Homology by BLASTX
BLASTX 2.2.4 [Aug-26-2002]
Query= R13A1_5
(3012 letters)
Database: /home/niguts/usr02/tshini/ykclst/db/nr.seq
1,967,186 sequences; 661,712,633 total letters
Score E
Sequences producing significant alignments: (bits) Value
gi|17541928|ref|NP_501141.1| solute carrier family 12 member (4H... 1880 0.0
gi|39593544|emb|CAE61836.1| Hypothetical protein CBG05808 [Caeno... 1771 0.0
gi|18073139|emb|CAC80545.1| putative Na-K-Cl cotransporter [Melo... 1045 0.0
gi|39596034|emb|CAE67537.1| Hypothetical protein CBG13060 [Caeno... 997 0.0
gi|17534831|ref|NP_495555.1| Na-K-Cl cotransporter (2H716) [Caen... 923 0.0
gi|22026947|ref|NP_571976.2| CG5594-PC [Drosophila melanogaster]... 763 0.0
gi|24762437|ref|NP_726377.1| CG5594-PD [Drosophila melanogaster]... 763 0.0
gi|24762441|ref|NP_726379.1| CG5594-PB [Drosophila melanogaster]... 763 0.0
gi|24762439|ref|NP_726378.1| CG5594-PA [Drosophila melanogaster]... 763 0.0
gi|47522728|ref|NP_999114.1| K-Cl cotransporter [Sus scrofa] >gn... 748 0.0
gi|27151684|sp|Q28677|S124_RABIT Solute carrier family 12 member... 746 0.0
gi|45219767|gb|AAH66872.1| Solute carrier family 12, member 4 [M... 745 0.0
gi|4827006|ref|NP_005063.1| solute carrier family 12 (potassium/... 745 0.0
gi|6677993|ref|NP_033221.1| solute carrier family 12, member 4 [... 745 0.0
gi|31324218|gb|AAP47188.1| potassium-chloride cotransporter-1 [O... 741 0.0
gi|48096020|ref|XP_394587.1| similar to CG5594-PC [Apis mellifera] 738 0.0
gi|9507107|ref|NP_062102.1| solute carrier family 12, member 4 [... 737 0.0
gi|4826780|ref|NP_005126.1| potassium chloride cotransporter KCC... 736 0.0
gi|7512561|pir||T17275 hypothetical protein DKFZp434D2135.1 - hu... 736 0.0
gi|27151690|sp|Q9UHW9|S126_HUMAN Solute carrier family 12 member... 736 0.0
gi|33329254|gb|AAQ10027.1| K-Cl cotransporter KCC3a-S1 isoform [... 736 0.0
gi|19110891|gb|AAL85335.1| K-Cl cotransporter KCC3 variant isofo... 736 0.0
gi|33329252|gb|AAQ10026.1| K-Cl cotransporter KCC3a-X2M isoform ... 736 0.0
gi|6693798|gb|AAF24986.1| K-Cl cotransporter KCC3 [Homo sapiens] 736 0.0
gi|47124056|gb|AAH70107.1| SLC12A6 protein [Homo sapiens] 734 0.0
gi|5730043|ref|NP_006589.1| solute carrier family 12 (potassium/... 731 0.0
gi|41281645|ref|NP_598410.1| solute carrier family 12, member 6 ... 730 0.0
gi|19526769|ref|NP_598409.1| solute carrier family 12, member 6 ... 730 0.0
gi|50733496|ref|XP_418891.1| PREDICTED: similar to mFLJ00098 pro... 724 0.0
gi|32490535|gb|AAP84988.1| potassium-chloride cotransporter isof... 722 0.0
gi|34856648|ref|XP_342490.1| similar to K-Cl cotransporter 3b [R... 719 0.0
gi|3015641|gb|AAC39685.1| erythroid K:Cl cotransporter splicing ... 716 0.0
gi|47847414|dbj|BAD21379.1| mFLJ00098 protein [Mus musculus] 714 0.0
gi|6755534|ref|NP_035520.1| solute carrier family 12, member 7 [... 714 0.0
gi|47213488|emb|CAF91145.1| unnamed protein product [Tetraodon n... 714 0.0
gi|38565928|gb|AAH62099.1| Unknown (protein for MGC:69652) [Mus ... 704 0.0
gi|27151685|sp|Q91V14|S125_MOUSE Solute carrier family 12 member... 701 0.0
gi|28972652|dbj|BAC65742.1| mKIAA1176 protein [Mus musculus] 701 0.0
gi|33859680|ref|NP_065066.1| solute carrier family 12, member 5 ... 701 0.0
gi|3015639|gb|AAC39684.1| erythroid K:Cl cotransporter splicing ... 696 0.0
gi|47225214|emb|CAF98841.1| unnamed protein product [Tetraodon n... 695 0.0
gi|19705463|ref|NP_599190.1| solute carrier family 12 member 5 [... 687 0.0
gi|47223173|emb|CAG11308.1| unnamed protein product [Tetraodon n... 681 0.0
gi|50753670|ref|XP_414082.1| PREDICTED: similar to K-Cl cotransp... 679 0.0
gi|27151688|sp|Q9H2X9|S125_HUMAN Solute carrier family 12 member... 673 0.0
gi|11968148|ref|NP_065759.1| solute carrier family 12 member 5; ... 673 0.0
gi|25149428|ref|NP_500910.2| solute carrier family 12 member, po... 672 0.0
gi|47213000|emb|CAF95392.1| unnamed protein product [Tetraodon n... 665 0.0
gi|6330233|dbj|BAA86490.1| KIAA1176 protein [Homo sapiens] 662 0.0
gi|39584234|emb|CAE61609.1| Hypothetical protein CBG05529 [Caeno... 653 0.0
gi|47220725|emb|CAG11794.1| unnamed protein product [Tetraodon n... 643 0.0
gi|9651224|gb|AAF91094.1| K-Cl cotransporter KCC1 [Mus musculus] 623 e-177
gi|31226974|ref|XP_317803.1| ENSANGP00000014479 [Anopheles gambi... 580 e-164
gi|10440500|dbj|BAB15783.1| FLJ00098 protein [Homo sapiens] 573 e-161
gi|10440514|dbj|BAB15787.1| FLJ00105 protein [Homo sapiens] 573 e-161
gi|34853395|ref|XP_217744.2| similar to putative potassium-chlor... 524 e-147
gi|38637408|dbj|BAD03666.1| putative Na+/K+/Cl-cotransport prote... 430 e-119
gi|31226957|ref|XP_317800.1| ENSANGP00000004794 [Anopheles gambi... 372 e-101
gi|30691713|ref|NP_174333.2| cation-chloride cotransporter, puta... 326 2e-87
gi|25518783|pir||H86428 hypothetical protein F26G16.3 [imported]... 326 2e-87
gi|7489182|pir||T01896 probable Na+/K+/Cl-cotransport protein - ... 320 1e-85
gi|27807511|ref|NP_777207.1| solute carrier family 12 (sodium/po... 270 2e-70
gi|31226979|ref|XP_317804.1| ENSANGP00000024771 [Anopheles gambi... 266 2e-69
gi|47230656|emb|CAF99849.1| unnamed protein product [Tetraodon n... 261 7e-68
gi|13937397|ref|NP_113583.1| solute carrier family 12 (potassium... 246 3e-63
gi|19705533|ref|NP_599232.1| cation-chloride cotransporter 6 [Ra... 243 2e-62
gi|48119195|ref|XP_393214.1| similar to bumetanide sensitive NaK... 241 6e-62
gi|34905658|ref|NP_914176.1| putative cation-chloride co-transpo... 239 3e-61
gi|31236589|ref|XP_319440.1| ENSANGP00000014326 [Anopheles gambi... 238 6e-61
gi|31197669|ref|XP_307782.1| ENSANGP00000012928 [Anopheles gambi... 236 2e-60
gi|24644253|ref|NP_730938.1| CG31547-PB [Drosophila melanogaster... 225 4e-57
gi|24644255|ref|NP_730939.1| CG31547-PA [Drosophila melanogaster... 225 4e-57
gi|50761390|ref|XP_424716.1| PREDICTED: similar to Solute carrie... 224 1e-56
gi|19921484|ref|NP_609887.1| CG10413-PA [Drosophila melanogaster... 216 3e-54
gi|47213642|emb|CAF90346.1| unnamed protein product [Tetraodon n... 212 4e-53
gi|20177071|gb|AAM12297.1| RH37201p [Drosophila melanogaster] 209 3e-52
gi|50727039|gb|AAT81190.1| Hypothetical protein T04B8.5b [Caenor... 206 2e-51
gi|19112532|ref|NP_595740.1| putative membrane transporter [Schi... 206 2e-51
gi|17535967|ref|NP_493773.1| cation-chloride cotransporter-inter... 206 2e-51
gi|39586961|emb|CAE62896.1| Hypothetical protein CBG07084 [Caeno... 206 3e-51
gi|48101446|ref|XP_395129.1| similar to ENSANGP00000014326 [Apis... 205 6e-51
gi|21686581|gb|AAM74964.1| renal Na-K-Cl cotransporter isoform A... 202 3e-50
gi|49094308|ref|XP_408615.1| hypothetical protein AN4478.2 [Aspe... 202 4e-50
gi|5081312|gb|AAD39342.1| bumetanide-sensitive Na-K-2Cl cotransp... 202 4e-50
gi|34879509|ref|XP_346514.1| hypothetical protein XP_346513 [Rat... 202 5e-50
gi|13929130|ref|NP_113986.1| solute carrier family 12, member 2 ... 201 7e-50
gi|47227672|emb|CAG09669.1| unnamed protein product [Tetraodon n... 201 7e-50
gi|40950185|gb|AAR97732.1| Na-K-Cl cotransporter [Oreochromis mo... 201 9e-50
gi|14486416|gb|AAK62044.1| Na+/K+/2Cl- cotransporter [Carcinus m... 201 1e-49
gi|40950183|gb|AAR97731.1| Na-K-Cl cotransporter [Oreochromis mo... 199 3e-49
gi|6179898|gb|AAF05702.1| Na+/K+/2Cl- cotransporter [Callinectes... 199 4e-49
gi|4506975|ref|NP_001037.1| solute carrier family 12 (sodium/pot... 197 1e-48
gi|27652641|emb|CAD31111.1| putative sodium-potassium-chloride c... 197 1e-48
gi|6677991|ref|NP_033220.1| solute carrier family 12, member 2; ... 196 3e-48
gi|27652643|emb|CAD31112.1| putative sodium-potassium-chloride c... 194 1e-47
gi|2136942|pir||I46497 bumetanide-sensitive Na-K-Cl cotransport ... 194 1e-47
gi|13507237|gb|AAK28520.1| K-Cl cotransporter [Xenopus laevis] 194 1e-47
gi|21358517|ref|NP_648572.1| CG4357-PA [Drosophila melanogaster]... 193 2e-47
gi|48893479|ref|ZP_00326715.1| COG0531: Amino acid transporters ... 191 9e-47
gi|47210716|emb|CAF92943.1| unnamed protein product [Tetraodon n... 190 2e-46
gi|21686579|gb|AAM74963.1| renal Na-K-Cl cotransporter isoform A... 190 2e-46
gi|39581643|emb|CAE71764.1| Hypothetical protein CBG18756 [Caeno... 189 3e-46
gi|50752967|ref|XP_413814.1| PREDICTED: similar to bumetanide-se... 189 3e-46
gi|31242251|ref|XP_321556.1| ENSANGP00000011560 [Anopheles gambi... 189 4e-46
gi|40950187|gb|AAR97733.1| Na-K-Cl cotransporter [Oreochromis mo... 188 6e-46
gi|4557849|ref|NP_000329.1| sodium potassium chloride cotranspor... 188 8e-46
gi|17543066|ref|NP_502704.1| solute carrier family 12 member 2 (... 188 8e-46
gi|1709294|sp|P55013|S122_SQUAC Solute carrier family 12 member ... 187 1e-45
gi|45198494|ref|NP_985523.1| AFL025Cp [Eremothecium gossypii] >g... 187 1e-45
gi|2137580|pir||I49269 Na+/K+/Cl-cotransport protein renal splic... 187 1e-45
gi|27151683|sp|P59158|S123_MOUSE Solute carrier family 12 member... 186 4e-45
gi|14547897|ref|NP_062288.1| solute carrier family 12, member 3 ... 186 4e-45
gi|33563368|ref|NP_062218.2| solute carrier family 12, member 3;... 184 8e-45
gi|1083802|pir||B54145 sodium-chloride transporter, Thiazide-sen... 184 8e-45
gi|27151793|sp|P55014|S121_MOUSE Solute carrier family 12 member... 184 1e-44
gi|16877251|gb|AAH16888.1| Solute carrier family 12, member 1, i... 184 1e-44
gi|2290526|gb|AAB65150.1| Na-(K)-Cl cotransporter isoform mBSC1-... 184 1e-44
gi|9507103|ref|NP_062007.1| solute carrier family 12, member 1; ... 184 1e-44
gi|2136943|pir||I46498 bumetanide-sensitive Na-K-Cl cotransport ... 184 1e-44
gi|1709296|sp|P55015|S121_RABIT Solute carrier family 12 member ... 184 1e-44
gi|26343083|dbj|BAC35198.1| unnamed protein product [Mus musculus] 182 3e-44
gi|34365781|ref|NP_899197.1| solute carrier family 12, member 1 ... 182 4e-44
gi|2137581|pir||I49270 Na+/K+/Cl-cotransport protein renal splic... 182 4e-44
gi|50344814|ref|NP_001002080.1| zgc:85961 [Danio rerio] >gnl|BL_... 181 9e-44
gi|21686585|gb|AAM74966.1| renal Na-K-Cl cotransporter isoform A... 179 3e-43
gi|21686589|gb|AAM74968.1| renal Na-K-Cl cotransporter isoform F... 179 3e-43
gi|50423949|ref|XP_460559.1| unnamed protein product [Debaryomyc... 179 3e-43
gi|45527020|ref|ZP_00178221.1| COG0531: Amino acid transporters ... 178 6e-43
gi|10440351|dbj|BAB15711.1| FLJ00010 protein [Homo sapiens] 177 1e-42
gi|31881740|ref|NP_064631.2| solute carrier family 12 (potassium... 177 1e-42
gi|13516498|dbj|BAB40456.1| cation chloride cotransporter 6 [Hom... 177 1e-42
gi|1717801|sp|P55017|S123_HUMAN Solute carrier family 12 member ... 177 1e-42
gi|9502260|gb|AAF88060.1| cation-chloride cotransporter-interact... 176 2e-42
gi|9651629|gb|AAF91220.1| potassium-chloride cotransporter [Mus ... 176 4e-42
gi|47203569|emb|CAG13773.1| unnamed protein product [Tetraodon n... 175 5e-42
gi|7513175|pir||G01202 NaCl electroneutral Thiazide-sensitive co... 175 7e-42
gi|4506977|ref|NP_000330.1| solute carrier family 12 (sodium/chl... 174 1e-41
gi|10440502|dbj|BAB15784.1| FLJ00100 protein [Homo sapiens] 173 3e-41
gi|1717802|sp|P55019|S123_PSEAM Solute carrier family 12 member ... 171 7e-41
gi|16588876|gb|AAL26926.1| thiazide-sensitive Na-Cl cotransporte... 171 7e-41
gi|46446456|ref|YP_007821.1| putative bumetanide-sensitive Na-K-... 171 7e-41
gi|2500792|sp|Q25479|NKCL_MANSE Bumetanide-sensitive sodium-(Pot... 169 5e-40
gi|21686583|gb|AAM74965.1| renal Na-K-Cl cotransporter isoform A... 167 2e-39
gi|21686587|gb|AAM74967.1| renal Na-K-Cl cotransporter isoform F... 167 2e-39
gi|49076498|ref|XP_402217.1| hypothetical protein UM04602.1 [Ust... 166 3e-39
gi|31226967|ref|XP_317802.1| ENSANGP00000015001 [Anopheles gambi... 166 4e-39
gi|38107570|gb|EAA53722.1| hypothetical protein MG09472.4 [Magna... 165 5e-39
gi|13383504|gb|AAK21009.1| cation-chloride cotransporter-interac... 165 7e-39
gi|12652805|gb|AAH00154.1| SLC12A9 protein [Homo sapiens] 165 7e-39
gi|6755532|ref|NP_035519.1| solute carrier family 12, member 1 [... 161 1e-37
gi|2599070|gb|AAC33139.1| thiazide-sensitive sodium chloride cot... 160 2e-37
gi|50753599|ref|XP_414059.1| PREDICTED: similar to solute carrie... 155 4e-36
gi|46121537|ref|XP_385323.1| hypothetical protein FG05147.1 [Gib... 150 1e-34
gi|32404944|ref|XP_323085.1| hypothetical protein ( (AL513466) r... 150 2e-34
gi|32484273|gb|AAH54325.1| LOC398663 protein [Xenopus laevis] 144 1e-32
gi|50545908|ref|XP_500492.1| hypothetical protein [Yarrowia lipo... 143 3e-32
gi|46441644|gb|EAL00940.1| hypothetical protein CaO19.14125 [Can... 130 1e-28
gi|6319712|ref|NP_009794.1| Hypothetical ORF; Ybr235wp [Saccharo... 129 3e-28
gi|20093291|ref|NP_619366.1| Na-K-Cl cotransporter [Methanosarci... 127 1e-27
gi|9651216|gb|AAF91090.1| K-Cl cotransporter [Mus musculus] 126 3e-27
gi|14043556|gb|AAH07760.1| SLC12A7 protein [Homo sapiens] 123 3e-26
gi|3925714|emb|CAA09464.1| KCC2 protein [Mus musculus] 120 3e-25
gi|50778569|ref|XP_427392.1| PREDICTED: similar to solute carrie... 119 4e-25
gi|50292197|ref|XP_448531.1| unnamed protein product [Candida gl... 118 7e-25
gi|50311073|ref|XP_455560.1| unnamed protein product [Kluyveromy... 118 7e-25
gi|50752343|ref|XP_422745.1| PREDICTED: similar to solute carrie... 113 3e-23
gi|1673531|gb|AAB18960.1| furosemide-sensitive K-Cl cotransporte... 110 2e-22
gi|47193414|emb|CAG14039.1| unnamed protein product [Tetraodon n... 108 6e-22
gi|47222533|emb|CAG02898.1| unnamed protein product [Tetraodon n... 108 8e-22
gi|25304083|gb|AAH40138.1| Unknown (protein for MGC:48843) [Homo... 108 8e-22
gi|5759119|gb|AAD50984.1| Na-K-2Cl- cotransporter [Oryctolagus c... 105 5e-21
gi|47224808|emb|CAG06378.1| unnamed protein product [Tetraodon n... 104 1e-20
gi|21748604|dbj|BAC03439.1| FLJ00379 protein [Homo sapiens] 102 5e-20
gi|10440349|dbj|BAB15710.1| FLJ00009 protein [Homo sapiens] 102 5e-20
gi|7512576|pir||T17231 hypothetical protein DKFZp434F076.1 - hum... 100 2e-19
gi|4584410|emb|CAB40708.1| basolateral NaK(2Cl) cotransporter [B... 100 2e-19
gi|2147143|pir||I51307 basolateral Na(+)-K(+)-Cl- cotransporter ... 99 6e-19
gi|1581614|prf||2117156A basolateral Na/K/Cl cotransporter 96 7e-18
gi|34526720|dbj|BAC85271.1| unnamed protein product [Homo sapiens] 94 1e-17
gi|37906389|gb|AAP44496.1| Na-K-Cl cotransporter [Aedes aegypti] 94 2e-17
gi|48102011|ref|XP_392732.1| similar to CG4357-PA [Apis mellifera] 93 3e-17
gi|3582769|gb|AAC35282.1| erythrocyte K-Cl cotransporter [Homo s... 92 6e-17
gi|19527414|ref|NP_599012.1| solute carrier family 12, member 8;... 92 7e-17
gi|31216859|ref|XP_316315.1| ENSANGP00000020551 [Anopheles gambi... 91 1e-16
gi|20892349|ref|XP_147174.1| cation-chloride cotransporter 9 [Mu... 91 2e-16
gi|47226271|emb|CAG09239.1| unnamed protein product [Tetraodon n... 91 2e-16
gi|20128859|ref|NP_569905.1| CG12773-PA [Drosophila melanogaster... 89 5e-16
gi|33327540|gb|AAQ09093.1| SLC12A8 cation-chloride cotransporter... 89 6e-16
gi|50750706|ref|XP_422105.1| PREDICTED: similar to solute carrie... 88 1e-15
gi|15281553|gb|AAK94307.1| solute carrier family 12 member 8 [Ho... 88 1e-15
gi|28628359|gb|AAO49174.1| cation-chloride cotransporter 9 [Homo... 88 1e-15
gi|38569457|ref|NP_078904.3| solute carrier family 12, member 8;... 88 1e-15
gi|21666316|gb|AAM73657.1| solute carrier family 12 member 8 [Ho... 86 5e-15
gi|35505532|gb|AAH57624.1| Slc12a5 protein [Mus musculus] 85 9e-15
gi|23955920|gb|AAN40689.1| putative sodium-potassium-2-chloride ... 84 2e-14
gi|47224809|emb|CAG06379.1| unnamed protein product [Tetraodon n... 84 3e-14
gi|15208177|dbj|BAB63113.1| hypothetical protein [Macaca fascicu... 83 4e-14
gi|2136267|pir||PC4180 thiazide-sensitive sodium-chloride cotran... 80 4e-13
gi|48140542|ref|XP_397130.1| similar to CG12773-PA [Apis mellifera] 79 6e-13
gi|10440446|dbj|BAB15756.1| FLJ00059 protein [Homo sapiens] 71 1e-10
gi|31874120|emb|CAD97969.1| hypothetical protein [Homo sapiens] 71 1e-10
gi|24899633|ref|NP_705889.1| cation-chloride cotransporter 9 [Ra... 70 2e-10
gi|26992100|gb|AAN86742.1| Na-K-Cl cotransporter homolog [Rattus... 70 4e-10
gi|39582293|emb|CAE67542.1| Hypothetical protein CBG13067 [Caeno... 69 9e-10
gi|21411274|gb|AAH30926.1| Slc12a8 protein [Mus musculus] 67 2e-09
gi|4185298|gb|AAD09008.1| Na-K-2Cl cotransporter [Rattus norvegi... 67 3e-09
gi|47013797|gb|AAT08444.1| Na-K-Cl cotransporter isoform 1 [Fund... 66 4e-09
gi|23495278|dbj|BAC20265.1| cation-chloride cotransporter 9 homo... 66 6e-09
gi|17533079|ref|NP_495469.1| cation-chloride cotransporter 9 (2H... 65 7e-09
gi|47013799|gb|AAT08445.1| Na-K-Cl cotransporter isoform 2 [Fund... 65 1e-08
gi|47209879|emb|CAF91324.1| unnamed protein product [Tetraodon n... 65 1e-08
gi|39645560|gb|AAH63528.1| SLC12A8 protein [Homo sapiens] 63 4e-08
gi|46118488|ref|ZP_00175173.2| COG0531: Amino acid transporters ... 62 6e-08
gi|16903173|gb|AAK01946.1| K-Cl cotransporter [Homo sapiens] 62 8e-08
gi|45523845|ref|ZP_00175172.1| COG0531: Amino acid transporters ... 61 2e-07
gi|16974753|gb|AAL32454.1| sodium-potassium-chloride cotransport... 60 3e-07
gi|47216974|emb|CAG04916.1| unnamed protein product [Tetraodon n... 57 3e-06
gi|47180256|emb|CAG13788.1| unnamed protein product [Tetraodon n... 56 5e-06
gi|15604344|ref|NP_220860.1| PUTRESCINE-ORNITHINE ANTIPORTER (po... 55 8e-06
gi|47202119|emb|CAF94384.1| unnamed protein product [Tetraodon n... 55 8e-06
gi|3127109|gb|AAC16048.1| Na-K-Cl cotransporter BSC2 [Rattus nor... 55 1e-05
gi|79644|pir||S06903 hypothetical protein 128 - Synechococcus sp... 53 4e-05
gi|18309319|ref|NP_561253.1| probable amino acid transporter [Cl... 52 1e-04
gi|42518354|ref|NP_964284.1| hypothetical protein LJ0267 [Lactob... 52 1e-04
gi|28377907|ref|NP_784799.1| amino acid transport protein [Lacto... 50 2e-04
gi|48825206|ref|ZP_00286482.1| COG0531: Amino acid transporters ... 50 3e-04
gi|23003339|ref|ZP_00047004.1| COG0531: Amino acid transporters ... 50 3e-04
gi|23024275|ref|ZP_00063492.1| COG0531: Amino acid transporters ... 50 4e-04
gi|15789485|ref|NP_279309.1| cationic amino acid transporter; Ca... 50 4e-04
gi|16801675|ref|NP_471943.1| similar to amino acid transporter [... 49 6e-04
gi|28199142|ref|NP_779456.1| cationic amino acid transporter [Xy... 49 6e-04
gi|47206967|emb|CAF93608.1| unnamed protein product [Tetraodon n... 49 7e-04
gi|38073242|gb|AAR10805.1| K-Cl cotransporter KCC4 [Rattus norve... 49 7e-04
gi|23003192|ref|ZP_00046860.1| COG0531: Amino acid transporters ... 49 7e-04
gi|17540578|ref|NP_502703.1| cotransporter (4O872) [Caenorhabdit... 49 0.001
gi|22997494|ref|ZP_00041724.1| COG0531: Amino acid transporters ... 49 0.001
gi|47212406|emb|CAF92021.1| unnamed protein product [Tetraodon n... 48 0.001
gi|15838798|ref|NP_299486.1| cationic amino acid transporter [Xy... 48 0.001
gi|47222994|emb|CAF99150.1| unnamed protein product [Tetraodon n... 48 0.002
gi|42519815|ref|NP_965745.1| hypothetical protein LJ0510 [Lactob... 48 0.002
gi|16804507|ref|NP_465992.1| similar to amino acid transporter [... 47 0.002
gi|47096061|ref|ZP_00233662.1| amino acid permease family protei... 47 0.002
gi|26342949|dbj|BAC35131.1| unnamed protein product [Mus musculus] 47 0.003
gi|47092755|ref|ZP_00230540.1| amino acid permease family protei... 47 0.004
gi|46908641|ref|YP_015030.1| amino acid permease family protein ... 47 0.004
gi|47216975|emb|CAG04917.1| unnamed protein product [Tetraodon n... 47 0.004
gi|28377701|ref|NP_784593.1| amino acid transport protein (putat... 46 0.005
gi|42520772|ref|NP_966687.1| amino acid permease family protein ... 46 0.005
gi|50753376|ref|XP_413964.1| PREDICTED: similar to bumetanide-se... 46 0.005
gi|47202516|emb|CAF87431.1| unnamed protein product [Tetraodon n... 46 0.006
gi|50753383|ref|XP_425098.1| PREDICTED: similar to Solute carrie... 46 0.006
gi|24111869|ref|NP_706379.1| putative amino acid-amine transport... 46 0.006
gi|16128470|ref|NP_415019.1| putative amino acid/amine transport... 46 0.006
gi|4584408|emb|CAB40707.1| apical Na(2Cl)K cotransporter [Bos ta... 45 0.008
gi|48852298|ref|ZP_00306486.1| COG0531: Amino acid transporters ... 45 0.010
gi|39581644|emb|CAE71765.1| Hypothetical protein CBG18757 [Caeno... 45 0.010
gi|15892649|ref|NP_360363.1| putrescine-ornithine antiporter [Ri... 45 0.010
gi|34581603|ref|ZP_00143083.1| putrescine-ornithine antiporter [... 45 0.010
gi|47201162|emb|CAF87719.1| unnamed protein product [Tetraodon n... 44 0.018
gi|39645063|gb|AAH63720.1| LOC399077 protein [Xenopus laevis] 44 0.018
gi|15668789|ref|NP_247591.1| amino acid transporter [Methanocald... 44 0.018
gi|16077801|ref|NP_388615.1| yfnA [Bacillus subtilis subsp. subt... 44 0.023
gi|50746939|ref|XP_420685.1| PREDICTED: similar to cationic amin... 44 0.023
gi|2116759|dbj|BAA20110.1| YfnA [Bacillus subtilis] 44 0.023
gi|31321986|gb|AAM48576.1| RHAG-2 [Takifugu rubripes] 44 0.023
gi|48852342|ref|ZP_00306530.1| COG0531: Amino acid transporters ... 44 0.030
gi|21231270|ref|NP_637187.1| cationic amino acid transporter [Xa... 44 0.030
gi|42519812|ref|NP_965742.1| hypothetical protein LJ0513 [Lactob... 44 0.030
gi|15800215|ref|NP_286227.1| putative amino acid/amine transport... 44 0.030
gi|15924427|ref|NP_371961.1| hypothetical protein SAV1437 [Staph... 43 0.039
gi|26246501|ref|NP_752540.1| Hypothetical transport protein ybaT... 43 0.039
gi|23472012|ref|ZP_00127340.1| COG0531: Amino acid transporters ... 43 0.052
gi|48894344|ref|ZP_00327453.1| COG0531: Amino acid transporters ... 43 0.052
gi|29375513|ref|NP_814667.1| amino acid permease family protein ... 43 0.052
gi|46107025|ref|ZP_00188281.2| COG0531: Amino acid transporters ... 43 0.052
gi|17548503|ref|NP_521843.1| PROBABLE AMINO-ACID PERMEASE TRANSM... 43 0.052
gi|4507049|ref|NP_003037.1| solute carrier family 7 (cationic am... 42 0.067
gi|41408191|ref|NP_961027.1| RocE [Mycobacterium avium subsp. pa... 42 0.067
gi|46311818|ref|ZP_00212420.1| COG0531: Amino acid transporters ... 42 0.067
gi|29653772|ref|NP_819464.1| amino acid permease family protein ... 42 0.067
gi|21242586|ref|NP_642168.1| cationic amino acid transporter [Xa... 42 0.088
gi|12018302|ref|NP_072141.1| cationic amino acid transporter-2A;... 42 0.088
gi|46446561|ref|YP_007926.1| putative cationic amino acid transp... 42 0.088
gi|6671598|ref|NP_031540.1| solute carrier family 7 (cationic am... 42 0.088
gi|46142110|ref|ZP_00204157.1| COG0531: Amino acid transporters ... 42 0.11
gi|23003196|ref|ZP_00046864.1| COG0531: Amino acid transporters ... 42 0.11
gi|32471166|ref|NP_864159.1| amino acid transporter [Pirellula s... 42 0.11
gi|46321300|ref|ZP_00221678.1| COG0531: Amino acid transporters ... 42 0.11
gi|34496326|ref|NP_900541.1| probable amino-acid permease transm... 42 0.11
gi|50417792|gb|AAH78099.1| Unknown (protein for MGC:83504) [Xeno... 42 0.11
gi|48781660|ref|ZP_00278251.1| COG0531: Amino acid transporters ... 41 0.15
gi|21398550|ref|NP_654535.1| aa_permeases, Amino acid permease [... 41 0.20
gi|15841825|ref|NP_336862.1| amino acid permease [Mycobacterium ... 41 0.20
gi|15609457|ref|NP_216836.1| rocE [Mycobacterium tuberculosis H3... 41 0.20
gi|16077281|ref|NP_388094.1| ybeC [Bacillus subtilis subsp. subt... 41 0.20
gi|39581389|emb|CAE69286.1| Hypothetical protein CBG15341 [Caeno... 41 0.20
gi|2353183|gb|AAB69390.1| CtrA [Dictyostelium discoideum] 41 0.20
gi|15902949|ref|NP_358499.1| Cationic amino acid transporter - A... 41 0.20
gi|48826042|ref|ZP_00287270.1| COG0531: Amino acid transporters ... 41 0.20
gi|16081855|ref|NP_394251.1| amino acid transport protein relate... 41 0.20
gi|24430322|emb|CAD10673.1| putative Na/K/2Cl cotransporter [Sal... 41 0.20
gi|24430324|emb|CAD10674.1| putative Na/K/2Cl cotransporter [Sal... 41 0.20
gi|39933664|ref|NP_945940.1| putative cationic amino acid transp... 40 0.26
gi|22297799|ref|NP_681046.1| amino acid permease family protein ... 40 0.26
gi|48870773|ref|ZP_00323492.1| COG0531: Amino acid transporters ... 40 0.26
gi|41409463|ref|NP_962299.1| hypothetical protein MAP3365c [Myco... 40 0.26
gi|6006869|gb|AAF00645.1| putative cationic amino acid transport... 40 0.26
gi|22330822|ref|NP_187022.2| amino acid permease family protein ... 40 0.26
gi|14530223|gb|AAK65959.1| putative cationic aminoacid transport... 40 0.33
gi|15900874|ref|NP_345478.1| amino acid permease family protein ... 40 0.33
gi|20372849|emb|CAC82478.1| cationic amino acid transporter 2B [... 40 0.44
gi|23306414|gb|AAN17434.1| Unknown protein [Arabidopsis thaliana] 40 0.44
gi|47567173|ref|ZP_00237889.1| amino acid permease [Bacillus cer... 40 0.44
gi|30693001|ref|NP_198510.2| amino acid permease family protein ... 39 0.57
gi|15790298|ref|NP_280122.1| amino acid transporter; YhdG [Halob... 39 0.57
gi|29376558|ref|NP_815712.1| amino acid permease family protein ... 39 0.57
gi|10178213|dbj|BAB11637.1| cationic amino acid transporter-like... 39 0.57
gi|23025053|ref|ZP_00064232.1| COG0531: Amino acid transporters ... 39 0.57
gi|30696198|ref|NP_849822.1| amino acid permease family protein ... 39 0.57
gi|46854889|gb|AAH69648.1| SLC7A2 protein [Homo sapiens] 39 0.57
gi|1297194|gb|AAC52813.1| RCAT2 39 0.57
gi|2183088|gb|AAB60867.1| high affinity cationic amino acid tran... 39 0.57
gi|15803883|ref|NP_289918.1| putative amino acid/amine transport... 39 0.74
gi|16131248|ref|NP_417829.1| putative amino acid/amine transport... 39 0.74
gi|606304|gb|AAA58167.1| ORF_o462 [Escherichia coli] 39 0.74
gi|111130|pir||A35674 Tea protein - mouse 39 0.74
gi|27469133|ref|NP_765770.1| arginine/oirnithine antiporter [Sta... 39 0.74
gi|20372850|emb|CAC82479.1| cationic amino acid transporter 2A [... 39 0.74
gi|48851964|ref|ZP_00306157.1| COG0531: Amino acid transporters ... 39 0.74
gi|37999732|sp|Q8X845|FRLA_ECO57 Putative fructoselysine transpo... 39 0.74
gi|2851642|sp|P45539|FRLA_ECOLI Putative fructoselysine transpor... 39 0.74
gi|29244640|gb|AAO73233.1| putative cationic amino acid transpor... 39 0.74
gi|476725|gb|AAA75250.1| T-cell early activation protein 39 0.74
gi|21673751|ref|NP_661816.1| amino acid permease [Chlorobium tep... 39 0.97
gi|16078011|ref|NP_388827.1| yhdG [Bacillus subtilis subsp. subt... 39 0.97
gi|29653703|ref|NP_819395.1| amino acid permease family protein ... 39 0.97
gi|23612727|ref|NP_704266.1| hypothetical protein [Plasmodium fa... 39 0.97
gi|20807215|ref|NP_622386.1| Amino acid transporters [Thermoanae... 39 0.97
gi|22993680|ref|ZP_00038237.1| COG0531: Amino acid transporters ... 39 0.97
gi|37534696|ref|NP_921650.1| putative cationic amino acid transp... 39 0.97
gi|50260562|gb|EAL23217.1| hypothetical protein CNBA5610 [Crypto... 39 0.97
gi|48854106|ref|ZP_00308270.1| COG0531: Amino acid transporters ... 38 1.3
gi|27503400|gb|AAH42222.1| Slc7a3-prov protein [Xenopus laevis] 38 1.3
gi|48851858|ref|ZP_00306053.1| COG0531: Amino acid transporters ... 38 1.3
gi|29840258|ref|NP_829364.1| amino acid antiporter [Chlamydophil... 38 1.3
gi|42518101|ref|NP_964031.1| hypothetical protein LJ0016 [Lactob... 38 1.7
gi|37521235|ref|NP_924612.1| probable amino acid transporter [Gl... 38 1.7
gi|15598793|ref|NP_252287.1| probable amino acid permease [Pseud... 38 1.7
gi|47219273|emb|CAG11735.1| unnamed protein product [Tetraodon n... 38 1.7
gi|15610389|ref|NP_217770.1| hypothetical protein Rv3253c [Mycob... 38 1.7
gi|16799723|ref|NP_469991.1| similar to amino acid transporter [... 38 1.7
gi|47568938|ref|ZP_00239630.1| amino acid permease [Bacillus cer... 38 1.7
gi|29828785|ref|NP_823419.1| putative cationic amino acid transp... 38 1.7
gi|27467023|ref|NP_763660.1| arginine/oirnithine antiporter [Sta... 37 2.2
gi|46164323|ref|ZP_00136987.2| COG0531: Amino acid transporters ... 37 2.2
gi|13541636|ref|NP_111324.1| Amino acid transporter [Thermoplasm... 37 2.2
gi|23336841|ref|ZP_00121987.1| COG0531: Amino acid transporters ... 37 2.2
gi|585115|sp|Q08354|EZY1_CHLRE Ezy-1 protein precursor >gnl|BL_O... 37 2.2
gi|21226632|ref|NP_632554.1| Amino acid permease [Methanosarcina... 37 2.2
gi|23466114|ref|NP_696717.1| possible cationic amino acid transp... 37 2.2
gi|30021678|ref|NP_833309.1| Amino acid permease [Bacillus cereu... 37 2.2
gi|21233103|ref|NP_639020.1| amino acid transporter [Xanthomonas... 37 2.2
gi|48478581|ref|YP_024287.1| amino acid permease [Picrophilus to... 37 2.2
gi|1706188|sp|P52569|CTR2_HUMAN Low-affinity cationic amino acid... 37 2.2
gi|29828860|ref|NP_823494.1| putative amino acid permease [Strep... 37 2.8
gi|16802085|ref|NP_463570.1| similar to amino acid transporter [... 37 2.8
gi|42561228|ref|NP_975679.1| Amino acid transporter [Mycoplasma ... 37 2.8
gi|46323781|ref|ZP_00224144.1| COG0531: Amino acid transporters ... 37 2.8
gi|48784151|ref|ZP_00280532.1| COG0531: Amino acid transporters ... 37 2.8
gi|48840136|ref|ZP_00297064.1| COG0531: Amino acid transporters ... 37 2.8
gi|47095105|ref|ZP_00232717.1| amino acid permease family protei... 37 2.8
gi|48852485|ref|ZP_00306671.1| COG0531: Amino acid transporters ... 37 2.8
gi|48826405|ref|ZP_00287615.1| COG0531: Amino acid transporters ... 35 3.4
gi|46906268|ref|YP_012657.1| amino acid permease family protein ... 37 3.7
gi|2126237|pir||JC5086 polytopic cytoplasmic membrane protein - ... 37 3.7
gi|47092162|ref|ZP_00229954.1| amino acid permease family protei... 37 3.7
gi|15675845|ref|NP_270019.1| putative cationic amino acid transp... 37 3.7
gi|49236175|ref|ZP_00330236.1| COG0531: Amino acid transporters ... 37 3.7
gi|28377721|ref|NP_784613.1| amino acid transport protein [Lacto... 37 3.7
gi|42453850|ref|ZP_00153757.1| hypothetical protein Rick071801 [... 37 3.7
gi|7530144|emb|CAB86885.1| putative Na/K/2Cl cotransporter [Scyl... 37 3.7
gi|47223172|emb|CAG11307.1| unnamed protein product [Tetraodon n... 37 3.7
gi|48824294|ref|ZP_00285688.1| COG0531: Amino acid transporters ... 37 3.7
gi|29655083|ref|NP_820775.1| amino acid permease family protein ... 37 3.7
gi|28950241|emb|CAD71108.1| related to GABA transport protein [N... 36 4.8
gi|30018779|ref|NP_830410.1| Alanine permease [Bacillus cereus A... 36 4.8
gi|42783142|ref|NP_980389.1| amino acid permease [Bacillus cereu... 36 4.8
gi|32413963|ref|XP_327461.1| hypothetical protein [Neurospora cr... 36 4.8
gi|21911314|ref|NP_665582.1| putative cationic amino acid transp... 36 4.8
gi|29828835|ref|NP_823469.1| putative amino acid permease [Strep... 36 4.8
gi|15898834|ref|NP_343439.1| Amino acid transporter related prot... 36 4.8
gi|47227115|emb|CAG00477.1| unnamed protein product [Tetraodon n... 36 4.8
gi|21244442|ref|NP_644024.1| amino acid transporter [Xanthomonas... 36 4.8
gi|42518643|ref|NP_964573.1| hypothetical protein LJ0721 [Lactob... 36 4.8
gi|49091126|ref|XP_407024.1| hypothetical protein AN2887.2 [Aspe... 36 4.8
gi|11692699|gb|AAG39938.1| Na+/K+/2Cl- cotransporter [Eriocheir ... 36 6.3
gi|27365192|ref|NP_760720.1| Putative p-aminobenzoyl-glutamate t... 36 6.3
gi|19746960|ref|NP_608096.1| putative cationic amino acid transp... 36 6.3
gi|48112037|ref|XP_393144.1| similar to CG11128-PC [Apis mellifera] 36 6.3
gi|6321361|ref|NP_011438.1| Choline transporter (permease) that ... 36 6.3
gi|23002734|ref|ZP_00046407.1| COG0531: Amino acid transporters ... 36 6.3
gi|48838069|ref|ZP_00295019.1| COG0531: Amino acid transporters ... 35 8.2
gi|21242585|ref|NP_642167.1| cationic amino acid transporter [Xa... 35 8.2
gi|21244588|ref|NP_644170.1| cationic amino acid transporter [Xa... 35 8.2
gi|31793158|ref|NP_855651.1| POSSIBLE CONSERVED PERMEASE [Mycoba... 35 8.2
>gi|17541928|ref|NP_501141.1| solute carrier family 12 member (4H981)
[Caenorhabditis elegans]
gi|7506700|pir||T16740 hypothetical protein R13A1.2 - Caenorhabditis
elegans
gi|1065932|gb|AAA81476.1| Temporarily assigned gene name protein 158
[Caenorhabditis elegans]
Length = 1003
Score = 1880 bits (4869), Expect = 0.0
Identities = 948/1003 (94%), Positives = 948/1003 (94%)
Frame = +1
Query: 1 MPFFSSYLKAHITPGPLERAQSSSHGGHGAKADLGVLLGVYLPTIQHILGVTMFIRLFWL 180
MPFFSSYLKAHITPGPLERAQSSSHGGHGAKADLGVLLGVYLPTIQHILGVTMFIRLFWL
Sbjct: 1 MPFFSSYLKAHITPGPLERAQSSSHGGHGAKADLGVLLGVYLPTIQHILGVTMFIRLFWL 60
Query: 181 VGIAGLGQXXXXXXXXXXXXXXXXISISAVATNGVVESGGAYFMISRNLGPEFGSAVGIL 360
VGIAGLGQ ISISAVATNGVVESGGAYFMISRNLGPEFGSAVGIL
Sbjct: 61 VGIAGLGQTFLLLFLCCFCTFLTCISISAVATNGVVESGGAYFMISRNLGPEFGSAVGIL 120
Query: 361 FYLANTVATSMYLVGGVEILLLYIFPGLTFGGVEGQHDTSMFGTMTNSLRFYSTILLLIE 540
FYLANTVATSMYLVGGVEILLLYIFPGLTFGGVEGQHDTSMFGTMTNSLRFYSTILLLIE
Sbjct: 121 FYLANTVATSMYLVGGVEILLLYIFPGLTFGGVEGQHDTSMFGTMTNSLRFYSTILLLIE 180
Query: 541 FAIVAMGVKFVQMLAPVSLVCVILSILACYAGGVTKTIYPDSGQYVCMYNDRLLQSSAVL 720
FAIVAMGVKFVQMLAPVSLVCVILSILACYAGGVTKTIYPDSGQYVCMYNDRLLQSSAVL
Sbjct: 181 FAIVAMGVKFVQMLAPVSLVCVILSILACYAGGVTKTIYPDSGQYVCMYNDRLLQSSAVL 240
Query: 721 NESIPLDEICNYCNINNTFLADRVCGGRCNSTTIPHVSPFRCINGFPGFQGGQTLLENLG 900
NESIPLDEICNYCNINNTFLADRVCGGRCNSTTIPHVSPFRCINGFPGFQGGQTLLENLG
Sbjct: 241 NESIPLDEICNYCNINNTFLADRVCGGRCNSTTIPHVSPFRCINGFPGFQGGQTLLENLG 300
Query: 901 PNYLEKGEAAHGTQADTKSDVYQDVRTSFFVLLAIYFPAVTGIFTGANMSGDLKNPQASI 1080
PNYLEKGEAAHGTQADTKSDVYQDVRTSFFVLLAIYFPAVTGIFTGANMSGDLKNPQASI
Sbjct: 301 PNYLEKGEAAHGTQADTKSDVYQDVRTSFFVLLAIYFPAVTGIFTGANMSGDLKNPQASI 360
Query: 1081 PAGTIAANLTTSFVYFSLAFIFGGAIDNAVLRDKNGQSVGGQMVVALLSWPSPWVLLIGS 1260
PAGTIAANLTTSFVYFSLAFIFGGAIDNAVLRDKNGQSVGGQMVVALLSWPSPWVLLIGS
Sbjct: 361 PAGTIAANLTTSFVYFSLAFIFGGAIDNAVLRDKNGQSVGGQMVVALLSWPSPWVLLIGS 420
Query: 1261 FLSTFGAALQCLCSAPRLLQAIAKDEVIPLLSPFKKVTANNEPFXXXXXXXXXXXXXXXM 1440
FLSTFGAALQCLCSAPRLLQAIAKDEVIPLLSPFKKVTANNEPF M
Sbjct: 421 FLSTFGAALQCLCSAPRLLQAIAKDEVIPLLSPFKKVTANNEPFLGLILTTIIAEIAILM 480
Query: 1441 GSMDTIAAVVDFFFLMCYAFVNIICTLHSLLGAPNWRPRFKYYHWFLSLLGAVLCFFIMF 1620
GSMDTIAAVVDFFFLMCYAFVNIICTLHSLLGAPNWRPRFKYYHWFLSLLGAVLCFFIMF
Sbjct: 481 GSMDTIAAVVDFFFLMCYAFVNIICTLHSLLGAPNWRPRFKYYHWFLSLLGAVLCFFIMF 540
Query: 1621 STHWDYAIVACLLCLVIYKYVEWKGAKKEWGDGIRGLALTTAQYSLMKIEDKEPHPKNWR 1800
STHWDYAIVACLLCLVIYKYVEWKGAKKEWGDGIRGLALTTAQYSLMKIEDKEPHPKNWR
Sbjct: 541 STHWDYAIVACLLCLVIYKYVEWKGAKKEWGDGIRGLALTTAQYSLMKIEDKEPHPKNWR 600
Query: 1801 PQLLLLLSMQWSKEIIDVRYLNLLNLASQLKAGKGLTVVTAFLQGDPTSPDDKKKGEQVK 1980
PQLLLLLSMQWSKEIIDVRYLNLLNLASQLKAGKGLTVVTAFLQGDPTSPDDKKKGEQVK
Sbjct: 601 PQLLLLLSMQWSKEIIDVRYLNLLNLASQLKAGKGLTVVTAFLQGDPTSPDDKKKGEQVK 660
Query: 1981 ARMDFDMNQVRLRGFAKTLVHSEDQVRGSMSTLVQSVGLGGLKPNTMLISWPVHEREEDM 2160
ARMDFDMNQVRLRGFAKTLVHSEDQVRGSMSTLVQSVGLGGLKPNTMLISWPVHEREEDM
Sbjct: 661 ARMDFDMNQVRLRGFAKTLVHSEDQVRGSMSTLVQSVGLGGLKPNTMLISWPVHEREEDM 720
Query: 2161 TEYNTFIEKVHAASINDMAIVVAKGIIDFPSAVFRMSGMIDVYWIVHDGGLCLLMGYLLK 2340
TEYNTFIEKVHAASINDMAIVVAKGIIDFPSAVFRMSGMIDVYWIVHDGGLCLLMGYLLK
Sbjct: 721 TEYNTFIEKVHAASINDMAIVVAKGIIDFPSAVFRMSGMIDVYWIVHDGGLCLLMGYLLK 780
Query: 2341 QHKVWRGCKLRVIGIAQESDNNVKMQEDLQKYVYQLRIDAKIMIVELADPEISKNAFERT 2520
QHKVWRGCKLRVIGIAQESDNNVKMQEDLQKYVYQLRIDAKIMIVELADPEISKNAFERT
Sbjct: 781 QHKVWRGCKLRVIGIAQESDNNVKMQEDLQKYVYQLRIDAKIMIVELADPEISKNAFERT 840
Query: 2521 LLMEERTMMMRDLQKVSGGGMSLSLPPANAPRAPSPLVTSERRANSKXXXXXXXXXXXXX 2700
LLMEERTMMMRDLQKVSGGGMSLSLPPANAPRAPSPLVTSERRANSK
Sbjct: 841 LLMEERTMMMRDLQKVSGGGMSLSLPPANAPRAPSPLVTSERRANSKDSDEGTPTESEET 900
Query: 2701 XXXXXXXXXXXQANQETKTKKERMKALDRSKVSKMHTAVRLNELLLQHSANSQLILLNLP 2880
QANQETKTKKERMKALDRSKVSKMHTAVRLNELLLQHSANSQLILLNLP
Sbjct: 901 TEKKSTSTDNEQANQETKTKKERMKALDRSKVSKMHTAVRLNELLLQHSANSQLILLNLP 960
Query: 2881 KPPVHKDQQALDDYVHYLEVMTDKLNRVIFVRGTGKEVITESS 3009
KPPVHKDQQALDDYVHYLEVMTDKLNRVIFVRGTGKEVITESS
Sbjct: 961 KPPVHKDQQALDDYVHYLEVMTDKLNRVIFVRGTGKEVITESS 1003
>gi|39593544|emb|CAE61836.1| Hypothetical protein CBG05808
[Caenorhabditis briggsae]
Length = 1002
Score = 1771 bits (4588), Expect = 0.0
Identities = 897/1004 (89%), Positives = 918/1004 (91%), Gaps = 1/1004 (0%)
Frame = +1
Query: 1 MPFFSSYLKAHITPGPLERAQSSSHGGHGAKADLGVLLGVYLPTIQHILGVTMFIRLFWL 180
MPFFSSYLKAHITPGPLERAQSSSHGGHG KADLGVLLGVYLPTIQHILGVTMFIRLFWL
Sbjct: 1 MPFFSSYLKAHITPGPLERAQSSSHGGHGGKADLGVLLGVYLPTIQHILGVTMFIRLFWL 60
Query: 181 VGIAGLGQXXXXXXXXXXXXXXXXISISAVATNGVVESGGAYFMISRNLGPEFGSAVGIL 360
VGIAGLGQ ISISAVATNGVVESGGAYFMISRNLGPEFGSAVGIL
Sbjct: 61 VGIAGLGQTFLLLFLCCFCTFLTCISISAVATNGVVESGGAYFMISRNLGPEFGSAVGIL 120
Query: 361 FYLANTVATSMYLVGGVEILLLYIFPGLTFGGVEGQHDTSMFGTMTNSLRFYSTILLLIE 540
FYLANTVATSMYLVGGVEILLLYIFPGLTFGG +GQHDTS+FGTMTNSLRFYSTILLLIE
Sbjct: 121 FYLANTVATSMYLVGGVEILLLYIFPGLTFGGSDGQHDTSLFGTMTNSLRFYSTILLLIE 180
Query: 541 FAIVAMGVKFVQMLAPVSLVCVILSILACYAGGVTKTIYPDSGQYVCMYNDRLLQSSAVL 720
FAIVAMGVKFVQMLAPVSL+CVILSILACYAGG TKT+YPDSGQYVCM+N+RLLQSSA+
Sbjct: 181 FAIVAMGVKFVQMLAPVSLICVILSILACYAGGATKTMYPDSGQYVCMFNERLLQSSALH 240
Query: 721 NESIPLDEICNYCNINNTFLADRVCGGR-CNSTTIPHVSPFRCINGFPGFQGGQTLLENL 897
NE++ LD+IC YCN NNT+L D+VCG CN T + F CINGFPGFQGG+TLL NL
Sbjct: 241 NETVALDDICGYCNNNNTYLLDKVCGPEGCNDTMLAR-GGFSCINGFPGFQGGKTLLNNL 299
Query: 898 GPNYLEKGEAAHGTQADTKSDVYQDVRTSFFVLLAIYFPAVTGIFTGANMSGDLKNPQAS 1077
GPNYL K +AA G AD K DVYQDVRT+FFVLLAIYFPAVTGIFTGANMSGDLKNPQAS
Sbjct: 300 GPNYLAKNQAAVGIPADLKVDVYQDVRTTFFVLLAIYFPAVTGIFTGANMSGDLKNPQAS 359
Query: 1078 IPAGTIAANLTTSFVYFSLAFIFGGAIDNAVLRDKNGQSVGGQMVVALLSWPSPWVLLIG 1257
IPAGTIAANLTTSF+YFSLAFIFGGAID AVLRDKNGQSVGGQMVVALLSWPSPWVLLIG
Sbjct: 360 IPAGTIAANLTTSFIYFSLAFIFGGAIDGAVLRDKNGQSVGGQMVVALLSWPSPWVLLIG 419
Query: 1258 SFLSTFGAALQCLCSAPRLLQAIAKDEVIPLLSPFKKVTANNEPFXXXXXXXXXXXXXXX 1437
SFLSTFGAALQCLCSAPRLLQAIAKDEVIP+LSPFKKVTANNEPF
Sbjct: 420 SFLSTFGAALQCLCSAPRLLQAIAKDEVIPILSPFKKVTANNEPFLGLILTTVIAEIAIL 479
Query: 1438 MGSMDTIAAVVDFFFLMCYAFVNIICTLHSLLGAPNWRPRFKYYHWFLSLLGAVLCFFIM 1617
MGSMDTIAAVVDFFFLMCYAFVNIICTLHSLLGAPNWRPRFKYYHWFLSLLGAVLCFFIM
Sbjct: 480 MGSMDTIAAVVDFFFLMCYAFVNIICTLHSLLGAPNWRPRFKYYHWFLSLLGAVLCFFIM 539
Query: 1618 FSTHWDYAIVACLLCLVIYKYVEWKGAKKEWGDGIRGLALTTAQYSLMKIEDKEPHPKNW 1797
FSTHWDYAIVACLLCLVIYKYVEWKGAKKEWGDGIRGLALTTAQYSLMKIEDKEPHPKNW
Sbjct: 540 FSTHWDYAIVACLLCLVIYKYVEWKGAKKEWGDGIRGLALTTAQYSLMKIEDKEPHPKNW 599
Query: 1798 RPQLLLLLSMQWSKEIIDVRYLNLLNLASQLKAGKGLTVVTAFLQGDPTSPDDKKKGEQV 1977
RPQLLLLLSMQWSKEIIDVRYLNLLNLASQLKAGKGLTVVTAFL+GDPTSPDDKKKGEQV
Sbjct: 600 RPQLLLLLSMQWSKEIIDVRYLNLLNLASQLKAGKGLTVVTAFLKGDPTSPDDKKKGEQV 659
Query: 1978 KARMDFDMNQVRLRGFAKTLVHSEDQVRGSMSTLVQSVGLGGLKPNTMLISWPVHEREED 2157
KARMDFDMNQVRLRGFAKTLVHSEDQVRGSMSTLVQSVGLGGLKPNTMLISWPVHEREED
Sbjct: 660 KARMDFDMNQVRLRGFAKTLVHSEDQVRGSMSTLVQSVGLGGLKPNTMLISWPVHEREED 719
Query: 2158 MTEYNTFIEKVHAASINDMAIVVAKGIIDFPSAVFRMSGMIDVYWIVHDGGLCLLMGYLL 2337
MTEYNTFIEKVHAASINDMAIVVAKGIIDFPSAVFRMSGMIDVYWIVHDGGLCLLMGYLL
Sbjct: 720 MTEYNTFIEKVHAASINDMAIVVAKGIIDFPSAVFRMSGMIDVYWIVHDGGLCLLMGYLL 779
Query: 2338 KQHKVWRGCKLRVIGIAQESDNNVKMQEDLQKYVYQLRIDAKIMIVELADPEISKNAFER 2517
KQHKVWRGCKLRVIGIAQESDNNVKMQEDLQKYVYQLRIDAKIMIVELADPEISKNAFER
Sbjct: 780 KQHKVWRGCKLRVIGIAQESDNNVKMQEDLQKYVYQLRIDAKIMIVELADPEISKNAFER 839
Query: 2518 TLLMEERTMMMRDLQKVSGGGMSLSLPPANAPRAPSPLVTSERRANSKXXXXXXXXXXXX 2697
TLLMEERTMMMRDLQKVSGGGM+LSLPP NAPRA SPLVTSE+R NSK
Sbjct: 840 TLLMEERTMMMRDLQKVSGGGMTLSLPP-NAPRAVSPLVTSEKRENSKDSDEGTTTGSEE 898
Query: 2698 XXXXXXXXXXXXQANQETKTKKERMKALDRSKVSKMHTAVRLNELLLQHSANSQLILLNL 2877
QANQETKTKKERMKALDRSKVSKMHTAVRLNELLLQHSANSQLILLNL
Sbjct: 899 TLDKKSPTTDNEQANQETKTKKERMKALDRSKVSKMHTAVRLNELLLQHSANSQLILLNL 958
Query: 2878 PKPPVHKDQQALDDYVHYLEVMTDKLNRVIFVRGTGKEVITESS 3009
PKPPVHKDQQALDDYVHYLEVMTDKLNRVIFVRGTGKEVITESS
Sbjct: 959 PKPPVHKDQQALDDYVHYLEVMTDKLNRVIFVRGTGKEVITESS 1002
>gi|18073139|emb|CAC80545.1| putative Na-K-Cl cotransporter
[Meloidogyne incognita]
Length = 1082
Score = 1045 bits (2702), Expect = 0.0
Identities = 553/1017 (54%), Positives = 711/1017 (69%), Gaps = 18/1017 (1%)
Frame = +1
Query: 13 SSYLKAHITPGPLERAQSSSHGGHGAKADLGVLLGVYLPTIQHILGVTMFIRLFWLVGIA 192
+S++ A+ TPGP ERA + KA+LGV+ GVYLPTIQHILGVTMFIRLFW+VG+A
Sbjct: 81 ASFISAYTTPGPKERATCAKK-----KANLGVMFGVYLPTIQHILGVTMFIRLFWVVGVA 135
Query: 193 GLGQXXXXXXXXXXXXXXXXISISAVATNGVVESGGAYFMISRNLGPEFGSAVGILFYLA 372
G+ IS+SAVATNGVVE GGAYFMISRNLG EFGSAVGILFYLA
Sbjct: 136 GVWHTMLLLFLCCTCTLLTCISLSAVATNGVVEGGGAYFMISRNLGAEFGSAVGILFYLA 195
Query: 373 NTVATSMYLVGGVEILLLYIFPGLTFGGVEGQHDTSMFGTMTNSLRFYSTILLLIEFAIV 552
NTVATSMYLVGGVE+ LLYI P LT GG E DT M G M+N+ R Y T+LLLIE IV
Sbjct: 196 NTVATSMYLVGGVEVFLLYIHPSLTIGGEEVHSDTGMLGMMSNNYRIYGTLLLLIECVIV 255
Query: 553 AMGVKFVQMLAPVSLVCVILSILACYAGGVTKTIYPDSGQYVCMYNDRLLQSSAVLNESI 732
A+GV+FVQ+LAPVSL+CVILSI+AC+AGG+ K I +GQ+VCM D LL SS VLN I
Sbjct: 256 ALGVRFVQLLAPVSLLCVILSIMACFAGGIEKAI-TYNGQHVCMLEDHLL-SSRVLN--I 311
Query: 733 PLDE----ICNYCNINNTFLADRVCGGRCNSTTIPHVSP--FRCINGFPGFQGGQTLLEN 894
P E IC+YC +AD C G + + RC+N FPGF L +N
Sbjct: 312 PHHEDIANICDYCK-KGDHIADEFCEGNATTEVCQTYTGGNLRCVNAFPGFNS-LILTQN 369
Query: 895 LGPNYLEKGEAAHGTQ-ADTKSDVYQDVRTSFFVLLAIYFPAVTGIFTGANMSGDLKNPQ 1071
+ YL+ G+A + AD +VYQDV TSFF+LLAIYFPAVTGI TGANMSGDLK+PQ
Sbjct: 370 MDSVYLQAGQAILRERVADKAREVYQDVTTSFFLLLAIYFPAVTGIMTGANMSGDLKDPQ 429
Query: 1072 ASIPAGTIAANLTTSFVYFSLAFIFGGAIDNAVLRDKNGQSVGGQMVVALLSWPSPWVLL 1251
SIP+GT+AA LTTSF+Y +LA +FG +I VLRDKNG+S+ G +VVA LSWPSPWV++
Sbjct: 430 RSIPSGTVAATLTTSFIYVALAILFGCSIIGPVLRDKNGKSLDGSLVVASLSWPSPWVVI 489
Query: 1252 IGSFLSTFGAALQCLCSAPRLLQAIAKDEVIPLLSPFKKVTANNEPFXXXXXXXXXXXXX 1431
+GSFLSTFGAALQCLCSAPRLLQ+IAKD VIP+LSPF +VT NNEPF
Sbjct: 490 VGSFLSTFGAALQCLCSAPRLLQSIAKDNVIPMLSPFARVTKNNEPFLGLLITTFIAELA 549
Query: 1432 XXMGSMDTIAAVVDFFFLMCYAFVNIICTLHSLLGAPNWRPRFKYYHWFLSLLGAVLCFF 1611
+G++D IA V+DFFFLMCYAFVN+IC LHSL+GAPNWRPRFKYYHW LSL GA LCFF
Sbjct: 550 ILLGAVDAIAEVLDFFFLMCYAFVNLICALHSLMGAPNWRPRFKYYHWSLSLAGAFLCFF 609
Query: 1612 IMFSTHWDYAIVACLLCLVIYKYVEWKGAKKEWGDGIRGLALTTAQYSLMKIEDKEPHPK 1791
IMF++ W YA++AC L IYKYVEWKGAK+EWGDG+RGLALTTAQYSLMK+EDK+PHPK
Sbjct: 610 IMFASCWYYALIACALTGTIYKYVEWKGAKQEWGDGLRGLALTTAQYSLMKVEDKDPHPK 669
Query: 1792 NWRPQLLLLLSMQWSKEIIDVRYLNLLNLASQLKAGKGLTVVTAFLQGDPT---SPDDKK 1962
NWRPQLL+L+ ++SKE+ID+R LNLLNLA QLKAGKGL + AF++ T +++K
Sbjct: 670 NWRPQLLILVDGKYSKEMIDLRSLNLLNLAGQLKAGKGLAITVAFVRCPATRGMHAENRK 729
Query: 1963 KGEQVKARMDFDMNQVRLRGFAKTLVHSEDQVRGSMSTLVQSVGLGGLKPNTMLISWP-V 2139
K E++K R+ DM Q RLRGF K L+++E Q+ G++S L QS+G+GGL+PNT+ +++P +
Sbjct: 730 KAEEIKERVQQDMTQARLRGFGKALLYTETQIEGAVSALYQSIGIGGLRPNTVFLNFPRM 789
Query: 2140 HEREEDMTEYNTFIEKVHAASINDMAIVVAKGIIDFPSAVFRMSGMIDVYWIVHDGGLCL 2319
E ++ TE F E++ + ND +VV KGI FP R+ G +D++ IV DGG+ +
Sbjct: 790 GENQDQHTEQMIFAEQLCCGAQNDNCMVVDKGITAFPRPNDRLRGYLDIWGIVQDGGILM 849
Query: 2320 LMGYLLKQHKVWRGCKLRVIGIAQESDNNVKMQEDLQKYVYQLRIDAKIMIVELADPE-I 2496
L+ YLL+QHKVW+GCK+RV I+Q + NV+++ Q+++Y LRIDA + IV + DP+ +
Sbjct: 850 LIAYLLQQHKVWKGCKMRVYVISQTEEQNVEIKHAFQRHIYMLRIDANVFIVNMIDPDSV 909
Query: 2497 SKNAFERTLLMEE--RTMMMRDLQKVSGGGMSLS--LPPANAPRAPSPLVTSERRANSKX 2664
+A ++TL ME+ RT++ ++L +S GGM L + P T N+
Sbjct: 910 DDDAVQKTLNMEQRTRTLLKKNLSNLSNGGMLNGGFLSDDSGRLTPQ---TRNSANNTLT 966
Query: 2665 XXXXXXXXXXXXXXXXXXXXXXXQANQETKTKKER--MKALDRSKVSKMHTAVRLNELLL 2838
NQ+T ++ +K +D KV KM+ AVRLN+++L
Sbjct: 967 VPGQQQIRQSIIETSFIQKTFEGMDNQDTLNSSDQISLKDIDDVKVQKMNAAVRLNQVIL 1026
Query: 2839 QHSANSQLILLNLPKPPVHKDQQALDDYVHYLEVMTDKLNRVIFVRGTGKEVITESS 3009
++S SQL+LL+LPKPP Q +++Y+ Y+E +T+ L R++ + G+GKEVIT S
Sbjct: 1027 EYSTESQLVLLSLPKPP-KPIQSLVENYLAYVEALTEGLPRIMLIGGSGKEVITADS 1082
>gi|39596034|emb|CAE67537.1| Hypothetical protein CBG13060
[Caenorhabditis briggsae]
Length = 1069
Score = 997 bits (2578), Expect = 0.0
Identities = 513/1017 (50%), Positives = 691/1017 (67%), Gaps = 18/1017 (1%)
Frame = +1
Query: 13 SSYLKAHITPGPLERAQSSSHGGHGAKADLGVLLGVYLPTIQHILGVTMFIRLFWLVGIA 192
+S++ + TPGP ERA S KA+LGV+LGVYLPTIQHILGVTMFIRLFW+VG+A
Sbjct: 67 ASFISGYTTPGPKERATSEH-----VKANLGVMLGVYLPTIQHILGVTMFIRLFWVVGMA 121
Query: 193 GLGQXXXXXXXXXXXXXXXXISISAVATNGVVESGGAYFMISRNLGPEFGSAVGILFYLA 372
G+ IS+SAVATNGVVESGGAYF+ISRNLG EFGSAVGILFYLA
Sbjct: 122 GVAWTMALLAICCLSTLLTSISLSAVATNGVVESGGAYFIISRNLGAEFGSAVGILFYLA 181
Query: 373 NTVATSMYLVGGVEILLLYIFPGLTFGGVEGQHDTSMFGTMTNSLRFYSTILLLIEFAIV 552
NTVA SMY+VGGVE++L+Y++P + GG + HDT MFG++ N+LR Y T+ LLI+ IV
Sbjct: 182 NTVAASMYIVGGVEVILMYLWPEMAIGGADALHDTEMFGSLYNNLRLYGTVFLLIQALIV 241
Query: 553 AMGVKFVQMLAPVSLVCVILSILACYAGGVTKTIYPDSGQYVCMYNDRLLQSSAVL---- 720
AMGVKFVQ+LAPVSL+CV+L+I+AC+ GG+ K I + G VC ++ LLQSS +
Sbjct: 242 AMGVKFVQLLAPVSLMCVVLAIMACFGGGIEKQITME-GMKVCAIDNHLLQSSIITHPLH 300
Query: 721 -NESIPLDEICNYCNI--NNTFLADRVCGGRCNSTTIPHVSPF---------RCINGFPG 864
N++ +E ++CN+ + +L C N F C FPG
Sbjct: 301 KNQTSWSNETLDFCNLCDKSLYLESVFCANVNNDEASAEDDVFCTHYTSKKMTCQMAFPG 360
Query: 865 FQGGQTLLENLGPNYLEKGEAAHGTQADTKSDVYQDVRTSFFVLLAIYFPAVTGIFTGAN 1044
F +TL +N+ P Y+EK E G + ++V QD ++FF+L+AIYFPAVTGIFTG N
Sbjct: 361 FNM-KTLNDNMWPEYMEKTEVVPGVRGKETAEVVQDESSTFFMLMAIYFPAVTGIFTGTN 419
Query: 1045 MSGDLKNPQASIPAGTIAANLTTSFVYFSLAFIFGGAIDNAVLRDKNGQSVGGQMVVALL 1224
MSGDL++PQ SIP GTIAA LTTS +Y++LA +FGG+I+ +VLRDK G+S+G MVVA L
Sbjct: 420 MSGDLRDPQRSIPVGTIAATLTTSAIYYALAILFGGSINRSVLRDKFGRSIGNTMVVAAL 479
Query: 1225 SWPSPWVLLIGSFLSTFGAALQCLCSAPRLLQAIAKDEVIPLLSPFKKVTANNEPFXXXX 1404
SWP P V+ +G+FLSTFGAALQCLCSAPRLLQ+IAKD+VIP+L+PF +VT NNEPF
Sbjct: 480 SWPHPAVVTVGAFLSTFGAALQCLCSAPRLLQSIAKDDVIPILAPFARVTKNNEPFLGLV 539
Query: 1405 XXXXXXXXXXXMGSMDTIAAVVDFFFLMCYAFVNIICTLHSLLGAPNWRPRFKYYHWFLS 1584
+G++D IA V+DFFFLMCYAFVN+I LHS+L +PNWRPRFKY+HW LS
Sbjct: 540 LTVIIAECGILLGAVDKIAEVLDFFFLMCYAFVNLIAVLHSILKSPNWRPRFKYFHWSLS 599
Query: 1585 LLGAVLCFFIMFSTHWDYAIVACLLCLVIYKYVEWKGAKKEWGDGIRGLALTTAQYSLMK 1764
LLGA LCFFIMF++ A +AC VIYKYVEWKGAKKEWGDG+RGLAL+TAQYSL+K
Sbjct: 600 LLGAALCFFIMFASSVPLACIACTATAVIYKYVEWKGAKKEWGDGMRGLALSTAQYSLLK 659
Query: 1765 IEDKEPHPKNWRPQLLLLLSMQWSKEIIDVRYLNLLNLASQLKAGKGLTVVTAFLQGDPT 1944
+EDK+PHPKNWRPQ+L+LL+ QWSKE+ID R +++LNL +QLKAG+GL + AFL+G
Sbjct: 660 VEDKDPHPKNWRPQVLILLTSQWSKEMIDRRAVSMLNLGAQLKAGRGLAIACAFLKGTVD 719
Query: 1945 SPDDKKKGEQVKARMDFDMNQVRLRGFAKTLVHSEDQVRGSMSTLVQSVGLGGLKPNTML 2124
S DK + VK + DM VRLRGFAKT+ ++ Q+ G++S L QS+G+GGL+PNT+L
Sbjct: 720 SQKDKNRARDVKTTLVKDMTSVRLRGFAKTMFYNNHQINGTISGLYQSIGIGGLRPNTIL 779
Query: 2125 ISWPVHEREEDMTEYNTFIEKVHAASINDMAIVVAKGIIDFPSAVFRMSGMIDVYWIVHD 2304
++WP +++ E F E++ + ND ++V KGI DFP R++G ID++WIV D
Sbjct: 780 VNWP---NDKNADELVLFAEEIIHGAANDNCLIVTKGITDFPEYSERLTGFIDIWWIVQD 836
Query: 2305 GGLCLLMGYLLKQHKVWRGCKLRVIGIA-QESDNNVKMQEDLQKYVYQLRIDAKIMIVEL 2481
GG+ +L+ YLL+QHKVW+GC LR+ ++ Q+S + M+ LQKY+Y LRIDA++ IV+L
Sbjct: 837 GGILMLIAYLLRQHKVWKGCTLRIFAVSEQDSTKSEDMKAGLQKYIYMLRIDAELFIVDL 896
Query: 2482 ADPEISKNAFERTLLMEERTMMMRDLQKVSGGGMSLSLPPANAPRAPSPLVTSERRANSK 2661
D E+S E+ +E + ++++ G ++ N P + S+ +
Sbjct: 897 LDMEVSDEVVEKAAEVERKQKEREEMRRSKSGYLNDGYMEDNGKHRPIQMRHSD--STRS 954
Query: 2662 XXXXXXXXXXXXXXXXXXXXXXXXQANQETKTKKERMKALDRSKVSKMHTAVRLNELLLQ 2841
+ T E M+ + + KM+T+VRLN ++ +
Sbjct: 955 FTPQPHTSINLDESAETSFTESLFDDFYRSGTPNEDMEGAMKLNIHKMNTSVRLNRVIRE 1014
Query: 2842 HSANSQLILLNLPKPPVHKDQQALDD-YVHYLEVMTDKLNRVIFVRGTGKEVITESS 3009
+S +SQLILLNLP PP +++ A ++ Y+ YL+V+T+ L RV+F+ G+G+EVIT S
Sbjct: 1015 NSPDSQLILLNLPSPP--RNRLAFNNSYMTYLDVLTEDLPRVLFIGGSGREVITIDS 1069
>gi|17534831|ref|NP_495555.1| Na-K-Cl cotransporter (2H716)
[Caenorhabditis elegans]
gi|1353151|sp|Q09573|YRD3_CAEEL Hypothetical 112.3 kDa protein
K02A2.3 in chromosome II
gi|25395585|pir||G88208 protein K02A2.3 [imported] - Caenorhabditis
elegans
gi|726386|gb|AAC46706.1| Hypothetical protein K02A2.3 [Caenorhabditis
elegans]
Length = 1020
Score = 923 bits (2386), Expect = 0.0
Identities = 493/1017 (48%), Positives = 662/1017 (64%), Gaps = 18/1017 (1%)
Frame = +1
Query: 13 SSYLKAHITPGPLERAQSSSHGGHGAKADLGVLLGVYLPTIQHILGVTMFIRLFWLVGIA 192
+S++ + TPGP ERA S KA+LGV+LGVYLPTIQHILGVTMFIRLFW+VG++
Sbjct: 46 ASFISGYTTPGPKERATSEH-----VKANLGVMLGVYLPTIQHILGVTMFIRLFWVVGMS 100
Query: 193 GLGQXXXXXXXXXXXXXXXXISISAVATNGVVESGGAYFMISRNLGPEFGSAVGILFYLA 372
G+ IS+SAVATNGVVESGGAYF+ISRNLG EFGSAVGILFYLA
Sbjct: 101 GVAWTMALLAICCLSTLLTSISLSAVATNGVVESGGAYFIISRNLGAEFGSAVGILFYLA 160
Query: 373 NTVATSMYLVGGVEILLLYIFPGLTFGGVEGQHDTSMFGTMTNSLRFYSTILLLIEFAIV 552
NTVA SMY+VGGVE++L+Y++P + GG + HDT MFG++ N+LR Y T+ LLI+ IV
Sbjct: 161 NTVAASMYIVGGVEVILMYLWPEMAIGGADALHDTEMFGSLYNNLRLYGTVFLLIQALIV 220
Query: 553 AMGVKFVQMLAPVSLVCVILSILACYAGGVTKTIYPDSGQYVCMYNDRLLQSSAVL---- 720
AMGVKFVQ+LAPVSL+CVIL+I AC GG+ K I + G VC ++ LLQSS V
Sbjct: 221 AMGVKFVQLLAPVSLMCVILAIAACIGGGIEKQITME-GMKVCAIDNHLLQSSIVTHPIH 279
Query: 721 -NESIPLDEICNYCNI--NNTFLADRVCGGRCNSTTIPHVSPF---------RCINGFPG 864
N++ +E ++CN+ + +L C N F C FPG
Sbjct: 280 KNQTSWFNETVDFCNLCDKSLYLESVFCANVNNDEASAEDDVFCTHYTSKKMTCQLAFPG 339
Query: 865 FQGGQTLLENLGPNYLEKGEAAHGTQADTKSDVYQDVRTSFFVLLAIYFPAVTGIFTGAN 1044
F +TL +N+ P Y+EK E G + ++V QD ++FF+L+AIYFPAVTGIFTG N
Sbjct: 340 F-NMKTLNDNMWPEYMEKSEVVPGVRGKETAEVVQDESSTFFMLMAIYFPAVTGIFTGTN 398
Query: 1045 MSGDLKNPQASIPAGTIAANLTTSFVYFSLAFIFGGAIDNAVLRDKNGQSVGGQMVVALL 1224
MSGDL++PQ SIP GTIAA LTTS +Y+ LA +FGG+I +VLRDK G+S+G MVVA L
Sbjct: 399 MSGDLRDPQRSIPVGTIAATLTTSAIYYILAILFGGSITRSVLRDKFGRSIGNTMVVAAL 458
Query: 1225 SWPSPWVLLIGSFLSTFGAALQCLCSAPRLLQAIAKDEVIPLLSPFKKVTANNEPFXXXX 1404
SWP P V+ +G+FLSTFGAALQCLCSAPRLLQ+IAKD+VIP+L+PF +VT NNEPF
Sbjct: 459 SWPHPAVVTVGAFLSTFGAALQCLCSAPRLLQSIAKDDVIPILAPFARVTKNNEPFLGLV 518
Query: 1405 XXXXXXXXXXXMGSMDTIAAVVDFFFLMCYAFVNIICTLHSLLGAPNWRPRFKYYHWFLS 1584
+G++D IA V+DFFFLM LS
Sbjct: 519 LTVIIAECGILLGAVDKIAEVLDFFFLMT-----------------------------LS 549
Query: 1585 LLGAVLCFFIMFSTHWDYAIVACLLCLVIYKYVEWKGAKKEWGDGIRGLALTTAQYSLMK 1764
LLGA LCFFIMF++ A +AC VIYKYVEWKGAKKEWGDG+RGLALTTAQYSL+K
Sbjct: 550 LLGAALCFFIMFASSVPLACIACTATAVIYKYVEWKGAKKEWGDGMRGLALTTAQYSLLK 609
Query: 1765 IEDKEPHPKNWRPQLLLLLSMQWSKEIIDVRYLNLLNLASQLKAGKGLTVVTAFLQGDPT 1944
+EDK+PHPKNWRPQ+L+LL+ QWSKE+ID R +++LNL +QLKAG+GL + AFL+G
Sbjct: 610 VEDKDPHPKNWRPQVLILLTSQWSKEMIDRRAVSMLNLGAQLKAGRGLAIACAFLKGSVD 669
Query: 1945 SPDDKKKGEQVKARMDFDMNQVRLRGFAKTLVHSEDQVRGSMSTLVQSVGLGGLKPNTML 2124
S DK + VK + DM+ VRLRGFAKT+ ++ Q+ G++S L QS+G+GGL+PNT+L
Sbjct: 670 SQKDKNRARDVKTTLVKDMSSVRLRGFAKTMFYNNHQINGTISGLYQSIGIGGLRPNTIL 729
Query: 2125 ISWPVHEREEDMTEYNTFIEKVHAASINDMAIVVAKGIIDFPSAVFRMSGMIDVYWIVHD 2304
++WP E++ E F E++ + ND ++V KGI DFP R++G ID++WIV D
Sbjct: 730 LNWP---NEKNPDELVLFAEEIIHGAANDNCLIVTKGITDFPEYSERLTGFIDIWWIVQD 786
Query: 2305 GGLCLLMGYLLKQHKVWRGCKLRVIGIA-QESDNNVKMQEDLQKYVYQLRIDAKIMIVEL 2481
GG+ +L+ YLL+QHKVW+GC LR+ ++ Q+S + M+ LQKY+Y LRIDA++ IV+L
Sbjct: 787 GGILMLIAYLLRQHKVWKGCTLRIFAVSEQDSTKSEDMKAGLQKYIYMLRIDAELFIVDL 846
Query: 2482 ADPEISKNAFERTLLMEERTMMMRDLQKVSGGGMSLSLPPANAPRAPSPLVTSERRANSK 2661
D E+S E+ +E + ++++ G ++ N + ++ A S
Sbjct: 847 LDMEVSDEVVEKAAEVERKQKEREEMRRSKSGYLNDGFMEDNG-KPRQVMMRHSDSARSF 905
Query: 2662 XXXXXXXXXXXXXXXXXXXXXXXXQANQETKTKKERMKALDRSKVSKMHTAVRLNELLLQ 2841
+ T E ++ + + KM+T+VRLN ++ +
Sbjct: 906 SPQPGAHTSINLDETETSFTESLFDDFYRSGTPNEDLEGAMKLNIHKMNTSVRLNRVIRE 965
Query: 2842 HSANSQLILLNLPKPPVHKDQQALDD-YVHYLEVMTDKLNRVIFVRGTGKEVITESS 3009
+S +SQLILLNLP PP +++ A ++ Y+ YL+V+T+ L RV+F+ G+G+EVIT S
Sbjct: 966 NSPDSQLILLNLPSPP--RNRLAFNNSYMTYLDVLTEDLPRVLFIGGSGREVITIDS 1020
>gi|22026947|ref|NP_571976.2| CG5594-PC [Drosophila melanogaster]
gi|21626680|gb|AAF47099.2| CG5594-PC [Drosophila melanogaster]
Length = 1059
Score = 763 bits (1971), Expect = 0.0
Identities = 408/991 (41%), Positives = 602/991 (60%), Gaps = 22/991 (2%)
Frame = +1
Query: 94 ADLGVLLGVYLPTIQHILGVTMFIRLFWLVGIAGLGQXXXXXXXXXXXXXXXXISISAVA 273
A +G L+GV+LP IQ+I GV +FIRL W+VG AG IS+SA+A
Sbjct: 92 ARMGTLIGVFLPCIQNIFGVILFIRLTWVVGTAGAVCGFLIVLTCCCVTMLTAISMSAIA 151
Query: 274 TNGVVESGGAYFMISRNLGPEFGSAVGILFYLANTVATSMYLVGGVEILLLYIFPGLTFG 453
TNGVV +GG+YFMISR+LGPEFG AVG+LFY T+A +MY+VG VEI+L Y+ P +
Sbjct: 152 TNGVVPAGGSYFMISRSLGPEFGGAVGMLFYTGTTLAAAMYIVGAVEIVLTYMAPWASIF 211
Query: 454 GVEGQHDTSMFGTMTNSLRFYSTILLLIEFAIVAMGVKFVQMLAPVSLVCVILSILACYA 633
G + +M+ N+ R Y T+LL+ IV +GVKFV A V+L CVILSI+A Y
Sbjct: 212 GDFTKDADAMY----NNFRVYGTLLLIFMGLIVFLGVKFVNKFATVALACVILSIIAVYV 267
Query: 634 GGVTKTIYPDSGQYVCMYNDRLLQSSAVLNESIPLDEICNYCNINNTFLADRVC-GGRCN 810
G + I+ + Y+C+ RLL+ IPL+ C ++FL D C G+C
Sbjct: 268 G-IFDNIHGNEKLYMCVLGKRLLKD-------IPLEN----CTKEDSFLRDIYCPDGKCE 315
Query: 811 STTIPHVSPFRCINGFPGFQGGQTLLENLGPNYLEKGEAA---------HGTQADTKSDV 963
+ + + G G G +N+ P++LEKG+ T ++ + +
Sbjct: 316 EYYL--ANNVTKVKGIKGLASG-VFYDNIFPSFLEKGQFISYGKSAIDIENTSGESYNQI 372
Query: 964 YQDVRTSFFVLLAIYFPAVTGIFTGANMSGDLKNPQASIPAGTIAANLTTSFVYFSLAFI 1143
D+ TSF +L+ I+FP+VTGI G+N SGDL + Q SIP GTI A LTTS VY S
Sbjct: 373 MADITTSFTLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTICAILTTSTVYLSSVMF 432
Query: 1144 FGGAIDNAVLRDKNGQSVGGQMVVALLSWPSPWVLLIGSFLSTFGAALQCLCSAPRLLQA 1323
F G +DN +LRDK GQS+GG++VVA ++WP+ WV+LIGSFLST GA LQ L APRLLQA
Sbjct: 433 FAGTVDNLLLRDKFGQSIGGKLVVANIAWPNQWVILIGSFLSTLGAGLQSLTGAPRLLQA 492
Query: 1324 IAKDEVIPLLSPFKKVTANNEPFXXXXXXXXXXXXXXXMGSMDTIAAVVDFFFLMCYAFV 1503
IA+DE+IP L+PF K + EP +G++D +A ++ FFLMCY FV
Sbjct: 493 IARDEIIPFLAPFAKSSKRGEPTRALLLTIVICQCGILLGNVDLLAPLLSMFFLMCYGFV 552
Query: 1504 NIICTLHSLLGAPNWRPRFKYYHWFLSLLGAVLCFFIMFSTHWDYAIVACLLCLVIYKYV 1683
N+ C + +LL PNWRPRFK+YHW LSL+G LC +M T W +A++A + ++IYKY+
Sbjct: 553 NLACAVQTLLRTPNWRPRFKFYHWSLSLIGLTLCISVMIMTSWYFALIAMGMAIIIYKYI 612
Query: 1684 EWKGAKKEWGDGIRGLALTTAQYSLMKIEDKEPHPKNWRPQLLLLLSMQWSKEIIDVRYL 1863
E++GA+KEWGDGIRG+ALT A+YSL+++E+ PH KNWRPQ+L+L + + + +Y
Sbjct: 613 EYRGAEKEWGDGIRGMALTAARYSLLRLEEGPPHTKNWRPQILVLSKL---NDNLLPKYR 669
Query: 1864 NLLNLASQLKAGKGLTVVTAFLQGDPTSPDDKKKGEQVKARMDFDMNQVRLRGFAKTLVH 2043
+ + A+QLKAGKGLT+ + ++GD T + K KA + M +++GF LV
Sbjct: 670 KIFSFATQLKAGKGLTICVSVIKGDHTKITN--KAVDAKATLRKYMTDEKVKGFCDVLV- 726
Query: 2044 SEDQVRGSMSTLVQSVGLGGLKPNTMLISWPVHEREEDMTEYNTFIEKVHAASINDMAIV 2223
Q+ +S+++Q++GLGG+KPNT++I WP R+E + TFI+ V + MA++
Sbjct: 727 -AQQIGEGLSSVIQTIGLGGMKPNTVIIGWPYSWRQEGRNSWKTFIQTVRTVAACHMALM 785
Query: 2224 VAKGIIDFPSAVFRMSGMIDVYWIVHDGGLCLLMGYLLKQHKVWRGCKLRVIGIAQESDN 2403
V KGI +P + ++ G ID++WIVHDGGL +L+ +LLKQH+ WR CKLR+ +AQ DN
Sbjct: 786 VPKGINFYPESNHKIGGNIDIWWIVHDGGLLMLLPFLLKQHRTWRNCKLRIFTVAQIEDN 845
Query: 2404 NVKMQEDLQKYVYQLRIDAKIMIVELADPEISKNAFERTLLMEERTMMMR--DLQKVSGG 2577
+++M++DL+ ++Y LRI+A + +VE+ + +IS +ERTL+ME+R M+R L K
Sbjct: 846 SIQMKKDLKTFLYHLRIEADVEVVEMNNSDISAYTYERTLMMEQRNQMLRALGLNKKENS 905
Query: 2578 GMSLSL--------PPANAPRAPSPLVTSERRANSKXXXXXXXXXXXXXXXXXXXXXXXX 2733
+ ++ A+ R P + + +S+
Sbjct: 906 KVVQTIVDHHYDATKTASKVRFADPTIEETQHHDSQNDEKRNSIDLDGPENADTPETTSN 965
Query: 2734 QANQETKTKKERMKAL--DRSKVSKMHTAVRLNELLLQHSANSQLILLNLPKPPVHKDQQ 2907
+ K + ++ D V +MHTA++LNE++++ S ++QL+++NLP PP +
Sbjct: 966 KDESTEKADGDFKSSVKPDEFNVRRMHTAIKLNEVIVEKSQDAQLVIMNLPGPPREVRAE 1025
Query: 2908 ALDDYVHYLEVMTDKLNRVIFVRGTGKEVIT 3000
+Y+ +LEV+T+ L +V+ VRG G+EVIT
Sbjct: 1026 RERNYMEFLEVLTEGLEKVLMVRGGGREVIT 1056
>gi|24762437|ref|NP_726377.1| CG5594-PD [Drosophila melanogaster]
gi|21626678|gb|AAM68276.1| CG5594-PD [Drosophila melanogaster]
gi|46409210|gb|AAS93762.1| LD02554p [Drosophila melanogaster]
Length = 1074
Score = 763 bits (1971), Expect = 0.0
Identities = 408/991 (41%), Positives = 602/991 (60%), Gaps = 22/991 (2%)
Frame = +1
Query: 94 ADLGVLLGVYLPTIQHILGVTMFIRLFWLVGIAGLGQXXXXXXXXXXXXXXXXISISAVA 273
A +G L+GV+LP IQ+I GV +FIRL W+VG AG IS+SA+A
Sbjct: 107 ARMGTLIGVFLPCIQNIFGVILFIRLTWVVGTAGAVCGFLIVLTCCCVTMLTAISMSAIA 166
Query: 274 TNGVVESGGAYFMISRNLGPEFGSAVGILFYLANTVATSMYLVGGVEILLLYIFPGLTFG 453
TNGVV +GG+YFMISR+LGPEFG AVG+LFY T+A +MY+VG VEI+L Y+ P +
Sbjct: 167 TNGVVPAGGSYFMISRSLGPEFGGAVGMLFYTGTTLAAAMYIVGAVEIVLTYMAPWASIF 226
Query: 454 GVEGQHDTSMFGTMTNSLRFYSTILLLIEFAIVAMGVKFVQMLAPVSLVCVILSILACYA 633
G + +M+ N+ R Y T+LL+ IV +GVKFV A V+L CVILSI+A Y
Sbjct: 227 GDFTKDADAMY----NNFRVYGTLLLIFMGLIVFLGVKFVNKFATVALACVILSIIAVYV 282
Query: 634 GGVTKTIYPDSGQYVCMYNDRLLQSSAVLNESIPLDEICNYCNINNTFLADRVC-GGRCN 810
G + I+ + Y+C+ RLL+ IPL+ C ++FL D C G+C
Sbjct: 283 G-IFDNIHGNEKLYMCVLGKRLLKD-------IPLEN----CTKEDSFLRDIYCPDGKCE 330
Query: 811 STTIPHVSPFRCINGFPGFQGGQTLLENLGPNYLEKGEAA---------HGTQADTKSDV 963
+ + + G G G +N+ P++LEKG+ T ++ + +
Sbjct: 331 EYYL--ANNVTKVKGIKGLASG-VFYDNIFPSFLEKGQFISYGKSAIDIENTSGESYNQI 387
Query: 964 YQDVRTSFFVLLAIYFPAVTGIFTGANMSGDLKNPQASIPAGTIAANLTTSFVYFSLAFI 1143
D+ TSF +L+ I+FP+VTGI G+N SGDL + Q SIP GTI A LTTS VY S
Sbjct: 388 MADITTSFTLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTICAILTTSTVYLSSVMF 447
Query: 1144 FGGAIDNAVLRDKNGQSVGGQMVVALLSWPSPWVLLIGSFLSTFGAALQCLCSAPRLLQA 1323
F G +DN +LRDK GQS+GG++VVA ++WP+ WV+LIGSFLST GA LQ L APRLLQA
Sbjct: 448 FAGTVDNLLLRDKFGQSIGGKLVVANIAWPNQWVILIGSFLSTLGAGLQSLTGAPRLLQA 507
Query: 1324 IAKDEVIPLLSPFKKVTANNEPFXXXXXXXXXXXXXXXMGSMDTIAAVVDFFFLMCYAFV 1503
IA+DE+IP L+PF K + EP +G++D +A ++ FFLMCY FV
Sbjct: 508 IARDEIIPFLAPFAKSSKRGEPTRALLLTIVICQCGILLGNVDLLAPLLSMFFLMCYGFV 567
Query: 1504 NIICTLHSLLGAPNWRPRFKYYHWFLSLLGAVLCFFIMFSTHWDYAIVACLLCLVIYKYV 1683
N+ C + +LL PNWRPRFK+YHW LSL+G LC +M T W +A++A + ++IYKY+
Sbjct: 568 NLACAVQTLLRTPNWRPRFKFYHWSLSLIGLTLCISVMIMTSWYFALIAMGMAIIIYKYI 627
Query: 1684 EWKGAKKEWGDGIRGLALTTAQYSLMKIEDKEPHPKNWRPQLLLLLSMQWSKEIIDVRYL 1863
E++GA+KEWGDGIRG+ALT A+YSL+++E+ PH KNWRPQ+L+L + + + +Y
Sbjct: 628 EYRGAEKEWGDGIRGMALTAARYSLLRLEEGPPHTKNWRPQILVLSKL---NDNLLPKYR 684
Query: 1864 NLLNLASQLKAGKGLTVVTAFLQGDPTSPDDKKKGEQVKARMDFDMNQVRLRGFAKTLVH 2043
+ + A+QLKAGKGLT+ + ++GD T + K KA + M +++GF LV
Sbjct: 685 KIFSFATQLKAGKGLTICVSVIKGDHTKITN--KAVDAKATLRKYMTDEKVKGFCDVLV- 741
Query: 2044 SEDQVRGSMSTLVQSVGLGGLKPNTMLISWPVHEREEDMTEYNTFIEKVHAASINDMAIV 2223
Q+ +S+++Q++GLGG+KPNT++I WP R+E + TFI+ V + MA++
Sbjct: 742 -AQQIGEGLSSVIQTIGLGGMKPNTVIIGWPYSWRQEGRNSWKTFIQTVRTVAACHMALM 800
Query: 2224 VAKGIIDFPSAVFRMSGMIDVYWIVHDGGLCLLMGYLLKQHKVWRGCKLRVIGIAQESDN 2403
V KGI +P + ++ G ID++WIVHDGGL +L+ +LLKQH+ WR CKLR+ +AQ DN
Sbjct: 801 VPKGINFYPESNHKIGGNIDIWWIVHDGGLLMLLPFLLKQHRTWRNCKLRIFTVAQIEDN 860
Query: 2404 NVKMQEDLQKYVYQLRIDAKIMIVELADPEISKNAFERTLLMEERTMMMR--DLQKVSGG 2577
+++M++DL+ ++Y LRI+A + +VE+ + +IS +ERTL+ME+R M+R L K
Sbjct: 861 SIQMKKDLKTFLYHLRIEADVEVVEMNNSDISAYTYERTLMMEQRNQMLRALGLNKKENS 920
Query: 2578 GMSLSL--------PPANAPRAPSPLVTSERRANSKXXXXXXXXXXXXXXXXXXXXXXXX 2733
+ ++ A+ R P + + +S+
Sbjct: 921 KVVQTIVDHHYDATKTASKVRFADPTIEETQHHDSQNDEKRNSIDLDGPENADTPETTSN 980
Query: 2734 QANQETKTKKERMKAL--DRSKVSKMHTAVRLNELLLQHSANSQLILLNLPKPPVHKDQQ 2907
+ K + ++ D V +MHTA++LNE++++ S ++QL+++NLP PP +
Sbjct: 981 KDESTEKADGDFKSSVKPDEFNVRRMHTAIKLNEVIVEKSQDAQLVIMNLPGPPREVRAE 1040
Query: 2908 ALDDYVHYLEVMTDKLNRVIFVRGTGKEVIT 3000
+Y+ +LEV+T+ L +V+ VRG G+EVIT
Sbjct: 1041 RERNYMEFLEVLTEGLEKVLMVRGGGREVIT 1071
>gi|24762441|ref|NP_726379.1| CG5594-PB [Drosophila melanogaster]
gi|21429886|gb|AAM50621.1| GH09271p [Drosophila melanogaster]
gi|21626681|gb|AAM68277.1| CG5594-PB [Drosophila melanogaster]
Length = 1028
Score = 763 bits (1970), Expect = 0.0
Identities = 407/979 (41%), Positives = 597/979 (60%), Gaps = 10/979 (1%)
Frame = +1
Query: 94 ADLGVLLGVYLPTIQHILGVTMFIRLFWLVGIAGLGQXXXXXXXXXXXXXXXXISISAVA 273
A +G L+GV+LP IQ+I GV +FIRL W+VG AG IS+SA+A
Sbjct: 92 ARMGTLIGVFLPCIQNIFGVILFIRLTWVVGTAGAVCGFLIVLTCCCVTMLTAISMSAIA 151
Query: 274 TNGVVESGGAYFMISRNLGPEFGSAVGILFYLANTVATSMYLVGGVEILLLYIFPGLTFG 453
TNGVV +GG+YFMISR+LGPEFG AVG+LFY T+A +MY+VG VEI+L Y+ P +
Sbjct: 152 TNGVVPAGGSYFMISRSLGPEFGGAVGMLFYTGTTLAAAMYIVGAVEIVLTYMAPWASIF 211
Query: 454 GVEGQHDTSMFGTMTNSLRFYSTILLLIEFAIVAMGVKFVQMLAPVSLVCVILSILACYA 633
G + +M+ N+ R Y T+LL+ IV +GVKFV A V+L CVILSI+A Y
Sbjct: 212 GDFTKDADAMY----NNFRVYGTLLLIFMGLIVFLGVKFVNKFATVALACVILSIIAVYV 267
Query: 634 GGVTKTIYPDSGQYVCMYNDRLLQSSAVLNESIPLDEICNYCNINNTFLADRVC-GGRCN 810
G + I+ + Y+C+ RLL+ IPL+ C ++FL D C G+C
Sbjct: 268 G-IFDNIHGNEKLYMCVLGKRLLKD-------IPLEN----CTKEDSFLRDIYCPDGKCE 315
Query: 811 STTIPHVSPFRCINGFPGFQGGQTLLENLGPNYLEKGEAA---------HGTQADTKSDV 963
+ + + G G G +N+ P++LEKG+ T ++ + +
Sbjct: 316 EYYL--ANNVTKVKGIKGLASG-VFYDNIFPSFLEKGQFISYGKSAIDIENTSGESYNQI 372
Query: 964 YQDVRTSFFVLLAIYFPAVTGIFTGANMSGDLKNPQASIPAGTIAANLTTSFVYFSLAFI 1143
D+ TSF +L+ I+FP+VTGI G+N SGDL + Q SIP GTI A LTTS VY S
Sbjct: 373 MADITTSFTLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTICAILTTSTVYLSSVMF 432
Query: 1144 FGGAIDNAVLRDKNGQSVGGQMVVALLSWPSPWVLLIGSFLSTFGAALQCLCSAPRLLQA 1323
F G +DN +LRDK GQS+GG++VVA ++WP+ WV+LIGSFLST GA LQ L APRLLQA
Sbjct: 433 FAGTVDNLLLRDKFGQSIGGKLVVANIAWPNQWVILIGSFLSTLGAGLQSLTGAPRLLQA 492
Query: 1324 IAKDEVIPLLSPFKKVTANNEPFXXXXXXXXXXXXXXXMGSMDTIAAVVDFFFLMCYAFV 1503
IA+DE+IP L+PF K + EP +G++D +A ++ FFLMCY FV
Sbjct: 493 IARDEIIPFLAPFAKSSKRGEPTRALLLTIVICQCGILLGNVDLLAPLLSMFFLMCYGFV 552
Query: 1504 NIICTLHSLLGAPNWRPRFKYYHWFLSLLGAVLCFFIMFSTHWDYAIVACLLCLVIYKYV 1683
N+ C + +LL PNWRPRFK+YHW LSL+G LC +M T W +A++A + ++IYKY+
Sbjct: 553 NLACAVQTLLRTPNWRPRFKFYHWSLSLIGLTLCISVMIMTSWYFALIAMGMAIIIYKYI 612
Query: 1684 EWKGAKKEWGDGIRGLALTTAQYSLMKIEDKEPHPKNWRPQLLLLLSMQWSKEIIDVRYL 1863
E++GA+KEWGDGIRG+ALT A+YSL+++E+ PH KNWRPQ+L+L + + + +Y
Sbjct: 613 EYRGAEKEWGDGIRGMALTAARYSLLRLEEGPPHTKNWRPQILVLSKL---NDNLLPKYR 669
Query: 1864 NLLNLASQLKAGKGLTVVTAFLQGDPTSPDDKKKGEQVKARMDFDMNQVRLRGFAKTLVH 2043
+ + A+QLKAGKGLT+ + ++GD T + K KA + M +++GF LV
Sbjct: 670 KIFSFATQLKAGKGLTICVSVIKGDHTKITN--KAVDAKATLRKYMTDEKVKGFCDVLV- 726
Query: 2044 SEDQVRGSMSTLVQSVGLGGLKPNTMLISWPVHEREEDMTEYNTFIEKVHAASINDMAIV 2223
Q+ +S+++Q++GLGG+KPNT++I WP R+E + TFI+ V + MA++
Sbjct: 727 -AQQIGEGLSSVIQTIGLGGMKPNTVIIGWPYSWRQEGRNSWKTFIQTVRTVAACHMALM 785
Query: 2224 VAKGIIDFPSAVFRMSGMIDVYWIVHDGGLCLLMGYLLKQHKVWRGCKLRVIGIAQESDN 2403
V KGI +P + ++ G ID++WIVHDGGL +L+ +LLKQH+ WR CKLR+ +AQ DN
Sbjct: 786 VPKGINFYPESNHKIGGNIDIWWIVHDGGLLMLLPFLLKQHRTWRNCKLRIFTVAQIEDN 845
Query: 2404 NVKMQEDLQKYVYQLRIDAKIMIVELADPEISKNAFERTLLMEERTMMMRDLQKVSGGGM 2583
+++M++DL+ ++Y LRI+A + +VE+ + +IS +ERTL+ME+R M+R
Sbjct: 846 SIQMKKDLKTFLYHLRIEADVEVVEMNNSDISAYTYERTLMMEQRNQMLR---------- 895
Query: 2584 SLSLPPANAPRAPSPLVTSERRANSKXXXXXXXXXXXXXXXXXXXXXXXXQANQETKTKK 2763
+L L + S ++ + NS + ++ K
Sbjct: 896 ALGLNKKENSKVDS---QNDEKRNSIDLDGPENADTPETTSNKDESTEKADGDFKSSVKP 952
Query: 2764 ERMKALDRSKVSKMHTAVRLNELLLQHSANSQLILLNLPKPPVHKDQQALDDYVHYLEVM 2943
D V +MHTA++LNE++++ S ++QL+++NLP PP + +Y+ +LEV+
Sbjct: 953 ------DEFNVRRMHTAIKLNEVIVEKSQDAQLVIMNLPGPPREVRAERERNYMEFLEVL 1006
Query: 2944 TDKLNRVIFVRGTGKEVIT 3000
T+ L +V+ VRG G+EVIT
Sbjct: 1007 TEGLEKVLMVRGGGREVIT 1025
>gi|24762439|ref|NP_726378.1| CG5594-PA [Drosophila melanogaster]
gi|21626679|gb|AAF47098.2| CG5594-PA [Drosophila melanogaster]
Length = 1043
Score = 763 bits (1970), Expect = 0.0
Identities = 407/979 (41%), Positives = 597/979 (60%), Gaps = 10/979 (1%)
Frame = +1
Query: 94 ADLGVLLGVYLPTIQHILGVTMFIRLFWLVGIAGLGQXXXXXXXXXXXXXXXXISISAVA 273
A +G L+GV+LP IQ+I GV +FIRL W+VG AG IS+SA+A
Sbjct: 107 ARMGTLIGVFLPCIQNIFGVILFIRLTWVVGTAGAVCGFLIVLTCCCVTMLTAISMSAIA 166
Query: 274 TNGVVESGGAYFMISRNLGPEFGSAVGILFYLANTVATSMYLVGGVEILLLYIFPGLTFG 453
TNGVV +GG+YFMISR+LGPEFG AVG+LFY T+A +MY+VG VEI+L Y+ P +
Sbjct: 167 TNGVVPAGGSYFMISRSLGPEFGGAVGMLFYTGTTLAAAMYIVGAVEIVLTYMAPWASIF 226
Query: 454 GVEGQHDTSMFGTMTNSLRFYSTILLLIEFAIVAMGVKFVQMLAPVSLVCVILSILACYA 633
G + +M+ N+ R Y T+LL+ IV +GVKFV A V+L CVILSI+A Y
Sbjct: 227 GDFTKDADAMY----NNFRVYGTLLLIFMGLIVFLGVKFVNKFATVALACVILSIIAVYV 282
Query: 634 GGVTKTIYPDSGQYVCMYNDRLLQSSAVLNESIPLDEICNYCNINNTFLADRVC-GGRCN 810
G + I+ + Y+C+ RLL+ IPL+ C ++FL D C G+C
Sbjct: 283 G-IFDNIHGNEKLYMCVLGKRLLKD-------IPLEN----CTKEDSFLRDIYCPDGKCE 330
Query: 811 STTIPHVSPFRCINGFPGFQGGQTLLENLGPNYLEKGEAA---------HGTQADTKSDV 963
+ + + G G G +N+ P++LEKG+ T ++ + +
Sbjct: 331 EYYL--ANNVTKVKGIKGLASG-VFYDNIFPSFLEKGQFISYGKSAIDIENTSGESYNQI 387
Query: 964 YQDVRTSFFVLLAIYFPAVTGIFTGANMSGDLKNPQASIPAGTIAANLTTSFVYFSLAFI 1143
D+ TSF +L+ I+FP+VTGI G+N SGDL + Q SIP GTI A LTTS VY S
Sbjct: 388 MADITTSFTLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTICAILTTSTVYLSSVMF 447
Query: 1144 FGGAIDNAVLRDKNGQSVGGQMVVALLSWPSPWVLLIGSFLSTFGAALQCLCSAPRLLQA 1323
F G +DN +LRDK GQS+GG++VVA ++WP+ WV+LIGSFLST GA LQ L APRLLQA
Sbjct: 448 FAGTVDNLLLRDKFGQSIGGKLVVANIAWPNQWVILIGSFLSTLGAGLQSLTGAPRLLQA 507
Query: 1324 IAKDEVIPLLSPFKKVTANNEPFXXXXXXXXXXXXXXXMGSMDTIAAVVDFFFLMCYAFV 1503
IA+DE+IP L+PF K + EP +G++D +A ++ FFLMCY FV
Sbjct: 508 IARDEIIPFLAPFAKSSKRGEPTRALLLTIVICQCGILLGNVDLLAPLLSMFFLMCYGFV 567
Query: 1504 NIICTLHSLLGAPNWRPRFKYYHWFLSLLGAVLCFFIMFSTHWDYAIVACLLCLVIYKYV 1683
N+ C + +LL PNWRPRFK+YHW LSL+G LC +M T W +A++A + ++IYKY+
Sbjct: 568 NLACAVQTLLRTPNWRPRFKFYHWSLSLIGLTLCISVMIMTSWYFALIAMGMAIIIYKYI 627
Query: 1684 EWKGAKKEWGDGIRGLALTTAQYSLMKIEDKEPHPKNWRPQLLLLLSMQWSKEIIDVRYL 1863
E++GA+KEWGDGIRG+ALT A+YSL+++E+ PH KNWRPQ+L+L + + + +Y
Sbjct: 628 EYRGAEKEWGDGIRGMALTAARYSLLRLEEGPPHTKNWRPQILVLSKL---NDNLLPKYR 684
Query: 1864 NLLNLASQLKAGKGLTVVTAFLQGDPTSPDDKKKGEQVKARMDFDMNQVRLRGFAKTLVH 2043
+ + A+QLKAGKGLT+ + ++GD T + K KA + M +++GF LV
Sbjct: 685 KIFSFATQLKAGKGLTICVSVIKGDHTKITN--KAVDAKATLRKYMTDEKVKGFCDVLV- 741
Query: 2044 SEDQVRGSMSTLVQSVGLGGLKPNTMLISWPVHEREEDMTEYNTFIEKVHAASINDMAIV 2223
Q+ +S+++Q++GLGG+KPNT++I WP R+E + TFI+ V + MA++
Sbjct: 742 -AQQIGEGLSSVIQTIGLGGMKPNTVIIGWPYSWRQEGRNSWKTFIQTVRTVAACHMALM 800
Query: 2224 VAKGIIDFPSAVFRMSGMIDVYWIVHDGGLCLLMGYLLKQHKVWRGCKLRVIGIAQESDN 2403
V KGI +P + ++ G ID++WIVHDGGL +L+ +LLKQH+ WR CKLR+ +AQ DN
Sbjct: 801 VPKGINFYPESNHKIGGNIDIWWIVHDGGLLMLLPFLLKQHRTWRNCKLRIFTVAQIEDN 860
Query: 2404 NVKMQEDLQKYVYQLRIDAKIMIVELADPEISKNAFERTLLMEERTMMMRDLQKVSGGGM 2583
+++M++DL+ ++Y LRI+A + +VE+ + +IS +ERTL+ME+R M+R
Sbjct: 861 SIQMKKDLKTFLYHLRIEADVEVVEMNNSDISAYTYERTLMMEQRNQMLR---------- 910
Query: 2584 SLSLPPANAPRAPSPLVTSERRANSKXXXXXXXXXXXXXXXXXXXXXXXXQANQETKTKK 2763
+L L + S ++ + NS + ++ K
Sbjct: 911 ALGLNKKENSKVDS---QNDEKRNSIDLDGPENADTPETTSNKDESTEKADGDFKSSVKP 967
Query: 2764 ERMKALDRSKVSKMHTAVRLNELLLQHSANSQLILLNLPKPPVHKDQQALDDYVHYLEVM 2943
D V +MHTA++LNE++++ S ++QL+++NLP PP + +Y+ +LEV+
Sbjct: 968 ------DEFNVRRMHTAIKLNEVIVEKSQDAQLVIMNLPGPPREVRAERERNYMEFLEVL 1021
Query: 2944 TDKLNRVIFVRGTGKEVIT 3000
T+ L +V+ VRG G+EVIT
Sbjct: 1022 TEGLEKVLMVRGGGREVIT 1040
>gi|47522728|ref|NP_999114.1| K-Cl cotransporter [Sus scrofa]
gi|7513455|pir||T14114 K-Cl cotransport protein - pig
gi|2599467|gb|AAB84137.1| K-Cl cotransporter [Sus scrofa]
Length = 1086
Score = 748 bits (1930), Expect = 0.0
Identities = 431/1033 (41%), Positives = 602/1033 (57%), Gaps = 43/1033 (4%)
Frame = +1
Query: 31 HITPGPLERAQSSSHGG---HGAKA-DLGVLLGVYLPTIQHILGVTMFIRLFWLVGIAGL 198
++T G E ++ S G AKA +G L+GVYLP +Q+I GV +F+RL W+VG AG+
Sbjct: 91 NLTQGAKEHEEAESGEGTRRRAAKAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGV 150
Query: 199 GQXXXXXXXXXXXXXXXXISISAVATNGVVESGGAYFMISRNLGPEFGSAVGILFYLANT 378
Q IS+SA+ATNGVV +GG+YFMISR+LGPEFG AVG+ FYL T
Sbjct: 151 LQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTT 210
Query: 379 VATSMYLVGGVEILLLYIFPGLTFGGVEGQHDTSMFGTMTNSLRFYSTILLLIEFAIVAM 558
A +MY++G +EILL YI P G HDTS N++R Y TI L +V +
Sbjct: 211 FAAAMYILGAIEILLTYIAPPAAIFYPTGTHDTS--SATLNNMRVYGTIFLTFMTLVVFV 268
Query: 559 GVKFVQMLAPVSLVCVILSILACYAGGVTKTIYPDSGQYVCMYNDRLLQSSAVLNESIPL 738
GVK+V A + L CVI+SIL+ YAGG+ K+I+ VCM +R L
Sbjct: 269 GVKYVNKFASLFLACVIISILSIYAGGI-KSIFDPPVFPVCMLGNRTLSRDQ-------F 320
Query: 739 DEICNYCNINNTFLADRVCGGRCNST--TIPHVSPFRCING---FPGFQGG--QTLLENL 897
D ++N + R+ C+S T P+ +N PG G L ENL
Sbjct: 321 DVCAKTVMVDNETVTTRLWSLFCHSPNLTADSCDPYFLLNNVTEIPGIPGAAASVLQENL 380
Query: 898 GPNYLEKGEA----------AHGTQADTKSDVYQDVRTSFFVLLAIYFPAVTGIFTGANM 1047
YLEKGE A G + V D+ TSF VL+ I+FP+VTGI G+N
Sbjct: 381 WSAYLEKGEVVEKHGLPSTDALGLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGSNR 440
Query: 1048 SGDLKNPQASIPAGTIAANLTTSFVYFSLAFIFGGAIDNAVLRDKNGQSVGGQMVVALLS 1227
SGDL++ Q SIP GTI A +TTS VYFS +FG I+ VLRDK G V +VV L+
Sbjct: 441 SGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLA 500
Query: 1228 WPSPWVLLIGSFLSTFGAALQCLCSAPRLLQAIAKDEVIPLLSPFKKVTANNEPFXXXXX 1407
WPSPWV++IGSF ST GA LQ L APRLLQAIAKD +IP L F AN EP
Sbjct: 501 WPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKANGEPTWALLL 560
Query: 1408 XXXXXXXXXXMGSMDTIAAVVDFFFLMCYAFVNIICTLHSLLGAPNWRPRFKYYHWFLSL 1587
+ S+D +A ++ FFLMCY FVN+ C + +LL PNWRPRFKYYHW LS
Sbjct: 561 TALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSF 620
Query: 1588 LGAVLCFFIMFSTHWDYAIVACLLCLVIYKYVEWKGAKKEWGDGIRGLALTTAQYSLMKI 1767
LG LC +MF + W YA+VA L+ +IYKY+E++GA+KEWGDGIRGL+L+ A+Y+L+++
Sbjct: 621 LGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRL 680
Query: 1768 EDKEPHPKNWRPQLLLLLSMQWSKEIIDVRYLNLLNLASQLKAGKGLTVVTAFLQGD-PT 1944
E+ PH KNWRPQLL+LL + E + V+Y LL ASQLKAGKGLT+V + +QG
Sbjct: 681 EEGPPHTKNWRPQLLVLLKLD---EDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLE 737
Query: 1945 SPDDKKKGEQVKARMDFDMNQVRLRGFAKTLVHSEDQVRGSMSTLVQSVGLGGLKPNTML 2124
S + + EQ M M +++GF + +V S +VR ++ L+QS GLGG++ N+++
Sbjct: 738 SYGEAQAAEQTIKNM---MEIEKVKGFCQVVVAS--KVREGLAHLIQSCGLGGMRHNSVV 792
Query: 2125 ISWPVHERE-EDMTEYNTFIEKVHAASINDMAIVVAKGIIDFPSAVFR-MSGMIDVYWIV 2298
+ WP R+ ED + TFI+ V + +A++V K I +PS R + G IDV+WIV
Sbjct: 793 LGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIV 852
Query: 2299 HDGGLCLLMGYLLKQHKVWRGCKLRVIGIAQESDNNVKMQEDLQKYVYQLRIDAKIMIVE 2478
HDGG+ +L+ +LL+QHKVWR C++R+ +AQ DN+++M++DL ++Y LR++A++ +VE
Sbjct: 853 HDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAIFLYHLRLEAEVEVVE 912
Query: 2479 LADPEISKNAFERTLLMEERTMMMRDLQKVSGGGMSLSLPPANAPRAPSPLVTSERRANS 2658
+ + +IS +ERTL+ME+R+ M+R ++ ER A
Sbjct: 913 MPNSDISAYTYERTLMMEQRSQMLRQMRLTK--------------------TEREREAQL 952
Query: 2659 KXXXXXXXXXXXXXXXXXXXXXXXXQANQETKTKKERMKA-------------------L 2781
Q T T+ + M+A
Sbjct: 953 VKDRHSALRLESLYSDEEDESVAGTDKIQMTWTRDKYMEAEPWDPSHTPDNFRELVHIKP 1012
Query: 2782 DRSKVSKMHTAVRLNELLLQHSANSQLILLNLPKPPVHKDQQALDDYVHYLEVMTDKLNR 2961
D+S V +MHTAV+LNE+++ S +++L+LLN+P PP K+ + ++Y+ +LEV+T+ L R
Sbjct: 1013 DQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPP--KNSEGDENYMEFLEVLTEGLER 1070
Query: 2962 VIFVRGTGKEVIT 3000
V+ VRG G+EVIT
Sbjct: 1071 VLLVRGGGREVIT 1083
>gi|27151684|sp|Q28677|S124_RABIT Solute carrier family 12 member 4
(Electroneutral potassium-chloride cotransporter 1)
(Erythroid K-Cl cotransporter 1) (rbKCC1)
gi|7513559|pir||T18369 K-Cl cotransport protein - rabbit
gi|1399214|gb|AAC48593.1| K-Cl cotransporter
Length = 1085
Score = 746 bits (1927), Expect = 0.0
Identities = 426/1025 (41%), Positives = 606/1025 (58%), Gaps = 35/1025 (3%)
Frame = +1
Query: 31 HITPGPLERAQSSSHGG---HGAKA-DLGVLLGVYLPTIQHILGVTMFIRLFWLVGIAGL 198
++T G E ++ S G AKA +G L+GVYLP +Q+I GV +F+RL W+VG AG+
Sbjct: 91 NLTQGAKEHEEAESGEGTRRRAAKAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGV 150
Query: 199 GQXXXXXXXXXXXXXXXXISISAVATNGVVESGGAYFMISRNLGPEFGSAVGILFYLANT 378
Q IS+SA+ATNGVV +GG+YFMISR+LGPEFG AVG+ FYL T
Sbjct: 151 LQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTT 210
Query: 379 VATSMYLVGGVEILLLYIFPGLTFGGVEGQHDTSMFGTMTNSLRFYSTILLLIEFAIVAM 558
A +MY++G +EILL YI P G HDTS N++R Y T+ L +V +
Sbjct: 211 FAAAMYILGAIEILLTYIAPPAAIFYPSGTHDTS--NATLNNMRVYGTVFLSFMTLVVFV 268
Query: 559 GVKFVQMLAPVSLVCVILSILACYAGGVTKTIYPDSGQYVCMYNDRLLQSSAVLNESIPL 738
GVK+V A + L CVI+SIL+ YAGG+ K+++ VCM +R L
Sbjct: 269 GVKYVNKFASLFLACVIISILSIYAGGI-KSMFDPPVFPVCMLGNRTLSRDQ-------F 320
Query: 739 DEICNYCNINNTFLADRVCGGRCNST--TIPHVSPFRCIN------GFPGFQGGQTLLEN 894
D ++N +A R+ C+S T P+ +N G PG G L EN
Sbjct: 321 DICAKTTMVDNETVATRLWSFFCHSPNLTTDSCDPYFLLNNVTEIPGIPGAAAG-VLQEN 379
Query: 895 LGPNYLEKGEA----------AHGTQADTKSDVYQDVRTSFFVLLAIYFPAVTGIFTGAN 1044
L YLEKGE A G + + V D+ TSF VL+ I+FP+VTGI G+N
Sbjct: 380 LWSAYLEKGEVVEKRGLPSTDAVGLKENLPLYVVADIATSFTVLVGIFFPSVTGIMAGSN 439
Query: 1045 MSGDLKNPQASIPAGTIAANLTTSFVYFSLAFIFGGAIDNAVLRDKNGQSVGGQMVVALL 1224
SGDL++ Q SIP GTI A +TTS VYFS +FG I+ VLRDK G V +VV L
Sbjct: 440 RSGDLRDAQKSIPVGTILAIVTTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTL 499
Query: 1225 SWPSPWVLLIGSFLSTFGAALQCLCSAPRLLQAIAKDEVIPLLSPFKKVTANNEPFXXXX 1404
+WPSPWV+++GSF ST GA LQ L APRLLQAIAKD +IP L F AN EP
Sbjct: 500 AWPSPWVIVVGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKANGEPTWALL 559
Query: 1405 XXXXXXXXXXXMGSMDTIAAVVDFFFLMCYAFVNIICTLHSLLGAPNWRPRFKYYHWFLS 1584
+ S+D +A ++ FFLMCY FVN+ C + +LL PNWRPRFKYYHW LS
Sbjct: 560 LTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALS 619
Query: 1585 LLGAVLCFFIMFSTHWDYAIVACLLCLVIYKYVEWKGAKKEWGDGIRGLALTTAQYSLMK 1764
LG LC +MF + W YA+VA L+ +IYKY+E++GA+KEWGDGIRGL+L+ A+Y+L++
Sbjct: 620 FLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLR 679
Query: 1765 IEDKEPHPKNWRPQLLLLLSMQWSKEIIDVRYLNLLNLASQLKAGKGLTVVTAFLQGD-P 1941
+E+ PH KNWRPQLL+LL + E + V+Y LL ASQLKAGKGLT+V + +QG
Sbjct: 680 LEEGPPHTKNWRPQLLVLLKLD---EDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFL 736
Query: 1942 TSPDDKKKGEQVKARMDFDMNQVRLRGFAKTLVHSEDQVRGSMSTLVQSVGLGGLKPNTM 2121
S + + EQ M M +++GF + +V S +VR ++ L+QS GLGG++ N++
Sbjct: 737 ESYGEAQAAEQTIKNM---MKIEKVKGFCQVVVAS--KVREGLAHLIQSCGLGGMRHNSV 791
Query: 2122 LISWPVHERE-EDMTEYNTFIEKVHAASINDMAIVVAKGIIDFPSAVFR-MSGMIDVYWI 2295
++ WP R+ ED + TFI+ V + +A++V K I +PS R + G IDV+WI
Sbjct: 792 VLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWI 851
Query: 2296 VHDGGLCLLMGYLLKQHKVWRGCKLRVIGIAQESDNNVKMQEDLQKYVYQLRIDAKIMIV 2475
VHDGG+ +L+ +LL+QHKVWR C++R+ +AQ DN+++M++DL ++Y LR++A++ +V
Sbjct: 852 VHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEVV 911
Query: 2476 ELADPEISKNAFERTLLMEERTMMMRDLQKVSGGGMSLSLPPANAPRAPSPLVTSERRAN 2655
E+ + +IS +ERTL+ME+R+ M+R ++ R + +R +
Sbjct: 912 EMHNSDISAYTYERTLMMEQRSQMLRQMRL------------TKTEREREAQLVKDRHSA 959
Query: 2656 SKXXXXXXXXXXXXXXXXXXXXXXXXQANQETKT-----KKERMKAL-----DRSKVSKM 2805
+ + T+ + + L D+S V +M
Sbjct: 960 LRLESLYSDEEDEAAAGADKIQMTWTRDKYMTEPWDPSHTPDNFRELVHIKPDQSNVRRM 1019
Query: 2806 HTAVRLNELLLQHSANSQLILLNLPKPPVHKDQQALDDYVHYLEVMTDKLNRVIFVRGTG 2985
HTAV+LNE+++ S +++L+LLN+P PP K+ + ++Y+ +LEV+T+ L RV+ VRG G
Sbjct: 1020 HTAVKLNEVIVTRSHDARLVLLNMPGPP--KNSEGDENYMEFLEVLTEGLERVLLVRGGG 1077
Query: 2986 KEVIT 3000
+EVIT
Sbjct: 1078 REVIT 1082
>gi|45219767|gb|AAH66872.1| Solute carrier family 12, member 4 [Mus
musculus]
Length = 1085
Score = 745 bits (1924), Expect = 0.0
Identities = 427/1018 (41%), Positives = 605/1018 (58%), Gaps = 28/1018 (2%)
Frame = +1
Query: 31 HITPGPLERAQSSSHGG---HGAKA-DLGVLLGVYLPTIQHILGVTMFIRLFWLVGIAGL 198
++T G E ++ S G AKA +G L+GVYLP +Q+I GV +F+RL W+VG AG+
Sbjct: 91 NLTQGAKEHEEAESGEGGRRRAAKAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGV 150
Query: 199 GQXXXXXXXXXXXXXXXXISISAVATNGVVESGGAYFMISRNLGPEFGSAVGILFYLANT 378
Q IS+SA+ATNGVV +GG+YFMISR+LGPEFG AVG+ FYL T
Sbjct: 151 LQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTT 210
Query: 379 VATSMYLVGGVEILLLYIFPGLTFGGVEGQHDTSMFGTMTNSLRFYSTILLLIEFAIVAM 558
A +MY++G +EILL YI P G HD S N++R Y TI L + +V +
Sbjct: 211 FAAAMYILGAIEILLTYIAPPAAIFYPSGTHDMS--SATLNNMRVYGTIFLTLMTLVVFV 268
Query: 559 GVKFVQMLAPVSLVCVILSILACYAGGVTKTIYPDSGQYVCMYNDRLLQSSAVLNESIPL 738
GVK+V A + L CVI+SIL+ YAGG+ K+I+ VCM +R L
Sbjct: 269 GVKYVNKFASLFLACVIISILSIYAGGI-KSIFDPPVFPVCMLGNRTLSRDQ-------F 320
Query: 739 DEICNYCNINNTFLADRVCGGRCNST--TIPHVSPFRCIN------GFPGFQGGQTLLEN 894
D ++N +A R+ C+S T P+ +N G PG G L EN
Sbjct: 321 DICAKTVVVDNETVATRLWTFFCHSPNLTADSCDPYFLLNNVTEIPGIPGAAAG-VLQEN 379
Query: 895 LGPNYLEKGEAAH----------GTQADTKSDVYQDVRTSFFVLLAIYFPAVTGIFTGAN 1044
L YLEKGE G + V D+ TSF VL+ I+FP+VTGI G+N
Sbjct: 380 LWSAYLEKGEVVEKHGLPSTDTLGLKESLSLYVVADIATSFTVLVGIFFPSVTGIMAGSN 439
Query: 1045 MSGDLKNPQASIPAGTIAANLTTSFVYFSLAFIFGGAIDNAVLRDKNGQSVGGQMVVALL 1224
SGDL++ Q SIP GTI A +TTS VYFS +FG I+ VLRDK G V +VV L
Sbjct: 440 RSGDLRDAQKSIPVGTILAIVTTSLVYFSSVILFGACIEGVVLRDKYGDGVSRNLVVGTL 499
Query: 1225 SWPSPWVLLIGSFLSTFGAALQCLCSAPRLLQAIAKDEVIPLLSPFKKVTANNEPFXXXX 1404
+WPSPWV+++GSF ST GA LQ L APRLLQAIAKD +IP L F AN EP
Sbjct: 500 AWPSPWVIVVGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKANGEPTWVLL 559
Query: 1405 XXXXXXXXXXXMGSMDTIAAVVDFFFLMCYAFVNIICTLHSLLGAPNWRPRFKYYHWFLS 1584
+ S+D +A ++ FFLMCY FVN+ C + +LL PNWRPRFKYYHW LS
Sbjct: 560 LTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWTLS 619
Query: 1585 LLGAVLCFFIMFSTHWDYAIVACLLCLVIYKYVEWKGAKKEWGDGIRGLALTTAQYSLMK 1764
LG LC +MF + W YA+VA L+ +IYKY+E++GA+KEWGDGIRGL+L+ A+Y+L++
Sbjct: 620 FLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLR 679
Query: 1765 IEDKEPHPKNWRPQLLLLLSMQWSKEIIDVRYLNLLNLASQLKAGKGLTVVTAFLQGD-P 1941
+E+ PH KNWRPQLL+LL + E + V+Y LL ASQLKAGKGLT+V + +QG
Sbjct: 680 LEEGPPHTKNWRPQLLVLLKLD---EDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFL 736
Query: 1942 TSPDDKKKGEQ-VKARMDFDMNQVRLRGFAKTLVHSEDQVRGSMSTLVQSVGLGGLKPNT 2118
S + + EQ +K MD + +++GF + +V S+ VR ++ L+QS GLGG++ N+
Sbjct: 737 ESYGEAQAAEQTIKNMMDIE----KVKGFCQVVVASK--VREGLAHLIQSCGLGGMRHNS 790
Query: 2119 MLISWPVHERE-EDMTEYNTFIEKVHAASINDMAIVVAKGIIDFPSAVFR-MSGMIDVYW 2292
+++ WP R+ ED + TFI+ V + +A++V K I +PS R + G IDV+W
Sbjct: 791 VVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLDGHIDVWW 850
Query: 2293 IVHDGGLCLLMGYLLKQHKVWRGCKLRVIGIAQESDNNVKMQEDLQKYVYQLRIDAKIMI 2472
IVHDGG+ +L+ +LL+QHKVW+ C++R+ +AQ DN+++M++DL ++Y LR++A++ +
Sbjct: 851 IVHDGGMLMLLPFLLRQHKVWKKCRMRIFTVAQMDDNSIQMKKDLAIFLYHLRLEAEVEV 910
Query: 2473 VELADPEISKNAFERTLLMEERTMMMRD--LQKVSGGGMSLSLPPANAPRAPSPLVTSER 2646
VE+ + +IS +ERTL+ME+R+ M+R L K + + ++ L + E
Sbjct: 911 VEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTERDREAQLVKDRHSALRLESLYSDEE 970
Query: 2647 RANSKXXXXXXXXXXXXXXXXXXXXXXXXQANQETKTKKERMKALDRSKVSKMHTAVRLN 2826
+ N + D+S V +MHTAV+LN
Sbjct: 971 EESVAGADKIQMTWTRDKYMAEPWDPSHAPDNFRELVHIKP----DQSNVRRMHTAVKLN 1026
Query: 2827 ELLLQHSANSQLILLNLPKPPVHKDQQALDDYVHYLEVMTDKLNRVIFVRGTGKEVIT 3000
E+++ S +++L+LLN+P PP K+ + ++Y+ +LEV+T+ L RV+ VRG G+EVIT
Sbjct: 1027 EVIVTRSHDARLVLLNMPGPP--KNSEGDENYMEFLEVLTESLERVLLVRGGGREVIT 1082
>gi|4827006|ref|NP_005063.1| solute carrier family 12
(potassium/chloride transporters), member 4 [Homo
sapiens]
gi|27151691|sp|Q9UP95|S124_HUMAN Solute carrier family 12 member 4
(Electroneutral potassium-chloride cotransporter 1)
(Erythroid K-Cl cotransporter 1) (hKCC1)
gi|1399212|gb|AAC50563.1| K-Cl cotransporter
gi|2921847|gb|AAC32815.1| erythroid K:Cl cotransporter [Homo sapiens]
gi|18203690|gb|AAH21193.1| Solute carrier family 12
(potassium/chloride transporters), member 4 [Homo
sapiens]
Length = 1085
Score = 745 bits (1924), Expect = 0.0
Identities = 427/1025 (41%), Positives = 606/1025 (58%), Gaps = 35/1025 (3%)
Frame = +1
Query: 31 HITPGPLERAQSSSHGGHGAKA----DLGVLLGVYLPTIQHILGVTMFIRLFWLVGIAGL 198
++T G E ++ S G +A +G L+GVYLP +Q+I GV +F+RL W+VG AG+
Sbjct: 91 NLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGV 150
Query: 199 GQXXXXXXXXXXXXXXXXISISAVATNGVVESGGAYFMISRNLGPEFGSAVGILFYLANT 378
Q IS+SA+ATNGVV +GG+YFMISR+LGPEFG AVG+ FYL T
Sbjct: 151 LQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTT 210
Query: 379 VATSMYLVGGVEILLLYIFPGLTFGGVEGQHDTSMFGTMTNSLRFYSTILLLIEFAIVAM 558
A +MY++G +EILL YI P G HDTS N++R Y TI L +V +
Sbjct: 211 FAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTS--NATLNNMRVYGTIFLTFMTLVVFV 268
Query: 559 GVKFVQMLAPVSLVCVILSILACYAGGVTKTIYPDSGQYVCMYNDRLLQSSAVLNESIPL 738
GVK+V A + L CVI+SIL+ YAGG+ K+I+ VCM +R L
Sbjct: 269 GVKYVNKFASLFLACVIISILSIYAGGI-KSIFDPPVFPVCMLGNRTLSRDQ-------F 320
Query: 739 DEICNYCNINNTFLADRVCGGRCNST--TIPHVSPFRCIN------GFPGFQGGQTLLEN 894
D ++N +A ++ C+S T P+ +N G PG G L EN
Sbjct: 321 DICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAG-VLQEN 379
Query: 895 LGPNYLEKGEAA--HGT-QADTKS-------DVYQDVRTSFFVLLAIYFPAVTGIFTGAN 1044
L YLEKG+ HG AD S V D+ TSF VL+ I+FP+VTGI G+N
Sbjct: 380 LWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGSN 439
Query: 1045 MSGDLKNPQASIPAGTIAANLTTSFVYFSLAFIFGGAIDNAVLRDKNGQSVGGQMVVALL 1224
SGDL++ Q SIP GTI A +TTS VYFS +FG I+ VLRDK G V +VV L
Sbjct: 440 RSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTL 499
Query: 1225 SWPSPWVLLIGSFLSTFGAALQCLCSAPRLLQAIAKDEVIPLLSPFKKVTANNEPFXXXX 1404
+WPSPWV++IGSF ST GA LQ L APRLLQAIAKD +IP L F N EP
Sbjct: 500 AWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALL 559
Query: 1405 XXXXXXXXXXXMGSMDTIAAVVDFFFLMCYAFVNIICTLHSLLGAPNWRPRFKYYHWFLS 1584
+ S+D +A ++ FFLMCY FVN+ C + +LL PNWRPRFKYYHW LS
Sbjct: 560 LTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALS 619
Query: 1585 LLGAVLCFFIMFSTHWDYAIVACLLCLVIYKYVEWKGAKKEWGDGIRGLALTTAQYSLMK 1764
LG LC +MF + W YA+VA L+ +IYKY+E++GA+KEWGDGIRGL+L+ A+Y+L++
Sbjct: 620 FLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLR 679
Query: 1765 IEDKEPHPKNWRPQLLLLLSMQWSKEIIDVRYLNLLNLASQLKAGKGLTVVTAFLQGD-P 1941
+E+ PH KNWRPQLL+LL + E + V+Y LL ASQLKAGKGLT+V + +QG
Sbjct: 680 LEEGPPHTKNWRPQLLVLLKLD---EDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFL 736
Query: 1942 TSPDDKKKGEQVKARMDFDMNQVRLRGFAKTLVHSEDQVRGSMSTLVQSVGLGGLKPNTM 2121
S + + EQ M M +++GF + +V S +VR ++ L+QS GLGG++ N++
Sbjct: 737 ESYGEAQAAEQTIKNM---MEIEKVKGFCQVVVAS--KVREGLAHLIQSCGLGGMRHNSV 791
Query: 2122 LISWPVHERE-EDMTEYNTFIEKVHAASINDMAIVVAKGIIDFPSAVFR-MSGMIDVYWI 2295
++ WP R+ ED + TFI+ V + +A++V K I +PS R + G IDV+WI
Sbjct: 792 VLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWI 851
Query: 2296 VHDGGLCLLMGYLLKQHKVWRGCKLRVIGIAQESDNNVKMQEDLQKYVYQLRIDAKIMIV 2475
VHDGG+ +L+ +LL+QHKVWR C++R+ +AQ DN+++M++DL ++Y LR++A++ +V
Sbjct: 852 VHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEVV 911
Query: 2476 ELADPEISKNAFERTLLMEERTMMMRDLQKVSGGGMSLSLPPANAPRAPSPLVTSERRAN 2655
E+ + +IS +ERTL+ME+R+ M+R ++ R + +R +
Sbjct: 912 EMHNSDISAYTYERTLMMEQRSQMLRQMRL------------TKTEREREAQLVKDRHSA 959
Query: 2656 SKXXXXXXXXXXXXXXXXXXXXXXXXQANQETKT-----KKERMKAL-----DRSKVSKM 2805
+ + T+T + + L D+S V +M
Sbjct: 960 LRLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRM 1019
Query: 2806 HTAVRLNELLLQHSANSQLILLNLPKPPVHKDQQALDDYVHYLEVMTDKLNRVIFVRGTG 2985
HTAV+LNE+++ S +++L+LLN+P PP ++ + ++Y+ +LEV+T+ L RV+ VRG G
Sbjct: 1020 HTAVKLNEVIVTRSHDARLVLLNMPGPP--RNSEGDENYMEFLEVLTEGLERVLLVRGGG 1077
Query: 2986 KEVIT 3000
+EVIT
Sbjct: 1078 REVIT 1082
>gi|6677993|ref|NP_033221.1| solute carrier family 12, member 4 [Mus
musculus]
gi|27151689|sp|Q9JIS8|S124_MOUSE Solute carrier family 12 member 4
(Electroneutral potassium-chloride cotransporter 1)
(Erythroid K-Cl cotransporter 1) (mKCC1)
gi|2921849|gb|AAC32816.1| erythroid K:Cl cotransporter [Mus musculus]
gi|6049053|gb|AAF02444.1| K-Cl cotransporter KCC1 [Mus musculus]
Length = 1085
Score = 745 bits (1923), Expect = 0.0
Identities = 427/1018 (41%), Positives = 605/1018 (58%), Gaps = 28/1018 (2%)
Frame = +1
Query: 31 HITPGPLERAQSSSHGG---HGAKA-DLGVLLGVYLPTIQHILGVTMFIRLFWLVGIAGL 198
++T G E ++ S G AKA +G L+GVYLP +Q+I GV +F+RL W+VG AG+
Sbjct: 91 NLTQGAKEHEEAESGEGGRRRAAKAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGV 150
Query: 199 GQXXXXXXXXXXXXXXXXISISAVATNGVVESGGAYFMISRNLGPEFGSAVGILFYLANT 378
Q IS+SA+ATNGVV +GG+YFMISR+LGPEFG AVG+ FYL T
Sbjct: 151 LQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTT 210
Query: 379 VATSMYLVGGVEILLLYIFPGLTFGGVEGQHDTSMFGTMTNSLRFYSTILLLIEFAIVAM 558
A +MY++G +EILL YI P G HD S N++R Y TI L + +V +
Sbjct: 211 FAAAMYILGAIEILLTYIAPPAAIFYPSGTHDMS--SATLNNMRVYGTIFLTLMTLVVFV 268
Query: 559 GVKFVQMLAPVSLVCVILSILACYAGGVTKTIYPDSGQYVCMYNDRLLQSSAVLNESIPL 738
GVK+V A + L CVI+SIL+ YAGG+ K+I+ VCM +R L
Sbjct: 269 GVKYVNKFASLFLACVIISILSIYAGGI-KSIFDPPVFPVCMLGNRTLSRDQ-------F 320
Query: 739 DEICNYCNINNTFLADRVCGGRCNST--TIPHVSPFRCIN------GFPGFQGGQTLLEN 894
D ++N +A R+ C+S T P+ +N G PG G L EN
Sbjct: 321 DICAKTVVVDNETVATRLWTFFCHSPNLTADSCDPYFLLNNVTEIPGIPGAAAG-VLQEN 379
Query: 895 LGPNYLEKGEAAH----------GTQADTKSDVYQDVRTSFFVLLAIYFPAVTGIFTGAN 1044
L YLEKGE G + V D+ TSF VL+ I+FP+VTGI G+N
Sbjct: 380 LWSAYLEKGEVVEKHGLPSTDTLGLKESLSLYVVADIATSFTVLVGIFFPSVTGIMAGSN 439
Query: 1045 MSGDLKNPQASIPAGTIAANLTTSFVYFSLAFIFGGAIDNAVLRDKNGQSVGGQMVVALL 1224
SGDL++ Q SIP GTI A +TTS VYFS +FG I+ VLRDK G V +VV L
Sbjct: 440 RSGDLRDAQKSIPVGTILAIVTTSLVYFSSVILFGACIEGVVLRDKYGDGVSRNLVVGTL 499
Query: 1225 SWPSPWVLLIGSFLSTFGAALQCLCSAPRLLQAIAKDEVIPLLSPFKKVTANNEPFXXXX 1404
+WPSPWV+++GSF ST GA LQ L APRLLQAIAKD +IP L F AN EP
Sbjct: 500 AWPSPWVIVVGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKANGEPTWALL 559
Query: 1405 XXXXXXXXXXXMGSMDTIAAVVDFFFLMCYAFVNIICTLHSLLGAPNWRPRFKYYHWFLS 1584
+ S+D +A ++ FFLMCY FVN+ C + +LL PNWRPRFKYYHW LS
Sbjct: 560 LTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWTLS 619
Query: 1585 LLGAVLCFFIMFSTHWDYAIVACLLCLVIYKYVEWKGAKKEWGDGIRGLALTTAQYSLMK 1764
LG LC +MF + W YA+VA L+ +IYKY+E++GA+KEWGDGIRGL+L+ A+Y+L++
Sbjct: 620 FLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLR 679
Query: 1765 IEDKEPHPKNWRPQLLLLLSMQWSKEIIDVRYLNLLNLASQLKAGKGLTVVTAFLQGD-P 1941
+E+ PH KNWRPQLL+LL + E + V+Y LL ASQLKAGKGLT+V + +QG
Sbjct: 680 LEEGPPHTKNWRPQLLVLLKLD---EDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFL 736
Query: 1942 TSPDDKKKGEQ-VKARMDFDMNQVRLRGFAKTLVHSEDQVRGSMSTLVQSVGLGGLKPNT 2118
S + + EQ +K MD + +++GF + +V S+ VR ++ L+QS GLGG++ N+
Sbjct: 737 ESYGEAQAAEQTIKNMMDIE----KVKGFCQVVVASK--VREGLAHLIQSCGLGGMRHNS 790
Query: 2119 MLISWPVHERE-EDMTEYNTFIEKVHAASINDMAIVVAKGIIDFPSAVFR-MSGMIDVYW 2292
+++ WP R+ ED + TFI+ V + +A++V K I +PS R + G IDV+W
Sbjct: 791 VVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLDGHIDVWW 850
Query: 2293 IVHDGGLCLLMGYLLKQHKVWRGCKLRVIGIAQESDNNVKMQEDLQKYVYQLRIDAKIMI 2472
IVHDGG+ +L+ +LL+QHKVW+ C++R+ +AQ DN+++M++DL ++Y LR++A++ +
Sbjct: 851 IVHDGGMLMLLPFLLRQHKVWKKCRMRIFTVAQMDDNSIQMKKDLAIFLYHLRLEAEVEV 910
Query: 2473 VELADPEISKNAFERTLLMEERTMMMRD--LQKVSGGGMSLSLPPANAPRAPSPLVTSER 2646
VE+ + +IS +ERTL+ME+R+ M+R L K + + ++ L + E
Sbjct: 911 VEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTERDREAQLVKDRHSALRLESLYSDEE 970
Query: 2647 RANSKXXXXXXXXXXXXXXXXXXXXXXXXQANQETKTKKERMKALDRSKVSKMHTAVRLN 2826
+ N + D+S V +MHTAV+LN
Sbjct: 971 EESVAGADKIQMTWTRDKYMAEPWDPSHAPDNFRELVHIKP----DQSNVRRMHTAVKLN 1026
Query: 2827 ELLLQHSANSQLILLNLPKPPVHKDQQALDDYVHYLEVMTDKLNRVIFVRGTGKEVIT 3000
E+++ S +++L+LLN+P PP K+ + ++Y+ +LEV+T+ L RV+ VRG G+EVIT
Sbjct: 1027 EVIVTRSHDARLVLLNMPGPP--KNSEGDENYMEFLEVLTEGLERVLLVRGGGREVIT 1082
>gi|31324218|gb|AAP47188.1| potassium-chloride cotransporter-1 [Ovis
aries]
Length = 1086
Score = 741 bits (1914), Expect = 0.0
Identities = 429/1034 (41%), Positives = 600/1034 (57%), Gaps = 44/1034 (4%)
Frame = +1
Query: 31 HITPGPLERAQSSSHGG---HGAKA-DLGVLLGVYLPTIQHILGVTMFIRLFWLVGIAGL 198
++T G E ++ S G AKA +G L+GVYLP +Q+I GV +F+RL W+VG AG+
Sbjct: 91 NLTQGAKEHEEAESGEGARRRAAKAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGV 150
Query: 199 GQXXXXXXXXXXXXXXXXISISAVATNGVVESGGAYFMISRNLGPEFGSAVGILFYLANT 378
Q IS+SA+ATNGVV +GG+YFMISR+LGPEFG AVG+ FYL T
Sbjct: 151 LQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTT 210
Query: 379 VATSMYLVGGVEILLLYIFPGLTFGGVEGQHDTSMFGTMTNSLRFYSTILLLIEFAIVAM 558
A +MY++G +EILL YI P G HDTS N++R Y TI L +V +
Sbjct: 211 FAAAMYILGAIEILLTYIAPPAAIFYPTGTHDTS--SATLNNMRVYGTIFLTFMTLVVFV 268
Query: 559 GVKFVQMLAPVSLVCVILSILACYAGGVTKTIYPDSGQYVCMYNDRLLQSSAVLNESIPL 738
GVK+V A + L CVI+SIL+ YAGG+ K+I+ VCM +R L
Sbjct: 269 GVKYVNKFASLFLACVIISILSIYAGGI-KSIFDPPIFPVCMLGNRTLSRDQ-------F 320
Query: 739 DEICNYCNINNTFLADRVCGGRCNSTTIPHVS--PFRCIN------GFPGFQGGQTLLEN 894
D ++N +A ++ C+S + S P+ +N G PG G L EN
Sbjct: 321 DVCAKTTVVDNETVATQLWSLFCHSPNLTAESCDPYFLLNNVTEIPGIPGAAAG-VLQEN 379
Query: 895 LGPNYLEKGEA----------AHGTQADTKSDVYQDVRTSFFVLLAIYFPAVTGIFTGAN 1044
L YLEKGE A G + V D+ TSF VL+ I+FP+VTGI G+N
Sbjct: 380 LWSAYLEKGEVVEKHGLPSTDALGLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGSN 439
Query: 1045 MSGDLKNPQASIPAGTIAANLTTSFVYFSLAFIFGGAIDNAVLRDKNGQSVGGQMVVALL 1224
SGDL++ Q SIP GTI A +TTS VYFS +FG I+ VLRDK G V +VV L
Sbjct: 440 RSGDLRDAQKSIPVGTILAIVTTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTL 499
Query: 1225 SWPSPWVLLIGSFLSTFGAALQCLCSAPRLLQAIAKDEVIPLLSPFKKVTANNEPFXXXX 1404
+WPSPWV++IGSF ST GA LQ L APRLLQ IAKD +IP L F AN EP
Sbjct: 500 AWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQTIAKDNIIPFLRVFGHGKANGEPTWALL 559
Query: 1405 XXXXXXXXXXXMGSMDTIAAVVDFFFLMCYAFVNIICTLHSLLGAPNWRPRFKYYHWFLS 1584
+ S+D +A ++ FFLMCY FVN+ C + +LL PNWRPRFKYYHW LS
Sbjct: 560 LTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALS 619
Query: 1585 LLGAVLCFFIMFSTHWDYAIVACLLCLVIYKYVEWKGAKKEWGDGIRGLALTTAQYSLMK 1764
LG LC +MF + W YA+VA L+ +IYKY+E++GA+KEWGDGIRGL+L+ A+Y+L++
Sbjct: 620 FLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLR 679
Query: 1765 IEDKEPHPKNWRPQLLLLLSMQWSKEIIDVRYLNLLNLASQLKAGKGLTVVTAFLQGD-P 1941
+E+ PH KNWRPQLL+LL + E + V+Y LL ASQLKAGKGLT+V + +QG
Sbjct: 680 LEEGPPHTKNWRPQLLVLLKLD---EDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFL 736
Query: 1942 TSPDDKKKGEQVKARMDFDMNQVRLRGFAKTLVHSEDQVRGSMSTLVQSVGLGGLKPNTM 2121
S + + EQ M M + +GF + +V S +VR ++ L+QS GLGG++ NT+
Sbjct: 737 ESYGEAQAAEQTTKNM---MEIEKAKGFCQVVVAS--KVREGLAHLIQSCGLGGMRHNTV 791
Query: 2122 LISWPVHERE-EDMTEYNTFIEKVHAASINDMAIVVAKGIIDFPSAVFR-MSGMIDVYWI 2295
++ WP R+ ED + FI+ V + +A++V K I +PS R + G IDV+WI
Sbjct: 792 VLGWPYGWRQSEDPRAWKNFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWI 851
Query: 2296 VHDGGLCLLMGYLLKQHKVWRGCKLRVIGIAQESDNNVKMQEDLQKYVYQLRIDAKIMIV 2475
VHDGG+ +L+ +LL+QHKVWR C++R+ +AQ DN+++M++DL ++Y LR++A++ +V
Sbjct: 852 VHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAIFLYHLRLEAEVEVV 911
Query: 2476 ELADPEISKNAFERTLLMEERTMMMRDLQKVSGGGMSLSLPPANAPRAPSPLVTSERRAN 2655
E+ + +IS +ERTL+ME+R+ M+R ++ ER A
Sbjct: 912 EMHNSDISAYTYERTLMMEQRSQMLRQMRLTK--------------------TEREREAQ 951
Query: 2656 SKXXXXXXXXXXXXXXXXXXXXXXXXQANQETKTKKERMKA------------------- 2778
Q T T+ + M
Sbjct: 952 LVKDRHSALRLESLSSDEEDESAAGTDKIQMTWTRDKYMATEPWYPSHTPDNFRELVHIK 1011
Query: 2779 LDRSKVSKMHTAVRLNELLLQHSANSQLILLNLPKPPVHKDQQALDDYVHYLEVMTDKLN 2958
++S V +MHTAV+LNE+++ S +++L+LLN+P PP K+ + ++Y+ +LEV+T+ L
Sbjct: 1012 PNQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPP--KNSEGDENYMEFLEVLTEGLE 1069
Query: 2959 RVIFVRGTGKEVIT 3000
RV+ VRG G+EVIT
Sbjct: 1070 RVLLVRGGGREVIT 1083
>gi|48096020|ref|XP_394587.1| similar to CG5594-PC [Apis mellifera]
Length = 1107
Score = 738 bits (1905), Expect = 0.0
Identities = 424/1024 (41%), Positives = 602/1024 (58%), Gaps = 55/1024 (5%)
Frame = +1
Query: 94 ADLGVLLGVYLPTIQHILGVTMFIRLFWLVGIAGLGQXXXXXXXXXXXXXXXXISISAVA 273
A +G L+GV+LP IQ+I GV +FIRL W+VG AG Q IS+SA+A
Sbjct: 116 ARMGTLIGVFLPCIQNIFGVILFIRLTWVVGTAGAFQGFFIVLCCCCVTMLTAISMSAIA 175
Query: 274 TNGVVESGGAYFMISRNLGPEFGSAVGILFYLANTVATSMYLVGGVEILLLYIFPGLTFG 453
TNGVV +GG+YFMISR+LGPEFG AVG+LFY T+A +MY++G VEI+L Y+ P L+
Sbjct: 176 TNGVVPAGGSYFMISRSLGPEFGGAVGMLFYTGTTLAAAMYIIGAVEIVLTYMAPSLSIF 235
Query: 454 GVEGQHDTSMFGTMTNSLRFYSTILLLIEFAIVAMGVKFVQMLAPVSLVCVILSILACYA 633
G + M+ N+ R Y T LL++ IV +GVKFV A V+L CVILSI+A Y
Sbjct: 236 GDFTKDPNIMY----NNFRVYGTGLLMVMGTIVFIGVKFVNKFATVALACVILSIVAVYV 291
Query: 634 GGVTKTIYPDSGQYVCMYNDRLLQSSAVLNESIPLDEICNYCNINNTFLADRV-CGGRCN 810
G +C+ RLL+ VL E CN N + + ++ CG
Sbjct: 292 G-------------MCVLGRRLLKDINVLTE----------CNKNTSGILHQLYCGNTTT 328
Query: 811 STTIPHV--SPFRCINGFPGFQGGQTLLENLGPNYLEKGEA-AHGTQA--------DTKS 957
S P+ + ING G G L+N+ ++ E+G+ A+G + +
Sbjct: 329 SKCDPYYMENDVTIINGIRGLASG-VFLDNIWDSFQEEGQLIAYGRDPKDIDMMSNSSFN 387
Query: 958 DVYQDVRTSFFVLLAIYFPAVTGIFTGANMSGDLKNPQASIPAGTIAANLTTSFVYFSLA 1137
+ D+ T+F +L+ I+FP+VTGI G+N SGDL + Q SIP GTI A LTTS VY S
Sbjct: 388 QIQVDLTTTFTILIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTICAILTTSTVYLSSV 447
Query: 1138 FIFGGAIDNAVLRDKNGQSVGGQMVVALLSWPSPWVLLIGSFLSTFGAALQCLCSAPRLL 1317
+F G +DN +LRDK GQS+GG++VVA ++WP+ WV+LIGSFLST GA LQ L APRLL
Sbjct: 448 LLFAGTVDNLLLRDKFGQSIGGKLVVANMAWPNQWVILIGSFLSTLGAGLQSLTGAPRLL 507
Query: 1318 QAIAKDEVIPLLSPFKKVTANNEPFXXXXXXXXXXXXXXXMGSMDTIAAVVDFFFLMCYA 1497
QAIAKD +IP L+PF ++ EP +G++D +A ++ FFLMCY
Sbjct: 508 QAIAKDSIIPFLTPFATSSSRGEPTRALVLTVIICQCGILLGNVDYLAPLLSMFFLMCYG 567
Query: 1498 FVNIICTLHSLLGAPNWRPRFKYYHWFLSLLGAVLCFFIMFSTHWDYAIVACLLCLVIYK 1677
FVN+ C L +LL PNWRPRFKYYHW LS LG LC IMF T W YA++A + IYK
Sbjct: 568 FVNLACALQTLLRTPNWRPRFKYYHWSLSFLGLSLCIAIMFMTSWYYALLAMGMAGCIYK 627
Query: 1678 YVEWKGAKKEWGDGIRGLALTTAQYSLMKIEDKEPHPKNWRPQLLLLLSMQWSKEIIDVR 1857
Y+E++GA+KEWGDGIRGLAL+ A+YSL+++E+ PH KNWRPQ+L+L + + + +
Sbjct: 628 YIEYRGAEKEWGDGIRGLALSAARYSLLRLEEGPPHTKNWRPQILILAKL---TDDLVPK 684
Query: 1858 YLNLLNLASQLKAGKGLTVVTAFLQGDPTSPDDKKKGEQVKARMDFDMNQVRLRGFAKTL 2037
Y L ASQLKAGKGLT+ + + GD K +V R + + +++GF L
Sbjct: 685 YRKLFAFASQLKAGKGLTICVSCIGGDYIQNTGKTLAAKVNLRK--TIAEEKVKGFVDVL 742
Query: 2038 VHSEDQVRGSMSTLVQSVGLGGLKPNTMLISWPVH-EREEDMTEYNTFIEKVHAASINDM 2214
V ++D V G + +L+Q+ GLGG+KPNT+++ WP ++ ++ + F++ V A + M
Sbjct: 743 V-AKDVVDG-LCSLIQTTGLGGMKPNTVILGWPYSWKQSQEERNWRGFLQTVRAVAAARM 800
Query: 2215 AIVVAKGIIDFPSAVFRMSGMIDVYWIVHDGGLCLLMGYLLKQHKVWRGCKLRVIGIAQE 2394
A++V KGI FP + ++ G IDV+WIVHDGGL +L+ +LLKQH+ W+ CK+R+ +AQ
Sbjct: 801 ALLVPKGINFFPDSTEKVVGNIDVWWIVHDGGLLMLLPFLLKQHRTWKNCKMRIFTVAQM 860
Query: 2395 SDNNVKMQEDLQKYVYQLRIDAKIMIVELADPEISKNAFERTLLMEERTMMMRDL---QK 2565
DN+++M++DL+K++Y LRI+A++ IVE+ D +IS +ERTL+ME+R M+R+L +K
Sbjct: 861 EDNSIQMKKDLKKFLYDLRIEAEVEIVEMMDSDISAYTYERTLMMEQRNQMLRELRLNKK 920
Query: 2566 VSGGGMSL----------------------SLPPANAPRAPSPLV--TSERRANSKXXXX 2673
S G + S P A LV T + +
Sbjct: 921 ESLGVVQAIVDHHHNVDVKVATKVRFQEPGSQNPNAVDEAQEKLVQETEGKEGEADVNDG 980
Query: 2674 XXXXXXXXXXXXXXXXXXXXQANQET--KTKKERMKALDRSKVSK-------------MH 2808
Q N+E K KE + S SK MH
Sbjct: 981 GEEAKEGNEEETKLIGGSPKQENKENTEKEAKENEEKKTDSPESKKPTITPDEGNVRRMH 1040
Query: 2809 TAVRLNELLLQHSANSQLILLNLPKPPVHKDQQALDDYVHYLEVMTDKLNRVIFVRGTGK 2988
T+++LNE++++ S N+QL++LNLP PP + +Y+ +LEV+T+ L RV+ VRG G+
Sbjct: 1041 TSIKLNEVIVKKSKNAQLVILNLPGPPRDTKLERESNYMEFLEVLTEGLERVLMVRGGGR 1100
Query: 2989 EVIT 3000
EVIT
Sbjct: 1101 EVIT 1104
>gi|9507107|ref|NP_062102.1| solute carrier family 12, member 4
[Rattus norvegicus]
gi|27151681|sp|Q63632|S124_RAT Solute carrier family 12 member 4
(Electroneutral potassium-chloride cotransporter 1)
(Erythroid K-Cl cotransporter 1) (rKCC1)
(Furosemide-sensitive K-Cl cotransporter)
gi|7513994|pir||T31429 K-Cl cotransport protein KCC1,
furosemide-sensitive - rat
gi|1403707|gb|AAC52634.1| furosemide-sensitive K-Cl cotransporter
Length = 1085
Score = 737 bits (1903), Expect = 0.0
Identities = 423/1017 (41%), Positives = 597/1017 (58%), Gaps = 27/1017 (2%)
Frame = +1
Query: 31 HITPGPLERAQSSSHGG---HGAKA-DLGVLLGVYLPTIQHILGVTMFIRLFWLVGIAGL 198
++T G E ++ S G AKA +G L+GVYLP +Q+I GV +F+RL W+VG AG+
Sbjct: 91 NLTQGAKEHEEAESGEGGRRRAAKAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGV 150
Query: 199 GQXXXXXXXXXXXXXXXXISISAVATNGVVESGGAYFMISRNLGPEFGSAVGILFYLANT 378
Q IS+SA+ATNGVV +GG+YFMISR+LGPEFG AVG+ FYL T
Sbjct: 151 LQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTT 210
Query: 379 VATSMYLVGGVEILLLYIFPGLTFGGVEGQHDTSMFGTMTNSLRFYSTILLLIEFAIVAM 558
A +MY++G +EILL YI P G HD S N++R Y TI L +V +
Sbjct: 211 FAAAMYILGAIEILLTYIAPPAAIFYPSGTHDMS--SATLNNMRVYGTIFLTFMTLVVFV 268
Query: 559 GVKFVQMLAPVSLVCVILSILACYAGGVTKTIYPDSGQYVCMYNDRLLQSSAVLNESIPL 738
GVK+V A + L CVI+SIL+ Y GG+ P VCM +R L
Sbjct: 269 GVKYVNKFASLFLACVIISILSIYVGGIKSAFDPPVFP-VCMLGNRTLSRDQ-------F 320
Query: 739 DEICNYCNINNTFLADRVCGGRCNST--TIPHVSPFRCIN------GFPGFQGGQTLLEN 894
D ++N +A R+ C+S T P+ +N G PG G L EN
Sbjct: 321 DICAKTVVVDNETVATRLWTFFCHSPNLTADSCDPYFLLNNVTEIPGIPGAAAG-VLQEN 379
Query: 895 LGPNYLEKGEAAH----------GTQADTKSDVYQDVRTSFFVLLAIYFPAVTGIFTGAN 1044
L YLEKGE G + V D+ TSF VL+ I+FP+VTGI G+N
Sbjct: 380 LWSAYLEKGEVVEKHGLPSTDTLGLKESLSLYVVADIATSFTVLVGIFFPSVTGIMAGSN 439
Query: 1045 MSGDLKNPQASIPAGTIAANLTTSFVYFSLAFIFGGAIDNAVLRDKNGQSVGGQMVVALL 1224
SGDL++ Q SIP GTI A +TTS VYFS +FG I+ VLRDK G V +VV L
Sbjct: 440 RSGDLRDAQKSIPVGTILAIVTTSLVYFSSVILFGACIEGVVLRDKYGDGVSRNLVVGTL 499
Query: 1225 SWPSPWVLLIGSFLSTFGAALQCLCSAPRLLQAIAKDEVIPLLSPFKKVTANNEPFXXXX 1404
+WPSPWV+++GSF ST GA LQ L APRLLQAIAKD +IP L F AN EP
Sbjct: 500 AWPSPWVIVVGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKANGEPTWALL 559
Query: 1405 XXXXXXXXXXXMGSMDTIAAVVDFFFLMCYAFVNIICTLHSLLGAPNWRPRFKYYHWFLS 1584
+ S+D +A ++ FFLMCY FVN+ C + +LL PNWRPRFKYYHW LS
Sbjct: 560 LTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALS 619
Query: 1585 LLGAVLCFFIMFSTHWDYAIVACLLCLVIYKYVEWKGAKKEWGDGIRGLALTTAQYSLMK 1764
LG LC +MF + W YA+VA ++ +IYKY+E++GA+KEWGDGIRGL+L+ A+Y+L++
Sbjct: 620 FLGMSLCLALMFVSSWYYALVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLR 679
Query: 1765 IEDKEPHPKNWRPQLLLLLSMQWSKEIIDVRYLNLLNLASQLKAGKGLTVVTAFLQGD-P 1941
+E+ PH KNWRPQLL+LL + E + V+Y LL ASQLKAGKGLT+V + +QG
Sbjct: 680 LEEGPPHTKNWRPQLLVLLKLD---EDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFL 736
Query: 1942 TSPDDKKKGEQVKARMDFDMNQVRLRGFAKTLVHSEDQVRGSMSTLVQSVGLGGLKPNTM 2121
S + + EQ M M +++GF + +V S+ VR ++ L+QS GLGG++ N++
Sbjct: 737 ESYGEAQAAEQTIKNM---MEIEKVKGFCQVVVASK--VREGLAHLIQSCGLGGMRHNSV 791
Query: 2122 LISWPVHERE-EDMTEYNTFIEKVHAASINDMAIVVAKGIIDFPSAVFR-MSGMIDVYWI 2295
++ WP R+ ED + TFI+ V + +A++V K I +PS R + G IDV+WI
Sbjct: 792 VLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWI 851
Query: 2296 VHDGGLCLLMGYLLKQHKVWRGCKLRVIGIAQESDNNVKMQEDLQKYVYQLRIDAKIMIV 2475
VHDGG+ +L+ +LL+QHKVW+ C++R+ +AQ DN+++M++DL ++Y LR++A++ +V
Sbjct: 852 VHDGGMLMLLPFLLRQHKVWKKCRMRIFTVAQMDDNSIQMKKDLAIFLYHLRLEAEVEVV 911
Query: 2476 ELADPEISKNAFERTLLMEERTMMMRD--LQKVSGGGMSLSLPPANAPRAPSPLVTSERR 2649
E+ + +IS +ERTL+ME+R+ M+R L K + + ++ L + E
Sbjct: 912 EMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTERDREAQLVKDRHSALRLESLYSDEED 971
Query: 2650 ANSKXXXXXXXXXXXXXXXXXXXXXXXXQANQETKTKKERMKALDRSKVSKMHTAVRLNE 2829
+ N + D+S V +MHTAV+LNE
Sbjct: 972 ESVTGADKIQMTWTRDKYMAEPWDPSHAPDNFRELVHIKP----DQSNVRRMHTAVKLNE 1027
Query: 2830 LLLQHSANSQLILLNLPKPPVHKDQQALDDYVHYLEVMTDKLNRVIFVRGTGKEVIT 3000
+++ S +++L+LLN+P PP K+ + ++Y+ +LEV+T+ L RV+ VRG G+EVIT
Sbjct: 1028 VIVTRSHDARLVLLNMPGPP--KNSEGDENYMEFLEVLTEGLERVLLVRGGGREVIT 1082
>gi|4826780|ref|NP_005126.1| potassium chloride cotransporter KCC3;
agenesis of corpus callosum and peripheral neuropathy
(Andermann syndrome) [Homo sapiens]
gi|4585229|gb|AAD25337.1| K:Cl cotransporter 3 [Homo sapiens]
gi|22416428|gb|AAM96216.1| potassium-chloride transporter-3b [Homo
sapiens]
Length = 1099
Score = 736 bits (1901), Expect = 0.0
Identities = 422/994 (42%), Positives = 590/994 (58%), Gaps = 27/994 (2%)
Frame = +1
Query: 100 LGVLLGVYLPTIQHILGVTMFIRLFWLVGIAGLGQXXXXXXXXXXXXXXXXISISAVATN 279
+G +GVYLP +Q+I GV +F+RL W+VG AG+ Q IS+SA+ATN
Sbjct: 134 MGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATN 193
Query: 280 GVVESGGAYFMISRNLGPEFGSAVGILFYLANTVATSMYLVGGVEILLLYIFPGLTFGGV 459
GVV +GG+YFMISR LGPEFG AVG+ FYL T A +MY++G +EI L+YI P
Sbjct: 194 GVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHS 253
Query: 460 EGQHDTSMFGTMTNSLRFYSTILLLIEFAIVAMGVKFVQMLAPVSLVCVILSILACYAGG 639
+ S M N++R Y T L++ +V +GV++V A + L CVI+SILA YAG
Sbjct: 254 DDALKES--AAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGA 311
Query: 640 VTKTIYPDSGQYVCMYNDRLLQSSAVLNESIPLDEICNYCN-INNTFLADRVCGGRCNST 816
+ + P VCM +R L S + ++C+ INN + ++ G CNS+
Sbjct: 312 IKSSFAPPHFP-VCMLGNRTLSSRHI--------DVCSKTKEINNMTVPSKLWGFFCNSS 362
Query: 817 TIPHVS--------PFRCINGFPGFQGGQTLLENLGPNYLEKGEAAHGTQADTKSD---- 960
+ + I G PG G + ENL NYL KGE A +
Sbjct: 363 QFFNATCDEYFVHNNVTSIQGIPGLASG-IITENLWSNYLPKGEIIEKPSAKSSDVLGSL 421
Query: 961 ----VYQDVRTSFFVLLAIYFPAVTGIFTGANMSGDLKNPQASIPAGTIAANLTTSFVYF 1128
V D+ TSF +L+ I+FP+VTGI G+N SGDLK+ Q SIP GTI A LTTSFVY
Sbjct: 422 NHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYL 481
Query: 1129 SLAFIFGGAIDNAVLRDKNGQSVGGQMVVALLSWPSPWVLLIGSFLSTFGAALQCLCSAP 1308
S +FG I+ VLRDK G +V G +VV LSWPSPWV++IGSF ST GA LQ L AP
Sbjct: 482 SNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAP 541
Query: 1309 RLLQAIAKDEVIPLLSPFKKVTANNEPFXXXXXXXXXXXXXXXMGSMDTIAAVVDFFFLM 1488
RLLQAIAKD +IP L F AN EP + S+D +A ++ FFLM
Sbjct: 542 RLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLM 601
Query: 1489 CYAFVNIICTLHSLLGAPNWRPRFKYYHWFLSLLGAVLCFFIMFSTHWDYAIVACLLCLV 1668
CY FVN+ C L +LL PNWRPRF+YYHW LS +G +C +MF + W YAIVA ++ +
Sbjct: 602 CYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGM 661
Query: 1669 IYKYVEWKGAKKEWGDGIRGLALTTAQYSLMKIEDKEPHPKNWRPQLLLLLSMQWSKEII 1848
IYKY+E++GA+KEWGDGIRGL+L+ A+++L+++E+ PH KNWRPQLL+LL + E +
Sbjct: 662 IYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLD---EDL 718
Query: 1849 DVRYLNLLNLASQLKAGKGLTVVTAFLQGDPTSPDDKKKGEQVKARMDFD--MNQVRLRG 2022
V++ LL ASQLKAGKGLT+V + + G+ + GE + A M +++G
Sbjct: 719 HVKHPRLLTFASQLKAGKGLTIVGSVIVGNFL----ENYGEALAAEQTIKHLMEAEKVKG 774
Query: 2023 FAKTLVHSEDQVRGSMSTLVQSVGLGGLKPNTMLISWPVHERE-EDMTEYNTFIEKVHAA 2199
F + +V + ++R +S L+QS GLGG+K NT+++ WP R+ ED + TFI V
Sbjct: 775 FCQLVVAA--KLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVT 832
Query: 2200 SINDMAIVVAKGIIDFPSAVFRMS-GMIDVYWIVHDGGLCLLMGYLLKQHKVWRGCKLRV 2376
+ +A++VAK I FPS V + S G IDV+WIVHDGG+ +L+ +LLKQHKVWR C +R+
Sbjct: 833 TAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRI 892
Query: 2377 IGIAQESDNNVKMQEDLQKYVYQLRIDAKIMIVELADPEISKNAFERTLLMEERTMMMRD 2556
+AQ DN+++M++DL ++Y LRI+A++ +VE+ D +IS +ERTL+ME+R+ M+R
Sbjct: 893 FTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRH 952
Query: 2557 LQKVSGGGMSLSLPPANAPRAPSPLVTSERRANSKXXXXXXXXXXXXXXXXXXXXXXXXQ 2736
M LS + S R S
Sbjct: 953 --------MRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYM 1004
Query: 2737 ANQETKTKK-ERMKAL-----DRSKVSKMHTAVRLNELLLQHSANSQLILLNLPKPPVHK 2898
A++ K K E + L D+S V +MHTAV+LNE+++ S ++L+LLN+P PP +
Sbjct: 1005 ASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPP--R 1062
Query: 2899 DQQALDDYVHYLEVMTDKLNRVIFVRGTGKEVIT 3000
+ + ++Y+ +LEV+T+ L RV+ VRG G EVIT
Sbjct: 1063 NPEGDENYMEFLEVLTEGLERVLLVRGGGSEVIT 1096
>gi|7512561|pir||T17275 hypothetical protein DKFZp434D2135.1 - human
(fragment)
gi|5912006|emb|CAB55965.1| hypothetical protein [Homo sapiens]
Length = 1014
Score = 736 bits (1901), Expect = 0.0
Identities = 422/994 (42%), Positives = 590/994 (58%), Gaps = 27/994 (2%)
Frame = +1
Query: 100 LGVLLGVYLPTIQHILGVTMFIRLFWLVGIAGLGQXXXXXXXXXXXXXXXXISISAVATN 279
+G +GVYLP +Q+I GV +F+RL W+VG AG+ Q IS+SA+ATN
Sbjct: 49 MGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATN 108
Query: 280 GVVESGGAYFMISRNLGPEFGSAVGILFYLANTVATSMYLVGGVEILLLYIFPGLTFGGV 459
GVV +GG+YFMISR LGPEFG AVG+ FYL T A +MY++G +EI L+YI P
Sbjct: 109 GVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHS 168
Query: 460 EGQHDTSMFGTMTNSLRFYSTILLLIEFAIVAMGVKFVQMLAPVSLVCVILSILACYAGG 639
+ S M N++R Y T L++ +V +GV++V A + L CVI+SILA YAG
Sbjct: 169 DDALKES--AAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGA 226
Query: 640 VTKTIYPDSGQYVCMYNDRLLQSSAVLNESIPLDEICNYCN-INNTFLADRVCGGRCNST 816
+ + P VCM +R L S + ++C+ INN + ++ G CNS+
Sbjct: 227 IKSSFAPPHFP-VCMLGNRTLSSRHI--------DVCSKTKEINNMTVPSKLWGFFCNSS 277
Query: 817 TIPHVS--------PFRCINGFPGFQGGQTLLENLGPNYLEKGEAAHGTQADTKSD---- 960
+ + I G PG G + ENL NYL KGE A +
Sbjct: 278 QFFNATCDEYFVHNNVTSIQGIPGLASG-IITENLWSNYLPKGEIIEKPSAKSSDVLGSL 336
Query: 961 ----VYQDVRTSFFVLLAIYFPAVTGIFTGANMSGDLKNPQASIPAGTIAANLTTSFVYF 1128
V D+ TSF +L+ I+FP+VTGI G+N SGDLK+ Q SIP GTI A LTTSFVY
Sbjct: 337 NHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYL 396
Query: 1129 SLAFIFGGAIDNAVLRDKNGQSVGGQMVVALLSWPSPWVLLIGSFLSTFGAALQCLCSAP 1308
S +FG I+ VLRDK G +V G +VV LSWPSPWV++IGSF ST GA LQ L AP
Sbjct: 397 SNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAP 456
Query: 1309 RLLQAIAKDEVIPLLSPFKKVTANNEPFXXXXXXXXXXXXXXXMGSMDTIAAVVDFFFLM 1488
RLLQAIAKD +IP L F AN EP + S+D +A ++ FFLM
Sbjct: 457 RLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLM 516
Query: 1489 CYAFVNIICTLHSLLGAPNWRPRFKYYHWFLSLLGAVLCFFIMFSTHWDYAIVACLLCLV 1668
CY FVN+ C L +LL PNWRPRF+YYHW LS +G +C +MF + W YAIVA ++ +
Sbjct: 517 CYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGM 576
Query: 1669 IYKYVEWKGAKKEWGDGIRGLALTTAQYSLMKIEDKEPHPKNWRPQLLLLLSMQWSKEII 1848
IYKY+E++GA+KEWGDGIRGL+L+ A+++L+++E+ PH KNWRPQLL+LL + E +
Sbjct: 577 IYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLD---EDL 633
Query: 1849 DVRYLNLLNLASQLKAGKGLTVVTAFLQGDPTSPDDKKKGEQVKARMDFD--MNQVRLRG 2022
V++ LL ASQLKAGKGLT+V + + G+ + GE + A M +++G
Sbjct: 634 HVKHPRLLTFASQLKAGKGLTIVGSVIVGNFL----ENYGEALAAEQTIKHLMEAEKVKG 689
Query: 2023 FAKTLVHSEDQVRGSMSTLVQSVGLGGLKPNTMLISWPVHERE-EDMTEYNTFIEKVHAA 2199
F + +V + ++R +S L+QS GLGG+K NT+++ WP R+ ED + TFI V
Sbjct: 690 FCQLVVAA--KLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVT 747
Query: 2200 SINDMAIVVAKGIIDFPSAVFRMS-GMIDVYWIVHDGGLCLLMGYLLKQHKVWRGCKLRV 2376
+ +A++VAK I FPS V + S G IDV+WIVHDGG+ +L+ +LLKQHKVWR C +R+
Sbjct: 748 TAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRI 807
Query: 2377 IGIAQESDNNVKMQEDLQKYVYQLRIDAKIMIVELADPEISKNAFERTLLMEERTMMMRD 2556
+AQ DN+++M++DL ++Y LRI+A++ +VE+ D +IS +ERTL+ME+R+ M+R
Sbjct: 808 FTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRH 867
Query: 2557 LQKVSGGGMSLSLPPANAPRAPSPLVTSERRANSKXXXXXXXXXXXXXXXXXXXXXXXXQ 2736
M LS + S R S
Sbjct: 868 --------MRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYM 919
Query: 2737 ANQETKTKK-ERMKAL-----DRSKVSKMHTAVRLNELLLQHSANSQLILLNLPKPPVHK 2898
A++ K K E + L D+S V +MHTAV+LNE+++ S ++L+LLN+P PP +
Sbjct: 920 ASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPP--R 977
Query: 2899 DQQALDDYVHYLEVMTDKLNRVIFVRGTGKEVIT 3000
+ + ++Y+ +LEV+T+ L RV+ VRG G EVIT
Sbjct: 978 NPEGDENYMEFLEVLTEGLERVLLVRGGGSEVIT 1011
>gi|27151690|sp|Q9UHW9|S126_HUMAN Solute carrier family 12 member 6
(Electroneutral potassium-chloride cotransporter 3) (K-Cl
cotransporter 3)
gi|5106523|gb|AAD39742.1| K-Cl cotransporter KCC3a [Homo sapiens]
gi|22416427|gb|AAM96215.1| potassium-chloride transporter-3a [Homo
sapiens]
Length = 1150
Score = 736 bits (1901), Expect = 0.0
Identities = 422/994 (42%), Positives = 590/994 (58%), Gaps = 27/994 (2%)
Frame = +1
Query: 100 LGVLLGVYLPTIQHILGVTMFIRLFWLVGIAGLGQXXXXXXXXXXXXXXXXISISAVATN 279
+G +GVYLP +Q+I GV +F+RL W+VG AG+ Q IS+SA+ATN
Sbjct: 185 MGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATN 244
Query: 280 GVVESGGAYFMISRNLGPEFGSAVGILFYLANTVATSMYLVGGVEILLLYIFPGLTFGGV 459
GVV +GG+YFMISR LGPEFG AVG+ FYL T A +MY++G +EI L+YI P
Sbjct: 245 GVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHS 304
Query: 460 EGQHDTSMFGTMTNSLRFYSTILLLIEFAIVAMGVKFVQMLAPVSLVCVILSILACYAGG 639
+ S M N++R Y T L++ +V +GV++V A + L CVI+SILA YAG
Sbjct: 305 DDALKES--AAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGA 362
Query: 640 VTKTIYPDSGQYVCMYNDRLLQSSAVLNESIPLDEICNYCN-INNTFLADRVCGGRCNST 816
+ + P VCM +R L S + ++C+ INN + ++ G CNS+
Sbjct: 363 IKSSFAPPHFP-VCMLGNRTLSSRHI--------DVCSKTKEINNMTVPSKLWGFFCNSS 413
Query: 817 TIPHVS--------PFRCINGFPGFQGGQTLLENLGPNYLEKGEAAHGTQADTKSD---- 960
+ + I G PG G + ENL NYL KGE A +
Sbjct: 414 QFFNATCDEYFVHNNVTSIQGIPGLASG-IITENLWSNYLPKGEIIEKPSAKSSDVLGSL 472
Query: 961 ----VYQDVRTSFFVLLAIYFPAVTGIFTGANMSGDLKNPQASIPAGTIAANLTTSFVYF 1128
V D+ TSF +L+ I+FP+VTGI G+N SGDLK+ Q SIP GTI A LTTSFVY
Sbjct: 473 NHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYL 532
Query: 1129 SLAFIFGGAIDNAVLRDKNGQSVGGQMVVALLSWPSPWVLLIGSFLSTFGAALQCLCSAP 1308
S +FG I+ VLRDK G +V G +VV LSWPSPWV++IGSF ST GA LQ L AP
Sbjct: 533 SNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAP 592
Query: 1309 RLLQAIAKDEVIPLLSPFKKVTANNEPFXXXXXXXXXXXXXXXMGSMDTIAAVVDFFFLM 1488
RLLQAIAKD +IP L F AN EP + S+D +A ++ FFLM
Sbjct: 593 RLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLM 652
Query: 1489 CYAFVNIICTLHSLLGAPNWRPRFKYYHWFLSLLGAVLCFFIMFSTHWDYAIVACLLCLV 1668
CY FVN+ C L +LL PNWRPRF+YYHW LS +G +C +MF + W YAIVA ++ +
Sbjct: 653 CYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGM 712
Query: 1669 IYKYVEWKGAKKEWGDGIRGLALTTAQYSLMKIEDKEPHPKNWRPQLLLLLSMQWSKEII 1848
IYKY+E++GA+KEWGDGIRGL+L+ A+++L+++E+ PH KNWRPQLL+LL + E +
Sbjct: 713 IYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLD---EDL 769
Query: 1849 DVRYLNLLNLASQLKAGKGLTVVTAFLQGDPTSPDDKKKGEQVKARMDFD--MNQVRLRG 2022
V++ LL ASQLKAGKGLT+V + + G+ + GE + A M +++G
Sbjct: 770 HVKHPRLLTFASQLKAGKGLTIVGSVIVGNFL----ENYGEALAAEQTIKHLMEAEKVKG 825
Query: 2023 FAKTLVHSEDQVRGSMSTLVQSVGLGGLKPNTMLISWPVHERE-EDMTEYNTFIEKVHAA 2199
F + +V + ++R +S L+QS GLGG+K NT+++ WP R+ ED + TFI V
Sbjct: 826 FCQLVVAA--KLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVT 883
Query: 2200 SINDMAIVVAKGIIDFPSAVFRMS-GMIDVYWIVHDGGLCLLMGYLLKQHKVWRGCKLRV 2376
+ +A++VAK I FPS V + S G IDV+WIVHDGG+ +L+ +LLKQHKVWR C +R+
Sbjct: 884 TAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRI 943
Query: 2377 IGIAQESDNNVKMQEDLQKYVYQLRIDAKIMIVELADPEISKNAFERTLLMEERTMMMRD 2556
+AQ DN+++M++DL ++Y LRI+A++ +VE+ D +IS +ERTL+ME+R+ M+R
Sbjct: 944 FTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRH 1003
Query: 2557 LQKVSGGGMSLSLPPANAPRAPSPLVTSERRANSKXXXXXXXXXXXXXXXXXXXXXXXXQ 2736
M LS + S R S
Sbjct: 1004 --------MRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYM 1055
Query: 2737 ANQETKTKK-ERMKAL-----DRSKVSKMHTAVRLNELLLQHSANSQLILLNLPKPPVHK 2898
A++ K K E + L D+S V +MHTAV+LNE+++ S ++L+LLN+P PP +
Sbjct: 1056 ASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPP--R 1113
Query: 2899 DQQALDDYVHYLEVMTDKLNRVIFVRGTGKEVIT 3000
+ + ++Y+ +LEV+T+ L RV+ VRG G EVIT
Sbjct: 1114 NPEGDENYMEFLEVLTEGLERVLLVRGGGSEVIT 1147
>gi|33329254|gb|AAQ10027.1| K-Cl cotransporter KCC3a-S1 isoform [Homo
sapiens]
gi|33329256|gb|AAQ10028.1| K-Cl cotransporter KCC3a-S2 isoform [Homo
sapiens]
Length = 1091
Score = 736 bits (1901), Expect = 0.0
Identities = 422/994 (42%), Positives = 590/994 (58%), Gaps = 27/994 (2%)
Frame = +1
Query: 100 LGVLLGVYLPTIQHILGVTMFIRLFWLVGIAGLGQXXXXXXXXXXXXXXXXISISAVATN 279
+G +GVYLP +Q+I GV +F+RL W+VG AG+ Q IS+SA+ATN
Sbjct: 126 MGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATN 185
Query: 280 GVVESGGAYFMISRNLGPEFGSAVGILFYLANTVATSMYLVGGVEILLLYIFPGLTFGGV 459
GVV +GG+YFMISR LGPEFG AVG+ FYL T A +MY++G +EI L+YI P
Sbjct: 186 GVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHS 245
Query: 460 EGQHDTSMFGTMTNSLRFYSTILLLIEFAIVAMGVKFVQMLAPVSLVCVILSILACYAGG 639
+ S M N++R Y T L++ +V +GV++V A + L CVI+SILA YAG
Sbjct: 246 DDALKES--AAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGA 303
Query: 640 VTKTIYPDSGQYVCMYNDRLLQSSAVLNESIPLDEICNYCN-INNTFLADRVCGGRCNST 816
+ + P VCM +R L S + ++C+ INN + ++ G CNS+
Sbjct: 304 IKSSFAPPHFP-VCMLGNRTLSSRHI--------DVCSKTKEINNMTVPSKLWGFFCNSS 354
Query: 817 TIPHVS--------PFRCINGFPGFQGGQTLLENLGPNYLEKGEAAHGTQADTKSD---- 960
+ + I G PG G + ENL NYL KGE A +
Sbjct: 355 QFFNATCDEYFVHNNVTSIQGIPGLASG-IITENLWSNYLPKGEIIEKPSAKSSDVLGSL 413
Query: 961 ----VYQDVRTSFFVLLAIYFPAVTGIFTGANMSGDLKNPQASIPAGTIAANLTTSFVYF 1128
V D+ TSF +L+ I+FP+VTGI G+N SGDLK+ Q SIP GTI A LTTSFVY
Sbjct: 414 NHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYL 473
Query: 1129 SLAFIFGGAIDNAVLRDKNGQSVGGQMVVALLSWPSPWVLLIGSFLSTFGAALQCLCSAP 1308
S +FG I+ VLRDK G +V G +VV LSWPSPWV++IGSF ST GA LQ L AP
Sbjct: 474 SNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAP 533
Query: 1309 RLLQAIAKDEVIPLLSPFKKVTANNEPFXXXXXXXXXXXXXXXMGSMDTIAAVVDFFFLM 1488
RLLQAIAKD +IP L F AN EP + S+D +A ++ FFLM
Sbjct: 534 RLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLM 593
Query: 1489 CYAFVNIICTLHSLLGAPNWRPRFKYYHWFLSLLGAVLCFFIMFSTHWDYAIVACLLCLV 1668
CY FVN+ C L +LL PNWRPRF+YYHW LS +G +C +MF + W YAIVA ++ +
Sbjct: 594 CYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGM 653
Query: 1669 IYKYVEWKGAKKEWGDGIRGLALTTAQYSLMKIEDKEPHPKNWRPQLLLLLSMQWSKEII 1848
IYKY+E++GA+KEWGDGIRGL+L+ A+++L+++E+ PH KNWRPQLL+LL + E +
Sbjct: 654 IYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLD---EDL 710
Query: 1849 DVRYLNLLNLASQLKAGKGLTVVTAFLQGDPTSPDDKKKGEQVKARMDFD--MNQVRLRG 2022
V++ LL ASQLKAGKGLT+V + + G+ + GE + A M +++G
Sbjct: 711 HVKHPRLLTFASQLKAGKGLTIVGSVIVGNFL----ENYGEALAAEQTIKHLMEAEKVKG 766
Query: 2023 FAKTLVHSEDQVRGSMSTLVQSVGLGGLKPNTMLISWPVHERE-EDMTEYNTFIEKVHAA 2199
F + +V + ++R +S L+QS GLGG+K NT+++ WP R+ ED + TFI V
Sbjct: 767 FCQLVVAA--KLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVT 824
Query: 2200 SINDMAIVVAKGIIDFPSAVFRMS-GMIDVYWIVHDGGLCLLMGYLLKQHKVWRGCKLRV 2376
+ +A++VAK I FPS V + S G IDV+WIVHDGG+ +L+ +LLKQHKVWR C +R+
Sbjct: 825 TAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRI 884
Query: 2377 IGIAQESDNNVKMQEDLQKYVYQLRIDAKIMIVELADPEISKNAFERTLLMEERTMMMRD 2556
+AQ DN+++M++DL ++Y LRI+A++ +VE+ D +IS +ERTL+ME+R+ M+R
Sbjct: 885 FTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRH 944
Query: 2557 LQKVSGGGMSLSLPPANAPRAPSPLVTSERRANSKXXXXXXXXXXXXXXXXXXXXXXXXQ 2736
M LS + S R S
Sbjct: 945 --------MRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYM 996
Query: 2737 ANQETKTKK-ERMKAL-----DRSKVSKMHTAVRLNELLLQHSANSQLILLNLPKPPVHK 2898
A++ K K E + L D+S V +MHTAV+LNE+++ S ++L+LLN+P PP +
Sbjct: 997 ASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPP--R 1054
Query: 2899 DQQALDDYVHYLEVMTDKLNRVIFVRGTGKEVIT 3000
+ + ++Y+ +LEV+T+ L RV+ VRG G EVIT
Sbjct: 1055 NPEGDENYMEFLEVLTEGLERVLLVRGGGSEVIT 1088
>gi|19110891|gb|AAL85335.1| K-Cl cotransporter KCC3 variant isoform
[Homo sapiens]
Length = 1011
Score = 736 bits (1901), Expect = 0.0
Identities = 422/994 (42%), Positives = 590/994 (58%), Gaps = 27/994 (2%)
Frame = +1
Query: 100 LGVLLGVYLPTIQHILGVTMFIRLFWLVGIAGLGQXXXXXXXXXXXXXXXXISISAVATN 279
+G +GVYLP +Q+I GV +F+RL W+VG AG+ Q IS+SA+ATN
Sbjct: 46 MGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATN 105
Query: 280 GVVESGGAYFMISRNLGPEFGSAVGILFYLANTVATSMYLVGGVEILLLYIFPGLTFGGV 459
GVV +GG+YFMISR LGPEFG AVG+ FYL T A +MY++G +EI L+YI P
Sbjct: 106 GVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHS 165
Query: 460 EGQHDTSMFGTMTNSLRFYSTILLLIEFAIVAMGVKFVQMLAPVSLVCVILSILACYAGG 639
+ S M N++R Y T L++ +V +GV++V A + L CVI+SILA YAG
Sbjct: 166 DDALKES--AAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGA 223
Query: 640 VTKTIYPDSGQYVCMYNDRLLQSSAVLNESIPLDEICNYCN-INNTFLADRVCGGRCNST 816
+ + P VCM +R L S + ++C+ INN + ++ G CNS+
Sbjct: 224 IKSSFAPPHFP-VCMLGNRTLSSRHI--------DVCSKTKEINNMTVPSKLWGFFCNSS 274
Query: 817 TIPHVS--------PFRCINGFPGFQGGQTLLENLGPNYLEKGEAAHGTQADTKSD---- 960
+ + I G PG G + ENL NYL KGE A +
Sbjct: 275 QFFNATCDEYFVHNNVTSIQGIPGLASG-IITENLWSNYLPKGEIIEKPSAKSSDVLGSL 333
Query: 961 ----VYQDVRTSFFVLLAIYFPAVTGIFTGANMSGDLKNPQASIPAGTIAANLTTSFVYF 1128
V D+ TSF +L+ I+FP+VTGI G+N SGDLK+ Q SIP GTI A LTTSFVY
Sbjct: 334 NHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYL 393
Query: 1129 SLAFIFGGAIDNAVLRDKNGQSVGGQMVVALLSWPSPWVLLIGSFLSTFGAALQCLCSAP 1308
S +FG I+ VLRDK G +V G +VV LSWPSPWV++IGSF ST GA LQ L AP
Sbjct: 394 SNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAP 453
Query: 1309 RLLQAIAKDEVIPLLSPFKKVTANNEPFXXXXXXXXXXXXXXXMGSMDTIAAVVDFFFLM 1488
RLLQAIAKD +IP L F AN EP + S+D +A ++ FFLM
Sbjct: 454 RLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLM 513
Query: 1489 CYAFVNIICTLHSLLGAPNWRPRFKYYHWFLSLLGAVLCFFIMFSTHWDYAIVACLLCLV 1668
CY FVN+ C L +LL PNWRPRF+YYHW LS +G +C +MF + W YAIVA ++ +
Sbjct: 514 CYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGM 573
Query: 1669 IYKYVEWKGAKKEWGDGIRGLALTTAQYSLMKIEDKEPHPKNWRPQLLLLLSMQWSKEII 1848
IYKY+E++GA+KEWGDGIRGL+L+ A+++L+++E+ PH KNWRPQLL+LL + E +
Sbjct: 574 IYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLD---EDL 630
Query: 1849 DVRYLNLLNLASQLKAGKGLTVVTAFLQGDPTSPDDKKKGEQVKARMDFD--MNQVRLRG 2022
V++ LL ASQLKAGKGLT+V + + G+ + GE + A M +++G
Sbjct: 631 HVKHPRLLTFASQLKAGKGLTIVGSVIVGNFL----ENYGEALAAEQTIKHLMEAEKVKG 686
Query: 2023 FAKTLVHSEDQVRGSMSTLVQSVGLGGLKPNTMLISWPVHERE-EDMTEYNTFIEKVHAA 2199
F + +V + ++R +S L+QS GLGG+K NT+++ WP R+ ED + TFI V
Sbjct: 687 FCQLVVAA--KLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVT 744
Query: 2200 SINDMAIVVAKGIIDFPSAVFRMS-GMIDVYWIVHDGGLCLLMGYLLKQHKVWRGCKLRV 2376
+ +A++VAK I FPS V + S G IDV+WIVHDGG+ +L+ +LLKQHKVWR C +R+
Sbjct: 745 TAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRI 804
Query: 2377 IGIAQESDNNVKMQEDLQKYVYQLRIDAKIMIVELADPEISKNAFERTLLMEERTMMMRD 2556
+AQ DN+++M++DL ++Y LRI+A++ +VE+ D +IS +ERTL+ME+R+ M+R
Sbjct: 805 FTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRH 864
Query: 2557 LQKVSGGGMSLSLPPANAPRAPSPLVTSERRANSKXXXXXXXXXXXXXXXXXXXXXXXXQ 2736
M LS + S R S
Sbjct: 865 --------MRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYM 916
Query: 2737 ANQETKTKK-ERMKAL-----DRSKVSKMHTAVRLNELLLQHSANSQLILLNLPKPPVHK 2898
A++ K K E + L D+S V +MHTAV+LNE+++ S ++L+LLN+P PP +
Sbjct: 917 ASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPP--R 974
Query: 2899 DQQALDDYVHYLEVMTDKLNRVIFVRGTGKEVIT 3000
+ + ++Y+ +LEV+T+ L RV+ VRG G EVIT
Sbjct: 975 NPEGDENYMEFLEVLTEGLERVLLVRGGGSEVIT 1008
>gi|33329252|gb|AAQ10026.1| K-Cl cotransporter KCC3a-X2M isoform [Homo
sapiens]
Length = 1135
Score = 736 bits (1901), Expect = 0.0
Identities = 422/994 (42%), Positives = 590/994 (58%), Gaps = 27/994 (2%)
Frame = +1
Query: 100 LGVLLGVYLPTIQHILGVTMFIRLFWLVGIAGLGQXXXXXXXXXXXXXXXXISISAVATN 279
+G +GVYLP +Q+I GV +F+RL W+VG AG+ Q IS+SA+ATN
Sbjct: 170 MGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATN 229
Query: 280 GVVESGGAYFMISRNLGPEFGSAVGILFYLANTVATSMYLVGGVEILLLYIFPGLTFGGV 459
GVV +GG+YFMISR LGPEFG AVG+ FYL T A +MY++G +EI L+YI P
Sbjct: 230 GVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHS 289
Query: 460 EGQHDTSMFGTMTNSLRFYSTILLLIEFAIVAMGVKFVQMLAPVSLVCVILSILACYAGG 639
+ S M N++R Y T L++ +V +GV++V A + L CVI+SILA YAG
Sbjct: 290 DDALKES--AAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGA 347
Query: 640 VTKTIYPDSGQYVCMYNDRLLQSSAVLNESIPLDEICNYCN-INNTFLADRVCGGRCNST 816
+ + P VCM +R L S + ++C+ INN + ++ G CNS+
Sbjct: 348 IKSSFAPPHFP-VCMLGNRTLSSRHI--------DVCSKTKEINNMTVPSKLWGFFCNSS 398
Query: 817 TIPHVS--------PFRCINGFPGFQGGQTLLENLGPNYLEKGEAAHGTQADTKSD---- 960
+ + I G PG G + ENL NYL KGE A +
Sbjct: 399 QFFNATCDEYFVHNNVTSIQGIPGLASG-IITENLWSNYLPKGEIIEKPSAKSSDVLGSL 457
Query: 961 ----VYQDVRTSFFVLLAIYFPAVTGIFTGANMSGDLKNPQASIPAGTIAANLTTSFVYF 1128
V D+ TSF +L+ I+FP+VTGI G+N SGDLK+ Q SIP GTI A LTTSFVY
Sbjct: 458 NHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYL 517
Query: 1129 SLAFIFGGAIDNAVLRDKNGQSVGGQMVVALLSWPSPWVLLIGSFLSTFGAALQCLCSAP 1308
S +FG I+ VLRDK G +V G +VV LSWPSPWV++IGSF ST GA LQ L AP
Sbjct: 518 SNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAP 577
Query: 1309 RLLQAIAKDEVIPLLSPFKKVTANNEPFXXXXXXXXXXXXXXXMGSMDTIAAVVDFFFLM 1488
RLLQAIAKD +IP L F AN EP + S+D +A ++ FFLM
Sbjct: 578 RLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLM 637
Query: 1489 CYAFVNIICTLHSLLGAPNWRPRFKYYHWFLSLLGAVLCFFIMFSTHWDYAIVACLLCLV 1668
CY FVN+ C L +LL PNWRPRF+YYHW LS +G +C +MF + W YAIVA ++ +
Sbjct: 638 CYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGM 697
Query: 1669 IYKYVEWKGAKKEWGDGIRGLALTTAQYSLMKIEDKEPHPKNWRPQLLLLLSMQWSKEII 1848
IYKY+E++GA+KEWGDGIRGL+L+ A+++L+++E+ PH KNWRPQLL+LL + E +
Sbjct: 698 IYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLD---EDL 754
Query: 1849 DVRYLNLLNLASQLKAGKGLTVVTAFLQGDPTSPDDKKKGEQVKARMDFD--MNQVRLRG 2022
V++ LL ASQLKAGKGLT+V + + G+ + GE + A M +++G
Sbjct: 755 HVKHPRLLTFASQLKAGKGLTIVGSVIVGNFL----ENYGEALAAEQTIKHLMEAEKVKG 810
Query: 2023 FAKTLVHSEDQVRGSMSTLVQSVGLGGLKPNTMLISWPVHERE-EDMTEYNTFIEKVHAA 2199
F + +V + ++R +S L+QS GLGG+K NT+++ WP R+ ED + TFI V
Sbjct: 811 FCQLVVAA--KLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVT 868
Query: 2200 SINDMAIVVAKGIIDFPSAVFRMS-GMIDVYWIVHDGGLCLLMGYLLKQHKVWRGCKLRV 2376
+ +A++VAK I FPS V + S G IDV+WIVHDGG+ +L+ +LLKQHKVWR C +R+
Sbjct: 869 TAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRI 928
Query: 2377 IGIAQESDNNVKMQEDLQKYVYQLRIDAKIMIVELADPEISKNAFERTLLMEERTMMMRD 2556
+AQ DN+++M++DL ++Y LRI+A++ +VE+ D +IS +ERTL+ME+R+ M+R
Sbjct: 929 FTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRH 988
Query: 2557 LQKVSGGGMSLSLPPANAPRAPSPLVTSERRANSKXXXXXXXXXXXXXXXXXXXXXXXXQ 2736
M LS + S R S
Sbjct: 989 --------MRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYM 1040
Query: 2737 ANQETKTKK-ERMKAL-----DRSKVSKMHTAVRLNELLLQHSANSQLILLNLPKPPVHK 2898
A++ K K E + L D+S V +MHTAV+LNE+++ S ++L+LLN+P PP +
Sbjct: 1041 ASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPP--R 1098
Query: 2899 DQQALDDYVHYLEVMTDKLNRVIFVRGTGKEVIT 3000
+ + ++Y+ +LEV+T+ L RV+ VRG G EVIT
Sbjct: 1099 NPEGDENYMEFLEVLTEGLERVLLVRGGGSEVIT 1132
>gi|6693798|gb|AAF24986.1| K-Cl cotransporter KCC3 [Homo sapiens]
Length = 1150
Score = 736 bits (1899), Expect = 0.0
Identities = 422/994 (42%), Positives = 589/994 (58%), Gaps = 27/994 (2%)
Frame = +1
Query: 100 LGVLLGVYLPTIQHILGVTMFIRLFWLVGIAGLGQXXXXXXXXXXXXXXXXISISAVATN 279
+G +GVYLP +Q+I GV +F+RL W+VG AG+ Q IS+SA+ATN
Sbjct: 185 MGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATN 244
Query: 280 GVVESGGAYFMISRNLGPEFGSAVGILFYLANTVATSMYLVGGVEILLLYIFPGLTFGGV 459
GVV +GG+YFMISR LGPEFG AVG+ FYL T A +MY++G +EI L+YI P
Sbjct: 245 GVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHS 304
Query: 460 EGQHDTSMFGTMTNSLRFYSTILLLIEFAIVAMGVKFVQMLAPVSLVCVILSILACYAGG 639
+ S M N++R Y T L++ +V +GV++V A + L CVI+SILA YAG
Sbjct: 305 DDALKES--AAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGA 362
Query: 640 VTKTIYPDSGQYVCMYNDRLLQSSAVLNESIPLDEICNYCN-INNTFLADRVCGGRCNST 816
+ + P VCM +R L S + ++C+ INN + ++ G CNS+
Sbjct: 363 IKSSFAPPHFP-VCMLGNRTLSSRHI--------DVCSKTKEINNMTVPSKLWGFFCNSS 413
Query: 817 TIPHVS--------PFRCINGFPGFQGGQTLLENLGPNYLEKGEAAHGTQADTKSD---- 960
+ + I G PG G + ENL NYL KGE A +
Sbjct: 414 QFFNATCDEYFVHNNVTSIQGIPGLASG-IITENLWSNYLPKGEIIEKPSAKSSDVLGSL 472
Query: 961 ----VYQDVRTSFFVLLAIYFPAVTGIFTGANMSGDLKNPQASIPAGTIAANLTTSFVYF 1128
V D+ TSF +L+ I+FP+VTGI G+N SGDLK+ Q SIP GTI A LTTSFVY
Sbjct: 473 NHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYL 532
Query: 1129 SLAFIFGGAIDNAVLRDKNGQSVGGQMVVALLSWPSPWVLLIGSFLSTFGAALQCLCSAP 1308
S +FG I+ VLRDK G +V G +VV LSWPSPWV++IGSF ST GA LQ L AP
Sbjct: 533 SNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAP 592
Query: 1309 RLLQAIAKDEVIPLLSPFKKVTANNEPFXXXXXXXXXXXXXXXMGSMDTIAAVVDFFFLM 1488
RLLQAIAKD +IP L F AN EP + S+D +A ++ FFLM
Sbjct: 593 RLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLM 652
Query: 1489 CYAFVNIICTLHSLLGAPNWRPRFKYYHWFLSLLGAVLCFFIMFSTHWDYAIVACLLCLV 1668
CY FVN+ C L +LL PNWRPRF+YYHW LS +G +C +MF + W YAIVA ++ +
Sbjct: 653 CYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGM 712
Query: 1669 IYKYVEWKGAKKEWGDGIRGLALTTAQYSLMKIEDKEPHPKNWRPQLLLLLSMQWSKEII 1848
IYKY+E++GA+KEWGDGIRGL+L+ A+++L+++E+ PH KNWRPQLL+LL + E +
Sbjct: 713 IYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLD---EDL 769
Query: 1849 DVRYLNLLNLASQLKAGKGLTVVTAFLQGDPTSPDDKKKGEQVKARMDFD--MNQVRLRG 2022
V++ LL ASQLKAGKGLT+V + + G+ GE + A M +++G
Sbjct: 770 HVKHPRLLTFASQLKAGKGLTIVGSVIVGNFL----HNYGEALAAEQTIKHLMEAEKVKG 825
Query: 2023 FAKTLVHSEDQVRGSMSTLVQSVGLGGLKPNTMLISWPVHERE-EDMTEYNTFIEKVHAA 2199
F + +V + ++R +S L+QS GLGG+K NT+++ WP R+ ED + TFI V
Sbjct: 826 FCQLVVAA--KLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVT 883
Query: 2200 SINDMAIVVAKGIIDFPSAVFRMS-GMIDVYWIVHDGGLCLLMGYLLKQHKVWRGCKLRV 2376
+ +A++VAK I FPS V + S G IDV+WIVHDGG+ +L+ +LLKQHKVWR C +R+
Sbjct: 884 TAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRI 943
Query: 2377 IGIAQESDNNVKMQEDLQKYVYQLRIDAKIMIVELADPEISKNAFERTLLMEERTMMMRD 2556
+AQ DN+++M++DL ++Y LRI+A++ +VE+ D +IS +ERTL+ME+R+ M+R
Sbjct: 944 FTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRH 1003
Query: 2557 LQKVSGGGMSLSLPPANAPRAPSPLVTSERRANSKXXXXXXXXXXXXXXXXXXXXXXXXQ 2736
M LS + S R S
Sbjct: 1004 --------MRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYM 1055
Query: 2737 ANQETKTKK-ERMKAL-----DRSKVSKMHTAVRLNELLLQHSANSQLILLNLPKPPVHK 2898
A++ K K E + L D+S V +MHTAV+LNE+++ S ++L+LLN+P PP +
Sbjct: 1056 ASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPP--R 1113
Query: 2899 DQQALDDYVHYLEVMTDKLNRVIFVRGTGKEVIT 3000
+ + ++Y+ +LEV+T+ L RV+ VRG G EVIT
Sbjct: 1114 NPEGDENYMEFLEVLTEGLERVLLVRGGGSEVIT 1147
>gi|47124056|gb|AAH70107.1| SLC12A6 protein [Homo sapiens]
Length = 1156
Score = 734 bits (1894), Expect = 0.0
Identities = 421/994 (42%), Positives = 589/994 (58%), Gaps = 27/994 (2%)
Frame = +1
Query: 100 LGVLLGVYLPTIQHILGVTMFIRLFWLVGIAGLGQXXXXXXXXXXXXXXXXISISAVATN 279
+G +GVY P +Q+I GV +F+RL W+VG AG+ Q IS+SA+ATN
Sbjct: 191 MGTFMGVYPPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATN 250
Query: 280 GVVESGGAYFMISRNLGPEFGSAVGILFYLANTVATSMYLVGGVEILLLYIFPGLTFGGV 459
GVV +GG+YFMISR LGPEFG AVG+ FYL T A +MY++G +EI L+YI P
Sbjct: 251 GVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHS 310
Query: 460 EGQHDTSMFGTMTNSLRFYSTILLLIEFAIVAMGVKFVQMLAPVSLVCVILSILACYAGG 639
+ S M N++R Y T L++ +V +GV++V A + L CVI+SILA YAG
Sbjct: 311 DDALKES--AAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGA 368
Query: 640 VTKTIYPDSGQYVCMYNDRLLQSSAVLNESIPLDEICNYCN-INNTFLADRVCGGRCNST 816
+ + P VCM +R L S + ++C+ INN + ++ G CNS+
Sbjct: 369 IKSSFAPPHFP-VCMLGNRTLSSRHI--------DVCSKTKEINNMTVPSKLWGFFCNSS 419
Query: 817 TIPHVS--------PFRCINGFPGFQGGQTLLENLGPNYLEKGEAAHGTQADTKSD---- 960
+ + I G PG G + ENL NYL KGE A +
Sbjct: 420 QFFNATCDEYFVHNNVTSIQGIPGLASG-IITENLWSNYLPKGEIIEKPSAKSSDVLGSL 478
Query: 961 ----VYQDVRTSFFVLLAIYFPAVTGIFTGANMSGDLKNPQASIPAGTIAANLTTSFVYF 1128
V D+ TSF +L+ I+FP+VTGI G+N SGDLK+ Q SIP GTI A LTTSFVY
Sbjct: 479 NHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYL 538
Query: 1129 SLAFIFGGAIDNAVLRDKNGQSVGGQMVVALLSWPSPWVLLIGSFLSTFGAALQCLCSAP 1308
S +FG I+ VLRDK G +V G +VV LSWPSPWV++IGSF ST GA LQ L AP
Sbjct: 539 SNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAP 598
Query: 1309 RLLQAIAKDEVIPLLSPFKKVTANNEPFXXXXXXXXXXXXXXXMGSMDTIAAVVDFFFLM 1488
RLLQAIAKD +IP L F AN EP + S+D +A ++ FFLM
Sbjct: 599 RLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLM 658
Query: 1489 CYAFVNIICTLHSLLGAPNWRPRFKYYHWFLSLLGAVLCFFIMFSTHWDYAIVACLLCLV 1668
CY FVN+ C L +LL PNWRPRF+YYHW LS +G +C +MF + W YAIVA ++ +
Sbjct: 659 CYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGM 718
Query: 1669 IYKYVEWKGAKKEWGDGIRGLALTTAQYSLMKIEDKEPHPKNWRPQLLLLLSMQWSKEII 1848
IYKY+E++GA+KEWGDGIRGL+L+ A+++L+++E+ PH KNWRPQLL+LL + E +
Sbjct: 719 IYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLD---EDL 775
Query: 1849 DVRYLNLLNLASQLKAGKGLTVVTAFLQGDPTSPDDKKKGEQVKARMDFD--MNQVRLRG 2022
V++ LL ASQLKAGKGLT+V + + G+ + GE + A M +++G
Sbjct: 776 HVKHPRLLTFASQLKAGKGLTIVGSVIVGNFL----ENYGEALAAEQTIKHLMEAEKVKG 831
Query: 2023 FAKTLVHSEDQVRGSMSTLVQSVGLGGLKPNTMLISWPVHERE-EDMTEYNTFIEKVHAA 2199
F + +V + ++R +S L+QS GLGG+K NT+++ WP R+ ED + TFI V
Sbjct: 832 FCQLVVAA--KLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVT 889
Query: 2200 SINDMAIVVAKGIIDFPSAVFRMS-GMIDVYWIVHDGGLCLLMGYLLKQHKVWRGCKLRV 2376
+ +A++VAK I FPS V + S G IDV+WIVHDGG+ +L+ +LLKQHKVWR C +R+
Sbjct: 890 TAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRI 949
Query: 2377 IGIAQESDNNVKMQEDLQKYVYQLRIDAKIMIVELADPEISKNAFERTLLMEERTMMMRD 2556
+AQ DN+++M++DL ++Y LRI+A++ +VE+ D +IS +ERTL+ME+R+ M+R
Sbjct: 950 FTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRH 1009
Query: 2557 LQKVSGGGMSLSLPPANAPRAPSPLVTSERRANSKXXXXXXXXXXXXXXXXXXXXXXXXQ 2736
M LS + S R S
Sbjct: 1010 --------MRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYM 1061
Query: 2737 ANQETKTKK-ERMKAL-----DRSKVSKMHTAVRLNELLLQHSANSQLILLNLPKPPVHK 2898
A++ K K E + L D+S V +MHTAV+LNE+++ S ++L+LLN+P PP +
Sbjct: 1062 ASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPP--R 1119
Query: 2899 DQQALDDYVHYLEVMTDKLNRVIFVRGTGKEVIT 3000
+ + ++Y+ +LEV+T+ L RV+ VRG G EVIT
Sbjct: 1120 NPEGDENYMEFLEVLTEGLERVLLVRGGGSEVIT 1153
>gi|5730043|ref|NP_006589.1| solute carrier family 12
(potassium/chloride transporters), member 7;
potassium/chloride transporter KCC4 [Homo sapiens]
gi|27151693|sp|Q9Y666|S127_HUMAN Solute carrier family 12 member 7
(Electroneutral potassium-chloride cotransporter 4) (K-Cl
cotransporter 4)
gi|5106521|gb|AAD39741.1| K-Cl cotransporter KCC4 [Homo sapiens]
Length = 1083
Score = 731 bits (1887), Expect = 0.0
Identities = 415/1032 (40%), Positives = 597/1032 (57%), Gaps = 33/1032 (3%)
Frame = +1
Query: 4 PFFSSYLK-----AHITPGPLERAQSSSHGGHGAKAD-LGVLLGVYLPTIQHILGVTMFI 165
P SS L +++ G +E + AKA +G +GVYLP +Q+ILGV +F+
Sbjct: 80 PMVSSLLNKLANYTNLSQGVVEHEEDEESRRREAKAPRMGTFIGVYLPCLQNILGVILFL 139
Query: 166 RLFWLVGIAGLGQXXXXXXXXXXXXXXXXISISAVATNGVVESGGAYFMISRNLGPEFGS 345
RL W+VG+AG+ + IS+SA+ATNGVV +GG+Y+MISR+LGPEFG
Sbjct: 140 RLTWIVGVAGVLESFLIVAMCCTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGG 199
Query: 346 AVGILFYLANTVATSMYLVGGVEILLLYIFPGLTFGGVEGQHDTSMFGTMTNSLRFYSTI 525
AVG+ FYL T A +MY++G +EI L YI PG E + M +++R Y T
Sbjct: 200 AVGLCFYLGTTFAGAMYILGTIEIFLTYISPGAAIFQAEAAGGEA--AAMLHNMRVYGTC 257
Query: 526 LLLIEFAIVAMGVKFVQMLAPVSLVCVILSILACYAGGVTKTIYPDSGQYVCMYNDRLLQ 705
L++ +V +GVK+V LA V L CV+LSILA YAG V K+ + VC+ +R L
Sbjct: 258 TLVLMALVVFVGVKYVNKLALVFLACVVLSILAIYAG-VIKSAFDPPDIPVCLLGNRTLS 316
Query: 706 SSAVLNESIPLDEICNYCNINNTFLADRVCGGRCNSTTIPHV-------SPFRCINGFPG 864
+ D I+N + G CN + + I G PG
Sbjct: 317 RRS-------FDACVKAYGIHNNSATSALWGLFCNGSQPSAACDEYFIQNNVTEIQGIPG 369
Query: 865 FQGGQTLLENLGPNYLEKGE-----------AAHGTQADTKSDVYQDVRTSFFVLLAIYF 1011
G LENL Y G A ++A T V D+ SF +L+ IYF
Sbjct: 370 AASG-VFLENLWSTYAHAGAFVEKKGVPSVPVAEESRASTLPYVLTDIAASFTLLVGIYF 428
Query: 1012 PAVTGIFTGANMSGDLKNPQASIPAGTIAANLTTSFVYFSLAFIFGGAIDNAVLRDKNGQ 1191
P+VTGI G+N SGDLK+ Q SIP GTI A +TTSF+Y S +FG I+ VLRDK G+
Sbjct: 429 PSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGVVLRDKFGE 488
Query: 1192 SVGGQMVVALLSWPSPWVLLIGSFLSTFGAALQCLCSAPRLLQAIAKDEVIPLLSPFKKV 1371
++ G +V+ +L+WPSPWV++IGSF ST GA LQ L APRLLQAIA+D ++P L F
Sbjct: 489 ALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQTLTGAPRLLQAIARDGIVPFLQVFGHG 548
Query: 1372 TANNEPFXXXXXXXXXXXXXXXMGSMDTIAAVVDFFFLMCYAFVNIICTLHSLLGAPNWR 1551
AN EP + S+D++A ++ FFLMCY FVN+ C + +LL PNWR
Sbjct: 549 KANGEPTWALLLTVLICETGILIASLDSVAPILSMFFLMCYLFVNLACAVQTLLRTPNWR 608
Query: 1552 PRFKYYHWFLSLLGAVLCFFIMFSTHWDYAIVACLLCLVIYKYVEWKGAKKEWGDGIRGL 1731
PRFK+YHW LS LG LC +MF W YA+ A L+ IYKY+E++GA+KEWGDGIRGL
Sbjct: 609 PRFKFYHWTLSFLGMSLCLALMFICSWYYALSAMLIAGCIYKYIEYRGAEKEWGDGIRGL 668
Query: 1732 ALTTAQYSLMKIEDKEPHPKNWRPQLLLLLSMQWSKEIIDVRYLNLLNLASQLKAGKGLT 1911
+L A+Y+L+++E PH KNWRPQ+L++L++ + V++ LL+ SQLKAGKGLT
Sbjct: 669 SLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDAEQA---VKHPRLLSFTSQLKAGKGLT 725
Query: 1912 VVTAFLQGDPTSPDDKKKGEQVKARMDFDMNQVRLRGFAKTLVHSEDQVRGSMSTLVQSV 2091
+V + L+G T D + ++ + + M+ + +GF + +V S +R MS L+QS
Sbjct: 726 IVGSVLEG--TYLDKHMEAQRAEENIRSLMSTEKTKGFCQLVVSS--SLRDGMSHLIQSA 781
Query: 2092 GLGGLKPNTMLISWPVHEREEDMT-EYNTFIEKVHAASINDMAIVVAKGIIDFPSAVFRM 2268
GLGGLK NT+L++WP ++ED + F++ V + A++VAK + FP R
Sbjct: 782 GLGGLKHNTVLMAWPASWKQEDNPFSWKNFVDTVRDTTAAHQALLVAKNVDSFPQNQERF 841
Query: 2269 -SGMIDVYWIVHDGGLCLLMGYLLKQHKVWRGCKLRVIGIAQESDNNVKMQEDLQKYVYQ 2445
G IDV+WIVHDGG+ +L+ +LL+QHKVWR C++R+ +AQ DN+++M++DLQ ++Y
Sbjct: 842 GGGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQMFLYH 901
Query: 2446 LRIDAKIMIVELADPEISKNAFERTLLMEERTMMMRDLQKVSGGGMSLSLPPANAPRAPS 2625
LRI A++ +VE+ + +IS +ERTL+ME+R+ M++ +Q N +
Sbjct: 902 LRISAEVEVVEMVENDISAFTYERTLMMEQRSQMLKQMQL-----------SKNEQEREA 950
Query: 2626 PLVTSERRANSKXXXXXXXX--XXXXXXXXXXXXXXXXQANQETKTKKERMKAL-----D 2784
L+ A+ + + T K L D
Sbjct: 951 QLIHDRNTASHTAAAARTQAPPTPDKVQMTWTREKLIAEKYRSRDTSLSGFKDLFSMKPD 1010
Query: 2785 RSKVSKMHTAVRLNELLLQHSANSQLILLNLPKPPVHKDQQALDDYVHYLEVMTDKLNRV 2964
+S V +MHTAV+LN ++L S ++QL+LLN+P PP K++Q ++Y+ +LEV+T+ LNRV
Sbjct: 1011 QSNVRRMHTAVKLNGVVLNKSQDAQLVLLNMPGPP--KNRQGDENYMEFLEVLTEGLNRV 1068
Query: 2965 IFVRGTGKEVIT 3000
+ VRG G+EVIT
Sbjct: 1069 LLVRGGGREVIT 1080
>gi|41281645|ref|NP_598410.1| solute carrier family 12, member 6 [Mus
musculus]
gi|27151686|sp|Q924N4|S126_MOUSE Solute carrier family 12 member 6
(Electroneutral potassium-chloride cotransporter 3) (K-Cl
cotransporter 3)
gi|15042077|gb|AAK81895.1| K-Cl cotransporter 3a [Mus musculus]
Length = 1150
Score = 730 bits (1885), Expect = 0.0
Identities = 419/993 (42%), Positives = 589/993 (59%), Gaps = 26/993 (2%)
Frame = +1
Query: 100 LGVLLGVYLPTIQHILGVTMFIRLFWLVGIAGLGQXXXXXXXXXXXXXXXXISISAVATN 279
+G +GVYLP +Q+I GV +F+RL W+VG AG+ Q IS+SA+ATN
Sbjct: 185 MGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGILQAFAIVLICCCCTMLTAISMSAIATN 244
Query: 280 GVVESGGAYFMISRNLGPEFGSAVGILFYLANTVATSMYLVGGVEILLLYIFPGLTFGGV 459
GVV +GG+YFMISR LGPEFG AVG+ FYL T A +MY++G +EI L+YI P
Sbjct: 245 GVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFRS 304
Query: 460 EGQHDTSMFGTMTNSLRFYSTILLLIEFAIVAMGVKFVQMLAPVSLVCVILSILACYAGG 639
+ S M N++R Y T L++ +V +GV++V A + L CVI+SILA YAG
Sbjct: 305 DDALKES--AAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGA 362
Query: 640 VTKTIYPDSGQYVCMYNDRLLQSSAVLNESIPLDEICNYCN-INNTFLADRVCGGRCNST 816
+ + P VCM +R L S + +IC+ ++N + ++ G CNS+
Sbjct: 363 IKSSFAPPHFP-VCMLGNRTLSSRHL--------DICSKTKEVDNMTVPSKLWGFFCNSS 413
Query: 817 TIPHVSPFR--------CINGFPGFQGGQTLLENLGPNYLEKGEAAHGTQADTKSD---- 960
+ + I G PG G + ENL NYL KGE A +
Sbjct: 414 QFFNATCDEYFVHNNVISIQGIPGLASG-IITENLWSNYLPKGEIIEKPSAKSSDVLGNL 472
Query: 961 ----VYQDVRTSFFVLLAIYFPAVTGIFTGANMSGDLKNPQASIPAGTIAANLTTSFVYF 1128
V D+ TSF +L+ I+FP+VTGI G+N SGDLK+ Q SIP GTI A LTTSFVY
Sbjct: 473 NHEYVLADITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYL 532
Query: 1129 SLAFIFGGAIDNAVLRDKNGQSVGGQMVVALLSWPSPWVLLIGSFLSTFGAALQCLCSAP 1308
S +FG I+ VLRDK G +V G +VV LSWPSPWV++IGSF ST GA LQ L AP
Sbjct: 533 SNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAP 592
Query: 1309 RLLQAIAKDEVIPLLSPFKKVTANNEPFXXXXXXXXXXXXXXXMGSMDTIAAVVDFFFLM 1488
RLLQAIAKD +IP L F AN EP + S+D +A ++ FFLM
Sbjct: 593 RLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLM 652
Query: 1489 CYAFVNIICTLHSLLGAPNWRPRFKYYHWFLSLLGAVLCFFIMFSTHWDYAIVACLLCLV 1668
CY FVN+ C L +LL PNWRPRF+YYHW LS +G +C +MF + W YAIVA ++ +
Sbjct: 653 CYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGM 712
Query: 1669 IYKYVEWKGAKKEWGDGIRGLALTTAQYSLMKIEDKEPHPKNWRPQLLLLLSMQWSKEII 1848
IYKY+E++GA+KEWGDGIRGL+L+ A+++L+++E+ PH KNWRPQLL+LL + E +
Sbjct: 713 IYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLD---EDL 769
Query: 1849 DVRYLNLLNLASQLKAGKGLTVVTAFLQGD-PTSPDDKKKGEQVKARMDFDMNQVRLRGF 2025
V++ LL ASQLKAGKGLT+V + + G+ + D EQ + M +++GF
Sbjct: 770 HVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGDALAAEQTIKHL---MEAEKVKGF 826
Query: 2026 AKTLVHSEDQVRGSMSTLVQSVGLGGLKPNTMLISWPVHERE-EDMTEYNTFIEKVHAAS 2202
+ +V + +++ +S L+QS GLGG+K NT+++ WP R+ ED + TFI V +
Sbjct: 827 CQLVVAA--KLKEGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTT 884
Query: 2203 INDMAIVVAKGIIDFPSAVFRMS-GMIDVYWIVHDGGLCLLMGYLLKQHKVWRGCKLRVI 2379
+A++VAK + FPS V + S G IDV WIVHDGG+ +L+ +LLKQHKVWR C +R+
Sbjct: 885 AAHLALLVAKNVSFFPSNVEQFSEGNIDVRWIVHDGGMLMLLPFLLKQHKVWRKCSIRIF 944
Query: 2380 GIAQESDNNVKMQEDLQKYVYQLRIDAKIMIVELADPEISKNAFERTLLMEERTMMMRDL 2559
+AQ DN+++M++DL ++Y LRI+A++ +VE+ D +IS +ERTL+ME+R+ M+R
Sbjct: 945 TVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRH- 1003
Query: 2560 QKVSGGGMSLSLPPANAPRAPSPLVTSERRANSKXXXXXXXXXXXXXXXXXXXXXXXXQA 2739
M LS + S R S A
Sbjct: 1004 -------MRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMA 1056
Query: 2740 NQETKTKK-ERMKAL-----DRSKVSKMHTAVRLNELLLQHSANSQLILLNLPKPPVHKD 2901
++ K K E + L D+S V +MHTAV+LNE+++ S ++L+LLN+P PP ++
Sbjct: 1057 SRGQKVKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPP--RN 1114
Query: 2902 QQALDDYVHYLEVMTDKLNRVIFVRGTGKEVIT 3000
+ ++Y+ +LEV+T+ L RV+ VRG G EVIT
Sbjct: 1115 PEGDENYMEFLEVLTEGLERVLLVRGGGSEVIT 1147
>gi|19526769|ref|NP_598409.1| solute carrier family 12, member 6 [Mus
musculus]
gi|15042079|gb|AAK81896.1| K-Cl cotransporter 3b [Mus musculus]
Length = 1099
Score = 730 bits (1885), Expect = 0.0
Identities = 419/993 (42%), Positives = 589/993 (59%), Gaps = 26/993 (2%)
Frame = +1
Query: 100 LGVLLGVYLPTIQHILGVTMFIRLFWLVGIAGLGQXXXXXXXXXXXXXXXXISISAVATN 279
+G +GVYLP +Q+I GV +F+RL W+VG AG+ Q IS+SA+ATN
Sbjct: 134 MGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGILQAFAIVLICCCCTMLTAISMSAIATN 193
Query: 280 GVVESGGAYFMISRNLGPEFGSAVGILFYLANTVATSMYLVGGVEILLLYIFPGLTFGGV 459
GVV +GG+YFMISR LGPEFG AVG+ FYL T A +MY++G +EI L+YI P
Sbjct: 194 GVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFRS 253
Query: 460 EGQHDTSMFGTMTNSLRFYSTILLLIEFAIVAMGVKFVQMLAPVSLVCVILSILACYAGG 639
+ S M N++R Y T L++ +V +GV++V A + L CVI+SILA YAG
Sbjct: 254 DDALKES--AAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGA 311
Query: 640 VTKTIYPDSGQYVCMYNDRLLQSSAVLNESIPLDEICNYCN-INNTFLADRVCGGRCNST 816
+ + P VCM +R L S + +IC+ ++N + ++ G CNS+
Sbjct: 312 IKSSFAPPHFP-VCMLGNRTLSSRHL--------DICSKTKEVDNMTVPSKLWGFFCNSS 362
Query: 817 TIPHVSPFR--------CINGFPGFQGGQTLLENLGPNYLEKGEAAHGTQADTKSD---- 960
+ + I G PG G + ENL NYL KGE A +
Sbjct: 363 QFFNATCDEYFVHNNVISIQGIPGLASG-IITENLWSNYLPKGEIIEKPSAKSSDVLGNL 421
Query: 961 ----VYQDVRTSFFVLLAIYFPAVTGIFTGANMSGDLKNPQASIPAGTIAANLTTSFVYF 1128
V D+ TSF +L+ I+FP+VTGI G+N SGDLK+ Q SIP GTI A LTTSFVY
Sbjct: 422 NHEYVLADITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYL 481
Query: 1129 SLAFIFGGAIDNAVLRDKNGQSVGGQMVVALLSWPSPWVLLIGSFLSTFGAALQCLCSAP 1308
S +FG I+ VLRDK G +V G +VV LSWPSPWV++IGSF ST GA LQ L AP
Sbjct: 482 SNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAP 541
Query: 1309 RLLQAIAKDEVIPLLSPFKKVTANNEPFXXXXXXXXXXXXXXXMGSMDTIAAVVDFFFLM 1488
RLLQAIAKD +IP L F AN EP + S+D +A ++ FFLM
Sbjct: 542 RLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLM 601
Query: 1489 CYAFVNIICTLHSLLGAPNWRPRFKYYHWFLSLLGAVLCFFIMFSTHWDYAIVACLLCLV 1668
CY FVN+ C L +LL PNWRPRF+YYHW LS +G +C +MF + W YAIVA ++ +
Sbjct: 602 CYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGM 661
Query: 1669 IYKYVEWKGAKKEWGDGIRGLALTTAQYSLMKIEDKEPHPKNWRPQLLLLLSMQWSKEII 1848
IYKY+E++GA+KEWGDGIRGL+L+ A+++L+++E+ PH KNWRPQLL+LL + E +
Sbjct: 662 IYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLD---EDL 718
Query: 1849 DVRYLNLLNLASQLKAGKGLTVVTAFLQGD-PTSPDDKKKGEQVKARMDFDMNQVRLRGF 2025
V++ LL ASQLKAGKGLT+V + + G+ + D EQ + M +++GF
Sbjct: 719 HVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGDALAAEQTIKHL---MEAEKVKGF 775
Query: 2026 AKTLVHSEDQVRGSMSTLVQSVGLGGLKPNTMLISWPVHERE-EDMTEYNTFIEKVHAAS 2202
+ +V + +++ +S L+QS GLGG+K NT+++ WP R+ ED + TFI V +
Sbjct: 776 CQLVVAA--KLKEGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTT 833
Query: 2203 INDMAIVVAKGIIDFPSAVFRMS-GMIDVYWIVHDGGLCLLMGYLLKQHKVWRGCKLRVI 2379
+A++VAK + FPS V + S G IDV WIVHDGG+ +L+ +LLKQHKVWR C +R+
Sbjct: 834 AAHLALLVAKNVSFFPSNVEQFSEGNIDVRWIVHDGGMLMLLPFLLKQHKVWRKCSIRIF 893
Query: 2380 GIAQESDNNVKMQEDLQKYVYQLRIDAKIMIVELADPEISKNAFERTLLMEERTMMMRDL 2559
+AQ DN+++M++DL ++Y LRI+A++ +VE+ D +IS +ERTL+ME+R+ M+R
Sbjct: 894 TVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRH- 952
Query: 2560 QKVSGGGMSLSLPPANAPRAPSPLVTSERRANSKXXXXXXXXXXXXXXXXXXXXXXXXQA 2739
M LS + S R S A
Sbjct: 953 -------MRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMA 1005
Query: 2740 NQETKTKK-ERMKAL-----DRSKVSKMHTAVRLNELLLQHSANSQLILLNLPKPPVHKD 2901
++ K K E + L D+S V +MHTAV+LNE+++ S ++L+LLN+P PP ++
Sbjct: 1006 SRGQKVKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPP--RN 1063
Query: 2902 QQALDDYVHYLEVMTDKLNRVIFVRGTGKEVIT 3000
+ ++Y+ +LEV+T+ L RV+ VRG G EVIT
Sbjct: 1064 PEGDENYMEFLEVLTEGLERVLLVRGGGSEVIT 1096
>gi|50733496|ref|XP_418891.1| PREDICTED: similar to mFLJ00098 protein
[Gallus gallus]
Length = 1120
Score = 724 bits (1868), Expect = 0.0
Identities = 424/1065 (39%), Positives = 610/1065 (56%), Gaps = 66/1065 (6%)
Frame = +1
Query: 4 PFFSSYLK-----AHITPGPLERAQSSSHGGHGAKAD-LGVLLGVYLPTIQHILGVTMFI 165
P SS L ++T G +E K +G +GVYLP +Q+ILGV +F+
Sbjct: 77 PMVSSLLNKLANYTNVTQGVVEHEADEDSKRKEVKVPRMGTFIGVYLPCLQNILGVILFL 136
Query: 166 RLFWLVGIAGLGQXXXXXXXXXXXXXXXXISISAVATNGVVESGGAYFMISRNLGPEFGS 345
RL W+VG AG+ + IS+SA+ATNGVV +GG+Y+MISR+LGPEFG
Sbjct: 137 RLTWIVGTAGVLESFIIVFMCCACTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGG 196
Query: 346 AVGILFYLANTVATSMYLVGGVEILLLYIFPGLT-FGGVEGQHDTSMFGTMTNSLRFYST 522
AVG+ FYL T A +MY++G +EILL YI P F E +T M N++R Y T
Sbjct: 197 AVGLCFYLGTTFAGAMYILGTIEILLTYISPSAAIFKAEEVGEETE---AMLNNMRVYGT 253
Query: 523 ILLLIEFAIVAMGVKFVQMLAPVSLVCVILSILACYAGGVTKTIYPDSGQYVCMYNDRLL 702
++++ +V +GVK+V LA V L CVILSI+A YAG + I P +C+ +R L
Sbjct: 254 CIIILMAIVVFVGVKYVNKLALVFLACVILSIIAIYAGVIKTAIDPPDFP-ICLLGNRTL 312
Query: 703 QSSAVLNESIPLDEICNYCNINNTFLADRVCGGRCNSTTIP--------HVSPFRCINGF 858
+ D + NN + CNS+ +P ++ I G
Sbjct: 313 SKRS-------FDVCAKFTERNNETKTTNLWLLFCNSS-LPTAMCDDYFSLNNVTEIQGI 364
Query: 859 PGFQGGQTLLENLGPNYLEKGEAAHGTQADTKSD-----------VYQDVRTSFFVLLAI 1005
PG G L++NL Y EKG + S V+ D+ T F VL+ I
Sbjct: 365 PGILSG-VLIDNLWSTYSEKGSIVEKKNQPSVSGSEDIKIAGRPYVFTDIMTYFTVLVGI 423
Query: 1006 YFPAVTGIFTGANMSGDLKNPQASIPAGTIAANLTTSFVYFSLAFIFGGAIDNAVLRDKN 1185
YFP+VTGI G+N SGDLK+ Q SIP GTI A TTSF+Y S +FG I+ VLRDK
Sbjct: 424 YFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAISTTSFIYLSCIVLFGACIEGVVLRDKF 483
Query: 1186 GQSVGGQMVVALLSWPSPWVLLIGSFLSTFGAALQCLCSAPRLLQAIAKDEVIPLLSPFK 1365
G++V G +VV L+WPSPWV++IGSF ST GA LQ L APRLLQAIA+D ++P + F
Sbjct: 484 GEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIVPFIQVFG 543
Query: 1366 KVTANNEPFXXXXXXXXXXXXXXXMGSMDTIAAVVDFFFLMCYAFVNIICTLHSLLGAPN 1545
AN EP + S+D++A ++ FFLMCY FVN+ C + +LL PN
Sbjct: 544 HGKANGEPTWALLLTAAICEIGILIASLDSVAPILSMFFLMCYMFVNLACAVQTLLRTPN 603
Query: 1546 WRPRFKYYHWFLSLLGAVLCFFIMFSTHWDYAIVACLLCLVIYKYVEWKGAKKEWGDGIR 1725
WRPRFKYYHW LS LG LC +MF W YA++A L+ IYKY+E++GA+KEWGDGIR
Sbjct: 604 WRPRFKYYHWTLSFLGMSLCLALMFICSWYYALIAMLIAGCIYKYIEYRGAEKEWGDGIR 663
Query: 1726 GLALTTAQYSLMKIEDKEPHPKNWRPQLLLLLSMQWSKEIIDVRYLNLLNLASQLKAGKG 1905
GL+L A+Y+L+++ED PH KNWRPQLL+LL++ + V++ LL+ SQLKAGKG
Sbjct: 664 GLSLNAARYALLRVEDGPPHTKNWRPQLLVLLNLDCEQL---VKHPRLLSFTSQLKAGKG 720
Query: 1906 LTVVTAFLQGD--PTSPDDKKKGEQVKARMDFDMNQVRLRGFAKTLVHSEDQVRGSMSTL 2079
LT+V + LQG + +K E VKA M + + +GF + +V R +S L
Sbjct: 721 LTIVGSVLQGTYLDKCVETQKAEENVKALMAVE----KTKGFCQIVV--SPSFRDGISHL 774
Query: 2080 VQSVGLGGLKPNTMLISWPVH-EREEDMTEYNTFIEKVHAASINDMAIVVAKGIIDFPSA 2256
+QS GLGG+K NT+L++WP ++ E+ + F++ V + A++VAK I FP+
Sbjct: 775 IQSAGLGGMKHNTVLMAWPQSWKQTENHFSWKNFVDTVRETTAAQQALLVAKNIDLFPTN 834
Query: 2257 VFRMS-GMIDVYWIVHDGGLCLLMGYLLKQHKVWRGCKLRVIGIAQESDNNVKMQEDLQK 2433
R + G IDV+WIVHDGG+ +L+ +LL+QHKVWR CK+R+ +AQ DN+++M++DLQ
Sbjct: 835 QERFTEGNIDVWWIVHDGGMLMLLPFLLRQHKVWRKCKMRIFTVAQMDDNSIQMKKDLQM 894
Query: 2434 YVYQLRIDAKIMIVELADPEISKNAFERTLLMEERTMMMRDLQ----------------- 2562
++Y LR++A++ +VE+ + +IS +E+TL+ME+R+ M++ +Q
Sbjct: 895 FLYHLRLNAEVEVVEMFENDISAFTYEKTLMMEQRSQMLKQMQLSKNEREREIQSITDES 954
Query: 2563 KVSGGGMSLSLPPANAPRAPSPLVTSERRANSKXXXXXXXXXXXXXXXXXXXXXXXXQAN 2742
+ S S S P + + L + ++ +
Sbjct: 955 RGSVRRKSCSSPQSIGQDVQALLNNDYDKEEAQLIHDRNTASRSAPAVKASVAAAMPEKV 1014
Query: 2743 QETKTKK----ERMKALD---------------RSKVSKMHTAVRLNELLLQHSANSQLI 2865
Q T TK+ E+ K D +S V +MHTAV+LN ++L S ++QL+
Sbjct: 1015 QMTWTKEKFVAEKHKNKDTNVSGFKDIFNMKPNQSNVRRMHTAVKLNGVVLNKSQHAQLV 1074
Query: 2866 LLNLPKPPVHKDQQALDDYVHYLEVMTDKLNRVIFVRGTGKEVIT 3000
LLN+P PP K+++ ++Y+ +LEV+T+ L+RV+ VRG+G+EVIT
Sbjct: 1075 LLNMPGPP--KNRKGDENYMEFLEVLTEGLDRVLLVRGSGREVIT 1117
>gi|32490535|gb|AAP84988.1| potassium-chloride cotransporter isoform 4
[Oryctolagus cuniculus]
Length = 1106
Score = 722 bits (1864), Expect = 0.0
Identities = 412/1034 (39%), Positives = 599/1034 (57%), Gaps = 35/1034 (3%)
Frame = +1
Query: 4 PFFSSYLK-----AHITPGPLERAQSSSHGGHGAKAD-LGVLLGVYLPTIQHILGVTMFI 165
P SS L +++ G ++ ++ +KA +G +GVYLP +Q+ILGV +F+
Sbjct: 104 PMVSSLLNKLANYTNLSQGVVDHEEAEDSRPRESKAPCMGTFIGVYLPCLQNILGVILFL 163
Query: 166 RLFWLVGIAGLGQXXXXXXXXXXXXXXXXISISAVATNGVVESGGAYFMISRNLGPEFGS 345
RL W+VG AG+ + +S+SA+ATNGVV +GG+Y+MISR+LGPEFG
Sbjct: 164 RLTWIVGAAGVLESFLVVSMCCTCTMLTAVSMSAIATNGVVPAGGSYYMISRSLGPEFGG 223
Query: 346 AVGILFYLANTVATSMYLVGGVEILLLYIFPGLTFGGVEGQHDTSMFGTMTNSLRFYSTI 525
AVG+ FYL T A +MY++G +EI L YI PG E + + +++R Y +
Sbjct: 224 AVGLCFYLGTTFAGAMYILGTIEIFLTYISPGAAVFQAETPEGEA--AALLHNMRVYGSC 281
Query: 526 LLLIEFAIVAMGVKFVQMLAPVSLVCVILSILACYAGGVTKTIYPDSGQYVCMYNDRLLQ 705
L + +V +GVK+V LA V L CV+LSILA YAG V KT + VC+ +R L
Sbjct: 282 TLALMAVVVFVGVKYVNKLALVFLACVVLSILAIYAG-VIKTAFDPPDIPVCLLGNRTLA 340
Query: 706 SSAVLNESIPLDEICNYCNINNTFLADRVCGGRCNSTTIPHV-------SPFRCINGFPG 864
D ++N + G CN +++ + I G PG
Sbjct: 341 RRG-------FDTCAKVRAVSNGTATTALWGLFCNGSSLDTACNEYFAQNNVTEIQGIPG 393
Query: 865 FQGGQTLLENLGPNYLE-------KGEAAHGTQADTKSD----VYQDVRTSFFVLLAIYF 1011
G LL+NL Y + KG A+ T D ++ V D+ T F VL+ IYF
Sbjct: 394 VASG-VLLDNLWSAYSDRGAFVEKKGVASVPTPEDGRASGLPYVLSDITTYFTVLVGIYF 452
Query: 1012 PAVTGIFTGANMSGDLKNPQASIPAGTIAANLTTSFVYFSLAFIFGGAIDNAVLRDKNGQ 1191
P+VTGI G+N SGDLK+ Q SIP GTI A +TTSF+Y S +FG I+ VLRDK G+
Sbjct: 453 PSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGVVLRDKFGE 512
Query: 1192 SVGGQMVVALLSWPSPWVLLIGSFLSTFGAALQCLCSAPRLLQAIAKDEVIPLLSPFKKV 1371
++ G +V+ +L+WPSPWV++IGSF ST GA LQ L APRLLQAIA+D ++P L F
Sbjct: 513 ALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIVPFLQVFGHG 572
Query: 1372 TANNEPFXXXXXXXXXXXXXXXMGSMDTIAAVVDFFFLMCYAFVNIICTLHSLLGAPNWR 1551
AN EP + S+D++A ++ FFLMCY FVN+ C + +LL PNWR
Sbjct: 573 KANGEPTWALLLTALICETGILIASLDSVAPILSMFFLMCYMFVNLACAVQTLLRTPNWR 632
Query: 1552 PRFKYYHWFLSLLGAVLCFFIMFSTHWDYAIVACLLCLVIYKYVEWKGAKKEWGDGIRGL 1731
PRFKYYHW LS LG LC +MF W YA+ A L+ IYKY+E++GA+KEWGDGIRGL
Sbjct: 633 PRFKYYHWTLSFLGMSLCLALMFICSWYYALFAMLIAGCIYKYIEYRGAEKEWGDGIRGL 692
Query: 1732 ALTTAQYSLMKIEDKEPHPKNWRPQLLLLLSMQWSKEIIDVRYLNLLNLASQLKAGKGLT 1911
+L A+Y+L+++E PH KNWRPQ+L++L++ + + R LL+ SQLKAGKGLT
Sbjct: 693 SLNAARYALLRVEHGPPHTKNWRPQVLVMLTLDAEQRVTHPR---LLSFTSQLKAGKGLT 749
Query: 1912 VVTAFLQGDPTSPDDKKKGEQVKARMDFDMNQVRLRGFAKTLVHSEDQVRGSMSTLVQSV 2091
+V + L+G T D + ++ + + M +++GF + +V S +R S L+Q+
Sbjct: 750 IVGSVLEG--TFLDKHVEAQRAEENIRALMGAEKMKGFCQLVVSS--SLRDGCSHLIQAA 805
Query: 2092 GLGGLKPNTMLISWPVHEREEDMT-EYNTFIEKVHAASINDMAIVVAKGIIDFPSAVFRM 2268
GLGG+K NT+L++WP ++ D + F++ V + A++VAK I FP R
Sbjct: 806 GLGGMKHNTVLMAWPEAWKQPDSPYSWKYFVDTVRDTTAAQQALLVAKNIDAFPQNQERF 865
Query: 2269 S-GMIDVYWIVHDGGLCLLMGYLLKQHKVWRGCKLRVIGIAQESDNNVKMQEDLQKYVYQ 2445
S G IDV+W+VHDGG+ +L+ +LL+QHKVWR C++R+ +AQ DN+V+M++DLQ ++Y
Sbjct: 866 SEGSIDVWWVVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSVQMKKDLQMFLYH 925
Query: 2446 LRIDAKIMIVELADPEISKNAFERTLLMEERTMMMRDLQKVSGGGMSLSLPPANAPRAPS 2625
LRI A++ +VE+ + +IS +E+TLLME+R+ M++ +Q G R
Sbjct: 926 LRISAEVEVVEMVENDISAFTYEKTLLMEQRSQMLKQMQLTKG------------ERERE 973
Query: 2626 PLVTSERRANSKXXXXXXXXXXXXXXXXXXXXXXXXQANQETKTKKERMKA--------- 2778
+ +R N+ + E K+ A
Sbjct: 974 AQLIHDR--NTASHTAASRAQAPPTPDKVQMTWTKEKLTAEKHRNKDAGAAGFRDLFSLK 1031
Query: 2779 LDRSKVSKMHTAVRLNELLLQHSANSQLILLNLPKPPVHKDQQALDDYVHYLEVMTDKLN 2958
D S V +MHTAV+LN ++L S ++QL+LLN+P PP K++Q ++Y+ +LEV+T+ LN
Sbjct: 1032 PDHSNVRRMHTAVKLNGVVLSRSQDAQLVLLNMPGPP--KNRQGDENYMEFLEVLTEGLN 1089
Query: 2959 RVIFVRGTGKEVIT 3000
RV+ VRG G+EVIT
Sbjct: 1090 RVVLVRGGGREVIT 1103
>gi|34856648|ref|XP_342490.1| similar to K-Cl cotransporter 3b [Rattus
norvegicus]
Length = 1094
Score = 719 bits (1857), Expect = 0.0
Identities = 417/1003 (41%), Positives = 588/1003 (58%), Gaps = 36/1003 (3%)
Frame = +1
Query: 100 LGVLLGVYLPTIQHILGVTMFIRLFWLVGIAGLGQXXXXXXXXXXXXXXXXISISAVATN 279
+G +GVYLP +Q+I GV +F+RL W+VG AG+ Q IS+SA+ATN
Sbjct: 119 MGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATN 178
Query: 280 GVVESGGAYFMISRNLGPEFGSAVGILFYLANTVATSMYLVGGVEILLLYIFPGLTFGGV 459
GVV +GG+YFMISR LGPEFG AVG+ FYL T A +MY++G +EI L+YI P
Sbjct: 179 GVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFRS 238
Query: 460 EGQHDTSMFGTMTNSLRFYSTILLLIEFAIVAMGVKFVQMLAPVSLVCVILSILACYAGG 639
+ S M N++R Y T L++ +V +GV++V A + L CVI+SILA YAG
Sbjct: 239 DDALKES--AAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGA 296
Query: 640 VTKTIYPDSGQYVCMYNDRLLQSSAVLNESIPLDEICNYCN-INNTFLADRVCGGRCNST 816
+ + P VCM +R L S + +IC+ +NN + ++ G CNS+
Sbjct: 297 IKSSFAPPHFP-VCMLGNRTLSSRHL--------DICSKTKEVNNMTIPSKLWGFFCNSS 347
Query: 817 TIPHVS--------PFRCINGFPGFQGGQTLLENLGPNYLEKGEAAHGTQADTKSD---- 960
+ + I G PG G + ENL NYL KGE A +
Sbjct: 348 QFFNATCDEYFVHNNVTSIQGIPGLASG-IITENLWSNYLPKGEIIEKPSAKSSDVLGNL 406
Query: 961 ----VYQDVRTSFFVLLAIYFPAVTGIFTGANMSGDLKNPQASIPAGTIAANLTTSFVYF 1128
V D+ TSF +L+ I+FP+VTGI G+N SGDLK+ Q SIP GTI A LTTSF
Sbjct: 407 NHEYVLADITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFTTI 466
Query: 1129 ----------SLAFIFGGAIDNAVLRDKNGQSVGGQMVVALLSWPSPWVLLIGSFLSTFG 1278
S +FG I+ VLRDK G +V G +VV LSWPSPWV++IGSF ST G
Sbjct: 467 ISLTLSITDLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCG 526
Query: 1279 AALQCLCSAPRLLQAIAKDEVIPLLSPFKKVTANNEPFXXXXXXXXXXXXXXXMGSMDTI 1458
A LQ L APRLLQAIAKD +IP L F AN EP + S+D +
Sbjct: 527 AGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLV 586
Query: 1459 AAVVDFFFLMCYAFVNIICTLHSLLGAPNWRPRFKYYHWFLSLLGAVLCFFIMFSTHWDY 1638
A ++ FFLMCY FVN+ C L +LL P+WRPRF+YYHW LS +G +C +MF + W Y
Sbjct: 587 APILSMFFLMCYLFVNLACALQTLLRTPHWRPRFRYYHWALSFMGMSICLALMFISSWYY 646
Query: 1639 AIVACLLCLVIYKYVEWKGAKKEWGDGIRGLALTTAQYSLMKIEDKEPHPKNWRPQLLLL 1818
AIVA ++ +IYKY+E++GA+KEWGDGIRGL+L+ A+++L+++E+ PH KNWRPQLL+L
Sbjct: 647 AIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVL 706
Query: 1819 LSMQWSKEIIDVRYLNLLNLASQLKAGKGLTVVTAFLQGD-PTSPDDKKKGEQVKARMDF 1995
L + E + V++ LL ASQLKAGKGLT+V + + G+ + D EQ +
Sbjct: 707 LKLD---EDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGDALAAEQTIKHL-- 761
Query: 1996 DMNQVRLRGFAKTLVHSEDQVRGSMSTLVQSVGLGGLKPNTMLISWPVHERE-EDMTEYN 2172
M +++GF + +V + +++ +S L+QS GLGG+K NT+++ WP R+ ED +
Sbjct: 762 -MEAEKVKGFCQLVVAA--KLKEGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWK 818
Query: 2173 TFIEKVHAASINDMAIVVAKGIIDFPSAVFRMS-GMIDVYWIVHDGGLCLLMGYLLKQHK 2349
TFI V + +A++VAK + FPS V + S G IDV+WIVHDGG+ +L+ +LLKQHK
Sbjct: 819 TFIGTVRVTTAAHLALLVAKNVSFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHK 878
Query: 2350 VWRGCKLRVIGIAQESDNNVKMQEDLQKYVYQLRIDAKIMIVELADPEISKNAFERTLLM 2529
VWR C +R+ +AQ DN+++M++DL ++Y LRI+A++ +VE+ D +IS +ERTL+M
Sbjct: 879 VWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMM 938
Query: 2530 EERTMMMRDLQKVSGGGMSLSLPPANAPRAPSPLVTSERRANSKXXXXXXXXXXXXXXXX 2709
E+R+ M+R M LS + S R S
Sbjct: 939 EQRSQMLRH--------MRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVH 990
Query: 2710 XXXXXXXXQANQETKTKK-ERMKAL-----DRSKVSKMHTAVRLNELLLQHSANSQLILL 2871
A++ K K E + L D+S V +MHTAV+LNE+++ S ++L+LL
Sbjct: 991 MTWTKDKYMASRGQKVKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLL 1050
Query: 2872 NLPKPPVHKDQQALDDYVHYLEVMTDKLNRVIFVRGTGKEVIT 3000
N+P PP ++ + ++Y+ +LEV+T+ L RV+ VRG G EVIT
Sbjct: 1051 NMPGPP--RNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVIT 1091
>gi|3015641|gb|AAC39685.1| erythroid K:Cl cotransporter splicing
isoform 2 [Homo sapiens]
Length = 1068
Score = 716 bits (1848), Expect = 0.0
Identities = 411/988 (41%), Positives = 579/988 (58%), Gaps = 35/988 (3%)
Frame = +1
Query: 31 HITPGPLERAQSSSHGGHGAKA----DLGVLLGVYLPTIQHILGVTMFIRLFWLVGIAGL 198
++T G E ++ S G +A +G L+GVYLP +Q+I GV +F+RL W+VG AG+
Sbjct: 91 NLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGV 150
Query: 199 GQXXXXXXXXXXXXXXXXISISAVATNGVVESGGAYFMISRNLGPEFGSAVGILFYLANT 378
Q IS+SA+ATNGVV +GG+YFMISR+LGPEFG AVG+ FYL T
Sbjct: 151 LQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTT 210
Query: 379 VATSMYLVGGVEILLLYIFPGLTFGGVEGQHDTSMFGTMTNSLRFYSTILLLIEFAIVAM 558
A +MY++G +EILL YI P G HDTS N++R Y TI L +V +
Sbjct: 211 FAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTS--NATLNNMRVYGTIFLTFMTLVVFV 268
Query: 559 GVKFVQMLAPVSLVCVILSILACYAGGVTKTIYPDSGQYVCMYNDRLLQSSAVLNESIPL 738
GVK+V A + L CVI+SIL+ YAGG+ K+I+ VCM +R L
Sbjct: 269 GVKYVNKFASLFLACVIISILSIYAGGI-KSIFDPPVFPVCMLGNRTLSRDQ-------F 320
Query: 739 DEICNYCNINNTFLADRVCGGRCNST--TIPHVSPFRCIN------GFPGFQGGQTLLEN 894
D ++N +A ++ C+S T P+ +N G PG G L EN
Sbjct: 321 DICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAG-VLQEN 379
Query: 895 LGPNYLEKGEAA--HGT-QADTKS-------DVYQDVRTSFFVLLAIYFPAVTGIFTGAN 1044
L YLEKG+ HG AD S V D+ TSF VL+ I+FP+VTGI G+N
Sbjct: 380 LWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGSN 439
Query: 1045 MSGDLKNPQASIPAGTIAANLTTSFVYFSLAFIFGGAIDNAVLRDKNGQSVGGQMVVALL 1224
SGDL++ Q SIP GTI A +TTS VYFS +FG I+ VLRDK G V +VV L
Sbjct: 440 RSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTL 499
Query: 1225 SWPSPWVLLIGSFLSTFGAALQCLCSAPRLLQAIAKDEVIPLLSPFKKVTANNEPFXXXX 1404
+WPSPWV++IGSF ST GA LQ L APRLLQAIAKD +IP L F N EP
Sbjct: 500 AWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALL 559
Query: 1405 XXXXXXXXXXXMGSMDTIAAVVDFFFLMCYAFVNIICTLHSLLGAPNWRPRFKYYHWFLS 1584
+ S+D +A ++ FFLMCY FVN+ C + +LL PNWRPRFKYYHW LS
Sbjct: 560 LTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALS 619
Query: 1585 LLGAVLCFFIMFSTHWDYAIVACLLCLVIYKYVEWKGAKKEWGDGIRGLALTTAQYSLMK 1764
LG LC +MF + W YA+VA L+ +IYKY+E++GA+KEWGDGIRGL+L+ A+Y+L++
Sbjct: 620 FLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLR 679
Query: 1765 IEDKEPHPKNWRPQLLLLLSMQWSKEIIDVRYLNLLNLASQLKAGKGLTVVTAFLQGD-P 1941
+E+ PH KNWRPQLL+LL + E + V+Y LL ASQLKAGKGLT+V + +QG
Sbjct: 680 LEEGPPHTKNWRPQLLVLLKLD---EDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFL 736
Query: 1942 TSPDDKKKGEQVKARMDFDMNQVRLRGFAKTLVHSEDQVRGSMSTLVQSVGLGGLKPNTM 2121
S + + EQ M M +++GF + +V S +VR ++ L+QS GLGG++ N++
Sbjct: 737 ESYGEAQAAEQTIKNM---MEIEKVKGFCQVVVAS--KVREGLAHLIQSCGLGGMRHNSV 791
Query: 2122 LISWPVHERE-EDMTEYNTFIEKVHAASINDMAIVVAKGIIDFPSAVFR-MSGMIDVYWI 2295
++ WP R+ ED + TFI+ V + +A++V K I +PS R + G IDV+WI
Sbjct: 792 VLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWI 851
Query: 2296 VHDGGLCLLMGYLLKQHKVWRGCKLRVIGIAQESDNNVKMQEDLQKYVYQLRIDAKIMIV 2475
VHDGG+ +L+ +LL+QHKVWR C++R+ +AQ DN+++M++DL ++Y LR++A++ +V
Sbjct: 852 VHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEVV 911
Query: 2476 ELADPEISKNAFERTLLMEERTMMMRDLQKVSGGGMSLSLPPANAPRAPSPLVTSERRAN 2655
E+ + +IS +ERTL+ME+R+ M+R ++ R + +R +
Sbjct: 912 EMHNSDISAYTYERTLMMEQRSQMLRQMRL------------TKTEREREAQLVKDRHSA 959
Query: 2656 SKXXXXXXXXXXXXXXXXXXXXXXXXQANQETKT-----KKERMKAL-----DRSKVSKM 2805
+ + T+T + + L D+S V +M
Sbjct: 960 LRLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRM 1019
Query: 2806 HTAVRLNELLLQHSANSQLILLNLPKPP 2889
HTAV+LNE+++ S +++L+LLN+P PP
Sbjct: 1020 HTAVKLNEVIVTRSHDARLVLLNMPGPP 1047
>gi|47847414|dbj|BAD21379.1| mFLJ00098 protein [Mus musculus]
Length = 1091
Score = 714 bits (1844), Expect = 0.0
Identities = 412/1028 (40%), Positives = 594/1028 (57%), Gaps = 29/1028 (2%)
Frame = +1
Query: 4 PFFSSYLK-----AHITPGPLERAQSSSHGGHGAKAD-LGVLLGVYLPTIQHILGVTMFI 165
P SS L +++ G +E + KA +G +GVYLP +Q+ILGV +F+
Sbjct: 88 PMVSSLLNKLANYTNLSQGVVEHEEDEDSRRREVKAPRMGTFIGVYLPCLQNILGVILFL 147
Query: 166 RLFWLVGIAGLGQXXXXXXXXXXXXXXXXISISAVATNGVVESGGAYFMISRNLGPEFGS 345
RL W+VG AG+ + IS+SA+ATNGVV +GG+Y+MISR+LGPEFG
Sbjct: 148 RLTWIVGAAGVMESFLIVAMCCTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGG 207
Query: 346 AVGILFYLANTVATSMYLVGGVEILLLYIFPGLTFGGVEGQHDTSMFGTMTNSLRFYSTI 525
AVG+ FYL T A +MY++G +EI L YI P E + + N++R Y +
Sbjct: 208 AVGLCFYLGTTFAGAMYILGTIEIFLTYISPSAAIFQAETADGEA--AALLNNMRVYGSC 265
Query: 526 LLLIEFAIVAMGVKFVQMLAPVSLVCVILSILACYAGGVTKTIYPDSGQYVCMYNDRLLQ 705
L + +V +GVK+V LA V L CV+LSILA YAG V KT + VC+ +R L
Sbjct: 266 ALALMAVVVFVGVKYVNKLALVFLACVVLSILAIYAG-VIKTAFAPPDIPVCLLGNRTL- 323
Query: 706 SSAVLNESIPLDEICNYCNINNTFLADRVCGGRCNSTTIPHV---SPFRCINGFPGFQGG 876
++ + + + N T L C G T + I G PG G
Sbjct: 324 ANRNFDTCAKMQVVSN--GTVTTALWRLFCNGSSLGATCDEYFAQNNVTEIQGIPGVASG 381
Query: 877 QTLLENLGPNYLEKGEAAH--GTQADTKSD---------VYQDVRTSFFVLLAIYFPAVT 1023
L+NL Y +KG G + S+ V D+ T F +L+ IYFP+VT
Sbjct: 382 -VFLDNLWSTYSDKGAFVEKKGVSSVPVSEESRPGGLPYVLTDIMTYFTMLVGIYFPSVT 440
Query: 1024 GIFTGANMSGDLKNPQASIPAGTIAANLTTSFVYFSLAFIFGGAIDNAVLRDKNGQSVGG 1203
GI G+N SGDLK+ Q SIP GTI A +TTSF+Y S +FG I+ VLRDK G+++ G
Sbjct: 441 GIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGVVLRDKFGEALQG 500
Query: 1204 QMVVALLSWPSPWVLLIGSFLSTFGAALQCLCSAPRLLQAIAKDEVIPLLSPFKKVTANN 1383
+V+ +L+WPSPWV++IGSF ST GA LQ L APRLLQAIA+D +IP L F AN
Sbjct: 501 NLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIIPFLQVFGHGKANG 560
Query: 1384 EPFXXXXXXXXXXXXXXXMGSMDTIAAVVDFFFLMCYAFVNIICTLHSLLGAPNWRPRFK 1563
EP + S+D++A ++ FFLMCY FVN+ C + +LL PNWRPRFK
Sbjct: 561 EPTWALLLTALICETGILIASLDSVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFK 620
Query: 1564 YYHWFLSLLGAVLCFFIMFSTHWDYAIVACLLCLVIYKYVEWKGAKKEWGDGIRGLALTT 1743
+YHW LS LG LC +MF W YA+ A L+ IYKY+E++GA+KEWGDGIRGL+L
Sbjct: 621 FYHWTLSFLGMSLCLALMFICSWYYALFAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNA 680
Query: 1744 AQYSLMKIEDKEPHPKNWRPQLLLLLSMQWSKEIIDVRYLNLLNLASQLKAGKGLTVVTA 1923
A+Y+L+++E PH KNWRPQ+L++L++ + V++ LL+ SQLKAGKGLT+V +
Sbjct: 681 ARYALLRVEHGPPHTKNWRPQVLVMLNLDSEQ---CVKHPRLLSFTSQLKAGKGLTIVGS 737
Query: 1924 FLQGDPTSPDDKKKGEQVKARMDFDMNQVRLRGFAKTLVHSEDQVRGSMSTLVQSVGLGG 2103
L+G T D + ++ + + M+ + +GF + +V S +R S L+QS GLGG
Sbjct: 738 VLEG--TYLDKHVEAQRAEENIRSLMSAEKTKGFCQLVVSS--NLRDGASHLIQSAGLGG 793
Query: 2104 LKPNTMLISWPVHEREEDMT-EYNTFIEKVHAASINDMAIVVAKGIIDFPSAVFRMS-GM 2277
+K NT+L++WP +E D + F++ V + A++VAK I FP R S G
Sbjct: 794 MKHNTVLMAWPEAWKEADNPFSWKNFVDTVRDTTAAHQALLVAKNIDLFPQNQERFSDGN 853
Query: 2278 IDVYWIVHDGGLCLLMGYLLKQHKVWRGCKLRVIGIAQESDNNVKMQEDLQKYVYQLRID 2457
IDV+WIVHDGG+ +L+ +LL+QHKVWR C++R+ +AQ DN+++M++DLQ ++Y LRI
Sbjct: 854 IDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQMFLYHLRIS 913
Query: 2458 AKIMIVELADPEISKNAFERTLLMEERTMMMRDLQKVSGGGMSLSLPPANAPRAPSPLVT 2637
A++ +VE+ + +IS +E+TL+ME+R+ M++ +Q N + L+
Sbjct: 914 AEVEVVEMVENDISAFTYEKTLMMEQRSQMLKQMQL-----------SKNEREREAQLIH 962
Query: 2638 SERRANSKXXXXXXXX--XXXXXXXXXXXXXXXXQANQETKTKKERMKAL-----DRSKV 2796
A+ + ++ T K L D+S V
Sbjct: 963 DRNTASHTTATARTQAPPTPDKVQMTWTKEKLIAEKHRNKDTGPSGFKDLFSLKPDQSNV 1022
Query: 2797 SKMHTAVRLNELLLQHSANSQLILLNLPKPPVHKDQQALDDYVHYLEVMTDKLNRVIFVR 2976
+MHTAV+LN ++L S ++QL+LLN+P PP K +Q ++Y+ +LEV+T+ LNRV+ VR
Sbjct: 1023 RRMHTAVKLNGVVLNKSQDAQLVLLNMPGPP--KSRQGDENYMEFLEVLTEGLNRVLLVR 1080
Query: 2977 GTGKEVIT 3000
G G+EVIT
Sbjct: 1081 GGGREVIT 1088
>gi|6755534|ref|NP_035520.1| solute carrier family 12, member 7 [Mus
musculus]
gi|27151692|sp|Q9WVL3|S127_MOUSE Solute carrier family 12 member 7
(Electroneutral potassium-chloride cotransporter 4) (K-Cl
cotransporter 4)
gi|5051640|gb|AAD38328.1| putative potassium-chloride
cotransporter-4; KCC4 [Mus musculus]
Length = 1083
Score = 714 bits (1844), Expect = 0.0
Identities = 412/1028 (40%), Positives = 594/1028 (57%), Gaps = 29/1028 (2%)
Frame = +1
Query: 4 PFFSSYLK-----AHITPGPLERAQSSSHGGHGAKAD-LGVLLGVYLPTIQHILGVTMFI 165
P SS L +++ G +E + KA +G +GVYLP +Q+ILGV +F+
Sbjct: 80 PMVSSLLNKLANYTNLSQGVVEHEEDEDSRRREVKAPRMGTFIGVYLPCLQNILGVILFL 139
Query: 166 RLFWLVGIAGLGQXXXXXXXXXXXXXXXXISISAVATNGVVESGGAYFMISRNLGPEFGS 345
RL W+VG AG+ + IS+SA+ATNGVV +GG+Y+MISR+LGPEFG
Sbjct: 140 RLTWIVGAAGVMESFLIVAMCCTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGG 199
Query: 346 AVGILFYLANTVATSMYLVGGVEILLLYIFPGLTFGGVEGQHDTSMFGTMTNSLRFYSTI 525
AVG+ FYL T A +MY++G +EI L YI P E + + N++R Y +
Sbjct: 200 AVGLCFYLGTTFAGAMYILGTIEIFLTYISPSAAIFQAETADGEA--AALLNNMRVYGSC 257
Query: 526 LLLIEFAIVAMGVKFVQMLAPVSLVCVILSILACYAGGVTKTIYPDSGQYVCMYNDRLLQ 705
L + +V +GVK+V LA V L CV+LSILA YAG V KT + VC+ +R L
Sbjct: 258 ALALMAVVVFVGVKYVNKLALVFLACVVLSILAIYAG-VIKTAFAPPDIPVCLLGNRTL- 315
Query: 706 SSAVLNESIPLDEICNYCNINNTFLADRVCGGRCNSTTIPHV---SPFRCINGFPGFQGG 876
++ + + + N T L C G T + I G PG G
Sbjct: 316 ANRNFDTCAKMQVVSN--GTVTTALWRLFCNGSSLGATCDEYFAQNNVTEIQGIPGVASG 373
Query: 877 QTLLENLGPNYLEKGEAAH--GTQADTKSD---------VYQDVRTSFFVLLAIYFPAVT 1023
L+NL Y +KG G + S+ V D+ T F +L+ IYFP+VT
Sbjct: 374 -VFLDNLWSTYSDKGAFVEKKGVSSVPVSEESRPGGLPYVLTDIMTYFTMLVGIYFPSVT 432
Query: 1024 GIFTGANMSGDLKNPQASIPAGTIAANLTTSFVYFSLAFIFGGAIDNAVLRDKNGQSVGG 1203
GI G+N SGDLK+ Q SIP GTI A +TTSF+Y S +FG I+ VLRDK G+++ G
Sbjct: 433 GIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGVVLRDKFGEALQG 492
Query: 1204 QMVVALLSWPSPWVLLIGSFLSTFGAALQCLCSAPRLLQAIAKDEVIPLLSPFKKVTANN 1383
+V+ +L+WPSPWV++IGSF ST GA LQ L APRLLQAIA+D +IP L F AN
Sbjct: 493 NLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIIPFLQVFGHGKANG 552
Query: 1384 EPFXXXXXXXXXXXXXXXMGSMDTIAAVVDFFFLMCYAFVNIICTLHSLLGAPNWRPRFK 1563
EP + S+D++A ++ FFLMCY FVN+ C + +LL PNWRPRFK
Sbjct: 553 EPTWALLLTALICETGILIASLDSVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFK 612
Query: 1564 YYHWFLSLLGAVLCFFIMFSTHWDYAIVACLLCLVIYKYVEWKGAKKEWGDGIRGLALTT 1743
+YHW LS LG LC +MF W YA+ A L+ IYKY+E++GA+KEWGDGIRGL+L
Sbjct: 613 FYHWTLSFLGMSLCLALMFICSWYYALFAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNA 672
Query: 1744 AQYSLMKIEDKEPHPKNWRPQLLLLLSMQWSKEIIDVRYLNLLNLASQLKAGKGLTVVTA 1923
A+Y+L+++E PH KNWRPQ+L++L++ + V++ LL+ SQLKAGKGLT+V +
Sbjct: 673 ARYALLRVEHGPPHTKNWRPQVLVMLNLDSEQ---CVKHPRLLSFTSQLKAGKGLTIVGS 729
Query: 1924 FLQGDPTSPDDKKKGEQVKARMDFDMNQVRLRGFAKTLVHSEDQVRGSMSTLVQSVGLGG 2103
L+G T D + ++ + + M+ + +GF + +V S +R S L+QS GLGG
Sbjct: 730 VLEG--TYLDKHVEAQRAEENIRSLMSAEKTKGFCQLVVSS--NLRDGASHLIQSAGLGG 785
Query: 2104 LKPNTMLISWPVHEREEDMT-EYNTFIEKVHAASINDMAIVVAKGIIDFPSAVFRMS-GM 2277
+K NT+L++WP +E D + F++ V + A++VAK I FP R S G
Sbjct: 786 MKHNTVLMAWPEAWKEADNPFSWKNFVDTVRDTTAAHQALLVAKNIDLFPQNQERFSDGN 845
Query: 2278 IDVYWIVHDGGLCLLMGYLLKQHKVWRGCKLRVIGIAQESDNNVKMQEDLQKYVYQLRID 2457
IDV+WIVHDGG+ +L+ +LL+QHKVWR C++R+ +AQ DN+++M++DLQ ++Y LRI
Sbjct: 846 IDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQMFLYHLRIS 905
Query: 2458 AKIMIVELADPEISKNAFERTLLMEERTMMMRDLQKVSGGGMSLSLPPANAPRAPSPLVT 2637
A++ +VE+ + +IS +E+TL+ME+R+ M++ +Q N + L+
Sbjct: 906 AEVEVVEMVENDISAFTYEKTLMMEQRSQMLKQMQL-----------SKNEREREAQLIH 954
Query: 2638 SERRANSKXXXXXXXX--XXXXXXXXXXXXXXXXQANQETKTKKERMKAL-----DRSKV 2796
A+ + ++ T K L D+S V
Sbjct: 955 DRNTASHTTATARTQAPPTPDKVQMTWTKEKLIAEKHRNKDTGPSGFKDLFSLKPDQSNV 1014
Query: 2797 SKMHTAVRLNELLLQHSANSQLILLNLPKPPVHKDQQALDDYVHYLEVMTDKLNRVIFVR 2976
+MHTAV+LN ++L S ++QL+LLN+P PP K +Q ++Y+ +LEV+T+ LNRV+ VR
Sbjct: 1015 RRMHTAVKLNGVVLNKSQDAQLVLLNMPGPP--KSRQGDENYMEFLEVLTEGLNRVLLVR 1072
Query: 2977 GTGKEVIT 3000
G G+EVIT
Sbjct: 1073 GGGREVIT 1080
>gi|47213488|emb|CAF91145.1| unnamed protein product [Tetraodon
nigroviridis]
Length = 1211
Score = 714 bits (1843), Expect = 0.0
Identities = 424/1079 (39%), Positives = 596/1079 (54%), Gaps = 89/1079 (8%)
Frame = +1
Query: 31 HITPGPLERAQSSSHGGH---GAKADLGVLLGVYLPTIQHILGVTMFIRLFWLVGIAGLG 201
++T G E ++ S G +G +GVYLP +Q+I GV +F+RL W+VG AG+
Sbjct: 145 NLTQGAKEHEEAESIGEKKKPSKSPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGNAGVL 204
Query: 202 QXXXXXXXXXXXXXXXXISISAVATNGVVESGGAYFMISRNLGPEFGSAVGILFYLANTV 381
Q IS+SA+ATNGVV +GG+YFMISR+LGPEFG AVG+ FYL T
Sbjct: 205 QGLCIVFICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTF 264
Query: 382 ATSMYLVGGVEILLLYIFPGLTFGGVEGQHDTSMFGTMTNSLRFYSTILLLIEFAIVAMG 561
A +MY++G +EILL+YI P E +H M N++R Y +I LL+ +V +G
Sbjct: 265 AGAMYILGAIEILLMYIAPKAAI--FEPKHPEGEGAAMLNNMRVYGSICLLLMSLLVFVG 322
Query: 562 VKFVQMLAPVSLVCVILSILACYAGGVTKTIYPDSGQYVCMYNDRLLQSSAVLNESI--P 735
VK+V LA + L CVI+SI++ YAG + P VCM +R + + +
Sbjct: 323 VKYVNKLASIFLACVIISIVSIYAGALVSAFKPPHFP-VCMLGNRTISGHEIDDNQCAKT 381
Query: 736 LDEICNYCNINNTFLADRVCGGRCNSTTIP--------HVSPFRC--------------- 846
L E + N T L D G ++P + F C
Sbjct: 382 LVESAERADANFTALLDNSTLGPTFDPSLPPPVVEKTTSIWKFFCNGPELNASCDRYFSS 441
Query: 847 -----INGFPGFQGGQTLLENLGPNYLEKGEAAHGTQADTKSD----------VYQDVRT 981
I G PG + ENL +YL KGE + V+ D+ T
Sbjct: 442 NNFSEIQGIPGL-ASSIISENLWSSYLSKGEVVEKGSIQASDEAPPASTHHPYVFADITT 500
Query: 982 SFFVLLAIYFPAVTGIFTGANMSGDLKNPQASIPAGTIAANLTTSFVYFSLAFIFGGAID 1161
SF +L+ I+FP+VTGI G+N SGDLK+ Q SIP GTI A LTTS VY S +FG ID
Sbjct: 501 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQRSIPIGTILAILTTSIVYLSSVVLFGACID 560
Query: 1162 NAVLRDKNGQSVGGQMVVALLSWPSPWVLLIGSFLSTFGAALQCLCSAPRLLQAIAKDEV 1341
VLRDK G SV G +VV L+WPSPWV+++GSF ST GA LQ L APRLLQAIAKD V
Sbjct: 561 GVVLRDKFGDSVKGNLVVGTLAWPSPWVIVVGSFFSTCGAGLQSLTGAPRLLQAIAKDNV 620
Query: 1342 IPLLSPFKKVTANNEPFXXXXXXXXXXXXXXXMGSMDTIAAVVDFFFLMCYAFVNIICTL 1521
IP L F AN EP + S+D +A ++ FFLMCY FVN+ C L
Sbjct: 621 IPFLRVFGHGKANGEPTWALLLTALIAELGILIASLDLVAPILTMFFLMCYLFVNLACAL 680
Query: 1522 HSLLGAPNWRPRFKYYHWFLSLLGAVLCFFIMFSTHWDYAIVACLLCLVIYKYVEWKGAK 1701
+LL PNWRPRF YYHW LS LG ++C +MF + W YAIVA ++ +IYKY+E+ GA+
Sbjct: 681 QTLLRTPNWRPRFSYYHWTLSFLGMMICLALMFVSSWYYAIVAMVIAGMIYKYIEYHGAE 740
Query: 1702 KEWGDGIRGLALTTAQYSLMKIEDKEPHPKNWRPQLLLLLSMQWSKEIIDVRYLNLLNLA 1881
KEWGDGIRGL+L+ A+Y+L+++E+ PH KNWRPQLL+LL + E V+ LL A
Sbjct: 741 KEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLD---EDAHVKSPRLLTFA 797
Query: 1882 SQLKAGKGLTVVTAFLQGDPTSPDDKKKGEQVKARMDFD--MNQVRLRGFAKTLVHSEDQ 2055
SQLKAGKGLT+V + G+ + GE + A M++ R++GF + +V +
Sbjct: 798 SQLKAGKGLTIVGTVVSGNFL----QSYGEALAAEQTLKHLMDKERVKGFCQCIV--AQK 851
Query: 2056 VRGSMSTLVQSVGLGGLKPNTMLISWP-VHEREEDMTEYNTFIEKVHAASINDMAIVVAK 2232
R +S ++QS GLGG+KPNT+++ WP + ED + TFI V + +A++V K
Sbjct: 852 PREGISHMIQSSGLGGMKPNTVVMGWPHAWRQSEDPQSWKTFINTVRVTTTAHLALLVPK 911
Query: 2233 GIIDFPS-AVFRMSGMIDVYWIVHDGGLCLLMGYLLKQHK------------VWRGCKLR 2373
I FPS + G IDV+WIVHDGG+ +L+ +LL+QHK VWR C +R
Sbjct: 912 NISLFPSNSEPYTEGYIDVWWIVHDGGMLMLLPFLLRQHKAGATVSLSFLSNVWRKCGMR 971
Query: 2374 VIGIAQESDNNVKMQEDLQKYVYQLRIDAKIMIVELADPEISKNAFERTLLMEERTMMMR 2553
+ +AQ DN+++M++DL ++Y LRI+A++ +VE+ D +IS +ERTL+ME+R+ M+R
Sbjct: 972 IFTVAQMEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLR 1031
Query: 2554 -------DLQKVSGGGMSLSLPPANAPRAPSPLVTSERRANSKXXXXXXXXXXXXXXXXX 2712
D ++ S S A + +R + +
Sbjct: 1032 QMRLSKSDREREGNPCSSSSRQEAGGAARSQAQLVKDRNSMLRLTSIGSDDDDETDGERE 1091
Query: 2713 XXXXXXXQANQE-----TKTKKERMKAL------------------DRSKVSKMHTAVRL 2823
+ ++ TK K + KA D S V +MHTAV+L
Sbjct: 1092 RPSGGSTEHHRRVQMTWTKEKTLQYKATHSGCSTPEGFRDMLSIRPDHSNVRRMHTAVKL 1151
Query: 2824 NELLLQHSANSQLILLNLPKPPVHKDQQALDDYVHYLEVMTDKLNRVIFVRGTGKEVIT 3000
NE+++ S +++L+LLN+P PP ++ + ++Y+ +LEV+T+ L RV+ VRG G EVIT
Sbjct: 1152 NEVIVNKSHDARLVLLNMPGPP--RNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVIT 1208
>gi|38565928|gb|AAH62099.1| Unknown (protein for MGC:69652) [Mus
musculus]
Length = 1106
Score = 704 bits (1816), Expect = 0.0
Identities = 403/956 (42%), Positives = 564/956 (58%), Gaps = 26/956 (2%)
Frame = +1
Query: 100 LGVLLGVYLPTIQHILGVTMFIRLFWLVGIAGLGQXXXXXXXXXXXXXXXXISISAVATN 279
+G +GVYLP +Q+I GV +F+RL W+VG AG+ Q IS+SA+ATN
Sbjct: 170 MGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGILQAFAIVLICCCCTMLTAISMSAIATN 229
Query: 280 GVVESGGAYFMISRNLGPEFGSAVGILFYLANTVATSMYLVGGVEILLLYIFPGLTFGGV 459
GVV +GG+YFMISR LGPEFG AVG+ FYL T A +MY++G +EI L+YI P
Sbjct: 230 GVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFRS 289
Query: 460 EGQHDTSMFGTMTNSLRFYSTILLLIEFAIVAMGVKFVQMLAPVSLVCVILSILACYAGG 639
+ S M N++R Y T L++ +V +GV++V A + L CVI+SILA YAG
Sbjct: 290 DDALKES--AAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGA 347
Query: 640 VTKTIYPDSGQYVCMYNDRLLQSSAVLNESIPLDEICNYCN-INNTFLADRVCGGRCNST 816
+ + P VCM +R L S + +IC+ ++N + ++ G CNS+
Sbjct: 348 IKSSFAPPHFP-VCMLGNRTLSSRHL--------DICSKTKEVDNMTVPSKLWGFFCNSS 398
Query: 817 TIPHVSPFR--------CINGFPGFQGGQTLLENLGPNYLEKGEAAHGTQADTKSD---- 960
+ + I G PG G + ENL NYL KGE A +
Sbjct: 399 QFFNATCDEYFVHNNVISIQGIPGLASG-IITENLWSNYLPKGEIIEKPSAKSSDVLGNL 457
Query: 961 ----VYQDVRTSFFVLLAIYFPAVTGIFTGANMSGDLKNPQASIPAGTIAANLTTSFVYF 1128
V D+ TSF +L+ I+FP+VTGI G+N SGDLK+ Q SIP GTI A LTTSFVY
Sbjct: 458 NHEYVLADITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYL 517
Query: 1129 SLAFIFGGAIDNAVLRDKNGQSVGGQMVVALLSWPSPWVLLIGSFLSTFGAALQCLCSAP 1308
S +FG I+ VLRDK G +V G +VV LSWPSPWV++IGSF ST GA LQ L AP
Sbjct: 518 SNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAP 577
Query: 1309 RLLQAIAKDEVIPLLSPFKKVTANNEPFXXXXXXXXXXXXXXXMGSMDTIAAVVDFFFLM 1488
RLLQAIAKD +IP L F AN EP + S+D +A ++ FFLM
Sbjct: 578 RLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLM 637
Query: 1489 CYAFVNIICTLHSLLGAPNWRPRFKYYHWFLSLLGAVLCFFIMFSTHWDYAIVACLLCLV 1668
CY FVN+ C L +LL PNWRPRF+YYHW LS +G +C +MF + W YAIVA ++ +
Sbjct: 638 CYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGM 697
Query: 1669 IYKYVEWKGAKKEWGDGIRGLALTTAQYSLMKIEDKEPHPKNWRPQLLLLLSMQWSKEII 1848
IYKY+E++GA+KEWGDGIRGL+L+ A+++L+++E+ PH KNWRPQLL+LL + E +
Sbjct: 698 IYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLD---EDL 754
Query: 1849 DVRYLNLLNLASQLKAGKGLTVVTAFLQGD-PTSPDDKKKGEQVKARMDFDMNQVRLRGF 2025
V++ LL ASQLKAGKGLT+V + + G+ + D EQ + M +++GF
Sbjct: 755 HVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGDALAAEQTIKHL---MEAEKVKGF 811
Query: 2026 AKTLVHSEDQVRGSMSTLVQSVGLGGLKPNTMLISWPVHERE-EDMTEYNTFIEKVHAAS 2202
+ +V + +++ +S L+QS GLGG+K NT+++ WP R+ ED + TFI V +
Sbjct: 812 CQLVVAA--KLKEGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTT 869
Query: 2203 INDMAIVVAKGIIDFPSAVFRMS-GMIDVYWIVHDGGLCLLMGYLLKQHKVWRGCKLRVI 2379
+A++VAK + FPS V + S G IDV+WIVHDGG+ +L+ +LLKQHKVWR C +R+
Sbjct: 870 AAHLALLVAKNVSFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIF 929
Query: 2380 GIAQESDNNVKMQEDLQKYVYQLRIDAKIMIVELADPEISKNAFERTLLMEERTMMMRDL 2559
+AQ DN+++M++DL ++Y LRI+A++ +VE+ D +IS +ERTL+ME+R+ M+R
Sbjct: 930 TVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRH- 988
Query: 2560 QKVSGGGMSLSLPPANAPRAPSPLVTSERRANSKXXXXXXXXXXXXXXXXXXXXXXXXQA 2739
M LS + S R S A
Sbjct: 989 -------MRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMA 1041
Query: 2740 NQETKTKK-ERMKAL-----DRSKVSKMHTAVRLNELLLQHSANSQLILLNLPKPP 2889
++ K K E + L D+S V +MHTAV+LNE+++ S ++L+LLN+P PP
Sbjct: 1042 SRGQKVKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPP 1097
>gi|27151685|sp|Q91V14|S125_MOUSE Solute carrier family 12 member 5
(Electroneutral potassium-chloride cotransporter 2) (K-Cl
cotransporter 2) (Neuronal K-Cl cotransporter) (mKCC2)
gi|14193694|gb|AAK56092.1| K-Cl cotransporter [Mus musculus]
gi|14193696|gb|AAK56093.1| K-Cl cotransporter [Mus musculus]
Length = 1115
Score = 701 bits (1809), Expect = 0.0
Identities = 406/1036 (39%), Positives = 591/1036 (56%), Gaps = 69/1036 (6%)
Frame = +1
Query: 100 LGVLLGVYLPTIQHILGVTMFIRLFWLVGIAGLGQXXXXXXXXXXXXXXXXISISAVATN 279
+G +GVYLP +Q+I GV +F+RL W+VGIAG+ + IS+SA+ATN
Sbjct: 97 MGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATN 156
Query: 280 GVVESGGAYFMISRNLGPEFGSAVGILFYLANTVATSMYLVGGVEILLLYIFPGLTFGGV 459
GVV +GG+Y+MISR+LGPEFG AVG+ FYL T A +MY++G +EILL Y+FP +
Sbjct: 157 GVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKA 216
Query: 460 EGQHDTSMFGTMTNSLRFYSTILLLIEFAIVAMGVKFVQMLAPVSLVCVILSILACYAGG 639
E + M N++R Y T +L +V +GVK+V A V L CVILSILA YAG
Sbjct: 217 EDASGEA--AAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAG- 273
Query: 640 VTKTIYPDSGQYVCMYNDRLLQSSAVLNESIPLDEICNYCNINNTFLADRVCGGRCNSTT 819
V K+ + +C+ +R L D N + R+ G C+S
Sbjct: 274 VIKSAFDPPNFPICLLGNRTLSRHG-------FDVCAKLAWEGNETVTTRLWGLFCSSRL 326
Query: 820 IPHV-------SPFRCINGFPGFQGGQTLLENLGPNYLEKGEA-----------AHGTQA 945
+ + I G PG G + ENL +YL KG A GT
Sbjct: 327 LNATCDEYFTRNNVTEIQGIPGAASG-LIKENLWSSYLTKGVIVERRGMPSVGLADGTPV 385
Query: 946 DTKSD-VYQDVRTSFFVLLAIYFPAVTGIFTGANMSGDLKNPQASIPAGTIAANLTTSFV 1122
D V+ D+ + F +L+ IYFP+VTGI G+N SGDL++ Q SIP GTI A TTS V
Sbjct: 386 DMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAV 445
Query: 1123 YFSLAFIFGGAIDNAVLRDKNGQSVGGQMVVALLSWPSPWVLLIGSFLSTFGAALQCLCS 1302
Y S +FG I+ VLRDK G++V G +VV L+WPSPWV++IGSF ST GA LQ L
Sbjct: 446 YISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTG 505
Query: 1303 APRLLQAIAKDEVIPLLSPFKKVTANNEPFXXXXXXXXXXXXXXXMGSMDTIAAVVDFFF 1482
APRLLQAI++D ++P L F AN EP + S+D +A ++ FF
Sbjct: 506 APRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFF 565
Query: 1483 LMCYAFVNIICTLHSLLGAPNWRPRFKYYHWFLSLLGAVLCFFIMFSTHWDYAIVACLLC 1662
LMCY FVN+ C + +LL PNWRPRF+YYHW LS LG LC +MF W YA+VA L+
Sbjct: 566 LMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIA 625
Query: 1663 LVIYKYVEWKGAKKEWGDGIRGLALTTAQYSLMKIEDKEPHPKNWRPQLLLLLSMQWSKE 1842
+IYKY+E++GA+KEWGDGIRGL+L+ A+Y+L+++E+ PH KNWRPQLL+L+ + +
Sbjct: 626 GLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQN 685
Query: 1843 IIDVRYLNLLNLASQLKAGKGLTVVTAFLQGDPTSPDDKKKGEQVKARMDFDMNQVRLRG 2022
++ + LL+L SQLKAGKGLT+V + L+G T D+ + ++ + + M +++G
Sbjct: 686 VV---HPQLLSLTSQLKAGKGLTIVGSVLEG--TFLDNHPQAQRAEESIRRLMEAEKVKG 740
Query: 2023 FAKTLVHSEDQVRGSMSTLVQSVGLGGLKPNTMLISWPVHERE-EDMTEYNTFIEKVHAA 2199
F + ++ S +R +S L+QS GLGGL+ NT+L+ WP + R+ ED + FIE V
Sbjct: 741 FCQVVISSN--LRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRET 798
Query: 2200 SINDMAIVVAKGIIDFPSAVFRMS-GMIDVYWIVHDGGLCLLMGYLLKQHKVWRGCKLRV 2376
+ +A++V K + FP R S G IDV+WIVHDGG+ +L+ +LL+ HKVWR CK+R+
Sbjct: 799 TAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRI 858
Query: 2377 IGIAQESDNNVKMQEDLQKYVYQLRIDAKIMIVELADPEISKNAFERT------------ 2520
+AQ DN+++M++DL ++Y LRI A++ +VE+ + +IS +E+T
Sbjct: 859 FTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQ 918
Query: 2521 --LLMEERTMMMRDLQKVSGGG----------MSLSLP---------------------- 2598
L ER ++ + S G + L++P
Sbjct: 919 MHLTKNEREREIQSITDESRGSIRRKNPANPRLRLNVPEETACDNEEKPEEEVQLIHDQS 978
Query: 2599 -PANAPRAPSPLVTSE-RRANSKXXXXXXXXXXXXXXXXXXXXXXXXQANQETKTKKERM 2772
P+ +PSP E R + ++ + K
Sbjct: 979 APSCPSSSPSPGEEPEGERETDPEVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKPEW 1038
Query: 2773 KALDRSKVSKMHTAVRLNELLLQHSANSQLILLNLPKPPVHKDQQALDDYVHYLEVMTDK 2952
+ L++S V +MHTAVRLNE+++ S +++L+LLN+P PP +++ ++Y+ +LEV+T++
Sbjct: 1039 ENLNQSNVRRMHTAVRLNEVIVNKSRDAKLVLLNMPGPP--RNRNGDENYMEFLEVLTEQ 1096
Query: 2953 LNRVIFVRGTGKEVIT 3000
L+RV+ VRG G+EVIT
Sbjct: 1097 LDRVMLVRGGGREVIT 1112
>gi|28972652|dbj|BAC65742.1| mKIAA1176 protein [Mus musculus]
Length = 1164
Score = 701 bits (1809), Expect = 0.0
Identities = 406/1036 (39%), Positives = 591/1036 (56%), Gaps = 69/1036 (6%)
Frame = +1
Query: 100 LGVLLGVYLPTIQHILGVTMFIRLFWLVGIAGLGQXXXXXXXXXXXXXXXXISISAVATN 279
+G +GVYLP +Q+I GV +F+RL W+VGIAG+ + IS+SA+ATN
Sbjct: 146 MGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATN 205
Query: 280 GVVESGGAYFMISRNLGPEFGSAVGILFYLANTVATSMYLVGGVEILLLYIFPGLTFGGV 459
GVV +GG+Y+MISR+LGPEFG AVG+ FYL T A +MY++G +EILL Y+FP +
Sbjct: 206 GVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKA 265
Query: 460 EGQHDTSMFGTMTNSLRFYSTILLLIEFAIVAMGVKFVQMLAPVSLVCVILSILACYAGG 639
E + M N++R Y T +L +V +GVK+V A V L CVILSILA YAG
Sbjct: 266 EDASGEA--AAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAG- 322
Query: 640 VTKTIYPDSGQYVCMYNDRLLQSSAVLNESIPLDEICNYCNINNTFLADRVCGGRCNSTT 819
V K+ + +C+ +R L D N + R+ G C+S
Sbjct: 323 VIKSAFDPPNFPICLLGNRTLSRHG-------FDVCAKLAWEGNETVTTRLWGLFCSSRL 375
Query: 820 IPHV-------SPFRCINGFPGFQGGQTLLENLGPNYLEKGEA-----------AHGTQA 945
+ + I G PG G + ENL +YL KG A GT
Sbjct: 376 LNATCDEYFTRNNVTEIQGIPGAASG-LIKENLWSSYLTKGVIVERRGMPSVGLADGTPV 434
Query: 946 DTKSD-VYQDVRTSFFVLLAIYFPAVTGIFTGANMSGDLKNPQASIPAGTIAANLTTSFV 1122
D V+ D+ + F +L+ IYFP+VTGI G+N SGDL++ Q SIP GTI A TTS V
Sbjct: 435 DMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAV 494
Query: 1123 YFSLAFIFGGAIDNAVLRDKNGQSVGGQMVVALLSWPSPWVLLIGSFLSTFGAALQCLCS 1302
Y S +FG I+ VLRDK G++V G +VV L+WPSPWV++IGSF ST GA LQ L
Sbjct: 495 YISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTG 554
Query: 1303 APRLLQAIAKDEVIPLLSPFKKVTANNEPFXXXXXXXXXXXXXXXMGSMDTIAAVVDFFF 1482
APRLLQAI++D ++P L F AN EP + S+D +A ++ FF
Sbjct: 555 APRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFF 614
Query: 1483 LMCYAFVNIICTLHSLLGAPNWRPRFKYYHWFLSLLGAVLCFFIMFSTHWDYAIVACLLC 1662
LMCY FVN+ C + +LL PNWRPRF+YYHW LS LG LC +MF W YA+VA L+
Sbjct: 615 LMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIA 674
Query: 1663 LVIYKYVEWKGAKKEWGDGIRGLALTTAQYSLMKIEDKEPHPKNWRPQLLLLLSMQWSKE 1842
+IYKY+E++GA+KEWGDGIRGL+L+ A+Y+L+++E+ PH KNWRPQLL+L+ + +
Sbjct: 675 GLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQN 734
Query: 1843 IIDVRYLNLLNLASQLKAGKGLTVVTAFLQGDPTSPDDKKKGEQVKARMDFDMNQVRLRG 2022
++ + LL+L SQLKAGKGLT+V + L+G T D+ + ++ + + M +++G
Sbjct: 735 VV---HPQLLSLTSQLKAGKGLTIVGSVLEG--TFLDNHPQAQRAEESIRRLMEAEKVKG 789
Query: 2023 FAKTLVHSEDQVRGSMSTLVQSVGLGGLKPNTMLISWPVHERE-EDMTEYNTFIEKVHAA 2199
F + ++ S +R +S L+QS GLGGL+ NT+L+ WP + R+ ED + FIE V
Sbjct: 790 FCQVVISSN--LRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRET 847
Query: 2200 SINDMAIVVAKGIIDFPSAVFRMS-GMIDVYWIVHDGGLCLLMGYLLKQHKVWRGCKLRV 2376
+ +A++V K + FP R S G IDV+WIVHDGG+ +L+ +LL+ HKVWR CK+R+
Sbjct: 848 TAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRI 907
Query: 2377 IGIAQESDNNVKMQEDLQKYVYQLRIDAKIMIVELADPEISKNAFERT------------ 2520
+AQ DN+++M++DL ++Y LRI A++ +VE+ + +IS +E+T
Sbjct: 908 FTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQ 967
Query: 2521 --LLMEERTMMMRDLQKVSGGG----------MSLSLP---------------------- 2598
L ER ++ + S G + L++P
Sbjct: 968 MHLTKNEREREIQSITDESRGSIRRKNPANPRLRLNVPEETACDNEEKPEEEVQLIHDQS 1027
Query: 2599 -PANAPRAPSPLVTSE-RRANSKXXXXXXXXXXXXXXXXXXXXXXXXQANQETKTKKERM 2772
P+ +PSP E R + ++ + K
Sbjct: 1028 APSCPSSSPSPGEEPEGERETDPEVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKPEW 1087
Query: 2773 KALDRSKVSKMHTAVRLNELLLQHSANSQLILLNLPKPPVHKDQQALDDYVHYLEVMTDK 2952
+ L++S V +MHTAVRLNE+++ S +++L+LLN+P PP +++ ++Y+ +LEV+T++
Sbjct: 1088 ENLNQSNVRRMHTAVRLNEVIVNKSRDAKLVLLNMPGPP--RNRNGDENYMEFLEVLTEQ 1145
Query: 2953 LNRVIFVRGTGKEVIT 3000
L+RV+ VRG G+EVIT
Sbjct: 1146 LDRVMLVRGGGREVIT 1161
>gi|33859680|ref|NP_065066.1| solute carrier family 12, member 5 [Mus
musculus]
gi|32451783|gb|AAH54808.1| Solute carrier family 12, member 5 [Mus
musculus]
Length = 1114
Score = 701 bits (1809), Expect = 0.0
Identities = 406/1036 (39%), Positives = 591/1036 (56%), Gaps = 69/1036 (6%)
Frame = +1
Query: 100 LGVLLGVYLPTIQHILGVTMFIRLFWLVGIAGLGQXXXXXXXXXXXXXXXXISISAVATN 279
+G +GVYLP +Q+I GV +F+RL W+VGIAG+ + IS+SA+ATN
Sbjct: 96 MGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATN 155
Query: 280 GVVESGGAYFMISRNLGPEFGSAVGILFYLANTVATSMYLVGGVEILLLYIFPGLTFGGV 459
GVV +GG+Y+MISR+LGPEFG AVG+ FYL T A +MY++G +EILL Y+FP +
Sbjct: 156 GVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKA 215
Query: 460 EGQHDTSMFGTMTNSLRFYSTILLLIEFAIVAMGVKFVQMLAPVSLVCVILSILACYAGG 639
E + M N++R Y T +L +V +GVK+V A V L CVILSILA YAG
Sbjct: 216 EDASGEA--AAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAG- 272
Query: 640 VTKTIYPDSGQYVCMYNDRLLQSSAVLNESIPLDEICNYCNINNTFLADRVCGGRCNSTT 819
V K+ + +C+ +R L D N + R+ G C+S
Sbjct: 273 VIKSAFDPPNFPICLLGNRTLSRHG-------FDVCAKLAWEGNETVTTRLWGLFCSSRL 325
Query: 820 IPHV-------SPFRCINGFPGFQGGQTLLENLGPNYLEKGEA-----------AHGTQA 945
+ + I G PG G + ENL +YL KG A GT
Sbjct: 326 LNATCDEYFTRNNVTEIQGIPGAASG-LIKENLWSSYLTKGVIVERRGMPSVGLADGTPV 384
Query: 946 DTKSD-VYQDVRTSFFVLLAIYFPAVTGIFTGANMSGDLKNPQASIPAGTIAANLTTSFV 1122
D V+ D+ + F +L+ IYFP+VTGI G+N SGDL++ Q SIP GTI A TTS V
Sbjct: 385 DMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAV 444
Query: 1123 YFSLAFIFGGAIDNAVLRDKNGQSVGGQMVVALLSWPSPWVLLIGSFLSTFGAALQCLCS 1302
Y S +FG I+ VLRDK G++V G +VV L+WPSPWV++IGSF ST GA LQ L
Sbjct: 445 YISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTG 504
Query: 1303 APRLLQAIAKDEVIPLLSPFKKVTANNEPFXXXXXXXXXXXXXXXMGSMDTIAAVVDFFF 1482
APRLLQAI++D ++P L F AN EP + S+D +A ++ FF
Sbjct: 505 APRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFF 564
Query: 1483 LMCYAFVNIICTLHSLLGAPNWRPRFKYYHWFLSLLGAVLCFFIMFSTHWDYAIVACLLC 1662
LMCY FVN+ C + +LL PNWRPRF+YYHW LS LG LC +MF W YA+VA L+
Sbjct: 565 LMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIA 624
Query: 1663 LVIYKYVEWKGAKKEWGDGIRGLALTTAQYSLMKIEDKEPHPKNWRPQLLLLLSMQWSKE 1842
+IYKY+E++GA+KEWGDGIRGL+L+ A+Y+L+++E+ PH KNWRPQLL+L+ + +
Sbjct: 625 GLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQN 684
Query: 1843 IIDVRYLNLLNLASQLKAGKGLTVVTAFLQGDPTSPDDKKKGEQVKARMDFDMNQVRLRG 2022
++ + LL+L SQLKAGKGLT+V + L+G T D+ + ++ + + M +++G
Sbjct: 685 VV---HPQLLSLTSQLKAGKGLTIVGSVLEG--TFLDNHPQAQRAEESIRRLMEAEKVKG 739
Query: 2023 FAKTLVHSEDQVRGSMSTLVQSVGLGGLKPNTMLISWPVHERE-EDMTEYNTFIEKVHAA 2199
F + ++ S +R +S L+QS GLGGL+ NT+L+ WP + R+ ED + FIE V
Sbjct: 740 FCQVVISSN--LRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRET 797
Query: 2200 SINDMAIVVAKGIIDFPSAVFRMS-GMIDVYWIVHDGGLCLLMGYLLKQHKVWRGCKLRV 2376
+ +A++V K + FP R S G IDV+WIVHDGG+ +L+ +LL+ HKVWR CK+R+
Sbjct: 798 TAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRI 857
Query: 2377 IGIAQESDNNVKMQEDLQKYVYQLRIDAKIMIVELADPEISKNAFERT------------ 2520
+AQ DN+++M++DL ++Y LRI A++ +VE+ + +IS +E+T
Sbjct: 858 FTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQ 917
Query: 2521 --LLMEERTMMMRDLQKVSGGG----------MSLSLP---------------------- 2598
L ER ++ + S G + L++P
Sbjct: 918 MHLTKNEREREIQSITDESRGSIRRKNPANPRLRLNVPEETACDNEEKPEEEVQLIHDQS 977
Query: 2599 -PANAPRAPSPLVTSE-RRANSKXXXXXXXXXXXXXXXXXXXXXXXXQANQETKTKKERM 2772
P+ +PSP E R + ++ + K
Sbjct: 978 APSCPSSSPSPGEEPEGERETDPEVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKPEW 1037
Query: 2773 KALDRSKVSKMHTAVRLNELLLQHSANSQLILLNLPKPPVHKDQQALDDYVHYLEVMTDK 2952
+ L++S V +MHTAVRLNE+++ S +++L+LLN+P PP +++ ++Y+ +LEV+T++
Sbjct: 1038 ENLNQSNVRRMHTAVRLNEVIVNKSRDAKLVLLNMPGPP--RNRNGDENYMEFLEVLTEQ 1095
Query: 2953 LNRVIFVRGTGKEVIT 3000
L+RV+ VRG G+EVIT
Sbjct: 1096 LDRVMLVRGGGREVIT 1111
>gi|3015639|gb|AAC39684.1| erythroid K:Cl cotransporter splicing
isoform 1 [Homo sapiens]
Length = 1011
Score = 696 bits (1797), Expect = 0.0
Identities = 387/869 (44%), Positives = 536/869 (61%), Gaps = 25/869 (2%)
Frame = +1
Query: 31 HITPGPLERAQSSSHGGHGAKA----DLGVLLGVYLPTIQHILGVTMFIRLFWLVGIAGL 198
++T G E ++ S G +A +G L+GVYLP +Q+I GV +F+RL W+VG AG+
Sbjct: 91 NLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGV 150
Query: 199 GQXXXXXXXXXXXXXXXXISISAVATNGVVESGGAYFMISRNLGPEFGSAVGILFYLANT 378
Q IS+SA+ATNGVV +GG+YFMISR+LGPEFG AVG+ FYL T
Sbjct: 151 LQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTT 210
Query: 379 VATSMYLVGGVEILLLYIFPGLTFGGVEGQHDTSMFGTMTNSLRFYSTILLLIEFAIVAM 558
A +MY++G +EILL YI P G HDTS N++R Y TI L +V +
Sbjct: 211 FAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTS--NATLNNMRVYGTIFLTFMTLVVFV 268
Query: 559 GVKFVQMLAPVSLVCVILSILACYAGGVTKTIYPDSGQYVCMYNDRLLQSSAVLNESIPL 738
GVK+V A + L CVI+SIL+ YAGG+ K+I+ VCM +R L
Sbjct: 269 GVKYVNKFASLFLACVIISILSIYAGGI-KSIFDPPVFPVCMLGNRTLSRDQ-------F 320
Query: 739 DEICNYCNINNTFLADRVCGGRCNST--TIPHVSPFRCIN------GFPGFQGGQTLLEN 894
D ++N +A ++ C+S T P+ +N G PG G L EN
Sbjct: 321 DICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAG-VLQEN 379
Query: 895 LGPNYLEKGEAA--HGT-QADTKS-------DVYQDVRTSFFVLLAIYFPAVTGIFTGAN 1044
L YLEKG+ HG AD S V D+ TSF VL+ I+FP+VTGI G+N
Sbjct: 380 LWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGSN 439
Query: 1045 MSGDLKNPQASIPAGTIAANLTTSFVYFSLAFIFGGAIDNAVLRDKNGQSVGGQMVVALL 1224
SGDL++ Q SIP GTI A +TTS VYFS +FG I+ VLRDK G V +VV L
Sbjct: 440 RSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTL 499
Query: 1225 SWPSPWVLLIGSFLSTFGAALQCLCSAPRLLQAIAKDEVIPLLSPFKKVTANNEPFXXXX 1404
+WPSPWV++IGSF ST GA LQ L APRLLQAIAKD +IP L F N EP
Sbjct: 500 AWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALL 559
Query: 1405 XXXXXXXXXXXMGSMDTIAAVVDFFFLMCYAFVNIICTLHSLLGAPNWRPRFKYYHWFLS 1584
+ S+D +A ++ FFLMCY FVN+ C + +LL PNWRPRFKYYHW LS
Sbjct: 560 LTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALS 619
Query: 1585 LLGAVLCFFIMFSTHWDYAIVACLLCLVIYKYVEWKGAKKEWGDGIRGLALTTAQYSLMK 1764
LG LC +MF + W YA+VA L+ +IYKY+E++GA+KEWGDGIRGL+L+ A+Y+L++
Sbjct: 620 FLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLR 679
Query: 1765 IEDKEPHPKNWRPQLLLLLSMQWSKEIIDVRYLNLLNLASQLKAGKGLTVVTAFLQGD-P 1941
+E+ PH KNWRPQLL+LL + E + V+Y LL ASQLKAGKGLT+V + +QG
Sbjct: 680 LEEGPPHTKNWRPQLLVLLKLD---EDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFL 736
Query: 1942 TSPDDKKKGEQVKARMDFDMNQVRLRGFAKTLVHSEDQVRGSMSTLVQSVGLGGLKPNTM 2121
S + + EQ M M +++GF + +V S +VR ++ L+QS GLGG++ N++
Sbjct: 737 ESYGEAQAAEQTIKNM---MEIEKVKGFCQVVVAS--KVREGLAHLIQSCGLGGMRHNSV 791
Query: 2122 LISWPVHERE-EDMTEYNTFIEKVHAASINDMAIVVAKGIIDFPSAVFR-MSGMIDVYWI 2295
++ WP R+ ED + TFI+ V + +A++V K I +PS R + G IDV+WI
Sbjct: 792 VLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWI 851
Query: 2296 VHDGGLCLLMGYLLKQHKVWRGCKLRVIGIAQESDNNVKMQEDLQKYVYQLRIDAKIMIV 2475
VHDGG+ +L+ +LL+QHKVWR C++R+ +AQ DN+++M++DL ++Y LR++A++ +V
Sbjct: 852 VHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEVV 911
Query: 2476 ELADPEISKNAFERTLLMEERTMMMRDLQ 2562
E+ + +IS +ERTL+ME+R+ M+R ++
Sbjct: 912 EMHNSDISAYTYERTLMMEQRSQMLRQMR 940
>gi|47225214|emb|CAF98841.1| unnamed protein product [Tetraodon
nigroviridis]
Length = 1148
Score = 695 bits (1794), Expect = 0.0
Identities = 421/1087 (38%), Positives = 597/1087 (54%), Gaps = 88/1087 (8%)
Frame = +1
Query: 4 PFFSSYLK-----AHITPGPLERAQSSSHGGHGAKA---DLGVLLGVYLPTIQHILGVTM 159
P SS L ++T G E + G +G +GVYLP +Q+ILGV +
Sbjct: 82 PMVSSLLNKLANYTNLTQGAQEHEEEEEQGAKKKAVKSPQMGTFMGVYLPCLQNILGVIL 141
Query: 160 FIRLFWLVGIAGLGQXXXXXXXXXXXXXXXXISISAVATNGVVESGGAYFMISRNLGPEF 339
F+RL W+VG AG+ + IS+SA+ATNGVV +GG+Y+MISR+LGPEF
Sbjct: 142 FLRLTWIVGTAGILESMAIVGLCCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEF 201
Query: 340 GSAVGILFYLANTVATSMYLVGGVEILLLYIFPGLTFGGVEGQHDTSMFGTMTNSLRFYS 519
G AVG+ FYL T A SMY++G +EILL YI P E + D + G + N++R Y
Sbjct: 202 GGAVGLCFYLGTTFAGSMYILGTIEILLTYIVPKAAIFVAEKKEDEA--GALLNNMRVYG 259
Query: 520 TILLLIEFAIVAMGVKFVQMLAPVSLVCVILSILACYAGGVTKTIYPDSGQYVCMYNDRL 699
T L + +V +GVK+V LA V L CVILSI+A YAG V KTI+ VCM +R
Sbjct: 260 TCCLALMAIVVFVGVKYVNKLALVFLACVILSIIAIYAG-VIKTIFEPPDFPVCMLGNRT 318
Query: 700 LQSSAVLNESIPLDEICNYCNINNTFLADRVCGG-RCNSTTIPHVSP--FRCINGFPGFQ 870
LQ+ + + D + N +L C G N+T + + + G PG +
Sbjct: 319 LQNHN-FDRCLKTDVVDNLTVTTELWLL--FCDGPELNATCNDYFANNNVTLMQGIPGLK 375
Query: 871 GGQTLLENLGPNY------LEKGEAAHGTQADTKSD-----VYQDVRTSFFVLLAIYFPA 1017
G + EN+ Y +E E +D D V D+ T F +L+ IYFP+
Sbjct: 376 SG-VISENMWSQYGPRSMLVENKELLSSGGSDGAEDIKMPYVVNDIATFFTLLVGIYFPS 434
Query: 1018 VTGIFTGANMSGDLKNPQASIPAGTIAANLTTSFVYFSLAF------------------- 1140
VTGI G+N SGDL++ Q SIP GTI A +TTS + F
Sbjct: 435 VTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSIICILQVFQCSTKNGNLLVILLILRMF 494
Query: 1141 ------------------IFGGAIDNAVLRDKNGQSVGGQMVVALLSWPSPWVLLIGSFL 1266
+FG I+ +LRDK G SV G +V+ LSWPSPWV++IGSF
Sbjct: 495 LRHTFPLLNWASDMTCVVLFGACIEGVLLRDKFGDSVKGNLVIGTLSWPSPWVIVIGSFF 554
Query: 1267 STFGAALQCLCSAPRLLQAIAKDEVIPLLSPFKKVTANNEPFXXXXXXXXXXXXXXXMGS 1446
S GA LQ L APRLLQAIA+D ++P L F AN EP + S
Sbjct: 555 SCCGAGLQSLTGAPRLLQAIARDGIVPFLQVFGHGKANGEPTWALLLTAGICEIGILIAS 614
Query: 1447 MDTIAAVVDFFFLMCYAFVNIICTLHSLLGAPNWRPRFKYYHWFLSLLGAVLCFFIMFST 1626
+D +A ++ FFLMCY FVN+ C + +LL PNWRPRFKYYHW LS LG LC +MF +
Sbjct: 615 LDAVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWTLSFLGMSLCLALMFIS 674
Query: 1627 HWDYAIVACLLCLVIYKYVEWKGAKKEWGDGIRGLALTTAQYSLMKIEDKEPHPKNWRPQ 1806
W YAIVA + IYKY+E++GA+KEWGDGIRGL+L A+++L+++E+ PH KNWRPQ
Sbjct: 675 SWYYAIVAMAIASCIYKYIEYRGAEKEWGDGIRGLSLNAARFALIRLEEAPPHTKNWRPQ 734
Query: 1807 LLLLLSMQWSKEIIDVRYLNLLNLASQLKAGKGLTVVTAFLQGD-PTSPDDKKKGEQVKA 1983
LL+LL++ S+++ V++ LL+ +QLKAGKGLT+V L+G T + KK EQ
Sbjct: 735 LLVLLNVD-SEQV--VKHPRLLSFTTQLKAGKGLTIVGNILEGTYLTKEAEAKKAEQ--- 788
Query: 1984 RMDFDMNQVRLRGFAKTLVHSEDQVRGSMSTLVQSVGLGGLKPNTMLISWPVHERE-EDM 2160
+ M R +GF +V S +R S L+QS GLGG+K NT+L++WP + R+ D
Sbjct: 789 NIKTSMAAERTKGFCHVVVSS--NLRDGFSHLIQSAGLGGMKHNTVLMAWPGNWRQSNDA 846
Query: 2161 TEYNTFIEKVHAASINDMAIVVAKGIIDFPSAVFRMS-GMIDVYWIVHDGGLCLLMGYLL 2337
+ F E V + A++VAK + +FP R++ G IDV+W+VHDGG+ +L+ +LL
Sbjct: 847 QSWRNFTETVRETTTAHQALLVAKNVDNFPGNQERLAEGTIDVWWVVHDGGMLMLLPFLL 906
Query: 2338 KQHK-------------------------VWRGCKLRVIGIAQESDNNVKMQEDLQKYVY 2442
+QHK VWR CK+R+ +AQ DN+++M++DLQ ++Y
Sbjct: 907 RQHKVSPSGWSLRPTRLFSPSRPCLVVLQVWRKCKMRIFTVAQMDDNSIQMKKDLQMFLY 966
Query: 2443 QLRIDAKIMIVELADPEISKNAFERTLLMEERTMMMRDLQKVSGGGMSLSLPPANAPRAP 2622
LR+DA++ +VE+ D +IS +E+TL+ME+R+ M++ +Q +S + A
Sbjct: 967 HLRLDAEVEVVEMHDNDISAFTYEKTLVMEQRSQMLKQMQ------LSRTEREREAQLIH 1020
Query: 2623 SPLVTSERRANSKXXXX-XXXXXXXXXXXXXXXXXXXXQANQETKTKKERMKALDRSKVS 2799
S N K +AN + ++S V
Sbjct: 1021 DRNTASHAAVNDKEDGVPERVHMTWTKDKLFTERLRNREANAGVAVRDLFNMRPNQSNVR 1080
Query: 2800 KMHTAVRLNELLLQHSANSQLILLNLPKPPVHKDQQALDDYVHYLEVMTDKLNRVIFVRG 2979
+MHTAV+LNE+++ S +QL+LLN+P PP K + ++Y+ +LEV+ + LNRV+ VRG
Sbjct: 1081 RMHTAVKLNEVVVNKSQGAQLVLLNMPGPP--KSRGGDENYMEFLEVLMEGLNRVLLVRG 1138
Query: 2980 TGKEVIT 3000
G+EVIT
Sbjct: 1139 GGREVIT 1145
>gi|19705463|ref|NP_599190.1| solute carrier family 12 member 5
[Rattus norvegicus]
gi|27151682|sp|Q63633|S125_RAT Solute carrier family 12 member 5
(Electroneutral potassium-chloride cotransporter 2) (K-Cl
cotransporter 2) (Neuronal K-Cl cotransporter)
(Furosemide-sensitive K-Cl cotransporter) (rKCC2)
gi|7513993|pir||T31432 K-Cl cotransport protein 2,
furosemide-sensitive - rat
gi|1403709|gb|AAC52635.1| furosemide-sensitive K-Cl cotransporter
Length = 1116
Score = 687 bits (1772), Expect = 0.0
Identities = 404/1039 (38%), Positives = 590/1039 (55%), Gaps = 72/1039 (6%)
Frame = +1
Query: 100 LGVLLGVYLPTIQHILGVTMFIRLFWLVGIAGLGQXXXXXXXXXXXXXXXXISISAVATN 279
+G +GVYLP +Q+I GV +F+RL W+VGIAG+ + IS+SA+ATN
Sbjct: 97 MGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATN 156
Query: 280 GVVESGGAYFMISRNLGPEFGSAVGILFYLANTVATSMYLVGGVEILLLYIFPGLTFGGV 459
GVV +GG+Y+MISR+LGPEFG AVG+ FYL T A +MY++G +EILL Y+FP +
Sbjct: 157 GVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKA 216
Query: 460 EGQHDTSMFGTMTNSLRFYSTILLLIEFAIVAMGVKFVQMLAPVSLVCVILSILACYAGG 639
E + M N++R Y T +L +V +GVK+V A V L CVILSILA YAG
Sbjct: 217 EDASGEA--AAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAG- 273
Query: 640 VTKTIYPDSGQYVCMYNDRLLQSSAVLNESIPLDEICNYCNINNTFLADRVCGGRCNSTT 819
V K+ + +C+ +R L D N + R+ G C+S
Sbjct: 274 VIKSAFDPPNFPICLLGNRTLSRHG-------FDVCAKLAWEGNETVTTRLWGLFCSSRL 326
Query: 820 IPHV-------SPFRCINGFPGFQGGQTLLENLGPNYLEKGEA-----------AHGTQA 945
+ + I G PG G + ENL +YL KG A GT
Sbjct: 327 LNATCDEYFTRNNVTEIQGIPGAASG-LIKENLWSSYLTKGVIVERRGMPSVGLADGTPV 385
Query: 946 DTKSD-VYQDVRTSFFVLLAIYFPAVTGIFTGANMSGDLKNPQASIPAGTIAANLTTSFV 1122
D V+ D+ + F +L+ IYFP+VTGI G+N SGDL++ Q SIP GTI A TTS V
Sbjct: 386 DMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAV 445
Query: 1123 YFSLAFIFGGAIDNAVLRDKNGQSVGGQMVVALLSWPSPWVLLIGSFLSTFGAALQCLCS 1302
Y S +FG I+ VLRDK G++V G +VV L+WPSPWV++IGSF ST GA LQ L
Sbjct: 446 YISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTG 505
Query: 1303 APRLLQAIAKDEVIPLLSPFKKVTANNEPFXXXXXXXXXXXXXXXMGSMDTIAAVVDFFF 1482
APRLLQAI++D ++P L F AN EP + S+D +A ++ FF
Sbjct: 506 APRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFF 565
Query: 1483 LMCYAFVNIICTLHSLLGAPNWRPRFKYYHWFLSLLGAVLCFFIMFSTHWDYAIVACLLC 1662
LMCY FVN+ C + +LL PNWRPRF+YYHW LS LG LC +MF W YA+VA L+
Sbjct: 566 LMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIA 625
Query: 1663 LVIYKYVEWKGAKKEWGDGIRGLALTTAQYSLMKIEDKEPHPKNWRPQLLLLLSMQWSKE 1842
+IYKY+E++GA+KEWGDGIRGL+L+ A+Y+L+++E+ PH KNWRPQLL+L+ + +
Sbjct: 626 GLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQN 685
Query: 1843 IIDVRYLNLLNLASQLKAGKGLTVVTAFLQGDPTSPDDKKKGEQVKARMDFDMNQVRLRG 2022
++ + LL+L SQLKAGKGLT+V + L+G T D+ + ++ + + M +++G
Sbjct: 686 VV---HPQLLSLTSQLKAGKGLTIVGSVLEG--TFLDNHPQAQRAEESIRRLMEAEKVKG 740
Query: 2023 FAKTLVHSEDQVRGSMSTLVQSVGLGGLKPNTMLISWPVHERE-EDMTEYNTFIEKVHAA 2199
F + ++ S +R +S L+QS GLGGL+ NT+L+ WP + R+ ED + FIE V
Sbjct: 741 FCQVVISSN--LRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRET 798
Query: 2200 SINDMAIVVAKGIIDFPSAVFRMS-GMIDVYWIVHDGGLCLLMGYLLKQHKVWRGCKLRV 2376
+ +A++V K + FP R S G IDV+WIVHDGG+ +L+ +LL+ HKVWR CK+R+
Sbjct: 799 TAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRI 858
Query: 2377 IGIAQESDNNVKMQEDLQKYVYQLRIDA------------------KIMIVE-----LAD 2487
+AQ DN+++M++DL ++Y LRI A K +++E L
Sbjct: 859 FTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQ 918
Query: 2488 PEISKNAFER---TLLMEERTMMMRDLQKVSGGGMSLSLPPA------------------ 2604
++KN ER ++ E R + R + + + L++P
Sbjct: 919 MHLTKNEREREIQSITDESRGSIRR--KNPANTRLRLNVPEETACDNEEKPEEEVQLIHD 976
Query: 2605 -NAPRAPSPLVT------SERRANSKXXXXXXXXXXXXXXXXXXXXXXXXQANQETKTKK 2763
+AP PS + E + + + ++ + K
Sbjct: 977 QSAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSAAQKNKGPSPVSSEGIKDFFSMK 1036
Query: 2764 ERMKALDRSKVSKMHTAVRLNELLLQHSANSQLILLNLPKPPVHKDQQALDDYVHYLEVM 2943
+ L++S V +MHTAVRLNE+++ S +++L+LLN+P PP +++ ++Y+ +LEV+
Sbjct: 1037 PEWENLNQSNVRRMHTAVRLNEVIVNKSRDAKLVLLNMPGPP--RNRNGDENYMEFLEVL 1094
Query: 2944 TDKLNRVIFVRGTGKEVIT 3000
T++L+RV+ VRG G+EVIT
Sbjct: 1095 TEQLDRVMLVRGGGREVIT 1113
>gi|47223173|emb|CAG11308.1| unnamed protein product [Tetraodon
nigroviridis]
Length = 1079
Score = 681 bits (1756), Expect = 0.0
Identities = 404/1013 (39%), Positives = 570/1013 (55%), Gaps = 67/1013 (6%)
Frame = +1
Query: 52 ERAQSSSHGGHGAKA-----DLGVLLGVYLPTIQHILGVTMFIRLFWLVGIAGLGQXXXX 216
E A++S G +K LG L+GVYLP IQ+I GV +F+R+ W+VGI G+
Sbjct: 65 EEAENSEEGPRPSKKPVKAPQLGTLMGVYLPCIQNIFGVILFLRMTWMVGIGGVFGSFII 124
Query: 217 XXXXXXXXXXXXISISAVATNGVV----------------------------ESGGAYFM 312
IS+SA+ATNGVV +GG+Y+M
Sbjct: 125 VFMCCSTTMLTAISMSAIATNGVVPGEKACKGCKASSDRLIDSCFLIPALWSAAGGSYYM 184
Query: 313 ISRNLGPEFGSAVGILFYLANTVATSMYLVGGVEILLLYIFPGLTFGGVEGQHDTSMFGT 492
ISR+LGPEFG AVGI FYL T A +MY++G +EILL+YI P +EG
Sbjct: 185 ISRSLGPEFGGAVGICFYLGTTFAGAMYILGCIEILLIYIVPQAAIFKIEGLEGPEAEVA 244
Query: 493 MTNSLRFYSTILLLIEFAIVAMGVKFVQMLAPVSLVCVILSILACYAGGVTKTIYPDSGQ 672
+ N++R Y TI+L +V +GVK+V LA V L CVILSI+A YA GV KT
Sbjct: 245 LLNNMRVYGTIVLSFMALVVFVGVKYVNKLALVFLACVILSIVAVYA-GVIKTAVDPPVF 303
Query: 673 YVCMYNDRLLQSSA--VLNESIPLDEICNYCNINNTFLADRVCGGRCNSTTIPHVSPFRC 846
VC+ +R L S V + + +D + +F C+ + +
Sbjct: 304 PVCILGNRTLVSKGYDVCAKVVEIDNETVTTKLWRSFCDSEYLNATCDQYFMD--NNVTE 361
Query: 847 INGFPGFQGGQTLLENLGPNYLEKGE--AAHGTQADTKSD---------VYQDVRTSFFV 993
I G PG G L ENL YLEKG G +D D V D+ + F +
Sbjct: 362 IQGIPGVTSG-ILAENLFGKYLEKGAILEKRGLPSDVDPDSPATSSNRYVLADITSFFTL 420
Query: 994 LLAIYFPAVTGIFTGANMSGDLKNPQASIPAGTIAANLTTSFVYFSLAFIFGGAIDNAVL 1173
L+ IYFP+VTGI G+N SGDL++ Q SIP GTIAA TTS VY S +FG I+ VL
Sbjct: 421 LVGIYFPSVTGIMAGSNRSGDLRDAQKSIPIGTIAAITTTSTVYMSCVVLFGACIEGVVL 480
Query: 1174 RDKNGQSVGGQMVVALLSWPSPWVLLIGSFLSTFGAALQCLCSAPRLLQAIAKDEVIPLL 1353
RDK G+ V G +V+ L+WPSPWV++ GSF ST GA LQ L APRLLQAI++D +IP L
Sbjct: 481 RDKFGEGVNGNLVIGTLAWPSPWVIVFGSFFSTCGAGLQSLTGAPRLLQAISRDGIIPFL 540
Query: 1354 SPFKKVTANNEPFXXXXXXXXXXXXXXXMGSMDTIAAVVDFFFLMCYAFVNIICTLHSLL 1533
F AN EP + S+D++A ++ FFLMCY FVN+ C L +LL
Sbjct: 541 RVFGHGKANGEPTWALLLTAGICEIGIIIASLDSVAPILSMFFLMCYMFVNLACALQTLL 600
Query: 1534 GAPNWRPRFKYYHWFLSLLGAVLCFFIMFSTHWDYAIVACLLCLVIYKYVEWKGAKKEWG 1713
PNWRPRFK+YHW LS+LG LC +MF W YAIVA + IYKY+E+ GA+KEWG
Sbjct: 601 RTPNWRPRFKFYHWALSVLGMSLCLSLMFICSWYYAIVAMGIATCIYKYIEFCGAEKEWG 660
Query: 1714 DGIRGLALTTAQYSLMKIEDKEPHPKNWRPQLLLLLSMQWSKEIIDVRYLNLLNLASQLK 1893
DGIRGL+L+ A ++LM++E+ PH KNWRPQ+L+L+S+ + + R LL+L +QLK
Sbjct: 661 DGIRGLSLSAAHFALMRLEEGPPHTKNWRPQILVLVSVDEEQNVEQPR---LLSLTNQLK 717
Query: 1894 AGKGLTVVTAFLQGDPTSPDDKKKGEQVKARMDFDMNQVRLRGFAKTLVHSEDQVRGSMS 2073
AGKGLT+V ++G T D + ++ + M R++GF + +V S +R S
Sbjct: 718 AGKGLTIVGTSVEG--TFLDSYTEAQRADQSLRKLMEAERVKGFPQVVVSS--NLRDGTS 773
Query: 2074 TLVQSVGLGGLKPNTMLISWPVHERE-EDMTEYNTFIEKVHAASINDMAIVVAKGIIDFP 2250
L+Q+ GLGGLK NT+++SWP + R+ E ++ FIE V ++ MA++V K I +P
Sbjct: 774 HLIQAGGLGGLKHNTVMVSWPHNWRQPEHHQQFRNFIEVVRETTVASMALLVPKNISSYP 833
Query: 2251 SAVFRMS-GMIDVYWIVHDGGLCLLMGYLLKQHKVWRGCKLRVIGIAQESDNNVKMQEDL 2427
S R + G +DV+WIVHDGG+ +L+ +LL+QHKVWR CK+R+ +AQ DN+++M++DL
Sbjct: 834 SNGERFTEGHMDVWWIVHDGGMLMLLPFLLRQHKVWRKCKMRIFTVAQMDDNSIQMKKDL 893
Query: 2428 QKYVYQLRIDAKIMIVELADPEISKNAFERTLLMEERTMMM-----------RDLQKVSG 2574
++Y LRIDA++ +VE+ D +IS +E+TL+ME+R+ M+ R++Q ++
Sbjct: 894 LTFLYHLRIDAQVEVVEMHDTDISAYTYEKTLVMEQRSQMLKQMHLTKNEMEREIQSITD 953
Query: 2575 GGM-SLSLPPANAPRAPSPLVT-SERRANSKXXXXXXXXXXXXXXXXXXXXXXXXQANQE 2748
S+ + P + +ER N +
Sbjct: 954 SSRGSIRRKTTSGPLYQDSMKEGAERPGNESLAVSDPKQVKLIHSKNASSPTSPIGPTKG 1013
Query: 2749 TKTKKE------RMKALDRSKVSKMHTAVRLNELLLQHSANSQLILLNLPKPP 2889
+ K E MK ++ V +MHTAVRLNE++++ S ++L+LLN+P PP
Sbjct: 1014 SAPKLEVGKDPFNMKP-NQVDVRRMHTAVRLNEVIIKKSKEAKLVLLNMPGPP 1065
>gi|50753670|ref|XP_414082.1| PREDICTED: similar to K-Cl cotransporter
[Gallus gallus]
Length = 1056
Score = 679 bits (1751), Expect = 0.0
Identities = 379/871 (43%), Positives = 535/871 (60%), Gaps = 27/871 (3%)
Frame = +1
Query: 31 HITPGPLERAQSSSHGGHGAKAD----LGVLLGVYLPTIQHILGVTMFIRLFWLVGIAGL 198
++T G E ++ S G K +G L+GVYLP +Q+I GV +F+RL W+VG+AG+
Sbjct: 144 NLTQGVKEHEEAESTDGSKKKVSKSPSMGTLMGVYLPCMQNIFGVILFLRLTWMVGMAGV 203
Query: 199 GQXXXXXXXXXXXXXXXXISISAVATNGVVESGGAYFMISRNLGPEFGSAVGILFYLANT 378
Q IS+SA+ATNGVV +GG+YFMISR+LGPEFG AVG+ FYL T
Sbjct: 204 LQSFLIVLLCCCCTMLTTISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTT 263
Query: 379 VATSMYLVGGVEILLLYIFPGLTFGGVEGQHDTSMFGTMTNSLRFYSTILLLIEFAIVAM 558
A +MY++G +EILL YI P G HD S M N++R Y T+ L++ +V +
Sbjct: 264 FAGAMYILGAIEILLTYIVPQAAIFYPSGAHDAS--SAMLNNMRVYGTVFLILMAVVVFV 321
Query: 559 GVKFVQMLAPVSLVCVILSILACYAGGVTKTIYPDSGQYVCMYNDRLL--QSSAVLNESI 732
GVK+V A + L CV++SIL+ YAG + K+I+ +CM +R L V ++I
Sbjct: 322 GVKYVNKFASLFLACVVISILSIYAGAI-KSIFDPPEFPICMLGNRTLIRDQFDVCAKTI 380
Query: 733 PLDEIC-------NYCNINNTFLADRVCGGRCNSTTIPHVSPFRCINGFPGFQGGQTLLE 891
D I N+C+ NT L C + ++ G PG G L +
Sbjct: 381 VKDNITVASKLWENFCH--NTNLTTENCDEYFLLNNVTEIA------GIPGAASG-ILKD 431
Query: 892 NLGPNYLEKGEA---AHGTQADTKSD-------VYQDVRTSFFVLLAIYFPAVTGIFTGA 1041
NL NYLEKGE AH D V D+ TSF VL+ I+FP+VTGI G+
Sbjct: 432 NLWSNYLEKGEVLEKAHHPSVDVAGQKSNFHLYVLSDISTSFMVLVGIFFPSVTGIMAGS 491
Query: 1042 NMSGDLKNPQASIPAGTIAANLTTSFVYFSLAFIFGGAIDNAVLRDKNGQSVGGQMVVAL 1221
N SGDLK+ Q SIP GTI A +TTS + L F +L ++ G +V +VV
Sbjct: 492 NRSGDLKDAQKSIPVGTILAIVTTSLM--KLVFTC------KLLPERYGDAVNKNLVVGT 543
Query: 1222 LSWPSPWVLLIGSFLSTFGAALQCLCSAPRLLQAIAKDEVIPLLSPFKKVTANNEPFXXX 1401
LSWPSPWV++IGSF ST GA LQ L APRLLQAIAKD +IP L F AN EP
Sbjct: 544 LSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLWVFGHGKANGEPTWAL 603
Query: 1402 XXXXXXXXXXXXMGSMDTIAAVVDFFFLMCYAFVNIICTLHSLLGAPNWRPRFKYYHWFL 1581
+ S+D +A ++ FFLMCY FVN+ C + +LL PNWRPRFKYYHW L
Sbjct: 604 LLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWAL 663
Query: 1582 SLLGAVLCFFIMFSTHWDYAIVACLLCLVIYKYVEWKGAKKEWGDGIRGLALTTAQYSLM 1761
S LG +C +MF + W YA+VA L+ +IYKY+E++GA+KEWGDGIRGL+L+ A+Y+L+
Sbjct: 664 SFLGMSICLALMFISSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALL 723
Query: 1762 KIEDKEPHPKNWRPQLLLLLSMQWSKEIIDVRYLNLLNLASQLKAGKGLTVVTAFLQGD- 1938
++E+ PH KNWRPQLL+LL + E + V+Y LL ASQLKAGKGLT++ + +QG+
Sbjct: 724 RLEEGPPHTKNWRPQLLVLLKLD---EDLHVKYPRLLTFASQLKAGKGLTIIGSVIQGNF 780
Query: 1939 -PTSPDDKKKGEQVKARMDFDMNQVRLRGFAKTLVHSEDQVRGSMSTLVQSVGLGGLKPN 2115
T + + + +K MD + +++GF + +V ++VR ++ L+QS GLGG+K N
Sbjct: 781 LETYGEAQAAEQTIKNMMDIE----KVKGFCQVVV--ANKVREGIAHLIQSCGLGGMKHN 834
Query: 2116 TMLISWPVHERE-EDMTEYNTFIEKVHAASINDMAIVVAKGIIDFPSAVFRMS-GMIDVY 2289
T+++ WP R+ ED + TFI V + +A++V K + +PS R + G IDV+
Sbjct: 835 TVVLGWPYGWRQSEDPRSWKTFIGTVRCTTAAHLALLVPKNVSFYPSNHERYNEGNIDVW 894
Query: 2290 WIVHDGGLCLLMGYLLKQHKVWRGCKLRVIGIAQESDNNVKMQEDLQKYVYQLRIDAKIM 2469
WIVHDGG+ +L+ +LLKQHKVWR CK+R+ +AQ DN+++M++DL ++YQLRI+A++
Sbjct: 895 WIVHDGGMLMLLPFLLKQHKVWRKCKMRIFTVAQMDDNSIQMKKDLATFLYQLRIEAEVE 954
Query: 2470 IVELADPEISKNAFERTLLMEERTMMMRDLQ 2562
+VE+ + +IS +ERTL+ME+R+ M+R ++
Sbjct: 955 VVEMHNSDISAYTYERTLMMEQRSQMLRQMR 985
>gi|27151688|sp|Q9H2X9|S125_HUMAN Solute carrier family 12 member 5
(Electroneutral potassium-chloride cotransporter 2)
(Erythroid K-Cl cotransporter 2) (Neuronal K-Cl
cotransporter) (hKCC2)
gi|12003227|gb|AAG43493.1| electroneutral potassium-chloride
cotransporter KCC2 [Homo sapiens]
Length = 1116
Score = 673 bits (1736), Expect = 0.0
Identities = 398/1041 (38%), Positives = 583/1041 (55%), Gaps = 74/1041 (7%)
Frame = +1
Query: 100 LGVLLGVYLPTIQHILGVTMFIRLFWLVGIAGLGQXXXXXXXXXXXXXXXXISISAVATN 279
+G +GVYLP +Q+I GV +F+RL W+VGIAG+ + IS+SA+ATN
Sbjct: 97 MGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATN 156
Query: 280 GVVESGGAYFMISRNLGPEFGSAVGILFYLANTVATSMYLVGGVEILLLYIFPGLTFGGV 459
GVV +GG+Y+MISR+LGPEFG AVG+ FYL T A +MY++G +EILL Y+FP +
Sbjct: 157 GVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKA 216
Query: 460 EGQHDTSMFGTMTNSLRFYSTILLLIEFAIVAMGVKFVQMLAPVSLVCVILSILACYAGG 639
E + M N++R Y T +L +V +GVK+V A V L CVILSILA YAG
Sbjct: 217 EDASGEA--AAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAG- 273
Query: 640 VTKTIYPDSGQYVCMYNDRLLQSSAVLNESIPLDEICNYCNINNTFLADRVCGGRCNSTT 819
V K+ + +C+ +R L D N + R+ G C+S
Sbjct: 274 VIKSAFDPPNFPICLLGNRTLSRHG-------FDVCAKLAWEGNETVTTRLWGLFCSSRF 326
Query: 820 IPHV-------SPFRCINGFPGFQGGQTLLENLGPNYLEKGEA-----------AHGTQA 945
+ + I G PG G + ENL +YL KG A GT
Sbjct: 327 LNATCDEYFTRNNVTEIQGIPGAASG-LIKENLWSSYLTKGVIVERSGMTSVGLADGTPI 385
Query: 946 DTKSD-VYQDVRTSFFVLLAIYFPAVTGIFTGANMSGDLKNPQASIPAGTIAANLTTSFV 1122
D V+ D+ + F +L+ IYFP+VTGI G+N SGDL++ Q SIP GTI A TTS V
Sbjct: 386 DMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAV 445
Query: 1123 YFSLAFIFGGAIDNAVLRDKNGQSVGGQMVVALLSWPSPWVLLIGSFLSTFGAALQCLCS 1302
Y S +FG I+ VLRDK G++V G +VV L+WPSPWV++IGSF ST GA LQ L
Sbjct: 446 YISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTG 505
Query: 1303 APRLLQAIAKDEVIPLLSPFKKVTANNEPFXXXXXXXXXXXXXXXMGSMDTIAAVVDFFF 1482
APRLLQAI++D ++P L F AN EP + S+D +A ++ FF
Sbjct: 506 APRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFF 565
Query: 1483 LMCYAFVNIICTLHSLLGAPNWRPRFKYYHWFLSLLGAVLCFFIMFSTHWDYAIVACLLC 1662
LMCY FVN+ C + +LL PNWRPRF+YYHW LS LG LC +MF W YA+VA L+
Sbjct: 566 LMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIA 625
Query: 1663 LVIYKYVEWKGAKKEWGDGIRGLALTTAQYSLMKIEDKEPHPKNWRPQLLLLLSMQWSKE 1842
+IYKY+E++GA+KEWGDGIRGL+L+ A+Y+L+++E+ PH KNWRPQLL+L+ + +
Sbjct: 626 GLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQN 685
Query: 1843 IIDVRYLNLLNLASQLKAGKGLTVVTAFLQGD--PTSPDDKKKGEQVKARMDFDMNQVRL 2016
++ + LL+L SQLKAGKGLT+V + L+G P ++ E ++ M+ + ++
Sbjct: 686 VV---HPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAE----KV 738
Query: 2017 RGFAKTLVHSEDQVRGSMSTLVQSVGLGGLKPNTMLISWPVHERE-EDMTEYNTFIEKVH 2193
+GF + ++ S +R +S L+QS GLGGL+ NT+L+ WP + R+ ED + FIE V
Sbjct: 739 KGFCQVVISSN--LRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVR 796
Query: 2194 AASINDMAIVVAKGIIDFPSAVFRMS-GMIDVYWIVHDGGLCLLMGYLLKQHKVWRGCKL 2370
+ +A++V K + FP R S G IDV+WIVHDGG+ +L+ +LL+ HKVWR CK+
Sbjct: 797 ETTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKM 856
Query: 2371 RVIGIAQESDNNVKMQE-----------------------DLQKYVYQLRIDAKIMIVEL 2481
R+ +AQ DN+++M++ D+ Y Y+ + + L
Sbjct: 857 RIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQIL 916
Query: 2482 ADPEISKNAFER---TLLMEERTMMMRDLQKVSGGGMSLSLPPA---------------- 2604
++KN ER ++ E R + R + + + L++P
Sbjct: 917 KQMHLTKNEREREIQSITDESRGSIRR--KNPANTRLRLNVPEETAGDSEEKPEEEVQLI 974
Query: 2605 ---NAPRAPSPLVT------SERRANSKXXXXXXXXXXXXXXXXXXXXXXXXQANQETKT 2757
+AP PS + E + + + ++ +
Sbjct: 975 HDQSAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFS 1034
Query: 2758 KKERMKALDRSKVSKMHTAVRLNELLLQHSANSQLILLNLPKPPVHKDQQALDDYVHYLE 2937
K + L++S V +MHTAVRLNE++++ S +++L+LLN+P PP +++ ++Y+ +LE
Sbjct: 1035 MKPEWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPP--RNRNGDENYMEFLE 1092
Query: 2938 VMTDKLNRVIFVRGTGKEVIT 3000
V+T+ L+RV+ VRG G+EVIT
Sbjct: 1093 VLTEHLDRVMLVRGGGREVIT 1113
>gi|11968148|ref|NP_065759.1| solute carrier family 12 member 5;
erythroid K-Cl cotransporter 2; neuronal K-Cl
cotransporter; electroneural potassium-chloride
cotransporter 2 [Homo sapiens]
gi|10443049|emb|CAC10460.1| bA465L10.5 (solute carrier family 12,
(potassium-chloride transporter) member 5 (KIAA1176))
[Homo sapiens]
Length = 1116
Score = 673 bits (1736), Expect = 0.0
Identities = 398/1041 (38%), Positives = 583/1041 (55%), Gaps = 74/1041 (7%)
Frame = +1
Query: 100 LGVLLGVYLPTIQHILGVTMFIRLFWLVGIAGLGQXXXXXXXXXXXXXXXXISISAVATN 279
+G +GVYLP +Q+I GV +F+RL W+VGIAG+ + IS+SA+ATN
Sbjct: 97 MGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATN 156
Query: 280 GVVESGGAYFMISRNLGPEFGSAVGILFYLANTVATSMYLVGGVEILLLYIFPGLTFGGV 459
GVV +GG+Y+MISR+LGPEFG AVG+ FYL T A +MY++G +EILL Y+FP +
Sbjct: 157 GVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKA 216
Query: 460 EGQHDTSMFGTMTNSLRFYSTILLLIEFAIVAMGVKFVQMLAPVSLVCVILSILACYAGG 639
E + M N++R Y T +L +V +GVK+V A V L CVILSILA YAG
Sbjct: 217 EDASGEA--AAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAG- 273
Query: 640 VTKTIYPDSGQYVCMYNDRLLQSSAVLNESIPLDEICNYCNINNTFLADRVCGGRCNSTT 819
V K+ + +C+ +R L D N + R+ G C+S
Sbjct: 274 VIKSAFDPPNFPICLLGNRTLSRHG-------FDVCAKLAWEGNETVTTRLWGLFCSSRF 326
Query: 820 IPHV-------SPFRCINGFPGFQGGQTLLENLGPNYLEKGEA-----------AHGTQA 945
+ + I G PG G + ENL +YL KG A GT
Sbjct: 327 LNATCDEYFTRNNVTEIQGIPGAASG-LIKENLWSSYLTKGVIVERSGMTSVGLADGTPI 385
Query: 946 DTKSD-VYQDVRTSFFVLLAIYFPAVTGIFTGANMSGDLKNPQASIPAGTIAANLTTSFV 1122
D V+ D+ + F +L+ IYFP+VTGI G+N SGDL++ Q SIP GTI A TTS V
Sbjct: 386 DMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAV 445
Query: 1123 YFSLAFIFGGAIDNAVLRDKNGQSVGGQMVVALLSWPSPWVLLIGSFLSTFGAALQCLCS 1302
Y S +FG I+ VLRDK G++V G +VV L+WPSPWV++IGSF ST GA LQ L
Sbjct: 446 YISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTG 505
Query: 1303 APRLLQAIAKDEVIPLLSPFKKVTANNEPFXXXXXXXXXXXXXXXMGSMDTIAAVVDFFF 1482
APRLLQAI++D ++P L F AN EP + S+D +A ++ FF
Sbjct: 506 APRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFF 565
Query: 1483 LMCYAFVNIICTLHSLLGAPNWRPRFKYYHWFLSLLGAVLCFFIMFSTHWDYAIVACLLC 1662
LMCY FVN+ C + +LL PNWRPRF+YYHW LS LG LC +MF W YA+VA L+
Sbjct: 566 LMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIA 625
Query: 1663 LVIYKYVEWKGAKKEWGDGIRGLALTTAQYSLMKIEDKEPHPKNWRPQLLLLLSMQWSKE 1842
+IYKY+E++GA+KEWGDGIRGL+L+ A+Y+L+++E+ PH KNWRPQLL+L+ + +
Sbjct: 626 GLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQN 685
Query: 1843 IIDVRYLNLLNLASQLKAGKGLTVVTAFLQGD--PTSPDDKKKGEQVKARMDFDMNQVRL 2016
++ + LL+L SQLKAGKGLT+V + L+G P ++ E ++ M+ + ++
Sbjct: 686 VV---HPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAE----KV 738
Query: 2017 RGFAKTLVHSEDQVRGSMSTLVQSVGLGGLKPNTMLISWPVHERE-EDMTEYNTFIEKVH 2193
+GF + ++ S +R +S L+QS GLGGL+ NT+L+ WP + R+ ED + FIE V
Sbjct: 739 KGFCQVVISSN--LRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVR 796
Query: 2194 AASINDMAIVVAKGIIDFPSAVFRMS-GMIDVYWIVHDGGLCLLMGYLLKQHKVWRGCKL 2370
+ +A++V K + FP R S G IDV+WIVHDGG+ +L+ +LL+ HKVWR CK+
Sbjct: 797 ETTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKM 856
Query: 2371 RVIGIAQESDNNVKMQE-----------------------DLQKYVYQLRIDAKIMIVEL 2481
R+ +AQ DN+++M++ D+ Y Y+ + + L
Sbjct: 857 RIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQIL 916
Query: 2482 ADPEISKNAFER---TLLMEERTMMMRDLQKVSGGGMSLSLPPA---------------- 2604
++KN ER ++ E R + R + + + L++P
Sbjct: 917 KQMHLTKNEREREIQSITDESRGSIRR--KNPANTRLRLNVPEETAGDSEEKPEEEVQLI 974
Query: 2605 ---NAPRAPSPLVT------SERRANSKXXXXXXXXXXXXXXXXXXXXXXXXQANQETKT 2757
+AP PS + E + + + ++ +
Sbjct: 975 HDQSAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFS 1034
Query: 2758 KKERMKALDRSKVSKMHTAVRLNELLLQHSANSQLILLNLPKPPVHKDQQALDDYVHYLE 2937
K + L++S V +MHTAVRLNE++++ S +++L+LLN+P PP +++ ++Y+ +LE
Sbjct: 1035 MKPEWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPP--RNRNGDENYMEFLE 1092
Query: 2938 VMTDKLNRVIFVRGTGKEVIT 3000
V+T+ L+RV+ VRG G+EVIT
Sbjct: 1093 VLTEHLDRVMLVRGGGREVIT 1113
>gi|25149428|ref|NP_500910.2| solute carrier family 12 member,
possibly N-myristoylated (4G837) [Caenorhabditis elegans]
gi|16950437|gb|AAF39883.2| Hypothetical protein H16O14.1
[Caenorhabditis elegans]
Length = 977
Score = 672 bits (1734), Expect = 0.0
Identities = 382/1003 (38%), Positives = 568/1003 (56%), Gaps = 36/1003 (3%)
Frame = +1
Query: 100 LGVLLGVYLPTIQHILGVTMFIRLFWLVGIAGLGQXXXXXXXXXXXXXXXXISISAVATN 279
+G ++GV+LP +Q+I GV FIRL W++G AG+ Q IS+SA+ATN
Sbjct: 1 MGTIMGVFLPCLQNIFGVLFFIRLAWIIGTAGVFQAFFVVLTCVSVTFLTSISLSAIATN 60
Query: 280 GVVESGGAYFMISRNLGPEFGSAVGILFYLANTVATSMYLVGGVEILLLYIFPGLTFGGV 459
GVV SGG Y+MISRNLGPE G AVGILFYL T+A SMY+ G +EILLLYI+P
Sbjct: 61 GVVPSGGPYYMISRNLGPELGGAVGILFYLGTTIAASMYITGAIEILLLYIYP------- 113
Query: 460 EGQHDTSMFGTMTNSLRFYSTILLLIEFAIVAMGVKFVQMLAPVSLVCVILSILACYAGG 639
+F + ++ R T+LLLI IV GVKFV A ++ VIL IL+ G
Sbjct: 114 ----QAKLFDDIYHNFRVLGTVLLLILGLIVMAGVKFVNRCALPLVIVVILCILSAILGV 169
Query: 640 VTKTIYPDSGQYVCMYNDRLLQSSAVLNESIPLDEICN-------YCNINNT--FLADRV 792
+ DS ++ CM DR + S E + C +C+ N T DR+
Sbjct: 170 FVRYDGSDSLKF-CMVGDRPVDLSTYF-EKTQVQPNCTADGLQDLFCSTNGTCDHYYDRM 227
Query: 793 CGGRC-NSTTIPHVSPFRCINGFPGFQGGQTLLENLGPNYLEKGEAAHGTQADT------ 951
+ S+ +P + R I G +NL P YL GE + D
Sbjct: 228 KNIKVWKSSGMPAIREERAIKGI----ASGVFFDNLWPKYLRAGEVLSKDRKDKGDLNRG 283
Query: 952 --KSDVYQDVRTSFFVLLAIYFPAVTGIFTGANMSGDLKNPQASIPAGTIAANLTTSFVY 1125
S +Y + T+F +L+ ++FP+ TGI G+N SG+L++ SIP GT+AA +SF+Y
Sbjct: 284 GHPSYIYAESVTNFMILVGVFFPSATGIMAGSNRSGNLRDAAKSIPLGTLAAQNFSSFIY 343
Query: 1126 FSLAFIFGGAIDNAVLRDKNGQSVGGQMVVALLSWPSPWVLLIGSFLSTFGAALQCLCSA 1305
+FG ++ +RDK G+S G+++++ +SWP P V+L G F+ST GA +Q L A
Sbjct: 344 LLGVVLFGASVSEMFIRDKYGRSAMGKLIISEISWPFPQVILFGCFMSTAGAGMQSLTGA 403
Query: 1306 PRLLQAIAKDEVIPLLSPFKKVTANNEPFXXXXXXXXXXXXXXXMGSMDTIAAVVDFFFL 1485
PRLLQAIA D+V+P L PF+K+ + EP + ++ I A++ FFL
Sbjct: 404 PRLLQAIAADDVLPFLKPFRKMDSRGEPIRAILLTLAICECGILIAVIENITALITQFFL 463
Query: 1486 MCYAFVNIICTLHSLLGAPNWRPRFKYYHWFLSLLGAVLCFFIMFSTHWDYAIVACLLCL 1665
MCY VN C L SLL +P WRP F+Y+HW LS++GA+LC +MF + W +A+ A ++
Sbjct: 464 MCYLGVNAACALQSLLKSPGWRPGFRYFHWSLSMIGAILCVAVMFISAWHFALFAIIIGA 523
Query: 1666 VIYKYVEWKGAKKEWGDGIRGLALTTAQYSLMKIEDKEPHPKNWRPQLLLLLSMQWSKEI 1845
+YKY+E+ GA+KEWGDG+RGL L+ A+++L+ ++DK H +NWRPQLL+L + ++
Sbjct: 524 GVYKYIEYAGAEKEWGDGLRGLGLSAARFALLNLDDKPQHSRNWRPQLLVL-----APDV 578
Query: 1846 IDVRYLNLLNLASQLKAGKGLTVVTAFLQGDPTSPDDKKKGEQVKARMDFDMNQVRLRGF 2025
+L+ SQLKAGKGLT+V ++G+ D+ K + V+ ++ + + +++GF
Sbjct: 579 ESANTNGILSFVSQLKAGKGLTLVAHCMEGEYA--DNYLKAQAVQEKLKAVVKKNKIKGF 636
Query: 2026 AKTLVHSEDQVRGSMSTLVQSVGLGGLKPNTMLISWPVH-EREEDMTEYNTFIEKVHAAS 2202
LV S V +S LVQ+ GLGG++ NT+++SWP + E++ N F+ + A S
Sbjct: 637 CDVLVTSN--VIEGISCLVQTSGLGGMRHNTVVLSWPNDWKAEQEWVVANKFVSAIRAIS 694
Query: 2203 INDMAIVVAKGIIDFPSAVFRMSGMIDVYWIVHDGGLCLLMGYLLKQHKVWRGCKLRVIG 2382
AI+V K FP+ ++SG IDV+W+VHDGGL +L+ +LL+QHK W+ +R+
Sbjct: 695 AAKCAIMVPKYAEKFPANGTKVSGFIDVWWVVHDGGLLMLLPFLLRQHKTWKNTTVRLFA 754
Query: 2383 IAQESDNNVKMQEDLQKYVYQLRIDAKIMIVELADPEISKNAFERTLLMEERTMMMRDLQ 2562
IAQ DNNV+M+ DL+K++Y LRIDA + ++E+ D +IS +ERT+ MEER +++L
Sbjct: 755 IAQMEDNNVQMKTDLEKFLYHLRIDAAVNVIEMTDSDISDYTYERTMKMEERNQYLKNLN 814
Query: 2563 K------------VSGGGMSLSL----PPANAPRAPSPLVTSERRANSKXXXXXXXXXXX 2694
K + LS PA P + V E + + K
Sbjct: 815 KSDRDKDIQNHLEIVTRERKLSRINEEAPAVVPEQRNLEVVDEEQEDGKSENGSAKIEHK 874
Query: 2695 XXXXXXXXXXXXXQANQETKTK-KERMKALDRSKVSKMHTAVRLNELLLQHSANSQLILL 2871
+ T + +E + R V KMHTAV+LNEL+ Q S+++QL+ +
Sbjct: 875 GVRFSDDEDSKEVKVGNGTLERDREERQRKRRYNVHKMHTAVKLNELMRQKSSDAQLVFV 934
Query: 2872 NLPKPPVHKDQQALDDYVHYLEVMTDKLNRVIFVRGTGKEVIT 3000
NLP PP D + Y+ ++E +T+ L+RV+ VRGTG EV+T
Sbjct: 935 NLPGPP---DADSDSYYMDFIEALTEGLDRVLLVRGTGAEVVT 974
>gi|47213000|emb|CAF95392.1| unnamed protein product [Tetraodon
nigroviridis]
Length = 1079
Score = 665 bits (1715), Expect = 0.0
Identities = 388/958 (40%), Positives = 558/958 (57%), Gaps = 28/958 (2%)
Frame = +1
Query: 100 LGVLLGVYLPTIQHILGVTMFIRLFWLVGIAGLGQXXXXXXXXXXXXXXXXISISAVATN 279
+G +GVYLP +Q++LGV +F+RL W+VG AG+ IS+ A+ATN
Sbjct: 77 MGTFIGVYLPCLQNVLGVILFLRLTWIVGTAGILGSFAIVSMCCICTLLTAISMCAIATN 136
Query: 280 GVVESGGAYFMISRNLGPEFGSAVGILFYLANTVATSMYLVGGVEILL------LYIFPG 441
GVV +GG+Y+MISR+LGPEFG AVG+ YL T A SMY++G +EILL +YI P
Sbjct: 137 GVVPAGGSYYMISRSLGPEFGGAVGVCLYLGTTFAGSMYILGTIEILLVGHRPEIYIVPT 196
Query: 442 LTFGGVEGQHDTSMFGTMTNSLRFYSTILLLIEFAIVAMGVKFVQMLAPVSLVCVILSIL 621
+ EG+ N++R Y T LL+ +V +GV++V LA V L CV+LSI+
Sbjct: 197 ASLFN-EGE---------ANNMRVYGTCCLLLMALVVFVGVRYVNKLALVFLACVVLSIM 246
Query: 622 ACYAGGVTKTIYPDSGQYVCMYNDRLLQSSAVLNESIPLDEICNYCNINNTFLADRVCGG 801
A YAG V KT+ VC+ +R +++ E+ ++ ++ T L D C G
Sbjct: 247 ATYAG-VIKTLIRPPEIKVCLVGNRTVRNDNF--ETCAKTQVVKNVSVT-TDLWDVFCPG 302
Query: 802 ---RC-NSTTIPHVSPFRCINGFPGFQGGQTLLENLGPNYLEKGEAAHGTQADTKSDV-- 963
C N + VS + I PG G + ENL Y G A + KS V
Sbjct: 303 LNATCDNYFLLNEVSELQAI---PGLLSG-VIRENLWGEY---GLAGKFIEKKNKSSVPV 355
Query: 964 ------------YQDVRTSFFVLLAIYFPAVTGIFTGANMSGDLKNPQASIPAGTIAANL 1107
D+ T F +L+ IYFP+VTGI G+N SGDL++ Q SIP GTI A L
Sbjct: 356 QEAALDDSQHYSINDISTYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQRSIPIGTIMAIL 415
Query: 1108 TTSFVYFSLAFIFGGAIDNAVLRDKNGQSVGGQMVVALLSWPSPWVLLIGSFLSTFGAAL 1287
TTSF+Y S FG I+ VLRDK G SV V+ +L+WPSPWV++IGSF S+ GA L
Sbjct: 416 TTSFIYISSVVFFGACIEGVVLRDKFGFSVKRSPVIGILAWPSPWVIVIGSFFSSCGAGL 475
Query: 1288 QCLCSAPRLLQAIAKDEVIPLLSPFKKVTANNEPFXXXXXXXXXXXXXXXMGSMDTIAAV 1467
Q L APRLLQAIA+D +IP L F + +N EP + S+DT+A +
Sbjct: 476 QSLTGAPRLLQAIARDGIIPFLQVFGQGKSNGEPTWGLLLTVGICEIGVLIASVDTVAPI 535
Query: 1468 VDFFFLMCYAFVNIICTLHSLLGAPNWRPRFKYYHWFLSLLGAVLCFFIMFSTHWDYAIV 1647
+ FFLMCY FVN+ C + +LL PNWRPRF++YHW LS LG LC +MF + W YA+V
Sbjct: 536 LSMFFLMCYLFVNLACAVQTLLRTPNWRPRFQFYHWTLSFLGMSLCLSLMFVSSWYYALV 595
Query: 1648 ACLLCLVIYKYVEWKGAKKEWGDGIRGLALTTAQYSLMKIEDKEPHPKNWRPQLLLLLSM 1827
+ ++ IYKY+E+KGA KEWGDGIRGL+L A+Y+L+++E+ H KNWRPQ+L+L +
Sbjct: 596 SIVIAGCIYKYIEYKGAVKEWGDGIRGLSLNAARYALIRLEEVPLHTKNWRPQVLVLCKL 655
Query: 1828 QWSKEIIDVRYLNLLNLASQLKAGKGLTVVTAFLQGDPTSPDDKKKG--EQVKARMDFDM 2001
+ V++ LL +QLKAGKGLT+V + L+G S K + +KA M +
Sbjct: 656 DSD---LQVKHPRLLTFTTQLKAGKGLTIVCSVLEGTFLSRGSHAKTAEQNLKAAMAAE- 711
Query: 2002 NQVRLRGFAKTLVHSEDQVRGSMSTLVQSVGLGGLKPNTMLISWPVH-EREEDMTEYNTF 2178
R +GF+ +V S +R S L+QS GLGG+K NT+L++WP ++ D + F
Sbjct: 712 ---RTKGFSHVVVTSN--LRDGFSLLIQSAGLGGMKHNTVLMAWPAGWTQDRDPSSRRNF 766
Query: 2179 IEKVHAASINDMAIVVAKGIIDFPSAVFRMS-GMIDVYWIVHDGGLCLLMGYLLKQHKVW 2355
IE V + A++VAK I FP R+ G +DV+WIVHDGGL +L+ +LLKQHKVW
Sbjct: 767 IETVRETTAAHQALLVAKNIDRFPGNQERLKEGTVDVWWIVHDGGLLMLLPFLLKQHKVW 826
Query: 2356 RGCKLRVIGIAQESDNNVKMQEDLQKYVYQLRIDAKIMIVELADPEISKNAFERTLLMEE 2535
R CK+R+ +AQ +DN+++M++DLQ ++Y LR++A++ +VE+ D +IS +E+TL+ME+
Sbjct: 827 RKCKMRIFTVAQMNDNSIQMKKDLQMFLYHLRLNAEVEVVEMHDSDISAFTYEKTLVMEQ 886
Query: 2536 RTMMMRDLQKVSGGGMSLSLPPANAPRAPSPLVTSERRANSKXXXXXXXXXXXXXXXXXX 2715
R+ M++ +Q +S + S +R A +
Sbjct: 887 RSQMLKQMQ-LSRTERKREAQLIHDRNTASHSAPGDRSAGTSQQEGVHMTWTKERLSQER 945
Query: 2716 XXXXXXQANQETKTKKERMKALDRSKVSKMHTAVRLNELLLQHSANSQLILLNLPKPP 2889
++ K + L++S V +MHTA+RLN+++++ S++SQL+LLN+P PP
Sbjct: 946 SRQREGLGVKDLFNMKPEWENLNQSNVRRMHTAIRLNKVVVEKSSHSQLVLLNMPGPP 1003
>gi|6330233|dbj|BAA86490.1| KIAA1176 protein [Homo sapiens]
Length = 1101
Score = 662 bits (1708), Expect = 0.0
Identities = 393/1037 (37%), Positives = 578/1037 (54%), Gaps = 74/1037 (7%)
Frame = +1
Query: 100 LGVLLGVYLPTIQHILGVTMFIRLFWLVGIAGLGQXXXXXXXXXXXXXXXXISISAVATN 279
+G +GVYLP +Q+I GV +F+RL W+VGIAG+ + IS+SA+ATN
Sbjct: 89 MGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATN 148
Query: 280 GVVESGGAYFMISRNLGPEFGSAVGILFYLANTVATSMYLVGGVEILLLYIFPGLTFGGV 459
GVV +GG+Y+MISR+LGPEFG AVG+ FYL T A +MY++G +EILL Y+FP +
Sbjct: 149 GVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKA 208
Query: 460 EGQHDTSMFGTMTNSLRFYSTILLLIEFAIVAMGVKFVQMLAPVSLVCVILSILACYAGG 639
E + M N++R Y T +L +V +GVK+V A V L CVILSILA YAG
Sbjct: 209 EDASGEA--AAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAG- 265
Query: 640 VTKTIYPDSGQYVCMYNDRLLQSSAVLNESIPLDEICNYCNINNTFLADRVCGGRCNSTT 819
V K+ + +C+ +R L D N + R+ G C+S
Sbjct: 266 VIKSAFDPPNFPICLLGNRTLSRHG-------FDVCAKLAWEGNETVTTRLWGLFCSSRF 318
Query: 820 IPHV-------SPFRCINGFPGFQGGQTLLENLGPNYLEKGEA-----------AHGTQA 945
+ + I G PG G + ENL +YL KG A GT
Sbjct: 319 LNATCDEYFTRNNVTEIQGIPGAASG-LIKENLWSSYLTKGVIVERSGMTSVGLADGTPI 377
Query: 946 DTKSD-VYQDVRTSFFVLLAIYFPAVTGIFTGANMSGDLKNPQASIPAGTIAANLTTSFV 1122
D V+ D+ + F +L+ IYFP+VTGI G+N SGDL++ Q SIP GTI A TTS V
Sbjct: 378 DMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAV 437
Query: 1123 YFSLAFIFGGAIDNAVLRDKNGQSVGGQMVVALLSWPSPWVLLIGSFLSTFGAALQCLCS 1302
Y S +FG I+ VLRDK G++V G +VV L+WPSPWV++IGSF ST GA LQ L
Sbjct: 438 YISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTG 497
Query: 1303 APRLLQAIAKDEVIPLLSPFKKVTANNEPFXXXXXXXXXXXXXXXMGSMDTIAAVVDFFF 1482
APRLLQAI++D ++P L F AN EP + S+D +A ++ FF
Sbjct: 498 APRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFF 557
Query: 1483 LMCYAFVNIICTLHSLLGAPNWRPRFKYYHWFLSLLGAVLCFFIMFSTHWDYAIVACLLC 1662
LMCY FVN+ C + +LL PNWRPRF+YYHW LS LG LC +MF W YA+VA L+
Sbjct: 558 LMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIA 617
Query: 1663 LVIYKYVEWKGAKKEWGDGIRGLALTTAQYSLMKIEDKEPHPKNWRPQLLLLLSMQWSKE 1842
+IYKY+E++GA+KEWGDGIRGL+L+ A+Y+L+++E+ PH KNWRPQLL+L+ + +
Sbjct: 618 GLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQN 677
Query: 1843 IIDVRYLNLLNLASQLKAGKGLTVVTAFLQGD--PTSPDDKKKGEQVKARMDFDMNQVRL 2016
++ + LL+L SQLKAGKGLT+V + L+G P ++ E ++ M+ + ++
Sbjct: 678 VV---HPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAE----KV 730
Query: 2017 RGFAKTLVHSEDQVRGSMSTLVQSVGLGGLKPNTMLISWPVHERE-EDMTEYNTFIEKVH 2193
+GF + ++ S +R +S L+QS GLGGL+ NT+L+ WP + R+ ED + FIE V
Sbjct: 731 KGFCQVVISSN--LRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVR 788
Query: 2194 AASINDMAIVVAKGIIDFPSAVFRMS-GMIDVYWIVHDGGLCLLMGYLLKQHKVWRGCKL 2370
+ +A++V K + FP R S G IDV+WIVHDGG+ +L+ +LL+ HKVWR CK+
Sbjct: 789 ETTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKM 848
Query: 2371 RVIGIAQESDNNVKMQE-----------------------DLQKYVYQLRIDAKIMIVEL 2481
R+ +AQ DN+++M++ D+ Y Y+ + + L
Sbjct: 849 RIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQIL 908
Query: 2482 ADPEISKNAFER---TLLMEERTMMMRDLQKVSGGGMSLSLPPA---------------- 2604
++KN ER ++ E R + R + + + L++P
Sbjct: 909 KQMHLTKNEREREIQSITDESRGSIRR--KNPANTRLRLNVPEETAGDSEEKPEEEVQLI 966
Query: 2605 ---NAPRAPSPLVT------SERRANSKXXXXXXXXXXXXXXXXXXXXXXXXQANQETKT 2757
+AP PS + E + + + ++ +
Sbjct: 967 HDQSAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFS 1026
Query: 2758 KKERMKALDRSKVSKMHTAVRLNELLLQHSANSQLILLNLPKPPVHKDQQALDDYVHYLE 2937
K + L++S V +MHTAVRLNE++++ S +++L+LLN+P P +++ ++Y+ +LE
Sbjct: 1027 MKPEWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGLP--RNRNGDENYMEFLE 1084
Query: 2938 VMTDKLNRVIFVRGTGK 2988
V+T+ L+RV+ VRG G+
Sbjct: 1085 VLTEHLDRVMLVRGGGR 1101
>gi|39584234|emb|CAE61609.1| Hypothetical protein CBG05529
[Caenorhabditis briggsae]
Length = 977
Score = 653 bits (1684), Expect = 0.0
Identities = 370/1003 (36%), Positives = 567/1003 (55%), Gaps = 36/1003 (3%)
Frame = +1
Query: 100 LGVLLGVYLPTIQHILGVTMFIRLFWLVGIAGLGQXXXXXXXXXXXXXXXXISISAVATN 279
+G ++GV+LP +Q+I GV FIRL W++G AG+ Q IS+SA+ATN
Sbjct: 1 MGTIMGVFLPCLQNIFGVLFFIRLAWIIGTAGIFQAFFVVLTCVSVTFLTSISLSAIATN 60
Query: 280 GVVESGGAYFMISRNLGPEFGSAVGILFYLANTVATSMYLVGGVEILLLYIFPGLTFGGV 459
GVV SGG Y+MISRNLGPE G AVGILFYL T+A SMY+ G +EILLLYI+P
Sbjct: 61 GVVPSGGPYYMISRNLGPELGGAVGILFYLGTTIAASMYITGAIEILLLYIYP------- 113
Query: 460 EGQHDTSMFGTMTNSLRFYSTILLLIEFAIVAMGVKFVQMLAPVSLVCVILSILACYAGG 639
+F + ++ R T+LL++ ++A GVKFV A ++ VI IL+ G
Sbjct: 114 ----QAKLFDDIYHNYRVLGTLLLILGLIVMA-GVKFVNRCALPLVIVVIFCILSAILGV 168
Query: 640 VTKTIYPDSGQYVCMYNDRLLQSSAVLNESIPLDEICN------YCNINNT--FLADRVC 795
+ DS ++ CM DR + ++ ++ + +C+ N T DR+
Sbjct: 169 FVRYDGSDSLKF-CMVGDRPVDLTSYYEKTKFVPNCTTEGLRDLFCSANGTCDHYYDRMK 227
Query: 796 GGRC-NSTTIPHVSPFRCINGFPGFQGGQTLLENLGPNYLEKGEAAHGTQADT------- 951
+ ++ +P + R I G +NL P YL GE + D
Sbjct: 228 DIKVWKASGMPAIREERAIKGI----ASGVFFDNLWPKYLRGGEVLSKDRKDKGDLNRGG 283
Query: 952 -KSDVYQDVRTSFFVLLAIYFPAVTGIFTGANMSGDLKNPQASIPAGTIAANLTTSFVYF 1128
S +Y + T+F +L+ ++FP+ TGI G+N SG+L++ SIP GT+AA +SF+Y
Sbjct: 284 HPSYIYAESVTNFMILVGVFFPSATGIMAGSNRSGNLRDAAKSIPLGTLAAQNFSSFIYL 343
Query: 1129 SLAFIFGGAIDNAVLRDKNGQSVGGQMVVALLSWPSPWVLLIGSFLSTFGAALQCLCSAP 1308
+FG ++ +RDK G+S G+++++ +SWP P V+L G F+ST GA +Q L AP
Sbjct: 344 LGVVLFGASVSEMFIRDKYGRSAMGKLIISEISWPFPQVILFGCFMSTAGAGMQSLTGAP 403
Query: 1309 RLLQAIAKDEVIPLLSPFKKVTANNEPFXXXXXXXXXXXXXXXMGSMDTIAAVVDFFFLM 1488
RLLQAIA D+VIP L PF+K+ + EP + ++ I A++ FFLM
Sbjct: 404 RLLQAIAADDVIPFLKPFRKMDSRGEPIRAILLTLAICECGILIAVIENITALITQFFLM 463
Query: 1489 CYAFVNIICTLHSLLGAPNWRPRFKYYHWFLSLLGAVLCFFIMFSTHWDYAIVACLLCLV 1668
CY VN C L SLL +P WRP F+Y+HW LS++GA+LC +MF + W +A++A ++
Sbjct: 464 CYLGVNAACALQSLLKSPGWRPGFRYFHWALSMIGAILCVAVMFISAWHFALIAIVIGAG 523
Query: 1669 IYKYVEWKGAKKEWGDGIRGLALTTAQYSLMKIEDKEPHPKNWRPQLLLLLSMQWSKEII 1848
+YKY+E+ GA+KEWGDG+RGL L+ A+++L+ ++DK H +NWRPQLL+L + ++
Sbjct: 524 VYKYIEYAGAEKEWGDGLRGLGLSAARFALLNLDDKPQHSRNWRPQLLVL-----APDVE 578
Query: 1849 DVRYLNLLNLASQLKAGKGLTVVTAFLQGDPTSPDDKKKGEQVKARMDFDMNQVRLRGFA 2028
+L+ SQLKAGKGLT+V ++G+ D+ + + V+ ++ + + +++GF
Sbjct: 579 SANTNGILSFVSQLKAGKGLTLVAHCMEGE--YADNYLQAQAVQEKLKAMVKKNKIKGFC 636
Query: 2029 KTLVHSEDQVRGSMSTLVQSVGLGGLKPNTMLISWPVHER-EEDMTEYNTFIEKVHAASI 2205
LV S V +S LVQ+ GLGG++ NT+++SWP R +++ N F+ + A S
Sbjct: 637 DVLVTS--NVIEGISCLVQTSGLGGMRHNTVVLSWPDDWRADQEWAVANKFVSAIRAISA 694
Query: 2206 NDMAIVVAKGIIDFPSAVFRMSGMIDVYWIVHDGGLCLLMGYLLKQHKVWRGCKLRVIGI 2385
AI+V K FP+ ++SG IDV+W+VHDGGL +L+ +LL+QHK W+ +R+ I
Sbjct: 695 AKCAIMVPKYAEKFPANGTKVSGYIDVWWVVHDGGLLMLLPFLLRQHKTWKNTTVRLFAI 754
Query: 2386 AQESDNNVKMQEDLQKYVYQLRIDAKIMIVELADPEISKNAFERTLLMEERTMMM----- 2550
AQ DNNV+M+ DL+K++Y LRIDA + ++E+ D +IS +ERT+ MEER +
Sbjct: 755 AQMEDNNVQMKTDLEKFLYHLRIDAAVNVIEMTDSDISDYTYERTMKMEERNQYLNLNKS 814
Query: 2551 ---RDLQ---KVSGGGMSLSLPPANAPRAPSPLVTSERRANSKXXXXXXXXXXXXXXXXX 2712
+D+Q ++ LS AP E +
Sbjct: 815 DREKDIQNHLEIVTRERKLSRINEEAPTVIPEQRNLEAVTEEQEQEEQKSEKSLEKLEHK 874
Query: 2713 XXXXXXXQANQETKT-------KKERMKALDRSKVSKMHTAVRLNELLLQHSANSQLILL 2871
+ +E K +E + R V KMHTAV+LNE++ Q S+++QL+ +
Sbjct: 875 GVRFSDDEDGKEVKVGNGTMERDREERQRKRRYNVHKMHTAVKLNEMMRQKSSDAQLVFI 934
Query: 2872 NLPKPPVHKDQQALDDYVHYLEVMTDKLNRVIFVRGTGKEVIT 3000
NLP PP D + Y+ +++ +T+ L+RV+ VRGTG EV+T
Sbjct: 935 NLPGPP---DADSDSYYMDFIDALTEGLDRVLLVRGTGAEVVT 974
>gi|47220725|emb|CAG11794.1| unnamed protein product [Tetraodon
nigroviridis]
Length = 1150
Score = 643 bits (1659), Expect = 0.0
Identities = 370/887 (41%), Positives = 513/887 (57%), Gaps = 67/887 (7%)
Frame = +1
Query: 100 LGVLLGVYLPTIQHILGVTMFIRLFWLVGIAGLGQXXXXXXXXXXXXXXXXISISAVATN 279
LG L+GVYLP IQ+I GV +F+R+ WLVGI G+ IS+SA+ATN
Sbjct: 84 LGTLMGVYLPCIQNIFGVILFLRMTWLVGIGGVIGTFIIVFMCCATTMLTAISMSAIATN 143
Query: 280 GVVESGGAYFMISRNLGPEFGSAVGILFYLANTVATSMYLVGGVEILLLYIFPGLTFGGV 459
GVV +GG+Y+MISR+LGPEFG AVGI FYL T A +MY++G +E+LL+YI P +
Sbjct: 144 GVVPAGGSYYMISRSLGPEFGGAVGICFYLGTTYAGAMYILGAIELLLIYIVPKAAIFPL 203
Query: 460 EGQHDTSMFGTMTNSLRFYSTILLLIEFAIVAMGVKFVQMLAPVSLVCVILSILACYAGG 639
EG + N++R Y TILL +V +GVK+V LA V L CVILSILA YAG
Sbjct: 204 EGLEGAEAEAALLNNMRVYGTILLTSMATVVFVGVKYVNKLALVFLACVILSILAVYAGV 263
Query: 640 VTKTIYPDSGQYVCMYNDRLL--QSSAVLNESIPLDEICNYCNINNTFLADRVCGGRCNS 813
+ + P VC+ +R L +S V +++ + F + C+
Sbjct: 264 IKTAVEPPVFP-VCVLGNRTLVWKSFDVCAKTMETANGTVTTQLWRMFCDSSLLNATCDK 322
Query: 814 TTIPHVSPFRCINGFPGFQGGQTLLENLGPNYLEKGEAAHGTQADTKSD----------- 960
I + I G PG G L ENL Y EKG+ + +
Sbjct: 323 YFIEN--NVTEIQGIPGVTSG-ILAENLFGTYYEKGDLIAKKDVPSVEEQDDPLTSANRY 379
Query: 961 VYQDVRTSFFVLLAIYFPAVTGIFTGANMSGDLKNPQASIPAGTIAANLTTSFVYFSLAF 1140
V D+ + F +L+ IYFP+VTGI G+N SGDL++ Q SIP GTIAA TTS VY S
Sbjct: 380 VLADITSFFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPIGTIAAITTTSTVYMSSVI 439
Query: 1141 IFGGAIDNAVLRDKNGQSVGGQMVVALLSWPSPWVLLIGSFLSTFGAALQCLCSAPRLLQ 1320
+FG I+ VLRDK G+ V G +V+ L+WPSPWV++IGSF ST GA LQ L APRLLQ
Sbjct: 440 LFGACIEGVVLRDKFGEGVHGNLVIGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQ 499
Query: 1321 AIAKDEVIPLLSPFKKVTANNEPFXXXXXXXXXXXXXXXMGSMDTIAAVVDFFFLMCYAF 1500
AIAKD ++P L F AN EP + S+D++A ++ FFLMCY F
Sbjct: 500 AIAKDGIVPALRIFGHGKANGEPTWSLLLTACICESGILIASLDSVAPILSMFFLMCYMF 559
Query: 1501 VNIICTLHSLLGAPNWRPRFKYYHWFLSLLGAVLCFFIMFSTHWDYAIVACLLCLVIYKY 1680
VN+ C L +LL PNWRPRFK+YHW LS LG LC +MF W YAIVA + IYKY
Sbjct: 560 VNLACALQTLLRTPNWRPRFKFYHWTLSFLGMSLCLTLMFLCSWYYAIVAMAIAGSIYKY 619
Query: 1681 VEWKGAKKEWGDGIRGLALTTAQYSLMKIEDKEPHPKNWRPQLLLLLSMQWSKEIIDVRY 1860
+E+ GA+KEWGDGIRGL+L+ A+Y+LM++E+ PH KNWRPQLL+L+S + + R
Sbjct: 620 IEFAGAEKEWGDGIRGLSLSAARYALMRLEEGPPHTKNWRPQLLVLVSTDAEQNVEQPR- 678
Query: 1861 LNLLNLASQLKAGKGLTVVTAFLQGDPTSPDDKKKGEQVKARMDFDMNQVRLRGFAKTLV 2040
LL+L SQLKAGKGLT+V L+G T D+ ++ ++ + + M +++GF++ V
Sbjct: 679 --LLSLTSQLKAGKGLTIVGTALEG--TYLDNYEQTQRAEQALRKLMETEKVKGFSQVTV 734
Query: 2041 HSEDQVRGSMSTLVQSVGLGGLKPNTMLISWPVHEREEDMTE-YNTFI------------ 2181
S +R + S L+Q+ GLGGLK N +L+SWP + ++ D + + F+
Sbjct: 735 SS--NLRDATSHLLQASGLGGLKHNAVLVSWPRNWKQGDEHQTWRNFVDCPEIPALASSS 792
Query: 2182 ----------EKVHAASINDMAIVVAKGIIDFPSAVFRMS-GMIDVYWIVHDGGLCLLMG 2328
E V + +A++V K I FPS R + G IDV+WIVHDGG+ +L+
Sbjct: 793 EAVKASLRNAELVRETTAAHLALLVPKNISAFPSNGERFTEGHIDVWWIVHDGGMLMLLP 852
Query: 2329 YLLKQHKVWRGCKLRVIGIAQESDNNVKMQEDLQKYVYQLRIDAKIMIVELADP------ 2490
+LL+QHKVWR CK+R+ +AQ DN+++M++DL ++Y LRIDA + +VE+ P
Sbjct: 853 FLLRQHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRIDAMVEVVEMVTPPLCLKL 912
Query: 2491 ------------------------EISKNAFERTLLMEERTMMMRDL 2559
+IS +E+TL+ME+R+ M++ +
Sbjct: 913 IGGAGRVQRTPHNKRAPPVSQHDGDISAYTYEKTLVMEQRSQMLKQI 959
Score = 77.8 bits (190), Expect = 1e-12
Identities = 36/73 (49%), Positives = 59/73 (80%)
Frame = +1
Query: 2782 DRSKVSKMHTAVRLNELLLQHSANSQLILLNLPKPPVHKDQQALDDYVHYLEVMTDKLNR 2961
++S V +MHTA+RLNE++L+ S+ ++L+LLN+P PP +++ ++Y+ +LEV+T+ LNR
Sbjct: 1077 NQSNVRRMHTALRLNEVILKKSSEAKLVLLNMPGPP--RNRTGDENYMEFLEVLTEGLNR 1134
Query: 2962 VIFVRGTGKEVIT 3000
V+ VRG G+EVIT
Sbjct: 1135 VLLVRGGGREVIT 1147