Homology by BLASTX
BLASTX 2.2.4 [Aug-26-2002]
Query= F54D1_5
(4092 letters)
Database: /home/niguts/usr02/tshini/ykclst/db/nr.seq
1,967,186 sequences; 661,712,633 total letters
Score E
Sequences producing significant alignments: (bits) Value
gi|7504163|pir||T22644 hypothetical protein F54D1.5 - Caenorhabd... 2686 0.0
gi|15718227|emb|CAB00861.2| C. elegans GTL-2 protein (correspond... 2686 0.0
gi|39593744|emb|CAE62037.1| Hypothetical protein CBG06053 [Caeno... 2503 0.0
gi|32565923|ref|NP_502118.2| Gon-Two Like, TRP subfamily (gtl-2)... 2200 0.0
gi|50511021|dbj|BAD32496.1| mKIAA1616 protein [Mus musculus] 759 0.0
gi|30141363|emb|CAD43605.1| long transient receptor potential ch... 758 0.0
gi|48104806|ref|XP_395849.1| similar to ENSANGP00000005757 [Apis... 730 0.0
gi|31199943|ref|XP_308919.1| ENSANGP00000005757 [Anopheles gambi... 730 0.0
gi|47214189|emb|CAG00817.1| unnamed protein product [Tetraodon n... 721 0.0
gi|19922314|ref|NP_611026.1| CG30078-PA [Drosophila melanogaster... 715 0.0
gi|29893552|ref|NP_060142.2| transient receptor potential cation... 702 0.0
gi|13959785|gb|AAK44211.1| LTRPC7 [Homo sapiens] 702 0.0
gi|50753109|ref|XP_425074.1| PREDICTED: similar to transient rec... 695 0.0
gi|10946830|ref|NP_067425.1| transient receptor potential cation... 691 0.0
gi|14211383|gb|AAK57433.1| transient receptor potential phosphol... 691 0.0
gi|14009344|gb|AAK50377.1| LTRPC7 [Mus musculus] 691 0.0
gi|45935360|ref|NP_996827.1| transient receptor potential cation... 687 0.0
gi|27597209|dbj|BAC55104.1| hypothetical protein [Homo sapiens] 687 0.0
gi|45935362|ref|NP_996828.1| transient receptor potential cation... 686 0.0
gi|47214200|emb|CAG00828.1| unnamed protein product [Tetraodon n... 685 0.0
gi|28274684|ref|NP_066003.1| transient receptor potential cation... 684 0.0
gi|45935358|ref|NP_079247.3| transient receptor potential cation... 683 0.0
gi|34861963|ref|XP_219747.2| similar to transient receptor poten... 681 0.0
gi|28626251|gb|AAO49155.1| calcium-permeable store-operated chan... 679 0.0
gi|24653815|ref|NP_725447.1| CG30078-PB [Drosophila melanogaster... 678 0.0
gi|37790764|gb|AAR03488.1| transient receptor potential cation c... 678 0.0
gi|18921093|ref|NP_060132.3| transient receptor potential cation... 677 0.0
gi|37790766|gb|AAR03489.1| transient receptor potential cation c... 677 0.0
gi|37790768|gb|AAR03490.1| truncated transient receptor potentia... 677 0.0
gi|45935366|ref|NP_996830.1| transient receptor potential cation... 677 0.0
gi|27597207|dbj|BAC55103.1| hypothetical protein [Homo sapiens] 677 0.0
gi|23510305|ref|NP_700466.1| transient receptor potential cation... 676 0.0
gi|45935364|ref|NP_996829.1| transient receptor potential cation... 674 0.0
gi|27597213|dbj|BAC55106.1| hypothetical protein [Homo sapiens] 660 0.0
gi|50752897|ref|XP_425066.1| PREDICTED: similar to transient rec... 641 0.0
gi|50761814|ref|XP_429161.1| PREDICTED: similar to transient rec... 597 e-169
gi|47225840|emb|CAF98320.1| unnamed protein product [Tetraodon n... 584 e-165
gi|24412718|emb|CAC81667.1| putative TRP homologous cation chann... 565 e-159
gi|32565925|ref|NP_502111.2| Gon-Two Like, TRP subfamily (gtl-1)... 565 e-159
gi|30145746|emb|CAA92726.2| Hypothetical protein C05C12.3 [Caeno... 565 e-159
gi|7495413|pir||T18951 hypothetical protein C05C12.3 - Caenorhab... 565 e-159
gi|39593737|emb|CAE62030.1| Hypothetical protein CBG06044 [Caeno... 555 e-156
gi|26336493|dbj|BAC31929.1| unnamed protein product [Mus musculus] 475 e-132
gi|10439092|dbj|BAB15429.1| unnamed protein product [Homo sapiens] 451 e-125
gi|7506920|pir||T23707 hypothetical protein T01H8.5 - Caenorhabd... 443 e-122
gi|33112467|sp|Q93971|TRPG_CAEEL Transient receptor potential ch... 443 e-122
gi|32563751|ref|NP_492315.3| abnormal GONad development GON-2, p... 443 e-122
gi|39595604|emb|CAE67105.1| Hypothetical protein CBG12518 [Caeno... 442 e-122
gi|24412720|emb|CAC81668.1| putative TRP homologous cation chann... 442 e-122
gi|50761777|ref|XP_424831.1| PREDICTED: similar to long transien... 426 e-117
gi|33235694|dbj|BAC80204.1| melastatin 1 splicing variant [Homo ... 410 e-112
gi|3243075|gb|AAC80000.1| melastatin 1 [Homo sapiens] 410 e-112
gi|21450859|ref|NP_002411.2| transient receptor potential cation... 410 e-112
gi|33235686|dbj|BAC80200.1| melastatin 1 [Homo sapiens] 410 e-112
gi|26342260|dbj|BAC34792.1| unnamed protein product [Mus musculus] 409 e-112
gi|33235688|dbj|BAC80201.1| melastatin 1 [Homo sapiens] 407 e-112
gi|50752088|ref|XP_422646.1| PREDICTED: similar to transient rec... 405 e-111
gi|34862088|ref|XP_219902.2| similar to hypothetical protein [Ra... 404 e-111
gi|47210870|emb|CAF92603.1| unnamed protein product [Tetraodon n... 400 e-109
gi|21314671|ref|NP_060106.2| transient receptor potential cation... 379 e-103
gi|32487286|emb|CAE05940.1| transient receptor potential ion cha... 374 e-101
gi|7020006|dbj|BAA90958.1| unnamed protein product [Homo sapiens] 373 e-101
gi|47208258|emb|CAF91479.1| unnamed protein product [Tetraodon n... 355 4e-96
gi|37790770|gb|AAR03491.1| M6-kinase 1 [Homo sapiens] 354 1e-95
gi|34856313|ref|XP_341869.1| similar to transient receptor poten... 338 5e-91
gi|37790772|gb|AAR03492.1| M6-kinase 2 [Homo sapiens] 338 8e-91
gi|16416145|emb|CAD01139.1| putative TRP cation channel [Homo sa... 332 6e-89
gi|7768779|dbj|BAA95563.1| transient receptor potential-related ... 330 1e-88
gi|4507689|ref|NP_003298.1| transient receptor potential cation ... 330 1e-88
gi|47575895|ref|NP_001001188.1| transient receptor potential cat... 330 1e-88
gi|34852365|ref|XP_228069.2| similar to transient receptor poten... 322 4e-86
gi|31083376|ref|NP_612174.1| transient receptor potential cation... 319 4e-85
gi|6723520|emb|CAB66342.1| LTRPC5 protein [Homo sapiens] 315 7e-84
gi|11225266|ref|NP_055370.1| transient receptor potential cation... 314 1e-83
gi|34861772|ref|XP_344980.1| similar to MLSN1- and TRP-related p... 312 4e-83
gi|8777450|dbj|BAA96877.1| MLSN1- and TRP-related protein 1 [Mus... 311 6e-83
gi|12383054|ref|NP_064673.1| transient receptor potential cation... 311 6e-83
gi|11967809|emb|CAC19456.1| Ltrpc5 protein [Mus musculus] 311 6e-83
gi|11967810|emb|CAC19457.1| Ltrpc5 protein [Mus musculus] 311 6e-83
gi|50747866|ref|XP_421023.1| PREDICTED: similar to transient rec... 308 5e-82
gi|20537335|sp|Q9HCF6|TRL3_HUMAN Long transient receptor potenti... 303 2e-80
gi|29171322|ref|NP_780339.1| transient receptor potential cation... 302 5e-80
gi|31335335|gb|AAP44475.1| transient receptor potential cation c... 297 1e-78
gi|31335145|gb|AAP44477.1| transient receptor potential cation c... 296 4e-78
gi|11993700|gb|AAG42856.1| melastatin 2 [Homo sapiens] 289 4e-76
gi|33417094|gb|AAH56004.1| LOC398685 protein [Xenopus laevis] 286 2e-75
gi|26340044|dbj|BAC33685.1| unnamed protein product [Mus musculus] 286 2e-75
gi|26449301|dbj|BAC41778.1| hypothetical protein [Macaca fascicu... 283 3e-74
gi|47228179|emb|CAG07574.1| unnamed protein product [Tetraodon n... 281 1e-73
gi|45709181|gb|AAH67733.1| TRPM3 protein [Homo sapiens] 280 3e-73
gi|34783897|gb|AAH22454.2| TRPM3 protein [Homo sapiens] 280 3e-73
gi|26342364|dbj|BAC34844.1| unnamed protein product [Mus musculus] 279 3e-73
gi|26342304|dbj|BAC34814.1| unnamed protein product [Mus musculus] 279 3e-73
gi|26351079|dbj|BAC39176.1| unnamed protein product [Mus musculus] 279 3e-73
gi|15617229|gb|AAL02142.1| TRP-related cation influx channel [Ho... 277 1e-72
gi|7019879|dbj|BAA90907.1| unnamed protein product [Homo sapiens] 277 1e-72
gi|3047242|gb|AAC13683.1| melastatin [Mus musculus] 274 1e-71
gi|38086815|ref|XP_358370.1| transient receptor potential cation... 273 2e-71
gi|19570794|dbj|BAB86335.1| LTRPC6 [Homo sapiens] 265 7e-69
gi|32966583|gb|AAP92167.1| transient receptor potential subfamil... 265 7e-69
gi|21361691|ref|NP_076985.3| transient receptor potential cation... 265 9e-69
gi|19527416|ref|NP_599013.1| transient receptor potential cation... 262 6e-68
gi|19705471|ref|NP_599198.1| cold/menthol receptor 1 [Rattus nor... 261 1e-67
gi|12852708|dbj|BAB29509.1| unnamed protein product [Mus musculus] 261 1e-67
gi|50750125|ref|XP_421881.1| PREDICTED: similar to transient rec... 260 2e-67
gi|26330492|dbj|BAC28976.1| unnamed protein product [Mus musculus] 249 3e-64
gi|30046835|gb|AAH51024.1| Similar to transient receptor potenti... 248 1e-63
gi|12052728|emb|CAB66480.1| hypothetical protein [Homo sapiens] 241 1e-61
gi|34862086|ref|XP_342036.1| similar to transient receptor poten... 241 1e-61
gi|47226315|emb|CAG09283.1| unnamed protein product [Tetraodon n... 236 3e-60
gi|37590435|gb|AAH58632.1| Trpm4 protein [Mus musculus] 224 1e-56
gi|45935368|ref|NP_996831.1| transient receptor potential cation... 215 6e-54
gi|33235690|dbj|BAC80202.1| melastatin 1 splicing variant [Homo ... 215 6e-54
gi|49118014|gb|AAH72955.1| LOC398685 protein [Xenopus laevis] 210 3e-52
gi|47230747|emb|CAF99940.1| unnamed protein product [Tetraodon n... 207 2e-51
gi|9929957|dbj|BAB12135.1| hypothetical protein [Macaca fascicul... 204 1e-50
gi|28385940|gb|AAH46472.1| Trpm4 protein [Mus musculus] 198 8e-49
gi|37790774|gb|AAR03493.1| M6-kinase 3 [Homo sapiens] 198 8e-49
gi|16553674|dbj|BAB71558.1| unnamed protein product [Homo sapiens] 197 2e-48
gi|47215300|emb|CAG01605.1| unnamed protein product [Tetraodon n... 169 5e-40
gi|10433044|dbj|BAB13895.1| unnamed protein product [Homo sapiens] 167 3e-39
gi|28479403|ref|XP_145667.2| similar to transient receptor poten... 127 2e-27
gi|47205617|emb|CAF94442.1| unnamed protein product [Tetraodon n... 108 8e-22
gi|47210869|emb|CAF92602.1| unnamed protein product [Tetraodon n... 106 5e-21
gi|12654599|gb|AAH01135.1| TRPM8 protein [Homo sapiens] >gnl|BL_... 104 2e-20
gi|47230746|emb|CAF99939.1| unnamed protein product [Tetraodon n... 103 3e-20
gi|42742434|gb|AAS45275.1| short transient receptor potential su... 102 8e-20
gi|33636395|dbj|BAC81770.1| transient receptor potential cation ... 101 2e-19
gi|29612563|gb|AAH49993.1| Trpm4 protein [Mus musculus] 101 2e-19
gi|10566461|dbj|BAB15808.1| melastatin like 2 [Rattus norvegicus] 97 4e-18
gi|34856318|ref|XP_341870.1| similar to transient receptor poten... 80 3e-13
gi|28385937|gb|AAH46537.1| Trpm4 protein [Mus musculus] 73 6e-11
gi|33636393|dbj|BAC81769.1| transient receptor potential cation ... 70 3e-10
gi|47077801|dbj|BAD18773.1| unnamed protein product [Homo sapiens] 65 1e-08
gi|39585119|emb|CAE62770.1| Hypothetical protein CBG06939 [Caeno... 60 6e-07
gi|23123868|ref|ZP_00105901.1| hypothetical protein [Nostoc punc... 53 5e-05
gi|17229066|ref|NP_485614.1| unknown protein [Nostoc sp. PCC 712... 52 1e-04
gi|16444883|emb|CAC81659.1| putative TRP homologous cation chann... 50 3e-04
gi|17552730|ref|NP_499021.1| CEll Death abnormality CED-11, TRP ... 50 3e-04
gi|34849478|gb|AAH58286.1| Unknown (protein for IMAGE:6673722) [... 48 0.002
gi|34555944|emb|CAA94592.2| Hypothetical protein F13B12.3 [Caeno... 45 0.014
gi|34330186|ref|NP_899192.1| transient receptor potential cation... 44 0.025
gi|171959|gb|AAA34783.1| myosin-like protein 41 0.21
gi|6322948|ref|NP_013021.1| Mlp proteins restrict telomere lengt... 41 0.21
gi|33300056|emb|CAE17694.1| Hypothetical protein C12D8.13 [Caeno... 41 0.27
gi|15899050|ref|NP_343655.1| NADH oxidase [Sulfolobus solfataric... 40 0.36
gi|26553606|ref|NP_757540.1| predicted cytoskeletal protein [Myc... 40 0.36
gi|39581476|emb|CAE68006.1| Hypothetical protein CBG13617 [Caeno... 40 0.36
gi|17510427|ref|NP_493429.1| predicted CDS, mechanosensory trans... 39 0.79
gi|4885583|ref|NP_005397.1| Rho-associated, coiled-coil containi... 39 0.79
gi|17998549|ref|NP_523483.1| CG11020-PA [Drosophila melanogaster... 39 0.79
gi|47605987|sp|P61584|ROC1_PANTR Rho-associated protein kinase 1... 39 0.79
gi|50731137|ref|XP_417184.1| PREDICTED: similar to putative capa... 39 0.79
gi|45552223|ref|NP_995634.1| CG11020-PB [Drosophila melanogaster... 39 0.79
gi|47222552|emb|CAG02917.1| unnamed protein product [Tetraodon n... 39 1.0
gi|47221103|emb|CAG12797.1| unnamed protein product [Tetraodon n... 39 1.0
gi|23509023|ref|NP_701691.1| hypothetical protein [Plasmodium fa... 39 1.4
gi|23509279|ref|NP_701946.1| hypothetical protein [Plasmodium fa... 39 1.4
gi|31203635|ref|XP_310766.1| ENSANGP00000014854 [Anopheles gambi... 39 1.4
gi|12802208|gb|AAK07770.1| unknown [Babesia bovis] 38 1.8
gi|39591656|emb|CAE71233.1| Hypothetical protein CBG18103 [Caeno... 38 1.8
gi|48095512|ref|XP_392309.1| similar to CG11020-PB [Apis mellifera] 38 1.8
gi|11120728|ref|NP_068539.1| ion channel protein [Rattus norvegi... 38 1.8
gi|37359685|emb|CAE47766.1| SI:bZ1P14.9 (novel protein similar t... 38 1.8
gi|20988520|gb|AAH30436.1| 8430438L13Rik protein [Mus musculus] 38 1.8
gi|2133394|pir||S61535 nucleotide-binding head-stalk protein 183... 38 1.8
gi|29248170|gb|EAA39711.1| GLP_741_55154_50292 [Giardia lamblia ... 38 1.8
gi|31197759|ref|XP_307827.1| ENSANGP00000017234 [Anopheles gambi... 38 2.3
gi|32564336|ref|NP_498881.2| transient Receptor Potential channe... 38 2.3
gi|33304289|gb|AAQ02629.1| transient receptor potential channel ... 38 2.3
gi|7447160|pir||JC5807 trp3 protein - rat 38 2.3
gi|85171|pir||JU0092 trp protein - fruit fly (Drosophila melanog... 38 2.3
gi|1620935|emb|CAB02410.1| Trp protein [Calliphora vicina] 38 2.3
gi|1174798|sp|P19334|TRP_DROME Transient receptor potential prot... 38 2.3
gi|17136554|ref|NP_476768.1| CG7875-PA [Drosophila melanogaster]... 38 2.3
gi|6755889|ref|NP_036165.1| transient receptor potential cation ... 38 2.3
gi|85170|pir||JN0015 trp protein - fruit fly (Drosophila melanog... 38 2.3
gi|600514|gb|AAA56928.1| photoreceptor membrane-associated protein 38 2.3
gi|42740995|gb|AAS44576.1| TRP2 ion channel [Alouatta belzebul] 38 2.3
gi|42740997|gb|AAS44577.1| TRP2 ion channel [Alouatta palliata] 38 2.3
gi|42740999|gb|AAS44578.1| TRP2 ion channel [Alouatta seniculus] 38 2.3
gi|630741|pir||S44873 ZC21.2 protein - Caenorhabditis elegans 38 2.3
gi|50752552|ref|XP_422827.1| PREDICTED: similar to Myosin heavy ... 37 3.0
gi|15791066|ref|NP_280890.1| N-ethylammeline chlorohydrolase; Tr... 37 3.0
gi|9967846|emb|CAC06051.2| putative capacitative calcium entry c... 37 3.0
gi|26328139|dbj|BAC27810.1| unnamed protein product [Mus musculus] 37 3.0
gi|4507687|ref|NP_003296.1| transient receptor potential cation ... 37 3.0
gi|47933429|gb|AAT39342.1| calcium transporter 2 [Oikopleura dio... 37 3.0
gi|5730102|ref|NP_004612.2| transient receptor potential cation ... 37 3.0
gi|7494300|pir||G71611 hypothetical protein PFB0560w - malaria p... 37 3.0
gi|39582797|emb|CAE74260.1| Hypothetical protein CBG21950 [Caeno... 37 3.0
gi|50746873|ref|XP_426322.1| PREDICTED: similar to Short transie... 37 3.0
gi|9507207|ref|NP_062383.1| transient receptor potential cation ... 37 3.0
gi|26348643|dbj|BAC37961.1| unnamed protein product [Mus musculus] 37 3.0
gi|23593303|ref|NP_473041.2| hypothetical protein [Plasmodium fa... 37 3.0
gi|33304274|gb|AAQ02628.1| transient receptor potential channel ... 37 3.0
gi|33304334|gb|AAQ02632.1| transient receptor potential channel ... 37 3.0
gi|33304319|gb|AAQ02631.1| transient receptor potential channel ... 37 3.0
gi|11095639|gb|AAG29950.1| transient receptor potential channel ... 37 3.9
gi|6755887|ref|NP_035774.1| transient receptor potential cation ... 37 3.9
gi|12018338|ref|NP_072160.1| transient receptor potential cation... 37 3.9
gi|34392424|dbj|BAC82538.1| trp6 [Cavia porcellus] 37 3.9
gi|23509391|ref|NP_702058.1| hypothetical protein [Plasmodium fa... 37 3.9
gi|9967888|emb|CAC06427.1| TRPC6 cation channel, putative altern... 37 3.9
gi|9967886|emb|CAC06426.1| TRPC6 cation channel, putative altern... 37 3.9
gi|4324938|gb|AAD17195.1| transient receptor potential 2 [Mus mu... 37 3.9
gi|33304304|gb|AAQ02630.1| transient receptor potential channel ... 37 3.9
gi|11095641|gb|AAG29951.1| transient receptor potential channel ... 37 3.9
gi|34392422|dbj|BAC82537.1| trp3 [Cavia porcellus] 37 5.1
gi|23612336|ref|NP_703916.1| hypothetical protein [Plasmodium fa... 36 6.7
gi|18376629|emb|CAD19069.1| short transient receptor potential c... 36 6.7
gi|9966865|ref|NP_065122.1| putative capacitative calcium channe... 36 6.7
gi|19684076|gb|AAH25988.1| Leucine zipper transcription factor-l... 36 8.8
gi|23612199|ref|NP_703779.1| hypothetical protein [Plasmodium fa... 36 8.8
gi|8980369|emb|CAB96873.1| leucine zipper transcription factor-l... 36 8.8
gi|46134013|ref|XP_389322.1| hypothetical protein FG09146.1 [Gib... 36 8.8
gi|14588885|emb|CAA70302.1| asparagine-rich protein [Plasmodium ... 36 8.8
gi|23480634|gb|EAA17141.1| hypothetical protein [Plasmodium yoel... 36 8.8
gi|34877522|ref|XP_341410.1| similar to 8430438L13Rik protein [R... 36 8.8
gi|16799897|ref|NP_470165.1| similar to transport protein (trunc... 36 8.8
gi|33086618|gb|AAP92621.1| Ac2-154 [Rattus norvegicus] 36 8.8
gi|23508404|ref|NP_701073.1| hypothetical protein [Plasmodium fa... 36 8.8
gi|13592049|ref|NP_112360.1| Rho-associated kinase beta [Rattus ... 36 8.8
gi|23491382|gb|EAA22927.1| hypothetical protein [Plasmodium yoel... 36 8.8
>gi|7504163|pir||T22644 hypothetical protein F54D1.5 - Caenorhabditis
elegans
Length = 1400
Score = 2686 bits (6962), Expect = 0.0
Identities = 1327/1363 (97%), Positives = 1327/1363 (97%)
Frame = +1
Query: 1 MCNANTVHSISSFRSDHLSRKSTHKFLDNPNLFAIELTEKLSPPWIENTFEKRECIRFAA 180
MCNANTVHSISSFRSDHLSRKSTHKFLDNPNLFAIELTEKLSPPWIENTFEKRECIRFAA
Sbjct: 38 MCNANTVHSISSFRSDHLSRKSTHKFLDNPNLFAIELTEKLSPPWIENTFEKRECIRFAA 97
Query: 181 LPKDPERCGCGRPLSAHTPASTFFSTLPVHLLEKEQQTWTIANNTQTSTTDAFGTIVFQG 360
LPKDPERCGCGRPLSAHTPASTFFSTLPVHLLEKEQQTWTIANNTQTSTTDAFGTIVFQG
Sbjct: 98 LPKDPERCGCGRPLSAHTPASTFFSTLPVHLLEKEQQTWTIANNTQTSTTDAFGTIVFQG 157
Query: 361 GAHAHKAQYVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGMSNFELEERLGRLFRKG 540
GAHAHKAQYVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGMSNFELEERLGRLFRKG
Sbjct: 158 GAHAHKAQYVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGMSNFELEERLGRLFRKG 217
Query: 541 MLKAAQTTGAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLI 720
MLKAAQTTGAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLI
Sbjct: 218 MLKAAQTTGAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLI 277
Query: 721 RQNEHVYYDVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCN 900
RQNEHVYYDVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCN
Sbjct: 278 RQNEHVYYDVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCN 337
Query: 901 GRKVPVVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFA 1080
GRKVPVVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFA
Sbjct: 338 GRKVPVVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFA 397
Query: 1081 AEVGEKLRNLIKMVFPETDQEEMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQ 1260
AEVGEKLRNLIKMVFPETDQEEMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQ
Sbjct: 398 AEVGEKLRNLIKMVFPETDQEEMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQ 457
Query: 1261 KQNLPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLEN 1440
KQNLPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLEN
Sbjct: 458 KQNLPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLEN 517
Query: 1441 GVSMKNFLSINRLENLYNMDDINSAHSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNA 1620
GVSMKNFLSINRLENLYNMDDINSAHSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNA
Sbjct: 518 GVSMKNFLSINRLENLYNMDDINSAHSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNA 577
Query: 1621 FQLYYTSRSFKGKYDRYKRINQSSYFHRKRKIVQKELFKKKSDDQINDNEEEDFSFAYPF 1800
FQLYYTSRSFKGKYDRYKRINQSSYFHRKRKIVQKELFKKKSDDQINDNEEEDFSFAYPF
Sbjct: 578 FQLYYTSRSFKGKYDRYKRINQSSYFHRKRKIVQKELFKKKSDDQINDNEEEDFSFAYPF 637
Query: 1801 NDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEEAKRLFDN 1980
NDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEEAKRLFDN
Sbjct: 638 NDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEEAKRLFDN 697
Query: 1981 AVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPCCQIL 2160
AVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPCCQIL
Sbjct: 698 AVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPCCQIL 757
Query: 2161 LAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQLPYPRESI 2340
LAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQLPYPRESI
Sbjct: 758 LAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQLPYPRESI 817
Query: 2341 TSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKNXXXXXXXXXXXXXXFKREPQL 2520
TSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKN FKREPQL
Sbjct: 818 TSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKNSGVASVYGSASSMMFKREPQL 877
Query: 2521 NKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIYTVTLSVE 2700
NKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIYTVTLSVE
Sbjct: 878 NKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIYTVTLSVE 937
Query: 2701 HIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSWGRVLLSFS 2880
HIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSWGRVLLSFS
Sbjct: 938 HIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSWGRVLLSFS 997
Query: 2881 NVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEPNVKD 3060
NVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEPNVKD
Sbjct: 998 NVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEPNVKD 1057
Query: 3061 WHWLLVRNIFYKPYFMLYGEVYAGEIDTCGDEGIRCFPGYFIPPLLMXXXXXXXXXXXXX 3240
WHWLLVRNIFYKPYFMLYGEVYAGEIDTCGDEGIRCFPGYFIPPLLM
Sbjct: 1058 WHWLLVRNIFYKPYFMLYGEVYAGEIDTCGDEGIRCFPGYFIPPLLMVIFLLVANILLLN 1117
Query: 3241 XXXXXXXXXYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDYLYNLRR 3420
YNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDYLYNLRR
Sbjct: 1118 LLIAIFNNIYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDYLYNLRR 1177
Query: 3421 PDTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTLTRIRKLKLNTKEPLSVTDLTELTCQ 3600
PDTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTLTRIRKLKLNTKEPLSVTDLTELTCQ
Sbjct: 1178 PDTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTLTRIRKLKLNTKEPLSVTDLTELTCQ 1237
Query: 3601 RVHDLMQENFLLKSRVYDIETKIDHISNSSDEVVQILKNKKLSQNFAASSLSLPDTSIEV 3780
RVHDLMQENFLLKSRVYDIETKIDHISNSSDEVVQILKNKKLSQNFAASSLSLPDTSIEV
Sbjct: 1238 RVHDLMQENFLLKSRVYDIETKIDHISNSSDEVVQILKNKKLSQNFAASSLSLPDTSIEV 1297
Query: 3781 PKITKTLIDCHLSPVSIEDRLATRSPLLANLQRDHTLRKYDDANFQPGKLQRRARLHSSS 3960
PKITKTLIDCHLSPVSIEDRLATRSPLLANLQRDHTLRKYDDANFQPGKLQRRARLHSSS
Sbjct: 1298 PKITKTLIDCHLSPVSIEDRLATRSPLLANLQRDHTLRKYDDANFQPGKLQRRARLHSSS 1357
Query: 3961 CSISQDMKEMKTSMSSRNLKREDSGEITTSSHGGYDSDVSGPD 4089
CSISQDMKEMKTSMSSRNLKREDSGEITTSSHGGYDSDVSGPD
Sbjct: 1358 CSISQDMKEMKTSMSSRNLKREDSGEITTSSHGGYDSDVSGPD 1400
>gi|15718227|emb|CAB00861.2| C. elegans GTL-2 protein (corresponding
sequence F54D1.5) [Caenorhabditis elegans]
Length = 1363
Score = 2686 bits (6962), Expect = 0.0
Identities = 1327/1363 (97%), Positives = 1327/1363 (97%)
Frame = +1
Query: 1 MCNANTVHSISSFRSDHLSRKSTHKFLDNPNLFAIELTEKLSPPWIENTFEKRECIRFAA 180
MCNANTVHSISSFRSDHLSRKSTHKFLDNPNLFAIELTEKLSPPWIENTFEKRECIRFAA
Sbjct: 1 MCNANTVHSISSFRSDHLSRKSTHKFLDNPNLFAIELTEKLSPPWIENTFEKRECIRFAA 60
Query: 181 LPKDPERCGCGRPLSAHTPASTFFSTLPVHLLEKEQQTWTIANNTQTSTTDAFGTIVFQG 360
LPKDPERCGCGRPLSAHTPASTFFSTLPVHLLEKEQQTWTIANNTQTSTTDAFGTIVFQG
Sbjct: 61 LPKDPERCGCGRPLSAHTPASTFFSTLPVHLLEKEQQTWTIANNTQTSTTDAFGTIVFQG 120
Query: 361 GAHAHKAQYVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGMSNFELEERLGRLFRKG 540
GAHAHKAQYVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGMSNFELEERLGRLFRKG
Sbjct: 121 GAHAHKAQYVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGMSNFELEERLGRLFRKG 180
Query: 541 MLKAAQTTGAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLI 720
MLKAAQTTGAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLI
Sbjct: 181 MLKAAQTTGAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLI 240
Query: 721 RQNEHVYYDVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCN 900
RQNEHVYYDVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCN
Sbjct: 241 RQNEHVYYDVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCN 300
Query: 901 GRKVPVVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFA 1080
GRKVPVVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFA
Sbjct: 301 GRKVPVVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFA 360
Query: 1081 AEVGEKLRNLIKMVFPETDQEEMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQ 1260
AEVGEKLRNLIKMVFPETDQEEMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQ
Sbjct: 361 AEVGEKLRNLIKMVFPETDQEEMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQ 420
Query: 1261 KQNLPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLEN 1440
KQNLPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLEN
Sbjct: 421 KQNLPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLEN 480
Query: 1441 GVSMKNFLSINRLENLYNMDDINSAHSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNA 1620
GVSMKNFLSINRLENLYNMDDINSAHSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNA
Sbjct: 481 GVSMKNFLSINRLENLYNMDDINSAHSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNA 540
Query: 1621 FQLYYTSRSFKGKYDRYKRINQSSYFHRKRKIVQKELFKKKSDDQINDNEEEDFSFAYPF 1800
FQLYYTSRSFKGKYDRYKRINQSSYFHRKRKIVQKELFKKKSDDQINDNEEEDFSFAYPF
Sbjct: 541 FQLYYTSRSFKGKYDRYKRINQSSYFHRKRKIVQKELFKKKSDDQINDNEEEDFSFAYPF 600
Query: 1801 NDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEEAKRLFDN 1980
NDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEEAKRLFDN
Sbjct: 601 NDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEEAKRLFDN 660
Query: 1981 AVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPCCQIL 2160
AVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPCCQIL
Sbjct: 661 AVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPCCQIL 720
Query: 2161 LAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQLPYPRESI 2340
LAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQLPYPRESI
Sbjct: 721 LAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQLPYPRESI 780
Query: 2341 TSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKNXXXXXXXXXXXXXXFKREPQL 2520
TSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKN FKREPQL
Sbjct: 781 TSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKNSGVASVYGSASSMMFKREPQL 840
Query: 2521 NKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIYTVTLSVE 2700
NKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIYTVTLSVE
Sbjct: 841 NKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIYTVTLSVE 900
Query: 2701 HIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSWGRVLLSFS 2880
HIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSWGRVLLSFS
Sbjct: 901 HIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSWGRVLLSFS 960
Query: 2881 NVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEPNVKD 3060
NVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEPNVKD
Sbjct: 961 NVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEPNVKD 1020
Query: 3061 WHWLLVRNIFYKPYFMLYGEVYAGEIDTCGDEGIRCFPGYFIPPLLMXXXXXXXXXXXXX 3240
WHWLLVRNIFYKPYFMLYGEVYAGEIDTCGDEGIRCFPGYFIPPLLM
Sbjct: 1021 WHWLLVRNIFYKPYFMLYGEVYAGEIDTCGDEGIRCFPGYFIPPLLMVIFLLVANILLLN 1080
Query: 3241 XXXXXXXXXYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDYLYNLRR 3420
YNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDYLYNLRR
Sbjct: 1081 LLIAIFNNIYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDYLYNLRR 1140
Query: 3421 PDTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTLTRIRKLKLNTKEPLSVTDLTELTCQ 3600
PDTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTLTRIRKLKLNTKEPLSVTDLTELTCQ
Sbjct: 1141 PDTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTLTRIRKLKLNTKEPLSVTDLTELTCQ 1200
Query: 3601 RVHDLMQENFLLKSRVYDIETKIDHISNSSDEVVQILKNKKLSQNFAASSLSLPDTSIEV 3780
RVHDLMQENFLLKSRVYDIETKIDHISNSSDEVVQILKNKKLSQNFAASSLSLPDTSIEV
Sbjct: 1201 RVHDLMQENFLLKSRVYDIETKIDHISNSSDEVVQILKNKKLSQNFAASSLSLPDTSIEV 1260
Query: 3781 PKITKTLIDCHLSPVSIEDRLATRSPLLANLQRDHTLRKYDDANFQPGKLQRRARLHSSS 3960
PKITKTLIDCHLSPVSIEDRLATRSPLLANLQRDHTLRKYDDANFQPGKLQRRARLHSSS
Sbjct: 1261 PKITKTLIDCHLSPVSIEDRLATRSPLLANLQRDHTLRKYDDANFQPGKLQRRARLHSSS 1320
Query: 3961 CSISQDMKEMKTSMSSRNLKREDSGEITTSSHGGYDSDVSGPD 4089
CSISQDMKEMKTSMSSRNLKREDSGEITTSSHGGYDSDVSGPD
Sbjct: 1321 CSISQDMKEMKTSMSSRNLKREDSGEITTSSHGGYDSDVSGPD 1363
>gi|39593744|emb|CAE62037.1| Hypothetical protein CBG06053
[Caenorhabditis briggsae]
Length = 1365
Score = 2503 bits (6487), Expect = 0.0
Identities = 1222/1365 (89%), Positives = 1282/1365 (93%), Gaps = 2/1365 (0%)
Frame = +1
Query: 1 MCNANTVHSISSFRSDHLSRKSTHKFLDNPNLFAIELTEKLSPPWIENTFEKRECIRFAA 180
+CNANTVHSISSFRSDHLSRKSTHK L+NPNLFAIELTEKLSPPWIENTFEKREC+RF A
Sbjct: 1 VCNANTVHSISSFRSDHLSRKSTHKLLENPNLFAIELTEKLSPPWIENTFEKRECVRFTA 60
Query: 181 LPKDPERCGCGRPLSAHTPASTFFSTLPVHLLEKEQQTWTIANNTQTSTTDAFGTIVFQG 360
KD ERCGCGRPL+AH+ AS F TLP +++KEQ+ WTIANNTQTSTTDAFGTIVFQG
Sbjct: 61 QSKDAERCGCGRPLAAHSSASRLFYTLPYQIIDKEQEVWTIANNTQTSTTDAFGTIVFQG 120
Query: 361 GAHAHKAQYVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGMSNFELEERLGRLFRKG 540
GAHAHKAQYVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGMSNFEL+ERLGRLFRKG
Sbjct: 121 GAHAHKAQYVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGMSNFELQERLGRLFRKG 180
Query: 541 MLKAAQTTGAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLI 720
MLKAAQTTGAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLI
Sbjct: 181 MLKAAQTTGAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLI 240
Query: 721 RQNEHVYYDVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCN 900
R+NEHVYYDVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIAT+GCN
Sbjct: 241 RKNEHVYYDVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATYGCN 300
Query: 901 GRKVPVVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFA 1080
GRKVPVVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGRAAD+ISFAARYIN+DGTFA
Sbjct: 301 GRKVPVVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGRAADLISFAARYINTDGTFA 360
Query: 1081 AEVGEKLRNLIKMVFPETDQEEMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQ 1260
AEVGEKL+NLIKMVFPE+DQE M KITECVIRDDLLRIFRYG+EEEEDVDFVILSTVLQ
Sbjct: 361 AEVGEKLKNLIKMVFPESDQEGMLSKITECVIRDDLLRIFRYGEEEEEDVDFVILSTVLQ 420
Query: 1261 KQNLPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLEN 1440
KQNLPPDEQLALTLSWNRVDLAKSCLFSNGRKW SDVLEKAMNDALYWDRVDFVECLLEN
Sbjct: 421 KQNLPPDEQLALTLSWNRVDLAKSCLFSNGRKWPSDVLEKAMNDALYWDRVDFVECLLEN 480
Query: 1441 GVSMKNFLSINRLENLYNMDDINSAHSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNA 1620
GVSMKNFL+INRLENLYNMDD+NSAHSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNA
Sbjct: 481 GVSMKNFLTINRLENLYNMDDVNSAHSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNA 540
Query: 1621 FQLYYTSRSFKGKYDRYKRINQSSYFHRKRKIVQKELFKKKSDDQINDNEEEDFSFAYPF 1800
FQLYYTSRSFKGKYDRYKR+NQSSYF+RKRKIVQKELFKKKSDDQI+++ EEDFSF+YPF
Sbjct: 541 FQLYYTSRSFKGKYDRYKRLNQSSYFYRKRKIVQKELFKKKSDDQIDESSEEDFSFSYPF 600
Query: 1801 NDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEEAKRLFDN 1980
NDLLIWAVLTSRH MA+CMW+HGEDAMAKCL+AIRLYKATAKIAEDEYLDVEEAKRLFDN
Sbjct: 601 NDLLIWAVLTSRHEMAKCMWIHGEDAMAKCLVAIRLYKATAKIAEDEYLDVEEAKRLFDN 660
Query: 1981 AVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPCCQIL 2160
AVKCREDAIEL+DQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPCCQIL
Sbjct: 661 AVKCREDAIELVDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPCCQIL 720
Query: 2161 LAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQLPYPRESI 2340
LAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKH+KTARLLSEET E +PYPRESI
Sbjct: 721 LAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHAKTARLLSEETQEDIPYPRESI 780
Query: 2341 TSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKNXXXXXXXXXXXXXXFKREPQL 2520
TSTTSNRYRY KGPEEQKETLLEKG+Y KKVTIISSRKN FKR+PQL
Sbjct: 781 TSTTSNRYRYPKGPEEQKETLLEKGNYAKKVTIISSRKNSGVASVYGSASSMMFKRDPQL 840
Query: 2521 NKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIYTVTLSVE 2700
+KFE+FRAFYS+PITKFWSWCIAFLIFL TQTCILLLETSLKPSKYEWI +YTVTLSVE
Sbjct: 841 SKFEKFRAFYSAPITKFWSWCIAFLIFLITQTCILLLETSLKPSKYEWILLVYTVTLSVE 900
Query: 2701 HIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSWGRVLLSFS 2880
H+RKL+TSEGSRINEK+KVFYAKWYNIWTSAALLFFL GYGFRLVPM+RHSWGRVLLS S
Sbjct: 901 HMRKLLTSEGSRINEKIKVFYAKWYNIWTSAALLFFLFGYGFRLVPMFRHSWGRVLLSIS 960
Query: 2881 NVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEPNVKD 3060
NVLFYMK FEYLSVHPLLGPYIQMAAKMVWSMCYI VLLLVPLMAFGVNRQALTEP +KD
Sbjct: 961 NVLFYMKTFEYLSVHPLLGPYIQMAAKMVWSMCYIVVLLLVPLMAFGVNRQALTEPKIKD 1020
Query: 3061 WHWLLVRNIFYKPYFMLYGEVYAGEIDTCGDEGIRCFPGYFIPPLLMXXXXXXXXXXXXX 3240
W+WLLVRNIFYKPYFMLYGEVYAGEIDTCGDEG RCFPGYFIPPLLM
Sbjct: 1021 WNWLLVRNIFYKPYFMLYGEVYAGEIDTCGDEGTRCFPGYFIPPLLMVVFLLVANILLLN 1080
Query: 3241 XXXXXXXXXYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDYLYNLR- 3417
YNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDY++NLR
Sbjct: 1081 LLIAIFNNIYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDYIWNLRS 1140
Query: 3418 -RPDTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTLTRIRKLKLNTKEPLSVTDLTELT 3594
RPDTKRFRSEHSIK SVTEDEMKR+QDFEEDCIDTLTR R+LKL+TKEPL++TDLTELT
Sbjct: 1141 KRPDTKRFRSEHSIKWSVTEDEMKRMQDFEEDCIDTLTRTRRLKLDTKEPLNMTDLTELT 1200
Query: 3595 CQRVHDLMQENFLLKSRVYDIETKIDHISNSSDEVVQILKNKKLSQNFAASSLSLPDTSI 3774
C+RVHDLMQENFLLKSRVYDIETKIDHI+NSSDEVV ILKNKK+SQNFAAS LSLP+TSI
Sbjct: 1201 CERVHDLMQENFLLKSRVYDIETKIDHIANSSDEVVLILKNKKMSQNFAASCLSLPETSI 1260
Query: 3775 EVPKITKTLIDCHLSPVSIEDRLATRSPLLANLQRDHTLRKYDDANFQPGKLQRRARLHS 3954
EVPK+TK LID HLSPV IE+RLATRSPLLANL RDHTLRKYDDANFQ G LQRR RLHS
Sbjct: 1261 EVPKLTKPLIDYHLSPVVIEERLATRSPLLANLHRDHTLRKYDDANFQAGNLQRRTRLHS 1320
Query: 3955 SSCSISQDMKEMKTSMSSRNLKREDSGEITTSSHGGYDSDVSGPD 4089
SSCSISQDMKEM+TS SSRNLKR+DS E+T SSHGGYDSD+SGPD
Sbjct: 1321 SSCSISQDMKEMRTSASSRNLKRQDSEELTVSSHGGYDSDISGPD 1365
>gi|32565923|ref|NP_502118.2| Gon-Two Like, TRP subfamily (gtl-2)
[Caenorhabditis elegans]
gi|24412716|emb|CAC81666.1| putative TRP homologous cation channel
[Caenorhabditis elegans]
Length = 1122
Score = 2200 bits (5701), Expect = 0.0
Identities = 1086/1122 (96%), Positives = 1086/1122 (96%)
Frame = +1
Query: 724 QNEHVYYDVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCNG 903
QNEHVYYDVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCNG
Sbjct: 1 QNEHVYYDVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCNG 60
Query: 904 RKVPVVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFAA 1083
RKVPVVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFAA
Sbjct: 61 RKVPVVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFAA 120
Query: 1084 EVGEKLRNLIKMVFPETDQEEMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQK 1263
EVGEKLRNLIKMVFPETDQEEMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQK
Sbjct: 121 EVGEKLRNLIKMVFPETDQEEMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQK 180
Query: 1264 QNLPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENG 1443
QNLPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENG
Sbjct: 181 QNLPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENG 240
Query: 1444 VSMKNFLSINRLENLYNMDDINSAHSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNAF 1623
VSMKNFLSINRLENLYNMDDINSAHSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNAF
Sbjct: 241 VSMKNFLSINRLENLYNMDDINSAHSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNAF 300
Query: 1624 QLYYTSRSFKGKYDRYKRINQSSYFHRKRKIVQKELFKKKSDDQINDNEEEDFSFAYPFN 1803
QLYYTSRSFKGKYDRYKRINQSSYFHRKRKIVQKELFKKKSDDQINDNEEEDFSFAYPFN
Sbjct: 301 QLYYTSRSFKGKYDRYKRINQSSYFHRKRKIVQKELFKKKSDDQINDNEEEDFSFAYPFN 360
Query: 1804 DLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEEAKRLFDNA 1983
DLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEEAKRLFDNA
Sbjct: 361 DLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEEAKRLFDNA 420
Query: 1984 VKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPCCQILL 2163
VKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPCCQILL
Sbjct: 421 VKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPCCQILL 480
Query: 2164 AELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQLPYPRESIT 2343
AELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQLPYPRESIT
Sbjct: 481 AELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQLPYPRESIT 540
Query: 2344 STTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKNXXXXXXXXXXXXXXFKREPQLN 2523
STTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKN FKREPQLN
Sbjct: 541 STTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKNSGVASVYGSASSMMFKREPQLN 600
Query: 2524 KFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIYTVTLSVEH 2703
KFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIYTVTLSVEH
Sbjct: 601 KFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIYTVTLSVEH 660
Query: 2704 IRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSWGRVLLSFSN 2883
IRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSWGRVLLSFSN
Sbjct: 661 IRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSWGRVLLSFSN 720
Query: 2884 VLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEPNVKDW 3063
VLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEPNVKDW
Sbjct: 721 VLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEPNVKDW 780
Query: 3064 HWLLVRNIFYKPYFMLYGEVYAGEIDTCGDEGIRCFPGYFIPPLLMXXXXXXXXXXXXXX 3243
HWLLVRNIFYKPYFMLYGEVYAGEIDTCGDEGIRCFPGYFIPPLLM
Sbjct: 781 HWLLVRNIFYKPYFMLYGEVYAGEIDTCGDEGIRCFPGYFIPPLLMVIFLLVANILLLNL 840
Query: 3244 XXXXXXXXYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDYLYNLRRP 3423
YNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDYLYNLRRP
Sbjct: 841 LIAIFNNIYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDYLYNLRRP 900
Query: 3424 DTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTLTRIRKLKLNTKEPLSVTDLTELTCQR 3603
DTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTLTRIRKLKLNTKEPLSVTDLTELTCQR
Sbjct: 901 DTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTLTRIRKLKLNTKEPLSVTDLTELTCQR 960
Query: 3604 VHDLMQENFLLKSRVYDIETKIDHISNSSDEVVQILKNKKLSQNFAASSLSLPDTSIEVP 3783
VHDLMQENFLLKSRVYDIETKIDHISNSSDEVVQILKNKKLSQNFAASSLSLPDTSIEVP
Sbjct: 961 VHDLMQENFLLKSRVYDIETKIDHISNSSDEVVQILKNKKLSQNFAASSLSLPDTSIEVP 1020
Query: 3784 KITKTLIDCHLSPVSIEDRLATRSPLLANLQRDHTLRKYDDANFQPGKLQRRARLHSSSC 3963
KITKTLIDCHLSPVSIEDRLATRSPLLANLQRDHTLRKYDDANFQPGKLQRRARLHSSSC
Sbjct: 1021 KITKTLIDCHLSPVSIEDRLATRSPLLANLQRDHTLRKYDDANFQPGKLQRRARLHSSSC 1080
Query: 3964 SISQDMKEMKTSMSSRNLKREDSGEITTSSHGGYDSDVSGPD 4089
SISQDMKEMKTSMSSRNLKREDSGEITTSSHGGYDSDVSGPD
Sbjct: 1081 SISQDMKEMKTSMSSRNLKREDSGEITTSSHGGYDSDVSGPD 1122
>gi|50511021|dbj|BAD32496.1| mKIAA1616 protein [Mus musculus]
Length = 1718
Score = 759 bits (1960), Expect = 0.0
Identities = 433/1221 (35%), Positives = 690/1221 (56%), Gaps = 37/1221 (3%)
Frame = +1
Query: 133 WIENTFEKRECIRFAALPKDPERCGCGRPLSAHTPASTFFSTLPVHLLEK-------EQQ 291
WIE F KREC+ KDP RC CGR + H + S L E + +
Sbjct: 75 WIERAFYKRECVHIIPSTKDPHRCCCGRLIGQHVGLTPSISVLQNEKNESRLSRNDIQSE 134
Query: 292 TWTIANNTQTSTTDAFGTIVFQGGAHAHKAQYVRLSYDSEPLDVMYLMEKVWGLEAPRLV 471
W+I+ +TQ S TDAFGTI FQGG H++KA YVR+S+D++P +++LM K W LE P+L+
Sbjct: 135 KWSISKHTQLSPTDAFGTIEFQGGGHSNKAMYVRVSFDTKPDLLLHLMTKEWQLELPKLL 194
Query: 472 ITVHGGMSNFELEERLGRLFRKGMLKAAQTTGAWIITSGLDSGVVRHVAKALDEAGISAR 651
I+VHGG+ NFEL+ +L ++F KG++KAA TTGAWI T G+++GV+RHV AL + +++
Sbjct: 195 ISVHGGLQNFELQPKLKQVFGKGLIKAAMTTGAWIFTGGVNTGVIRHVGDALKDH--ASK 252
Query: 652 MRSQIVTIGIAPWGVIKRKERLIRQNEHVYYDVHSLSVNANVGILNDRHSYFLLADNGTV 831
R +I TIGIAPWG+++ +E LI ++ Y S + + + +LN HS+F+LADNGT
Sbjct: 253 SRGKICTIGIAPWGIVENQEDLIGRDVVRPYQTMS-NPMSKLTVLNSMHSHFILADNGTT 311
Query: 832 GRFGADLHLRQNLENHIATFGCN---GRKVPVVCTLLEGGISSINAIHDYVTMKPDIPAI 1002
G++GA++ LR+ LE HI+ N G+ VPVV ++EGG + I+ + +Y+ P +P +
Sbjct: 312 GKYGAEVKLRRQLEKHISLQKINTRIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVV 371
Query: 1003 VCDGSGRAADIISFAARYINSDGTFAAEVGEKLRNLIKMVF--PETDQEEMFRKITECVI 1176
VCDGSGRA+DI++F +Y G + ++L I+ F T + +F + EC+
Sbjct: 372 VCDGSGRASDILAFGHKYSEEGGLINESLRDQLLVTIQKTFTYTRTQAQHLFIILMECMK 431
Query: 1177 RDDLLRIFRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWNRVDLAKSCLFSNGRK 1356
+ +L+ +FR G E +D+D IL+ +L+ N +QL+L L+WNRVD+A+S +F G++
Sbjct: 432 KKELITVFRMGSEGHQDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQ 491
Query: 1357 WSSDVLEKAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLYNMDDINS---AHSVR 1527
W LE+AM DAL DRVDFV+ L+ENGVSM FL+I+RLE LYN S H VR
Sbjct: 492 WPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVR 551
Query: 1528 NWMENFDSMDPHTYLTIPMIGQVVEKLMGNAFQLYYTSRSFKGKYDRY---KRINQSSYF 1698
+ + ++ P +++ IG V+E LMG A++ YT + F+ Y KR
Sbjct: 552 DVKKG--NLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLL 609
Query: 1699 HRKRKIV----QKELFKKKSDDQINDNEEEDFSFAYPFNDLLIWAVLTSRHGMAECMWVH 1866
+ I +K K++ + I+ ++ E F +PF++L++WAVL R MA W H
Sbjct: 610 GMEDDIPLRRGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQH 669
Query: 1867 GEDAMAKCLLAIRLYKATAKIAEDEYLDVEEAKRLFDNAVKCREDAIELLDQCYRADHDR 2046
GE+AMAK L+A +L KA A A + + + ++ L N+ + A+ELLDQ Y+ D
Sbjct: 670 GEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQL 729
Query: 2047 TLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPCCQILLAELWHGSLKVRSGSNVRVLTA 2226
++LL EL +W N CL LAV A + F+AH C Q+LL ++W G L++R S ++V+
Sbjct: 730 AMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILG 789
Query: 2227 LICPPAILFMAYKPKHSKTARLLSEETPEQLPYPRESITSTTSNRYRYSKGPEEQKETLL 2406
++ PP+IL + +K K + +PY ++ + K PEE ++
Sbjct: 790 ILLPPSILSLEFKNK-------------DDMPYMTQA-----QEIHLQEKEPEEPEKPTK 831
Query: 2407 EKGSYTKKVTIISSRKNXXXXXXXXXXXXXXFKREPQLNKFERFRAFYSSPITKFWSWCI 2586
EK ++T + R N R + + + FY++PI KFW + +
Sbjct: 832 EKDEEDMELTAMLGRSNGESSRKKDEEEVQSRHRLIPVGR--KIYEFYNAPIVKFWFYTL 889
Query: 2587 AFLIFLTTQTCILLLETSLKPSKYEWITFIYTVTLSVEHIRKLMTSEGSRINEKVKVFYA 2766
A++ +L I+L++ PS EWI Y TL +E +R+++ SE ++ +KVKV+
Sbjct: 890 AYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQ 949
Query: 2767 KWYNIWTSAALLFFLVGYGFRLVPMYRHSWGRVLLSFSNVLFYMKIFEYLSVHPLLGPYI 2946
+++N+ A+L F VG RL S GRV+ + + +Y+++ + V+ LGPY+
Sbjct: 950 EYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYV 1009
Query: 2947 QMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEPNVKDWHWLLVRNIFYKPYFMLYGEVY 3126
M KM+ M Y +++LV LM+FGV RQA+ PN ++ W L +NIFY PY+M+YGEV+
Sbjct: 1010 MMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPN-EEPSWKLAKNIFYMPYWMIYGEVF 1068
Query: 3127 AGEID-TCGDEGIR----------CFPGYFIPPLLMXXXXXXXXXXXXXXXXXXXXXXYN 3273
A +ID CG R C G +I P +M +
Sbjct: 1069 ADQIDPPCGQNETREDGKTIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFF 1128
Query: 3274 DSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDYL-YNLRRPDTKRFRSEH 3450
+ S ++W FQRYQ +M +H+ P LPPP IF+H+ ++ R+ ++ + ++
Sbjct: 1129 EVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHVCCRWRKHESDQDERDY 1188
Query: 3451 SIKLSVTEDEMKRIQDFEEDCIDTLTRIRKLKLNTK--EPLSVT-DLTELTCQRVHDLMQ 3621
+KL +T+DE+K++ DFEE CI+ R + + N+ E + VT + E R+ ++ +
Sbjct: 1189 GLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNE 1248
Query: 3622 ENFLLKSRVYDIETKIDHISN 3684
+K+ + ++ ++ + +
Sbjct: 1249 REHSMKASLQTVDIRLAQLED 1269
>gi|30141363|emb|CAD43605.1| long transient receptor potential channel
3 [Homo sapiens]
Length = 1325
Score = 758 bits (1958), Expect = 0.0
Identities = 436/1226 (35%), Positives = 688/1226 (55%), Gaps = 37/1226 (3%)
Frame = +1
Query: 118 KLSPPWIENTFEKRECIRFAALPKDPERCGCGRPLSAHTPASTFFSTLPVHLLEK----- 282
K WIE F KREC+ KDP RC CGR + H + S L E
Sbjct: 59 KAQKSWIERAFYKRECVHIIPSTKDPHRCCCGRLIGQHVGLTPSISVLQNEKNESRLSRN 118
Query: 283 --EQQTWTIANNTQTSTTDAFGTIVFQGGAHAHKAQYVRLSYDSEPLDVMYLMEKVWGLE 456
+ + W+I+ +TQ S TDAFGTI FQGG H++KA YVR+S+D++P +++LM K W LE
Sbjct: 119 DIQSEKWSISKHTQLSPTDAFGTIEFQGGGHSNKAMYVRVSFDTKPDLLLHLMTKEWQLE 178
Query: 457 APRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTTGAWIITSGLDSGVVRHVAKALDEA 636
P+L+I+VHGG+ NFEL+ +L ++F KG++KAA TTGAWI T G+++GV+RHV AL +
Sbjct: 179 LPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTTGAWIFTGGVNTGVIRHVGDALKDH 238
Query: 637 GISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYYDVHSLSVNANVGILNDRHSYFLLA 816
+++ R +I TIGIAPWG+++ +E LI ++ Y S + + + +LN HS+F+LA
Sbjct: 239 --ASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQTMS-NPMSKLTVLNSMHSHFILA 295
Query: 817 DNGTVGRFGADLHLRQNLENHIATFGCN---GRKVPVVCTLLEGGISSINAIHDYVTMKP 987
DNGT G++GA++ LR+ LE HI+ N G+ VPVV ++EGG + I+ + +Y+ P
Sbjct: 296 DNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVVALIVEGGPNVISIVLEYLRDTP 355
Query: 988 DIPAIVCDGSGRAADIISFAARYINSDGTFAAEVGEKLRNLIKMVF--PETDQEEMFRKI 1161
+P +VCDGSGRA+DI++F +Y G + ++L I+ F T + +F +
Sbjct: 356 PVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQLLVTIQKTFTYTRTQAQHLFIIL 415
Query: 1162 TECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWNRVDLAKSCLF 1341
EC+ + +L+ +FR G E +D+D IL+ +L+ N +QL+L L+WNRVD+A+S +F
Sbjct: 416 MECMKKKELITVFRMGSEGHQDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIF 475
Query: 1342 SNGRKWSSDVLEKAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLYNMDDINS--- 1512
G++W LE+AM DAL DRVDFV+ L+ENGVSM FL+I+RLE LYN S
Sbjct: 476 IYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTL 535
Query: 1513 AHSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNAFQLYYTSRSFKGKYDRY---KRIN 1683
H VR+ + ++ P +++ IG V+E LMG A++ YT + F+ Y KR
Sbjct: 536 YHLVRDVKKG--NLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPK 593
Query: 1684 QSSYFHRKRKIV----QKELFKKKSDDQINDNEEEDFSFAYPFNDLLIWAVLTSRHGMAE 1851
+ I +K K++ + I+ ++ E F +PF++L++WAVL R MA
Sbjct: 594 ALKLLGMEDDIPLRRGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMAL 653
Query: 1852 CMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEEAKRLFDNAVKCREDAIELLDQCYR 2031
W HGE+AMAK L+A +L KA A A + + + ++ L N+ + A+ELLDQ Y+
Sbjct: 654 FFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYK 713
Query: 2032 ADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPCCQILLAELWHGSLKVRSGSNV 2211
D ++LL EL +W N CL LAV A + F+AH C Q+LL ++W G L++R S +
Sbjct: 714 QDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGL 773
Query: 2212 RVLTALICPPAILFMAYKPKHSKTARLLSEETPEQLPYPRESITSTTSNRYRYSKGPEEQ 2391
+V+ ++ PP+IL + +K K + +PY S + K EE
Sbjct: 774 KVILGILLPPSILSLEFKNK-------------DDMPY-----MSQAQEIHLQEKEAEEP 815
Query: 2392 KETLLEKGSYTKKVTIISSRKNXXXXXXXXXXXXXXFKREPQLNKFERFRAFYSSPITKF 2571
++ EK ++T + R N R L + + FY++PI KF
Sbjct: 816 EKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGR--KIYEFYNAPIVKF 873
Query: 2572 WSWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIYTVTLSVEHIRKLMTSEGSRINEKV 2751
W + +A++ +L I+L++ PS EWI Y TL +E +R+++ SE ++ +KV
Sbjct: 874 WFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKV 933
Query: 2752 KVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSWGRVLLSFSNVLFYMKIFEYLSVHPL 2931
KV+ +++N+ A+L F VG RL S GRV+ + + +Y+++ + V+
Sbjct: 934 KVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKY 993
Query: 2932 LGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEPNVKDWHWLLVRNIFYKPYFML 3111
LGPY+ M KM+ M Y +++LV LM+FGV RQA+ PN ++ W L +NIFY PY+M+
Sbjct: 994 LGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPN-EEPSWKLAKNIFYMPYWMI 1052
Query: 3112 YGEVYAGEID-TCGDEGIR----------CFPGYFIPPLLMXXXXXXXXXXXXXXXXXXX 3258
YGEV+A +ID CG R C G +I P +M
Sbjct: 1053 YGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVF 1112
Query: 3259 XXXYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDYL-YNLRRPDTKR 3435
+ + S ++W FQRYQ +M +H+ P LPPP IF+H+ +L R+ ++
Sbjct: 1113 NNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDP 1172
Query: 3436 FRSEHSIKLSVTEDEMKRIQDFEEDCIDTLTRIRKLKLNTK--EPLSVT-DLTELTCQRV 3606
++ +KL +T+DE+K++ DFEE CI+ R + + N+ E + VT + E R+
Sbjct: 1173 DERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRL 1232
Query: 3607 HDLMQENFLLKSRVYDIETKIDHISN 3684
++ + +K+ + ++ ++ + +
Sbjct: 1233 EEVNEREHSMKASLQTVDIRLAQLED 1258
>gi|48104806|ref|XP_395849.1| similar to ENSANGP00000005757 [Apis
mellifera]
Length = 1607
Score = 730 bits (1885), Expect = 0.0
Identities = 468/1319 (35%), Positives = 707/1319 (53%), Gaps = 67/1319 (5%)
Frame = +1
Query: 277 EKEQQTWTIANNTQTSTTDAFGTIVFQGGAHAHKAQYVRLSYDSEPLDVMYLMEKVWGLE 456
EK+++ W+ A NT+ TDA+GTI FQGG H KAQYVRL+YD+ P +++L+ + W L
Sbjct: 33 EKDREQWSPAKNTRPFPTDAYGTIEFQGGPHPTKAQYVRLAYDTRPEPIVHLLCREWNLG 92
Query: 457 APRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTTGAWIITSGLDSGVVRHVAKALDEA 636
P+L+ITVHGG SNFEL+ L ++ RKG+LKAA+TTGAWI T G ++GV R V AL
Sbjct: 93 LPKLLITVHGGRSNFELQPTLKKVLRKGLLKAAKTTGAWIFTGGTNTGVTRQVGDALLLE 152
Query: 637 GISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYYDVHSLSVNANVGILNDRHSYFLLA 816
++ + ++V+IGIAPWG++ + L+ + V YD S S + +LN+RH+YFLL
Sbjct: 153 --RSQRQGRVVSIGIAPWGILDKSHELVGRGGEVSYDCLS-SPWSKYAVLNNRHAYFLLV 209
Query: 817 DNGTVGRFGADLHLRQNLENHIATFGCNG---RKVPVVCTLLEGGISSINAIHDYVTMKP 987
DNGT GR+GA++ LR+ LE +I+ +PVV ++EGG ++I ++ +YVT P
Sbjct: 210 DNGTGGRYGAEIVLRRRLEKYISNLKLQPYTHSSIPVVALVIEGGTNTIRSVLEYVTDVP 269
Query: 988 DIPAIVCDGSGRAADIISFAARYINS-DGTFAAEVG------EKLRNLIKMVFPETDQE- 1143
+P +VCDGSGRAAD+I+F +Y + DG G E L + IK F + ++
Sbjct: 270 PVPVVVCDGSGRAADLIAFMHKYASEGDGENGDIEGPLESMREHLLDTIKRTFKVSAEQA 329
Query: 1144 -EMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWNRVD 1320
+++ ++ +C + L+ +FR QE +++D IL+ + + + L P EQL+L+L WNRVD
Sbjct: 330 SQLYSELLQCTRKKHLITVFRISQERPQELDQTILTALFKSKQLSPAEQLSLSLIWNRVD 389
Query: 1321 LAKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLYNMD 1500
+A+ +F G+ W LE+AM AL DR+DFV+ LLENGVSM+ FLSI RLE LYN
Sbjct: 390 IARCEIFVYGQNWPPGALEQAMMQALQHDRIDFVKLLLENGVSMRKFLSIPRLEELYNTK 449
Query: 1501 DINSAHSVRNWMENFDSMDPHTYL-TIPMIGQVVEKLMGNAFQLYYTSRSFKGKYDRYKR 1677
+ ++++ + + P Y+ T+ IG V+ KLMG A++ YT R F+
Sbjct: 450 E-GPSNTLGYILRDVRPNIPRGYMYTLHDIGLVINKLMGGAYRSQYTRRRFRSGSK---- 504
Query: 1678 INQSSYFHRKRKIVQKELFKKKSDDQINDNEEEDFSFAYPFNDLLIWAVLTSRHGMAECM 1857
Q L + + N + F YPFN+LLIWAVLT R MA M
Sbjct: 505 --------------QDSLTMSLLAETLPANRDTPL-FDYPFNELLIWAVLTKRQQMALLM 549
Query: 1858 WVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEEAKRL------FDNAVKCREDAIELLD 2019
W HGE+A+AK L+A++LYKA A A ++ L+ E L F+N + A+ELLD
Sbjct: 550 WQHGEEALAKALVALKLYKAMAHEAAEDDLETEVYDELRSYGKEFEN-IGTNICALELLD 608
Query: 2020 QCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPCCQILLAELWHGSLKVRS 2199
CYR D D+T +LL EL +W CLSLAV AN + LAHPC QI+LA+LW G L+ R
Sbjct: 609 FCYRQDDDQTKQLLTSELQNWSGQTCLSLAVTANHRPLLAHPCSQIILADLWMGGLRTRK 668
Query: 2200 GSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQLPYPRESITSTTSNRYRYSKG 2379
+N++V+ LICP I+ + +K S+ L +T E+ E + + + G
Sbjct: 669 NTNLKVVLGLICPFYIICLEFK---SREELQLMPQTQEEHLIALEDEKEDSDSEHGIPTG 725
Query: 2380 PEEQKE---------------------------TLLEKGSYTKKVTIISSRKNXXXXXXX 2478
P+ +K T++++ + +++ +
Sbjct: 726 PDVEKRQRRSLSVRNKSSSQQGAKALISNEHTTTIVKETIVQENGKVLTDNDDGIHRAYG 785
Query: 2479 XXXXXXXFKREPQLNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKY 2658
K L ++ FY++PITKFW+ IA++IFL + +L+ PS
Sbjct: 786 IHSDYYDIKNSRPLRLRKKLYEFYTAPITKFWANAIAYMIFLVLFSYSILIHMDDHPSLA 845
Query: 2659 EWITFIYTVTLSVEHIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVP 2838
E Y TL E +R++ TSE + ++ K V+ +N +AA++FF +G RL
Sbjct: 846 EIYAIAYICTLGCEKVREIATSEPATLSHKFSVWAWNMWNPCDAAAIIFFQIGLALRL-- 903
Query: 2839 MYRHSW---GRVLLSFSNVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPL 3009
RHS GRV+ + +Y++I L V+ GP + M KMV +M Y VLL+V L
Sbjct: 904 --RHSTLDVGRVIYCVDCIYWYLRILNILGVNKYFGPLVTMMGKMVKNMTYFVVLLIVVL 961
Query: 3010 MAFGVNRQALTEPNVKDWHWLLVRNIFYKPYFMLYGEVYAGEID-TCGDEG--IRCFPGY 3180
++FGV RQA+ PN + + ++R+IF +PYFMLYGEVYA ID CGDE I C PG
Sbjct: 962 LSFGVTRQAILNPNAEP-KFRIIRDIFMEPYFMLYGEVYADNIDPDCGDEPGMIPCLPGR 1020
Query: 3181 FIPPLLMXXXXXXXXXXXXXXXXXXXXXXYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPP 3360
+I P +M +N+ + ++W+FQR+ +MEY P LPP
Sbjct: 1021 WITPAVMSIYLLIANILLINLLIAVFNNIFNEVNAVAHQVWMFQRFTVVMEYEQKPVLPP 1080
Query: 3361 PFSIFAHVYHFIDYL--YNLRRPDTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTLTRI 3534
P + H+Y + YL Y + + ++ +KL + D+M+R+ DFEEDC++ R
Sbjct: 1081 PLIVVCHIYLVVKYLLRYITQGKASSGETYDNGLKLFLEADDMERLYDFEEDCVEGYFRE 1140
Query: 3535 RKLKLNTKEPLSVTDLTELTCQRVHDLMQENFLLKSRVYDIETKIDHISNSSDEVVQ--I 3708
++LKL +S + ++T +RV + + S++ DI+ K ++ N+S + V+ I
Sbjct: 1141 QELKLQ----MSTEERVKITTERVEN-------MHSKIEDIDKK-ENTQNASLQAVEFRI 1188
Query: 3709 LKNKKLS-QNFAASSLSLPDTSIEVPKITKTLIDCHLSPVSIEDRLATRSPLLANLQRDH 3885
K ++L+ Q A + + +P I LS IE R S +R
Sbjct: 1189 RKLEELNEQTLAHLGVIHRFMATHMPNIE------GLSNFDIEGRQRRVS------ERSE 1236
Query: 3886 TLRKYDDANFQPGKLQRRARLHSSSC---------SISQD-MKEMKTSMSSRNLKREDS 4032
L + D P +R RL S S+ D MK +T MS NL R +S
Sbjct: 1237 VLSETDSHTQLPTITAKRKRLVRSMTDATFLNLGPSLDDDIMKHSETIMSRENLSRNES 1295
>gi|31199943|ref|XP_308919.1| ENSANGP00000005757 [Anopheles gambiae]
gi|30178864|gb|EAA04234.2| ENSANGP00000005757 [Anopheles gambiae str.
PEST]
Length = 1070
Score = 730 bits (1884), Expect = 0.0
Identities = 423/1089 (38%), Positives = 617/1089 (55%), Gaps = 21/1089 (1%)
Frame = +1
Query: 199 RCGCGRPLSAHTPASTFFSTLPVHLLEKEQQTWTIANNTQTSTTDAFGTIVFQGGAHAHK 378
RC CG+ H + + + +P +W + NT+ TDA+GTI FQGGAH K
Sbjct: 1 RCCCGQERRTHQVLAGYEAGVPT-------DSWQASKNTRAQPTDAYGTIEFQGGAHPTK 53
Query: 379 AQYVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQ 558
AQYVRLSYD+ P ++ L + W LE P+L+ITV GG +NFEL+ +L ++ RKG+LKAA+
Sbjct: 54 AQYVRLSYDTRPELLVQLFTREWNLELPKLLITVQGGKANFELQPKLKKVLRKGLLKAAK 113
Query: 559 TTGAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHV 738
TTGAWI T G ++GV + V AL G + ++V+IGIAPWG+++R L+ N V
Sbjct: 114 TTGAWIFTGGTNTGVTKQVGDALLLEG--QQRSGRVVSIGIAPWGIVERNHELLGHNRDV 171
Query: 739 YYDVHSLSV-NANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCNG---R 906
HS+S + + +LN+RH+YFLL DNGT GR+GA+L LR+ LE +I+
Sbjct: 172 --PCHSISSPRSKLAVLNNRHAYFLLVDNGTQGRYGAELILRRKLEKYISNQKLQPFTHS 229
Query: 907 KVPVVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGRAADIISFAARYINSDG--TFA 1080
PVVC ++EGG ++I A+ +YVT P +P +VCDGSGRAAD+I+F +Y +G T
Sbjct: 230 STPVVCLVIEGGTNTIRAVLEYVTDNPPVPVVVCDGSGRAADLIAFVHKYATDNGEQTVL 289
Query: 1081 AEVGEKLRNLIKMVFP-ETDQ-EEMFRKITECVIRDDLLRIFRYGQEEE---EDVDFVIL 1245
+ + + +I+ F T+Q E++F+++ +C +L+ +FR E +++D IL
Sbjct: 290 ESMHDYVLGIIQKTFEVSTEQAEQLFQELLQCTKNKNLITVFRIQDRPEGNTQELDQTIL 349
Query: 1246 STVLQKQNLPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVE 1425
+ + + Q+L P EQL+L L+WNRVD+A+S +F G++W L++AM AL DR+DFV+
Sbjct: 350 TALFKSQHLSPPEQLSLALTWNRVDIARSEIFVYGQEWPHGALDEAMMQALEHDRIDFVK 409
Query: 1426 CLLENGVSMKNFLSINRLENLYNMDDINSAHSVRNWMENFDSMDPHTYL-TIPMIGQVVE 1602
LLENGVSM+ FL+I RLE LYN A+++ + + P Y+ T+ IG V+
Sbjct: 410 LLLENGVSMRKFLTIPRLEELYNTKH-GPANTLGYILRDVRPHIPKGYVYTLHDIGLVIN 468
Query: 1603 KLMGNAFQLYYTSRSFKGKYDRYKRINQSSYFHRKRKIVQKE--LFKKKSDDQINDNEEE 1776
KLMG A++ YYT R F+ Y K +N HRK Q+ + + +
Sbjct: 469 KLMGGAYRSYYTRRKFRPIYA--KVMNSYVNTHRKPSTFQRSAGINSMSLVTGLLPVTTD 526
Query: 1777 DFSFAYPFNDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVE 1956
F PFN+LLIWAVLT R MA MW HGE+A+AK L+A +LYKA A A D+ LD E
Sbjct: 527 MALFELPFNELLIWAVLTKRQQMALLMWTHGEEALAKSLVACKLYKAMAHEAADDDLDTE 586
Query: 1957 EAKRLFDNAVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFL 2136
+ L A + ++LLD CYR D +R RLL EL W + +CLSLAV AN + L
Sbjct: 587 IYEELRSYAKEFESKGLKLLDFCYRQDAERAQRLLTCELQSWSSQSCLSLAVAANHRAIL 646
Query: 2137 AHPCCQILLAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQ 2316
AHPC QI+LA+LW G L+ R +N++V+ L+CPP + + +K S+E +Q
Sbjct: 647 AHPCSQIILADLWMGGLRTRKNTNLKVICGLLCPPFVRKLDFK----------SKEELQQ 696
Query: 2317 LPYPRESITSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKNXXXXXXXXXXXXX 2496
+P E Y + E LL K + + K
Sbjct: 697 MPQTEEEHLENQYLDYEDRDKKDTDAEALLSDTYSMKDTKVQENGKVSLTDSENTQYKDY 756
Query: 2497 XF----KREPQLNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEW 2664
F +++ L ++F FY++PITKFW+ +A++ FL T +L+ PS EW
Sbjct: 757 LFDSDGRQQRPLKLKKKFYEFYTAPITKFWADSMAYVFFLVLFTYTVLVRMEESPSWQEW 816
Query: 2665 ITFIYTVTLSVEHIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMY 2844
Y TL E IR++++SE I K V+ +N +AA++FFL+G G RL P Y
Sbjct: 817 YAISYIATLGCEKIREIVSSEPVAIPHKFSVWAWNMWNPCDAAAIIFFLIGLGLRLRP-Y 875
Query: 2845 RHSWGRVLLSFSNVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGV 3024
GRV+ ++ +Y++I L V+ LGP + M KMV +M Y VLLLV LM+FGV
Sbjct: 876 TMDIGRVIYCVDSIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFVVLLLVVLMSFGV 935
Query: 3025 NRQALTEPNVKDWHWLLVRNIFYKPYFMLYGEVYAGEID-TCGDEGIR--CFPGYFIPPL 3195
+RQA+ PN D W LVR+++Y+PYFMLYGEV+A +ID CG++ + C G+++ P+
Sbjct: 936 SRQAILFPN-NDASWRLVRDVYYQPYFMLYGEVFADDIDPPCGEDPSQPPCVTGHWVTPI 994
Query: 3196 LMXXXXXXXXXXXXXXXXXXXXXXYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIF 3375
M + + S ++W+FQR+ +MEY P LPPP
Sbjct: 995 AMSMYLLIANILLINLLIAVFNNIFIEVNAVSHQVWMFQRFTVVMEYQQKPVLPPPLIAL 1054
Query: 3376 AHVYHFIDY 3402
H Y + Y
Sbjct: 1055 CHFYSLLRY 1063
>gi|47214189|emb|CAG00817.1| unnamed protein product [Tetraodon
nigroviridis]
Length = 1342
Score = 721 bits (1861), Expect = 0.0
Identities = 438/1252 (34%), Positives = 672/1252 (52%), Gaps = 119/1252 (9%)
Frame = +1
Query: 133 WIENTFEKRECIRFAALPKDPERCGCGRPLSAHTPASTFFSTLPVHLLEKEQQT---WTI 303
WIE TF+KRECI+ + KD RCGCG+ + H P T L++ T W++
Sbjct: 6 WIEKTFQKRECIQVLS-SKDSSRCGCGQLIVQHHPLQTGNKDEESPLVDVTVPTTERWSV 64
Query: 304 ANNTQTSTTDAFGTIVFQGGAHAHKAQYVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVH 483
+TQ S TDA+G I FQGG +KA Y+R+SYDS+P +++LM K W LE P L+I+VH
Sbjct: 65 LKHTQASPTDAYGLIEFQGGGQVNKATYIRVSYDSKPDSLLHLMVKEWQLELPTLLISVH 124
Query: 484 GGMSNFELEERLGRLFRKGMLKAAQTTGAWIITSGLDSGVVRHVAKALDEAGISARMRSQ 663
GG+ NFEL +L ++F KG++KAA TTGAWI T G+D+GV+RHV AL + S++ R +
Sbjct: 125 GGLQNFELPPKLKQVFGKGLIKAALTTGAWIFTGGVDTGVIRHVGDALKDH--SSKSRGK 182
Query: 664 IVTIGIAPWGVIKRKERLIRQNEHVYYDVHSLSVNANVGILNDRHSYFLLADNGTVGRFG 843
+ IG+APWG+++ KE L+ ++ Y + S + + + LN HS+F+LADNGT G++G
Sbjct: 183 VCAIGMAPWGIVENKEDLVGRDVTRPYQMMS-NPFSKLSALNSSHSHFILADNGTTGKYG 241
Query: 844 ADLHLRQNLENHIATFGCNGRKVPVVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGR 1023
A++ LR+ LE HIA N R VPVVC +LEGG + I+ + + + +P +P ++CDGSGR
Sbjct: 242 AEVRLRRQLEKHIALQKINTR-VPVVCLILEGGPNVISIMLESLREEPPVPVVICDGSGR 300
Query: 1024 AADIISFAARYINSDGTFAAEVGEKLRNLIKMVF--PETDQEEMFRKITECVIRDDLLRI 1197
AADIISFA +Y DG + + ++L I+ F + + + +TEC+ + L+ +
Sbjct: 301 AADIISFAHKYCEEDGMLSDNIKDQLLVTIQKTFNYSRSQAQHILLMVTECMKKKPLITV 360
Query: 1198 FRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWNRVDLAKSCLF------------ 1341
FR G E ++D++ IL+ +L+ N +QL+L L+WNRVD+A+S +F
Sbjct: 361 FRMGLEGQQDIEMSILTALLKGTNASASDQLSLALAWNRVDIARSQIFVFGLHAPPVRTL 420
Query: 1342 --------------------------SNGRKWSSDV-----------------LEKAMND 1392
S G K ++ LE+AM D
Sbjct: 421 LTDRPKSPKVQQAAAGGGKGKTRGKKSKGGKSKAEAPEETDPRKLELLSWVNSLEQAMMD 480
Query: 1393 ALYWDRVDFVECLLENGVSMKNFLSINRLENLYN--MDDINSAHSVRN-------WMENF 1545
AL DRVDFV+ L+ENGV+M +FL+I RLE LYN + +N+ H V W F
Sbjct: 481 ALVLDRVDFVKLLIENGVNMNHFLTIPRLEELYNTKLGPVNTLHFVVRDVKKVCCWFMLF 540
Query: 1546 ----------------DSMDPHTYLTIPMIGQVVEKLMGNAFQLYYTSRSFKGKYDRYKR 1677
++ P +T+ IG V+E LMG A++ YT +SF+ Y+
Sbjct: 541 RCFRLHMRLRRSCVFQGNLPPDYQITLIDIGLVLEVLMGGAYRCKYTRKSFRTLYNNLYG 600
Query: 1678 INQSSYF--------HRKRKIVQKELFKKKSDDQINDNEEEDFSFAYPFNDLLIWAVLTS 1833
+ + + K K+ KK+ + I+ ++ E F YPF++L++WAVLT
Sbjct: 601 LKRPKALKLLGMEDDEPRSKGKGKKNKKKEEEVDIDVDDPEVSRFQYPFHELMVWAVLTK 660
Query: 1834 RHGMAECMWVHGEDAMAKCLLAIRLYKATA------KIAEDEYLDVEEAKRLFDNAVKCR 1995
R MA +W HGE+AMAK L+A +LYKA A ++ +D + D+E R F
Sbjct: 661 RQKMALFLWQHGEEAMAKALVACKLYKAMAHESSQSELVDDIFQDLESNSREFGQL---- 716
Query: 1996 EDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPCCQILLAELW 2175
A ELLDQ Y+ D ++LL EL +W N+ CL LAV A + F+AH C Q+LL ++W
Sbjct: 717 --AYELLDQSYKRDEQVAMKLLTYELKNWSNSTCLKLAVAAKHRDFIAHTCSQMLLTDMW 774
Query: 2176 HGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQLPYPRESITSTTS 2355
G L++ ++++V+ +I PPAIL + ++ L EE P E+ S T
Sbjct: 775 MGCLRMGKSNSLKVILGIIFPPAILLLDFR---------LGEEASN----PSENQESGTK 821
Query: 2356 NR-YRYSKGPEEQKETLLEKGSYTKKVTIISSRKNXXXXXXXXXXXXXXFKREPQLNK-F 2529
+ + SK + +KG ++ +K+ +R P + K F
Sbjct: 822 DEDNKSSKDVASNVDVTSKKGDEEEE-----QKKSK--------------RRTPVVKKIF 862
Query: 2530 ERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIYTVTLSVEHIR 2709
E FY++P TKFW I++L++L I+L++ PS EW Y +TL +E +R
Sbjct: 863 E----FYNAPFTKFWFNTISYLVYLMLYNYIILVKMERWPSLQEWTVIAYIITLGLEKVR 918
Query: 2710 KLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSWGRVLLSFSNVL 2889
+++ SE ++ +K+ V+ ++NI A+ FL+G RL +GRV+ +
Sbjct: 919 QILMSEPGKLKQKINVWLEDYWNITDLVAISVFLLGLLLRLQNEPSMGYGRVIYCVDIIF 978
Query: 2890 FYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEPNVKDWHW 3069
+Y+++ + V+ LGPY+ M KM+ M Y V++LV LM+FGV RQA+ P+ ++ W
Sbjct: 979 WYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMSFGVARQAILHPD-EEPTW 1037
Query: 3070 LLVRNIFYKPYFMLYGEVYAGEID--------TCGD-----EGIR---CFPGYFIPPLLM 3201
L RNIFY PY+M+YGEV+A ID CGD +G + C PG ++ P +M
Sbjct: 1038 RLARNIFYMPYWMIYGEVFADSIDLYAMEINPPCGDNMYDEDGKKLPPCIPGAWLTPAIM 1097
Query: 3202 XXXXXXXXXXXXXXXXXXXXXXYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAH 3381
+ + S ++W FQRYQ +M +HD P LPPP IF+H
Sbjct: 1098 ACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHDRPILPPPLIIFSH 1157
Query: 3382 VYHFIDYLY--NLRRPDTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTLTR 3531
++ + L RPD +R E ++L + +E+K + +FEE C++ R
Sbjct: 1158 IFILLRRLLCPCRHRPDGERDHRERGLQLVLNPEELKSLHEFEEQCVEEYFR 1209
>gi|19922314|ref|NP_611026.1| CG30078-PA [Drosophila melanogaster]
gi|17861698|gb|AAL39326.1| GH22805p [Drosophila melanogaster]
gi|21627148|gb|AAF58153.2| CG30078-PA [Drosophila melanogaster]
Length = 1131
Score = 715 bits (1845), Expect = 0.0
Identities = 422/1122 (37%), Positives = 624/1122 (55%), Gaps = 32/1122 (2%)
Frame = +1
Query: 133 WIENTFEKRECIRFAALPKDPERCGCGRPLSAHTPASTFFSTLPVHLLEKEQQTWTIANN 312
WIE F+KRECI+F PKD +C CG+ H S P L W +
Sbjct: 15 WIETNFQKRECIKFIPCPKDDTKCCCGQAQITHQTIPGIESGSPGDL-------WLPTKH 67
Query: 313 TQTSTTDAFGTIVFQGGAHAHKAQYVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGM 492
T+ TDA+GTI FQGGAH KAQYVRLS+D+ P ++ L K W LE P+L+ITV GG
Sbjct: 68 TRPQPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEWNLELPKLLITVQGGK 127
Query: 493 SNFELEERLGRLFRKGMLKAAQTTGAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVT 672
+NF+L+ +L + RKG+LKAA+TTGAWI T G ++GV + V AL G + ++V+
Sbjct: 128 ANFDLQAKLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDALLLEG--QQRTGRVVS 185
Query: 673 IGIAPWGVIKRKERLIRQNEHVYYDVHSLSV-NANVGILNDRHSYFLLADNGTVGRFGAD 849
IGIAPWG+++R L+ N V HS+S + + +LN+RH+YFLL DNGT ++GA+
Sbjct: 186 IGIAPWGIVERNHELLGHNREV--PCHSISSPRSKLAVLNNRHAYFLLVDNGTQAKYGAE 243
Query: 850 LHLRQNLENHIATFGCNG---RKVPVVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSG 1020
L LR+ LE I+ + PVVC ++EGG ++I A+ +YVT P +P +VCDGSG
Sbjct: 244 LILRRKLEKFISNLKLHPFTHSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSG 303
Query: 1021 RAADIISFAARYINSDGTFAAEVGEKLRNLIKMVFPET------DQEEMFRKITECVIRD 1182
RAAD+++F +Y SDG V E +R+ + +T E++++++ +C
Sbjct: 304 RAADLLAFVHKYA-SDGE-EQPVLESMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRNK 361
Query: 1183 DLLRIFRYGQEEE---EDVDFVILSTVLQKQNLPPDEQLALTLSWNRVDLAKSCLFSNGR 1353
+L+ +FR ++ E +++D IL+ + + Q+L P EQL+L L+WNRVD+A+S +F G+
Sbjct: 362 NLITVFRIQEKPEGEAQELDQTILTALFKSQHLSPPEQLSLALTWNRVDIARSEIFVYGQ 421
Query: 1354 KWSSDVLEKAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLYNMDDINSAHSVRNW 1533
+W + L++AM AL DR+DFV+ LLENGVSMK FL+I RLE LYN A+++
Sbjct: 422 EWPNGALDEAMMQALEHDRIDFVKLLLENGVSMKKFLTIPRLEELYNTKH-GPANTLGYI 480
Query: 1534 MENFDSMDPHTYL-TIPMIGQVVEKLMGNAFQLYYTSRSFKGKYDRYKRINQSSYFHRKR 1710
+ + P Y+ T+ IG V+ KLMG A++ YYT R F+ Y K +N + RK
Sbjct: 481 LRDVRPHIPKGYIYTLHDIGLVINKLMGGAYRSYYTRRKFRPIYA--KVMNSYANACRKS 538
Query: 1711 KIVQKELFKKKSDDQINDN----EEEDFSFAYPFNDLLIWAVLTSRHGMAECMWVHGEDA 1878
Q + + + + E F +PFN+LLIWAVLT R MA MW HGE+A
Sbjct: 539 STYQYQRYAGANSLSLVTGLLPFTSEMALFEFPFNELLIWAVLTKRQQMALLMWTHGEEA 598
Query: 1879 MAKCLLAIRLYKATAKIAEDEYLDVEEAKRLFDNAVKCREDAIELLDQCYRADHDRTLRL 2058
+AK L++ +LYKA A A ++ LD E + L A + +LLD YR D ++ RL
Sbjct: 599 LAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLDFSYRQDAEKAQRL 658
Query: 2059 LRMELPHWGNNNCLSLAVLANTKTFLAHPCCQILLAELWHGSLKVRSGSNVRVLTALICP 2238
L EL W N +CLSLAV AN + LAHPC Q++LA+LW G L+ R +N +V+ L P
Sbjct: 659 LTCELHSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVILGLAMP 718
Query: 2239 PAILFMAYKPKHSKTARLLSEETPEQLPYPRESITSTTSNRYRYSKGPEEQKETLLEKGS 2418
I + +K S+E +Q+P E + S + E LL +
Sbjct: 719 FYIRQLDFK----------SKEELQQMPQTEEEHLENQNLDNDDSDRSQPDAEALL-ADT 767
Query: 2419 YTKKVTIISSRKNXXXXXXXXXXXXXXF--------KREPQLNKFERFRAFYSSPITKFW 2574
Y+ + T + F K+ L ++F FY++PITKFW
Sbjct: 768 YSVRDTKVHENGKVSLTDSDTAQFREFFNLSEYNEVKQHQPLRLKKKFYEFYTAPITKFW 827
Query: 2575 SWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIYTVTLSVEHIRKLMTSEGSRINEKVK 2754
+ IA++ FL + +L++ P EW + Y TL E +R++++SE I K
Sbjct: 828 ADSIAYMFFLIMFSFTVLVKMEQMPRWQEWYSIAYITTLGFEKVREIISSEPVAITHKFS 887
Query: 2755 VFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSW---GRVLLSFSNVLFYMKIFEYLSVH 2925
V+ +N AA++ F++G FR +R + GRV+ ++ +Y++I L V+
Sbjct: 888 VWAWNMWNPCDGAAIILFVIGLAFR----FRENTMDIGRVIYCVDSIYWYLRILNILGVN 943
Query: 2926 PLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEPNVKDWHWLLVRNIFYKPYF 3105
LGP + M KMV +M Y VLL V LM+FGV+RQA+ PN K W L++ + ++PYF
Sbjct: 944 KYLGPLVTMMGKMVKNMIYFVVLLAVVLMSFGVSRQAILYPN-KQPTWSLIKEVTFQPYF 1002
Query: 3106 MLYGEVYAGEID-TCGDEGIR--CFPGYFIPPLLMXXXXXXXXXXXXXXXXXXXXXXYND 3276
MLYGEV+AG+ID CG++ + C G+++ P+ M +N+
Sbjct: 1003 MLYGEVFAGDIDPPCGEDPSQPGCVTGHWVTPITMSMYLLIANILLINLLIAVFNNIFNE 1062
Query: 3277 SIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDY 3402
S ++W+FQR+ +MEY P LPPPF H Y + Y
Sbjct: 1063 VNSVSHQVWMFQRFTVVMEYQQKPVLPPPFIALCHFYSLLKY 1104
>gi|29893552|ref|NP_060142.2| transient receptor potential cation
channel, subfamily M, member 7; LTRPC ion channel family
member 7 [Homo sapiens]
gi|13562153|gb|AAK19738.2| channel-kinase 1 [Homo sapiens]
Length = 1864
Score = 702 bits (1813), Expect = 0.0
Identities = 450/1410 (31%), Positives = 737/1410 (51%), Gaps = 91/1410 (6%)
Frame = +1
Query: 133 WIENTFEKRECIRFAALPKDPERC-------------GCGRPLSAHT--PASTFFSTLPV 267
WIE+T KREC+ KDP RC CGR + H AS V
Sbjct: 6 WIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLAMKYSDV 65
Query: 268 HLLEKEQQT---WTIANNTQTSTTDAFGTIVFQGGAHAHKAQYVRLSYDSEPLDVMYLME 438
L + Q W++ +T+ S TDA+G I FQGG+H+++A+YVRLSYD++P ++ L+
Sbjct: 66 KLGDHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPEVILQLLL 125
Query: 439 KVWGLEAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTTGAWIITSGLDSGVVRHVA 618
K W +E P+LVI+VHGGM FEL R+ +L KG++KAA TTGAWI+T G+++GV +HV
Sbjct: 126 KEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNTGVAKHVG 185
Query: 619 KALDEAGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYYDVHSLSVNANVGILNDRH 798
AL E ++R +I TIGIAPWGVI+ + L+ ++ Y L+ + + +LN+ H
Sbjct: 186 DALKEH--ASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQT-LLNPLSKLNVLNNLH 242
Query: 799 SYFLLADNGTVGRFGADLHLRQNLENHIATFGCN---GRKVPVVCTLLEGGISSINAIHD 969
S+F+L D+GTVG++GA++ LR+ LE I + G+ VPVV + EGG + I + +
Sbjct: 243 SHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVALIFEGGPNVILTVLE 302
Query: 970 YVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFAAEVGEKLRNLIKMVFPETDQE-- 1143
Y+ P +P +VC+G+GRAAD++++ + G + + IK F E
Sbjct: 303 YLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFNFGQNEAL 362
Query: 1144 EMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWNRVDL 1323
+F+ + EC+ R +L+ +F G +E +D+D IL+ +L+ N +QL LTL+W+RVD+
Sbjct: 363 HLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLKGTNASAFDQLILTLAWDRVDI 422
Query: 1324 AKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLYNMDD 1503
AK+ +F G++W LE+AM DAL DRV FV+ L+ENGVSM FL+I RLE LYN
Sbjct: 423 AKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHKFLTIPRLEELYNTKQ 482
Query: 1504 INSA----HSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNAFQLYYTSRSFK------ 1653
+ H VR+ + ++ P +T+ IG V+E LMG ++ YT + F+
Sbjct: 483 GPTNPMLFHLVRDVKQG--NLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSL 540
Query: 1654 GKYDRYKRINQSSYFHRKRK--------------------------------IVQKELFK 1737
G +R N SS + RK V +E K
Sbjct: 541 GGNNRRSGRNTSSSTPQLRKSHESFGNRADKKEKMRHNHFIKTAQPYRPKIDTVMEEGKK 600
Query: 1738 KKSDDQIND-NEEEDFSFAYPFNDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYK 1914
K++ D+I D ++ E F YP N+LLIWA L R MA +W HGE++MAK L+A ++Y+
Sbjct: 601 KRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYR 660
Query: 1915 ATAKIAEDEYLDVEEAKRLFDNAVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNN 2094
+ A A+ L + ++ L + + A+ELL+Q +R D ++LL EL +W N+
Sbjct: 661 SMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNST 720
Query: 2095 CLSLAVLANTKTFLAHPCCQILLAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKH 2274
CL LAV + + F+AH C Q+LL+++W G L +R S +V+ +++ PPAIL + YK K
Sbjct: 721 CLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKA 780
Query: 2275 SKTARLLSEETPEQLPYPRESITSTTSNRYRYSKGPEEQKETLLEK--GSYTKKVTIISS 2448
+ +P +++ T + E + + E+ K+V I+ S
Sbjct: 781 EMS----------HIPQSQDAHQMTMDD-------SENNFQNITEEIPMEVFKEVRILDS 823
Query: 2449 RKNXXXXXXXXXXXXXXFKREPQLNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILL 2628
+ + +L +F AFY +PI KFW +A+L FL T ++L
Sbjct: 824 NEGKNEMEIQ--------MKSKKLPITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVL 875
Query: 2629 LETSLKPSKYEWITFIYTVTLSVEHIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFF 2808
++ PS EWI Y T ++E +R++ SE ++N+K+KV+++ ++NI + A++ F
Sbjct: 876 VQMEQLPSVQEWIVIAYIFTYAIEKVREIFMSEAGKVNQKIKVWFSDYFNISDTIAIISF 935
Query: 2809 LVGYGFRLVPMYRHS---------WGRVLLSFSNVLFYMKIFEYLSVHPLLGPYIQMAAK 2961
+G+G R + + GR++ + + +Y+++ ++L+V+ GPY+ M K
Sbjct: 936 FIGFGLRFGAKWNFANAYDNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGK 995
Query: 2962 MVWSMCYICVLLLVPLMAFGVNRQALTEPNVKDWHWLLVRNIFYKPYFMLYGEVYAGEID 3141
MV +M YI V++ + L++FGV R+A+ P+ W L ++I + PY+M++GEVYA EID
Sbjct: 996 MVANMFYIVVIMALVLLSFGVPRKAILYPHEAP-SWTLAKDIVFHPYWMIFGEVYAYEID 1054
Query: 3142 TCGDEGI---RCFPGYFIPPLLMXXXXXXXXXXXXXXXXXXXXXXYNDSIEKSKEIWLFQ 3312
C ++ + C PG ++ P L Y S +W +Q
Sbjct: 1055 VCANDSVIPQICGPGTWLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQ 1114
Query: 3313 RYQQLMEYHDSPFLPPPFSIFAHVYHFIDYLYNLRRPDTKRFRSEHSIKLSVTEDEMKRI 3492
RY +M YH+ P LPPP I +H+ + R+ D ++ KL +TE++ K++
Sbjct: 1115 RYHFIMAYHEKPVLPPPLIILSHIVSLFCCICKRRKKD----KTSDGPKLFLTEEDQKKL 1170
Query: 3493 QDFEEDCIDTLTRIR--KLKLNTKEPLSVT-DLTELTCQRVHDLMQENFLLKSRVYDIET 3663
DFEE C++ + K ++E + VT + E C ++ ++ +K + +++
Sbjct: 1171 HDFEEQCVEMYFNEKDDKFHSGSEERIRVTFERVEQMCIQIKEVGDRVNYIKRSLQSLDS 1230
Query: 3664 KIDHISNSSDEVVQILKNKKLSQNFAASSLSLPDTSIEVPKITKTL-IDCHLSPVSIEDR 3840
+I H+ + S V LK + AS + +IT+ L I HL+ I+D
Sbjct: 1231 QIGHLQDLSALTVDTLKTLTAQKASEASKVH--------NEITRELSISKHLAQNLIDD- 1281
Query: 3841 LATRSPLLANLQRDHTLRKYDDANFQPGKLQRRARLHSSSCSI-SQDMKEMKTSMSSRNL 4017
P+ ++ + H + ++ G L+ H C+I +D K+ + ++ ++L
Sbjct: 1282 ----GPVRPSVWKKHGVVNTLSSSLPQGDLESNNPFH---CNILMKDDKDPQCNIFGQDL 1334
Query: 4018 ------KREDSGEITTSSHGGYDSDVSGPD 4089
K + E +SS + S VS P+
Sbjct: 1335 PAVPQRKEFNFPEAGSSSGALFPSAVSPPE 1364
>gi|13959785|gb|AAK44211.1| LTRPC7 [Homo sapiens]
Length = 1865
Score = 702 bits (1813), Expect = 0.0
Identities = 450/1410 (31%), Positives = 737/1410 (51%), Gaps = 91/1410 (6%)
Frame = +1
Query: 133 WIENTFEKRECIRFAALPKDPERC-------------GCGRPLSAHT--PASTFFSTLPV 267
WIE+T KREC+ KDP RC CGR + H AS V
Sbjct: 6 WIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLAMKYSDV 65
Query: 268 HLLEKEQQT---WTIANNTQTSTTDAFGTIVFQGGAHAHKAQYVRLSYDSEPLDVMYLME 438
L + Q W++ +T+ S TDA+G I FQGG+H+++A+YVRLSYD++P ++ L+
Sbjct: 66 KLGDHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPEVILQLLL 125
Query: 439 KVWGLEAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTTGAWIITSGLDSGVVRHVA 618
K W +E P+LVI+VHGGM FEL R+ +L KG++KAA TTGAWI+T G+++GV +HV
Sbjct: 126 KEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNTGVAKHVG 185
Query: 619 KALDEAGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYYDVHSLSVNANVGILNDRH 798
AL E ++R +I TIGIAPWGVI+ + L+ ++ Y L+ + + +LN+ H
Sbjct: 186 DALKEH--ASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQT-LLNPLSKLNVLNNLH 242
Query: 799 SYFLLADNGTVGRFGADLHLRQNLENHIATFGCN---GRKVPVVCTLLEGGISSINAIHD 969
S+F+L D+GTVG++GA++ LR+ LE I + G+ VPVV + EGG + I + +
Sbjct: 243 SHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVALIFEGGPNVILTVLE 302
Query: 970 YVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFAAEVGEKLRNLIKMVFPETDQE-- 1143
Y+ P +P +VC+G+GRAAD++++ + G + + IK F E
Sbjct: 303 YLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFNFGQNEAL 362
Query: 1144 EMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWNRVDL 1323
+F+ + EC+ R +L+ +F G +E +D+D IL+ +L+ N +QL LTL+W+RVD+
Sbjct: 363 HLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLKGTNASAFDQLILTLAWDRVDI 422
Query: 1324 AKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLYNMDD 1503
AK+ +F G++W LE+AM DAL DRV FV+ L+ENGVSM FL+I RLE LYN
Sbjct: 423 AKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHKFLTIPRLEELYNTKQ 482
Query: 1504 INSA----HSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNAFQLYYTSRSFK------ 1653
+ H VR+ + ++ P +T+ IG V+E LMG ++ YT + F+
Sbjct: 483 GPTNPMLFHLVRDVKQG--NLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSL 540
Query: 1654 GKYDRYKRINQSSYFHRKRK--------------------------------IVQKELFK 1737
G +R N SS + RK V +E K
Sbjct: 541 GGNNRRSGRNTSSSTPQLRKSHESFGNRADKKEKMRHNHFIKTAQPYRPKIDTVMEEGKK 600
Query: 1738 KKSDDQIND-NEEEDFSFAYPFNDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYK 1914
K++ D+I D ++ E F YP N+LLIWA L R MA +W HGE++MAK L+A ++Y+
Sbjct: 601 KRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYR 660
Query: 1915 ATAKIAEDEYLDVEEAKRLFDNAVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNN 2094
+ A A+ L + ++ L + + A+ELL+Q +R D ++LL EL +W N+
Sbjct: 661 SMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNST 720
Query: 2095 CLSLAVLANTKTFLAHPCCQILLAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKH 2274
CL LAV + + F+AH C Q+LL+++W G L +R S +V+ +++ PPAIL + YK K
Sbjct: 721 CLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKA 780
Query: 2275 SKTARLLSEETPEQLPYPRESITSTTSNRYRYSKGPEEQKETLLEK--GSYTKKVTIISS 2448
+ +P +++ T + E + + E+ K+V I+ S
Sbjct: 781 EMS----------HIPQSQDAHQMTMDD-------SENNFQNITEEIPMEVFKEVRILDS 823
Query: 2449 RKNXXXXXXXXXXXXXXFKREPQLNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILL 2628
+ + +L +F AFY +PI KFW +A+L FL T ++L
Sbjct: 824 NEGKNEMEIQ--------MKSKKLPITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVL 875
Query: 2629 LETSLKPSKYEWITFIYTVTLSVEHIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFF 2808
++ PS EWI Y T ++E +R++ SE ++N+K+KV+++ ++NI + A++ F
Sbjct: 876 VQMEQLPSVQEWIVIAYIFTYAIEKVREIFMSEAGKVNQKIKVWFSDYFNISDTIAIISF 935
Query: 2809 LVGYGFRLVPMYRHS---------WGRVLLSFSNVLFYMKIFEYLSVHPLLGPYIQMAAK 2961
+G+G R + + GR++ + + +Y+++ ++L+V+ GPY+ M K
Sbjct: 936 FIGFGLRFGAKWNFANAYDNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGK 995
Query: 2962 MVWSMCYICVLLLVPLMAFGVNRQALTEPNVKDWHWLLVRNIFYKPYFMLYGEVYAGEID 3141
MV +M YI V++ + L++FGV R+A+ P+ W L ++I + PY+M++GEVYA EID
Sbjct: 996 MVANMFYIVVIMALVLLSFGVPRKAILYPHEAP-SWTLAKDIVFHPYWMIFGEVYAYEID 1054
Query: 3142 TCGDEGI---RCFPGYFIPPLLMXXXXXXXXXXXXXXXXXXXXXXYNDSIEKSKEIWLFQ 3312
C ++ + C PG ++ P L Y S +W +Q
Sbjct: 1055 VCANDSVIPQICGPGTWLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQ 1114
Query: 3313 RYQQLMEYHDSPFLPPPFSIFAHVYHFIDYLYNLRRPDTKRFRSEHSIKLSVTEDEMKRI 3492
RY +M YH+ P LPPP I +H+ + R+ D ++ KL +TE++ K++
Sbjct: 1115 RYHFIMAYHEKPVLPPPLIILSHIVSLFCCICKRRKKD----KTSDGPKLFLTEEDQKKL 1170
Query: 3493 QDFEEDCIDTLTRIR--KLKLNTKEPLSVT-DLTELTCQRVHDLMQENFLLKSRVYDIET 3663
DFEE C++ + K ++E + VT + E C ++ ++ +K + +++
Sbjct: 1171 HDFEEQCVEMYFNEKDDKFHSGSEERIRVTFERVEQMCIQIKEVGDRVNYIKRSLQSLDS 1230
Query: 3664 KIDHISNSSDEVVQILKNKKLSQNFAASSLSLPDTSIEVPKITKTL-IDCHLSPVSIEDR 3840
+I H+ + S V LK + AS + +IT+ L I HL+ I+D
Sbjct: 1231 QIGHLQDLSALTVDTLKTLTAQKASEASKVH--------NEITRELSISKHLAQNLIDD- 1281
Query: 3841 LATRSPLLANLQRDHTLRKYDDANFQPGKLQRRARLHSSSCSI-SQDMKEMKTSMSSRNL 4017
P+ ++ + H + ++ G L+ H C+I +D K+ + ++ ++L
Sbjct: 1282 ----GPVRPSVWKKHGVVNTLSSSLPQGDLESNNPFH---CNILMKDDKDPQCNIFGQDL 1334
Query: 4018 ------KREDSGEITTSSHGGYDSDVSGPD 4089
K + E +SS + S VS P+
Sbjct: 1335 PAVPQRKEFNFPEAGSSSGALFPSAVSPPE 1364
>gi|50753109|ref|XP_425074.1| PREDICTED: similar to transient receptor
potential cation channel, subfamily M, member 7; LTRPC
ion channel family member 7 [Gallus gallus]
Length = 2008
Score = 695 bits (1794), Expect = 0.0
Identities = 437/1322 (33%), Positives = 705/1322 (53%), Gaps = 87/1322 (6%)
Frame = +1
Query: 133 WIENTFEKRECIRFAALPKDPERC-------------GCGRPLSAHT--PASTFFSTLPV 267
WIENTF KREC+ KDP RC CGR + H AS V
Sbjct: 30 WIENTFTKRECVYIIPSSKDPHRCLPGCQICQQLVRCCCGRLVRQHACFTASLAMKYSDV 89
Query: 268 HLLE---KEQQTWTIANNTQTSTTDAFGTIVFQGGAHAHKAQYVRLSYDSEPLDVMYLME 438
L E +E + W++ +T+ ++TDA+G I FQGG+H+++A+YVRLSYD++P ++ LM
Sbjct: 90 KLGENCNQEIEEWSVEKHTEQTSTDAYGVINFQGGSHSYRAKYVRLSYDTKPEAILQLML 149
Query: 439 KVWGLEAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTTGAWIITSGLDSGVVRHVA 618
K W +E P+LVI+VHGGM FEL R+ +L KG++KAA TTGAWIIT G+++GV +HV
Sbjct: 150 KEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWIITGGVNTGVAKHVG 209
Query: 619 KALDEAGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYYDVHSLSVNANVGILNDRH 798
AL E ++R +I TIGIAPWGVI+ + L+ ++ Y L+ + + +LN+ H
Sbjct: 210 DALREH--ASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQT-LLNPLSKLNVLNNLH 266
Query: 799 SYFLLADNGTVGRFGADLHLRQNLENHIATFGCN---GRKVPVVCTLLEGGISSINAIHD 969
S+F+L D+GTVG++GA++ LR+ LE I + G+ VPVV + EGG + I + D
Sbjct: 267 SHFILVDDGTVGKYGAEVKLRRELEKTINLQRIHARIGQGVPVVALVFEGGPNVILTVLD 326
Query: 970 YVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFAAEVGEKLRNLIKMV--FPETDQE 1143
++ P +P +VC+G+GRAADI+++ + G ++ + IK F +++
Sbjct: 327 FLHESPPVPVVVCEGTGRAADILAYVHKQTEEGGNVPEGAEPEIISTIKKTFNFGQSEAV 386
Query: 1144 EMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWNRVDL 1323
+F+ + EC+ + +L+ +F G +E +D+D IL+ +L+ N +QL LTL+W+RVD+
Sbjct: 387 HLFQTLLECMKKKELITVFHIGSDEHQDIDVAILTALLKGTNASAFDQLVLTLAWDRVDI 446
Query: 1324 AKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLYNM-- 1497
AK+ +F G++W LE+AM DAL DRV FV+ L+ENGVSM FL+I RLE LYN
Sbjct: 447 AKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHKFLTIPRLEELYNTKQ 506
Query: 1498 --DDINSAHSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNAFQLYYTSRSFKGKY--- 1662
+ H VR+ + ++ P + + +G V+E LMG ++ YT + F+ Y
Sbjct: 507 GPTNPTLFHLVRDVKQG--NLPPGYKINLIDVGLVIEYLMGGTYRCTYTRKRFRAIYNSL 564
Query: 1663 -----------------------------DRYKRINQSSYFHRKRKIVQK------ELFK 1737
D+ +++ + + + K E K
Sbjct: 565 SGNNRRSGRNPSNTTPQLCKSHESFGNRADKKEKMRHNHFIKTAQPYKPKIDTGAEEGKK 624
Query: 1738 KKSDDQIND-NEEEDFSFAYPFNDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYK 1914
K++ D+I D ++ E F YP N+LL+WAVL R MA W HGE++MAK L+A ++Y+
Sbjct: 625 KRTKDEIVDIDDPETRRFPYPLNELLLWAVLMKRQKMALFFWQHGEESMAKALVACKVYR 684
Query: 1915 ATAKIAEDEYLDVEEAKRLFDNAVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNN 2094
+ A A+ L + ++ L + + + A+ELL+Q +R D ++LL EL +W N+
Sbjct: 685 SMAYEAKQSDLVDDTSEELKQYSNEFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNST 744
Query: 2095 CLSLAVLANTKTFLAHPCCQILLAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKH 2274
CL LAV + + F+AH C Q+LL+++W G L +R S +V+ +++ PPAIL + YK K
Sbjct: 745 CLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILLPPAILLLEYKTKA 804
Query: 2275 SKTARLLSEETPEQLPYPRESITSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRK 2454
+ S++ + E+ T++ P E + + S T+K + + K
Sbjct: 805 EMSHIPQSQDAHQMAMDDSENNFQNTADEI-----PMEVFKEVRILDSTTEKHDMETPAK 859
Query: 2455 NXXXXXXXXXXXXXXFKREPQLNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLE 2634
KR P K F AFY +PI KFW +A+L FL T ++L++
Sbjct: 860 P---------------KRLPITQK---FYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVK 901
Query: 2635 TSLKPSKYEWITFIYTVTLSVEHIRKL-MTSEGSRINEKVKVFYAKWYNIWTSAALLFFL 2811
PS EWI Y T ++E IR++ SE +IN+K+KV+++ ++NI + A++ F
Sbjct: 902 MEEVPSVQEWIVIAYIFTSAIEKIREIFFMSEAGKINQKIKVWFSDYFNISDTVAIVTFF 961
Query: 2812 VGYGFRL-------VPMYRHSW----GRVLLSFSNVLFYMKIFEYLSVHPLLGPYIQMAA 2958
+G+ R YR ++ GR+ + + +Y+++ ++L+V+ GPY+ M
Sbjct: 962 IGFVLRFGAKGNFGENTYRENYIFVAGRITYCLNIIFWYVRLLDFLAVNQQAGPYVMMIG 1021
Query: 2959 KMVWSMCYICVLLLVPLMAFGVNRQALTEPNVKDWHWLLVRNIFYKPYFMLYGEVYAGEI 3138
KMV +M YI V++ + L++FGV R+A+ PN W L R+I + PY+M++GEVYA EI
Sbjct: 1022 KMVANMFYIVVIMALVLLSFGVPRKAILYPNEAP-SWTLARDIVFHPYWMIFGEVYAYEI 1080
Query: 3139 DTCGDEGIR-----CFPGYFIPPLLMXXXXXXXXXXXXXXXXXXXXXXYNDSIEKSKEIW 3303
D C + C PG ++ P L Y S +W
Sbjct: 1081 DVCANNSESQVAHLCGPGTWLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVW 1140
Query: 3304 LFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDYLYNLRRPDTKRFRSEHSIKLSVTEDEM 3483
+QRY +M YH+ P LPPP I +H+ + + R+ D ++ KL +TE++
Sbjct: 1141 KYQRYHFIMAYHEKPVLPPPLIILSHMASLLCCICKRRKTD----KTSDGPKLFLTEEDQ 1196
Query: 3484 KRIQDFEEDCIDTLTRIR--KLKLNTKEPLSVT-DLTELTCQRVHDLMQENFLLKSRVYD 3654
K++ DFEE C++ + K ++E + VT + E C ++ ++ +K +
Sbjct: 1197 KKLHDFEELCVEMYFNEKDDKFHSGSEERIRVTFERVEQMCIQIKEVGDRVNYIKRSLQS 1256
Query: 3655 IETKIDHISNSSDEVVQILKNKKLSQNFAASSLSLPDTSIEVPKITKTL-IDCHLSPVSI 3831
++++I H+ + S V LK + AS + +IT+ L I HL+ I
Sbjct: 1257 LDSQIGHLQDLSALTVDTLKTLTAQKASEASKVH--------NEITRELSISKHLAQNLI 1308
Query: 3832 ED 3837
+D
Sbjct: 1309 DD 1310
>gi|10946830|ref|NP_067425.1| transient receptor potential cation
channel, subfamily M, member 7; transient receptor
potential-related protein, ChaK; transient receptor
potential M7 [Mus musculus]
gi|8131903|gb|AAF73131.1| transient receptor potential-related
protein [Mus musculus]
Length = 1863
Score = 691 bits (1784), Expect = 0.0
Identities = 427/1317 (32%), Positives = 699/1317 (52%), Gaps = 82/1317 (6%)
Frame = +1
Query: 133 WIENTFEKRECIRFAALPKDPERC-------------GCGRPLSAHT--PASTFFSTLPV 267
WIE+T KREC+ KDP RC CGR + H AS V
Sbjct: 6 WIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLAMKYSDV 65
Query: 268 HLLEKEQQT---WTIANNTQTSTTDAFGTIVFQGGAHAHKAQYVRLSYDSEPLDVMYLME 438
L E Q W++ +T+ S TDA+G I FQGG+H+++A+YVRLSYD++P ++ L+
Sbjct: 66 RLGEHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPEIILQLLL 125
Query: 439 KVWGLEAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTTGAWIITSGLDSGVVRHVA 618
K W +E P+LVI+VHGGM FEL R+ +L KG++KAA TTGAWI+T G+++GV +HV
Sbjct: 126 KEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNTGVAKHVG 185
Query: 619 KALDEAGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYYDVHSLSVNANVGILNDRH 798
AL E ++R +I TIGIAPWGVI+ + L+ ++ Y L+ + + +LN+ H
Sbjct: 186 DALKEH--ASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQT-LLNPLSKLNVLNNLH 242
Query: 799 SYFLLADNGTVGRFGADLHLRQNLENHIATFGCN---GRKVPVVCTLLEGGISSINAIHD 969
S+F+L D+GTVG++GA++ LR+ LE I + G+ VPVV + EGG + I + +
Sbjct: 243 SHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVALIFEGGPNVILTVLE 302
Query: 970 YVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFAAEVGEKLRNLIKMVFP--ETDQE 1143
Y+ P +P +VC+G+GRAAD++++ + G + + IK F +++
Sbjct: 303 YLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFNFGQSEAV 362
Query: 1144 EMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWNRVDL 1323
+F+ + EC+ + +L+ +F G E+ +D+D IL+ +L+ N +QL LTL+W+RVD+
Sbjct: 363 HLFQTMMECMKKKELITVFHIGSEDHQDIDVAILTALLKGTNASAFDQLILTLAWDRVDI 422
Query: 1324 AKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLYNMDD 1503
AK+ +F G++W LE+AM DAL DRV FV+ L+ENGVSM FL+I RLE LYN
Sbjct: 423 AKNHVFVYGQQWLVGSLEQAMLDALVMDRVSFVKLLIENGVSMHKFLTIPRLEELYNTKQ 482
Query: 1504 INSA----HSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNAFQLYYTSRSFKGKY--- 1662
+ H +R+ + ++ P +T+ IG V+E LMG ++ YT + F+ Y
Sbjct: 483 GPTNPMLFHLIRDVKQG--NLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSL 540
Query: 1663 -----------------------------DRYKRINQSSY------FHRKRKIVQKELFK 1737
D+ +++ + + + K +E K
Sbjct: 541 GGNNRRSGRNTSSSTPQLRKSHETFGNRADKKEKMRHNHFIKTAQPYRPKMDASMEEGKK 600
Query: 1738 KKSDDQIND-NEEEDFSFAYPFNDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYK 1914
K++ D+I D ++ E F YP N+LLIWA L R MA +W HGE++MAK L+A ++Y+
Sbjct: 601 KRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYR 660
Query: 1915 ATAKIAEDEYLDVEEAKRLFDNAVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNN 2094
+ A A+ L + ++ L + + A+ELL+Q +R D ++LL EL +W N+
Sbjct: 661 SMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNST 720
Query: 2095 CLSLAVLANTKTFLAHPCCQILLAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKH 2274
CL LAV + + F+AH C Q+LL+++W G L +R S +V+ +++ PPAIL + YK K
Sbjct: 721 CLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILMLEYKTKA 780
Query: 2275 SKTARLLSEETPEQLPYPRESITSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRK 2454
+ S++ +T S ++ E E E K+ S K
Sbjct: 781 EMSHIPQSQDA--------HQMTMEDSENNFHNITEEIPMEVFKE-----VKILDSSDGK 827
Query: 2455 NXXXXXXXXXXXXXXFKREPQLNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLE 2634
N + +L +F AFY +PI KFW +A+L FL T ++L++
Sbjct: 828 NEMEIHI----------KSKKLPITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVK 877
Query: 2635 TSLKPSKYEWITFIYTVTLSVEHIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLV 2814
PS EWI Y T ++E +R++ SE +I++K+KV+++ ++N+ + A++ F V
Sbjct: 878 MEQLPSVQEWIVIAYIFTYAIEKVREVFMSEAGKISQKIKVWFSDYFNVSDTIAIISFFV 937
Query: 2815 GYGFRLVPMYRH---------SWGRVLLSFSNVLFYMKIFEYLSVHPLLGPYIQMAAKMV 2967
G+G R + + GR++ + + +Y+++ ++L+V+ GPY+ M KMV
Sbjct: 938 GFGLRFGAKWNYINAYDNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMV 997
Query: 2968 WSMCYICVLLLVPLMAFGVNRQALTEPNVKDWHWLLVRNIFYKPYFMLYGEVYAGEIDTC 3147
+M YI V++ + L++FGV R+A+ P+ ++ W L ++I + PY+M++GEVYA EID C
Sbjct: 998 ANMFYIVVIMALVLLSFGVPRKAILYPH-EEPSWSLAKDIVFHPYWMIFGEVYAYEIDVC 1056
Query: 3148 GDEGIR---CFPGYFIPPLLMXXXXXXXXXXXXXXXXXXXXXXYNDSIEKSKEIWLFQRY 3318
++ C PG ++ P L Y S +W +QRY
Sbjct: 1057 ANDSTLPTICGPGTWLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRY 1116
Query: 3319 QQLMEYHDSPFLPPPFSIFAHVYHFIDYLYNLRRPDTKRFRSEHSIKLSVTEDEMKRIQD 3498
+M YH+ P LPPP I +H+ + R+ D ++ KL +TE++ K++ D
Sbjct: 1117 HFIMAYHEKPVLPPPLIILSHIVSLFCCVCKRRKKD----KTSDGPKLFLTEEDQKKLHD 1172
Query: 3499 FEEDCIDTLTRIRKLKLN--TKEPLSVT-DLTELTCQRVHDLMQENFLLKSRVYDIETKI 3669
FEE C++ + K N ++E + VT + E ++ ++ +K + ++++I
Sbjct: 1173 FEEQCVEMYFDEKDDKFNSGSEERIRVTFERVEQMSIQIKEVGDRVNYIKRSLQSLDSQI 1232
Query: 3670 DHISNSSDEVVQILKNKKLSQNFAASSLSLPDTSIEVPKITKTL-IDCHLSPVSIED 3837
H+ + S V LK + AS + +IT+ L I HL+ I+D
Sbjct: 1233 GHLQDLSALTVDTLKTLTAQKASEASKVH--------NEITRELSISKHLAQNLIDD 1281
>gi|14211383|gb|AAK57433.1| transient receptor potential phospholipase
C interacting kinase [Mus musculus]
Length = 1862
Score = 691 bits (1783), Expect = 0.0
Identities = 427/1317 (32%), Positives = 699/1317 (52%), Gaps = 82/1317 (6%)
Frame = +1
Query: 133 WIENTFEKRECIRFAALPKDPERC-------------GCGRPLSAHT--PASTFFSTLPV 267
WIE+T KREC+ KDP RC CGR + H AS V
Sbjct: 6 WIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLAMKYSDV 65
Query: 268 HLLEKEQQT---WTIANNTQTSTTDAFGTIVFQGGAHAHKAQYVRLSYDSEPLDVMYLME 438
L E Q W++ +T+ S TDA+G I FQGG+H+++A+YVRLSYD++P ++ L+
Sbjct: 66 KLGEHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPEIILQLLL 125
Query: 439 KVWGLEAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTTGAWIITSGLDSGVVRHVA 618
K W +E P+LVI+VHGGM FEL R+ +L KG++KAA TTGAWI+T G+++GV +HV
Sbjct: 126 KEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNTGVAKHVG 185
Query: 619 KALDEAGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYYDVHSLSVNANVGILNDRH 798
AL E ++R +I TIGIAPWGVI+ + L+ ++ Y L+ + + +LN+ H
Sbjct: 186 DALKEH--ASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQT-LLNPLSKLNVLNNLH 242
Query: 799 SYFLLADNGTVGRFGADLHLRQNLENHIATFGCN---GRKVPVVCTLLEGGISSINAIHD 969
S+F+L D+GTVG++GA++ LR+ LE I + G+ VPVV + EGG + I + +
Sbjct: 243 SHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVALIFEGGPNVILTVLE 302
Query: 970 YVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFAAEVGEKLRNLIKMVFP--ETDQE 1143
Y+ P +P +VC+G+GRAAD++++ + G + + IK F +++
Sbjct: 303 YLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFNFGQSEAV 362
Query: 1144 EMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWNRVDL 1323
+F+ + EC+ + +L+ +F G E+ +D+D IL+ +L+ N +QL LTL+W+RVD+
Sbjct: 363 HLFQTMMECMKKKELITVFHIGSEDHQDIDVAILTALLKGTNASAFDQLILTLAWDRVDI 422
Query: 1324 AKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLYNMDD 1503
AK+ +F G++W LE+AM DAL DRV FV+ L+ENGVSM FL+I RLE LYN
Sbjct: 423 AKNHVFVYGQQWLVGSLEQAMLDALVMDRVSFVKLLIENGVSMHKFLTIPRLEELYNTKQ 482
Query: 1504 INSA----HSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNAFQLYYTSRSFKGKY--- 1662
+ H +R+ + ++ P +T+ IG V+E LMG ++ YT + F+ Y
Sbjct: 483 GPTNPMLFHLIRDVKQG--NLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSL 540
Query: 1663 -----------------------------DRYKRINQSSY------FHRKRKIVQKELFK 1737
D+ +++ + + + K +E K
Sbjct: 541 GGNNRRSGRNTSSSTPQLRKSHETFGNRADKKEKMRHNHFIKTAQPYRPKMDASMEEGKK 600
Query: 1738 KKSDDQIND-NEEEDFSFAYPFNDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYK 1914
K++ D+I D ++ E F YP N+LLIWA L R MA +W HGE++MAK L+A ++Y+
Sbjct: 601 KRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYR 660
Query: 1915 ATAKIAEDEYLDVEEAKRLFDNAVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNN 2094
+ A A+ L + ++ L + + A+ELL+Q +R D ++LL EL +W N+
Sbjct: 661 SMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNST 720
Query: 2095 CLSLAVLANTKTFLAHPCCQILLAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKH 2274
CL LAV + + F+AH C Q+LL+++W G L +R S +V+ +++ PPAIL + YK K
Sbjct: 721 CLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILMLEYKTKA 780
Query: 2275 SKTARLLSEETPEQLPYPRESITSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRK 2454
+ S++ +T S ++ E E E K+ S K
Sbjct: 781 EMSHIPQSQDA--------HQMTMEDSENNFHNITEEIPMEVFKE-----VKILDSSDGK 827
Query: 2455 NXXXXXXXXXXXXXXFKREPQLNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLE 2634
N + +L +F AFY +PI KFW +A+L FL T ++L++
Sbjct: 828 NEMEIHI----------KSKKLPITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVK 877
Query: 2635 TSLKPSKYEWITFIYTVTLSVEHIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLV 2814
PS EWI Y T ++E +R++ SE +I++K+KV+++ ++N+ + A++ F V
Sbjct: 878 MEQLPSVQEWIVIAYIFTYAIEKVREVFMSEAGKISQKIKVWFSDYFNVSDTIAIISFFV 937
Query: 2815 GYGFRLVPMYRH---------SWGRVLLSFSNVLFYMKIFEYLSVHPLLGPYIQMAAKMV 2967
G+G R + + GR++ + + +Y+++ ++L+V+ GPY+ M KMV
Sbjct: 938 GFGLRFGAKWNYINAYDNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMV 997
Query: 2968 WSMCYICVLLLVPLMAFGVNRQALTEPNVKDWHWLLVRNIFYKPYFMLYGEVYAGEIDTC 3147
+M YI V++ + L++FGV R+A+ P+ ++ W L ++I + PY+M++GEVYA EID C
Sbjct: 998 ANMFYIVVIMALVLLSFGVPRKAILYPH-EEPSWSLAKDIVFHPYWMIFGEVYAYEIDVC 1056
Query: 3148 GDEGIR---CFPGYFIPPLLMXXXXXXXXXXXXXXXXXXXXXXYNDSIEKSKEIWLFQRY 3318
++ C PG ++ P L Y S +W +QRY
Sbjct: 1057 ANDSTLPTICGPGTWLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRY 1116
Query: 3319 QQLMEYHDSPFLPPPFSIFAHVYHFIDYLYNLRRPDTKRFRSEHSIKLSVTEDEMKRIQD 3498
+M YH+ P LPPP I +H+ + R+ D ++ KL +TE++ K++ D
Sbjct: 1117 HFIMAYHEKPVLPPPLIILSHIVSLFCCVCKRRKKD----KTSDGPKLFLTEEDQKKLHD 1172
Query: 3499 FEEDCIDTLTRIRKLKLN--TKEPLSVT-DLTELTCQRVHDLMQENFLLKSRVYDIETKI 3669
FEE C++ + K N ++E + VT + E ++ ++ +K + ++++I
Sbjct: 1173 FEEQCVEMYFDEKDDKFNSGSEERIRVTFERVEQMSIQIKEVGDRVNYIKRSLQSLDSQI 1232
Query: 3670 DHISNSSDEVVQILKNKKLSQNFAASSLSLPDTSIEVPKITKTL-IDCHLSPVSIED 3837
H+ + S V LK + AS + +IT+ L I HL+ I+D
Sbjct: 1233 GHLQDLSALTVDTLKTLTAQKASEASKVH--------NEITRELSISKHLAQNLIDD 1281
>gi|14009344|gb|AAK50377.1| LTRPC7 [Mus musculus]
Length = 1863
Score = 691 bits (1783), Expect = 0.0
Identities = 427/1317 (32%), Positives = 699/1317 (52%), Gaps = 82/1317 (6%)
Frame = +1
Query: 133 WIENTFEKRECIRFAALPKDPERC-------------GCGRPLSAHT--PASTFFSTLPV 267
WIE+T KREC+ KDP RC CGR + H AS V
Sbjct: 6 WIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLAMKYSDV 65
Query: 268 HLLEKEQQT---WTIANNTQTSTTDAFGTIVFQGGAHAHKAQYVRLSYDSEPLDVMYLME 438
L E Q W++ +T+ S TDA+G I FQGG+H+++A+YVRLSYD++P ++ L+
Sbjct: 66 KLGEHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPEIILQLLL 125
Query: 439 KVWGLEAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTTGAWIITSGLDSGVVRHVA 618
K W +E P+LVI+VHGGM FEL R+ +L KG++KAA TTGAWI+T G+++GV +HV
Sbjct: 126 KEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNTGVAKHVG 185
Query: 619 KALDEAGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYYDVHSLSVNANVGILNDRH 798
AL E ++R +I TIGIAPWGVI+ + L+ ++ Y L+ + + +LN+ H
Sbjct: 186 DALKEH--ASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQT-LLNPLSKLNVLNNLH 242
Query: 799 SYFLLADNGTVGRFGADLHLRQNLENHIATFGCN---GRKVPVVCTLLEGGISSINAIHD 969
S+F+L D+GTVG++GA++ LR+ LE I + G+ VPVV + EGG + I + +
Sbjct: 243 SHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVALIFEGGPNVILTVLE 302
Query: 970 YVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFAAEVGEKLRNLIKMVFP--ETDQE 1143
Y+ P +P +VC+G+GRAAD++++ + G + + IK F +++
Sbjct: 303 YLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFNFGQSEAV 362
Query: 1144 EMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWNRVDL 1323
+F+ + EC+ + +L+ +F G E+ +D+D IL+ +L+ N +QL LTL+W+RVD+
Sbjct: 363 HLFQTMMECMKKKELITVFHIGSEDHQDIDVAILTALLKGTNASAFDQLILTLAWDRVDI 422
Query: 1324 AKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLYNMDD 1503
AK+ +F G++W LE+AM DAL DRV FV+ L+ENGVSM FL+I RLE LYN
Sbjct: 423 AKNHVFVYGQQWLVGSLEQAMLDALVMDRVSFVKLLIENGVSMHKFLTIPRLEELYNTKQ 482
Query: 1504 INSA----HSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNAFQLYYTSRSFKGKY--- 1662
+ H +R+ + ++ P +T+ IG V+E LMG ++ YT + F+ Y
Sbjct: 483 GPTNPMLFHLIRDVKQG--NLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSL 540
Query: 1663 -----------------------------DRYKRINQSSY------FHRKRKIVQKELFK 1737
D+ +++ + + + K +E K
Sbjct: 541 GGNNRRSGRNTSSSTPQLRKSHETFGNRADKKEKMRHNHFIKTAQPYRPKMDASMEEGKK 600
Query: 1738 KKSDDQIND-NEEEDFSFAYPFNDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYK 1914
K++ D+I D ++ E F YP N+LLIWA L R MA +W HGE++MAK L+A ++Y+
Sbjct: 601 KRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYR 660
Query: 1915 ATAKIAEDEYLDVEEAKRLFDNAVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNN 2094
+ A A+ L + ++ L + + A+ELL+Q +R D ++LL EL +W N+
Sbjct: 661 SMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNST 720
Query: 2095 CLSLAVLANTKTFLAHPCCQILLAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKH 2274
CL LAV + + F+AH C Q+LL+++W G L +R S +V+ +++ PPAIL + YK K
Sbjct: 721 CLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILMLEYKTKA 780
Query: 2275 SKTARLLSEETPEQLPYPRESITSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRK 2454
+ S++ +T S ++ E E E K+ S K
Sbjct: 781 EMSHIPQSQDA--------HQMTMEDSENNFHNITEEIPMEVFKE-----VKILDSSDGK 827
Query: 2455 NXXXXXXXXXXXXXXFKREPQLNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLE 2634
N + +L +F AFY +PI KFW +A+L FL T ++L++
Sbjct: 828 NEMEIHI----------KSKKLPITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVK 877
Query: 2635 TSLKPSKYEWITFIYTVTLSVEHIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLV 2814
PS EWI Y T ++E +R++ SE +I++K+KV+++ ++N+ + A++ F V
Sbjct: 878 MEQLPSVQEWIVIAYIFTYAIEKVREVFMSEAGKISQKIKVWFSDYFNVSDTIAIISFFV 937
Query: 2815 GYGFRLVPMYRH---------SWGRVLLSFSNVLFYMKIFEYLSVHPLLGPYIQMAAKMV 2967
G+G R + + GR++ + + +Y+++ ++L+V+ GPY+ M KMV
Sbjct: 938 GFGLRFGAKWNYINAYDNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMV 997
Query: 2968 WSMCYICVLLLVPLMAFGVNRQALTEPNVKDWHWLLVRNIFYKPYFMLYGEVYAGEIDTC 3147
+M YI V++ + L++FGV R+A+ P+ ++ W L ++I + PY+M++GEVYA EID C
Sbjct: 998 ANMFYIVVIMALVLLSFGVPRKAILYPH-EEPSWSLAKDIVFHPYWMIFGEVYAYEIDVC 1056
Query: 3148 GDEGIR---CFPGYFIPPLLMXXXXXXXXXXXXXXXXXXXXXXYNDSIEKSKEIWLFQRY 3318
++ C PG ++ P L Y S +W +QRY
Sbjct: 1057 ANDSTLPTICGPGTWLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRY 1116
Query: 3319 QQLMEYHDSPFLPPPFSIFAHVYHFIDYLYNLRRPDTKRFRSEHSIKLSVTEDEMKRIQD 3498
+M YH+ P LPPP I +H+ + R+ D ++ KL +TE++ K++ D
Sbjct: 1117 HFIMAYHEKPVLPPPLIILSHIVSLFCCVCKRRKKD----KTSDGPKLFLTEEDQKKLHD 1172
Query: 3499 FEEDCIDTLTRIRKLKLN--TKEPLSVT-DLTELTCQRVHDLMQENFLLKSRVYDIETKI 3669
FEE C++ + K N ++E + VT + E ++ ++ +K + ++++I
Sbjct: 1173 FEEQCVEMYFDEKDDKFNSGSEERIRVTFERVEQMSIQIKEVGDRVNYIKRSLQSLDSQI 1232
Query: 3670 DHISNSSDEVVQILKNKKLSQNFAASSLSLPDTSIEVPKITKTL-IDCHLSPVSIED 3837
H+ + S V LK + AS + +IT+ L I HL+ I+D
Sbjct: 1233 GHLQDLSALTVDTLKTLTAQKASEASKVH--------NEITRELSISKHLAQNLIDD 1281
>gi|45935360|ref|NP_996827.1| transient receptor potential cation
channel, subfamily M, member 3 isoform d; melastatin 2;
long transient receptor potential channel 3 [Homo
sapiens]
gi|28626253|gb|AAO49156.1| calcium-permeable store-operated channel
TRPM3d [Homo sapiens]
Length = 1544
Score = 687 bits (1772), Expect = 0.0
Identities = 394/1123 (35%), Positives = 637/1123 (56%), Gaps = 23/1123 (2%)
Frame = +1
Query: 385 YVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTT 564
YVR+S+D++P +++LM K W LE P+L+I+VHGG+ NFEL+ +L ++F KG++KAA TT
Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Query: 565 GAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYY 744
GAWI T G+++GV+RHV AL + +++ R +I TIGIAPWG+++ +E LI ++ Y
Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDH--ASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPY 119
Query: 745 DVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCN---GRKVP 915
S ++ + +LN HS+F+LADNGT G++GA++ LR+ LE HI+ N G+ VP
Sbjct: 120 QTMSNPMS-KLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVP 178
Query: 916 VVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFAAEVGE 1095
VV ++EGG + I+ + +Y+ P +P +VCDGSGRA+DI++F +Y G + +
Sbjct: 179 VVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRD 238
Query: 1096 KLRNLIKMVFP--ETDQEEMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQN 1269
+L I+ F T + +F + EC+ + +L+ +FR G E +D+D IL+ +L+ N
Sbjct: 239 QLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGAN 298
Query: 1270 LPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENGVS 1449
+QL+L L+WNRVD+A+S +F G++W LE+AM DAL DRVDFV+ L+ENGVS
Sbjct: 299 ASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVS 358
Query: 1450 MKNFLSINRLENLYNMDDINSA---HSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNA 1620
M FL+I+RLE LYN S H VR+ + ++ P +++ IG V+E LMG A
Sbjct: 359 MHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKG--NLPPDYRISLIDIGLVIEYLMGGA 416
Query: 1621 FQLYYTSRSFKGKYDRYKRINQSSYFHRKRKIVQKELFKKKSDDQINDNEEEDFSFAYPF 1800
++ YT + F+ Y + R+ + K K++ + I+ ++ E F +PF
Sbjct: 417 YRCNYTRKRFRTLYHNLFGPKRDDIPLRRGRKTTK---KREEEVDIDLDDPEINHFPFPF 473
Query: 1801 NDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEEAKRLFDN 1980
++L++WAVL R MA W HGE+AMAK L+A +L KA A A + + + ++ L N
Sbjct: 474 HELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHN 533
Query: 1981 AVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPCCQIL 2160
+ + A+ELLDQ Y+ D ++LL EL +W N CL LAV A + F+AH C Q+L
Sbjct: 534 SRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQML 593
Query: 2161 LAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQLPYPRESI 2340
L ++W G L++R S ++V+ ++ PP+IL + +K K + +PY
Sbjct: 594 LTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNK-------------DDMPY----- 635
Query: 2341 TSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKNXXXXXXXXXXXXXXFKREPQL 2520
S + K EE ++ EK ++T + R N R L
Sbjct: 636 MSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPL 695
Query: 2521 NKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIYTVTLSVE 2700
+ + FY++PI KFW + +A++ +L I+L++ PS EWI Y TL +E
Sbjct: 696 GR--KIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIE 753
Query: 2701 HIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSWGRVLLSFS 2880
+R+++ SE ++ +KVKV+ +++N+ A+L F VG RL S GRV+ +
Sbjct: 754 KMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVN 813
Query: 2881 NVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEPNVKD 3060
+ +Y+++ + V+ LGPY+ M KM+ M Y +++LV LM+FGV RQA+ PN ++
Sbjct: 814 IIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPN-EE 872
Query: 3061 WHWLLVRNIFYKPYFMLYGEVYAGEID-TCGDEGIR----------CFPGYFIPPLLMXX 3207
W L +NIFY PY+M+YGEV+A +ID CG R C G +I P +M
Sbjct: 873 PSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMAC 932
Query: 3208 XXXXXXXXXXXXXXXXXXXXYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVY 3387
+ + S ++W FQRYQ +M +H+ P LPPP IF+H+
Sbjct: 933 YLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMT 992
Query: 3388 HFIDYL-YNLRRPDTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTLTRIRKLKLNTK-- 3558
+L R+ ++ ++ +KL +T+DE+K++ DFEE CI+ R + + N+
Sbjct: 993 MIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSND 1052
Query: 3559 EPLSVT-DLTELTCQRVHDLMQENFLLKSRVYDIETKIDHISN 3684
E + VT + E R+ ++ + +K+ + ++ ++ + +
Sbjct: 1053 ERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLED 1095
>gi|27597209|dbj|BAC55104.1| hypothetical protein [Homo sapiens]
Length = 1544
Score = 687 bits (1772), Expect = 0.0
Identities = 394/1123 (35%), Positives = 637/1123 (56%), Gaps = 23/1123 (2%)
Frame = +1
Query: 385 YVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTT 564
YVR+S+D++P +++LM K W LE P+L+I+VHGG+ NFEL+ +L ++F KG++KAA TT
Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Query: 565 GAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYY 744
GAWI T G+++GV+RHV AL + +++ R +I TIGIAPWG+++ +E LI ++ Y
Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDH--ASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPY 119
Query: 745 DVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCN---GRKVP 915
S ++ + +LN HS+F+LADNGT G++GA++ LR+ LE HI+ N G+ VP
Sbjct: 120 QTMSNPMS-KLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVP 178
Query: 916 VVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFAAEVGE 1095
VV ++EGG + I+ + +Y+ P +P +VCDGSGRA+DI++F +Y G + +
Sbjct: 179 VVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRD 238
Query: 1096 KLRNLIKMVFP--ETDQEEMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQN 1269
+L I+ F T + +F + EC+ + +L+ +FR G E +D+D IL+ +L+ N
Sbjct: 239 QLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGAN 298
Query: 1270 LPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENGVS 1449
+QL+L L+WNRVD+A+S +F G++W LE+AM DAL DRVDFV+ L+ENGVS
Sbjct: 299 ASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVS 358
Query: 1450 MKNFLSINRLENLYNMDDINSA---HSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNA 1620
M FL+I+RLE LYN S H VR+ + ++ P +++ IG V+E LMG A
Sbjct: 359 MHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKG--NLPPDYRISLIDIGLVIEYLMGGA 416
Query: 1621 FQLYYTSRSFKGKYDRYKRINQSSYFHRKRKIVQKELFKKKSDDQINDNEEEDFSFAYPF 1800
++ YT + F+ Y + R+ + K K++ + I+ ++ E F +PF
Sbjct: 417 YRCNYTRKRFRTLYHNLFGPKRDDIPLRRGRKTTK---KREEEVDIDLDDPEINHFPFPF 473
Query: 1801 NDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEEAKRLFDN 1980
++L++WAVL R MA W HGE+AMAK L+A +L KA A A + + + ++ L N
Sbjct: 474 HELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHN 533
Query: 1981 AVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPCCQIL 2160
+ + A+ELLDQ Y+ D ++LL EL +W N CL LAV A + F+AH C Q+L
Sbjct: 534 SRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQML 593
Query: 2161 LAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQLPYPRESI 2340
L ++W G L++R S ++V+ ++ PP+IL + +K K + +PY
Sbjct: 594 LTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNK-------------DDMPY----- 635
Query: 2341 TSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKNXXXXXXXXXXXXXXFKREPQL 2520
S + K EE ++ EK ++T + R N R L
Sbjct: 636 MSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPL 695
Query: 2521 NKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIYTVTLSVE 2700
+ + FY++PI KFW + +A++ +L I+L++ PS EWI Y TL +E
Sbjct: 696 GR--KIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIE 753
Query: 2701 HIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSWGRVLLSFS 2880
+R+++ SE ++ +KVKV+ +++N+ A+L F VG RL S GRV+ +
Sbjct: 754 KMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVN 813
Query: 2881 NVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEPNVKD 3060
+ +Y+++ + V+ LGPY+ M KM+ M Y +++LV LM+FGV RQA+ PN ++
Sbjct: 814 IIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPN-EE 872
Query: 3061 WHWLLVRNIFYKPYFMLYGEVYAGEID-TCGDEGIR----------CFPGYFIPPLLMXX 3207
W L +NIFY PY+M+YGEV+A +ID CG R C G +I P +M
Sbjct: 873 PSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMAC 932
Query: 3208 XXXXXXXXXXXXXXXXXXXXYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVY 3387
+ + S ++W FQRYQ +M +H+ P LPPP IF+H+
Sbjct: 933 YLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMT 992
Query: 3388 HFIDYL-YNLRRPDTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTLTRIRKLKLNTK-- 3558
+L R+ ++ ++ +KL +T+DE+K++ DFEE CI+ R + + N+
Sbjct: 993 MIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSND 1052
Query: 3559 EPLSVT-DLTELTCQRVHDLMQENFLLKSRVYDIETKIDHISN 3684
E + VT + E R+ ++ + +K+ + ++ ++ + +
Sbjct: 1053 ERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLED 1095
>gi|45935362|ref|NP_996828.1| transient receptor potential cation
channel, subfamily M, member 3 isoform e; melastatin 2;
long transient receptor potential channel 3 [Homo
sapiens]
gi|28626255|gb|AAO49157.1| calcium-permeable store-operated channel
TRPM3e [Homo sapiens]
Length = 1556
Score = 686 bits (1770), Expect = 0.0
Identities = 395/1133 (34%), Positives = 638/1133 (55%), Gaps = 33/1133 (2%)
Frame = +1
Query: 385 YVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTT 564
YVR+S+D++P +++LM K W LE P+L+I+VHGG+ NFEL+ +L ++F KG++KAA TT
Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Query: 565 GAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYY 744
GAWI T G+++GV+RHV AL + +++ R +I TIGIAPWG+++ +E LI ++ Y
Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDH--ASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPY 119
Query: 745 DVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCN---GRKVP 915
S ++ + +LN HS+F+LADNGT G++GA++ LR+ LE HI+ N G+ VP
Sbjct: 120 QTMSNPMS-KLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVP 178
Query: 916 VVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFAAEVGE 1095
VV ++EGG + I+ + +Y+ P +P +VCDGSGRA+DI++F +Y G + +
Sbjct: 179 VVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRD 238
Query: 1096 KLRNLIKMVFP--ETDQEEMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQN 1269
+L I+ F T + +F + EC+ + +L+ +FR G E +D+D IL+ +L+ N
Sbjct: 239 QLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGAN 298
Query: 1270 LPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENGVS 1449
+QL+L L+WNRVD+A+S +F G++W LE+AM DAL DRVDFV+ L+ENGVS
Sbjct: 299 ASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVS 358
Query: 1450 MKNFLSINRLENLYNMDDINSA---HSVRN----------WMENFDSMDPHTYLTIPMIG 1590
M FL+I+RLE LYN S H VR+ W+ ++ P +++ IG
Sbjct: 359 MHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKREYPGFGWIYFKGNLPPDYRISLIDIG 418
Query: 1591 QVVEKLMGNAFQLYYTSRSFKGKYDRYKRINQSSYFHRKRKIVQKELFKKKSDDQINDNE 1770
V+E LMG A++ YT + F+ Y + R+ + K K++ + I+ ++
Sbjct: 419 LVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRDDIPLRRGRKTTK---KREEEVDIDLDD 475
Query: 1771 EEDFSFAYPFNDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLD 1950
E F +PF++L++WAVL R MA W HGE+AMAK L+A +L KA A A + +
Sbjct: 476 PEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMV 535
Query: 1951 VEEAKRLFDNAVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKT 2130
+ ++ L N+ + A+ELLDQ Y+ D ++LL EL +W N CL LAV A +
Sbjct: 536 DDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRD 595
Query: 2131 FLAHPCCQILLAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETP 2310
F+AH C Q+LL ++W G L++R S ++V+ ++ PP+IL + +K K
Sbjct: 596 FIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNK------------- 642
Query: 2311 EQLPYPRESITSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKNXXXXXXXXXXX 2490
+ +PY S + K EE ++ EK ++T + R N
Sbjct: 643 DDMPY-----MSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESSRKKDEEE 697
Query: 2491 XXXFKREPQLNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEWIT 2670
R L + + FY++PI KFW + +A++ +L I+L++ PS EWI
Sbjct: 698 VQSKHRLIPLGR--KIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIV 755
Query: 2671 FIYTVTLSVEHIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRH 2850
Y TL +E +R+++ SE ++ +KVKV+ +++N+ A+L F VG RL
Sbjct: 756 ISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFR 815
Query: 2851 SWGRVLLSFSNVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNR 3030
S GRV+ + + +Y+++ + V+ LGPY+ M KM+ M Y +++LV LM+FGV R
Sbjct: 816 SDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVAR 875
Query: 3031 QALTEPNVKDWHWLLVRNIFYKPYFMLYGEVYAGEID-TCGDEGIR----------CFPG 3177
QA+ PN ++ W L +NIFY PY+M+YGEV+A +ID CG R C G
Sbjct: 876 QAILFPN-EEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTG 934
Query: 3178 YFIPPLLMXXXXXXXXXXXXXXXXXXXXXXYNDSIEKSKEIWLFQRYQQLMEYHDSPFLP 3357
+I P +M + + S ++W FQRYQ +M +H+ P LP
Sbjct: 935 AWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLP 994
Query: 3358 PPFSIFAHVYHFIDYL-YNLRRPDTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTLTRI 3534
PP IF+H+ +L R+ ++ ++ +KL +T+DE+K++ DFEE CI+ R
Sbjct: 995 PPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFRE 1054
Query: 3535 RKLKLNTK--EPLSVT-DLTELTCQRVHDLMQENFLLKSRVYDIETKIDHISN 3684
+ + N+ E + VT + E R+ ++ + +K+ + ++ ++ + +
Sbjct: 1055 KDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLED 1107
>gi|47214200|emb|CAG00828.1| unnamed protein product [Tetraodon
nigroviridis]
Length = 2135
Score = 685 bits (1767), Expect = 0.0
Identities = 421/1317 (31%), Positives = 692/1317 (51%), Gaps = 109/1317 (8%)
Frame = +1
Query: 130 PWIENTFEKRECIRFAALPKDPERC-------------GCGRPLSAHTPASTFFSTL--- 261
PWIE+TF KREC+ + KDP RC CGR + H + ++
Sbjct: 94 PWIESTFSKRECVYILPVSKDPHRCLPGCQICQQLVRCCCGRLVRQHVGFTASLASKYSD 153
Query: 262 -----PVHLLEKEQQTWTIANNTQTSTTDAFGTIVFQGGAHAHKAQYVRLSYDSEPLDVM 426
V L + W++ +T+ S TDA+G I FQGG+H+++A+Y RLSYD+ P ++
Sbjct: 154 VKLGENVGLPTPAAEEWSVEKHTEASPTDAYGVINFQGGSHSYRAKYARLSYDTRPECIL 213
Query: 427 YLMEKVWGLEAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTTGAWIITSGLDSGVV 606
LM K W +E P+++I+VHGG+ NFEL R+ ++ KG++ AA TTGAWI+T G+++GV
Sbjct: 214 RLMLKEWQMELPKILISVHGGVQNFELHPRIKQVVGKGLINAAVTTGAWILTGGVNTGVA 273
Query: 607 RHVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYYDVHSLSVNANVGIL 786
+HV AL E +R +I TIGIAPWGVI+ + L+ ++ Y L+ + + L
Sbjct: 274 KHVGDALKEH--FSRSSKKICTIGIAPWGVIENRNDLLGRDIIAPYQT-LLNPLSKLNAL 330
Query: 787 NDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCN---GRKVPVVCTLLEGGISSIN 957
N HS+FLL D+GTVGR+GA+++LR+ LE HI + G+ VPVV + EGG + I
Sbjct: 331 NSLHSHFLLVDDGTVGRYGAEVNLRRQLEKHINLQRIHARIGQGVPVVALIFEGGPNVIL 390
Query: 958 AIHDYVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFAAEVGEKLRNLIKMV--FPE 1131
+ +Y+ P +P +VC+G+GRAADI+++ + G V + IK F +
Sbjct: 391 TVLEYLQESPPVPVVVCEGTGRAADILAYVHKQTEERGRLPDGVEADIIATIKKTFNFSQ 450
Query: 1132 TDQEEMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWN 1311
+D +F+ + EC+ +L+ +F EE +D+D IL +L+ N +QL LTL+W+
Sbjct: 451 SDAIHLFQTLMECMKSKELITVFHISSEEHQDIDVAILRALLKGTNASAFDQLVLTLAWD 510
Query: 1312 RVDLAKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLY 1491
RVD+AK+ +F G++ LE+AM DAL DRVDFV+ L+ENGVSM FL+I+RLE LY
Sbjct: 511 RVDIAKNHVFVYGQQLLVSSLEQAMLDALVMDRVDFVKLLIENGVSMHRFLTISRLEELY 570
Query: 1492 NM----DDINSAHSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNAFQLYYTSRSFKGK 1659
N ++ N H VR+ ++ + P+ +T+ IG V+E LMG ++ YT + F+
Sbjct: 571 NTKQPGNNPNLLHLVRDVKQS--HLPPNYKITLIDIGLVIEYLMGGTYRCNYTRKRFRII 628
Query: 1660 YDRYKRINQSSYFH-------------------RKRKIVQKELFK--------------- 1737
Y+ + ++ S H +K K + K
Sbjct: 629 YNNLRGNSRRSGRHSAPGSHLRRNHETFSMEADKKEKTRHNQFIKTAQPYKPKLESSSEQ 688
Query: 1738 --KKSDDQIND-NEEEDFSFAYPFNDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRL 1908
K+S ++I D ++ E F YPFN+LL+WAVL R M+ W HGE+ MAK L+A +L
Sbjct: 689 KTKRSKEEIVDIDDPETRRFPYPFNELLVWAVLMKRQKMSLFFWQHGEENMAKALVACKL 748
Query: 1909 YKATAKIAEDEYLDVEEAKRLFDNAVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGN 2088
Y++ A+ + + ++ L + + + A++LL+Q +R D ++LL EL +W N
Sbjct: 749 YRSMGYEAKKSDVVDDASEELKEYSNEFGTLAVDLLEQSFRQDETMAMKLLTYELKNWSN 808
Query: 2089 NNCLSLAVLANTKTFLAHPCCQILLAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKP 2268
+ CL LAV ++ + F+AH C Q+LL+++W G L +R S +V+ +++ PPAIL + YK
Sbjct: 809 STCLKLAVSSHLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKS 868
Query: 2269 KHSKTARLLSEETPEQLPYPRESITSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISS 2448
K ++ A + + Q+ T S S + Q + E S+
Sbjct: 869 K-AEMAHIPQSQDDHQM-------TMEDSENNFQSGADDIQMDVFKESRSHDH-----ME 915
Query: 2449 RKNXXXXXXXXXXXXXXFKREPQLNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILL 2628
KN R +L + AFY +PI KFWS + +L FL + ++L
Sbjct: 916 AKNEAETQF----------RSRKLPLTRKIYAFYRAPIVKFWSNTLFYLGFLMLYSYVVL 965
Query: 2629 LETSLKPSKYEWITFIYTVTLSVEHIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFF 2808
++ +PS EW+ +Y T ++E IR++ SE +I++K+KV++++++NI A++ F
Sbjct: 966 VKMPEQPSPQEWVVILYIFTSAIEKIREMFMSEAGKISQKIKVWFSEYFNICDFLAIITF 1025
Query: 2809 LVGYGFRLVPMYRHSWGRVLLSFSNVLFYMKIFEYLSVHPLLGPYIQMAAKMVW------ 2970
+G+G RL + GR++ + + +Y+++ + L+V+ GPY+ M AKMV
Sbjct: 1026 FIGFGLRLAGGEVFTPGRLVYCLNIIFWYVRLMDILAVNQQAGPYVMMIAKMVLEAIFTS 1085
Query: 2971 --------SMCYICVLLLVPLMAFGVNRQALTEPNVKDWHWLLVRNIFYKPYFMLYGEVY 3126
+M YI V++ + L++FGV R+A+ P+ ++ W L +++ ++PY+M+YGEVY
Sbjct: 1086 HRHLFQVANMFYIVVIMAIVLLSFGVPRKAILYPD-EEPSWTLAKDVIFQPYWMMYGEVY 1144
Query: 3127 AGEIDTCGD-----EGIRCFPGYFIPPLLMXXXXXXXXXXXXXXXXXXXXXXYNDSIEKS 3291
A EID C + C G F+ PLL Y S
Sbjct: 1145 AYEIDVCANNTEPLSKQLCATGVFLTPLLQAVYLFVQYILMVNLLIAFFNNVYLQVKSIS 1204
Query: 3292 KEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDYLYNLRRPDT-KRFRSEHSI---- 3456
+W +QRY +M YH+ P LPPP + HVY ++ T +E +
Sbjct: 1205 NLVWKYQRYHFIMVYHEKPVLPPPVILLCHVYSLFCMCRKRKKESTYGPSMAEDQVSPPE 1264
Query: 3457 ---------------KLSVTEDEMKRIQDFEEDCIDTLTRIR--KLKLNTKEPLSVT-DL 3582
+L +TE++ K++ DFEE C++ + + ++E + VT +
Sbjct: 1265 PKPTTPLINALLFLPELFLTEEDRKKLHDFEEQCVEAYFHEKDDQFHSGSEERIRVTSER 1324
Query: 3583 TELTCQRVHDLMQENFLLKSRVYDIETKIDHISNSSDEVVQILKNKKLSQNFAASSL 3753
E C ++ ++ + +K ++ ++++I H+ + S V LK + AS +
Sbjct: 1325 VESMCMQLREVGNKVTFIKRSLHALDSQIGHLQDLSVLTVDTLKTLTAQRASEASKV 1381
>gi|28274684|ref|NP_066003.1| transient receptor potential cation
channel, subfamily M, member 3 isoform a; melastatin 2;
long transient receptor potential channel 3 [Homo
sapiens]
gi|27597205|dbj|BAC55102.1| hypothetical protein [Homo sapiens]
gi|28626247|gb|AAO49153.1| calcium-permeable store-operated channel
TRPM3a [Homo sapiens]
Length = 1554
Score = 684 bits (1765), Expect = 0.0
Identities = 396/1130 (35%), Positives = 638/1130 (56%), Gaps = 30/1130 (2%)
Frame = +1
Query: 385 YVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTT 564
YVR+S+D++P +++LM K W LE P+L+I+VHGG+ NFEL+ +L ++F KG++KAA TT
Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Query: 565 GAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYY 744
GAWI T G+++GV+RHV AL + +++ R +I TIGIAPWG+++ +E LI ++ Y
Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDH--ASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPY 119
Query: 745 DVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCN---GRKVP 915
S ++ + +LN HS+F+LADNGT G++GA++ LR+ LE HI+ N G+ VP
Sbjct: 120 QTMSNPMS-KLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVP 178
Query: 916 VVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFAAEVGE 1095
VV ++EGG + I+ + +Y+ P +P +VCDGSGRA+DI++F +Y G + +
Sbjct: 179 VVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRD 238
Query: 1096 KLRNLIKMVFP--ETDQEEMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQN 1269
+L I+ F T + +F + EC+ + +L+ +FR G E +D+D IL+ +L+ N
Sbjct: 239 QLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGAN 298
Query: 1270 LPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENGVS 1449
+QL+L L+WNRVD+A+S +F G++W LE+AM DAL DRVDFV+ L+ENGVS
Sbjct: 299 ASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVS 358
Query: 1450 MKNFLSINRLENLYNMDDINSA---HSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNA 1620
M FL+I+RLE LYN S H VR+ + ++ P +++ IG V+E LMG A
Sbjct: 359 MHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKG--NLPPDYRISLIDIGLVIEYLMGGA 416
Query: 1621 FQLYYTSRSFKGKYDRY---KRINQSSYFHRKRKIV----QKELFKKKSDDQINDNEEED 1779
++ YT + F+ Y KR + I +K K++ + I+ ++ E
Sbjct: 417 YRCNYTRKRFRTLYHNLFGPKRPKALKLLGMEDDIPLRRGRKTTKKREEEVDIDLDDPEI 476
Query: 1780 FSFAYPFNDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEE 1959
F +PF++L++WAVL R MA W HGE+AMAK L+A +L KA A A + + +
Sbjct: 477 NHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDI 536
Query: 1960 AKRLFDNAVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLA 2139
++ L N+ + A+ELLDQ Y+ D ++LL EL +W N CL LAV A + F+A
Sbjct: 537 SQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIA 596
Query: 2140 HPCCQILLAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQL 2319
H C Q+LL ++W G L++R S ++V+ ++ PP+IL + +K K + +
Sbjct: 597 HTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNK-------------DDM 643
Query: 2320 PYPRESITSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKNXXXXXXXXXXXXXX 2499
PY S + K EE ++ EK ++T + R N
Sbjct: 644 PY-----MSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQS 698
Query: 2500 FKREPQLNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIY 2679
R L + + FY++PI KFW + +A++ +L I+L++ PS EWI Y
Sbjct: 699 KHRLIPLGR--KIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISY 756
Query: 2680 TVTLSVEHIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSWG 2859
TL +E +R+++ SE ++ +KVKV+ +++N+ A+L F VG RL S G
Sbjct: 757 IFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDG 816
Query: 2860 RVLLSFSNVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQAL 3039
RV+ + + +Y+++ + V+ LGPY+ M KM+ M Y +++LV LM+FGV RQA+
Sbjct: 817 RVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAI 876
Query: 3040 TEPNVKDWHWLLVRNIFYKPYFMLYGEVYAGEID-TCGDEGIR----------CFPGYFI 3186
PN ++ W L +NIFY PY+M+YGEV+A +ID CG R C G +I
Sbjct: 877 LFPN-EEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWI 935
Query: 3187 PPLLMXXXXXXXXXXXXXXXXXXXXXXYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPF 3366
P +M + + S ++W FQRYQ +M +H+ P LPPP
Sbjct: 936 VPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPL 995
Query: 3367 SIFAHVYHFIDYL-YNLRRPDTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTLTRIRKL 3543
IF+H+ +L R+ ++ ++ +KL +T+DE+K++ DFEE CI+ R +
Sbjct: 996 IIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDD 1055
Query: 3544 KLNTK--EPLSVT-DLTELTCQRVHDLMQENFLLKSRVYDIETKIDHISN 3684
+ N+ E + VT + E R+ ++ + +K+ + ++ ++ + +
Sbjct: 1056 RFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLED 1105
>gi|45935358|ref|NP_079247.3| transient receptor potential cation
channel, subfamily M, member 3 isoform b; melastatin 2;
long transient receptor potential channel 3 [Homo
sapiens]
gi|28626249|gb|AAO49154.1| calcium-permeable store-operated channel
TRPM3b [Homo sapiens]
Length = 1566
Score = 683 bits (1763), Expect = 0.0
Identities = 397/1140 (34%), Positives = 639/1140 (55%), Gaps = 40/1140 (3%)
Frame = +1
Query: 385 YVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTT 564
YVR+S+D++P +++LM K W LE P+L+I+VHGG+ NFEL+ +L ++F KG++KAA TT
Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Query: 565 GAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYY 744
GAWI T G+++GV+RHV AL + +++ R +I TIGIAPWG+++ +E LI ++ Y
Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDH--ASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPY 119
Query: 745 DVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCN---GRKVP 915
S ++ + +LN HS+F+LADNGT G++GA++ LR+ LE HI+ N G+ VP
Sbjct: 120 QTMSNPMS-KLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVP 178
Query: 916 VVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFAAEVGE 1095
VV ++EGG + I+ + +Y+ P +P +VCDGSGRA+DI++F +Y G + +
Sbjct: 179 VVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRD 238
Query: 1096 KLRNLIKMVFP--ETDQEEMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQN 1269
+L I+ F T + +F + EC+ + +L+ +FR G E +D+D IL+ +L+ N
Sbjct: 239 QLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGAN 298
Query: 1270 LPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENGVS 1449
+QL+L L+WNRVD+A+S +F G++W LE+AM DAL DRVDFV+ L+ENGVS
Sbjct: 299 ASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVS 358
Query: 1450 MKNFLSINRLENLYNMDDINSA---HSVRN----------WMENFDSMDPHTYLTIPMIG 1590
M FL+I+RLE LYN S H VR+ W+ ++ P +++ IG
Sbjct: 359 MHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKREYPGFGWIYFKGNLPPDYRISLIDIG 418
Query: 1591 QVVEKLMGNAFQLYYTSRSFKGKYDRY---KRINQSSYFHRKRKIV----QKELFKKKSD 1749
V+E LMG A++ YT + F+ Y KR + I +K K++ +
Sbjct: 419 LVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGMEDDIPLRRGRKTTKKREEE 478
Query: 1750 DQINDNEEEDFSFAYPFNDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKI 1929
I+ ++ E F +PF++L++WAVL R MA W HGE+AMAK L+A +L KA A
Sbjct: 479 VDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHE 538
Query: 1930 AEDEYLDVEEAKRLFDNAVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLA 2109
A + + + ++ L N+ + A+ELLDQ Y+ D ++LL EL +W N CL LA
Sbjct: 539 ASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLA 598
Query: 2110 VLANTKTFLAHPCCQILLAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTAR 2289
V A + F+AH C Q+LL ++W G L++R S ++V+ ++ PP+IL + +K K
Sbjct: 599 VAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNK------ 652
Query: 2290 LLSEETPEQLPYPRESITSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKNXXXX 2469
+ +PY S + K EE ++ EK ++T + R N
Sbjct: 653 -------DDMPY-----MSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESS 700
Query: 2470 XXXXXXXXXXFKREPQLNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKP 2649
R L + + FY++PI KFW + +A++ +L I+L++ P
Sbjct: 701 RKKDEEEVQSKHRLIPLGR--KIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWP 758
Query: 2650 SKYEWITFIYTVTLSVEHIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFR 2829
S EWI Y TL +E +R+++ SE ++ +KVKV+ +++N+ A+L F VG R
Sbjct: 759 STQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILR 818
Query: 2830 LVPMYRHSWGRVLLSFSNVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPL 3009
L S GRV+ + + +Y+++ + V+ LGPY+ M KM+ M Y +++LV L
Sbjct: 819 LQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVL 878
Query: 3010 MAFGVNRQALTEPNVKDWHWLLVRNIFYKPYFMLYGEVYAGEID-TCGDEGIR------- 3165
M+FGV RQA+ PN ++ W L +NIFY PY+M+YGEV+A +ID CG R
Sbjct: 879 MSFGVARQAILFPN-EEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQ 937
Query: 3166 ---CFPGYFIPPLLMXXXXXXXXXXXXXXXXXXXXXXYNDSIEKSKEIWLFQRYQQLMEY 3336
C G +I P +M + + S ++W FQRYQ +M +
Sbjct: 938 LPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTF 997
Query: 3337 HDSPFLPPPFSIFAHVYHFIDYL-YNLRRPDTKRFRSEHSIKLSVTEDEMKRIQDFEEDC 3513
H+ P LPPP IF+H+ +L R+ ++ ++ +KL +T+DE+K++ DFEE C
Sbjct: 998 HERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQC 1057
Query: 3514 IDTLTRIRKLKLNTK--EPLSVT-DLTELTCQRVHDLMQENFLLKSRVYDIETKIDHISN 3684
I+ R + + N+ E + VT + E R+ ++ + +K+ + ++ ++ + +
Sbjct: 1058 IEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLED 1117
>gi|34861963|ref|XP_219747.2| similar to transient receptor potential
cation channel 6/channel-kinase 2 [Rattus norvegicus]
Length = 1974
Score = 681 bits (1756), Expect = 0.0
Identities = 392/1169 (33%), Positives = 652/1169 (55%), Gaps = 40/1169 (3%)
Frame = +1
Query: 133 WIENTFEKRECIRFAALPKDPERCGCGRPLSAHTPASTFFSTLPVHLLEKEQQTWTIANN 312
WIE F KREC +F KDP RC CGR + H +S EQ W++ +
Sbjct: 30 WIERVFYKRECNKFIPSSKDPHRCYCGRLIQEHQGLDRAWSLSATEGNGNEQ--WSVEKH 87
Query: 313 TQTSTTDAFGTIVFQGGAHAHKAQYVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGM 492
T S TD FGTI FQ G H + ++Y+R S+D++ +++LM K W +E P+LVI+VHGG+
Sbjct: 88 TVKSPTDTFGTINFQDGEHIYHSKYIRTSWDTKSDHLLHLMLKEWNMELPKLVISVHGGL 147
Query: 493 SNFELEERLGRLFRKGMLKAAQTTGAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVT 672
NF++ +L F +G++KAA+TTGAWIIT G++SGV +HV AL +A S +R +I T
Sbjct: 148 QNFKMPSKLKETFSQGLVKAAETTGAWIITEGINSGVSKHVGDAL-KAHSSMSLR-KIWT 205
Query: 673 IGIAPWGVIKRKERLIRQNEHVYYDVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADL 852
+GI PWGVI+ + L+ ++ Y S ++ + LN HS+F+L D+GTVG++G +
Sbjct: 206 VGIPPWGVIENQRELVGKDVVCMYQTLSNPLS-KLTTLNCMHSHFILCDDGTVGKYGNEE 264
Query: 853 HLRQNLENHIAT---FGCNGRKVPVVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGR 1023
LR+NLE H++ C+ + VPVV ++EGG + I + + V K P +VC+G+GR
Sbjct: 265 KLRRNLEKHLSMQKIHTCSRQGVPVVGLVVEGGPNVILWVWETVRNKE--PVVVCEGTGR 322
Query: 1024 AADIISFAARYINSDGTFAAEVGEKLRNLIKMVFPET--DQEEMFRKITECVIRDDLLRI 1197
AAD+++F ++ G +V E++ LI+ +F + + +F+ + EC++ D + I
Sbjct: 323 AADLLAFTYKHSEDGGILRPQVKEEILCLIQNMFNFSLRQSKHLFQILMECMVHKDSITI 382
Query: 1198 FRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVLE 1377
F EE +D+D IL +L+ +L EQL L ++W+R+D+AK + G+ W LE
Sbjct: 383 FDADSEEHQDLDLAILKALLKGTSLSISEQLNLAMAWDRMDIAKKHILIYGQHWKPGALE 442
Query: 1378 KAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLYNMDDINSAHSVRNWMENFDSMD 1557
+AM DAL DRVDFV+ L+ENGV++ FL+I+RLE+LYN + +R+ +++ +
Sbjct: 443 QAMRDALVMDRVDFVKLLIENGVNLHRFLTISRLEDLYNTKQGPTNKFLRHLVQD---VK 499
Query: 1558 PHTYL-----TIPMIGQVVEKLMGNAFQLYYTSRSFKGKY-DRYKR----INQSSYFHRK 1707
HT L T+ IG V+E L+G A++ YT +SF+ Y D Y++ ++Q +
Sbjct: 500 QHTLLSSYRITLIDIGLVIEYLIGGAYRSSYTRKSFRVLYNDLYRKHKHPLHQRHSLGNR 559
Query: 1708 RKIVQKELF----------------------KKKSDDQINDNEEEDFS-FAYPFNDLLIW 1818
++ + L KKKS ++ + +E+ + F YP+NDLL+W
Sbjct: 560 KESSESTLHSQFFRTAQPYKSKDKPEDSHKPKKKSKERHSLSEDPGSAGFIYPYNDLLVW 619
Query: 1819 AVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEEAKRLFDNAVKCRE 1998
AVL R MA W HGE+A K ++A LY+A A+ A++ + + ++ L + + +
Sbjct: 620 AVLMKRQKMAMFFWQHGEEATVKAVIASILYRAMAREAKESNMVDDTSEELKKYSEQFGQ 679
Query: 1999 DAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPCCQILLAELWH 2178
A+++L++ ++ + ++LL EL +W N+ CL LAV + F++H C Q+LL ++W
Sbjct: 680 LALDVLEKAFKQNEPMAMKLLTYELKNWSNSTCLKLAVSGGLRPFVSHSCTQMLLTDMWM 739
Query: 2179 GSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQLPYPRESITSTTSN 2358
G LK+R S ++++ +++ PP IL + +K K + S++ Y + +++T
Sbjct: 740 GRLKMRKNSWLKIIISILLPPMILTLEFKSKAEMSHVPQSQDFQFTWNYSDQGLSNTKEA 799
Query: 2359 R-YRYSKGPEEQKETLLEKGSYTKKVTIISSRKNXXXXXXXXXXXXXXFKREPQ-LNKFE 2532
+ Y +GP+E+ + L + PQ L
Sbjct: 800 KDYDLERGPDEKLDEALH----------------------------LDLRNVPQSLPWTR 831
Query: 2533 RFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIYTVTLSVEHIRK 2712
R FYS+P KFW + +A+L FL T +L+E +PS EW+ IY T ++E +R+
Sbjct: 832 RVYEFYSAPFVKFWFYTMAYLAFLMLFTYTVLVEMQPQPSVQEWLVIIYIFTNAIEKVRE 891
Query: 2713 LMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSWGRVLLSFSNVLF 2892
+ SE S+ +KVK++ ++++N+ + A+ F VG+G R H+ GR++ + +
Sbjct: 892 ICISEPSKFTQKVKMWLSEYWNLMETVAIGLFAVGFGLRWGHPPLHTAGRLIYCIDIIFW 951
Query: 2893 YMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEPNVKDWHWL 3072
+ ++ ++ +V+ GPY+ M AKM +M YI +++ + L++FGV R+A+ P + W
Sbjct: 952 FSRLLDFFAVNQHAGPYVTMIAKMAANMFYIVIIMAIVLLSFGVARKAILSPK-EPPSWR 1010
Query: 3073 LVRNIFYKPYFMLYGEVYAGEIDTCGDEGIRCFPGYFIPPLLMXXXXXXXXXXXXXXXXX 3252
L R+I ++PY+M+YGEVYA EID C +E C PG F+ P L
Sbjct: 1011 LARDIVFEPYWMMYGEVYASEIDVCSNE-TSCPPGSFLTPFLQAVYLFVQYIIMVNLLIA 1069
Query: 3253 XXXXXYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDYLYNLRRPDTK 3432
Y D S ++W + RY+ +M YH P+LPPPF + +H+ + L P +
Sbjct: 1070 CFNNIYLDIKSISNKLWKYNRYRYIMTYHQKPWLPPPFILISHLCLLLRGLCCRPAPQDQ 1129
Query: 3433 RFRSEHSIKLSVTEDEMKRIQDFEEDCID 3519
+ +KL +T+D++K++ DFEE C++
Sbjct: 1130 E-EGDMGLKLYLTKDDLKKLHDFEEQCVE 1157
>gi|28626251|gb|AAO49155.1| calcium-permeable store-operated channel
TRPM3c [Homo sapiens]
Length = 1566
Score = 679 bits (1753), Expect = 0.0
Identities = 396/1142 (34%), Positives = 638/1142 (55%), Gaps = 42/1142 (3%)
Frame = +1
Query: 385 YVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTT 564
YVR+S+D++P +++LM K W LE P+L+I+VHGG+ NFEL+ +L ++F KG++KAA TT
Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Query: 565 GAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYY 744
GAWI T G+++GV+RHV AL + +++ R +I TIGIAPWG+++ +E LI ++ Y
Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDH--ASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPY 119
Query: 745 DVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCN---GRKVP 915
S ++ + +LN HS+F+LADNGT G++GA++ LR+ LE HI+ N G+ VP
Sbjct: 120 QTMSNPMS-KLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVP 178
Query: 916 VVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFAAEVGE 1095
VV ++EGG + I+ + +Y+ P +P +VCDGSGRA+DI++F +Y G + +
Sbjct: 179 VVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRD 238
Query: 1096 KLRNLIKMVFP--ETDQEEMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQN 1269
+L I+ F T + +F + EC+ + +L+ +FR G E +D+D IL+ +L+ N
Sbjct: 239 QLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGAN 298
Query: 1270 LPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENGVS 1449
+QL+L L+WNRVD+A+S +F G++W LE+AM DAL DRVDFV+ L+ENGVS
Sbjct: 299 ASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVS 358
Query: 1450 MKNFLSINRLENLYNMDDINSA---HSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNA 1620
M FL+I+RLE LYN S H VR+ + ++ P +++ IG V+E LMG A
Sbjct: 359 MHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKG--NLPPDYRISLIDIGLVIEYLMGGA 416
Query: 1621 FQLYYTSRSFKGKYDRY---KRINQSSYFHRKRKIV----QKELFKKKSDDQINDNEEED 1779
++ YT + F+ Y KR + I +K K++ + I+ ++ E
Sbjct: 417 YRCNYTRKRFRTLYHNLFGPKRPKALKLLGMEDDIPLRRGRKTTKKREEEVDIDLDDPEI 476
Query: 1780 FSFAYPFNDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEE 1959
F +PF++L++WAVL R MA W HGE+AMAK L+A +L KA A A + + +
Sbjct: 477 NHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDI 536
Query: 1960 AKRLFDNAVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLA 2139
++ L N+ + A+ELLDQ Y+ D ++LL EL +W N CL LAV A + F+A
Sbjct: 537 SQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIA 596
Query: 2140 HPCCQILLAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQL 2319
H C Q+LL ++W G L++R S ++V+ ++ PP+IL + +K K + +
Sbjct: 597 HTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNK-------------DDM 643
Query: 2320 PYPRESITSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKNXXXXXXXXXXXXXX 2499
PY S + K EE ++ EK ++T + R N
Sbjct: 644 PY-----MSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQS 698
Query: 2500 FKREPQLNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIY 2679
R L + + FY++PI KFW + +A++ +L I+L++ PS EWI Y
Sbjct: 699 KHRLIPLGR--KIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISY 756
Query: 2680 TVTLSVEHIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSWG 2859
TL +E +R+++ SE ++ +KVKV+ +++N+ A+L F VG RL S G
Sbjct: 757 IFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDG 816
Query: 2860 RVLLSFSNVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQAL 3039
RV+ + + +Y+++ + V+ LGPY+ M KM+ M Y +++LV LM+FGV RQA+
Sbjct: 817 RVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAI 876
Query: 3040 TEPNVKDWHWLLVRNIFYKPYFMLYGEVYAGEID-------------TCGDEGIR----- 3165
PN ++ W L +NIFY PY+M+YGEV+A +ID CG R
Sbjct: 877 LFPN-EEPSWKLAKNIFYMPYWMIYGEVFADQIDRKQVYDSHTPKSAPCGQNETREDGKI 935
Query: 3166 -----CFPGYFIPPLLMXXXXXXXXXXXXXXXXXXXXXXYNDSIEKSKEIWLFQRYQQLM 3330
C G +I P +M + + S ++W FQRYQ +M
Sbjct: 936 IQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIM 995
Query: 3331 EYHDSPFLPPPFSIFAHVYHFIDYL-YNLRRPDTKRFRSEHSIKLSVTEDEMKRIQDFEE 3507
+H+ P LPPP IF+H+ +L R+ ++ ++ +KL +T+DE+K++ DFEE
Sbjct: 996 TFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEE 1055
Query: 3508 DCIDTLTRIRKLKLNTK--EPLSVT-DLTELTCQRVHDLMQENFLLKSRVYDIETKIDHI 3678
CI+ R + + N+ E + VT + E R+ ++ + +K+ + ++ ++ +
Sbjct: 1056 QCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQL 1115
Query: 3679 SN 3684
+
Sbjct: 1116 ED 1117
>gi|24653815|ref|NP_725447.1| CG30078-PB [Drosophila melanogaster]
gi|21627149|gb|AAM68528.1| CG30078-PB [Drosophila melanogaster]
Length = 1078
Score = 678 bits (1750), Expect = 0.0
Identities = 404/1055 (38%), Positives = 598/1055 (56%), Gaps = 32/1055 (3%)
Frame = +1
Query: 133 WIENTFEKRECIRFAALPKDPERCGCGRPLSAHTPASTFFSTLPVHLLEKEQQTWTIANN 312
WIE F+KRECI+F PKD +C CG+ H S P L W +
Sbjct: 15 WIETNFQKRECIKFIPCPKDDTKCCCGQAQITHQTIPGIESGSPGDL-------WLPTKH 67
Query: 313 TQTSTTDAFGTIVFQGGAHAHKAQYVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGM 492
T+ TDA+GTI FQGGAH KAQYVRLS+D+ P ++ L K W LE P+L+ITV GG
Sbjct: 68 TRPQPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEWNLELPKLLITVQGGK 127
Query: 493 SNFELEERLGRLFRKGMLKAAQTTGAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVT 672
+NF+L+ +L + RKG+LKAA+TTGAWI T G ++GV + V AL G + ++V+
Sbjct: 128 ANFDLQAKLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDALLLEG--QQRTGRVVS 185
Query: 673 IGIAPWGVIKRKERLIRQNEHVYYDVHSLSV-NANVGILNDRHSYFLLADNGTVGRFGAD 849
IGIAPWG+++R L+ N V HS+S + + +LN+RH+YFLL DNGT ++GA+
Sbjct: 186 IGIAPWGIVERNHELLGHNREV--PCHSISSPRSKLAVLNNRHAYFLLVDNGTQAKYGAE 243
Query: 850 LHLRQNLENHIATFGCNG---RKVPVVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSG 1020
L LR+ LE I+ + PVVC ++EGG ++I A+ +YVT P +P +VCDGSG
Sbjct: 244 LILRRKLEKFISNLKLHPFTHSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSG 303
Query: 1021 RAADIISFAARYINSDGTFAAEVGEKLRNLIKMVFPET------DQEEMFRKITECVIRD 1182
RAAD+++F +Y SDG V E +R+ + +T E++++++ +C
Sbjct: 304 RAADLLAFVHKYA-SDGE-EQPVLESMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRNK 361
Query: 1183 DLLRIFRYGQEEE---EDVDFVILSTVLQKQNLPPDEQLALTLSWNRVDLAKSCLFSNGR 1353
+L+ +FR ++ E +++D IL+ + + Q+L P EQL+L L+WNRVD+A+S +F G+
Sbjct: 362 NLITVFRIQEKPEGEAQELDQTILTALFKSQHLSPPEQLSLALTWNRVDIARSEIFVYGQ 421
Query: 1354 KWSSDVLEKAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLYNMDDINSAHSVRNW 1533
+W + L++AM AL DR+DFV+ LLENGVSMK FL+I RLE LYN A+++
Sbjct: 422 EWPNGALDEAMMQALEHDRIDFVKLLLENGVSMKKFLTIPRLEELYNTKH-GPANTLGYI 480
Query: 1534 MENFDSMDPHTYL-TIPMIGQVVEKLMGNAFQLYYTSRSFKGKYDRYKRINQSSYFHRKR 1710
+ + P Y+ T+ IG V+ KLMG A++ YYT R F+ Y K +N + RK
Sbjct: 481 LRDVRPHIPKGYIYTLHDIGLVINKLMGGAYRSYYTRRKFRPIYA--KVMNSYANACRKS 538
Query: 1711 KIVQKELFKKKSDDQINDN----EEEDFSFAYPFNDLLIWAVLTSRHGMAECMWVHGEDA 1878
Q + + + + E F +PFN+LLIWAVLT R MA MW HGE+A
Sbjct: 539 STYQYQRYAGANSLSLVTGLLPFTSEMALFEFPFNELLIWAVLTKRQQMALLMWTHGEEA 598
Query: 1879 MAKCLLAIRLYKATAKIAEDEYLDVEEAKRLFDNAVKCREDAIELLDQCYRADHDRTLRL 2058
+AK L++ +LYKA A A ++ LD E + L A + +LLD YR D ++ RL
Sbjct: 599 LAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLDFSYRQDAEKAQRL 658
Query: 2059 LRMELPHWGNNNCLSLAVLANTKTFLAHPCCQILLAELWHGSLKVRSGSNVRVLTALICP 2238
L EL W N +CLSLAV AN + LAHPC Q++LA+LW G L+ R +N +V+ L P
Sbjct: 659 LTCELHSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVILGLAMP 718
Query: 2239 PAILFMAYKPKHSKTARLLSEETPEQLPYPRESITSTTSNRYRYSKGPEEQKETLLEKGS 2418
I + +K S+E +Q+P E + S + E LL +
Sbjct: 719 FYIRQLDFK----------SKEELQQMPQTEEEHLENQNLDNDDSDRSQPDAEALL-ADT 767
Query: 2419 YTKKVTIISSRKNXXXXXXXXXXXXXXF--------KREPQLNKFERFRAFYSSPITKFW 2574
Y+ + T + F K+ L ++F FY++PITKFW
Sbjct: 768 YSVRDTKVHENGKVSLTDSDTAQFREFFNLSEYNEVKQHQPLRLKKKFYEFYTAPITKFW 827
Query: 2575 SWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIYTVTLSVEHIRKLMTSEGSRINEKVK 2754
+ IA++ FL + +L++ P EW + Y TL E +R++++SE I K
Sbjct: 828 ADSIAYMFFLIMFSFTVLVKMEQMPRWQEWYSIAYITTLGFEKVREIISSEPVAITHKFS 887
Query: 2755 VFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSW---GRVLLSFSNVLFYMKIFEYLSVH 2925
V+ +N AA++ F++G FR +R + GRV+ ++ +Y++I L V+
Sbjct: 888 VWAWNMWNPCDGAAIILFVIGLAFR----FRENTMDIGRVIYCVDSIYWYLRILNILGVN 943
Query: 2926 PLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEPNVKDWHWLLVRNIFYKPYF 3105
LGP + M KMV +M Y VLL V LM+FGV+RQA+ PN K W L++ + ++PYF
Sbjct: 944 KYLGPLVTMMGKMVKNMIYFVVLLAVVLMSFGVSRQAILYPN-KQPTWSLIKEVTFQPYF 1002
Query: 3106 MLYGEVYAGEID-TCGDEGIR--CFPGYFIPPLLM 3201
MLYGEV+AG+ID CG++ + C G+++ P+ M
Sbjct: 1003 MLYGEVFAGDIDPPCGEDPSQPGCVTGHWVTPITM 1037
>gi|37790764|gb|AAR03488.1| transient receptor potential cation
channel subfamily M member 6 variant b [Homo sapiens]
Length = 2017
Score = 678 bits (1750), Expect = 0.0
Identities = 403/1254 (32%), Positives = 681/1254 (54%), Gaps = 52/1254 (4%)
Frame = +1
Query: 109 LTEKLSPPWIENTFEKRECIRFAALPKDPERCG-------------CGRPLSAHTPASTF 249
+ K WI+ F+KREC K+P RC CGR + H A
Sbjct: 3 ILSKSQKSWIKGVFDKRECSTIIPSSKNPHRCTPVCQVCQNLIRCYCGRLIGDH--AGID 60
Query: 250 FSTLPVHLLEKEQQTWTIANNTQTSTTDAFGTIVFQGGAHAHKAQYVRLSYDSEPLDVMY 429
+S KE + W++ +T S TD FGTI FQ G H H A+Y+R SYD++ +++
Sbjct: 61 YSWTISAAKGKESEQWSVEKHTTKSPTDTFGTINFQDGEHTHHAKYIRTSYDTKLDHLLH 120
Query: 430 LMEKVWGLEAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTTGAWIITSGLDSGVVR 609
LM K W +E P+LVI+VHGG+ NF + + +F +G++KAA+TTGAWIIT G+++GV +
Sbjct: 121 LMLKEWKMELPKLVISVHGGIQNFTMPSKFKEIFSQGLVKAAETTGAWIITEGINTGVSK 180
Query: 610 HVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYYDVHSLSVNANVGILN 789
HV AL S+ +I T+GI PWGVI+ + LI ++ Y ++ + LN
Sbjct: 181 HVGDALKSH--SSHSLRKIWTVGIPPWGVIENQRDLIGKDVVCLYQTLDNPLS-KLTTLN 237
Query: 790 DRHSYFLLADNGTVGRFGADLHLRQNLENHIAT--FGCNGRK-VPVVCTLLEGGISSINA 960
HS+F+L+D+GTVG++G ++ LR+NLE +++ C R+ VPVV ++EGG + I +
Sbjct: 238 SMHSHFILSDDGTVGKYGNEMKLRRNLEKYLSLQKIHCRSRQGVPVVGLVVEGGPNVILS 297
Query: 961 IHDYVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFAAEVGEKLRNLIKMVFPET-- 1134
+ + T+K P +VC+G+GRAAD+++F +++ +G +V E++ +I+ F +
Sbjct: 298 VWE--TVKDKDPVVVCEGTGRAADLLAFTHKHLADEGMLRPQVKEEIICMIQNTFNFSLK 355
Query: 1135 DQEEMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWNR 1314
+ +F+ + EC++ D + IF EE++D+D IL+ +L+ NL EQL L ++W+R
Sbjct: 356 QSKHLFQILMECMVHRDCITIFDADSEEQQDLDLAILTALLKGTNLSASEQLNLAMAWDR 415
Query: 1315 VDLAKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLYN 1494
VD+AK + + W D LE+AM+DAL DRVDFV+ L+E GV++ FL+I RLE LYN
Sbjct: 416 VDIAKKHILIYEQHWKPDALEQAMSDALVMDRVDFVKLLIEYGVNLHRFLTIPRLEELYN 475
Query: 1495 MDDINSAHSVRNWMENFDSMDPHTYL-----TIPMIGQVVEKLMGNAFQLYYTSRSFKGK 1659
+ + + +++ + HT L T+ IG VVE L+G A++ YT + F+
Sbjct: 476 TKQGPTNTLLHHLVQD---VKQHTLLSGYRITLIDIGLVVEYLIGRAYRSNYTRKHFRAL 532
Query: 1660 YD----RYKRINQSS---------------------YFHRKRKIVQKELFKKKSDDQIND 1764
Y+ +YK SS Y +++ IV + KK + ++D
Sbjct: 533 YNNLYRKYKHQRHSSGNRNESAESTLHSQFIRTAQPYKFKEKSIVLHKSRKKSKEQNVSD 592
Query: 1765 NEEEDFSFAYPFNDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEY 1944
+ E F YP+NDLL+WAVL R MA W HGE+A K ++A LY+A A A++ +
Sbjct: 593 DPEST-GFLYPYNDLLVWAVLMKRQKMAMFFWQHGEEATVKAVIACILYRAMAHEAKESH 651
Query: 1945 LDVEEAKRLFDNAVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANT 2124
+ + ++ L + + + + A++LL++ ++ + + LL EL +W N+ CL LAV
Sbjct: 652 MVDDASEELKNYSKQFGQLALDLLEKAFKQNERMAMTLLTYELRNWSNSTCLKLAVSGGL 711
Query: 2125 KTFLAHPCCQILLAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEE 2304
+ F++H C Q+LL ++W G LK+R S ++++ ++I PP IL + +K K + S++
Sbjct: 712 RPFVSHTCTQMLLTDMWMGRLKMRKNSWLKIIISIILPPTILTLEFKSKAEMSHVPQSQD 771
Query: 2305 TPEQLPYPRESITSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKNXXXXXXXXX 2484
Y ++ +S SK KE LE+G K + ++
Sbjct: 772 FQFMWYYSDQNASS--------SKESASVKEYDLERGHDEK----LDENQHFGLESG--- 816
Query: 2485 XXXXXFKREPQLNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEW 2664
L + FYS+PI KFW + +A+L FL T +L+E +PS EW
Sbjct: 817 --------HQHLPWTRKVYEFYSAPIVKFWFYTMAYLAFLMLFTYTVLVEMQPQPSVQEW 868
Query: 2665 ITFIYTVTLSVEHIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMY 2844
+ IY T ++E +R++ SE + +KVKV+ ++++N+ + A+ F G+ R
Sbjct: 869 LVSIYIFTNAIEVVREICISEPGKFTQKVKVWISEYWNLTETVAIGLFSAGFVLRWGDPP 928
Query: 2845 RHSWGRVLLSFSNVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGV 3024
H+ GR++ + ++ ++ ++ +V+ GPY+ M AKM +M YI +++ + L++FGV
Sbjct: 929 FHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMTANMFYIVIIMAIVLLSFGV 988
Query: 3025 NRQALTEPNVKDWHWLLVRNIFYKPYFMLYGEVYAGEIDTCGDEGIRCFPGYFIPPLLMX 3204
R+A+ P + W L R+I ++PY+M+YGEVYAGEID C + C PG F+ P L
Sbjct: 989 ARKAILSPK-EPPSWSLARDIVFEPYWMIYGEVYAGEIDVCSSQP-SCPPGSFLTPFLQA 1046
Query: 3205 XXXXXXXXXXXXXXXXXXXXXYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHV 3384
Y D S +W + RY+ +M YH+ P+LPPP + +HV
Sbjct: 1047 VYLFVQYIIMVNLLIAFFNNVYLDMESISNNLWKYNRYRYIMTYHEKPWLPPPLILLSHV 1106
Query: 3385 YHFIDYLYNLRRPDTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTL--TRIRKLKLNTK 3558
+ L R P + + +KL ++++++K++ DFEE C++ ++ + + +
Sbjct: 1107 GLLLRRLCCHRAPHDQE-EGDVGLKLYLSKEDLKKLHDFEEQCVEKYFHEKMEDVNCSCE 1165
Query: 3559 EPLSVTD--LTELTCQRVHDLMQENFLLKSRVYDIETKIDHISNSSDEVVQILK 3714
E + VT +TE+ Q + ++ ++ +K + +++++ H+ + S V LK
Sbjct: 1166 ERIRVTSERVTEMYFQ-LKEMNEKVSFIKDSLLSLDSQVGHLQDLSALTVDTLK 1218
>gi|18921093|ref|NP_060132.3| transient receptor potential cation
channel, subfamily M, member 6; hypomagnesemia, secondary
hypocalcemia [Homo sapiens]
gi|18860924|gb|AAK31202.2| channel-kinase 2 [Homo sapiens]
gi|20386048|gb|AAM21562.1| LTRPC6 channel kinase 2 [Homo sapiens]
gi|37790762|gb|AAR03487.1| transient receptor potential cation
channel subfamily M member 6 variant a [Homo sapiens]
Length = 2022
Score = 677 bits (1748), Expect = 0.0
Identities = 402/1246 (32%), Positives = 679/1246 (54%), Gaps = 52/1246 (4%)
Frame = +1
Query: 133 WIENTFEKRECIRFAALPKDPERCG-------------CGRPLSAHTPASTFFSTLPVHL 273
WI+ F+KREC K+P RC CGR + H A +S
Sbjct: 16 WIKGVFDKRECSTIIPSSKNPHRCTPVCQVCQNLIRCYCGRLIGDH--AGIDYSWTISAA 73
Query: 274 LEKEQQTWTIANNTQTSTTDAFGTIVFQGGAHAHKAQYVRLSYDSEPLDVMYLMEKVWGL 453
KE + W++ +T S TD FGTI FQ G H H A+Y+R SYD++ +++LM K W +
Sbjct: 74 KGKESEQWSVEKHTTKSPTDTFGTINFQDGEHTHHAKYIRTSYDTKLDHLLHLMLKEWKM 133
Query: 454 EAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTTGAWIITSGLDSGVVRHVAKALDE 633
E P+LVI+VHGG+ NF + + +F +G++KAA+TTGAWIIT G+++GV +HV AL
Sbjct: 134 ELPKLVISVHGGIQNFTMPSKFKEIFSQGLVKAAETTGAWIITEGINTGVSKHVGDALKS 193
Query: 634 AGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYYDVHSLSVNANVGILNDRHSYFLL 813
S+ +I T+GI PWGVI+ + LI ++ Y ++ + LN HS+F+L
Sbjct: 194 H--SSHSLRKIWTVGIPPWGVIENQRDLIGKDVVCLYQTLDNPLS-KLTTLNSMHSHFIL 250
Query: 814 ADNGTVGRFGADLHLRQNLENHIAT--FGCNGRK-VPVVCTLLEGGISSINAIHDYVTMK 984
+D+GTVG++G ++ LR+NLE +++ C R+ VPVV ++EGG + I ++ + T+K
Sbjct: 251 SDDGTVGKYGNEMKLRRNLEKYLSLQKIHCRSRQGVPVVGLVVEGGPNVILSVWE--TVK 308
Query: 985 PDIPAIVCDGSGRAADIISFAARYINSDGTFAAEVGEKLRNLIKMVFPET--DQEEMFRK 1158
P +VC+G+GRAAD+++F +++ +G +V E++ +I+ F + + +F+
Sbjct: 309 DKDPVVVCEGTGRAADLLAFTHKHLADEGMLRPQVKEEIICMIQNTFNFSLKQSKHLFQI 368
Query: 1159 ITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWNRVDLAKSCL 1338
+ EC++ D + IF EE++D+D IL+ +L+ NL EQL L ++W+RVD+AK +
Sbjct: 369 LMECMVHRDCITIFDADSEEQQDLDLAILTALLKGTNLSASEQLNLAMAWDRVDIAKKHI 428
Query: 1339 FSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLYNMDDINSAH 1518
+ W D LE+AM+DAL DRVDFV+ L+E GV++ FL+I RLE LYN +
Sbjct: 429 LIYEQHWKPDALEQAMSDALVMDRVDFVKLLIEYGVNLHRFLTIPRLEELYNTKQGPTNT 488
Query: 1519 SVRNWMENFDSMDPHTYL-----TIPMIGQVVEKLMGNAFQLYYTSRSFKGKYD----RY 1671
+ + +++ + HT L T+ IG VVE L+G A++ YT + F+ Y+ +Y
Sbjct: 489 LLHHLVQD---VKQHTLLSGYRITLIDIGLVVEYLIGRAYRSNYTRKHFRALYNNLYRKY 545
Query: 1672 KRINQSS---------------------YFHRKRKIVQKELFKKKSDDQINDNEEEDFSF 1788
K SS Y +++ IV + KK + ++D+ E F
Sbjct: 546 KHQRHSSGNRNESAESTLHSQFIRTAQPYKFKEKSIVLHKSRKKSKEQNVSDDPEST-GF 604
Query: 1789 AYPFNDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEEAKR 1968
YP+NDLL+WAVL R MA W HGE+A K ++A LY+A A A++ ++ + ++
Sbjct: 605 LYPYNDLLVWAVLMKRQKMAMFFWQHGEEATVKAVIACILYRAMAHEAKESHMVDDASEE 664
Query: 1969 LFDNAVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPC 2148
L + + + + A++LL++ ++ + + LL EL +W N+ CL LAV + F++H C
Sbjct: 665 LKNYSKQFGQLALDLLEKAFKQNERMAMTLLTYELRNWSNSTCLKLAVSGGLRPFVSHTC 724
Query: 2149 CQILLAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQLPYP 2328
Q+LL ++W G LK+R S ++++ ++I PP IL + +K K + S++ Y
Sbjct: 725 TQMLLTDMWMGRLKMRKNSWLKIIISIILPPTILTLEFKSKAEMSHVPQSQDFQFMWYYS 784
Query: 2329 RESITSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKNXXXXXXXXXXXXXXFKR 2508
++ +S SK KE LE+G K + ++
Sbjct: 785 DQNASS--------SKESASVKEYDLERGHDEK----LDENQHFGLESG----------- 821
Query: 2509 EPQLNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIYTVT 2688
L + FYS+PI KFW + +A+L FL T +L+E +PS EW+ IY T
Sbjct: 822 HQHLPWTRKVYEFYSAPIVKFWFYTMAYLAFLMLFTYTVLVEMQPQPSVQEWLVSIYIFT 881
Query: 2689 LSVEHIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSWGRVL 2868
++E +R++ SE + +KVKV+ ++++N+ + A+ F G+ R H+ GR++
Sbjct: 882 NAIEVVREICISEPGKFTQKVKVWISEYWNLTETVAIGLFSAGFVLRWGDPPFHTAGRLI 941
Query: 2869 LSFSNVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEP 3048
+ ++ ++ ++ +V+ GPY+ M AKM +M YI +++ + L++FGV R+A+ P
Sbjct: 942 YCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMTANMFYIVIIMAIVLLSFGVARKAILSP 1001
Query: 3049 NVKDWHWLLVRNIFYKPYFMLYGEVYAGEIDTCGDEGIRCFPGYFIPPLLMXXXXXXXXX 3228
+ W L R+I ++PY+M+YGEVYAGEID C + C PG F+ P L
Sbjct: 1002 K-EPPSWSLARDIVFEPYWMIYGEVYAGEIDVCSSQP-SCPPGSFLTPFLQAVYLFVQYI 1059
Query: 3229 XXXXXXXXXXXXXYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDYLY 3408
Y D S +W + RY+ +M YH+ P+LPPP + +HV + L
Sbjct: 1060 IMVNLLIAFFNNVYLDMESISNNLWKYNRYRYIMTYHEKPWLPPPLILLSHVGLLLRRLC 1119
Query: 3409 NLRRPDTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTL--TRIRKLKLNTKEPLSVTD- 3579
R P + + +KL ++++++K++ DFEE C++ ++ + + +E + VT
Sbjct: 1120 CHRAPHDQE-EGDVGLKLYLSKEDLKKLHDFEEQCVEKYFHEKMEDVNCSCEERIRVTSE 1178
Query: 3580 -LTELTCQRVHDLMQENFLLKSRVYDIETKIDHISNSSDEVVQILK 3714
+TE+ Q + ++ ++ +K + +++++ H+ + S V LK
Sbjct: 1179 RVTEMYFQ-LKEMNEKVSFIKDSLLSLDSQVGHLQDLSALTVDTLK 1223
>gi|37790766|gb|AAR03489.1| transient receptor potential cation
channel subfamily M member 6 variant c [Homo sapiens]
Length = 2017
Score = 677 bits (1748), Expect = 0.0
Identities = 402/1246 (32%), Positives = 679/1246 (54%), Gaps = 52/1246 (4%)
Frame = +1
Query: 133 WIENTFEKRECIRFAALPKDPERCG-------------CGRPLSAHTPASTFFSTLPVHL 273
WI+ F+KREC K+P RC CGR + H A +S
Sbjct: 11 WIKGVFDKRECSTIIPSSKNPHRCTPVCQVCQNLIRCYCGRLIGDH--AGIDYSWTISAA 68
Query: 274 LEKEQQTWTIANNTQTSTTDAFGTIVFQGGAHAHKAQYVRLSYDSEPLDVMYLMEKVWGL 453
KE + W++ +T S TD FGTI FQ G H H A+Y+R SYD++ +++LM K W +
Sbjct: 69 KGKESEQWSVEKHTTKSPTDTFGTINFQDGEHTHHAKYIRTSYDTKLDHLLHLMLKEWKM 128
Query: 454 EAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTTGAWIITSGLDSGVVRHVAKALDE 633
E P+LVI+VHGG+ NF + + +F +G++KAA+TTGAWIIT G+++GV +HV AL
Sbjct: 129 ELPKLVISVHGGIQNFTMPSKFKEIFSQGLVKAAETTGAWIITEGINTGVSKHVGDALKS 188
Query: 634 AGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYYDVHSLSVNANVGILNDRHSYFLL 813
S+ +I T+GI PWGVI+ + LI ++ Y ++ + LN HS+F+L
Sbjct: 189 H--SSHSLRKIWTVGIPPWGVIENQRDLIGKDVVCLYQTLDNPLS-KLTTLNSMHSHFIL 245
Query: 814 ADNGTVGRFGADLHLRQNLENHIAT--FGCNGRK-VPVVCTLLEGGISSINAIHDYVTMK 984
+D+GTVG++G ++ LR+NLE +++ C R+ VPVV ++EGG + I ++ + T+K
Sbjct: 246 SDDGTVGKYGNEMKLRRNLEKYLSLQKIHCRSRQGVPVVGLVVEGGPNVILSVWE--TVK 303
Query: 985 PDIPAIVCDGSGRAADIISFAARYINSDGTFAAEVGEKLRNLIKMVFPET--DQEEMFRK 1158
P +VC+G+GRAAD+++F +++ +G +V E++ +I+ F + + +F+
Sbjct: 304 DKDPVVVCEGTGRAADLLAFTHKHLADEGMLRPQVKEEIICMIQNTFNFSLKQSKHLFQI 363
Query: 1159 ITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWNRVDLAKSCL 1338
+ EC++ D + IF EE++D+D IL+ +L+ NL EQL L ++W+RVD+AK +
Sbjct: 364 LMECMVHRDCITIFDADSEEQQDLDLAILTALLKGTNLSASEQLNLAMAWDRVDIAKKHI 423
Query: 1339 FSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLYNMDDINSAH 1518
+ W D LE+AM+DAL DRVDFV+ L+E GV++ FL+I RLE LYN +
Sbjct: 424 LIYEQHWKPDALEQAMSDALVMDRVDFVKLLIEYGVNLHRFLTIPRLEELYNTKQGPTNT 483
Query: 1519 SVRNWMENFDSMDPHTYL-----TIPMIGQVVEKLMGNAFQLYYTSRSFKGKYD----RY 1671
+ + +++ + HT L T+ IG VVE L+G A++ YT + F+ Y+ +Y
Sbjct: 484 LLHHLVQD---VKQHTLLSGYRITLIDIGLVVEYLIGRAYRSNYTRKHFRALYNNLYRKY 540
Query: 1672 KRINQSS---------------------YFHRKRKIVQKELFKKKSDDQINDNEEEDFSF 1788
K SS Y +++ IV + KK + ++D+ E F
Sbjct: 541 KHQRHSSGNRNESAESTLHSQFIRTAQPYKFKEKSIVLHKSRKKSKEQNVSDDPEST-GF 599
Query: 1789 AYPFNDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEEAKR 1968
YP+NDLL+WAVL R MA W HGE+A K ++A LY+A A A++ ++ + ++
Sbjct: 600 LYPYNDLLVWAVLMKRQKMAMFFWQHGEEATVKAVIACILYRAMAHEAKESHMVDDASEE 659
Query: 1969 LFDNAVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPC 2148
L + + + + A++LL++ ++ + + LL EL +W N+ CL LAV + F++H C
Sbjct: 660 LKNYSKQFGQLALDLLEKAFKQNERMAMTLLTYELRNWSNSTCLKLAVSGGLRPFVSHTC 719
Query: 2149 CQILLAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQLPYP 2328
Q+LL ++W G LK+R S ++++ ++I PP IL + +K K + S++ Y
Sbjct: 720 TQMLLTDMWMGRLKMRKNSWLKIIISIILPPTILTLEFKSKAEMSHVPQSQDFQFMWYYS 779
Query: 2329 RESITSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKNXXXXXXXXXXXXXXFKR 2508
++ +S SK KE LE+G K + ++
Sbjct: 780 DQNASS--------SKESASVKEYDLERGHDEK----LDENQHFGLESG----------- 816
Query: 2509 EPQLNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIYTVT 2688
L + FYS+PI KFW + +A+L FL T +L+E +PS EW+ IY T
Sbjct: 817 HQHLPWTRKVYEFYSAPIVKFWFYTMAYLAFLMLFTYTVLVEMQPQPSVQEWLVSIYIFT 876
Query: 2689 LSVEHIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSWGRVL 2868
++E +R++ SE + +KVKV+ ++++N+ + A+ F G+ R H+ GR++
Sbjct: 877 NAIEVVREICISEPGKFTQKVKVWISEYWNLTETVAIGLFSAGFVLRWGDPPFHTAGRLI 936
Query: 2869 LSFSNVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEP 3048
+ ++ ++ ++ +V+ GPY+ M AKM +M YI +++ + L++FGV R+A+ P
Sbjct: 937 YCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMTANMFYIVIIMAIVLLSFGVARKAILSP 996
Query: 3049 NVKDWHWLLVRNIFYKPYFMLYGEVYAGEIDTCGDEGIRCFPGYFIPPLLMXXXXXXXXX 3228
+ W L R+I ++PY+M+YGEVYAGEID C + C PG F+ P L
Sbjct: 997 K-EPPSWSLARDIVFEPYWMIYGEVYAGEIDVCSSQP-SCPPGSFLTPFLQAVYLFVQYI 1054
Query: 3229 XXXXXXXXXXXXXYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDYLY 3408
Y D S +W + RY+ +M YH+ P+LPPP + +HV + L
Sbjct: 1055 IMVNLLIAFFNNVYLDMESISNNLWKYNRYRYIMTYHEKPWLPPPLILLSHVGLLLRRLC 1114
Query: 3409 NLRRPDTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTL--TRIRKLKLNTKEPLSVTD- 3579
R P + + +KL ++++++K++ DFEE C++ ++ + + +E + VT
Sbjct: 1115 CHRAPHDQE-EGDVGLKLYLSKEDLKKLHDFEEQCVEKYFHEKMEDVNCSCEERIRVTSE 1173
Query: 3580 -LTELTCQRVHDLMQENFLLKSRVYDIETKIDHISNSSDEVVQILK 3714
+TE+ Q + ++ ++ +K + +++++ H+ + S V LK
Sbjct: 1174 RVTEMYFQ-LKEMNEKVSFIKDSLLSLDSQVGHLQDLSALTVDTLK 1218
>gi|37790768|gb|AAR03490.1| truncated transient receptor potential
cation channel subfamily M member 6 variant a [Homo
sapiens]
Length = 1943
Score = 677 bits (1748), Expect = 0.0
Identities = 402/1246 (32%), Positives = 679/1246 (54%), Gaps = 52/1246 (4%)
Frame = +1
Query: 133 WIENTFEKRECIRFAALPKDPERCG-------------CGRPLSAHTPASTFFSTLPVHL 273
WI+ F+KREC K+P RC CGR + H A +S
Sbjct: 16 WIKGVFDKRECSTIIPSSKNPHRCTPVCQVCQNLIRCYCGRLIGDH--AGIDYSWTISAA 73
Query: 274 LEKEQQTWTIANNTQTSTTDAFGTIVFQGGAHAHKAQYVRLSYDSEPLDVMYLMEKVWGL 453
KE + W++ +T S TD FGTI FQ G H H A+Y+R SYD++ +++LM K W +
Sbjct: 74 KGKESEQWSVEKHTTKSPTDTFGTINFQDGEHTHHAKYIRTSYDTKLDHLLHLMLKEWKM 133
Query: 454 EAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTTGAWIITSGLDSGVVRHVAKALDE 633
E P+LVI+VHGG+ NF + + +F +G++KAA+TTGAWIIT G+++GV +HV AL
Sbjct: 134 ELPKLVISVHGGIQNFTMPSKFKEIFSQGLVKAAETTGAWIITEGINTGVSKHVGDALKS 193
Query: 634 AGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYYDVHSLSVNANVGILNDRHSYFLL 813
S+ +I T+GI PWGVI+ + LI ++ Y ++ + LN HS+F+L
Sbjct: 194 H--SSHSLRKIWTVGIPPWGVIENQRDLIGKDVVCLYQTLDNPLS-KLTTLNSMHSHFIL 250
Query: 814 ADNGTVGRFGADLHLRQNLENHIAT--FGCNGRK-VPVVCTLLEGGISSINAIHDYVTMK 984
+D+GTVG++G ++ LR+NLE +++ C R+ VPVV ++EGG + I ++ + T+K
Sbjct: 251 SDDGTVGKYGNEMKLRRNLEKYLSLQKIHCRSRQGVPVVGLVVEGGPNVILSVWE--TVK 308
Query: 985 PDIPAIVCDGSGRAADIISFAARYINSDGTFAAEVGEKLRNLIKMVFPET--DQEEMFRK 1158
P +VC+G+GRAAD+++F +++ +G +V E++ +I+ F + + +F+
Sbjct: 309 DKDPVVVCEGTGRAADLLAFTHKHLADEGMLRPQVKEEIICMIQNTFNFSLKQSKHLFQI 368
Query: 1159 ITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWNRVDLAKSCL 1338
+ EC++ D + IF EE++D+D IL+ +L+ NL EQL L ++W+RVD+AK +
Sbjct: 369 LMECMVHRDCITIFDADSEEQQDLDLAILTALLKGTNLSASEQLNLAMAWDRVDIAKKHI 428
Query: 1339 FSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLYNMDDINSAH 1518
+ W D LE+AM+DAL DRVDFV+ L+E GV++ FL+I RLE LYN +
Sbjct: 429 LIYEQHWKPDALEQAMSDALVMDRVDFVKLLIEYGVNLHRFLTIPRLEELYNTKQGPTNT 488
Query: 1519 SVRNWMENFDSMDPHTYL-----TIPMIGQVVEKLMGNAFQLYYTSRSFKGKYD----RY 1671
+ + +++ + HT L T+ IG VVE L+G A++ YT + F+ Y+ +Y
Sbjct: 489 LLHHLVQD---VKQHTLLSGYRITLIDIGLVVEYLIGRAYRSNYTRKHFRALYNNLYRKY 545
Query: 1672 KRINQSS---------------------YFHRKRKIVQKELFKKKSDDQINDNEEEDFSF 1788
K SS Y +++ IV + KK + ++D+ E F
Sbjct: 546 KHQRHSSGNRNESAESTLHSQFIRTAQPYKFKEKSIVLHKSRKKSKEQNVSDDPEST-GF 604
Query: 1789 AYPFNDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEEAKR 1968
YP+NDLL+WAVL R MA W HGE+A K ++A LY+A A A++ ++ + ++
Sbjct: 605 LYPYNDLLVWAVLMKRQKMAMFFWQHGEEATVKAVIACILYRAMAHEAKESHMVDDASEE 664
Query: 1969 LFDNAVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPC 2148
L + + + + A++LL++ ++ + + LL EL +W N+ CL LAV + F++H C
Sbjct: 665 LKNYSKQFGQLALDLLEKAFKQNERMAMTLLTYELRNWSNSTCLKLAVSGGLRPFVSHTC 724
Query: 2149 CQILLAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQLPYP 2328
Q+LL ++W G LK+R S ++++ ++I PP IL + +K K + S++ Y
Sbjct: 725 TQMLLTDMWMGRLKMRKNSWLKIIISIILPPTILTLEFKSKAEMSHVPQSQDFQFMWYYS 784
Query: 2329 RESITSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKNXXXXXXXXXXXXXXFKR 2508
++ +S SK KE LE+G K + ++
Sbjct: 785 DQNASS--------SKESASVKEYDLERGHDEK----LDENQHFGLESG----------- 821
Query: 2509 EPQLNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIYTVT 2688
L + FYS+PI KFW + +A+L FL T +L+E +PS EW+ IY T
Sbjct: 822 HQHLPWTRKVYEFYSAPIVKFWFYTMAYLAFLMLFTYTVLVEMQPQPSVQEWLVSIYIFT 881
Query: 2689 LSVEHIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSWGRVL 2868
++E +R++ SE + +KVKV+ ++++N+ + A+ F G+ R H+ GR++
Sbjct: 882 NAIEVVREICISEPGKFTQKVKVWISEYWNLTETVAIGLFSAGFVLRWGDPPFHTAGRLI 941
Query: 2869 LSFSNVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEP 3048
+ ++ ++ ++ +V+ GPY+ M AKM +M YI +++ + L++FGV R+A+ P
Sbjct: 942 YCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMTANMFYIVIIMAIVLLSFGVARKAILSP 1001
Query: 3049 NVKDWHWLLVRNIFYKPYFMLYGEVYAGEIDTCGDEGIRCFPGYFIPPLLMXXXXXXXXX 3228
+ W L R+I ++PY+M+YGEVYAGEID C + C PG F+ P L
Sbjct: 1002 K-EPPSWSLARDIVFEPYWMIYGEVYAGEIDVCSSQP-SCPPGSFLTPFLQAVYLFVQYI 1059
Query: 3229 XXXXXXXXXXXXXYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDYLY 3408
Y D S +W + RY+ +M YH+ P+LPPP + +HV + L
Sbjct: 1060 IMVNLLIAFFNNVYLDMESISNNLWKYNRYRYIMTYHEKPWLPPPLILLSHVGLLLRRLC 1119
Query: 3409 NLRRPDTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTL--TRIRKLKLNTKEPLSVTD- 3579
R P + + +KL ++++++K++ DFEE C++ ++ + + +E + VT
Sbjct: 1120 CHRAPHDQE-EGDVGLKLYLSKEDLKKLHDFEEQCVEKYFHEKMEDVNCSCEERIRVTSE 1178
Query: 3580 -LTELTCQRVHDLMQENFLLKSRVYDIETKIDHISNSSDEVVQILK 3714
+TE+ Q + ++ ++ +K + +++++ H+ + S V LK
Sbjct: 1179 RVTEMYFQ-LKEMNEKVSFIKDSLLSLDSQVGHLQDLSALTVDTLK 1223
>gi|45935366|ref|NP_996830.1| transient receptor potential cation
channel, subfamily M, member 3 isoform g; melastatin 2;
long transient receptor potential channel 3 [Homo
sapiens]
Length = 1569
Score = 677 bits (1747), Expect = 0.0
Identities = 394/1148 (34%), Positives = 637/1148 (55%), Gaps = 48/1148 (4%)
Frame = +1
Query: 385 YVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTT 564
YVR+S+D++P +++LM K W LE P+L+I+VHGG+ NFEL+ +L ++F KG++KAA TT
Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Query: 565 GAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYY 744
GAWI T G+++GV+RHV AL + +++ R +I TIGIAPWG+++ +E LI ++ Y
Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDH--ASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPY 119
Query: 745 DVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCN-------- 900
S + + + +LN HS+F+LADNGT G++GA++ LR+ LE HI+ N
Sbjct: 120 QTMS-NPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRCLPFFS 178
Query: 901 --------------------GRKVPVVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSG 1020
G+ VPVV ++EGG + I+ + +Y+ P +P +VCDGSG
Sbjct: 179 LDSRLFYSFWGSCQLDSVGIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSG 238
Query: 1021 RAADIISFAARYINSDGTFAAEVGEKLRNLIKMVF--PETDQEEMFRKITECVIRDDLLR 1194
RA+DI++F +Y G + ++L I+ F T + +F + EC+ + +L+
Sbjct: 239 RASDILAFGHKYSEEGGLINESLRDQLLVTIQKTFTYTRTQAQHLFIILMECMKKKELIT 298
Query: 1195 IFRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVL 1374
+FR G E +D+D IL+ +L+ N +QL+L L+WNRVD+A+S +F G++W L
Sbjct: 299 VFRMGSEGHQDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSL 358
Query: 1375 EKAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLYNMDDINS---AHSVRNWMENF 1545
E+AM DAL DRVDFV+ L+ENGVSM FL+I+RLE LYN S H VR+ +
Sbjct: 359 EQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKG- 417
Query: 1546 DSMDPHTYLTIPMIGQVVEKLMGNAFQLYYTSRSFKGKYDRYKRINQSSYFHRKRKIVQK 1725
++ P +++ IG V+E LMG A++ YT + F+ Y + R+ + K
Sbjct: 418 -NLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRDDIPLRRGRKTTK 476
Query: 1726 ELFKKKSDDQINDNEEEDFSFAYPFNDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIR 1905
K++ + I+ ++ E F +PF++L++WAVL R MA W HGE+AMAK L+A +
Sbjct: 477 ---KREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACK 533
Query: 1906 LYKATAKIAEDEYLDVEEAKRLFDNAVKCREDAIELLDQCYRADHDRTLRLLRMELPHWG 2085
L KA A A + + + ++ L N+ + A+ELLDQ Y+ D ++LL EL +W
Sbjct: 534 LCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWS 593
Query: 2086 NNNCLSLAVLANTKTFLAHPCCQILLAELWHGSLKVRSGSNVRVLTALICPPAILFMAYK 2265
N CL LAV A + F+AH C Q+LL ++W G L++R S ++V+ ++ PP+IL + +K
Sbjct: 594 NATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFK 653
Query: 2266 PKHSKTARLLSEETPEQLPYPRESITSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIIS 2445
K + +PY S + K EE ++ EK ++T +
Sbjct: 654 NK-------------DDMPY-----MSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAML 695
Query: 2446 SRKNXXXXXXXXXXXXXXFKREPQLNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCIL 2625
R N R L + + FY++PI KFW + +A++ +L I+
Sbjct: 696 GRNNGESSRKKDEEEVQSKHRLIPLGR--KIYEFYNAPIVKFWFYTLAYIGYLMLFNYIV 753
Query: 2626 LLETSLKPSKYEWITFIYTVTLSVEHIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLF 2805
L++ PS EWI Y TL +E +R+++ SE ++ +KVKV+ +++N+ A+L
Sbjct: 754 LVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILL 813
Query: 2806 FLVGYGFRLVPMYRHSWGRVLLSFSNVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYI 2985
F VG RL S GRV+ + + +Y+++ + V+ LGPY+ M KM+ M Y
Sbjct: 814 FSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYF 873
Query: 2986 CVLLLVPLMAFGVNRQALTEPNVKDWHWLLVRNIFYKPYFMLYGEVYAGEID-TCGDEGI 3162
+++LV LM+FGV RQA+ PN ++ W L +NIFY PY+M+YGEV+A +ID CG
Sbjct: 874 VIIMLVVLMSFGVARQAILFPN-EEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNET 932
Query: 3163 R----------CFPGYFIPPLLMXXXXXXXXXXXXXXXXXXXXXXYNDSIEKSKEIWLFQ 3312
R C G +I P +M + + S ++W FQ
Sbjct: 933 REDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQ 992
Query: 3313 RYQQLMEYHDSPFLPPPFSIFAHVYHFIDYL-YNLRRPDTKRFRSEHSIKLSVTEDEMKR 3489
RYQ +M +H+ P LPPP IF+H+ +L R+ ++ ++ +KL +T+DE+K+
Sbjct: 993 RYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKK 1052
Query: 3490 IQDFEEDCIDTLTRIRKLKLNTK--EPLSVT-DLTELTCQRVHDLMQENFLLKSRVYDIE 3660
+ DFEE CI+ R + + N+ E + VT + E R+ ++ + +K+ + ++
Sbjct: 1053 VHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVD 1112
Query: 3661 TKIDHISN 3684
++ + +
Sbjct: 1113 IRLAQLED 1120
>gi|27597207|dbj|BAC55103.1| hypothetical protein [Homo sapiens]
Length = 1569
Score = 677 bits (1747), Expect = 0.0
Identities = 394/1148 (34%), Positives = 637/1148 (55%), Gaps = 48/1148 (4%)
Frame = +1
Query: 385 YVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTT 564
YVR+S+D++P +++LM K W LE P+L+I+VHGG+ NFEL+ +L ++F KG++KAA TT
Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Query: 565 GAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYY 744
GAWI T G+++GV+RHV AL + +++ R +I TIGIAPWG+++ +E LI ++ Y
Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDH--ASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPY 119
Query: 745 DVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCN-------- 900
S + + + +LN HS+F+LADNGT G++GA++ LR+ LE HI+ N
Sbjct: 120 QTMS-NPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRCLPFFS 178
Query: 901 --------------------GRKVPVVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSG 1020
G+ VPVV ++EGG + I+ + +Y+ P +P +VCDGSG
Sbjct: 179 LDSHLFYSFWGSCQLDSVGIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSG 238
Query: 1021 RAADIISFAARYINSDGTFAAEVGEKLRNLIKMVF--PETDQEEMFRKITECVIRDDLLR 1194
RA+DI++F +Y G + ++L I+ F T + +F + EC+ + +L+
Sbjct: 239 RASDILAFGHKYSEEGGLINESLRDQLLVTIQKTFTYTRTQAQHLFIILMECMKKKELIT 298
Query: 1195 IFRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVL 1374
+FR G E +D+D IL+ +L+ N +QL+L L+WNRVD+A+S +F G++W L
Sbjct: 299 VFRMGSEGHQDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSL 358
Query: 1375 EKAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLYNMDDINS---AHSVRNWMENF 1545
E+AM DAL DRVDFV+ L+ENGVSM FL+I+RLE LYN S H VR+ +
Sbjct: 359 EQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKG- 417
Query: 1546 DSMDPHTYLTIPMIGQVVEKLMGNAFQLYYTSRSFKGKYDRYKRINQSSYFHRKRKIVQK 1725
++ P +++ IG V+E LMG A++ YT + F+ Y + R+ + K
Sbjct: 418 -NLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRDDIPLRRGRKTTK 476
Query: 1726 ELFKKKSDDQINDNEEEDFSFAYPFNDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIR 1905
K++ + I+ ++ E F +PF++L++WAVL R MA W HGE+AMAK L+A +
Sbjct: 477 ---KREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACK 533
Query: 1906 LYKATAKIAEDEYLDVEEAKRLFDNAVKCREDAIELLDQCYRADHDRTLRLLRMELPHWG 2085
L KA A A + + + ++ L N+ + A+ELLDQ Y+ D ++LL EL +W
Sbjct: 534 LCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWS 593
Query: 2086 NNNCLSLAVLANTKTFLAHPCCQILLAELWHGSLKVRSGSNVRVLTALICPPAILFMAYK 2265
N CL LAV A + F+AH C Q+LL ++W G L++R S ++V+ ++ PP+IL + +K
Sbjct: 594 NATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFK 653
Query: 2266 PKHSKTARLLSEETPEQLPYPRESITSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIIS 2445
K + +PY S + K EE ++ EK ++T +
Sbjct: 654 NK-------------DDMPY-----MSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAML 695
Query: 2446 SRKNXXXXXXXXXXXXXXFKREPQLNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCIL 2625
R N R L + + FY++PI KFW + +A++ +L I+
Sbjct: 696 GRNNGESSRKKDEEEVQSKHRLIPLGR--KIYEFYNAPIVKFWFYTLAYIGYLMLFNYIV 753
Query: 2626 LLETSLKPSKYEWITFIYTVTLSVEHIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLF 2805
L++ PS EWI Y TL +E +R+++ SE ++ +KVKV+ +++N+ A+L
Sbjct: 754 LVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILL 813
Query: 2806 FLVGYGFRLVPMYRHSWGRVLLSFSNVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYI 2985
F VG RL S GRV+ + + +Y+++ + V+ LGPY+ M KM+ M Y
Sbjct: 814 FSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYF 873
Query: 2986 CVLLLVPLMAFGVNRQALTEPNVKDWHWLLVRNIFYKPYFMLYGEVYAGEID-TCGDEGI 3162
+++LV LM+FGV RQA+ PN ++ W L +NIFY PY+M+YGEV+A +ID CG
Sbjct: 874 VIIMLVVLMSFGVARQAILFPN-EEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNET 932
Query: 3163 R----------CFPGYFIPPLLMXXXXXXXXXXXXXXXXXXXXXXYNDSIEKSKEIWLFQ 3312
R C G +I P +M + + S ++W FQ
Sbjct: 933 REDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQ 992
Query: 3313 RYQQLMEYHDSPFLPPPFSIFAHVYHFIDYL-YNLRRPDTKRFRSEHSIKLSVTEDEMKR 3489
RYQ +M +H+ P LPPP IF+H+ +L R+ ++ ++ +KL +T+DE+K+
Sbjct: 993 RYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKK 1052
Query: 3490 IQDFEEDCIDTLTRIRKLKLNTK--EPLSVT-DLTELTCQRVHDLMQENFLLKSRVYDIE 3660
+ DFEE CI+ R + + N+ E + VT + E R+ ++ + +K+ + ++
Sbjct: 1053 VHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVD 1112
Query: 3661 TKIDHISN 3684
++ + +
Sbjct: 1113 IRLAQLED 1120
>gi|23510305|ref|NP_700466.1| transient receptor potential cation
channel, subfamily M, member 6; transient receptor
potential cation channel 6/channel-kinase 2 [Mus
musculus]
gi|23306485|gb|AAN15217.1| transient receptor potential cation
channel 6/channel-kinase 2 [Mus musculus]
Length = 2028
Score = 676 bits (1745), Expect = 0.0
Identities = 405/1268 (31%), Positives = 678/1268 (52%), Gaps = 74/1268 (5%)
Frame = +1
Query: 133 WIENTFEKRECIRFAALPKDPERCG-------------CGRPLSAHTPASTFFSTLPVHL 273
WIE F KREC +F KDP RC CGR + H ++
Sbjct: 7 WIEGVFYKRECNKFIPSSKDPHRCTPGCQICHNLVRCYCGRLIEEHHGLDRAWNLSVTEG 66
Query: 274 LEKEQQTWTIANNTQTSTTDAFGTIVFQGGAHAHKAQYVRLSYDSEPLDVMYLMEKVWGL 453
EQ W++ +T S TD FGTI FQ G H H ++Y+R S+D++ +++LM K W +
Sbjct: 67 HGDEQ--WSVEKHTVKSPTDTFGTINFQDGEHIHHSKYIRTSWDTKSDHLLHLMLKEWNM 124
Query: 454 EAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTTGAWIITSGLDSGVVRHVAKALDE 633
E P+LVI+VHGG+ NF++ +L F +G++KAA+TTGAWIIT G++SGV +HV AL
Sbjct: 125 ELPKLVISVHGGLQNFKISSKLKETFSQGLVKAAETTGAWIITEGINSGVSKHVGDAL-- 182
Query: 634 AGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYYDVHSLSVNANVGILNDRHSYFLL 813
S++ +I T+GI PWGVI+ + L+ ++ Y + + + LN HS+F+L
Sbjct: 183 KAHSSKSLRKIWTVGIPPWGVIENQRELVGKDVVCMYQTLGNPL-SKLTTLNCMHSHFIL 241
Query: 814 ADNGTVGRFGADLHLRQNLENHIA---TFGCNGRKVPVVCTLLEGGISSINAIHDYVTMK 984
D+GTVG +G + LR+NLE H++ C+ + VPVV ++EGG + I + + T+K
Sbjct: 242 CDDGTVGMYGNEEKLRRNLEKHLSMQKIHTCSRQGVPVVGLVMEGGPNVI--LWVWETVK 299
Query: 985 PDIPAIVCDGSGRAADIISFAARYINSDGTFAAEVGEKLRNLIKMVFPET--DQEEMFRK 1158
P +VC+G+GRAAD+++F +++ G +V E+L LI+ +F + + +F+
Sbjct: 300 NKEPVVVCEGTGRAADLLAFTYKHLEDGGILRPQVKEELFCLIQNMFNFSLRQSKHLFQI 359
Query: 1159 ITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWNRVDLAKSCL 1338
+ EC++ D + IF EE +D+D IL+ +L+ +L EQL L ++W+R+D+AK +
Sbjct: 360 LMECMVHKDSITIFDADSEEHQDLDLAILTALLKGTSLSISEQLNLAMAWDRMDIAKKHI 419
Query: 1339 FSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLYNMDDINSAH 1518
+ G+ W LE+AM DAL DRVDFV+ L+ENGV++ FL+I RLE LYN +
Sbjct: 420 LTYGQHWKPGALEQAMLDALVMDRVDFVKLLIENGVNLHRFLTIPRLEELYNTKQGPTNK 479
Query: 1519 SVRNWMENFDSMDPHTYL-----TIPMIGQVVEKLMGNAFQLYYTSRSFKGKYDRYKRIN 1683
+R+ +++ + HT L T+ IG V+E L+G A++ YT +SF+ Y+ R +
Sbjct: 480 FLRHLVQD---VKQHTLLSSYRITLIDIGLVIEYLIGGAYRSSYTRKSFRILYNNLYRKH 536
Query: 1684 QS-------------------------------SYFHR-------KRKIVQKELFKKKSD 1749
+S S F R K K + KKKS
Sbjct: 537 KSVSSFAQGLSQHSLHQRHSLRNRKESSESTLHSQFFRTAQPYKSKEKPEDSQKSKKKSK 596
Query: 1750 DQINDNEE-EDFSFAYPFNDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAK 1926
++ + +EE E F YP+NDLL+WAVL R MA W HGE+A K ++A LY+A A+
Sbjct: 597 ERQSLSEEPEAAGFIYPYNDLLVWAVLMKRQNMAMFFWQHGEEATVKAVIASILYRAMAR 656
Query: 1927 IAEDEYLDVEEAKRLFDNAVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSL 2106
A++ + + ++ L + + + + A+++L++ ++ + ++LL EL +W N+ CL L
Sbjct: 657 EAKESNMVDDTSEELKNYSEQFGQLALDVLEKAFKQNEPMAMKLLTYELKNWSNSTCLKL 716
Query: 2107 AVLANTKTFLAHPCCQILLAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTA 2286
AV + F++H C Q+LL ++W G LK+R S ++++ +++ PP IL + +K K +
Sbjct: 717 AVSGGLRPFVSHSCTQMLLTDMWMGRLKMRKNSWLKIIISILLPPMILTLEFKSKAEMSH 776
Query: 2287 RLLSEETPEQLPYPRESITSTTSNR----YRYSKGPEEQKETLLEKGSYTKKVTIISSRK 2454
S++ Y + +++T + Y +GP+E+ + L
Sbjct: 777 VPQSQDFQFTWNYSDQGLSNTKESACVKDYDLERGPDEKPDEPLH--------------- 821
Query: 2455 NXXXXXXXXXXXXXXFKREPQ-LNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLL 2631
+ PQ L R FYS+P KFW + +A+L FL T +L+
Sbjct: 822 -------------LDLRNVPQSLPWTRRVYEFYSAPFVKFWFYTMAYLAFLMLFTYTVLV 868
Query: 2632 ETSLKPSKYEWITFIYTVTLSVEHIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFL 2811
E +PS +EW+ IY T ++E +R++ SE S+ +KVK++ ++++N+ + A+ F
Sbjct: 869 EMQPQPSVHEWLVIIYIFTNAIEKVREICISEPSKFKQKVKMWLSEYWNLMETVAIGLFA 928
Query: 2812 VGYGFRLVPMYRHSWGRVLLSFSNVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICV 2991
VG+G R + GR++ + ++ ++ ++ +V+ GPY+ M AKM +M YI +
Sbjct: 929 VGFGLRWGHPPLQTAGRLIYCIDIIFWFSRLMDFFAVNQHAGPYVTMIAKMAANMFYIVI 988
Query: 2992 LLLVPLMAFGVNRQALTEPNVKDWHWLLVRNIFYKPYFMLYGEVYAGEIDTCGDEGIRCF 3171
++ + L++FGV R+A+ P + W L R+I ++PY+M+YGEVYA +ID C +E C
Sbjct: 989 IMAIVLLSFGVARKAILSPK-EPPSWRLARDIVFEPYWMMYGEVYASDIDVCSNE-TSCP 1046
Query: 3172 PGYFIPPLLMXXXXXXXXXXXXXXXXXXXXXXYNDSIEKSKEIWLFQRYQQLMEYHDSPF 3351
PG F+ P L Y D S ++W + RY+ +M YH P+
Sbjct: 1047 PGSFLTPFLQAVYLFVQYIIMVNLLIACFNNIYLDIKSISNKLWKYNRYRYIMTYHQKPW 1106
Query: 3352 LPPPFSIFAHVYHFIDYLYNLRRPDTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTLTR 3531
LPPPF + H+ + L P + + +KL +T+D++K++ DFEE C++
Sbjct: 1107 LPPPFILLNHLCLLLRGLCCRPAPQDQE-EGDGGLKLYLTKDDLKKLHDFEEQCVEKYFH 1165
Query: 3532 IRKLKLNTKEPLSVTDLTELTCQRVHDLM-------QENFLLKSRVYDIETKIDHISNSS 3690
+ LN S + +T +RV ++ ++ +K + +++++ H+ + S
Sbjct: 1166 EKTEGLN----CSFEEQIRMTSERVSEMFFQLKEMNEKVSFIKDSLLSLDSQVGHLQDLS 1221
Query: 3691 DEVVQILK 3714
V LK
Sbjct: 1222 AITVDTLK 1229
>gi|45935364|ref|NP_996829.1| transient receptor potential cation
channel, subfamily M, member 3 isoform f; melastatin 2;
long transient receptor potential channel 3 [Homo
sapiens]
gi|27597211|dbj|BAC55105.1| hypothetical protein [Homo sapiens]
gi|28626257|gb|AAO49158.1| calcium-permeable store-operated channel
TRPM3f [Homo sapiens]
Length = 1579
Score = 674 bits (1740), Expect = 0.0
Identities = 396/1155 (34%), Positives = 638/1155 (54%), Gaps = 55/1155 (4%)
Frame = +1
Query: 385 YVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTT 564
YVR+S+D++P +++LM K W LE P+L+I+VHGG+ NFEL+ +L ++F KG++KAA TT
Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Query: 565 GAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYY 744
GAWI T G+++GV+RHV AL + +++ R +I TIGIAPWG+++ +E LI ++ Y
Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDH--ASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPY 119
Query: 745 DVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCN-------- 900
S + + + +LN HS+F+LADNGT G++GA++ LR+ LE HI+ N
Sbjct: 120 QTMS-NPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRCLPFFS 178
Query: 901 --------------------GRKVPVVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSG 1020
G+ VPVV ++EGG + I+ + +Y+ P +P +VCDGSG
Sbjct: 179 LDSRLFYSFWGSCQLDSVGIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSG 238
Query: 1021 RAADIISFAARYINSDGTFAAEVGEKLRNLIKMVF--PETDQEEMFRKITECVIRDDLLR 1194
RA+DI++F +Y G + ++L I+ F T + +F + EC+ + +L+
Sbjct: 239 RASDILAFGHKYSEEGGLINESLRDQLLVTIQKTFTYTRTQAQHLFIILMECMKKKELIT 298
Query: 1195 IFRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVL 1374
+FR G E +D+D IL+ +L+ N +QL+L L+WNRVD+A+S +F G++W L
Sbjct: 299 VFRMGSEGHQDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSL 358
Query: 1375 EKAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLYNMDDINS---AHSVRNWMENF 1545
E+AM DAL DRVDFV+ L+ENGVSM FL+I+RLE LYN S H VR+ +
Sbjct: 359 EQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKG- 417
Query: 1546 DSMDPHTYLTIPMIGQVVEKLMGNAFQLYYTSRSFKGKYDRY---KRINQSSYFHRKRKI 1716
++ P +++ IG V+E LMG A++ YT + F+ Y KR + I
Sbjct: 418 -NLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGMEDDI 476
Query: 1717 V----QKELFKKKSDDQINDNEEEDFSFAYPFNDLLIWAVLTSRHGMAECMWVHGEDAMA 1884
+K K++ + I+ ++ E F +PF++L++WAVL R MA W HGE+AMA
Sbjct: 477 PLRRGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMA 536
Query: 1885 KCLLAIRLYKATAKIAEDEYLDVEEAKRLFDNAVKCREDAIELLDQCYRADHDRTLRLLR 2064
K L+A +L KA A A + + + ++ L N+ + A+ELLDQ Y+ D ++LL
Sbjct: 537 KALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLT 596
Query: 2065 MELPHWGNNNCLSLAVLANTKTFLAHPCCQILLAELWHGSLKVRSGSNVRVLTALICPPA 2244
EL +W N CL LAV A + F+AH C Q+LL ++W G L++R S ++V+ ++ PP+
Sbjct: 597 YELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPS 656
Query: 2245 ILFMAYKPKHSKTARLLSEETPEQLPYPRESITSTTSNRYRYSKGPEEQKETLLEKGSYT 2424
IL + +K K + +PY S + K EE ++ EK
Sbjct: 657 ILSLEFKNK-------------DDMPY-----MSQAQEIHLQEKEAEEPEKPTKEKEEED 698
Query: 2425 KKVTIISSRKNXXXXXXXXXXXXXXFKREPQLNKFERFRAFYSSPITKFWSWCIAFLIFL 2604
++T + R N R L + + FY++PI KFW + +A++ +L
Sbjct: 699 MELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGR--KIYEFYNAPIVKFWFYTLAYIGYL 756
Query: 2605 TTQTCILLLETSLKPSKYEWITFIYTVTLSVEHIRKLMTSEGSRINEKVKVFYAKWYNIW 2784
I+L++ PS EWI Y TL +E +R+++ SE ++ +KVKV+ +++N+
Sbjct: 757 MLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVT 816
Query: 2785 TSAALLFFLVGYGFRLVPMYRHSWGRVLLSFSNVLFYMKIFEYLSVHPLLGPYIQMAAKM 2964
A+L F VG RL S GRV+ + + +Y+++ + V+ LGPY+ M KM
Sbjct: 817 DLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKM 876
Query: 2965 VWSMCYICVLLLVPLMAFGVNRQALTEPNVKDWHWLLVRNIFYKPYFMLYGEVYAGEID- 3141
+ M Y +++LV LM+FGV RQA+ PN ++ W L +NIFY PY+M+YGEV+A +ID
Sbjct: 877 MIDMMYFVIIMLVVLMSFGVARQAILFPN-EEPSWKLAKNIFYMPYWMIYGEVFADQIDP 935
Query: 3142 TCGDEGIR----------CFPGYFIPPLLMXXXXXXXXXXXXXXXXXXXXXXYNDSIEKS 3291
CG R C G +I P +M + + S
Sbjct: 936 PCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSIS 995
Query: 3292 KEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDYL-YNLRRPDTKRFRSEHSIKLSV 3468
++W FQRYQ +M +H+ P LPPP IF+H+ +L R+ ++ ++ +KL +
Sbjct: 996 NQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFI 1055
Query: 3469 TEDEMKRIQDFEEDCIDTLTRIRKLKLNTK--EPLSVT-DLTELTCQRVHDLMQENFLLK 3639
T+DE+K++ DFEE CI+ R + + N+ E + VT + E R+ ++ + +K
Sbjct: 1056 TDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMK 1115
Query: 3640 SRVYDIETKIDHISN 3684
+ + ++ ++ + +
Sbjct: 1116 ASLQTVDIRLAQLED 1130
>gi|27597213|dbj|BAC55106.1| hypothetical protein [Homo sapiens]
Length = 1526
Score = 660 bits (1702), Expect = 0.0
Identities = 383/1120 (34%), Positives = 625/1120 (55%), Gaps = 20/1120 (1%)
Frame = +1
Query: 385 YVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTT 564
YVR+S+D++P +++LM K W LE P+L+I+VHGG+ NFEL+ +L ++F KG++KAA TT
Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Query: 565 GAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYY 744
GAWI T G+++GV+RHV AL + +++ R +I TIGIAPWG+++ +E LI ++ Y
Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDH--ASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPY 119
Query: 745 DVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCN---GRKVP 915
S ++ + +LN HS+F+LADNGT G++GA++ LR+ LE HI+ N G+ VP
Sbjct: 120 QTMSNPMS-KLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVP 178
Query: 916 VVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFAAEVGE 1095
VV ++EGG + I+ + +Y+ P +P +VCDGSGRA+DI++F +Y G + +
Sbjct: 179 VVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRD 238
Query: 1096 KLRNLIKMVFP--ETDQEEMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQN 1269
+L I+ F T + +F + EC+ + +L+ +FR G E +D+D IL+ +L+ N
Sbjct: 239 QLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGAN 298
Query: 1270 LPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENGVS 1449
+QL+L L+WNRVD+A+S +F G++W LE+AM DAL DRVDFV+ L+ENG
Sbjct: 299 ASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGRH 358
Query: 1450 MKNFLSINRLENLYNMDDINSAHSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNAFQL 1629
+ LY H VR+ + ++ P +++ IG V+E LMG A++
Sbjct: 359 GPS-------NTLY--------HLVRDVKKG--NLPPDYRISLIDIGLVIEYLMGGAYRC 401
Query: 1630 YYTSRSFKGKYDRYKRINQSSYFHRKRKIVQKELFKKKSDDQINDNEEEDFSFAYPFNDL 1809
YT + F+ Y + R+ + K K++ + I+ ++ E F +PF++L
Sbjct: 402 NYTRKRFRTLYHNLFGPKRDDIPLRRGRKTTK---KREEEVDIDLDDPEINHFPFPFHEL 458
Query: 1810 LIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEEAKRLFDNAVK 1989
++WAVL R MA W HGE+AMAK L+A +L KA A A + + + ++ L N+
Sbjct: 459 MVWAVLMKRQKMALFFWQHGEEAMAKALVAYKLCKAMAHEASENDMVDDISQELNHNSRD 518
Query: 1990 CREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPCCQILLAE 2169
+ A+ELLDQ Y+ D ++LL EL +W N CL LAV A + F+AH C Q+LL +
Sbjct: 519 FGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTD 578
Query: 2170 LWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQLPYPRESITST 2349
+W G L++R S ++V+ ++ PP+IL + +K K + +PY S
Sbjct: 579 MWMGRLRMRKNSGLKVILGILLPPSILSLEFKNK-------------DDMPY-----MSQ 620
Query: 2350 TSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKNXXXXXXXXXXXXXXFKREPQLNKF 2529
+ K EE ++ EK ++T + R N R L +
Sbjct: 621 AQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGR- 679
Query: 2530 ERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIYTVTLSVEHIR 2709
+ FY++PI KFW + +A++ +L I+L++ PS EWI Y TL +E +R
Sbjct: 680 -KIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMR 738
Query: 2710 KLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSWGRVLLSFSNVL 2889
+++ SE ++ +KVKV+ +++N+ A+L F VG RL S GRV+ + +
Sbjct: 739 EILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIY 798
Query: 2890 FYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEPNVKDWHW 3069
+Y+++ + V+ LGPY+ M KM+ M Y +++LV LM+FGV RQA+ PN ++ W
Sbjct: 799 WYIRLLDIFGVNKYLGPYVMMIGKMMIEMMYFVIIMLVVLMSFGVARQAILFPN-EEPSW 857
Query: 3070 LLVRNIFYKPYFMLYGEVYAGEID-TCGDEGIR----------CFPGYFIPPLLMXXXXX 3216
L +NIFY PY+M+YGEV+A +ID CG R C G +I P +M
Sbjct: 858 KLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLL 917
Query: 3217 XXXXXXXXXXXXXXXXXYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFI 3396
+ + S ++W FQRYQ +M +H+ P LPPP IF+H+
Sbjct: 918 VANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIF 977
Query: 3397 DYL-YNLRRPDTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTLTRIRKLKLNTK--EPL 3567
+L R+ ++ ++ +KL +T+DE+K++ DFEE CI+ R + + N+ E +
Sbjct: 978 QHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERI 1037
Query: 3568 SVT-DLTELTCQRVHDLMQENFLLKSRVYDIETKIDHISN 3684
VT + E R+ ++ + +K+ + ++ ++ + +
Sbjct: 1038 RVTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLED 1077
>gi|50752897|ref|XP_425066.1| PREDICTED: similar to transient receptor
potential cation channel, subfamily M, member 1;
melastatin 1 [Gallus gallus]
Length = 1574
Score = 641 bits (1653), Expect = 0.0
Identities = 394/1271 (30%), Positives = 664/1271 (51%), Gaps = 70/1271 (5%)
Frame = +1
Query: 112 TEKLSPPWIENTFEKRECIRFAALPKDPERCGCGRPLSAHTPASTFFSTLP----VHLLE 279
++K WIE TF KRECI A KD RC CG+ ++ H P + +E
Sbjct: 17 SQKGQKAWIEKTFSKRECIYVIANNKDISRCCCGQLITQHIPPPPSTTANKNGEETKQVE 76
Query: 280 KEQQTWTIANNTQTSTTDAFGTIVFQGGAHAHKAQYVRLSYDSEPLDVMYLMEKVWGLEA 459
+ + W+++ +TQT TDA+G + FQGG H++KA Y+R+SYD++P +++LM K W LE
Sbjct: 77 AQPEKWSVSKHTQTYPTDAYGNLEFQGGGHSNKAMYIRVSYDTKPDSLLHLMVKDWQLEL 136
Query: 460 PRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTTGAWIITSGLDSGVVRHVAKALDEAG 639
P+L+I+VHGG+ NFE++ +L ++F KG++KAA TTGAWI T G+ +GV+RHV AL +
Sbjct: 137 PKLLISVHGGLQNFEMQPKLKQVFGKGLIKAAMTTGAWIFTGGVSTGVIRHVGDALKDH- 195
Query: 640 ISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYYDVHSLSVNANVGILNDRHSYFLLAD 819
S++ R +I IGIAPWG+++ KE LI ++ Y S + + + +LN H++F+LAD
Sbjct: 196 -SSKSRGRICAIGIAPWGIVENKEDLIGKDVTRVYQTMSNPL-SKLSVLNSSHTHFILAD 253
Query: 820 NGTVGRFGADLHLRQNLENHIATFGCN---GRKVPVVCTLLEGGISSINAIHDYVTMKPD 990
NGT+G++GA++ LR+ LE HI+ N G+ VPVV ++EGG + I+ + + + +P
Sbjct: 254 NGTLGKYGAEVKLRRQLEKHISLQKINTRLGQGVPVVGLIVEGGPNVISIVLECLREEPP 313
Query: 991 IPAIVCDGSGRAADIISFAARYINSDGTFAAEVGEKLRNLIKMVF--PETDQEEMFRKIT 1164
+P ++CDGSGRA+DI+SFA +Y G + + ++L I+ F ++F +
Sbjct: 314 LPVVICDGSGRASDILSFAHKYSEEGGIISESLRDQLLVTIQKTFNYSRNQAHQLFIILM 373
Query: 1165 ECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWNRVDLAKSCLFS 1344
EC+ + +L+ +FR G E ++D++ IL+ +L+ N +QL+L L+WNRVD+A+S +F
Sbjct: 374 ECMKKKELITVFRMGSEGQQDIEMSILTALLKGTNASAPDQLSLALAWNRVDIARSQIFV 433
Query: 1345 NGRKW-------------------SSDVLEKAM--------------------NDALYWD 1407
G W S V KA D +
Sbjct: 434 FGHHWPPLGSLTAGDGTAPEKEKKSPAVQTKAARGKGKGKKKGGKVKEEPEEETDPRKLE 493
Query: 1408 RVDFVECLLENGVSMKNFLSINRLE--NLYNMDDINSAHSVR----NWMENFDSMDPHTY 1569
+++V L + +M + L ++R++ L + +N H + + N ++ P +
Sbjct: 494 LLNWVNSLEQ---AMLDALVLDRVDFVKLLIENGVNMQHFLTIPRLEELYNTGNLPPDYH 550
Query: 1570 LTIPMIGQVVEKLMGNAFQLYYTSRSFKGKYDRY---KRINQSSYFHRKRKIVQKELFKK 1740
+++ IG V+E LMG A++ YT +SF+ Y+ KR ++ +K+K KK
Sbjct: 551 ISLIDIGLVLEYLMGGAYRCNYTRKSFRTLYNNLFGPKRDDEPPTKGKKKK------KKK 604
Query: 1741 KSDDQINDNEEEDFSFAYPFNDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKAT 1920
+ + I+ ++ E F YPF++L++WAVL R MA +W GE+ MAK L+A +LYK+
Sbjct: 605 EEEIDIDVDDPEVSRFQYPFHELMLWAVLMKRQKMALFLWQRGEETMAKALVACKLYKSM 664
Query: 1921 AKIAEDEYLDVEEAKRLFDNAVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCL 2100
A + + L + ++ L +N+ + A+ELLDQ Y+ D ++LL EL +W N+ CL
Sbjct: 665 AHESSESELVDDISQDLDNNSKDFGQLAVELLDQSYKHDEQIAMKLLTYELKNWSNSTCL 724
Query: 2101 SLAVLANTKTFLAHPCCQILLAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSK 2280
LAV A + F+AH C Q+LL ++W G L++R ++V+ ++ PP ILF+ ++ +
Sbjct: 725 KLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNPGLKVIMGILFPPTILFLEFR-SYDD 783
Query: 2281 TARLLSEETPEQLPYPRESITSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKNX 2460
+ S E E E++ + R KG EE
Sbjct: 784 YSYQTSRENEEGKEKEEENVDANVDTGSR--KGDEENGN--------------------- 820
Query: 2461 XXXXXXXXXXXXXFKREPQLNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETS 2640
K++ L + FY++PI KFW
Sbjct: 821 --------------KKQNSLPIGTKIYEFYNAPIVKFW---------------------- 844
Query: 2641 LKPSKYEWITFIYTVTLSVEHIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGY 2820
YT+ + SE ++++KVKV+ +++NI A+ F++G
Sbjct: 845 -----------FYTI----------LMSEPGKLSQKVKVWLQEYWNITDLVAISVFMIGA 883
Query: 2821 GFRLVPMYRHSWGRVLLSFSNVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLL 3000
RL +GRV+ + +Y+++ + V+ LGPY+ M KM+ M Y V++L
Sbjct: 884 ILRLQNQPYMGYGRVIYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIML 943
Query: 3001 VPLMAFGVNRQALTEPNVKDWHWLLVRNIFYKPYFMLYGEVYAGEID-TCGD-----EGI 3162
V LM+FGV RQA+ P+ ++ W L RNIFY PY+M+YGEV+A +ID CGD +G
Sbjct: 944 VVLMSFGVARQAILHPD-EEPSWRLARNIFYMPYWMIYGEVFADQIDPPCGDNLYDEDGK 1002
Query: 3163 R---CFPGYFIPPLLMXXXXXXXXXXXXXXXXXXXXXXYNDSIEKSKEIWLFQRYQQLME 3333
R C PG ++ P +M + + S ++W FQRYQ +M
Sbjct: 1003 RLPPCIPGAWLTPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMT 1062
Query: 3334 YHDSPFLPPPFSIFAHVYHFIDYL-YNLRRPDTKRFRSEHSIKLSVTEDEMKRIQDFEED 3510
+HD P LPPP IF+H+Y I + ++ + + + +KL + ++E+K++ +FEE
Sbjct: 1063 FHDRPVLPPPMIIFSHLYIIIKRVCCRCKKREGDQDERDRGLKLFLNDEELKKLYEFEEQ 1122
Query: 3511 CIDTLTRIR--KLKLNTKEPLSVT-DLTELTCQRVHDLMQENFLLKSRVYDIETKIDHIS 3681
C++ + + + + + E + VT + E R+ ++ + +K+ + ++ ++ +
Sbjct: 1123 CVEEYFQEKEDEQQSSNDERIRVTSERVENMSMRLEEVNEREHFMKASLQTVDLRLSQLE 1182
Query: 3682 NSSDEVVQILK 3714
S +V L+
Sbjct: 1183 ELSGRMVNALE 1193