Homology by BLASTX
BLASTX 2.2.4 [Aug-26-2002]
Query= R03D7_1
(3750 letters)
Database: /home/niguts/usr02/tshini/ykclst/db/nr.seq
1,967,186 sequences; 661,712,633 total letters
Score E
Sequences producing significant alignments: (bits) Value
gi|17535405|ref|NP_496353.1| 5-methyltetrahydrofolate-homocystei... 2453 0.0
gi|39591176|emb|CAE73229.1| Hypothetical protein CBG20636 [Caeno... 2330 0.0
gi|37620202|ref|NP_932338.1| 5-methyltetrahydrofolate-homocystei... 1607 0.0
gi|2842762|sp|Q99707|METH_HUMAN Methionine synthase (5-methyltet... 1603 0.0
gi|4557765|ref|NP_000245.1| 5-methyltetrahydrofolate-homocystein... 1603 0.0
gi|13540691|ref|NP_110491.1| methionine synthase [Rattus norvegi... 1582 0.0
gi|38074217|ref|XP_138431.3| 5-methyltetrahydrofolate-homocystei... 1490 0.0
gi|41407957|ref|NP_960793.1| MetH [Mycobacterium avium subsp. pa... 1291 0.0
gi|34495658|ref|NP_899873.1| probable 5-methyltetrahydrofolate-h... 1278 0.0
gi|39936764|ref|NP_949040.1| methionine synthase [Rhodopseudomon... 1277 0.0
gi|27376529|ref|NP_768058.1| methionine synthase [Bradyrhizobium... 1275 0.0
gi|21674670|ref|NP_662735.1| 5-methyltetrahydrofolate-homocystei... 1271 0.0
gi|15597040|ref|NP_250534.1| methionine synthase [Pseudomonas ae... 1271 0.0
gi|23105437|ref|ZP_00091893.1| COG1410: Methionine synthase I, c... 1271 0.0
gi|27364808|ref|NP_760336.1| Methionine synthase I [Vibrio vulni... 1270 0.0
gi|24217169|ref|NP_714652.1| B12-dependent homocysteine-N5-methy... 1270 0.0
gi|37681144|ref|NP_935753.1| cobalamin-dependent methionine synt... 1269 0.0
gi|17936039|ref|NP_532829.1| methionine synthase [Agrobacterium ... 1267 0.0
gi|15889436|ref|NP_355117.1| AGR_C_3907p [Agrobacterium tumefaci... 1267 0.0
gi|41176427|gb|AAR99583.1| 5-methyltetrahydrofolate-homocysteine... 1264 0.0
gi|28899491|ref|NP_799096.1| cobalamin-dependent methionine synt... 1262 0.0
gi|45914288|ref|ZP_00192660.2| COG1410: Methionine synthase I, c... 1257 0.0
gi|28869919|ref|NP_792538.1| 5-methyltetrahydrofolate--homocyste... 1256 0.0
gi|26989099|ref|NP_744524.1| 5-methyltetrahydrofolate--homocyste... 1255 0.0
gi|48863132|ref|ZP_00317026.1| COG1410: Methionine synthase I, c... 1254 0.0
gi|24372616|ref|NP_716658.1| 5-methyltetrahydrofolate--homocyste... 1251 0.0
gi|15966734|ref|NP_387087.1| PROBABLE 5-METHYLTETRAHYDROFOLATE--... 1250 0.0
gi|17988042|ref|NP_540676.1| 5-METHYLTETRAHYDROFOLATE--HOMOCYSTE... 1250 0.0
gi|23472268|ref|ZP_00127595.1| COG1410: Methionine synthase I, c... 1249 0.0
gi|23501099|ref|NP_697226.1| 5-methyltetrahydrofolate--homocyste... 1249 0.0
gi|16422743|gb|AAL23012.1| B12-dependent homocysteine-N5-methylt... 1248 0.0
gi|39546391|ref|NP_463053.2| B12-dependent homocysteine-N5-methy... 1248 0.0
gi|304910|gb|AAA02995.1| methionine synthase 1247 0.0
gi|16762890|ref|NP_458507.1| B12-dependent homocysteine-N5-methy... 1246 0.0
gi|16131845|ref|NP_418443.1| B12-dependent homocysteine-N5-methy... 1244 0.0
gi|409794|gb|AAC43113.1| B12-dependent homocysteine-N5-methyltet... 1244 0.0
gi|15804605|ref|NP_290646.1| B12-dependent homocysteine-N5-methy... 1244 0.0
gi|15640417|ref|NP_230044.1| 5-methyltetrahydrofolate--homocyste... 1243 0.0
gi|48733343|ref|ZP_00267086.1| COG1410: Methionine synthase I, c... 1242 0.0
gi|26250788|ref|NP_756828.1| 5-methyltetrahydrofolate--homocyste... 1242 0.0
gi|30064707|ref|NP_838878.1| B12-dependent homocysteine-N5-methy... 1239 0.0
gi|24115293|ref|NP_709803.1| B12-dependent homocysteine-N5-methy... 1239 0.0
gi|13540426|gb|AAK29461.1| MetH [Pseudomonas putida] 1238 0.0
gi|46914822|emb|CAG21599.1| putative cobalamin-dependent methion... 1231 0.0
gi|50122907|ref|YP_052074.1| 5-methyltetrahydrofolate--homocyste... 1229 0.0
gi|13366027|dbj|BAB39355.1| cobalamin-dependent methionine synth... 1228 0.0
gi|16123860|ref|NP_407173.1| 5-Methyltetrahydrofolate--homocyste... 1225 0.0
gi|33603430|ref|NP_890990.1| 5-methyltetrahydrofolate--homocyste... 1218 0.0
gi|33594462|ref|NP_882106.1| 5-methyltetrahydrofolate--homocyste... 1217 0.0
gi|33598486|ref|NP_886129.1| 5-methyltetrahydrofolate--homocyste... 1215 0.0
gi|30249588|ref|NP_841658.1| metH Methionine synthase I, cobalam... 1209 0.0
gi|581135|emb|CAA34601.1| unnamed protein product [Escherichia c... 1202 0.0
gi|50084246|ref|YP_045756.1| methionine synthase (B12-dependent ... 1197 0.0
gi|46141011|ref|ZP_00152801.2| COG1410: Methionine synthase I, c... 1196 0.0
gi|32476113|ref|NP_869107.1| 5-methyltetrahydrofolate--homocyste... 1189 0.0
gi|15805990|ref|NP_294690.1| 5-methyltetrahydrofolate--homocyste... 1179 0.0
gi|15893867|ref|NP_347216.1| Cobalamine-dependent methionine syn... 1165 0.0
gi|46141188|ref|ZP_00145376.2| COG1410: Methionine synthase I, c... 1157 0.0
gi|48833218|ref|ZP_00290240.1| COG1410: Methionine synthase I, c... 1156 0.0
gi|34365461|emb|CAE46059.1| hypothetical protein [Homo sapiens] 1021 0.0
gi|29345590|ref|NP_809093.1| 5-methyltetrahydrofolate-homocystei... 943 0.0
gi|48854978|ref|ZP_00309138.1| COG1410: Methionine synthase I, c... 929 0.0
gi|21242310|ref|NP_641892.1| 5-methyltetrahydrofolate-homocystei... 914 0.0
gi|46312303|ref|ZP_00212900.1| COG1410: Methionine synthase I, c... 910 0.0
gi|21230966|ref|NP_636883.1| 5-methyltetrahydrofolate-homocystei... 910 0.0
gi|46323648|ref|ZP_00224011.1| COG1410: Methionine synthase I, c... 909 0.0
gi|17545013|ref|NP_518415.1| PROBABLE 5-METHYLTETRAHYDROFOLATE--... 909 0.0
gi|48786383|ref|ZP_00282517.1| COG1410: Methionine synthase I, c... 906 0.0
gi|45515898|ref|ZP_00167452.1| COG1410: Methionine synthase I, c... 905 0.0
gi|22957858|ref|ZP_00005544.1| COG1410: Methionine synthase I, c... 894 0.0
gi|48770516|ref|ZP_00274859.1| COG1410: Methionine synthase I, c... 894 0.0
gi|47574009|ref|ZP_00244046.1| COG1410: Methionine synthase I, c... 880 0.0
gi|16126376|ref|NP_420940.1| 5-methyltetrahydrofolate--homocyste... 879 0.0
gi|48850561|ref|ZP_00304803.1| COG1410: Methionine synthase I, c... 815 0.0
gi|30022333|ref|NP_833964.1| 5-methyltetrahydrofolate--homocyste... 710 0.0
gi|42783378|ref|NP_980625.1| 5-methyltetrahydrofolate--homocyste... 702 0.0
gi|47567815|ref|ZP_00238523.1| 5-methyltetrahydrofolate--homocys... 698 0.0
gi|49478593|ref|YP_038314.1| 5-methyltetrahydrofolate--homocyste... 698 0.0
gi|21402300|ref|NP_658285.1| S-methyl_trans, Homocysteine S-meth... 696 0.0
gi|15614193|ref|NP_242496.1| 5-methyltetrahydrofolate S-homocyst... 693 0.0
gi|3122391|sp|O33465|METH_PSEPU Methionine synthase (5-methyltet... 670 0.0
gi|18158881|pdb|1K7Y|A Chain A, E. Coli Meth C-Terminal Fragment... 561 e-158
gi|22298571|ref|NP_681818.1| 5-methyltetrahydrofolate--homocyste... 555 e-156
gi|23126339|ref|ZP_00108238.1| COG0646: Methionine synthase I (c... 550 e-155
gi|29833209|ref|NP_827843.1| putative 5-methyltetrahydrofolate:h... 549 e-154
gi|30795021|ref|NP_851471.1| probable 5-methyltetrahydrofolate-h... 549 e-154
gi|21220153|ref|NP_625932.1| putative methionine synthase [Strep... 548 e-154
gi|17227804|ref|NP_484352.1| 5-methyltetrahydrofolate--homocyste... 548 e-154
gi|22971808|ref|ZP_00018731.1| hypothetical protein [Chloroflexu... 546 e-153
gi|16331640|ref|NP_442368.1| 5-methyltetrahydrofolate--homocyste... 545 e-153
gi|48891258|ref|ZP_00324810.1| COG1410: Methionine synthase I, c... 545 e-153
gi|45512893|ref|ZP_00164459.1| COG1410: Methionine synthase I, c... 544 e-153
gi|33865772|ref|NP_897331.1| putative methionine synthase [Synec... 540 e-152
gi|33240409|ref|NP_875351.1| 5-methyltetrahydrofolate--homocyste... 531 e-149
gi|48891299|ref|ZP_00324839.1| COG1410: Methionine synthase I, c... 525 e-147
gi|46198561|ref|YP_004228.1| 5-methyltetrahydrofolate-homocystei... 523 e-146
gi|38233847|ref|NP_939614.1| 5-methyltetrahydrofolate--homocyste... 523 e-146
gi|33863001|ref|NP_894561.1| putative methionine synthase [Proch... 521 e-146
gi|45506539|ref|ZP_00158892.1| COG1410: Methionine synthase I, c... 517 e-145
gi|25028193|ref|NP_738247.1| putative 5-methyltetrahydrofolate--... 516 e-144
gi|37520046|ref|NP_923423.1| 5-methyltetrahydrofolate--homocyste... 513 e-143
gi|33861434|ref|NP_892995.1| putative methionine synthase [Proch... 511 e-143
gi|48764671|ref|ZP_00269222.1| COG1410: Methionine synthase I, c... 511 e-143
gi|48837236|ref|ZP_00294231.1| COG1410: Methionine synthase I, c... 508 e-142
gi|31793304|ref|NP_855797.1| Probable 5-methyltetrahydrofolate--... 508 e-142
gi|15609261|ref|NP_216640.1| metH [Mycobacterium tuberculosis H3... 507 e-142
gi|19552721|ref|NP_600723.1| Methionine synthase I, cobalamin-bi... 506 e-141
gi|23014861|ref|ZP_00054657.1| COG1410: Methionine synthase I, c... 505 e-141
gi|41325726|emb|CAF21515.1| Homocysteine Methyltransferase [Cory... 504 e-141
gi|50745347|ref|XP_420073.1| PREDICTED: similar to methionine sy... 504 e-141
gi|15827677|ref|NP_301940.1| 5-methyltetrahydrofolate-homocystei... 491 e-137
gi|3915951|sp|Q57195|YA42_HAEIN Hypothetical protein HI1042 >gnl... 485 e-135
gi|4200262|emb|CAA22918.1| putative 5-methyltetrahydrofolate-hom... 485 e-135
gi|47210230|emb|CAF95217.1| unnamed protein product [Tetraodon n... 455 e-126
gi|47209125|emb|CAF94368.1| unnamed protein product [Tetraodon n... 447 e-124
gi|34557599|ref|NP_907414.1| S-METHYLTRANSFERASE [Wolinella succ... 447 e-124
gi|45526435|ref|ZP_00177640.1| COG1410: Methionine synthase I, c... 437 e-121
gi|2145915|pir||S72842 methionine synthase metH2 - Mycobacterium... 433 e-119
gi|45522014|ref|ZP_00173530.1| COG1410: Methionine synthase I, c... 428 e-118
gi|15841616|ref|NP_336653.1| 5-methyltetrahydrofolate-homocystei... 416 e-114
gi|20146075|emb|CAD29687.1| putative methionine synthase [Pseudo... 408 e-112
gi|26351897|dbj|BAC39585.1| unnamed protein product [Mus musculus] 407 e-111
gi|32041915|ref|ZP_00139498.1| COG1410: Methionine synthase I, c... 406 e-111
gi|23012828|ref|ZP_00052823.1| COG0646: Methionine synthase I (c... 403 e-110
gi|46133249|ref|ZP_00203109.1| COG1410: Methionine synthase I, c... 402 e-110
gi|46202659|ref|ZP_00052822.2| COG1410: Methionine synthase I, c... 394 e-107
gi|48854979|ref|ZP_00309139.1| COG0646: Methionine synthase I (c... 394 e-107
gi|79040|pir||PS0016 5-methyltetrahydrofolate-homocysteine S-met... 389 e-106
gi|23120271|ref|ZP_00103006.1| COG1410: Methionine synthase I, c... 373 e-101
gi|31195863|ref|XP_306879.1| ENSANGP00000016321 [Anopheles gambi... 370 e-100
gi|6681412|dbj|BAA88674.1| 5-methyltetrahydrofolate (homocystein... 370 e-100
gi|21242311|ref|NP_641893.1| 5-methyltetrahydrofolate-homocystei... 366 3e-99
gi|48786386|ref|ZP_00282520.1| COG0646: Methionine synthase I (c... 363 1e-98
gi|21230967|ref|NP_636884.1| 5-methyltetrahydrofolate-homocystei... 361 6e-98
gi|46323647|ref|ZP_00224010.1| COG0646: Methionine synthase I (c... 352 4e-95
gi|48847272|ref|ZP_00301529.1| COG1410: Methionine synthase I, c... 352 4e-95
gi|46312302|ref|ZP_00212899.1| COG0646: Methionine synthase I (c... 351 7e-95
gi|48770517|ref|ZP_00274860.1| COG0646: Methionine synthase I (c... 350 1e-94
gi|47574011|ref|ZP_00244048.1| COG0646: Methionine synthase I (c... 347 1e-93
gi|45515897|ref|ZP_00167451.1| COG0646: Methionine synthase I (c... 342 3e-92
gi|17545014|ref|NP_518416.1| PROBABLE 5-METHYLTETRAHYDROFOLATE--... 342 3e-92
gi|46193025|ref|ZP_00005543.2| COG0646: Methionine synthase I (c... 341 7e-92
gi|39998012|ref|NP_953963.1| 5-methyltetrahydrofolate-homocystei... 341 7e-92
gi|16126377|ref|NP_420941.1| 5-methyltetrahydrofolate--homocyste... 339 3e-91
gi|50877091|emb|CAG36931.1| related to 5-methyltetrahydrofolate-... 335 5e-90
gi|48850560|ref|ZP_00304802.1| COG0646: Methionine synthase I (c... 328 5e-88
gi|48858125|ref|ZP_00312090.1| COG1410: Methionine synthase I, c... 324 1e-86
gi|28211449|ref|NP_782393.1| 5-methyltetrahydrofolate--homocyste... 298 9e-79
gi|20808220|ref|NP_623391.1| Methionine synthase I, cobalamin-bi... 298 9e-79
gi|2098479|pdb|1MSK| Methionine Synthase (Activation Domain) 293 2e-77
gi|46579996|ref|YP_010804.1| vitamin B12-dependent methionine sy... 293 3e-77
gi|23474643|ref|ZP_00129936.1| COG1410: Methionine synthase I, c... 291 6e-77
gi|15643038|ref|NP_228081.1| 5-methyltetrahydrofolate S-homocyst... 290 1e-76
gi|13646894|dbj|BAB41103.1| methionine synthase [Pseudomonas psy... 290 2e-76
gi|1065138|pdb|1BMT|A Chain A, Methionine Synthase (B12-Binding ... 283 3e-74
gi|50767952|ref|XP_423046.1| PREDICTED: similar to methionine sy... 268 1e-69
gi|50762677|ref|XP_422875.1| PREDICTED: similar to Methionine sy... 267 1e-69
gi|23004089|ref|ZP_00047601.1| COG1410: Methionine synthase I, c... 256 4e-66
gi|19703508|ref|NP_603070.1| 5-methyltetrahydrofolate--homocyste... 232 6e-59
gi|50740996|ref|XP_426141.1| PREDICTED: similar to methionine sy... 231 1e-58
gi|34762564|ref|ZP_00143560.1| 5-methyltetrahydrofolate--homocys... 229 3e-58
gi|50770068|ref|XP_423104.1| PREDICTED: similar to methionine sy... 221 1e-55
gi|8571482|gb|AAF76901.1| methionine synthase [Sus scrofa] 210 2e-52
gi|23118676|ref|ZP_00102100.1| COG1410: Methionine synthase I, c... 207 2e-51
gi|47168618|pdb|1Q7M|A Chain A, Cobalamin-Dependent Methionine S... 204 1e-50
gi|47168624|pdb|1Q85|A Chain A, Cobalamin-Dependent Methionine S... 199 4e-49
gi|29345659|ref|NP_809162.1| 5-methyltetrahydrofolate--homocyste... 188 7e-46
gi|22530892|gb|AAM96905.1| methionine synthase [Bos taurus] 186 4e-45
gi|50877090|emb|CAG36930.1| related to 5-methyltetrahydrofolate-... 158 8e-37
gi|50764173|ref|XP_422936.1| PREDICTED: similar to Methionine sy... 157 2e-36
gi|15614192|ref|NP_242495.1| BH1629~unknown conserved protein [B... 141 1e-31
gi|39998065|ref|NP_954016.1| methylenetetrahydrofolate reductase... 137 2e-30
gi|23111920|ref|ZP_00097479.1| COG0646: Methionine synthase I (c... 136 4e-30
gi|45546712|ref|ZP_00186784.1| COG0646: Methionine synthase I (c... 133 3e-29
gi|30022334|ref|NP_833965.1| 5-methyltetrahydrofolate--homocyste... 131 1e-28
gi|30264327|ref|NP_846704.1| homocysteine S-methyltransferase do... 131 1e-28
gi|47567816|ref|ZP_00238524.1| 5-methyltetrahydrofolate--homocys... 131 1e-28
gi|46192730|ref|ZP_00006179.2| COG0646: Methionine synthase I (c... 130 2e-28
gi|13471290|ref|NP_102859.1| 5-methyltetrahydrofolate S-homocyst... 129 4e-28
gi|42783379|ref|NP_980626.1| homocysteine S-methyltransferase do... 129 7e-28
gi|21402301|ref|NP_658286.1| S-methyl_trans, Homocysteine S-meth... 128 9e-28
gi|16800854|ref|NP_471122.1| similar to 5-methyltetrahydrofolate... 127 3e-27
gi|47096751|ref|ZP_00234335.1| homocysteine S-methyltransferase ... 124 1e-26
gi|16803718|ref|NP_465203.1| similar to 5-methyltetrahydrofolate... 124 1e-26
gi|48847227|ref|ZP_00301484.1| COG0685: 5,10-methylenetetrahydro... 124 1e-26
gi|15965724|ref|NP_386077.1| CONSERVED HYPOTHETICAL PROTEIN [Sin... 118 1e-24
gi|24379328|ref|NP_721283.1| conserved hypothetical protein; put... 118 1e-24
gi|16078165|ref|NP_388982.1| yitJ [Bacillus subtilis subsp. subt... 117 3e-24
gi|5257177|gb|AAD41251.1| MetH [Pseudomonas putida] >gnl|BL_ORD_... 116 5e-24
gi|27469299|ref|NP_765936.1| conserved hypothetical protein [Sta... 114 2e-23
gi|15923347|ref|NP_370881.1| conserved hypothetical protein [Sta... 110 3e-22
gi|49482587|ref|YP_039811.1| conserved hypothetical protein [Sta... 109 6e-22
gi|28378112|ref|NP_785004.1| 5-methyltetrahydrofolate--homocyste... 108 1e-21
gi|21282062|ref|NP_645150.1| conserved hypothetical protein [Sta... 107 2e-21
gi|22538183|ref|NP_689034.1| 5-methyltetrahydrofolate--homocyste... 106 5e-21
gi|13475185|ref|NP_106749.1| similar to 5-methyltetrahydrofolate... 105 6e-21
gi|46192731|ref|ZP_00006181.2| COG5012: Predicted cobalamin bind... 104 1e-20
gi|23114550|ref|ZP_00099846.1| COG5012: Predicted cobalamin bind... 103 3e-20
gi|15965730|ref|NP_386083.1| PUTATIVE DIMETHYLAMINE CORRINOID PR... 102 7e-20
gi|37181246|gb|AAQ89565.1| veratrol O-demethylase corrinoid prot... 101 1e-19
gi|23114553|ref|ZP_00099849.1| COG5012: Predicted cobalamin bind... 101 1e-19
gi|23111631|ref|ZP_00097239.1| COG5012: Predicted cobalamin bind... 101 2e-19
gi|13471298|ref|NP_102867.1| corrinoid methyltransferase protein... 101 2e-19
gi|49235084|ref|ZP_00329159.1| COG5012: Predicted cobalamin bind... 100 3e-19
gi|49235445|ref|ZP_00329514.1| COG5012: Predicted cobalamin bind... 100 3e-19
gi|22001751|sp|Q8TS71|MBC2_METAC Dimethylamine corrinoid protein 2 100 5e-19
gi|20089812|ref|NP_615887.1| dimethylamine corrinoid protein [Me... 100 5e-19
gi|23112948|ref|ZP_00098369.1| COG5012: Predicted cobalamin bind... 99 8e-19
gi|29345750|ref|NP_809253.1| trimethylamine corrinoid protein 2 ... 99 8e-19
gi|11497627|ref|NP_068847.1| corrinoid methyltransferase protein... 99 1e-18
gi|15893583|ref|NP_346932.1| FUSION: methionine sintase I (cobal... 99 1e-18
gi|42630146|ref|ZP_00155690.1| COG1410: Methionine synthase I, c... 98 1e-18
gi|11497632|ref|NP_068852.1| corrinoid methyltransferase protein... 98 2e-18
gi|22095825|sp|P58979|MBC1_METMA Dimethylamine corrinoid protein 1 97 3e-18
gi|21228154|ref|NP_634076.1| dimethylamine corrinoid protein [Me... 97 3e-18
gi|49236438|ref|ZP_00330497.1| COG1410: Methionine synthase I, c... 97 4e-18
gi|20089418|ref|NP_615493.1| trimethylamine corrinoid protein [M... 96 5e-18
gi|48840313|ref|ZP_00297240.1| COG5012: Predicted cobalamin bind... 96 5e-18
gi|22001820|sp|O93659|MTTC_METBA Trimethylamine corrinoid protei... 96 7e-18
gi|20089416|ref|NP_615491.1| dimethylamine corrinoid protein [Me... 96 7e-18
gi|21227792|ref|NP_633714.1| dimethylamine corrinoid protein [Me... 96 9e-18
gi|20089809|ref|NP_615884.1| trimethylamine corrinoid protein [M... 96 9e-18
gi|21228149|ref|NP_634071.1| dimethylamine corrinoid protein [Me... 95 1e-17
gi|20092957|ref|NP_619032.1| corrinoid protein [Methanosarcina a... 95 1e-17
gi|22095826|sp|P58980|MBC2_METMA Dimethylamine corrinoid protein 2 94 2e-17
gi|21229063|ref|NP_634985.1| dimethylamine corrinoid protein [Me... 94 2e-17
gi|15965739|ref|NP_386092.1| PUTATIVE METHYLTRANSFERASE PROTEIN ... 94 2e-17
gi|48838259|ref|ZP_00295205.1| COG5012: Predicted cobalamin bind... 94 2e-17
gi|38147028|gb|AAC83695.2| vanillate specific O-demethylase corr... 93 4e-17
gi|23115042|ref|ZP_00100317.1| COG5012: Predicted cobalamin bind... 93 6e-17
gi|23114704|ref|ZP_00099991.1| COG5012: Predicted cobalamin bind... 93 6e-17
gi|42630142|ref|ZP_00155686.1| COG1410: Methionine synthase I, c... 92 9e-17
gi|20089743|ref|NP_615818.1| hypothetical protein (multi-domain)... 92 9e-17
gi|49236437|ref|ZP_00330496.1| COG5012: Predicted cobalamin bind... 92 1e-16
gi|22001818|sp|O93657|MTBC_METBA Dimethylamine corrinoid protein... 91 2e-16
gi|20093342|ref|NP_619417.1| hypothetical protein (multi-domain)... 91 2e-16
gi|48838296|ref|ZP_00295242.1| COG5012: Predicted cobalamin bind... 91 3e-16
gi|49235916|ref|ZP_00329980.1| COG5012: Predicted cobalamin bind... 91 3e-16
gi|22956596|ref|ZP_00004349.1| COG1410: Methionine synthase I, c... 91 3e-16
gi|20091255|ref|NP_617330.1| dimethylamine corrinoid protein [Me... 91 3e-16
gi|18310399|ref|NP_562333.1| hypothetical protein CPE1417 [Clost... 90 4e-16
gi|23112351|ref|ZP_00097845.1| COG5012: Predicted cobalamin bind... 90 4e-16
gi|49235441|ref|ZP_00329510.1| COG5012: Predicted cobalamin bind... 90 4e-16
gi|48840310|ref|ZP_00297237.1| COG5012: Predicted cobalamin bind... 89 6e-16
gi|23112251|ref|ZP_00097758.1| COG5012: Predicted cobalamin bind... 89 6e-16
gi|41719888|ref|ZP_00148749.1| COG5012: Predicted cobalamin bind... 88 2e-15
gi|41719990|ref|ZP_00148829.1| COG5012: Predicted cobalamin bind... 88 2e-15
gi|49235917|ref|ZP_00329981.1| COG1410: Methionine synthase I, c... 87 2e-15
gi|23112839|ref|ZP_00098272.1| COG5012: Predicted cobalamin bind... 87 3e-15
gi|21542124|sp|O30641|MMC1_METBA Monomethylamine corrinoid prote... 87 3e-15
gi|41719890|ref|ZP_00148751.1| COG5012: Predicted cobalamin bind... 87 4e-15
gi|48840654|ref|ZP_00297580.1| COG5012: Predicted cobalamin bind... 86 5e-15
gi|48841191|ref|ZP_00298117.1| COG5012: Predicted cobalamin bind... 86 5e-15
gi|20091789|ref|NP_617864.1| monomethylamine corrinoid protein [... 86 7e-15
gi|48840651|ref|ZP_00297577.1| COG5012: Predicted cobalamin bind... 86 9e-15
gi|23114625|ref|ZP_00099917.1| COG5012: Predicted cobalamin bind... 86 9e-15
gi|13471306|ref|NP_102875.1| 5-methyltetrahydrofolate S-homocyst... 85 1e-14
gi|20093171|ref|NP_619246.1| hypothetical protein (multi-domain)... 85 1e-14
gi|45358714|ref|NP_988271.1| Coenzyme B12-binding:Cobalamin-depe... 85 1e-14
gi|48839663|ref|ZP_00296593.1| COG5012: Predicted cobalamin bind... 85 2e-14
gi|20089347|ref|NP_615422.1| methanol-5-hydroxybenzimidazolylcob... 84 3e-14
gi|21227750|ref|NP_633672.1| Methanol corrinoid protein MtaC [Me... 83 4e-14
gi|21227540|ref|NP_633462.1| Monomethylamine corrinoid protein [... 83 6e-14
gi|15230929|ref|NP_189219.1| homocysteine S-methyltransferase 1 ... 83 6e-14
gi|21229436|ref|NP_635358.1| Monomethylamine corrinoid protein [... 83 6e-14
gi|22095879|sp|P58977|MMC1_METMA Monomethylamine corrinoid prote... 83 6e-14
gi|20089043|ref|NP_615118.1| monomethylamine corrinoid protein [... 83 6e-14
gi|23114428|ref|ZP_00099731.1| COG5012: Predicted cobalamin bind... 82 7e-14
gi|19421907|gb|AAL87795.1| unknown [Desulfitobacterium hafniense] 82 7e-14
gi|48840762|ref|ZP_00297688.1| COG5012: Predicted cobalamin bind... 82 7e-14
gi|23113654|ref|ZP_00099013.1| COG1410: Methionine synthase I, c... 82 1e-13
gi|21227789|ref|NP_633711.1| dimethylamine corrinoid protein [Me... 82 1e-13
gi|49236439|ref|ZP_00330498.1| COG2972: Predicted signal transdu... 82 1e-13
gi|23113982|ref|ZP_00099311.1| COG5012: Predicted cobalamin bind... 82 1e-13
gi|21227175|ref|NP_633097.1| Methanol corrinoid protein [Methano... 81 2e-13
gi|49236051|ref|ZP_00330113.1| COG0407: Uroporphyrinogen-III dec... 80 3e-13
gi|37181251|gb|AAQ89569.1| putative O-demethylase corrinoid prot... 80 3e-13
gi|12667197|gb|AAK01347.1| methyltransferase/corrinoid CmuA [Hyp... 80 4e-13
gi|21542140|sp|Q9P9L5|MMC2_METBA Monomethylamine corrinoid prote... 80 4e-13
gi|46133250|ref|ZP_00203110.1| COG1410: Methionine synthase I, c... 80 5e-13
gi|21226276|ref|NP_632198.1| Methanol corrinoid protein [Methano... 80 5e-13
gi|45358392|ref|NP_987949.1| Coenzyme B12-binding:Cobalamin-depe... 79 8e-13
gi|15896591|ref|NP_349940.1| Possible homocysteine S-methyltrans... 79 8e-13
gi|23113238|ref|ZP_00098632.1| COG5012: Predicted cobalamin bind... 79 1e-12
gi|23113989|ref|ZP_00099318.1| COG5012: Predicted cobalamin bind... 79 1e-12
gi|20093178|ref|NP_619253.1| methanol-5-hydroxybenzimidazolylcob... 78 1e-12
gi|23114312|ref|ZP_00099623.1| COG5012: Predicted cobalamin bind... 77 2e-12
gi|47187813|emb|CAF92494.1| unnamed protein product [Tetraodon n... 77 2e-12
gi|22255848|gb|AAM94773.1| CalE2 [Micromonospora echinospora] 77 2e-12
gi|20090475|ref|NP_616550.1| methanol-5-hydroxybenzimidazolylcob... 77 2e-12
gi|11352872|pir||T51708 methyltransferase (EC 2.1.1.-) cmuA [val... 77 3e-12
gi|23113323|ref|ZP_00098709.1| COG5012: Predicted cobalamin bind... 77 4e-12
gi|13475184|ref|NP_106748.1| similar to 5-methyltetrahydrofolate... 76 5e-12
gi|48838659|ref|ZP_00295600.1| COG5012: Predicted cobalamin bind... 76 5e-12
gi|48859878|ref|ZP_00313807.1| COG5012: Predicted cobalamin bind... 76 7e-12
gi|1019941|gb|AAC46231.1| methylthiol:coenzyme M methyltransfera... 76 7e-12
gi|23112252|ref|ZP_00097759.1| COG1410: Methionine synthase I, c... 75 9e-12
gi|32479635|emb|CAE02688.1| putative corrinoid protein [Methanoc... 75 1e-11
gi|33943591|gb|AAQ55470.1| putative 5-methyltetrahydrofolate--ho... 75 1e-11
gi|49235448|ref|ZP_00329517.1| COG1410: Methionine synthase I, c... 75 1e-11
gi|45533083|ref|ZP_00184077.1| COG2040: Homocysteine/selenocyste... 75 2e-11
gi|49235087|ref|ZP_00329162.1| COG1410: Methionine synthase I, c... 75 2e-11
gi|23112952|ref|ZP_00098373.1| COG5012: Predicted cobalamin bind... 74 2e-11
gi|49235918|ref|ZP_00329982.1| COG5012: Predicted cobalamin bind... 74 2e-11
gi|21228530|ref|NP_634452.1| Methylthiol:coenzyme M methyltransf... 74 3e-11
gi|37515370|emb|CAE48302.1| corrinoid protein [Methanosphaera st... 74 3e-11
gi|29828653|ref|NP_823287.1| putative homocysteine S-methyltrans... 73 5e-11
gi|13471338|ref|NP_102907.1| hypothetical protein mlr1281 [Mesor... 72 8e-11
gi|23114549|ref|ZP_00099845.1| COG1410: Methionine synthase I, c... 72 1e-10
gi|23111344|ref|ZP_00097017.1| COG5012: Predicted cobalamin bind... 71 2e-10
gi|45360513|ref|NP_988891.1| hypothetical protein MGC75760 [Xeno... 71 2e-10
gi|25011419|ref|NP_735814.1| unknown [Streptococcus agalactiae N... 71 2e-10
gi|22537452|ref|NP_688303.1| homocysteine S-methyltransferase Mm... 70 3e-10
gi|18403505|ref|NP_566715.1| homocysteine S-methyltransferase 3 ... 69 7e-10
gi|41719967|ref|ZP_00148806.1| COG5012: Predicted cobalamin bind... 69 9e-10
gi|23115041|ref|ZP_00100316.1| COG1410: Methionine synthase I, c... 69 9e-10
gi|50400645|sp|Q9FUN0|HMT1_MAIZE Homocysteine S-methyltransferas... 69 1e-09
gi|23113545|ref|ZP_00098912.1| COG5012: Predicted cobalamin bind... 69 1e-09
gi|23113253|ref|ZP_00098645.1| COG1410: Methionine synthase I, c... 68 2e-09
gi|15609595|ref|NP_216974.1| hypothetical protein Rv2458 [Mycoba... 67 2e-09
gi|23114703|ref|ZP_00099990.1| COG1410: Methionine synthase I, c... 67 3e-09
gi|32141288|ref|NP_733689.1| putative transferase [Streptomyces ... 67 4e-09
gi|46433218|gb|EAK92666.1| hypothetical protein CaO19.386 [Candi... 67 4e-09
gi|22748320|gb|AAN05322.1| Putative homocysteine S-methyltransfe... 67 4e-09
gi|12667211|gb|AAK01355.1| chloromethane utilization protein Cmu... 66 7e-09
gi|12667209|gb|AAK01354.1| chloromethane utilization protein Cmu... 66 7e-09
gi|31793639|ref|NP_856132.1| PROBABLE HOMOCYSTEINE S-METHYLTRANS... 65 9e-09
gi|22995698|ref|ZP_00040070.1| COG1410: Methionine synthase I, c... 65 9e-09
gi|21593147|gb|AAM65096.1| putative selenocysteine methyltransfe... 65 2e-08
gi|12667213|gb|AAK01356.1| chloromethane utilization protein Cmu... 65 2e-08
gi|13752775|gb|AAK01357.2| methyltransferase/corrinoid CmuA [Ami... 65 2e-08
gi|50405455|ref|XP_456363.1| unnamed protein product [Debaryomyc... 64 2e-08
gi|6094303|sp|P56707|SMTA_ASTBI Selenocysteine methyltransferase... 64 2e-08
gi|23112838|ref|ZP_00098271.1| COG1410: Methionine synthase I, c... 64 2e-08
gi|15841982|ref|NP_337019.1| homocysteine S-methyltransferase [M... 64 3e-08
gi|28378054|ref|NP_784946.1| homocysteine S-methyltransferase [L... 64 3e-08
gi|49235927|ref|ZP_00329991.1| COG1410: Methionine synthase I, c... 64 3e-08
gi|24379395|ref|NP_721350.1| putative methyltransferase [Strepto... 64 4e-08
gi|15889636|ref|NP_355317.1| AGR_C_4290p [Agrobacterium tumefaci... 63 6e-08
gi|22973034|ref|ZP_00019880.1| hypothetical protein [Chloroflexu... 62 8e-08
gi|23111696|ref|ZP_00097293.1| COG1410: Methionine synthase I, c... 62 1e-07
gi|15229396|ref|NP_191884.1| homocysteine S-methyltransferase 2 ... 62 1e-07
gi|50400643|sp|Q9FUM8|HMT3_MAIZE Homocysteine S-methyltransferas... 62 1e-07
gi|25453566|pir||T51939 homocysteine S-methyltransferase (EC 2.1... 61 2e-07
gi|21230801|ref|NP_636718.1| homocysteine S-methyltransferase [X... 60 3e-07
gi|2127371|pir||I40795 5-methyltetrahydrofolate corrinoid/iron s... 60 3e-07
gi|23113979|ref|ZP_00099308.1| COG1410: Methionine synthase I, c... 60 4e-07
gi|50400644|sp|Q9FUM9|HMT2_MAIZE Homocysteine S-methyltransferas... 60 4e-07
gi|23114135|ref|ZP_00099455.1| COG1410: Methionine synthase I, c... 60 4e-07
gi|50556936|ref|XP_505876.1| hypothetical protein [Yarrowia lipo... 60 5e-07
gi|16077310|ref|NP_388123.1| ybgG [Bacillus subtilis subsp. subt... 59 7e-07
gi|15827776|ref|NP_302039.1| possible transferase [Mycobacterium... 59 1e-06
gi|23117178|ref|ZP_00101360.1| COG5012: Predicted cobalamin bind... 58 2e-06
gi|42572531|ref|NP_974361.1| homocysteine S-methyltransferase 1 ... 58 2e-06
gi|21242145|ref|NP_641727.1| homocysteine S-methyltransferase [X... 58 2e-06
gi|48839194|ref|ZP_00296128.1| COG5012: Predicted cobalamin bind... 57 3e-06
gi|39997482|ref|NP_953433.1| B12-binding domain [Geobacter sulfu... 57 3e-06
gi|36958847|gb|AAQ87272.1| homocysteine S-methyltransferase (S-m... 57 3e-06
gi|16128246|ref|NP_414795.1| S-methylmethionine:homocysteine met... 57 4e-06
gi|41408377|ref|NP_961213.1| hypothetical protein MAP2279 [Mycob... 57 4e-06
gi|50121721|ref|YP_050888.1| homocysteine S-methyltransferase [E... 56 6e-06
gi|46188268|ref|ZP_00125487.2| COG2040: Homocysteine/selenocyste... 56 6e-06
gi|50400642|sp|Q9FUM7|HMT4_MAIZE Homocysteine S-methyltransferas... 56 7e-06
gi|21227157|ref|NP_633079.1| trimethylamine corrinoid protein [M... 56 7e-06
gi|37534456|ref|NP_921530.1| putative homocysteine S-methyltrans... 56 7e-06
gi|20093151|ref|NP_619226.1| corrinoid protein [Methanosarcina a... 55 2e-05
gi|23114430|ref|ZP_00099733.1| COG1410: Methionine synthase I, c... 55 2e-05
gi|19421909|gb|AAL87797.1| unknown [Desulfitobacterium hafniense] 55 2e-05
gi|4902995|dbj|BAA77929.1| Hypothetical protein YLL062c [Escheri... 54 2e-05
gi|28868350|ref|NP_790969.1| homocysteine S-methyltransferase fa... 54 3e-05
gi|31207005|ref|XP_312469.1| ENSANGP00000021355 [Anopheles gambi... 54 4e-05
gi|20150114|pdb|1I9C|A Chain A, Glutamate Mutase From Clostridiu... 54 4e-05
gi|42572773|ref|NP_974482.1| homocysteine S-methyltransferase 2 ... 53 5e-05
gi|26989495|ref|NP_744920.1| homocysteine S-methyltransferase fa... 52 1e-04
gi|48731374|ref|ZP_00265119.1| COG2040: Homocysteine/selenocyste... 52 1e-04
gi|17865765|sp|P80078|MAMA_CLOCO Methylaspartate mutase S chain ... 51 2e-04
gi|24158890|pdb|1LT7|A Chain A, Oxidized Homo Sapiens Betaine-Ho... 51 2e-04
gi|41719923|ref|ZP_00148784.1| COG5012: Predicted cobalamin bind... 51 2e-04
gi|23005680|ref|ZP_00048376.1| COG1410: Methionine synthase I, c... 50 3e-04
gi|24585077|ref|NP_609921.1| CG10623-PA [Drosophila melanogaster... 50 3e-04
gi|28212144|ref|NP_783088.1| glutamate mutase, mutS [Clostridium... 50 4e-04
gi|46129056|ref|ZP_00201983.1| COG1410: Methionine synthase I, c... 50 4e-04
gi|7245512|pdb|1CCW|A Chain A, Structure Of The Coenzyme B12 Dep... 50 4e-04
gi|13540663|ref|NP_110477.1| betaine-homocysteine methyltransfer... 50 5e-04
gi|7709990|ref|NP_057877.1| betaine-homocysteine methyltransfera... 50 5e-04
gi|49259376|pdb|1UMY|A Chain A, Bhmt From Rat Liver >gnl|BL_ORD_... 50 5e-04
gi|15922422|ref|NP_378091.1| 140aa long hypothetical methylmalon... 50 5e-04
gi|23113322|ref|ZP_00098708.1| COG1410: Methionine synthase I, c... 50 5e-04
gi|15899035|ref|NP_343640.1| Methylmalonyl-CoA mutase, alpha-sub... 49 0.001
gi|37181245|gb|AAQ89564.1| putative methyl corrinoid protein; MT... 49 0.001
gi|37181250|gb|AAQ89568.1| putative methyl corrinoid protein; MT... 49 0.001
gi|729588|sp|Q05488|MAMA_CLOTT Methylaspartate mutase S chain (G... 48 0.002
gi|26987394|ref|NP_742819.1| homocysteine S-methyltransferase fa... 48 0.002
gi|23114626|ref|ZP_00099918.1| COG1410: Methionine synthase I, c... 48 0.002
gi|39580621|emb|CAE69436.1| Hypothetical protein CBG15622 [Caeno... 47 0.003
gi|38018224|gb|AAR08188.1| betaine-homocysteine S-methyltransfer... 47 0.005
gi|4530461|gb|AAD22043.1| betaine-homocysteine methyltransferase... 47 0.005
gi|4502407|ref|NP_001704.1| betaine-homocysteine methyltransfera... 47 0.005
gi|48844515|ref|ZP_00298822.1| COG1410: Methionine synthase I, c... 46 0.006
gi|15830018|ref|NP_308791.1| putative glutamate mutase S [Escher... 46 0.008
gi|15800444|ref|NP_286456.1| putative glutamate mutase subumit S... 46 0.008
gi|50255720|gb|EAL18452.1| hypothetical protein CNBJ0940 [Crypto... 46 0.008
gi|7481583|pir||T35920 probable transferase - Streptomyces coeli... 46 0.008
gi|46202454|ref|ZP_00208522.1| COG2185: Methylmalonyl-CoA mutase... 46 0.008
gi|47227619|emb|CAG09616.1| unnamed protein product [Tetraodon n... 45 0.010
gi|42526533|ref|NP_971631.1| methylaspartate mutase, S subunit [... 45 0.013
gi|23112501|ref|ZP_00097976.1| COG2185: Methylmalonyl-CoA mutase... 44 0.022
gi|24217135|ref|NP_714618.1| methylmalonyl-CoA mutase [Leptospir... 43 0.050
gi|6322966|ref|NP_013038.1| S-Methylmethionine Homocysteine meth... 43 0.065
gi|50755288|ref|XP_414685.1| PREDICTED: similar to betaine homoc... 43 0.065
gi|26006819|sp|Q59268|MGM_EUBBA 2-methyleneglutarate mutase (Alp... 42 0.085
gi|48860187|ref|ZP_00314113.1| COG0294: Dihydropteroate synthase... 42 0.085
gi|6324982|ref|NP_015050.1| AdoMet-homocysteine methyltransferas... 42 0.11
gi|20807690|ref|NP_622861.1| Methylmalonyl-CoA mutase, C-termina... 42 0.11
gi|46192008|ref|ZP_00007571.2| COG1884: Methylmalonyl-CoA mutase... 42 0.15
gi|47218900|emb|CAG05666.1| unnamed protein product [Tetraodon n... 41 0.19
gi|48848413|ref|ZP_00302659.1| COG2040: Homocysteine/selenocyste... 41 0.19
gi|4206713|gb|AAD11782.1| c-13 antigen [Plasmodium falciparum] 41 0.19
gi|13162290|ref|NP_060084.2| betaine-homocysteine methyltransfer... 40 0.32
gi|48844612|ref|ZP_00298915.1| COG1884: Methylmalonyl-CoA mutase... 40 0.55
gi|46198984|ref|YP_004651.1| methylmalonyl-CoA mutase small subu... 40 0.55
gi|37675741|ref|NP_936137.1| 2-methylthioadenine synthetase [Vib... 40 0.55
gi|27367631|ref|NP_763158.1| 2-methylthioadenine synthetase [Vib... 40 0.55
gi|48870959|ref|ZP_00323676.1| COG0474: Cation transport ATPase ... 39 0.72
gi|26991314|ref|NP_746739.1| transcriptional regulator, MerR fam... 39 0.72
gi|38147030|gb|AAR11880.1| methyl corrinoid protein; MTIIvan [Ac... 39 0.72
gi|7206819|gb|AAF39978.1| Receptor mediated endocytosis protein ... 38 1.6
gi|18250262|gb|AAL65796.1| Receptor mediated endocytosis protein... 38 1.6
gi|31211357|ref|XP_314648.1| ENSANGP00000020769 [Anopheles gambi... 38 1.6
gi|17565132|ref|NP_504591.1| receptor Mediated Endocytosis RME-1... 38 1.6
gi|32566167|ref|NP_504592.2| receptor Mediated Endocytosis RME-1... 38 1.6
gi|39594267|emb|CAE71845.1| Hypothetical protein CBG18887 [Caeno... 38 1.6
gi|50306329|ref|XP_453138.1| unnamed protein product [Kluyveromy... 38 1.6
gi|50084595|ref|YP_046105.1| putative homocysteine S-methyltrans... 38 1.6
gi|27885035|gb|AAO25981.1| Receptor mediated endocytosis protein... 38 1.6
gi|17565130|ref|NP_504590.1| receptor Mediated Endocytosis RME-1... 38 1.6
gi|15807026|ref|NP_295755.1| methylmalonyl-CoA mutase, alpha sub... 38 2.1
gi|25148680|ref|NP_500276.2| one of two C. elegans orthologs of ... 38 2.1
gi|2120396|pir||S68197 regulatory protein 10 - Myxococcus xanthu... 38 2.1
gi|31746580|gb|AAP68914.1| L1 cam adhesion molecule homolog prot... 38 2.1
gi|15791096|ref|NP_280920.1| methylaspartate mutase; MamA [Halob... 38 2.1
gi|33240563|ref|NP_875505.1| Predicted protein kinase [Prochloro... 38 2.1
gi|17223685|gb|AAK72502.1| D-ornithine aminomutase E component [... 38 2.1
gi|12667195|gb|AAK01345.1| methyltransferase CmuB [Hyphomicrobiu... 37 2.7
gi|23114210|ref|ZP_00099526.1| COG2185: Methylmalonyl-CoA mutase... 37 2.7
gi|14520468|ref|NP_125943.1| methylmalonyl-CoA mutase, subunit a... 37 2.7
gi|14590199|ref|NP_142264.1| methylmalony-CoA mutase [Pyrococcus... 37 2.7
gi|18978318|ref|NP_579675.1| methylmalonyl-CoAmutase, subunit al... 37 3.6
gi|7481580|pir||T34650 probable transferase - Streptomyces coeli... 37 4.7
gi|25044789|gb|AAK93832.1| mucoepidermoid susceptibility protein... 37 4.7
gi|23612314|ref|NP_703894.1| ATP-dependent DEAD box helicase, pu... 37 4.7
gi|17557474|ref|NP_503969.1| predicted CDS, acyltransferase 3 fa... 36 6.1
gi|13430882|ref|NP_079297.1| mucoepidermoid carcinoma translocat... 36 6.1
gi|15234728|ref|NP_193944.1| protein kinase family protein [Arab... 36 8.0
gi|127550|sp|P11653|MUTB_PROFR Methylmalonyl-CoA mutase large su... 36 8.0
gi|7546641|pdb|5REQ|A Chain A, Methylmalonyl-Coa Mutase, Y89f Mu... 36 8.0
gi|8569647|pdb|1E1C|A Chain A, Methylmalonyl-Coa Mutase H244a Mu... 36 8.0
gi|1942488|pdb|1REQ|A Chain A, Methylmalonyl-Coa Mutase >gnl|BL_... 36 8.0
gi|22959840|ref|ZP_00007486.1| COG0474: Cation transport ATPase ... 36 8.0
gi|28829317|gb|AAO51859.1| similar to Homo sapiens (Human). Muci... 36 8.0
gi|7511304|pir||T34513 hypothetical protein ZK783.1 - Caenorhabd... 36 8.0
gi|9366645|emb|CAB95407.1| homocysteine S-methyltransferase, pos... 36 8.0
gi|729333|sp|Q05621|DHPS_CLOBE Dihydropteroate synthase (DHPS) (... 36 8.0
gi|41323415|gb|AAR99876.1| strubbelig receptor family 8 [Arabido... 36 8.0
gi|48767152|ref|ZP_00271513.1| COG1960: Acyl-CoA dehydrogenases ... 36 8.0
>gi|17535405|ref|NP_496353.1| 5-methyltetrahydrofolate-homocysteine
methyltransferase (138.9 kD) (2L219) [Caenorhabditis
elegans]
gi|3122392|sp|Q09582|METH_CAEEL Probable methionine synthase
(5-methyltetrahydrofolate--homocysteine
methyltransferase) (Methionine synthase, vitamin-B12
dependent) (MS)
gi|7506203|pir||T23868 5-methyltetrahydrofolate-homocysteine
S-methyltransferase (EC 2.1.1.13) R03D7.1 [similarity] -
Caenorhabditis elegans
gi|3878791|emb|CAA86855.1| Hypothetical protein R03D7.1
[Caenorhabditis elegans]
Length = 1249
Score = 2453 bits (6357), Expect = 0.0
Identities = 1228/1249 (98%), Positives = 1228/1249 (98%)
Frame = +1
Query: 1 MTRSSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSI 180
MTRSSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSI
Sbjct: 1 MTRSSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSI 60
Query: 181 TRPDIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDV 360
TRPDIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDV
Sbjct: 61 TRPDIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDV 120
Query: 361 GAATGRRRYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLL 540
GAATGRRRYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLL
Sbjct: 121 GAATGRRRYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLL 180
Query: 541 VETVFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQG 720
VETVFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQG
Sbjct: 181 VETVFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQG 240
Query: 721 KPMAVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREF 900
KPMAVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREF
Sbjct: 241 KPMAVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREF 300
Query: 901 ARDGLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNF 1080
ARDGLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNF
Sbjct: 301 ARDGLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNF 360
Query: 1081 VNIGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKF 1260
VNIGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKF
Sbjct: 361 VNIGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKF 420
Query: 1261 LRLISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRY 1440
LRLISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRY
Sbjct: 421 LRLISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRY 480
Query: 1441 GAAVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHS 1620
GAAVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHS
Sbjct: 481 GAAVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHS 540
Query: 1621 NYGMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGI 1800
NYGMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGI
Sbjct: 541 NYGMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGI 600
Query: 1801 VNAGALPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEMXXXXXXXXXXXXEWRSLT 1980
VNAGALPVYEDIDKP FNRDPEATEKLLVAAQEM EWRSLT
Sbjct: 601 VNAGALPVYEDIDKPLLQLLEDLLFNRDPEATEKLLVAAQEMKKDGKKADTKTDEWRSLT 660
Query: 1981 VEERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFL 2160
VEERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFL
Sbjct: 661 VEERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFL 720
Query: 2161 PQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKN 2340
PQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKN
Sbjct: 721 PQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKN 780
Query: 2341 IVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRV 2520
IVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRV
Sbjct: 781 IVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRV 840
Query: 2521 GLNIPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLN 2700
GLNIPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLN
Sbjct: 841 GLNIPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLN 900
Query: 2701 EDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIP 2880
EDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIP
Sbjct: 901 EDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIP 960
Query: 2881 YIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAV 3060
YIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAV
Sbjct: 961 YIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAV 1020
Query: 3061 VSFLPAASEGDDMHVYDPETGNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDDY 3240
VSFLPAASEGDDMHVYDPETGNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDDY
Sbjct: 1021 VSFLPAASEGDDMHVYDPETGNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDDY 1080
Query: 3241 LGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYSTN 3420
LGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYSTN
Sbjct: 1081 LGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYSTN 1140
Query: 3421 EDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKNGIGLTEHLAMLPAASVS 3600
EDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKNGIGLTEHLAMLPAASVS
Sbjct: 1141 EDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKNGIGLTEHLAMLPAASVS 1200
Query: 3601 GLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGYDTD 3747
GLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGYDTD
Sbjct: 1201 GLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGYDTD 1249
>gi|39591176|emb|CAE73229.1| Hypothetical protein CBG20636
[Caenorhabditis briggsae]
Length = 1249
Score = 2330 bits (6039), Expect = 0.0
Identities = 1156/1249 (92%), Positives = 1194/1249 (95%)
Frame = +1
Query: 1 MTRSSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSI 180
MTRSSLF+ELA+IAKERIMIIDGAMGTMIQREYMEE DFRGEILKDHDKPLKGNNDLLSI
Sbjct: 1 MTRSSLFKELADIAKERIMIIDGAMGTMIQREYMEEHDFRGEILKDHDKPLKGNNDLLSI 60
Query: 181 TRPDIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDV 360
TRPDIIYKIHKLYLEAGADF+ETNTFSGTTIAQADY CEHLVHEINYQSALVARRACDDV
Sbjct: 61 TRPDIIYKIHKLYLEAGADFIETNTFSGTTIAQADYHCEHLVHEINYQSALVARRACDDV 120
Query: 361 GAATGRRRYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLL 540
GAATG RRYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLL
Sbjct: 121 GAATGIRRYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLL 180
Query: 541 VETVFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQG 720
VETVFDSANAKAALFAIRTLFEDEGVPE+PVFLSGTIVDMSGRTLSGQTGEAFLVSTKQG
Sbjct: 181 VETVFDSANAKAALFAIRTLFEDEGVPEIPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQG 240
Query: 721 KPMAVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREF 900
KP+AVGLNCALGAKDMRQFV NMS WSD+ I+CYPNAGLPNALGGYDETPEEMA+VLREF
Sbjct: 241 KPIAVGLNCALGAKDMRQFVQNMSLWSDTLILCYPNAGLPNALGGYDETPEEMAEVLREF 300
Query: 901 ARDGLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNF 1080
A+DGLVNIIGGCCGTTPDHINAMYKAVQGI+PRVPP DPHAGKMLLSGLEPSIVGPETNF
Sbjct: 301 AQDGLVNIIGGCCGTTPDHINAMYKAVQGISPRVPPADPHAGKMLLSGLEPSIVGPETNF 360
Query: 1081 VNIGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKF 1260
VNIGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKF
Sbjct: 361 VNIGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKF 420
Query: 1261 LRLISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRY 1440
LRLISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARI+KRY
Sbjct: 421 LRLISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIVKRY 480
Query: 1441 GAAVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHS 1620
GAAVVVMAFDE+GQAAET+ KFEICERSYRILTEEVGFNPNDIIFDANILTIATGM+EH+
Sbjct: 481 GAAVVVMAFDEEGQAAETERKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMDEHA 540
Query: 1621 NYGMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGI 1800
NYGMYFIEA RMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGI
Sbjct: 541 NYGMYFIEATRMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGI 600
Query: 1801 VNAGALPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEMXXXXXXXXXXXXEWRSLT 1980
VNAGALPVYEDIDKP FNRDPEATEKLLVAAQEM EWR+ +
Sbjct: 601 VNAGALPVYEDIDKPLLQLLEDLLFNRDPEATEKLLVAAQEMKKDGKKADTKTDEWRNTS 660
Query: 1981 VEERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFL 2160
VEERLKFALVKG+DQFVVADTEEARQNT KYPRPLNVIERPLMDGMAVVGELFGAGKMFL
Sbjct: 661 VEERLKFALVKGIDQFVVADTEEARQNTEKYPRPLNVIERPLMDGMAVVGELFGAGKMFL 720
Query: 2161 PQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKN 2340
PQVIKSARVMKKAVAHLLPFM+ ERQANIE MGL EDESPYQGTVVIATVKGDVHDIGKN
Sbjct: 721 PQVIKSARVMKKAVAHLLPFMDAERQANIEKMGLDEDESPYQGTVVIATVKGDVHDIGKN 780
Query: 2341 IVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRV 2520
IV+VVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMV+VAKEMNRV
Sbjct: 781 IVAVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVHVAKEMNRV 840
Query: 2521 GLNIPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLN 2700
GL IPLLIGGATTSKTHTAVKI+PRYPHPVVHCLDASKSVVVCSSLSDM+VRDAFLQDLN
Sbjct: 841 GLKIPLLIGGATTSKTHTAVKIAPRYPHPVVHCLDASKSVVVCSSLSDMTVRDAFLQDLN 900
Query: 2701 EDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIP 2880
EDYEDVRQEHY SLKDRRF L KTREKKF IDW+KF+ VKPSF+GRRE+QNFD ELIP
Sbjct: 901 EDYEDVRQEHYESLKDRRFVALGKTREKKFNIDWNKFSPVKPSFIGRREFQNFDFKELIP 960
Query: 2881 YIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAV 3060
YIDWKPFFDVWQLRGKYPNRSYPKIFDDADVG EAK+VFDDAQTWLKKLIDEK+L ANAV
Sbjct: 961 YIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGGEAKRVFDDAQTWLKKLIDEKVLTANAV 1020
Query: 3061 VSFLPAASEGDDMHVYDPETGNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDDY 3240
VSFLPAASEGDD+HVYDPETGNKLDTFYGLRQQSGREHDQ HFCLSDFI+PLK GVPDDY
Sbjct: 1021 VSFLPAASEGDDIHVYDPETGNKLDTFYGLRQQSGREHDQSHFCLSDFIRPLKIGVPDDY 1080
Query: 3241 LGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYSTN 3420
LGLFACTAGLGAEEYCK LE+NHDDYASIMVKALADRLAEAYAEYLHKEVR LWGYSTN
Sbjct: 1081 LGLFACTAGLGAEEYCKVLEENHDDYASIMVKALADRLAEAYAEYLHKEVRVNLWGYSTN 1140
Query: 3421 EDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKNGIGLTEHLAMLPAASVS 3600
E LTE+DLLSIKY+GIRPACGYPSQPDHTEKRTLWKLLEAEKNGI LTEHLAMLPAASVS
Sbjct: 1141 EQLTETDLLSIKYEGIRPACGYPSQPDHTEKRTLWKLLEAEKNGIVLTEHLAMLPAASVS 1200
Query: 3601 GLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGYDTD 3747
GLYFANPQS+YFAVGKID+DQV DYAARKNVPKEEVERWLSPI+GY+ D
Sbjct: 1201 GLYFANPQSQYFAVGKIDEDQVTDYAARKNVPKEEVERWLSPIIGYELD 1249
>gi|37620202|ref|NP_932338.1| 5-methyltetrahydrofolate-homocysteine
methyltransferase [Danio rerio]
gi|20977255|gb|AAM33342.1| methionine synthase [Danio rerio]
gi|28279621|gb|AAH45477.1| 5-methyltetrahydrofolate-homocysteine
methyltransferase [Danio rerio]
Length = 1263
Score = 1607 bits (4160), Expect = 0.0
Identities = 803/1255 (63%), Positives = 977/1255 (76%), Gaps = 9/1255 (0%)
Frame = +1
Query: 10 SSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRP 189
SSL EL E+ ++RI+++DG MGTMIQ+ ++EEE+FRG+ KDH K LKGNND+LSIT+P
Sbjct: 14 SSLRLELTELLQQRILVLDGGMGTMIQQRHLEEEEFRGQEFKDHPKSLKGNNDILSITQP 73
Query: 190 DIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAA 369
D+IY IHK YLEAGAD +ETNTFS T+IAQADY E L + +N SA VARRA DDV A
Sbjct: 74 DVIYSIHKEYLEAGADIIETNTFSSTSIAQADYGMEDLAYRLNKASAEVARRAADDVSAQ 133
Query: 370 TGRRRYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVET 549
TG +R+V GA+GPTN+TLS+SPSVE+PD+RN+TF ELV+AY +Q + L+ GG DVLLVET
Sbjct: 134 TGCKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYAEQVKGLLDGGADVLLVET 193
Query: 550 VFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKPM 729
+FD+ANAKAALFAI LFE E PV +SGTIVD SGRTLSGQTGEAF++S +P+
Sbjct: 194 IFDTANAKAALFAIDRLFE-ESYEARPVLISGTIVDKSGRTLSGQTGEAFVISVSHAQPL 252
Query: 730 AVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFARD 909
+GLNCALGA +MR F++ + K + +F+ICYPNAGLPN GGYDETP+ A L+EFA D
Sbjct: 253 CIGLNCALGASEMRPFIEAIGKSTSAFVICYPNAGLPNTFGGYDETPDVTAAHLKEFAVD 312
Query: 910 GLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVNI 1089
GLVNI+GGCCGTTPDHI A+ ++V+ + PRVPP D ++ MLLSGLEP +GP TNFVNI
Sbjct: 313 GLVNIVGGCCGTTPDHIRAIAESVRHVKPRVPPTDVYSDYMLLSGLEPFRIGPYTNFVNI 372
Query: 1090 GERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLRL 1269
GERCNVAGSR+F LI NY+ A+ +A+ QV+ GAQ+LD+NMD+G+LDG AMS+F L
Sbjct: 373 GERCNVAGSRKFAKLIMAGNYEEALSIAKAQVEMGAQVLDINMDEGMLDGAAAMSRFCNL 432
Query: 1270 ISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGAA 1449
I+SEPD+ K+P+CIDSS+F VI AGL+ QGKC+VNSISLKEGE+ F RAR ++RYGAA
Sbjct: 433 IASEPDICKVPLCIDSSNFSVIEAGLKCCQGKCIVNSISLKEGEQDFLRRARQVRRYGAA 492
Query: 1450 VVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNYG 1629
VVVMAFDE GQA ETD K +IC R+Y +L ++ GFNPNDIIFD NILTI TGMEEHS Y
Sbjct: 493 VVVMAFDEDGQATETDQKVQICSRAYHLLIDQAGFNPNDIIFDPNILTIGTGMEEHSMYA 552
Query: 1630 MYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVNA 1809
+ FI A R+I+E+LPGA VSGG+SN+SFSFRGMEAIREAMH FL++AIK GMDMGIVNA
Sbjct: 553 INFIRATRIIKESLPGARVSGGLSNLSFSFRGMEAIREAMHGAFLYHAIKDGMDMGIVNA 612
Query: 1810 GALPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEMXXXXXXXXXXXXEWRSLTVEE 1989
G LPVY+DIDK +NRDP+ATEKLL+ AQ EWR+ +VEE
Sbjct: 613 GNLPVYDDIDKELLLLCENIIWNRDPDATEKLLLYAQN-NAKGGKKVVQTDEWRTGSVEE 671
Query: 1990 RLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFLPQV 2169
RL++ALVKG++++VV DTEEAR T +YPRPL+VIE PLM+GM VG+LFGAGKMFLPQV
Sbjct: 672 RLEYALVKGIEKYVVEDTEEARAQTERYPRPLHVIEGPLMNGMKTVGDLFGAGKMFLPQV 731
Query: 2170 IKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKNIVS 2349
IKSARVMKKAV HL+PFME ER+ + T G E+ PYQGTV++ATVKGDVHDIGKNIV
Sbjct: 732 IKSARVMKKAVGHLIPFMEKEREEMMATSGCVEEVDPYQGTVLLATVKGDVHDIGKNIVG 791
Query: 2350 VVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRVGLN 2529
VVLGCNNF+V+DLGVM PC+ I++ AI KAD IGLSGLITPSLDEM++VAKEM R+GL
Sbjct: 792 VVLGCNNFRVIDLGVMIPCDRILREAIHNKADIIGLSGLITPSLDEMIHVAKEMERLGLK 851
Query: 2530 IPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLNEDY 2709
IPLLIGGATTSKTHTAVKI+PRY PVVH LDAS+SVVVCS L D VRD + +++ E+Y
Sbjct: 852 IPLLIGGATTSKTHTAVKIAPRYSSPVVHVLDASRSVVVCSQLLDEGVRDDYFEEVQEEY 911
Query: 2710 EDVRQEHYASLKDRRFTDLNKTREKKFKIDW-DKFTAVKPSFVGRREYQNFDLNELIPYI 2886
ED+RQ+HY SLKDRRF L++ REK IDW + V+P F+G + +DL +L+ +I
Sbjct: 912 EDIRQDHYDSLKDRRFLSLSRAREKGLHIDWFAQPKPVRPQFLGTHVFDTYDLRKLVDFI 971
Query: 2887 DWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAVVS 3066
DWKPFFDVWQLRGKYPNR YPKIF D VG A++V DDA L +LID + L A +V
Sbjct: 972 DWKPFFDVWQLRGKYPNRGYPKIFKDKTVGEGARRVHDDALKLLNRLIDSRGLQARGIVG 1031
Query: 3067 FLPAASEGDDMHVY-----DPETGNKLDTFYGLRQQSGRE--HDQPHFCLSDFIKPLKNG 3225
F A S+GDD+H+Y P T + T +GLRQQ+ ++ +P+ C+SDF+ P +G
Sbjct: 1032 FWAAQSDGDDIHLYTDDVTSPNT-TPVATSHGLRQQAEKDSASSEPYLCVSDFVAPRSSG 1090
Query: 3226 VPDDYLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLW 3405
V DY+GLFA + GAEE + +K DDY SIMVKALADRLAEA+AE LH VR LW
Sbjct: 1091 V-QDYVGLFAVSV-FGAEELSQKFKKQGDDYRSIMVKALADRLAEAFAEELHVRVRRDLW 1148
Query: 3406 GYSTNEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLE-AEKNGIGLTEHLAML 3582
GYS+ EDL SDL ++Y+GIRPA GYPSQPDH+EK T+WKL + EK GI LTE LAM
Sbjct: 1149 GYSSEEDLPASDLHKLRYEGIRPAAGYPSQPDHSEKLTMWKLADIQEKTGISLTESLAMS 1208
Query: 3583 PAASVSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGYDTD 3747
PAASVSGLYF+NP+S YFAVGKI ++QV DYA RK + EVERWL PILGYDTD
Sbjct: 1209 PAASVSGLYFSNPKSTYFAVGKITKEQVEDYALRKQMEVCEVERWLGPILGYDTD 1263
>gi|2842762|sp|Q99707|METH_HUMAN Methionine synthase
(5-methyltetrahydrofolate--homocysteine
methyltransferase) (Methionine synthase, vitamin-B12
dependent) (MS)
gi|1763269|gb|AAB39704.1| methionine synthase [Homo sapiens]
gi|1923221|gb|AAC51188.1| 5-methyltetrahydrofolate-homocysteine
methyltransferase [Homo sapiens]
Length = 1265
Score = 1603 bits (4152), Expect = 0.0
Identities = 788/1255 (62%), Positives = 990/1255 (78%), Gaps = 8/1255 (0%)
Frame = +1
Query: 7 RSSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITR 186
+ +L +E+ I ++RIM++DG MGTMIQRE + EE FRG+ KDH +PLKGNND+LSIT+
Sbjct: 15 KKTLRDEINAILQKRIMVLDGGMGTMIQREKLNEEHFRGQEFKDHARPLKGNNDILSITQ 74
Query: 187 PDIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGA 366
PD+IY+IHK YL AGAD +ETNTFS T+IAQADY EHL + +N SA VAR+A ++V
Sbjct: 75 PDVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNMCSAGVARKAAEEVTL 134
Query: 367 ATGRRRYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVE 546
TG +R+V GA+GPTN+TLS+SPSVE+PD+RN+TF ELV+AY +QA+ L+ GGVD+LL+E
Sbjct: 135 QTGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQAKGLLDGGVDILLIE 194
Query: 547 TVFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKP 726
T+FD+ANAKAALFA++ LFE++ P P+F+SGTIVD SGRTLSGQTGE F++S G+P
Sbjct: 195 TIFDTANAKAALFALQNLFEEKYAPR-PIFISGTIVDKSGRTLSGQTGEGFVISVSHGEP 253
Query: 727 MAVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFAR 906
+ +GLNCALGA +MR F++ + K + ++++CYPNAGLPN G YDETP MA L++FA
Sbjct: 254 LCIGLNCALGAAEMRPFIEIIGKCTTAYVLCYPNAGLPNTFGDYDETPSMMAKHLKDFAM 313
Query: 907 DGLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVN 1086
DGLVNI+GGCCG+TPDHI + +AV+ PRVPP G MLLSGLEP +GP TNFVN
Sbjct: 314 DGLVNIVGGCCGSTPDHIREIAEAVKNCKPRVPPATAFEGHMLLSGLEPFRIGPYTNFVN 373
Query: 1087 IGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLR 1266
IGERCNVAGSR+F LI NY+ A+ VA+VQV+ GAQ+LDVNMDDG+LDGP AM++F
Sbjct: 374 IGERCNVAGSRKFAKLIMAGNYEEALCVAKVQVEMGAQVLDVNMDDGMLDGPSAMTRFCN 433
Query: 1267 LISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGA 1446
LI+SEPD+AK+P+CIDSS+F VI AGL+ QGKC+VNSISLKEGE+ F E+AR IK+YGA
Sbjct: 434 LIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEDDFLEKARKIKKYGA 493
Query: 1447 AVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNY 1626
A+VVMAFDE+GQA ETD K +C R+Y +L +++GFNPNDIIFD NILTI TGMEEH+ Y
Sbjct: 494 AMVVMAFDEEGQATETDTKIRVCTRAYHLLVKKLGFNPNDIIFDPNILTIGTGMEEHNLY 553
Query: 1627 GMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVN 1806
+ FI A ++I+E LPGA +SGG+SN+SFSFRGMEAIREAMH VFL++AIK+GMDMGIVN
Sbjct: 554 AINFIHATKVIKETLPGARISGGLSNLSFSFRGMEAIREAMHGVFLYHAIKSGMDMGIVN 613
Query: 1807 AGALPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEMXXXXXXXXXXXXEWRSLTVE 1986
AG LPVY+DI K +N+DPEATEKLL AQ EWR+ VE
Sbjct: 614 AGNLPVYDDIHKELLQLCEDLIWNKDPEATEKLLRYAQTQ-GTGGKKVIQTDEWRNGPVE 672
Query: 1987 ERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFLPQ 2166
ERL++ALVKG+++ ++ DTEEAR N KYPRPLN+IE PLM+GM +VG+LFGAGKMFLPQ
Sbjct: 673 ERLEYALVKGIEKHIIEDTEEARLNQKKYPRPLNIIEGPLMNGMKIVGDLFGAGKMFLPQ 732
Query: 2167 VIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKNIV 2346
VIKSARVMKKAV HL+PFME ER+ G E+E PYQGT+V+ATVKGDVHDIGKNIV
Sbjct: 733 VIKSARVMKKAVGHLIPFMEKEREETRVLNGTVEEEDPYQGTIVLATVKGDVHDIGKNIV 792
Query: 2347 SVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRVGL 2526
VVLGCNNF+V+DLGVMTPC+ I+KAA++ KAD IGLSGLITPSLDEM++VAKEM R+ +
Sbjct: 793 GVVLGCNNFRVIDLGVMTPCDKILKAALDHKADIIGLSGLITPSLDEMIFVAKEMERLAI 852
Query: 2527 NIPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLNED 2706
IPLLIGGATTSKTHTAVKI+PRY PV+H LDASKSVVVCS L D +++D + +++ E+
Sbjct: 853 RIPLLIGGATTSKTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLDENLKDEYFEEIMEE 912
Query: 2707 YEDVRQEHYASLKDRRFTDLNKTREKKFKIDW-DKFTAVKPSFVGRREYQNFDLNELIPY 2883
YED+RQ+HY SLK+RR+ L++ R+ F++DW + VKP+F+G + ++++DL +L+ Y
Sbjct: 913 YEDIRQDHYESLKERRYLPLSQARKSGFQMDWLSEPHPVKPTFIGTQVFEDYDLQKLVDY 972
Query: 2884 IDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAVV 3063
IDWKPFFDVWQLRGKYPNR +PKIF+D VG EA+KV+DDA L LI +K L A VV
Sbjct: 973 IDWKPFFDVWQLRGKYPNRGFPKIFNDKTVGGEARKVYDDAHNMLNTLISQKKLRARGVV 1032
Query: 3064 SFLPAASEGDDMHVYD----PETGNKLDTFYGLRQQSGRE--HDQPHFCLSDFIKPLKNG 3225
F PA S DD+H+Y P+ + TFYGLRQQ+ ++ +P++CLSDFI PL +G
Sbjct: 1033 GFWPAQSIQDDIHLYAEAAVPQAAEPIATFYGLRQQAEKDSASTEPYYCLSDFIAPLHSG 1092
Query: 3226 VPDDYLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLW 3405
+ DYLGLFA A G EE K E + DDY+SIMVKAL DRLAEA+AE LH+ VR LW
Sbjct: 1093 I-RDYLGLFA-VACFGVEELSKAYEDDGDDYSSIMVKALGDRLAEAFAEELHERVRRELW 1150
Query: 3406 GYSTNEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKN-GIGLTEHLAML 3582
Y +E L +DL ++Y+GIRPA GYPSQPDHTEK T+W+L + E++ GI LTE LAM
Sbjct: 1151 AYCGSEQLDVADLRRLRYKGIRPAPGYPSQPDHTEKLTMWRLADIEQSTGIRLTESLAMA 1210
Query: 3583 PAASVSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGYDTD 3747
PA++VSGLYF+N +S+YFAVGKI +DQV DYA RKN+ EVE+WL PILGYDTD
Sbjct: 1211 PASAVSGLYFSNLKSKYFAVGKISKDQVEDYALRKNISVAEVEKWLGPILGYDTD 1265
>gi|4557765|ref|NP_000245.1| 5-methyltetrahydrofolate-homocysteine
methyltransferase; 5-methyltetrahydrofolate-homocysteine
methyltransferase 1 [Homo sapiens]
gi|2160699|gb|AAB58906.1| methionine synthase [Homo sapiens]
Length = 1265
Score = 1603 bits (4150), Expect = 0.0
Identities = 788/1255 (62%), Positives = 990/1255 (78%), Gaps = 8/1255 (0%)
Frame = +1
Query: 7 RSSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITR 186
+ +L +E+ I ++RIM++DG MGTMIQRE + EE FRG+ KDH +PLKGNND+LSIT+
Sbjct: 15 KKTLRDEINAILQKRIMVLDGGMGTMIQREKLNEEHFRGQEFKDHARPLKGNNDILSITQ 74
Query: 187 PDIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGA 366
PD+IY+IHK YL AGAD +ETNTFS T+IAQADY EHL + +N SA VAR+A ++V
Sbjct: 75 PDVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNMCSAGVARKAAEEVTL 134
Query: 367 ATGRRRYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVE 546
TG +R+V GA+GPTN+TLS+SPSVE+PD+RN+TF ELV+AY +QA+ L+ GGVD+LL+E
Sbjct: 135 QTGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQAKGLLDGGVDILLIE 194
Query: 547 TVFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKP 726
T+FD+ANAKAALFA++ LFE++ P P+F+SGTIVD SGRTLSGQTGE F++S G+P
Sbjct: 195 TIFDTANAKAALFALQNLFEEKYAPR-PIFISGTIVDKSGRTLSGQTGEGFVISVSHGEP 253
Query: 727 MAVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFAR 906
+ +GLNCALGA +MR F++ + K + ++++CYPNAGLPN G YDETP MA L++FA
Sbjct: 254 LYIGLNCALGAAEMRPFIEIIGKCTTAYVLCYPNAGLPNTFGDYDETPSMMAKHLKDFAM 313
Query: 907 DGLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVN 1086
DGLVNI+GGCCG+TPDHI + +AV+ PRVPP G MLLSGLEP +GP TNFVN
Sbjct: 314 DGLVNIVGGCCGSTPDHIREIAEAVKNCKPRVPPATAFEGHMLLSGLEPFRIGPYTNFVN 373
Query: 1087 IGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLR 1266
IGERCNVAGSR+F LI NY+ A+ VA+VQV+ GAQ+LDVNMDDG+LDGP AM++F
Sbjct: 374 IGERCNVAGSRKFAKLIMAGNYEEALCVAKVQVEMGAQVLDVNMDDGMLDGPSAMTRFCN 433
Query: 1267 LISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGA 1446
LI+SEPD+AK+P+CIDSS+F VI AGL+ QGKC+VNSISLKEGE+ F E+AR IK+YGA
Sbjct: 434 LIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEDDFLEKARKIKKYGA 493
Query: 1447 AVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNY 1626
A+VVMAFDE+GQA ETD K +C R+Y +L +++GFNPNDIIFD NILTI TGMEEH+ Y
Sbjct: 494 AMVVMAFDEEGQATETDTKIRVCTRAYHLLVKKLGFNPNDIIFDPNILTIGTGMEEHNLY 553
Query: 1627 GMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVN 1806
+ FI A ++I+E LPGA +SGG+SN+SFSFRGMEAIREAMH VFL++AIK+GMDMGIVN
Sbjct: 554 AINFIHATKVIKETLPGARISGGLSNLSFSFRGMEAIREAMHGVFLYHAIKSGMDMGIVN 613
Query: 1807 AGALPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEMXXXXXXXXXXXXEWRSLTVE 1986
AG LPVY+DI K +N+DPEATEKLL AQ EWR+ VE
Sbjct: 614 AGNLPVYDDIHKELLQLCEDLIWNKDPEATEKLLRYAQTQ-GTGGKKVIQTDEWRNGPVE 672
Query: 1987 ERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFLPQ 2166
ERL++ALVKG+++ ++ DTEEAR N KYPRPLN+IE PLM+GM +VG+LFGAGKMFLPQ
Sbjct: 673 ERLEYALVKGIEKHIIEDTEEARLNQKKYPRPLNIIEGPLMNGMKIVGDLFGAGKMFLPQ 732
Query: 2167 VIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKNIV 2346
VIKSARVMKKAV HL+PFME ER+ G E+E PYQGT+V+ATVKGDVHDIGKNIV
Sbjct: 733 VIKSARVMKKAVGHLIPFMEKEREETRVLNGTVEEEDPYQGTIVLATVKGDVHDIGKNIV 792
Query: 2347 SVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRVGL 2526
VVLGCNNF+V+DLGVMTPC+ I+KAA++ KAD IGLSGLITPSLDEM++VAKEM R+ +
Sbjct: 793 GVVLGCNNFRVIDLGVMTPCDKILKAALDHKADIIGLSGLITPSLDEMIFVAKEMERLAI 852
Query: 2527 NIPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLNED 2706
IPLLIGGATTSKTHTAVKI+PRY PV+H LDASKSVVVCS L D +++D + +++ E+
Sbjct: 853 RIPLLIGGATTSKTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLDENLKDEYFEEIMEE 912
Query: 2707 YEDVRQEHYASLKDRRFTDLNKTREKKFKIDW-DKFTAVKPSFVGRREYQNFDLNELIPY 2883
YED+RQ+HY SLK+RR+ L++ R+ F++DW + VKP+F+G + ++++DL +L+ Y
Sbjct: 913 YEDIRQDHYESLKERRYLPLSQARKSGFQMDWLSEPHPVKPTFIGTQVFEDYDLQKLVDY 972
Query: 2884 IDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAVV 3063
IDWKPFFDVWQLRGKYPNR +PKIF+D VG EA+KV+DDA L LI +K L A VV
Sbjct: 973 IDWKPFFDVWQLRGKYPNRGFPKIFNDKTVGGEARKVYDDAHNMLNTLISQKKLRARGVV 1032
Query: 3064 SFLPAASEGDDMHVYD----PETGNKLDTFYGLRQQSGRE--HDQPHFCLSDFIKPLKNG 3225
F PA S DD+H+Y P+ + TFYGLRQQ+ ++ +P++CLSDFI PL +G
Sbjct: 1033 GFWPAQSIQDDIHLYAEAAVPQAAEPIATFYGLRQQAEKDSASTEPYYCLSDFIAPLHSG 1092
Query: 3226 VPDDYLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLW 3405
+ DYLGLFA A G EE K E + DDY+SIMVKAL DRLAEA+AE LH+ VR LW
Sbjct: 1093 I-RDYLGLFA-VACFGVEELSKAYEDDGDDYSSIMVKALGDRLAEAFAEELHERVRRELW 1150
Query: 3406 GYSTNEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKN-GIGLTEHLAML 3582
Y +E L +DL ++Y+GIRPA GYPSQPDHTEK T+W+L + E++ GI LTE LAM
Sbjct: 1151 AYCGSEQLDVADLRRLRYKGIRPAPGYPSQPDHTEKLTMWRLADIEQSTGIRLTESLAMA 1210
Query: 3583 PAASVSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGYDTD 3747
PA++VSGLYF+N +S+YFAVGKI +DQV DYA RKN+ EVE+WL PILGYDTD
Sbjct: 1211 PASAVSGLYFSNLKSKYFAVGKISKDQVEDYALRKNISVAEVEKWLGPILGYDTD 1265
>gi|13540691|ref|NP_110491.1| methionine synthase [Rattus norvegicus]
gi|7433421|pir||T42376 5-methyltetrahydrofolate-homocysteine
S-methyltransferase (EC 2.1.1.13) - rat
gi|3978143|gb|AAD05384.1| methionine synthase; MS [Rattus norvegicus]
Length = 1253
Score = 1582 bits (4096), Expect = 0.0
Identities = 778/1255 (61%), Positives = 979/1255 (77%), Gaps = 8/1255 (0%)
Frame = +1
Query: 7 RSSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITR 186
+ +L +E+ I ++RIM++DG MGTMIQR + EE+F+G+ KDH +PLKGNND+LSIT+
Sbjct: 2 KKTLQDEIEAILRKRIMVLDGGMGTMIQRYKLSEENFQGQEFKDHSRPLKGNNDILSITQ 61
Query: 187 PDIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGA 366
PD+IY+IHK YL AGAD +ETNTFS T+IAQADY EHL + +N SA VAR+A +++
Sbjct: 62 PDVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNKCSADVARKAAEEITL 121
Query: 367 ATGRRRYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVE 546
TG +R+V G++GPTN+TLS+SPSVE+PD+RN+TF ELV+AY +QA+ L+ GGVD+LL+E
Sbjct: 122 QTGVKRFVAGSLGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQAKGLLDGGVDILLIE 181
Query: 547 TVFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKP 726
T+FD+ANAKAALFA++ LFE+ P+F+SGTIVD SGRTLSGQTGEAF+ S P
Sbjct: 182 TIFDTANAKAALFALQKLFEENYASPRPIFISGTIVDKSGRTLSGQTGEAFVTSVSHSDP 241
Query: 727 MAVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFAR 906
+ +GLNCALGA +MR F++ + K + ++++CYPNAGLPN G YDETP MA L++FA
Sbjct: 242 LCIGLNCALGAAEMRPFIETIGKCTTAYVLCYPNAGLPNTFGDYDETPAMMAMHLKDFAV 301
Query: 907 DGLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVN 1086
DGLVN++GGCCG+TPDHI + +AV+ PRVPP G MLLSGLEP +GP TNFVN
Sbjct: 302 DGLVNVVGGCCGSTPDHIREIAEAVKNCKPRVPPDSVFEGHMLLSGLEPFRIGPYTNFVN 361
Query: 1087 IGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLR 1266
IGERCNVAGS++F LI NY+ A+ VA+VQV+ GAQ+LD+NMDDG+LDGP AM+KF
Sbjct: 362 IGERCNVAGSKKFAKLIMAGNYEEALSVAKVQVEMGAQVLDINMDDGMLDGPSAMTKFCN 421
Query: 1267 LISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGA 1446
I+SEPD+AK+P+CIDSS+F VI AGL+ QGKC+VNSISLKEGEE F E+AR IK++GA
Sbjct: 422 FIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEEDFLEKARKIKKFGA 481
Query: 1447 AVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNY 1626
AVVVMAFDE+GQA ETD K +C R+Y +L E+VGFNPNDIIFD NILTI TGMEEH+ Y
Sbjct: 482 AVVVMAFDEEGQATETDVKVSVCTRAYHLLVEKVGFNPNDIIFDPNILTIGTGMEEHNLY 541
Query: 1627 GMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVN 1806
+ FI A R+I+E LPG +SGG+SN+SF+FRGM+AIREAMH VFL++AIK GMDMGIVN
Sbjct: 542 AINFIHATRVIKETLPGVRISGGLSNLSFAFRGMDAIREAMHGVFLYHAIKFGMDMGIVN 601
Query: 1807 AGALPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEMXXXXXXXXXXXXEWRSLTVE 1986
AG+LPVY+DI K +NRD EATEKLL AQ EWR+ ++E
Sbjct: 602 AGSLPVYDDIHKDLLQLCEDLIWNRDAEATEKLLRYAQ-THGKGGKKVIQTDEWRNGSIE 660
Query: 1987 ERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFLPQ 2166
ERL++ALVKG+++ +V DTEEAR N KYPRPLN+IE PLM+GM VVG+LFGAGKMFLPQ
Sbjct: 661 ERLEYALVKGIEKHIVEDTEEARLNREKYPRPLNIIEGPLMNGMKVVGDLFGAGKMFLPQ 720
Query: 2167 VIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKNIV 2346
VIKSARVMKKAV HL+PFME ER+ G E+E PYQGT+V+ATVKGDVHDIGKNIV
Sbjct: 721 VIKSARVMKKAVGHLIPFMEKEREEARVLNGSVEEEDPYQGTIVLATVKGDVHDIGKNIV 780
Query: 2347 SVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRVGL 2526
VVLGCNNF+V+DLGVMTPC+ I++AA++ KAD IGLSGLITPSLDEM++VAKEM R+ +
Sbjct: 781 GVVLGCNNFRVIDLGVMTPCDKILQAALDHKADIIGLSGLITPSLDEMIFVAKEMERLAI 840
Query: 2527 NIPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLNED 2706
IPLLIGGATTS+THTAVKI+PRY PV+H LDASKSVVVCS L D +++D + +++ E+
Sbjct: 841 KIPLLIGGATTSRTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLDENLKDDYFEEILEE 900
Query: 2707 YEDVRQEHYASLKDRRFTDLNKTREKKFKIDW-DKFTAVKPSFVGRREYQNFDLNELIPY 2883
YED+RQ+HY SLK+R++ L++ R+ F IDW + VKP+F+G + +++++L +L+ Y
Sbjct: 901 YEDIRQDHYESLKERKYLPLSQARKHSFHIDWLSEPHPVKPTFIGTQVFEDYNLQKLVDY 960
Query: 2884 IDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAVV 3063
IDWKPFFDVWQLRGKYPNR +PKIF+D VG EA+KV++DAQ L LI K L A VV
Sbjct: 961 IDWKPFFDVWQLRGKYPNRGFPKIFNDKAVGEEARKVYEDAQNMLSILISRKKLRARGVV 1020
Query: 3064 SFLPAASEGDDMHVYD----PETGNKLDTFYGLRQQSGREHD--QPHFCLSDFIKPLKNG 3225
F PA S DD+H+Y P+ + TFYGLRQQ+ ++ P+ CLSDF+ PL +G
Sbjct: 1021 GFWPAQSVQDDIHLYAEGAVPQAAEPIATFYGLRQQAEKDSSSTDPYHCLSDFVAPLHSG 1080
Query: 3226 VPDDYLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLW 3405
V DYLGLFA A G EE K E + DDY+SIMVKAL DRLAEA+AE LH+ VR LW
Sbjct: 1081 V-RDYLGLFA-VACFGVEELSKAYEDDGDDYSSIMVKALGDRLAEAFAEELHERVRRELW 1138
Query: 3406 GYSTNEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEK-NGIGLTEHLAML 3582
Y +E L +DL ++Y+GIRPA GYPSQPDHTEK T+W+L E+ GI LTE LAM
Sbjct: 1139 AYCGSEQLGVTDLRKLRYEGIRPAPGYPSQPDHTEKLTMWRLANIEQATGIRLTESLAMA 1198
Query: 3583 PAASVSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGYDTD 3747
PA++VSGLYF+N +S+YFAVGKI +DQ+ DYA RKN+ EVE+WL PILGYDTD
Sbjct: 1199 PASAVSGLYFSNVKSKYFAVGKISKDQIEDYALRKNMSVAEVEKWLGPILGYDTD 1253
>gi|38074217|ref|XP_138431.3| 5-methyltetrahydrofolate-homocysteine
methyltransferase [Mus musculus]
Length = 1218
Score = 1490 bits (3857), Expect = 0.0
Identities = 751/1259 (59%), Positives = 939/1259 (73%), Gaps = 12/1259 (0%)
Frame = +1
Query: 7 RSSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITR 186
+ +L +E+ I ++RIM++DG MGTMIQR + EE F+G+ KDH +PLKGNND+LSIT+
Sbjct: 2 KKTLQDEIEAILRKRIMVLDGGMGTMIQRYKLSEEHFQGQEFKDHSRPLKGNNDILSITQ 61
Query: 187 PDIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGA 366
PDIIY+IHK YL AGAD +ETNTFS T+IAQADY EHL + +N SA VAR+A +++
Sbjct: 62 PDIIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNKCSADVARKAAEEITL 121
Query: 367 ATGRRRYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVE 546
TG +R+V GA+GPTN+TLS+SPSVE+PD+RN+TF ELV AY +QA+ L+ G VD+LL+E
Sbjct: 122 QTGVKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVDAYQEQAKGLLDGRVDILLIE 181
Query: 547 TVFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKP 726
T+FD+ANAKAALFAI+ LFE+ P P+F+SGTIVD SGRTLSGQTGEAF+ S P
Sbjct: 182 TIFDTANAKAALFAIQNLFEENYAPPRPIFISGTIVDKSGRTLSGQTGEAFVTSVSHSDP 241
Query: 727 MAVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFAR 906
+ +GLNC+LGA +MR F++ + K + ++++CYPNAGLPN G YDETP MA L++FA
Sbjct: 242 LCIGLNCSLGAAEMRPFIETIGKCTTAYVLCYPNAGLPNTFGDYDETPSTMATHLKDFAV 301
Query: 907 DGLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVN 1086
DGLVNI+GGCCG+TPDHI + +AV+ PRVPP G MLLSGLEP +GP TNFVN
Sbjct: 302 DGLVNIVGGCCGSTPDHIREIAEAVKKCKPRVPPASVFEGHMLLSGLEPFRIGPYTNFVN 361
Query: 1087 IGERCNVAGSRRFCNLIKNENYDT----AIDVARVQVDSGAQILDVNMDDGLLDGPYAMS 1254
IGERCNVAGSR+F LI NY+ A+ +A+ QV+ GAQ+LD+NMDDG+LDGP AM+
Sbjct: 362 IGERCNVAGSRKFAKLIMAGNYEVSILEALSIAKAQVEMGAQVLDINMDDGMLDGPSAMT 421
Query: 1255 KFLRLISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIK 1434
+F I+SEPD+AK+P+CIDSS+F VI AGL+ QGKC+VNSISLKEGE F E+AR IK
Sbjct: 422 RFCNSIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEGDFLEKARKIK 481
Query: 1435 RYGAAVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEE 1614
++GAAVVVMAFDE+GQA ETD K +C R+Y +L ++VGFNPNDIIFD NILTI TGMEE
Sbjct: 482 KFGAAVVVMAFDEEGQATETDVKVNVCTRAYHLLVDKVGFNPNDIIFDPNILTIGTGMEE 541
Query: 1615 HSNYGMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDM 1794
H+ Y + FI A R+I K GMDM
Sbjct: 542 HNLYAINFIHATRVI---------------------------------------KFGMDM 562
Query: 1795 GIVNAGALPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEMXXXXXXXXXXXXEWRS 1974
GIVNAG LPVY+ I K +N+D EATEKLL AQ EWR+
Sbjct: 563 GIVNAGNLPVYDAIHKDLLQLCEDLIWNKDSEATEKLLRYAQT-HGTGGKKVIQTDEWRN 621
Query: 1975 LTVEERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKM 2154
++EERL++ALVKG+++ +V DTEEAR N KYPRPLN+IE PLM+GM VVG+LFGAGKM
Sbjct: 622 GSIEERLEYALVKGIEKHIVEDTEEARLNGEKYPRPLNIIEGPLMNGMKVVGDLFGAGKM 681
Query: 2155 FLPQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIG 2334
FLPQVIKSARVMKKAV HL+PFME ER+ G E+E PYQGT+V+ATVKGDVHDIG
Sbjct: 682 FLPQVIKSARVMKKAVGHLIPFMEKEREEARLINGSVEEEDPYQGTIVLATVKGDVHDIG 741
Query: 2335 KNIVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMN 2514
KNIV VVL CNNF+V+DLGVMTPC+ I++AA++ KAD IGLSGLITPSLDEM++VAKEM
Sbjct: 742 KNIVGVVLACNNFRVIDLGVMTPCDKILQAALDHKADIIGLSGLITPSLDEMIFVAKEME 801
Query: 2515 RVGLNIPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQD 2694
R+ + IPLLIGGATTS+THTAVKI+PRY PV+H LDASKSVVVCS L D ++RD + ++
Sbjct: 802 RLAIKIPLLIGGATTSRTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLDENLRDDYFEE 861
Query: 2695 LNEDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDW-DKFTAVKPSFVGRREYQNFDLNE 2871
+ E+YED+RQ+HY SLK+R++ L++ R+ F IDW + VKP+F+G + +++++L +
Sbjct: 862 ILEEYEDIRQDHYESLKERKYVPLSQARKHGFHIDWLSEPHPVKPTFIGTQVFEDYNLQK 921
Query: 2872 LIPYIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVA 3051
L+ YIDWKPFFDVWQLRGKYPNR +PKIF+D VG EA+KV++DAQ L LI +K L A
Sbjct: 922 LVDYIDWKPFFDVWQLRGKYPNRGFPKIFNDKAVGEEARKVYNDAQNMLNILISQKKLQA 981
Query: 3052 NAVVSFLPAASEGDDMHVYD----PETGNKLDTFYGLRQQSGREHD--QPHFCLSDFIKP 3213
VV F PA S DD+H+Y P+ + TFYGLRQQ+ ++ P+ CLSDFI P
Sbjct: 982 RGVVGFWPAQSVQDDIHLYAEGVVPQAAEPIATFYGLRQQAEKDSSSTDPYHCLSDFIAP 1041
Query: 3214 LKNGVPDDYLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVR 3393
L +GV DYLGLFA A G EE KT E + DDY+SIMVKAL DRLAEA+AE LH+ VR
Sbjct: 1042 LHSGV-CDYLGLFA-VACFGVEELSKTYEDDGDDYSSIMVKALGDRLAEAFAEELHERVR 1099
Query: 3394 TTLWGYSTNEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEK-NGIGLTEH 3570
LW YS +E L DL ++Y+GIRPA GYPSQPDHTEK T+W+L E+ GI LTE
Sbjct: 1100 RELWAYSRSEQLGVPDLRRLRYEGIRPAPGYPSQPDHTEKLTMWRLASIEQATGIRLTES 1159
Query: 3571 LAMLPAASVSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGYDTD 3747
LAM PA++VSGLYF+N +++YFAVGKI +DQ DYA RKN+P EVE+WL PILGYDTD
Sbjct: 1160 LAMAPASAVSGLYFSNVKAKYFAVGKISKDQTEDYALRKNMPVAEVEKWLGPILGYDTD 1218
>gi|41407957|ref|NP_960793.1| MetH [Mycobacterium avium subsp.
paratuberculosis str. k10]
gi|41396311|gb|AAS04176.1| MetH [Mycobacterium avium subsp.
paratuberculosis str. k10]
Length = 1262
Score = 1291 bits (3340), Expect = 0.0
Identities = 682/1255 (54%), Positives = 873/1255 (69%), Gaps = 8/1255 (0%)
Frame = +1
Query: 7 RSSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITR 186
R +EL ++RIM+IDGAMGT IQR+ +E +RGE KD L GNNDLL++T+
Sbjct: 23 RPDCTDELTAALRQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLNLTQ 82
Query: 187 PDIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGA 366
P II IH+ YLEAGAD +ETNTF+ I+ +DY E L +E+NY A +AR+A D+ +
Sbjct: 83 PQIIEGIHREYLEAGADILETNTFNANAISLSDYGMEELSYELNYAGAALARKAADEF-S 141
Query: 367 ATGRRRYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVE 546
+ RYV GA+GPT+RT SISP V P RNVT+ ELV AY + A L+ GGVD+L+VE
Sbjct: 142 TPDKPRYVAGALGPTSRTASISPDVNDPGARNVTYDELVAAYLEAANGLVDGGVDLLIVE 201
Query: 547 TVFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKP 726
T+FD+ NAKAA+FA+ TLFE G PV +SGTI D SGRTLSGQ EAF S + KP
Sbjct: 202 TIFDTLNAKAAVFALETLFEQRG-RRWPVIISGTITDASGRTLSGQVTEAFWNSIRHAKP 260
Query: 727 MAVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFAR 906
+AVGLNCALGA +MR ++ +S+ +D+F+ CYPNAGLPNA G YDE+PE A + +F
Sbjct: 261 IAVGLNCALGAPEMRPYIAEVSRIADTFVSCYPNAGLPNAFGEYDESPERQASYIADFTE 320
Query: 907 DGLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVN 1086
GLVN++GGCCGT P HI + K V+G PR PQ P A + LSGLEP + ++ FVN
Sbjct: 321 AGLVNLVGGCCGTAPPHIAEIAKVVEGKPPREVPQIPVATR--LSGLEPLNITDDSLFVN 378
Query: 1087 IGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLR 1266
IGER N+ GS RF NLIK E+YDTA+ VA QV+ GAQ++D+NMD+G++DG AM +F R
Sbjct: 379 IGERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDGVAAMDRFTR 438
Query: 1267 LISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGA 1446
LI++EPD++++PV IDSS ++VI AGL++ QGK +VNSISLKEGEEKF AR+ ++YGA
Sbjct: 439 LIAAEPDISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISLKEGEEKFVREARLCRKYGA 498
Query: 1447 AVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNY 1626
AVVVMAFDEQGQA + + +IC R+YR+LTEEVGF P DIIFD N +ATG+EEH+ Y
Sbjct: 499 AVVVMAFDEQGQADNLERRKQICARAYRVLTEEVGFPPEDIIFDPNCFALATGIEEHATY 558
Query: 1627 GMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVN 1806
G+ FIEA I+ENLPG H+SGG+SN+SFSFRG +REA+HSVFLF+AIKAG+DMGIVN
Sbjct: 559 GIDFIEACAWIKENLPGVHLSGGISNVSFSFRGNNPVREAIHSVFLFHAIKAGLDMGIVN 618
Query: 1807 AGALPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEM-XXXXXXXXXXXXEWRSLTV 1983
AGAL Y+ ID NR +A E+LL A+ EWR L V
Sbjct: 619 AGALVPYDSIDPELRDRIEDVVLNRREDAAERLLEIAERFNKSADASEDSAAAEWRGLPV 678
Query: 1984 EERLKFALVKGVDQFVVADTEEAR-QNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFL 2160
ER+ ALVKG+D V DTEE R + A RP+ VIE PLMDGM VVG+LFG+GKMFL
Sbjct: 679 RERITHALVKGIDAHVDEDTEELRAEIAAAGGRPIEVIEGPLMDGMNVVGDLFGSGKMFL 738
Query: 2161 PQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKN 2340
PQV+KSARVMKKAVA+LLPF+E E+ E G++ + GT+V+ATVKGDVHDIGKN
Sbjct: 739 PQVVKSARVMKKAVAYLLPFIEAEK----EESGVSGSKDT-NGTIVMATVKGDVHDIGKN 793
Query: 2341 IVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRV 2520
IV VVL CNNF+V+DLGVM P + I+ AA E AD IGLSGLITPSLDEM A EM R
Sbjct: 794 IVGVVLQCNNFEVIDLGVMVPAQKILDAAKEHDADIIGLSGLITPSLDEMSNFAAEMERE 853
Query: 2521 GLNIPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLN 2700
GL IPLLIGGATTS+ HTAVKISPR PVV DAS+SV V ++L D R A L+
Sbjct: 854 GLQIPLLIGGATTSRAHTAVKISPRRSGPVVWVKDASRSVPVAAALLDDKQRPALLEATE 913
Query: 2701 EDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSF-VGRREYQNFDLNELI 2877
+DY +R+ H A +R L K R + IDWD +T P+ G RE+Q++DL EL
Sbjct: 914 KDYASLRERH-AQKNERPMVTLEKARANRTPIDWDGYTPPVPAIGAGIREFQDYDLAELR 972
Query: 2878 PYIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANA 3057
YIDW+PFF+ W+++G++P+ I ++ G A+K++DDAQ L LI+EK L NA
Sbjct: 973 EYIDWQPFFNAWEMKGRFPD-----ILNNPATGEAARKLYDDAQEMLDTLIEEKWLTPNA 1027
Query: 3058 VVSFLPAASEG---DDMHVYDPETGNK-LDTFYGLRQQSGREHDQPHFCLSDFIKPLKNG 3225
V+ F PA + G +D+ +Y +T + L T + LRQQ P+ L DFI P + G
Sbjct: 1028 VIGFFPANAIGPGFEDIELYTDDTRTEVLTTLHNLRQQGEHRDGIPNRSLGDFIAPKETG 1087
Query: 3226 VPDDYLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLW 3405
DY+G FA TAGLG++E + DDY++I+++++ADRLAEA+AE +H+ VR W
Sbjct: 1088 -HRDYIGAFAVTAGLGSQEKIAEFKAALDDYSAILLESIADRLAEAFAERMHQRVRKEFW 1146
Query: 3406 GYSTNEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEA-EKNGIGLTEHLAML 3582
GY +E L L+ KY+GIRPA GYP+ P+HTEK TLWKL++ E+ GI LTE +AM
Sbjct: 1147 GYQPDEQLDNDALIDEKYRGIRPAPGYPACPEHTEKVTLWKLMDVKERTGIELTESMAMW 1206
Query: 3583 PAASVSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGYDTD 3747
P A+VSG YF++PQS+YF VG++ QDQV DYA RK E ERWL+P LGY+ +
Sbjct: 1207 PGAAVSGWYFSHPQSQYFVVGRLAQDQVADYAKRKGWTLAEAERWLAPNLGYNPE 1261
>gi|34495658|ref|NP_899873.1| probable
5-methyltetrahydrofolate-homocysteine S-methyltransferase
[Chromobacterium violaceum ATCC 12472]
gi|34101513|gb|AAQ57882.1| probable
5-methyltetrahydrofolate-homocysteine S-methyltransferase
[Chromobacterium violaceum ATCC 12472]
Length = 1237
Score = 1278 bits (3308), Expect = 0.0
Identities = 663/1251 (52%), Positives = 881/1251 (69%), Gaps = 8/1251 (0%)
Frame = +1
Query: 13 SLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRPD 192
S+++ L++ RI+I+DG MGTMIQR + E D+RG D +KGNNDLL +TRPD
Sbjct: 8 SIYQHLSQ----RILILDGGMGTMIQRHQLTEADYRGARFADWRCDVKGNNDLLVLTRPD 63
Query: 193 IIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACD-DVGAA 369
+I IH+ YL+AGAD VETNTF+ T+IA ADY+ E LV EIN ++A + + C+ +
Sbjct: 64 VIAGIHQAYLDAGADIVETNTFNATSIAMADYQMEELVWEINREAARLVKELCEAETVKN 123
Query: 370 TGRRRYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVET 549
+ RY G +GPTNRT SISP V P +RNV+F +LV +Y + L+ GG D+LLVET
Sbjct: 124 PAKPRYCAGVLGPTNRTCSISPDVNDPGYRNVSFDQLVASYTEAIDGLVAGGADLLLVET 183
Query: 550 VFDSANAKAALFAIRTLFEDE-GVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKP 726
+FD+ NAKAA+FAI F++ + +P+ +SGTI D SGRTL+GQT EAF S
Sbjct: 184 IFDTLNAKAAVFAIHKYFDERPAIARLPIMISGTITDQSGRTLTGQTTEAFYNSLSHADA 243
Query: 727 MAVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFAR 906
+ GLNCALG +R +V+ M++ S +++ + NAGLPNA GGYD PE+M + +RE+A
Sbjct: 244 ASFGLNCALGPDLLRPYVEEMARVSSTYVSVHANAGLPNAFGGYDLEPEKMGEYVREWAE 303
Query: 907 DGLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVN 1086
GL+NI+GGCCGTTP+HI A+ +AV GI PR P K LSGLEP +G E FVN
Sbjct: 304 SGLINIVGGCCGTTPEHIAAIARAVDGIAPRALPSIE--AKCRLSGLEPFNIGDEDLFVN 361
Query: 1087 IGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLR 1266
+GER NV GSR F LI N +Y TA+DVAR QV++GAQ++D+NMD+G+LD AM +FL
Sbjct: 362 VGERTNVTGSRAFAKLILNGDYATALDVARQQVENGAQVIDINMDEGMLDAHAAMVRFLN 421
Query: 1267 LISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGA 1446
LI+SEPD+A++P+ IDSS +DVI AGL+ QGK +VNSISLKEG+EKF E+AR+I+RYGA
Sbjct: 422 LIASEPDIARVPIMIDSSKWDVIEAGLKCIQGKGIVNSISLKEGKEKFVEQARLIRRYGA 481
Query: 1447 AVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNY 1626
AV+VMAFDE+GQA K EIC+ SYRIL +EVGF P DIIFD NI +ATG++EH+ Y
Sbjct: 482 AVIVMAFDEKGQADTYARKIEICDHSYRILVDEVGFPPEDIIFDPNIFAVATGIDEHARY 541
Query: 1627 GMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVN 1806
G+ FIEA I+++LP A +SGGVSN+SFSFRG +REA+H+VFL++AI+ GM MGIVN
Sbjct: 542 GLDFIEATGWIKQHLPHAKISGGVSNVSFSFRGNNKVREAIHAVFLYHAIQRGMTMGIVN 601
Query: 1807 AGALPVYEDIDKPXXXXXXXXXFNRDP----EATEKLLVAAQEM-XXXXXXXXXXXXEWR 1971
AGAL VY+++D R P +ATE+L+ A++ WR
Sbjct: 602 AGALEVYDEVDPELRARIEDVVLMRQPKDGGDATERLIELAEKFKGEAAGEKKGEDLAWR 661
Query: 1972 SLTVEERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGK 2151
S VE+RL+ ALVKG+ F+V DTEE R +A RP++VIE PLMDGM VVG+LFGAGK
Sbjct: 662 SWPVEKRLEHALVKGITTFIVEDTEEVRLKSA---RPIHVIEGPLMDGMNVVGDLFGAGK 718
Query: 2152 MFLPQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDI 2331
MFLPQV+KSARVMK AVAHL PF+E E+ +GLA ++P +G +++ATVKGDVHDI
Sbjct: 719 MFLPQVVKSARVMKAAVAHLEPFIEEEK----IRLGLA--DAPAKGVIIMATVKGDVHDI 772
Query: 2332 GKNIVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEM 2511
GKNIV VVL CNN+KV+DLGVM PC+ I+ AA E KAD IGLSGLITPSL+EM +VAKE
Sbjct: 773 GKNIVGVVLRCNNYKVIDLGVMVPCQTILDAAREHKADIIGLSGLITPSLEEMSHVAKEK 832
Query: 2512 NRVGLNIPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQ 2691
R G +IPLLIGGATTSK HTAVKI+P Y HPVV+ DAS++V VCS+L +++DAF+
Sbjct: 833 QRQGFDIPLLIGGATTSKVHTAVKIAPHYQHPVVYVPDASRAVGVCSNLLSDTLKDAFVA 892
Query: 2692 DLNEDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNE 2871
+ + + R+ H A+ +R+ L R K KIDW + KP+++G R ++++ L+E
Sbjct: 893 ENLAEQQRAREGH-ANKANRKVVSLEAARANKEKIDWAGYVPPKPAWLGVRRFEHYPLSE 951
Query: 2872 LIPYIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVA 3051
+ YIDW PFF W+L G+ +P+I DD VG A+ +++DAQ LK+++DE L A
Sbjct: 952 IAQYIDWTPFFQSWELAGR-----FPRILDDEIVGESARALYEDAQVMLKRIVDENWLTA 1006
Query: 3052 NAVVSFLPAAS-EGDDMHVYDPETGNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGV 3228
NAV+ PAAS + DD+ + P+ G L T+ GLRQQ + + ++ L+D++ P +GV
Sbjct: 1007 NAVIGLFPAASVDDDDIEIRRPDNGASLMTWVGLRQQLPKTDGKANWALADYVAPKDSGV 1066
Query: 3229 PDDYLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWG 3408
DDY+G FA TAG+G E + K E +DDY++I++KALADRLAEA+AE +H VR WG
Sbjct: 1067 -DDYIGAFAVTAGIGIEPHVKRFEDANDDYSAILLKALADRLAEAFAELMHARVRREFWG 1125
Query: 3409 YSTNEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKNGIGLTEHLAMLPA 3588
Y+ +E + L+ +Y+GIRPA GYP+ PDHT K L+KLL+A G+ LTE AMLP
Sbjct: 1126 YAADEQIDNEGLIDEQYRGIRPAPGYPACPDHTVKTELFKLLDAPAIGMTLTEGYAMLPT 1185
Query: 3589 ASVSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGYD 3741
A+VSG YF++P S YF VGK+++DQV YA R+ V E+ ER L+P LGYD
Sbjct: 1186 AAVSGFYFSHPASRYFGVGKVEKDQVSSYAQRRGVTLEQAERDLAPNLGYD 1236
>gi|39936764|ref|NP_949040.1| methionine synthase [Rhodopseudomonas
palustris CGA009]
gi|39650620|emb|CAE29143.1| methionine synthase [Rhodopseudomonas
palustris CGA009]
Length = 1293
Score = 1277 bits (3305), Expect = 0.0
Identities = 679/1242 (54%), Positives = 853/1242 (68%), Gaps = 4/1242 (0%)
Frame = +1
Query: 25 ELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRPDIIYK 204
+L +A +RI+++DGAMGTMIQ+ ++E FRGE KD + L+GNNDLL +T+P I
Sbjct: 11 QLLALAAQRILVLDGAMGTMIQQLQLDEAAFRGERFKDFHRDLRGNNDLLILTQPQAIED 70
Query: 205 IHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAATGRRR 384
IH YL AGAD V TNTFS T+IAQADY L +E++ A +AR A V A G+ R
Sbjct: 71 IHAQYLRAGADIVATNTFSSTSIAQADYEMSELAYEMSRDGARLARNAAAKVEAEDGKPR 130
Query: 385 YVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVETVFDSA 564
+V GAIGPTNRT SISP V P +R VTF +L AY +Q L+ GG D+LL+ET+FD+
Sbjct: 131 FVAGAIGPTNRTASISPDVANPGYRAVTFDDLRIAYSEQINGLLDGGADILLLETIFDTL 190
Query: 565 NAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKPMAVGLN 744
NAKAAL+AI + E G+ ++PV +SGTI D SGR LSGQ EAF S + +P+ +G N
Sbjct: 191 NAKAALYAIAEITEARGI-DVPVMISGTITDKSGRLLSGQMPEAFWNSVRHARPITIGFN 249
Query: 745 CALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFARDGLVNI 924
CALGAKD+R + ++S+ +D+ + YPNAGLPN G YDE+PE MA ++ EFA GLVNI
Sbjct: 250 CALGAKDLRAHIADISRVADTLVCAYPNAGLPNEFGQYDESPEYMASLVGEFAEAGLVNI 309
Query: 925 IGGCCGTTPDHINAMYKAVQGITPRVPPQ-DPHAGKMLLSGLEPSIVGPETNFVNIGERC 1101
+GGCCGTTP HI A+ +AV PRV P DP ++ LSGLEP + + FVN+GER
Sbjct: 310 VGGCCGTTPAHIKAIAEAVAPHKPRVIPTIDP---RLRLSGLEPFELTKDIPFVNVGERT 366
Query: 1102 NVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLRLISSE 1281
NV GS +F LI +Y A+ VAR QV++GAQI+DVNMD+GLLD AM FL L+++E
Sbjct: 367 NVTGSAKFRKLITAGDYAAALQVARDQVENGAQIIDVNMDEGLLDSEAAMITFLNLVAAE 426
Query: 1282 PDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGAAVVVM 1461
PD+AK+PV +DSS F+VI AGL+ QGK VVNSISLKEGE+KF ARI +R+GAAVVVM
Sbjct: 427 PDIAKVPVMVDSSKFNVIEAGLKCLQGKPVVNSISLKEGEDKFLHEARIARRHGAAVVVM 486
Query: 1462 AFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNYGMYFI 1641
AFDE GQA K EIC R+Y IL VGF P DIIFD NI IATG+EEH+NYG+ FI
Sbjct: 487 AFDETGQADTYARKTEICARAYDILVNRVGFPPEDIIFDPNIFAIATGLEEHNNYGVDFI 546
Query: 1642 EAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVNAGALP 1821
EA R IR+NLP AH+SGGVSN+SFSFRG E +REAMHSVFL++AIKAGMDMGIVNAG +
Sbjct: 547 EATRWIRQNLPHAHISGGVSNLSFSFRGNEPVREAMHSVFLYHAIKAGMDMGIVNAGQMI 606
Query: 1822 VYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEMXXXXXXXXXXXXEWRSLTVEERLKF 2001
VY+DID NRDP A+E+LL A + WRS VE+RL
Sbjct: 607 VYDDIDPELRQVCEDVILNRDPGASERLLALADKYRGQGKQQKEQDLAWRSWPVEQRLSH 666
Query: 2002 ALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFLPQVIKSA 2181
ALV G+ +F+ DTEEAR AK RPL+VIE PLM GM VVG+LFG GKMFLPQV+KSA
Sbjct: 667 ALVHGITEFIELDTEEAR---AKAERPLHVIEGPLMAGMNVVGDLFGDGKMFLPQVVKSA 723
Query: 2182 RVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKNIVSVVLG 2361
RVMK+AVA+L+PFME E+ N+ G E G +V+ATVKGDVHDIGKNIV +VL
Sbjct: 724 RVMKQAVAYLMPFMEEEKARNL-AAGTDTGERATAGKIVLATVKGDVHDIGKNIVGIVLQ 782
Query: 2362 CNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRVGLNIPLL 2541
CNNF+V+DLGVM P II+ A E AD +GLSGLITPSLDEM ++A E+ R G NIPLL
Sbjct: 783 CNNFEVIDLGVMVPAAKIIETAKAENADIVGLSGLITPSLDEMSFLAGELQRSGFNIPLL 842
Query: 2542 IGGATTSKTHTAVKISPRYPH-PVVHCLDASKSVVVCSSLSDMSVRDAFLQDLNEDYEDV 2718
IGGATTS+ HTAVKI P YP VVH DAS++V V SSL A+ ++ DY +
Sbjct: 843 IGGATTSRVHTAVKIDPAYPSGSVVHVNDASRAVGVASSLLSKDRGAAYAAEVRADYAKI 902
Query: 2719 RQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIPYIDWKP 2898
H+ + D++ L R KIDW + VKPSF+G R + + L EL YIDW P
Sbjct: 903 SAAHHRAQADKKRLTLAAARANATKIDWAATSPVKPSFIGTRSFSGYSLAELAEYIDWTP 962
Query: 2899 FFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAVVSFLPA 3078
FF W+L G+ +P I DD+ VG A+ ++ DA+ L +++ E A A + F PA
Sbjct: 963 FFQAWELAGR-----FPAILDDSVVGEAARSLYADARKMLDRIVTENWFTAKATIGFWPA 1017
Query: 3079 ASEGDDMHVYDPET-GNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDDYLGLFA 3255
++GDD+ VY ET + T + LRQQ + + + LSDFI P+ + V DY+G F
Sbjct: 1018 NADGDDILVYADETRTTPIATLHTLRQQLDKREGRANAALSDFIAPVASSVA-DYIGGFV 1076
Query: 3256 CTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYSTNEDLTE 3435
TAG+G + + DDY+SIMVKALADRLAEA+AE +H VR WGY+ +E+L+
Sbjct: 1077 VTAGIGEDVIADKFKAERDDYSSIMVKALADRLAEAFAERMHARVRREFWGYAADENLSA 1136
Query: 3436 SDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKN-GIGLTEHLAMLPAASVSGLYF 3612
DL+ KYQGIRPA GYP+QPDHTEK TL++LL+AE + G+ LTE AM P +SVSGLYF
Sbjct: 1137 EDLILEKYQGIRPAPGYPAQPDHTEKATLFELLDAEASAGVTLTESFAMWPGSSVSGLYF 1196
Query: 3613 ANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGY 3738
++PQS YF VGKI++DQV DYAARK ERWL+P+L Y
Sbjct: 1197 SHPQSAYFGVGKIERDQVEDYAARKGWDVATAERWLAPVLNY 1238
>gi|27376529|ref|NP_768058.1| methionine synthase [Bradyrhizobium
japonicum USDA 110]
gi|27349670|dbj|BAC46683.1| methionine synthase [Bradyrhizobium
japonicum USDA 110]
Length = 1285
Score = 1275 bits (3299), Expect = 0.0
Identities = 674/1241 (54%), Positives = 859/1241 (68%), Gaps = 4/1241 (0%)
Frame = +1
Query: 28 LAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRPDIIYKI 207
L A ERI+++DGAMGTMIQ ++E FRGE K+ + L+GNNDLL +T+P I I
Sbjct: 12 LLNAAHERILVLDGAMGTMIQNLQLDEAAFRGERFKNFHRDLRGNNDLLILTQPQAIEDI 71
Query: 208 HKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAATGRRRY 387
H YL AGAD V TNTFS T+IAQADY +V+E+ + A +A A V A G+ R+
Sbjct: 72 HAAYLRAGADIVATNTFSTTSIAQADYDLTDIVYEMAREGARLAGNAARRVEAEDGKPRF 131
Query: 388 VCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVETVFDSAN 567
V GAIGPTNRT SISP V P +R VTF +L K+YG+Q ++ GGVD+LLVET+FD+ N
Sbjct: 132 VAGAIGPTNRTASISPDVSNPGYRAVTFDDLRKSYGEQINGMLDGGVDLLLVETIFDTLN 191
Query: 568 AKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKPMAVGLNC 747
AKAAL+AI + E G+ ++PV +SGTI D SGR LSGQ EAF S + KP+ +G NC
Sbjct: 192 AKAALYAIAEITEARGI-DVPVMVSGTITDKSGRLLSGQMPEAFWNSVRHAKPVTIGFNC 250
Query: 748 ALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFARDGLVNII 927
ALGA+D+R + ++ + +D+ + YPNAGLPN G YDETPE MA ++ EFARDGLVNI+
Sbjct: 251 ALGAEDLRAHIADIGRVADTLVCAYPNAGLPNEFGQYDETPEYMARLVGEFARDGLVNIV 310
Query: 928 GGCCGTTPDHINAMYKAVQGITPRVPPQ-DPHAGKMLLSGLEPSIVGPETNFVNIGERCN 1104
GGCCGTTPDHI A+ AV PR+ P+ +P ++ LSGLEP I+ FVN+GER N
Sbjct: 311 GGCCGTTPDHIAAIAAAVAPHKPRIVPEIEP---RLRLSGLEPFILTDAIPFVNVGERTN 367
Query: 1105 VAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLRLISSEP 1284
V GS RF LI +Y A+ VAR QV++GAQI+DVNMD+GLLD AM FL L+++EP
Sbjct: 368 VTGSARFRKLITAGDYTAALQVARDQVENGAQIIDVNMDEGLLDSEAAMVTFLNLVAAEP 427
Query: 1285 DVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGAAVVVMA 1464
D+A++PV +DSS F VI AGL+ QGK VVNSIS+KEGEEKF A+I +R+GAAVVVMA
Sbjct: 428 DIARVPVMVDSSKFSVIEAGLKCVQGKPVVNSISMKEGEEKFIHEAKIARRHGAAVVVMA 487
Query: 1465 FDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNYGMYFIE 1644
FDE GQA K EIC+R+Y IL VGF P DIIFD NI IATG+EEH+NYG+ FIE
Sbjct: 488 FDEVGQADTFARKTEICKRAYDILVNRVGFPPEDIIFDPNIFAIATGIEEHNNYGVDFIE 547
Query: 1645 AARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVNAGALPV 1824
A R IR+NLPGAH+SGGVSN+SFSFRG E +REAMHSVFL++AIKAGMDMGIVNAG + V
Sbjct: 548 ATRWIRQNLPGAHISGGVSNLSFSFRGNEPVREAMHSVFLYHAIKAGMDMGIVNAGQMIV 607
Query: 1825 YEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEMXXXXXXXXXXXXEWRSLTVEERLKFA 2004
Y+DID NRDP A+E+LL A++ WR V +RL +
Sbjct: 608 YDDIDPELRQVCEDVILNRDPGASERLLALAEKFRGNKTQTKEADLAWREWPVAKRLSHS 667
Query: 2005 LVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFLPQVIKSAR 2184
LV G+ +F+ DTEEAR+ ++ RPL+VIE PLM GM VVG+LFG GKMFLPQV+KSAR
Sbjct: 668 LVHGITEFIEVDTEEARKASS---RPLDVIEGPLMAGMNVVGDLFGDGKMFLPQVVKSAR 724
Query: 2185 VMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKNIVSVVLGC 2364
VMK+AVA L+PFME E+ N+ G+ + S G +V+ATVKGDVHDIGKNIV +VL C
Sbjct: 725 VMKQAVAWLMPFMEEEKARNLAN-GIGTEGSSSAGKIVLATVKGDVHDIGKNIVGIVLQC 783
Query: 2365 NNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRVGLNIPLLI 2544
NNF+V+DLGVM P I++ EKAD +GLSGLITPSLDEM + A E+ R GL +PLLI
Sbjct: 784 NNFEVIDLGVMVPAARIVETVKAEKADIVGLSGLITPSLDEMAFFAGELQREGLKLPLLI 843
Query: 2545 GGATTSKTHTAVKISPRY-PHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLNEDYEDVR 2721
GGATTS+ HTAVKI P Y PVVH DAS++V V S+L R A+ ++ +Y +
Sbjct: 844 GGATTSRVHTAVKIDPSYRAGPVVHVNDASRAVGVASALLSPEKRVAYAAEVRAEYAKIS 903
Query: 2722 QEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIPYIDWKPF 2901
H + D++ L R+ + +D+ VKP+F+G + + +DL EL+PYIDW PF
Sbjct: 904 DAHLRAQADKKRLKLADARKNRVPVDFAANKPVKPTFLGTKSFDAYDLAELVPYIDWTPF 963
Query: 2902 FDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAVVSFLPAA 3081
F W+L G+ +P I DDA VG A+ ++DDA+ L ++ EK A A V F PA
Sbjct: 964 FQTWELAGR-----FPAILDDAKVGEVARSLYDDARKMLDLIVKEKWFRARATVGFWPAN 1018
Query: 3082 SEGDDMHVYDPETGNK-LDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDDYLGLFAC 3258
+ GDD+ +Y E+ K + T + LRQQ + + + L+DFI P+ GVP DY+G F
Sbjct: 1019 AVGDDIALYADESRTKQIATLHTLRQQLEKREGRFNAALADFIAPVDTGVP-DYVGGFVV 1077
Query: 3259 TAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYSTNEDLTES 3438
TAG+G + + +DDY+SI+ KALADRLAEA+AE +H VR W Y+ +E L+
Sbjct: 1078 TAGIGEDAVADRFKMANDDYSSILCKALADRLAEAFAERMHARVRREFWAYAPDEALSCD 1137
Query: 3439 DLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKN-GIGLTEHLAMLPAASVSGLYFA 3615
DL+ KYQGIRPA GYP+QPDHTEK TL++LL+AE G+ LTE AM P +SVSGLYFA
Sbjct: 1138 DLILEKYQGIRPAPGYPAQPDHTEKATLFELLDAEATAGVKLTESFAMWPGSSVSGLYFA 1197
Query: 3616 NPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGY 3738
NP S YF VGKI++DQV DYAARK + E ERWL+P+L Y
Sbjct: 1198 NPASYYFGVGKIERDQVEDYAARKGMSITEAERWLAPVLNY 1238
>gi|21674670|ref|NP_662735.1| 5-methyltetrahydrofolate-homocysteine
methyltransferase [Chlorobium tepidum TLS]
gi|21647875|gb|AAM73077.1| 5-methyltetrahydrofolate-homocysteine
methyltransferase [Chlorobium tepidum TLS]
Length = 1228
Score = 1271 bits (3290), Expect = 0.0
Identities = 661/1244 (53%), Positives = 865/1244 (69%), Gaps = 4/1244 (0%)
Frame = +1
Query: 22 EELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRPDIIY 201
+ L + ++RI+++DGAMGTMIQR ++E+D+RGE HD PLKGNNDLL ITRPDII
Sbjct: 3 DNLYSLIEQRILVLDGAMGTMIQRHGLDEQDYRGERFASHDHPLKGNNDLLVITRPDIIR 62
Query: 202 KIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAAT-GR 378
IH +L+AGAD +ET TF+ I+Q+DY+ + L E+N +A +AR A D+ A T +
Sbjct: 63 SIHCDFLDAGADIIETCTFNANPISQSDYQLQDLTRELNVAAAKIARSAADEFTAKTPDK 122
Query: 379 RRYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVETVFD 558
R+V G+IGPTN+TLS+SP V P FR VTFQE+V Y Q L +GGVD+LLVETVFD
Sbjct: 123 PRFVAGSIGPTNKTLSLSPDVNNPGFRAVTFQEMVDNYTAQLEGLHEGGVDLLLVETVFD 182
Query: 559 SANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVS-TKQGKPMAV 735
+ N KAAL+AI G ++PV +SGT+VD SGRTLSGQT EAF +S + ++V
Sbjct: 183 TLNCKAALYAIEEYAVKTGW-QVPVMVSGTVVDASGRTLSGQTTEAFWISISHMPSLLSV 241
Query: 736 GLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFARDGL 915
GLNCALG+K MR F++ +S ++S++ YPNAGLPN G YD++PE MA + FA G
Sbjct: 242 GLNCALGSKQMRPFIEALSNIAESYVSVYPNAGLPNEFGEYDDSPEYMAAQIAGFAESGF 301
Query: 916 VNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVNIGE 1095
VNI+GGCCGTTP HI A+ +AV+ + PR P + H + LSGLEP +V T F+N+GE
Sbjct: 302 VNIVGGCCGTTPTHIRAIAEAVKTLPPRKRPANKHV--LRLSGLEPLVVDETTGFINVGE 359
Query: 1096 RCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLRLIS 1275
R NV GSR+F LIK NYD A+ +AR QV++GAQ++DVN+D+G+LD + +FL LI+
Sbjct: 360 RTNVTGSRKFARLIKEANYDEALSIARQQVENGAQVIDVNLDEGMLDSEKVIVEFLNLIA 419
Query: 1276 SEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGAAVV 1455
SEP++AK+PV IDSS + VI GL TQGK +VNSISLKEGEE FKERAR I +YGAA V
Sbjct: 420 SEPEIAKVPVMIDSSKWSVIENGLRCTQGKSIVNSISLKEGEELFKERARKIMQYGAAAV 479
Query: 1456 VMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNYGMY 1635
VMAFDEQGQA + EIC R+Y+ILTEEVGF P DIIFD N+LT+ATG++EH+NY +
Sbjct: 480 VMAFDEQGQADSLHRRIEICSRAYKILTEEVGFPPEDIIFDPNVLTVATGIDEHNNYALD 539
Query: 1636 FIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVNAGA 1815
FIE+ R I++NLP A VSGG+SN+SFSFRG E +REAMH+ FL++AI AG+DMGIVNA
Sbjct: 540 FIESVRWIKQNLPHAKVSGGISNVSFSFRGNEPVREAMHTAFLYHAIHAGLDMGIVNAAQ 599
Query: 1816 LPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEMXXXXXXXXXXXXEWRSLTVEERL 1995
L +YE+ID NR +ATE+L+ A+ + EWR+ VEERL
Sbjct: 600 LGIYEEIDPELLVYVEDVLLNRRDDATERLVAFAETIRDGGEKAEAKNAEWRNAPVEERL 659
Query: 1996 KFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFLPQVIK 2175
K ALVKG+ ++ DTEEARQ YP PL VIE PLM+GM VG+LF GKMFLPQV+K
Sbjct: 660 KHALVKGIVDYIDEDTEEARQ---LYPSPLEVIEGPLMNGMNHVGDLFAEGKMFLPQVVK 716
Query: 2176 SARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKNIVSVV 2355
SARVMK++VA L+P++E E+ N +T A+ V++ATVKGDVHDIGKNIVSVV
Sbjct: 717 SARVMKRSVAALIPYIEEEKSKNCDTSAKAK--------VLLATVKGDVHDIGKNIVSVV 768
Query: 2356 LGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRVGLNIP 2535
L CNNF V+D+GVM PC+ I++A E K D +GLSGLITPSL+EM +VAKEM R+G+NIP
Sbjct: 769 LACNNFDVIDIGVMMPCDKILEALAEHKPDVLGLSGLITPSLEEMAHVAKEMERLGMNIP 828
Query: 2536 LLIGGATTSKTHTAVKISPRYPH-PVVHCLDASKSVVVCSSLSDMSVRDAFLQDLNEDYE 2712
L+IGGATTSK HTAVK++P YP VVH LDAS+SV V S+L + + RD+++ L ++ E
Sbjct: 829 LIIGGATTSKVHTAVKLAPCYPSGAVVHVLDASRSVPVVSNLCNPAQRDSYIAALKDEQE 888
Query: 2713 DVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIPYIDW 2892
+R+ H + +++ L+ R+ + IDW+ T KP+ G ++ + L PYIDW
Sbjct: 889 AMRKSHAERMAAKKYVSLDAARDNRLTIDWEAETIDKPAQTGVTVLEDVTVGALRPYIDW 948
Query: 2893 KPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAVVSFL 3072
PFF W+L G YP+I +D VG EA K+F+DA L ++ EK+L V
Sbjct: 949 APFFWSWELHG-----VYPQILEDEKVGEEATKLFNDATALLDRIDSEKLLGIKGVAGIF 1003
Query: 3073 PAASEGDDMHVYDPETGNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDDYLGLF 3252
PA S GDD+ VY + + + T +Q G +H + + L+DF+ P ++GV +D++G F
Sbjct: 1004 PANSIGDDIFVYADDERSIIRTVLHTLRQQGEKHGEANLALADFVAPRESGV-NDWIGCF 1062
Query: 3253 ACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYSTNEDLT 3432
TAGLG + +DDY IM +ALADRLAEA+AE LH++VR LWGY+ E L
Sbjct: 1063 TVTAGLGIQNLLDEFTAENDDYHRIMTQALADRLAEAFAEMLHEKVRRELWGYAPGEILG 1122
Query: 3433 ESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAE-KNGIGLTEHLAMLPAASVSGLY 3609
+L++ KY+GIRPA GYP+ PDHTEK ++ LL AE G+ LTE AM PAASV GLY
Sbjct: 1123 NEELIAEKYRGIRPAPGYPACPDHTEKAIIFDLLNAEAATGVTLTETFAMNPAASVCGLY 1182
Query: 3610 FANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGYD 3741
FANP S+YF +GKI +DQV DYA RK + E E+WL+P L YD
Sbjct: 1183 FANPASKYFVLGKIGKDQVEDYANRKGLEVAEAEKWLAPSLNYD 1226
>gi|15597040|ref|NP_250534.1| methionine synthase [Pseudomonas
aeruginosa PA01]
gi|11350596|pir||E83415 methionine synthase PA1843 [imported] -
Pseudomonas aeruginosa (strain PAO1)
gi|9947830|gb|AAG05232.1| methionine synthase [Pseudomonas aeruginosa
PAO1]
Length = 1234
Score = 1271 bits (3290), Expect = 0.0
Identities = 676/1249 (54%), Positives = 859/1249 (68%), Gaps = 4/1249 (0%)
Frame = +1
Query: 7 RSSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITR 186
RS+ + L +ERI+I+DG MGTMIQ +EE D+RGE D +KGNNDLL ++R
Sbjct: 8 RSARLQALQHALRERILILDGGMGTMIQSYKLEEADYRGERFADWPSDVKGNNDLLLLSR 67
Query: 187 PDIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGA 366
PD+I I K YL+AGAD +ETNTF+ T ++QADY + L +E+N + A +AR+ D A
Sbjct: 68 PDVIQAIEKAYLDAGADILETNTFNATQVSQADYGMQSLAYELNVEGARLARQVADAKTA 127
Query: 367 AT-GRRRYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLV 543
T + R+V G +GPT+RT SISP V P +RNVTF ELV+ Y + R LI+GG D++L+
Sbjct: 128 ETPDKPRFVAGVLGPTSRTCSISPDVNNPGYRNVTFDELVENYVEATRGLIEGGADLILI 187
Query: 544 ETVFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGK 723
ET+FD+ NAKAA+FA++ +FE+ GV E+P+ +SGTI D SGRTLSGQT EAF S + +
Sbjct: 188 ETIFDTLNAKAAIFAVQGVFEELGV-ELPIMISGTITDASGRTLSGQTTEAFWNSVRHAR 246
Query: 724 PMAVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFA 903
P++VGLNCALGAK++R +++ +S +D+ + +PNAGLPNA G YDE+P EMA V+ EFA
Sbjct: 247 PISVGLNCALGAKELRPYIEELSTKADTHVSAHPNAGLPNAFGEYDESPAEMAVVVEEFA 306
Query: 904 RDGLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFV 1083
G +NI+GGCCGTTP HI A+ KAV PR P+ P A + LSGLEP + + FV
Sbjct: 307 AAGFLNIVGGCCGTTPAHIEAIAKAVAKYPPRAIPEIPRACR--LSGLEPFTIDRSSLFV 364
Query: 1084 NIGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFL 1263
N+GER N+ GS +F LI+ ENY A++VA+ QV++GAQ++D+NMD+G+LD AM FL
Sbjct: 365 NVGERTNITGSAKFARLIREENYAEALEVAQQQVEAGAQVIDINMDEGMLDSKAAMVTFL 424
Query: 1264 RLISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYG 1443
LI+SEPD++++P+ IDSS ++VI AGL+ QGK +VNSIS+KEG E FK AR+ KRYG
Sbjct: 425 NLIASEPDISRVPIMIDSSKWEVIEAGLKCIQGKGIVNSISMKEGVEAFKHHARLCKRYG 484
Query: 1444 AAVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSN 1623
AAVVVMAFDE GQA K EIC+RSY IL +EVGF P DIIFDANI IATG+EEH+N
Sbjct: 485 AAVVVMAFDEDGQADTQARKEEICKRSYDILVDEVGFPPEDIIFDANIFAIATGIEEHNN 544
Query: 1624 YGMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIV 1803
Y + FI A IR+NLP A SGGVSN+SFSFRG +REA+HSVFL+YAI+ G+ MGIV
Sbjct: 545 YAVDFINACAYIRDNLPYALSSGGVSNVSFSFRGNNPVREAIHSVFLYYAIRNGLTMGIV 604
Query: 1804 NAGALPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEMXXXXXXXXXXXXEWRSLTV 1983
NAG L +Y++I K NR PEATE LL A + EWRS +V
Sbjct: 605 NAGQLEIYDEIPKALRDRVEDVVLNRTPEATEALLAIADDYKGGGAVKEAEDEEWRSYSV 664
Query: 1984 EERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFLP 2163
E+RL+ ALVKG+ ++V DTEE RQ A RP+ VIE PLM GM VVG+LFGAGKMFLP
Sbjct: 665 EKRLEHALVKGITTWIVEDTEECRQQCA---RPIEVIEGPLMSGMNVVGDLFGAGKMFLP 721
Query: 2164 QVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKNI 2343
QV+KSARVMK+AVAHL+PF+E E+ D+ +G +++ATVKGDVHDIGKNI
Sbjct: 722 QVVKSARVMKQAVAHLIPFIEAEK----------GDKPEAKGKILMATVKGDVHDIGKNI 771
Query: 2344 VSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRVG 2523
V VVLGCN + VVDLGVM P E I++ AI EK D IGLSGLITPSLDEMV+VAKEM R
Sbjct: 772 VGVVLGCNGYDVVDLGVMVPAEKILQTAIAEKCDIIGLSGLITPSLDEMVHVAKEMQRQN 831
Query: 2524 LNIPLLIGGATTSKTHTAVKISPRYPH-PVVHCLDASKSVVVCSSLSDMSVRDAFLQDLN 2700
+PL+IGGATTSK HTAVKI P+Y + VV+ DAS++V V +SL ++ ++
Sbjct: 832 FQLPLMIGGATTSKAHTAVKIDPQYSNDAVVYVTDASRAVGVATSLLSKELKADYVARTR 891
Query: 2701 EDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIP 2880
DY VR+ + K DW + A PSF G R DL L
Sbjct: 892 ADYAVVRERTANRSARTERLSYEQAIANKPAFDWAGYQAPTPSFTGVRVLDEIDLAVLAE 951
Query: 2881 YIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAV 3060
YIDW PFF W L GK YP+I D VG A +F+DAQ LKKLIDEK++ A AV
Sbjct: 952 YIDWTPFFISWDLAGK-----YPRILTDEVVGEAATSLFNDAQAMLKKLIDEKLIKARAV 1006
Query: 3061 VSFLPAAS-EGDDMHVYDPETGNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDD 3237
F PA E DD+ VY + G L T + LRQQ+ + +P+ L+DF+ P ++GV D
Sbjct: 1007 FGFWPANQVEHDDLEVYGAD-GETLATLHHLRQQTIKPDGKPNLSLADFVAPKESGV-RD 1064
Query: 3238 YLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYST 3417
Y+G F TAG+GAEE K E DDY SIMVKALADRLAEA AE+LH+ VR WGY+
Sbjct: 1065 YIGGFITTAGIGAEEVAKAYEAKGDDYNSIMVKALADRLAEACAEWLHERVRKEYWGYAR 1124
Query: 3418 NEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAE-KNGIGLTEHLAMLPAAS 3594
+E L L+ +Y GIRPA GYP+ PDHTEK TL++LL+ + +G+ LTEH AM PAA+
Sbjct: 1125 DEHLDNEALIKEQYVGIRPAPGYPACPDHTEKGTLFELLDPQGLSGVSLTEHYAMFPAAA 1184
Query: 3595 VSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGYD 3741
VSG YFA+PQ++YFAVGKID+DQV Y+ RK ERWL+P LGYD
Sbjct: 1185 VSGWYFAHPQAQYFAVGKIDKDQVERYSQRKGQEASVSERWLAPNLGYD 1233
>gi|23105437|ref|ZP_00091893.1| COG1410: Methionine synthase I,
cobalamin-binding domain [Azotobacter vinelandii]
Length = 1278
Score = 1271 bits (3289), Expect = 0.0
Identities = 667/1249 (53%), Positives = 866/1249 (68%), Gaps = 4/1249 (0%)
Frame = +1
Query: 7 RSSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITR 186
R++ + L + KERI+I+DG MGTMIQ +EE D+RG D + +KGNNDLL +TR
Sbjct: 49 RAARLQALQQALKERILILDGGMGTMIQSYKLEESDYRGTRFADWPQDVKGNNDLLLLTR 108
Query: 187 PDIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGA 366
PD+I I + YL+AGAD +ETNTF+ T ++QADY E LV+E+N + A +AR+ D A
Sbjct: 109 PDVIQAIEQAYLDAGADILETNTFNATRVSQADYGMEELVYELNVEGARLARQVADAKSA 168
Query: 367 AT-GRRRYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLV 543
R R+V G IGPT+RT SISP V P +RNVTF ELV Y + R LI+GG D++L+
Sbjct: 169 ENPARPRFVAGVIGPTSRTCSISPDVNNPGYRNVTFDELVDNYTEATRGLIEGGADLILI 228
Query: 544 ETVFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGK 723
ET+FD+ NAKAA++A++ +FE++GV +P+ +SGTI D SGRTLSGQT EAF S + +
Sbjct: 229 ETIFDTLNAKAAIYAVQQVFEEDGV-SLPIMISGTITDASGRTLSGQTTEAFWNSVRHAE 287
Query: 724 PMAVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFA 903
P++VGLNCALGAKD+R +++ ++ +D+ + +PNAGLPNA G YDETP +MA+V+ EFA
Sbjct: 288 PISVGLNCALGAKDLRPYLEELATKADTHVSAHPNAGLPNAFGEYDETPAQMAEVIEEFA 347
Query: 904 RDGLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFV 1083
G +NI+GGCCGTTP HI A+ +AV PR P+ P A + LSGLEP + ++ FV
Sbjct: 348 AAGFLNIVGGCCGTTPAHIRAIAEAVAKYPPRAIPEIPRACR--LSGLEPFTIDRDSLFV 405
Query: 1084 NIGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFL 1263
N+GER N+ GS RF LI+ ENY A+DVAR QV++GAQ++D+NMD+G+LD AM FL
Sbjct: 406 NVGERTNITGSARFARLIREENYAEALDVARQQVEAGAQVIDINMDEGMLDSKAAMVTFL 465
Query: 1264 RLISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYG 1443
LI+SEPD++++P+ IDSS ++VI AGL+ QGK +VNSIS+KEG E FK A + KRYG
Sbjct: 466 NLIASEPDISRVPIMIDSSKWEVIEAGLKCIQGKGIVNSISMKEGVEPFKHHAHLCKRYG 525
Query: 1444 AAVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSN 1623
AAVVVMAFDE GQA K EIC+RSY IL +EVGF P DIIFD NI +ATG+EEH+N
Sbjct: 526 AAVVVMAFDEAGQADTAARKREICQRSYDILVDEVGFPPEDIIFDPNIFAVATGIEEHNN 585
Query: 1624 YGMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIV 1803
Y + FIEA IR+NLP A SGGVSN+SFSFRG +REA+HSVFL++AI+ G+ MGIV
Sbjct: 586 YAVDFIEACAYIRDNLPYALSSGGVSNVSFSFRGNNPVREAIHSVFLYHAIRNGLTMGIV 645
Query: 1804 NAGALPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEMXXXXXXXXXXXXEWRSLTV 1983
NAG L +Y++I + NR P ATE LL A EWR V
Sbjct: 646 NAGQLEIYDEIPEELRDKVEDVVLNRHPGATEALLAIADRYKGDGTVKEAETEEWRGYPV 705
Query: 1984 EERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFLP 2163
+RL+ ALVKG+ ++V DTEE R+ A RP+ VIE PLM GM VVG+LFGAGKMFLP
Sbjct: 706 GKRLEHALVKGITTWIVEDTEECRRQCA---RPIEVIEGPLMSGMNVVGDLFGAGKMFLP 762
Query: 2164 QVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKNI 2343
QV+KSARVMK+AVAHL+PF+E E+ D+ +G +++ATVKGDVHDIGKNI
Sbjct: 763 QVVKSARVMKQAVAHLIPFIEAEK----------GDKPEAKGKILMATVKGDVHDIGKNI 812
Query: 2344 VSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRVG 2523
V VVLGCN + VVDLGVM P E I++ A EEK D IGLSGLITPSLDEMV+VA+EM R G
Sbjct: 813 VGVVLGCNGYDVVDLGVMVPAEKILQTAREEKCDIIGLSGLITPSLDEMVHVAREMQRQG 872
Query: 2524 LNIPLLIGGATTSKTHTAVKISPRYPH-PVVHCLDASKSVVVCSSLSDMSVRDAFLQDLN 2700
+PL+IGGATTSK HTAVKI P+Y + VV+ DAS++V V +SL ++ ++ +
Sbjct: 873 FALPLMIGGATTSKAHTAVKIEPQYANDAVVYVTDASRAVGVATSLLSKELKPDYVAKIR 932
Query: 2701 EDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIP 2880
DY +VR+ + K ++DW + +P+F G + ++ DL L
Sbjct: 933 TDYAEVRERTANRGARAERLSYAQAVANKPQLDWTGYRPPQPAFTGVKVLEDIDLAVLAG 992
Query: 2881 YIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAV 3060
YIDW PFF W L GK YP+I +DA VG A +F DAQ LKKLIDEK++ A AV
Sbjct: 993 YIDWTPFFMSWDLAGK-----YPRILEDAVVGEAASALFKDAQGMLKKLIDEKLIRAKAV 1047
Query: 3061 VSFLPAAS-EGDDMHVYDPETGNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDD 3237
F PA DD+ VY + G L T + LRQQ+ + +P+ L+DF+ P +GV D
Sbjct: 1048 FGFWPANQVRDDDLEVYG-DDGRPLATLHHLRQQAAKPDGKPNQSLADFVAPKDSGV-TD 1105
Query: 3238 YLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYST 3417
Y+G F TAG+GAEE K + DDY+SIMVKALADRLAEA AE+LH+ VR WGY+
Sbjct: 1106 YVGGFIVTAGIGAEELAKAYQDQGDDYSSIMVKALADRLAEACAEWLHERVRKEYWGYAP 1165
Query: 3418 NEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAE-KNGIGLTEHLAMLPAAS 3594
NE L+ +L+ +Y+GIRPA GYP+ PDHTEK TL++LL+ + +G+ LTEH AM PAA+
Sbjct: 1166 NERLSNEELIKEQYKGIRPAPGYPACPDHTEKGTLFRLLDPQGTSGVTLTEHYAMFPAAA 1225
Query: 3595 VSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGYD 3741
VSG YFA+P+++YFAVGKID+DQV Y+ RK EE ERWL P LGY+
Sbjct: 1226 VSGWYFAHPEAKYFAVGKIDRDQVESYSQRKGQSVEESERWLMPNLGYE 1274
>gi|27364808|ref|NP_760336.1| Methionine synthase I [Vibrio vulnificus
CMCP6]
gi|27360953|gb|AAO09863.1| Methionine synthase I [Vibrio vulnificus
CMCP6]
Length = 1226
Score = 1270 bits (3286), Expect = 0.0
Identities = 654/1233 (53%), Positives = 861/1233 (69%), Gaps = 5/1233 (0%)
Frame = +1
Query: 43 KERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRPDIIYKIHKLYL 222
K+RI++IDG MGTMIQ ++E+D+RGE D LKGNNDLL +T+P +I +IH YL
Sbjct: 14 KQRILLIDGGMGTMIQGYKLQEQDYRGERFADWHSDLKGNNDLLVLTQPQLIKEIHHAYL 73
Query: 223 EAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAAT-GRRRYVCGA 399
EAGAD +ETNTF+ TTIA ADY E L EIN+ +A +AR A D+ A + RYV G
Sbjct: 74 EAGADILETNTFNATTIAMADYDMESLSEEINFAAARLAREAADEWTAQNPAKPRYVAGV 133
Query: 400 IGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVETVFDSANAKAA 579
+GPTNRT SISP V P +RNV+F ELV+AY + R+LI+GG D++L+ET+FD+ NAKA
Sbjct: 134 LGPTNRTCSISPDVNDPGYRNVSFDELVEAYSESTRALIRGGSDLILIETIFDTLNAKAC 193
Query: 580 LFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKPMAVGLNCALGA 759
FA+ ++FE+ G +PV +SGTI D SGRTLSGQT EAF S + +P++ GLNCALG
Sbjct: 194 AFAVDSVFEELGFA-LPVMISGTITDASGRTLSGQTTEAFYNSLRHVRPISFGLNCALGP 252
Query: 760 KDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFARDGLVNIIGGCC 939
++R +V+ +S+ S++F+ +PNAGLPNA G YD +PEEMA+ ++E+A+ G +N+IGGCC
Sbjct: 253 DELRPYVEELSRISETFVSTHPNAGLPNAFGEYDLSPEEMAEHVKEWAQSGFLNLIGGCC 312
Query: 940 GTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVNIGERCNVAGSR 1119
GTTP+HI M AV+G++PRV P+ P A + LSGLEP + +T FVN+GER NV GS
Sbjct: 313 GTTPEHIRHMAMAVEGVSPRVLPEIPVACR--LSGLEPLTIAKDTLFVNVGERTNVTGSA 370
Query: 1120 RFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLRLISSEPDVAKI 1299
RF LIK E YD A+DVAR QV++GAQI+D+NMD+G+LD M +FL L +SEP+++K+
Sbjct: 371 RFKRLIKEELYDEALDVAREQVENGAQIIDINMDEGMLDAEACMVRFLNLCASEPEISKV 430
Query: 1300 PVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGAAVVVMAFDEQG 1479
P+ +DSS ++VI AGL+ QGK +VNSISLKEG+EKF E+A++I+RYGAAV+VMAFDE G
Sbjct: 431 PIMVDSSKWEVIEAGLKCIQGKGIVNSISLKEGKEKFVEQAKLIRRYGAAVIVMAFDEVG 490
Query: 1480 QAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNYGMYFIEAARMI 1659
QA + K EIC ++YRIL +EVGF P D+IFD NI +ATG++EH+NY + FIEA I
Sbjct: 491 QADTRERKLEICTKAYRILVDEVGFPPEDVIFDPNIFAVATGIDEHNNYAVDFIEAVADI 550
Query: 1660 RENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVNAGALPVYEDID 1839
+ +LP A +SGGVSN+SFSFRG +REA+H+VFL++ K GMDMGIVNAG L +Y+++
Sbjct: 551 KRDLPHAMISGGVSNVSFSFRGNNYVREAIHAVFLYHCFKNGMDMGIVNAGQLEIYDNVP 610
Query: 1840 KPXXXXXXXXXFNRDPEATEKLLVAAQEM--XXXXXXXXXXXXEWRSLTVEERLKFALVK 2013
+ NR +ATE+LL A+E EWR+ +VE+RL+ ALVK
Sbjct: 611 EKLREAVEDVVLNRRDDATERLLEIAEEYRENAVGKQEDASALEWRTWSVEKRLEHALVK 670
Query: 2014 GVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFLPQVIKSARVMK 2193
G+ +F+V DTEEAR N +K PL VIE PLMDGM VVG+LFG GKMFLPQV+KSARVMK
Sbjct: 671 GITEFIVEDTEEARLNASK---PLEVIEGPLMDGMNVVGDLFGEGKMFLPQVVKSARVMK 727
Query: 2194 KAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKNIVSVVLGCNNF 2373
+AVAHL PF+ +QA G +++ATVKGDVHDIGKNIV VVL CNN+
Sbjct: 728 QAVAHLEPFINASKQAGSS-----------NGKILLATVKGDVHDIGKNIVGVVLQCNNY 776
Query: 2374 KVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRVGLNIPLLIGGA 2553
+++DLGVM PCE I+K A E++ D IGLSGLITPSLDEMV+VAKEM R+G ++PLLIGGA
Sbjct: 777 EIIDLGVMVPCEQILKVAKEQQVDIIGLSGLITPSLDEMVHVAKEMERLGFDLPLLIGGA 836
Query: 2554 TTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLNEDYEDVRQEHY 2733
TTSK HTAVKI Y HPVV+ +AS++V VC+SL +R AF++ L DYE VR +H
Sbjct: 837 TTSKAHTAVKIEQNYSHPVVYVNNASRAVGVCTSLLSDELRPAFVERLQADYELVRDQHN 896
Query: 2734 ASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIPYIDWKPFFDVW 2913
+ L R K IDW +T PS G + +FD+ L YIDW PFF W
Sbjct: 897 RKKPRTKPVTLEAARANKVAIDWQSYTPPAPSQPGVHVFDDFDVATLRQYIDWTPFFLTW 956
Query: 2914 QLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAVVSFLPAASEGD 3093
L GKYP IF+ +VG EAK++F DA WL ++ E +L A + PAAS GD
Sbjct: 957 SLVGKYPT-----IFEHEEVGEEAKRLFGDANEWLDRIEQEGLLKARGMCGLFPAASVGD 1011
Query: 3094 DMHVYDPETGNKL-DTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDDYLGLFACTAGL 3270
D+ VY E+ + + LRQQ+ + ++CLSD++ P ++G D++G FA T G+
Sbjct: 1012 DIEVYTDESRTHVAKVLHNLRQQTEKPKG-ANYCLSDYVAPKESG-KKDWIGAFAVTGGV 1069
Query: 3271 GAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYSTNEDLTESDLLS 3450
E + DDY +IM++A+ADRLAEA+AEYLH+ VR +WGY+ +E+L+ +L+
Sbjct: 1070 NERELADQFKAQGDDYNAIMIQAVADRLAEAFAEYLHERVRKEIWGYAADENLSNEELIR 1129
Query: 3451 IKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKN-GIGLTEHLAMLPAASVSGLYFANPQS 3627
KYQGIRPA GYP+ P+HTEK LW+LL E+ G+ LT AM P ASVSG YF++P S
Sbjct: 1130 EKYQGIRPAPGYPACPEHTEKGPLWELLNVEETIGMSLTSSYAMWPGASVSGWYFSHPDS 1189
Query: 3628 EYFAVGKIDQDQVIDYAARKNVPKEEVERWLSP 3726
YFA+ +I QDQV YA RK E E+WL P
Sbjct: 1190 RYFAIAQIQQDQVESYAERKGWDLLEAEKWLGP 1222
>gi|24217169|ref|NP_714652.1| B12-dependent
homocysteine-N5-methyltetrahydrofolate transmethylase
[Leptospira interrogans serovar Lai str. 56601]
gi|45655668|ref|YP_003477.1| methionine synthase; B12-dependent
homocysteine-N5-methyltetrahydrofolate transmethylase
[Leptospira interrogans serovar Copenhageni str. Fiocruz
L1-130]
gi|24202211|gb|AAN51667.1| B12-dependent
homocysteine-N5-methyltetrahydrofolate transmethylase
[Leptospira interrogans serovar lai str. 56601]
gi|45602639|gb|AAS72114.1| methionine synthase; B12-dependent
homocysteine-N5-methyltetrahydrofolate transmethylase
[Leptospira interrogans serovar Copenhageni str. Fiocruz
L1-130]
Length = 1247
Score = 1270 bits (3286), Expect = 0.0
Identities = 667/1246 (53%), Positives = 864/1246 (68%), Gaps = 6/1246 (0%)
Frame = +1
Query: 22 EELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRPDIIY 201
+EL + +++I++IDGAMGTMIQR ++EEDFRGEILK+H PLKGNN+LL +TRPD+I
Sbjct: 14 KELLSLLEKQILVIDGAMGTMIQRFSLQEEDFRGEILKNHLHPLKGNNELLCLTRPDVIE 73
Query: 202 KIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAATGRR 381
IH +LEAGA+ VETNTFS I+Q DY+ E LV ++N + + AR A
Sbjct: 74 SIHLKFLEAGANIVETNTFSSNQISQGDYKTEFLVADLNKAAVVCARNAITKFQKTNPDH 133
Query: 382 R-YVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVETVFD 558
+ GAIGPT +T ++SP V P FR VTF +LV + +QAR+L++ GVD+LL ET D
Sbjct: 134 PCLIAGAIGPTTKTATLSPDVNNPAFRAVTFDDLVATFYEQARALVESGVDLLLPETNID 193
Query: 559 SANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKPMAVG 738
+ N KAA+FAI +FED V +PV LS TI D SGRTLSGQT EAF S P++VG
Sbjct: 194 TLNLKAAIFAIEQVFEDLQV-RIPVCLSVTITDASGRTLSGQTVEAFYNSIAHCNPLSVG 252
Query: 739 LNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFARDGLV 918
+NCALGA +MR +++ +++ S +I CYPNAGLPNA GGYD+TPEE ++EFA G +
Sbjct: 253 INCALGADEMRPYIEELARVSPCYISCYPNAGLPNAFGGYDQTPEEFGKYIQEFASSGWL 312
Query: 919 NIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVNIGER 1098
NI GGCCGTTP+HI A KAV+G PR+ P+ + LSGLEP + P+ F+ +GER
Sbjct: 313 NIAGGCCGTTPEHIEAAAKAVRGKKPRILPKIEEVTR--LSGLEPLNITPDKGFLLVGER 370
Query: 1099 CNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLRLISS 1278
NV GS +F LI N++ A+ VA QV++GA I+D+N D+ LLDG +M FL LI+
Sbjct: 371 TNVTGSPKFKKLIIEGNFEEAVSVALQQVEAGANIIDINFDEALLDGEASMRHFLNLIAG 430
Query: 1279 EPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGAAVVV 1458
EPD+AK+P IDSS + V+ GL+ QGK ++NSISLKEGE+KF E A+ I+RYGA+ +V
Sbjct: 431 EPDIAKVPFMIDSSKWSVLEEGLKCIQGKPILNSISLKEGEDKFLEYAKKIQRYGASAIV 490
Query: 1459 MAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNYGMYF 1638
MAFDEQGQAA + K IC+R+Y +L + F+P DIIFD NILT+ATG+EEH+NY + F
Sbjct: 491 MAFDEQGQAATKEDKVRICKRAYDLLVTKANFSPTDIIFDPNILTVATGIEEHNNYAVDF 550
Query: 1639 IEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVNAGAL 1818
IEA R I++ PGA VSGG+SN+SFSFRG +REAMHSVFL+YAI+AGMDM IVNAG L
Sbjct: 551 IEAVREIKKLCPGAKVSGGLSNVSFSFRGNNPVREAMHSVFLYYAIQAGMDMAIVNAGML 610
Query: 1819 PVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEMXXXXXXXXXXXXEWRSLT-VEERL 1995
VYE+I K NR P+ATE+L+ A+ + WR T VEERL
Sbjct: 611 AVYEEIPKDLLEYVEDVILNRRPDATERLVEFAESVKSTGDKTEKKEEAWREGTSVEERL 670
Query: 1996 KFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFLPQVIK 2175
ALVKG+ +++ DTEEAR KY RPL VIE PLMDGM +VGELFGAGKMFLPQV+K
Sbjct: 671 SHALVKGIVEYIDQDTEEAR---LKYGRPLTVIEGPLMDGMKIVGELFGAGKMFLPQVVK 727
Query: 2176 SARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKNIVSVV 2355
SARVMKK+VA+LLPFME E+ + S + +IATVKGDVHDIGKNIV VV
Sbjct: 728 SARVMKKSVAYLLPFMEEEKN--------QIENSTARPKFLIATVKGDVHDIGKNIVGVV 779
Query: 2356 LGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRVGLNIP 2535
L CNN++V+DLGVM P + I++ A + IGLSGLITPSLDEMV+VA EM R+GL IP
Sbjct: 780 LACNNYEVIDLGVMVPPDKILEEAKKHNVSIIGLSGLITPSLDEMVHVASEMKRIGLEIP 839
Query: 2536 LLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLNEDYED 2715
LLIGGATTS HTAVKI+P Y HPVVH +DAS+ V V + L + +A+ Q + ED +
Sbjct: 840 LLIGGATTSSAHTAVKIAPVYDHPVVHVVDASRVVNVVNQLLHPDLHEAYSQKVKEDQKI 899
Query: 2716 VRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREY-QNFDLNELIPYIDW 2892
R+ ++ + +R+ L + RE + IDW KPSF+G + + + L L+P+IDW
Sbjct: 900 ARENYFNTRAERKLISLEQARENRDPIDWSTTVIDKPSFIGIKVFDEEISLETLVPFIDW 959
Query: 2893 KPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAVVSFL 3072
PFF W+L+G+ YP I + G +A+++F DAQ +K +I K+ V+
Sbjct: 960 TPFFTAWELKGR-----YPAILESETTGKQARELFADAQKLMKTIITGKLFRTKGVIGIF 1014
Query: 3073 PAASEGDDMHVYDPETGNKLDT-FYGLRQQSGREHD-QPHFCLSDFIKPLKNGVPDDYLG 3246
PA S DD+ VY+ E +KL T F+ LRQQ ++ + +P++CL+D++ P ++G DY+G
Sbjct: 1015 PANSVRDDIFVYEDENCSKLLTVFHTLRQQIQKQDETEPNYCLADYVAPKESG-RVDYIG 1073
Query: 3247 LFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYSTNED 3426
FA TAG G EE+ K E N DDY SIM KAL DR AEA+AEY+H +VR WGY NE+
Sbjct: 1074 GFAVTAGHGVEEFAKEFENNQDDYNSIMAKALGDRFAEAFAEYMHYKVRKEYWGYDKNEN 1133
Query: 3427 LTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKN-GIGLTEHLAMLPAASVSG 3603
L+ DL+ KY+GIRPA GYP+ PDHTEKR L+ LL+ EKN GI LTEH AM PA+SVSG
Sbjct: 1134 LSPEDLIREKYRGIRPAAGYPASPDHTEKRALFDLLQVEKNTGITLTEHFAMWPASSVSG 1193
Query: 3604 LYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGYD 3741
LYFA+P+S+YFAV KI++DQV DYA RK + E VERWL+P L YD
Sbjct: 1194 LYFAHPKSKYFAVAKINRDQVEDYAKRKEMSVEVVERWLAPNLSYD 1239
>gi|37681144|ref|NP_935753.1| cobalamin-dependent methionine synthase
[Vibrio vulnificus YJ016]
gi|37199895|dbj|BAC95724.1| cobalamin-dependent methionine synthase
[Vibrio vulnificus YJ016]
Length = 1226
Score = 1269 bits (3284), Expect = 0.0
Identities = 654/1244 (52%), Positives = 866/1244 (69%), Gaps = 5/1244 (0%)
Frame = +1
Query: 10 SSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRP 189
S++ ++ K+RI++IDG MGTMIQ ++E+D+RGE D LKGNNDLL +T+P
Sbjct: 3 SNIRAQIEAQLKQRILLIDGGMGTMIQGYKLQEQDYRGERFADWHSDLKGNNDLLVLTQP 62
Query: 190 DIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAA 369
+I +IH YLEAGAD +ETNTF+ TTIA ADY E L EIN+ +A +AR A D+ A
Sbjct: 63 QLIKEIHHAYLEAGADILETNTFNATTIAMADYDMESLSEEINFAAAKLAREAADEWTAK 122
Query: 370 T-GRRRYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVE 546
+ RYV G +GPTNRT SISP V P +RNV+F ELV+AY + R+LI+GG D++L+E
Sbjct: 123 NPAKPRYVAGVLGPTNRTCSISPDVNDPGYRNVSFDELVEAYSESTRALIRGGSDLILIE 182
Query: 547 TVFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKP 726
T+FD+ NAKA FA+ ++FE+ G +PV +SGTI D SGRTLSGQT EAF S + +P
Sbjct: 183 TIFDTLNAKACAFAVESVFEELGFA-LPVMISGTITDASGRTLSGQTTEAFYNSLRHVRP 241
Query: 727 MAVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFAR 906
++ GLNCALG ++R +V+ +S+ S++F+ +PNAGLPNA G YD +PEEMA+ ++E+A+
Sbjct: 242 ISFGLNCALGPDELRPYVEELSRISETFVSTHPNAGLPNAFGEYDLSPEEMAEHVKEWAQ 301
Query: 907 DGLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVN 1086
G +N+IGGCCGTTP+HI M AV+G +PRV P+ P A + LSGLEP + +T FVN
Sbjct: 302 SGFLNLIGGCCGTTPEHIRHMAMAVEGESPRVLPEIPVACR--LSGLEPLTIAKDTLFVN 359
Query: 1087 IGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLR 1266
+GER NV GS RF LIK E YD A+DVAR QV++GAQI+D+NMD+G+LD M +FL
Sbjct: 360 VGERTNVTGSARFKRLIKEELYDEALDVAREQVENGAQIIDINMDEGMLDAEACMVRFLN 419
Query: 1267 LISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGA 1446
L +SEP+++K+P+ +DSS ++VI AGL+ QGK +VNSISLKEG+EKF E+A++I+RYGA
Sbjct: 420 LCASEPEISKVPIMVDSSKWEVIEAGLKCIQGKGIVNSISLKEGKEKFVEQAKLIRRYGA 479
Query: 1447 AVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNY 1626
AV+VMAFDE GQA + K EIC ++YRIL +EVGF P D+IFD NI +ATG++EH+NY
Sbjct: 480 AVIVMAFDEVGQADTRERKLEICTKAYRILVDEVGFPPEDVIFDPNIFAVATGIDEHNNY 539
Query: 1627 GMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVN 1806
+ FIEA I+ +LP A +SGGVSN+SFSFRG +REA+H+VFL++ K GMDMGIVN
Sbjct: 540 AVDFIEAVADIKRDLPHAMISGGVSNVSFSFRGNNYVREAIHAVFLYHCFKNGMDMGIVN 599
Query: 1807 AGALPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEM--XXXXXXXXXXXXEWRSLT 1980
AG L +Y+++ + NR +ATE+LL A+E EWR+ +
Sbjct: 600 AGQLEIYDNVPEKLREAVEDVVLNRRDDATERLLEIAEEYRENAVGKQEDASALEWRTWS 659
Query: 1981 VEERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFL 2160
VE+RL+ ALVKG+ +F+V DTEEAR N +K PL VIE PLMDGM VVG+LFG GKMFL
Sbjct: 660 VEKRLEHALVKGITEFIVEDTEEARLNASK---PLEVIEGPLMDGMNVVGDLFGEGKMFL 716
Query: 2161 PQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKN 2340
PQV+KSARVMK+AVAHL PF+ +Q G +++ATVKGDVHDIGKN
Sbjct: 717 PQVVKSARVMKQAVAHLEPFINASKQVGSS-----------NGKILLATVKGDVHDIGKN 765
Query: 2341 IVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRV 2520
IV VVL CNN++++DLGVM PCE I+K A E++ D IGLSGLITPSLDEMV+VAKEM R+
Sbjct: 766 IVGVVLQCNNYEIIDLGVMVPCEQILKVAKEQQVDIIGLSGLITPSLDEMVHVAKEMERL 825
Query: 2521 GLNIPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLN 2700
G ++PLLIGGATTSK HTAVKI Y HPVV+ +AS++V VC+SL +R AF++ L
Sbjct: 826 GFDLPLLIGGATTSKAHTAVKIEQNYSHPVVYVNNASRAVGVCTSLLSDELRPAFVERLQ 885
Query: 2701 EDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIP 2880
DYE VR +H + L R K IDW +T PS G + +FD+ L
Sbjct: 886 ADYELVRDQHNRKKPRTKPVTLEAARANKVAIDWQSYTPPAPSQPGVHVFDDFDVATLRQ 945
Query: 2881 YIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAV 3060
YIDW PFF W L GKYP IF+ +VG EAK++F+DA WL ++ E +L A +
Sbjct: 946 YIDWTPFFLTWSLVGKYPT-----IFEHEEVGEEAKRLFEDANEWLDRIEQEGLLKARGM 1000
Query: 3061 VSFLPAASEGDDMHVYDPETGNKL-DTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDD 3237
PAAS GDD+ VY E+ ++ + LRQQ+ + ++CLSD++ P ++G D
Sbjct: 1001 CGLFPAASVGDDIEVYTDESRTQVAKVLHNLRQQTEKPKG-ANYCLSDYVAPKESG-KKD 1058
Query: 3238 YLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYST 3417
++G FA T G+ E + DDY +IM++A+ADRLAEA+AEYLH+ VR +WGY+
Sbjct: 1059 WIGAFAVTGGVNERELADQFKAQGDDYNAIMIQAVADRLAEAFAEYLHERVRKEIWGYAA 1118
Query: 3418 NEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKN-GIGLTEHLAMLPAAS 3594
+E+L+ +L+ KYQGIRPA GYP+ P+HTEK LW+LL E+ G+ LT AM P AS
Sbjct: 1119 DENLSNEELIREKYQGIRPAPGYPACPEHTEKGPLWELLNVEETIGMSLTSSYAMWPGAS 1178
Query: 3595 VSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSP 3726
VSG YF++P S YFA+ +I QDQV YA RK E E+WL P
Sbjct: 1179 VSGWYFSHPDSRYFAIAQIQQDQVESYAKRKGWDLLEAEKWLGP 1222
>gi|17936039|ref|NP_532829.1| methionine synthase [Agrobacterium
tumefaciens str. C58]
gi|25285955|pir||AC2841 methionine synthase metH [imported] -
Agrobacterium tumefaciens (strain C58, Dupont)
gi|17740620|gb|AAL43145.1| methionine synthase [Agrobacterium
tumefaciens str. C58]
Length = 1257
Score = 1267 bits (3279), Expect = 0.0
Identities = 659/1247 (52%), Positives = 859/1247 (68%), Gaps = 4/1247 (0%)
Frame = +1
Query: 10 SSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRP 189
+ +F+ L + A ERI+I+DGAMGT IQ +E+ FRG+ KGNNDLL +T+P
Sbjct: 16 AEIFKALRDAASERILILDGAMGTQIQGLGFDEDHFRGDRFIGCACHQKGNNDLLILTQP 75
Query: 190 DIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAA 369
D I +IH Y AGAD +ETNTFS T IAQADY E+ V+++N + A + RRA
Sbjct: 76 DAIEEIHYRYAMAGADILETNTFSSTRIAQADYEMENAVYDLNREGAAIVRRAAQRAERE 135
Query: 370 TGRRRYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVET 549
GRRR+V GAIGPTNRT SISP V P +R V+F +L AYG+Q LI GG D++L+ET
Sbjct: 136 DGRRRFVAGAIGPTNRTASISPDVNNPGYRAVSFDDLRIAYGEQIDGLIDGGADIILIET 195
Query: 550 VFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKPM 729
+FD+ NAKAA+FA FE +G+ +PV +SGTI D+SGRTLSGQT AF S + P
Sbjct: 196 IFDTLNAKAAIFACEERFEAKGI-RLPVMISGTITDLSGRTLSGQTPSAFWNSVRHANPF 254
Query: 730 AVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFARD 909
+GLNCALGA MR + +S +D+F+ YPNAGLPN G YDETPE MA + F RD
Sbjct: 255 TIGLNCALGADAMRPHLQELSDVADTFVCAYPNAGLPNEFGQYDETPEMMARQVEGFVRD 314
Query: 910 GLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVNI 1089
GLVNI+GGCCG+TP+HI A+ +AV+ PR P+ H M LSGLEP ++ + FVN+
Sbjct: 315 GLVNIVGGCCGSTPEHIRAIAEAVKDYKPREIPE--HKPFMSLSGLEPFVLTKDIPFVNV 372
Query: 1090 GERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLRL 1269
GER NV GS RF LI +Y A+ VAR QV++GAQI+D+NMD+GL+D AM +FL L
Sbjct: 373 GERTNVTGSARFRKLITAGDYTAALAVARDQVENGAQIIDINMDEGLIDSEKAMVEFLNL 432
Query: 1270 ISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGAA 1449
I++EPD+A++PV IDSS F++I AGL+ QGK +VNSISLKEGEEKF ++AR++ YGAA
Sbjct: 433 IAAEPDIARVPVMIDSSKFEIIEAGLKCVQGKSIVNSISLKEGEEKFLQQARLVHNYGAA 492
Query: 1450 VVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNYG 1629
VVVMAFDE GQA K EIC R+Y++LTE+ G +P DIIFD N+ +ATG+EEH+NYG
Sbjct: 493 VVVMAFDEVGQADTYQRKVEICARAYKLLTEKAGLSPEDIIFDPNVFAVATGIEEHNNYG 552
Query: 1630 MYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVNA 1809
+ FIEA + IRE +P H+SGGVSN+SFSFRG E +REAMH+VFL++AI+ GMDMGIVNA
Sbjct: 553 VDFIEATKTIRETMPLTHISGGVSNLSFSFRGNEPVREAMHAVFLYHAIQVGMDMGIVNA 612
Query: 1810 GALPVYEDIDKPXXXXXXXXXFNRDPEATEKLL-VAAQEMXXXXXXXXXXXXEWRSLTVE 1986
G L VY++ID NR +ATE+LL VA + WR VE
Sbjct: 613 GQLAVYDNIDAELREACEDVVLNRRDDATERLLEVAERFRGTGEKQAKVQDLSWREYPVE 672
Query: 1987 ERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFLPQ 2166
+RL+ ALV G+ ++ ADTEEARQ A RPL+VIE PLM GM VVG+LFG+GKMFLPQ
Sbjct: 673 KRLEHALVNGITDYIEADTEEARQQAA---RPLHVIEGPLMAGMNVVGDLFGSGKMFLPQ 729
Query: 2167 VIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKNIV 2346
V+KSARVMK+AVA LLP+ME E++ N E G V++ATVKGDVHDIGKNIV
Sbjct: 730 VVKSARVMKQAVAVLLPYMEEEKRLN------GGSERSAAGKVLMATVKGDVHDIGKNIV 783
Query: 2347 SVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRVGL 2526
VVL CNN++++DLGVM P I++ AI EK D IGLSGLITPSLDEMV+VA EM R G
Sbjct: 784 GVVLACNNYEIIDLGVMVPTTKILETAIAEKVDVIGLSGLITPSLDEMVHVAAEMERQGF 843
Query: 2527 NIPLLIGGATTSKTHTAVKISPRYPH-PVVHCLDASKSVVVCSSLSDMSVRDAFLQDLNE 2703
+IPLLIGGATTS+ HTAVKI PRY ++ DAS++V V S+L + A++ +
Sbjct: 844 DIPLLIGGATTSRVHTAVKIHPRYEQGQAIYVTDASRAVGVVSALLSEEQKPAYIDGIRA 903
Query: 2704 DYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIPY 2883
+Y V + H + ++++ L++ RE KIDW ++ VKP F G + ++ +DL EL Y
Sbjct: 904 EYAKVAEAHARNEREKQRLPLSRARENAHKIDWSSYSVVKPQFFGTKVFETYDLEELSRY 963
Query: 2884 IDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAVV 3063
IDW PFF W+L+G+ +P I +D G A++++ DAQ L K+I+EK AV+
Sbjct: 964 IDWTPFFQTWELKGR-----FPAILEDEKQGEAARQLYADAQAMLAKIIEEKWFRPRAVI 1018
Query: 3064 SFLPAASEGDDMHVY-DPETGNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDDY 3240
F PA + GDD+ ++ D +L TF+ LRQQ + +P+ LSDF+ P+ +GV DY
Sbjct: 1019 GFWPANAVGDDIRLFTDEGRKEELATFFTLRQQLSKRDGRPNVALSDFVAPVDSGVA-DY 1077
Query: 3241 LGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYSTN 3420
+G F TAG+ + E+ +DDY+SI+VKALADR AEA+AE +H+ VR WGY+ +
Sbjct: 1078 VGGFVVTAGIEEVAIAERFERANDDYSSILVKALADRFAEAFAERMHERVRKEFWGYAPD 1137
Query: 3421 EDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEA-EKNGIGLTEHLAMLPAASV 3597
E L DL+ Y GIRPA GYP+QPDHTEK+TL+ LL+A G+ LTE AM P +SV
Sbjct: 1138 EALAGDDLIGEAYAGIRPAPGYPAQPDHTEKKTLFALLDATNAAGVELTESYAMWPGSSV 1197
Query: 3598 SGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGY 3738
SGLY +P+S YF V K+++DQV+DYA RK++P EVERWL P+L Y
Sbjct: 1198 SGLYIGHPESYYFGVAKVERDQVLDYARRKDMPVTEVERWLGPVLNY 1244
>gi|15889436|ref|NP_355117.1| AGR_C_3907p [Agrobacterium tumefaciens
str. C58]
gi|25285954|pir||E97618 methionine synthase (PA1843) [imported] -
Agrobacterium tumefaciens (strain C58, Cereon)
gi|15157296|gb|AAK87902.1| AGR_C_3907p [Agrobacterium tumefaciens
str. C58]
Length = 1259
Score = 1267 bits (3279), Expect = 0.0
Identities = 659/1247 (52%), Positives = 859/1247 (68%), Gaps = 4/1247 (0%)
Frame = +1
Query: 10 SSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRP 189
+ +F+ L + A ERI+I+DGAMGT IQ +E+ FRG+ KGNNDLL +T+P
Sbjct: 18 AEIFKALRDAASERILILDGAMGTQIQGLGFDEDHFRGDRFIGCACHQKGNNDLLILTQP 77
Query: 190 DIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAA 369
D I +IH Y AGAD +ETNTFS T IAQADY E+ V+++N + A + RRA
Sbjct: 78 DAIEEIHYRYAMAGADILETNTFSSTRIAQADYEMENAVYDLNREGAAIVRRAAQRAERE 137
Query: 370 TGRRRYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVET 549
GRRR+V GAIGPTNRT SISP V P +R V+F +L AYG+Q LI GG D++L+ET
Sbjct: 138 DGRRRFVAGAIGPTNRTASISPDVNNPGYRAVSFDDLRIAYGEQIDGLIDGGADIILIET 197
Query: 550 VFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKPM 729
+FD+ NAKAA+FA FE +G+ +PV +SGTI D+SGRTLSGQT AF S + P
Sbjct: 198 IFDTLNAKAAIFACEERFEAKGI-RLPVMISGTITDLSGRTLSGQTPSAFWNSVRHANPF 256
Query: 730 AVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFARD 909
+GLNCALGA MR + +S +D+F+ YPNAGLPN G YDETPE MA + F RD
Sbjct: 257 TIGLNCALGADAMRPHLQELSDVADTFVCAYPNAGLPNEFGQYDETPEMMARQVEGFVRD 316
Query: 910 GLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVNI 1089
GLVNI+GGCCG+TP+HI A+ +AV+ PR P+ H M LSGLEP ++ + FVN+
Sbjct: 317 GLVNIVGGCCGSTPEHIRAIAEAVKDYKPREIPE--HKPFMSLSGLEPFVLTKDIPFVNV 374
Query: 1090 GERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLRL 1269
GER NV GS RF LI +Y A+ VAR QV++GAQI+D+NMD+GL+D AM +FL L
Sbjct: 375 GERTNVTGSARFRKLITAGDYTAALAVARDQVENGAQIIDINMDEGLIDSEKAMVEFLNL 434
Query: 1270 ISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGAA 1449
I++EPD+A++PV IDSS F++I AGL+ QGK +VNSISLKEGEEKF ++AR++ YGAA
Sbjct: 435 IAAEPDIARVPVMIDSSKFEIIEAGLKCVQGKSIVNSISLKEGEEKFLQQARLVHNYGAA 494
Query: 1450 VVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNYG 1629
VVVMAFDE GQA K EIC R+Y++LTE+ G +P DIIFD N+ +ATG+EEH+NYG
Sbjct: 495 VVVMAFDEVGQADTYQRKVEICARAYKLLTEKAGLSPEDIIFDPNVFAVATGIEEHNNYG 554
Query: 1630 MYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVNA 1809
+ FIEA + IRE +P H+SGGVSN+SFSFRG E +REAMH+VFL++AI+ GMDMGIVNA
Sbjct: 555 VDFIEATKTIRETMPLTHISGGVSNLSFSFRGNEPVREAMHAVFLYHAIQVGMDMGIVNA 614
Query: 1810 GALPVYEDIDKPXXXXXXXXXFNRDPEATEKLL-VAAQEMXXXXXXXXXXXXEWRSLTVE 1986
G L VY++ID NR +ATE+LL VA + WR VE
Sbjct: 615 GQLAVYDNIDAELREACEDVVLNRRDDATERLLEVAERFRGTGEKQAKVQDLSWREYPVE 674
Query: 1987 ERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFLPQ 2166
+RL+ ALV G+ ++ ADTEEARQ A RPL+VIE PLM GM VVG+LFG+GKMFLPQ
Sbjct: 675 KRLEHALVNGITDYIEADTEEARQQAA---RPLHVIEGPLMAGMNVVGDLFGSGKMFLPQ 731
Query: 2167 VIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKNIV 2346
V+KSARVMK+AVA LLP+ME E++ N E G V++ATVKGDVHDIGKNIV
Sbjct: 732 VVKSARVMKQAVAVLLPYMEEEKRLN------GGSERSAAGKVLMATVKGDVHDIGKNIV 785
Query: 2347 SVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRVGL 2526
VVL CNN++++DLGVM P I++ AI EK D IGLSGLITPSLDEMV+VA EM R G
Sbjct: 786 GVVLACNNYEIIDLGVMVPTTKILETAIAEKVDVIGLSGLITPSLDEMVHVAAEMERQGF 845
Query: 2527 NIPLLIGGATTSKTHTAVKISPRYPH-PVVHCLDASKSVVVCSSLSDMSVRDAFLQDLNE 2703
+IPLLIGGATTS+ HTAVKI PRY ++ DAS++V V S+L + A++ +
Sbjct: 846 DIPLLIGGATTSRVHTAVKIHPRYEQGQAIYVTDASRAVGVVSALLSEEQKPAYIDGIRA 905
Query: 2704 DYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIPY 2883
+Y V + H + ++++ L++ RE KIDW ++ VKP F G + ++ +DL EL Y
Sbjct: 906 EYAKVAEAHARNEREKQRLPLSRARENAHKIDWSSYSVVKPQFFGTKVFETYDLEELSRY 965
Query: 2884 IDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAVV 3063
IDW PFF W+L+G+ +P I +D G A++++ DAQ L K+I+EK AV+
Sbjct: 966 IDWTPFFQTWELKGR-----FPAILEDEKQGEAARQLYADAQAMLAKIIEEKWFRPRAVI 1020
Query: 3064 SFLPAASEGDDMHVY-DPETGNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDDY 3240
F PA + GDD+ ++ D +L TF+ LRQQ + +P+ LSDF+ P+ +GV DY
Sbjct: 1021 GFWPANAVGDDIRLFTDEGRKEELATFFTLRQQLSKRDGRPNVALSDFVAPVDSGVA-DY 1079
Query: 3241 LGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYSTN 3420
+G F TAG+ + E+ +DDY+SI+VKALADR AEA+AE +H+ VR WGY+ +
Sbjct: 1080 VGGFVVTAGIEEVAIAERFERANDDYSSILVKALADRFAEAFAERMHERVRKEFWGYAPD 1139
Query: 3421 EDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEA-EKNGIGLTEHLAMLPAASV 3597
E L DL+ Y GIRPA GYP+QPDHTEK+TL+ LL+A G+ LTE AM P +SV
Sbjct: 1140 EALAGDDLIGEAYAGIRPAPGYPAQPDHTEKKTLFALLDATNAAGVELTESYAMWPGSSV 1199
Query: 3598 SGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGY 3738
SGLY +P+S YF V K+++DQV+DYA RK++P EVERWL P+L Y
Sbjct: 1200 SGLYIGHPESYYFGVAKVERDQVLDYARRKDMPVTEVERWLGPVLNY 1246
>gi|41176427|gb|AAR99583.1| 5-methyltetrahydrofolate-homocysteine
methyltransferase 2 [Sinorhizobium fredii]
Length = 1256
Score = 1264 bits (3270), Expect = 0.0
Identities = 671/1247 (53%), Positives = 856/1247 (67%), Gaps = 4/1247 (0%)
Frame = +1
Query: 10 SSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRP 189
S +F L + RI+I+DGAMGT IQ+ + E+ FRG+ +GNNDLL++T+P
Sbjct: 18 SEIFRVLRQATAGRILIMDGAMGTEIQQLGLAEDHFRGDRFGGCSCHQQGNNDLLTLTQP 77
Query: 190 DIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAA 369
I IH Y AGAD +ETNTFS T IAQADY E +V+E+N A +ARRA A
Sbjct: 78 KAIEDIHYRYAIAGADILETNTFSSTRIAQADYGMEDMVYELNRDGARLARRAAKRAEAE 137
Query: 370 TGRRRYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVET 549
GRRR+V GA+GPTNRT SISP V P +R VTF +L AY +Q LI GG D++L+ET
Sbjct: 138 DGRRRFVAGALGPTNRTASISPDVNNPGYRAVTFDDLRLAYAEQVHGLIDGGADIILIET 197
Query: 550 VFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKPM 729
VFD+ NAKAA+FA + +F ++GV +P+ +SGTI D+SGRTLSGQT EAF S + +P
Sbjct: 198 VFDTLNAKAAIFATQEIFAEKGV-RLPIMISGTITDLSGRTLSGQTSEAFWYSVRHAEPF 256
Query: 730 AVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFARD 909
+GLNCALGA MR +D +S +D+ I YPNAGLPN G YDE+PE MA + FARD
Sbjct: 257 TIGLNCALGANAMRAHIDELSSVADTLICAYPNAGLPNEFGRYDESPEAMAAQIEGFARD 316
Query: 910 GLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVNI 1089
GLVNI+GGCCG+TPDHI A+ +AV+ PR PQ +M LSGLEP E FVN+
Sbjct: 317 GLVNIVGGCCGSTPDHIRAIAEAVEKYPPREIPQIER--RMRLSGLEPFTFTDEIPFVNV 374
Query: 1090 GERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLRL 1269
GER NV GS +F LI +Y A+DVAR QV +GAQI+DVNMD+GL+D M +FL L
Sbjct: 375 GERTNVTGSAKFRKLITAGDYAAALDVARDQVANGAQIIDVNMDEGLIDSKQVMVEFLNL 434
Query: 1270 ISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGAA 1449
++SEPD+A++PV IDSS ++VI AGL+ QGK +VNSISLKEGEE F + AR+++ YGAA
Sbjct: 435 VASEPDIARVPVMIDSSKWEVIEAGLQCVQGKALVNSISLKEGEEAFLDHARLVRAYGAA 494
Query: 1450 VVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNYG 1629
VVVMAFDE+GQA K EIC R+YR+LTE VGF P DIIFD NI +ATG+EEH+NYG
Sbjct: 495 VVVMAFDEKGQADTKARKVEICTRAYRLLTENVGFPPEDIIFDPNIFAVATGIEEHNNYG 554
Query: 1630 MYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVNA 1809
+ FIEAA I +LP HVSGGVSN+SFSFRG E +REAMH+VFL++AI+AGMDMGIVNA
Sbjct: 555 VDFIEAAHEIIASLPHVHVSGGVSNLSFSFRGNEPVREAMHAVFLYHAIQAGMDMGIVNA 614
Query: 1810 GALPVYEDIDKPXXXXXXXXXFNRDPEATEKLL-VAAQEMXXXXXXXXXXXXEWRSLTVE 1986
G L VY+ ID NR +ATE+LL VA WR +VE
Sbjct: 615 GQLAVYDAIDPDLREACEDVVLNRRADATERLLEVAKGYRGQGGAQGREKDLAWRQWSVE 674
Query: 1987 ERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFLPQ 2166
+RL+ ALV G+ +F+ ADTEEAR+ RPL+VIE PLM GM VVG+LFGAGKMFLPQ
Sbjct: 675 KRLEHALVNGITEFIEADTEEARRAA---ERPLHVIEGPLMAGMNVVGDLFGAGKMFLPQ 731
Query: 2167 VIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKNIV 2346
V+KSARVMK+AVA LLP+ME+E+ AN D G +++ATVKGDVHDIGKNIV
Sbjct: 732 VVKSARVMKQAVAVLLPYMEVEKAAN------GGDARESAGKILMATVKGDVHDIGKNIV 785
Query: 2347 SVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRVGL 2526
VVL CNN++++DLGVM P I++ A E+K D IGLSGLITPSLDEMV+VA E+ R G
Sbjct: 786 GVVLACNNYEIIDLGVMVPSARILEVAREQKVDAIGLSGLITPSLDEMVHVASELEREGF 845
Query: 2527 NIPLLIGGATTSKTHTAVKISPRYP-HPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLNE 2703
+IPLLIGGATTS+ HTAVKI+PRY V+ DAS++V V SSL R+A+ + +
Sbjct: 846 DIPLLIGGATTSRVHTAVKINPRYTLGQTVYVTDASRAVGVVSSLMSPEAREAYQETVRA 905
Query: 2704 DYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIPY 2883
+Y V + H + ++R L+K R ++DWD + PSF+G R ++++DL EL Y
Sbjct: 906 EYLKVAEAHARNEAEKRRLPLSKARANAHRLDWDAYRPKTPSFLGTRVFESWDLAELARY 965
Query: 2884 IDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAVV 3063
IDW PFF W+L+G YP+I D GA A+++FDDAQ + K++ EK AVV
Sbjct: 966 IDWTPFFQAWELKG-----VYPRILADEKQGAAARQLFDDAQAMVAKIVAEKWFAPKAVV 1020
Query: 3064 SFLPAASEGDDMHVY-DPETGNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDDY 3240
F PA S GDD+ ++ D ++L T + LRQQ + +P+ LSDF+ P ++G DY
Sbjct: 1021 GFWPAGSIGDDIRLFTDENRRSELATLFTLRQQLAKRDGRPNVALSDFVAPAESG-RGDY 1079
Query: 3241 LGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYSTN 3420
+G F TAG+ + E+ +DDY+SIMVKALADR AEA+AE +H+ VR LW Y+
Sbjct: 1080 VGGFVVTAGIEEVALAERFERANDDYSSIMVKALADRFAEAFAERMHEYVRKELWAYAPE 1139
Query: 3421 EDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKN-GIGLTEHLAMLPAASV 3597
E T +L++ Y+GIRPA GYP+QPDHTEK TL++LL+AE G+ LTE AM P +SV
Sbjct: 1140 EAFTPEELIAEPYRGIRPAPGYPAQPDHTEKETLFRLLDAEAAIGVKLTESFAMWPGSSV 1199
Query: 3598 SGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGY 3738
SGLY +P + YF V KI++DQV DYA RK + E ERWLSPIL Y
Sbjct: 1200 SGLYIGHPDAYYFGVAKIERDQVEDYAQRKRMGVHEAERWLSPILNY 1246
>gi|28899491|ref|NP_799096.1| cobalamin-dependent methionine synthase
[Vibrio parahaemolyticus RIMD 2210633]
gi|28807727|dbj|BAC60980.1| cobalamin-dependent methionine synthase
[Vibrio parahaemolyticus]
Length = 1226
Score = 1262 bits (3266), Expect = 0.0
Identities = 655/1244 (52%), Positives = 862/1244 (68%), Gaps = 5/1244 (0%)
Frame = +1
Query: 10 SSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRP 189
S + +++ K+RI++IDG MGTMIQ +EE+D+RGE + LKGNNDLL +++P
Sbjct: 3 SKVRQQIEAQLKQRILLIDGGMGTMIQGYKLEEQDYRGERFANWHCDLKGNNDLLVLSQP 62
Query: 190 DIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAA 369
+I +IH YLEAGAD +ETNTF+ TTIA ADY E L EIN+ +A +AR D+ A
Sbjct: 63 QLIKEIHSAYLEAGADILETNTFNATTIAMADYEMESLSEEINFAAAKLAREVADEWTAK 122
Query: 370 T-GRRRYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVE 546
T + RYV G +GPTNRT SISP V P +RNV+F ELV+AY + R+LI+GG D++L+E
Sbjct: 123 TPDKPRYVAGVLGPTNRTCSISPDVNDPGYRNVSFDELVEAYSESTRALIRGGADLILIE 182
Query: 547 TVFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKP 726
T+FD+ NAKA FA+ ++FE+ GV +PV +SGTI D SGRTLSGQT EAF S + +P
Sbjct: 183 TIFDTLNAKACAFAVDSVFEELGVA-LPVMISGTITDASGRTLSGQTTEAFYNSLRHVRP 241
Query: 727 MAVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFAR 906
++ GLNCALG ++R +V+ +S+ S+SF+ +PNAGLPNA G YD +PE+MA+ ++E+A
Sbjct: 242 LSFGLNCALGPDELRPYVEELSRISESFVSAHPNAGLPNAFGEYDLSPEDMAEHVKEWAS 301
Query: 907 DGLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVN 1086
G +N+IGGCCGTTP+HI M +AV+G+TPR P P A + LSGLEP + ET F+N
Sbjct: 302 SGFLNLIGGCCGTTPEHIRQMAQAVEGVTPRALPDLPVACR--LSGLEPLTIEKETLFIN 359
Query: 1087 IGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLR 1266
+GER NV GS RF LIK E YD A++VAR QV++GAQI+D+NMD+G+LD M +FL
Sbjct: 360 VGERTNVTGSARFKRLIKEEQYDEALEVARQQVENGAQIIDINMDEGMLDAQACMVRFLN 419
Query: 1267 LISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGA 1446
L +SEP+++K+P+ +DSS ++VI AGL+ QGK +VNSISLKEG+EKF E+A++I+RYGA
Sbjct: 420 LCASEPEISKVPIMVDSSKWEVIEAGLKCIQGKGIVNSISLKEGKEKFVEQAKLIRRYGA 479
Query: 1447 AVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNY 1626
AV+VMAFDE GQA K EIC +YRIL +EVGF P DIIFD NI +ATG++EH+NY
Sbjct: 480 AVIVMAFDEVGQAETRTRKLEICTNAYRILVDEVGFPPEDIIFDPNIFAVATGIDEHNNY 539
Query: 1627 GMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVN 1806
+ FIEA I+ +LP A +SGGVSN+SFSFRG +REA+H+VFL++ K GMDMGIVN
Sbjct: 540 AVDFIEAVADIKRDLPHAMISGGVSNVSFSFRGNNYVREAIHAVFLYHCFKNGMDMGIVN 599
Query: 1807 AGALPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEMX--XXXXXXXXXXXEWRSLT 1980
AG L +Y+++ + NR +ATE+LL A E EWR+
Sbjct: 600 AGQLEIYDNVPEKLREAVEDVVLNRRDDATERLLDIAAEYADKGVGKEEDASALEWRTWP 659
Query: 1981 VEERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFL 2160
V +RL+ ALVKG+ +F+VADTEEAR N K PL VIE PLMDGM VVG+LFG GKMFL
Sbjct: 660 VAKRLEHALVKGITEFIVADTEEARVNAVK---PLEVIEGPLMDGMNVVGDLFGEGKMFL 716
Query: 2161 PQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKN 2340
PQV+KSARVMK+AVAHL PF+ E+Q+ G +++ATVKGDVHDIGKN
Sbjct: 717 PQVVKSARVMKQAVAHLEPFINAEKQSGSS-----------NGKILLATVKGDVHDIGKN 765
Query: 2341 IVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRV 2520
IV VVL CNN++++DLGVM PCE I+K AIEE D IGLSGLITPSLDEMV+VAKEM R+
Sbjct: 766 IVGVVLQCNNYEIIDLGVMVPCEKILKVAIEENVDIIGLSGLITPSLDEMVHVAKEMERL 825
Query: 2521 GLNIPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLN 2700
++PLLIGGATTSK HTAVKI Y +PVV+ +AS++V VCSSL R AF++ L+
Sbjct: 826 NFDLPLLIGGATTSKAHTAVKIEQNYKNPVVYVNNASRAVGVCSSLLSDERRPAFIEKLD 885
Query: 2701 EDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIP 2880
DYE VR +H + L + R K IDWD +T P+ G + +FD+ L
Sbjct: 886 ADYERVRDQHNRKKPRTKPVTLEQARANKVAIDWDAYTPPVPAKPGLHIFDDFDVATLRK 945
Query: 2881 YIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAV 3060
YIDW PFF W L GKYP IF +VG EA+++F DA L ++ E +L A +
Sbjct: 946 YIDWTPFFMTWSLVGKYPT-----IFKHEEVGEEAQRLFHDANELLDRVEREGLLKARGI 1000
Query: 3061 VSFLPAASEGDDMHVYDPETGNKL-DTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDD 3237
PAAS GDD+ VY E+ ++ LRQQ+ + ++CLSD+I P ++G D
Sbjct: 1001 CGLFPAASVGDDIEVYTDESRTEVAKVLRNLRQQTEKPKGF-NYCLSDYIAPKESG-KQD 1058
Query: 3238 YLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYST 3417
++G FA T G+G E + DDY +IM++A+ADRLAEA+AEYLH+ VR +WGY+
Sbjct: 1059 WVGAFAVTGGIGERELADEYKAQGDDYNAIMIQAVADRLAEAFAEYLHERVRKEIWGYAA 1118
Query: 3418 NEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKN-GIGLTEHLAMLPAAS 3594
+E+L+ +L+ KYQGIRPA GYP+ P+HTEK LW+LL E+N G+ LT AM P AS
Sbjct: 1119 DENLSNDELIREKYQGIRPAPGYPACPEHTEKGPLWELLNVEENIGMSLTTSYAMYPGAS 1178
Query: 3595 VSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSP 3726
VSG YF++P S YFA+ +I DQ+ YA RK + E E+WL P
Sbjct: 1179 VSGWYFSHPDSRYFAIAQIQDDQLESYADRKGWDRIEAEKWLGP 1222
>gi|45914288|ref|ZP_00192660.2| COG1410: Methionine synthase I,
cobalamin-binding domain [Mesorhizobium sp. BNC1]
Length = 1264
Score = 1257 bits (3252), Expect = 0.0
Identities = 672/1251 (53%), Positives = 857/1251 (67%), Gaps = 8/1251 (0%)
Frame = +1
Query: 10 SSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRP 189
S + L A+ERI+++DGAMGT IQ +E FRG+ +GNNDLL +T+P
Sbjct: 22 SEISAALKAAARERILVLDGAMGTQIQGLGFDESHFRGDRFGGCACHQQGNNDLLILTQP 81
Query: 190 DIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAA 369
I +IH Y AGAD +ETNTFS T IAQADY E +V+E+N A +ARRA
Sbjct: 82 KAIEEIHYQYAIAGADIIETNTFSSTRIAQADYGMEEMVYELNRDGARLARRAVKRAEQE 141
Query: 370 TGRRRYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVET 549
G+RR+V GA+GPTNRT SISP V P +R +TF +L A G+Q R LI GGVD++L+ET
Sbjct: 142 DGKRRFVAGALGPTNRTASISPDVNNPGYRAITFDDLRIANGEQIRGLIDGGVDIILIET 201
Query: 550 VFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKPM 729
+FD+ NAKAA+FA +F ++GV +PV +SGTI D+SGRTLSGQT AF S + P
Sbjct: 202 IFDTLNAKAAVFAAEEVFIEKGV-RLPVMISGTITDLSGRTLSGQTPTAFWHSVRHANPF 260
Query: 730 AVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFARD 909
+GLNCALGA MR + +S +D+F YPNAGLPN G YDE+PE MA + EFAR+
Sbjct: 261 TIGLNCALGAAAMRPHLAELSSAADTFTCAYPNAGLPNEFGQYDESPEAMAAQIEEFARE 320
Query: 910 GLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVNI 1089
GLVNI+GGCCG+TP+HI A+ +A PR P+ P M LSGLEP + + FVNI
Sbjct: 321 GLVNIVGGCCGSTPEHIRAIAEAAAKHKPRELPKPPRL--MRLSGLEPFTLSKDIPFVNI 378
Query: 1090 GERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLRL 1269
GER NV GS RF LI ++ A+DVAR QV +GAQ++DVNMD+GL+D AM ++L L
Sbjct: 379 GERTNVTGSARFRKLITAGDFAAALDVARDQVANGAQVIDVNMDEGLIDSKKAMVEYLNL 438
Query: 1270 ISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGAA 1449
I++EPD+A++PV IDSS ++VI AGL+ QGK +VNSIS+KEGEE F +AR+ + YGAA
Sbjct: 439 IAAEPDIARVPVMIDSSKWEVIEAGLKCVQGKPIVNSISMKEGEEAFLHQARLCRAYGAA 498
Query: 1450 VVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNYG 1629
VVVMAFDE GQA K EIC R+Y+ILTE+VGF P DIIFD NI +ATG+EEH NYG
Sbjct: 499 VVVMAFDETGQADTKARKVEICTRAYKILTEKVGFPPEDIIFDPNIFAVATGIEEHDNYG 558
Query: 1630 MYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVNA 1809
+ FIEAAR I + LP HVSGGVSN+SFSFRG E +REAMH+VFL++AI AGMDMGIVNA
Sbjct: 559 VDFIEAAREITKTLPHVHVSGGVSNLSFSFRGNEPVREAMHAVFLYHAIHAGMDMGIVNA 618
Query: 1810 GALPVYEDIDKPXXXXXXXXXFNRDPE----ATEKLL-VAAQEMXXXXXXXXXXXXEWRS 1974
G L VY+ ID NR PE ATE+LL +A + WR
Sbjct: 619 GQLAVYDTIDPELREACEDVVLNRKPEAGGTATERLLELAERYKGTGGKEAKERDLAWRE 678
Query: 1975 LTVEERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKM 2154
VE+RL+ ALV G+ +F+ DTEEARQ K RPL+VIE PLM GM VVG+LFGAGKM
Sbjct: 679 WPVEKRLEHALVNGITEFIEEDTEEARQ---KAERPLHVIEGPLMAGMNVVGDLFGAGKM 735
Query: 2155 FLPQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIG 2334
FLPQV+KSARVMK+AVA LLP+ME E+ AN G ES G +++ATVKGDVHDIG
Sbjct: 736 FLPQVVKSARVMKQAVAVLLPYMEAEKLAN----GGGGRES--AGKILMATVKGDVHDIG 789
Query: 2335 KNIVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMN 2514
KNIV VVL CNN++++DLGVM P I++ A +EK D IGLSGLITPSLDEMV+VA EM
Sbjct: 790 KNIVGVVLACNNYEIIDLGVMVPATKILQTARDEKVDIIGLSGLITPSLDEMVHVASEME 849
Query: 2515 RVGLNIPLLIGGATTSKTHTAVKISPRYPH-PVVHCLDASKSVVVCSSLSDMSVRDAFLQ 2691
R G +IPLLIGGATTS+ HTAVKI PRY ++ DAS++V S+L + +++
Sbjct: 850 REGFDIPLLIGGATTSRVHTAVKIHPRYSQGQAIYVTDASRAVGTVSNLLSPETKAEYVE 909
Query: 2692 DLNEDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNE 2871
L +Y+ V + H S +++ L K R+ ++IDW + KP+F+G + ++ +DL E
Sbjct: 910 TLRAEYKKVAEAHARSEAEKQRLPLAKARQNAYRIDWSNYQPPKPTFLGTKVFETWDLAE 969
Query: 2872 LIPYIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVA 3051
L YIDW PFF W+L+G+ YPKI +D GA A+++FDDAQ LKK+IDEK
Sbjct: 970 LSRYIDWTPFFQTWELKGR-----YPKILEDEKQGAAARQLFDDAQEMLKKIIDEKWFAP 1024
Query: 3052 NAVVSFLPAASEGDDMHVYDPETGN-KLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGV 3228
A + F PA S GDD+ +Y E+ N +L T + LRQQ + + + L+DFI P G
Sbjct: 1025 RAAIGFWPANSVGDDIRLYTDESRNEELATLFTLRQQLTKRDGKANLALADFIAPEGIGK 1084
Query: 3229 PDDYLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWG 3408
P DYLG F TAG+ + E+ +DDY+SI+VKALADR AEA+AE +H+ VR WG
Sbjct: 1085 P-DYLGGFVVTAGIEEVAIAERFERANDDYSSILVKALADRFAEAFAERMHERVRKEFWG 1143
Query: 3409 YSTNEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKN-GIGLTEHLAMLP 3585
Y+++E T +L+ Y+GIRPA GYP+QPDHTEK TL+ LL+AEKN G+ LTE AM P
Sbjct: 1144 YASDEAFTPEELIGEPYKGIRPAPGYPAQPDHTEKTTLFALLDAEKNTGVTLTESYAMWP 1203
Query: 3586 AASVSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGY 3738
+SVSGLY A+P+S YF V K+++DQV DYA RK + EVERWL P+L Y
Sbjct: 1204 GSSVSGLYLAHPESYYFGVAKVERDQVEDYARRKGMETAEVERWLGPVLNY 1254
>gi|28869919|ref|NP_792538.1| 5-methyltetrahydrofolate--homocysteine
methyltransferase [Pseudomonas syringae pv. tomato str.
DC3000]
gi|28853164|gb|AAO56233.1| 5-methyltetrahydrofolate--homocysteine
methyltransferase [Pseudomonas syringae pv. tomato str.
DC3000]
Length = 1239
Score = 1256 bits (3251), Expect = 0.0
Identities = 658/1258 (52%), Positives = 855/1258 (67%), Gaps = 13/1258 (1%)
Frame = +1
Query: 7 RSSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITR 186
RS+ + K+RI+I+DG MGTMIQ +EEED+RG+ D +KGNNDLL +TR
Sbjct: 4 RSARHQAFITALKQRILILDGGMGTMIQSYRLEEEDYRGKRFADWPSDVKGNNDLLILTR 63
Query: 187 PDIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGA 366
PD+I I K YL+AGAD +ETNTF+ T ++QADY E +V+E+N + A +AR+ D
Sbjct: 64 PDVIGAIEKAYLDAGADILETNTFNATQVSQADYGMESIVYELNVEGARLARKVADAKTL 123
Query: 367 AT-GRRRYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLV 543
T + R+V G +GPT+RT S+SP V P +RNVTF ELV+ Y + + LI+GG D++L+
Sbjct: 124 ETPDKPRFVAGVLGPTSRTCSLSPDVNNPGYRNVTFDELVENYTEATKGLIEGGADLILI 183
Query: 544 ETVFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGK 723
ET+FD+ NAKAA+FA++ +FE+ G E+P+ +SGTI D SGRTLSGQT EAF S K
Sbjct: 184 ETIFDTLNAKAAIFAVQGVFEELGF-ELPIMISGTITDASGRTLSGQTTEAFWNSISHAK 242
Query: 724 PMAVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFA 903
P++VGLNCALGA ++R ++ ++ +++ + +PNAGLPNA G YDE P + A ++ EFA
Sbjct: 243 PVSVGLNCALGASELRPYLQELANKANTHVSAHPNAGLPNAFGEYDELPSQTAKIIEEFA 302
Query: 904 RDGLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFV 1083
+ G +NI+GGCCGTTP+HI A+ +AV G PR P P A + LSGLEP + ++ FV
Sbjct: 303 QSGFLNIVGGCCGTTPEHIKAIAEAVSGYAPREIPDIPKACR--LSGLEPFTIDRQSLFV 360
Query: 1084 NIGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFL 1263
N+GER N+ GS RF LI+ +NY A++VA QV++GAQ++D+NMD+G+LD AM FL
Sbjct: 361 NVGERTNITGSARFARLIREDNYTEALEVALQQVEAGAQVIDINMDEGMLDSKKAMVTFL 420
Query: 1264 RLISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYG 1443
LI+ EPD++++P+ IDSS ++VI AGL+ QGK +VNSIS+KEG E+F AR+ KRYG
Sbjct: 421 NLIAGEPDISRVPIMIDSSKWEVIEAGLKCIQGKGIVNSISMKEGVEQFIHHARLCKRYG 480
Query: 1444 AAVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSN 1623
AAVVVMAFDEQGQA K EIC+RSY IL EVGF P DIIFD NI IATG+EEH+N
Sbjct: 481 AAVVVMAFDEQGQADTEARKKEICKRSYDILVNEVGFPPEDIIFDPNIFAIATGIEEHNN 540
Query: 1624 YGMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIV 1803
Y + FI A IR+ LP A SGGVSN+SFSFRG +REA+HSVFL +AI+ G+ MGIV
Sbjct: 541 YAVDFINACAYIRDELPHALTSGGVSNVSFSFRGNNPVREAIHSVFLLHAIRNGLSMGIV 600
Query: 1804 NAGALPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEMXXXXXXXXXXXXEWRSLTV 1983
NAG L +Y+ I NR+PE TE LL A + EWRS V
Sbjct: 601 NAGQLEIYDQIPAELRDCVEDVVLNRNPEGTEALLAIADKYKGDGSVKEAETEEWRSWPV 660
Query: 1984 EERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFLP 2163
+RL+ ALVKG+ +V DTEE+R + RP+ VIE PLM GM VVG+LFGAGKMFLP
Sbjct: 661 NQRLEHALVKGITTHIVQDTEESRLG---FTRPIEVIEGPLMSGMNVVGDLFGAGKMFLP 717
Query: 2164 QVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKNI 2343
QV+KSARVMK+AVAHL+PF+E+E+ D+ +G +++ATVKGDVHDIGKNI
Sbjct: 718 QVVKSARVMKQAVAHLIPFIELEK----------GDKPEAKGKILMATVKGDVHDIGKNI 767
Query: 2344 VSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRVG 2523
V VVLGCN + +VDLGVM P E I++ A +EK D IGLSGLITPSLDEMV+VA+EM R
Sbjct: 768 VGVVLGCNGYDIVDLGVMVPAEKILQVARDEKCDIIGLSGLITPSLDEMVHVAREMQRQD 827
Query: 2524 LNIPLLIGGATTSKTHTAVKISPRYPH-PVVHCLDASKSVVVCSSLSDMSVRDAFLQDLN 2700
++PL+IGGATTSK HTAVKI P+Y + V++ DAS++V V + L ++ AF++
Sbjct: 828 FHLPLMIGGATTSKAHTAVKIEPKYSNDAVIYVTDASRAVGVATQLLSKELKPAFIEKTR 887
Query: 2701 EDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIP 2880
+Y +VR+ A KK K DW+ +T KP+F G R Q+ DLN L
Sbjct: 888 LEYVEVRERTSARSARTERLSYGAAVAKKPKFDWESYTPAKPTFTGTRVLQDIDLNVLAD 947
Query: 2881 YIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAV 3060
YIDW PFF W L GK YP+I D VG A +F+DAQ L+KLIDEK++ A AV
Sbjct: 948 YIDWTPFFISWDLAGK-----YPRILTDEVVGEAATALFEDAQQMLRKLIDEKLISARAV 1002
Query: 3061 VSFLPAAS-EGDDMHVYDPETGNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDD 3237
F P DD+ VY E G L + LRQQ+ + +P+F L+DF+ P +G+ D
Sbjct: 1003 FGFWPTNQINDDDLEVYG-EDGKPLAKLHHLRQQTIKPDGKPNFSLADFVAPKDSGL-TD 1060
Query: 3238 YLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYST 3417
Y+G F TAG+GAEE K + N DDY SIMVKALADRLAEA AE+LH++VR WGY+
Sbjct: 1061 YIGGFITTAGIGAEEVAKAYQDNGDDYNSIMVKALADRLAEACAEWLHQQVRKDYWGYAK 1120
Query: 3418 NEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLE----------AEKNGIGLTE 3567
+E L L+ +Y GIRPA GYP+ PDHTEK TL+ LL+ K+G+ LTE
Sbjct: 1121 DEALDNEALIKEQYMGIRPAPGYPACPDHTEKGTLFALLDPLPEGTPEHTPGKSGVFLTE 1180
Query: 3568 HLAMLPAASVSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGYD 3741
H AM PAA+VSG YFA+PQ++YFAVGK+D+DQV Y ARK ERWL+P LGYD
Sbjct: 1181 HYAMFPAAAVSGWYFAHPQAQYFAVGKVDKDQVESYTARKGQDLSVTERWLAPNLGYD 1238
>gi|26989099|ref|NP_744524.1| 5-methyltetrahydrofolate--homocysteine
methyltransferase [Pseudomonas putida KT2440]
gi|24983930|gb|AAN67988.1| 5-methyltetrahydrofolate--homocysteine
methyltransferase [Pseudomonas putida KT2440]
Length = 1235
Score = 1255 bits (3248), Expect = 0.0
Identities = 663/1255 (52%), Positives = 859/1255 (67%), Gaps = 9/1255 (0%)
Frame = +1
Query: 7 RSSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITR 186
RS+ + L KERI+I+DG MGTMIQ +EE D+RG D +KGNNDLL ++R
Sbjct: 4 RSARLQALQNALKERILILDGGMGTMIQSYRLEEHDYRGTRFADWPSDVKGNNDLLLLSR 63
Query: 187 PDIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGA 366
PD+I I K YL+AGAD +ETNTF+ T I+QADY E LV+E+N + A +AR+ D
Sbjct: 64 PDVIAAIEKAYLDAGADILETNTFNATQISQADYGMESLVYELNVEGARIARQVADAKTL 123
Query: 367 AT-GRRRYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLV 543
T + R+V G +GPT+RT SISP V P FRNVTF ELV+ Y + R LI+GG D++L+
Sbjct: 124 ETPDKPRFVAGVLGPTSRTCSISPDVNDPGFRNVTFDELVENYIEATRGLIEGGADLILI 183
Query: 544 ETVFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGK 723
ET+FD+ NAKAA+FA++ +FED+ V E+P+ +SGTI D SGRTLSGQT EAF S + K
Sbjct: 184 ETIFDTLNAKAAIFAVQQVFEDDNV-ELPIMISGTITDASGRTLSGQTTEAFWNSVRHAK 242
Query: 724 PMAVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFA 903
P++VGLNCALGAKD+R +++ ++ +D+ + +PNAGLPNA G YDETP EMA V+ EFA
Sbjct: 243 PISVGLNCALGAKDLRPYLEELATKADTHVSAHPNAGLPNAFGEYDETPAEMAAVVEEFA 302
Query: 904 RDGLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFV 1083
G +NIIGGCCGTTP HI A+ +AV PR P+ A + LSGLEP + ++ FV
Sbjct: 303 ASGFLNIIGGCCGTTPGHIQAIAEAVAKYKPREIPEIAKACR--LSGLEPFTIDRQSLFV 360
Query: 1084 NIGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFL 1263
N+GER N+ GS +F LI+ ENY A++VA QV++GAQ++D+NMD+G+LD AM +FL
Sbjct: 361 NVGERTNITGSAKFARLIREENYTEALEVALQQVEAGAQVIDINMDEGMLDSQAAMVRFL 420
Query: 1264 RLISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYG 1443
LI+ EPD++++P+ IDSS ++VI AGL+ QGK +VNSIS+KEG E+FK AR+ KRYG
Sbjct: 421 NLIAGEPDISRVPIMIDSSKWEVIEAGLKCIQGKGIVNSISMKEGVEQFKHHARLCKRYG 480
Query: 1444 AAVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSN 1623
AAVVVMAFDE GQA K EIC+RSY IL EVGF P DIIFD NI +ATG+EEH+N
Sbjct: 481 AAVVVMAFDEVGQADTAARKKEICQRSYDILVNEVGFPPEDIIFDPNIFAVATGIEEHNN 540
Query: 1624 YGMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIV 1803
Y + FIEA IR++LP A SGGVSN+SFSFRG +REA+HSVFL++AI+ G+ MGIV
Sbjct: 541 YAVDFIEACAYIRDHLPHALSSGGVSNVSFSFRGNNPVREAIHSVFLYHAIQNGLTMGIV 600
Query: 1804 NAGALPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEMXXXXXXXXXXXXEWRSLTV 1983
NAG L +Y++I NR P T+ LL A + EWRSL V
Sbjct: 601 NAGQLEIYDEIPAQLREKVEDVVLNRTPHGTDALLAIADDYKGGGATKEVENEEWRSLPV 660
Query: 1984 EERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFLP 2163
E+RL+ ALVKG+ F+V DTE RQ A RP+ VIE PLM+GM VVG+LFGAGKMFLP
Sbjct: 661 EKRLEHALVKGITAFIVEDTEACRQQCA---RPIEVIEGPLMNGMNVVGDLFGAGKMFLP 717
Query: 2164 QVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKNI 2343
QV+KSARVMK+AVAHL+PF+E E+ D+ +G +++ATVKGDVHDIGKNI
Sbjct: 718 QVVKSARVMKQAVAHLIPFIEAEK----------GDKPEAKGKILMATVKGDVHDIGKNI 767
Query: 2344 VSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRVG 2523
V VVLGCN + +VDLGVM P E I++ A E+K D IGLSGLITPSLDEMV+VA+EM R G
Sbjct: 768 VGVVLGCNGYDIVDLGVMVPAEKILQTAREQKCDIIGLSGLITPSLDEMVHVAREMQRQG 827
Query: 2524 LNIPLLIGGATTSKTHTAVKISPRYPH-PVVHCLDASKSVVVCSSLSDMSVRDAFLQDLN 2700
+PL+IGGATTSK HTAVKI P+Y + V++ DAS++V V + L ++ F++
Sbjct: 828 FELPLMIGGATTSKAHTAVKIEPKYSNDAVIYVTDASRAVGVATQLLSKELKPGFVEKTR 887
Query: 2701 EDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIP 2880
+Y DVR+ + K + DW + PSF G + ++ DL L
Sbjct: 888 LEYVDVRERTANRSARTERLSYAQAIAAKPQYDWAGYQPTAPSFTGVKVLEDIDLRTLAE 947
Query: 2881 YIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAV 3060
YIDW PFF W L GK +P+I D VG A ++ DA+ L KLIDEK++ A AV
Sbjct: 948 YIDWTPFFISWDLAGK-----FPRILTDEVVGEAATALYKDAREMLDKLIDEKLISARAV 1002
Query: 3061 VSFLPAAS-EGDDMHVYDPETGNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDD 3237
F PA + DD+ VY E G L T + LRQQ+ + +P++ L+DF+ P +GV D
Sbjct: 1003 FGFWPANQVDDDDIEVYG-EDGQALATLHHLRQQTIKPDGKPNWSLADFVAPKDSGV-TD 1060
Query: 3238 YLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYST 3417
Y+G F TAG+GAEE K + DDY+SIMVKALADRLAEA AE+LH++VR WGY+
Sbjct: 1061 YVGGFITTAGIGAEEVAKAYQDKGDDYSSIMVKALADRLAEACAEWLHEQVRKEHWGYAR 1120
Query: 3418 NEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLL------EAEKNGIGLTEHLAM 3579
+E L L+ +Y GIRPA GYP+ PDHTEK TL++LL E +G+ LTEH AM
Sbjct: 1121 DEHLDNEALIKEQYSGIRPAPGYPACPDHTEKETLFRLLDGTAIGETGPSGVYLTEHFAM 1180
Query: 3580 LPAASVSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGYDT 3744
PAA+VSG YFA+PQ++YFAVGK+D+DQ+ Y+ARK ERWL+P LGYD+
Sbjct: 1181 FPAAAVSGWYFAHPQAKYFAVGKVDKDQIERYSARKGQDISVSERWLAPNLGYDS 1235
>gi|48863132|ref|ZP_00317026.1| COG1410: Methionine synthase I,
cobalamin-binding domain [Microbulbifer degradans 2-40]
Length = 1233
Score = 1254 bits (3246), Expect = 0.0
Identities = 658/1247 (52%), Positives = 860/1247 (68%), Gaps = 7/1247 (0%)
Frame = +1
Query: 22 EELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRPDIIY 201
+ L +ERI+I+DGAMGTMIQ ++E D+RGE +H + L GNNDLL++T+P I+
Sbjct: 10 DSLYAALEERILILDGAMGTMIQSYKLQEADYRGERFANHHQDLGGNNDLLALTQPVILR 69
Query: 202 KIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAATGRR 381
IH+ YL+AGAD +ETNTF+ T I+QADY + + +E+N +SA +AR D+V T +
Sbjct: 70 DIHRAYLDAGADILETNTFNSTQISQADYDTQEIAYELNKESAAIARAVADEVTLETPNK 129
Query: 382 -RYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVETVFD 558
R+V G +GPT+RT SISP V P RNVT+ ELV Y + LI+GG D++L+ET+FD
Sbjct: 130 PRFVAGVLGPTSRTCSISPDVNDPGARNVTYDELVTNYKEATLGLIEGGADIILIETIFD 189
Query: 559 SANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKPMAVG 738
+ NAKAA+FA++T+FED G E+P+ +SGTI D SGRTLSGQT EAF S KP+++G
Sbjct: 190 TLNAKAAVFAVKTVFEDIGY-ELPIMISGTITDASGRTLSGQTTEAFYNSLAHAKPLSIG 248
Query: 739 LNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFARDGLV 918
LNCALGA ++ +V +S+ S+ ++ +PNAGLPN G YD++ +EMADV+ +FA V
Sbjct: 249 LNCALGAAELEPYVRELSRVSNCYVSAHPNAGLPNEFGEYDQSAKEMADVVEKFAVKNYV 308
Query: 919 NIIGGCCGTTPDHINAMYKAVQGITPR-VPPQDPHAGKMLLSGLEPSIVGPETNFVNIGE 1095
NIIGGCCGTTP HI A+ + V R +P +P L+GLEP + ++ FVN+GE
Sbjct: 309 NIIGGCCGTTPQHIKAIAETVSKYPARKIPDIEPQCR---LAGLEPFNISKDSLFVNVGE 365
Query: 1096 RCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLRLIS 1275
RCN+ GS RF LI +Y TAI+VA QV GAQI+D+NMD+G+LD AM KFL L++
Sbjct: 366 RCNITGSARFKRLILEGDYTTAIEVALQQVTDGAQIIDINMDEGMLDAEAAMIKFLNLLA 425
Query: 1276 SEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGAAVV 1455
EPD+A++P+ +DSS +DVI+AGL+ QGK +VNSISLKEGE +F ERAR+ K YGAAV+
Sbjct: 426 GEPDIARVPIMVDSSKWDVIVAGLKCIQGKPIVNSISLKEGEAEFIERARLCKLYGAAVI 485
Query: 1456 VMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNYGMY 1635
VMAFDE GQA K EICERSY++LTE+ GF P DIIFD NI +ATG+EEH+NY +
Sbjct: 486 VMAFDEDGQADTAQRKIEICERSYKVLTEQAGFPPEDIIFDPNIFAVATGIEEHNNYAVD 545
Query: 1636 FIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVNAGA 1815
FIEA R IR+NLP A VSGGVSN+SFSFRG + +REA+HSVFL+YAI+AGM+MGIVNAG
Sbjct: 546 FIEATRWIRQNLPYAGVSGGVSNVSFSFRGNDPVREAIHSVFLYYAIQAGMNMGIVNAGQ 605
Query: 1816 LPVYEDIDKPXXXXXXXXXFNRDPEATEKLL-VAAQEMXXXXXXXXXXXXEWRSLTVEER 1992
L +Y+D+ K N++ TE LL +A Q WR L VE+R
Sbjct: 606 LAIYDDLPKELKDCVEDVILNKNDNGTEALLEIAEQYRGDGKAQASKEDLAWRELPVEKR 665
Query: 1993 LKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFLPQVI 2172
L+ +LVKG+ ++ ADTEEARQN +K P++VIE PLM GM VVG+LFG+GKMFLPQV+
Sbjct: 666 LEHSLVKGISAYIEADTEEARQNASK---PIDVIEGPLMAGMNVVGDLFGSGKMFLPQVV 722
Query: 2173 KSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKNIVSV 2352
KSARVMK++VA+L PF+E E+ + G +++ATVKGDVHDIGKNIV V
Sbjct: 723 KSARVMKQSVAYLQPFIEAEKTEGARS----------NGKILMATVKGDVHDIGKNIVGV 772
Query: 2353 VLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRVGLNI 2532
VL CNNF VVDLGVM PCE II AI E D IGLSGLITPSLDEMV VA+EM +N+
Sbjct: 773 VLQCNNFDVVDLGVMVPCEKIIDTAIAENCDMIGLSGLITPSLDEMVNVAREMQSRQVNL 832
Query: 2533 PLLIGGATTSKTHTAVKISPRYP-HPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLNEDY 2709
PLLIGGATTSK HTAVKI P++ + V+ DAS++V V S L + R F+ + E+Y
Sbjct: 833 PLLIGGATTSKAHTAVKIDPQFSLNQAVYVADASRAVGVASKLLSLDQRGPFIASIKEEY 892
Query: 2710 EDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIPYID 2889
E VR+ +++ KK ++DW+KFT P+F G + ++N+ L +L+ YID
Sbjct: 893 EAVRERRANRTSNKQLATYADAVNKKLQLDWNKFTPAVPAFTGTKVFENYPLEKLVEYID 952
Query: 2890 WKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAVVSF 3069
W PFF W L GK YPKIF D +G A ++F DAQ LKKLIDEK++ A+A + F
Sbjct: 953 WTPFFISWDLVGK-----YPKIFKDEVIGEAATQLFKDAQEILKKLIDEKLIQASATIGF 1007
Query: 3070 LPAASEG-DDMHVYDPETGNKLDTFYGLRQQSGRE-HDQPHFCLSDFIKPLKNGVPDDYL 3243
A + G DD++V D + G L + +RQQ + D L+DF+ P G+ +DY+
Sbjct: 1008 WRANTIGDDDINVMD-DNGKTLAELHHIRQQQIKNGADDVLMSLADFVAPQDTGL-NDYI 1065
Query: 3244 GLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYSTNE 3423
G F TAG G +E K E DDY +IMVKALADRLAEA+AE+LH+ VR WGY +E
Sbjct: 1066 GGFVVTAGHGVDELAKEYEAKGDDYNAIMVKALADRLAEAFAEHLHQRVRKEFWGYDQDE 1125
Query: 3424 DLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAE-KNGIGLTEHLAMLPAASVS 3600
+L DL+ KYQGIRPA GYP+ PDHTEKR L+ LL+AE G+ LTEH AM P A+VS
Sbjct: 1126 NLANEDLIREKYQGIRPAPGYPACPDHTEKRALFDLLDAEATTGVQLTEHYAMYPTAAVS 1185
Query: 3601 GLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGYD 3741
G YFA+P+++YF GKI +DQV A+RK + E+E+WL +L YD
Sbjct: 1186 GWYFAHPKAKYFNTGKIAKDQVESLASRKGLSTAEMEKWLQSVLDYD 1232
>gi|24372616|ref|NP_716658.1| 5-methyltetrahydrofolate--homocysteine
methyltransferase [Shewanella oneidensis MR-1]
gi|24346645|gb|AAN54103.1| 5-methyltetrahydrofolate--homocysteine
methyltransferase [Shewanella oneidensis MR-1]
Length = 1244
Score = 1251 bits (3238), Expect = 0.0
Identities = 652/1256 (51%), Positives = 861/1256 (67%), Gaps = 16/1256 (1%)
Frame = +1
Query: 28 LAEIAKE---RIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRPDII 198
LA+I + RI+I+DGAMGTMIQ +EE D+RGE KD +KGNNDLL +T+P II
Sbjct: 12 LADIRNQLSTRILILDGAMGTMIQGYKLEEADYRGERFKDWHTDVKGNNDLLVLTQPHII 71
Query: 199 YKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAATGR 378
+IH YL AGAD +ETNTF+ TTIA ADY + L EIN + A +AR ACD + ATG+
Sbjct: 72 KQIHTDYLLAGADIIETNTFNATTIAMADYDMQSLSAEINREGARLAREACDAIEQATGK 131
Query: 379 RRYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVETVFD 558
RYV G +GPTNRT SISP V P FRN+ F ELV AY + R+LI+GG D+++VET+FD
Sbjct: 132 PRYVAGVLGPTNRTCSISPDVNDPGFRNIHFDELVTAYCESTRALIEGGADIIMVETIFD 191
Query: 559 SANAKAALFAIRTLFED----EGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKP 726
+ NAKAALFAI T+F++ +PV +SGTI D SGRTL+GQT EAF S + KP
Sbjct: 192 TLNAKAALFAIETVFDELFGANSPARLPVMISGTITDASGRTLTGQTTEAFYNSLRHIKP 251
Query: 727 MAVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFAR 906
+++GLNCALG K++R +V+ +S+ ++ ++ +PNAGLPN GGYDETPE+MA V++E+AR
Sbjct: 252 LSIGLNCALGPKELRPYVEELSRIAECYVSAHPNAGLPNEFGGYDETPEDMAKVIQEWAR 311
Query: 907 DGLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVN 1086
+G++NIIGGCCG+TP+HI + +AV+ PRV P+ P A + L+GLEP + +T FVN
Sbjct: 312 EGMLNIIGGCCGSTPEHIKVIREAVEQFAPRVLPEIPVACR--LAGLEPLTIDAQTLFVN 369
Query: 1087 IGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLR 1266
+GER NV GS +F LIK ++ A+DVAR QV+SGAQI+D+NMD+G+LDG M KFL
Sbjct: 370 VGERTNVTGSAKFLKLIKEGKFEQALDVAREQVESGAQIIDINMDEGMLDGVEIMHKFLN 429
Query: 1267 LISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGA 1446
LI+SEPD++++P+ IDSS ++VI AGL+ QGK +VNSISLKEGEEKF E+A ++KRYGA
Sbjct: 430 LIASEPDISRVPIMIDSSKWEVIEAGLKCIQGKGIVNSISLKEGEEKFIEQATLVKRYGA 489
Query: 1447 AVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNY 1626
A ++MAFDEQGQA K EIC R+YR+L ++VGF P DIIFD NI IATG++EH NY
Sbjct: 490 AAIIMAFDEQGQADTKARKVEICTRAYRVLVDKVGFPPEDIIFDPNIFAIATGIDEHDNY 549
Query: 1627 GMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVN 1806
+ FI+A + I+ LP A +SGGVSN+SFSFRG +REA+H+VFL++AIK GMDMGIVN
Sbjct: 550 AVDFIDAIKEIKATLPHAMISGGVSNVSFSFRGNNPVREAIHAVFLYHAIKVGMDMGIVN 609
Query: 1807 AGALPVYEDIDKPXXXXXXXXXFN-----RDPEATEKLLVAAQEM-XXXXXXXXXXXXEW 1968
AG L +++DID N TE+LL A++ EW
Sbjct: 610 AGQLAIFDDIDPELKVRVENVVLNLPCPVEGSNNTEQLLEIAEKFRGDGSSSAKKEDLEW 669
Query: 1969 RSLTVEERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAG 2148
RS V +RL ALVKG+ +F+ DTE ARQ + RPL+VIE PLMDGM +VG+LFG+G
Sbjct: 670 RSWPVNQRLAHALVKGITEFIDEDTEAARQAAS---RPLDVIEGPLMDGMNIVGDLFGSG 726
Query: 2149 KMFLPQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHD 2328
KMFLPQV+KSARVMKKAVA+L PF+E E+ A G +++ TVK DVHD
Sbjct: 727 KMFLPQVVKSARVMKKAVAYLNPFIEKEKVA-----------GQSNGKILMVTVKSDVHD 775
Query: 2329 IGKNIVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKE 2508
IGKNIV VVL CN F+V DLGVM E I++A E D IG+SGLITPSLDEMV+ K
Sbjct: 776 IGKNIVGVVLACNGFEVFDLGVMVSVERILEAVKEHNIDIIGMSGLITPSLDEMVHNVKT 835
Query: 2509 MNRVGLNIPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFL 2688
+R GL IP +IGGAT SK HTAVKI+P YPH ++ DAS++V + S L + R A +
Sbjct: 836 FHREGLTIPAIIGGATCSKIHTAVKIAPHYPHGAIYIADASRAVPMVSKLVNNETRQATI 895
Query: 2689 QDLNEDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLN 2868
+ +Y+D+R + + K + L RE + + DW ++ KP+ +GR+ + ++ L
Sbjct: 896 DETYAEYDDMRTKRLSQAKRKEIVSLEAARENRCQHDWANYSPFKPNVLGRQVFDDYPLT 955
Query: 2869 ELIPYIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILV 3048
+L+ IDW PFF W+L G YP+I D VG EA+K+F D + LKK+I+EK L
Sbjct: 956 DLVDRIDWTPFFRAWELHG-----HYPEILSDKVVGVEAQKLFSDGKAMLKKIIEEKWLT 1010
Query: 3049 ANAVVSFLPAASEG-DDMHVYDPETGNKLD-TFYGLRQQSGREHDQPHFCLSDFIKPLKN 3222
A V+ PA + G DD+ +Y ET +++ T + LR Q R + +FCL+DF+ P +
Sbjct: 1011 AKGVIGLFPANTVGFDDIELYTDETRTEVELTTHHLRMQLERVGND-NFCLADFVAPKDS 1069
Query: 3223 GVPDDYLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTL 3402
GV DY+G FA TAG G +E+ E NHDDY +IM+K LADRLAEA+AE +H+ VR
Sbjct: 1070 GVA-DYMGGFAVTAGHGIDEHVARFEANHDDYNAIMLKCLADRLAEAFAERMHERVRKEF 1128
Query: 3403 WGYSTNEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEA-EKNGIGLTEHLAM 3579
WGY+ +E L L+ KY+GIRPA GYP+ PDHTEK LW+LL+ E + +TE AM
Sbjct: 1129 WGYAADEQLDNEALIREKYKGIRPAPGYPACPDHTEKGLLWELLKPNETIDLNITESYAM 1188
Query: 3580 LPAASVSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGYDTD 3747
P A+VSG YFA+P+S YF V I +DQV DYA RK + E E+WL+P+L YD +
Sbjct: 1189 FPTAAVSGWYFAHPKSRYFGVSNIGRDQVEDYAKRKGMTVAETEKWLAPVLDYDPE 1244
>gi|15966734|ref|NP_387087.1| PROBABLE
5-METHYLTETRAHYDROFOLATE--HOMOCYSTEINE METHYLTRANSFERASE
(METHIONINE SYNTHASE, VITAMIN-B12 DEPENDENT ISOZYME)
PROTEIN [Sinorhizobium meliloti 1021]
gi|15076006|emb|CAC47560.1| PROBABLE
5-METHYLTETRAHYDROFOLATE--HOMOCYSTEINE METHYLTRANSFERASE
(METHIONINE SYNTHASE, VITAMIN-B12 DEPENDENT ISOZYME)
PROTEIN [Sinorhizobium meliloti]
Length = 1257
Score = 1250 bits (3235), Expect = 0.0
Identities = 667/1247 (53%), Positives = 857/1247 (68%), Gaps = 4/1247 (0%)
Frame = +1
Query: 10 SSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRP 189
S +F +LA+ A ERI+I+DGAMGT IQ+ E+ FRGE +GNNDLL++T+P
Sbjct: 18 SEVFRQLAQAAAERILIMDGAMGTEIQQLGFVEDHFRGERFGGCACHQQGNNDLLTLTQP 77
Query: 190 DIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAA 369
I IH Y AGAD +ETNTFS T IAQADY E +V+++N A +ARRA A
Sbjct: 78 KAIEDIHYHYAIAGADILETNTFSSTRIAQADYGMEDMVYDLNRDGARLARRAAKRAEAE 137
Query: 370 TGRRRYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVET 549
GRRR+V GA+GPTNRT SISP V P +R V+F +L AY +Q R LI GG D++L+ET
Sbjct: 138 DGRRRFVAGALGPTNRTASISPDVNNPGYRAVSFDDLRLAYAEQVRGLIDGGADIILIET 197
Query: 550 VFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKPM 729
+FD+ NAKAA+FA + +F ++GV +PV +SGTI D+SGRTLSGQT AF S + P
Sbjct: 198 IFDTLNAKAAIFATQEVFAEKGV-RLPVMISGTITDLSGRTLSGQTPTAFWYSVRHADPF 256
Query: 730 AVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFARD 909
+GLNCALGA MR +D +S +D+ + YPNAGLPN G YDE+PE+MA + FARD
Sbjct: 257 TIGLNCALGANAMRAHIDELSAVADTLVCAYPNAGLPNEFGRYDESPEQMAAQVEGFARD 316
Query: 910 GLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVNI 1089
GLVNI+GGCCG+TP HI A+ +AV PR P+ +M LSGLEP + E FVN+
Sbjct: 317 GLVNIVGGCCGSTPAHIRAIAEAVAKYPPRRVPEIDR--RMRLSGLEPFTLTDEIPFVNV 374
Query: 1090 GERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLRL 1269
GER NV GS +F LI +Y A+DVAR QV +GAQI+DVNMD+GL+D M +FL L
Sbjct: 375 GERTNVTGSAKFRKLITAGDYAAALDVARDQVANGAQIIDVNMDEGLIDSKQVMVEFLNL 434
Query: 1270 ISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGAA 1449
++SEPD+A++PV IDSS ++VI AGL+ QGK +VNSISLKEGE F AR+++ YGAA
Sbjct: 435 VASEPDIARVPVMIDSSKWEVIEAGLKCVQGKALVNSISLKEGEAAFLHHARLVRAYGAA 494
Query: 1450 VVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNYG 1629
VVVMAFDE+GQA K EIC R+YR+LTEEVGF P DIIFD NI +ATG+EEH+NYG
Sbjct: 495 VVVMAFDEKGQADTKTRKVEICRRAYRLLTEEVGFPPEDIIFDPNIFAVATGIEEHNNYG 554
Query: 1630 MYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVNA 1809
+ FIEA I LP HVSGGVSN+SFSFRG E +REAMH++FL++AI+AGMDMGIVNA
Sbjct: 555 VDFIEATHEIIAALPHVHVSGGVSNLSFSFRGNEPVREAMHAIFLYHAIQAGMDMGIVNA 614
Query: 1810 GALPVYEDIDKPXXXXXXXXXFNRDPEATEKLL-VAAQEMXXXXXXXXXXXXEWRSLTVE 1986
G L VY+ ID NR ++TE+LL +A + WR VE
Sbjct: 615 GQLAVYDAIDPELRETCEDVVLNRRADSTERLLEIAERYRGKGGSQGKEKDLAWREWPVE 674
Query: 1987 ERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFLPQ 2166
+RL+ ALV G+ +F+ ADTEEAR RPL+VIE PLM GM VVG+LFG+GKMFLPQ
Sbjct: 675 KRLEHALVNGITEFIEADTEEAR---LAAERPLHVIEGPLMAGMNVVGDLFGSGKMFLPQ 731
Query: 2167 VIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKNIV 2346
V+KSARVMK+AVA LLP ME E++AN G A + + G +++ATVKGDVHDIGKNIV
Sbjct: 732 VVKSARVMKQAVAVLLPHMEEEKRAN--GGGEARESA---GKILMATVKGDVHDIGKNIV 786
Query: 2347 SVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRVGL 2526
VVL CNN++++DLGVM P I++ A E+K D +GLSGLITPSLDEM +VA E+ R G
Sbjct: 787 GVVLACNNYEIIDLGVMVPSAKILEVAREQKVDIVGLSGLITPSLDEMAHVASELEREGF 846
Query: 2527 NIPLLIGGATTSKTHTAVKISPRYP-HPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLNE 2703
++PLLIGGATTS+ HTAVKI+PRY V+ DAS++V V SSL VRD++ + +
Sbjct: 847 DVPLLIGGATTSRVHTAVKINPRYSLGQTVYVTDASRAVGVVSSLLSPEVRDSYKKTVRA 906
Query: 2704 DYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIPY 2883
+Y V H + ++R L++ R F+IDWD PSF+G R ++ +DL EL Y
Sbjct: 907 EYLKVADAHARNEAEKRRLPLSQARANAFRIDWDAHQPKVPSFLGTRVFEGWDLAELARY 966
Query: 2884 IDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAVV 3063
IDW PFF W+L+G +PKI DD GA A+++F+DAQ ++K++ E AV+
Sbjct: 967 IDWTPFFQTWELKG-----VFPKILDDERQGAAARQLFEDAQAMVEKIVAEAWFAPKAVI 1021
Query: 3064 SFLPAASEGDDMHVYDPETGN-KLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDDY 3240
F PAAS GDD+ ++ E +L TF+ LRQQ + +P+ L+DF+ P +G DY
Sbjct: 1022 GFWPAASMGDDVRLFADEVREAELATFFTLRQQMVKRDGRPNVALADFVAPAASG-KRDY 1080
Query: 3241 LGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYSTN 3420
+G F TAG+ + E+ +DDY+SIMVKALADR AEA+AE +H+ VR LWGY+ +
Sbjct: 1081 VGGFVVTAGIEEVAIAERFERANDDYSSIMVKALADRFAEAFAERMHEYVRKELWGYAPD 1140
Query: 3421 EDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKN-GIGLTEHLAMLPAASV 3597
E T +L++ Y GIRPA GYP+QPDHTEK TL++LL+AE G+ LTE AM P +SV
Sbjct: 1141 EAFTPQELIAEPYAGIRPAPGYPAQPDHTEKETLFRLLDAEAAIGVRLTESYAMWPGSSV 1200
Query: 3598 SGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGY 3738
SGLY +P S YF V KI++DQV DYA RK + EVERWLSPIL Y
Sbjct: 1201 SGLYVGHPDSYYFGVAKIERDQVEDYADRKRMSVREVERWLSPILNY 1247
>gi|17988042|ref|NP_540676.1| 5-METHYLTETRAHYDROFOLATE--HOMOCYSTEINE
METHYLTRANSFERASE [Brucella melitensis 16M]
gi|25285958|pir||AI3471 5-methyltetrahydrofolate-homocysteine
S-methyltransferase (EC 2.1.1.13) [imported] - Brucella
melitensis (strain 16M)
gi|17983789|gb|AAL52940.1| 5-METHYLTETRAHYDROFOLATE--HOMOCYSTEINE
METHYLTRANSFERASE [Brucella melitensis 16M]
Length = 1261
Score = 1250 bits (3234), Expect = 0.0
Identities = 657/1251 (52%), Positives = 858/1251 (68%), Gaps = 8/1251 (0%)
Frame = +1
Query: 10 SSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRP 189
S + L + A+ERI+I+DGAMGT IQ EE FRG+ D L+GNNDLL++T+P
Sbjct: 19 SEVLAALTQAARERILILDGAMGTQIQGLGFHEEHFRGDRFATCDCQLQGNNDLLTLTQP 78
Query: 190 DIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAA 369
I +IH Y AGAD +ETNTFS T+IAQADY E +V+++N A +ARRA
Sbjct: 79 KAIEEIHYAYAMAGADILETNTFSSTSIAQADYGMEAMVYDLNRDGARLARRAALRAEQK 138
Query: 370 TGRRRYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVET 549
GRRR+V GA+GPTNRT S+SP V P FR VTF ++ AY +Q R LI GG D++L+ET
Sbjct: 139 DGRRRFVAGALGPTNRTASLSPDVNNPGFRAVTFDDVRIAYSEQIRGLIDGGSDIILIET 198
Query: 550 VFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKPM 729
+FD+ NAKAA+FA +F ++GV +PV +SGTI D+SGRTLSGQT AF S + +P
Sbjct: 199 IFDTLNAKAAVFATEEVFAEKGV-RLPVMISGTITDLSGRTLSGQTPTAFWYSLRHARPF 257
Query: 730 AVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFARD 909
+GLNCALGA MR +D +S +D+FI YPNAGLPN G YDETPE MA + FARD
Sbjct: 258 TIGLNCALGANAMRAHLDELSGIADTFICAYPNAGLPNEFGQYDETPEAMAAQIEGFARD 317
Query: 910 GLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVNI 1089
GLVN++GGCCG+TPDHI A+ +AV PR P + P M LSGLEP + + FVNI
Sbjct: 318 GLVNVVGGCCGSTPDHIRAIAQAVAKYEPRKPAKVPPL--MRLSGLEPFTLTKDIPFVNI 375
Query: 1090 GERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLRL 1269
GER NV GS RF L+K ++ A+DVAR QV +GAQI+D+NMD+GL+D AM +FL L
Sbjct: 376 GERTNVTGSARFRKLVKAGDFAAALDVARDQVANGAQIIDINMDEGLIDSEKAMVEFLNL 435
Query: 1270 ISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGAA 1449
I++EPD+A++P+ +DSS ++VI AGL+ QGK VVNSISLKEGEE F AR+++ YGAA
Sbjct: 436 IAAEPDIARVPIMLDSSKWEVIEAGLKCVQGKAVVNSISLKEGEEAFLHHARLVRAYGAA 495
Query: 1450 VVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNYG 1629
VV+MAFDE GQA K EIC R+Y+ILTE+VGF P DIIFD NI +ATG+EEH+NYG
Sbjct: 496 VVIMAFDETGQADTQARKIEICTRAYKILTEQVGFPPEDIIFDPNIFAVATGIEEHNNYG 555
Query: 1630 MYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVNA 1809
+ FIEA R I LP H+SGGVSN+SFSFRG E +REAMH+VFL++AI+AGMDMGIVNA
Sbjct: 556 VDFIEATREIVRTLPHVHISGGVSNLSFSFRGNEPVREAMHAVFLYHAIQAGMDMGIVNA 615
Query: 1810 GALPVYEDIDKPXXXXXXXXXFNRDPE----ATEKLL-VAAQEMXXXXXXXXXXXXEWRS 1974
G L VY+ ID NR + ATE+LL +A + WR
Sbjct: 616 GQLAVYDTIDAELREACEDVVLNRPTKTGESATERLLEIAERFRDSGSREARTQDLSWRE 675
Query: 1975 LTVEERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKM 2154
VE+RL+ ALV G+ +++ ADTEEAR RPL+VIE PLM GM VVG+LFG+GKM
Sbjct: 676 WPVEKRLEHALVNGITEYIEADTEEAR---LAAERPLHVIEGPLMAGMNVVGDLFGSGKM 732
Query: 2155 FLPQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIG 2334
FLPQV+KSARVMK+AVA LLPFME E++ N + G V++ATVKGDVHDIG
Sbjct: 733 FLPQVVKSARVMKQAVAVLLPFMEEEKRLN------GGEGRQSAGKVLMATVKGDVHDIG 786
Query: 2335 KNIVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMN 2514
KNIV VVL CNN++++DLGVM P + I++ A +EK D IGLSGLITPSLDEM +VA EM
Sbjct: 787 KNIVGVVLACNNYEIIDLGVMVPSQKILQVARDEKVDIIGLSGLITPSLDEMAHVAAEME 846
Query: 2515 RVGLNIPLLIGGATTSKTHTAVKISPRYPH-PVVHCLDASKSVVVCSSLSDMSVRDAFLQ 2691
R G +IPLLIGGATTS+ HTAVKI RY V+ +DAS++V V S+L + A++
Sbjct: 847 REGFDIPLLIGGATTSRVHTAVKIHSRYERGQAVYVVDASRAVGVVSNLLSPEGKQAYID 906
Query: 2692 DLNEDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNE 2871
L +Y V H + +++ + + R ++DW+ + VKP+F G + ++ +DL E
Sbjct: 907 GLRNEYAKVAAAHARNEAEKQRLPIARARANPHQLDWENYEPVKPTFTGTKVFETYDLAE 966
Query: 2872 LIPYIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVA 3051
+ YIDW PFF W+LRG+ YP I +D G A++++ DAQ L+K+IDEK
Sbjct: 967 IARYIDWTPFFQTWELRGR-----YPAILEDEKQGEAARQLWADAQAMLRKIIDEKWFTP 1021
Query: 3052 NAVVSFLPAASEGDDMHVY-DPETGNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGV 3228
AVV F PA + GDD+ ++ D +L T + LRQQ + +P+ ++DF+ P+++G
Sbjct: 1022 RAVVGFWPANAVGDDIRLFTDESRKEELATLFTLRQQLTKRDGRPNVAMADFVAPVESG- 1080
Query: 3229 PDDYLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWG 3408
DY+G F TAG+G + E+ +DDY++I+VKALADR AEA+AE +H+ VR W
Sbjct: 1081 KQDYVGGFVVTAGIGEIAIAERFERANDDYSAILVKALADRFAEAFAELMHERVRKEFWA 1140
Query: 3409 YSTNEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKN-GIGLTEHLAMLP 3585
Y+ +E T +L+S Y+GIRPA GYP+QPDHTEK TL++LL+A N G+ LTE AM P
Sbjct: 1141 YAPDEAFTPEELISEPYKGIRPAPGYPAQPDHTEKTTLFRLLDATANTGVELTESYAMWP 1200
Query: 3586 AASVSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGY 3738
+SVSGLY +P+S YF V K+++DQV DYA RK++ E VERWL+PIL Y
Sbjct: 1201 GSSVSGLYIGHPESYYFGVAKVERDQVEDYARRKDMDVEAVERWLTPILNY 1251
>gi|23472268|ref|ZP_00127595.1| COG1410: Methionine synthase I,
cobalamin-binding domain [Pseudomonas syringae pv.
syringae B728a]
Length = 1239
Score = 1249 bits (3232), Expect = 0.0
Identities = 655/1258 (52%), Positives = 855/1258 (67%), Gaps = 13/1258 (1%)
Frame = +1
Query: 7 RSSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITR 186
RS+ + K+RI+I+DG MGTMIQ +EE+D+RG+ D +KGNNDLL +TR
Sbjct: 4 RSARHQAFLTALKQRILILDGGMGTMIQSYRLEEQDYRGKRFADWPSDVKGNNDLLILTR 63
Query: 187 PDIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGA 366
PD+I I K YL+AGAD +ETNTF+ T ++QADY E +V+E+N + A +AR+ D
Sbjct: 64 PDVIGAIEKAYLDAGADILETNTFNATQVSQADYGMESIVYELNVEGARLARKVADAKTL 123
Query: 367 AT-GRRRYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLV 543
T R R+V G +GPT+RT S+SP V P +RNVTF ELV+ Y + + LI+GG D++L+
Sbjct: 124 ETPDRPRFVAGVLGPTSRTCSLSPDVNNPGYRNVTFDELVENYTEATKGLIEGGADLILI 183
Query: 544 ETVFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGK 723
ET+FD+ NAKAA+FA++ +FE+ G E+P+ +SGTI D SGRTLSGQT EAF S K
Sbjct: 184 ETIFDTLNAKAAIFAVQGVFEEVGF-ELPIMISGTITDASGRTLSGQTTEAFWNSISHAK 242
Query: 724 PMAVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFA 903
P++VGLNCALGA ++R ++ ++ +++ + +PNAGLPNA G YDE P + A ++ EFA
Sbjct: 243 PISVGLNCALGASELRPYLQELANKANTHVSAHPNAGLPNAFGEYDELPSQTAKIIEEFA 302
Query: 904 RDGLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFV 1083
+ G +NI+GGCCGTTP HI A+ +AV G PR P P A + LSGLEP + ++ FV
Sbjct: 303 QSGFLNIVGGCCGTTPAHIKAIAEAVSGYAPREIPDIPKACR--LSGLEPFTIDRQSLFV 360
Query: 1084 NIGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFL 1263
N+GER N+ GS RF LI+ +NY A++VA QV++GAQ++D+NMD+G+LD AM FL
Sbjct: 361 NVGERTNITGSARFARLIREDNYTEALEVALQQVEAGAQVIDINMDEGMLDSKKAMVTFL 420
Query: 1264 RLISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYG 1443
LI+ EPD++++P+ IDSS ++VI AGL+ QGK +VNSIS+KEG E+F AR+ KRYG
Sbjct: 421 NLIAGEPDISRVPIMIDSSKWEVIEAGLKCIQGKGIVNSISMKEGVEQFIHHARLCKRYG 480
Query: 1444 AAVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSN 1623
AAVVVMAFDEQGQA K EIC+RSY IL +EVGF P DIIFD NI IATG+EEH+N
Sbjct: 481 AAVVVMAFDEQGQADTEARKKEICKRSYDILVDEVGFPPEDIIFDPNIFAIATGIEEHNN 540
Query: 1624 YGMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIV 1803
Y + FI A IR+ LP A SGGVSN+SFSFRG +REA+HSVFL +AI+ G+ MGIV
Sbjct: 541 YAVDFINACAYIRDELPYALTSGGVSNVSFSFRGNNPVREAIHSVFLLHAIRNGLSMGIV 600
Query: 1804 NAGALPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEMXXXXXXXXXXXXEWRSLTV 1983
NAG L +Y+ I NR+PE T+ LL A + EWRS V
Sbjct: 601 NAGQLEIYDQIPAELRDCVEDVVLNRNPEGTDALLAIADKFKGDGSVKEAETEEWRSWPV 660
Query: 1984 EERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFLP 2163
+RL+ ALVKG+ +V DTEE+R + RP+ VIE PLM GM VVG+LFGAGKMFLP
Sbjct: 661 NQRLEHALVKGITTHIVQDTEESR---VGFARPIEVIEGPLMAGMNVVGDLFGAGKMFLP 717
Query: 2164 QVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKNI 2343
QV+KSARVMK+AVAHL+PF+E+E+ D+ +G +++ATVKGDVHDIGKNI
Sbjct: 718 QVVKSARVMKQAVAHLIPFIELEK----------GDKPEAKGKILMATVKGDVHDIGKNI 767
Query: 2344 VSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRVG 2523
V VVLGCN + +VDLGVM P E I++ A +EK D IGLSGLITPSLDEMV+VA+EM R
Sbjct: 768 VGVVLGCNGYDIVDLGVMVPAEKILQVARDEKCDIIGLSGLITPSLDEMVHVAREMQRQD 827
Query: 2524 LNIPLLIGGATTSKTHTAVKISPRYPH-PVVHCLDASKSVVVCSSLSDMSVRDAFLQDLN 2700
++PL+IGGATTSK HTAVKI P+Y + V++ DAS++V V + L ++ AF++
Sbjct: 828 FHLPLMIGGATTSKAHTAVKIEPKYSNDAVIYVTDASRAVGVATQLLSKELKPAFIEKTR 887
Query: 2701 EDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIP 2880
+Y +VR+ A KK + DW+ +T +P+F G R Q+ DLN L
Sbjct: 888 LEYVEVRERTSARSARTERLSYGAAVAKKPQFDWENYTPAQPTFTGTRVLQDIDLNVLAE 947
Query: 2881 YIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAV 3060
YIDW PFF W L GK YP+I D VG A ++ DA L+KLIDEK++ A AV
Sbjct: 948 YIDWTPFFISWDLAGK-----YPRILTDEVVGEAATALYADATQMLRKLIDEKLISARAV 1002
Query: 3061 VSFLPAAS-EGDDMHVYDPETGNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDD 3237
F PA DD+ VYD + G L + LRQQ+ + +P+F L+DF+ P +G+ D
Sbjct: 1003 FGFWPANQVNDDDLEVYD-DDGKPLAKLHHLRQQTIKPDGKPNFSLADFVAPKDSGL-TD 1060
Query: 3238 YLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYST 3417
Y+G F TAG+GAEE K + DDY SIMVKALADRLAEA AE+LH++VR WGY+
Sbjct: 1061 YIGGFITTAGIGAEEVAKAYQDKGDDYNSIMVKALADRLAEACAEWLHQQVRKEYWGYAQ 1120
Query: 3418 NEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLE----------AEKNGIGLTE 3567
+E L L+ +Y GIRPA GYP+ PDHTEK TL+ LL+ A K+G+ LTE
Sbjct: 1121 DEALDNEALIKEQYMGIRPAPGYPACPDHTEKGTLFALLDPLPEGSAEHTAGKSGVFLTE 1180
Query: 3568 HLAMLPAASVSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGYD 3741
H AM PAA+VSG YFA+PQ++YFAVGKID+DQV Y ARK ERWL+P LGYD
Sbjct: 1181 HYAMFPAAAVSGWYFAHPQAQYFAVGKIDKDQVESYTARKGQDLSVTERWLAPNLGYD 1238
>gi|23501099|ref|NP_697226.1| 5-methyltetrahydrofolate--homocysteine
methyltransferase [Brucella suis 1330]
gi|23346969|gb|AAN29141.1| 5-methyltetrahydrofolate--homocysteine
methyltransferase [Brucella suis 1330]
Length = 1261
Score = 1249 bits (3231), Expect = 0.0
Identities = 657/1251 (52%), Positives = 858/1251 (68%), Gaps = 8/1251 (0%)
Frame = +1
Query: 10 SSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRP 189
S + L + A+ERI+I+DGAMGT IQ EE FRG+ D L+GNNDLL++T+P
Sbjct: 19 SEVLAALTQAARERILILDGAMGTQIQGLGFHEEHFRGDRFATCDCQLQGNNDLLTLTQP 78
Query: 190 DIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAA 369
I +IH Y AGAD +ETNTFS T+IAQADY E +V+++N A +ARRA
Sbjct: 79 KAIEEIHYAYAMAGADILETNTFSSTSIAQADYGMEAMVYDLNRDGARLARRAALRAEQK 138
Query: 370 TGRRRYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVET 549
GRRR+V GA+GPTNRT S+SP V P FR VTF +L AY +Q R LI GG D++L+ET
Sbjct: 139 DGRRRFVAGALGPTNRTASLSPDVNNPGFRAVTFDDLRIAYSEQIRGLIDGGSDIILIET 198
Query: 550 VFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKPM 729
+FD+ NAKAA+FA +F ++GV +PV +SGTI D+SGRTLSGQT AF S + +P
Sbjct: 199 IFDTLNAKAAVFATEEVFAEKGV-RLPVMISGTITDLSGRTLSGQTPTAFWYSLRHARPF 257
Query: 730 AVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFARD 909
+GLNCALGA MR ++ +S +D+FI YPNAGLPN G YDETPE MA + FARD
Sbjct: 258 TIGLNCALGANAMRAHLNELSGIADTFICAYPNAGLPNEFGQYDETPEAMAAQIEGFARD 317
Query: 910 GLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVNI 1089
GLVN++GGCCG+TPDHI A+ +AV PR P + P M LSGLEP + + FVNI
Sbjct: 318 GLVNVVGGCCGSTPDHIRAIAQAVAKYEPRKPAKVPPL--MRLSGLEPFTLTKDIPFVNI 375
Query: 1090 GERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLRL 1269
GER NV GS RF L+K ++ A+DVAR QV +GAQI+D+NMD+GL+D AM +FL L
Sbjct: 376 GERTNVTGSARFRKLVKAGDFAAALDVARDQVANGAQIIDINMDEGLIDSEKAMVEFLNL 435
Query: 1270 ISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGAA 1449
I++EPD+A++P+ +DSS ++VI AGL+ QGK VVNSISLKEGEE F AR+++ YGAA
Sbjct: 436 IAAEPDIARVPIMLDSSKWEVIEAGLKCVQGKAVVNSISLKEGEEAFLHHARLVRAYGAA 495
Query: 1450 VVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNYG 1629
VV+MAFDE GQA K EIC R+Y+ILTE+VGF P DIIFD NI +ATG+EEH+NYG
Sbjct: 496 VVIMAFDETGQADTQARKIEICTRAYKILTEQVGFPPEDIIFDPNIFAVATGIEEHNNYG 555
Query: 1630 MYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVNA 1809
+ FIEA R I LP H+SGGVSN+SFSFRG E +REAMH+VFL++AI+AGMDMGIVNA
Sbjct: 556 VDFIEATREIVRTLPHVHISGGVSNLSFSFRGNEPVREAMHAVFLYHAIQAGMDMGIVNA 615
Query: 1810 GALPVYEDIDKPXXXXXXXXXFNRDPE----ATEKLL-VAAQEMXXXXXXXXXXXXEWRS 1974
G L VY+ ID NR + ATE+LL +A + WR
Sbjct: 616 GQLAVYDTIDAELREACEDVVLNRPTKTGESATERLLEIAERFRDSGSREARTQDLSWRE 675
Query: 1975 LTVEERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKM 2154
VE+RL+ ALV G+ +++ ADTEEAR RPL+VIE PLM GM VVG+LFG+GKM
Sbjct: 676 WPVEKRLEHALVNGITEYIEADTEEAR---LAAERPLHVIEGPLMAGMNVVGDLFGSGKM 732
Query: 2155 FLPQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIG 2334
FLPQV+KSARVMK+AVA LLPFME E++ N + G V++ATVKGDVHDIG
Sbjct: 733 FLPQVVKSARVMKQAVAVLLPFMEEEKRLN------GGEGRQSAGKVLMATVKGDVHDIG 786
Query: 2335 KNIVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMN 2514
KNIV VVL CNN++++DLGVM P + I++ A +EK D IGLSGLITPSLDEM +VA EM
Sbjct: 787 KNIVGVVLACNNYEIIDLGVMVPSQKILQVARDEKVDIIGLSGLITPSLDEMAHVAAEME 846
Query: 2515 RVGLNIPLLIGGATTSKTHTAVKISPRYPH-PVVHCLDASKSVVVCSSLSDMSVRDAFLQ 2691
R G +IPLLIGGATTS+ HTAVKI RY V+ +DAS++V V S+L + A++
Sbjct: 847 REGFDIPLLIGGATTSRVHTAVKIHSRYERGQAVYVVDASRAVGVVSNLLSPEGKQAYID 906
Query: 2692 DLNEDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNE 2871
L +Y V H + +++ + + R ++DW+ + VKP+F G + ++ +DL E
Sbjct: 907 GLRNEYAKVAAAHARNEAEKQRLPIARARANPHQLDWENYEPVKPAFTGTKVFETYDLAE 966
Query: 2872 LIPYIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVA 3051
+ YIDW PFF W+LRG+ YP I +D G A++++ DAQ L+K+IDEK
Sbjct: 967 IARYIDWTPFFQTWELRGR-----YPAILEDEKQGEAARQLWADAQAMLRKIIDEKWFTP 1021
Query: 3052 NAVVSFLPAASEGDDMHVY-DPETGNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGV 3228
AVV F PA + GDD+ ++ D +L T + LRQQ + +P+ ++DF+ P+++G
Sbjct: 1022 RAVVGFWPANAVGDDIRLFTDESRKEELATLFTLRQQLTKRDGRPNVAMADFVAPVESG- 1080
Query: 3229 PDDYLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWG 3408
DY+G F TAG+G + E+ +DDY++I+VKALADR AEA+AE +H+ VR W
Sbjct: 1081 KQDYVGGFVVTAGIGEIAITERFERANDDYSAILVKALADRFAEAFAELMHERVRKEFWA 1140
Query: 3409 YSTNEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKN-GIGLTEHLAMLP 3585
Y+ +E T +L+S Y+GIRPA GYP+QPDHTEK TL++LL+A N G+ LTE AM P
Sbjct: 1141 YAPDEAFTPEELISEPYKGIRPAPGYPAQPDHTEKTTLFRLLDATANTGVELTESYAMWP 1200
Query: 3586 AASVSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGY 3738
+SVSGLY +P+S YF V K+++DQV DYA RK++ E VERWL+PIL Y
Sbjct: 1201 GSSVSGLYIGHPESYYFGVAKVERDQVEDYARRKDMDVEAVERWLTPILNY 1251
>gi|16422743|gb|AAL23012.1| B12-dependent
homocysteine-N5-methyltetrahydrofolate transmethylase
[Salmonella typhimurium LT2]
Length = 1256
Score = 1248 bits (3228), Expect = 0.0
Identities = 661/1251 (52%), Positives = 851/1251 (67%), Gaps = 5/1251 (0%)
Frame = +1
Query: 10 SSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRP 189
SS E+L ERI+++DG MGTMIQ + EEDFRGE D LKGNNDLL +++P
Sbjct: 31 SSKVEQLRAQLNERILVLDGGMGTMIQSYRLHEEDFRGERFADWPCDLKGNNDLLVLSKP 90
Query: 190 DIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAA 369
++I IH Y EAGAD +ETNTF+ TTIA ADYR E L EINY +A +AR D+ A
Sbjct: 91 EVIAAIHNAYFEAGADIIETNTFNSTTIAMADYRMESLSAEINYAAAKLARACADEWTAR 150
Query: 370 TGRR-RYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVE 546
T + R+V G +GPTNRT SISP V P FRN+TF +LV AY + ++L++GG D++L+E
Sbjct: 151 TPEKPRFVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGADLILIE 210
Query: 547 TVFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKP 726
TVFD+ NAKAA+FA++ FE GV ++P+ +SGTI D SGRTLSGQT EAF S + +
Sbjct: 211 TVFDTLNAKAAVFAVKEEFEALGV-DLPIMISGTITDASGRTLSGQTTEAFYNSLRHAEA 269
Query: 727 MAVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFAR 906
+ GLNCALG ++RQ+V +S+ ++ ++ +PNAGLPNA G YD + MA +RE+A
Sbjct: 270 LTFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAE 329
Query: 907 DGLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVN 1086
G +NI+GGCCGTTP+HI AM +AV G+ PR P P A + LSGLEP +G ++ FVN
Sbjct: 330 AGFLNIVGGCCGTTPEHIAAMSRAVAGLLPRQLPDIPVACR--LSGLEPLNIGDDSLFVN 387
Query: 1087 IGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLR 1266
+GER NV GS +F LIK E Y A+DVAR QV+SGAQI+D+NMD+G+LD AM +FL
Sbjct: 388 VGERTNVTGSAKFKRLIKEEKYSEALDVARQQVESGAQIIDINMDEGMLDAEAAMVRFLS 447
Query: 1267 LISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGA 1446
LI+ EPD+A++P+ IDSS ++VI GL+ QGK +VNSIS+KEG E F A++++RYGA
Sbjct: 448 LIAGEPDIARVPIMIDSSKWEVIEKGLKCIQGKGIVNSISMKEGVEAFIHHAKLLRRYGA 507
Query: 1447 AVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNY 1626
AVVVMAFDEQGQA K EIC R+Y+ILTEEVGF P DIIFD NI +ATG+EEH+NY
Sbjct: 508 AVVVMAFDEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNY 567
Query: 1627 GMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVN 1806
FI A I+ LP A +SGGVSN+SFSFRG + +REA+H+VFL+YAI+ GMDMGIVN
Sbjct: 568 AQDFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVN 627
Query: 1807 AGALPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEM--XXXXXXXXXXXXEWRSLT 1980
AG L +Y+D+ NR + TE+LL A++ EWRS
Sbjct: 628 AGQLAIYDDLPAELRDAVEDVILNRRDDGTERLLDLAEKYRGSKTDEAANAQQAEWRSWD 687
Query: 1981 VEERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFL 2160
V++RL+++LVKG+ +F+ DTEEARQ A RP+ VIE PLMDGM VVG+LFG GKMFL
Sbjct: 688 VKKRLEYSLVKGITEFIEQDTEEARQQAA---RPIEVIEGPLMDGMNVVGDLFGEGKMFL 744
Query: 2161 PQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKN 2340
PQV+KSARVMK+AVA+L PF+E ++++ G +VIATVKGDVHDIGKN
Sbjct: 745 PQVVKSARVMKQAVAYLEPFIE-----------ASKEKGSSNGKMVIATVKGDVHDIGKN 793
Query: 2341 IVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRV 2520
IV VVL CNN+++VDLGVM P E I++ A E AD IGLSGLITPSLDEMV VAKEM R
Sbjct: 794 IVGVVLQCNNYEIVDLGVMVPAEKILRTAREVNADLIGLSGLITPSLDEMVNVAKEMERQ 853
Query: 2521 GLNIPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLN 2700
G IPLLIGGATTSK HTAVKI Y P V+ +AS++V V ++L + RD F+
Sbjct: 854 GFTIPLLIGGATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTR 913
Query: 2701 EDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIP 2880
++YE VR +H L R+ DW+++T +G +E + + L
Sbjct: 914 KEYETVRIQHARKKPRTPPVTLEAARDNDLAFDWERYTPPVAHRLGVQEVE-ASIETLRN 972
Query: 2881 YIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAV 3060
YIDW PFF W L GK YP+I +D VG EA+++F DA L KL EK+L V
Sbjct: 973 YIDWTPFFMTWSLAGK-----YPRILEDEVVGVEAQRLFKDANDMLDKLSAEKLLNPRGV 1027
Query: 3061 VSFLPAASEGDDMHVYDPET-GNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDD 3237
V PA GDD+ +Y ET + L + LRQQ+ + ++CL+DF+ P +G D
Sbjct: 1028 VGLFPANRVGDDIEIYRDETRTHVLTVSHHLRQQT-EKVGFANYCLADFVAPKLSG-KAD 1085
Query: 3238 YLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYST 3417
Y+G FA T GL + E HDDY IMVKA+ADRLAEA+AEYLH+ VR WGY+
Sbjct: 1086 YIGAFAVTGGLEEDALADAFEAQHDDYNKIMVKAIADRLAEAFAEYLHERVRKVYWGYAP 1145
Query: 3418 NEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKN-GIGLTEHLAMLPAAS 3594
NE L+ +L+ YQGIRPA GYP+ P+HTEK T+W+LL+ EK+ G+ LTE AM P AS
Sbjct: 1146 NESLSNDELIRENYQGIRPAPGYPACPEHTEKGTIWQLLDVEKHTGMKLTESFAMWPGAS 1205
Query: 3595 VSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGYDTD 3747
VSG YF++P+S+YFAV +I +DQV DYA RK + E+VERWL+P LGYD D
Sbjct: 1206 VSGWYFSHPESKYFAVAQIQRDQVTDYAFRKGMSVEDVERWLAPNLGYDAD 1256
>gi|39546391|ref|NP_463053.2| B12-dependent
homocysteine-N5-methyltetrahydrofolate transmethylase
[Salmonella typhimurium LT2]
gi|17865736|sp|P37586|METH_SALTY Methionine synthase
(5-methyltetrahydrofolate--homocysteine
methyltransferase) (Methionine synthase, vitamin-B12
dependent isozyme) (MS)
Length = 1227
Score = 1248 bits (3228), Expect = 0.0
Identities = 661/1251 (52%), Positives = 851/1251 (67%), Gaps = 5/1251 (0%)
Frame = +1
Query: 10 SSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRP 189
SS E+L ERI+++DG MGTMIQ + EEDFRGE D LKGNNDLL +++P
Sbjct: 2 SSKVEQLRAQLNERILVLDGGMGTMIQSYRLHEEDFRGERFADWPCDLKGNNDLLVLSKP 61
Query: 190 DIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAA 369
++I IH Y EAGAD +ETNTF+ TTIA ADYR E L EINY +A +AR D+ A
Sbjct: 62 EVIAAIHNAYFEAGADIIETNTFNSTTIAMADYRMESLSAEINYAAAKLARACADEWTAR 121
Query: 370 TGRR-RYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVE 546
T + R+V G +GPTNRT SISP V P FRN+TF +LV AY + ++L++GG D++L+E
Sbjct: 122 TPEKPRFVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGADLILIE 181
Query: 547 TVFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKP 726
TVFD+ NAKAA+FA++ FE GV ++P+ +SGTI D SGRTLSGQT EAF S + +
Sbjct: 182 TVFDTLNAKAAVFAVKEEFEALGV-DLPIMISGTITDASGRTLSGQTTEAFYNSLRHAEA 240
Query: 727 MAVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFAR 906
+ GLNCALG ++RQ+V +S+ ++ ++ +PNAGLPNA G YD + MA +RE+A
Sbjct: 241 LTFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAE 300
Query: 907 DGLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVN 1086
G +NI+GGCCGTTP+HI AM +AV G+ PR P P A + LSGLEP +G ++ FVN
Sbjct: 301 AGFLNIVGGCCGTTPEHIAAMSRAVAGLLPRQLPDIPVACR--LSGLEPLNIGDDSLFVN 358
Query: 1087 IGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLR 1266
+GER NV GS +F LIK E Y A+DVAR QV+SGAQI+D+NMD+G+LD AM +FL
Sbjct: 359 VGERTNVTGSAKFKRLIKEEKYSEALDVARQQVESGAQIIDINMDEGMLDAEAAMVRFLS 418
Query: 1267 LISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGA 1446
LI+ EPD+A++P+ IDSS ++VI GL+ QGK +VNSIS+KEG E F A++++RYGA
Sbjct: 419 LIAGEPDIARVPIMIDSSKWEVIEKGLKCIQGKGIVNSISMKEGVEAFIHHAKLLRRYGA 478
Query: 1447 AVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNY 1626
AVVVMAFDEQGQA K EIC R+Y+ILTEEVGF P DIIFD NI +ATG+EEH+NY
Sbjct: 479 AVVVMAFDEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNY 538
Query: 1627 GMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVN 1806
FI A I+ LP A +SGGVSN+SFSFRG + +REA+H+VFL+YAI+ GMDMGIVN
Sbjct: 539 AQDFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVN 598
Query: 1807 AGALPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEM--XXXXXXXXXXXXEWRSLT 1980
AG L +Y+D+ NR + TE+LL A++ EWRS
Sbjct: 599 AGQLAIYDDLPAELRDAVEDVILNRRDDGTERLLDLAEKYRGSKTDEAANAQQAEWRSWD 658
Query: 1981 VEERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFL 2160
V++RL+++LVKG+ +F+ DTEEARQ A RP+ VIE PLMDGM VVG+LFG GKMFL
Sbjct: 659 VKKRLEYSLVKGITEFIEQDTEEARQQAA---RPIEVIEGPLMDGMNVVGDLFGEGKMFL 715
Query: 2161 PQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKN 2340
PQV+KSARVMK+AVA+L PF+E ++++ G +VIATVKGDVHDIGKN
Sbjct: 716 PQVVKSARVMKQAVAYLEPFIE-----------ASKEKGSSNGKMVIATVKGDVHDIGKN 764
Query: 2341 IVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRV 2520
IV VVL CNN+++VDLGVM P E I++ A E AD IGLSGLITPSLDEMV VAKEM R
Sbjct: 765 IVGVVLQCNNYEIVDLGVMVPAEKILRTAREVNADLIGLSGLITPSLDEMVNVAKEMERQ 824
Query: 2521 GLNIPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLN 2700
G IPLLIGGATTSK HTAVKI Y P V+ +AS++V V ++L + RD F+
Sbjct: 825 GFTIPLLIGGATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTR 884
Query: 2701 EDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIP 2880
++YE VR +H L R+ DW+++T +G +E + + L
Sbjct: 885 KEYETVRIQHARKKPRTPPVTLEAARDNDLAFDWERYTPPVAHRLGVQEVE-ASIETLRN 943
Query: 2881 YIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAV 3060
YIDW PFF W L GK YP+I +D VG EA+++F DA L KL EK+L V
Sbjct: 944 YIDWTPFFMTWSLAGK-----YPRILEDEVVGVEAQRLFKDANDMLDKLSAEKLLNPRGV 998
Query: 3061 VSFLPAASEGDDMHVYDPET-GNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDD 3237
V PA GDD+ +Y ET + L + LRQQ+ + ++CL+DF+ P +G D
Sbjct: 999 VGLFPANRVGDDIEIYRDETRTHVLTVSHHLRQQT-EKVGFANYCLADFVAPKLSG-KAD 1056
Query: 3238 YLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYST 3417
Y+G FA T GL + E HDDY IMVKA+ADRLAEA+AEYLH+ VR WGY+
Sbjct: 1057 YIGAFAVTGGLEEDALADAFEAQHDDYNKIMVKAIADRLAEAFAEYLHERVRKVYWGYAP 1116
Query: 3418 NEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKN-GIGLTEHLAMLPAAS 3594
NE L+ +L+ YQGIRPA GYP+ P+HTEK T+W+LL+ EK+ G+ LTE AM P AS
Sbjct: 1117 NESLSNDELIRENYQGIRPAPGYPACPEHTEKGTIWQLLDVEKHTGMKLTESFAMWPGAS 1176
Query: 3595 VSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGYDTD 3747
VSG YF++P+S+YFAV +I +DQV DYA RK + E+VERWL+P LGYD D
Sbjct: 1177 VSGWYFSHPESKYFAVAQIQRDQVTDYAFRKGMSVEDVERWLAPNLGYDAD 1227
>gi|304910|gb|AAA02995.1| methionine synthase
Length = 1227
Score = 1247 bits (3226), Expect = 0.0
Identities = 661/1251 (52%), Positives = 849/1251 (67%), Gaps = 5/1251 (0%)
Frame = +1
Query: 10 SSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRP 189
SS E+L ERI+++DG MGTMIQ + E DFRGE D LKGNNDLL +++P
Sbjct: 2 SSKVEQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSKP 61
Query: 190 DIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAA 369
++I IH Y EAGAD +ETNTF+ TTIA ADY+ E L EIN+ +A +ARR D+ A
Sbjct: 62 EVIAAIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARRCADEWTAR 121
Query: 370 TGRR-RYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVE 546
T + RYV G +GPTNRT SISP V P FRN+TF LV AY + ++L++GG D++L+E
Sbjct: 122 TPEKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDGLVAAYRESTKALVEGGADLILIE 181
Query: 547 TVFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKP 726
TVFD+ NAKAA+FA++T FE GV E+P+ +SGTI D SGRTLSGQT EAF S + +
Sbjct: 182 TVFDTLNAKAAVFAVKTEFEALGV-ELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEA 240
Query: 727 MAVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFAR 906
+ GLNCALG ++RQ+V +S+ ++ ++ +PNAGLPNA G YD + MA +RE+A+
Sbjct: 241 LTFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAQ 300
Query: 907 DGLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVN 1086
G +NI+GGCCGTTP HI AM +AV+G+ PR P+ P A + LSGLEP +G ++ FVN
Sbjct: 301 AGFLNIVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACR--LSGLEPLNIGEDSLFVN 358
Query: 1087 IGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLR 1266
+GER NV GS +F LIK E Y A+DVAR QV++GAQI+D+NMD+G+LD AM +FL
Sbjct: 359 VGERTNVTGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLN 418
Query: 1267 LISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGA 1446
LI+ EPD+A++P+ IDSS +DVI GL+ QGK +VNSIS+KEG + F A++++RYGA
Sbjct: 419 LIAGEPDIARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGA 478
Query: 1447 AVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNY 1626
AVVVMAFDEQGQA K EIC R+Y+ILTEEVGF P DIIFD NI +ATG+EEH+NY
Sbjct: 479 AVVVMAFDEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNY 538
Query: 1627 GMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVN 1806
FI A I+ LP A +SGGVSN+SFSFRG + +REA+H+VFL+YAI+ GMDMGIVN
Sbjct: 539 AQDFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVN 598
Query: 1807 AGALPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEM--XXXXXXXXXXXXEWRSLT 1980
AG L +Y+D+ NR + TE+LL A++ EWRS
Sbjct: 599 AGQLAIYDDLPAELRDAVEDVILNRRDDGTERLLELAEKYRGTKTDDTANAQQAEWRSWE 658
Query: 1981 VEERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFL 2160
V +RL+++LVKG+ +F+ DTEEARQ RP+ VIE PLMDGM VVG+LFG GKMFL
Sbjct: 659 VNKRLEYSLVKGITEFIEQDTEEARQQAT---RPIEVIEGPLMDGMNVVGDLFGEGKMFL 715
Query: 2161 PQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKN 2340
PQV+KSARVMK+AVA+L PF+E ++++ G +VIATVKGDVHDIGKN
Sbjct: 716 PQVVKSARVMKQAVAYLEPFIE-----------ASKEQGKTNGKMVIATVKGDVHDIGKN 764
Query: 2341 IVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRV 2520
IV VVL CNN+++VDLGVM P E I++ A E AD IGLSGLITPSLDEMV VAKEM R
Sbjct: 765 IVGVVLQCNNYEIVDLGVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQ 824
Query: 2521 GLNIPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLN 2700
G IPLLIGGATTSK HTAVKI Y P V+ +AS++V V ++L + RD F+
Sbjct: 825 GFTIPLLIGGATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTR 884
Query: 2701 EDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIP 2880
++YE VR +H L R+ F DW +T +G +E + + L
Sbjct: 885 KEYETVRIQHGRKKPRTPPVTLEAARDNDFAFDWQAYTPPVAHRLGVQEVE-ASIETLRN 943
Query: 2881 YIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAV 3060
YIDW PFF W L GK YP+I +D VG EA+++F DA L KL EK L V
Sbjct: 944 YIDWTPFFMTWSLAGK-----YPRILEDEVVGVEAQRLFKDANDMLDKLSAEKTLNPRGV 998
Query: 3061 VSFLPAASEGDDMHVYDPET-GNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDD 3237
V PA GDD+ +Y ET + ++ + LRQQ+ + ++CL+DF+ P +G D
Sbjct: 999 VGLFPANRVGDDIEIYRDETRTHVINVSHHLRQQT-EKTGFANYCLADFVAPKLSG-KAD 1056
Query: 3238 YLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYST 3417
Y+G FA T GL + E HDDY IMVKALADRLAEA+AEYLH+ VR WGY+
Sbjct: 1057 YIGAFAVTGGLEEDALADAFEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAP 1116
Query: 3418 NEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKN-GIGLTEHLAMLPAAS 3594
NE+L+ +L+ YQGIRPA GYP+ P+HTEK T+W+LLE EK+ G+ LTE AM P AS
Sbjct: 1117 NENLSNEELIRENYQGIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGAS 1176
Query: 3595 VSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGYDTD 3747
VSG YF++P S+Y+AV +I +DQV DYA RK + EVERWL+P LGYD D
Sbjct: 1177 VSGWYFSHPDSKYYAVAQIQRDQVEDYARRKGMSVTEVERWLAPNLGYDAD 1227
>gi|16762890|ref|NP_458507.1| B12-dependent
homocysteine-N5-methyltetrahydrofolate transmethylase
[Salmonella enterica subsp. enterica serovar Typhi str.
CT18]
gi|29144377|ref|NP_807719.1| B12-dependent
homocysteine-N5-methyltetrahydrofolate transmethylase
[Salmonella enterica subsp. enterica serovar Typhi Ty2]
gi|25285956|pir||AH1011 5-methyltetrahydrofolate-homocysteine
S-methyltransferase (EC 2.1.1.13) - Salmonella enterica
subsp. enterica serovar Typhi (strain CT18)
gi|16505197|emb|CAD09193.1| B12-dependent
homocysteine-N5-methyltetrahydrofolate transmethylase
[Salmonella enterica subsp. enterica serovar Typhi]
gi|29140015|gb|AAO71579.1| B12-dependent
homocysteine-N5-methyltetrahydrofolate transmethylase
[Salmonella enterica subsp. enterica serovar Typhi Ty2]
Length = 1227
Score = 1246 bits (3224), Expect = 0.0
Identities = 659/1251 (52%), Positives = 852/1251 (67%), Gaps = 5/1251 (0%)
Frame = +1
Query: 10 SSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRP 189
SS E+L ERI+++DG MGTMIQ + EEDFRGE D LKGNNDLL +++P
Sbjct: 2 SSKVEQLRAQLNERILVLDGGMGTMIQSYRLHEEDFRGERFADWPCDLKGNNDLLVLSKP 61
Query: 190 DIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAA 369
++I IH Y EAGAD +ETNTF+ TTIA ADYR E L EINY +A +AR D+ A
Sbjct: 62 EVIAAIHNAYFEAGADIIETNTFNSTTIAMADYRMESLSAEINYAAAKLARACADEWTAR 121
Query: 370 TGRR-RYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVE 546
T + R+V G +GPTNRT SISP V P FRN+TF +LV AY + ++L++GG D++L+E
Sbjct: 122 TPEKPRFVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGADLILIE 181
Query: 547 TVFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKP 726
TVFD+ NAKAA+FA++ FE GV ++P+ +SGTI D SGRTLSGQT EAF S + +
Sbjct: 182 TVFDTLNAKAAVFAVKEEFEALGV-DLPIMISGTITDASGRTLSGQTTEAFYNSLRHAEA 240
Query: 727 MAVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFAR 906
+ GLNCALG ++RQ+V +S+ ++ ++ +PNAGLPNA G YD + MA +RE+A
Sbjct: 241 LTFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAE 300
Query: 907 DGLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVN 1086
G +NI+GGCCGTTP+HI AM +AV G++PR P P A + LSGLEP +G ++ FVN
Sbjct: 301 AGFLNIVGGCCGTTPEHIAAMSRAVAGLSPRQLPDIPVACR--LSGLEPLNIGDDSLFVN 358
Query: 1087 IGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLR 1266
+GER NV GS +F LIK E Y A+DVAR QV+SGAQI+D+NMD+G+LD AM +FL
Sbjct: 359 VGERTNVTGSAKFKRLIKEEKYSEALDVARQQVESGAQIIDINMDEGMLDAEAAMVRFLS 418
Query: 1267 LISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGA 1446
LI+ EPD+A++P+ IDSS ++VI GL+ QGK +VNSIS+KEG E F A++++RYGA
Sbjct: 419 LIAGEPDIARVPIMIDSSKWEVIEKGLKCIQGKGIVNSISMKEGVEAFIHHAKLLRRYGA 478
Query: 1447 AVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNY 1626
AVVVMAFDEQGQA + K EIC R+Y+IL EEVGF P DIIFD NI +ATG+EEH+NY
Sbjct: 479 AVVVMAFDEQGQADTRERKIEICRRAYKILLEEVGFPPEDIIFDPNIFAVATGIEEHNNY 538
Query: 1627 GMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVN 1806
FI A I+ LP A +SGGVSN+SFSFRG + +REA+H+VFL+YAI+ GMDMGIVN
Sbjct: 539 AQDFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVN 598
Query: 1807 AGALPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEM--XXXXXXXXXXXXEWRSLT 1980
AG L +Y+++ NR + TE+LL A++ EWRS
Sbjct: 599 AGQLAIYDNLPAELRDAVEDVILNRRDDGTERLLDLAEKYRGSKTDEAASAQQAEWRSWD 658
Query: 1981 VEERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFL 2160
V++RL+++LVKG+ +F+ DTEEARQ A RP+ VIE PLMDGM VVG+LFG GKMFL
Sbjct: 659 VKKRLEYSLVKGITEFIEQDTEEARQQAA---RPIEVIEGPLMDGMNVVGDLFGEGKMFL 715
Query: 2161 PQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKN 2340
PQV+KSARVMK+AVA+L PF+E ++++ G +VIATVKGDVHDIGKN
Sbjct: 716 PQVVKSARVMKQAVAYLEPFIE-----------ASKEKGSSNGKMVIATVKGDVHDIGKN 764
Query: 2341 IVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRV 2520
IV VVL CNN+++VDLGVM P E I++ A E AD IGLSGLITPSLDEMV VAKEM R
Sbjct: 765 IVGVVLQCNNYEIVDLGVMVPAEKILRTAREVNADLIGLSGLITPSLDEMVNVAKEMERQ 824
Query: 2521 GLNIPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLN 2700
G IPLLIGGATTSK HTAVKI Y P V+ +AS++V V ++L + RD F+
Sbjct: 825 GFTIPLLIGGATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTR 884
Query: 2701 EDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIP 2880
++YE VR +H L R+ DW+++T +G +E + + L
Sbjct: 885 KEYETVRIQHARKKPRTPPVTLEAARDNDLAFDWERYTPPVAHRLGVQEVE-ASIETLRN 943
Query: 2881 YIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAV 3060
YIDW PFF W L GK YP+I +D VG EA+++F DA L KL EK+L V
Sbjct: 944 YIDWTPFFMTWSLAGK-----YPRILEDEVVGVEAQRLFKDANDMLDKLSAEKLLNPRGV 998
Query: 3061 VSFLPAASEGDDMHVYDPET-GNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDD 3237
V PA GDD+ +Y ET + L + LRQQ+ + ++CL+DF+ P +G D
Sbjct: 999 VGLFPANRVGDDIEIYRDETRTHVLTVSHHLRQQT-EKVGFANYCLADFVAPKLSG-KAD 1056
Query: 3238 YLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYST 3417
Y+G FA T GL + E HDDY IMVKA+ADRLAEA+AEYLH+ VR WGY+
Sbjct: 1057 YIGAFAVTGGLKEDALADAFEAQHDDYNKIMVKAIADRLAEAFAEYLHERVRKVYWGYAP 1116
Query: 3418 NEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKN-GIGLTEHLAMLPAAS 3594
NE L+ +L+ YQGIRPA GYP+ P+HTEK T+W+LL+ EK+ G+ LTE AM P AS
Sbjct: 1117 NESLSNDELIRENYQGIRPAPGYPACPEHTEKGTIWQLLDVEKHTGMKLTESFAMWPGAS 1176
Query: 3595 VSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGYDTD 3747
VSG YF++P+S+YFAV +I +DQV DYA RK + E+VERWL+P LGYD D
Sbjct: 1177 VSGWYFSHPESKYFAVAQIQRDQVTDYAFRKGMSVEDVERWLAPNLGYDAD 1227
>gi|16131845|ref|NP_418443.1| B12-dependent
homocysteine-N5-methyltetrahydrofolate transmethylase,
repressor of metE and metF; B12-dependent
homocysteine-N5-methyltetrahydrofolate transmethylase
[Escherichia coli K12]
gi|34395941|sp|P13009|METH_ECOLI Methionine synthase
(5-methyltetrahydrofolate--homocysteine
methyltransferase) (Methionine synthase, vitamin-B12
dependent isozyme) (MS)
gi|7427872|pir||XYECMH 5-methyltetrahydrofolate-homocysteine
S-methyltransferase (EC 2.1.1.13) - Escherichia coli
(strain K-12)
gi|1790450|gb|AAC76989.1| B12-dependent
homocysteine-N5-methyltetrahydrofolate transmethylase,
repressor of metE and metF; B12-dependent
homocysteine-N5-methyltetrahydrofolate transmethylase
[Escherichia coli K12]
Length = 1227
Score = 1244 bits (3220), Expect = 0.0
Identities = 660/1251 (52%), Positives = 848/1251 (67%), Gaps = 5/1251 (0%)
Frame = +1
Query: 10 SSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRP 189
SS E+L ERI+++DG MGTMIQ + E DFRGE D LKGNNDLL +++P
Sbjct: 2 SSKVEQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSKP 61
Query: 190 DIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAA 369
++I IH Y EAGAD +ETNTF+ TTIA ADY+ E L EIN+ +A +AR D+ A
Sbjct: 62 EVIAAIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTAR 121
Query: 370 TGRR-RYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVE 546
T + RYV G +GPTNRT SISP V P FRN+TF LV AY + ++L++GG D++L+E
Sbjct: 122 TPEKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDGLVAAYRESTKALVEGGADLILIE 181
Query: 547 TVFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKP 726
TVFD+ NAKAA+FA++T FE GV E+P+ +SGTI D SGRTLSGQT EAF S + +
Sbjct: 182 TVFDTLNAKAAVFAVKTEFEALGV-ELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEA 240
Query: 727 MAVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFAR 906
+ GLNCALG ++RQ+V +S+ ++ ++ +PNAGLPNA G YD + MA +RE+A+
Sbjct: 241 LTFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAQ 300
Query: 907 DGLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVN 1086
G +NI+GGCCGTTP HI AM +AV+G+ PR P+ P A + LSGLEP +G ++ FVN
Sbjct: 301 AGFLNIVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACR--LSGLEPLNIGEDSLFVN 358
Query: 1087 IGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLR 1266
+GER NV GS +F LIK E Y A+DVAR QV++GAQI+D+NMD+G+LD AM +FL
Sbjct: 359 VGERTNVTGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLN 418
Query: 1267 LISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGA 1446
LI+ EPD+A++P+ IDSS +DVI GL+ QGK +VNSIS+KEG + F A++++RYGA
Sbjct: 419 LIAGEPDIARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGA 478
Query: 1447 AVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNY 1626
AVVVMAFDEQGQA K EIC R+Y+ILTEEVGF P DIIFD NI +ATG+EEH+NY
Sbjct: 479 AVVVMAFDEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNY 538
Query: 1627 GMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVN 1806
FI A I+ LP A +SGGVSN+SFSFRG + +REA+H+VFL+YAI+ GMDMGIVN
Sbjct: 539 AQDFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVN 598
Query: 1807 AGALPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEM--XXXXXXXXXXXXEWRSLT 1980
AG L +Y+D+ NR + TE+LL A++ EWRS
Sbjct: 599 AGQLAIYDDLPAELRDAVEDVILNRRDDGTERLLELAEKYRGSKTDDTANAQQAEWRSWE 658
Query: 1981 VEERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFL 2160
V +RL+++LVKG+ +F+ DTEEARQ RP+ VIE PLMDGM VVG+LFG GKMFL
Sbjct: 659 VNKRLEYSLVKGITEFIEQDTEEARQQAT---RPIEVIEGPLMDGMNVVGDLFGEGKMFL 715
Query: 2161 PQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKN 2340
PQV+KSARVMK+AVA+L PF+E ++++ G +VIATVKGDVHDIGKN
Sbjct: 716 PQVVKSARVMKQAVAYLEPFIE-----------ASKEQGKTNGKMVIATVKGDVHDIGKN 764
Query: 2341 IVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRV 2520
IV VVL CNN+++VDLGVM P E I++ A E AD IGLSGLITPSLDEMV VAKEM R
Sbjct: 765 IVGVVLQCNNYEIVDLGVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQ 824
Query: 2521 GLNIPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLN 2700
G IPLLIGGATTSK HTAVKI Y P V+ +AS++V V ++L + RD F+
Sbjct: 825 GFTIPLLIGGATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTR 884
Query: 2701 EDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIP 2880
++YE VR +H L R+ F DW +T +G +E + + L
Sbjct: 885 KEYETVRIQHGRKKPRTPPVTLEAARDNDFAFDWQAYTPPVAHRLGVQEVE-ASIETLRN 943
Query: 2881 YIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAV 3060
YIDW PFF W L GK YP+I +D VG EA+++F DA L KL EK L V
Sbjct: 944 YIDWTPFFMTWSLAGK-----YPRILEDEVVGVEAQRLFKDANDMLDKLSAEKTLNPRGV 998
Query: 3061 VSFLPAASEGDDMHVYDPET-GNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDD 3237
V PA GDD+ +Y ET + ++ + LRQQ+ + ++CL+DF+ P +G D
Sbjct: 999 VGLFPANRVGDDIEIYRDETRTHVINVSHHLRQQT-EKTGFANYCLADFVAPKLSG-KAD 1056
Query: 3238 YLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYST 3417
Y+G FA T GL + E HDDY IMVKALADRLAEA+AEYLH+ VR WGY+
Sbjct: 1057 YIGAFAVTGGLEEDALADAFEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAP 1116
Query: 3418 NEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKN-GIGLTEHLAMLPAAS 3594
NE+L+ +L+ YQGIRPA GYP+ P+HTEK T+W+LLE EK+ G+ LTE AM P AS
Sbjct: 1117 NENLSNEELIRENYQGIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGAS 1176
Query: 3595 VSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGYDTD 3747
VSG YF++P S+Y+AV +I +DQV DYA RK + EVERWL+P LGYD D
Sbjct: 1177 VSGWYFSHPDSKYYAVAQIQRDQVEDYARRKGMSVTEVERWLAPNLGYDAD 1227
>gi|409794|gb|AAC43113.1| B12-dependent
homocysteine-N5-methyltetrahydrofolate transmethylase
Length = 1227
Score = 1244 bits (3220), Expect = 0.0
Identities = 660/1251 (52%), Positives = 848/1251 (67%), Gaps = 5/1251 (0%)
Frame = +1
Query: 10 SSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRP 189
SS E+L ERI+++DG MGTMIQ + E DFRGE D LKGNNDLL +++P
Sbjct: 2 SSKVEQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSKP 61
Query: 190 DIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAA 369
++I IH Y EAGAD +ETNTF+ TTIA ADY+ E L EIN+ +A +AR D+ A
Sbjct: 62 EVIAAIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTAR 121
Query: 370 TGRR-RYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVE 546
T + RYV G +GPTNRT SISP V P FRN+TF LV AY + ++L++GG D++L+E
Sbjct: 122 TPEKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDGLVAAYRESTKALVEGGADLILIE 181
Query: 547 TVFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKP 726
TVFD+ NAKAA+FA++T FE GV E+P+ +SGTI D SGRTLSGQT EAF S + +
Sbjct: 182 TVFDTLNAKAAVFAVKTEFEALGV-ELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEA 240
Query: 727 MAVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFAR 906
+ GLNCALG ++RQ+V +S+ ++ ++ +PNAGLPNA G YD + MA +RE+A+
Sbjct: 241 LTFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAQ 300
Query: 907 DGLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVN 1086
G +NI+GGCCGTTP HI AM +AV+G+ PR P+ P A + LSGLEP +G ++ FVN
Sbjct: 301 AGFLNIVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACR--LSGLEPLNIGEDSLFVN 358
Query: 1087 IGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLR 1266
+GER NV GS +F LIK E Y A+DVAR QV++GAQI+D+NMD+G+LD AM +FL
Sbjct: 359 VGERTNVTGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLN 418
Query: 1267 LISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGA 1446
LI+ EPD+A++P+ IDSS +DVI GL+ QGK +VNSIS+KEG + F A++++RYGA
Sbjct: 419 LIAGEPDIARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGA 478
Query: 1447 AVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNY 1626
AVVVMAFDEQGQA K EIC R+Y+ILTEEVGF P DIIFD NI +ATG+EEH+NY
Sbjct: 479 AVVVMAFDEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNY 538
Query: 1627 GMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVN 1806
FI A I+ LP A +SGGVSN+SFSFRG + +REA+H+VFL+YAI+ GMDMGIVN
Sbjct: 539 AQDFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVN 598
Query: 1807 AGALPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEM--XXXXXXXXXXXXEWRSLT 1980
AG L +Y+D+ NR + TE+LL A++ EWRS
Sbjct: 599 AGQLAIYDDLPAELRDAVEDVILNRRDDGTERLLELAEKYRGSKTDDTANAQQAEWRSWE 658
Query: 1981 VEERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFL 2160
V +RL+++LVKG+ +F+ DTEEARQ RP+ VIE PLMDGM VVG+LFG GKMFL
Sbjct: 659 VNKRLEYSLVKGITEFIEQDTEEARQQXT---RPIEVIEGPLMDGMNVVGDLFGEGKMFL 715
Query: 2161 PQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKN 2340
PQV+KSARVMK+AVA+L PF+E ++++ G +VIATVKGDVHDIGKN
Sbjct: 716 PQVVKSARVMKQAVAYLEPFIE-----------ASKEQGKTNGKMVIATVKGDVHDIGKN 764
Query: 2341 IVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRV 2520
IV VVL CNN+++VDLGVM P E I++ A E AD IGLSGLITPSLDEMV VAKEM R
Sbjct: 765 IVGVVLQCNNYEIVDLGVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQ 824
Query: 2521 GLNIPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLN 2700
G IPLLIGGATTSK HTAVKI Y P V+ +AS++V V ++L + RD F+
Sbjct: 825 GFTIPLLIGGATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTR 884
Query: 2701 EDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIP 2880
++YE VR +H L R+ F DW +T +G +E + + L
Sbjct: 885 KEYETVRIQHGRKKPRTPPVTLEAARDNDFAFDWQAYTPPVAHRLGVQEVE-ASIETLRN 943
Query: 2881 YIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAV 3060
YIDW PFF W L GK YP+I +D VG EA+++F DA L KL EK L V
Sbjct: 944 YIDWTPFFMTWSLAGK-----YPRILEDEVVGVEAQRLFKDANDMLDKLSAEKTLNPRGV 998
Query: 3061 VSFLPAASEGDDMHVYDPET-GNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDD 3237
V PA GDD+ +Y ET + ++ + LRQQ+ + ++CL+DF+ P +G D
Sbjct: 999 VGLFPANRVGDDIEIYRDETRTHVINVSHHLRQQT-EKTGFANYCLADFVAPKLSG-KAD 1056
Query: 3238 YLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYST 3417
Y+G FA T GL + E HDDY IMVKALADRLAEA+AEYLH+ VR WGY+
Sbjct: 1057 YIGAFAVTGGLEEDALADAFEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAP 1116
Query: 3418 NEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKN-GIGLTEHLAMLPAAS 3594
NE+L+ +L+ YQGIRPA GYP+ P+HTEK T+W+LLE EK+ G+ LTE AM P AS
Sbjct: 1117 NENLSNEELIRENYQGIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGAS 1176
Query: 3595 VSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGYDTD 3747
VSG YF++P S+Y+AV +I +DQV DYA RK + EVERWL+P LGYD D
Sbjct: 1177 VSGWYFSHPDSKYYAVAQIQRDQVEDYARRKGMSVTEVERWLAPNLGYDAD 1227
>gi|15804605|ref|NP_290646.1| B12-dependent
homocysteine-N5-methyltetrahydrofolate transmethylase,
repressor of metE and metF [Escherichia coli O157:H7
EDL933]
gi|15834191|ref|NP_312964.1| B12-dependent
homocysteine-N5-methyltetrahydrofolate transmethylase
[Escherichia coli O157:H7]
gi|25285949|pir||A98246 hypothetical protein ECs4937 [imported] -
Escherichia coli (strain O157:H7, substrain RIMD
0509952)
gi|25285952|pir||G86093 hypothetical protein metH [imported] -
Escherichia coli (strain O157:H7, substrain EDL933)
gi|12518952|gb|AAG59211.1| B12-dependent
homocysteine-N5-methyltetrahydrofolate transmethylase,
repressor of metE and metF [Escherichia coli O157:H7
EDL933]
gi|13364413|dbj|BAB38360.1| B12-dependent
homocysteine-N5-methyltetrahydrofolate transmethylase
[Escherichia coli O157:H7]
Length = 1227
Score = 1244 bits (3218), Expect = 0.0
Identities = 658/1251 (52%), Positives = 849/1251 (67%), Gaps = 5/1251 (0%)
Frame = +1
Query: 10 SSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRP 189
SS E+L ERI+++DG MGTMIQ + E DFRGE D LKGNNDLL +++P
Sbjct: 2 SSKVEQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSKP 61
Query: 190 DIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAA 369
++I IH Y EAGAD +ETNTF+ TTIA ADY+ E L EIN+ +A +AR D+ A
Sbjct: 62 EVIAAIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTAR 121
Query: 370 TGRR-RYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVE 546
T + RYV G +GPTNRT SISP V P FRN+TF +LV AY + ++L++GG D++L+E
Sbjct: 122 TPEKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGADLILIE 181
Query: 547 TVFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKP 726
TVFD+ NAKAA+FA++T FE GV E+P+ +SGTI D SGRTLSGQT EAF S + +
Sbjct: 182 TVFDTLNAKAAVFAVKTEFEALGV-ELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEA 240
Query: 727 MAVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFAR 906
+ GLNCALG ++RQ+V +S+ ++ ++ +PNAGLPNA G YD + MA +RE+A+
Sbjct: 241 LTFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAQ 300
Query: 907 DGLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVN 1086
G +NI+GGCCGTTP HI AM +AV+G+ PR P+ P A + LSGLEP +G ++ FVN
Sbjct: 301 AGFLNIVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACR--LSGLEPLNIGDDSLFVN 358
Query: 1087 IGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLR 1266
+GER NV GS +F LIK E Y A+DVAR QV++GAQI+D+NMD+G+LD AM +FL
Sbjct: 359 VGERTNVTGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLN 418
Query: 1267 LISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGA 1446
LI+ EPD+A++P+ IDSS ++VI GL+ QGK +VNSIS+KEG + F A++++RYGA
Sbjct: 419 LIAGEPDIARVPIMIDSSKWEVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGA 478
Query: 1447 AVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNY 1626
AVVVMAFDEQGQA K EIC R+Y+ILTEEVGF P DIIFD NI +ATG+EEH+NY
Sbjct: 479 AVVVMAFDEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNY 538
Query: 1627 GMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVN 1806
FI A I+ LP A +SGGVSN+SFSFRG + +REA+H+VFL+YAI+ GMDMGIVN
Sbjct: 539 AQDFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVN 598
Query: 1807 AGALPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEM--XXXXXXXXXXXXEWRSLT 1980
AG L +Y+D+ NR + TE+LL A++ EWRS
Sbjct: 599 AGQLAIYDDLPAELRDAVEDVILNRRDDGTERLLELAEKYRGSKTDDTANAQQAEWRSWE 658
Query: 1981 VEERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFL 2160
V +RL+++LVKG+ +F+ DTEEARQ RP+ VIE PLMDGM VVG+LFG GKMFL
Sbjct: 659 VNKRLEYSLVKGITEFIEQDTEEARQQAT---RPIEVIEGPLMDGMNVVGDLFGEGKMFL 715
Query: 2161 PQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKN 2340
PQV+KSARVMK+AVA+L PF+E ++++ G +VIATVKGDVHDIGKN
Sbjct: 716 PQVVKSARVMKQAVAYLEPFIE-----------ASKEQGKTNGKMVIATVKGDVHDIGKN 764
Query: 2341 IVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRV 2520
IV VVL CNN+++VDLGVM P E I++ A E AD IGLSGLITPSLDEMV VAKEM R
Sbjct: 765 IVGVVLQCNNYEIVDLGVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQ 824
Query: 2521 GLNIPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLN 2700
G IPLLIGGATTSK HTAVKI Y P V+ +AS++V V ++L + RD F+
Sbjct: 825 GFTIPLLIGGATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTR 884
Query: 2701 EDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIP 2880
++YE VR +H L R+ F DW +T +G +E + + L
Sbjct: 885 KEYETVRIQHGRKKPRTPPVTLEAARDNDFAFDWQAYTPPVAHRLGVQEVE-ASIETLRN 943
Query: 2881 YIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAV 3060
YIDW PFF W L GK YP+I +D VG EA+++F DA L KL EK L V
Sbjct: 944 YIDWTPFFMTWSLAGK-----YPRILEDEVVGVEAQRLFKDANDMLDKLSAEKTLNPRGV 998
Query: 3061 VSFLPAASEGDDMHVYDPET-GNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDD 3237
V PA GDD+ +Y ET + ++ + LRQQ+ + ++CL+DF+ P +G D
Sbjct: 999 VGLFPANRVGDDIEIYRDETRTHVINVSHHLRQQT-EKTGFANYCLADFVAPKLSG-KAD 1056
Query: 3238 YLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYST 3417
Y+G FA T GL + E HDDY IMVKALADRLAEA+AEYLH+ VR WGY+
Sbjct: 1057 YIGAFAVTGGLEEDALADAFEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAP 1116
Query: 3418 NEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKN-GIGLTEHLAMLPAAS 3594
NE+L+ +L+ YQGIRPA GYP+ P+HTEK T+W+LLE EK+ G+ LTE AM P AS
Sbjct: 1117 NENLSNEELIRENYQGIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGAS 1176
Query: 3595 VSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGYDTD 3747
VSG YF++P S+Y+AV +I +DQV DYA RK + +VERWL+P LGYD D
Sbjct: 1177 VSGWYFSHPDSKYYAVAQIQRDQVEDYARRKGMSVSDVERWLAPNLGYDAD 1227
>gi|15640417|ref|NP_230044.1| 5-methyltetrahydrofolate--homocysteine
methyltransferase [Vibrio cholerae O1 biovar eltor str.
N16961]
gi|11256614|pir||E82328 5-methyltetrahydrofolate-homocysteine
methyltransferase VC0390 [imported] - Vibrio cholerae
(strain N16961 serogroup O1)
gi|9654810|gb|AAF93563.1| 5-methyltetrahydrofolate--homocysteine
methyltransferase [Vibrio cholerae O1 biovar eltor str.
N16961]
Length = 1226
Score = 1243 bits (3216), Expect = 0.0
Identities = 647/1242 (52%), Positives = 852/1242 (68%), Gaps = 5/1242 (0%)
Frame = +1
Query: 22 EELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRPDIIY 201
++L + K+RI++IDG MGTMIQ ++EED+RG D LKGNNDLL +T+P II
Sbjct: 7 QQLEQQLKQRILLIDGGMGTMIQSYKLQEEDYRGARFVDWHCDLKGNNDLLVLTQPQIIK 66
Query: 202 KIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAAT-GR 378
+IH YLEAGAD +ETNTF+ TTIA ADY + L EIN+ +A +AR D+ A R
Sbjct: 67 EIHSAYLEAGADILETNTFNSTTIAMADYDMQSLSAEINFAAAKLAREVADEWTAKDPSR 126
Query: 379 RRYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVETVFD 558
RYV G +GPTNRT SISP V P FRNVTF LV+AY + R+LI+GG D++L+ET+FD
Sbjct: 127 PRYVAGVLGPTNRTCSISPDVNDPGFRNVTFDGLVEAYSESTRALIKGGSDLILIETIFD 186
Query: 559 SANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKPMAVG 738
+ NAKA FA+ ++FE+ G+ +PV +SGTI D SGRTLSGQT EAF + + +P++ G
Sbjct: 187 TLNAKACAFAVDSVFEELGI-SLPVMISGTITDASGRTLSGQTTEAFYNALRHVRPISFG 245
Query: 739 LNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFARDGLV 918
LNCALG ++RQ+V+ +S+ S+ ++ +PNAGLPNA G YD + EEMA+ + E+A+ G +
Sbjct: 246 LNCALGPDELRQYVEELSRISECYVSAHPNAGLPNAFGEYDLSAEEMAEHIAEWAQAGFL 305
Query: 919 NIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVNIGER 1098
N++GGCCGTTP+HI A+ KAV+G+ PR P + LSGLEP +GPET FVN+GER
Sbjct: 306 NLVGGCCGTTPEHIAAIAKAVEGVKPRALPD--LKVECRLSGLEPLNIGPETLFVNVGER 363
Query: 1099 CNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLRLISS 1278
NV GS RF LIK E YD A+DVAR QV++GAQI+D+NMD+G+LD M +FL L +S
Sbjct: 364 TNVTGSARFKRLIKEEQYDEALDVAREQVENGAQIIDINMDEGMLDAEACMVRFLNLCAS 423
Query: 1279 EPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGAAVVV 1458
EP+++K+PV +DSS ++VI AGL+ QGK +VNSISLKEG+EKF +A++++RYGAAV+V
Sbjct: 424 EPEISKVPVMVDSSKWEVIEAGLKCIQGKGIVNSISLKEGKEKFIAQAKLVRRYGAAVIV 483
Query: 1459 MAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNYGMYF 1638
MAFDE GQA + K EIC R+Y IL +EVGF P DIIFD NI +ATG++EH+NY + F
Sbjct: 484 MAFDEVGQADTRERKLEICRRAYHILVDEVGFPPEDIIFDPNIFAVATGIDEHNNYALDF 543
Query: 1639 IEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVNAGAL 1818
I A I+ LP A +SGGVSN+SFSFRG +REA+H+VFL++ K GMDMGIVNAG L
Sbjct: 544 INAVADIKRELPHAMISGGVSNVSFSFRGNNYVREAIHAVFLYHCFKHGMDMGIVNAGQL 603
Query: 1819 PVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQ--EMXXXXXXXXXXXXEWRSLTVEER 1992
+Y+++ NR + TE+LL A+ EWR+ V +R
Sbjct: 604 EIYDNVPLKLREAVEDVILNRRSDGTERLLEIAEAYRENSVGKEEDASALEWRAWPVAKR 663
Query: 1993 LKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFLPQVI 2172
L+ ALVKG+ +F+V DTEEARQ +K PL VIE PLMDGM VVG+LFG GKMFLPQV+
Sbjct: 664 LEHALVKGITEFIVQDTEEARQQASK---PLEVIEGPLMDGMNVVGDLFGEGKMFLPQVV 720
Query: 2173 KSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKNIVSV 2352
KSARVMK+AVA+L PF+ ++ S G +++ATVKGDVHDIGKNIV V
Sbjct: 721 KSARVMKQAVAYLEPFINAQKSG-----------STSNGKILLATVKGDVHDIGKNIVGV 769
Query: 2353 VLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRVGLNI 2532
VL CNNF+++DLGVM PCE I+K A E+ D IGLSGLITPSLDEMV+VAKEM R G +
Sbjct: 770 VLQCNNFEIIDLGVMVPCEQILKVAREQNVDIIGLSGLITPSLDEMVHVAKEMERQGFEL 829
Query: 2533 PLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLNEDYE 2712
PLLIGGATTSK HTAVKI Y PVV+ +AS++V VC+SL R F++ L+ DYE
Sbjct: 830 PLLIGGATTSKAHTAVKIEQNYHAPVVYVNNASRAVGVCTSLLSDEQRPGFIERLDLDYE 889
Query: 2713 DVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIPYIDW 2892
R +H R L + R K +DW +T P+ G ++N L L PYIDW
Sbjct: 890 RTRDQHARKTPKSRPVTLEQARANKAALDWANYTPPAPAKPGVHVFENIALATLRPYIDW 949
Query: 2893 KPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAVVSFL 3072
PFF W L GK YP I + +VG EAK++F DA L K+ E +L A+ + +
Sbjct: 950 TPFFMTWSLMGK-----YPAILEHEEVGEEAKRLFHDANALLDKVEREGLLKASGMCALF 1004
Query: 3073 PAASEGDDMHVYDPETGNKL-DTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDDYLGL 3249
PAAS GDD+ VY E+ ++ Y LRQQ+ + ++CLSD++ P ++G D++G
Sbjct: 1005 PAASVGDDIEVYSDESRTQVAHVLYNLRQQTEKPKG-ANYCLSDYVAPKESG-KRDWIGA 1062
Query: 3250 FACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYSTNEDL 3429
FA T G+G + DDY +IM++A+ADRLAEA+AEYLH++VR +WGY+++E+L
Sbjct: 1063 FAVTGGIGERALADAYKAQGDDYNAIMIQAVADRLAEAFAEYLHEKVRKEIWGYASDENL 1122
Query: 3430 TESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKN-GIGLTEHLAMLPAASVSGL 3606
+ DL+ +YQGIRPA GYP+ P+HTEK TLW++L E+ G+ LT AM P ASVSG
Sbjct: 1123 SNDDLIRERYQGIRPAPGYPACPEHTEKATLWQMLNVEETIGMSLTTSYAMWPGASVSGW 1182
Query: 3607 YFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPIL 3732
YF++P S YFAV +I DQ+ YA RK EE E+WL+P L
Sbjct: 1183 YFSHPDSRYFAVAQIQPDQLHSYAERKGWRLEEAEKWLAPNL 1224
>gi|48733343|ref|ZP_00267086.1| COG1410: Methionine synthase I,
cobalamin-binding domain [Pseudomonas fluorescens PfO-1]
Length = 1236
Score = 1242 bits (3214), Expect = 0.0
Identities = 654/1255 (52%), Positives = 850/1255 (67%), Gaps = 10/1255 (0%)
Frame = +1
Query: 7 RSSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITR 186
RS + L + KERI+I+DG MGTMIQ +EE+D+RG+ D +KGNNDLL +TR
Sbjct: 4 RSVRLQALKQALKERILILDGGMGTMIQSYKLEEQDYRGKRFADWPSDVKGNNDLLVLTR 63
Query: 187 PDIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGA 366
PD+I I K YL+AGAD +ETNTF+ T I+ ADY E LV+E+N + A +AR+ D
Sbjct: 64 PDVIGGIEKAYLDAGADILETNTFNATQISMADYGMEELVYELNVEGARLARKVADAKTL 123
Query: 367 AT-GRRRYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLV 543
T + R+V G +GPT+RT S+SP V P +RNVTF ELV+ Y + + LI+GG D++L+
Sbjct: 124 ETPDKPRFVAGVLGPTSRTCSLSPDVNNPGYRNVTFDELVENYTEATKGLIEGGADLILI 183
Query: 544 ETVFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGK 723
ET+FD+ NAKAA+FA++ +FE+ G E+P+ +SGTI D SGRTLSGQT EAF S K
Sbjct: 184 ETIFDTLNAKAAIFAVQGVFEELGF-ELPIMISGTITDASGRTLSGQTTEAFWNSVAHAK 242
Query: 724 PMAVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFA 903
P++VGLNCALGA+++R +++ +S + + + +PNAGLPN G YDE P + A V+ EFA
Sbjct: 243 PISVGLNCALGARELRPYLEELSDKASTHVSAHPNAGLPNEFGEYDELPVDTAKVIEEFA 302
Query: 904 RDGLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFV 1083
+ G +NI+GGCCGTTP HI A+ KAV G PR P P A + LSGLEP + + FV
Sbjct: 303 QSGFLNIVGGCCGTTPGHIEAIAKAVAGYAPRQIPDIPKACR--LSGLEPFTIDRSSLFV 360
Query: 1084 NIGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFL 1263
N+GER N+ GS +F LI+ +NY A++VA QV++GAQ++D+NMD+G+LD AM FL
Sbjct: 361 NVGERTNITGSAKFARLIREDNYTEALEVALQQVEAGAQVIDINMDEGMLDSKKAMVTFL 420
Query: 1264 RLISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYG 1443
LI+ EPD++++P+ IDSS +DVI AGL+ QGK +VNSIS+KEG E+F A++ KRYG
Sbjct: 421 NLIAGEPDISRVPIMIDSSKWDVIEAGLKCIQGKGIVNSISMKEGVEQFIHHAKLCKRYG 480
Query: 1444 AAVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSN 1623
AAVVVMAFDE GQA K EIC+RSY IL EVGF P DIIFD NI +ATG+EEH+N
Sbjct: 481 AAVVVMAFDEAGQADTEARKKEICKRSYDILVNEVGFPPEDIIFDPNIFAVATGIEEHNN 540
Query: 1624 YGMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIV 1803
Y + FI A IR+ LP A SGGVSN+SFSFRG +REA+HSVFL YAI+AG+ MGIV
Sbjct: 541 YAVDFINACAYIRDELPYALSSGGVSNVSFSFRGNNPVREAIHSVFLLYAIRAGLTMGIV 600
Query: 1804 NAGALPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEMXXXXXXXXXXXXEWRSLTV 1983
NAG L +Y+ I + NR PE T+ LL A + EWR V
Sbjct: 601 NAGQLEIYDQIPQELRDAVEDVILNRTPEGTDALLAIADKYKGDGSVKEAETEEWRGWDV 660
Query: 1984 EERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFLP 2163
+RL+ ALVKG+ +V DTEE+RQ+ + RP+ VIE PLM GM +VG+LFGAGKMFLP
Sbjct: 661 NKRLEHALVKGITTHIVEDTEESRQS---FARPIEVIEGPLMSGMNIVGDLFGAGKMFLP 717
Query: 2164 QVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKNI 2343
QV+KSARVMK+AVAHL+PF+E+E+ D+ +G +++ATVKGDVHDIGKNI
Sbjct: 718 QVVKSARVMKQAVAHLIPFIELEK----------GDKPEAKGKILMATVKGDVHDIGKNI 767
Query: 2344 VSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRVG 2523
V VVLGCN + +VDLGVM P E I++ A E+K D IGLSGLITPSLDEMV+VA+EM R
Sbjct: 768 VGVVLGCNGYDIVDLGVMVPAEKILQVAKEQKCDIIGLSGLITPSLDEMVHVAREMQRQD 827
Query: 2524 LNIPLLIGGATTSKTHTAVKISPRYPH-PVVHCLDASKSVVVCSSLSDMSVRDAFLQDLN 2700
++PL+IGGATTSK HTAVKI P+Y + VV+ DAS++V V + L ++ F+Q
Sbjct: 828 FHLPLMIGGATTSKAHTAVKIEPKYSNDAVVYVTDASRAVGVATQLLSKELKAGFVQKTR 887
Query: 2701 EDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIP 2880
E+Y DVR+ KK + DW +T VKP+F G R N DLN L
Sbjct: 888 EEYIDVRERTANRSARTERLSYAAAIAKKPQFDWATYTPVKPTFTGTRVLDNIDLNVLAE 947
Query: 2881 YIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAV 3060
YIDW PFF W L GK +P+I +D VG A ++ DA+ L KLIDEK++ A AV
Sbjct: 948 YIDWTPFFISWDLAGK-----FPRILEDEVVGEAATALYKDAREMLTKLIDEKLISARAV 1002
Query: 3061 VSFLPAAS-EGDDMHVYDPETGNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDD 3237
F PA DD+ +Y + G + + LRQQ + +P+F L+DF+ P K+ D
Sbjct: 1003 FGFWPANQVHDDDIELYG-DDGKPMARLHHLRQQIIKTDGKPNFSLADFVAP-KDSEVTD 1060
Query: 3238 YLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYST 3417
Y+G F TAG+GAEE K + DDY SIMVKALADRLAEA AE+LH++VR WGY+
Sbjct: 1061 YVGGFITTAGIGAEEVAKAYQDAGDDYNSIMVKALADRLAEACAEWLHQQVRKEHWGYAK 1120
Query: 3418 NEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAE-------KNGIGLTEHLA 3576
+E L L+ +Y GIRPA GYP+ PDHTEK TL+ LL+ E ++G+ LTEH A
Sbjct: 1121 DEALDNEALIKEQYSGIRPAPGYPACPDHTEKATLFALLDPEAQEMRAGRSGVFLTEHYA 1180
Query: 3577 MLPAASVSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGYD 3741
M PAA+VSG YFA+PQ++YFAVGK+D+DQV Y +RK ERWL+P LGYD
Sbjct: 1181 MFPAAAVSGWYFAHPQAQYFAVGKVDKDQVQSYTSRKGQELSLTERWLAPNLGYD 1235
>gi|26250788|ref|NP_756828.1| 5-methyltetrahydrofolate--homocysteine
methyltransferase [Escherichia coli CFT073]
gi|26111219|gb|AAN83402.1| 5-methyltetrahydrofolate--homocysteine
methyltransferase [Escherichia coli CFT073]
Length = 1227
Score = 1242 bits (3213), Expect = 0.0
Identities = 658/1251 (52%), Positives = 848/1251 (67%), Gaps = 5/1251 (0%)
Frame = +1
Query: 10 SSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRP 189
SS E+L ERI+++DG MGTMIQ + E DFRGE D LKGNNDLL +++P
Sbjct: 2 SSKVEQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSKP 61
Query: 190 DIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAA 369
++I IH Y EAGAD +ETNTF+ TTIA ADY+ E L EIN+ +A +AR D+ A
Sbjct: 62 EVIAAIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTAR 121
Query: 370 TGRR-RYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVE 546
T + RYV G +GPTNRT SISP V P FRN+TF +LV AY + ++L++GG D++L+E
Sbjct: 122 TPEKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGADLILIE 181
Query: 547 TVFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKP 726
TVFD+ NAKAA+FA++T FE GV E+P+ +SGTI D SGRTLSGQT EAF S + +
Sbjct: 182 TVFDTLNAKAAVFAVKTEFEALGV-ELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEA 240
Query: 727 MAVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFAR 906
+ GLNCALG ++RQ+V +S+ ++ ++ +PNAGLPNA G YD + MA +RE+A
Sbjct: 241 LTFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAE 300
Query: 907 DGLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVN 1086
G +NI+GGCCGTTP HI AM +AV+G+ PR P+ P A + LSGLEP +G ++ FVN
Sbjct: 301 AGFLNIVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACR--LSGLEPLNIGEDSLFVN 358
Query: 1087 IGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLR 1266
+GER NV GS +F LIK E Y A+DVAR QV++GAQI+D+NMD+G+LD AM +FL
Sbjct: 359 VGERTNVTGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLN 418
Query: 1267 LISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGA 1446
LI+ EPD+A++P+ IDSS +DVI GL+ QGK +VNSIS+KEG + F A++++RYGA
Sbjct: 419 LIAGEPDIARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGA 478
Query: 1447 AVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNY 1626
AVVVMAFDEQGQA K EIC R+Y+ILTEEVGF DIIFD NI +ATG+EEH+NY
Sbjct: 479 AVVVMAFDEQGQADTRARKIEICRRAYKILTEEVGFPAEDIIFDPNIFAVATGIEEHNNY 538
Query: 1627 GMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVN 1806
FI A I+ LP A +SGGVSN+SFSFRG + +REA+H+VFL+YAI+ GMDMGIVN
Sbjct: 539 AQDFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVN 598
Query: 1807 AGALPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEM--XXXXXXXXXXXXEWRSLT 1980
AG L +Y+D+ NR + TE+LL A++ EWRS
Sbjct: 599 AGQLAIYDDLPTELRDAVEDVILNRRDDGTERLLELAEKYRGSKTDDTANTQQAEWRSWE 658
Query: 1981 VEERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFL 2160
V +RL+++LVKG+ +F+ DTEEARQ RP+ VIE PLMDGM VVG+LFG GKMFL
Sbjct: 659 VNKRLEYSLVKGITEFIEQDTEEARQQAT---RPIEVIEGPLMDGMNVVGDLFGEGKMFL 715
Query: 2161 PQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKN 2340
PQV+KSARVMK+AVA+L PF+E ++++ G +VIATVKGDVHDIGKN
Sbjct: 716 PQVVKSARVMKQAVAYLEPFIE-----------ASKEQGKTNGKMVIATVKGDVHDIGKN 764
Query: 2341 IVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRV 2520
IV VVL CNN+++VDLGVM P E I++ A E AD IGLSGLITPSLDEMV VAKEM R
Sbjct: 765 IVGVVLQCNNYEIVDLGVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQ 824
Query: 2521 GLNIPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLN 2700
G IPLLIGGATTSK HTAVKI Y P V+ +AS++V V ++L + RD F+
Sbjct: 825 GFTIPLLIGGATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTR 884
Query: 2701 EDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIP 2880
++YE VR +H L R+ F DW +T +G +E + + L
Sbjct: 885 KEYETVRIQHGRKKPRTPPVTLEAARDNDFAFDWQAYTPPVAHRLGVQEVE-ASIETLRN 943
Query: 2881 YIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAV 3060
YIDW PFF W L GK YP+I +D VG EA+++F DA L KL EK+L V
Sbjct: 944 YIDWTPFFMTWSLAGK-----YPRILEDEVVGVEAQRLFKDANDMLDKLSAEKMLNPRGV 998
Query: 3061 VSFLPAASEGDDMHVYDPET-GNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDD 3237
V PA GDD+ +Y ET + ++ + LRQQ+ + ++CL+DF+ P +G D
Sbjct: 999 VGLFPANRVGDDIEIYRDETRTHVINVSHHLRQQT-EKTGFANYCLADFVAPKVSG-KAD 1056
Query: 3238 YLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYST 3417
Y+G FA T GL + E HDDY IMVKALADRLAEA+AEYLH+ VR WGY+
Sbjct: 1057 YIGAFAVTGGLEEDALADAFEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAP 1116
Query: 3418 NEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKN-GIGLTEHLAMLPAAS 3594
NE+L+ +L+ YQGIRPA GYP+ P+HTEK T+W+LLE EK+ G+ LTE AM P AS
Sbjct: 1117 NENLSNEELIRENYQGIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGAS 1176
Query: 3595 VSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGYDTD 3747
VSG YF++P S+Y+AV +I +DQV DYA RK + EVERWL+P LGYD +
Sbjct: 1177 VSGWYFSHPDSKYYAVAQIQRDQVEDYARRKGMSVTEVERWLAPNLGYDAE 1227
>gi|30064707|ref|NP_838878.1| B12-dependent
homocysteine-N5-methyltetrahydrofolate transmethylase
[Shigella flexneri 2a str. 2457T]
gi|30042967|gb|AAP18689.1| B12-dependent
homocysteine-N5-methyltetrahydrofolate transmethylase
[Shigella flexneri 2a str. 2457T]
Length = 1227
Score = 1239 bits (3207), Expect = 0.0
Identities = 657/1251 (52%), Positives = 848/1251 (67%), Gaps = 5/1251 (0%)
Frame = +1
Query: 10 SSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRP 189
SS E+L ERI+++DG MGTMIQ + E DFRGE D LKGNNDLL +++P
Sbjct: 2 SSKVEQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSKP 61
Query: 190 DIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAA 369
++I IH Y EAGAD +ETNTF+ TTIA ADY+ E L EIN+ +A +AR D+ A
Sbjct: 62 EVIAAIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTAR 121
Query: 370 TGRR-RYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVE 546
T + RYV G +GPTNRT SISP V P FRN+TF +L AY + ++L++GG D++L+E
Sbjct: 122 TPEKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLAAAYRESTKALVEGGADLILIE 181
Query: 547 TVFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKP 726
TVFD+ NAKAA+FA++T FE GV E+P+ +SGTI D SGRTLSGQT EAF S + +
Sbjct: 182 TVFDTLNAKAAVFAVKTEFEALGV-ELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEA 240
Query: 727 MAVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFAR 906
+ GLNCALG ++RQ+V +S+ ++ ++ +PNAGLPNA G YD + MA +RE+A+
Sbjct: 241 LTFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAQ 300
Query: 907 DGLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVN 1086
G +NI+GGCCGTTP HI AM +AV+G+ PR P+ P A + LSGLEP +G ++ FVN
Sbjct: 301 AGFLNIVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACR--LSGLEPLNIGDDSLFVN 358
Query: 1087 IGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLR 1266
+GER NV GS +F LIK E Y A+DVAR QV++GAQI+D+NMD+G+LD AM +FL
Sbjct: 359 VGERTNVTGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLN 418
Query: 1267 LISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGA 1446
LI+ EPD+A++P+ IDSS +DVI GL+ QGK +VNSIS+KEG + F A++++RYGA
Sbjct: 419 LIAGEPDIARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGA 478
Query: 1447 AVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNY 1626
AVVVMAFDEQGQA K EIC R+Y+ILTEEVGF P DIIFD NI +ATG+EEH+NY
Sbjct: 479 AVVVMAFDEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNY 538
Query: 1627 GMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVN 1806
FI A I+ LP A +SGGVSN+SFSFRG + +REA+H+VFL+YAI+ GMDMGIVN
Sbjct: 539 AQDFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVN 598
Query: 1807 AGALPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEM--XXXXXXXXXXXXEWRSLT 1980
AG L +Y+D+ NR + TE+LL A++ EWRS
Sbjct: 599 AGQLAIYDDLPAELRDAVEDVILNRRDDGTERLLELAEKYRGSKADDTANAQQAEWRSWD 658
Query: 1981 VEERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFL 2160
V +RL+++LVKG+ +F+ DTEEARQ RP+ VIE PLMDGM VVG+LFG GKMFL
Sbjct: 659 VNKRLEYSLVKGITEFIEQDTEEARQQAT---RPIEVIEGPLMDGMNVVGDLFGEGKMFL 715
Query: 2161 PQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKN 2340
PQV+KSARVMK+AVA+L PF+E ++++ G +VIATVKGDVHDIGKN
Sbjct: 716 PQVVKSARVMKQAVAYLEPFIE-----------ASKEQGKTNGKMVIATVKGDVHDIGKN 764
Query: 2341 IVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRV 2520
IV VVL CNN+++VDLGVM P E I++ A E AD IGLSGLITPSLDEMV VAKEM R
Sbjct: 765 IVGVVLQCNNYEIVDLGVMVPAEKILRIAKEVNADLIGLSGLITPSLDEMVNVAKEMERQ 824
Query: 2521 GLNIPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLN 2700
G IPLLIGGATTSK HTAVKI Y P V+ +AS++V V ++L + RD F+
Sbjct: 825 GFAIPLLIGGATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTC 884
Query: 2701 EDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIP 2880
++YE VR +H L R+ F DW +T +G +E + + L
Sbjct: 885 KEYETVRIQHGRKKPRTPPVTLEAARDNDFAFDWQAYTPPVAHRLGVQEVE-ASIETLRN 943
Query: 2881 YIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAV 3060
YIDW PFF W L GK YP+I +D VG EA+++F DA L KL EK L V
Sbjct: 944 YIDWTPFFMTWSLAGK-----YPRILEDEVVGVEAQRLFKDANDMLDKLSAEKTLNPRGV 998
Query: 3061 VSFLPAASEGDDMHVYDPET-GNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDD 3237
V PA GDD+ +Y ET + ++ + LRQQ+ + ++CL+DF+ P +G D
Sbjct: 999 VGLFPANRVGDDIEIYRDETRTHVINVSHHLRQQT-EKTGFANYCLADFVAPKLSG-KAD 1056
Query: 3238 YLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYST 3417
Y+G FA T GL + E HDDY IMVKALADRLAEA+AEYLH+ VR WGY+
Sbjct: 1057 YIGAFAVTGGLEEDALADAFEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAP 1116
Query: 3418 NEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKN-GIGLTEHLAMLPAAS 3594
NE+L+ +L+ YQGIRPA GYP+ P+HTEK T+W+LLE EK+ G+ LTE AM P AS
Sbjct: 1117 NENLSNEELIRENYQGIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGAS 1176
Query: 3595 VSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGYDTD 3747
VSG YF++P S+Y+AV +I +DQV D+A RK + +VERWL+P LGYD D
Sbjct: 1177 VSGWYFSHPDSKYYAVAQIQRDQVEDHARRKGMSVSDVERWLAPNLGYDAD 1227
>gi|24115293|ref|NP_709803.1| B12-dependent
homocysteine-N5-methyltetrahydrofolate transmethylase,
repressor of metE and metF [Shigella flexneri 2a str.
301]
gi|24054589|gb|AAN45510.1| B12-dependent
homocysteine-N5-methyltetrahydrofolate transmethylase,
repressor of metE and metF [Shigella flexneri 2a str.
301]
Length = 1232
Score = 1239 bits (3207), Expect = 0.0
Identities = 657/1251 (52%), Positives = 848/1251 (67%), Gaps = 5/1251 (0%)
Frame = +1
Query: 10 SSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRP 189
SS E+L ERI+++DG MGTMIQ + E DFRGE D LKGNNDLL +++P
Sbjct: 7 SSKVEQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSKP 66
Query: 190 DIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAA 369
++I IH Y EAGAD +ETNTF+ TTIA ADY+ E L EIN+ +A +AR D+ A
Sbjct: 67 EVIAAIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTAR 126
Query: 370 TGRR-RYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVE 546
T + RYV G +GPTNRT SISP V P FRN+TF +L AY + ++L++GG D++L+E
Sbjct: 127 TPEKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLAAAYRESTKALVEGGADLILIE 186
Query: 547 TVFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKP 726
TVFD+ NAKAA+FA++T FE GV E+P+ +SGTI D SGRTLSGQT EAF S + +
Sbjct: 187 TVFDTLNAKAAVFAVKTEFEALGV-ELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEA 245
Query: 727 MAVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFAR 906
+ GLNCALG ++RQ+V +S+ ++ ++ +PNAGLPNA G YD + MA +RE+A+
Sbjct: 246 LTFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAQ 305
Query: 907 DGLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVN 1086
G +NI+GGCCGTTP HI AM +AV+G+ PR P+ P A + LSGLEP +G ++ FVN
Sbjct: 306 AGFLNIVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACR--LSGLEPLNIGDDSLFVN 363
Query: 1087 IGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLR 1266
+GER NV GS +F LIK E Y A+DVAR QV++GAQI+D+NMD+G+LD AM +FL
Sbjct: 364 VGERTNVTGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLN 423
Query: 1267 LISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGA 1446
LI+ EPD+A++P+ IDSS +DVI GL+ QGK +VNSIS+KEG + F A++++RYGA
Sbjct: 424 LIAGEPDIARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGA 483
Query: 1447 AVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNY 1626
AVVVMAFDEQGQA K EIC R+Y+ILTEEVGF P DIIFD NI +ATG+EEH+NY
Sbjct: 484 AVVVMAFDEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNY 543
Query: 1627 GMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVN 1806
FI A I+ LP A +SGGVSN+SFSFRG + +REA+H+VFL+YAI+ GMDMGIVN
Sbjct: 544 AQDFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVN 603
Query: 1807 AGALPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEM--XXXXXXXXXXXXEWRSLT 1980
AG L +Y+D+ NR + TE+LL A++ EWRS
Sbjct: 604 AGQLAIYDDLPAELRDAVEDVILNRRDDGTERLLELAEKYRGSKADDTANAQQAEWRSWD 663
Query: 1981 VEERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFL 2160
V +RL+++LVKG+ +F+ DTEEARQ RP+ VIE PLMDGM VVG+LFG GKMFL
Sbjct: 664 VNKRLEYSLVKGITEFIEQDTEEARQQAT---RPIEVIEGPLMDGMNVVGDLFGEGKMFL 720
Query: 2161 PQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKN 2340
PQV+KSARVMK+AVA+L PF+E ++++ G +VIATVKGDVHDIGKN
Sbjct: 721 PQVVKSARVMKQAVAYLEPFIE-----------ASKEQGKTNGKMVIATVKGDVHDIGKN 769
Query: 2341 IVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRV 2520
IV VVL CNN+++VDLGVM P E I++ A E AD IGLSGLITPSLDEMV VAKEM R
Sbjct: 770 IVGVVLQCNNYEIVDLGVMVPAEKILRIAKEVNADLIGLSGLITPSLDEMVNVAKEMERQ 829
Query: 2521 GLNIPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLN 2700
G IPLLIGGATTSK HTAVKI Y P V+ +AS++V V ++L + RD F+
Sbjct: 830 GFAIPLLIGGATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTC 889
Query: 2701 EDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIP 2880
++YE VR +H L R+ F DW +T +G +E + + L
Sbjct: 890 KEYETVRIQHGRKKPRTPPVTLEAARDNDFAFDWQAYTPPVAHRLGVQEVE-ASIETLRN 948
Query: 2881 YIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAV 3060
YIDW PFF W L GK YP+I +D VG EA+++F DA L KL EK L V
Sbjct: 949 YIDWTPFFMTWSLAGK-----YPRILEDEVVGVEAQRLFKDANDMLDKLSAEKTLNPRGV 1003
Query: 3061 VSFLPAASEGDDMHVYDPET-GNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDD 3237
V PA GDD+ +Y ET + ++ + LRQQ+ + ++CL+DF+ P +G D
Sbjct: 1004 VGLFPANRVGDDIEIYRDETRTHVINVSHHLRQQT-EKTGFANYCLADFVAPKLSG-KAD 1061
Query: 3238 YLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYST 3417
Y+G FA T GL + E HDDY IMVKALADRLAEA+AEYLH+ VR WGY+
Sbjct: 1062 YIGAFAVTGGLEEDALADAFEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAP 1121
Query: 3418 NEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKN-GIGLTEHLAMLPAAS 3594
NE+L+ +L+ YQGIRPA GYP+ P+HTEK T+W+LLE EK+ G+ LTE AM P AS
Sbjct: 1122 NENLSNEELIRENYQGIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGAS 1181
Query: 3595 VSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGYDTD 3747
VSG YF++P S+Y+AV +I +DQV D+A RK + +VERWL+P LGYD D
Sbjct: 1182 VSGWYFSHPDSKYYAVAQIQRDQVEDHARRKGMSVSDVERWLAPNLGYDAD 1232
>gi|13540426|gb|AAK29461.1| MetH [Pseudomonas putida]
Length = 1237
Score = 1238 bits (3204), Expect = 0.0
Identities = 659/1257 (52%), Positives = 854/1257 (67%), Gaps = 11/1257 (0%)
Frame = +1
Query: 7 RSSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITR 186
RS+ + L KERI+I+DG MGTMIQ +EE D+RG D +KGNNDLL ++R
Sbjct: 4 RSARLQALQNALKERILILDGGMGTMIQSYRLEEHDYRGTRFADWPSDVKGNNDLLLLSR 63
Query: 187 PDIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGA 366
PD+I I K YL+AGAD +ETNTF+ T I+QADY E LV+E+N + A +AR+ D
Sbjct: 64 PDVIAAIEKAYLDAGADILETNTFNATQISQADYGMESLVYELNVEGARIARQVADAKTL 123
Query: 367 AT-GRRRYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLV 543
T + R+V G +GPT+RT SISP V P FRNVTF ELV+ Y + R LI+GG D++L+
Sbjct: 124 ETPDKPRFVAGVLGPTSRTCSISPDVNDPGFRNVTFDELVENYIEATRGLIEGGADLILI 183
Query: 544 ETVFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGK 723
ET+FD+ NAKAA+FA++ +FED+ V E+P+ +SGTI D SGRTLSGQT EAF S + K
Sbjct: 184 ETIFDTLNAKAAIFAVQQVFEDDNV-ELPIMISGTITDASGRTLSGQTTEAFWNSVRHAK 242
Query: 724 PMAVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFA 903
P++VGLNCALGAKD+R +++ ++ +D+ + +PNAGLPNA G YDETP EMA V+ EFA
Sbjct: 243 PISVGLNCALGAKDLRPYLEELATKADTHVSAHPNAGLPNAFGEYDETPAEMAAVVEEFA 302
Query: 904 RDGLVNIIGGCCGTTPDHIN--AMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETN 1077
G +NIIGGC GTTP HI A+ +AV PR P+ A + LSGLEP + ++
Sbjct: 303 ASGFLNIIGGCLGTTPGHIQIQAIAEAVAKYKPREIPEIAKACR--LSGLEPFTIDRQSL 360
Query: 1078 FVNIGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSK 1257
FVN+GER N+ GS +F LI+ ENY A++VA QV++GAQ++D+NMD+G+LD AM +
Sbjct: 361 FVNVGERTNITGSAKFARLIREENYTEALEVALQQVEAGAQVIDINMDEGMLDSQAAMVR 420
Query: 1258 FLRLISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKR 1437
FL LI+ EPD++++P+ IDSS ++VI AGL+ QGK +VNSIS+KEG E+FK AR+ KR
Sbjct: 421 FLNLIAGEPDISRVPIMIDSSKWEVIEAGLKCIQGKGIVNSISMKEGVEQFKHHARLCKR 480
Query: 1438 YGAAVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEH 1617
YGAAVVVMAFDE GQA K EIC+RSY IL EVGF P DIIFD NI +ATG+EEH
Sbjct: 481 YGAAVVVMAFDEVGQADTAARKKEICQRSYDILVNEVGFPPEDIIFDPNIFAVATGIEEH 540
Query: 1618 SNYGMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMG 1797
+NY + FIEA IR++LP A SGGVSN+SFSFRG +REA+HSVFL++AI+ G+ MG
Sbjct: 541 NNYAVDFIEACAYIRDHLPHALSSGGVSNVSFSFRGNNPVREAIHSVFLYHAIQNGLTMG 600
Query: 1798 IVNAGALPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEMXXXXXXXXXXXXEWRSL 1977
IVNAG L +Y++I NR P T+ LL A + EWRSL
Sbjct: 601 IVNAGQLEIYDEIPAQLREKVEDVVLNRTPHGTDALLAIADDYKGGGATKEVENEEWRSL 660
Query: 1978 TVEERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMF 2157
VE+RL+ ALVKG+ F+V DTEE RQ A RP+ VIE PLM+GM VVG+LFGAGKMF
Sbjct: 661 PVEKRLEHALVKGITAFIVEDTEECRQQCA---RPIEVIEGPLMNGMNVVGDLFGAGKMF 717
Query: 2158 LPQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGK 2337
LPQV+KSARVMK+AVAHL+PF+E E+ D+ +G +++ATVKGDVHDIGK
Sbjct: 718 LPQVVKSARVMKQAVAHLIPFIEAEK----------GDKPEAKGKILMATVKGDVHDIGK 767
Query: 2338 NIVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNR 2517
NI VVLGCN + +V GV P E I++ A E+K D IGLSGLITPSLDEMV+VA+EM R
Sbjct: 768 NIFGVVLGCNGYDIVGPGVTVPAEKILQTAREQKCDIIGLSGLITPSLDEMVHVAREMQR 827
Query: 2518 VGLNIPLLIGGATTSKTHTAVKISPRYPH-PVVHCLDASKSVVVCSSLSDMSVRDAFLQD 2694
G +PL+IGGATTSK HTAVKI P+Y + V++ DAS++V V + L ++ F++
Sbjct: 828 QGFELPLMIGGATTSKAHTAVKIEPKYSNDAVIYVTDASRAVGVATQLLSKELKPGFVEK 887
Query: 2695 LNEDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNEL 2874
+Y DVR+ + K + DW + PSF G + ++ DL L
Sbjct: 888 TRLEYVDVRERTANRSARTERLSYAQAIAAKPQYDWASYQPAVPSFTGVKVLEDIDLRTL 947
Query: 2875 IPYIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVAN 3054
YIDW PFF W L GK +P+I D VG A ++ DA+ L KLIDEK++ A
Sbjct: 948 AEYIDWTPFFISWDLAGK-----FPRILTDEVVGEAATALYKDAREMLDKLIDEKLISAR 1002
Query: 3055 AVVSFLPAAS-EGDDMHVYDPETGNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVP 3231
AV F PA DD+ VY E G L T + LRQQ+ + +P++ L+DF+ P +GV
Sbjct: 1003 AVFGFWPANQVADDDIEVYG-EDGQALATLHHLRQQTIKPDGKPNWSLADFVAPKDSGV- 1060
Query: 3232 DDYLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGY 3411
DY+G F TAG+GAEE K + DDY+SIMVKALADRLAEA AE+LH++VR WGY
Sbjct: 1061 TDYVGGFITTAGIGAEEVAKAYQDKGDDYSSIMVKALADRLAEACAEWLHEQVRKEHWGY 1120
Query: 3412 STNEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLL------EAEKNGIGLTEHL 3573
+ +E L L+ +Y GIRPA GYP+ PDHTEK TL++LL E +G+ LTEH
Sbjct: 1121 ARDEHLDNEALIKEQYSGIRPAPGYPACPDHTEKETLFRLLDGTAIGETGPSGVYLTEHF 1180
Query: 3574 AMLPAASVSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGYDT 3744
AM PAA+VSG YFA+PQ++YFAVGK+D+DQ+ Y+ARK ERWL+P LGYD+
Sbjct: 1181 AMFPAAAVSGWYFAHPQAKYFAVGKVDKDQIERYSARKGQDISVSERWLAPNLGYDS 1237
>gi|46914822|emb|CAG21599.1| putative cobalamin-dependent methionine
synthase [Photobacterium profundum]
Length = 1223
Score = 1231 bits (3184), Expect = 0.0
Identities = 645/1241 (51%), Positives = 849/1241 (67%), Gaps = 4/1241 (0%)
Frame = +1
Query: 22 EELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRPDIIY 201
E L + E I+IIDG MGTMIQ ++E D+RGE D LKGNNDLL +T+P +I
Sbjct: 7 EILQKRLAENILIIDGGMGTMIQGYKLDENDYRGERFADWHSDLKGNNDLLVLTQPQLIK 66
Query: 202 KIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAAT-GR 378
IH YLEAGAD +ETNTF+ TTIA ADY E L EIN+++A +AR+A D+ T +
Sbjct: 67 DIHNEYLEAGADILETNTFNATTIAMADYDMESLSAEINFEAAKLARQAADEWTLKTPSK 126
Query: 379 RRYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVETVFD 558
R+V G +GPTNRT SISP V P FRNVTF +LV+AY + R+LI GGVD++LVET+FD
Sbjct: 127 PRFVAGVLGPTNRTCSISPDVNDPSFRNVTFDQLVEAYSESTRALIAGGVDLILVETIFD 186
Query: 559 SANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKPMAVG 738
+ NAKA FA+ T+F+++GV +P+ +SGTI D SGRTLSGQT EAF S + KP++ G
Sbjct: 187 TLNAKACTFAVETVFDEDGVV-LPIMISGTITDASGRTLSGQTTEAFYNSLRHVKPISFG 245
Query: 739 LNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFARDGLV 918
LNCALG ++RQ+VD +S+ S+S + +PNAGLPNA G YD +PE+MA+ + E+A+ G +
Sbjct: 246 LNCALGPDELRQYVDELSRISESAVSAHPNAGLPNAFGEYDLSPEDMAEHIEEWAKSGFL 305
Query: 919 NIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVNIGER 1098
N++GGCCGTTP+HI M + + + PR P P A + LSGLEP + +T FVN+GER
Sbjct: 306 NLVGGCCGTTPEHIRLMEQVTRNVKPRQLPDIPIACR--LSGLEPLTISADTLFVNVGER 363
Query: 1099 CNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLRLISS 1278
NV GS RF LIK+E YD A++VAR QV++GAQI+D+NMD+G+LD AM +FL L ++
Sbjct: 364 TNVTGSARFKRLIKDELYDEALEVARQQVEAGAQIIDINMDEGMLDAEAAMVRFLNLCAT 423
Query: 1279 EPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGAAVVV 1458
EP+++K+P+ +DSS ++++ AGL+ QGK +VNSIS+KEG EKF +A++I+RYGAAV+V
Sbjct: 424 EPEISKVPIMVDSSKWEILEAGLKCIQGKPIVNSISMKEGVEKFIAQAKLIRRYGAAVIV 483
Query: 1459 MAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNYGMYF 1638
MAFDE+GQA + K EIC +Y IL EVGF P DIIFD NI +ATG+EEH+NY + F
Sbjct: 484 MAFDEEGQADTRERKIEICTNAYHILVNEVGFPPEDIIFDPNIFAVATGIEEHNNYAVDF 543
Query: 1639 IEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVNAGAL 1818
IEA I+ LP A VSGGVSN+SFSFRG + IREA+H+VFL+Y K GMDMGIVNAG L
Sbjct: 544 IEAVGDIKRTLPYAMVSGGVSNVSFSFRGNDPIREAIHAVFLYYCFKNGMDMGIVNAGQL 603
Query: 1819 PVYEDIDKPXXXXXXXXXFNRDPEATEKLL-VAAQEMXXXXXXXXXXXXEWRSLTVEERL 1995
+Y+D+ NR ++TE+LL +A + EWR VE+RL
Sbjct: 604 AIYDDLTDELRNAVEDVVLNRRDDSTERLLDIAEKYRGSGKVEEDRTLQEWRGWPVEKRL 663
Query: 1996 KFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFLPQVIK 2175
ALVKG+ +F+V DTEEAR N +K PL VIE PLM GM +VG+LF GKMFLPQV+K
Sbjct: 664 SHALVKGITEFIVEDTEEARTNASK---PLEVIEGPLMAGMNIVGDLFSEGKMFLPQVVK 720
Query: 2176 SARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKNIVSVV 2355
SARVMK+AVAHL P++ E+QA G +++ATVKGDVHDIGKNIV VV
Sbjct: 721 SARVMKQAVAHLEPYINAEKQAGYT-----------NGKILLATVKGDVHDIGKNIVGVV 769
Query: 2356 LGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRVGLNIP 2535
L CNN++++DLGVM CE I+K A E+ D IGLSGLITPSLDEMV+VAKEM R G +P
Sbjct: 770 LQCNNYEIIDLGVMVSCEKILKVAKEKNVDIIGLSGLITPSLDEMVHVAKEMERQGFELP 829
Query: 2536 LLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLNEDYED 2715
LLIGGATTSK HTAVKI Y PVV+ +AS++V VCS+L +R AF++ L+++Y
Sbjct: 830 LLIGGATTSKAHTAVKIEENYHGPVVYVSNASRAVGVCSALLSDVLRPAFIERLDKEYIT 889
Query: 2716 VRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIPYIDWK 2895
VR++H L + RE K IDW+ +T P G + +F ++++ YIDW
Sbjct: 890 VREQHARKKPRTPPVTLEQARENKVAIDWESYTPPAPVKPGIHVFTDFPISKIRKYIDWT 949
Query: 2896 PFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAVVSFLP 3075
PFF W L GKYP I VG EA+++FDDA L ++ ++ AN V P
Sbjct: 950 PFFMTWSLSGKYPT-----ILRHEVVGEEAQRLFDDANVLLDEIERTGMIKANGVCGLFP 1004
Query: 3076 AASEGDDMHVYDPETGNKLDT-FYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDDYLGLF 3252
A + GDD+ VY ET +++ T GLRQQ+ ++ P++CLSD+I P K D++G F
Sbjct: 1005 ANNIGDDIEVYTDETRSEVMTVLCGLRQQT-KKPKGPNYCLSDYIAP-KESNKADWIGAF 1062
Query: 3253 ACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYSTNEDLT 3432
A T G+G + + + DDY +IMV+A+ADRLAEA+AE +H+ VR +WGY+ E L
Sbjct: 1063 AVTGGIGEYDIAEQFKAKGDDYNAIMVQAIADRLAEAFAECMHETVRKDIWGYAPEESLA 1122
Query: 3433 ESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKN-GIGLTEHLAMLPAASVSGLY 3609
DL+ KYQGIRPA GYP+ P+HTEK +W LL+AE N G+ LTE AM P A+VSG Y
Sbjct: 1123 NEDLIREKYQGIRPAPGYPACPEHTEKGAIWTLLDAEANTGMVLTESYAMWPGAAVSGWY 1182
Query: 3610 FANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPIL 3732
F++P+S YFAV +I DQ YA RK + E+WL P L
Sbjct: 1183 FSHPESRYFAVAQIQTDQRDSYADRKGWDLLDAEKWLGPNL 1223
>gi|50122907|ref|YP_052074.1| 5-methyltetrahydrofolate--homocysteine
methyltransferase [Erwinia carotovora subsp. atroseptica
SCRI1043]
gi|49613433|emb|CAG76884.1| 5-methyltetrahydrofolate--homocysteine
methyltransferase [Erwinia carotovora subsp. atroseptica
SCRI1043]
Length = 1227
Score = 1229 bits (3179), Expect = 0.0
Identities = 657/1253 (52%), Positives = 843/1253 (66%), Gaps = 7/1253 (0%)
Frame = +1
Query: 10 SSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRP 189
S+ +EL +RIM++DG MGTMIQ ++E D+RGE D +KGNNDLL +TRP
Sbjct: 2 SNRVDELRRQLAQRIMVLDGGMGTMIQGYRLQEADYRGERFADWPSDVKGNNDLLVLTRP 61
Query: 190 DIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAA 369
+I +IH YLEAGAD +ETNTF+ TTIA ADY L EIN +A +AR + D A
Sbjct: 62 QVISEIHNAYLEAGADILETNTFNSTTIAMADYDMASLSAEINTVAAQLARASADKWTAL 121
Query: 370 T-GRRRYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVE 546
T + RYV G +GPTNRT SISP V P FRNV+F +LV+AY + R+LI GGVD++++E
Sbjct: 122 TPDKPRYVAGVLGPTNRTASISPDVNDPAFRNVSFDQLVEAYRESTRALIAGGVDLIMIE 181
Query: 547 TVFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKP 726
T+FD+ NAKAA FA+ + FE G+ +PV +SGTI D SGRTLSGQT EAF S + +P
Sbjct: 182 TIFDTLNAKAASFAVESEFEALGIV-LPVMISGTITDASGRTLSGQTTEAFYNSLRHSRP 240
Query: 727 MAVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFAR 906
++ GLNCALG ++RQ+V +S+ S+ ++ +PNAGLPNA G YD P +MA + E+AR
Sbjct: 241 LSFGLNCALGPDELRQYVAELSRISECYVSAHPNAGLPNAFGEYDLDPADMAKHIGEWAR 300
Query: 907 DGLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVN 1086
G +NI+GGCCG+TP HI AM K V+G+ PR P+ P A + LSGLEP + T FVN
Sbjct: 301 SGFLNIVGGCCGSTPAHIAAMAKVVEGVPPRKLPEIPVACR--LSGLEPLTIDANTLFVN 358
Query: 1087 IGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLR 1266
+GER NV GS RF LIK E Y+ A+DVAR QV+SGAQI+D+NMD+G+LD AM++FL
Sbjct: 359 VGERTNVTGSARFKRLIKEEKYNEALDVARQQVESGAQIIDINMDEGMLDAEAAMTRFLN 418
Query: 1267 LISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGA 1446
LI+ EPD+A++P+ IDSS +DV+ GL+ QGK +VNSIS+KEG E F A++++RYGA
Sbjct: 419 LIAGEPDIARVPIMIDSSKWDVVEKGLKCIQGKGIVNSISMKEGVEAFIHHAKLVRRYGA 478
Query: 1447 AVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNY 1626
AVVVMAFDE GQA K EIC R+YRILTEEVGF P DIIFD NI +ATG++EH+NY
Sbjct: 479 AVVVMAFDEVGQADTRARKIEICRRAYRILTEEVGFPPEDIIFDPNIFAVATGIDEHNNY 538
Query: 1627 GMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVN 1806
+ FIEA I+ LP A +SGGVSN+SFSFRG + +REA+H+VFL+YAI+ GMDMGIVN
Sbjct: 539 AVDFIEACADIKAQLPHAMISGGVSNVSFSFRGNDLVREAIHAVFLYYAIRNGMDMGIVN 598
Query: 1807 AGALPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEM--XXXXXXXXXXXXEWRSLT 1980
A L +Y+D+ NR +ATE++L A++ EWR
Sbjct: 599 ASQLAIYDDLPAELRDAVEDVILNRRSDATERMLELAEKYRGSKTEDEGSKTQAEWRGWD 658
Query: 1981 VEERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFL 2160
V++RL+++LVKG+ +F+ DTEEARQ + RP+ VIE PLMDGM VVG+LFGAGKMFL
Sbjct: 659 VKKRLEYSLVKGITEFIELDTEEARQQAS---RPIEVIEGPLMDGMNVVGDLFGAGKMFL 715
Query: 2161 PQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKN 2340
PQV+KSARVMK+AVA+L P+++ ++D+ G +++ATVKGDVHDIGKN
Sbjct: 716 PQVVKSARVMKQAVAYLEPYID-----------ASKDKGSSAGKILLATVKGDVHDIGKN 764
Query: 2341 IVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRV 2520
IV VVL CNN++++DLGVM P + I+K A EEK D IGLSGLITPSLDEMV VAKEM R
Sbjct: 765 IVGVVLQCNNYEIIDLGVMVPTDKILKTAREEKVDIIGLSGLITPSLDEMVNVAKEMERQ 824
Query: 2521 GLNIPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLN 2700
G +PLLIGGATTSK HTAVKI Y P V+ +AS+SV V S+L + F+
Sbjct: 825 GFTLPLLIGGATTSKAHTAVKIEQNYSGPTVYVQNASRSVGVVSALLSSTQYGDFVARTR 884
Query: 2701 EDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQ--NFDLNEL 2874
++YE VR +H L R +DW+ +T P R Q ++ L
Sbjct: 885 KEYETVRIQHARKKPRTPPVTLEAARANASDLDWENYT---PPIAHRPGVQAVTANIETL 941
Query: 2875 IPYIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVAN 3054
YIDW PFF W L GK YP+I +D VG EAK++F DA L L L
Sbjct: 942 RNYIDWTPFFMTWSLAGK-----YPRILEDDVVGEEAKRLFADANAMLDDLSARGALNPR 996
Query: 3055 AVVSFLPAASEGDDMHVY-DPETGNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVP 3231
VV PA GDD+ +Y D L + LRQQ+ + D P++CLSDF+ P +G P
Sbjct: 997 GVVGLFPANRVGDDVVIYTDERRETVLSVSHHLRQQT-EKPDFPNYCLSDFVAPKSSGKP 1055
Query: 3232 DDYLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGY 3411
DYLG FA T GL + E HDDY IMVKA++DRLAEA+AEYLH+ VR WGY
Sbjct: 1056 -DYLGAFAVTGGLEEDALADLWEAQHDDYNKIMVKAISDRLAEAFAEYLHERVRKVYWGY 1114
Query: 3412 STNEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKN-GIGLTEHLAMLPA 3588
+ NE+L+ L+ YQG+RPA GYP+ PDHTEK +W+LL+ EK+ G+ LTE AM P
Sbjct: 1115 APNENLSNELLIRENYQGVRPAPGYPACPDHTEKVQIWQLLDVEKHTGMKLTESYAMWPG 1174
Query: 3589 ASVSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGYDTD 3747
ASVSG YF++P S+YFAV +I +DQV DYA RK + EVERWL+P LGYD D
Sbjct: 1175 ASVSGWYFSHPDSKYFAVAQIQRDQVEDYAVRKGMNVGEVERWLAPNLGYDAD 1227
>gi|13366027|dbj|BAB39355.1| cobalamin-dependent methionine synthase
[Vibrio fischeri]
Length = 1226
Score = 1228 bits (3178), Expect = 0.0
Identities = 642/1249 (51%), Positives = 851/1249 (67%), Gaps = 5/1249 (0%)
Frame = +1
Query: 1 MTRSSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSI 180
M S++ ++ + ERI++IDG MGTMIQ EE+D+RG LKGNNDLL +
Sbjct: 1 MAGSNIKVQIEKQLSERILLIDGGMGTMIQGYKFEEKDYRGGRFNQWHCDLKGNNDLLVL 60
Query: 181 TRPDIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDV 360
++P II IH+ YLEAGAD +ETNTF+ TTIA ADY E L EIN+++A +AR D
Sbjct: 61 SQPQIIRDIHEAYLEAGADILETNTFNATTIAMADYDMESLSEEINFEAAKLAREVADKW 120
Query: 361 GAATGRR-RYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVL 537
T + RYV G +GPTNRT SISP V P FRNV+F ELV+AY + R+LI+GG D++
Sbjct: 121 TEKTPNKPRYVAGVLGPTNRTCSISPDVNDPGFRNVSFDELVEAYSESTRALIRGGSDLI 180
Query: 538 LVETVFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQ 717
L+ET+FD+ NAKA FA+ ++FE+ G+ +PV +SGTI D SGRTLSGQT EAF + +
Sbjct: 181 LIETIFDTLNAKACSFAVESVFEELGIT-LPVMISGTITDASGRTLSGQTTEAFYNALRH 239
Query: 718 GKPMAVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLRE 897
KP++ GLNCALG ++R++V +S+ S+ ++ +PNAGLPNA G YD +PE+MA+ + E
Sbjct: 240 VKPISFGLNCALGPDELREYVSELSRISECYVSAHPNAGLPNAFGEYDLSPEDMAEHVAE 299
Query: 898 FARDGLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETN 1077
+A G +N+IGGCCGTTP+HI M V+G+ PR P+ P A + LSGLEP + ++
Sbjct: 300 WASSGFLNLIGGCCGTTPEHIRQMALVVEGVKPRQLPELPVACR--LSGLEPLTIEKDSL 357
Query: 1078 FVNIGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSK 1257
F+N+GER NV GS RF LIK E YD A+ VA+ QV++GAQI+D+NMD+G+LD M +
Sbjct: 358 FINVGERTNVTGSARFKRLIKEELYDEALSVAQEQVENGAQIIDINMDEGMLDAEACMVR 417
Query: 1258 FLRLISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKR 1437
FL L +SEP+++K+PV +DSS ++VI AGL+ QGK +VNSISLKEG+EKF +A++I+R
Sbjct: 418 FLNLCASEPEISKVPVMVDSSKWEVIEAGLKCIQGKGIVNSISLKEGKEKFVHQAKLIRR 477
Query: 1438 YGAAVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEH 1617
YGAAV+VMAFDE GQA + K EIC +Y IL +EVGF P DIIFD NI +ATG++EH
Sbjct: 478 YGAAVIVMAFDEVGQADTRERKIEICTNAYNILVDEVGFPPEDIIFDPNIFAVATGIDEH 537
Query: 1618 SNYGMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMG 1797
+NY + FIEA I+ LP A +SGGVSN+SFSFRG +REA+H+VFL++ K GMDMG
Sbjct: 538 NNYAVDFIEAVGDIKRTLPHAMISGGVSNVSFSFRGNNYVREAIHAVFLYHCFKNGMDMG 597
Query: 1798 IVNAGALPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEM--XXXXXXXXXXXXEWR 1971
IVNAG L +Y+++ + NR ++TE+LL A E EWR
Sbjct: 598 IVNAGQLEIYDNVPEDLREAVEDVVLNRRDDSTERLLDIATEYLERAVGKVEDKSALEWR 657
Query: 1972 SLTVEERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGK 2151
VE+RL+ +LVKG+ +F+V DTEEAR N RP+ VIE PLMDGM VVG+LFG GK
Sbjct: 658 DWPVEKRLEHSLVKGITEFIVEDTEEARINA---ERPIEVIEGPLMDGMNVVGDLFGEGK 714
Query: 2152 MFLPQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDI 2331
MFLPQV+KSARVMK+AVAHL PF+ ++ G +++ATVKGDVHDI
Sbjct: 715 MFLPQVVKSARVMKQAVAHLEPFINASKEVGAT-----------NGKILLATVKGDVHDI 763
Query: 2332 GKNIVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEM 2511
GKNIV VVL CNN++++DLGVM CE I+K A EE D IGLSGLITPSLDEMV+VAKEM
Sbjct: 764 GKNIVGVVLQCNNYEIIDLGVMVSCETILKVAKEENVDIIGLSGLITPSLDEMVHVAKEM 823
Query: 2512 NRVGLNIPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQ 2691
R G ++PLLIGGATTSK HTAVKI Y PVV+ +AS++V VC+SL ++ +F++
Sbjct: 824 ERQGFDLPLLIGGATTSKAHTAVKIEQNYSQPVVYVNNASRAVGVCTSLLSNELKPSFVE 883
Query: 2692 DLNEDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNE 2871
L+ DYE VR++H + L R K IDW +T P G + NFD++
Sbjct: 884 KLDIDYERVREQHSRKQPRTKPVTLEVARANKVAIDWASYTPPVPLKPGVHIFDNFDVST 943
Query: 2872 LIPYIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVA 3051
L YIDW PFF W L GK YPKI + +VG EAK++F DA L ++ E +L A
Sbjct: 944 LRNYIDWTPFFMTWSLVGK-----YPKILEHEEVGEEAKRLFKDANDLLDRVEKEGLLKA 998
Query: 3052 NAVVSFLPAASEGDDMHVYDPETGNKL-DTFYGLRQQSGREHDQPHFCLSDFIKPLKNGV 3228
+ + PA+S GDD+ VY E+ + + LRQQ+ + ++CLSD+I P ++G
Sbjct: 999 RGMCALFPASSVGDDIEVYTDESRTTVAKVLHNLRQQTEKPKGF-NYCLSDYIAPKESG- 1056
Query: 3229 PDDYLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWG 3408
+D++G FA T G+G E + N DDY +IM++A+ADRLAEA+AEYLH++VR +WG
Sbjct: 1057 KNDWIGGFAVTGGIGERELADEYKANGDDYNAIMIQAVADRLAEAFAEYLHEKVRKEIWG 1116
Query: 3409 YSTNEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKN-GIGLTEHLAMLP 3585
YS NE L+ DL+ KYQGIRPA GYP+ P+HTEK LW+L+ E++ G+ LT AM P
Sbjct: 1117 YSPNETLSNDDLIREKYQGIRPAPGYPACPEHTEKGALWELMNVEESIGMSLTSSYAMWP 1176
Query: 3586 AASVSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPIL 3732
ASVSG+YF++P S YFA+ +I QDQ YA RK E E+WL P L
Sbjct: 1177 GASVSGMYFSHPDSRYFAIAQIQQDQAESYADRKGWNMLEAEKWLGPNL 1225
>gi|16123860|ref|NP_407173.1| 5-Methyltetrahydrofolate--homocysteine
methyltransferase [Yersinia pestis]
gi|22123942|ref|NP_667365.1| B12-dependent
homocysteine-N5-methyltetrahydrofolate transmethylase,
repressor of metE and metF [Yersinia pestis KIM]
gi|45442838|ref|NP_994377.1| 5-Methyltetrahydrofolate--homocysteine
methyltransferase [Yersinia pestis biovar Medievalis str.
91001]
gi|25285957|pir||AB0453 5-methyltetrahydrofolate-homocysteine
S-methyltransferase (EC 2.1.1.13) [imported] - Yersinia
pestis (strain CO92)
gi|15981639|emb|CAC93190.1| 5-Methyltetrahydrofolate--homocysteine
methyltransferase [Yersinia pestis CO92]
gi|21956678|gb|AAM83616.1| B12-dependent
homocysteine-N5-methyltetrahydrofolate transmethylase,
repressor of metE and metF [Yersinia pestis KIM]
gi|45437704|gb|AAS63254.1| 5-Methyltetrahydrofolate--homocysteine
methyltransferase [Yersinia pestis biovar Medievalis str.
91001]
Length = 1231
Score = 1225 bits (3170), Expect = 0.0
Identities = 652/1246 (52%), Positives = 841/1246 (67%), Gaps = 4/1246 (0%)
Frame = +1
Query: 22 EELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRPDIIY 201
+EL + +RI+++DG MGTMIQ +EE D+RG D LKGNNDLL +++P++I
Sbjct: 11 KELHQQLAQRILVLDGGMGTMIQSYRLEEADYRGARFADWASDLKGNNDLLVLSKPEVIT 70
Query: 202 KIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAATGRR 381
IH YLEAGAD +ETNTF+ T+IA ADY+ L EINY++A +AR D+ A T +
Sbjct: 71 AIHNAYLEAGADILETNTFNSTSIAMADYQMASLSAEINYEAARLARICADEWSARTPEK 130
Query: 382 -RYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVETVFD 558
RYV G +GPTNRT SISP V P FRNV+F +LV+AY + R+LI+GGVD++++ETVFD
Sbjct: 131 PRYVAGVLGPTNRTASISPKVNDPAFRNVSFDQLVEAYRESTRALIEGGVDLIMIETVFD 190
Query: 559 SANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKPMAVG 738
+ NAKAA FA+ + FE GV +PV +SGTI D SGRTLSGQT EAF S + KP++ G
Sbjct: 191 TLNAKAATFAVESEFEVMGVL-LPVMISGTITDASGRTLSGQTTEAFYNSLRHVKPLSFG 249
Query: 739 LNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFARDGLV 918
LNCALG ++RQ+V +S+ S+ ++ +PNAGLPNA G YD +EMA+ + E+AR G +
Sbjct: 250 LNCALGPDELRQYVAELSRISEYYVSAHPNAGLPNAFGEYDLEAKEMAEQIGEWARAGFL 309
Query: 919 NIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVNIGER 1098
NI+GGCCGTTP HI AM AV G+ PR P P A + L+GLEP + T FVN+GER
Sbjct: 310 NIVGGCCGTTPRHIAAMVNAVAGVPPRPLPDIPVACR--LAGLEPLTIDANTLFVNVGER 367
Query: 1099 CNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLRLISS 1278
NV GS RF LIK E Y A+DVAR QV+SGAQI+D+NMD+G+LD AM +FL LI+
Sbjct: 368 TNVTGSARFKRLIKEEKYGEALDVARQQVESGAQIIDINMDEGMLDAEAAMVRFLNLIAG 427
Query: 1279 EPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGAAVVV 1458
EPD+A++P+ IDSS +DVI GL+ QGK +VNSIS+KEG + F A++++RYGAA+VV
Sbjct: 428 EPDIARVPIMIDSSRWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLVRRYGAAMVV 487
Query: 1459 MAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNYGMYF 1638
MAFDE GQA K EIC R+Y+ILTE VGF P DIIFD NI +ATG+EEH+NY + F
Sbjct: 488 MAFDETGQADTRARKIEICRRAYKILTETVGFPPEDIIFDPNIFAVATGIEEHNNYAVDF 547
Query: 1639 IEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVNAGAL 1818
IEA I+ LP A +SGGVSN+SFSFRG + +REA+H+VFL+YAI+ GMDMGIVNAG L
Sbjct: 548 IEACADIKAELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQL 607
Query: 1819 PVYEDIDKPXXXXXXXXXFNRDPEATEKLL-VAAQEMXXXXXXXXXXXXEWRSLTVEERL 1995
+Y+D+ NR ++TE+LL +A + EWR V +RL
Sbjct: 608 AIYDDLSDELRDAVEDVILNRRDDSTERLLDLAEKYRDSKSGEVAIQQAEWRGWPVVKRL 667
Query: 1996 KFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFLPQVIK 2175
+++LVKG+ +F+ DTEEARQ RP+ VIE PLM GM VVG+LFG GKMFLPQV+K
Sbjct: 668 EYSLVKGITEFIELDTEEARQQA---DRPIEVIEGPLMSGMNVVGDLFGEGKMFLPQVVK 724
Query: 2176 SARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKNIVSVV 2355
SARVMK+AVA+L P++E +Q + G +++ATVKGDVHDIGKNIV VV
Sbjct: 725 SARVMKQAVAYLEPYIEASKQ-----------KGTTAGKILLATVKGDVHDIGKNIVGVV 773
Query: 2356 LGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRVGLNIP 2535
L CNN++++DLGVM P E I++ A EEK D IGLSGLITPSLDEMV VAKEM R G +P
Sbjct: 774 LQCNNYEIIDLGVMVPTEKILRTAREEKVDIIGLSGLITPSLDEMVNVAKEMERQGFTLP 833
Query: 2536 LLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLNEDYED 2715
LLIGGATTSK HTAVKI Y + +AS+SV V S+L + R+AF+ ++YE
Sbjct: 834 LLIGGATTSKAHTAVKIEQNYSGSTTYVSNASRSVGVVSALLSDTQREAFVAKTRKEYET 893
Query: 2716 VRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIPYIDWK 2895
VR +H L R IDW+ +T +G + + + L YIDW
Sbjct: 894 VRIQHARKKPRTPPVSLQAARNNPTVIDWENYTPPVAHKLGVQVVE-ASIETLRNYIDWT 952
Query: 2896 PFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAVVSFLP 3075
PFF W L GK YP+I +D VG EAK++ DA L KL E +L VV P
Sbjct: 953 PFFMTWSLAGK-----YPRILEDEVVGEEAKRLLADANALLDKLSAEDLLHPKGVVGLFP 1007
Query: 3076 AASEGDDMHVY-DPETGNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDDYLGLF 3252
A S GDD+ +Y D L Y LRQQ+ + D P++CL+D++ P +G DY G F
Sbjct: 1008 ANSVGDDIEIYRDERRDEVLAISYHLRQQT-EKTDFPNYCLADYVAPKSSG-KADYFGAF 1065
Query: 3253 ACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYSTNEDLT 3432
A T GL + + HDDY IM+KAL+DRLAEA+AEYLH+ VR WG++ NE+L+
Sbjct: 1066 AVTGGLEEDALADAYDAQHDDYNKIMIKALSDRLAEAFAEYLHERVRKVYWGFAPNENLS 1125
Query: 3433 ESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKN-GIGLTEHLAMLPAASVSGLY 3609
+L+ YQGIRPA GYP+ P+HTEK +W+LL+ E + G+ LTE AM P ASVSG Y
Sbjct: 1126 NEELVRENYQGIRPAPGYPACPEHTEKGQIWQLLDVETHTGMKLTESYAMWPGASVSGWY 1185
Query: 3610 FANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGYDTD 3747
F++P S+YFAV +I +DQV DYAARK +P EVERWL+P LGYD D
Sbjct: 1186 FSHPDSKYFAVAQIQRDQVEDYAARKGMPTAEVERWLAPNLGYDAD 1231
>gi|33603430|ref|NP_890990.1| 5-methyltetrahydrofolate--homocysteine
methyltransferase [Bordetella bronchiseptica RB50]
gi|33577554|emb|CAE34819.1| 5-methyltetrahydrofolate--homocysteine
methyltransferase [Bordetella bronchiseptica RB50]
Length = 1257
Score = 1218 bits (3152), Expect = 0.0
Identities = 656/1253 (52%), Positives = 859/1253 (68%), Gaps = 23/1253 (1%)
Frame = +1
Query: 46 ERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRPDIIYKIHKLYLE 225
+RI+I+DGAMGTMIQR + E DFRGE +H K LKG+N+LLS+ RPD+I +IH+ YLE
Sbjct: 25 KRILILDGAMGTMIQRYKLGEADFRGERFAEHHKDLKGDNELLSLVRPDVISEIHRQYLE 84
Query: 226 AGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAATGRRRYVCGAIG 405
AGAD +ETNTF T+IAQ DY L +E+N +SA +AR ACD R+V GA+G
Sbjct: 85 AGADVIETNTFGATSIAQGDYDLPELAYEMNLESARLARAACDAYSTPE-HPRFVAGALG 143
Query: 406 PTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVETVFDSANAKAALF 585
P +T SISP V P RNVTF EL AY +Q L+ GG+D++L+ET+FD+ NAKAA+F
Sbjct: 144 PQPKTASISPDVNDPGARNVTFDELRAAYVEQLNGLLDGGIDIVLIETIFDTLNAKAAIF 203
Query: 586 AIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKPMAVGLNCALGAKD 765
A+ FE GV +PV +SGT+ D SGR LSGQT EAF S + +P+ +GLNCALGA
Sbjct: 204 AVEETFEARGV-RLPVMISGTVTDASGRILSGQTVEAFWNSVRHARPVTIGLNCALGAAL 262
Query: 766 MRQFVDNMSKWSDSFIICYPNAGLPNALG--GYDETPEEMADVLREFARDGLVNIIGGCC 939
MR +V +SK D+++ YPNAGLPN + G+DETP + + +L EFA+ GLVN+ GGCC
Sbjct: 263 MRPYVAELSKICDTYVCVYPNAGLPNPMAETGFDETPADTSALLEEFAQAGLVNMAGGCC 322
Query: 940 GTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVNIGERCNVAGSR 1119
GTTP+HI A+ V +TPR P+ P K LSGLE + ET FVN+GER NV GS+
Sbjct: 323 GTTPEHIRAIAGKVASLTPRAVPEVPV--KTRLSGLEALNIDDETLFVNVGERTNVTGSK 380
Query: 1120 RFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLRLISSEPDVAKI 1299
F L++ E YD A+ VAR QV++GAQI+DVNMD+ +LD M +FL LI+SEPD+A++
Sbjct: 381 MFARLVREEKYDEALAVARQQVENGAQIIDVNMDEAMLDSVACMHRFLNLIASEPDIARV 440
Query: 1300 PVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGAAVVVMAFDEQG 1479
PV IDSS ++VI GL+ QGK VVNSIS+KEGEE F+ AR+ +RYGAA+VVMAFDEQG
Sbjct: 441 PVMIDSSKWEVIETGLKCVQGKAVVNSISMKEGEEPFRHHARLCRRYGAAMVVMAFDEQG 500
Query: 1480 QAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNYGMYFIEAARMI 1659
QA + + EIC R+YRIL EE GF P DIIFD N+ +ATG++EH++Y + FIE AR I
Sbjct: 501 QADSLERRKEICGRAYRILVEEEGFPPEDIIFDPNVFAVATGIDEHNHYAVDFIEGARWI 560
Query: 1660 RENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVNAGALPVYED-- 1833
R NLP A +SGG+SN+SFSFRG E +REA+H+VFL+YAI+AG+ MGIVNAG L VY D
Sbjct: 561 RANLPHARISGGISNVSFSFRGNEPMREAIHTVFLYYAIEAGLTMGIVNAGQLGVYADLA 620
Query: 1834 -----------IDKPXXXXXXXXXFNRDPEATEKLLVAAQEMXXXXXXXXXXXXEWRSLT 1980
+D+P R P TE+L+ A E WR+ +
Sbjct: 621 PHLRDLVEDVILDRPEPVGRSDSADERSP--TERLVQFA-ETVKGSGAKKEEDLTWRTGS 677
Query: 1981 VEERLKFALVKGVDQFVVADTEEARQN-TAKYPRPLNVIERPLMDGMAVVGELFGAGKMF 2157
VE+RL ALV G+ F+V DTEE RQ A+ R + VIE PLMDGM VVG+LFGAGKMF
Sbjct: 678 VEQRLAHALVHGITTFIVEDTEEVRQQVAARGGRTIEVIEGPLMDGMNVVGDLFGAGKMF 737
Query: 2158 LPQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGK 2337
LPQV+KSARVMK+AVAHL+PF+E E++ + A + +G +VIATVKGDVHDIGK
Sbjct: 738 LPQVVKSARVMKQAVAHLIPFIEEEKR----QIAAAGGDVRAKGKIVIATVKGDVHDIGK 793
Query: 2338 NIVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNR 2517
NIVSVVL CNNF+VV++GVM PC I++ A +E AD IGLSGLITPSL+EM YVA EM R
Sbjct: 794 NIVSVVLQCNNFEVVNMGVMVPCAQILQKAKDENADMIGLSGLITPSLEEMAYVASEMQR 853
Query: 2518 VGL----NIPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSL-SDMSVRDA 2682
+PL+IGGATTS+ HTAVKI+P Y PV++ DAS+SV V +SL SD + A
Sbjct: 854 DPYFRERAMPLMIGGATTSRVHTAVKIAPNYDGPVIYVPDASRSVGVATSLMSDQA--PA 911
Query: 2683 FLQDLNEDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFD 2862
+L +L ++YEDVR+ H A+ K L + R + +IDW + +P F+GRR ++++D
Sbjct: 912 YLAELAQEYEDVRRRH-ANRKAVPLVSLAEARAARPQIDWSGYQPPRPKFLGRRAFKSYD 970
Query: 2863 LNELIPYIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKI 3042
L E+ YIDW PFF W L G +P I DD VG +A+KV+++ Q LK++ID +
Sbjct: 971 LAEIARYIDWGPFFQTWSLFG-----PFPAILDDKVVGEQARKVYEEGQAMLKRIIDGRW 1025
Query: 3043 LVANAVVSFLPAASEGD-DMHVYDPETGNK-LDTFYGLRQQSGREHDQPHFCLSDFIKPL 3216
L A+ VV F PA D D+ VY ET ++ L T+ LRQQ + + CL+D+I P
Sbjct: 1026 LTASGVVGFYPANRVNDEDIEVYADETRSEVLFTYRNLRQQGVKREGVSNKCLADYIAPR 1085
Query: 3217 KNGVPDDYLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRT 3396
+G+ DY+G+FA TAGLG E+ + DDY+SIM+K+LADRLAEA+AE +H VR
Sbjct: 1086 DSGLL-DYIGMFAVTAGLGIEKKEAEFQAALDDYSSIMLKSLADRLAEAFAECMHARVRR 1144
Query: 3397 TLWGYSTNEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKNGIGLTEHLA 3576
LWGY+ +E L+ +L++ KY GIRPA GYP+ P+H K L+++L+A G+ LT+ A
Sbjct: 1145 DLWGYAADEALSNDELIAEKYSGIRPAPGYPACPEHVVKTDLFRVLDAADVGMELTDSYA 1204
Query: 3577 MLPAASVSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILG 3735
M PA+SVSG YF++P+S+YF VG I DQ+ DY AR +E+V R L+P LG
Sbjct: 1205 MFPASSVSGFYFSHPESQYFNVGNIGADQLADYVARSGRAEEDVRRTLAPNLG 1257
>gi|33594462|ref|NP_882106.1| 5-methyltetrahydrofolate--homocysteine
methyltransferase [Bordetella pertussis Tohama I]
gi|33564537|emb|CAE43853.1| 5-methyltetrahydrofolate--homocysteine
methyltransferase [Bordetella pertussis Tohama I]
Length = 1257
Score = 1217 bits (3148), Expect = 0.0
Identities = 656/1253 (52%), Positives = 859/1253 (68%), Gaps = 23/1253 (1%)
Frame = +1
Query: 46 ERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRPDIIYKIHKLYLE 225
+RI+I+DGAMGTMIQR + E DFRGE +H K LKG+N+LLS+ RPD+I +IH+ YLE
Sbjct: 25 KRILILDGAMGTMIQRYKLGEADFRGERFAEHHKDLKGDNELLSLVRPDVIAEIHRQYLE 84
Query: 226 AGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAATGRRRYVCGAIG 405
AGAD +ETNTF T+IAQ DY L +E+N +SA +AR ACD R+V GA+G
Sbjct: 85 AGADVIETNTFGATSIAQGDYDLPELAYEMNLESARLARAACDAYSTPE-HPRFVAGALG 143
Query: 406 PTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVETVFDSANAKAALF 585
P +T SISP V P RNVTF EL AY +Q L+ GG+D++L+ET+FD+ NAKAA+F
Sbjct: 144 PQPKTASISPDVNDPGARNVTFDELRAAYVEQLNGLLDGGIDIVLIETIFDTLNAKAAIF 203
Query: 586 AIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKPMAVGLNCALGAKD 765
A+ FE GV +PV +SGT+ D SGR LSGQT EAF S + +P+ +GLNCALGA
Sbjct: 204 AVEEAFEARGV-RLPVMISGTVTDASGRILSGQTVEAFWNSVRHARPVTIGLNCALGAAL 262
Query: 766 MRQFVDNMSKWSDSFIICYPNAGLPNALG--GYDETPEEMADVLREFARDGLVNIIGGCC 939
MR +V +SK D+++ YPNAGLPN + G+DETP + + +L EFA+ GLVN+ GGCC
Sbjct: 263 MRPYVAELSKICDTYVCVYPNAGLPNPMAETGFDETPADTSALLEEFAQAGLVNMAGGCC 322
Query: 940 GTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVNIGERCNVAGSR 1119
GTTP+HI A+ V +TPR P+ P K LSGLE + ET FVN+GER NV GS+
Sbjct: 323 GTTPEHIRAIAGKVAALTPRAVPEVPV--KTRLSGLEALNIDDETLFVNVGERTNVTGSK 380
Query: 1120 RFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLRLISSEPDVAKI 1299
F L++ E YD A+ VAR QV++GAQI+DVNMD+ +LD M +FL LI+SEPD+A++
Sbjct: 381 MFARLVREEKYDEALAVARQQVENGAQIIDVNMDEAMLDSVACMHRFLNLIASEPDIARV 440
Query: 1300 PVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGAAVVVMAFDEQG 1479
PV IDSS ++VI GL+ QGK VVNSIS+KEGEE F+ AR+ +RYGAA+VVMAFDEQG
Sbjct: 441 PVMIDSSKWEVIETGLKCVQGKAVVNSISMKEGEEPFRHHARLCRRYGAAMVVMAFDEQG 500
Query: 1480 QAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNYGMYFIEAARMI 1659
QA + + EIC R+YRIL EE GF P DIIFD N+ +ATG++EH++Y + FIE AR I
Sbjct: 501 QADSLERRKEICGRAYRILVEEEGFPPEDIIFDPNVFAVATGIDEHNHYAVDFIEGARWI 560
Query: 1660 RENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVNAGALPVYED-- 1833
R NLP A +SGG+SN+SFSFRG E +REA+H+VFL+YAI+AG+ MGIVNAG L VY D
Sbjct: 561 RANLPHARISGGISNVSFSFRGNEPMREAIHTVFLYYAIEAGLTMGIVNAGQLGVYADLA 620
Query: 1834 -----------IDKPXXXXXXXXXFNRDPEATEKLLVAAQEMXXXXXXXXXXXXEWRSLT 1980
+D+P R P TE+L+ A E WR+ +
Sbjct: 621 PHLRDLVEDVILDRPEPVGRSDSADERSP--TERLVQFA-ETVKGSGAKKEEDLTWRTGS 677
Query: 1981 VEERLKFALVKGVDQFVVADTEEARQN-TAKYPRPLNVIERPLMDGMAVVGELFGAGKMF 2157
VE+RL ALV G+ F+V DTEE RQ A+ R + VIE PLMDGM VVG+LFGAGKMF
Sbjct: 678 VEQRLAHALVHGITTFIVEDTEEVRQQVAARGGRTIEVIEGPLMDGMNVVGDLFGAGKMF 737
Query: 2158 LPQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGK 2337
LPQV+KSARVMK+AVAHL+PF+E E++ + A + +G +VIATVKGDVHDIGK
Sbjct: 738 LPQVVKSARVMKQAVAHLIPFIEEEKR----QIAAAGGDVRAKGKIVIATVKGDVHDIGK 793
Query: 2338 NIVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNR 2517
NIVSVVL CNNF+VV++GVM PC I++ A +E AD IGLSGLITPSL+EM YVA EM R
Sbjct: 794 NIVSVVLQCNNFEVVNMGVMVPCAQILQKAKDENADMIGLSGLITPSLEEMAYVASEMQR 853
Query: 2518 VGL----NIPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSL-SDMSVRDA 2682
+PL+IGGATTS+ HTAVKI+P Y PV++ DAS+SV V +SL SD + A
Sbjct: 854 DPYFRERAMPLMIGGATTSRVHTAVKIAPNYDGPVIYVPDASRSVGVATSLMSDQA--PA 911
Query: 2683 FLQDLNEDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFD 2862
+L +L ++YEDVR+ H A+ K L + R + +IDW + +P F+GRR ++++D
Sbjct: 912 YLAELAQEYEDVRRCH-ANRKAVPLVSLAEARAARPQIDWSGYQPPRPKFLGRRAFKSYD 970
Query: 2863 LNELIPYIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKI 3042
L E+ YIDW PFF W L G +P I DD VG +A+KV+++ Q LK++ID +
Sbjct: 971 LAEIARYIDWGPFFQTWSLFG-----PFPAILDDKVVGEQARKVYEEGQAMLKRIIDGRW 1025
Query: 3043 LVANAVVSFLPAASEGD-DMHVYDPETGNK-LDTFYGLRQQSGREHDQPHFCLSDFIKPL 3216
L A+ VV F PA D D+ VY ET ++ L T+ LRQQ + + CL+D+I P
Sbjct: 1026 LTASGVVGFYPANRVNDEDIEVYADETRSEMLFTYRNLRQQGVKREGVSNKCLADYIAPR 1085
Query: 3217 KNGVPDDYLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRT 3396
+G+ DY+G+FA TAGLG E+ + DDY+SIM+K+LADRLAEA+AE +H VR
Sbjct: 1086 DSGLL-DYIGMFAVTAGLGIEKKEAEFQAALDDYSSIMLKSLADRLAEAFAECMHARVRR 1144
Query: 3397 TLWGYSTNEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKNGIGLTEHLA 3576
LWGY+ +E L+ +L++ KY GIRPA GYP+ P+H K L+++L+A G+ LT+ A
Sbjct: 1145 DLWGYAADEALSNDELIAEKYSGIRPAPGYPACPEHVVKTDLFRVLDAADVGMELTDSYA 1204
Query: 3577 MLPAASVSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILG 3735
M PA+SVSG YF++P+S+YF VG I DQ+ DY AR +E+V R L+P LG
Sbjct: 1205 MFPASSVSGFYFSHPESQYFNVGNIGADQLADYVARSGRAEEDVRRTLAPNLG 1257
>gi|33598486|ref|NP_886129.1| 5-methyltetrahydrofolate--homocysteine
methyltransferase [Bordetella parapertussis 12822]
gi|33574615|emb|CAE39266.1| 5-methyltetrahydrofolate--homocysteine
methyltransferase [Bordetella parapertussis]
Length = 1257
Score = 1215 bits (3144), Expect = 0.0
Identities = 655/1253 (52%), Positives = 858/1253 (68%), Gaps = 23/1253 (1%)
Frame = +1
Query: 46 ERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRPDIIYKIHKLYLE 225
+RI+I+DGAMGTMIQR + E DFRGE +H K LKG+N+LLS+ RPD+I +IH+ YLE
Sbjct: 25 KRILILDGAMGTMIQRYKLGEADFRGERFAEHHKDLKGDNELLSLVRPDVISEIHRQYLE 84
Query: 226 AGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAATGRRRYVCGAIG 405
AGAD +ETNTF T+IAQ DY L +E+N +SA +AR ACD R+V GA+G
Sbjct: 85 AGADVIETNTFGATSIAQGDYDLPELAYEMNLESARLARAACDAYSTPE-HPRFVAGALG 143
Query: 406 PTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVETVFDSANAKAALF 585
P +T SISP V P RNVTF EL AY +Q L+ GG+D++L+ET+FD+ NAKAA+F
Sbjct: 144 PQPKTASISPDVNDPGARNVTFDELRAAYVEQLNGLLDGGIDIVLIETIFDTLNAKAAIF 203
Query: 586 AIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKPMAVGLNCALGAKD 765
A+ FE GV +PV +SGT+ D SGR LSGQT EAF S + +P+ +GLNCALGA
Sbjct: 204 AVEETFEARGV-RLPVMISGTVTDASGRILSGQTVEAFWNSVRHARPVTIGLNCALGAAL 262
Query: 766 MRQFVDNMSKWSDSFIICYPNAGLPNALG--GYDETPEEMADVLREFARDGLVNIIGGCC 939
MR +V +SK D+++ YPNAGLPN + G+DETP + + +L EFA+ GLVN+ GGCC
Sbjct: 263 MRPYVAELSKICDTYVCVYPNAGLPNPMAETGFDETPADTSALLEEFAQAGLVNMAGGCC 322
Query: 940 GTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVNIGERCNVAGSR 1119
GTTP+HI A+ V +TPR P+ P K LSGLE + ET FVN+GER NV GS+
Sbjct: 323 GTTPEHIRAIAGKVASLTPRAVPEVPV--KTRLSGLEALNIDDETLFVNVGERTNVTGSK 380
Query: 1120 RFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLRLISSEPDVAKI 1299
F L++ E YD A+ VAR QV++GAQI+DVNMD+ +LD M +FL LI+SEPD+A++
Sbjct: 381 MFARLVREEKYDEALAVARQQVENGAQIIDVNMDEAMLDSVACMHRFLNLIASEPDIARV 440
Query: 1300 PVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGAAVVVMAFDEQG 1479
PV IDSS ++VI GL+ QGK VVNSIS+KEGEE F+ AR+ +RYGAA+VVMAFDEQG
Sbjct: 441 PVMIDSSKWEVIETGLKCVQGKAVVNSISMKEGEEPFRHHARLCRRYGAAMVVMAFDEQG 500
Query: 1480 QAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNYGMYFIEAARMI 1659
QA + + EIC R+YRIL EE GF P DIIFD N+ +ATG++EH++Y + FIE AR I
Sbjct: 501 QADSLERRKEICGRAYRILVEEEGFPPEDIIFDPNVFAVATGIDEHNHYAVDFIEGARWI 560
Query: 1660 RENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVNAGALPVYED-- 1833
R NLP A +SGG+SN+SFSFRG E +REA+H+VFL+YAI+AG+ MGIVNAG L VY D
Sbjct: 561 RANLPHARISGGISNVSFSFRGNEPMREAIHTVFLYYAIEAGLTMGIVNAGQLGVYADLA 620
Query: 1834 -----------IDKPXXXXXXXXXFNRDPEATEKLLVAAQEMXXXXXXXXXXXXEWRSLT 1980
+D+P R P TE+L+ A E WR+ +
Sbjct: 621 PHLRDLVEDVILDRPEPVGRSDSADERSP--TERLVQFA-ETVKGSGAKKEEDLTWRTGS 677
Query: 1981 VEERLKFALVKGVDQFVVADTEEARQN-TAKYPRPLNVIERPLMDGMAVVGELFGAGKMF 2157
VE+RL ALV G+ F+V DTEE RQ A+ R + VIE PLMDGM VVG+LFGAGKMF
Sbjct: 678 VEQRLAHALVHGITTFIVEDTEEVRQQVAARGGRTIEVIEGPLMDGMNVVGDLFGAGKMF 737
Query: 2158 LPQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGK 2337
LPQV+KSARVMK+AVAHL+PF+E E++ + A + +G +VIATVKGDVHDIGK
Sbjct: 738 LPQVVKSARVMKQAVAHLIPFIEEEKR----QIAAAGGDVRAKGKIVIATVKGDVHDIGK 793
Query: 2338 NIVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNR 2517
NIVSVVL CNNF+VV++GVM PC I++ A +E AD IGLSGLITPSL+EM YVA EM R
Sbjct: 794 NIVSVVLQCNNFEVVNMGVMVPCAQILQKAKDENADMIGLSGLITPSLEEMAYVASEMQR 853
Query: 2518 VGL----NIPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSL-SDMSVRDA 2682
+PL+IGGATTS+ HTAVKI+P Y V++ DAS+SV V +SL SD + A
Sbjct: 854 DPYFRERAMPLMIGGATTSRVHTAVKIAPNYDGSVIYVPDASRSVGVATSLMSDQA--PA 911
Query: 2683 FLQDLNEDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFD 2862
+L +L ++YEDVR+ H A+ K L + R + +IDW + +P F+GRR ++++D
Sbjct: 912 YLAELAQEYEDVRRRH-ANRKAVPLVSLAEARAARPQIDWSGYQPPRPKFLGRRAFKSYD 970
Query: 2863 LNELIPYIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKI 3042
L E+ YIDW PFF W L G +P I DD VG +A+KV+++ Q LK++ID +
Sbjct: 971 LAEIARYIDWGPFFQTWSLFG-----PFPAILDDKVVGEQARKVYEEGQAMLKRIIDGRW 1025
Query: 3043 LVANAVVSFLPAASEGD-DMHVYDPETGNK-LDTFYGLRQQSGREHDQPHFCLSDFIKPL 3216
L A+ VV F PA D D+ VY ET ++ L T+ LRQQ + + CL+D+I P
Sbjct: 1026 LTASGVVGFYPANRVNDEDIEVYADETRSEVLFTYRNLRQQGVKREGVSNKCLADYIAPR 1085
Query: 3217 KNGVPDDYLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRT 3396
+G+ DY+G+FA TAGLG E+ + DDY+SIM+K+LADRLAEA+AE +H VR
Sbjct: 1086 DSGLL-DYIGMFAVTAGLGIEKKEAEFQAALDDYSSIMLKSLADRLAEAFAECMHARVRR 1144
Query: 3397 TLWGYSTNEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKNGIGLTEHLA 3576
LWGY+ +E L+ +L++ KY GIRPA GYP+ P+H K L+++L+A G+ LT+ A
Sbjct: 1145 DLWGYAADEALSNDELIAEKYSGIRPAPGYPACPEHVVKTDLFRVLDAADVGMELTDSYA 1204
Query: 3577 MLPAASVSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILG 3735
M PA+SVSG YF++P+S+YF VG I DQ+ DY AR +E+V R L+P LG
Sbjct: 1205 MFPASSVSGFYFSHPESQYFNVGNIGADQLADYVARSGRAEEDVRRTLAPNLG 1257
>gi|30249588|ref|NP_841658.1| metH Methionine synthase I,
cobalamin-binding domain [Nitrosomonas europaea ATCC
19718]
gi|30138951|emb|CAD85534.1| metH Methionine synthase I,
cobalamin-binding domain [Nitrosomonas europaea ATCC
19718]
Length = 1237
Score = 1209 bits (3129), Expect = 0.0
Identities = 642/1257 (51%), Positives = 840/1257 (66%), Gaps = 10/1257 (0%)
Frame = +1
Query: 1 MTRSSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSI 180
MT + L + ERI+++DGAMGTMIQ + E D+RGE D LKGNNDLL +
Sbjct: 1 MTMHERADLLKRLLAERILMLDGAMGTMIQSYKLTESDYRGERFADFPHDLKGNNDLLCL 60
Query: 181 TRPDIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDV 360
TRP++I IH+ YLEAG+D +ETNTF+ + ADY + LV+E+N A R AC++
Sbjct: 61 TRPEVIRSIHRAYLEAGSDIIETNTFNSNAPSMADYHMQDLVYELNVAGA---RLACEEA 117
Query: 361 GAAT----GRRRYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGV 528
A R R+V G IGPT +T S+SP V P FR +TF +LV++Y + R LI GG
Sbjct: 118 RAMETQQPDRPRFVAGVIGPTTKTASLSPDVNDPGFRAITFDDLVESYTESVRGLIDGGA 177
Query: 529 DVLLVETVFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVS 708
D+LLVET+FD+ NAKAALFAI FE G+ +PV +S TI D SGR LSGQT EAF S
Sbjct: 178 DILLVETIFDTLNAKAALFAIDQYFETHGL-RLPVMISVTITDASGRNLSGQTPEAFWNS 236
Query: 709 TKQGKPMAVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALG--GYDETPEEMA 882
+ +P++VG+NCALGA+ MR +V+ +S ++ F +PNAGLPN L GYDETPE A
Sbjct: 237 VRHARPLSVGINCALGAELMRPYVEELSNVAEVFTSAHPNAGLPNPLAETGYDETPEYTA 296
Query: 883 DVLREFARDGLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIV 1062
++++FA+ G VNI+GGCCGTTP HI A+ +AV+ I PR P P K+ LSGLEP +
Sbjct: 297 RLIKDFAQSGFVNIVGGCCGTTPKHIAAIAEAVRDIPPRPLPDIPK--KLRLSGLEPLNI 354
Query: 1063 GPETNFVNIGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGP 1242
+ FVN+GER NV GS+ F LI N Y + +AR QV++GAQI+D+NMD+ +LD
Sbjct: 355 DEHSLFVNVGERTNVTGSKAFARLILNGGYAEGLVIARSQVENGAQIIDINMDEAMLDSQ 414
Query: 1243 YAMSKFLRLISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERA 1422
AM FL L+++EPD++++P+ +DSS + VI AGL+ QGK V+NSISLKEGE +F A
Sbjct: 415 KAMVTFLNLLAAEPDISRLPIMLDSSKWSVIEAGLKCVQGKAVINSISLKEGEAEFLHHA 474
Query: 1423 RIIKRYGAAVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIAT 1602
R+ +RYGAAV+VMAFDE GQA K EIC R Y L E+ F P DIIFD NI IAT
Sbjct: 475 RLARRYGAAVIVMAFDETGQADTLQRKVEICTRCYHTLIEQADFPPEDIIFDPNIFAIAT 534
Query: 1603 GMEEHSNYGMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKA 1782
G+EEHSNY + FIEA +IR+ LP A VSGGVSN+SFSFRG E IREA+H+ FL++A+KA
Sbjct: 535 GIEEHSNYAVDFIEATHVIRQTLPYAKVSGGVSNVSFSFRGNEPIREAIHTAFLYHAVKA 594
Query: 1783 GMDMGIVNAGALPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEMXXXXXXXXXXXX 1962
GM MGIVNAG L VY DI NR P+ATE+L+ A E
Sbjct: 595 GMTMGIVNAGQLGVYSDIPPDLLEHVEDVLLNRRPDATERLVEFA-EHFKGQKKEQIEDL 653
Query: 1963 EWRSLTVEERLKFALVKGVDQFVVADTEEARQN-TAKYPRPLNVIERPLMDGMAVVGELF 2139
WR V +RL ALV+G+ ++V DTE RQ ++ +P+ VIE PLMDGM VVG+LF
Sbjct: 654 SWRDEPVRQRLIHALVRGISTYIVEDTELVRQEIDSQGGKPIEVIEGPLMDGMNVVGDLF 713
Query: 2140 GAGKMFLPQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGD 2319
GAGKMFLPQV+KSARVMK+AVA+LLP++E E++ ++ D P +G VVIATVKGD
Sbjct: 714 GAGKMFLPQVVKSARVMKQAVAYLLPYIEAEKK-------ISGDSKP-KGKVVIATVKGD 765
Query: 2320 VHDIGKNIVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYV 2499
VHDIGKNIVSVVL CNNF+V+++GVM P I++ A E+ D IGLSGLITPSL+EM +V
Sbjct: 766 VHDIGKNIVSVVLQCNNFEVINMGVMVPSAQILETARREQVDMIGLSGLITPSLEEMAHV 825
Query: 2500 AKEMNRVGLNIPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRD 2679
A+EM R +PLLIGGATTS+ HTAVKI+P Y V DAS++V VCS+L +RD
Sbjct: 826 AREMEREQFTVPLLIGGATTSRMHTAVKIAPHYGGVTVWVPDASRAVGVCSNLMSQDLRD 885
Query: 2680 AFLQDLNEDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNF 2859
+++ + + E R +H + + R K DW ++T P F+G R N+
Sbjct: 886 DYVRQVKAEQEKSRVQHRNKKGPSKLLTFEEARANALKTDWARYTPPAPDFLGLRTLNNY 945
Query: 2860 DLNELIPYIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEK 3039
L L+P+IDW PFF W+L G+ YP I D VG A +F DAQ L+K++++K
Sbjct: 946 PLETLVPHIDWTPFFQAWELHGR-----YPAILQDELVGEAASNLFRDAQNMLRKIVEQK 1000
Query: 3040 ILVANAVVSFLPAAS-EGDDMHVY-DPETGNKLDTFYGLRQQSGREHDQPHFCLSDFIKP 3213
L ANAV+ PA + GDD+ +Y D + T++ LRQQ+ + +P+ L+DFI P
Sbjct: 1001 WLTANAVIGLFPANTVNGDDIEIYADRSRSQVIMTWHTLRQQTAKPAGRPNLALADFIAP 1060
Query: 3214 LKNGVPDDYLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVR 3393
+ G+ DD +GLFA +AG G +E + E +DDY++I++KALADRLAEA+AE++H VR
Sbjct: 1061 RETGL-DDTIGLFAVSAGFGIDERIRAFEAANDDYSAIILKALADRLAEAFAEHMHARVR 1119
Query: 3394 TTLWGYSTNEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEK-NGIGLTEH 3570
WGY +E L L+ +Y GIRPA GYP+ PDHTEK L+ LLEAEK +GI +TE
Sbjct: 1120 REFWGYVKDESLDNEQLIDEQYLGIRPAPGYPACPDHTEKGPLFALLEAEKRSGIVITES 1179
Query: 3571 LAMLPAASVSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGYD 3741
AM+P A+VSG Y + P+S YFAVGKI +DQV DYA RK EE ERWL+P+L Y+
Sbjct: 1180 FAMVPTAAVSGFYLSYPESSYFAVGKIGKDQVEDYARRKGWTLEEAERWLAPVLAYE 1236
>gi|581135|emb|CAA34601.1| unnamed protein product [Escherichia coli]
Length = 1200
Score = 1202 bits (3110), Expect = 0.0
Identities = 639/1218 (52%), Positives = 825/1218 (67%), Gaps = 5/1218 (0%)
Frame = +1
Query: 10 SSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRP 189
SS E+L ERI+++DG MGTMIQ + E DFRGE D LKGNNDLL +++P
Sbjct: 2 SSKVEQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSKP 61
Query: 190 DIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAA 369
++I IH Y EAGAD +ETNTF+ TTIA ADY+ E L EIN+ +A +ARR D+ A
Sbjct: 62 EVIAAIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARRCADEWTAR 121
Query: 370 TGRR-RYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVE 546
T + RYV G +GPTNRT SISP V P FRN+TF LV AY + ++L++GG D++L+E
Sbjct: 122 TPEKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDGLVAAYRESTKALVEGGADLILIE 181
Query: 547 TVFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKP 726
TVFD+ NAKAA+FA++T FE GV E+P+ +SGTI D SGRTLSGQT EAF S + +
Sbjct: 182 TVFDTLNAKAAVFAVKTEFEALGV-ELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEA 240
Query: 727 MAVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFAR 906
+ GLNCALG ++RQ+V +S+ ++ ++ +PNAGLPNA G YD + MA +RE+A+
Sbjct: 241 LTFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAQ 300
Query: 907 DGLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVN 1086
G +NI+GGCCGTTP HI AM +AV+G+ PR P+ P A + LSGLEP +G ++ FVN
Sbjct: 301 AGFLNIVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACR--LSGLEPLNIGEDSLFVN 358
Query: 1087 IGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLR 1266
+GER NV GS +F LIK E Y A+DVAR QV++GAQI+D+NMD+G+LD AM +FL
Sbjct: 359 VGERTNVTGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLN 418
Query: 1267 LISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGA 1446
LI+ EPD+A++P+ IDSS +DVI GL+ QGK +VNSIS+KEG + F A++++RYGA
Sbjct: 419 LIAGEPDIARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGA 478
Query: 1447 AVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNY 1626
AVVVMAFDEQGQA K EIC R+Y+ILTEEVGF P DIIFD NI +ATG+EEH+NY
Sbjct: 479 AVVVMAFDEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNY 538
Query: 1627 GMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVN 1806
FI A I+ LP A +SGGVSN+SFSFRG + +REA+H+VFL+YAI+ GMDMGIVN
Sbjct: 539 AQDFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVN 598
Query: 1807 AGALPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEM--XXXXXXXXXXXXEWRSLT 1980
AG L +Y+D+ NR + TE+LL A++ EWRS
Sbjct: 599 AGQLAIYDDLPAELRDAVEDVILNRRDDGTERLLELAEKYRGTKTDDTANAQQAEWRSWE 658
Query: 1981 VEERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFL 2160
V +RL+++LVKG+ +F+ DTEEARQ RP+ VIE PLMDGM VVG+LFG GKMFL
Sbjct: 659 VNKRLEYSLVKGITEFIEQDTEEARQQAT---RPIEVIEGPLMDGMNVVGDLFGEGKMFL 715
Query: 2161 PQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKN 2340
PQV+KSARVMK+AVA+L PF+E ++++ G +VIATVKGDVHDIGKN
Sbjct: 716 PQVVKSARVMKQAVAYLEPFIE-----------ASKEQGKTNGKMVIATVKGDVHDIGKN 764
Query: 2341 IVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRV 2520
IV VVL CNN+++VDLGVM P E I++ A E AD IGLSGLITPSLDEMV VAKEM R
Sbjct: 765 IVGVVLQCNNYEIVDLGVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQ 824
Query: 2521 GLNIPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLN 2700
G IPLLIGGATTSK HTAVKI Y P V+ +AS++V V ++L + RD F+
Sbjct: 825 GFTIPLLIGGATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTR 884
Query: 2701 EDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIP 2880
++YE VR +H L R+ F DW +T +G +E + + L
Sbjct: 885 KEYETVRIQHGRKKPRTPPVTLEAARDNDFAFDWQAYTPPVAHRLGVQEVE-ASIETLRN 943
Query: 2881 YIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAV 3060
YIDW PFF W L GK YP+I +D VG EA+++F DA L KL EK L V
Sbjct: 944 YIDWTPFFMTWSLAGK-----YPRILEDEVVGVEAQRLFKDANDMLDKLSAEKTLNPRGV 998
Query: 3061 VSFLPAASEGDDMHVYDPET-GNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDD 3237
V PA GDD+ +Y ET + ++ + LRQQ+ + ++CL+DF+ P +G D
Sbjct: 999 VGLFPANRVGDDIEIYRDETRTHVINVSHHLRQQT-EKTGFANYCLADFVAPKLSG-KAD 1056
Query: 3238 YLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYST 3417
Y+G FA T GL + E + DDY IMVKALADRLAEA+AEYLH+ VR WGY+
Sbjct: 1057 YIGAFAVTGGLEEDALADAFEAHDDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAP 1116
Query: 3418 NEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKN-GIGLTEHLAMLPAAS 3594
NE+L+ +L+ YQGIRPA GYP+ P+HTEK T+W+LLE EK+ G+ LTE AM P AS
Sbjct: 1117 NENLSNEELIRENYQGIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGAS 1176
Query: 3595 VSGLYFANPQSEYFAVGK 3648
VSG YF++P S+Y+AV +
Sbjct: 1177 VSGWYFSHPDSKYYAVAQ 1194
>gi|50084246|ref|YP_045756.1| methionine synthase (B12-dependent
homocysteine-N5-methyltetrahydrofolate transmethylase,
repressor of metE and metF) [Acinetobacter sp. ADP1]
gi|49530222|emb|CAG67934.1| methionine synthase (B12-dependent
homocysteine-N5-methyltetrahydrofolate transmethylase,
repressor of metE and metF) [Acinetobacter sp. ADP1]
Length = 1228
Score = 1197 bits (3096), Expect = 0.0
Identities = 640/1249 (51%), Positives = 843/1249 (67%), Gaps = 9/1249 (0%)
Frame = +1
Query: 13 SLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRPD 192
S L + ERI+IIDGAMGTMIQR +EE+D+RGE D LKGNNDLL +T+P
Sbjct: 2 STLTTLKALLAERILIIDGAMGTMIQRHKLEEDDYRGERFADWASDLKGNNDLLVLTQPQ 61
Query: 193 IIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAAT 372
II IH+ YL+AGAD +ETN+F+GT ++ +DY E LV EIN ++A +AR ACD +
Sbjct: 62 IIQGIHEAYLDAGADIIETNSFNGTRVSMSDYHMEDLVPEINREAARLARAACDKY-STP 120
Query: 373 GRRRYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVETV 552
+ R+V G +GPT+RT SISP+V P FRN+TF EL + Y + +LI+GG D+LL+ETV
Sbjct: 121 DKPRFVAGVLGPTSRTCSISPNVNDPAFRNITFDELKENYIEATHALIEGGADILLIETV 180
Query: 553 FDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKPMA 732
FD+ N KAA+FA++ +F+ G E+P+ +SGTI D SGRTL+GQT EAF S + G ++
Sbjct: 181 FDTLNCKAAIFAVKEVFKQLG-HELPLMISGTITDASGRTLTGQTAEAFWNSVRHGDLLS 239
Query: 733 VGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFARDG 912
+G NCALGA MR V +S +D+F+ +PNAGLPNA G YDETPE+ A L+EFA G
Sbjct: 240 IGFNCALGADAMRPHVKTISDVADTFVSAHPNAGLPNAFGEYDETPEQTAAFLKEFAMSG 299
Query: 913 LVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVNIG 1092
L+NI GGCCGTTPDHI A+Y AV+ I PR P+ A + LSGLEP + ++ FVN+G
Sbjct: 300 LINITGGCCGTTPDHIRAIYNAVKDIQPRQIPETKPACR--LSGLEPFNIYDDSLFVNVG 357
Query: 1093 ERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLRLI 1272
ER NV GS++F LI+ E + A++VA+ QV++GAQI+D+NMD+G+LD AM FL L+
Sbjct: 358 ERTNVTGSKKFLRLIREEKFAEALEVAQQQVEAGAQIIDINMDEGMLDSQNAMVHFLNLV 417
Query: 1273 SSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGAAV 1452
+SEPD++++P+ IDSS +++I AGL+ QGK VVNSISLKEG ++F E+AR+ ++YGAA+
Sbjct: 418 ASEPDISRVPIMIDSSKWEIIEAGLKCVQGKPVVNSISLKEGYDEFVEKARLCRQYGAAI 477
Query: 1453 VVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNYGM 1632
+VMAFDE GQA K EIC+RSY +L EVGF DIIFD N+ +ATG+EEH+NYG+
Sbjct: 478 IVMAFDETGQADTAARKREICKRSYDVLVNEVGFPAEDIIFDPNVFAVATGIEEHNNYGV 537
Query: 1633 YFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVNAG 1812
FIEA I++NLP A +SGGVSN+SFSFRG E +REA+HSVFL++AIK GM MGIVNAG
Sbjct: 538 DFIEATGWIKQNLPHAMISGGVSNVSFSFRGNEPVREAIHSVFLYHAIKQGMTMGIVNAG 597
Query: 1813 ALPVYEDIDKPXXXXXXXXXFNRD-----PEATEKLLVAAQEM-XXXXXXXXXXXXEWRS 1974
+ +Y+DI K N++ ATEKLL A++ EWR+
Sbjct: 598 QMAIYDDIPKELKDAVEDVVLNQNQGESGQNATEKLLEVAEKFRGHSGAQREAENLEWRN 657
Query: 1975 LTVEERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKM 2154
+VE+RL++ALVKG+ ++ DTEEAR K RPL+VIE LMDGM VVG+LFG+GKM
Sbjct: 658 ESVEKRLEYALVKGITTYIDEDTEEAR---LKAKRPLDVIEGALMDGMNVVGDLFGSGKM 714
Query: 2155 FLPQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIG 2334
FLPQV+KSARVMK+AVA L P++E E+ S +G V++ATVKGDVHDIG
Sbjct: 715 FLPQVVKSARVMKQAVAWLNPYIEAEKTG-----------SQSKGKVLMATVKGDVHDIG 763
Query: 2335 KNIVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMN 2514
KNIV VVLGCN + +VDLGVM P E I++ AI+EK D IGLSGLITPSLDEMV+VAKEM
Sbjct: 764 KNIVGVVLGCNGYDIVDLGVMVPAEKILQTAIDEKCDIIGLSGLITPSLDEMVFVAKEMQ 823
Query: 2515 RVGLNIPLLIGGATTSKTHTAVKISPRYPH-PVVHCLDASKSVVVCSSLSDMSVRDAFLQ 2691
R G NIPLLIGGATTSK HTAVKI P+Y + V++ DAS++V V ++L +R F+
Sbjct: 824 RKGFNIPLLIGGATTSKAHTAVKIDPQYQNDAVIYVADASRAVGVATTLLSKEMRGNFIA 883
Query: 2692 DLNEDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNE 2871
+ +Y +R+ + + F IDW+ + KP+ +G + N+ L +
Sbjct: 884 EHRAEYAKIRERLANKQPKAAKLSYQEAVKNGFNIDWNAYVPPKPNLLGEQVITNYPLEK 943
Query: 2872 LIPYIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVA 3051
L+PY DW PFF W L GK +PKI D VG A +++ AQ LK +I+ K A
Sbjct: 944 LVPYFDWTPFFISWSLTGK-----FPKILTDEIVGEAATDLYNQAQAMLKDIIENKRFDA 998
Query: 3052 NAVVSFLPAASEGDD-MHVYDPETGNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGV 3228
AV + PA GDD + VYD + GN TF LRQQS + +P+ L+DFI +
Sbjct: 999 RAVFALYPAKRTGDDTVSVYDMQ-GNITHTFEHLRQQSDKVTGKPNLSLADFISTSQEHT 1057
Query: 3229 PDDYLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWG 3408
DYLG F + GAEE + DDY++I+V++L DR AEA+AE+LH+ +R WG
Sbjct: 1058 --DYLGGFTVSI-FGAEELANEYKAKGDDYSAILVQSLGDRFAEAFAEHLHELIRKDYWG 1114
Query: 3409 YSTNEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLL-EAEKNGIGLTEHLAMLP 3585
Y +E L L+ KY GIRPA GYP+ P+H+EK L+ L +K G LT AM P
Sbjct: 1115 YQPDEALDNEALIKEKYVGIRPAPGYPACPEHSEKAVLFDWLGSTDKIGTFLTSSFAMWP 1174
Query: 3586 AASVSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPIL 3732
+SVSG Y++ PQSEYF VGKI QDQ+ DYA RK +E +RWL+P L
Sbjct: 1175 PSSVSGFYYSLPQSEYFNVGKISQDQLEDYAKRKGWTMDEAKRWLAPNL 1223
>gi|46141011|ref|ZP_00152801.2| COG1410: Methionine synthase I,
cobalamin-binding domain [Dechloromonas aromatica RCB]
Length = 1220
Score = 1196 bits (3093), Expect = 0.0
Identities = 640/1241 (51%), Positives = 853/1241 (68%), Gaps = 5/1241 (0%)
Frame = +1
Query: 25 ELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRPDIIYK 204
EL+ + ++R++++DGAMGTMIQR ++E D+RGE KDH LKGNNDLL +TRPDII
Sbjct: 8 ELSSLLQQRLLVLDGAMGTMIQRHGLQEADYRGERFKDHPHDLKGNNDLLVLTRPDIIGG 67
Query: 205 IHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAAT-GRR 381
IH+ YLEAGAD +ET TF+ T ++QADY LV+E+N++ A +AR+ CD+ AA +
Sbjct: 68 IHREYLEAGADILETCTFNSTAVSQADYNLSELVYELNFEGAKLARQLCDEFTAANPAKP 127
Query: 382 RYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVETVFDS 561
R+V G +GPT+RT SISP V P +RNVTF ELV Y + L++GG D+LLVETVFD+
Sbjct: 128 RFVAGVLGPTSRTASISPDVNDPGYRNVTFDELVANYVEAITGLVEGGADILLVETVFDT 187
Query: 562 ANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKPMAVGL 741
NAKAALFAI F D PV +SGTI D SGRTLSGQT EAF S + +P++ GL
Sbjct: 188 LNAKAALFAIEKFF-DIAQRRWPVMISGTITDASGRTLSGQTAEAFWNSLRHVQPVSFGL 246
Query: 742 NCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFARDGLVN 921
NCALGAK++RQ+V+ +S+ D ++ +PNAGLPNA GGYDET + +AD + +A+ G+VN
Sbjct: 247 NCALGAKELRQYVEELSRVCDCYVSAHPNAGLPNAFGGYDETADMLADEIESWAKAGIVN 306
Query: 922 IIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVNIGERC 1101
I+GGCCGT+P+HI A+ + V ++PR P A + LSGLE V P + +VN+GER
Sbjct: 307 IVGGCCGTSPEHIAAIAQRVATVSPRQRPAIEPA--LRLSGLEAFNVTPGSLYVNVGERT 364
Query: 1102 NVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLRLISSE 1281
NV GS+ F +I +D A+ VAR QV++GAQI+D+NMD+ +LD AM KFL+LI+SE
Sbjct: 365 NVTGSKAFARMILEGRFDDALAVARQQVENGAQIIDINMDEAMLDSLAAMDKFLKLIASE 424
Query: 1282 PDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGAAVVVM 1461
PD++++P+ IDSS ++VI AGL+ QGK +VNSIS+KEGE KF E+A++ +RYGAAV+VM
Sbjct: 425 PDISRVPIMIDSSKWEVIEAGLKCIQGKGIVNSISMKEGEAKFIEQAKLARRYGAAVIVM 484
Query: 1462 AFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNYGMYFI 1641
AFDE+GQA K EI +R+Y +L +GF DIIFD NI IATG+ EH NY + FI
Sbjct: 485 AFDEKGQADTFARKTEISKRAYDLLL-SIGFPAEDIIFDPNIFAIATGIPEHDNYAVDFI 543
Query: 1642 EAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVNAGALP 1821
E+ R I++NLP AH+SGGVSN+SFSFRG + +REA+H+VFL++AIK GM MGIVNAG L
Sbjct: 544 ESVRWIKQNLPHAHISGGVSNVSFSFRGNDPVREAIHTVFLYHAIKNGMTMGIVNAGMLG 603
Query: 1822 VYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEMXXXXXXXXXXXXEWRSLTVEERLKF 2001
+Y+D++ NR+P A E L+ AQ + WR +VE+RL+
Sbjct: 604 IYDDLEPELRQKVEDVVLNRNPNAGEALVDFAQTVKEGKAKDTGPDLSWREQSVEKRLEH 663
Query: 2002 ALVKGVDQFVVADTEEAR-QNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFLPQVIKS 2178
AL+KG+ FVVADTEE R Q A+ PL VIE PLM GM VG+LFGAGKMFLPQV+KS
Sbjct: 664 ALIKGITDFVVADTEEVRAQLEAEGKPPLAVIEGPLMAGMNHVGDLFGAGKMFLPQVVKS 723
Query: 2179 ARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKNIVSVVL 2358
ARVMK+AVAHLLP++E E+ GL +G +++ATVKGDVHDIGKNIV VVL
Sbjct: 724 ARVMKQAVAHLLPYIEAEKTRT----GLGS-----KGKILMATVKGDVHDIGKNIVGVVL 774
Query: 2359 GCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRVGLNIPL 2538
GCN + V+DLGVM C+NI+KAA+E + D IGLSGLITPSL+EM +VA EM R G+ PL
Sbjct: 775 GCNGYDVIDLGVMVSCDNILKAALEHRVDIIGLSGLITPSLEEMAHVASEMQRQGMKQPL 834
Query: 2539 LIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLNEDYEDV 2718
LIGGATTS+ HTA+KI+P VV+ DAS++V V + L RD ++ ++ +YE V
Sbjct: 835 LIGGATTSRAHTAIKIAPNTEGAVVYVPDASRAVGVATKLLSTEQRDGYMAEIVAEYEAV 894
Query: 2719 RQEHYASLKDRRFTDLNKTREKKFKIDWDK-FTAVKPSFVGRREYQNFDLNELIPYIDWK 2895
R EH + K L + R +F W++ FT KP +G + N L++L IDW
Sbjct: 895 RAEH-SGRKGATMVTLAEARANRF--TWNEPFTPAKPKQLGLQTL-NPSLSDLALLIDWT 950
Query: 2896 PFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAVVSFLP 3075
PFF W L G+ YP I D+ VG A+++F DA+ L K+I E L A AV P
Sbjct: 951 PFFQSWDLAGR-----YPAILDNETVGETARQLFTDAKEMLGKIISENWLSARAVFGLYP 1005
Query: 3076 AASEGDDMHVYDPET-GNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDDYLGLF 3252
A +E +D+ +Y E+ +L + GLRQQ + + + L+DFI +DY+G F
Sbjct: 1006 AKAENEDIIIYSDESRTTELTRWVGLRQQHKQPKGRFNMALADFIG------ENDYVGAF 1059
Query: 3253 ACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYSTNEDLT 3432
A TAG EE E HDDY++IM+K+LADRLAEA AE+LH +VRT WGY+ +E T
Sbjct: 1060 AVTAGHRIEERVAAFEAAHDDYSAIMLKSLADRLAEAAAEWLHLQVRTQYWGYAHDETFT 1119
Query: 3433 ESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKN-GIGLTEHLAMLPAASVSGLY 3609
++L++ +Y+GIRPA GYP+ PDHT KR L+ LL+A N G+ LTE AM PAA+VSG Y
Sbjct: 1120 NAELIAEQYKGIRPAPGYPACPDHTAKRELFALLDAPANAGMQLTESCAMTPAAAVSGFY 1179
Query: 3610 FANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPIL 3732
A+P + YFA+ KI +DQ+ D+AARK + ++ E WL+P+L
Sbjct: 1180 IAHPAAAYFAIPKIGRDQLEDWAARKGMSLKDAEYWLAPLL 1220
>gi|32476113|ref|NP_869107.1| 5-methyltetrahydrofolate--homocysteine
methyltransferase [Pirellula sp. 1]
gi|32446657|emb|CAD76493.1| 5-methyltetrahydrofolate--homocysteine
methyltransferase [Pirellula sp.]
Length = 1246
Score = 1189 bits (3076), Expect = 0.0
Identities = 645/1247 (51%), Positives = 851/1247 (67%), Gaps = 9/1247 (0%)
Frame = +1
Query: 28 LAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRPDIIYKI 207
LAE+ +ERI+++DGAMGTMIQR ++E R + DH K LK +D+L +T P+ I +I
Sbjct: 23 LAELIRERILMLDGAMGTMIQRLELDEAAVRSDRFADHHKDLKNFSDILCLTHPEKITEI 82
Query: 208 HKLYLEAGADFVETNTFSGTTIAQADYRCE-HLVHEINYQSALVARRACDDVGAAT-GRR 381
H Y EAG+D VETN+F + I ++ LV+EIN + AR+A D T +
Sbjct: 83 HSKYYEAGSDIVETNSFGASPIGMVEFDLPLELVNEINVAAVACARKAADQWTEKTPDKP 142
Query: 382 RYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVETVFDS 561
R+V G+IGPT L+IS VE FR TF +L +Y Q +SL + GVD+LL ET D+
Sbjct: 143 RFVAGSIGPTTMQLAISTDVEDAAFRATTFDKLADSYYAQVKSLCEAGVDILLPETAIDT 202
Query: 562 ANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRT-LSGQTGEAFLVSTKQGKPMAVG 738
N K+ LFAI+ F DEG +PV +SGT D GRT +SGQ+ EAF+ + ++VG
Sbjct: 203 LNLKSCLFAIQRYF-DEGGRRVPVMVSGTF-DKGGRTFVSGQSVEAFVTALSHFPVLSVG 260
Query: 739 LNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFARDGLV 918
+NCALG MR V+ MSK + I C+PNAGLPN +G +D P+ MA+++ E+A +G +
Sbjct: 261 MNCALGPDIMRPHVEEMSKATGLPISCHPNAGLPNEMGAFDLDPKPMAEIVGEYADNGWI 320
Query: 919 NIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKML--LSGLEPSIVGPETNFVNIG 1092
NI+GGCCGTTPDHI M + VQG P+ Q+ +G + LSG P ++ PE F +G
Sbjct: 321 NILGGCCGTTPDHIRVMTERVQGCKPK---QEDKSGPVWTRLSGQLPMVMRPEIPFTMVG 377
Query: 1093 ERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLRLI 1272
ER NV GSR+F LI+NE YD A++VAR QV++GA I+DVN DD LLDG AM++FLRLI
Sbjct: 378 ERTNVTGSRKFARLIRNEEYDEAVEVAREQVENGATIIDVNFDDALLDGVEAMTRFLRLI 437
Query: 1273 SSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGAAV 1452
+ + VA +PV IDSS ++VI AGL++ QGK +VNSISLK+GEE+F RAR++++YGAA
Sbjct: 438 AGDSVVAAVPVMIDSSRWEVIEAGLQNVQGKAIVNSISLKDGEEEFLRRARLVRQYGAAT 497
Query: 1453 VVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNYGM 1632
VVMAFDE+GQAA+ D K IC+R+Y +L EV F P DIIFD NILT+ATGMEEH+NY +
Sbjct: 498 VVMAFDEEGQAADEDNKVRICKRAYDLLVNEVHFPPEDIIFDPNILTVATGMEEHNNYAV 557
Query: 1633 YFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVNAG 1812
F+ A I++ PGA SGGVSNISFSFRG + +REA+HS FL+ A+KAG+DMGIVNAG
Sbjct: 558 DFVNAVERIKKECPGAKTSGGVSNISFSFRGNDPVREAIHSAFLYRAVKAGLDMGIVNAG 617
Query: 1813 ALPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEMXXXXXXXXXXXXEWRSLTVEER 1992
L VYE+I K +NR +AT+++L A+ + WR ++EER
Sbjct: 618 QLEVYEEIPKDLLEHVEDVLWNRRDDATDRMLEFAETVKGSGKKKSGEDLTWRENSIEER 677
Query: 1993 LKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFLPQVI 2172
+K AL+KG+D+++V DTEEARQ+ Y + L++IE PLM GM+VVG+LFG GKMFLPQV+
Sbjct: 678 MKHALIKGIDKYIVEDTEEARQH---YDKCLHIIEGPLMAGMSVVGDLFGQGKMFLPQVV 734
Query: 2173 KSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKNIVSV 2352
KSARVMKKAVA+L PFME Q IE+ + +G +IATVKGDVHDIGKNIV V
Sbjct: 735 KSARVMKKAVAYLEPFME---QEKIES---GTQDHKARGKFLIATVKGDVHDIGKNIVGV 788
Query: 2353 VLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRVGLNI 2532
VL CNN++V+DLGVM E I++ A+++ AD IGLSGLITPSLDEMV+VA+EM R+G+
Sbjct: 789 VLQCNNYEVIDLGVMVSSEKILEEAVKQDADMIGLSGLITPSLDEMVHVAREMKRIGMKK 848
Query: 2533 PLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLNEDYE 2712
PLL+GGATTS HTAV+I+P Y PV+H LDAS+SV V L RDAFL+ + E
Sbjct: 849 PLLVGGATTSAKHTAVRIAPAYDGPVLHVLDASRSVGVVEKLLSDESRDAFLEANVSEQE 908
Query: 2713 DVRQEHYASLKDRRFT--DLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIPYI 2886
+ +S ++R+ T + EK+F+ DW+ +P F+G + ++F L L YI
Sbjct: 909 KL----VSSFRERKQTLVSYEQALEKRFQTDWETVRIDQPEFIGTKVLEDFPLATLREYI 964
Query: 2887 DWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAVVS 3066
DW P+F W+L+GK YPKIF D VG AK+VF+ A L ++IDEK++ A V
Sbjct: 965 DWSPYFMTWELKGK-----YPKIFQDETVGPIAKEVFEKANKMLDRVIDEKLIRAKGVYG 1019
Query: 3067 FLPAASEGDDMHVYDPETGNKLDT-FYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDDYL 3243
F PAAS+GDD+ VY E+ + T F+ LRQQ R + L+D+I P+ +G DYL
Sbjct: 1020 FWPAASDGDDIIVYTDESRTEERTRFHCLRQQWERRGQKDFRSLADYIAPVDSG-RKDYL 1078
Query: 3244 GLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYSTNE 3423
G FA TAGLGAEE +K DD +SI+ A+ADR AEA+AEYLH++VR W Y E
Sbjct: 1079 GGFAVTAGLGAEELSMRFKKELDDESSIIASAVADRCAEAFAEYLHQQVRQQ-WQYGKEE 1137
Query: 3424 DLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKN-GIGLTEHLAMLPAASVS 3600
+L+ D+++ KY+GIRPA GYP+ PDHTEKRTL+ LLEAEKN GI LTE AM P ASVS
Sbjct: 1138 NLSNEDMIAEKYRGIRPAAGYPACPDHTEKRTLFDLLEAEKNTGINLTESYAMSPGASVS 1197
Query: 3601 GLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGYD 3741
GLYF++P ++YF V ++ +DQ+ YAARK P EVERWLSP L YD
Sbjct: 1198 GLYFSHPDAKYFTVDRMTKDQIESYAARKGWPISEVERWLSPNLAYD 1244
>gi|15805990|ref|NP_294690.1| 5-methyltetrahydrofolate--homocysteine
methyltransferase [Deinococcus radiodurans R1]
gi|7471022|pir||D75453 5-methyltetrahydrofolate-homocysteine
S-methyltransferase (EC 2.1.1.13) DR0966 [similarity] -
Deinococcus radiodurans (strain R1)
gi|6458693|gb|AAF10543.1| 5-methyltetrahydrofolate--homocysteine
methyltransferase [Deinococcus radiodurans]
Length = 1258
Score = 1179 bits (3049), Expect = 0.0
Identities = 646/1258 (51%), Positives = 843/1258 (66%), Gaps = 21/1258 (1%)
Frame = +1
Query: 28 LAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRPDIIYKI 207
+ E A++RI+I+DGA GT +QR + E DFR + D + +GN DLL +T+PD+I +
Sbjct: 22 ITEAARQRILILDGAWGTQLQRANLTEADFRWDEA-DPTRMYRGNFDLLQLTKPDVIRAV 80
Query: 208 HKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAATGRRRY 387
H+ Y EAGAD TNTF+ TTI+QADY E L + +N + A +AR D+ A G++R+
Sbjct: 81 HRAYFEAGADIASTNTFNSTTISQADYGTEALAYAMNREGARLAREVADEFEARDGKKRW 140
Query: 388 VCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVETVFDSAN 567
V G++GPTNRT ++SP VE+P+FRNVT+ +LV AY + L++GG D+LL+ETVFD+ N
Sbjct: 141 VAGSVGPTNRTATLSPDVERPEFRNVTYDDLVAAYSEAITGLMEGGADLLLIETVFDTLN 200
Query: 568 AKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKPMAVGLNC 747
AKAALFA + +F +G E+PV LSGTI D SGRTLSGQT EAF VST+ ++GLNC
Sbjct: 201 AKAALFAAQDVFAAQG-RELPVMLSGTITDASGRTLSGQTPEAFAVSTEHAGLFSLGLNC 259
Query: 748 ALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFARDGLVNII 927
ALGA +R + ++ +++ + +PNAGLPNA G YDETPE A VL +FAR+GLVNI+
Sbjct: 260 ALGADLLRPHLRAIAANTEALVSVHPNAGLPNAFGEYDETPEHTAAVLADFAREGLVNIV 319
Query: 928 GGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVNIGERCNV 1107
GGCCGTTP+HI A+ +AV+ I PR Q P + LSGLE + PETNFVN+GER NV
Sbjct: 320 GGCCGTTPEHIKAIAEAVKDIPPRQALQLPPY--LRLSGLEAFTLTPETNFVNVGERTNV 377
Query: 1108 AGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLRLISSEPD 1287
GS +F I +YD + +AR QV +GAQI+D+N D+G+LDG AM KFL L++ EPD
Sbjct: 378 TGSPKFSKAILAGDYDAGLKIARQQVTNGAQIVDINFDEGMLDGEGAMVKFLNLLAGEPD 437
Query: 1288 VAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGAAVVVMAF 1467
++++P+ +DSS ++++ AGL QGK VVNSISLK+GE +F ERAR+++RYGAA VVMAF
Sbjct: 438 ISRVPLMLDSSKWEILEAGLRRVQGKAVVNSISLKDGEARFLERARLLRRYGAAAVVMAF 497
Query: 1468 DEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNYGMYFIEA 1647
DEQGQA + EI R+YR+LTE+ F P DIIFD N+LT+ATG+EEH Y + FIEA
Sbjct: 498 DEQGQADNLARRREILGRAYRLLTEQADFPPQDIIFDPNVLTVATGIEEHDRYALDFIEA 557
Query: 1648 ARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVNAGALPVY 1827
R I+ENLP A VSGG+SN+SFSFRG +REAMH+VFL++AI+AG+DMGIVNAG L VY
Sbjct: 558 TRWIKENLPAAKVSGGISNVSFSFRGNNHVREAMHAVFLYHAIRAGLDMGIVNAGMLAVY 617
Query: 1828 EDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEMXXXXXXXXXXXXEWRSLTVEERLKFAL 2007
EDI+ R P+ATE+LL A + WR L V+ERL+ AL
Sbjct: 618 EDIEPELREAVEDVILARRPDATERLLTLA-DRYKDIKRESAAQSAWRDLPVQERLRHAL 676
Query: 2008 VKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFLPQVIKSARV 2187
V+GV V D E A Q PL VIE PLMDGM VVG+LFGAGKMFLPQV+KSARV
Sbjct: 677 VQGVADHVDEDAEAAYQELGS---PLAVIEGPLMDGMNVVGDLFGAGKMFLPQVVKSARV 733
Query: 2188 MKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKNIVSVVLGCN 2367
MKKAVA+L P++E E+ ES +G V++ATVKGDVHDIGKNIV VVL CN
Sbjct: 734 MKKAVAYLTPYLEAEKA-----------ESSSKGKVLLATVKGDVHDIGKNIVGVVLACN 782
Query: 2368 NFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRVGLNIPLLIG 2547
++V DLGVM P E I+ A AD IGLSGLITPSLDEMV VA+EM R G+ PLLIG
Sbjct: 783 GYQVTDLGVMVPGEKILDEAERLGADVIGLSGLITPSLDEMVNVAREMTRRGVKTPLLIG 842
Query: 2548 GATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLNEDYEDVRQE 2727
GATTS+ HTAVKI P Y VVH LDAS++V V + L ++ A+ + +Y+ +R+
Sbjct: 843 GATTSRAHTAVKIDPAYDGTVVHVLDASRAVTVTNDL--LTDEAAYAGRVQGEYDTLRER 900
Query: 2728 HYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPS--FVGRREYQNFDLNELIPYIDWKPF 2901
H + R L + R + ++ AV P+ +GR+ + + EL+P+IDW PF
Sbjct: 901 H--GERQVRLIALAEARARAPQLS----AAVPPAPHDLGRQVVEQ-PIAELLPFIDWTPF 953
Query: 2902 FDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAVVSFLPAA 3081
F W+++G YP I D G EA+K+F DAQ L+++I + L A V+ PA
Sbjct: 954 FIAWEMKGIYPG-----ILTDPLRGEEARKLFADAQALLEQVIADGSLRARGVIGLWPA- 1007
Query: 3082 SEGDDMHVYDPETGN-------------------KLDTFYGLRQQSGREHDQPHFCLSDF 3204
GDD+ + D G + + LRQQ R+ P+ L+DF
Sbjct: 1008 -HGDDIVLDDAAMGRGETLDFETHELAAGREPLPNMPRLHTLRQQ--RDQTTPNTALADF 1064
Query: 3205 IKPLKNGVPDDYLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHK 3384
+ D++G FA TA GAEE + E HDDY SI+VKA+ADRLAEA+AE LH+
Sbjct: 1065 V-----AEGGDHIGAFA-TAIFGAEELAQQFEAQHDDYNSILVKAVADRLAEAFAEKLHR 1118
Query: 3385 EVRTTLWGYSTNEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKNGIGLT 3564
+VR WGY+ E L +DL+ +YQGIRPA GYP+QPDHTEKRTL++LL+AE G+ LT
Sbjct: 1119 DVRVRHWGYAEGEALDNTDLIKERYQGIRPAPGYPAQPDHTEKRTLFELLDAESIGLRLT 1178
Query: 3565 EHLAMLPAASVSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGY 3738
E AM PAA+VSGLYFA+P++ YFAVG+I +DQV +YAARK +E ERWL P+L Y
Sbjct: 1179 ESCAMTPAAAVSGLYFAHPEARYFAVGRIGRDQVENYAARKGWTVQEAERWLGPLLAY 1236
>gi|15893867|ref|NP_347216.1| Cobalamine-dependent methionine synthase
I (methyltransferase and cobalamine-binding domain)
[Clostridium acetobutylicum ATCC 824]
gi|25285953|pir||A96971 cobalamine-dependent methionine synthase I
(methyltransferase and cobalamine-binding domain)
[imported] - Clostridium acetobutylicum
gi|15023446|gb|AAK78556.1| Cobalamine-dependent methionine synthase I
(methyltransferase and cobalamine-binding domain)
[Clostridium acetobutylicum ATCC 824]
Length = 1212
Score = 1165 bits (3014), Expect = 0.0
Identities = 622/1238 (50%), Positives = 829/1238 (66%), Gaps = 3/1238 (0%)
Frame = +1
Query: 28 LAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRPDIIYKI 207
L + +I+++DGAMGT IQ ++E DF+G + KGNND+L++T+P+II +I
Sbjct: 5 LKNLLNNKILVLDGAMGTCIQSFNLDEGDFKGSLSCTCHSNQKGNNDVLNLTKPEIIKEI 64
Query: 208 HKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAATGRR-R 384
HK YLEAGAD +ETNTF+ T I+Q DY + +++IN++ A +A+ AC + R
Sbjct: 65 HKRYLEAGADIIETNTFNATEISQKDYNMQDKIYDINFKGAKLAKEACTYYTKLNPNKPR 124
Query: 385 YVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVETVFDSA 564
+ G+IGPTNRT S+SP VE P FRNVTF EL AY Q +LI GGVD+LL+ET+FD+
Sbjct: 125 FAAGSIGPTNRTASLSPDVENPGFRNVTFDELCNAYKHQIEALIDGGVDLLLIETIFDTL 184
Query: 565 NAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKPMAVGLN 744
NA+AA+FA T+FE++ + ++P+ +SGTI D SGR LSGQT +AF S K +A+GLN
Sbjct: 185 NARAAIFAAETVFENKKI-KLPIIISGTIADKSGRILSGQTLDAFAESLKNENIIAIGLN 243
Query: 745 CALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFARDGLVNI 924
C+ GA+++ F+ +S+ + +I +PNAGLPN+LG Y+E PEE A ++++ A +G +NI
Sbjct: 244 CSFGAEELIPFIKRLSETQNRYISFHPNAGLPNSLGEYEELPEETASIVKKLALEGHLNI 303
Query: 925 IGGCCGTTPDHINAMYKAVQGITPR-VPPQDPHAGKMLLSGLEPSIVGPETNFVNIGERC 1101
+GGCCGTTP+HI A+ V+GI+PR VP +P K + SGLE + +NF+NIGER
Sbjct: 304 VGGCCGTTPEHIRAISSVVKGISPRKVPNLEP---KTIYSGLENIKIDKNSNFINIGERT 360
Query: 1102 NVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLRLISSE 1281
NVAGSR+F LI+ +NY+ A+ +AR QV++GAQI+D+N DD LLD M FLRLI+SE
Sbjct: 361 NVAGSRKFARLIREKNYEEALTIARHQVENGAQIIDINFDDALLDARSEMETFLRLIASE 420
Query: 1282 PDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGAAVVVM 1461
P+++K+PV IDSS+F+V+ GL+S QGK +VNSISLK GEEKF E A+ IK +GA VVVM
Sbjct: 421 PEISKVPVMIDSSNFEVLKVGLKSIQGKAIVNSISLKVGEEKFIEEAKFIKNFGAGVVVM 480
Query: 1462 AFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNYGMYFI 1641
AFDE+GQAA + K EIC+R+Y ILTE+V F P +IIFD NIL+IATG+EEH NY + +I
Sbjct: 481 AFDEEGQAATYERKIEICKRAYTILTEKVEFPPENIIFDPNILSIATGIEEHDNYAVNYI 540
Query: 1642 EAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVNAGALP 1821
+A + I+ENLP A VSGGVSN+SFSFRG +AIR AMHSVFL++AI AGMDMGIVN +
Sbjct: 541 KAVKWIKENLPYAKVSGGVSNLSFSFRGNDAIRRAMHSVFLYHAINAGMDMGIVNPAMID 600
Query: 1822 VYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEMXXXXXXXXXXXXEWRSLTVEERLKF 2001
+Y+DIDK N+ A+E LL AQ EWR + ERL +
Sbjct: 601 LYDDIDKDLLEKVENVVLNKSSNASESLLEFAQTYKKTTETLEKHEDEWRQKSPSERLSY 660
Query: 2002 ALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFLPQVIKSA 2181
ALVKG +F+ D EEAR+ +Y L +IE PLM+GM VG+LFG GKMFLPQV+KSA
Sbjct: 661 ALVKGNVEFIEEDIEEARK---EYTNALEIIEVPLMNGMKKVGKLFGEGKMFLPQVVKSA 717
Query: 2182 RVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKNIVSVVLG 2361
RVMKKAV LLP++ E+ N + G VV ATVKGDVHDIGKNIVSVVL
Sbjct: 718 RVMKKAVECLLPYINEEKSKN---------HNKSAGKVVFATVKGDVHDIGKNIVSVVLS 768
Query: 2362 CNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRVGLNIPLL 2541
CNNF+V+DLGVM P E I++ A E AD I LSGLITPSL+EM YVA+EM R+ +IPL+
Sbjct: 769 CNNFEVIDLGVMVPPETILETAKRENADIIALSGLITPSLNEMAYVAEEMKRLNFDIPLM 828
Query: 2542 IGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLNEDYEDVR 2721
+GGA TSKTHTA+K++ +Y + VVH DAS +V V +L + + FL+ LNE+Y +R
Sbjct: 829 VGGAATSKTHTALKLATKYKY-VVHSTDASDAVTVAKNLMSEN-KFTFLEKLNEEYSKIR 886
Query: 2722 QEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIPYIDWKPF 2901
+ S + R+ +F IDW+K +P FVG ++ Q +NEL YIDW F
Sbjct: 887 ETF--STNKIELISIQNARKNRFTIDWNKTKITEPKFVGIKKLQAVPINELRKYIDWTFF 944
Query: 2902 FDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAVVSFLPAA 3081
F W + +YPKI D GAEA+K+F DA L L E ++ N V PA
Sbjct: 945 FTSWDM-----GMNYPKIMKDPKYGAEAQKLFKDANEMLDLLQKENLITCNGVFGIFPAN 999
Query: 3082 SEGDDMHVYDPETGNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDDYLGLFACT 3261
S DD+ +Y T T LRQQ + D + LSD+I P G+ DY+G F T
Sbjct: 1000 SVNDDIEIY---TDKGTVTINTLRQQQILK-DSDYKALSDYIAPKGIGI-KDYIGGFIVT 1054
Query: 3262 AGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYSTNEDLTESD 3441
AG+GA+EY L+K DDY + M+K + DRLAEA++E LH VR WGYS +E+L+
Sbjct: 1055 AGIGAKEYSDKLKKKCDDYGATMLKLICDRLAEAFSELLHLRVRKEYWGYSQDENLSLEK 1114
Query: 3442 LLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKN-GIGLTEHLAMLPAASVSGLYFAN 3618
LL Y+GI+PA GYPS PDH+EK L+ LL + + G+ LTE M P +SV GLYFAN
Sbjct: 1115 LLKGSYRGIKPAIGYPSIPDHSEKAKLFDLLLGKTSIGVELTESYMMNPTSSVCGLYFAN 1174
Query: 3619 PQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPIL 3732
+++YF + KI +DQ+ DYA R N E+++ L +L
Sbjct: 1175 ERAKYFNINKIGKDQLEDYAVRSNKDINEIKKLLDTLL 1212
>gi|46141188|ref|ZP_00145376.2| COG1410: Methionine synthase I,
cobalamin-binding domain [Psychrobacter sp. 273-4]
Length = 1271
Score = 1157 bits (2994), Expect = 0.0
Identities = 620/1255 (49%), Positives = 835/1255 (66%), Gaps = 13/1255 (1%)
Frame = +1
Query: 7 RSSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITR 186
R+ + E++A RI+++DGAMGT IQ +EE D+RGE + + ++GNNDLL +T+
Sbjct: 47 RTRITEQMAA----RILMLDGAMGTHIQNYKLEEADYRGERFANISQDVRGNNDLLVLTQ 102
Query: 187 PDIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGA 366
P +I +IH +LE+GAD +ETN+F+GT ++ ADY ++LV E+N +A +AR A D+ A
Sbjct: 103 PHMIKEIHLAHLESGADIIETNSFNGTRLSMADYDMQYLVPELNKTAAKIAREAADEYTA 162
Query: 367 AT-GRRRYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLV 543
+ R+V G IGPT+RT S+SP V P FRN+TF ELV Y + +L++GGVD++L+
Sbjct: 163 KNPDKPRFVAGVIGPTSRTCSLSPDVNDPAFRNITFDELVLNYREATLALMEGGVDIILI 222
Query: 544 ETVFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGK 723
ET+FD+ NAKAA+FA+ +F+D G E+P+ +SGTI D SGRTLSGQT EAF S + K
Sbjct: 223 ETIFDTLNAKAAIFAVTGVFDDIGF-ELPIMISGTITDASGRTLSGQTAEAFYNSIRHAK 281
Query: 724 PMAVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFA 903
P++VG NCALGA +R + +S +++++ +PNAGLPN G YDET +E A +L FA
Sbjct: 282 PLSVGFNCALGADALRPHIQTLSNIANTYVSAHPNAGLPNEFGEYDETADETAALLEGFA 341
Query: 904 RDGLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFV 1083
+ G++NI+GGCCGTTP+HI + V PRV P+ A + LSGLEP + ++ FV
Sbjct: 342 KAGILNIVGGCCGTTPEHIRQIANMVAKYPPRVIPEIAPACR--LSGLEPFTINSDSLFV 399
Query: 1084 NIGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFL 1263
N+GER NV GS++F LIK E Y A+DVAR QV+ GAQI+D+NMD+G+LD AM F+
Sbjct: 400 NVGERTNVTGSKKFLRLIKTEAYTEALDVARDQVEGGAQIVDINMDEGMLDSKQAMIHFV 459
Query: 1264 RLISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYG 1443
L+S EPD++++P+ +DSS +D+I GL+ TQGKC+VNSISLKEG +F ERA++ RYG
Sbjct: 460 NLVSGEPDISRVPLMLDSSKWDIIEEGLKRTQGKCIVNSISLKEGHAEFVERAKLCMRYG 519
Query: 1444 AAVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSN 1623
AA++VMAFDE GQA + K +IC+RSY +L +EVGF DIIFD NI +ATG+ EH+N
Sbjct: 520 AAIIVMAFDEDGQADTFERKTQICKRSYDVLVDEVGFPSEDIIFDPNIFAVATGITEHNN 579
Query: 1624 YGMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIV 1803
YG FI A + I +NLP A VSGGVSN+SFSFRG IREA++SVFL++AI+ G+ MGIV
Sbjct: 580 YGADFINATKWITDNLPNAMVSGGVSNVSFSFRG-NPIREAINSVFLYHAIQNGLTMGIV 638
Query: 1804 NAGALPVYEDIDKPXXXXXXXXXFNRD-----PEATEKLLVAAQE-MXXXXXXXXXXXXE 1965
N L +Y+DI K NR+ +ATE+L+ A+
Sbjct: 639 NPAMLELYDDIPKEARDAIEDVMLNRNQGETGQDATERLMTIAENYQDGGKKKESTVDMT 698
Query: 1966 WRSLTVEERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGA 2145
WR TVEER+ ALVKG+ F+ ADT+EA + KYPRPL VIE PLMDGM +VG+LFGA
Sbjct: 699 WREGTVEERIAHALVKGITTFIEADTKEAWE---KYPRPLEVIEGPLMDGMNIVGDLFGA 755
Query: 2146 GKMFLPQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVH 2325
GKMFLPQV+KSARVMK++VA L P++E E+ E +G +++ATVKGDVH
Sbjct: 756 GKMFLPQVVKSARVMKQSVAWLNPYIEAEKV-----------EGEKKGKILMATVKGDVH 804
Query: 2326 DIGKNIVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAK 2505
DIGKNIV VVLGCN + +VDLGVM PCE I+ AI E+ D IGLSGLITPSLDEMVYVAK
Sbjct: 805 DIGKNIVGVVLGCNGYDIVDLGVMVPCEKILDTAIAEEVDIIGLSGLITPSLDEMVYVAK 864
Query: 2506 EMNRVGLNIPLLIGGATTSKTHTAVKISPRYPH-PVVHCLDASKSVVVCSSLSDMSVRDA 2682
+M G+ +PL+IGGATTSK HTAVKI P+Y + V++ DAS+SV V + L R
Sbjct: 865 QMQERGMTLPLMIGGATTSKAHTAVKIEPQYQNDAVIYVSDASRSVGVVTKLLSKEHRQG 924
Query: 2683 FLQDLNEDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFD 2862
+ + E+Y VR+ ++ E F+ DWD + P+ +G+ + ++
Sbjct: 925 LIDETREEYIKVRERLAKRQPKAAKISYAESIEIGFQYDWDNYVPPTPNKLGQVIFDDYP 984
Query: 2863 LNELIPYIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKI 3042
+ L+PYIDW PFF W L GK YPKI D VG A+ +F +A+ L+K+IDEK+
Sbjct: 985 ITNLLPYIDWTPFFISWGLAGK-----YPKILQDDVVGEAARDLFGNAEDMLQKMIDEKL 1039
Query: 3043 LVANAVVSFLPAASEG-DDMHVYD---PETGNKLDTFYGLRQQSGREHDQPHFCLSDFIK 3210
+VA V +PA G D + VYD E G F LRQQS + +P+F L+DFI
Sbjct: 1040 IVAKGVFKLMPACRTGADTVTVYDKAPTEGGTAEYQFEHLRQQSDKASGKPNFSLADFIS 1099
Query: 3211 PLKNGVPDDYLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEV 3390
P + + DYLG F + +G E + + DDY +IMV+AL+DRLAEA+AE+LH+ +
Sbjct: 1100 P--SDMHTDYLGGFTVSI-VGTEALAEKYKAAGDDYNAIMVQALSDRLAEAFAEHLHELI 1156
Query: 3391 RTTLWGYSTNEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLL-EAEKNGIGLTE 3567
R WGY E LT D++ KY GIRPA GYP+ P+HTEK L++ L + G LTE
Sbjct: 1157 RKEYWGYQPTESLTNEDMIKEKYVGIRPAPGYPACPEHTEKGKLFEWLGTGDAIGTILTE 1216
Query: 3568 HLAMLPAASVSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPIL 3732
AM PA+SVSG Y+++P S YF VGKI DQ+ YA RK + E+WL+P L
Sbjct: 1217 SYAMWPASSVSGFYYSHPDSVYFNVGKISTDQLESYAERKGWDMKTAEKWLNPNL 1271
>gi|48833218|ref|ZP_00290240.1| COG1410: Methionine synthase I,
cobalamin-binding domain [Magnetococcus sp. MC-1]
Length = 1217
Score = 1156 bits (2991), Expect = 0.0
Identities = 625/1241 (50%), Positives = 824/1241 (66%), Gaps = 4/1241 (0%)
Frame = +1
Query: 22 EELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRPDIIY 201
E+ + ++RI+I+DGAMGTMIQR +EE D+RG DH L G NDLL +T+P +I
Sbjct: 7 EQFRTLLQQRILILDGAMGTMIQRLGLEEADYRGSRFADHPAELHGANDLLVLTKPQVIR 66
Query: 202 KIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAAT-GR 378
IH YLEAGAD VETNTF+G + DY E LV+E+N + A VAR+ACD V A GR
Sbjct: 67 NIHTAYLEAGADIVETNTFNGNAPSLGDYGLEALVYEVNLEGARVARQACDAVMAQQPGR 126
Query: 379 RRYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVETVFD 558
+V G +GPTNRT SISP V P FRN+ F LV Y + R L+ GG D+LLVETVFD
Sbjct: 127 ICFVAGVLGPTNRTCSISPDVNNPGFRNIDFDALVADYANGTRGLLDGGADILLVETVFD 186
Query: 559 SANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKPMAVG 738
+ N KAALFA+R + E + ++P+ +S TI D SGRTL+GQT EAF S +P +G
Sbjct: 187 TLNCKAALFAVRQVLEQRQL-DLPLMISFTITDQSGRTLTGQTVEAFWNSVSHARPDTIG 245
Query: 739 LNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFARDGLV 918
+NCALGA +R ++ +++ + + I +PNAGLPNA G YDETP MAD + FA+ GL+
Sbjct: 246 MNCALGADQLRPHLETLAEIAATRISVHPNAGLPNAFGEYDETPAMMADKVVAFAQGGLI 305
Query: 919 NIIGGCCGTTPDHINAMYKAVQGITPR-VPPQDPHAGKMLLSGLEPSIVGPETNFVNIGE 1095
NI+GGCCGT+PDHI A+ + V G+ PR +P P LSGLEP + ++ FVN+GE
Sbjct: 306 NIVGGCCGTSPDHIRAIAQRVAGLAPRQIPTLKPACH---LSGLEPLTIDADSLFVNVGE 362
Query: 1096 RCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLRLIS 1275
R NVAGS RF LI+ Y+TA+ VAR QV+SGAQI+DVNMDD +LD AM FL L++
Sbjct: 363 RTNVAGSARFARLIREGQYETALAVAREQVESGAQIVDVNMDDAMLDAQSAMVTFLNLMA 422
Query: 1276 SEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGAAVV 1455
+EP+++++PV IDSS++ V+ AGL+ QGKC++NS+SLKEG+E F ++A + +RYGAAV+
Sbjct: 423 AEPEISRVPVMIDSSEWRVLEAGLKCVQGKCIINSLSLKEGDEPFLKQAHLARRYGAAVI 482
Query: 1456 VMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNYGMY 1635
VMAFDEQGQA + +IC+R+Y +L VG PNDIIFD NI +ATG+EEH+NY +
Sbjct: 483 VMAFDEQGQADSYQRRIDICQRAYDLLVHTVGMEPNDIIFDPNIFAVATGIEEHNNYAVE 542
Query: 1636 FIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVNAGA 1815
FI+A R I++NLPGA +SGGVSN+SFSFRG +REAMH+VFL++AI AGMDMGIVNAG
Sbjct: 543 FIQATRWIKQNLPGARISGGVSNVSFSFRGNNPVREAMHAVFLYHAIAAGMDMGIVNAGQ 602
Query: 1816 LPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEMXXXXXXXXXXXXEWRSLTVEERL 1995
L VYE+I NR +AT++LL A WRS V+ RL
Sbjct: 603 LAVYEEIPVDLRERVEDVILNRRSDATDRLLEVADHYRQSGVTEDKADAAWRSEPVQARL 662
Query: 1996 KFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFLPQVIK 2175
+ A++KG+ +F+ AD EEAR A PL V+E PLM GM VG+LFG GKMFLPQV+K
Sbjct: 663 RHAMIKGITEFIDADVEEARSLAA---HPLEVVEGPLMAGMNAVGDLFGEGKMFLPQVVK 719
Query: 2176 SARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKNIVSVV 2355
SARVMK+AVA+L+P +E +AN G E+ + G +++ATVKGDVHDIGKNIV VV
Sbjct: 720 SARVMKQAVAYLVPHIE---EAN--RQGGIENRASGAGKILLATVKGDVHDIGKNIVKVV 774
Query: 2356 LGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRVGL-NI 2532
L CNNF+V DLGVM E I+ A E A IGLSGLITPSL +M +VAKEM R G+ +I
Sbjct: 775 LQCNNFEVEDLGVMVAVETILDRAQESGAQIIGLSGLITPSLQQMTHVAKEMQRRGMQHI 834
Query: 2533 PLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLNEDYE 2712
PLLIGGATTSK HTAVKI+P VV DAS+SV V ++L RD F+ ++E
Sbjct: 835 PLLIGGATTSKAHTAVKIAPVTEGCVVQVKDASRSVGVAAALLSARERDDFMAACVAEHE 894
Query: 2713 DVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIPYIDW 2892
R H + + + R + F A +P G ++DL L+PYIDW
Sbjct: 895 KYRAIHEQRSTRKPLLSMQEARARAFATPAAVTQAAQP---GVHVLADYDLATLVPYIDW 951
Query: 2893 KPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAVVSFL 3072
PFF W+L G+ YP+I D+ VG A ++F+DAQ L+++I + L AN V+
Sbjct: 952 TPFFRTWELHGR-----YPEILSDSKVGQAATRLFEDAQQMLQEIIAQGSLKANGVLGLF 1006
Query: 3073 PAASEGDDMHVYDPETGNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDDYLGLF 3252
A+ GDD+ E + L T + LRQQ + P + L+DF+ D +G+F
Sbjct: 1007 NASRVGDDI-----ELADGLGTIHTLRQQRD-GGEAPCYALADFVG------QGDTIGMF 1054
Query: 3253 ACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYSTNEDLT 3432
A TAG+G E + HDDY +IMV+ALADRLAEA+AE++H+ R WGY+ +E L+
Sbjct: 1055 AVTAGIGVAELVAHHQAAHDDYRAIMVEALADRLAEAFAEHIHERARREFWGYAGDEALS 1114
Query: 3433 ESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKN-GIGLTEHLAMLPAASVSGLY 3609
+ DL++ +Y GIRPA GYP+ PDHTEK L+K L A+++ G+ LTE AM PAASVSG
Sbjct: 1115 KGDLIAERYVGIRPAPGYPACPDHTEKALLFKCLNAQEHAGMALTESFAMTPAASVSGYL 1174
Query: 3610 FANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPIL 3732
FA+PQ+ YF+VG+I DQ+ YA RK + EE+ +WL+P L
Sbjct: 1175 FAHPQARYFSVGRIGGDQLEAYAKRKGMSVEEMAKWLAPNL 1215
>gi|34365461|emb|CAE46059.1| hypothetical protein [Homo sapiens]
Length = 819
Score = 1021 bits (2639), Expect = 0.0
Identities = 516/849 (60%), Positives = 640/849 (74%), Gaps = 8/849 (0%)
Frame = +1
Query: 1225 GLLDGPYAMSKFLRLISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEE 1404
G+LDGP AM++F LI+SEPD+AK+P+CIDSS+F VI AGL+ QGKC+VNSISLKEG
Sbjct: 1 GMLDGPSAMTRFCNLIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEG-- 58
Query: 1405 KFKERARIIKRYGAAVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDAN 1584
QA ETD K +C R+Y +L +++GFNPNDIIFD N
Sbjct: 59 -------------------------QATETDTKIRVCTRAYHLLVKKLGFNPNDIIFDPN 93
Query: 1585 ILTIATGMEEHSNYGMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFL 1764
ILTI TGMEEH+ Y + FI A ++I+E LPGA +SGG+SN+SFSFRGMEAIREAMH VFL
Sbjct: 94 ILTIGTGMEEHNLYAINFIHATKVIKETLPGARISGGLSNLSFSFRGMEAIREAMHGVFL 153
Query: 1765 FYAIKAGMDMGIVNAGALPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEMXXXXXX 1944
++AIK+GMDMGIVNAG LPVY+DI K +N+DPEATEKLL AQ
Sbjct: 154 YHAIKSGMDMGIVNAGNLPVYDDIHKELLQLCEDLIWNKDPEATEKLLRYAQTQGTGGKK 213
Query: 1945 XXXXXXEWRSLTVEERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAV 2124
EWR+ VEERL++ALVKG+++ ++ DTEEAR N KYPRPLN+IE PLM+GM +
Sbjct: 214 VIQTD-EWRNGPVEERLEYALVKGIEKHIIEDTEEARLNQKKYPRPLNIIEGPLMNGMKI 272
Query: 2125 VGELFGAGKMFLPQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIA 2304
VG+LFGAGKMFLPQVIKSARVMKKAV HL+PFME ER+ G E+E PYQGT+V+A
Sbjct: 273 VGDLFGAGKMFLPQVIKSARVMKKAVGHLIPFMEKEREETRVLNGTVEEEDPYQGTIVLA 332
Query: 2305 TVKGDVHDIGKNIVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLD 2484
TVKGDVHDIGKNIV VVLGCNNF+V+DLGVMTPC+ I+KAA++ KAD IGLSGLITPSLD
Sbjct: 333 TVKGDVHDIGKNIVGVVLGCNNFRVIDLGVMTPCDKILKAALDHKADIIGLSGLITPSLD 392
Query: 2485 EMVYVAKEMNRVGLNIPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSD 2664
EM++VAKEM R+ + IPLLIGGATTSKTHTAVKI+PRY PV+H LDASKSVVVCS L D
Sbjct: 393 EMIFVAKEMERLAIRIPLLIGGATTSKTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLD 452
Query: 2665 MSVRDAFLQDLNEDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDW-DKFTAVKPSFVGR 2841
+++D + +++ E+YED+RQ HY SLK+RR+ L++ R+ F++DW + VKP+F+G
Sbjct: 453 ENLKDEYFEEIMEEYEDIRQGHYESLKERRYLPLSQARKSGFQMDWLPEPHPVKPTFIGT 512
Query: 2842 REYQNFDLNELIPYIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLK 3021
+ ++++DL +L+ YIDWKPFFDVWQLRGKYPNR +PKIF+D VG EA+KV+DDA L
Sbjct: 513 QVFEDYDLQKLVDYIDWKPFFDVWQLRGKYPNRGFPKIFNDKTVGGEARKVYDDAHNMLN 572
Query: 3022 KLIDEKILVANAVVSFLPAASEGDDMHVYD----PETGNKLDTFYGLRQQSGRE--HDQP 3183
LI +K L A VV F PA S DD+H+Y P+ + TFYGLRQQ+ ++ +P
Sbjct: 573 TLISQKKLRARGVVGFWPAQSIQDDIHLYAEAAVPQAAEPIATFYGLRQQAEKDSASTEP 632
Query: 3184 HFCLSDFIKPLKNGVPDDYLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEA 3363
++CLSDFI PL +G+ DYLGLFA A G EE K E + DDY+SIMVKAL DRLAEA
Sbjct: 633 YYCLSDFIAPLHSGI-RDYLGLFA-VACFGVEELSKAYEDDGDDYSSIMVKALGDRLAEA 690
Query: 3364 YAEYLHKEVRTTLWGYSTNEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAE 3543
+AE LH+ VR LW Y +E L +DL ++Y+GIRPA GYPSQPDHTEK T+W+L + E
Sbjct: 691 FAEELHERVRRELWAYCGSEQLDVADLRRLRYKGIRPAPGYPSQPDHTEKLTMWRLADIE 750
Query: 3544 KN-GIGLTEHLAMLPAASVSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWL 3720
++ GI LTE LAM PA++VSGLYF+N +S+YFAVGKI +DQV DYA RKN+ EVE+WL
Sbjct: 751 QSTGIRLTESLAMAPASAVSGLYFSNLKSKYFAVGKISKDQVEDYALRKNISVAEVEKWL 810
Query: 3721 SPILGYDTD 3747
PILGYDTD
Sbjct: 811 GPILGYDTD 819
>gi|29345590|ref|NP_809093.1| 5-methyltetrahydrofolate-homocysteine
methyltransferase [Bacteroides thetaiotaomicron VPI-5482]
gi|29337482|gb|AAO75287.1| 5-methyltetrahydrofolate-homocysteine
methyltransferase [Bacteroides thetaiotaomicron VPI-5482]
Length = 915
Score = 943 bits (2437), Expect = 0.0
Identities = 491/928 (52%), Positives = 644/928 (68%), Gaps = 5/928 (0%)
Frame = +1
Query: 28 LAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRPDIIYKI 207
+++I ERI+I+DGAMGTMIQ+ ++EEDFRGE LKGNNDLL +TRPD+I I
Sbjct: 5 ISQIVSERILILDGAMGTMIQQYNLKEEDFRGERFAHIPGQLKGNNDLLCLTRPDVIQDI 64
Query: 208 HKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAAT-GRRR 384
H+ YLEAGAD +ETNTFS TT++ ADY E V EIN + +AR D+ A + + R
Sbjct: 65 HRKYLEAGADIIETNTFSSTTVSMADYHVEEYVREINLAATRLARELADEYTAKSPDKPR 124
Query: 385 YVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVETVFDSA 564
+V G++GPTN+T S+SP V P FR +++ EL +Y Q ++++GGVD +L+ET+FD+
Sbjct: 125 FVAGSVGPTNKTCSMSPDVNNPAFRALSYDELAASYQQQMEAMLEGGVDAILIETIFDTL 184
Query: 565 NAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKPMAVGLN 744
NAKAA+FA + G+ E+PV LS T+ D+ GRTLSGQT EAFL S + +VGLN
Sbjct: 185 NAKAAIFAAGQAMKVTGI-EVPVMLSVTVSDIGGRTLSGQTLEAFLASVQHANIFSVGLN 243
Query: 745 CALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFARDGLVNI 924
C+ GA+ ++ F++ ++ + +I YPNAGLPN+LG YD+TP +MA ++E+ ++GLVNI
Sbjct: 244 CSFGARQLKPFLEQLASRAPYYISAYPNAGLPNSLGKYDQTPADMAHEVKEYIQEGLVNI 303
Query: 925 IGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVNIGERCN 1104
IGGCCGTT +I + G P VP P M LSGLE V PE NFVNIGERCN
Sbjct: 304 IGGCCGTTDAYIAEYQTLIAGAKPHVPAPKPDC--MWLSGLELLEVKPEINFVNIGERCN 361
Query: 1105 VAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLRLISSEP 1284
VAGSR+F L+ + YD A+ +AR QV+ GA ++DVNMDDGLLD M+ FL LI SEP
Sbjct: 362 VAGSRKFLRLVNEKKYDEALSIARQQVEDGALVIDVNMDDGLLDARTEMTTFLNLIMSEP 421
Query: 1285 DVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGAAVVVMA 1464
++A++PV IDSS ++VI AGL+ QGK +VNSISLKEGEE F E ARIIK+YGAA VVMA
Sbjct: 422 EIARVPVMIDSSKWEVIEAGLKCLQGKSIVNSISLKEGEEVFLEHARIIKQYGAATVVMA 481
Query: 1465 FDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNYGMYFIE 1644
FDE+GQA K E+CER+YR+L ++VGFNP+DIIFD N+L +ATG+EEH+NY + FIE
Sbjct: 482 FDEKGQADTAARKIEVCERAYRLLVDKVGFNPHDIIFDPNVLAVATGIEEHNNYAVDFIE 541
Query: 1645 AARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVNAGALPV 1824
A IR+NLPGAHVSGGVSN+SFSFRG IREAMH+VFL++AI+ GMDMGIVN G +
Sbjct: 542 ATGWIRKNLPGAHVSGGVSNLSFSFRGNNYIREAMHAVFLYHAIQQGMDMGIVNPGTSVL 601
Query: 1825 YEDIDKPXXXXXXXXXFNRDPEATEKLLVAA----QEMXXXXXXXXXXXXEWRSLTVEER 1992
Y DI NR P+A E+L+ A + M WR +V+ER
Sbjct: 602 YSDIPADTLEKIEDVVLNRRPDAAERLIELAEALKETMGGTSGQAAVKQDAWREESVQER 661
Query: 1993 LKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFLPQVI 2172
LK+AL+KG+ ++ D EA Y + ++VIE PLMDGM VGELFGAGKMFLPQV+
Sbjct: 662 LKYALMKGIGDYLEQDLAEA---LPLYDKAVDVIEGPLMDGMNYVGELFGAGKMFLPQVV 718
Query: 2173 KSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKNIVSV 2352
K+AR MKKAVA L P +E E+ + S G V++ATVKGDVHDIGKNIV+V
Sbjct: 719 KTARTMKKAVAILQPIIESEK----------VEGSSSAGKVLLATVKGDVHDIGKNIVAV 768
Query: 2353 VLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRVGLNI 2532
V+ CN + +VDLGVM P E I++ AIEEK D IGLSGLITPSL+EM +VA E+ + GL+I
Sbjct: 769 VMACNGYDIVDLGVMVPAETIVQRAIEEKVDMIGLSGLITPSLEEMTHVAAELEKAGLDI 828
Query: 2533 PLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLNEDYE 2712
PLLIGGATTSK HTA+KI+P Y PVVH DAS++ V S L + ++ + +L+ +Y+
Sbjct: 829 PLLIGGATTSKMHTALKIAPVYHAPVVHLKDASQNASVASRLLNSQMKAELINELDAEYQ 888
Query: 2713 DVRQEHYASLKDRRFTDLNKTREKKFKI 2796
+R++ + L R L + ++ K +
Sbjct: 889 ALREK--SGLLRRETVSLEEAQKNKLNL 914
>gi|48854978|ref|ZP_00309138.1| COG1410: Methionine synthase I,
cobalamin-binding domain [Cytophaga hutchinsonii]
Length = 897
Score = 929 bits (2402), Expect = 0.0
Identities = 495/909 (54%), Positives = 622/909 (67%), Gaps = 3/909 (0%)
Frame = +1
Query: 1024 GKMLLSGLEPSIVGPETNFVNIGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQI 1203
G + LSGLEP IV + FVNIGER NV GS +F LIK Y+ AI+VA QV GAQ+
Sbjct: 6 GTLKLSGLEPLIVDKGSIFVNIGERTNVTGSAKFLRLIKENKYEEAIEVALDQVRGGAQV 65
Query: 1204 LDVNMDDGLLDGPYAMSKFLRLISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSI 1383
+DVNMD+G+LD AM ++L L++SEP+++++PV +DSS + VI AGL+ QGK +VNSI
Sbjct: 66 IDVNMDEGMLDSEAAMVRYLNLLASEPEISRVPVMVDSSKWHVIEAGLKCIQGKGIVNSI 125
Query: 1384 SLKEGEEKFKERARIIKRYGAAVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPN 1563
SLK GE+++ E+AR IK+YGAAVVVMAFDE GQA D + ICERSYR+L +++ FNPN
Sbjct: 126 SLKAGEKEYLEQARKIKKYGAAVVVMAFDEDGQADTYDRRISICERSYRLLVDKLDFNPN 185
Query: 1564 DIIFDANILTIATGMEEHSNYGMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIRE 1743
DIIFD NI +ATG++EH NY + F A R IRENLPGAHVSGGVSN+SFSFRG +RE
Sbjct: 186 DIIFDPNIFPVATGIDEHKNYALDFFRATRWIRENLPGAHVSGGVSNVSFSFRGNNTVRE 245
Query: 1744 AMHSVFLFYAIKAGMDMGIVNAGALPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQE 1923
AMHSVFL+YAIK GMDMGIVN L VYE+I K NR +ATE+LL A
Sbjct: 246 AMHSVFLYYAIKEGMDMGIVNPAMLEVYENIPKDLLERVEDVLLNRRDDATERLLEYADR 305
Query: 1924 MXXXXXXXXXXXXEWRSLTVEERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERP 2103
+ EWR TVEERL +ALVKG +F+ ADTEEARQ KY PL VIE P
Sbjct: 306 V-KGTDKVQVKDLEWRKGTVEERLTYALVKGEIEFIDADTEEARQ---KYVIPLKVIEGP 361
Query: 2104 LMDGMAVVGELFGAGKMFLPQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPY 2283
LM GM VVG+LFG GKMFLPQV+KSARVMKK+VA+L+PF+E E+ N +
Sbjct: 362 LMAGMNVVGDLFGEGKMFLPQVVKSARVMKKSVAYLMPFLEEEKAKN--------GDQRN 413
Query: 2284 QGTVVIATVKGDVHDIGKNIVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSG 2463
G +++ATVKGDVHDIGKNIV VVL CNN+ +VD+GVM P I++ AI EK D IGLSG
Sbjct: 414 AGKILMATVKGDVHDIGKNIVGVVLACNNYDIVDIGVMVPAAKILETAINEKVDIIGLSG 473
Query: 2464 LITPSLDEMVYVAKEMNRVGLNIPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVV 2643
LITPSLDEMV VAKEM R G IPLLIGGATTS+ HTAVKI P Y V+H LDASK V
Sbjct: 474 LITPSLDEMVTVAKEMERAGFKIPLLIGGATTSRIHTAVKIDPNYSGAVIHVLDASKGVP 533
Query: 2644 VCSSLSDMSVRDAFLQDLNEDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVK 2823
V S L +AF++++ +Y +R+++ +D+ + + K+++DW+ V
Sbjct: 534 VASKLLSDDQSEAFVKEMKAEYAQLREDYANKREDKNYVTYKEACANKYQVDWETAKIVT 593
Query: 2824 PSFVGRREYQNFDLNELIPYIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDD 3003
P +G +F L E+ YIDW PFF W L+GK YPKI D +G EA K+F+D
Sbjct: 594 PKQLGNYALNDFSLEEIREYIDWTPFFQTWMLKGK-----YPKILKDPVIGVEATKLFED 648
Query: 3004 AQTWLKKLIDEKILVANAVVSFLPAASEGDD-MHVYDPETGNK-LDTFYGLRQQSGREHD 3177
A L K+I EK L ANA PAA DD + VY ET L F+ LRQQ + D
Sbjct: 649 ANVLLDKVIAEKWLTANAAYGMYPAAVVNDDTVEVYSDETRTTVLKKFHFLRQQGKKGKD 708
Query: 3178 QPHFCLSDFIKPLKNGVPDDYLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLA 3357
P+ L+DFI P ++G DY+G+FA TAG+G E + + EK+HDDY SIM+KA+ADRLA
Sbjct: 709 VPNISLADFIAPKESG-KLDYIGMFAVTAGMGIEPHLERFEKDHDDYNSIMLKAIADRLA 767
Query: 3358 EAYAEYLHKEVRTTLWGYSTNEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLE 3537
EA+AE LH +VR WGY+++E L +L+ Y GIRPA GYP+ PDHTEK L+KLL+
Sbjct: 768 EAFAECLHAKVRKEYWGYASDETLDNEELIKESYIGIRPAPGYPACPDHTEKPDLFKLLD 827
Query: 3538 A-EKNGIGLTEHLAMLPAASVSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVER 3714
A K GI LTE +AM PA+SVSG YFAN ++YF +GK+ +DQV YA+RKN+ +E+
Sbjct: 828 ATNKTGIILTESMAMYPASSVSGFYFANADAKYFGLGKVAKDQVEAYASRKNMNLSTMEK 887
Query: 3715 WLSPILGYD 3741
WL+P L YD
Sbjct: 888 WLAPNLTYD 896
>gi|21242310|ref|NP_641892.1| 5-methyltetrahydrofolate-homocysteine
methyltransferase [Xanthomonas axonopodis pv. citri str.
306]
gi|21107741|gb|AAM36428.1| 5-methyltetrahydrofolate-homocysteine
methyltransferase [Xanthomonas axonopodis pv. citri str.
306]
Length = 917
Score = 914 bits (2362), Expect = 0.0
Identities = 492/925 (53%), Positives = 616/925 (66%), Gaps = 21/925 (2%)
Frame = +1
Query: 1036 LSGLEPSIVGPETNFVNIGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVN 1215
LSGLEP ++ P+ FVN+GER NV GS +F LIK E Y+ A++VAR QVDSGAQILDVN
Sbjct: 9 LSGLEPLVITPDLLFVNVGERTNVTGSAQFRKLIKEERYEEAVEVARQQVDSGAQILDVN 68
Query: 1216 MDDGLLDGPYAMSKFLRLISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKE 1395
MD+GL+D AM++FL LI SEPD+A+IPV +DSS + VI AGL+ QGK VVNSISLKE
Sbjct: 69 MDEGLIDSEKAMTRFLNLIMSEPDIARIPVMVDSSKWSVIEAGLKCLQGKSVVNSISLKE 128
Query: 1396 GEEKFKERARIIKRYGAAVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIF 1575
GE F E AR + RYGAA VVMAFDE GQA K EIC R+Y +LTE+VGF P DIIF
Sbjct: 129 GEAVFIEHARKVLRYGAAAVVMAFDEAGQADTCARKVEICTRAYTLLTEQVGFPPEDIIF 188
Query: 1576 DANILTIATGMEEHSNYGMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHS 1755
D NI +ATG+EEH NY + FIEA R+I++ LP HVSGGVSN+SFSFRG E +R+A+HS
Sbjct: 189 DPNIFAVATGIEEHDNYAVDFIEATRIIKDTLPHCHVSGGVSNVSFSFRGNETVRQAIHS 248
Query: 1756 VFLFYAIKAGMDMGIVNAGALPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEMXXX 1935
VFLF+AIKAGMDMGIVNAG +P+Y+++D NR + TE+LL A+
Sbjct: 249 VFLFHAIKAGMDMGIVNAGGMPIYDELDPELRERVEDVILNRRRDGTERLLEIAERYKGT 308
Query: 1936 XXXXXXXXXEWRSLTVEERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDG 2115
WR V RL ALV G+D FV DTEEARQ++ RPL+VIE PLMDG
Sbjct: 309 KGAAKVEDLAWRDKPVRARLAHALVHGIDAFVETDTEEARQHST---RPLDVIEGPLMDG 365
Query: 2116 MAVVGELFGAGKMFLPQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTV 2295
M VVG+LFGAGKMFLPQV+KSARVMKKAVA+LLPF+E E+ D G +
Sbjct: 366 MNVVGDLFGAGKMFLPQVVKSARVMKKAVAYLLPFIEAEKLR-------TGDVGKSNGKI 418
Query: 2296 VIATVKGDVHDIGKNIVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITP 2475
++ATVKGDVHDIGKNIV VVL CNNF VVDLGVM + I+ A EE AD IGLSGLITP
Sbjct: 419 IMATVKGDVHDIGKNIVGVVLACNNFDVVDLGVMVSAQVILDRAREENADLIGLSGLITP 478
Query: 2476 SLDEMVYVAKEMNRVGLNIPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSS 2655
SL+EM +VA+EM R G +IPLLIGGATTS+ HTA+KI P Y P V DAS++V V S
Sbjct: 479 SLEEMSHVAREMQRQGFDIPLLIGGATTSRAHTALKIDPHYTAPTVWVKDASRAVGVAQS 538
Query: 2656 LSDMSVRDAFLQDLNEDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFV 2835
L +R AF+ + DY ++R H +R L K R ++F DW +T P
Sbjct: 539 LISRDLRQAFVAANDADYAEIRARHRNRGDAKRLVSLEKARAQRFDGDWGTYTPPAPRQP 598
Query: 2836 GRREYQNFDLNELIPYIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTW 3015
G + ++ L ELI IDW PFF W+L GK +P I D VG +A +++ DA+
Sbjct: 599 GIHVFDDYPLQELIELIDWTPFFQAWELAGK-----FPAILSDEIVGTQASELYRDARRM 653
Query: 3016 LKKLIDEKILVANAVVSFLPAASEGDDMHVY--DP-----ETGN-------------KLD 3135
LK++++EK L A AV PA S GDD+ V DP E G+
Sbjct: 654 LKRIVEEKWLTAKAVFGLWPANSVGDDVEVILTDPRDSEVEIGDWQKQSQSRISNPQSRQ 713
Query: 3136 TFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDDYLGLFACTAGLGAEEYCKTLEKNHDD 3315
+ LRQQ + D+P FCL+DFI P +G D++G FA TAG+G + + E HDD
Sbjct: 714 LLHFLRQQVDKPIDRPDFCLADFIAPKSSGT-QDWIGAFAVTAGIGIDAHVARFEAAHDD 772
Query: 3316 YASIMVKALADRLAEAYAEYLHKEVRTTLWGYSTNEDLTESDLLSIKYQGIRPACGYPSQ 3495
Y SI++KALADRLAEA AE LH+ VRT WGY +E L L++ +Y+GIRPA GYP+
Sbjct: 773 YNSILLKALADRLAEALAERLHQRVRTEFWGYVEDEALDNEALIAERYRGIRPAPGYPAC 832
Query: 3496 PDHTEKRTLWKLLEAEKNG-IGLTEHLAMLPAASVSGLYFANPQSEYFAVGKIDQDQVID 3672
P+H+EKRTL+ LL+AE+N + LTE AMLP A+VSG YF++P+S+YF VG++ ++QV D
Sbjct: 833 PEHSEKRTLFDLLDAERNADMSLTESFAMLPTAAVSGYYFSHPKSQYFVVGRLSKEQVAD 892
Query: 3673 YAARKNVPKEEVERWLSPILGYDTD 3747
YA RK + ERWL+ L YD +
Sbjct: 893 YAKRKGITLALAERWLALNLDYDPE 917
>gi|46312303|ref|ZP_00212900.1| COG1410: Methionine synthase I,
cobalamin-binding domain [Burkholderia cepacia R18194]
Length = 905
Score = 910 bits (2353), Expect = 0.0
Identities = 491/912 (53%), Positives = 628/912 (68%), Gaps = 11/912 (1%)
Frame = +1
Query: 1030 MLLSGLEPSIVGPETNFVNIGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILD 1209
M L+GLEP V P T F+N+GER NV GS+ F +I N +D A+ VAR QV++GAQ++D
Sbjct: 6 MRLAGLEPFNVTPGTLFINVGERTNVTGSKAFARMILNGQFDEALAVARQQVENGAQVID 65
Query: 1210 VNMDDGLLDGPYAMSKFLRLISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISL 1389
+NMD+ +LD AM +FL LI+SEPD+A++P+ IDSS ++VI AGL+ QGK +VNSISL
Sbjct: 66 INMDEAMLDSKAAMVRFLNLIASEPDIARVPIMIDSSKWEVIEAGLKCVQGKAIVNSISL 125
Query: 1390 KEGEEKFKERARIIKRYGAAVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDI 1569
KEGE+ F+ A +I+RYGAA VVMAFDE GQA + K EIC RSY L EVGF P DI
Sbjct: 126 KEGEDAFRHHAHLIRRYGAAAVVMAFDETGQADTYERKIEICTRSYNFLVNEVGFPPEDI 185
Query: 1570 IFDANILTIATGMEEHSNYGMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAM 1749
IFD NI IATG+EEH+NY + FIEA R I++NLP A +SGGVSN+SFSFRG + +REA+
Sbjct: 186 IFDPNIFAIATGIEEHNNYAVDFIEATRWIKQNLPHAKISGGVSNVSFSFRGNDPVREAI 245
Query: 1750 HSVFLFYAIKAGMDMGIVNAGALPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEMX 1929
H+VFL++AI+AGMDMGIVNAG L VY D+D NR ++T++LL A +
Sbjct: 246 HTVFLYHAIQAGMDMGIVNAGQLGVYADLDPELRERVEDVILNRRDDSTDRLLEIADKF- 304
Query: 1930 XXXXXXXXXXXEWRSLTVEERLKFALVKGVDQFVVADTEEARQN-TAKYPRPLNVIERPL 2106
EWR+ VE+RL ALV G+ F+V DTEE R A RP+NVIE PL
Sbjct: 305 KAGGAKKEENLEWRNQPVEKRLSHALVHGITNFIVEDTEEVRAKIDAAGGRPINVIEGPL 364
Query: 2107 MDGMAVVGELFGAGKMFLPQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQ 2286
MDGM +VG+LFG GKMFLPQV+KSARVMK+AVAHL+PF+E E++ E G + +
Sbjct: 365 MDGMNIVGDLFGQGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRLLAEAGG----DVRAK 420
Query: 2287 GTVVIATVKGDVHDIGKNIVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGL 2466
G +VIATVKGDVHDIGKNIVSVVL CNNF+VV++GVM PC I+ A E AD IGLSGL
Sbjct: 421 GKIVIATVKGDVHDIGKNIVSVVLQCNNFEVVNMGVMVPCNEILAKAKVEGADIIGLSGL 480
Query: 2467 ITPSLDEMVYVAKEMNRVGL----NIPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASK 2634
ITPSL+EM YVA EM R IPLLIGGATTS+ HTAVKI+P Y PVV+ DAS+
Sbjct: 481 ITPSLEEMAYVASEMQRDDYFRVKKIPLLIGGATTSRVHTAVKIAPHYEGPVVYVPDASR 540
Query: 2635 SVVVCSSLSDMSVRDAFLQDLNEDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFT 2814
SV V SSL +L +L DYE +R +H A+ K + L + R K K+DW +
Sbjct: 541 SVSVASSLLSDEGATKYLDELKSDYERIRDQH-ANRKAQPMVTLAEARANKTKVDWAGYQ 599
Query: 2815 AVKPSFVGRREYQNFDLNELIPYIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKV 2994
VKP F+GRR ++N+DLNEL YIDW PFF W L G YP I +D VG A++V
Sbjct: 600 PVKPKFIGRRVFKNYDLNELAQYIDWGPFFQTWDLAG-----PYPAILNDEIVGESARRV 654
Query: 2995 FDDAQTWLKKLIDEKILVANAVVSFLPAAS-EGDDMHVYDPETGNK-LDTFYGLRQQSGR 3168
F DA++ L +LI + L A+ V+S LPA + GDD+ +Y E+ ++ L T+ LRQQS R
Sbjct: 655 FSDAKSMLARLIQGRWLTASGVISLLPANTVNGDDIEIYSDESRSEVLLTWRNLRQQSVR 714
Query: 3169 E----HDQPHFCLSDFIKPLKNGVPDDYLGLFACTAGLGAEEYCKTLEKNHDDYASIMVK 3336
+P+ L+DFI P ++GV DY+G+FA TAGLG + K E +HDDY++IM+K
Sbjct: 715 PVVDGVMRPNRSLADFIAPKESGVA-DYIGMFAVTAGLGVDVKEKQFEADHDDYSAIMLK 773
Query: 3337 ALADRLAEAYAEYLHKEVRTTLWGYSTNEDLTESDLLSIKYQGIRPACGYPSQPDHTEKR 3516
ALADR AEA+AE +H VR LWGY++ E L L++ KY GIRPA GYP+ PDH KR
Sbjct: 774 ALADRFAEAFAEAMHARVRRELWGYASGETLDNDALIAEKYAGIRPAPGYPACPDHLVKR 833
Query: 3517 TLWKLLEAEKNGIGLTEHLAMLPAASVSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVP 3696
++ +L A++ G+ +T+ LAMLPAASVSG Y A+P S YF+VGKI QDQ+ DYA R +
Sbjct: 834 DMFDVLRADEIGMSVTDSLAMLPAASVSGFYLAHPDSTYFSVGKIGQDQLEDYAQRMALS 893
Query: 3697 KEEVERWLSPIL 3732
++ R L+P L
Sbjct: 894 LDDARRALAPQL 905
>gi|21230966|ref|NP_636883.1| 5-methyltetrahydrofolate-homocysteine
methyltransferase [Xanthomonas campestris pv. campestris
str. ATCC 33913]
gi|21112585|gb|AAM40807.1| 5-methyltetrahydrofolate-homocysteine
methyltransferase [Xanthomonas campestris pv. campestris
str. ATCC 33913]
Length = 918
Score = 910 bits (2352), Expect = 0.0
Identities = 488/925 (52%), Positives = 612/925 (65%), Gaps = 21/925 (2%)
Frame = +1
Query: 1036 LSGLEPSIVGPETNFVNIGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVN 1215
LSGLEP ++ P+ FVN+GER NV GS +F LIK E Y+ A++VAR QV +GAQILDVN
Sbjct: 10 LSGLEPLVITPDLLFVNVGERTNVTGSAQFRKLIKEERYEEAVEVARQQVANGAQILDVN 69
Query: 1216 MDDGLLDGPYAMSKFLRLISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKE 1395
MD+GL+D AM++FL LI SEPD+A+IPV +DSS + VI AGL+ QGK +VNSISLKE
Sbjct: 70 MDEGLIDSEKAMTRFLNLIMSEPDIARIPVMVDSSKWTVIEAGLKCLQGKSIVNSISLKE 129
Query: 1396 GEEKFKERARIIKRYGAAVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIF 1575
GE F E+AR + RYGAA VVMAFDE GQA K EIC R+Y++LTE+VGF P DIIF
Sbjct: 130 GEAVFIEQARKVLRYGAAAVVMAFDEVGQADTCARKVEICTRAYKVLTEKVGFPPEDIIF 189
Query: 1576 DANILTIATGMEEHSNYGMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHS 1755
D NI +ATG+EEH NY + FIEA R I+ LP H+SGGVSN+SFSFRG E++R+A+HS
Sbjct: 190 DPNIFAVATGIEEHDNYAVDFIEATREIKRTLPHCHISGGVSNVSFSFRGNESVRQAIHS 249
Query: 1756 VFLFYAIKAGMDMGIVNAGALPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEMXXX 1935
VFLF+AIKAGMDMGIVNAG +P+Y+++D NR + TE+LL A+
Sbjct: 250 VFLFHAIKAGMDMGIVNAGGMPIYDELDPELRERVEDVILNRRKDGTERLLEIAERYKGT 309
Query: 1936 XXXXXXXXXEWRSLTVEERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDG 2115
WR V RL ALV G+D FV DTEEARQ + RPL+VIE PLMDG
Sbjct: 310 KGAARTEDLAWREKPVRARLAHALVHGIDAFVETDTEEARQLST---RPLDVIEGPLMDG 366
Query: 2116 MAVVGELFGAGKMFLPQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTV 2295
M VVG+LFGAGKMFLPQV+KSARVMKKAVA+LLPF+E E+ D G +
Sbjct: 367 MNVVGDLFGAGKMFLPQVVKSARVMKKAVAYLLPFIEAEKLR-------TGDVGKSNGKI 419
Query: 2296 VIATVKGDVHDIGKNIVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITP 2475
++ATVKGDVHDIGKNIV VVL CNNF VVDLGVM + I+ A EE AD IGLSGLITP
Sbjct: 420 IMATVKGDVHDIGKNIVGVVLACNNFDVVDLGVMVSAQVILDRAREENADLIGLSGLITP 479
Query: 2476 SLDEMVYVAKEMNRVGLNIPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSS 2655
SL+EM +VA+EM R G IPLLIGGATTS+ HTA+KI P Y P V DAS++V V S
Sbjct: 480 SLEEMSHVAREMQRQGFEIPLLIGGATTSRAHTALKIDPHYTAPTVWVKDASRAVGVAQS 539
Query: 2656 LSDMSVRDAFLQDLNEDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFV 2835
L +R AF+ DY ++R H +R L K R +KF WD +T P
Sbjct: 540 LISRDLRQAFVAANEADYAEIRARHRNRGDAKRLVSLEKARAQKFDGGWDSYTPPAPRQP 599
Query: 2836 GRREYQNFDLNELIPYIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTW 3015
G + + ++ L+ELI IDW PFF W+L GK +P I D VG +A +++ DA+
Sbjct: 600 GLQVFDDYPLDELIELIDWTPFFQAWELAGK-----FPAILSDEIVGPQASELYRDARRM 654
Query: 3016 LKKLIDEKILVANAVVSFLPAASEGDDM------------HVYDPETGNKLD-------- 3135
LK++++EK L A AV PA S GDD+ H LD
Sbjct: 655 LKRIVEEKWLTAKAVFGLWPANSVGDDVVVLTEPADSAIPHGESHSAAEALDHSRFSIPH 714
Query: 3136 TFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDDYLGLFACTAGLGAEEYCKTLEKNHDD 3315
+ + LRQQ + D+P FCL+DFI P +G D++G FA TAG+G + + E HDD
Sbjct: 715 SLHFLRQQVDKPVDRPDFCLADFIAPRSSG-KQDWIGAFAVTAGIGIDPHVARFEAAHDD 773
Query: 3316 YASIMVKALADRLAEAYAEYLHKEVRTTLWGYSTNEDLTESDLLSIKYQGIRPACGYPSQ 3495
Y SI++KALADRLAEA AE LH+ VRT WGY +E L L++ +YQGIRPA GYP+
Sbjct: 774 YNSILLKALADRLAEALAERLHQRVRTEFWGYIADETLDNEALIAERYQGIRPAPGYPAC 833
Query: 3496 PDHTEKRTLWKLLEAEKN-GIGLTEHLAMLPAASVSGLYFANPQSEYFAVGKIDQDQVID 3672
P+H+EKRTL+ LL AE+N + LTE AMLP A+VSG YF++P+S+YF VG++ ++QV D
Sbjct: 834 PEHSEKRTLFNLLHAERNAAMSLTESFAMLPTAAVSGYYFSHPKSQYFVVGRLGKEQVAD 893
Query: 3673 YAARKNVPKEEVERWLSPILGYDTD 3747
YA RK + ERWL+ L YD +
Sbjct: 894 YAKRKGITLALAERWLASNLDYDPE 918
>gi|46323648|ref|ZP_00224011.1| COG1410: Methionine synthase I,
cobalamin-binding domain [Burkholderia cepacia R1808]
Length = 905
Score = 909 bits (2349), Expect = 0.0
Identities = 493/912 (54%), Positives = 628/912 (68%), Gaps = 11/912 (1%)
Frame = +1
Query: 1030 MLLSGLEPSIVGPETNFVNIGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILD 1209
M L+GLEP V T F+N+GER NV GS+ F +I N +D A+ VAR QV++GAQ++D
Sbjct: 6 MRLAGLEPFNVTSGTLFINVGERTNVTGSKAFARMILNGQFDEALAVARQQVENGAQVID 65
Query: 1210 VNMDDGLLDGPYAMSKFLRLISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISL 1389
VNMD+ +LD AM +FL LI+SEPD+A++P+ IDSS +DVI AGL+ QGK +VNSISL
Sbjct: 66 VNMDEAMLDSKAAMVRFLNLIASEPDIARVPIMIDSSKWDVIEAGLKCVQGKAIVNSISL 125
Query: 1390 KEGEEKFKERARIIKRYGAAVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDI 1569
KEGE+ F+ A++I+RYGAA VVMAFDE GQA K EIC+RSY L EVGF P DI
Sbjct: 126 KEGEDAFRHHAKLIRRYGAAAVVMAFDETGQADTYQRKTEICKRSYDFLVNEVGFPPEDI 185
Query: 1570 IFDANILTIATGMEEHSNYGMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAM 1749
IFD NI +ATG+EEH+NY + FIEA R I++NLP A VSGGVSN+SFSFRG + +REA+
Sbjct: 186 IFDPNIFAVATGIEEHNNYAVDFIEATRWIKQNLPYAKVSGGVSNVSFSFRGNDPVREAI 245
Query: 1750 HSVFLFYAIKAGMDMGIVNAGALPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEMX 1929
H+VFL++AI+AGMDMGIVNAG L VY D+D NR ++T++LL A +
Sbjct: 246 HTVFLYHAIQAGMDMGIVNAGQLGVYADLDPELRERVEDVILNRRADSTDRLLEIADKF- 304
Query: 1930 XXXXXXXXXXXEWRSLTVEERLKFALVKGVDQFVVADTEEARQN-TAKYPRPLNVIERPL 2106
EWR+ VE+RL ALV G+ F+V DTEEAR A RP+NVIE PL
Sbjct: 305 KTGAAKKEENLEWRNQPVEKRLAHALVHGITNFIVEDTEEARAAIAAAGGRPINVIEGPL 364
Query: 2107 MDGMAVVGELFGAGKMFLPQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQ 2286
MDGM +VG+LFG GKMFLPQV+KSARVMK+AVAHL+PF+E E++ E G + +
Sbjct: 365 MDGMNIVGDLFGQGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRLLAEAGG----DVRAK 420
Query: 2287 GTVVIATVKGDVHDIGKNIVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGL 2466
G +VIATVKGDVHDIGKNIVSVVL CNNF+VV++GVM PC I+ A E AD IGLSGL
Sbjct: 421 GKIVIATVKGDVHDIGKNIVSVVLQCNNFEVVNMGVMVPCNEILAKAKVEGADIIGLSGL 480
Query: 2467 ITPSLDEMVYVAKEMNRVGL----NIPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASK 2634
ITPSL+EM YVA EM R IPLLIGGATTS+ HTAVKI+P Y PVV+ DAS+
Sbjct: 481 ITPSLEEMAYVASEMQRDDYFRVKKIPLLIGGATTSRVHTAVKIAPHYEGPVVYVPDASR 540
Query: 2635 SVVVCSSLSDMSVRDAFLQDLNEDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFT 2814
SV V S+L +L DL DYE +R +H A+ K + L + R K +IDW +
Sbjct: 541 SVSVASNLLSDEGAAKYLDDLKADYERIRDQH-ANRKAQPMVTLAEARANKTRIDWSSYR 599
Query: 2815 AVKPSFVGRREYQNFDLNELIPYIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKV 2994
VKP F+GRR ++N+DLNEL YIDW PFF W L G YP I +D VG A++V
Sbjct: 600 PVKPKFIGRRVFKNYDLNELANYIDWGPFFQTWDLAG-----PYPAILNDEIVGESARRV 654
Query: 2995 FDDAQTWLKKLIDEKILVANAVVSFLPAAS-EGDDMHVYDPETGNK-LDTFYGLRQQSGR 3168
F DA++ L +LI + L AN V+S LPA + DD+ +Y +T ++ L T+ LRQQS R
Sbjct: 655 FSDAKSMLARLIQGRWLTANGVISLLPANTVNDDDIEIYTDDTRSEVLLTWRNLRQQSVR 714
Query: 3169 E----HDQPHFCLSDFIKPLKNGVPDDYLGLFACTAGLGAEEYCKTLEKNHDDYASIMVK 3336
+P+ L+DFI P +GV DY+G+FA TAGLG + K E +HDDY++IM+K
Sbjct: 715 PVVDGVMRPNRSLADFIAPKDSGVA-DYIGMFAVTAGLGVDVKEKQFEADHDDYSAIMLK 773
Query: 3337 ALADRLAEAYAEYLHKEVRTTLWGYSTNEDLTESDLLSIKYQGIRPACGYPSQPDHTEKR 3516
ALADR AEA+AE +H VR LWGY+++E L L++ KY GIRPA GYP+ PDH KR
Sbjct: 774 ALADRFAEAFAEAMHARVRRELWGYASDETLDNDALIAEKYAGIRPAPGYPACPDHLVKR 833
Query: 3517 TLWKLLEAEKNGIGLTEHLAMLPAASVSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVP 3696
++ L A++ G+ +T+ LAMLPAASVSG Y A+P S YF+VGKI QDQ+ DYA R ++
Sbjct: 834 DMFAALHADEIGMSVTDSLAMLPAASVSGFYLAHPDSRYFSVGKIGQDQLDDYARRMSLS 893
Query: 3697 KEEVERWLSPIL 3732
++ R L+P L
Sbjct: 894 LDDARRALAPQL 905
>gi|17545013|ref|NP_518415.1| PROBABLE
5-METHYLTETRAHYDROFOLATE--HOMOCYSTEINE METHYLTRANSFERASE
(METHIONINE SYNTHASE, VITAMIN-B12 DEPENDENT ISOZYME)
PROTEIN [Ralstonia solanacearum GMI1000]
gi|17427303|emb|CAD13822.1| PROBABLE
5-METHYLTETRAHYDROFOLATE--HOMOCYSTEINE METHYLTRANSFERASE
(METHIONINE SYNTHASE, VITAMIN-B12 DEPENDENT ISOZYME)
PROTEIN [Ralstonia solanacearum]
Length = 905
Score = 909 bits (2348), Expect = 0.0
Identities = 490/912 (53%), Positives = 628/912 (68%), Gaps = 11/912 (1%)
Frame = +1
Query: 1030 MLLSGLEPSIVGPETNFVNIGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILD 1209
M LSGLEP +G +T FVN+GER NV GS+ F +I N +D A+ VAR QV++GAQ++D
Sbjct: 6 MRLSGLEPFNIGEDTLFVNVGERTNVTGSKAFARMILNSQFDEALAVARQQVENGAQVID 65
Query: 1210 VNMDDGLLDGPYAMSKFLRLISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISL 1389
+NMD+ +LD AM +FL LI+SEPD+A++P+ IDSS ++VI AGL+ QGK +VNSISL
Sbjct: 66 INMDEAMLDSKAAMVRFLNLIASEPDIARVPIMIDSSKWEVIEAGLKCVQGKAIVNSISL 125
Query: 1390 KEGEEKFKERARIIKRYGAAVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDI 1569
KEGEE+F A++IKRYGAA VVMAFDEQGQA K EIC+RSY L +VGF P DI
Sbjct: 126 KEGEEQFAHHAKLIKRYGAAAVVMAFDEQGQADTFARKTEICKRSYDFLVNQVGFAPEDI 185
Query: 1570 IFDANILTIATGMEEHSNYGMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAM 1749
IFD NI +ATG+EEH+NY + FIEA R I++ LP A VSGGVSN+SFSFRG + +REA+
Sbjct: 186 IFDPNIFAVATGIEEHNNYAVDFIEATRWIKQKLPHAKVSGGVSNVSFSFRGNDVVREAI 245
Query: 1750 HSVFLFYAIKAGMDMGIVNAGALPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEMX 1929
H+VFL++AI AGMDMGIVNAG L VYE++ NR P+AT++LL A +
Sbjct: 246 HTVFLYHAIGAGMDMGIVNAGQLGVYENLAPELRERVEDVVLNRRPDATDRLLEIA-DRY 304
Query: 1930 XXXXXXXXXXXEWRSLTVEERLKFALVKGVDQFVVADTEEARQNT-AKYPRPLNVIERPL 2106
WR VE+RL ALV G+ +VV DTEE RQ A RP+ VIE PL
Sbjct: 305 KGGGAKREENLAWRQEPVEKRLAHALVHGITDYVVEDTEEVRQKIFAAGGRPIQVIEGPL 364
Query: 2107 MDGMAVVGELFGAGKMFLPQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQ 2286
MDGM +VG+LFGAGKMFLPQV+KSARVMK+AVAHL+PF+E E++ + A + +
Sbjct: 365 MDGMNIVGDLFGAGKMFLPQVVKSARVMKQAVAHLIPFIEEEKR----QIAAAGGDVRSR 420
Query: 2287 GTVVIATVKGDVHDIGKNIVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGL 2466
G +VIATVKGDVHDIGKNIV+VVL CNNF+VV++GVM PC I+ A E AD IGLSGL
Sbjct: 421 GKIVIATVKGDVHDIGKNIVTVVLQCNNFEVVNMGVMVPCNEILAKAKVEGADIIGLSGL 480
Query: 2467 ITPSLDEMVYVAKEMNRVGL----NIPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASK 2634
ITPSL+EM YVA EM R IPLLIGGATTS+ HTAVKI+P Y PVV+ DAS+
Sbjct: 481 ITPSLEEMAYVASEMQRDEYFRVKKIPLLIGGATTSRVHTAVKIAPNYEGPVVYVPDASR 540
Query: 2635 SVVVCSSLSDMSVRDAFLQDLNEDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFT 2814
SV V SSL ++++L+ DY+ +R +H AS K L R K +IDW +T
Sbjct: 541 SVSVASSLLSDEAAARYIEELHADYDRIRTQH-ASKKAMPMVSLAAARANKTRIDWSNYT 599
Query: 2815 AVKPSFVGRREYQNFDLNELIPYIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKV 2994
KP FVGRR ++N+DLNEL YIDW PFF W L GK+P+ I +DA VG A++V
Sbjct: 600 PPKPKFVGRRVFRNYDLNELAQYIDWGPFFQTWDLAGKFPD-----ILNDAIVGESARRV 654
Query: 2995 FDDAQTWLKKLIDEKILVANAVVSFLPAAS-EGDDMHVYDPETGNKLD-TFYGLRQQSGR 3168
F D ++ L +LI + L AN V++ LPA + DD+ +Y ET +++ T+ +RQQS R
Sbjct: 655 FSDGKSMLARLIAGRWLTANGVIALLPANTVNDDDIEIYTDETRSEVALTWRNIRQQSER 714
Query: 3169 E----HDQPHFCLSDFIKPLKNGVPDDYLGLFACTAGLGAEEYCKTLEKNHDDYASIMVK 3336
+P+ CL+DFI P G+ DY+GLFA T G+G ++ E +HDDY++IM+K
Sbjct: 715 PIIDGVMRPNRCLADFIAPKDTGIA-DYIGLFAVTGGIGIDKREAAFEADHDDYSAIMLK 773
Query: 3337 ALADRLAEAYAEYLHKEVRTTLWGYSTNEDLTESDLLSIKYQGIRPACGYPSQPDHTEKR 3516
ALADR AEA+AE LH VR LWGY+ +E L L+ +Y+GIRPA GYP+ P+HT KR
Sbjct: 774 ALADRFAEAFAECLHARVRRDLWGYAQDETLDNDALIREEYRGIRPAPGYPACPEHTVKR 833
Query: 3517 TLWKLLEAEKNGIGLTEHLAMLPAASVSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVP 3696
L+++L+A++ G+ LTE LAM PAASVSG ++P S YF +GKI QDQV D AAR
Sbjct: 834 DLFRVLDAQEIGMNLTEALAMTPAASVSGFQLSHPDSTYFTIGKIGQDQVDDMAARSGED 893
Query: 3697 KEEVERWLSPIL 3732
+ VER L+P L
Sbjct: 894 RRNVERALAPNL 905
>gi|48786383|ref|ZP_00282517.1| COG1410: Methionine synthase I,
cobalamin-binding domain [Burkholderia fungorum LB400]
Length = 905
Score = 906 bits (2342), Expect = 0.0
Identities = 490/910 (53%), Positives = 629/910 (68%), Gaps = 11/910 (1%)
Frame = +1
Query: 1036 LSGLEPSIVGPETNFVNIGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVN 1215
L+GLEP V T F+N+GER NV GS+ F +I N+ +D AI VAR QV++GAQI+DVN
Sbjct: 8 LAGLEPFNVTSGTLFINVGERTNVTGSKAFARMILNDQFDDAIAVARQQVENGAQIIDVN 67
Query: 1216 MDDGLLDGPYAMSKFLRLISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKE 1395
MD+ +LD AM +F+ LI+SEPD+A++P+ IDSS ++VI AGL+ QGK +VNSISLKE
Sbjct: 68 MDEAMLDSKAAMVRFMNLIASEPDIARVPIMIDSSKWEVIEAGLKCVQGKAIVNSISLKE 127
Query: 1396 GEEKFKERARIIKRYGAAVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIF 1575
GEE F+ A +I+RYGAA VVMAFDEQGQA + K +IC+RSY L EVGF P DIIF
Sbjct: 128 GEEAFRHHANLIRRYGAAAVVMAFDEQGQADTFERKTQICKRSYDFLVNEVGFPPEDIIF 187
Query: 1576 DANILTIATGMEEHSNYGMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHS 1755
D NI IATG+EEH+NY + FI A R I++NLP A VSGGVSN+SFSFRG + +REA+H+
Sbjct: 188 DPNIFAIATGIEEHNNYAVDFINATRWIKQNLPYAKVSGGVSNVSFSFRGNDPVREAIHT 247
Query: 1756 VFLFYAIKAGMDMGIVNAGALPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEMXXX 1935
VFL++AI+AGMDMGIVNAG L VY D+D NR + T++LL A +
Sbjct: 248 VFLYHAIQAGMDMGIVNAGQLGVYADLDPELRERVEDVVLNRREDGTDRLLEIADKF-KT 306
Query: 1936 XXXXXXXXXEWRSLTVEERLKFALVKGVDQFVVADTEEARQN-TAKYPRPLNVIERPLMD 2112
EWR+ VE+RL ALV G+ F+V DTEE R A+ RP+NVIE PLMD
Sbjct: 307 GAAKKEENLEWRNQPVEKRLSHALVHGITNFIVEDTEEVRAKIAAEGGRPINVIEGPLMD 366
Query: 2113 GMAVVGELFGAGKMFLPQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGT 2292
GM +VG+LFG GKMFLPQV+KSARVMK+AVAHL+P++E E++ E A + +G
Sbjct: 367 GMNIVGDLFGQGKMFLPQVVKSARVMKQAVAHLIPYIEEEKKQLAE----AGADVRAKGK 422
Query: 2293 VVIATVKGDVHDIGKNIVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLIT 2472
+VIATVKGDVHDIGKNIVSVVL CNNF+VV++GVM C +I+ A E AD IGLSGLIT
Sbjct: 423 IVIATVKGDVHDIGKNIVSVVLQCNNFEVVNMGVMVSCNDILAKAKVEGADIIGLSGLIT 482
Query: 2473 PSLDEMVYVAKEMNRVGL----NIPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSV 2640
PSL+EM YVA EM R IPLLIGGATTS+ HTAVKI+P Y PVV+ DAS+SV
Sbjct: 483 PSLEEMAYVASEMQRDDYFRIKKIPLLIGGATTSRVHTAVKIAPHYEGPVVYVPDASRSV 542
Query: 2641 VVCSSLSDMSVRDAFLQDLNEDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAV 2820
V SSL +L +L DY+ +R +H A+ K L + R K ++DW + V
Sbjct: 543 SVASSLLSDEGAAKYLDELKSDYDRIRDQH-ANKKALPMVTLAEARANKTRVDWASYQPV 601
Query: 2821 KPSFVGRREYQNFDLNELIPYIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFD 3000
KP F+GRR ++NFDL EL YIDW PFF W L G YP I +D VG A++VF
Sbjct: 602 KPKFIGRRVFRNFDLAELATYIDWGPFFQTWDLAG-----PYPAILNDEIVGESARRVFS 656
Query: 3001 DAQTWLKKLIDEKILVANAVVSFLPAAS-EGDDMHVYDPETGNKLD-TFYGLRQQSGRE- 3171
D ++ L +LI + L AN V++ LPA + DD+ +Y E+ +++ T+ LRQQS R
Sbjct: 657 DGKSMLARLIQGRWLQANGVIALLPANTVNDDDIEIYTDESRSEVALTWRNLRQQSVRPV 716
Query: 3172 ---HDQPHFCLSDFIKPLKNGVPDDYLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKAL 3342
+P+ L+DFI P +GV DY+G+FA TAGLG + K EK+HDDY++IM+KAL
Sbjct: 717 VDGVMRPNRSLADFIAPKDSGVA-DYIGMFAVTAGLGVDVKEKQFEKDHDDYSAIMLKAL 775
Query: 3343 ADRLAEAYAEYLHKEVRTTLWGYSTNEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTL 3522
ADR AEA+AE LH VR LWGY+ +E L+ +L++ KY+GIRPA GYP+ PDH KR +
Sbjct: 776 ADRFAEAFAEALHARVRRDLWGYANDETLSTDELIAEKYRGIRPAPGYPACPDHLVKRDM 835
Query: 3523 WKLLEAEKNGIGLTEHLAMLPAASVSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKE 3702
+ +L A + G+ +TE LAMLPAASVSG Y A+P S YF+VGKI QDQ+ DYA R ++ K
Sbjct: 836 FNVLHATEIGMSVTESLAMLPAASVSGFYLAHPDSTYFSVGKIGQDQLEDYARRMSLSKT 895
Query: 3703 EVERWLSPIL 3732
+ ER L+P+L
Sbjct: 896 DAERALAPLL 905
>gi|45515898|ref|ZP_00167452.1| COG1410: Methionine synthase I,
cobalamin-binding domain [Ralstonia eutropha JMP134]
Length = 915
Score = 905 bits (2338), Expect = 0.0
Identities = 495/930 (53%), Positives = 634/930 (67%), Gaps = 16/930 (1%)
Frame = +1
Query: 991 TPRVPPQDPHAGKMLLSGLEPSIVGPETNFVNIGERCNVAGSRRFCNLIKNENYDTAIDV 1170
T ++PP+ M LSGLEP + +T FVN+GER NV GS+ F +I N +D A+ V
Sbjct: 3 TNQLPPRP-----MRLSGLEPFTIDDDTLFVNVGERTNVTGSKAFARMILNGQFDEALAV 57
Query: 1171 ARVQVDSGAQILDVNMDDGLLDGPYAMSKFLRLISSEPDVAKIPVCIDSSDFDVIIAGLE 1350
AR QV++GAQI+D+NMD+ +LD AM +FL LI+SEPD+A++P+ IDSS ++VI AGL+
Sbjct: 58 ARQQVENGAQIIDINMDEAMLDSKAAMVRFLNLIASEPDIARVPIMIDSSKWEVIEAGLQ 117
Query: 1351 STQGKCVVNSISLKEGEEKFKERARIIKRYGAAVVVMAFDEQGQAAETDPKFEICERSYR 1530
QGK VVNSISLKEGEE+F+ A +I+RYGAA VVMAFDE+GQA + K IC+RSY
Sbjct: 118 CVQGKPVVNSISLKEGEEQFRHHAELIRRYGAATVVMAFDEKGQADTFERKTAICKRSYD 177
Query: 1531 ILTEEVGFNPNDIIFDANILTIATGMEEHSNYGMYFIEAARMIRENLPGAHVSGGVSNIS 1710
L EVGF P DIIFD NI +ATG+EEH+NY + FIEA R I++NLP A VSGGVSN+S
Sbjct: 178 FLVNEVGFPPEDIIFDPNIFAVATGIEEHNNYAVDFIEATRWIKQNLPYAKVSGGVSNVS 237
Query: 1711 FSFRGMEAIREAMHSVFLFYAIKAGMDMGIVNAGALPVYEDIDKPXXXXXXXXXFNRDPE 1890
FSFRG + +REA+H+VFLF+AI+AGMDMGIVNAG L VY+ +D NR +
Sbjct: 238 FSFRGNDLVREAIHTVFLFHAIEAGMDMGIVNAGQLGVYDQLDPELRERVEDVVLNRRDD 297
Query: 1891 ATEKLLVAAQEMXXXXXXXXXXXXEWRS-----LTVEERLKFALVKGVDQFVVADTEEAR 2055
AT++LL A + WR + V +RL ALV G+ F+V DTEEAR
Sbjct: 298 ATDRLLEIADKFKGGGAKKEENLA-WRGTPEQPVPVAKRLAHALVHGITNFIVDDTEEAR 356
Query: 2056 QN-TAKYPRPLNVIERPLMDGMAVVGELFGAGKMFLPQVIKSARVMKKAVAHLLPFMEIE 2232
Q A+ RP+ VIE PLMDGM VVG+LFGAGKMFLPQV+KSARVMK+AVAHLLPF+E E
Sbjct: 357 QEIAARGGRPIEVIEGPLMDGMNVVGDLFGAGKMFLPQVVKSARVMKQAVAHLLPFIEEE 416
Query: 2233 RQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKNIVSVVLGCNNFKVVDLGVMTPCEN 2412
++ + A + +G +VIATVKGDVHDIGKNIVSVVL CNNF+VV++GVM PC
Sbjct: 417 KR----LLAQAGGDVRSRGKIVIATVKGDVHDIGKNIVSVVLQCNNFEVVNMGVMVPCNE 472
Query: 2413 IIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRVGL----NIPLLIGGATTSKTHTAV 2580
I+ A E AD +GLSGLITPSL+EM YVA EM R IPLLIGGATTS+ HTAV
Sbjct: 473 ILAKAKVEGADIVGLSGLITPSLEEMAYVASEMQRDDYFRVKKIPLLIGGATTSRVHTAV 532
Query: 2581 KISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLNEDYEDVRQEHYASLKDRRFT 2760
KI+P Y PVV+ DAS+SV V SSL +L DL DYE +R +H A K
Sbjct: 533 KIAPNYEGPVVYVPDASRSVSVASSLLSDEGAAKYLDDLKTDYERIRVQH-AGKKATPMV 591
Query: 2761 DLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIPYIDWKPFFDVWQLRGKYPNR 2940
L + R K IDW + KP F+GRR ++N+DL EL +IDW PFF W L GK+P+
Sbjct: 592 TLAQARANKTPIDWSGYVPPKPKFIGRRVFRNYDLAELANFIDWGPFFQTWDLAGKFPD- 650
Query: 2941 SYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAVVSFLPAAS-EGDDMHVYDPE 3117
I +D VG A++VF D + L +LI + L AN V++ LPA + DD+ +Y E
Sbjct: 651 ----ILNDEIVGESARRVFSDGKAMLSRLIQGRWLTANGVMALLPANTVNDDDIEIYTDE 706
Query: 3118 TGNKLD-TFYGLRQQSGRE----HDQPHFCLSDFIKPLKNGVPDDYLGLFACTAGLGAEE 3282
T +K+ T++ +RQQS R +P+ CLSDFI P +GV DY+GLFA TAG+G ++
Sbjct: 707 TRSKVALTWHNVRQQSERPVVDGVRRPNRCLSDFIAPKSSGVA-DYIGLFAVTAGIGVDK 765
Query: 3283 YCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYSTNEDLTESDLLSIKYQ 3462
E +HDDY++IM+KALADR AEA+AE LH+ VRT LWGY E L+ +L++ KY+
Sbjct: 766 KEAQFEADHDDYSAIMLKALADRFAEAFAECLHQRVRTDLWGYDAAEHLSNDELIAEKYR 825
Query: 3463 GIRPACGYPSQPDHTEKRTLWKLLEAEKNGIGLTEHLAMLPAASVSGLYFANPQSEYFAV 3642
GIRPA GYP+ P+HT K +++ L+ + G+G+TE LAM PAASVSG Y ++P S YF +
Sbjct: 826 GIRPAPGYPACPEHTVKGPMFEYLDCAEIGMGITEALAMTPAASVSGFYLSHPDSTYFTI 885
Query: 3643 GKIDQDQVIDYAARKNVPKEEVERWLSPIL 3732
GKI QDQV D AAR++ + V R L+P L
Sbjct: 886 GKIGQDQVDDMAARRHEDRNAVARALAPNL 915
>gi|22957858|ref|ZP_00005544.1| COG1410: Methionine synthase I,
cobalamin-binding domain [Rhodobacter sphaeroides]
Length = 908
Score = 894 bits (2309), Expect = 0.0
Identities = 485/911 (53%), Positives = 613/911 (67%), Gaps = 7/911 (0%)
Frame = +1
Query: 1036 LSGLEPSIVGPETNFVNIGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVN 1215
LSGLEP ++ P+ FVN+GER NV GS RF LI N +Y A++VAR QV +GAQILDVN
Sbjct: 7 LSGLEPFVLTPDIPFVNVGERTNVTGSARFRKLITNRDYAAALEVARDQVQNGAQILDVN 66
Query: 1216 MDDGLLDGPYAMSKFLRLISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKE 1395
MD+GL+D AM +FL LI+SEPD+A++P+ IDSS ++VI AGL+ QGK VVNSISLKE
Sbjct: 67 MDEGLIDSKAAMVEFLNLIASEPDIARVPLMIDSSKWEVIEAGLKCVQGKPVVNSISLKE 126
Query: 1396 GEEKFKERARIIKRYGAAVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIF 1575
GEE F+ +A + YGAAVVVMAFDE+GQA K IC R+YRIL EEVGF P DIIF
Sbjct: 127 GEESFRRQAGLCLAYGAAVVVMAFDEEGQADSFARKTTICARAYRILVEEVGFPPEDIIF 186
Query: 1576 DANILTIATGMEEHSNYGMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHS 1755
D N+ +ATG+EEH NYG+ FIEAAR IR NLP AHVSGGVSN+SFSFRG E +REAMH+
Sbjct: 187 DPNVFAVATGIEEHDNYGVDFIEAARWIRANLPHAHVSGGVSNLSFSFRGNEPVREAMHA 246
Query: 1756 VFLFYAIKAGMDMGIVNAGALPVYEDIDKPXXXXXXXXXFNRDPE----ATEKLLVAAQE 1923
VFL++AI+AGMDMGIVNAG L VY+ ID NR P+ ATE+LL A+
Sbjct: 247 VFLYHAIRAGMDMGIVNAGQLAVYDQIDPDLREACEDVVLNRKPKQGGTATERLLALAER 306
Query: 1924 MXXXXXXXXXXXXEWRSLTVEERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERP 2103
WR VE+RL+ ALV G+ +F+ ADTEEARQ RPL+VIE P
Sbjct: 307 FRGGAREEKTRDLAWRGWPVEKRLEHALVNGITEFIEADTEEARQAA---ERPLHVIEGP 363
Query: 2104 LMDGMAVVGELFGAGKMFLPQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPY 2283
LM GM VVG+LFGAGKMFLPQV+KSARVMK+AVA LLP+ME E++ +G E
Sbjct: 364 LMAGMNVVGDLFGAGKMFLPQVVKSARVMKQAVAVLLPYMEEEKR-----LGGGEGREA- 417
Query: 2284 QGTVVIATVKGDVHDIGKNIVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSG 2463
G V++ATVKGDVHDIGKNIV VVL CNN++++DLGVM P I++ A EK D IGLSG
Sbjct: 418 AGKVLMATVKGDVHDIGKNIVGVVLACNNYEIIDLGVMVPPAKILEVARAEKVDAIGLSG 477
Query: 2464 LITPSLDEMVYVAKEMNRVGLNIPLLIGGATTSKTHTAVKISPRYPH-PVVHCLDASKSV 2640
LITPSLDEMV VA EM R G +IPLLIGGATTSK HTAVKI+P Y P V+ DAS++V
Sbjct: 478 LITPSLDEMVTVAAEMEREGFDIPLLIGGATTSKVHTAVKIAPSYCRGPAVYVTDASRAV 537
Query: 2641 VVCSSLSDMSVRDAFLQDLNEDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAV 2820
V L + A+++ L DY +V + H S + ++ L R K+DW V
Sbjct: 538 GVVGQLLSAERKGAYVEGLRADYAEVAERHARSERAKQRLPLAAARANALKLDWAAHRPV 597
Query: 2821 KPSFVGRREYQNFDLNELIPYIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFD 3000
+PSF G R +DL E+ YIDW FF W+L+G YP+I +D G A+ +F
Sbjct: 598 RPSFTGSRTVDGWDLAEIARYIDWTMFFQTWELKG-----VYPRILEDPAQGEAARALFA 652
Query: 3001 DAQTWLKKLIDEKILVANAVVSFLPAASEGDDMHVYDPETGN-KLDTFYGLRQQSGREHD 3177
DAQ L +++ E+ AVV F PA + GDD+ +Y ET +L TF+ LRQQ +
Sbjct: 653 DAQEMLARIVAERWFTPRAVVGFWPANAVGDDIRLYADETRQAELATFFTLRQQVTKREG 712
Query: 3178 QPHFCLSDFIKPLKNGVPDDYLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLA 3357
+P+ LSDF+ P G D++G F TAG + ++ +D+Y++IMVKALADR A
Sbjct: 713 RPNLALSDFVAP--EGAGPDWVGGFVVTAGPEEASIAERFDRANDNYSAIMVKALADRFA 770
Query: 3358 EAYAEYLHKEVRTTLWGYSTNEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLE 3537
EA AE LH+ VR LWGY+ +E T L + Y+GIRPA GYP+QPDHTEK TL++LL+
Sbjct: 771 EAMAERLHERVRRELWGYAPDESFTPDALHAEPYRGIRPAPGYPAQPDHTEKVTLFRLLD 830
Query: 3538 A-EKNGIGLTEHLAMLPAASVSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVER 3714
A G+ LTE +AM P +SVSGLY +P + YF + ++++DQ DYA RK + EVER
Sbjct: 831 ATAATGVELTESMAMWPGSSVSGLYIGHPDAYYFGLARVERDQAEDYARRKGMELAEVER 890
Query: 3715 WLSPILGYDTD 3747
WL+P++ D
Sbjct: 891 WLAPVMAGRVD 901
>gi|48770516|ref|ZP_00274859.1| COG1410: Methionine synthase I,
cobalamin-binding domain [Ralstonia metallidurans CH34]
Length = 915
Score = 894 bits (2309), Expect = 0.0
Identities = 487/917 (53%), Positives = 622/917 (67%), Gaps = 16/917 (1%)
Frame = +1
Query: 1030 MLLSGLEPSIVGPETNFVNIGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILD 1209
M LSGLEP + +T FVN+GER NV GS+ F +I N +D A+ VAR QV++GAQI+D
Sbjct: 11 MRLSGLEPFTIDDDTLFVNVGERTNVTGSKAFARMILNGQFDEALAVARQQVENGAQIID 70
Query: 1210 VNMDDGLLDGPYAMSKFLRLISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISL 1389
+NMD+ +LD AM +FL LI+SEPD+A++P+ IDSS +DVI AGL QGK VVNSISL
Sbjct: 71 INMDEAMLDSKAAMVRFLNLIASEPDIARVPIMIDSSKWDVIEAGLRCVQGKAVVNSISL 130
Query: 1390 KEGEEKFKERARIIKRYGAAVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDI 1569
KEGEE+F+ A I+RYGAA VVMAFDE+GQA + K EIC+RSY L EVGF P DI
Sbjct: 131 KEGEEQFRHHATQIRRYGAASVVMAFDEKGQADTFERKTEICKRSYDFLVNEVGFPPEDI 190
Query: 1570 IFDANILTIATGMEEHSNYGMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAM 1749
IFD NI +ATG+EEH+NY + FIEA R I++NLP A VSGGVSN+SFSFRG + +REA+
Sbjct: 191 IFDPNIFAVATGIEEHNNYAVDFIEATRWIKQNLPYAKVSGGVSNVSFSFRGNDVVREAI 250
Query: 1750 HSVFLFYAIKAGMDMGIVNAGALPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEMX 1929
H+VFL++AI AGMDMGIVNAG L VY+ +D NR +AT++LL A
Sbjct: 251 HTVFLYHAIAAGMDMGIVNAGQLGVYDQLDPELRERVEDVVLNRRDDATDRLLEIADRFK 310
Query: 1930 XXXXXXXXXXXEWRS-----LTVEERLKFALVKGVDQFVVADTEEARQN-TAKYPRPLNV 2091
WR + V +RL ALV G+ F+V DTEE RQ A+ RP+ V
Sbjct: 311 GGGTKREENLA-WRGTPEQPVPVGDRLAHALVHGITTFIVEDTEEVRQQIAARGGRPIEV 369
Query: 2092 IERPLMDGMAVVGELFGAGKMFLPQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAED 2271
IE PLMDGM +VG+LFGAGKMFLPQV+KSARVMK+AVAHLLPF+E E++ E G
Sbjct: 370 IEGPLMDGMNIVGDLFGAGKMFLPQVVKSARVMKQAVAHLLPFIEEEKRLVAEAGG---- 425
Query: 2272 ESPYQGTVVIATVKGDVHDIGKNIVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFI 2451
+ +G +VIATVKGDVHDIGKNIVSVVL CNNF+VV++GVM PC I+ A E AD +
Sbjct: 426 DVRARGKIVIATVKGDVHDIGKNIVSVVLQCNNFEVVNMGVMVPCNEILARAKVEGADIV 485
Query: 2452 GLSGLITPSLDEMVYVAKEMNRVGL----NIPLLIGGATTSKTHTAVKISPRYPHPVVHC 2619
GLSGLITPSL+EM YVA EM R IPLLIGGATTS+ HTAVKI+P Y PVV+
Sbjct: 486 GLSGLITPSLEEMAYVASEMQRDDYFRVKKIPLLIGGATTSRVHTAVKIAPNYEGPVVYV 545
Query: 2620 LDASKSVVVCSSLSDMSVRDAFLQDLNEDYEDVRQEHYASLKDRRFTDLNKTREKKFKID 2799
DAS+SV V S+L +L +L DY+ +R +H A+ K L + R K ID
Sbjct: 546 PDASRSVSVASNLLSDEGAAKYLDELKSDYDRIRTQH-ANKKATPMVSLAQARANKTPID 604
Query: 2800 WDKFTAVKPSFVGRREYQNFDLNELIPYIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGA 2979
W + KP F+GRR ++N+DL+EL YIDW PFF W L GK+P+ I +D VG
Sbjct: 605 WSAYVPPKPKFIGRRVFRNYDLSELANYIDWGPFFQTWDLAGKFPD-----ILNDEIVGE 659
Query: 2980 EAKKVFDDAQTWLKKLIDEKILVANAVVSFLPAAS-EGDDMHVYDPETGNKLD-TFYGLR 3153
A++VF D ++ L +LI + L AN V++ LPA + DD+ +Y E+ +K+ T+ LR
Sbjct: 660 SARRVFSDGKSMLARLIQGRWLTANGVMALLPANTVNDDDVEIYTDESRSKVALTWNNLR 719
Query: 3154 QQSGRE----HDQPHFCLSDFIKPLKNGVPDDYLGLFACTAGLGAEEYCKTLEKNHDDYA 3321
QQS R +P+ CL+DFI P +GV DY+GLFA TAG+G ++ E +HDDY+
Sbjct: 720 QQSERPVVDGVRRPNRCLADFIAPKSSGVA-DYIGLFAVTAGIGVDKKEAQFEADHDDYS 778
Query: 3322 SIMVKALADRLAEAYAEYLHKEVRTTLWGYSTNEDLTESDLLSIKYQGIRPACGYPSQPD 3501
+IM+KALADRLAEA+AE LH+ VR LWGY E L L++ Y+GIRPA GYP+ P+
Sbjct: 779 AIMLKALADRLAEAFAECLHERVRKDLWGYDAAESLNNDQLVAEAYRGIRPAPGYPACPE 838
Query: 3502 HTEKRTLWKLLEAEKNGIGLTEHLAMLPAASVSGLYFANPQSEYFAVGKIDQDQVIDYAA 3681
HT K ++ L+A G+G+TE LAM PAASVSG Y ++P S YF++GKI QDQ+ D A
Sbjct: 839 HTVKAPMFAFLDAADIGMGITEGLAMTPAASVSGFYLSHPDSTYFSIGKIGQDQLDDMVA 898
Query: 3682 RKNVPKEEVERWLSPIL 3732
R+ + +ER L+P L
Sbjct: 899 RRGEDRLTLERALAPNL 915
>gi|47574009|ref|ZP_00244046.1| COG1410: Methionine synthase I,
cobalamin-binding domain [Rubrivivax gelatinosus PM1]
Length = 909
Score = 880 bits (2275), Expect = 0.0
Identities = 476/920 (51%), Positives = 630/920 (67%), Gaps = 19/920 (2%)
Frame = +1
Query: 1030 MLLSGLEPSIVGPETNFVNIGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILD 1209
M LSGLEP +G + FVNIGER NV GS+ F +I ++ A+ VAR QV++GAQ++D
Sbjct: 1 MRLSGLEPVAIGERSLFVNIGERTNVTGSKAFARMILGGQFEEALAVARQQVENGAQVID 60
Query: 1210 VNMDDGLLDGPYAMSKFLRLISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISL 1389
+NMD+ +LD AM +FL+LI+SEP++A++P+ IDSS ++VI AGL+ QGK +VNSIS+
Sbjct: 61 INMDEAMLDSKAAMERFLKLIASEPEIARVPIMIDSSKWEVIEAGLKCIQGKGIVNSISM 120
Query: 1390 KEGEEKFKERARIIKRYGAAVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDI 1569
KEGE+ F+ +A++++RYGAA VVMAFDEQGQA K EICER+YRIL +EVGF P DI
Sbjct: 121 KEGEDAFRHQAKLVRRYGAAAVVMAFDEQGQADTFARKIEICERAYRILVDEVGFAPEDI 180
Query: 1570 IFDANILTIATGMEEHSNYGMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAM 1749
IFD NI IATG+EEH NY + FIEA R I+++LPGA VSGGVSN+SFSFRG E +REA+
Sbjct: 181 IFDPNIFAIATGIEEHDNYAVDFIEATRWIKQHLPGAKVSGGVSNVSFSFRGNEPVREAI 240
Query: 1750 HSVFLFYAIKAGMDMGIVNAGALPVYEDIDKPXXXXXXXXXFNRDPE--------ATEKL 1905
H+VFL++AI+AGMDMGIVNAG + VY+D+D NR P + +
Sbjct: 241 HTVFLYHAIQAGMDMGIVNAGMVGVYDDLDAELRERVEDVVLNRKPAYKPGEAQLSPGER 300
Query: 1906 LVAAQEMXXXXXXXXXXXXEWRSLTVEERLKFALVKGVDQFVVADTEEARQN-TAKYPRP 2082
L+ E WR+ TV ERL AL+ G+ F+V DTEEA Q A RP
Sbjct: 301 LIEIAERAKGAAKDDSTRLAWRAGTVNERLSHALIHGITDFIVVDTEEAWQAIRADGGRP 360
Query: 2083 LNVIERPLMDGMAVVGELFGAGKMFLPQVIKSARVMKKAVAHLLPFMEIERQANIETMGL 2262
L+VIE PLM GM VVG+LFG GKMFLPQV+KSARVMK+AVAHLLP++E E++A I+ G
Sbjct: 361 LHVIEGPLMAGMNVVGDLFGQGKMFLPQVVKSARVMKQAVAHLLPYIEEEKKALIDAGG- 419
Query: 2263 AEDESPYQGTVVIATVKGDVHDIGKNIVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKA 2442
E+ +G VVIATVKGDVHDIGKNIV+VVL CNNF+VV++GVM C++I+ A E A
Sbjct: 420 ---EAKAKGKVVIATVKGDVHDIGKNIVTVVLQCNNFEVVNMGVMVACQDILAKAKVEGA 476
Query: 2443 DFIGLSGLITPSLDEMVYVAKEMNRVGL----NIPLLIGGATTSKTHTAVKISPRYPHPV 2610
D IGLSGLITPSL+EM +VA EM R IPLLIGGAT S+ HTAVKI+P+Y PV
Sbjct: 477 DIIGLSGLITPSLEEMQHVAAEMQRDDYFRVKKIPLLIGGATCSRVHTAVKIAPKYEGPV 536
Query: 2611 VHCLDASKSVVVCSSLSDMSVRDAFLQDLNEDYEDVRQEHYASLKDRRFTDLNKTREKKF 2790
V+ DAS+SV VCS L ++++L DY+ VR +H A+ K L R K
Sbjct: 537 VYVPDASRSVGVCSELLSDERAAKYIEELKVDYDKVRLQH-ANKKATPMVSLAAARANKT 595
Query: 2791 KIDWDKFTAVKPSFVGRREYQNFDLNELIPYIDWKPFFDVWQLRGKYPNRSYPKIFDDAD 2970
IDW + +P FVGRR ++N+DL EL IDW PFF W L G ++P+I D
Sbjct: 596 PIDWRGYAPPQPKFVGRRVFRNYDLAELAQQIDWGPFFQTWDLAG-----AFPQILRDEV 650
Query: 2971 VGAEAKKVFDDAQTWLKKLIDEKILVANAVVSFLPAAS-EGDDMHVYDPETGNK-LDTFY 3144
VGAEA++V D + L++LI+ + L A+ V+ PA + DD+ +Y ET + L T++
Sbjct: 651 VGAEAQRVMSDGKRMLQRLIEGRWLQAHGVIGLYPANTVNDDDIEIYTDETRREVLMTWH 710
Query: 3145 GLRQQSGRE----HDQPHFCLSDFIKPLKNGVPDDYLGLFACTAGLGAEEYCKTLEKNHD 3312
GLR Q+ R +P+ CL+DF+ P +G+ D++GLFA TAG G ++ +HD
Sbjct: 711 GLRMQTERPVVDGVKRPNRCLADFVAPKSSGLA-DHVGLFAVTAGHGVDKKEAAFLADHD 769
Query: 3313 DYASIMVKALADRLAEAYAEYLHKEVRTTLWGYSTNEDLTESDLLSIKYQGIRPACGYPS 3492
DY++IM+KALADRLAEA+AE +H+ VRT WGY+ +E L+ L++ +Y+GIRPA GYP+
Sbjct: 770 DYSAIMLKALADRLAEAFAERMHQRVRTDFWGYAADEALSTEQLIAEQYRGIRPAPGYPA 829
Query: 3493 QPDHTEKRTLWKLLEAEKNGIGLTEHLAMLPAASVSGLYFANPQSEYFAVGKIDQDQVID 3672
PDHT KR +++ L+ E+ G+ LTE LAM PAASVSG Y A+P + YF VGKI +DQ+ D
Sbjct: 830 CPDHTVKRDMFRALQCEEIGMTLTESLAMTPAASVSGFYLAHPAAAYFNVGKIGEDQLRD 889
Query: 3673 YAARKNVPKEEVERWLSPIL 3732
+A R + ER L+P++
Sbjct: 890 WAGRTQQELAQAERALAPLM 909
>gi|16126376|ref|NP_420940.1| 5-methyltetrahydrofolate--homocysteine
methyltransferase [Caulobacter crescentus CB15]
gi|25400746|pir||H87513 hypothetical protein CC2137 [imported] -
Caulobacter crescentus
gi|13423628|gb|AAK24108.1| 5-methyltetrahydrofolate--homocysteine
methyltransferase [Caulobacter crescentus CB15]
Length = 899
Score = 879 bits (2272), Expect = 0.0
Identities = 482/901 (53%), Positives = 602/901 (66%), Gaps = 13/901 (1%)
Frame = +1
Query: 1078 FVNIGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSK 1257
FVNIGER NV GS +F LI NY A+ VAR QV++GAQ++DVNMD+GLLD AM
Sbjct: 9 FVNIGERTNVTGSAKFKKLIVEGNYPEALSVARQQVEAGAQVIDVNMDEGLLDSQQAMVT 68
Query: 1258 FLRLISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKR 1437
FL L+++EPD+A++PV IDSS ++VI AGL+ QGK +VNSISLKEGEEKF E+A + R
Sbjct: 69 FLNLMAAEPDIARVPVMIDSSKWEVIEAGLKCVQGKAIVNSISLKEGEEKFLEQATLCLR 128
Query: 1438 YGAAVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEH 1617
YGAAVVVMAFDE GQA K EIC R+Y L ++VGF P DIIFD NI +ATG+EEH
Sbjct: 129 YGAAVVVMAFDEVGQADTEKRKVEICTRAYNTLVDKVGFPPEDIIFDPNIFAVATGIEEH 188
Query: 1618 SNYGMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMG 1797
NY + FIEA R I++ LP A VSGGVSN+SFSFRG E +R A+HSVFL++AI AGMDMG
Sbjct: 189 DNYAVDFIEATRRIKQMLPYARVSGGVSNVSFSFRGNEPVRRAIHSVFLYHAINAGMDMG 248
Query: 1798 IVNAGALPVYEDIDKPXXXXXXXXXFN---RDP--EATEKLLVAAQEMXXXXXXXXXXXX 1962
IVNAG LPVY+DID N RDP TE+L+ A
Sbjct: 249 IVNAGDLPVYDDIDPALREAVEDVILNRPQRDPVMTNTERLVEMAPRYKGEKGQQQVANL 308
Query: 1963 EWRSLTVEERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFG 2142
EWR TV ERL ALV G+ +F+ DTEEAR RPL+VIE PLMDGM VVG+LFG
Sbjct: 309 EWRKGTVNERLTHALVHGITEFIEQDTEEAR---LAAERPLHVIEGPLMDGMNVVGDLFG 365
Query: 2143 AGKMFLPQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDV 2322
AGKMFLPQV+KSARVMK+AVA L+PFME E++ E G V++ATVKGDV
Sbjct: 366 AGKMFLPQVVKSARVMKQAVAWLMPFMEAEKEG---------QERKAAGKVLMATVKGDV 416
Query: 2323 HDIGKNIVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVA 2502
HDIGKNIV VVL CNN++VVDLGVM P + I+ A + K D IGLSGLITPSLDEMV+VA
Sbjct: 417 HDIGKNIVGVVLQCNNYEVVDLGVMVPADRILDEAKKHKVDMIGLSGLITPSLDEMVFVA 476
Query: 2503 KEMNRVGLNIPLLIGGATTSKTHTAVKISPRYPH-PVVHCLDASKSVVVCSSLSDMSVRD 2679
EM R G +IPLLIGGATTS+THTAVKI P Y P + +DAS++V V S L RD
Sbjct: 477 AEMERQGFDIPLLIGGATTSRTHTAVKIEPAYRRGPTTYVVDASRAVGVVSGLLSEGERD 536
Query: 2680 AFLQDLNEDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNF 2859
+ + +Y VR+++ + + + R++ F IDW + KP+F+G R ++
Sbjct: 537 RIIAETRAEYVKVREQYARGQTTKARASIQEARKRAFAIDWKGYAPPKPAFIGTRVFEP- 595
Query: 2860 DLNELIPYIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEK 3039
L EL+P+IDW PFF W+L G+ +P+I +D VG A ++ DA+ L K+++EK
Sbjct: 596 SLAELVPFIDWSPFFASWELIGR-----FPQILEDDVVGQAATDLYRDARAMLDKVVEEK 650
Query: 3040 ILVANAVVSFLPAASEGDDMHVYDPETG-NKLDTFYGLRQQSGREHD-----QPHFCLSD 3201
A V+ F PA ++GDD+ +Y ET + + LRQQ + D + + LSD
Sbjct: 651 WFGAKGVIGFWPAQAQGDDIVLYTDETRVAEFSRLHTLRQQMDKGADKSGEAKANVALSD 710
Query: 3202 FIKPLKNGVPDDYLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLH 3381
F+ P+ G DY+G FA TAG G +E + DDY +IM ALADRLAEA+AE+LH
Sbjct: 711 FVAPIGQGA--DYVGGFAVTAGHGEDEIVAKFKAAGDDYNAIMASALADRLAEAFAEWLH 768
Query: 3382 KEVRTTLWGYSTNEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAE-KNGIG 3558
+ R LWGY+ +ED L++ KYQGIRPA GYP+QPDHTEK TL+KLL+AE G+
Sbjct: 769 YKARVELWGYAADEDADVERLIAEKYQGIRPAPGYPAQPDHTEKGTLFKLLDAEAATGLQ 828
Query: 3559 LTEHLAMLPAASVSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGY 3738
LTE AM P A+VSGL+F++ Q+ YF VGKID DQV DYA RK E ERWLSPIL Y
Sbjct: 829 LTESYAMTPGAAVSGLFFSHRQAHYFGVGKIDADQVEDYARRKGWDMETAERWLSPILNY 888
Query: 3739 D 3741
D
Sbjct: 889 D 889
>gi|48850561|ref|ZP_00304803.1| COG1410: Methionine synthase I,
cobalamin-binding domain [Novosphingobium aromaticivorans
DSM 12444]
Length = 878
Score = 815 bits (2105), Expect = 0.0
Identities = 453/898 (50%), Positives = 585/898 (64%), Gaps = 11/898 (1%)
Frame = +1
Query: 1072 TNFVNIGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAM 1251
+ FVN+GER NV GS F LI +Y A++VAR QV++GAQ++DVNMD+GLLD AM
Sbjct: 8 SRFVNVGERTNVTGSAAFKKLILAGDYAKAVEVARQQVENGAQVIDVNMDEGLLDAVEAM 67
Query: 1252 SKFLRLISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARII 1431
+ FL+LI++EPD+A++PV IDSS ++VI AGL+ GK +VNSIS+KEGE+ F AR+
Sbjct: 68 TTFLKLIAAEPDIARVPVMIDSSKWEVIEAGLKCVSGKPIVNSISMKEGEDAFLHHARLC 127
Query: 1432 KRYGAAVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGME 1611
YGAAVVVMAFDE+GQA + K EICER+Y++LT +GF DIIFD NI +ATG+E
Sbjct: 128 MDYGAAVVVMAFDEKGQADTKERKVEICERAYKLLT-GIGFPAEDIIFDPNIFAVATGIE 186
Query: 1612 EHSNYGMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMD 1791
EH YG+ FIEA I+ P H+SGG+SN+SFSFRG E +R AMHSVFL++AI AGMD
Sbjct: 187 EHDRYGLDFIEATAEIKARCPHVHISGGLSNLSFSFRGNETVRRAMHSVFLYHAIPAGMD 246
Query: 1792 MGIVNAGALPVYEDIDKPXXXXXXXXXFNR------DPEATEKLLVAAQEMXXXXXXXXX 1953
M IVNAG L +Y+ ID NR D ATE+L+ A+
Sbjct: 247 MAIVNAGQLDIYDQIDPVLREACEDVVLNRAPAAGGDQTATERLIELAESYKGKDTVAEK 306
Query: 1954 XXXEWRSLTVEERLKFALVKGVDQFVVADTEEARQN-TAKYPRPLNVIERPLMDGMAVVG 2130
EWR V RL+ ALVKG+D VV DTEEAR A+ RP+ VIE PLM+GM VG
Sbjct: 307 AAEEWRGWDVVRRLEHALVKGIDAHVVEDTEEARAAIAARGGRPIEVIEGPLMEGMNTVG 366
Query: 2131 ELFGAGKMFLPQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATV 2310
+LFG+GKMFLPQV+KSARVMKKAVAHL+P++E E+ E+ + +G +++ATV
Sbjct: 367 DLFGSGKMFLPQVVKSARVMKKAVAHLIPYIEAEK----------EEGAKAKGRIIMATV 416
Query: 2311 KGDVHDIGKNIVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEM 2490
KGDVHDIGKNIV VVL CN ++V+DLGVM P I+ A +E D IGLSGLITPSLDEM
Sbjct: 417 KGDVHDIGKNIVGVVLQCNGYEVIDLGVMVPWATILDTAQKEGVDMIGLSGLITPSLDEM 476
Query: 2491 VYVAKEMNRVGLNIPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMS 2670
V VA+EM R G++IPLLIGGATTSK HTA++I P Y PVVH LDAS++V V S L +
Sbjct: 477 VTVAEEMQRAGMSIPLLIGGATTSKVHTALRIDPAYDGPVVHVLDASRAVGVASQLLSDT 536
Query: 2671 VRDAFLQDLNEDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREY 2850
F++ DY+ VR A + L R F D+ + A P GR +
Sbjct: 537 QAQGFIKATAADYQHVRDAR-AGKGASKLLSLEDARLNAFSPDFSE-KAPPPEQPGRHVF 594
Query: 2851 QNFDLNELIPYIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLI 3030
+++DL +L+ DW PFF W+L G ++P I DD VG A+ ++ DA+ L ++I
Sbjct: 595 EDWDLTDLVECFDWTPFFRSWELAG-----TWPAILDDEIVGESARNLYADARAMLDRII 649
Query: 3031 DEKILVANAVVSFLPAASEGDD--MHVYDPETGNKLDTFYGLRQQSGREHDQPHFCLSDF 3204
EK L A V F P A GDD +H D ET +L LRQQ + + +FCL+DF
Sbjct: 650 SEKWLTAKGVAQFWPCARHGDDVILHPNDDETSVRLPF---LRQQFIKSRGRANFCLADF 706
Query: 3205 IKPLKNGVPDDYLGLFACTAGL-GAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLH 3381
I P D++G FA G+ G +E+ + ++DDY+ I++KALADR AEA+AE LH
Sbjct: 707 IDP-----AGDWIGGFA--VGIHGIDEHLARFKADNDDYSDILLKALADRFAEAFAERLH 759
Query: 3382 KEVRTTLWGYSTNEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKN-GIG 3558
+ VRTTLW Y+ E LT L+ +Y+GIRPA GYP+ PDHT K L+ LL+A GI
Sbjct: 760 QYVRTTLWAYAPGEQLTNEALIREQYRGIRPAPGYPACPDHTLKPILFDLLDATNTAGIT 819
Query: 3559 LTEHLAMLPAASVSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPIL 3732
LTE AMLP ++VSG YFA+P+S+YF V I +DQ+ DYAAR+ +ERWL P L
Sbjct: 820 LTESQAMLPTSAVSGFYFAHPESQYFGVATIGRDQLEDYAARRGWDVSAMERWLRPNL 877
>gi|30022333|ref|NP_833964.1| 5-methyltetrahydrofolate--homocysteine
methyltransferase [Bacillus cereus ATCC 14579]
gi|29897890|gb|AAP11165.1| 5-methyltetrahydrofolate--homocysteine
methyltransferase [Bacillus cereus ATCC 14579]
Length = 1133
Score = 710 bits (1832), Expect = 0.0
Identities = 447/1212 (36%), Positives = 661/1212 (53%), Gaps = 7/1212 (0%)
Frame = +1
Query: 28 LAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRPDIIYKI 207
+ E K I+I+DGAMGTMIQ+E + EDF GE +G N+ L TRPD+I KI
Sbjct: 5 IEEKLKNSILILDGAMGTMIQQEDLTAEDFGGE-------EYEGCNEYLVETRPDVILKI 57
Query: 208 HKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAATGRRRY 387
HK Y+EAGAD +ETNTF T I +DY HL E+N ++AL+A++A + +G+ Y
Sbjct: 58 HKAYIEAGADIIETNTFGATNIVLSDYDLSHLDEELNEEAALLAKQAVKE----SGKEVY 113
Query: 388 VCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVETVFDSAN 567
V GA+GPT + +S++ V TF+EL++AY QAR L++G VDV+LVET D N
Sbjct: 114 VAGAMGPTTKAISVTGGV--------TFEELIEAYTRQARGLLKGAVDVVLVETSQDMRN 165
Query: 568 AKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKPMAVGLNC 747
KAA I+ FE E +P+ +SGTI M G TL+GQT EAF +S + KP++VGLNC
Sbjct: 166 VKAAYIGIQAAFE-ELKKTVPIMISGTIEPM-GTTLAGQTIEAFYLSVEHMKPLSVGLNC 223
Query: 748 ALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFARDGLVNII 927
A G + MR + ++S S+ +I CYPNAGLP+ G Y E+P +A+ ++ FA +G VNII
Sbjct: 224 ATGPEFMRDHIRSLSDLSECYISCYPNAGLPDEDGHYHESPSSLAEKVKRFAEEGWVNII 283
Query: 928 GGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVNIGERCNV 1107
GGCCGTTP+HI AM A+ + PR + G +SGLE + +GER NV
Sbjct: 284 GGCCGTTPEHIKAMKSALASLRPRDHHEREGHG---ISGLEALQYDESMRPLFVGERTNV 340
Query: 1108 AGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLRLISSEPD 1287
GSR+F L+ ++ A +VAR QV A I+D+ M D D M FL ++
Sbjct: 341 IGSRKFKRLVAEGKFEEAAEVARAQVKKNAHIIDICMADPDRDEIEDMENFLAEVTK--- 397
Query: 1288 VAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGAAVVVMAF 1467
V K+P+ IDS+D +V+ L QGK V+NSI+L++GEE+FK+ ++++YGAA+VV
Sbjct: 398 VLKVPIMIDSTDENVMERALTYIQGKAVINSINLEDGEERFKKVTPLLQKYGAAIVVGTI 457
Query: 1468 DEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNYGMYFIEA 1647
DE G A + K EI +RSY +LT++ G P+DIIFDA + + TG EE+ IE
Sbjct: 458 DEDGMAVSAERKIEIAKRSYELLTKKYGIRPSDIIFDALVFPVGTGDEEYIGSAAATIEG 517
Query: 1648 ARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVNAGALPVY 1827
R+I+E LP GVSNISF A RE ++SVFL++A KAG+D IVN L Y
Sbjct: 518 IRLIKEALPECLTILGVSNISFGL--PPAGREVLNSVFLYHATKAGLDYAIVNTEKLERY 575
Query: 1828 EDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEMXXXXXXXXXXXXEWRSLTVEERLKFAL 2007
I + F E T++ L E +LT++ERL +
Sbjct: 576 ASIPEEEKRLADALLF----ETTKETLEEFTNFYRVAKKKDVVVQE--TLTLDERLANYI 629
Query: 2008 VKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFLPQVIKSARV 2187
V+G Q + D A + K PL++I PLM GM VG LF ++ + +V++SA
Sbjct: 630 VEGTKQGLHEDLSLALEEGRK---PLDIINGPLMTGMDEVGRLFNNNELIVAEVLQSAES 686
Query: 2188 MKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKNIVSVVLGCN 2367
MK AV++L P ME +S +G V++ATVKGDVHDIGKN+V ++L N
Sbjct: 687 MKAAVSYLEPHME-------------SSDSAKKGKVLLATVKGDVHDIGKNLVEIILANN 733
Query: 2368 NFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRVGLNIPLLIG 2547
+++++LG+ + I++ E+K D IGLSGL+ S +MV A+++ +++P+++G
Sbjct: 734 GYEIINLGINVRSDRIVQEVQEKKPDIIGLSGLLVKSAQQMVTTAEDLKAANIDVPIVVG 793
Query: 2548 GATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLNEDYEDVRQE 2727
GA ++ T +ISP Y V + DA + + + L R+ QD
Sbjct: 794 GAALTRKFTDNRISPSYKGLVCYASDAMTGLDIINKLQKEEEREKMKQD----------- 842
Query: 2728 HYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIPYIDWKPFFD 2907
K R + K EKK +I K + + L + +P + PF +
Sbjct: 843 -----KKERHLHIVKKEEKKVEIPAVIEPLPKSEVMVPDSTKRIVLRD-VPALHLAPFLN 896
Query: 2908 VWQLRGKY--PNRSYPKIFDDADVGAE-----AKKVFDDAQTWLKKLIDEKILVANAVVS 3066
L G + + K+ + D A ++ + Q+WLK AV
Sbjct: 897 RQMLLGHHLGLKGNVKKLLKEGDKRAHELNDLIDELLQEGQSWLK---------PKAVYQ 947
Query: 3067 FLPAASEGDDMHVYDPETGNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDDYLG 3246
F PA S+G ++ +YDPE ++ R R+ P+ L D+++P+ G DY+
Sbjct: 948 FFPAQSDGQNIVIYDPEDHTRVIE----RFTFPRQGKAPYRTLGDYLRPI--GDEMDYVA 1001
Query: 3247 LFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYSTNED 3426
+ T G G + + L+ D S +++LA LAE AE H +R WG + +
Sbjct: 1002 FLSVTVGEGVRDIAEELKAKGDYLRSHAIQSLALELAEGLAEKTHMLIRDR-WGIPDSPE 1060
Query: 3427 LTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKNGIGLTEHLAMLPAASVSGL 3606
LT + KY+GIR + GYP+ P+ ++ L++L+ E+ GI LTE M P ASV+ +
Sbjct: 1061 LTMEERFRTKYRGIRVSFGYPACPELADQEKLFRLIHPEEIGISLTEGFMMEPEASVTAM 1120
Query: 3607 YFANPQSEYFAV 3642
F++P++ YF+V
Sbjct: 1121 VFSHPEARYFSV 1132
>gi|42783378|ref|NP_980625.1| 5-methyltetrahydrofolate--homocysteine
methyltransferase [Bacillus cereus ATCC 10987]
gi|42739306|gb|AAS43233.1| 5-methyltetrahydrofolate--homocysteine
methyltransferase [Bacillus cereus ATCC 10987]
Length = 1132
Score = 702 bits (1811), Expect = 0.0
Identities = 446/1212 (36%), Positives = 652/1212 (52%), Gaps = 7/1212 (0%)
Frame = +1
Query: 28 LAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRPDIIYKI 207
+ E + I+I+DGAMGTMIQ+E + EDF GE +G N+ L TRPD+I KI
Sbjct: 4 IEEKLQNNILILDGAMGTMIQQEDLTAEDFGGE-------EYEGCNEYLVETRPDVILKI 56
Query: 208 HKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAATGRRRY 387
HK Y+EAGAD +ETNTF T I +DY HL E+N ++A +A++A ++ +G+ Y
Sbjct: 57 HKAYIEAGADIIETNTFGATNIVLSDYELSHLDEELNEKAARLAKQAVEE----SGKEVY 112
Query: 388 VCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVETVFDSAN 567
V GA+GPT + +S++ V TF+EL++AY QAR L++G VDVLLVET D N
Sbjct: 113 VAGAMGPTTKAISVTGGV--------TFEELIEAYTRQARGLLKGEVDVLLVETSQDMRN 164
Query: 568 AKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKPMAVGLNC 747
KAA I+ F DE +P+ +SGTI M G TL+GQT EAF +S + KP++VGLNC
Sbjct: 165 VKAAYIGIQAAF-DELNTIVPIMISGTIEPM-GTTLAGQTIEAFYLSVEHMKPLSVGLNC 222
Query: 748 ALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFARDGLVNII 927
A G + MR + ++S S+ +I CYPNAGLP+ G Y E+P +A+ ++ FA +G VNII
Sbjct: 223 ATGPEFMRDHIRSLSDLSECYISCYPNAGLPDEDGHYHESPSSLAEKVKRFAEEGWVNII 282
Query: 928 GGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVNIGERCNV 1107
GGCCGTTP+HI AM A+ + PR Q AG +SGLE + +GER NV
Sbjct: 283 GGCCGTTPEHIKAMKSALTSLKPR--EQQERAGHG-VSGLEALQYDDSMRPLFVGERTNV 339
Query: 1108 AGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLRLISSEPD 1287
GSR+F L+ ++ A ++AR QV A I+D+ M D D M FL ++
Sbjct: 340 IGSRKFKRLVAEGKFEEAAEIARAQVKKNAHIIDICMADPDRDEIEDMENFLAEVTK--- 396
Query: 1288 VAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGAAVVVMAF 1467
V K+P+ IDS+D V+ L QGK V+NSI+L++GEE+FK+ ++++YGAA+VV
Sbjct: 397 VLKVPIMIDSTDEHVMERALTYIQGKAVINSINLEDGEERFKKVTPLLRKYGAAIVVGTI 456
Query: 1468 DEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNYGMYFIEA 1647
DE G A + K EI +RSY +LT + G P+DIIFDA + + TG EE+ IE
Sbjct: 457 DEDGMAVSAERKLEIAKRSYELLTTKYGIRPSDIIFDALVFPVGTGDEEYIGSAAATIEG 516
Query: 1648 ARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVNAGALPVY 1827
R+I+E LP GVSNISF A RE ++SVFL++A KAG+D IVN L Y
Sbjct: 517 IRLIKEALPECLTILGVSNISFGL--PPAGREVLNSVFLYHATKAGLDYAIVNTEKLERY 574
Query: 1828 EDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEMXXXXXXXXXXXXEWRSLTVEERLKFAL 2007
I F E EK +LT++ERL +
Sbjct: 575 ASIPDEEKRLADALLFETTQETLEKF------TNFYRVAKKKDVVVQETLTLDERLANYI 628
Query: 2008 VKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFLPQVIKSARV 2187
V+G Q + D A K PL++I PLM GM VG LF ++ + +V++SA
Sbjct: 629 VEGTKQGLHEDLSLALTEGRK---PLDIINGPLMTGMDEVGRLFNNNELIVAEVLQSAES 685
Query: 2188 MKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKNIVSVVLGCN 2367
MK AV++L P ME +S +G V++ATVKGDVHDIGKN+V ++L N
Sbjct: 686 MKAAVSYLEPHME-------------SSDSAKKGKVLLATVKGDVHDIGKNLVEIILANN 732
Query: 2368 NFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRVGLNIPLLIG 2547
+++++LG+ + I++ E+K D IGLSGL+ S +MV A+++ ++IP+++G
Sbjct: 733 GYEIINLGINVRSDRIVQEVQEKKPDIIGLSGLLVKSAQQMVTTAEDLKAADIDIPIVVG 792
Query: 2548 GATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLNEDYEDVRQE 2727
GA ++ T +ISP Y V + DA + + + L R+ QD
Sbjct: 793 GAALTRKFTDNRISPSYKGLVCYASDAMTGLDIINKLQKEEEREKMKQD----------- 841
Query: 2728 HYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIPYIDWKPFFD 2907
K R + EKK +I K + + L + +P PF +
Sbjct: 842 -----KKERHLHIVTKEEKKVEIPAVIEPLPKAEVIVPDSTKRIVLRD-VPVSHLAPFLN 895
Query: 2908 VWQLRGKY--PNRSYPKIFDDADVGAE-----AKKVFDDAQTWLKKLIDEKILVANAVVS 3066
L G + S K+ + D A ++ + Q+WLK AV
Sbjct: 896 RQMLLGHHLGLKGSVKKLLREGDKRAHELNDLIDELLQEGQSWLK---------PKAVYQ 946
Query: 3067 FLPAASEGDDMHVYDPETGNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDDYLG 3246
F PA S+G ++ +YDPE ++ R R+ P+ L D+++P+ G DY+
Sbjct: 947 FFPAQSDGQNIVIYDPEDHTRVIE----RFTFPRQGKAPYRTLGDYLRPV--GDEMDYVA 1000
Query: 3247 LFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYSTNED 3426
+ T G G + + + D S +++LA LAE AE H +R WG + +
Sbjct: 1001 FLSVTVGEGVRDIAEEWKAKGDYLRSHAIQSLALELAEGLAEKTHMLIRDR-WGIPDSPE 1059
Query: 3427 LTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKNGIGLTEHLAMLPAASVSGL 3606
LT + KY+GIR + GYP+ P+ ++ L++L+ E+ GI LTE M P ASV+ +
Sbjct: 1060 LTMEERFRTKYRGIRVSFGYPACPELADQEKLFRLIHPEEIGISLTEGFMMEPEASVTAM 1119
Query: 3607 YFANPQSEYFAV 3642
F++P++ YF+V
Sbjct: 1120 VFSHPEARYFSV 1131
>gi|47567815|ref|ZP_00238523.1| 5-methyltetrahydrofolate--homocysteine
methyltransferase [Bacillus cereus G9241]
gi|47555492|gb|EAL13835.1| 5-methyltetrahydrofolate--homocysteine
methyltransferase [Bacillus cereus G9241]
Length = 1132
Score = 698 bits (1802), Expect = 0.0
Identities = 445/1212 (36%), Positives = 657/1212 (53%), Gaps = 7/1212 (0%)
Frame = +1
Query: 28 LAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRPDIIYKI 207
+ E + I+++DGAMGTMIQ+E + EDF GE +G N+ L TRPD+I KI
Sbjct: 4 IEEKLRNNILLLDGAMGTMIQQEDLTAEDFGGE-------EYEGCNEYLVETRPDVILKI 56
Query: 208 HKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAATGRRRY 387
HK Y+EAGAD +ETNTF T I +DY +L E+N ++A +A++A ++ +G+ Y
Sbjct: 57 HKAYIEAGADIIETNTFGATNIVLSDYELSYLDEELNEKAARLAKQAVEE----SGKEVY 112
Query: 388 VCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVETVFDSAN 567
V GA+GPT + +S++ V TF+EL++AY QAR L++G VDVLLVET D N
Sbjct: 113 VAGAMGPTTKAISVTGGV--------TFEELIEAYTRQARGLLKGEVDVLLVETSQDMRN 164
Query: 568 AKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKPMAVGLNC 747
KAA I+ F DE +P+ +SGTI M G TL+GQT EAF +S + KP++VGLNC
Sbjct: 165 VKAAYIGIQAAF-DELNKIVPIMISGTIEPM-GTTLAGQTIEAFYLSVEHMKPLSVGLNC 222
Query: 748 ALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFARDGLVNII 927
A G + MR + ++S S+ +I CYPNAGLP+ G Y E+P +A+ ++ FA +G VNII
Sbjct: 223 ATGPEFMRDHIRSLSDLSECYISCYPNAGLPDEDGHYHESPSSLAEKVKRFAEEGWVNII 282
Query: 928 GGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVNIGERCNV 1107
GGCCGTTP+HI AM A+ + PR Q AG +SGLE + +GER NV
Sbjct: 283 GGCCGTTPEHIKAMKSALASLKPR--EQQERAGHG-VSGLEALQYDDSMRPLFVGERTNV 339
Query: 1108 AGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLRLISSEPD 1287
GSR+F L+ ++ A +VAR QV A I+D+ M D D M FL ++
Sbjct: 340 IGSRKFKRLVAEGKFEEAAEVARAQVKKNAHIIDICMADPDRDEIEDMENFLAEVTK--- 396
Query: 1288 VAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGAAVVVMAF 1467
V K+P+ IDS+D +V+ L QGK V+NSI+L++GEE+F + ++++YGAA+VV
Sbjct: 397 VLKVPIMIDSTDENVMERALTYIQGKAVINSINLEDGEERFIKVTPLLQKYGAAIVVGTI 456
Query: 1468 DEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNYGMYFIEA 1647
DE G A + K EI +RSY +LT + G P+DIIFDA + + TG EE+ IE
Sbjct: 457 DEDGMAVSAERKLEIAKRSYELLTTKYGIRPSDIIFDALVFPVGTGDEEYIGSAAATIEG 516
Query: 1648 ARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVNAGALPVY 1827
R+I+E LP GVSNISF A RE ++SVFL++A KAG+D IVN L Y
Sbjct: 517 IRLIKETLPECLTILGVSNISFGL--PPAGREVLNSVFLYHATKAGLDYAIVNTEKLERY 574
Query: 1828 EDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEMXXXXXXXXXXXXEWRSLTVEERLKFAL 2007
I + F E T++ L E +LT++ERL +
Sbjct: 575 ASIPEEEKRLADALLF----ETTQETLEEFTNFYRAAKKKDVVIQE--TLTLDERLANYI 628
Query: 2008 VKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFLPQVIKSARV 2187
V+G Q + D A K PL++I PLM GM VG LF ++ + +V++SA
Sbjct: 629 VEGTKQGLQEDLSIALTEGRK---PLDIINGPLMTGMDEVGRLFNNNELIVAEVLQSAES 685
Query: 2188 MKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKNIVSVVLGCN 2367
MK AV++L P ME +S +G V++ATVKGDVHDIGKN+V ++L N
Sbjct: 686 MKAAVSYLEPHME-------------SSDSAKKGKVLLATVKGDVHDIGKNLVEIILANN 732
Query: 2368 NFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRVGLNIPLLIG 2547
+++++LG+ + I++ E+K D IGLSGL+ S +MV A+++ ++IP+++G
Sbjct: 733 GYEIINLGINVRSDRIVQEVQEKKPDIIGLSGLLVKSAQQMVTTAEDLKAADIDIPIVVG 792
Query: 2548 GATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLNEDYEDVRQE 2727
GA ++ T +ISP Y V + DA + + + L R+ QD
Sbjct: 793 GAALTRKFTDNRISPSYKGLVCYASDAMTGLDIINKLQKEEEREKMKQD----------- 841
Query: 2728 HYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIPYIDWKPFFD 2907
K R + EKK +I K + + L + IP + PF +
Sbjct: 842 -----KKERHLHIVTKEEKKVEIPAVIEPLPKSEVMVPDSTKRIVLRD-IPALHLAPFLN 895
Query: 2908 VWQLRGKY--PNRSYPKIFDDADVGAE-----AKKVFDDAQTWLKKLIDEKILVANAVVS 3066
L G + S K+ + D A ++ + Q+WLK AV
Sbjct: 896 RQMLLGHHLGLKGSVKKLLREGDKRAHELNDLIDELLQEGQSWLK---------PKAVYQ 946
Query: 3067 FLPAASEGDDMHVYDPETGNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDDYLG 3246
F PA S+G ++ +YDP+ ++ R R+ P+ L D+++P+ G DY+
Sbjct: 947 FFPAQSDGQNIVIYDPQDHTRVIE----RFTFPRQGKAPYRTLGDYLRPI--GDEMDYVA 1000
Query: 3247 LFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYSTNED 3426
+ T G G + + + D S +++LA LAE AE H +R WG + +
Sbjct: 1001 FLSVTVGEGVRDIAEEWKAKGDYLRSHAIQSLALELAEGLAEKTHMLIRDR-WGIPDSPE 1059
Query: 3427 LTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKNGIGLTEHLAMLPAASVSGL 3606
LT + KY+GIR + GYP+ P+ ++ L++L+ E+ GI LTE M P ASV+ +
Sbjct: 1060 LTMEERFRTKYRGIRVSFGYPACPELADQEKLFRLIHPEEIGISLTEGFMMEPEASVTAM 1119
Query: 3607 YFANPQSEYFAV 3642
F++P++ YF+V
Sbjct: 1120 VFSHPEARYFSV 1131
>gi|49478593|ref|YP_038314.1| 5-methyltetrahydrofolate--homocysteine
methyltransferase [Bacillus thuringiensis serovar
konkukian str. 97-27]
gi|49330149|gb|AAT60795.1| 5-methyltetrahydrofolate--homocysteine
methyltransferase [Bacillus thuringiensis serovar
konkukian str. 97-27]
Length = 1133
Score = 698 bits (1802), Expect = 0.0
Identities = 446/1212 (36%), Positives = 655/1212 (53%), Gaps = 7/1212 (0%)
Frame = +1
Query: 28 LAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRPDIIYKI 207
+ E K I+++DGAMGTMIQ+E + EDF GE +G N+ L TRPD+I KI
Sbjct: 5 IEEKLKNNILLLDGAMGTMIQQEDLTAEDFGGE-------EYEGCNEYLVETRPDVILKI 57
Query: 208 HKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAATGRRRY 387
HK Y+EAGAD +ETNTF T I +DY HL E+N ++A +A++A + +G+ Y
Sbjct: 58 HKAYIEAGADIIETNTFGATNIVLSDYELSHLDEELNEKAARLAKQAVKE----SGKEVY 113
Query: 388 VCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVETVFDSAN 567
V GA+GPT + +S++ V TF+EL++AY QAR L++G VDVLLVET D N
Sbjct: 114 VAGAMGPTTKAISVTGGV--------TFEELIEAYTRQARGLLKGEVDVLLVETSQDMRN 165
Query: 568 AKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKPMAVGLNC 747
KAA I+ F DE +P+ +SGTI M G TL+GQT EAF +S + KP++VGLNC
Sbjct: 166 VKAAYIGIQAAF-DELKKIVPIMISGTIEPM-GTTLAGQTIEAFYLSVEHMKPLSVGLNC 223
Query: 748 ALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFARDGLVNII 927
A G + MR + ++S S +I CYPNAGLP+ G Y E+P +A+ ++ FA +G VNII
Sbjct: 224 ATGPEFMRDHIRSLSDLSGGYISCYPNAGLPDEDGHYHESPSSLAEKVKRFAEEGWVNII 283
Query: 928 GGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVNIGERCNV 1107
GGCCGTTP+HI AM +A+ + PR + G +SGLE + +GER NV
Sbjct: 284 GGCCGTTPEHIKAMKEALASLKPREHHEREGHG---VSGLEALQYDDSMRPLFVGERTNV 340
Query: 1108 AGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLRLISSEPD 1287
GSR+F L+ ++ A +VAR QV A I+D+ M D D M FL ++
Sbjct: 341 IGSRKFKRLVAEGKFEEAAEVARAQVKKNAHIIDICMADPDRDEIEDMENFLAEVTK--- 397
Query: 1288 VAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGAAVVVMAF 1467
V K+P+ IDS+D V+ L QGK V+NSI+L++GEE+F + ++++YGAA+VV
Sbjct: 398 VLKVPIMIDSTDEHVMERALTYIQGKAVINSINLEDGEERFIKVTPLLQKYGAAIVVGTI 457
Query: 1468 DEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNYGMYFIEA 1647
DE G A + K EI +RSY +LT + G P+DIIFDA + + TG EE+ IE
Sbjct: 458 DEDGMAVSAERKLEIAKRSYELLTTKYGIRPSDIIFDALVFPVGTGDEEYIGSAAATIEG 517
Query: 1648 ARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVNAGALPVY 1827
R+I+E LP GVSNISF A RE ++SVFL++A KAG+D IVN L Y
Sbjct: 518 IRLIKEALPECLTILGVSNISFGL--PPAGREVLNSVFLYHATKAGLDYAIVNTEKLERY 575
Query: 1828 EDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEMXXXXXXXXXXXXEWRSLTVEERLKFAL 2007
I F E T++ L E +LT++ERL +
Sbjct: 576 ASIPDEEKRLADALLF----ETTQETLEEFTNFYRVAKKKDVVVQE--TLTLDERLANYI 629
Query: 2008 VKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFLPQVIKSARV 2187
V+G Q + D A K PL++I PLM GM VG LF ++ + +V++SA
Sbjct: 630 VEGTKQGLHEDLSLALTEGRK---PLDIINGPLMTGMDEVGRLFNNNELIVAEVLQSAES 686
Query: 2188 MKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKNIVSVVLGCN 2367
MK AV++L P ME +S +G V++ATVKGDVHDIGKN+V ++L N
Sbjct: 687 MKAAVSYLEPHME-------------SSDSAKKGKVLLATVKGDVHDIGKNLVEIILANN 733
Query: 2368 NFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRVGLNIPLLIG 2547
+++++LG+ + I++ E+K D IGLSGL+ S +MV A+++ ++IP+++G
Sbjct: 734 GYEIINLGINVRSDRIVQEVQEKKPDIIGLSGLLVKSAQQMVTTAEDLKAADIDIPIVVG 793
Query: 2548 GATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLNEDYEDVRQE 2727
GA ++ T +ISP Y V + DA + + + L R+ QD
Sbjct: 794 GAALTRKFTDNRISPSYKGLVCYASDAMTGLDIINKLQKEEEREKMKQD----------- 842
Query: 2728 HYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIPYIDWKPFFD 2907
K R + EKK +I K + + L + +P + PF +
Sbjct: 843 -----KKERHLHIVTKEEKKIEIPAVIEPLPKSEVMVPDSTKRIVLRD-VPALHLAPFLN 896
Query: 2908 VWQLRGKY--PNRSYPKIFDDADVGAE-----AKKVFDDAQTWLKKLIDEKILVANAVVS 3066
L G + S K+ + D A ++ + Q+WLK AV
Sbjct: 897 RQMLLGHHLGLKGSVKKLLKEGDKRAHELNDLIDELLQEGQSWLK---------PKAVYQ 947
Query: 3067 FLPAASEGDDMHVYDPETGNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDDYLG 3246
F PA S+G ++ +YDPE ++ + +Q GR P+ L D+++P+ G DY+
Sbjct: 948 FFPAQSDGQNIVIYDPEDHTRVIERFTFPRQ-GR---APYRTLGDYLRPI--GDEMDYVA 1001
Query: 3247 LFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYSTNED 3426
+ T G G + + + D S +++LA LAE AE H +R WG + +
Sbjct: 1002 FLSVTVGEGVRDIAEEWKAKGDYLRSHAIQSLALELAEGLAEKTHMLIRDR-WGIPDSPE 1060
Query: 3427 LTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKNGIGLTEHLAMLPAASVSGL 3606
LT + KY+GIR + GYP+ P+ ++ L++L+ E+ GI LTE M P ASV+ +
Sbjct: 1061 LTMEERFRTKYRGIRVSFGYPACPELADQEKLFRLIHPEEIGISLTEGFMMEPEASVTAM 1120
Query: 3607 YFANPQSEYFAV 3642
F++P++ YF+V
Sbjct: 1121 VFSHPEARYFSV 1132
>gi|21402300|ref|NP_658285.1| S-methyl_trans, Homocysteine
S-methyltransferase [Bacillus anthracis A2012]
gi|30264326|ref|NP_846703.1| 5-methyltetrahydrofolate--homocysteine
methyltransferase [Bacillus anthracis str. Ames]
gi|47778299|ref|YP_021121.2| 5-methyltetrahydrofolate--homocysteine
methyltransferase [Bacillus anthracis str. 'Ames
Ancestor']
gi|49187153|ref|YP_030405.1| 5-methyltetrahydrofolate--homocysteine
methyltransferase [Bacillus anthracis str. Sterne]
gi|30258971|gb|AAP28189.1| 5-methyltetrahydrofolate--homocysteine
methyltransferase [Bacillus anthracis str. Ames]
gi|47552004|gb|AAT33596.2| 5-methyltetrahydrofolate--homocysteine
methyltransferase [Bacillus anthracis str. 'Ames
Ancestor']
gi|49181080|gb|AAT56456.1| 5-methyltetrahydrofolate--homocysteine
methyltransferase [Bacillus anthracis str. Sterne]
Length = 1132
Score = 696 bits (1795), Expect = 0.0
Identities = 445/1212 (36%), Positives = 655/1212 (53%), Gaps = 7/1212 (0%)
Frame = +1
Query: 28 LAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRPDIIYKI 207
+ E + I+++DGAMGTMIQ+E + EDF GE +G N+ L TRPD+I KI
Sbjct: 4 IEEKLQNNILLLDGAMGTMIQQEDLTAEDFGGE-------EYEGCNEYLVETRPDVILKI 56
Query: 208 HKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAATGRRRY 387
HK Y+EAGAD +ETNTF T I +DY HL E+N ++A +A++A + +G+ Y
Sbjct: 57 HKAYIEAGADIIETNTFGATNIVLSDYELSHLDEELNEKAARLAKQAVKE----SGKEVY 112
Query: 388 VCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVETVFDSAN 567
V GA+GPT + +S++ V TF+EL++AY QAR L++G VDVLLVET D N
Sbjct: 113 VAGAMGPTTKAISVTGGV--------TFEELIEAYTRQARGLLKGEVDVLLVETSQDMRN 164
Query: 568 AKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKPMAVGLNC 747
KAA I+ F DE +P+ +SGTI M G TL+GQT EAF +S + KP++VGLNC
Sbjct: 165 MKAAYIGIQAAF-DELKKIVPIMISGTIEPM-GTTLAGQTIEAFYLSVEHMKPLSVGLNC 222
Query: 748 ALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFARDGLVNII 927
A G + MR + ++S S+ +I CYPNAGLP+ G Y E+P +A+ ++ FA +G VNII
Sbjct: 223 ATGPEFMRDHIRSLSDLSECYISCYPNAGLPDEDGHYHESPSSLAEKVKRFAEEGWVNII 282
Query: 928 GGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFVNIGERCNV 1107
GGCCGTTP+HI AM +A+ + PR + G +SGLE + +GER NV
Sbjct: 283 GGCCGTTPEHIKAMKEALASLKPREHHEREGHG---VSGLEALQYDDSMRPLFVGERTNV 339
Query: 1108 AGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLRLISSEPD 1287
GSR+F L+ ++ A +VAR QV A I+D+ M D D M FL ++
Sbjct: 340 IGSRKFKRLVAEGKFEEAAEVARAQVKKNAHIIDICMADPDRDEIEDMENFLAEVTK--- 396
Query: 1288 VAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGAAVVVMAF 1467
V K+P+ IDS+D V+ L QGK V+NSI+L++GEE+F + ++++YGAA+VV
Sbjct: 397 VLKVPIMIDSTDEHVMERALTYIQGKAVINSINLEDGEERFIKVTPLLQKYGAAIVVGTI 456
Query: 1468 DEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNYGMYFIEA 1647
DE G A + K EI +RSY +LT + G P+DIIFDA + + TG EE+ IE
Sbjct: 457 DEDGMAVSAERKLEIAKRSYELLTTKYGIRPSDIIFDALVFPVGTGDEEYIGSAAATIEG 516
Query: 1648 ARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVNAGALPVY 1827
R+I+E LP GVSNISF A RE ++SVFL++A KAG+D IVN L Y
Sbjct: 517 IRLIKEALPECLTILGVSNISFGL--PPAGREVLNSVFLYHATKAGLDYAIVNTEKLERY 574
Query: 1828 EDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEMXXXXXXXXXXXXEWRSLTVEERLKFAL 2007
I F E T++ L E +LT++ERL +
Sbjct: 575 ASIPDEEKRLADALLF----ETTQETLEEFTNFYRVAKKKDVVVQE--TLTLDERLANYI 628
Query: 2008 VKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFLPQVIKSARV 2187
V+G Q + D A K PL++I PLM GM VG LF ++ + +V++SA
Sbjct: 629 VEGTKQGLHEDLSLALTEGRK---PLDIINGPLMTGMDEVGRLFNNNELIVAEVLQSAES 685
Query: 2188 MKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKNIVSVVLGCN 2367
MK AV++L P ME +S +G V++ATVKGDVHDIGKN+V ++L N
Sbjct: 686 MKAAVSYLEPHME-------------SSDSAKKGKVLLATVKGDVHDIGKNLVEIILANN 732
Query: 2368 NFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRVGLNIPLLIG 2547
+++++LG+ + I++ E+K D IGLSGL+ S +MV A+++ ++IP+++G
Sbjct: 733 GYEIINLGINVRSDRIVQEVQEKKPDIIGLSGLLVKSAQQMVTTAEDLKAADIDIPIVVG 792
Query: 2548 GATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLNEDYEDVRQE 2727
GA ++ T +ISP Y V + DA + + + L R+ QD
Sbjct: 793 GAALTRKFTDNRISPSYKGLVCYASDAMTGLDIINKLQKEEEREKMKQD----------- 841
Query: 2728 HYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIPYIDWKPFFD 2907
K R + EKK +I K + + L + +P + PF +
Sbjct: 842 -----KKERHLHIVTKEEKKIEIPAVIEPLPKSEVMVPDSTKRIVLRD-VPALHLAPFLN 895
Query: 2908 VWQLRGKY--PNRSYPKIFDDADVGAE-----AKKVFDDAQTWLKKLIDEKILVANAVVS 3066
L G + S K+ + D A ++ + Q+WLK AV
Sbjct: 896 RQMLLGHHLGLKGSVKKLLKEGDKRAHELNDLIDELLQEGQSWLK---------PKAVYQ 946
Query: 3067 FLPAASEGDDMHVYDPETGNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDDYLG 3246
F PA S+G ++ +YDPE ++ + +Q GR P+ L D+++P+ G DY+
Sbjct: 947 FFPAQSDGQNIVIYDPEDHTRVIERFTFPRQ-GR---APYRTLGDYLRPI--GDEMDYVA 1000
Query: 3247 LFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYSTNED 3426
+ T G G + + D S +++LA LAE AE H +R WG + +
Sbjct: 1001 FLSVTVGEGVRGIAEEWKAKGDYLRSHAIQSLALELAEGLAEKTHMLIRDR-WGIPDSPE 1059
Query: 3427 LTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKNGIGLTEHLAMLPAASVSGL 3606
LT + KY+GIR + GYP+ P+ ++ L++L+ E+ GI LTE M P ASV+ +
Sbjct: 1060 LTMEERFRTKYRGIRVSFGYPACPELADQEKLFRLIHPEEIGISLTEGFMMEPEASVTAM 1119
Query: 3607 YFANPQSEYFAV 3642
F++P++ YF+V
Sbjct: 1120 VFSHPEARYFSV 1131
>gi|15614193|ref|NP_242496.1| 5-methyltetrahydrofolate S-homocysteine
methyltransferase [Bacillus halodurans C-125]
gi|25285951|pir||F83853 5-methyltetrahydrofolate S-homocysteine
methyltransferase metH [imported] - Bacillus halodurans
(strain C-125)
gi|10174247|dbj|BAB05349.1| 5-methyltetrahydrofolate S-homocysteine
methyltransferase [Bacillus halodurans C-125]
Length = 1146
Score = 693 bits (1788), Expect = 0.0
Identities = 429/1212 (35%), Positives = 668/1212 (54%), Gaps = 2/1212 (0%)
Frame = +1
Query: 13 SLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRPD 192
SLFE+ E +I+I+DGAMGTM+Q + +DF GE +G N+ L+ T P
Sbjct: 4 SLFEQQLE---RKIVILDGAMGTMLQAANLTADDFGGE-------EYEGCNEYLNETAPH 53
Query: 193 IIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAAT 372
++ IH+ YLEAGAD + TNTF T I DY + E+N + +A+R ++
Sbjct: 54 VVEDIHRAYLEAGADVIATNTFGATDIVLDDYDLGYKAEELNICAVKIAKRVAEEFSTPD 113
Query: 373 GRRRYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVETV 552
R +V GA+GPT ++LS++ TF++L+++Y QA LI+GG D+LL+ET
Sbjct: 114 WPR-FVAGAMGPTTKSLSVTGGA--------TFEQLIESYRQQATGLIKGGADILLLETS 164
Query: 553 FDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKPMA 732
D N KAA + ++ V ++P+ +SGTI M G TL+GQ EAF +S + P+
Sbjct: 165 QDMRNVKAAYLGLSQAQKELEV-KLPLIISGTIEPM-GTTLAGQNIEAFYLSLEHMNPVV 222
Query: 733 VGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFARDG 912
VGLNCA G + MR + ++S + + CYPNAGLP+ G Y E+PE +A L FA G
Sbjct: 223 VGLNCATGPEFMRDHLRSLSDLATCSVSCYPNAGLPDEEGNYHESPESLAAKLAGFAEKG 282
Query: 913 LVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQD-PHAGKMLLSGLEPSIVGPETNFVNI 1089
+N++GGCCGTTPDHI A+ ++ PR P D PH+ +SG+EP + + +
Sbjct: 283 WLNMVGGCCGTTPDHIRALLDVMKQFEPRQPKGDHPHS----VSGIEPLLYDDSMRPLFV 338
Query: 1090 GERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLRL 1269
GER NV GSR+F LI+ E Y+ A ++AR QV GA ++DV + D D M +FL+
Sbjct: 339 GERTNVIGSRKFKRLIEEEKYEEASEIARSQVKKGAHVIDVCLADPDRDEMEDMEEFLKF 398
Query: 1270 ISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGAA 1449
+ ++ K+P+ IDS+D VI L +QGK ++NSI+L++GEE+F++ ++ +YGAA
Sbjct: 399 VINK---VKVPLMIDSTDEKVIEQALTYSQGKAIINSINLEDGEERFEKVVPLVHKYGAA 455
Query: 1450 VVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNYG 1629
VVV DE+G A + K + +RSY +L + P+DIIFD + + TG E++
Sbjct: 456 VVVGTIDEEGMAITAEKKLAVAKRSYDLLVNKYNIRPSDIIFDPLVFPVGTGDEQYIGSA 515
Query: 1630 MYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAI-REAMHSVFLFYAIKAGMDMGIVN 1806
+E R I+E LP GVSN+SF G+ + RE +++ +L++ +AG+D IVN
Sbjct: 516 NETVEGIRRIKEELPECLTILGVSNVSF---GLPPVGREVLNAAYLYHCTQAGLDYAIVN 572
Query: 1807 AGALPVYEDIDKPXXXXXXXXXFNRDPEATEKLLVAAQEMXXXXXXXXXXXXEWRSLTVE 1986
L Y I F E T++ L A+ E +LT+E
Sbjct: 573 TEKLERYASISDEEKELSRKLLF----ETTDETL--AEFTAFYRGKKAEKKVETSNLTLE 626
Query: 1987 ERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFLPQ 2166
ERL +V+G + D ++A AKY PL++I PLM+GM VG LF ++ + +
Sbjct: 627 ERLANYIVEGSKDGLTEDLDKA---LAKYDDPLDIINGPLMNGMDEVGRLFNNNELIVAE 683
Query: 2167 VIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKNIV 2346
V++SA VMK +VAHL P ME + A+D +G +++ATVKGDVHDIGKN+V
Sbjct: 684 VLQSAEVMKASVAHLEPHMEKK----------ADDHG--KGKIILATVKGDVHDIGKNLV 731
Query: 2347 SVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRVGL 2526
++L N F++V+LG+ +I+A E D IGLSGL+ S +MV A+++ + +
Sbjct: 732 EIILSNNGFRIVNLGIKVTSNELIEAVARENPDAIGLSGLLVKSAQQMVLTAQDLKQQQI 791
Query: 2527 NIPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLNED 2706
+IP+L+GGA ++ T KI+P Y VV+ DA + + + L R+ L+E
Sbjct: 792 SIPILVGGAALTRKFTNTKIAPEYDGLVVYAKDAMNGLELANKLMKPDEREKLAVSLHEA 851
Query: 2707 YEDVRQEHYASLKDRRFTDLNKTREKKFKIDWDKFTAVKPSFVGRREYQNFDLNELIPYI 2886
E + + + AV P V ++ + L PYI
Sbjct: 852 KEQANSRTQMGGGGTAVA----VKPTRSHVSTTVPVAVPPD-VKPHILRHHSIAHLEPYI 906
Query: 2887 DWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAVVS 3066
+ + L G++ A+ +A ++ + L ++ +E+++ A+ +
Sbjct: 907 NMQ------MLLGRHLGLQGKVSRLLAEKDEKALELKEKVDALLTRVKEEQLMEAHGMYQ 960
Query: 3067 FLPAASEGDDMHVYDPETGNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDDYLG 3246
F PA S+GDD+ +YD N+++ F+ RQ + +P+ CL+DF++P+ +G DY+G
Sbjct: 961 FFPAQSDGDDIVIYDQTGTNEIERFHFPRQ-----NKEPYLCLADFLRPVSSG-EMDYVG 1014
Query: 3247 LFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYSTNED 3426
A TAG G E + ++ D S +++A A +AE +AE +H+ +R WG+ + D
Sbjct: 1015 FLAVTAGKGIRELGEQAKEAGDYLFSHLIQATALEMAEGFAERVHQLMRDK-WGFPDSAD 1073
Query: 3427 LTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKNGIGLTEHLAMLPAASVSGL 3606
T + + KY+GIR + GYP+ PD ++ L+KLL+ K GI LTE M P ASV+ +
Sbjct: 1074 FTMEERFAAKYRGIRVSFGYPACPDLDDQAKLFKLLKPGKIGIELTEGFMMEPEASVTAM 1133
Query: 3607 YFANPQSEYFAV 3642
FA+P++ YF V
Sbjct: 1134 VFAHPEARYFNV 1145
>gi|3122391|sp|O33465|METH_PSEPU Methionine synthase
(5-methyltetrahydrofolate--homocysteine
methyltransferase) (Methionine synthase, vitamin-B12
dependent isozyme) (MS)
gi|2612820|emb|CAA04437.1| methionine synthase [Pseudomonas putida]
Length = 607
Score = 670 bits (1728), Expect = 0.0
Identities = 340/607 (56%), Positives = 442/607 (72%), Gaps = 1/607 (0%)
Frame = +1
Query: 7 RSSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITR 186
RS+ + L KERI+I+DG MGTMIQ +EE D+RG D +KGNNDLL ++R
Sbjct: 4 RSARLQALQNALKERILILDGGMGTMIQSYRLEEHDYRGTRFADWPSDVKGNNDLLLLSR 63
Query: 187 PDIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGA 366
PD+I I K YL+AGAD +ETNTF+ T I+QADY E LV+E+N + A +AR+ D
Sbjct: 64 PDVIAAIEKAYLDAGADILETNTFNATQISQADYGMESLVYELNVEGARIARQVADAKTL 123
Query: 367 AT-GRRRYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLV 543
T + R+V G +GPT+RT SISP V P +RNVTF ELV+ Y + R LI+GG D++L+
Sbjct: 124 ETPDKPRFVAGVLGPTSRTCSISPDVNDPGYRNVTFDELVENYIEATRGLIEGGADLILI 183
Query: 544 ETVFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGK 723
ET+FD+ NAKAA+FA++ +FE++ V E+P+ +SGTI D SGRTLSGQT EAF S + K
Sbjct: 184 ETIFDTLNAKAAIFAVQQVFEEDAV-ELPIMISGTITDASGRTLSGQTTEAFWNSVRHAK 242
Query: 724 PMAVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFA 903
P++VGLNCALGAKD+R +++ +S +D+ + +PNAGLPNA G YDETP EMA V+ EFA
Sbjct: 243 PISVGLNCALGAKDLRPYLEELSTKADTHVSAHPNAGLPNAFGEYDETPAEMAAVVEEFA 302
Query: 904 RDGLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETNFV 1083
G +NIIGGC GTTP HI A+ +AV PR P+ A + LSGLEP + ++ FV
Sbjct: 303 ASGFLNIIGGCSGTTPGHIQAIAEAVAKYKPREIPEIAKACR--LSGLEPFTIDGQSLFV 360
Query: 1084 NIGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFL 1263
N+GER N+ GS +F LI+ ENY A++VA QV++GAQ++D+NMD+G+LD AM +FL
Sbjct: 361 NVGERTNITGSAKFARLIREENYTEALEVALQQVEAGAQVIDINMDEGMLDSQAAMVRFL 420
Query: 1264 RLISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYG 1443
+I+ EPD++++P+ IDSS +VI AGL+ QGK +VNSIS+KEG E+FK AR+ KRYG
Sbjct: 421 NMIAGEPDISRVPIMIDSSKGEVIEAGLKCIQGKGIVNSISMKEGVEQFKHHARLCKRYG 480
Query: 1444 AAVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSN 1623
AAVVVMAFDE GQA K EIC+RSY IL EVGF P DIIFD NI +ATG+EEH+N
Sbjct: 481 AAVVVMAFDEVGQADTAARKKEICKRSYDILVNEVGFPPEDIIFDPNIFAVATGIEEHNN 540
Query: 1624 YGMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIV 1803
Y + FIEA IR++LP A SGGVSN+SFSFRG +REA+HSVFLF+AI G+ MGIV
Sbjct: 541 YAVDFIEACAYIRDHLPHALTSGGVSNVSFSFRGNNPVREAIHSVFLFHAISNGLTMGIV 600
Query: 1804 NAGALPV 1824
NAG L +
Sbjct: 601 NAGLLEI 607