Homology by BLASTX
BLASTX 2.2.4 [Aug-26-2002]
Query= F58H1_2
(3432 letters)
Database: /home/niguts/usr02/tshini/ykclst/db/nr.seq
1,967,186 sequences; 661,712,633 total letters
Score E
Sequences producing significant alignments: (bits) Value
gi|17561670|ref|NP_505995.1| alpha-mannosidase ii (5M408) [Caeno... 2251 0.0
gi|39592130|emb|CAE75350.1| Hypothetical protein CBG23330 [Caeno... 2021 0.0
gi|49117994|gb|AAH72937.1| Unknown (protein for MGC:80473) [Xeno... 728 0.0
gi|3122380|sp|Q16706|M2A1_HUMAN Alpha-mannosidase II (Mannosyl-o... 724 0.0
gi|4758698|ref|NP_002363.1| mannosidase, alpha, class 2A, member... 719 0.0
gi|6678790|ref|NP_032575.1| mannosidase 2, alpha 1 [Mus musculus... 713 0.0
gi|517481|emb|CAA54732.1| putative golgi alpha-mannosidase II [D... 705 0.0
gi|47219822|emb|CAG03449.1| unnamed protein product [Tetraodon n... 705 0.0
gi|24645354|ref|NP_524291.2| CG18802-PA [Drosophila melanogaster... 702 0.0
gi|4220556|emb|CAA10755.1| alpha-mannosidase II [Drosophila mela... 701 0.0
gi|18655827|pdb|1HXK|A Chain A, Golgi Alpha-Mannosidase Ii In Co... 697 0.0
gi|37928076|pdb|1QWN|A Chain A, Golgi Alpha-Mannosidase Ii Coval... 697 0.0
gi|40889325|pdb|1PS3|A Chain A, Golgi Alpha-Mannosidase Ii In Co... 697 0.0
gi|37928081|pdb|1QWU|A Chain A, Golgi Alpha-Mannosidase Ii D341n... 696 0.0
gi|31231176|ref|XP_318477.1| ENSANGP00000014255 [Anopheles gambi... 682 0.0
gi|25529601|pir||JC4037 alpha-mannosidase II, Golgi - fruit fly ... 667 0.0
gi|18158757|pdb|1HTY|A Chain A, Golgi Alpha-Mannosidase Ii 667 0.0
gi|3123244|sp|P49641|M2A2_HUMAN Alpha-mannosidase IIx (Mannosyl-... 659 0.0
gi|50753420|ref|XP_413979.1| PREDICTED: similar to Alpha-mannosi... 643 0.0
gi|34857364|ref|XP_218816.2| similar to Alpha-mannosidase IIx (M... 615 e-174
gi|49523304|gb|AAH75578.1| Unknown (protein for MGC:89555) [Xeno... 605 e-171
gi|15242174|ref|NP_196999.1| glycosyl hydrolase family 38 protei... 594 e-168
gi|34877940|ref|XP_343637.1| Mannosidase 2, alpha 1 [Rattus norv... 545 e-153
gi|4433616|gb|AAD20813.1| alpha-mannosidase IIx [Mus musculus] 537 e-151
gi|27777691|ref|NP_766491.1| mannosidase 2, alpha 2; mannosidase... 537 e-151
gi|5540100|ref|NP_006113.1| mannosidase, alpha, class 2A, member... 534 e-150
gi|48111098|ref|XP_396290.1| similar to ENSANGP00000010944 [Apis... 526 e-147
gi|7511787|pir||T29089 alpha-mannosidase (EC 3.2.1.-), class II ... 483 e-134
gi|126723|sp|P28494|M2A1_RAT Alpha-mannosidase II (Mannosyl-olig... 481 e-134
gi|7514006|pir||A33901 mannosyl-oligosaccharide 1,3-1,6-alpha-ma... 481 e-134
gi|807679|gb|AAA66457.1| alpha-mannosidase II 480 e-134
gi|35764404|dbj|BAC92711.1| alpha-mannosidase [Drosophila melano... 475 e-132
gi|24647249|ref|NP_650494.2| CG4606-PA [Drosophila melanogaster]... 475 e-132
gi|31201275|ref|XP_309585.1| ENSANGP00000010944 [Anopheles gambi... 474 e-132
gi|4519906|dbj|BAA75817.1| alpha-mannosidase [Drosophila melanog... 472 e-131
gi|47209153|emb|CAF89893.1| unnamed protein product [Tetraodon n... 462 e-128
gi|38260678|gb|AAR15492.1| glycosyl hydrolase [Arabidopsis arenosa] 449 e-124
gi|50058062|gb|AAB52345.2| Hypothetical protein F48C1.1a [Caenor... 423 e-116
gi|21428424|gb|AAM49872.1| LD09921p [Drosophila melanogaster] 403 e-110
gi|25144057|ref|NP_740847.1| mannosidase alpha (1F897) [Caenorha... 318 4e-85
gi|50753312|ref|XP_413953.1| PREDICTED: similar to Alpha-mannosi... 315 6e-84
gi|33086502|gb|AAP92563.1| Aa2-111 [Rattus norvegicus] 302 4e-80
gi|39589706|emb|CAE66941.1| Hypothetical protein CBG12333 [Caeno... 301 9e-80
gi|19921088|ref|NP_609408.1| CG6206-PA [Drosophila melanogaster]... 270 2e-70
gi|24583443|ref|NP_723591.1| CG6206-PB [Drosophila melanogaster]... 266 2e-69
gi|15231611|ref|NP_189306.1| glycosyl hydrolase family 38 protei... 265 4e-69
gi|1914843|gb|AAC09470.1| lysosomal alpha-mannosidase [Mus muscu... 265 6e-69
gi|17380364|sp|O09159|M2B1_MOUSE Lysosomal alpha-mannosidase pre... 265 6e-69
gi|1478074|gb|AAC53369.1| alpha-D-mannosidase 265 6e-69
gi|6754622|ref|NP_034894.1| mannosidase 2, alpha B1; lysosomal a... 265 6e-69
gi|12836285|dbj|BAB23588.1| unnamed protein product [Mus musculus] 264 1e-68
gi|40786505|ref|NP_955436.1| similar to mannosidase 2, alpha B1 ... 261 6e-68
gi|41017372|sp|Q8VHC8|M2B1_CAVPO Lysosomal alpha-mannosidase pre... 261 6e-68
gi|18140137|gb|AAL58983.1| lysosomal alpha-mannosidase [Cavia po... 261 6e-68
gi|18140139|gb|AAL58984.1| lysosomal alpha-mannosidase [Cavia po... 261 6e-68
gi|15239274|ref|NP_201416.1| glycosyl hydrolase family 38 protei... 257 1e-66
gi|30684695|ref|NP_851037.1| glycosyl hydrolase family 38 protei... 254 1e-65
gi|1658374|gb|AAC50812.1| lysosomal acid alpha-mannosidase [Homo... 254 1e-65
gi|22326796|ref|NP_196902.2| glycosyl hydrolase family 38 protei... 254 1e-65
gi|1419374|gb|AAB03816.1| alpha-mannosidase 253 2e-65
gi|462566|sp|P34098|MANA_DICDI Lysosomal alpha-mannosidase precu... 252 4e-65
gi|283451|pir||A42265 alpha-mannosidase (EC 3.2.1.24) - slime mo... 252 4e-65
gi|10177664|dbj|BAB11126.1| alpha-mannosidase [Arabidopsis thali... 252 5e-65
gi|6225643|sp|O46432|M2B1_FELCA Lysosomal alpha-mannosidase prec... 252 5e-65
gi|12653887|gb|AAH00736.1| Mannosidase, alpha, class 2B, member ... 251 8e-65
gi|10834968|ref|NP_000519.1| mannosidase, alpha, class 2B, membe... 251 8e-65
gi|3522867|gb|AAC34130.1| lysosomal alpha-mannosidase [Homo sapi... 250 1e-64
gi|31341666|ref|NP_776986.2| mannosidase, alpha B, lysosomal [ma... 247 1e-63
gi|47217297|emb|CAG12505.1| unnamed protein product [Tetraodon n... 247 2e-63
gi|24582926|ref|NP_609251.1| CG9465-PA [Drosophila melanogaster]... 246 2e-63
gi|38090217|ref|XP_356218.1| similar to Lysosomal alpha-mannosid... 246 2e-63
gi|24583440|ref|NP_609407.1| CG5322-PA [Drosophila melanogaster]... 245 5e-63
gi|21430578|gb|AAM50967.1| RE08556p [Drosophila melanogaster] 244 1e-62
gi|24582929|ref|NP_609253.1| CG9468-PA [Drosophila melanogaster]... 243 2e-62
gi|19920972|ref|NP_609252.1| CG9466-PA [Drosophila melanogaster]... 240 1e-61
gi|17568171|ref|NP_508811.1| lysosomal alpha-mannosidase (109.3 ... 236 2e-60
gi|24582924|ref|NP_609250.2| CG9463-PA [Drosophila melanogaster]... 236 2e-60
gi|40215626|gb|AAL48871.2| RE28991p [Drosophila melanogaster] 234 8e-60
gi|4322302|gb|AAD16005.1| lysosomal acid alpha-mannosidase precu... 221 7e-56
gi|6678792|ref|NP_032576.1| mannosidase alpha class 2B member 2;... 221 9e-56
gi|47523156|ref|NP_999014.1| 135kDa alpha-D-mannosidase [Sus scr... 221 1e-55
gi|17380350|sp|Q28949|M2B2_PIG Epididymis-specific alpha-mannosi... 221 1e-55
gi|26333725|dbj|BAC30580.1| unnamed protein product [Mus musculu... 219 3e-55
gi|12836435|dbj|BAB23655.1| unnamed protein product [Mus musculus] 219 4e-55
gi|31211435|ref|XP_314687.1| ENSANGP00000013227 [Anopheles gambi... 218 1e-54
gi|34878431|ref|XP_341234.1| similar to Epididymis-specific alph... 217 1e-54
gi|39597950|emb|CAE68642.1| Hypothetical protein CBG14532 [Caeno... 213 3e-53
gi|17369906|sp|Q9Y2E5|M2B2_HUMAN Epididymis-specific alpha-manno... 209 5e-52
gi|22042434|ref|XP_052620.6| mannosidase alpha class 2B member 2... 208 8e-52
gi|7504293|pir||T16459 hypothetical protein F55D10.1 - Caenorhab... 207 1e-51
gi|32822711|gb|AAH55006.1| Unknown (protein for MGC:57099) [Mus ... 206 3e-51
gi|30268358|emb|CAD89971.1| hypothetical protein [Homo sapiens] 204 9e-51
gi|47227432|emb|CAG04580.1| unnamed protein product [Tetraodon n... 204 2e-50
gi|50747250|ref|XP_420805.1| PREDICTED: similar to hypothetical ... 201 1e-49
gi|31211439|ref|XP_314689.1| ENSANGP00000013096 [Anopheles gambi... 197 1e-48
gi|2345045|gb|AAC48763.1| lysosomal alpha-mannosidase [Bos taurus] 187 2e-45
gi|37530954|ref|NP_919779.1| putative alpha-mannosidase [Oryza s... 181 1e-43
gi|627372|pir||JC2200 alpha-mannosidase (EC 3.2.1.24) precursor ... 173 2e-41
gi|34877942|ref|XP_217493.2| similar to mannosyl-oligosaccharide... 166 4e-39
gi|47200787|emb|CAF87950.1| unnamed protein product [Tetraodon n... 144 1e-32
gi|47193348|emb|CAF87266.1| unnamed protein product [Tetraodon n... 137 2e-30
gi|4589514|dbj|BAA76779.1| KIAA0935 protein [Homo sapiens] 131 1e-28
gi|29726874|pdb|1O7D|A Chain A, The Structure Of The Bovine Lyso... 124 1e-26
gi|33086610|gb|AAP92617.1| Ab2-450 [Rattus norvegicus] 124 2e-26
gi|1663627|gb|AAC50811.1| truncated lysosomal acid alpha-mannosi... 119 7e-25
gi|25144060|ref|NP_740848.1| alpha-mannosidase (1F897) [Caenorha... 112 5e-23
gi|15450679|gb|AAK96611.1| AT5g14950/F2G14_70 [Arabidopsis thali... 98 2e-18
gi|26344143|dbj|BAC35728.1| unnamed protein product [Mus musculus] 96 6e-18
gi|31211437|ref|XP_314688.1| ENSANGP00000023272 [Anopheles gambi... 90 3e-16
gi|29726877|pdb|1O7D|D Chain D, The Structure Of The Bovine Lyso... 86 5e-15
gi|7489713|pir||T02957 alpha-mannosidase (EC 3.2.1.24) 1 - maize... 83 5e-14
gi|16801189|ref|NP_471457.1| similar to alpha-mannosidase [Liste... 76 5e-12
gi|37530956|ref|NP_919780.1| putative alpha-mannosidase [Oryza s... 73 5e-11
gi|15644594|ref|NP_229647.1| alpha-mannosidase, putative [Thermo... 72 7e-11
gi|23335442|ref|ZP_00120678.1| COG0383: Alpha-mannosidase [Bifid... 70 3e-10
gi|23465890|ref|NP_696493.1| alpha-mannosidase [Bifidobacterium ... 67 2e-09
gi|47123126|gb|AAH70781.1| MGC83821 protein [Xenopus laevis] 66 5e-09
gi|15613354|ref|NP_241657.1| alpha-mannosidase [Bacillus halodur... 65 1e-08
gi|46191050|ref|ZP_00120680.2| COG0383: Alpha-mannosidase [Bifid... 62 9e-08
gi|23465888|ref|NP_696491.1| alpha-mannosidase [Bifidobacterium ... 62 9e-08
gi|46135168|ref|ZP_00162469.2| COG0383: Alpha-mannosidase [Anaba... 62 1e-07
gi|3860075|gb|AAC72969.1| lysosomal alpha mannosidase [Trypanoso... 61 2e-07
gi|49091224|ref|XP_407073.1| hypothetical protein AN2936.2 [Aspe... 60 3e-07
gi|50841553|ref|YP_054780.1| glycosyl hydrolase [Propionibacteri... 60 4e-07
gi|23129514|ref|ZP_00111341.1| COG0383: Alpha-mannosidase [Nosto... 60 5e-07
gi|12054808|emb|CAC20908.1| mannosyl-oligosaccharide 1,3-1,6-alp... 59 6e-07
gi|23465889|ref|NP_696492.1| alpha-mannosidase [Bifidobacterium ... 59 8e-07
gi|48895496|ref|ZP_00328480.1| COG0383: Alpha-mannosidase [Trich... 59 8e-07
gi|46191049|ref|ZP_00120679.2| COG0383: Alpha-mannosidase [Bifid... 59 8e-07
gi|7493924|pir||T30525 alpha-mannosidase (EC 3.2.1.24) - Emerice... 59 1e-06
gi|50551311|ref|XP_503129.1| hypothetical protein [Yarrowia lipo... 58 1e-06
gi|46908244|ref|YP_014633.1| alpha-D-mannosidase [Listeria monoc... 58 1e-06
gi|47093185|ref|ZP_00230959.1| alpha-D-mannosidase [Listeria mon... 58 1e-06
gi|38105226|gb|EAA51678.1| hypothetical protein MG03273.4 [Magna... 58 2e-06
gi|49067765|ref|XP_398172.1| hypothetical protein UM00557.1 [Ust... 57 3e-06
gi|17228343|ref|NP_484891.1| putative alpha-mannosidase [Nostoc ... 56 7e-06
gi|32414421|ref|XP_327690.1| hypothetical protein [Neurospora cr... 55 1e-05
gi|50286965|ref|XP_445912.1| unnamed protein product [Candida gl... 55 1e-05
gi|18309838|ref|NP_561772.1| alpha-mannosidase [Clostridium perf... 55 1e-05
gi|47225854|emb|CAF98334.1| unnamed protein product [Tetraodon n... 55 1e-05
gi|45547555|ref|ZP_00187601.1| COG0383: Alpha-mannosidase [Rubro... 54 2e-05
gi|19114891|ref|NP_593979.1| probable alpha-mannosidase [Schizos... 54 2e-05
gi|38104085|gb|EAA50705.1| hypothetical protein MG04464.4 [Magna... 54 2e-05
gi|41410219|ref|NP_963055.1| hypothetical protein MAP4121 [Mycob... 54 3e-05
gi|40748311|gb|AAR89631.1| putative alpha-mannosidase [Mycobacte... 54 3e-05
gi|21245094|ref|NP_640349.1| mannosidase, alpha, class 2C, membe... 54 3e-05
gi|50752648|ref|XP_413694.1| PREDICTED: similar to Alpha-mannosi... 53 6e-05
gi|16804054|ref|NP_465539.1| similar to alpha-mannosidase [Liste... 52 8e-05
gi|46852164|ref|NP_006706.2| mannosidase, alpha, class 2C, membe... 52 1e-04
gi|6136294|gb|AAC00190.2| alpha mannosidase 6A8B [Homo sapiens] 52 1e-04
gi|15840051|ref|NP_335088.1| glycosyl hydrolase, family 5 [Mycob... 52 1e-04
gi|26340104|dbj|BAC33715.1| unnamed protein product [Mus musculus] 51 2e-04
gi|30794150|ref|NP_082912.1| mannosidase, alpha, class 2C, membe... 51 2e-04
gi|21219466|ref|NP_625245.1| putative alpha-mannosidase [Strepto... 51 2e-04
gi|29828295|ref|NP_822929.1| putative alpha-mannosidase [Strepto... 51 2e-04
gi|46124907|ref|XP_387007.1| hypothetical protein FG06831.1 [Gib... 51 2e-04
gi|47096658|ref|ZP_00234245.1| alpha-D-mannosidase [Listeria mon... 50 3e-04
gi|46130042|ref|ZP_00164745.2| COG0383: Alpha-mannosidase [Synec... 50 5e-04
gi|50510719|dbj|BAD32345.1| mKIAA0935 protein [Mus musculus] 49 6e-04
gi|171057|gb|AAA34422.1| alpha-mannosidase >gnl|BL_ORD_ID|580849... 49 8e-04
gi|6321282|ref|NP_011359.1| vacuolar alpha mannosidase; Ams1p [S... 49 8e-04
gi|29726876|pdb|1O7D|C Chain C, The Structure Of The Bovine Lyso... 47 0.002
gi|14590701|ref|NP_142770.1| alpha-mannosidase [Pyrococcus horik... 47 0.002
gi|37519649|ref|NP_923026.1| putative alpha-mannosidase [Gloeoba... 47 0.003
gi|29833819|ref|NP_828453.1| putative alpha-mannosidase [Strepto... 47 0.003
gi|45201481|ref|NP_987051.1| AGR385Cp [Eremothecium gossypii] >g... 47 0.004
gi|50260228|gb|EAL22887.1| hypothetical protein CNBA6560 [Crypto... 46 0.007
gi|15921254|ref|NP_376923.1| 951aa long hypothetical alpha-manno... 46 0.007
gi|50842938|ref|YP_056165.1| alpha-mannosidase [Propionibacteriu... 45 0.016
gi|15899713|ref|NP_344318.1| Alpha-mannosidase [Sulfolobus solfa... 44 0.020
gi|45547617|ref|ZP_00187662.1| COG0383: Alpha-mannosidase [Rubro... 44 0.020
gi|48477163|ref|YP_022869.1| alpha-mannosidase [Picrophilus torr... 44 0.035
gi|16331225|ref|NP_441953.1| alpha-mannosidase [Synechocystis sp... 43 0.046
gi|47194663|emb|CAF88406.1| unnamed protein product [Tetraodon n... 43 0.060
gi|13541040|ref|NP_110728.1| Alpha-mannosidase [Thermoplasma vol... 42 0.078
gi|16128707|ref|NP_415260.1| putative sugar hydrolase [Escherich... 42 0.10
gi|24111992|ref|NP_706502.1| putative sugar hydrolase [Shigella ... 41 0.23
gi|28379933|ref|NP_786825.1| alpha-mannosidase (putative) [Lacto... 41 0.23
gi|33864803|ref|NP_896362.1| possible alpha mannosidase [Synecho... 40 0.30
gi|29726875|pdb|1O7D|B Chain B, The Structure Of The Bovine Lyso... 40 0.30
gi|49075752|ref|XP_401920.1| hypothetical protein UM04305.1 [Ust... 40 0.30
gi|29376259|ref|NP_815413.1| glycosyl hydrolase, family 38 [Ente... 40 0.39
gi|33864106|ref|NP_895666.1| Glycoside hydrolase family 38 [Proc... 40 0.50
gi|15673480|ref|NP_267654.1| sugar hydrolase [Lactococcus lactis... 39 0.86
gi|37677054|ref|NP_937450.1| alpha-mannosidase [Vibrio vulnificu... 37 2.5
gi|47091547|ref|ZP_00229344.1| glycosyl hydrolase, family 38 [Li... 37 3.3
gi|15964106|ref|NP_384459.1| PUTATIVE MALONIC SEMIALDEHYDE OXIDA... 37 4.3
gi|16799501|ref|NP_469769.1| highly similar to E. col YbgG prote... 36 5.6
gi|45201222|ref|NP_986792.1| AGR126Cp [Eremothecium gossypii] >g... 36 5.6
gi|24654717|ref|NP_728520.1| CG32343-PA [Drosophila melanogaster... 36 5.6
gi|16802446|ref|NP_463931.1| highly similar to E. col YbgG prote... 36 7.3
gi|29840580|ref|NP_829686.1| glycyl-tRNA synthetase, tetrameric ... 36 7.3
gi|23114856|ref|ZP_00100136.1| COG0747: ABC-type dipeptide trans... 36 7.3
gi|47096592|ref|ZP_00234181.1| glycosyl hydrolase, family 38 [Li... 36 7.3
gi|50408379|ref|XP_456775.1| unnamed protein product [Debaryomyc... 35 9.5
>gi|17561670|ref|NP_505995.1| alpha-mannosidase ii (5M408)
[Caenorhabditis elegans]
gi|7504686|pir||T22952 hypothetical protein F58H1.1 - Caenorhabditis
elegans
gi|3877892|emb|CAB00104.1| Hypothetical protein F58H1.1
[Caenorhabditis elegans]
Length = 1143
Score = 2251 bits (5832), Expect = 0.0
Identities = 1114/1143 (97%), Positives = 1114/1143 (97%)
Frame = -1
Query: 3432 MGKRNFYIILCLGVFLTVSLYLYNGIETGAEALTKRQANDLRRKIGNLEHVAEENGRTID 3253
MGKRNFYIILCLGVFLTVSLYLYNGIETGAEALTKRQANDLRRKIGNLEHVAEENGRTID
Sbjct: 1 MGKRNFYIILCLGVFLTVSLYLYNGIETGAEALTKRQANDLRRKIGNLEHVAEENGRTID 60
Query: 3252 RLEQEVQRAKAEKSVDFDXXXXXXXXXXXXXXXXXVAPVPVRGNRGEMAHIHQVKQHIKP 3073
RLEQEVQRAKAEKSVDFD VAPVPVRGNRGEMAHIHQVKQHIKP
Sbjct: 61 RLEQEVQRAKAEKSVDFDEEKEKTEEKEVEKEEKEVAPVPVRGNRGEMAHIHQVKQHIKP 120
Query: 3072 TPSMKDVCGIRENVSIAHSDLQMLDLYDTWKFENPDGGVWKQGWKIEYDAEKVKSLPRLE 2893
TPSMKDVCGIRENVSIAHSDLQMLDLYDTWKFENPDGGVWKQGWKIEYDAEKVKSLPRLE
Sbjct: 121 TPSMKDVCGIRENVSIAHSDLQMLDLYDTWKFENPDGGVWKQGWKIEYDAEKVKSLPRLE 180
Query: 2892 VIVIPHSHCDPGWIMTFEEYYNRQTRNILDGMAKHLAEKDEMRFIYAEISFFETWWRDQA 2713
VIVIPHSHCDPGWIMTFEEYYNRQTRNILDGMAKHLAEKDEMRFIYAEISFFETWWRDQA
Sbjct: 181 VIVIPHSHCDPGWIMTFEEYYNRQTRNILDGMAKHLAEKDEMRFIYAEISFFETWWRDQA 240
Query: 2712 DEIKKKVKGYLEAGKFEIVTGGWVMTDEANAHYHSMITELFEGHEWIQNHLGKSAIPQSH 2533
DEIKKKVKGYLEAGKFEIVTGGWVMTDEANAHYHSMITELFEGHEWIQNHLGKSAIPQSH
Sbjct: 241 DEIKKKVKGYLEAGKFEIVTGGWVMTDEANAHYHSMITELFEGHEWIQNHLGKSAIPQSH 300
Query: 2532 WSIDPFGLSPSMPHLLTSANITNAVIQRVHYSVKRELALKKNLEFYWRQLFGSTGHPDLR 2353
WSIDPFGLSPSMPHLLTSANITNAVIQRVHYSVKRELALKKNLEFYWRQLFGSTGHPDLR
Sbjct: 301 WSIDPFGLSPSMPHLLTSANITNAVIQRVHYSVKRELALKKNLEFYWRQLFGSTGHPDLR 360
Query: 2352 SHIMPFYSYDIPHTCGPEPSVCCQFDFRRMPEGGKSCDWGIPPQKINDDNVAHRAEMIYD 2173
SHIMPFYSYDIPHTCGPEPSVCCQFDFRRMPEGGKSCDWGIPPQKINDDNVAHRAEMIYD
Sbjct: 361 SHIMPFYSYDIPHTCGPEPSVCCQFDFRRMPEGGKSCDWGIPPQKINDDNVAHRAEMIYD 420
Query: 2172 QYRKKSQLFKNNVIFQPLGDDFRYDIDFEWNSQYENYKKLFEYMNSKSEWNVHAQFGTLS 1993
QYRKKSQLFKNNVIFQPLGDDFRYDIDFEWNSQYENYKKLFEYMNSKSEWNVHAQFGTLS
Sbjct: 421 QYRKKSQLFKNNVIFQPLGDDFRYDIDFEWNSQYENYKKLFEYMNSKSEWNVHAQFGTLS 480
Query: 1992 DYFKKLDTAISASGEQLPTFSGDFFTYADRDDHYWSGYFTSRPFYKQLDRVLQHYLRSAE 1813
DYFKKLDTAISASGEQLPTFSGDFFTYADRDDHYWSGYFTSRPFYKQLDRVLQHYLRSAE
Sbjct: 481 DYFKKLDTAISASGEQLPTFSGDFFTYADRDDHYWSGYFTSRPFYKQLDRVLQHYLRSAE 540
Query: 1812 IAFTLANIEEEGMVEAKIFEKLVTARRALSLFQHHDGVTGTAKDHVVLDYGQKMIDALNA 1633
IAFTLANIEEEGMVEAKIFEKLVTARRALSLFQHHDGVTGTAKDHVVLDYGQKMIDALNA
Sbjct: 541 IAFTLANIEEEGMVEAKIFEKLVTARRALSLFQHHDGVTGTAKDHVVLDYGQKMIDALNA 600
Query: 1632 CEDILSEALVVLLGIDSTNKMQMDEHRVNENLLPEKRVYKIGQNVVLFNTLSRNRNEPIC 1453
CEDILSEALVVLLGIDSTNKMQMDEHRVNENLLPEKRVYKIGQNVVLFNTLSRNRNEPIC
Sbjct: 601 CEDILSEALVVLLGIDSTNKMQMDEHRVNENLLPEKRVYKIGQNVVLFNTLSRNRNEPIC 660
Query: 1452 IQVDSLDAGVEADPPIKKQQVSPVIAYDEEKKTLVVKNGIFELCFMLSLGPMESVSFRLV 1273
IQVDSLDAGVEADPPIKKQQVSPVIAYDEEKKTLVVKNGIFELCFMLSLGPMESVSFRLV
Sbjct: 661 IQVDSLDAGVEADPPIKKQQVSPVIAYDEEKKTLVVKNGIFELCFMLSLGPMESVSFRLV 720
Query: 1272 KNTTTSKVEIITNNAAXXXXXXXXXXXXSGDFTVKNDKVEAEFDGENGMIKRATSLVDDK 1093
KNTTTSKVEIITNNAA SGDFTVKNDKVEAEFDGENGMIKRATSLVDDK
Sbjct: 721 KNTTTSKVEIITNNAAEFKETSFKSSSTSGDFTVKNDKVEAEFDGENGMIKRATSLVDDK 780
Query: 1092 PIDLNSHFIHYGARKSKRKFANGNEDNPAGAYLFLPDGEARELKKQSSDWILVKGEVVQK 913
PIDLNSHFIHYGARKSKRKFANGNEDNPAGAYLFLPDGEARELKKQSSDWILVKGEVVQK
Sbjct: 781 PIDLNSHFIHYGARKSKRKFANGNEDNPAGAYLFLPDGEARELKKQSSDWILVKGEVVQK 840
Query: 912 VFATPNNDLKILQTYTLYQGLPWIDLDNEVDVRSKENFELALRFSSSVNSGDEFFTDLNG 733
VFATPNNDLKILQTYTLYQGLPWIDLDNEVDVRSKENFELALRFSSSVNSGDEFFTDLNG
Sbjct: 841 VFATPNNDLKILQTYTLYQGLPWIDLDNEVDVRSKENFELALRFSSSVNSGDEFFTDLNG 900
Query: 732 MQMIKRRRQTKLPTQANFYPMSAGVYIEDDTTRMSIHSAQALGVSSLSSGQIEIMLDRRL 553
MQMIKRRRQTKLPTQANFYPMSAGVYIEDDTTRMSIHSAQALGVSSLSSGQIEIMLDRRL
Sbjct: 901 MQMIKRRRQTKLPTQANFYPMSAGVYIEDDTTRMSIHSAQALGVSSLSSGQIEIMLDRRL 960
Query: 552 SSDDNRGLQQGVRDNKRTVAHFRIVIEPMSSSSGNKKEERVGFHSHVGHLATWSLHYPLV 373
SSDDNRGLQQGVRDNKRTVAHFRIVIEPMSSSSGNKKEERVGFHSHVGHLATWSLHYPLV
Sbjct: 961 SSDDNRGLQQGVRDNKRTVAHFRIVIEPMSSSSGNKKEERVGFHSHVGHLATWSLHYPLV 1020
Query: 372 KMIGDATPKSISSKNVEQELNCDLHLVTFRTLASPTTYEANERSTAAEKKAAMVMHRVVP 193
KMIGDATPKSISSKNVEQELNCDLHLVTFRTLASPTTYEANERSTAAEKKAAMVMHRVVP
Sbjct: 1021 KMIGDATPKSISSKNVEQELNCDLHLVTFRTLASPTTYEANERSTAAEKKAAMVMHRVVP 1080
Query: 192 DCRSRLTLPDTSCLATGLEIEPLKLISTLKSAKKTSLTNLYEGNKAEQFRLQPNDISSIL 13
DCRSRLTLPDTSCLATGLEIEPLKLISTLKSAKKTSLTNLYEGNKAEQFRLQPNDISSIL
Sbjct: 1081 DCRSRLTLPDTSCLATGLEIEPLKLISTLKSAKKTSLTNLYEGNKAEQFRLQPNDISSIL 1140
Query: 12 VSF 4
VSF
Sbjct: 1141 VSF 1143
>gi|39592130|emb|CAE75350.1| Hypothetical protein CBG23330
[Caenorhabditis briggsae]
Length = 1146
Score = 2021 bits (5236), Expect = 0.0
Identities = 975/1147 (85%), Positives = 1067/1147 (93%), Gaps = 4/1147 (0%)
Frame = -1
Query: 3432 MGKRNFYIILCLGVFLTVSLYLYNGIETGAEALTKRQ--ANDLRRKIGNLEHVAEENGRT 3259
MGKRNFYIIL LGVFLTVSLYLYNGIETGAEA+ KRQ +DLRRKIGNLEHVAEENGRT
Sbjct: 1 MGKRNFYIILSLGVFLTVSLYLYNGIETGAEAIAKRQQYVDDLRRKIGNLEHVAEENGRT 60
Query: 3258 IDRLEQEVQRAKAEKSVDFDXXXXXXXXXXXXXXXXXV-APVPVRGNRGEMAHIHQVKQH 3082
IDRLEQ+V++AK EKSVDFD APVPVRGNRGE+AH+HQV++H
Sbjct: 61 IDRLEQQVRQAKFEKSVDFDEEKEKTEEKEQVREQEKEVAPVPVRGNRGELAHVHQVQKH 120
Query: 3081 IKPTPSMKDVCGIRENVSIAHSDLQMLDLYDTWKFENPDGGVWKQGWKIEYDAEKVKSLP 2902
I+PTP M DVCG+REN+S HSDLQMLDLYD WKFENPDGGVWKQGWKIEYD+EKVKS+P
Sbjct: 121 IRPTPPMADVCGLRENISAPHSDLQMLDLYDIWKFENPDGGVWKQGWKIEYDSEKVKSIP 180
Query: 2901 RLEVIVIPHSHCDPGWIMTFEEYYNRQTRNILDGMAKHLAEKDEMRFIYAEISFFETWWR 2722
RLEV+VIPHSHCDPGWIMTF+EYYNRQTRNILDGMAKHL EKDEMRFIYAEISFFETWWR
Sbjct: 181 RLEVVVIPHSHCDPGWIMTFDEYYNRQTRNILDGMAKHLGEKDEMRFIYAEISFFETWWR 240
Query: 2721 DQADEIKKKVKGYLEAGKFEIVTGGWVMTDEANAHYHSMITELFEGHEWIQNHLGKSAIP 2542
DQ++EI+KKVKGYLEAGK EIVTGGWVMTDEANAHY+SM+TELFEGHEWIQNHLGK AIP
Sbjct: 241 DQSEEIRKKVKGYLEAGKLEIVTGGWVMTDEANAHYYSMVTELFEGHEWIQNHLGKKAIP 300
Query: 2541 QSHWSIDPFGLSPSMPHLLTSANITNAVIQRVHYSVKRELALKKNLEFYWRQLFGSTGHP 2362
++HWSIDPFGLSPS+PHLLTSANITNAV+QRVHYSVKRELALKKNLEFYWRQLFGSTG+P
Sbjct: 301 KAHWSIDPFGLSPSLPHLLTSANITNAVLQRVHYSVKRELALKKNLEFYWRQLFGSTGYP 360
Query: 2361 DLRSHIMPFYSYDIPHTCGPEPSVCCQFDFRRMPEGGKSCDWGIPPQKINDDNVAHRAEM 2182
D RSHIMPFYSYDIPHTCGPEPSVCCQFDFRRMPEGGKSCDWGIPPQKI D+NVA RA+M
Sbjct: 361 DFRSHIMPFYSYDIPHTCGPEPSVCCQFDFRRMPEGGKSCDWGIPPQKITDENVAQRAQM 420
Query: 2181 IYDQYRKKSQLFKNNVIFQPLGDDFRYDIDFEWNSQYENYKKLFEYMNSKSEWNVHAQFG 2002
IYDQYRKKSQLFKN+VIFQPLGDDFRYDI+FEWNSQYENYKKLFEYMNSK EWNVHAQFG
Sbjct: 421 IYDQYRKKSQLFKNSVIFQPLGDDFRYDIEFEWNSQYENYKKLFEYMNSKPEWNVHAQFG 480
Query: 2001 TLSDYFKKLDTAISA-SGEQLPTFSGDFFTYADRDDHYWSGYFTSRPFYKQLDRVLQHYL 1825
TLSDYFKKLD AIS+ SGE+LPT SGDFFTYADRDDHYWSGYFTSRPFYKQLDRVLQHYL
Sbjct: 481 TLSDYFKKLDAAISSESGEKLPTLSGDFFTYADRDDHYWSGYFTSRPFYKQLDRVLQHYL 540
Query: 1824 RSAEIAFTLANIEEEGMVEAKIFEKLVTARRALSLFQHHDGVTGTAKDHVVLDYGQKMID 1645
RSAEIAF+LAN+EEEGM++AK+FEKLVTARRALSLFQHHDGVTGTAKDHVVLDYGQKMID
Sbjct: 541 RSAEIAFSLANVEEEGMMDAKVFEKLVTARRALSLFQHHDGVTGTAKDHVVLDYGQKMID 600
Query: 1644 ALNACEDILSEALVVLLGIDSTNKMQMDEHRVNENLLPEKRVYKIGQNVVLFNTLSRNRN 1465
ALNACE++LSE+L+VLLGIDST KM MDE RVNENLLPEKRVYK+GQNVVLFNTLSRNRN
Sbjct: 601 ALNACEEVLSESLIVLLGIDSTQKMGMDEKRVNENLLPEKRVYKVGQNVVLFNTLSRNRN 660
Query: 1464 EPICIQVDSLDAGVEADPPIKKQQVSPVIAYDEEKKTLVVKNGIFELCFMLSLGPMESVS 1285
EPICIQVDS+DAG+EADPPI KQQ+SPV+ Y+EE K LVVK G+FELCF +S+GPMES+S
Sbjct: 661 EPICIQVDSVDAGIEADPPITKQQISPVLQYNEEIKKLVVKEGVFELCFAVSMGPMESMS 720
Query: 1284 FRLVKNTTTSKVEIITNNAAXXXXXXXXXXXXSGDFTVKNDKVEAEFDGENGMIKRATSL 1105
+LVK+TTT+K EI T ++ SGDFTV+NDKV+AEFDGENGMIK+ATSL
Sbjct: 721 LKLVKSTTTTKSEIRT-HSDLKFDSNFKSSSTSGDFTVENDKVKAEFDGENGMIKKATSL 779
Query: 1104 VDDKPIDLNSHFIHYGARKSKRKFANGNEDNPAGAYLFLPDGEARELKKQSSDWILVKGE 925
VD+K I+LNSH++HYGARK++RKFANGNEDNPAGAYLFLPDGEARELKKQ SDW++V+G+
Sbjct: 780 VDNKSIELNSHYVHYGARKARRKFANGNEDNPAGAYLFLPDGEARELKKQESDWVVVEGD 839
Query: 924 VVQKVFATPNNDLKILQTYTLYQGLPWIDLDNEVDVRSKENFELALRFSSSVNSGDEFFT 745
VV+KVF TP NDLKILQTYTLYQGLPWIDLDNEVDVRSKENFELALRFS+SV+SGDEFFT
Sbjct: 840 VVRKVFTTPINDLKILQTYTLYQGLPWIDLDNEVDVRSKENFELALRFSTSVSSGDEFFT 899
Query: 744 DLNGMQMIKRRRQTKLPTQANFYPMSAGVYIEDDTTRMSIHSAQALGVSSLSSGQIEIML 565
DLNGMQMIKRRRQ KLPTQANFYPMSAGVYIED+ TR++IHSAQALGVSSLSSGQIEIML
Sbjct: 900 DLNGMQMIKRRRQAKLPTQANFYPMSAGVYIEDEATRLTIHSAQALGVSSLSSGQIEIML 959
Query: 564 DRRLSSDDNRGLQQGVRDNKRTVAHFRIVIEPMSSSSGNKKEERVGFHSHVGHLATWSLH 385
DRRLSSDDNRGLQQGVRDNKRTVAHFRIV EPMS + NKKEERVGFHSHVGHLATWSLH
Sbjct: 960 DRRLSSDDNRGLQQGVRDNKRTVAHFRIVAEPMSPGASNKKEERVGFHSHVGHLATWSLH 1019
Query: 384 YPLVKMIGDATPKSISSKNVEQELNCDLHLVTFRTLASPTTYEANERSTAAEKKAAMVMH 205
YP++KM+G+ TPK ISSKNVEQELNCDLH+VTFR+LASPTTYEANERSTAAEKKAAMVMH
Sbjct: 1020 YPVIKMMGETTPKPISSKNVEQELNCDLHMVTFRSLASPTTYEANERSTAAEKKAAMVMH 1079
Query: 204 RVVPDCRSRLTLPDTSCLATGLEIEPLKLISTLKSAKKTSLTNLYEGNKAEQFRLQPNDI 25
RVVPDCRSRLTLP+TSCL +GLEIEPLKLISTLKSA++T+LTNLYEG ++E+F+LQPND+
Sbjct: 1080 RVVPDCRSRLTLPNTSCLLSGLEIEPLKLISTLKSARQTTLTNLYEGQESEEFKLQPNDV 1139
Query: 24 SSILVSF 4
SSILVSF
Sbjct: 1140 SSILVSF 1146
>gi|49117994|gb|AAH72937.1| Unknown (protein for MGC:80473) [Xenopus
laevis]
Length = 1150
Score = 728 bits (1879), Expect = 0.0
Identities = 415/1072 (38%), Positives = 622/1072 (57%), Gaps = 48/1072 (4%)
Frame = -1
Query: 3075 PTPSMKDVCGIRENVSIAH----SDLQMLDLYDTWKFENPDGGVWKQGWKIEYDAEKVKS 2908
P PS V S+A+ +DLQM+D+Y F+N DGGVWKQG+ I YD ++ +
Sbjct: 104 PRPSFYSVSPQDCQFSVANKRQKTDLQMIDVYAQLPFDNVDGGVWKQGFDITYDPKEWDN 163
Query: 2907 LPRLEVIVIPHSHCDPGWIMTFEEYYNRQTRNILDGMAKHLAEKDEMRFIYAEISFFETW 2728
P L+V V+PHSH DPGWI TF++YY QT++IL+ M L E +FI++EISFF W
Sbjct: 164 EP-LQVFVVPHSHNDPGWIKTFDKYYYDQTQHILNNMLVKLHEDPRRKFIWSEISFFSKW 222
Query: 2727 WRDQADEIKKKVKGYLEAGKFEIVTGGWVMTDEANAHYHSMITELFEGHEWIQNHLGKSA 2548
W + + + V+ + +G+ E+ TGGWVM DEAN HY +MI ++ EGH+W++ ++
Sbjct: 223 WDNINSQKRAAVRRLVASGQLEMTTGGWVMPDEANTHYFAMIDQMIEGHQWLKKNI--DV 280
Query: 2547 IPQSHWSIDPFGLSPSMPHLLTSANITNAVIQRVHYSVKRELALKKNLEFYWRQLFGSTG 2368
P+S W++DPFG S +MP++L +N+T+ +IQRVHYS+K+ A ++LEF WRQ +
Sbjct: 281 TPRSGWAVDPFGHSSTMPYILRLSNLTSMLIQRVHYSIKKHFAATQSLEFMWRQTWDPDS 340
Query: 2367 HPDLRSHIMPFYSYDIPHTCGPEPSVCCQFDFRRMPEGGKSCDWGIPPQKINDDNVAHRA 2188
D+ H+MPFYSYD+PHTCGP+P +CCQFDFRR+P G +C W +PP+ I D N+A RA
Sbjct: 341 STDIFCHMMPFYSYDVPHTCGPDPKICCQFDFRRLPGGRINCPWKVPPRAITDSNLAERA 400
Query: 2187 EMIYDQYRKKSQLFKNNVIFQPLGDDFRYDIDFEWNSQYENYKKLFEYMNSKSEWNVHAQ 2008
++ DQY+KKS+L+++ V+ PLGDDFRYD EW++Q+ NY+KLF+YMNS E +V AQ
Sbjct: 401 IILLDQYKKKSKLYRSKVVLVPLGDDFRYDKIQEWDAQFLNYQKLFDYMNSHPELHVQAQ 460
Query: 2007 FGTLSDYF----KKLDTAISASGEQLPTFSGDFFTYADRDDHYWSGYFTSRPFYKQLDRV 1840
FGTLSDYF K++ + P SGDFF+YADR+DHYW+GY+TSRPFYK +DRV
Sbjct: 461 FGTLSDYFDALYKRMGVSPGMKPPDFPVVSGDFFSYADREDHYWTGYYTSRPFYKSMDRV 520
Query: 1839 LQHYLRSAEIAFTLA-NIEEEGMVEAKI----FEKLVTARRALSLFQHHDGVTGTAKDHV 1675
L+ +LR AEI ++LA N + +E+K + L ARR L LFQHHD +TGTAK+ V
Sbjct: 521 LESHLRGAEILYSLAINHARKAGMESKYPLSDYALLTDARRNLGLFQHHDAITGTAKEAV 580
Query: 1674 VLDYGQKMIDALNACEDILSEALVVLLGID--------STNKMQMDEHRVNENLLPEKRV 1519
V+DYG +++ +L + I+ A L+ D S DE R+ + LPEK V
Sbjct: 581 VIDYGVRLLHSLMNLKRIIINAAHYLVVADKEKYHYDHSVPFFSTDESRLTQESLPEKTV 640
Query: 1518 YKIGQN---VVLFNTLSRNRNEPICIQVDSLDAGV--EADPPIKKQQVSPVIAYDEEKKT 1354
K+ + V++FN + +NR + + V++ + V E P+ Q+SPV +
Sbjct: 641 IKLSTSPRYVLVFNPVEQNRLCVVSLLVNTYNVRVLTEDGQPV-AAQLSPV-----WQSV 694
Query: 1353 LVVKNGIFELCFMLSLGPMESVSFRL-----VKNTTTSKVEIITNNAAXXXXXXXX---- 1201
+ ++++ F + L + F+L T S V + +
Sbjct: 695 TDMNPDVYQVSFTVRLPSLGLSIFQLYASIDTHTTLKSNVRVYLHGRELTIKKQDAFPVK 754
Query: 1200 -XXXXSGDFTVKNDKVEAEFDGENGMIKRATSLVDDKPIDLNSHFIHYGARKSKRKFANG 1024
+ DF ++N ++ F G G++K +++ +N+ F+ YG R SK K
Sbjct: 755 VLESNTDDFYIENQYMQVWFSGTTGLLKSIKRAGEEQEQKINTQFLIYGTRTSKDK---- 810
Query: 1023 NEDNPAGAYLFLPDGEARELKKQSSDWILV-KGEVVQKVFATPNNDLKILQTYTL--YQG 853
+GAYLFLPDGE + + + V +G +V + ++++ Y L +G
Sbjct: 811 -----SGAYLFLPDGEGKPYTPKDPPVVRVTEGPFFSEVTCQYQHVQQVMRLYNLPGTEG 865
Query: 852 LPWIDLDNEVDVRSKENFELALRFSSSVNSGDEFFTDLNGMQMIKRRRQTKLPTQANFYP 673
L +D+ +D+R N E+A+R S+ + SGD FFTDLNG Q+ R+ KLP QANFYP
Sbjct: 866 LS-LDISLLIDIRDHVNKEIAMRLSTDIQSGDTFFTDLNGFQIQPRKFFKKLPLQANFYP 924
Query: 672 MSAGVYIEDDTTRMSIHSAQALGVSSLSSGQIEIMLDRRLSSDDNRGLQQGVRDNKRTVA 493
M YI+D+ R+++H+AQALGVSSL +G++E++LDRRL DDNRGL QG++DNKR +
Sbjct: 925 MPTMAYIQDEQNRLTLHTAQALGVSSLKNGELEVILDRRLMQDDNRGLGQGLKDNKRLCS 984
Query: 492 HFRIVIEPMSSSSGNKKEERVGFHSHVGHLATWSL-HYPLVKMI-GDATPKSISSKNVEQ 319
FRI++E S + + + V F S + H+ + L H PL+ + + P S + +
Sbjct: 985 RFRILMEKRSPVNKSLGNQLVSFPSLLSHMTSMHLNHDPLLMAVTNEKGPVLKSFQPLSA 1044
Query: 318 ELNCDLHLVTFRTLASPTTYEANERSTAAEKKAAMVMHRVVPDCRSRLTLPDTSCLAT-- 145
L CD H++ RTL + E A+++HR DC +C +
Sbjct: 1045 TLPCDFHILNLRTLQA-------EDDGLPSPDMALILHRKGFDCGLEAKNLAFNCTTSQG 1097
Query: 144 GLEIEPLKLISTLKSAKKTSLTNLY-----EGNKAEQFRLQPNDISSILVSF 4
L + L L + + ++TSLT +Y N + P +IS+ + F
Sbjct: 1098 KLSLGGLFLGLDIGTVQQTSLTLMYSLASPSNNSNPTVSMDPMEISTYRLRF 1149
>gi|3122380|sp|Q16706|M2A1_HUMAN Alpha-mannosidase II
(Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase) (MAN
II) (Golgi alpha-mannosidase II) (Mannosidase alpha class
2A member 1)
gi|1117827|gb|AAC50302.1| alpha mannosidase II
Length = 1144
Score = 724 bits (1868), Expect = 0.0
Identities = 420/1150 (36%), Positives = 646/1150 (55%), Gaps = 45/1150 (3%)
Frame = -1
Query: 3324 QANDLRRKIGNLEHVAEENGRTIDRLEQEVQRAKAEKSVDFDXXXXXXXXXXXXXXXXXV 3145
Q + L+ KI +LE + EN I + V +SV+
Sbjct: 47 QLSMLQEKIDHLERLLAENNEIISNIRDSV--INLSESVE-------------------D 85
Query: 3144 APVPVRGNRGEMAHIHQVKQHIKPTPSMKDVCGIRENVSIAHSDLQMLDLYDTWKFENPD 2965
P + N + A H + + + D C +SD+QMLD+Y F+NPD
Sbjct: 86 GPKSSQSNFSQGAGSHLLPSQLSLSVDTAD-CLFASQSGSHNSDVQMLDVYSLISFDNPD 144
Query: 2964 GGVWKQGWKIEYDAEKVKSLPRLEVIVIPHSHCDPGWIMTFEEYYNRQTRNILDGMAKHL 2785
GGVWKQG+ I Y++ + + P L+V V+PHSH DPGW+ TF +Y+ +T+ I + M L
Sbjct: 145 GGVWKQGFDITYESNEWDTEP-LQVFVVPHSHNDPGWLKTFNDYFRDKTQYIFNNMVLKL 203
Query: 2784 AEKDEMRFIYAEISFFETWWRDQADEIKKKVKGYLEAGKFEIVTGGWVMTDEANAHYHSM 2605
E +FI++EIS+ WW + K VK +E G+ EIVTGGWVM DEA HY ++
Sbjct: 204 KEDSRRKFIWSEISYLSKWWDIIDIQKKDAVKSLIENGQLEIVTGGWVMPDEATPHYFAL 263
Query: 2604 ITELFEGHEWIQNHLGKSAIPQSHWSIDPFGLSPSMPHLLTSANITNAVIQRVHYSVKRE 2425
I +L EGH+W++N++G P+S W+IDPFG SP+M +LL A +++ +IQRVHY+VK+
Sbjct: 264 IDQLIEGHQWLENNIGVK--PRSGWAIDPFGHSPTMAYLLNRAGLSHMLIQRVHYAVKKH 321
Query: 2424 LALKKNLEFYWRQLFGSTGHPDLRSHIMPFYSYDIPHTCGPEPSVCCQFDFRRMPEGGKS 2245
AL K LEF+WRQ + D+ H+MPFYSYDIPHTCGP+P +CCQFDF+R+P G
Sbjct: 322 FALHKTLEFFWRQNWDLGSVTDILCHMMPFYSYDIPHTCGPDPKICCQFDFKRLPGGRFG 381
Query: 2244 CDWGIPPQKINDDNVAHRAEMIYDQYRKKSQLFKNNVIFQPLGDDFRYDIDFEWNSQYEN 2065
C WG+PP+ I+ NV RA M+ DQYRKKS+LF+ V+ PLGDDFRY EW+ Q++N
Sbjct: 382 CPWGVPPETIHPGNVQSRARMLLDQYRKKSKLFRTKVLLAPLGDDFRYCEYTEWDLQFKN 441
Query: 2064 YKKLFEYMNSKSEWNVHAQFGTLSDYFKKLDTAISASGEQ----LPTFSGDFFTYADRDD 1897
Y++LF+YMNS+S++ V QFGTLSD+F LD A ++ P SGDFFTYADRDD
Sbjct: 442 YQQLFDYMNSQSKFKVKIQFGTLSDFFDALDKADETQRDKGQSMFPVLSGDFFTYADRDD 501
Query: 1896 HYWSGYFTSRPFYKQLDRVLQHYLRSAEIAFTLA-----NIEEEGMVEAKIFEKLVTARR 1732
HYWSGYFTSRPFYK++DR+++ +LR+AEI + A + + + ++ L ARR
Sbjct: 502 HYWSGYFTSRPFYKRMDRIMESHLRAAEILYYFALRQAHKYKINKFLSSSLYTALTEARR 561
Query: 1731 ALSLFQHHDGVTGTAKDHVVLDYGQKMIDALNACEDILSEALVVLLGIDSTNK------- 1573
L LFQHHD +TGTAKD VV+DYG ++ +L E I+ + +L+G D
Sbjct: 562 NLGLFQHHDAITGTAKDWVVVDYGTRLFHSLMVLEKIIGNSAFLLIGKDKLTYDSYSPDT 621
Query: 1572 -MQMDEHRVNENLLPEKRVYKIG---QNVVLFNTLSRNRNEPICIQVDSLDAGV-EADPP 1408
++MD + +++ LP+K + ++ + +V++N L ++R + + V S V A
Sbjct: 622 FLEMDLKQKSQDSLPQKNIIRLSAEPRYLVVYNPLEQDRISLVSVYVSSPTVQVFSASGK 681
Query: 1407 IKKQQVSPVIAYDEEKKTLVVKNGIFELCFMLSLGPMESVSFRLVKNTTTSKVEIITNNA 1228
+ QVS V +D + +E+ F + P+ ++++++ + +N+
Sbjct: 682 PVEVQVSAV--WDTAN---TISETAYEISFRAHIPPLGLKVYKILESAS-------SNSH 729
Query: 1227 AXXXXXXXXXXXXSGDFTVK------------NDKVEAEFDGENGMIKRATSLVDDKPID 1084
SG FT+K N V FD + G++K+ + D K +
Sbjct: 730 LADYVLYKNKVEDSGIFTIKNMINTEEGITLENSFVLLRFD-QTGLMKQMMTKEDGKHHE 788
Query: 1083 LNSHFIHYGARKSKRKFANGNEDNPAGAYLFLPDGEARELKKQSSDWILV-KGEVVQKVF 907
+N F YG + K +GAYLFLPDG A+ + ++ V G + +V
Sbjct: 789 VNVQFSWYGTTIKRDK---------SGAYLFLPDGNAKPYVYTTPPFVRVTHGRIYSEVT 839
Query: 906 ATPNNDLKILQTYTLYQGLPW--IDLDNEVDVRSKENFELALRFSSSVNSGDEFFTDLNG 733
++ ++ Y + QG+ +++ N VD+R N E+A++ SS + S + F+TDLNG
Sbjct: 840 CFFDHVTHRVRLYHI-QGIEGQSVEVSNIVDIRKVYNREIAMKISSDIKSQNRFYTDLNG 898
Query: 732 MQMIKRRRQTKLPTQANFYPMSAGVYIEDDTTRMSIHSAQALGVSSLSSGQIEIMLDRRL 553
Q+ R +KLP QAN YPM+ YI+D R+++ SAQ+LGVSSL+SGQIE+++DRRL
Sbjct: 899 YQIQPRMTLSKLPLQANVYPMTTMAYIQDAKHRLTLLSAQSLGVSSLNSGQIEVIMDRRL 958
Query: 552 SSDDNRGLQQGVRDNKRTVAHFRIVIEPMSSSSGNKKEERVGFHSHVGHLATWSLHYPLV 373
DDNRGL+QG++DNK T FRI++E S+ + ++++ V + S + H+ + +++P++
Sbjct: 959 MQDDNRGLEQGIQDNKITANLFRILLEKRSAVNTEEEKKSVSYPSLLSHITSSLMNHPVI 1018
Query: 372 KMIGDATPKSISSKN----VEQELNCDLHLVTFRTLASPTTYEANERSTAAEKKAAMVMH 205
M + ++ + ++ L CD+HLV RT+ S +AA+++H
Sbjct: 1019 PMANKFSSPTLELQGEFSPLQSSLPCDIHLVNLRTIQSKV-------GNGHSNEAALILH 1071
Query: 204 RVVPDCRSRLTLPDTSCLATGLEIEPLKLIS--TLKSAKKTSLTNLYE---GNKAEQFRL 40
R DCR C T +I KL++ ++S +SL+ ++ + L
Sbjct: 1072 RKGFDCRFSSKGTGLFCSTTQGKILVQKLLNKFIVESLTPSSLSLMHSPPGTQNISEINL 1131
Query: 39 QPNDISSILV 10
P +IS+ +
Sbjct: 1132 SPMEISTFRI 1141
>gi|4758698|ref|NP_002363.1| mannosidase, alpha, class 2A, member 1;
mannosidase, alpha type II [Homo sapiens]
gi|974734|dbj|BAA10017.1| golgi alpha-mannosidaseII [Homo sapiens]
Length = 1143
Score = 719 bits (1857), Expect = 0.0
Identities = 420/1149 (36%), Positives = 643/1149 (55%), Gaps = 44/1149 (3%)
Frame = -1
Query: 3324 QANDLRRKIGNLEHVAEENGRTIDRLEQEVQRAKAEKSVDFDXXXXXXXXXXXXXXXXXV 3145
Q + L+ KI +LE + EN I + V +SV+
Sbjct: 47 QLSMLQEKIDHLERLLAENNEIISNIRDSV--INLSESVE-------------------D 85
Query: 3144 APVPVRGNRGEMAHIHQVKQHIKPTPSMKDVCGIRENVSIAHSDLQMLDLYDTWKFENPD 2965
P + N + A H + + + D C +SD+QMLD+Y F+NPD
Sbjct: 86 GPKSSQSNFSQGAGSHLLPSQLSLSVDTAD-CLFASQSGSHNSDVQMLDVYSLISFDNPD 144
Query: 2964 GGVWKQGWKIEYDAEKVKSLPRLEVIVIPHSHCDPGWIMTFEEYYNRQTRNILDGMAKHL 2785
GGVWKQG+ I Y++ + + P L+V V+PHSH DPGW+ TF +Y+ +T+ I + M L
Sbjct: 145 GGVWKQGFDITYESNEWDTEP-LQVFVVPHSHNDPGWLKTFNDYFRDKTQYIFNNMVLKL 203
Query: 2784 AEKDEMRFIYAEISFFETWWRDQADEIKKKVKGYLEAGKFEIVTGGWVMTDEANAHYHSM 2605
E +FI++EIS+ WW + K VK +E G+ EIVTGGWVM DEA HY ++
Sbjct: 204 KEDSRRKFIWSEISYLSKWWDIIDIQKKDAVKSLIENGQLEIVTGGWVMPDEATPHYFAL 263
Query: 2604 ITELFEGHEWIQNHLGKSAIPQSHWSIDPFGLSPSMPHLLTSANITNAVIQRVHYSVKRE 2425
I +L EGH+W++N++G P+S W+IDPFG SP+M +LL A +++ +IQRVHY+VK+
Sbjct: 264 IDQLIEGHQWLENNIGVK--PRSGWAIDPFGHSPTMAYLLNRAGLSHMLIQRVHYAVKKH 321
Query: 2424 LALKKNLEFYWRQLFGSTGHPDLRSHIMPFYSYDIPHTCGPEPSVCCQFDFRRMPEGGKS 2245
AL K LEF+WRQ + D+ H+MPFYSYDIPHTCGP+P +CCQFDF+R+P G
Sbjct: 322 FALHKTLEFFWRQNWDLGSVTDILCHMMPFYSYDIPHTCGPDPKICCQFDFKRLPGGRFG 381
Query: 2244 CDWGIPPQKINDDNVAHRAEMIYDQYRKKSQLFKNNVIFQPLGDDFRYDIDFEWNSQYEN 2065
C WG+PP+ I+ NV RA M+ DQYRKKS+LF+ V+ PLGDDFRY EW+ Q++N
Sbjct: 382 CPWGVPPETIHPGNVQSRARMLLDQYRKKSKLFRTKVLLAPLGDDFRYCEYTEWDLQFKN 441
Query: 2064 YKKLFEYMNSKSEWNVHAQFGTLSDYFKKLDTAISASGEQ----LPTFSGDFFTYADRDD 1897
Y++LF+YMNS+S++ V QFGTLSD+F LD A ++ P SGDFFTYADRDD
Sbjct: 442 YQQLFDYMNSQSKFKVKIQFGTLSDFFDALDKADETQRDKGQSMFPVLSGDFFTYADRDD 501
Query: 1896 HYWSGYFTSRPFYKQLDRVLQHYLRSAEIAFTLA-----NIEEEGMVEAKIFEKLVTARR 1732
HYWSGYFTSRPFYK++DR+++ +LR+AEI + A + + + ++ L ARR
Sbjct: 502 HYWSGYFTSRPFYKRMDRIMESHLRAAEILYYFALRQAHKYKINKFLSSSLYTALTEARR 561
Query: 1731 ALSLFQHHDGVTGTAKDHVVLDYGQKMIDALNACEDILSEALVVLLGIDSTNK------- 1573
L LFQHHD +TGTAKD VV+DYG ++ +L E I+ + +L+ D
Sbjct: 562 NLGLFQHHDAITGTAKDWVVVDYGTRLFHSLMVLEKIIGNSAFLLILKDKLTYDSYSPDT 621
Query: 1572 -MQMDEHRVNENLLPEKRVYKIG---QNVVLFNTLSRNRNEPICIQVDSLDAGV-EADPP 1408
++MD + +++ LP+K + ++ + +V++N L ++R + + V S V A
Sbjct: 622 FLEMDLKQKSQDSLPQKNIIRLSAEPRYLVVYNPLEQDRISLVSVYVSSPTVQVFSASGK 681
Query: 1407 IKKQQVSPVIAYDEEKKTLVVKNGIFELCFMLSLGPMESVSFRLVKNTTTSKVEIITNNA 1228
+ QVS V +D + +E+ F + P+ ++++++ + +N+
Sbjct: 682 PVEVQVSAV--WDTAN---TISETAYEISFRAHIPPLGLKVYKILESAS-------SNSH 729
Query: 1227 AXXXXXXXXXXXXSGDFTVK------------NDKVEAEFDGENGMIKRATSLVDDKPID 1084
SG FT+K N V FD + G++K+ + D K +
Sbjct: 730 LADYVLYKNKVEDSGIFTIKNMINTEEGITLENSFVLLRFD-QTGLMKQMMTKEDGKHHE 788
Query: 1083 LNSHFIHYGARKSKRKFANGNEDNPAGAYLFLPDGEARELKKQSSDWILV-KGEVVQKVF 907
+N F YG + K +GAYLFLPDG A+ + ++ V G + +V
Sbjct: 789 VNVQFSWYGTTIKRDK---------SGAYLFLPDGNAKPYVYTTPPFVRVTHGRIYSEVT 839
Query: 906 ATPNNDLKILQTYTLYQGLPW--IDLDNEVDVRSKENFELALRFSSSVNSGDEFFTDLNG 733
++ ++ Y + QG+ +++ N VD+R N E+A++ SS + S + F+TDLNG
Sbjct: 840 CFFDHVTHRVRLYHI-QGIEGQSVEVSNIVDIRKVYNREIAMKISSDIKSQNRFYTDLNG 898
Query: 732 MQMIKRRRQTKLPTQANFYPMSAGVYIEDDTTRMSIHSAQALGVSSLSSGQIEIMLDRRL 553
Q+ R +KLP QAN YPM+ YI+D R+++ SAQ+LGVSSL+SGQIE+++DRRL
Sbjct: 899 YQIQPRMTLSKLPLQANVYPMTTMAYIQDAKHRLTLLSAQSLGVSSLNSGQIEVIMDRRL 958
Query: 552 SSDDNRGLQQGVRDNKRTVAHFRIVIEPMSSSSGNKKEERVGFHSHVGHLATWSLHYPLV 373
DDNRGL+QG++DNK T FRI++E S+ + ++++ V + S + H+ + +++P++
Sbjct: 959 MQDDNRGLEQGIQDNKITANLFRILLEKRSAVNTEEEKKSVSYPSLLSHITSSLMNHPVI 1018
Query: 372 KMIGDATPK---SISSKNVEQELNCDLHLVTFRTLASPTTYEANERSTAAEKKAAMVMHR 202
M +P ++ L CD+HLV RT+ S +AA+++HR
Sbjct: 1019 PMANKFSPTLELQGEFSPLQSSLPCDIHLVNLRTIQSKV-------GNGHSNEAALILHR 1071
Query: 201 VVPDCRSRLTLPDTSCLATGLEIEPLKLIS--TLKSAKKTSLTNLYE---GNKAEQFRLQ 37
DCR C T +I KL++ ++S +SL+ ++ + L
Sbjct: 1072 KGFDCRFSSKGTGLFCSTTQGKILVQKLLNKFIVESLTPSSLSLMHSPPGTQNISEINLS 1131
Query: 36 PNDISSILV 10
P +IS+ +
Sbjct: 1132 PMEISTFRI 1140
>gi|6678790|ref|NP_032575.1| mannosidase 2, alpha 1 [Mus musculus]
gi|126722|sp|P27046|M2A1_MOUSE Alpha-mannosidase II
(Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase) (MAN
II) (Golgi alpha-mannosidase II) (Mannosidase alpha class
2A member 1) (AMAN II)
gi|110673|pir||A41641 mannosyl-oligosaccharide
1,3-1,6-alpha-mannosidase (EC 3.2.1.114) - mouse
gi|49944|emb|CAA43480.1| mannosyl-oligosaccharide
1,3-1,6-alpha-mannosidase [Mus musculus]
Length = 1150
Score = 713 bits (1841), Expect = 0.0
Identities = 422/1151 (36%), Positives = 654/1151 (56%), Gaps = 46/1151 (3%)
Frame = -1
Query: 3324 QANDLRRKIGNLEHVAEENGRTIDRLEQEVQRAKAEKSVDFDXXXXXXXXXXXXXXXXXV 3145
Q + L+ KI +LE + EN I + V +SV+
Sbjct: 47 QLSILQEKIDHLERLLAENNEIISNIRDSV--INLSESVE-------------------D 85
Query: 3144 APVPVRGNRGEMA-HIHQVKQHIKPTPSMKDVCGIRENVSIAHSDLQMLDLYDTWKFENP 2968
P GN + + H+H + ++ P +D C D+QMLD+YD F+NP
Sbjct: 86 GPRGSPGNASQGSIHLHSPQLALQADP--RD-CLFASQSGSQPRDVQMLDVYDLIPFDNP 142
Query: 2967 DGGVWKQGWKIEYDAEKVKSLPRLEVIVIPHSHCDPGWIMTFEEYYNRQTRNILDGMAKH 2788
DGGVWKQG+ I+Y+A++ P L+V V+PHSH DPGW+ TF +Y+ +T+ I + M
Sbjct: 143 DGGVWKQGFDIKYEADEWDHEP-LQVFVVPHSHNDPGWLKTFNDYFRDKTQYIFNNMVLK 201
Query: 2787 LAEKDEMRFIYAEISFFETWWRDQADEIKKK-VKGYLEAGKFEIVTGGWVMTDEANAHYH 2611
L E +F+++EIS+ WW D D KK+ VK L+ G+ EIVTGGWVM DEA HY
Sbjct: 202 LKEDSSRKFMWSEISYLAKWW-DIIDIPKKEAVKSLLQNGQLEIVTGGWVMPDEATPHYF 260
Query: 2610 SMITELFEGHEWIQNHLGKSAIPQSHWSIDPFGLSPSMPHLLTSANITNAVIQRVHYSVK 2431
++I +L EGH+W++ +LG P+S W+IDPFG SP+M +LL A ++ +IQRVHY++K
Sbjct: 261 ALIDQLIEGHQWLEKNLGVK--PRSGWAIDPFGHSPTMAYLLKRAGFSHMLIQRVHYAIK 318
Query: 2430 RELALKKNLEFYWRQLFGSTGHPDLRSHIMPFYSYDIPHTCGPEPSVCCQFDFRRMPEGG 2251
+ +L K LEF+WRQ + D+ H+MPFYSYDIPHTCGP+P +CCQFDF+R+P G
Sbjct: 319 KHFSLHKTLEFFWRQNWDLGSATDILCHMMPFYSYDIPHTCGPDPKICCQFDFKRLPGGR 378
Query: 2250 KSCDWGIPPQKINDDNVAHRAEMIYDQYRKKSQLFKNNVIFQPLGDDFRYDIDFEWNSQY 2071
C WG+PP+ I+ NV RA+M+ DQYRKKS+LF+ V+ PLGDDFR+ EW+ Q
Sbjct: 379 YGCPWGVPPEAISPGNVQSRAQMLLDQYRKKSKLFRTKVLLAPLGDDFRFSEYTEWDLQC 438
Query: 2070 ENYKKLFEYMNSKSEWNVHAQFGTLSDYFKKLDTAISA----SGEQLPTFSGDFFTYADR 1903
NY++LF YMNS+ V QFGTLSDYF L+ A++A S P SGDFFTYADR
Sbjct: 439 RNYEQLFSYMNSQPHLKVKIQFGTLSDYFDALEKAVAAEKKSSQSVFPALSGDFFTYADR 498
Query: 1902 DDHYWSGYFTSRPFYKQLDRVLQHYLRSAEIAFTLA-----NIEEEGMVEAKIFEKLVTA 1738
DDHYWSGYFTSRPFYK++DR+++ +R+AEI + LA + + + + L A
Sbjct: 499 DDHYWSGYFTSRPFYKRMDRIMESRIRAAEILYQLALKQAQKYKINKFLSSPHYTTLTEA 558
Query: 1737 RRALSLFQHHDGVTGTAKDHVVLDYGQKMIDALNACEDILSEALVVLLGID--------S 1582
RR L LFQHHD +TGTAKD VV+DYG ++ +LN+ E I+ ++ +L+ D S
Sbjct: 559 RRNLGLFQHHDAITGTAKDWVVVDYGTRLFQSLNSLEKIIGDSAFLLILKDKKLYQSDPS 618
Query: 1581 TNKMQMDEHRVNENLLPEKRVYKIG----QNVVLFNTLSRNRNEPICIQVDSLDAGVEAD 1414
++MD + +++ LP+K + ++ + +V++N + R+ + I+V+S V +D
Sbjct: 619 KAFLEMDTKQSSQDSLPQKIIIQLSAQEPRYLVVYNPFEQERHSVVSIRVNSATGKVLSD 678
Query: 1413 --PPIKKQQVSPVIAYDEEKKTLVVKNGIFELCFMLSLGPMESVSFRLVKNTTTSK---V 1249
P++ Q V A + +T + +E+ F+ + P+ F+++++ ++S
Sbjct: 679 SGKPVEVQ----VSAVWNDMRT--ISQAAYEVSFLAHIPPLGLKVFKILESQSSSSHLAD 732
Query: 1248 EIITNN--AAXXXXXXXXXXXXSGD-FTVKNDKVEAEFDGENGMIKRATSLVDDKPIDLN 1078
++ NN A +GD T++N + FD +G++++ D + +L
Sbjct: 733 YVLYNNDGLAENGIFHVKNMVDAGDAITIENPFLAIWFD-RSGLMEKVRRKEDSRQHELK 791
Query: 1077 SHFIHYGARKSKRKFANGNEDNPAGAYLFLPDGEARELKKQSSDWILV-KGEVVQKVFAT 901
F+ YG N+ + +GAYLFLPDG+ + ++ V +G + V
Sbjct: 792 VQFLWYGTT---------NKRDKSGAYLFLPDGQGQPYVSLRPPFVRVTRGRIYSDVTCF 842
Query: 900 PNNDLKILQTYTLYQGLPW--IDLDNEVDVRSKENFELALRFSSSVNSGDEFFTDLNGMQ 727
+ ++ Y + QG+ +++ N V++R+ N E+ +R SS +N+ + ++TDLNG Q
Sbjct: 843 LEHVTHKVRLYNI-QGIEGQSMEVSNIVNIRNVHNREIVMRISSKINNQNRYYTDLNGYQ 901
Query: 726 MIKRRRQTKLPTQANFYPMSAGVYIEDDTTRMSIHSAQALGVSSLSSGQIEIMLDRRLSS 547
+ RR +KLP QAN YPM YI+D R+++ SAQ+LG SS++SGQIE+ +DRRL
Sbjct: 902 IQPRRTMSKLPLQANVYPMCTMAYIQDAEHRLTLLSAQSLGASSMASGQIEVFMDRRLMQ 961
Query: 546 DDNRGLQQGVRDNKRTVAHFRIVIEPMSS-SSGNKKEERVGFHSHVGHLATWSLHYPLVK 370
DDNRGL QGV DNK T FRI++E S+ + +K+ V + S + H+ + L++P +
Sbjct: 962 DDNRGLGQGVHDNKITANLFRILLEKRSAVNMEEEKKSPVSYPSLLSHMTSSFLNHPFLP 1021
Query: 369 MIGDATPKSISSK------NVEQELNCDLHLVTFRTLASPTTYEANERSTAAEKKAAMVM 208
M+ S + + ++ L CD+HLV RT+ S + +AA+++
Sbjct: 1022 MVLSGQLPSPAFELLSEFPLLQSSLPCDIHLVNLRTIQS-------KMGKGYSDEAALIL 1074
Query: 207 HRVVPDCRSRLTLPDTSCLATGLEIEPLKLIS--TLKSAKKTSLTNLY---EGNKAEQFR 43
HR DC+ C T ++ LKL + ++S +SL+ ++ + +
Sbjct: 1075 HRKGFDCQFSSRGIGLPCSTTQGKMSVLKLFNKFAVESLVPSSLSLMHSPPDAQNMSEVS 1134
Query: 42 LQPNDISSILV 10
L P +IS+ +
Sbjct: 1135 LSPMEISTFRI 1145
>gi|517481|emb|CAA54732.1| putative golgi alpha-mannosidase II
[Drosophila melanogaster]
Length = 1108
Score = 705 bits (1819), Expect = 0.0
Identities = 408/1060 (38%), Positives = 612/1060 (57%), Gaps = 39/1060 (3%)
Frame = -1
Query: 3426 KRNFYIILCLGVFLT-VSLYLYNGIETGAEALTKRQANDLRRKIGNLEHVAEENGRTIDR 3250
+R F +++C G L +SLY+ A K ++ K+ LE+ +E+G +
Sbjct: 5 RRRFALVICSGCLLVFLSLYIILNFAAPAATQIKPNYENIENKLHELENGLQEHGEEMRN 64
Query: 3249 LEQEVQRAKAEKSVDFDXXXXXXXXXXXXXXXXXVAPVPVRGNRGEMAHIHQVKQHIKPT 3070
L RA+ K+ + D P+R +K P
Sbjct: 65 L-----RARLAKTSNRDD--------------------PIRP---------PLKVARSPR 90
Query: 3069 PSM-KDVCGIRENVSIAHSDLQMLDLYDTWKFENPDGGVWKQGWKIEYDAEKVKSLPRLE 2893
P +DV NV D+QML+LYD F++ DGGVWKQGW I+YD K + +L+
Sbjct: 91 PGQCQDVVQDVPNV-----DVQMLELYDRMSFKDIDGGVWKQGWNIKYDPLKYNAHHKLK 145
Query: 2892 VIVIPHSHCDPGWIMTFEEYYNRQTRNILDGMAKHLAEKDEMRFIYAEISFFETWWRDQA 2713
V V+PHSH DPGWI TFEEYY T++IL +HL + EM+FI+AEIS+F ++ D
Sbjct: 146 VFVVPHSHNDPGWIQTFEEYYQHDTKHILSNALRHLHDNPEMKFIWAEISYFARFYHDLG 205
Query: 2712 DEIKKKVKGYLEAGKFEIVTGGWVMTDEANAHYHSMITELFEGHEWIQNHLGKSAIPQSH 2533
+ K ++K ++ G+ E VTGGWVM DEAN+H+ +++ +L EG W++ + + P +
Sbjct: 206 ENKKLQMKSIVKNGQLEFVTGGWVMPDEANSHWRNVLLQLTEGQTWLKQFM--NVTPTAS 263
Query: 2532 WSIDPFGLSPSMPHLLTSANITNAVIQRVHYSVKRELALKKNLEFYWRQLFGSTGHPDLR 2353
W+IDPFG SP+MP++L + N +IQR HYSVK+ELA ++ LEF WRQ++ + G L
Sbjct: 264 WAIDPFGHSPTMPYILQKSGFKNMLIQRTHYSVKKELAQQRQLEFLWRQIWDNKGDTALF 323
Query: 2352 SHIMPFYSYDIPHTCGPEPSVCCQFDFRRMPEGGKSCDWGIPPQKINDDNVAHRAEMIYD 2173
+H+MPFYSYDIPHTCGP+P VCCQFDF+RM G SC W +PP+ I+D NVA R++++ D
Sbjct: 324 THMMPFYSYDIPHTCGPDPKVCCQFDFKRMGSFGLSCPWKVPPRTISDQNVAARSDLLVD 383
Query: 2172 QYRKKSQLFKNNVIFQPLGDDFRYDIDFEWNSQYENYKKLFEYMNSKSEWNVHAQFGTLS 1993
Q++KK++L++ NV+ PLGDDFR+ + EW+ Q NY++LFE++NS++ +NV AQFGTL
Sbjct: 384 QWKKKAELYRTNVLLIPLGDDFRFKQNTEWDVQRVNYERLFEHINSQAHFNVQAQFGTLQ 443
Query: 1992 DYFKKLDTAISASGEQLPTFSGDFFTYADRDDHYWSGYFTSRPFYKQLDRVLQHYLRSAE 1813
+YF + A A + PT SGDFFTYADR D+YWSGY+TSRP++K++DRVL HY+R+AE
Sbjct: 444 EYFDAVHQAERAGQAEFPTLSGDFFTYADRSDNYWSGYYTSRPYHKRMDRVLMHYVRAAE 503
Query: 1812 IAFTLANIEEEGMVEAKIFEKLVTARRALSLFQHHDGVTGTAKDHVVLDYGQKMIDALNA 1633
+ A +GM A+I E+L ARR LSLFQHHDG+TGTAK HVV+DY Q+M +AL A
Sbjct: 504 M--LSAWHSWDGM--ARIEERLEQARRELSLFQHHDGITGTAKTHVVVDYEQRMQEALKA 559
Query: 1632 CEDILSEALVVLLGIDST-------NKMQMDEHR--------------VNENLLPEKRVY 1516
C+ ++ +++ LL S + +D+ R + E++LP K
Sbjct: 560 CQMVMQQSVYRLLTKPSIYSPDFSFSYFTLDDSRWPGSGVEDSRTTIILGEDILPSK--- 616
Query: 1515 KIGQNVVLFNTLSRNRNEPICIQVDSLDAGVE--ADPPIKKQQVSPVIAYDEEKKTLVV- 1345
+VV+ NTL R + + V S V A+ P+ + QVSPV ++ + T +
Sbjct: 617 ----HVVMHNTLPHWREQLVDFYVSSPFVSVTDLANNPV-EAQVSPVWSWHHDTLTKTIH 671
Query: 1344 ---KNGIFELCFMLSLGPMESVSFRLV------KNTTTSKVEIITNNAAXXXXXXXXXXX 1192
+ + F + PM ++ L ++T+ + ++ N
Sbjct: 672 PQGSTTKYRIIFKARVPPMGLATYVLTISDSKPEHTSYASNLLLRKNPTSLPLGQYPEDV 731
Query: 1191 XSGD---FTVKNDKVEAEFDGENGMIKRATSLVDDKPIDLNSHFIHYGARKSKRKFANGN 1021
GD +++ E G++K D + ++ F+ YG R +
Sbjct: 732 KFGDPREISLRVGNGPTLAFSEQGLLKSIQLTQDSPHVPVHFKFLKYGVR---------S 782
Query: 1020 EDNPAGAYLFLPDGEARELKKQSSDWILVKGEVVQKV-FATPNNDLKILQTYTLYQGLPW 844
+ +GAYLFLP+G A ++ ++ KG++ V P+ ++ + G P
Sbjct: 783 HGDRSGAYLFLPNGPASPVELGQPVVLVTKGKLESSVSVGLPS----VVHQTIMRGGAP- 837
Query: 843 IDLDNEVDVRSKENFELALRFSSSVNSGDEFFTDLNGMQMIKRRRQTKLPTQANFYPMSA 664
++ N VD+ S +N E+ +R + ++SGD F+TDLNG+Q IKRRR KLP QAN+YP+ +
Sbjct: 838 -EIRNLVDIGSLDNTEIVMRLETHIDSGDIFYTDLNGLQFIKRRRLDKLPLQANYYPIPS 896
Query: 663 GVYIEDDTTRMSIHSAQALGVSSLSSGQIEIMLDRRLSSDDNRGLQQGVRDNKRTVAHFR 484
G++IED TR+++ + Q LG SSL+SG++EIM DRRL+SDD RGL QGV DNK + +R
Sbjct: 897 GMFIEDANTRLTLLTGQPLGGSSLASGELEIMQDRRLASDDERGLGQGVLDNKPVLHIYR 956
Query: 483 IVIEPMSSSSGNKKEERVGFHSHVGHLATWSLHYPLVKMI 364
+V+E +++ K G+ + H A+ SL PL K I
Sbjct: 957 LVLEKVNNCVRPSKLHPAGYLTSAAHKASQSLLDPLDKFI 996
>gi|47219822|emb|CAG03449.1| unnamed protein product [Tetraodon
nigroviridis]
Length = 1152
Score = 705 bits (1819), Expect = 0.0
Identities = 378/928 (40%), Positives = 568/928 (60%), Gaps = 40/928 (4%)
Frame = -1
Query: 3030 SIAHSDLQMLDLYDTWKFENPDGGVWKQGWKIEYDAEKVKSLPRLEVIVIPHSHCDPGWI 2851
S +D+QMLD+Y KF+NPDGGVWKQG+ I Y+ ++ + P L+V V+PHSH DPGW+
Sbjct: 123 SHGQADVQMLDVYSLLKFDNPDGGVWKQGFDITYEPDEWDTEP-LQVFVVPHSHNDPGWV 181
Query: 2850 MTFEEYYNRQTRNILDGMAKHLAEKDEMRFIYAEISFFETWWRDQADEIKKKV-KGYLEA 2674
TF++Y+ QT++IL+ M LAE +FI++EIS+F WW + AD K++V + +
Sbjct: 182 KTFDKYFMEQTQHILNNMVVKLAEDPRRKFIWSEISYFAKWW-EAADAYKQEVMRKLILG 240
Query: 2673 GKFEIVTGGWVMTDEANAHYHSMITELFEGHEWIQNHLGKSAIPQSHWSIDPFGLSPSMP 2494
G+ EIVTGGWVMTDEAN HY +M+ +L EGH+W++ +LG + P+S W++DPFG S +MP
Sbjct: 241 GQLEIVTGGWVMTDEANVHYFAMLDQLIEGHQWLERNLGVT--PRSAWAVDPFGHSATMP 298
Query: 2493 HLLTSANITNAVIQRVHYSVKRELALKKNLEFYWRQLFGSTGHPDLRSHIMPFYSYDIPH 2314
++L +N+T+ +IQRVHYS+K+ A ++LEF WRQ + D+ H+MPFYSYD+PH
Sbjct: 299 YMLKRSNLTSMLIQRVHYSIKKHFASTRSLEFMWRQAWDKGSSTDIFCHMMPFYSYDVPH 358
Query: 2313 TCGPEPSVCCQFDFRRMPEGGKSCDWGIPPQKINDDNVAHRAEMIYDQYRKKSQLFKNNV 2134
TCGP+P +CCQFDF+R+P G +C W +PP+ + D NVA RA ++ DQYRKKS+L+++NV
Sbjct: 359 TCGPDPKICCQFDFKRLPGGRINCPWKVPPKTVVDANVAERANLLLDQYRKKSKLYRSNV 418
Query: 2133 IFQPLGDDFRYDIDFEWNSQYENYKKLFEYMNSKSEWNVHAQFGTLSDYF----KKLDTA 1966
+ PLGDDFRYD EW+ QY NY+KLF++MNS E +V AQFGTLSDYF K A
Sbjct: 419 LLVPLGDDFRYDKALEWDQQYTNYQKLFDHMNSHPEMHVQAQFGTLSDYFNAVYKAHGVA 478
Query: 1965 ISASGEQLPTFSGDFFTYADRDDHYWSGYFTSRPFYKQLDRVLQHYLRSAEIAFTLA--- 1795
+ P SGDFF YADR+DHYW+GYFTSRPFYK +DRV++ +LR AEI ++LA
Sbjct: 479 QGSRPADYPVLSGDFFAYADREDHYWTGYFTSRPFYKSMDRVIESHLRGAEILYSLAVAN 538
Query: 1794 --NIEEEGMVEAKIFEKLVTARRALSLFQHHDGVTGTAKDHVVLDYGQKMIDALNACEDI 1621
+ EG + LV ARR++ LFQHHD +TGTAK++VV+DYG K++ +L + +
Sbjct: 539 ARHAGMEGRYPVSDYGLLVDARRSVGLFQHHDAITGTAKENVVIDYGNKLLRSLIGLKRV 598
Query: 1620 LSEALVVLLGIDSTNK-----------MQMDEHRVNENLLPEKRVYKIG----QNVVLFN 1486
+ A L+ NK ++ D+ R ++ LP++ + ++ + +V+FN
Sbjct: 599 IINAAHFLV---MKNKEFYRFYQTEPFLETDDRRATQDSLPQRTLIELDPAGPRYLVVFN 655
Query: 1485 TLSRNRNEPICIQVDSLDAGVEADPPIKKQQVSPVIAYDEEKKTLVVKNGIFELCFMLSL 1306
+ + R + + V+++ V + Q PV + + +FE FM+ L
Sbjct: 656 PIEQERLCTVTVLVNTVKVRVLTE----DGQTLPVQLSAQWSSASQMSAEVFEATFMVRL 711
Query: 1305 GPMESVSFRLVKN-------TTTSKVEIITNNAAXXXXXXXXXXXXSGD---FTVKNDKV 1156
+ F L ++ + + + + + A D F V + +
Sbjct: 712 PALGLAVFHLYESPDSPMTLRSDTLLRLSSRGVAARAVDPLPVRSQPSDAHTFYVSSQSL 771
Query: 1155 EAEFDGENGMIKRATSLVDDKPIDLNSHFIHYGARKSKRKFANGNEDNPAGAYLFLPDGE 976
F G G+++ D + + + F+ YG R SK K +GAYLFLPDG+
Sbjct: 772 TLGFSGTTGLLESIKRKDDGQEVKVQMQFMMYGTRPSKDK---------SGAYLFLPDGK 822
Query: 975 AREL-KKQSSDWILVKGEVVQKVFATPNNDLKILQTYTLYQGLPWIDLD--NEVDVRSKE 805
A+ +K+ S +V+G + +V A + + ++ Y + G+ LD VD+R +
Sbjct: 823 AKPYSQKEPSVVRVVEGPLFSEVVAHYQHFQQAIRIYNV-PGVDGFSLDVTTTVDIRDQN 881
Query: 804 NFELALRFSSSVNSGDEFFTDLNGMQMIKRRRQTKLPTQANFYPMSAGVYIEDDTTRMSI 625
N EL++R +++ SGD F+TD N Q+ R KLP QANFYPM + YI+D R+++
Sbjct: 882 NKELSMRLVTNIQSGDVFYTDHNAFQIQPCRHFMKLPLQANFYPMPSQAYIQDSNYRLTL 941
Query: 624 HSAQALGVSSLSSGQIEIMLDRRLSSDDNRGLQQGVRDNKRTVAHFRIVIEPMSSSSGNK 445
H+AQALGVSSL +GQ+E++LDRRL DDNRGL QG++DNK+T+ FR+++E S GNK
Sbjct: 942 HTAQALGVSSLETGQLEVILDRRLMQDDNRGLGQGLKDNKKTINRFRLLLE--RRSLGNK 999
Query: 444 KEERV--GFHSHVGHLATWSLHYPLVKM 367
+ F S + H+ + L++ ++ +
Sbjct: 1000 MVDATSSSFPSILSHMTSSFLNHEVLAL 1027
>gi|24645354|ref|NP_524291.2| CG18802-PA [Drosophila melanogaster]
gi|32130434|sp|Q24451|MAN2_DROME Alpha-mannosidase II
(Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase) (MAN
II) (Golgi alpha-mannosidase II) (AMAN II)
gi|7299177|gb|AAF54375.1| CG18802-PA [Drosophila melanogaster]
gi|21428798|gb|AAM50118.1| GH03876p [Drosophila melanogaster]
Length = 1108
Score = 702 bits (1811), Expect = 0.0
Identities = 406/1060 (38%), Positives = 612/1060 (57%), Gaps = 39/1060 (3%)
Frame = -1
Query: 3426 KRNFYIILCLGVFLT-VSLYLYNGIETGAEALTKRQANDLRRKIGNLEHVAEENGRTIDR 3250
+R F +++C G L +SLY+ A K ++ K+ LE+ +E+G +
Sbjct: 5 RRRFALVICSGCLLVFLSLYIILNFAAPAATQIKPNYENIENKLHELENGLQEHGEEMRN 64
Query: 3249 LEQEVQRAKAEKSVDFDXXXXXXXXXXXXXXXXXVAPVPVRGNRGEMAHIHQVKQHIKPT 3070
L RA+ ++ + D P+R +K P
Sbjct: 65 L-----RARLAETSNRDD--------------------PIRP---------PLKVARSPR 90
Query: 3069 PSM-KDVCGIRENVSIAHSDLQMLDLYDTWKFENPDGGVWKQGWKIEYDAEKVKSLPRLE 2893
P +DV NV D+QML+LYD F++ DGGVWKQGW I+YD K + +L+
Sbjct: 91 PGQCQDVVQDVPNV-----DVQMLELYDRMSFKDIDGGVWKQGWNIKYDPLKYNAHHKLK 145
Query: 2892 VIVIPHSHCDPGWIMTFEEYYNRQTRNILDGMAKHLAEKDEMRFIYAEISFFETWWRDQA 2713
V V+PHSH DPGWI TFEEYY T++IL +HL + EM+FI+AEIS+F ++ D
Sbjct: 146 VFVVPHSHNDPGWIQTFEEYYQHDTKHILSNALRHLHDNPEMKFIWAEISYFARFYHDLG 205
Query: 2712 DEIKKKVKGYLEAGKFEIVTGGWVMTDEANAHYHSMITELFEGHEWIQNHLGKSAIPQSH 2533
+ K ++K ++ G+ E VTGGWVM DEAN+H+ +++ +L EG W++ + + P +
Sbjct: 206 ENKKLQMKSIVKNGQLEFVTGGWVMPDEANSHWRNVLLQLTEGQTWLKQFM--NVTPTAS 263
Query: 2532 WSIDPFGLSPSMPHLLTSANITNAVIQRVHYSVKRELALKKNLEFYWRQLFGSTGHPDLR 2353
W+IDPFG SP+MP++L + N +IQR HYSVK+ELA ++ LEF WRQ++ + G L
Sbjct: 264 WAIDPFGHSPTMPYILQKSGFKNMLIQRTHYSVKKELAQQRQLEFLWRQIWDNKGDTALF 323
Query: 2352 SHIMPFYSYDIPHTCGPEPSVCCQFDFRRMPEGGKSCDWGIPPQKINDDNVAHRAEMIYD 2173
+H+MPFYSYDIPHTCGP+P VCCQFDF+RM G SC W +PP+ I+D NVA R++++ D
Sbjct: 324 THMMPFYSYDIPHTCGPDPKVCCQFDFKRMGSFGLSCPWKVPPRTISDQNVAARSDLLVD 383
Query: 2172 QYRKKSQLFKNNVIFQPLGDDFRYDIDFEWNSQYENYKKLFEYMNSKSEWNVHAQFGTLS 1993
Q++KK++L++ NV+ PLGDDFR+ + EW+ Q NY++LFE++NS++ +NV AQFGTL
Sbjct: 384 QWKKKAELYRTNVLLIPLGDDFRFKQNTEWDVQRVNYERLFEHINSQAHFNVQAQFGTLQ 443
Query: 1992 DYFKKLDTAISASGEQLPTFSGDFFTYADRDDHYWSGYFTSRPFYKQLDRVLQHYLRSAE 1813
+YF + A A + PT SGDFFTYADR D+YWSGY+TSRP++K++DRVL HY+R+AE
Sbjct: 444 EYFDAVHQAERAGQAEFPTLSGDFFTYADRSDNYWSGYYTSRPYHKRMDRVLMHYVRAAE 503
Query: 1812 IAFTLANIEEEGMVEAKIFEKLVTARRALSLFQHHDGVTGTAKDHVVLDYGQKMIDALNA 1633
+ A +GM A+I E+L ARR LSLFQHHDG+TGTAK HVV+DY Q+M +AL A
Sbjct: 504 M--LSAWHSWDGM--ARIEERLEQARRELSLFQHHDGITGTAKTHVVVDYEQRMQEALKA 559
Query: 1632 CEDILSEALVVLLGIDST-------NKMQMDEHR--------------VNENLLPEKRVY 1516
C+ ++ +++ LL S + +D+ R + E++LP K
Sbjct: 560 CQMVMQQSVYRLLTKPSIYSPDFSFSYFTLDDSRWPGSGVEDSRTTIILGEDILPSK--- 616
Query: 1515 KIGQNVVLFNTLSRNRNEPICIQVDSLDAGVE--ADPPIKKQQVSPVIAYDEEKKTLVV- 1345
+VV+ NTL R + + V S V A+ P+ + QVSPV ++ + T +
Sbjct: 617 ----HVVMHNTLPHWREQLVDFYVSSPFVSVTDLANNPV-EAQVSPVWSWHHDTLTKTIH 671
Query: 1344 ---KNGIFELCFMLSLGPMESVSFRLV------KNTTTSKVEIITNNAAXXXXXXXXXXX 1192
+ + F + PM ++ L ++T+ + ++ N
Sbjct: 672 PQGSTTKYRIIFKARVPPMGLATYVLTISDSKPEHTSYASNLLLRKNPTSLPLGQYPEDV 731
Query: 1191 XSGD---FTVKNDKVEAEFDGENGMIKRATSLVDDKPIDLNSHFIHYGARKSKRKFANGN 1021
GD +++ E G++K D + ++ F+ YG R +
Sbjct: 732 KFGDPREISLRVGNGPTLAFSEQGLLKSIQLTQDSPHVPVHFKFLKYGVR---------S 782
Query: 1020 EDNPAGAYLFLPDGEARELKKQSSDWILVKGEVVQKV-FATPNNDLKILQTYTLYQGLPW 844
+ +GAYLFLP+G A ++ ++ KG++ V P+ ++ + G P
Sbjct: 783 HGDRSGAYLFLPNGPASPVELGQPVVLVTKGKLESSVSVGLPS----VVHQTIMRGGAP- 837
Query: 843 IDLDNEVDVRSKENFELALRFSSSVNSGDEFFTDLNGMQMIKRRRQTKLPTQANFYPMSA 664
++ N VD+ S +N E+ +R + ++SGD F+TDLNG+Q IKRRR KLP QAN+YP+ +
Sbjct: 838 -EIRNLVDIGSLDNTEIVMRLETHIDSGDIFYTDLNGLQFIKRRRLDKLPLQANYYPIPS 896
Query: 663 GVYIEDDTTRMSIHSAQALGVSSLSSGQIEIMLDRRLSSDDNRGLQQGVRDNKRTVAHFR 484
G++IED TR+++ + Q LG SSL+SG++EIM DRRL+SDD RGL QGV DNK + +R
Sbjct: 897 GMFIEDANTRLTLLTGQPLGGSSLASGELEIMQDRRLASDDERGLGQGVLDNKPVLHIYR 956
Query: 483 IVIEPMSSSSGNKKEERVGFHSHVGHLATWSLHYPLVKMI 364
+V+E +++ + G+ + H A+ SL PL K I
Sbjct: 957 LVLEKVNNCVRPSELHPAGYLTSAAHKASQSLLDPLDKFI 996
>gi|4220556|emb|CAA10755.1| alpha-mannosidase II [Drosophila
melanogaster]
Length = 1108
Score = 701 bits (1810), Expect = 0.0
Identities = 405/1060 (38%), Positives = 613/1060 (57%), Gaps = 39/1060 (3%)
Frame = -1
Query: 3426 KRNFYIILCLGVFLT-VSLYLYNGIETGAEALTKRQANDLRRKIGNLEHVAEENGRTIDR 3250
+R F +++C G L +SLY+ A K ++ K+ LE+ +E+G +
Sbjct: 5 RRRFALVICSGCLLVFLSLYIILNFAAPAATQIKPNYENIENKLHELENGLQEHGEEMRN 64
Query: 3249 LEQEVQRAKAEKSVDFDXXXXXXXXXXXXXXXXXVAPVPVRGNRGEMAHIHQVKQHIKPT 3070
L RA+ ++ + D P+R +K P
Sbjct: 65 L-----RARLAETSNRDD--------------------PIRP---------PLKVARSPR 90
Query: 3069 PSM-KDVCGIRENVSIAHSDLQMLDLYDTWKFENPDGGVWKQGWKIEYDAEKVKSLPRLE 2893
P +DV NV D+QML+LYD F++ DGGVWKQGW I+YD K + +L+
Sbjct: 91 PGQCQDVVQDVPNV-----DVQMLELYDRMSFKDIDGGVWKQGWNIKYDPLKYNAHHKLK 145
Query: 2892 VIVIPHSHCDPGWIMTFEEYYNRQTRNILDGMAKHLAEKDEMRFIYAEISFFETWWRDQA 2713
V V+PHSH DPGWI TFEEYY T++IL +HL + EM+FI+AEIS+F ++ D
Sbjct: 146 VFVVPHSHNDPGWIQTFEEYYQHDTKHILSNALRHLHDNPEMKFIWAEISYFARFYHDLG 205
Query: 2712 DEIKKKVKGYLEAGKFEIVTGGWVMTDEANAHYHSMITELFEGHEWIQNHLGKSAIPQSH 2533
+ K ++K ++ G+ E VTGGWVM DEAN+H+ +++ +L EG W++ + + P +
Sbjct: 206 ENKKLQMKSIVKNGQLEFVTGGWVMPDEANSHWRNVLLQLTEGQTWLKQFM--NVTPTAS 263
Query: 2532 WSIDPFGLSPSMPHLLTSANITNAVIQRVHYSVKRELALKKNLEFYWRQLFGSTGHPDLR 2353
W+IDPFG SP+MP++L + N +IQR HYSVK+ELA ++++EF WRQ++ + G L
Sbjct: 264 WAIDPFGHSPTMPYILQKSGFKNMLIQRTHYSVKKELAQQRHVEFLWRQIWDNKGDTALF 323
Query: 2352 SHIMPFYSYDIPHTCGPEPSVCCQFDFRRMPEGGKSCDWGIPPQKINDDNVAHRAEMIYD 2173
+H+MPFYSYDIPHTCGP+P VCCQFDF+RM G SC W +PP+ I+D NVA R++++ D
Sbjct: 324 THMMPFYSYDIPHTCGPDPKVCCQFDFKRMGSFGLSCPWKVPPRTISDQNVAARSDLLVD 383
Query: 2172 QYRKKSQLFKNNVIFQPLGDDFRYDIDFEWNSQYENYKKLFEYMNSKSEWNVHAQFGTLS 1993
Q++KK++L++ NV+ PLGDDFR+ + EW+ Q NY++LFE++NS++ +NV AQFGTL
Sbjct: 384 QWKKKAELYRTNVVLIPLGDDFRFKQNTEWDVQRVNYERLFEHINSQAHFNVQAQFGTLQ 443
Query: 1992 DYFKKLDTAISASGEQLPTFSGDFFTYADRDDHYWSGYFTSRPFYKQLDRVLQHYLRSAE 1813
+YF + A A + PT SGDFFTYADR D+YWSGY+TSRP++K++DRVL HY+R+AE
Sbjct: 444 EYFDAVHQAERAGQAEFPTLSGDFFTYADRSDNYWSGYYTSRPYHKRMDRVLMHYVRAAE 503
Query: 1812 IAFTLANIEEEGMVEAKIFEKLVTARRALSLFQHHDGVTGTAKDHVVLDYGQKMIDALNA 1633
+ A +GM A+I E+L ARR LSLFQHHDG+TGTAK HVV+DY Q+M +AL A
Sbjct: 504 M--LSAWHSWDGM--ARIEERLEQARRELSLFQHHDGITGTAKTHVVVDYEQRMQEALKA 559
Query: 1632 CEDILSEALVVLLGIDST-------NKMQMDEHR--------------VNENLLPEKRVY 1516
C+ ++ +++ LL S + +D+ R + E++LP K
Sbjct: 560 CQMVMQQSVYRLLTKPSIYSPDFSFSYFTLDDSRWPGSGVEDSRTTIILGEDILPSK--- 616
Query: 1515 KIGQNVVLFNTLSRNRNEPICIQVDSLDAGVE--ADPPIKKQQVSPVIAYDEEKKTLVV- 1345
+VV+ NTL R + + V S V A+ P+ + QVSPV ++ + T +
Sbjct: 617 ----HVVMHNTLPHWREQLVDFYVSSPFVSVTDLANNPV-EAQVSPVWSWHHDTLTKTIH 671
Query: 1344 ---KNGIFELCFMLSLGPMESVSFRLV------KNTTTSKVEIITNNAAXXXXXXXXXXX 1192
+ + F + PM ++ L ++T+ + ++ N
Sbjct: 672 PQGSTTKYRIIFKARVPPMGLATYVLTISDSKPEHTSYASNLLLRKNPTSLPLGQYPEDV 731
Query: 1191 XSGD---FTVKNDKVEAEFDGENGMIKRATSLVDDKPIDLNSHFIHYGARKSKRKFANGN 1021
GD +++ E G++K D + ++ F+ YG R +
Sbjct: 732 KFGDPREISLRVGNGPTLAFSEQGLLKSIQLTQDSPHVPVHFKFLKYGVR---------S 782
Query: 1020 EDNPAGAYLFLPDGEARELKKQSSDWILVKGEVVQKV-FATPNNDLKILQTYTLYQGLPW 844
+ +GAYLFLP+G A ++ ++ KG++ V P+ ++ + G P
Sbjct: 783 HGDRSGAYLFLPNGPASPVELGQPVVLVTKGKLESSVSVGLPS----VVHQTIMRGGAP- 837
Query: 843 IDLDNEVDVRSKENFELALRFSSSVNSGDEFFTDLNGMQMIKRRRQTKLPTQANFYPMSA 664
++ N VD+ S +N E+ +R + ++SGD F+TDLNG+Q IKRRR KLP QAN+YP+ +
Sbjct: 838 -EIRNLVDIGSLDNTEIVMRLETHIDSGDIFYTDLNGLQFIKRRRLDKLPLQANYYPIPS 896
Query: 663 GVYIEDDTTRMSIHSAQALGVSSLSSGQIEIMLDRRLSSDDNRGLQQGVRDNKRTVAHFR 484
G++IED TR+++ + Q LG SSL+SG++EIM DRRL+SDD RGL QGV DNK + +R
Sbjct: 897 GMFIEDANTRLTLLTGQPLGGSSLASGELEIMQDRRLASDDERGLGQGVLDNKPVLHIYR 956
Query: 483 IVIEPMSSSSGNKKEERVGFHSHVGHLATWSLHYPLVKMI 364
+V+E +++ + G+ + H A+ SL PL K I
Sbjct: 957 LVLEKVNNCVRPSELHPAGYLTSAAHKASQSLLDPLDKFI 996
>gi|18655827|pdb|1HXK|A Chain A, Golgi Alpha-Mannosidase Ii In Complex
With Deoxymannojirimicin
gi|18655949|pdb|1HWW|A Chain A, Golgi Alpha-Mannosidase Ii In Complex
With Swainsonine
Length = 1015
Score = 697 bits (1800), Expect = 0.0
Identities = 379/925 (40%), Positives = 566/925 (60%), Gaps = 37/925 (4%)
Frame = -1
Query: 3027 IAHSDLQMLDLYDTWKFENPDGGVWKQGWKIEYDAEKVKSLPRLEVIVIPHSHCDPGWIM 2848
+ + D+QML+LYD F++ DGGVWKQGW I+YD K + +L+V V+PHSH DPGWI
Sbjct: 8 VPNVDVQMLELYDRMSFKDIDGGVWKQGWNIKYDPLKYNAHHKLKVFVVPHSHNDPGWIQ 67
Query: 2847 TFEEYYNRQTRNILDGMAKHLAEKDEMRFIYAEISFFETWWRDQADEIKKKVKGYLEAGK 2668
TFEEYY T++IL +HL + EM+FI+AEIS+F ++ D + K ++K ++ G+
Sbjct: 68 TFEEYYQHDTKHILSNALRHLHDNPEMKFIWAEISYFARFYHDLGENKKLQMKSIVKNGQ 127
Query: 2667 FEIVTGGWVMTDEANAHYHSMITELFEGHEWIQNHLGKSAIPQSHWSIDPFGLSPSMPHL 2488
E VTGGWVM DEAN+H+ +++ +L EG W++ + + P + W+IDPFG SP+MP++
Sbjct: 128 LEFVTGGWVMPDEANSHWRNVLLQLTEGQTWLKQFM--NVTPTASWAIDPFGHSPTMPYI 185
Query: 2487 LTSANITNAVIQRVHYSVKRELALKKNLEFYWRQLFGSTGHPDLRSHIMPFYSYDIPHTC 2308
L + N +IQR HYSVK+ELA ++ LEF WRQ++ + G L +H+MPFYSYDIPHTC
Sbjct: 186 LQKSGFKNMLIQRTHYSVKKELAQQRQLEFLWRQIWDNKGDTALFTHMMPFYSYDIPHTC 245
Query: 2307 GPEPSVCCQFDFRRMPEGGKSCDWGIPPQKINDDNVAHRAEMIYDQYRKKSQLFKNNVIF 2128
GP+P VCCQFDF+RM G SC W +PP+ I+D NVA R++++ DQ++KK++L++ NV+
Sbjct: 246 GPDPKVCCQFDFKRMGSFGLSCPWKVPPRTISDQNVAARSDLLVDQWKKKAELYRTNVLL 305
Query: 2127 QPLGDDFRYDIDFEWNSQYENYKKLFEYMNSKSEWNVHAQFGTLSDYFKKLDTAISASGE 1948
PLGDDFR+ + EW+ Q NY++LFE++NS++ +NV AQFGTL +YF + A A
Sbjct: 306 IPLGDDFRFKQNTEWDVQRVNYERLFEHINSQAHFNVQAQFGTLQEYFDAVHQAERAGQA 365
Query: 1947 QLPTFSGDFFTYADRDDHYWSGYFTSRPFYKQLDRVLQHYLRSAEIAFTLANIEEEGMVE 1768
+ PT SGDFFTYADR D+YWSGY+TSRP++K++DRVL HY+R+AE+ A +GM
Sbjct: 366 EFPTLSGDFFTYADRSDNYWSGYYTSRPYHKRMDRVLMHYVRAAEM--LSAWHSWDGM-- 421
Query: 1767 AKIFEKLVTARRALSLFQHHDGVTGTAKDHVVLDYGQKMIDALNACEDILSEALVVLLGI 1588
A+I E+L ARR LSLFQHHDG+TGTAK HVV+DY Q+M +AL AC+ ++ +++ LL
Sbjct: 422 ARIEERLEQARRELSLFQHHDGITGTAKTHVVVDYEQRMQEALKACQMVMQQSVYRLLTK 481
Query: 1587 DST-------NKMQMDEHR--------------VNENLLPEKRVYKIGQNVVLFNTLSRN 1471
S + +D+ R + E++LP K +VV+ NTL
Sbjct: 482 PSIYSPDFSFSYFTLDDSRWPGSGVEDSRTTIILGEDILPSK-------HVVMHNTLPHW 534
Query: 1470 RNEPICIQVDSLDAGVE--ADPPIKKQQVSPVIAYDEEKKTLVV----KNGIFELCFMLS 1309
R + + V S V A+ P+ + QVSPV ++ + T + + + F
Sbjct: 535 REQLVDFYVSSPFVSVTDLANNPV-EAQVSPVWSWHHDTLTKTIHPQGSTTKYRIIFKAR 593
Query: 1308 LGPMESVSFRLV------KNTTTSKVEIITNNAAXXXXXXXXXXXXSGD---FTVKNDKV 1156
+ PM ++ L ++T+ + ++ N GD +++
Sbjct: 594 VPPMGLATYVLTISDSKPEHTSYASNLLLRKNPTSLPLGQYPEDVKFGDPREISLRVGNG 653
Query: 1155 EAEFDGENGMIKRATSLVDDKPIDLNSHFIHYGARKSKRKFANGNEDNPAGAYLFLPDGE 976
E G++K D + ++ F+ YG R + + +GAYLFLP+G
Sbjct: 654 PTLAFSEQGLLKSIQLTQDSPHVPVHFKFLKYGVR---------SHGDRSGAYLFLPNGP 704
Query: 975 ARELKKQSSDWILVKGEVVQKV-FATPNNDLKILQTYTLYQGLPWIDLDNEVDVRSKENF 799
A ++ ++ KG++ V P+ ++ + G P ++ N VD+ S +N
Sbjct: 705 ASPVELGQPVVLVTKGKLESSVSVGLPS----VVHQTIMRGGAP--EIRNLVDIGSLDNT 758
Query: 798 ELALRFSSSVNSGDEFFTDLNGMQMIKRRRQTKLPTQANFYPMSAGVYIEDDTTRMSIHS 619
E+ +R + ++SGD F+TDLNG+Q IKRRR KLP QAN+YP+ +G++IED TR+++ +
Sbjct: 759 EIVMRLETHIDSGDIFYTDLNGLQFIKRRRLDKLPLQANYYPIPSGMFIEDANTRLTLLT 818
Query: 618 AQALGVSSLSSGQIEIMLDRRLSSDDNRGLQQGVRDNKRTVAHFRIVIEPMSSSSGNKKE 439
Q LG SSL+SG++EIM DRRL+SDD RGL QGV DNK + +R+V+E +++ K
Sbjct: 819 GQPLGGSSLASGELEIMQDRRLASDDERGLGQGVLDNKPVLHIYRLVLEKVNNCVRPSKL 878
Query: 438 ERVGFHSHVGHLATWSLHYPLVKMI 364
G+ + H A+ SL PL K I
Sbjct: 879 HPAGYLTSAAHKASQSLLDPLDKFI 903
>gi|37928076|pdb|1QWN|A Chain A, Golgi Alpha-Mannosidase Ii Covalent
Intermediate Complex With 5-Fluoro-Gulosyl-Fluoride
Length = 1045
Score = 697 bits (1800), Expect = 0.0
Identities = 379/925 (40%), Positives = 566/925 (60%), Gaps = 37/925 (4%)
Frame = -1
Query: 3027 IAHSDLQMLDLYDTWKFENPDGGVWKQGWKIEYDAEKVKSLPRLEVIVIPHSHCDPGWIM 2848
+ + D+QML+LYD F++ DGGVWKQGW I+YD K + +L+V V+PHSH DPGWI
Sbjct: 38 VPNVDVQMLELYDRMSFKDIDGGVWKQGWNIKYDPLKYNAHHKLKVFVVPHSHNDPGWIQ 97
Query: 2847 TFEEYYNRQTRNILDGMAKHLAEKDEMRFIYAEISFFETWWRDQADEIKKKVKGYLEAGK 2668
TFEEYY T++IL +HL + EM+FI+AEIS+F ++ D + K ++K ++ G+
Sbjct: 98 TFEEYYQHDTKHILSNALRHLHDNPEMKFIWAEISYFARFYHDLGENKKLQMKSIVKNGQ 157
Query: 2667 FEIVTGGWVMTDEANAHYHSMITELFEGHEWIQNHLGKSAIPQSHWSIDPFGLSPSMPHL 2488
E VTGGWVM DEAN+H+ +++ +L EG W++ + + P + W+IDPFG SP+MP++
Sbjct: 158 LEFVTGGWVMPDEANSHWRNVLLQLTEGQTWLKQFM--NVTPTASWAIDPFGHSPTMPYI 215
Query: 2487 LTSANITNAVIQRVHYSVKRELALKKNLEFYWRQLFGSTGHPDLRSHIMPFYSYDIPHTC 2308
L + N +IQR HYSVK+ELA ++ LEF WRQ++ + G L +H+MPFYSYDIPHTC
Sbjct: 216 LQKSGFKNMLIQRTHYSVKKELAQQRQLEFLWRQIWDNKGDTALFTHMMPFYSYDIPHTC 275
Query: 2307 GPEPSVCCQFDFRRMPEGGKSCDWGIPPQKINDDNVAHRAEMIYDQYRKKSQLFKNNVIF 2128
GP+P VCCQFDF+RM G SC W +PP+ I+D NVA R++++ DQ++KK++L++ NV+
Sbjct: 276 GPDPKVCCQFDFKRMGSFGLSCPWKVPPRTISDQNVAARSDLLVDQWKKKAELYRTNVLL 335
Query: 2127 QPLGDDFRYDIDFEWNSQYENYKKLFEYMNSKSEWNVHAQFGTLSDYFKKLDTAISASGE 1948
PLGDDFR+ + EW+ Q NY++LFE++NS++ +NV AQFGTL +YF + A A
Sbjct: 336 IPLGDDFRFKQNTEWDVQRVNYERLFEHINSQAHFNVQAQFGTLQEYFDAVHQAERAGQA 395
Query: 1947 QLPTFSGDFFTYADRDDHYWSGYFTSRPFYKQLDRVLQHYLRSAEIAFTLANIEEEGMVE 1768
+ PT SGDFFTYADR D+YWSGY+TSRP++K++DRVL HY+R+AE+ A +GM
Sbjct: 396 EFPTLSGDFFTYADRSDNYWSGYYTSRPYHKRMDRVLMHYVRAAEM--LSAWHSWDGM-- 451
Query: 1767 AKIFEKLVTARRALSLFQHHDGVTGTAKDHVVLDYGQKMIDALNACEDILSEALVVLLGI 1588
A+I E+L ARR LSLFQHHDG+TGTAK HVV+DY Q+M +AL AC+ ++ +++ LL
Sbjct: 452 ARIEERLEQARRELSLFQHHDGITGTAKTHVVVDYEQRMQEALKACQMVMQQSVYRLLTK 511
Query: 1587 DST-------NKMQMDEHR--------------VNENLLPEKRVYKIGQNVVLFNTLSRN 1471
S + +D+ R + E++LP K +VV+ NTL
Sbjct: 512 PSIYSPDFSFSYFTLDDSRWPGSGVEDSRTTIILGEDILPSK-------HVVMHNTLPHW 564
Query: 1470 RNEPICIQVDSLDAGVE--ADPPIKKQQVSPVIAYDEEKKTLVV----KNGIFELCFMLS 1309
R + + V S V A+ P+ + QVSPV ++ + T + + + F
Sbjct: 565 REQLVDFYVSSPFVSVTDLANNPV-EAQVSPVWSWHHDTLTKTIHPQGSTTKYRIIFKAR 623
Query: 1308 LGPMESVSFRLV------KNTTTSKVEIITNNAAXXXXXXXXXXXXSGD---FTVKNDKV 1156
+ PM ++ L ++T+ + ++ N GD +++
Sbjct: 624 VPPMGLATYVLTISDSKPEHTSYASNLLLRKNPTSLPLGQYPEDVKFGDPREISLRVGNG 683
Query: 1155 EAEFDGENGMIKRATSLVDDKPIDLNSHFIHYGARKSKRKFANGNEDNPAGAYLFLPDGE 976
E G++K D + ++ F+ YG R + + +GAYLFLP+G
Sbjct: 684 PTLAFSEQGLLKSIQLTQDSPHVPVHFKFLKYGVR---------SHGDRSGAYLFLPNGP 734
Query: 975 ARELKKQSSDWILVKGEVVQKV-FATPNNDLKILQTYTLYQGLPWIDLDNEVDVRSKENF 799
A ++ ++ KG++ V P+ ++ + G P ++ N VD+ S +N
Sbjct: 735 ASPVELGQPVVLVTKGKLESSVSVGLPS----VVHQTIMRGGAP--EIRNLVDIGSLDNT 788
Query: 798 ELALRFSSSVNSGDEFFTDLNGMQMIKRRRQTKLPTQANFYPMSAGVYIEDDTTRMSIHS 619
E+ +R + ++SGD F+TDLNG+Q IKRRR KLP QAN+YP+ +G++IED TR+++ +
Sbjct: 789 EIVMRLETHIDSGDIFYTDLNGLQFIKRRRLDKLPLQANYYPIPSGMFIEDANTRLTLLT 848
Query: 618 AQALGVSSLSSGQIEIMLDRRLSSDDNRGLQQGVRDNKRTVAHFRIVIEPMSSSSGNKKE 439
Q LG SSL+SG++EIM DRRL+SDD RGL QGV DNK + +R+V+E +++ K
Sbjct: 849 GQPLGGSSLASGELEIMQDRRLASDDERGLGQGVLDNKPVLHIYRLVLEKVNNCVRPSKL 908
Query: 438 ERVGFHSHVGHLATWSLHYPLVKMI 364
G+ + H A+ SL PL K I
Sbjct: 909 HPAGYLTSAAHKASQSLLDPLDKFI 933
>gi|40889325|pdb|1PS3|A Chain A, Golgi Alpha-Mannosidase Ii In Complex
With Kifunensine
Length = 1045
Score = 697 bits (1800), Expect = 0.0
Identities = 379/925 (40%), Positives = 566/925 (60%), Gaps = 37/925 (4%)
Frame = -1
Query: 3027 IAHSDLQMLDLYDTWKFENPDGGVWKQGWKIEYDAEKVKSLPRLEVIVIPHSHCDPGWIM 2848
+ + D+QML+LYD F++ DGGVWKQGW I+YD K + +L+V V+PHSH DPGWI
Sbjct: 38 VPNVDVQMLELYDRMSFKDIDGGVWKQGWNIKYDPLKYNAHHKLKVFVVPHSHNDPGWIQ 97
Query: 2847 TFEEYYNRQTRNILDGMAKHLAEKDEMRFIYAEISFFETWWRDQADEIKKKVKGYLEAGK 2668
TFEEYY T++IL +HL + EM+FI+AEIS+F ++ D + K ++K ++ G+
Sbjct: 98 TFEEYYQHDTKHILSNALRHLHDNPEMKFIWAEISYFARFYHDLGENKKLQMKSIVKNGQ 157
Query: 2667 FEIVTGGWVMTDEANAHYHSMITELFEGHEWIQNHLGKSAIPQSHWSIDPFGLSPSMPHL 2488
E VTGGWVM DEAN+H+ +++ +L EG W++ + + P + W+IDPFG SP+MP++
Sbjct: 158 LEFVTGGWVMPDEANSHWRNVLLQLTEGQTWLKQFM--NVTPTASWAIDPFGHSPTMPYI 215
Query: 2487 LTSANITNAVIQRVHYSVKRELALKKNLEFYWRQLFGSTGHPDLRSHIMPFYSYDIPHTC 2308
L + N +IQR HYSVK+ELA ++ LEF WRQ++ + G L +H+MPFYSYDIPHTC
Sbjct: 216 LQKSGFKNMLIQRTHYSVKKELAQQRQLEFLWRQIWDNKGDTALFTHMMPFYSYDIPHTC 275
Query: 2307 GPEPSVCCQFDFRRMPEGGKSCDWGIPPQKINDDNVAHRAEMIYDQYRKKSQLFKNNVIF 2128
GP+P VCCQFDF+RM G SC W +PP+ I+D NVA R++++ DQ++KK++L++ NV+
Sbjct: 276 GPDPKVCCQFDFKRMGSFGLSCPWKVPPRTISDQNVAARSDLLVDQWKKKAELYRTNVLL 335
Query: 2127 QPLGDDFRYDIDFEWNSQYENYKKLFEYMNSKSEWNVHAQFGTLSDYFKKLDTAISASGE 1948
PLGDDFR+ + EW+ Q NY++LFE++NS++ +NV AQFGTL +YF + A A
Sbjct: 336 IPLGDDFRFKQNTEWDVQRVNYERLFEHINSQAHFNVQAQFGTLQEYFDAVHQAERAGQA 395
Query: 1947 QLPTFSGDFFTYADRDDHYWSGYFTSRPFYKQLDRVLQHYLRSAEIAFTLANIEEEGMVE 1768
+ PT SGDFFTYADR D+YWSGY+TSRP++K++DRVL HY+R+AE+ A +GM
Sbjct: 396 EFPTLSGDFFTYADRSDNYWSGYYTSRPYHKRMDRVLMHYVRAAEM--LSAWHSWDGM-- 451
Query: 1767 AKIFEKLVTARRALSLFQHHDGVTGTAKDHVVLDYGQKMIDALNACEDILSEALVVLLGI 1588
A+I E+L ARR LSLFQHHDG+TGTAK HVV+DY Q+M +AL AC+ ++ +++ LL
Sbjct: 452 ARIEERLEQARRELSLFQHHDGITGTAKTHVVVDYEQRMQEALKACQMVMQQSVYRLLTK 511
Query: 1587 DST-------NKMQMDEHR--------------VNENLLPEKRVYKIGQNVVLFNTLSRN 1471
S + +D+ R + E++LP K +VV+ NTL
Sbjct: 512 PSIYSPDFSFSYFTLDDSRWPGSGVEDSRTTIILGEDILPSK-------HVVMHNTLPHW 564
Query: 1470 RNEPICIQVDSLDAGVE--ADPPIKKQQVSPVIAYDEEKKTLVV----KNGIFELCFMLS 1309
R + + V S V A+ P+ + QVSPV ++ + T + + + F
Sbjct: 565 REQLVDFYVSSPFVSVTDLANNPV-EAQVSPVWSWHHDTLTKTIHPQGSTTKYRIIFKAR 623
Query: 1308 LGPMESVSFRLV------KNTTTSKVEIITNNAAXXXXXXXXXXXXSGD---FTVKNDKV 1156
+ PM ++ L ++T+ + ++ N GD +++
Sbjct: 624 VPPMGLATYVLTISDSKPEHTSYASNLLLRKNPTSLPLGQYPEDVKFGDPREISLRVGNG 683
Query: 1155 EAEFDGENGMIKRATSLVDDKPIDLNSHFIHYGARKSKRKFANGNEDNPAGAYLFLPDGE 976
E G++K D + ++ F+ YG R + + +GAYLFLP+G
Sbjct: 684 PTLAFSEQGLLKSIQLTQDSPHVPVHFKFLKYGVR---------SHGDRSGAYLFLPNGP 734
Query: 975 ARELKKQSSDWILVKGEVVQKV-FATPNNDLKILQTYTLYQGLPWIDLDNEVDVRSKENF 799
A ++ ++ KG++ V P+ ++ + G P ++ N VD+ S +N
Sbjct: 735 ASPVELGQPVVLVTKGKLESSVSVGLPS----VVHQTIMRGGAP--EIRNLVDIGSLDNT 788
Query: 798 ELALRFSSSVNSGDEFFTDLNGMQMIKRRRQTKLPTQANFYPMSAGVYIEDDTTRMSIHS 619
E+ +R + ++SGD F+TDLNG+Q IKRRR KLP QAN+YP+ +G++IED TR+++ +
Sbjct: 789 EIVMRLETHIDSGDIFYTDLNGLQFIKRRRLDKLPLQANYYPIPSGMFIEDANTRLTLLT 848
Query: 618 AQALGVSSLSSGQIEIMLDRRLSSDDNRGLQQGVRDNKRTVAHFRIVIEPMSSSSGNKKE 439
Q LG SSL+SG++EIM DRRL+SDD RGL QGV DNK + +R+V+E +++ K
Sbjct: 849 GQPLGGSSLASGELEIMQDRRLASDDERGLGQGVLDNKPVLHIYRLVLEKVNNCVRPSKL 908
Query: 438 ERVGFHSHVGHLATWSLHYPLVKMI 364
G+ + H A+ SL PL K I
Sbjct: 909 HPAGYLTSAAHKASQSLLDPLDKFI 933
>gi|37928081|pdb|1QWU|A Chain A, Golgi Alpha-Mannosidase Ii D341n
Mutant Complex With 5-F- Guloside
gi|37928083|pdb|1QX1|A Chain A, Golgi Alpha-Mannosidase Ii D341n
Mutant Complex With 2-F- Mannosyl-F
Length = 1045
Score = 696 bits (1795), Expect = 0.0
Identities = 378/925 (40%), Positives = 566/925 (60%), Gaps = 37/925 (4%)
Frame = -1
Query: 3027 IAHSDLQMLDLYDTWKFENPDGGVWKQGWKIEYDAEKVKSLPRLEVIVIPHSHCDPGWIM 2848
+ + D+QML+LYD F++ DGGVWKQGW I+YD K + +L+V V+PHSH DPGWI
Sbjct: 38 VPNVDVQMLELYDRMSFKDIDGGVWKQGWNIKYDPLKYNAHHKLKVFVVPHSHNDPGWIQ 97
Query: 2847 TFEEYYNRQTRNILDGMAKHLAEKDEMRFIYAEISFFETWWRDQADEIKKKVKGYLEAGK 2668
TFEEYY T++IL +HL + EM+FI+AEIS+F ++ D + K ++K ++ G+
Sbjct: 98 TFEEYYQHDTKHILSNALRHLHDNPEMKFIWAEISYFARFYHDLGENKKLQMKSIVKNGQ 157
Query: 2667 FEIVTGGWVMTDEANAHYHSMITELFEGHEWIQNHLGKSAIPQSHWSIDPFGLSPSMPHL 2488
E VTGGWVM DEAN+H+ +++ +L EG W++ + + P + W+IDPFG SP+MP++
Sbjct: 158 LEFVTGGWVMPDEANSHWRNVLLQLTEGQTWLKQFM--NVTPTASWAIDPFGHSPTMPYI 215
Query: 2487 LTSANITNAVIQRVHYSVKRELALKKNLEFYWRQLFGSTGHPDLRSHIMPFYSYDIPHTC 2308
L + N +IQR HYSVK+ELA ++ LEF WRQ++ + G L +H+MPFYSYDIPHTC
Sbjct: 216 LQKSGFKNMLIQRTHYSVKKELAQQRQLEFLWRQIWDNKGDTALFTHMMPFYSYDIPHTC 275
Query: 2307 GPEPSVCCQFDFRRMPEGGKSCDWGIPPQKINDDNVAHRAEMIYDQYRKKSQLFKNNVIF 2128
GP+P VCCQFDF+RM G SC W +PP+ I+D NVA R++++ DQ++KK++L++ NV+
Sbjct: 276 GPDPKVCCQFDFKRMGSFGLSCPWKVPPRTISDQNVAARSDLLVDQWKKKAELYRTNVLL 335
Query: 2127 QPLGDDFRYDIDFEWNSQYENYKKLFEYMNSKSEWNVHAQFGTLSDYFKKLDTAISASGE 1948
PLGD+FR+ + EW+ Q NY++LFE++NS++ +NV AQFGTL +YF + A A
Sbjct: 336 IPLGDNFRFKQNTEWDVQRVNYERLFEHINSQAHFNVQAQFGTLQEYFDAVHQAERAGQA 395
Query: 1947 QLPTFSGDFFTYADRDDHYWSGYFTSRPFYKQLDRVLQHYLRSAEIAFTLANIEEEGMVE 1768
+ PT SGDFFTYADR D+YWSGY+TSRP++K++DRVL HY+R+AE+ A +GM
Sbjct: 396 EFPTLSGDFFTYADRSDNYWSGYYTSRPYHKRMDRVLMHYVRAAEM--LSAWHSWDGM-- 451
Query: 1767 AKIFEKLVTARRALSLFQHHDGVTGTAKDHVVLDYGQKMIDALNACEDILSEALVVLLGI 1588
A+I E+L ARR LSLFQHHDG+TGTAK HVV+DY Q+M +AL AC+ ++ +++ LL
Sbjct: 452 ARIEERLEQARRELSLFQHHDGITGTAKTHVVVDYEQRMQEALKACQMVMQQSVYRLLTK 511
Query: 1587 DST-------NKMQMDEHR--------------VNENLLPEKRVYKIGQNVVLFNTLSRN 1471
S + +D+ R + E++LP K +VV+ NTL
Sbjct: 512 PSIYSPDFSFSYFTLDDSRWPGSGVEDSRTTIILGEDILPSK-------HVVMHNTLPHW 564
Query: 1470 RNEPICIQVDSLDAGVE--ADPPIKKQQVSPVIAYDEEKKTLVV----KNGIFELCFMLS 1309
R + + V S V A+ P+ + QVSPV ++ + T + + + F
Sbjct: 565 REQLVDFYVSSPFVSVTDLANNPV-EAQVSPVWSWHHDTLTKTIHPQGSTTKYRIIFKAR 623
Query: 1308 LGPMESVSFRLV------KNTTTSKVEIITNNAAXXXXXXXXXXXXSGD---FTVKNDKV 1156
+ PM ++ L ++T+ + ++ N GD +++
Sbjct: 624 VPPMGLATYVLTISDSKPEHTSYASNLLLRKNPTSLPLGQYPEDVKFGDPREISLRVGNG 683
Query: 1155 EAEFDGENGMIKRATSLVDDKPIDLNSHFIHYGARKSKRKFANGNEDNPAGAYLFLPDGE 976
E G++K D + ++ F+ YG R + + +GAYLFLP+G
Sbjct: 684 PTLAFSEQGLLKSIQLTQDSPHVPVHFKFLKYGVR---------SHGDRSGAYLFLPNGP 734
Query: 975 ARELKKQSSDWILVKGEVVQKV-FATPNNDLKILQTYTLYQGLPWIDLDNEVDVRSKENF 799
A ++ ++ KG++ V P+ ++ + G P ++ N VD+ S +N
Sbjct: 735 ASPVELGQPVVLVTKGKLESSVSVGLPS----VVHQTIMRGGAP--EIRNLVDIGSLDNT 788
Query: 798 ELALRFSSSVNSGDEFFTDLNGMQMIKRRRQTKLPTQANFYPMSAGVYIEDDTTRMSIHS 619
E+ +R + ++SGD F+TDLNG+Q IKRRR KLP QAN+YP+ +G++IED TR+++ +
Sbjct: 789 EIVMRLETHIDSGDIFYTDLNGLQFIKRRRLDKLPLQANYYPIPSGMFIEDANTRLTLLT 848
Query: 618 AQALGVSSLSSGQIEIMLDRRLSSDDNRGLQQGVRDNKRTVAHFRIVIEPMSSSSGNKKE 439
Q LG SSL+SG++EIM DRRL+SDD RGL QGV DNK + +R+V+E +++ K
Sbjct: 849 GQPLGGSSLASGELEIMQDRRLASDDERGLGQGVLDNKPVLHIYRLVLEKVNNCVRPSKL 908
Query: 438 ERVGFHSHVGHLATWSLHYPLVKMI 364
G+ + H A+ SL PL K I
Sbjct: 909 HPAGYLTSAAHKASQSLLDPLDKFI 933
>gi|31231176|ref|XP_318477.1| ENSANGP00000014255 [Anopheles gambiae]
gi|30174942|gb|EAA13579.2| ENSANGP00000014255 [Anopheles gambiae str.
PEST]
Length = 1128
Score = 682 bits (1761), Expect = 0.0
Identities = 396/997 (39%), Positives = 563/997 (55%), Gaps = 36/997 (3%)
Frame = -1
Query: 3051 CGIRENVSIAHSDLQMLDLYDTWKFENPDGGVWKQGWKIEYDAEKVKSLPRLEVIVIPHS 2872
C +R ++ I D+QML+LY+ FEN DGGVWKQGW I+Y + S +L V V+PHS
Sbjct: 140 CALRTDI-IPQPDVQMLNLYEQVSFENIDGGVWKQGWPIKYHPSEWNSHHKLHVFVVPHS 198
Query: 2871 HCDPGWIMTFEEYYNRQTRNILDGMAKHLAEKDEMRFIYAEISFFETWWRDQADEIKKKV 2692
H DPGWI TF+EYY R T+NI M +HL E MRFI+AEIS+F W+ A E K V
Sbjct: 199 HNDPGWIQTFDEYYERSTKNIFANMLRHLDENAGMRFIWAEISYFAQWYDKLAAEQKDIV 258
Query: 2691 KGYLEAGKFEIVTGGWVMTDEANAHYHSMITELFEGHEWIQNHLGKSAIPQSHWSIDPFG 2512
K ++ + E VTGGWVM DEAN+H++SM+ +L EG W+Q L + P S WSIDPFG
Sbjct: 259 KRLVKKRQLEFVTGGWVMPDEANSHWYSMLLQLTEGQTWLQTRL--NVTPVSSWSIDPFG 316
Query: 2511 LSPSMPHLLTSANITNAVIQRVHYSVKRELALKKNLEFYWRQLFGSTGHPDLRSHIMPFY 2332
S +MP++L + N +IQR HY VK+ LALKK LEF WRQL+ + G DL +H+MPFY
Sbjct: 317 QSATMPYILKQSGFENLLIQRTHYIVKKNLALKKQLEFRWRQLWDTRGDTDLFTHMMPFY 376
Query: 2331 SYDIPHTCGPEPSVCCQFDFRRMPEGGKSCDWGIPPQKINDDNVAHRAEMIYDQYRKKSQ 2152
SYD+PHTCGP+P +CCQFDF+R+P G SC W +PP+ I D NVA RAEMI DQ+RKKS
Sbjct: 377 SYDVPHTCGPDPKICCQFDFKRLPSMGLSCPWNVPPKPITDQNVAERAEMIVDQWRKKSV 436
Query: 2151 LFKNNVIFQPLGDDFRYDIDFEWNSQYENYKKLFEYMNSKSEWNVHAQFGTLSDYFKKLD 1972
L++ + PLGDDFRY EW +Q N+++LF Y+N++ NV A+F TL DYF +
Sbjct: 437 LYRTRNVLIPLGDDFRYTTSSEWEAQRVNFEQLFNYINNEPSLNVEAKFATLQDYFDAVR 496
Query: 1971 TAISASG-EQLPTFSGDFFTYADRDDHYWSGYFTSRPFYKQLDRVLQHYLRSAEIAFTLA 1795
+ ASG EQ P+ +GDFFTYAD + YWSGYFTSRP++K+ DR+L HY+RSAE+
Sbjct: 497 STSGASGMEQFPSLTGDFFTYADVNQDYWSGYFTSRPYHKRQDRILLHYIRSAEMLHAW- 555
Query: 1794 NIEEEGMVEAKIFEKLVTARRALSLFQHHDGVTGTAKDHVVLDYGQKMIDALNACEDILS 1615
N+ E + E+L ARR LSLFQHHDG+TGTAKDHV+ DY ++M A+ C+ ++
Sbjct: 556 NVWEPDSDWKPLAERLEYARRQLSLFQHHDGITGTAKDHVMEDYAKRMSRAIEDCKFVMQ 615
Query: 1614 EALVVLLGIDSTNK-------MQMDEHRV---NENLLPEKRVYK--IGQNVVLFNTLSRN 1471
+++ LL S + + +D+ R ++N+ P + + + VVL N+L
Sbjct: 616 QSVYRLLTKPSVYQPDPAFMYLSIDDSRTVNGSDNVRPTIILGEELPSKQVVLHNSLPYT 675
Query: 1470 RNEPICIQVDSLDAGV-EADPPIKKQQVSPVIAYDEEKKTL---VVKNGIFELCFMLSLG 1303
R+E + V S V + + Q++PV ++ ++ N + L F ++
Sbjct: 676 RSEVVEFYVASPFVTVLDGNGGTVPSQIAPVWSWHTRPDSISQPQPSNTKYRLLFRANVP 735
Query: 1302 PM--------------ESVSFRLVKNTTTSKVEIITNNAAXXXXXXXXXXXXSGDFTVKN 1165
P+ ES+ K SK N AA +
Sbjct: 736 PLGLSVYTINSKNSAEESLGVTYTKVIILSKSPFTVNLAAGYPEDIDHASPTEMSLRFEE 795
Query: 1164 DKVEAEFDGENGMIKRATSLVDDKPIDLNSHFIHYGARKSKRKFANGNEDNPAGAYLFLP 985
+ G++K T + + ++ F YG + S K +GAYLF P
Sbjct: 796 GGSTSAAFTSKGLLKSLTIENNQATVPVHLEFYRYGMQLSSGK---------SGAYLFHP 846
Query: 984 DGEARELKKQSSDWILVKGEVVQKVFATPNNDLKILQTYTLYQGLPWIDLDNEVDVRSKE 805
G A + +++KG + + T + QT +++ N VD+ ++
Sbjct: 847 AGNATLMTYDQPIVLVMKGPLETSI--TAGLPFAVHQTILRDDS---VEIRNLVDIGQRD 901
Query: 804 NFELALRFSSSVNSGDEFFTDLNGMQMIKRRRQTKLPTQANFYPMSAGVYIEDDTTRMSI 625
N E+ +R +++NSG F+TDLNGMQ+IKR+R KLP QAN+YP+ + ++IEDD R+++
Sbjct: 902 NTEIVMRLQTNINSGATFYTDLNGMQIIKRKRFQKLPIQANYYPVPSTMFIEDDNYRLTL 961
Query: 624 HSAQALGVSSLSSGQIEIMLDRRLSSDDNRGLQQGVRDNKRTVAHFRIVIEPMSSSSGNK 445
Q LG SSLSSG++EIM DRRL+ DD+RGL QGV+DN + FR+V+E S +
Sbjct: 962 LGGQPLGGSSLSSGEMEIMQDRRLTRDDDRGLGQGVQDNLPVLHLFRLVLESRESCTKPD 1021
Query: 444 KEERVGFHSHVGHLATWSLHYPLVKMI---GDATPKSISSKNVEQE-LNCDLHLVTFRTL 277
+ GF + H SL +PL K+I D T + E L L +V R L
Sbjct: 1022 PDYPTGFLTLPAHAQLQSLLHPLDKLIYNENDWTGVQMEGFGSRHEPLEQGLEVVAIRQL 1081
Query: 276 ASPTTYEANERSTAAEKKAAMVMHRV-VPDCRSRLTL 169
+ + T+ +++HR DC S +
Sbjct: 1082 S-----HVHFGRTSGASPVGLIVHRTNFEDCGSEANM 1113
>gi|25529601|pir||JC4037 alpha-mannosidase II, Golgi - fruit fly
(Drosophila melanogaster)
Length = 1108
Score = 667 bits (1721), Expect = 0.0
Identities = 396/1060 (37%), Positives = 596/1060 (55%), Gaps = 39/1060 (3%)
Frame = -1
Query: 3426 KRNFYIILCLGVFLT-VSLYLYNGIETGAEALTKRQANDLRRKIGNLEHVAEENGRTIDR 3250
+R F +++C G L +SLY+ A K ++ K+ LE+ +E+G +
Sbjct: 5 RRRFALVICSGCLLVFLSLYIILNFAAPAATQIKPNYENIENKLHELENGLQEHGEEMRN 64
Query: 3249 LEQEVQRAKAEKSVDFDXXXXXXXXXXXXXXXXXVAPVPVRGNRGEMAHIHQVKQHIKPT 3070
L RA+ K+ + D P+R +K P
Sbjct: 65 L-----RARLAKTSNRDD--------------------PIRP---------PLKVARSPR 90
Query: 3069 PSM-KDVCGIRENVSIAHSDLQMLDLYDTWKFENPDGGVWKQGWKIEYDAEKVKSLPRLE 2893
P +DV NV D+QML+LYD F++ DGGVWKQGW I+YD K + +L+
Sbjct: 91 PGQCQDVVQDVPNV-----DVQMLELYDRMSFKDIDGGVWKQGWNIKYDPLKYNAHHKLK 145
Query: 2892 VIVIPHSHCDPGWIMTFEEYYNRQTRNILDGMAKHLAEKDEMRFIYAEISFFETWWRDQA 2713
V V+PHSH DPGWI TFEEYY T++IL +HL + EM+FI+AEIS+F ++ D
Sbjct: 146 VFVVPHSHNDPGWIQTFEEYYQHDTKHILSNALRHLHDNPEMKFIWAEISYFARFYHDLG 205
Query: 2712 DEIKKKVKGYLEAGKFEIVTGGWVMTDEANAHYHSMITELFEGHEWIQNHLGKSAIPQSH 2533
+ K ++K ++ G+ E VTGGWVM DEAN+H+ +++ +L EG W++ + + P +
Sbjct: 206 ENKKLQMKSIVKNGQLEFVTGGWVMPDEANSHWRNVLLQLTEGQTWLKQFM--NVTPTAS 263
Query: 2532 WSIDPFGLSPSMPHLLTSANITNAVIQRVHYSVKRELALKKNLEFYWRQLFGSTGHPDLR 2353
W+IDPFG SP+MP++L + N +IQR HYSVK+ELA ++ LEF WRQ++ + G L
Sbjct: 264 WAIDPFGHSPTMPYILQKSGFKNMLIQRTHYSVKKELAQQRQLEFLWRQIWDNKGDTALF 323
Query: 2352 SHIMPFYSYDIPHTCGPEPSVCCQFDFRRMPEGGKSCDWGIPPQKINDDNVAHRAEMIYD 2173
+H+MPFYSYDIPHTCGP+P VCCQFDF+RM G SC W +PP+ I+D NVA R++++ D
Sbjct: 324 THMMPFYSYDIPHTCGPDPKVCCQFDFKRMGSFGLSCPWKVPPRTISDQNVAARSDLLVD 383
Query: 2172 QYRKKSQLFKNNVIFQPLGDDFRYDIDFEWNSQYENYKKLFEYMNSKSEWNVHAQFGTLS 1993
Q++KK++L++ NV+ PLGDDFR+ + EW+ Q NY++LFE++NS++ +NV AQFGTL
Sbjct: 384 QWKKKAELYRTNVLLIPLGDDFRFKQNTEWDVQRVNYERLFEHINSQAHFNVQAQFGTLQ 443
Query: 1992 DYFKKLDTAISASGEQLPTFSGDFFTYADRDDHYWSGYFTSRPFYKQLDRVLQHYLRSAE 1813
+YF + A A + PT SGDFFTYADR D+YWSGY+TSRP++K++DRVL HY+R+AE
Sbjct: 444 EYFDAVHQAERAGQAEFPTLSGDFFTYADRSDNYWSGYYTSRPYHKRMDRVLMHYVRAAE 503
Query: 1812 IAFTLANIEEEGMVEAKIFEKLVTARRALSLFQHHDGVTGTAKDHVVLDYGQKMIDALNA 1633
+ A +GM A+I E+L ARR LSLFQHHDG+TGTAK HVV+DY Q+M +AL A
Sbjct: 504 M--LSAWHSWDGM--ARIEERLEQARRELSLFQHHDGITGTAKTHVVVDYEQRMQEALKA 559
Query: 1632 CEDILSEALVVLLGIDST-------NKMQMDEHR--------------VNENLLPEKRVY 1516
C+ ++ +++ LL S + +D+ R + E++LP K
Sbjct: 560 CQMVMQQSVYRLLTKPSIYSPDFSFSYFTLDDSRWPGSGVEDSRTTIILGEDILPSK--- 616
Query: 1515 KIGQNVVLFNTLSRNRNEPICIQVDSLDAGVE--ADPPIKKQQVSPVIAYDEEKKTLVV- 1345
+VV+ NTL R + + V S V A+ P+ + QVSPV ++ + T +
Sbjct: 617 ----HVVMHNTLPHWREQLVDFYVSSPFVSVTDLANNPV-EAQVSPVWSWHHDTLTKTIH 671
Query: 1344 ---KNGIFELCFMLSLGPMESVSFRLV------KNTTTSKVEIITNNAAXXXXXXXXXXX 1192
+ + F + PM ++ L ++T+ + ++ N
Sbjct: 672 PQGSTTKYRIIFKARVPPMGLATYVLTISDSKPEHTSYASNLLLRKNPTSLPLGQYPEDV 731
Query: 1191 XSGD---FTVKNDKVEAEFDGENGMIKRATSLVDDKPIDLNSHFIHYGARKSKRKFANGN 1021
GD +++ E G++K D + ++ F+ YG R +
Sbjct: 732 KFGDPREISLRVGNGPTLAFSEQGLLKSIQLTQDSPHVPVHFKFLKYGVR---------S 782
Query: 1020 EDNPAGAYLFLPDGEARELKKQSSDWILVKGEVVQKV-FATPNNDLKILQTYTLYQGLPW 844
+ +GAYLFLP+G A ++ ++ KG++ V P+ ++ + G P
Sbjct: 783 HGDRSGAYLFLPNGPASPVELGQPVVLVTKGKLESSVSVGLPS----VVHQTIMRGGAP- 837
Query: 843 IDLDNEVDVRSKENFELALRFSSSVNSGDEFFTDLNGMQMIKRRRQTKLPTQANFYPMSA 664
++ N VD+ S +N E+ +R + ++SGD F+TDLNG+Q IKRRR KLP QAN+YP+ +
Sbjct: 838 -EIRNLVDIGSLDNTEIVMRLETHIDSGDIFYTDLNGLQFIKRRRLDKLPLQANYYPIPS 896
Query: 663 GVYIEDDTTRMSIHSAQALGVSSLSSGQIEIMLDRRLSSDDNRGLQQGVRDNKRTVAHFR 484
G++IE + + L V + L RRL+SDD RGL QGV DNK + +R
Sbjct: 897 GMFIEIRRRFALVICSGCLLVFLSLYIILNFALRRRLASDDERGLGQGVLDNKPVLHIYR 956
Query: 483 IVIEPMSSSSGNKKEERVGFHSHVGHLATWSLHYPLVKMI 364
+V+E +++ K G+ + H A+ SL PL K I
Sbjct: 957 LVLEKVNNCVRPSKLHPAGYLTSAAHKASQSLLDPLDKFI 996
>gi|18158757|pdb|1HTY|A Chain A, Golgi Alpha-Mannosidase Ii
Length = 1015
Score = 667 bits (1720), Expect = 0.0
Identities = 370/925 (40%), Positives = 547/925 (59%), Gaps = 37/925 (4%)
Frame = -1
Query: 3027 IAHSDLQMLDLYDTWKFENPDGGVWKQGWKIEYDAEKVKSLPRLEVIVIPHSHCDPGWIM 2848
+ + D+Q L+LYD F++ DGGVWKQGW I+YD K + +L+V V+PHSH DPGWI
Sbjct: 8 VPNVDVQXLELYDRXSFKDIDGGVWKQGWNIKYDPLKYNAHHKLKVFVVPHSHNDPGWIQ 67
Query: 2847 TFEEYYNRQTRNILDGMAKHLAEKDEMRFIYAEISFFETWWRDQADEIKKKVKGYLEAGK 2668
TFEEYY T++IL +HL + E +FI+AEIS+F ++ D + K + K ++ G+
Sbjct: 68 TFEEYYQHDTKHILSNALRHLHDNPEXKFIWAEISYFARFYHDLGENKKLQXKSIVKNGQ 127
Query: 2667 FEIVTGGWVMTDEANAHYHSMITELFEGHEWIQNHLGKSAIPQSHWSIDPFGLSPSMPHL 2488
E VTGGWV DEAN+H+ +++ +L EG W++ + P + W+IDPFG SP+ P++
Sbjct: 128 LEFVTGGWVXPDEANSHWRNVLLQLTEGQTWLKQFX--NVTPTASWAIDPFGHSPTXPYI 185
Query: 2487 LTSANITNAVIQRVHYSVKRELALKKNLEFYWRQLFGSTGHPDLRSHIMPFYSYDIPHTC 2308
L + N +IQR HYSVK+ELA ++ LEF WRQ++ + G L +H PFYSYDIPHTC
Sbjct: 186 LQKSGFKNMLIQRTHYSVKKELAQQRQLEFLWRQIWDNKGDTALFTHXXPFYSYDIPHTC 245
Query: 2307 GPEPSVCCQFDFRRMPEGGKSCDWGIPPQKINDDNVAHRAEMIYDQYRKKSQLFKNNVIF 2128
GP+P VCCQFDF+R G SC W +PP+ I+D NVA R++++ DQ++KK++L++ NV+
Sbjct: 246 GPDPKVCCQFDFKRXGSFGLSCPWKVPPRTISDQNVAARSDLLVDQWKKKAELYRTNVLL 305
Query: 2127 QPLGDDFRYDIDFEWNSQYENYKKLFEYMNSKSEWNVHAQFGTLSDYFKKLDTAISASGE 1948
PLGDDFR+ + EW+ Q NY++LFE++NS++ +NV AQFGTL +YF + A A
Sbjct: 306 IPLGDDFRFKQNTEWDVQRVNYERLFEHINSQAHFNVQAQFGTLQEYFDAVHQAERAGQA 365
Query: 1947 QLPTFSGDFFTYADRDDHYWSGYFTSRPFYKQLDRVLQHYLRSAEIAFTLANIEEEGMVE 1768
+ PT SGDFFTYADR D+YWSGY+TSRP++K+ DRVL HY+R+AE A +GM
Sbjct: 366 EFPTLSGDFFTYADRSDNYWSGYYTSRPYHKRXDRVLXHYVRAAE--XLSAWHSWDGM-- 421
Query: 1767 AKIFEKLVTARRALSLFQHHDGVTGTAKDHVVLDYGQKMIDALNACEDILSEALVVLLGI 1588
A+I E+L ARR LSLFQHHDG+TGTAK HVV+DY Q+ +AL AC+ + +++ LL
Sbjct: 422 ARIEERLEQARRELSLFQHHDGITGTAKTHVVVDYEQRXQEALKACQXVXQQSVYRLLTK 481
Query: 1587 DST-------NKMQMDEHR--------------VNENLLPEKRVYKIGQNVVLFNTLSRN 1471
S + +D+ R + E++LP K +VV NTL
Sbjct: 482 PSIYSPDFSFSYFTLDDSRWPGSGVEDSRTTIILGEDILPSK-------HVVXHNTLPHW 534
Query: 1470 RNEPICIQVDSLDAGVE--ADPPIKKQQVSPVIAYDEEKKTLVV----KNGIFELCFMLS 1309
R + + V S V A+ P+ + QVSPV ++ + T + + + F
Sbjct: 535 REQLVDFYVSSPFVSVTDLANNPV-EAQVSPVWSWHHDTLTKTIHPQGSTTKYRIIFKAR 593
Query: 1308 LGPMESVSFRLV------KNTTTSKVEIITNNAAXXXXXXXXXXXXSGD---FTVKNDKV 1156
+ P ++ L ++T+ + ++ N GD +++
Sbjct: 594 VPPXGLATYVLTISDSKPEHTSYASNLLLRKNPTSLPLGQYPEDVKFGDPREISLRVGNG 653
Query: 1155 EAEFDGENGMIKRATSLVDDKPIDLNSHFIHYGARKSKRKFANGNEDNPAGAYLFLPDGE 976
E G++K D + ++ F+ YG R + + +GAYLFLP+G
Sbjct: 654 PTLAFSEQGLLKSIQLTQDSPHVPVHFKFLKYGVR---------SHGDRSGAYLFLPNGP 704
Query: 975 ARELKKQSSDWILVKGEVVQKV-FATPNNDLKILQTYTLYQGLPWIDLDNEVDVRSKENF 799
A ++ ++ KG++ V P+ ++ G P ++ N VD+ S +N
Sbjct: 705 ASPVELGQPVVLVTKGKLESSVSVGLPS----VVHQTIXRGGAP--EIRNLVDIGSLDNT 758
Query: 798 ELALRFSSSVNSGDEFFTDLNGMQMIKRRRQTKLPTQANFYPMSAGVYIEDDTTRMSIHS 619
E+ R + ++SGD F+TDLNG+Q IKRRR KLP QAN+YP+ +G +IED TR+++ +
Sbjct: 759 EIVXRLETHIDSGDIFYTDLNGLQFIKRRRLDKLPLQANYYPIPSGXFIEDANTRLTLLT 818
Query: 618 AQALGVSSLSSGQIEIMLDRRLSSDDNRGLQQGVRDNKRTVAHFRIVIEPMSSSSGNKKE 439
Q LG SSL+SG++EI DRRL+SDD RGL QGV DNK + +R+V+E +++ K
Sbjct: 819 GQPLGGSSLASGELEIXQDRRLASDDERGLGQGVLDNKPVLHIYRLVLEKVNNCVRPSKL 878
Query: 438 ERVGFHSHVGHLATWSLHYPLVKMI 364
G+ + H A+ SL PL K I
Sbjct: 879 HPAGYLTSAAHKASQSLLDPLDKFI 903
>gi|3123244|sp|P49641|M2A2_HUMAN Alpha-mannosidase IIx
(Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase) (MAN
IIx) (Mannosidase alpha class 2A member 2)
gi|1132479|dbj|BAA09510.1| alpha mannosidase II isozyme [Homo
sapiens]
Length = 1139
Score = 659 bits (1701), Expect = 0.0
Identities = 394/1037 (37%), Positives = 566/1037 (53%), Gaps = 39/1037 (3%)
Frame = -1
Query: 3015 DLQMLDLYDTWKFENPDGGVWKQGWKIEYDAEKVKSLPRLEVIVIPHSHCDPGWIMTFEE 2836
+LQML + + F+N DGGVW+QG+ I YD + L+V V+PHSH DPGWI TF++
Sbjct: 128 ELQMLTVSEELPFDNVDGGVWRQGFDISYDPHDWDA-EDLQVFVVPHSHNDPGWIKTFDK 186
Query: 2835 YYNRQTRNILDGMAKHLAEKDEMRFIYAEISFFETWWRDQADEIKKKVKGYLEAGKFEIV 2656
YY QT++IL+ M L E RF++AE+SFF WW + + + V+ + G+ EI
Sbjct: 187 YYTEQTQHILNSMVSKLQEDPRRRFLWAEVSFFAKWWDNINVQKRAAVRRLVGNGQLEIA 246
Query: 2655 TGGWVMTDEANAHYHSMITELFEGHEWIQNHLGKSAIPQSHWSIDPFGLSPSMPHLLTSA 2476
TGGWVM DEAN+HY ++I +L EGH+W++ +LG A P+S W++DPFG S +MP+LL A
Sbjct: 247 TGGWVMPDEANSHYFALIDQLIEGHQWLERNLG--ATPRSGWAVDPFGYSSTMPYLLRRA 304
Query: 2475 NITNAVIQRVHYSVKRELALKKNLEFYWRQLFGSTGHPDLRSHIMPFYSYDIPHTCGPEP 2296
N+T+ +IQRVHY++K+ A +LEF WRQ + S D+ H+MPFYSYD+PHTCGP+P
Sbjct: 305 NLTSMLIQRVHYAIKKHFAATHSLEFMWRQTWDSDSSTDIFCHMMPFYSYDVPHTCGPDP 364
Query: 2295 SVCCQFDFRRMPEGGKSCDWGIPPQKINDDNVAHRAEMIYDQYRKKSQLFKNNVIFQPLG 2116
+CCQFDF+R+P G +C W +PP+ I + NVA RA ++ DQYRKKSQLF++NV+ PLG
Sbjct: 365 KICCQFDFKRLPGGRINCPWKVPPRAITEANVAERAALLLDQYRKKSQLFRSNVLLVPLG 424
Query: 2115 DDFRYDIDFEWNSQYENYKKLFEYMNSKSEWNVHAQFGTLSDYF----KKLDTAISASGE 1948
DDFRYD EW++Q+ NY++LF++ NS+ +V AQFGTLSDYF K+ A
Sbjct: 425 DDFRYDKPQEWDAQFFNYQRLFDFFNSRPNLHVQAQFGTLSDYFDALYKRTGVEPGARPP 484
Query: 1947 QLPTFSGDFFTYADRDDHYWSGYFTSRPFYKQLDRVLQHYLRSAEIAFTLANIEEE---- 1780
P SGDFF+YADR+DHYW+GY+TSRPFYK LDRVL+ +LR AE+ ++LA
Sbjct: 485 GFPVLSGDFFSYADREDHYWTGYYTSRPFYKSLDRVLEAHLRGAEVLYSLAAAHARRSGL 544
Query: 1779 -GMVEAKIFEKLVTARRALSLFQHHDGVTGTAKDHVVLDYGQKMIDAL-NACEDILSEAL 1606
G F L ARR L LFQHHD +TGTAK+ VV+DYG +++ +L N + I+ A
Sbjct: 545 AGRYPLSDFTLLTEARRTLGLFQHHDAITGTAKEAVVVDYGVRLLRSLVNLKQVIIHAAH 604
Query: 1605 VVLLGIDSTNK-------MQMDEHRVNENLLPEKRVYKIGQN---VVLFNTLSRNRNEPI 1456
++LG T +Q+D+ R++ + LPE+ V ++ + VVLFN L + R +
Sbjct: 605 YLVLGDKETYHFDPEAPFLQVDDTRLSHDALPERTVIQLDSSPRFVVLFNPLEQERFSMV 664
Query: 1455 CIQVDSLDAGV--EADPPIKKQQVSPVIAYDEEKKTLVVKNGIFELCFMLSLGPMESVSF 1282
+ V+S V E P+ Q+S + E V + + L LG ++
Sbjct: 665 SLLVNSPRVRVLSEEGQPL-AVQISAHWSSATEAVPDVYQVSVPVRLPALGLGVLQLQLG 723
Query: 1281 RLVKNTTTSKVEIITNNAAXXXXXXXX-----XXXXSGDFTVKNDKVEAEFDGENGMIKR 1117
T S V I + + DF + N ++ F G G++K
Sbjct: 724 LDGHRTLPSSVRIYLHGRQLSVSRHEAFPLRVIDSGTSDFALSNRYMQVWFSGLTGLLKS 783
Query: 1116 ATSLVDDKPIDLNSHFIHYGARKSKRKFANGNEDNPAGAYLFLPDGEARELKKQSSDWIL 937
+ ++ ++ + YG R SK K +GAYLFLPDGEA +S +
Sbjct: 784 IRRVDEEHEQQVDMQVLVYGTRTSKDK---------SGAYLFLPDGEASPTSPRSPPCCV 834
Query: 936 VKGEVVQKVFATPNNDLKILQTYTLYQGL--------PWIDLDNEVDVRSKENFELALRF 781
+ + + + +T+ QG PW
Sbjct: 835 SLKALSSQRWLRTMSTFTRRSGFTICQGWRGCLWTYHPWWTSG----------------- 877
Query: 780 SSSVNSGDEFFTDLNGMQMIKRRRQTKLPTQANFYPMSAGVYIEDDTTRMSIHSAQALGV 601
++S S + ++ RR KLP QANFYPM YI+D R+++H+AQALGV
Sbjct: 878 TTSTRSWPCTSIQTSTARVQPRRYLKKLPLQANFYPMPVMAYIQDAQKRLTLHTAQALGV 937
Query: 600 SSLSSGQIEIMLDRRLSSDDNRGLQQGVRDNKRTVAHFRIVIEPMSSSSGNKKEERVGFH 421
SSL GQ+E++LDRRL DDNRGL QG++DNKRT FR+++E + S + +
Sbjct: 938 SSLKDGQLEVILDRRLMQDDNRGLGQGLKDNKRTCNRFRLLLERRTVGSEVQDSHSTSYP 997
Query: 420 SHVGHLATWSLHYPL----VKMIGDATPKSISSKNVEQELNCDLHLVTFRTLASPTTYEA 253
S + HL + L+ P V + P S + L CD HL+ RTL +
Sbjct: 998 SLLSHLTSMYLNAPALALPVARMQLPGPGLRSFHPLASSLPCDFHLLNLRTLQA------ 1051
Query: 252 NERSTAAEKKAAMVMHRVVPDCRSRLTLPDTSCLATGLEIEPLKLISTLKSAKKTSLTNL 73
E T + A+++HR DC GLE + L T S K +L +L
Sbjct: 1052 -EEDTLPSAETALILHRKGFDC--------------GLEAKNLGFNCT-TSQGKVALGSL 1095
Query: 72 YEGNKAEQFRLQPNDIS 22
+ G + LQP ++
Sbjct: 1096 FHG--LDVVFLQPTSLT 1110
>gi|50753420|ref|XP_413979.1| PREDICTED: similar to Alpha-mannosidase
II (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase)
(MAN II) (Golgi alpha-mannosidase II) (Mannosidase alpha
class 2A member 1) [Gallus gallus]
Length = 1216
Score = 643 bits (1659), Expect = 0.0
Identities = 360/937 (38%), Positives = 556/937 (58%), Gaps = 45/937 (4%)
Frame = -1
Query: 2859 GWIMTFEEYYNRQTRNILDGMAKHLAEKDEMRFIYAEISFFETWWRDQADEIKKKVKGYL 2680
GW+ TF++Y+ QT++IL+ M L E + +FI++EIS+F WW + + VK +
Sbjct: 248 GWLKTFDDYFRDQTQHILNNMVIKLQEDNRRKFIWSEISYFSKWWDGIDSQRRDAVKRLI 307
Query: 2679 EAGKFEIVTGGWVMTDEANAHYHSMITELFEGHEWIQNHLGKSAIPQSHWSIDPFGLSPS 2500
+ G+FEIVTGGWVM DEA+AHY S+I +L EGH+W++ +LG P+S W++DPFG SP+
Sbjct: 308 KDGQFEIVTGGWVMPDEASAHYFSLIDQLIEGHQWLERNLGVK--PKSGWAVDPFGHSPT 365
Query: 2499 MPHLLTSANITNAVIQRVHYSVKRELALKKNLEFYWRQLFGSTGHPDLRSHIMPFYSYDI 2320
M +LL A +N +IQR+HYSVK+ + +K LEF+WRQ + D+ H+MPFYSYD+
Sbjct: 366 MAYLLKRAGFSNMLIQRIHYSVKKYFSAQKTLEFFWRQNWDLGSSTDILCHMMPFYSYDV 425
Query: 2319 PHTCGPEPSVCCQFDFRRMPEGGKSCDWGIPPQKINDDNV------AHRAEMIYDQYRKK 2158
PHTCGP+P +CCQFDF+R+P G C + + + D++ A +A MI DQYRKK
Sbjct: 426 PHTCGPDPKICCQFDFKRLPGGRMVCLLPVEDLRDSRDSIVQYSATAVQAWMILDQYRKK 485
Query: 2157 SQLFKNNVIFQPLGDDFRYDIDFEWNSQYENYKKLFEYMNSKSEWNVHAQFGTLSDYFKK 1978
S+LF+ V+ PLGDDFRY EW+ QY+NY+KLF+YMN+ E++V AQFGTLSDYF+
Sbjct: 486 SKLFRTKVLLAPLGDDFRYAESSEWDQQYQNYQKLFDYMNTHPEFHVKAQFGTLSDYFEA 545
Query: 1977 L----DTAISASGEQLPTFSGDFFTYADRDDHYWSGYFTSRPFYKQLDRVLQHYLRSAEI 1810
L + +S P SGDFFTYADRD HYWSGYFTSRPFYK+LDRVL+ +LR+AEI
Sbjct: 546 LRKESNLGEGSSSPLFPVLSGDFFTYADRDHHYWSGYFTSRPFYKRLDRVLESHLRAAEI 605
Query: 1809 AFTLANIEEEGMVEAKIFE-----KLVT-ARRALSLFQHHDGVTGTAKDHVVLDYGQKMI 1648
++LA I+ + +F KL+T ARR L LFQHHD +TGT+KD VV+DYG ++
Sbjct: 606 LYSLALIQSHKYNKMSVFPSVDNYKLLTEARRNLGLFQHHDAITGTSKDWVVVDYGTRLF 665
Query: 1647 DALNACEDILSEALVVLLGID--------STNKMQMDEHRVNENLLPEKRVYKIGQN--- 1501
+L + ++ ++ +L+ D ST ++MD+ + +++ LP K V K+
Sbjct: 666 HSLMNVKKVIIDSAHILILKDKGAYNYDTSTPFLKMDDVQSSQDSLPHKTVIKLTSQPRY 725
Query: 1500 VVLFNTLSRNRNEPICIQVDSLDAGVEADPPIKKQQVSPVIAYDEEKKTLVVKNGIFELC 1321
+++ N + R + + V S V+ P+ K + A + T V + +++
Sbjct: 726 LLIHNPTDQERFSVVSVIVSS--PRVKLLSPLGKPVTVQISAVWDGATT--VSHEAYQVS 781
Query: 1320 FMLSLGPMESVSFRLVKNTTTSKVEIITNNAAXXXXXXXXXXX-----------XSGDFT 1174
F+ L P+ ++L++ +S+ + N +
Sbjct: 782 FLAHLPPLGLGVYQLLE-VPSSEANLAEYNIYMSGRDSVQEKSDRIFKIKEMQNSVDNII 840
Query: 1173 VKNDKVEAEFDGENGMIKRATSLVDDKPIDLNSHFIHYGARKSKRKFANGNEDNPAGAYL 994
++N ++ F G +G++++ + D K + F YG ++ K +GAYL
Sbjct: 841 LENSYMKLWFSGTSGLLEKINTKEDGKNHQMKVEFAWYGTTSNRDK---------SGAYL 891
Query: 993 FLPDGEARELKKQSSDWILVK-GEVVQKVFATPNNDLKILQTYTLYQGLPW--IDLDNEV 823
FLPDG+A+ + V G++ +V ++ ++ Y + QGL +++ N V
Sbjct: 892 FLPDGDAKPYIFTDPPTVRVAHGKIFSEVVCFFHHVTHTMRLYNV-QGLEGQSLEVSNIV 950
Query: 822 DVRSKENFELALRFSSSVNSGDEFFTDLNGMQMIKRRRQTKLPTQANFYPMSAGVYIEDD 643
D+R + N ELA+R SS +NS + F+ DLNG Q+ R +KLP QAN YPM+ YI+D
Sbjct: 951 DIRGEYNRELAMRISSDINSRNRFYVDLNGYQIQPRLTMSKLPLQANIYPMTTMAYIQDS 1010
Query: 642 TTRMSIHSAQALGVSSLSSGQIEIMLDRRLSSDDNRGLQQGVRDNKRTVAHFRIVIEPMS 463
R+++HSAQ+LGV+SL +GQ+E+++DRRL DDNRGL QGV+DNK T FR+++E
Sbjct: 1011 GVRLTLHSAQSLGVASLKNGQLEVIMDRRLMQDDNRGLGQGVQDNKITANVFRLLLERRH 1070
Query: 462 SSSGNKKEERVGFHSHVGHLATWSLHYPLVKMIGDA---TPKSISS-KNVEQELNCDLHL 295
+ N+++ V F S + H+ + L++P++ M +A P+ ++ + + CD+H+
Sbjct: 1071 GTDVNEEKASVSFPSLLSHMTSSFLNHPVIPMTTNADSGVPEMLNMFSPLMSSMPCDIHI 1130
Query: 294 VTFRTLASPTTYEANERSTAAEKKAAMVMHRVVPDCR 184
V RT+ S E ++ +AA+++HR DCR
Sbjct: 1131 VNLRTIQSKVDTEPSD-------EAALILHRKGFDCR 1160