153 ASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDL 2212

Query: 6667 FRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDP 6846
            FRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDP
Sbjct: 2213 FRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDP 2272

Query: 6847 REVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTLE 7026
            REVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTLE
Sbjct: 2273 REVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTLE 2332

Query: 7027 RVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWL 7206
            RVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWL
Sbjct: 2333 RVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWL 2392

Query: 7207 SWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFAVFSSFLLAHYL 7386
            SWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFAVFSSFLLAHYL
Sbjct: 2393 SWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFAVFSSFLLAHYL 2452

Query: 7387 RHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRP 7566
            RHDKIYLHKT               IGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRP
Sbjct: 2453 RHDKIYLHKTSLLILASLCFLLLSSIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRP 2512

Query: 7567 IAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIV 7746
            IAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIV
Sbjct: 2513 IAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIV 2572

Query: 7747 WTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSETCPSEGCPGLQPS 7926
            WTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSETCPSEGCPGLQPS
Sbjct: 2573 WTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSETCPSEGCPGLQPS 2632

Query: 7927 XXXXXXXXXXXXSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTXX 8106
                        SCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMT
Sbjct: 2633 EKDDNDDEKKVKSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTFF 2692

Query: 8107 XXXXXXXXXXXXXXXXDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRET 8286
                            DTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRET
Sbjct: 2693 VVLIVIVLNLIFGVIIDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRET 2752

Query: 8287 EHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSE 8466
            EHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSE
Sbjct: 2753 EHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSE 2812

Query: 8467 VKQMKDQLLQMMTLMREIISQNEESRAFMEQFQPR 8571
            VKQMKDQLLQMMTLMREIISQNEESRAFMEQFQPR
Sbjct: 2813 VKQMKDQLLQMMTLMREIISQNEESRAFMEQFQPR 2847


>gi|25153695|ref|NP_501250.2| inositol 1 4 5-Triphosphate Receptor,
            DEfecation Cycle abnormal DEC-4, Let-23 Fertility
            Effector/regulator LFE-1 (330.8 kD) (itr-1)
            [Caenorhabditis elegans]
 gi|5262807|emb|CAB45861.1| inositol 1,4,5-trisphosphate receptor
            [Caenorhabditis elegans]
          Length = 2892

 Score = 5445 bits (14125), Expect = 0.0
 Identities = 2735/2865 (95%), Positives = 2744/2865 (95%), Gaps = 9/2865 (0%)
 Frame = +1

Query: 4    DYDYRRRVLERNIGMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLST 183
            D+D     + R   MALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLST
Sbjct: 48   DFDDFEEQIMRKSSMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLST 107

Query: 184  LGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDD 363
            LGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDD
Sbjct: 108  LGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDD 167

Query: 364  LMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAM 543
            LMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAM
Sbjct: 168  LMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAM 227

Query: 544  KVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFN 723
            KVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFN
Sbjct: 228  KVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFN 287

Query: 724  LLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQ 903
            LLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQ
Sbjct: 288  LLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQ 347

Query: 904  NPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLS 1083
            NPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLS
Sbjct: 348  NPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLS 407

Query: 1084 AEPSQVQVKPAMNGRPPLLSALSQKSRPMLERTNNPMAMYSDGPNGVTNESTDTTQQNIP 1263
            AEPSQVQVKPAMNGR   L         +  +TNNPMAMYSDGPNGVTNESTDTTQQNIP
Sbjct: 408  AEPSQVQVKPAMNGRRASL---------IYSKTNNPMAMYSDGPNGVTNESTDTTQQNIP 458

Query: 1264 SVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEK 1443
            SVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEK
Sbjct: 459  SVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEK 518

Query: 1444 QNLHYSSKNEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKI 1623
            QNLHYSSKNEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKI
Sbjct: 519  QNLHYSSKNEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKI 578

Query: 1624 GQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFL 1803
            GQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFL
Sbjct: 579  GQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFL 638

Query: 1804 LLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAE 1983
            LLKAPFLPRQGTT             DSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAE
Sbjct: 639  LLKAPFLPRQGTTELGPLLSSPSELSDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAE 698

Query: 1984 KFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLAD 2163
            KFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLAD
Sbjct: 699  KFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLAD 758

Query: 2164 LCVCRGEANKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSN 2343
            LCVCRGEANKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSN
Sbjct: 759  LCVCRGEANKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSN 818

Query: 2344 SDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPY 2523
            SDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPY
Sbjct: 819  SDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPY 878

Query: 2524 DLRGSFTRLMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGE 2703
            DLRGSFTRLMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGE
Sbjct: 879  DLRGSFTRLMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGE 938

Query: 2704 GIAHKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQ 2883
            GIAHKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQ
Sbjct: 939  GIAHKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQ 998

Query: 2884 NLLAIINEGPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKE 3063
            NLLAIINEGPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKE
Sbjct: 999  NLLAIINEGPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKE 1058

Query: 3064 GRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASE 3243
            GRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASE
Sbjct: 1059 GRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASE 1118

Query: 3244 LYDAIYRSSGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDL 3423
            LYDAIYRSSGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDL
Sbjct: 1119 LYDAIYRSSGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDL 1178

Query: 3424 KQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDL 3603
            KQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDL
Sbjct: 1179 KQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDL 1238

Query: 3604 LDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSD 3783
            LDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSD
Sbjct: 1239 LDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSD 1298

Query: 3784 KAPLIAYPLIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDH 3963
            KAPLIAYPLIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDH
Sbjct: 1299 KAPLIAYPLIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDH 1358

Query: 3964 DMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNN 4143
            DMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNN
Sbjct: 1359 DMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNN 1418

Query: 4144 RELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDE 4323
            RELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDE
Sbjct: 1419 RELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDE 1478

Query: 4324 VRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKC 4503
            VRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKC
Sbjct: 1479 VRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKC 1538

Query: 4504 ASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLED 4683
            ASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLED
Sbjct: 1539 ASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLED 1598

Query: 4684 IRSLRVEKLTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLE 4863
            IRSLRVEKLTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLE
Sbjct: 1599 IRSLRVEKLTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLE 1658

Query: 4864 LTYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQ 5043
            LTYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQ
Sbjct: 1659 LTYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQ 1718

Query: 5044 AASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLH 5223
            AASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLH
Sbjct: 1719 AASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLH 1778

Query: 5224 AAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTL 5403
            AAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTL
Sbjct: 1779 AAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTL 1838

Query: 5404 CKMCDCTKQQLTHQGHRVYNSSVEKGXXXXXXXXXXYFGHHNNHHPPLDRQQSXXXXXXX 5583
            CKMCDCTKQQLTHQG ++    +++           YFGHHNNHHPPLDRQQS
Sbjct: 1839 CKMCDCTKQQLTHQGQQLRQLLLQR-----------YFGHHNNHHPPLDRQQSKIGEVIE 1887

Query: 5584 XXXXXXXXTWSQERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGN 5763
                    TWSQERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGN
Sbjct: 1888 AVKEKKEETWSQERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGN 1947

Query: 5764 DKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRLKSDMMSCSDSKPKV---------SS 5916
            DKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRLKSDMMSCSDSKPKV         SS
Sbjct: 1948 DKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRLKSDMMSCSDSKPKVSLSATVSRRSS 2007

Query: 5917 TVLTPLIDAGDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDAL 6096
            TVLTPLIDAGDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDAL
Sbjct: 2008 TVLTPLIDAGDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDAL 2067

Query: 6097 PPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLG 6276
            PPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLG
Sbjct: 2068 PPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLG 2127

Query: 6277 VFGEIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADDH 6456
            VFGEIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADDH
Sbjct: 2128 VFGEIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADDH 2187

Query: 6457 MELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNH 6636
            MELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNH
Sbjct: 2188 MELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNH 2247

Query: 6637 HMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKF 6816
            HMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKF
Sbjct: 2248 HMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKF 2307

Query: 6817 NDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQI 6996
            NDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQI
Sbjct: 2308 NDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQI 2367

Query: 6997 EIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIW 7176
            EIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIW
Sbjct: 2368 EIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIW 2427

Query: 7177 QRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFAV 7356
            QRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFAV
Sbjct: 2428 QRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFAV 2487

Query: 7357 FSSFLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVAF 7536
            FSSFLLAHYLRHDKIYLHKT               IGVTLTLYIFGILQLVNKIVHVVAF
Sbjct: 2488 FSSFLLAHYLRHDKIYLHKTSLLILASLCFLLLSSIGVTLTLYIFGILQLVNKIVHVVAF 2547

Query: 7537 VSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIA 7716
            VSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIA
Sbjct: 2548 VSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIA 2607

Query: 7717 SVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSETCP 7896
            SVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSETCP
Sbjct: 2608 SVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSETCP 2667

Query: 7897 SEGCPGLQPSXXXXXXXXXXXXSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFI 8076
            SEGCPGLQPS            SCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFI
Sbjct: 2668 SEGCPGLQPSEKDDNDDEKKVKSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFI 2727

Query: 8077 WRVAYDMTXXXXXXXXXXXXXXXXXXDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNR 8256
            WRVAYDMT                  DTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNR
Sbjct: 2728 WRVAYDMTFFVVLIVIVLNLIFGVIIDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNR 2787

Query: 8257 SVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQ 8436
            SVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQ
Sbjct: 2788 SVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQ 2847

Query: 8437 DSELDTDQSEVKQMKDQLLQMMTLMREIISQNEESRAFMEQFQPR 8571
            DSELDTDQSEVKQMKDQLLQMMTLMREIISQNEESRAFMEQFQPR
Sbjct: 2848 DSELDTDQSEVKQMKDQLLQMMTLMREIISQNEESRAFMEQFQPR 2892


>gi|25153698|ref|NP_501251.2| inositol 1 4 5-Triphosphate Receptor,
            DEfecation Cycle abnormal DEC-4, Let-23 Fertility
            Effector/regulator LFE-1 (324.6 kD) (itr-1)
            [Caenorhabditis elegans]
 gi|5262809|emb|CAB45862.1| inositol 1,4,5-trisphosphate receptor
            [Caenorhabditis elegans]
          Length = 2836

 Score = 5442 bits (14118), Expect = 0.0
 Identities = 2733/2855 (95%), Positives = 2740/2855 (95%), Gaps = 9/2855 (0%)
 Frame = +1

Query: 34   RNIGMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIV 213
            R   MALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIV
Sbjct: 2    RKSSMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIV 61

Query: 214  ELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAAD 393
            ELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAAD
Sbjct: 62   ELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAAD 121

Query: 394  KEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNE 573
            KEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNE
Sbjct: 122  KEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNE 181

Query: 574  GSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEV 753
            GSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEV
Sbjct: 182  GSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEV 241

Query: 754  NCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLR 933
            NCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLR
Sbjct: 242  NCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLR 301

Query: 934  MTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKP 1113
            MTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKP
Sbjct: 302  MTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKP 361

Query: 1114 AMNGRPPLLSALSQKSRPMLERTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKS 1293
            AMNGR   L         +  +TNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKS
Sbjct: 362  AMNGRRASL---------IYSKTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKS 412

Query: 1294 EFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNE 1473
            EFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNE
Sbjct: 413  EFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNE 472

Query: 1474 KGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKESIN 1653
            KGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKESIN
Sbjct: 473  KGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKESIN 532

Query: 1654 STTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQ 1833
            STTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQ
Sbjct: 533  STTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQ 592

Query: 1834 GTTXXXXXXXXXXXXXDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIG 2013
            GTT             DSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIG
Sbjct: 593  GTTELGPLLSSPSELSDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIG 652

Query: 2014 FDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEANK 2193
            FDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEANK
Sbjct: 653  FDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEANK 712

Query: 2194 KIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSNSDDAEHLDYY 2373
            KIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSNSDDAEHLDYY
Sbjct: 713  KIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSNSDDAEHLDYY 772

Query: 2374 RHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLM 2553
            RHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLM
Sbjct: 773  RHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLM 832

Query: 2554 LHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATV 2733
            LHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATV
Sbjct: 833  LHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATV 892

Query: 2734 ETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINEGP 2913
            ETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINEGP
Sbjct: 893  ETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINEGP 952

Query: 2914 ATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKTKL 3093
            ATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKTKL
Sbjct: 953  ATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKTKL 1012

Query: 3094 IVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASELYDAIYRSSG 3273
            IVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASELYDAIYRSSG
Sbjct: 1013 IVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASELYDAIYRSSG 1072

Query: 3274 HELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNN 3453
            HELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNN
Sbjct: 1073 HELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNN 1132

Query: 3454 DVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPRA 3633
            DVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPRA
Sbjct: 1133 DVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPRA 1192

Query: 3634 FDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLI 3813
            FDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLI
Sbjct: 1193 FDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLI 1252

Query: 3814 RQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSH 3993
            RQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSH
Sbjct: 1253 RQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSH 1312

Query: 3994 EFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEE 4173
            EFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEE
Sbjct: 1313 EFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEE 1372

Query: 4174 LIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNAS 4353
            LIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNAS
Sbjct: 1373 LIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNAS 1432

Query: 4354 FEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIV 4533
            FEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIV
Sbjct: 1433 FEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIV 1492

Query: 4534 RVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEKLT 4713
            RVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEKLT
Sbjct: 1493 RVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEKLT 1552

Query: 4714 GAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGKLR 4893
            GAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGKLR
Sbjct: 1553 GAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGKLR 1612

Query: 4894 GSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWIGI 5073
            GSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWIGI
Sbjct: 1613 GSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWIGI 1672

Query: 5074 GKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEV 5253
            GKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEV
Sbjct: 1673 GKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEV 1732

Query: 5254 LHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKQQ 5433
            LHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKQQ
Sbjct: 1733 LHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKQQ 1792

Query: 5434 LTHQGHRVYNSSVEKGXXXXXXXXXXYFGHHNNHHPPLDRQQSXXXXXXXXXXXXXXXTW 5613
            LTHQG ++    +++           YFGHHNNHHPPLDRQQS               TW
Sbjct: 1793 LTHQGQQLRQLLLQR-----------YFGHHNNHHPPLDRQQSKIGEVIEAVKEKKEETW 1841

Query: 5614 SQERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMR 5793
            SQERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMR
Sbjct: 1842 SQERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMR 1901

Query: 5794 MKQKDIHEPFFKAILTRIQTAQNRLKSDMMSCSDSKPKV---------SSTVLTPLIDAG 5946
            MKQKDIHEPFFKAILTRIQTAQNRLKSDMMSCSDSKPKV         SSTVLTPLIDAG
Sbjct: 1902 MKQKDIHEPFFKAILTRIQTAQNRLKSDMMSCSDSKPKVSLSATVSRRSSTVLTPLIDAG 1961

Query: 5947 DTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPEVALVEPI 6126
            DTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPEVALVEPI
Sbjct: 1962 DTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPEVALVEPI 2021

Query: 6127 LRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFGEIGEHNF 6306
            LRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFGEIGEHNF
Sbjct: 2022 LRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFGEIGEHNF 2081

Query: 6307 SLITQTLATLTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADDHMELALEIKSQ 6486
            SLITQTLATLTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADDHMELALEIKSQ
Sbjct: 2082 SLITQTLATLTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADDHMELALEIKSQ 2141

Query: 6487 ASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDL 6666
            ASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDL
Sbjct: 2142 ASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDL 2201

Query: 6667 FRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDP 6846
            FRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDP
Sbjct: 2202 FRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDP 2261

Query: 6847 REVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTLE 7026
            REVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTLE
Sbjct: 2262 REVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTLE 2321

Query: 7027 RVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWL 7206
            RVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWL
Sbjct: 2322 RVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWL 2381

Query: 7207 SWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFAVFSSFLLAHYL 7386
            SWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFAVFSSFLLAHYL
Sbjct: 2382 SWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFAVFSSFLLAHYL 2441

Query: 7387 RHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRP 7566
            RHDKIYLHKT               IGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRP
Sbjct: 2442 RHDKIYLHKTSLLILASLCFLLLSSIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRP 2501

Query: 7567 IAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIV 7746
            IAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIV
Sbjct: 2502 IAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIV 2561

Query: 7747 WTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSETCPSEGCPGLQPS 7926
            WTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSETCPSEGCPGLQPS
Sbjct: 2562 WTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSETCPSEGCPGLQPS 2621

Query: 7927 XXXXXXXXXXXXSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTXX 8106
                        SCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMT
Sbjct: 2622 EKDDNDDEKKVKSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTFF 2681

Query: 8107 XXXXXXXXXXXXXXXXDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRET 8286
                            DTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRET
Sbjct: 2682 VVLIVIVLNLIFGVIIDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRET 2741

Query: 8287 EHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSE 8466
            EHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSE
Sbjct: 2742 EHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSE 2801

Query: 8467 VKQMKDQLLQMMTLMREIISQNEESRAFMEQFQPR 8571
            VKQMKDQLLQMMTLMREIISQNEESRAFMEQFQPR
Sbjct: 2802 VKQMKDQLLQMMTLMREIISQNEESRAFMEQFQPR 2836


>gi|10636263|emb|CAC10528.1| putative inositol 1,4,5-trisphosphate
            receptor [Caenorhabditis briggsae]
          Length = 2933

 Score = 4970 bits (12892), Expect = 0.0
 Identities = 2488/2886 (86%), Positives = 2622/2886 (90%), Gaps = 30/2886 (1%)
 Frame = +1

Query: 4    DYDYRRRVLERNIGMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLST 183
            D+D     + R   M LPSRKLTIA+SIDHGNNGNLHIGDIISLYTESS+NQEQRGFLST
Sbjct: 55   DFDDFEEQIMRKSSMNLPSRKLTIASSIDHGNNGNLHIGDIISLYTESSTNQEQRGFLST 114

Query: 184  LGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDD 363
            LGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDD
Sbjct: 115  LGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDD 174

Query: 364  LMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAM 543
            LMNKL+VAA+KEREENE+EFQKTLGN+IQYGSMVQLLHVKSNKYITVQKNSPAKRERNAM
Sbjct: 175  LMNKLRVAAEKEREENEAEFQKTLGNIIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAM 234

Query: 544  KVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFN 723
            KVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPN+VSTTQ GHVKSQLHLS  N
Sbjct: 235  KVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNAVSTTQTGHVKSQLHLSGLN 294

Query: 724  LLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQ 903
            LLDHQ+AAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPK
Sbjct: 295  LLDHQTAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKT 354

Query: 904  NPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLS 1083
            NPP DVVFLRMTNRPSAADATSSRALWEVQVVQ+NAYRGGTAKWNK YRFKHLA+DMYL+
Sbjct: 355  NPPKDVVFLRMTNRPSAADATSSRALWEVQVVQSNAYRGGTAKWNKTYRFKHLASDMYLT 414

Query: 1084 AEPSQVQVKPAMNGRPPLLSALSQKSRPMLERTNNPMA-MYSDGPNGVTNESTDTTQQNI 1260
             E SQ++ KPAMNGRPPLLS LSQKS+ +LERT +P+A MYSDGPNG  N+++D +
Sbjct: 415  VEESQMKAKPAMNGRPPLLSTLSQKSK-ILERTQSPLASMYSDGPNG-GNDTSDASDG-- 470

Query: 1261 PSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATE 1440
            P+V  L P KS+FPE+D  LLF+LDPSTFMKSNKEVPRRSYVRLLH  +  WVHATNA E
Sbjct: 471  PTVSFLSPKKSDFPEDDIKLLFELDPSTFMKSNKEVPRRSYVRLLHHKTASWVHATNANE 530

Query: 1441 KQNLHYSSKNEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIK 1620
            KQNLH+S+KNEKGWVKVICE +RVDKETFALLPVNPDEVRDLDFANDACK LRNFI LIK
Sbjct: 531  KQNLHFSNKNEKGWVKVICETHRVDKETFALLPVNPDEVRDLDFANDACKXLRNFINLIK 590

Query: 1621 IGQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVF 1800
            IG VISKES+NSTTQLLIDCILFVTNSSDHLADPLKI+DFSPSRDRQKLLRE+EVL+QVF
Sbjct: 591  IGSVISKESLNSTTQLLIDCILFVTNSSDHLADPLKITDFSPSRDRQKLLREEEVLHQVF 650

Query: 1801 LLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLA 1980
            LLLKAPF PRQG+T             DSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLA
Sbjct: 651  LLLKAPFQPRQGSTELGPLLGSPADLSDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLA 710

Query: 1981 EKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLA 2160
            EKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVK PHVERFV+LVRNNRQGKFLDYLA
Sbjct: 711  EKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKAPHVERFVDLVRNNRQGKFLDYLA 770

Query: 2161 DLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKS 2340
            DLCVCRGEANKKIQELICTSVLS KHRDIFMDTK+I+GE+E+GW PNFRKLVDIAEGAKS
Sbjct: 771  DLCVCRGEANKKIQELICTSVLSDKHRDIFMDTKVINGEVEIGWDPNFRKLVDIAEGAKS 830

Query: 2341 NSDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLP 2520
            N DD EHLDYYRHQLDLLSQMCQEQQYLAIDPP ER LMNISQQLPAELVLQCMSD RLP
Sbjct: 831  NHDDVEHLDYYRHQLDLLSQMCQEQQYLAIDPPVERGLMNISQQLPAELVLQCMSDTRLP 890

Query: 2521 YDLRGSFTRLMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIG 2700
            YDLRGSFTRLMLHLHVVRGSPMSAIRHARLW SIPE+VNVSTYESVSVEAYSDGSRMRIG
Sbjct: 891  YDLRGSFTRLMLHLHVVRGSPMSAIRHARLWRSIPESVNVSTYESVSVEAYSDGSRMRIG 950

Query: 2701 EGIAHKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLT 2880
              IAHKVLATVETYLMGLR+Q  +ER SVNSSKLTYEIVNLAK+LAQFNFYSFN+LLQLT
Sbjct: 951  ASIAHKVLATVETYLMGLRDQPTDERHSVNSSKLTYEIVNLAKSLAQFNFYSFNELLQLT 1010

Query: 2881 QNLLAIINEGPATEQVPSHRAMVNAIRNMSKSMMRGGN-KENSKDLAKTPSVTAEEAGRT 3057
            +NLLAIINEGP  EQVPSH+AMVN IRNMSKSM+RGGN KENSKDLAKTPS++ ++AGR+
Sbjct: 1011 KNLLAIINEGPVPEQVPSHQAMVNVIRNMSKSMLRGGNNKENSKDLAKTPSMSTDDAGRS 1070

Query: 3058 KEGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMA 3237
            KEGRAL VKTKLIVAEILQFVMDVRRDYRITMALSWFKN FPCDEDGSLMHSASINE+MA
Sbjct: 1071 KEGRALIVKTKLIVAEILQFVMDVRRDYRITMALSWFKNEFPCDEDGSLMHSASINEKMA 1130

Query: 3238 SELYDAIYRSSGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLE 3417
            SELYDAIY SSGHELHLDG+DGQLLLAILLQMTMSDYPPLTSIALKV FRHFTQYQELLE
Sbjct: 1131 SELYDAIYHSSGHELHLDGKDGQLLLAILLQMTMSDYPPLTSIALKVLFRHFTQYQELLE 1190

Query: 3418 DLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEH 3597
            DLKQVQLLVSN+DVENYRQIDRDLFILKNLTEKSELWVHGDR+HS++TKEV++KE+TTE+
Sbjct: 1191 DLKQVQLLVSNDDVENYRQIDRDLFILKNLTEKSELWVHGDRNHSVETKEVEDKEKTTEY 1250

Query: 3598 DLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQEL 3777
            DL  H L +PRAF+S DSM+A++AV+NEHY + +NE LQLLNRLLI DDRND AVALQEL
Sbjct: 1251 DLHMHQLNTPRAFESRDSMDAVIAVINEHYSNFKNESLQLLNRLLINDDRNDEAVALQEL 1310

Query: 3778 SDKAPLIAYPLIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKH 3957
            SDKAPLIAYPLIRQMLVRL  MCYR G  KPDTMNQQLLKNMRVYEVVLEFISVPHDKKH
Sbjct: 1311 SDKAPLIAYPLIRQMLVRLKRMCYRDG--KPDTMNQQLLKNMRVYEVVLEFISVPHDKKH 1368

Query: 3958 DHDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFR 4137
            DH+MMKLITLSHEFLR FCK NKENQSRLYKFISYEKDAKEGMLRVET+EEVGTLVAIFR
Sbjct: 1369 DHEMMKLITLSHEFLRDFCKANKENQSRLYKFISYEKDAKEGMLRVETVEEVGTLVAIFR 1428

Query: 4138 NNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAAS 4317
            NNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAAS
Sbjct: 1429 NNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAAS 1488

Query: 4318 DEVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTEL 4497
            DEVRQLYVDNASFEELEAMMK EKES+GR ++SR+ LKYHIELVRLLAMCTRGKNGNTEL
Sbjct: 1489 DEVRQLYVDNASFEELEAMMKQEKESRGRETESRKPLKYHIELVRLLAMCTRGKNGNTEL 1548

Query: 4498 KCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLL 4677
            KCASQIPMDHIVRVVT+K CLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVD+ILNNLL
Sbjct: 1549 KCASQIPMDHIVRVVTSKHCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDNILNNLL 1608

Query: 4678 EDIRSLRVEKLTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVL 4857
            EDIRSLR+++LT AET  LEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVL
Sbjct: 1609 EDIRSLRIDRLTDAETVALEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVL 1668

Query: 4858 LELTYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKW 5037
            LELT LE+GKL+ ++SSRNWYRVAECIKRLTKWAEEH+I+LPATL GPQMS   +VRQKW
Sbjct: 1669 LELTSLERGKLKSTRSSRNWYRVAECIKRLTKWAEEHSISLPATLVGPQMSATATVRQKW 1728

Query: 5038 QQAASSAKWIGIGK--------RLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIG 5193
            Q AA+SAK IG+ K        RLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIG
Sbjct: 1729 QNAATSAKLIGLNKPVITLVVERLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIG 1788

Query: 5194 EFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQD 5373
            EFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQD
Sbjct: 1789 EFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQD 1848

Query: 5374 NLCARVLQTLCKMCDCTKQQLTHQGHRVYNSSVEKGXXXXXXXXXX-----------YFG 5520
            NLC+RVLQTLCKMCDCTKQQLT QG R YNSS EKG                     YFG
Sbjct: 1849 NLCSRVLQTLCKMCDCTKQQLTQQGRRFYNSSFEKGRRFYNSSFEKGQQLRHLLLQRYFG 1908

Query: 5521 HHNNHHPPLDRQQSXXXXXXXXXXXXXXXTWSQERDLYAIQCKLNDAGASDLVTDIIIME 5700
            HHN+HHPPLDRQQS               TWSQERDLYAIQCKLNDAGASDLV DIIIME
Sbjct: 1909 HHNHHHPPLDRQQSKIGEVVEAVKEKKEETWSQERDLYAIQCKLNDAGASDLVIDIIIME 1968

Query: 5701 PSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRLKSDM 5880
            PSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEPFFK ILTRIQTAQNRLKSDM
Sbjct: 1969 PSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEPFFKVILTRIQTAQNRLKSDM 2028

Query: 5881 MSCSDSKPKVS---------STVLTPLIDAGDTGFNGALFEVPQQVRHPSISEMSQLSND 6033
            MSCSDSKPK S         STVLTPLIDAGDTGFNG LFEVPQQVRHPSISEMSQLSND
Sbjct: 2029 MSCSDSKPKPSLSATVSRRSSTVLTPLIDAGDTGFNGTLFEVPQQVRHPSISEMSQLSND 2088

Query: 6034 LTHSIPDLAPYQDEEKSTDALPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHN 6213
            LTHSIPDL PYQDE+KS DALPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHN
Sbjct: 2089 LTHSIPDLTPYQDEDKSADALPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHN 2148

Query: 6214 LVSETLSFLDTVCGSTKGSLGVFGEIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQE 6393
            LVSETLSFLDTVCGSTKGSLGVFGEIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQE
Sbjct: 2149 LVSETLSFLDTVCGSTKGSLGVFGEIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQE 2208

Query: 6394 NGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMS 6573
            NGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMS
Sbjct: 2209 NGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMS 2268

Query: 6574 GGPKQLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVD 6753
            GGP+QLVHAIKQAYEMT SNHHMLKS+SRDL R+AEDD K KSGPQITVNT+TLPEINVD
Sbjct: 2269 GGPQQLVHAIKQAYEMTRSNHHMLKSVSRDLLRRAEDDSKSKSGPQITVNTITLPEINVD 2328

Query: 6754 ASGIVSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSD 6933
            ASGIVSIHTEK+ISSSLDDKF++DD PSVDPREVGHNIYILAHQLAIHDGELEIWLDGSD
Sbjct: 2329 ASGIVSIHTEKSISSSLDDKFHEDDSPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSD 2388

Query: 6934 EKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDN 7113
            EKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPIN+ICS+LTK+TKDYVYNNTERDN
Sbjct: 2389 EKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPINEICSFLTKETKDYVYNNTERDN 2448

Query: 7114 QGSKVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYY 7293
            QGSKVTEFFD+WETMYHEMIWQRKLQDRKWLSWCA RLPLWTRLSF FAFIVNALVA YY
Sbjct: 2449 QGSKVTEFFDQWETMYHEMIWQRKLQDRKWLSWCAVRLPLWTRLSFQFAFIVNALVALYY 2508

Query: 7294 PLPEHSNSSISLGNLYSWFAVFSSFLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVT 7473
            P PE ++SSIS GNLYSW AV S+FLLAH+LRH+K YL KT               IGV
Sbjct: 2509 PFPESTSSSISFGNLYSWLAVISAFLLAHFLRHEKAYLSKTALLILSSLCFLLVNSIGVN 2568

Query: 7474 LTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPM 7653
            LTLY FG+LQLVNK++HV+AFVSNKGLEDRP++EIL CRNLHYLLVYL +CI G ++HPM
Sbjct: 2569 LTLYFFGMLQLVNKVIHVLAFVSNKGLEDRPLSEILGCRNLHYLLVYLTVCIAGFVIHPM 2628

Query: 7654 IYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEV 7833
            IYC LLFDII TEETLQNVIASVTRNYQSIVWTGLLALILLY FSILGFL+FRHDFYLEV
Sbjct: 2629 IYCALLFDIIATEETLQNVIASVTRNYQSIVWTGLLALILLYIFSILGFLFFRHDFYLEV 2688

Query: 7834 DPVENDSSATISSGIPSETCPSEGCPGLQPSXXXXXXXXXXXXSCETLWMCILQTGYQGL 8013
            DPVE DS A+IS  +P++TCP EGCPGL+              SCETLWMCILQT Y GL
Sbjct: 2689 DPVEPDSPASISGALPTDTCPKEGCPGLE-RTKDNDDDDKKVKSCETLWMCILQTMYLGL 2747

Query: 8014 RNGGGIGDVLRNPAPWEDMFIWRVAYDMTXXXXXXXXXXXXXXXXXXDTFGDLRAEKNEK 8193
            RNGGGIGDVLRNPAPWEDMF+WRVAYDMT                  DTFGDLRAEKNEK
Sbjct: 2748 RNGGGIGDVLRNPAPWEDMFVWRVAYDMTFFVVLIVIVLNLIFGVIIDTFGDLRAEKNEK 2807

Query: 8194 EQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPESYV 8373
            EQILKNNCFICGLDRSRFDNRSVTFE+HRE EHNIWHYLYYIVMLQIKDETEFTGPESYV
Sbjct: 2808 EQILKNNCFICGLDRSRFDNRSVTFESHREMEHNIWHYLYYIVMLQIKDETEFTGPESYV 2867

Query: 8374 AQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLLQMMTLMREIISQNEESRAFM 8553
            AQCVK+RNLDWFPRMQALSLQDSELDTDQSE+KQMKDQ++QMM +MRE  SQ +E RAFM
Sbjct: 2868 AQCVKERNLDWFPRMQALSLQDSELDTDQSEMKQMKDQMMQMMAMMRENQSQWDEVRAFM 2927

Query: 8554 EQFQPR 8571
            EQ Q R
Sbjct: 2928 EQLQSR 2933


>gi|39593648|emb|CAE61940.1| Hypothetical protein CBG05938
            [Caenorhabditis briggsae]
          Length = 2841

 Score = 4953 bits (12848), Expect = 0.0
 Identities = 2477/2868 (86%), Positives = 2615/2868 (90%), Gaps = 11/2868 (0%)
 Frame = +1

Query: 1    MDYDYRRRVLERNIGMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLS 180
            M+ DYRRRVL+R IGM LPSRKLTIA+SIDHGNNGNLHIGDIISLYTESS+NQEQRGFLS
Sbjct: 1    MELDYRRRVLDRTIGMNLPSRKLTIASSIDHGNNGNLHIGDIISLYTESSTNQEQRGFLS 60

Query: 181  TLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDD 360
            TLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDD
Sbjct: 61   TLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDD 120

Query: 361  DLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNA 540
            DLMNKL+VAA+KEREENE+EFQKTLGN+IQYGSMVQLLHVKSNKYITVQKNSPAKRERNA
Sbjct: 121  DLMNKLRVAAEKEREENEAEFQKTLGNIIQYGSMVQLLHVKSNKYITVQKNSPAKRERNA 180

Query: 541  MKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSF 720
            MKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPN+VSTTQ GHVKSQLHLS
Sbjct: 181  MKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNAVSTTQTGHVKSQLHLSGL 240

Query: 721  NLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPK 900
            NLLDHQ+AAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPK
Sbjct: 241  NLLDHQTAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPK 300

Query: 901  QNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYL 1080
             NPP DVVFLRMTNRPSAADATSSRALWEVQVVQ+NAYRGGTAKWNK YRFKHLA+DMYL
Sbjct: 301  TNPPKDVVFLRMTNRPSAADATSSRALWEVQVVQSNAYRGGTAKWNKTYRFKHLASDMYL 360

Query: 1081 SAEPSQVQVKPAMNGRPPLLSALSQKSRPMLERTNNPMA-MYSDGPNGVTNESTDTTQQN 1257
            + E SQ++ KPAMNGR   L         +  +T +P+A MYSDGPNG  N+++D +
Sbjct: 361  TVEESQMKAKPAMNGRRASL---------IHSKTQSPLASMYSDGPNG-GNDTSDASDG- 409

Query: 1258 IPSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNAT 1437
             P+V  L P KS+FPE+D  LLF+LDPSTFMKSNKEVPRRSYVRLLH  +  WVHATNA
Sbjct: 410  -PTVSFLSPKKSDFPEDDIKLLFELDPSTFMKSNKEVPRRSYVRLLHHKTASWVHATNAN 468

Query: 1438 EKQNLHYSSKNEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLI 1617
            EKQNLH+S+KNEKGWVKVICE +RVDKETFALLPVNPDEVRDLDFANDACKALRNFI LI
Sbjct: 469  EKQNLHFSNKNEKGWVKVICETHRVDKETFALLPVNPDEVRDLDFANDACKALRNFINLI 528

Query: 1618 KIGQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQV 1797
            KIG VISKES+NSTTQLLIDCILFVTNSSDHLADPLKI+DFSPSRDRQKLLREQEVL+QV
Sbjct: 529  KIGSVISKESLNSTTQLLIDCILFVTNSSDHLADPLKITDFSPSRDRQKLLREQEVLHQV 588

Query: 1798 FLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFL 1977
            FLLLKAPF PRQG+T             DSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFL
Sbjct: 589  FLLLKAPFQPRQGSTELGPLLGSPADLSDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFL 648

Query: 1978 AEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYL 2157
            AEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVK PHVERFV+LVRNNRQGKFLDYL
Sbjct: 649  AEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKAPHVERFVDLVRNNRQGKFLDYL 708

Query: 2158 ADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAK 2337
            ADLCVCRGEANKKIQELICTSVLS KHRDIFMDTK+I+GE+E+GW PNFRKLVDIAEGAK
Sbjct: 709  ADLCVCRGEANKKIQELICTSVLSDKHRDIFMDTKVINGEVEIGWDPNFRKLVDIAEGAK 768

Query: 2338 SNSDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRL 2517
            SN DD EHLDYYRHQLDLLSQMCQEQQYLAIDPP ER LMNISQQLPAELVLQCMSD RL
Sbjct: 769  SNHDDVEHLDYYRHQLDLLSQMCQEQQYLAIDPPVERGLMNISQQLPAELVLQCMSDTRL 828

Query: 2518 PYDLRGSFTRLMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRI 2697
            PYDLRGSFTRLMLHLHVVRGSPMSAIRHARLW SIPE+VNVSTYESVSVEAYSDGSRMRI
Sbjct: 829  PYDLRGSFTRLMLHLHVVRGSPMSAIRHARLWRSIPESVNVSTYESVSVEAYSDGSRMRI 888

Query: 2698 GEGIAHKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQL 2877
            G  IAHKVLATVETYLMGLR+Q  +ER SVNSSKLTYEIVNLAK+LAQFNFYSFN+LLQL
Sbjct: 889  GASIAHKVLATVETYLMGLRDQPTDERHSVNSSKLTYEIVNLAKSLAQFNFYSFNELLQL 948

Query: 2878 TQNLLAIINEGPATEQVPSHRAMVNAIRNMSKSMMRGGN-KENSKDLAKTPSVTAEEAGR 3054
            T+NLLAIINEGP  EQVPSH+AMVN IRNMSKSM+RGGN KENSKDLAKTPS++ ++AGR
Sbjct: 949  TKNLLAIINEGPVPEQVPSHQAMVNVIRNMSKSMLRGGNNKENSKDLAKTPSMSTDDAGR 1008

Query: 3055 TKEGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERM 3234
            +KEGRAL VKTKLIVAEILQFVMDVRRDYRITMALSWFKN FPCDEDGSLMHSASINE+M
Sbjct: 1009 SKEGRALIVKTKLIVAEILQFVMDVRRDYRITMALSWFKNEFPCDEDGSLMHSASINEKM 1068

Query: 3235 ASELYDAIYRSSGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELL 3414
            ASELYDAIY SSGHELHLDG+DGQLLLAILLQMTMSDYPPLTSIALKV FRHFTQYQELL
Sbjct: 1069 ASELYDAIYHSSGHELHLDGKDGQLLLAILLQMTMSDYPPLTSIALKVLFRHFTQYQELL 1128

Query: 3415 EDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTE 3594
            EDLKQVQLLVSN+DVENYRQIDRDLFILKNLTEKSELWVHGDR+HS++TKEV++KE+TTE
Sbjct: 1129 EDLKQVQLLVSNDDVENYRQIDRDLFILKNLTEKSELWVHGDRNHSVETKEVEDKEKTTE 1188

Query: 3595 HDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQE 3774
            +DL  H L +PRAF+S DSM+A++AV+NEHY + +NE LQLLNRLLI DDRND AVALQE
Sbjct: 1189 YDLHMHQLNTPRAFESRDSMDAVIAVINEHYSNFKNESLQLLNRLLINDDRNDEAVALQE 1248

Query: 3775 LSDKAPLIAYPLIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKK 3954
            LSDKAPLIAYPLIRQMLVRL  MCYR G  KPDTMNQQLLKNMRVYEVVLEFISVPHDKK
Sbjct: 1249 LSDKAPLIAYPLIRQMLVRLKRMCYRDG--KPDTMNQQLLKNMRVYEVVLEFISVPHDKK 1306

Query: 3955 HDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIF 4134
            HDH+MMKLITLSHEFLR FCK NKENQSRLYKFISYEKDAKEGMLRVET+EEVGTLVAIF
Sbjct: 1307 HDHEMMKLITLSHEFLRDFCKANKENQSRLYKFISYEKDAKEGMLRVETVEEVGTLVAIF 1366

Query: 4135 RNNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAA 4314
            RNNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAA
Sbjct: 1367 RNNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAA 1426

Query: 4315 SDEVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTE 4494
            SDEVRQLYVDNASFEELEAMMK EKES+GR ++SR+ LKYHIELVRLLAMCTRGKNGNTE
Sbjct: 1427 SDEVRQLYVDNASFEELEAMMKQEKESRGRETESRKPLKYHIELVRLLAMCTRGKNGNTE 1486

Query: 4495 LKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNL 4674
            LKCASQIPMDHIVRVVT+K CLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVD+ILNNL
Sbjct: 1487 LKCASQIPMDHIVRVVTSKHCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDNILNNL 1546

Query: 4675 LEDIRSLRVEKLTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEV 4854
            LEDIRSLR+++LT AET  LEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEV
Sbjct: 1547 LEDIRSLRIDRLTDAETVALEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEV 1606

Query: 4855 LLELTYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQK 5034
            LLELT LE+GKL+ ++SSRNWYRVAECIKRLTKWAEEH I+LPATL GPQMS   +VRQK
Sbjct: 1607 LLELTSLERGKLKSTRSSRNWYRVAECIKRLTKWAEEH-ISLPATLVGPQMSATATVRQK 1665

Query: 5035 WQQAASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLH 5214
            WQ AA+SAK IG+ KRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLH
Sbjct: 1666 WQNAATSAKLIGLNKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLH 1725

Query: 5215 PLHAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVL 5394
            PLHAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLC+RVL
Sbjct: 1726 PLHAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCSRVL 1785

Query: 5395 QTLCKMCDCTKQQLTHQGHRVYNSSVEKGXXXXXXXXXXYFGHHNNHHPPLDRQQSXXXX 5574
            QTLCKMCDCTKQQLT QG ++ +  +++           YFGHHN+HHPPLDRQQS
Sbjct: 1786 QTLCKMCDCTKQQLTQQGQQLRHLLLQR-----------YFGHHNHHHPPLDRQQSKIGE 1834

Query: 5575 XXXXXXXXXXXTWSQERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLH 5754
                       TWSQERDLYAIQCKLNDAGASDLV DIIIMEPSREIFLKAIHLARALLH
Sbjct: 1835 VVEAVKEKKEETWSQERDLYAIQCKLNDAGASDLVIDIIIMEPSREIFLKAIHLARALLH 1894

Query: 5755 EGNDKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRLKSDMMSCSDSKPKVS------- 5913
            EGNDKVQHSFYMRMKQKDIHEPFFK ILTRIQTAQNRLKSDMMSCSDSKPK S
Sbjct: 1895 EGNDKVQHSFYMRMKQKDIHEPFFKVILTRIQTAQNRLKSDMMSCSDSKPKPSLSATVSR 1954

Query: 5914 --STVLTPLIDAGDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKST 6087
              STVLTPLIDAGDTGFNG LFEVPQQVRHPSISEMSQLSNDLTHSIPDL PYQDE+KS
Sbjct: 1955 RSSTVLTPLIDAGDTGFNGTLFEVPQQVRHPSISEMSQLSNDLTHSIPDLTPYQDEDKSA 2014

Query: 6088 DALPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKG 6267
            DALPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKG
Sbjct: 2015 DALPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKG 2074

Query: 6268 SLGVFGEIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLA 6447
            SLGVFGEIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLA
Sbjct: 2075 SLGVFGEIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLA 2134

Query: 6448 DDHMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTN 6627
            DDHMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMT
Sbjct: 2135 DDHMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTR 2194

Query: 6628 SNHHMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLD 6807
            SNHHMLKS+SRDL R+AEDD K KSGPQITVNT+TLPEINVDASGIVSIHTEK+ISSSLD
Sbjct: 2195 SNHHMLKSVSRDLLRRAEDDSKSKSGPQITVNTITLPEINVDASGIVSIHTEKSISSSLD 2254

Query: 6808 DKFNDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERT 6987
            DKF++DD PSVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERT
Sbjct: 2255 DKFHEDDSPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERT 2314

Query: 6988 AQIEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHE 7167
            AQIEIVRRDRTLERVVFPIN+ICS+LTK+TKDYVYNNTERDNQGSKVTEFFD+WETMYHE
Sbjct: 2315 AQIEIVRRDRTLERVVFPINEICSFLTKETKDYVYNNTERDNQGSKVTEFFDQWETMYHE 2374

Query: 7168 MIWQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSW 7347
            MIWQRKLQDRKWLSWCA RLPLWTRLSF FAFIVNALVA YYP PE ++SSIS GNLYSW
Sbjct: 2375 MIWQRKLQDRKWLSWCAVRLPLWTRLSFQFAFIVNALVALYYPFPESTSSSISFGNLYSW 2434

Query: 7348 FAVFSSFLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHV 7527
             AV S+FLLAH+LRH+K YL KT               IGV LTLY FG+LQ +NK++HV
Sbjct: 2435 LAVISAFLLAHFLRHEKAYLSKTALLILSSLCFLLVNSIGVNLTLYFFGMLQAINKVIHV 2494

Query: 7528 VAFVSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQN 7707
            +AFVSNKGLEDRP++EIL CRNLHYLLVYL +CI G ++HPMIYC LLFDII TEETLQN
Sbjct: 2495 LAFVSNKGLEDRPLSEILGCRNLHYLLVYLTVCIAGFVIHPMIYCALLFDIIATEETLQN 2554

Query: 7708 VIASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSE 7887
            VIASVTRNYQSIVWTGLLALILLY FSILGFL+FRHDFYLEVDPVE DS A+IS  +P++
Sbjct: 2555 VIASVTRNYQSIVWTGLLALILLYIFSILGFLFFRHDFYLEVDPVEPDSPASISGALPTD 2614

Query: 7888 TCPSEGCPGLQPSXXXXXXXXXXXXSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWED 8067
            TCP EGCPGL+              SCETLWMCILQT Y GLRNGGGIGDVLRNPAPWED
Sbjct: 2615 TCPKEGCPGLE-RTKDNDDDDKKVKSCETLWMCILQTMYLGLRNGGGIGDVLRNPAPWED 2673

Query: 8068 MFIWRVAYDMTXXXXXXXXXXXXXXXXXXDTFGDLRAEKNEKEQILKNNCFICGLDRSRF 8247
            MF+WRVAYDMT                  DTFGDLRAEKNEKEQILKNNCFICGLDRSRF
Sbjct: 2674 MFVWRVAYDMTFFVVLIVIVLNLIFGVIIDTFGDLRAEKNEKEQILKNNCFICGLDRSRF 2733

Query: 8248 DNRSVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQAL 8427
            DNRSVTFE+HRE EHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVK+RNLDWFPRMQAL
Sbjct: 2734 DNRSVTFESHREMEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKERNLDWFPRMQAL 2793

Query: 8428 SLQDSELDTDQSEVKQMKDQLLQMMTLMREIISQNEESRAFMEQFQPR 8571
            SLQDSELDTDQSE+KQMKDQ++QMM +MRE  SQ +E RAFMEQ Q R
Sbjct: 2794 SLQDSELDTDQSEMKQMKDQMMQMMAMMRENQSQWDEVRAFMEQLQSR 2841


>gi|7500401|pir||T32552 hypothetical protein F33D4.2c - Caenorhabditis
            elegans
          Length = 1966

 Score = 3794 bits (9839), Expect = 0.0
 Identities = 1907/1966 (96%), Positives = 1912/1966 (96%), Gaps = 6/1966 (0%)
 Frame = +1

Query: 46   MALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKD 225
            MALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKD
Sbjct: 1    MALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKD 60

Query: 226  GRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKERE 405
            GRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKERE
Sbjct: 61   GRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKERE 120

Query: 406  ENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWF 585
            ENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWF
Sbjct: 121  ENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWF 180

Query: 586  IIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLN 765
            IIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLN
Sbjct: 181  IIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLN 240

Query: 766  EPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNR 945
            EPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNR
Sbjct: 241  EPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNR 300

Query: 946  PSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNG 1125
            PSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNG
Sbjct: 301  PSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNG 360

Query: 1126 RPPLLSALSQKSRPMLERTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPE 1305
            RPPLLSALSQKSRPMLERTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPE
Sbjct: 361  RPPLLSALSQKSRPMLERTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPE 420

Query: 1306 EDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWV 1485
            EDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWV
Sbjct: 421  EDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWV 480

Query: 1486 KVICEKNRVDKETFALLPVNPDE------VRDLDFANDACKALRNFIKLIKIGQVISKES 1647
            KVICEKNRVDKETFALLPVNPDE      VRDLDFANDACKALRNFIKLIKIGQVISKES
Sbjct: 481  KVICEKNRVDKETFALLPVNPDEASQSLNVRDLDFANDACKALRNFIKLIKIGQVISKES 540

Query: 1648 INSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLP 1827
            INSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLP
Sbjct: 541  INSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLP 600

Query: 1828 RQGTTXXXXXXXXXXXXXDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQ 2007
            RQGTT             DSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQ
Sbjct: 601  RQGTTELGPLLSSPSELSDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQ 660

Query: 2008 IGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEA 2187
            IGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEA
Sbjct: 661  IGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEA 720

Query: 2188 NKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSNSDDAEHLD 2367
            NKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSNSDDAEHLD
Sbjct: 721  NKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSNSDDAEHLD 780

Query: 2368 YYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTR 2547
            YYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTR
Sbjct: 781  YYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTR 840

Query: 2548 LMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLA 2727
            LMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLA
Sbjct: 841  LMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLA 900

Query: 2728 TVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINE 2907
            TVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINE
Sbjct: 901  TVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINE 960

Query: 2908 GPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKT 3087
            GPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKT
Sbjct: 961  GPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKT 1020

Query: 3088 KLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASELYDAIYRS 3267
            KLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASELYDAIYRS
Sbjct: 1021 KLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASELYDAIYRS 1080

Query: 3268 SGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVS 3447
            SGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVS
Sbjct: 1081 SGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVS 1140

Query: 3448 NNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSP 3627
            NNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSP
Sbjct: 1141 NNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSP 1200

Query: 3628 RAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYP 3807
            RAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYP
Sbjct: 1201 RAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYP 1260

Query: 3808 LIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITL 3987
            LIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITL
Sbjct: 1261 LIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITL 1320

Query: 3988 SHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVP 4167
            SHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVP
Sbjct: 1321 SHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVP 1380

Query: 4168 EELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDN 4347
            EELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDN
Sbjct: 1381 EELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDN 1440

Query: 4348 ASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDH 4527
            ASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDH
Sbjct: 1441 ASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDH 1500

Query: 4528 IVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEK 4707
            IVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEK
Sbjct: 1501 IVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEK 1560

Query: 4708 LTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGK 4887
            LTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGK
Sbjct: 1561 LTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGK 1620

Query: 4888 LRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWI 5067
            LRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWI
Sbjct: 1621 LRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWI 1680

Query: 5068 GIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLV 5247
            GIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLV
Sbjct: 1681 GIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLV 1740

Query: 5248 EVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTK 5427
            EVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTK
Sbjct: 1741 EVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTK 1800

Query: 5428 QQLTHQGHRVYNSSVEKGXXXXXXXXXXYFGHHNNHHPPLDRQQSXXXXXXXXXXXXXXX 5607
            QQLTHQG ++    +++           YFGHHNNHHPPLDRQQS
Sbjct: 1801 QQLTHQGQQLRQLLLQR-----------YFGHHNNHHPPLDRQQSKIGEVIEAVKEKKEE 1849

Query: 5608 TWSQERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFY 5787
            TWSQERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFY
Sbjct: 1850 TWSQERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFY 1909

Query: 5788 MRMKQKDIHEPFFKAILTRIQTAQNRLKSDMMSCSDSKPKVSSTVL 5925
            MRMKQKDIHEPFFKAILTRIQTAQNRLKSDMMSCSDSKPKV    L
Sbjct: 1910 MRMKQKDIHEPFFKAILTRIQTAQNRLKSDMMSCSDSKPKVCKLFL 1955


>gi|14574165|gb|AAK68363.1| Inositol triphosphate receptor protein 1,
            isoform c [Caenorhabditis elegans]
          Length = 1862

 Score = 3623 bits (9395), Expect = 0.0
 Identities = 1815/1854 (97%), Positives = 1817/1854 (97%)
 Frame = +1

Query: 1    MDYDYRRRVLERNIGMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLS 180
            MDYDYRRRVLERNIGMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLS
Sbjct: 1    MDYDYRRRVLERNIGMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLS 60

Query: 181  TLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDD 360
            TLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDD
Sbjct: 61   TLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDD 120

Query: 361  DLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNA 540
            DLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNA
Sbjct: 121  DLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNA 180

Query: 541  MKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSF 720
            MKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSF
Sbjct: 181  MKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSF 240

Query: 721  NLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPK 900
            NLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPK
Sbjct: 241  NLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPK 300

Query: 901  QNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYL 1080
            QNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYL
Sbjct: 301  QNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYL 360

Query: 1081 SAEPSQVQVKPAMNGRPPLLSALSQKSRPMLERTNNPMAMYSDGPNGVTNESTDTTQQNI 1260
            SAEPSQVQVKPAMNGR   L         +  +TNNPMAMYSDGPNGVTNESTDTTQQNI
Sbjct: 361  SAEPSQVQVKPAMNGRRASL---------IYSKTNNPMAMYSDGPNGVTNESTDTTQQNI 411

Query: 1261 PSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATE 1440
            PSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATE
Sbjct: 412  PSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATE 471

Query: 1441 KQNLHYSSKNEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIK 1620
            KQNLHYSSKNEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIK
Sbjct: 472  KQNLHYSSKNEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIK 531

Query: 1621 IGQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVF 1800
            IGQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVF
Sbjct: 532  IGQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVF 591

Query: 1801 LLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLA 1980
            LLLKAPFLPRQGTT             DSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLA
Sbjct: 592  LLLKAPFLPRQGTTELGPLLSSPSELSDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLA 651

Query: 1981 EKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLA 2160
            EKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLA
Sbjct: 652  EKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLA 711

Query: 2161 DLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKS 2340
            DLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKS
Sbjct: 712  DLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKS 771

Query: 2341 NSDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLP 2520
            NSDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLP
Sbjct: 772  NSDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLP 831

Query: 2521 YDLRGSFTRLMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIG 2700
            YDLRGSFTRLMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIG
Sbjct: 832  YDLRGSFTRLMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIG 891

Query: 2701 EGIAHKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLT 2880
            EGIAHKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLT
Sbjct: 892  EGIAHKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLT 951

Query: 2881 QNLLAIINEGPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTK 3060
            QNLLAIINEGPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTK
Sbjct: 952  QNLLAIINEGPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTK 1011

Query: 3061 EGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMAS 3240
            EGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMAS
Sbjct: 1012 EGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMAS 1071

Query: 3241 ELYDAIYRSSGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLED 3420
            ELYDAIYRSSGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLED
Sbjct: 1072 ELYDAIYRSSGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLED 1131

Query: 3421 LKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHD 3600
            LKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHD
Sbjct: 1132 LKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHD 1191

Query: 3601 LLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELS 3780
            LLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELS
Sbjct: 1192 LLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELS 1251

Query: 3781 DKAPLIAYPLIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHD 3960
            DKAPLIAYPLIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHD
Sbjct: 1252 DKAPLIAYPLIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHD 1311

Query: 3961 HDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRN 4140
            HDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRN
Sbjct: 1312 HDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRN 1371

Query: 4141 NRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASD 4320
            NRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASD
Sbjct: 1372 NRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASD 1431

Query: 4321 EVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELK 4500
            EVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELK
Sbjct: 1432 EVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELK 1491

Query: 4501 CASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLE 4680
            CASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLE
Sbjct: 1492 CASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLE 1551

Query: 4681 DIRSLRVEKLTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLL 4860
            DIRSLRVEKLTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLL
Sbjct: 1552 DIRSLRVEKLTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLL 1611

Query: 4861 ELTYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQ 5040
            ELTYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQ
Sbjct: 1612 ELTYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQ 1671

Query: 5041 QAASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPL 5220
            QAASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPL
Sbjct: 1672 QAASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPL 1731

Query: 5221 HAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQT 5400
            HAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQT
Sbjct: 1732 HAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQT 1791

Query: 5401 LCKMCDCTKQQLTHQGHRVYNSSVEKGXXXXXXXXXXYFGHHNNHHPPLDRQQS 5562
            LCKMCDCTKQQLTHQGHRVYNSSVEKG          YFGHHNNHHPPLDRQQS
Sbjct: 1792 LCKMCDCTKQQLTHQGHRVYNSSVEKGQQLRQLLLQRYFGHHNNHHPPLDRQQS 1845


>gi|22532932|gb|AAM98028.1| Inositol triphosphate receptor protein 1,
            isoform g [Caenorhabditis elegans]
          Length = 1713

 Score = 3308 bits (8577), Expect(2) = 0.0
 Identities = 1664/1693 (98%), Positives = 1666/1693 (98%)
 Frame = +1

Query: 1    MDYDYRRRVLERNIGMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLS 180
            MDYDYRRRVLERNIGMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLS
Sbjct: 1    MDYDYRRRVLERNIGMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLS 60

Query: 181  TLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDD 360
            TLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDD
Sbjct: 61   TLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDD 120

Query: 361  DLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNA 540
            DLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNA
Sbjct: 121  DLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNA 180

Query: 541  MKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSF 720
            MKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSF
Sbjct: 181  MKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSF 240

Query: 721  NLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPK 900
            NLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPK
Sbjct: 241  NLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPK 300

Query: 901  QNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYL 1080
            QNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYL
Sbjct: 301  QNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYL 360

Query: 1081 SAEPSQVQVKPAMNGRPPLLSALSQKSRPMLERTNNPMAMYSDGPNGVTNESTDTTQQNI 1260
            SAEPSQVQVKPAMNGR   L         +  +TNNPMAMYSDGPNGVTNESTDTTQQNI
Sbjct: 361  SAEPSQVQVKPAMNGRRASL---------IYSKTNNPMAMYSDGPNGVTNESTDTTQQNI 411

Query: 1261 PSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATE 1440
            PSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATE
Sbjct: 412  PSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATE 471

Query: 1441 KQNLHYSSKNEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIK 1620
            KQNLHYSSKNEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIK
Sbjct: 472  KQNLHYSSKNEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIK 531

Query: 1621 IGQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVF 1800
            IGQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVF
Sbjct: 532  IGQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVF 591

Query: 1801 LLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLA 1980
            LLLKAPFLPRQGTT             DSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLA
Sbjct: 592  LLLKAPFLPRQGTTELGPLLSSPSELSDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLA 651

Query: 1981 EKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLA 2160
            EKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLA
Sbjct: 652  EKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLA 711

Query: 2161 DLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKS 2340
            DLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKS
Sbjct: 712  DLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKS 771

Query: 2341 NSDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLP 2520
            NSDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLP
Sbjct: 772  NSDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLP 831

Query: 2521 YDLRGSFTRLMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIG 2700
            YDLRGSFTRLMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIG
Sbjct: 832  YDLRGSFTRLMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIG 891

Query: 2701 EGIAHKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLT 2880
            EGIAHKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLT
Sbjct: 892  EGIAHKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLT 951

Query: 2881 QNLLAIINEGPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTK 3060
            QNLLAIINEGPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTK
Sbjct: 952  QNLLAIINEGPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTK 1011

Query: 3061 EGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMAS 3240
            EGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMAS
Sbjct: 1012 EGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMAS 1071

Query: 3241 ELYDAIYRSSGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLED 3420
            ELYDAIYRSSGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLED
Sbjct: 1072 ELYDAIYRSSGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLED 1131

Query: 3421 LKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHD 3600
            LKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHD
Sbjct: 1132 LKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHD 1191

Query: 3601 LLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELS 3780
            LLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELS
Sbjct: 1192 LLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELS 1251

Query: 3781 DKAPLIAYPLIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHD 3960
            DKAPLIAYPLIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHD
Sbjct: 1252 DKAPLIAYPLIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHD 1311

Query: 3961 HDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRN 4140
            HDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRN
Sbjct: 1312 HDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRN 1371

Query: 4141 NRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASD 4320
            NRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASD
Sbjct: 1372 NRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASD 1431

Query: 4321 EVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELK 4500
            EVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELK
Sbjct: 1432 EVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELK 1491

Query: 4501 CASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLE 4680
            CASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLE
Sbjct: 1492 CASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLE 1551

Query: 4681 DIRSLRVEKLTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLL 4860
            DIRSLRVEKLTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLL
Sbjct: 1552 DIRSLRVEKLTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLL 1611

Query: 4861 ELTYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQ 5040
            ELTYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQ
Sbjct: 1612 ELTYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQ 1671

Query: 5041 QAASSAKWIGIGK 5079
            QAASSAKWIGIGK
Sbjct: 1672 QAASSAKWIGIGK 1684



 Score = 50.4 bits (119), Expect(2) = 0.0
 Identities = 22/22 (100%), Positives = 22/22 (100%)
 Frame = +3

Query: 5079 ETQSSKYAQSWSSTLWNIKLYD 5144
            ETQSSKYAQSWSSTLWNIKLYD
Sbjct: 1692 ETQSSKYAQSWSSTLWNIKLYD 1713


>gi|46107962|gb|AAB04947.2| inositol 1,4,5-trisphosphate receptor type
            1 [Homo sapiens]
          Length = 2710

 Score = 1654 bits (4282), Expect = 0.0
 Identities = 1074/2926 (36%), Positives = 1574/2926 (53%), Gaps = 109/2926 (3%)
 Frame = +1

Query: 109  LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
            LHIGDI SLY E S+N    GF+STLGLVDDRC+V+ + G   +PPKKFRDCLFK+CP+N
Sbjct: 9    LHIGDICSLYAEGSTN----GFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKLCPMN 64

Query: 289  RYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQ 468
            RY+AQK  W   K     +S  D  L+NKL  AAD E+++NE+E +K LG VIQYG+++Q
Sbjct: 65   RYSAQKQFWKAAK--PGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQ 122

Query: 469  LLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKI 648
            LLH+KSNKY+TV K  PA  E+NAM+V LD AGNEGSWF I+P YK  +IGD+V  G+K+
Sbjct: 123  LLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGDKV 182

Query: 649  SLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSV 828
             L P       AG     LH SS  L+D+    EVN +N  T W++ +F+ + +N+ + +
Sbjct: 183  VLNP-----VNAGQ---PLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDIL 234

Query: 829  KSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTN 1008
            K GDVVRLFHA+Q+ FLT D   K+      VFLR T R SA  ATSS+ALWEV+VVQ +
Sbjct: 235  KGGDVVRLFHAEQEKFLTCDEHRKKQH----VFLRTTGRQSATSATSSKALWEVEVVQHD 290

Query: 1009 AYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRPPLLSALSQKSRPMLERTNN 1188
              RGG   WN  +RFKHLAT  YL+AE      +  +  +P +       SR  L
Sbjct: 291  PCRGGAGYWNSLFRFKHLATGHYLAAEVDPDFEEECLEFQPSV-DPDQDASRSRLRNAQE 349

Query: 1189 PMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPE-EDANLLFQLDPSTFMKSNKE 1365
             M +YS                 + SV          PE  D + +F+LDP+T    +
Sbjct: 350  KM-VYS-----------------LVSV----------PEGNDISSIFELDPTTLRGGDSL 381

Query: 1366 VPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKG-WVKVICEKNRVDKETFALLPV 1542
            VPR SYVRL H  ++ WVH+TN      +    + EK   +K+     + DKE FA++PV
Sbjct: 382  VPRNSYVRLRHLCTNTWVHSTN------IPIDKEEEKPVMLKIGTSPVKEDKEAFAIVPV 435

Query: 1543 NPDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADP 1722
            +P EVRDLDFANDA K L +    ++ G +   E   S T+LL D + FVT  ++   D
Sbjct: 436  SPAEVRDLDFANDASKVLGSIAGKLEKGTITQNER-RSVTKLLEDLVYFVTGGTNSGQDV 494

Query: 1723 LKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIF 1902
            L++    P+R+RQKL+REQ +L Q+F LL+APF     T              D R+  F
Sbjct: 495  LEVVFSKPNRERQKLMREQNILKQIFKLLQAPF-----TDCGDGPMLRLEELGDQRHAPF 549

Query: 1903 KTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKY 2082
            + + +LCY +L++SQ  YRKNQE++A++FG +Q+QIG+D++AEDT+TA+LHNN KLLEK+
Sbjct: 550  RHICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKH 609

Query: 2083 VKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTK 2262
            +    ++ FV LVR NR+ +FLDYL+DLCV   ++    QELIC +VL+  + DI ++TK
Sbjct: 610  ITAAEIDTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETK 669

Query: 2263 II----------------------DGEIEVGWAPNFRKLV-----DIAEGAKSNS-DDAE 2358
            ++                      + E+ + W  + +++      ++A+ AK    +D +
Sbjct: 670  LVLSRFEFEGVSSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDAKEGQKEDRD 729

Query: 2359 HLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGS 2538
             L YYR+QL+L ++MC ++QYLAI+         IS QL  +L+L+CMSD  LPYDLR S
Sbjct: 730  VLSYYRYQLNLFARMCLDRQYLAIN--------EISGQLDVDLILRCMSDENLPYDLRAS 781

Query: 2539 FTRLMLHLHVVRG--SPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIA 2712
            F RLMLH+HV R     ++ +++ARLW  IP  + +  Y+S      S  S+  I E  A
Sbjct: 782  FCRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDS------SGASKDEIKERFA 835

Query: 2713 HKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLL 2892
             + +  VE YL  +  Q          +KLT+E+VNLA+ L  F FY+F+DLL+LT+ LL
Sbjct: 836  -QTMEFVEEYLRDVVCQRFPFSDK-EKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILL 893

Query: 2893 AIINEGPATEQVPSHRAMV-------NAIRN-------MSKSMMRGGNKENSKDLAKTPS 3030
            AI++    T   P  +          N +R+       M++ ++RGG       +A  P
Sbjct: 894  AILDCVHVTTIFPISKMAKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPE 953

Query: 3031 VTAEEAGRTKEGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFP--------- 3183
               ++A   KE   + + TKL + EILQF+++VR DYRI+  L  FK  F
Sbjct: 954  GNVKQAEPEKED-IMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQTSET 1012

Query: 3184 ----CDEDGSLMHSASINERMASELYDAIYRSSGHE--LHLDGRDGQLLLAILLQMTMSD 3345
                  ++G      +++     E  + I+  S     L LD   G+  L +LL +TM D
Sbjct: 1013 SSGNSSQEGPSNVPGALDFEHIEEQAEGIFGGSEENTPLDLDDHGGRTFLRVLLHLTMHD 1072

Query: 3346 YPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSEL 3525
            YPPL S AL++ FRHF+Q QE+L+  KQVQLLV++ DV+NY+QI +DL  L+++ EKSEL
Sbjct: 1073 YPPLVSGALQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSEL 1132

Query: 3526 WVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNE 3705
            WV+  +      + +D      EH   +     P+  +S  S
Sbjct: 1133 WVYKGQGPD---ETMDGASGENEHKKTEEGNNKPQKHESTSSYN---------------- 1173

Query: 3706 CLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDP--KPDTM 3879
                                            Y +++++L+RL+ +C ++     K
Sbjct: 1174 --------------------------------YRVVKEILIRLSKLCVQESASVRKSRKQ 1201

Query: 3880 NQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFIS 4059
             Q+LL+NM  + VVLE + +P++K  D  M +++ L+HEFL++FC  N++NQ+ L+K I+
Sbjct: 1202 QQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHIN 1261

Query: 4060 YEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLELL 4239
               +   G+L   T++       IF NN +L S + E ++ H V  IE + RN  +++ L
Sbjct: 1262 LFLNP--GILEAVTMQH------IFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFL 1313

Query: 4240 QALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSDSR 4419
            Q +V    K I+  Q+ V  E+  + ++V   Y D ASF+ L  MM+ E++      D
Sbjct: 1314 QTIVKAEGKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERDRM----DEN 1369

Query: 4420 RKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLH 4599
              L YHI LV LLA+CT GKN  TE+KC S +P+D IVRVVT + C+ EVK  Y+  L H
Sbjct: 1370 SPLMYHIHLVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNH 1429

Query: 4600 CYIDTDAEMKDAYKTEYVDHILNNLLEDI-RSLRVEKLTGAETATLEHYICHTVTEVLIK 4776
            CY+DT+ EMK+ Y + ++  +  N L DI R+           + LE Y+   V  ++
Sbjct: 1430 CYVDTEVEMKEIYTSNHMWKLFENFLVDICRACNNTXDRKHADSILEKYVTEIVMSIVTT 1489

Query: 4777 FFEAPYSALQQAKVDVHHHKKTFSEVLLEL--TYLEKGKLRGSKSSRNWYRVAECIKRLT 4950
            FF +P+S        +   +  F ++L  +   Y     +   K+S     V  CI+ L+
Sbjct: 1490 FFSSPFS---DQSTTLQTRQPVFVQLLQGVFRVYHCNWLMPSQKAS-----VESCIRVLS 1541

Query: 4951 KWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGHRLYGT 5130
              A+   I +P  L        + V   + ++ S  +   +  RL+ +N       L  +
Sbjct: 1542 DVAKSRAIAIPVDL-------DSQVNNLFLKSHSIVQKTAMNWRLSARNAARRDSVLAAS 1594

Query: 5131 SNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCA 5310
             +        N++     ++   +  L PL  AE SVLV+VLH PELLFPE +  R +C
Sbjct: 1595 RDYR------NIIERLQDIVSALEDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKCE 1648

Query: 5311 RGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKQQLTHQGHRVYNSSVEKGXXX 5490
             GG + KLI+H K L++  ++ LC +VLQTL +M   TK        R Y    EKG
Sbjct: 1649 SGGFICKLIKHTKQLLEENEEKLCIKVLQTLREMM--TKD-------RGYG---EKGEAL 1696

Query: 5491 XXXXXXXYFGHHNNHHPPLDRQQSXXXXXXXXXXX------------XXXXTWSQ-ERDL 5631
                   Y+G+      P  R++S                           + S+ E  L
Sbjct: 1697 RQVLVNRYYGNVR----PSGRRESLTSFGNGPLSAGGPGKPGGGGGGSGSSSMSRGEMSL 1752

Query: 5632 YAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDI 5811
              +QC L+  GAS+LV D+I+   S  +F ++I LA ALL  GN  +QHSF+ R+ +
Sbjct: 1753 AEVQCHLDKEGASNLVIDLIMNASSDRVFHESILLAIALLEGGNTTIQHSFFCRLTEDKK 1812

Query: 5812 HEPFFKAILTRIQTAQNRLKSDM-MSCSDSKPKVSSTVL---TPLIDAGDTGFNGALFEV 5979
             E FFK    R++ AQ  +K+ + ++ SD   K     +    P              EV
Sbjct: 1813 SEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPTTQITEEV 1872

Query: 5980 PQQVRHPSISEMSQLSNDLTHSIPDLAPYQ---------DEEKSTDALPPEVALVEPILR 6132
              Q+   S +     +     + PD   YQ         D+ K    +   + +++PILR
Sbjct: 1873 RDQLLEASAATRKAFTTFRREADPD-DHYQPGEGTQATADKAKDDLEMSAVITIMQPILR 1931

Query: 6133 VLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFG-EIGEHNFS 6309
             LQLLCENHN  LQNFLR Q+++TN+NLV ETL FLD +CGST G LG+ G  I E N +
Sbjct: 1932 FLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINEKNVA 1991

Query: 6310 LITQTLATLTEFCQGPCHENQNTMAMQE-NGLNIIISLVLNEIKPLADDHMELALEIKSQ 6486
            LI QTL +LTE+CQGPCHENQN +A  E NG++II +L+LN              +I
Sbjct: 1992 LINQTLESLTEYCQGPCHENQNCIATHESNGIDIITALILN--------------DINPL 2037

Query: 6487 ASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDL 6666
              K +  ++E           L+N A+     K L+  ++  ++  N+   +     ++L
Sbjct: 2038 GKKRMDLVLE-----------LKNNAS-----KLLLAIMESRHDSENAERILYNMRPKEL 2081

Query: 6667 FRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDP 6846
                  ++ KK+  Q  V                            +D  N +D  +  P
Sbjct: 2082 V-----EVIKKAYMQGEVE--------------------------FEDGENGED-GAASP 2109

Query: 6847 REVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTLE 7026
            R VGHNIYILAHQLA H+ EL+  L    +   D   EAL +Y + TAQIEIVR DRT+E
Sbjct: 2110 RNVGHNIYILAHQLARHNKELQSMLKPGGQVDGD---EALEFYAKHTAQIEIVRLDRTME 2166

Query: 7027 RVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWL 7206
            ++VFP+  IC +LTK++K  +Y  TERD QGSK+ +FF   E +++EM WQ+KL+ +  L
Sbjct: 2167 QIVFPVPSICEFLTKESKLRIYYTTERDEQGSKINDFFLRSEDLFNEMNWQKKLRAQPVL 2226

Query: 7207 SWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSIS---LGNLYSWFAVFSSFLLA 7377
             WCA  +  W+ +SF+ A ++N LVA  YPL      ++     G L++   +  + ++A
Sbjct: 2227 YWCARNMSFWSSISFNLAVLMNLLVAFLYPLKGVRGGTLEPHWSGLLWTAMLISLAIVIA 2286

Query: 7378 HYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLE 7557
                H                       +G+  TL++ G   + NKI+ +++FV N G
Sbjct: 2287 LPKPHG-------IRALIASTILRLIFSVGLQPTLFLLGAFNVCNKIIFLMSFVGNCGTF 2339

Query: 7558 DRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQ 7737
             R    ++      Y L+YL IC +GL VH   Y +LLFD+++ EETL NVI SVTRN +
Sbjct: 2340 TRGYRAMVLDVEFLYHLLYLVICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGR 2399

Query: 7738 SIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSS------ATISSGIPSETC-- 7893
            SI+ T +LALIL+Y FSI+G+L+F+ DF LEVD + N+++      +  S  + S+ C
Sbjct: 2400 SIILTAVLALILVYLFSIVGYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDVCRV 2459

Query: 7894 -PSEGCPGLQPSXX---XXXXXXXXXXSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPW 8061
               E C    P                +CETL MCI+     GLR+GGG+GDVLR P+
Sbjct: 2460 ESGENCSSPAPREELVPAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKE 2519

Query: 8062 EDMFIWRVAYDMTXXXXXXXXXXXXXXXXXXDTFGDLRAEKNEKEQILKNNCFICGLDRS 8241
            E +F  RV YD+                   DTF DLR+EK +KE+ILK  CFICGL+R
Sbjct: 2520 EPLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERX 2579

Query: 8242 RFDNRSVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQ 8421
            +FDN++VTFE H + EHN+WHYL +IV++++KD TE+TGPESYVA+ +K+RNLDWFPRM+
Sbjct: 2580 KFDNKTVTFEEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFPRMR 2639

Query: 8422 ALSLQDSELDTDQSEVKQMKDQLLQMMTLMREIISQNEESRAFMEQ 8559
            A+SL  S+ + +Q+E++ ++++L   M L+  +  Q  E +  M +
Sbjct: 2640 AMSLVSSDSEGEQNELRNLQEKLESTMKLVTNLSGQLSELKDQMTE 2685


>gi|10835023|ref|NP_002213.1| inositol 1,4,5-triphosphate receptor,
            type 1 [Homo sapiens]
 gi|1085408|pir||S54974 type 1 inositol 1,4,5-trisphosphate receptor -
            human
 gi|559323|dbj|BAA05065.1| human type 1 inositol 1,4,5-trisphosphate
            receptor [Homo sapiens]
          Length = 2695

 Score = 1651 bits (4276), Expect = 0.0
 Identities = 1073/2926 (36%), Positives = 1570/2926 (52%), Gaps = 109/2926 (3%)
 Frame = +1

Query: 109  LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
            LHIGDI SLY E S+N    GF+STLGLVDDRC+V+ + G   +PPKKFRDCLFK+CP+N
Sbjct: 9    LHIGDICSLYAEGSTN----GFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKLCPMN 64

Query: 289  RYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQ 468
            RY+AQK  W   K     +S  D  L+NKL  AAD E+++NE+E +K LG VIQYG+++Q
Sbjct: 65   RYSAQKQFWKAAK--PGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQ 122

Query: 469  LLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKI 648
            LLH+KSNKY+TV K  PA  E+NAM+V LD AGNEGSWF I+P YK  +IGD+V  G+K+
Sbjct: 123  LLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGDKV 182

Query: 649  SLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSV 828
             L P       AG     LH SS  L+D+    EVN +N  T W++ +F+ + +N+ + +
Sbjct: 183  VLNP-----VNAGQ---PLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDIL 234

Query: 829  KSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTN 1008
            K GDVVRLFHA+Q+ FLT D   K+      VFLR T R SA  ATSS+ALWEV+VVQ +
Sbjct: 235  KGGDVVRLFHAEQEKFLTCDEHRKKQH----VFLRTTGRQSATSATSSKALWEVEVVQHD 290

Query: 1009 AYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRPPLLSALSQKSRPMLERTNN 1188
              RGG   WN  +RFKHLAT  YL+AE    Q                  SR  L
Sbjct: 291  PCRGGAGYWNSLFRFKHLATGHYLAAEVDPDQ----------------DASRSRLRNAQE 334

Query: 1189 PMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPE-EDANLLFQLDPSTFMKSNKE 1365
             M +YS                 + SV          PE  D + +F+LDP+T    +
Sbjct: 335  KM-VYS-----------------LVSV----------PEGNDISSIFELDPTTLRGGDSL 366

Query: 1366 VPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKG-WVKVICEKNRVDKETFALLPV 1542
            VPR SYVRL H  ++ WVH+TN      +    + EK   +K+     + DKE FA++PV
Sbjct: 367  VPRNSYVRLRHLCTNTWVHSTN------IPIDKEEEKPVMLKIGTSPVKEDKEAFAIVPV 420

Query: 1543 NPDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADP 1722
            +P EVRDLDFANDA K L +    ++ G +   E   S T+LL D + FVT  ++   D
Sbjct: 421  SPAEVRDLDFANDASKVLGSIAGKLEKGTITQNER-RSVTKLLEDLVYFVTGGTNSGQDV 479

Query: 1723 LKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIF 1902
            L++    P+R+RQKL+REQ +L Q+F LL+APF     T              D R+  F
Sbjct: 480  LEVVFSKPNRERQKLMREQNILKQIFKLLQAPF-----TDCGDGPMLRLEELGDQRHAPF 534

Query: 1903 KTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKY 2082
            + + +LCY +L++SQ  YRKNQE++A++FG +Q+QIG+D++AEDT+TA+LHNN KLLEK+
Sbjct: 535  RHICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKH 594

Query: 2083 VKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTK 2262
            +    ++ FV LVR NR+ +FLDYL+DLCV   ++    QELIC +VL+  + DI ++TK
Sbjct: 595  ITAAEIDTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETK 654

Query: 2263 II----------------------DGEIEVGWAPNFRKLV-----DIAEGAKSNS-DDAE 2358
            ++                      + E+ + W  + +++      ++A+ AK    +D +
Sbjct: 655  LVLSRFEFEGVSSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDAKEGQKEDRD 714

Query: 2359 HLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGS 2538
             L YYR+QL+L ++MC ++QYLAI+         IS QL  +L+L+CMSD  LPYDLR S
Sbjct: 715  VLSYYRYQLNLFARMCLDRQYLAIN--------EISGQLDVDLILRCMSDENLPYDLRAS 766

Query: 2539 FTRLMLHLHVVRG--SPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIA 2712
            F RLMLH+HV R     ++ +++ARLW  IP  + +  Y+S      S  S+  I E  A
Sbjct: 767  FCRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDS------SGASKDEIKERFA 820

Query: 2713 HKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLL 2892
             + +  VE YL  +  Q          +KLT+E+VNLA+ L  F FY+F+DLL+LT+ LL
Sbjct: 821  -QTMEFVEEYLRDVVCQRFPFSDK-EKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILL 878

Query: 2893 AIINEGPATEQVPSHRAMV-------NAIRN-------MSKSMMRGGNKENSKDLAKTPS 3030
            AI++    T   P  +          N +R+       M++ ++RGG       +A  P
Sbjct: 879  AILDCVHVTTIFPISKMAKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPE 938

Query: 3031 VTAEEAGRTKEGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFP--------- 3183
               ++A   KE   + + TKL + EILQF+++VR DYRI+  L  FK  F
Sbjct: 939  GNVKQAEPEKED-IMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQTSET 997

Query: 3184 ----CDEDGSLMHSASINERMASELYDAIYRSSGHE--LHLDGRDGQLLLAILLQMTMSD 3345
                  ++G      +++     E  + I+  S     L LD   G+  L +LL +TM D
Sbjct: 998  SSGNSSQEGPSNVPGALDFEHIEEQAEGIFGGSEENTPLDLDDHGGRTFLRVLLHLTMHD 1057

Query: 3346 YPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSEL 3525
            YPPL S AL++ FRHF+Q QE+L+  KQVQLLV++ DV+NY+QI +DL  L+++ EKSEL
Sbjct: 1058 YPPLVSGALQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSEL 1117

Query: 3526 WVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNE 3705
            WV+  +      + +D      EH   +     P+  +S  S
Sbjct: 1118 WVYKGQGPD---ETMDGASGENEHKKTEEGNNKPQKHESTSSYN---------------- 1158

Query: 3706 CLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDP--KPDTM 3879
                                            Y +++++L+RL+ +C ++     K
Sbjct: 1159 --------------------------------YRVVKEILIRLSKLCVQESASVRKSRKQ 1186

Query: 3880 NQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFIS 4059
             Q+LL+NM  + VVLE + +P++K  D  M +++ L+HEFL++FC  N++NQ+ L+K I+
Sbjct: 1187 QQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHIN 1246

Query: 4060 YEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLELL 4239
               +   G+L   T++       IF NN +L S + E ++ H V  IE + RN  +++ L
Sbjct: 1247 LFLNP--GILEAVTMQH------IFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFL 1298

Query: 4240 QALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSDSR 4419
            Q +V    K I+  Q+ V  E+  + ++V   Y D ASF+ L  MM+ E++      D
Sbjct: 1299 QTIVKAEGKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERDRM----DEN 1354

Query: 4420 RKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLH 4599
              L YHI LV LLA+CT GKN  TE+KC S +P+D IVRVVT + C+ EVK  Y+  L H
Sbjct: 1355 SPLMYHIHLVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNH 1414

Query: 4600 CYIDTDAEMKDAYKTEYVDHILNNLLEDI-RSLRVEKLTGAETATLEHYICHTVTEVLIK 4776
            CY+DT+ EMK+ Y + ++  +  N L DI R+           + LE Y+   V  ++
Sbjct: 1415 CYVDTEVEMKEIYTSNHMWKLFENFLVDICRACNNTSDRKHADSILEKYVTEIVMSIVTT 1474

Query: 4777 FFEAPYSALQQAKVDVHHHKKTFSEVLLEL--TYLEKGKLRGSKSSRNWYRVAECIKRLT 4950
            FF +P+S        +   +  F ++L  +   Y     +   K+S     V  CI+ L+
Sbjct: 1475 FFSSPFS---DQSTTLQTRQPVFVQLLQGVFRVYHCNWLMPSQKAS-----VESCIRVLS 1526

Query: 4951 KWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGHRLYGT 5130
              A+   I +P  L        + V   + ++ S  +   +  RL+ +N       L  +
Sbjct: 1527 DVAKSRAIAIPVDL-------DSQVNNLFLKSHSIVQKTAMNWRLSARNAARRDSVLAAS 1579

Query: 5131 SNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCA 5310
             +        N++     ++   +  L PL  AE SVLV+VLH PELLFPE +  R +C
Sbjct: 1580 RDYR------NIIERLQDIVSALEDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKCE 1633

Query: 5311 RGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKQQLTHQGHRVYNSSVEKGXXX 5490
             GG + KLI+H K L++  ++ LC +VLQTL +M   TK        R Y    EKG
Sbjct: 1634 SGGFICKLIKHTKQLLEENEEKLCIKVLQTLREMM--TKD-------RGYG---EKGEAL 1681

Query: 5491 XXXXXXXYFGHHNNHHPPLDRQQSXXXXXXXXXXX------------XXXXTWSQ-ERDL 5631
                   Y+G+      P  R++S                           + S+ E  L
Sbjct: 1682 RQVLVNRYYGNVR----PSGRRESLTSFGNGPLSAGGPGKPGGGGGGSGSSSMSRGEMSL 1737

Query: 5632 YAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDI 5811
              +QC L+  GAS+LV D+I+   S  +F ++I LA ALL  GN  +QHSF+ R+ +
Sbjct: 1738 AEVQCHLDKEGASNLVIDLIMNASSDRVFHESILLAIALLEGGNTTIQHSFFCRLTEDKK 1797

Query: 5812 HEPFFKAILTRIQTAQNRLKSDM-MSCSDSKPKVSSTVL---TPLIDAGDTGFNGALFEV 5979
             E FFK    R++ AQ  +K+ + ++ SD   K     +    P              EV
Sbjct: 1798 SEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPTTQITEEV 1857

Query: 5980 PQQVRHPSISEMSQLSNDLTHSIPDLAPYQ---------DEEKSTDALPPEVALVEPILR 6132
              Q+   S +     +     + PD   YQ         D+ K    +   + +++PILR
Sbjct: 1858 RDQLLEASAATRKAFTTFRREADPD-DHYQPGEGTQATADKAKDDLEMSAVITIMQPILR 1916

Query: 6133 VLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFG-EIGEHNFS 6309
             LQLLCENHN  LQNFLR Q+++TN+NLV ETL FLD +CGST G LG+ G  I E N +
Sbjct: 1917 FLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINEKNVA 1976

Query: 6310 LITQTLATLTEFCQGPCHENQNTMAMQE-NGLNIIISLVLNEIKPLADDHMELALEIKSQ 6486
            LI QTL +LTE+CQGPCHENQN +A  E NG++II +L+LN              +I
Sbjct: 1977 LINQTLESLTEYCQGPCHENQNCIATHESNGIDIITALILN--------------DINPL 2022

Query: 6487 ASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDL 6666
              K +  ++E           L+N A+     K L+  ++  ++  N+   +     ++L
Sbjct: 2023 GKKRMDLVLE-----------LKNNAS-----KLLLAIMESRHDSENAERILYNMRPKEL 2066

Query: 6667 FRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDP 6846
                  ++ KK+  Q  V                            +D  N +D  +  P
Sbjct: 2067 V-----EVIKKAYMQGEVE--------------------------FEDGENGED-GAASP 2094

Query: 6847 REVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTLE 7026
            R VGHNIYILAHQLA H+ EL+  L    +   D   EAL +Y + TAQIEIVR DRT+E
Sbjct: 2095 RNVGHNIYILAHQLARHNKELQSMLKPGGQVDGD---EALEFYAKHTAQIEIVRLDRTME 2151

Query: 7027 RVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWL 7206
            ++VFP+  IC +LTK++K  +Y  TERD QGSK+ +FF   E +++EM WQ+KL+ +  L
Sbjct: 2152 QIVFPVPSICEFLTKESKLRIYYTTERDEQGSKINDFFLRSEDLFNEMNWQKKLRAQPVL 2211

Query: 7207 SWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSIS---LGNLYSWFAVFSSFLLA 7377
             WCA  +  W+ +SF+ A ++N LVA +YP       ++     G L++   +  + ++A
Sbjct: 2212 YWCARNMSFWSSISFNLAVLMNLLVAFFYPFKGVRGGTLEPHWSGLLWTAMLISLAIVIA 2271

Query: 7378 HYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLE 7557
                H                       +G+  TL++ G   + NKI+ +++FV N G
Sbjct: 2272 LPKPHG-------IRALIASTILRLIFSVGLQPTLFLLGAFNVCNKIIFLMSFVGNCGTF 2324

Query: 7558 DRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQ 7737
             R    ++      Y L+YL IC +GL VH   Y +LLFD+++ EETL NVI SVTRN +
Sbjct: 2325 TRGYRAMVLDVEFLYHLLYLVICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGR 2384

Query: 7738 SIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSS------ATISSGIPSETC-- 7893
            SI+ T +LALIL+Y FSI+G+L+F+ DF LEVD + N+++      +  S  + S+ C
Sbjct: 2385 SIILTAVLALILVYLFSIVGYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDVCRV 2444

Query: 7894 -PSEGCPGLQPSXX---XXXXXXXXXXSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPW 8061
               E C    P                +CETL MCI+     GLR+GGG+GDVLR P+
Sbjct: 2445 ESGENCSSPAPREELVPAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKE 2504

Query: 8062 EDMFIWRVAYDMTXXXXXXXXXXXXXXXXXXDTFGDLRAEKNEKEQILKNNCFICGLDRS 8241
            E +F  RV YD+                   DTF DLR+EK +KE+ILK  CFICGL+R
Sbjct: 2505 EPLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERD 2564

Query: 8242 RFDNRSVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQ 8421
            +FDN++VTFE H + EHN+WHYL +IV++++KD TE+TGPESYVA+ +K+RNLDWFPRM+
Sbjct: 2565 KFDNKTVTFEEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFPRMR 2624

Query: 8422 ALSLQDSELDTDQSEVKQMKDQLLQMMTLMREIISQNEESRAFMEQ 8559
            A+SL  S+ + +Q+E++ ++++L   M L+  +  Q  E +  M +
Sbjct: 2625 AMSLVSSDSEGEQNELRNLQEKLESTMKLVTNLSGQLSELKDQMTE 2670


>gi|34857738|ref|XP_342733.1| similar to Inositol 1,4,5-trisphosphate
            receptor type 1 (Type 1 inositol 1,4,5-trisphosphate
            receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform
            1) (InsP3R1) (IP-3-R) [Rattus norvegicus]
          Length = 2749

 Score = 1644 bits (4257), Expect = 0.0
 Identities = 1067/2953 (36%), Positives = 1573/2953 (53%), Gaps = 136/2953 (4%)
 Frame = +1

Query: 109  LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
            LHIGDI SLY E S+N    GF+STLGLVDDRC+V+ + G   +PPKKFRDCLFK+CP+N
Sbjct: 9    LHIGDICSLYAEGSTN----GFISTLGLVDDRCVVQPEAGDLNNPPKKFRDCLFKLCPMN 64

Query: 289  RYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQ 468
            RY+AQK  W   K     +S  D  L+NKL  AAD E+++NE+E +K LG VIQYG+++Q
Sbjct: 65   RYSAQKQFWKAAK--PGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQ 122

Query: 469  LLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKI 648
            LLH+KSNKY+TV K  PA  E+NAM+V LD AGNEGSWF I+P YK  +IGD+V  G+K+
Sbjct: 123  LLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGDKV 182

Query: 649  SLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSV 828
             L P       AG     LH SS  L+D+    EVN +N  T W++ +F+ + +N+ + +
Sbjct: 183  VLNP-----VNAGQ---PLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDIL 234

Query: 829  KSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTN 1008
            K GDVVRLFHA+Q+ FLT D   K+      VFLR T R SA  ATSS+ALWEV+VVQ +
Sbjct: 235  KGGDVVRLFHAEQEKFLTCDEHRKKQH----VFLRTTGRQSATSATSSKALWEVEVVQHD 290

Query: 1009 AYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRPPLLSALSQKSRPMLERTNN 1188
              RGG   WN  +RFKHLAT  YL+AE      +  +  +P +       SR  L
Sbjct: 291  PCRGGAGYWNSLFRFKHLATGHYLAAEVDPDFEEECLEFQPSV-DPDQDASRSRLRNAQE 349

Query: 1189 PMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPE-EDANLLFQLDPSTFMKSNKE 1365
             M +YS                 + SV          PE  D + +F+LDP+T    +
Sbjct: 350  KM-VYS-----------------LVSV----------PEGNDISSIFELDPTTLRGGDSL 381

Query: 1366 VPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKG-WVKVICEKNRVDKETFALLPV 1542
            VPR SYVRL H  ++ WVH+TN      +    + EK   +K+     + DKE FA++PV
Sbjct: 382  VPRNSYVRLRHLCTNTWVHSTN------IPIDKEEEKPVMLKIGTSPLKEDKEAFAIVPV 435

Query: 1543 NPDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADP 1722
            +P EVRDLDFANDA K L +    ++ G +   E   S T+LL D + FVT  ++   D
Sbjct: 436  SPAEVRDLDFANDASKVLGSIAGKLEKGTITQNER-RSVTKLLEDLVYFVTGGTNSGQDV 494

Query: 1723 LKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIF 1902
            L++    P+R+RQKL+REQ +L Q+F LL+APF     T              D R+  F
Sbjct: 495  LEVVFSKPNRERQKLMREQNILKQIFKLLQAPF-----TDCGDGPMLRLEELGDQRHAPF 549

Query: 1903 KTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKY 2082
            + + +LCY +L++SQ  YRKNQE++A++FG +Q+QIG+D++AEDT+TA+LHNN KLLEK+
Sbjct: 550  RHICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKH 609

Query: 2083 VKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTK 2262
            +    ++ FV LVR NR+ +FLDYL+DLCV   ++    QELIC +VL+  + DI ++TK
Sbjct: 610  ITAAEIDTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETK 669

Query: 2263 II---------------------DGEIEVGWAPNFRKLV-----DIAEGAKSNS-DDAEH 2361
            ++                     + E+ + W  + +++      ++A+ AK    +D +
Sbjct: 670  LVLSRFEFEGVSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDAKEGQKEDRDV 729

Query: 2362 LDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSF 2541
            L YYR+QL+L ++MC ++QYLAI+         IS QL  +L+L+CMSD  LPYDLR SF
Sbjct: 730  LSYYRYQLNLFARMCLDRQYLAIN--------EISGQLDVDLILRCMSDENLPYDLRASF 781

Query: 2542 TRLMLHLHVVRG--SPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAH 2715
             RLMLH+HV R     ++ +++ARLW  IP  + +  Y+S      S  S+  I E  A
Sbjct: 782  CRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDS------SGASKDEIKERFA- 834

Query: 2716 KVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLA 2895
            + +  VE YL  +  Q          +KLT+E+VNLA+ L  F FY+F+DLL+LT+ LLA
Sbjct: 835  QTMEFVEEYLRDVVCQRFPFSDK-EKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLA 893

Query: 2896 IINEGPATEQVPSHRAMV-------NAIRN-------MSKSMMRGGNKENSKDLAKTPSV 3033
            I++    T   P  +          N +R+       M++ ++RGG       +A  P
Sbjct: 894  ILDCVHVTTIFPISKMTKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEG 953

Query: 3034 TAEEAGRTKEGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFP---------- 3183
              ++A   KE   + + TKL + EILQF+++VR DYRI+  L  FK  F
Sbjct: 954  NVKQAEPEKED-IMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQSSETS 1012

Query: 3184 ---CDEDGSLMHSASINERMASELYDAIYRSSGHE--LHLDGRDGQLLLAILLQMTMSDY 3348
                 ++G      +++     E  + I+  S     L LD   G+  L +LL +TM DY
Sbjct: 1013 SGNSSQEGPSNVPGALDFEHIEEQAEGIFGGSEENTPLDLDDHGGRTFLRVLLHLTMHDY 1072

Query: 3349 PPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELW 3528
            PPL S AL++ FRHF+Q QE+L+  KQVQLLV++ DV+NY+QI +DL  L+++ EKSELW
Sbjct: 1073 PPLVSGALQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELW 1132

Query: 3529 VHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNEC 3708
            V+  +      + +D      EH   +     P   +S  S
Sbjct: 1133 VYKGQGPD---EPMDGASGENEHKKTEEGTSKPLKHESTSSYN----------------- 1172

Query: 3709 LQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDP--KPDTMN 3882
                                           Y +++++L+RL+ +C ++     K
Sbjct: 1173 -------------------------------YRVVKEILIRLSKLCVQESASVRKSRKQQ 1201

Query: 3883 QQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFISY 4062
            Q+LL+NM  + VVLE + +P++K  D  M +++ L+HEFL++FC  N++NQ+ L+K I+
Sbjct: 1202 QRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHINL 1261

Query: 4063 EKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQ 4242
              +   G+L   T++       IF NN +L S + E ++ H V  IE + RN  +++ LQ
Sbjct: 1262 FLNP--GILEAVTMQH------IFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQ 1313

Query: 4243 ALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSDSRR 4422
             +V    K I+  Q+ V  E+  + ++V   Y D ASF+ L  MM+ E++      D
Sbjct: 1314 TIVKAEGKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERDRM----DENS 1369

Query: 4423 KLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHC 4602
             L YHI LV LLA+CT GKN  TE+KC S +P+D IVRVVT + C+ EVK  Y+  L HC
Sbjct: 1370 PLMYHIHLVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHC 1429

Query: 4603 YIDTDAEMKDAYKTEYVDHILNNLLEDI-RSLRVEKLTGAETATLEHYICHTVTEVLIKF 4779
            Y+DT+ EMK+ Y + ++  +  N L DI R+           + LE Y+   V  ++  F
Sbjct: 1430 YVDTEVEMKEIYTSNHMWKLFENFLVDICRACNNTSDRKHADSVLEKYVTEIVMSIVTTF 1489

Query: 4780 FEAPYSALQQAKVDVHHHKKTFSEVLLEL--TYLEKGKLRGSKSSRNWYRVAECIKRLTK 4953
            F +P+S        +   +  F ++L  +   Y     +   K+S     V  CI+ L+
Sbjct: 1490 FSSPFS---DQSTTLQTRQPVFVQLLQGVFRVYHCNWLMPSQKAS-----VESCIRVLSD 1541

Query: 4954 WAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGHRLYGTS 5133
             A+   I +P  L        + V   + ++ +  +   +  RL+ +N       L  +
Sbjct: 1542 VAKSRAIAIPVDL-------DSQVNNLFLKSHNIVQKTAMNWRLSARNAARRDSVLAASR 1594

Query: 5134 NSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCAR 5313
            +        N++     ++   +  L PL  AE SVLV+VLH PELLFPE +  R +C
Sbjct: 1595 DYR------NIIERLQDIVSALEDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKCES 1648

Query: 5314 GGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMC-------------------------- 5415
            GG + KLI+H K L++  ++ LC +VLQTL +M
Sbjct: 1649 GGFICKLIKHTKQLLEENEEKLCIKVLQTLREMMTKDRGYGEKQISIDELENAELPQPPE 1708

Query: 5416 --DCTKQQLTHQGHRVYNSSVEKGXXXXXXXXXXYFGHHNNHHPPLDRQQSXXXXXXXXX 5589
              + T+Q+L            ++G          Y+G+      P  R++S
Sbjct: 1709 AENSTEQELEPSPPLRQLEDHKRGEALRQILVNRYYGNIR----PSGRRESLTSFGNGPL 1764

Query: 5590 XXX-------------XXXTWSQERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAI 5730
                               T   E  L  +QC L+  GAS+LV D+I+   S  +F ++I
Sbjct: 1765 SPGGPSKPGGGGGGPGSGSTSRGEMSLAEVQCHLDKEGASNLVIDLIMNASSDRVFHESI 1824

Query: 5731 HLARALLHEGNDKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRLKSDM-MSCSDSKPK 5907
             LA ALL  GN  +QHSF+ R+ +    E FFK    R++ AQ  +K+ + ++ SD   K
Sbjct: 1825 LLAIALLEGGNTTIQHSFFCRLTEDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNK 1884

Query: 5908 VSSTVL---TPLIDAGDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQ--- 6069
                 +    P              EV  Q+   S +     +     + PD   YQ
Sbjct: 1885 KKDDEVDRDAPSRKKAKEPTTQITEEVRDQLLEASAATRKAFTTFRREADPD-DHYQSGE 1943

Query: 6070 ------DEEKSTDALPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETL 6231
                  D+ K    +   + +++PILR LQLLCENHN  LQNFLR Q+++TN+NLV ETL
Sbjct: 1944 GTQATTDKAKDDLEMSAVITIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETL 2003

Query: 6232 SFLDTVCGSTKGSLGVFG-EIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQE-NGLN 6405
             FLD +CGST G LG+ G  I E N +LI QTL +LTE+CQGPCHENQN +A  E NG++
Sbjct: 2004 QFLDCICGSTTGGLGLLGLYINEKNVALINQTLESLTEYCQGPCHENQNCIATHESNGID 2063

Query: 6406 IIISLVLNEIKPLADDHMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPK 6585
            II +L+LN              +I     K +  ++E           L+N A+     K
Sbjct: 2064 IITALILN--------------DINPLGKKRMDLVLE-----------LKNNAS-----K 2093

Query: 6586 QLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGI 6765
             L+  ++  ++  N+   +     ++L      ++ KK+  Q  V
Sbjct: 2094 LLLAIMESRHDSENAERILYNMRPKELV-----EVIKKAYMQGEVE-------------- 2134

Query: 6766 VSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKKD 6945
                         +D  N +D  +  PR VGHNIYILAHQLA H+ EL+  L    +
Sbjct: 2135 ------------FEDGENGED-GAASPRNVGHNIYILAHQLARHNKELQTMLKPGGQVDG 2181

Query: 6946 DLTREALNYYKERTAQIEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSK 7125
            D   EAL +Y + TAQIEIVR DRT+E++VFP+  IC +LTK++K  +Y  TERD QGSK
Sbjct: 2182 D---EALEFYAKHTAQIEIVRLDRTMEQIVFPVPSICEFLTKESKLRIYYTTERDEQGSK 2238

Query: 7126 VTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPE 7305
            + +FF   E +++EM WQ+KL+ +  L WCA  +  W+ +SF+ A ++N LVA +YP
Sbjct: 2239 INDFFLRSEDLFNEMNWQKKLRAQPVLYWCARNMSFWSSISFNLAVLMNLLVAFFYPFKG 2298

Query: 7306 HSNSSIS---LGNLYSWFAVFSSFLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTL 7476
                ++     G L++   +  + ++A    H                       +G+
Sbjct: 2299 VRGGTLEPHWSGLLWTAMLISLAIVIALPKPHG-------IRALIASTILRLIFSVGLQP 2351

Query: 7477 TLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMI 7656
            TL++ G   + NKI+ +++FV N G   R    ++      Y L+YL IC +GL VH
Sbjct: 2352 TLFLLGAFNVCNKIIFLMSFVGNCGTFTRGYRAMVLDVEFLYHLLYLLICAMGLFVHEFF 2411

Query: 7657 YCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVD 7836
            Y +LLFD+++ EETL NVI SVTRN +SI+ T +LALIL+Y FSI+G+L+F+ DF LEVD
Sbjct: 2412 YSLLLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSIVGYLFFKDDFILEVD 2471

Query: 7837 PVENDSS------ATISSGIPSETC---PSEGCPGLQPSXXXX---XXXXXXXXSCETLW 7980
             + N+++      +  +  + S+ C     E C    P                +CETL
Sbjct: 2472 RLPNETAGPETGESLANDFLYSDVCRVETGENCTSPAPKEELLPVEETEQDKEHTCETLL 2531

Query: 7981 MCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTXXXXXXXXXXXXXXXXXXDT 8160
            MCI+     GLR+GGG+GDVLR P+  E +F  RV YD+                   DT
Sbjct: 2532 MCIVTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVIYDLLFFFMVIIIVLNLIFGVIIDT 2591

Query: 8161 FGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLYYIVMLQIKD 8340
            F DLR+EK +KE+ILK  CFICGL+R +FDN++VTFE H + EHN+WHYL +IV++++KD
Sbjct: 2592 FADLRSEKQKKEEILKTTCFICGLERDKFDNKTVTFEEHIKEEHNMWHYLCFIVLVKVKD 2651

Query: 8341 ETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLLQMMTLMREI 8520
             TE+TGPESYVA+ +++RNLDWFPRM+A+SL  S+ + +Q+E++ ++++L   M L+  +
Sbjct: 2652 STEYTGPESYVAEMIRERNLDWFPRMRAMSLVSSDSEGEQNELRNLQEKLESTMKLVTNL 2711

Query: 8521 ISQNEESRAFMEQ 8559
              Q  E +  M +
Sbjct: 2712 SGQLSELKDQMTE 2724


>gi|6754390|ref|NP_034715.1| inositol 1,4,5-triphosphate receptor 1;
            InsP3R type I; Purkinje cell protein 1; opisthotonus;
            InsP>3gi|17380349|sp|P29994|IP3R_RAT Inositol 1,4,5-trisphosphate receptor
            type 1 (Type 1 inositol 1,4,5-trisphosphate receptor)
            (Type 1 InsP3 receptor) (IP3 receptor isoform 1)
            (InsP3R1) (IP-3-R)
          Length = 2750

 Score = 1640 bits (4247), Expect = 0.0
 Identities = 1065/2953 (36%), Positives = 1572/2953 (53%), Gaps = 136/2953 (4%)
 Frame = +1

Query: 109  LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
            LHIGDI SLY E S+N    GF+STLGLVDDRC+V+ + G   +PPKKFRDCLFK+CP+N
Sbjct: 9    LHIGDICSLYAEGSTN----GFISTLGLVDDRCVVQPEAGDLNNPPKKFRDCLFKLCPMN 64

Query: 289  RYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQ 468
            RY+AQK  W   K     +S  D  L+NKL  AAD E+++NE+E +K LG VIQYG+++Q
Sbjct: 65   RYSAQKQFWKAAK--PGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQ 122

Query: 469  LLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKI 648
            LLH+KSNKY+TV K  PA  E+NAM+V LD AGNEGSWF I+P YK  +IGD+V  G+K+
Sbjct: 123  LLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGDKV 182

Query: 649  SLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSV 828
             L P       AG     LH SS  L+D+    EVN +N  T W++ +F+ + +N+ + +
Sbjct: 183  VLNP-----VNAGQ---PLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDIL 234

Query: 829  KSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTN 1008
            K GDVVRLFHA+Q+ FLT D   K+      VFLR T R SA  ATSS+ALWEV+VVQ +
Sbjct: 235  KGGDVVRLFHAEQEKFLTCDEHRKKQH----VFLRTTGRQSATSATSSKALWEVEVVQHD 290

Query: 1009 AYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRPPLLSALSQKSRPMLERTNN 1188
              RGG   WN  +RFKHLAT  YL+AE      +  +  +P +       SR  L
Sbjct: 291  PCRGGAGYWNSLFRFKHLATGHYLAAEVDPDFEEECLEFQPSV-DPDQDASRSRLRNAQE 349

Query: 1189 PMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPE-EDANLLFQLDPSTFMKSNKE 1365
             M +YS                 + SV          PE  D + +F+LDP+T    +
Sbjct: 350  KM-VYS-----------------LVSV----------PEGNDISSIFELDPTTLRGGDSL 381

Query: 1366 VPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKG-WVKVICEKNRVDKETFALLPV 1542
            VPR SYVRL H  ++ WVH+TN      +    + EK   +K+     + DKE FA++PV
Sbjct: 382  VPRNSYVRLRHLCTNTWVHSTN------IPIDKEEEKPVMLKIGTSPLKEDKEAFAIVPV 435

Query: 1543 NPDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADP 1722
            +P EVRDLDFANDA K L +    ++ G +   E   S T+LL D + FVT  ++   D
Sbjct: 436  SPAEVRDLDFANDASKVLGSIAGKLEKGTITQNER-RSVTKLLEDLVYFVTGGTNSGQDV 494

Query: 1723 LKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIF 1902
            L++    P+R+RQKL+REQ +L Q+F LL+APF     T              D R+  F
Sbjct: 495  LEVVFSKPNRERQKLMREQNILKQIFKLLQAPF-----TDCGDGPMLRLEELGDQRHAPF 549

Query: 1903 KTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKY 2082
            + + +LCY +L++SQ  YRKNQE++A++FG +Q+QIG+D++AEDT+TA+LHNN KLLEK+
Sbjct: 550  RHICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKH 609

Query: 2083 VKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTK 2262
            +    ++ FV LVR NR+ +FLDYL+DLCV   ++    QELIC +VL+  + DI ++TK
Sbjct: 610  ITAAEIDTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETK 669

Query: 2263 II---------------------DGEIEVGWAPNFRKLV-----DIAEGAKSNS-DDAEH 2361
            ++                     + E+ + W  + +++      ++A+ AK    +D +
Sbjct: 670  LVLSRFEFEGVSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDAKEGQKEDRDV 729

Query: 2362 LDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSF 2541
            L YYR+QL+L ++MC ++QYLAI+         IS QL  +L+L+CMSD  LPYDLR SF
Sbjct: 730  LSYYRYQLNLFARMCLDRQYLAIN--------EISGQLDVDLILRCMSDENLPYDLRASF 781

Query: 2542 TRLMLHLHVVRG--SPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAH 2715
             RLMLH+HV R     ++ +++ARLW  IP  + +  Y+S      S  S+  I E  A
Sbjct: 782  CRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDS------SGASKDEIKERFA- 834

Query: 2716 KVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLA 2895
            + +  VE YL  +  Q          +KLT+E+VNLA+ L  F FY+F+DLL+LT+ LLA
Sbjct: 835  QTMEFVEEYLRDVVCQRFPFSDK-EKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLA 893

Query: 2896 IINEGPATEQVPSHRAMV-------NAIRN-------MSKSMMRGGNKENSKDLAKTPSV 3033
            I++    T   P  +          N +R+       M++ ++RGG       +A  P
Sbjct: 894  ILDCVHVTTIFPISKMTKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEG 953

Query: 3034 TAEEAGRTKEGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFP---------- 3183
              ++A   KE   + + TKL + EILQF+++VR DYRI+  L  FK  F
Sbjct: 954  NVKQAEPEKED-IMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQSSETS 1012

Query: 3184 ---CDEDGSLMHSASINERMASELYDAIYRSSGHE--LHLDGRDGQLLLAILLQMTMSDY 3348
                 ++G      +++     E  + I+  S     L LD   G+  L +LL +TM DY
Sbjct: 1013 SGNSSQEGPSNVPGALDFEHIEEQAEGIFGGSEENTPLDLDDHGGRTFLRVLLHLTMHDY 1072

Query: 3349 PPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELW 3528
            PPL S AL++ FRHF+Q QE+L+  KQVQLLV++ DV+NY+QI +DL  L+++ EKSELW
Sbjct: 1073 PPLVSGALQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELW 1132

Query: 3529 VHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNEC 3708
            V+  +      + +D      EH   +     P   +S  S
Sbjct: 1133 VYKGQGPD---EPMDGASGENEHKKTEEGTSKPLKHESTSSYN----------------- 1172

Query: 3709 LQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDP--KPDTMN 3882
                                           Y +++++L+RL+ +C ++     K
Sbjct: 1173 -------------------------------YRVVKEILIRLSKLCVQESASVRKSRKQQ 1201

Query: 3883 QQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFISY 4062
            Q+LL+NM  + VVLE + +P++K  D  M +++ L+HEFL++FC  N++NQ+ L+K I+
Sbjct: 1202 QRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHINL 1261

Query: 4063 EKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQ 4242
              +   G+L   T++       IF NN +L S + E ++ H V  IE + RN  +++ LQ
Sbjct: 1262 FLNP--GILEAVTMQH------IFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQ 1313

Query: 4243 ALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSDSRR 4422
             +V    K I+  Q+ V  E+  + ++V   Y D ASF+ L  MM+ E++   R  ++
Sbjct: 1314 TIVKAEGKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERD---RMDENSP 1370

Query: 4423 KLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHC 4602
               YHI LV LLA+CT GKN  TE+KC S +P+D IVRVVT + C+ EVK  Y+  L HC
Sbjct: 1371 LFMYHIHLVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHC 1430

Query: 4603 YIDTDAEMKDAYKTEYVDHILNNLLEDI-RSLRVEKLTGAETATLEHYICHTVTEVLIKF 4779
            Y+DT+ EMK+ Y + ++  +  N L DI R+           + LE Y+   V  ++  F
Sbjct: 1431 YVDTEVEMKEIYTSNHMWKLFENFLVDICRACNNTSDRKHADSVLEKYVTEIVMSIVTTF 1490

Query: 4780 FEAPYSALQQAKVDVHHHKKTFSEVLLEL--TYLEKGKLRGSKSSRNWYRVAECIKRLTK 4953
            F +P+S        +   +  F ++L  +   Y     +   K+S     V  CI+ L+
Sbjct: 1491 FSSPFS---DQSTTLQTRQPVFVQLLQGVFRVYHCNWLMPSQKAS-----VESCIRVLSD 1542

Query: 4954 WAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGHRLYGTS 5133
             A+   I +P  L        + V   + ++ +  +   +  RL+ +N       L  +
Sbjct: 1543 VAKSRAIAIPVDL-------DSQVNNLFLKSHNIVQKTAMNWRLSARNAARRDSVLAASR 1595

Query: 5134 NSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCAR 5313
            +        N++     ++   +  L PL  AE SVLV+VLH PELLFPE +  R +C
Sbjct: 1596 DYR------NIIERLQDIVSALEDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKCES 1649

Query: 5314 GGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMC-------------------------- 5415
            GG + KLI+H K L++  ++ LC +VLQTL +M
Sbjct: 1650 GGFICKLIKHTKQLLEENEEKLCIKVLQTLREMMTKDRGYGEKQISIDELENAELPQPPE 1709

Query: 5416 --DCTKQQLTHQGHRVYNSSVEKGXXXXXXXXXXYFGHHNNHHPPLDRQQSXXXXXXXXX 5589
              + T+Q+L            ++G          Y+G+      P  R++S
Sbjct: 1710 AENSTEQELEPSPPLRQLEDHKRGEALRQILVNRYYGNIR----PSGRRESLTSFGNGPL 1765

Query: 5590 XXX-------------XXXTWSQERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAI 5730
                               T   E  L  +QC L+  GAS+LV D+I+   S  +F ++I
Sbjct: 1766 SPGGPSKPGGGGGGPGSGSTSRGEMSLAEVQCHLDKEGASNLVIDLIMNASSDRVFHESI 1825

Query: 5731 HLARALLHEGNDKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRLKSDM-MSCSDSKPK 5907
             LA ALL  GN  +QHSF+ R+ +    E FFK    R++ AQ  +K+ + ++ SD   K
Sbjct: 1826 LLAIALLEGGNTTIQHSFFCRLTEDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNK 1885

Query: 5908 VSSTVL---TPLIDAGDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQ--- 6069
                 +    P              EV  Q+   S +     +     + PD   YQ
Sbjct: 1886 KKDDEVDRDAPSRKKAKEPTTQITEEVRDQLLEASAATRKAFTTFRREADPD-DHYQSGE 1944

Query: 6070 ------DEEKSTDALPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETL 6231
                  D+ K    +   + +++PILR LQLLCENHN  LQNFLR Q+++TN+NLV ETL
Sbjct: 1945 GTQATTDKAKDDLEMSAVITIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETL 2004

Query: 6232 SFLDTVCGSTKGSLGVFG-EIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQE-NGLN 6405
             FLD +CGST G LG+ G  I E N +LI QTL +LTE+CQGPCHENQN +A  E NG++
Sbjct: 2005 QFLDCICGSTTGGLGLLGLYINEKNVALINQTLESLTEYCQGPCHENQNCIATHESNGID 2064

Query: 6406 IIISLVLNEIKPLADDHMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPK 6585
            II +L+LN              +I     K +  ++E           L+N A+     K
Sbjct: 2065 IITALILN--------------DINPLGKKRMDLVLE-----------LKNNAS-----K 2094

Query: 6586 QLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGI 6765
             L+  ++  ++  N+   +     ++L      ++ KK+  Q  V
Sbjct: 2095 LLLAIMESRHDSENAERILYNMRPKELV-----EVIKKAYMQGEVE-------------- 2135

Query: 6766 VSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKKD 6945
                         +D  N +D  +  PR VGHNIYILAHQLA H+ EL+  L    +
Sbjct: 2136 ------------FEDGENGED-GAASPRNVGHNIYILAHQLARHNKELQTMLKPGGQVDG 2182

Query: 6946 DLTREALNYYKERTAQIEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSK 7125
            D   EAL +Y + TAQIEIVR DRT+E++VFP+  IC +LTK++K  +Y  TERD QGSK
Sbjct: 2183 D---EALEFYAKHTAQIEIVRLDRTMEQIVFPVPSICEFLTKESKLRIYYTTERDEQGSK 2239

Query: 7126 VTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPE 7305
            + +FF   E +++EM WQ+KL+ +  L WCA  +  W+ +SF+ A ++N LVA +YP
Sbjct: 2240 INDFFLRSEDLFNEMNWQKKLRAQPVLYWCARNMSFWSSISFNLAVLMNLLVAFFYPFKG 2299

Query: 7306 HSNSSIS---LGNLYSWFAVFSSFLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTL 7476
                ++     G L++   +  + ++A    H                       +G+
Sbjct: 2300 VRGGTLEPHWSGLLWTAMLISLAIVIALPKPHG-------IRALIASTILRLIFSVGLQP 2352

Query: 7477 TLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMI 7656
            TL++ G   + NKI+ +++FV N G   R    ++      Y L+YL IC +GL VH
Sbjct: 2353 TLFLLGAFNVCNKIIFLMSFVGNCGTFTRGYRAMVLDVEFLYHLLYLLICAMGLFVHEFF 2412

Query: 7657 YCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVD 7836
            Y +LLFD+++ EETL NVI SVTRN + I+ T  LALIL+Y FSI+G+L+F+ DF LEVD
Sbjct: 2413 YSLLLFDLVYREETLLNVIKSVTRNGRPIILTAALALILVYLFSIVGYLFFKDDFILEVD 2472

Query: 7837 PVENDSS------ATISSGIPSETC---PSEGCPGLQPSXXXX---XXXXXXXXSCETLW 7980
             + N+++      +  +  + S+ C     E C    P                +CETL
Sbjct: 2473 RLPNETAGPETGESLANDFLYSDVCRVETGENCTSPAPKEELLPVEETEQDKEHTCETLL 2532

Query: 7981 MCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTXXXXXXXXXXXXXXXXXXDT 8160
            MCI+     GLR+GGG+GDVLR P+  E +F  RV YD+                   DT
Sbjct: 2533 MCIVTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVIYDLLFFFMVIIIVLNLIFGVIIDT 2592

Query: 8161 FGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLYYIVMLQIKD 8340
            F DLR+EK +KE+ILK  CFICGL+R +FDN++VTFE H + EHN+WHYL +IV++++KD
Sbjct: 2593 FADLRSEKQKKEEILKTTCFICGLERDKFDNKTVTFEEHIKEEHNMWHYLCFIVLVKVKD 2652

Query: 8341 ETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLLQMMTLMREI 8520
             TE+TGPESYVA+ +++RNLDWFPRM+A+SL  S+ + +Q+E++ ++++L   M L+  +
Sbjct: 2653 STEYTGPESYVAEMIRERNLDWFPRMRAMSLVSSDSEGEQNELRNLQEKLESTMKLVTNL 2712

Query: 8521 ISQNEESRAFMEQ 8559
              Q  E +  M +
Sbjct: 2713 SGQLSELKDQMTE 2725


>gi|1362832|pir||A55713 inositol 1,4,5-triphosphate receptor type 1 -
            human
          Length = 2713

 Score = 1639 bits (4244), Expect = 0.0
 Identities = 1068/2929 (36%), Positives = 1571/2929 (53%), Gaps = 112/2929 (3%)
 Frame = +1

Query: 109  LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
            LHIGDI SLY E S+N    GF+STLGLVDDRC+V+ + G   +PPKKFRDCLFK+CP+N
Sbjct: 9    LHIGDICSLYAEGSTN----GFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKLCPMN 64

Query: 289  RYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQ 468
            RY+AQK  W   K     +S  D  L+NKL  AAD E+++NE+E +K LG VIQYG+++Q
Sbjct: 65   RYSAQKQFWKAAK--PGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQ 122

Query: 469  LLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKI 648
            LLH+KSNKY+TV K  PA  E+NAM+V LD AGNEGSWF I+P YK  +IGD+V  G+K+
Sbjct: 123  LLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGDKV 182

Query: 649  SLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSV 828
             L P       AG     LH SS  L+D+    EVN +N  T W++ +F+ + +N+ + +
Sbjct: 183  VLNP-----VNAGQ---PLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDIL 234

Query: 829  KSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTN 1008
            K GDVVRLFHA+Q+ FLT D   K+      VFLR T R SA  ATSS+ALWEV+VVQ +
Sbjct: 235  KGGDVVRLFHAEQEKFLTCDEHRKKQH----VFLRTTGRQSATSATSSKALWEVEVVQHD 290

Query: 1009 AYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRPPLLSALSQKSRPMLERTNN 1188
              RGG   WN  +RFKHLAT  YL+AE      +  +  +P +       SR  L
Sbjct: 291  PCRGGAGYWNSLFRFKHLATGHYLAAEVDPDFEEECLEFQPSV-DPDQDASRSRLRNAQE 349

Query: 1189 PMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPE-EDANLLFQLDPSTFMKSNKE 1365
             M +YS                 + SV          PE  D + +F+LDP+T    +
Sbjct: 350  KM-VYS-----------------LVSV----------PEGNDISSIFELDPTTLRGGDSL 381

Query: 1366 VPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKG-WVKVICEKNRVDKETFALLPV 1542
            VPR SYVRL H  ++ WVH+TN      +    + EK   +K+     + DKE F ++PV
Sbjct: 382  VPRNSYVRLRHLCTNTWVHSTN------IPIDKEEEKPVMLKIGTSPVKEDKEAFGIVPV 435

Query: 1543 NPDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADP 1722
            +P EVRDLDFANDA K L +    ++ G +   E   S T+LL D + FVT  ++   D
Sbjct: 436  SPAEVRDLDFANDASKVLGSIAGKLEKGTITQNER-RSVTKLLEDLVYFVTGGTNSGQDV 494

Query: 1723 LKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIF 1902
            L++    P+R+RQKL+REQ +L Q+F LL+APF     T              D R+  F
Sbjct: 495  LEVVFSKPNRERQKLMREQNILKQIFKLLQAPF-----TDCGDGPMLRLEELGDQRHAPF 549

Query: 1903 KTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKY 2082
            + + +LCY +L++SQ  YRKNQE++A++FG +Q+QIG+D++AEDT+TA+LHNN KLLEK+
Sbjct: 550  RHICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKH 609

Query: 2083 VKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTK 2262
            +    ++ FV LVR NR+ +FLDYL+DLCV   ++    QELIC +VL+  + DI ++TK
Sbjct: 610  ITAAEIDTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETK 669

Query: 2263 II----------------------DGEIEVGWAPNFRKLV-----DIAEGAKSNS-DDAE 2358
            ++                      + E+ + W  + +++      ++A+ AK    +D +
Sbjct: 670  LVLSRFEFEGVSSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDAKEGQKEDRD 729

Query: 2359 HLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGS 2538
             L YYR+QL+L ++MC ++QYLAI+         IS QL  +L+L+CMSD  LPYDLR S
Sbjct: 730  VLSYYRYQLNLFARMCLDRQYLAIN--------EISGQLDVDLILRCMSDENLPYDLRAS 781

Query: 2539 FTRLMLHLHVVRG--SPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIA 2712
            F RLMLH+HV R     ++ +++ARLW  IP  + +  Y+S      S  S+  I E  A
Sbjct: 782  FCRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDS------SGASKDEIKERFA 835

Query: 2713 HKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLL 2892
             + +  VE YL  +  Q          +KLT+E+VNLA+ L  F FY+F+DLL+LT+ LL
Sbjct: 836  -QTMEFVEEYLRDVVCQRFPFSDK-EKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILL 893

Query: 2893 AIINEGPATEQVPSHRAMV-------NAIRN-------MSKSMMRGGNKENSKDLAKTPS 3030
            AI++    T   P  +          N +R+       M++ ++RGG       +A  P
Sbjct: 894  AILDCVHVTTIFPISKMAKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPE 953

Query: 3031 VTAEEAGRTKEGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVF---------- 3180
               ++A   KE   + + TKL + EILQF+++VR DYRI+  L  FK  F
Sbjct: 954  GNVKQAEPEKED-IMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFWMKAIPRTSE 1012

Query: 3181 ----PCDEDGSLMHSASINERMASELYDAIYRSSGHE--LHLDGRDGQLLLAILLQMTMS 3342
                   ++G      +++     E  + I+  S     L LD   G+  L +LL +TM
Sbjct: 1013 TSSGNSSQEGPSNVPGALDFEHIEEQAEGIFGGSEENTPLDLDDHGGRTFLRVLLHLTMH 1072

Query: 3343 DYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSE 3522
            DYPPL S AL++ FRHF+Q QE+L+  KQVQLLV++ DV+NY+QI +DL  L+++ EKSE
Sbjct: 1073 DYPPLVSGALQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSE 1132

Query: 3523 LWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRN 3702
            LWV+  +      + +D      EH   +     P+  +S  S
Sbjct: 1133 LWVYKGQGPD---ETMDGASGENEHKKTEEGNNKPQKHESTSSYN--------------- 1174

Query: 3703 ECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDP--KPDT 3876
                                             Y +++++L+RL+ +C ++     K
Sbjct: 1175 ---------------------------------YRVVKEILIRLSKLCVQESASVRKSRK 1201

Query: 3877 MNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFI 4056
              Q+LL+NM  + VVLE + +P++K  D  M +++ L+HEFL++FC  N++NQ+ L+K I
Sbjct: 1202 QQQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHI 1261

Query: 4057 SYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLEL 4236
            +   +   G+L   T++       IF NN +L S + E ++ H V  IE + RN  +++
Sbjct: 1262 NLFLNP--GILEAVTMQH------IFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKF 1313

Query: 4237 LQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSDS 4416
            LQ +V    K I+  Q+ V  E+  + ++V   Y D ASF+ L  MM+ E++      D
Sbjct: 1314 LQTIVKAEGKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERDRM----DE 1369

Query: 4417 RRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLL 4596
               L YHI LV LLA+CT GKN  TE+KC S +P+D IVRVVT + C+ EVK  Y+  L
Sbjct: 1370 NSPLMYHIHLVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLN 1429

Query: 4597 HCYIDTDAEMKDAYKTEYVDHILNNLLEDI-RSLRVEKLTGAETATLEHYICHTVTEVLI 4773
            HCY+DT+ EMK+ Y + ++  ++ N L DI R+           + LE Y+   V  ++
Sbjct: 1430 HCYVDTEVEMKEIYTSNHMWKLVENFLVDICRACNNTSDRKHADSILEKYVTEIVMSIVT 1489

Query: 4774 KFFEAPYSALQQAKVDVHHHKKTFSEVLLEL--TYLEKGKLRGSKSSRNWYRVAECIKRL 4947
             FF +P+S        +   +  F ++L  +   Y     +   K+S     V  CI+ L
Sbjct: 1490 TFFSSPFS---DQSTTLQTRQPVFVQLLQGVFRVYHCNWLMPSQKAS-----VESCIRVL 1541

Query: 4948 TKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGHRLYG 5127
            +  A+   I +P  L        + V   + ++ S  +   +  RL+ +N       L
Sbjct: 1542 SDVAKSRAIAIPVDL-------DSQVNNLFLKSHSIVQKTAMNWRLSARNAARRDSVLAA 1594

Query: 5128 TSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQC 5307
            + +        N++     ++   +  L PL  AE SVLV+VLH PELLFPE +  R +C
Sbjct: 1595 SRDYR------NIIERLQDIVSALEDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKC 1648

Query: 5308 ARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKQQLTHQGHRVYNSSVEKGXX 5487
              GG + KLI+H K L++  ++ LC +VLQTL +M   TK        R Y    EKG
Sbjct: 1649 ESGGFICKLIKHTKQLLEENEEKLCIKVLQTLREMM--TKD-------RGYG---EKGEA 1696

Query: 5488 XXXXXXXXYFGHHNNHHPPLDRQQSXXXXXXXXXXX------------XXXXTWSQ-ERD 5628
                    Y+G+      P  R++S                           + S+ E
Sbjct: 1697 LRQVLVNRYYGNVR----PSGRRESLTSFGNGPLSAGGPGKPGGGGGGSGSSSMSRGEMS 1752

Query: 5629 LYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKD 5808
            L  +QC L+  GAS+LV D+I+   S  +F ++I LA ALL  GN  +QHSF+ R+ +
Sbjct: 1753 LAEVQCHLDKEGASNLVIDLIMNVSSDRVFHESILLAIALLEGGNTTIQHSFFCRLTEDK 1812

Query: 5809 IHEPFFKAILTRIQTAQNRLKSDM-MSCSDSKPKVSSTVL---TPLIDAGDTGFNGALFE 5976
              E FFK    R++ AQ  +K+ + ++ SD   K     +    P              E
Sbjct: 1813 KSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPTTQITEE 1872

Query: 5977 VPQQVRHPSISEMSQLSNDLTHSIPDLAPYQ---------DEEKSTDALPPEVALVEPIL 6129
            V  Q+   S +     +     + PD   YQ         D+ K    +   + +++PIL
Sbjct: 1873 VRDQLLEASAATRKAFTTFRREADPD-DHYQPGEGTQATADKAKDDLEMSAVITIMQPIL 1931

Query: 6130 RVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFG-EIGEHNF 6306
            R LQLLCENHN  LQNFLR Q+++TN+NLV ETL FLD +CGST G LG+ G  I E N
Sbjct: 1932 RFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINEKNV 1991

Query: 6307 SLITQTLATLTEFCQGPCHENQNTMAMQE-NGLNIIISLVLNEIKPLADDHMELALEIKS 6483
            +LI QTL +LTE+CQGPCHENQN +A  E NG++II +L+LN              +I
Sbjct: 1992 ALINQTLESLTEYCQGPCHENQNCIATHESNGIDIITALILN--------------DINP 2037

Query: 6484 QASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRD 6663
               K +  ++E           L+N A+     K L+  ++  ++  N+   +     ++
Sbjct: 2038 LGKKRMDLVLE-----------LKNNAS-----KLLLAIMESRHDSENAERILYNMRPKE 2081

Query: 6664 LFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVD 6843
            L      ++ KK+  Q  V                            +D  N +D  +
Sbjct: 2082 LV-----EVIKKAYMQGEVE--------------------------FEDGENGED-GAAS 2109

Query: 6844 PREVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTL 7023
            PR VGHNIYILAHQLA H+ EL+  L    +   D   EAL +Y + TAQIEIVR DRT+
Sbjct: 2110 PRNVGHNIYILAHQLARHNKELQSMLKPGGQVDGD---EALEFYAKHTAQIEIVRLDRTM 2166

Query: 7024 ERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKW 7203
            E++VFP+  IC +LTK++K  +Y  TERD QGSK+ +FF   E +++EM WQ+KL+ +
Sbjct: 2167 EQIVFPVPSICEFLTKESKLRIYYTTERDEQGSKINDFFLRSEDLFNEMNWQKKLRAQPV 2226

Query: 7204 LSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSIS---LGNLYSWFAVFSSFLL 7374
            L WCA  +  W+ +SF+ A ++N LVA  YPL      ++     G L++   +    ++
Sbjct: 2227 LYWCARNMSFWSSISFNLAVLMNLLVAFLYPLKGVRGGTLEPHWSGLLWTGMLISLGIVI 2286

Query: 7375 AHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVAFVSNKGL 7554
                 H                       +G    L++ G   +  KI+ +++FV N G
Sbjct: 2287 GLPNPHG-------IRALIGSTILRLIFSVGSQPALFLLGAFNVCKKIIFLMSFVGNCGT 2339

Query: 7555 EDRPIAEILACRNLHYL--LVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTR 7728
              R    ++   ++ +L  L+YL IC +GL VH   Y +LL D+++ EE+L NVI SVTR
Sbjct: 2340 FTRGYRAMVLVLDVEFLYHLLYLVICAMGLFVHVFFYSLLLLDLVYREESLLNVIKSVTR 2399

Query: 7729 NYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSS------ATISSGIPSET 7890
            N +SI+ T +LALIL+Y FSI+G+L+F+ DF LEVD + N+++      +  S  + S+
Sbjct: 2400 NGRSIILTAVLALILVYLFSIVGYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDV 2459

Query: 7891 C---PSEGCPGLQPSXX---XXXXXXXXXXSCETLWMCILQTGYQGLRNGGGIGDVLRNP 8052
            C     E C    P                +CETL MCI+     GLR+GGG+GDVLR P
Sbjct: 2460 CRVESGENCSSPAPREELVPAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKP 2519

Query: 8053 APWEDMFIWRVAYDMTXXXXXXXXXXXXXXXXXXDTFGDLRAEKNEKEQILKNNCFICGL 8232
            +  E +F  RV YD+                   DTF DLR+EK +KE+ILK  CFICGL
Sbjct: 2520 SKEEPLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGL 2579

Query: 8233 DRSRFDNRSVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFP 8412
            +R +FDN++VTFE H + EHN+WHYL +IV++++KD TE+TGPESYVA+ +K+RNLDWFP
Sbjct: 2580 ERDKFDNKTVTFEEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFP 2639

Query: 8413 RMQALSLQDSELDTDQSEVKQMKDQLLQMMTLMREIISQNEESRAFMEQ 8559
            RM+A+SL  S+ + +Q+E++ ++++L   M L+  +  Q  E +  M +
Sbjct: 2640 RMRAMSLVSSDSEGEQNELRNLQEKLESTMKLVTNLSGQLSELKDQMTE 2688


>gi|7522013|pir||T31431 inositol 1,4,5-trisphosphate receptor,
            localized in plasma membrane - Panulirus argus
 gi|3660667|gb|AAC61691.1| inositol 1,4,5-trisphosphate receptor
            [Panulirus argus]
          Length = 2783

 Score = 1634 bits (4230), Expect = 0.0
 Identities = 1074/2979 (36%), Positives = 1568/2979 (52%), Gaps = 155/2979 (5%)
 Frame = +1

Query: 94   GNNGNLHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFK 273
            G+   LH+GDI+SLY E S +    GF+STLGLVD RC+V  + G   +PPKKFRDCLF
Sbjct: 5    GSASFLHMGDIVSLYAEGSVS----GFISTLGLVDARCVVNPEAGDLSTPPKKFRDCLFS 60

Query: 274  VCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQY 453
            +CP NRY+AQK  W   K   +G+S  D  L+N+L  AA  E+ +NE+E +K +G VI Y
Sbjct: 61   ICPSNRYSAQKQFWKAAKH--SGNSTTDPSLLNRLHDAAKTEKRQNEAESKKLMGTVINY 118

Query: 454  GSMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVS 633
            G  +QLLH+KSNKY+TV K  PA  E+NAM+VYLD  GNEGSWF I P YK    GDNV
Sbjct: 119  GITIQLLHLKSNKYLTVNKRLPALLEKNAMRVYLDANGNEGSWFYINPYYKLRNPGDNVV 178

Query: 634  AGNKISLIPNSVSTTQAGHVKSQLHLSS-FNLLDHQSAAEVNCLNEPTEWQVFMFLLFDE 810
             G+K+ L P       AG    QLH+SS  +L DH    EVN LN  T W++ +FL   E
Sbjct: 179  VGDKVILSP-----VNAGQ---QLHVSSTHDLRDHPGCKEVNVLNSNTCWKISLFLEHKE 230

Query: 811  NQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEV 990
            N +  +K GDV+RLFHA+Q+ FLT+D   K+      VFLR T R +A  ATSS+ALWEV
Sbjct: 231  NLEGVLKGGDVIRLFHAEQEKFLTMDEYKKKQH----VFLRTTGRTTATAATSSKALWEV 286

Query: 991  QVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRPPLLSALSQKSRPM 1170
            +VVQ +  RGG   WN  +RFKHLAT  YL+AE
Sbjct: 287  EVVQHDPSRGGAGHWNSLFRFKHLATGHYLAAEIDD------------------------ 322

Query: 1171 LERTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANLLFQLDPSTFM 1350
             + T +P       PNG             P   ++    S     D   +F+L+P+T +
Sbjct: 323  -DPTPDPTRTKLRDPNGG------------PVYQLVSVPLSN----DIASIFELEPTTLI 365

Query: 1351 KSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWVKVICEKNRVDKETFA 1530
            + +  VP+ SYVRL H  +  WVH+T+    +      +++    KV C   + DKE F+
Sbjct: 366  RGDSMVPQSSYVRLRHLCTSTWVHSTSIPIDKE-----EDKPVMSKVGCAPIKEDKEAFS 420

Query: 1531 LLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVT----- 1695
            L+PV+  EVRDLDFA+DA + L    K ++ G +   E   S   LL+D + F
Sbjct: 421  LVPVHAKEVRDLDFAHDASEVLAKHAKKLEKGSITQAER-RSLMLLLLDLLYFTAEKEHE 479

Query: 1696 -NSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXX 1872
             N S+ LA  L++++  P+RDRQKLLREQ +L Q+F +L+APF   QG
Sbjct: 480  QNKSESLALALEVTN--PNRDRQKLLREQSILKQIFKILRAPFTETQG---GDGPLLRID 534

Query: 1873 XXXDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVL 2052
               D R+  +K +F+LCY LL+ +Q  YRKNQE +A+ FG +Q+QIG D++AE+T+TA+L
Sbjct: 535  ELNDPRHSAYKNIFRLCYRLLRLAQQGYRKNQEHIAQHFGFMQKQIGIDILAEETITALL 594

Query: 2053 HNNPKLLEKYVKTPHVERFVELVRNNRQG---KFLDYLADLCVCRGEANKKIQELICTSV 2223
            HNN KLLE ++    +E FV LVR N      +FLDYL  LC+   +A  + QELIC SV
Sbjct: 595  HNNRKLLEIHITATEIETFVGLVRKNMHKWDWRFLDYLKVLCISNNQAIPRTQELICKSV 654

Query: 2224 LSSKHRDIFMDTKIIDGEIEV-----GWAPNF------------------RKLVDIAEGA 2334
             S K++DI ++T++++ +IEV     G  P                    + +V++A  A
Sbjct: 655  FSEKNKDILIETRLVEEDIEVEVNVEGSCPMLAIERDEEVVLTWNNGECSKSIVELASRA 714

Query: 2335 KSNSD-----DAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQC 2499
            ++ SD     D   L+YYRH LDL S MC ++QYLAI P        +S  L   L+L+C
Sbjct: 715  QNLSDSDGGEDRLILEYYRHMLDLFSNMCLDRQYLAIRP--------LSPLLKINLMLKC 766

Query: 2500 MSDNRLPYDLRGSFTRLMLHLHV--VRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAY 2673
            M +  L YDLR +F RLMLH+HV       ++ +++ARLW  I  +++++ Y+  +
Sbjct: 767  MEEETLAYDLRAAFCRLMLHMHVDCEPQEMVTPVKYARLWSEIQPHMSIADYDKHAAMHS 826

Query: 2674 SDGSRMRIGEGIAHKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFY 2853
            ++ +     +     V+  VE YL  + ++ M        +KLT+E+V LA+ L  F FY
Sbjct: 827  TEAAETTFKD-----VIVFVEEYLCNVVDK-MWSFSDCEQNKLTFEVVKLARYLIYFGFY 880

Query: 2854 SFNDLLQLTQNLLAIINEGPATEQ------VPSHRAMVNAIRNMSKSMMRGGNKENSKDL 3015
            SFNDLL+LT+ LL+I++    T+       +P   A  +A   + KS+   G    +  L
Sbjct: 881  SFNDLLRLTKTLLSILDYSFDTDSKYFSNSIPQGTA--SAKGGVIKSLGDMGAVVTNLAL 938

Query: 3016 AKTP--------SVTAEEAGRTKEGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFK 3171
              T         S   ++ G T++   L + TKL + EIL+F+++VR DYRI+  LS FK
Sbjct: 939  GTTRMGPRLGGGSSPKKKVGATEKEDTLVMDTKLKIIEILEFILNVRLDYRISCLLSIFK 998

Query: 3172 NVFPCDEDGSLMHSASINERM-----------ASELYD----------------AIYRSS 3270
                 DE+ S +    I++ +           A  ++D                ++  SS
Sbjct: 999  K--ESDENPSSLTGEGISQGLKNKNVENIWAQAQSIFDETSGLGLVWSSSQRKPSLQTSS 1056

Query: 3271 GHE---LHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLL 3441
              E   L LDG  G+  L +LL +TM +YPPL S +L++ FRHF+Q QE+L++ KQVQLL
Sbjct: 1057 CEENSSLDLDGEGGKKFLRVLLHLTMHEYPPLVSRSLQLLFRHFSQRQEVLQNFKQVQLL 1116

Query: 3442 VSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLK 3621
            V + DVE+Y+QI  D   L+NL EKSELWV+  R    D     +K++  + D  D  L
Sbjct: 1117 VQDGDVESYKQIKEDSDDLRNLVEKSELWVYKSRSTDEDGGGTKKKKKKNKDDDEDDALS 1176

Query: 3622 SPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIA 3801
             P+   +                             L   D+ ++A+ L       P  A
Sbjct: 1177 KPKKPPAPK---------------------------LTAQDKQESAIDLGLGPPLEPEQA 1209

Query: 3802 --YPLIRQMLVRLTGMCYRK---GDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHD 3966
              Y  I+Q+LVR+  +C  +   G+  P    Q+LL+NM ++ VVLE + +P+D+K D
Sbjct: 1210 DNYKRIQQILVRMNKLCVTQSSHGNLSPKRNEQRLLRNMGIHSVVLELLQIPYDRKEDKR 1269

Query: 3967 MMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNR 4146
            M +LI L+H+FL++FC  ++ NQ+ LYK  S +     G+L  +T+       A+F++N
Sbjct: 1270 MNELIELAHQFLQNFCLGDRANQALLYK--SIDLFLNPGLLEAKTV------CAVFKDNS 1321

Query: 4147 ELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEV 4326
             L S V E +I H +  IE + R+  +L+ LQ +V    + +   Q+ V  E+  A ++V
Sbjct: 1322 HLCSEVSERVIQHFIHCIETHGRHVQYLKFLQTIVKAEGQFLRRSQDIVMQELVNAGEDV 1381

Query: 4327 RQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCA 4506
               Y + ASF     MMK ++       D    L+YHIELV+LLA CT GKN +TE+KC
Sbjct: 1382 LVFYNERASFNMFIEMMKADRNRM--DFDDSSPLRYHIELVKLLACCTEGKNASTEIKCH 1439

Query: 4507 SQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNN--LLE 4680
            S +P+D IV +V  K C+ EVK  Y+  L HCYIDT+ EMK+ Y + ++  +     L++
Sbjct: 1440 SLLPLDDIVAMVEHKDCIPEVKEAYINFLNHCYIDTEVEMKEIYNSHHIWSLFEKSFLVD 1499

Query: 4681 DIRSLRVEKLTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLL 4860
              R              LE+Y+ +++  ++  FF +P+S   Q    +   +  F + LL
Sbjct: 1500 MGRVATAPPDRRHADKALENYVINSLMTIITTFFNSPFSDQSQT---IQTRQPVFVQ-LL 1555

Query: 4861 ELTYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQ 5040
               Y     + G +       V  CIK LT+ A +HNI++P  L    +S   S R
Sbjct: 1556 HAVYRVSQAVMGHQR----VNVENCIKTLTEVARKHNISIPVDLEAQVVS--MSQRTTSI 1609

Query: 5041 QAASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVV-TCYHMMIGEFKFYLHP 5217
               +++KW             N   R   +S+S++      V+   ++ ++   +  L P
Sbjct: 1610 MTRTASKW------------SNRATRRDASSSSLSGRMDHLVIEQDFNSVVSVLEAELRP 1657

Query: 5218 LHAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQ 5397
            L AAE SVLV++L+ P  LF   S    +C  GG +++LI+HC+ L++ + + LC +VL+
Sbjct: 1658 LVAAELSVLVDILYQPHRLFRPDSEASIKCKNGGFISRLIRHCEKLLEEEDEKLCIQVLK 1717

Query: 5398 TLCKMCDCTKQQLTHQGHRVYNSSVEKGXXXXXXXXXXYFGHHNNHHPPLDRQQSXXXXX 5577
            TL       K  +T   +       EKG          YF  +     P  ++++
Sbjct: 1718 TL-------KDMITDSEYG------EKGDALRNLLLTRYFDQY-----PWSKKEAAELRA 1759

Query: 5578 XXXXXXXXXXTWSQE--RDLYAIQCKLNDAGASDLVTDIIIMEPSR-EIFLKAIHLARAL 5748
                         +   + L  +QC L   GA++LV D+++   +R  IF++A+ L  A
Sbjct: 1760 RQPQNVGPGDVVQRRSGKSLSEVQCDLAKKGAANLVVDLVMKSQNRHRIFVEAVELGIAP 1819

Query: 5749 LHEGNDKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRLKSDM-MSCSDSKPKVSSTVL 5925
            L  GN  +Q   Y ++++ D  + FFK    +++ AQ  +++ + ++ SD   K S
Sbjct: 1820 LEGGNRDIQDMLYTKLQESDTSQNFFKVFDNKMEEAQQEIRNTVTVNTSDLSAKSSDEKD 1879

Query: 5926 TP----LIDAGDTGFNGALFEVPQQVRHPSISEMSQLSNDLT-----------------H 6042
             P     ++    G       +  ++R       S  S   T                 +
Sbjct: 1880 GPKEGEKLNRKKGGHKPNGLVMNDEIREELSVAASVTSQAYTNIRAGSTGDDNNSCLGLN 1939

Query: 6043 SIPDLAPYQDEEKSTDA------LPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRT 6204
            ++ ++        + DA      L P++ ++EP+LR LQLLCENHN  LQ FLR Q  +T
Sbjct: 1940 TLEEVGENYGGRSNKDANADNPKLSPKITVMEPVLRFLQLLCENHNLYLQIFLRNQKSKT 1999

Query: 6205 NHNLVSETLSFLDTVCGSTKGSLGVFG-EIGEHNFSLITQTLATLTEFCQGPCHENQNTM 6381
            N+NLVS+TL FLD +CGST G LG+ G  I EHN SLI QTL TLTE+CQGPCHENQN +
Sbjct: 2000 NYNLVSKTLMFLDCICGSTTGGLGLLGLYINEHNVSLINQTLETLTEYCQGPCHENQNCI 2059

Query: 6382 AMQE-NGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIMESRHDGENANRVLRN 6558
            A  E NGL+II +L+L++I PLA   M+L LE+K+ ASKLLLAIMESR D ENA R+L++
Sbjct: 2060 ATHESNGLHIITALILSDINPLAKARMDLVLELKNNASKLLLAIMESRADSENAERILQS 2119

Query: 6559 MANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLP 6738
            M             I Q  ++  + +H       + F     D
Sbjct: 2120 M------------HIDQLLDVVCNLYHQESMDDDEFFEDGSSD----------------- 2150

Query: 6739 EINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNIYILAHQLAIHDGELEIW 6918
                                  DD         V P+EVGHNIYIL HQLA H   LE
Sbjct: 2151 ----------------------DD--------GVSPKEVGHNIYILCHQLAKHHKGLEEL 2180

Query: 6919 LDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNN 7098
            L  S  +K     +AL +Y+E TAQIEIVR DRT+E++VFPI +IC+YLTK+TK  VYN
Sbjct: 2181 LSKSGNEK---LSKALTHYRENTAQIEIVRSDRTMEQIVFPIPEICNYLTKETKQRVYNT 2237

Query: 7099 TERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNAL 7278
             ERD QG+KVT+FF++   M+ EM WQ+KL+ +  LS  +  + LW+RL F  A +VN +
Sbjct: 2238 AERDEQGTKVTDFFEKCNDMFIEMQWQKKLKSQAVLSTISNYMSLWSRLLFLLALMVNLI 2297

Query: 7279 VARYYPLPEH-SNSSISLGNLYSWFAVFSSFLLAHYLRHDKIYLHKTXXXXXXXXXXXXX 7455
            VA +YP   H  N S  L  L     +    ++  + +   IYL
Sbjct: 2298 VALFYPYTSHLPNISGHLNGLLWVVLLIGLAIVVSFQQQIFIYL------LGSISVVRLI 2351

Query: 7456 XXIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRNLHYLLVYLFICILG 7635
              +G   TL++ G   ++ K +H+V+ + NKG   + + + +    L Y ++YL  C+LG
Sbjct: 2352 FSVGPEPTLWLLGSANVLIKGIHLVSLMGNKGTFAKRLEQQVTDGELLYHVIYLVFCVLG 2411

Query: 7636 LLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALILLYFFSILGFLYFRH 7815
            L VHP  Y +LLFD+++ EETL NVI SVTRN  SI+ T  LALIL+Y FSI+G+++FR+
Sbjct: 2412 LSVHPFCYSVLLFDVVYREETLLNVIRSVTRNGWSIILTAALALILVYMFSIIGYMFFRN 2471

Query: 7816 DFYLEV-------DPVENDSSATISSGIPSE----------------TCPSEGCPGLQ-- 7920
            DF ++V       D ++   +  I S + +                  C  E    L
Sbjct: 2472 DFIVDVTDNDIDWDTIQKHINQRIESYVTTSLSVKKNSVEDTCEMGVDCTEEDSSNLYNV 2531

Query: 7921 ----PSXXXXXXXXXXXXSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVA 8088
                              +C TL MCI+ +   GLR+GGGIGD+LR P+  E++F  RV
Sbjct: 2532 VDSITKEVMVEVEDAKEEACSTLLMCIVTSLNHGLRSGGGIGDILRAPSNKENLFAARVI 2591

Query: 8089 YDMTXXXXXXXXXXXXXXXXXXDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTF 8268
            YD+                   DTF DLR+EK   E+ILKN+CFICGL RS FDN++V F
Sbjct: 2592 YDLLFFFVVIIIVLNLIFGVIIDTFADLRSEKQNSEEILKNSCFICGLTRSSFDNKAVNF 2651

Query: 8269 ETHRETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSEL 8448
            E H + EHN+WHYLY+ V + +KD TEFTGPESYV   VK+++L+WFPRM+A+SL   E
Sbjct: 2652 EDHIKREHNMWHYLYFYVQVNVKDPTEFTGPESYVYLLVKEKDLNWFPRMRAMSLSIGET 2711

Query: 8449 DTDQSEVKQMKDQLLQMMTLMREIISQNEESRAFMEQFQ 8565
            + + +EV+ +  +L +   L+  ++ Q  E +  M + Q
Sbjct: 2712 EGEMNEVRCLNAKLDRTQALVDSLVYQLTELKDEMTKQQ 2750


>gi|4504793|ref|NP_002214.1| inositol 1,4,5-triphosphate receptor,
            type 2 [Homo sapiens]
 gi|2833252|sp|Q14571|IP3S_HUMAN Inositol 1,4,5-trisphosphate receptor
            type 2 (Type 2 inositol 1,4,5-trisphosphate receptor)
            (Type 2 InsP3 receptor) (IP3 receptor isoform 2)
            (InsP3R2)
 gi|450469|dbj|BAA05384.1| type 2 inositol 1,4,5-trisphosphate
            receptor [Homo sapiens]
          Length = 2701

 Score = 1627 bits (4214), Expect = 0.0
 Identities = 1052/2912 (36%), Positives = 1562/2912 (53%), Gaps = 95/2912 (3%)
 Frame = +1

Query: 109  LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
            L+IGDI+SLY E S N    GF+STLGLVDDRC+V  + G   +PPKKFRDCLFKVCP+N
Sbjct: 9    LYIGDIVSLYAEGSVN----GFISTLGLVDDRCVVHPEAGDLANPPKKFRDCLFKVCPMN 64

Query: 289  RYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQ 468
            RY+AQK  W  ++  Q   +  +  L+ KL+ AA+ E+++NESE +K LG +++Y +++Q
Sbjct: 65   RYSAQKQYWKAKQAKQGNHT--EAALLKKLQHAAELEQKQNESENKKLLGEIVKYSNVIQ 122

Query: 469  LLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKI 648
            LLH+KSNKY+TV K  PA  E+NAM+V LD AGNEGSWF I P +K  + GDN+  G+K+
Sbjct: 123  LLHIKSNKYLTVNKRLPALLEKNAMRVSLDAAGNEGSWFYIHPFWKLRSEGDNIVVGDKV 182

Query: 649  SLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSV 828
             L+P       AG     LH S+  LLD+    EVN +N  T W++ +F+ +   +++ +
Sbjct: 183  VLMP-----VNAGQ---PLHASNIELLDNPGCKEVNAVNCNTSWKITLFMKYSSYREDVL 234

Query: 829  KSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTN 1008
            K GDVVRLFHA+Q+ FLT D   K+      +FLR T R SA  ATSS+ALWE++VV  +
Sbjct: 235  KGGDVVRLFHAEQEKFLTCDEYEKKQH----IFLRTTLRQSATSATSSKALWEIEVVHHD 290

Query: 1009 AYRGGTAKWNKAYRFKHLATDMYLSAE------PSQVQVKPAMNGRPPLLSALSQKSRPM 1170
              RGG  +WN  +RFKHLAT  YL+AE       +Q + K   +G PP     S+K R
Sbjct: 291  PCRGGAGQWNSLFRFKHLATGNYLAAELNPDYRDAQNEGKNVRDGVPPT----SKKKRQA 346

Query: 1171 LERTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANLLFQLDPSTFM 1350
             E+    +     G                                D   LF+LD +T
Sbjct: 347  GEKIMYTLVSVPHG-------------------------------NDIASLFELDATTLQ 375

Query: 1351 KSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWVKVICEKNRVDKETFA 1530
            +++  VPR SYVRL H  ++ WV +T+         + +     +K+   + + DKE FA
Sbjct: 376  RADCLVPRNSYVRLRHLCTNTWVTSTSIPID-----TDEERPVMLKIGTCQTKEDKEAFA 430

Query: 1531 LLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDH 1710
            ++ V   EVRDLDFANDA K L   +K ++ G +   E     T+LL D I FV +  ++
Sbjct: 431  IVSVPLSEVRDLDFANDANKVLATTVKKLENGTITQNER-RFVTKLLEDLIFFVADVPNN 489

Query: 1711 LADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSR 1890
              + L +    P+R+RQKL+REQ +L QVF +LKAPF  + G               D R
Sbjct: 490  GQEVLDVVITKPNRERQKLMREQNILAQVFGILKAPFKEKAGE----GSMLRLEDLGDQR 545

Query: 1891 NEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKL 2070
               +K M +LCY +L++SQ  YRKNQE++A+ F  +Q QIG+D++AEDT+T +LHNN KL
Sbjct: 546  YAPYKYMLRLCYRVLRHSQQDYRKNQEYIAKNFCVMQSQIGYDILAEDTITPLLHNNRKL 605

Query: 2071 LEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIF 2250
            LEK++    +E FV L+R NR+ +FLDYL+DLCV    A    QELIC  +LS  + DI
Sbjct: 606  LEKHITAKEIETFVSLLRRNREPRFLDYLSDLCVSNTTAIPVTQELICKFMLSPGNADIL 665

Query: 2251 MDTKII------------------DGEIEVGWA-----PNFRKLVDIAEGAKSNSD-DAE 2358
            + TK++                  D E+ + W      P+ + +  +A+ AK  +  D E
Sbjct: 666  IQTKVVSMQADNPMESSILSDDIDDEEVWLYWIDSNKEPHGKAIRHLAQEAKEGTKADLE 725

Query: 2359 HLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGS 2538
             L YYR+QL+L ++MC ++QYLAI+         IS QL  +L+L+C+SD  LP+DLR S
Sbjct: 726  VLTYYRYQLNLFARMCLDRQYLAIN--------QISTQLSVDLILRCVSDESLPFDLRAS 777

Query: 2539 FTRLMLHLHVVRGSPMSAI--RHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIA 2712
            F RLMLH+HV R    S +  R+ARLW  IP  + +  Y+S++     D SR  +    A
Sbjct: 778  FCRLMLHMHVDRDPQESVVPVRYARLWTEIPTKITIHEYDSIT-----DSSRNDMKRKFA 832

Query: 2713 HKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLL 2892
               +  VE YL  + NQ          +KLT+E+V+LA+ L  F FYSF++LL+LT+ LL
Sbjct: 833  -LTMEFVEEYLKEVVNQPFPFGDK-EKNKLTFEVVHLARNLIYFGFYSFSELLRLTRTLL 890

Query: 2893 AIIN--EGPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAK-----------TPSV 3033
            AI++  + P +          +   N+ +++   G       L++            PS+
Sbjct: 891  AILDIVQAPMSSYFERLSKFQDGGNNVMRTIHGVGEMMTQMVLSRGSIFPMSVPDVPPSI 950

Query: 3034 TAEEAGRTKEGRALNVK-TKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGS--- 3201
               + G   E   + V  TKL + EILQF++ VR DYRI+  LS +K  F  D D +
Sbjct: 951  HPSKQGSPTEHEDVTVMDTKLKIIEILQFILSVRLDYRISYMLSIYKKEFGEDNDNAETS 1010

Query: 3202 -------LMHSA---SINERMASELYDAIYRSSGHELHLDGRDGQLLLAILLQMTMSDYP 3351
                   L+ SA    I+E  A        R   + + LD   G+  L +L+ + M DY
Sbjct: 1011 ASGSPDTLLPSAIVPDIDEIAAQAETMFAGRKEKNPVQLDDEGGRTFLRVLIHLIMHDYA 1070

Query: 3352 PLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWV 3531
            PL S AL++ F+HF+Q  E+L+  KQVQLLVSN DV+NY+QI  DL  L+   EKSELWV
Sbjct: 1071 PLLSGALQLLFKHFSQRAEVLQAFKQVQLLVSNQDVDNYKQIKADLDQLRLTVEKSELWV 1130

Query: 3532 HGDRHHSIDTKEVDEKE-RTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNEC 3708
              ++  + +  E+ E + +  E  + + ++ SP
Sbjct: 1131 --EKSSNYENGEIGESQVKGGEEPIEESNILSP--------------------------- 1161

Query: 3709 LQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDPKPDTMNQQ 3888
                    ++D      +      D      Y +++++L+RL+ +C +  + K    +Q+
Sbjct: 1162 --------VQDGTKKPQI------DSNKSNKYRIVKEILIRLSKLCVQ--NKKCRNQHQR 1205

Query: 3889 LLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEK 4068
            LLKNM  + VVL+ + +P++K +D  M +++ L+H FL++FC+ N +NQ  L+K ++
Sbjct: 1206 LLKNMGAHSVVLDLLQIPYEK-NDEKMNEVMNLAHTFLQNFCRGNPQNQVLLHKHLNLF- 1263

Query: 4069 DAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQAL 4248
                G+L  ET+        IF NN  L + + E ++ H V  IE + R+  +L  LQ +
Sbjct: 1264 -LTPGLLEAETMRH------IFMNNYHLCNEISERVVQHFVHCIETHGRHVEYLRFLQTI 1316

Query: 4249 VCVYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKL 4428
            V    K ++  Q+ V  E+    ++V   Y D ASF  L  MM  E++      D    L
Sbjct: 1317 VKADGKYVKKCQDMVMTELINGGEDVLIFYNDRASFPILLHMMCSERDR----GDESGPL 1372

Query: 4429 KYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYI 4608
             YHI LV LLA CT GKN  TE+KC S +P+D IVRVVT   C+ EVK  Y+  + HCY+
Sbjct: 1373 AYHITLVELLAACTEGKNVYTEIKCNSLLPLDDIVRVVTHDDCIPEVKIAYVNFVNHCYV 1432

Query: 4609 DTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEKLTGAETAT--LEHYICHTVTEVLIKFF 4782
            DT+ EMK+ Y + ++  +  N L D+  +     T  + A   LE  +  ++  ++  FF
Sbjct: 1433 DTEVEMKEIYTSNHIWKLFENFLVDMARV-CNTTTDRKHADIFLEKCVTESIMNIVSGFF 1491

Query: 4783 EAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGKLRGSKSSRNWYRVAECIKRLTKWAE 4962
             +P+S        +  H+  F ++L     +            +   V  CI+ L + A+
Sbjct: 1492 NSPFS---DNSTSLQTHQPVFIQLLQSAFRIYNCTWPNPAQKAS---VESCIRTLAEVAK 1545

Query: 4963 EHNITLPATLAGPQMSGQTSVRQKWQQAASS-AKWIGIGKRLNRQNTLNPGHRLYGTSNS 5139
               I +P  L        + V   + ++ S+  +   +G RL+ ++       L G +
Sbjct: 1546 NRGIAIPVDL-------DSQVNTLFMKSHSNMVQRAAMGWRLSARSGPRFKEALGGPAWD 1598

Query: 5140 MTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCARGG 5319
                   N++     ++   +    P+  AE SVLV+VL++PELLFPEGS  R +C  G
Sbjct: 1599 YR-----NIIEKLQDVVASLEHQFSPMMQAEFSVLVDVLYSPELLFPEGSDARIRC--GA 1651

Query: 5320 VVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKQQLTHQGHRVYNSSVEKGXXXXXX 5499
             ++KLI H K LM+ K++ LC ++LQTL +M +              +S VE+G
Sbjct: 1652 FMSKLINHTKKLME-KEEKLCIKILQTLREMLEKK------------DSFVEEGNTLRKI 1698

Query: 5500 XXXXYFGHHNNHHPPLDRQQSXXXXXXXXXXXXXXXTWSQERDLYA--IQCKLNDAGASD 5673
                YF    ++   ++   S                 S +  +    IQC L+  GAS+
Sbjct: 1699 LLNRYF--KGDYSIGVNGHLSGAYSKTAQVGGSFSGQDSDKMGISMSDIQCLLDKEGASE 1756

Query: 5674 LVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEPFFKAILTRIQT 5853
            LV D+I+   +  IF + I L  ALL  GN + Q+SFY ++ ++   E FFK +  R++
Sbjct: 1757 LVIDVIVNTKNDRIFSEGIFLGIALLEGGNTQTQYSFYQQLHEQKKSEKFFKVLYDRMKA 1816

Query: 5854 AQNRLKSDM----MSCSDSKPKVSSTVLT--PLIDAGDT------GFNGALFEVPQQVRH 5997
            AQ  ++S +    +   + K    + ++T  P +   D+      G  G L E
Sbjct: 1817 AQKEIRSTVTVNTIDLGNKKRDDDNELMTSGPRMRVRDSTLHLKEGMKGQLTEASSATSK 1876

Query: 5998 PSISEMSQLSNDLTHSIPDLAPYQDEEKSTD--ALPPEVALVEPILRVLQLLCENHNSLL 6171
                   ++  ++            EEKS +   + P +A+++PILR LQLLCENHN  L
Sbjct: 1877 AYCVYRREMDPEIDIMCTGPEAGNTEEKSAEEVTMSPAIAIMQPILRFLQLLCENHNREL 1936

Query: 6172 QNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFG-EIGEHNFSLITQTLATLTEFC 6348
            QNFLR Q+++TN+NLV ETL FLD +CGST G LG+ G  I E N +L+ Q L +LTE+C
Sbjct: 1937 QNFLRNQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINEKNVALVNQNLESLTEYC 1996

Query: 6349 QGPCHENQNTMAMQE-NGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIMESRH 6525
            QGPCHENQ  +A  E NG++III+L+LN+I PL    M+L L++K+ AS
Sbjct: 1997 QGPCHENQTCIATHESNGIDIIIALILNDINPLGKYRMDLVLQLKNNAS----------- 2045

Query: 6526 DGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLKKKSG 6705
                               K L+  ++  ++  N+   +     R+L      D+ K +
Sbjct: 2046 -------------------KLLLAIMESRHDSENAERILFNMRPRELV-----DVMKNAY 2081

Query: 6706 PQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNIYILAHQ 6885
             Q                G+   H         DD+  DD    V P++VGHNIYILAHQ
Sbjct: 2082 NQ----------------GLECDHG--------DDEGGDD---GVSPKDVGHNIYILAHQ 2114

Query: 6886 LAIHDGELEIWLD-GSDEKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPINDICSY 7062
            LA H+  L+  L  GSD  + D   EAL YY   TAQIEIVR DRT+E++VFP+ +IC Y
Sbjct: 2115 LARHNKLLQQMLKPGSDPDEGD---EALKYYANHTAQIEIVRHDRTMEQIVFPVPNICEY 2171

Query: 7063 LTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPLWTR 7242
            LT+++K  V+N TERD QGSKV +FF + E +Y+EM WQ+K+++   L W +  + LW
Sbjct: 2172 LTRESKCRVFNTTERDEQGSKVNDFFQQTEDLYNEMKWQKKIRNNPALFWFSRHISLWGS 2231

Query: 7243 LSFHFAFIVNALVARYYPLPEHSNSSISLGNLYS---WFAV-FSSFLLAHYLRHDKIYLH 7410
            +SF+ A  +N  VA +YP  +  +   +L  L+S   W AV   + +L  + +   I
Sbjct: 2232 ISFNLAVFINLAVALFYPFGDDGDEG-TLSPLFSVLLWIAVAICTSMLFFFSKPVGI--- 2287

Query: 7411 KTXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACR 7590
                             IG+  TL + G   L NKIV +V+FV N+G   R    ++
Sbjct: 2288 ---RPFLVSIMLRSIYTIGLGPTLILLGAANLCNKIVFLVSFVGNRGTFTRGYRAVILDM 2344

Query: 7591 NLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALI 7770
               Y + Y+ +C+LGL VH   Y  LLFD+++ EETL NVI SVTRN +SI+ T +LALI
Sbjct: 2345 AFLYHVAYVLVCMLGLFVHEFFYSFLLFDLVYREETLLNVIKSVTRNGRSIILTAVLALI 2404

Query: 7771 LLYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPS-------ETCPSEGCPGLQPSX 7929
            L+Y FSI+GFL+ + DF +EVD ++N +  T S  +P+       E C  E C    P+
Sbjct: 2405 LVYLFSIIGFLFLKDDFTMEVDRLKNRTPVTGSHQVPTMTLTTMMEACAKENCSPTIPAS 2464

Query: 7930 XXXXXXXXXXX--SCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTX 8103
                         +C+TL MCI+    QGLRNGGG+GDVLR P+  E +F  RV YD+
Sbjct: 2465 NTADEEYEDGIERTCDTLLMCIVTVLNQGLRNGGGVGDVLRRPSKDEPLFAARVVYDLLF 2524

Query: 8104 XXXXXXXXXXXXXXXXXDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRE 8283
                             DTF DLR+EK +KE+ILK  CFICGL+R +FDN++V+FE H +
Sbjct: 2525 YFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIK 2584

Query: 8284 TEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQS 8463
            +EHN+WHYLY+IV++++KD TE+TGPESYVAQ + ++NLDWFPRM+A+SL  +E D++Q+
Sbjct: 2585 SEHNMWHYLYFIVLVKVKDPTEYTGPESYVAQMIVEKNLDWFPRMRAMSLVSNEGDSEQN 2644

Query: 8464 EVKQMKDQLLQMMTLMREIISQNEESRAFMEQ 8559
            E++ ++++L   M+L++++  Q  E +  M +
Sbjct: 2645 EIRSLQEKLESTMSLVKQLSGQLAELKEQMTE 2676


>gi|27805961|ref|NP_776794.1| inositol 1,4,5-triphosphate receptor,
            type 2 [Bos taurus]
 gi|17432546|gb|AAL39077.1| inositol 1,4,5-trisphosphate receptor type
            2 [Bos taurus]
          Length = 2701

 Score = 1624 bits (4205), Expect = 0.0
 Identities = 1052/2910 (36%), Positives = 1557/2910 (53%), Gaps = 93/2910 (3%)
 Frame = +1

Query: 109  LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
            L+IGDI+SLY E S N    GF++TLGLVDDRC+V  + G   +PPKKFRDCLFKVCP+N
Sbjct: 9    LYIGDIVSLYAEGSVN----GFINTLGLVDDRCVVHPEAGDLANPPKKFRDCLFKVCPMN 64

Query: 289  RYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQ 468
            RY+AQK  W  ++  Q   +  +  L+ KL+ AA+ E+++NESE +K LG +++Y +++Q
Sbjct: 65   RYSAQKQYWKAKQAKQGNHT--EAALLKKLQHAAELEQKQNESENKKLLGEIVKYSNVIQ 122

Query: 469  LLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKI 648
            LLH+KSNKY+TV K  PA  E+NAM+V LD AGNEGSWF I P +K  + GDN+  G K+
Sbjct: 123  LLHIKSNKYLTVNKRLPALLEKNAMRVSLDAAGNEGSWFYIHPFWKLRSEGDNIVVGGKV 182

Query: 649  SLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSV 828
             L+P       AG     LH S+  LLD+    EVN +N  T W++ +F+ +   +++ +
Sbjct: 183  VLMP-----VNAGQ---PLHASNIELLDNPGCKEVNAVNCNTSWKITLFMKYSSYREDVL 234

Query: 829  KSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTN 1008
            K GDVVRLFHA+Q+ FLT D   K+      +FLR T R SA  ATSS+ALWE++VV  +
Sbjct: 235  KGGDVVRLFHAEQEKFLTCDEYEKKQH----IFLRTTLRQSATSATSSKALWEIEVVHHD 290

Query: 1009 AYRGGTAKWNKAYRFKHLATDMYLSAE------PSQVQVKPAMNGRPPLLSALSQKSRPM 1170
              RGG  +WN  +RFKHLAT  YL+AE       +Q + K   +G  P     S+K R
Sbjct: 291  PCRGGAGQWNSLFRFKHLATGNYLAAELNPDYRDAQNEGKNVRDGDLPA----SKKKRQA 346

Query: 1171 LERTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANLLFQLDPSTFM 1350
             E+    +     G                                D   LF+LD +T
Sbjct: 347  GEKIMYTLVSVPHG-------------------------------NDIASLFELDATTLQ 375

Query: 1351 KSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWVKVICEKNRVDKETFA 1530
            +++  VPR SYVRL H  ++ WV +T+         + +     +K+   + + DKE FA
Sbjct: 376  RADCLVPRNSYVRLRHLCTNTWVTSTSIPID-----TDEERPVMLKIGTCQTKEDKEAFA 430

Query: 1531 LLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDH 1710
            ++ V P EVRDLDFANDA K L   +K ++ G +   E     T+LL D I FV +  ++
Sbjct: 431  IVSVPPSEVRDLDFANDANKVLATTVKKLENGTITQNER-RFVTKLLEDLIFFVADVPNN 489

Query: 1711 LADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSR 1890
              D L +    P+R+RQKL+REQ +L QVF +LKAPF  + G               D R
Sbjct: 490  GQDVLDVLITKPNRERQKLMREQNILAQVFGILKAPFKEKAGE----GSMLRLEDLGDQR 545

Query: 1891 NEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKL 2070
               +K M +LCY +L +SQ  YRKNQE++A+ F  +Q QIG+D++AEDT+TA+LHNN KL
Sbjct: 546  YAPYKYMLRLCYRVLGHSQQDYRKNQEYIAKNFCVMQSQIGYDILAEDTITALLHNNRKL 605

Query: 2071 LEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIF 2250
            LEK++    +E FV L+R NR+ +FLDYL+DLCV    A    QELIC  +LS  + DI
Sbjct: 606  LEKHITAKEIETFVSLLRRNREPRFLDYLSDLCVSNTTAIPVTQELICKFMLSPGNADIL 665

Query: 2251 MDTKII------------------DGEIEVGWA-----PNFRKLVDIAEGAKSNSD-DAE 2358
            + TK++                  + E+ + W      P+ + +  +A+ AK  +  D E
Sbjct: 666  IQTKLVSMQGDNPMESAILSDDIDEEEVWLYWIDSNKEPHGKAIRHLAQEAKEGTKADLE 725

Query: 2359 HLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGS 2538
             L YYR+QL+L ++MC ++QYLAI+         IS QL  +L+L+CMSD  LP+DLR S
Sbjct: 726  VLTYYRYQLNLFARMCLDRQYLAIN--------QISTQLSVDLILRCMSDESLPFDLRAS 777

Query: 2539 FTRLMLHLHVVRGSPMSAI--RHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIA 2712
            F RLMLH+HV R    S +  R+ARLW  IP  + +  Y+S++     D SR  +    A
Sbjct: 778  FCRLMLHMHVDRDPQESVVPVRYARLWTEIPTKITIHEYDSIT-----DSSRNDMKRKFA 832

Query: 2713 HKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLL 2892
               +  VE YL  + NQ          +KLT+E+V+LA+ L  F FYSF++LL+LT+ LL
Sbjct: 833  -LTMEFVEEYLKEVVNQPFPFGDK-EKNKLTFEVVHLARNLIYFGFYSFSELLRLTRTLL 890

Query: 2893 AIIN--EGPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAK-----------TPSV 3033
            AI++  + P +          +   N+ +++   G       L++            PS+
Sbjct: 891  AILDIVQAPMSSYFERLSKFQDGGNNVMRTIHGVGEMMTQMVLSRGSIFPMSVPDIQPSL 950

Query: 3034 TAEEAGRTKEGRALNVK-TKLIVAEILQFVMDVRRDYRITMALSWFKNVF-------PCD 3189
               + G   +   + V  TKL + EILQF++ VR DY I+  LS +K  F
Sbjct: 951  HPSKQGSPTDHEDVTVMDTKLKIIEILQFILSVRLDYGISYMLSIYKKEFGENNGNAEMS 1010

Query: 3190 EDGS---LMHSA---SINERMASELYDAIYRSSGHELHLDGRDGQLLLAILLQMTMSDYP 3351
             +GS   L+ SA    I+E  A        R   + + LD   G+  L +L+ + M DYP
Sbjct: 1011 TNGSPDTLLPSAIVPDIDEIAAQAETMFAGRKEKNPVQLDDEGGRTFLRVLIHLIMHDYP 1070

Query: 3352 PLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWV 3531
            PL S AL++ F+HF+Q  E+L+  KQVQLLVSN DV+NY+QI  DL  L+   EKSELWV
Sbjct: 1071 PLLSGALQLLFKHFSQRAEVLQAFKQVQLLVSNQDVDNYKQIKADLDQLRLTVEKSELWV 1130

Query: 3532 HGDRHHSIDTKEVDEKE-RTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNEC 3708
              ++  S +  E+ E + +  E  + D ++ SP
Sbjct: 1131 --EKSSSYENGEMGENQVKGGEEPIEDSNILSP--------------------------- 1161

Query: 3709 LQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDPKPDTMNQQ 3888
                    ++D      +   + ++      Y +++++L+RL+ +C +  + K    +Q+
Sbjct: 1162 --------VQDGTKKPQIDSNKSNN------YRIVKEILIRLSKLCVQ--NKKCRNQHQR 1205

Query: 3889 LLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEK 4068
            LLKNM  + VVL+ + +P++K +D  M +++ L+H FL++FC+ N +NQ  L+K ++
Sbjct: 1206 LLKNMGAHSVVLDLLQIPYEK-NDEKMNEVMNLAHTFLQNFCRGNPQNQVLLHKHLNLF- 1263

Query: 4069 DAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQAL 4248
                G+L  ET+        IF NN  L + + E ++ H V  IE + R+  +L  LQ +
Sbjct: 1264 -LTPGLLEAETMRH------IFMNNYHLCNEISERVVQHFVHCIETHGRHVEYLRFLQTI 1316

Query: 4249 VCVYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKL 4428
            V    K ++  Q+ V  E+    ++V   Y D ASF  L  MM  E++      D    L
Sbjct: 1317 VKADGKYVKKCQDMVMTELINGGEDVLIFYNDRASFPILLHMMCSERDR----GDESGPL 1372

Query: 4429 KYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYI 4608
             YHI LV LLA CT GKN  TE+KC S +P+D IVRVVT   C+ EVK  Y+  + HCY+
Sbjct: 1373 AYHITLVELLAACTEGKNVYTEIKCNSLLPLDDIVRVVTHDDCIPEVKIAYVNFVNHCYV 1432

Query: 4609 DTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEKLTGAETAT-LEHYICHTVTEVLIKFFE 4785
            DT+ EMK+ Y + ++  +  N L D+  +           T LE  +  ++  ++  FF
Sbjct: 1433 DTEVEMKEIYTSNHIWKLFENFLVDMARVCNTTTDRKHADTFLEKCVTESIMNIVSGFFN 1492

Query: 4786 APYSALQQAKVDVHHHKKTFSEVLLELTYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEE 4965
            +P+S        +  H+  F ++L     +            +   V  CI+ L + A+
Sbjct: 1493 SPFS---DNSTSLQTHQPVFIQLLQSAFRIYNCTWPNPAQKAS---VESCIRTLAEVAKN 1546

Query: 4966 HNITLPATLAGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSMT 5145
              I +P  L     +          Q A+      +G RL+ ++       L G S
Sbjct: 1547 RGIAIPVDLDSQVNTLFLKSHSNMVQRAA------MGWRLSARSGPRFKEALGGPSWDYR 1600

Query: 5146 EHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVV 5325
                 N++     ++   +    P+  AE SVLV+VL++PELLFPEGS  R +C  G  +
Sbjct: 1601 -----NIIEKLQDVVASLEQQFSPMMQAEFSVLVDVLYSPELLFPEGSDARIRC--GAFM 1653

Query: 5326 AKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKQQLTHQGHRVYNSSVEKGXXXXXXXX 5505
            +KLI H K LM+ K++ LC ++LQTL +M +              +S VE+G
Sbjct: 1654 SKLINHTKKLME-KEEKLCIKILQTLREMLEKK------------DSFVEEGNTLRKILL 1700

Query: 5506 XXYFGHHNNHHPPLDRQQSXXXXXXXXXXXXXXXTWSQERDLYA--IQCKLNDAGASDLV 5679
              YF    ++   ++   S                 S +  +    IQC L+  GAS+LV
Sbjct: 1701 NRYF--KGDYGVSINGHLSGTYCKTAQVGGSFSGQDSDKMGISMSDIQCLLDKEGASELV 1758

Query: 5680 TDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQ 5859
             D+I+   +  IF + I L  ALL  GN + Q+SFY ++ ++   E FFK +  R++ AQ
Sbjct: 1759 IDVIVNTKNDRIFSEGILLGIALLEGGNTQTQYSFYQQLHEQKKSEKFFKVLYDRMKAAQ 1818

Query: 5860 NRLKSDM----MSCSDSKPKVSSTVLT--PLIDAGDT------GFNGALFEVPQQVRHPS 6003
              ++S +    +   + K    + ++T  P +   D+      G  G L E
Sbjct: 1819 KEIRSTVTVNTIDLGNKKRDDDTELMTSGPRMRVRDSSLHLKEGMKGQLTEASSATSKAY 1878

Query: 6004 ISEMSQLSN--DLTHSIPDLAPYQDEEKSTDALPPEVALVEPILRVLQLLCENHNSLLQN 6177
                 ++    D+  + P+    +D       + P +A+++PI R LQLLCENHN  LQ+
Sbjct: 1879 CVYRREMDPEIDIMCAGPEAGNAEDRSTEEVTMSPAIAIMQPISRFLQLLCENHNRELQH 1938

Query: 6178 FLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFG-EIGEHNFSLITQTLATLTEFCQG 6354
            FLR Q+++TN+NLV ETL FLD +CGST G LG+ G  I E N  L+ QTL +LTE+CQG
Sbjct: 1939 FLRNQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINEKNVVLVNQTLESLTEYCQG 1998

Query: 6355 PCHENQNTMAMQE-NGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIMESRHDG 6531
            PCHENQ  +A  E NG++III+L+LN+I PL    M+L L++K+ A
Sbjct: 1999 PCHENQTCIATHESNGIDIIIALILNDINPLGKYRMDLVLQLKNNA-------------- 2044

Query: 6532 ENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLKKKSGPQ 6711
                            PK L+  ++  ++  N+   +     R+L      D+ K +  Q
Sbjct: 2045 ----------------PKLLLAIMESRHDSENAERILFNMRPRELV-----DVMKNAYNQ 2083

Query: 6712 ITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNIYILAHQLA 6891
                            G+   H         DD+  DDD   V P++VGHNIYILAHQLA
Sbjct: 2084 ----------------GLECDHG--------DDEGGDDD---VSPKDVGHNIYILAHQLA 2116

Query: 6892 IHDGELEIWLD-GSDEKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPINDICSYLT 7068
             H+  L+  L  GSD    D   EAL YY   TAQIEIVR DRT+E++VFP+ +IC YLT
Sbjct: 2117 RHNKLLQQMLKPGSDPDDGD---EALKYYANHTAQIEIVRHDRTMEQIVFPVPNICEYLT 2173

Query: 7069 KDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPLWTRLS 7248
            +++K  V+N TERD QGSKV +FF + E +Y+EM WQ+K++    L W +  + LW  +S
Sbjct: 2174 RESKCRVFNTTERDEQGSKVNDFFQQTEDLYNEMKWQKKIRSNPALFWFSRHISLWGSIS 2233

Query: 7249 FHFAFIVNALVARYYPLPEHSNSSISLGNLYS---WFAV-FSSFLLAHYLRHDKIYLHKT 7416
            F+ A  +N  VA +YP  +  +   +L  ++S   W AV   + +L  + +   I
Sbjct: 2234 FNLAVFINLAVALFYPFGDDGDEG-TLSPMFSILLWIAVAICTSMLFFFSKPVGI----- 2287

Query: 7417 XXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRNL 7596
                           IG+  TL + G   L NKIV +V+FV N+G   R    ++
Sbjct: 2288 -RPFLVSVMLRSIYTIGLGPTLILLGAANLCNKIVFLVSFVGNRGTFTRGYRAVILDMAF 2346

Query: 7597 HYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALILL 7776
             Y + Y+ +C+LGL VH   Y  LLFD+++ EETL NVI SVTRN +SI+ T +LALIL+
Sbjct: 2347 LYHVAYVLVCMLGLFVHEFFYSFLLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILV 2406

Query: 7777 YFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPS-------ETCPSEGCPGLQPSXXX 7935
            Y FSI+GFL+ + DF +EVD ++N +  T S+ +P+        TC  + C    P+
Sbjct: 2407 YLFSIIGFLFLKDDFTMEVDRLKNRTPITGSNAVPTMTLTSILSTCEKDNCSPTIPASNT 2466

Query: 7936 XXXXXXXXX--SCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTXXX 8109
                       +C+TL MCI+    QGLRNGGG+GDVLR P+  E +F  RV YD+
Sbjct: 2467 ADEEYEDGIERTCDTLLMCIVTVLNQGLRNGGGVGDVLRRPSKDEPLFAARVVYDLLFYF 2526

Query: 8110 XXXXXXXXXXXXXXXDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETE 8289
                           DTF DLR+EK +KE+ILK  CFICGL+R +FDN++V+FE H ++E
Sbjct: 2527 IVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKSE 2586

Query: 8290 HNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEV 8469
            HN+WHYLY++V++++KD TE+TGPESYVAQ + ++NLDWFPRM+A+SL  SE D++Q+EV
Sbjct: 2587 HNMWHYLYFLVLVKVKDPTEYTGPESYVAQMIVEKNLDWFPRMRAMSLVSSEGDSEQNEV 2646

Query: 8470 KQMKDQLLQMMTLMREIISQNEESRAFMEQ 8559
            + ++++L   M+L++++ SQ  E +  M +
Sbjct: 2647 RNLQEKLESTMSLVKQLSSQLAELKEQMTE 2676


>gi|13022060|gb|AAK11622.1| IP3 receptor isoform 2 [Rattus norvegicus]
 gi|34851154|gb|AAQ82910.1| inositol trisphosphate receptor type 2
            [Rattus norvegicus]
          Length = 2701

 Score = 1621 bits (4198), Expect = 0.0
 Identities = 1063/2916 (36%), Positives = 1563/2916 (53%), Gaps = 99/2916 (3%)
 Frame = +1

Query: 109  LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
            L+IGDI+SLY E S N    GF+STLGLVDDRC+V  + G   +PPKKFRDCLFKVCP+N
Sbjct: 9    LYIGDIVSLYAEGSVN----GFISTLGLVDDRCVVHPEAGDLTNPPKKFRDCLFKVCPMN 64

Query: 289  RYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQ 468
            RY+AQK  W  ++  Q   +  +  L+ KL+ AA+ E+++NESE +K LG +++Y +++Q
Sbjct: 65   RYSAQKQYWKAKQAKQGNHT--EAALLKKLQHAAELEQKQNESENRKLLGEIVKYSNVIQ 122

Query: 469  LLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKI 648
            LLH+KSNKY+TV K  PA  E+NAM+V LD AGNEGSWF I P +K  + GDN+  G+K+
Sbjct: 123  LLHIKSNKYLTVNKRLPALLEKNAMRVSLDAAGNEGSWFYIHPFWKLRSEGDNIVVGDKV 182

Query: 649  SLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSV 828
             L+P       AG     LH S+  LLD+    EVN +N  T W++ +F+ F   +++ +
Sbjct: 183  VLMP-----VNAGQ---PLHASNVELLDNPGCKEVNAVNCNTSWKITLFMKFSSYREDVL 234

Query: 829  KSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTN 1008
            K GDVVRLFHA+Q+ FLT D   K+      +FLR T R SA  ATSS+ALWE++VV  +
Sbjct: 235  KGGDVVRLFHAEQEKFLTCDDYEKKQH----IFLRTTLRQSATSATSSKALWEIEVVHHD 290

Query: 1009 AYRGGTAKWNKAYRFKHLATDMYLSAE------PSQVQVKPAMNGRPPLLSALSQKSRPM 1170
              RGG  +WN  +RFKHLAT  YL+AE       +Q + K   +G  P     S+K R
Sbjct: 291  PCRGGAGQWNSLFRFKHLATGNYLAAELNPDYRDAQNEGKTVRDGELPT----SKKKRQA 346

Query: 1171 LERTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANLLFQLDPSTFM 1350
             E+    +     G                                D   LF+LD +T
Sbjct: 347  GEKIMYTLVSVPHG-------------------------------NDIASLFELDATTLQ 375

Query: 1351 KSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKG-WVKVICEKNRVDKETF 1527
            +++  VPR SYVRL H  ++ WV +T+      +   ++ E+   +K+   + + DKE F
Sbjct: 376  RADCLVPRNSYVRLRHLCTNTWVTSTS------IPIDTEEERPVMLKIGTCQTKEDKEAF 429

Query: 1528 ALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSD 1707
            A++ V   EVRDLDFANDA K L   +K ++ G +   E     T+LL D I FV + ++
Sbjct: 430  AIVCVPLSEVRDLDFANDANKVLATTVKKLENGSITQNER-RFVTKLLEDLIFFVADVTN 488

Query: 1708 HLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDS 1887
            +  D L +    P+R+RQKL+REQ +L QVF +LKAPF  + G               D
Sbjct: 489  NGQDVLDVVITKPNRERQKLMREQNILAQVFGILKAPFKEKAGE----GSMLRLEDLGDQ 544

Query: 1888 RNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPK 2067
            R   +K + +LCY +L++SQ  YRKNQE++A+ F  +Q QIG+D++AEDT+TA+LHNN K
Sbjct: 545  RYAPYKYVLRLCYRVLRHSQQDYRKNQEYIAKNFCVMQSQIGYDILAEDTITALLHNNRK 604

Query: 2068 LLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDI 2247
            LLEK++    +E FV L+R NR+ +FLDYL+DLCV    A    QELIC  +LS  + DI
Sbjct: 605  LLEKHITAKEIETFVSLLRRNREPRFLDYLSDLCVSNSTAIPVTQELICKFMLSPGNADI 664

Query: 2248 FMDTKII------------------DGEIEVGWA-----PNFRKLVDIAEGAKSNSD-DA 2355
             + TK++                  D E+ + W      P+ + +  +A+ A+  +  D
Sbjct: 665  LIQTKLVSMQVENPMESSILPDDIDDEEVWLYWIDSNKEPHGKAIRHLAQEAREGTKADL 724

Query: 2356 EHLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRG 2535
            E L YYR+QL+L ++MC ++QYLAI+         IS QL  +L+L+C+SD  LP+DLR
Sbjct: 725  EVLTYYRYQLNLFARMCLDRQYLAIN--------QISTQLSVDLILRCVSDESLPFDLRA 776

Query: 2536 SFTRLMLHLHVVRGSPMSAI--RHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGI 2709
            SF RLMLH+HV R    S +  R+ARLW  IP  + +  Y+S++     D SR  +
Sbjct: 777  SFCRLMLHMHVDRDPQESVVPVRYARLWTEIPTKITIHEYDSIT-----DSSRNDMKRKF 831

Query: 2710 AHKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNL 2889
            A   +  VE YL  + NQ          +KLT+E+V+LA+ L  F FYSF++LL+LT+ L
Sbjct: 832  A-LTMEFVEEYLKEVVNQPFPFGDK-EKNKLTFEVVHLARNLIYFGFYSFSELLRLTRTL 889

Query: 2890 LAIIN--EGPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAK-----------TPS 3030
            LAI++  + P +          +   N+ +++   G       L++            PS
Sbjct: 890  LAILDIVQAPMSSYFERLSKFQDGSNNVMRTIHGVGEMMTQMVLSRGSIFPVSVPDAQPS 949

Query: 3031 VTAEEAGRTKEGRALNVK-TKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLM 3207
            V   +     E   + V  TKL V EILQF++ VR DYRI+  LS +K  F  + DG+
Sbjct: 950  VHPSKQASPGEQEDVTVMDTKLKVIEILQFILSVRLDYRISYMLSIYKKEFG-ENDGNGD 1008

Query: 3208 HSAS--------------INERMASELYDAIYRSSGHELHLDGRDGQLLLAILLQMTMSD 3345
             SAS              I+E  A        R     + LD   G+  L +L+ + M D
Sbjct: 1009 PSASGTPETLLPSALVPDIDEIAAQAETMFAGRKEKTPVQLDDEGGRTFLRVLIHLIMHD 1068

Query: 3346 YPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSEL 3525
            Y PL S AL++ F+HF+Q  E+L+  KQVQLLVSN DV+NY+QI  DL  L+   EKSEL
Sbjct: 1069 YAPLLSGALQLLFKHFSQRAEVLQAFKQVQLLVSNQDVDNYKQIKADLDQLRLTVEKSEL 1128

Query: 3526 WVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNE 3705
            WV                             +   ++++GD  E       E      NE
Sbjct: 1129 WV-----------------------------EKSGSYENGDMGEGQAKGGEE-----ANE 1154

Query: 3706 CLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDPKPDTMNQ 3885
               LL+ +       D A   Q  S+K     Y +++++L+RL+ +C +  + K    +Q
Sbjct: 1155 ESNLLSPV------QDGAKTPQIDSNKGN--NYRIVKEILIRLSKLCVQ--NKKCRNQHQ 1204

Query: 3886 QLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYE 4065
            +LLKNM  + VVL+ + +P++K  D  M +++ L+H FL++FC+ N +NQ  L+K ++
Sbjct: 1205 RLLKNMGAHSVVLDLLQIPYEKT-DEKMNEVMDLAHTFLQNFCRGNPQNQVLLHKHLNLF 1263

Query: 4066 KDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQA 4245
                 G+L  ET+        IF NN  L + + E ++ H V  IE + R+  +L  LQ
Sbjct: 1264 --LTPGLLEAETMRH------IFMNNYHLCNEISERVVQHFVHCIETHGRHVEYLRFLQT 1315

Query: 4246 LVCVYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRK 4425
            +V    K ++  Q+ V  E+    ++V   Y D ASF  L  MM  E+       D
Sbjct: 1316 IVKADGKYVKKCQDMVMTELINGGEDVLIFYNDRASFPILLNMMCSERAR----GDESGP 1371

Query: 4426 LKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCY 4605
            L YHI LV LLA CT GKN  TE+KC S +P+D IVRVVT   C+ EVK  Y+  + HCY
Sbjct: 1372 LAYHITLVELLAACTEGKNVYTEIKCNSLLPLDDIVRVVTHDDCIPEVKIAYVNFVNHCY 1431

Query: 4606 IDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEKLTGAETAT-LEHYICHTVTEVLIKFF 4782
            +DT+ EMK+ Y + ++  +  N L D+  +           T LE  +  +V  ++  FF
Sbjct: 1432 VDTEVEMKEIYTSNHIWKLFENFLVDMARVCNTTTDRKHADTFLERCVTESVMNIVSGFF 1491

Query: 4783 EAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGKLRGSKSSRNWYRVAECIKRLTKWAE 4962
             +P+S        +  H+  F ++L     +            +   V  CI+ L + A+
Sbjct: 1492 NSPFS---DNSTSLQTHQPVFIQLLQSAFRIYNCTWPNPAQKAS---VESCIRALAEVAK 1545

Query: 4963 EHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSM 5142
               I +P  L     S   ++  K    +S+ +   +G RL+ ++       L G +
Sbjct: 1546 NRGIAIPVDLD----SQVNTLFMK--NHSSTVQRAAMGWRLSARSGPRFKEALGGPAWDY 1599

Query: 5143 TEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCARGGV 5322
                  N++     ++   +    P+  AE SVLV+VL++PELLFPEGS  R +C  G
Sbjct: 1600 R-----NIIEKLQDVVASLEQQFSPMMQAEFSVLVDVLYSPELLFPEGSDARIRC--GAF 1652

Query: 5323 VAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKQQLTHQGHRVYNSSVEKGXXXXXXX 5502
            ++KLI H K LM+ K++ LC ++LQTL +M +              +S +E+G
Sbjct: 1653 MSKLINHTKKLME-KEEKLCIKILQTLREMLEKK------------DSFMEEGSTLRKIL 1699

Query: 5503 XXXYF--GHHNNHHPPLDRQQSXXXXXXXXXXXXXXXTWSQERD-----LYAIQCKLNDA 5661
               YF   H    + PL    +                  Q+ D     +  IQC L+
Sbjct: 1700 LNRYFKGDHSVGVNGPLSGAYAKTAQVGGGFT-------GQDADKTGISMSDIQCLLDKE 1752

Query: 5662 GASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEPFFKAILT 5841
            GAS+LV D+I+   +  IF + I L  ALL  GN + Q+SFY ++ ++   E FFK +
Sbjct: 1753 GASELVIDVIVNTKNDRIFSEGILLGIALLEGGNTQTQNSFYQQLHEQKKSEKFFKVLYD 1812

Query: 5842 RIQTAQNRLKSDM----MSCSDSKPKVSSTVLT--PLIDAGDT------GFNGALFEVPQ 5985
            R++ AQ  ++S +    +     K +  S ++   P +   D+      G  G L E
Sbjct: 1813 RMKAAQKEIRSTVTVNTIDLGSKKREEDSDLMALGPRMRVRDSSLHLKEGMKGQLTEASS 1872

Query: 5986 QVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTD--ALPPEVALVEPILRVLQLLCENH 6159
                       ++  D+    P       EEKS +   + P + ++ PILR LQLLCENH
Sbjct: 1873 ATSKAYCVYRREMDPDIDTMCPGQEAGSAEEKSAEEVTMSPAITIMRPILRFLQLLCENH 1932

Query: 6160 NSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFG-EIGEHNFSLITQTLATL 6336
            N  LQNFLR Q+++TN+NLV ETL FLD +CGST G LG+ G  I E N +L+ QTL +L
Sbjct: 1933 NRELQNFLRNQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINEKNVALVNQTLESL 1992

Query: 6337 TEFCQGPCHENQNTMAMQE-NGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIM 6513
            TE+CQGPCHENQ  +A  E NG++III+L+L++I PL    M+L L+
Sbjct: 1993 TEYCQGPCHENQTCIATHESNGIDIIIALILSDINPLGKYRMDLVLQ------------- 2039

Query: 6514 ESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLK 6693
                        L+N A+     K L+  ++  ++  N+   +     ++L      D+
Sbjct: 2040 ------------LKNNAS-----KLLLAIMESRHDSENAERILFNMRPKELV-----DVM 2077

Query: 6694 KKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNIYI 6873
            K +  Q                G+   H         D++  DD    V P++VGHNIYI
Sbjct: 2078 KNAYNQ----------------GLECNHG--------DEEGGDD---GVSPKDVGHNIYI 2110

Query: 6874 LAHQLAIHDGELEIWLD-GSDEKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPIND 7050
            LAHQLA H+  L+  L  GSD ++ D   EAL YY   TAQIEIVR DRT+E++VFP+ +
Sbjct: 2111 LAHQLARHNKLLQQMLKPGSDPEEGD---EALKYYANHTAQIEIVRHDRTMEQIVFPVPN 2167

Query: 7051 ICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLP 7230
            IC +LT+++K  V+N TERD QGSKV +FF + E +Y+EM WQ+K+++   L W +  +
Sbjct: 2168 ICEFLTRESKYRVFNTTERDEQGSKVNDFFQQTEDLYNEMKWQKKIRNNPALFWFSRHIS 2227

Query: 7231 LWTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYS---WFAV-FSSFLLAHYLRHDK 7398
            LW  +SF+ A  +N  VA +YP  +  +   +L  L+S   W AV   + +L  + +
Sbjct: 2228 LWGSISFNLAVFINLAVALFYPFGDDGDEG-TLSPLFSALLWVAVAICTSMLFFFSKPVG 2286

Query: 7399 IYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEI 7578
            I                    IG+  TL + G   L NKIV +V+FV N+G   R    +
Sbjct: 2287 I------RPFLVSIMLRSIYTIGLGPTLILLGAANLCNKIVFLVSFVGNRGTFTRGYRAV 2340

Query: 7579 LACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGL 7758
            +      Y + Y+ +C+LGL VH   Y  LLFD+++ EETL NVI SVTRN +SI+ T +
Sbjct: 2341 ILDMAFLYHVAYVLVCMLGLFVHEFFYSFLLFDLVYREETLLNVIKSVTRNGRSIILTAV 2400

Query: 7759 LALILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSET-------CPSEGCPGL 7917
            LALIL+Y FSI+GFL+ + DF +EVD ++N +  T + G+P+ T       CP E C
Sbjct: 2401 LALILVYLFSIIGFLFLKDDFTMEVDRLKNRTPVTGNDGVPTMTLTSMLGTCPKENCSPT 2460

Query: 7918 QPSXXXXXXXXXXXX--SCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAY 8091
             PS              +C+TL MCI+    QGLRNGGG+GDVLR P+  E +F  RV Y
Sbjct: 2461 IPSSNAAGEGGEDGIERTCDTLLMCIVTVLNQGLRNGGGVGDVLRRPSKDEPLFAARVVY 2520

Query: 8092 DMTXXXXXXXXXXXXXXXXXXDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFE 8271
            D+                   DTF DLR+EK +KE+ILK  CFICGL+R +FDN++V+FE
Sbjct: 2521 DLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFE 2580

Query: 8272 THRETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELD 8451
             H ++EHN+WHYLY+IV++++KD TE+TGPESYVAQ + ++NLDWFPRM+A+SL  +E D
Sbjct: 2581 EHIKSEHNMWHYLYFIVLVKVKDPTEYTGPESYVAQMITEKNLDWFPRMRAMSLVSNEGD 2640

Query: 8452 TDQSEVKQMKDQLLQMMTLMREIISQNEESRAFMEQ 8559
            ++Q+E++ ++++L   M+L++++  Q  E +  M +
Sbjct: 2641 SEQNEIRNLQEKLESTMSLVKQLSGQLAELKEQMTE 2676


>gi|18307586|dbj|BAB84088.1| inositol 1,4,5-trisphosphate receptor
            [Asterina pectinifera]
          Length = 2698

 Score = 1617 bits (4187), Expect = 0.0
 Identities = 1061/2920 (36%), Positives = 1532/2920 (52%), Gaps = 103/2920 (3%)
 Frame = +1

Query: 109  LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
            LH GDI+SLY E S N    GF+STLGLVDDRC+V+   G   +PPKKFRDCLFK+CP+N
Sbjct: 9    LHFGDIVSLYAEGSVN----GFISTLGLVDDRCVVQPDFGDLNNPPKKFRDCLFKICPMN 64

Query: 289  RYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQ 468
            RY AQK  W   K      S  D  L+ KL+ AA+ E+++NE+E +K +G+VI YG+++Q
Sbjct: 65   RYTAQKQFWKSAK--PNVSSATDAVLLKKLQHAAEMEKKQNETENKKLMGSVIVYGNVIQ 122

Query: 469  LLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKI 648
            LLH+KS+KY+TV K  PA  E+NAM+V LD +  EGSWF I P YK  + GDNV  G+K+
Sbjct: 123  LLHIKSHKYMTVNKRLPALLEKNAMRVTLDSSATEGSWFYIVPFYKLRSAGDNVVVGDKV 182

Query: 649  SLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSV 828
             L P       AG     LH S++ L+D+    EVN +N  T W+V +F+   EN  + +
Sbjct: 183  VLNP-----VNAGQ---PLHPSNYELIDNPGCKEVNSVNCNTCWKVSLFMEHKENL-DGL 233

Query: 829  KSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTN 1008
            K GDVVRLFHA+Q+ FLT D   K++     +FLR T R SA  ATSS+ALWE +VVQ +
Sbjct: 234  KGGDVVRLFHAEQEKFLTCDEYKKKS----YIFLRTTGRVSATAATSSKALWETEVVQHD 289

Query: 1009 AYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRPPLLSALSQKSRPMLERTNN 1188
              RGG   WN  +RFKHLAT  Y++AE      K                     + T
Sbjct: 290  PCRGGAGHWNSLFRFKHLATGQYMAAEVDNDNTK---------------------DHTRE 328

Query: 1189 PMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEV 1368
             +     GP+G       T  Q +P +             D   +F+LDP+T    +  V
Sbjct: 329  KLR----GPHG------GTVYQMVPIIH----------GNDIASIFELDPTTLQGGDSMV 368

Query: 1369 PRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWVKVICEKNRVDKETFALLPVNP 1548
            PR SYVRL H  ++ WVH+T+    +      +++   +KV   + R D+E FA++PV+P
Sbjct: 369  PRSSYVRLRHLCTNTWVHSTSIPLDKG-----EDKPVMLKVGTAQIREDREAFAIIPVSP 423

Query: 1549 DEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADPLK 1728
             EVRDLDFANDA K L      ++   +   E     TQLL D + FV+   ++  D L
Sbjct: 424  TEVRDLDFANDANKVLSAIASKLEKSSITQNERF--VTQLLTDLVYFVSILPNNGGDALN 481

Query: 1729 ISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIFKT 1908
            +   +P RDRQKL+REQ++L Q+F +LKAPF     T              D R+  ++
Sbjct: 482  VVVQNPDRDRQKLMREQDILKQIFKILKAPF-----TDNGDGAMLKMEELADPRHAPYRH 536

Query: 1909 MFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVK 2088
            + +LCY +L+ SQ +YRKNQE++A++FG +Q+QIG+D++AEDT+TA+LHNN KLLEK++
Sbjct: 537  ICRLCYRILRLSQQAYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKHIT 596

Query: 2089 TPHVERFVELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKII 2268
               +E FV LVR N + +FL+YL+DLCV   +A    QELIC SVL  ++ DI ++TK++
Sbjct: 597  ATEIETFVNLVRKNGECRFLEYLSDLCVSNNQAIPVTQELICKSVLVERNSDILIETKLV 656

Query: 2269 DGEIEVG-------------------------WAPNFR-KLVDIAEGAKSN-SDDAEHLD 2367
              ++EV                          W    + K +    G   N  +DA  L
Sbjct: 657  RTQMEVEMEVEADDGTTEPVYTIEEEEEVVLFWKNGTKSKSIRSCHGGTENVKEDANVLK 716

Query: 2368 YYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTR 2547
            YYR+QLDL SQMC ++QYLAI+         I  QL  +L+ +CMSD  LPYDLR SFTR
Sbjct: 717  YYRYQLDLFSQMCLDRQYLAIN--------QIGPQLDIDLIHRCMSDESLPYDLRASFTR 768

Query: 2548 LMLHLHVVRG--SPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKV 2721
            LMLH+HV R     ++ +++A LW  IP  + +  Y+  +   ++     +    +  K
Sbjct: 769  LMLHMHVDRDPKEQVTPVKYAELWSEIPTQITIDDYDGANNLTHAGKEDAQPKFSLTIKF 828

Query: 2722 LATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAII 2901
               VE YL  + +  +        +KLT+E+VNLAK L  F FYSF++LL+LT+ LL+I+
Sbjct: 829  ---VEEYLCNVVSGVLVVYDK-EQNKLTFEVVNLAKHLIYFGFYSFSELLRLTKTLLSIL 884

Query: 2902 N----EGPATEQVPSHRAM--------VNAIRNMSKSMMRGGNKEN--SKDLAKTPSVTA 3039
            +     G A  ++     +        ++ +  +  +M+ G       ++D A
Sbjct: 885  DCTALHGTAPGKLDPKADIGKGGVFRSIHGVGAVMTNMVLGKRLPTPVTRDPAWPLGWGL 944

Query: 3040 EEAGRTKEGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSAS 3219
            +   +  E   L ++TKL + +ILQF+++VR DYRI+  LS FK  F   +D +   + S
Sbjct: 945  DNHNKQDE---LVMETKLKIIQILQFILNVRLDYRISCLLSIFKRDFDESKDSTDEITTS 1001

Query: 3220 INERMAS------ELYDAIYRSSGHELHLDGRD---GQLLLAILLQMTMSDYPPLTSIAL 3372
                 AS      E  + I+  S     LD  D   G+  L +L+ +TM DY PL S AL
Sbjct: 1002 GKVWTASDFEHIEEQAEGIFGGSEENTPLDLDDDDGGRTFLRVLIHLTMHDYAPLVSGAL 1061

Query: 3373 KVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHS 3552
            ++ F+HF+Q QE+LE  KQ+QLLVS+ DV+NY+QI +DL  L+ L EKSELWV+  +
Sbjct: 1062 QLLFKHFSQRQEVLEAFKQLQLLVSSQDVDNYKQIKQDLDQLR-LVEKSELWVYKGQGPD 1120

Query: 3553 IDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLL 3732
               + +D      EH   +     P   +S  S
Sbjct: 1121 ---EPMDGASGEQEHKKTEEGTSKPLKHESTSSYN------------------------- 1152

Query: 3733 IKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDP--KPDTMNQQLLKNMR 3906
                                   Y +++++L+RL+ +   +G+   K     Q+LL+NM
Sbjct: 1153 -----------------------YRVVKEILLRLSKLVCVEGNGTRKNRKHEQRLLRNMG 1189

Query: 3907 VYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGM 4086
             + VVLE + +P++K HD  M +L+ L+HEFL++FC  N  NQ  L+K I         +
Sbjct: 1190 AFTVVLELLQIPYEKNHDTRMNELMRLAHEFLQNFCWANPSNQVLLHKHID--------L 1241

Query: 4087 LRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDK 4266
                 + E  T+  IF NN +L S V E+++ H V  I  + R+  +L+ LQA+V    +
Sbjct: 1242 FLTPGLLEAQTMCHIFMNNFQLCSEVTEQVVQHFVHCIATHGRHVQYLKFLQAIVKADGQ 1301

Query: 4267 EIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIEL 4446
             I   Q+ V  E+  A ++V   Y D ASF+    MM+ E+E    SS S+ +   H
Sbjct: 1302 YIRKTQDMVMAELVNAGEDVLLFYNDKASFQMFINMMRTERERMDASSPSQYR---HQPW 1358

Query: 4447 VRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEM 4626
              L   CT GKN  TE+KC S +P+D IVRV T + CL EVK  Y+  L HCY+DT+ EM
Sbjct: 1359 TLLGLACTEGKNVYTEIKCHSLLPLDDIVRVATHEDCLPEVKNAYINFLNHCYVDTEVEM 1418

Query: 4627 KDAYKTEYVDHILNNLLEDIRSL-RVEKLTGAETATLEHYICHTVTEVLIKFFEAPYSAL 4803
            K+ Y + +V ++  N L D+  +             LE  +  TV  ++  FF +P++
Sbjct: 1419 KEIYTSNHVWNLFENFLVDMAMVCNATHDRKHHDHMLEKTVTETVMNIITMFFSSPFA-- 1476

Query: 4804 QQAKVDVHHHKKTFSEVLLELTYLEKGKLRGSK----SSRNWYRVAECIKRLTKWAEEHN 4971
                  V   +  F  +L       +G  R S+    +    Y V  CIK LT  A+
Sbjct: 1477 -DQSTTVQTRQPVFVRLL-------QGAFRVSQCDWLTGHQKYHVENCIKTLTDIAKNRG 1528

Query: 4972 ITLPATLAGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEH 5151
            I +P  L     S   ++  K      +  W+ I    +R + +
Sbjct: 1529 IAIPVDLD----SQVNTLFSKSIVMKHTRHWLAINPNRSRDSMV------------AISR 1572

Query: 5152 TSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAK 5331
               +++     ++   +  L PL  AE SVLV+VLH PELLFP     R +C  G  ++K
Sbjct: 1573 DYRSIIEGLQDIVSLLEDQLRPLVQAELSVLVDVLHRPELLFPFRHRARQKCESGAFISK 1632

Query: 5332 LIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKQQLTHQGHRVYNSSVEKGXXXXXXXXXX 5511
            LI+H + L++ K++ LC +VLQTL       K+ +T     V     EKG
Sbjct: 1633 LIKHTEKLLEEKEEKLCIKVLQTL-------KEMMT-----VDIDYSEKGEDLRQCLLLR 1680

Query: 5512 YFGHHNNHHPPLDRQQSXXXXXXXXXXXXXXXTWSQ-ERDLYAIQCKLNDAGASDLVTDI 5688
            Y+G  +          S                 S+ E  L  +QC+L+  GAS LV D+
Sbjct: 1681 YYGKSHLRMKHRGVVASGRGQTNVTSCGPGSRVLSRAEMTLAEVQCQLDKEGASSLVIDL 1740

Query: 5689 IIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRL 5868
            +I   S  +FL+++ L  ALL  GN  +Q S    +      E FFK    R++ A
Sbjct: 1741 VIKNSSNRVFLESVELGIALLEGGNTNIQKSIINCLMSDKNSEKFFKVFFDRMREASEIK 1800

Query: 5869 KSDMMSCSDSKPKVSSTV----------LTPLIDAGDT---------GFNGALFEVPQQV 5991
             +  ++  +   +   T           LT   + G T           +  L +
Sbjct: 1801 ATVTVNTGEGIGQTKPTEGRNGQHLRRRLTWPHEKGWTRPQRLNQRRAEDQLLADAALHT 1860

Query: 5992 RHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPEVALVEPILRVLQLLCENHNSLL 6171
               S       +  L  S   LA   ++ K  + +  E+A+++PILR LQLLCENHN  L
Sbjct: 1861 SKASRQSARVATTTLLASCQVLAGGAEKAKEEEKMSMEIAIMQPILRFLQLLCENHNREL 1920

Query: 6172 QNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFG-EIGEHNFSLITQTLATLTEFC 6348
            Q++LR Q+++TN+NLV ETL FLD +CGST G LG+ G  I E+N +LI QTL +LTE+C
Sbjct: 1921 QSYLRHQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINENNVALINQTLESLTEYC 1980

Query: 6349 QGPCHENQNTMAMQE-NGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIMESRH 6525
            QG CHENQN +A  E NGL+II +L+LN+I PL  + M+L LE+K+ ASKLLLAIMESRH
Sbjct: 1981 QGACHENQNAIANHESNGLDIITALILNDINPLGKNRMDLVLELKNNASKLLLAIMESRH 2040

Query: 6526 DGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLKKKSG 6705
            D ENA R+L NM+     PKQLV  IKQAY+              DL R  +D+L
Sbjct: 2041 DSENAERILLNMS-----PKQLVDVIKQAYQQ------------EDLERDDDDEL----- 2078

Query: 6706 PQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNIYILAHQ 6885
                                                  ++D  ++ PREVGHNIYILAHQ
Sbjct: 2079 ------------------------------------IIEEDDEAISPREVGHNIYILAHQ 2102

Query: 6886 LAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPINDICSYL 7065
            LA H+ EL   L  +    +  T  AL YY + TAQIEIVR+DRT+E++VFP+  +C YL
Sbjct: 2103 LAHHNKELAALLKPTGPNSE-YTDRALEYYFKHTAQIEIVRQDRTMEQIVFPVPQLCEYL 2161

Query: 7066 TKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPLWTRL 7245
            T +TK  V+   ERD+QGSKV +FF++ E M+ EM WQ+KL+ +  L   +  +  W+ +
Sbjct: 2162 TAETKIKVFTKAERDDQGSKVADFFEKTEDMFMEMKWQKKLRAQPILFLASSNMSKWSLV 2221

Query: 7246 SFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFAVFSSFLLAHYLRHDKIYLHKTXXX 7425
             F+ A IVN LVA +YP    +       ++  W    S   +    R   I
Sbjct: 2222 CFNLAVIVNLLVAFFYPFDVTTTELDHGLSMLVWLMAASLAAIVTLRRPSGI-----RPL 2276

Query: 7426 XXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRNLHYL 7605
                        IGV  TL    +L + NK + +++F+ N GL  + +  I     + Y
Sbjct: 2277 VFATILRMLIFSIGVEPTLLFLAVLTIFNKCIFILSFLGNCGLLYKGVRGIFTDMEVLYH 2336

Query: 7606 LVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALILLYFF 7785
            ++YL IC LGL VH   Y +LL D+++ E+TL NVI SVTRN++SI +T LLALIL+Y F
Sbjct: 2337 ILYLIICFLGLFVHEFFYSLLLLDVVYQEDTLINVIHSVTRNWRSIAFTALLALILVYLF 2396

Query: 7786 SILGFLYFRHDFYLEVDPVEN---DSSATISSGI-PSETCPSEGCP-GLQPSX------- 7929
            SI+G+L+ + DF  EV+P+      ++AT  +G  P    P E CP GL+
Sbjct: 2397 SIVGYLFLQDDFVYEVNPLRPAIATATATNKTGTSPPMPLPPESCPAGLEMEDCLKNNLS 2456

Query: 7930 ----------XXXXXXXXXXXSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIW 8079
                                 +CETL M I+ T   G+R+GGGIGDVLR+P+  E +++
Sbjct: 2457 HVQAKEVSYDSGIEVGTERERACETLIMYIITTLNFGVRSGGGIGDVLRSPSTREPLYMA 2516

Query: 8080 RVAYDMTXXXXXXXXXXXXXXXXXXDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRS 8259
            RV YD+                   DTF DLR+EK +KE+ILKN CFICGL+RS FDN+S
Sbjct: 2517 RVIYDLLFFIVVIIIVLNLIFGVIIDTFADLRSEKQQKEEILKNTCFICGLNRSSFDNKS 2576

Query: 8260 VTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQD 8439
            V+FE H + EH++WHYLY+IV++++KD TEFTGPESYV    K++N DWFPRM+A+SL
Sbjct: 2577 VSFEEHYKEEHSMWHYLYFIVLVKVKDPTEFTGPESYVYNMTKEKNQDWFPRMRAMSLDS 2636

Query: 8440 SELDTDQSEVKQMKDQLLQMMTLMREIISQNEESRAFMEQ 8559
             E +++Q+E++ +++QL    +L++ +  Q  E +  M +
Sbjct: 2637 DEGESEQNEMRILQNQLENTNSLVKVLSGQLRELKDQMTE 2676


>gi|13591975|ref|NP_112308.1| inositol 1,4,5-triphosphate receptor 2;
            inositol 1,4,5-triphosphate receptor type 2; inositol
            triphosphate receptor type 2; inositol 145-triphosphate
            receptor 2; inositol 145-triphosphate receptor type 2
            [Rattus norvegicus]
 gi|266389|sp|P29995|IP3S_RAT Inositol 1,4,5-trisphosphate receptor
            type 2 (Type 2 inositol 1,4,5-trisphosphate receptor)
            (Type 2 InsP3 receptor) (IP3 receptor isoform 2)
            (InsP3R2)
 gi|111841|pir||S17796 inositol-trisphosphate receptor type 2 - rat
 gi|56508|emb|CAA43852.1| inositol triphosphate receptor type 2
            [Rattus norvegicus]
          Length = 2701

 Score = 1616 bits (4185), Expect = 0.0
 Identities = 1059/2910 (36%), Positives = 1558/2910 (53%), Gaps = 93/2910 (3%)
 Frame = +1

Query: 109  LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
            L+IGDI+SLY E S N    GF+STLGLVDDRC+V  + G   +PPKKFRDCLFKVCP+N
Sbjct: 9    LYIGDIVSLYAEGSVN----GFISTLGLVDDRCVVHPEAGDLTNPPKKFRDCLFKVCPMN 64

Query: 289  RYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQ 468
            RY+AQK  W  ++  Q   +  +  L+ KL+ AA+ E+++NESE +K LG +++Y  ++Q
Sbjct: 65   RYSAQKQYWKAKQAKQGNHT--EAALLKKLQHAAELEQKQNESENRKLLGEIVKYSKVIQ 122

Query: 469  LLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKI 648
            LLH+KSNKY+TV K  PA  E+NAM+V LD AGNEGSWF I P +K  + GDN+  G+K+
Sbjct: 123  LLHIKSNKYLTVNKRLPALLEKNAMRVSLDAAGNEGSWFYIHPFWKLRSEGDNIVVGDKV 182

Query: 649  SLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSV 828
             L+P       AG     LH S+  LLD+    EVN +N  T W++ +F+ F   +++ +
Sbjct: 183  VLMP-----VNAGQ---PLHASNVELLDNPGCKEVNAVNCNTSWKITLFMKFSSYREDVL 234

Query: 829  KSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTN 1008
            K GDVVRLFHA+Q+ FLT D   K+      +FLR T R SA  ATSS+ALWE++VV  +
Sbjct: 235  KGGDVVRLFHAEQEKFLTCDDYEKKQH----IFLRTTLRQSATSATSSKALWEIEVVHHD 290

Query: 1009 AYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRPPLLSALSQKSRPMLERTNN 1188
              RGG  +WN  +RFKHLAT  YL+AE +    + A N    +       S+   +
Sbjct: 291  PCRGGAGQWNSLFRFKHLATGNYLAAELNP-DYRDAQNEGKTVRDGELPTSKKKHQAGEK 349

Query: 1189 PMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEV 1368
             M      P+G                             D   LF+LD +T  +++  V
Sbjct: 350  IMYTLVSVPHG----------------------------NDIASLFELDATTLQRADCLV 381

Query: 1369 PRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKG-WVKVICEKNRVDKETFALLPVN 1545
            PR SYVRL H  ++ WV +T+      +   ++ E+   +K+   + + DKE FA++ V
Sbjct: 382  PRNSYVRLRHLCTNTWVTSTS------IPIDTEEERPVMLKIGTCQTKEDKEAFAIVCVP 435

Query: 1546 PDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADPL 1725
              EVRDLDFANDA K L   +K ++ G +   E     T+LL D I FV + +++  D L
Sbjct: 436  LSEVRDLDFANDANKVLATTVKKLENGSITQNER-RFVTKLLEDLIFFVADVTNNGQDVL 494

Query: 1726 KISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIFK 1905
             +    P+R+RQKL+REQ +L QVF +LKAPF  + G               D R   +K
Sbjct: 495  DVVITKPNRERQKLMREQNILAQVFGILKAPFKEKAGE----GSMLRLEDLGDQRYAPYK 550

Query: 1906 TMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYV 2085
             + +LCY +L++SQ  YRKNQE++A+ F  +Q QIG+D++AEDT+TA+LHNN KLLEK++
Sbjct: 551  YVLRLCYRVLRHSQQDYRKNQEYIAKNFCVMQSQIGYDILAEDTITALLHNNRKLLEKHI 610

Query: 2086 KTPHVERFVELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKI 2265
                +E FV L+R NR+ +FLDYL+DLCV    A    QELIC  +LS  + DI + TK+
Sbjct: 611  TAKEIETFVSLLRRNREPRFLDYLSDLCVSNSTAIPVTQELICKFMLSPGNADILIQTKL 670

Query: 2266 I------------------DGEIEVGWA-----PNFRKLVDIAEGAKSNSD-DAEHLDYY 2373
            +                  D E+ + W      P+ + +  +A+ A+  +  D E L YY
Sbjct: 671  VSMQVENPMESSILPDDIDDEEVWLYWIDSNKEPHGKAIRHLAQEAREGTKADLEVLTYY 730

Query: 2374 RHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLM 2553
            R+QL+L ++MC ++QYLAI+         IS QL  +L+L+C+SD  LP+DLR SF RLM
Sbjct: 731  RYQLNLFARMCLDRQYLAIN--------QISTQLSVDLILRCVSDESLPFDLRASFCRLM 782

Query: 2554 LHLHVVRGSPMSAI--RHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLA 2727
            LH+HV R    S +  R+ARLW  IP  + +  Y+S++     D SR  +    A   +
Sbjct: 783  LHMHVDRDPQESVVPVRYARLWTEIPTKITIHEYDSIT-----DSSRNDMKRKFA-LTME 836

Query: 2728 TVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIIN- 2904
             VE YL  + NQ          +KLT+E+V+LA+ L  F FYSF++LL+LT+ LLAI++
Sbjct: 837  FVEEYLKEVVNQPFPFGDK-EKNKLTFEVVHLARNLIYFGFYSFSELLRLTRTLLAILDI 895

Query: 2905 -EGPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAK-----------TPSVTAEEA 3048
             + P +          +   N+ +++   G       L++            PSV   +
Sbjct: 896  VQAPMSSYFERLSKFQDGSNNVMRTIHGVGEMMTQMVLSRGSIFPVSWPDAQPSVHPSKQ 955

Query: 3049 GRTKEGRALNVK-TKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSAS-- 3219
                E   + V  TKL V EILQF++ VR DYRI+  LS +K  F  + DG+   SAS
Sbjct: 956  ASPGEQEDVTVMDTKLKVIEILQFILSVRLDYRISYMLSIYKKEFG-ENDGNGDPSASGT 1014

Query: 3220 ------------INERMASELYDAIYRSSGHELHLDGRDGQLLLAILLQMTMSDYPPLTS 3363
                        I+E  A        R     + LD   G+  L +L+ + M DY PL S
Sbjct: 1015 PETLLPSALVPDIDEIAAQAETMFAGRKEKTPVQLDDEGGRTFLRVLIHLIMHDYAPLLS 1074

Query: 3364 IALKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDR 3543
             AL++ F+HF+Q  E+L+  KQVQLLVSN DV+NY+QI  DL  L+   EKSELWV
Sbjct: 1075 GALQLLFKHFSQRAEVLQAFKQVQLLVSNQDVDNYKQIKADLDQLRLTVEKSELWV---- 1130

Query: 3544 HHSIDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLN 3723
                                     +   ++++GD  E       E      NE   LL+
Sbjct: 1131 -------------------------EKSGSYENGDMGEGQAKGGEE-----ANEESNLLS 1160

Query: 3724 RLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNM 3903
             +       D A   Q  S+K     Y +++++L+RL+ +C +  + K    +Q+LLKNM
Sbjct: 1161 PV------QDGAKTPQIDSNKGN--NYRIVKEILIRLSKLCVQ--NKKCRNQHQRLLKNM 1210

Query: 3904 RVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEG 4083
              + VVL+ + +P++K  D  M +++ L+H FL++FC+ N +NQ  L+K ++       G
Sbjct: 1211 GAHSVVLDLLQIPYEKT-DEKMNEVMDLAHTFLQNFCRGNPQNQVLLHKHLNLF--LTPG 1267

Query: 4084 MLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYD 4263
            +L  ET+        IF NN  L + + E ++ H V  IE + R+  +L  LQ +V
Sbjct: 1268 LLEAETMRH------IFMNNYHLCNEISERVVQHFVHCIETHGRHVEYLRFLQTIVKADG 1321

Query: 4264 KEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIE 4443
            K ++  Q+ V  E+    ++V   Y D ASF  L  MM  E+       D    L YHI
Sbjct: 1322 KYVKKCQDMVMTELINGGEDVLIFYNDRASFPILLNMMCSERAR----GDESGPLAYHIT 1377

Query: 4444 LVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAE 4623
            LV LLA CT GKN  TE+KC S +P+D IVRVVT   C+ EVK  Y+  + HCY+DT+ E
Sbjct: 1378 LVELLAACTEGKNVYTEIKCNSLLPLDDIVRVVTHDDCIPEVKIAYVNFVNHCYVDTEVE 1437

Query: 4624 MKDAYKTEYVDHILNNLLEDIRSLRVEKLTGAETAT-LEHYICHTVTEVLIKFFEAPYSA 4800
            MK+ Y + ++  +  N L D+  +           T LE  +  +V  ++  FF +P+S
Sbjct: 1438 MKEIYTSNHIWKLFENFLVDMARVCNTTTDRKHADTFLERCVTESVMNIVSGFFNSPFS- 1496

Query: 4801 LQQAKVDVHHHKKTFSEVLLELTYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNITL 4980
                   +  H+  F ++L     +            +   V  CI+ L + A+   I +
Sbjct: 1497 --DNSTSLQTHQPVFIQLLQSAFRIYNCTWPNPAQKAS---VESCIRALAEVAKNRGIAI 1551

Query: 4981 PATLAGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHTSA 5160
            P  L     S   ++  K    +S+ +   +G RL+ ++       L G +
Sbjct: 1552 PVDLD----SQVNTLFMK--NHSSTVQRAAMGWRLSARSGPRFKEALGGPAWDYR----- 1600

Query: 5161 NVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQ 5340
            N++     ++   +    P+  AE SVLV+VL++PELLFPEGS  R +C  G  ++KLI
Sbjct: 1601 NIIEKLQDVVASLEQQFSPMMQAEFSVLVDVLYSPELLFPEGSDARIRC--GAFMSKLIN 1658

Query: 5341 HCKTLMQNKQDNLCARVLQTLCKMCDCTKQQLTHQGHRVYNSSVEKGXXXXXXXXXXYF- 5517
            H K LM+ K++ LC ++LQTL +M +              +S +E+           YF
Sbjct: 1659 HTKKLME-KEEKLCIKILQTLREMLEKK------------DSFMEESSTLRKILLNRYFK 1705

Query: 5518 -GHHNNHHPPLDRQQSXXXXXXXXXXXXXXXTWSQERD-----LYAIQCKLNDAGASDLV 5679
              H    + PL    +                  Q+ D     +  IQC L+  GAS+LV
Sbjct: 1706 GDHSVGVNGPLSGAYAKTAQVGGGFT-------GQDADKTGISMSDIQCLLDKEGASELV 1758

Query: 5680 TDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQ 5859
             D+I+   +  IF + I L  ALL  GN + Q+SFY ++ ++   E FFK +  R++ AQ
Sbjct: 1759 IDVIVNTKNDRIFSEGILLGIALLEGGNTQTQNSFYQQLHEQKKSEKFFKVLYDRMKAAQ 1818

Query: 5860 NRLKSDM----MSCSDSKPKVSSTVLT--PLIDAGDT------GFNGALFEVPQQVRHPS 6003
              ++S +    +     K +  S ++   P +   D+      G  G L E
Sbjct: 1819 KEIRSTVTVNTIDLGSKKREEDSDLMALGPRMRVRDSSLHLKEGMKGQLTEASSATSKAY 1878

Query: 6004 ISEMSQLSNDLTHSIPDLAPYQDEEKSTD--ALPPEVALVEPILRVLQLLCENHNSLLQN 6177
                 ++  D+    P       EEKS +   + P + ++ PILR LQLLCENHN  LQN
Sbjct: 1879 CVYRREMDPDIDTMCPGQEAGSAEEKSAEEVTMSPAITIMRPILRFLQLLCENHNRELQN 1938

Query: 6178 FLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFG-EIGEHNFSLITQTLATLTEFCQG 6354
            FLR Q+++TN+NLV ETL FLD +CGST G LG+ G  I E N +L+ QTL +LTE+CQG
Sbjct: 1939 FLRNQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINEKNVALVNQTLESLTEYCQG 1998

Query: 6355 PCHENQNTMAMQE-NGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIMESRHDG 6531
            PCHENQ  +A  E NG++III+L+L++I PL    M+L L+
Sbjct: 1999 PCHENQTCIATHESNGIDIIIALILSDINPLGKYRMDLVLQ------------------- 2039

Query: 6532 ENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLKKKSGPQ 6711
                  L+N A+     K L+  ++  ++  N+   +     ++L      D+ K +  Q
Sbjct: 2040 ------LKNNAS-----KLLLAIMESRHDSENAERILFNMRPKELV-----DVMKNAYNQ 2083

Query: 6712 ITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNIYILAHQLA 6891
                            G+   H         D++  DD    V P++VGHNIYILAHQLA
Sbjct: 2084 ----------------GLECNHG--------DEEGGDD---GVSPKDVGHNIYILAHQLA 2116

Query: 6892 IHDGELEIWLD-GSDEKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPINDICSYLT 7068
             H+  L+  L  GSD ++ D   EAL YY   TAQIEIVR DRT+E++VFP+ +IC +LT
Sbjct: 2117 RHNKLLQQMLKPGSDPEEGD---EALKYYANHTAQIEIVRHDRTMEQIVFPVPNICEFLT 2173

Query: 7069 KDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPLWTRLS 7248
            +++K  V+N TERD QGSKV +FF + E +Y+EM WQ+K+++   L W +  + LW  +S
Sbjct: 2174 RESKYRVFNTTERDEQGSKVNDFFQQTEDLYNEMKWQKKIRNNPALFWFSRHISLWGSIS 2233

Query: 7249 FHFAFIVNALVARYYPLPEHSNSSISLGNLYS---WFAV-FSSFLLAHYLRHDKIYLHKT 7416
            F+ A  +N  VA +YP  +  +   +L  L+S   W AV   + +L  + +   I
Sbjct: 2234 FNLAVFINLAVALFYPFGDDGDEG-TLSPLFSALLWVAVAICTSMLFFFSKPVGI----- 2287

Query: 7417 XXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRNL 7596
                           IG+  TL + G   L NKIV +V+FV N+G   R    ++
Sbjct: 2288 -RPFLVSIMLRSIYTIGLGPTLILLGAANLCNKIVFLVSFVGNRGTFTRGYRAVILDMAF 2346

Query: 7597 HYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALILL 7776
             Y + Y+ +C+LGL VH   Y  LLFD+++ EETL NVI SVTRN +SI+ T +LALIL+
Sbjct: 2347 LYHVAYVLVCMLGLFVHEFFYSFLLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILV 2406

Query: 7777 YFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSET-------CPSEGCPGLQPSXXX 7935
            Y FSI+GFL+ + DF +EVD ++N +  T + G+P+ T       CP E C    PS
Sbjct: 2407 YLFSIIGFLFLKDDFTMEVDRLKNRTPVTGNDGVPTMTLTSMLGTCPKENCSPTIPSSNA 2466

Query: 7936 XXXXXXXXX--SCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTXXX 8109
                       +C+TL MCI+    QGLRNGGG+GDVLR P+  E +F  RV YD+
Sbjct: 2467 AGEGGEDGIERTCDTLLMCIVTVLNQGLRNGGGVGDVLRRPSKDEPLFAARVVYDLLFFF 2526

Query: 8110 XXXXXXXXXXXXXXXDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETE 8289
                           DTF DLR+EK +KE+ILK  CFICGL+R +FDN++V+FE H ++E
Sbjct: 2527 IVIIIVLNLIFGVIIDTFADLRSEKQKKEKILKTTCFICGLERDKFDNKTVSFEEHIKSE 2586

Query: 8290 HNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEV 8469
            HN+WHYLY+IV++++KD TE+TGPESYVAQ + ++NLDWFPRM+A+SL  +E D++Q+E+
Sbjct: 2587 HNMWHYLYFIVLVKVKDPTEYTGPESYVAQMITEKNLDWFPRMRAMSLVSNEGDSEQNEI 2646

Query: 8470 KQMKDQLLQMMTLMREIISQNEESRAFMEQ 8559
            + ++++L   M+L++++  Q  E +  M +
Sbjct: 2647 RNLQEKLESTMSLVKQLSGQLAELKEQMTE 2676


>gi|27807313|ref|NP_777266.1| inositol 1,4,5-triphosphate receptor,
            type 1 [Bos taurus]
 gi|17367101|sp|Q9TU34|IP3R_BOVIN Inositol 1,4,5-trisphosphate
            receptor type 1 (Type 1 inositol 1,4,5-trisphosphate
            receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform
            1) (InsP3R1)
 gi|6006803|gb|AAF00613.1| inositol 1,4,5-trisphosphate receptor type
            I [Bos taurus]
          Length = 2709

 Score = 1612 bits (4174), Expect = 0.0
 Identities = 1067/2912 (36%), Positives = 1556/2912 (52%), Gaps = 108/2912 (3%)
 Frame = +1

Query: 109  LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
            LHIGDI SLY E S+N    GF+STLGLVDDRC+V+ + G   +PPKKFRDCLFK+CP+N
Sbjct: 9    LHIGDICSLYAEGSTN----GFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKLCPMN 64

Query: 289  RYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQ 468
            RY+AQK  W   K     +S  D  L+NKL  AAD E+++NE+E +K LG VIQYG+++Q
Sbjct: 65   RYSAQKQFWKAAK--PGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQ 122

Query: 469  LLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKI 648
            LLH+KSNKY+TV K  PA  E+NAM+V LD AGNEGSWF I+P YK  +IGD+V  G+K+
Sbjct: 123  LLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGDKV 182

Query: 649  SLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSV 828
             L P       AG     LH SS  L+D+    EVN +N  T W++ +F+ + +N+ + +
Sbjct: 183  VLNP-----VNAGQ---PLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDIL 234

Query: 829  KSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTN 1008
            K GDVVRLFHA+Q+ FLT D   K+      VFLR T R SA  ATSS+ALWEV+VVQ +
Sbjct: 235  KGGDVVRLFHAEQEKFLTCDEHRKKQH----VFLRTTGRQSATSATSSKALWEVEVVQHD 290

Query: 1009 AYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRPPLLSALSQKSRPMLERTNN 1188
              RGG   WN  +RFKHLAT  YL+AE      +  +  +P +       SR  L
Sbjct: 291  PCRGGAGYWNSLFRFKHLATGHYLAAEVDPDFEEECLEFQPSV-DPDQDASRSRLRNAQE 349

Query: 1189 PMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPE-EDANLLFQLDPSTFMKSNKE 1365
             M +YS                 + SV          PE  D + +F+LDP+T    +
Sbjct: 350  KM-VYS-----------------LVSV----------PEGNDISSIFELDPTTLRGGDSL 381

Query: 1366 VPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKG-WVKVICEKNRVDKETFALLPV 1542
            VPR SYVRL H  ++ WVH+TN      +    + EK   +K+     + DKE FA++PV
Sbjct: 382  VPRNSYVRLRHLCTNTWVHSTN------IPIDKEEEKPVMLKIGTSPVKEDKEAFAIVPV 435

Query: 1543 NPDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADP 1722
            +P EVRDLDFANDA K L +    ++ G +   E   S T+LL D + FVT  ++   D
Sbjct: 436  SPAEVRDLDFANDASKVLGSIAGKLEKGTITQNER-RSVTKLLEDLVYFVTGGTNSGQDV 494

Query: 1723 LKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIF 1902
            L++    P+R+RQKL+REQ +L Q+F LL+APF     T              D R+  F
Sbjct: 495  LEVVFSKPNRERQKLMREQNILKQIFKLLQAPF-----TDCGDGPMLRLEELGDQRHAPF 549

Query: 1903 KTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKY 2082
            + + +LCY +L++SQ  YRKNQE++A++FG +Q+QIG+D++AEDT+TA+LHNN KLLEK+
Sbjct: 550  RHICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKH 609

Query: 2083 VKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTK 2262
            +    ++ FV LVR NR+ +FLDYL+DLCV   ++    QELIC +VL+  + DI ++TK
Sbjct: 610  ITAAEIDTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETK 669

Query: 2263 II---------------------DGEIEVGWAPNFRKLV-----DIAEGAKSNS-DDAEH 2361
            ++                     + E+ V W  + +++      ++A+ AK    +D +
Sbjct: 670  LVLSRFEFEGVSTGENALEAGEDEEEVWVFWRDSNKEVRSKSVRELAQDAKEGQKEDRDV 729

Query: 2362 LDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSF 2541
            L YYR+QL+L ++MC ++QYLAI+         IS QL  +L+L+CMSD  LP DLR SF
Sbjct: 730  LGYYRYQLNLFARMCLDRQYLAIN--------EISGQLDVDLILRCMSDENLPSDLRASF 781

Query: 2542 TRLMLHLHVVRG--SPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAH 2715
             RLMLH+HV R     ++ +++ARLW  IP  + +  Y+S      S  S+  I E  A
Sbjct: 782  CRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDS------SGTSKDEIKERFA- 834

Query: 2716 KVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLA 2895
            + +  VE YL  +  Q          +KLT+E+VNLA+ L  F FY+F+DLL+LT+ LLA
Sbjct: 835  QTMEFVEEYLRDVVCQRFPFSDK-EKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLA 893

Query: 2896 IINEGPATEQVPSHRAMV-------NAIRN-------MSKSMMRGGNKENSKDLAKTPSV 3033
            I++    T   P  +          N +R+       M++ ++RGG        A  P
Sbjct: 894  ILDCVHVTTIFPISKMAKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPTATAPEG 953

Query: 3034 TAEEAGRTKEGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFP---------- 3183
              ++A   KE   + + TKL + EILQF+++VR DYRI+  L  FK  F
Sbjct: 954  NVKQAEPEKED-IMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQTSETS 1012

Query: 3184 ---CDEDGSLMHSASINERMASELYDAIYRSSGHE--LHLDGRDGQLLLAILLQMTMSDY 3348
                 ++G      +++     E  + I+  S     L LD   G+  L +LL +TM DY
Sbjct: 1013 SGNSSQEGPSNVPGALDFEHIEEQAEGIFGGSEETTPLDLDDHGGRTFLRVLLHLTMHDY 1072

Query: 3349 PPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELW 3528
            PPL S AL++ FRHF+Q QE+L+  KQVQLLV++ DV+NY+QI +DL
Sbjct: 1073 PPLVSGALQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDL------------- 1119

Query: 3529 VHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNEC 3708
               D+  SI  K           +L  +  + P     G S E      NEH  +
Sbjct: 1120 ---DQLRSIVEKS----------ELWVYKGQGPDEAMDGASGE------NEHKKT----- 1155

Query: 3709 LQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDP--KPDTMN 3882
                      ++ N+ +   +  S       Y +++++L+RL+ +C ++     K
Sbjct: 1156 ----------EEGNNKSQQHESTSS----YNYRVVKEILIRLSKLCVQESASVRKSRKQQ 1201

Query: 3883 QQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFISY 4062
            Q+LL+NM  + VVLE + +P++K  D  M +++ L+HEFL++FC  N  NQ+ L+K I+
Sbjct: 1202 QRLLRNMGAHAVVLELLQIPYEKAEDTMMQEIMRLAHEFLQNFCAGNHPNQALLHKHINL 1261

Query: 4063 EKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQ 4242
              +   G+L   T++       IF NN +L S + E ++ H V  IE + RN  +++ LQ
Sbjct: 1262 FLNP--GILEAVTMQH------IFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQ 1313

Query: 4243 ALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSDSRR 4422
             +V    K I+  Q+ V  E+  + ++V   Y D ASF+ L  MM+ E++      D
Sbjct: 1314 TIVKAEGKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERDRM----DENS 1369

Query: 4423 KLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHC 4602
             L YHI LV LLA+CT GKN  TE+KC S +P+D IVRVVT + C+ EVK  Y+  L HC
Sbjct: 1370 PLMYHIHLVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHC 1429

Query: 4603 YIDTDAEMKDAYKTEYVDHILNNLLEDI-RSLRVEKLTGAETATLEHYICHTVTEVLIKF 4779
            Y+D + EMK+ Y + ++  +  N L DI R+           + LE Y+   V  ++  F
Sbjct: 1430 YVDPEVEMKEIYTSNHMWKLFENFLVDICRACNNTSDRKHADSILEKYVTEIVMSIVTTF 1489

Query: 4780 FEAPYSALQQAKVDVHHHKKTFSEVLLEL--TYLEKGKLRGSKSSRNWYRVAECIKRLTK 4953
            F +P+S        +   +  F ++L  +   Y     +   K+S     V  CI+ L+
Sbjct: 1490 FSSPFS---DQSTTLQTRQPVFVQLLQGVFRVYHCNWLMPSQKAS-----VESCIRVLSD 1541

Query: 4954 WAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGHRLYGTS 5133
             A+   I +P  L     +         Q+ A +  W    +   R++++ P  R Y
Sbjct: 1542 VAKSRAIAIPVDLDSQVNNLFLKSHNLVQKTAMN--WRLTARNAARRDSVLPVSRDY--- 1596

Query: 5134 NSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCAR 5313
                     N++     ++   +  L PL  AE SVLV+VLH PELLFPE +  R +C
Sbjct: 1597 --------RNIIERLQDIVSALEDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKCES 1648

Query: 5314 GGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKQQLTHQGHRVYNSSVEKGXXXX 5493
            GG + KLI+H K L++  ++ LC +VLQTL +M   TK        R Y    EKG
Sbjct: 1649 GGFICKLIKHTKQLLEENEEKLCIKVLQTLREMM--TKD-------RGYG---EKGEALR 1696

Query: 5494 XXXXXXYFGHHNNHHPPLDRQQSXXXXXXXXXX-------------XXXXXTWSQERDLY 5634
                  Y+G+      P  R++S                                E  L
Sbjct: 1697 QILVNRYYGNIR----PSGRRESLTSFGNGPLSPGGPSKPGGGGGGSGSSPMSRGEMSLA 1752

Query: 5635 AIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIH 5814
             +QC L+  GAS+LV D+I+   S  +F ++I LA ALL  GN  +QHSF+ R+ +
Sbjct: 1753 EVQCHLDKEGASNLVIDLIMNASSDRVFHESILLAIALLEGGNTTIQHSFFCRLTEDKKS 1812

Query: 5815 EPFFKAILTRIQTAQNRLKSDM-MSCSDSKPKVSSTVL---TPLIDAGDTGFNGALFEVP 5982
            E FFK    R++ AQ  +K+ + ++ SD   K     +    P              EV
Sbjct: 1813 EKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPATQITEEVR 1872

Query: 5983 QQVRHPSISEMSQLSNDLTHSIPDLAPYQDEE-------KSTDALPPE--VALVEPILRV 6135
             Q+   S +     +     + PD   YQ  E       KS D L     + +++PILR
Sbjct: 1873 DQLLEASAATRKAFTTFRREADPD-DHYQSGEGAQAAADKSKDDLEMSAVITIMQPILRF 1931

Query: 6136 LQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFG-EIGEHNFSL 6312
            LQLLCENHN  LQNFLR Q+++TN+NLV ETL FLD +CGST G LG+ G  I E N +L
Sbjct: 1932 LQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINEKNVAL 1991

Query: 6313 ITQTLATLTEFCQGPCHENQNTMAMQE-NGLNIIISLVLNEIKPLADDHMELALEIKSQA 6489
            I QTL +LTE+CQGPCHENQN +A  E NG++II +L+LN              +I
Sbjct: 1992 INQTLESLTEYCQGPCHENQNCIATHESNGIDIITALILN--------------DINPLG 2037

Query: 6490 SKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDLF 6669
             K +  ++E           L+N A+     K L+  ++  ++  N+   +     ++L
Sbjct: 2038 KKRMDLVLE-----------LKNNAS-----KLLLAIMESRHDSENAERILYNMRPKELV 2081

Query: 6670 RQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDPR 6849
                 ++ KK+  Q  V                            +D  N +D  +  PR
Sbjct: 2082 -----EVIKKAYMQGEVE--------------------------FEDGENGED-GAASPR 2109

Query: 6850 EVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTLER 7029
             VGHNIYILAHQLA H+ EL+  L    +   D   E L++Y + T   EIVR DRT+E+
Sbjct: 2110 NVGHNIYILAHQLARHNKELQTMLKPGGQVDGD---ETLDFYAQPTGPNEIVRLDRTMEQ 2166

Query: 7030 VVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWLS 7209
            +VFP+  IC +LTK++K  +Y  TERD QGSK+ +FF   E +++EM WQ+KL+ +  L
Sbjct: 2167 IVFPVPSICEFLTKESKLRIYYTTERDEQGSKINDFFLRSEDLFNEMNWQKKLRAQPVLY 2226

Query: 7210 WCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSIS---LGNLYSWFAVFSSFLLAH 7380
            WCA  +  W+ +SF+ A ++N LVA +YP       ++     G L++   +  + ++A
Sbjct: 2227 WCARNMSFWSSISFNLAVLMNLLVAFFYPFKGVRGGTLEPHWSGLLWTAMLISLAIVIAL 2286

Query: 7381 YLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLED 7560
               H                       +G+  TL++ G   + NKI+ +++FV N G
Sbjct: 2287 PKPHG-------IRALIASTILRLIFSVGLQPTLFLLGAFNVCNKIIFLMSFVGNCGTFT 2339

Query: 7561 RPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQS 7740
            R    ++      Y L+ L IC +GL VH   Y +LLFD+++ EETL NVI SVTRN +S
Sbjct: 2340 RGYRAMVLDVEFLYHLLXLLICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRS 2399

Query: 7741 IVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSS------ATISSGIPSETC--- 7893
            I+   +LALIL+Y FSI+G+L+F+ DF LEVD + N++S      +  S  + S+ C
Sbjct: 2400 IILMAVLALILVYLFSIVGYLFFKDDFILEVDRLPNETSLPEASESLASEFLYSDVCRVE 2459

Query: 7894 PSEGCPGLQPSXX---XXXXXXXXXXSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWE 8064
              E C    P                +CETL MCI+     GLR+GGG+GDVLR P+  E
Sbjct: 2460 TGENCSSPAPKEELVPAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEE 2519

Query: 8065 DMFIWRVAYDMTXXXXXXXXXXXXXXXXXXDTFGDLRAEKNEKEQILKNNCFICGLDRSR 8244
             +F  RV YD+                   DTF DLR+EK +KE+ILK  CFICGL+R +
Sbjct: 2520 PLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDK 2579

Query: 8245 FDNRSVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQA 8424
            FDN++VTFE H + EHN+WHYL +IV++++KD TE+TGPESYVA+ +K+RNLDWFPRM+A
Sbjct: 2580 FDNKTVTFEEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFPRMRA 2639

Query: 8425 LSLQDSELDTDQSEVKQMKDQLLQMMTLMREI 8520
            +SL  S+ + +Q+E++ ++++L   M L+  +
Sbjct: 2640 MSLVSSDSEGEQNELRNLQEKLESTMKLVTNL 2671


>gi|4504795|ref|NP_002215.1| inositol 1,4,5-triphosphate receptor,
            type 3 [Homo sapiens]
 gi|1082540|pir||A49873 inositol 1,4,5-triphosphate receptor, type 3 -
            human
 gi|393036|gb|AAC50064.1| human type 3 inositol 1,4,5-trisphosphate
            receptor
          Length = 2671

 Score = 1582 bits (4097), Expect = 0.0
 Identities = 1047/2917 (35%), Positives = 1557/2917 (52%), Gaps = 96/2917 (3%)
 Frame = +1

Query: 109  LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
            LHIGDI+SLY E S N    GF+STLGLVDDRC+VE   G  ++PPKKFRDCLFKVCP+N
Sbjct: 8    LHIGDIVSLYAEGSVN----GFISTLGLVDDRCVVEPAAGDLDNPPKKFRDCLFKVCPMN 63

Query: 289  RYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQ 468
            RY+AQK  W  ++  Q  + + D  L+ KL+ AA  E+++N++E +K  G+V++YGS++Q
Sbjct: 64   RYSAQKQYWKAKQTKQDKEKIADVVLLQKLQHAAQMEQKQNDTENKKVHGDVVKYGSVIQ 123

Query: 469  LLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKI 648
            LLH+KSNKY+TV K  PA  E+NAM+V LD  GNEGSW  I+P +K  + GDNV  G+K+
Sbjct: 124  LLHMKSNKYLTVNKRLPALLEKNAMRVTLDATGNEGSWLFIQPFWKLRSNGDNVVVGDKV 183

Query: 649  SLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSV 828
             L P       AG     LH S++ L D+    EVN +N  T W++ +F+ F ++ +  +
Sbjct: 184  ILNP-----VNAGQ---PLHASNYELSDNAGCKEVNSVNCNTSWKINLFMQFRDHLEEVL 235

Query: 829  KSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTN 1008
            K GDVVRLFHA+Q+ FLT D    +      VFLR T R SA  ATSS ALWEV+VV  +
Sbjct: 236  KGGDVVRLFHAEQEKFLTCDEYKGKLQ----VFLRTTLRQSATSATSSNALWEVEVVHHD 291

Query: 1009 AYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRPPLLSALSQKSRPMLERTNN 1188
              RGG   WN  YRFKHLAT  YL+AE +     P+  G                   ++
Sbjct: 292  PCRGGAGHWNGLYRFKHLATGNYLAAEEN-----PSYKGD-----------------ASD 329

Query: 1189 PMA--MYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNK 1362
            P A  M + G  G  N       + I    V  P  ++        LF+LDP+T  K++
Sbjct: 330  PKAAGMGAQGRTGRRNAG-----EKIKYCLVAVPHGNDIAS-----LFELDPTTLQKTDS 379

Query: 1363 EVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWVKVICEKNRVDKETFALLPV 1542
             VPR SYVRL H  ++ W+ +TN      +    +     +   C   + DKE FA++ V
Sbjct: 380  FVPRNSYVRLRHLCTNTWIQSTNVP----IDIEEERPIRLMLGTCP-TKEDKEAFAIVSV 434

Query: 1543 NPDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADP 1722
               E+RDLDFANDA   L + ++ +  G  IS+       QLL D + FV++  ++  +
Sbjct: 435  PVSEIRDLDFANDASSMLASAVEKLNEG-FISQNDRRFVIQLLEDLVFFVSDVPNNGQNV 493

Query: 1723 LKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIF 1902
            L I    P+R+RQKL+REQ +L QVF +LK PF  + G               D +N  +
Sbjct: 494  LDIMVTKPNRERQKLMREQNILKQVFGILKVPFREKGGE----GPLVRLEELSDQKNAPY 549

Query: 1903 KTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKY 2082
            + MF+LCY +L+YSQ  YRKNQE +A++FG +Q QIG+D++AEDT+TA+LHNN KLLEK+
Sbjct: 550  QHMFRLCYRVLRYSQEDYRKNQEHIAKQFGMMQSQIGYDILAEDTITALLHNNRKLLEKH 609

Query: 2083 VKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTK 2262
            +    VE FV LVR NR+ +FLDYL+DLCV    A    QELIC  VL  K+ DI + T+
Sbjct: 610  ITKTEVETFVSLVRKNREPRFLDYLSDLCVSNHIAIPVTQELICKCVLDPKNSDILIRTE 669

Query: 2263 I-----------------IDGEIEVGWAP-----NFRKLVDIAEGAKS-NSDDAEHLDYY 2373
            +                  + E+ + W       + + +  +A+ A++ N+ D   L YY
Sbjct: 670  LRPVKEMAQSHEYLSIEYSEEEVWLTWTDKNNEHHEKSVRQLAQEARAGNAHDENVLSYY 729

Query: 2374 RHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLM 2553
            R+QL L ++MC ++QYLAID         ISQQL  +L+  CM+D  LP+DLR SF  LM
Sbjct: 730  RYQLKLFARMCLDRQYLAID--------EISQQLGVDLIFLCMADEMLPFDLRASFCHLM 781

Query: 2554 LHLHVVRGSP--MSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLA 2727
            LH+HV R     ++ ++ ARLW  IP  + +  Y+S ++ A  D  + +         +
Sbjct: 782  LHVHVDRDPQELVTPVKFARLWTEIPTAITIKDYDS-NLNASRDDKKNKFA-----NTME 835

Query: 2728 TVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIIN- 2904
             VE YL  + ++++        +KLT+E+V+LA  L  F FYSF++LL+LT+ LL II+
Sbjct: 836  FVEDYLNNVVSEAVPFANE-EKNKLTFEVVSLAHNLIYFGFYSFSELLRLTRTLLGIIDC 894

Query: 2905 -EGPATEQVPSHRAMVNAI-----RNMSKSMMRGGNKENSKDLAKTPSV----------- 3033
             +GP         AM+ A      +N+ +S+   G+  ++  L++  SV
Sbjct: 895  VQGPP--------AMLQAYEDPGGKNVRRSIQGVGHMMSTMVLSRKQSVFSAPSLSAGAS 946

Query: 3034 TAEEAGRTK--EGRALNV-KTKLIVAEILQFVMDVRRDYRITMALSWFK----NVFPCDE 3192
             AE   R+K  E   + V +TKL + EILQF+++VR DYRI+  LS FK     VFP  +
Sbjct: 947  AAEPLDRSKFEENEDIVVMETKLKILEILQFILNVRLDYRISYLLSVFKKEFVEVFPMQD 1006

Query: 3193 DGS-------LMHSASINERMASELYDAIY--RSSGHELHLDGRDGQLLLAILLQMTMSD 3345
             G+          +A++N     E  +A++    +   L +D   G++ L +L+ +TM D
Sbjct: 1007 SGADGTAPAFDSTTANMNLDRIGEQAEAMFGVGKTSSMLEVDDEGGRMFLRVLIHLTMHD 1066

Query: 3346 YPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSEL 3525
            Y PL S AL++ F+HF+Q QE +   KQVQLL+S  DVENY+ I  +L  L+ + EKSEL
Sbjct: 1067 YAPLVSGALQLLFKHFSQRQEAMHTFKQVQLLISAQDVENYKVIKSELDRLRTMVEKSEL 1126

Query: 3526 WVHGDRHHSIDTKEV------DEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHY 3687
            WV  D+  S   +EV      D+KER T+ +   H    P    S ++ + +  +L
Sbjct: 1127 WV--DKKGSGKGEEVEAGTAKDKKERPTDEEGFLH----PPGEKSSENYQIVKGILE--- 1177

Query: 3688 PSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDPK 3867
                                                           RL  MC   G  +
Sbjct: 1178 -----------------------------------------------RLNKMC---GVGE 1187

Query: 3868 PDTMNQQ-LLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRL 4044
                 QQ LLKNM  ++V+L+ + +P+D K D  MM+++  +H+FL+ FC  N  NQ+ L
Sbjct: 1188 QMRKKQQRLLKNMDAHKVMLDLLQIPYD-KGDAKMMEILRYTHQFLQKFCAGNPGNQALL 1246

Query: 4045 YKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPI 4224
            +K +        G+L  ET++       IF NN +L S + E ++ H V L+  + R+
Sbjct: 1247 HKHL--HLFLTPGLLEAETMQH------IFLNNYQLCSEISEPVLQHFVHLLATHGRHVQ 1298

Query: 4225 FLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGR 4404
            +L+ L  ++    K ++  Q+ +  E+  A D+V   Y D AS   L  MMK  ++
Sbjct: 1299 YLDFLHTVIKAEGKYVKKCQDMIMTELTNAGDDVVVFYNDKASLAHLLDMMKAARD---- 1354

Query: 4405 SSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYL 4584
              +    L YHI LV LLA C  GKN  TE+KC S +P++ +V VVT + C+ EVK  Y+
Sbjct: 1355 GVEDHSPLMYHISLVDLLAACAEGKNVYTEIKCTSLVPLEDVVSVVTHEDCITEVKMAYV 1414

Query: 4585 QLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEKLTGAETATLEHYICHTVTE 4764
              + HCY+DT+ EMK+ Y + ++  +  N   D+  +  ++       TLE Y+   V +
Sbjct: 1415 NFVNHCYVDTEVEMKEIYTSNHIWTLFENFTLDMARVCSKREKRVADPTLEKYVLSVVLD 1474

Query: 4765 VLIKFFEAPYSALQQAKVDVHHHKKTFSEV------LLELTYLEKGKLRGSKSSRNWYRV 4926
             +  FF +P+S   +    +  H+    ++      LLE  +L++ + +GS        V
Sbjct: 1475 TINAFFSSPFS---ENSTSLQTHQPVVVQLLQSTTRLLECPWLQQ-QHKGS--------V 1522

Query: 4927 AECIKRLTKWAEEHNITLPATL---AGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQN 5097
              CI+ L   A+   I LP  L       +S   S     Q+ ASS K
Sbjct: 1523 EACIRTLAMVAKGRAILLPMDLDAHISSMLSSGASCAAAAQRNASSYK-----------A 1571

Query: 5098 TLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLF 5277
            T     R+  T+N   +    N++     +I   +  L PL  AE SVLV+VLH PELLF
Sbjct: 1572 TTRAFPRVTPTAN---QWDYKNIIEKLQDIITALEERLKPLVQAELSVLVDVLHWPELLF 1628

Query: 5278 PEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKQQLTHQGHRV 5457
             EGS    +C  GG ++KLIQH K LM++ ++ LC +VL+TL +M    K +   +G+++
Sbjct: 1629 LEGSEAYQRCESGGFLSKLIQHTKDLMES-EEKLCIKVLRTLQQML-VKKTKYGDRGNQL 1686

Query: 5458 YNSSVEKGXXXXXXXXXXYFGHHNNHHPPLDRQQSXXXXXXXXXXXXXXXTWSQERDLYA 5637
                ++                        +R+ +                WS    + A
Sbjct: 1687 RKMLLQNYLQ--------------------NRKSTSRGDLPDPIGTGLDPDWSA---IAA 1723

Query: 5638 IQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHE 5817
             QC+L+  GA+ LV D+I    + +IF ++I LA  LL  GN ++Q SF+  M      E
Sbjct: 1724 TQCRLDKEGATKLVCDLITSTKNEKIFQESIGLAIHLLDGGNTEIQKSFHNLMMSDKKSE 1783

Query: 5818 PFFKAILTRIQTAQNRLKSDM---MSCSDSKPKVSSTVLTPLIDAGDTGFNGALFEVPQQ 5988
             FFK +  R++ AQ   KS +   M+   S+P      + P      T    A F +P
Sbjct: 1784 RFFKVLHDRMKRAQQETKSTVAVNMNDLGSQPHEDREPVDP-----TTKGRVASFSIPGS 1838

Query: 5989 VRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPEVALVEPILRVLQLLCENHNSL 6168
                S+    +  ++++  +      Q  E  T  L     +++PILR LQLLCENHN
Sbjct: 1839 SSRYSLGPSLRRGHEVSERV------QSSEMGTSVL-----IMQPILRFLQLLCENHNRD 1887

Query: 6169 LQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFG-EIGEHNFSLITQTLATLTEF 6345
            LQNFLR Q+++TN+NLV ETL FLD +CGST G LG+ G  I E N  L+ QTL TLTE+
Sbjct: 1888 LQNFLRCQNNKTNYNLVCETLQFLDIMCGSTTGGLGLLGLYINEDNVGLVIQTLETLTEY 1947

Query: 6346 CQGPCHENQNTMAMQE-NGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIMESR 6522
            CQGPCHENQ  +   E NG++II +L+LN+I PL    M+L L++K  ASKLLLA+MESR
Sbjct: 1948 CQGPCHENQTCIVTHESNGIDIITALILNDISPLCKYRMDLVLQLKDNASKLLLALMESR 2007

Query: 6523 HDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLKKKS 6702
            HD ENA R+L     +S  P++LV  IK+AY                   Q E+    +
Sbjct: 2008 HDSENAERIL-----ISLRPQELVDVIKKAY------------------LQEEERENSEV 2044

Query: 6703 GPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNIYILAH 6882
             P+   + + +  + +        H  K +    +++                    ++
Sbjct: 2045 SPREVGHNIYILALQLSRHNKQLQHLLKPVKRIQEEEAEG-----------------ISS 2087

Query: 6883 QLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPINDICSY 7062
             L++++ +L   L  S   +++   + L YY+  T+QIEIVR+DR++E++VFP+  IC +
Sbjct: 2088 MLSLNNKQLSQMLKSSAPAQEE-EEDPLAYYENHTSQIEIVRQDRSMEQIVFPVPGICQF 2146

Query: 7063 LTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPLWTR 7242
            LT++TK  ++  TE+D QGSKV++FFD+   +++EM WQR ++    + W + R+ LW
Sbjct: 2147 LTEETKHRLFTTTEQDEQGSKVSDFFDQSSFLHNEMEWQRNVRSMPLIYWFSRRMTLWGS 2206

Query: 7243 LSFHFAFIVNALVARYYPLPEHSNSSI---SLGNLYSWFAVFSSFLLAHYLRHDKIYLHK 7413
            +SF+ A  +N ++A +YP  E +++ +    L +L  W  +  S       R+
Sbjct: 2207 ISFNLAVFINIIIAFFYPYMEGASTGVLDSPLISLLFWILICFSIAALFTKRY------- 2259

Query: 7414 TXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRN 7593
            +               +G+  TL I G L L NKIV VV+FV N+G   R    ++
Sbjct: 2260 SIRPLIVALILRSIYYLGIGPTLNILGALNLTNKIVFVVSFVGNRGTFIRGYKAMVMDME 2319

Query: 7594 LHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALIL 7773
              Y + Y+   +LGL  H + Y ILLFD+I+ EETL NVI SVTRN +SI+ T LLALIL
Sbjct: 2320 FLYHVGYILTSVLGLFAHELFYSILLFDLIYREETLFNVIKSVTRNGRSILLTALLALIL 2379

Query: 7774 LYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPS------ETCPSEGCP-----GLQ 7920
            +Y FSI+GFL+ + DF LEVD + N+ S     G+P       +TC  +         +
Sbjct: 2380 VYLFSIVGFLFLKDDFILEVDRLPNNHSTASPLGMPHGAAAFVDTCSGDKMDCVSGLSVP 2439

Query: 7921 PSXXXXXXXXXXXXSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMT 8100
                          +C+TL MCI+     GLRNGGG+GD+LR P+  E +F  RV YD+
Sbjct: 2440 EVLEEDRELDSTERACDTLLMCIVTVMNHGLRNGGGVGDILRKPSKDESLFPARVVYDLL 2499

Query: 8101 XXXXXXXXXXXXXXXXXXDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHR 8280
                              DTF DLR+EK +KE+ILK  CFICGL+R +FDN++V+FE H
Sbjct: 2500 FFFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHI 2559

Query: 8281 ETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQ 8460
            + EHN+W+YLY+IV++++K++T++TGPESYVAQ +K++NLDWFPRM+A+SL  +E + +Q
Sbjct: 2560 KLEHNMWNYLYFIVLVRVKNKTDYTGPESYVAQMIKNKNLDWFPRMRAMSLVSNEGEGEQ 2619

Query: 8461 SEVKQMKDQLLQMMTLMREIISQNEESRAFMEQFQPR 8571
            +E++ ++D+L   M L+  + +Q  E +  M + + R
Sbjct: 2620 NEIRILQDKLNSTMKLVSHLTAQLNELKEQMTEQRKR 2656


>gi|17366458|sp|Q14573|IP3T_HUMAN Inositol 1,4,5-trisphosphate
            receptor type 3 (Type 3 inositol 1,4,5-trisphosphate
            receptor) (Type 3 InsP3 receptor) (IP3 receptor isoform
            3) (InsP3R3)
 gi|483831|dbj|BAA05385.1| type 3 inositol 1,4,5-trisphosphate
            receptor [Homo sapiens]
          Length = 2671

 Score = 1581 bits (4093), Expect = 0.0
 Identities = 1049/2915 (35%), Positives = 1560/2915 (52%), Gaps = 94/2915 (3%)
 Frame = +1

Query: 109  LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
            LHIGDI+SLY E S N    GF+STLGLVDDRC+VE   G  ++PPKKFRDCLFKVCP+N
Sbjct: 8    LHIGDIVSLYAEGSVN----GFISTLGLVDDRCVVEPAAGDLDNPPKKFRDCLFKVCPMN 63

Query: 289  RYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQ 468
            RY+AQK  W  ++  Q  + + D  L+ KL+ AA  E+++N++E +K  G+V++YGS++Q
Sbjct: 64   RYSAQKQYWKAKQTKQDKEKIADVVLLQKLQHAAQMEQKQNDTENKKVHGDVVKYGSVIQ 123

Query: 469  LLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKI 648
            LLH+KSNKY+TV K  PA  E+NAM+V LD  GNEGSW  I+P +K  + GDNV  G+K+
Sbjct: 124  LLHMKSNKYLTVNKRLPALLEKNAMRVTLDATGNEGSWLFIQPFWKLRSNGDNVVVGDKV 183

Query: 649  SLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSV 828
             L P       AG     LH S++ L D+    EVN +N  T W++ +F+ F ++ +  +
Sbjct: 184  ILNP-----VNAGQ---PLHASNYELSDNAGCKEVNSVNCNTSWKINLFMQFRDHLEEVL 235

Query: 829  KSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTN 1008
            K GDVVRLFHA+Q+ FLT D    +      VFLR T R SA  ATSS ALWEV+VV  +
Sbjct: 236  KGGDVVRLFHAEQEKFLTCDEYKGKLQ----VFLRTTLRQSATSATSSNALWEVEVVHHD 291

Query: 1009 AYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRPPLLSALSQKSRPMLERTNN 1188
              RGG   WN  YRFKHLAT  YL+AE +     P+  G                   ++
Sbjct: 292  PCRGGAGHWNGLYRFKHLATGNYLAAEEN-----PSYKGD-----------------ASD 329

Query: 1189 PMA--MYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNK 1362
            P A  M + G  G  N       + I    V  P  ++        LF+LDP+T  K++
Sbjct: 330  PKAAGMGAQGRTGRRNAG-----EKIKYCLVAVPHGNDIAS-----LFELDPTTLQKTDS 379

Query: 1363 EVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWVKVICEKNRVDKETFALLPV 1542
             VPR SYVRL H  ++ W+ +TN      +    +     +   C   + DKE FA++ V
Sbjct: 380  FVPRNSYVRLRHLCTNTWIQSTNVP----IDIEEERPIRLMLGTCP-TKEDKEAFAIVSV 434

Query: 1543 NPDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADP 1722
               E+RDLDFANDA   L + ++ +  G  IS+       QLL D + FV++  ++  +
Sbjct: 435  PVSEIRDLDFANDASSMLASAVEKLNEG-FISQNDRRFVIQLLEDLVFFVSDVPNNGQNV 493

Query: 1723 LKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIF 1902
            L I    P+R+RQKL+REQ +L QVF +LKAPF  + G               D +N  +
Sbjct: 494  LDIMVTKPNRERQKLMREQNILKQVFGILKAPFREKGGE----GPLVRLEELSDQKNAPY 549

Query: 1903 KTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKY 2082
            + MF+LCY +L++SQ  YRKNQE +A++FG +Q QIG+D++AEDT+TA+LHNN KLLEK+
Sbjct: 550  QHMFRLCYRVLRHSQEDYRKNQEHIAKQFGMMQSQIGYDILAEDTITALLHNNRKLLEKH 609

Query: 2083 VKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTK 2262
            +    VE FV LVR NR+ +FLDYL+DLCV    A    QELIC  VL  K+ DI + T+
Sbjct: 610  ITKTEVETFVSLVRKNREPRFLDYLSDLCVSNHIAIPVTQELICKCVLDPKNSDILIRTE 669

Query: 2263 I-----------------IDGEIEVGWAP-----NFRKLVDIAEGAKS-NSDDAEHLDYY 2373
            +                  + E+ + W       + + +  +A+ A++ N+ D   L YY
Sbjct: 670  LRPVKEMAQSHEYLSIEYSEEEVWLTWTDKNNEHHEKSVRQLAQEARAGNAHDENVLSYY 729

Query: 2374 RHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLM 2553
            R+QL L ++MC ++QYLAID         ISQQL  +L+  CM+D  LP+DLR SF  LM
Sbjct: 730  RYQLKLFARMCLDRQYLAID--------EISQQLGVDLIFLCMADEMLPFDLRASFCHLM 781

Query: 2554 LHLHVVRGSP--MSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLA 2727
            LH+HV R     ++ ++ ARLW  IP  + +  Y+S ++ A  D  + +         +
Sbjct: 782  LHVHVDRDPQELVTPVKFARLWTEIPTAITIKDYDS-NLNASRDDKKNKFA-----NTME 835

Query: 2728 TVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIIN- 2904
             VE YL  + ++++        +KLT+E+V+LA  L  F FYSF++LL+LT+ LL II+
Sbjct: 836  FVEDYLNNVVSEAVPFANE-EKNKLTFEVVSLAHNLIYFGFYSFSELLRLTRTLLGIIDC 894

Query: 2905 -EGPATEQVPSHRAMVNAI-----RNMSKSMMRGGNKENSKDLAKTPSV----------- 3033
             +GP         AM+ A      +N+ +S+   G+  ++  L++  SV
Sbjct: 895  VQGPP--------AMLQAYEDPGGKNVRRSIQGVGHMMSTMVLSRKQSVFSAPSLSAGAS 946

Query: 3034 TAEEAGRTK--EGRALNV-KTKLIVAEILQFVMDVRRDYRITMALSWFK----NVFPCDE 3192
             AE   R+K  E   + V +TKL + EILQF+++VR DYRI+  LS FK     VFP  +
Sbjct: 947  AAEPLDRSKFEENEDIVVMETKLKILEILQFILNVRLDYRISHLLSVFKKEFVEVFPMQD 1006

Query: 3193 DGS-------LMHSASINERMASELYDAIY--RSSGHELHLDGRDGQLLLAILLQMTMSD 3345
             G+          +A++N     E  +A++    +   L +D   G++ L +L+ +TM D
Sbjct: 1007 SGADGTAPAFDSTTANMNLDRIGEQAEAMFGVGKTSSMLEVDDEGGRMFLRVLIHLTMHD 1066

Query: 3346 YPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSEL 3525
            Y PL S AL++ F+HF+Q QE +   KQVQLL+S  DVENY+ I  +L  L+ + EKSEL
Sbjct: 1067 YAPLVSGALQLLFKHFSQRQEAMHTFKQVQLLISAQDVENYKVIKSELDRLRTMVEKSEL 1126

Query: 3526 WVHGDRHHSIDTKEV------DEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHY 3687
            WV  D+  S   +EV      D+KER T+ +   H    P    S ++ + +  +L
Sbjct: 1127 WV--DKKGSGKGEEVEAGAAKDKKERPTDEEGFLH----PPGEKSSENYQIVKGILE--- 1177

Query: 3688 PSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDPK 3867
                                                           RL  MC   G  +
Sbjct: 1178 -----------------------------------------------RLNKMC---GVGE 1187

Query: 3868 PDTMNQQ-LLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRL 4044
                 QQ LLKNM  ++V+L+ + +P+D K D  MM+++  +H+FL+ FC  N  NQ+ L
Sbjct: 1188 QMRKKQQRLLKNMDAHKVMLDLLQIPYD-KGDAKMMEILRYTHQFLQKFCAGNPGNQALL 1246

Query: 4045 YKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPI 4224
            +K +        G+L  ET++       IF NN +L S + E ++ H V L+  + R+
Sbjct: 1247 HKHL--HLFLTPGLLEAETMQH------IFLNNYQLCSEISEPVLQHFVHLLATHGRHVQ 1298

Query: 4225 FLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGR 4404
            +L+ L  ++    K ++  Q+ +  E+  A D+V   Y D AS   L  MMK  ++
Sbjct: 1299 YLDFLHTVIKAEGKYVKKCQDMIMTELTNAGDDVVVFYNDKASLAHLLDMMKAARD---- 1354

Query: 4405 SSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYL 4584
              +    L YHI LV LLA C  GKN  TE+KC S +P++ +V VVT + C+ EVK  Y+
Sbjct: 1355 GVEDHSPLMYHISLVDLLAACAEGKNVYTEIKCTSLLPLEDVVSVVTHEDCITEVKMAYV 1414

Query: 4585 QLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEKLTGAETATLEHYICHTVTE 4764
              + HCY+DT+ EMK+ Y + ++  +  N   D+  +  ++       TLE Y+   V +
Sbjct: 1415 NFVNHCYVDTEVEMKEIYTSNHIWTLFENFTLDMARVCSKREKRVADPTLEKYVLSVVLD 1474

Query: 4765 VLIKFFEAPYS----ALQQAKVDVHHHKKTFSEVLLELTYLEKGKLRGSKSSRNWYRVAE 4932
             +  FF +P+S    +LQ  +  V    ++ +  LLE  +L++ + +GS        V
Sbjct: 1475 TINAFFSSPFSENSTSLQTHQTIVVQLLQSTTR-LLECPWLQQ-QHKGS--------VEA 1524

Query: 4933 CIKRLTKWAEEHNITLPATL---AGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTL 5103
            CI+ L   A+   I LP  L       +S   S     Q+ ASS K            T
Sbjct: 1525 CIRTLAMVAKGRAILLPMDLDAHISSMLSSGASCAAAAQRNASSYK-----------ATT 1573

Query: 5104 NPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPE 5283
                R+  T+N   +    N++     +I   +  L PL  AE SVLV+VLH PELLF E
Sbjct: 1574 RAFPRVTPTAN---QWDYKNIIEKLQDIITALEERLKPLVQAELSVLVDVLHWPELLFLE 1630

Query: 5284 GSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKQQLTHQGHRVYN 5463
            GS    +C  GG ++KLIQH K LM++ ++ LC +VL+TL +M    K +   +G+++
Sbjct: 1631 GSEAYQRCESGGFLSKLIQHTKDLMES-EEKLCIKVLRTLQQML-LKKTKYGDRGNQLRK 1688

Query: 5464 SSVEKGXXXXXXXXXXYFGHHNNHHPPLDRQQSXXXXXXXXXXXXXXXTWSQERDLYAIQ 5643
              ++                        +R+ +                WS    + A Q
Sbjct: 1689 MLLQNYLQ--------------------NRKSTSRGDLPDPIGTGLDPDWSA---IAATQ 1725

Query: 5644 CKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEPF 5823
            C+L+  GA+ LV D+I    + +IF ++I LA  LL  GN ++Q SF+  M      E F
Sbjct: 1726 CRLDKEGATKLVCDLITSTKNEKIFQESIGLAIHLLDGGNTEIQKSFHNLMMSDKKSERF 1785

Query: 5824 FKAILTRIQTAQNRLKSDM---MSCSDSKPKVSSTVLTPLIDAGDTGFNGALFEVPQQVR 5994
            FK +  R++ AQ   KS +   M+   S+P      + P      T    A F +P
Sbjct: 1786 FKVLHDRMKRAQQETKSTVAVNMNDLGSQPHEDREPVDP-----TTKGRVASFSIPGSSS 1840

Query: 5995 HPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPEVALVEPILRVLQLLCENHNSLLQ 6174
              S+    +  ++++  +      Q  E  T  L     +++PILR LQLLCENHN  LQ
Sbjct: 1841 RYSLGPSLRRGHEVSERV------QSSEMGTSVL-----IMQPILRFLQLLCENHNRDLQ 1889

Query: 6175 NFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFG-EIGEHNFSLITQTLATLTEFCQ 6351
            NFLR Q+++TN+NLV ETL FLD +CGST G LG+ G  I E N  L+ QTL TLTE+CQ
Sbjct: 1890 NFLRCQNNKTNYNLVCETLQFLDIMCGSTTGGLGLLGLYINEDNVGLVIQTLETLTEYCQ 1949

Query: 6352 GPCHENQNTMAMQE-NGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIMESRHD 6528
            GPCHENQ  +   E NG++II +L+LN+I PL    M+L L++K  ASKLLLA+MESRHD
Sbjct: 1950 GPCHENQTCIVTHESNGIDIITALILNDISPLCKYRMDLVLQLKDNASKLLLALMESRHD 2009

Query: 6529 GENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLKKKSGP 6708
             ENA R+L     +S  P++LV  IK+AY                   Q E+    +  P
Sbjct: 2010 SENAERIL-----ISLRPQELVDVIKKAY------------------LQEEERENSEVSP 2046

Query: 6709 QITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNIYILAHQL 6888
            +   + + +  + +        H  K +    +++                    ++  L
Sbjct: 2047 REVGHNIYILALQLSRHNKQLQHLLKPVKRIQEEEAEG-----------------ISSML 2089

Query: 6889 AIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPINDICSYLT 7068
            ++++ +L   L  S   +++   + L YY+  T+QIEIVR+DR++E++VFP+  IC +LT
Sbjct: 2090 SLNNKQLSQMLKSSAPAQEE-EEDPLAYYENHTSQIEIVRQDRSMEQIVFPVPGICQFLT 2148

Query: 7069 KDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPLWTRLS 7248
            ++TK  ++  TE+D QGSKV++FFD+   +++EM WQR ++    + W + R+ LW  +S
Sbjct: 2149 EETKHRLFTTTEQDEQGSKVSDFFDQSSFLHNEMEWQRNVRSMPLIYWFSRRMTLWGSIS 2208

Query: 7249 FHFAFIVNALVARYYPLPEHSNSSI---SLGNLYSWFAVFSSFLLAHYLRHDKIYLHKTX 7419
            F+ A  +N ++A +YP  E +++ +    L +L  W  +  S       R+       +
Sbjct: 2209 FNLAVFINIIIAFFYPYMEGASTGVLDSPLISLLFWILICFSIAALFTKRY-------SI 2261

Query: 7420 XXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRNLH 7599
                          +G+  TL I G L L NKIV VV+FV N+G   R    ++
Sbjct: 2262 RPLIVALILRSIYYLGIGPTLNILGALNLTNKIVFVVSFVGNRGTFIRGYKAMVMDMEFL 2321

Query: 7600 YLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALILLY 7779
            Y + Y+   +LGL  H + Y ILLFD+I+ EETL NVI SVTRN +SI+ T LLALIL+Y
Sbjct: 2322 YHVGYILTSVLGLFAHELFYSILLFDLIYREETLFNVIKSVTRNGRSILLTALLALILVY 2381

Query: 7780 FFSILGFLYFRHDFYLEVDPVENDSSATISSGIPS------ETCPSEGCP-----GLQPS 7926
             FSI+GFL+ + DF LEVD + N+ S     G+P       +TC  +         +
Sbjct: 2382 LFSIVGFLFLKDDFILEVDRLPNNHSTASPLGMPHGAAAFVDTCSGDKMDCVSGVSVPEV 2441

Query: 7927 XXXXXXXXXXXXSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTXX 8106
                        +C+TL MCI+     GLRNGGG+GD+LR P+  E +F  RV YD+
Sbjct: 2442 LEEDRELDSTERACDTLLMCIVTVMNHGLRNGGGVGDILRKPSKDESLFPARVVYDLLFF 2501

Query: 8107 XXXXXXXXXXXXXXXXDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRET 8286
                            DTF DLR+EK +KE+ILK  CFICGL+R +FDN++V+FE H +
Sbjct: 2502 FIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKL 2561

Query: 8287 EHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSE 8466
            EHN+W+YLY+IV++++K++T++TGPESYVAQ +K++NLDWFPRM+A+SL  +E + +Q+E
Sbjct: 2562 EHNMWNYLYFIVLVRVKNKTDYTGPESYVAQMIKNKNLDWFPRMRAMSLVSNEGEGEQNE 2621

Query: 8467 VKQMKDQLLQMMTLMREIISQNEESRAFMEQFQPR 8571
            ++ ++D+L   M L+  + +Q  E +  M + + R
Sbjct: 2622 IRILQDKLNSTMKLVSHLTAQLNELKEQMTEQRKR 2656


>gi|6981110|ref|NP_037270.1| inositol 1, 4, 5-triphosphate receptor 3
            [Rattus norvegicus]
 gi|17365979|sp|Q63269|IP3T_RAT Inositol 1,4,5-trisphosphate receptor
            type 3 (Type 3 inositol 1,4,5-trisphosphate receptor)
            (Type 3 InsP3 receptor) (IP3 receptor isoform 3)
            (InsP3R3) (IP3R-3)
 gi|423895|pir||A46719 inositol 1,4,5-trisphosphate receptor subtype 3
            - rat
 gi|310171|gb|AAA41446.1| inositol triphosphate receptor subtype 3
          Length = 2670

 Score = 1575 bits (4079), Expect = 0.0
 Identities = 1039/2911 (35%), Positives = 1557/2911 (52%), Gaps = 90/2911 (3%)
 Frame = +1

Query: 109  LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
            LHIGDI+SLY E S N    GF+STLGLVDDRC+VE   G  ++PPKKFRDCLFKVCP+N
Sbjct: 8    LHIGDIVSLYAEGSVN----GFISTLGLVDDRCVVEPAAGDLDNPPKKFRDCLFKVCPMN 63

Query: 289  RYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQ 468
            RY+AQK  W  ++  Q  + + D  L+ KL+ AA  E+++N++E +K  G+V++YGS++Q
Sbjct: 64   RYSAQKQYWKAKQTKQDKEKIADVVLLQKLQHAAQMEQKQNDTENKKVHGDVVKYGSVIQ 123

Query: 469  LLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKI 648
            LLH+KSNKY+TV K  PA  E+NAM+V LD  GNEGSW  I+P +K  + GDNV  G+K+
Sbjct: 124  LLHMKSNKYLTVNKRLPALLEKNAMRVTLDATGNEGSWLFIQPFWKLRSNGDNVVVGDKV 183

Query: 649  SLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSV 828
             L P       AG     LH S++ L D+    EVN +N  T W++ +F+ F ++ +  +
Sbjct: 184  ILNP-----VNAGQ---PLHASNYELSDNVGCKEVNSVNCNTSWKINLFMQFRDHLEEVL 235

Query: 829  KSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTN 1008
            K GDVVRLFHA+Q+ FLT D    +      VFLR T R SA  ATSS ALWEV+VV  +
Sbjct: 236  KGGDVVRLFHAEQEKFLTCDEYRGKLQ----VFLRTTLRQSATSATSSNALWEVEVVHHD 291

Query: 1009 AYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRPPLLSALSQKSRPMLERTNN 1188
              RGG   WN  YRFKHLAT  YL+AE +     P+  G                   ++
Sbjct: 292  PCRGGAGHWNGLYRFKHLATGNYLAAEEN-----PSYKGD-----------------VSD 329

Query: 1189 PMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEV 1368
            P A    GP   +        + I    V  P  ++        LF+LDP+T  K++  V
Sbjct: 330  PKAA---GPGAQSRTGRRNAGEKIKYRLVAVPHGNDIAS-----LFELDPTTLQKTDSFV 381

Query: 1369 PRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWVKVICEKNRVDKETFALLPVNP 1548
            PR SYVRL H  ++ W+ +TNA     +    +     +   C   + DKE FA++ V
Sbjct: 382  PRNSYVRLRHLCTNTWIQSTNAP----IDVEEERPIRLMLGTCP-TKEDKEAFAIVSVPV 436

Query: 1549 DEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADPLK 1728
             E+RDLDFANDA   L + ++ +  G  IS+       QLL D + FV++  ++  + L
Sbjct: 437  SEIRDLDFANDASSMLASAVEKLNEG-FISQNDRRFVIQLLEDLVFFVSDVPNNGQNVLD 495

Query: 1729 ISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIFKT 1908
            I    P+R+RQKL+R++ +L Q+F +LKAPF  + G               D +N  ++
Sbjct: 496  IMVTKPNRERQKLMRDENILKQIFGILKAPFRDKGGE----GPLVRLEELSDQKNAPYQY 551

Query: 1909 MFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVK 2088
            MF+LCY +L++SQ  YRKNQE +A++FG +Q QIG+D++AEDT+TA+LHNN KLLEK++
Sbjct: 552  MFRLCYRVLRHSQEDYRKNQEHIAKQFGMMQSQIGYDILAEDTITALLHNNRKLLEKHIT 611

Query: 2089 TPHVERFVELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKI- 2265
               VE FV LVR NR+ +FLDYL+DLCV    A    QELIC  VL  K+ DI + T++
Sbjct: 612  KTEVETFVSLVRKNREPRFLDYLSDLCVSNRIAIPVTQELICKCVLDPKNSDILIQTELR 671

Query: 2266 ----------------IDGEIEVGWAP-----NFRKLVDIAEGAKS-NSDDAEHLDYYRH 2379
                             + E+ + W       + + +  +A+ A++ N+ D   L YYR+
Sbjct: 672  PVKEMAQSHEYLSIEYSEEEVWLTWTDRNNEHHEKSVRQLAQEARAGNAHDENVLSYYRY 731

Query: 2380 QLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLH 2559
            QL L ++MC ++QYLAID         IS+QL  EL+  CM+D  LP+DLR SF  LMLH
Sbjct: 732  QLKLFARMCLDRQYLAID--------EISKQLGVELLFLCMADEMLPFDLRASFCHLMLH 783

Query: 2560 LHVVRGSP--MSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATV 2733
            +HV R     ++ ++ ARLW  IP  + +  Y+S ++ A  D  +        +K  +T+
Sbjct: 784  VHVDRDPQELVTPVKFARLWTEIPTAITIKDYDS-NLNASRDDKK--------NKFASTM 834

Query: 2734 ETYLMGLRNQSMEERQSVNSSK--LTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINE 2907
            E     L N   E     N  K  LT+E+V+LA  L  F FYSF++LL+LT+ LL II
Sbjct: 835  EFVEDYLNNVVGEAVPFANDEKNILTFEVVSLAHNLIYFGFYSFSELLRLTRTLLGII-- 892

Query: 2908 GPATEQVPSHRAMVNAI-----RNMSKSMMRGGNKENSKDLAKTPSV-----------TA 3039
                + + +  A++ A      +N+ +S+   G+  ++  L++  SV
Sbjct: 893  ----DCIQAPAAVLQAYEEPGGKNVRRSIQGVGHMMSTMVLSRKQSVFGASSLPTGVGVP 948

Query: 3040 EEAGRTK---EGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFK----NVFPCDEDG 3198
            E+  R+K       + ++TKL + EILQF+++VR DYRI+  LS FK     VFP  + G
Sbjct: 949  EQLDRSKFEDNEHTVVMETKLKILEILQFILNVRLDYRISYLLSVFKKEFVEVFPMQDSG 1008

Query: 3199 S-------LMHSASINERMASELYDAIY--RSSGHELHLDGRDGQLLLAILLQMTMSDYP 3351
            +          +A++N     E  +A++    +   L +D   G++ L +LL +TM DYP
Sbjct: 1009 ADGTAPAFDSSTANMNLDRIGEQAEAMFGVGKTSSMLEVDDEGGRMFLRVLLHLTMHDYP 1068

Query: 3352 PLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWV 3531
            PL S AL++ F+HF+Q QE +   KQVQLL+S  DVENY+ I  +L  L+ + EKSELWV
Sbjct: 1069 PLVSGALQLLFKHFSQRQEAMHTFKQVQLLISAQDVENYKVIKSELDRLRTMVEKSELWV 1128

Query: 3532 HGDRHHSIDTKE------VDEKERTTEHD--LLDHDLKSPRAFDSGDSMEALMAVLNEHY 3687
              D+  S+  +E       D+KER ++ +  L  H  KS                 +E+Y
Sbjct: 1129 --DKKGSVKGEEGEAGASKDKKERPSDEEGFLQPHGEKS-----------------SENY 1169

Query: 3688 PSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDPK 3867
              ++                                        +L RL  MC      +
Sbjct: 1170 QIVKG---------------------------------------ILERLNKMC--GVGEQ 1188

Query: 3868 PDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLY 4047
                 Q+LLKNM  ++V+L+ + +P+D K+D+ MM+++  +H+FL+ FC  N  NQ+ L+
Sbjct: 1189 MRKKQQRLLKNMDAHKVMLDLLQIPYD-KNDNKMMEILRYTHQFLQKFCAGNPGNQALLH 1247

Query: 4048 KFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIF 4227
            K +  +     G+L  ET++       IF NN +L S + E ++ H V     + R+  +
Sbjct: 1248 KHL--QLFLTPGLLEAETMQH------IFLNNYQLCSEISEPVLQHFVHCWPTHGRHVQY 1299

Query: 4228 LELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRS 4407
            L+ L  ++    K ++  Q+ +  E+  A D+V   Y D AS   L  MMK  ++
Sbjct: 1300 LDFLHTVIKAEGKYVKKCQDMIMTELTNAGDDVVVFYNDKASLAHLLDMMKAARD----G 1355

Query: 4408 SDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQ 4587
             +    L YHI LV LLA C  GKN  TE+KC S +P++ +V VVT + C+ EVK  Y+
Sbjct: 1356 VEDHSPLMYHISLVDLLAACAEGKNVYTEIKCTSLLPLEDVVSVVTHEDCITEVKMAYVN 1415

Query: 4588 LLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEKLTGAETATLEHYICHTVTEV 4767
             + HCY+DT+ EMK+ Y + ++  +  N   D+  +  ++       TLE Y+   V +
Sbjct: 1416 FVNHCYVDTEVEMKEIYTSNHIWTLFENFTLDMALVCNKREKRLSDPTLEKYVLTVVLDT 1475

Query: 4768 LIKFFEAPYS----ALQQAKVDVHHHKKTFSEVLLELTYLEKGKLRGSKSSRNWYRVAEC 4935
            +  FF +P+S    +LQ  +  V    ++ +  LLE  +L++ + +GS        V  C
Sbjct: 1476 ISAFFSSPFSENSTSLQTHQTIVVQLLQSTTR-LLECPWLQQ-QHKGS--------VEAC 1525

Query: 4936 IKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGH 5115
            ++ L   A+   I LP  L    MS   S       AA  +         N +
Sbjct: 1526 VRTLAMVAKSRAILLPMDL-DAHMSALLSSGGSCSAAAQRS-------AANYKTATRTFP 1577

Query: 5116 RLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSAL 5295
            R+  T+N   +    N++     +I   +  L PL  AE SVLV++LH PELLF EGS
Sbjct: 1578 RVIPTAN---QWDYKNIIEKLQDIITALEERLKPLVQAELSVLVDMLHWPELLFLEGSEA 1634

Query: 5296 RDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKQQLTHQGHRVYNSSVE 5475
              +C  GG ++KLI+H K LM++ ++ LC +VL+TL +M    K +   +G+++    ++
Sbjct: 1635 YQRCESGGFLSKLIRHTKGLMES-EEKLCVKVLRTLQQMLQ-KKSKYGDRGNQLRKMLLQ 1692

Query: 5476 KGXXXXXXXXXXYFGHHNNHHPPLDRQQSXXXXXXXXXXXXXXXTWSQERDLYAIQCKLN 5655
                                    +R+                  WS    + A QC+L+
Sbjct: 1693 NYLQ--------------------NRKSGPRGELTDPTGSGVDQDWSA---IAATQCRLD 1729

Query: 5656 DAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEPFFKAI 5835
              GA+ LV D+I    + +IF ++I LA  LL  GN ++Q SFY  M      E FFK +
Sbjct: 1730 KEGATKLVCDLITSTKNEKIFQESIGLAIRLLDGGNTEIQKSFYNLMTSDKKSERFFKVL 1789

Query: 5836 LTRIQTAQNRLKSDM---MSCSDSKPKVSSTVLTPLIDAGDTGFNGALFEVPQQVRHPSI 6006
              R++ AQ   KS +   MS   S+P+       P      T    + F +P   R+ S+
Sbjct: 1790 HDRMKRAQQETKSTVAVNMSDLGSQPREDREPADP-----TTKGRVSSFSMPSSSRY-SL 1843

Query: 6007 SEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPEVALVEPILRVLQLLCENHNSLLQNFLR 6186
                   +D++           E    + +   V ++ PILR LQLLCENHN  LQNFLR
Sbjct: 1844 GPGLHRGHDVS-----------ERAQNNEMGTSVLIMRPILRFLQLLCENHNRDLQNFLR 1892

Query: 6187 KQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFG-EIGEHNFSLITQTLATLTEFCQGPCH 6363
             Q+++TN+NLV ETL FLD +CGST G LG+ G  I E N  L+ QTL TLTE+CQGPCH
Sbjct: 1893 CQNNKTNYNLVCETLQFLDIMCGSTTGGLGLLGLYINEDNVGLVIQTLETLTEYCQGPCH 1952

Query: 6364 ENQNTMAMQE-NGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIMESRHDGENA 6540
            ENQ  +   E NG++II +L+LN+I PL    M+L L++K  ASKLLLA+MESRHD ENA
Sbjct: 1953 ENQTCIVTHESNGIDIITALILNDISPLCKYRMDLVLQLKDNASKLLLALMESRHDSENA 2012

Query: 6541 NRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLKKKSGPQITV 6720
             R+L     +S  P++LV  IK+AY                   Q E+    +  P+
Sbjct: 2013 ERIL-----ISLRPQELVDVIKKAY------------------LQEEERENSEVSPREVG 2049

Query: 6721 NTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNIYILAHQLAIHD 6900
            + + +  + +        H  K +    +++                    ++  L++++
Sbjct: 2050 HNIYILALQLSRHNKQLQHLLKPVKRIQEEEAEG-----------------ISSMLSLNN 2092

Query: 6901 GELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPINDICSYLTKDTK 7080
             +L   L  S   +++   + L YY+  T+QIEIVR+DR++E++VFP+  IC +LT++TK
Sbjct: 2093 KQLSQMLKSSAPAQEE-EEDPLAYYENHTSQIEIVRQDRSMEQIVFPVPAICQFLTEETK 2151

Query: 7081 DYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPLWTRLSFHFA 7260
              ++  TE+D QGSKV++FFD+   +++EM WQR+L+    + W + R+ LW  +SF+ A
Sbjct: 2152 HRLFTTTEQDEQGSKVSDFFDQSSFLHNEMEWQRRLRSMPLIYWFSRRMTLWGSISFNLA 2211

Query: 7261 FIVNALVARYYPLPEHSNSSI---SLGNLYSWFAVFSSFLLAHYLRHDKIYLHKTXXXXX 7431
              +N ++A +YP  E +++ +    L +L  W  +  S + A + +H  +
Sbjct: 2212 VFINIIIAFFYPYVEGASTGVLGSPLISLLFWILICFS-IAALFTKHYSV------RPLI 2264

Query: 7432 XXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRNLHYLLV 7611
                      +G+  TL I G L L NKIV VV+FV N+G   R    ++      Y +
Sbjct: 2265 VALVLRSIYYLGIGPTLNILGALNLTNKIVFVVSFVGNRGTFIRGYKAMVMDMEFLYHVG 2324

Query: 7612 YLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALILLYFFSI 7791
            Y+   +LGL  H + Y ILLFD+I+ EETL NVI SVTRN +SI+ T LLALIL+Y FSI
Sbjct: 2325 YILTSVLGLFAHELFYSILLFDLIYREETLFNVIKSVTRNGRSILLTALLALILVYLFSI 2384

Query: 7792 LGFLYFRHDFYLEVDPVENDSSATISSGIPSETCPSEG-CPG----------LQPSXXXX 7938
            +GFL+ + DF LEVD +  + S   + G+P       G C G          +
Sbjct: 2385 VGFLFLKDDFILEVDRLPGNHSRASTLGMPHGAATFMGTCSGDKMDCVSEVSVPEILEED 2444

Query: 7939 XXXXXXXXSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTXXXXXX 8118
                    +C+TL MCI+     GLRNGGG+GD+LR P+  E +F  RV YD+
Sbjct: 2445 EELDSTERACDTLLMCIVTVMNHGLRNGGGVGDILRKPSKDESLFPARVVYDLLFFFIVI 2504

Query: 8119 XXXXXXXXXXXXDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNI 8298
                        DTF DLR+EK +KE+ILK  CFICGL+R +FDN++V+FE H + EHN+
Sbjct: 2505 IIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKLEHNM 2564

Query: 8299 WHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQM 8478
            W+YLY+IV++++K++T++TGPESYVAQ +K++NLDWFPRM+A+SL   E + +Q+E++ +
Sbjct: 2565 WNYLYFIVLVRVKNKTDYTGPESYVAQMIKNKNLDWFPRMRAMSLVSGEGEGEQNEIRIL 2624

Query: 8479 KDQLLQMMTLMREIISQNEESRAFMEQFQPR 8571
            +++L   M L+  + +Q  E +  M + + R
Sbjct: 2625 QEKLGSTMKLVSHLTAQLNELKEQMTEQRKR 2655


>gi|27805963|ref|NP_776795.1| inositol 1,4,5-triphosphate receptor,
            type 3 [Bos taurus]
 gi|17432548|gb|AAL39078.1| inositol 1,4,5-trisphosphate receptor type
            3 [Bos taurus]
          Length = 2664

 Score = 1570 bits (4065), Expect = 0.0
 Identities = 1044/2908 (35%), Positives = 1542/2908 (52%), Gaps = 87/2908 (2%)
 Frame = +1

Query: 109  LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
            LHIGDI+SLY E S N    GF+STLGLVDDRC+VE   G  ++PPKKFRDCLFKVCP+N
Sbjct: 8    LHIGDIVSLYAEGSVN----GFISTLGLVDDRCVVEPAAGDLDNPPKKFRDCLFKVCPMN 63

Query: 289  RYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQ 468
            RY+AQK  W  ++  Q  + + D  L+ KL+ AA  E+++N++E +K  G+V++YGS++Q
Sbjct: 64   RYSAQKQYWKAKQTKQDKEKIADVVLLQKLQHAAQMEQKQNDTENKKVHGDVVKYGSVIQ 123

Query: 469  LLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKI 648
            LLH+KSNKY+TV K  PA  E+NAM+V LD  GNEGSW  I+P +K  + GDNV  G+K+
Sbjct: 124  LLHMKSNKYLTVNKRLPALLEKNAMRVTLDATGNEGSWLFIQPFWKLRSNGDNVVVGDKV 183

Query: 649  SLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSV 828
             L P       AG     LH S++ L D+    EVN +N  T W++ +F+ F ++ +  +
Sbjct: 184  ILNP-----VNAGQ---PLHASNYELSDNAGCKEVNSVNCNTSWKINLFMQFRDHLEEVL 235

Query: 829  KSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTN 1008
            K GDVVRLFHA+Q+ FLT D    +      VFLR T R SA  ATSS ALWEV+VV  +
Sbjct: 236  KGGDVVRLFHAEQEKFLTCDEYRGKLQ----VFLRTTLRQSATSATSSNALWEVEVVHHD 291

Query: 1009 AYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRPPLLSALSQKSRPMLERTNN 1188
              RGG   WN  YRFKHLAT  YL+AE +     P+  G           S P    T
Sbjct: 292  PCRGGAGHWNGLYRFKHLATGNYLAAEEN-----PSYKG---------DASDPKAAGTG- 336

Query: 1189 PMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEV 1368
                 + G  G  N       + I    V  P  ++        LF+LDP+T  K++  V
Sbjct: 337  -----AQGRTGRRNAG-----EKIKYRLVAVPHGNDIAS-----LFELDPTTLQKTDSFV 381

Query: 1369 PRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWVKVICEKNRVDKETFALLPVNP 1548
            PR SYVRL H  ++ W+ +TN      +    +     +   C   + DKE FA++ V
Sbjct: 382  PRNSYVRLRHLCTNTWIQSTNVP----IDVEEERPIRLMLGTCP-TKEDKEAFAIVSVPV 436

Query: 1549 DEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADPLK 1728
             E+RDLDFANDA   L + ++ +  G  IS+       QLL D + FV++  ++  + L
Sbjct: 437  SEIRDLDFANDASSMLASAVEKLHEG-FISQNDRRFVIQLLEDLVFFVSDVPNNGQNVLD 495

Query: 1729 ISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIFKT 1908
            I    P+R+RQKL+REQ +L Q+F +LKAPF  + G               D +N  ++
Sbjct: 496  IMVTKPNRERQKLMREQNILKQIFGILKAPFRDKGGE----GPLVRLEELSDQKNAPYQH 551

Query: 1909 MFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVK 2088
            MF+LCY +L++SQ  YRKNQE +A++FG +Q QIG+D++AEDT+TA+LHNN KLLEK++
Sbjct: 552  MFRLCYRVLRHSQEDYRKNQEHIAKQFGMMQSQIGYDILAEDTITALLHNNRKLLEKHIT 611

Query: 2089 TPHVERFVELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKI- 2265
               VE FV LVR NR+ +FLDYL+DLCV    A    QELIC  VL  K+ DI + T++
Sbjct: 612  KTEVETFVSLVRKNREPRFLDYLSDLCVSNHIAIPVTQELICKCVLDPKNSDILIQTELR 671

Query: 2266 ----------------IDGEIEVGWAP-----NFRKLVDIAEGAKS-NSDDAEHLDYYRH 2379
                             + E+ + W       + + +  +A+ A++ N+ D   L YYR+
Sbjct: 672  PVKEMAQSHEYLSIEYSEEEVWLTWTDKNNEHHEKSVRQLAQEARAGNAHDENVLSYYRY 731

Query: 2380 QLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLH 2559
            QL L ++MC ++QYLAID         ISQQL  +L+  CM+D  LP+DLR SF  LMLH
Sbjct: 732  QLKLFARMCLDRQYLAID--------EISQQLGVDLIFLCMADEMLPFDLRASFCHLMLH 783

Query: 2560 LHVVRGSP--MSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATV 2733
            +HV R     ++ ++ ARLW  IP  + +  Y+S ++ A  D  + +         +  V
Sbjct: 784  VHVDRDPQELVTPVKFARLWTEIPTAITIKDYDS-NLNASRDDKKNKFA-----STMEFV 837

Query: 2734 ETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIIN--- 2904
            E YL  + ++++        +KLT+E+V+LA  L  F FYSF++LL+LT+ LL II+
Sbjct: 838  EDYLNNVVSEAVPFANE-EKNKLTFEVVSLAHNLIYFGFYSFSELLRLTRTLLGIIDCVQ 896

Query: 2905 --EGPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAE-------EAGRT 3057
              E P  + V   R     + +M  +M+   N++ S  +   PS+ A        +  +
Sbjct: 897  AYEDPGGKNV---RRSTQGVGHMMSTMVL--NRKQS--VFGGPSLPAGAGAPEPLDGSKF 949

Query: 3058 KEGRALNV-KTKLIVAEILQFVMDVRRDYRITMALSWFK----NVFPCDEDGS------- 3201
            +E   + V +TKL + EILQF+++VR DYRI+  LS FK     VFP  + G+
Sbjct: 950  EENEDIVVMETKLKILEILQFILNVRLDYRISYLLSVFKKEFVEVFPMQDSGADGTAPAF 1009

Query: 3202 LMHSASINERMASELYDAIY--RSSGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALK 3375
               +A++N     E  +A++    +   L +D   G++LL +L+ +TM DY PL S AL+
Sbjct: 1010 DSTTANMNLDRIGEQAEAMFGVGKTSSMLEVDDEGGRMLLRVLIHLTMHDYAPLVSGALQ 1069

Query: 3376 VFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWV------HG 3537
            + F+HF+Q QE++   KQVQLL+S  DVENY+ I  +L  L+ + EKSELWV       G
Sbjct: 1070 LLFKHFSQRQEVMHTFKQVQLLISAQDVENYKVIKSELDRLRTMVEKSELWVDKKGASKG 1129

Query: 3538 DRHHSIDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQL 3717
            +   +   K  D+KER T+ +   H    P    S ++ + +  +L
Sbjct: 1130 EEGEAGPAK--DKKERPTDEEGFLH----PPGEKSSENYQIVKGILE------------- 1170

Query: 3718 LNRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDPKPDTMNQQ-LL 3894
                                                 RL  MC   G  +     QQ LL
Sbjct: 1171 -------------------------------------RLNKMC---GVGEQMRKKQQRLL 1190

Query: 3895 KNMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDA 4074
            KNM  ++V+L+ + +P+D K D  MM+++  +H+FL+ FC  N  NQ+ L+K +
Sbjct: 1191 KNMDAHKVMLDLLQIPYD-KGDAKMMEILRYTHQFLQKFCAGNPGNQALLHKHL--HLFL 1247

Query: 4075 KEGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVC 4254
              G+L  ET++       IF NN +L S + E ++ H V L+  +  +  +L+ L  ++
Sbjct: 1248 TPGLLEAETMQH------IFLNNYQLCSEIGEPVLQHFVHLLATHGHHVQYLDFLHTVIK 1301

Query: 4255 VYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKY 4434
               K ++  Q+ +  E   A D+V   Y D AS   L  MMK  ++      +    L Y
Sbjct: 1302 AEGKYVKKCQDMIMTEPANAGDDVVVFYNDKASLAHLLDMMKAARD----GVEDHSPLMY 1357

Query: 4435 HIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDT 4614
            HI LV LLA C  GKN  TE+KC S +P++ +V VVT + C+ EVK  Y+  + HCY+DT
Sbjct: 1358 HISLVDLLAACAEGKNVYTEIKCTSLLPLEDVVSVVTHEDCITEVKMAYVNFVNHCYVDT 1417

Query: 4615 DAEMKDAYKTEYVDHILNNLLEDIRSLRVEKLTGAETATLEHYICHTVTEVLIKFFEAPY 4794
            + EMK+ Y + ++  +  N   D+  +  ++        LE Y+   V + +  FF +P+
Sbjct: 1418 EVEMKEIYTSNHIWTLFENFTLDMARVCSKREKRLADPALEKYVLTVVLDTISAFFSSPF 1477

Query: 4795 SALQQAKVDVHHHKKTFSEV------LLELTYLEKGKLRGSKSSRNWYRVAECIKRLTKW 4956
            S   +    +  H+    ++      LLE  +L++ + +GS        V  CI+ L
Sbjct: 1478 S---ENSTSLQTHQTIVVQLLQSTMRLLECPWLQQ-QHKGS--------VEACIRTLAMV 1525

Query: 4957 AEEHNITLP----ATLAGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGHRLY 5124
            A+   I+LP    A ++    SG + V    + A+            N +       R+
Sbjct: 1526 AKGRAISLPMDLDAHISSLLSSGASCVAAAQRNAS------------NYKTATRAFPRVM 1573

Query: 5125 GTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQ 5304
             T+N   +    N++     +I   +  L PL  AE SVLV+VLH PELLF EGS    +
Sbjct: 1574 PTAN---QWDYKNIIEKLQDIITALEERLRPLVQAELSVLVDVLHWPELLFLEGSDAYQR 1630

Query: 5305 CARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKQQLTHQGHRVYNSSVEKGX 5484
            C  GG ++KLIQH K LM++ ++ LC +VL+TL +M    K +   +G+++    ++
Sbjct: 1631 CESGGFLSKLIQHTKDLMES-EEKLCVKVLRTLQQML-LKKTKYGDRGNQLRKMLLQNYL 1688

Query: 5485 XXXXXXXXXYFGHHNNHHPPLDRQQSXXXXXXXXXXXXXXXTWSQERDLYAIQCKLNDAG 5664
                                 +R+ S                WS    + A QC+L+  G
Sbjct: 1689 Q--------------------NRKSSSRGDLPDPMGTGLDQDWSA---IAATQCRLDKEG 1725

Query: 5665 ASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEPFFKAILTR 5844
            A+ LV D+I    + +IF ++I LA  LL  GN ++Q SFY  M      E FFK +  R
Sbjct: 1726 ATKLVCDLITSTKNEKIFQESIGLAIRLLDGGNTEIQKSFYNLMTSDKKSERFFKVLHDR 1785

Query: 5845 IQTAQNRLKSDM---MSCSDSKPKVSSTVLTPLIDAGDTGFNGALFEVPQQVRHPSISEM 6015
            ++ AQ   KS +   MS   S+P+       P        F+            PS S
Sbjct: 1786 MKRAQQETKSTVAVNMSDLGSQPREDREQADPTSKGRVASFS-----------MPSSSSR 1834

Query: 6016 SQLSNDLTHSIPDLAPYQDEEKSTDALPPEVALVEPILRVLQLLCENHNSLLQNFLRKQS 6195
              L   L          Q  E  T  L     +++PILR LQLLCENHN  LQNFLR Q+
Sbjct: 1835 YALGPSLRRGHEVGERVQSNEMGTSVL-----IMQPILRFLQLLCENHNRDLQNFLRCQN 1889

Query: 6196 DRTNHNLVSETLSFLDTVCGSTKGSLGVFG-EIGEHNFSLITQTLATLTEFCQGPCHENQ 6372
            ++TN+NLV ETL FLD +CGST G LG+ G  I E N  L+ QTL TLTE+CQGPCHENQ
Sbjct: 1890 NKTNYNLVCETLQFLDIMCGSTTGGLGLLGLYINEDNVGLVIQTLETLTEYCQGPCHENQ 1949

Query: 6373 NTMAMQE-NGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIMESRHDGENANRV 6549
              +   E NG++II +L+LN+I PL    M+L L++K  ASKLLLA+MESRHD ENA R+
Sbjct: 1950 TCIVTHESNGIDIITALILNDISPLCKYRMDLVLQLKDNASKLLLALMESRHDSENAERI 2009

Query: 6550 LRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLKKKSGPQITVNTV 6729
            L     +S  P++LV  IK+AY                  R+  D   ++ G  I +  +
Sbjct: 2010 L-----ISLRPQELVDVIKKAYLQEEE-------------RENSDVSPREVGHNIYILAL 2051

Query: 6730 TLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNIYILAHQLAIHDGEL 6909
             L   N         H  K +    +++                    ++  L++++ +L
Sbjct: 2052 QLSRHNKQLQ-----HLLKPVKRIQEEEAEG-----------------ISSMLSLNNKQL 2089

Query: 6910 EIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPINDICSYLTKDTKDYV 7089
               L  S   ++    + L YY+  T+QIEIVR+DR++E++VFP+  IC +LT++TK  +
Sbjct: 2090 TQMLKSSAPVQEQ-EEDPLAYYENHTSQIEIVRQDRSMEQIVFPVPGICQFLTEETKHRL 2148

Query: 7090 YNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIV 7269
            +  TE+D QGSKV++ FD+   +++EM WQRKL+    + W + R+ LW  +SF+ A  +
Sbjct: 2149 FTTTEQDEQGSKVSDLFDQPSFLHNEMEWQRKLRSMPLIYWFSRRMTLWGSISFNLAVFI 2208

Query: 7270 NALVARYYPLPEHSNSSI---SLGNLYSWFAVFSSFLLAHYLRHDKIYLHKTXXXXXXXX 7440
            N ++A +YP  E +++ +    L +L  W  +  S       R+       +
Sbjct: 2209 NIIIAFFYPYVEGASTGVLGSPLISLLFWILICFSIAALFTKRY-------SVRPLIVAL 2261

Query: 7441 XXXXXXXIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRNLHYLLVYLF 7620
                   +G+  TL I G L L NKIV VV+FV N+G   R    ++      Y + Y+
Sbjct: 2262 ILRSIYYLGIGPTLNILGALNLTNKIVFVVSFVGNRGTFIRGYKAMVMDMEFLYHVGYIL 2321

Query: 7621 ICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALILLYFFSILGF 7800
              +LGL  H + Y ILLFD+I+ EETL NVI SVTRN +SI+ T LLALIL+Y FSI+GF
Sbjct: 2322 TSVLGLFAHELFYSILLFDLIYREETLFNVIKSVTRNGRSILLTALLALILVYLFSIVGF 2381

Query: 7801 LYFRHDFYLEVDPVENDSSATISSGIPS------ETCPSEGCP-----GLQPSXXXXXXX 7947
            L+ + DF LEVD +  + S     G+P        TC  +         +
Sbjct: 2382 LFLKDDFILEVDRLPGNHSRANPLGMPHGAATFVNTCSGDNVDCVSGVSVPEVLAEDEEP 2441

Query: 7948 XXXXXSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTXXXXXXXXX 8127
                 +C+TL MCI+     GLRNGGG+GD+LR P+  E +F  RV YD+
Sbjct: 2442 DSTERACDTLLMCIVTVMNHGLRNGGGVGDILRKPSKDESLFPARVVYDLLFFFIVIIIV 2501

Query: 8128 XXXXXXXXXDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHY 8307
                     DTF DLR+EK +KE+ILK  CFICGL+R +FDN++V+FE H + EHN+W+Y
Sbjct: 2502 LNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKFEHNMWNY 2561

Query: 8308 LYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQ 8487
            LY+IV++++K++T++TGPESYVAQ +K++NLDWFPRM+A+SL  SE + +Q+E++ ++D+
Sbjct: 2562 LYFIVLVRVKNKTDYTGPESYVAQMIKNKNLDWFPRMRAMSLVSSEGEGEQNEIRILQDK 2621

Query: 8488 LLQMMTLMREIISQNEESRAFMEQFQPR 8571
            L   M L+  + +Q  E +  M + + R
Sbjct: 2622 LSATMKLVSHLTAQLSELKEQMTEQRKR 2649


>gi|31217824|ref|XP_316515.1| ENSANGP00000004303 [Anopheles gambiae]
 gi|30176080|gb|EAA11872.2| ENSANGP00000004303 [Anopheles gambiae str.
            PEST]
          Length = 2636

 Score = 1541 bits (3989), Expect = 0.0
 Identities = 1029/2832 (36%), Positives = 1494/2832 (52%), Gaps = 117/2832 (4%)
 Frame = +1

Query: 385  AADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRA 564
            AA+ E+++NESE +K LG V+QYGS+VQLLH+KSNKY+TV    PA  E+NAM+VYLD
Sbjct: 3    AAEIEKKQNESENKKLLGTVVQYGSVVQLLHLKSNKYVTVNIRLPALLEKNAMRVYLDAN 62

Query: 565  GNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLS-SFNLLDHQS 741
            GNEGSWF I P YK  + GDNV   +K+ L P + +       +  LH++ ++ L D+
Sbjct: 63   GNEGSWFYIMPFYKLRSAGDNVVVSDKVILKPVNAN-------RQNLHVAVTYELPDNPG 115

Query: 742  AAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDV 921
            + EVN LN  T W++ +F+   ENQ++ +K GDVVRLFHA+Q+ FLT+D   KQ
Sbjct: 116  SKEVNVLNSSTSWKITLFMEQRENQEDVLKGGDVVRLFHAEQEKFLTMDEYKKQQH---- 171

Query: 922  VFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQV 1101
            VFLR T R SA  ATSS+ALWEV+VVQ ++ RGG   WN  +RFKHLAT  YL+AE
Sbjct: 172  VFLRTTGRSSATAATSSKALWEVEVVQHDSCRGGAGHWNSLFRFKHLATGYYLAAE---- 227

Query: 1102 QVKPAMNGRPPLLSALSQKSRPMLERTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLG 1281
                                               D     T +S+ ++       + L
Sbjct: 228  ----------------------------------IDEDISRTEKSSSSSHPQGGDSFRLV 253

Query: 1282 PTKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYS 1461
            P        D   +F+LD +T  +    VP+ SYVRL H  S  WVHAT+     +
Sbjct: 254  PVPHS---SDIASVFELDSTTITRPEGLVPQSSYVRLRHLCSSTWVHATSVPIDID---- 306

Query: 1462 SKNEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISK 1641
              ++    KV C   + DKE F L+PV+P EVRDLDFANDACK L      ++ G + S
Sbjct: 307  -DDKPVMSKVGCSAIKEDKEAFQLIPVSPVEVRDLDFANDACKLLLAMSTKLENGTISSN 365

Query: 1642 ESINSTTQLLIDCILFVTNSSD--HLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKA 1815
            E   S   LL D + F+    +  + +D L ++  +P+RDRQKLLREQ +L Q+F +L+
Sbjct: 366  ER-RSLIALLQDIVFFIAGQENDQNKSDALDLTINNPNRDRQKLLREQYILKQLFKILQG 424

Query: 1816 PFLPRQGTTXXXXXXXXXXXXXDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGE 1995
            PF   Q T              D +N  FK +F+LCY +LK SQ  YRKNQE++A+ FG
Sbjct: 425  PF---QETKNNDGPFLKIDELGDPKNAPFKNIFRLCYRILKLSQQDYRKNQEYIAKHFGL 481

Query: 1996 IQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNR---QGKFLDYLADL 2166
            +Q+QIG+D++AEDT+TA+LHNN KLLEK++    +E FV LVR N    Q +FLDYL+DL
Sbjct: 482  MQKQIGYDILAEDTITALLHNNRKLLEKHITAAEIETFVGLVRKNMQSWQSRFLDYLSDL 541

Query: 2167 CVCRGEANKKIQELICTSVLSSKHRDIFMDTKIID---------GEIEVG---------- 2289
            CV   +A    QELIC SVLSSK+ DI ++T + +          E+E G
Sbjct: 542  CVSNKKAIAVTQELICKSVLSSKNADILIETFLREVDDDPLGYLSELERGNHEKKRYEVV 601

Query: 2290 --WA--PNFRKLVDIAEGAK-SNSDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPERRL 2454
              W      + +  +A+G K   + D   LDYYRHQL+L S MC  +QYLA++
Sbjct: 602  LMWTNRTQSKSMSRLAQGLKIGRAVDTAILDYYRHQLNLFSNMCLNRQYLALN------- 654

Query: 2455 MNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLHLHVVRG--SPMSAIRHARLWWSIPE 2628
             N+S  L  +L+L+CMSD  +PYDLR SF RLMLHLHV R    P++ +++ARLW  IP
Sbjct: 655  -NLSPHLDIDLILRCMSDKTVPYDLRASFCRLMLHLHVDRDPQEPVTPVKYARLWSEIPT 713

Query: 2629 NVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATVETYLMGLRNQSMEERQSVNSSKLTY 2808
             ++++ Y+   +E   D ++  +     +K +A VE YL       M      + +KLT+
Sbjct: 714  VMSINDYD---IEKQLDSNKEAV-RARFNKTIAFVEDYLCNHVVSKMWFADQ-DQNKLTF 768

Query: 2809 EIVNLAKALAQFNFYSFNDLLQLTQNLLAII-----NEGPATEQVPSH--RAMVNAIRNM 2967
            E+V LA+ L  F FYSF+DLL+LT+ LL I+     +E   T     H    ++  I +M
Sbjct: 769  EVVKLARDLIYFGFYSFSDLLRLTKTLLNILDCVSSSEADGTGLPTGHIDCGVLRRIGDM 828

Query: 2968 SKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKTKLIVAEILQFVMDVRRDYRI 3147
               M        S  +        +   +  +   L + TKL + EILQF++DVR DYRI
Sbjct: 829  GAVMTSLTLGPISTAIVSPTIQHRKSVSQLMKEYPLVMDTKLKIIEILQFILDVRLDYRI 888

Query: 3148 TMALSWFKNVFPCDE-------DGSLMHSA-SINERMAS-ELYDAIYRSSG--------- 3273
            +  LS FK  F  +E       D SL  +A +IN R  + +L    Y++ G
Sbjct: 889  SCLLSIFKREFDENEQTASTATDTSLPPTAENINLRQKNIDLESIGYQAEGIFGCTEDTY 948

Query: 3274 HELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNN 3453
            + L LDG+ G+  L +LL + M +YP L S AL + FRHF+Q  E+L   +QVQLLVS++
Sbjct: 949  NPLDLDGQGGRTFLRVLLHLIMHEYPALVSGALHLLFRHFSQRHEVLHAFRQVQLLVSDS 1008

Query: 3454 DVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPRA 3633
            DVE+Y+QI  DL +L+   EKSELWV+        +K+ D             DL +
Sbjct: 1009 DVESYKQIKSDLDVLRQSVEKSELWVY-------KSKQTD-------------DLLAGGG 1048

Query: 3634 FDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLI 3813
             + G+  +       E  P +  E  Q                             Y  I
Sbjct: 1049 GEGGEGGDGSGGKGGEQGPELNPEQSQ----------------------------EYKKI 1080

Query: 3814 RQMLVRLTGMCYRKGDP----KPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLI 3981
            +Q+L+R+  +C     P    KP    Q+LL+N+ V+ VVL+ + +P+D+K D+ M +L+
Sbjct: 1081 QQILIRMNKLCITATGPDGFVKPRKHEQRLLRNVGVHTVVLDLLQIPYDEKDDYRMNELM 1140

Query: 3982 TLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASN 4161
             L+HEFL++FC  N++NQ  L+K    +     G+L  ET+       AIF++N  L +
Sbjct: 1141 RLAHEFLQNFCLGNQQNQILLHK--QLDLFLNPGILEAETV------CAIFKDNLNLCNE 1192

Query: 4162 VPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYV 4341
            V ++++ H V  IE + R+  +L+ LQ ++   ++ I   Q+ V  E+  A +EV   Y
Sbjct: 1193 VSDKVVQHFVHCIEIHGRHVEYLKFLQTIIKAENQFIRKCQDMVMQELVNAGEEVLVFYN 1252

Query: 4342 DNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPM 4521
            D  SF     +M+    S G  +D    L YHIELV+LLA CT GKN  TE+KC S + +
Sbjct: 1253 DKGSFNYFVELMR--SYSAGTLADP-SPLMYHIELVKLLACCTMGKNVYTEIKCNSLLAL 1309

Query: 4522 DHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHIL-NNLLEDIRSLR 4698
            D IV +++   C+ EVK  Y+  L HCYIDT+ E+K+ Y + ++  +   + L DI +
Sbjct: 1310 DDIVAMISHPDCIPEVKVAYVDFLCHCYIDTEVEVKEIYSSNHMWCLFEKSFLIDINN-- 1367

Query: 4699 VEKLTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLE 4878
            V K        LE+Y+C+ V  +L  FF + +S    A   +   +  F ++L     L
Sbjct: 1368 VVKGGSFTNKQLENYVCNEVMNILTTFFNSQFSDQSTA---LQKRQLIFVKILQNSFKLT 1424

Query: 4879 KGKLRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGP--QMSGQTSVRQKWQQAAS 5052
            + K  G   S+  + V  CI+ L++ A+   I +P  L     +M  +T++  +
Sbjct: 1425 QCK--GLTPSQR-FNVENCIRTLSEKAKPRGIAIPIDLENQVVKMFNKTAMLSR-----Q 1476

Query: 5053 SAKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAE 5232
            ++KW+ + K+   +            S S       +++     ++   +  L PL  AE
Sbjct: 1477 TSKWLLVTKQTKMER-----------SQSQIMRMDRSIIEGLQDIVSLLEDKLKPLVEAE 1525

Query: 5233 GSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKM 5412
             S+LV++L+  ELLFP  +  R +C  G  +  LI+H + L++ K++ LC ++L+TL +M
Sbjct: 1526 QSLLVDILYRSELLFPLNTESRKKCETGDFIRHLIKHTEKLLEEKEEKLCVKILKTLKEM 1585

Query: 5413 --CDCTKQQLTHQGHRVYNSSVEKGXXXXXXXXXXYFGHHNNHHPPLDRQQSXXXXXXXX 5586
               DC                 +KG          YFG+      P+
Sbjct: 1586 MTIDC--------------DYGDKGDHLRTILLKRYFGNDFTLQAPVAALPGAVGPAVLQ 1631

Query: 5587 XXXXXXXTWS----------------QERDLYAIQCKLNDAGASDLVTDIIIME-PSREI 5715
                     S                  R L+ +Q  L+  GASDLV +++I    S  I
Sbjct: 1632 PANVSTAVGSPMASVSHGPGAKYLIRAGRTLHEVQNHLDKEGASDLVIELVIKSINSPSI 1691

Query: 5716 FLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRLKSDM-MSCS 5892
            F++AI L  ALL  GN  +Q   Y +    D+ + FFK    +++ AQ  +KS + ++ S
Sbjct: 1692 FVEAIELGIALLEGGNPIIQKGMYNKFLSNDLSQSFFKVFFDKMKDAQQEIKSTVTVNTS 1751

Query: 5893 DSKPKVSSTVLTPLIDAGDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQD 6072
            D +               D G   +L  +        ++E              L  ++D
Sbjct: 1752 DGEQGKRKQAAASDGTGSDNGDENSLMSIGSSALEDILAE-------------KLEKHKD 1798

Query: 6073 EEKSTDALPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVC 6252
            ++++ + L  +V +++PILR LQLLCENHN  LQN LR Q+++TN+NLVSETL FLD +C
Sbjct: 1799 KDEN-NKLSNKVLVMQPILRFLQLLCENHNPELQNLLRNQNNKTNYNLVSETLMFLDCIC 1857

Query: 6253 GSTKGSLGVFG-EIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQE-NGLNIIISLVL 6426
            GST G LG+ G  I E+N SLI QTL TLTE+CQGPCH+NQN +A  E NGL+II +L+L
Sbjct: 1858 GSTTGGLGLLGLYINENNVSLINQTLETLTEYCQGPCHDNQNCIATHESNGLDIITALIL 1917

Query: 6427 NEIKPLADDHMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIK 6606
            N+I PL  + M+L LE+K+ ASKLLLAIMESR D ENA R+L NM      PKQLV
Sbjct: 1918 NDINPLGKNRMDLVLELKNNASKLLLAIMESRGDSENAERILANM-----NPKQLVEVAC 1972

Query: 6607 QAYEMTNSNHHMLKSISRDLFRQAEDD-----LKKKSGPQITVNTVTLPEINVDASGIVS 6771
            +A      + +    +  DL     DD       K+ G  I +    L + N + +G++
Sbjct: 1973 RAGGGGVDDGY--GGLRHDLGDDGHDDDDVGVSPKEVGHNIYILCHQLAQHNKELAGLLK 2030

Query: 6772 IHTEKNISSSLDDKFN-DDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKKDD 6948
            I T     ++  +        P  +P  +G      A              + +  K +
Sbjct: 2031 IDTYNGSGTAGSNAAPIVPTFPGANPSSLGGGPPSSAS------------ANSAASKANS 2078

Query: 6949 LTREALNYYKERTAQIEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKV 7128
             T +AL YY+  TAQIEIVR DRTLE++VFPI +IC YLTKDTK  V N  ERD+QGSKV
Sbjct: 2079 KTNQALLYYQTHTAQIEIVRHDRTLEQIVFPIPEICEYLTKDTKVRVLNTAERDDQGSKV 2138

Query: 7129 TEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYP---- 7296
             +FFD  E M++EM WQ+KL+ +  L W +  + LW+ + F+ A ++N +VA +YP
Sbjct: 2139 ADFFDRHEAMFNEMKWQKKLRGQPALFWVSSYMSLWSNILFNLAVLINLIVAFFYPFENA 2198

Query: 7297 LPEHSNSSISLGNLYSWFAVFSSFLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTL 7476
            LPE S    SL     W  +  S  +   L                          G
Sbjct: 2199 LPELSFHLSSL----IWIVMLVSLAIVITLPR-----QSGIRTFVVALILRLIFSCGPEP 2249

Query: 7477 TLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMI 7656
            TL++ G + ++ K VH+++ + N G  ++    I+    L Y   YL  C+ G+L+HP
Sbjct: 2250 TLWLLGCITVIMKGVHIISLMGNYGTLEKHFVSIITDAELLYHFFYLLFCVFGVLLHPFF 2309

Query: 7657 YCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVD 7836
            + ILLFD+++ EETL NVI SVTRN +SI+ T +LALIL+Y FSI+G+++FR DF + VD
Sbjct: 2310 FSILLFDVVYREETLLNVIRSVTRNGRSIILTAVLALILVYMFSIIGYMFFRDDFLVPVD 2369

Query: 7837 --------PVENDS-----SATISSGIPSE--------TCPSEGCPGLQPSXXXXXXXXX 7953
                    P   D+     SAT+S  +P +        TC     PG   +
Sbjct: 2370 EEYTPPAIPTAGDAGCTGDSATVSHMVPPDVVDQVVQATCSKP--PGTASTELADDGGEM 2427

Query: 7954 XXXSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTXXXXXXXXXXX 8133
                C+++ MCI+ T  QGLRNGGGIGD+LR P+  E +F+ RV YD+
Sbjct: 2428 KERGCDSMIMCIITTLNQGLRNGGGIGDILRAPSRKETLFVPRVVYDLLFFFIVIIIVLN 2487

Query: 8134 XXXXXXXDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLY 8313
                   DTF DLR+EK +KE ILKN CFICGL+RS FDN++V+FE H + EHN+WHYLY
Sbjct: 2488 LIFGVIIDTFADLRSEKQQKELILKNTCFICGLNRSAFDNKTVSFEEHIKNEHNMWHYLY 2547

Query: 8314 YIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLL 8493
            +IV++++KD TEFTGPESYV   VK    DWFPR++A+SL   + D +Q E++ +K+ L
Sbjct: 2548 FIVLVKVKDPTEFTGPESYVHAMVKANIQDWFPRLRAMSLAAVDGDGEQIELRSLKNLLE 2607

Query: 8494 QMMTLMREIISQ 8529
                 +RE+++Q
Sbjct: 2608 TNHIAVRELMTQ 2619


>gi|50760465|ref|XP_418035.1| PREDICTED: similar to Inositol
            1,4,5-trisphosphate receptor type 3 (Type 3 inositol
            1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor)
            (IP3 receptor isoform 3) (InsP3R3) [Gallus gallus]
          Length = 3027

 Score = 1271 bits (3288), Expect = 0.0
 Identities = 866/2563 (33%), Positives = 1330/2563 (51%), Gaps = 142/2563 (5%)
 Frame = +1

Query: 1309 DANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWVK 1488
            D   LF+LDP+T  K++  VPR SYVRL H  ++ W+ +TN      +    +     +
Sbjct: 656  DIASLFELDPTTLQKTDSFVPRNSYVRLRHLCTNTWIQSTNVP----IDIDEERPIRLML 711

Query: 1489 VICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQL 1668
              C   + DKE FA++ V   E+RDLDFANDA   L N ++ +  G  +S+       QL
Sbjct: 712  GTCP-TKEDKEAFAIVSVPVSEIRDLDFANDASSMLANVVEKMNEG-FLSQNDRRFVIQL 769

Query: 1669 LIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXX 1848
            L D + FV++  ++  + L I    P+R+RQKL+REQ +L Q+F +LKAPF  + G
Sbjct: 770  LEDLVFFVSDVPNNGQNVLDIVVTKPNRERQKLMREQNILKQIFGILKAPFKDKGGE--- 826

Query: 1849 XXXXXXXXXXXDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMA 2028
                       D +N  ++ MF+LCY +L++SQ  YRKNQE +A++FG +Q QIG+D++A
Sbjct: 827  -GPLVRLEELSDQKNAPYQYMFRLCYRVLRHSQEDYRKNQEHIAKQFGMMQSQIGYDILA 885

Query: 2029 EDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEANKKIQEL 2208
            EDT+TA+LHNN KLLEK++    VE FV LVR NR+ +FLDYL+DLCV    A    QEL
Sbjct: 886  EDTITALLHNNRKLLEKHITKTEVETFVSLVRKNREPRFLDYLSDLCVSNHIAIPVTQEL 945

Query: 2209 ICTSVLSSKHRDIFMDTKI-----------------IDGEIEVGWAP-----NFRKLVDI 2322
            IC  VL  K+ DI + T++                  + E+ + W       + + +  +
Sbjct: 946  ICKCVLDPKNSDILIKTELRPVKEMSQTHEYLSIEYSEEEVWLTWTDKNNDHHEKSIRQL 1005

Query: 2323 AEGAKS-NSDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQC 2499
            A+ A++ N+ D   L YYR+QL L ++MC ++QYLAI          ISQQL  +L+  C
Sbjct: 1006 AQEARAGNAHDENVLSYYRYQLKLFARMCLDRQYLAI--------KEISQQLGVDLIFLC 1057

Query: 2500 MSDNRLPYDLRGSFTRLMLHLHVVRGSP--MSAIRHARLWWSIPENVNVSTYESVSVEAY 2673
            M+D  LP+DLR SF  LMLH+HV R     +  ++ ARLW  IP  + +  Y+S ++ A
Sbjct: 1058 MADEMLPFDLRASFCHLMLHVHVDRDPQELVMPVKFARLWTEIPTAITIKDYDS-NLNAS 1116

Query: 2674 SDGSRMRIGEGIAHKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFY 2853
             D  + +         +  VE YL  + ++++        +KLT+E+V+LA  L  F FY
Sbjct: 1117 RDDKKNKFA-----STMEFVEDYLNNVVSEAVPFANE-EKNKLTFEVVSLAHNLIYFGFY 1170

Query: 2854 SFNDLLQLTQNLLAIINEGPATEQVPSHRAMVNAI-------RNMSKSMMRGGNKENSKD 3012
            SF++LL+LT+ LL II      + V + + M+ A+       +N+ +S+   G   ++
Sbjct: 1171 SFSELLRLTRTLLGII------DCVQNPQLMMQAVYSDEVTGKNVRRSIQGVGQMMSTMV 1224

Query: 3013 LAK------TPSVTAEEA------GRTKEGRALNV-KTKLIVAEILQFVMDVRRDYRITM 3153
            L++       PS++A  A      GR+ E   + V +TKL + EILQF+++VR DYRI+
Sbjct: 1225 LSRKQSIFSPPSLSAGSAPEPVDRGRSVENENIVVMETKLKILEILQFILNVRLDYRISY 1284

Query: 3154 ALSWFK----NVFPCDE---DGSL----MHSASINERMASELYDAIY--RSSGHELHLDG 3294
             LS FK     V+P  +   DG+       +A++N     E  +A++    +   L +D
Sbjct: 1285 LLSVFKKEFVEVYPMQDSAADGTAPAFDSTTAAMNLDRIGEHAEAMFGVGKTSSMLEVDD 1344

Query: 3295 RDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLK---------------- 3426
              G++ L +L+ +TM DYPPL S +L++ F+HF+Q QE+L   K
Sbjct: 1345 EGGRMFLRVLIHLTMHDYPPLISGSLQLLFKHFSQRQEVLHTFKQVTLERLHLMASLLWE 1404

Query: 3427 -------------------------QVQLLVSNNDVENYRQIDRDLFILKNLTEKSELW- 3528
                                     QVQLL+S  DVENY+ I  +L  L+ + EKSELW
Sbjct: 1405 EIQARRGVGFMPQTSCTGKSLGMSLQVQLLISAQDVENYKVIKSELDKLRTMVEKSELWV 1464

Query: 3529 -----VHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPS 3693
                 V GD   ++D  + ++KE T + +++    KS                 +E+Y
Sbjct: 1465 DKKGSVKGD--SNVDGNKKEKKEHTADEEVIAPGEKS-----------------SENYQI 1505

Query: 3694 IRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDPKPD 3873
            ++                                        +L RL  MC      +
Sbjct: 1506 VKG---------------------------------------ILERLNKMC--GVGEQVR 1524

Query: 3874 TMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKF 4053
               Q+LLKNM  ++V+L+ + +P++ K D  MM+++  +H+FL+ FC  N+ENQ+ L+K
Sbjct: 1525 KKQQRLLKNMDAHKVMLDLLQIPYE-KGDAKMMEILKFTHQFLQKFCAGNQENQALLHKH 1583

Query: 4054 ISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLE 4233
            ++       G+L  ET++       IF NN +L S + E +  H +  +  + R+  +L+
Sbjct: 1584 LNL--FLTPGLLEAETMQH------IFLNNYQLCSEINETVPQHFIHCVATHGRHVQYLD 1635

Query: 4234 LLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSD 4413
             L  ++    K ++  Q+ +  E+  A D+V   Y D AS   L  MM   ++    +S
Sbjct: 1636 FLHTIIKAEGKYVKKCQDMIMTELTNAGDDVVVFYNDKASLATLLEMMTAARDGVEENS- 1694

Query: 4414 SRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLL 4593
                L YHI LV LLA C  GKN  TE+KC S +P++ +VRVVT + C+ EVK  Y+  +
Sbjct: 1695 ---PLMYHISLVDLLAACAEGKNVYTEIKCTSLLPLEDVVRVVTHEDCITEVKMAYVNFV 1751

Query: 4594 LHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEKLTGAETATLEHYICHTVTEVLI 4773
             HCY+DT+ EMK+ Y + ++  +  N   D+  +  ++       TLE Y+   V + +
Sbjct: 1752 NHCYVDTEVEMKEIYTSNHIWTLFENFTLDMAQMCKKREKRLPDPTLEKYVLTVVLDTIN 1811

Query: 4774 KFFEAPYSALQQAKVDVHHHKKTFSEV------LLELTYLEKGKLRGSKSSRNWYRVAEC 4935
             FF +P+S   +    +  H+    ++      LLE ++L+    +  KSS     V  C
Sbjct: 1812 AFFSSPFS---ENSTSLQTHQTIVVQLLQSTMRLLECSWLQ----QQHKSS-----VEAC 1859

Query: 4936 IKRLTKWAEE---HNITLPA--------TLAGPQMSGQTSVRQKWQQAASSAKWIGIGKR 5082
            I+ L    +E    +  LPA          + P  +   S+       A  +  +
Sbjct: 1860 IRTLAMVGKELCRRDALLPACQRDAAALAASAPAAAKSRSIALPMDLDAHVSSLLNSSST 1919

Query: 5083 LNRQNTLNPGHRLYGT----SNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVE 5250
               Q   +       T    S +  +    N++     +I   +  L PL  AE SVLV+
Sbjct: 1920 STVQRNTSSYKTATRTFPRVSTTPNQWDYKNIIEKLQDIINALEDRLKPLVEAELSVLVD 1979

Query: 5251 VLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKQ 5430
            VLH PELLF EG+    +C  GG ++KL+QH K LM+  ++ LC +VL+TL       +Q
Sbjct: 1980 VLHRPELLFMEGTEAYQRCESGGFLSKLVQHTKDLMET-EEKLCIKVLRTL-------QQ 2031

Query: 5431 QLTHQGHRVYNSSVEKGXXXXXXXXXXYFGHHNNHHPPLDRQQSXXXXXXXXXXXXXXXT 5610
             L  +     N   E+G          Y           +++ S
Sbjct: 2032 MLVKR-----NKYGERGNLLRKMLLNNYL---------QNKKSSSKGEIVDAAGGGQDQD 2077

Query: 5611 WSQERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYM 5790
            WS    + A+QC+L+  GA+ LV D+I+   + +IF ++I LA  LL  GN ++Q SFY
Sbjct: 2078 WSA---IAAVQCRLDREGATKLVADLIMNTKNEKIFQESILLAIRLLDGGNTEIQKSFYN 2134

Query: 5791 RMKQKDIHEPFFKAILTRIQTAQNRLKSDM---MSCSDSKPKVSSTVLTPLIDAGDTGFN 5961
             M      E FFK +  R++ AQ   KS +   MS   +KP+       P      T
Sbjct: 2135 LMTSDKKSEKFFKVLHDRMKKAQQETKSTVSVNMSDIGNKPREDKDEPDP-----GTKGR 2189

Query: 5962 GALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPEVALVEPILRVLQ 6141
            G  F +P       ++   +  +D             E+   + +   V ++EPILR LQ
Sbjct: 2190 GETFMMPGTPSRYPLALGFRKGHD-----------TGEQGQNNEMGVTVLIMEPILRFLQ 2238

Query: 6142 LLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFG-EIGEHNFSLIT 6318
            LLCENHN  LQNFLR Q+++TN+NLV ETL FLD +CGST G LG+ G  I E+N +LIT
Sbjct: 2239 LLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDIMCGSTTGGLGLLGLYINEYNVALIT 2298

Query: 6319 QTLATLTEFCQGPCHENQNTMAMQE-NGLNIIISLVLNEIKPLADDHMELALEIKSQASK 6495
            QTL TLTE+CQGPCHENQ+ +   E NG++II +L+LN+I PL    M+L L++K  ASK
Sbjct: 2299 QTLETLTEYCQGPCHENQSCIVTHESNGIDIITALILNDISPLCKYRMDLVLQLKDNASK 2358

Query: 6496 LLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDLFRQ 6675
            LLLA+MESRHD ENA R+L     +S  P++LV  IK+AY            +  +
Sbjct: 2359 LLLALMESRHDSENAERIL-----ISLRPQELVDVIKKAY------------LQEEECEN 2401

Query: 6676 AEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDPREV 6855
            AE    ++ G  I +  + L   N     +  +   K I    ++
Sbjct: 2402 AEVS-PREVGHNIYILALQLSRHNKSLQQL--LKPVKRIQEEEEEG-------------- 2444

Query: 6856 GHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTLERVV 7035
                  ++  L++++ +L   L  +   +++   + L YY++ T+QIEIVR DR++E+++
Sbjct: 2445 ------ISSMLSLNNKQLTQMLKSTAPVQEE-EEDPLAYYEKHTSQIEIVRLDRSMEQII 2497

Query: 7036 FPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWLSWC 7215
            FP+  IC +LTK+TK  ++  TE+D QGSKV++FFD+   +++EM WQ+KL+    + W
Sbjct: 2498 FPVPGICEFLTKETKYRLFTTTEQDEQGSKVSDFFDQSSFLHNEMEWQKKLRSMPLMYWF 2557

Query: 7216 AFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSI---SLGNLYSWFAVFSSFLLAHYL 7386
            + R+ LW  +SF+ A  +N ++A +YP  E ++  +    L +L  W  +  S +
Sbjct: 2558 SRRMTLWGSISFNLAVFINIIIAFFYPYVEATSMGVLDSPLISLLFWILICFSIMALFTK 2617

Query: 7387 RHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRP 7566
            R+    L                  +G+ LTL I G L L NKIV VV+FV N+G   R
Sbjct: 2618 RYGVRPL-------LVALILRSIYYLGIGLTLNILGALNLTNKIVFVVSFVGNRGTFIRG 2670

Query: 7567 IAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIV 7746
               ++      Y + Y+   +LGL VH + Y ILLFD+I+ EETL NVI SVTRN +SI+
Sbjct: 2671 YKAMIMDVEFLYHVGYILTSVLGLFVHELFYSILLFDLIYREETLFNVIKSVTRNGRSIL 2730

Query: 7747 WTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIP------SETCPSE-- 7902
             T LLALIL+Y FSI+GFL+ + DF LEVD + +  +     G+        E+C  +
Sbjct: 2731 LTALLALILVYLFSIVGFLFLKDDFILEVDRLPDSKAQDDPLGMQRNMETFMESCSGDKI 2790

Query: 7903 GCPGLQPSXXXXXXXXXXXXSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWR 8082
             C  + P+            +C+TL MCI+     GLRNGGG+GD+LR P+  E +F  R
Sbjct: 2791 SCSAV-PTALQEADTDQWERACDTLLMCIVTVLNHGLRNGGGVGDILRKPSKDESLFPAR 2849

Query: 8083 VAYDMTXXXXXXXXXXXXXXXXXXDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSV 8262
            V YD+                   DTF DLR+EK +KE+ILK  CFICGL+R +FDN++V
Sbjct: 2850 VVYDLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTV 2909

Query: 8263 TFETHRETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDS 8442
            +FE H + EHN+W+YLY+IV++++K++T++TGPESYVAQ +K++NLDWFPRM+A+SL  +
Sbjct: 2910 SFEEHIKYEHNMWNYLYFIVLVRVKNKTDYTGPESYVAQMIKNKNLDWFPRMRAMSLVSN 2969

Query: 8443 ELDTDQSEVKQMKDQLLQMMTLMREIISQNEESRAFMEQFQPR 8571
            E + +Q+E++ ++D+L   M L+  + SQ  E +  M + + R
Sbjct: 2970 EGEGEQNEIRNLQDKLNSTMKLVSHLTSQLNELKEQMTEQRKR 3012



 Score =  211 bits (536), Expect = 3e-52
 Identities = 115/269 (42%), Positives = 159/269 (58%), Gaps = 36/269 (13%)
 Frame = +1

Query: 190  LVDDRCIVELKDGRPESPPKKFR------------------------------------D 261
            LVDDRC+VE   G  ++PPKKFR                                    D
Sbjct: 331  LVDDRCVVEPAAGDLDNPPKKFRALPQPYILAHQEEANGMPQFCAQQDLSPPPILKKIPD 390

Query: 262  CLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGN 441
            CLFKVCP+NRY+AQK  W  ++  Q  + + D  L+ KL+ AA  E+++NE+E +K  G+
Sbjct: 391  CLFKVCPMNRYSAQKQYWKAKQTKQDKEKIADVVLLQKLQHAAQMEQKQNETENKKVHGD 450

Query: 442  VIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIG 621
            V++YGS++QLLH+KSNKY+TV K  PA  E+NAM+V LD  GNEGSW  I+P +K  + G
Sbjct: 451  VVKYGSVIQLLHMKSNKYLTVNKRLPALLEKNAMRVTLDATGNEGSWLFIQPFWKLRSNG 510

Query: 622  DNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLL 801
            DNV  G+K+ L P       AG     LH S++ L D+    EVN +N  T W++ +F+
Sbjct: 511  DNVVVGDKVILNP-----VNAG---QPLHASNYELADNAGCKEVNSVNCNTSWKINLFMQ 562

Query: 802  FDENQQNSVKSGDVVRLFHADQQTFLTLD 888
            F ++ +  +K GDVVRLFHA+Q+ FLT D
Sbjct: 563  FRDHMEEVLKGGDVVRLFHAEQEKFLTCD 591


>gi|476810|pir||A40743 IP3 receptor, XIP3R - African clawed frog
 gi|464220|dbj|BAA03304.1| inositol 1,4,5-triphosphate receptor
            [Xenopus laevis]
          Length = 2693

 Score = 1229 bits (3181), Expect = 0.0
 Identities = 835/2273 (36%), Positives = 1209/2273 (52%), Gaps = 104/2273 (4%)
 Frame = +1

Query: 109  LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
            LH+GDI+SLY E S N    GF++TLGLVDDR +V+   G   +PPKKFRDCLF++CP+N
Sbjct: 9    LHVGDIVSLYAEGSVN----GFINTLGLVDDRSVVQPDAGDLNNPPKKFRDCLFRLCPMN 64

Query: 289  RYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQ 468
            RY+AQK  W   K      S  D  L+NKL  AAD E+++NE+E +K LG VIQYG+++Q
Sbjct: 65   RYSAQKQFWKAAK--PGASSTTDTVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQ 122

Query: 469  LLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKI 648
            LLH+KSNKY+TV K  PA  E+NAM+V LD AGNEGSWF I+P YK  +IGD+V  G+K+
Sbjct: 123  LLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGDKV 182

Query: 649  SLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSV 828
             L P       AG     LH SS  L D+    EVN +N  T W++ +F+ + +N+ + +
Sbjct: 183  VLNP-----VNAGQ---PLHASSQQLSDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDIL 234

Query: 829  KSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTN 1008
            K GDVVRLFHA+Q+ FLT D   K+      VFLR T R SA  ATSS+ALWEV+VVQ +
Sbjct: 235  KGGDVVRLFHAEQEKFLTCDEHRKKQH----VFLRTTGRQSATSATSSKALWEVEVVQHD 290

Query: 1009 AYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRPPLLSALSQKSRPMLERTNN 1188
              RGG   WN  +RFKHLAT  YL+AE         ++  P   +A  Q
Sbjct: 291  PCRGGAGYWNSLFRFKHLATGHYLAAE---------IDAEPDAGNARMQ----------- 330

Query: 1189 PMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEV 1368
                       V  E    T  ++P               D + +F+LDP+T    +  V
Sbjct: 331  -----------VVPEKMMCTLISVPE------------GNDISSIFELDPTTLRGGDSLV 367

Query: 1369 PRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWVKVICEKNRVDKETFALLPVNP 1548
            PR SYVRL H  ++ WVH+TN+   ++     + +   +++     + DKE FA++PV+P
Sbjct: 368  PRNSYVRLRHLCTNTWVHSTNSPIDKD-----EEKPVMLRIGTSPVKEDKEAFAIVPVSP 422

Query: 1549 DEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADPLK 1728
             EVRDLDFANDA K L +    ++ G +   E   + T+LL + + FVT   +   D L+
Sbjct: 423  AEVRDLDFANDASKVLSSIAGKLEKGTITQNER-RAVTKLLEELVYFVTGLVNSGHDILE 481

Query: 1729 ISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIFKT 1908
            +    P+R+RQKL+REQ +L Q+F LL+APF     T              D R+  F+
Sbjct: 482  VLVNKPNRERQKLMREQNILKQIFKLLQAPF-----TDSGDGPMLRLEELGDQRHAPFRH 536

Query: 1909 MFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVK 2088
            + +LCY +L++SQ  YRKNQE++A++FG +Q+QIG+D++AEDT+TA+LHNN KLLEK++
Sbjct: 537  ICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKHIT 596

Query: 2089 TPHVERFVELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKII 2268
               ++ FV LVR NR+ +FLDYL+DLCV   ++    QELIC +VL+  + DI ++TK++
Sbjct: 597  AAEIDTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPANADILIETKLV 656

Query: 2269 ------------DGEIEVG---------WAPN-----FRKLVDIAEGAK-SNSDDAEHLD 2367
                        +  +E G         W  +      R + ++A+ AK    +D + L+
Sbjct: 657  LSRFEFEGVASGESSLEAGEDEEEVWLFWKASNKEIRSRSVRELAQDAKEGQKEDQDVLN 716

Query: 2368 YYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTR 2547
            YYR+QL+L ++MC ++QYLAI+         IS QL  +L+L+CMSD  LP+DLR SF R
Sbjct: 717  YYRYQLNLFARMCLDRQYLAIN--------EISGQLDVDLILRCMSDENLPFDLRASFCR 768

Query: 2548 LMLHLHVVRG--SPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKV 2721
            LMLH+HV R     ++ +++ARLW  IP  + +  Y+S      S  SR  I E  A +
Sbjct: 769  LMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDS------SGTSRDDIKERFA-QT 821

Query: 2722 LATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAII 2901
            +  VE YL  +  Q          +KLT+E+VNLA+ L  F FY+F+DLL+LT+ LLAI+
Sbjct: 822  MEFVEEYLRDVVGQRFPFADK-EKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAIV 880

Query: 2902 NEGPATEQVPS--------HRAMVNAIRN-------MSKSMMRGGNKENSKDLAKTPSVT 3036
            +        PS         +   N +R+       M++ ++RGG       +A  P  T
Sbjct: 881  DCVHLIANFPSGKLGKGEESKGGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMA-APEGT 939

Query: 3037 AEEAGRTKEGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHS- 3213
             +     ++   L + TKL + EILQF+++VR DYRI+  L  FK+ F      S+  S
Sbjct: 940  IKAQREPEKEDILVMDTKLKIIEILQFILNVRLDYRISCLLCIFKSEFDESNAQSVEGST 999

Query: 3214 -------ASINERMASELYDAIYRSSGHE--LHLDGRDGQLLLAILLQMTMSDYPPLTSI 3366
                    +++     E  + I+  S     L LD   G+  L +LL +TM DYPPL S
Sbjct: 1000 EAITVVPGTLDFEHIEEQAEGIFGGSEENTPLDLDDDGGRTFLRVLLHLTMHDYPPLVSG 1059

Query: 3367 ALKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVH-GDR 3543
            AL + FRHF+Q QE+L+  KQVQLLV++ DV+NY+QI +DL  L+++ EKSELWV+ G
Sbjct: 1060 ALHLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGSG 1119

Query: 3544 HHSIDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLN 3723
               +   +    ++           ++P      +S  +       +Y  ++ E L  L+
Sbjct: 1120 PEEVTAAQAGGADKG----------ETPGKAKKSESTSSY------NYRVVK-EILLRLS 1162

Query: 3724 RLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNM 3903
            +L ++++        Q+      + A+ ++ ++L     + Y K +   DT  Q+++K
Sbjct: 1163 KLCVQENTTGRRNRKQQQRLLRNMGAHSVVLELL----QIPYEKTE---DTRMQEIMK-- 1213

Query: 3904 RVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEG 4083
                                       ++HEFL++FC  N++NQ+ L+K I+
Sbjct: 1214 ---------------------------IAHEFLQNFCAGNQQNQALLHKHIN-------- 1238

Query: 4084 MLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYD 4263
            +     I E  T+  IF NN +L S + E ++ H    IE + RN  +++ LQ +V
Sbjct: 1239 LFLTPGILEAVTMQHIFMNNFQLCSEINERVVQHFAHCIETHGRNVQYIKFLQTIVKAEG 1298

Query: 4264 KEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIE 4443
            + I+  Q+ V  E+  + ++V   Y D ASF+ L  MM+ E+E      D    L YHI
Sbjct: 1299 RYIKKCQDIVMAELVNSGEDVLVFYNDRASFQTLVQMMRSERE----RMDENSPLMYHIH 1354

Query: 4444 LVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAE 4623
            LV LLA+CT GKN  TE+KC S +P+D IVRVVT + C+ EVK  Y+  L HCY+DT+ E
Sbjct: 1355 LVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCVPEVKIAYINFLNHCYVDTEVE 1414

Query: 4624 MKDAYKTEYVDHILNNLLEDIRSLRVEKLTGAE---TATLEHYICHTVTEVLIKFFEAPY 4794
            MK+ Y + ++  +  N L DI   RV   T         LE Y+   V  ++  FF +P+
Sbjct: 1415 MKEIYTSNHMWKLFENFLVDI--CRVCNSTSDRKHADIVLERYVTEIVMSIVNTFFSSPF 1472

Query: 4795 S----ALQQAKVDVHHHKK--TFSEVLLEL--TYLEKGKLRGSKSSRNWYRVAECIKRLT 4950
            S     LQ +K+ V H  +   F ++L  +   Y     L   K+S     V  CI+ L+
Sbjct: 1473 SDQSTTLQASKLAVVHQTRQPVFVQLLQAIFRVYHCNWLLPSQKAS-----VESCIRVLS 1527

Query: 4951 KWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGHRLYGT 5130
              A+   I +P  L     +         Q+ A S  W    +   R++++    R Y
Sbjct: 1528 DVAKSRTIAIPVDLDSQVNNLFLKSHNIVQKTAMS--WRMSVRNAARRDSVLTASRDY-- 1583

Query: 5131 SNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCA 5310
                      N++     ++   +  L PL  AE SVLV+VLH PELLFPE +  R +C
Sbjct: 1584 ---------RNIIERLQDIVSSLEDRLRPLVQAELSVLVDVLHRPELLFPENTDARKKCE 1634

Query: 5311 RGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKQQLTHQGHRVYNSSVEKGXXX 5490
             G  + KLI+H K L++  ++ LC +VLQTL +M    +               +KG
Sbjct: 1635 SGQFICKLIRHTKLLLEENEEKLCIKVLQTLREMMAKDR------------GFGDKGEAL 1682

Query: 5491 XXXXXXXYFGHHNNHHPPLDRQQS-----------XXXXXXXXXXXXXXXTWSQERDLYA 5637
                   Y+G+      P  R++S                              E  L
Sbjct: 1683 RVILVNRYYGNIR----PAGRRESLTSFGNGPLSGGSSGKSGGGSIGSGSLSRSEMSLSD 1738

Query: 5638 IQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHE 5817
            +QC L+  GASDLV D+I+   S  +F ++I LA ALL  GN  +QHSF+ R+ +    E
Sbjct: 1739 VQCHLDKQGASDLVIDLIMNATSDRVFHESILLAIALLEGGNTTIQHSFFCRLTEDKKSE 1798

Query: 5818 PFFKAILTRIQTAQNRLKSDMMSCSDSKPKVSSTVLTPLIDAGDTGFNGALFEVP--QQV 5991
             FFK    R++ AQ  +K+ +            TV T  + +       +  E P  Q+V
Sbjct: 1799 KFFKVFFDRMKVAQQEIKATV------------TVNTSDLGSKKRDEEQSERETPHHQRV 1846

Query: 5992 RHPS----------ISEMSQLSNDLTHSIPDLAPYQDE-----------EKSTDALPPE- 6105
            R PS          + E S  +    +S    A   D            EK  D L
Sbjct: 1847 REPSGQITEEAKEQLIEASVATKKAYYSFRREADPDDHFSLGEGVMAVAEKGRDELEMSA 1906

Query: 6106 -VALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVF 6282
             + +++PILR LQLLCENHN  LQNFLR Q++++N+NLV ETL FLD +CGST G LG+
Sbjct: 1907 VITIMQPILRFLQLLCENHNRDLQNFLRCQNNKSNYNLVCETLQFLDCICGSTTGGLGLL 1966

Query: 6283 G-EIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQE-NGLNIIISLVLNEIKPLADDH 6456
            G  I E N +LI QTL +LTE+CQGPCHENQN +A  E NG++II +L+LN+I PL
Sbjct: 1967 GLYINEKNVALINQTLESLTEYCQGPCHENQNCIATHESNGIDIITALILNDINPLGRKR 2026

Query: 6457 MELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAY 6615
            M+L LE+K+ ASKLLLAIMESRHD ENA R+L NM      PK+LV  IK+AY
Sbjct: 2027 MDLVLELKNNASKLLLAIMESRHDSENAERILYNMR-----PKELVEVIKKAY 2074



 Score =  754 bits (1947), Expect = 0.0
 Identities = 525/1628 (32%), Positives = 809/1628 (49%), Gaps = 42/1628 (2%)
 Frame = +1

Query: 3802 YPLIRQMLVRLTGMCYRKGDPKPDTMNQQ--LLKNMRVYEVVLEFISVPHDKKHDHDMMK 3975
            Y +++++L+RL+ +C ++         QQ  LL+NM  + VVLE + +P++K  D  M +
Sbjct: 1151 YRVVKEILLRLSKLCVQENTTGRRNRKQQQRLLRNMGAHSVVLELLQIPYEKTEDTRMQE 1210

Query: 3976 LITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELA 4155
            ++ ++HEFL++FC  N++NQ+ L+K I+        +     I E  T+  IF NN +L
Sbjct: 1211 IMKIAHEFLQNFCAGNQQNQALLHKHIN--------LFLTPGILEAVTMQHIFMNNFQLC 1262

Query: 4156 SNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQL 4335
            S + E ++ H    IE + RN  +++ LQ +V    + I+  Q+ V  E+  + ++V
Sbjct: 1263 SEINERVVQHFAHCIETHGRNVQYIKFLQTIVKAEGRYIKKCQDIVMAELVNSGEDVLVF 1322

Query: 4336 YVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQI 4515
            Y D ASF+ L  MM+ E+E      D    L YHI LV LLA+CT GKN  TE+KC S +
Sbjct: 1323 YNDRASFQTLVQMMRSERERM----DENSPLMYHIHLVELLAVCTEGKNVYTEIKCNSLL 1378

Query: 4516 PMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSL 4695
            P+D IVRVVT + C+ EVK  Y+  L HCY+DT+ EMK+ Y + ++  +  N L DI
Sbjct: 1379 PLDDIVRVVTHEDCVPEVKIAYINFLNHCYVDTEVEMKEIYTSNHMWKLFENFLVDI--C 1436

Query: 4696 RVEKLTGAET---ATLEHYICHTVTEVLIKFFEAPYS----ALQQAKVDVHHHKK--TFS 4848
            RV   T         LE Y+   V  ++  FF +P+S     LQ +K+ V H  +   F
Sbjct: 1437 RVCNSTSDRKHADIVLERYVTEIVMSIVNTFFSSPFSDQSTTLQASKLAVVHQTRQPVFV 1496

Query: 4849 EVLLEL--TYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTS 5022
            ++L  +   Y     L   K+S     V  CI+ L+  A+   I +P  L     +
Sbjct: 1497 QLLQAIFRVYHCNWLLPSQKAS-----VESCIRVLSDVAKSRTIAIPVDLDSQVNNLFLK 1551

Query: 5023 VRQKWQQAASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFK 5202
                 Q+ A S  W    +   R++++    R Y            N++     ++   +
Sbjct: 1552 SHNIVQKTAMS--WRMSVRNAARRDSVLTASRDY-----------RNIIERLQDIVSSLE 1598

Query: 5203 FYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLC 5382
              L PL  AE SVLV+VLH PELLFPE +  R +C  G  + KLI+H K L++  ++ LC
Sbjct: 1599 DRLRPLVQAELSVLVDVLHRPELLFPENTDARKKCESGQFICKLIRHTKLLLEENEEKLC 1658

Query: 5383 ARVLQTLCKMCDCTKQQLTHQGHRVYNSSVEKGXXXXXXXXXXYFGHHNNHHPPLDRQQS 5562
             +VLQTL +M    +               +KG          Y+G+      P  R++S
Sbjct: 1659 IKVLQTLREMMAKDR------------GFGDKGEALRVILVNRYYGNIR----PAGRRES 1702

Query: 5563 XXXXX-----------XXXXXXXXXXTWSQERDLYAIQCKLNDAGASDLVTDIIIMEPSR 5709
                                          E  L  +QC L+  GASDLV D+I+   S
Sbjct: 1703 LTSFGNGPLSGGSSGKSGGGSIGSGSLSRSEMSLSDVQCHLDKQGASDLVIDLIMNATSD 1762

Query: 5710 EIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRLKSDMMSC 5889
             +F ++I LA ALL  GN  +QHSF+ R+ +    E FFK    R++ AQ  +
Sbjct: 1763 RVFHESILLAIALLEGGNTTIQHSFFCRLTEDKKSEKFFKVFFDRMKVAQQEI------- 1815

Query: 5890 SDSKPKVSSTVLTPLIDAGDTGFNGALFEVP--QQVRHPSISEMSQLSNDLTH-SIPDLA 6060
                 K + TV T  + +       +  E P  Q+VR PS     +    L   S+
Sbjct: 1816 -----KATVTVNTSDLGSKKRDEEQSERETPHHQRVREPSGQITEEAKEQLIEASVATKK 1870

Query: 6061 PYQDEEKSTDALPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFL 6240
             Y    +  D      +L E ++ V +   +  + L  + +          ++   L FL
Sbjct: 1871 AYYSFRREADP-DDHFSLGEGVMAVAE---KGRDELEMSAVI--------TIMQPILRFL 1918

Query: 6241 DTVCGSTKGSLGVF--GEIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQENGLNIII 6414
              +C +    L  F   +  + N++L+ +TL  L   C G        + +  N  N+
Sbjct: 1919 QLLCENHNRDLQNFLRCQNNKSNYNLVCETLQFLDCIC-GSTTGGLGLLGLYINEKNV-- 1975

Query: 6415 SLVLNEIKPLADDHMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLV 6594
            +L+   ++ L +       +     ++  +A  ES         +L ++  +      LV
Sbjct: 1976 ALINQTLESLTE-----YCQGPCHENQNCIATHESNGIDIITALILNDINPLGRKRMDLV 2030

Query: 6595 HAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSI 6774
                   E+ N+   +L +I        E     ++  +I  N      + V     +
Sbjct: 2031 ------LELKNNASKLLLAIM-------ESRHDSENAERILYNMRPKELVEVIKKAYLQG 2077

Query: 6775 HTEKNISSSLDDKFNDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLD-GSDEKKDDL 6951
              E     S +D        +  PR VGHNIYILAHQLA H+ EL+  L  G    + D
Sbjct: 2078 EVEFEDGESGEDY-------AASPRNVGHNIYILAHQLARHNKELQHMLKPGVQTGEGD- 2129

Query: 6952 TREALNYYKERTAQIEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVT 7131
              EAL +Y + TAQIEIVR DRT+E++VFP+  IC +LTK++K  +Y  TERD QGSK+
Sbjct: 2130 --EALEFYAKHTAQIEIVRLDRTMEQIVFPVPSICEFLTKESKLRIYYTTERDEQGSKIH 2187

Query: 7132 EFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPE-H 7308
            +FF   E +++EM WQ+KL+ ++ L WC+  +  W+ +SF+ A ++N LVA +YP    H
Sbjct: 2188 DFFQRSEDLFNEMNWQKKLRAQQVLYWCSRNMTFWSSISFNLAVLMNLLVAFFYPFVNVH 2247

Query: 7309 SNSSISLGNLYSWFAVFSSFLLAHYLRHDKIYLHKTXXXXXXXXXXXXXX--XIGVTLTL 7482
              +  S  +   W A+  S  +        I L K                  IG+  TL
Sbjct: 2248 GGTLDSRLSGLLWTAMLVSLAIV-------IVLPKPHGIRALIASTILRLIFSIGLQPTL 2300

Query: 7483 YIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYC 7662
            ++ G   + NKI+ + +FV N+G   R    ++      Y L+YL IC +G+ VH   Y
Sbjct: 2301 FLLGAFNVCNKIIFLTSFVGNRGTFTRGYGAMVLDVEFLYHLLYLLICAMGVFVHEFFYS 2360

Query: 7663 ILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPV 7842
            +LLFD+++ EETL NVI SVTRN +SI+ T +LALIL+Y FSI+G+L+F+ DF LEVD +
Sbjct: 2361 LLLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSIVGYLFFKDDFILEVDRL 2420

Query: 7843 ENDSSATISSGIPS------ETC---PSEGCPGLQPSXXXXXXXXXXXXSCETLWMCILQ 7995
            +N++    + G  +      E C       C   + +            +CETL MCI+
Sbjct: 2421 QNETIFPENGGTMTSELLYPEVCRVGSDTNCTHEELAQVTEEEEEEKEHTCETLLMCIVT 2480

Query: 7996 TGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTXXXXXXXXXXXXXXXXXXDTFGDLR 8175
                GLR+GGG+GDVLR P+  E +F  RV YD+                   DTF DLR
Sbjct: 2481 VLSHGLRSGGGVGDVLRKPSKEEPLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFADLR 2540

Query: 8176 AEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLYYIVMLQIKDETEFT 8355
            +EK +KE++LK  CFICGL+R +FDN++ TFE H + EHN+WHYL++IV++++KD TE+T
Sbjct: 2541 SEKQKKEEVLKTTCFICGLERDKFDNKTATFEEHFKEEHNMWHYLFFIVLVKVKDSTEYT 2600

Query: 8356 GPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLLQMMTLMREIISQNE 8535
            GPESYVA+ +KDRNLDWFPRM+A+SL  S+ + +Q+E++ ++++L   M L+  +  Q
Sbjct: 2601 GPESYVAEMIKDRNLDWFPRMRAMSLVSSDSEGEQNELRNLQEKLESTMRLVTNLSGQLS 2660

Query: 8536 ESRAFMEQ 8559
            E +  M +
Sbjct: 2661 ELKDQMTE 2668


>gi|44888998|sp|P29993|IP3R_DROME Inositol 1,4,5-trisphosphate
            receptor (InsP3 receptor) (InsP3R)
          Length = 2838

 Score = 1123 bits (2904), Expect = 0.0
 Identities = 751/2233 (33%), Positives = 1140/2233 (50%), Gaps = 138/2233 (6%)
 Frame = +1

Query: 2275 EIEVGWA--PNFRKLVDIAEGAKSNSDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPER 2448
            EI + W   P  R + D+A        +A  L+YYRHQL+L S MC  +QYLA++
Sbjct: 763  EIHLKWTGQPTSRSMADLAS-CDGGELEAAILNYYRHQLNLFSNMCLNRQYLALN----- 816

Query: 2449 RLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLHLHVVRG--SPMSAIRHARLWWSI 2622
                +S +L  +L+L+CMSD  +PY+LR SF RLMLHLHV R    P++ +++ARLW  I
Sbjct: 817  ---ELSPRLDIDLILKCMSDETMPYELRASFCRLMLHLHVDRDPQEPVTPVKYARLWSEI 873

Query: 2623 PENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATVETYLMGLRNQSMEERQSVNSSKL 2802
            P  +++  Y+  + +   +    R      +  +A VE YL  +  +          +KL
Sbjct: 874  PSKMSIQDYDGKNQQPDQNKQACRAK---FNTTIAFVENYLCNVATKVWLFTDQ-EQNKL 929

Query: 2803 TYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINEGPATEQVPSHRAMVNAIRNMSKSMM 2982
            T+E+V LA+ L  F FYSF+DLL+LT+ LL+I++    T         ++++   + +
Sbjct: 930  TFEVVKLARDLIYFGFYSFSDLLRLTKTLLSILDCVSDTSSGEFASTDIDSVEEETNAEA 989

Query: 2983 RGGNKENSKDL---------------AKTPSVTAEE---AGRTKEGRALNVKTKLIVAEI 3108
             GG   +  D+                  P+++ ++     +  +   L + TKL + EI
Sbjct: 990  EGGVLRSIGDINTVMTSLALGSVGQAIAAPTISLQQRKSVSQLMKEYPLVMDTKLKIIEI 1049

Query: 3109 LQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASE--------------- 3243
            LQF++DVR DYRI+  LS FK  F   E  +   S   +++ + +
Sbjct: 1050 LQFILDVRLDYRISCLLSIFKREFDESEVAASAASNEASQQQSQQQEPQTPGSSNETDPL 1109

Query: 3244 ----------------------------------LYDAIYRSSGHELHLDGRDGQLLLAI 3321
                                              ++D   RS    L LDG+ G+  L +
Sbjct: 1110 DSAESVAAGAAAAAATTARQKNIDLESIGVQAEGIFDC-ERSDAANLDLDGQGGRTFLRV 1168

Query: 3322 LLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILK 3501
            LL + M DY PL S AL + FRHF+Q QE+L+  +QVQLLVS++DVE+Y+QI  DL IL+
Sbjct: 1169 LLHLIMHDYAPLVSGALHLLFRHFSQRQEVLQAFRQVQLLVSDSDVESYKQIKSDLDILR 1228

Query: 3502 NLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNE 3681
               EKSELWV+         K  DE   T                D+G    +L
Sbjct: 1229 QSVEKSELWVY-------KAKATDELGAT----------------DAGGDAVSLE----- 1260

Query: 3682 HYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGD 3861
                         N  L ++ RN+                Y  ++++L+R+   C
Sbjct: 1261 ------------YNAALSQEQRNE----------------YRKVKEILIRMNKFCVTASG 1292

Query: 3862 P----KPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKE 4029
            P    KP    Q+LL+N+ V+ VVL+ +  P+D+K D  M +L+ L+HEFL++FC  N++
Sbjct: 1293 PGSVVKPRKHEQRLLRNVGVHTVVLDLLQNPYDEKDDELMKELMCLAHEFLQNFCLGNQQ 1352

Query: 4030 NQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHN 4209
            NQ  L+  +         +     I E  T+ AIF++N  L + V ++++ H V  IE +
Sbjct: 1353 NQVLLHNHLD--------LFLNPGILEAKTVCAIFKDNLALCNEVTDKVVQHFVHCIEIH 1404

Query: 4210 SRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEK 4389
             R+  +L+ LQ +V   ++ I   Q+ V  E+  + ++V   Y D  SF     MM+ +
Sbjct: 1405 GRHVAYLQFLQTVVAAENQFIRRCQDMVMQELINSGEDVLVFYNDKGSFNHFVQMMQQQM 1464

Query: 4390 ESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEV 4569
                + SD    LKYH+ELV+LLA CT GKN  TE+KC + + +D IV ++    C+ EV
Sbjct: 1465 LGMEKLSDDS-PLKYHVELVKLLACCTMGKNVYTEIKCNNLLSLDDIVTIICHPLCMPEV 1523

Query: 4570 KTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILN-NLLEDIRSLRVEKLTGAETATLEHYI 4746
            K  Y+  L HCYIDT+ EMK+ Y + ++  +   + L DI  L +     A   TL+ Y+
Sbjct: 1524 KEAYVDFLNHCYIDTEVEMKEIYASGHMWSLFEKSFLVDINQL-ITNPAAASNKTLQAYV 1582

Query: 4747 CHTVTEVLIKFFEAPYS---ALQQAKVDVHHHKKTFSEVLLELTYLEKGKLRGSKSSRNW 4917
             + VT +L  FF +P+S   A+ Q++  +       +  + +  +L  G         +
Sbjct: 1583 LNGVTNLLGSFFASPFSDQSAIVQSRQLIFVQLLQAAHRITQCRWLSLG---------DR 1633

Query: 4918 YRVAECIKRLTKWAEEHNITLPATLAGP--QMSGQTSVRQKWQQAASSAKWIGIGKRLNR 5091
            + V  CI+ LT+ A+  +I LP  L      MS +T++  +      + KW+   K+
Sbjct: 1634 FNVENCIRTLTESAKMRSIALPPELEQQVATMSSKTAMLTR-----QTTKWLLASKQ--- 1685

Query: 5092 QNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPEL 5271
                 P +     ++ M    S  ++     ++   +  L P+  AE S+LV++L+  EL
Sbjct: 1686 -----PKYEAQQAASLMRWDRS--IIEGLQDIVSLLEDQLKPVVEAELSLLVDILYRSEL 1738

Query: 5272 LFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKQQLTHQGH 5451
            LFP G+  R +C  GG + KLI+H + L++ K++ +C +VL+TL +M
Sbjct: 1739 LFPAGTEARKRCESGGFIRKLIKHTEKLLEEKEERMCVKVLRTLREMM------------ 1786

Query: 5452 RVYNSSVEKGXXXXXXXXXXYFGHHNNHHPPLDRQQSXXXXXXXXXXXXXXXTWSQE--- 5622
             +  +  EKG          YF   +    P D                   T
Sbjct: 1787 AIDVNYGEKGDALRQTLLLRYFQTKSTPRLPEDEVPLLAAPLMDPAKQNHLVTHGPGAKY 1846

Query: 5623 -----RDLYAIQCKLNDAGASDLVTDIIIMEP-SREIFLKAIHLARALLHEGNDKVQHSF 5784
                 + L+ +Q  L+  GASDLV +++I    S  IF++A+ L  ALL  GN  +Q
Sbjct: 1847 LQRAGKTLHEMQNHLDREGASDLVVELVIKSVHSPNIFVEAVELGIALLEGGNPIIQKGM 1906

Query: 5785 YMRMKQKDIHEPFFKAILTRIQTAQNRLKS-------DMMSCSDSKPKVSSTVLTPLIDA 5943
            + +    D+++ FFK    +++ AQ  +KS       D+ + +    + ++  L  +
Sbjct: 1907 FQKFLSDDLNQAFFKVFFEKMKDAQQEIKSTVTVNTTDIAAKAHEHKQDTNLELDKIARK 1966

Query: 5944 GDTGFNGALF--EVPQQVRHPSISEMSQLSN-------------DLTHSIPD-----LAP 6063
                 NG +   E+ +++ +  ++      N              +   + D     L
Sbjct: 1967 HGLKSNGVVITEELKRELHNAGLATARAYGNARNIHSGEESSAISVNSPLEDILAEKLEK 2026

Query: 6064 YQDEEKSTDALPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLD 6243
            ++D     + L  +V +++PILR LQLLCENHN  +QN LR Q+++TN+NLVSETL FLD
Sbjct: 2027 HKDSRDQRNQLSNKVLVMQPILRFLQLLCENHNPDMQNLLRNQNNKTNNNLVSETLMFLD 2086

Query: 6244 TVCGSTKGSLGVFG-EIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQE-NGLNIIIS 6417
             +CGST G LG+ G  I EHN +LI QTL  LTE+CQGPCHENQN +A  E NGL+II +
Sbjct: 2087 CICGSTTGGLGLLGLYINEHNLALINQTLEALTEYCQGPCHENQNCIATHESNGLDIITA 2146

Query: 6418 LVLNEIKPLADDHMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVH 6597
            L+LN I PL ++ M+L LE+K+ ASKLLLAIMESR D ENA R+L NM      PKQLV
Sbjct: 2147 LILNNINPLGENRMDLVLELKNNASKLLLAIMESRGDSENAERILYNM-----NPKQLVE 2201

Query: 6598 AIKQAYEMTNSNHHMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIH 6777
               +AY               +L  + +D  +  +G
Sbjct: 2202 VACKAYHQ------------EELIDEQDDGDEPDAG------------------------ 2225

Query: 6778 TEKNISSSLDDKFNDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKK----D 6945
                         +DDD  +V PREVGHNIYIL HQLA H+ EL   L  S++ +    D
Sbjct: 2226 -------------SDDDDATVSPREVGHNIYILCHQLAQHNKELAGLLKASEDPQSASFD 2272

Query: 6946 DLTREALNYYKERTAQIEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSK 7125
              T +AL YY   TAQIEIVR DRTLE++VFPI +IC YLT DTK  + N  ERD+QGSK
Sbjct: 2273 AKTSQALMYYATHTAQIEIVRNDRTLEQIVFPIPEICEYLTTDTKIKILNTAERDDQGSK 2332

Query: 7126 VTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYP--- 7296
            + +FFD+ E M++EM WQ+KL+ +  L W +  + LW+ + F+   ++N +VA +YP
Sbjct: 2333 LADFFDKAEEMFNEMKWQKKLRSQPLLFWISSYMSLWSNILFNCVVVINMIVAFFYPFDN 2392

Query: 7297 -LPEHSNSSISLGNLYSWFAVFSSFLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVT 7473
             +PE S S ISL  L+    +FS  ++    R   I                    +G
Sbjct: 2393 TVPELS-SHISL--LFWIITIFSLVIVLALPRESGI------RTFIGSVILRFIFLLGPE 2443

Query: 7474 LTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPM 7653
             TL + G++ +  K VH+V+ + NKG  ++ + +I+    L Y  +Y+  C  GL+ HP
Sbjct: 2444 STLCLLGVVTVTLKSVHIVSIMGNKGTLEKQLIKIITDFQLLYHCIYIAFCFCGLIFHPF 2503

Query: 7654 IYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEV 7833
             Y +LLFD+++ EETL NVI SVTRN +SIV T +LALIL+Y FSI+G+++F+ DF + V
Sbjct: 2504 FYSLLLFDVVYREETLVNVIRSVTRNGRSIVLTAVLALILVYLFSIIGYMFFKDDFLVSV 2563

Query: 7834 DPVENDSSA------TISSGIPSETCPSEGCPG-----LQPSXXXXXXXXXXXXSCETLW 7980
            D  E D++       T+S  +  ++C +    G      + +            SC++L
Sbjct: 2564 DFEEQDNAPPPSVPLTLSVPVSGDSCSAPDDLGNCQAAKEVAPPSAGGGEVKERSCDSLV 2623

Query: 7981 MCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTXXXXXXXXXXXXXXXXXXDT 8160
            MCI+ T  QGLRNGGGIGD+LR P+  E +F+ RV YD+                   DT
Sbjct: 2624 MCIVTTLNQGLRNGGGIGDILRAPSSKEGLFVARVIYDLLFFFIVIIIVLNLIFGVIIDT 2683

Query: 8161 FGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLYYIVMLQIKD 8340
            F DLR+EK +KE ILK  CFIC L+RS FDN++V+FE H ++EHN+WHYLY+IV++++KD
Sbjct: 2684 FADLRSEKQQKEAILKTTCFICSLNRSAFDNKTVSFEEHIKSEHNMWHYLYFIVLVKVKD 2743

Query: 8341 ETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLLQMMTLMREI 8520
             TEFTGPESYV   VK   L+WFPR++A+SL   + D +Q E++ M+ QLL    L++ +
Sbjct: 2744 PTEFTGPESYVYAMVKAGILEWFPRLRAMSLAAVDADGEQIELRSMQAQLLDTQLLIKNL 2803

Query: 8521 ISQNEESRAFMEQ 8559
             +Q  E +  M +
Sbjct: 2804 STQLHELKDHMTE 2816



 Score =  540 bits (1391), Expect = e-151
 Identities = 321/734 (43%), Positives = 443/734 (59%), Gaps = 10/734 (1%)
 Frame = +1

Query: 94   GNNGNLHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFK 273
            G+   LH+GDI+SLY E S      GFLSTLGLVDDR +V  + G    PPKKFRDCL K
Sbjct: 7    GSASFLHLGDIVSLYAEGSVC----GFLSTLGLVDDRTVVCPEAGDLSCPPKKFRDCLIK 62

Query: 274  VCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQY 453
            +CP+NRY+AQK  W   K  Q+  S  D +L+ +L  AA+ E+++NE+E +K LG  IQY
Sbjct: 63   ICPMNRYSAQKQFWKAAK--QSASSNTDPNLLKRLHHAAEIEKKQNETENKKLLGTSIQY 120

Query: 454  G-SMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNV 630
            G ++VQLLH+KSNKY+TV K  P+  E+NAM+VYLD  GNEGSWF I+P YK  +IGD V
Sbjct: 121  GRAVVQLLHLKSNKYLTVNKRLPSLLEKNAMRVYLDANGNEGSWFYIKPFYKLRSIGDYV 180

Query: 631  SA-GNKISLIPNSVSTTQAGHVKSQLHLSS-FNLLDHQSAAEVNCLNEPTEWQVFMFLLF 804
               G+K+ L P +         +  LH+++ + L D+    EVN LN  T W++ +F+
Sbjct: 181  VVVGDKVILSPVNAD-------QQNLHVAANYELPDNPGCKEVNVLNSSTSWKISLFMEH 233

Query: 805  DENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALW 984
             ENQ++ +K GDVVRLFHA+Q+ FLT+D   KQ      VFLR T R SA  ATSS+ALW
Sbjct: 234  KENQEHILKGGDVVRLFHAEQEKFLTMDEYKKQYH----VFLRTTGRTSATAATSSKALW 289

Query: 985  EVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRPPLLSALSQKSR 1164
            E++VVQ ++ RGG   WN  YRFKHLAT  YL+AE +++ V          +SA S
Sbjct: 290  EIEVVQHDSCRGGAGDWNSLYRFKHLATGHYLAAE-AEIDVSAGA------MSATSASGH 342

Query: 1165 PM-LERTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANLLFQLDPS 1341
             + L   +    +     N   N+     Q  + SV    P  ++        +F LD +
Sbjct: 343  DLHLGDCSKDSGLSCSTMNSTINDKPKGKQYRLVSV----PYSADIAS-----VFVLDAT 393

Query: 1342 TFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWVKVIC-EKNRVDK 1518
            T  + +  VP+ SYVRL H  S+ WVHAT+      +   + ++K  + ++C    + DK
Sbjct: 394  TMARPDSLVPQSSYVRLQHICSNTWVHATS------IPIDADDDKPVMSMVCCSPIKEDK 447

Query: 1519 ETFALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTN 1698
            E FAL+PV+P EVRDLDFANDACK L      +  G +   E   +   LL D + F+
Sbjct: 448  EAFALIPVSPVEVRDLDFANDACKVLATVTSKLDNGSISINER-RALISLLQDIVYFIAG 506

Query: 1699 --SSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXX 1872
              +  +    L+ +  +P RDRQKLLREQ +L Q+F +L+ PF   Q  T
Sbjct: 507  MENEQNKTKALEFTIKNPIRDRQKLLREQYILKQLFKILQGPF---QEHTAGDGPFLRLD 563

Query: 1873 XXXDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVL 2052
               D +N  +K +F+LCY +L+ SQ  YRKNQE++A+ FG +Q+QIG+D++AEDT+TA+L
Sbjct: 564  ELSDPKNSPYKNIFRLCYRILRLSQQDYRKNQEYIAKHFGLMQKQIGYDILAEDTITALL 623

Query: 2053 HNNPKLLEKYVKTPHVERFVELVRNNR---QGKFLDYLADLCVCRGEANKKIQELICTSV 2223
            HNN KLLEK++    +E FV LVR N      +FLDYL+DLCV   +A    QELIC SV
Sbjct: 624  HNNRKLLEKHITAAEIETFVGLVRKNMHNWDSRFLDYLSDLCVSNRKAIAVTQELICKSV 683

Query: 2224 LSSKHRDIFMDTKI 2265
            LS K++DI ++T++
Sbjct: 684  LSDKNKDILIETQV 697


>gi|24644261|ref|NP_730942.1| CG1063-PA [Drosophila melanogaster]
 gi|23170366|gb|AAF52015.2| CG1063-PA [Drosophila melanogaster]
          Length = 2828

 Score = 1122 bits (2903), Expect = 0.0
 Identities = 754/2225 (33%), Positives = 1144/2225 (50%), Gaps = 130/2225 (5%)
 Frame = +1

Query: 2275 EIEVGWA--PNFRKLVDIAEGAKSNSDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPER 2448
            EI + W   P  R + D+A        +A  L+YYRHQL+L S MC  +QYLA++
Sbjct: 762  EIHLKWTGQPTSRSMADLAS-CDGGELEAAILNYYRHQLNLFSNMCLNRQYLALN----- 815

Query: 2449 RLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLHLHVVRG--SPMSAIRHARLWWSI 2622
                +S +L  +L+L+CMSD  +PY+LR SF RLMLHLHV R    P++ +++ARLW  I
Sbjct: 816  ---ELSPRLDIDLILKCMSDETMPYELRASFCRLMLHLHVDRDPQEPVTPVKYARLWSEI 872

Query: 2623 PENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATVETYLMGLRNQSMEERQSVNSSKL 2802
            P  +++  Y+  + +   +    R      +  +A VE YL  +  +          +KL
Sbjct: 873  PSKMSIQDYDGKNQQPDQNKQACRAK---FNTTIAFVENYLCNVATKVWLFTDQ-EQNKL 928

Query: 2803 TYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIIN------EGP-ATEQVPSHRAMVNAIR 2961
            T+E+V LA+ L  F FYSF+DLL+LT+ LL+I++       G  A+  + S   ++ +I
Sbjct: 929  TFEVVKLARDLIYFGFYSFSDLLRLTKTLLSILDCVSDTSSGEFASTDIDSEGGVLRSIG 988

Query: 2962 NMSKSMMRGGNKENSKDLAKTPSVTAEE---AGRTKEGRALNVKTKLIVAEILQFVMDVR 3132
            +++  M         + +A  P+++ ++     +  +   L + TKL + EILQF++DVR
Sbjct: 989  DINTVMTSLALGSVGQAIA-APTISLQQRKSVSQLMKEYPLVMDTKLKIIEILQFILDVR 1047

Query: 3133 RDYRITMALSWFKNVFPCDEDGSLMHSASINERMASE----------------------- 3243
             DYRI+  LS FK  F   E  +   S   +++ + +
Sbjct: 1048 LDYRISCLLSIFKREFDESEVAASAASNEASQQQSQQQEPQTPGSSNETDPLDSAESVAA 1107

Query: 3244 --------------------------LYDAIYRSSGHELHLDGRDGQLLLAILLQMTMSD 3345
                                      ++D   RS    L LDG+ G+  L +LL + M D
Sbjct: 1108 GAAAAAATTARQKNIDLESIGVQAEGIFDC-ERSDAANLDLDGQGGRTFLRVLLHLIMHD 1166

Query: 3346 YPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSEL 3525
            Y PL S AL + FRHF+Q QE+L+  +QVQLLVS++DVE+Y+QI  DL IL+   EKSEL
Sbjct: 1167 YAPLVSGALHLLFRHFSQRQEVLQAFRQVQLLVSDSDVESYKQIKSDLDILRQSVEKSEL 1226

Query: 3526 WVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNE 3705
            WV+         K  DE   T                D+G    +L
Sbjct: 1227 WVY-------KAKATDELGAT----------------DAGGDAVSLE------------- 1250

Query: 3706 CLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDP----KPD 3873
                 N  L ++ RN+                Y  ++++L+R+   C     P    KP
Sbjct: 1251 ----YNAALSQEQRNE----------------YRKVKEILIRMNKFCVTASGPGSVVKPR 1290

Query: 3874 TMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKF 4053
               Q+LL+N+ V+ VVL+ +  P+D+K D  M +L+ L+HEFL++FC  N++NQ  L+
Sbjct: 1291 KHEQRLLRNVGVHTVVLDLLQNPYDEKDDELMKELMCLAHEFLQNFCLGNQQNQVLLHNH 1350

Query: 4054 ISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLE 4233
            +         +     I E  T+ AIF++N  L + V ++++ H V  IE + R+  +L+
Sbjct: 1351 LD--------LFLNPGILEAKTVCAIFKDNLALCNEVTDKVVQHFVHCIEIHGRHVAYLQ 1402

Query: 4234 LLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSD 4413
             LQ +V   ++ I   Q+ V  E+  + ++V   Y D  SF     MM+ +     + SD
Sbjct: 1403 FLQTVVRAENQFIRRCQDMVMQELINSGEDVLVFYNDKGSFNHFVQMMQQQMLRMEKLSD 1462

Query: 4414 SRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLL 4593
                LKYH+ELV+LLA CT GKN  TE+KC + + +D IV ++    C+ EVK  Y+  L
Sbjct: 1463 DS-PLKYHVELVKLLACCTMGKNVYTEIKCNNLLSLDDIVTIICHPLCMPEVKEAYVDFL 1521

Query: 4594 LHCYIDTDAEMKDAYKTEYVDHILN-NLLEDIRSLRVEKLTGAETATLEHYICHTVTEVL 4770
             HCYIDT+ EMK+ Y + ++  +   + L DI  L +     A   TL+ Y+ + VT +L
Sbjct: 1522 NHCYIDTEVEMKEIYASGHMWSLFEKSFLVDINQL-ITNPAAASNKTLQAYVLNGVTNLL 1580

Query: 4771 IKFFEAPYS---ALQQAKVDVHHHKKTFSEVLLELTYLEKGKLRGSKSSRNWYRVAECIK 4941
              FF +P+S   A+ Q++  +       +  + +  +L  G         + + V  CI+
Sbjct: 1581 GSFFASPFSDQSAIVQSRQLIFVQLLQAAHRITQCRWLSLG---------DRFNVENCIR 1631

Query: 4942 RLTKWAEEHNITLPATLAGP--QMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGH 5115
             LT+ A+  +I LP  L      MS +T++  +      + KW+   K+        P +
Sbjct: 1632 TLTESAKMRSIALPPELEQQVATMSSKTAMLTR-----QTTKWLLASKQ--------PKY 1678

Query: 5116 RLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSAL 5295
                 ++ M    S  ++     ++   +  L P+  AE S+LV++L+  ELLFP G+
Sbjct: 1679 EAQQAASLMRWDRS--IIEGLQDIVSLLEDQLKPVVEAELSLLVDILYRSELLFPAGTEA 1736

Query: 5296 RDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKQQLTHQGHRVYNSSVE 5475
            R +C  GG + KLI+H + L++ K++ +C +VL+TL +M              +  +  E
Sbjct: 1737 RKRCESGGFIRKLIKHTEKLLEEKEERMCVKVLRTLREMM------------AIDVNYGE 1784

Query: 5476 KGXXXXXXXXXXYFGHHNNHHPPLDRQQSXXXXXXXXXXXXXXXTWSQE--------RDL 5631
            KG          YF   +    P D                   T            + L
Sbjct: 1785 KGDALRQTLLLRYFQTKSTPRLPEDEVPLLAAPLMDPAKQNHLVTHGPGAKYLQRAGKTL 1844

Query: 5632 YAIQCKLNDAGASDLVTDIIIMEP-SREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKD 5808
            + +Q  L+  GASDLV +++I    S  IF++A+ L  ALL  GN  +Q   + +    D
Sbjct: 1845 HEMQNHLDREGASDLVVELVIKSVHSPNIFVEAVELGIALLEGGNPIIQKGMFQKFLSDD 1904

Query: 5809 IHEPFFKAILTRIQTAQNRLKS-------DMMSCSDSKPKVSSTVLTPLIDAGDTGFNGA 5967
            +++ FFK    +++ AQ  +KS       D+ + +    + ++  L  +        NG
Sbjct: 1905 LNQAFFKVFFEKMKDAQQEIKSTVTVNTTDIAAKAHEHKQDTNLELDKIARKHGLKSNGV 1964

Query: 5968 LF--EVPQQVRHPSISEMSQLSN-------------DLTHSIPD-----LAPYQDEEKST 6087
            +   E+ +++ +  ++      N              +   + D     L  ++D
Sbjct: 1965 VITEELKRELHNAGLATARAYGNARNIHSGEESSAISVNSPLEDILAEKLEKHKDSRDQR 2024

Query: 6088 DALPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKG 6267
            + L  +V +++PILR LQLLCENHN  +QN LR Q+++TN+NLVSETL FLD +CGST G
Sbjct: 2025 NQLSNKVLVMQPILRFLQLLCENHNPDMQNLLRNQNNKTNNNLVSETLMFLDCICGSTTG 2084

Query: 6268 SLGVFG-EIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQE-NGLNIIISLVLNEIKP 6441
             LG+ G  I EHN +LI QTL  LTE+CQGPCHENQN +A  E NGL+II +L+LN I P
Sbjct: 2085 GLGLLGLYINEHNVALINQTLEALTEYCQGPCHENQNCIATHESNGLDIITALILNNINP 2144

Query: 6442 LADDHMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEM 6621
            L ++ M+L LE+K+ ASKLLLAIMESR D ENA R+L NM      PKQLV    +AY
Sbjct: 2145 LGENRMDLVLELKNNASKLLLAIMESRGDSENAERILYNM-----NPKQLVEVACKAYHQ 2199

Query: 6622 TNSNHHMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSS 6801
                         +L  + +D  +  +G
Sbjct: 2200 ------------EELIDEQDDGDEPDAG-------------------------------- 2215

Query: 6802 LDDKFNDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKK----DDLTREALN 6969
                 +DDD  +V PREVGHNIYIL HQLA H+ EL   L  S++ +    D  T +AL
Sbjct: 2216 -----SDDDDATVSPREVGHNIYILCHQLAQHNKELAGLLKASEDPQSASFDAKTSQALM 2270

Query: 6970 YYKERTAQIEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEW 7149
            YY   TAQIEIVR DRTLE++VFPI +IC YLT DTK  + N  ERD+QGSKV +FFD+
Sbjct: 2271 YYATHTAQIEIVRNDRTLEQIVFPIPEICEYLTTDTKIKILNTAERDDQGSKVADFFDKA 2330

Query: 7150 ETMYHEMIWQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYP----LPEHSNS 7317
            E M++EM WQ+KL+ +  L W +  + LW+ + F+   ++N +VA +YP    +PE S S
Sbjct: 2331 EEMFNEMKWQKKLRSQPLLFWISSYMSLWSNILFNCVVVINMIVAFFYPFDNTVPELS-S 2389

Query: 7318 SISLGNLYSWFAVFSSFLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGI 7497
             ISL  L+    +FS  ++    R   I                    +G   TL + G+
Sbjct: 2390 HISL--LFWIITIFSLVIVLALPRESGI------RTFIGSVILRFIFLLGPESTLCLLGV 2441

Query: 7498 LQLVNKIVHVVAFVSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFD 7677
            + +  K VH+V+ + NKG  ++ + +I+    L Y  +Y+  C  GL+ HP  Y +LLFD
Sbjct: 2442 VTVTLKSVHIVSIMGNKGTLEKQLIKIITDFQLLYHCIYIAFCFCGLIFHPFFYSLLLFD 2501

Query: 7678 IIFTEETLQNVIASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSS 7857
            +++ EETL NVI SVTRN +SIV T +LALIL+Y FSI+G+++F+ DF + VD  E D++
Sbjct: 2502 VVYREETLVNVIRSVTRNGRSIVLTAVLALILVYLFSIIGYMFFKDDFLVSVDFEEQDNA 2561

Query: 7858 A------TISSGIPSETCPSEGCPG-----LQPSXXXXXXXXXXXXSCETLWMCILQTGY 8004
                   T+S  +  ++C +    G      + +            SC++L MCI+ T
Sbjct: 2562 PPPSVPLTLSVPVSGDSCSAPDDLGNCQAAKEVAPPSAGGGEVKERSCDSLVMCIVTTLN 2621

Query: 8005 QGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTXXXXXXXXXXXXXXXXXXDTFGDLRAEK 8184
            QGLRNGGGIGD+LR P+  E +F+ RV YD+                   DTF DLR+EK
Sbjct: 2622 QGLRNGGGIGDILRAPSSKEGLFVARVIYDLLFFFIVIIIVLNLIFGVIIDTFADLRSEK 2681

Query: 8185 NEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPE 8364
             +KE ILK  CFIC L+RS FDN++V+FE H ++EHN+WHYLY+IV++++KD TEFTGPE
Sbjct: 2682 QQKEAILKTTCFICSLNRSAFDNKTVSFEEHIKSEHNMWHYLYFIVLVKVKDPTEFTGPE 2741

Query: 8365 SYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLLQMMTLMREIISQNEESR 8544
            SYV   VK   L+WFPR++A+SL   + D +Q E++ M+ QLL    L++ + +Q  E +
Sbjct: 2742 SYVYAMVKAGILEWFPRLRAMSLAAVDADGEQIELRSMQAQLLDTQLLIKNLSTQLHELK 2801

Query: 8545 AFMEQ 8559
              M +
Sbjct: 2802 DHMTE 2806



 Score =  545 bits (1403), Expect = e-152
 Identities = 321/733 (43%), Positives = 443/733 (59%), Gaps = 9/733 (1%)
 Frame = +1

Query: 94   GNNGNLHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFK 273
            G+   LH+GDI+SLY E S      GFLSTLGLVDDR +V  + G    PPKKFRDCL K
Sbjct: 7    GSASFLHLGDIVSLYAEGSVC----GFLSTLGLVDDRTVVCPEAGDLSCPPKKFRDCLIK 62

Query: 274  VCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQY 453
            +CP+NRY+AQK  W   K  Q+  S  D +L+ +L  AA+ E+++NE+E +K LG  IQY
Sbjct: 63   ICPMNRYSAQKQFWKAAK--QSASSNTDPNLLKRLHHAAEIEKKQNETENKKLLGTSIQY 120

Query: 454  G-SMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNV 630
            G ++VQLLH+KSNKY+TV K  P+  E+NAM+VYLD  GNEGSWF I+P YK  +IGD V
Sbjct: 121  GRAVVQLLHLKSNKYLTVNKRLPSLLEKNAMRVYLDANGNEGSWFYIKPFYKLRSIGDYV 180

Query: 631  SAGNKISLIPNSVSTTQAGHVKSQLHLSS-FNLLDHQSAAEVNCLNEPTEWQVFMFLLFD 807
              G+K+ L P +         +  LH+++ + L D+    EVN LN  T W++ +F+
Sbjct: 181  VVGDKVILSPVNAD-------QQNLHVAANYELPDNPGCKEVNVLNSSTSWKISLFMEHK 233

Query: 808  ENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWE 987
            ENQ++ +K GDVVRLFHA+Q+ FLT+D   KQ      VFLR T R SA  ATSS+ALWE
Sbjct: 234  ENQEHILKGGDVVRLFHAEQEKFLTMDEYKKQYH----VFLRTTGRTSATAATSSKALWE 289

Query: 988  VQVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRPPLLSALSQKSRP 1167
            ++VVQ ++ RGG   WN  YRFKHLAT  YL+AE +++ V          +SA S
Sbjct: 290  IEVVQHDSCRGGAGDWNSLYRFKHLATGHYLAAE-AEIDVSAGA------MSATSASGHD 342

Query: 1168 M-LERTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANLLFQLDPST 1344
            + L   +    +     N   N+     Q  + SV    P  ++        +F LD +T
Sbjct: 343  LHLGDCSKDSGLSCSTMNSTINDKPKGKQYRLVSV----PYSADIAS-----VFVLDATT 393

Query: 1345 FMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWVKVIC-EKNRVDKE 1521
              + +  VP+ SYVRL H  S+ WVHAT+      +   + ++K  + ++C    + DKE
Sbjct: 394  MARPDSLVPQSSYVRLQHICSNTWVHATS------IPIDADDDKPVMSMVCCSPIKEDKE 447

Query: 1522 TFALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTN- 1698
             FAL+PV+P EVRDLDFANDACK L      +  G +   E   +   LL D + F+
Sbjct: 448  AFALIPVSPVEVRDLDFANDACKVLATVTSKLDNGSISINER-RALISLLQDIVYFIAGM 506

Query: 1699 -SSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXX 1875
             +  +    L+ +  +P RDRQKLLREQ +L Q+F +L+ PF   Q  T
Sbjct: 507  ENEQNKTKALEFTIKNPIRDRQKLLREQYILKQLFKILQGPF---QQHTAGDGPFLRLDE 563

Query: 1876 XXDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLH 2055
              D +N  +K +F+LCY +L+ SQ  YRKNQE++A+ FG +Q+QIG+D++AEDT+TA+LH
Sbjct: 564  LSDPKNSPYKNIFRLCYRILRLSQQDYRKNQEYIAKHFGLMQKQIGYDILAEDTITALLH 623

Query: 2056 NNPKLLEKYVKTPHVERFVELVRNNR---QGKFLDYLADLCVCRGEANKKIQELICTSVL 2226
            NN KLLEK++    +E FV LVR N      +FLDYL+DLCV   +A    QELIC SVL
Sbjct: 624  NNRKLLEKHITAAEIETFVGLVRKNMHNWDSRFLDYLSDLCVSNRKAIAVTQELICKSVL 683

Query: 2227 SSKHRDIFMDTKI 2265
            S K++DI ++T++
Sbjct: 684  SDKNKDILIETQV 696


>gi|24644259|ref|NP_730941.1| CG1063-PB [Drosophila melanogaster]
 gi|23170365|gb|AAN13240.1| CG1063-PB [Drosophila melanogaster]
          Length = 2837

 Score = 1122 bits (2902), Expect = 0.0
 Identities = 752/2233 (33%), Positives = 1140/2233 (50%), Gaps = 138/2233 (6%)
 Frame = +1

Query: 2275 EIEVGWA--PNFRKLVDIAEGAKSNSDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPER 2448
            EI + W   P  R + D+A        +A  L+YYRHQL+L S MC  +QYLA++
Sbjct: 762  EIHLKWTGQPTSRSMADLAS-CDGGELEAAILNYYRHQLNLFSNMCLNRQYLALN----- 815

Query: 2449 RLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLHLHVVRG--SPMSAIRHARLWWSI 2622
                +S +L  +L+L+CMSD  +PY+LR SF RLMLHLHV R    P++ +++ARLW  I
Sbjct: 816  ---ELSPRLDIDLILKCMSDETMPYELRASFCRLMLHLHVDRDPQEPVTPVKYARLWSEI 872

Query: 2623 PENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATVETYLMGLRNQSMEERQSVNSSKL 2802
            P  +++  Y+  + +   +    R      +  +A VE YL  +  +          +KL
Sbjct: 873  PSKMSIQDYDGKNQQPDQNKQACRAK---FNTTIAFVENYLCNVATKVWLFTDQ-EQNKL 928

Query: 2803 TYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINEGPATEQVPSHRAMVNAIRNMSKSMM 2982
            T+E+V LA+ L  F FYSF+DLL+LT+ LL+I++    T         ++++   + +
Sbjct: 929  TFEVVKLARDLIYFGFYSFSDLLRLTKTLLSILDCVSDTSSGEFASTDIDSVEEETNAEA 988

Query: 2983 RGGNKENSKDL---------------AKTPSVTAEE---AGRTKEGRALNVKTKLIVAEI 3108
             GG   +  D+                  P+++ ++     +  +   L + TKL + EI
Sbjct: 989  EGGVLRSIGDINTVMTSLALGSVGQAIAAPTISLQQRKSVSQLMKEYPLVMDTKLKIIEI 1048

Query: 3109 LQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASE--------------- 3243
            LQF++DVR DYRI+  LS FK  F   E  +   S   +++ + +
Sbjct: 1049 LQFILDVRLDYRISCLLSIFKREFDESEVAASAASNEASQQQSQQQEPQTPGSSNETDPL 1108

Query: 3244 ----------------------------------LYDAIYRSSGHELHLDGRDGQLLLAI 3321
                                              ++D   RS    L LDG+ G+  L +
Sbjct: 1109 DSAESVAAGAAAAAATTARQKNIDLESIGVQAEGIFDC-ERSDAANLDLDGQGGRTFLRV 1167

Query: 3322 LLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILK 3501
            LL + M DY PL S AL + FRHF+Q QE+L+  +QVQLLVS++DVE+Y+QI  DL IL+
Sbjct: 1168 LLHLIMHDYAPLVSGALHLLFRHFSQRQEVLQAFRQVQLLVSDSDVESYKQIKSDLDILR 1227

Query: 3502 NLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNE 3681
               EKSELWV+         K  DE   T                D+G    +L
Sbjct: 1228 QSVEKSELWVY-------KAKATDELGAT----------------DAGGDAVSLE----- 1259

Query: 3682 HYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGD 3861
                         N  L ++ RN+                Y  ++++L+R+   C
Sbjct: 1260 ------------YNAALSQEQRNE----------------YRKVKEILIRMNKFCVTASG 1291

Query: 3862 P----KPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKE 4029
            P    KP    Q+LL+N+ V+ VVL+ +  P+D+K D  M +L+ L+HEFL++FC  N++
Sbjct: 1292 PGSVVKPRKHEQRLLRNVGVHTVVLDLLQNPYDEKDDELMKELMCLAHEFLQNFCLGNQQ 1351

Query: 4030 NQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHN 4209
            NQ  L+  +         +     I E  T+ AIF++N  L + V ++++ H V  IE +
Sbjct: 1352 NQVLLHNHLD--------LFLNPGILEAKTVCAIFKDNLALCNEVTDKVVQHFVHCIEIH 1403

Query: 4210 SRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEK 4389
             R+  +L+ LQ +V   ++ I   Q+ V  E+  + ++V   Y D  SF     MM+ +
Sbjct: 1404 GRHVAYLQFLQTVVRAENQFIRRCQDMVMQELINSGEDVLVFYNDKGSFNHFVQMMQQQM 1463

Query: 4390 ESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEV 4569
                + SD    LKYH+ELV+LLA CT GKN  TE+KC + + +D IV ++    C+ EV
Sbjct: 1464 LRMEKLSDDS-PLKYHVELVKLLACCTMGKNVYTEIKCNNLLSLDDIVTIICHPLCMPEV 1522

Query: 4570 KTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILN-NLLEDIRSLRVEKLTGAETATLEHYI 4746
            K  Y+  L HCYIDT+ EMK+ Y + ++  +   + L DI  L +     A   TL+ Y+
Sbjct: 1523 KEAYVDFLNHCYIDTEVEMKEIYASGHMWSLFEKSFLVDINQL-ITNPAAASNKTLQAYV 1581

Query: 4747 CHTVTEVLIKFFEAPYS---ALQQAKVDVHHHKKTFSEVLLELTYLEKGKLRGSKSSRNW 4917
             + VT +L  FF +P+S   A+ Q++  +       +  + +  +L  G         +
Sbjct: 1582 LNGVTNLLGSFFASPFSDQSAIVQSRQLIFVQLLQAAHRITQCRWLSLG---------DR 1632

Query: 4918 YRVAECIKRLTKWAEEHNITLPATLAGP--QMSGQTSVRQKWQQAASSAKWIGIGKRLNR 5091
            + V  CI+ LT+ A+  +I LP  L      MS +T++  +      + KW+   K+
Sbjct: 1633 FNVENCIRTLTESAKMRSIALPPELEQQVATMSSKTAMLTR-----QTTKWLLASKQ--- 1684

Query: 5092 QNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPEL 5271
                 P +     ++ M    S  ++     ++   +  L P+  AE S+LV++L+  EL
Sbjct: 1685 -----PKYEAQQAASLMRWDRS--IIEGLQDIVSLLEDQLKPVVEAELSLLVDILYRSEL 1737

Query: 5272 LFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKQQLTHQGH 5451
            LFP G+  R +C  GG + KLI+H + L++ K++ +C +VL+TL +M
Sbjct: 1738 LFPAGTEARKRCESGGFIRKLIKHTEKLLEEKEERMCVKVLRTLREMM------------ 1785

Query: 5452 RVYNSSVEKGXXXXXXXXXXYFGHHNNHHPPLDRQQSXXXXXXXXXXXXXXXTWSQE--- 5622
             +  +  EKG          YF   +    P D                   T
Sbjct: 1786 AIDVNYGEKGDALRQTLLLRYFQTKSTPRLPEDEVPLLAAPLMDPAKQNHLVTHGPGAKY 1845

Query: 5623 -----RDLYAIQCKLNDAGASDLVTDIIIMEP-SREIFLKAIHLARALLHEGNDKVQHSF 5784
                 + L+ +Q  L+  GASDLV +++I    S  IF++A+ L  ALL  GN  +Q
Sbjct: 1846 LQRAGKTLHEMQNHLDREGASDLVVELVIKSVHSPNIFVEAVELGIALLEGGNPIIQKGM 1905

Query: 5785 YMRMKQKDIHEPFFKAILTRIQTAQNRLKS-------DMMSCSDSKPKVSSTVLTPLIDA 5943
            + +    D+++ FFK    +++ AQ  +KS       D+ + +    + ++  L  +
Sbjct: 1906 FQKFLSDDLNQAFFKVFFEKMKDAQQEIKSTVTVNTTDIAAKAHEHKQDTNLELDKIARK 1965

Query: 5944 GDTGFNGALF--EVPQQVRHPSISEMSQLSN-------------DLTHSIPD-----LAP 6063
                 NG +   E+ +++ +  ++      N              +   + D     L
Sbjct: 1966 HGLKSNGVVITEELKRELHNAGLATARAYGNARNIHSGEESSAISVNSPLEDILAEKLEK 2025

Query: 6064 YQDEEKSTDALPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLD 6243
            ++D     + L  +V +++PILR LQLLCENHN  +QN LR Q+++TN+NLVSETL FLD
Sbjct: 2026 HKDSRDQRNQLSNKVLVMQPILRFLQLLCENHNPDMQNLLRNQNNKTNNNLVSETLMFLD 2085

Query: 6244 TVCGSTKGSLGVFG-EIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQE-NGLNIIIS 6417
             +CGST G LG+ G  I EHN +LI QTL  LTE+CQGPCHENQN +A  E NGL+II +
Sbjct: 2086 CICGSTTGGLGLLGLYINEHNVALINQTLEALTEYCQGPCHENQNCIATHESNGLDIITA 2145

Query: 6418 LVLNEIKPLADDHMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVH 6597
            L+LN I PL ++ M+L LE+K+ ASKLLLAIMESR D ENA R+L NM      PKQLV
Sbjct: 2146 LILNNINPLGENRMDLVLELKNNASKLLLAIMESRGDSENAERILYNM-----NPKQLVE 2200

Query: 6598 AIKQAYEMTNSNHHMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIH 6777
               +AY               +L  + +D  +  +G
Sbjct: 2201 VACKAYHQ------------EELIDEQDDGDEPDAG------------------------ 2224

Query: 6778 TEKNISSSLDDKFNDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKK----D 6945
                         +DDD  +V PREVGHNIYIL HQLA H+ EL   L  S++ +    D
Sbjct: 2225 -------------SDDDDATVSPREVGHNIYILCHQLAQHNKELAGLLKASEDPQSASFD 2271

Query: 6946 DLTREALNYYKERTAQIEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSK 7125
              T +AL YY   TAQIEIVR DRTLE++VFPI +IC YLT DTK  + N  ERD+QGSK
Sbjct: 2272 AKTSQALMYYATHTAQIEIVRNDRTLEQIVFPIPEICEYLTTDTKIKILNTAERDDQGSK 2331

Query: 7126 VTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYP--- 7296
            V +FFD+ E M++EM WQ+KL+ +  L W +  + LW+ + F+   ++N +VA +YP
Sbjct: 2332 VADFFDKAEEMFNEMKWQKKLRSQPLLFWISSYMSLWSNILFNCVVVINMIVAFFYPFDN 2391

Query: 7297 -LPEHSNSSISLGNLYSWFAVFSSFLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVT 7473
             +PE S S ISL  L+    +FS  ++    R   I                    +G
Sbjct: 2392 TVPELS-SHISL--LFWIITIFSLVIVLALPRESGI------RTFIGSVILRFIFLLGPE 2442

Query: 7474 LTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPM 7653
             TL + G++ +  K VH+V+ + NKG  ++ + +I+    L Y  +Y+  C  GL+ HP
Sbjct: 2443 STLCLLGVVTVTLKSVHIVSIMGNKGTLEKQLIKIITDFQLLYHCIYIAFCFCGLIFHPF 2502

Query: 7654 IYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEV 7833
             Y +LLFD+++ EETL NVI SVTRN +SIV T +LALIL+Y FSI+G+++F+ DF + V
Sbjct: 2503 FYSLLLFDVVYREETLVNVIRSVTRNGRSIVLTAVLALILVYLFSIIGYMFFKDDFLVSV 2562

Query: 7834 DPVENDSSA------TISSGIPSETCPSEGCPG-----LQPSXXXXXXXXXXXXSCETLW 7980
            D  E D++       T+S  +  ++C +    G      + +            SC++L
Sbjct: 2563 DFEEQDNAPPPSVPLTLSVPVSGDSCSAPDDLGNCQAAKEVAPPSAGGGEVKERSCDSLV 2622

Query: 7981 MCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTXXXXXXXXXXXXXXXXXXDT 8160
            MCI+ T  QGLRNGGGIGD+LR P+  E +F+ RV YD+                   DT
Sbjct: 2623 MCIVTTLNQGLRNGGGIGDILRAPSSKEGLFVARVIYDLLFFFIVIIIVLNLIFGVIIDT 2682

Query: 8161 FGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLYYIVMLQIKD 8340
            F DLR+EK +KE ILK  CFIC L+RS FDN++V+FE H ++EHN+WHYLY+IV++++KD
Sbjct: 2683 FADLRSEKQQKEAILKTTCFICSLNRSAFDNKTVSFEEHIKSEHNMWHYLYFIVLVKVKD 2742

Query: 8341 ETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLLQMMTLMREI 8520
             TEFTGPESYV   VK   L+WFPR++A+SL   + D +Q E++ M+ QLL    L++ +
Sbjct: 2743 PTEFTGPESYVYAMVKAGILEWFPRLRAMSLAAVDADGEQIELRSMQAQLLDTQLLIKNL 2802

Query: 8521 ISQNEESRAFMEQ 8559
             +Q  E +  M +
Sbjct: 2803 STQLHELKDHMTE 2815



 Score =  545 bits (1403), Expect = e-152
 Identities = 321/733 (43%), Positives = 443/733 (59%), Gaps = 9/733 (1%)
 Frame = +1

Query: 94   GNNGNLHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFK 273
            G+   LH+GDI+SLY E S      GFLSTLGLVDDR +V  + G    PPKKFRDCL K
Sbjct: 7    GSASFLHLGDIVSLYAEGSVC----GFLSTLGLVDDRTVVCPEAGDLSCPPKKFRDCLIK 62

Query: 274  VCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQY 453
            +CP+NRY+AQK  W   K  Q+  S  D +L+ +L  AA+ E+++NE+E +K LG  IQY
Sbjct: 63   ICPMNRYSAQKQFWKAAK--QSASSNTDPNLLKRLHHAAEIEKKQNETENKKLLGTSIQY 120

Query: 454  G-SMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNV 630
            G ++VQLLH+KSNKY+TV K  P+  E+NAM+VYLD  GNEGSWF I+P YK  +IGD V
Sbjct: 121  GRAVVQLLHLKSNKYLTVNKRLPSLLEKNAMRVYLDANGNEGSWFYIKPFYKLRSIGDYV 180

Query: 631  SAGNKISLIPNSVSTTQAGHVKSQLHLSS-FNLLDHQSAAEVNCLNEPTEWQVFMFLLFD 807
              G+K+ L P +         +  LH+++ + L D+    EVN LN  T W++ +F+
Sbjct: 181  VVGDKVILSPVNAD-------QQNLHVAANYELPDNPGCKEVNVLNSSTSWKISLFMEHK 233

Query: 808  ENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWE 987
            ENQ++ +K GDVVRLFHA+Q+ FLT+D   KQ      VFLR T R SA  ATSS+ALWE
Sbjct: 234  ENQEHILKGGDVVRLFHAEQEKFLTMDEYKKQYH----VFLRTTGRTSATAATSSKALWE 289

Query: 988  VQVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRPPLLSALSQKSRP 1167
            ++VVQ ++ RGG   WN  YRFKHLAT  YL+AE +++ V          +SA S
Sbjct: 290  IEVVQHDSCRGGAGDWNSLYRFKHLATGHYLAAE-AEIDVSAGA------MSATSASGHD 342

Query: 1168 M-LERTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANLLFQLDPST 1344
            + L   +    +     N   N+     Q  + SV    P  ++        +F LD +T
Sbjct: 343  LHLGDCSKDSGLSCSTMNSTINDKPKGKQYRLVSV----PYSADIAS-----VFVLDATT 393

Query: 1345 FMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWVKVIC-EKNRVDKE 1521
              + +  VP+ SYVRL H  S+ WVHAT+      +   + ++K  + ++C    + DKE
Sbjct: 394  MARPDSLVPQSSYVRLQHICSNTWVHATS------IPIDADDDKPVMSMVCCSPIKEDKE 447

Query: 1522 TFALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTN- 1698
             FAL+PV+P EVRDLDFANDACK L      +  G +   E   +   LL D + F+
Sbjct: 448  AFALIPVSPVEVRDLDFANDACKVLATVTSKLDNGSISINER-RALISLLQDIVYFIAGM 506

Query: 1699 -SSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXX 1875
             +  +    L+ +  +P RDRQKLLREQ +L Q+F +L+ PF   Q  T
Sbjct: 507  ENEQNKTKALEFTIKNPIRDRQKLLREQYILKQLFKILQGPF---QQHTAGDGPFLRLDE 563

Query: 1876 XXDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLH 2055
              D +N  +K +F+LCY +L+ SQ  YRKNQE++A+ FG +Q+QIG+D++AEDT+TA+LH
Sbjct: 564  LSDPKNSPYKNIFRLCYRILRLSQQDYRKNQEYIAKHFGLMQKQIGYDILAEDTITALLH 623

Query: 2056 NNPKLLEKYVKTPHVERFVELVRNNR---QGKFLDYLADLCVCRGEANKKIQELICTSVL 2226
            NN KLLEK++    +E FV LVR N      +FLDYL+DLCV   +A    QELIC SVL
Sbjct: 624  NNRKLLEKHITAAEIETFVGLVRKNMHNWDSRFLDYLSDLCVSNRKAIAVTQELICKSVL 683

Query: 2227 SSKHRDIFMDTKI 2265
            S K++DI ++T++
Sbjct: 684  SDKNKDILIETQV 696


>gi|5689748|emb|CAB51853.1| inositol 1,4,5-trisphosphate receptor
            [Drosophila melanogaster]
          Length = 2828

 Score = 1102 bits (2851), Expect = 0.0
 Identities = 754/2226 (33%), Positives = 1143/2226 (50%), Gaps = 131/2226 (5%)
 Frame = +1

Query: 2275 EIEVGWA--PNFRKLVDIAEGAKSNSDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPER 2448
            EI + W   P  R + D+A        +A  L+YYRHQL+L S MC  +QYLA++
Sbjct: 763  EIHLKWTGQPTSRSMADLAS-CDGGELEAAILNYYRHQLNLFSNMCLNRQYLALN----- 816

Query: 2449 RLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLHLHVVRG--SPMSAIRHARLWWSI 2622
                +S +L  +L+L+CMSD  +PY+LR SF RLMLHLHV R    P++ +++ARLW  I
Sbjct: 817  ---ELSPRLDIDLILKCMSDETMPYELRASFCRLMLHLHVDRDPQEPVTPVKYARLWSEI 873

Query: 2623 PENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATVETYLMGLRNQSMEERQSVNSSKL 2802
            P  +++  Y+  + +   +    R      +  +A VE YL  +  +          +KL
Sbjct: 874  PSKMSIQDYDGKNQQPDQNKQACRAK---FNTTIAFVENYLCNVATKVWLFTDQ-EQNKL 929

Query: 2803 TYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIIN------EGP-ATEQVPSHRAMVNAIR 2961
            T+E+V LA+ L  F FYSF+DLL+LT+ LL+I++       G  A+  + S   ++ +I
Sbjct: 930  TFEVVKLARDLIYFGFYSFSDLLRLTKTLLSILDCVSDTSSGEFASTDIDSEGGVLRSIG 989

Query: 2962 NMSKSMMRGGNKENSKDLAKTPSVTAEE---AGRTKEGRALNVKTKLIVAEILQFVMDVR 3132
            +++  M         + +A  P+++ ++     +  +   L + TKL + EILQF++DVR
Sbjct: 990  DINTVMTSLALGSVGQAIA-APTISLQQRKSVSQLMKEYPLVMDTKLKIIEILQFILDVR 1048

Query: 3133 RDYRITMALSWFKNVF-----PCDEDGSLMHSASINER---------------------- 3231
             DYRI+  LS FK  F     P         S+S N R
Sbjct: 1049 LDYRISCLLSIFKREFDESEVPLRPLAMRQVSSSRNNRNRRRLAAPMRLIPSTVPSLWPP 1108

Query: 3232 ---------------------MASELYDAIYRSSGHELHLDGRDGQLLLAILLQMTMSDY 3348
                                  A  ++D   RS    L LDG+ G+  L +LL + M DY
Sbjct: 1109 RCAAAATTARQKNIDLESIGVQAEGIFDC-ERSDAANLDLDGQGGRTFLRVLLHLIMHDY 1167

Query: 3349 PPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELW 3528
             PL S AL + FRHF+Q QE+L+  +QVQLLVS++DVE+Y+QI  DL IL+   EKSELW
Sbjct: 1168 APLVSGALHLLFRHFSQRQEVLQAFRQVQLLVSDSDVESYKQIKSDLDILRQSVEKSELW 1227

Query: 3529 VHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNEC 3708
            V+         K  DE   T                D+G    +L
Sbjct: 1228 VY-------KAKATDELGAT----------------DAGGDAVSLE-------------- 1250

Query: 3709 LQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDP----KPDT 3876
                N  L ++ RN+                Y  ++++L+R+   C     P    KP
Sbjct: 1251 ---YNAALSQEQRNE----------------YRKVKEILIRMNKFCVTASGPGSVVKPRK 1291

Query: 3877 MNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFI 4056
              Q+LL+N+ V+ VVL+ +  P+D+K D  M +L+ L+HEFL++FC  N++NQ  L+  +
Sbjct: 1292 HEQRLLRNVGVHTVVLDLLQNPYDEKDDELMKELMCLAHEFLQNFCLGNQQNQVLLHNHL 1351

Query: 4057 SYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEEL-IAH-IVGLIEHNSRNPIFL 4230
                     +     I E  T+ AIF++N  L + V +++ + H +V  IE + R+  +L
Sbjct: 1352 D--------LFLNPGILEAKTVCAIFKDNLALCNEVTDKVGVGHSVVHCIEIHGRHVAYL 1403

Query: 4231 ELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSS 4410
            + LQ +V   ++ I   Q+ V  E+  + ++V   Y D  SF     MM+ +     + S
Sbjct: 1404 QFLQTVVAAENQFIRRCQDMVMQELINSGEDVLVFYNDKGSFNHFVQMMQQQMLGMEKLS 1463

Query: 4411 DSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQL 4590
            D    LKYH+ELV+LLA CT GKN  TE+KC + + +D IV ++    C+ EVK  Y+
Sbjct: 1464 DDS-PLKYHVELVKLLACCTMGKNVYTEIKCNNLLSLDDIVTIICHPLCMPEVKEAYVDF 1522

Query: 4591 LLHCYIDTDAEMKDAYKTEYVDHILN-NLLEDIRSLRVEKLTGAETATLEHYICHTVTEV 4767
            L HCYIDT+ EMK+ Y + ++  +   + L DI  L +     A   TL+ Y+ + VT +
Sbjct: 1523 LNHCYIDTEVEMKEIYASGHMWSLFEKSFLVDINQL-ITNPAAASNKTLQAYVLNGVTNL 1581

Query: 4768 LIKFFEAPYS---ALQQAKVDVHHHKKTFSEVLLELTYLEKGKLRGSKSSRNWYRVAECI 4938
            L  FF +P+S   A+ Q++  +       +  + +  +L  G         + + V  CI
Sbjct: 1582 LGSFFASPFSDQSAIVQSRQLIFVQLLQAAHRITQCRWLSLG---------DRFNVENCI 1632

Query: 4939 KRLTKWAEEHNITLPATLAGP--QMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPG 5112
            + LT+ A+  +I LP  L      MS +T++  +      + KW+   K+        P
Sbjct: 1633 RTLTESAKMRSIALPPELEQQVATMSSKTAMLTR-----QTTKWLLASKQ--------PK 1679

Query: 5113 HRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSA 5292
            +     ++ M    S  ++     ++   +  L P+  AE S+LV++L+  ELLFP G+
Sbjct: 1680 YEAQQAASLMRWDRS--IIEGLQDIVSLLEDQLKPVVEAELSLLVDILYRSELLFPAGTE 1737

Query: 5293 LRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKQQLTHQGHRVYNSSV 5472
             R +C  GG + KLI+H + L++ K++ +C +VL+TL +M              +  +
Sbjct: 1738 ARKRCESGGFIRKLIKHTEKLLEEKEERMCVKVLRTLREMM------------AIDVNYG 1785

Query: 5473 EKGXXXXXXXXXXYFGHHNNHHPPLDRQQSXXXXXXXXXXXXXXXTWSQE--------RD 5628
            EKG          YF   +    P D                   T            +
Sbjct: 1786 EKGDALRQTLLLRYFQTKSTPRLPEDEVPLLAAPLMDPAKQNHLVTHGPGAKYLQRAGKT 1845

Query: 5629 LYAIQCKLNDAGASDLVTDIIIMEP-SREIFLKAIHLARALLHEGNDKVQHSFYMRMKQK 5805
            L+ +Q  L+  GASDLV +++I    S  IF++A+ L  ALL  GN  +Q   + +
Sbjct: 1846 LHEMQNHLDREGASDLVVELVIKSVHSPNIFVEAVELGIALLEGGNPIIQKGMFQKFLSD 1905

Query: 5806 DIHEPFFKAILTRIQTAQNRLKS-------DMMSCSDSKPKVSSTVLTPLIDAGDTGFNG 5964
            D+++ FFK    +++ AQ  +KS       D+ + +    + ++  L  +        NG
Sbjct: 1906 DLNQAFFKVFFEKMKDAQQEIKSTVTVNTTDIAAKAHEHKQDTNLELDKIARKHGLKSNG 1965

Query: 5965 ALF--EVPQQVRHPSISEMSQLSN-------------DLTHSIPD-----LAPYQDEEKS 6084
             +   E+ +++ +  ++      N              +   + D     L  ++D
Sbjct: 1966 VVITEELKRELHNAGLATARAYGNARNIHSGEESSAISVNSPLEDILAEKLEKHKDSRDQ 2025

Query: 6085 TDALPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTK 6264
             + L  +V +++PILR LQLLCENHN  +QN LR Q+++TN+NLVSETL FLD +CGST
Sbjct: 2026 RNQLSNKVLVMQPILRFLQLLCENHNPDMQNLLRNQNNKTNNNLVSETLMFLDCICGSTT 2085

Query: 6265 GSLGVFG-EIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQE-NGLNIIISLVLNEIK 6438
            G LG+ G  I EHN +LI QTL  LTE+CQGPCHENQN +A  E NGL+II +L+LN I
Sbjct: 2086 GGLGLLGLYINEHNLALINQTLEALTEYCQGPCHENQNCIATHESNGLDIITALILNNIN 2145

Query: 6439 PLADDHMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYE 6618
            PL ++ M+L LE+K+ ASKLLLAIMESR D ENA R+L NM      PKQLV    +AY
Sbjct: 2146 PLGENRMDLVLELKNNASKLLLAIMESRGDSENAERILYNM-----NPKQLVEVACKAYH 2200

Query: 6619 MTNSNHHMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISS 6798
                          +L  + +D  +  +G
Sbjct: 2201 Q------------EELIDEQDDGDEPDAG------------------------------- 2217

Query: 6799 SLDDKFNDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKK----DDLTREAL 6966
                  +DDD  +V PREVGHNIYIL HQLA H+ EL   L  S++ +    D  T +AL
Sbjct: 2218 ------SDDDDATVSPREVGHNIYILCHQLAQHNKELAGLLKASEDPQSASFDAKTSQAL 2271

Query: 6967 NYYKERTAQIEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDE 7146
             YY   TAQIEIVR DRTLE++VFPI +IC YLT DTK  + N  ERD+QGSK+ +FFD+
Sbjct: 2272 MYYATHTAQIEIVRNDRTLEQIVFPIPEICEYLTTDTKIKILNTAERDDQGSKLADFFDK 2331

Query: 7147 WETMYHEMIWQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYP----LPEHSN 7314
             E M++EM WQ+KL+ +  L W +  + LW+ + F+   ++N +VA +YP    +PE S
Sbjct: 2332 AEEMFNEMKWQKKLRSQPLLFWISSYMSLWSNILFNCVVVINMIVAFFYPFDNTVPELS- 2390

Query: 7315 SSISLGNLYSWFAVFSSFLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFG 7494
            S ISL  L+    +FS  ++    R   I                    +G   TL + G
Sbjct: 2391 SHISL--LFWIITIFSLVIVLALPRESGI------RTFIGSVILRFIFLLGPESTLCLLG 2442

Query: 7495 ILQLVNKIVHVVAFVSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLF 7674
            ++ +  K VH+V+ + NKG  ++ + +I+   + +  L    + +L L+ HP  Y +LLF
Sbjct: 2443 VVTVTLKSVHIVSIMGNKGTLEKQLIKIITDFSTYTALYS--VLLLRLIFHPFFYSLLLF 2500

Query: 7675 DIIFTEETLQNVIASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDS 7854
            D+++ EETL NVI SVTRN +SIV T +LALIL+Y FSI+G+++F+ DF + VD  E D+
Sbjct: 2501 DVVYREETLVNVIRSVTRNGRSIVLTAVLALILVYLFSIIGYMFFKDDFLVSVDFEEQDN 2560

Query: 7855 SA------TISSGIPSETCPSEGCPG-----LQPSXXXXXXXXXXXXSCETLWMCILQTG 8001
            +       T+S  +  ++C +    G      + +            SC++L MCI+ T
Sbjct: 2561 APPPSVPLTLSVPVSGDSCSAPDDLGNCQAAKEVAPPSAGGGEVKERSCDSLVMCIVTTL 2620

Query: 8002 YQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTXXXXXXXXXXXXXXXXXXDTFGDLRAE 8181
             QGLRNGGGIGD+LR P+  E +F+ RV YD+                   DTF DLR+E
Sbjct: 2621 NQGLRNGGGIGDILRAPSSKEGLFVARVIYDLLFFFIVIIIVLNLIFGVIIDTFADLRSE 2680

Query: 8182 KNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGP 8361
            K +KE ILK  CFIC L+RS FDN++V+FE H ++EHN+WHYLY+IV++++KD TEFTGP
Sbjct: 2681 KQQKEAILKTTCFICSLNRSAFDNKTVSFEEHIKSEHNMWHYLYFIVLVKVKDPTEFTGP 2740

Query: 8362 ESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLLQMMTLMREIISQNEES 8541
            ESYV   VK   L+WFPR++A+SL   + D +Q E++ M+ QLL    L++ + +Q  E
Sbjct: 2741 ESYVYAMVKAGILEWFPRLRAMSLAAVDADGEQIELRSMQAQLLDTQLLIKNLSTQLHEL 2800

Query: 8542 RAFMEQ 8559
            +  M +
Sbjct: 2801 KDHMTE 2806



 Score =  540 bits (1391), Expect = e-151
 Identities = 321/734 (43%), Positives = 443/734 (59%), Gaps = 10/734 (1%)
 Frame = +1

Query: 94   GNNGNLHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFK 273
            G+   LH+GDI+SLY E S      GFLSTLGLVDDR +V  + G    PPKKFRDCL K
Sbjct: 7    GSASFLHLGDIVSLYAEGSVC----GFLSTLGLVDDRTVVCPEAGDLSCPPKKFRDCLIK 62

Query: 274  VCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQY 453
            +CP+NRY+AQK  W   K  Q+  S  D +L+ +L  AA+ E+++NE+E +K LG  IQY
Sbjct: 63   ICPMNRYSAQKQFWKAAK--QSASSNTDPNLLKRLHHAAEIEKKQNETENKKLLGTSIQY 120

Query: 454  G-SMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNV 630
            G ++VQLLH+KSNKY+TV K  P+  E+NAM+VYLD  GNEGSWF I+P YK  +IGD V
Sbjct: 121  GRAVVQLLHLKSNKYLTVNKRLPSLLEKNAMRVYLDANGNEGSWFYIKPFYKLRSIGDYV 180

Query: 631  SA-GNKISLIPNSVSTTQAGHVKSQLHLSS-FNLLDHQSAAEVNCLNEPTEWQVFMFLLF 804
               G+K+ L P +         +  LH+++ + L D+    EVN LN  T W++ +F+
Sbjct: 181  VVVGDKVILSPVNAD-------QQNLHVAANYELPDNPGCKEVNVLNSSTSWKISLFMEH 233

Query: 805  DENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALW 984
             ENQ++ +K GDVVRLFHA+Q+ FLT+D   KQ      VFLR T R SA  ATSS+ALW
Sbjct: 234  KENQEHILKGGDVVRLFHAEQEKFLTMDEYKKQYH----VFLRTTGRTSATAATSSKALW 289

Query: 985  EVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRPPLLSALSQKSR 1164
            E++VVQ ++ RGG   WN  YRFKHLAT  YL+AE +++ V          +SA S
Sbjct: 290  EIEVVQHDSCRGGAGDWNSLYRFKHLATGHYLAAE-AEIDVSAGA------MSATSASGH 342

Query: 1165 PM-LERTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANLLFQLDPS 1341
             + L   +    +     N   N+     Q  + SV    P  ++        +F LD +
Sbjct: 343  DLHLGDCSKDSGLSCSTMNSTINDKPKGKQYRLVSV----PYSADIAS-----VFVLDAT 393

Query: 1342 TFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWVKVIC-EKNRVDK 1518
            T  + +  VP+ SYVRL H  S+ WVHAT+      +   + ++K  + ++C    + DK
Sbjct: 394  TMARPDSLVPQSSYVRLQHICSNTWVHATS------IPIDADDDKPVMSMVCCSPIKEDK 447

Query: 1519 ETFALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTN 1698
            E FAL+PV+P EVRDLDFANDACK L      +  G +   E   +   LL D + F+
Sbjct: 448  EAFALIPVSPVEVRDLDFANDACKVLATVTSKLDNGSISINER-RALISLLQDIVYFIAG 506

Query: 1699 --SSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXX 1872
              +  +    L+ +  +P RDRQKLLREQ +L Q+F +L+ PF   Q  T
Sbjct: 507  MENEQNKTKALEFTIKNPIRDRQKLLREQYILKQLFKILQGPF---QEHTAGDGPFLRLD 563

Query: 1873 XXXDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVL 2052
               D +N  +K +F+LCY +L+ SQ  YRKNQE++A+ FG +Q+QIG+D++AEDT+TA+L
Sbjct: 564  ELSDPKNSPYKNIFRLCYRILRLSQQDYRKNQEYIAKHFGLMQKQIGYDILAEDTITALL 623

Query: 2053 HNNPKLLEKYVKTPHVERFVELVRNNR---QGKFLDYLADLCVCRGEANKKIQELICTSV 2223
            HNN KLLEK++    +E FV LVR N      +FLDYL+DLCV   +A    QELIC SV
Sbjct: 624  HNNRKLLEKHITAAEIETFVGLVRKNMHNWDSRFLDYLSDLCVSNRKAIAVTQELICKSV 683

Query: 2224 LSSKHRDIFMDTKI 2265
            LS K++DI ++T++
Sbjct: 684  LSDKNKDILIETQV 697


>gi|345496|pir||A43360 inositol 1,4,5-trisphosphate receptor - fruit
            fly  (Drosophila melanogaster)
 gi|217338|dbj|BAA14399.1| inositol 1,4,5-trisphosphate receptor
            [Drosophila melanogaster]
          Length = 2833

 Score = 1100 bits (2846), Expect = 0.0
 Identities = 750/2232 (33%), Positives = 1137/2232 (50%), Gaps = 137/2232 (6%)
 Frame = +1

Query: 2275 EIEVGWA--PNFRKLVDIAEGAKSNSDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPER 2448
            EI + W   P  R + D+A        +A  L+YYRHQL+L S MC  +QYLA++
Sbjct: 763  EIHLKWTGQPTSRSMADLAS-CDGGELEAAILNYYRHQLNLFSNMCLNRQYLALN----- 816

Query: 2449 RLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLHLHVVRG--SPMSAIRHARLWWSI 2622
                +S +L  +L+L+CMSD  +PY+LR SF RLMLHLHV R    P++ +++ARLW  I
Sbjct: 817  ---ELSPRLDIDLILKCMSDETMPYELRASFCRLMLHLHVDRDPQEPVTPVKYARLWSEI 873

Query: 2623 PENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATVETYLMGLRNQSMEERQSVNSSKL 2802
            P  +++  Y+  + +   +    R      +  +A VE YL  +  +          +KL
Sbjct: 874  PSKMSIQDYDGKNQQPDQNKQACRAK---FNTTIAFVENYLCNVATKVWLFTDQ-EQNKL 929

Query: 2803 TYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINEGPATEQVPSHRAMVNAIRNMSKSMM 2982
            T+E+V LA+ L  F FYSF+DLL+LT+ LL+I++    T         ++++   + +
Sbjct: 930  TFEVVKLARDLIYFGFYSFSDLLRLTKTLLSILDCVSDTSSGEFASTDIDSVEEETNAEA 989

Query: 2983 RGGNKENSKDL---------------AKTPSVTAEE---AGRTKEGRALNVKTKLIVAEI 3108
             GG   +  D+                  P+++ ++     +  +   L + TKL + EI
Sbjct: 990  EGGVLRSIGDINTVMTSLALGSVGQAIAAPTISLQQRKSVSQLMKEYPLVMDTKLKIIEI 1049

Query: 3109 LQFVMDVRRDYRITMALSWFKNVF-----PCDEDGSLMHSASINER-------------- 3231
            LQF++DVR DYRI+  LS FK  F     P         S+S N R
Sbjct: 1050 LQFILDVRLDYRISCLLSIFKREFDESEVPLRPLAMRQVSSSRNNRNRRRLAAPMRLIPS 1109

Query: 3232 -----------------------------MASELYDAIYRSSGHELHLDGRDGQLLLAIL 3324
                                          A  ++D     +   L LDG+ G+  L +L
Sbjct: 1110 TVPSLWPPRCAAAATTARQKNIDLESIGVQAEGIFDC--ERTPANLDLDGQGGRTFLRVL 1167

Query: 3325 LQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKN 3504
            L + M DY PL S AL + FRHF+Q QE+L+  +QVQLLVS++DVE+Y+QI  DL IL+
Sbjct: 1168 LHLIMHDYAPLVSGALHLLFRHFSQRQEVLQAFRQVQLLVSDSDVESYKQIKSDLDILRQ 1227

Query: 3505 LTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEH 3684
              EKSELWV+         K  DE   T                D+G    +L
Sbjct: 1228 SVEKSELWVY-------KAKATDELGAT----------------DAGGDAVSLE------ 1258

Query: 3685 YPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDP 3864
                        N  L ++ RN+                Y  ++++L+R+   C     P
Sbjct: 1259 -----------YNAALSQEQRNE----------------YRKVKEILIRMNKFCVTASGP 1291

Query: 3865 ----KPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKEN 4032
                KP    Q+LL+N+ V+ VVL+ +  P+D+K D  M +L+ L+HEFL++FC  N++N
Sbjct: 1292 GSVVKPRKHEQRLLRNVGVHTVVLDLLQNPYDEKDDELMKELMCLAHEFLQNFCLGNQQN 1351

Query: 4033 QSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNS 4212
            Q  L+  +         +     I E  T+ AIF++N  L + V ++++ H V  IE +
Sbjct: 1352 QVLLHNHLD--------LFLNPGILEAKTVCAIFKDNLALCNEVTDKVV-HFVHCIEIHG 1402

Query: 4213 RNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKE 4392
            R+  +L+ LQ +V   ++ I   Q+ V  E+  + ++V   Y D  SF     MM+ +
Sbjct: 1403 RHVAYLQFLQTVVAAENQFIRRCQDMVMQELINSGEDVLVFYNDKGSFNHFVQMMQQQML 1462

Query: 4393 SKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVK 4572
               + SD    LKYH+ELV+LLA CT GKN  TE+KC + + +D IV ++    C+ EVK
Sbjct: 1463 GMEKLSDDS-PLKYHVELVKLLACCTMGKNVYTEIKCNNLLSLDDIVTIICHPLCMPEVK 1521

Query: 4573 TVYLQLLLHCYIDTDAEMKDAYKTEYVDHILN-NLLEDIRSLRVEKLTGAETATLEHYIC 4749
              Y+  L HCYIDT+ EMK+ Y + ++  +   + L DI  L +     A   TL+ Y+
Sbjct: 1522 EAYVDFLNHCYIDTEVEMKEIYASGHMWSLFEKSFLVDINQL-ITNPAAASNKTLQAYVL 1580

Query: 4750 HTVTEVLIKFFEAPYS---ALQQAKVDVHHHKKTFSEVLLELTYLEKGKLRGSKSSRNWY 4920
            + VT +L  FF +P+S   A+ Q++  +       +  + +  +L  G         + +
Sbjct: 1581 NGVTNLLGSFFASPFSDQSAIVQSRQLIFVQLLQAAHRITQCRWLSLG---------DRF 1631

Query: 4921 RVAECIKRLTKWAEEHNITLPATLAGP--QMSGQTSVRQKWQQAASSAKWIGIGKRLNRQ 5094
             V  CI+ LT+ A+  +I LP  L      MS +T++  +      + KW+   K+
Sbjct: 1632 NVENCIRTLTESAKMRSIALPPELEQQVATMSSKTAMLTR-----QTTKWLLASKQ---- 1682

Query: 5095 NTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELL 5274
                P +     ++ M    S  ++     ++   +  L P+  AE S+LV++L+  ELL
Sbjct: 1683 ----PKYEAQQAASLMRWDRS--IIEGLQDIVSLLEDQLKPVVEAELSLLVDILYRSELL 1736

Query: 5275 FPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKQQLTHQGHR 5454
            FP G+  R +C  GG + KLI+H + L++ K++ +C +VL+TL +M
Sbjct: 1737 FPAGTEARKRCESGGFIRKLIKHTEKLLEEKEERMCVKVLRTLREMM------------A 1784

Query: 5455 VYNSSVEKGXXXXXXXXXXYFGHHNNHHPPLDRQQSXXXXXXXXXXXXXXXTWSQE---- 5622
            +  +  EKG          YF   +    P D                   T
Sbjct: 1785 IDVNYGEKGDALRQTLLLRYFQTKSTPRLPEDEVPLLAAPLMDPAKQNHLVTHGPGAKYL 1844

Query: 5623 ----RDLYAIQCKLNDAGASDLVTDIIIMEP-SREIFLKAIHLARALLHEGNDKVQHSFY 5787
                + L+ +Q  L+  GASDLV +++I    S  IF++A+ L  ALL  GN  +Q   +
Sbjct: 1845 QRAGKTLHEMQNHLDREGASDLVVELVIKSVHSPNIFVEAVELGIALLEGGNPIIQKGMF 1904

Query: 5788 MRMKQKDIHEPFFKAILTRIQTAQNRLKS-------DMMSCSDSKPKVSSTVLTPLIDAG 5946
             +    D+++ FFK    +++ AQ  +KS       D+ + +    + ++  L  +
Sbjct: 1905 QKFLSDDLNQAFFKVFFEKMKDAQQEIKSTVTVNTTDIAAKAHEHKQDTNLELDKIARKH 1964

Query: 5947 DTGFNGALF--EVPQQVRHPSISEMSQLSN-------------DLTHSIPD-----LAPY 6066
                NG +   E+ +++ +  ++      N              +   + D     L  +
Sbjct: 1965 GLKSNGVVITEELKRELHNAGLATARAYGNARNIHSGEESSAISVNSPLEDILAEKLEKH 2024

Query: 6067 QDEEKSTDALPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDT 6246
            +D     + L  +V +++PILR LQLLCENHN  +QN LR Q+++TN+NLVSETL FLD
Sbjct: 2025 KDSRDQRNQLSNKVLVMQPILRFLQLLCENHNPDMQNLLRNQNNKTNNNLVSETLMFLDC 2084

Query: 6247 VCGSTKGSLGVFG-EIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQE-NGLNIIISL 6420
            +CGST G LG+ G  I EHN +LI QTL  LTE+CQGPCHENQN +A  E NGL+II +L
Sbjct: 2085 ICGSTTGGLGLLGLYINEHNLALINQTLEALTEYCQGPCHENQNCIATHESNGLDIITAL 2144

Query: 6421 VLNEIKPLADDHMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHA 6600
            +LN I PL ++ M+L LE+K+ ASKLLLAIMESR D ENA R+L NM      PKQLV
Sbjct: 2145 ILNNINPLGENRMDLVLELKNNASKLLLAIMESRGDSENAERILYNM-----NPKQLVEV 2199

Query: 6601 IKQAYEMTNSNHHMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHT 6780
              +AY               +L  + +D  +  +G
Sbjct: 2200 ACKAYHQ------------EELIDEQDDGDEPDAG------------------------- 2222

Query: 6781 EKNISSSLDDKFNDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKK----DD 6948
                        +DDD  +V PREVGHNIYIL HQLA H+ EL   L  S++ +    D
Sbjct: 2223 ------------SDDDDATVSPREVGHNIYILCHQLAQHNKELAGLLKASEDPQSASFDA 2270

Query: 6949 LTREALNYYKERTAQIEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKV 7128
             T +AL YY   TAQIEIVR DRTLE++VFPI +IC YLT DTK  + N  ERD+QGSK+
Sbjct: 2271 KTSQALMYYATHTAQIEIVRNDRTLEQIVFPIPEICEYLTTDTKIKILNTAERDDQGSKL 2330

Query: 7129 TEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYP---- 7296
             +FFD+ E M++EM WQ+KL+ +  L W +  + LW+ + F+   ++N +VA +YP
Sbjct: 2331 ADFFDKAEEMFNEMKWQKKLRSQPLLFWISSYMSLWSNILFNCVVVINMIVAFFYPFDNT 2390

Query: 7297 LPEHSNSSISLGNLYSWFAVFSSFLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTL 7476
            +PE S S ISL  L+    +FS  ++    R   I                    +G
Sbjct: 2391 VPELS-SHISL--LFWIITIFSLVIVLALPRESGI------RTFIGSVILRFIFLLGPES 2441

Query: 7477 TLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMI 7656
            TL + G++ +  K VH+V+ + NKG  ++ + +I+   + +  L    + +L L+ HP
Sbjct: 2442 TLCLLGVVTVTLKSVHIVSIMGNKGTLEKQLIKIITDFSTYTALYS--VLLLRLIFHPFF 2499

Query: 7657 YCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVD 7836
            Y +LLFD+++ EETL NVI SVTRN +SIV T +LALIL+Y FSI+G+++F+ DF + VD
Sbjct: 2500 YSLLLFDVVYREETLVNVIRSVTRNGRSIVLTAVLALILVYLFSIIGYMFFKDDFLVSVD 2559

Query: 7837 PVENDSSA------TISSGIPSETCPSEGCPG-----LQPSXXXXXXXXXXXXSCETLWM 7983
              E D++       T+S  +  ++C +    G      + +            SC++L M
Sbjct: 2560 FEEQDNAPPPSVPLTLSVPVSGDSCSAPDDLGNCQAAKEVAPPSAGGGEVKERSCDSLVM 2619

Query: 7984 CILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTXXXXXXXXXXXXXXXXXXDTF 8163
            CI+ T  QGLRNGGGIGD+LR P+  E +F+ RV YD+                   DTF
Sbjct: 2620 CIVTTLNQGLRNGGGIGDILRAPSSKEGLFVARVIYDLLFFFIVIIIVLNLIFGVIIDTF 2679

Query: 8164 GDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLYYIVMLQIKDE 8343
             DLR+EK +KE ILK  CFIC L+RS FDN++V+FE H ++EHN+WHYLY+IV++++KD
Sbjct: 2680 ADLRSEKQQKEAILKTTCFICSLNRSAFDNKTVSFEEHIKSEHNMWHYLYFIVLVKVKDP 2739

Query: 8344 TEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLLQMMTLMREII 8523
            TEFTGPESYV   VK   L+WFPR++A+SL   + D +Q E++ M+ QLL    L++ +
Sbjct: 2740 TEFTGPESYVYAMVKAGILEWFPRLRAMSLAAVDADGEQIELRSMQAQLLDTQLLIKFLS 2799

Query: 8524 SQNEESRAFMEQ 8559
            +Q  E +  M +
Sbjct: 2800 TQLHELKDHMTE 2811



 Score =  540 bits (1391), Expect = e-151
 Identities = 321/734 (43%), Positives = 443/734 (59%), Gaps = 10/734 (1%)
 Frame = +1

Query: 94   GNNGNLHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFK 273
            G+   LH+GDI+SLY E S      GFLSTLGLVDDR +V  + G    PPKKFRDCL K
Sbjct: 7    GSASFLHLGDIVSLYAEGSVC----GFLSTLGLVDDRTVVCPEAGDLSCPPKKFRDCLIK 62

Query: 274  VCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQY 453
            +CP+NRY+AQK  W   K  Q+  S  D +L+ +L  AA+ E+++NE+E +K LG  IQY
Sbjct: 63   ICPMNRYSAQKQFWKAAK--QSASSNTDPNLLKRLHHAAEIEKKQNETENKKLLGTSIQY 120

Query: 454  G-SMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNV 630
            G ++VQLLH+KSNKY+TV K  P+  E+NAM+VYLD  GNEGSWF I+P YK  +IGD V
Sbjct: 121  GRAVVQLLHLKSNKYLTVNKRLPSLLEKNAMRVYLDANGNEGSWFYIKPFYKLRSIGDYV 180

Query: 631  SA-GNKISLIPNSVSTTQAGHVKSQLHLSS-FNLLDHQSAAEVNCLNEPTEWQVFMFLLF 804
               G+K+ L P +         +  LH+++ + L D+    EVN LN  T W++ +F+
Sbjct: 181  VVVGDKVILSPVNAD-------QQNLHVAANYELPDNPGCKEVNVLNSSTSWKISLFMEH 233

Query: 805  DENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALW 984
             ENQ++ +K GDVVRLFHA+Q+ FLT+D   KQ      VFLR T R SA  ATSS+ALW
Sbjct: 234  KENQEHILKGGDVVRLFHAEQEKFLTMDEYKKQYH----VFLRTTGRTSATAATSSKALW 289

Query: 985  EVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRPPLLSALSQKSR 1164
            E++VVQ ++ RGG   WN  YRFKHLAT  YL+AE +++ V          +SA S
Sbjct: 290  EIEVVQHDSCRGGAGDWNSLYRFKHLATGHYLAAE-AEIDVSAGA------MSATSASGH 342

Query: 1165 PM-LERTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANLLFQLDPS 1341
             + L   +    +     N   N+     Q  + SV    P  ++        +F LD +
Sbjct: 343  DLHLGDCSKDSGLSCSTMNSTINDKPKGKQYRLVSV----PYSADIAS-----VFVLDAT 393

Query: 1342 TFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWVKVIC-EKNRVDK 1518
            T  + +  VP+ SYVRL H  S+ WVHAT+      +   + ++K  + ++C    + DK
Sbjct: 394  TMARPDSLVPQSSYVRLQHICSNTWVHATS------IPIDADDDKPVMSMVCCSPIKEDK 447

Query: 1519 ETFALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTN 1698
            E FAL+PV+P EVRDLDFANDACK L      +  G +   E   +   LL D + F+
Sbjct: 448  EAFALIPVSPVEVRDLDFANDACKVLATVTSKLDNGSISINER-RALISLLQDIVYFIAG 506

Query: 1699 --SSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXX 1872
              +  +    L+ +  +P RDRQKLLREQ +L Q+F +L+ PF   Q  T
Sbjct: 507  MENEQNKTKALEFTIKNPIRDRQKLLREQYILKQLFKILQGPF---QEHTAGDGPFLRLD 563

Query: 1873 XXXDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVL 2052
               D +N  +K +F+LCY +L+ SQ  YRKNQE++A+ FG +Q+QIG+D++AEDT+TA+L
Sbjct: 564  ELSDPKNSPYKNIFRLCYRILRLSQQDYRKNQEYIAKHFGLMQKQIGYDILAEDTITALL 623

Query: 2053 HNNPKLLEKYVKTPHVERFVELVRNNR---QGKFLDYLADLCVCRGEANKKIQELICTSV 2223
            HNN KLLEK++    +E FV LVR N      +FLDYL+DLCV   +A    QELIC SV
Sbjct: 624  HNNRKLLEKHITAAEIETFVGLVRKNMHNWDSRFLDYLSDLCVSNRKAIAVTQELICKSV 683

Query: 2224 LSSKHRDIFMDTKI 2265
            LS K++DI ++T++
Sbjct: 684  LSDKNKDILIETQV 697


>gi|111838|pir||A36579 inositol 1,4,5-triphosphate receptor 1 - rat
 gi|204675|gb|AAA41358.1| inositol-1,4,5-triphosphate receptor (alt.,
            clone pI16)
          Length = 2749

 Score = 1055 bits (2729), Expect = 0.0
 Identities = 679/1833 (37%), Positives = 1000/1833 (54%), Gaps = 65/1833 (3%)
 Frame = +1

Query: 109  LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
            LHIGDI SLY E S+N    GF+STLGLVDDRC+V+ + G   +PPKKFRDCLFK+CP+N
Sbjct: 9    LHIGDICSLYAEGSTN----GFISTLGLVDDRCVVQPEAGDLNNPPKKFRDCLFKLCPMN 64

Query: 289  RYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQ 468
            RY+AQK  W   K     +S  D  L+NKL  AAD E+++NE+E +K LG VIQYG+++Q
Sbjct: 65   RYSAQKQFWKAAK--PGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQ 122

Query: 469  LLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKI 648
            LLH+KSNKY+TV K  PA  E+NAM+V LD AGNEGSWF I+P YK  +IGD+V  G+K+
Sbjct: 123  LLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGDKV 182

Query: 649  SLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSV 828
             L P       AG     LH SS  L+D+    EVN +N  T W++ +F+ + +N+ + +
Sbjct: 183  VLNP-----VNAG---QPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDIL 234

Query: 829  KSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTN 1008
            K GDVVRLFHA+Q+ FLT D   K+      VFLR T R SA  ATSS+ALWEV+VVQ +
Sbjct: 235  KGGDVVRLFHAEQEKFLTCDEHRKKQH----VFLRTTGRQSATSATSSKALWEVEVVQHD 290

Query: 1009 AYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRPPLLSALSQKSRPMLERTNN 1188
              RGG   WN  +RFKHLAT  YL+AE      +  +  +P  +      SR  L
Sbjct: 291  PCRGGAGYWNSLFRFKHLATGHYLAAEVDPDFEEECLEFQPS-VDPDQDASRSRLRNAQE 349

Query: 1189 PMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPE-EDANLLFQLDPSTFMKSNKE 1365
             M +YS                 + SV          PE  D + +F+LDP+T    +
Sbjct: 350  KM-VYS-----------------LVSV----------PEGNDISSIFELDPTTLRGGDSL 381

Query: 1366 VPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKG-WVKVICEKNRVDKETFALLPV 1542
            VPR SYVRL H  ++ WVH+T      N+    + EK   +K+     + DKE FA++PV
Sbjct: 382  VPRNSYVRLRHLCTNTWVHST------NIPIDKEEEKPVMLKIGTSPLKEDKEAFAIVPV 435

Query: 1543 NPDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADP 1722
            +P EVRDLDFANDA K L +    ++ G +   E   S T+LL D + FVT  ++   D
Sbjct: 436  SPAEVRDLDFANDASKVLGSIAGKLEKGTITQNER-RSVTKLLEDLVYFVTGGTNSGQDV 494

Query: 1723 LKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIF 1902
            L++    P+R+RQKL+REQ +L Q+F LL+APF     T              D R+  F
Sbjct: 495  LEVVFSKPNRERQKLMREQNILKQIFKLLQAPF-----TDCGDGPMLRLEELGDQRHAPF 549

Query: 1903 KTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKY 2082
            + + +LCY +L++SQ  YRKNQE++A++FG +Q+QIG+D++AEDT+TA+LHNN KLLEK+
Sbjct: 550  RHICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKH 609

Query: 2083 VKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTK 2262
            +    ++ FV LVR NR+ +FLDYL+DLCV   ++    QELIC +VL+  + DI ++TK
Sbjct: 610  ITAAEIDTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETK 669

Query: 2263 II---------------------DGEIEVGWAPNFRKL-----VDIAEGAK-SNSDDAEH 2361
            ++                     + E+ + W  + +++      ++A+ AK    +D +
Sbjct: 670  LVLSRFEFEGVSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDAKEGQKEDRDV 729

Query: 2362 LDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSF 2541
            L YYR+QL+L ++MC ++QYLAI+         IS QL  +L+L+CMSD  LPYDLR SF
Sbjct: 730  LSYYRYQLNLFARMCLDRQYLAIN--------EISGQLDVDLILRCMSDENLPYDLRASF 781

Query: 2542 TRLMLHLHVVRG--SPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAH 2715
             RLMLH+HV R     ++ +++ARLW  IP  + +  Y+S      S  S+  I E  A
Sbjct: 782  CRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDS------SGASKDEIKERFA- 834

Query: 2716 KVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLA 2895
            + +  VE YL  +  Q          +KLT+E+VNLA+ L  F FY+F+DLL+LT+ LLA
Sbjct: 835  QTMEFVEEYLRDVVCQRFPFSDK-EKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLA 893

Query: 2896 IINEGPATEQVPSHRAM-------VNAIRN-------MSKSMMRGGNKENSKDLAKTPSV 3033
            I++    T   P  +          N +R+       M++ ++RGG       +A  P
Sbjct: 894  ILDCVHVTTIFPISKMTKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEG 953

Query: 3034 TAEEAGRTKEGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFP---------- 3183
              ++A   KE   + + TKL + EILQF+++VR DYRI+  L  FK  F
Sbjct: 954  NVKQAEPEKED-IMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQSSETS 1012

Query: 3184 ---CDEDGSLMHSASINERMASELYDAIYRSSGHE--LHLDGRDGQLLLAILLQMTMSDY 3348
                 ++G      +++     E  + I+  S     L LD   G+  L +LL +TM DY
Sbjct: 1013 SGNSSQEGPSNVPGALDFEHIEEQAEGIFGGSEENTPLDLDDHGGRTFLRVLLHLTMHDY 1072

Query: 3349 PPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELW 3528
            PPL S AL++ FRHF+Q QE+L+  KQVQLLV++ DV+NY+QI +DL  L+++ EKSELW
Sbjct: 1073 PPLVSGALQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELW 1132

Query: 3529 VHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNEC 3708
            V+  +      + +D      EH   +     P   +S  S
Sbjct: 1133 VYKGQG---PDEPMDGASGENEHKKTEEGTSKPLKHESTSSYN----------------- 1172

Query: 3709 LQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDP--KPDTMN 3882
                                           Y +++++L+RL+ +C ++     K
Sbjct: 1173 -------------------------------YRVVKEILIRLSKLCVQESASVRKSRKQQ 1201

Query: 3883 QQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFISY 4062
            Q+LL+NM  + VVLE + +P++K  D  M +++ L+HEFL++FC  N++NQ+ L+K I+
Sbjct: 1202 QRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHIN- 1260

Query: 4063 EKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQ 4242
                   +     I E  T+  IF NN +L S + E ++ H V  IE + RN  +++ LQ
Sbjct: 1261 -------LFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQ 1313

Query: 4243 ALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSDSRR 4422
             +V    K I+  Q+ V  E+  + ++V   Y D ASF+ L  MM+ E++   R  ++
Sbjct: 1314 TIVKAEGKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERD---RMDENSP 1370

Query: 4423 KLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHC 4602
               YHI LV LLA+CT GKN  TE+KC S +P+D IVRVVT + C+ EVK  Y+  L HC
Sbjct: 1371 LFMYHIHLVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHC 1430

Query: 4603 YIDTDAEMKDAYKTEYVDHILNNLLEDI-RSLRVEKLTGAETATLEHYICHTVTEVLIKF 4779
            Y+DT+ EMK+ Y + ++  +  N L DI R+           + LE Y+   V  ++  F
Sbjct: 1431 YVDTEVEMKEIYTSNHMWKLFENFLVDICRACNNTSDRKHADSVLEKYVTEIVMSIVTTF 1490

Query: 4780 FEAPYSALQQAKVDVHHHKKTFSEVLLEL--TYLEKGKLRGSKSSRNWYRVAECIKRLTK 4953
            F +P+S        +   +  F ++L  +   Y     +   K+S     V  CI+ L+
Sbjct: 1491 FSSPFS---DQSTTLQTRQPVFVQLLQGVFRVYHCNWLMPSQKAS-----VESCIRVLSD 1542

Query: 4954 WAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGHRLYGTS 5133
             A+   I +P  L        + V   + ++ +  +   +  RL+ +N       L  +
Sbjct: 1543 VAKSRAIAIPVDL-------DSQVNNLFLKSHNIVQKTAMNWRLSARNAARRDSVLAASR 1595

Query: 5134 NSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCAR 5313
            +        N++     ++   +  L PL  AE SVLV+VLH PELLFPE +  R +C
Sbjct: 1596 D------YRNIIERLQDIVSALEDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKCES 1649

Query: 5314 GGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKM 5412
            GG + KLI+H K L++  ++ LC +VLQTL +M
Sbjct: 1650 GGFICKLIKHTKQLLEENEEKLCIKVLQTLREM 1682



 Score =  613 bits (1582), Expect = e-173
 Identities = 376/1010 (37%), Positives = 551/1010 (54%), Gaps = 30/1010 (2%)
 Frame = +1

Query: 5620 ERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMK 5799
            E  L  +QC L+  GAS+LV D+I+   S  +F ++I LA ALL  GN  +QHSF+ R+
Sbjct: 1788 EMSLAEVQCHLDKEGASNLVIDLIMNASSDRVFHESILLAIALLEGGNTTIQHSFFCRLT 1847

Query: 5800 QKDIHEPFFKAILTRIQTAQNRLKSDM-MSCSDSKPKVSSTVL---TPLIDAGDTGFNGA 5967
            +    E FFK    R++ AQ  +K+ + ++ SD   K     +    P
Sbjct: 1848 EDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPTTQI 1907

Query: 5968 LFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQ---------DEEKSTDALPPEVALVE 6120
              EV  Q+   S +     +     + PD   YQ         D+ K    +   + +++
Sbjct: 1908 TEEVRDQLLEASAATRKAFTTFRREADPD-DHYQSGEGTQATTDKAKDDLEMSAVITIMQ 1966

Query: 6121 PILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFG-EIGE 6297
            PILR LQLLCENHN  LQNFLR Q+++TN+NLV ETL FLD +CGST G LG+ G  I E
Sbjct: 1967 PILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINE 2026

Query: 6298 HNFSLITQTLATLTEFCQGPCHENQNTMAMQE-NGLNIIISLVLNEIKPLADDHMELALE 6474
             N +LI QTL +LTE+CQGPCHENQN +A  E NG++II +L+LN              +
Sbjct: 2027 KNVALINQTLESLTEYCQGPCHENQNCIATHESNGIDIITALILN--------------D 2072

Query: 6475 IKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSI 6654
            I     K +  ++E           L+N A+     K L+  ++  ++  N+   +
Sbjct: 2073 INPLGKKRMDLVLE-----------LKNNAS-----KLLLAIMESRHDSENAERILYNMR 2116

Query: 6655 SRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIP 6834
             ++L      ++ KK+  Q  V                            +D  N +D
Sbjct: 2117 PKELV-----EVIKKAYMQGEVE--------------------------FEDGENGED-G 2144

Query: 6835 SVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRD 7014
            +  PR VGHNIYILAHQLA H+ EL+  L    +   D   EAL +Y + TAQIEIVR D
Sbjct: 2145 AASPRNVGHNIYILAHQLARHNKELQTMLKPGGQVDGD---EALEFYAKHTAQIEIVRLD 2201

Query: 7015 RTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQD 7194
            RT+E++VFP+  IC +LTK++K  +Y  TERD QGSK+ +FF   E +++EM WQ+KL+
Sbjct: 2202 RTMEQIVFPVPSICEFLTKESKLRIYYTTERDEQGSKINDFFLRSEDLFNEMNWQKKLRA 2261

Query: 7195 RKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSIS---LGNLYSWFAVFSS 7365
            +  L WCA  +  W+ +SF+ A ++N LVA +YP       ++     G L++   +  +
Sbjct: 2262 QPVLYWCARNMSFWSSISFNLAVLMNLLVAFFYPFKGVRGGTLEPHWSGLLWTAMLISLA 2321

Query: 7366 FLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVAFVSN 7545
             ++A    H                       +G+  TL++ G   + NKI+ +++FV N
Sbjct: 2322 IVIALPKPHG-------IRALIASTILRLIFSVGLQPTLFLLGAFNVCNKIIFLMSFVGN 2374

Query: 7546 KGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVT 7725
             G   R    ++      Y L+YL IC +GL VH   Y +LLFD+++ EETL NVI SVT
Sbjct: 2375 CGTFTRGYRAMVLDVEFLYHLLYLLICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVT 2434

Query: 7726 RNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSS------ATISSGIPSE 7887
            RN + I+ T  LALIL+Y FSI+G+L+F+ DF LEVD + N+++      +  +  + S+
Sbjct: 2435 RNGRPIILTAALALILVYLFSIVGYLFFKDDFILEVDRLPNETAGPETGESLANDFLYSD 2494

Query: 7888 TC---PSEGCPGLQPSXXXX---XXXXXXXXSCETLWMCILQTGYQGLRNGGGIGDVLRN 8049
             C     E C    P                +CETL MCI+     GLR+GGG+GDVLR
Sbjct: 2495 VCRVETGENCTSPAPKEELLPVEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRK 2554

Query: 8050 PAPWEDMFIWRVAYDMTXXXXXXXXXXXXXXXXXXDTFGDLRAEKNEKEQILKNNCFICG 8229
            P+  E +F  RV YD+                   DTF DLR+EK +KE+ILK  CFICG
Sbjct: 2555 PSKEEPLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICG 2614

Query: 8230 LDRSRFDNRSVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWF 8409
            L+R +FDN++VTFE H + EHN+WHYL +IV++++KD TE+TGPESYVA+ +++RNLDWF
Sbjct: 2615 LERDKFDNKTVTFEEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIRERNLDWF 2674

Query: 8410 PRMQALSLQDSELDTDQSEVKQMKDQLLQMMTLMREIISQNEESRAFMEQ 8559
            PRM+A+SL  S+ + +Q+E++ ++++L   M L+  +  Q  E +  M +
Sbjct: 2675 PRMRAMSLVSSDSEGEQNELRNLQEKLESTMKLVTNLSGQLSELKDQMTE 2724


>gi|17366467|sp|Q14643|IP3R_HUMAN Inositol 1,4,5-trisphosphate
            receptor type 1 (Type 1 inositol 1,4,5-trisphosphate
            receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform
            1) (InsP3R1) (IP3R)
          Length = 2758

 Score = 1054 bits (2726), Expect = 0.0
 Identities = 681/1843 (36%), Positives = 1000/1843 (53%), Gaps = 75/1843 (4%)
 Frame = +1

Query: 109  LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
            LHIGDI SLY E S+N    GF+STLGLVDDRC+V+ + G   +PPKKFRDCLFK+CP+N
Sbjct: 9    LHIGDICSLYAEGSTN----GFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKLCPMN 64

Query: 289  RYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQ 468
            RY+AQK  W   K     +S  D  L+NKL  AAD E+++NE+E +K LG VIQYG+++Q
Sbjct: 65   RYSAQKQFWKAAK--PGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQ 122

Query: 469  LLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKI 648
            LLH+KSNKY+TV K  PA  E+NAM+V LD AGNEGSWF I+P YK  +IGD+V  G+K+
Sbjct: 123  LLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGDKV 182

Query: 649  SLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSV 828
             L P       AG     LH SS  L+D+    EVN +N  T W++ +F+ + +N+ + +
Sbjct: 183  VLNP-----VNAG---QPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDIL 234

Query: 829  KSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTN 1008
            K GDVVRLFHA+Q+ FLT D   K+      VFLR T R SA  ATSS+ALWEV+VVQ +
Sbjct: 235  KGGDVVRLFHAEQEKFLTCDEHRKKQH----VFLRTTGRQSATSATSSKALWEVEVVQHD 290

Query: 1009 AYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRPPLLSALSQKSRPMLERTNN 1188
              RGG   WN  +RFKHLAT  YL+AE      +  +  +P  +      SR  L
Sbjct: 291  PCRGGAGYWNSLFRFKHLATGHYLAAEVDPDFEEECLEFQPS-VDPDQDASRSRLRNAQE 349

Query: 1189 PMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPE-EDANLLFQLDPSTFMKSNKE 1365
             M +YS                 + SV          PE  D + +F+LDP+T    +
Sbjct: 350  KM-VYS-----------------LVSV----------PEGNDISSIFELDPTTLRGGDSL 381

Query: 1366 VPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKG-WVKVICEKNRVDKETFALLPV 1542
            VPR SYVRL H  ++ WVH+T      N+    + EK   +K+     + DKE FA++PV
Sbjct: 382  VPRNSYVRLRHLCTNTWVHST------NIPIDKEEEKPVMLKIGTSPVKEDKEAFAIVPV 435

Query: 1543 NPDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADP 1722
            +P EVRDLDFANDA K L +    ++ G +   E   S T+LL D + FVT  ++   D
Sbjct: 436  SPAEVRDLDFANDASKVLGSIAGKLEKGTITQNER-RSVTKLLEDLVYFVTGGTNSGQDV 494

Query: 1723 LKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIF 1902
            L++    P+R+RQKL+REQ +L Q+F LL+APF     T              D R+  F
Sbjct: 495  LEVVFSKPNRERQKLMREQNILKQIFKLLQAPF-----TDCGDGPMLRLEELGDQRHAPF 549

Query: 1903 KTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKY 2082
            + + +LCY +L++SQ  YRKNQE++A++FG +Q+QIG+D++AEDT+TA+LHNN KLLEK+
Sbjct: 550  RHICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKH 609

Query: 2083 VKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTK 2262
            +    ++ FV LVR NR+ +FLDYL+DLCV   ++    QELIC +VL+  + DI ++TK
Sbjct: 610  ITAAEIDTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETK 669

Query: 2263 II----------------------DGEIEVGWAPNFRKL-----VDIAEGAK-SNSDDAE 2358
            ++                      + E+ + W  + +++      ++A+ AK    +D +
Sbjct: 670  LVLSRFEFEGVSSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDAKEGQKEDRD 729

Query: 2359 HLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGS 2538
             L YYR+QL+L ++MC ++QYLAI+         IS QL  +L+L+CMSD  LPYDLR S
Sbjct: 730  VLSYYRYQLNLFARMCLDRQYLAIN--------EISGQLDVDLILRCMSDENLPYDLRAS 781

Query: 2539 FTRLMLHLHVVRG--SPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIA 2712
            F RLMLH+HV R     ++ +++ARLW  IP  + +  Y+S      S  S+  I E  A
Sbjct: 782  FCRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDS------SGASKDEIKERFA 835

Query: 2713 HKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLL 2892
             + +  VE YL  +  Q          +KLT+E+VNLA+ L  F FY+F+DLL+LT+ LL
Sbjct: 836  -QTMEFVEEYLRDVVCQRFPFSDK-EKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILL 893

Query: 2893 AIINEGPATEQVPSHR----------------AMVNAIRN-------MSKSMMRGGNKEN 3003
            AI++    T   P  +                   N +R+       M++ ++RGG
Sbjct: 894  AILDCVHVTTIFPISKMAKGEENKGNNDVEKLKSSNVMRSIHGVGELMTQVVLRGGGFLP 953

Query: 3004 SKDLAKTPSVTAEEAGRTKEGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFP 3183
               +A  P    ++A   KE   + + TKL + EILQF+++VR DYRI+  L  FK  F
Sbjct: 954  MTPMAAAPEGNVKQAEPEKED-IMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFD 1012

Query: 3184 -------------CDEDGSLMHSASINERMASELYDAIYRSSGHE--LHLDGRDGQLLLA 3318
                           ++G      +++     E  + I+  S     L LD   G+  L
Sbjct: 1013 ESNSQTSETSSGNSSQEGPSNVPGALDFEHIEEQAEGIFGGSEENTPLDLDDHGGRTFLR 1072

Query: 3319 ILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFIL 3498
            +LL +TM DYPPL S AL++ FRHF+Q QE+L+  KQVQLLV++ DV+NY+QI +DL  L
Sbjct: 1073 VLLHLTMHDYPPLVSGALQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQL 1132

Query: 3499 KNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLN 3678
            +++ EKSELWV+  +      + +D      EH   +     P+  +S  S
Sbjct: 1133 RSIVEKSELWVYKGQG---PDETMDGASGENEHKKTEEGNNKPQKHESTSSYN------- 1182

Query: 3679 EHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKG 3858
                                                     Y +++++L+RL+ +C ++
Sbjct: 1183 -----------------------------------------YRVVKEILIRLSKLCVQES 1201

Query: 3859 DP--KPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKEN 4032
                K     Q+LL+NM  + VVLE + +P++K  D  M +++ L+HEFL++FC  N++N
Sbjct: 1202 ASVRKSRKQQQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQN 1261

Query: 4033 QSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNS 4212
            Q+ L+K I+        +     I E  T+  IF NN +L S + E ++ H V  IE +
Sbjct: 1262 QALLHKHIN--------LFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHG 1313

Query: 4213 RNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKE 4392
            RN  +++ LQ +V    K I+  Q+ V  E+  + ++V   Y D ASF+ L  MM+ E++
Sbjct: 1314 RNVQYIKFLQTIVKAEGKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERD 1373

Query: 4393 SKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVK 4572
                  D    L YHI LV LLA+CT GKN  TE+KC S +P+D IVRVVT + C+ EVK
Sbjct: 1374 ----RMDENSPLMYHIHLVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVK 1429

Query: 4573 TVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDI-RSLRVEKLTGAETATLEHYIC 4749
              Y+  L HCY+DT+ EMK+ Y + ++  +  N L DI R+           + LE Y+
Sbjct: 1430 IAYINFLNHCYVDTEVEMKEIYTSNHMWKLFENFLVDICRACNNTSDRKHADSILEKYVT 1489

Query: 4750 HTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLEL--TYLEKGKLRGSKSSRNWYR 4923
              V  ++  FF +P+S        +   +  F ++L  +   Y     +   K+S
Sbjct: 1490 EIVMSIVTTFFSSPFS---DQSTTLQTRQPVFVQLLQGVFRVYHCNWLMPSQKAS----- 1541

Query: 4924 VAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTL 5103
            V  CI+ L+  A+   I +P  L        + V   + ++ S  +   +  RL+ +N
Sbjct: 1542 VESCIRVLSDVAKSRAIAIPVDL-------DSQVNNLFLKSHSIVQKTAMNWRLSARNAA 1594

Query: 5104 NPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPE 5283
                 L  + +        N++     ++   +  L PL  AE SVLV+VLH PELLFPE
Sbjct: 1595 RRDSVLAASRD------YRNIIERLQDIVSALEDRLRPLVQAELSVLVDVLHRPELLFPE 1648

Query: 5284 GSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKM 5412
             +  R +C  GG + KLI+H K L++  ++ LC +VLQTL +M
Sbjct: 1649 NTDARRKCESGGFICKLIKHTKQLLEENEEKLCIKVLQTLREM 1691



 Score =  617 bits (1592), Expect = e-174
 Identities = 379/1010 (37%), Positives = 553/1010 (54%), Gaps = 30/1010 (2%)
 Frame = +1

Query: 5620 ERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMK 5799
            E  L  +QC L+  GAS+LV D+I+   S  +F ++I LA ALL  GN  +QHSF+ R+
Sbjct: 1797 EMSLAEVQCHLDKEGASNLVIDLIMNASSDRVFHESILLAIALLEGGNTTIQHSFFCRLT 1856

Query: 5800 QKDIHEPFFKAILTRIQTAQNRLKSDM-MSCSDSKPKVSSTVL---TPLIDAGDTGFNGA 5967
            +    E FFK    R++ AQ  +K+ + ++ SD   K     +    P
Sbjct: 1857 EDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPTTQI 1916

Query: 5968 LFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQ---------DEEKSTDALPPEVALVE 6120
              EV  Q+   S +     +     + PD   YQ         D+ K    +   + +++
Sbjct: 1917 TEEVRDQLLEASAATRKAFTTFRREADPD-DHYQPGEGTQATADKAKDDLEMSAVITIMQ 1975

Query: 6121 PILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFG-EIGE 6297
            PILR LQLLCENHN  LQNFLR Q+++TN+NLV ETL FLD +CGST G LG+ G  I E
Sbjct: 1976 PILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINE 2035

Query: 6298 HNFSLITQTLATLTEFCQGPCHENQNTMAMQE-NGLNIIISLVLNEIKPLADDHMELALE 6474
             N +LI QTL +LTE+CQGPCHENQN +A  E NG++II +L+LN              +
Sbjct: 2036 KNVALINQTLESLTEYCQGPCHENQNCIATHESNGIDIITALILN--------------D 2081

Query: 6475 IKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSI 6654
            I     K +  ++E           L+N A+     K L+  ++  ++  N+   +
Sbjct: 2082 INPLGKKRMDLVLE-----------LKNNAS-----KLLLAIMESRHDSENAERILYNMR 2125

Query: 6655 SRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIP 6834
             ++L      ++ KK+  Q  V                            +D  N +D
Sbjct: 2126 PKELV-----EVIKKAYMQGEVE--------------------------FEDGENGED-G 2153

Query: 6835 SVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRD 7014
            +  PR VGHNIYILAHQLA H+ EL+  L    +   D   EAL +Y + TAQIEIVR D
Sbjct: 2154 AASPRNVGHNIYILAHQLARHNKELQSMLKPGGQVDGD---EALEFYAKHTAQIEIVRLD 2210

Query: 7015 RTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQD 7194
            RT+E++VFP+  IC +LTK++K  +Y  TERD QGSK+ +FF   E +++EM WQ+KL+
Sbjct: 2211 RTMEQIVFPVPSICEFLTKESKLRIYYTTERDEQGSKINDFFLRSEDLFNEMNWQKKLRA 2270

Query: 7195 RKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSIS---LGNLYSWFAVFSS 7365
            +  L WCA  +  W+ +SF+ A ++N LVA +YP       ++     G L++   +  +
Sbjct: 2271 QPVLYWCARNMSFWSSISFNLAVLMNLLVAFFYPFKGVRGGTLEPHWSGLLWTAMLISLA 2330

Query: 7366 FLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVAFVSN 7545
             ++A    H                       +G+  TL++ G   + NKI+ +++FV N
Sbjct: 2331 IVIALPKPHG-------IRALIASTILRLIFSVGLQPTLFLLGAFNVCNKIIFLMSFVGN 2383

Query: 7546 KGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVT 7725
             G   R    ++      Y L+YL IC +GL VH   Y +LLFD+++ EETL NVI SVT
Sbjct: 2384 CGTFTRGYRAMVLDVEFLYHLLYLVICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVT 2443

Query: 7726 RNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSS------ATISSGIPSE 7887
            RN +SI+ T +LALIL+Y FSI+G+L+F+ DF LEVD + N+++      +  S  + S+
Sbjct: 2444 RNGRSIILTAVLALILVYLFSIVGYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSD 2503

Query: 7888 TC---PSEGCPGLQPSXX---XXXXXXXXXXSCETLWMCILQTGYQGLRNGGGIGDVLRN 8049
             C     E C    P                +CETL MCI+     GLR+GGG+GDVLR
Sbjct: 2504 VCRVESGENCSSPAPREELVPAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRK 2563

Query: 8050 PAPWEDMFIWRVAYDMTXXXXXXXXXXXXXXXXXXDTFGDLRAEKNEKEQILKNNCFICG 8229
            P+  E +F  RV YD+                   DTF DLR+EK +KE+ILK  CFICG
Sbjct: 2564 PSKEEPLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICG 2623

Query: 8230 LDRSRFDNRSVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWF 8409
            L+R +FDN++VTFE H + EHN+WHYL +IV++++KD TE+TGPESYVA+ +K+RNLDWF
Sbjct: 2624 LERDKFDNKTVTFEEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWF 2683

Query: 8410 PRMQALSLQDSELDTDQSEVKQMKDQLLQMMTLMREIISQNEESRAFMEQ 8559
            PRM+A+SL  S+ + +Q+E++ ++++L   M L+  +  Q  E +  M +
Sbjct: 2684 PRMRAMSLVSSDSEGEQNELRNLQEKLESTMKLVTNLSGQLSELKDQMTE 2733


>gi|111839|pir||B36579 inositol 1,4,5-triphosphate receptor 2 - rat
 gi|204674|gb|AAA41357.1| inositol-1,4,5-triphosphate receptor
          Length = 2734

 Score = 1053 bits (2722), Expect = 0.0
 Identities = 679/1833 (37%), Positives = 996/1833 (54%), Gaps = 65/1833 (3%)
 Frame = +1

Query: 109  LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
            LHIGDI SLY E S+N    GF+STLGLVDDRC+V+ + G   +PPKKFRDCLFK+CP+N
Sbjct: 9    LHIGDICSLYAEGSTN----GFISTLGLVDDRCVVQPEAGDLNNPPKKFRDCLFKLCPMN 64

Query: 289  RYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQ 468
            RY+AQK  W   K     +S  D  L+NKL  AAD E+++NE+E +K LG VIQYG+++Q
Sbjct: 65   RYSAQKQFWKAAK--PGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQ 122

Query: 469  LLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKI 648
            LLH+KSNKY+TV K  PA  E+NAM+V LD AGNEGSWF I+P YK  +IGD+V  G+K+
Sbjct: 123  LLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGDKV 182

Query: 649  SLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSV 828
             L P       AG     LH SS  L+D+    EVN +N  T W++ +F+ + +N+ + +
Sbjct: 183  VLNP-----VNAGQ---PLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDIL 234

Query: 829  KSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTN 1008
            K GDVVRLFHA+Q+ FLT D   K+      VFLR T R SA  ATSS+ALWEV+VVQ +
Sbjct: 235  KGGDVVRLFHAEQEKFLTCDEHRKKQH----VFLRTTGRQSATSATSSKALWEVEVVQHD 290

Query: 1009 AYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRPPLLSALSQKSRPMLERTNN 1188
              RGG   WN  +RFKHLAT  YL+AE    Q                  SR  L
Sbjct: 291  PCRGGAGYWNSLFRFKHLATGHYLAAEVDPDQ----------------DASRSRLRNAQE 334

Query: 1189 PMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPE-EDANLLFQLDPSTFMKSNKE 1365
             M +YS                 + SV          PE  D + +F+LDP+T    +
Sbjct: 335  KM-VYS-----------------LVSV----------PEGNDISSIFELDPTTLRGGDSL 366

Query: 1366 VPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKG-WVKVICEKNRVDKETFALLPV 1542
            VPR SYVRL H  ++ WVH+TN      +    + EK   +K+     + DKE FA++PV
Sbjct: 367  VPRNSYVRLRHLCTNTWVHSTN------IPIDKEEEKPVMLKIGTSPLKEDKEAFAIVPV 420

Query: 1543 NPDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADP 1722
            +P EVRDLDFANDA K L +    ++ G +   E   S T+LL D + FVT  ++   D
Sbjct: 421  SPAEVRDLDFANDASKVLGSIAGKLEKGTITQNER-RSVTKLLEDLVYFVTGGTNSGQDV 479

Query: 1723 LKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIF 1902
            L++    P+R+RQKL+REQ +L Q+F LL+APF     T              D R+  F
Sbjct: 480  LEVVFSKPNRERQKLMREQNILKQIFKLLQAPF-----TDCGDGPMLRLEELGDQRHAPF 534

Query: 1903 KTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKY 2082
            + + +LCY +L++SQ  YRKNQE++A++FG +Q+QIG+D++AEDT+TA+LHNN KLLEK+
Sbjct: 535  RHICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKH 594

Query: 2083 VKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTK 2262
            +    ++ FV LVR NR+ +FLDYL+DLCV   ++    QELIC +VL+  + DI ++TK
Sbjct: 595  ITAAEIDTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETK 654

Query: 2263 II---------------------DGEIEVGWAPNFRKL-----VDIAEGAK-SNSDDAEH 2361
            ++                     + E+ + W  + +++      ++A+ AK    +D +
Sbjct: 655  LVLSRFEFEGVSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDAKEGQKEDRDV 714

Query: 2362 LDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSF 2541
            L YYR+QL+L ++MC ++QYLAI+         IS QL  +L+L+CMSD  LPYDLR SF
Sbjct: 715  LSYYRYQLNLFARMCLDRQYLAIN--------EISGQLDVDLILRCMSDENLPYDLRASF 766

Query: 2542 TRLMLHLHVVRG--SPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAH 2715
             RLMLH+HV R     ++ +++ARLW  IP  + +  Y+S      S  S+  I E  A
Sbjct: 767  CRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDS------SGASKDEIKERFA- 819

Query: 2716 KVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLA 2895
            + +  VE YL  +  Q          +KLT+E+VNLA+ L  F FY+F+DLL+LT+ LLA
Sbjct: 820  QTMEFVEEYLRDVVCQRFPFSDK-EKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLA 878

Query: 2896 IINEGPATEQVPSHRAM-------VNAIRN-------MSKSMMRGGNKENSKDLAKTPSV 3033
            I++    T   P  +          N +R+       M++ ++RGG       +A  P
Sbjct: 879  ILDCVHVTTIFPISKMTKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEG 938

Query: 3034 TAEEAGRTKEGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFP---------- 3183
              ++A   KE   + + TKL + EILQF+++VR DYRI+  L  FK  F
Sbjct: 939  NVKQAEPEKED-IMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQSSETS 997

Query: 3184 ---CDEDGSLMHSASINERMASELYDAIYRSSGHE--LHLDGRDGQLLLAILLQMTMSDY 3348
                 ++G      +++     E  + I+  S     L LD   G+  L +LL +TM DY
Sbjct: 998  SGNSSQEGPSNVPGALDFEHIEEQAEGIFGGSEENTPLDLDDHGGRTFLRVLLHLTMHDY 1057

Query: 3349 PPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELW 3528
            PPL S AL++ FRHF+Q QE+L+  KQVQLLV++ DV+NY+QI +DL  L+++ EKSELW
Sbjct: 1058 PPLVSGALQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELW 1117

Query: 3529 VHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNEC 3708
            V+  +      + +D      EH   +     P   +S  S
Sbjct: 1118 VYKGQG---PDEPMDGASGENEHKKTEEGTSKPLKHESTSSYN----------------- 1157

Query: 3709 LQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDP--KPDTMN 3882
                                           Y +++++L+RL+ +C ++     K
Sbjct: 1158 -------------------------------YRVVKEILIRLSKLCVQESASVRKSRKQQ 1186

Query: 3883 QQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFISY 4062
            Q+LL+NM  + VVLE + +P++K  D  M +++ L+HEFL++FC  N++NQ+ L+K I+
Sbjct: 1187 QRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHIN- 1245

Query: 4063 EKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQ 4242
                   +     I E  T+  IF NN +L S + E ++ H V  IE + RN  +++ LQ
Sbjct: 1246 -------LFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQ 1298

Query: 4243 ALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSDSRR 4422
             +V    K I+  Q+ V  E+  + ++V   Y D ASF+ L  MM+ E++   R  ++
Sbjct: 1299 TIVKAEGKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERD---RMDENSP 1355

Query: 4423 KLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHC 4602
               YHI LV LLA+CT GKN  TE+KC S +P+D IVRVVT + C+ EVK  Y+  L HC
Sbjct: 1356 LFMYHIHLVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHC 1415

Query: 4603 YIDTDAEMKDAYKTEYVDHILNNLLEDI-RSLRVEKLTGAETATLEHYICHTVTEVLIKF 4779
            Y+DT+ EMK+ Y + ++  +  N L DI R+           + LE Y+   V  ++  F
Sbjct: 1416 YVDTEVEMKEIYTSNHMWKLFENFLVDICRACNNTSDRKHADSVLEKYVTEIVMSIVTTF 1475

Query: 4780 FEAPYSALQQAKVDVHHHKKTFSEVLLEL--TYLEKGKLRGSKSSRNWYRVAECIKRLTK 4953
            F +P+S        +   +  F ++L  +   Y     +   K+S     V  CI+ L+
Sbjct: 1476 FSSPFS---DQSTTLQTRQPVFVQLLQGVFRVYHCNWLMPSQKAS-----VESCIRVLSD 1527

Query: 4954 WAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGHRLYGTS 5133
             A+   I +P  L        + V   + ++ +  +   +  RL+ +N       L  +
Sbjct: 1528 VAKSRAIAIPVDL-------DSQVNNLFLKSHNIVQKTAMNWRLSARNAARRDSVLAASR 1580

Query: 5134 NSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCAR 5313
            +        N++     ++   +  L PL  AE SVLV+VLH PELLFPE +  R +C
Sbjct: 1581 D------YRNIIERLQDIVSALEDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKCES 1634

Query: 5314 GGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKM 5412
            GG + KLI+H K L++  ++ LC +VLQTL +M
Sbjct: 1635 GGFICKLIKHTKQLLEENEEKLCIKVLQTLREM 1667



 Score =  613 bits (1582), Expect = e-173
 Identities = 376/1010 (37%), Positives = 551/1010 (54%), Gaps = 30/1010 (2%)
 Frame = +1

Query: 5620 ERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMK 5799
            E  L  +QC L+  GAS+LV D+I+   S  +F ++I LA ALL  GN  +QHSF+ R+
Sbjct: 1773 EMSLAEVQCHLDKEGASNLVIDLIMNASSDRVFHESILLAIALLEGGNTTIQHSFFCRLT 1832

Query: 5800 QKDIHEPFFKAILTRIQTAQNRLKSDM-MSCSDSKPKVSSTVL---TPLIDAGDTGFNGA 5967
            +    E FFK    R++ AQ  +K+ + ++ SD   K     +    P
Sbjct: 1833 EDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPTTQI 1892

Query: 5968 LFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQ---------DEEKSTDALPPEVALVE 6120
              EV  Q+   S +     +     + PD   YQ         D+ K    +   + +++
Sbjct: 1893 TEEVRDQLLEASAATRKAFTTFRREADPD-DHYQSGEGTQATTDKAKDDLEMSAVITIMQ 1951

Query: 6121 PILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFG-EIGE 6297
            PILR LQLLCENHN  LQNFLR Q+++TN+NLV ETL FLD +CGST G LG+ G  I E
Sbjct: 1952 PILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINE 2011

Query: 6298 HNFSLITQTLATLTEFCQGPCHENQNTMAMQE-NGLNIIISLVLNEIKPLADDHMELALE 6474
             N +LI QTL +LTE+CQGPCHENQN +A  E NG++II +L+LN              +
Sbjct: 2012 KNVALINQTLESLTEYCQGPCHENQNCIATHESNGIDIITALILN--------------D 2057

Query: 6475 IKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSI 6654
            I     K +  ++E           L+N A+     K L+  ++  ++  N+   +
Sbjct: 2058 INPLGKKRMDLVLE-----------LKNNAS-----KLLLAIMESRHDSENAERILYNMR 2101

Query: 6655 SRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIP 6834
             ++L      ++ KK+  Q  V                            +D  N +D
Sbjct: 2102 PKELV-----EVIKKAYMQGEVE--------------------------FEDGENGED-G 2129

Query: 6835 SVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRD 7014
            +  PR VGHNIYILAHQLA H+ EL+  L    +   D   EAL +Y + TAQIEIVR D
Sbjct: 2130 AASPRNVGHNIYILAHQLARHNKELQTMLKPGGQVDGD---EALEFYAKHTAQIEIVRLD 2186

Query: 7015 RTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQD 7194
            RT+E++VFP+  IC +LTK++K  +Y  TERD QGSK+ +FF   E +++EM WQ+KL+
Sbjct: 2187 RTMEQIVFPVPSICEFLTKESKLRIYYTTERDEQGSKINDFFLRSEDLFNEMNWQKKLRA 2246

Query: 7195 RKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSIS---LGNLYSWFAVFSS 7365
            +  L WCA  +  W+ +SF+ A ++N LVA +YP       ++     G L++   +  +
Sbjct: 2247 QPVLYWCARNMSFWSSISFNLAVLMNLLVAFFYPFKGVRGGTLEPHWSGLLWTAMLISLA 2306

Query: 7366 FLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVAFVSN 7545
             ++A    H                       +G+  TL++ G   + NKI+ +++FV N
Sbjct: 2307 IVIALPKPHG-------IRALIASTILRLIFSVGLQPTLFLLGAFNVCNKIIFLMSFVGN 2359

Query: 7546 KGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVT 7725
             G   R    ++      Y L+YL IC +GL VH   Y +LLFD+++ EETL NVI SVT
Sbjct: 2360 CGTFTRGYRAMVLDVEFLYHLLYLLICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVT 2419

Query: 7726 RNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSS------ATISSGIPSE 7887
            RN + I+ T  LALIL+Y FSI+G+L+F+ DF LEVD + N+++      +  +  + S+
Sbjct: 2420 RNGRPIILTAALALILVYLFSIVGYLFFKDDFILEVDRLPNETAGPETGESLANDFLYSD 2479

Query: 7888 TC---PSEGCPGLQPSXXXX---XXXXXXXXSCETLWMCILQTGYQGLRNGGGIGDVLRN 8049
             C     E C    P                +CETL MCI+     GLR+GGG+GDVLR
Sbjct: 2480 VCRVETGENCTSPAPKEELLPVEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRK 2539

Query: 8050 PAPWEDMFIWRVAYDMTXXXXXXXXXXXXXXXXXXDTFGDLRAEKNEKEQILKNNCFICG 8229
            P+  E +F  RV YD+                   DTF DLR+EK +KE+ILK  CFICG
Sbjct: 2540 PSKEEPLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICG 2599

Query: 8230 LDRSRFDNRSVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWF 8409
            L+R +FDN++VTFE H + EHN+WHYL +IV++++KD TE+TGPESYVA+ +++RNLDWF
Sbjct: 2600 LERDKFDNKTVTFEEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIRERNLDWF 2659

Query: 8410 PRMQALSLQDSELDTDQSEVKQMKDQLLQMMTLMREIISQNEESRAFMEQ 8559
            PRM+A+SL  S+ + +Q+E++ ++++L   M L+  +  Q  E +  M +
Sbjct: 2660 PRMRAMSLVSSDSEGEQNELRNLQEKLESTMKLVTNLSGQLSELKDQMTE 2709


>gi|47219802|emb|CAG03429.1| unnamed protein product [Tetraodon
            nigroviridis]
          Length = 2747

 Score =  976 bits (2523), Expect = 0.0
 Identities = 658/1839 (35%), Positives = 971/1839 (52%), Gaps = 69/1839 (3%)
 Frame = +1

Query: 109  LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
            LHIGDI+SLY E S N    GF+STLGLVDDRC+V+   G   +PPKKFRDCLFKVCP+N
Sbjct: 9    LHIGDIVSLYAEGSVN----GFISTLGLVDDRCVVQPDAGDLANPPKKFRDCLFKVCPMN 64

Query: 289  RYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQ 468
            RY+AQK  W + K+ + G+S    DL  KL+ AA+ E+++NESE +K LG V++Y +++Q
Sbjct: 65   RYSAQKQFW-KAKQGKQGNSNTQGDLFKKLQHAAELEQKQNESENKKLLGEVVKYSNVIQ 123

Query: 469  LLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKI 648
            LLH+KSNK++TV K  PA  E+NAM+V LD AGNEGSWF I+P +K  + GDNV  G+K+
Sbjct: 124  LLHIKSNKFLTVNKRLPALLEKNAMRVSLDPAGNEGSWFYIQPFWKLRSEGDNVVVGDKV 183

Query: 649  SLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSV 828
             L+P       AG     LH S+  LLD+    EVN +N  T W++ +F+ F + +++ +
Sbjct: 184  VLMP-----VNAGQ---PLHASNIELLDNPGCKEVNAVNCNTSWKITLFMKFSDYKEDVL 235

Query: 829  KSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTN 1008
            K GDVVRLFHA+Q+ FLT D   +Q      VFLR T R SA  ATSS+ALWEV+VV  +
Sbjct: 236  KGGDVVRLFHAEQEKFLTCDEHRRQQH----VFLRTTLRQSATSATSSKALWEVEVVHYD 291

Query: 1009 AYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRPPLLSALSQKSRPMLERTNN 1188
              RGG  +WN  +RFKHLAT  YL+AE     V P              K      R  N
Sbjct: 292  PCRGGAGQWNSLFRFKHLATGNYLAAE-----VNPEF------------KDNTTAPRGEN 334

Query: 1189 PMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEV 1368
               +          E    T  ++P               D   LF+LD +T  +++  V
Sbjct: 335  ETDVVFSKRKHQAAEKITFTLVSVPH------------GNDIASLFELDATTLQRADCLV 382

Query: 1369 PRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWVKVICEKNRVDKETFALLPVNP 1548
            PR SYVRL H  ++ WV +TN         + +     +K+     + DKE FA++ V
Sbjct: 383  PRNSYVRLRHLCTNTWVTSTNVPID-----TEEERPVMLKIGTCPAKEDKEAFAIVSVPL 437

Query: 1549 DEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADPLK 1728
             EVRDLDFANDA K L + ++ ++ G +   E     T+LL D + FV    ++  D L
Sbjct: 438  SEVRDLDFANDASKVLESTVRKLQYGTITQNER-RFVTKLLEDLVFFVCVVPNNGQDVLS 496

Query: 1729 ISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIFKT 1908
            +   +P+R+RQKL+REQ +L Q+F +LKAPF     T              D R   FK
Sbjct: 497  VVTSTPNRERQKLMREQNILAQIFGILKAPF-----TDQGDGPILRLEDLGDQRYAHFKY 551

Query: 1909 MFQLCYCLLKYSQVSYRKNQ--------------EFLAEKFGEIQEQIGFDLMAEDTMTA 2046
            M +LCY +L++SQ  YRKNQ              E++A+KF  +Q QIG++++AEDT+TA
Sbjct: 552  MLRLCYRVLRHSQQDYRKNQAGVVAIMWSFSALQEYIAKKFTIMQSQIGYEILAEDTITA 611

Query: 2047 VLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVL 2226
            +LHNN KLLEK++    +E FV L+R NR+ +FLDYL+DLCV    A    QELIC  +L
Sbjct: 612  LLHNNRKLLEKHITAREIETFVNLLRRNREPRFLDYLSDLCVSNKTAIPVTQELICKFML 671

Query: 2227 SSKHRDIFMDTKII-----------------DGEIEVGW-----APNFRKLVDIAEGAKS 2340
            +  + DI + TK+I                 + E+ + W      P+ + +  +A+ AK
Sbjct: 672  NPTNADILIQTKLIANTETTLESSLLQEEVEEEEVWLYWIDSHKEPHGKSIRHLAQDAKG 731

Query: 2341 -NSDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRL 2517
             +  D + + YYR+QL+L ++MC ++QYLAI+         +S QLP +L+L+CM D+ L
Sbjct: 732  IHKMDVDIITYYRYQLNLFAKMCLDRQYLAIN--------QVSCQLPVDLILRCMFDDCL 783

Query: 2518 PYDLRGSFTRLMLHLHVVRGSPMSA--IRHARLWWSIPENVNVSTYESVSVEAYSDGSRM 2691
            PY+LR SF RLMLH+HV R    S   +R+ARLW  IP  + +  +E  S    +D SR
Sbjct: 784  PYNLRASFCRLMLHMHVDRDPQESVVPVRYARLWTEIPSKITIHEFEYES----TDTSRE 839

Query: 2692 RIGEGIAHKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLL 2871
             +    A   +  VE YL  + +Q        + ++LT E+VNLA+ L  F FYSF++LL
Sbjct: 840  EMKRKFA-PTMEFVEEYLRDVVSQPFPFGDK-DKNELTLEVVNLARNLVYFGFYSFSELL 897

Query: 2872 QLTQNLLAI-------------INEGPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKD 3012
            +LT+ LLAI             +N+ P  E   +    ++ +  M   M+      +S
Sbjct: 898  RLTRTLLAILDIVQHPLSLINKLNKSP--EAGNNVLRTIHGVGEMMTQMVMSRGVPHS-- 953

Query: 3013 LAKTPSVTAEEAGR--TKEGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFPC 3186
            L  TP       G   +     + + TKL + EILQF++ VR DYRIT  LS +K  F
Sbjct: 954  LTDTPPSLRYGKGYFFSDNEDVMVMDTKLKIIEILQFILSVRLDYRITYLLSIYKKEFGD 1013

Query: 3187 D---EDGSLMHSASINERMASE--------LYDAIYRSSGH--ELHLDGRDGQLLLAILL 3327
            +   E+     S  +    ASE          + ++  S     + LD   G+  L +L+
Sbjct: 1014 NSIVENSMADCSTMLLFTPASEPDIDEITTKAETMFAGSSELSAVELDDEGGRTFLRVLI 1073

Query: 3328 QMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNL 3507
             + M +YPPL S +L++ F+HF+Q  E+L+  KQVQLLVS  DVENY+QI  DL  L+
Sbjct: 1074 HLIMQEYPPLVSGSLQLLFKHFSQRAEVLQAFKQVQLLVSEQDVENYKQIKTDLDQLRLT 1133

Query: 3508 TEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHY 3687
             EKSELWV     ++ +   V + +   E  +L     SP
Sbjct: 1134 VEKSELWVEKSGAYNGEDLAVRQGKEPNEEGVL-----SP-------------------- 1168

Query: 3688 PSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDPK 3867
                           ++D  N   +   + ++      Y +++++L+RL+ +CY     K
Sbjct: 1169 ---------------VQDGDNKPQIDSNKANN------YKIVKEILLRLSKLCY--PSKK 1205

Query: 3868 PDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLY 4047
                 Q+LLKNM  + VVL+ + +P++K  D  M +++TL+H FL++FC+ N +NQ  L+
Sbjct: 1206 SRVQQQRLLKNMGAHTVVLDLLQIPYEKS-DEKMNEIMTLAHTFLQNFCRGNPQNQVLLH 1264

Query: 4048 KFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIF 4227
            K ++       G+L  ET+        IF NN +L + + + ++ H V  IE + ++  +
Sbjct: 1265 KHLNL--FLTPGLLEAETMRH------IFMNNYQLCNEISDRVVHHFVHCIETHGKHVQY 1316

Query: 4228 LELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRS 4407
            L+ L+ +V    K ++  Q+KV  E+    ++V   Y D +SF  L  MM  E+E
Sbjct: 1317 LKFLETIVKADGKYVKKCQDKVMTELVNGGEDVLVFYNDRSSFPVLLQMMGSERE----R 1372

Query: 4408 SDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQ 4587
            +D    L YH  LV LLA CT GKN  TELKC S +P+D IVRVVT   C+ EVKT Y+
Sbjct: 1373 TDEDGALAYHNTLVELLAACTEGKNVYTELKCNSLLPLDDIVRVVTDIHCVPEVKTAYVN 1432

Query: 4588 LLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSL--RVEKLTGAETATLEHYICHTVT 4761
             + HCY+DT+ EMK+ Y + ++  + +N L D+ S      +   A++A LE Y+  TV
Sbjct: 1433 FVNHCYVDTEVEMKEIYTSNHIWKLFDNFLVDMSSACNTTTERNHADSA-LEKYVTETVM 1491

Query: 4762 EVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGKLRGSKSSRNWYRVAECIK 4941
             ++  FF +P+S       ++  ++  F ++L     +       +    N   +  CIK
Sbjct: 1492 AIVKGFFSSPFSV---NHANLQTNQSIFIKLLQSSFRIYNCTWLSAPQKAN---IESCIK 1545

Query: 4942 RLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGHRL 5121
             L   A+   I +P  L     +    V     Q A+         R  ++    P +R
Sbjct: 1546 TLADVAKARAIAIPVDLDSQVNTLSLKVHSTMVQRAAKDWRTSARSRPRKEPLGGPDYR- 1604

Query: 5122 YGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRD 5301
                         N++     ++   +    P   AE SVLV+VLH+PELLFPE + L
Sbjct: 1605 -------------NIIEKLQGVVSLLEEQFSPKVQAEFSVLVDVLHSPELLFPEAAQL-- 1649

Query: 5302 QCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCD 5418
             C  G  ++KLI+H K LM +K++ LC ++LQTL +M D
Sbjct: 1650 -CESGAFMSKLIKHTKKLM-DKEEKLCIKILQTLREMLD 1686



 Score =  613 bits (1582), Expect = e-173
 Identities = 353/871 (40%), Positives = 500/871 (56%), Gaps = 49/871 (5%)
 Frame = +1

Query: 6094 LPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSL 6273
            + P +A+++PILR LQLLCENHNS LQNFLR Q+++TN+NLV ETL FLD +CGST G L
Sbjct: 1904 MSPAIAIMKPILRFLQLLCENHNSELQNFLRNQNNKTNYNLVCETLQFLDCICGSTTGGL 1963

Query: 6274 GVFG-EIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQE-NGLNIIISLVLNEIKPLA 6447
            G+ G  I E N  LI QTL T+TE+CQGPCHENQ  +A  E NG++III+L++N I PL
Sbjct: 1964 GLLGLYINESNVDLIRQTLETITEYCQGPCHENQTCIAKHESNGIDIIIALIVNPINPLG 2023

Query: 6448 DDHMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTN 6627
             + ++L LE+K+ ASKLLLAIMESRHD ENA ++L  M      P +LV    +A+
Sbjct: 2024 KNRLDLVLELKNNASKLLLAIMESRHDSENAEKILYKMR-----PNELVGEQVRAHTWAG 2078

Query: 6628 SNHHMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLD 6807
            ++                        P +T+  V   ++  +A      +T+   S   D
Sbjct: 2079 AD------------------------PVLTLACVAQVDVMKEA------YTQGLQSEEED 2108

Query: 6808 DKFNDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWL---DGSDEKKDDLTREALNYYK 6978
            D   D     + PR+VGHNIYILAHQLA H   L+  L    GS    D+   +AL+YY
Sbjct: 2109 DGVGDQ----IKPRDVGHNIYILAHQLARHSKVLQQSLKPGSGSPFDPDNEKDDALHYYA 2164

Query: 6979 ERTAQIEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETM 7158
              TAQIEIVRRDRT+E++VFP+ +IC YLT+++   V+  TERD+QGSKV +FF +++ +
Sbjct: 2165 NHTAQIEIVRRDRTMEQIVFPVPNICEYLTEESMVRVFTTTERDDQGSKVNDFFQQFDNL 2224

Query: 7159 YHEMIWQRKLQDRKW----------------------------------------LSWCA 7218
            Y+EM WQ+K++ +                                          L W +
Sbjct: 2225 YNEMRWQKKIRSKASYTESTSCQMVMAVTGGGQSRLTVVVPDDELLFAVYAENIALFWFS 2284

Query: 7219 FRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSI--SLGNLYSWFAVFSSFLLAHYLRH 7392
              + LW  +SF+ A +VN  VA +YP  +  +        N+  W A+    +L   L
Sbjct: 2285 RNISLWGSISFYLACLVNIAVAVFYPFGDDGDEGTLSPFWNILLWVALGVFSILLPVLPK 2344

Query: 7393 DKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIA 7572
             +  L                  +G+   L + G   L NK+V +V+FV N+G   R
Sbjct: 2345 PQGILF-----FLVSLILRSIYTLGLGPALLLLGTSNLFNKLVFLVSFVGNQGTFTRGYK 2399

Query: 7573 EILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIVWT 7752
             ++      Y + Y  IC+LGLLVH   Y  LLFD++  EETL NVI SVTRN +SI+ T
Sbjct: 2400 AVVMDMLFIYHMSYAIICVLGLLVHEFFYSFLLFDLVIREETLLNVIKSVTRNGRSIILT 2459

Query: 7753 GLLALILLYFFSILGFLYFRHDFYLEVD--PVENDSSATISSGIPSETCPSEGCPGLQPS 7926
             +LAL L+YFFSI+GFL+ + DF +EVD  P         +  IP E   +E C     +
Sbjct: 2460 AILALFLVYFFSIIGFLFLKDDFRMEVDRLPAPEIKDLFKNQKIP-EAYSNEIC-----T 2513

Query: 7927 XXXXXXXXXXXXSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTXX 8106
                         C+TL+MCI+    QGLRNGGG+GD+LR P+  E +F  RV YD+
Sbjct: 2514 KPVADEDDGMERVCDTLFMCIITVLNQGLRNGGGVGDILRRPSKAEPLFAARVVYDLLFF 2573

Query: 8107 XXXXXXXXXXXXXXXXDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRET 8286
                            DTF DLR+EK  KE+ILK  CFICGL+R +FDN++VTFE H ++
Sbjct: 2574 FVVIIIVLNLIFGVIIDTFADLRSEKQRKEEILKTTCFICGLERDKFDNKTVTFEEHIKS 2633

Query: 8287 EHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSE 8466
            EHN+WHYLY++V++++KD TE+TGPESYVAQ + ++NL+WFPRM+A+SL  +E + +Q+E
Sbjct: 2634 EHNMWHYLYFLVLVRVKDPTEYTGPESYVAQMIAEKNLEWFPRMRAMSLVSNEGEGEQNE 2693

Query: 8467 VKQMKDQLLQMMTLMREIISQNEESRAFMEQ 8559
            ++ ++++L   +TL+ ++ +Q  E +  M +
Sbjct: 2694 MRCLQEKLSDTVTLVAQLSAQLSELKEQMTE 2724


>gi|50754604|ref|XP_414438.1| PREDICTED: similar to inositol
            1,4,5-trisphosphate receptor type 1 [Gallus gallus]
          Length = 3466

 Score =  918 bits (2372), Expect = 0.0
 Identities = 644/1845 (34%), Positives = 947/1845 (50%), Gaps = 128/1845 (6%)
 Frame = +1

Query: 262  CLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGN 441
            CLFK+CP+NRY+AQK  W   K     +S  D  L+NKL  AAD E+++NE+E +K LG
Sbjct: 743  CLFKLCPMNRYSAQKQFWKAAK--PGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGT 800

Query: 442  VIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIG 621
            VIQYG+++QLLH+KSNKY+TV K  PA  E+NAM+V LD AGNEGSWF I+P YK  +IG
Sbjct: 801  VIQYGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIG 860

Query: 622  DNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLL 801
            D+V  G+K+ L P       AG     LH SS  L+D+    EVN +N  T W++ +F+
Sbjct: 861  DSVVIGDKVVLNP-----VNAG---QPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMK 912

Query: 802  FDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRAL 981
            + +N+ + +K GDVVRLFHA+Q+ FLT D   K+      VFLR T R SA  ATSS+AL
Sbjct: 913  WSDNKDDILKGGDVVRLFHAEQEKFLTCDEHRKKQH----VFLRTTGRQSATSATSSKAL 968

Query: 982  WEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRPPLLSALSQKS 1161
            WEV+VVQ +  RGG   WN  +RFKHLAT  YL+AE +
Sbjct: 969  WEVEVVQHDPCRGGAGYWNSLFRFKHLATGHYLAAEVN---------------------- 1006

Query: 1162 RPMLERTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANLLFQLDPS 1341
             P  E  +       D     +     + Q+ +    V  P  +     D + +F+LDP+
Sbjct: 1007 -PDYEEDDQECQSSQDPEQDASRRGLRSAQEKMAYSLVSVPEGN-----DISSIFELDPT 1060

Query: 1342 TFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKG-WVKVICEKNRVDK 1518
            T    +  VPR SYVRL H  ++ WVH+T      N+    + EK   +K+     + DK
Sbjct: 1061 TLRGGDSLVPRNSYVRLRHLCTNTWVHST------NIPIDKEEEKPVMLKIGTSPVKEDK 1114

Query: 1519 ETFALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTN 1698
            E FA++PV+P EVRDLDFANDA K L +    ++ G +   E   S T+LL D + FVT
Sbjct: 1115 EAFAIVPVSPAEVRDLDFANDASKVLGSIAGKLEKGTITQNER-RSVTKLLEDLVYFVTG 1173

Query: 1699 SSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXX 1878
             ++   D L++    P+R+RQKL+REQ +L Q+F LL+APF     T
Sbjct: 1174 GTNSGQDVLEVVFSKPNRERQKLMREQNILKQIFKLLQAPF-----TDSGDGPMLRLEEL 1228

Query: 1879 XDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHN 2058
             D R+  F+ + +LCY             +E++A++FG +Q+QIG+D++AEDT+TA+LHN
Sbjct: 1229 GDQRHAPFRHICRLCY-------------REYIAKQFGFMQKQIGYDVLAEDTITALLHN 1275

Query: 2059 NPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKH 2238
            N KLLEK++    ++ FV LVR NR+ +FLDYL+DLCV   ++    QELIC +VL+  +
Sbjct: 1276 NRKLLEKHITAAEIDTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPAN 1335

Query: 2239 RDIFMDTKII------------DGEIEVG---------WAPN-----FRKLVDIAEGAK- 2337
             DI ++TK++            +  +EVG         W  +      + + ++A+ AK
Sbjct: 1336 ADILIETKLVLSRFEFEEVSSGENALEVGEDEEEVWLFWRDSNKEIRSKSIRELAQDAKE 1395

Query: 2338 SNSDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRL 2517
               +D + L YYR+QL+L ++MC ++QYLAI+         IS QL  +L+L+CMSD  L
Sbjct: 1396 GQKEDRDVLSYYRYQLNLFARMCLDRQYLAIN--------EISGQLDVDLILRCMSDENL 1447

Query: 2518 PYDLRGSFTRLMLHLHVVRG--------------SPMSAI---------RHARLWWSIPE 2628
            PYDLR SF RLMLH+HV R               +  SAI         +    W
Sbjct: 1448 PYDLRASFCRLMLHMHVDRDPQEQSSDSSKLIVHTAASAINSRNKGKMQKQVMCWIQSCC 1507

Query: 2629 NVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATVETYLMGLRNQSMEERQSVNSSKLTY 2808
             +    Y+S      S  S+  I E  A + +  VE YL  +  Q          +KLT+
Sbjct: 1508 LIANGNYDS------SGTSKDEIKERFA-QTMEFVEEYLRDVVCQRFPFSDK-EKNKLTF 1559

Query: 2809 EIVNLAKALAQFNFYSFNDLLQLTQNLLAIIN--------------EGPATEQVPSHRAM 2946
            E+VNLA+ L  F FY+F DLL+LT+ LLAI++              +G  ++     R++
Sbjct: 1560 EVVNLARNLIYFGFYNFCDLLRLTKILLAILDCVHITTIFPITKMAKGEESKGSNVMRSI 1619

Query: 2947 VNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKTKLIVAEILQFVMD 3126
                  M++ ++RGG       LA  P    ++    KE   L + TKL + EILQF+++
Sbjct: 1620 HGVGELMTQVVLRGGGFLPMTPLAAAPEGNVKQTEPEKED-ILVMDTKLKIIEILQFILN 1678

Query: 3127 VRRDYRITMALSWFKNVFPCDEDGSLMH---SASINERMASELYDAI------------- 3258
            VR DYRI+  L  FK+ F  DE  + M    + S ++ M + +  A+
Sbjct: 1679 VRLDYRISCLLCIFKHEF--DESNAQMSESPTGSSSQEMPANVPGALDFEHIEEQAEGIF 1736

Query: 3259 --YRSSGHE----LHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLED 3420
               + S HE    L LD   G+  L +LL +TM DYPPL S AL++ FRHF+Q QE+L+
Sbjct: 1737 GGRKVSLHEENTPLDLDDHGGRTFLRVLLHLTMHDYPPLVSGALQLLFRHFSQRQEVLQA 1796

Query: 3421 LKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHD 3600
             KQVQLLV++ DV+NY+QI +DL  L+++ EKSELWV+  +      + +D      EH
Sbjct: 1797 FKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQG---PDETMDGVPGENEHK 1853

Query: 3601 LLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELS 3780
              +                        H  S + E     N  ++K+
Sbjct: 1854 KKEEG----------------------HSKSQKPESTSSYNYRVVKE------------- 1878

Query: 3781 DKAPLIAYPLIRQMLVRLTGMCYRKGDP--KPDTMNQQLLKNMRVYEVVLEFISVPHDKK 3954
                         +L+RL+ +C ++     K     Q+LL+NM  + VVLE + +P++K
Sbjct: 1879 -------------ILLRLSKLCVQESASVRKSRKQQQRLLRNMGAHAVVLELLQIPYEKS 1925

Query: 3955 HDHD-----------------------------MMKLITLSHEFLRSFCKTNKENQSRLY 4047
             + D                             M +++ L+HEFL++FC  N++NQ+ L+
Sbjct: 1926 WNWDSSSAHLQVNLQILCNSIVFVMQSQAEDTRMQEIMKLAHEFLQNFCAGNQQNQALLH 1985

Query: 4048 KFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIF 4227
            K I+        +     I E  T+  IF NN +L S + E ++ H V  IE + RN  +
Sbjct: 1986 KHIN--------LFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQY 2037

Query: 4228 LELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRS 4407
            ++ LQ +V    K I+  Q+ + N    A ++V   Y D ASF+ L  MM+ E++
Sbjct: 2038 IKFLQTIVKAEGKFIKKCQDMLVN----AGEDVLVFYNDRASFQTLVQMMRSERD----R 2089

Query: 4408 SDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQ 4587
             D    L YHI LV LLA+CT GKN  TE+KC S +P+D IVRVVT + C+ EVK  Y+
Sbjct: 2090 MDENSPLMYHIHLVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYIN 2149

Query: 4588 LLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDI-RSLRVEKLTGAETATLEHYICHTVTE 4764
             L HCY+DT+ EMK+ Y + ++  +  N L DI R+           + LE Y+   V
Sbjct: 2150 FLNHCYVDTEVEMKEIYTSNHMWKLFENFLVDICRACNNTSDRKHADSILEKYVTEIVMS 2209

Query: 4765 VLIKFFEAPY---SALQQAKVDVHHHKKTFSEVLLELTYLEKGKLRGSKSSRNWY----- 4920
            ++  FF +P+   S   Q ++ +   K+T   V ++L    +G  R      NW
Sbjct: 2210 IVTTFFSSPFSDQSTTLQTQI-LTRIKETRQPVFVQLL---QGVFRVYHC--NWLMPSQK 2263

Query: 4921 -RVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQN 5097
              V  CI+ L+  A+   I +P  L     +         Q+ A +  W    +   R++
Sbjct: 2264 ASVESCIRVLSDVAKSRAIAIPVDLDSQVNNLFLKSHNIVQKTAMN--WRMTARNAARRD 2321

Query: 5098 TLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLF 5277
            ++    R Y            N++     ++   +  L PL  AE SVLV+VLH PELLF
Sbjct: 2322 SVLAASRDY-----------RNIIERLQDIVSALEDRLRPLVQAELSVLVDVLHRPELLF 2370

Query: 5278 PEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKM 5412
            PE +  R +C  GG + KLI+H K L++  ++ LC +VLQTL +M
Sbjct: 2371 PENTDARRKCESGGFICKLIKHTKQLLEENEEKLCIKVLQTLREM 2415



 Score =  449 bits (1154), Expect = e-124
 Identities = 298/836 (35%), Positives = 442/836 (52%), Gaps = 33/836 (3%)
 Frame = +1

Query: 5620 ERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMK 5799
            E  L  +QC L+  GAS+LV D+I+   S  +F ++I LA ALL  GN  +QHSF+ R+
Sbjct: 2636 EMSLADVQCHLDKEGASNLVIDLIMNATSDRVFHESILLAIALLEGGNTTIQHSFFCRLT 2695

Query: 5800 QKDIHEPFFKAILTRIQTAQNRLKSDM-MSCSD--SKPKVSST---------VLTPLIDA 5943
            +    E FFK    R++ AQ  +K+ + ++ SD  +K K   +         V  P+
Sbjct: 2696 EDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDEDSDRDVPNRKRVREPMTQI 2755

Query: 5944 GDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQ-DEEKSTDALPPEVALVE 6120
             +      L E     R    +   +  +D  +S  + A    D+ K    +   +++++
Sbjct: 2756 TEE-VRDQLLEASAATRKAYSTYRREADSDDHYSAAEGAQSAADKSKDDLEMSAVISIMQ 2814

Query: 6121 PILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFG-EIGE 6297
            PILR LQLLCENHN  LQNFLR Q+++TN+NLV ETL FLD +CGST G LG+ G  I E
Sbjct: 2815 PILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINE 2874

Query: 6298 HNFSLITQTLATLTEFCQGPCHENQNTMAMQE-NGLNIIISLVLNEIKPLADDHMELALE 6474
             N +LI QTL +LTE+CQGPCHENQN +A  E NG++II +L+LN              +
Sbjct: 2875 KNVALINQTLESLTEYCQGPCHENQNCIATHESNGIDIITALILN--------------D 2920

Query: 6475 IKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSI 6654
            I     K +  ++E           L+N A+     K L+  ++  ++  N+   +
Sbjct: 2921 INPLGKKRMDLVLE-----------LKNNAS-----KLLLAIMESRHDSENAERILYNMR 2964

Query: 6655 SRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIP 6834
             ++L      ++ KK+  Q  V                            +D  N +D+
Sbjct: 2965 PKELV-----EVIKKAYLQGEVE--------------------------FEDGENGEDL- 2992

Query: 6835 SVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRD 7014
            +  PR VGHNIYILAHQLA H+ EL+  L    + + D   EAL +Y + TAQIEIVR D
Sbjct: 2993 AASPRNVGHNIYILAHQLARHNKELQNMLKPGGQIEGD---EALEFYAKHTAQIEIVRSD 3049

Query: 7015 RTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQD 7194
            RT+E++VFP+ +IC +LTK++K  +Y  TERD QGSK+ +FF + E +++EM WQ+KL+
Sbjct: 3050 RTMEQIVFPVPNICEFLTKESKLRIYYTTERDEQGSKINDFFMKSEDLFNEMNWQKKLRA 3109

Query: 7195 RKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSIS---LGNLYSWFAVFSS 7365
            + +L WCA  +  W+ +SF+ A ++N LVA +YP       ++     G L++   +  +
Sbjct: 3110 QPFLYWCARNMSFWSSISFNLAVLMNLLVAFFYPFKGIRGGTLEPHLSGLLWTAMLISLA 3169

Query: 7366 FLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVAFVSN 7545
             ++A    H                       +G+  TL++ G   + NKI+ +++FV N
Sbjct: 3170 IVIALPKPHG-------IRALIASTILRLIFSVGLQPTLFLLGAFNVCNKIIFLMSFVGN 3222

Query: 7546 KGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVT 7725
             G   R    ++      Y L+YL IC LGL VH   Y +LLFD+++ EETL NVI SVT
Sbjct: 3223 CGTFTRGYKAMIMDVEFLYHLLYLLICALGLFVHEFFYSLLLFDLVYREETLLNVIKSVT 3282

Query: 7726 RNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDS---------SATISSGI 7878
            RN +SI+ T +LALIL+Y FSI+G+L+F+ DF LEVD + N++                +
Sbjct: 3283 RNGRSIILTAVLALILVYLFSIVGYLFFKDDFILEVDKLPNETLLPDRTEPGETMTGEFL 3342

Query: 7879 PSETC---PSEGCPGLQPS---XXXXXXXXXXXXSCETLWMCILQTGYQGLRNGGG 8028
             S+ C    SE C  + PS               +CETL MCI+     GLR+GGG
Sbjct: 3343 YSDVCKAGSSENCSSIIPSDQLIAEEMEEENKEHTCETLLMCIVTVLSHGLRSGGG 3398



 Score = 68.2 bits (165), Expect = 3e-09
 Identities = 36/76 (47%), Positives = 47/76 (61%)
 Frame = +1

Query: 109 LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
           LHIGDI SLY E S+N    GF+STLGLVDDRC+V+ + G   +PPKKFR+        +
Sbjct: 324 LHIGDICSLYAEGSTN----GFISTLGLVDDRCVVQPEAGDLNNPPKKFREANAMQRRAD 379

Query: 289 RYAAQKHLWTEQKRFQ 336
              A K  W  ++ F+
Sbjct: 380 AKGADKMQWKIKRNFK 395


>gi|47229530|emb|CAG06726.1| unnamed protein product [Tetraodon
            nigroviridis]
          Length = 2336

 Score =  916 bits (2368), Expect = 0.0
 Identities = 646/1872 (34%), Positives = 963/1872 (50%), Gaps = 131/1872 (6%)
 Frame = +1

Query: 1393 LHQSSDKWVHATNATE---KQNLHYSSKNEKGWVKVICEKNRVDKETFALLPVNPDEVRD 1563
            LH S+ + V      E     + H  SK  +GW   +C             PV+P EVRD
Sbjct: 134  LHASTHQLVDNPGCNEGLSATDRHLCSKRGQGWPLPLC-------------PVSPAEVRD 180

Query: 1564 LDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFS 1743
            LDFANDA K L +    ++ G +   E   + T+LL D + FV +  +   D L+I
Sbjct: 181  LDFANDASKVLASIAGKLEKGTITQNER-RAVTKLLEDLVFFVVDIPNSGQDVLEIMVNK 239

Query: 1744 PSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIFKTMFQLC 1923
            P+R+RQKL+REQ +L Q+F LL+APF     T              D R+  F+ + +LC
Sbjct: 240  PNRERQKLMREQNILKQIFKLLQAPF-----TDSGDGPMLRLEELADQRHAPFRHICRLC 294

Query: 1924 YCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVE 2103
            Y +L++SQ  YRKNQE++A++F  +Q+QIG+D++AEDT+TA+LHNN KLLEK++    ++
Sbjct: 295  YRVLRHSQQDYRKNQEYIAKQFRFMQKQIGYDVLAEDTITALLHNNRKLLEKHITAAEID 354

Query: 2104 RFVELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKIIDGEIE 2283
             FV LVR NR+ +FLDYL+DLCV   ++    QELIC +VL   + DI ++TK++    E
Sbjct: 355  TFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICNAVLDPANADILIETKLVLSRFE 414

Query: 2284 VGWAP---------------------------NFRKLVDIAEGAKSNS-DDAEHLDYYRH 2379
            +  AP                             + + ++A+ AK    +D E + YYR+
Sbjct: 415  IEGAPLGENSLESEEDEEEVWLFWKDNNNKEIRSKSIRELAQDAKEGQKEDQEVISYYRY 474

Query: 2380 QLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLH 2559
            QL+L ++MC ++QYLAI+         IS QL  +L+L+CMSD  LP+DLR SF R+MLH
Sbjct: 475  QLNLFARMCLDRQYLAIN--------KISGQLDVDLILRCMSDEDLPFDLRASFCRMMLH 526

Query: 2560 LHVVRG--SPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDG-SRMRIGEGIAHKVLAT 2730
            +HV R     ++ +++ARLW  IP  + +  Y++       DG S+  I E  + + +
Sbjct: 527  MHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDN-------DGTSKDEIKERFS-QTMEF 578

Query: 2731 VETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIIN-- 2904
            VE YL  +  QS         +KLT+E+VNLA+ L  F FY+F+DLL+LT+ LLAI++
Sbjct: 579  VENYLRDVVCQSFPFADK-EKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCV 637

Query: 2905 ------------EGPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEA 3048
                        +   ++     R++      MS+ ++RGG          T   T +
Sbjct: 638  HIGTAFGFNKLDKDDESKGSNVMRSIHGVGELMSQVVLRGGGFLPMTPSISTSRDTVKTQ 697

Query: 3049 GRTKEGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMH------ 3210
               ++   L + TKL + EILQF+++VR DYRI+  LS FK  F  DE  S
Sbjct: 698  TEPEKQDILVMDTKLKIIEILQFILNVRLDYRISCLLSIFKREF--DESNSQSELPVGGA 755

Query: 3211 -------SASINERMASELYDAIYRSSGHE--LHLDGRDGQLLLAILLQMTMSDYPPLTS 3363
                     +++     E  + I+  S     L LD   G+  L +LL +TM DYPPL S
Sbjct: 756  VEGPNNMPGALDFEHIEEQAEGIFGGSEENTPLDLDDHGGRTFLRVLLHLTMHDYPPLVS 815

Query: 3364 IALKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDR 3543
             AL + FRHF+Q QE+L+  KQVQLLV++ DVENY+QI  DL  L+++ EKSELWV+
Sbjct: 816  RALHLLFRHFSQRQEVLQAFKQVQLLVTSQDVENYKQIKSDLDQLRSIVEKSELWVY--- 872

Query: 3544 HHSIDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLN 3723
                       K + +E  +           D+G+ +                 C +  +
Sbjct: 873  -----------KRQGSEEGM-----------DTGEGL-----------------CAEPEH 893

Query: 3724 RLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKG--DPKPDTMNQQLLK 3897
            +L+   + + ++    +  +      Y +++++L+RL+ +C ++G    K     Q+LL+
Sbjct: 894  KLVPYFENSLSSKYKTKKPESTSSYNYRVVKEILLRLSKLCVQEGLSGRKSKKQQQRLLR 953

Query: 3898 NMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAK 4077
            NM  + VVLE + +P++K  D  M  ++ L+H+FL++FC  N++NQ+ L+K I+   +
Sbjct: 954  NMGAHSVVLELLQIPYEKGEDLRMQDIMKLAHQFLQNFCAGNQQNQALLHKHINLFLNP- 1012

Query: 4078 EGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCV 4257
             G+L   T++       IF NN +L S + E ++ H V  IE + RN  +L+ LQ +V
Sbjct: 1013 -GILEAITMQH------IFMNNFQLCSEINERVVQHFVHCIETHGRNVQYLKFLQTIVKA 1065

Query: 4258 YDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYH 4437
             +K I+  Q+ V  E+  A ++V   Y D ASF+ L  MM+ E++      D    L YH
Sbjct: 1066 ENKFIKKCQDIVMAELVNAGEDVLVFYNDRASFQTLVQMMRSERDRM----DENSPLMYH 1121

Query: 4438 IELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTD 4617
            I LV LLA+CT GKN  TE+KC S +P+D IVRVVT + C+ EVK  Y+  L HCY+DT+
Sbjct: 1122 IHLVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCYVDTE 1181

Query: 4618 AEMKDAYKTEYVDHILNNLLEDIRSLRVEKLTG----AETATLEHYICHTVTEVLIKFFE 4785
             EMK+ Y + ++  +  N L DI   RV   T     A+T  LE Y+  TV  ++  FF
Sbjct: 1182 VEMKEIYTSNHMWKLFENFLVDI--CRVCNSTSDRKHADTI-LERYVTETVMSIVTTFFS 1238

Query: 4786 APYSALQQAKVDVHHHKKTFSEVLLEL--TYLEKGKLRGSKSSRNWYRVAECIKRLTKWA 4959
            +P+S        +   +  F ++L  +   Y     +   K S     V  CIK L+  A
Sbjct: 1239 SPFS---DQSTSLQTRQPVFVQLLQAVFRVYHCNWLIPVQKGS-----VENCIKVLSDVA 1290

Query: 4960 EEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGHRLYGTSNS 5139
            +   I +P  L     +         Q+ A S  W    +   R++++    R Y
Sbjct: 1291 KGRAIAIPVDLDNQVHNLFVKSNNIVQKTAMS--WRLSARNAARRDSVVTASRDY----- 1343

Query: 5140 MTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCARGG 5319
                   N++     ++   +  L PL  AE SVLV+VLH PELLFPE +  R +C  GG
Sbjct: 1344 ------RNIIERLQDIVSALEDRLRPLVQAELSVLVDVLHRPELLFPENTDSRKKCESGG 1397

Query: 5320 VVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKQQLTHQGHRVYNSSVE-------- 5475
             + KLI+H K L++  ++ LC +VLQTL +M   TK +   +  R ++  ++
Sbjct: 1398 FICKLIKHTKQLLEENEERLCIKVLQTLREMM--TKDRGYGEKFRAFDDEMDMPKQNKMG 1455

Query: 5476 -KGXXXXXXXXXXYFGHHNNHHPPLDRQQSXXXXXXXXXXXXXXXTWSQ----------E 5622
             KG          Y+G   N H    R+ S                 S           E
Sbjct: 1456 FKGEALRQILVNRYYG---NFHRSGGRRDSLTFANSPLSPIGPGRNQSGLGVPGGLSRGE 1512

Query: 5623 RDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQ 5802
              L  +QC L+  GASDLV D+I+   S  +F ++I LA ALL  GN  +Q SF+ R+ +
Sbjct: 1513 MSLAEVQCHLDKEGASDLVIDLIMNTTSDRVFQESILLAIALLEGGNTTIQRSFFCRLTE 1572

Query: 5803 KDIHEPFFKAILTRIQTAQNRLKSDM-MSCSD------------------SKPKVSSTVL 5925
                E FF+    R++ AQ  +K+ + ++ SD                   K + SS V+
Sbjct: 1573 DKKSEKFFRVFYDRMKLAQLEIKATVTVNTSDLGNRKRVDDSQDKDGPVRKKVRESSVVM 1632

Query: 5926 TPLIDAGDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDA-LPP 6102
            T  +          L E     +    S   +   +   ++ D      ++   D  +
Sbjct: 1633 TEDV-------REQLLEASSATKKAFNSYRREADPEDHFNVADGQSNTGDKNQDDGEMSF 1685

Query: 6103 EVALVEPILRVLQLLCENHNSLLQN-------------FLRKQSDRTNHNLVSETLSFLD 6243
             + +++PILR LQLLCENHN  LQN             FLR Q+++ N+NLV ETL FLD
Sbjct: 1686 VIVIMQPILRFLQLLCENHNRDLQNLYRIYIFFVPHQNFLRCQNNKNNYNLVCETLQFLD 1745

Query: 6244 TVCGSTKGSLGVFG-EIGEHNFSLITQTLATLTEFCQGPCHENQ------NTMAMQE-NG 6399
             +CGST G LG+ G  I E N +LI QTL +LTE+CQGPCHENQ      N +A  E NG
Sbjct: 1746 CICGSTTGGLGLLGLYINEKNVALINQTLESLTEYCQGPCHENQFVYILQNCIATHESNG 1805

Query: 6400 LNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGG 6579
            ++III+L+LN+I PL    M+L LE+K+ ASKLLLAIMESRHD ENA R+L NM
Sbjct: 1806 IDIIIALILNDINPLGKKRMDLVLELKNNASKLLLAIMESRHDSENAERILYNMR----- 1860

Query: 6580 PKQLVHAIKQAY 6615
            PK+LV  IK+AY
Sbjct: 1861 PKELVEVIKKAY 1872



 Score =  164 bits (414), Expect = 5e-38
 Identities = 99/296 (33%), Positives = 153/296 (51%), Gaps = 12/296 (4%)
 Frame = +1

Query: 7183 KLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSISLG-NLYSWFAVF 7359
            +L+ +  L WC+  + +W+ + F+ A ++N LV  +YPL       +    +   W  VF
Sbjct: 1915 QLEAQPVLYWCSRNMSVWSNICFNLALLMNLLVCLFYPLEGVQGVMLDPHLSAMLWMGVF 1974

Query: 7360 SSFLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVAFV 7539
            ++ ++   +         +               +G+  TL++ G   + NKI+ +++FV
Sbjct: 1975 AALVIVLVMPQQL-----SVRALVIITILRLIFSVGLEPTLFLLGAFNVCNKIIFLISFV 2029

Query: 7540 SNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIAS 7719
             N+G   R    ++      Y L+YL IC LG+ VH   Y +LLFD+++ EETL NVI S
Sbjct: 2030 GNRGTFTRGYKAMVLDFEFLYHLIYLIICCLGVFVHVFFYSLLLFDLVYREETLLNVIKS 2089

Query: 7720 VTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSG--IPSETC 7893
            VTRN +SIV T +LALIL+Y FSI+G+++F+ DF LEVD V N   ATI  G  + S
Sbjct: 2090 VTRNGRSIVLTAVLALILVYLFSIVGYIFFKDDFILEVDRVPN---ATIKGGGSLASVFV 2146

Query: 7894 PSEGCPG---------LQPSXXXXXXXXXXXXSCETLWMCILQTGYQGLRNGGGIG 8034
            P+  C G          Q              +C++L MCI+     GLR+GGG+G
Sbjct: 2147 PTGMCQGGIDQNCTAKAQLEEDNKDKDDDVERTCDSLLMCIVTVLSHGLRSGGGVG 2202



 Score =  127 bits (319), Expect = 5e-27
 Identities = 52/104 (50%), Positives = 82/104 (78%)
 Frame = +1

Query: 8227 GLDRSRFDNRSVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDW 8406
            GL+R +FDN++VTFE H + EHN+WHYL++IV++++KD TE+TGPESYVA+ +K+ NLDW
Sbjct: 2202 GLERDKFDNKTVTFEEHIKEEHNMWHYLFFIVLVKVKDSTEYTGPESYVAEMIKEHNLDW 2261

Query: 8407 FPRMQALSLQDSELDTDQSEVKQMKDQLLQMMTLMREIISQNEE 8538
            FPRM+A+SL  S+ + +Q+E++ ++++L   M L+  +  Q  E
Sbjct: 2262 FPRMRAMSLVSSDAEGEQNEIRNLQEKLESTMRLVANLSGQLSE 2305



 Score = 63.9 bits (154), Expect = 6e-08
 Identities = 32/50 (64%), Positives = 37/50 (74%)
 Frame = +1

Query: 109 LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFR 258
           LHIGDI SLY E S+N    GF+STLGLVDDRC+V+   G   +PPKKFR
Sbjct: 9   LHIGDICSLYAEGSTN----GFISTLGLVDDRCVVQPDAGDLNNPPKKFR 54


>gi|19388011|gb|AAH25805.1| Itpr5 protein [Mus musculus]
          Length = 1412

 Score =  837 bits (2161), Expect = 0.0
 Identities = 533/1497 (35%), Positives = 791/1497 (52%), Gaps = 33/1497 (2%)
 Frame = +1

Query: 4168 EELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDN 4347
            E ++ H V  IE + R+  +L  LQ +V    K ++  Q+ V  E+    ++V   Y D
Sbjct: 1    ERVVQHFVHCIETHGRHVEYLRFLQTIVKADGKYVKKCQDMVMTELINGGEDVLIFYNDR 60

Query: 4348 ASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDH 4527
            ASF  L  MM  E+       D    L YHI LV LLA CT GKN  TE+KC S +P+D
Sbjct: 61   ASFPILLNMMCSERAR----GDESGPLAYHITLVELLAACTEGKNVYTEIKCNSLLPLDD 116

Query: 4528 IVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEK 4707
            IVRVVT   C+ EVK  Y+  + HCY+DT+ EMK+ Y + ++  +  N L D+  +
Sbjct: 117  IVRVVTHDDCIPEVKIAYVNFVNHCYVDTEVEMKEIYTSNHIWKLFENFLVDMARVCNTT 176

Query: 4708 LTGAETAT-LEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKG 4884
                   T LE  +  +V  ++  FF +P+S        +  H+  F ++L     +
Sbjct: 177  TDRKHADTFLERCVTESVMNIVSGFFNSPFS---DNSTSLQTHQPVFIQLLQSAFRIYNC 233

Query: 4885 KLRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKW 5064
                     +   V  CI+ L + A+   I +P  L     S   ++  K    +S+ +
Sbjct: 234  TWPNPAQKAS---VESCIRALAEVAKNRGIAIPVDLD----SQVNTLFMK--NHSSTVQR 284

Query: 5065 IGIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVL 5244
              +G RL+ ++       L G +         N++     ++   +    P+  AE SVL
Sbjct: 285  AAMGWRLSARSGPRFKEALGGPAWDYR-----NIIEKLQDVVASLEQQFSPMMQAEFSVL 339

Query: 5245 VEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCT 5424
            V+VL++PELLFPEGS  R +C  G  ++KLI H K LM+ K++ LC ++LQTL +M +
Sbjct: 340  VDVLYSPELLFPEGSDARIRC--GAFMSKLINHTKKLME-KEEKLCIKILQTLREMLEKK 396

Query: 5425 KQQLTHQGHRVYNSSVEKGXXXXXXXXXXYFGHHNNHHPPLDRQQSXXXXXXXXXXXXXX 5604
                        +S +E+G          YF    +H   ++   S
Sbjct: 397  ------------DSFMEEGSTLRRILLNRYF--KGDHSVSVNGPLSGAYAKTAQVGGGFS 442

Query: 5605 XTWSQERDLYA--IQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQH 5778
               S +  +    IQC L+  GAS+LV D+I+   +  IF + I L  ALL  GN + Q+
Sbjct: 443  GQDSDKTGISMSDIQCLLDKEGASELVIDVIVNTKNDRIFSEGILLGIALLEGGNTQTQY 502

Query: 5779 SFYMRMKQKDIHEPFFKAILTRIQTAQNRLKSDM----MSCSDSKPKVSSTVLT--PLID 5940
            SFY ++ ++   E FFK +  R++ AQ  ++S +    +     K +  S V+   P +
Sbjct: 503  SFYQQLHEQKKSEKFFKVLYDRMKAAQKEIRSTVTVNTIDLGSKKREEDSDVMALGPRMR 562

Query: 5941 AGDT------GFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTD--AL 6096
              D+      G  G L E              ++  ++    P       EEKS +   +
Sbjct: 563  VRDSSLHLREGMKGQLTEASSATSKAYCVYRREMDPEIDTMCPGQEAGSAEEKSAEEVTM 622

Query: 6097 PPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLG 6276
             P + ++ PILR LQLLCENHN  LQNFLR Q+++TN+NLV ETL FLD +CGST G LG
Sbjct: 623  SPAITIMRPILRFLQLLCENHNRELQNFLRNQNNKTNYNLVCETLQFLDCICGSTTGGLG 682

Query: 6277 VFG-EIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQE-NGLNIIISLVLNEIKPLAD 6450
            + G  I E N +L+ QTL +LTE+CQGPCHENQ  +A  E NG++III+L+LN+I PL
Sbjct: 683  LLGLYINERNVALVNQTLESLTEYCQGPCHENQTCIATHESNGIDIIIALILNDINPLGK 742

Query: 6451 DHMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNS 6630
              M+L L++K+ AS                              K L+  ++  ++  N+
Sbjct: 743  YRMDLVLQLKNNAS------------------------------KLLLAIMESRHDSENA 772

Query: 6631 NHHMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDD 6810
               +     R+L      D+ K +  Q                G+   H         D+
Sbjct: 773  ERILFNMRPRELV-----DVMKNAYNQ----------------GLECDHG--------DE 803

Query: 6811 KFNDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLD-GSDEKKDDLTREALNYYKERT 6987
            +  DD    V P++VGHNIYILAHQLA H+  L+  L  GSD ++ D   EAL YY   T
Sbjct: 804  EGGDD---GVSPKDVGHNIYILAHQLARHNKLLQQMLKPGSDPEEGD---EALKYYANHT 857

Query: 6988 AQIEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHE 7167
            AQIEIVR DRT+E++VFP+ +IC +LT+++K  V+N TERD QGSKV +FF + E +Y+E
Sbjct: 858  AQIEIVRHDRTMEQIVFPVPNICEFLTRESKYRVFNTTERDEQGSKVNDFFQQTEDLYNE 917

Query: 7168 MIWQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYS- 7344
            M WQ+K+++   L W    + LW  +SF+ A  +N  VA +YP  +  +   +L  ++S
Sbjct: 918  MKWQKKIRNNPALFWFPRHISLWGSISFNLAVFINLAVALFYPFGDDGDEG-TLSPMFSA 976

Query: 7345 --WFAV-FSSFLLAHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNK 7515
              W AV   + +L  + +   I                    IG+  TL + G   L NK
Sbjct: 977  LLWVAVAICTSMLFFFSKPVGI------RPFLVSVMLRSIYTIGLGPTLILLGAANLCNK 1030

Query: 7516 IVHVVAFVSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEE 7695
            IV +V+FV N+G   R    ++      Y + Y+ +C+LGL VH   Y  LLFD+++ EE
Sbjct: 1031 IVFLVSFVGNRGTFTRGYRAVILDMAFLYHVAYVLVCMLGLFVHEFFYSFLLFDLVYREE 1090

Query: 7696 TLQNVIASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSG 7875
            TL NVI SVTRN +SI+ T +LALIL+Y FSI+GFL+ + DF +EVD ++N +  T + G
Sbjct: 1091 TLLNVIKSVTRNGRSIILTAVLALILVYLFSIIGFLFLKDDFTMEVDRLKNRTPVTGNHG 1150

Query: 7876 IPS-------ETCPSEGCPGLQPSXXXXXXXXXXXX--SCETLWMCILQTGYQGLRNGGG 8028
            +P+       ETC  E C    PS              +C+TL MCI+    QGLRNGGG
Sbjct: 1151 VPTMTLSSMMETCQKENCSPTIPSSNTAGEEGEDGIERTCDTLLMCIVTVLNQGLRNGGG 1210

Query: 8029 IGDVLRNPAPWEDMFIWRVAYDMTXXXXXXXXXXXXXXXXXXDTFGDLRAEKNEKEQILK 8208
            +GDVLR P+  E +F  RV YD+                   DTF DLR+EK +KE+ILK
Sbjct: 1211 VGDVLRRPSKDEPLFAARVVYDLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILK 1270

Query: 8209 NNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVK 8388
              CFICGL+R +FDN++V+FE H ++EHN+WHYLY+IV++++KD TE+TGPESYVAQ +
Sbjct: 1271 TTCFICGLERDKFDNKTVSFEEHIKSEHNMWHYLYFIVLVKVKDPTEYTGPESYVAQMIT 1330

Query: 8389 DRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLLQMMTLMREIISQNEESRAFMEQ 8559
            ++NLDWFPRM+A+SL  +E D++Q+E++ ++++L   M+L++++  Q  E +  M +
Sbjct: 1331 EKNLDWFPRMRAMSLVSNEGDSEQNEIRNLQEKLESTMSLVKQLSGQLAELKEQMTE 1387


>gi|47227347|emb|CAF96896.1| unnamed protein product [Tetraodon
            nigroviridis]
          Length = 2743

 Score =  744 bits (1920), Expect = 0.0
 Identities = 486/1241 (39%), Positives = 684/1241 (54%), Gaps = 99/1241 (7%)
 Frame = +1

Query: 109  LHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVN 288
            LHIGDI SLY E ++     GF+STLGLVDDRC+V+   G   +PPKKFRDCLF++CP+N
Sbjct: 9    LHIGDICSLYAEGTTC----GFISTLGLVDDRCVVQPDTGDLNNPPKKFRDCLFRLCPMN 64

Query: 289  RYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQ 468
            RY+AQK  W   K    G+S  D  L+NKL  AAD E+++NESE +K LG VIQYG+++Q
Sbjct: 65   RYSAQKQFWKAAK--PGGNSTTDAVLLNKLHHAADLEKKQNESENRKLLGTVIQYGNVIQ 122

Query: 469  LLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKI 648
            LLH+KSNKY+TV K  PA  E+NAM+V LD AGNEGSWF I+P YK  ++GD+V  G+K+
Sbjct: 123  LLHLKSNKYLTVNKRLPALLEKNAMRVTLDSAGNEGSWFYIQPFYKLRSLGDSVVIGDKV 182

Query: 649  SLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSV 828
             L P       AG     LH SS  L+D+    EVN +N  T W+V +F+ + +N++  +
Sbjct: 183  VLNP-----VNAG---QPLHASSHQLVDNPGCNEVNSVNCNTSWKVVLFMKWSDNKETIL 234

Query: 829  KSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTN 1008
            K GDVVRLFHA+Q+ FLT D   K+      VFLR T R SA  ATSS+ALWEV+VV  +
Sbjct: 235  KGGDVVRLFHAEQEKFLTCDDHRKK----QYVFLRTTGRQSATSATSSKALWEVEVVHHD 290

Query: 1009 AYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRPPLLSALSQKSRPMLERTNN 1188
              RGG   WN  +RFKHLAT  YL+AE  +V
Sbjct: 291  PCRGGAGYWNSLFRFKHLATGCYLAAEVGEVV-------------------------DFT 325

Query: 1189 PMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEV 1368
            P     D  N          Q+ +  ++ L P        D + +F+LDP+T    +  V
Sbjct: 326  PFNFQLDADNEALRGRLRAPQEKV--MYTLVPVPDGM---DISSIFELDPTTLRGGDSMV 380

Query: 1369 PRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWVKVI-CEKNRVDKETFALLPVN 1545
            PR SYVRL H  ++ WVH+T       L    + EK  + +I     + DKE FA++PV
Sbjct: 381  PRNSYVRLRHLCTNTWVHST------VLPIDKEEEKPVMLMIGTSAVKEDKEAFAIVPVP 434

Query: 1546 PDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADPL 1725
            P EVRDLDFANDA K L +    ++ G +   E     T+LL D + FV +  +   D L
Sbjct: 435  PAEVRDLDFANDASKVLASIAGKLEKGTITQNER-RFVTKLLEDLVFFVVDIPNSGQDVL 493

Query: 1726 KISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXXXXXDSRNEIFK 1905
            +I    PSR+RQKL+REQ +L Q+F LL+APF     T              D R+  F+
Sbjct: 494  EIMVNKPSRERQKLMREQNILKQIFKLLQAPF-----TDSGDGPMLRLEELGDQRHAPFR 548

Query: 1906 TMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYV 2085
             + +LCY +L++SQ  YRKNQ   A++F  +Q+QIG+D++AEDT+TA+LHNN KLLEK++
Sbjct: 549  HICRLCYRVLRHSQQDYRKNQ--AAKQFRFMQKQIGYDVLAEDTITALLHNNRKLLEKHI 606

Query: 2086 KTPHVERFVELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKI 2265
                ++ FV LVR NR+ +FLDYL+DLCV   ++    QELIC +VL   + DI ++TK+
Sbjct: 607  TAAEIDTFVTLVRKNREPRFLDYLSDLCVSMQKSIPVTQELICNAVLDPSNADILIETKL 666

Query: 2266 IDGEIEVGWAPN-------------------------FRKLVDIAEGAK-SNSDDAEHLD 2367
            +    E+  A N                          + + ++A+ AK    +D E +
Sbjct: 667  VLSRFEIETASNGESPVEAEDEEEVWLFWKDNCKEIRSKSIRELAQDAKEGQKEDLEVVS 726

Query: 2368 YYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTR 2547
            YYR QL+L ++MC ++QYLAI+         IS QL  +L+L+CMSD  LP+DLR SF R
Sbjct: 727  YYRCQLNLFARMCLDRQYLAIN--------KISGQLDVDLILRCMSDEDLPFDLRASFCR 778

Query: 2548 LMLHLHVVRG--SPMSAIRHARLWWSIPENVNV-STYESVSVEAYSDG-SRMRIGEGIAH 2715
            LMLH+HV R     ++ +++ARLW  IP  + +  +Y+       +DG +R  I E  +
Sbjct: 779  LMLHMHVDRDPQEQVTPVKYARLWSEIPSKIAIDDSYD-------NDGTTRDEIKERFS- 830

Query: 2716 KVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLA 2895
              +  VETYL  + +Q++        +KLT+E+VNLA+ L  F FY+F+DLL+LT+ LL
Sbjct: 831  LTMDFVETYLREVVSQNVPFSDK-EKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKVLLN 889

Query: 2896 I-----------INEGPATEQVPSHRAM--VNAIRN-MSKSMMRGGNKENSKDLAKTPSV 3033
            I           IN+    E+      M  ++ +   M++ ++RGG    +    +
Sbjct: 890  ILDCVHVSTIYPINKMEKEEENKGSNVMKSIHGVGELMTQVVLRGGGLLPTTPTHQPQGD 949

Query: 3034 TAEEAGRTKEGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDE-----DG 3198
              +     +    + + TKL + EILQF+++VR DYRI+  L  FK+ F  DE     DG
Sbjct: 950  VVKTQTEPEREDIMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKHEF--DESNPQADG 1007

Query: 3199 S-----------------------------------------------LMHSASINERMA 3237
            +                                               L+   +++
Sbjct: 1008 AAAQNGTNNVTSQMPGTMDRFDSRQSFNTVGEAMLIRCNFLLNLKKTLLISVGNLDFEKI 1067

Query: 3238 SELYDAIYRSSGHELHLDGRD--GQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQEL 3411
             E  + I+  S     LD  D  G+  L +LL +TM DYPPL S AL + FRHF+Q QE+
Sbjct: 1068 EEQAEGIFGGSEENSPLDLDDHGGRTFLRVLLHLTMHDYPPLVSGALHLLFRHFSQRQEV 1127

Query: 3412 LEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVH 3534
            L   KQVQLLV++ DV+NY+QI  DL  L+++ EKSELWV+
Sbjct: 1128 LMAFKQVQLLVTSQDVDNYKQIKSDLDQLRSIVEKSELWVY 1168



 Score =  706 bits (1822), Expect = 0.0
 Identities = 480/1340 (35%), Positives = 698/1340 (51%), Gaps = 43/1340 (3%)
 Frame = +1

Query: 3958 DHDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFR 4137
            D  M  ++ L+HEFL++FC  N++NQ  L+K ++   +   G+L   T++       IF
Sbjct: 1214 DIRMQDIMKLAHEFLQNFCAGNQQNQVLLHKHVNLFLNP--GILEATTMQH------IFM 1265

Query: 4138 NNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAAS 4317
            NN +L S + E ++ H V   E + R+  +L+ LQ +V   +K I+  Q+ V  E+  +
Sbjct: 1266 NNFQLCSEINERVVQHFVHCTETHGRHVQYLKFLQTIVKAENKSIKKCQDIVMAEMVNSG 1325

Query: 4318 DEVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTEL 4497
            ++V   Y D ASF+ L  MM+ E++      D    L YHI LV LLA+CT GKN  TE+
Sbjct: 1326 EDVLVFYNDRASFQTLIQMMRSERDRM----DENSPLLYHIHLVELLAVCTEGKNVYTEI 1381

Query: 4498 KCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLL 4677
            KC S +P+D IVRVVT + C+ EVK  Y+  L HCY+DT+ EMK+ Y + ++  +  N L
Sbjct: 1382 KCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCYVDTEVEMKEIYTSNHMWKLFENFL 1441

Query: 4678 EDIRSL--RVEKLTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSE 4851
             DI  +         A+T TLE Y+  TV  ++  FF +P+S       D     +T
Sbjct: 1442 VDICRVCNNTSDRKHADT-TLERYVTETVMSIVTCFFSSPFS-------DQSTSLQTRQP 1493

Query: 4852 VLLELTYLEKGKLRGSKSSRNWYR------VAECIKRLTKWAEEHNITLPATLAGPQMSG 5013
            V ++L    +G  R      NW        V  CIK L+  A+   I +P  L
Sbjct: 1494 VFVQLL---QGVFRVYHC--NWLNPVQKASVEACIKVLSDVAKSRAIAIPVDL------- 1541

Query: 5014 QTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIG 5193
             + V   + ++ +  +   +  RL+ +NT          S+  T     N++     ++
Sbjct: 1542 DSQVNNLFVKSNNVVQKSILSWRLSAKNTSRRD------SSLTTSKDYRNIIERLQDIVS 1595

Query: 5194 EFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQD 5373
              +  L PL  AE SVLV+VLH PELLFPE +  R +C  GG ++KLI+H K L++  ++
Sbjct: 1596 ALEDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKCESGGFISKLIKHTKQLLEENEE 1655

Query: 5374 NLCARVLQTLCKMCDCTKQQLTHQGHRVYNSSVEKGXXXXXXXXXXYFGHHNNHHPPLDR 5553
             LC +VLQTL +M   TK        R Y    EKG          Y+G+  ++     R
Sbjct: 1656 RLCIKVLQTLREMM--TKD-------RGYG---EKGEALRHILVNRYYGNVKSNQ----R 1699

Query: 5554 QQSXXXXXXXXXX----------XXXXXTWSQERDLYAIQCKLNDAGASDLVTDIIIMEP 5703
            ++S                             E  L  +QC L+  GASDLV D+I+
Sbjct: 1700 RESLATFSNGPVTPGVQGKVPAVVSSGIGGRGELSLAEVQCHLDKEGASDLVIDLIMNAT 1759

Query: 5704 SREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRLKSDM- 5880
            S  IF ++I LA ALL  GN  +Q SF+ R+   +  E FF+    R++ AQ  +K+ M
Sbjct: 1760 SDRIFQESILLAIALLEGGNPVIQRSFFHRLTGDNKSERFFRVFNDRMKLAQQEIKATMT 1819

Query: 5881 MSCSDSKPKVSSTVLTPLIDAGDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLA 6060
            ++ SD   K          +  D    G + +VP  V   +     QL+   T +    A
Sbjct: 1820 VNTSDLGSKKKDE------EPADKDAPGRVKDVPV-VAVVTEEAKEQLAEASTVTKKAFA 1872

Query: 6061 PYQDE------EKSTDALPPEVA--------------LVEPILRVLQLLCENHNSLLQNF 6180
             Y+ E      + + +  P   A              +++PILR+LQLLCENHN  LQNF
Sbjct: 1873 TYRREMEAEEHQAAAEGTPVPTADKGQEDGEMSVIITIMQPILRLLQLLCENHNRDLQNF 1932

Query: 6181 LRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFG-EIGEHNFSLITQTLATLTEFCQGP 6357
            LR Q+++ N+NLV ETL FLD +CGST G LG+ G  I E N  LI QT+ +LTE+CQGP
Sbjct: 1933 LRNQNNKNNYNLVCETLQFLDCICGSTTGGLGLLGLYINEKNVGLINQTVESLTEYCQGP 1992

Query: 6358 CHENQNTMAMQE-NGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIMESRHDGE 6534
            CHENQN +A  E NG++III+L+LN+I PL    M+L LE+K+ ASKLLLAIMESRHD E
Sbjct: 1993 CHENQNCIATHECNGIDIIIALILNDINPLGKKRMDLVLELKNNASKLLLAIMESRHDSE 2052

Query: 6535 NANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLKKKSGPQI 6714
             A R+L NM      PK+LV  IK+A                  + Q E ++++
Sbjct: 2053 TAERILYNMR-----PKELVEVIKKA------------------YMQGEIEVEE------ 2083

Query: 6715 TVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNIYILAHQLAI 6894
                   PE   +                       ++  S  PR VGHNIYILAHQLA
Sbjct: 2084 -------PEEGEEG----------------------EEEHSASPRNVGHNIYILAHQLAR 2114

Query: 6895 HDGELEIWLD-GSDEKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPINDICSYLTK 7071
            H+ EL+  L  G    + D   EAL +Y + TAQIEIVR DRT+E++VFP+ +IC +LT+
Sbjct: 2115 HNKELQAMLKPGGTYGEGD---EALEFYAKHTAQIEIVRLDRTMEQIVFPVPNICEFLTQ 2171

Query: 7072 DTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPLWTRLSF 7251
            ++K  VY  TERD QGSK+ +FF   E +++EM WQ+KL+ +  L WC+  +  W+ +SF
Sbjct: 2172 ESKLRVYYTTERDEQGSKINDFFLRSEDLFNEMNWQKKLRAQPILYWCSRNMSFWSSISF 2231

Query: 7252 HFAFIVNALVARYYPLPEHSNSSISLG-NLYSWFAVFSSFLLAHYLRHDKIYLHKTXXXX 7428
            + A ++N LVA +YPL      ++    +   W A+  S  +   L
Sbjct: 2232 NLAVLMNLLVAFFYPLEAVRGGTLEPHLSALLWMAMLVSLAIVIVLPQP-----HGIRAL 2286

Query: 7429 XXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRNLHYLL 7608
                       +G+  TL++ G   L NK++ +++FV N+G   R    ++      Y L
Sbjct: 2287 IASTILRLIFSVGLEPTLFLLGAFNLCNKVIFLMSFVGNRGTFTRGYKAMITDVEFLYHL 2346

Query: 7609 VYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALILLYFFS 7788
            +YL IC LG+ +H   Y +LLFD+++ EETL NVI SVTRN +SIV T +LALIL+Y FS
Sbjct: 2347 LYLIICCLGVFLHVFFYSLLLFDLVYREETLLNVIKSVTRNGRSIVLTAVLALILVYLFS 2406

Query: 7789 ILGFLYFRHDFYLEVDPVEN 7848
            I+G+++F+ DF L VD + N
Sbjct: 2407 IVGYIFFKDDFILAVDRIPN 2426



 Score =  206 bits (525), Expect = 6e-51
 Identities = 93/199 (46%), Positives = 138/199 (68%)
 Frame = +1

Query: 7963 SCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTXXXXXXXXXXXXXX 8142
            +C++L MCI+     GLR+GGG+GDVLR P+  E +F  RV YD+
Sbjct: 2520 TCDSLLMCIVTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVIYDLLFFFMVIIIVLNLIF 2579

Query: 8143 XXXXDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLYYIV 8322
                DTF DLR+EK +KE+ILK  CFICGL+R +FDN++VTFE H + EHN+WHYL++IV
Sbjct: 2580 GVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVTFEEHIKVEHNMWHYLFFIV 2639

Query: 8323 MLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLLQMM 8502
            ++++KD TE+TGPESYVA+ ++++NLDWFPRM+A+SL  S+ D +Q+E++ ++++L   M
Sbjct: 2640 LVKVKDSTEYTGPESYVAEMIREQNLDWFPRMRAMSLVSSDADGEQNEIRSLQEKLESTM 2699

Query: 8503 TLMREIISQNEESRAFMEQ 8559
             L+  +  Q  E +  M +
Sbjct: 2700 KLVSNLSGQLTELKEQMTE 2718



 Score = 49.7 bits (117), Expect = 0.001
 Identities = 63/301 (20%), Positives = 119/301 (38%), Gaps = 48/301 (15%)
 Frame = +1

Query: 3865 KPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLS---HEFLRSFCKT----- 4020
            KP    Q+L++   + + + + +  P     D  M++L  L    H   R  C+
Sbjct: 499  KPSRERQKLMREQNILKQIFKLLQAPFTDSGDGPMLRLEELGDQRHAPFRHICRLCYRVL 558

Query: 4021 -------NKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELAS-NVPEEL 4176
                    K   ++ ++F+  +K     +L  +TI       A+  NNR+L   ++
Sbjct: 559  RHSQQDYRKNQAAKQFRFM--QKQIGYDVLAEDTI------TALLHNNRKLLEKHITAAE 610

Query: 4177 IAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDE---------VR 4329
            I   V L+  N R P FL+ L  L     K I   QE + N +   S+          +
Sbjct: 611  IDTFVTLVRKN-REPRFLDYLSDLCVSMQKSIPVTQELICNAVLDPSNADILIETKLVLS 669

Query: 4330 QLYVDNASFEELEAMMKDE-----------KESKGRS-----SDSRRKLKYHIELV---- 4449
            +  ++ AS  E     +DE           KE + +S      D++   K  +E+V
Sbjct: 670  RFEIETASNGESPVEAEDEEEVWLFWKDNCKEIRSKSIRELAQDAKEGQKEDLEVVSYYR 729

Query: 4450 ---RLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDA 4620
                L A     +      K + Q+ +D I+R ++ +    +++  + +L+LH ++D D
Sbjct: 730  CQLNLFARMCLDRQYLAINKISGQLDVDLILRCMSDEDLPFDLRASFCRLMLHMHVDRDP 789

Query: 4621 E 4623
            +
Sbjct: 790  Q 790


>gi|21362620|sp||Q9Z329_2 [Segment 2 of 2] Inositol
            1,4,5-trisphosphate receptor type 2 (Type 2 inositol
            1,4,5-trisphosphate receptor) (Type 2 InsP3 receptor)
            (IP3 receptor isoform 2) (InsP3R2) (Inositol
            1,4,5-trisphosphate type V receptor)
 gi|1495696|emb|CAA94861.1| inositol 1,4,5-trisphosphate receptor type
            2 [Mus musculus]
          Length = 1009

 Score =  667 bits (1721), Expect = 0.0
 Identities = 391/1004 (38%), Positives = 569/1004 (55%), Gaps = 30/1004 (2%)
 Frame = +1

Query: 5638 IQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHE 5817
            IQC L+  GAS+LV D+I+   +  IF + I L  ALL  GN + Q+SFY ++ ++   E
Sbjct: 53   IQCLLDKEGASELVIDVIVNTKNDRIFSEGILLGIALLEGGNTQTQYSFYQQLHEQKKSE 112

Query: 5818 PFFKAILTRIQTAQNRLKSDM----MSCSDSKPKVSSTVLT--PLIDAGDT------GFN 5961
             FFK +  R++ AQ  ++S +    +     K +  S V+   P +   D+      G
Sbjct: 113  KFFKVLYDRMKAAQKEIRSTVTVNTIDLGSKKREEDSDVMALGPRMRVRDSSLHLREGMK 172

Query: 5962 GALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTD--ALPPEVALVEPILRV 6135
            G L E              ++  ++    P       EEKS +   + P + ++ PILR
Sbjct: 173  GQLTEASSATSKAYCVYRREMDPEIDTMCPGQEAGSAEEKSAEEVTMSPAITIMRPILRF 232

Query: 6136 LQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFG-EIGEHNFSL 6312
            LQLLCENHN  LQNFLR Q+++TN+NLV ETL FLD +CGST G LG+ G  I E N +L
Sbjct: 233  LQLLCENHNRELQNFLRNQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINERNVAL 292

Query: 6313 ITQTLATLTEFCQGPCHENQNTMAMQE-NGLNIIISLVLNEIKPLADDHMELALEIKSQA 6489
            + QTL +LTE+CQGPCHENQ  +A  E NG++III+L+LN+I PL    M+L L++K+ A
Sbjct: 293  VNQTLESLTEYCQGPCHENQTCIATHESNGIDIIIALILNDINPLGKYRMDLVLQLKNNA 352

Query: 6490 SKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDLF 6669
            S                              K L+  ++  ++  N+   +     R+L
Sbjct: 353  S------------------------------KLLLAIMESRHDSENAERILFNMRPRELV 382

Query: 6670 RQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDPR 6849
                 D+ K +  Q                G+   H         D++  DD    V P+
Sbjct: 383  -----DVMKNAYNQ----------------GLECDHG--------DEEGGDD---GVSPK 410

Query: 6850 EVGHNIYILAHQLAIHDGELEIWLD-GSDEKKDDLTREALNYYKERTAQIEIVRRDRTLE 7026
            +VGHNIYILAHQLA H+  L+  L  GSD ++ D   EAL YY   TAQIEIVR DRT+E
Sbjct: 411  DVGHNIYILAHQLARHNKLLQQMLKPGSDPEEGD---EALKYYANHTAQIEIVRHDRTME 467

Query: 7027 RVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWL 7206
            ++VFP+ +IC +LT+++K  V+N TERD QGSKV + F + E +Y+EM WQ+K+++   L
Sbjct: 468  QIVFPVPNICEFLTRESKYRVFNTTERDEQGSKVNDLFQQTEDLYNEMKWQKKIRNNPAL 527

Query: 7207 SWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYS---WFAV-FSSFLL 7374
             W +  + LW  +SF+ A  +N  VA +YP  +  +   +L  ++S   W AV   + +L
Sbjct: 528  FWFSRHISLWGSISFNLAVFINLAVALFYPFGDDGDEG-TLSPMFSALLWVAVAICTSML 586

Query: 7375 AHYLRHDKIYLHKTXXXXXXXXXXXXXXXIGVTLTLYIFGILQLVNKIVHVVAFVSNKGL 7554
              + +   I                    IG+  TL + G   L NKIV +V+FV N+G
Sbjct: 587  FFFSKPVGI------RPFLVSVMLRSIYTIGLGPTLILLGAANLCNKIVFLVSFVGNRGT 640

Query: 7555 EDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNY 7734
              R    ++      Y + Y+ +C+LGL VH   Y  LLFD+++ EETL NVI SVTRN
Sbjct: 641  FTRGYRAVILDMAFLYHVAYVLVCMLGLFVHEFFYSFLLFDLVYREETLLNVIKSVTRNG 700

Query: 7735 QSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPS-------ETC 7893
            +SI+ T +LALIL+Y FSI+GFL+ + DF +EVD ++N +  T + G+P+       ETC
Sbjct: 701  RSIILTAVLALILVYLFSIIGFLFLKDDFTMEVDRLKNRTPVTGNHGVPTMTLSSMMETC 760

Query: 7894 PSEGCPGLQPSXXXXXXXXXXXX--SCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWED 8067
              E C    PS              +C+TL MCI+    QGLRNGGG+GDVLR P+  E
Sbjct: 761  QKENCSPTIPSSNTAGEEGEDGIERTCDTLLMCIVTVLNQGLRNGGGVGDVLRRPSKDEP 820

Query: 8068 MFIWRVAYDMTXXXXXXXXXXXXXXXXXXDTFGDLRAEKNEKEQILKNNCFICGLDRSRF 8247
            +F  RV YD+                   DTF DLR+EK +KE+ILK  CFICGL+R +F
Sbjct: 821  LFAARVVYDLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKF 880

Query: 8248 DNRSVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQAL 8427
            DN++V+FE H ++EHN+WHYLY+IV++++KD TE+TGPESYVAQ + ++NLDWFPRM+A+
Sbjct: 881  DNKTVSFEEHIKSEHNMWHYLYFIVLVKVKDPTEYTGPESYVAQMITEKNLDWFPRMRAM 940

Query: 8428 SLQDSELDTDQSEVKQMKDQLLQMMTLMREIISQNEESRAFMEQ 8559
            SL  +E D++Q+E++ ++++L   M+L++++  Q  E +  M +
Sbjct: 941  SLVSNEGDSEQNEIRNLQEKLESTMSLVKQLSGQLAELKEQMTE 984


>gi|26339686|dbj|BAC33514.1| unnamed protein product [Mus musculus]
          Length = 1004

 Score =  657 bits (1694), Expect = 0.0
 Identities = 415/1026 (40%), Positives = 591/1026 (57%), Gaps = 45/1026 (4%)
 Frame = +1

Query: 259  DCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLG 438
            DCLFK+CP+NRY+AQK  W   K     +S  D  L+NKL  AAD E+++NE+E +K LG
Sbjct: 5    DCLFKLCPMNRYSAQKQFWKAAK--PGANSTTDAVLLNKLHHAADLEKKQNETENRKLLG 62

Query: 439  NVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAI 618
             VIQYG+++QLLH+KSNKY+TV K  PA  E+NAM+V LD AGNEGSWF I+P YK  +I
Sbjct: 63   TVIQYGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSI 122

Query: 619  GDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFL 798
            GD+V  G+K+ L P       AG     LH SS  L+D+    EVN +N  T W++ +F+
Sbjct: 123  GDSVVIGDKVVLNP-----VNAG---QPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFM 174

Query: 799  LFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRA 978
             + +N+ + +K GDVVRLFHA+Q+ FLT D   K+      VFLR T R SA  ATSS+A
Sbjct: 175  KWSDNKDDILKGGDVVRLFHAEQEKFLTCDEHRKKQH----VFLRTTGRQSATSATSSKA 230

Query: 979  LWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRPPLLSALSQK 1158
            LWEV+VVQ +  RGG   WN  +RFKHLAT  YL+AE      +  +  +P  +
Sbjct: 231  LWEVEVVQHDPCRGGAGYWNSLFRFKHLATGHYLAAEVDPDFEEECLEFQPS-VDPDQDA 289

Query: 1159 SRPMLERTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPE-EDANLLFQLD 1335
            SR  L      M +YS                 + SV          PE  D + +F+LD
Sbjct: 290  SRSRLRNAQEKM-VYS-----------------LVSV----------PEGNDISSIFELD 321

Query: 1336 PSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKG-WVKVICEKNRV 1512
            P+T    +  VPR SYVRL H  ++ WVH+T      N+    + EK   +K+     +
Sbjct: 322  PTTLRGGDSLVPRNSYVRLRHLCTNTWVHST------NIPIDKEEEKPVMLKIGTSPLKE 375

Query: 1513 DKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFV 1692
            DKE FA++PV+P EVRDLDFANDA K L +    ++ G +   E   S T+LL D + FV
Sbjct: 376  DKEAFAIVPVSPAEVRDLDFANDASKVLGSIAGKLEKGTITQNER-RSVTKLLEDLVYFV 434

Query: 1693 TNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTXXXXXXXXXX 1872
            T  ++   D L++    P+R+RQKL+REQ +L Q+F LL+APF     T
Sbjct: 435  TGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQIFKLLQAPF-----TDCGDGPMLRLE 489

Query: 1873 XXXDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVL 2052
               D R+  F+ + +LCY +L++SQ  YRKNQE++A++FG +Q+QIG+D++AEDT+TA+L
Sbjct: 490  ELGDQRHAPFRHICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALL 549

Query: 2053 HNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSS 2232
            HNN KLLEK++    ++ FV LVR NR+ +FLDYL+DLCV   ++    QELIC +VL+
Sbjct: 550  HNNRKLLEKHITAAEIDTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNP 609

Query: 2233 KHRDIFMDTKII---------------------DGEIEVGWAPNFRKL-----VDIAEGA 2334
             + DI ++TK++                     + E+ + W  + +++      ++A+ A
Sbjct: 610  TNADILIETKLVLSRFEFEGVSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDA 669

Query: 2335 K-SNSDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDN 2511
            K    +D + L YYR+QL+L ++MC ++QYLAI+         IS QL  +L+L+CMSD
Sbjct: 670  KEGQKEDRDILSYYRYQLNLFARMCLDRQYLAIN--------EISGQLDVDLILRCMSDE 721

Query: 2512 RLPYDLRGSFTRLMLHLHVVRG--SPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGS 2685
             LPYDLR SF RLMLH+HV R     ++ +++ARLW  IP  + +  Y+S      S  S
Sbjct: 722  NLPYDLRASFCRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDS------SGTS 775

Query: 2686 RMRIGEGIAHKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFND 2865
            +  I E  A + +  VE YL  +  Q          +KLT+E+VNLA+ L  F FY+F+D
Sbjct: 776  KDEIKERFA-QTMEFVEEYLRDVVCQRFPFSDK-EKNKLTFEVVNLARNLIYFGFYNFSD 833

Query: 2866 LLQLTQNLLAIINEGPATEQVPSHRAM-------VNAIRN-------MSKSMMRGGNKEN 3003
            LL+LT+ LLAI++    T   P  +          N +R+       M++ ++RGG
Sbjct: 834  LLRLTKILLAILDCVHVTTIFPISKMTKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLP 893

Query: 3004 SKDLAKTPSVTAEEAGRTKEGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFP 3183
               +A  P    ++A   KE   + + TKL + EILQF+++VR DYRI+  L  FK  F
Sbjct: 894  MTPMAAAPEGNVKQAEPEKED-IMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREF- 951

Query: 3184 CDEDGS 3201
             DE  S
Sbjct: 952  -DESNS 956

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