Homology by BLASTX
BLASTX 2.2.4 [Aug-26-2002]
Query= T21E8_3
(3678 letters)
Database: /home/niguts/usr02/tshini/ykclst/db/nr.seq
1,967,186 sequences; 661,712,633 total letters
Score E
Sequences producing significant alignments: (bits) Value
gi|17569907|ref|NP_509813.1| P-GlycoProtein related (pgp-6) [Cae... 2369 0.0
gi|50507726|emb|CAA94219.3| Hypothetical protein T21E8.2 [Caenor... 2269 0.0
gi|17569909|ref|NP_509812.1| P-GlycoProtein related (pgp-7) [Cae... 2263 0.0
gi|7508147|pir||T25083 hypothetical protein T21E8.1 - Caenorhabd... 2145 0.0
gi|39594939|emb|CAE70807.1| Hypothetical protein CBG17569 [Caeno... 2093 0.0
gi|7508148|pir||T25082 hypothetical protein T21E8.2 - Caenorhabd... 2044 0.0
gi|17550138|ref|NP_509810.1| P-GlycoProtein related (pgp-5) [Cae... 1609 0.0
gi|39594940|emb|CAE70808.1| Hypothetical protein CBG17570 [Caeno... 1513 0.0
gi|25146777|ref|NP_509811.2| P-GlycoProtein related (pgp-8) [Cae... 1505 0.0
gi|7511495|pir||T18940 multidrug resistance protein homolog - Ca... 1494 0.0
gi|39594943|emb|CAE70811.1| Hypothetical protein CBG17574 [Caeno... 1110 0.0
gi|39585393|emb|CAE61715.1| Hypothetical protein CBG05664 [Caeno... 895 0.0
gi|17558664|ref|NP_507487.1| P-GlycoProtein related (pgp-9) [Cae... 887 0.0
gi|17541710|ref|NP_502413.1| P-GlycoProtein related (pgp-1) [Cae... 832 0.0
gi|283551|pir||S27337 multidrug resistance protein A - Caenorhab... 831 0.0
gi|39587899|emb|CAE67917.1| Hypothetical protein CBG13514 [Caeno... 831 0.0
gi|39594783|emb|CAE70651.1| Hypothetical protein CBG17356 [Caeno... 778 0.0
gi|17569145|ref|NP_509902.1| P-GlycoProtein related (pgp-4) [Cae... 777 0.0
gi|1362689|pir||S55692 multidrug resistance protein homolog (mdr... 771 0.0
gi|833699|gb|AAA75000.1| multidrug resistance protein >gnl|BL_OR... 771 0.0
gi|45382457|ref|NP_990225.1| ABC transporter protein [Gallus gal... 770 0.0
gi|72477|pir||DVHY1C multidrug resistance protein 1 - Chinese ha... 769 0.0
gi|126924|sp|P21448|MDR1_CRIGR Multidrug resistance protein 1 (P... 769 0.0
gi|40644181|emb|CAC86600.1| multidrug resistance protein [Platic... 768 0.0
gi|25453402|ref|NP_596892.1| ATP-binding cassette, sub-family B ... 766 0.0
gi|39595370|emb|CAE60408.1| Hypothetical protein CBG04013 [Caeno... 766 0.0
gi|46394986|gb|AAS91649.1| multidrug resistance protein 1a; P-gl... 762 0.0
gi|6755048|ref|NP_035206.1| ATP-binding cassette, sub-family B (... 758 0.0
gi|266517|sp|P21447|MDR3_MOUSE Multidrug resistance protein 3 (P... 758 0.0
gi|17508505|ref|NP_491707.1| P-GlycoProtein related (pgp-2) [Cae... 758 0.0
gi|307180|gb|AAA59575.1| P-glycoprotein [Homo sapiens] 757 0.0
gi|2149087|gb|AAB58489.1| multidrug resistance protein-1 [Ovis a... 756 0.0
gi|2353264|gb|AAB69423.1| P-glycoprotein [Homo sapiens] 755 0.0
gi|42741659|ref|NP_000918.2| ATP-binding cassette sub-family B m... 755 0.0
gi|2506118|sp|P08183|MDR1_HUMAN Multidrug resistance protein 1 (... 754 0.0
gi|50732589|ref|XP_418707.1| PREDICTED: similar to ATP-binding c... 750 0.0
gi|25297453|pir||D87789 protein C34G6.4 [imported] - Caenorhabdi... 748 0.0
gi|25453370|ref|NP_036755.2| P-glycoprotein/multidrug resistance... 748 0.0
gi|38073917|ref|XP_283101.2| similar to multidrug resistance p-g... 748 0.0
gi|6755046|ref|NP_035205.1| ATP-binding cassette, sub-family B (... 747 0.0
gi|48267183|gb|AAQ63650.3| multi-drug resistance P-glycoprotein ... 744 0.0
gi|191157|gb|AAA37005.1| p-glycoprotein 744 0.0
gi|46394982|gb|AAS91647.1| multidrug resistance protein 1; P-gly... 744 0.0
gi|8926217|gb|AAF81747.1| his-tagged-multidrug resistance glycop... 743 0.0
gi|31442763|gb|AAN07780.2| multidrug resistance p-glycoprotein [... 743 0.0
gi|126928|sp|P21449|MDR2_CRIGR Multidrug resistance protein 2 (P... 743 0.0
gi|22775296|gb|AAN07779.1| multidrug resistance p-glycoprotein [... 743 0.0
gi|2852441|gb|AAC02113.1| multidrug resistance p-glycoprotein [C... 742 0.0
gi|22759019|gb|AAN05645.1| multidrug resistance p-glycoprotein [... 742 0.0
gi|46394984|gb|AAS91648.1| multidrug resistance protein; P-glyco... 740 0.0
gi|39594784|emb|CAE70652.1| Hypothetical protein CBG17357 [Caeno... 737 0.0
gi|1170902|sp|P43245|MDR1_RAT Multidrug resistance protein 1 (P-... 734 0.0
gi|17569143|ref|NP_509901.1| P-GlycoProtein related (pgp-3) [Cae... 733 0.0
gi|126930|sp|P23174|MDR3_CRIGR Multidrug resistance protein 3 (P... 733 0.0
gi|6679297|ref|NP_032856.1| ATP-binding cassette, sub-family B (... 732 0.0
gi|4505771|ref|NP_000434.1| ATP-binding cassette, subfamily B, m... 728 0.0
gi|7511698|pir||T31073 multidrug resistance p-glycoprotein - nem... 726 0.0
gi|6981354|ref|NP_036822.1| ATP-binding cassette, sub-family B (... 724 0.0
gi|27656757|gb|AAO20901.1| Mdr3 [Takifugu rubripes] 722 0.0
gi|45361353|ref|NP_989254.1| hypothetical protein MGC76216 [Xeno... 722 0.0
gi|9961250|ref|NP_061337.1| ATP-binding cassette, subfamily B, m... 721 0.0
gi|283552|pir||S27338 P-glycoprotein C - Caenorhabditis elegans ... 711 0.0
gi|72475|pir||DVMS1A multidrug resistance protein 1a - mouse (fr... 706 0.0
gi|39595964|emb|CAE67467.1| Hypothetical protein CBG12969 [Caeno... 698 0.0
gi|31213429|ref|XP_315658.1| ENSANGP00000021663 [Anopheles gambi... 697 0.0
gi|39587988|emb|CAE57219.1| Hypothetical protein CBG00079 [Caeno... 695 0.0
gi|40644167|emb|CAC86593.1| sister of P-glycoprotein [Platichthy... 695 0.0
gi|17567265|ref|NP_510126.1| P-GlycoProtein related (pgp-12) [Ca... 695 0.0
gi|14030565|gb|AAK52958.1| bile salt export pump [Raja erinacea] 692 0.0
gi|39587992|emb|CAE57223.1| Hypothetical protein CBG00086 [Caeno... 691 0.0
gi|17567269|ref|NP_510128.1| P-GlycoProtein related (146.8 kD) (... 690 0.0
gi|27656758|gb|AAO20902.1| Mdr2 [Takifugu rubripes] 689 0.0
gi|6472653|dbj|BAA87071.1| multi-drug resistance related mRNA [F... 688 0.0
gi|9961252|ref|NP_061338.1| ATP-binding cassette, subfamily B, m... 688 0.0
gi|17567267|ref|NP_510127.1| P-GlycoProtein related (pgp-13) [Ca... 686 0.0
gi|18496816|gb|AAL74249.1| ABC transporter AbcB2 [Dictyostelium ... 677 0.0
gi|12643301|sp|O95342|AB11_HUMAN Bile salt export pump (ATP-bind... 674 0.0
gi|4704820|gb|AAD28285.1| bile salt export pump [Homo sapiens] 674 0.0
gi|21536378|ref|NP_003733.2| ATP-binding cassette, sub-family B ... 673 0.0
gi|39587990|emb|CAE57221.1| Hypothetical protein CBG00083 [Caeno... 672 0.0
gi|393116|gb|AAA93553.1| P-glycoprotein 5 671 0.0
gi|22535563|dbj|BAC10738.1| putative multidrug resistance protei... 669 0.0
gi|13929072|ref|NP_113948.1| ATP-binding cassette, sub-family B ... 666 0.0
gi|7514034|pir||T42228 P-glycoprotein sister - rat >gnl|BL_ORD_I... 665 0.0
gi|39587987|emb|CAE57218.1| Hypothetical protein CBG00078 [Caeno... 665 0.0
gi|15234322|ref|NP_192091.1| multidrug resistance P-glycoprotein... 662 0.0
gi|13641444|gb|AAK31736.1| p-glycoprotein [Mucor racemosus] 662 0.0
gi|25455873|pir||T52319 P-glycoprotein-like protein pgp3 [import... 661 0.0
gi|11038656|ref|NP_066302.1| ATP-binding cassette, sub-family B,... 660 0.0
gi|18496818|gb|AAL74250.1| ABC transporter AbcB3 [Dictyostelium ... 658 0.0
gi|12585141|sp|Q9N0V3|AB11_RABIT Bile salt export pump (ATP-bind... 657 0.0
gi|15217785|ref|NP_171753.1| multidrug resistance P-glycoprotein... 657 0.0
gi|48094917|ref|XP_394305.1| similar to ENSANGP00000021663 [Apis... 655 0.0
gi|22026798|ref|NP_523740.2| CG8523-PA [Drosophila melanogaster]... 654 0.0
gi|27368859|emb|CAD59587.1| MDR-like ABC transporter [Oryza sati... 654 0.0
gi|15237456|ref|NP_199466.1| ABC transporter family protein [Ara... 652 0.0
gi|266518|sp|Q00449|MDR4_DROME Multidrug resistance protein homo... 650 0.0
gi|24653245|ref|NP_523724.2| CG3879-PA [Drosophila melanogaster]... 649 0.0
gi|50546639|ref|XP_500789.1| hypothetical protein [Yarrowia lipo... 649 0.0
gi|46390962|dbj|BAD16475.1| putative multidrug resistance p-glyc... 649 0.0
gi|15228506|ref|NP_189528.1| multidrug resistance P-glycoprotein... 649 0.0
gi|24324262|gb|AAN28720.2| MDR-like p-glycoprotein [Arabidopsis ... 649 0.0
gi|15217786|ref|NP_171754.1| multidrug resistance P-glycoprotein... 648 0.0
gi|15232978|ref|NP_189480.1| P-glycoprotein, putative [Arabidops... 648 0.0
gi|25407562|pir||H85202 hypothetical protein AT4g18050 [imported... 648 0.0
gi|4204793|gb|AAD10836.1| P-glycoprotein [Solanum tuberosum] 647 0.0
gi|15234323|ref|NP_192092.1| multidrug resistance P-glycoprotein... 647 0.0
gi|422285|pir||S30327 multidrug resistance protein 1 - Entamoeba... 646 0.0
gi|26449438|dbj|BAC41846.1| putative P-glycoprotein [Arabidopsis... 646 0.0
gi|15147363|gb|AAG01549.3| multidrug resistance protein MDR [Tri... 645 0.0
gi|15229473|ref|NP_189475.1| ABC transporter family protein [Ara... 645 0.0
gi|15226477|ref|NP_182223.1| multidrug resistant (MDR) ABC trans... 645 0.0
gi|27368849|emb|CAD59582.1| MDR-like ABC transporter [Oryza sati... 644 0.0
gi|157873|gb|AAA16186.1| P-glycoprotein/multidrug resistance pro... 644 0.0
gi|1079107|pir||A47377 multidrug resistance protein Mdr50 - frui... 644 0.0
gi|15228695|ref|NP_191774.1| multidrug resistant (MDR) ABC trans... 643 0.0
gi|22328760|ref|NP_193539.2| ABC transporter family protein [Ara... 643 0.0
gi|19032275|dbj|BAB85651.1| multidrug resistance protein 1 homol... 642 0.0
gi|50750485|ref|XP_422016.1| PREDICTED: similar to liver bile sa... 642 0.0
gi|9294577|dbj|BAB02858.1| multidrug resistance p-glycoprotein; ... 641 0.0
gi|422286|pir||S30328 multidrug resistance protein 2 - Entamoeba... 641 0.0
gi|25297456|pir||F86155 probable ABC transporter [imported] - Ar... 640 0.0
gi|34913530|ref|NP_918112.1| putative multidrug resistance prote... 640 0.0
gi|22331385|ref|NP_683599.1| P-glycoprotein, putative [Arabidops... 639 0.0
gi|2673951|gb|AAB88657.1| multidrug resistance protein 1 [Asperg... 638 0.0
gi|18033873|gb|AAL57243.1| ATP-binding cassette transporter ABC4... 637 0.0
gi|27368865|emb|CAD59590.1| MDR-like ABC transporter [Oryza sati... 635 e-180
gi|34894326|ref|NP_908488.1| unnamed protein product [Oryza sati... 634 e-180
gi|27368847|emb|CAD59581.1| MDR-like ABC transporter [Oryza sati... 634 e-180
gi|49080124|ref|XP_403624.1| hypothetical protein UM06009.1 [Ust... 634 e-180
gi|15232977|ref|NP_189479.1| P-glycoprotein, putative [Arabidops... 633 e-180
gi|5456701|gb|AAD43626.1| multidrug resistance protein MDR [Emer... 632 e-179
gi|49089458|ref|XP_406437.1| hypothetical protein AN2300.2 [Aspe... 631 e-179
gi|50556486|ref|XP_505651.1| hypothetical protein [Yarrowia lipo... 630 e-179
gi|15217776|ref|NP_174115.1| multidrug resistance P-glycoprotein... 629 e-178
gi|4574224|gb|AAD23956.1| multidrug resistance transporter homol... 629 e-178
gi|15228052|ref|NP_181228.1| multidrug resistance P-glycoprotein... 628 e-178
gi|34913544|ref|NP_918119.1| putative multidrug resistance prote... 626 e-177
gi|21464386|gb|AAM51996.1| RE14657p [Drosophila melanogaster] 626 e-177
gi|21740907|emb|CAD40903.1| OSJNBa0036B21.21 [Oryza sativa (japo... 626 e-177
gi|17136662|ref|NP_476831.1| CG10181-PA [Drosophila melanogaster... 625 e-177
gi|103252|pir||B41249 multidrug resistance protein homolog Mdr65... 625 e-177
gi|46390486|dbj|BAD15946.1| putative MDR-like ABC transporter [O... 625 e-177
gi|27368855|emb|CAD59585.1| MDR-like ABC transporter [Oryza sati... 625 e-177
gi|7442649|pir||T06165 multidrug resistance protein 1 homolog - ... 625 e-177
gi|14715462|dbj|BAB62040.1| CjMDR1 [Coptis japonica] 623 e-177
gi|22655312|gb|AAM98246.1| putative ABC transporter [Arabidopsis... 622 e-176
gi|27368839|emb|CAD59577.1| MDR-like ABC transporter [Oryza sati... 621 e-176
gi|9294571|dbj|BAB02852.1| multidrug resistance p-glycoprotein; ... 620 e-175
gi|15232975|ref|NP_189477.1| ABC transporter family protein [Ara... 619 e-175
gi|34911450|ref|NP_917072.1| putative multidrug resistance prote... 618 e-175
gi|15217809|ref|NP_174122.1| multidrug resistance P-glycoprotein... 615 e-174
gi|6671365|gb|AAF23176.1| P-glycoprotein [Gossypium hirsutum] 614 e-174
gi|50732439|ref|XP_418636.1| PREDICTED: similar to Multidrug res... 614 e-174
gi|34910738|ref|NP_916716.1| putative P-glycoprotein [Oryza sati... 612 e-173
gi|50260330|gb|EAL22989.1| hypothetical protein CNBA7570 [Crypto... 612 e-173
gi|27368851|emb|CAD59583.1| MDR-like ABC transporter [Oryza sati... 611 e-173
gi|5733124|gb|AAD49436.1| P-glycoprotein [Onchocerca volvulus] 611 e-173
gi|33307712|gb|AAQ03033.1| P-glycoprotein [Homo sapiens] 610 e-173
gi|11346278|pir||T43261 multidrug resistance protein 1 - fungus ... 608 e-172
gi|20466380|gb|AAM20507.1| P-glycoprotein-2 [Arabidopsis thaliana] 608 e-172
gi|15236067|ref|NP_194326.1| multidrug resistance P-glycoprotein... 608 e-172
gi|38049160|gb|AAR10387.1| P-glycoprotein 1 [Sorghum bicolor] 605 e-171
gi|19075765|ref|NP_588265.1| leptomycin b resistance protein, ab... 604 e-171
gi|50543630|ref|XP_499981.1| hypothetical protein [Yarrowia lipo... 604 e-171
gi|7442651|pir||T14805 hypothetical protein F15J5.20 - Arabidops... 603 e-171
gi|45735908|dbj|BAD12940.1| putative P-glycoprotein 1 [Oryza sat... 603 e-171
gi|15220188|ref|NP_172538.1| P-glycoprotein, putative [Arabidops... 603 e-171
gi|218550|dbj|BAA01537.1| pmd1 protein [Schizosaccharomyces pombe] 602 e-170
gi|27368861|emb|CAD59588.1| MDR-like ABC transporter [Oryza sati... 599 e-169
gi|24659289|ref|NP_648040.1| CG10226-PA [Drosophila melanogaster... 599 e-169
gi|38345252|emb|CAD41096.2| OSJNBb0011N17.13 [Oryza sativa (japo... 599 e-169
gi|27368867|emb|CAD59591.1| MDR-like ABC transporter [Oryza sati... 595 e-168
gi|36413607|ref|NP_848654.2| ATP-binding cassette, sub-family B,... 593 e-167
gi|27368845|emb|CAD59580.1| MDR-like ABC transporter [Oryza sati... 588 e-166
gi|7493911|pir||T30882 multidrug resistance protein 1 - Aspergil... 587 e-166
gi|9294508|dbj|BAB02613.1| P-glycoprotein; multi-drug resistance... 587 e-166
gi|7494131|pir||T30804 P-glycoprotein 6 - Entamoeba histolytica ... 587 e-166
gi|27368869|emb|CAD59592.1| MDR-like ABC transporter [Oryza sati... 576 e-162
gi|46129276|ref|XP_388999.1| hypothetical protein FG08823.1 [Gib... 575 e-162
gi|7494503|pir||T30855 multidrug resistance protein 2 - fluke (S... 571 e-161
gi|38098857|gb|AAR11078.1| ATP binding cassette transporter [Lep... 567 e-160
gi|37695542|gb|AAR00316.1| PGP1; ZMPGP1 [Zea mays] 561 e-158
gi|27368843|emb|CAD59579.1| MDR-like ABC transporter [Oryza sati... 560 e-158
gi|25297460|pir||B86240 protein F20B24.12 [imported] - Arabidops... 558 e-157
gi|37806003|dbj|BAC99416.1| putative MDR-like ABC transporter [O... 555 e-156
gi|16304396|gb|AAL15148.1| multidrug resistance transporter-like... 552 e-155
gi|49089656|ref|XP_406486.1| hypothetical protein AN2349.2 [Aspe... 548 e-154
gi|5456699|gb|AAD43625.1| ATP-binding cassette multidrug transpo... 543 e-152
gi|49092568|ref|XP_407745.1| hypothetical protein AN3608.2 [Aspe... 537 e-151
gi|33299999|emb|CAA88940.3| Hypothetical protein DH11.3 [Caenorh... 529 e-148
gi|27368841|emb|CAD59578.1| MDR-like ABC transporter [Oryza sati... 526 e-147
gi|46109604|ref|XP_381860.1| hypothetical protein FG01684.1 [Gib... 526 e-147
gi|46111809|ref|XP_382962.1| hypothetical protein FG02786.1 [Gib... 526 e-147
gi|17532731|ref|NP_495674.1| P-GlycoProtein related (pgp-11) [Ca... 525 e-147
gi|49084736|ref|XP_404541.1| hypothetical protein AN0404.2 [Aspe... 522 e-146
gi|49081308|ref|XP_404076.1| hypothetical protein UM06461.1 [Ust... 518 e-145
gi|39587763|emb|CAE67781.1| Hypothetical protein CBG13356 [Caeno... 517 e-145
gi|7498268|pir||T20386 hypothetical protein DH11.3 - Caenorhabdi... 515 e-144
gi|17551158|ref|NP_509205.1| P-GlycoProtein related (pgp-10) [Ca... 511 e-143
gi|32418014|ref|XP_329485.1| hypothetical protein [Neurospora cr... 511 e-143
gi|39586807|emb|CAE65850.1| Hypothetical protein CBG10984 [Caeno... 506 e-141
gi|32400322|dbj|BAC78652.1| ABC transporter [Aspergillus oryzae] 504 e-141
gi|46116988|ref|XP_384512.1| hypothetical protein FG04336.1 [Gib... 502 e-140
gi|49097828|ref|XP_410374.1| hypothetical protein AN6237.2 [Aspe... 502 e-140
gi|2360941|gb|AAB69130.1| P-glycoprotein 495 e-138
gi|46125007|ref|XP_387057.1| hypothetical protein FG06881.1 [Gib... 494 e-138
gi|46114962|ref|XP_383499.1| hypothetical protein FG03323.1 [Gib... 492 e-137
gi|159363|gb|AAA02977.1| P-glycoprotein 488 e-136
gi|730011|sp|Q06034|MDR1_LEIEN Multidrug resistance protein 1 (P... 488 e-136
gi|7522025|pir||T30191 multidrug resistance protein 1 - Aureobas... 488 e-136
gi|38099353|gb|EAA46710.1| hypothetical protein MG09931.4 [Magna... 487 e-136
gi|4521245|dbj|BAA76299.1| LAMDR1 [Leishmania mexicana amazonensis] 486 e-135
gi|32402932|ref|XP_322079.1| hypothetical protein [Neurospora cr... 486 e-135
gi|42820674|emb|CAF31987.1| ABC transporter, putative [Aspergill... 481 e-134
gi|20530737|gb|AAM27211.1| multidrug resistance protein 4 [Asper... 481 e-134
gi|49138261|ref|XP_413479.1| hypothetical protein AN9342.2 [Aspe... 478 e-133
gi|46107316|ref|XP_380717.1| hypothetical protein FG00541.1 [Gib... 476 e-132
gi|18033871|gb|AAL57242.1| ATP-binding cassette transporter ABC3... 476 e-132
gi|7442650|pir||JG0166 LaMDR1 protein - Leishmania mexicana amaz... 471 e-131
gi|38101651|gb|EAA48581.1| hypothetical protein MG00239.4 [Magna... 469 e-130
gi|24960750|gb|AAN65444.1| Hypothetical protein [Oryza sativa (j... 463 e-128
gi|13346110|gb|AAK19598.1| putative ABC transporter [Sterkiella ... 452 e-125
gi|4587971|gb|AAD25925.1| ABC transporter protein AtrC [Emericel... 448 e-124
gi|38108326|gb|EAA54363.1| hypothetical protein MG02348.4 [Magna... 444 e-123
gi|38099261|gb|EAA46627.1| hypothetical protein MG08970.4 [Magna... 438 e-121
gi|25990364|gb|AAN76500.1| P-glycoprotein [Homo sapiens] 435 e-120
gi|46401536|dbj|BAD16632.1| LAMDR2 [Leishmania amazonensis] 429 e-118
gi|4768949|gb|AAD29692.1| sister of P-glycoprotein [Fundulus het... 424 e-117
gi|17567271|ref|NP_510129.1| P-GlycoProtein related (pgp-15) [Ca... 416 e-114
gi|34935680|ref|XP_234725.2| similar to P-glycoprotein [Rattus n... 414 e-114
gi|47225422|emb|CAG11905.1| unnamed protein product [Tetraodon n... 408 e-112
gi|47212418|emb|CAG12367.1| unnamed protein product [Tetraodon n... 399 e-109
gi|45775220|gb|AAK83023.2| truncated P-glycoprotein [Rattus norv... 398 e-109
gi|18253111|dbj|BAB83959.1| multidrug resistance p-glycoprotein ... 394 e-107
gi|191159|gb|AAA37006.1| P-glycoprotein (pgp1) 387 e-105
gi|72478|pir||DVHY2C multidrug resistance protein 2 - Chinese ha... 383 e-104
gi|45735909|dbj|BAD12941.1| putative P-glycoprotein 1 [Oryza sat... 382 e-104
gi|45735907|dbj|BAD12939.1| putative P-glycoprotein 1 [Oryza sat... 380 e-103
gi|47225423|emb|CAG11906.1| unnamed protein product [Tetraodon n... 377 e-103
gi|50304431|ref|XP_452165.1| unnamed protein product [Kluyveromy... 372 e-101
gi|191153|gb|AAA37003.1| p-glycoprotein 370 e-100
gi|47218631|emb|CAG04960.1| unnamed protein product [Tetraodon n... 353 2e-95
gi|50291615|ref|XP_448240.1| unnamed protein product [Candida gl... 331 9e-89
gi|19698967|gb|AAL91219.1| P-glycoprotein, putative [Arabidopsis... 321 7e-86
gi|41052996|dbj|BAD07905.1| putative MDR-like ABC transporter [O... 319 3e-85
gi|50425037|ref|XP_461110.1| unnamed protein product [Debaryomyc... 313 3e-83
gi|47900485|gb|AAT39242.1| putative P-glycoprotein [Oryza sativa... 312 3e-83
gi|27753995|ref|NP_083296.2| RIKEN cDNA 4833412N02 [Mus musculus... 305 7e-81
gi|26339816|dbj|BAC33571.1| unnamed protein product [Mus musculus] 305 7e-81
gi|18875456|gb|AAL74251.2| ABC transporter AbcB4 [Dictyostelium ... 304 9e-81
gi|1174535|gb|AAA86666.1| ATP-binding cassette protein [Fasciola... 303 2e-80
gi|34525|emb|CAA29547.1| P-glycoprotein (431 AA) [Homo sapiens] 303 3e-80
gi|26345292|dbj|BAC36297.1| unnamed protein product [Mus musculus] 302 3e-80
gi|50552398|ref|XP_503609.1| hypothetical protein [Yarrowia lipo... 302 3e-80
gi|12278525|gb|AAG49002.1| putative ABC transporter [Hordeum vul... 300 1e-79
gi|12061244|gb|AAG45492.1| 36I5.4 [Oryza sativa (japonica cultiv... 299 4e-79
gi|34853987|ref|XP_342615.1| similar to RIKEN cDNA 4833412N02 [R... 299 4e-79
gi|20453064|gb|AAM19777.1| At2g39480/F12L6.14 [Arabidopsis thali... 298 5e-79
gi|15225474|ref|NP_181480.1| ABC transporter family protein [Ara... 298 5e-79
gi|21326114|gb|AAM47580.1| putative ABC-transporter-like protein... 297 1e-78
gi|18496654|gb|AAL74186.1| putative ABC transporter [Triticum mo... 297 1e-78
gi|18496655|gb|AAL74187.1| putative ABC transporter [Triticum mo... 296 2e-78
gi|13123950|sp|Q9NUT2|ABC8_HUMAN ATP-binding cassette, sub-famil... 296 3e-78
gi|6005804|ref|NP_009119.1| ATP-binding cassette, sub-family B, ... 296 3e-78
gi|12278526|gb|AAG49003.1| putative ABC transporter [Hordeum vul... 295 4e-78
gi|7023646|dbj|BAA92038.1| unnamed protein product [Homo sapiens] 295 7e-78
gi|10177549|dbj|BAB10828.1| ABC transporter-like protein [Arabid... 295 7e-78
gi|22327455|ref|NP_198720.2| ABC transporter (TAP2) [Arabidopsis... 295 7e-78
gi|19335724|gb|AAL85486.1| transporter associated with antigen p... 294 1e-77
gi|21753735|dbj|BAC04392.1| unnamed protein product [Homo sapiens] 293 2e-77
gi|18496814|gb|AAL74248.1| ABC transporter AbcB1 [Dictyostelium ... 293 2e-77
gi|10241621|emb|CAC09461.1| putative P-glycoprotein [Oryza sativ... 292 4e-77
gi|18124158|gb|AAL59848.1| ATP-binding cassette protein 3 [Crypt... 291 8e-77
gi|32399046|emb|CAD98286.1| ATP-binding cassette transporter [Cr... 291 8e-77
gi|32966961|gb|AAP92331.1| multixenobiotic resistance protein [C... 289 3e-76
gi|15233244|ref|NP_191092.1| ABC transporter family protein [Ara... 289 4e-76
gi|27368853|emb|CAD59584.1| MDR-like ABC transporter [Oryza sati... 286 3e-75
gi|17565938|ref|NP_506645.1| HAlF transporter, PGP related (haf-... 285 4e-75
gi|7510080|pir||T31617 hypothetical protein Y50E8A.m - Caenorhab... 285 4e-75
gi|24641565|ref|NP_572810.1| CG1824-PA [Drosophila melanogaster]... 284 1e-74
gi|17543740|ref|NP_502776.1| HAlF transporter, PGP related (haf-... 284 1e-74
gi|34851887|ref|XP_341718.1| similar to ABC transporter [Rattus ... 283 2e-74
gi|30519701|emb|CAD90041.1| putative ATP-binding cassette transp... 279 3e-73
gi|9506367|ref|NP_062425.1| ATP-binding cassette, sub-family B, ... 279 4e-73
gi|39581765|emb|CAE74138.1| Hypothetical protein CBG21809 [Caeno... 277 1e-72
gi|34906082|ref|NP_914388.1| putative P-glycoprotein [Oryza sati... 276 3e-72
gi|40787796|gb|AAH64930.1| ATP-binding cassette, sub-family B, m... 276 3e-72
gi|9961244|ref|NP_036221.1| ATP-binding cassette, sub-family B, ... 275 8e-72
gi|5911322|gb|AAD55751.1| transporter associated with antigen pr... 274 1e-71
gi|39583384|emb|CAE66359.1| Hypothetical protein CBG11616 [Caeno... 273 2e-71
gi|39582351|emb|CAE67600.1| Hypothetical protein CBG13145 [Caeno... 273 2e-71
gi|9992887|gb|AAG11416.1| TagA [Dictyostelium discoideum] 272 4e-71
gi|17533971|ref|NP_495537.1| HAlF transporter, PGP related (haf-... 272 5e-71
gi|31216972|ref|XP_316337.1| ENSANGP00000013796 [Anopheles gambi... 271 1e-70
gi|26006275|dbj|BAC41480.1| mKIAA1520 protein [Mus musculus] 270 1e-70
gi|22095457|sp|Q9JJ59|ABC9_MOUSE ATP-binding cassette, sub-famil... 270 1e-70
gi|11560034|ref|NP_071574.1| TAP-like ABC transporter [Rattus no... 270 2e-70
gi|9845230|ref|NP_063928.1| ATP-binding cassette, sub-family B, ... 270 2e-70
gi|12248755|dbj|BAB20265.1| mono ATP-binding cassette protein [H... 269 4e-70
gi|21673056|ref|NP_661121.1| ABC transporter, ATP-binding protei... 268 5e-70
gi|16330165|ref|NP_440893.1| ABC transporter [Synechocystis sp. ... 268 7e-70
gi|1016270|gb|AAA79094.1| p-glycoprotein 268 7e-70
gi|48864170|ref|ZP_00318063.1| COG1132: ABC-type multidrug trans... 268 9e-70
gi|9955966|ref|NP_062571.1| ATP-binding cassette, sub-family B (... 268 9e-70
gi|22959359|ref|ZP_00007012.1| COG1132: ABC-type multidrug trans... 267 2e-69
gi|31206493|ref|XP_312209.1| ENSANGP00000002692 [Anopheles gambi... 266 2e-69
gi|5823084|gb|AAD53033.1| TAP1 protein [Oncorhynchus mykiss] 266 2e-69
gi|1743404|emb|CAB05917.1| transport-associated protein [Salmo s... 266 2e-69
gi|21622336|emb|CAD36977.1| probable multidrug resistance protei... 266 2e-69
gi|22974777|ref|ZP_00020923.1| hypothetical protein [Chloroflexu... 266 4e-69
gi|9955968|ref|NP_062570.1| ATP-binding cassette, sub-family B (... 266 4e-69
gi|23016084|ref|ZP_00055844.1| COG1132: ABC-type multidrug trans... 265 6e-69
gi|5733401|gb|AAD49563.1| P-glycoprotein-like protein [Onchocerc... 265 6e-69
gi|48870952|ref|ZP_00323669.1| COG1132: ABC-type multidrug trans... 264 1e-68
gi|49474685|ref|YP_032727.1| ABC transporter, ATP-binding protei... 263 2e-68
gi|49476161|ref|YP_034202.1| ABC transporter, ATP-binding protei... 263 2e-68
gi|47077792|dbj|BAD18770.1| unnamed protein product [Homo sapiens] 263 3e-68
gi|48895152|ref|ZP_00328136.1| COG1132: ABC-type multidrug trans... 262 4e-68
gi|39992420|gb|AAH64384.1| ABCB9 protein [Homo sapiens] 262 4e-68
gi|48855938|ref|ZP_00310096.1| COG1132: ABC-type multidrug trans... 262 4e-68
gi|27452581|gb|AAN71739.1| ABCB9-like TAP-family protein [Petrom... 262 4e-68
gi|28211454|ref|NP_782398.1| multidrug resistance ABC transporte... 262 5e-68
gi|47575345|ref|ZP_00245380.1| COG1132: ABC-type multidrug trans... 260 1e-67
gi|33861655|ref|NP_893216.1| ABC transporter, multidrug efflux f... 259 3e-67
gi|21397643|ref|NP_653628.1| ABC_tran, ABC transporter [Bacillus... 259 4e-67
gi|17229638|ref|NP_486186.1| ATP-binding protein of ABC transpor... 259 4e-67
gi|23397593|ref|NP_569844.2| CG3156-PA [Drosophila melanogaster]... 258 6e-67
gi|46119497|ref|ZP_00176704.2| COG1132: ABC-type multidrug trans... 258 6e-67
gi|49478904|ref|YP_039169.1| multidrug resistance ABC transporte... 258 7e-67
gi|8176565|dbj|BAA96370.1| ABC protein [Physarum polycephalum] 258 7e-67
gi|49077780|ref|XP_402711.1| hypothetical protein UM05096.1 [Ust... 258 7e-67
gi|15616453|ref|NP_244759.1| ABC transporter (ATP-binding protei... 258 1e-66
gi|47567391|ref|ZP_00238104.1| ABC transporter, ATP-binding/perm... 257 2e-66
gi|23104911|ref|ZP_00091371.1| COG1132: ABC-type multidrug trans... 256 2e-66
gi|17988594|ref|NP_541227.1| ABC TRANSPORTER ATP-BINDING PROTEIN... 256 3e-66
gi|30023215|ref|NP_834846.1| Multidrug resistance ABC transporte... 256 3e-66
gi|48730042|ref|ZP_00263791.1| COG1132: ABC-type multidrug trans... 256 3e-66
gi|23125993|ref|ZP_00107905.1| COG2274: ABC-type bacteriocin/lan... 256 3e-66
gi|23500772|ref|NP_700212.1| ABC transporter, ATP-binding/permea... 256 4e-66
gi|17228136|ref|NP_484684.1| ATP-binding protein of ABC transpor... 256 4e-66
gi|2147880|pir||I48120 P-glycoprotein - Chinese hamster (fragmen... 256 4e-66
gi|42784331|ref|NP_981578.1| ABC transporter, ATP-binding/permea... 255 5e-66
gi|46113651|ref|ZP_00183228.2| COG1132: ABC-type multidrug trans... 255 5e-66
gi|15613504|ref|NP_241807.1| ABC transporter (ATP-binding protei... 255 5e-66
gi|25143468|ref|NP_490828.2| HAlF transporter, PGP related (62.5... 254 8e-66
gi|27467336|ref|NP_763973.1| ATP-binding cassette transporter A ... 254 1e-65
gi|15923633|ref|NP_371167.1| ATP-binding cassette transporter A ... 254 1e-65
gi|42519083|ref|NP_965013.1| ABC transporter ATPase and permease... 254 1e-65
gi|5911326|gb|AAD55753.1| transporter associated with antigen pr... 254 1e-65
gi|16127504|ref|NP_422068.1| ABC transporter, HlyB/MsbA family [... 254 1e-65
gi|7511165|pir||T32865 hypothetical protein ZK484.2 - Caenorhabd... 253 2e-65
gi|1708329|sp|P53706|HST6_CANAL ATP-dependent permease HST6 (STE... 253 2e-65
gi|17511077|ref|NP_491754.1| HAlF transporter, PGP related (90.8... 253 2e-65
gi|2119779|pir||S50217 multidrug resistance protein 3 - rat (fra... 253 2e-65
gi|5823088|gb|AAD53035.1| TAP2B protein [Oncorhynchus mykiss] 253 2e-65
gi|46913988|emb|CAG20770.1| putative transport ATP-binding prote... 253 2e-65
gi|23469088|ref|ZP_00124423.1| COG1132: ABC-type multidrug trans... 253 3e-65
gi|16080535|ref|NP_391362.1| yvcC [Bacillus subtilis subsp. subt... 253 3e-65
gi|39582604|emb|CAE63923.1| Hypothetical protein CBG08495 [Caeno... 253 3e-65
gi|50510160|dbj|BAD31127.1| putative ATP-binding cassette, sub-f... 253 3e-65
gi|46437756|gb|EAK97097.1| hypothetical protein CaO19.7440 [Cand... 252 4e-65
gi|21282334|ref|NP_645422.1| ATP-binding cassette transporter A ... 252 5e-65
gi|23127335|ref|ZP_00109208.1| COG1132: ABC-type multidrug trans... 252 5e-65
gi|48732123|ref|ZP_00265866.1| COG1132: ABC-type multidrug trans... 252 5e-65
gi|30686893|ref|NP_194275.2| ABC transporter family protein [Ara... 252 5e-65
gi|1262136|emb|CAA62898.1| ATP-binding cassette transporter A [S... 251 9e-65
gi|18124194|gb|AAL59859.1| transporter associated with antigen p... 251 1e-64
gi|33302629|sp|Q9CHL8|LMRA_LACLA Multidrug resistance ABC transp... 251 1e-64
gi|15672693|ref|NP_266867.1| multidrug resistance ABC transporte... 251 1e-64
gi|15924856|ref|NP_372390.1| ABC transporter homolog [Staphyloco... 250 2e-64
gi|3915458|sp|O14286|YD01_SCHPO Putative ABC transporter C15A10.... 249 3e-64
gi|37676347|ref|NP_936743.1| ABC-type multidrug transport system... 249 3e-64
gi|42781108|ref|NP_978355.1| ABC transporter, ATP-binding/permea... 249 3e-64
gi|23098860|ref|NP_692326.1| ABC transporter ATP-binding protein... 249 3e-64
gi|47217174|emb|CAG11010.1| unnamed protein product [Tetraodon n... 249 5e-64
gi|2147879|pir||I48119 P-glycoprotein - Chinese hamster (fragmen... 249 5e-64
gi|1743406|emb|CAB05918.1| transport-associated protein [Salmo s... 249 5e-64
gi|30248729|ref|NP_840799.1| ABC transporter, fused permease and... 249 5e-64
gi|7445902|pir||T13416 hypothetical protein 171D11.2 - fruit fly... 249 5e-64
gi|15966528|ref|NP_386881.1| PROBABLE ABC TRANSPORTER ATP-BINDIN... 249 5e-64
gi|48771097|ref|ZP_00275440.1| COG1132: ABC-type multidrug trans... 249 5e-64
gi|34496280|ref|NP_900495.1| transport ATP-binding protein msbA ... 249 5e-64
gi|48892154|ref|ZP_00325566.1| COG1132: ABC-type multidrug trans... 248 6e-64
gi|29654183|ref|NP_819875.1| ABC transporter, ATP-binding/permea... 248 6e-64
gi|16077935|ref|NP_388749.1| ygaD [Bacillus subtilis subsp. subt... 248 6e-64
gi|49477449|ref|YP_036121.1| multidrug resistance ABC transporte... 248 6e-64
gi|39997358|ref|NP_953309.1| ABC transporter, ATP-binding protei... 248 6e-64
gi|15641880|ref|NP_231512.1| transport ATP-binding protein MsbA ... 248 6e-64
gi|9187883|emb|CAB97048.1| mitochondrial half-ABC transporter [A... 248 8e-64
gi|50741416|ref|XP_419578.1| PREDICTED: similar to ATP-binding c... 248 8e-64
gi|27366635|ref|NP_762162.1| ABC-type multidrug transport system... 248 1e-63
gi|15237155|ref|NP_200635.1| mitochondrial half-ABC transporter ... 248 1e-63
gi|15600190|ref|NP_253684.1| transport protein MsbA [Pseudomonas... 247 1e-63
gi|20807317|ref|NP_622488.1| ABC-type multidrug/protein/lipid tr... 247 1e-63
gi|23127481|ref|ZP_00109350.1| COG1132: ABC-type multidrug trans... 247 1e-63
gi|47225421|emb|CAG11904.1| unnamed protein product [Tetraodon n... 247 2e-63
gi|45516864|ref|ZP_00168416.1| COG1132: ABC-type multidrug trans... 247 2e-63
gi|33302625|sp|P97046|LMRA_LACLC Multidrug resistance ABC transp... 247 2e-63
gi|23098355|ref|NP_691821.1| ABC transporter ATP-binding protein... 247 2e-63
gi|37525574|ref|NP_928918.1| Probable transport ATP-binding prot... 246 2e-63
gi|21242281|ref|NP_641863.1| ABC transporter ATP-binding protein... 246 2e-63
gi|50085455|ref|YP_046965.1| lipid transport protein, flippase (... 246 2e-63
gi|22298120|ref|NP_681367.1| ABC transporter ATP-binding protein... 246 2e-63
gi|2126572|pir||JC4554 ABC-type transporter homolog - Staphyloco... 246 3e-63
gi|49096410|ref|XP_409665.1| hypothetical protein AN5528.2 [Aspe... 246 3e-63
gi|31217619|ref|XP_316463.1| ENSANGP00000004277 [Anopheles gambi... 246 3e-63
gi|45521342|ref|ZP_00172862.1| COG1132: ABC-type multidrug trans... 246 3e-63
gi|15963913|ref|NP_384266.1| PUTATIVE ATP-BINDING ABC TRANSPORTE... 246 3e-63
gi|46396288|sp|Q47908|MSBA_FRANO Lipid A export ATP-binding/perm... 246 4e-63
gi|37955144|gb|AAO64432.1| MDR-like ATPase [Oenococcus oeni] 246 4e-63
gi|290801|gb|AAD15237.1| member of super-family of ABC proteins 246 4e-63
gi|22760375|dbj|BAC11171.1| unnamed protein product [Homo sapiens] 246 4e-63
gi|37781028|gb|AAP36720.1| transporter associated with antigen p... 246 4e-63
gi|45916934|ref|ZP_00195995.2| COG1132: ABC-type multidrug trans... 246 4e-63
gi|39579610|emb|CAE56497.1| Hypothetical protein CBG24214 [Caeno... 245 5e-63
gi|15925418|ref|NP_372952.1| hypothetical protein SAV2428 [Staph... 245 5e-63
gi|28900647|ref|NP_800302.1| putative ATP-binding/permease fusio... 245 7e-63
gi|46133688|ref|ZP_00157567.2| COG1132: ABC-type multidrug trans... 245 7e-63
gi|21284080|ref|NP_647168.1| ORFID:MW2351~hypothetical protein, ... 245 7e-63
gi|17228079|ref|NP_484627.1| ATP-binding protein of ABC transpor... 244 8e-63
gi|26246941|ref|NP_752981.1| Probable transport ATP-binding prot... 244 8e-63
gi|15800775|ref|NP_286789.1| ATP-binding transport protein; mult... 244 8e-63
gi|30248923|ref|NP_840993.1| ABC transporter, fused permease and... 244 1e-62
gi|49475315|ref|YP_033356.1| ABC transporter, ATP-binding protei... 244 1e-62
gi|28199828|ref|NP_780142.1| ABC transporter ATP-binding protein... 244 1e-62
gi|425474|gb|AAA66476.1| SMDR1 244 1e-62
gi|48864787|ref|ZP_00318661.1| COG1132: ABC-type multidrug trans... 244 1e-62
gi|23502573|ref|NP_698700.1| ABC transporter, ATP binding/permea... 244 1e-62
gi|49474077|ref|YP_032119.1| ABC transporter, ATP-binding protei... 244 1e-62
gi|47569984|ref|ZP_00240647.1| multidrug resistance ABC transpor... 243 2e-62
gi|42779663|ref|NP_976910.1| ABC transporter, ATP-binding/permea... 243 2e-62
gi|49484644|ref|YP_041868.1| ABC transporter ATP-binding protein... 243 2e-62
gi|16329858|ref|NP_440586.1| ABC transporter [Synechocystis sp. ... 243 2e-62
gi|49481736|ref|YP_034789.1| ABC transporter ATP-binding and per... 243 2e-62
gi|21230937|ref|NP_636854.1| ABC transporter ATP-binding protein... 243 2e-62
gi|48895639|ref|ZP_00328623.1| COG2274: ABC-type bacteriocin/lan... 243 3e-62
gi|15643057|ref|NP_228100.1| ABC transporter, ATP-binding protei... 243 3e-62
gi|37680540|ref|NP_935149.1| transport ATP-binding protein MsbA ... 243 3e-62
gi|30020094|ref|NP_831725.1| Multidrug resistance ABC transporte... 242 4e-62
gi|16801948|ref|NP_472216.1| similar to ABC transporter (ATP-bin... 242 4e-62
gi|48858770|ref|ZP_00312716.1| COG1132: ABC-type multidrug trans... 242 4e-62
gi|37521765|ref|NP_925142.1| HlyB/MsbA family ABC transporter [G... 242 4e-62
gi|27365418|ref|NP_760946.1| Transport ATP-binding protein MsbA ... 242 4e-62
gi|23100898|ref|NP_694365.1| ABC transporter ATP-binding protein... 242 4e-62
gi|17986606|ref|NP_539240.1| PROBABLE TRANSPORT ATP-BINDING PROT... 242 4e-62
gi|27376619|ref|NP_768148.1| HlyB/MsbA family ABC transporter [B... 242 4e-62
gi|27468468|ref|NP_765105.1| ABC transporter (ATP-binding protei... 242 6e-62
gi|22997178|ref|ZP_00041414.1| COG1132: ABC-type multidrug trans... 242 6e-62
gi|48850584|ref|ZP_00304826.1| COG1132: ABC-type multidrug trans... 242 6e-62
gi|45506572|ref|ZP_00158925.1| COG1132: ABC-type multidrug trans... 241 7e-62
gi|49072024|ref|XP_400301.1| hypothetical protein UM02686.1 [Ust... 241 7e-62
gi|18478983|dbj|BAB84549.1| ABCB3 [Oryzias latipes] 241 7e-62
gi|47572829|ref|ZP_00242870.1| COG1132: ABC-type multidrug trans... 241 7e-62
gi|16272034|ref|NP_438233.1| ABC transporter ATP-binding protein... 241 7e-62
gi|38105373|gb|EAA51811.1| hypothetical protein MG03406.4 [Magna... 241 7e-62
gi|30260686|ref|NP_843063.1| ABC transporter, ATP-binding/permea... 241 9e-62
gi|23102360|ref|ZP_00088871.1| COG5265: ABC-type transport syste... 241 9e-62
gi|23129118|ref|ZP_00110951.1| COG1132: ABC-type multidrug trans... 241 9e-62
gi|21398472|ref|NP_654457.1| ABC_membrane, ABC transporter trans... 241 1e-61
gi|46115926|ref|XP_383981.1| hypothetical protein FG03805.1 [Gib... 241 1e-61
gi|17509565|ref|NP_490739.1| HAlF transporter, PGP related (haf-... 241 1e-61
gi|42520276|ref|NP_966191.1| ABC transporter, HlyB/MsbA family, ... 241 1e-61
gi|16080776|ref|NP_391604.1| ywjA [Bacillus subtilis subsp. subt... 240 2e-61
gi|16804782|ref|NP_466267.1| similar to ABC transporter (ATP-bin... 240 2e-61
gi|22995060|ref|ZP_00039543.1| COG1132: ABC-type multidrug trans... 240 2e-61
gi|13473363|ref|NP_104930.1| ABC transporter, ATP-binding protei... 240 2e-61
gi|41723459|ref|ZP_00150386.1| COG1132: ABC-type multidrug trans... 240 2e-61
gi|46130296|ref|ZP_00165119.2| COG1132: ABC-type multidrug trans... 240 2e-61
gi|49094386|ref|XP_408654.1| hypothetical protein AN4517.2 [Aspe... 240 2e-61
gi|2274803|dbj|BAA21552.1| MDR(Multidrug Resistance)-like gene;H... 240 2e-61
gi|48765071|ref|ZP_00269622.1| COG5265: ABC-type transport syste... 240 2e-61
gi|24585557|ref|NP_610079.2| CG9270-PA [Drosophila melanogaster]... 239 3e-61
gi|33589528|gb|AAQ22531.1| LD15381p [Drosophila melanogaster] 239 3e-61
gi|45512238|ref|ZP_00163805.1| COG1132: ABC-type multidrug trans... 239 3e-61
gi|42527766|ref|NP_972864.1| ABC transporter, ATP-binding/permea... 239 3e-61
gi|45552437|ref|NP_995741.1| CG9270-PB [Drosophila melanogaster]... 239 3e-61
gi|22298505|ref|NP_681752.1| ABC transporter ATP-binding protein... 239 4e-61
gi|15964873|ref|NP_385226.1| PROBABLE ABC TRANSPORTER ATP-BINDIN... 239 4e-61
gi|16759854|ref|NP_455471.1| probable transport ATP-binding prot... 239 4e-61
gi|15613688|ref|NP_241991.1| ABC transporter (ATP-binding protei... 239 4e-61
gi|46908931|ref|YP_015320.1| ABC transporter, ATP-binding/permea... 239 5e-61
gi|25150042|ref|NP_741273.1| heavy Metal Tolerance protein HMT-1... 239 5e-61
gi|33321257|gb|AAQ06435.1| ABC6 protein [Caenorhabditis elegans] 239 5e-61
gi|46311693|ref|ZP_00212296.1| COG1132: ABC-type multidrug trans... 239 5e-61
gi|19703933|ref|NP_603495.1| Phospholipid-lipopolysaccharide ABC... 239 5e-61
gi|24585091|ref|NP_724148.1| CG31792-PA [Drosophila melanogaster... 239 5e-61
gi|7509182|pir||T26313 hypothetical protein W09D6.6 - Caenorhabd... 239 5e-61
gi|23467052|ref|ZP_00122637.1| COG1132: ABC-type multidrug trans... 239 5e-61
gi|50121481|ref|YP_050648.1| lipid a export ATP-binding/permease... 239 5e-61
gi|15894891|ref|NP_348240.1| ABC-type multidrug/protein/lipid tr... 238 6e-61
gi|47095552|ref|ZP_00233161.1| ABC transporter, ATP-binding/perm... 238 6e-61
gi|21305105|gb|AAM45567.1| AqxB [Actinobacillus cf. equuli] 238 6e-61
gi|39937052|ref|NP_949328.1| putative ABC transporter ATP-bindin... 238 6e-61
gi|39584733|emb|CAE67628.1| Hypothetical protein CBG13182 [Caeno... 238 6e-61
gi|24374337|ref|NP_718380.1| ABC transporter, ATP-binding protei... 238 6e-61
gi|1708223|sp|P55122|HLYB_PASSP Leukotoxin secretion/processing ... 238 8e-61
gi|7445809|pir||S72637 hypothetical ABC exporter component A - T... 238 8e-61
gi|23111716|ref|ZP_00097309.1| COG1132: ABC-type multidrug trans... 238 8e-61
gi|15987896|gb|AAL12770.1| LktB [Mannheimia haemolytica] 238 1e-60
>gi|17569907|ref|NP_509813.1| P-GlycoProtein related (pgp-6)
[Caenorhabditis elegans]
gi|6425208|emb|CAA94220.2| Hypothetical protein T21E8.1
[Caenorhabditis elegans]
Length = 1225
Score = 2369 bits (6139), Expect = 0.0
Identities = 1210/1225 (98%), Positives = 1210/1225 (98%)
Frame = -1
Query: 3678 MEENSNNFSTPLLPQSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFM 3499
MEENSNNFSTPLLPQSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFM
Sbjct: 1 MEENSNNFSTPLLPQSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFM 60
Query: 3498 SYTFGEVSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQ 3319
SYTFGEVSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQ
Sbjct: 61 SYTFGEVSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQ 120
Query: 3318 HAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIAL 3139
HAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIAL
Sbjct: 121 HAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIAL 180
Query: 3138 IIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGS 2959
IIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGS
Sbjct: 181 IIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGS 240
Query: 2958 IAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTV 2779
IAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTV
Sbjct: 241 IAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTV 300
Query: 2778 VLYVGATMIYSGTLETAVVVRDDNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQV 2599
VLYVGATMIYSGTLETAVVVRDDNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQV
Sbjct: 301 VLYVGATMIYSGTLETAVVVRDDNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQV 360
Query: 2598 LKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRV 2419
LKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRV
Sbjct: 361 LKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRV 420
Query: 2418 IGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGT 2239
IGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGT
Sbjct: 421 IGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGT 480
Query: 2238 QLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRL 2059
QLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRL
Sbjct: 481 QLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRL 540
Query: 2058 STIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLESHDDHEELPPLAARQLS 1879
STIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLESHDDHEELPPLAARQLS
Sbjct: 541 STIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLESHDDHEELPPLAARQLS 600
Query: 1878 QELSPLHSYAIQRSTSNDAGVHDDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIA 1699
QELSPLHSYAIQRSTSNDAGVHDDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIA
Sbjct: 601 QELSPLHSYAIQRSTSNDAGVHDDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIA 660
Query: 1698 VFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYY 1519
VFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYY
Sbjct: 661 VFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYY 720
Query: 1518 FGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCV 1339
FGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCV
Sbjct: 721 FGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCV 780
Query: 1338 IMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRT 1159
IMTVVAISIAITTASLYCWKMTLEVLMFFP AIQEDTIAFENSNRT
Sbjct: 781 IMTVVAISIAITTASLYCWKMTLEVLMFFPLLYLAEYCYEAATETAIQEDTIAFENSNRT 840
Query: 1158 AIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVS 979
AIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVS
Sbjct: 841 AIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVS 900
Query: 978 FKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPA 799
FKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPA
Sbjct: 901 FKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPA 960
Query: 798 TMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKS 619
TMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKS
Sbjct: 961 TMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKS 1020
Query: 618 TIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTR 439
TIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTR
Sbjct: 1021 TIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTR 1080
Query: 438 SVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLL 259
SVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLL
Sbjct: 1081 SVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLL 1140
Query: 258 LDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHE 79
LDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHE
Sbjct: 1141 LDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHE 1200
Query: 78 ELLRKRSIYWRLVQKQGIQVETPSD 4
ELLRKRSIYWRLVQKQGIQVETPSD
Sbjct: 1201 ELLRKRSIYWRLVQKQGIQVETPSD 1225
>gi|50507726|emb|CAA94219.3| Hypothetical protein T21E8.2
[Caenorhabditis elegans]
Length = 1263
Score = 2269 bits (5880), Expect = 0.0
Identities = 1158/1263 (91%), Positives = 1190/1263 (93%), Gaps = 38/1263 (3%)
Frame = -1
Query: 3678 MEENSNNFSTPLLPQSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFM 3499
MEE+SN+++TPL+ QS+EKKP ++CSFIRV+FKC+SCFEKFLFL+GV FSL+TG CQPF+
Sbjct: 1 MEESSNDYTTPLIAQSNEKKPLELCSFIRVIFKCTSCFEKFLFLIGVFFSLVTGLCQPFV 60
Query: 3498 SYTFGEVSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQ 3319
SYT GE +QVLVTITNAINNKTIDPADL+KAYE+YERGM QVV +FFLCGCAYF FAS+Q
Sbjct: 61 SYTLGETAQVLVTITNAINNKTIDPADLKKAYEQYERGMYQVVLYFFLCGCAYFTFASIQ 120
Query: 3318 HAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIAL 3139
HAIMKYVGDNTTYRVRKQYISRLL+KDA+YFD+VSTGHLSTVLNDNLERFREVFNEKIAL
Sbjct: 121 HAIMKYVGDNTTYRVRKQYISRLLRKDAEYFDNVSTGHLSTVLNDNLERFREVFNEKIAL 180
Query: 3138 IIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGS 2959
I A +TDF +GTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGS
Sbjct: 181 IFALLTDFVVGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGS 240
Query: 2958 IAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTV 2779
IAFQTLGAYKTVCSLNGQ TEIERYTEELKAGEKYGI RALMYSISRG TYFFCNSLNTV
Sbjct: 241 IAFQTLGAYKTVCSLNGQNTEIERYTEELKAGEKYGIHRALMYSISRGFTYFFCNSLNTV 300
Query: 2778 VLYVGATMIYSGTLETAVVVR--------------------------------------D 2713
+LYVGA MIYSG+LE AVVVR +
Sbjct: 301 ILYVGANMIYSGSLEPAVVVRIFHYMMFGAFCLSEALPHISRLAGAISSTAPIAEMLIKE 360
Query: 2712 DNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGS 2533
DNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGS
Sbjct: 361 DNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGS 420
Query: 2532 GKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFG 2353
GKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFG
Sbjct: 421 GKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFG 480
Query: 2352 NPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKI 2173
NPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKI
Sbjct: 481 NPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKI 540
Query: 2172 LLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGN 1993
LLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGN
Sbjct: 541 LLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGN 600
Query: 1992 HDELIAKRGVYNDLVQAQLLESHDDHEELPPLAARQLSQELSPLHSYAIQRSTSNDAGVH 1813
HDELIAKRGVYNDLVQAQLLESHDDHEELPPLAARQLSQELSPLHSYAIQRSTSNDAGVH
Sbjct: 601 HDELIAKRGVYNDLVQAQLLESHDDHEELPPLAARQLSQELSPLHSYAIQRSTSNDAGVH 660
Query: 1812 DDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTY 1633
DDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTY
Sbjct: 661 DDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTY 720
Query: 1632 EGFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLS 1453
EGFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLS
Sbjct: 721 EGFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLS 780
Query: 1452 LPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMT 1273
LPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMT
Sbjct: 781 LPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMT 840
Query: 1272 LEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMS 1093
LEVL+FFP +IQEDTIAFENSNRTAIEALEN+RTVRALNLEDKIMS
Sbjct: 841 LEVLIFFPLLYLAEYCYDAATETSIQEDTIAFENSNRTAIEALENMRTVRALNLEDKIMS 900
Query: 1092 LISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVL 913
LISEHLQKIHKSYFKRAIIQGAANGLSLSC+LFVYSVSFKFGTYLALRKEVAPMDTYL+L
Sbjct: 901 LISEHLQKIHKSYFKRAIIQGAANGLSLSCYLFVYSVSFKFGTYLALRKEVAPMDTYLIL 960
Query: 912 MTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGEN 733
TLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGEN
Sbjct: 961 ETLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGEN 1020
Query: 732 VQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSE 553
VQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSE
Sbjct: 1021 VQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSE 1080
Query: 552 NVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQ 373
NVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQ
Sbjct: 1081 NVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQ 1140
Query: 372 FPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDT 193
FPQGLDT+VGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDT
Sbjct: 1141 FPQGLDTIVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDT 1200
Query: 192 ASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQVET 13
ASERLSTVVVAHRL TVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQVET
Sbjct: 1201 ASERLSTVVVAHRLLTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQVET 1260
Query: 12 PSD 4
P D
Sbjct: 1261 PYD 1263
>gi|17569909|ref|NP_509812.1| P-GlycoProtein related (pgp-7)
[Caenorhabditis elegans]
Length = 1269
Score = 2263 bits (5863), Expect = 0.0
Identities = 1158/1269 (91%), Positives = 1190/1269 (93%), Gaps = 44/1269 (3%)
Frame = -1
Query: 3678 MEENSNNFSTPLLPQSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFM 3499
MEE+SN+++TPL+ QS+EKKP ++CSFIRV+FKC+SCFEKFLFL+GV FSL+TG CQPF+
Sbjct: 1 MEESSNDYTTPLIAQSNEKKPLELCSFIRVIFKCTSCFEKFLFLIGVFFSLVTGLCQPFV 60
Query: 3498 SYTFGEVSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQ 3319
SYT GE +QVLVTITNAINNKTIDPADL+KAYE+YERGM QVV +FFLCGCAYF FAS+Q
Sbjct: 61 SYTLGETAQVLVTITNAINNKTIDPADLKKAYEQYERGMYQVVLYFFLCGCAYFTFASIQ 120
Query: 3318 HAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIAL 3139
HAIMKYVGDNTTYRVRKQYISRLL+KDA+YFD+VSTGHLSTVLNDNLERFREVFNEKIAL
Sbjct: 121 HAIMKYVGDNTTYRVRKQYISRLLRKDAEYFDNVSTGHLSTVLNDNLERFREVFNEKIAL 180
Query: 3138 IIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGS 2959
I A +TDF +GTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGS
Sbjct: 181 IFALLTDFVVGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGS 240
Query: 2958 IAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTV 2779
IAFQTLGAYKTVCSLNGQ TEIERYTEELKAGEKYGI RALMYSISRG TYFFCNSLNTV
Sbjct: 241 IAFQTLGAYKTVCSLNGQNTEIERYTEELKAGEKYGIHRALMYSISRGFTYFFCNSLNTV 300
Query: 2778 VLYVGATMIYSGTLETAVVVR--------------------------------------D 2713
+LYVGA MIYSG+LE AVVVR +
Sbjct: 301 ILYVGANMIYSGSLEPAVVVRIFHYMMFGAFCLSEALPHISRLAGAISSTAPIAEMLIKE 360
Query: 2712 DNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGS 2533
DNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGS
Sbjct: 361 DNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGS 420
Query: 2532 GKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFG 2353
GKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFG
Sbjct: 421 GKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFG 480
Query: 2352 NPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKI 2173
NPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKI
Sbjct: 481 NPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKI 540
Query: 2172 LLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGN 1993
LLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGN
Sbjct: 541 LLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGN 600
Query: 1992 HDELIAKRGVYNDLVQAQLLESHDDHEELPPLAARQLSQELSPLHSYAIQRSTSNDAGVH 1813
HDELIAKRGVYNDLVQAQLLESHDDHEELPPLAARQLSQELSPLHSYAIQRSTSNDAGVH
Sbjct: 601 HDELIAKRGVYNDLVQAQLLESHDDHEELPPLAARQLSQELSPLHSYAIQRSTSNDAGVH 660
Query: 1812 DDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTY 1633
DDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTY
Sbjct: 661 DDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTY 720
Query: 1632 EGFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLS 1453
EGFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLS
Sbjct: 721 EGFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLS 780
Query: 1452 LPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMT 1273
LPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMT
Sbjct: 781 LPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMT 840
Query: 1272 LEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMS 1093
LEVL+FFP +IQEDTIAFENSNRTAIEALEN+RTVRALNLEDKIMS
Sbjct: 841 LEVLIFFPLLYLAEYCYDAATETSIQEDTIAFENSNRTAIEALENMRTVRALNLEDKIMS 900
Query: 1092 LISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVL 913
LISEHLQKIHKSYFKRAIIQGAANGLSLSC+LFVYSVSFKFGTYLALRKEVAPMDTYL+L
Sbjct: 901 LISEHLQKIHKSYFKRAIIQGAANGLSLSCYLFVYSVSFKFGTYLALRKEVAPMDTYLIL 960
Query: 912 MTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGEN 733
TLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGEN
Sbjct: 961 ETLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGEN 1020
Query: 732 VQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEV----- 568
VQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEV
Sbjct: 1021 VQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVVSIDA 1080
Query: 567 -KIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANA 391
KIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANA
Sbjct: 1081 HKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANA 1140
Query: 390 FNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVV 211
FNFVFQFPQGLDT+VGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVV
Sbjct: 1141 FNFVFQFPQGLDTIVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVV 1200
Query: 210 QNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
QNALDTASERLSTVVVAHRL TVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ
Sbjct: 1201 QNALDTASERLSTVVVAHRLLTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 1260
Query: 30 GIQVETPSD 4
GIQVETP D
Sbjct: 1261 GIQVETPYD 1269
>gi|7508147|pir||T25083 hypothetical protein T21E8.1 - Caenorhabditis
elegans
Length = 1114
Score = 2145 bits (5558), Expect = 0.0
Identities = 1090/1105 (98%), Positives = 1090/1105 (98%)
Frame = -1
Query: 3678 MEENSNNFSTPLLPQSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFM 3499
MEENSNNFSTPLLPQSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFM
Sbjct: 1 MEENSNNFSTPLLPQSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFM 60
Query: 3498 SYTFGEVSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQ 3319
SYTFGEVSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQ
Sbjct: 61 SYTFGEVSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQ 120
Query: 3318 HAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIAL 3139
HAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIAL
Sbjct: 121 HAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIAL 180
Query: 3138 IIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGS 2959
IIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGS
Sbjct: 181 IIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGS 240
Query: 2958 IAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTV 2779
IAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTV
Sbjct: 241 IAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTV 300
Query: 2778 VLYVGATMIYSGTLETAVVVRDDNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQV 2599
VLYVGATMIYSGTLETAVVVRDDNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQV
Sbjct: 301 VLYVGATMIYSGTLETAVVVRDDNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQV 360
Query: 2598 LKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRV 2419
LKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRV
Sbjct: 361 LKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRV 420
Query: 2418 IGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGT 2239
IGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGT
Sbjct: 421 IGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGT 480
Query: 2238 QLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRL 2059
QLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRL
Sbjct: 481 QLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRL 540
Query: 2058 STIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLESHDDHEELPPLAARQLS 1879
STIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLESHDDHEELPPLAARQLS
Sbjct: 541 STIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLESHDDHEELPPLAARQLS 600
Query: 1878 QELSPLHSYAIQRSTSNDAGVHDDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIA 1699
QELSPLHSYAIQRSTSNDAGVHDDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIA
Sbjct: 601 QELSPLHSYAIQRSTSNDAGVHDDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIA 660
Query: 1698 VFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYY 1519
VFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYY
Sbjct: 661 VFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYY 720
Query: 1518 FGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCV 1339
FGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCV
Sbjct: 721 FGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCV 780
Query: 1338 IMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRT 1159
IMTVVAISIAITTASLYCWKMTLEVLMFFP AIQEDTIAFENSNRT
Sbjct: 781 IMTVVAISIAITTASLYCWKMTLEVLMFFPLLYLAEYCYEAATETAIQEDTIAFENSNRT 840
Query: 1158 AIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVS 979
AIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVS
Sbjct: 841 AIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVS 900
Query: 978 FKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPA 799
FKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPA
Sbjct: 901 FKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPA 960
Query: 798 TMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKS 619
TMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKS
Sbjct: 961 TMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKS 1020
Query: 618 TIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTR 439
TIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTR
Sbjct: 1021 TIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTR 1080
Query: 438 SVPQLELEKALQTANAFNFVFQFPQ 364
SVPQLELEKALQTANAFNFVFQFPQ
Sbjct: 1081 SVPQLELEKALQTANAFNFVFQFPQ 1105
Score = 264 bits (674), Expect = 1e-68
Identities = 170/518 (32%), Positives = 260/518 (49%), Gaps = 9/518 (1%)
Frame = -1
Query: 1557 VFRPLTLYCQYYYFGK--------VSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLS 1402
VF C Y+ F V + + R+R + S +L ++D S LS
Sbjct: 103 VFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSV--STGHLS 160
Query: 1401 NRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXX 1222
LN + + ++++ +I V ++ A W++ + F
Sbjct: 161 TVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFIN 220
Query: 1221 XXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRA 1042
+ + N+ A + L +TV +LN + + +E L+ K +RA
Sbjct: 221 SAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRA 280
Query: 1041 IIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYL 862
++ + G+ TY +L+ G+ Y
Sbjct: 281 LMYSISRGV-----------------------------TYFFCNSLNTVVLYVGATMIYS 311
Query: 861 PDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIE-KGEIIGENVQFHYDQRPDRMILNG 685
+ AV + + +D +E G I +NV+F Y RPD +L G
Sbjct: 312 GTLETAV--------VVRDDNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKG 363
Query: 684 VNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLAL 505
++ V G+ +ALVG SG GKST++ LL +Y+ G + ID ++ D+N+ LR + +
Sbjct: 364 ISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGV 423
Query: 504 VSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQL 325
VSQEP LFN +I EN+ +G +V E+ AL+ ANA++FV FP+G+ T+VGERG QL
Sbjct: 424 VSQEPVLFNTTIEENIRFG-NPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQL 482
Query: 324 SGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLST 145
SGGQKQRIAIAR ++RNPK+LLLDEATSALD++SE+VVQ AL+ AS+ +T+VVAHRLST
Sbjct: 483 SGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLST 542
Query: 144 VVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
+ NA I V++ G++ E G H+EL+ KR +Y LVQ Q
Sbjct: 543 IRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQ 580
>gi|39594939|emb|CAE70807.1| Hypothetical protein CBG17569
[Caenorhabditis briggsae]
Length = 1224
Score = 2093 bits (5422), Expect = 0.0
Identities = 1049/1225 (85%), Positives = 1129/1225 (91%)
Frame = -1
Query: 3678 MEENSNNFSTPLLPQSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFM 3499
MEENSNN STPLL + +KK S + SFIRV+FKC+SCFEK LF+LG+ FSL+TG CQPFM
Sbjct: 1 MEENSNNSSTPLLHEESQKKSSPLLSFIRVIFKCTSCFEKLLFMLGIFFSLLTGLCQPFM 60
Query: 3498 SYTFGEVSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQ 3319
SYTFGEVSQVLVTITNAINNKTIDPADLEKAYE +ER MN V+ HFF CGCAYF F SLQ
Sbjct: 61 SYTFGEVSQVLVTITNAINNKTIDPADLEKAYEVFERDMNSVILHFFFCGCAYFTFGSLQ 120
Query: 3318 HAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIAL 3139
+IMK+VGDNTTYRVRKQYISRLL+KDA+YFDS+STGHLST+LNDNLERFREVFNEKIAL
Sbjct: 121 FSIMKFVGDNTTYRVRKQYISRLLRKDARYFDSMSTGHLSTILNDNLERFREVFNEKIAL 180
Query: 3138 IIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGS 2959
IIAF TDFT+GTALAFYTDWRLASYGI FSLGIAFSG INSA +MK T KQN HYANAGS
Sbjct: 181 IIAFATDFTVGTALAFYTDWRLASYGIVFSLGIAFSGLINSASMMKNTDKQNAHYANAGS 240
Query: 2958 IAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTV 2779
IAFQ LGAYKTVCSLNGQ+ EIERYT+ELK GEKYG+ RAL YSISRGVTYFFCN+LNTV
Sbjct: 241 IAFQ-LGAYKTVCSLNGQRQEIERYTKELKEGEKYGLYRALFYSISRGVTYFFCNALNTV 299
Query: 2778 VLYVGATMIYSGTLETAVVVRDDNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQV 2599
VLY GA MIY GTL+T VVRDDN IE+DE D + V+V GNISFK+VKFSYP RPDAQV
Sbjct: 300 VLYFGANMIYDGTLDTGTVVRDDNEIERDEEDCEDGVDVQGNISFKDVKFSYPIRPDAQV 359
Query: 2598 LKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRV 2419
LKGISFDV+NGECIALVGASGSGKSTVVQLLLHYYNI+SGNI IDG++LN +N+K+LRRV
Sbjct: 360 LKGISFDVKNGECIALVGASGSGKSTVVQLLLHYYNIESGNILIDGVELNKINLKKLRRV 419
Query: 2418 IGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGT 2239
IGVVSQEPVLFNTTIEENIRFGN +LPEIYGALRKANAYDFVC+FPKGIKTIVGERGT
Sbjct: 420 IGVVSQEPVLFNTTIEENIRFGNSEATLPEIYGALRKANAYDFVCAFPKGIKTIVGERGT 479
Query: 2238 QLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRL 2059
QLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESE VVQKALENASQGRTTIVVAHRL
Sbjct: 480 QLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEHVVQKALENASQGRTTIVVAHRL 539
Query: 2058 STIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLESHDDHEELPPLAARQLS 1879
STIRNA+KIIVMQKGEIVEVGNHDELI+K+G YNDLVQAQLL SHDDH ELPPL ARQLS
Sbjct: 540 STIRNANKIIVMQKGEIVEVGNHDELISKQGAYNDLVQAQLLNSHDDHNELPPLTARQLS 599
Query: 1878 QELSPLHSYAIQRSTSNDAGVHDDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIA 1699
ELSPLHSY+ QRSTS DAGVHDDDMER+LDEL++EGAKKSNLREIVK CRPDYC LF+A
Sbjct: 600 HELSPLHSYSFQRSTSTDAGVHDDDMERLLDELTQEGAKKSNLREIVKMCRPDYCILFLA 659
Query: 1698 VFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYY 1519
VFGSAIQG+SYPILAQLIVRTY+G+AM GED+L Y H WALSFMFLAVFRPLTLY QYYY
Sbjct: 660 VFGSAIQGISYPILAQLIVRTYQGYAMHGEDILTYGHFWALSFMFLAVFRPLTLYLQYYY 719
Query: 1518 FGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCV 1339
FGKV+E+LSTRLR+KSF HMLSLP AFYDDP HSAT+LSNRLNTDSSNVKAAVDDRLGCV
Sbjct: 720 FGKVAEKLSTRLRVKSFKHMLSLPSAFYDDPKHSATKLSNRLNTDSSNVKAAVDDRLGCV 779
Query: 1338 IMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRT 1159
IMT+VAISIA+ TA+ YCWKMTLEVLMFFP AIQED+IAFENSNRT
Sbjct: 780 IMTLVAISIAVITAANYCWKMTLEVLMFFPLLYLAEYCYEAATENAIQEDSIAFENSNRT 839
Query: 1158 AIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVS 979
AIEALENVRTVRALNLEDK+MS I+ HLQKIH SYFKRAIIQGAANGLS+SCFLFVYS+S
Sbjct: 840 AIEALENVRTVRALNLEDKVMSSITNHLQKIHNSYFKRAIIQGAANGLSMSCFLFVYSIS 899
Query: 978 FKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPA 799
FKFG YLALRKEV PM+TYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIF++FTYPA
Sbjct: 900 FKFGVYLALRKEVEPMNTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFNMFTYPA 959
Query: 798 TMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKS 619
TMP+ SSDG+KNIEKGEI+GEN+QFHYDQRPDRMILNGVNLKV+PGKTLALVGPSGCGKS
Sbjct: 960 TMPYDSSDGRKNIEKGEIVGENLQFHYDQRPDRMILNGVNLKVEPGKTLALVGPSGCGKS 1019
Query: 618 TIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTR 439
TIISLLERFYH +GE+KID ENVEDINL+HLR+N+ALVSQEPTLFNCSIRENLLYGLTR
Sbjct: 1020 TIISLLERFYHVTNGEIKIDRENVEDINLHHLRANIALVSQEPTLFNCSIRENLLYGLTR 1079
Query: 438 SVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLL 259
VPQLE+EKALQTANAF+FV+QFPQGLDT+VGERGAQLSGGQKQRIAIARAILRNPKVLL
Sbjct: 1080 QVPQLEIEKALQTANAFHFVYQFPQGLDTIVGERGAQLSGGQKQRIAIARAILRNPKVLL 1139
Query: 258 LDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHE 79
LDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHE
Sbjct: 1140 LDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHE 1199
Query: 78 ELLRKRSIYWRLVQKQGIQVETPSD 4
ELLR RS+YW LVQKQG+ V+ PSD
Sbjct: 1200 ELLRLRSVYWGLVQKQGMHVQAPSD 1224
>gi|7508148|pir||T25082 hypothetical protein T21E8.2 - Caenorhabditis
elegans
Length = 1158
Score = 2044 bits (5296), Expect = 0.0
Identities = 1041/1149 (90%), Positives = 1072/1149 (92%), Gaps = 44/1149 (3%)
Frame = -1
Query: 3678 MEENSNNFSTPLLPQSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFM 3499
MEE+SN+++TPL+ QS+EKKP ++CSFIRV+FKC+SCFEKFLFL+GV FSL+TG CQPF+
Sbjct: 1 MEESSNDYTTPLIAQSNEKKPLELCSFIRVIFKCTSCFEKFLFLIGVFFSLVTGLCQPFV 60
Query: 3498 SYTFGEVSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQ 3319
SYT GE +QVLVTITNAINNKTIDPADL+KAYE+YERGM QVV +FFLCGCAYF FAS+Q
Sbjct: 61 SYTLGETAQVLVTITNAINNKTIDPADLKKAYEQYERGMYQVVLYFFLCGCAYFTFASIQ 120
Query: 3318 HAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIAL 3139
HAIMKYVGDNTTYRVRKQYISRLL+KDA+YFD+VSTGHLSTVLNDNLERFREVFNEKIAL
Sbjct: 121 HAIMKYVGDNTTYRVRKQYISRLLRKDAEYFDNVSTGHLSTVLNDNLERFREVFNEKIAL 180
Query: 3138 IIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGS 2959
I A +TDF +GTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGS
Sbjct: 181 IFALLTDFVVGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGS 240
Query: 2958 IAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTV 2779
IAFQTLGAYKTVCSLNGQ TEIERYTEELKAGEKYGI RALMYSISRG TYFFCNSLNTV
Sbjct: 241 IAFQTLGAYKTVCSLNGQNTEIERYTEELKAGEKYGIHRALMYSISRGFTYFFCNSLNTV 300
Query: 2778 VLYVGATMIYSGTLETAVVVR--------------------------------------D 2713
+LYVGA MIYSG+LE AVVVR +
Sbjct: 301 ILYVGANMIYSGSLEPAVVVRIFHYMMFGAFCLSEALPHISRLAGAISSTAPIAEMLIKE 360
Query: 2712 DNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGS 2533
DNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGS
Sbjct: 361 DNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGS 420
Query: 2532 GKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFG 2353
GKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFG
Sbjct: 421 GKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFG 480
Query: 2352 NPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKI 2173
NPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKI
Sbjct: 481 NPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKI 540
Query: 2172 LLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGN 1993
LLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGN
Sbjct: 541 LLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGN 600
Query: 1992 HDELIAKRGVYNDLVQAQLLESHDDHEELPPLAARQLSQELSPLHSYAIQRSTSNDAGVH 1813
HDELIAKRGVYNDLVQAQLLESHDDHEELPPLAARQLSQELSPLHSYAIQRSTSNDAGVH
Sbjct: 601 HDELIAKRGVYNDLVQAQLLESHDDHEELPPLAARQLSQELSPLHSYAIQRSTSNDAGVH 660
Query: 1812 DDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTY 1633
DDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTY
Sbjct: 661 DDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTY 720
Query: 1632 EGFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLS 1453
EGFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLS
Sbjct: 721 EGFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLS 780
Query: 1452 LPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMT 1273
LPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMT
Sbjct: 781 LPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMT 840
Query: 1272 LEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMS 1093
LEVL+FFP +IQEDTIAFENSNRTAIEALEN+RTVRALNLEDKIMS
Sbjct: 841 LEVLIFFPLLYLAEYCYDAATETSIQEDTIAFENSNRTAIEALENMRTVRALNLEDKIMS 900
Query: 1092 LISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVL 913
LISEHLQKIHKSYFKRAIIQGAANGLSLSC+LFVYSVSFKFGTYLALRKEVAPMDTYL+L
Sbjct: 901 LISEHLQKIHKSYFKRAIIQGAANGLSLSCYLFVYSVSFKFGTYLALRKEVAPMDTYLIL 960
Query: 912 MTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGEN 733
TLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGEN
Sbjct: 961 ETLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGEN 1020
Query: 732 VQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEV----- 568
VQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEV
Sbjct: 1021 VQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVVSIDA 1080
Query: 567 -KIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANA 391
KIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANA
Sbjct: 1081 HKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANA 1140
Query: 390 FNFVFQFPQ 364
FNFVFQFPQ
Sbjct: 1141 FNFVFQFPQ 1149
Score = 269 bits (688), Expect = 3e-70
Identities = 186/597 (31%), Positives = 293/597 (48%), Gaps = 21/597 (3%)
Frame = -1
Query: 1758 SNLREIVK--QCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDM------ 1603
S +R I K C + FL I VF S + G+ P ++ + T + I +
Sbjct: 26 SFIRVIFKCTSCFEKFLFL-IGVFFSLVTGLCQPFVSYTLGETAQVLVTITNAINNKTID 84
Query: 1602 ---LYYSHLWALSFMFLAVFRPLTLYCQYYYFGK--------VSEQLSTRLRIKSFSHML 1456
L ++ M+ V C Y+ F V + + R+R + S +L
Sbjct: 85 PADLKKAYEQYERGMYQVVLYFFLCGCAYFTFASIQHAIMKYVGDNTTYRVRKQYISRLL 144
Query: 1455 SLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKM 1276
++D N S LS LN + + ++++ + + + A W++
Sbjct: 145 RKDAEYFD--NVSTGHLSTVLNDNLERFREVFNEKIALIFALLTDFVVGTALAFYTDWRL 202
Query: 1275 TLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIM 1096
+ F + + N+ A + L +TV +LN ++ +
Sbjct: 203 ASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQNTEI 262
Query: 1095 SLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLV 916
+E L+ K RA++ + G + + +V G + + P +
Sbjct: 263 ERYTEELKAGEKYGIHRALMYSISRGFTYFFCNSLNTVILYVGANMIYSGSLEPAVVVRI 322
Query: 915 LMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFH-LFTYPATMPFSSSDGKKNIE-KGEII 742
+ A A ++ A+ + I L + +D +E G I
Sbjct: 323 FHYMMFGAFCLSEALPHISRLAGAISSTAPIAEMLIKEDNVIEKDETDYDVEVEVNGNIS 382
Query: 741 GENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKI 562
+NV+F Y RPD +L G++ V G+ +ALVG SG GKST++ LL +Y+ G + I
Sbjct: 383 FKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFI 442
Query: 561 DSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNF 382
D ++ D+N+ LR + +VSQEP LFN +I EN+ +G +V E+ AL+ ANA++F
Sbjct: 443 DGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFG-NPNVSLPEIYGALRKANAYDF 501
Query: 381 VFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNA 202
V FP+G+ T+VGERG QLSGGQKQRIAIAR ++RNPK+LLLDEATSALD++SE+VVQ A
Sbjct: 502 VCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKA 561
Query: 201 LDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
L+ AS+ +T+VVAHRLST+ NA I V++ G++ E G H+EL+ KR +Y LVQ Q
Sbjct: 562 LENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQ 618
>gi|17550138|ref|NP_509810.1| P-GlycoProtein related (pgp-5)
[Caenorhabditis elegans]
gi|7495402|pir||T18939 hypothetical protein C05A9.1 - Caenorhabditis
elegans
gi|3874030|emb|CAA94202.1| Hypothetical protein C05A9.1
[Caenorhabditis elegans]
Length = 1283
Score = 1609 bits (4166), Expect = 0.0
Identities = 833/1267 (65%), Positives = 985/1267 (76%), Gaps = 53/1267 (4%)
Frame = -1
Query: 3654 STPLLPQSDEKKPSQICSFIRVV---------------FKCSSCFEKFLFLLGVLFSLMT 3520
S PLLP S S +C FI+V+ KC++ +EK LF LGV+FS++T
Sbjct: 19 SFPLLPFSSNTNWSNVCKFIKVIVGSTNNFLKKTFGFQIKCTTRYEKLLFFLGVVFSILT 78
Query: 3519 GFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAY 3340
G CQPF SYT GE SQVLV +TNAINNKTIDP DL AY+ +E MN+VV FFL G AY
Sbjct: 79 GMCQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFESDMNRVVLLFFLVGFAY 138
Query: 3339 FIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREV 3160
F F LQ +IMK+VGDNT Y VR+QYISRLL+KD YFD +STGHLS VLNDN+ERFREV
Sbjct: 139 FTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMSTGHLSIVLNDNMERFREV 198
Query: 3159 FNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNT 2980
FNEKIALIIA +TDF +GT LAFYTDWRLA YG FS GI SG ++S G MK KQN
Sbjct: 199 FNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGLLDSWGKMKNNEKQNE 258
Query: 2979 HYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFF 2800
H +NAGSIAFQ LG YKTV SLNGQ+ E+ERYTEELK GEKY + RA ++S+SR YFF
Sbjct: 259 HISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNRAFVFSLSRSADYFF 318
Query: 2799 CNSLNTVVLYVGATMIYSGTLETAVVVR-------------------------------- 2716
N+LN V+LY GA MIY GT+E VVVR
Sbjct: 319 TNALNFVILYFGANMIYEGTIEPGVVVRILYYILFGSYCLGEAILHISRLASAIPLTVPI 378
Query: 2715 DDNVIEKDET-----DYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIAL 2551
D +++ D T +++ G ISFKNV FSYPTRPD VLK ISF+VQ GECIAL
Sbjct: 379 ADILLDSDATADEFFSEEIKDTFQGIISFKNVLFSYPTRPDVPVLKEISFNVQGGECIAL 438
Query: 2550 VGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIE 2371
VGASGSGKSTV+QLLLHYYNIDSG I IDG D+ ++NIK+LR+ +GVV QEPVLFNT+IE
Sbjct: 439 VGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAMGVVFQEPVLFNTSIE 498
Query: 2370 ENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTL 2191
ENIRFG P+ + EI AL+ ANA+DFVC+FP GIKTIVGERG QLSGGQKQRIAIARTL
Sbjct: 499 ENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGERGAQLSGGQKQRIAIARTL 558
Query: 2190 VRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGE 2011
VRNP+ILLLDEATSALDNESE +VQ+AL+ AS GRTTIVVAHRLSTIRNA+KIIVM+KGE
Sbjct: 559 VRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHRLSTIRNANKIIVMEKGE 618
Query: 2010 IVEVGNHDELIAKRGVYNDLVQAQLLES-HDDHEELPPLAARQLSQELSPLHSYAIQRST 1834
IVEVG+H +LIA GVYN+LVQ QL+ + ++ E RQ S P + + Q+
Sbjct: 619 IVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNENEERVTRQSSHSDFPSNEISHQKID 678
Query: 1833 SNDAGVHDDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILA 1654
D D +++++ E+ +EGAKKSN+ EI+K CR +YC LFIAV GSAIQG+ YP+ +
Sbjct: 679 QED-----DYVKKLIAEIKEEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSS 733
Query: 1653 QLIVRTYEGFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIK 1474
QL++++YE +A ++ML SH WALS +FLA RP+ ++ QYY+FGK +E+LS +LR
Sbjct: 734 QLMIKSYEAYAFDKDEMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLRSM 793
Query: 1473 SFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTAS 1294
SF H++SLPCAFYDDP H+ATRLSNRLN DSSNV AAVDDRLG VIMT+VAI +A+ +
Sbjct: 794 SFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAVIMSF 853
Query: 1293 LYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALN 1114
Y WKM+L+VLMF P A++ED+IAFE SNR AIEALENVRTVRALN
Sbjct: 854 FYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALN 913
Query: 1113 LEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAP 934
+E++++ L++ HLQKI SYFKRA+IQG ANG + SC+ F+Y+VSFKFGT+L LR+E+ P
Sbjct: 914 MENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILP 973
Query: 933 MDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEK 754
MDTYLVLMTLSMTA+ AGSA AYLPD++KA+HAAGLIFHLFTYPA MP+ SS GK+NI+
Sbjct: 974 MDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGKRNIKN 1033
Query: 753 GEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDG 574
GEI +NV F Y QR D+MIL+GV+LK+ G+TLALVGPSG GKSTIISLLERFYHAVDG
Sbjct: 1034 GEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDG 1093
Query: 573 EVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTAN 394
EVKID ENV D+NL+HLR +++LVSQEP LFNCSI+EN L+G++ + QLE+++AL+ AN
Sbjct: 1094 EVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVAN 1153
Query: 393 AFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKV 214
AF+FV QFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKV
Sbjct: 1154 AFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKV 1213
Query: 213 VQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQK 34
VQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQK
Sbjct: 1214 VQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQK 1273
Query: 33 QGIQVET 13
QGIQVET
Sbjct: 1274 QGIQVET 1280
>gi|39594940|emb|CAE70808.1| Hypothetical protein CBG17570
[Caenorhabditis briggsae]
Length = 1402
Score = 1513 bits (3917), Expect = 0.0
Identities = 773/1251 (61%), Positives = 948/1251 (74%), Gaps = 39/1251 (3%)
Frame = -1
Query: 3678 MEENSNNFSTPLLPQSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFM 3499
ME N N+ LLP + K+ S SF RVV+KC+S EK LFLLG + ++ TG CQPF+
Sbjct: 1 MENNENDL---LLPAENVKEYSNFSSFARVVWKCTSKLEKLLFLLGTISAVCTGLCQPFL 57
Query: 3498 SYTFGEVSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQ 3319
SYTFGEVS V V IT+A+NN+T+DP++L++AYE + MNQVV +F L GCA+ +F Q
Sbjct: 58 SYTFGEVSHVFVRITSAVNNRTLDPSELDEAYEVFHNEMNQVVLYFALVGCAFAMFGFFQ 117
Query: 3318 HAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIAL 3139
++ KYVGDNTTYRVR++YISRLL+KDAQYFD+VSTG+LSTVLNDNLERFRE FNEKIA
Sbjct: 118 FSLFKYVGDNTTYRVRRKYISRLLQKDAQYFDTVSTGYLSTVLNDNLERFREAFNEKIAF 177
Query: 3138 IIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGS 2959
II F TDF +GT LAFYTDW+LASYG F+LGIAFSGFINSA +M +T KQNTHYANAG+
Sbjct: 178 IICFSTDFVIGTTLAFYTDWKLASYGSIFALGIAFSGFINSASMMGSTVKQNTHYANAGA 237
Query: 2958 IAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTV 2779
IAFQ L ++KTV SLNGQ E+ERY++ELKAGEKYG RRA + SR VT+FFCN+LN +
Sbjct: 238 IAFQALSSFKTVISLNGQAQELERYSKELKAGEKYGARRAFFLATSRSVTHFFCNALNGI 297
Query: 2778 VLYVGATMIYSGTLETAVVVR--------------------------------------D 2713
+LYVGA +IY+ T++ AV+V
Sbjct: 298 ILYVGADLIYNKTMDQAVIVTLFHYMLFSAFSLGEAFPHISYLSNAISSASPIFAVLISK 357
Query: 2712 DNVIEKDETDYDVEVE-VNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASG 2536
D++IE + D + + E + G+I F NVKFSYPTRP+AQ LKG++F+V+ GEC+ALVGASG
Sbjct: 358 DDIIENHQNDTERDSERIEGDIQFDNVKFSYPTRPEAQALKGVTFNVKKGECVALVGASG 417
Query: 2535 SGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRF 2356
SGKST+VQLLLHYYNI+SGNI ID +DLN +N+K+LR IGVVSQEPVLFNTTIEENIRF
Sbjct: 418 SGKSTIVQLLLHYYNIESGNILIDDVDLNKINLKKLRGNIGVVSQEPVLFNTTIEENIRF 477
Query: 2355 GNPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPK 2176
GNP S EIY +LR ANAYDFV SFPKGIKT+VGERGTQLSGGQKQRIAIAR LV+NPK
Sbjct: 478 GNPAASTLEIYDSLRVANAYDFVNSFPKGIKTVVGERGTQLSGGQKQRIAIARVLVKNPK 537
Query: 2175 ILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVG 1996
ILLLDEATSALDN+SE VV+ A++ AS+GRTTIV+AHRLSTI++ +IIVM G+ V G
Sbjct: 538 ILLLDEATSALDNQSEHVVRIAMKEASKGRTTIVIAHRLSTIQHCDRIIVMSHGKTVASG 597
Query: 1995 NHDELIAKRGVYNDLVQAQLLESHDDHEELPPLAARQLSQELSPLHSYAIQRSTSNDAGV 1816
HD+L+ VY DLVQAQ L S D S + +TS
Sbjct: 598 THDKLMENSIVYKDLVQAQSLNSED-----------------SVVEKSIKTIATSETKHP 640
Query: 1815 HDDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRT 1636
++++E L + +E S + +I+++CR C LF+AV GSAIQG S+PILAQLIVR
Sbjct: 641 TNEELEEELKDTPEEETMSSTIWQILRECRSHCCMLFLAVVGSAIQGFSFPILAQLIVRV 700
Query: 1635 YEGFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHML 1456
Y+ +AM GE +L H WA F+ L ++RP+TLYCQY++FGK+ E+LSTRLRIKSF H+L
Sbjct: 701 YKAYAMQGEAILVNGHFWASMFLVLGLYRPITLYCQYFFFGKIGEKLSTRLRIKSFQHLL 760
Query: 1455 SLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKM 1276
SLPCAFYDDP +S TRL+NRLNTD+SNVKAAVD RLG V+MT+V+ +AIT A Y WK+
Sbjct: 761 SLPCAFYDDPKNSPTRLANRLNTDASNVKAAVDARLGSVLMTLVSFIVAITIACYYSWKL 820
Query: 1275 TLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIM 1096
T++VL+FFP +I++D++AFE SN+ AIE L+N++TVR+LN+E K+M
Sbjct: 821 TIQVLLFFPVLYLSKYCYEKTTVLSIKQDSLAFEFSNKIAIEVLDNIKTVRSLNMEQKVM 880
Query: 1095 SLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLV 916
S+++ L+ + + Y KRA G A+G S C VY++SFKFGTYL L++EV PMD YL
Sbjct: 881 SMVTGQLEMLKRKYHKRAFFLGLASGFSAGCSQIVYALSFKFGTYLILQREVLPMDMYLA 940
Query: 915 LMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGE 736
L+TLS T+NMAGSA +YLPDYKKA+HAAGLIF+LFTYPAT P++S G NI +G + E
Sbjct: 941 LVTLSYTSNMAGSAISYLPDYKKALHAAGLIFNLFTYPATAPYNSDQGTTNISQGIVNAE 1000
Query: 735 NVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDS 556
NV+FHY QRPD ++L V+L ++PGKTLALVGPSG GKST ISLLE FY G + ID
Sbjct: 1001 NVKFHYHQRPDHLVLKNVDLHLEPGKTLALVGPSGSGKSTFISLLEMFYRVNTGHINIDH 1060
Query: 555 ENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVF 376
ENVE+INL+HLRSNLALVSQEP LFNCSIRENLLYGL LE AL+TANA+NFV
Sbjct: 1061 ENVENINLHHLRSNLALVSQEPILFNCSIRENLLYGLDGPESDQNLETALETANAYNFVS 1120
Query: 375 QFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALD 196
Q P GLDT+VGERGAQLSGGQKQR+AIARAILRNPK+LLLDEATSALDSDSEK+VQ ALD
Sbjct: 1121 QMPNGLDTIVGERGAQLSGGQKQRVAIARAILRNPKLLLLDEATSALDSDSEKLVQTALD 1180
Query: 195 TASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRL 43
TASERLST++VAHRLST+VNADSIAVLK GKV EQG+HEELL+ + YW+L
Sbjct: 1181 TASERLSTIIVAHRLSTIVNADSIAVLKMGKVVEQGSHEELLKLKGAYWKL 1231
Score = 269 bits (688), Expect = 3e-70
Identities = 178/543 (32%), Positives = 277/543 (50%), Gaps = 3/543 (0%)
Frame = -1
Query: 1635 YEGFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHML 1456
YE F ++ Y L +F F Q+ F V + + R+R K S +L
Sbjct: 89 YEVFHNEMNQVVLYFALVGCAFAMFGFF-------QFSLFKYVGDNTTYRVRRKYISRLL 141
Query: 1455 SLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKM 1276
++D S LS LN + + A ++++ +I I T A WK+
Sbjct: 142 QKDAQYFDTV--STGYLSTVLNDNLERFREAFNEKIAFIICFSTDFVIGTTLAFYTDWKL 199
Query: 1275 TLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIM 1096
+F + + + N+ A +AL + +TV +LN + + +
Sbjct: 200 ASYGSIFALGIAFSGFINSASMMGSTVKQNTHYANAGAIAFQALSSFKTVISLNGQAQEL 259
Query: 1095 SLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLV 916
S+ L+ K +RA + ++ + + G L K + +
Sbjct: 260 ERYSKELKAGEKYGARRAFFLATSRSVTHFFCNALNGIILYVGADLIYNKTMDQAVIVTL 319
Query: 915 LMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFH-LFTYPATMPFSSSDGKKNIEK--GEI 745
+ +A G A ++ A+ +A IF L + + +D +++ E+ G+I
Sbjct: 320 FHYMLFSAFSLGEAFPHISYLSNAISSASPIFAVLISKDDIIENHQNDTERDSERIEGDI 379
Query: 744 IGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVK 565
+NV+F Y RP+ L GV V G+ +ALVG SG GKSTI+ LL +Y+ G +
Sbjct: 380 QFDNVKFSYPTRPEAQALKGVTFNVKKGECVALVGASGSGKSTIVQLLLHYYNIESGNIL 439
Query: 564 IDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFN 385
ID ++ INL LR N+ +VSQEP LFN +I EN+ +G + LE+ +L+ ANA++
Sbjct: 440 IDDVDLNKINLKKLRGNIGVVSQEPVLFNTTIEENIRFG-NPAASTLEIYDSLRVANAYD 498
Query: 384 FVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQN 205
FV FP+G+ T+VGERG QLSGGQKQRIAIAR +++NPK+LLLDEATSALD+ SE VV+
Sbjct: 499 FVNSFPKGIKTVVGERGTQLSGGQKQRIAIARVLVKNPKILLLDEATSALDNQSEHVVRI 558
Query: 204 ALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGI 25
A+ AS+ +T+V+AHRLST+ + D I V+ +GK GTH++L+ +Y LVQ Q +
Sbjct: 559 AMKEASKGRTTIVIAHRLSTIQHCDRIIVMSHGKTVASGTHDKLMENSIVYKDLVQAQSL 618
Query: 24 QVE 16
E
Sbjct: 619 NSE 621
>gi|25146777|ref|NP_509811.2| P-GlycoProtein related (pgp-8)
[Caenorhabditis elegans]
gi|22265670|emb|CAA94203.2| Hypothetical protein T21E8.3
[Caenorhabditis elegans]
gi|22265925|emb|CAA94221.2| Hypothetical protein T21E8.3
[Caenorhabditis elegans]
Length = 1243
Score = 1505 bits (3896), Expect = 0.0
Identities = 757/1254 (60%), Positives = 954/1254 (75%), Gaps = 40/1254 (3%)
Frame = -1
Query: 3672 ENSNNFSTPLLPQSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSY 3493
ENS N L+P +EKK + F++VV++C+S +EKFLF++GV+ ++ TG QPFMSY
Sbjct: 2 ENSEN--DVLIPVENEKKTTNWTKFVKVVWQCTSKWEKFLFVIGVVSAICTGLTQPFMSY 59
Query: 3492 TFGEVSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHA 3313
TFGEVSQ V IT A+NN ++DP+DLEKAYE + MN VV HF L GCA+ F +Q +
Sbjct: 60 TFGEVSQAFVRITAAVNNASLDPSDLEKAYEMFHADMNNVVIHFGLVGCAFMFFGFIQFS 119
Query: 3312 IMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALII 3133
+ KY+GDNTTYR+R ++I RLLKKDA+YFD++STG+LSTVLNDNLERFRE FNEKIA II
Sbjct: 120 LFKYIGDNTTYRLRHKFILRLLKKDAKYFDTISTGYLSTVLNDNLERFREAFNEKIAFII 179
Query: 3132 AFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIA 2953
F TDF +GTALAFYT W LASYG F+ GI SG +NS +MK+ KQ+ HY+NAG+IA
Sbjct: 180 CFSTDFAIGTALAFYTSWTLASYGSVFAFGIVISGLLNSTSMMKSNEKQSMHYSNAGAIA 239
Query: 2952 FQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVL 2773
FQ L ++KTV SLNGQ E+E+Y+ ELK GEK+G RRA + SRG+++FFCN+LN +L
Sbjct: 240 FQALCSFKTVISLNGQTQELEKYSAELKEGEKFGSRRAFFLATSRGLSHFFCNALNGTIL 299
Query: 2772 YVGATMIYSGTLETAVVVR--------------------------------------DDN 2707
YVGA +IY+ T+ T +V DD+
Sbjct: 300 YVGADLIYNKTMNTVAIVTLFHYMLFSAFSLGEAFLHISYLLNAINSATPIFDVLTSDDD 359
Query: 2706 VIE--KDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGS 2533
+IE +D D + G +SF NVKF+YP+RPD +L+GISFDV+ GECIALVGASGS
Sbjct: 360 MIENNQDNEQTDSNKTIQGMLSFNNVKFAYPSRPDVDILRGISFDVKQGECIALVGASGS 419
Query: 2532 GKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFG 2353
GKST+VQLLLH+YNI SG I I L+D+N+K+LR IGVVSQEPVLFNTTIEENIRFG
Sbjct: 420 GKSTIVQLLLHFYNIQSGTIKIGDSHLHDINLKQLRNAIGVVSQEPVLFNTTIEENIRFG 479
Query: 2352 NPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKI 2173
NPN + EIY ALRKANAYDFVC+ G+KTIVGERG QLSGGQKQRIAIAR LV+NP I
Sbjct: 480 NPNATSSEIYEALRKANAYDFVCNIKDGLKTIVGERGAQLSGGQKQRIAIARVLVKNPAI 539
Query: 2172 LLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGN 1993
LLLDEATSALD+ SE+ VQ AL+ AS+GRTTI++AHRLSTIR+ KI+VM G+I EVG+
Sbjct: 540 LLLDEATSALDSASERAVQLALKKASEGRTTIIIAHRLSTIRHCDKIMVMSNGKIAEVGS 599
Query: 1992 HDELIAKRGVYNDLVQAQLLESHDDHEELPPLAARQLSQELSPLHSYAIQRSTSNDAGVH 1813
H+ELI+ Y++LV+AQ +S E++ A ++ Q+ P ND
Sbjct: 600 HEELISMDREYSNLVRAQFFDSQSVEEDINGQGAEEVIQKTPP---------NLNDG--- 647
Query: 1812 DDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTY 1633
+ +E +L E S + KSN+ E++++CRPD L +AV GSAIQG ++PIL+Q+IV+TY
Sbjct: 648 -EPLEELLKETSSDIEIKSNIWEVLRECRPDAFLLSMAVIGSAIQGCNFPILSQIIVQTY 706
Query: 1632 EGFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLS 1453
+ +AM GE++L Y H WA F+ L V RP+TLYCQ+++FGKVSE+LSTRLRIKSF H+LS
Sbjct: 707 KAYAMDGENILTYGHFWAAMFLVLGVIRPITLYCQFFFFGKVSEKLSTRLRIKSFQHLLS 766
Query: 1452 LPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMT 1273
LPCAFYDDP HS TRL NRLNTD SN+KAAVD RLG ++M++V+ S+AI A Y WK+T
Sbjct: 767 LPCAFYDDPKHSPTRLVNRLNTDPSNIKAAVDARLGSLLMSMVSFSLAILIACYYSWKLT 826
Query: 1272 LEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMS 1093
L+V++FFP +I+ED++AFENSN+ AIE L+N++TV+ALN+E ++++
Sbjct: 827 LQVVLFFPVLYYAKFLYKKTTTISIKEDSVAFENSNKIAIEVLDNMKTVKALNMEARVIN 886
Query: 1092 LISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVL 913
L+ E+L + SY +R+++ G ANG S C VY++SFKFGTYL L+KEV PMD YL L
Sbjct: 887 LVMEYLAVLKTSYPRRSVVMGLANGFSAGCSQIVYAISFKFGTYLILQKEVIPMDMYLSL 946
Query: 912 MTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGEN 733
+TLS T+NMAGSA +Y+PD++KA+H+AGLIF+LFTYPATMPF+S G ++I KGE+ GEN
Sbjct: 947 ITLSYTSNMAGSAISYMPDFRKAIHSAGLIFNLFTYPATMPFNSDTGSRSITKGEVNGEN 1006
Query: 732 VQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSE 553
V+FHY QRPD +L+ VNLKV+ GKTLA+VGPSG GKSTIISLLE FY A G +KID++
Sbjct: 1007 VKFHYHQRPDYTVLDSVNLKVEAGKTLAIVGPSGSGKSTIISLLEMFYRADQGFIKIDND 1066
Query: 552 NVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQ 373
NVE+INL+HLRSNL LVSQ P LFNCSIR+N+LYGLTR++ Q E+E ALQ ANAFNFVFQ
Sbjct: 1067 NVENINLDHLRSNLGLVSQGPVLFNCSIRDNILYGLTRNISQTEIENALQIANAFNFVFQ 1126
Query: 372 FPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDT 193
PQGLDT+VG+RGAQLSGGQKQRIAI RAILRNPK+LLLDEATSALD++SEK+VQNALDT
Sbjct: 1127 LPQGLDTIVGDRGAQLSGGQKQRIAITRAILRNPKLLLLDEATSALDTESEKIVQNALDT 1186
Query: 192 ASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
ASERLST+VVAHRLST++NADSIAVL+NGKV EQGTH +LL + YWRLVQ Q
Sbjct: 1187 ASERLSTIVVAHRLSTIINADSIAVLRNGKVVEQGTHNQLLAVKGDYWRLVQHQ 1240
>gi|7511495|pir||T18940 multidrug resistance protein homolog -
Caenorhabditis elegans
Length = 1238
Score = 1494 bits (3868), Expect = 0.0
Identities = 753/1254 (60%), Positives = 952/1254 (75%), Gaps = 40/1254 (3%)
Frame = -1
Query: 3672 ENSNNFSTPLLPQSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSY 3493
ENS N L+P +EKK + F++VV++C+S +EKFLF++GV+ ++ TG QPFMSY
Sbjct: 2 ENSEN--DVLIPVENEKKTTNWTKFVKVVWQCTSKWEKFLFVIGVVSAICTGLTQPFMSY 59
Query: 3492 TFGEVSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHA 3313
TFGEVSQ V IT A+NN ++DP+DLEKAYE + MN VV HF L GCA+ F +Q +
Sbjct: 60 TFGEVSQAFVRITAAVNNASLDPSDLEKAYEMFHADMNNVVIHFGLVGCAFMFFGFIQFS 119
Query: 3312 IMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALII 3133
+ KY+GDNTTYR+R ++I RLLKKDA+YFD++STG+LSTVLNDNLERFRE FNEKIA II
Sbjct: 120 LFKYIGDNTTYRLRHKFILRLLKKDAKYFDTISTGYLSTVLNDNLERFREAFNEKIAFII 179
Query: 3132 AFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIA 2953
F TDF +GTALAFYT W LASYG F+ GI SG +NS +MK+ KQ+ HY+NAG+IA
Sbjct: 180 CFSTDFAIGTALAFYTSWTLASYGSVFAFGIVISGLLNSTSMMKSNEKQSMHYSNAGAIA 239
Query: 2952 FQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVL 2773
FQ L ++KTV SLNGQ E+E+Y+ ELK GEK+G RRA + SRG+++FFCN+LN +L
Sbjct: 240 FQALCSFKTVISLNGQTQELEKYSAELKEGEKFGSRRAFFLATSRGLSHFFCNALNGTIL 299
Query: 2772 YVGATMIYSGTLETAVVVR--------------------------------------DDN 2707
YVGA +IY+ T+ T +V DD+
Sbjct: 300 YVGADLIYNKTMNTVAIVTLFHYMLFSAFSLGEAFLHISYLLNAINSATPIFDVLTSDDD 359
Query: 2706 VIE--KDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGS 2533
+IE +D D + G +SF NVKF+YP+RPD +L+GISFDV+ GECIALVGASGS
Sbjct: 360 MIENNQDNEQTDSNKTIQGMLSFNNVKFAYPSRPDVDILRGISFDVKQGECIALVGASGS 419
Query: 2532 GKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFG 2353
GKST+VQLLLH+YNI SG I I L+D+N+K+LR IGVVSQEPVLFNTTIEENIRFG
Sbjct: 420 GKSTIVQLLLHFYNIQSGTIKIGDSHLHDINLKQLRNAIGVVSQEPVLFNTTIEENIRFG 479
Query: 2352 NPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKI 2173
NPN + EIY ALRKANAYDFVC+ G+KTIVGERG QLSGGQKQRIAIAR LV+NP I
Sbjct: 480 NPNATSSEIYEALRKANAYDFVCNIKDGLKTIVGERGAQLSGGQKQRIAIARVLVKNPAI 539
Query: 2172 LLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGN 1993
LLLDEATSALD+ SE+ VQ AL+ AS+GRTTI++AHRLSTIR+ KI+VM G+I EVG+
Sbjct: 540 LLLDEATSALDSASERAVQLALKKASEGRTTIIIAHRLSTIRHCDKIMVMSNGKIAEVGS 599
Query: 1992 HDELIAKRGVYNDLVQAQLLESHDDHEELPPLAARQLSQELSPLHSYAIQRSTSNDAGVH 1813
H+ELI+ Y++LV+AQ +S E++ A ++ Q+ P ND
Sbjct: 600 HEELISMDREYSNLVRAQFFDSQSVEEDINGQGAEEVIQKTPP---------NLNDG--- 647
Query: 1812 DDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTY 1633
+ +E +L E S + KSN+ E++++CRPD L +AV GSAIQG ++PIL+Q+IV+TY
Sbjct: 648 -EPLEELLKETSSDIEIKSNIWEVLRECRPDAFLLSMAVIGSAIQGCNFPILSQIIVQTY 706
Query: 1632 EGFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLS 1453
+ +AM GE++L Y H WA F+ L V RP+TLYCQ+++FGKVSE+LSTRLRIKSF H+LS
Sbjct: 707 KAYAMDGENILTYGHFWAAMFLVLGVIRPITLYCQFFFFGKVSEKLSTRLRIKSFQHLLS 766
Query: 1452 LPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMT 1273
LPCAFYDDP HS TRL NRLNTD SN+KAAVD RLG ++M++V+ S+AI A Y WK+T
Sbjct: 767 LPCAFYDDPKHSPTRLVNRLNTDPSNIKAAVDARLGSLLMSMVSFSLAILIACYYSWKLT 826
Query: 1272 LEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMS 1093
L+ ++++ +I+ED++AFENSN+ AIE L+N++TV+ALN+E ++++
Sbjct: 827 LQAILYY-----AKFLYKKTTTISIKEDSVAFENSNKIAIEVLDNMKTVKALNMEARVIN 881
Query: 1092 LISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVL 913
L+ E+L + SY +R+++ G ANG S C VY++SFKFGTYL L+KEV PMD YL L
Sbjct: 882 LVMEYLAVLKTSYPRRSVVMGLANGFSAGCSQIVYAISFKFGTYLILQKEVIPMDMYLSL 941
Query: 912 MTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGEN 733
+TLS T+NMAGSA +Y+PD++KA+H+AGLIF+LFTYPATMPF+S G ++I KGE+ GEN
Sbjct: 942 ITLSYTSNMAGSAISYMPDFRKAIHSAGLIFNLFTYPATMPFNSDTGSRSITKGEVNGEN 1001
Query: 732 VQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSE 553
V+FHY QRPD +L+ VNLKV+ GKTLA+VGPSG GKSTIISLLE FY A G +KID++
Sbjct: 1002 VKFHYHQRPDYTVLDSVNLKVEAGKTLAIVGPSGSGKSTIISLLEMFYRADQGFIKIDND 1061
Query: 552 NVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQ 373
NVE+INL+HLRSNL LVSQ P LFNCSIR+N+LYGLTR++ Q E+E ALQ ANAFNFVFQ
Sbjct: 1062 NVENINLDHLRSNLGLVSQGPVLFNCSIRDNILYGLTRNISQTEIENALQIANAFNFVFQ 1121
Query: 372 FPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDT 193
PQGLDT+VG+RGAQLSGGQKQRIAI RAILRNPK+LLLDEATSALD++SEK+VQNALDT
Sbjct: 1122 LPQGLDTIVGDRGAQLSGGQKQRIAITRAILRNPKLLLLDEATSALDTESEKIVQNALDT 1181
Query: 192 ASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
ASERLST+VVAHRLST++NADSIAVL+NGKV EQGTH +LL + YWRLVQ Q
Sbjct: 1182 ASERLSTIVVAHRLSTIINADSIAVLRNGKVVEQGTHNQLLAVKGDYWRLVQHQ 1235
>gi|39594943|emb|CAE70811.1| Hypothetical protein CBG17574
[Caenorhabditis briggsae]
Length = 1628
Score = 1110 bits (2871), Expect = 0.0
Identities = 571/1014 (56%), Positives = 738/1014 (72%), Gaps = 39/1014 (3%)
Frame = -1
Query: 3009 VMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMY 2830
+M + Q+ HYANAG IA+Q L +KTV SLNGQ E++ Y+ ELK GEK+GI RAL++
Sbjct: 1 MMGASKAQSYHYANAGGIAYQALSCFKTVISLNGQSYELKSYSSELKLGEKHGIHRALLF 60
Query: 2829 SISRGVTYFFCNSLNTVVLYVGATMIYSGTLETAVVV----------------------- 2719
+ SR VT FFC++LN +LY+GA +IY+ T++ A +V
Sbjct: 61 ATSRAVTNFFCSALNGTLLYIGAGLIYNKTMDQASIVTLFHYMMLSAYSLAEVLPHISNL 120
Query: 2718 ----------------RDDNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGI 2587
DDN+ +D D + +NG I FK+V+FSYPTRP+A+VLKGI
Sbjct: 121 LNAISSASSIFEILTSNDDNIENEDVPDD--QKPINGVIQFKDVRFSYPTRPNAKVLKGI 178
Query: 2586 SFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVV 2407
S +V+ GEC+ALVGASGSGKST+VQLLL +YN DSG+I IDG++L ++++K+LRR IGVV
Sbjct: 179 SLEVKRGECVALVGASGSGKSTLVQLLLRHYNKDSGSISIDGVELENISLKKLRRNIGVV 238
Query: 2406 SQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSG 2227
SQEP+LF+TTIE+NIRFGNP S EI+ AL+KANAY+FV SFP GI+TIVGE G QLSG
Sbjct: 239 SQEPILFDTTIEQNIRFGNPECSKFEIFDALKKANAYEFVASFPNGIETIVGEGGAQLSG 298
Query: 2226 GQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIR 2047
GQKQRIAIAR LV+NPKILLLDEATSALDNESE+ +QKAL AS+GRTTI++AHRLSTI
Sbjct: 299 GQKQRIAIARVLVKNPKILLLDEATSALDNESEREIQKALRKASEGRTTIIIAHRLSTIN 358
Query: 2046 NASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLESHDDHEELPPLAARQLSQELS 1867
N KIIVM +G+I+E G H LI K G YN+L+ +Q+ +S + +Q SQ+
Sbjct: 359 NCDKIIVMSQGQIIESGAHKHLIQKAGAYNNLINSQIFDSEE----------KQTSQK-D 407
Query: 1866 PLHSYAIQRSTSNDAGVHDDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGS 1687
PL I+ + SN + L + +E S EI+ +CRP Y +L A+ GS
Sbjct: 408 PLDINKIKEN-SNSLRKSSKGSQASLTDTPEEKEVSSGFWEIINECRPQYFWLLTAIIGS 466
Query: 1686 AIQGVSYPILAQLIVRTYEGFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKV 1507
+QG+S P+LAQLIVRTY+ ++M GED+L Y H WA F L + RP+T Y +Y +G+V
Sbjct: 467 FMQGLSPPLLAQLIVRTYKAYSMEGEDILIYGHFWASMFFALGLIRPITAYTTHYCYGRV 526
Query: 1506 SEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTV 1327
+E+LSTRLRIKSF HMLSLPCAFYD+ +S TRL+NRLNTD+SNVK AVD RLG + T+
Sbjct: 527 AEKLSTRLRIKSFHHMLSLPCAFYDESKNSPTRLANRLNTDASNVKGAVDSRLGTIFTTL 586
Query: 1326 VAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEA 1147
V+ ++I+ AS Y WK+T+++++FFP ++++D+ E SN+ A+E
Sbjct: 587 VSFLVSISVASYYSWKLTIQIILFFPILYFGKRCYDNATVQSVKQDSALIEKSNKIAVEV 646
Query: 1146 LENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFG 967
L N++TVR+LN+ DK+MS+I L+ + K Y +AI G ANG S+ C F Y+ SFKFG
Sbjct: 647 LNNIKTVRSLNMGDKVMSMIIGELEVLRKKYRWKAITLGLANGFSVICHYFFYAASFKFG 706
Query: 966 TYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPF 787
T+L L++E+ PM+ Y+ +TLS T+NM G+ YLP+Y+KAVHAAGLIF+L PATMP+
Sbjct: 707 THLILQREILPMNMYVSFITLSYTSNMVGNVMLYLPEYRKAVHAAGLIFNLLKTPATMPY 766
Query: 786 SSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIIS 607
S +G I+ G + G N+ FHY QR D M+L VNL + PGKTLALVGPSG GKS+ IS
Sbjct: 767 DSKEGSMEIKNGVVKGSNISFHYHQRLDHMVLKNVNLSLKPGKTLALVGPSGSGKSSFIS 826
Query: 606 LLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQ 427
L+ERFY G VKID+E+VEDIN++HLRSNL LV+QEP LFNCSIR+NLLYGL V +
Sbjct: 827 LIERFYQVDTGCVKIDNEDVEDINIHHLRSNLGLVAQEPVLFNCSIRQNLLYGLEELVEE 886
Query: 426 LELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEA 247
+++EKAL+TANA +F+ +FP+GL+T+VGE GAQLSGGQKQRIAIARAILRNPK+LLLDEA
Sbjct: 887 IKIEKALRTANALDFIQKFPEGLNTIVGEHGAQLSGGQKQRIAIARAILRNPKILLLDEA 946
Query: 246 TSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGT 85
TSALDSDSEK+VQNALDTA ERLSTVVVAHRLST+VNADSIAV +NG+V EQG+
Sbjct: 947 TSALDSDSEKLVQNALDTAIERLSTVVVAHRLSTIVNADSIAVFENGQVVEQGS 1000
Score = 721 bits (1861), Expect = 0.0
Identities = 368/580 (63%), Positives = 452/580 (77%), Gaps = 5/580 (0%)
Frame = -1
Query: 2370 ENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTL 2191
ENI FGNPN ++ EIY ALRKANAYDFV SFPKGIK++VGERG QLSGGQKQRIAIARTL
Sbjct: 1049 ENILFGNPNATVSEIYEALRKANAYDFVNSFPKGIKSVVGERGAQLSGGQKQRIAIARTL 1108
Query: 2190 VRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGE 2011
VRNPKILLL EATSALDNESE VVQ+ALE AS+GRTTIV+AHRLSTIRNASKIIVM KGE
Sbjct: 1109 VRNPKILLL-EATSALDNESEHVVQRALEKASEGRTTIVIAHRLSTIRNASKIIVMDKGE 1167
Query: 2010 IVEVGNHDELIAKRGVYNDLVQAQLLESHDDHEELPPLAARQLSQELSPLHSYAIQRSTS 1831
IV+VGN + H E L+ARQ S + S +
Sbjct: 1168 IVKVGN-------------------VLDHSSQE----LSARQDSSRT--------EFSET 1196
Query: 1830 NDAGVHDDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQ 1651
N+A DD+++R+++EL++EGA+KSNLREI+K C+PDYC A+ GSA+QG+SY I +
Sbjct: 1197 NEA--QDDEIKRLMNELTEEGAQKSNLREIIKMCKPDYCLFLTALAGSALQGLSYQISVK 1254
Query: 1650 LIVRTYEGFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKS 1471
L VR YE FAM GED++ Y H WA + + LA+FRP+TL CQYYY GKVSE+LSTRLR+KS
Sbjct: 1255 LTVRAYEAFAMNGEDIMIYGHFWAFAILLLALFRPITLRCQYYYLGKVSERLSTRLRMKS 1314
Query: 1470 FSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASL 1291
F H++SLPC+FYDDP HSA RLSNRLNTD+SNVKA+VDDRLG V MT VAISIAI+T+++
Sbjct: 1315 FKHLMSLPCSFYDDPKHSAIRLSNRLNTDASNVKASVDDRLGSVFMTFVAISIAISTSTV 1374
Query: 1290 YCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNL 1111
Y WKMT++VL+ P AI++DT+AFENSNR AIEA+E++RTVRALN+
Sbjct: 1375 YSWKMTIQVLLLCPILYLAEYCYERAIDGAIEKDTLAFENSNRAAIEAIEHIRTVRALNM 1434
Query: 1110 EDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPM 931
ED+IM ++++HLQK H S FKRA+IQGAANG CF ++YS+SFKFGT+LA+ KE+ PM
Sbjct: 1435 EDRIMDMVADHLQKSHNSCFKRAVIQGAANGFFCCCFFYIYSISFKFGTWLAMHKEIMPM 1494
Query: 930 DTYLVLMTLSMTAN-----MAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKK 766
+TY+V MTL++T+ MAGSA AYLPDYKKA HAAGLIFHLFTYP TM + S DG K
Sbjct: 1495 ETYMVSMTLTLTSTYDLWLMAGSAVAYLPDYKKAAHAAGLIFHLFTYPETMAYGSKDGTK 1554
Query: 765 NIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLAL 646
NI+ G+++GEN++FHY+QRPD+ IL+GVNL+V+PGKTLAL
Sbjct: 1555 NIKLGKVVGENLKFHYEQRPDKTILDGVNLRVEPGKTLAL 1594
Score = 255 bits (651), Expect = 6e-66
Identities = 189/602 (31%), Positives = 294/602 (48%), Gaps = 40/602 (6%)
Frame = -1
Query: 3678 MEENSNNFSTPLLPQSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFM 3499
+ ++S L +EK+ S F ++ +C + F L ++ S M G P +
Sbjct: 421 LRKSSKGSQASLTDTPEEKEVSS--GFWEIINECRPQY--FWLLTAIIGSFMQGLSPPLL 476
Query: 3498 SYTFGEVSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQ 3319
+ Q++V A + + D Y + M FF G I A
Sbjct: 477 A-------QLIVRTYKAYSMEGEDIL----IYGHFWASM------FFALGLIRPITAYTT 519
Query: 3318 HAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSV--STGHLSTVLNDNLERFREVFNEKI 3145
H V + + R+R + +L ++D S L+ LN + + + ++
Sbjct: 520 HYCYGRVAEKLSTRLRIKSFHHMLSLPCAFYDESKNSPTRLANRLNTDASNVKGAVDSRL 579
Query: 3144 ALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANA 2965
I + F + ++A Y W+L I F + F +++ + + +
Sbjct: 580 GTIFTTLVSFLVSISVASYYSWKLTIQIILFFPILYFGKRCYDNATVQSVKQDSALIEKS 639
Query: 2964 GSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVT----YFFC 2797
IA + L KTV SLN + EL+ K +A+ ++ G + YFF
Sbjct: 640 NKIAVEVLNNIKTVRSLNMGDKVMSMIIGELEVLRKKYRWKAITLGLANGFSVICHYFFY 699
Query: 2796 NS----------------LNTVVLY---------VGATMIYSGTLETAV--------VVR 2716
+ +N V + VG M+Y AV +++
Sbjct: 700 AASFKFGTHLILQREILPMNMYVSFITLSYTSNMVGNVMLYLPEYRKAVHAAGLIFNLLK 759
Query: 2715 DDNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASG 2536
+ D + +E++ NG + N+ F Y R D VLK ++ ++ G+ +ALVG SG
Sbjct: 760 TPATMPYDSKEGSMEIK-NGVVKGSNISFHYHQRLDHMVLKNVNLSLKPGKTLALVGPSG 818
Query: 2535 SGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRF 2356
SGKS+ + L+ +Y +D+G + ID D+ D+NI LR +G+V+QEPVLFN +I +N+ +
Sbjct: 819 SGKSSFISLIERFYQVDTGCVKIDNEDVEDINIHHLRSNLGLVAQEPVLFNCSIRQNLLY 878
Query: 2355 G-NPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNP 2179
G V +I ALR ANA DF+ FP+G+ TIVGE G QLSGGQKQRIAIAR ++RNP
Sbjct: 879 GLEELVEEIKIEKALRTANALDFIQKFPEGLNTIVGEHGAQLSGGQKQRIAIARAILRNP 938
Query: 2178 KILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEV 1999
KILLLDEATSALD++SE++VQ AL+ A + +T+VVAHRLSTI NA I V + G++VE
Sbjct: 939 KILLLDEATSALDSDSEKLVQNALDTAIERLSTVVVAHRLSTIVNADSIAVFENGQVVEQ 998
Query: 1998 GN 1993
G+
Sbjct: 999 GS 1000
Score = 246 bits (629), Expect = 2e-63
Identities = 143/391 (36%), Positives = 222/391 (56%), Gaps = 8/391 (2%)
Frame = -1
Query: 1179 FENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCF 1000
+ N+ A +AL +TV +LN + + S L+ K RA++ + ++
Sbjct: 12 YANAGGIAYQALSCFKTVISLNGQSYELKSYSSELKLGEKHGIHRALLFATSRAVTNFFC 71
Query: 999 LFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIF 820
+ G L K + + + ++A ++ + A+ +A IF
Sbjct: 72 SALNGTLLYIGAGLIYNKTMDQASIVTLFHYMMLSAYSLAEVLPHISNLLNAISSASSIF 131
Query: 819 HLFTYPATMPFSSSDGKKNIE--------KGEIIGENVQFHYDQRPDRMILNGVNLKVDP 664
+ T S+ D +N + G I ++V+F Y RP+ +L G++L+V
Sbjct: 132 EILT-------SNDDNIENEDVPDDQKPINGVIQFKDVRFSYPTRPNAKVLKGISLEVKR 184
Query: 663 GKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTL 484
G+ +ALVG SG GKST++ LL R Y+ G + ID +E+I+L LR N+ +VSQEP L
Sbjct: 185 GECVALVGASGSGKSTLVQLLLRHYNKDSGSISIDGVELENISLKKLRRNIGVVSQEPIL 244
Query: 483 FNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQR 304
F+ +I +N+ +G + E+ AL+ ANA+ FV FP G++T+VGE GAQLSGGQKQR
Sbjct: 245 FDTTIEQNIRFG-NPECSKFEIFDALKKANAYEFVASFPNGIETIVGEGGAQLSGGQKQR 303
Query: 303 IAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSI 124
IAIAR +++NPK+LLLDEATSALD++SE+ +Q AL ASE +T+++AHRLST+ N D I
Sbjct: 304 IAIARVLVKNPKILLLDEATSALDNESEREIQKALRKASEGRTTIIIAHRLSTINNCDKI 363
Query: 123 AVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
V+ G++ E G H+ L++K Y L+ Q
Sbjct: 364 IVMSQGQIIESGAHKHLIQKAGAYNNLINSQ 394
Score = 139 bits (349), Expect = 7e-31
Identities = 73/126 (57%), Positives = 99/126 (77%)
Frame = -1
Query: 465 ENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARA 286
EN+L+G + E+ +AL+ ANA++FV FP+G+ ++VGERGAQLSGGQKQRIAIAR
Sbjct: 1049 ENILFGNPNATVS-EIYEALRKANAYDFVNSFPKGIKSVVGERGAQLSGGQKQRIAIART 1107
Query: 285 ILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNG 106
++RNPK+LLL EATSALD++SE VVQ AL+ ASE +T+V+AHRLST+ NA I V+ G
Sbjct: 1108 LVRNPKILLL-EATSALDNESEHVVQRALEKASEGRTTIVIAHRLSTIRNASKIIVMDKG 1166
Query: 105 KVAEQG 88
++ + G
Sbjct: 1167 EIVKVG 1172
Score = 80.5 bits (197), Expect = 3e-13
Identities = 40/70 (57%), Positives = 47/70 (67%)
Frame = -1
Query: 2988 QNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVT 2809
+N GSIAFQ LGA+KTVCSL GQ+ E+ RY+EELKAGE+YG R+A S SRG
Sbjct: 991 ENGQVVEQGSIAFQALGAFKTVCSLTGQQQEVHRYSEELKAGERYGFRKAFYNSASRGEN 1050
Query: 2808 YFFCNSLNTV 2779
F N TV
Sbjct: 1051 ILFGNPNATV 1060
>gi|39585393|emb|CAE61715.1| Hypothetical protein CBG05664
[Caenorhabditis briggsae]
Length = 1294
Score = 895 bits (2313), Expect = 0.0
Identities = 505/1238 (40%), Positives = 729/1238 (58%), Gaps = 50/1238 (4%)
Frame = -1
Query: 3588 VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEK 3409
+F+ +S ++ + ++G+L S TG P MS G VSQ V I + N T DPA ++K
Sbjct: 35 LFRYTSTMDRIMLIVGILVSCATGLGLPLMSIIMGNVSQNFVEIGTILMNST-DPAVIKK 93
Query: 3408 AYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQY 3229
A +++ + Q + G F +Q + + +N + R R+++ +++ + +
Sbjct: 94 AKDDFSHDVIQNCLQYVYLGAGIFAAGMIQASCFLIICENLSNRFRREFFYSVMRHEIAW 153
Query: 3228 FDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFS 3049
+D ++G LS L DNLER RE +K+ L + F G A+AF DW L + S
Sbjct: 154 YDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFLGGFAVAFSYDWLLTLIMMSLS 213
Query: 3048 LGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELK 2869
+ G + + K+ YA AG IA + L + +TV + NGQ+ E +RY E L
Sbjct: 214 PFMMICGLFLAKLLATAATKEAKQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEEALS 273
Query: 2868 AGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYSGTLETAVVVRD-------- 2713
G K GI+++ + + + + +VG +Y+G L++ V+
Sbjct: 274 HGRKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYNGRLDSGTVLTVFFSVMMGS 333
Query: 2712 ---------------------------DNVIEKD--ETDYDVEVEVNGNISFKNVKFSYP 2620
D E D T +++G I +N++F+YP
Sbjct: 334 MALGQAGQQFATIGTALGAAASLYEVIDRTPEIDAYSTKGVTPEKISGRIKIQNIEFTYP 393
Query: 2619 TRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMN 2440
TRPD Q+LK +S + Q G+ IALVG+SG GKST++QLL +YN D+G I+ID + + D N
Sbjct: 394 TRPDVQILKDVSLEAQPGQTIALVGSSGCGKSTIIQLLQRFYNPDAGKIYIDDIAIEDFN 453
Query: 2439 IKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKT 2260
IK LR+++GVVSQEP LFNT+IE+NIR+G +V I AL++ANA DF+ +FP+G+ T
Sbjct: 454 IKYLRQLVGVVSQEPNLFNTSIEQNIRYGRADVDSDAINRALKEANALDFIKTFPEGLNT 513
Query: 2259 IVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTT 2080
+VG+RG Q+SGGQKQRIAIAR LVRNPKILLLDEATSALD ESE VVQ AL+NAS+GRTT
Sbjct: 514 LVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESVVQAALDNASRGRTT 573
Query: 2079 IVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLESHDDHEELPP 1900
IV+AHRLST+RNA KIIVM+ G+++E+G HD LI ++G+Y++LV AQ+ D+
Sbjct: 574 IVIAHRLSTVRNADKIIVMKAGKVMEIGTHDTLIEQKGLYHELVHAQVFADVDEKPRAKK 633
Query: 1899 LAARQLSQELSPLHSYAI--QRSTSNDAG-------VHDDDMERILDELSKEGAKKSNLR 1747
A R+LS++ S I Q S + + + +++R+ EL +EGA K+NL
Sbjct: 634 EAERRLSRQTSARKGSLIKTQESQAEEKSGPPPAPEPAEKEIKRLRKELEEEGAVKANLF 693
Query: 1746 EIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIG-EDMLYYSHLWALSF 1570
+I+K RP++ ++F A+ + IQG P + + F+ E M H WAL F
Sbjct: 694 KILKYARPEWMYIFFAIIAALIQGAVMPAFSLFFSQIINVFSNPDREQMKKDGHFWALMF 753
Query: 1569 MFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLN 1390
+ LA + ++ Q +FG +E L+ R+R K + ++L ++D P HS R++ RL
Sbjct: 754 LVLAAIQGTSMLFQCAFFGVAAEGLTMRVRSKVYRNVLRQDATYFDMPKHSPGRITTRLA 813
Query: 1389 TDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXX 1210
TD+ N+K+A+D RLG V + ++ + A Y W+M L V+ FP
Sbjct: 814 TDAPNIKSAIDYRLGSVFNAIASVGGGLGIAFYYGWQMALLVMAIFPFMAVGQALVIKYH 873
Query: 1209 XXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQG 1030
+ D ENS +TA+EA+EN+RTV+AL L+ K+ ++ HL H +AII+G
Sbjct: 874 GGSATADAKEMENSGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDSPHSGNVSKAIIRG 933
Query: 1029 AANGLSLSCFLFVYSVSFKFGTYLALRKEV--APMDTYLVLMTLSMTANMAGSAAAYLPD 856
G + S F Y+ +F+FG +L + V +P VL +S + G AA+Y P+
Sbjct: 934 LTYGFANSIQFFTYAAAFRFGLFLIFNQNVLMSPEHVLKVLFAISFSFGTIGFAASYFPE 993
Query: 855 YKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNL 676
Y KA AAGLIF++ + ++ G GE+ V F Y +RP IL G+++
Sbjct: 994 YIKATFAAGLIFNMLEEEPRIDGMTNAGTLPALSGEVKLNKVFFRYPERPAVPILQGLDV 1053
Query: 675 KVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQ 496
V PG+TLALVGPSGCGKST+ISLLER Y ++G V ID+ N+ +N HLR ++ALVSQ
Sbjct: 1054 HVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTIDNNNLRQMNPKHLRKHIALVSQ 1113
Query: 495 EPTLFNCSIRENLLYGL-TRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSG 319
EP LF+ SIREN++YGL + + A + AN F+ + P G T VGE+G QLSG
Sbjct: 1114 EPILFDTSIRENIIYGLQPGEYTEEAIAVACEKANIHKFISELPDGYQTRVGEKGTQLSG 1173
Query: 318 GQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVV 139
GQKQRIAIARA++RNPK+LLLDEATSALD++SEK VQ ALD A++ + +VVAHRLST+V
Sbjct: 1174 GQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQIALDAAAKDRTCIVVAHRLSTIV 1233
Query: 138 NADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGI 25
NA I V+KNGKV EQGTH EL+ KR Y+ L QKQ I
Sbjct: 1234 NAGCIMVVKNGKVVEQGTHLELMAKRGAYFALTQKQSI 1271
>gi|17558664|ref|NP_507487.1| P-GlycoProtein related (pgp-9)
[Caenorhabditis elegans]
gi|7497530|pir||T19982 hypothetical protein C47A10.1 - Caenorhabditis
elegans
gi|3875004|emb|CAB03973.1| Hypothetical protein C47A10.1
[Caenorhabditis elegans]
gi|3879215|emb|CAB07855.1| Hypothetical protein C47A10.1
[Caenorhabditis elegans]
Length = 1294
Score = 887 bits (2292), Expect = 0.0
Identities = 504/1256 (40%), Positives = 732/1256 (58%), Gaps = 55/1256 (4%)
Frame = -1
Query: 3633 SDEKK-----PSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQV 3469
S EKK P +I F +++ +S ++ + +G++ S TG P MS G VSQ
Sbjct: 16 SSEKKEEAPPPPKISIF--QLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQN 73
Query: 3468 LVTITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDN 3289
VT+ + ++ A E+ + Q + GC F LQ + + +
Sbjct: 74 FVTLGTIFLDPNSTASEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEK 133
Query: 3288 TTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTL 3109
+ R R+Q+ +++++ ++D ++G LS L DNLER RE +K+ L + F
Sbjct: 134 LSNRFRRQFFHSVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIG 193
Query: 3108 GTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYK 2929
G A+AF DW L + S + G + + K+ YA AG IA + L + +
Sbjct: 194 GFAVAFTYDWLLTLIMMSLSPFMMICGLFLAKLLATAATKEAKQYAVAGGIAEEVLTSIR 253
Query: 2928 TVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIY 2749
TV + NGQ+ E +RY + L+ G+K GI+++ + + + + +VG +Y
Sbjct: 254 TVIAFNGQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVY 313
Query: 2748 SGTLETAVVVRD-----------------------------------DNVIEKD--ETDY 2680
SG LE+ V+ D + E D T+
Sbjct: 314 SGRLESGTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEG 373
Query: 2679 DVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLH 2500
+++G IS V+F+YPTR D ++LKG+S D Q G+ +ALVG+SG GKST++QLL
Sbjct: 374 QTPSKISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQR 433
Query: 2499 YYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYG 2320
+YN D+G I ID + + D NIK LR+++GVVSQEP LFNT+IE+NIR+G +VS +I
Sbjct: 434 FYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIAR 493
Query: 2319 ALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALD 2140
AL++ANA DF+ +FP+G+ T+VG+RG Q+SGGQKQRIAIAR LVRNPKILLLDEATSALD
Sbjct: 494 ALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALD 553
Query: 2139 NESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVY 1960
ESE +VQ ALENAS+GRTTIV+AHRLST+RNA KIIVM+ G+++EVG H+ LI ++G+Y
Sbjct: 554 AESESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLY 613
Query: 1959 NDLVQAQLLESHDD---HEELPPLAARQLSQELSPLHSYAIQRSTSNDAG------VHDD 1807
++LV AQ+ DD +E +RQ SQ ++ + G +
Sbjct: 614 HELVHAQVFADVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDEKPGAPPAPEAAEK 673
Query: 1806 DMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEG 1627
+++R+ EL +EGA K+NL +I++ RP++ ++F A+ + IQG P + +
Sbjct: 674 EIKRLKKELEEEGAVKANLFKILRYARPEWIYIFFAIIAALIQGAVMPAFSLFFSQIINV 733
Query: 1626 FAMIGED-MLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSL 1450
F+ D M H WAL F+ LA + ++ Q FG +E+L+ R+R K + ++L
Sbjct: 734 FSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQ 793
Query: 1449 PCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTL 1270
++D P HS R++ RL TD+ N+K+A+D RLG + + ++ + A Y W+M
Sbjct: 794 DATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAF 853
Query: 1269 EVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSL 1090
V+ FP + D EN+ +TA+EA+EN+RTV+AL L+ K+ ++
Sbjct: 854 LVMAIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNI 913
Query: 1089 ISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEV--APMDTYLV 916
HL H +AII+G G + S F Y+ +F+FG +L K V P + V
Sbjct: 914 FCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRV 973
Query: 915 LMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGE 736
L +S + G AA+Y P+Y KA AAGLIF++ + +S G GE+
Sbjct: 974 LFAISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLN 1033
Query: 735 NVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDS 556
V F Y +RP IL G+N+ V PG+TLALVGPSGCGKST+ISLLER Y ++G V +D+
Sbjct: 1034 KVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDN 1093
Query: 555 ENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGL-TRSVPQLELEKALQTANAFNFV 379
++ +N HLR ++ALVSQEP LF+ SIREN++YGL ++E A AN F+
Sbjct: 1094 NDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFI 1153
Query: 378 FQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNAL 199
+ P G +T VGE+G QLSGGQKQRIAIARA++RNPK+LLLDEATSALD++SEK VQ AL
Sbjct: 1154 DELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVAL 1213
Query: 198 DTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
D A++ + +VVAHRLST+VNA I V+KNG+V EQGTH EL+ KR Y+ L QKQ
Sbjct: 1214 DAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQ 1269
>gi|17541710|ref|NP_502413.1| P-GlycoProtein related (pgp-1)
[Caenorhabditis elegans]
gi|29429182|sp|P34712|MDR1_CAEEL Multidrug resistance protein 1
(P-glycoprotein A)
gi|7505559|pir||T23476 hypothetical protein K08E7.9 - Caenorhabditis
elegans
gi|3878418|emb|CAB01232.1| Hypothetical protein K08E7.9
[Caenorhabditis elegans]
Length = 1321
Score = 832 bits (2149), Expect = 0.0
Identities = 477/1253 (38%), Positives = 716/1253 (57%), Gaps = 67/1253 (5%)
Frame = -1
Query: 3588 VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNK--TIDPADL 3415
+++ ++ EK L +G L +++TG P MS G+VSQ + INN T P
Sbjct: 65 LYRYTTTLEKLLLFIGTLVAVITGAGLPLMSILQGKVSQAFINEQIVINNNGSTFLPTGQ 124
Query: 3414 EKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDA 3235
++E + VV+ + + + YV + R+R++++ +L+++
Sbjct: 125 NYTKTDFEHDVMNVVWSYAAMTVGMWAAGQITVTCYLYVAEQMNNRLRREFVKSILRQEI 184
Query: 3234 QYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIF 3055
+FD+ +G L+T L DNLER +E +KI + +++ F G +AF W+L +
Sbjct: 185 SWFDTNHSGTLATKLFDNLERVKEGTGDKIGMAFQYLSQFITGFIVAFTHSWQLTLVMLA 244
Query: 3054 FSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEE 2875
+ A GF + + ++ YA AG + +T+ + +TV SLNG + E+ERY+
Sbjct: 245 VTPIQALCGFAIAKSMSTFAIRETLRYAKAGKVVEETISSIRTVVSLNGLRYELERYSTA 304
Query: 2874 LKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYSGTL-------------- 2737
++ +K G+ + L IS G + Y+G ++ G+L
Sbjct: 305 VEEAKKAGVLKGLFLGISFGAMQASNFISFALAFYIGVGWVHDGSLNFGDMLTTFSSVMM 364
Query: 2736 ----------ETAV-------------VVRDDNVIEKDETDYDVEVEVNGNISFKNVKFS 2626
+ AV V+ VI+ ++++ G+I+ +NV F+
Sbjct: 365 GSMALGLAGPQLAVLGTAQGAASGIYEVLDRKPVIDSSSKAGRKDMKIKGDITVENVHFT 424
Query: 2625 YPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLND 2446
YP+RPD +L+G++ V G+ +ALVG+SG GKST++ LLL YY++ G I IDG+D+ D
Sbjct: 425 YPSRPDVPILRGMNLRVNAGQTVALVGSSGCGKSTIISLLLRYYDVLKGKITIDGVDVRD 484
Query: 2445 MNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGI 2266
+N++ LR+ + VVSQEP LFN TIEENI G ++ E+ A + ANA F+ + P G
Sbjct: 485 INLEFLRKNVAVVSQEPALFNCTIEENISLGKEGITREEMVAACKMANAEKFIKTLPNGY 544
Query: 2265 KTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGR 2086
T+VG+RGTQLSGGQKQRIAIAR LVRNPKILLLDEATSALD ESE +VQ+AL+ A++GR
Sbjct: 545 NTLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAESEGIVQQALDKAAKGR 604
Query: 2085 TTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQ----------- 1939
TTI++AHRLSTIRNA II + G++VEVG+H L+A++G+Y DLV AQ
Sbjct: 605 TTIIIAHRLSTIRNADLIISCKNGQVVEVGDHRALMAQQGLYYDLVTAQTFTDAVDSAAE 664
Query: 1938 --------LLESHDDHEELPPLAARQLSQELSPLHSYAIQRSTS------NDAGVHDDDM 1801
+ +HE L A+ ++ ++ + S I T+ + + D +
Sbjct: 665 GKFSRENSVARQTSEHEGLSRQAS-EMDDIMNRVRSSTIGSITNGPVIDEKEERIGKDAL 723
Query: 1800 ERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFA 1621
R+ EL + A+K+NL EI+ RP LFI + + I G YP + FA
Sbjct: 724 SRLKQELEENNAQKTNLFEILYHARPHALSLFIGMSTATIGGFIYPTYSVFFTSFMNVFA 783
Query: 1620 MIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCA 1441
D L H WAL F+ LA + + + ++ G SE L+ LR K F ++LS
Sbjct: 784 GNPADFLSQGHFWALMFLVLAAAQGICSFLMTFFMGIASESLTRDLRNKLFRNVLSQHIG 843
Query: 1440 FYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVL 1261
F+D P +++ ++S RL TD N++ A+D R VI T+V++ I A Y W+M L ++
Sbjct: 844 FFDSPQNASGKISTRLATDVPNLRTAIDFRFSTVITTLVSMVAGIGLAFFYGWQMALLII 903
Query: 1260 MFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISE 1081
P + F +S + AIEA+ENVRTV+AL ED E
Sbjct: 904 AILPIVAFGQYLRGRRFTGKNVKSASEFADSGKIAIEAIENVRTVQALAREDTFYENFCE 963
Query: 1080 HLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALR--KEVAPMDTYLVLMT 907
L HK K A IQG + G + S + + +++ G L + + PM V+
Sbjct: 964 KLDIPHKEAIKEAFIQGLSYGCASSVLYLLNTCAYRMGLALIITDPPTMQPMRVLRVMYA 1023
Query: 906 LSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGENVQ 727
++++ + G A +Y P+Y KA A G+IF + + + S G+K G++I +NV+
Sbjct: 1024 ITISTSTLGFATSYFPEYAKATFAGGIIFGMLRKISKIDSLSLAGEKKKLYGKVIFKNVR 1083
Query: 726 FHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENV 547
F Y +RP+ IL G++ V+PG+TLALVGPSGCGKST+++LLERFY + GE+ ID +
Sbjct: 1084 FAYPERPEIEILKGLSFSVEPGQTLALVGPSGCGKSTVVALLERFYDTLGGEIFIDGSEI 1143
Query: 546 EDINLNHLRSNLALVSQEPTLFNCSIRENLLYGL-TRSVPQLELEKALQTANAFNFVFQF 370
+ +N H RS +A+VSQEPTLF+CSI EN++YGL SV ++E+A + AN NF+ +
Sbjct: 1144 KTLNPEHTRSQIAIVSQEPTLFDCSIAENIIYGLDPSSVTMAQVEEAARLANIHNFIAEL 1203
Query: 369 PQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTA 190
P+G +T VG+RG QLSGGQKQRIAIARA++RNPK+LLLDEATSALD++SEKVVQ ALD A
Sbjct: 1204 PEGFETRVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEKVVQEALDRA 1263
Query: 189 SERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
E + +V+AHRL+TV+NAD IAV+ NG + E+GTH +L+ ++ Y++L QKQ
Sbjct: 1264 REGRTCIVIAHRLNTVMNADCIAVVSNGTIIEKGTHTQLMSEKGAYYKLTQKQ 1316
Score = 306 bits (783), Expect = 3e-81
Identities = 189/520 (36%), Positives = 282/520 (53%), Gaps = 42/520 (8%)
Frame = -1
Query: 3363 FFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSV--STGHLSTVL 3190
F + A I + L M ++ T +R + +L + +FDS ++G +ST L
Sbjct: 800 FLVLAAAQGICSFLMTFFMGIASESLTRDLRNKLFRNVLSQHIGFFDSPQNASGKISTRL 859
Query: 3189 NDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAG 3010
++ R + + + +I + G LAF+ W++A I +AF ++
Sbjct: 860 ATDVPNLRTAIDFRFSTVITTLVSMVAGIGLAFFYGWQMALLIIAILPIVAFGQYLRGRR 919
Query: 3009 VMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMY 2830
K + +A++G IA + + +TV +L + T E + E+L K I+ A +
Sbjct: 920 FTGKNVKSASEFADSGKIAIEAIENVRTVQALAREDTFYENFCEKLDIPHKEAIKEAFIQ 979
Query: 2829 SISRGVTYFFCNSLNTVVLYVGATMIYSG--TLETAVVVRDDNVIEKDE------TDYDV 2674
+S G LNT +G +I + T++ V+R I T Y
Sbjct: 980 GLSYGCASSVLYLLNTCAYRMGLALIITDPPTMQPMRVLRVMYAITISTSTLGFATSYFP 1039
Query: 2673 EV------------------------------EVNGNISFKNVKFSYPTRPDAQVLKGIS 2584
E ++ G + FKNV+F+YP RP+ ++LKG+S
Sbjct: 1040 EYAKATFAGGIIFGMLRKISKIDSLSLAGEKKKLYGKVIFKNVRFAYPERPEIEILKGLS 1099
Query: 2583 FDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVS 2404
F V+ G+ +ALVG SG GKSTVV LL +Y+ G IFIDG ++ +N + R I +VS
Sbjct: 1100 FSVEPGQTLALVGPSGCGKSTVVALLERFYDTLGGEIFIDGSEIKTLNPEHTRSQIAIVS 1159
Query: 2403 QEPVLFNTTIEENIRFG--NPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLS 2230
QEP LF+ +I ENI +G +V++ ++ A R AN ++F+ P+G +T VG+RGTQLS
Sbjct: 1160 QEPTLFDCSIAENIIYGLDPSSVTMAQVEEAARLANIHNFIAELPEGFETRVGDRGTQLS 1219
Query: 2229 GGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTI 2050
GGQKQRIAIAR LVRNPKILLLDEATSALD ESE+VVQ+AL+ A +GRT IV+AHRL+T+
Sbjct: 1220 GGQKQRIAIARALVRNPKILLLDEATSALDTESEKVVQEALDRAREGRTCIVIAHRLNTV 1279
Query: 2049 RNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLE 1930
NA I V+ G I+E G H +L++++G Y L Q Q+ E
Sbjct: 1280 MNADCIAVVSNGTIIEKGTHTQLMSEKGAYYKLTQKQMTE 1319
>gi|283551|pir||S27337 multidrug resistance protein A - Caenorhabditis
elegans
gi|6809|emb|CAA46190.1| P-glycoprotein A [Caenorhabditis elegans]
Length = 1321
Score = 831 bits (2147), Expect = 0.0
Identities = 477/1253 (38%), Positives = 716/1253 (57%), Gaps = 67/1253 (5%)
Frame = -1
Query: 3588 VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNK--TIDPADL 3415
+++ ++ EK L +G L +++TG P MS G+VSQ + INN T P
Sbjct: 65 LYRYTTTLEKLLLFIGTLVAVITGAGLPLMSILQGKVSQAFINEQIVINNNGSTFLPTGQ 124
Query: 3414 EKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDA 3235
++E + VV+ + + + YV + R+R++++ +L+++
Sbjct: 125 NYTKTDFEHDVMNVVWSYAAMTVGMWAAGQIIVTCYLYVAEQMNNRLRREFVKSILRQEI 184
Query: 3234 QYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIF 3055
+FD+ +G L+T L DNLER +E +KI + +++ F G +AF W+L +
Sbjct: 185 SWFDTNHSGTLATKLFDNLERVKEGTGDKIGMAFQYLSQFITGFIVAFTHSWQLTLVMLA 244
Query: 3054 FSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEE 2875
+ A GF + + ++ YA AG + +T+ + +TV SLNG + E+ERY+
Sbjct: 245 VTPIQALCGFAIAKSMSTFAIRETLRYAKAGKVVEETISSIRTVVSLNGLRYELERYSTA 304
Query: 2874 LKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYSGTL-------------- 2737
++ +K G+ + L IS G + Y+G ++ G+L
Sbjct: 305 VEEAKKAGVLKGLFLGISFGAMQASNFISFALAFYIGVGWVHDGSLNFGDMLTTFSSVMM 364
Query: 2736 ----------ETAV-------------VVRDDNVIEKDETDYDVEVEVNGNISFKNVKFS 2626
+ AV V+ VI+ ++++ G+I+ +NV F+
Sbjct: 365 GSMALGLAGPQLAVLGTAQGAASGIYEVLDRKPVIDSSSKAGRKDMKIKGDITVENVHFT 424
Query: 2625 YPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLND 2446
YP+RPD +L+G++ V G+ +ALVG+SG GKST++ LLL YY++ G I IDG+D+ D
Sbjct: 425 YPSRPDVPILRGMNLRVNAGQTVALVGSSGCGKSTIISLLLRYYDVLKGKITIDGVDVRD 484
Query: 2445 MNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGI 2266
+N++ LR+ + VVSQEP LFN TIEENI G ++ E+ A + ANA F+ + P G
Sbjct: 485 INLEFLRKNVAVVSQEPALFNCTIEENISLGKEGITREEMVAACKMANAEKFIKTLPNGY 544
Query: 2265 KTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGR 2086
T+VG+RGTQLSGGQKQRIAIAR LVRNPKILLLDEATSALD ESE +VQ+AL+ A++GR
Sbjct: 545 NTLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAESEGIVQQALDKAAKGR 604
Query: 2085 TTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQ----------- 1939
TTI++AHRLSTIRNA II + G++VEVG+H L+A++G+Y DLV AQ
Sbjct: 605 TTIIIAHRLSTIRNADLIISCKNGQVVEVGDHRALMAQQGLYYDLVTAQTFTDAVDSAAE 664
Query: 1938 --------LLESHDDHEELPPLAARQLSQELSPLHSYAIQRSTS------NDAGVHDDDM 1801
+ +HE L A+ ++ ++ + S I T+ + + D +
Sbjct: 665 GKFSRENSVARQTSEHEGLSRQAS-EMDDIMNRVRSSTIGSITNGPVIDEKEERIGKDAL 723
Query: 1800 ERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFA 1621
R+ EL + A+K+NL EI+ RP LFI + + I G YP + FA
Sbjct: 724 SRLKQELEENNAQKTNLFEILYHARPHALSLFIGMSTATIGGFIYPTYSVFFTSFMNVFA 783
Query: 1620 MIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCA 1441
D L H WAL F+ LA + + + ++ G SE L+ LR K F ++LS
Sbjct: 784 GNPADFLSQGHFWALMFLVLAAAQGICSFLMTFFMGIASESLTRDLRNKLFRNVLSQHIG 843
Query: 1440 FYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVL 1261
F+D P +++ ++S RL TD N++ A+D R VI T+V++ I A Y W+M L ++
Sbjct: 844 FFDSPQNASGKISTRLATDVPNLRTAIDFRFSTVITTLVSMVAGIGLAFFYGWQMALLII 903
Query: 1260 MFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISE 1081
P + F +S + AIEA+ENVRTV+AL ED E
Sbjct: 904 AILPIVAFGQYLRGRRFTGKNVKSASEFADSGKIAIEAIENVRTVQALAREDTFYENFCE 963
Query: 1080 HLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALR--KEVAPMDTYLVLMT 907
L HK K A IQG + G + S + + +++ G L + + PM V+
Sbjct: 964 KLDIPHKEAIKEAFIQGLSYGCASSVLYLLNTCAYRMGLALIITDPPTMQPMRVLRVMYA 1023
Query: 906 LSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGENVQ 727
++++ + G A +Y P+Y KA A G+IF + + + S G+K G++I +NV+
Sbjct: 1024 ITISTSTLGFATSYFPEYAKATFAGGIIFGMLRKISKIDSLSLAGEKKKLYGKVIFKNVR 1083
Query: 726 FHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENV 547
F Y +RP+ IL G++ V+PG+TLALVGPSGCGKST+++LLERFY + GE+ ID +
Sbjct: 1084 FAYPERPEIEILKGLSFSVEPGQTLALVGPSGCGKSTVVALLERFYDTLGGEIFIDGSEI 1143
Query: 546 EDINLNHLRSNLALVSQEPTLFNCSIRENLLYGL-TRSVPQLELEKALQTANAFNFVFQF 370
+ +N H RS +A+VSQEPTLF+CSI EN++YGL SV ++E+A + AN NF+ +
Sbjct: 1144 KTLNPEHTRSQIAIVSQEPTLFDCSIAENIIYGLDPSSVTMAQVEEAARLANIHNFIAEL 1203
Query: 369 PQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTA 190
P+G +T VG+RG QLSGGQKQRIAIARA++RNPK+LLLDEATSALD++SEKVVQ ALD A
Sbjct: 1204 PEGFETRVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEKVVQEALDRA 1263
Query: 189 SERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
E + +V+AHRL+TV+NAD IAV+ NG + E+GTH +L+ ++ Y++L QKQ
Sbjct: 1264 REGRTCIVIAHRLNTVMNADCIAVVSNGTIIEKGTHTQLMSEKGAYYKLTQKQ 1316
Score = 306 bits (783), Expect = 3e-81
Identities = 189/520 (36%), Positives = 282/520 (53%), Gaps = 42/520 (8%)
Frame = -1
Query: 3363 FFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSV--STGHLSTVL 3190
F + A I + L M ++ T +R + +L + +FDS ++G +ST L
Sbjct: 800 FLVLAAAQGICSFLMTFFMGIASESLTRDLRNKLFRNVLSQHIGFFDSPQNASGKISTRL 859
Query: 3189 NDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAG 3010
++ R + + + +I + G LAF+ W++A I +AF ++
Sbjct: 860 ATDVPNLRTAIDFRFSTVITTLVSMVAGIGLAFFYGWQMALLIIAILPIVAFGQYLRGRR 919
Query: 3009 VMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMY 2830
K + +A++G IA + + +TV +L + T E + E+L K I+ A +
Sbjct: 920 FTGKNVKSASEFADSGKIAIEAIENVRTVQALAREDTFYENFCEKLDIPHKEAIKEAFIQ 979
Query: 2829 SISRGVTYFFCNSLNTVVLYVGATMIYSG--TLETAVVVRDDNVIEKDE------TDYDV 2674
+S G LNT +G +I + T++ V+R I T Y
Sbjct: 980 GLSYGCASSVLYLLNTCAYRMGLALIITDPPTMQPMRVLRVMYAITISTSTLGFATSYFP 1039
Query: 2673 EV------------------------------EVNGNISFKNVKFSYPTRPDAQVLKGIS 2584
E ++ G + FKNV+F+YP RP+ ++LKG+S
Sbjct: 1040 EYAKATFAGGIIFGMLRKISKIDSLSLAGEKKKLYGKVIFKNVRFAYPERPEIEILKGLS 1099
Query: 2583 FDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVS 2404
F V+ G+ +ALVG SG GKSTVV LL +Y+ G IFIDG ++ +N + R I +VS
Sbjct: 1100 FSVEPGQTLALVGPSGCGKSTVVALLERFYDTLGGEIFIDGSEIKTLNPEHTRSQIAIVS 1159
Query: 2403 QEPVLFNTTIEENIRFG--NPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLS 2230
QEP LF+ +I ENI +G +V++ ++ A R AN ++F+ P+G +T VG+RGTQLS
Sbjct: 1160 QEPTLFDCSIAENIIYGLDPSSVTMAQVEEAARLANIHNFIAELPEGFETRVGDRGTQLS 1219
Query: 2229 GGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTI 2050
GGQKQRIAIAR LVRNPKILLLDEATSALD ESE+VVQ+AL+ A +GRT IV+AHRL+T+
Sbjct: 1220 GGQKQRIAIARALVRNPKILLLDEATSALDTESEKVVQEALDRAREGRTCIVIAHRLNTV 1279
Query: 2049 RNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLE 1930
NA I V+ G I+E G H +L++++G Y L Q Q+ E
Sbjct: 1280 MNADCIAVVSNGTIIEKGTHTQLMSEKGAYYKLTQKQMTE 1319
>gi|39587899|emb|CAE67917.1| Hypothetical protein CBG13514
[Caenorhabditis briggsae]
Length = 1319
Score = 831 bits (2146), Expect = 0.0
Identities = 474/1254 (37%), Positives = 722/1254 (56%), Gaps = 68/1254 (5%)
Frame = -1
Query: 3588 VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAIN--NKTIDPADL 3415
+++ ++ EK + L+G + +++TG P MS G+VSQ + IN N TI P
Sbjct: 65 LYRYTTMTEKIMLLVGTIVAIITGAGLPLMSILQGQVSQAFINEQIVINTGNHTIPPNGR 124
Query: 3414 EKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDA 3235
++ + QVV+ + + + YV + R+R++++ +L++D
Sbjct: 125 NYTDSDFNHDVMQVVWLYAGMTIGMWAAGQITVTCYLYVAEQMNNRLRREFVKAILRQDI 184
Query: 3234 QYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIF 3055
+FD+ +G L+T L DNLER +E +KI + +++ F G +AF W+L +
Sbjct: 185 SWFDTNHSGTLATKLFDNLERVKEGTGDKIGMAFQYMSQFITGFIVAFTHSWKLTLVMLA 244
Query: 3054 FSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEE 2875
+ A GF+ + + ++ YA AG + +T+ + +TV SLNG + E+ERY+
Sbjct: 245 VTPIQALCGFLIAKSMSTFAIRETVRYAKAGKVVEETISSIRTVVSLNGLRHELERYSTA 304
Query: 2874 LKAGEKYGIRRALMYSISRGV---TYFFCNSLNTVVLYVGATMIYSGTL----------- 2737
++ +K G+ + L IS G T FF +L Y+G ++ G+L
Sbjct: 305 VEEAKKSGVLKGLFLGISFGAMQATNFFSFAL---AFYIGVGWVHDGSLAPGDMLTTFSS 361
Query: 2736 -------------ETAV-------------VVRDDNVIEKDETDYDVEVEVNGNISFKNV 2635
+ AV V+ VI+ + ++++ G+I+ +NV
Sbjct: 362 VMMGSMALGLAGPQLAVLGTAQGAASSIYEVLDRKPVIDSSSSAGRKDMKIKGDITVENV 421
Query: 2634 KFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMD 2455
F+YP+R D +L+G++ V G+ +ALVG+SG GKST++ LLL YY++ GNI IDG+D
Sbjct: 422 HFTYPSRQDVPILRGMNLRVNAGQTVALVGSSGCGKSTIISLLLRYYDVLKGNITIDGVD 481
Query: 2454 LNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFP 2275
+ D+N++ LR + VVSQEP LFN TIEENIR G +++ E+ A + ANA F+ + P
Sbjct: 482 VRDINLEFLRTNVAVVSQEPALFNCTIEENIRLGREDITREEMIAACKMANAEKFIKTLP 541
Query: 2274 KGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENAS 2095
G T+VG+RGTQLSGGQKQRIAIAR LVRNPKILLLDEATSALD ESE +VQ+AL+ A+
Sbjct: 542 AGYNTLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAESEGIVQQALDKAA 601
Query: 2094 QGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQ-------- 1939
+GRTTI++AHRLSTIRNA II + G++VEVG+H L+A+ G+Y DLV AQ
Sbjct: 602 KGRTTIIIAHRLSTIRNADLIISCKNGQVVEVGDHRTLMAQEGLYYDLVTAQTFTDAVDA 661
Query: 1938 -----------LLESHDDHEELPPLAARQLSQELSPLHSYAIQRSTS------NDAGVHD 1810
+ +HE + A+ +L L+ + S + T+ + +
Sbjct: 662 SAGGKFSRENSIARQTSEHEGIFRQAS-ELDDVLNRVRSSTMGSITNGPVIEEKEQRIGK 720
Query: 1809 DDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYE 1630
D + R+ +EL + A+++NL EI+ +P + I + + + G YP +
Sbjct: 721 DALTRLKEELEENNAQRTNLFEILYHAKPHALSVAIGITAAIVGGFIYPTYSVFFTSFIN 780
Query: 1629 GFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSL 1450
F+ +D+L H WAL F+ LA + + + ++ G SE L+ LR K F ++LS
Sbjct: 781 VFSGNPDDILSQGHFWALMFLVLAAAQGICSFLMTFFMGIASESLTMDLRNKLFRNVLSQ 840
Query: 1449 PCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTL 1270
F+D P +++ ++ RL TD N++ A+D R VI T+V++ I A Y W+M L
Sbjct: 841 HIGFFDSPQNASGKICTRLATDVPNLRTAIDFRFSTVITTLVSMIAGIGLAFYYGWQMAL 900
Query: 1269 EVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSL 1090
++ P + F +S + AIEA+ENVRTV+AL ED
Sbjct: 901 LIVAILPIVGFGQYLRGRRFTGNNVKSASEFADSGKIAIEAIENVRTVQALAREDTFYYK 960
Query: 1089 ISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLM 910
L HK K A IQG + G + S + + +++ G L L + + PM V+
Sbjct: 961 FCSKLDVPHKEAIKEAFIQGLSYGCACSVLYLLNTCAYRMGLALILHRTMTPMRVLRVMY 1020
Query: 909 TLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGENV 730
++++ + G A +Y P+Y KA A G+IF + + + + G+K G++I +NV
Sbjct: 1021 AITISTSTLGFATSYFPEYAKATFAGGIIFGMLKQKSEIDSLTLSGEKKKLSGKVIFKNV 1080
Query: 729 QFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSEN 550
+F Y +RP IL G++ VDPG+TLALVGPSGCGKST+++LLERFY + GEV ID
Sbjct: 1081 RFAYPERPQIEILKGLSFSVDPGQTLALVGPSGCGKSTVVALLERFYDTLAGEVFIDGSE 1140
Query: 549 VEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGL-TRSVPQLELEKALQTANAFNFVFQ 373
++ +N + RS +A+VSQEPTLF+CSI EN++YGL +V +E+A + AN NF+ +
Sbjct: 1141 IKTLNPENTRSQIAIVSQEPTLFDCSIAENIVYGLDPTTVTMSRVEEAAKLANIHNFISE 1200
Query: 372 FPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDT 193
P+G +T VG+RG QLSGGQKQRIAIARA++RNPK+LLLDEATSALD++SEK+VQ ALD
Sbjct: 1201 LPEGYETRVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEKIVQEALDR 1260
Query: 192 ASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
A E + +V+AHRL+T++NAD IAV+ NG + EQGTH L+ ++ Y++L QKQ
Sbjct: 1261 AREGRTCIVIAHRLNTIMNADCIAVVNNGTIIEQGTHSVLMSQQGAYYKLTQKQ 1314
Score = 300 bits (768), Expect = 2e-79
Identities = 194/579 (33%), Positives = 297/579 (50%), Gaps = 40/579 (6%)
Frame = -1
Query: 3546 LGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQVVF 3367
+G+ +++ GF P S F T+ IN + +P D+ +
Sbjct: 756 IGITAAIVGGFIYPTYSVFF----------TSFINVFSGNPDDILSQGHFW-------AL 798
Query: 3366 HFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSV--STGHLSTV 3193
F + A I + L M ++ T +R + +L + +FDS ++G + T
Sbjct: 799 MFLVLAAAQGICSFLMTFFMGIASESLTMDLRNKLFRNVLSQHIGFFDSPQNASGKICTR 858
Query: 3192 LNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSA 3013
L ++ R + + + +I + G LAFY W++A + + F ++
Sbjct: 859 LATDVPNLRTAIDFRFSTVITTLVSMIAGIGLAFYYGWQMALLIVAILPIVGFGQYLRGR 918
Query: 3012 GVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALM 2833
K + +A++G IA + + +TV +L + T ++ +L K I+ A +
Sbjct: 919 RFTGNNVKSASEFADSGKIAIEAIENVRTVQALAREDTFYYKFCSKLDVPHKEAIKEAFI 978
Query: 2832 YSISRGVTYFFCNSLNTVVLYVGATMIYSGTLETAVVVRDDNVI---------------- 2701
+S G LNT +G +I T+ V+R I
Sbjct: 979 QGLSYGCACSVLYLLNTCAYRMGLALILHRTMTPMRVLRVMYAITISTSTLGFATSYFPE 1038
Query: 2700 ----------------EKDETDY----DVEVEVNGNISFKNVKFSYPTRPDAQVLKGISF 2581
+K E D + +++G + FKNV+F+YP RP ++LKG+SF
Sbjct: 1039 YAKATFAGGIIFGMLKQKSEIDSLTLSGEKKKLSGKVIFKNVRFAYPERPQIEILKGLSF 1098
Query: 2580 DVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQ 2401
V G+ +ALVG SG GKSTVV LL +Y+ +G +FIDG ++ +N + R I +VSQ
Sbjct: 1099 SVDPGQTLALVGPSGCGKSTVVALLERFYDTLAGEVFIDGSEIKTLNPENTRSQIAIVSQ 1158
Query: 2400 EPVLFNTTIEENIRFG--NPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSG 2227
EP LF+ +I ENI +G V++ + A + AN ++F+ P+G +T VG+RGTQLSG
Sbjct: 1159 EPTLFDCSIAENIVYGLDPTTVTMSRVEEAAKLANIHNFISELPEGYETRVGDRGTQLSG 1218
Query: 2226 GQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIR 2047
GQKQRIAIAR LVRNPKILLLDEATSALD ESE++VQ+AL+ A +GRT IV+AHRL+TI
Sbjct: 1219 GQKQRIAIARALVRNPKILLLDEATSALDTESEKIVQEALDRAREGRTCIVIAHRLNTIM 1278
Query: 2046 NASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLE 1930
NA I V+ G I+E G H L++++G Y L Q Q+ E
Sbjct: 1279 NADCIAVVNNGTIIEQGTHSVLMSQQGAYYKLTQKQMSE 1317
>gi|39594783|emb|CAE70651.1| Hypothetical protein CBG17356
[Caenorhabditis briggsae]
Length = 1265
Score = 778 bits (2008), Expect = 0.0
Identities = 452/1240 (36%), Positives = 708/1240 (56%), Gaps = 54/1240 (4%)
Frame = -1
Query: 3588 VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEK 3409
+F+ S C + L L G++FS +G PF S F ++ VL+ + N T
Sbjct: 32 LFRHSDCLDYLLLLGGIVFSSASGALLPFNSLIFEGITNVLMQGQSEWQNGTF------- 84
Query: 3408 AYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQY 3229
AY+ + G+ +FL G F+ + +A + + + Y +RK + +L++DAQ+
Sbjct: 85 AYDTFSTGIRHYCLLYFLLGVFMFLCTYISNACLYTMAERRLYCIRKHLLRSVLRQDAQW 144
Query: 3228 FDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFS 3049
FD + G L+ ++ +E+ ++ +KI ++ + F G L FY W+L +
Sbjct: 145 FDENTVGGLTQKMSSGIEKIKDGIGDKIGVLFSGAATFISGVLLGFYMCWQLTLVMLITV 204
Query: 3048 LGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELK 2869
++++ + + T + + Y++AG +A + + +TV + N Q EI RY ++L
Sbjct: 205 PLQLGQMYMSAKHLNRATKNEMSAYSSAGGMANEVIAGIRTVIAFNAQPFEISRYADKLA 264
Query: 2868 AGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIY-----SGT------------ 2740
+ GIR++++ + V L + GA + SGT
Sbjct: 265 EARQMGIRKSIVLASCSAVPLVLMFVLMAGAFWYGAILTSFGIATSGTTFGVFWAVLLGT 324
Query: 2739 -------------LETAVVVRDDNVIEKDETDYDVEVE-------VNGNISFKNVKFSYP 2620
L + + D + +E + + E +NG ++F N++F+YP
Sbjct: 325 RRLGEAAPHMGAILGARLAINDIFKVIDNEPEINCTKETGRRPEKINGKLNFDNIEFTYP 384
Query: 2619 TRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMN 2440
TRPD ++LKG+SF+V GE +ALVG SG GKST + LL+ +YN +G I +DG+ + D N
Sbjct: 385 TRPDVKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGTIKLDGVPIEDYN 444
Query: 2439 IKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKT 2260
I+ LR IG+V QEP++F T+ ENIR G+ +++ +I A R+ANA+DF+ G T
Sbjct: 445 IQWLRSTIGIVQQEPIIFLATVSENIRMGDNSITDKDIEDACRQANAHDFIGHLSDGYNT 504
Query: 2259 IVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTT 2080
I+G QLSGGQKQR+AIAR +VR P+ILLLDEATSALD ESE++VQ AL+ ASQGRTT
Sbjct: 505 IIGAGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQAALDKASQGRTT 564
Query: 2079 IVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLES-------HD 1921
+ +AHRLSTIRNA+KI+V +G IVE G HD+LI + G+Y +V+AQ +E D
Sbjct: 565 LCIAHRLSTIRNANKILVFDQGLIVEKGTHDQLIRQNGIYASMVRAQEIERAKEDTVVED 624
Query: 1920 D--HEELPPLAARQLSQELSPLHSYAIQRST--------SNDAGVHDDDMERILDELSKE 1771
D EE ++ R + E S ++ R + S + V D ++E +E+ +E
Sbjct: 625 DSLEEETQSISRRLSTSEDEVRKSKSLLRDSARLSQSMLSVTSQVPDWEVEIAREEMFEE 684
Query: 1770 GAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYYS 1591
GA ++++ +I + +P+ + IA+ + I+G+++P + + + ++ FA GED+ +
Sbjct: 685 GAMEASMMDIFRFAKPEKWNVIIALIVTLIRGITWPAFSVVYGQLFKVFAEGGEDLPTNA 744
Query: 1590 HLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSAT 1411
+ +L F+ LA +T + GK E +S+RLR+ F +++ +++D+P H+
Sbjct: 745 FVSSLWFILLAFTSGITTFISGSLLGKTGETMSSRLRLNVFKNIMQQDASYFDEPKHNVG 804
Query: 1410 RLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXX 1231
L+ RL TDS NV+AA+D RL V+ V+++ I A + W M L+
Sbjct: 805 NLTARLATDSQNVQAAIDHRLAEVLNGVISLFAGIAVAFWFGWSMAPIGLLTALLLVIAQ 864
Query: 1230 XXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYF 1051
+D + ++R E++ N +TV+AL ++ + + +K + F
Sbjct: 865 SSVAQYLKYRGPKDMESAIEASRIVTESISNWKTVQALTKQEYMYGAFTTASKKPRQRAF 924
Query: 1050 KRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAA 871
+ + Q + L+ S FL+ +++++ FG +L P + V+ L+M + AA
Sbjct: 925 AKGLWQSLSFALAGSFFLWNFAIAYMFGLWLISNNWTTPFAVFQVIEALNMASMSVMMAA 984
Query: 870 AYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMIL 691
+Y P+Y +A +AG++F + + + G+ + KG+I V F Y R ++IL
Sbjct: 985 SYFPEYVRARISAGIMFTMIRQKSAIDNRGLTGETPLIKGDISMRGVYFAYPNRKRQLIL 1044
Query: 690 NGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNL 511
N N+ + G+T+ALVGPSGCGKST I L+ER+Y AV G V+ID +V DI++ HLR N+
Sbjct: 1045 NNFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDAVCGSVRIDDTDVRDISVKHLRDNI 1104
Query: 510 ALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGA 331
ALV QEPTLFN SIREN+ YGL +V Q ++E+A + AN NFV P+G DT VG G
Sbjct: 1105 ALVGQEPTLFNLSIRENITYGL-ENVSQEQIEEAAKLANIHNFVISLPEGYDTSVGASGG 1163
Query: 330 QLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRL 151
+LSGGQKQRIAIARAI+R+PK+LLLDEATSALDS+SEK+VQ ALD A + VV+AHRL
Sbjct: 1164 RLSGGQKQRIAIARAIVRDPKILLLDEATSALDSESEKIVQEALDKARLGRTCVVIAHRL 1223
Query: 150 STVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
ST+ NAD I V +NGK E+GTH+ LL +R +Y+RLV+KQ
Sbjct: 1224 STIQNADKIIVCRNGKAIEEGTHQSLLARRGLYYRLVEKQ 1263
Score = 279 bits (713), Expect = 4e-73
Identities = 165/522 (31%), Positives = 280/522 (53%), Gaps = 1/522 (0%)
Frame = -1
Query: 1584 WALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRL 1405
+ L + L VF L Y ++E+ +R +L ++D+ ++ L
Sbjct: 96 YCLLYFLLGVFMFLCTYISNACLYTMAERRLYCIRKHLLRSVLRQDAQWFDE--NTVGGL 153
Query: 1404 SNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXX 1225
+ ++++ +K + D++G + + CW++TL +L+ P
Sbjct: 154 TQKMSSGIEKIKDGIGDKIGVLFSGAATFISGVLLGFYMCWQLTLVMLITVPLQLGQMYM 213
Query: 1224 XXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKR 1045
A + + A+ ++ A E + +RTV A N + +S ++ L + + ++
Sbjct: 214 SAKHLNRATKNEMSAYSSAGGMANEVIAGIRTVIAFNAQPFEISRYADKLAEARQMGIRK 273
Query: 1044 AIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAY 865
+I+ + + + L + + +F +G L T+ V + + G AA +
Sbjct: 274 SIVLASCSAVPLVLMFVLMAGAFWYGAILTSFGIATSGTTFGVFWAVLLGTRRLGEAAPH 333
Query: 864 LPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIE-KGEIIGENVQFHYDQRPDRMILN 688
+ A A IF + + + G++ + G++ +N++F Y RPD IL
Sbjct: 334 MGAILGARLAINDIFKVIDNEPEINCTKETGRRPEKINGKLNFDNIEFTYPTRPDVKILK 393
Query: 687 GVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLA 508
GV+ +V+PG+T+ALVG SGCGKST I LL RFY+ G +K+D +ED N+ LRS +
Sbjct: 394 GVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGTIKLDGVPIEDYNIQWLRSTIG 453
Query: 507 LVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQ 328
+V QEP +F ++ EN+ G S+ ++E A + ANA +F+ G +T++G Q
Sbjct: 454 IVQQEPIIFLATVSENIRMG-DNSITDKDIEDACRQANAHDFIGHLSDGYNTIIGAGAVQ 512
Query: 327 LSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLS 148
LSGGQKQR+AIARAI+R P++LLLDEATSALD++SE++VQ ALD AS+ +T+ +AHRLS
Sbjct: 513 LSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQAALDKASQGRTTLCIAHRLS 572
Query: 147 TVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQ 22
T+ NA+ I V G + E+GTH++L+R+ IY +V+ Q I+
Sbjct: 573 TIRNANKILVFDQGLIVEKGTHDQLIRQNGIYASMVRAQEIE 614
>gi|17569145|ref|NP_509902.1| P-GlycoProtein related (pgp-4)
[Caenorhabditis elegans]
gi|7503247|pir||T22090 hypothetical protein F42E11.1 - Caenorhabditis
elegans
gi|3877005|emb|CAA91463.1| Hypothetical protein F42E11.1
[Caenorhabditis elegans]
Length = 1266
Score = 777 bits (2006), Expect = 0.0
Identities = 455/1241 (36%), Positives = 710/1241 (56%), Gaps = 55/1241 (4%)
Frame = -1
Query: 3588 VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEK 3409
+F+ S C + L L G++ S G PF S F ++ VL+ N T D
Sbjct: 32 LFRHSGCADYLLLLGGLVLSAANGALLPFNSLIFEGITNVLMKGEAQWQNGTFD------ 85
Query: 3408 AYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQY 3229
Y+ + G+ +FL G F +A + + + Y +RK + +L++DA++
Sbjct: 86 -YDTFSSGIQHYCLLYFLLGVLMFTCTYFSNACLFTMAERRLYCIRKHLLQSVLRQDAKW 144
Query: 3228 FDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFS 3049
FD + G L+ ++ +E+ ++ +KI ++++ + F G AL FY W+L +
Sbjct: 145 FDENTVGGLTQKMSSGIEKIKDGIGDKIGVLVSGIATFISGVALGFYMCWQLTLVMLVTV 204
Query: 3048 LGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELK 2869
S ++++ + + T + + Y++AG +A + + +TV + N Q EIERY +L
Sbjct: 205 PLQLGSMYLSAKHLNRATKNEMSAYSSAGGMANEVIAGIRTVIAFNAQPFEIERYGAQLA 264
Query: 2868 AGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYSGTLET--------AVVVRD 2713
K GIR+A++ ++ + F L + GA + G + AV++
Sbjct: 265 KARKMGIRKAIVLALCSAMPLFLMFVLMAGAFWYGAILTSYGVATSGTTFGVFWAVILGT 324
Query: 2712 DNVIEKDE------------------TDYDVEV-----------EVNGNISFKNVKFSYP 2620
+ E D++ E+ +VNG + F N++F+YP
Sbjct: 325 RRLGEAAPHMGAITGARLAVNDIFKVIDHEPEINCTKQEGRRPDKVNGKLVFDNIQFTYP 384
Query: 2619 TRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMN 2440
TRPD ++LKG+SF+V GE IALVG SG GKST + LL+ +YN +G+I +DG+ + D N
Sbjct: 385 TRPDVKILKGVSFEVNPGETIALVGHSGCGKSTSIGLLMRFYNQCAGSIKLDGIPIEDYN 444
Query: 2439 IKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKT 2260
I+ LR IG+V QEP++F T+ EN+R G+ +++ +I A R+ANA+DF+ +G T
Sbjct: 445 IQWLRSTIGIVQQEPIIFLATVAENVRMGDDSITDKDIENACRQANAHDFIGKLSEGYNT 504
Query: 2259 IVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTT 2080
++G QLSGGQKQR+AIAR +VR P+ILLLDEATSALD ESE++VQ AL+ AS+GRTT
Sbjct: 505 VIGAGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTT 564
Query: 2079 IVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLE-----SHDDH 1915
+ +AHRLSTIRNASKI+V +G I E G HD+LI + G+Y ++V+AQ +E + D
Sbjct: 565 LCIAHRLSTIRNASKILVFDQGLIPERGIHDQLIRQNGIYANMVRAQEIEKAKDDTTQDD 624
Query: 1914 EELPPLAARQLSQELSPLH-----SYAIQRST--------SNDAGVHDDDMERILDELSK 1774
+EL +S+ LS S ++ R + S + V D +ME +E+ +
Sbjct: 625 DELVEEDNYSISRRLSTSEEELRKSKSLLRDSTRFSQSMLSVTSQVPDWEMESAREEMIE 684
Query: 1773 EGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYY 1594
EGA ++++ +I + +P+ + IA+ + I+G+++P + + + ++ FA GED+
Sbjct: 685 EGAMEASMMDIFRFAKPEKMNIVIALIFTLIRGITWPAFSVVYGQLFKVFAEGGEDLPVN 744
Query: 1593 SHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSA 1414
+ + +L F+ LAV +T + GK E +S+RLR+ F +++ ++DDP H+
Sbjct: 745 ALISSLWFVLLAVTSAVTTFISGSLLGKTGETMSSRLRMDVFKNIMQQDATYFDDPKHNV 804
Query: 1413 TRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXX 1234
L++RL TDS NV+AA+D RL V+ VV++ I A + W M L+
Sbjct: 805 GNLTSRLATDSQNVQAAIDHRLAEVLNGVVSLFTGIAVAFWFGWSMAPIGLITALLLVIA 864
Query: 1233 XXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSY 1054
+D + ++R E++ N +TV+AL ++ + + + K
Sbjct: 865 QSAVAQYLKYRGPKDMESAIEASRIVTESISNWKTVQALTKQEYMFHAFTAASKNPRKRA 924
Query: 1053 FKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSA 874
F + + Q + L+ S FL+ +++++ FG +L P + V+ L+M + A
Sbjct: 925 FTKGLWQSLSFALAGSFFLWNFAIAYMFGLWLISNNWTTPFAVFQVIEALNMASMSVMMA 984
Query: 873 AAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMI 694
A+Y P+Y +A +AG++F + A + G+ +G+I + V F Y R ++I
Sbjct: 985 ASYFPEYVRARISAGIMFTMIRQKAKIDNRGLTGETPDIRGDISMKGVYFAYPNRNRQLI 1044
Query: 693 LNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSN 514
LN N+ G+T+ALVGPSGCGKST I L+ER+Y A+ G VKID ++ DI++ HLR N
Sbjct: 1045 LNNFNMSAQFGETVALVGPSGCGKSTSIQLIERYYDAICGAVKIDDHDIRDISVKHLRHN 1104
Query: 513 LALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERG 334
+ALV QEPTLFN +IREN+ YGL +V Q ++EKA AN +FV P+G DT VG G
Sbjct: 1105 IALVGQEPTLFNLTIRENITYGL-ENVSQEQVEKAATLANIHSFVENLPEGYDTSVGASG 1163
Query: 333 AQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHR 154
+LSGGQKQRIAIARAI+RNPK+LLLDEATSALD++SEK+VQ ALD A + VV+AHR
Sbjct: 1164 GRLSGGQKQRIAIARAIVRNPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHR 1223
Query: 153 LSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
LST+ NAD I V +NGK E+GTH+ LL +R +Y+RLV+KQ
Sbjct: 1224 LSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 1264
Score = 287 bits (734), Expect = 1e-75
Identities = 158/463 (34%), Positives = 259/463 (55%), Gaps = 1/463 (0%)
Frame = -1
Query: 1407 LSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXX 1228
L+ ++++ +K + D++G ++ + + CW++TL +L+ P
Sbjct: 153 LTQKMSSGIEKIKDGIGDKIGVLVSGIATFISGVALGFYMCWQLTLVMLVTVPLQLGSMY 212
Query: 1227 XXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFK 1048
A + + A+ ++ A E + +RTV A N + + L K K +
Sbjct: 213 LSAKHLNRATKNEMSAYSSAGGMANEVIAGIRTVIAFNAQPFEIERYGAQLAKARKMGIR 272
Query: 1047 RAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAA 868
+AI+ + + L + + +F +G L T+ V + + G AA
Sbjct: 273 KAIVLALCSAMPLFLMFVLMAGAFWYGAILTSYGVATSGTTFGVFWAVILGTRRLGEAAP 332
Query: 867 YLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIE-KGEIIGENVQFHYDQRPDRMIL 691
++ A A IF + + + + +G++ + G+++ +N+QF Y RPD IL
Sbjct: 333 HMGAITGARLAVNDIFKVIDHEPEINCTKQEGRRPDKVNGKLVFDNIQFTYPTRPDVKIL 392
Query: 690 NGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNL 511
GV+ +V+PG+T+ALVG SGCGKST I LL RFY+ G +K+D +ED N+ LRS +
Sbjct: 393 KGVSFEVNPGETIALVGHSGCGKSTSIGLLMRFYNQCAGSIKLDGIPIEDYNIQWLRSTI 452
Query: 510 ALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGA 331
+V QEP +F ++ EN+ G S+ ++E A + ANA +F+ + +G +T++G
Sbjct: 453 GIVQQEPIIFLATVAENVRMG-DDSITDKDIENACRQANAHDFIGKLSEGYNTVIGAGAV 511
Query: 330 QLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRL 151
QLSGGQKQR+AIARAI+R P++LLLDEATSALD++SE++VQ ALD ASE +T+ +AHRL
Sbjct: 512 QLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCIAHRL 571
Query: 150 STVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQ 22
ST+ NA I V G + E+G H++L+R+ IY +V+ Q I+
Sbjct: 572 STIRNASKILVFDQGLIPERGIHDQLIRQNGIYANMVRAQEIE 614
>gi|1362689|pir||S55692 multidrug resistance protein homolog (mdr) -
African clawed frog
Length = 1287
Score = 771 bits (1992), Expect = 0.0
Identities = 464/1266 (36%), Positives = 705/1266 (55%), Gaps = 51/1266 (4%)
Frame = -1
Query: 3675 EENSNNFSTPLLPQSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMS 3496
+E FS + +KP ++ F +F+ SS +K L L G + SL G P M
Sbjct: 27 KEKKGFFSKFKKKKEKTEKPPKVGVF--TMFRYSSTSDKMLMLFGTIASLAHGAALPLMM 84
Query: 3495 YTFGEVSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQH 3316
FGE++ V + ++ + A E + M +++ G + A +Q
Sbjct: 85 LVFGEMTDSFVNV-GQVDTGNFTWESMINASRELQGQMTTYAYYYSGLGFGVMLCAYIQI 143
Query: 3315 AIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALI 3136
+ ++R + +L+++ +FD G L+T L D++ + E +KIA++
Sbjct: 144 SFWTLSAGRQIKKIRSNFFHAVLRQEIGWFDINDAGELNTRLTDDVSKINEGIGDKIAML 203
Query: 3135 IAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSI 2956
+ +T G + F W+L S + S I + + T K+ YA AG++
Sbjct: 204 LQSLTTLVTGFIIGFIKGWKLTWVMGAISPIMGLSAAIWAKVLSAFTNKELKAYAKAGAV 263
Query: 2955 AFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVV 2776
A + L + +TV + GQ EI RY + L+ +K GI++A+ ++S G + + ++
Sbjct: 264 AEEVLSSIRTVFAFGGQNKEIHRYEKNLEDAKKIGIKKAITANVSIGFAFLMIYAAYSLA 323
Query: 2775 LYVGATMIYSG--------TLETAVVVRDDNVIEKDETDYDVEV---------------- 2668
+ G T+I G T+ AV++ +T ++E
Sbjct: 324 FWYGTTLIIDGGYTIGSVLTVFFAVII---GAFAVGQTSPNIEAFANARGAAYTIFNIID 380
Query: 2667 ----------------EVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASG 2536
++ G+I FKNV F+YP+R D QVLKG++ ++ +G+ +ALVG+SG
Sbjct: 381 NQPKIDSFSKEGLKPDKIKGDIEFKNVIFTYPSRKDIQVLKGLNLNIPSGKTVALVGSSG 440
Query: 2535 SGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRF 2356
GKST VQL+ +Y+ + G I +DG D+ +NI+ LR +IGVVSQEP+LF+TTI +NIR+
Sbjct: 441 CGKSTTVQLIQRFYDPEDGVITLDGQDIRSLNIRYLREIIGVVSQEPILFDTTIADNIRY 500
Query: 2355 GNPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPK 2176
G +V+ EI A ++ANAYDF+ P ++T+VGERGTQLSGGQKQRIAIAR LVRNPK
Sbjct: 501 GREDVTKEEIERATKEANAYDFIMKLPDKLETLVGERGTQLSGGQKQRIAIARALVRNPK 560
Query: 2175 ILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVG 1996
ILLLDEATSALD ESE VVQ AL+ A +GRTTIVVAHRLSTIRNA+ I G IVE G
Sbjct: 561 ILLLDEATSALDTESEAVVQSALDKAREGRTTIVVAHRLSTIRNANAIAGFDNGVIVEQG 620
Query: 1995 NHDELIAKRGVYNDLVQAQLLESHDDHEELPPLAARQLSQELSPLHSYAIQRSTSND--- 1825
+H EL+ + GVY +LV Q +E+ D EE + ++ HS ++R +S +
Sbjct: 621 SHKELMERGGVYFNLVTLQTVETSKDTEEDLETHIYEKKIPVTHTHSNLVRRKSSRNTIK 680
Query: 1824 AGVHDDDMERILDELSK--EGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQ 1651
+ V + + + + +E K EG + +++K +P++ + + V + I G + P A
Sbjct: 681 SKVPETEDKEVDEEEKKKEEGPPPVSFFKVMKLNKPEWPYFVVGVICAMINGATQPAFAI 740
Query: 1650 LIVRTYEGFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKS 1471
+ R FA M S +++L F+ L +T + Q + FGK E L+ RLR+ S
Sbjct: 741 IFSRIIGVFAGPVSQMRSESSMYSLLFLALGGVSFITFFLQRFTFGKAGEILTMRLRLGS 800
Query: 1470 FSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASL 1291
F ML ++DD +S L+ RL TD+S V+ A RL + V + AI + +
Sbjct: 801 FKSMLRQEIGWFDDSKNSTGALTTRLATDASQVQGATGTRLALLAQNVANLGTAIIISFI 860
Query: 1290 YCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNL 1111
Y W++TL +L P ++D E + + + +A+ N+RTV +L
Sbjct: 861 YGWQLTLLILAIVPVIAAAGLVEMKMFAGHAKKDKKELEKAGKISTDAVLNIRTVVSLTR 920
Query: 1110 EDKIMSLISEHLQKIHKSYFKRAIIQGAANGLS----LSCFLFVYSVSFKFGTYLALRKE 943
E K ++ + L+ +++ K+A + G GLS + C +V+SV G YL +
Sbjct: 921 ERKFEAMYEKSLEGPYRNSIKKAHLHGLTYGLSQAHHVLCLCWVFSV---LGAYLVVEGL 977
Query: 942 VAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLF-TYPATMPFSSSDGKK 766
+ + +LV + + A G +++ PDY KA+ +A IF L P +S K
Sbjct: 978 MKLDEVFLVSSAIVLGAMALGQTSSFAPDYTKAMISAAHIFSLLERVPQIDSYSDQGEKP 1037
Query: 765 NIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYH 586
G ++ + V F+Y RPD +L G+++ V G+TLALVG SGCGKST +SLLERFY
Sbjct: 1038 KNCSGNVVFKGVNFNYPTRPDITVLQGLDISVKQGETLALVGSSGCGKSTTVSLLERFYD 1097
Query: 585 AVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYG-LTRSVPQLELEKA 409
+GEV +D +V ++N+ +R+ + +VSQEP LF+CSI +N+ YG R V Q E+E A
Sbjct: 1098 PFEGEVLVDGLSVRNLNIQWVRAQMGIVSQEPILFDCSIGDNIAYGDNNRKVTQEEIETA 1157
Query: 408 LQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDS 229
+ AN +F+ +T VG++G QLSGGQKQRIAIARA++R PK+LLLDEATSALD+
Sbjct: 1158 AKEANIHSFIESLTDKYNTRVGDKGTQLSGGQKQRIAIARALIRKPKILLLDEATSALDT 1217
Query: 228 DSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYW 49
+SEKVVQ ALD A + +V+AHRLST+ NAD IAV++NGKV EQGTH++LL+ + +Y+
Sbjct: 1218 ESEKVVQEALDKARMGRTCIVIAHRLSTIQNADKIAVIQNGKVVEQGTHQQLLQLKGVYF 1277
Query: 48 RLVQKQ 31
LV Q
Sbjct: 1278 SLVTIQ 1283
Score = 313 bits (803), Expect = 1e-83
Identities = 196/590 (33%), Positives = 306/590 (51%), Gaps = 17/590 (2%)
Frame = -1
Query: 1722 DYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIG---------EDMLYYSH------ 1588
D + S G + P++ + + F +G E M+ S
Sbjct: 62 DKMLMLFGTIASLAHGAALPLMMLVFGEMTDSFVNVGQVDTGNFTWESMINASRELQGQM 121
Query: 1587 -LWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSAT 1411
+A + L L Y Q ++ + + ++R F +L ++D + A
Sbjct: 122 TTYAYYYSGLGFGVMLCAYIQISFWTLSAGRQIKKIRSNFFHAVLRQEIGWFDI--NDAG 179
Query: 1410 RLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXX 1231
L+ RL D S + + D++ ++ ++ + + WK+T + P
Sbjct: 180 ELNTRLTDDVSKINEGIGDKIAMLLQSLTTLVTGFIIGFIKGWKLTWVMGAISPIMGLSA 239
Query: 1230 XXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYF 1051
++ A+ + A E L ++RTV A ++K + ++L+ K
Sbjct: 240 AIWAKVLSAFTNKELKAYAKAGAVAEEVLSSIRTVFAFGGQNKEIHRYEKNLEDAKKIGI 299
Query: 1050 KRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAA 871
K+AI + G + YS++F +GT L + V + + A G +
Sbjct: 300 KKAITANVSIGFAFLMIYAAYSLAFWYGTTLIIDGGYTIGSVLTVFFAVIIGAFAVGQTS 359
Query: 870 AYLPDYKKAVHAAGLIFHLF-TYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMI 694
+ + A AA IF++ P FS K + KG+I +NV F Y R D +
Sbjct: 360 PNIEAFANARGAAYTIFNIIDNQPKIDSFSKEGLKPDKIKGDIEFKNVIFTYPSRKDIQV 419
Query: 693 LNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSN 514
L G+NL + GKT+ALVG SGCGKST + L++RFY DG + +D +++ +N+ +LR
Sbjct: 420 LKGLNLNIPSGKTVALVGSSGCGKSTTVQLIQRFYDPEDGVITLDGQDIRSLNIRYLREI 479
Query: 513 LALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERG 334
+ +VSQEP LF+ +I +N+ YG V + E+E+A + ANA++F+ + P L+TLVGERG
Sbjct: 480 IGVVSQEPILFDTTIADNIRYG-REDVTKEEIERATKEANAYDFIMKLPDKLETLVGERG 538
Query: 333 AQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHR 154
QLSGGQKQRIAIARA++RNPK+LLLDEATSALD++SE VVQ+ALD A E +T+VVAHR
Sbjct: 539 TQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQSALDKAREGRTTIVVAHR 598
Query: 153 LSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQVETPSD 4
LST+ NA++IA NG + EQG+H+EL+ + +Y+ LV Q VET D
Sbjct: 599 LSTIRNANAIAGFDNGVIVEQGSHKELMERGGVYFNLVTLQ--TVETSKD 646
Score = 290 bits (741), Expect = 2e-76
Identities = 194/583 (33%), Positives = 299/583 (51%), Gaps = 44/583 (7%)
Frame = -1
Query: 3552 FLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQV 3373
F++GV+ +++ G QP + F + V + + + E M +
Sbjct: 721 FVVGVICAMINGATQPAFAIIFSRIIGVFAGPVSQMRS---------------ESSMYSL 765
Query: 3372 VFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSV--STGHLS 3199
+F G FI LQ G+ T R+R +L+++ +FD STG L+
Sbjct: 766 LF--LALGGVSFITFFLQRFTFGKAGEILTMRLRLGSFKSMLRQEIGWFDDSKNSTGALT 823
Query: 3198 TVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFIN 3019
T L + + + ++AL+ V + ++F W+L + IA +G +
Sbjct: 824 TRLATDASQVQGATGTRLALLAQNVANLGTAIIISFIYGWQLTLLILAIVPVIAAAGLVE 883
Query: 3018 SAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRA 2839
K AG I+ + +TV SL ++ Y + L+ + I++A
Sbjct: 884 MKMFAGHAKKDKKELEKAGKISTDAVLNIRTVVSLTRERKFEAMYEKSLEGPYRNSIKKA 943
Query: 2838 LMYSISRGVT---YFFCNSLNTVVLYVGATMIYSGTLET-------------AVVVRDDN 2707
++ ++ G++ + C L V +GA ++ G ++ A+ + +
Sbjct: 944 HLHGLTYGLSQAHHVLC--LCWVFSVLGAYLVVEGLMKLDEVFLVSSAIVLGAMALGQTS 1001
Query: 2706 VIEKDETDYDVEV------------------------EVNGNISFKNVKFSYPTRPDAQV 2599
D T + +GN+ FK V F+YPTRPD V
Sbjct: 1002 SFAPDYTKAMISAAHIFSLLERVPQIDSYSDQGEKPKNCSGNVVFKGVNFNYPTRPDITV 1061
Query: 2598 LKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRV 2419
L+G+ V+ GE +ALVG+SG GKST V LL +Y+ G + +DG+ + ++NI+ +R
Sbjct: 1062 LQGLDISVKQGETLALVGSSGCGKSTTVSLLERFYDPFEGEVLVDGLSVRNLNIQWVRAQ 1121
Query: 2418 IGVVSQEPVLFNTTIEENIRFGNPN--VSLPEIYGALRKANAYDFVCSFPKGIKTIVGER 2245
+G+VSQEP+LF+ +I +NI +G+ N V+ EI A ++AN + F+ S T VG++
Sbjct: 1122 MGIVSQEPILFDCSIGDNIAYGDNNRKVTQEEIETAAKEANIHSFIESLTDKYNTRVGDK 1181
Query: 2244 GTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAH 2065
GTQLSGGQKQRIAIAR L+R PKILLLDEATSALD ESE+VVQ+AL+ A GRT IV+AH
Sbjct: 1182 GTQLSGGQKQRIAIARALIRKPKILLLDEATSALDTESEKVVQEALDKARMGRTCIVIAH 1241
Query: 2064 RLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQL 1936
RLSTI+NA KI V+Q G++VE G H +L+ +GVY LV QL
Sbjct: 1242 RLSTIQNADKIAVIQNGKVVEQGTHQQLLQLKGVYFSLVTIQL 1284
>gi|833699|gb|AAA75000.1| multidrug resistance protein
gi|1098061|prf||2115220A P-glycoprotein
Length = 1287
Score = 771 bits (1991), Expect = 0.0
Identities = 464/1266 (36%), Positives = 705/1266 (55%), Gaps = 51/1266 (4%)
Frame = -1
Query: 3675 EENSNNFSTPLLPQSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMS 3496
+E FS + +KP ++ F +F+ SS +K L L G + SL G P M
Sbjct: 27 KEKKGFFSKFKKKKEKTEKPPKVGVF--TMFRYSSTSDKMLMLFGTIASLAHGAALPLMM 84
Query: 3495 YTFGEVSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQH 3316
FGE++ V + ++ + A E + M +++ G + A +Q
Sbjct: 85 LVFGEMTDSFVNV-GQVDTGNFTWESMINASRELQGQMTTYAYYYSGLGFGVMLCAYIQI 143
Query: 3315 AIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALI 3136
+ ++R + +L+++ +FD G L+T L D++ + E +KIA++
Sbjct: 144 SFWTLSAGRQIKKIRSNFFHAVLRQEIGWFDINDAGELNTRLTDDVSKINEGIGDKIAML 203
Query: 3135 IAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSI 2956
+ +T G + F W+L S + S I + + T K+ YA AG++
Sbjct: 204 LQSLTTLVTGFIIGFIKGWKLTWVMGAISPIMGLSAAIWAKVLSAFTNKELKAYAKAGAV 263
Query: 2955 AFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVV 2776
A + L + +TV + GQ EI RY + L+ +K GI++A+ ++S G + + ++
Sbjct: 264 AEEVLSSIRTVFAFGGQNKEIHRYEKNLEDAKKIGIKKAITANVSIGFAFLMIYAAYSLA 323
Query: 2775 LYVGATMIYSG--------TLETAVVVRDDNVIEKDETDYDVEV---------------- 2668
+ G T+I G T+ AV++ +T ++E
Sbjct: 324 FWYGTTLIIDGGYTIGSVLTVFFAVII---GAFAVGQTSPNIEAFANARGAAYTIFNIID 380
Query: 2667 ----------------EVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASG 2536
++ G+I FKNV F+YP+R D QVLKG++ ++ +G+ +ALVG+SG
Sbjct: 381 NQPKIDSFSKEGLKPDKIKGDIEFKNVIFTYPSRKDIQVLKGLNLNIPSGKTVALVGSSG 440
Query: 2535 SGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRF 2356
GKST VQL+ +Y+ + G I +DG D+ +NI+ LR +IGVVSQEP+LF+TTI +NIR+
Sbjct: 441 CGKSTTVQLIQRFYDPEDGVITLDGQDIRSLNIRYLREIIGVVSQEPILFDTTIADNIRY 500
Query: 2355 GNPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPK 2176
G +V+ EI A ++ANAYDF+ P ++T+VGERGTQLSGGQKQRIAIAR LVRNPK
Sbjct: 501 GREDVTKEEIERATKEANAYDFIMKLPDKLETLVGERGTQLSGGQKQRIAIARALVRNPK 560
Query: 2175 ILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVG 1996
ILLLDEATSALD ESE VVQ AL+ A +GRTTIVVAHRLSTIRNA+ I G IVE G
Sbjct: 561 ILLLDEATSALDTESEAVVQSALDKAREGRTTIVVAHRLSTIRNANAIAGFDNGVIVEQG 620
Query: 1995 NHDELIAKRGVYNDLVQAQLLESHDDHEELPPLAARQLSQELSPLHSYAIQRSTSND--- 1825
+H EL+ + GVY +LV Q +E+ D EE + ++ HS ++R +S +
Sbjct: 621 SHKELMERGGVYFNLVTLQTVETSKDTEEDLETHIYEKKIPVTHTHSNLVRRKSSRNTIK 680
Query: 1824 AGVHDDDMERILDELSK--EGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQ 1651
+ V + + + + +E K EG + +++K +P++ + + V + I G + P A
Sbjct: 681 SKVPETEDKEVDEEEKKKEEGPPPVSFFKVMKLNKPEWPYFVVGVICAMINGATQPAFAI 740
Query: 1650 LIVRTYEGFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKS 1471
+ R FA M S +++L F+ L +T + Q + FGK E L+ RLR+ S
Sbjct: 741 IFSRIIGVFAGPVSQMRSESSMYSLLFLALGGVSFITFFLQGFTFGKAGEILTMRLRLGS 800
Query: 1470 FSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASL 1291
F ML ++DD +S L+ RL TD+S V+ A RL + V + AI + +
Sbjct: 801 FKSMLRQEIGWFDDSKNSTGALTTRLATDASQVQGATGTRLALLAQNVANLGTAIIISFI 860
Query: 1290 YCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNL 1111
Y W++TL +L P ++D E + + + +A+ N+RTV +L
Sbjct: 861 YGWQLTLLILAIVPVIAAAGLVEMKMFAGHAKKDKKELEKAGKISTDAVLNIRTVVSLTR 920
Query: 1110 EDKIMSLISEHLQKIHKSYFKRAIIQGAANGLS----LSCFLFVYSVSFKFGTYLALRKE 943
E K ++ + L+ +++ K+A + G GLS + C +V+SV G YL +
Sbjct: 921 ERKFEAMYEKSLEGPYRNSIKKAHLHGLTYGLSQAHHVLCLCWVFSV---LGAYLVVEGL 977
Query: 942 VAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLF-TYPATMPFSSSDGKK 766
+ + +LV + + A G +++ PDY KA+ +A IF L P +S K
Sbjct: 978 MKLDEVFLVSSAIVLGAMALGQTSSFAPDYTKAMISAAHIFSLLERVPQIDSYSDQGEKP 1037
Query: 765 NIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYH 586
G ++ + V F+Y RPD +L G+++ V G+TLALVG SGCGKST +SLLERFY
Sbjct: 1038 KNCSGNVVFKGVNFNYPTRPDITVLQGLDISVKQGETLALVGSSGCGKSTTVSLLERFYD 1097
Query: 585 AVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYG-LTRSVPQLELEKA 409
+GEV +D +V ++N+ +R+ + +VSQEP LF+CSI +N+ YG R V Q E+E A
Sbjct: 1098 PFEGEVLVDGLSVRNLNIQWVRAQMGIVSQEPILFDCSIGDNIAYGDNNRKVTQEEIETA 1157
Query: 408 LQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDS 229
+ AN +F+ +T VG++G QLSGGQKQRIAIARA++R PK+LLLDEATSALD+
Sbjct: 1158 AKEANIHSFIESLTDKYNTRVGDKGTQLSGGQKQRIAIARALIRKPKILLLDEATSALDT 1217
Query: 228 DSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYW 49
+SEKVVQ ALD A + +V+AHRLST+ NAD IAV++NGKV EQGTH++LL+ + +Y+
Sbjct: 1218 ESEKVVQEALDKARMGRTCIVIAHRLSTIQNADKIAVIQNGKVVEQGTHQQLLQLKGVYF 1277
Query: 48 RLVQKQ 31
LV Q
Sbjct: 1278 SLVTIQ 1283
Score = 313 bits (803), Expect = 1e-83
Identities = 196/590 (33%), Positives = 306/590 (51%), Gaps = 17/590 (2%)
Frame = -1
Query: 1722 DYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIG---------EDMLYYSH------ 1588
D + S G + P++ + + F +G E M+ S
Sbjct: 62 DKMLMLFGTIASLAHGAALPLMMLVFGEMTDSFVNVGQVDTGNFTWESMINASRELQGQM 121
Query: 1587 -LWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSAT 1411
+A + L L Y Q ++ + + ++R F +L ++D + A
Sbjct: 122 TTYAYYYSGLGFGVMLCAYIQISFWTLSAGRQIKKIRSNFFHAVLRQEIGWFDI--NDAG 179
Query: 1410 RLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXX 1231
L+ RL D S + + D++ ++ ++ + + WK+T + P
Sbjct: 180 ELNTRLTDDVSKINEGIGDKIAMLLQSLTTLVTGFIIGFIKGWKLTWVMGAISPIMGLSA 239
Query: 1230 XXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYF 1051
++ A+ + A E L ++RTV A ++K + ++L+ K
Sbjct: 240 AIWAKVLSAFTNKELKAYAKAGAVAEEVLSSIRTVFAFGGQNKEIHRYEKNLEDAKKIGI 299
Query: 1050 KRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAA 871
K+AI + G + YS++F +GT L + V + + A G +
Sbjct: 300 KKAITANVSIGFAFLMIYAAYSLAFWYGTTLIIDGGYTIGSVLTVFFAVIIGAFAVGQTS 359
Query: 870 AYLPDYKKAVHAAGLIFHLF-TYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMI 694
+ + A AA IF++ P FS K + KG+I +NV F Y R D +
Sbjct: 360 PNIEAFANARGAAYTIFNIIDNQPKIDSFSKEGLKPDKIKGDIEFKNVIFTYPSRKDIQV 419
Query: 693 LNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSN 514
L G+NL + GKT+ALVG SGCGKST + L++RFY DG + +D +++ +N+ +LR
Sbjct: 420 LKGLNLNIPSGKTVALVGSSGCGKSTTVQLIQRFYDPEDGVITLDGQDIRSLNIRYLREI 479
Query: 513 LALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERG 334
+ +VSQEP LF+ +I +N+ YG V + E+E+A + ANA++F+ + P L+TLVGERG
Sbjct: 480 IGVVSQEPILFDTTIADNIRYG-REDVTKEEIERATKEANAYDFIMKLPDKLETLVGERG 538
Query: 333 AQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHR 154
QLSGGQKQRIAIARA++RNPK+LLLDEATSALD++SE VVQ+ALD A E +T+VVAHR
Sbjct: 539 TQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQSALDKAREGRTTIVVAHR 598
Query: 153 LSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQVETPSD 4
LST+ NA++IA NG + EQG+H+EL+ + +Y+ LV Q VET D
Sbjct: 599 LSTIRNANAIAGFDNGVIVEQGSHKELMERGGVYFNLVTLQ--TVETSKD 646
Score = 289 bits (739), Expect = 4e-76
Identities = 194/583 (33%), Positives = 299/583 (51%), Gaps = 44/583 (7%)
Frame = -1
Query: 3552 FLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQV 3373
F++GV+ +++ G QP + F + V + + + E M +
Sbjct: 721 FVVGVICAMINGATQPAFAIIFSRIIGVFAGPVSQMRS---------------ESSMYSL 765
Query: 3372 VFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSV--STGHLS 3199
+F G FI LQ G+ T R+R +L+++ +FD STG L+
Sbjct: 766 LF--LALGGVSFITFFLQGFTFGKAGEILTMRLRLGSFKSMLRQEIGWFDDSKNSTGALT 823
Query: 3198 TVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFIN 3019
T L + + + ++AL+ V + ++F W+L + IA +G +
Sbjct: 824 TRLATDASQVQGATGTRLALLAQNVANLGTAIIISFIYGWQLTLLILAIVPVIAAAGLVE 883
Query: 3018 SAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRA 2839
K AG I+ + +TV SL ++ Y + L+ + I++A
Sbjct: 884 MKMFAGHAKKDKKELEKAGKISTDAVLNIRTVVSLTRERKFEAMYEKSLEGPYRNSIKKA 943
Query: 2838 LMYSISRGVT---YFFCNSLNTVVLYVGATMIYSGTLET-------------AVVVRDDN 2707
++ ++ G++ + C L V +GA ++ G ++ A+ + +
Sbjct: 944 HLHGLTYGLSQAHHVLC--LCWVFSVLGAYLVVEGLMKLDEVFLVSSAIVLGAMALGQTS 1001
Query: 2706 VIEKDETDYDVEV------------------------EVNGNISFKNVKFSYPTRPDAQV 2599
D T + +GN+ FK V F+YPTRPD V
Sbjct: 1002 SFAPDYTKAMISAAHIFSLLERVPQIDSYSDQGEKPKNCSGNVVFKGVNFNYPTRPDITV 1061
Query: 2598 LKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRV 2419
L+G+ V+ GE +ALVG+SG GKST V LL +Y+ G + +DG+ + ++NI+ +R
Sbjct: 1062 LQGLDISVKQGETLALVGSSGCGKSTTVSLLERFYDPFEGEVLVDGLSVRNLNIQWVRAQ 1121
Query: 2418 IGVVSQEPVLFNTTIEENIRFGNPN--VSLPEIYGALRKANAYDFVCSFPKGIKTIVGER 2245
+G+VSQEP+LF+ +I +NI +G+ N V+ EI A ++AN + F+ S T VG++
Sbjct: 1122 MGIVSQEPILFDCSIGDNIAYGDNNRKVTQEEIETAAKEANIHSFIESLTDKYNTRVGDK 1181
Query: 2244 GTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAH 2065
GTQLSGGQKQRIAIAR L+R PKILLLDEATSALD ESE+VVQ+AL+ A GRT IV+AH
Sbjct: 1182 GTQLSGGQKQRIAIARALIRKPKILLLDEATSALDTESEKVVQEALDKARMGRTCIVIAH 1241
Query: 2064 RLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQL 1936
RLSTI+NA KI V+Q G++VE G H +L+ +GVY LV QL
Sbjct: 1242 RLSTIQNADKIAVIQNGKVVEQGTHQQLLQLKGVYFSLVTIQL 1284
>gi|45382457|ref|NP_990225.1| ABC transporter protein [Gallus gallus]
gi|3355757|emb|CAA08835.1| ABC transporter protein; P-glycoprotein
[Gallus gallus]
Length = 1288
Score = 770 bits (1988), Expect = 0.0
Identities = 455/1251 (36%), Positives = 689/1251 (54%), Gaps = 53/1251 (4%)
Frame = -1
Query: 3624 KKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAI 3445
KKP + +F+ SSC +K L + G L ++ G P FG+++ VT + +
Sbjct: 40 KKPQMVSPL--ALFRYSSCTDKLLMIFGSLLAIAHGTSLPIAMIIFGDMTDSFVT--SGM 95
Query: 3444 NNKTIDPADLEKA---YEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRV 3274
N T + + L + + + E M + +++ A + A +Q + ++
Sbjct: 96 TNITGNSSGLNSSADVFNKLEEEMTRYAYYYSAIAAAVLVAAYIQTSFWTLAAGRQVKKI 155
Query: 3273 RKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALA 3094
R+++ +++++ +FD G L+T L D++ + E +KI +I T F G +
Sbjct: 156 REKFFHAIMRQEIGWFDVNDAGELNTRLIDDVSKINEGIGDKIGFLIQSETTFLTGFIVG 215
Query: 3093 FYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSL 2914
F W+L + S + S + + + T K+ YA AG++A + L A +TV +
Sbjct: 216 FIRGWKLTLVILAVSPVLGLSAALWAKILTAFTDKEQAAYAKAGAVAEEVLSAVRTVIAF 275
Query: 2913 NGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYSG--- 2743
GQ+ EI+RY + L+ ++ GIR+A+ +IS G + + + + G T+I +
Sbjct: 276 GGQEKEIKRYHKNLEDAKRIGIRKAITSNISMGAAFLLIYASYALAFWYGTTLILANEYS 335
Query: 2742 -----------------------TLETAVVVRDDNVIEKDETDYDVEVE----------- 2665
++E R + D + E++
Sbjct: 336 IGNVLTVFFSVLIGAFSIGQTAPSIEAFANARGAAYAIFNIIDNEPEIDSYSDAGHKPDH 395
Query: 2664 VNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNID 2485
+ GN+ F+NV F+YP+RPD ++LKG++ V G+ +ALVG SG GKST VQL+ +Y+
Sbjct: 396 IKGNLEFQNVFFNYPSRPDVEILKGLNLKVNCGQTVALVGGSGCGKSTTVQLIQRFYDPK 455
Query: 2484 SGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKA 2305
G I IDG DL +N++ LR +IGVV+QEPVLF TTI ENIR+G +V++ EI A ++A
Sbjct: 456 EGTITIDGQDLKSLNVRYLREIIGVVNQEPVLFATTIAENIRYGREDVTMEEIERATKEA 515
Query: 2304 NAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQ 2125
NAYDF+ PK +T+VGERG Q+SGGQKQRIAIAR LV NPKILLLDEATSALD ESE
Sbjct: 516 NAYDFIMKLPKKFETVVGERGAQMSGGQKQRIAIARALVHNPKILLLDEATSALDTESES 575
Query: 2124 VVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQ 1945
VVQ AL+ A +GRTT+VVAHRLST+RNA I V + G I E GNH +LI K+G+Y LV
Sbjct: 576 VVQAALDKAREGRTTVVVAHRLSTVRNADLIAVFESGVITEQGNHSQLIEKKGIYYKLVN 635
Query: 1944 AQLLESHDDHEELPPLAA--------RQLSQEL-SPLHSYAIQRSTSNDAGVHDDDMERI 1792
Q +E+ D E A L + L L + +RS +D D +
Sbjct: 636 MQTIETEDPSSEKSENAVSVKRSGSQSNLDESLKKELRRGSTRRSMKKPGEPNDTDEK-- 693
Query: 1791 LDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIG 1612
E + +++K + ++ + F + + G P + + F+
Sbjct: 694 -GSSPDEELPPVSFLKLMKLNKNEWPYFVAGTFCAIVNGALQPAFSVIFSEIIGIFSETD 752
Query: 1611 EDML-YYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFY 1435
+ +L S+L++L F+ L + T + Q + FGK E L+ +LR +F ML A++
Sbjct: 753 QKVLREKSNLYSLLFLALGIISFFTFFVQGFAFGKAGEILTMKLRFMAFKAMLRQDMAWF 812
Query: 1434 DDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMF 1255
DDP +S L+ RL D+S VK A RL + + + I + +Y W++TL +L
Sbjct: 813 DDPKNSTGALTTRLANDASQVKGATGVRLALIAQNIANLGTGIIISLVYGWQLTLLLLAV 872
Query: 1254 FPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHL 1075
P ++D I E + + A EA+EN+RTV +L E + + EHL
Sbjct: 873 VPIIAVAGMIEMKMLAGHAKKDKIELEAAGKIATEAIENIRTVASLTREKRFELMYGEHL 932
Query: 1074 QKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMT 895
+++ K+A I G LS + F Y+ F+FG YL + + +LV +
Sbjct: 933 LVPYRNSVKKAHIFGFCFSLSQAMMFFTYAGCFRFGAYLVVNGHIEYKTVFLVFSAVVFG 992
Query: 894 ANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEK--GEIIGENVQFH 721
A G +++ PDY KA +A +F LF + DG+K EK G ++V+F+
Sbjct: 993 AMALGQTSSFAPDYAKAKISAAHLFVLFNRVPPIDSYREDGEKP-EKFGGNTRIKDVKFN 1051
Query: 720 YDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVED 541
Y RP+ IL G+NL V+ G+TLALVG SGCGKST++ LLERFY + GE+ D + +
Sbjct: 1052 YPNRPEVKILQGLNLAVEKGETLALVGSSGCGKSTVVQLLERFYDPLSGEIVFDDIDAKT 1111
Query: 540 INLNHLRSNLALVSQEPTLFNCSIRENLLYG-LTRSVPQLELEKALQTANAFNFVFQFPQ 364
+N+ LRS++ +VSQEP LF+ +I EN+ YG +R V E+ A + A+ +F+ P+
Sbjct: 1112 LNIQWLRSHIGIVSQEPILFDFTIAENIAYGDNSREVSHEEIISAAKAASIHSFIDSLPE 1171
Query: 363 GLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASE 184
+T VG++G QLSGGQKQRIAIARA++R P++LLLDEATSALD++SEK+VQ ALD A E
Sbjct: 1172 KYNTRVGDKGTQLSGGQKQRIAIARALIRKPQILLLDEATSALDTESEKIVQEALDKARE 1231
Query: 183 RLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
+ +V+AHRLST+ NAD IAV++NGKV EQGTH++LL ++ Y+ LV Q
Sbjct: 1232 GRTCIVIAHRLSTIQNADKIAVIQNGKVIEQGTHQQLLAEKGFYYSLVNVQ 1282
Score = 332 bits (851), Expect = 4e-89
Identities = 196/541 (36%), Positives = 306/541 (56%), Gaps = 1/541 (0%)
Frame = -1
Query: 1626 FAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLP 1447
F + E+M Y++ ++ +A + Y Q ++ + + ++R K F ++
Sbjct: 112 FNKLEEEMTRYAYYYSA----IAAAVLVAAYIQTSFWTLAAGRQVKKIREKFFHAIMRQE 167
Query: 1446 CAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLE 1267
++D + A L+ RL D S + + D++G +I + + WK+TL
Sbjct: 168 IGWFDV--NDAGELNTRLIDDVSKINEGIGDKIGFLIQSETTFLTGFIVGFIRGWKLTLV 225
Query: 1266 VLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLI 1087
+L P ++ A+ + A E L VRTV A ++K +
Sbjct: 226 ILAVSPVLGLSAALWAKILTAFTDKEQAAYAKAGAVAEEVLSAVRTVIAFGGQEKEIKRY 285
Query: 1086 SEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMT 907
++L+ + ++AI + G + Y+++F +GT L L E + + V +
Sbjct: 286 HKNLEDAKRIGIRKAITSNISMGAAFLLIYASYALAFWYGTTLILANEYSIGNVLTVFFS 345
Query: 906 LSMTANMAGSAAAYLPDYKKAVHAAGLIFHLF-TYPATMPFSSSDGKKNIEKGEIIGENV 730
+ + A G A + + A AA IF++ P +S + K + KG + +NV
Sbjct: 346 VLIGAFSIGQTAPSIEAFANARGAAYAIFNIIDNEPEIDSYSDAGHKPDHIKGNLEFQNV 405
Query: 729 QFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSEN 550
F+Y RPD IL G+NLKV+ G+T+ALVG SGCGKST + L++RFY +G + ID ++
Sbjct: 406 FFNYPSRPDVEILKGLNLKVNCGQTVALVGGSGCGKSTTVQLIQRFYDPKEGTITIDGQD 465
Query: 549 VEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQF 370
++ +N+ +LR + +V+QEP LF +I EN+ YG V E+E+A + ANA++F+ +
Sbjct: 466 LKSLNVRYLREIIGVVNQEPVLFATTIAENIRYG-REDVTMEEIERATKEANAYDFIMKL 524
Query: 369 PQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTA 190
P+ +T+VGERGAQ+SGGQKQRIAIARA++ NPK+LLLDEATSALD++SE VVQ ALD A
Sbjct: 525 PKKFETVVGERGAQMSGGQKQRIAIARALVHNPKILLLDEATSALDTESESVVQAALDKA 584
Query: 189 SERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQVETP 10
E +TVVVAHRLSTV NAD IAV ++G + EQG H +L+ K+ IY++LV Q I+ E P
Sbjct: 585 REGRTTVVVAHRLSTVRNADLIAVFESGVITEQGNHSQLIEKKGIYYKLVNMQTIETEDP 644
Query: 9 S 7
S
Sbjct: 645 S 645
>gi|72477|pir||DVHY1C multidrug resistance protein 1 - Chinese hamster
gi|191155|gb|AAA37004.1| p-glycoprotein
Length = 1276
Score = 770 bits (1987), Expect = 0.0
Identities = 458/1254 (36%), Positives = 689/1254 (54%), Gaps = 55/1254 (4%)
Frame = -1
Query: 3627 EKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTI--- 3457
EKK + + +F+ + ++ L+G L +++ G P M FG+++ ++
Sbjct: 25 EKKEKKPVVSVFTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLVFGDMTDSFASVGNI 84
Query: 3456 -TNAINNKT-IDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTT 3283
TNA NN T ++ +D+ + + E M +++ G I A +Q +
Sbjct: 85 PTNATNNATQVNASDI---FGKLEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQI 141
Query: 3282 YRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGT 3103
+++R+++ ++ ++ +FD G L+T L D++ + E +KI + + F G
Sbjct: 142 HKIRQKFFHAIMNQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGF 201
Query: 3102 ALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTV 2923
+ F W+L + S + S I + + T K+ YA AG++A + L A +TV
Sbjct: 202 IIGFTRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELQAYAKAGAVAEEVLAAIRTV 261
Query: 2922 CSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYSG 2743
+ GQK E+ERY L+ ++ GI++A+ +IS G + + + + G +++ S
Sbjct: 262 IAFGGQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISK 321
Query: 2742 --------TLETAVVVRDD-----------------------NVIEK-------DETDYD 2677
T+ AV++ N+I+ + Y
Sbjct: 322 EYSIGQVLTVFFAVLIAPFSIGQASPNIEAFANARGAAYEIFNIIDNKPSIDSFSKNGYK 381
Query: 2676 VEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHY 2497
+ + GN+ FKN+ FSYP+R D Q+LKG++ VQ+G+ +ALVG SG GKST VQLL
Sbjct: 382 PD-NIKGNLEFKNIHFSYPSRKDVQILKGLNLKVQSGQTVALVGNSGCGKSTTVQLLQRL 440
Query: 2496 YNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGA 2317
Y+ G + IDG D+ +N++ LR +IGVVSQEPVLF TTI ENIR+G NV++ EI A
Sbjct: 441 YDPTEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKA 500
Query: 2316 LRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDN 2137
+++ANAYDF+ P T+VGERG QLSGGQKQRIAIAR LVRNPKILLLDEATSALD
Sbjct: 501 VKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDT 560
Query: 2136 ESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYN 1957
ESE VVQ AL+ A +GRTTIV+AHRLST+RNA I G IVE GNH+EL+ ++G+Y
Sbjct: 561 ESEAVVQAALDKAREGRTTIVIAHRLSTVRNADIIAGFDGGVIVEQGNHEELMREKGIYF 620
Query: 1956 DLVQAQLL--------ESHDDHEELPPLAARQLSQELSPLHSYAIQRSTSNDAGVHDDDM 1801
LV Q E + E+ L S + + +RS G HD D
Sbjct: 621 KLVMTQTAGNEIELGNEVGESKNEIDNLDMSSKDSASSLIRRRSTRRSI---RGPHDQDR 677
Query: 1800 ERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFA 1621
+ E E + I+K ++ + + +F + + G P + + + F
Sbjct: 678 KLSTKEALDEDVPPISFWRILKLNSSEWPYFVVGIFCAIVNGALQPAFSIIFSKVVGVFT 737
Query: 1620 MIGED--MLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLP 1447
+D + S+L++L F+ L V +T + Q + FGK E L+ RLR F ML
Sbjct: 738 RNTDDETKRHDSNLFSLLFLILGVISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQD 797
Query: 1446 CAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLE 1267
+++D+P ++ L+ RL D+ VK A RL + + + I + +Y W++TL
Sbjct: 798 VSWFDNPKNTTGALTTRLANDAGQVKGATGARLAVITQNIANLGTGIIISLIYGWQLTLL 857
Query: 1266 VLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLI 1087
+L P +D E S + A EA+EN RTV +L E K ++
Sbjct: 858 LLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFENMY 917
Query: 1086 SEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMT 907
++ LQ +++ K+A + G + + F Y+ F+FG YL R+ + + LV
Sbjct: 918 AQSLQIPYRNALKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVARELMTFENVLLVFSA 977
Query: 906 LSMTANMAGSAAAYLPDYKKA-VHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGENV 730
+ A G +++ PDY KA V A+ +I + P+ +S+ K N +G + V
Sbjct: 978 IVFGAMAVGQVSSFAPDYAKAKVSASHIIMIIEKVPSIDSYSTGGLKPNTLEGNVKFNEV 1037
Query: 729 QFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSEN 550
F+Y RPD +L G+NL+V G+TLALVG SGCGKST++ LLERFY + G V +D +
Sbjct: 1038 VFNYPTRPDIPVLQGLNLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKE 1097
Query: 549 VEDINLNHLRSNLALVSQEPTLFNCSIRENLLYG-LTRSVPQLELEKALQTANAFNFVFQ 373
V +N+ LR++L +VSQEP LF+CSI EN+ YG +R V Q E+E+A + AN F+
Sbjct: 1098 VNQLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIERAAKEANIHQFIES 1157
Query: 372 FPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDT 193
P +T VG++G QLSGGQKQRIAIARA++R P +LLLDEATSALD++SEKVVQ ALD
Sbjct: 1158 LPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDK 1217
Query: 192 ASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
A E + +V+AHRLST+ NAD I V++NGKV E GTH++LL ++ IY+ +V Q
Sbjct: 1218 AREGRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQ 1271
>gi|126924|sp|P21448|MDR1_CRIGR Multidrug resistance protein 1
(P-glycoprotein 1)
gi|191165|gb|AAA68883.1| p-glycoprotein isoform I
Length = 1276
Score = 769 bits (1986), Expect = 0.0
Identities = 458/1254 (36%), Positives = 689/1254 (54%), Gaps = 55/1254 (4%)
Frame = -1
Query: 3627 EKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTI--- 3457
EKK + + +F+ + ++ L+G L +++ G P M FG+++ ++
Sbjct: 25 EKKEKKPVVSVFTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLVFGDMTDSFASVGNI 84
Query: 3456 -TNAINNKT-IDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTT 3283
TNA NN T ++ +D+ + + E M +++ G I A +Q +
Sbjct: 85 PTNATNNATQVNASDI---FGKLEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQI 141
Query: 3282 YRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGT 3103
+++R+++ ++ ++ +FD G L+T L D++ + E +KI + + F G
Sbjct: 142 HKIRQKFFHAIMNQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGF 201
Query: 3102 ALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTV 2923
+ F W+L + S + S I + + T K+ YA AG++A + L A +TV
Sbjct: 202 IIGFTRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELQAYAKAGAVAEEVLAAIRTV 261
Query: 2922 CSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYSG 2743
+ GQK E+ERY L+ ++ GI++A+ +IS G + + + + G +++ S
Sbjct: 262 IAFGGQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISK 321
Query: 2742 --------TLETAVVV-----------------------RDDNVIEK-------DETDYD 2677
T+ AV++ N+I+ + Y
Sbjct: 322 EYSIGQVLTVFFAVLIGAFSIGQASPNIEAFANARGAAYEIFNIIDNKPSIDSFSKNGYK 381
Query: 2676 VEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHY 2497
+ + GN+ FKN+ FSYP+R D Q+LKG++ VQ+G+ +ALVG SG GKST VQLL
Sbjct: 382 PD-NIKGNLEFKNIHFSYPSRKDVQILKGLNLKVQSGQTVALVGNSGCGKSTTVQLLQRL 440
Query: 2496 YNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGA 2317
Y+ G + IDG D+ +N++ LR +IGVVSQEPVLF TTI ENIR+G NV++ EI A
Sbjct: 441 YDPTEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKA 500
Query: 2316 LRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDN 2137
+++ANAYDF+ P T+VGERG QLSGGQKQRIAIAR LVRNPKILLLDEATSALD
Sbjct: 501 VKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDT 560
Query: 2136 ESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYN 1957
ESE VVQ AL+ A +GRTTIV+AHRLST+RNA I G IVE GNH+EL+ ++G+Y
Sbjct: 561 ESEAVVQAALDKAREGRTTIVIAHRLSTVRNADIIAGFDGGVIVEQGNHEELMREKGIYF 620
Query: 1956 DLVQAQLL--------ESHDDHEELPPLAARQLSQELSPLHSYAIQRSTSNDAGVHDDDM 1801
LV Q E + E+ L S + + +RS G HD D
Sbjct: 621 KLVMTQTAGNEIELGNEVGESKNEIDNLDMSSKDSASSLIRRRSTRRSI---RGPHDQDR 677
Query: 1800 ERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFA 1621
+ E E + I+K ++ + + +F + + G P + + + F
Sbjct: 678 KLSTKEALDEDVPPISFWRILKLNSSEWPYFVVGIFCAIVNGALQPAFSIIFSKVVGVFT 737
Query: 1620 MIGED--MLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLP 1447
+D + S+L++L F+ L V +T + Q + FGK E L+ RLR F ML
Sbjct: 738 RNTDDETKRHDSNLFSLLFLILGVISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQD 797
Query: 1446 CAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLE 1267
+++D+P ++ L+ RL D+ VK A RL + + + I + +Y W++TL
Sbjct: 798 VSWFDNPKNTTGALTTRLANDAGQVKGATGARLAVITQNIANLGTGIIISLIYGWQLTLL 857
Query: 1266 VLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLI 1087
+L P +D E S + A EA+EN RTV +L E K ++
Sbjct: 858 LLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFENMY 917
Query: 1086 SEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMT 907
++ LQ +++ K+A + G + + F Y+ F+FG YL R+ + + LV
Sbjct: 918 AQSLQIPYRNALKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVARELMTFENVLLVFSA 977
Query: 906 LSMTANMAGSAAAYLPDYKKA-VHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGENV 730
+ A G +++ PDY KA V A+ +I + P+ +S+ K N +G + V
Sbjct: 978 IVFGAMAVGQVSSFAPDYAKAKVSASHIIMIIEKVPSIDSYSTGGLKPNTLEGNVKFNEV 1037
Query: 729 QFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSEN 550
F+Y RPD +L G+NL+V G+TLALVG SGCGKST++ LLERFY + G V +D +
Sbjct: 1038 VFNYPTRPDIPVLQGLNLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKE 1097
Query: 549 VEDINLNHLRSNLALVSQEPTLFNCSIRENLLYG-LTRSVPQLELEKALQTANAFNFVFQ 373
V +N+ LR++L +VSQEP LF+CSI EN+ YG +R V Q E+E+A + AN F+
Sbjct: 1098 VNQLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIERAAKEANIHQFIES 1157
Query: 372 FPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDT 193
P +T VG++G QLSGGQKQRIAIARA++R P +LLLDEATSALD++SEKVVQ ALD
Sbjct: 1158 LPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDK 1217
Query: 192 ASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
A E + +V+AHRLST+ NAD I V++NGKV E GTH++LL ++ IY+ +V Q
Sbjct: 1218 AREGRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQ 1271
>gi|40644181|emb|CAC86600.1| multidrug resistance protein [Platichthys
flesus]
Length = 1292
Score = 768 bits (1982), Expect = 0.0
Identities = 448/1238 (36%), Positives = 690/1238 (55%), Gaps = 52/1238 (4%)
Frame = -1
Query: 3588 VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNA--INNKTIDPADL 3415
VF+ + + F+ L G + ++ G P M FG+++ LV +N T+ +
Sbjct: 49 VFRFADSLDIFMILCGTVMAMANGVVLPLMCIVFGDMTDSLVNFPTGEISDNFTVIYPNF 108
Query: 3414 E--KAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKK 3241
+ MN+ ++ + G + A LQ ++ R+RK + R++++
Sbjct: 109 TGLPINSTLQEDMNRYAIYYSIMGATVLVAAYLQVSLWTMAAGRQVKRIRKLFFHRIMQQ 168
Query: 3240 DAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYG 3061
D +FD TG L+T L D++ + +E +K A++I T F + F W+L
Sbjct: 169 DIGWFDVNETGELNTRLIDDVYKIQEGIGDKAAMLIQAYTTFLSAFVIGFTKGWKLTLVI 228
Query: 3060 IFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYT 2881
+ S + S + S + T K+ YA AG++A + L A +TV + +GQ EI+RY
Sbjct: 229 LAVSPALGLSAALFSKVLTSFTSKEQAAYAKAGAVAEEVLAAIRTVFAFSGQDREIKRYH 288
Query: 2880 EELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYS-----GTLETAVVVR 2716
+ L+ + GI++AL +IS G T+ + + G+T+I S G++ T + V
Sbjct: 289 KNLEDAKIMGIKKALSANISMGFTFMVIYLSYALAFWYGSTLILSNEYTIGSVLTVLFVV 348
Query: 2715 DDNVIEKDETDYDVEV--------------------------------EVNGNISFKNVK 2632
++ +++ + GNI FKN+
Sbjct: 349 LIGAFTMGQSSANIQTFASARGAAHKVYSIIDNNPTIDSYSEAGFKPDSIKGNIEFKNIH 408
Query: 2631 FSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDL 2452
FSYPTRPD Q+LK +S V++G+ +ALVG+SG GKST VQLL +Y+ G +F+DG D+
Sbjct: 409 FSYPTRPDVQILKNMSLSVKSGQTMALVGSSGCGKSTTVQLLQRFYDPQDGAVFVDGHDI 468
Query: 2451 NDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPK 2272
+N++ LR +IGVVSQEP+LF TTI ENIR+G +V+ EI A ++ANAYDF+ P
Sbjct: 469 RSLNVRYLREMIGVVSQEPILFATTISENIRYGRLDVTDQEIEQAAKEANAYDFIIKLPD 528
Query: 2271 GIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQ 2092
+T+VG+RGTQ+SGGQKQR+AIAR LVRNPKILLLDEATSALD ESE +VQ AL+
Sbjct: 529 KFETLVGDRGTQMSGGQKQRVAIARALVRNPKILLLDEATSALDAESETIVQAALDKVRL 588
Query: 2091 GRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLL----ESH 1924
GRTTIVVAHRLSTIRNA I Q G++ EVG H +L+ K+G+Y LV Q E+
Sbjct: 589 GRTTIVVAHRLSTIRNADVIAGFQDGQVAEVGTHSQLMEKKGIYQRLVTTQTFQDVEEAK 648
Query: 1923 DDHEELPPLAARQLSQELSPLHSYAIQRSTSNDAGVHDDDMERILDELSK----EGAKKS 1756
+ EEL L+ LS Y + + + + E+ + + E
Sbjct: 649 EAEEELSVDEKSPLADSLSECTPYRRKTTRGSSMSASEGGKEKTESDKDETEEDENVPPV 708
Query: 1755 NLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDML-YYSHLWA 1579
+ ++++ P++ ++ + + I G P+ A + + FA ++++ + L++
Sbjct: 709 SFLKVLRLNLPEWPYMLVGTVCAIINGAMQPVFAIIFSKIITVFAEKDQELVRQRATLFS 768
Query: 1578 LSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSN 1399
L F + +T++ Q + FGK E L+ +LR+ +F M+ +++D+P +S L+
Sbjct: 769 LMFAVIGGVSFVTMFLQGFCFGKSGEILTLKLRLGAFKAMMRQDLSWFDNPKNSVGALTT 828
Query: 1398 RLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXX 1219
RL TD++ V+ A R+ + + ++ + +Y W++TL +L P
Sbjct: 829 RLATDAAQVQGATGVRMATLAQNFANLGTSVIISFIYGWELTLLILAVVPAMVLAGAVEM 888
Query: 1218 XXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAI 1039
ED E + + + EA+EN+RTV +L E K SL ++L+ +K+ K+A
Sbjct: 889 KLLTGHAVEDKKELEKAGKISTEAIENIRTVASLTREPKFESLYHKNLEVPYKNSTKKAH 948
Query: 1038 IQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLP 859
+ GA S + F Y+ F+FG +L + +LV+ + A G A ++ P
Sbjct: 949 VYGATFAFSQAMIYFAYAGCFRFGAWLIEEGRMDVQGVFLVISAVLYGAMAIGEANSFAP 1008
Query: 858 DYKKAVHAAGLIFHLFTYPATMPFSSSDGK-KNIEKGEIIGENVQFHYDQRPDRMILNGV 682
+Y KA +A + L + S +G+ + G + ENV+F+Y RP+ +L G+
Sbjct: 1009 NYAKAKMSASHLMMLMNLEPAIDNLSQEGETPDRFDGNVHFENVRFNYPSRPNLPVLQGL 1068
Query: 681 NLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALV 502
+L+V G+TLALVG SGCGKSTII LLERFY +G V +D+ N + +N++ LRS + +V
Sbjct: 1069 DLEVKRGETLALVGSSGCGKSTIIQLLERFYDPREGSVVLDNVNTKQLNIHWLRSQMGIV 1128
Query: 501 SQEPTLFNCSIRENLLYGLTRSVPQL-ELEKALQTANAFNFVFQFPQGLDTLVGERGAQL 325
SQEPTLF+C++ +N+ YG + + E+ A + AN +F+ + P+ DT G++G QL
Sbjct: 1129 SQEPTLFDCTLAQNIAYGDNSRIATMDEIVAAAKAANIHSFIQELPEKYDTQAGDKGTQL 1188
Query: 324 SGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLST 145
SGGQKQRIAIARAILRNP +LLLDEATSALD++SEKVVQ ALD AS+ + ++VAHRLST
Sbjct: 1189 SGGQKQRIAIARAILRNPMLLLLDEATSALDTESEKVVQEALDQASKGRTCIIVAHRLST 1248
Query: 144 VVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
+ NAD IAVL+ G V EQGTH++LL KR +Y LV Q
Sbjct: 1249 IQNADRIAVLQGGVVVEQGTHQQLLAKRGVYHMLVTTQ 1286
Score = 305 bits (782), Expect = 4e-81
Identities = 187/531 (35%), Positives = 283/531 (53%), Gaps = 1/531 (0%)
Frame = -1
Query: 1611 EDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYD 1432
EDM Y A+ + + + Y Q + + + R+R K F H + +
Sbjct: 119 EDMNRY----AIYYSIMGATVLVAAYLQVSLWTMAAGRQVKRIR-KLFFHRIMQQDIGWF 173
Query: 1431 DPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFF 1252
D N + L+ RL D ++ + D+ +I A WK+TL +L
Sbjct: 174 DVNETG-ELNTRLIDDVYKIQEGIGDKAAMLIQAYTTFLSAFVIGFTKGWKLTLVILAVS 232
Query: 1251 PXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQ 1072
P ++ A+ + A E L +RTV A + +D+ + ++L+
Sbjct: 233 PALGLSAALFSKVLTSFTSKEQAAYAKAGAVAEEVLAAIRTVFAFSGQDREIKRYHKNLE 292
Query: 1071 KIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTA 892
K+A+ + G + Y+++F +G+ L L E VL + + A
Sbjct: 293 DAKIMGIKKALSANISMGFTFMVIYLSYALAFWYGSTLILSNEYTIGSVLTVLFVVLIGA 352
Query: 891 NMAGSAAAYLPDYKKAVHAAGLIFHLF-TYPATMPFSSSDGKKNIEKGEIIGENVQFHYD 715
G ++A + + A AA ++ + P +S + K + KG I +N+ F Y
Sbjct: 353 FTMGQSSANIQTFASARGAAHKVYSIIDNNPTIDSYSEAGFKPDSIKGNIEFKNIHFSYP 412
Query: 714 QRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDIN 535
RPD IL ++L V G+T+ALVG SGCGKST + LL+RFY DG V +D ++ +N
Sbjct: 413 TRPDVQILKNMSLSVKSGQTMALVGSSGCGKSTTVQLLQRFYDPQDGAVFVDGHDIRSLN 472
Query: 534 LNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLD 355
+ +LR + +VSQEP LF +I EN+ YG V E+E+A + ANA++F+ + P +
Sbjct: 473 VRYLREMIGVVSQEPILFATTISENIRYGRL-DVTDQEIEQAAKEANAYDFIIKLPDKFE 531
Query: 354 TLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLS 175
TLVG+RG Q+SGGQKQR+AIARA++RNPK+LLLDEATSALD++SE +VQ ALD +
Sbjct: 532 TLVGDRGTQMSGGQKQRVAIARALVRNPKILLLDEATSALDAESETIVQAALDKVRLGRT 591
Query: 174 TVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQ 22
T+VVAHRLST+ NAD IA ++G+VAE GTH +L+ K+ IY RLV Q Q
Sbjct: 592 TIVVAHRLSTIRNADVIAGFQDGQVAEVGTHSQLMEKKGIYQRLVTTQTFQ 642
Score = 282 bits (721), Expect = 5e-74
Identities = 182/579 (31%), Positives = 296/579 (50%), Gaps = 41/579 (7%)
Frame = -1
Query: 3549 LLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQVV 3370
L+G + +++ G QP + F ++ V EK E +
Sbjct: 725 LVGTVCAIINGAMQPVFAIIFSKIITVFA----------------EKDQELVRQRATLFS 768
Query: 3369 FHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSV--STGHLST 3196
F + G F+ LQ G+ T ++R ++++D +FD+ S G L+T
Sbjct: 769 LMFAVIGGVSFVTMFLQGFCFGKSGEILTLKLRLGAFKAMMRQDLSWFDNPKNSVGALTT 828
Query: 3195 VLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINS 3016
L + + + ++A + + ++F W L + + +G +
Sbjct: 829 RLATDAAQVQGATGVRMATLAQNFANLGTSVIISFIYGWELTLLILAVVPAMVLAGAVEM 888
Query: 3015 AGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRAL 2836
+ + AG I+ + + +TV SL + Y + L+ K ++A
Sbjct: 889 KLLTGHAVEDKKELEKAGKISTEAIENIRTVASLTREPKFESLYHKNLEVPYKNSTKKAH 948
Query: 2835 MY----SISRGVTYFF---CNSLNTVVL------YVGATMIYSGTLETAVVVRDDN---- 2707
+Y + S+ + YF C ++ G ++ S L A+ + + N
Sbjct: 949 VYGATFAFSQAMIYFAYAGCFRFGAWLIEEGRMDVQGVFLVISAVLYGAMAIGEANSFAP 1008
Query: 2706 --------------------VIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGI 2587
I+ + + +GN+ F+NV+F+YP+RP+ VL+G+
Sbjct: 1009 NYAKAKMSASHLMMLMNLEPAIDNLSQEGETPDRFDGNVHFENVRFNYPSRPNLPVLQGL 1068
Query: 2586 SFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVV 2407
+V+ GE +ALVG+SG GKST++QLL +Y+ G++ +D ++ +NI LR +G+V
Sbjct: 1069 DLEVKRGETLALVGSSGCGKSTIIQLLERFYDPREGSVVLDNVNTKQLNIHWLRSQMGIV 1128
Query: 2406 SQEPVLFNTTIEENIRFGNPN--VSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQL 2233
SQEP LF+ T+ +NI +G+ + ++ EI A + AN + F+ P+ T G++GTQL
Sbjct: 1129 SQEPTLFDCTLAQNIAYGDNSRIATMDEIVAAAKAANIHSFIQELPEKYDTQAGDKGTQL 1188
Query: 2232 SGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLST 2053
SGGQKQRIAIAR ++RNP +LLLDEATSALD ESE+VVQ+AL+ AS+GRT I+VAHRLST
Sbjct: 1189 SGGQKQRIAIARAILRNPMLLLLDEATSALDTESEKVVQEALDQASKGRTCIIVAHRLST 1248
Query: 2052 IRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQL 1936
I+NA +I V+Q G +VE G H +L+AKRGVY+ LV Q+
Sbjct: 1249 IQNADRIAVLQGGVVVEQGTHQQLLAKRGVYHMLVTTQM 1287
>gi|25453402|ref|NP_596892.1| ATP-binding cassette, sub-family B
(MDR/TAP), member 1A; multiple drug resistant 1a [Rattus
norvegicus]
gi|34853968|ref|XP_346684.1| hypothetical protein XP_346683 [Rattus
norvegicus]
gi|7739773|gb|AAF69007.1| multidrug resistance protein 1a [Rattus
norvegicus]
Length = 1272
Score = 766 bits (1979), Expect = 0.0
Identities = 453/1267 (35%), Positives = 688/1267 (53%), Gaps = 51/1267 (4%)
Frame = -1
Query: 3678 MEENSN-----NFSTPLLPQSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGF 3514
+EE+ N NFS EKK + + +F+ + ++F LLG L +++ G
Sbjct: 3 LEEDLNGRADKNFSKMGKKSKKEKKEKKPAVSVLTMFRYAGWLDRFYMLLGTLAAIIHGI 62
Query: 3513 CQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFI 3334
P M FG+++ + N NN+++ + Y + E M +++ G I
Sbjct: 63 ALPLMMLVFGDMTD---SFANVGNNRSMSFYNATDIYAKLEDEMTTYAYYYTGIGAGVLI 119
Query: 3333 FASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFN 3154
A +Q ++ +++R+++ ++ ++ +FD G L+T L D++ + E
Sbjct: 120 VAYIQVSLWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVGELNTRLTDDVSKINEGIG 179
Query: 3153 EKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHY 2974
+KI + + F G + F W+L + S + S I + + T K+ Y
Sbjct: 180 DKIGMFFQAMATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELQAY 239
Query: 2973 ANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCN 2794
A AG++A + L A +TV + GQK E+ERY L+ ++ GI++A+ +IS G +
Sbjct: 240 AKAGAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIY 299
Query: 2793 SLNTVVLYVGATMIYS-------------------------------------GTLETAV 2725
+ + + G +++ S E
Sbjct: 300 ASYALAFWYGTSLVISKEYTIGQVLTVFFSVLIGAFSVGQASPNIEAFANARGAAYEVFS 359
Query: 2724 VVRDDNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVG 2545
++ + I+ + GN+ FKN+ FSYP+R D Q+LKG++ V++G+ +ALVG
Sbjct: 360 IIDNKPSIDSFSKSGHKPDNIQGNLEFKNIHFSYPSRKDVQILKGLNLKVKSGQTVALVG 419
Query: 2544 ASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEEN 2365
SG GKST VQLL Y+ G + IDG D+ +N++ LR +IGVVSQEPVLF TTI EN
Sbjct: 420 NSGCGKSTTVQLLQRLYDPIEGEVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAEN 479
Query: 2364 IRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVR 2185
IR+G NV++ EI A+++ANAYDF+ P T+VGERG QLSGGQKQRIAIAR LVR
Sbjct: 480 IRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVR 539
Query: 2184 NPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIV 2005
NPKILLLDEATSALD ESE VVQ AL+ A +GRTTIV+AHRLST+RNA I G IV
Sbjct: 540 NPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIV 599
Query: 2004 EVGNHDELIAKRGVYNDLVQAQLLES-----HDDHEELPPLAARQLSQELSPLHSYAIQR 1840
E GNHDEL+ ++G+Y LV Q + ++ E + +S + S +
Sbjct: 600 EQGNHDELMREKGIYFKLVMTQTAGNEIELGNEACESKDGIDNVDMSSKDSGSSLIRRRS 659
Query: 1839 STSNDAGVHDDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPI 1660
+ + G HD D E E + ++ I+K ++ + + VF + I G P
Sbjct: 660 TRKSIRGPHDQDGELSTKEALDDDVPPASFWRILKLNSTEWPYFVVGVFCAIINGGLQPA 719
Query: 1659 LAQLIVRTYEGFAM--IGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTR 1486
+ + + F E S+L++L F+ L + +T + Q + FGK E L+ R
Sbjct: 720 FSIIFSKVVGVFTKNDTPEIQRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKR 779
Query: 1485 LRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAI 1306
LR F ML +++DDP ++ L+ RL D++ VK A RL + + + I
Sbjct: 780 LRYMVFKSMLRQDISWFDDPKNTTGALTTRLANDAAQVKGATGSRLAVITQNIANLGTGI 839
Query: 1305 TTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTV 1126
+ +Y W++TL +L P +D E S + A EA+EN RTV
Sbjct: 840 IISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTV 899
Query: 1125 RALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRK 946
+L E K ++ ++ LQ +++ K+A + G + + F Y+ F+FG YL R+
Sbjct: 900 VSLTREQKFETMYAQSLQIPYRNALKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVARE 959
Query: 945 EVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKA-VHAAGLIFHLFTYPATMPFSSSDGK 769
+ + LV + A G +++ PDY KA V A+ +I + P +S+ K
Sbjct: 960 LMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKAKVSASHIIRIIEKIPEIDSYSTEGLK 1019
Query: 768 KNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFY 589
N+ +G + V F+Y RP+ +L G++L+V G+TLALVG SGCGKST++ LLERFY
Sbjct: 1020 PNMLEGNVKFNGVMFNYPTRPNIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFY 1079
Query: 588 HAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYG-LTRSVPQLELEK 412
+ G V +D + ++ +N+ LR++L +VSQEP LF+CSI EN+ YG +R V E+ K
Sbjct: 1080 DPMAGTVFLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSHEEIVK 1139
Query: 411 ALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALD 232
A + AN F+ P+ +T VG++G QLSGGQKQRIAIARA++R P +LLLDEATSALD
Sbjct: 1140 AAKEANIHQFIDSLPEKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALD 1199
Query: 231 SDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIY 52
++SEKVVQ ALD A E + +V+AHRLST+ NAD I V++NG+V E GTH++LL ++ IY
Sbjct: 1200 TESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGQVKEHGTHQQLLAQKGIY 1259
Query: 51 WRLVQKQ 31
+ +V Q
Sbjct: 1260 FSMVSVQ 1266
>gi|39595370|emb|CAE60408.1| Hypothetical protein CBG04013
[Caenorhabditis briggsae]
Length = 1265
Score = 766 bits (1979), Expect = 0.0
Identities = 450/1255 (35%), Positives = 697/1255 (54%), Gaps = 47/1255 (3%)
Frame = -1
Query: 3648 PLLPQSDEKKPSQICSFIRV----VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGE 3481
PLL +S S S +++ +F + + L ++G + +++ G P ++ G
Sbjct: 14 PLLKRSHSSDSSIDESTVKLTNYGLFSYTRGKDLILLIVGTIAAVIHGAGFPLLAIVLGG 73
Query: 3480 VSQVLVTITNA---INNKTIDPADLEK-AYEEYERGMNQVVFHFFLCGCAYFIFASLQHA 3313
++ V + N+ + ++P LE + +E+ + + ++ + G A F+ + +Q A
Sbjct: 74 MTTVFLRAQNSDFVVGVGNVNPNGLEPISIDEFNSEVVKYCIYYLILGVAMFVTSYVQIA 133
Query: 3312 IMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALII 3133
+ +N +++R+ Y+ +L++ Q+FD TG+L+ L D+LER RE +K AL++
Sbjct: 134 CFESYAENLVHKLRQNYLKAILRQQIQWFDKQQTGNLTARLTDDLERVREGLGDKFALLV 193
Query: 3132 AFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIA 2953
F G + F+ W + + F+ I SG S + T + YA AG+IA
Sbjct: 194 QMFAAFLAGYGVGFFYSWSMTLVMMGFAPLIVLSGAKMSKSMATRTKVEQETYAVAGAIA 253
Query: 2952 FQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVL 2773
+T + +TV SLNG K E++R+ L+ G K GI + I G + S +
Sbjct: 254 EETFSSIRTVHSLNGHKRELDRFWNALENGRKTGIVKYCYMGIGVGFSNLCMYSSYALAF 313
Query: 2772 YVGATMIYS---------------------------------GTLETAV-----VVRDDN 2707
+ G+T+I + GT A V+
Sbjct: 314 WYGSTLIINDPTFDRGLIFTVFFAVLSGSTSLGGALPHLASFGTARGAAYTVLRVINSHP 373
Query: 2706 VIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGK 2527
I+ + + + G+ISF+NV F YP+R D VLKGIS +V++GE IALVG+SG GK
Sbjct: 374 KIDPYSLEGLLVDNMKGDISFQNVHFRYPSRKDIPVLKGISLEVKSGEKIALVGSSGCGK 433
Query: 2526 STVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNP 2347
ST+V LL +Y+ G + IDG+DL ++N+ LR IG+VSQEPVLF+ TI ENI+ GN
Sbjct: 434 STIVNLLQRFYDPTKGKVSIDGVDLKEINVHSLREQIGIVSQEPVLFDGTIYENIKMGNE 493
Query: 2346 NVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILL 2167
+ + ++ A + ANA DF+ P G T VGE+G QLSGGQKQRIAIAR LV+NPKILL
Sbjct: 494 HATHDQVVEACKMANANDFIKRLPDGYGTRVGEKGVQLSGGQKQRIAIARALVKNPKILL 553
Query: 2166 LDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHD 1987
LDEATSALD E+E+ VQ AL+ A GRTT++VAHRLSTIRN KI V + G IVE G+H+
Sbjct: 554 LDEATSALDTEAEREVQAALDQAQAGRTTLIVAHRLSTIRNVDKIFVFKAGNIVETGSHE 613
Query: 1986 ELIAKRGVYNDLVQAQLLESHDDHEELPPLAARQLSQELSP-LHSYAIQRSTSNDAGVHD 1810
EL+ K+GV+ D+ QAQ++ A + + +S HS+ ++S++ A
Sbjct: 614 ELMNKQGVFYDMTQAQVVRQQQQE------AGKDIEDTISESAHSHLSRKSSTRSAISMA 667
Query: 1809 DDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYE 1630
+ ++ +E+ + A + + +I R + +FG+ I G P+ A + +
Sbjct: 668 TSIHQLAEEVEECKAPPTPISKIFNFNRDKIWWFIGGMFGAFIFGSVTPVFALVYAEIFN 727
Query: 1629 GFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSL 1450
++ E M + W F+ + + + + G+ E L+ +LR ++F +++
Sbjct: 728 VYSEPVEQMQSDVYFWCGMFVLMGITFFIGFFISANCLGRCGESLTMKLRFEAFKNLMRQ 787
Query: 1449 PCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTL 1270
AFYDD H +L R TD+ NV+ V RL V+ ++V I A+ Y W++ L
Sbjct: 788 DIAFYDDLRHGTGKLCTRFATDAPNVRY-VFTRLPVVLASIVTILGALGIGFYYGWQLAL 846
Query: 1269 EVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSL 1090
+++ P DT E + + A +A+E++RTV +LN +++
Sbjct: 847 ILVVMVPLLVMGGYFEMQMRFGKQIRDTQLLEEAGKVASQAVEHIRTVHSLNRQEQFHFT 906
Query: 1089 ISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLM 910
E+L++ + K A GA S S F+Y+V+F G+ + + P+D Y V
Sbjct: 907 YCEYLREPFNTNLKHAHTYGAVFAFSQSLIFFMYAVAFYLGSIFVNQHSMQPIDVYRVFF 966
Query: 909 TLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGENV 730
+S M G+ +++PD KA AA L+F+L +P + S G G I N+
Sbjct: 967 AISFCGQMIGNTTSFIPDVVKARLAASLLFYLIEHPTPIDSLSEAGIVKPITGNISIRNI 1026
Query: 729 QFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSEN 550
F+Y R + +L G + + PG+T+ALVG SGCGKSTI+ LLERFY+ G + ID +N
Sbjct: 1027 FFNYPTRKETKVLQGFTIDIKPGQTVALVGHSGCGKSTIMGLLERFYNQDKGMIMIDGDN 1086
Query: 549 VEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQF 370
+ ++N++ LR + +VSQEPTLF+C+I EN+ YG R+V E+ +A + AN NF+
Sbjct: 1087 IRNLNISSLRQQVCIVSQEPTLFDCTIGENICYGTNRNVTYQEIVEAAKMANIHNFILGL 1146
Query: 369 PQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTA 190
P G DT VGE+G QLSGGQKQRIAIARA++R+P VLLLDEATSALD++SEK+VQ ALD A
Sbjct: 1147 PDGYDTHVGEKGTQLSGGQKQRIAIARALVRSPSVLLLDEATSALDTESEKIVQEALDAA 1206
Query: 189 SERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGI 25
+ + +V+AHRLST+ N+D IA++ GK+ ++GTH+EL+RK IY +L + Q I
Sbjct: 1207 KQGRTCLVIAHRLSTIQNSDVIAIVSEGKIVDKGTHDELMRKSEIYQKLCETQRI 1261
Score = 291 bits (745), Expect = 8e-77
Identities = 186/590 (31%), Positives = 295/590 (49%), Gaps = 23/590 (3%)
Frame = -1
Query: 1722 DYCFLFIAVFGSAIQGVSYPILAQLI-------VRTYEGFAMIGEDMLYYSHLWALS--- 1573
D L + + I G +P+LA ++ +R ++G + + L +S
Sbjct: 46 DLILLIVGTIAAVIHGAGFPLLAIVLGGMTTVFLRAQNSDFVVGVGNVNPNGLEPISIDE 105
Query: 1572 -----------FMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDP 1426
++ L V +T Y Q F +E L +LR +L ++D
Sbjct: 106 FNSEVVKYCIYYLILGVAMFVTSYVQIACFESYAENLVHKLRQNYLKAILRQQIQWFD-- 163
Query: 1425 NHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPX 1246
L+ RL D V+ + D+ ++ A Y W MTL ++ F P
Sbjct: 164 KQQTGNLTARLTDDLERVREGLGDKFALLVQMFAAFLAGYGVGFFYSWSMTLVMMGFAPL 223
Query: 1245 XXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKI 1066
+ + + + A E ++RTV +LN + + L+
Sbjct: 224 IVLSGAKMSKSMATRTKVEQETYAVAGAIAEETFSSIRTVHSLNGHKRELDRFWNALENG 283
Query: 1065 HKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDT-YLVLMTLSMTAN 889
K+ + G G S C Y+++F +G+ L + + V + +
Sbjct: 284 RKTGIVKYCYMGIGVGFSNLCMYSSYALAFWYGSTLIINDPTFDRGLIFTVFFAVLSGST 343
Query: 888 MAGSAAAYLPDYKKAVHAAGLIFHLF-TYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQ 712
G A +L + A AA + + ++P P+S + KG+I +NV F Y
Sbjct: 344 SLGGALPHLASFGTARGAAYTVLRVINSHPKIDPYSLEGLLVDNMKGDISFQNVHFRYPS 403
Query: 711 RPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINL 532
R D +L G++L+V G+ +ALVG SGCGKSTI++LL+RFY G+V ID ++++IN+
Sbjct: 404 RKDIPVLKGISLEVKSGEKIALVGSSGCGKSTIVNLLQRFYDPTKGKVSIDGVDLKEINV 463
Query: 531 NHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDT 352
+ LR + +VSQEP LF+ +I EN+ G + +E A + ANA +F+ + P G T
Sbjct: 464 HSLREQIGIVSQEPVLFDGTIYENIKMGNEHATHDQVVE-ACKMANANDFIKRLPDGYGT 522
Query: 351 LVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLST 172
VGE+G QLSGGQKQRIAIARA+++NPK+LLLDEATSALD+++E+ VQ ALD A +T
Sbjct: 523 RVGEKGVQLSGGQKQRIAIARALVKNPKILLLDEATSALDTEAEREVQAALDQAQAGRTT 582
Query: 171 VVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQ 22
++VAHRLST+ N D I V K G + E G+HEEL+ K+ +++ + Q Q ++
Sbjct: 583 LIVAHRLSTIRNVDKIFVFKAGNIVETGSHEELMNKQGVFYDMTQAQVVR 632
>gi|46394986|gb|AAS91649.1| multidrug resistance protein 1a;
P-glycoprotein [Rattus norvegicus]
Length = 1272
Score = 762 bits (1968), Expect = 0.0
Identities = 451/1267 (35%), Positives = 687/1267 (53%), Gaps = 51/1267 (4%)
Frame = -1
Query: 3678 MEENSN-----NFSTPLLPQSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGF 3514
+EE+ N NFS EKK + + +F+ + ++F LLG L +++ G
Sbjct: 3 LEEDLNGRADKNFSKMGKKSKKEKKEKKPAVSVLTMFRYAGWLDRFYMLLGTLAAIIHGI 62
Query: 3513 CQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFI 3334
P M FG+++ + N NN+++ + Y + + M +++ G I
Sbjct: 63 ALPLMMLVFGDMTD---SFANVGNNRSMSFYNATDIYAKLKDEMTTYAYYYTGIGAGVLI 119
Query: 3333 FASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFN 3154
A +Q ++ +++R+++ ++ ++ +FD G L+T L D++ + E
Sbjct: 120 VAYIQVSLWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVGELNTRLTDDVSKINEGIG 179
Query: 3153 EKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHY 2974
+KI + + F G + F W+L + S + S I + + T K+ Y
Sbjct: 180 DKIGMFFQAMATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELQAY 239
Query: 2973 ANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCN 2794
A AG++A + L A +TV + GQK E+ERY L+ ++ GI++A+ +IS G +
Sbjct: 240 AKAGAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIY 299
Query: 2793 SLNTVVLYVGATMIYS-------------------------------------GTLETAV 2725
+ + + G +++ S E
Sbjct: 300 ASYALAFWYGTSLVISKEYTIGQVLTVFFSVLIGAFSVGQASPNIEAFANARGAAYEVFS 359
Query: 2724 VVRDDNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVG 2545
++ + I+ + GN+ FKN+ FSYP+R D Q+LKG++ V++G+ +ALVG
Sbjct: 360 IIDNKPSIDSFSKSGHKPDNIQGNLEFKNIHFSYPSRKDVQILKGLNLKVKSGQTVALVG 419
Query: 2544 ASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEEN 2365
SG GKST VQLL Y+ G + IDG D+ +N++ LR +IGVVSQEPVLF TTI EN
Sbjct: 420 NSGCGKSTTVQLLQRLYDPIEGEVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAEN 479
Query: 2364 IRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVR 2185
IR+G NV++ EI A+++ANAYDF+ P T+VGERG QLSGGQKQRIAIAR LVR
Sbjct: 480 IRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVR 539
Query: 2184 NPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIV 2005
NPKILLLDEATSALD ESE VVQ AL+ A +GRTTIV+AHRLST+RNA I G IV
Sbjct: 540 NPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIV 599
Query: 2004 EVGNHDELIAKRGVYNDLVQAQLLES-----HDDHEELPPLAARQLSQELSPLHSYAIQR 1840
E GNHDEL+ ++G+Y LV Q + ++ E + +S + S +
Sbjct: 600 EQGNHDELMREKGIYFKLVMTQTAGNEIELGNEACESKDGIDNVDMSSKDSGSSLIRRRS 659
Query: 1839 STSNDAGVHDDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPI 1660
+ + G HD D E E + ++ I+K ++ + + VF + I G P
Sbjct: 660 TRKSIRGPHDQDGELSTKEALDDDVPPASFWRILKLNSTEWPYFVVGVFCAIINGGLQPA 719
Query: 1659 LAQLIVRTYEGFAM--IGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTR 1486
+ + + F E S+L++L F+ L + +T + Q + FGK E L+ R
Sbjct: 720 FSIIFSKVVGVFTKNDTPEIQRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKR 779
Query: 1485 LRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAI 1306
LR F ML +++DDP ++ L+ RL D++ VK A RL + + + I
Sbjct: 780 LRYMVFKSMLRQDISWFDDPKNTTGALTTRLANDAAQVKGATGSRLAVITQNIANLGTGI 839
Query: 1305 TTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTV 1126
+ +Y W++TL +L P +D E S + A EA+EN RTV
Sbjct: 840 IISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTV 899
Query: 1125 RALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRK 946
+L E K ++ ++ LQ +++ K+A + G + + F Y+ F+FG YL R+
Sbjct: 900 VSLTREQKFETMYAQSLQIPYRNALKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVARE 959
Query: 945 EVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKA-VHAAGLIFHLFTYPATMPFSSSDGK 769
+ + LV + A G +++ PDY KA V A+ +I + P +S+ K
Sbjct: 960 LMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKAKVSASHIIRIIEKIPEIDSYSTEGLK 1019
Query: 768 KNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFY 589
N+ +G + V F+Y RP+ +L G++L+ G+TLALVG SGCGKST++ LLERFY
Sbjct: 1020 PNMLEGNVKFNGVMFNYPTRPNIPVLQGLSLEGKKGQTLALVGSSGCGKSTVVQLLERFY 1079
Query: 588 HAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYG-LTRSVPQLELEK 412
+ G V +D + ++ +N+ LR++L +VSQEP LF+CSI EN+ YG +R V E+ K
Sbjct: 1080 DPMAGTVFLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSHEEIVK 1139
Query: 411 ALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALD 232
A + AN F+ P+ +T VG++G QLSGGQKQRIAIARA++R P +LLLDEATSALD
Sbjct: 1140 AAKEANIHQFIDSLPEKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALD 1199
Query: 231 SDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIY 52
++SEKVVQ ALD A E + +V+AHRLST+ NAD I V++NG+V E GTH++LL ++ IY
Sbjct: 1200 TESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGQVKEHGTHQQLLAQKGIY 1259
Query: 51 WRLVQKQ 31
+ +V Q
Sbjct: 1260 FSMVSVQ 1266
>gi|6755048|ref|NP_035206.1| ATP-binding cassette, sub-family B
(MDR/TAP), member 1A; P glycoprotein 3; ATP-binding
cassette, sub-family B (MDR/TAP), member 4; multi-drug
resistance 3; P-glycoprotein; multiple drug resistant 1a
[Mus musculus]
gi|387427|gb|AAA39514.1| P-glycoprotein
Length = 1276
Score = 758 bits (1957), Expect = 0.0
Identities = 445/1260 (35%), Positives = 678/1260 (53%), Gaps = 50/1260 (3%)
Frame = -1
Query: 3660 NFSTPLLPQSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGE 3481
NFS EKK + + +F+ + ++ L+G L +++ G P M FG+
Sbjct: 14 NFSKMGKKSKKEKKEKKPAVSVLTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLIFGD 73
Query: 3480 VSQVLVTITNAINNKT-IDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMK 3304
++ ++ N N T + AD + + E M +++ G I A +Q +
Sbjct: 74 MTDSFASVGNVSKNSTNMSEADKRAMFAKLEEEMTTYAYYYTGIGAGVLIVAYIQVSFWC 133
Query: 3303 YVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFV 3124
+++R+++ ++ ++ +FD G L+T L D++ + E +KI + +
Sbjct: 134 LAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQAM 193
Query: 3123 TDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQT 2944
F G + F W+L + S + S I + + T K+ YA AG++A +
Sbjct: 194 ATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELHAYAKAGAVAEEV 253
Query: 2943 LGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVG 2764
L A +TV + GQK E+ERY L+ ++ GI++A+ +IS G + + + + G
Sbjct: 254 LAAIRTVIAFGGQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYG 313
Query: 2763 ATMIYS-------------------------------------GTLETAVVVRDDNVIEK 2695
+++ S E ++ + I+
Sbjct: 314 TSLVISKEYSIGQVLTVFFSVLIGAFSVGQASPNIEAFANARGAAYEVFKIIDNKPSIDS 373
Query: 2694 DETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVV 2515
+ GN+ FKN+ FSYP+R + Q+LKG++ V++G+ +ALVG SG GKST V
Sbjct: 374 FSKSGHKPDNIQGNLEFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTTV 433
Query: 2514 QLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSL 2335
QL+ Y+ G + IDG D+ +N++ LR +IGVVSQEPVLF TTI ENIR+G +V++
Sbjct: 434 QLMQRLYDPLDGMVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTM 493
Query: 2334 PEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEA 2155
EI A+++ANAYDF+ P T+VGERG +SGGQKQRIAIAR LVRNPKILLLDEA
Sbjct: 494 DEIEKAVKEANAYDFIMKLPHQFDTLVGERGAHVSGGQKQRIAIARALVRNPKILLLDEA 553
Query: 2154 TSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIA 1975
TSALD ESE VVQ AL+ A +GRTTIV+AHRLST+RNA I G IVE GNHDEL+
Sbjct: 554 TSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMR 613
Query: 1974 KRGVYNDLVQAQLL--------ESHDDHEELPPLAARQLSQELSPLHSYAIQRSTSNDAG 1819
++G+Y LV Q E+ +E+ L S + + ++S G
Sbjct: 614 EKGIYFKLVMTQTAGNEIELGNEACKSKDEIDNLDMSSKDSGSSLIRRRSTRKSI---CG 670
Query: 1818 VHDDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVR 1639
HD D + E E ++ I+K ++ + + +F + I G P + + +
Sbjct: 671 PHDQDRKLSTKEALDEDVPPASFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFSK 730
Query: 1638 TYEGFAMIG--EDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFS 1465
F G E S+L++L F+ L + +T + Q + FGK E L+ RLR F
Sbjct: 731 VVGVFTNGGPPETQRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFK 790
Query: 1464 HMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYC 1285
ML +++DDP ++ L+ RL D++ VK A RL + + + I + +Y
Sbjct: 791 SMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGATGSRLAVIFQNIANLGTGIIISLIYG 850
Query: 1284 WKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLED 1105
W++TL +L P +D E S + A EA+EN RTV +L E
Sbjct: 851 WQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQ 910
Query: 1104 KIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDT 925
K ++ ++ LQ +++ K+A + G + + F Y+ F+FG YL ++ + +
Sbjct: 911 KFETMYAQSLQIPYRNAMKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVTQQLMTFENV 970
Query: 924 YLVLMTLSMTANMAGSAAAYLPDYKKA-VHAAGLIFHLFTYPATMPFSSSDGKKNIEKGE 748
LV + A G +++ PDY KA V A+ +I + P +S+ K N+ +G
Sbjct: 971 LLVFSAIVFGAMAVGQVSSFAPDYAKATVSASHIIRIIEKTPEIDSYSTQGLKPNMLEGN 1030
Query: 747 IIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEV 568
+ V F+Y RP +L G++L+V G+TLALVG SGCGKST++ LLERFY + G V
Sbjct: 1031 VQFSGVVFNYPTRPSIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSV 1090
Query: 567 KIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYG-LTRSVPQLELEKALQTANA 391
+D + ++ +N+ LR+ L +VSQEP LF+CSI EN+ YG +R V E+ +A + AN
Sbjct: 1091 FLDGKEIKQLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSYEEIVRAAKEANI 1150
Query: 390 FNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVV 211
F+ P +T VG++G QLSGGQKQRIAIARA++R P +LLLDEATSALD++SEKVV
Sbjct: 1151 HQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVV 1210
Query: 210 QNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
Q ALD A E + +V+AHRLST+ NAD I V++NGKV E GTH++LL ++ IY+ +V Q
Sbjct: 1211 QEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQ 1270
>gi|266517|sp|P21447|MDR3_MOUSE Multidrug resistance protein 3
(P-glycoprotein 3) (MDR1A)
gi|110720|pir||A34786 multidrug resistance protein 1a - mouse
gi|387429|gb|AAA39517.1| multidrug resistance protein
Length = 1276
Score = 758 bits (1957), Expect = 0.0
Identities = 446/1260 (35%), Positives = 678/1260 (53%), Gaps = 50/1260 (3%)
Frame = -1
Query: 3660 NFSTPLLPQSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGE 3481
NFS EKK + + +F+ + ++ L+G L +++ G P M FG+
Sbjct: 14 NFSKMGKKSKKEKKEKKPAVSVLTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLIFGD 73
Query: 3480 VSQVLVTITNAINNKT-IDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMK 3304
++ ++ N N T + AD + + E M +++ G I A +Q +
Sbjct: 74 MTDSFASVGNVSKNSTNMSEADKRAMFAKLEEEMTTYAYYYTGIGAGVLIVAYIQVSFWC 133
Query: 3303 YVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFV 3124
+++R+++ ++ ++ +FD G L+T L D++ + E +KI + +
Sbjct: 134 LAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQAM 193
Query: 3123 TDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQT 2944
F G + F W+L + S + S I + + T K+ YA AG++A +
Sbjct: 194 ATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELHAYAKAGAVAEEV 253
Query: 2943 LGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVG 2764
L A +TV + GQK E+ERY L+ ++ GI++A+ +IS G + + + + G
Sbjct: 254 LAAIRTVIAFGGQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYG 313
Query: 2763 ATMIYS-------------------------------------GTLETAVVVRDDNVIEK 2695
+++ S E ++ + I+
Sbjct: 314 TSLVISKEYSIGQVLTVFFSVLIGAFSVGQASPNIEAFANARGAAYEVFKIIDNKPSIDS 373
Query: 2694 DETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVV 2515
+ GN+ FKN+ FSYP+R + Q+LKG++ V++G+ +ALVG SG GKST V
Sbjct: 374 FSKSGHKPDNIQGNLEFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTTV 433
Query: 2514 QLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSL 2335
QL+ Y+ G + IDG D+ +N++ LR +IGVVSQEPVLF TTI ENIR+G +V++
Sbjct: 434 QLMQRLYDPLDGMVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTM 493
Query: 2334 PEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEA 2155
EI A+++ANAYDF+ P T+VGERG QLSGGQKQRIAIAR LVRNPKILLLDEA
Sbjct: 494 DEIEKAVKEANAYDFIMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEA 553
Query: 2154 TSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIA 1975
TSALD ESE VVQ AL+ A +GRTTIV+AHRLST+RNA I G IVE GNHDEL+
Sbjct: 554 TSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMR 613
Query: 1974 KRGVYNDLVQAQLL--------ESHDDHEELPPLAARQLSQELSPLHSYAIQRSTSNDAG 1819
++G+Y LV Q E+ +E+ L S + + ++S G
Sbjct: 614 EKGIYFKLVMTQTAGNEIELGNEACKSKDEIDNLDMSSKDSGSSLIRRRSTRKSI---CG 670
Query: 1818 VHDDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVR 1639
HD D + E E ++ I+K ++ + + +F + I G P + + +
Sbjct: 671 PHDQDRKLSTKEALDEDVPPASFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFSK 730
Query: 1638 TYEGFAMIG--EDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFS 1465
F G E S+L++L F+ L + +T + Q + FGK E L+ RLR F
Sbjct: 731 VVGVFTNGGPPETQRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFK 790
Query: 1464 HMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYC 1285
ML +++DDP ++ L+ RL D++ VK A RL + + + I + +Y
Sbjct: 791 SMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGATGSRLAVIFQNIANLGTGIIISLIYG 850
Query: 1284 WKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLED 1105
W++TL +L P +D E S + A EA+EN RTV +L E
Sbjct: 851 WQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQ 910
Query: 1104 KIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDT 925
K ++ ++ LQ +++ K+A + G + + F Y+ F+FG YL ++ + +
Sbjct: 911 KFETMYAQSLQIPYRNAMKKAHVFGITFFFTQAMMYFSYAACFRFGAYLVTQQLMTFENV 970
Query: 924 YLVLMTLSMTANMAGSAAAYLPDYKKA-VHAAGLIFHLFTYPATMPFSSSDGKKNIEKGE 748
LV + A G +++ PDY KA V A+ +I + P +S+ K N+ +G
Sbjct: 971 LLVFSAIVFGAMAVGQVSSFAPDYAKATVSASHIIRIIEKTPEIDSYSTQGLKPNMLEGN 1030
Query: 747 IIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEV 568
+ F+Y RP +L G++L+V G+TLALVG SGCGKST++ LLERFY + G V
Sbjct: 1031 VQFSGFVFNYPTRPSIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSV 1090
Query: 567 KIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYG-LTRSVPQLELEKALQTANA 391
+D + ++ +N+ LR+ L +VSQEP LF+CSI EN+ YG +R V E+ +A + AN
Sbjct: 1091 FLDGKEIKQLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSYEEIVRAAKEANI 1150
Query: 390 FNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVV 211
F+ P +T VG++G QLSGGQKQRIAIARA++R P +LLLDEATSALD++SEKVV
Sbjct: 1151 HQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVV 1210
Query: 210 QNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
Q ALD A E + +V+AHRLST+ NAD I V++NGKV E GTH++LL ++ IY+ +V Q
Sbjct: 1211 QEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQ 1270
>gi|17508505|ref|NP_491707.1| P-GlycoProtein related (pgp-2)
[Caenorhabditis elegans]
gi|15617726|gb|AAB52482.2| P-glycoprotein related protein 2
[Caenorhabditis elegans]
Length = 1265
Score = 758 bits (1956), Expect = 0.0
Identities = 445/1255 (35%), Positives = 692/1255 (54%), Gaps = 47/1255 (3%)
Frame = -1
Query: 3648 PLLPQSDEKKPSQICSFIRV----VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGE 3481
PLL +S S S +++ +F + + L + G + +++ G P ++ G
Sbjct: 14 PLLKRSHSSDSSIDESTVKLTNYGIFYYTQGVDLLLLITGTVAAVIHGAGFPLLAIVLGG 73
Query: 3480 VSQVLVTITNA---INNKTIDPADLEK-AYEEYERGMNQVVFHFFLCGCAYFIFASLQHA 3313
++ V + N+ + ++P L + +E+ + + ++ + G F + +Q A
Sbjct: 74 MTTVFLRAQNSDFVVGVDNVNPEGLVPISLDEFNSEVVKYCIYYLVLGVLMFFTSYVQIA 133
Query: 3312 IMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALII 3133
+ + +++R+ Y+ +L++ Q+FD TG+L+ L D+LER RE +K AL++
Sbjct: 134 CFESYAERLVHKLRQNYLKAILRQQIQWFDKQQTGNLTARLTDDLERVREGLGDKFALLV 193
Query: 3132 AFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIA 2953
F G + F+ W + + F+ I SG S + T + YA AG+IA
Sbjct: 194 QMFAAFLAGYGVGFFYSWSMTLVMMGFAPLIVLSGAKMSKSMATRTRVEQETYAVAGAIA 253
Query: 2952 FQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVL 2773
+T + +TV SLNG K E++R+ L+ G + GI + I G + S +
Sbjct: 254 EETFSSIRTVHSLNGHKRELDRFYNALEVGRQTGIVKYCYMGIGVGFSNLCMYSSYALAF 313
Query: 2772 YVGATMIYS---------------------------------GTLETAV-----VVRDDN 2707
+ G+T+I + GT A V+
Sbjct: 314 WYGSTLIINDPTFDRGLIFTVFFAVLSGSTSLGGALPHLASFGTARGAASTVLRVINSHP 373
Query: 2706 VIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGK 2527
I+ + + + G+ISFK+V F YP+R D VLKGIS +++ G+ IALVG+SG GK
Sbjct: 374 KIDPYSLEGILVDNMKGDISFKDVHFRYPSRKDIHVLKGISLELKAGDKIALVGSSGCGK 433
Query: 2526 STVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNP 2347
ST+V LL +Y+ G + IDG+DL ++N+ LR IG+VSQEPVLF+ TI ENI+ GN
Sbjct: 434 STIVNLLQRFYDPTKGRVLIDGVDLREVNVHSLREQIGIVSQEPVLFDGTIYENIKMGNE 493
Query: 2346 NVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILL 2167
+ + ++ A + ANA DF+ P G T VGE+G QLSGGQKQRIAIAR LV+NPKILL
Sbjct: 494 HATHDQVVEACKMANANDFIKRLPDGYGTRVGEKGVQLSGGQKQRIAIARALVKNPKILL 553
Query: 2166 LDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHD 1987
LDEATSALD E+E+ VQ AL+ A GRTTI+VAHRLSTIRN +I V + G IVE G+H+
Sbjct: 554 LDEATSALDTEAEREVQGALDQAQAGRTTIIVAHRLSTIRNVDRIFVFKAGNIVESGSHE 613
Query: 1986 ELIAKRGVYNDLVQAQLLESHDDHEELPPLAARQLSQELSP-LHSYAIQRSTSNDAGVHD 1810
EL++K+G++ D+ QAQ++ A + + +S HS+ ++S++ A
Sbjct: 614 ELMSKQGIFYDMTQAQVVRQQQQE------AGKDIEDTISESAHSHLSRKSSTRSAISIA 667
Query: 1809 DDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYE 1630
+ ++ +E+ + A +++ +I K + +FG+ I G P+ A + +
Sbjct: 668 TSIHQLAEEVEECKAPPTSMFKIFKFNGDKVGWFIGGIFGAFIFGSVTPVFALVYAEIFN 727
Query: 1629 GFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSL 1450
+++ + M + W F+ + + + + G+ E L+ +LR ++F ++L
Sbjct: 728 VYSLPADQMQANVYFWCGMFVLMGITFFVGFFTSANCLGRCGESLTMKLRFEAFKNLLRQ 787
Query: 1449 PCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTL 1270
AFYDD H +L R TD+ NV+ V RL V+ ++V I A+ Y W++ L
Sbjct: 788 DIAFYDDLRHGTGKLCTRFATDAPNVRY-VFTRLPVVLASIVTICGALGIGFYYGWQLAL 846
Query: 1269 EVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSL 1090
+++ P DT E + + A +A+E++RTV +LN +++
Sbjct: 847 ILVVMVPLLVMGGYFEMQMRFGKQIRDTQLLEEAGKVASQAVEHIRTVHSLNRQEQFHFT 906
Query: 1089 ISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLM 910
E+L++ + K A GA S S F+Y+ +F G+ ++ + P+D Y V
Sbjct: 907 YCEYLREPFNTNLKHAHTYGAVFAFSQSLIFFMYAAAFYLGSIFVNQQAMQPIDVYRVFF 966
Query: 909 TLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGENV 730
+S M G+ +++PD KA AA L+F+L +P + S G G I NV
Sbjct: 967 AISFCGQMIGNTTSFIPDVVKARLAASLLFYLIEHPTPIDSLSDSGIVKPITGNISIRNV 1026
Query: 729 QFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSEN 550
F+Y R D +L G L + GKT+ALVG SGCGKSTI+ LLERFY+ G + ID +N
Sbjct: 1027 FFNYPTRKDTKVLQGFTLDIKAGKTVALVGHSGCGKSTIMGLLERFYNQDKGMIMIDGDN 1086
Query: 549 VEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQF 370
+ ++N++ LR + +VSQEPTLF+C+I EN+ YG R+V E+ +A + AN NF+
Sbjct: 1087 IRNLNISSLREQVCIVSQEPTLFDCTIGENICYGTNRNVTYQEIVEAAKMANIHNFILGL 1146
Query: 369 PQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTA 190
P G DT VGE+G QLSGGQKQRIAIARA++R+P VLLLDEATSALD++SEK+VQ ALD A
Sbjct: 1147 PDGYDTHVGEKGTQLSGGQKQRIAIARALVRSPSVLLLDEATSALDTESEKIVQEALDAA 1206
Query: 189 SERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGI 25
+ + +V+AHRLST+ N+D IA++ GK+ E+GTH+EL+RK IY + + Q I
Sbjct: 1207 KQGRTCLVIAHRLSTIQNSDVIAIVSEGKIVEKGTHDELIRKSEIYQKFCETQRI 1261
Score = 286 bits (733), Expect = 2e-75
Identities = 184/590 (31%), Positives = 291/590 (49%), Gaps = 23/590 (3%)
Frame = -1
Query: 1722 DYCFLFIAVFGSAIQGVSYPILAQLI-------VRTYEGFAMIGEDMLYYSHLWALS--- 1573
D L + I G +P+LA ++ +R ++G D + L +S
Sbjct: 46 DLLLLITGTVAAVIHGAGFPLLAIVLGGMTTVFLRAQNSDFVVGVDNVNPEGLVPISLDE 105
Query: 1572 -----------FMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDP 1426
++ L V T Y Q F +E+L +LR +L ++D
Sbjct: 106 FNSEVVKYCIYYLVLGVLMFFTSYVQIACFESYAERLVHKLRQNYLKAILRQQIQWFD-- 163
Query: 1425 NHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPX 1246
L+ RL D V+ + D+ ++ A Y W MTL ++ F P
Sbjct: 164 KQQTGNLTARLTDDLERVREGLGDKFALLVQMFAAFLAGYGVGFFYSWSMTLVMMGFAPL 223
Query: 1245 XXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKI 1066
+ + + + A E ++RTV +LN + + L+
Sbjct: 224 IVLSGAKMSKSMATRTRVEQETYAVAGAIAEETFSSIRTVHSLNGHKRELDRFYNALEVG 283
Query: 1065 HKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDT-YLVLMTLSMTAN 889
++ + G G S C Y+++F +G+ L + + V + +
Sbjct: 284 RQTGIVKYCYMGIGVGFSNLCMYSSYALAFWYGSTLIINDPTFDRGLIFTVFFAVLSGST 343
Query: 888 MAGSAAAYLPDYKKAVHAAGLIFHLF-TYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQ 712
G A +L + A AA + + ++P P+S + KG+I ++V F Y
Sbjct: 344 SLGGALPHLASFGTARGAASTVLRVINSHPKIDPYSLEGILVDNMKGDISFKDVHFRYPS 403
Query: 711 RPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINL 532
R D +L G++L++ G +ALVG SGCGKSTI++LL+RFY G V ID ++ ++N+
Sbjct: 404 RKDIHVLKGISLELKAGDKIALVGSSGCGKSTIVNLLQRFYDPTKGRVLIDGVDLREVNV 463
Query: 531 NHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDT 352
+ LR + +VSQEP LF+ +I EN+ G + +E A + ANA +F+ + P G T
Sbjct: 464 HSLREQIGIVSQEPVLFDGTIYENIKMGNEHATHDQVVE-ACKMANANDFIKRLPDGYGT 522
Query: 351 LVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLST 172
VGE+G QLSGGQKQRIAIARA+++NPK+LLLDEATSALD+++E+ VQ ALD A +T
Sbjct: 523 RVGEKGVQLSGGQKQRIAIARALVKNPKILLLDEATSALDTEAEREVQGALDQAQAGRTT 582
Query: 171 VVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQ 22
++VAHRLST+ N D I V K G + E G+HEEL+ K+ I++ + Q Q ++
Sbjct: 583 IIVAHRLSTIRNVDRIFVFKAGNIVESGSHEELMSKQGIFYDMTQAQVVR 632
>gi|307180|gb|AAA59575.1| P-glycoprotein [Homo sapiens]
Length = 1280
Score = 757 bits (1954), Expect = 0.0
Identities = 452/1253 (36%), Positives = 681/1253 (54%), Gaps = 54/1253 (4%)
Frame = -1
Query: 3627 EKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNA 3448
EKKP+ + +F+ S+ +K ++G L +++ G P M FGE++ + N
Sbjct: 29 EKKPTVS---VFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNL 85
Query: 3447 --INNKTIDPADLEKA--YEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTY 3280
+ + + +D+ + E M + +++ G + A +Q + +
Sbjct: 86 EDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIH 145
Query: 3279 RVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTA 3100
++RKQ+ +++++ +FD G L+T L D++ + EV +KI + + F G
Sbjct: 146 KIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEVIGDKIGMFFQSMATFFTGFI 205
Query: 3099 LAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVC 2920
+ F W+L + S + S + + + T K+ YA AG++A + L A +TV
Sbjct: 206 VGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVI 265
Query: 2919 SLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYSG- 2743
+ GQK E+ERY + L+ ++ GI++A+ +IS G + + + + G T++ SG
Sbjct: 266 AFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGE 325
Query: 2742 ------------------------------------TLETAVVVRDDNVIEKDETDYDVE 2671
E ++ + I+
Sbjct: 326 YSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKP 385
Query: 2670 VEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYN 2491
+ GN+ F+NV FSYP+R + ++LKG++ VQ+G+ +ALVG SG GKST VQL+ Y+
Sbjct: 386 DNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYD 445
Query: 2490 IDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALR 2311
G + +DG D+ +N++ LR +IGVVSQEPVLF TTI ENIR+G NV++ EI A++
Sbjct: 446 PTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVK 505
Query: 2310 KANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNES 2131
+ANAYDF+ P T+VGERG QLSGGQKQRIAIAR LVRNPKILLLDEATSALD ES
Sbjct: 506 EANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTES 565
Query: 2130 EQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDL 1951
E VVQ AL+ A +GRTTIV+AHRLST+RNA I G IVE GNHDEL+ ++G+Y L
Sbjct: 566 EAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKL 625
Query: 1950 VQAQLLESHDDHEELPPLAARQLSQELSPLH--------SYAIQRSTSNDA-GVHDDDME 1798
V Q + + E AA + E+ L S +RST G D +
Sbjct: 626 VTMQTAGNEVELEN----AADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRK 681
Query: 1797 RILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAM 1618
E E + I+K ++ + + VF + I G P A + + F
Sbjct: 682 LSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTR 741
Query: 1617 IG--EDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPC 1444
I E S+L++L F+ L + +T + Q + FGK E L+ RLR F ML
Sbjct: 742 IDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDV 801
Query: 1443 AFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEV 1264
+++DDP ++ L+ RL D++ VK A+ RL + + + I + +Y W++TL +
Sbjct: 802 SWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLL 861
Query: 1263 LMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLIS 1084
L P +D E + + A EA+EN RTV +L E K + +
Sbjct: 862 LAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTQEQKFEHMYA 921
Query: 1083 EHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTL 904
+ LQ +++ ++A I G + + F Y+ F+FG YL K ++ D LV +
Sbjct: 922 QSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAV 981
Query: 903 SMTANMAGSAAAYLPDYKKA-VHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGENVQ 727
A G +++ PDY KA + AA +I + P +S+ N +G + V
Sbjct: 982 VFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVV 1041
Query: 726 FHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENV 547
F+Y RPD +L G++L+V G+TLALVG SGCGKST++ LLERFY + G+V +D + +
Sbjct: 1042 FNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEI 1101
Query: 546 EDINLNHLRSNLALVSQEPTLFNCSIRENLLYG-LTRSVPQLELEKALQTANAFNFVFQF 370
+ +N+ LR++L +VSQEP LF+CSI EN+ YG +R V Q E+ +A + AN F+
Sbjct: 1102 KRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESL 1161
Query: 369 PQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTA 190
P T VG++G QLSGGQKQRIAIARA++R P +LLLDEATSALD++SEKVVQ ALD A
Sbjct: 1162 PNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKA 1221
Query: 189 SERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
E + +V+AHRLST+ NAD I V +NG+V E GTH++LL ++ IY+ +V Q
Sbjct: 1222 REGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ 1274
Score = 319 bits (817), Expect = 4e-85
Identities = 194/540 (35%), Positives = 298/540 (54%), Gaps = 3/540 (0%)
Frame = -1
Query: 1626 FAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLP 1447
F + EDM Y++ ++ + V Y Q ++ + + ++R + F ++
Sbjct: 104 FMNLEEDMTRYAYYYSGIGAGVLV----AAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQE 159
Query: 1446 CAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLE 1267
++D H L+ RL D S + + D++G ++ WK+TL
Sbjct: 160 IGWFDV--HDVGELNTRLTDDVSKINEVIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLV 217
Query: 1266 VLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLI 1087
+L P ++ +A+ + A E L +RTV A + K +
Sbjct: 218 ILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERY 277
Query: 1086 SEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMT 907
+++L++ + K+AI + G + Y+++F +GT L L E + V +
Sbjct: 278 NKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFS 337
Query: 906 LSMTANMAGSAAAYLPDYKKAVHAAGLIFHLF-TYPATMPFSSSDGKKNIEKGEIIGENV 730
+ + A G A+ + + A AA IF + P+ +S S K + KG + NV
Sbjct: 338 VLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNV 397
Query: 729 QFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSEN 550
F Y R + IL G+NLKV G+T+ALVG SGCGKST + L++R Y +G V +D ++
Sbjct: 398 HFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQD 457
Query: 549 VEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQF 370
+ IN+ LR + +VSQEP LF +I EN+ YG +V E+EKA++ ANA++F+ +
Sbjct: 458 IRTINVRFLREIIGVVSQEPVLFATTIAENIRYG-RENVTMDEIEKAVKEANAYDFIMKL 516
Query: 369 PQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTA 190
P DTLVGERGAQLSGGQKQRIAIARA++RNPK+LLLDEATSALD++SE VVQ ALD A
Sbjct: 517 PHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKA 576
Query: 189 SERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLV--QKQGIQVE 16
+ +T+V+AHRLSTV NAD IA +G + E+G H+EL++++ IY++LV Q G +VE
Sbjct: 577 RKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVE 636
>gi|2149087|gb|AAB58489.1| multidrug resistance protein-1 [Ovis aries]
Length = 1285
Score = 756 bits (1951), Expect = 0.0
Identities = 451/1256 (35%), Positives = 682/1256 (53%), Gaps = 54/1256 (4%)
Frame = -1
Query: 3636 QSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVL--- 3466
+ DEKK + +F+ S+ ++ +LG L +++ G P M FG+++
Sbjct: 27 KKDEKKEKRPTVSTFTMFRYSNWLDRLCMVLGTLAAIIHGAGLPLMMLVFGDMTDSFAGA 86
Query: 3465 -----VTITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKY 3301
+T++N N TID + K + E+ M +++ G I A +Q +
Sbjct: 87 GNLGNITLSNISNTSTIDRTEYGK---KLEKEMTTYAYYYSGIGAGVLIAAYIQVSFWCL 143
Query: 3300 VGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVT 3121
+R+RKQ+ +++++ +FD G L+T L +++ + E +KI + +
Sbjct: 144 AAGRQVHRIRKQFFHAIMQQEIGWFDVHDVGKLNTRLTNDVSKINEGIGDKIGMFFQAMA 203
Query: 3120 DFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTL 2941
F G + F T W L + + S I + + T K+ YA AG++A + L
Sbjct: 204 TFFTGFIIGFTTGWNLTLVILAIIPVLGLSAAIWAKILSSFTDKKLLAYAKAGAVAEEVL 263
Query: 2940 GAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGA 2761
A KTV + GQK E+ERY + L+ ++ GI++A+ +IS G + + + + G
Sbjct: 264 AAIKTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISMGAAFLLIYASYALAFWYGT 323
Query: 2760 TMIYS-------------------------------------GTLETAVVVRDDNVIEKD 2692
+++ S E ++ + I+
Sbjct: 324 SLVLSREYSIGQVLTVFFSVLIGAFSIGQASPNIEAFANARGAAYEVFKIIDNKPSIDSY 383
Query: 2691 ETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQ 2512
+ GN+ F+NV F YP+R + ++LKG++ V +G+ +ALVG SG GKST VQ
Sbjct: 384 SNTGHKPDNIKGNLEFRNVHFHYPSRNEVKILKGLNLKVGSGQTVALVGNSGCGKSTTVQ 443
Query: 2511 LLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLP 2332
L+ Y+ G + IDG D+ +N++ LR +IGVVSQEPVLF TTI ENIR+G +V++
Sbjct: 444 LMQRLYDPTEGMVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMD 503
Query: 2331 EIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEAT 2152
EI A+++ANAYDF+ P T+VGERG QLSGGQKQRIAIAR LVRNPKILLLDEAT
Sbjct: 504 EIQKAVKEANAYDFIMKLPNKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEAT 563
Query: 2151 SALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAK 1972
SAL ESE VVQ AL+ A +GRTTIV+AHRLST+RNA I + G IVE G+HDEL+ K
Sbjct: 564 SALGTESEAVVQAALDKARKGRTTIVIAHRLSTVRNADIIAGLDDGVIVEEGSHDELMGK 623
Query: 1971 RGVYNDLVQAQLLESHDDHEELPPLAARQ---LSQELSPLHSYAIQRSTSNDA--GVHDD 1807
RG+Y LV Q + + E P + + L S I+R ++ + G
Sbjct: 624 RGIYFKLVTMQTKGNELELENTPGESLSKTDDLYMSSQDSRSSLIRRKSTRRSIRGSQSQ 683
Query: 1806 DMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEG 1627
D + +E E + I+K ++ + + VF + I G P + + R
Sbjct: 684 DRKLSTEETLDESVPPVSFWRILKLNITEWPYFVVGVFCAIINGALQPAFSVIFSRIIGI 743
Query: 1626 FAMIGED--MLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLS 1453
F D S+L++L F+ L + +T + Q + FGK E L+ RLR F ML
Sbjct: 744 FTRNDNDETKRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTRRLRYLVFRSMLR 803
Query: 1452 LPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMT 1273
+++DDP ++ L+ RL D++ VK AV RL + + + I + +Y W++T
Sbjct: 804 QDVSWFDDPKNTTGALTTRLANDAAQVKGAVGSRLAVITQNIANLGTGIIISLIYGWQLT 863
Query: 1272 LEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMS 1093
L +L P +D E + + A EA+EN RTV +L E++
Sbjct: 864 LLLLAIVPIIAVAGVIEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTREERFEY 923
Query: 1092 LISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVL 913
+ ++ LQ +++ +RA + G ++ + F Y+ F+FG YL + + D LV
Sbjct: 924 MYAQSLQVPYRNSLRRAHVFGITFSITQAMMYFSYAGCFRFGAYLVAQGIMEFQDVLLVF 983
Query: 912 MTLSMTANMAGSAAAYLPDYKKA-VHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGE 736
+ A G + + PDY KA V AA +I + P +S+ K + +G +
Sbjct: 984 SAVVFGAMAVGQVSTFAPDYAKAKVSAAHVINIIEKIPLIDSYSTEGLKPSTVEGSVAFN 1043
Query: 735 NVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDS 556
+V F+Y RPD +L G++L+V G+TLALVG SGCGKST++ LLERFY + G V ID
Sbjct: 1044 DVVFNYPTRPDVPVLRGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFIDG 1103
Query: 555 ENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYG-LTRSVPQLELEKALQTANAFNFV 379
+ V+ +N+ LR+++ +VSQEP LF+CSI EN+ YG +R V Q E+E A + AN +F+
Sbjct: 1104 KEVKQLNVQWLRAHMGIVSQEPILFDCSIGENIAYGDNSRVVSQEEIEHAAKEANIHSFI 1163
Query: 378 FQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNAL 199
P +T VG++G QLSGGQKQRIAIARA++R P +LLLDEATSALD++SEKVVQ AL
Sbjct: 1164 EMLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEAL 1223
Query: 198 DTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
D A E + +V+AHRLST+ NAD I V +NG++ E GTH++LL ++ IY+ +V Q
Sbjct: 1224 DKAREGRTCIVIAHRLSTIQNADLIVVFQNGRIKEHGTHQQLLAQKGIYFTMVSVQ 1279
>gi|2353264|gb|AAB69423.1| P-glycoprotein [Homo sapiens]
Length = 1279
Score = 755 bits (1950), Expect = 0.0
Identities = 453/1252 (36%), Positives = 682/1252 (54%), Gaps = 53/1252 (4%)
Frame = -1
Query: 3627 EKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNA 3448
EKKP+ + +F+ S+ +K ++G L +++ G P M FGE++ + N
Sbjct: 29 EKKPTVS---VFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNL 85
Query: 3447 --INNKTIDPADLEKA--YEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTY 3280
+ + + +D+ + E M + +++ G + A +Q + +
Sbjct: 86 EDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIH 145
Query: 3279 RVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTA 3100
++RKQ+ +++++ +FD G L+T L D++ + E +KI + + F G
Sbjct: 146 KIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFI 205
Query: 3099 LAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVC 2920
+ F W+L + S + S + + + T K+ YA AG++A + L A +TV
Sbjct: 206 VGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVI 265
Query: 2919 SLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYSGT 2740
+ GQK E+ERY + L+ ++ GI++A+ +IS G + + + + G T++ SG
Sbjct: 266 AFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGE 325
Query: 2739 LETAVVVRDDNVI----EKDETDYDVEVEVN----------------------------- 2659
V+ +V+ + +E N
Sbjct: 326 YSIGQVLTVFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPD 385
Query: 2658 ---GNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNI 2488
GN+ F+NV FSYP+R + ++LKG++ VQ+G+ +ALVG SG GKST VQL+ Y+
Sbjct: 386 NIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDP 445
Query: 2487 DSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRK 2308
G + +DG D+ +N++ LR +IGVVSQEPVLF TTI ENIR+G NV++ EI A+++
Sbjct: 446 TEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKE 505
Query: 2307 ANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESE 2128
ANAYDF+ P T+VGERG QLSGGQKQRIAIAR LVRNPKILLLDEATSALD ESE
Sbjct: 506 ANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESE 565
Query: 2127 QVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLV 1948
VVQ AL+ A +GRTTIV+AHRLST+RNA I G IVE GNHDEL+ ++G+Y LV
Sbjct: 566 AVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLV 625
Query: 1947 QAQLLESHDDHEELPPLAARQLSQELSPLH--------SYAIQRSTSNDA-GVHDDDMER 1795
Q + + E AA + E+ L S +RST G D +
Sbjct: 626 TMQTAGNEVELEN----AADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKL 681
Query: 1794 ILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMI 1615
E E + I+K ++ + + VF + I G P A + + F I
Sbjct: 682 STKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRI 741
Query: 1614 G--EDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCA 1441
E S+L++L F+ L + +T + Q + FGK E L+ RLR F ML +
Sbjct: 742 DDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVS 801
Query: 1440 FYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVL 1261
++DDP ++ L+ RL D++ VK A+ RL + + + I + +Y W++TL +L
Sbjct: 802 WFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLL 861
Query: 1260 MFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISE 1081
P +D E + + A EA+EN RTV +L E K + ++
Sbjct: 862 AIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTQEQKFEHMYAQ 921
Query: 1080 HLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLS 901
LQ +++ ++A I G + + F Y+ F+FG YL K ++ D LV +
Sbjct: 922 SLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVV 981
Query: 900 MTANMAGSAAAYLPDYKKA-VHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGENVQF 724
A G +++ PDY KA + AA +I + P +S+ N +G + V F
Sbjct: 982 FGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVF 1041
Query: 723 HYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVE 544
+Y RPD +L G++L+V G+TLALVG SGCGKST++ LLERFY + G+V +D + ++
Sbjct: 1042 NYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIK 1101
Query: 543 DINLNHLRSNLALVSQEPTLFNCSIRENLLYG-LTRSVPQLELEKALQTANAFNFVFQFP 367
+N+ LR++L +VSQEP LF+CSI EN+ YG +R V Q E+ +A + AN F+ P
Sbjct: 1102 RLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLP 1161
Query: 366 QGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTAS 187
T VG++G QLSGGQKQRIAIARA++R P +LLLDEATSALD++SEKVVQ ALD A
Sbjct: 1162 NKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAR 1221
Query: 186 ERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
E + +V+AHRLST+ NAD I V +NG+V E GTH++LL ++ IY+ +V Q
Sbjct: 1222 EGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ 1273
Score = 317 bits (812), Expect = 1e-84
Identities = 194/540 (35%), Positives = 300/540 (54%), Gaps = 3/540 (0%)
Frame = -1
Query: 1626 FAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLP 1447
F + EDM Y++ ++ + V Y Q ++ + + ++R + F ++
Sbjct: 104 FMNLEEDMTRYAYYYSGIGAGVLV----AAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQE 159
Query: 1446 CAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLE 1267
++D H L+ RL D S + + D++G ++ WK+TL
Sbjct: 160 IGWFDV--HDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLV 217
Query: 1266 VLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLI 1087
+L P ++ +A+ + A E L +RTV A + K +
Sbjct: 218 ILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERY 277
Query: 1086 SEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMT 907
+++L++ + K+AI + G + Y+++F +GT L L E + + L + +
Sbjct: 278 NKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYS-IGQVLTVFS 336
Query: 906 LSMTANMAGSAAAYLPDYKKAVHAAGLIFHLF-TYPATMPFSSSDGKKNIEKGEIIGENV 730
+ + A G A+ + + A AA IF + P+ +S S K + KG + NV
Sbjct: 337 VLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNV 396
Query: 729 QFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSEN 550
F Y R + IL G+NLKV G+T+ALVG SGCGKST + L++R Y +G V +D ++
Sbjct: 397 HFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQD 456
Query: 549 VEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQF 370
+ IN+ LR + +VSQEP LF +I EN+ YG +V E+EKA++ ANA++F+ +
Sbjct: 457 IRTINVRFLREIIGVVSQEPVLFATTIAENIRYG-RENVTMDEIEKAVKEANAYDFIMKL 515
Query: 369 PQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTA 190
P DTLVGERGAQLSGGQKQRIAIARA++RNPK+LLLDEATSALD++SE VVQ ALD A
Sbjct: 516 PHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKA 575
Query: 189 SERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLV--QKQGIQVE 16
+ +T+V+AHRLSTV NAD IA +G + E+G H+EL++++ IY++LV Q G +VE
Sbjct: 576 RKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVE 635
>gi|42741659|ref|NP_000918.2| ATP-binding cassette sub-family B member
1; multidrug resistance 1; P glycoprotein 1; doxorubicin
resistance; colchicin sensitivity [Homo sapiens]
Length = 1280
Score = 755 bits (1950), Expect = 0.0
Identities = 452/1253 (36%), Positives = 680/1253 (54%), Gaps = 54/1253 (4%)
Frame = -1
Query: 3627 EKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNA 3448
EKKP+ + +F+ S+ +K ++G L +++ G P M FGE++ + N
Sbjct: 29 EKKPTVS---VFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNL 85
Query: 3447 --INNKTIDPADLEKA--YEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTY 3280
+ + + +D+ + E M + +++ G + A +Q + +
Sbjct: 86 EDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIH 145
Query: 3279 RVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTA 3100
++RKQ+ +++++ +FD G L+T L D++ + E +KI + + F G
Sbjct: 146 KIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFI 205
Query: 3099 LAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVC 2920
+ F W+L + S + S + + + T K+ YA AG++A + L A +TV
Sbjct: 206 VGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVI 265
Query: 2919 SLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYSG- 2743
+ GQK E+ERY + L+ ++ GI++A+ +IS G + + + + G T++ SG
Sbjct: 266 AFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGE 325
Query: 2742 ------------------------------------TLETAVVVRDDNVIEKDETDYDVE 2671
E ++ + I+
Sbjct: 326 YSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKP 385
Query: 2670 VEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYN 2491
+ GN+ F+NV FSYP+R + ++LKG++ VQ+G+ +ALVG SG GKST VQL+ Y+
Sbjct: 386 DNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYD 445
Query: 2490 IDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALR 2311
G + +DG D+ +N++ LR +IGVVSQEPVLF TTI ENIR+G NV++ EI A++
Sbjct: 446 PTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVK 505
Query: 2310 KANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNES 2131
+ANAYDF+ P T+VGERG QLSGGQKQRIAIAR LVRNPKILLLDEATSALD ES
Sbjct: 506 EANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTES 565
Query: 2130 EQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDL 1951
E VVQ AL+ A +GRTTIV+AHRLST+RNA I G IVE GNHDEL+ ++G+Y L
Sbjct: 566 EAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKL 625
Query: 1950 VQAQLLESHDDHEELPPLAARQLSQELSPLH--------SYAIQRSTSNDA-GVHDDDME 1798
V Q + + E AA + E+ L S +RST G D +
Sbjct: 626 VTMQTAGNEVELEN----AADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRK 681
Query: 1797 RILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAM 1618
E E + I+K ++ + + VF + I G P A + + F
Sbjct: 682 LSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTR 741
Query: 1617 IG--EDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPC 1444
I E S+L++L F+ L + +T + Q + FGK E L+ RLR F ML
Sbjct: 742 IDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDV 801
Query: 1443 AFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEV 1264
+++DDP ++ L+ RL D++ VK A+ RL + + + I + +Y W++TL +
Sbjct: 802 SWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLL 861
Query: 1263 LMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLIS 1084
L P +D E S + A EA+EN RTV +L E K + +
Sbjct: 862 LAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTQEQKFEHMYA 921
Query: 1083 EHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTL 904
+ LQ +++ ++A I G + + F Y+ F+FG YL K ++ D LV +
Sbjct: 922 QSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAV 981
Query: 903 SMTANMAGSAAAYLPDYKKA-VHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGENVQ 727
A G +++ PDY KA + AA +I + P +S+ N +G + V
Sbjct: 982 VFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVV 1041
Query: 726 FHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENV 547
F+Y RPD +L G++L+V G+TLALVG SGCGKST++ LLERFY + G+V +D + +
Sbjct: 1042 FNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEI 1101
Query: 546 EDINLNHLRSNLALVSQEPTLFNCSIRENLLYG-LTRSVPQLELEKALQTANAFNFVFQF 370
+ +N+ LR++L +VSQEP LF+CSI EN+ YG +R V Q E+ +A + AN F+
Sbjct: 1102 KRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESL 1161
Query: 369 PQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTA 190
P T VG++G QLSGGQKQRIAIARA++R P +LLLDEATSALD++SEKVVQ ALD A
Sbjct: 1162 PNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKA 1221
Query: 189 SERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
E + +V+AHRLST+ NAD I V +NG+V E GTH++LL ++ IY+ +V Q
Sbjct: 1222 REGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ 1274
Score = 319 bits (817), Expect = 4e-85
Identities = 194/540 (35%), Positives = 298/540 (54%), Gaps = 3/540 (0%)
Frame = -1
Query: 1626 FAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLP 1447
F + EDM Y++ ++ + V Y Q ++ + + ++R + F ++
Sbjct: 104 FMNLEEDMTRYAYYYSGIGAGVLV----AAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQE 159
Query: 1446 CAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLE 1267
++D H L+ RL D S + + D++G ++ WK+TL
Sbjct: 160 IGWFDV--HDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLV 217
Query: 1266 VLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLI 1087
+L P ++ +A+ + A E L +RTV A + K +
Sbjct: 218 ILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERY 277
Query: 1086 SEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMT 907
+++L++ + K+AI + G + Y+++F +GT L L E + V +
Sbjct: 278 NKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFS 337
Query: 906 LSMTANMAGSAAAYLPDYKKAVHAAGLIFHLF-TYPATMPFSSSDGKKNIEKGEIIGENV 730
+ + A G A+ + + A AA IF + P+ +S S K + KG + NV
Sbjct: 338 VLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNV 397
Query: 729 QFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSEN 550
F Y R + IL G+NLKV G+T+ALVG SGCGKST + L++R Y +G V +D ++
Sbjct: 398 HFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQD 457
Query: 549 VEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQF 370
+ IN+ LR + +VSQEP LF +I EN+ YG +V E+EKA++ ANA++F+ +
Sbjct: 458 IRTINVRFLREIIGVVSQEPVLFATTIAENIRYG-RENVTMDEIEKAVKEANAYDFIMKL 516
Query: 369 PQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTA 190
P DTLVGERGAQLSGGQKQRIAIARA++RNPK+LLLDEATSALD++SE VVQ ALD A
Sbjct: 517 PHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKA 576
Query: 189 SERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLV--QKQGIQVE 16
+ +T+V+AHRLSTV NAD IA +G + E+G H+EL++++ IY++LV Q G +VE
Sbjct: 577 RKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVE 636
>gi|2506118|sp|P08183|MDR1_HUMAN Multidrug resistance protein 1
(P-glycoprotein 1) (CD243 antigen)
gi|1070659|pir||DVHU1 multidrug resistance protein 1 - human
gi|386862|gb|AAA59576.1| P glycoprotein
Length = 1280
Score = 754 bits (1947), Expect = 0.0
Identities = 451/1253 (35%), Positives = 680/1253 (53%), Gaps = 54/1253 (4%)
Frame = -1
Query: 3627 EKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNA 3448
EKKP+ + +F+ S+ +K ++G L +++ G P M FGE++ + N
Sbjct: 29 EKKPTVS---VFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNL 85
Query: 3447 --INNKTIDPADLEKA--YEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTY 3280
+ + + +D+ + E M + +++ G + A +Q + +
Sbjct: 86 EDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIH 145
Query: 3279 RVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTA 3100
++RKQ+ +++++ +FD G L+T L D++ + E +KI + + F G
Sbjct: 146 KIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFI 205
Query: 3099 LAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVC 2920
+ F W+L + S + S + + + T K+ YA AG++A + L A +TV
Sbjct: 206 VGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVI 265
Query: 2919 SLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYSG- 2743
+ GQK E+ERY + L+ ++ GI++A+ +IS G + + + + G T++ SG
Sbjct: 266 AFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGE 325
Query: 2742 ------------------------------------TLETAVVVRDDNVIEKDETDYDVE 2671
E ++ + I+
Sbjct: 326 YSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKP 385
Query: 2670 VEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYN 2491
+ GN+ F+NV FSYP+R + ++LKG++ VQ+G+ +ALVG SG GKST VQL+ Y+
Sbjct: 386 DNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYD 445
Query: 2490 IDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALR 2311
G + +DG D+ +N++ LR +IGVVSQEPVLF TTI ENIR+G NV++ EI A++
Sbjct: 446 PTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVK 505
Query: 2310 KANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNES 2131
+ANAYDF+ P T+VGERG QLSGGQKQRIAIAR LVRNPKILLLDEATSALD ES
Sbjct: 506 EANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTES 565
Query: 2130 EQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDL 1951
E VVQ AL+ A +GRTTIV+AHRLST+RNA I G IVE GNHDEL+ ++G+Y L
Sbjct: 566 EAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKL 625
Query: 1950 VQAQLLESHDDHEELPPLAARQLSQELSPLH--------SYAIQRSTSNDA-GVHDDDME 1798
V Q + + E AA + E+ L S +RST G D +
Sbjct: 626 VTMQTAGNEVELEN----AADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRK 681
Query: 1797 RILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAM 1618
E E + I+K ++ + + VF + I G P A + + F
Sbjct: 682 LSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTR 741
Query: 1617 IG--EDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPC 1444
I E S+L++L F+ L + +T + Q + FGK E L+ RLR F ML
Sbjct: 742 IDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDV 801
Query: 1443 AFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEV 1264
+++DDP ++ L+ RL D++ VK A+ RL + + + I + +Y W++TL +
Sbjct: 802 SWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLL 861
Query: 1263 LMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLIS 1084
L P +D E + + A EA+EN RTV +L E K + +
Sbjct: 862 LAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTQEQKFEHMYA 921
Query: 1083 EHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTL 904
+ LQ +++ ++A I G + + F Y+ F+FG YL K ++ D LV +
Sbjct: 922 QSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAV 981
Query: 903 SMTANMAGSAAAYLPDYKKA-VHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGENVQ 727
A G +++ PDY KA + AA +I + P +S+ N +G + V
Sbjct: 982 VFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVV 1041
Query: 726 FHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENV 547
F+Y RPD +L G++L+V G+TLALVG SGCGKST++ LLERFY + G+V +D + +
Sbjct: 1042 FNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEI 1101
Query: 546 EDINLNHLRSNLALVSQEPTLFNCSIRENLLYG-LTRSVPQLELEKALQTANAFNFVFQF 370
+ +N+ LR++L +VSQEP LF+CSI EN+ YG +R V Q E+ +A + AN F+
Sbjct: 1102 KRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESL 1161
Query: 369 PQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTA 190
P T VG++G QLSGGQKQRIAIARA++R P +LLLDEATSALD++SEKVVQ ALD A
Sbjct: 1162 PNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKA 1221
Query: 189 SERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
E + +V+AHRLST+ NAD I V +NG+V E GTH++LL ++ IY+ +V Q
Sbjct: 1222 REGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ 1274
Score = 319 bits (817), Expect = 4e-85
Identities = 194/540 (35%), Positives = 298/540 (54%), Gaps = 3/540 (0%)
Frame = -1
Query: 1626 FAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLP 1447
F + EDM Y++ ++ + V Y Q ++ + + ++R + F ++
Sbjct: 104 FMNLEEDMTRYAYYYSGIGAGVLV----AAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQE 159
Query: 1446 CAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLE 1267
++D H L+ RL D S + + D++G ++ WK+TL
Sbjct: 160 IGWFDV--HDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLV 217
Query: 1266 VLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLI 1087
+L P ++ +A+ + A E L +RTV A + K +
Sbjct: 218 ILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERY 277
Query: 1086 SEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMT 907
+++L++ + K+AI + G + Y+++F +GT L L E + V +
Sbjct: 278 NKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFS 337
Query: 906 LSMTANMAGSAAAYLPDYKKAVHAAGLIFHLF-TYPATMPFSSSDGKKNIEKGEIIGENV 730
+ + A G A+ + + A AA IF + P+ +S S K + KG + NV
Sbjct: 338 VLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNV 397
Query: 729 QFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSEN 550
F Y R + IL G+NLKV G+T+ALVG SGCGKST + L++R Y +G V +D ++
Sbjct: 398 HFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQD 457
Query: 549 VEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQF 370
+ IN+ LR + +VSQEP LF +I EN+ YG +V E+EKA++ ANA++F+ +
Sbjct: 458 IRTINVRFLREIIGVVSQEPVLFATTIAENIRYG-RENVTMDEIEKAVKEANAYDFIMKL 516
Query: 369 PQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTA 190
P DTLVGERGAQLSGGQKQRIAIARA++RNPK+LLLDEATSALD++SE VVQ ALD A
Sbjct: 517 PHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKA 576
Query: 189 SERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLV--QKQGIQVE 16
+ +T+V+AHRLSTV NAD IA +G + E+G H+EL++++ IY++LV Q G +VE
Sbjct: 577 RKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVE 636
>gi|50732589|ref|XP_418707.1| PREDICTED: similar to ATP-binding
cassette, sub-family B (MDR/TAP), member 1A; multiple
drug resistant 1a [Gallus gallus]
Length = 1734
Score = 750 bits (1936), Expect = 0.0
Identities = 462/1263 (36%), Positives = 674/1263 (52%), Gaps = 81/1263 (6%)
Frame = -1
Query: 3588 VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEK 3409
+F+ + + L ++G++ + G P M FG+++ V + +N+ T + A +
Sbjct: 114 LFRYADWVDILLMVVGLIAAAANGTGLPLMIIIFGDMTNAFVL--SGVNSSTSEGASVNN 171
Query: 3408 AY------EEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLL 3247
+ + E M + +++ G A I +++Q T R+R+++ +L
Sbjct: 172 SSCQPAPGVDIEADMTKFAYYYVGIGFAVLILSTIQVWTFLIAATRQTSRIRRKFFFAVL 231
Query: 3246 KKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLAS 3067
++ +FDS G L+T L D++ E +KI + + F + F G + F W+L
Sbjct: 232 HQEMAWFDSTQIGTLNTRLTDDINTIHEGIGDKICIFVQFFSTFLAGITIGFAHGWKLTL 291
Query: 3066 YGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIER 2887
+ S +A S + S + T K+ + YA AG++A + L A +TV + NGQ+ + +
Sbjct: 292 VILSVSPLLAASAAVWSTLLASLTAKELSAYAKAGAVAEEVLTAIRTVVAFNGQQKALAK 351
Query: 2886 YTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYS------------- 2746
Y L+A G+++++ + S GV+ F + + G +
Sbjct: 352 YDTNLEAARHVGVKKSITTNTSLGVSQFLIFGSYALAFWYGTKLTVEEPENYDIGRVLIV 411
Query: 2745 --------------------------GTLETAVVVRDDNVIEKDETDYDVEVEVNGNISF 2644
E ++ +I+ + ++ G I F
Sbjct: 412 FFSVLIGAFSLGQAAPNLESVANARGAAYEVYQIINKKRLIDSSSKEGYKPDKLKGEIEF 471
Query: 2643 KNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFID 2464
+N+ FSYP+RPD +LKG++ VQ G+ IALVGASG GKST VQLL +Y+ D G + +D
Sbjct: 472 RNIHFSYPSRPDITILKGLNLKVQTGKTIALVGASGCGKSTTVQLLQRFYDPDQGEVTLD 531
Query: 2463 GMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVC 2284
G D+ +N+K LR IG+VSQEPVLF TTI ENIR+G ++S EI A ++ANA+DF+
Sbjct: 532 GRDIRTLNVKWLRENIGIVSQEPVLFATTIAENIRYGREDISDAEIEQAAKEANAFDFIS 591
Query: 2283 SFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALE 2104
P T+VGERG QLSGGQKQRIAIAR L RNPKILLLDEATSALD +SE VVQ AL+
Sbjct: 592 RLPDKFNTMVGERGAQLSGGQKQRIAIARALARNPKILLLDEATSALDTQSESVVQAALD 651
Query: 2103 NASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLV-------- 1948
A GRTTIV+AHRLSTIR A I +KG +VE G H EL+ ++GVY LV
Sbjct: 652 KARTGRTTIVIAHRLSTIRTADTIAAFEKGIVVEQGTHSELMLQKGVYYSLVMQQSGSNN 711
Query: 1947 -------------QAQLLESHD-----------DHEELPPLAARQLSQELSPLHSYAIQR 1840
+A+ E +D DH E P + R + S Y +R
Sbjct: 712 VQDDGTSEEDEETEAEEYEENDKSSSVEKLNLKDHFEEPVITGRGSIRRRS--SRYKSKR 769
Query: 1839 STSNDAGVHDDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPI 1660
S+S ++ EL +E I+ +P++ ++ + V +A+ G +P
Sbjct: 770 SSSK-----KKSSKKKKKELEEENLPAVPYTRILALNKPEWLYVLLGVIAAAVSGGVHPA 824
Query: 1659 LAQLIVRTYEGFAMIGEDMLYYSHL-WALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRL 1483
A + + F + + L +L F+ L V T Q + FGK E L+ RL
Sbjct: 825 FAVIFGKIIGAFQERDPERRNKNTLVLSLMFLLLGVITLATYIIQGFMFGKSGEILTMRL 884
Query: 1482 RIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAIT 1303
R SF +L +YDD ++ L RL TD+S VK A RLG + MTV + AI
Sbjct: 885 RSLSFKALLQQEIGWYDDQKNAVGVLLTRLATDASQVKGATGSRLGLMTMTVFTLLTAII 944
Query: 1302 TASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVR 1123
A +Y W++TL +L P +D A E + R + E++EN+RTV
Sbjct: 945 IAFVYGWQLTLLILACIPFVIAANAANVSSVSGHAAKDQKALEEAGRVSTESVENIRTVA 1004
Query: 1122 ALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKE 943
+L E+ L ++ K+A + G G++ S FV + F+FG +L R
Sbjct: 1005 SLTREEAFYEKYINSLNGPYRDSLKKAPLYGFTYGIAQSANYFVNAAVFRFGAWLIARCL 1064
Query: 942 VAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKK- 766
+ ++V ++ A G +A+ PDY KA +A IFHL + S +G+K
Sbjct: 1065 TNFENVFIVFSSVIFAAMNVGQSASLAPDYGKAKVSAQRIFHLLDRKPQIDSYSEEGEKL 1124
Query: 765 -NIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFY 589
N E G I N+ F Y RP+ +L G+N+KV+ G+TLALVG SGCGKST I LLERFY
Sbjct: 1125 SNFE-GNIEFRNIHFVYPTRPEVQVLQGLNVKVNKGQTLALVGSSGCGKSTSIQLLERFY 1183
Query: 588 HAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYG-LTRSVPQLELEK 412
V+G+V D + + ++L LRS L LVSQEP LF+CSI EN+ YG R V Q E+E+
Sbjct: 1184 DPVEGQVLADGFDTKSLHLQWLRSRLGLVSQEPILFDCSIAENIQYGDNNRLVSQEEIEE 1243
Query: 411 ALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALD 232
A + AN F+ + P+ +T VGE+G QLSGGQKQRIAIARA++RNP VLLLDEATSALD
Sbjct: 1244 AAKAANIHAFIDKLPEKYNTRVGEKGTQLSGGQKQRIAIARALVRNPAVLLLDEATSALD 1303
Query: 231 SDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIY 52
++SEK+VQ ALD A + + +V+AHRL+T+ NAD IAV++NG+V EQGTH +LL K Y
Sbjct: 1304 TESEKIVQKALDNARQGRTCIVIAHRLTTIQNADIIAVIQNGRVVEQGTHSQLLAKEGHY 1363
Query: 51 WRL 43
+ L
Sbjct: 1364 YAL 1366
Score = 322 bits (825), Expect = 4e-86
Identities = 193/504 (38%), Positives = 280/504 (55%), Gaps = 4/504 (0%)
Frame = -1
Query: 1530 QYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDR 1351
Q + F + + ++R+R K F +L A++D L+ RL D + + + D+
Sbjct: 207 QVWTFLIAATRQTSRIRRKFFFAVLHQEMAWFDSTQIGT--LNTRLTDDINTIHEGIGDK 264
Query: 1350 LGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFEN 1171
+ + IT + WK+TL +L P ++ A+
Sbjct: 265 ICIFVQFFSTFLAGITIGFAHGWKLTLVILSVSPLLAASAAVWSTLLASLTAKELSAYAK 324
Query: 1170 SNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFV 991
+ A E L +RTV A N + K ++ +L+ K++I + G+S
Sbjct: 325 AGAVAEEVLTAIRTVVAFNGQQKALAKYDTNLEAARHVGVKKSITTNTSLGVSQFLIFGS 384
Query: 990 YSVSFKFGTYLALRKEVAPMD---TYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIF 820
Y+++F +GT L + +E D +V ++ + A G AA L A AA ++
Sbjct: 385 YALAFWYGTKLTV-EEPENYDIGRVLIVFFSVLIGAFSLGQAAPNLESVANARGAAYEVY 443
Query: 819 HLFTYPATMPFSSSDGKKNIE-KGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALV 643
+ + SS +G K + KGEI N+ F Y RPD IL G+NLKV GKT+ALV
Sbjct: 444 QIINKKRLIDSSSKEGYKPDKLKGEIEFRNIHFSYPSRPDITILKGLNLKVQTGKTIALV 503
Query: 642 GPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRE 463
G SGCGKST + LL+RFY GEV +D ++ +N+ LR N+ +VSQEP LF +I E
Sbjct: 504 GASGCGKSTTVQLLQRFYDPDQGEVTLDGRDIRTLNVKWLRENIGIVSQEPVLFATTIAE 563
Query: 462 NLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAI 283
N+ YG + E+E+A + ANAF+F+ + P +T+VGERGAQLSGGQKQRIAIARA+
Sbjct: 564 NIRYG-REDISDAEIEQAAKEANAFDFISRLPDKFNTMVGERGAQLSGGQKQRIAIARAL 622
Query: 282 LRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGK 103
RNPK+LLLDEATSALD+ SE VVQ ALD A +T+V+AHRLST+ AD+IA + G
Sbjct: 623 ARNPKILLLDEATSALDTQSESVVQAALDKARTGRTTIVIAHRLSTIRTADTIAAFEKGI 682
Query: 102 VAEQGTHEELLRKRSIYWRLVQKQ 31
V EQGTH EL+ ++ +Y+ LV +Q
Sbjct: 683 VVEQGTHSELMLQKGVYYSLVMQQ 706
>gi|25297453|pir||D87789 protein C34G6.4 [imported] - Caenorhabditis
elegans
Length = 1289
Score = 748 bits (1932), Expect = 0.0
Identities = 452/1273 (35%), Positives = 693/1273 (53%), Gaps = 65/1273 (5%)
Frame = -1
Query: 3648 PLLPQSDEKKPSQICSFIRV----VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGE 3481
PLL +S S S +++ +F + + L + G + +++ G P ++ G
Sbjct: 14 PLLKRSHSSDSSIDESTVKLTNYGIFYYTQGVDLLLLITGTVAAVIHGAGFPLLAIVLGG 73
Query: 3480 VSQVLVTITNA---INNKTIDPADLEK-AYEEYERGMNQVVFHFFLCGCAYFIFASLQHA 3313
++ V + N+ + ++P L + +E+ + + ++ + G F + +Q A
Sbjct: 74 MTTVFLRAQNSDFVVGVDNVNPEGLVPISLDEFNSEVVKYCIYYLVLGVLMFFTSYVQIA 133
Query: 3312 IMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALII 3133
+ + +++R+ Y+ +L++ Q+FD TG+L+ L D+LER RE +K AL++
Sbjct: 134 CFESYAERLVHKLRQNYLKAILRQQIQWFDKQQTGNLTARLTDDLERVREGLGDKFALLV 193
Query: 3132 AFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIA 2953
F G + F+ W + + F+ I SG S + T + YA AG+IA
Sbjct: 194 QMFAAFLAGYGVGFFYSWSMTLVMMGFAPLIVLSGAKMSKSMATRTRVEQETYAVAGAIA 253
Query: 2952 FQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVL 2773
+T + +TV SLNG K E++R+ L+ G + GI + I G + S +
Sbjct: 254 EETFSSIRTVHSLNGHKRELDRFYNALEVGRQTGIVKYCYMGIGVGFSNLCMYSSYALAF 313
Query: 2772 YVGATMIYS---------------------------------GTLETAV-----VVRDDN 2707
+ G+T+I + GT A V+
Sbjct: 314 WYGSTLIINDPTFDRGLIFTVFFAVLSGSTSLGGALPHLASFGTARGAASTVLRVINSHP 373
Query: 2706 VIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGK 2527
I+ + + + G+ISFK+V F YP+R D VLKGIS +++ G+ IALVG+SG GK
Sbjct: 374 KIDPYSLEGILVDNMKGDISFKDVHFRYPSRKDIHVLKGISLELKAGDKIALVGSSGCGK 433
Query: 2526 STVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNP 2347
ST+V LL +Y+ G + IDG+DL ++N+ LR IG+VSQEPVLF+ TI ENI+ GN
Sbjct: 434 STIVNLLQRFYDPTKGRVLIDGVDLREVNVHSLREQIGIVSQEPVLFDGTIYENIKMGNE 493
Query: 2346 NVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILL 2167
+ + ++ A + ANA DF+ P G T VGE+G QLSGGQKQRIAIAR LV+NPKILL
Sbjct: 494 HATHDQVVEACKMANANDFIKRLPDGYGTRVGEKGVQLSGGQKQRIAIARALVKNPKILL 553
Query: 2166 LDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHD 1987
LDEATSALD E+E+ VQ AL+ A GRTTI+VAHRLSTIRN +I V + G IVE G+H+
Sbjct: 554 LDEATSALDTEAEREVQGALDQAQAGRTTIIVAHRLSTIRNVDRIFVFKAGNIVESGSHE 613
Query: 1986 ELIAKRGVYNDLVQAQLLESH------DDHEELPPLAARQLSQELSPLHSYAIQRSTSND 1825
EL++K+G++ D+ QAQ++ D + + A LS++ S + +I S
Sbjct: 614 ELMSKQGIFYDMTQAQVVRQQQQEAGKDIEDTISESAHSHLSRKSSTRSAISIATSIHQL 673
Query: 1824 A----------GVHDDDM--ERILDELSKE-GAKKSNLREIVKQCRPDYCFLFIAVFGSA 1684
A G + D+ RIL E A +++ +I K + +FG+
Sbjct: 674 AEEVELIDPFNGQTNQDVIRSRILSAFGGECKAPPTSMFKIFKFNGDKVGWFIGGIFGAF 733
Query: 1683 IQGVSYPILAQLIVRTYEGFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVS 1504
I G P+ A + + +++ + M + W F+ + + + + G+
Sbjct: 734 IFGSVTPVFALVYAEIFNVYSLPADQMQANVYFWCGMFVLMGITFFVGFFTSANCLGRCG 793
Query: 1503 EQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVV 1324
E L+ +LR ++F ++L AFYDD H +L R TD+ NV+ V RL V+ ++V
Sbjct: 794 ESLTMKLRFEAFKNLLRQDIAFYDDLRHGTGKLCTRFATDAPNVRY-VFTRLPVVLASIV 852
Query: 1323 AISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEAL 1144
I A+ Y W++ L +++ P DT E + + A +A+
Sbjct: 853 TICGALGIGFYYGWQLALILVVMVPLLVMGGYFEMQMRFGKQIRDTQLLEEAGKVASQAV 912
Query: 1143 ENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGT 964
E++RTV +LN +++ E+L++ + K A GA S S F+Y+ +F G+
Sbjct: 913 EHIRTVHSLNRQEQFHFTYCEYLREPFNTNLKHAHTYGAVFAFSQSLIFFMYAAAFYLGS 972
Query: 963 YLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFS 784
++ + P+D Y V +S M G+ +++PD KA AA L+F+L +P +
Sbjct: 973 IFVNQQAMQPIDVYRVFFAISFCGQMIGNTTSFIPDVVKARLAASLLFYLIEHPTPIDSL 1032
Query: 783 SSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISL 604
S G G I NV F+Y R D +L G L + GKT+ALVG SGCGKSTI+ L
Sbjct: 1033 SDSGIVKPITGNISIRNVFFNYPTRKDTKVLQGFTLDIKAGKTVALVGHSGCGKSTIMGL 1092
Query: 603 LERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQL 424
LERFY+ G + ID +N+ ++N++ LR + +VSQEPTLF+C+I EN+ YG R+V
Sbjct: 1093 LERFYNQDKGMIMIDGDNIRNLNISSLREQVCIVSQEPTLFDCTIGENICYGTNRNVTYQ 1152
Query: 423 ELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEAT 244
E+ +A + AN NF+ P G DT VGE+G QLSGGQKQRIAIARA++R+P VLLLDEAT
Sbjct: 1153 EIVEAAKMANIHNFILGLPDGYDTHVGEKGTQLSGGQKQRIAIARALVRSPSVLLLDEAT 1212
Query: 243 SALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRK 64
SALD++SEK+VQ ALD A + + +V+AHRLST+ N+D IA++ GK+ E+GTH+EL+RK
Sbjct: 1213 SALDTESEKIVQEALDAAKQGRTCLVIAHRLSTIQNSDVIAIVSEGKIVEKGTHDELIRK 1272
Query: 63 RSIYWRLVQKQGI 25
IY + + Q I
Sbjct: 1273 SEIYQKFCETQRI 1285
Score = 286 bits (733), Expect = 2e-75
Identities = 184/590 (31%), Positives = 291/590 (49%), Gaps = 23/590 (3%)
Frame = -1
Query: 1722 DYCFLFIAVFGSAIQGVSYPILAQLI-------VRTYEGFAMIGEDMLYYSHLWALS--- 1573
D L + I G +P+LA ++ +R ++G D + L +S
Sbjct: 46 DLLLLITGTVAAVIHGAGFPLLAIVLGGMTTVFLRAQNSDFVVGVDNVNPEGLVPISLDE 105
Query: 1572 -----------FMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDP 1426
++ L V T Y Q F +E+L +LR +L ++D
Sbjct: 106 FNSEVVKYCIYYLVLGVLMFFTSYVQIACFESYAERLVHKLRQNYLKAILRQQIQWFD-- 163
Query: 1425 NHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPX 1246
L+ RL D V+ + D+ ++ A Y W MTL ++ F P
Sbjct: 164 KQQTGNLTARLTDDLERVREGLGDKFALLVQMFAAFLAGYGVGFFYSWSMTLVMMGFAPL 223
Query: 1245 XXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKI 1066
+ + + + A E ++RTV +LN + + L+
Sbjct: 224 IVLSGAKMSKSMATRTRVEQETYAVAGAIAEETFSSIRTVHSLNGHKRELDRFYNALEVG 283
Query: 1065 HKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDT-YLVLMTLSMTAN 889
++ + G G S C Y+++F +G+ L + + V + +
Sbjct: 284 RQTGIVKYCYMGIGVGFSNLCMYSSYALAFWYGSTLIINDPTFDRGLIFTVFFAVLSGST 343
Query: 888 MAGSAAAYLPDYKKAVHAAGLIFHLF-TYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQ 712
G A +L + A AA + + ++P P+S + KG+I ++V F Y
Sbjct: 344 SLGGALPHLASFGTARGAASTVLRVINSHPKIDPYSLEGILVDNMKGDISFKDVHFRYPS 403
Query: 711 RPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINL 532
R D +L G++L++ G +ALVG SGCGKSTI++LL+RFY G V ID ++ ++N+
Sbjct: 404 RKDIHVLKGISLELKAGDKIALVGSSGCGKSTIVNLLQRFYDPTKGRVLIDGVDLREVNV 463
Query: 531 NHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDT 352
+ LR + +VSQEP LF+ +I EN+ G + +E A + ANA +F+ + P G T
Sbjct: 464 HSLREQIGIVSQEPVLFDGTIYENIKMGNEHATHDQVVE-ACKMANANDFIKRLPDGYGT 522
Query: 351 LVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLST 172
VGE+G QLSGGQKQRIAIARA+++NPK+LLLDEATSALD+++E+ VQ ALD A +T
Sbjct: 523 RVGEKGVQLSGGQKQRIAIARALVKNPKILLLDEATSALDTEAEREVQGALDQAQAGRTT 582
Query: 171 VVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQ 22
++VAHRLST+ N D I V K G + E G+HEEL+ K+ I++ + Q Q ++
Sbjct: 583 IIVAHRLSTIRNVDRIFVFKAGNIVESGSHEELMSKQGIFYDMTQAQVVR 632
>gi|25453370|ref|NP_036755.2| P-glycoprotein/multidrug resistance 1;
ATP-binding cassette, sub-family B (MDR/TAP), member 1
(P-glycoprotein/multidrug resistance 1); ATP-binding
cassette sub-family B (MDR/TAP) member 1
(P-glycoprotein/multidrug resistance 1) [Rattus
norvegicus]
gi|19743730|gb|AAL92458.1| ATP-binding cassette protein B1b [Rattus
norvegicus]
Length = 1275
Score = 748 bits (1931), Expect = 0.0
Identities = 457/1258 (36%), Positives = 703/1258 (55%), Gaps = 61/1258 (4%)
Frame = -1
Query: 3627 EKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVS--------Q 3472
EKKP+ I +F+ + +K LG L +++ G P + FG ++ +
Sbjct: 27 EKKPAV---GIFGMFRYADWLDKLCMALGTLAAIIHGTLLPLLMLVFGYMTDSFTQAETR 83
Query: 3471 VLVTITNA--INN-KTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKY 3301
+L ++TN IN+ +T+ + LE+ Y +++ G I A +Q ++
Sbjct: 84 ILPSVTNQSEINSTQTVSDSSLEEDMAMY-------AYYYTGIGAGVLIVAYIQVSLWCL 136
Query: 3300 VGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVT 3121
+++R+++ ++ ++ +FD G L+T L D++ + + +K+ + +T
Sbjct: 137 AAGRQIHKIRQKFFHAIMNQEIGWFDVNDAGELNTRLTDDVSKINDGIGDKLGMFFQSIT 196
Query: 3120 DFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTL 2941
F+ G + F + W+L + S I S + + + T K+ YA AG++A + L
Sbjct: 197 TFSAGFIIGFISGWKLTLVILAVSPLIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEVL 256
Query: 2940 GAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGA 2761
A +TV + GQK E+ERY + L+ ++ GI++A+ +IS G+ Y + + + G
Sbjct: 257 AAIRTVIAFGGQKKELERYNKNLEEAKRVGIKKAITANISIGIAYLLVYASYALAFWYGT 316
Query: 2760 TMIYS-----------------GTL--------------------ETAVVVRDDNVIEKD 2692
+++ S GT E ++ ++ I+
Sbjct: 317 SLVLSNEYSIGQVLTVFFSILLGTFSIGHLAPNIEAFANARGAAYEIFKIIDNEPSIDSF 376
Query: 2691 ETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQ 2512
T + GN+ FKNV F+YP+R + ++LKG++ V++G+ +ALVG SG GKST VQ
Sbjct: 377 STKGHKPDSIMGNLEFKNVYFNYPSRSEVKILKGLNLKVKSGQTVALVGNSGCGKSTTVQ 436
Query: 2511 LLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLP 2332
LL Y+ G + IDG D+ +N++ LR +IGVVSQEPVLF TTI ENIR+G NV++
Sbjct: 437 LLQRLYDPIEGEVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMD 496
Query: 2331 EIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEAT 2152
EI A+++ANAYDF+ P T+VGERG QLSGGQKQRIAIAR LVRNPKILLLDEAT
Sbjct: 497 EIEKAVKEANAYDFIMKLPHKFNTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEAT 556
Query: 2151 SALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAK 1972
SALD ESE VVQ AL+ A +GRTTIV+AHRLST+RNA I G IVE GNH+EL+ +
Sbjct: 557 SALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEELMKE 616
Query: 1971 RGVYNDLVQAQ-----LLESHDDHEELPPLAARQLSQE--LSPLHSYAIQRSTSNDAGVH 1813
+G+Y LV Q + ++ +E A +L+ E SPL +I+RS
Sbjct: 617 KGIYFKLVMTQTRGNEIEPGNNAYESQSDTGASELTSEKSKSPLIRRSIRRSIH-----R 671
Query: 1812 DDDMERILD--ELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVR 1639
D ER L E E + +I+K ++ +L + V + I G P+ A + +
Sbjct: 672 RQDQERRLSSKEDVDEDVPMVSFWQILKLNISEWPYLVVGVLCAVINGCIQPVFAIVFSK 731
Query: 1638 TYEGFAMIG--EDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFS 1465
F+ E +L++L F+ + + +T + Q + FGK E L+ RLR F
Sbjct: 732 IVGVFSRDDDHETKQRNCNLFSLLFLVMGMISFVTYFFQGFAFGKAGEILTKRLRYMVFK 791
Query: 1464 HMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYC 1285
ML +++DD ++ L+ RL +D+SNVK A+ RL V V + I + +Y
Sbjct: 792 SMLRQDISWFDDHKNTTGSLTTRLASDASNVKGAMGSRLAVVTQNVANLGTGIILSLVYG 851
Query: 1284 WKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLED 1105
W++TL +++ P +D E S + A EA+EN RTV +L E
Sbjct: 852 WQLTLLLVVIIPLIVLGGIIEMKLLSGQALKDKKELEISGKIATEAIENFRTVVSLTREQ 911
Query: 1104 KIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDT 925
K ++ ++ LQ +++ K+A + G + + F Y+ F+FG YL R+ + +
Sbjct: 912 KFETMYAQSLQIPYRNALKKAHVFGITFAFTQAMIYFSYAACFRFGAYLVARELMTFENV 971
Query: 924 YLVLMTLSMTANMAGSAAAYLPDYKKA-VHAAGLIFHLFTYPATMPFSSSDGKKNIEKGE 748
LV + A AG+ +++ PDY KA V A+ +I + P +S+ K N +G
Sbjct: 972 MLVFSAVVFGAMAAGNTSSFAPDYAKAKVSASHIIRIIEKIPEIDSYSTEGLKPNWLEGN 1031
Query: 747 IIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEV 568
+ V F+Y RP+ +L G++ +V G+TLALVG SGCGKST++ LLERFY+ + G V
Sbjct: 1032 VKFNGVMFNYPTRPNIPVLQGLSFEVKKGQTLALVGSSGCGKSTVVQLLERFYNPMAGTV 1091
Query: 567 KIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYG-LTRSVPQLELEKALQTANA 391
+D + ++ +N+ LR++L +VSQEP LF+CSI EN+ YG +R V E+ +A + AN
Sbjct: 1092 FLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSITENIAYGDNSRVVSHEEIVRAAREANI 1151
Query: 390 FNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVV 211
F+ P+ +T VG++G QLSGGQKQRIAIARA++R P +LLLDEATSALD++SEKVV
Sbjct: 1152 HQFIDSLPEKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVV 1211
Query: 210 QNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQ 37
Q ALD A E + +V+AHRLST+ NAD I V++NG+V E GTH++LL ++ IY+ +VQ
Sbjct: 1212 QEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGQVKEHGTHQQLLAQKGIYFSMVQ 1269
Score = 327 bits (837), Expect = 2e-87
Identities = 191/494 (38%), Positives = 286/494 (57%), Gaps = 3/494 (0%)
Frame = -1
Query: 1488 RLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIA 1309
++R K F +++ ++D + A L+ RL D S + + D+LG ++ S
Sbjct: 144 KIRQKFFHAIMNQEIGWFDV--NDAGELNTRLTDDVSKINDGIGDKLGMFFQSITTFSAG 201
Query: 1308 ITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRT 1129
+ WK+TL +L P ++ A+ + A E L +RT
Sbjct: 202 FIIGFISGWKLTLVILAVSPLIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRT 261
Query: 1128 VRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALR 949
V A + K + +++L++ + K+AI + G++ Y+++F +GT L L
Sbjct: 262 VIAFGGQKKELERYNKNLEEAKRVGIKKAITANISIGIAYLLVYASYALAFWYGTSLVLS 321
Query: 948 KEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLF-TYPATMPFSSSDG 772
E + V ++ + G A + + A AA IF + P+ FS+
Sbjct: 322 NEYSIGQVLTVFFSILLGTFSIGHLAPNIEAFANARGAAYEIFKIIDNEPSIDSFSTKGH 381
Query: 771 KKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERF 592
K + G + +NV F+Y R + IL G+NLKV G+T+ALVG SGCGKST + LL+R
Sbjct: 382 KPDSIMGNLEFKNVYFNYPSRSEVKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRL 441
Query: 591 YHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEK 412
Y ++GEV ID +++ IN+ +LR + +VSQEP LF +I EN+ YG +V E+EK
Sbjct: 442 YDPIEGEVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYG-RENVTMDEIEK 500
Query: 411 ALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALD 232
A++ ANA++F+ + P +TLVGERGAQLSGGQKQRIAIARA++RNPK+LLLDEATSALD
Sbjct: 501 AVKEANAYDFIMKLPHKFNTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALD 560
Query: 231 SDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIY 52
++SE VVQ ALD A E +T+V+AHRLSTV NAD IA G + EQG HEEL++++ IY
Sbjct: 561 TESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEELMKEKGIY 620
Query: 51 WRLV--QKQGIQVE 16
++LV Q +G ++E
Sbjct: 621 FKLVMTQTRGNEIE 634
Score = 309 bits (791), Expect = 4e-82
Identities = 193/577 (33%), Positives = 301/577 (51%), Gaps = 41/577 (7%)
Frame = -1
Query: 3549 LLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQVV 3370
++GVL +++ G QP + F ++ V + +E +R N
Sbjct: 709 VVGVLCAVINGCIQPVFAIVFSKIVGVF---------------SRDDDHETKQRNCNLFS 753
Query: 3369 FHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSV--STGHLST 3196
F + G F+ Q G+ T R+R +L++D +FD +TG L+T
Sbjct: 754 LLFLVMGMISFVTYFFQGFAFGKAGEILTKRLRYMVFKSMLRQDISWFDDHKNTTGSLTT 813
Query: 3195 VLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINS 3016
L + + ++A++ V + G L+ W+L + I G I
Sbjct: 814 RLASDASNVKGAMGSRLAVVTQNVANLGTGIILSLVYGWQLTLLLVVIIPLIVLGGIIEM 873
Query: 3015 AGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRAL 2836
+ K +G IA + + ++TV SL ++ Y + L+ + +++A
Sbjct: 874 KLLSGQALKDKKELEISGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNALKKAH 933
Query: 2835 MYSISRGVT-------YFFCNSLNTVVL------YVGATMIYSGTLETAVVVRDDNVIEK 2695
++ I+ T Y C ++ + +++S + A+ + +
Sbjct: 934 VFGITFAFTQAMIYFSYAACFRFGAYLVARELMTFENVMLVFSAVVFGAMAAGNTSSFAP 993
Query: 2694 DETDYDVEVE------------------------VNGNISFKNVKFSYPTRPDAQVLKGI 2587
D V + GN+ F V F+YPTRP+ VL+G+
Sbjct: 994 DYAKAKVSASHIIRIIEKIPEIDSYSTEGLKPNWLEGNVKFNGVMFNYPTRPNIPVLQGL 1053
Query: 2586 SFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVV 2407
SF+V+ G+ +ALVG+SG GKSTVVQLL +YN +G +F+DG ++ +N++ LR +G+V
Sbjct: 1054 SFEVKKGQTLALVGSSGCGKSTVVQLLERFYNPMAGTVFLDGKEIKQLNVQWLRAHLGIV 1113
Query: 2406 SQEPVLFNTTIEENIRFGNPN--VSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQL 2233
SQEP+LF+ +I ENI +G+ + VS EI A R+AN + F+ S P+ T VG++GTQL
Sbjct: 1114 SQEPILFDCSITENIAYGDNSRVVSHEEIVRAAREANIHQFIDSLPEKYNTRVGDKGTQL 1173
Query: 2232 SGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLST 2053
SGGQKQRIAIAR LVR P ILLLDEATSALD ESE+VVQ+AL+ A +GRT IV+AHRLST
Sbjct: 1174 SGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLST 1233
Query: 2052 IRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQA 1942
I+NA I+V+Q G++ E G H +L+A++G+Y +VQA
Sbjct: 1234 IQNADLIVVIQNGQVKEHGTHQQLLAQKGIYFSMVQA 1270
>gi|38073917|ref|XP_283101.2| similar to multidrug resistance
p-glycoprotein [Mus musculus]
Length = 1214
Score = 748 bits (1930), Expect = 0.0
Identities = 446/1158 (38%), Positives = 645/1158 (55%), Gaps = 46/1158 (3%)
Frame = -1
Query: 3375 VVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLST 3196
+ ++ G A IF +Q + T R+RKQ+ +L +D +FD L+T
Sbjct: 66 LTLYYIGIGAAALIFGYVQISFWVITAARQTTRIRKQFFHSILAQDISWFDGSDICELNT 125
Query: 3195 VLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINS 3016
+ ++ + + +KI L+ ++ F++G ++ W+L+ + S I S + S
Sbjct: 126 RMTGDINKLCDGIGDKIPLMFQNISGFSIGLVISLIKSWKLSLVVLSTSPLIMASSALCS 185
Query: 3015 AGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRAL 2836
++ T K+ Y+ AG++A + L + +TV + Q+ EI+RYT+ LK + GI+RA
Sbjct: 186 RMIISLTSKELDAYSKAGAVAEEALSSIQTVTAFGAQEKEIQRYTQHLKDAKDAGIKRAT 245
Query: 2835 MYSISRGVTYFFCNSLNTVVLYVGATMIYSGT---------------------------- 2740
+S G YFF N + + G ++I+ G
Sbjct: 246 ASKLSLGAVYFFMNGAYGLAFWYGTSLIFGGEPGYTIGTILAVFFSVIHSSYCIGSVAPH 305
Query: 2739 LETAVVVRDD-----NVIEKD------ETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLK 2593
LET V R VI+K T V + GNI FKNV FSYP+RP A+VLK
Sbjct: 306 LETFTVARGAAFNIFQVIDKKPNIDNFSTAGFVPECIEGNIEFKNVSFSYPSRPSAKVLK 365
Query: 2592 GISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIG 2413
G++ ++ GE +ALVG SGSGKST VQLL Y+ + G I +D D+ N++ R IG
Sbjct: 366 GLNLKIKAGETVALVGPSGSGKSTTVQLLQRLYDPEDGCITVDENDIRAQNVRHYREQIG 425
Query: 2412 VVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQL 2233
VV QEPVLF TTI NI+FG V E+ A R+ANAYDF+ +FPK T+VGE+G Q+
Sbjct: 426 VVRQEPVLFGTTIGNNIKFGREGVGEKEMEQAAREANAYDFIMAFPKKFNTLVGEKGAQM 485
Query: 2232 SGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLST 2053
SGGQKQRIAIAR LVRNPKIL+LDEATSALD ESE +VQ ALE AS+GRTTIVVAHRLST
Sbjct: 486 SGGQKQRIAIARALVRNPKILILDEATSALDTESESLVQTALEKASKGRTTIVVAHRLST 545
Query: 2052 IRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLESHDDHEELPPLAARQLSQE 1873
IR A I+ M+ G +VE G H EL+AK+G+Y L AQ ++ D+ E +R S
Sbjct: 546 IRGADLIVTMKDGMVVEKGTHAELMAKQGLYYSLAMAQDIKKVDEQME-----SRTCSTA 600
Query: 1872 LSPLHSYAIQRSTSNDAGVHDDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVF 1693
+ SY ++ D +E + K + +L +I K + ++ F+ +
Sbjct: 601 GNA--SYGSLCDVNSAKAPCTDQLEEAVHH-QKTSLPEVSLLKIFKLSKSEWPFVVLGTL 657
Query: 1692 GSAIQGVSYPILAQLIVRTYEGF-----AMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQ 1528
SA+ G +P+ + + + F A + +D + L+++ + L + +T Q
Sbjct: 658 ASALNGSVHPVFSIIFGKLVTMFEDKNKATLKQD----AELYSMMLVVLGIVALVTYLMQ 713
Query: 1527 YYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRL 1348
++G+ E L+ RLR +F ML A+YDD ++ L+ L D + ++ A RL
Sbjct: 714 GLFYGRAEENLAMRLRHSAFKAMLYQDMAWYDDKENNTGALTTTLAVDVAQIQGAATSRL 773
Query: 1347 GCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENS 1168
G V V +S++I + +Y W+MTL +L F P D A + +
Sbjct: 774 GIVTQDVSNMSLSILISFIYGWEMTLLILSFAPVLAVTGMIQTAAMAGFANRDKQALKRA 833
Query: 1167 NRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVY 988
+ A EA+EN+RTV +L E + E LQ H++ KRA I G +S + F +
Sbjct: 834 GKIATEAVENIRTVVSLTRERAFEQMYEETLQTQHRNALKRAHITGCCYAVSHAFVHFAH 893
Query: 987 SVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFT 808
+ F+FG YL + P ++V ++ A G + P+Y KA A +F L
Sbjct: 894 AAGFRFGAYLIQAGRMMPEGMFIVFTAIAYGAMAIGETLVWAPEYSKAKAGASHLFALLK 953
Query: 807 YPATMPFSSSDGKK-NIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSG 631
T+ S G+K + +G + V F Y RP+ +L ++L ++ GKT+A VG SG
Sbjct: 954 NKPTINSCSQSGEKPDTCEGNLEFREVSFVYPCRPEVPVLQNMSLSIEKGKTVAFVGSSG 1013
Query: 630 CGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLY 451
CGKST + LL+RFY + G+V +D +V+++N+ LRS A+VSQEP LFNCSI EN+ Y
Sbjct: 1014 CGKSTCVQLLQRFYDPMKGQVLLDGVDVKELNVQWLRSQTAIVSQEPVLFNCSIAENIAY 1073
Query: 450 G-LTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRN 274
G +R VP E+++ AN +F+ P+ +TLVG RG QLSGGQKQR+AIARA+LR
Sbjct: 1074 GDNSRMVPLEEIKEVADAANIHSFIEGLPRKYNTLVGLRGVQLSGGQKQRLAIARALLRK 1133
Query: 273 PKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAE 94
PK+LLLDEATSALD++SEKVVQ ALD A + +VVAHRLST+ NAD I VL+NG + E
Sbjct: 1134 PKILLLDEATSALDNESEKVVQQALDKARRGKTCLVVAHRLSTIQNADMIVVLQNGSIKE 1193
Query: 93 QGTHEELLRKRSIYWRLV 40
QGTH+ELLR Y++LV
Sbjct: 1194 QGTHQELLRNGDTYFKLV 1211
Score = 307 bits (787), Expect = 1e-81
Identities = 192/545 (35%), Positives = 301/545 (55%), Gaps = 12/545 (2%)
Frame = -1
Query: 1620 MIGEDM-----LYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHML 1456
M G D+ LYY + A + +F Y Q ++ + + +TR+R + F +L
Sbjct: 57 MTGTDLKGGLTLYYIGIGAAALIFG--------YVQISFWVITAARQTTRIRKQFFHSIL 108
Query: 1455 SLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKM 1276
+ +++D + L+ R+ D + + + D++ + + SI + + + WK+
Sbjct: 109 AQDISWFDGSD--ICELNTRMTGDINKLCDGIGDKIPLMFQNISGFSIGLVISLIKSWKL 166
Query: 1275 TLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIM 1096
+L VL P ++ A+ + A EAL +++TV A ++K +
Sbjct: 167 SLVVLSTSPLIMASSALCSRMIISLTSKELDAYSKAGAVAEEALSSIQTVTAFGAQEKEI 226
Query: 1095 SLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLF----VYSVSFKFGTYLALRKEVA-PM 931
++HL+ + KRA A+ LSL F Y ++F +GT L E +
Sbjct: 227 QRYTQHLKDAKDAGIKRA----TASKLSLGAVYFFMNGAYGLAFWYGTSLIFGGEPGYTI 282
Query: 930 DTYL-VLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTY-PATMPFSSSDGKKNIE 757
T L V ++ ++ GS A +L + A AA IF + P FS++
Sbjct: 283 GTILAVFFSVIHSSYCIGSVAPHLETFTVARGAAFNIFQVIDKKPNIDNFSTAGFVPECI 342
Query: 756 KGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVD 577
+G I +NV F Y RP +L G+NLK+ G+T+ALVGPSG GKST + LL+R Y D
Sbjct: 343 EGNIEFKNVSFSYPSRPSAKVLKGLNLKIKAGETVALVGPSGSGKSTTVQLLQRLYDPED 402
Query: 576 GEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTA 397
G + +D ++ N+ H R + +V QEP LF +I N+ +G V + E+E+A + A
Sbjct: 403 GCITVDENDIRAQNVRHYREQIGVVRQEPVLFGTTIGNNIKFG-REGVGEKEMEQAAREA 461
Query: 396 NAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEK 217
NA++F+ FP+ +TLVGE+GAQ+SGGQKQRIAIARA++RNPK+L+LDEATSALD++SE
Sbjct: 462 NAYDFIMAFPKKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDTESES 521
Query: 216 VVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQ 37
+VQ AL+ AS+ +T+VVAHRLST+ AD I +K+G V E+GTH EL+ K+ +Y+ L
Sbjct: 522 LVQTALEKASKGRTTIVVAHRLSTIRGADLIVTMKDGMVVEKGTHAELMAKQGLYYSLAM 581
Query: 36 KQGIQ 22
Q I+
Sbjct: 582 AQDIK 586
Score = 291 bits (745), Expect = 8e-77
Identities = 203/619 (32%), Positives = 308/619 (48%), Gaps = 45/619 (7%)
Frame = -1
Query: 3663 NNFSTPLLPQSDEKKPSQICSFIRV----VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMS 3496
N+ P Q +E Q S V +FK S F+ +LG L S + G P S
Sbjct: 612 NSAKAPCTDQLEEAVHHQKTSLPEVSLLKIFKLSKSEWPFV-VLGTLASALNGSVHPVFS 670
Query: 3495 YTFGEVSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQH 3316
FG+ LVT+ N T L++ E Y M VV G + +Q
Sbjct: 671 IIFGK----LVTMFEDKNKAT-----LKQDAELYS--MMLVVL-----GIVALVTYLMQG 714
Query: 3315 AIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSV--STGHLSTVLNDNLERFREVFNEKIA 3142
+N R+R +L +D ++D +TG L+T L ++ + + ++
Sbjct: 715 LFYGRAEENLAMRLRHSAFKAMLYQDMAWYDDKENNTGALTTTLAVDVAQIQGAATSRLG 774
Query: 3141 LIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAG 2962
++ V++ +L ++F W + + F+ +A +G I +A + + AG
Sbjct: 775 IVTQDVSNMSLSILISFIYGWEMTLLILSFAPVLAVTGMIQTAAMAGFANRDKQALKRAG 834
Query: 2961 SIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNT 2782
IA + + +TV SL ++ + Y E L+ + ++RA + V++ F + +
Sbjct: 835 KIATEAVENIRTVVSLTRERAFEQMYEETLQTQHRNALKRAHITGCCYAVSHAFVHFAHA 894
Query: 2781 VVLYVGATMIYSGTL--------------------ETAV-----------------VVRD 2713
GA +I +G + ET V ++++
Sbjct: 895 AGFRFGAYLIQAGRMMPEGMFIVFTAIAYGAMAIGETLVWAPEYSKAKAGASHLFALLKN 954
Query: 2712 DNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGS 2533
I + GN+ F+ V F YP RP+ VL+ +S ++ G+ +A VG+SG
Sbjct: 955 KPTINSCSQSGEKPDTCEGNLEFREVSFVYPCRPEVPVLQNMSLSIEKGKTVAFVGSSGC 1014
Query: 2532 GKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFG 2353
GKST VQLL +Y+ G + +DG+D+ ++N++ LR +VSQEPVLFN +I ENI +G
Sbjct: 1015 GKSTCVQLLQRFYDPMKGQVLLDGVDVKELNVQWLRSQTAIVSQEPVLFNCSIAENIAYG 1074
Query: 2352 NPN--VSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNP 2179
+ + V L EI AN + F+ P+ T+VG RG QLSGGQKQR+AIAR L+R P
Sbjct: 1075 DNSRMVPLEEIKEVADAANIHSFIEGLPRKYNTLVGLRGVQLSGGQKQRLAIARALLRKP 1134
Query: 2178 KILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEV 1999
KILLLDEATSALDNESE+VVQ+AL+ A +G+T +VVAHRLSTI+NA I+V+Q G I E
Sbjct: 1135 KILLLDEATSALDNESEKVVQQALDKARRGKTCLVVAHRLSTIQNADMIVVLQNGSIKEQ 1194
Query: 1998 GNHDELIAKRGVYNDLVQA 1942
G H EL+ Y LV A
Sbjct: 1195 GTHQELLRNGDTYFKLVAA 1213
>gi|6755046|ref|NP_035205.1| ATP-binding cassette, sub-family B
(MDR/TAP), member 1B; P glycoprotein 1 [Mus musculus]
gi|126927|sp|P06795|MDR1_MOUSE Multidrug resistance protein 1
(P-glycoprotein 1)
gi|72474|pir||DVMS1 multidrug resistance protein 1 - mouse
gi|387426|gb|AAA79005.1| multidrug resistance protein
Length = 1276
Score = 747 bits (1929), Expect = 0.0
Identities = 448/1260 (35%), Positives = 692/1260 (54%), Gaps = 52/1260 (4%)
Frame = -1
Query: 3660 NFSTPLLPQSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGE 3481
NFS EKK + + +F+ + +K +LG L +++ G P + FG
Sbjct: 14 NFSKMGKKSKKEKKEKKPAVGVFGMFRYADWLDKLCMILGTLAAIIHGTLLPLLMLVFGN 73
Query: 3480 VSQVLV----TITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHA 3313
++ +I +I N++ + L + E M +++ G I A +Q +
Sbjct: 74 MTDSFTKAEASILPSITNQSGPNSTLIISNSSLEEEMAIYAYYYTGIGAGVLIVAYIQVS 133
Query: 3312 IMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALII 3133
+ +++R+++ ++ ++ +FD G L+T L D++ + + +KI +
Sbjct: 134 LWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVGELNTRLTDDVSKINDGIGDKIGMFF 193
Query: 3132 AFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIA 2953
+T F G + F + W+L + S I S + + + T K+ YA AG++A
Sbjct: 194 QSITTFLAGFIIGFISGWKLTLVILAVSPLIGLSSALWAKVLTSFTNKELQAYAKAGAVA 253
Query: 2952 FQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVL 2773
+ L A +TV + GQ+ E+ERY + L+ + GI++A+ SIS G+ Y + +
Sbjct: 254 EEVLAAIRTVIAFGGQQKELERYNKNLEEAKNVGIKKAITASISIGIAYLLVYASYALAF 313
Query: 2772 YVGATMIYSG-------------------------------------TLETAVVVRDDNV 2704
+ G +++ S E ++ ++
Sbjct: 314 WYGTSLVLSNEYSIGEVLTVFFSILLGTFSIGHLAPNIEAFANARGAAFEIFKIIDNEPS 373
Query: 2703 IEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKS 2524
I+ T + GN+ FKNV F+YP+R + Q+LKG++ V++G+ +ALVG SG GKS
Sbjct: 374 IDSFSTKGYKPDSIMGNLEFKNVHFNYPSRSEVQILKGLNLKVKSGQTVALVGNSGCGKS 433
Query: 2523 TVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPN 2344
T VQL+ Y+ G + IDG D+ +N++ LR +IGVVSQEPVLF TTI ENIR+G +
Sbjct: 434 TTVQLMQRLYDPLEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRED 493
Query: 2343 VSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLL 2164
V++ EI A+++ANAYDF+ P T+VGERG QLSGGQKQRIAIAR LVRNPKILLL
Sbjct: 494 VTMDEIEKAVKEANAYDFIMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLL 553
Query: 2163 DEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDE 1984
DEATSALD ESE VVQ AL+ A +GRTTIV+AHRLST+RNA I G IVE GNHDE
Sbjct: 554 DEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDE 613
Query: 1983 LIAKRGVYNDLVQAQ-----LLESHDDHEELPPLAARQLSQE--LSPLHSYAIQRSTSND 1825
L+ ++G+Y LV Q + ++ + A +L+ E SPL +I RS
Sbjct: 614 LMREKGIYFKLVMTQTRGNEIEPGNNAYGSQSDTDASELTSEESKSPLIRRSIYRSVHRK 673
Query: 1824 AGVHDDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLI 1645
D + + E E + I+ ++ +L + V + I G P+ A +
Sbjct: 674 ---QDQERRLSMKEAVDEDVPLVSFWRILNLNLSEWPYLLVGVLCAVINGCIQPVFAIVF 730
Query: 1644 VRTYEGFAMIG--EDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKS 1471
R F+ E +L++L F+ + + +T + Q + FGK E L+ R+R
Sbjct: 731 SRIVGVFSRDDDHETKRQNCNLFSLFFLVMGLISFVTYFFQGFTFGKAGEILTKRVRYMV 790
Query: 1470 FSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASL 1291
F ML +++DD +S L+ RL +D+S+VK A+ RL V V + + + +
Sbjct: 791 FKSMLRQDISWFDDHKNSTGSLTTRLASDASSVKGAMGARLAVVTQNVANLGTGVILSLV 850
Query: 1290 YCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNL 1111
Y W++TL +++ P +D E S + A EA+EN RT+ +L
Sbjct: 851 YGWQLTLLLVVIIPLIVLGGIIEMKLLSGQALKDKKQLEISGKIATEAIENFRTIVSLTR 910
Query: 1110 EDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPM 931
E K ++ ++ LQ +++ K+A + G + + F Y+ F+FG YL ++ +
Sbjct: 911 EQKFETMYAQSLQVPYRNAMKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVAQQLMTFE 970
Query: 930 DTYLVLMTLSMTANMAGSAAAYLPDYKKA-VHAAGLIFHLFTYPATMPFSSSDGKKNIEK 754
+ LV + A AG+ +++ PDY KA V A+ +I + P +S+ K + +
Sbjct: 971 NVMLVFSAVVFGAMAAGNTSSFAPDYAKAKVSASHIIRIIEKTPEIDSYSTEGLKPTLLE 1030
Query: 753 GEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDG 574
G + VQF+Y RP+ +L G++L+V G+TLALVG SGCGKST++ LLERFY + G
Sbjct: 1031 GNVKFNGVQFNYPTRPNIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAG 1090
Query: 573 EVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYG-LTRSVPQLELEKALQTA 397
V +D + ++ +N+ LR++L +VSQEP LF+CSI EN+ YG +R+V E+ +A + A
Sbjct: 1091 SVFLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRAVSHEEIVRAAKEA 1150
Query: 396 NAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEK 217
N F+ P +T VG++G QLSGGQKQRIAIARA++R P +LLLDEATSALD++SEK
Sbjct: 1151 NIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEK 1210
Query: 216 VVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQ 37
VVQ ALD A E + +V+AHRLST+ NAD I V++NGKV E GTH++LL ++ IY+ +VQ
Sbjct: 1211 VVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIENGKVKEHGTHQQLLAQKGIYFSMVQ 1270
Score = 323 bits (827), Expect = 2e-86
Identities = 188/494 (38%), Positives = 282/494 (57%), Gaps = 3/494 (0%)
Frame = -1
Query: 1488 RLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIA 1309
++R K F +++ ++D H L+ RL D S + + D++G ++
Sbjct: 145 KIRQKFFHAIMNQEIGWFDV--HDVGELNTRLTDDVSKINDGIGDKIGMFFQSITTFLAG 202
Query: 1308 ITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRT 1129
+ WK+TL +L P ++ A+ + A E L +RT
Sbjct: 203 FIIGFISGWKLTLVILAVSPLIGLSSALWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRT 262
Query: 1128 VRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALR 949
V A + K + +++L++ K+AI + G++ Y+++F +GT L L
Sbjct: 263 VIAFGGQQKELERYNKNLEEAKNVGIKKAITASISIGIAYLLVYASYALAFWYGTSLVLS 322
Query: 948 KEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLF-TYPATMPFSSSDG 772
E + + V ++ + G A + + A AA IF + P+ FS+
Sbjct: 323 NEYSIGEVLTVFFSILLGTFSIGHLAPNIEAFANARGAAFEIFKIIDNEPSIDSFSTKGY 382
Query: 771 KKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERF 592
K + G + +NV F+Y R + IL G+NLKV G+T+ALVG SGCGKST + L++R
Sbjct: 383 KPDSIMGNLEFKNVHFNYPSRSEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRL 442
Query: 591 YHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEK 412
Y ++G V ID +++ IN+ +LR + +VSQEP LF +I EN+ YG V E+EK
Sbjct: 443 YDPLEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYG-REDVTMDEIEK 501
Query: 411 ALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALD 232
A++ ANA++F+ + P DTLVGERGAQLSGGQKQRIAIARA++RNPK+LLLDEATSALD
Sbjct: 502 AVKEANAYDFIMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALD 561
Query: 231 SDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIY 52
++SE VVQ ALD A E +T+V+AHRLSTV NAD IA G + EQG H+EL+R++ IY
Sbjct: 562 TESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIY 621
Query: 51 WRLV--QKQGIQVE 16
++LV Q +G ++E
Sbjct: 622 FKLVMTQTRGNEIE 635
Score = 304 bits (779), Expect = 9e-81
Identities = 194/577 (33%), Positives = 307/577 (52%), Gaps = 41/577 (7%)
Frame = -1
Query: 3549 LLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQVV 3370
L+GVL +++ G QP + F + V + +E + N
Sbjct: 710 LVGVLCAVINGCIQPVFAIVFSRIVGVF---------------SRDDDHETKRQNCNLFS 754
Query: 3369 FHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSV--STGHLST 3196
F + G F+ Q G+ T RVR +L++D +FD STG L+T
Sbjct: 755 LFFLVMGLISFVTYFFQGFTFGKAGEILTKRVRYMVFKSMLRQDISWFDDHKNSTGSLTT 814
Query: 3195 VLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINS 3016
L + + ++A++ V + G L+ W+L + I G I
Sbjct: 815 RLASDASSVKGAMGARLAVVTQNVANLGTGVILSLVYGWQLTLLLVVIIPLIVLGGIIEM 874
Query: 3015 AGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRA- 2839
+ K +G IA + + ++T+ SL ++ Y + L+ + +++A
Sbjct: 875 KLLSGQALKDKKQLEISGKIATEAIENFRTIVSLTREQKFETMYAQSLQVPYRNAMKKAH 934
Query: 2838 ---LMYSISRGVTYFFCNSL---------NTVVLYVGATMIYSGTLETAVVVRDDN---- 2707
+ +S ++ + YF + ++ + +++S + A+ + +
Sbjct: 935 VFGITFSFTQAMMYFSYAACFRFGAYLVAQQLMTFENVMLVFSAVVFGAMAAGNTSSFAP 994
Query: 2706 --------------VIEKD-ETD-YDVE----VEVNGNISFKNVKFSYPTRPDAQVLKGI 2587
+IEK E D Y E + GN+ F V+F+YPTRP+ VL+G+
Sbjct: 995 DYAKAKVSASHIIRIIEKTPEIDSYSTEGLKPTLLEGNVKFNGVQFNYPTRPNIPVLQGL 1054
Query: 2586 SFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVV 2407
S +V+ G+ +ALVG+SG GKSTVVQLL +Y+ +G++F+DG ++ +N++ LR +G+V
Sbjct: 1055 SLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAHLGIV 1114
Query: 2406 SQEPVLFNTTIEENIRFGNPN--VSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQL 2233
SQEP+LF+ +I ENI +G+ + VS EI A ++AN + F+ S P T VG++GTQL
Sbjct: 1115 SQEPILFDCSIAENIAYGDNSRAVSHEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQL 1174
Query: 2232 SGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLST 2053
SGGQKQRIAIAR LVR P ILLLDEATSALD ESE+VVQ+AL+ A +GRT IV+AHRLST
Sbjct: 1175 SGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLST 1234
Query: 2052 IRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQA 1942
I+NA I+V++ G++ E G H +L+A++G+Y +VQA
Sbjct: 1235 IQNADLIVVIENGKVKEHGTHQQLLAQKGIYFSMVQA 1271
>gi|48267183|gb|AAQ63650.3| multi-drug resistance P-glycoprotein 1;
PGY1; MDR1; GP170; ABC20; P-GP [Oryctolagus cuniculus]
Length = 1279
Score = 744 bits (1920), Expect = 0.0
Identities = 457/1258 (36%), Positives = 690/1258 (54%), Gaps = 59/1258 (4%)
Frame = -1
Query: 3627 EKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNA 3448
EK+P+ + +F +F+ S+ +K ++G L +++ G P M FG+++ N
Sbjct: 27 EKRPT-VSAF--AMFRYSNWLDKLYMVVGTLAAIIHGAALPLMMLVFGDMTDSFSNPGNM 83
Query: 3447 I----NNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTY 3280
I N + + YE E M +++ G + A +Q + T+
Sbjct: 84 IPANITNLNMSNISASEIYEHLEEEMTTYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQTF 143
Query: 3279 RVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTA 3100
++RKQ+ +++++ +FD G L+T L D++ + + +KI + ++ F G
Sbjct: 144 KIRKQFFHSIMRQEIGWFDVHDVGELNTRLTDDVSKINDGIGDKIGMFFQSMSTFFTGFI 203
Query: 3099 LAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVC 2920
+ F W+L + S + S + + + T K+ YA AG++A + L A +TV
Sbjct: 204 VGFTRGWKLTLVILAISPVLGLSAALWAKIMSSFTDKELLAYAKAGAVAEEVLAAIRTVI 263
Query: 2919 SLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTY-----------FFCNSLNTVVL 2773
+ GQ+ E+ERY + L+ ++ GI++A+ +IS GV + ++ N L +
Sbjct: 264 AFGGQQKELERYNKNLEEAKRIGIKKAITANISVGVAFLLMYASYALAFWYWNHLGHLKE 323
Query: 2772 Y-------------VGATMI--YSGTLETAVVVRD---------DNVIEKD---ETDYDV 2674
Y VGA I S +E R DN+ D E +
Sbjct: 324 YSIGQVLTVFFSVLVGAFSIGQASPNVEAFANARGAAYEIFRIIDNMPSIDSYSEAGHKP 383
Query: 2673 EVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYY 2494
+ + GN+ F+NV FSYP+R + ++LKG++ V++G+ +ALVG SG GKST VQL+ Y
Sbjct: 384 D-NIKGNLEFRNVHFSYPSRKEVKILKGLNLKVESGQTVALVGNSGCGKSTTVQLMRRLY 442
Query: 2493 NIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGAL 2314
+ G + IDG D+ MN++ LR + GVVSQEPVLF TTI EN+R+G +V++ EI A+
Sbjct: 443 DPTDGVVSIDGQDIRTMNVRYLREITGVVSQEPVLFATTIAENVRYGREDVTMDEIEKAV 502
Query: 2313 RKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNE 2134
++ANAY+F+ P T+VGERG QLSGGQKQRIAIAR LVRNPKILLLDEATSALD E
Sbjct: 503 KEANAYNFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTE 562
Query: 2133 SEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYND 1954
SE VVQ AL+ A +GRTTIV+AHRLST+RNA I G IVE GNH+EL+ ++GVY
Sbjct: 563 SEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDNGVIVERGNHEELMRQKGVYFR 622
Query: 1953 LVQAQLL-----------ESHDDHEELPPLAARQLSQELSPLHSYAIQRSTSNDA--GVH 1813
LV Q ES + +L ++A++ L I+R +S+ + G
Sbjct: 623 LVTMQTAGNEIDLENSASESRGEKMDLVEMSAKESGSSL-------IRRRSSHKSFHGAQ 675
Query: 1812 DDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTY 1633
D + E E + I+K ++ + + V + I G P A + +
Sbjct: 676 GQDGKLSTTEAQNENVPPVSFWRIMKLNLTEWPYFLVGVICAIINGGLQPAFAVVFSKIV 735
Query: 1632 EGFAMIGED--MLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHM 1459
F +D S L++L F+ L + +T + Q + FGK E L+ RLR F M
Sbjct: 736 GVFTRNDDDETKRRNSDLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSM 795
Query: 1458 LSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWK 1279
L +++DDP ++ L+ RL D++ VK A RL + + + I + +Y W+
Sbjct: 796 LRQDVSWFDDPKNTTGALTTRLANDAAQVKGATGSRLAVIAQNIANLGTGIIISLVYGWQ 855
Query: 1278 MTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKI 1099
+TL +L P +D E S + A EA+EN RTV +L E K
Sbjct: 856 LTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKF 915
Query: 1098 MSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYL 919
++ ++ LQ +++ ++A I G + + F Y+ F+FG +L R+ ++ + L
Sbjct: 916 ENMYAQSLQVPYRNSLEKAHIFGITFSFTQAMMYFSYAGCFRFGAFLVARELMSFENVLL 975
Query: 918 VLMTLSMTANMAGSAAAYLPDYKKA-VHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEII 742
V + A G +++ PDY KA + A+ +I L P +S+ K +G +
Sbjct: 976 VFSAVVFGAMAVGQVSSFAPDYAKAKISASHIIMILEKLPKIDSYSTEGLKPGTLEGNMT 1035
Query: 741 GENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKI 562
++V F+Y RPD +L G+NL+V G+TLALVGPSGCGKST++ L+ERFY + G V +
Sbjct: 1036 FKDVVFNYPTRPDIPVLQGLNLQVKKGQTLALVGPSGCGKSTVVQLIERFYDPLAGTVLL 1095
Query: 561 DSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYG-LTRSVPQLELEKALQTANAFN 385
D + V +N+ LR++L +VSQEP LF+CSI EN+ YG +R V Q E+ KA + AN
Sbjct: 1096 DGKEVNQLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIIKAAKEANIHA 1155
Query: 384 FVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQN 205
F+ P +T VG++G QLSGGQKQRIAIARA++R P +LLLDEATSA D++SEKVVQ
Sbjct: 1156 FIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSAPDTESEKVVQE 1215
Query: 204 ALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
ALD A E + VV+AHRLST+ NAD I V +NG+V E GTH +LL ++ IY+ +V Q
Sbjct: 1216 ALDKAREGRTCVVIAHRLSTIQNADMIVVFQNGRVKECGTHHQLLAQKGIYFSMVSVQ 1273
>gi|191157|gb|AAA37005.1| p-glycoprotein
Length = 1169
Score = 744 bits (1920), Expect = 0.0
Identities = 438/1168 (37%), Positives = 647/1168 (54%), Gaps = 50/1168 (4%)
Frame = -1
Query: 3384 MNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGH 3205
M +++ G I A +Q + +++R+++ ++ ++ +FD G
Sbjct: 1 MTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVGE 60
Query: 3204 LSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGF 3025
L+T L D++ + E +KI + + F G + F W+L + S + S
Sbjct: 61 LNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTLVILAISPVLGLSAG 120
Query: 3024 INSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIR 2845
I + + T K+ YA AG++A + L A +TV + GQK E+ERY L+ ++ GI+
Sbjct: 121 IWAKILSSFTDKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEAKRLGIK 180
Query: 2844 RALMYSISRGVTYFFCNSLNTVVLYVGATMIYSG--------TLETAVVVRDD------- 2710
+A+ +IS G + + + + G +++ S T+ AV++
Sbjct: 181 KAITANISMGAAFLLIYASYALAFWYGTSLVISKEYSIGQVLTVFFAVLIAPFSIGQASP 240
Query: 2709 ----------------NVIEK-------DETDYDVEVEVNGNISFKNVKFSYPTRPDAQV 2599
N+I+ + Y + + GN+ FKN+ FSYP+R D Q+
Sbjct: 241 NIEAFANARGAAYEIFNIIDNKPSIDSFSKNGYKPD-NIKGNLEFKNIHFSYPSRKDVQI 299
Query: 2598 LKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRV 2419
LKG++ VQ+G+ +ALVG SG GKST VQLL Y+ G + IDG D+ +N++ LR +
Sbjct: 300 LKGLNLKVQSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGVVSIDGQDIRTINVRYLREI 359
Query: 2418 IGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGT 2239
IGVVSQEPVLF TTI ENIR+G NV++ EI A+++ANAYDF+ P T+VGERG
Sbjct: 360 IGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGA 419
Query: 2238 QLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRL 2059
QLSGGQKQRIAIAR LVRNPKILLLDEATSALD ESE VVQ AL+ A +GRTTIV+AHRL
Sbjct: 420 QLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRL 479
Query: 2058 STIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLL--------ESHDDHEELP 1903
ST+RNA I G IVE GNH+EL+ ++G+Y LV Q E + E+
Sbjct: 480 STVRNADIIAGFDGGVIVEQGNHEELMREKGIYFKLVMTQTAGNEIELGNEVGESKNEID 539
Query: 1902 PLAARQLSQELSPLHSYAIQRSTSNDAGVHDDDMERILDELSKEGAKKSNLREIVKQCRP 1723
L S + + +RS G HD D + E E + I+K
Sbjct: 540 NLDMSSKDSASSLIRRRSTRRSI---RGPHDQDRKLSTKEALDEDVPPISFWRILKLNSS 596
Query: 1722 DYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGED--MLYYSHLWALSFMFLAVFR 1549
++ + + +F + + G P + + + F +D + S+L++L F+ L V
Sbjct: 597 EWPYFVVGIFCAIVNGALQPAFSIIFSKVVGVFTRNTDDETKRHDSNLFSLLFLILGVIS 656
Query: 1548 PLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVK 1369
+T + Q + FGK E L+ RLR F ML +++D+P ++ L+ RL D+ VK
Sbjct: 657 FITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDNPKNTTGALTTRLANDAGQVK 716
Query: 1368 AAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQED 1189
A RL + + + I + +Y W++TL +L P +D
Sbjct: 717 GATGARLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKD 776
Query: 1188 TIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSL 1009
E S + A EA+EN RTV +L E K ++ ++ LQ +++ K+A + G +
Sbjct: 777 KKELEGSGKIATEAIENFRTVVSLTREQKFENMYAQSLQIPYRNALKKAHVFGITFSFTQ 836
Query: 1008 SCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKA-VHAA 832
+ F Y+ F+FG YL R+ + + LV + A G +++ PDY KA V A+
Sbjct: 837 AMMYFSYAACFRFGAYLVARELMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKAKVSAS 896
Query: 831 GLIFHLFTYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTL 652
+I + P+ +S+ K N +G + V F+Y RPD +L G+NL+V G+TL
Sbjct: 897 HIIMIIEKVPSIDSYSTGGLKPNTLEGNVKFNEVVFNYPTRPDIPVLQGLNLEVKKGQTL 956
Query: 651 ALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCS 472
ALVG SGCGKST++ LLERFY + G V +D + V +N+ LR++L +VSQEP LF+CS
Sbjct: 957 ALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEVNQLNVQWLRAHLGIVSQEPILFDCS 1016
Query: 471 IRENLLYG-LTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAI 295
I EN+ YG +R V Q E+E+A + AN F+ P +T VG++G QLSGGQKQRIAI
Sbjct: 1017 IAENIAYGDNSRVVSQDEIERAAKEANIHQFIESLPDKYNTRVGDKGTQLSGGQKQRIAI 1076
Query: 294 ARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVL 115
ARA++R P +LLLDEATSALD++SEKVVQ ALD A E + +V+AHRLST+ NAD I V+
Sbjct: 1077 ARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVI 1136
Query: 114 KNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
+NGKV E GTH++LL ++ IY+ +V Q
Sbjct: 1137 QNGKVKEHGTHQQLLAQKGIYFSMVSVQ 1164
>gi|46394982|gb|AAS91647.1| multidrug resistance protein 1;
P-glycoprotein [Canis familiaris]
Length = 1281
Score = 744 bits (1920), Expect = 0.0
Identities = 449/1263 (35%), Positives = 680/1263 (53%), Gaps = 61/1263 (4%)
Frame = -1
Query: 3636 QSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVL--- 3466
+ EKKP+ + +F +F+ S+ ++ L+G + +++ G P M FG ++
Sbjct: 26 EKKEKKPT-VSTF--AMFRYSNWLDRLYMLVGTMAAIIHGAALPLMMLVFGNMTDSFANA 82
Query: 3465 ---------VTITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHA 3313
V I +I N T + E M +++ G + A +Q +
Sbjct: 83 GISRNKTFPVIINESITNNT------QHFINHLEEEMTTYAYYYSGIGAGVLVAAYIQVS 136
Query: 3312 IMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALII 3133
++RKQ+ +++++ +FD G L+T L D++ + E +KI +
Sbjct: 137 FWCLAAGRQILKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFF 196
Query: 3132 AFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIA 2953
+ F G + F W+L + S + S I + + T K+ YA AG++A
Sbjct: 197 QSIATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAIWAKILSSFTDKELLAYAKAGAVA 256
Query: 2952 FQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVL 2773
+ L A +TV + GQK E+ERY + L+ ++ GI++A+ +IS G + + +
Sbjct: 257 EEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAF 316
Query: 2772 YVGATMIYSG-------------------------------------TLETAVVVRDDNV 2704
+ G +++ S E ++ +
Sbjct: 317 WYGTSLVLSSEYSIGQVLTVFFSVLIGAFSIGQASPSIEAFANARGAAYEIFKIIDNKPS 376
Query: 2703 IEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKS 2524
I+ + GN+ FKNV FSYP+R + ++LKG++ VQ+G+ +ALVG SG GKS
Sbjct: 377 IDSYSKSGHKPDNIKGNLEFKNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKS 436
Query: 2523 TVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPN 2344
T VQL+ Y+ G + IDG D+ +N++ LR + GVVSQEPVLF TTI ENIR+G N
Sbjct: 437 TTVQLMQRLYDPTDGMVCIDGQDIRTINVRHLREITGVVSQEPVLFATTIAENIRYGREN 496
Query: 2343 VSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLL 2164
V++ EI A+++ANAYDF+ P T+VGERG QLSGGQKQRIAIAR LVRNPKILLL
Sbjct: 497 VTMDEIEKAVKEANAYDFIMKLPNKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLL 556
Query: 2163 DEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDE 1984
DEATSALD ESE VVQ AL+ A +GRTTIV+AHRLST+RNA I G IVE GNHDE
Sbjct: 557 DEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDE 616
Query: 1983 LIAKRGVYNDLVQAQLLESHDDHEELPPLAARQLSQ----ELSPLHS-YAIQRSTSNDAG 1819
L+ ++G+Y LV +++ + EL S+ E+SP S ++ + S
Sbjct: 617 LMKEKGIYFKLV---TMQTRGNEIELENATGESKSESDALEMSPKDSGSSLIKRRSTRRS 673
Query: 1818 VH---DDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQL 1648
+H D + E E + I+K ++ + + +F + I G P + +
Sbjct: 674 IHAPQGQDRKLGTKEDLNENVPPVSFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSII 733
Query: 1647 IVRTYEGFAM--IGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIK 1474
R F E S+++++ F+ L + +T + Q + FGK E L+ RLR
Sbjct: 734 FSRIIGIFTRDEDPETKRQNSNMFSVLFLVLGIISFITFFLQGFTFGKAGEILTKRLRYM 793
Query: 1473 SFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTAS 1294
F ML +++DDP ++ L+ RL D++ VK A+ RL + + + I +
Sbjct: 794 VFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISL 853
Query: 1293 LYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALN 1114
+Y W++TL +L P +D E + + A EA+EN RTV +L
Sbjct: 854 IYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLT 913
Query: 1113 LEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAP 934
E K + ++ LQ +++ ++A I G + ++ + F Y+ F+FG YL + +
Sbjct: 914 REQKFEYMYAQSLQVPYRNSLRKAHIFGVSFSITQAMMYFSYAGCFRFGAYLVANEFMNF 973
Query: 933 MDTYLVLMTLSMTANMAGSAAAYLPDYKKA-VHAAGLIFHLFTYPATMPFSSSDGKKNIE 757
D LV + A G +++ PDY KA V AA +I + P +S K N
Sbjct: 974 QDVLLVFSAIVFGAMAVGQVSSFAPDYAKAKVSAAHVIMIIEKSPLIDSYSPHGLKPNTL 1033
Query: 756 KGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVD 577
+G + V F+Y RPD +L G++L+V G+TLALVG SGCGKST++ LLERFY +
Sbjct: 1034 EGNVTFNEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLA 1093
Query: 576 GEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYG-LTRSVPQLELEKALQT 400
G V ID + ++ +N+ LR++L +VSQEP LF+CSI EN+ YG +R V E+ +A +
Sbjct: 1094 GSVLIDGKEIKHLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSHEEIVQAAKE 1153
Query: 399 ANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSE 220
AN +F+ P+ +T VG++G QLSGGQKQRIAIARA++R P +LLLDEATSALD++SE
Sbjct: 1154 ANIHHFIETLPEKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESE 1213
Query: 219 KVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLV 40
KVVQ ALD A E + +V+AHRLST+ NAD I V +NGKV E GTH++LL ++ IY+ +V
Sbjct: 1214 KVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGKVKEHGTHQQLLAQKGIYFSMV 1273
Query: 39 QKQ 31
Q
Sbjct: 1274 SVQ 1276
Score = 323 bits (828), Expect = 2e-86
Identities = 190/510 (37%), Positives = 288/510 (56%), Gaps = 3/510 (0%)
Frame = -1
Query: 1536 YCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVD 1357
Y Q ++ + + ++R + F ++ ++D H L+ RL D S + +
Sbjct: 132 YIQVSFWCLAAGRQILKIRKQFFHAIMRQEIGWFDV--HDVGELNTRLTDDVSKINEGIG 189
Query: 1356 DRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAF 1177
D++G ++ WK+TL +L P ++ +A+
Sbjct: 190 DKIGMFFQSIATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAIWAKILSSFTDKELLAY 249
Query: 1176 ENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFL 997
+ A E L +RTV A + K + +++L++ + K+AI + G +
Sbjct: 250 AKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIY 309
Query: 996 FVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFH 817
Y+++F +GT L L E + V ++ + A G A+ + + A AA IF
Sbjct: 310 ASYALAFWYGTSLVLSSEYSIGQVLTVFFSVLIGAFSIGQASPSIEAFANARGAAYEIFK 369
Query: 816 LF-TYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVG 640
+ P+ +S S K + KG + +NV F Y R + IL G+NLKV G+T+ALVG
Sbjct: 370 IIDNKPSIDSYSKSGHKPDNIKGNLEFKNVHFSYPSRKEVKILKGLNLKVQSGQTVALVG 429
Query: 639 PSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIREN 460
SGCGKST + L++R Y DG V ID +++ IN+ HLR +VSQEP LF +I EN
Sbjct: 430 NSGCGKSTTVQLMQRLYDPTDGMVCIDGQDIRTINVRHLREITGVVSQEPVLFATTIAEN 489
Query: 459 LLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAIL 280
+ YG +V E+EKA++ ANA++F+ + P DTLVGERGAQLSGGQKQRIAIARA++
Sbjct: 490 IRYG-RENVTMDEIEKAVKEANAYDFIMKLPNKFDTLVGERGAQLSGGQKQRIAIARALV 548
Query: 279 RNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKV 100
RNPK+LLLDEATSALD++SE VVQ ALD A + +T+V+AHRLSTV NAD IA +G +
Sbjct: 549 RNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVI 608
Query: 99 AEQGTHEELLRKRSIYWRLV--QKQGIQVE 16
E+G H+EL++++ IY++LV Q +G ++E
Sbjct: 609 VEKGNHDELMKEKGIYFKLVTMQTRGNEIE 638
>gi|8926217|gb|AAF81747.1| his-tagged-multidrug resistance
glycoprotein MDR1 [synthetic construct]
Length = 1287
Score = 743 bits (1919), Expect = 0.0
Identities = 448/1263 (35%), Positives = 680/1263 (53%), Gaps = 61/1263 (4%)
Frame = -1
Query: 3636 QSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVL--- 3466
+ EKKP+ + +F +F+ S+ ++ L+G + +++ G P M FG ++
Sbjct: 32 EKKEKKPT-VSTF--AMFRYSNWLDRLYMLVGTMAAIIHGAALPLMMLVFGNMTDSFANA 88
Query: 3465 ---------VTITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHA 3313
V I +I N T + E M +++ G + A +Q +
Sbjct: 89 GISRNKTFPVIINESITNNT------QHFINHLEEEMTTYAYYYSGIGAGVLVAAYIQVS 142
Query: 3312 IMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALII 3133
++RKQ+ +++++ +FD G L+T L D++ + E +KI +
Sbjct: 143 FWCLAAGRQILKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFF 202
Query: 3132 AFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIA 2953
+ F G + F W+L + S + S I + + T K+ YA AG++A
Sbjct: 203 QSIATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAIWAKILSSFTDKELLAYAKAGAVA 262
Query: 2952 FQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVL 2773
+ L A +TV + GQK E+ERY + L+ ++ GI++A+ +IS G + + +
Sbjct: 263 EEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAF 322
Query: 2772 YVGATMIYSG-------------------------------------TLETAVVVRDDNV 2704
+ G +++ S E ++ +
Sbjct: 323 WYGTSLVLSSEYSIGQVLTVFFSVLIGAFSIGQASPSIEAFANARGAAYEIFKIIDNKPS 382
Query: 2703 IEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKS 2524
I+ + GN+ FKNV FSYP+R + ++LKG++ VQ+G+ +ALVG SG GKS
Sbjct: 383 IDSYSKSGHKPDNIKGNLEFKNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKS 442
Query: 2523 TVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPN 2344
T VQL+ Y+ G + IDG D+ +N++ LR + GVVSQEPVLF TTI ENIR+G N
Sbjct: 443 TTVQLMQRLYDPTDGMVCIDGQDIRTINVRHLREITGVVSQEPVLFATTIAENIRYGREN 502
Query: 2343 VSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLL 2164
V++ EI A+++ANAYDF+ P T+VGERG QLSGGQKQRIAIAR LVRNPKILLL
Sbjct: 503 VTMDEIEKAVKEANAYDFIMKLPNKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLL 562
Query: 2163 DEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDE 1984
DEATSALD ESE VVQ AL+ A +GRTTIV+AHRLST+RNA I G IVE GNHDE
Sbjct: 563 DEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDE 622
Query: 1983 LIAKRGVYNDLVQAQLLESHDDHEELPPLAARQLSQ----ELSPLHS-YAIQRSTSNDAG 1819
L+ ++G+Y LV +++ + EL S+ E+SP S ++ + S
Sbjct: 623 LMKEKGIYFKLV---TMQTRGNEIELENATGESKSESDALEMSPKDSGSSLIKRRSTRRS 679
Query: 1818 VH---DDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQL 1648
+H D + E E + I+K ++ + + +F + I G P + +
Sbjct: 680 IHAPQGQDRKLGTKEDLNENVPPVSFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSII 739
Query: 1647 IVRTYEGFAM--IGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIK 1474
R F E S+++++ F+ L + +T + Q + FGK E L+ RLR
Sbjct: 740 FSRIIGIFTRDEDPETKRQNSNMFSVLFLVLGIISFITFFLQGFTFGKAGEILTKRLRYM 799
Query: 1473 SFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTAS 1294
F ML +++DDP ++ L+ RL D++ VK A+ RL + + + I +
Sbjct: 800 VFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISL 859
Query: 1293 LYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALN 1114
+Y W++TL +L P +D E + + A EA+EN RTV +L
Sbjct: 860 IYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLT 919
Query: 1113 LEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAP 934
E K + ++ LQ +++ ++A I G + ++ + F Y+ F+FG YL + +
Sbjct: 920 REQKFEYMYAQSLQVPYRNSLRKAHIFGVSFSITQAMMYFSYAGCFRFGAYLVANEFMNF 979
Query: 933 MDTYLVLMTLSMTANMAGSAAAYLPDYKKA-VHAAGLIFHLFTYPATMPFSSSDGKKNIE 757
D LV + A G +++ PDY KA V AA +I + P +S K N
Sbjct: 980 QDVLLVFSAIVFGAMAVGQVSSFAPDYAKAKVSAAHVIMIIEKSPLIDSYSPHGLKPNTL 1039
Query: 756 KGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVD 577
+G + V F+Y RPD +L G++L+V G+TLALVG SGCGKST++ LLERFY +
Sbjct: 1040 EGNVTFNEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLA 1099
Query: 576 GEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYG-LTRSVPQLELEKALQT 400
G V ID + ++ +N+ LR++L +VSQEP LF+CSI EN+ YG +R V E+ +A +
Sbjct: 1100 GSVLIDGKEIKHLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSHEEIMQAAKE 1159
Query: 399 ANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSE 220
AN +F+ P+ +T VG++G QLSGGQKQRIAIARA++R P +LLLDEATSALD++SE
Sbjct: 1160 ANIHHFIETLPEKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESE 1219
Query: 219 KVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLV 40
KVVQ ALD A E + +V+AHRLST+ NAD I V +NGKV E GTH++LL ++ IY+ ++
Sbjct: 1220 KVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGKVKEHGTHQQLLAQKGIYFSMI 1279
Query: 39 QKQ 31
Q
Sbjct: 1280 SVQ 1282
Score = 323 bits (828), Expect = 2e-86
Identities = 190/510 (37%), Positives = 288/510 (56%), Gaps = 3/510 (0%)
Frame = -1
Query: 1536 YCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVD 1357
Y Q ++ + + ++R + F ++ ++D H L+ RL D S + +
Sbjct: 138 YIQVSFWCLAAGRQILKIRKQFFHAIMRQEIGWFDV--HDVGELNTRLTDDVSKINEGIG 195
Query: 1356 DRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAF 1177
D++G ++ WK+TL +L P ++ +A+
Sbjct: 196 DKIGMFFQSIATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAIWAKILSSFTDKELLAY 255
Query: 1176 ENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFL 997
+ A E L +RTV A + K + +++L++ + K+AI + G +
Sbjct: 256 AKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIY 315
Query: 996 FVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFH 817
Y+++F +GT L L E + V ++ + A G A+ + + A AA IF
Sbjct: 316 ASYALAFWYGTSLVLSSEYSIGQVLTVFFSVLIGAFSIGQASPSIEAFANARGAAYEIFK 375
Query: 816 LF-TYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVG 640
+ P+ +S S K + KG + +NV F Y R + IL G+NLKV G+T+ALVG
Sbjct: 376 IIDNKPSIDSYSKSGHKPDNIKGNLEFKNVHFSYPSRKEVKILKGLNLKVQSGQTVALVG 435
Query: 639 PSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIREN 460
SGCGKST + L++R Y DG V ID +++ IN+ HLR +VSQEP LF +I EN
Sbjct: 436 NSGCGKSTTVQLMQRLYDPTDGMVCIDGQDIRTINVRHLREITGVVSQEPVLFATTIAEN 495
Query: 459 LLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAIL 280
+ YG +V E+EKA++ ANA++F+ + P DTLVGERGAQLSGGQKQRIAIARA++
Sbjct: 496 IRYG-RENVTMDEIEKAVKEANAYDFIMKLPNKFDTLVGERGAQLSGGQKQRIAIARALV 554
Query: 279 RNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKV 100
RNPK+LLLDEATSALD++SE VVQ ALD A + +T+V+AHRLSTV NAD IA +G +
Sbjct: 555 RNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVI 614
Query: 99 AEQGTHEELLRKRSIYWRLV--QKQGIQVE 16
E+G H+EL++++ IY++LV Q +G ++E
Sbjct: 615 VEKGNHDELMKEKGIYFKLVTMQTRGNEIE 644
>gi|31442763|gb|AAN07780.2| multidrug resistance p-glycoprotein
[Macaca fascicularis]
Length = 1283
Score = 743 bits (1919), Expect = 0.0
Identities = 450/1271 (35%), Positives = 674/1271 (52%), Gaps = 57/1271 (4%)
Frame = -1
Query: 3672 ENSNNFSTPLLPQSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSY 3493
E N F + D+K+ S + F+ S+ +K ++G L +++ G P M
Sbjct: 12 EKKNFFKLNNKSKKDKKERKPTVSVFSM-FRYSNWLDKLYMVVGTLAAIIHGAGLPLMML 70
Query: 3492 TFGEVSQVLVTITNA-------INNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFI 3334
FG+++ N NN E M + +++ G +
Sbjct: 71 VFGDMTDTFANAGNLGDLGALLFNNTNSSNITDTVPVMNLEEDMTRYAYYYSGIGAGVLV 130
Query: 3333 FASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFN 3154
A +Q + +++RKQ+ +++++ +FD G L+T L D++ + E
Sbjct: 131 AAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIG 190
Query: 3153 EKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHY 2974
+KI + + F G + F W+L + S + S + + + T K+ Y
Sbjct: 191 DKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAY 250
Query: 2973 ANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCN 2794
A AG++A + L A +TV + GQK E+ERY + L+ ++ GI++A+ +IS G +
Sbjct: 251 AKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIY 310
Query: 2793 SLNTVVLYVGATMIYS-------------------------------------GTLETAV 2725
+ + + G T++ S E
Sbjct: 311 ASYALAFWYGTTLVLSKEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAFEIFK 370
Query: 2724 VVRDDNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVG 2545
++ + I+ + GN+ F+NV FSYP+R + ++LKG++ VQ+G+ +ALVG
Sbjct: 371 IIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVG 430
Query: 2544 ASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEEN 2365
SG GKST VQL+ Y+ G + +DG D+ +N++ LR +IGVVSQEPVLF TTI EN
Sbjct: 431 NSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAEN 490
Query: 2364 IRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVR 2185
IR+G +V++ EI A+++ANAYDF+ P+ T+VGERG QLSGGQKQRIAIAR LVR
Sbjct: 491 IRYGREDVTMDEIEKAVKEANAYDFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVR 550
Query: 2184 NPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIV 2005
NPKILLLDEATSALD ESE VVQ AL+ A +GRTTIV+AHRLST+RNA I G IV
Sbjct: 551 NPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIV 610
Query: 2004 EVGNHDELIAKRGVYNDLVQAQLLESHDDHEELPPLAARQLSQELSPLH--------SYA 1849
E GNHDEL+ ++G+Y LV Q + + E AA + E+ L S
Sbjct: 611 EKGNHDELMKEKGIYFKLVTMQTAGNEIELEN----AADESKSEIDTLEMSSHDSGSSLI 666
Query: 1848 IQRSTSNDA-GVHDDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGV 1672
+RST G D + E E + I+K ++ + + VF + I G
Sbjct: 667 RKRSTRRSVRGSQGQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGG 726
Query: 1671 SYPILAQLIVRTYEGFAM--IGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQ 1498
P A + + F E S+L++L F+ L + +T + Q + FGK E
Sbjct: 727 LQPAFAVIFSKIIGIFTRNDDAETKRQNSNLFSLLFLVLGIVSFITFFLQGFTFGKAGEI 786
Query: 1497 LSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAI 1318
L+ RLR F ML +++DDP ++ L+ RL D++ VK A+ RL + + +
Sbjct: 787 LTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAIITQNIANL 846
Query: 1317 SIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALEN 1138
I + +Y W++TL +L P +D E + + A EA+EN
Sbjct: 847 GTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIEN 906
Query: 1137 VRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYL 958
RTV +L E K + + LQ +++ ++A I G + + F Y+ F+FG YL
Sbjct: 907 FRTVVSLTQEQKFEHMYDQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYL 966
Query: 957 ALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKA-VHAAGLIFHLFTYPATMPFSS 781
++ D LV + A G +++ PDY KA V AA +I + P +S+
Sbjct: 967 VAHSLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKVSAAHIIMIIEKTPLIDSYST 1026
Query: 780 SDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLL 601
K N +G + V F+Y R D +L G++L+V G+TLALVG SGCGKST++ LL
Sbjct: 1027 EGLKPNTLEGNVTFNEVVFNYPTRLDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLL 1086
Query: 600 ERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYG-LTRSVPQL 424
ERFY + G+V +D + ++ +N+ LR++L +VSQEP LF+CSI EN+ YG +R V Q
Sbjct: 1087 ERFYDPLAGKVLLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSISENIAYGDNSRVVSQE 1146
Query: 423 ELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEAT 244
E+ +A + AN F+ P T VG++G QLSGGQKQRIAIARA++R P +LLLDEAT
Sbjct: 1147 EIVRAAKEANIHAFIESLPNKYSTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEAT 1206
Query: 243 SALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRK 64
SALD++SEKVVQ ALD A E + +V+AHRLST+ NAD I V +NG+V E GTH++LL +
Sbjct: 1207 SALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQ 1266
Query: 63 RSIYWRLVQKQ 31
+ IY+ +V Q
Sbjct: 1267 KGIYFSMVSVQ 1277
Score = 322 bits (825), Expect = 4e-86
Identities = 190/516 (36%), Positives = 289/516 (55%), Gaps = 5/516 (0%)
Frame = -1
Query: 1536 YCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVD 1357
Y Q ++ + + ++R + F ++ ++D H L+ RL D S + +
Sbjct: 133 YIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDV--HDVGELNTRLTDDVSKINEGIG 190
Query: 1356 DRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAF 1177
D++G ++ WK+TL +L P ++ +A+
Sbjct: 191 DKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAY 250
Query: 1176 ENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFL 997
+ A E L +RTV A + K + +++L++ + K+AI + G +
Sbjct: 251 AKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIY 310
Query: 996 FVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFH 817
Y+++F +GT L L KE + V ++ + A G A+ + + A AA IF
Sbjct: 311 ASYALAFWYGTTLVLSKEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAFEIFK 370
Query: 816 LF-TYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVG 640
+ P+ +S S K + KG + NV F Y R + IL G+NLKV G+T+ALVG
Sbjct: 371 IIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVG 430
Query: 639 PSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIREN 460
SGCGKST + L++R Y +G V +D +++ IN+ LR + +VSQEP LF +I EN
Sbjct: 431 NSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAEN 490
Query: 459 LLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAIL 280
+ YG V E+EKA++ ANA++F+ + PQ DTLVGERGAQLSGGQKQRIAIARA++
Sbjct: 491 IRYG-REDVTMDEIEKAVKEANAYDFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALV 549
Query: 279 RNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKV 100
RNPK+LLLDEATSALD++SE VVQ ALD A + +T+V+AHRLSTV NAD IA +G +
Sbjct: 550 RNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVI 609
Query: 99 AEQGTHEELLRKRSIYWRLVQKQ----GIQVETPSD 4
E+G H+EL++++ IY++LV Q I++E +D
Sbjct: 610 VEKGNHDELMKEKGIYFKLVTMQTAGNEIELENAAD 645
>gi|126928|sp|P21449|MDR2_CRIGR Multidrug resistance protein 2
(P-glycoprotein 2)
gi|191167|gb|AAA68884.1| p-glycoprotein isoform II
Length = 1276
Score = 743 bits (1918), Expect = 0.0
Identities = 450/1242 (36%), Positives = 681/1242 (54%), Gaps = 58/1242 (4%)
Frame = -1
Query: 3588 VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVL----------VTITNAINN 3439
+F+ + +K +LG L +++ G P + FG ++ +T + INN
Sbjct: 39 MFRYADWLDKLYMVLGTLAAVLHGTSLPLLMLVFGNMTDSFTKAETSIWPNMTNQSEINN 98
Query: 3438 KTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYI 3259
+ LE+ Y +++ G I A +Q + ++R+++
Sbjct: 99 TEVISGSLEEDMATY-------AYYYTGIGAGVLIVAYIQVSFWCLAAGRQINKIRQKFF 151
Query: 3258 SRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDW 3079
++ ++ +FD G L+T L D++ + + +KI + + F + F + W
Sbjct: 152 HAIMNQEIGWFDVHDIGELNTRLTDDVSKINDGIGDKIGMFFQSIATFLAAFIVGFISGW 211
Query: 3078 RLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKT 2899
+L + S I S + + + T K+ YA AG++A + L A +TV + GQ
Sbjct: 212 KLTLVILAVSPLIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRTVIAFGGQNK 271
Query: 2898 EIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYS--------- 2746
E+ERY + L+ + GI++A+ +IS G+ Y + + + G +++ S
Sbjct: 272 ELERYNKNLEEAKNVGIKKAVTANISIGIAYLLVYASYALAFWYGTSLVLSNEYSVGQVL 331
Query: 2745 --------GTL--------------------ETAVVVRDDNVIEKDETDYDVEVEVNGNI 2650
GT E ++ ++ I+ T V GN+
Sbjct: 332 TVFFSILFGTFSIGHIAPNIEVFANARGAAYEIFKIIDNEPSIDSFSTQGHKPDSVMGNL 391
Query: 2649 SFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIF 2470
FKNV FSYP+R ++LKG++ VQ+G+ +ALVG SG GKST VQLL Y+ G +
Sbjct: 392 EFKNVHFSYPSRSGIKILKGLNLKVQSGQTVALVGKSGCGKSTTVQLLQRLYDPTEGVVS 451
Query: 2469 IDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDF 2290
IDG D+ +N++ LR +IGVVSQEPVLF TTI ENIR+G NV++ EI A+++ANAYDF
Sbjct: 452 IDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDF 511
Query: 2289 VCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKA 2110
+ P T+VGERG QLSGGQKQRIAIAR LVRNPKILLLDEATSALD ESE VVQ A
Sbjct: 512 IMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAA 571
Query: 2109 LENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQL-- 1936
L+ A +GRTTIV+AHRLST+RNA I G IVE GNH+EL+ ++G+Y LV Q
Sbjct: 572 LDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEELMKEKGIYCRLVMMQTRG 631
Query: 1935 ----LESHDDHEELPPLAARQLSQELSPLHSYAIQRSTSND-AGVHDDDMERILDELSKE 1771
L S D + +A+ S+E S ++++ST G D + + E E
Sbjct: 632 NEVELGSEADGSQSDTIASELTSEEFK---SPSVRKSTCRSICGSQDQERRVSVKEAQDE 688
Query: 1770 GAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYYS 1591
+ I+K ++ +L + V + I G P+ + + F +
Sbjct: 689 DVPLVSFWGILKLNITEWPYLVVGVLCAVINGCMQPVFSIVFSGIIGVFTRDDDPKTKQQ 748
Query: 1590 --HLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHS 1417
+L++L F+ + + +T + Q + FGK E L+ RLR F ML +++DD +S
Sbjct: 749 NCNLFSLFFLVMGMICFVTYFFQGFTFGKAGEILTKRLRYMVFKSMLRQDISWFDDHRNS 808
Query: 1416 ATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXX 1237
L+ RL +D++NVK A+ RL + V + I + +Y W++TL +++ P
Sbjct: 809 TGALTTRLASDAANVKGAMSSRLAGITQNVANLGTGIIISLVYGWQLTLLLVVIAPLIIL 868
Query: 1236 XXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKS 1057
+D E S + A EA+EN RTV +L E K ++ ++ LQ +++
Sbjct: 869 SGMMEMKVLSGQALKDKKELEVSGKIATEAIENFRTVVSLTREQKFENMYAQSLQIPYRN 928
Query: 1056 YFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGS 877
K+A + G + + F Y+ F+FG YL + + + LV + A AG+
Sbjct: 929 ALKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVAHQIMTFENVMLVFSAVVFGAIAAGN 988
Query: 876 AAAYLPDYKKA-VHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDR 700
A+++ PDY KA V A+ +I + P+ +S+ K N +G + V F+Y RPD
Sbjct: 989 ASSFAPDYAKAKVSASHIIRIMEKIPSIDSYSTRGLKPNWLEGNVKFNEVVFNYPTRPDI 1048
Query: 699 MILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLR 520
+L G++L+V G+TLALVG SGCGKST++ LLERFY + G V +D + ++ +N+ LR
Sbjct: 1049 PVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEIKQLNVQWLR 1108
Query: 519 SNLALVSQEPTLFNCSIRENLLYG-LTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVG 343
++L +VSQEP LF+CSI EN+ YG +R V Q E+E+A + AN F+ P +T VG
Sbjct: 1109 AHLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIERAAKEANIHQFIESLPDKYNTRVG 1168
Query: 342 ERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVV 163
++G QLSGGQKQRIAIARA++R P +LLLDEATSALD++SEKVVQ ALD A E + +V+
Sbjct: 1169 DKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVI 1228
Query: 162 AHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQ 37
AHRLST+ NAD I V++NGKV E GTH++LL ++ IY+ +VQ
Sbjct: 1229 AHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVQ 1270
Score = 326 bits (835), Expect = 3e-87
Identities = 194/517 (37%), Positives = 288/517 (55%), Gaps = 3/517 (0%)
Frame = -1
Query: 1545 LTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKA 1366
+ Y Q ++ + + ++R K F +++ ++D H L+ RL D S +
Sbjct: 126 IVAYIQVSFWCLAAGRQINKIRQKFFHAIMNQEIGWFDV--HDIGELNTRLTDDVSKIND 183
Query: 1365 AVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDT 1186
+ D++G ++ A + WK+TL +L P ++
Sbjct: 184 GIGDKIGMFFQSIATFLAAFIVGFISGWKLTLVILAVSPLIGLSSAMWAKVLTSFTNKEL 243
Query: 1185 IAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLS 1006
A+ + A E L +RTV A ++K + +++L++ K+A+ + G++
Sbjct: 244 QAYAKAGAVAEEVLAAIRTVIAFGGQNKELERYNKNLEEAKNVGIKKAVTANISIGIAYL 303
Query: 1005 CFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGL 826
Y+++F +GT L L E + V ++ G A + + A AA
Sbjct: 304 LVYASYALAFWYGTSLVLSNEYSVGQVLTVFFSILFGTFSIGHIAPNIEVFANARGAAYE 363
Query: 825 IFHLF-TYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLA 649
IF + P+ FS+ K + G + +NV F Y R IL G+NLKV G+T+A
Sbjct: 364 IFKIIDNEPSIDSFSTQGHKPDSVMGNLEFKNVHFSYPSRSGIKILKGLNLKVQSGQTVA 423
Query: 648 LVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSI 469
LVG SGCGKST + LL+R Y +G V ID +++ IN+ +LR + +VSQEP LF +I
Sbjct: 424 LVGKSGCGKSTTVQLLQRLYDPTEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTI 483
Query: 468 RENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIAR 289
EN+ YG +V E+EKA++ ANA++F+ + P DTLVGERGAQLSGGQKQRIAIAR
Sbjct: 484 AENIRYG-RENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIAR 542
Query: 288 AILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKN 109
A++RNPK+LLLDEATSALD++SE VVQ ALD A E +T+V+AHRLSTV NAD IA
Sbjct: 543 ALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDG 602
Query: 108 GKVAEQGTHEELLRKRSIYWRLV--QKQGIQVETPSD 4
G + EQG HEEL++++ IY RLV Q +G +VE S+
Sbjct: 603 GVIVEQGNHEELMKEKGIYCRLVMMQTRGNEVELGSE 639
Score = 304 bits (779), Expect = 9e-81
Identities = 193/577 (33%), Positives = 305/577 (52%), Gaps = 41/577 (7%)
Frame = -1
Query: 3549 LLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQVV 3370
++GVL +++ G QP S F S ++ T + KT ++ N
Sbjct: 710 VVGVLCAVINGCMQPVFSIVF---SGIIGVFTRDDDPKT------------KQQNCNLFS 754
Query: 3369 FHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSV--STGHLST 3196
F + G F+ Q G+ T R+R +L++D +FD STG L+T
Sbjct: 755 LFFLVMGMICFVTYFFQGFTFGKAGEILTKRLRYMVFKSMLRQDISWFDDHRNSTGALTT 814
Query: 3195 VLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINS 3016
L + + + ++A I V + G ++ W+L + + I SG +
Sbjct: 815 RLASDAANVKGAMSSRLAGITQNVANLGTGIIISLVYGWQLTLLLVVIAPLIILSGMMEM 874
Query: 3015 AGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRA- 2839
+ K +G IA + + ++TV SL ++ Y + L+ + +++A
Sbjct: 875 KVLSGQALKDKKELEVSGKIATEAIENFRTVVSLTREQKFENMYAQSLQIPYRNALKKAH 934
Query: 2838 ---LMYSISRGVTYFFCNSL---------NTVVLYVGATMIYSGTLETAVVVRDDNVIEK 2695
+ +S ++ + YF + + ++ + +++S + A+ + +
Sbjct: 935 VFGITFSFTQAMMYFSYAACFRFGAYLVAHQIMTFENVMLVFSAVVFGAIAAGNASSFAP 994
Query: 2694 DETDYDVEVE------------------------VNGNISFKNVKFSYPTRPDAQVLKGI 2587
D V + GN+ F V F+YPTRPD VL+G+
Sbjct: 995 DYAKAKVSASHIIRIMEKIPSIDSYSTRGLKPNWLEGNVKFNEVVFNYPTRPDIPVLQGL 1054
Query: 2586 SFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVV 2407
S +V+ G+ +ALVG+SG GKSTVVQLL +Y+ +G +F+DG ++ +N++ LR +G+V
Sbjct: 1055 SLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEIKQLNVQWLRAHLGIV 1114
Query: 2406 SQEPVLFNTTIEENIRFGNPN--VSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQL 2233
SQEP+LF+ +I ENI +G+ + VS EI A ++AN + F+ S P T VG++GTQL
Sbjct: 1115 SQEPILFDCSIAENIAYGDNSRVVSQDEIERAAKEANIHQFIESLPDKYNTRVGDKGTQL 1174
Query: 2232 SGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLST 2053
SGGQKQRIAIAR LVR P ILLLDEATSALD ESE+VVQ+AL+ A +GRT IV+AHRLST
Sbjct: 1175 SGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLST 1234
Query: 2052 IRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQA 1942
I+NA I+V+Q G++ E G H +L+A++G+Y +VQA
Sbjct: 1235 IQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVQA 1271
>gi|22775296|gb|AAN07779.1| multidrug resistance p-glycoprotein
[Macaca mulatta]
Length = 1283
Score = 743 bits (1917), Expect = 0.0
Identities = 450/1271 (35%), Positives = 674/1271 (52%), Gaps = 57/1271 (4%)
Frame = -1
Query: 3672 ENSNNFSTPLLPQSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSY 3493
E N F + D+K+ S + F+ S+ +K ++G+L +++ G P M
Sbjct: 12 EKKNFFKLNNKSKKDKKERKPTVSVFSM-FRYSNWLDKLYMVVGILAAIIHGAGLPLMML 70
Query: 3492 TFGEVSQVLVTITNA-------INNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFI 3334
FG+++ N NN E M + +++ G +
Sbjct: 71 VFGDMTDTFANAGNLGDLGALLFNNTNSSNITDTVPVMNLEEDMTRYAYYYSGIGAGVLV 130
Query: 3333 FASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFN 3154
A +Q + +++RKQ+ +++++ +FD G L+T L D++ + E
Sbjct: 131 AAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIG 190
Query: 3153 EKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHY 2974
+KI + + F G + F W+L + S + S + + T K+ Y
Sbjct: 191 DKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGVSAAAWAKILSSFTDKELLAY 250
Query: 2973 ANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCN 2794
A AG++A + L A +TV + GQK E+ERY + L+ ++ GI++A+ +IS G +
Sbjct: 251 AKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIY 310
Query: 2793 SLNTVVLYVGATMIYS-------------------------------------GTLETAV 2725
+ + + G T++ S E
Sbjct: 311 ASYALAFWYGTTLVLSKEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAFEIFK 370
Query: 2724 VVRDDNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVG 2545
++ + I+ + GN+ F+NV FSYP+R + ++LKG++ VQ+G+ +ALVG
Sbjct: 371 IIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVG 430
Query: 2544 ASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEEN 2365
SG GKST VQL+ Y+ G + +DG D+ +N++ LR +IGVVSQEPVLF TTI EN
Sbjct: 431 NSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAEN 490
Query: 2364 IRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVR 2185
IR+G +V++ EI A+++ANAYDF+ P+ T+VGERG QLSGGQKQRIAIAR LVR
Sbjct: 491 IRYGREDVTMDEIEKAVKEANAYDFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVR 550
Query: 2184 NPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIV 2005
NPKILLLDEATSALD ESE VVQ AL+ A +GRTTIV+AHRLST+RNA I G IV
Sbjct: 551 NPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIV 610
Query: 2004 EVGNHDELIAKRGVYNDLVQAQLLESHDDHEELPPLAARQLSQELSPLH--------SYA 1849
E GNHDEL+ ++G+Y LV Q + + E AA + E+ L S
Sbjct: 611 EKGNHDELMKEKGIYFKLVTMQTAGNEIELEN----AADESKSEIDTLEMSSHDSGSSLI 666
Query: 1848 IQRSTSNDA-GVHDDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGV 1672
+RST G D + E E + I+K ++ + + VF + I G
Sbjct: 667 RKRSTRRSVRGSQGQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGG 726
Query: 1671 SYPILAQLIVRTYEGFAM--IGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQ 1498
P A + + F E S+L++L F+ L + +T + Q + FGK E
Sbjct: 727 LQPAFAVIFSKIIGIFTRNDDAETKRQNSNLFSLLFLVLGIVSFITFFLQGFTFGKAGEI 786
Query: 1497 LSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAI 1318
L+ RLR F ML +++DDP ++ L+ RL D++ VK A+ RL + + +
Sbjct: 787 LTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAIITQNIANL 846
Query: 1317 SIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALEN 1138
I + +Y W++TL +L P +D E + + A EA+EN
Sbjct: 847 GTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIEN 906
Query: 1137 VRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYL 958
RTV +L E K + + LQ +++ ++A I G + + F Y+ F+FG YL
Sbjct: 907 FRTVVSLTQEQKFEHMYDQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYL 966
Query: 957 ALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKA-VHAAGLIFHLFTYPATMPFSS 781
++ D LV + A G +++ PDY KA V AA +I + P +S+
Sbjct: 967 VAHSLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKVSAAHIIMIIEKTPLIDSYST 1026
Query: 780 SDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLL 601
K N +G + V F+Y R D +L G++L+V G+TLALVG SGCGKST++ LL
Sbjct: 1027 EGLKPNTLEGNVTFNEVVFNYPTRLDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLL 1086
Query: 600 ERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYG-LTRSVPQL 424
ERFY + G+V +D + ++ +N+ LR++L +VSQEP LF+CSI EN+ YG +R V Q
Sbjct: 1087 ERFYDPLAGKVLLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSISENIAYGDNSRVVSQE 1146
Query: 423 ELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEAT 244
E+ +A + AN F+ P T VG++G QLSGGQKQRIAIARA++R P +LLLDEAT
Sbjct: 1147 EIVRAAKEANIHAFIESLPNKYSTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEAT 1206
Query: 243 SALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRK 64
SALD++SEKVVQ ALD A E + +V+AHRLST+ NAD I V +NG+V E GTH++LL +
Sbjct: 1207 SALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQ 1266
Query: 63 RSIYWRLVQKQ 31
+ IY+ +V Q
Sbjct: 1267 KGIYFSMVSVQ 1277
Score = 322 bits (826), Expect = 3e-86
Identities = 190/516 (36%), Positives = 289/516 (55%), Gaps = 5/516 (0%)
Frame = -1
Query: 1536 YCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVD 1357
Y Q ++ + + ++R + F ++ ++D H L+ RL D S + +
Sbjct: 133 YIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDV--HDVGELNTRLTDDVSKINEGIG 190
Query: 1356 DRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAF 1177
D++G ++ WK+TL +L P ++ +A+
Sbjct: 191 DKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGVSAAAWAKILSSFTDKELLAY 250
Query: 1176 ENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFL 997
+ A E L +RTV A + K + +++L++ + K+AI + G +
Sbjct: 251 AKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIY 310
Query: 996 FVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFH 817
Y+++F +GT L L KE + V ++ + A G A+ + + A AA IF
Sbjct: 311 ASYALAFWYGTTLVLSKEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAFEIFK 370
Query: 816 LF-TYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVG 640
+ P+ +S S K + KG + NV F Y R + IL G+NLKV G+T+ALVG
Sbjct: 371 IIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVG 430
Query: 639 PSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIREN 460
SGCGKST + L++R Y +G V +D +++ IN+ LR + +VSQEP LF +I EN
Sbjct: 431 NSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAEN 490
Query: 459 LLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAIL 280
+ YG V E+EKA++ ANA++F+ + PQ DTLVGERGAQLSGGQKQRIAIARA++
Sbjct: 491 IRYG-REDVTMDEIEKAVKEANAYDFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALV 549
Query: 279 RNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKV 100
RNPK+LLLDEATSALD++SE VVQ ALD A + +T+V+AHRLSTV NAD IA +G +
Sbjct: 550 RNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVI 609
Query: 99 AEQGTHEELLRKRSIYWRLVQKQ----GIQVETPSD 4
E+G H+EL++++ IY++LV Q I++E +D
Sbjct: 610 VEKGNHDELMKEKGIYFKLVTMQTAGNEIELENAAD 645
>gi|2852441|gb|AAC02113.1| multidrug resistance p-glycoprotein [Canis
familiaris]
Length = 1280
Score = 742 bits (1915), Expect = 0.0
Identities = 446/1263 (35%), Positives = 680/1263 (53%), Gaps = 61/1263 (4%)
Frame = -1
Query: 3636 QSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVL--- 3466
+ EKKP+ + +F +F+ S+ ++ L+G + +++ G P M FG ++
Sbjct: 25 EKKEKKPT-VSTF--AMFRYSNWLDRLYMLVGTMAAIIHGAALPLMMLVFGNMTDSFANA 81
Query: 3465 ---------VTITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHA 3313
V I +I N T + E M +++ G + A +Q +
Sbjct: 82 GISRNKTFPVIINESITNNT------QHFINHLEEEMTTYAYYYSGIGAGVLVAAYIQVS 135
Query: 3312 IMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALII 3133
++RKQ+ +++++ +FD G L+T L D++ + E +K+ +
Sbjct: 136 FWCLAAGRQILKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKVGMFF 195
Query: 3132 AFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIA 2953
+ F G + F W+L + S + S I + + T K+ YA AG++A
Sbjct: 196 QSIATFFTGFIVGFTPGWKLTLVILAISPVLGLSAAIWAKILSSFTDKELLAYAKAGAVA 255
Query: 2952 FQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVL 2773
+ L A +TV + GQK E+ERY + L+ ++ GI++A+ +IS G + + +
Sbjct: 256 EEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAF 315
Query: 2772 YVGATMIYSG-------------------------------------TLETAVVVRDDNV 2704
+ G +++ S E ++ +
Sbjct: 316 WYGTSLVLSSEYTIGQVLTVFFSVLIGAFSIGQASPSIEAFANARGAAYEIFKIIDNKPS 375
Query: 2703 IEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKS 2524
I+ + GN+ FKNV FSYP+R + ++LKG++ VQ+G+ +ALVG SG GKS
Sbjct: 376 IDSYSKSGHKPDNIKGNLEFKNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKS 435
Query: 2523 TVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPN 2344
T VQL+ Y+ G + IDG D+ +N++ LR + GVVSQEPVLF TTI ENIR+G N
Sbjct: 436 TTVQLMQRLYDPTDGMVCIDGQDIRTINVRHLREITGVVSQEPVLFATTIAENIRYGREN 495
Query: 2343 VSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLL 2164
V++ EI A+++ANAYDF+ P T+VGERG +LSGGQKQRIAIAR LVRNPKILLL
Sbjct: 496 VTMDEIEKAVKEANAYDFIMKLPNKFDTLVGERGARLSGGQKQRIAIARALVRNPKILLL 555
Query: 2163 DEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDE 1984
DEATSALD ESE VVQ AL+ A +GRTTIV+AHRLST+RNA I G IVE GNHDE
Sbjct: 556 DEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDE 615
Query: 1983 LIAKRGVYNDLVQAQLLESHDDHEELPPLAARQLSQ----ELSPLHS-YAIQRSTSNDAG 1819
L+ ++G+Y LV +++ + EL S+ E+SP S ++ + S
Sbjct: 616 LMKEKGIYFKLV---TMQTRGNEIELENATGESKSESDALEMSPKDSGSSLIKRRSTRRS 672
Query: 1818 VH---DDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQL 1648
+H D + E E + I+K ++ + + +F + I G P + +
Sbjct: 673 IHAPQGQDRKLGTKEDLNENVPSVSFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSII 732
Query: 1647 IVRTYEGFAM--IGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIK 1474
R F E S+++++ F+ L + +T + Q + FGK E L+ RLR
Sbjct: 733 FSRIIGIFTRDEDPETKRQNSNMFSVLFLVLGIISFITFFLQGFTFGKAGEILTKRLRYM 792
Query: 1473 SFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTAS 1294
F ML +++DDP ++ L+ RL D++ VK A+ RL + + + I +
Sbjct: 793 VFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISL 852
Query: 1293 LYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALN 1114
+Y W++TL +L P +D E + + A EA+EN RTV +L
Sbjct: 853 IYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLT 912
Query: 1113 LEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAP 934
E K + ++ LQ +++ ++A I G + ++ + F Y+ F+FG YL + +
Sbjct: 913 REQKFEYMYAQSLQVPYRNSLRKAHIFGVSFSITQAMMYFSYAGCFRFGAYLVANEFMNF 972
Query: 933 MDTYLVLMTLSMTANMAGSAAAYLPDYKKA-VHAAGLIFHLFTYPATMPFSSSDGKKNIE 757
D LV + A G +++ PDY KA V AA +I + P +S K N
Sbjct: 973 QDVLLVFSAIVFGAMAVGQVSSFAPDYAKAKVSAAHVIMIIEKSPLIDSYSPHGLKPNTL 1032
Query: 756 KGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVD 577
+G + V F+Y RPD +L G++L+V G+TLALVG SGCGKST++ LLERFY +
Sbjct: 1033 EGNVTFNEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLA 1092
Query: 576 GEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYG-LTRSVPQLELEKALQT 400
G V ID + ++ +N+ LR++L +VSQEP LF+CSI EN+ YG +R V E+ +A +
Sbjct: 1093 GSVLIDGKEIKHLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSHEEIMQAAKE 1152
Query: 399 ANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSE 220
AN +F+ P+ +T VG++G QLSGGQKQRIAIARA++R P +LLLDEATSALD++SE
Sbjct: 1153 ANIHHFIETLPEKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESE 1212
Query: 219 KVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLV 40
KVVQ ALD A E + +V+AHRLST+ NAD I V +NGKV E GTH++LL ++ IY+ ++
Sbjct: 1213 KVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGKVKEHGTHQQLLAQKGIYFSMI 1272
Query: 39 QKQ 31
Q
Sbjct: 1273 SVQ 1275
Score = 320 bits (821), Expect = 1e-85
Identities = 189/510 (37%), Positives = 287/510 (56%), Gaps = 3/510 (0%)
Frame = -1
Query: 1536 YCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVD 1357
Y Q ++ + + ++R + F ++ ++D H L+ RL D S + +
Sbjct: 131 YIQVSFWCLAAGRQILKIRKQFFHAIMRQEIGWFDV--HDVGELNTRLTDDVSKINEGIG 188
Query: 1356 DRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAF 1177
D++G ++ WK+TL +L P ++ +A+
Sbjct: 189 DKVGMFFQSIATFFTGFIVGFTPGWKLTLVILAISPVLGLSAAIWAKILSSFTDKELLAY 248
Query: 1176 ENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFL 997
+ A E L +RTV A + K + +++L++ + K+AI + G +
Sbjct: 249 AKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIY 308
Query: 996 FVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFH 817
Y+++F +GT L L E V ++ + A G A+ + + A AA IF
Sbjct: 309 ASYALAFWYGTSLVLSSEYTIGQVLTVFFSVLIGAFSIGQASPSIEAFANARGAAYEIFK 368
Query: 816 LF-TYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVG 640
+ P+ +S S K + KG + +NV F Y R + IL G+NLKV G+T+ALVG
Sbjct: 369 IIDNKPSIDSYSKSGHKPDNIKGNLEFKNVHFSYPSRKEVKILKGLNLKVQSGQTVALVG 428
Query: 639 PSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIREN 460
SGCGKST + L++R Y DG V ID +++ IN+ HLR +VSQEP LF +I EN
Sbjct: 429 NSGCGKSTTVQLMQRLYDPTDGMVCIDGQDIRTINVRHLREITGVVSQEPVLFATTIAEN 488
Query: 459 LLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAIL 280
+ YG +V E+EKA++ ANA++F+ + P DTLVGERGA+LSGGQKQRIAIARA++
Sbjct: 489 IRYG-RENVTMDEIEKAVKEANAYDFIMKLPNKFDTLVGERGARLSGGQKQRIAIARALV 547
Query: 279 RNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKV 100
RNPK+LLLDEATSALD++SE VVQ ALD A + +T+V+AHRLSTV NAD IA +G +
Sbjct: 548 RNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVI 607
Query: 99 AEQGTHEELLRKRSIYWRLV--QKQGIQVE 16
E+G H+EL++++ IY++LV Q +G ++E
Sbjct: 608 VEKGNHDELMKEKGIYFKLVTMQTRGNEIE 637
>gi|22759019|gb|AAN05645.1| multidrug resistance p-glycoprotein [Canis
familiaris]
Length = 1281
Score = 742 bits (1915), Expect = 0.0
Identities = 449/1263 (35%), Positives = 679/1263 (53%), Gaps = 61/1263 (4%)
Frame = -1
Query: 3636 QSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVL--- 3466
+ EKKP+ + +F +F+ S+ ++ L+G + +++ G P M FG ++
Sbjct: 26 EKKEKKPT-VSTF--AMFRYSNWLDRLYMLVGTMAAIIHGAALPLMMLVFGNMTDSFANA 82
Query: 3465 ---------VTITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHA 3313
V I +I N T + E M +++ G + A +Q +
Sbjct: 83 GISRNKAFPVIINESITNNT------QHFINHLEEEMTTYAYYYSGIGAGVLVAAYIQVS 136
Query: 3312 IMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALII 3133
++RKQ+ +++++ +FD G L+T L D++ + E +KI +
Sbjct: 137 FWCLAAGRQILKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFF 196
Query: 3132 AFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIA 2953
+ F G + F W+L + S + S I + + T K+ YA AG++A
Sbjct: 197 HSIATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAIWAKILSSFTDKELLAYAKAGAVA 256
Query: 2952 FQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVL 2773
+ L A +TV + GQK E+ERY + L+ + GI++A+ +IS G + + +
Sbjct: 257 EEVLAAIRTVIAFGGQKKELERYNKNLEEAKGIGIKKAITANISIGAAFLLIYASYALAF 316
Query: 2772 YVGATMIYSG-------------------------------------TLETAVVVRDDNV 2704
+ G +++ S E ++ +
Sbjct: 317 WYGTSLVLSSEYSIGQVLTVFFSVLIGAFSIGQASPSIEAFANARGAAYEIFKIIDNKPS 376
Query: 2703 IEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKS 2524
I+ + GN+ FKNV FSYP+R + ++LKG++ VQ+G+ +ALVG SG GKS
Sbjct: 377 IDSYSKSGHKPDNIKGNLEFKNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKS 436
Query: 2523 TVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPN 2344
T VQL+ Y+ G + IDG D+ +N++ LR + GVVSQEPVLF TTI ENIR+G N
Sbjct: 437 TTVQLMQRLYDPTDGMVCIDGQDIRTINVRHLREITGVVSQEPVLFATTIAENIRYGREN 496
Query: 2343 VSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLL 2164
V++ EI A+++ANAYDF+ P T+VGERG QLSGGQKQRIAIAR LVRNPKILLL
Sbjct: 497 VTMDEIEKAVKEANAYDFIMKLPNKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLL 556
Query: 2163 DEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDE 1984
DEATSALD ESE VVQ AL+ A +GRTTIV+AHRLST+RNA I G IVE GNHDE
Sbjct: 557 DEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDE 616
Query: 1983 LIAKRGVYNDLVQAQLLESHDDHEELPPLAARQLSQ----ELSPLHS-YAIQRSTSNDAG 1819
L+ ++G+Y LV +++ + EL S+ E+SP S ++ + S
Sbjct: 617 LMKEKGIYFKLV---TMQTRGNEIELENATGESKSESDALEMSPKDSGSSLIKRRSTRRS 673
Query: 1818 VH---DDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQL 1648
+H D + E E + I+K ++ + + +F + I G P + +
Sbjct: 674 IHAPQGQDRKLGTKEDLNENVPPVSFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSII 733
Query: 1647 IVRTYEGFAM--IGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIK 1474
R F E S+++++ F+ L + +T + Q + FGK E L+ RLR
Sbjct: 734 FSRIIGIFTRDEDPETKRQNSNMFSVLFLVLGIISFITFFLQGFTFGKAGEILTKRLRYM 793
Query: 1473 SFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTAS 1294
F ML +++DDP ++ L+ RL D++ VK A+ RL + + + I +
Sbjct: 794 VFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISL 853
Query: 1293 LYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALN 1114
+Y W++TL +L P +D E + + A EA+EN RTV +L
Sbjct: 854 IYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLT 913
Query: 1113 LEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAP 934
E K + ++ LQ +++ ++A I G + ++ + F Y+ F+FG YL + +
Sbjct: 914 REQKFEYMYAQSLQVPYRNSLRKAHIFGVSFSITQAMMYFSYAGCFRFGAYLVANEFMNF 973
Query: 933 MDTYLVLMTLSMTANMAGSAAAYLPDYKKA-VHAAGLIFHLFTYPATMPFSSSDGKKNIE 757
D LV + A G +++ PDY KA V AA +I + P +S K N
Sbjct: 974 QDVLLVFSAIVFGAMAVGQVSSFAPDYAKAKVSAAHVIMIIEKSPLIDSYSPHGLKPNTL 1033
Query: 756 KGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVD 577
+G + V F+Y RPD +L G++L+V G+TLALVG SGCGKST++ LLERFY +
Sbjct: 1034 EGNVTFNEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLA 1093
Query: 576 GEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYG-LTRSVPQLELEKALQT 400
G V ID + ++ +N+ LR++L +VSQEP LF+CSI EN+ YG +R V E+ +A +
Sbjct: 1094 GSVLIDGKEIKHLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSHEEIMQAAKE 1153
Query: 399 ANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSE 220
AN +F+ P+ +T VG++G QLSGGQKQRIAIARA++R P +LLLDEATSALD++SE
Sbjct: 1154 ANIHHFIETLPEKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESE 1213
Query: 219 KVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLV 40
KVVQ ALD A E + +V+AHRLST+ NAD I V +NGKV E GTH++LL ++ IY+ +V
Sbjct: 1214 KVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGKVKEHGTHQQLLAQKGIYFSMV 1273
Query: 39 QKQ 31
Q
Sbjct: 1274 SVQ 1276
Score = 321 bits (822), Expect = 9e-86
Identities = 190/510 (37%), Positives = 287/510 (56%), Gaps = 3/510 (0%)
Frame = -1
Query: 1536 YCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVD 1357
Y Q ++ + + ++R + F ++ ++D H L+ RL D S + +
Sbjct: 132 YIQVSFWCLAAGRQILKIRKQFFHAIMRQEIGWFDV--HDVGELNTRLTDDVSKINEGIG 189
Query: 1356 DRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAF 1177
D++G ++ WK+TL +L P ++ +A+
Sbjct: 190 DKIGMFFHSIATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAIWAKILSSFTDKELLAY 249
Query: 1176 ENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFL 997
+ A E L +RTV A + K + +++L++ K+AI + G +
Sbjct: 250 AKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKGIGIKKAITANISIGAAFLLIY 309
Query: 996 FVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFH 817
Y+++F +GT L L E + V ++ + A G A+ + + A AA IF
Sbjct: 310 ASYALAFWYGTSLVLSSEYSIGQVLTVFFSVLIGAFSIGQASPSIEAFANARGAAYEIFK 369
Query: 816 LF-TYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVG 640
+ P+ +S S K + KG + +NV F Y R + IL G+NLKV G+T+ALVG
Sbjct: 370 IIDNKPSIDSYSKSGHKPDNIKGNLEFKNVHFSYPSRKEVKILKGLNLKVQSGQTVALVG 429
Query: 639 PSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIREN 460
SGCGKST + L++R Y DG V ID +++ IN+ HLR +VSQEP LF +I EN
Sbjct: 430 NSGCGKSTTVQLMQRLYDPTDGMVCIDGQDIRTINVRHLREITGVVSQEPVLFATTIAEN 489
Query: 459 LLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAIL 280
+ YG +V E+EKA++ ANA++F+ + P DTLVGERGAQLSGGQKQRIAIARA++
Sbjct: 490 IRYG-RENVTMDEIEKAVKEANAYDFIMKLPNKFDTLVGERGAQLSGGQKQRIAIARALV 548
Query: 279 RNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKV 100
RNPK+LLLDEATSALD++SE VVQ ALD A + +T+V+AHRLSTV NAD IA +G +
Sbjct: 549 RNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVI 608
Query: 99 AEQGTHEELLRKRSIYWRLV--QKQGIQVE 16
E+G H+EL++++ IY++LV Q +G ++E
Sbjct: 609 VEKGNHDELMKEKGIYFKLVTMQTRGNEIE 638
>gi|46394984|gb|AAS91648.1| multidrug resistance protein;
P-glycoprotein [Macaca mulatta]
Length = 1283
Score = 740 bits (1910), Expect = 0.0
Identities = 450/1271 (35%), Positives = 671/1271 (52%), Gaps = 57/1271 (4%)
Frame = -1
Query: 3672 ENSNNFSTPLLPQSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSY 3493
E N F + D+K+ S + F+ S+ +K ++G L +++ G P M
Sbjct: 12 EKKNFFKLNNKSKKDKKERKPTVSVFSM-FRYSNWLDKLYMVVGTLAAIIHGAGLPLMML 70
Query: 3492 TFGEVSQVLVTITNA-------INNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFI 3334
FG+++ N NN E M + +++ G +
Sbjct: 71 VFGDMTDTFANAGNLGDLGALLFNNTNSSNITDTVPVMNLEEDMTRYAYYYSGIGAGVLV 130
Query: 3333 FASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFN 3154
A +Q + +++RKQ+ +++++ +FD G L+T L D + + E
Sbjct: 131 AAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDEVSKINEGIG 190
Query: 3153 EKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHY 2974
+KI + + F G + F W+L + S + S + + T K+ Y
Sbjct: 191 DKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPILGLSAAAWAKILSSFTDKELLAY 250
Query: 2973 ANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCN 2794
A AG +A + L A +TV + GQK E+ERY + L+ ++ GI++A+ +IS G +
Sbjct: 251 AKAGVVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIY 310
Query: 2793 SLNTVVLYVGATMIYS-------------------------------------GTLETAV 2725
+ + + G T++ S E
Sbjct: 311 ASYALAFWYGTTLVLSKEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAFEIFK 370
Query: 2724 VVRDDNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVG 2545
++ + I+ + GN+ F+NV FSYP+R + ++LKG++ VQ+G+ +ALVG
Sbjct: 371 IIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVG 430
Query: 2544 ASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEEN 2365
SG GKST VQL+ Y+ G + +DG D+ +N++ LR +IGVVSQEPVLF TTI EN
Sbjct: 431 NSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAEN 490
Query: 2364 IRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVR 2185
IR+G +V++ EI A+++ANAYDF+ P+ T+VGERG QLSGGQKQRIAIAR LVR
Sbjct: 491 IRYGREDVTMDEIEKAVKEANAYDFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVR 550
Query: 2184 NPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIV 2005
NPKILLLDEATSALD ESE VVQ AL+ A +GRTTIV+AHRLST+RNA I G IV
Sbjct: 551 NPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIV 610
Query: 2004 EVGNHDELIAKRGVYNDLVQAQLLESHDDHEELPPLAARQLSQELSPLH--------SYA 1849
E GNHDEL+ ++G+Y LV Q + + E AA + E+ L S
Sbjct: 611 EKGNHDELMKEKGIYFKLVTMQTAGNEIELEN----AADESKSEIDTLEMSSHDSGSSLI 666
Query: 1848 IQRSTSNDA-GVHDDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGV 1672
+RST G D + E E + I+K ++ + + VF + I G
Sbjct: 667 RKRSTRRSVRGSQGQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGG 726
Query: 1671 SYPILAQLIVRTYEGFAM--IGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQ 1498
P A + + F E S+L++L F+ L + +T + Q + FGK E
Sbjct: 727 LQPAFAVIFSKIIGIFTRNDDAETKQQNSNLFSLLFLVLGIVSFITFFLQGFTFGKAGEI 786
Query: 1497 LSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAI 1318
L+ RLR F ML +++DDP ++ L+ RL D++ VK A+ RL + + +
Sbjct: 787 LTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAIITQNIANL 846
Query: 1317 SIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALEN 1138
I + +Y W++TL +L P +D E + + A EA+EN
Sbjct: 847 GTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIEN 906
Query: 1137 VRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYL 958
RTV +L E K + + LQ +++ ++A I G + + F Y+ F+FG YL
Sbjct: 907 FRTVVSLTQEQKFEHMYDQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYL 966
Query: 957 ALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKA-VHAAGLIFHLFTYPATMPFSS 781
++ D LV + A G +++ PDY KA V AA +I + P +S+
Sbjct: 967 VAHSLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKVSAAHIIMIIEKTPLIDSYST 1026
Query: 780 SDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLL 601
K N +G + V F+Y R D +L G++L+V G+TLALVG SGCGKST++ LL
Sbjct: 1027 EGLKPNTLEGNVTFNEVVFNYPTRLDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLL 1086
Query: 600 ERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYG-LTRSVPQL 424
ERFY + G+V +D + ++ +N+ LR++L +VSQEP LF+CSI EN+ YG +R V Q
Sbjct: 1087 ERFYDPLAGKVLLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSISENIAYGDNSRVVSQE 1146
Query: 423 ELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEAT 244
E+ +A + AN F+ P T VG++G QLSGGQKQRIAIARA++R P +LLLDEAT
Sbjct: 1147 EIVRAAKEANIHAFIESLPNKYSTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEAT 1206
Query: 243 SALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRK 64
SALD++SEKVVQ ALD A E + +V+AHRLST+ NAD I V +NG+V E GTH++LL +
Sbjct: 1207 SALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQ 1266
Query: 63 RSIYWRLVQKQ 31
+ IY+ +V Q
Sbjct: 1267 KGIYFSMVSVQ 1277
Score = 320 bits (820), Expect = 2e-85
Identities = 189/516 (36%), Positives = 289/516 (55%), Gaps = 5/516 (0%)
Frame = -1
Query: 1536 YCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVD 1357
Y Q ++ + + ++R + F ++ ++D H L+ RL + S + +
Sbjct: 133 YIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDV--HDVGELNTRLTDEVSKINEGIG 190
Query: 1356 DRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAF 1177
D++G ++ WK+TL +L P ++ +A+
Sbjct: 191 DKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPILGLSAAAWAKILSSFTDKELLAY 250
Query: 1176 ENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFL 997
+ A E L +RTV A + K + +++L++ + K+AI + G +
Sbjct: 251 AKAGVVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIY 310
Query: 996 FVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFH 817
Y+++F +GT L L KE + V ++ + A G A+ + + A AA IF
Sbjct: 311 ASYALAFWYGTTLVLSKEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAFEIFK 370
Query: 816 LF-TYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVG 640
+ P+ +S S K + KG + NV F Y R + IL G+NLKV G+T+ALVG
Sbjct: 371 IIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVG 430
Query: 639 PSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIREN 460
SGCGKST + L++R Y +G V +D +++ IN+ LR + +VSQEP LF +I EN
Sbjct: 431 NSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAEN 490
Query: 459 LLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAIL 280
+ YG V E+EKA++ ANA++F+ + PQ DTLVGERGAQLSGGQKQRIAIARA++
Sbjct: 491 IRYG-REDVTMDEIEKAVKEANAYDFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALV 549
Query: 279 RNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKV 100
RNPK+LLLDEATSALD++SE VVQ ALD A + +T+V+AHRLSTV NAD IA +G +
Sbjct: 550 RNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVI 609
Query: 99 AEQGTHEELLRKRSIYWRLVQKQ----GIQVETPSD 4
E+G H+EL++++ IY++LV Q I++E +D
Sbjct: 610 VEKGNHDELMKEKGIYFKLVTMQTAGNEIELENAAD 645
>gi|39594784|emb|CAE70652.1| Hypothetical protein CBG17357
[Caenorhabditis briggsae]
Length = 1268
Score = 737 bits (1902), Expect = 0.0
Identities = 431/1241 (34%), Positives = 693/1241 (55%), Gaps = 55/1241 (4%)
Frame = -1
Query: 3588 VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEK 3409
VF+ S + L G++ S + G PF S F ++ L+ N T++
Sbjct: 34 VFRDSDWRDYALVAGGIILSAVNGALVPFNSLIFEGIANALMEGEAQYQNGTLNMPWFSS 93
Query: 3408 AYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQY 3229
+ + +F G A F+ + +A + + + + +RK Y+ +L++DA++
Sbjct: 94 EIKFF-------CLRYFYLGLALFLCSYCANACLYTLCERRLHCIRKHYLKSVLRQDAKW 146
Query: 3228 FDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFS 3049
FD + G L+ ++ +E+ ++ +KI +I+ V F G +L FY W+L +
Sbjct: 147 FDQHTIGGLTQKMSSGIEKIKDGIGDKIGVIVGGVATFISGVSLGFYMCWQLTLVMLITV 206
Query: 3048 LGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELK 2869
S ++++ + + T + + Y+NAG +A + + +TV + N Q EI RY+++L+
Sbjct: 207 PLQLGSMYLSAKHLNRATKNEMSAYSNAGGMANEVIAGIRTVMAFNAQPFEINRYSQQLE 266
Query: 2868 AGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYSGTLETAVV----------- 2722
K G+R+A++ +I + V + GAT+ +G + + V
Sbjct: 267 EARKMGVRKAMILAICTSFPLMLMFTCMAVAFWYGATLAAAGAVSSGAVFAVFWAVLIGT 326
Query: 2721 --------------------------VRDDNVIEKDETDYDVEVEVNGNISFKNVKFSYP 2620
+ + I+ +D + ++ G +SF ++F+YP
Sbjct: 327 RRIGEAAPHLGAITGARLAIHDIFKVIDHEPEIKCTSSDGKIPDKIQGKLSFDGIEFTYP 386
Query: 2619 TRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMN 2440
TRPD ++LKG+SF+V GE +ALVG SG GKST + LL+ +YN +G I +DG+ +++ N
Sbjct: 387 TRPDLKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQGAGMIKLDGVPIHEYN 446
Query: 2439 IKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKT 2260
I+ LR IG+V QEP++F T+ ENIR G+ ++ +I A R ANA++F+C T
Sbjct: 447 IRWLRSTIGIVQQEPIIFVATVAENIRMGDDLITDDDIEEACRMANAHEFICKLSDKYNT 506
Query: 2259 IVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTT 2080
++G QLSGGQKQR+AIAR +VR P+ILLLDEATSALD ESE++VQ AL+ AS+GRTT
Sbjct: 507 VIGAGAVQLSGGQKQRVAIARAIVRRPQILLLDEATSALDTESERMVQAALDKASKGRTT 566
Query: 2079 IVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKR-GVYNDLVQAQLLE------SHD 1921
+ +AHRLSTI+NASKI+V +G I E G HDELI+K G+Y +V AQ +E + D
Sbjct: 567 LCIAHRLSTIKNASKILVFDQGLIAERGTHDELISKEDGIYASMVAAQEIERAKEDTTLD 626
Query: 1920 DHEE-----------LPPLAARQLSQELSPLHSYAIQRSTSNDAGVHDDDMERILDELSK 1774
D E+ + R+L Q L+ + Q S V + ++E +E+ +
Sbjct: 627 DEEDEKDHRMFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPEWEIESAREEMIE 686
Query: 1773 EGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYY 1594
EGA +++L +I K P+ + IA+ + I+G+++P + + + + + G+D+
Sbjct: 687 EGAMEASLVDIFKFASPEGRNIIIALVFTLIRGLTWPAFSIVYGQLFRILSAGGDDVSIK 746
Query: 1593 SHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSA 1414
+ L +L F+ LA ++ GK E +S RLR+ F +++ +++DDP H+
Sbjct: 747 ALLNSLWFLLLAFTSGISTLVSGGLLGKAGETMSGRLRMDVFRNIMQQDASYFDDPKHNV 806
Query: 1413 TRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXX 1234
L++RL TD+ NV+AA+D RL V+ VV++ ++ A Y W M L
Sbjct: 807 GALTSRLATDAPNVQAAIDQRLAEVLTGVVSLFCGVSVAFFYGWNMAPIGLATALLLVVV 866
Query: 1233 XXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSY 1054
Q D + ++R E++ N +TV++L ++ + + H+
Sbjct: 867 QSAVAQYLKFRGQRDMDSAIEASRLVTESISNWKTVQSLTKQEYMYDSFVAASKSPHRRA 926
Query: 1053 FKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSA 874
R + Q + L+ S ++ +++++ FG +L P + V+ L+M + A
Sbjct: 927 IVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNGWSTPYTVFQVIEALNMASMSVMLA 986
Query: 873 AAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMI 694
A+Y P+Y +A +AG++F + + + G KG+I V F Y R +++
Sbjct: 987 ASYFPEYVRARISAGIMFTMIRQRSVIDNRGLTGDTPPIKGDISMREVYFAYPNRRRQLV 1046
Query: 693 LNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSN 514
L+ N+ G+T+ALVGPSGCGKST I L+ER+Y A+ G++K+D ++ +I++ HLR N
Sbjct: 1047 LDSFNMTAKFGQTVALVGPSGCGKSTTIQLIERYYDALSGKIKVDGCDIREISVKHLRDN 1106
Query: 513 LALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERG 334
+ALV QEPTLFN +IREN+ YGL + + Q E+EKA AN FV P+G DT VG G
Sbjct: 1107 IALVGQEPTLFNLTIRENITYGLEK-ISQEEVEKAATLANIHTFVMGLPEGYDTSVGASG 1165
Query: 333 AQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHR 154
+LSGGQKQR+AIARAI+R+PK+LLLDEATSALD++SEK+VQ ALD A + +V+AHR
Sbjct: 1166 GRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCIVIAHR 1225
Query: 153 LSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
LST+ NAD I V +NGK E+GTH+ LL +R +Y+RLV+KQ
Sbjct: 1226 LSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 1266
>gi|1170902|sp|P43245|MDR1_RAT Multidrug resistance protein 1
(P-glycoprotein 1)
gi|92489|pir||JH0502 p-glycoprotein - rat
Length = 1277
Score = 734 bits (1894), Expect = 0.0
Identities = 450/1254 (35%), Positives = 697/1254 (54%), Gaps = 57/1254 (4%)
Frame = -1
Query: 3627 EKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNA 3448
EKKP+ I +F+ + +K LG L +++ G P + FG ++ +
Sbjct: 27 EKKPAV---GIFGMFRYADWLDKLCMALGTLAAIIHGTLLPLLMLVFGYMTDSFTPSRDP 83
Query: 3447 INNKTI-DPADLEKAYE----EYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTT 3283
+++ I + +++ + E M +++ G I A +Q ++
Sbjct: 84 HSDRAITNQSEINSTHTVSDTSLEEDMAMYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQI 143
Query: 3282 YRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGT 3103
+++R+++ ++ ++ +FD G L+T L D++ + + +K+ + +T F+ G
Sbjct: 144 HKIRQKFFHAIMNQEIGWFDVNDAGELNTRLTDDVSKINDGIGDKLGMFFQSITTFSAGF 203
Query: 3102 ALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTV 2923
+ F + W+L + S I S + + + T K+ YA AG++A + L A +TV
Sbjct: 204 IIGFISGWKLTLVILAVSPLIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRTV 263
Query: 2922 CSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYS- 2746
+ GQK E+ERY + L+ ++ GI++A+ +IS G+ Y + + + G +++ S
Sbjct: 264 IAFGGQKKELERYNKNLEEAKRVGIKKAITANISIGIAYLLVYASYALAFWYGTSLVLSN 323
Query: 2745 ----------------GTL--------------------ETAVVVRDDNVIEKDETDYDV 2674
GT E ++ ++ I+ T
Sbjct: 324 EYSIGQVLTVFFSILLGTFSIGHLAPNIEAFANARGAAYEIFKIIDNEPSIDSFSTKGHK 383
Query: 2673 EVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYY 2494
+ GN+ FKNV F+YP+R + ++LKG++ V++G+ +ALVG SG GKST VQLL Y
Sbjct: 384 PDSIMGNLEFKNVYFNYPSRSEVKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLY 443
Query: 2493 NIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGAL 2314
+ G + IDG D+ +N++ LR +IGVVSQEPVLF TTI ENIR+G NV++ EI A+
Sbjct: 444 DPIEGEVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAV 503
Query: 2313 RKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNE 2134
++ANAYDF+ P T+VGERG QLSGGQKQRIAIAR LVRNPKILLLDEATSALD E
Sbjct: 504 KEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTE 563
Query: 2133 SEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYND 1954
SE VVQ AL+ A +GRTTIV+AHRLST+RNA I G IVE GNH+EL+ ++G+Y
Sbjct: 564 SEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEELMKEKGIYFK 623
Query: 1953 LVQAQ-----LLESHDDHEELPPLAARQLSQE--LSPLHSYAIQRSTSNDAGVHDDDMER 1795
LV Q + ++ +E A +L+ E SPL +I+RS D ER
Sbjct: 624 LVMTQTRGNEIEPGNNAYESQSDTGASELTSEESKSPLIRRSIRRSIH-----RRQDQER 678
Query: 1794 ILD--ELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFA 1621
L E E + +I+K ++ +L + V + I G P+ A + + F+
Sbjct: 679 RLSSKEDVDEDVPMVSFWQILKLNISEWPYLVVGVLCAVINGCIQPVFAIVFSKIVGVFS 738
Query: 1620 MIG--EDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLP 1447
E +L++L F+ + + +T + Q + FGK E L+ RLR F ML
Sbjct: 739 RDDDHETKQRNCNLFSLLFLVMGMISFVTYFFQGFTFGKAGEILTKRLRYMVFKSMLRQD 798
Query: 1446 CAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTV--VAISIAITTASLYCWKMT 1273
+++DD ++ L+ RL +D+SNVK A+ RL V V + I ++ +Y W++T
Sbjct: 799 ISWFDDHKNTTGSLTTRLASDASNVKGAMGSRLAVVTQNVANLGTGIILSLVLVYGWQLT 858
Query: 1272 LEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMS 1093
L +++ P +D E S + A EA+EN RTV +L E K +
Sbjct: 859 LLLVVIIPLIVLGGIIEMKLLSGQALKDKKELEISGKIATEAIENFRTVVSLTREQKFET 918
Query: 1092 LISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVL 913
+ ++ LQ +++ K+A + G + + F Y+ F+FG YL R+ + + LV
Sbjct: 919 MYAQSLQIPYRNALKKAHVFGITFAFTQAMIYFSYAACFRFGAYLVARELMTFENVMLVF 978
Query: 912 MTLSMTANMAGSAAAYLPDYKKA-VHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGE 736
+ A AG+ +++ PDY KA V A+ +I + P +S+ K N +G +
Sbjct: 979 SAVVFGAMAAGNTSSFAPDYAKAKVSASHIIGIIEKIPEIDSYSTEGLKPNWLEGNVKFN 1038
Query: 735 NVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDS 556
V+F+Y RP+ +L G++ +V G+TL LVG SGCGKST++ LLERFY+ + G V +D
Sbjct: 1039 GVKFNYPTRPNIPVLQGLSFEVKKGQTLRLVGSSGCGKSTVVQLLERFYNPMAGTVFLDG 1098
Query: 555 ENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYG-LTRSVPQLELEKALQTANAFNFV 379
+ ++ +N+ +R+ L +VSQEP LF+CSI EN+ YG +R V E+ +A + AN F+
Sbjct: 1099 KEIKQLNVQCVRA-LGIVSQEPILFDCSIAENIAYGDNSRVVSHEEIVRAAREANIHQFI 1157
Query: 378 FQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNAL 199
P+ +T VG++G QLSGGQKQRIAIARA++R P +LLLDEATSALD++SEKVVQ AL
Sbjct: 1158 DSLPEKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEAL 1217
Query: 198 DTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQ 37
D A E + VV+AHRLST+ NAD I V++NG+V E GTH++LL ++ IY+ +VQ
Sbjct: 1218 DKAREGRTCVVIAHRLSTIQNADLIVVIQNGQVKEHGTHQQLLAQKGIYFSMVQ 1271
Score = 328 bits (842), Expect = 4e-88
Identities = 192/494 (38%), Positives = 286/494 (57%), Gaps = 3/494 (0%)
Frame = -1
Query: 1488 RLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIA 1309
++R K F +++ ++D + A L+ RL D S + + D+LG ++ S
Sbjct: 145 KIRQKFFHAIMNQEIGWFDV--NDAGELNTRLTDDVSKINDGIGDKLGMFFQSITTFSAG 202
Query: 1308 ITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRT 1129
+ WK+TL +L P ++ A+ + A E L +RT
Sbjct: 203 FIIGFISGWKLTLVILAVSPLIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRT 262
Query: 1128 VRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALR 949
V A + K + +++L++ + K+AI + G++ Y+++F +GT L L
Sbjct: 263 VIAFGGQKKELERYNKNLEEAKRVGIKKAITANISIGIAYLLVYASYALAFWYGTSLVLS 322
Query: 948 KEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLF-TYPATMPFSSSDG 772
E + V ++ + G A + + A AA IF + P+ FS+
Sbjct: 323 NEYSIGQVLTVFFSILLGTFSIGHLAPNIEAFANARGAAYEIFKIIDNEPSIDSFSTKGH 382
Query: 771 KKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERF 592
K + G + +NV F+Y R + IL G+NLKV G+T+ALVG SGCGKST + LL+R
Sbjct: 383 KPDSIMGNLEFKNVYFNYPSRSEVKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRL 442
Query: 591 YHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEK 412
Y ++GEV ID +++ IN+ +LR + +VSQEP LF +I EN+ YG +V E+EK
Sbjct: 443 YDPIEGEVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYG-RENVTMDEIEK 501
Query: 411 ALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALD 232
A++ ANA++F+ + P DTLVGERGAQLSGGQKQRIAIARA++RNPK+LLLDEATSALD
Sbjct: 502 AVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALD 561
Query: 231 SDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIY 52
++SE VVQ ALD A E +T+V+AHRLSTV NAD IA G + EQG HEEL++++ IY
Sbjct: 562 TESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEELMKEKGIY 621
Query: 51 WRLV--QKQGIQVE 16
++LV Q +G ++E
Sbjct: 622 FKLVMTQTRGNEIE 635
Score = 300 bits (768), Expect = 2e-79
Identities = 191/579 (32%), Positives = 301/579 (50%), Gaps = 43/579 (7%)
Frame = -1
Query: 3549 LLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQVV 3370
++GVL +++ G QP + F ++ V + +E +R N
Sbjct: 710 VVGVLCAVINGCIQPVFAIVFSKIVGVF---------------SRDDDHETKQRNCNLFS 754
Query: 3369 FHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSV--STGHLST 3196
F + G F+ Q G+ T R+R +L++D +FD +TG L+T
Sbjct: 755 LLFLVMGMISFVTYFFQGFTFGKAGEILTKRLRYMVFKSMLRQDISWFDDHKNTTGSLTT 814
Query: 3195 VLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYT--DWRLASYGIFFSLGIAFSGFI 3022
L + + ++A++ V + G L+ W+L + I G I
Sbjct: 815 RLASDASNVKGAMGSRLAVVTQNVANLGTGIILSLVLVYGWQLTLLLVVIIPLIVLGGII 874
Query: 3021 NSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRR 2842
+ K +G IA + + ++TV SL ++ Y + L+ + +++
Sbjct: 875 EMKLLSGQALKDKKELEISGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNALKK 934
Query: 2841 ALMYSISRGVT-------YFFCNSLNTVVL------YVGATMIYSGTLETAVVVRDDNVI 2701
A ++ I+ T Y C ++ + +++S + A+ + +
Sbjct: 935 AHVFGITFAFTQAMIYFSYAACFRFGAYLVARELMTFENVMLVFSAVVFGAMAAGNTSSF 994
Query: 2700 EKDETDYDVEVE------------------------VNGNISFKNVKFSYPTRPDAQVLK 2593
D V + GN+ F VKF+YPTRP+ VL+
Sbjct: 995 APDYAKAKVSASHIIGIIEKIPEIDSYSTEGLKPNWLEGNVKFNGVKFNYPTRPNIPVLQ 1054
Query: 2592 GISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIG 2413
G+SF+V+ G+ + LVG+SG GKSTVVQLL +YN +G +F+DG ++ +N++ +R +G
Sbjct: 1055 GLSFEVKKGQTLRLVGSSGCGKSTVVQLLERFYNPMAGTVFLDGKEIKQLNVQCVR-ALG 1113
Query: 2412 VVSQEPVLFNTTIEENIRFGNPN--VSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGT 2239
+VSQEP+LF+ +I ENI +G+ + VS EI A R+AN + F+ S P+ T VG++GT
Sbjct: 1114 IVSQEPILFDCSIAENIAYGDNSRVVSHEEIVRAAREANIHQFIDSLPEKYNTRVGDKGT 1173
Query: 2238 QLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRL 2059
QLSGGQKQRIAIAR LVR P ILLLDEATSALD ESE+VVQ+AL+ A +GRT +V+AHRL
Sbjct: 1174 QLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCVVIAHRL 1233
Query: 2058 STIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQA 1942
STI+NA I+V+Q G++ E G H +L+A++G+Y +VQA
Sbjct: 1234 STIQNADLIVVIQNGQVKEHGTHQQLLAQKGIYFSMVQA 1272
>gi|17569143|ref|NP_509901.1| P-GlycoProtein related (pgp-3)
[Caenorhabditis elegans]
gi|29429184|sp|P34713|MDR3_CAEEL Multidrug resistance protein 3
(P-glycoprotein C)
gi|7511155|pir||T22094 hypothetical protein ZK455.7 - Caenorhabditis
elegans
gi|3877009|emb|CAA91467.1| Hypothetical protein ZK455.7
[Caenorhabditis elegans]
gi|3881645|emb|CAA91495.1| C. elegans PGP-3 protein (corresponding
sequence ZK455.7) [Caenorhabditis elegans]
Length = 1268
Score = 733 bits (1893), Expect = 0.0
Identities = 426/1241 (34%), Positives = 691/1241 (55%), Gaps = 55/1241 (4%)
Frame = -1
Query: 3588 VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEK 3409
VF+ + + LF G++ S + G PF S F ++ L+ + N TI+
Sbjct: 34 VFRDADYKDYILFSGGLILSAVNGALVPFNSLIFEGIANALMEGESQYQNGTIN------ 87
Query: 3408 AYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQY 3229
+ + +F G A F+ + ++ + + + + +RK+Y+ +L++DA++
Sbjct: 88 -MPWFSSEIKMFCLRYFYLGVALFLCSYFANSCLYTLCERRLHCIRKKYLKSVLRQDAKW 146
Query: 3228 FDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFS 3049
FD + G L+ ++ +E+ ++ +K+ +++ V F G ++ FY W+L +
Sbjct: 147 FDETTIGGLTQKMSSGIEKIKDGIGDKVGVLVGGVATFISGVSIGFYMCWQLTLVMMITV 206
Query: 3048 LGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELK 2869
S ++++ + + T + + Y+NAG +A + + +TV + N Q EI RY +L
Sbjct: 207 PLQLGSMYLSAKHLNRATKNEMSAYSNAGGMANEVIAGIRTVMAFNAQPFEINRYAHQLN 266
Query: 2868 AGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYSGTLETAVV----------- 2722
+ GIR+A++ +I + V + GAT+ +G + + V
Sbjct: 267 EARRMGIRKAIILAICTAFPLMLMFTCMAVAFWYGATLAAAGAVSSGAVFAVFWAVLIGT 326
Query: 2721 --------------------------VRDDNVIEKDETDYDVEVEVNGNISFKNVKFSYP 2620
+ + I+ ++ + ++ G ++F ++F+YP
Sbjct: 327 RRLGEAAPHLGAITGARLAIHDIFKVIDHEPEIKCTSSEGKIPEKIQGKLTFDGIEFTYP 386
Query: 2619 TRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMN 2440
TRP+ ++LKG+SF+V GE +ALVG SG GKST + LL+ +YN +G I +DG+ + + N
Sbjct: 387 TRPELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYN 446
Query: 2439 IKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKT 2260
I+ LR IG+V QEP++F T+ ENIR G+ ++ +I A + ANA++F+C T
Sbjct: 447 IRWLRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDT 506
Query: 2259 IVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTT 2080
++G QLSGGQKQR+AIAR +VR P+ILLLDEATSALD ESE++VQ AL+ AS+GRTT
Sbjct: 507 VIGAGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTT 566
Query: 2079 IVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAK-RGVYNDLVQAQLLE------SHD 1921
+ +AHRLSTIRNASKI+V +G I E G HDELI+K G+Y +V+AQ +E + D
Sbjct: 567 LCIAHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAKEDTTLD 626
Query: 1920 DHEE-----------LPPLAARQLSQELSPLHSYAIQRSTSNDAGVHDDDMERILDELSK 1774
D E+ + R+L Q L+ + Q S V + ++E +E+ +
Sbjct: 627 DEEDEKTHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPEWEIENAREEMIE 686
Query: 1773 EGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYY 1594
EGA +++L +I K P+ + I++ + I+G ++P + + + ++ + G+D+
Sbjct: 687 EGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIK 746
Query: 1593 SHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSA 1414
+ L +L F+ LA ++ GK E +S RLR+ F +++ +++DD H+
Sbjct: 747 ALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNV 806
Query: 1413 TRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXX 1234
L++RL TD+ NV+AA+D RL V+ +V++ + A Y W M L
Sbjct: 807 GSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGLATALLLVVV 866
Query: 1233 XXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSY 1054
Q D + ++R E++ N +TV+AL ++ + + + H+
Sbjct: 867 QSSVAQYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRA 926
Query: 1053 FKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSA 874
R + Q + L+ S ++ +++++ FG +L P + V+ L+M + A
Sbjct: 927 IVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLA 986
Query: 873 AAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMI 694
A+Y P+Y +A +AG++F + + + G KG I V F Y R +++
Sbjct: 987 ASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFAYPNRRRQLV 1046
Query: 693 LNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSN 514
L+G N+ + G+T+ALVGPSGCGKST I L+ER+Y A+ G VKID ++ D+++ HLR N
Sbjct: 1047 LDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDN 1106
Query: 513 LALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERG 334
+ALV QEPTLFN +IREN+ YGL ++ Q ++EKA AN FV P G DT VG G
Sbjct: 1107 IALVGQEPTLFNLTIRENITYGL-ENITQDQVEKAATLANIHTFVMGLPDGYDTSVGASG 1165
Query: 333 AQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHR 154
+LSGGQKQR+AIARAI+R+PK+LLLDEATSALD++SEK+VQ ALD A + VV+AHR
Sbjct: 1166 GRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHR 1225
Query: 153 LSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
LST+ NAD I V +NGK E+GTH+ LL +R +Y+RLV+KQ
Sbjct: 1226 LSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 1266
Score = 282 bits (722), Expect = 4e-74
Identities = 186/583 (31%), Positives = 302/583 (50%), Gaps = 16/583 (2%)
Frame = -1
Query: 1722 DYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFA---MIGE--------DMLYYSH---L 1585
DY + SA+ G P + + +EG A M GE +M ++S +
Sbjct: 42 DYILFSGGLILSAVNGALVPFNSLI----FEGIANALMEGESQYQNGTINMPWFSSEIKM 97
Query: 1584 WALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRL 1405
+ L + +L V L Y + E+ +R K +L ++D+ L
Sbjct: 98 FCLRYFYLGVALFLCSYFANSCLYTLCERRLHCIRKKYLKSVLRQDAKWFDETTIGG--L 155
Query: 1404 SNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXX 1225
+ ++++ +K + D++G ++ V ++ CW++TL +++ P
Sbjct: 156 TQKMSSGIEKIKDGIGDKVGVLVGGVATFISGVSIGFYMCWQLTLVMMITVPLQLGSMYL 215
Query: 1224 XXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKR 1045
A + + A+ N+ A E + +RTV A N + ++ + L + + ++
Sbjct: 216 SAKHLNRATKNEMSAYSNAGGMANEVIAGIRTVMAFNAQPFEINRYAHQLNEARRMGIRK 275
Query: 1044 AIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAY 865
AII L +V+F +G LA V+ + V + + G AA +
Sbjct: 276 AIILAICTAFPLMLMFTCMAVAFWYGATLAAAGAVSSGAVFAVFWAVLIGTRRLGEAAPH 335
Query: 864 LPDYKKAVHAAGLIFHLFTYPATMPFSSSDGK-KNIEKGEIIGENVQFHYDQRPDRMILN 688
L A A IF + + + +SS+GK +G++ + ++F Y RP+ IL
Sbjct: 336 LGAITGARLAIHDIFKVIDHEPEIKCTSSEGKIPEKIQGKLTFDGIEFTYPTRPELKILK 395
Query: 687 GVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLA 508
GV+ +V+PG+T+ALVG SGCGKST I LL RFY+ G +K+D +++ N+ LRS +
Sbjct: 396 GVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRWLRSTIG 455
Query: 507 LVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQ 328
+V QEP +F ++ EN+ G Q ++E+A + ANA F+ + DT++G Q
Sbjct: 456 IVQQEPIIFVATVAENIRMGDVLITDQ-DIEEACKMANAHEFICKLSDRYDTVIGAGAVQ 514
Query: 327 LSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLS 148
LSGGQKQR+AIARAI+R P++LLLDEATSALD++SE++VQ ALD ASE +T+ +AHRLS
Sbjct: 515 LSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCIAHRLS 574
Query: 147 TVVNADSIAVLKNGKVAEQGTHEELLRK-RSIYWRLVQKQGIQ 22
T+ NA I V G +AE+GTH+EL+ K IY +V+ Q I+
Sbjct: 575 TIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIE 617
>gi|126930|sp|P23174|MDR3_CRIGR Multidrug resistance protein 3
(P-glycoprotein 3)
gi|2119778|pir||I48123 p-glycoprotein isoform III - Chinese hamster
gi|191169|gb|AAA68885.1| p-glycoprotein isoform III
Length = 1281
Score = 733 bits (1892), Expect = 0.0
Identities = 446/1233 (36%), Positives = 675/1233 (54%), Gaps = 47/1233 (3%)
Frame = -1
Query: 3588 VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEK 3409
+F+ S +K LLG + ++ G P M FGE++ V + +
Sbjct: 45 LFRYSDWQDKLFMLLGTIMAIAHGSGLPLMMIVFGEMTDKFVNNAGNFSLPVNFSLSMIN 104
Query: 3408 AYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQY 3229
E M + +++ G + A +Q + ++R+ + +L+++ +
Sbjct: 105 PGRILEEEMTRYAYYYSGLGGGVLVAAYIQVSFWTLAAGRQIKKIRQNFFHAILRQEMGW 164
Query: 3228 FDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFS 3049
FD T L+T L D++ + E +K+ + V F G + F W+L + S
Sbjct: 165 FDIKGTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAIS 224
Query: 3048 LGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELK 2869
+ S + + + + K+ YA AG++A + LGA +TV + GQ E+ERY + L+
Sbjct: 225 PILGLSAAVWAKILSTFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLE 284
Query: 2868 AGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYSG--TLETAVVV-------- 2719
+K GI++A+ +IS G+ + + + + G+T++ S T+ A+ V
Sbjct: 285 NAKKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGA 344
Query: 2718 ----------------RDDNVIEKDETDYDVEVE-----------VNGNISFKNVKFSYP 2620
R + D D + +++ + GN+ F +V FSYP
Sbjct: 345 FSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLDFSDVHFSYP 404
Query: 2619 TRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMN 2440
+R + ++LKG++ VQ+G+ +ALVG SG GK+T +QLL Y+ G I IDG D+ + N
Sbjct: 405 SRANIKILKGLNLKVQSGQTVALVGNSGCGKTTTLQLLQRLYDPTEGTISIDGQDIRNFN 464
Query: 2439 IKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKT 2260
++ LR +IGVVSQEPVLF+TTI ENIR+G NV++ EI A+++ANAY+F+ P+ T
Sbjct: 465 VRYLREIIGVVSQEPVLFSTTIAENIRYGRGNVTMEEIKKAVKEANAYEFIMKLPQKFDT 524
Query: 2259 IVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTT 2080
+VGERG QLSGGQKQRIAIAR LVRNPKILLLDEATSALD ESE VQ AL+ A +GRTT
Sbjct: 525 LVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTT 584
Query: 2079 IVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLESHDDHEELP- 1903
IV+AHRLST+RNA I + G IVE G+H EL+ K GVY LV Q S +E
Sbjct: 585 IVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMQKEGVYFKLVNMQTSGSQILSQEFEV 644
Query: 1902 PLAARQLSQELSP--LHSYAIQRSTS---NDAGVHDDDMERILDELSKEGAKKSNLREIV 1738
L+ + + ++P S+ + ST + H ++ DEL S L+ ++
Sbjct: 645 ELSEEKAADGMTPNGWKSHIFRNSTKKSLKSSRAHHHRLDVDADELDANVPPVSFLK-VL 703
Query: 1737 KQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYYS--HLWALSFMF 1564
K + ++ + + + + G P ++ ++ F G+D + +L++L F+
Sbjct: 704 KLNKTEWPYFVVGTVCAIVNGALQPAISIILSEMIAIFGP-GDDAVKQQKCNLFSLVFLG 762
Query: 1563 LAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTD 1384
L V T + Q + FGK E L+TRLR +F ML +++DD +S LS RL TD
Sbjct: 763 LGVLSFFTFFLQGFTFGKAGEILTTRLRSMAFKAMLRQDMSWFDDYKNSTGALSTRLATD 822
Query: 1383 SSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXX 1204
+ V+ A RL + + I + +Y W++TL +L P
Sbjct: 823 RAQVQGATGTRLALIAQNTANLGTGIIISFIYGWQLTLLLLSVVPFIAVSGIVEMKMLAG 882
Query: 1203 AIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAA 1024
+ D A E + + A EA+EN+RTV +L E K S+ E L + +++ + A I G
Sbjct: 883 NAKRDKKALEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLHEPYRNSVQMAHIYGIT 942
Query: 1023 NGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKA 844
+S + F Y+ F+FG YL + + D LV + A G A+++ PDY KA
Sbjct: 943 FSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKA 1002
Query: 843 VHAAGLIFHLFTYPATMPFSSSDGK-KNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVD 667
+A +F LF + S +G + +G + V F+Y R + +L G++L+V
Sbjct: 1003 KLSAAHLFSLFERQPLIDSYSGEGLWPDKFEGSVTFNEVVFNYPTRANMPVLQGLSLEVK 1062
Query: 666 PGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPT 487
G+TLALVG SGCGKST++ LLERFY + G V +D + + +N+ LR+ L +VSQEP
Sbjct: 1063 KGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVLLDGQEAKKLNIQWLRAQLGIVSQEPV 1122
Query: 486 LFNCSIRENLLYG-LTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQK 310
LF+CSI EN+ YG +R V Q E+ +A + AN F+ PQ T VG++G QLSGGQK
Sbjct: 1123 LFDCSIAENIAYGDNSRVVSQDEIVRAAKAANIHPFIETLPQKYKTRVGDKGTQLSGGQK 1182
Query: 309 QRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNAD 130
QR+AI RA++R P+VLLLDEATSALD++SEKVVQ ALD A E + +V+AHRLST+ NAD
Sbjct: 1183 QRLAIRRALIRQPRVLLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNAD 1242
Query: 129 SIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
I V++NGKV E GTH++LL ++ IY+ +V Q
Sbjct: 1243 LIVVIQNGKVKEHGTHQQLLAQKGIYFSMVNIQ 1275
>gi|6679297|ref|NP_032856.1| ATP-binding cassette, sub-family B
(MDR/TAP), member 4; P glycoprotein 2 [Mus musculus]
gi|126929|sp|P21440|MDR2_MOUSE Multidrug resistance protein 2
(P-glycoprotein 2)
gi|72476|pir||DVMS2 multidrug resistance protein 2 - mouse
gi|387428|gb|AAA39516.1| multidrug resistance protein
Length = 1276
Score = 732 bits (1890), Expect = 0.0
Identities = 450/1249 (36%), Positives = 685/1249 (54%), Gaps = 47/1249 (3%)
Frame = -1
Query: 3636 QSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTI 3457
Q EKK + +F+ S +K LG L ++ G P M FGE++ V
Sbjct: 26 QGREKKKKVNLIGLLTLFRYSDWQDKLFMFLGTLMAIAHGSGLPLMMIVFGEMTDKFVDN 85
Query: 3456 TNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYR 3277
T + + E M + +++ G + A +Q + +
Sbjct: 86 TGNFSLPVNFSLSMLNPGRILEEEMTRYAYYYSGLGGGVLVAAYIQVSFWTLAAGRQIKK 145
Query: 3276 VRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTAL 3097
+R+++ +L+++ +FD T L+T L D++ + E +K+ + + F G +
Sbjct: 146 IRQKFFHAILRQEMGWFDIKGTTELNTRLTDDVSKISEGIGDKVGMFFQAIATFFAGFIV 205
Query: 3096 AFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCS 2917
F W+L + S + S + + + + K+ YA AG++A + GA +TV +
Sbjct: 206 GFIRGWKLTLVIMAISPILGLSTAVWAKILSTFSDKELAAYAKAGAVAEEAPGAIRTVIA 265
Query: 2916 LNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYSG-- 2743
GQ E+ERY + L+ +K GI++A+ +IS G+ + + + + G+T++ S
Sbjct: 266 FGGQNKELERYQKHLENAKKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEY 325
Query: 2742 TLETAVVV------------------------RDDNVIEKDETDYDVEVE---------- 2665
T+ A+ V R + D D + +++
Sbjct: 326 TIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPD 385
Query: 2664 -VNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNI 2488
+ GN+ F +V FSYP+R + ++LKG++ V++G+ +ALVG SG GKST VQLL Y+
Sbjct: 386 NIKGNLEFSDVHFSYPSRANIKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDP 445
Query: 2487 DSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRK 2308
G I IDG D+ + N++ LR +IGVVSQEPVLF+TTI ENIR+G NV++ EI A+++
Sbjct: 446 TEGKISIDGQDIRNFNVRCLREIIGVVSQEPVLFSTTIAENIRYGRGNVTMDEIEKAVKE 505
Query: 2307 ANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESE 2128
ANAYDF+ P+ T+VG+RG QLSGGQKQRIAIAR LVRNPKILLLDEATSALD ESE
Sbjct: 506 ANAYDFIMKLPQKFDTLVGDRGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESE 565
Query: 2127 QVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLV 1948
VQ AL+ A +GRTTIV+AHRLSTIRNA I + G IVE G+H EL+ K G+Y LV
Sbjct: 566 AEVQAALDKAREGRTTIVIAHRLSTIRNADVIAGFEDGVIVEQGSHSELMKKEGIYFRLV 625
Query: 1947 QAQLLESHDDHEELP-PLAARQLSQELSP--LHSYAIQRSTSND-AGVHDDDMERILDEL 1780
Q S EE L+ + + +++P + + ST H + ++ +EL
Sbjct: 626 NMQTAGSQILSEEFEVELSDEKAAGDVAPNGWKARIFRNSTKKSLKSPHQNRLDEETNEL 685
Query: 1779 SKEGAKKSNLREIVKQCRPDYCFLFI----AVFGSAIQGVSYPILAQLIVRTYEGFAMIG 1612
S L+ ++K + ++ + + A+ A+Q IL+++I G +
Sbjct: 686 DANVPPVSFLK-VLKLNKTEWPYFVVGTVCAIANGALQPAFSIILSEMIAIFGPGDDAVK 744
Query: 1611 EDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYD 1432
+ ++++L F+ L V T + Q + FGK E L+TRLR +F ML +++D
Sbjct: 745 QQK---CNMFSLVFLGLGVLSFFTFFLQGFTFGKAGEILTTRLRSMAFKAMLRQDMSWFD 801
Query: 1431 DPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFF 1252
D +S LS RL TD++ V+ A +L + + I + +Y W++TL +L
Sbjct: 802 DHKNSTGALSTRLATDAAQVQGATGTKLALIAQNTANLGTGIIISFIYGWQLTLLLLSVV 861
Query: 1251 PXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQ 1072
P + D E + + A EA+EN+RTV +L E K S+ E L
Sbjct: 862 PFIAVAGIVEMKMLAGNAKRDKKEMEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLH 921
Query: 1071 KIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTA 892
+++ ++A I G +S + F Y+ F+FG+YL + + D LV + + A
Sbjct: 922 GPYRNSVRKAHIYGITFSISQAFMYFSYAGCFRFGSYLIVNGHMRFKDVILVFSAIVLGA 981
Query: 891 NMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGK-KNIEKGEIIGENVQFHYD 715
G A+++ PDY KA +A +F LF + S +G + +G + V F+Y
Sbjct: 982 VALGHASSFAPDYAKAKLSAAYLFSLFERQPLIDSYSGEGLWPDKFEGSVTFNEVVFNYP 1041
Query: 714 QRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDIN 535
R + +L G++L+V G+TLALVG SGCGKST++ LLERFY + G V +D + + +N
Sbjct: 1042 TRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVLLDGQEAKKLN 1101
Query: 534 LNHLRSNLALVSQEPTLFNCSIRENLLYG-LTRSVPQLELEKALQTANAFNFVFQFPQGL 358
+ LR+ L +VSQEP LF+CSI EN+ YG +R VP E+ +A + AN F+ PQ
Sbjct: 1102 VQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVPHDEIVRAAKEANIHPFIETLPQKY 1161
Query: 357 DTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERL 178
+T VG++G QLSGGQKQRIAIARA++R P+VLLLDEATSALD++SEKVVQ ALD A E
Sbjct: 1162 NTRVGDKGTQLSGGQKQRIAIARALIRQPRVLLLDEATSALDTESEKVVQEALDKAREGR 1221
Query: 177 STVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
+ +V+AHRLST+ NAD I V++NGKV E GTH++LL ++ IY+ +V Q
Sbjct: 1222 TCIVIAHRLSTIQNADLIVVIENGKVKEHGTHQQLLAQKGIYFSMVNIQ 1270
>gi|4505771|ref|NP_000434.1| ATP-binding cassette, subfamily B, member
4 isoform A; P glycoprotein 3/multiple drug resistance 3;
P-glycoprotein-3/multiple drug resistance-3; multiple
drug resistance 3 [Homo sapiens]
gi|126932|sp|P21439|MDR3_HUMAN Multidrug resistance protein 3
(P-glycoprotein 3)
gi|72473|pir||DVHU3 multidrug resistance protein 3 - human
gi|307181|gb|AAA36207.1| P-glycoprotein
Length = 1279
Score = 728 bits (1878), Expect = 0.0
Identities = 443/1242 (35%), Positives = 674/1242 (53%), Gaps = 53/1242 (4%)
Frame = -1
Query: 3597 IRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPAD 3418
+ +F+ S +K LG + ++ G P M FGE++ V +
Sbjct: 42 VLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLS 101
Query: 3417 LEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKD 3238
L + E M + +++ G + A +Q + ++R+++ +L+++
Sbjct: 102 LLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQE 161
Query: 3237 AQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGI 3058
+FD T L+T L D++ + E +K+ + V F G + F W+L +
Sbjct: 162 IGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIM 221
Query: 3057 FFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTE 2878
S + S + + + + K+ YA AG++A + LGA +TV + GQ E+ERY +
Sbjct: 222 AISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQK 281
Query: 2877 ELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYSG--TLETAVVV----- 2719
L+ ++ GI++A+ +IS G+ + + + + G+T++ S T+ A+ V
Sbjct: 282 HLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSIL 341
Query: 2718 -------------------RDDNVIEKDETDYDVEVE-----------VNGNISFKNVKF 2629
R + D D + +++ + GN+ F +V F
Sbjct: 342 IGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHF 401
Query: 2628 SYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLN 2449
SYP+R + ++LKG++ VQ+G+ +ALVG+SG GKST VQL+ Y+ D G I IDG D+
Sbjct: 402 SYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIR 461
Query: 2448 DMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKG 2269
+ N+ LR +IGVVSQEPVLF+TTI ENI +G NV++ EI A+++ANAY+F+ P+
Sbjct: 462 NFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQK 521
Query: 2268 IKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQG 2089
T+VGERG QLSGGQKQRIAIAR LVRNPKILLLDEATSALD ESE VQ AL+ A +G
Sbjct: 522 FDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREG 581
Query: 2088 RTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLESHDDHEE 1909
RTTIV+AHRLST+RNA I + G IVE G+H EL+ K GVY LV Q S EE
Sbjct: 582 RTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEE 641
Query: 1908 LPPLAARQLSQELSP------LHSYAIQRSTSN------DAGVHDDDMERILDELSKEGA 1765
L + + ++P L ++ Q++ N V D +E + +S
Sbjct: 642 F-ELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVS---- 696
Query: 1764 KKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYYS-- 1591
+++K + ++ + + + G P + + F G+D +
Sbjct: 697 ----FLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGP-GDDAVKQQKC 751
Query: 1590 HLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSAT 1411
++++L F+FL + T + Q + FGK E L+ RLR +F ML +++DD +S
Sbjct: 752 NIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTG 811
Query: 1410 RLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXX 1231
LS RL TD++ V+ A RL + + + I + +Y W++TL +L P
Sbjct: 812 ALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSG 871
Query: 1230 XXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYF 1051
+ D E + + A EA+EN+RTV +L E K S+ E L +++
Sbjct: 872 IVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSV 931
Query: 1050 KRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAA 871
++A I G +S + F Y+ F+FG YL + + D LV + A G A+
Sbjct: 932 QKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHAS 991
Query: 870 AYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDG-KKNIEKGEIIGENVQFHYDQRPDRMI 694
++ PDY KA +A +F LF + S +G K + +G I V F+Y R + +
Sbjct: 992 SFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPV 1051
Query: 693 LNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSN 514
L G++L+V G+TLALVG SGCGKST++ LLERFY + G V +D + + +N+ LR+
Sbjct: 1052 LQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQ 1111
Query: 513 LALVSQEPTLFNCSIRENLLYG-LTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGER 337
L +VSQEP LF+CSI EN+ YG +R V Q E+ A + AN F+ P +T VG++
Sbjct: 1112 LGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDK 1171
Query: 336 GAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAH 157
G QLSGGQKQRIAIARA++R P++LLLDEATSALD++SEKVVQ ALD A E + +V+AH
Sbjct: 1172 GTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAH 1231
Query: 156 RLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
RLST+ NAD I V +NG+V E GTH++LL ++ IY+ +V Q
Sbjct: 1232 RLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ 1273
Score = 330 bits (847), Expect = 1e-88
Identities = 191/511 (37%), Positives = 290/511 (56%), Gaps = 3/511 (0%)
Frame = -1
Query: 1536 YCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVD 1357
Y Q ++ + + ++R K F +L ++D + T L+ RL D S + +
Sbjct: 132 YIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDI--NDTTELNTRLTDDISKISEGIG 189
Query: 1356 DRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAF 1177
D++G V + WK+TL ++ P ++ A+
Sbjct: 190 DKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAY 249
Query: 1176 ENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFL 997
+ A EAL +RTV A ++K + +HL+ + K+AI + G++
Sbjct: 250 AKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIY 309
Query: 996 FVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFH 817
Y+++F +G+ L + KE + V ++ + A G AA + + A AA +IF
Sbjct: 310 ASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFD 369
Query: 816 LF-TYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVG 640
+ P FS K + KG + +V F Y R + IL G+NLKV G+T+ALVG
Sbjct: 370 IIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVG 429
Query: 639 PSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIREN 460
SGCGKST + L++R Y +G + ID +++ + N+N+LR + +VSQEP LF+ +I EN
Sbjct: 430 SSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAEN 489
Query: 459 LLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAIL 280
+ YG +V E++KA++ ANA+ F+ + PQ DTLVGERGAQLSGGQKQRIAIARA++
Sbjct: 490 ICYG-RGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALV 548
Query: 279 RNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKV 100
RNPK+LLLDEATSALD++SE VQ ALD A E +T+V+AHRLSTV NAD IA ++G +
Sbjct: 549 RNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVI 608
Query: 99 AEQGTHEELLRKRSIYWRLV--QKQGIQVET 13
EQG+H EL++K +Y++LV Q G Q+++
Sbjct: 609 VEQGSHSELMKKEGVYFKLVNMQTSGSQIQS 639
>gi|7511698|pir||T31073 multidrug resistance p-glycoprotein - nematode
(Haemonchus contortus)
gi|3057042|gb|AAC38987.1| P-glycoprotein [Haemonchus contortus]
Length = 1275
Score = 726 bits (1875), Expect = 0.0
Identities = 440/1247 (35%), Positives = 674/1247 (53%), Gaps = 46/1247 (3%)
Frame = -1
Query: 3633 SDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTIT 3454
S +++P I + R + ++ + L G L + G + G ++ V +
Sbjct: 26 SKKEEPPTITN--RGILSLATTLDYVLLAAGTLAPCVHGAGFSVLGIVLGGMTTVFLRAQ 83
Query: 3453 NA---INNKTIDPADLEK-AYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNT 3286
N+ + + DP L EE++ + + ++ G A F + +Q + +
Sbjct: 84 NSEFVLGTVSRDPEGLPALTKEEFDTLVRRYCLYYLGLGFAMFATSYIQIVCWETFAERI 143
Query: 3285 TYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLG 3106
T+++RK Y+ +L++ +FD TG+L+ L D+LER RE +K++L I V+ F G
Sbjct: 144 THKLRKIYLKAILRQQISWFDIQQTGNLTARLTDDLERVREGLGDKLSLFIQMVSAFVAG 203
Query: 3105 TALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKT 2926
+ F W + + + I S S V T + YA AG+IA +T + +T
Sbjct: 204 FCVGFAYSWSMTLVMMVVAPFIVISANWMSKIVATRTQVEQETYAVAGAIAEETFSSIRT 263
Query: 2925 VCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGV---------------------- 2812
V S+ G K E+ R+ L+ G + G+ + + G
Sbjct: 264 VHSICGHKRELTRFEAALEKGRQTGLVKYFYMGVGVGFGQMCTYVSYALAFWYGSVLIIN 323
Query: 2811 ----------TYFFC-----NSLNTVVLYVGATMIYSGTLETAV-VVRDDNVIEKDETDY 2680
T FF +L T + ++ I G + + + V+ I+ D
Sbjct: 324 DPALDRGRIFTVFFAVMSGSAALGTCLPHLNTISIARGAVRSVLSVINSRPKIDPYSLDG 383
Query: 2679 DVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLH 2500
V + G+I FKNV FSYP+R Q+LKG+S V G+ IALVG+SG GKST V LLL
Sbjct: 384 IVLNNMRGSIRFKNVHFSYPSRRTLQILKGVSLQVSAGQKIALVGSSGCGKSTNVNLLLR 443
Query: 2499 YYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYG 2320
+Y+ G + ID +D+ D+N+++LR IGVVSQEPVLF+ T+ ENI+ G ++ E+
Sbjct: 444 FYDPTRGKVTIDDIDVCDLNVQKLREQIGVVSQEPVLFDGTLFENIKMGYEQATMEEVQE 503
Query: 2319 ALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALD 2140
A R ANA DF P+G T VGERG QLSGGQKQRIAIAR +++NP+ILLLDEATSALD
Sbjct: 504 ACRVANAADFTKRLPEGYGTRVGERGVQLSGGQKQRIAIARAIIKNPRILLLDEATSALD 563
Query: 2139 NESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVY 1960
E+E +VQ+ALE A +GRTT++VAHRLSTIRN +I V + G IVE G H EL+ KRGV+
Sbjct: 564 TEAESIVQEALEKAQKGRTTVIVAHRLSTIRNVDQIFVFKNGTIVEQGTHAELMNKRGVF 623
Query: 1959 NDLVQAQLLESHDDHEELPPLAARQLSQ---ELSPLHSYAIQRSTSNDAGVHDDDMERIL 1789
++ QAQ+L + E L A + L L S ++ ++ A + +
Sbjct: 624 FEMTQAQVLRQEKEEEVLDSDAESDVVSPDIALPHLSSLRSRKESTRSAISAVPSVRSMQ 683
Query: 1788 DELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGE 1609
E+ AK + + +I R + + + + I G P A L + + ++ +
Sbjct: 684 IEMEDLRAKPTPMSKIFYFNRDKWGYFILGLIACIITGTVTPTFAVLYAQIIQVYSEPVD 743
Query: 1608 DMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDD 1429
M + W +F+ + + + G+ E L+ +LR ++F ++L FYDD
Sbjct: 744 QMKGHVLFWCGAFIVIGLVHAFAFFFSAICLGRCGEALTKKLRFEAFKNLLRQNVGFYDD 803
Query: 1428 PNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFP 1249
H +L R TD+ NV+ V RL V+ +VV I A+ ++ W++ L +++ P
Sbjct: 804 IRHGTGKLCTRFATDAPNVR-YVFTRLPGVLSSVVTIIGALVIGFIFGWQLALILMVMVP 862
Query: 1248 XXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQK 1069
DT E + + A +A+EN+RTV ALN +++ + E+L++
Sbjct: 863 LIIGSGYFEMRMQFGKKMRDTELLEEAGKVASQAVENIRTVHALNRQEQFHFMYCEYLKE 922
Query: 1068 IHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTAN 889
++ +A G S S F+Y+V+F G + P+D Y V
Sbjct: 923 PYRENLCQAHTYGGVFAFSQSLLFFMYAVAFWIGAIFVDNHSMQPIDVYRVFFAFMFCGQ 982
Query: 888 MAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQR 709
M G+ ++++PD KA AA L+F+L +P+ + S DG G I NV F+Y R
Sbjct: 983 MVGNISSFIPDVVKARLAASLLFYLIEHPSEIDNLSEDGVTKKISGHISFRNVYFNYPTR 1042
Query: 708 PDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLN 529
+L G+NL+++PG T+ALVG SGCGKST+++LLERFY+ G + +D EN+ ++N+
Sbjct: 1043 RQIRVLRGLNLEINPGTTVALVGQSGCGKSTVMALLERFYNQNKGVITVDGENIRNMNIR 1102
Query: 528 HLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLE-LEKALQTANAFNFVFQFPQGLDT 352
+LR + +VSQEPTLF+C+I EN+ YGL P E + A + AN NFV P+G DT
Sbjct: 1103 NLREQVCIVSQEPTLFDCTIMENICYGLDDPKPSYEQVVAAAKMANIHNFVLGLPEGYDT 1162
Query: 351 LVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLST 172
VGE+G QLSGGQKQRIAIARA++R+P +LLLDEATSALD++SEK+VQ+AL+ A + +
Sbjct: 1163 RVGEKGTQLSGGQKQRIAIARALIRDPPILLLDEATSALDTESEKIVQDALEVARQGRTC 1222
Query: 171 VVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
+V+AHRLST+ ++D I +++ GK ++GTHE LL K +Y RL + Q
Sbjct: 1223 LVIAHRLSTIQDSDVIVMIQEGKATDRGTHEHLLMKNDLYKRLCETQ 1269
Score = 286 bits (732), Expect = 3e-75
Identities = 197/626 (31%), Positives = 304/626 (48%), Gaps = 42/626 (6%)
Frame = -1
Query: 1767 AKKSNLREIVKQCRP---------------DYCFLFIAVFGSAIQGVSYPILAQL----- 1648
+KKS++ E+ K+ P DY L + G + +L +
Sbjct: 17 SKKSSIGEVSKKEEPPTITNRGILSLATTLDYVLLAAGTLAPCVHGAGFSVLGIVLGGMT 76
Query: 1647 ---------------IVRTYEGF-AMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYF 1516
+ R EG A+ E+ + L ++ L T Y Q +
Sbjct: 77 TVFLRAQNSEFVLGTVSRDPEGLPALTKEEFDTLVRRYCLYYLGLGFAMFATSYIQIVCW 136
Query: 1515 GKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVI 1336
+E+++ +LR +L +++D L+ RL D V+ + D+L I
Sbjct: 137 ETFAERITHKLRKIYLKAILRQQISWFDI--QQTGNLTARLTDDLERVREGLGDKLSLFI 194
Query: 1335 MTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTA 1156
V A Y W MTL +++ P Q + + + A
Sbjct: 195 QMVSAFVAGFCVGFAYSWSMTLVMMVVAPFIVISANWMSKIVATRTQVEQETYAVAGAIA 254
Query: 1155 IEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSF 976
E ++RTV ++ + ++ L+K ++ + G G C Y+++F
Sbjct: 255 EETFSSIRTVHSICGHKRELTRFEAALEKGRQTGLVKYFYMGVGVGFGQMCTYVSYALAF 314
Query: 975 KFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAA--AYLPDYKKAVHAAGLIFHLFTY- 805
+G+ L + + A M+GSAA LP A G + + +
Sbjct: 315 WYGSVLIINDPALDRGRIFTVFF----AVMSGSAALGTCLPHLNTISIARGAVRSVLSVI 370
Query: 804 ---PATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPS 634
P P+S N +G I +NV F Y R IL GV+L+V G+ +ALVG S
Sbjct: 371 NSRPKIDPYSLDGIVLNNMRGSIRFKNVHFSYPSRRTLQILKGVSLQVSAGQKIALVGSS 430
Query: 633 GCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLL 454
GCGKST ++LL RFY G+V ID +V D+N+ LR + +VSQEP LF+ ++ EN+
Sbjct: 431 GCGKSTNVNLLLRFYDPTRGKVTIDDIDVCDLNVQKLREQIGVVSQEPVLFDGTLFENIK 490
Query: 453 YGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRN 274
G ++ + E+++A + ANA +F + P+G T VGERG QLSGGQKQRIAIARAI++N
Sbjct: 491 MGYEQATME-EVQEACRVANAADFTKRLPEGYGTRVGERGVQLSGGQKQRIAIARAIIKN 549
Query: 273 PKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAE 94
P++LLLDEATSALD+++E +VQ AL+ A + +TV+VAHRLST+ N D I V KNG + E
Sbjct: 550 PRILLLDEATSALDTEAESIVQEALEKAQKGRTTVIVAHRLSTIRNVDQIFVFKNGTIVE 609
Query: 93 QGTHEELLRKRSIYWRLVQKQGIQVE 16
QGTH EL+ KR +++ + Q Q ++ E
Sbjct: 610 QGTHAELMNKRGVFFEMTQAQVLRQE 635
Score = 280 bits (716), Expect = 2e-73
Identities = 195/592 (32%), Positives = 299/592 (49%), Gaps = 52/592 (8%)
Frame = -1
Query: 3552 FLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQV 3373
F+LG++ ++TG P + + ++ QV Y ++Q+
Sbjct: 710 FILGLIACIITGTVTPTFAVLYAQIIQV------------------------YSEPVDQM 745
Query: 3372 VFHFFLCGCAYFIFASLQHAIMKYV--------GDNTTYRVRKQYISRLLKKDAQYFDSV 3217
H L C FI L HA + G+ T ++R + LL+++ ++D +
Sbjct: 746 KGHV-LFWCGAFIVIGLVHAFAFFFSAICLGRCGEALTKKLRFEAFKNLLRQNVGFYDDI 804
Query: 3216 --STGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLG 3043
TG L T + R VF ++ +++ V + F W+LA +
Sbjct: 805 RHGTGKLCTRFATDAPNVRYVFT-RLPGVLSSVVTIIGALVIGFIFGWQLALILMVMVPL 863
Query: 3042 IAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAG 2863
I SG+ + AG +A Q + +TV +LN Q+ Y E LK
Sbjct: 864 IIGSGYFEMRMQFGKKMRDTELLEEAGKVASQAVENIRTVHALNRQEQFHFMYCEYLKEP 923
Query: 2862 EKYGIRRALMYSISRGVTYFFCNSL----NTVVLYVGATMIYSGTLETAVVVRD------ 2713
+ + +A Y G + F SL V ++GA + + +++ V R
Sbjct: 924 YRENLCQAHTY----GGVFAFSQSLLFFMYAVAFWIGAIFVDNHSMQPIDVYRVFFAFMF 979
Query: 2712 -----------------------------DNVIEKDETDYD-VEVEVNGNISFKNVKFSY 2623
++ E D D V +++G+ISF+NV F+Y
Sbjct: 980 CGQMVGNISSFIPDVVKARLAASLLFYLIEHPSEIDNLSEDGVTKKISGHISFRNVYFNY 1039
Query: 2622 PTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDM 2443
PTR +VL+G++ ++ G +ALVG SG GKSTV+ LL +YN + G I +DG ++ +M
Sbjct: 1040 PTRRQIRVLRGLNLEINPGTTVALVGQSGCGKSTVMALLERFYNQNKGVITVDGENIRNM 1099
Query: 2442 NIKRLRRVIGVVSQEPVLFNTTIEENIRFG--NPNVSLPEIYGALRKANAYDFVCSFPKG 2269
NI+ LR + +VSQEP LF+ TI ENI +G +P S ++ A + AN ++FV P+G
Sbjct: 1100 NIRNLREQVCIVSQEPTLFDCTIMENICYGLDDPKPSYEQVVAAAKMANIHNFVLGLPEG 1159
Query: 2268 IKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQG 2089
T VGE+GTQLSGGQKQRIAIAR L+R+P ILLLDEATSALD ESE++VQ ALE A QG
Sbjct: 1160 YDTRVGEKGTQLSGGQKQRIAIARALIRDPPILLLDEATSALDTESEKIVQDALEVARQG 1219
Query: 2088 RTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLL 1933
RT +V+AHRLSTI+++ I+++Q+G+ + G H+ L+ K +Y L + Q L
Sbjct: 1220 RTCLVIAHRLSTIQDSDVIVMIQEGKATDRGTHEHLLMKNDLYKRLCETQRL 1271
>gi|6981354|ref|NP_036822.1| ATP-binding cassette, sub-family B
(MDR/TAP), member 4; ATP-binding cassette, sub-family B
(MDR/TAP), member 4 (P-glycoprotein 3/ multidrug
resistance 2); ATP-binding cassette sub-family B
(MDR/TAP) member 4 (P-glycoprotein 3/ multidrug
resistance 2); P-glycoprotein 3/ multidrug resistance 2;
ATP-binding cassette sub-family B (MDR/TAP) member 4
(P-glycoprotein 3/ multidrug resistance 2 [Rattus
norvegicus]
gi|1170903|sp|Q08201|MDR2_RAT Multidrug resistance protein 2
(P-glycoprotein 2)
gi|543425|pir||S41646 p-glycoprotein - rat
gi|310193|gb|AAA02937.1| P-glycoprotein
Length = 1278
Score = 724 bits (1870), Expect = 0.0
Identities = 447/1249 (35%), Positives = 680/1249 (53%), Gaps = 47/1249 (3%)
Frame = -1
Query: 3636 QSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTI 3457
QS EKK +F+ S +K LLG ++ G P M FGE++ V
Sbjct: 26 QSREKKKKVNLIGPLTLFRYSDWQDKLFMLLGTAMAIAHGSGLPLMMIVFGEMTDKFVDN 85
Query: 3456 TNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYR 3277
+ + E M + +++ G + A +Q + +
Sbjct: 86 AGNFSLPVNFSLSMLNPGRILEEEMTRYAYYYSGLGGGVLLAAYIQVSFWTLAAGRQIRK 145
Query: 3276 VRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTAL 3097
+R+++ +L+++ +FD T L+T L D++ + E +K+ + + F G +
Sbjct: 146 IRQKFFHAILRQEMGWFDIKGTTELNTRLTDDISKISEGIGDKVGMFFQAIATFFAGFIV 205
Query: 3096 AFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCS 2917
F W+L + + + S + + + + K+ YA AG++A + LGA +TV +
Sbjct: 206 GFIRGWKLTLVIMAITAILGLSTAVWAKILSTFSDKELAAYAKAGAVAEEALGAIRTVIA 265
Query: 2916 LNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYSG-- 2743
GQ E+ERY + L+ +K GI++A+ +IS G+ + + + + G+T++ S
Sbjct: 266 FGGQNKELERYQKHLENAKKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEY 325
Query: 2742 TLETAVVV------------------------RDDNVIEKDETDYDVEVE---------- 2665
T+ A+ V R + D D + +++
Sbjct: 326 TIGNAMTVFFSILIGAFSVGQAAPCIDAFPNARGAAYVIFDIIDNNPKIDSFSERGHKPD 385
Query: 2664 -VNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNI 2488
+ GN+ F +V FSYP+R + ++LKG++ V++G+ +ALVG SG GKST VQLL Y+
Sbjct: 386 SIKGNLEFSDVHFSYPSRANIKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDP 445
Query: 2487 DSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRK 2308
G I IDG D+ + N++ LR IGVVSQEPVLF+TTI ENIR+G NV++ EI A+++
Sbjct: 446 TEGTISIDGQDIRNFNVRCLREFIGVVSQEPVLFSTTIAENIRYGRGNVTMDEIKKAVKE 505
Query: 2307 ANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESE 2128
ANAYDF+ P+ T+VG+RG QLSGGQKQRIAIAR LVRNPKILLLDEATSALD ESE
Sbjct: 506 ANAYDFIMKLPQKFDTLVGDRGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESE 565
Query: 2127 QVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLV 1948
VQ AL+ A +GRTTIV+AHRLST+RNA I + G IVE G+H ELI K G+Y LV
Sbjct: 566 AEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELIKKEGIYFRLV 625
Query: 1947 QAQLLESHDDHEELP-PLAARQLSQELSP--LHSYAIQRSTS---NDAGVHDDDMERILD 1786
Q S EE L+ + + ++P + + ST + H + ++ +
Sbjct: 626 NMQTSGSQILSEEFEVELSDEKAAGGVAPNGWKARIFRNSTKKSLKSSRAHQNRLDVETN 685
Query: 1785 ELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGED 1606
EL S L+ +++ + ++ + + + G P + ++ F G+D
Sbjct: 686 ELDANVPPVSFLK-VLRLNKTEWPYFVVGTLCAIANGALQPAFSIILSEMIAIFGP-GDD 743
Query: 1605 MLYYS--HLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYD 1432
+ ++++L F+ L V T + Q + FGK E L+TRLR +F ML +++D
Sbjct: 744 TVKQQKCNMFSLVFLGLGVHSFFTFFLQGFTFGKAGEILTTRLRSMAFKAMLRQDMSWFD 803
Query: 1431 DPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFF 1252
D +S LS RL TD++ V+ A RL + + I + +Y W++TL +L
Sbjct: 804 DHKNSTGALSTRLATDAAQVQGATGTRLALIAQNTANLGTGIIISFIYGWQLTLLLLSVV 863
Query: 1251 PXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQ 1072
P + D E + + A EA+EN+RTV +L E K S+ E L
Sbjct: 864 PFIAVAGIVEMKMLAGNAKRDKKEMEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLH 923
Query: 1071 KIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTA 892
+++ ++A I G +S + F Y+ F+FG+YL + + D LV + + A
Sbjct: 924 GPYRNSVRKAHIYGITFSISQAFMYFSYAGCFRFGSYLIVNGHMRFKDVILVFSAIVLGA 983
Query: 891 NMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGK-KNIEKGEIIGENVQFHYD 715
G A+++ PDY KA +A +F LF + S +G + +G + V F+Y
Sbjct: 984 VALGHASSFAPDYAKAKLSAAYLFSLFERQPLIDSYSREGMWPDKFEGSVTFNEVVFNYP 1043
Query: 714 QRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDIN 535
R + +L G++L+V G+TLALVG SGCGKST++ LLERFY + G V +D + + +N
Sbjct: 1044 TRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVLLDGQEAKKLN 1103
Query: 534 LNHLRSNLALVSQEPTLFNCSIRENLLYG-LTRSVPQLELEKALQTANAFNFVFQFPQGL 358
+ LR+ L +VSQEP LF+CSI +N+ YG +R V Q E+ +A + AN F+ PQ
Sbjct: 1104 VQWLRAQLGIVSQEPILFDCSIAKNIAYGDNSRVVSQDEIVRAAKEANIHPFIETLPQKY 1163
Query: 357 DTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERL 178
+T VG++G QLSGGQKQRIAIARA++R P+VLLLDEATSALD++SEKVVQ ALD A E
Sbjct: 1164 ETRVGDKGTQLSGGQKQRIAIARALIRQPRVLLLDEATSALDTESEKVVQEALDKAREGR 1223
Query: 177 STVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
+ +V+AHRLST+ NAD I V+ NGKV E GTH++LL ++ IY+ +V Q
Sbjct: 1224 TCIVIAHRLSTIQNADLIVVIDNGKVKEHGTHQQLLAQKGIYFSMVNIQ 1272
>gi|27656757|gb|AAO20901.1| Mdr3 [Takifugu rubripes]
Length = 1292
Score = 722 bits (1864), Expect = 0.0
Identities = 445/1272 (34%), Positives = 677/1272 (52%), Gaps = 73/1272 (5%)
Frame = -1
Query: 3627 EKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNA 3448
EK P + +F+ + ++ L + G + +++ G P M FGE++ + A
Sbjct: 34 EKPPQEPMVGPITLFRFADRWDVVLLISGTVMAMVNGTVMPLMCIVFGEMTDSFIYADMA 93
Query: 3447 INNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRK 3268
+N + + + M + ++ + G + A +Q + R+R
Sbjct: 94 QHNASGWNSTTTILNSTLQEDMQRFAIYYSVLGFVVLLAAYMQVSFWTITAGRQVKRIRS 153
Query: 3267 QYISRLLKKDAQYFDSVSTGHLSTVLND------------------------------NL 3178
+ +++++ +FD TG L+T L + ++
Sbjct: 154 LFFHCIMQQEISWFDVNDTGELNTRLTEEFPASAFTLCTATLGGVDDLMDVLLFSNGSDV 213
Query: 3177 ERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKT 2998
+ +E +K+ L+I T F + F T W+L + S +A S S +
Sbjct: 214 YKIQEGIGDKVGLLIQAYTTFITAFIIGFTTGWKLTLVILAVSPALAISAAFFSKVLASF 273
Query: 2997 TGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISR 2818
T K+ T YA AG++A + L A +TV + +GQ EIERY + L+ + G+++A+ +I+
Sbjct: 274 TSKEQTAYAKAGAVAEEVLSAIRTVFAFSGQTREIERYHKNLRDAKDVGVKKAISSNIAM 333
Query: 2817 GVTYFFCNSLNTVVLYVGATMIYS-----GTLET-------------------------- 2731
G T+ + + G+T+I + G L T
Sbjct: 334 GFTFLMIYLSYALAFWYGSTLILNFEYTIGNLLTVFFVVLIGAFSVGQTSPNIQNFASAR 393
Query: 2730 -------AVVVRDDNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQ 2572
+++ N+ E + + + G+I FKN+ F+YP+RP+ ++L +S V+
Sbjct: 394 GAAYKVYSIIDNKPNIDSFSEDGFKPDF-IKGDIEFKNIHFNYPSRPEVKILNNMSLSVK 452
Query: 2571 NGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPV 2392
+G+ IALVG+SG GKST +QLL +Y+ + G +FIDG D+ +NI+ LR +IGVVSQEPV
Sbjct: 453 SGQTIALVGSSGCGKSTTIQLLQRFYDPEEGAVFIDGHDIRSLNIRYLREMIGVVSQEPV 512
Query: 2391 LFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQR 2212
LF TTI ENIR+G +V+ EI A +++NAYDF+ + P +T+VG+RGTQLSGGQKQR
Sbjct: 513 LFATTITENIRYGRLDVTQEEIERATKESNAYDFIMNLPDKFETLVGDRGTQLSGGQKQR 572
Query: 2211 IAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKI 2032
IAIAR LVRNPKILLLDEATSALD ESE +VQ AL+ GRTTIVVAHRLSTIRNA I
Sbjct: 573 IAIARALVRNPKILLLDEATSALDAESETIVQAALDKVRLGRTTIVVAHRLSTIRNADII 632
Query: 2031 IVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLES-HDDHEELPPLAARQLSQ-ELSPLH 1858
G+IVE G H +L+ +GVY+ LV Q + +++ + L+A + S E +
Sbjct: 633 AGFSNGKIVEQGTHSQLMEIKGVYHGLVTMQTFHNVEEENTAMSELSAGEKSPVEKTVSQ 692
Query: 1857 SYAIQRSTSNDAGVHDDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQ 1678
S I+R ++ + + + E + +++ P++ ++ + + + I
Sbjct: 693 SSIIRRKSTRGSSFAASEGTKEEKTEEDEDVPDVSFFKVLHLNIPEWPYILVGLICATIN 752
Query: 1677 GVSYPILAQLIVRTYEGFAMIGEDML-YYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSE 1501
G P+ A L + FA D + S +L F+ + +T++ Q Y FGK E
Sbjct: 753 GAMQPVFAILFSKIITVFADPDRDSVRRKSEFISLMFVVIGCVSFVTMFLQGYCFGKSGE 812
Query: 1500 QLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVA 1321
L+ +LR+++F+ M+ ++YD+P ++ L+ RL D++ V+ A RL ++
Sbjct: 813 ILTLKLRLRAFTAMMRQDLSWYDNPQNTVGALTTRLAADAAQVQGAAGVRLATIMQNFAN 872
Query: 1320 ISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALE 1141
+ +I A +Y W++TL +L P +D E + + A EA+E
Sbjct: 873 LGTSIIIAFVYGWELTLLILAVVPLIAAAGAAEIKLLAGHAAKDKKELEKAGKIATEAIE 932
Query: 1140 NVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTY 961
NVRTV +L+ E K L E+L+ +K+ K+A + G S + F Y+ F+FG +
Sbjct: 933 NVRTVVSLSREPKFECLYEENLRVPYKNSQKKAHVYGLTYSFSQAMIYFAYAACFRFGAW 992
Query: 960 LALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFT-YPATMPFS 784
L + +LV+ + A G A + P+Y KA AA + L PA S
Sbjct: 993 LIEAGRMDVEGVFLVVSAVLYGAMAVGEANTFAPNYAKAKMAASYLMMLINKKPAIDNLS 1052
Query: 783 SSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISL 604
G + E V+F+Y RPD IL G+NLKV G+TLALVG SGCGKST I L
Sbjct: 1053 EEGTSPEKYDGNVHFEGVKFNYPSRPDVTILQGLNLKVKKGETLALVGSSGCGKSTTIQL 1112
Query: 603 LERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYG-LTRSVPQ 427
LERFY +G V +D NV+ +N++ LRS + +VSQEP LF+CS+ EN+ YG +RSV
Sbjct: 1113 LERFYDPREGRVSLDGVNVKQLNIHWLRSQIGIVSQEPVLFDCSLAENIAYGDNSRSVSM 1172
Query: 426 LELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEA 247
E+ DT G++G QLSGGQKQR+AIARAI+RNPK+LLLDEA
Sbjct: 1173 DEIR------------------YDTQAGDKGTQLSGGQKQRVAIARAIIRNPKLLLLDEA 1214
Query: 246 TSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLR 67
TSALD++SEKVVQ ALD A + + +VVAHRLST+ NAD IAV + G V E+GTH++L+
Sbjct: 1215 TSALDTESEKVVQEALDQARKGRTCIVVAHRLSTIQNADCIAVFQGGVVVEKGTHQQLIA 1274
Query: 66 KRSIYWRLVQKQ 31
K+ +Y LV KQ
Sbjct: 1275 KKGVYHMLVTKQ 1286
Score = 277 bits (709), Expect = 1e-72
Identities = 195/579 (33%), Positives = 298/579 (50%), Gaps = 41/579 (7%)
Frame = -1
Query: 3549 LLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQVV 3370
L+G++ + + G QP + F ++ V AD ++ + R +
Sbjct: 743 LVGLICATINGAMQPVFAILFSKIITVF--------------ADPDR--DSVRRKSEFIS 786
Query: 3369 FHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSV--STGHLST 3196
F + GC F+ LQ G+ T ++R + + ++++D ++D+ + G L+T
Sbjct: 787 LMFVVIGCVSFVTMFLQGYCFGKSGEILTLKLRLRAFTAMMRQDLSWYDNPQNTVGALTT 846
Query: 3195 VLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINS 3016
L + + + ++A I+ + +AF W L + IA +G
Sbjct: 847 RLAADAAQVQGAAGVRLATIMQNFANLGTSIIIAFVYGWELTLLILAVVPLIAAAGAAEI 906
Query: 3015 AGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRA- 2839
+ K AG IA + + +TV SL+ + Y E L+ K ++A
Sbjct: 907 KLLAGHAAKDKKELEKAGKIATEAIENVRTVVSLSREPKFECLYEENLRVPYKNSQKKAH 966
Query: 2838 ---LMYSISRGVTYFF---CNSLNTVVLYVGAT------MIYSGTLETAVVVRDDN---- 2707
L YS S+ + YF C ++ G ++ S L A+ V + N
Sbjct: 967 VYGLTYSFSQAMIYFAYAACFRFGAWLIEAGRMDVEGVFLVVSAVLYGAMAVGEANTFAP 1026
Query: 2706 --------------VIEKDETDYDVEVE------VNGNISFKNVKFSYPTRPDAQVLKGI 2587
+I K ++ E +GN+ F+ VKF+YP+RPD +L+G+
Sbjct: 1027 NYAKAKMAASYLMMLINKKPAIDNLSEEGTSPEKYDGNVHFEGVKFNYPSRPDVTILQGL 1086
Query: 2586 SFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVV 2407
+ V+ GE +ALVG+SG GKST +QLL +Y+ G + +DG+++ +NI LR IG+V
Sbjct: 1087 NLKVKKGETLALVGSSGCGKSTTIQLLERFYDPREGRVSLDGVNVKQLNIHWLRSQIGIV 1146
Query: 2406 SQEPVLFNTTIEENIRFGNPN--VSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQL 2233
SQEPVLF+ ++ ENI +G+ + VS+ EI YD T G++GTQL
Sbjct: 1147 SQEPVLFDCSLAENIAYGDNSRSVSMDEI--------RYD----------TQAGDKGTQL 1188
Query: 2232 SGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLST 2053
SGGQKQR+AIAR ++RNPK+LLLDEATSALD ESE+VVQ+AL+ A +GRT IVVAHRLST
Sbjct: 1189 SGGQKQRVAIARAIIRNPKLLLLDEATSALDTESEKVVQEALDQARKGRTCIVVAHRLST 1248
Query: 2052 IRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQL 1936
I+NA I V Q G +VE G H +LIAK+GVY+ LV Q+
Sbjct: 1249 IQNADCIAVFQGGVVVEKGTHQQLIAKKGVYHMLVTKQM 1287
>gi|45361353|ref|NP_989254.1| hypothetical protein MGC76216 [Xenopus
tropicalis]
gi|39645391|gb|AAH63924.1| Hypothetical protein MGC76216 [Xenopus
tropicalis]
Length = 1261
Score = 722 bits (1863), Expect = 0.0
Identities = 437/1245 (35%), Positives = 675/1245 (54%), Gaps = 41/1245 (3%)
Frame = -1
Query: 3636 QSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTI 3457
++++ K QI I + F+ + + FL ++G L ++ G C P M+ FGE+S +
Sbjct: 27 ENEKNKQEQIIGPISI-FQFADWLDIFLMIIGTLGAIGCGSCYPLMNVVFGEMSDSFLCH 85
Query: 3456 TNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYR 3277
+++ N + ++ E + + ++ G A LQ + T +
Sbjct: 86 NSSLQNSSACAK-----FKPIEEEIQKFSLYYAGLGFAVLFCGYLQVSCWVVAASRQTRK 140
Query: 3276 VRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTAL 3097
+RK + +L ++ +FD +G L+T L +N+ + + +K+A T G +
Sbjct: 141 MRKAFFHSVLSQEIGWFDVTKSGDLNTRLTENINKINDGIGDKVAHFFQNTTICVSGILI 200
Query: 3096 AFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCS 2917
W+LA + S + + + S V+ T K+ YA AG++A + L + +TV +
Sbjct: 201 GLIQGWKLALVILATSPVLTLASAMFSRIVVSLTTKELAAYAKAGAVAQEVLSSIRTVVA 260
Query: 2916 LNGQKTEIERYTEELKAGEKYGIRRALM-------------------------------- 2833
G++ EI+RYTE LK + GI++++
Sbjct: 261 FGGEEKEIKRYTENLKQAKDIGIKKSIASQFALGLVNGAFYATYGVGFWYGTTLVLEDDD 320
Query: 2832 YSISRGVTYFFCNSLNTVVLYVGATMIYSGTLETAV------VVRDDNVIEKDETDYDVE 2671
Y+I + FF S ++ + A+ + + A V++ + I+ D
Sbjct: 321 YTIGDVMAVFFNVSFSSYAIGQAASHFEAFHIARAAASSIFKVIKQSSSIDNFSNDGFKP 380
Query: 2670 VEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYN 2491
+ GNI K++ FSYP+RP +VL G++ V++G+ +ALVG SG GKST+VQLL Y+
Sbjct: 381 DNIKGNIELKDIYFSYPSRPGVKVLNGLNLSVKSGQTVALVGQSGCGKSTIVQLLQRLYD 440
Query: 2490 IDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALR 2311
G + +DG D+ +N+ R +IGVVSQEPVLF TTI++NIR+G +V+ EI A++
Sbjct: 441 PKEGTLAVDGHDIKSLNVTYYRELIGVVSQEPVLFGTTIKQNIRYGRDDVTDEEIEKAVK 500
Query: 2310 KANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNES 2131
+ANAYDF+ + P +T+VGERG QLSGGQKQRIA+AR LVRNPKILLLDEATSALD S
Sbjct: 501 EANAYDFIMALPDKYETLVGERGAQLSGGQKQRIAVARALVRNPKILLLDEATSALDTGS 560
Query: 2130 EQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDL 1951
E VVQ AL+ A +GRTTIVVAHRLSTI A I+V+ G + E G H EL+ K+G+Y L
Sbjct: 561 EAVVQAALDKARKGRTTIVVAHRLSTIWTADVIVVIDNGAVAEQGTHSELMEKKGIYFSL 620
Query: 1950 VQAQLLESHDDHEELPPLAARQLSQELSPLHSYAIQRSTSNDAGVHDDDMERILDELSKE 1771
AQ ++ DD+E + ++ S + + Q S + + D+D E E SK+
Sbjct: 621 ATAQTVQLSDDNETTEKNQNGIIYEKASLIQRFNSQTSLKSKI-LEDEDEE----EESKK 675
Query: 1770 GAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIG-EDMLYY 1594
+ +++K R ++ ++ + + + + G P+ R FA E +
Sbjct: 676 DLPTVSFFQLLKLNRSEWPYILLGIIAAGVIGSLLPLFCIFYARIIAVFASNDPETIRKE 735
Query: 1593 SHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSA 1414
S L +L F V L + Y FG+ E L+ RLR +F M+ A++DD +++
Sbjct: 736 SDLCSLIFGLTGVVILLAYIARGYMFGRSGETLTMRLRHMAFKAMIQQDIAWFDDKDNNT 795
Query: 1413 TRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXX 1234
L+ RL TD+S ++ A RLG + ++ I + + A +Y W++ L L P
Sbjct: 796 GALTTRLATDASEIQTATGYRLGFLAENLIGIVLTVIIAFVYGWELALLGLAMAPFMVIC 855
Query: 1233 XXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSY 1054
D + + + A EA++N+RT+ +L E + SE LQK +++
Sbjct: 856 GLLEFSALTGFATRDKKQLQRAGKIATEAVDNIRTLVSLTRERTFEEMYSESLQKPYRNS 915
Query: 1053 FKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSA 874
++A I G + + + F ++ F FG YL + + + LV ++ A G+
Sbjct: 916 LRKAQIYGLYFAIGHAFYYFTHAALFCFGAYLIKYERINVEEALLVFSVITFGAMTLGTT 975
Query: 873 AAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKK-NIEKGEIIGENVQFHYDQRPDRM 697
+ PDY KA AA +F LF + SS G+K + G + NV F+Y R D
Sbjct: 976 LTFAPDYAKATSAARYLFALFESKPAIDSSSQQGQKPDCFSGSLEFRNVSFNYPTRSDVR 1035
Query: 696 ILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRS 517
+L + +KV+ G+T+A VG SGCGKST + LL+RFY +GEV +D + + N+ LRS
Sbjct: 1036 VLRDLCVKVESGQTVAFVGSSGCGKSTSVQLLQRFYDPKEGEVLLDDVDAKCFNVQWLRS 1095
Query: 516 NLALVSQEPTLFNCSIRENLLYG-LTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGE 340
+ +VSQEP LF+CSI EN+ YG +R+V E++ A + AN +F+ P +TLVG
Sbjct: 1096 QMGIVSQEPVLFDCSIAENIAYGDNSRTVSMDEIQSAAKAANIHSFIEGLPLKYETLVGA 1155
Query: 339 RGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVA 160
+G QLSGGQKQRIAIARA++R PK+LLLDEATSALD++SEKVVQ ALD A + + +++A
Sbjct: 1156 KGTQLSGGQKQRIAIARALIRAPKILLLDEATSALDNESEKVVQQALDQARKGRTCILIA 1215
Query: 159 HRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGI 25
HRL+TV NAD I V+ GK+ E G+H+ELL K Y+ LV Q I
Sbjct: 1216 HRLTTVQNADIIVVMNKGKIIEHGSHQELLAKCGAYYDLVNAQAI 1260
Score = 321 bits (823), Expect = 7e-86
Identities = 196/518 (37%), Positives = 288/518 (54%), Gaps = 6/518 (1%)
Frame = -1
Query: 1539 LYCQYYYFG--KVSEQLSTRLRIKSFSH-MLSLPCAFYDDPNHSATRLSNRLNTDSSNVK 1369
L+C Y V+ TR K+F H +LS ++D L+ RL + + +
Sbjct: 120 LFCGYLQVSCWVVAASRQTRKMRKAFFHSVLSQEIGWFDVTKSGD--LNTRLTENINKIN 177
Query: 1368 AAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQED 1189
+ D++ I + WK+ L +L P ++
Sbjct: 178 DGIGDKVAHFFQNTTICVSGILIGLIQGWKLALVILATSPVLTLASAMFSRIVVSLTTKE 237
Query: 1188 TIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSL 1009
A+ + A E L ++RTV A E+K + +E+L++ K++I A GL
Sbjct: 238 LAAYAKAGAVAQEVLSSIRTVVAFGGEEKEIKRYTENLKQAKDIGIKKSIASQFALGLVN 297
Query: 1008 SCFLFVYSVSFKFGTYLALRKEVAPM-DTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAA 832
F Y V F +GT L L + + D V +S ++ G AA++ + A AA
Sbjct: 298 GAFYATYGVGFWYGTTLVLEDDDYTIGDVMAVFFNVSFSSYAIGQAASHFEAFHIARAAA 357
Query: 831 GLIFHLFTYPATMPFSSSDGKK--NIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGK 658
IF + +++ S+DG K NI KG I +++ F Y RP +LNG+NL V G+
Sbjct: 358 SSIFKVIKQSSSIDNFSNDGFKPDNI-KGNIELKDIYFSYPSRPGVKVLNGLNLSVKSGQ 416
Query: 657 TLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFN 478
T+ALVG SGCGKSTI+ LL+R Y +G + +D +++ +N+ + R + +VSQEP LF
Sbjct: 417 TVALVGQSGCGKSTIVQLLQRLYDPKEGTLAVDGHDIKSLNVTYYRELIGVVSQEPVLFG 476
Query: 477 CSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIA 298
+I++N+ YG V E+EKA++ ANA++F+ P +TLVGERGAQLSGGQKQRIA
Sbjct: 477 TTIKQNIRYGRD-DVTDEEIEKAVKEANAYDFIMALPDKYETLVGERGAQLSGGQKQRIA 535
Query: 297 IARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAV 118
+ARA++RNPK+LLLDEATSALD+ SE VVQ ALD A + +T+VVAHRLST+ AD I V
Sbjct: 536 VARALVRNPKILLLDEATSALDTGSEAVVQAALDKARKGRTTIVVAHRLSTIWTADVIVV 595
Query: 117 LKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQVETPSD 4
+ NG VAEQGTH EL+ K+ IY+ L Q +Q+ ++
Sbjct: 596 IDNGAVAEQGTHSELMEKKGIYFSLATAQTVQLSDDNE 633
>gi|9961250|ref|NP_061337.1| ATP-binding cassette, subfamily B, member
4 isoform B; P glycoprotein 3/multiple drug resistance 3;
P-glycoprotein-3/multiple drug resistance-3; multiple
drug resistance 3 [Homo sapiens]
Length = 1286
Score = 721 bits (1860), Expect = 0.0
Identities = 443/1249 (35%), Positives = 674/1249 (53%), Gaps = 60/1249 (4%)
Frame = -1
Query: 3597 IRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPAD 3418
+ +F+ S +K LG + ++ G P M FGE++ V +
Sbjct: 42 VLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLS 101
Query: 3417 LEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKD 3238
L + E M + +++ G + A +Q + ++R+++ +L+++
Sbjct: 102 LLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQE 161
Query: 3237 AQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGI 3058
+FD T L+T L D++ + E +K+ + V F G + F W+L +
Sbjct: 162 IGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIM 221
Query: 3057 FFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTE 2878
S + S + + + + K+ YA AG++A + LGA +TV + GQ E+ERY +
Sbjct: 222 AISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQK 281
Query: 2877 ELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYSG--TLETAVVV----- 2719
L+ ++ GI++A+ +IS G+ + + + + G+T++ S T+ A+ V
Sbjct: 282 HLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSIL 341
Query: 2718 -------------------RDDNVIEKDETDYDVEVE-----------VNGNISFKNVKF 2629
R + D D + +++ + GN+ F +V F
Sbjct: 342 IGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHF 401
Query: 2628 SYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLN 2449
SYP+R + ++LKG++ VQ+G+ +ALVG+SG GKST VQL+ Y+ D G I IDG D+
Sbjct: 402 SYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIR 461
Query: 2448 DMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKG 2269
+ N+ LR +IGVVSQEPVLF+TTI ENI +G NV++ EI A+++ANAY+F+ P+
Sbjct: 462 NFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQK 521
Query: 2268 IKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQG 2089
T+VGERG QLSGGQKQRIAIAR LVRNPKILLLDEATSALD ESE VQ AL+ A +G
Sbjct: 522 FDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREG 581
Query: 2088 RTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLESHDDHEE 1909
RTTIV+AHRLST+RNA I + G IVE G+H EL+ K GVY LV Q S EE
Sbjct: 582 RTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEE 641
Query: 1908 LPPLAARQLSQELSP------LHSYAIQRSTSN------DAGVHDDDMERILDELSKEGA 1765
L + + ++P L ++ Q++ N V D +E + +S
Sbjct: 642 F-ELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVS---- 696
Query: 1764 KKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYYS-- 1591
+++K + ++ + + + G P + + F G+D +
Sbjct: 697 ----FLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGP-GDDAVKQQKC 751
Query: 1590 HLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSAT 1411
++++L F+FL + T + Q + FGK E L+ RLR +F ML +++DD +S
Sbjct: 752 NIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTG 811
Query: 1410 RLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXX 1231
LS RL TD++ V+ A RL + + + I + +Y W++TL +L P
Sbjct: 812 ALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSG 871
Query: 1230 XXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYF 1051
+ D E + + A EA+EN+RTV +L E K S+ E L +++
Sbjct: 872 IVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSV 931
Query: 1050 KRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAA 871
++A I G +S + F Y+ F+FG YL + + D LV + A G A+
Sbjct: 932 QKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHAS 991
Query: 870 AYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDG-KKNIEKGEIIGENVQFHYDQRPDRMI 694
++ PDY KA +A +F LF + S +G K + +G I V F+Y R + +
Sbjct: 992 SFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPV 1051
Query: 693 LNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEV-------KIDSENVEDIN 535
L G++L+V G+TLALVG SGCGKST++ LLERFY + G V +D + + +N
Sbjct: 1052 LQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLN 1111
Query: 534 LNHLRSNLALVSQEPTLFNCSIRENLLYG-LTRSVPQLELEKALQTANAFNFVFQFPQGL 358
+ LR+ L +VSQEP LF+CSI EN+ YG +R V Q E+ A + AN F+ P
Sbjct: 1112 VQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKY 1171
Query: 357 DTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERL 178
+T VG++G QLSGGQKQRIAIARA++R P++LLLDEATSALD++SEKVVQ ALD A E
Sbjct: 1172 ETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGR 1231
Query: 177 STVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
+ +V+AHRLST+ NAD I V +NG+V E GTH++LL ++ IY+ +V Q
Sbjct: 1232 TCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ 1280
Score = 330 bits (847), Expect = 1e-88
Identities = 191/511 (37%), Positives = 290/511 (56%), Gaps = 3/511 (0%)
Frame = -1
Query: 1536 YCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVD 1357
Y Q ++ + + ++R K F +L ++D + T L+ RL D S + +
Sbjct: 132 YIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDI--NDTTELNTRLTDDISKISEGIG 189
Query: 1356 DRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAF 1177
D++G V + WK+TL ++ P ++ A+
Sbjct: 190 DKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAY 249
Query: 1176 ENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFL 997
+ A EAL +RTV A ++K + +HL+ + K+AI + G++
Sbjct: 250 AKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIY 309
Query: 996 FVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFH 817
Y+++F +G+ L + KE + V ++ + A G AA + + A AA +IF
Sbjct: 310 ASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFD 369
Query: 816 LF-TYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVG 640
+ P FS K + KG + +V F Y R + IL G+NLKV G+T+ALVG
Sbjct: 370 IIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVG 429
Query: 639 PSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIREN 460
SGCGKST + L++R Y +G + ID +++ + N+N+LR + +VSQEP LF+ +I EN
Sbjct: 430 SSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAEN 489
Query: 459 LLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAIL 280
+ YG +V E++KA++ ANA+ F+ + PQ DTLVGERGAQLSGGQKQRIAIARA++
Sbjct: 490 ICYG-RGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALV 548
Query: 279 RNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKV 100
RNPK+LLLDEATSALD++SE VQ ALD A E +T+V+AHRLSTV NAD IA ++G +
Sbjct: 549 RNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVI 608
Query: 99 AEQGTHEELLRKRSIYWRLV--QKQGIQVET 13
EQG+H EL++K +Y++LV Q G Q+++
Sbjct: 609 VEQGSHSELMKKEGVYFKLVNMQTSGSQIQS 639
>gi|283552|pir||S27338 P-glycoprotein C - Caenorhabditis elegans
gi|6811|emb|CAA46191.1| P-glycoprotein C [Caenorhabditis elegans]
Length = 1254
Score = 711 bits (1836), Expect = 0.0
Identities = 419/1241 (33%), Positives = 682/1241 (54%), Gaps = 55/1241 (4%)
Frame = -1
Query: 3588 VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEK 3409
VF+ + + LF G++ S + G PF S F ++ L+ + N TI+
Sbjct: 34 VFRDADYKDYILFSGGLILSAVNGALVPFNSLIFEGIANALMEGESQYQNGTIN------ 87
Query: 3408 AYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQY 3229
+ + +F G A F+ + ++ + + + + +RK+Y+ +L++DA++
Sbjct: 88 -MPWFSSEIKMFCLRYFYLGVALFLCSYFANSCLYTLCERRLHCIRKKYLKSVLRQDAKW 146
Query: 3228 FDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFS 3049
FD + G L+ ++ +E+ ++ +K+ +++ V F G ++ FY W+L +
Sbjct: 147 FDETTIGGLTQKMSSGIEKIKDGIGDKVGVLVGGVATFISGVSIGFYMCWQLTLVMMITV 206
Query: 3048 LGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELK 2869
S ++++ + + T + + Y+NAG +A + + +TV + N Q EI RY +L
Sbjct: 207 PLQLGSMYLSAKHLNRATKNEMSAYSNAGGMANEVIAGIRTVMAFNAQPFEINRYAHQLN 266
Query: 2868 AGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYSGTLETAVV----------- 2722
+ GIR+A++ +I + V + GAT+ +G + + V
Sbjct: 267 EARRMGIRKAIILAICTAFPLMLMFTCMAVAFWYGATLAAAGAVSSGAVFAVFWAVLIGT 326
Query: 2721 --------------------------VRDDNVIEKDETDYDVEVEVNGNISFKNVKFSYP 2620
+ + I+ ++ + ++ G ++F ++F+YP
Sbjct: 327 RRLGEAAPHLGAITGARLAIHDIFKVIDHEPEIKCTSSEGKIPEKIQGKLTFDGIEFTYP 386
Query: 2619 TRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMN 2440
TRP+ ++LKG+SF+V GE +ALVG SG GKST + LL+ +YN +G I +DG+ + + N
Sbjct: 387 TRPELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYN 446
Query: 2439 IKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKT 2260
I+ LR IG+V QEP++F T+ ENIR G+ ++ +I A + ANA++F+C T
Sbjct: 447 IRWLRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDT 506
Query: 2259 IVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTT 2080
++G QLSGGQKQR+AIAR +VR P+ILLLDEATSALD ESE++VQ AL+ AS+GRTT
Sbjct: 507 VIGAGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTT 566
Query: 2079 IVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAK-RGVYNDLVQAQLLE------SHD 1921
+ +AHRLSTIRNAS HDELI+K G+Y +V+AQ +E + D
Sbjct: 567 LCIAHRLSTIRNAS--------------THDELISKDDGIYASMVKAQEIERAKEDTTLD 612
Query: 1920 DHEE-----------LPPLAARQLSQELSPLHSYAIQRSTSNDAGVHDDDMERILDELSK 1774
D E+ + R+L Q L+ + Q S V + ++E +E+ +
Sbjct: 613 DEEDEKTHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPEWEIENAREEMIE 672
Query: 1773 EGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYY 1594
EGA +++L +I K P+ + I++ + I+G ++P + + + ++ + G+D+
Sbjct: 673 EGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIK 732
Query: 1593 SHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSA 1414
+ L +L F+ LA ++ GK E +S RLR+ F +++ +++DD H+
Sbjct: 733 ALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNV 792
Query: 1413 TRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXX 1234
L++RL TD+ NV+AA+D RL V+ +V++ + A Y W M L
Sbjct: 793 GSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGLATELLLVVV 852
Query: 1233 XXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSY 1054
Q D + ++R E++ N +TV+AL ++ + + + H+
Sbjct: 853 QSSVAQYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRA 912
Query: 1053 FKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSA 874
R + Q + L+ S ++ +++++ FG +L P + V+ L+M + A
Sbjct: 913 IVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLA 972
Query: 873 AAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMI 694
A+Y P+Y +A +AG++F + + + G KG I V F Y R +++
Sbjct: 973 ASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFAYPNRRRQLV 1032
Query: 693 LNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSN 514
L+G N+ + G+T+ALVGPSGCGKST I L+ER+Y A+ G VKID ++ D+++ HLR N
Sbjct: 1033 LDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDN 1092
Query: 513 LALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERG 334
+ALV QEPTLFN +IREN+ YGL ++ Q ++EKA AN FV P G DT VG G
Sbjct: 1093 IALVGQEPTLFNLTIRENITYGL-ENITQDQVEKAATLANIHTFVMGLPDGYDTSVGASG 1151
Query: 333 AQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHR 154
+LSGGQKQR+AIARAI+R+PK+LLLDEATSALD++SEK+VQ ALD A + VV+AHR
Sbjct: 1152 GRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHR 1211
Query: 153 LSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
LST+ NAD I V +NGK E+GTH+ LL +R +Y+RLV+KQ
Sbjct: 1212 LSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 1252
Score = 261 bits (668), Expect = 7e-68
Identities = 180/583 (30%), Positives = 294/583 (49%), Gaps = 16/583 (2%)
Frame = -1
Query: 1722 DYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFA---MIGE--------DMLYYSH---L 1585
DY + SA+ G P + + +EG A M GE +M ++S +
Sbjct: 42 DYILFSGGLILSAVNGALVPFNSLI----FEGIANALMEGESQYQNGTINMPWFSSEIKM 97
Query: 1584 WALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRL 1405
+ L + +L V L Y + E+ +R K +L ++D+ L
Sbjct: 98 FCLRYFYLGVALFLCSYFANSCLYTLCERRLHCIRKKYLKSVLRQDAKWFDETTIGG--L 155
Query: 1404 SNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXX 1225
+ ++++ +K + D++G ++ V ++ CW++TL +++ P
Sbjct: 156 TQKMSSGIEKIKDGIGDKVGVLVGGVATFISGVSIGFYMCWQLTLVMMITVPLQLGSMYL 215
Query: 1224 XXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKR 1045
A + + A+ N+ A E + +RTV A N + ++ + L + + ++
Sbjct: 216 SAKHLNRATKNEMSAYSNAGGMANEVIAGIRTVMAFNAQPFEINRYAHQLNEARRMGIRK 275
Query: 1044 AIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAY 865
AII L +V+F +G LA V+ + V + + G AA +
Sbjct: 276 AIILAICTAFPLMLMFTCMAVAFWYGATLAAAGAVSSGAVFAVFWAVLIGTRRLGEAAPH 335
Query: 864 LPDYKKAVHAAGLIFHLFTYPATMPFSSSDGK-KNIEKGEIIGENVQFHYDQRPDRMILN 688
L A A IF + + + +SS+GK +G++ + ++F Y RP+ IL
Sbjct: 336 LGAITGARLAIHDIFKVIDHEPEIKCTSSEGKIPEKIQGKLTFDGIEFTYPTRPELKILK 395
Query: 687 GVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLA 508
GV+ +V+PG+T+ALVG SGCGKST I LL RFY+ G +K+D +++ N+ LRS +
Sbjct: 396 GVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRWLRSTIG 455
Query: 507 LVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQ 328
+V QEP +F ++ EN+ G Q ++E+A + ANA F+ + DT++G Q
Sbjct: 456 IVQQEPIIFVATVAENIRMGDVLITDQ-DIEEACKMANAHEFICKLSDRYDTVIGAGAVQ 514
Query: 327 LSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLS 148
LSGGQKQR+AIARAI+R P++LLLDEATSALD++SE++VQ ALD ASE +T+ +AHRLS
Sbjct: 515 LSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCIAHRLS 574
Query: 147 TVVNADSIAVLKNGKVAEQGTHEELLRK-RSIYWRLVQKQGIQ 22
T+ NA TH+EL+ K IY +V+ Q I+
Sbjct: 575 TIRNA--------------STHDELISKDDGIYASMVKAQEIE 603
>gi|72475|pir||DVMS1A multidrug resistance protein 1a - mouse
(fragment)
gi|200330|gb|AAA03243.1| mdr1a protein
Length = 1104
Score = 706 bits (1821), Expect = 0.0
Identities = 412/1101 (37%), Positives = 609/1101 (54%), Gaps = 49/1101 (4%)
Frame = -1
Query: 3186 DNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGV 3007
D++ + E +KI + + F G + F W+L + S + S I + +
Sbjct: 1 DDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKIL 60
Query: 3006 MKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYS 2827
T K+ YA AG++A + L A +TV + GQK E+ERY L+ ++ GI++A+ +
Sbjct: 61 SSFTDKELHAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEAKRLGIKKAITAN 120
Query: 2826 ISRGVTYFFCNSLNTVVLYVGATMIYS--------------------------------- 2746
IS G + + + + G +++ S
Sbjct: 121 ISMGAAFLLIYASYALAFWYGTSLVISKEYSIGQVLTVFFSVLIGAFSVGQASPNIEAFA 180
Query: 2745 ----GTLETAVVVRDDNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFD 2578
E ++ + I+ + GN+ FKN+ FSYP+R + Q+LKG++
Sbjct: 181 NARGAAYEVFKIIDNKPSIDSFSKSGHKPDNIQGNLEFKNIHFSYPSRKEVQILKGLNLK 240
Query: 2577 VQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQE 2398
V++G+ +ALVG SG GKST VQL+ Y+ G + IDG D+ +N++ LR +IGVVSQE
Sbjct: 241 VKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRYLREIIGVVSQE 300
Query: 2397 PVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQK 2218
PVLF TTI ENIR+G +V++ EI A+++ANAYDF+ P T+VGERG +SGGQK
Sbjct: 301 PVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPHQFDTLVGERGAHVSGGQK 360
Query: 2217 QRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNAS 2038
QRIAIAR LVRNPKILLLDEATSALD ESE VVQ AL+ A +GRTTIV+AHRLST+RNA
Sbjct: 361 QRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNAD 420
Query: 2037 KIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLL--------ESHDDHEELPPLAARQL 1882
I G IVE GNHDEL+ ++G+Y LV Q E+ +E+ L
Sbjct: 421 VIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTAGNEIELGNEACKSKDEIDNLDMSSK 480
Query: 1881 SQELSPLHSYAIQRSTSNDAGVHDDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFI 1702
S + + ++S G HD D + E E ++ I+K ++ + +
Sbjct: 481 DSGSSLIRRRSTRKSI---CGPHDQDRKLSTKEALDEDVPPASFWRILKLNSTEWPYFVV 537
Query: 1701 AVFGSAIQGVSYPILAQLIVRTYEGFAMIG--EDMLYYSHLWALSFMFLAVFRPLTLYCQ 1528
+F + I G P + + + F G E S+L++L F+ L + +T + Q
Sbjct: 538 GIFCAIINGGLQPAFSVIFSKVVGVFTNGGPPETQRQNSNLFSLLFLILGIISFITFFLQ 597
Query: 1527 YYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRL 1348
+ FGK E L+ RLR F ML +++DDP ++ L+ RL D++ VK A RL
Sbjct: 598 GFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGATGSRL 657
Query: 1347 GCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENS 1168
+ + + I + +Y W++TL +L P +D E S
Sbjct: 658 AVIFQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGS 717
Query: 1167 NRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVY 988
+ A EA+EN RTV +L E K ++ ++ LQ +++ K+A + G + + F Y
Sbjct: 718 GKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNAMKKAHVFGITFSFTQAMMYFSY 777
Query: 987 SVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKA-VHAAGLIFHLF 811
+ F+FG YL ++ + + LV + A G +++ PDY KA V A+ +I +
Sbjct: 778 AACFRFGAYLVTQQLMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKATVSASHIIRIIE 837
Query: 810 TYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSG 631
P +S+ K N+ +G + V F+Y RP +L G++L+V G+TLALVG SG
Sbjct: 838 KTPEIDSYSTQGLKPNMLEGNVQFSGVVFNYPTRPSIPVLQGLSLEVKKGQTLALVGSSG 897
Query: 630 CGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLY 451
CGKST++ LLERFY + G V +D + ++ +N+ LR+ L +VSQEP LF+CSI EN+ Y
Sbjct: 898 CGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAQLGIVSQEPILFDCSIAENIAY 957
Query: 450 G-LTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRN 274
G +R V E+ +A + AN F+ P +T VG++G QLSGGQKQRIAIARA++R
Sbjct: 958 GDNSRVVSYEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQ 1017
Query: 273 PKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAE 94
P +LLLDEATSALD++SEKVVQ ALD A E + +V+AHRLST+ NAD I V++NGKV E
Sbjct: 1018 PHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGKVKE 1077
Query: 93 QGTHEELLRKRSIYWRLVQKQ 31
GTH++LL ++ IY+ +V Q
Sbjct: 1078 HGTHQQLLAQKGIYFSMVSVQ 1098
>gi|39595964|emb|CAE67467.1| Hypothetical protein CBG12969
[Caenorhabditis briggsae]
Length = 1231
Score = 698 bits (1801), Expect = 0.0
Identities = 431/1219 (35%), Positives = 663/1219 (54%), Gaps = 45/1219 (3%)
Frame = -1
Query: 3636 QSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTI 3457
+S CS +R S+ ++ L LG+ S+ G C + F +++ VL++
Sbjct: 23 ESSSSNSFSYCSLLRY----SNKVDRLLLGLGIFLSISQGCCSSLNAILFRDLTDVLISG 78
Query: 3456 TNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYR 3277
+ N+T D ++++ ++ +FL G F + + + ++
Sbjct: 79 QGSYTNQTFD-------HQQFNNETLNIIHTYFLYGTLLFSLSFVSMCCWHTFCERQIFK 131
Query: 3276 VRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTAL 3097
+R Y S LL++D ++FD +G +ND LER R+ +K+ +IIA++T F G +L
Sbjct: 132 IRVAYFSALLRQDWEWFDQNDSGAAIVRMNDGLERVRDGLGDKLGVIIAYLTHFFCGLSL 191
Query: 3096 AFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCS 2917
AFY + + + I+ + K T K+ Y +A + A + + KTV S
Sbjct: 192 AFYLSVEMTIVTLIITPAFILPIIISRKMISKVTFKELEAYESAATAAGEVISGIKTVVS 251
Query: 2916 LNGQKTEIERYTEELKAGEKYGIRRA------------------------------LMYS 2827
NG++ EI RY++ L +G+ RA L S
Sbjct: 252 FNGEQKEINRYSKFLSKAMYWGLWRASLSSFEGLLGHSSCVFQWQFHSGWWGTRLVLKGS 311
Query: 2826 ISRGVTYFFCNSLNTVVLYVGATM--------IYSGTLETAVVVRDDNVIEKDETDYDVE 2671
I+ G T ++N + +VG + YS + ++ D VI +D ++
Sbjct: 312 ITPGTTLAVFWAVNGAIYFVGQAIPHLTSVSSCYSAAVPVFQII-DRTVILDGTSDKGLK 370
Query: 2670 V-EVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYY 2494
+ +V G + F+NV F YP R VLKGIS GE IALVG SGSGKST L++H+Y
Sbjct: 371 LSKVKGKVKFENVWFKYPARQKVNVLKGISLHANPGENIALVGHSGSGKSTTAALMMHFY 430
Query: 2493 NIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGAL 2314
++ G I ID +++++N+ LR ++G+VSQEP+LF T+E N+R G P++ E+
Sbjct: 431 ELNGGKISIDDTNIDELNLSHLRNIVGIVSQEPLLFADTVENNMRLGAPDLDDNEMEYYC 490
Query: 2313 RKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNE 2134
+ ANA+DF+ P G KT +G G +LSGGQ+QRIAIARTL R P IL+LDEATSALD+E
Sbjct: 491 KLANAHDFIEQLPNGYKTAIGNGGVELSGGQRQRIAIARTLARKPSILILDEATSALDSE 550
Query: 2133 SEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYND 1954
SE +VQ ALENA++GRTTI +AHRL TIRN ++I V G+IVEVG+H EL+ K G Y
Sbjct: 551 SESLVQIALENAAEGRTTITIAHRLGTIRNCNRIYVFDDGKIVEVGSHQELMEKDGHYAK 610
Query: 1953 LVQAQLLESHDDHEELPPLAARQLSQELSPLHSYAIQRSTSNDAGVHDDDMERILDELS- 1777
+VQ+Q +E + E + + +E S + Q+ + A E++L ++S
Sbjct: 611 MVQSQEIEVGNRQESTMEEYSFESRRESCDSKS-SRQKFSKKTARSCSLTSEKLLSDISP 669
Query: 1776 ----KEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAM-IG 1612
+E + S EI++ +P++ L I++ S ++G +YPI + L R + +
Sbjct: 670 LPIGEENEQPSTFLEILRYTKPEWGLLAISILISVLRGFNYPIYSILYGRMFRILSTGTD 729
Query: 1611 EDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYD 1432
E+ S + A+ L ++ + G V E+L+ RLRI F+++L ++D
Sbjct: 730 EEKSSNSGMNAIYLTALGIYALIVTMAAGCLIGYVGERLTKRLRILLFTNILRQDGEYFD 789
Query: 1431 DPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFF 1252
P H+ RL RL+TD+ N++AA+D RL VI A+ I A + M L L+
Sbjct: 790 VPEHAPGRLITRLSTDAPNIRAAIDQRLADVIQGFSAVFCGIAIAFWFSPTMALMGLVNV 849
Query: 1251 PXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQ 1072
++D+ E +R AIEA+E RTV+ L E + ++ +
Sbjct: 850 GVLISLQGFITHVLKKRGEKDSERSEEPSRLAIEAVEQHRTVQYLTREQSFVKKFADGMH 909
Query: 1071 KIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTA 892
IH +R I+Q + LS S F +++ ++FG L P + V+ +L+ ++
Sbjct: 910 PIHIRNLQRGILQSISYALSTSYTSFSFAIGYRFGLLLVDHDLANPFTVFQVIESLNSSS 969
Query: 891 NMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQ 712
+ +Y+P++ +A +AGL+F + Y + S+ GKK +I +NV F Y
Sbjct: 970 PSLLALGSYIPEFVRAQISAGLLFQMLRYEPKI--DSNTGKKTTLDSDISLKNVYFGYQV 1027
Query: 711 RPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINL 532
+MIL LK++ GKT A+VG SGCGKST I LLERFY + G + S N+ D+NL
Sbjct: 1028 SGRKMILKDFTLKIESGKTTAIVGASGCGKSTTIQLLERFYDPIAGRIDFGSTNLRDLNL 1087
Query: 531 NHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDT 352
HLRS +ALV QEPTLFN SIR+N+ YGL S+ + E+ +A + A+A F+ P+G DT
Sbjct: 1088 KHLRSQVALVEQEPTLFNYSIRKNIAYGL-ESIKEGEVIQAAKIAHAHEFITSLPEGYDT 1146
Query: 351 LVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLST 172
+VGE G++LSGGQKQRIAIARAI+RNPK+LLLDEA SALD +SE++VQ AL+ A E +
Sbjct: 1147 IVGEGGSKLSGGQKQRIAIARAIVRNPKILLLDEAMSALDVESERLVQEALEKAKEGRTC 1206
Query: 171 VVVAHRLSTVVNADSIAVL 115
VV+AHRL+T+ A I ++
Sbjct: 1207 VVIAHRLTTIRGALLILIV 1225
Score = 267 bits (683), Expect = 1e-69
Identities = 172/530 (32%), Positives = 276/530 (51%), Gaps = 2/530 (0%)
Frame = -1
Query: 1602 LYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPN 1423
LY + L++LSF+ + + +C+ F ++R+ FS +L ++D +
Sbjct: 105 LYGTLLFSLSFVSMCCWHT---FCERQIF---------KIRVAYFSALLRQDWEWFDQND 152
Query: 1422 HSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXX 1243
A + R+N V+ + D+LG +I + ++ A +MT+ L+ P
Sbjct: 153 SGAAIV--RMNDGLERVRDGLGDKLGVIIAYLTHFFCGLSLAFYLSVEMTIVTLIITPAF 210
Query: 1242 XXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIH 1063
++ A+E++ A E + ++TV + N E K ++ S+ L K
Sbjct: 211 ILPIIISRKMISKVTFKELEAYESAATAAGEVISGIKTVVSFNGEQKEINRYSKFLSKAM 270
Query: 1062 KSYFKRAIIQGAANGLSLSCFLFVYSV-SFKFGTYLALRKEVAPMDTYLVLMTLSMTANM 886
RA + L S +F + S +GT L L+ + P T V ++
Sbjct: 271 YWGLWRASLSSFEGLLGHSSCVFQWQFHSGWWGTRLVLKGSITPGTTLAVFWAVNGAIYF 330
Query: 885 AGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIE-KGEIIGENVQFHYDQR 709
G A +L AA +F + + +S G K + KG++ ENV F Y R
Sbjct: 331 VGQAIPHLTSVSSCYSAAVPVFQIIDRTVILDGTSDKGLKLSKVKGKVKFENVWFKYPAR 390
Query: 708 PDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLN 529
+L G++L +PG+ +ALVG SG GKST +L+ FY G++ ID N++++NL+
Sbjct: 391 QKVNVLKGISLHANPGENIALVGHSGSGKSTTAALMMHFYELNGGKISIDDTNIDELNLS 450
Query: 528 HLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTL 349
HLR+ + +VSQEP LF ++ N+ G + E+E + ANA +F+ Q P G T
Sbjct: 451 HLRNIVGIVSQEPLLFADTVENNMRLGAP-DLDDNEMEYYCKLANAHDFIEQLPNGYKTA 509
Query: 348 VGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTV 169
+G G +LSGGQ+QRIAIAR + R P +L+LDEATSALDS+SE +VQ AL+ A+E +T+
Sbjct: 510 IGNGGVELSGGQRQRIAIARTLARKPSILILDEATSALDSESESLVQIALENAAEGRTTI 569
Query: 168 VVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQV 19
+AHRL T+ N + I V +GK+ E G+H+EL+ K Y ++VQ Q I+V
Sbjct: 570 TIAHRLGTIRNCNRIYVFDDGKIVEVGSHQELMEKDGHYAKMVQSQEIEV 619
Score = 258 bits (658), Expect = 1e-66
Identities = 180/581 (30%), Positives = 303/581 (51%), Gaps = 38/581 (6%)
Frame = -1
Query: 3651 TPLLPQSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQ 3472
+PL + ++PS +R E L + +L S++ GF P S +G + +
Sbjct: 668 SPLPIGEENEQPSTFLEILRYTKP-----EWGLLAISILISVLRGFNYPIYSILYGRMFR 722
Query: 3471 VLVTITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGD 3292
+L T T D EK+ GMN + + G I ++ YVG+
Sbjct: 723 ILSTGT-----------DEEKSSNS---GMNAI--YLTALGIYALIVTMAAGCLIGYVGE 766
Query: 3291 NTTYRVRKQYISRLLKKDAQYFD--SVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTD 3118
T R+R + +L++D +YFD + G L T L+ + R ++++A +I +
Sbjct: 767 RLTKRLRILLFTNILRQDGEYFDVPEHAPGRLITRLSTDAPNIRAAIDQRLADVIQGFSA 826
Query: 3117 FTLGTALAFYTDWRLASYGIF-FSLGIAFSGFINSAGVMKTTGKQNTHYANAGS-IAFQT 2944
G A+AF+ +A G+ + I+ GFI V+K G++++ + S +A +
Sbjct: 827 VFCGIAIAFWFSPTMALMGLVNVGVLISLQGFITH--VLKKRGEKDSERSEEPSRLAIEA 884
Query: 2943 LGAYKTVCSLNGQKTEIERYTEELK----AGEKYGIRRALMYSISRGVTYF--------- 2803
+ ++TV L +++ ++++ + + + GI +++ Y++S T F
Sbjct: 885 VEQHRTVQYLTREQSFVKKFADGMHPIHIRNLQRGILQSISYALSTSYTSFSFAIGYRFG 944
Query: 2802 -------------------FCNSLNTVVLYVGATM--IYSGTLETAVVVRDDNVIEKDET 2686
NS + +L +G+ + + ++ + K ++
Sbjct: 945 LLLVDHDLANPFTVFQVIESLNSSSPSLLALGSYIPEFVRAQISAGLLFQMLRYEPKIDS 1004
Query: 2685 DYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLL 2506
+ + ++ +IS KNV F Y +LK + +++G+ A+VGASG GKST +QLL
Sbjct: 1005 NTGKKTTLDSDISLKNVYFGYQVSGRKMILKDFTLKIESGKTTAIVGASGCGKSTTIQLL 1064
Query: 2505 LHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEI 2326
+Y+ +G I +L D+N+K LR + +V QEP LFN +I +NI +G ++ E+
Sbjct: 1065 ERFYDPIAGRIDFGSTNLRDLNLKHLRSQVALVEQEPTLFNYSIRKNIAYGLESIKEGEV 1124
Query: 2325 YGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSA 2146
A + A+A++F+ S P+G TIVGE G++LSGGQKQRIAIAR +VRNPKILLLDEA SA
Sbjct: 1125 IQAAKIAHAHEFITSLPEGYDTIVGEGGSKLSGGQKQRIAIARAIVRNPKILLLDEAMSA 1184
Query: 2145 LDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVM 2023
LD ESE++VQ+ALE A +GRT +V+AHRL+TIR A I+++
Sbjct: 1185 LDVESERLVQEALEKAKEGRTCVVIAHRLTTIRGALLILIV 1225
>gi|31213429|ref|XP_315658.1| ENSANGP00000021663 [Anopheles gambiae]
gi|21299609|gb|EAA11754.1| ENSANGP00000021663 [Anopheles gambiae str.
PEST]
Length = 1243
Score = 697 bits (1800), Expect = 0.0
Identities = 442/1256 (35%), Positives = 657/1256 (52%), Gaps = 69/1256 (5%)
Frame = -1
Query: 3585 FKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLE-- 3412
F+ ++ E L+GVL + M P+ +GE + +LV T I T D A L
Sbjct: 1 FRFATWGEVCATLMGVLLASMASLGLPYGVILYGEFTTLLVDRTIGIGKST-DTAILSIF 59
Query: 3411 -------KAYEEYERGMNQVVFHFFLCGCA-----YFIFASLQHAIMKYVGDNTTYRVRK 3268
A E+ F G FIFA+L ++ R+R+
Sbjct: 60 GGGRVLVNATEQENAAAIMEDAKAFGLGVVAVTILQFIFATLSVDVINRSAQKQISRIRQ 119
Query: 3267 QYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFY 3088
++ +L++D ++D S + + D+L++ +E EK+++ V F + +F+
Sbjct: 120 LFLKAVLRQDMTWYDLNSDDSFAVRITDDLDKLKEGIGEKLSIFTYLVMSFVISVIFSFF 179
Query: 3087 TDWRLA----SYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVC 2920
W+L S L AF + S T K+ Y++AG++A + LG+ +TV
Sbjct: 180 YGWKLTLVILSCAPIIILATAFVAKMQST----LTEKELKSYSSAGAVAEEVLGSIRTVV 235
Query: 2919 SLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYS-- 2746
+ G+K E +RY E L E G R+ L I G+ +F + + G ++I
Sbjct: 236 AFGGEKKEADRYRERLAGAELNGRRKGLFSGIGGGIMWFIIYCCYALAFWYGISLILEDR 295
Query: 2745 ----------------------------------------GTLETAVVVRDDNVIEKDET 2686
G+ T V D +
Sbjct: 296 DKDLKDYTPAVLIIVLFGVLAGAQNLGLSSPHLEAFSTAKGSAATIFSVIDRIPVIDSLG 355
Query: 2685 DYDVEV-EVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQL 2509
D + + GNI F NV F YP R D QVL+G++ +++ G+ +ALVG SG GKST +QL
Sbjct: 356 DAGLRPGSMQGNIKFSNVFFRYPARNDVQVLQGLNLEIKTGQTVALVGPSGCGKSTCLQL 415
Query: 2508 LLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPE 2329
+ Y+ SG++ IDG ++++NI LR IG+V QEPVLF TTI ENIR+GNP+ S E
Sbjct: 416 IQRLYDPLSGSVTIDGTKVSELNIGWLRSFIGLVGQEPVLFATTIAENIRYGNPDASQSE 475
Query: 2328 IYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATS 2149
I A + AN + F+ P G T++GERG QLSGGQKQRIAIAR LVRNPKILLLDEATS
Sbjct: 476 IERAAKIANCHSFITKLPNGYATMIGERGAQLSGGQKQRIAIARALVRNPKILLLDEATS 535
Query: 2148 ALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKR 1969
ALD SE+ VQ ALE AS+GRTT+VV+HRLSTI NA KI+ + KG ++E G H+EL+A R
Sbjct: 536 ALDPNSEKRVQDALERASKGRTTLVVSHRLSTITNADKIVYIDKGLVMEQGTHEELMAAR 595
Query: 1968 GVYNDLVQAQLLESHDDHEELPPLAARQLSQELSPLHSYAIQRSTSNDAGVHDDDMERIL 1789
G+Y DLV A + D +E P+A LS + A +D+G D+
Sbjct: 596 GLYYDLVVASGSQKTVDDDESVPMAPSALSMRQESVDDGAEASDDESDSGKSDEK----- 650
Query: 1788 DELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAM--- 1618
+E +E +L ++K P++ ++ + + G S+P A L Y ++
Sbjct: 651 NEEEQEEVYHVSLMRLLKLNAPEWHYILFGCAAAIVVGASFPAFAVLFGEMYGILSVADP 710
Query: 1617 --IGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPC 1444
+ E+ +YS L F+ L + + + Q Y F +L++RLR KSF ++S
Sbjct: 711 EYVKEESNFYSFL----FLVLGLITGVGTFFQTYLFNIAGVRLTSRLRQKSFKAIVSQDM 766
Query: 1443 AFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEV 1264
A++D+ ++ L RL+ D ++V+ A R+G ++ I I + + Y W +TL
Sbjct: 767 AWFDESRNAVGALCARLSGDCASVQGATGTRIGSLLQAASTICIGVGISFFYSWNLTLVS 826
Query: 1263 LMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLIS 1084
++ P + ++ + E + + A+EA+ N+RTV +L E ++
Sbjct: 827 IIAIPVTLASITLESRYSQTSSLKEKQSQEGATKLAVEAISNIRTVASLGQEKHVLQRYG 886
Query: 1083 EHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTL 904
E KI + ++ ++G L Y ++ +G L KE+ D V L
Sbjct: 887 EETVKIDDACRRKTRLRGTVFALGQVMPFAGYGLALFYGGKLVSEKELEYKDVIKVSEAL 946
Query: 903 SMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATM--PFSSSDGKKNIEKGEIIGENV 730
A M G A AY P+ A+ +AG + L M P +S +G+I +V
Sbjct: 947 IFGAWMLGQALAYAPNVNSAILSAGRLMKLLDRTPRMHNPSTSYHSLSQRTEGDIKFTDV 1006
Query: 729 QFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSEN 550
+F Y RP +L G+NL + G+T+ALVGPSGCGKST I LL R+Y G+V ID
Sbjct: 1007 EFRYPTRPTVPVLQGLNLDIGKGQTVALVGPSGCGKSTCIQLLLRYYDPDSGKVDIDGTT 1066
Query: 549 VEDINLNHLRSNLALVSQEPTLFNCSIRENLLYG-LTRSVPQLELEKALQTANAFNFVFQ 373
+ +LN +R+ + LVSQEP LF+ +I EN+ YG TR + E+ +A + AN F+
Sbjct: 1067 TTEFSLNRIRAQMGLVSQEPILFDRTIAENIAYGDNTREIAMPEIMEAAKMANIHEFIVN 1126
Query: 372 FPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDT 193
P+G DT +G +GAQLSGGQKQRIAIARA++RNP+VLLLDEATSALD+ SEK+VQNALD
Sbjct: 1127 LPKGYDTSLGSKGAQLSGGQKQRIAIARALVRNPRVLLLDEATSALDNQSEKIVQNALDH 1186
Query: 192 ASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGI 25
A + +++AHRL+T+ NA+ I V++NG V E GTH+EL+ K IY +L Q Q +
Sbjct: 1187 ARTGRTCIIIAHRLTTIQNANLICVIQNGVVVEAGTHDELMAKSRIYAKLYQMQQV 1242
Score = 303 bits (776), Expect = 2e-80
Identities = 184/506 (36%), Positives = 271/506 (53%), Gaps = 10/506 (1%)
Frame = -1
Query: 1491 TRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISI 1312
+R+R +L +YD +S + R+ D +K + ++L V++ I
Sbjct: 115 SRIRQLFLKAVLRQDMTWYD--LNSDDSFAVRITDDLDKLKEGIGEKLSIFTYLVMSFVI 172
Query: 1311 AITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVR 1132
++ + Y WK+TL +L P +++ ++ ++ A E L ++R
Sbjct: 173 SVIFSFFYGWKLTLVILSCAPIIILATAFVAKMQSTLTEKELKSYSSAGAVAEEVLGSIR 232
Query: 1131 TVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLAL 952
TV A E K E L + ++ + G G+ Y+++F +G L L
Sbjct: 233 TVVAFGGEKKEADRYRERLAGAELNGRRKGLFSGIGGGIMWFIIYCCYALAFWYGISLIL 292
Query: 951 R------KEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMP 790
K+ P +VL + A G ++ +L + A +A IF + +P
Sbjct: 293 EDRDKDLKDYTPAVLIIVLFGVLAGAQNLGLSSPHLEAFSTAKGSAATIFSVID---RIP 349
Query: 789 FSSSDGKKNIEKGEIIGE----NVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGK 622
S G + G + G NV F Y R D +L G+NL++ G+T+ALVGPSGCGK
Sbjct: 350 VIDSLGDAGLRPGSMQGNIKFSNVFFRYPARNDVQVLQGLNLEIKTGQTVALVGPSGCGK 409
Query: 621 STIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLT 442
ST + L++R Y + G V ID V ++N+ LRS + LV QEP LF +I EN+ YG
Sbjct: 410 STCLQLIQRLYDPLSGSVTIDGTKVSELNIGWLRSFIGLVGQEPVLFATTIAENIRYG-N 468
Query: 441 RSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVL 262
Q E+E+A + AN +F+ + P G T++GERGAQLSGGQKQRIAIARA++RNPK+L
Sbjct: 469 PDASQSEIERAAKIANCHSFITKLPNGYATMIGERGAQLSGGQKQRIAIARALVRNPKIL 528
Query: 261 LLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTH 82
LLDEATSALD +SEK VQ+AL+ AS+ +T+VV+HRLST+ NAD I + G V EQGTH
Sbjct: 529 LLDEATSALDPNSEKRVQDALERASKGRTTLVVSHRLSTITNADKIVYIDKGLVMEQGTH 588
Query: 81 EELLRKRSIYWRLVQKQGIQVETPSD 4
EEL+ R +Y+ LV G Q D
Sbjct: 589 EELMAARGLYYDLVVASGSQKTVDDD 614
>gi|39587988|emb|CAE57219.1| Hypothetical protein CBG00079
[Caenorhabditis briggsae]
Length = 1327
Score = 695 bits (1794), Expect = 0.0
Identities = 435/1259 (34%), Positives = 692/1259 (54%), Gaps = 69/1259 (5%)
Frame = -1
Query: 3588 VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEK 3409
+F+ F+ L +G + ++++G QP M+ G V+ L+
Sbjct: 93 LFRYGKRFDYLLLFIGTICAIISGVSQPIMALVSGRVTNALLVYP--------------P 138
Query: 3408 AYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQY 3229
+++ N+ V+ F G I +Q+ ++ ++R +++ +L+++A +
Sbjct: 139 TSKQFRNKANENVYIFLGIGIFISITNWIQYMCFQHCCSRVMAQMRHRFVYSVLRQNAGW 198
Query: 3228 FDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFS 3049
FD +G ++T LND++ER RE +K+ +++ +A+ +WRLAS + +
Sbjct: 199 FDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVA 258
Query: 3048 LGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELK 2869
+ + + TT K+ AGSIA ++L +TV + NGQ+ + RY EL+
Sbjct: 259 PVCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYQTELE 318
Query: 2868 AGEKYGIRRALMYSISRGVTYFFC--NSLNTVVLYVGATMIYSGTL----ETAVVVRD-- 2713
G ++ + + G+ +F C + L T +LY GA ++ G + + +VV
Sbjct: 319 KGRRFAVWKGFWSGFFGGL-FFLCLFSFLGTGMLY-GAYLLKVGIIGSPGDVFIVVMSML 376
Query: 2712 ------------------------------DNVIEKDETDYDVE--VEVNGNISFKNVKF 2629
D V + D + V G + F+NV F
Sbjct: 377 LGAYFLGLISPHMMVLLNARVSAATIYQTIDRVPKIDPYSKAGKRLPNVVGRVKFENVHF 436
Query: 2628 SYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLN 2449
YP+R +A++L G++ V+ G +ALVG SG GKST V LL Y ++GN+ IDG D+
Sbjct: 437 RYPSRKEAKILNGLNLTVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVR 496
Query: 2448 DMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKG 2269
++NI LR V+G+V QEP+LFN TI N+ GNP + ++ + ANA+DF+ PKG
Sbjct: 497 ELNIDWLRNVVGIVQQEPILFNDTIHNNLLIGNPGATREKMIEVCKMANAHDFIEKMPKG 556
Query: 2268 IKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQG 2089
T++G+ G QLSGGQKQR+AIARTL+R+PKILLLDEATSALD +SE VVQ AL NA++G
Sbjct: 557 YDTLIGDGGVQLSGGQKQRVAIARTLIRDPKILLLDEATSALDAQSESVVQSALNNAAKG 616
Query: 2088 RTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLL----ESHD 1921
RTTI++AHRLSTIR A KI+ +KG IVE GNH+EL+ G Y DLV+AQ E+ +
Sbjct: 617 RTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVHLGGRYFDLVKAQQFKADPEATE 676
Query: 1920 DHEELP------PLAARQLSQELSPLHSYAIQRSTS-NDA-----------GVHDDDMER 1795
+ EE ++R+ S + S A QR S ND+ +D
Sbjct: 677 EFEEEEIDLDDNSRSSRRSSMTSARSGSEAFQRGNSLNDSFSGSRRSARADAENDAFAAH 736
Query: 1794 ILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMI 1615
+ ++++G + +I K + +Y ++F+ + I+G+ P LA + +EGF +
Sbjct: 737 EAEVMAQDGQITAGYLDIFKNAKGNYIYMFLGTVFALIRGLELPALALIFGWVFEGFTFV 796
Query: 1614 --GEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCA 1441
G M++ + ++F + V ++ F VSE LS R R++SF ++L +
Sbjct: 797 PYGGRMMHRMAMAVIAFASVGVGVWISQVASSVLFAIVSENLSLRFRVQSFRNLLYQDAS 856
Query: 1440 FYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKM----- 1276
++D+P H+ +L RL +D+ N+KA VD R+ VI + AI I A +YCW++
Sbjct: 857 YFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVIYALAAIIANIVIAFIYCWQVAILGT 916
Query: 1275 TLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIM 1096
+L +L+ F + + I + + RTAIE +ENV+T++ L +
Sbjct: 917 SLILLLAF------VMIGLAYKISLMNIEQIKNDEAGRTAIEIIENVKTIQLLTRCELFF 970
Query: 1095 SLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLV 916
++ +S K+ +I+ ++ S F+ ++ G + + + T+
Sbjct: 971 DHYQTSSKQQKRSELKKGMIEAINYSITQSFMYFMMCFTYAVGIRVIYDGDKSSDVTFKG 1030
Query: 915 LMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGE 736
++++ + A ++A Y P++ KA AAGL+F++ Y +G + +G I+ E
Sbjct: 1031 IISMMLGAVAVMNSAQYFPEFVKAKTAAGLLFNII-YRKPRTGDLMEGDRPEIRGNILFE 1089
Query: 735 NVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDS 556
NV+F Y QRP + I+ G+ G+T+ALVGPSG GKST I +LERFY G ++ID
Sbjct: 1090 NVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGVLRIDG 1149
Query: 555 ENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVF 376
+++ +++L HLR+ +ALV QEP LF SIREN+ GL + VP ++ KAL+ ANA F+
Sbjct: 1150 QDIRNLSLYHLRTQMALVGQEPRLFAGSIRENVCLGL-KDVPLEKINKALELANANRFLA 1208
Query: 375 QFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALD 196
P G+DT VGE+G QLSGGQKQRIAIARA++R+PK+LLLDEATSALDS+SE+ VQ ALD
Sbjct: 1209 NLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALD 1268
Query: 195 TASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQV 19
A E + + +AHRLS++ N+D I + GKV E G H +L++K+ Y++L++KQ + V
Sbjct: 1269 RAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHAQLMQKKGRYYKLIKKQDLAV 1327
Score = 303 bits (776), Expect = 2e-80
Identities = 189/576 (32%), Positives = 300/576 (51%), Gaps = 5/576 (0%)
Frame = -1
Query: 1728 RPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYYSHLW---ALSFMFLA 1558
R DY LFI + I GVS PI+A + R + + + F+ +
Sbjct: 99 RFDYLLLFIGTICAIISGVSQPIMALVSGRVTNALLVYPPTSKQFRNKANENVYIFLGIG 158
Query: 1557 VFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSS 1378
+F +T + QY F ++ ++R + +L ++D NHS T ++ +LN
Sbjct: 159 IFISITNWIQYMCFQHCCSRVMAQMRHRFVYSVLRQNAGWFDK-NHSGT-ITTKLNDSME 216
Query: 1377 NVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAI 1198
++ + D+LG ++ + AI A +Y W++ +L P
Sbjct: 217 RIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPVCCICMSLLARQMTSTT 276
Query: 1197 QEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANG 1018
++ I + A E+L VRTV+A N +++++ L+K + + G G
Sbjct: 277 IKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYQTELEKGRRFAVWKGFWSGFFGG 336
Query: 1017 LSLSCFLFVYSVSFKFGTYLALRKEV-APMDTYLVLMTLSMTANMAGSAAAYLPDYKKAV 841
L C +G YL + +P D ++V+M++ + A G + ++ A
Sbjct: 337 LFFLCLFSFLGTGMLYGAYLLKVGIIGSPGDVFIVVMSMLLGAYFLGLISPHMMVLLNAR 396
Query: 840 HAAGLIFHLFT-YPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDP 664
+A I+ P P+S + + G + ENV F Y R + ILNG+NL V+P
Sbjct: 397 VSAATIYQTIDRVPKIDPYSKAGKRLPNVVGRVKFENVHFRYPSRKEAKILNGLNLTVEP 456
Query: 663 GKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTL 484
G ++ALVG SGCGKST + LL R Y G V ID +V ++N++ LR+ + +V QEP L
Sbjct: 457 GTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIDWLRNVVGIVQQEPIL 516
Query: 483 FNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQR 304
FN +I NLL G + + +E + ANA +F+ + P+G DTL+G+ G QLSGGQKQR
Sbjct: 517 FNDTIHNNLLIGNPGATREKMIE-VCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQR 575
Query: 303 IAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSI 124
+AIAR ++R+PK+LLLDEATSALD+ SE VVQ+AL+ A++ +T+++AHRLST+ AD I
Sbjct: 576 VAIARTLIRDPKILLLDEATSALDAQSESVVQSALNNAAKGRTTIMIAHRLSTIREADKI 635
Query: 123 AVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQVE 16
+ G + E G HEEL+ Y+ LV+ Q + +
Sbjct: 636 VFFEKGVIVEAGNHEELVHLGGRYFDLVKAQQFKAD 671
>gi|40644167|emb|CAC86593.1| sister of P-glycoprotein [Platichthys
flesus]
gi|40644169|emb|CAC86594.1| sister of P-glycoprotein [Platichthys
flesus]
Length = 1356
Score = 695 bits (1793), Expect = 0.0
Identities = 449/1326 (33%), Positives = 688/1326 (51%), Gaps = 114/1326 (8%)
Frame = -1
Query: 3675 EENSNNFSTPLLPQSDEK------KPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGF 3514
EE ++++ T Q DEK +P+ F ++ F+ S+C E + ++G + +++ G
Sbjct: 26 EEPADSYMTMTSSQKDEKAQGNAEQPAIRVGFFQL-FRFSTCREVVMMVIGSVCAVLHGS 84
Query: 3513 CQPFMSYTFGEVSQVLVTITNAIN----------NKTID-PADLEKAYEEYERGMNQV-- 3373
QP M FG ++ + +N N TI +D A + + +N
Sbjct: 85 AQPLMLLVFGLLTDTFIEYDIELNELRDVRKECVNNTIQWKSDYTAALNQSDWSLNSTWE 144
Query: 3372 --------------------VFHFFLCGCAY--FIFASLQHAIMKYVGDNTTYRVRKQYI 3259
F + G A+ F+ LQ ++ VRK Y
Sbjct: 145 VLVPLKNLTCGVLDIEYEMTKFALYYVGIAFAVFLLGYLQISLWVQAAARQVQIVRKMYF 204
Query: 3258 SRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDW 3079
S++++ + +FD S G L+T ++D++ + + +++A+ + T F G + F W
Sbjct: 205 SKVMRMEIGWFDCTSVGELNTRMSDDINKINDAIADQVAIFLQRFTTFVCGFCIGFVKGW 264
Query: 3078 RLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKT 2899
+L + S I + V K TG++ YA AG++A + L + +TV + G+
Sbjct: 265 KLTLVIVAASPLIGIGAGFMALFVAKLTGRELQAYAKAGAVADEVLSSIRTVSAFGGELK 324
Query: 2898 EIERYTEELKAGEKYGIRRALMYSISRGVTY---FFCNSL-----NTVVL----YVGATM 2755
E++RY L + +++GIR+ ++ G + F C +L + +VL Y T+
Sbjct: 325 EVQRYDRNLISAQRWGIRKGMIMGFFTGYMWLIIFLCYALAFWYGSGLVLDTAEYTPGTL 384
Query: 2754 IY---------------SGTLETAVVVRDDNVIEKDETDYDVEVE-----------VNGN 2653
+ S LE R I + D + E++ V G+
Sbjct: 385 LQVFFGVLIAAMNLGQASPCLEAFAAGRGAATIIFETIDREPEIDCLSEAGYKLDRVKGD 444
Query: 2652 ISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNI 2473
I F NV F YP+RP+ + L +S V++GE A VG SG+GKST +QL +Y+ G +
Sbjct: 445 IEFHNVTFHYPSRPEVKTLDQLSVAVKSGETTAFVGPSGAGKSTAIQLFQRFYDPKEGMV 504
Query: 2472 FIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYD 2293
+DG D+ +NI+ LR +IG+V QEPVLF TTI ENI +G P VS+ +I A ++ANAY
Sbjct: 505 TLDGHDIRGLNIQWLRSLIGIVEQEPVLFATTIAENICYGRPGVSMEDIVAAAKEANAYH 564
Query: 2292 FVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQK 2113
F+ P+ T+VGE G Q+SGGQKQRIAIAR LVRNP+ILLLD ATSALDNESE +VQ+
Sbjct: 565 FIQDLPQKFNTMVGEGGGQMSGGQKQRIAIARALVRNPRILLLDMATSALDNESEAIVQE 624
Query: 2112 ALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLL 1933
AL+ GRTTI +AHRLSTI+NA I+ + G VE G H EL+ ++GVY LV Q
Sbjct: 625 ALDKVRLGRTTISIAHRLSTIKNADVIVGFEHGRAVEKGKHGELLERKGVYFMLVTLQSQ 684
Query: 1932 ESHDDHEELPPLAARQ---LSQELSPLHSYAI-------QRSTSNDAGVHDDDMERILDE 1783
+E+ LA ++ + Q LS SY QRS S + + D ++ E
Sbjct: 685 GDKALNEKARQLAEKEEEPVKQNLSRAGSYRASLRSSIRQRSRSQLSNLIPDSSASMVGE 744
Query: 1782 L-------SKEGAKKSNLRE--------------IVKQCRPDYCFLFIAVFGSAIQGVSY 1666
L S+ K+++ E I+K P++ ++ G+AI G
Sbjct: 745 LGPRTYTFSQPDTSKADIPEEEEEEVVEPAPVARILKYNIPEWPYMLFGSIGAAINGGVN 804
Query: 1665 PILAQLIVRTYEGFAMIGEDMLYYSHLWALS--FMFLAVFRPLTLYCQYYYFGKVSEQLS 1492
P+ + L + F+ + + + + ++ F+ + V T Q Y F K E L+
Sbjct: 805 PVYSLLFSQILATFS-VTDPVAQRKEIDSICMFFVMVGVVSSFTQMLQGYAFSKSGELLT 863
Query: 1491 TRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISI 1312
RLR F ML ++DD +S L+ RL TD+S V+ A ++G ++ ++ I +
Sbjct: 864 RRLRRLGFHAMLGQEIGWFDDHRNSPGALTTRLATDASQVQGATGSQIGMIVNSLTNIGV 923
Query: 1311 AITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVR 1132
A+ + + WK+T+ +L F P ++D A E + R + EAL N+R
Sbjct: 924 AVLMSFYFSWKLTMLILCFLPFIALSGGFQAKMLTGFAKQDKEAMEAAGRISGEALNNIR 983
Query: 1131 TVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLAL 952
T+ L E + + L ++ K+A + GA G + S S++FG YL
Sbjct: 984 TIAGLGKEQSFVDMYEAQLDGPFQAALKKAHVYGACYGFAQCVVFLTNSASYRFGGYLVR 1043
Query: 951 RKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLF-TYPATMPFSSSD 775
++ + + V+ + + G A++Y PDY KA +A F L P +S
Sbjct: 1044 QEGLHFSLVFRVISAIVTSGTALGKASSYTPDYAKAKISAARFFKLLDRVPQISVYSDKG 1103
Query: 774 GKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLER 595
K + +G + + +F Y RPD +LNG+N+ V PG+TLA VG SGCGKST + LLER
Sbjct: 1104 DKWDNFQGNLEFIDCKFTYPTRPDIQVLNGLNVSVRPGQTLAFVGSSGCGKSTSVQLLER 1163
Query: 594 FYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYG-LTRSVPQLEL 418
FY G V ID + +N+ LRS + +VSQEP LF+CSI +N+ YG +R + ++
Sbjct: 1164 FYDPDHGRVLIDGHDSTGVNVPFLRSKIGIVSQEPILFDCSIADNIKYGDNSREISLNDV 1223
Query: 417 EKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSA 238
A + A NFV P+ DT VG +G+QLS GQKQRIAIARAI+R+PK+LLLDEATSA
Sbjct: 1224 MSAAKKAQLHNFVMALPEKYDTNVGAQGSQLSRGQKQRIAIARAIIRDPKILLLDEATSA 1283
Query: 237 LDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRS 58
LD++SEK+VQ ALD A E + +V+AHRLST+ N+D IAV+ G V E+GTH +L+ +
Sbjct: 1284 LDTESEKIVQEALDKAREGRTCIVIAHRLSTIQNSDIIAVMSRGYVIEKGTHNQLMLLKG 1343
Query: 57 IYWRLV 40
Y++LV
Sbjct: 1344 AYYKLV 1349
Score = 268 bits (684), Expect = 9e-70
Identities = 174/531 (32%), Positives = 271/531 (50%), Gaps = 4/531 (0%)
Frame = -1
Query: 1608 DMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDD 1429
D+ Y +AL ++ +A L Y Q + + + + +R FS ++ + ++D
Sbjct: 158 DIEYEMTKFALYYVGIAFAVFLLGYLQISLWVQAAARQVQIVRKMYFSKVMRMEIGWFDC 217
Query: 1428 PNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFP 1249
S L+ R++ D + + A+ D++ + + WK+TL ++ P
Sbjct: 218 T--SVGELNTRMSDDINKINDAIADQVAIFLQRFTTFVCGFCIGFVKGWKLTLVIVAASP 275
Query: 1248 XXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQK 1069
+ A+ + A E L ++RTV A E K + +L
Sbjct: 276 LIGIGAGFMALFVAKLTGRELQAYAKAGAVADEVLSSIRTVSAFGGELKEVQRYDRNLIS 335
Query: 1068 IHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLAL-RKEVAPMDTYLVLMTLSMTA 892
+ ++ +I G G Y+++F +G+ L L E P V + + A
Sbjct: 336 AQRWGIRKGMIMGFFTGYMWLIIFLCYALAFWYGSGLVLDTAEYTPGTLLQVFFGVLIAA 395
Query: 891 NMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKK-NIEKGEIIGENVQFHYD 715
G A+ L + AA +IF + S G K + KG+I NV FHY
Sbjct: 396 MNLGQASPCLEAFAAGRGAATIIFETIDREPEIDCLSEAGYKLDRVKGDIEFHNVTFHYP 455
Query: 714 QRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDIN 535
RP+ L+ +++ V G+T A VGPSG GKST I L +RFY +G V +D ++ +N
Sbjct: 456 SRPEVKTLDQLSVAVKSGETTAFVGPSGAGKSTAIQLFQRFYDPKEGMVTLDGHDIRGLN 515
Query: 534 LNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLD 355
+ LRS + +V QEP LF +I EN+ YG V ++ A + ANA++F+ PQ +
Sbjct: 516 IQWLRSLIGIVEQEPVLFATTIAENICYGRP-GVSMEDIVAAAKEANAYHFIQDLPQKFN 574
Query: 354 TLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLS 175
T+VGE G Q+SGGQKQRIAIARA++RNP++LLLD ATSALD++SE +VQ ALD +
Sbjct: 575 TMVGEGGGQMSGGQKQRIAIARALVRNPRILLLDMATSALDNESEAIVQEALDKVRLGRT 634
Query: 174 TVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLV--QKQG 28
T+ +AHRLST+ NAD I ++G+ E+G H ELL ++ +Y+ LV Q QG
Sbjct: 635 TISIAHRLSTIKNADVIVGFEHGRAVEKGKHGELLERKGVYFMLVTLQSQG 685
>gi|17567265|ref|NP_510126.1| P-GlycoProtein related (pgp-12)
[Caenorhabditis elegans]
gi|7499663|pir||T21266 hypothetical protein F22E10.1 - Caenorhabditis
elegans
gi|3876291|emb|CAA91799.1| Hypothetical protein F22E10.1
[Caenorhabditis elegans]
Length = 1318
Score = 695 bits (1793), Expect = 0.0
Identities = 426/1257 (33%), Positives = 674/1257 (52%), Gaps = 69/1257 (5%)
Frame = -1
Query: 3588 VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEK 3409
+F+ + + L G+ S ++G QP + G ++ L+ I+N T D
Sbjct: 81 LFRYAERTDYALLCFGIFLSFISGIAQPGLGIIAGNITNSLL-----IHNATSD------ 129
Query: 3408 AYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQY 3229
+ Y+ M V + F G I +Q+ +Y T ++++ YI +L+++A +
Sbjct: 130 --DFYDSAMTNV-WLFGGIGIIVLIVNFVQYMCFQYCCIRITSKMKQHYIQSILRQNAGW 186
Query: 3228 FDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFS 3049
FD +G L+T L+DN+ER E +K+ ++I + F G ++F+ +WRLA +
Sbjct: 187 FDKNHSGTLTTKLHDNMERINEGIGDKLGVLIRGMVMFVAGIVISFFYEWRLALMMMGIG 246
Query: 3048 LGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELK 2869
+ S + T K+ AGSIA ++L +TV + NGQ+ +E+YT EL
Sbjct: 247 PLCCVCMSLMSRSMSSFTSKELAGVGKAGSIAEESLMGVRTVQAFNGQEEMVEKYTVELG 306
Query: 2868 AGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYSGTLETA------------- 2728
G+ + I++ L + G+ F S +Y G ++ +ET
Sbjct: 307 KGKSFAIQKGLWGGVFGGIFLLFLFSYFGGGIYYGGQLLRWKIIETPGDVFIVVISMLIG 366
Query: 2727 ----------------VVVRDDNVIEKDETDYDVEV---------EVNGNISFKNVKFSY 2623
V + E + D++V V G + F+ V F Y
Sbjct: 367 AYFLGLISPHLMVLLNARVAAATIYEIIDRTPDIDVYSTEGQKMTNVVGKVVFEEVHFRY 426
Query: 2622 PTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDM 2443
PTR +VL G++ V+ G +ALVG SG GKST V LL Y + G + IDG D+ +
Sbjct: 427 PTRKKVKVLNGLNLTVKPGTSVALVGHSGCGKSTSVGLLTRLYEPEGGKVMIDGQDVRSL 486
Query: 2442 NIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIK 2263
NI LR+ +G+V QEP+LFN TI N+ GNP+ + ++ + ANA+DF+ P G +
Sbjct: 487 NIDWLRKTVGIVQQEPILFNDTIHNNLLIGNPSATREDMIRVCKMANAHDFIQKMPNGYE 546
Query: 2262 TIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRT 2083
T++G+ QLSGGQKQR+AIARTL+R+PK+LLLDEATSALD +SE VVQ AL NA++GRT
Sbjct: 547 TMIGDGSVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESVVQSALNNAAKGRT 606
Query: 2082 TIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLESHDD----- 1918
TI++AHRLSTIR A KI+ + G IVE GNH+EL+A G Y LV+AQ + DD
Sbjct: 607 TIMIAHRLSTIREADKIVFFENGVIVESGNHEELVALGGRYAKLVEAQKFKESDDIEDNG 666
Query: 1917 --HEELPPLAAR--QLSQELSPLH-------------SYA-----IQRSTSNDAGVHDDD 1804
HEE R +LS H YA T+ + ++D
Sbjct: 667 DEHEEETSTVGRHDRLSSRQVSFHKSCESLASADLEIGYASTFNTFTLKTAQEEIENEDF 726
Query: 1803 MERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGF 1624
E + + ++G S +I K + +Y +L + F + ++G +LA + + F
Sbjct: 727 AEEVQRVMEEDGVINSGYLDIFKNAQGNYLYLSVGTFFAILRGSELALLANMFGFVFAAF 786
Query: 1623 AMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPC 1444
++M+ L + ++ L +F +T F V+E L + R++SF ++L
Sbjct: 787 KEPEDEMVKALGLIFILYVALGLFVFITQVISGTLFTIVAENLGLKFRVQSFKNLLYQDA 846
Query: 1443 AFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKM---- 1276
+F+D+P H+ +L RL +D+ NVKA VD R+ VI ++ +I+I + T ++CW++
Sbjct: 847 SFFDNPAHAPGKLITRLASDAPNVKAVVDTRMLQVIYSITSITINLITGYIFCWRIAIAG 906
Query: 1275 TLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIM 1096
T+ +++F I++D + + AIE +E+V+T++ L + +
Sbjct: 907 TIMIVLFATMMISMAYKIARENLKQIRKD-----EAGKIAIEIIESVKTIQLLTSTQRFL 961
Query: 1095 SLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLV 916
+ + HKS +++ IQ N +S + F V + GT L V T+
Sbjct: 962 THYKDAQLVQHKSEMRKSYIQSVNNAISQTFMYFAMFVCYGVGTPLMYHGIVEAEPTFRA 1021
Query: 915 LMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGE 736
+ + M + ++ P++ KA AAG++F L Y + +G +G ++ E
Sbjct: 1022 INCMMMGSVAVMHSSHNFPEFVKAKTAAGMLFKLI-YRKSKTGDVMEGNNTEIRGNVLFE 1080
Query: 735 NVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDS 556
+V+F Y QRP + ++ ++ G+T+ALVGPSG GKST I++LERFY G ++ID
Sbjct: 1081 SVKFSYPQRPMQPVMTDLHFSAHSGQTVALVGPSGTGKSTCIAMLERFYDVSGGALRIDG 1140
Query: 555 ENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVF 376
+N++ ++L+HLR+ +ALV QEP LF +I+EN+ +GL + V ++ +AL+ ANA F+
Sbjct: 1141 QNIKSLSLHHLRTQMALVGQEPRLFAGTIKENVCFGL-KDVSVEKVHQALELANASRFLA 1199
Query: 375 QFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALD 196
P G+DT VGE+G QLSGGQKQRIAIARA++R+PK+LLLDEATSALDS+SE+ VQ ALD
Sbjct: 1200 NLPAGIDTEVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALD 1259
Query: 195 TASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGI 25
A E + + +AHRLS++ N+D I + +G V E G H L+ R Y+ L++KQ +
Sbjct: 1260 RAREGRTCITIAHRLSSIQNSDLIVYIDHGMVQEAGNHAHLMSLRGKYYNLIKKQDL 1316
>gi|14030565|gb|AAK52958.1| bile salt export pump [Raja erinacea]
Length = 1348
Score = 692 bits (1786), Expect = 0.0
Identities = 427/1281 (33%), Positives = 663/1281 (51%), Gaps = 98/1281 (7%)
Frame = -1
Query: 3588 VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAI----------NN 3439
+F+ +SC+E L + G + +L+ G QP + FG ++ + + +N
Sbjct: 67 LFRFASCYEVTLMVFGGVCALLHGVAQPAVLLVFGLLTDTFIAYDIELQELKDTRKHCDN 126
Query: 3438 KTIDPADLEKAYEEY-----------ERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGD 3292
TI + + ++ E+ M +++ GC+ + Q
Sbjct: 127 NTIHWVNGSEYLNQHNETMSCGILNIEKEMTMFAYYYVGIGCSVLLLGYFQICFWVTAAA 186
Query: 3291 NTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFT 3112
T ++RK Y ++++ + +FD S G L+T ++D++ + + +++ + I + F
Sbjct: 187 RQTQKIRKAYFRQIMRMEMGWFDCNSVGELNTRMSDDINKINDAIADQVGIFIQRFSTFV 246
Query: 3111 LGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAY 2932
G + F W+L I S I + + V + TG YA AG++A + L +
Sbjct: 247 SGFLMGFVNGWKLTLVIIAVSPLIGLGAALMALSVARLTGLGLKAYAKAGAVADEVLSSI 306
Query: 2931 KTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMI 2752
+TV + +G+K E++RY L +++GIR+ ++ G + + + G+ ++
Sbjct: 307 RTVAAFSGEKKEVDRYDRNLVFAQRWGIRKGMIMGFFTGYVWMIIFCCYALAFWYGSKLV 366
Query: 2751 --------------YSGTLETAV-------------------------VVRDDNVIEKDE 2689
+ G L A+ + R+ + E
Sbjct: 367 IEQNEYTPGGLLQVFLGVLVAAMNLGQASPCLEAFASGRGAAVKIFETIDREPEIDCMSE 426
Query: 2688 TDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQL 2509
Y + +V G+I F NV F+YP+RPD + L +S ++ GE A VG SGSGKST V+L
Sbjct: 427 GGYTLN-KVKGDIEFHNVTFNYPSRPDVKTLDRLSMVIKAGETTAFVGPSGSGKSTAVEL 485
Query: 2508 LLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPE 2329
+ +Y+ G + +DG D+ +NI+ LR +IG+V QEPVLF+TTIEENIR+ ++ +
Sbjct: 486 IQRFYDPKQGMVTLDGHDIRSLNIQWLRSLIGIVEQEPVLFSTTIEENIRYVREGLTKND 545
Query: 2328 IYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATS 2149
I A ++ANAYDF+ P+ T+VGE G Q+SGGQKQRIAIAR LVRNPKILLLD ATS
Sbjct: 546 IVQAAKEANAYDFIMDLPEKFNTLVGEGGGQMSGGQKQRIAIARALVRNPKILLLDMATS 605
Query: 2148 ALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKR 1969
ALDNESE +VQ AL+ GRTTI +AHRLST+RN II + G VE G H EL+ ++
Sbjct: 606 ALDNESEAIVQGALDKVRFGRTTISIAHRLSTVRNVDVIIGFEHGRAVERGRHAELLERK 665
Query: 1968 GVYNDLVQAQLLESHDDHEELPPL-------------------------------AARQL 1882
G+Y LV Q HE+ + + Q+
Sbjct: 666 GIYFTLVTLQTQGEQALHEKARQVNGAIEDGASEKRQLIRRGSSRASVRSTRHQRSRSQV 725
Query: 1881 SQELSPLHS----YAIQRSTSNDAGVHDDDMERILDELSKEGAKKSNLREIVKQCRPDYC 1714
S+ LS L + R+ S G D D+E +E + + + I+K ++
Sbjct: 726 SEVLSDLSGPGDVASAVRTPSISLGDEDKDVEE-----EEESIEPAPVSRILKYNVSEWP 780
Query: 1713 FLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIG-EDMLYYSHLWALSFMFLAVFRPLTL 1537
++ G+A+ G PI A L + F++ E+ + + L F+ + + LT
Sbjct: 781 YMLFGSLGAAVNGGVNPIYALLFSQILGTFSLQNEEEKINQINAICLFFVVVGLVSFLTQ 840
Query: 1536 YCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVD 1357
+ Q Y+F K E L+ RLR F ML ++DD +S L+ RL TD+S V+ A
Sbjct: 841 FLQSYFFAKSGELLTRRLRKLGFQAMLRQEIGWFDDRKNSPGTLTTRLATDASQVQGATG 900
Query: 1356 DRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAF 1177
++G ++ ++ I +++ A + WK+TL +L F P +D A
Sbjct: 901 TQIGMIVNSITNIGVSLIIAFYFSWKLTLVILCFLPFLALTGALQARMLTGFANQDKEAL 960
Query: 1176 ENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFL 997
E + + + EAL N+RT+ L E + L L+ +K+ K+A + G G + S
Sbjct: 961 EAAGQISSEALSNIRTIAGLAKEKMFVQLFEAQLEAPYKAAIKKANVYGLCFGFAQSVIF 1020
Query: 996 FVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFH 817
+ S++FG YL + + + + V+ + + G A++Y PDY KA AA F
Sbjct: 1021 LANAASYRFGGYLVVAENLHFSIVFRVISAIVTSGTALGRASSYTPDYAKAKIAAARFFQ 1080
Query: 816 LFTYPATMPFSSSDGKK-NIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVG 640
L + SS+G+K + +G+I F Y RPD +LNG+++ V PG+TLA VG
Sbjct: 1081 LIDRAPKINIDSSEGEKWSNFRGDIKFVECTFTYPTRPDFQVLNGLSVCVMPGQTLAFVG 1140
Query: 639 PSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIREN 460
SGCGKST + LLERFY G V ID + ++N LRS + +VSQEP LF+ SI EN
Sbjct: 1141 SSGCGKSTSVQLLERFYDPNQGRVIIDGRSTTNVNTAFLRSKIGIVSQEPVLFDSSIEEN 1200
Query: 459 LLYG-LTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAI 283
+ YG +R V E+ A + A +FV P+ T VG +G+QLS GQKQRIAIARAI
Sbjct: 1201 IKYGDNSRQVSMDEVIAAAKKAQLHSFVMSLPEKYGTRVGAQGSQLSRGQKQRIAIARAI 1260
Query: 282 LRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGK 103
+R+PK+LLLDEATSALD++SEK+VQ+ALD A + + +V+AHRLST+ N+D IAV+ G
Sbjct: 1261 VRDPKILLLDEATSALDTESEKIVQDALDEARKGRTCIVIAHRLSTIQNSDIIAVMSRGI 1320
Query: 102 VAEQGTHEELLRKRSIYWRLV 40
+ EQG+H L+ + Y++LV
Sbjct: 1321 IIEQGSHGNLMAAKGAYYKLV 1341
Score = 270 bits (690), Expect = 2e-70
Identities = 170/512 (33%), Positives = 268/512 (52%), Gaps = 7/512 (1%)
Frame = -1
Query: 1536 YCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVD 1357
Y Q ++ + + + ++R F ++ + ++D +S L+ R++ D + + A+
Sbjct: 175 YFQICFWVTAAARQTQKIRKAYFRQIMRMEMGWFDC--NSVGELNTRMSDDINKINDAIA 232
Query: 1356 DRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAF 1177
D++G I + WK+TL ++ P A+
Sbjct: 233 DQVGIFIQRFSTFVSGFLMGFVNGWKLTLVIIAVSPLIGLGAALMALSVARLTGLGLKAY 292
Query: 1176 ENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFL 997
+ A E L ++RTV A + E K + +L + ++ +I G G
Sbjct: 293 AKAGAVADEVLSSIRTVAAFSGEKKEVDRYDRNLVFAQRWGIRKGMIMGFFTGYVWMIIF 352
Query: 996 FVYSVSFKFGTYLALRK-EVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIF 820
Y+++F +G+ L + + E P V + + + A G A+ L + AA IF
Sbjct: 353 CCYALAFWYGSKLVIEQNEYTPGGLLQVFLGVLVAAMNLGQASPCLEAFASGRGAAVKIF 412
Query: 819 HLFTYPATMPFSSSDGKK-NIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALV 643
+ S G N KG+I NV F+Y RPD L+ +++ + G+T A V
Sbjct: 413 ETIDREPEIDCMSEGGYTLNKVKGDIEFHNVTFNYPSRPDVKTLDRLSMVIKAGETTAFV 472
Query: 642 GPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRE 463
GPSG GKST + L++RFY G V +D ++ +N+ LRS + +V QEP LF+ +I E
Sbjct: 473 GPSGSGKSTAVELIQRFYDPKQGMVTLDGHDIRSLNIQWLRSLIGIVEQEPVLFSTTIEE 532
Query: 462 NLLY---GLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIA 292
N+ Y GLT++ ++ +A + ANA++F+ P+ +TLVGE G Q+SGGQKQRIAIA
Sbjct: 533 NIRYVREGLTKN----DIVQAAKEANAYDFIMDLPEKFNTLVGEGGGQMSGGQKQRIAIA 588
Query: 291 RAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLK 112
RA++RNPK+LLLD ATSALD++SE +VQ ALD +T+ +AHRLSTV N D I +
Sbjct: 589 RALVRNPKILLLDMATSALDNESEAIVQGALDKVRFGRTTISIAHRLSTVRNVDVIIGFE 648
Query: 111 NGKVAEQGTHEELLRKRSIYWRLV--QKQGIQ 22
+G+ E+G H ELL ++ IY+ LV Q QG Q
Sbjct: 649 HGRAVERGRHAELLERKGIYFTLVTLQTQGEQ 680
>gi|39587992|emb|CAE57223.1| Hypothetical protein CBG00086
[Caenorhabditis briggsae]
Length = 1316
Score = 691 bits (1782), Expect = 0.0
Identities = 431/1264 (34%), Positives = 678/1264 (53%), Gaps = 76/1264 (6%)
Frame = -1
Query: 3588 VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEK 3409
+F+ + + + L+G+L S ++G QP + G ++ L+ + N + + +D A +
Sbjct: 81 LFRFAERRDHIILLIGILLSFLSGVAQPGLGVIAGGMTNTLI-VYNVTSPQFLDSALMN- 138
Query: 3408 AYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQY 3229
V+ F G I +Q+ + V ++R++YI +L+++A +
Sbjct: 139 ------------VYLFGGIGVVVLIINFIQYMCFQNVCIRIVTKLREEYIKSILRQNAGW 186
Query: 3228 FDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFS 3049
FD +G L+T L+DN+ER E +K+ ++I + F G ++ + +WRLA +
Sbjct: 187 FDKNHSGTLTTKLHDNMERIHEGIGDKLGVLIRGIVMFGTGIVISLFYEWRLALMMMGIG 246
Query: 3048 LGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELK 2869
+ S + T K+ AGSIA ++L +TV + NGQ+ + RYT EL
Sbjct: 247 PLCCICMSLMSRSMSSYTSKELADVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYTAELG 306
Query: 2868 AGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYSGTLETAVVVRDD------- 2710
G+ Y +++ L G+ L + Y G + Y G L ++ +
Sbjct: 307 KGKSYAVKKGLWGGFFGGIF------LLILFTYFGGGIFYGGQLLRWKIIENPGDVFIVV 360
Query: 2709 ---------------------NVIEKDETDYDV-----EVE-----------VNGNISFK 2641
N T Y+V E++ + G + F+
Sbjct: 361 FSMLIGAYFLGLISPHLMVLLNARVAAATIYEVIDRVPEIDAYSNEGQKIDKIVGRVVFE 420
Query: 2640 NVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDG 2461
NV F YPTR A+VL G++ ++ G +ALVG SG GKST V LL Y + G + IDG
Sbjct: 421 NVHFRYPTRKKAKVLNGLNLTIEPGTSVALVGHSGCGKSTSVGLLTRLYEQEDGKVMIDG 480
Query: 2460 MDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCS 2281
++ ++NI LR+V+G+V QEP+LF+ TI N+ GNPN + ++ + ANA++F+
Sbjct: 481 HEVRNLNIDWLRKVVGIVQQEPILFSGTIHNNLLIGNPNATRDDMIRVCKMANAHEFILK 540
Query: 2280 FPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALEN 2101
PKG T++G+ G QLSGGQKQR+AIARTL+R+PK+LLLDEATSALD +SE VVQ AL N
Sbjct: 541 MPKGYDTVIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESVVQSALNN 600
Query: 2100 ASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLESHD 1921
AS+GRTTI++AHRLSTIR A KI+ + G IVE G HDEL+A G Y LV+AQ + D
Sbjct: 601 ASKGRTTIMIAHRLSTIREADKIVFFESGVIVESGTHDELVALGGRYAALVKAQQFKEAD 660
Query: 1920 --DHEELPPLAARQLSQELSPLH------------------SYAIQRSTSNDAGVHDD-- 1807
D + + AR S++ P YA ++ N DD
Sbjct: 661 EVDDDVEEDITARIFSEKQMPSRQVSYHGSCVSLASADLEIGYASAFNSFNLKQAQDDIE 720
Query: 1806 ------DMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLI 1645
+++R+++E +G S +I K + +Y +L + + ++G +LA +
Sbjct: 721 NEDFAEEVQRVMEE---DGVITSGYYDIFKNAKGNYWYLSMGTVFAIMRGSELALLAIMF 777
Query: 1644 VRTYEGFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFS 1465
+E F +M + + + L ++ +T F V+E L + R++SF
Sbjct: 778 GYVFEAFEKPDAEMARELVIIFILYGCLGLYVFITQVLSSTLFTIVAENLGLKFRVQSFK 837
Query: 1464 HMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYC 1285
++L +F+D+P H+ +L RL TD+ NVKA VD R+ VI ++ +I+I + T C
Sbjct: 838 NLLYQDASFFDNPAHAPGKLITRLATDAPNVKAVVDTRMLQVIYSMTSITINLVTGYACC 897
Query: 1284 WKM----TLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRAL 1117
W++ T+ + +F I+ D + + AIE +ENV+T++ L
Sbjct: 898 WQIAVVGTVMIALFALLMISMAYKIARVNLKQIKRD-----EAGKIAIEIVENVKTIQLL 952
Query: 1116 NLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVA 937
+ ++ + L+ HKS K+A IQ N +S + F V + GT L V
Sbjct: 953 TSTEHFLTEYTTALELQHKSEMKKAYIQALNNAISQTFMYFAMFVCYAVGTPLMYNGIVD 1012
Query: 936 PMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIE 757
P + + ++ M + ++ P++ KA AAG++F L Y G +
Sbjct: 1013 PNGAFRAINSMMMGSVAVMHSSHNFPEFVKAKTAAGMLFKLI-YRKPKTGDVMKGNQLDI 1071
Query: 756 KGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVD 577
+G I+ E+V+F Y QRP ++ ++ G+T+ALVGPSG GKST I++LERFY
Sbjct: 1072 RGNILFESVKFSYPQRPLHPVMTDLHFTARNGQTVALVGPSGTGKSTCIAMLERFYDVSG 1131
Query: 576 GEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTA 397
G ++ID ++++ ++L+HLR+ +ALV QEP LF +IREN+ +GL + VP ++ +AL+ A
Sbjct: 1132 GALRIDGQDIKTLSLHHLRTQMALVGQEPRLFAGTIRENVCFGL-KDVPIEKVNQALELA 1190
Query: 396 NAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEK 217
NA F+ P G+DT VGE+G+QLSGGQKQRIAIARA++R+PK+LLLDEATSALDS+SE+
Sbjct: 1191 NASRFLANLPSGIDTEVGEKGSQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESER 1250
Query: 216 VVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQ 37
V+Q ALD A E + + +AHRLS++ N+D I + GKV E G H L+ R Y+ L++
Sbjct: 1251 VMQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDQGKVQEAGNHNHLMSLRGKYYDLIK 1310
Query: 36 KQGI 25
KQ +
Sbjct: 1311 KQDL 1314
Score = 293 bits (749), Expect = 3e-77
Identities = 194/581 (33%), Positives = 300/581 (51%), Gaps = 41/581 (7%)
Frame = -1
Query: 3546 LGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQVVF 3367
+G +F++M G ++ FG V + + D E A E +V
Sbjct: 758 MGTVFAIMRGSELALLAIMFGYVFEAF------------EKPDAEMARE--------LVI 797
Query: 3366 HFFLCGCA---YFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVS--TGHL 3202
F L GC FI L + V +N + R Q LL +DA +FD+ + G L
Sbjct: 798 IFILYGCLGLYVFITQVLSSTLFTIVAENLGLKFRVQSFKNLLYQDASFFDNPAHAPGKL 857
Query: 3201 STVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFI 3022
T L + + V + ++ +I +T T+ + W++A G A I
Sbjct: 858 ITRLATDAPNVKAVVDTRMLQVIYSMTSITINLVTGYACCWQIAVVGTVMIALFALL-MI 916
Query: 3021 NSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRR 2842
+ A + + AG IA + + KT+ L + + YT L+ K +++
Sbjct: 917 SMAYKIARVNLKQIKRDEAGKIAIEIVENVKTIQLLTSTEHFLTEYTTALELQHKSEMKK 976
Query: 2841 ALMYSISRGVTYFFCNSLNTVVLYVGATMIYSGTLETAVVVRDDN--------------- 2707
A + +++ ++ F V VG ++Y+G ++ R N
Sbjct: 977 AYIQALNNAISQTFMYFAMFVCYAVGTPLMYNGIVDPNGAFRAINSMMMGSVAVMHSSHN 1036
Query: 2706 -----------------VIEKDETDYDV----EVEVNGNISFKNVKFSYPTRPDAQVLKG 2590
+ K +T DV ++++ GNI F++VKFSYP RP V+
Sbjct: 1037 FPEFVKAKTAAGMLFKLIYRKPKTG-DVMKGNQLDIRGNILFESVKFSYPQRPLHPVMTD 1095
Query: 2589 ISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGV 2410
+ F +NG+ +ALVG SG+GKST + +L +Y++ G + IDG D+ +++ LR + +
Sbjct: 1096 LHFTARNGQTVALVGPSGTGKSTCIAMLERFYDVSGGALRIDGQDIKTLSLHHLRTQMAL 1155
Query: 2409 VSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLS 2230
V QEP LF TI EN+ FG +V + ++ AL ANA F+ + P GI T VGE+G+QLS
Sbjct: 1156 VGQEPRLFAGTIRENVCFGLKDVPIEKVNQALELANASRFLANLPSGIDTEVGEKGSQLS 1215
Query: 2229 GGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTI 2050
GGQKQRIAIAR LVR+PKILLLDEATSALD+ESE+V+Q+AL+ A +GRT I +AHRLS+I
Sbjct: 1216 GGQKQRIAIARALVRDPKILLLDEATSALDSESERVMQEALDRAREGRTCITIAHRLSSI 1275
Query: 2049 RNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLES 1927
+N+ I+ + +G++ E GNH+ L++ RG Y DL++ Q L S
Sbjct: 1276 QNSDLIVYIDQGKVQEAGNHNHLMSLRGKYYDLIKKQDLTS 1316
>gi|17567269|ref|NP_510128.1| P-GlycoProtein related (146.8 kD)
(pgp-14) [Caenorhabditis elegans]
gi|7499665|pir||T21268 hypothetical protein F22E10.3 - Caenorhabditis
elegans
gi|3876293|emb|CAA91801.1| Hypothetical protein F22E10.3
[Caenorhabditis elegans]
gi|40764042|gb|AAR89639.1| P-glycoprotein related (146.8 kD) (pgp-14)
[Caenorhabditis elegans]
Length = 1327
Score = 690 bits (1781), Expect = 0.0
Identities = 425/1257 (33%), Positives = 681/1257 (53%), Gaps = 67/1257 (5%)
Frame = -1
Query: 3588 VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEK 3409
+F+ F+ L +G + ++++G QP ++ G V+ L+
Sbjct: 93 LFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYP--------------P 138
Query: 3408 AYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQY 3229
+++ N+ V+ F G I +Q+ ++ ++R +++ +L+++A +
Sbjct: 139 TSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGW 198
Query: 3228 FDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFS 3049
FD +G ++T LND++ER RE +K+ +++ +A+ +WRLAS + +
Sbjct: 199 FDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVA 258
Query: 3048 LGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELK 2869
+ + + TT K+ AGSIA ++L +TV + NGQ+ + RY EL+
Sbjct: 259 PTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELE 318
Query: 2868 AGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYSGTLETA----VVVRD---- 2713
G K+ + + G+ +F+ S + GA ++ G + T +VV
Sbjct: 319 KGRKFAVWKGFWSGFFGGLFFFWLFSFLGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLG 378
Query: 2712 ----------------------------DNVIEKDETDYDVE--VEVNGNISFKNVKFSY 2623
D V + D + V G + F+NV F Y
Sbjct: 379 AYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRY 438
Query: 2622 PTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDM 2443
P+R DA++L G++ V+ G +ALVG SG GKST V LL Y ++GN+ IDG D+ ++
Sbjct: 439 PSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVREL 498
Query: 2442 NIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIK 2263
NI+ LR +G+V QEP+LFN TI N+ GNP + + + ANA+DF+ PKG
Sbjct: 499 NIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYD 558
Query: 2262 TIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRT 2083
T++G+ G QLSGGQKQR+AIARTL+R+PK+LLLDEATSALD +SE +VQ AL NAS+GRT
Sbjct: 559 TLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRT 618
Query: 2082 TIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLL----ESHDDH 1915
TI++AHRLSTIR A KI+ +KG IVE GNH+EL+ G Y DLV+AQ E+ ++
Sbjct: 619 TIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKADPEATEEF 678
Query: 1914 EEL------PPLAARQLSQELSPLHSYAIQRSTSNDAGVHDDDMERILDE---------- 1783
EE ++R+ S + S A +R S + D
Sbjct: 679 EEEEIDLDDTSRSSRRSSMTSARSGSEAFRRGNSLNDSFSGSKRSAQADAENSAFAANEA 738
Query: 1782 --LSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMI-- 1615
++++G + +I K + +Y ++F+ + I+G+ P LA + +EGF +
Sbjct: 739 AIMAEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPY 798
Query: 1614 GEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFY 1435
G M++ + ++F + V + F VSE LS R R++SF ++L +++
Sbjct: 799 GGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYF 858
Query: 1434 DDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKM-----TL 1270
D+P H+ +L RL +D+ N+KA VD R+ VI + AI I A +YCW++ +L
Sbjct: 859 DNPAHAPGKLITRLASDAPNIKAVVDARMLQVIYALAAIIANIAIAFIYCWQIGILGTSL 918
Query: 1269 EVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSL 1090
+L+ F + + I +++ R AIE +ENV+T++ L +
Sbjct: 919 ILLLAF------VMIGLAYKISLMNVEQIQNDDAGRIAIEIIENVKTIQLLTRCELFFDH 972
Query: 1089 ISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLM 910
++ +S K+ +I+ L+ S F+ ++ G + + + + DT+ ++
Sbjct: 973 YQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGII 1032
Query: 909 TLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGENV 730
+ + A ++A Y P++ KA AAG++F++ Y +G + +G I+ ENV
Sbjct: 1033 AMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNII-YRKPRTGDLMEGDRPEIRGNILFENV 1091
Query: 729 QFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSEN 550
+F Y QRP + I+ G+ G+T+ALVGPSG GKST I +LERFY G ++ID ++
Sbjct: 1092 KFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQD 1151
Query: 549 VEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQF 370
+ ++L HLR+ +ALV QEP LF +IREN+ GL + VP ++ +AL+ ANA F+
Sbjct: 1152 IRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGL-KDVPLEKINQALELANANRFLANL 1210
Query: 369 PQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTA 190
P G+DT VGE+G QLSGGQKQRIAIARA++R+PK+LLLDEATSALDS+SE+ VQ ALD A
Sbjct: 1211 PAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRA 1270
Query: 189 SERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQV 19
E + + +AHRLS++ N+D I + GKV E G H +L+ ++ Y++L++KQ + V
Sbjct: 1271 REGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQDLAV 1327
Score = 308 bits (789), Expect = 6e-82
Identities = 194/574 (33%), Positives = 298/574 (51%), Gaps = 5/574 (0%)
Frame = -1
Query: 1722 DYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYYSHLW---ALSFMFLAVF 1552
DY LFI + I GVS PILA + R + + + F+ + +F
Sbjct: 101 DYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKANENVYIFLGIGIF 160
Query: 1551 RPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNV 1372
+T + QY F ++ ++R + +L ++D NHS T ++ +LN +
Sbjct: 161 ISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFDK-NHSGT-ITTKLNDSMERI 218
Query: 1371 KAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQE 1192
+ + D+LG ++ + AI A +Y W++ +L P +
Sbjct: 219 REGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIK 278
Query: 1191 DTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLS 1012
+ I + A E+L VRTV+A N +++++ L+K K + G GL
Sbjct: 279 ELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKGFWSGFFGGLF 338
Query: 1011 LSCFLFVYSVSFKFGTYLALRKEVA-PMDTYLVLMTLSMTANMAGSAAAYLPDYKKA-VH 838
+G YL + P D ++V+M++ + A G + ++ A V
Sbjct: 339 FFWLFSFLGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVS 398
Query: 837 AAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGK 658
AA + + P P+S + + G + ENV F Y R D ILNG+NL V+PG
Sbjct: 399 AASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGT 458
Query: 657 TLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFN 478
++ALVG SGCGKST + LL R Y G V ID +V ++N+ LR+ + +V QEP LFN
Sbjct: 459 SVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFN 518
Query: 477 CSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIA 298
+I NLL G S + +E + ANA +F+ + P+G DTL+G+ G QLSGGQKQR+A
Sbjct: 519 DTIHNNLLIGNPGSTRETMIE-VCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVA 577
Query: 297 IARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAV 118
IAR ++R+PKVLLLDEATSALD+ SE +VQ+AL+ AS+ +T+++AHRLST+ AD I
Sbjct: 578 IARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVF 637
Query: 117 LKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQVE 16
+ G + E G HEEL+R Y+ LV+ Q + +
Sbjct: 638 FEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKAD 671
>gi|27656758|gb|AAO20902.1| Mdr2 [Takifugu rubripes]
Length = 1271
Score = 689 bits (1779), Expect = 0.0
Identities = 443/1300 (34%), Positives = 669/1300 (51%), Gaps = 133/1300 (10%)
Frame = -1
Query: 3531 SLMTGFCQPFMSYTFGEVSQVLVTITN-AINNKTIDPADLEKAYEEYERGMNQVVFHFFL 3355
+++ G P M FGE++ + + N+ T +P +A E M + ++ +
Sbjct: 2 AIVNGLVNPLMCIVFGEMTDSFIQEAKLSQNHNTSNP----RANSTLEADMQRFSIYYSI 57
Query: 3354 CGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLND--- 3184
G A + A LQ ++ R+R+ + ++++D ++D TG L+T L +
Sbjct: 58 LGFAVLVVAYLQMSLWTLTAARQAKRIRELFFHGIMQQDISWYDVTETGELNTRLTEWVT 117
Query: 3183 --------------------------NLERFREVFNEKIALIIAFVTDFTLGTALAFYTD 3082
++ + +E +K L+I + F + F
Sbjct: 118 HIIHTPVPVTAGVVVIICGVRFPGAHDVYKIQEGIGDKAGLLIQAASTFITSFVIGFVHG 177
Query: 3081 WRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQK 2902
W+L + S + S + S + T K+ T YA AG++A + L + +TV + +GQ+
Sbjct: 178 WKLTLVILAISPVLGLSAALYSKLLTSFTSKEQTAYAKAGAVAAEVLSSIRTVFAFSGQR 237
Query: 2901 TEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATM----------- 2755
I+RY + L+ GI++ + + + G ++ + + G T+
Sbjct: 238 KAIKRYHKNLEDARDMGIKKGVAANTATGFSFLMIYLSYALAFWYGTTLVLNKEYTIGNL 297
Query: 2754 -----IYSGTLETAVVVR--------------------------------------DDNV 2704
+ + T+ T V ++ N+
Sbjct: 298 LTNKSVAAETVTTCVQMKVFFVVLYGAYIIGQASPNVQSFASARGAAYKVYNIIDHKPNI 357
Query: 2703 IEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKS 2524
E Y E + G+I F+N+ FSYP+RP+ ++L +SF V+NG+ IALVG+SG GKS
Sbjct: 358 DSFSEDGYKPEY-IKGDIVFQNIHFSYPSRPEIKILNDMSFHVRNGQTIALVGSSGCGKS 416
Query: 2523 TVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPN 2344
T +QLL +Y+ G+IFIDG D+ +NI+ LR +IGVVSQEPVLF TTI ENIR+G +
Sbjct: 417 TTIQLLQRFYDPQKGSIFIDGHDIRSLNIRYLREMIGVVSQEPVLFATTITENIRYGRLD 476
Query: 2343 VSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLL 2164
V+ EI A +++NAYDF+ + P +T+VG+RGTQLSGGQKQRIAIAR LVRNPKILLL
Sbjct: 477 VTQEEIERATKESNAYDFIMNLPDKFETLVGDRGTQLSGGQKQRIAIARALVRNPKILLL 536
Query: 2163 DEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDE 1984
DEATSALD ESE +VQ AL+ GRTTIV+AHRLSTIRNA I GEIVE G H +
Sbjct: 537 DEATSALDAESETIVQAALDKVRLGRTTIVIAHRLSTIRNADIIAGFSNGEIVEQGTHSQ 596
Query: 1983 LIAKRGVYNDLVQAQLLESHDDHE--ELPPLAARQLSQELSPLHSYAIQRSTSNDAGVHD 1810
L+ +GVY+ LV Q + +D E + P A + SQ + ++QR S +
Sbjct: 597 LMEIKGVYHGLVTMQSFQKLEDLEDSDYEPWVAEK-SQLIESFSQSSLQRRRSTRGSLLA 655
Query: 1809 DDMERILDELSKEGAKKSNLRE-----------IVKQCRPDYCFLFIAVFGSAIQGVSYP 1663
E +E K + N+ E +++ ++ ++ + + I G P
Sbjct: 656 VS-EGTKEEKEKFECDQDNIEEDENVPPVSFFKVMRYNVSEWPYILVGTICAMINGAMQP 714
Query: 1662 ILAQLIVRTYEGFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRL 1483
+ F++I +++ + W Q + F K E L+ L
Sbjct: 715 V-----------FSIIFTEIIMF---WGF---------------QGFCFSKSGEILTLNL 745
Query: 1482 RIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAIT 1303
R+K+F M+ ++YD+P ++ L+ RL D+++V+ A RL + + +I
Sbjct: 746 RLKAFISMMRQDLSWYDNPKNTVGALTTRLAADAAHVQGAAGVRLAVMTQNFANLGTSII 805
Query: 1302 TASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVR 1123
+ +Y W++TL +L P ED E + + A EA+ENVRTV
Sbjct: 806 ISFVYGWELTLLILAVVPILAVAGAAEVKLLTGHAAEDKKELEMAGKIATEAIENVRTVV 865
Query: 1122 ALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKE 943
+L E ++L E+L +K+ K+A I G S + FVY+ F+FG +L
Sbjct: 866 SLTREPTFVALYEENLTVPYKNSQKKAKIYGLTYSFSQAMIFFVYAACFRFGAWLIEAGR 925
Query: 942 VAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKA-VHAAGLIFHLFTYPATMPFSSSDGKK 766
+ +LV+MT+ A G A Y P++ KA + A+ L + PA S + +
Sbjct: 926 MDVEGVFLVVMTMLYGAMAVGEANTYAPNFAKAKISASHLTMLINRQPAIDNLSEEEARL 985
Query: 765 NIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYH 586
G ++ E+V+F+Y RPD +L G+NL+V G+TLALVG SGCGKST I LLERFY
Sbjct: 986 EKYDGNVLFEDVKFNYPSRPDVPVLQGLNLEVQKGETLALVGSSGCGKSTTIQLLERFYD 1045
Query: 585 AVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYG-LTRSVPQLELEKA 409
+G V +D +V+ +N++ LRS + +VSQEP LF+CS+ EN+ YG +RSV E+ A
Sbjct: 1046 PREGRVLLDGVDVKQLNVHWLRSQIGIVSQEPVLFDCSLAENIAYGDNSRSVSMDEIVAA 1105
Query: 408 LQTANAFNFVFQFP----------------------------------QGLDTLVGERGA 331
+ AN +F+ P Q DT G++G
Sbjct: 1106 AKAANIHSFIEGLPQVAAVNQGKWLIPHLIDSHGAAHDHLHHIQTVSEQRYDTQAGDKGT 1165
Query: 330 QLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRL 151
QLSGGQKQR+AIARAI+RNPK+LLLDEATSALD++SEKVVQ ALD A + + +VVAHRL
Sbjct: 1166 QLSGGQKQRVAIARAIIRNPKLLLLDEATSALDTESEKVVQEALDQARKGRTCIVVAHRL 1225
Query: 150 STVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
ST+ NAD IAV + G V E+GTH++L+ K+ +Y LV KQ
Sbjct: 1226 STIQNADCIAVFQGGVVVEKGTHQQLIAKKGVYHMLVTKQ 1265
Score = 302 bits (773), Expect = 4e-80
Identities = 171/472 (36%), Positives = 255/472 (53%), Gaps = 17/472 (3%)
Frame = -1
Query: 1386 DSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXX 1207
D ++ + D+ G +I + ++ WK+TL +L P
Sbjct: 144 DVYKIQEGIGDKAGLLIQAASTFITSFVIGFVHGWKLTLVILAISPVLGLSAALYSKLLT 203
Query: 1206 XAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGA 1027
++ A+ + A E L ++RTV A + + K + ++L+ K+ +
Sbjct: 204 SFTSKEQTAYAKAGAVAAEVLSSIRTVFAFSGQRKAIKRYHKNLEDARDMGIKKGVAANT 263
Query: 1026 ANGLSLSCFLFVYSVSFKFGTYLALRKE----------------VAPMDTYLVLMTLSMT 895
A G S Y+++F +GT L L KE V V +
Sbjct: 264 ATGFSFLMIYLSYALAFWYGTTLVLNKEYTIGNLLTNKSVAAETVTTCVQMKVFFVVLYG 323
Query: 894 ANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDG-KKNIEKGEIIGENVQFHY 718
A + G A+ + + A AA ++++ + + S DG K KG+I+ +N+ F Y
Sbjct: 324 AYIIGQASPNVQSFASARGAAYKVYNIIDHKPNIDSFSEDGYKPEYIKGDIVFQNIHFSY 383
Query: 717 DQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDI 538
RP+ ILN ++ V G+T+ALVG SGCGKST I LL+RFY G + ID ++ +
Sbjct: 384 PSRPEIKILNDMSFHVRNGQTIALVGSSGCGKSTTIQLLQRFYDPQKGSIFIDGHDIRSL 443
Query: 537 NLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGL 358
N+ +LR + +VSQEP LF +I EN+ YG V Q E+E+A + +NA++F+ P
Sbjct: 444 NIRYLREMIGVVSQEPVLFATTITENIRYGRL-DVTQEEIERATKESNAYDFIMNLPDKF 502
Query: 357 DTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERL 178
+TLVG+RG QLSGGQKQRIAIARA++RNPK+LLLDEATSALD++SE +VQ ALD
Sbjct: 503 ETLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAESETIVQAALDKVRLGR 562
Query: 177 STVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQ 22
+T+V+AHRLST+ NAD IA NG++ EQGTH +L+ + +Y LV Q Q
Sbjct: 563 TTIVIAHRLSTIRNADIIAGFSNGEIVEQGTHSQLMEIKGVYHGLVTMQSFQ 614
Score = 271 bits (694), Expect = 6e-71
Identities = 181/530 (34%), Positives = 278/530 (52%), Gaps = 76/530 (14%)
Frame = -1
Query: 3297 GDNTTYRVRKQYISRLLKKDAQYFDSV--STGHLSTVLNDNLERFREVFNEKIALIIAFV 3124
G+ T +R + ++++D ++D+ + G L+T L + + ++A++
Sbjct: 738 GEILTLNLRLKAFISMMRQDLSWYDNPKNTVGALTTRLAADAAHVQGAAGVRLAVMTQNF 797
Query: 3123 TDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQT 2944
+ ++F W L + +A +G + + AG IA +
Sbjct: 798 ANLGTSIIISFVYGWELTLLILAVVPILAVAGAAEVKLLTGHAAEDKKELEMAGKIATEA 857
Query: 2943 LGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRA----LMYSISRGVTYFF---CNSLN 2785
+ +TV SL + T + Y E L K ++A L YS S+ + +F C
Sbjct: 858 IENVRTVVSLTREPTFVALYEENLTVPYKNSQKKAKIYGLTYSFSQAMIFFVYAACFRFG 917
Query: 2784 TVVLYVGA-----------TMIY--------------------SGTLETAVVVRDDNVIE 2698
++ G TM+Y S + T ++ R +
Sbjct: 918 AWLIEAGRMDVEGVFLVVMTMLYGAMAVGEANTYAPNFAKAKISASHLTMLINRQPAIDN 977
Query: 2697 KDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTV 2518
E + +E + +GN+ F++VKF+YP+RPD VL+G++ +VQ GE +ALVG+SG GKST
Sbjct: 978 LSEEEARLE-KYDGNVLFEDVKFNYPSRPDVPVLQGLNLEVQKGETLALVGSSGCGKSTT 1036
Query: 2517 VQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPN-- 2344
+QLL +Y+ G + +DG+D+ +N+ LR IG+VSQEPVLF+ ++ ENI +G+ +
Sbjct: 1037 IQLLERFYDPREGRVLLDGVDVKQLNVHWLRSQIGIVSQEPVLFDCSLAENIAYGDNSRS 1096
Query: 2343 VSLPEIYGALRKANAYDFVCSFPK--------------------------GIKTI----- 2257
VS+ EI A + AN + F+ P+ I+T+
Sbjct: 1097 VSMDEIVAAAKAANIHSFIEGLPQVAAVNQGKWLIPHLIDSHGAAHDHLHHIQTVSEQRY 1156
Query: 2256 ---VGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGR 2086
G++GTQLSGGQKQR+AIAR ++RNPK+LLLDEATSALD ESE+VVQ+AL+ A +GR
Sbjct: 1157 DTQAGDKGTQLSGGQKQRVAIARAIIRNPKLLLLDEATSALDTESEKVVQEALDQARKGR 1216
Query: 2085 TTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQL 1936
T IVVAHRLSTI+NA I V Q G +VE G H +LIAK+GVY+ LV Q+
Sbjct: 1217 TCIVVAHRLSTIQNADCIAVFQGGVVVEKGTHQQLIAKKGVYHMLVTKQM 1266
>gi|6472653|dbj|BAA87071.1| multi-drug resistance related mRNA [Felis
catus]
Length = 1163
Score = 688 bits (1776), Expect = 0.0
Identities = 415/1164 (35%), Positives = 627/1164 (53%), Gaps = 54/1164 (4%)
Frame = -1
Query: 3519 GFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEKAYEEY-----ERGMNQVVFHFFL 3355
G P M FG+++ + N T++ + Y E M +++
Sbjct: 2 GAALPLMMLVFGDMTDSFANAGISRNLTTLNITGESIVNDSYFINRLEEEMTTYAYYYSG 61
Query: 3354 CGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLE 3175
G + A +Q + ++RKQ+ +++++ +FD G L+T L D++
Sbjct: 62 IGAGVLVAAYIQVSFWCLAAGRQILKIRKQFFHAIMRQEVGWFDVHDVGELNTRLTDDVS 121
Query: 3174 RFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTT 2995
+ E +KI + + F +G + F W+L + S + S I + + T
Sbjct: 122 KINEGIGDKIGMFFQSMATFFIGFIVGFTRGWKLTLVILAISPVLGLSAAIWAKILSSFT 181
Query: 2994 GKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRG 2815
K+ YA AG++A + L A +TV + GQK E+ERY + L+ ++ GI++A+ +IS G
Sbjct: 182 DKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIG 241
Query: 2814 VTYFFCNSLNTVVLYVGATMIYS------------------------------------- 2746
+ + + + + G +++ S
Sbjct: 242 IAFLLIYASYALAFWYGTSLVLSHEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARG 301
Query: 2745 GTLETAVVVRDDNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNG 2566
E ++ + I+ + + GN+ FKNV FSYP+R + ++LKG++ VQ+G
Sbjct: 302 AAYEIFKIIDNKPSIDSYSKNGHKPDNIKGNLEFKNVHFSYPSRKEVKILKGLNLKVQSG 361
Query: 2565 ECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLF 2386
+ +ALVG SG GKST VQL+ Y+ G + IDG D+ +N++ LR +IGVVSQEPVLF
Sbjct: 362 QTVALVGNSGCGKSTTVQLMQRLYDPTDGMVSIDGQDIRTINVRYLREIIGVVSQEPVLF 421
Query: 2385 NTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIA 2206
TTI ENIR+G NV++ EI A+++ANAYDF+ P T+VGERG QLSGGQKQRIA
Sbjct: 422 ATTIAENIRYGRENVTMEEIEKAVKEANAYDFIMKLPNKFDTLVGERGAQLSGGQKQRIA 481
Query: 2205 IARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIV 2026
IAR LVRNPKILLLDEATSALD+ESE VVQ AL+ A +GRTTIVVAHRLSTIRNA I
Sbjct: 482 IARALVRNPKILLLDEATSALDSESEAVVQVALDKARKGRTTIVVAHRLSTIRNADVIAG 541
Query: 2025 MQKGEIVEVGNHDELIAKRGVYNDLVQAQLLESHDDHEELPPLAARQLSQ----ELSPLH 1858
G IVE GNHDEL+ + G+Y LV +++ + EL +S+ E+SP
Sbjct: 542 FDDGVIVEKGNHDELMKEEGIYFKLV---TMQTRGNEIELENAVYESISEIDALEMSPKD 598
Query: 1857 S-YAIQRSTSNDAGVH---DDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFG 1690
S ++ R S +H D + E E + I+K ++ + + +F
Sbjct: 599 SGSSLIRRRSTRKSIHASQGQDRKLGTKENLDERVPPVSFWRILKLNITEWPYFVVGIFC 658
Query: 1689 SAIQGVSYPILAQLIVRTYEGFAMI--GEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYF 1516
+ I G P + ++ R F + E S++++L F+ L + +T + Q + F
Sbjct: 659 AIINGGLQPAFSVILSRIIGVFTRVEDPETKRQNSNIFSLLFLVLGIISSITFFLQGFTF 718
Query: 1515 GKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVI 1336
GK E L+ RLR F ML +++DDP ++ L+ RL D++ VK A+ RL +
Sbjct: 719 GKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAIIT 778
Query: 1335 MTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTA 1156
+ + I + +Y W++TL +L P +D E + + A
Sbjct: 779 QNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKVA 838
Query: 1155 IEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSF 976
EA+EN RTV +L E K + ++ LQ +++ ++A I G + ++ + F Y+ F
Sbjct: 839 TEAIENFRTVVSLTREQKFEYMYAQSLQVPYRNSLRKAHIFGISFSITQAMMYFSYAGCF 898
Query: 975 KFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKA-VHAAGLIFHLFTYPA 799
+FG YL + + D LV + A G +++ PDY KA V AA +I + P
Sbjct: 899 RFGAYLVAHEFMDFQDVLLVFSAIVFGAMAVGQVSSFAPDYAKAKVSAAHVIMIIEKIPL 958
Query: 798 TMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKS 619
+S+ N +G + V F+Y RPD +L G++L+V G+TLALVG SGCGKS
Sbjct: 959 IDSYSTEGLMPNTLEGNVTFNEVMFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKS 1018
Query: 618 TIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYG-LT 442
T++ LLERFY + G V ID + ++ +N+ LR+++ +VSQEP LF+CSI EN+ YG +
Sbjct: 1019 TVVQLLERFYDPMAGTVLIDGKEIKHLNVQWLRAHMGIVSQEPILFDCSIGENIAYGDNS 1078
Query: 441 RSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVL 262
R V Q E+ +A + AN F+ P +T VG++G QLSGGQKQRIAIARA++R P++L
Sbjct: 1079 RVVSQEEIVRAAKEANIHPFIETLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPRIL 1138
Query: 261 LLDEATSALDSDSEKVVQNALDTA 190
LLDEATSALD++SEKVVQ ALD A
Sbjct: 1139 LLDEATSALDTESEKVVQEALDKA 1162
Score = 325 bits (833), Expect = 5e-87
Identities = 190/510 (37%), Positives = 290/510 (56%), Gaps = 3/510 (0%)
Frame = -1
Query: 1536 YCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVD 1357
Y Q ++ + + ++R + F ++ ++D H L+ RL D S + +
Sbjct: 71 YIQVSFWCLAAGRQILKIRKQFFHAIMRQEVGWFDV--HDVGELNTRLTDDVSKINEGIG 128
Query: 1356 DRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAF 1177
D++G ++ I WK+TL +L P ++ +A+
Sbjct: 129 DKIGMFFQSMATFFIGFIVGFTRGWKLTLVILAISPVLGLSAAIWAKILSSFTDKELLAY 188
Query: 1176 ENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFL 997
+ A E L +RTV A + K + +++L++ + K+AI + G++
Sbjct: 189 AKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGIAFLLIY 248
Query: 996 FVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFH 817
Y+++F +GT L L E + V ++ + A G A+ + + A AA IF
Sbjct: 249 ASYALAFWYGTSLVLSHEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFK 308
Query: 816 LF-TYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVG 640
+ P+ +S + K + KG + +NV F Y R + IL G+NLKV G+T+ALVG
Sbjct: 309 IIDNKPSIDSYSKNGHKPDNIKGNLEFKNVHFSYPSRKEVKILKGLNLKVQSGQTVALVG 368
Query: 639 PSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIREN 460
SGCGKST + L++R Y DG V ID +++ IN+ +LR + +VSQEP LF +I EN
Sbjct: 369 NSGCGKSTTVQLMQRLYDPTDGMVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAEN 428
Query: 459 LLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAIL 280
+ YG +V E+EKA++ ANA++F+ + P DTLVGERGAQLSGGQKQRIAIARA++
Sbjct: 429 IRYG-RENVTMEEIEKAVKEANAYDFIMKLPNKFDTLVGERGAQLSGGQKQRIAIARALV 487
Query: 279 RNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKV 100
RNPK+LLLDEATSALDS+SE VVQ ALD A + +T+VVAHRLST+ NAD IA +G +
Sbjct: 488 RNPKILLLDEATSALDSESEAVVQVALDKARKGRTTIVVAHRLSTIRNADVIAGFDDGVI 547
Query: 99 AEQGTHEELLRKRSIYWRLV--QKQGIQVE 16
E+G H+EL+++ IY++LV Q +G ++E
Sbjct: 548 VEKGNHDELMKEEGIYFKLVTMQTRGNEIE 577
>gi|9961252|ref|NP_061338.1| ATP-binding cassette, subfamily B, member
4 isoform C; P glycoprotein 3/multiple drug resistance 3;
P-glycoprotein-3/multiple drug resistance-3; multiple
drug resistance 3 [Homo sapiens]
Length = 1232
Score = 688 bits (1775), Expect = 0.0
Identities = 432/1242 (34%), Positives = 655/1242 (51%), Gaps = 53/1242 (4%)
Frame = -1
Query: 3597 IRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPAD 3418
+ +F+ S +K LG + ++ G P M FGE++ V +
Sbjct: 42 VLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLS 101
Query: 3417 LEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKD 3238
L + E M + +++ G + A +Q + ++R+++ +L+++
Sbjct: 102 LLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQE 161
Query: 3237 AQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGI 3058
+FD T L+T L D++ + E +K+ + V F G + F W+L +
Sbjct: 162 IGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIM 221
Query: 3057 FFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTE 2878
S + S + + + + K+ YA AG++A + LGA +TV + GQ E+ERY +
Sbjct: 222 AISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQK 281
Query: 2877 ELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYSG--TLETAVVV----- 2719
L+ ++ GI++A+ +IS G+ + + + + G+T++ S T+ A+ V
Sbjct: 282 HLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSIL 341
Query: 2718 -------------------RDDNVIEKDETDYDVEVE-----------VNGNISFKNVKF 2629
R + D D + +++ + GN+ F +V F
Sbjct: 342 IGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHF 401
Query: 2628 SYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLN 2449
SYP+R + ++LKG++ VQ+G+ +ALVG+SG GKST VQL+ Y+ D G I IDG D+
Sbjct: 402 SYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIR 461
Query: 2448 DMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKG 2269
+ N+ LR +IGVVSQEPVLF+TTI ENI +G NV++ EI A+++ANAY+F+ P+
Sbjct: 462 NFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQK 521
Query: 2268 IKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQG 2089
T+VGERG QLSGGQKQRIAIAR LVRNPKILLLDEATSALD ESE VQ AL+ A +G
Sbjct: 522 FDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREG 581
Query: 2088 RTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLESHDDHEE 1909
RTTIV+AHRLST+RNA I + G IVE G+H EL+ K GVY LV Q S EE
Sbjct: 582 RTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEE 641
Query: 1908 LPPLAARQLSQELSP------LHSYAIQRSTSN------DAGVHDDDMERILDELSKEGA 1765
L + + ++P L ++ Q++ N V D +E + +S
Sbjct: 642 F-ELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVS---- 696
Query: 1764 KKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYYS-- 1591
+++K + ++ + + + G P + + F G+D +
Sbjct: 697 ----FLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGP-GDDAVKQQKC 751
Query: 1590 HLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSAT 1411
++++L F+FL + T + Q + FGK E L+ RLR +F ML +++DD +S
Sbjct: 752 NIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTG 811
Query: 1410 RLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXX 1231
LS RL TD++ V+ A RL + + + I + +Y W++TL +L P
Sbjct: 812 ALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSG 871
Query: 1230 XXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYF 1051
+ D E + + A EA+EN+RTV +L E K S+ E L ++ +
Sbjct: 872 IVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRVF- 930
Query: 1050 KRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAA 871
AI+ GA G A+
Sbjct: 931 -SAIVFGAV---------------------------------------------ALGHAS 944
Query: 870 AYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDG-KKNIEKGEIIGENVQFHYDQRPDRMI 694
++ PDY KA +A +F LF + S +G K + +G I V F+Y R + +
Sbjct: 945 SFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPV 1004
Query: 693 LNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSN 514
L G++L+V G+TLALVG SGCGKST++ LLERFY + G V +D + + +N+ LR+
Sbjct: 1005 LQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQ 1064
Query: 513 LALVSQEPTLFNCSIRENLLYG-LTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGER 337
L +VSQEP LF+CSI EN+ YG +R V Q E+ A + AN F+ P +T VG++
Sbjct: 1065 LGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDK 1124
Query: 336 GAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAH 157
G QLSGGQKQRIAIARA++R P++LLLDEATSALD++SEKVVQ ALD A E + +V+AH
Sbjct: 1125 GTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAH 1184
Query: 156 RLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
RLST+ NAD I V +NG+V E GTH++LL ++ IY+ +V Q
Sbjct: 1185 RLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ 1226
Score = 330 bits (847), Expect = 1e-88
Identities = 191/511 (37%), Positives = 290/511 (56%), Gaps = 3/511 (0%)
Frame = -1
Query: 1536 YCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVD 1357
Y Q ++ + + ++R K F +L ++D + T L+ RL D S + +
Sbjct: 132 YIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDI--NDTTELNTRLTDDISKISEGIG 189
Query: 1356 DRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAF 1177
D++G V + WK+TL ++ P ++ A+
Sbjct: 190 DKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAY 249
Query: 1176 ENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFL 997
+ A EAL +RTV A ++K + +HL+ + K+AI + G++
Sbjct: 250 AKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIY 309
Query: 996 FVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFH 817
Y+++F +G+ L + KE + V ++ + A G AA + + A AA +IF
Sbjct: 310 ASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFD 369
Query: 816 LF-TYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVG 640
+ P FS K + KG + +V F Y R + IL G+NLKV G+T+ALVG
Sbjct: 370 IIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVG 429
Query: 639 PSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIREN 460
SGCGKST + L++R Y +G + ID +++ + N+N+LR + +VSQEP LF+ +I EN
Sbjct: 430 SSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAEN 489
Query: 459 LLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAIL 280
+ YG +V E++KA++ ANA+ F+ + PQ DTLVGERGAQLSGGQKQRIAIARA++
Sbjct: 490 ICYG-RGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALV 548
Query: 279 RNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKV 100
RNPK+LLLDEATSALD++SE VQ ALD A E +T+V+AHRLSTV NAD IA ++G +
Sbjct: 549 RNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVI 608
Query: 99 AEQGTHEELLRKRSIYWRLV--QKQGIQVET 13
EQG+H EL++K +Y++LV Q G Q+++
Sbjct: 609 VEQGSHSELMKKEGVYFKLVNMQTSGSQIQS 639
>gi|17567267|ref|NP_510127.1| P-GlycoProtein related (pgp-13)
[Caenorhabditis elegans]
gi|7499664|pir||T21267 hypothetical protein F22E10.2 - Caenorhabditis
elegans
gi|3876292|emb|CAA91800.1| Hypothetical protein F22E10.2
[Caenorhabditis elegans]
Length = 1291
Score = 686 bits (1769), Expect = 0.0
Identities = 422/1237 (34%), Positives = 682/1237 (55%), Gaps = 47/1237 (3%)
Frame = -1
Query: 3588 VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEK 3409
+F+ ++ F+ L L+G++ S+++G QP ++ G ++ VL+ I DP
Sbjct: 81 LFRFATTFDYILLLIGLITSVISGVSQPVLAIISGRMTNVLLVI---------DPLS--- 128
Query: 3408 AYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQY 3229
+E++ + V+ F G I Q+ + V +R +YIS +L+++A +
Sbjct: 129 --KEFKTKTMENVYIFLGLGIFVSINDFCQYMCFQRVCSRMMTVMRNRYISSILRQNAGW 186
Query: 3228 FDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFS 3049
FD +G ++T LNDN+ER ++ +K+ ++I ++ ++ +WRLA +
Sbjct: 187 FDKNLSGTITTRLNDNMERIQDGVGDKLGVLIRGISMVIASVVISLIYEWRLALMMLGLI 246
Query: 3048 LGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELK 2869
+ S + K+TG++ AG+IA + L +T+ + NGQ+ + +Y ++L
Sbjct: 247 PVSTICMTLLSRFLEKSTGEELEKVGEAGAIAEECLMGVRTIQAFNGQEEMVAKYEKQLN 306
Query: 2868 AGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYSGTLETAVVVRD-------- 2713
+G+K+ I G+ +F+ ++ ++G ++Y G L +++
Sbjct: 307 SGKKHAIWGGFWSGFFGGIFFFW------LMAFMGCGILYGGYLLKVGIIKSPAASIYKT 360
Query: 2712 -DNVIEKDE-TDYDVEVE-VNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGA 2542
D V + D + + ++E V G ++F+NV F YPTR +A+VL G++ V+ G +ALVG
Sbjct: 361 IDRVPKIDPYSRHGKKIEKVVGKVTFENVHFRYPTRKEAKVLNGLNLTVEPGTSVALVGH 420
Query: 2541 SGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENI 2362
SG GKST V LL Y + G++ IDG+D+ D+N++ LR V+G+V QEP+LFN TI N+
Sbjct: 421 SGCGKSTSVGLLTRLYEPEQGSVQIDGVDVRDLNLEWLRNVVGIVQQEPILFNDTIHNNL 480
Query: 2361 RFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRN 2182
FGNP+ + + + ANA+DF+ PKG T +G+ G QLSGGQKQR+AIARTL+R+
Sbjct: 481 LFGNPDATRETMIRVCKMANAHDFIKKMPKGYDTQIGDGGVQLSGGQKQRVAIARTLIRD 540
Query: 2181 PKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVE 2002
PK+LLLDEATSALD +SE VVQ AL NAS+GRTTI++AHRLSTIR A KI+ +KG IVE
Sbjct: 541 PKVLLLDEATSALDAQSESVVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVE 600
Query: 2001 VGNHDELIAKRGVYNDLVQAQLL-----------ESHDDHEEL--PPLAARQLSQELSPL 1861
GNH+EL+ G Y DLV+AQ E D +E P + R++S S
Sbjct: 601 AGNHEELVNLGGRYFDLVKAQAFKQDPDEIALEKEEEDQFDEFDKPTVFNRKVSVRNSRS 660
Query: 1860 ----------------HSYAIQRSTSNDAGVHDDDME-RILDELSKEGAKKSNLREIVKQ 1732
HS+ R S+ D+ R+ + + K+G + +I K
Sbjct: 661 SGRSGSEEFRRGSLANHSFDRFRKASHIPSAEDEAFALRVKETMEKDGEITAGFLDIFKN 720
Query: 1731 CRP-DYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMI--GEDMLYYSHLWALSFMFL 1561
+ +Y ++ I + + I+G+ P A L +EGF + G M++ + ++
Sbjct: 721 AQGRNYTYMLIGLSAALIRGLDLPTFALLFAWVFEGFEFVPYGGKMMHRLAMSVIAHCAA 780
Query: 1560 AVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDS 1381
+ F VSE L R R+ +F ++L A++D+P H+ L RL D
Sbjct: 781 GLGIWFFQTLSTVMFAIVSENLGVRFRVAAFRNLLYQDAAYFDNPAHAPGSLITRLAADP 840
Query: 1380 SNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTL--EVLMFFPXXXXXXXXXXXXXX 1207
VKA VD R+ V+ A+ +T + CW++ + L+F
Sbjct: 841 PCVKAVVDGRMMQVVYATAAVIACVTIGFINCWQVAILGTALIFL---LGFIMAGLAFKI 897
Query: 1206 XAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGA 1027
+ + + +++ + AIE +ENV+T++ L + ++ +K ++ ++++ +
Sbjct: 898 SIVAAEHMENDDAGKIAIEIIENVKTIQLLTRTRRFLNSYENESKKRKRTELRKSVYEAV 957
Query: 1026 ANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKK 847
+S + ++ F + + + T+ LM + + +A + P +
Sbjct: 958 NYCISQNFMYYMSCFCFALAIRIINQGDQTVDKTFRCLMAMMLCCEGIIMSAQFFPQFVG 1017
Query: 846 AVHAAGLIFHLFT-YPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKV 670
A AAG +F+L P T S G K +G I+ ENV+F Y QRP + ++ +
Sbjct: 1018 AKSAAGQMFNLINRQPQTGDLKS--GTKPEIRGNILFENVKFSYPQRPHQPVMKQLQWTA 1075
Query: 669 DPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEP 490
G+T+ALVGPSG GKST I +LERFY G +++D +++++I+L HLR+ +ALV QEP
Sbjct: 1076 LRGQTVALVGPSGSGKSTCIGMLERFYDVTGGALRMDGQDIKNISLYHLRTQMALVGQEP 1135
Query: 489 TLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQK 310
LF +IREN+ GL + VP ++ +AL+ ANA F+ P G+DT VGERG QLSGGQK
Sbjct: 1136 RLFVGTIRENVCLGL-KDVPLEKINQALELANANRFLGNLPDGIDTEVGERGGQLSGGQK 1194
Query: 309 QRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNAD 130
QRIAIARA++R+PK+LLLDEATSALDS+SE+ VQ ALD A E + + +AHRLS++ N+D
Sbjct: 1195 QRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSD 1254
Query: 129 SIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQV 19
I + +G+V E GTH+EL++ + Y+ L++KQ + +
Sbjct: 1255 LIVYIDDGRVQESGTHKELMQLKGKYFELIKKQDLAI 1291
>gi|18496816|gb|AAL74249.1| ABC transporter AbcB2 [Dictyostelium
discoideum]
Length = 1407
Score = 677 bits (1748), Expect = 0.0
Identities = 436/1294 (33%), Positives = 672/1294 (51%), Gaps = 108/1294 (8%)
Frame = -1
Query: 3588 VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEK 3409
+F+ + F+ L ++G + +L G P +S FG + + P +L
Sbjct: 128 LFRFAKPFDILLMIIGTIGALANGVSMPAISIVFGRLMN------------SFSPENLAD 175
Query: 3408 AYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQY 3229
+ + +F GC F+ + ++ A G+ R RK Y+ +LK++ +
Sbjct: 176 PNFDLVETVTSNAMYFIYIGCGVFVCSYVEVAFWMLAGERQAVRCRKAYLKAILKQEIGW 235
Query: 3228 FDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFS 3049
+D + LST ++ + F+E EKI + + F G + F + + +Y +FF
Sbjct: 236 YDVTKSSELSTRISSDTLLFQEAIGEKIGNFLHHTSTFICGFIVGF-VNGKNYNYYLFFC 294
Query: 3048 LGI-----AFSGFINSAGVMKT------TGKQNTHYANAGSIAFQTLGAYKTVCSLNGQK 2902
+ A + I +AG T T K YA AG +A + +G+ +TV + +G+
Sbjct: 295 WQLTLVIFALTPLIAAAGAFMTKMMADLTKKGQDAYAKAGGVAEEKIGSIRTVSTFSGEP 354
Query: 2901 TEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYS-------- 2746
E++RYTE LK G ++ +M I G+ + ++ + G +I
Sbjct: 355 FEVKRYTERLKEALDIGTKKGIMNGIGIGLVFLVLFGTYSLSFWYGGKLIVDRKWNPVPD 414
Query: 2745 -----GTLETA---------------------------------VVVRDDNVIEKDETDY 2680
G + T VV R+ +
Sbjct: 415 RPWQGGDVLTVFFSVIMGAMALGQASPNVASFANGRGAAFKIYEVVDRNSKIDPFSTEGR 474
Query: 2679 DVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLH 2500
+E V GNI ++N+ FSYP+RPD ++ + ++ G +ALVG SG GKS+V+ LL
Sbjct: 475 SIEETVQGNIEYRNIGFSYPSRPDVKIFNNFNLTIKKGTTVALVGDSGGGKSSVIGLLER 534
Query: 2499 YYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYG 2320
+Y+ D G +++DG ++ ++NI LRR IG+VSQEPVLF +I ENIR+GN N ++ +I
Sbjct: 535 FYDPDEGEVYLDGTNIKEINIHSLRRNIGLVSQEPVLFANSIAENIRYGNENATMDQIIE 594
Query: 2319 ALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALD 2140
A + ANA+DF+ + P+G T VGE+G Q+SGGQKQRIAIAR ++++PKILLLDEATSALD
Sbjct: 595 ACKTANAHDFISALPEGYDTQVGEKGVQMSGGQKQRIAIARAMIKDPKILLLDEATSALD 654
Query: 2139 NESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVY 1960
+++E +VQ+++E GRTTIV+AHRLSTI++A +I V++ G IVE+G H EL A GVY
Sbjct: 655 SQNELLVQQSIEKLMIGRTTIVIAHRLSTIQDADQIAVVKGGAIVEIGTHPELYALNGVY 714
Query: 1959 NDLVQAQLLESHDDHEELPPLAARQLSQELSPLH----SYAIQRS----------TSNDA 1822
LV Q + DD ++ +++ S++ S + S +I +S TS
Sbjct: 715 TQLVNRQ-QKGGDDGDKKKKKKSKESSKDESNNNIGPSSISIDKSIQSIGADSLETSTIG 773
Query: 1821 GVHDDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIV 1642
V+D+D ++ + K K + I+K R D+ I + G+ + G P+ + +
Sbjct: 774 LVNDNDNKKKKKKEKKPQEKSVPIGRILKLSRGDWPHFLIGLVGATLNGAIMPVFSIIFS 833
Query: 1641 RTYEGFAMIGEDML-YYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFS 1465
F D L S AL F+ LAV L + Q Y F + E+L+ LR SF
Sbjct: 834 EILGIFQEQDTDELTRRSRNMALWFILLAVVAALANFIQIYCFTFIGEKLTFNLRRLSFE 893
Query: 1464 HMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYC 1285
++ ++D +S RL+ L T+++ V+ RLG +I +V I + A +
Sbjct: 894 SIMRQDIGWFDLTENSTGRLTANLATEATLVQGMTSQRLGLLIQNIVTIVAGLVIAFVSG 953
Query: 1284 WKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLED 1105
WK+TL VL P Q+ A+ + A EA+ +RTV + E+
Sbjct: 954 WKLTLVVLACVPVIGFAGKVEMDFFQGFSQKGKEAYAECGQVASEAIGGIRTVSSFTCEN 1013
Query: 1104 KIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKE----VA 937
KI+ + LQK + F+++ + G + G S F+Y++++ +G L E +
Sbjct: 1014 KILEKFRQCLQKPIQMSFRKSNVSGLSFGFSQCTLFFIYTLTYWYGGKLVDSGEWPAKES 1073
Query: 936 PMDTYL-------------------------------VLMTLSMTANMAGSAAAYLPDYK 850
++TY V + M+A G + A++PD
Sbjct: 1074 TLETYCYNGEYANIGYTDEATCIKSFTTTEGFSMMMRVFFAIIMSAMGVGQSMAFMPDLG 1133
Query: 849 KAVHAAGLIFHLFTYPATM-PFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLK 673
KA AA IF L + + PF + KG+I ++++F Y RP++ + G NL
Sbjct: 1134 KAKLAAVAIFSLIDRVSEIDPFENKGQTLPEFKGDIEFKDIKFSYPSRPNKAVFQGFNLV 1193
Query: 672 VDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQE 493
+ GK +ALVG SG GKS++ISLLERFY+ G + ID N++D+NLN LR N+ LV QE
Sbjct: 1194 IPHGKKVALVGNSGGGKSSVISLLERFYNPSQGSITIDGVNIKDLNLNWLRGNMGLVGQE 1253
Query: 492 PTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQ 313
P LF+ +I EN++YG + E+ +A + ANA F+ P T +G++ QLSGGQ
Sbjct: 1254 PFLFSGTIFENIIYGKPDATMD-EVVEAAKAANAHTFIESLPDAYHTQLGDKFTQLSGGQ 1312
Query: 312 KQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNA 133
KQR+AIARAI+RNPKVLLLDEATSALD+ SEKVVQ ALD S+ +++V+AHRLSTV++A
Sbjct: 1313 KQRVAIARAIIRNPKVLLLDEATSALDTVSEKVVQVALDNVSKGRTSIVIAHRLSTVIDA 1372
Query: 132 DSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
D I V+K GKV E GTHE LL + Y LV +Q
Sbjct: 1373 DLIVVVKEGKVVELGTHETLLAENGFYAELVSRQ 1406
Score = 259 bits (662), Expect = 3e-67
Identities = 126/244 (51%), Positives = 183/244 (74%)
Frame = -1
Query: 2667 EVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNI 2488
E G+I FK++KFSYP+RP+ V +G + + +G+ +ALVG SG GKS+V+ LL +YN
Sbjct: 1164 EFKGDIEFKDIKFSYPSRPNKAVFQGFNLVIPHGKKVALVGNSGGGKSSVISLLERFYNP 1223
Query: 2487 DSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRK 2308
G+I IDG+++ D+N+ LR +G+V QEP LF+ TI ENI +G P+ ++ E+ A +
Sbjct: 1224 SQGSITIDGVNIKDLNLNWLRGNMGLVGQEPFLFSGTIFENIIYGKPDATMDEVVEAAKA 1283
Query: 2307 ANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESE 2128
ANA+ F+ S P T +G++ TQLSGGQKQR+AIAR ++RNPK+LLLDEATSALD SE
Sbjct: 1284 ANAHTFIESLPDAYHTQLGDKFTQLSGGQKQRVAIARAIIRNPKVLLLDEATSALDTVSE 1343
Query: 2127 QVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLV 1948
+VVQ AL+N S+GRT+IV+AHRLST+ +A I+V+++G++VE+G H+ L+A+ G Y +LV
Sbjct: 1344 KVVQVALDNVSKGRTSIVIAHRLSTVIDADLIVVVKEGKVVELGTHETLLAENGFYAELV 1403
Query: 1947 QAQL 1936
Q+
Sbjct: 1404 SRQM 1407
>gi|12643301|sp|O95342|AB11_HUMAN Bile salt export pump (ATP-binding
cassette, sub-family B, member 11)
gi|3873243|gb|AAC77455.1| bile salt export pump [Homo sapiens]
Length = 1321
Score = 674 bits (1738), Expect = 0.0
Identities = 432/1280 (33%), Positives = 668/1280 (51%), Gaps = 83/1280 (6%)
Frame = -1
Query: 3630 DEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITN 3451
DEKK + +F+ SS + +L +G L + + G QP + FG ++ V +
Sbjct: 36 DEKKGDGVRVGFFQLFRFSSSTDIWLMFVGSLCAFLHGIAQPGVLLIFGTMTDVFIDYDV 95
Query: 3450 AINNKTID-PADLEKAYEEYERGMNQVVFHFFLCG-----------CAYFIFASLQHAIM 3307
+ I A + +NQ + + CG +Y+ ++ I
Sbjct: 96 ELQELQIPGKACVNNTIVWTNSSLNQNMTNGTRCGLLNIESEMIKFASYYAGIAVAVLIT 155
Query: 3306 KYV--------GDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNE 3151
Y+ ++RK Y R+++ + +FD S G L+T +D++ + + +
Sbjct: 156 GYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIAD 215
Query: 3150 KIALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYA 2971
++AL I +T G L F+ W+L I S I V K T + YA
Sbjct: 216 QMALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYA 275
Query: 2970 NAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNS 2791
AG +A + + + +TV + G+K E+ERY + L +++GIR+ ++ G +
Sbjct: 276 KAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFL 335
Query: 2790 LNTVVLYVGATMIYS------GTLET---AVVVRDDNV---------------------- 2704
V + G+T++ GTL +V+V N+
Sbjct: 336 CYAVAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIFE 395
Query: 2703 -IEK-------DETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALV 2548
I++ E Y ++ + G I F NV F YP+RP+ ++L ++ ++ GE ALV
Sbjct: 396 TIDRKPIIDCMSEDGYKLD-RIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALV 454
Query: 2547 GASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEE 2368
G SG+GKST +QL+ +Y+ G + +DG D+ +NI+ LR IG+V QEPVLF+TTI E
Sbjct: 455 GPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAE 514
Query: 2367 NIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLV 2188
NIR+G + ++ +I A ++ANAY+F+ P+ T+VGE G Q+SGGQKQR+AIAR L+
Sbjct: 515 NIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALI 574
Query: 2187 RNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEI 2008
RNPKILLLD ATSALDNESE +VQ+ L G T I VAHRLST+R A II + G
Sbjct: 575 RNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTA 634
Query: 2007 VEVGNHDELIAKRGVYNDLVQAQLLESHDDHEE------LPPLAARQLSQ--ELSPLHSY 1852
VE G H+EL+ ++GVY LV Q + +EE + AR S+ L +
Sbjct: 635 VERGTHEELLERKGVYFTLVTLQSQGNQALNEEDIKDATEDDMLARTFSRGSYQDSLRAS 694
Query: 1851 AIQRSTSNDAGVHDDDMERILDELS-------------KEGAKKSNLREIVKQCRPDYCF 1711
QRS S + + + ++D S +E + + +R I+K P++ +
Sbjct: 695 IRQRSKSQLSYLVHEPPLAVVDHKSTYEEDRKDKDIPVQEEVEPAPVRRILKFSAPEWPY 754
Query: 1710 LFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIG-EDMLYYSHLWALSFMFLAVFRPLTLY 1534
+ + G+A+ G P+ A L + F++ E+ + L F+ + T +
Sbjct: 755 MLVGSVGAAVNGTVTPLYAFLFSQILGTFSIPDKEEQRSQINGVCLLFVAMGCVSLFTQF 814
Query: 1533 CQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDD 1354
Q Y F K E L+ RLR F ML A++DD +S L+ RL TD+S V+ A
Sbjct: 815 LQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTTRLATDASQVQGAAGS 874
Query: 1353 RLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFE 1174
++G ++ + +++A+ A + WK++L +L FFP D A E
Sbjct: 875 QIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQTRMLTGFASRDKQALE 934
Query: 1173 NSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLF 994
+ EAL N+RTV + E + + + L+K K+ ++A I G +
Sbjct: 935 MVGQITNEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKANIYGFCFAFAQCIMFI 994
Query: 993 VYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHL 814
S S+++G YL + + + V+ + ++A G A +Y P Y KA +A F L
Sbjct: 995 ANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRAFSYTPSYAKAKISAARFFQL 1054
Query: 813 F-TYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGP 637
P ++++ K + +G+I + +F Y RPD +LNG+++ + PG+TLA VG
Sbjct: 1055 LDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGS 1114
Query: 636 SGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENL 457
SGCGKST I LLERFY G+V ID + + +N+ LRSN+ +VSQEP LF CSI +N+
Sbjct: 1115 SGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNI 1174
Query: 456 LYG-LTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAIL 280
YG T+ +P + A + A +FV P+ +T VG +G+QLS G+KQRIAIARAI+
Sbjct: 1175 KYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIV 1234
Query: 279 RNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKV 100
R+PK+LLLDEATSALD++SEK VQ ALD A E + +V+AHRLST+ NAD IAV+ G V
Sbjct: 1235 RDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVV 1294
Query: 99 AEQGTHEELLRKRSIYWRLV 40
E+GTHEEL+ ++ Y++LV
Sbjct: 1295 IEKGTHEELMAQKGAYYKLV 1314
Score = 290 bits (741), Expect = 2e-76
Identities = 202/606 (33%), Positives = 306/606 (50%), Gaps = 41/606 (6%)
Frame = -1
Query: 3642 LPQSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLV 3463
+P +E +P+ + R + K S+ ++ L+G + + + G P ++ F SQ+L
Sbjct: 730 IPVQEEVEPAPV----RRILKFSAPEWPYM-LVGSVGAAVNGTVTPLYAFLF---SQILG 781
Query: 3462 TITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTT 3283
T + I +K EE +N V F GC LQ G+ T
Sbjct: 782 TFS--IPDK-----------EEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLT 828
Query: 3282 YRVRKQYISRLLKKDAQYFDSV--STGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTL 3109
R+RK +L +D +FD + S G L+T L + + + +I +I+ T+ T+
Sbjct: 829 KRLRKFGFRAMLGQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTV 888
Query: 3108 GTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYK 2929
+AF W+L+ + F +A SG + + + G I + L +
Sbjct: 889 AMIIAFSFSWKLSLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIR 948
Query: 2928 TVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIY 2749
TV + ++ IE EL+ K I++A +Y N+ G +I
Sbjct: 949 TVAGIGKERRFIEALETELEKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLIS 1008
Query: 2748 SGTLETAVVVRDDNVIEKDET--------------------------DYDVEVEV----- 2662
+ L + V R + + T D + V
Sbjct: 1009 NEGLHFSYVFRVISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAG 1068
Query: 2661 ------NGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLH 2500
G I F + KF+YP+RPD+QVL G+S + G+ +A VG+SG GKST +QLL
Sbjct: 1069 EKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLER 1128
Query: 2499 YYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLP--EI 2326
+Y+ D G + IDG D +N++ LR IG+VSQEPVLF +I +NI++G+ +P +
Sbjct: 1129 FYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERV 1188
Query: 2325 YGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSA 2146
A ++A +DFV S P+ +T VG +G+QLS G+KQRIAIAR +VR+PKILLLDEATSA
Sbjct: 1189 IAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSA 1248
Query: 2145 LDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRG 1966
LD ESE+ VQ AL+ A +GRT IV+AHRLSTI+NA I VM +G ++E G H+EL+A++G
Sbjct: 1249 LDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKG 1308
Query: 1965 VYNDLV 1948
Y LV
Sbjct: 1309 AYYKLV 1314
Score = 289 bits (739), Expect = 4e-76
Identities = 180/546 (32%), Positives = 285/546 (51%), Gaps = 4/546 (0%)
Frame = -1
Query: 1629 GFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSL 1450
G I +M+ ++ +A +AV +T Y Q ++ + + ++R F ++ +
Sbjct: 130 GLLNIESEMIKFASYYA----GIAVAVLITGYIQICFWVIAAARQIQKMRKFYFRRIMRM 185
Query: 1449 PCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTL 1270
++D +S L+ R + D + + A+ D++ I + + WK+TL
Sbjct: 186 EIGWFDC--NSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTL 243
Query: 1269 EVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSL 1090
++ P + A+ + A E + ++RTV A E + +
Sbjct: 244 VIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVER 303
Query: 1089 ISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRK-EVAPMDTYLVL 913
++L + ++ I+ G G Y+V+F +G+ L L + E P +
Sbjct: 304 YEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYAVAFWYGSTLVLDEGEYTPGTLVQIF 363
Query: 912 MTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKK-NIEKGEIIGE 736
+++ + A G+A+ L + AA IF + S DG K + KGEI
Sbjct: 364 LSVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRIKGEIEFH 423
Query: 735 NVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDS 556
NV FHY RP+ ILN +N+ + PG+ ALVGPSG GKST + L++RFY +G V +D
Sbjct: 424 NVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDG 483
Query: 555 ENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVF 376
++ +N+ LR + +V QEP LF+ +I EN+ YG + + ++ +A + ANA+NF+
Sbjct: 484 HDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATME-DIVQAAKEANAYNFIM 542
Query: 375 QFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALD 196
PQ DTLVGE G Q+SGGQKQR+AIARA++RNPK+LLLD ATSALD++SE +VQ L
Sbjct: 543 DLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEVLS 602
Query: 195 TASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLV--QKQGIQ 22
+ + VAHRLSTV AD+I ++G E+GTHEELL ++ +Y+ LV Q QG Q
Sbjct: 603 KIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQSQGNQ 662
Query: 21 VETPSD 4
D
Sbjct: 663 ALNEED 668
>gi|4704820|gb|AAD28285.1| bile salt export pump [Homo sapiens]
Length = 1321
Score = 674 bits (1738), Expect = 0.0
Identities = 432/1280 (33%), Positives = 667/1280 (51%), Gaps = 83/1280 (6%)
Frame = -1
Query: 3630 DEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITN 3451
DEKK + +F+ SS + +L +G L + + G QP + FG ++ V +
Sbjct: 36 DEKKGDGVRVGFFQLFRFSSSTDIWLMFVGSLCAFLHGIAQPGVLLIFGTMTDVFIDYDV 95
Query: 3450 AINNKTID-PADLEKAYEEYERGMNQVVFHFFLCG-----------CAYFIFASLQHAIM 3307
+ I A + +NQ + + CG +Y+ ++ I
Sbjct: 96 ELQELQIPGKACVNNTIVWTNSSLNQNMTNGTRCGLLNIESEMIKFASYYAGIAVAVLIT 155
Query: 3306 KYV--------GDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNE 3151
Y+ ++RK Y R+++ + +FD S G L+T +D++ + + +
Sbjct: 156 GYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIAD 215
Query: 3150 KIALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYA 2971
++AL I +T G L F+ W+L I S I V K T + YA
Sbjct: 216 QMALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYA 275
Query: 2970 NAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTY---FF 2800
AG +A + + + +TV + G+K E+ERY + L +++GIR+ ++ G + F
Sbjct: 276 KAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFL 335
Query: 2799 CNSL-----NTVVL----YVGATMIY---------------------------SGTLETA 2728
C +L +T+VL Y T++ + T
Sbjct: 336 CYALAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIFE 395
Query: 2727 VVVRDDNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALV 2548
+ R + E Y ++ + G I F NV F YP+RP+ ++L ++ ++ GE ALV
Sbjct: 396 TIDRKPIIDCMSEDGYKLD-RIKGEIEFHNVTFHYPSRPEVKILNDLNMAIKPGEMTALV 454
Query: 2547 GASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEE 2368
G SG+GKST +QL+ +Y+ G + +DG D+ +NI+ LR IG+V QEPVLF+TTI E
Sbjct: 455 GPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAE 514
Query: 2367 NIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLV 2188
NIR+G + ++ +I A ++ANAY+F+ P+ T+VGE G Q+SGGQKQR+AIAR L+
Sbjct: 515 NIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALI 574
Query: 2187 RNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEI 2008
RNPKILLLD ATSALDNESE +VQ+ L G T I VAHRLST+R A II + G
Sbjct: 575 RNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTA 634
Query: 2007 VEVGNHDELIAKRGVYNDLVQAQLLESHDDHEE------LPPLAARQLSQ--ELSPLHSY 1852
VE G H+EL+ ++GVY LV Q + +EE + AR S+ L +
Sbjct: 635 VERGTHEELLERKGVYFTLVTLQSQGNQALNEEDIKDATEDDMLARTFSRGSYQDSLRAS 694
Query: 1851 AIQRSTSNDAGVHDDDMERILDELS-------------KEGAKKSNLREIVKQCRPDYCF 1711
QRS S + + + ++D S +E + + +R I+K P++ +
Sbjct: 695 IRQRSKSQLSYLVHEPPLAVVDHKSTYEEDRKDKDIPVQEEVEPAPVRRILKFSAPEWPY 754
Query: 1710 LFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIG-EDMLYYSHLWALSFMFLAVFRPLTLY 1534
+ + G+A+ G P+ A L + F++ E+ + L F+ + T +
Sbjct: 755 MLVGSVGAAVNGTVTPLYAFLFSQILGTFSIPDKEEQRSQINGVCLLFVAMGCVSLFTQF 814
Query: 1533 CQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDD 1354
Q Y F K E L+ RLR F ML A++DD +S L+ RL TD+S V+ A
Sbjct: 815 LQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTTRLATDASQVQGAAGS 874
Query: 1353 RLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFE 1174
++G ++ + +++A+ A + WK++L +L FFP D A E
Sbjct: 875 QIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQTRMLTGFASRDKQALE 934
Query: 1173 NSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLF 994
+ EAL N+RTV + E + + + L+K K+ ++A I G +
Sbjct: 935 MVGQITNEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKANIYGFCFAFAQCIMFI 994
Query: 993 VYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHL 814
S S+++G YL + + + V+ + ++A G A +Y P Y KA +A F L
Sbjct: 995 ANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRAFSYTPSYAKAKISAARFFQL 1054
Query: 813 F-TYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGP 637
P ++++ K + +G+I + +F Y RPD +LNG+++ + PG+TLA VG
Sbjct: 1055 LDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGS 1114
Query: 636 SGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENL 457
SGCGKST I LLERFY G+V ID + + +N+ LRSN+ +VSQEP LF CSI +N+
Sbjct: 1115 SGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNI 1174
Query: 456 LYG-LTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAIL 280
YG T+ +P + A + A +FV P+ +T VG +G+QLS G+KQRIAIARAI+
Sbjct: 1175 KYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIV 1234
Query: 279 RNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKV 100
R+PK+LLLDEATSALD++SEK VQ ALD A E + +V+AHRLST+ NAD IAV+ G V
Sbjct: 1235 RDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVV 1294
Query: 99 AEQGTHEELLRKRSIYWRLV 40
E+GTHEEL+ ++ Y++LV
Sbjct: 1295 IEKGTHEELMAQKGAYYKLV 1314
Score = 290 bits (741), Expect = 2e-76
Identities = 202/606 (33%), Positives = 306/606 (50%), Gaps = 41/606 (6%)
Frame = -1
Query: 3642 LPQSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLV 3463
+P +E +P+ + R + K S+ ++ L+G + + + G P ++ F SQ+L
Sbjct: 730 IPVQEEVEPAPV----RRILKFSAPEWPYM-LVGSVGAAVNGTVTPLYAFLF---SQILG 781
Query: 3462 TITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTT 3283
T + I +K EE +N V F GC LQ G+ T
Sbjct: 782 TFS--IPDK-----------EEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLT 828
Query: 3282 YRVRKQYISRLLKKDAQYFDSV--STGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTL 3109
R+RK +L +D +FD + S G L+T L + + + +I +I+ T+ T+
Sbjct: 829 KRLRKFGFRAMLGQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTV 888
Query: 3108 GTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYK 2929
+AF W+L+ + F +A SG + + + G I + L +
Sbjct: 889 AMIIAFSFSWKLSLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIR 948
Query: 2928 TVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIY 2749
TV + ++ IE EL+ K I++A +Y N+ G +I
Sbjct: 949 TVAGIGKERRFIEALETELEKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLIS 1008
Query: 2748 SGTLETAVVVRDDNVIEKDET--------------------------DYDVEVEV----- 2662
+ L + V R + + T D + V
Sbjct: 1009 NEGLHFSYVFRVISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAG 1068
Query: 2661 ------NGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLH 2500
G I F + KF+YP+RPD+QVL G+S + G+ +A VG+SG GKST +QLL
Sbjct: 1069 EKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLER 1128
Query: 2499 YYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLP--EI 2326
+Y+ D G + IDG D +N++ LR IG+VSQEPVLF +I +NI++G+ +P +
Sbjct: 1129 FYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERV 1188
Query: 2325 YGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSA 2146
A ++A +DFV S P+ +T VG +G+QLS G+KQRIAIAR +VR+PKILLLDEATSA
Sbjct: 1189 IAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSA 1248
Query: 2145 LDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRG 1966
LD ESE+ VQ AL+ A +GRT IV+AHRLSTI+NA I VM +G ++E G H+EL+A++G
Sbjct: 1249 LDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKG 1308
Query: 1965 VYNDLV 1948
Y LV
Sbjct: 1309 AYYKLV 1314
Score = 288 bits (737), Expect = 7e-76
Identities = 179/546 (32%), Positives = 285/546 (51%), Gaps = 4/546 (0%)
Frame = -1
Query: 1629 GFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSL 1450
G I +M+ ++ +A +AV +T Y Q ++ + + ++R F ++ +
Sbjct: 130 GLLNIESEMIKFASYYA----GIAVAVLITGYIQICFWVIAAARQIQKMRKFYFRRIMRM 185
Query: 1449 PCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTL 1270
++D +S L+ R + D + + A+ D++ I + + WK+TL
Sbjct: 186 EIGWFDC--NSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTL 243
Query: 1269 EVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSL 1090
++ P + A+ + A E + ++RTV A E + +
Sbjct: 244 VIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVER 303
Query: 1089 ISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRK-EVAPMDTYLVL 913
++L + ++ I+ G G Y+++F +G+ L L + E P +
Sbjct: 304 YEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYALAFWYGSTLVLDEGEYTPGTLVQIF 363
Query: 912 MTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKK-NIEKGEIIGE 736
+++ + A G+A+ L + AA IF + S DG K + KGEI
Sbjct: 364 LSVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRIKGEIEFH 423
Query: 735 NVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDS 556
NV FHY RP+ ILN +N+ + PG+ ALVGPSG GKST + L++RFY +G V +D
Sbjct: 424 NVTFHYPSRPEVKILNDLNMAIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDG 483
Query: 555 ENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVF 376
++ +N+ LR + +V QEP LF+ +I EN+ YG + + ++ +A + ANA+NF+
Sbjct: 484 HDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATME-DIVQAAKEANAYNFIM 542
Query: 375 QFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALD 196
PQ DTLVGE G Q+SGGQKQR+AIARA++RNPK+LLLD ATSALD++SE +VQ L
Sbjct: 543 DLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEVLS 602
Query: 195 TASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLV--QKQGIQ 22
+ + VAHRLSTV AD+I ++G E+GTHEELL ++ +Y+ LV Q QG Q
Sbjct: 603 KIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQSQGNQ 662
Query: 21 VETPSD 4
D
Sbjct: 663 ALNEED 668
>gi|21536378|ref|NP_003733.2| ATP-binding cassette, sub-family B
(MDR/TAP), member 11; ABC member 16, MDR/TAP subfamily;
progressive familial intrahepatic cholestasis 2; bile
salt export pump [Homo sapiens]
Length = 1321
Score = 673 bits (1737), Expect = 0.0
Identities = 432/1280 (33%), Positives = 667/1280 (51%), Gaps = 83/1280 (6%)
Frame = -1
Query: 3630 DEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITN 3451
DEKK + +F+ SS + +L +G L + + G QP + FG ++ V +
Sbjct: 36 DEKKGDGVRVGFFQLFRFSSSTDIWLMFVGSLCAFLHGIAQPGVLLIFGTMTDVFIDYDV 95
Query: 3450 AINNKTID-PADLEKAYEEYERGMNQVVFHFFLCG-----------CAYFIFASLQHAIM 3307
+ I A + +NQ + + CG +Y+ ++ I
Sbjct: 96 ELQELQIPGKACVNNTIVWTNSSLNQNMTNGTRCGLLNIESEMIKFASYYAGIAVAVLIT 155
Query: 3306 KYV--------GDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNE 3151
Y+ ++RK Y R+++ + +FD S G L+T +D++ + + +
Sbjct: 156 GYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIAD 215
Query: 3150 KIALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYA 2971
++AL I +T G L F+ W+L I S I V K T + YA
Sbjct: 216 QMALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYA 275
Query: 2970 NAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTY---FF 2800
AG +A + + + +TV + G+K E+ERY + L +++GIR+ ++ G + F
Sbjct: 276 KAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFL 335
Query: 2799 CNSL-----NTVVL----YVGATMIY---------------------------SGTLETA 2728
C +L +T+VL Y T++ + T
Sbjct: 336 CYALAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIFE 395
Query: 2727 VVVRDDNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALV 2548
+ R + E Y ++ + G I F NV F YP+RP+ ++L ++ ++ GE ALV
Sbjct: 396 TIDRKPIIDCMSEDGYKLD-RIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALV 454
Query: 2547 GASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEE 2368
G SG+GKST +QL+ +Y+ G + +DG D+ +NI+ LR IG+V QEPVLF+TTI E
Sbjct: 455 GPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAE 514
Query: 2367 NIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLV 2188
NIR+G + ++ +I A ++ANAY+F+ P+ T+VGE G Q+SGGQKQR+AIAR L+
Sbjct: 515 NIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALI 574
Query: 2187 RNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEI 2008
RNPKILLLD ATSALDNESE +VQ+ L G T I VAHRLST+R A II + G
Sbjct: 575 RNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTA 634
Query: 2007 VEVGNHDELIAKRGVYNDLVQAQLLESHDDHEE------LPPLAARQLSQ--ELSPLHSY 1852
VE G H+EL+ ++GVY LV Q + +EE + AR S+ L +
Sbjct: 635 VERGTHEELLERKGVYFTLVTLQSQGNQALNEEDIKDATEDDMLARTFSRGSYQDSLRAS 694
Query: 1851 AIQRSTSNDAGVHDDDMERILDELS-------------KEGAKKSNLREIVKQCRPDYCF 1711
QRS S + + + ++D S +E + + +R I+K P++ +
Sbjct: 695 IRQRSKSQLSYLVHEPPLAVVDHKSTYEEDRKDKDIPVQEEVEPAPVRRILKFSAPEWPY 754
Query: 1710 LFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIG-EDMLYYSHLWALSFMFLAVFRPLTLY 1534
+ + G+A+ G P+ A L + F++ E+ + L F+ + T +
Sbjct: 755 MLVGSVGAAVNGTVTPLYAFLFSQILGTFSIPDKEEQRSQINGVCLLFVAMGCVSLFTQF 814
Query: 1533 CQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDD 1354
Q Y F K E L+ RLR F ML A++DD +S L+ RL TD+S V+ A
Sbjct: 815 LQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTTRLATDASQVQGAAGS 874
Query: 1353 RLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFE 1174
++G ++ + +++A+ A + WK++L +L FFP D A E
Sbjct: 875 QIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQTRMLTGFASRDKQALE 934
Query: 1173 NSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLF 994
+ EAL N+RTV + E + + + L+K K+ ++A I G +
Sbjct: 935 MVGQITNEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKANIYGFCFAFAQCIMFI 994
Query: 993 VYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHL 814
S S+++G YL + + + V+ + ++A G A +Y P Y KA +A F L
Sbjct: 995 ANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRAFSYTPSYAKAKISAARFFQL 1054
Query: 813 F-TYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGP 637
P ++++ K + +G+I + +F Y RPD +LNG+++ + PG+TLA VG
Sbjct: 1055 LDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGS 1114
Query: 636 SGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENL 457
SGCGKST I LLERFY G+V ID + + +N+ LRSN+ +VSQEP LF CSI +N+
Sbjct: 1115 SGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNI 1174
Query: 456 LYG-LTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAIL 280
YG T+ +P + A + A +FV P+ +T VG +G+QLS G+KQRIAIARAI+
Sbjct: 1175 KYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIV 1234
Query: 279 RNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKV 100
R+PK+LLLDEATSALD++SEK VQ ALD A E + +V+AHRLST+ NAD IAV+ G V
Sbjct: 1235 RDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVV 1294
Query: 99 AEQGTHEELLRKRSIYWRLV 40
E+GTHEEL+ ++ Y++LV
Sbjct: 1295 IEKGTHEELMAQKGAYYKLV 1314
Score = 290 bits (741), Expect = 2e-76
Identities = 202/606 (33%), Positives = 306/606 (50%), Gaps = 41/606 (6%)
Frame = -1
Query: 3642 LPQSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLV 3463
+P +E +P+ + R + K S+ ++ L+G + + + G P ++ F SQ+L
Sbjct: 730 IPVQEEVEPAPV----RRILKFSAPEWPYM-LVGSVGAAVNGTVTPLYAFLF---SQILG 781
Query: 3462 TITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTT 3283
T + I +K EE +N V F GC LQ G+ T
Sbjct: 782 TFS--IPDK-----------EEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLT 828
Query: 3282 YRVRKQYISRLLKKDAQYFDSV--STGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTL 3109
R+RK +L +D +FD + S G L+T L + + + +I +I+ T+ T+
Sbjct: 829 KRLRKFGFRAMLGQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTV 888
Query: 3108 GTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYK 2929
+AF W+L+ + F +A SG + + + G I + L +
Sbjct: 889 AMIIAFSFSWKLSLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIR 948
Query: 2928 TVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIY 2749
TV + ++ IE EL+ K I++A +Y N+ G +I
Sbjct: 949 TVAGIGKERRFIEALETELEKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLIS 1008
Query: 2748 SGTLETAVVVRDDNVIEKDET--------------------------DYDVEVEV----- 2662
+ L + V R + + T D + V
Sbjct: 1009 NEGLHFSYVFRVISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAG 1068
Query: 2661 ------NGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLH 2500
G I F + KF+YP+RPD+QVL G+S + G+ +A VG+SG GKST +QLL
Sbjct: 1069 EKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLER 1128
Query: 2499 YYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLP--EI 2326
+Y+ D G + IDG D +N++ LR IG+VSQEPVLF +I +NI++G+ +P +
Sbjct: 1129 FYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERV 1188
Query: 2325 YGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSA 2146
A ++A +DFV S P+ +T VG +G+QLS G+KQRIAIAR +VR+PKILLLDEATSA
Sbjct: 1189 IAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSA 1248
Query: 2145 LDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRG 1966
LD ESE+ VQ AL+ A +GRT IV+AHRLSTI+NA I VM +G ++E G H+EL+A++G
Sbjct: 1249 LDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKG 1308
Query: 1965 VYNDLV 1948
Y LV
Sbjct: 1309 AYYKLV 1314
Score = 288 bits (736), Expect = 9e-76
Identities = 179/546 (32%), Positives = 285/546 (51%), Gaps = 4/546 (0%)
Frame = -1
Query: 1629 GFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSL 1450
G I +M+ ++ +A +AV +T Y Q ++ + + ++R F ++ +
Sbjct: 130 GLLNIESEMIKFASYYA----GIAVAVLITGYIQICFWVIAAARQIQKMRKFYFRRIMRM 185
Query: 1449 PCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTL 1270
++D +S L+ R + D + + A+ D++ I + + WK+TL
Sbjct: 186 EIGWFDC--NSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTL 243
Query: 1269 EVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSL 1090
++ P + A+ + A E + ++RTV A E + +
Sbjct: 244 VIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVER 303
Query: 1089 ISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRK-EVAPMDTYLVL 913
++L + ++ I+ G G Y+++F +G+ L L + E P +
Sbjct: 304 YEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYALAFWYGSTLVLDEGEYTPGTLVQIF 363
Query: 912 MTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKK-NIEKGEIIGE 736
+++ + A G+A+ L + AA IF + S DG K + KGEI
Sbjct: 364 LSVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRIKGEIEFH 423
Query: 735 NVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDS 556
NV FHY RP+ ILN +N+ + PG+ ALVGPSG GKST + L++RFY +G V +D
Sbjct: 424 NVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDG 483
Query: 555 ENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVF 376
++ +N+ LR + +V QEP LF+ +I EN+ YG + + ++ +A + ANA+NF+
Sbjct: 484 HDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATME-DIVQAAKEANAYNFIM 542
Query: 375 QFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALD 196
PQ DTLVGE G Q+SGGQKQR+AIARA++RNPK+LLLD ATSALD++SE +VQ L
Sbjct: 543 DLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEVLS 602
Query: 195 TASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLV--QKQGIQ 22
+ + VAHRLSTV AD+I ++G E+GTHEELL ++ +Y+ LV Q QG Q
Sbjct: 603 KIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQSQGNQ 662
Query: 21 VETPSD 4
D
Sbjct: 663 ALNEED 668
>gi|39587990|emb|CAE57221.1| Hypothetical protein CBG00083
[Caenorhabditis briggsae]
Length = 1301
Score = 672 bits (1733), Expect = 0.0
Identities = 424/1282 (33%), Positives = 683/1282 (53%), Gaps = 83/1282 (6%)
Frame = -1
Query: 3615 SQICSFIRV----VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNA 3448
SQ+ F V +F+ ++ F+ L ++GV+ S+++G QP ++ G ++ VL+ +
Sbjct: 46 SQVLEFKPVSLLQLFRFATPFDYILLIIGVVTSIISGVSQPVLAIISGRLTNVLLVV--- 102
Query: 3447 INNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRK 3268
DP +E++ + V+ F G I Q+ + V ++R
Sbjct: 103 ------DPLS-----KEFKNKAMENVYIFLGLGIFVSINDFCQYMCFQRVCSRMMTQMRN 151
Query: 3267 QYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFY 3088
+YIS +L+++A +FD +G ++T LNDN+ER ++ +K+ ++I ++ ++
Sbjct: 152 RYISSILRQNAGWFDKNLSGTITTRLNDNMERIQDGVGDKLGVLIRGISMVLTSVIISLV 211
Query: 3087 TDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNG 2908
+WRLA + + S + K+TG++ AG+IA ++L +T+ + NG
Sbjct: 212 YEWRLALMMVGLIPVSTICMTLLSRFLEKSTGEELEKVGIAGAIAEESLMGVRTIQAFNG 271
Query: 2907 QKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYSGTLET- 2731
Q+ + +Y + L +G+++ I G+ +F+ + + G ++ G +++
Sbjct: 272 QEEMVAKYEKHLNSGKRHAIIGGFWSGFFGGMFFFWLLAFMGCGILYGGYLLKVGIIKSP 331
Query: 2730 -----------------------------------AVVVRDDNVIEKDETDYDVEV--EV 2662
++ D V + D + V
Sbjct: 332 GDVFIIIMAMLLGAYFLGLISPHLMVLLNARVAAASIYKTIDRVPKIDPYSKAGKKLDRV 391
Query: 2661 NGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDS 2482
G ++F+NV F YPTR +A+VL G+ V+ G +ALVG SG GKST V LL Y +
Sbjct: 392 VGKVTFRNVHFRYPTRKEAKVLNGLDLTVEPGTSVALVGHSGCGKSTSVGLLTRLYEPED 451
Query: 2481 GNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKAN 2302
G++ IDG+D+ D+N+ LR ++G+V QEP+LFN TI N+ GNP+ + ++ + AN
Sbjct: 452 GSVQIDGVDVRDLNMDWLRNIVGIVQQEPILFNDTIHNNLLIGNPDATREKMIEVCKMAN 511
Query: 2301 AYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQV 2122
A+DF+ PKG T++G+ G QLSGGQKQR+AIARTL+R+PKILLLDEATSALD +SE V
Sbjct: 512 AHDFIKKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKILLLDEATSALDAQSESV 571
Query: 2121 VQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQA 1942
VQ AL NA++GRTTI++AHRLSTIR A KI+ +KG IVE GNH EL+A G Y +LV+A
Sbjct: 572 VQSALNNAARGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHGELVALGGRYYNLVKA 631
Query: 1941 QLL-------------ESHDDHEELPPLAARQLSQELS----------------PLHSYA 1849
Q E D E P + RQ+S S HS+
Sbjct: 632 QQFKQDPEDIELEAEQEDQFDEFEKPTMFTRQVSTRSSRSSGRSGSDEFRRGTLANHSFD 691
Query: 1848 IQRSTSNDAGVHDDDME-RILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGV 1672
R S+ D+ ++ + + K+ + +I K +Y ++FI + + I+G+
Sbjct: 692 RFRKPSHVPTAEDEAFALKVKETMEKDEEVTAGYLDIFKNAHGNYGYMFIGLVAALIRGL 751
Query: 1671 SYPILAQLIVRTYEGFAMI--GEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQ 1498
P A L+ +EGF + G M++ + ++ + + F VSE
Sbjct: 752 DLPAFALLLSWVFEGFEFVPYGGKMMHRFVMSVIAHCGVGLGIWFFQTLSTVMFAIVSEN 811
Query: 1497 LSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAI 1318
L R R+ +F ++L A++D+P H+ L RL D +VKA VD R+ VI A+
Sbjct: 812 LGVRFRVDAFRNLLYQDSAYFDNPAHAPGSLITRLAADPPSVKAVVDGRMMQVIYAFSAV 871
Query: 1317 SIAITTASLYCWKMTL--EVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEAL 1144
+T +YCW++ + L+FF + + + +++ + AIE +
Sbjct: 872 VACVTIGFIYCWQVAILGTSLIFF---LGFVMCGLAFKITILAVEHMQNDDAGKVAIEII 928
Query: 1143 ENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLS------LSCFLFVYSV 982
ENV+T++ L + ++ +K + ++++ + ++ +SCF F ++
Sbjct: 929 ENVKTIQLLTRTKRFLNSYENESKKRKTTELRKSVFEAINYSITQNFMYYMSCFCFALAI 988
Query: 981 SFKFGTYLALRKEVAPMD-TYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTY 805
+ + P+D T+ LM + + +A + P + A AAG +F+L Y
Sbjct: 989 R-------VINEGDQPVDKTFRSLMAMMLCCEGIILSAQFFPQFVGAKSAAGQMFNLI-Y 1040
Query: 804 PATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCG 625
G + +G I+ ENV+F Y QRP + ++ + G+T+A+VGPSG G
Sbjct: 1041 RKPQTGDVKTGSQPEIRGNILFENVKFSYPQRPHQPVMKTLQWTALRGQTVAIVGPSGSG 1100
Query: 624 KSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGL 445
KST IS+LERFY G ++ID +++ ++L HLR+ +ALV QEP LF +IREN+ GL
Sbjct: 1101 KSTCISMLERFYDVTGGALRIDGQDIRTMSLYHLRTQMALVGQEPRLFVGTIRENICLGL 1160
Query: 444 TRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKV 265
+ VP ++ +AL+ ANA F+ P G+DT VGERG QLSGGQKQRIAIARA++R+PK+
Sbjct: 1161 -KDVPLEKINQALELANANRFLGNLPAGIDTEVGERGGQLSGGQKQRIAIARALVRDPKI 1219
Query: 264 LLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGT 85
LLLDEATSALDS+SEK VQ ALD A E + + +AHRLS++ N+D I + +G+V E GT
Sbjct: 1220 LLLDEATSALDSESEKAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDDGRVQEAGT 1279
Query: 84 HEELLRKRSIYWRLVQKQGIQV 19
H EL+ + Y+ L++KQ + +
Sbjct: 1280 HNELMHMKGKYFELIKKQDLAI 1301
Score = 308 bits (789), Expect = 6e-82
Identities = 200/597 (33%), Positives = 321/597 (53%), Gaps = 10/597 (1%)
Frame = -1
Query: 1764 KKSNLREIVKQCRP-DYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMI---GEDMLY 1597
K +L ++ + P DY L I V S I GVS P+LA + R ++ ++
Sbjct: 52 KPVSLLQLFRFATPFDYILLIIGVVTSIISGVSQPVLAIISGRLTNVLLVVDPLSKEFKN 111
Query: 1596 YSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHS 1417
+ F+ L +F + +CQY F +V ++ T++R + S +L ++D N S
Sbjct: 112 KAMENVYIFLGLGIFVSINDFCQYMCFQRVCSRMMTQMRNRYISSILRQNAGWFDK-NLS 170
Query: 1416 ATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXX 1237
T ++ RLN + ++ V D+LG +I + + ++ + +Y W++ L ++ P
Sbjct: 171 GT-ITTRLNDNMERIQDGVGDKLGVLIRGISMVLTSVIISLVYEWRLALMMVGLIPVSTI 229
Query: 1236 XXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKS 1057
+ E+ + A E+L VRT++A N ++++++ +HL S
Sbjct: 230 CMTLLSRFLEKSTGEELEKVGIAGAIAEESLMGVRTIQAFNGQEEMVAKYEKHLN----S 285
Query: 1056 YFKRAIIQGAANGLSLSCFLF----VYSVSFKFGTYLALRKEV-APMDTYLVLMTLSMTA 892
+ AII G +G F F +G YL + +P D ++++M + + A
Sbjct: 286 GKRHAIIGGFWSGFFGGMFFFWLLAFMGCGILYGGYLLKVGIIKSPGDVFIIIMAMLLGA 345
Query: 891 NMAGSAAAYLPDYKKAVHAAGLIFHLFT-YPATMPFSSSDGKKNIEKGEIIGENVQFHYD 715
G + +L A AA I+ P P+S + K + G++ NV F Y
Sbjct: 346 YFLGLISPHLMVLLNARVAAASIYKTIDRVPKIDPYSKAGKKLDRVVGKVTFRNVHFRYP 405
Query: 714 QRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDIN 535
R + +LNG++L V+PG ++ALVG SGCGKST + LL R Y DG V+ID +V D+N
Sbjct: 406 TRKEAKVLNGLDLTVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEDGSVQIDGVDVRDLN 465
Query: 534 LNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLD 355
++ LR+ + +V QEP LFN +I NLL G + + +E + ANA +F+ + P+G D
Sbjct: 466 MDWLRNIVGIVQQEPILFNDTIHNNLLIGNPDATREKMIE-VCKMANAHDFIKKMPKGYD 524
Query: 354 TLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLS 175
TL+G+ G QLSGGQKQR+AIAR ++R+PK+LLLDEATSALD+ SE VVQ+AL+ A+ +
Sbjct: 525 TLIGDGGVQLSGGQKQRVAIARTLIRDPKILLLDEATSALDAQSESVVQSALNNAARGRT 584
Query: 174 TVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQVETPSD 4
T+++AHRLST+ AD I + G + E G H EL+ Y+ LV+ Q + + P D
Sbjct: 585 TIMIAHRLSTIREADKIVFFEKGVIVEAGNHGELVALGGRYYNLVKAQQFK-QDPED 640
>gi|393116|gb|AAA93553.1| P-glycoprotein 5
Length = 1301
Score = 671 bits (1730), Expect = 0.0
Identities = 446/1293 (34%), Positives = 671/1293 (51%), Gaps = 82/1293 (6%)
Frame = -1
Query: 3663 NNFSTPLLPQSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFG 3484
N S Q E K S I +FK S + L ++G++ S+ G QP M G
Sbjct: 19 NEISAKKKMQETEGKVSVI-----KLFKYSDWIDMILLVVGLISSIGNGVMQPLMMLLMG 73
Query: 3483 EVSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMK 3304
++ + +N ID E + N+VV G Y + + + +
Sbjct: 74 DMVNSYIYTPG--DNTIIDEEVNHMIVEGVKESENKVVVKN---GIYYEVISMVLSFLRT 128
Query: 3303 Y----VGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALI 3136
+ V RVR+ Y LL++DA ++D +G L+ + +++ +++ K +I
Sbjct: 129 FSLFVVSQREGIRVRRLYFKSLLRQDATWYDFQESGELTARIATDIKNYQDGIGPKFGMI 188
Query: 3135 IAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSI 2956
++ G + F W LA + +FS I MK K + AG+I
Sbjct: 189 FQIISMVITGCVIEFKKCWDLALVVLATVPFSSFSFTIFQIIGMKYETKALKVFGAAGAI 248
Query: 2955 AFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKY-GIR-RALMYSISRGVTYFFCNSLNT 2782
A +T+G +TV SLN + I Y E++K E + GI+ + LM I V FF +
Sbjct: 249 AEETIGNIRTVQSLNQKNEFIAEYQEKIKQNEHFNGIKGQCLMSWIRFSVITFFMIASYA 308
Query: 2781 VVLYVGATMIYS-----GTLETAVVVRDDNVIEKDET----------------------- 2686
+ + G+ +I G V+ +V+ +T
Sbjct: 309 LGSWYGSLVIRGKGGSKGVFAGHVLTVFLSVLSASQTLSMIAILLNLLFSDKASAYKIFT 368
Query: 2685 ------DYDVE-------VEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVG 2545
D D + E NGNI F +V+F YPTRP VLKG+ +++ GE IALVG
Sbjct: 369 TIDRIPDIDCQSIGGECPTECNGNIRFVDVQFVYPTRPSHHVLKGLDIEIKKGETIALVG 428
Query: 2544 ASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEEN 2365
ASG GKST +QL+ Y + G + +DG D+ ++NIK LR IG+V QE VLF+ TI EN
Sbjct: 429 ASGCGKSTTIQLIQRNYEPNGGRVTLDGKDIRELNIKWLRNQIGLVGQESVLFSGTIREN 488
Query: 2364 IRFG---NPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIART 2194
I G +S E+ + ANAY+FV +G T++GE+G LSGGQKQRIAIAR
Sbjct: 489 IMLGAKEGETLSKDEMIECAKVANAYEFVSKLAEGYDTLIGEKGALLSGGQKQRIAIARA 548
Query: 2193 LVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKG 2014
L+RNP ILLLDEATSALD +SE++VQ+ALE AS+GRTTI+VAHRL+T+RNA +I V +G
Sbjct: 549 LIRNPSILLLDEATSALDTQSEKIVQEALEKASKGRTTIIVAHRLTTVRNADQICVFHQG 608
Query: 2013 EIVEVGNHDELIAKRGVYNDLVQAQLLESHDDHEELPPLAARQLSQELSPLHSYAIQRST 1834
EI+E G H ELI +G Y LV+ Q +E + E + + QE + + ++
Sbjct: 609 EIIEQGKHQELIDLKGTYYGLVKGQSMEEEVEQETVENDIKKFRKQEDKEVENIIVEE-- 666
Query: 1833 SNDAGVHDDDMERILDELSKEG--AKKSN----LREIVKQCRPDYCFLFIAVFGSAIQGV 1672
S+D +D + +I +E KE KK N +R +++Q R ++ +A G + G
Sbjct: 667 SHDEEEEEDIVSKIKEEYEKEKKIRKKRNRFSIIRIMIEQLRMNFVLFILATIGGIVGGA 726
Query: 1671 SYPI-------LAQLIVRTYEGFAMIGEDM--LYYSHLWALSFMFLAVFRPLTLYCQYYY 1519
+PI L +++ +G + E L + +W + F + L+ YC
Sbjct: 727 VFPIFTIKFIDLIVMMMELQDGVELTDEQQHTLVNTIIWVMGIAFAGL---LSTYCYIGI 783
Query: 1518 FGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCV 1339
F +E L +R + F ++ ++D + L RL++D + + LG +
Sbjct: 784 FASSAEYLIGSVRRRMFKSIVKQEIGWFDRKENRVGSLVTRLSSDPTKLNGITGVILGHI 843
Query: 1338 IMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRT 1159
+ + I A A Y WK+ L V+ FP A+E S T
Sbjct: 844 VYILSTICFAFGFALYYDWKLALCVIAVFPIHTLILFFDFKLNSMQSSPAEKAYEESGIT 903
Query: 1158 AIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVS 979
+EA+E+++TV++L E+ + S +L+K +KS FK +I N ++ V +
Sbjct: 904 LVEAVESMKTVQSLTREEYFLKQYSLNLKKPYKSIFKWGLILALVNAITNLSNFIVDAYG 963
Query: 978 FKFGTYLALRK----------EVAPMDTYL----VLMTLSMTANMAGSAAAYLPDYKKAV 841
+ GTYL + MD Y+ +M++ A+ G+ +PD K++
Sbjct: 964 YYLGTYLLAKNLNYTQTNQGFYQEFMDRYMKIQKAIMSVVFAAHGVGNFGEIIPDIGKSM 1023
Query: 840 HAAGLIFHLFTYPATMPFSSSDGKK-NIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDP 664
AA ++L A + S +G N KGEI +N++F Y R D +L G++ K D
Sbjct: 1024 KAARHSYNLIDRNAKIDSSEINGNTFNDVKGEIEFKNIRFRYPTRADNEVLKGISFKADQ 1083
Query: 663 GKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTL 484
GKT+ALVG SGCGKST I L+ERFY GEV +D N++D+N+ LR+ + LV QEP L
Sbjct: 1084 GKTIALVGASGCGKSTTIQLVERFYDPTSGEVLLDGYNIKDLNVKFLRNQIGLVGQEPVL 1143
Query: 483 FNCSIRENLLYGLTR--SVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQK 310
F S+ +N+ G+ V ++ A + ANA +F+ P+G +T+VG+RG+QLSGGQK
Sbjct: 1144 FAESVIDNIKRGVPEGVEVSNEQIYAAAKMANAHDFISAMPEGYNTMVGDRGSQLSGGQK 1203
Query: 309 QRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNAD 130
QRIAIARA++RNPKVLLLDEATSALD+ SEK+VQ+ALD AS+ +T+++AHRLST+ NAD
Sbjct: 1204 QRIAIARALIRNPKVLLLDEATSALDTQSEKIVQDALDKASKGRTTIIIAHRLSTIQNAD 1263
Query: 129 SIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
I V+ GK+ EQGTH+EL+ + Y+ L +Q
Sbjct: 1264 QICVIMRGKIVEQGTHQELMDLKGFYYTLAMQQ 1296
Score = 268 bits (684), Expect = 9e-70
Identities = 176/537 (32%), Positives = 282/537 (51%), Gaps = 15/537 (2%)
Frame = -1
Query: 1569 MFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLN 1390
M L+ R +L+ VS++ R+R F +L +YD + L+ R+
Sbjct: 121 MVLSFLRTFSLFV-------VSQREGIRVRRLYFKSLLRQDATWYDF--QESGELTARIA 171
Query: 1389 TDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXX 1210
TD N + + + G + + + CW + L VL P
Sbjct: 172 TDIKNYQDGIGPKFGMIFQIISMVITGCVIEFKKCWDLALVVLATVPFSSFSFTIFQIIG 231
Query: 1209 XXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKS-YFKRAIIQ 1033
+ F + A E + N+RTV++LN +++ I+E+ +KI ++ +F Q
Sbjct: 232 MKYETKALKVFGAAGAIAEETIGNIRTVQSLNQKNEF---IAEYQEKIKQNEHFNGIKGQ 288
Query: 1032 GAANGLSLSCFLFVYSVSFKFGTY---LALRKEVAP--------MDTYLVLMTLSMTANM 886
+ + S F S+ G++ L +R + + +L +++ S T +M
Sbjct: 289 CLMSWIRFSVITFFMIASYALGSWYGSLVIRGKGGSKGVFAGHVLTVFLSVLSASQTLSM 348
Query: 885 AGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIE-KGEIIGENVQFHYDQR 709
L K + + IF + S G+ E G I +VQF Y R
Sbjct: 349 IAILLNLLFSDKASAYK---IFTTIDRIPDIDCQSIGGECPTECNGNIRFVDVQFVYPTR 405
Query: 708 PDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLN 529
P +L G+++++ G+T+ALVG SGCGKST I L++R Y G V +D +++ ++N+
Sbjct: 406 PSHHVLKGLDIEIKKGETIALVGASGCGKSTTIQLIQRNYEPNGGRVTLDGKDIRELNIK 465
Query: 528 HLRSNLALVSQEPTLFNCSIRENLLYGLTR--SVPQLELEKALQTANAFNFVFQFPQGLD 355
LR+ + LV QE LF+ +IREN++ G ++ + E+ + + ANA+ FV + +G D
Sbjct: 466 WLRNQIGLVGQESVLFSGTIRENIMLGAKEGETLSKDEMIECAKVANAYEFVSKLAEGYD 525
Query: 354 TLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLS 175
TL+GE+GA LSGGQKQRIAIARA++RNP +LLLDEATSALD+ SEK+VQ AL+ AS+ +
Sbjct: 526 TLIGEKGALLSGGQKQRIAIARALIRNPSILLLDEATSALDTQSEKIVQEALEKASKGRT 585
Query: 174 TVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQVETPSD 4
T++VAHRL+TV NAD I V G++ EQG H+EL+ + Y+ LV+ Q ++ E +
Sbjct: 586 TIIVAHRLTTVRNADQICVFHQGEIIEQGKHQELIDLKGTYYGLVKGQSMEEEVEQE 642
>gi|22535563|dbj|BAC10738.1| putative multidrug resistance protein 1
homolog [Oryza sativa (japonica cultivar-group)]
gi|27368857|emb|CAD59586.1| MDR-like ABC transporter [Oryza sativa
(japonica cultivar-group)]
Length = 1274
Score = 669 bits (1727), Expect = 0.0
Identities = 413/1249 (33%), Positives = 644/1249 (51%), Gaps = 65/1249 (5%)
Frame = -1
Query: 3588 VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEK 3409
+F+ + + L +G + +L G QP M+ FG+V TN
Sbjct: 42 LFRYADGTDLLLMAVGTVAALANGVSQPLMTVIFGQVINAFGEATNG------------- 88
Query: 3408 AYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQY 3229
+ +NQ V +F G A + + LQ A G+ R+R Y+ +L++D +
Sbjct: 89 ---DVLHRVNQAVLNFVYLGIATAVVSFLQVACWTMTGERQATRIRSLYLKSVLRQDIAF 145
Query: 3228 FD-SVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFF 3052
FD ++TG + + ++ + ++ EK+ + V F G +AF W L+ +
Sbjct: 146 FDVEMTTGQIVSRMSGDTVLVQDAIGEKVGKFLQLVATFAGGFVVAFVKGWLLSLVMLAC 205
Query: 3051 SLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEEL 2872
+ +G S + K + K Y++A ++ QT+GA KTV S NG+K + Y + +
Sbjct: 206 IPPVVIAGGAVSKMLAKISSKGQASYSDAANVVEQTIGAIKTVVSFNGEKQAVASYNKLI 265
Query: 2871 KAGEKYGIRRALMYSISRGVTYF-FCNSLNTVVLYVGATMI---YSG------------- 2743
K + L G +F F +S + Y G ++ YSG
Sbjct: 266 NKAYKAAVEEGLTNGFGMGSVFFIFFSSYGLAIWYGGKLVVSKGYSGGDIINILFAVMTG 325
Query: 2742 --TLETAV-------------------VVRDDNVIEKDETDYDVEVEVNGNISFKNVKFS 2626
+L A + R + D T +E ++ G++ K+V FS
Sbjct: 326 AMSLGNATPCMAAFAEGQSAAYRLFKTIKRKPQIDPDDITGKQLE-DIRGDVELKDVYFS 384
Query: 2625 YPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLND 2446
YP RP+ + G S V +G +A+VG SGSGKSTV+ L+ +Y+ +G + IDG+++
Sbjct: 385 YPARPEQLIFDGFSLHVSSGTTMAIVGESGSGKSTVISLVERFYDPQAGEVLIDGINIKS 444
Query: 2445 MNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGI 2266
+ + +R IG+VSQEP+LF T+I++NI +G + ++ EI A ANA +F+ P G
Sbjct: 445 LRLNWIRGKIGLVSQEPLLFMTSIKDNITYGKEDATIEEIRRAAELANAANFIDKLPDGY 504
Query: 2265 KTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGR 2086
T+VG+RG QLSGGQKQRIAIAR +++NPKILLLDEATSALD ESE++VQ+AL R
Sbjct: 505 DTMVGQRGAQLSGGQKQRIAIARAILKNPKILLLDEATSALDVESERIVQEALNRIMVDR 564
Query: 2085 TTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAK-RGVYNDLVQAQLLESHDDHEE 1909
TT+VVAHRL+T+RNA I V+Q+G+IVE G HDEL+ GVY+ L++ Q + HEE
Sbjct: 565 TTLVVAHRLTTVRNADCISVVQQGKIVEQGPHDELVMNPNGVYSQLIRLQ-----ETHEE 619
Query: 1908 LPPLAARQLSQELSPLHSYAIQRSTSNDAGVHD------------------DDMERILDE 1783
+S S S + +RS S D+ + + + + E
Sbjct: 620 EEKKLDHHISDSRSKSRSLSFKRSISRDSAGNSSRHSLALPFGLPGSVELLEGNDSTVGE 679
Query: 1782 LSKEGA-----KKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAM 1618
+++G +K+ + + + +P+ L +A + + GV +P+ +I + F
Sbjct: 680 QTEQGGDGEVQQKAPIGRLARLNKPEVPILLLATLAAGVHGVLFPMFGVMISNAIKTFFE 739
Query: 1617 IGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAF 1438
+ + + W L + L + +++ +Y+ FG +L R+R SF ++ A+
Sbjct: 740 PADKLKKDASFWGLMCVVLGIISIISIPVEYFMFGIAGGKLVERVRALSFRSIIHQEVAW 799
Query: 1437 YDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLM 1258
+DDP +S+ L RL+ D+ NV+ V D L + V + I A + WK+TL +L
Sbjct: 800 FDDPRNSSGALGARLSVDALNVRRLVGDNLALAVQVVSTLITGIVIAMIADWKLTLIILC 859
Query: 1257 FFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEH 1078
P ++ + +E++++ A +A+ ++RTV + E ++M++
Sbjct: 860 VIPLVGLQGYAQVKFLKGFSEDAKMLYEDASQVATDAVSSIRTVASFCSEKRVMTMYDNK 919
Query: 1077 LQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSM 898
+ + ++ G G S Y + F G + D + V L +
Sbjct: 920 CEASKNQGVRTGMVGGLGFGFSFLMLYLTYGLCFYVGAQFVRHNKTTFGDVFKVFFALVL 979
Query: 897 TANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIE-KGEIIGENVQFH 721
+A D KA +A IF L + + SS +G+ KG I +V F
Sbjct: 980 ATIGISQTSAMASDSTKAKDSAISIFALLDRKSQIDSSSDEGRTLANVKGNIDFRHVSFK 1039
Query: 720 YDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVED 541
Y RPD I + L + GKT+ALVG SG GKST I+LLERFY+ G + +D +++
Sbjct: 1040 YPTRPDVQIFSDFTLHIPSGKTVALVGESGSGKSTAIALLERFYNPESGTILLDEVEIKN 1099
Query: 540 INLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQG 361
+ +N LR + LV QEP LFN +IR N+ YG V + EL KA + +NA F+ PQG
Sbjct: 1100 LKVNWLRDQMGLVGQEPVLFNDTIRANIAYGKHGDVTEEELIKAAKASNAHEFISSLPQG 1159
Query: 360 LDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASER 181
DT VGERG QLSGGQKQR+AIARAIL++PK+LLLDEATSALD++SE++VQ+ALD
Sbjct: 1160 YDTTVGERGVQLSGGQKQRVAIARAILKDPKILLLDEATSALDAESERIVQDALDNVMVG 1219
Query: 180 LSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLR-KRSIYWRLVQ 37
+T++VAHRLST+ AD IAVLK+G +AE+G HE L+ K +Y LV+
Sbjct: 1220 RTTIIVAHRLSTIKGADIIAVLKDGAIAEKGRHEALMNIKDGVYASLVE 1268
Score = 301 bits (770), Expect = 1e-79
Identities = 186/571 (32%), Positives = 312/571 (54%), Gaps = 7/571 (1%)
Frame = -1
Query: 1722 DYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFA-MIGEDMLYYSHLWALSFMFLAVFRP 1546
D + + + GVS P++ + + F D+L+ + L+F++L +
Sbjct: 50 DLLLMAVGTVAALANGVSQPLMTVIFGQVINAFGEATNGDVLHRVNQAVLNFVYLGIATA 109
Query: 1545 LTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKA 1366
+ + Q + E+ +TR+R +L AF+ D + ++ +R++ D+ V+
Sbjct: 110 VVSFLQVACWTMTGERQATRIRSLYLKSVLRQDIAFF-DVEMTTGQIVSRMSGDTVLVQD 168
Query: 1365 AVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDT 1186
A+ +++G + V + A + W ++L +L P +
Sbjct: 169 AIGEKVGKFLQLVATFAGGFVVAFVKGWLLSLVMLACIPPVVIAGGAVSKMLAKISSKGQ 228
Query: 1185 IAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLS 1006
++ ++ + + ++TV + N E + ++ + + I+K+Y K A+ +G NG +
Sbjct: 229 ASYSDAANVVEQTIGAIKTVVSFNGEKQ---AVASYNKLINKAY-KAAVEEGLTNGFGMG 284
Query: 1005 CFLFV----YSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVH 838
F+ Y ++ +G L + K + D +L + A G+A + + +
Sbjct: 285 SVFFIFFSSYGLAIWYGGKLVVSKGYSGGDIINILFAVMTGAMSLGNATPCMAAFAEGQS 344
Query: 837 AAGLIFHLFTYPATMPFSSSDGKKNIE-KGEIIGENVQFHYDQRPDRMILNGVNLKVDPG 661
AA +F + GK+ + +G++ ++V F Y RP+++I +G +L V G
Sbjct: 345 AAYRLFKTIKRKPQIDPDDITGKQLEDIRGDVELKDVYFSYPARPEQLIFDGFSLHVSSG 404
Query: 660 KTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLF 481
T+A+VG SG GKST+ISL+ERFY GEV ID N++ + LN +R + LVSQEP LF
Sbjct: 405 TTMAIVGESGSGKSTVISLVERFYDPQAGEVLIDGINIKSLRLNWIRGKIGLVSQEPLLF 464
Query: 480 NCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRI 301
SI++N+ YG + + E+ +A + ANA NF+ + P G DT+VG+RGAQLSGGQKQRI
Sbjct: 465 MTSIKDNITYGKEDATIE-EIRRAAELANAANFIDKLPDGYDTMVGQRGAQLSGGQKQRI 523
Query: 300 AIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIA 121
AIARAIL+NPK+LLLDEATSALD +SE++VQ AL+ +T+VVAHRL+TV NAD I+
Sbjct: 524 AIARAILKNPKILLLDEATSALDVESERIVQEALNRIMVDRTTLVVAHRLTTVRNADCIS 583
Query: 120 VLKNGKVAEQGTHEEL-LRKRSIYWRLVQKQ 31
V++ GK+ EQG H+EL + +Y +L++ Q
Sbjct: 584 VVQQGKIVEQGPHDELVMNPNGVYSQLIRLQ 614
>gi|13929072|ref|NP_113948.1| ATP-binding cassette, sub-family B
(MDR/TAP), member 11; sister of P-glycoprotein; bile salt
export pump [Rattus norvegicus]
gi|12585136|sp|O70127|AB11_RAT Bile salt export pump (ATP-binding
cassette, sub-family B, member 11) (Sister of
P-glycoprotein)
gi|11346285|pir||T42842 bile salt transport protein, ATP-dependent -
rat
gi|3075422|gb|AAC40084.1| bile salt export pump [Rattus norvegicus]
Length = 1321
Score = 666 bits (1719), Expect = 0.0
Identities = 436/1288 (33%), Positives = 663/1288 (50%), Gaps = 91/1288 (7%)
Frame = -1
Query: 3630 DEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLV---- 3463
D+ K I +F+ SS + +L L+G + +L+ G QP + FG ++ + +
Sbjct: 36 DKMKEGDIRVGFFELFRFSSSKDIWLMLMGGVCALLHGMAQPGILIIFGIMTDIFIKYDI 95
Query: 3462 ---------------TIT--------NAINNKTIDPADLEKAYEEYERGMNQVVFHFFLC 3352
TI N N D+E ++ G+ V
Sbjct: 96 ERQELEIPGKACVNNTIVWINSSFHQNMTNGTVCGLVDIESEMIKFS-GIYAGV------ 148
Query: 3351 GCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLER 3172
G I Q + G R+RK Y R+++ + +FD S G L++ D++E+
Sbjct: 149 GMTVLILGYFQIRLWVITGARQIRRMRKIYFRRIMRMEIGWFDCTSVGELNSRFADDIEK 208
Query: 3171 FREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTG 2992
+ +++A + ++ G L FY W+L + S I + + K T
Sbjct: 209 INDAIADQLAHFLQRMSTAMCGLLLGFYRGWKLTLVILAVSPLIGIGAAVIGLSIAKFTE 268
Query: 2991 KQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGV 2812
+ YA AGSIA + L + +TV + G+ E+ERY + L +++GI + ++ G
Sbjct: 269 LELKAYAKAGSIADEVLSSIRTVAAFGGENKEVERYEKNLVFAQRWGIWKGMVMGFFTGY 328
Query: 2811 TY---FFCNSL-----NTVVL----YVGATMIY--------------------------S 2746
+ FFC +L +T+VL Y T++ S
Sbjct: 329 MWCLIFFCYALAFWYGSTLVLDEEEYTPGTLVQIFLCVILAAMNIGHASSCLEIFSTGCS 388
Query: 2745 GTLETAVVVRDDNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNG 2566
+ VI+ D + G I F NV F YP+RPD ++L +S ++ G
Sbjct: 389 AATNIFQTIDRQPVIDCMSGDGYKLDRIKGEIEFHNVTFHYPSRPDVKILDNLSMVIKPG 448
Query: 2565 ECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLF 2386
E ALVG+SG+GKST +QL+ +Y+ G + +DG D+ +NI+ LR IG+V QEPVLF
Sbjct: 449 ETTALVGSSGAGKSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLF 508
Query: 2385 NTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIA 2206
+TTI ENIRFG + ++ +I A + ANAY+F+ + P+ T+VGE G Q+SGGQKQR+A
Sbjct: 509 STTIAENIRFGREDATMEDIVQAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQKQRVA 568
Query: 2205 IARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIV 2026
IAR L+RNPKILLLD ATSALDNESE VQ+AL G T I VAHRLST+R A II
Sbjct: 569 IARALIRNPKILLLDMATSALDNESEARVQEALNKIQHGHTIISVAHRLSTVRAADVIIG 628
Query: 2025 MQKGEIVEVGNHDELIAKRGVYNDLV--QAQLLESHDDHEELPPLAARQLSQELS----- 1867
+ G VE G H+EL+ ++GVY LV Q+Q +H + + A + E +
Sbjct: 629 FEHGVAVERGTHEELLERKGVYFMLVTLQSQGDNAHKETSIMGKDATEGGTLERTFSRGS 688
Query: 1866 ---PLHSYAIQRSTSNDAGVHDDDMERILDELSKEGAKKSN-----------LREIVKQC 1729
L + QRS S + + D + D S K N +R I+K
Sbjct: 689 YRDSLRASIRQRSKSQLSLLTHDPPLAVADHKSSYKDSKDNDVLVEEVEPAPVRRILKYN 748
Query: 1728 RPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIG-EDMLYYSHLWALSFMFLAVF 1552
P++ ++ + +AI G PI + L + F+++ E H L F+ L
Sbjct: 749 IPEWHYILVGSLSAAINGAVTPIYSLLFSQLLGTFSLLDKEQQRSEIHSMCLFFVILGCV 808
Query: 1551 RPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNV 1372
T + Q Y F K E L+ RLR F ML ++DD ++ L+ RL TD+S V
Sbjct: 809 SIFTQFLQGYTFAKSGELLTKRLRKFGFKAMLGQDIGWFDDLRNNPGVLTTRLATDASQV 868
Query: 1371 KAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQE 1192
+ A ++G ++ + I A+ A + WK++L + +FFP +
Sbjct: 869 QGATGSQVGMMVNSFTNIIAALLIAFFFSWKLSLIITIFFPFLALSGAVQTKMLTGFASQ 928
Query: 1191 DTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLS 1012
D A E + + EAL N+RTV + +E + + LQ +K+ ++A I G S
Sbjct: 929 DKQALEKAGQITSEALSNIRTVAGIGVEGRFIKAFEVELQTSYKTAVRKANIYGLCFAFS 988
Query: 1011 LSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAA 832
S ++++G YL + + + V+ +++++A G +Y P Y KA +A
Sbjct: 989 QGIAFLANSAAYRYGGYLIAYEGLGFSHVFRVVSSVALSATAVGRTFSYTPSYAKAKISA 1048
Query: 831 GLIFHLF-TYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKT 655
F L P +S + K + +G+I + +F Y RPD +LNG+++ V+PG+T
Sbjct: 1049 ARFFQLLDRKPPINVYSEAGEKWDNFQGKIDFIDCKFTYPSRPDIQVLNGLSVSVNPGQT 1108
Query: 654 LALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNC 475
LA VG SGCGKST I LLERFY G V ID + + +N+ LRSN+ +VSQEP LF+C
Sbjct: 1109 LAFVGSSGCGKSTSIQLLERFYDPDQGTVMIDGHDSKKVNIQFLRSNIGIVSQEPVLFDC 1168
Query: 474 SIRENLLYGLTRSVPQLELEKAL---QTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQR 304
SI +N+ YG + ++ +E+A+ + A +FV P+ +T VG +G+QLS G+KQR
Sbjct: 1169 SIMDNIKYG--DNTKEISVERAIAAAKQAQLHDFVMSLPEKYETNVGIQGSQLSRGEKQR 1226
Query: 303 IAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSI 124
IAIARAI+R+PK+LLLDEATSALD++SEK VQ ALD A E + +V+AHRLST+ N+D I
Sbjct: 1227 IAIARAIVRDPKILLLDEATSALDTESEKTVQTALDKAREGRTCIVIAHRLSTIQNSDII 1286
Query: 123 AVLKNGKVAEQGTHEELLRKRSIYWRLV 40
AV+ G V E+GTHE+L+ ++ Y++LV
Sbjct: 1287 AVVSQGVVIEKGTHEKLMAQKGAYYKLV 1314
Score = 281 bits (720), Expect = 6e-74
Identities = 179/538 (33%), Positives = 279/538 (51%), Gaps = 4/538 (0%)
Frame = -1
Query: 1629 GFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSL 1450
G I +M+ +S ++A M + + Y Q + + R+R F ++ +
Sbjct: 130 GLVDIESEMIKFSGIYAGVGMTVLILG----YFQIRLWVITGARQIRRMRKIYFRRIMRM 185
Query: 1449 PCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTL 1270
++D S L++R D + A+ D+L + + + WK+TL
Sbjct: 186 EIGWFDCT--SVGELNSRFADDIEKINDAIADQLAHFLQRMSTAMCGLLLGFYRGWKLTL 243
Query: 1269 EVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSL 1090
+L P + + A+ + A E L ++RTV A E+K +
Sbjct: 244 VILAVSPLIGIGAAVIGLSIAKFTELELKAYAKAGSIADEVLSSIRTVAAFGGENKEVER 303
Query: 1089 ISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLAL-RKEVAPMDTYLVL 913
++L + + ++ G G F Y+++F +G+ L L +E P +
Sbjct: 304 YEKNLVFAQRWGIWKGMVMGFFTGYMWCLIFFCYALAFWYGSTLVLDEEEYTPGTLVQIF 363
Query: 912 MTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKK-NIEKGEIIGE 736
+ + + A G A++ L + AA IF + S DG K + KGEI
Sbjct: 364 LCVILAAMNIGHASSCLEIFSTGCSAATNIFQTIDRQPVIDCMSGDGYKLDRIKGEIEFH 423
Query: 735 NVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDS 556
NV FHY RPD IL+ +++ + PG+T ALVG SG GKST + L++RFY +G V +D
Sbjct: 424 NVTFHYPSRPDVKILDNLSMVIKPGETTALVGSSGAGKSTALQLIQRFYDPCEGMVTLDG 483
Query: 555 ENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVF 376
++ +N+ LR + +V QEP LF+ +I EN+ +G + + ++ +A + ANA+NF+
Sbjct: 484 HDIRSLNIRWLRDQIGIVEQEPVLFSTTIAENIRFGREDATME-DIVQAAKDANAYNFIM 542
Query: 375 QFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALD 196
PQ DTLVGE G Q+SGGQKQR+AIARA++RNPK+LLLD ATSALD++SE VQ AL+
Sbjct: 543 ALPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEARVQEALN 602
Query: 195 TASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLV--QKQG 28
+ + VAHRLSTV AD I ++G E+GTHEELL ++ +Y+ LV Q QG
Sbjct: 603 KIQHGHTIISVAHRLSTVRAADVIIGFEHGVAVERGTHEELLERKGVYFMLVTLQSQG 660
>gi|7514034|pir||T42228 P-glycoprotein sister - rat
gi|3273484|gb|AAC24753.1| P-glycoprotein sister [Rattus norvegicus]
Length = 1321
Score = 665 bits (1716), Expect = 0.0
Identities = 436/1288 (33%), Positives = 662/1288 (50%), Gaps = 91/1288 (7%)
Frame = -1
Query: 3630 DEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLV---- 3463
D+ K I +F+ SS + +L L+G + +L+ G QP + FG ++ + +
Sbjct: 36 DKMKEGDIRVGFFELFRFSSSKDIWLMLMGGVCALLHGMAQPGILIIFGIMTDIFIKYDI 95
Query: 3462 ---------------TIT--------NAINNKTIDPADLEKAYEEYERGMNQVVFHFFLC 3352
TI N N D+E ++ G+ V
Sbjct: 96 ERQELEIPGKACVNNTIVWINSSFHQNMTNGTVCGLVDIESEMIKFS-GIYAGV------ 148
Query: 3351 GCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLER 3172
G I Q + G R+RK Y R+++ + +FD S G L++ D++E+
Sbjct: 149 GMTVLILGYFQIRLWVITGARQIRRMRKIYFRRIMRMEIGWFDCTSVGELNSRFADDIEK 208
Query: 3171 FREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTG 2992
+ +++A + ++ G L FY W+L + S I + + K T
Sbjct: 209 INDAIADQLAHFLQRMSTAMCGLLLGFYRGWKLTLVILAVSPLIGIGAAVIGLSIAKFTE 268
Query: 2991 KQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGV 2812
+ YA AGSIA + L + +TV + G+ E+ERY + L +++GI + ++ G
Sbjct: 269 LELKAYAKAGSIADEVLSSIRTVAAFGGENKEVERYEKNLVFAQRWGIWKGMVMGFFTGY 328
Query: 2811 TY---FFCNSL-----NTVVL----YVGATMIY--------------------------S 2746
+ FFC +L +T+VL Y T++ S
Sbjct: 329 MWCLIFFCYALAFWYGSTLVLDEEEYTPGTLVQIFLCVILAAMNIGHASSCLEIFSTGCS 388
Query: 2745 GTLETAVVVRDDNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNG 2566
+ VI+ D + G I F NV F YP+RPD ++L +S ++ G
Sbjct: 389 AATNIFQTIDRQPVIDCMSGDGYKLDRIKGEIEFHNVTFHYPSRPDVKILDNLSMVIKPG 448
Query: 2565 ECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLF 2386
E ALVG+SG+GKST +QL+ +Y+ G + +DG D+ +NI+ LR IG+V QEPVLF
Sbjct: 449 ETTALVGSSGAGKSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLF 508
Query: 2385 NTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIA 2206
+TTI ENIRFG + ++ +I A + ANAY+F+ + P+ T+VGE G Q+SGGQKQR+A
Sbjct: 509 STTIAENIRFGREDATMEDIVQAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQKQRVA 568
Query: 2205 IARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIV 2026
IAR L+RNPKILLLD ATSALDNESE VQ+AL G T I VAHRLST+R A II
Sbjct: 569 IARALIRNPKILLLDMATSALDNESEARVQEALNKIQHGHTIISVAHRLSTVRAADVIIG 628
Query: 2025 MQKGEIVEVGNHDELIAKRGVYNDLV--QAQLLESHDDHEELPPLAARQLSQELS----- 1867
+ G VE G H+EL+ ++GVY LV Q+Q +H + + A + E +
Sbjct: 629 FEHGVAVERGTHEELLERKGVYFMLVTLQSQGDNAHKETSIMGKDATEGGTLERTFSRGS 688
Query: 1866 ---PLHSYAIQRSTSNDAGVHDDDMERILDELSKEGAKKSN-----------LREIVKQC 1729
L + QRS S + + D + D S K N +R I+K
Sbjct: 689 YRDSLRASIRQRSKSQLSLLTHDPPLAVADHKSSYKDSKDNDVLVEEVEPAPVRRILKYN 748
Query: 1728 RPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIG-EDMLYYSHLWALSFMFLAVF 1552
P++ ++ + +AI G PI + L + F+++ E H L F+ L
Sbjct: 749 IPEWHYILVGSLSAAINGAVTPIYSLLFSQLLGTFSLLDKEQQRSEIHSMCLFFVILGCV 808
Query: 1551 RPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNV 1372
T + Q Y F K E L+ RLR F ML ++DD ++ L+ RL TD+S V
Sbjct: 809 SIFTQFLQGYTFAKSGELLTKRLRKFGFKAMLGQDIGWFDDLRNNPGVLTTRLATDASQV 868
Query: 1371 KAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQE 1192
+ A ++G ++ + I A+ A + WK++L + +FFP +
Sbjct: 869 QGATGSQVGMMVNSFTNIIAALLIAFFFSWKLSLIITIFFPFLALSGAVQTKMLTGFASQ 928
Query: 1191 DTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLS 1012
D A E + + EAL N+RTV + +E + + LQ +K+ ++A I G S
Sbjct: 929 DKQALEKAGQITSEALSNIRTVAGIGVEGRFIKAFEVELQTSYKTAVRKANIYGLCFAFS 988
Query: 1011 LSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAA 832
S ++++G YL + + + V+ ++ ++A G +Y P Y KA +A
Sbjct: 989 QGIAFLANSAAYRYGGYLIAYEGLGFSHVFRVVSSVVLSATAVGRTFSYTPSYAKAKISA 1048
Query: 831 GLIFHLF-TYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKT 655
F L P +S + K + +G+I + +F Y RPD +LNG+++ V+PG+T
Sbjct: 1049 ARFFQLLDRKPPINVYSEAGEKWDNFQGKIDFIDCKFTYPSRPDIQVLNGLSVSVNPGQT 1108
Query: 654 LALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNC 475
LA VG SGCGKST I LLERFY G V ID + + +N+ LRSN+ +VSQEP LF+C
Sbjct: 1109 LAFVGSSGCGKSTSIQLLERFYDPDQGTVMIDGHDSKKVNIQFLRSNIGIVSQEPVLFDC 1168
Query: 474 SIRENLLYGLTRSVPQLELEKAL---QTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQR 304
SI +N+ YG + ++ +E+A+ + A +FV P+ +T VG +G+QLS G+KQR
Sbjct: 1169 SIMDNIKYG--DNTKEISVERAIAAAKQAQLHDFVMSLPEKYETNVGIQGSQLSRGEKQR 1226
Query: 303 IAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSI 124
IAIARAI+R+PK+LLLDEATSALD++SEK VQ ALD A E + +V+AHRLST+ N+D I
Sbjct: 1227 IAIARAIVRDPKILLLDEATSALDTESEKTVQTALDKAREGRTCIVIAHRLSTIQNSDII 1286
Query: 123 AVLKNGKVAEQGTHEELLRKRSIYWRLV 40
AV+ G V E+GTHE+L+ ++ Y++LV
Sbjct: 1287 AVVSQGVVIEKGTHEKLMAQKGAYYKLV 1314
Score = 281 bits (720), Expect = 6e-74
Identities = 179/538 (33%), Positives = 279/538 (51%), Gaps = 4/538 (0%)
Frame = -1
Query: 1629 GFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSL 1450
G I +M+ +S ++A M + + Y Q + + R+R F ++ +
Sbjct: 130 GLVDIESEMIKFSGIYAGVGMTVLILG----YFQIRLWVITGARQIRRMRKIYFRRIMRM 185
Query: 1449 PCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTL 1270
++D S L++R D + A+ D+L + + + WK+TL
Sbjct: 186 EIGWFDCT--SVGELNSRFADDIEKINDAIADQLAHFLQRMSTAMCGLLLGFYRGWKLTL 243
Query: 1269 EVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSL 1090
+L P + + A+ + A E L ++RTV A E+K +
Sbjct: 244 VILAVSPLIGIGAAVIGLSIAKFTELELKAYAKAGSIADEVLSSIRTVAAFGGENKEVER 303
Query: 1089 ISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLAL-RKEVAPMDTYLVL 913
++L + + ++ G G F Y+++F +G+ L L +E P +
Sbjct: 304 YEKNLVFAQRWGIWKGMVMGFFTGYMWCLIFFCYALAFWYGSTLVLDEEEYTPGTLVQIF 363
Query: 912 MTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKK-NIEKGEIIGE 736
+ + + A G A++ L + AA IF + S DG K + KGEI
Sbjct: 364 LCVILAAMNIGHASSCLEIFSTGCSAATNIFQTIDRQPVIDCMSGDGYKLDRIKGEIEFH 423
Query: 735 NVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDS 556
NV FHY RPD IL+ +++ + PG+T ALVG SG GKST + L++RFY +G V +D
Sbjct: 424 NVTFHYPSRPDVKILDNLSMVIKPGETTALVGSSGAGKSTALQLIQRFYDPCEGMVTLDG 483
Query: 555 ENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVF 376
++ +N+ LR + +V QEP LF+ +I EN+ +G + + ++ +A + ANA+NF+
Sbjct: 484 HDIRSLNIRWLRDQIGIVEQEPVLFSTTIAENIRFGREDATME-DIVQAAKDANAYNFIM 542
Query: 375 QFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALD 196
PQ DTLVGE G Q+SGGQKQR+AIARA++RNPK+LLLD ATSALD++SE VQ AL+
Sbjct: 543 ALPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEARVQEALN 602
Query: 195 TASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLV--QKQG 28
+ + VAHRLSTV AD I ++G E+GTHEELL ++ +Y+ LV Q QG
Sbjct: 603 KIQHGHTIISVAHRLSTVRAADVIIGFEHGVAVERGTHEELLERKGVYFMLVTLQSQG 660
>gi|39587987|emb|CAE57218.1| Hypothetical protein CBG00078
[Caenorhabditis briggsae]
Length = 1282
Score = 665 bits (1715), Expect = 0.0
Identities = 410/1185 (34%), Positives = 631/1185 (52%), Gaps = 75/1185 (6%)
Frame = -1
Query: 3348 CAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERF 3169
CA S + ++ ++R +Y+ +L+++A +FD +G ++T LND++ER
Sbjct: 105 CAIISGISQPYMCFQHCCSRIMAQMRHRYVYSVLRQNAGWFDKNHSGTIATKLNDSMERI 164
Query: 3168 REVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGK 2989
RE +K+ ++I V +A+ +WRLA + + + + + TT K
Sbjct: 165 REGIGDKLGVLIRGVAMLLASIVVAYIYEWRLACMMLGVAPTCVGCMSLMARQMTATTVK 224
Query: 2988 QNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVT 2809
+ AGSIA ++L +TV + NGQ+ +ERY EL G K+ I + + G+
Sbjct: 225 ELGGVEKAGSIAEESLMGVRTVQAFNGQEEMVERYRVELNKGRKFAIWKGFWSGLYGGLF 284
Query: 2808 YFFCNSLNTVVLYVGATMIYSGTLETA-----------------------------VVVR 2716
+F+ + GA ++ G + + V
Sbjct: 285 FFWLFAFQGCGFLYGAYLLKIGIITSPGDVFIIVMAMLLGSYFLGLISPHLMVLLNARVA 344
Query: 2715 DDNVIEKDETDYDVEV---------EVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGE 2563
++ E E ++ +V G + F+NV F YPTR DA++L G++ ++ G
Sbjct: 345 AASIYETIERVPKIDPYSKKGRFLDKVIGRVKFENVHFRYPTRKDAKILNGLNLTIEPGT 404
Query: 2562 CIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFN 2383
+ALVG SG GKST V LL Y ++GN+ IDG D+ ++NI LR V+G+V QEP+LFN
Sbjct: 405 SVALVGHSGCGKSTSVGLLTRLYEPETGNVTIDGTDVRELNIDYLRNVVGIVQQEPILFN 464
Query: 2382 TTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAI 2203
TI N+ GNPN ++ + ANA+DF+ PKG T++G+ G QLSGGQKQR+AI
Sbjct: 465 DTIHNNLLLGNPNAKREKMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAI 524
Query: 2202 ARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVM 2023
ARTL+R+PK+LLLDEATSALD +SE VVQ AL NAS+GRTTI++AHRLSTIR A I+
Sbjct: 525 ARTLIRDPKVLLLDEATSALDAQSESVVQSALNNASKGRTTIMIAHRLSTIREADMIVFF 584
Query: 2022 QKGEIVEVGNHDELIAKRGVYNDLVQAQLLESHD----------DHEELPPLAARQLSQE 1873
+KG IVE GNH EL+ G Y DLV+AQ + D + +L P A S++
Sbjct: 585 EKGVIVEAGNHAELVRLEGRYYDLVKAQAFKPDDNPISQYDEIAEDIDLGPSATAIHSRQ 644
Query: 1872 LS--------------------PLHSYAIQRSTSNDAGVHDDDMERILDELSKEGAKKSN 1753
S S+A RS++ + E + + ++G +
Sbjct: 645 SSFTSSIRSRISGAEAFRRGTLGADSFAGGRSSARADAENAAFAEEVAKVMEQDGQISAG 704
Query: 1752 LREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYYSHLWALS 1573
+I K +Y + + I+G+ A L +EGF + D H A++
Sbjct: 705 FLDIFKNAHGNYTVMLLGFVTGLIRGLELTAFALLFGWVFEGFQYLTVDNGKMMHRMAMA 764
Query: 1572 FMFLAVFRPLTLYCQYY---YFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLS 1402
+ Q+ +F VSE L+ R R+ SF ++L +F+D+P H+ +L
Sbjct: 765 VIAYGCSGFGCFVSQFLSSVFFAIVSENLALRFRVMSFRNLLYQDASFFDNPAHAPGKLI 824
Query: 1401 NRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKM----TLEVLMFFPXXXXX 1234
RL TD+ N K VD R+ V+ + AI I A +YCW + T +++
Sbjct: 825 TRLATDAPNCKTVVDSRMLQVLYALSAIIANIAIAFIYCWYLAILGTALIILLAVTMCGL 884
Query: 1233 XXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSY 1054
IQ+D + R AIE +ENV+T++ L D + + +S
Sbjct: 885 AYKISLLNMKQIQDD-----EAGRIAIEIIENVKTIQLLTRCDHFFERYQKSSKSQKRSE 939
Query: 1053 FKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSA 874
K+ +I+ ++ S ++ F G L + + D + + + +TA ++
Sbjct: 940 LKKGLIEAVNYTITQSFMYYMMCFCFALGIRLIYQGNKSSQDVFQGNIAMLLTAMGVMNS 999
Query: 873 AAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMI 694
A Y P++ KA A+GL+F++ Y +G +G I+ E+V+F Y QRP + I
Sbjct: 1000 AQYFPEFVKAKTASGLLFNII-YRKPRTGDLMEGTCPEVRGNILFEDVKFSYPQRPHQPI 1058
Query: 693 LNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSN 514
+ G+ G+T+ALVGPSG GKST I +LERFY G ++ID +++ ++L HLR+
Sbjct: 1059 MKGLQWTALRGQTVALVGPSGSGKSTCIGMLERFYDVTGGVLRIDGQDIRGLSLFHLRTQ 1118
Query: 513 LALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERG 334
+ALV QEP LF +I+EN+ GL +V ++ AL+ ANA F+ P G++T VGE+G
Sbjct: 1119 MALVGQEPRLFAGTIKENICLGL-ENVSMEKINHALELANANRFLSNLPAGIETDVGEKG 1177
Query: 333 AQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHR 154
++LSGGQKQRIAIARA++R+PK+LLLDEATSALDS+SEK VQ ALD A E + + +AHR
Sbjct: 1178 SKLSGGQKQRIAIARALVRDPKILLLDEATSALDSESEKAVQEALDRAREGRTCITIAHR 1237
Query: 153 LSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQV 19
LS++ N+D I ++NG+V E G H++L+ K+ Y+ L+QKQ + +
Sbjct: 1238 LSSIQNSDVIVYIENGRVQEAGNHKQLMAKKGKYYELIQKQDLGI 1282
Score = 290 bits (742), Expect = 2e-76
Identities = 185/521 (35%), Positives = 278/521 (52%), Gaps = 39/521 (7%)
Frame = -1
Query: 3384 MNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVS--T 3211
M V + G F+ L V +N R R LL +DA +FD+ +
Sbjct: 761 MAMAVIAYGCSGFGCFVSQFLSSVFFAIVSENLALRFRVMSFRNLLYQDASFFDNPAHAP 820
Query: 3210 GHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYG--IFFSLGIA 3037
G L T L + + V + ++ ++ ++ A+AF W LA G + L +
Sbjct: 821 GKLITRLATDAPNCKTVVDSRMLQVLYALSAIIANIAIAFIYCWYLAILGTALIILLAVT 880
Query: 3036 FSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEK 2857
G ++ Q+ AG IA + + KT+ L ERY + K+ ++
Sbjct: 881 MCGLAYKISLLNMKQIQDDE---AGRIAIEIIENVKTIQLLTRCDHFFERYQKSSKSQKR 937
Query: 2856 YGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYSGT-------------LETAVVVR 2716
+++ L+ +++ +T F + +G +IY G L TA+ V
Sbjct: 938 SELKKGLIEAVNYTITQSFMYYMMCFCFALGIRLIYQGNKSSQDVFQGNIAMLLTAMGVM 997
Query: 2715 DD------------------NVIEKDETDYDVE----VEVNGNISFKNVKFSYPTRPDAQ 2602
+ N+I + D+ EV GNI F++VKFSYP RP
Sbjct: 998 NSAQYFPEFVKAKTASGLLFNIIYRKPRTGDLMEGTCPEVRGNILFEDVKFSYPQRPHQP 1057
Query: 2601 VLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRR 2422
++KG+ + G+ +ALVG SGSGKST + +L +Y++ G + IDG D+ +++ LR
Sbjct: 1058 IMKGLQWTALRGQTVALVGPSGSGKSTCIGMLERFYDVTGGVLRIDGQDIRGLSLFHLRT 1117
Query: 2421 VIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERG 2242
+ +V QEP LF TI+ENI G NVS+ +I AL ANA F+ + P GI+T VGE+G
Sbjct: 1118 QMALVGQEPRLFAGTIKENICLGLENVSMEKINHALELANANRFLSNLPAGIETDVGEKG 1177
Query: 2241 TQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHR 2062
++LSGGQKQRIAIAR LVR+PKILLLDEATSALD+ESE+ VQ+AL+ A +GRT I +AHR
Sbjct: 1178 SKLSGGQKQRIAIARALVRDPKILLLDEATSALDSESEKAVQEALDRAREGRTCITIAHR 1237
Query: 2061 LSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQ 1939
LS+I+N+ I+ ++ G + E GNH +L+AK+G Y +L+Q Q
Sbjct: 1238 LSSIQNSDVIVYIENGRVQEAGNHKQLMAKKGKYYELIQKQ 1278
>gi|15234322|ref|NP_192091.1| multidrug resistance P-glycoprotein,
putative [Arabidopsis thaliana]
gi|25297452|pir||D85023 P-glycoprotein-like protein pgp3 [imported] -
Arabidopsis thaliana
gi|4558551|gb|AAD22644.1| P-glycoprotein-like protein [Arabidopsis
thaliana]
gi|7268566|emb|CAB80675.1| P-glycoprotein-like protein pgp3
[Arabidopsis thaliana]
Length = 1229
Score = 662 bits (1709), Expect = 0.0
Identities = 417/1237 (33%), Positives = 642/1237 (51%), Gaps = 53/1237 (4%)
Frame = -1
Query: 3588 VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEK 3409
+F S + L ++G + ++ G P M+ FG++ ID +
Sbjct: 13 LFSFSDSTDVLLMIVGSIGAIGNGVGFPLMTLLFGDL---------------IDSIGQNQ 57
Query: 3408 AYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQY 3229
+ ++ +++V F G A LQ A G+ R+R Y+ +L++D +
Sbjct: 58 SNKDIVEIVSKVCLKFVYLGLGTLGAAFLQVACWMITGERQAARIRSLYLKTILRQDIGF 117
Query: 3228 FD-SVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFF 3052
FD STG + ++ + E EK+ I + F G LAF W L +
Sbjct: 118 FDVETSTGEVVGRMSGDTVLILEAMGEKVGKFIQLIATFVGGFVLAFVKGWLLTLVMLVS 177
Query: 3051 SLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEEL 2872
+A +G V + + ++ YA A ++ QTLG+ +TV S G+K ++ Y E +
Sbjct: 178 IPLLAIAGAAMPIIVTRASSREQAAYAKASTVVEQTLGSIRTVASFTGEKQAMKSYREFI 237
Query: 2871 KAGEKYGIRRALMYSISRGVTYF--FCNS---------------------LNTVVLYVGA 2761
+ +++ + GV +F FC+ +N +V V +
Sbjct: 238 NLAYRASVKQGFSMGLGLGVVFFVFFCSYALAIWFGGEMILKKGYTGGEVVNVMVTVVAS 297
Query: 2760 TMIYSGTLET--------AVVVRDDNVIEK----DETDYDVEV--EVNGNISFKNVKFSY 2623
+M T A + IE+ D D + +V ++ G I ++V FSY
Sbjct: 298 SMSLGQTTPCLTAFAAGKAAAYKMFETIERKPSIDAFDLNGKVLEDIRGEIELRDVCFSY 357
Query: 2622 PTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDM 2443
P RP +V G S + +G ALVG SGSGKS+V+ L+ +Y+ SG++ IDG++L +
Sbjct: 358 PARPMEEVFGGFSLLIPSGATAALVGESGSGKSSVISLIERFYDPSSGSVLIDGVNLKEF 417
Query: 2442 NIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIK 2263
+K +R IG+VSQEPVLF+++I ENI +G N ++ EI A + ANA +F+ P+G++
Sbjct: 418 QLKWIRGKIGLVSQEPVLFSSSIMENIGYGKENATVEEIQAAAKLANAANFIDKLPRGLE 477
Query: 2262 TIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRT 2083
T+VGE GTQLSGGQKQRIAIAR ++++P+ILLLDEATSALD ESE+VVQ+AL+ RT
Sbjct: 478 TLVGEHGTQLSGGQKQRIAIARAILKDPRILLLDEATSALDAESERVVQEALDRVMMSRT 537
Query: 2082 TIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIA-KRGVYNDLVQAQLLESHDDHEEL 1906
T++VAHRLST+RNA I V+ +G+IVE G+H EL+ G Y L++ Q ++ E
Sbjct: 538 TVIVAHRLSTVRNADMIAVIHRGKIVEEGSHSELLKDHEGAYAQLIRLQKIKKEPKRLE- 596
Query: 1905 PPLAARQLSQELSPLHSYAIQRSTSND--AGVHDDDMERIL--------DELSKEGAKKS 1756
+ L +I R +S + VHDDD +L E+S+E ++
Sbjct: 597 ----------SSNELRDRSINRGSSRNIRTRVHDDDSVSVLGLLGRQENTEISREQSRNV 646
Query: 1755 NLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYYSHLWAL 1576
++ I +P+ L + A+ G +PI L + E F DM S W++
Sbjct: 647 SITRIAALNKPETTILILGTLLGAVNGTIFPIFGILFAKVIEAFFKPPHDMKRDSRFWSM 706
Query: 1575 SFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNR 1396
F+ L V + Y F +L R+R+ F ++ + ++DDP +S+ + +R
Sbjct: 707 IFVLLGVASLIVYPMHTYLFAVAGGRLIQRIRVMCFEKVVHMEVGWFDDPENSSGTIGSR 766
Query: 1395 LNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXX 1216
L+ D++ +K V D L + A + A WK+ + +L+ P
Sbjct: 767 LSADAALIKTLVGDSLSLSVKNAAAAVSGLIIAFTASWKLAVIILVMIPLIGINGYLQIK 826
Query: 1215 XXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAII 1036
+ +E +++ A +A+ ++RTV + E+K+M + + + KS K+ +I
Sbjct: 827 FIKGFTADAKAKYEEASQVANDAVGSIRTVASFCAEEKVMEMYKKRCEDTIKSGIKQGLI 886
Query: 1035 QGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPD 856
G G+S VY+ F G L D + V + L+MTA A+++ PD
Sbjct: 887 SGVGFGISFFVLYSVYASCFYVGARLVKAGRTNFNDVFQVFLALTMTAIGISQASSFAPD 946
Query: 855 YKKAVHAAGLIFHLFTYPATMPFSSSDG--KKNIEKGEIIGENVQFHYDQRPDRMILNGV 682
KA AA IF + + + G +N+ KG+I ++ F Y RPD I +
Sbjct: 947 SSKAKGAAASIFGIIDGKSMIDSRDESGLVLENV-KGDIELCHISFTYQTRPDVQIFRDL 1005
Query: 681 NLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALV 502
+ G+T+ALVG SG GKST+ISLL+RFY G + +D ++ + L +R + LV
Sbjct: 1006 CFAIRAGQTVALVGESGSGKSTVISLLQRFYDPDSGHITLDRVELKKLQLKWVRQQMGLV 1065
Query: 501 SQEPTLFNCSIRENLLYGL-TRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQL 325
QEP LFN +IR N+ YG + E+ A + ANA F+ QG DT+VGERG QL
Sbjct: 1066 GQEPVLFNDTIRSNIAYGKGGDEASEAEIIAAAELANAHGFISSIQQGYDTVVGERGIQL 1125
Query: 324 SGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLST 145
SGGQKQR+AIARAI++ PK+LLLDEATSALD++SE+VVQ+ALD +TVVVAHRLST
Sbjct: 1126 SGGQKQRVAIARAIVKEPKILLLDEATSALDAESERVVQDALDRVMVNRTTVVVAHRLST 1185
Query: 144 VVNADSIAVLKNGKVAEQGTHEELLR-KRSIYWRLVQ 37
+ NAD IAV+KNG + E+GTHE L+ + +Y LVQ
Sbjct: 1186 IKNADVIAVVKNGVIVEKGTHETLINIEGGVYASLVQ 1222
>gi|13641444|gb|AAK31736.1| p-glycoprotein [Mucor racemosus]
Length = 1292
Score = 662 bits (1708), Expect = 0.0
Identities = 426/1282 (33%), Positives = 671/1282 (52%), Gaps = 78/1282 (6%)
Frame = -1
Query: 3636 QSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTI 3457
Q + K + S R+ F+ ++ + L + S TG QP FG V + L
Sbjct: 25 QDTKSKKKETVSIFRL-FQFATTRDLLLICIAGFCSCTTGAIQPISILFFGNVLKKL--- 80
Query: 3456 TNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYR 3277
++ DL +A M + + +L G A + + + G+N R
Sbjct: 81 ----GEAIVEGNDLMEAT------MPIIKLYVYL-GTGVMTAAYISNCLWVLTGENQARR 129
Query: 3276 VRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTAL 3097
+R+ Y+ +L+++ +FD G L+T L+ +++ ++ +EK + F G ++
Sbjct: 130 IRQLYVHSILRQEMSWFDKSEEGSLTTRLSADVQLIQDGISEKFGQFLMCFAQFIAGCSV 189
Query: 3096 AFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCS 2917
AF WRL+ I + IA +G + V K T + YA+AGSI+ Q +TV S
Sbjct: 190 AFSKGWRLSIVMIAVTPAIACTGGVMGILVTKYTVETQDAYADAGSISEQVFAGIRTVYS 249
Query: 2916 LNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYSGTL 2737
+ Q +RY E+L + GI+R ++ G+ F ++ + + G+ +++ +
Sbjct: 250 FSLQNRFAKRYEEKLDKAMRAGIKRGIILGTGLGIFMFCLFAMYGLSFWYGSRLVHDHIM 309
Query: 2736 ETAVV-------------------------------------VRDDNVIEKDETDYDVEV 2668
+ + V ++ I+ D +
Sbjct: 310 DGSTVLVVFLSMMMGEFSLLQLPTNLAAVSSASAAAYKIFETIKRVPDIDTSSPDGVIPS 369
Query: 2667 EVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNI 2488
+V G + FK+VKF YPTRPD +LK +S ++ G +A VG SGSGKST VQLL +Y+
Sbjct: 370 QVLGELEFKHVKFRYPTRPDTIILKDLSLKIKPGMTVAFVGPSGSGKSTSVQLLQRFYDP 429
Query: 2487 DSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFG--NPNVSLPEIYGAL 2314
SG++ +DG +L ++N+K LR+ IGVVSQEPVLFNT+I +N+ G N N+S+ EI A
Sbjct: 430 MSGSVSLDGKNLKELNVKWLRQQIGVVSQEPVLFNTSIRQNLMMGSENRNISMEEITAAC 489
Query: 2313 RKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNE 2134
+KAN + F+ PKG T+VGE G LSGGQKQRIAIAR +++NP ILLLDEATSALD +
Sbjct: 490 KKANCHSFIKQLPKGYSTLVGEHGGMLSGGQKQRIAIARAILKNPAILLLDEATSALDTQ 549
Query: 2133 SEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYND 1954
SE++VQKAL+ A+ RTTIVVAHRLST+RNA I+VMQ G+++E G HD+LIAK GVY++
Sbjct: 550 SERLVQKALDEAAANRTTIVVAHRLSTVRNADLIVVMQHGDLIEQGTHDDLIAKGGVYSE 609
Query: 1953 LVQAQLLE----------SHDDHEELPPLAARQLSQELSPLHSYAIQRSTSNDAGVHDDD 1804
LV+ Q ++ + + E+ + R + E++ + R+ SN+A +
Sbjct: 610 LVKKQQIQTSSNNTHNRKTKQEEEQEDEILLRNEAMEVNRKSCIELNRA-SNNASIISVP 668
Query: 1803 MER-----ILDELSKEGAKKSNLRE-----------IVKQCRPDYCFLFIAVFGSAIQGV 1672
R +LD +E A + +E + Q RP + + + G+ I G
Sbjct: 669 AARKSRFSVLDGFGREAASRKEAQEKHAKMKAPVWKVFMQMRPQWGWCMLGSIGACIAGT 728
Query: 1671 SYPILAQLIVRTYEGFAMIGED------MLYYSHLWALSFMFLAVFRPLTLYCQYYYFGK 1510
+P+ A + M+ E+ + ++++ F+ L +F L Q F
Sbjct: 729 VFPLYALFFAKV---ITMLNENDDKDYGPMEGPNMYSFLFVILGMFAFLGFALQTVSFEI 785
Query: 1509 VSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMT 1330
+ + LR F + ++D ++ L+++L D+ NV + V+
Sbjct: 786 AGAKYTKTLRSMLFVSFMKQEIGYFDRDENNVGSLTSKLAVDAKNVNEMITRAWPDVVQI 845
Query: 1329 VVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIE 1150
+I +T A ++ WK+TL ++ P A E S A E
Sbjct: 846 AFTSAIGMTIAFMHSWKLTLIIMCMTPLIVGAAGWNSKVQEGFEGSTKEANEQSAEVASE 905
Query: 1149 ALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKF 970
A++ +RTV ALN + ++ H+ ++A L L+ +V+F
Sbjct: 906 AIKEIRTVTALNKQSYFEERYYNATERPHRLAQRKAYTSSIGFALLQGTSLYTNAVAFYA 965
Query: 969 GTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMP 790
G+ L + + D + +M++ + A+ G ++ ++ + KA AA F + +
Sbjct: 966 GSKLITQGNLDLSDMVITMMSIMIMADGVGRSSIFVSTFAKAKIAAITTFEVLNRQPAID 1025
Query: 789 FSSSDGKKNIE--KGEIIGENVQFHYDQRPDRMILNG-VNLKVDPGKTLALVGPSGCGKS 619
+ E G+I ++ F Y RPD I +G NLK G+T+ALVGPSG GKS
Sbjct: 1026 SELEGIEPEGEDIDGDIDFSSIAFRYPARPDIPIFDGEFNLKGKQGQTIALVGPSGSGKS 1085
Query: 618 TIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGL-- 445
T I +L+R+Y + G V++D+ NV+ L +LRS++ALVSQEPTLF+ +I EN+ +G+
Sbjct: 1086 TTIGMLQRWYDPLSGTVRVDNHNVKSYTLGNLRSHMALVSQEPTLFDMTIGENIRFGVDD 1145
Query: 444 TRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKV 265
++ V Q E+E ++AN NF+ P+G D VG++G+QLSGGQKQRIAIARA++R PK+
Sbjct: 1146 SKEVTQEEVEAVCKSANIHNFIVSLPKGYDQRVGDKGSQLSGGQKQRIAIARALIRKPKI 1205
Query: 264 LLLDEATSALDSDSEKVVQNALDTASER--LSTVVVAHRLSTVVNADSIAVLKNGKVAEQ 91
LLLDEATSALDS+SEK+VQ ALD + +T+ +AHRLST+ NAD I V+K+GKV EQ
Sbjct: 1206 LLLDEATSALDSESEKLVQKALDNIIQEGGRTTITIAHRLSTITNADLICVIKDGKVIEQ 1265
Query: 90 GTHEELLRKRSIYWRLVQKQGI 25
G H +LL+ +Y LVQ+Q +
Sbjct: 1266 GNHWQLLKLDGVYKSLVQQQSL 1287
Score = 310 bits (795), Expect = 1e-82
Identities = 203/617 (32%), Positives = 317/617 (50%), Gaps = 11/617 (1%)
Frame = -1
Query: 1830 NDAGVHDD--DMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPIL 1657
+D + DD D D SK+ S R D + IA F S G PI
Sbjct: 10 DDTLLRDDTADQPATQDTKSKKKETVSIFRLFQFATTRDLLLICIAGFCSCTTGAIQPIS 69
Query: 1656 AQLIVRTYE--GFAMI-GEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTR 1486
+ G A++ G D++ + +++L Y + E + R
Sbjct: 70 ILFFGNVLKKLGEAIVEGNDLMEATMPIIKLYVYLGTGVMTAAYISNCLWVLTGENQARR 129
Query: 1485 LRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAI 1306
+R +L +++D + L+ RL+ D ++ + ++ G +M
Sbjct: 130 IRQLYVHSILRQEMSWFDKSEEGS--LTTRLSADVQLIQDGISEKFGQFLMCFAQFIAGC 187
Query: 1305 TTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTV 1126
+ A W++++ ++ P E A+ ++ + + +RTV
Sbjct: 188 SVAFSKGWRLSIVMIAVTPAIACTGGVMGILVTKYTVETQDAYADAGSISEQVFAGIRTV 247
Query: 1125 RALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRK 946
+ +L+++ E L K ++ KR II G G+ + C +Y +SF +G+ L +
Sbjct: 248 YSFSLQNRFAKRYEEKLDKAMRAGIKRGIILGTGLGIFMFCLFAMYGLSFWYGSRL-VHD 306
Query: 945 EVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLI-FHLFTYPATMPFSSSDGK 769
+ T LV+ M M + LP AV +A + +F +P +
Sbjct: 307 HIMDGSTVLVVFLSMM---MGEFSLLQLPTNLAAVSSASAAAYKIFETIKRVPDIDTSSP 363
Query: 768 KNIEKGEIIGE----NVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLL 601
+ +++GE +V+F Y RPD +IL ++LK+ PG T+A VGPSG GKST + LL
Sbjct: 364 DGVIPSQVLGELEFKHVKFRYPTRPDTIILKDLSLKIKPGMTVAFVGPSGSGKSTSVQLL 423
Query: 600 ERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGL-TRSVPQL 424
+RFY + G V +D +N++++N+ LR + +VSQEP LFN SIR+NL+ G R++
Sbjct: 424 QRFYDPMSGSVSLDGKNLKELNVKWLRQQIGVVSQEPVLFNTSIRQNLMMGSENRNISME 483
Query: 423 ELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEAT 244
E+ A + AN +F+ Q P+G TLVGE G LSGGQKQRIAIARAIL+NP +LLLDEAT
Sbjct: 484 EITAACKKANCHSFIKQLPKGYSTLVGEHGGMLSGGQKQRIAIARAILKNPAILLLDEAT 543
Query: 243 SALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRK 64
SALD+ SE++VQ ALD A+ +T+VVAHRLSTV NAD I V+++G + EQGTH++L+ K
Sbjct: 544 SALDTQSERLVQKALDEAAANRTTIVVAHRLSTVRNADLIVVMQHGDLIEQGTHDDLIAK 603
Query: 63 RSIYWRLVQKQGIQVET 13
+Y LV+KQ IQ +
Sbjct: 604 GGVYSELVKKQQIQTSS 620
Score = 273 bits (699), Expect = 2e-71
Identities = 191/587 (32%), Positives = 288/587 (48%), Gaps = 46/587 (7%)
Frame = -1
Query: 3549 LLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQVV 3370
+LG + + + G P + F +V +T+ N ++K P + G N
Sbjct: 717 MLGSIGACIAGTVFPLYALFFAKV----ITMLNENDDKDYGPME----------GPNMYS 762
Query: 3369 FHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQYFD--SVSTGHLST 3196
F F + G F+ +LQ + G T +R +K++ YFD + G L++
Sbjct: 763 FLFVILGMFAFLGFALQTVSFEIAGAKYTKTLRSMLFVSFMKQEIGYFDRDENNVGSLTS 822
Query: 3195 VLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINS 3016
L + + E+ ++ +G +AF W+L + + I + NS
Sbjct: 823 KLAVDAKNVNEMITRAWPDVVQIAFTSAIGMTIAFMHSWKLTLIIMCMTPLIVGAAGWNS 882
Query: 3015 AGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRAL 2836
G + +A + + +TV +LN Q ERY + + R+A
Sbjct: 883 KVQEGFEGSTKEANEQSAEVASEAIKEIRTVTALNKQSYFEERYYNATERPHRLAQRKAY 942
Query: 2835 MYSISRGVTYFFCNSLNTVVLYVGATMIYSGTLETA--------VVVRDDNV-------- 2704
SI + N V Y G+ +I G L+ + +++ D V
Sbjct: 943 TSSIGFALLQGTSLYTNAVAFYAGSKLITQGNLDLSDMVITMMSIMIMADGVGRSSIFVS 1002
Query: 2703 --------------IEKDETDYDVEVE--------VNGNISFKNVKFSYPTRPDAQVLKG 2590
+ + D E+E ++G+I F ++ F YP RPD + G
Sbjct: 1003 TFAKAKIAAITTFEVLNRQPAIDSELEGIEPEGEDIDGDIDFSSIAFRYPARPDIPIFDG 1062
Query: 2589 -ISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIG 2413
+ + G+ IALVG SGSGKST + +L +Y+ SG + +D ++ + LR +
Sbjct: 1063 EFNLKGKQGQTIALVGPSGSGKSTTIGMLQRWYDPLSGTVRVDNHNVKSYTLGNLRSHMA 1122
Query: 2412 VVSQEPVLFNTTIEENIRFG---NPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERG 2242
+VSQEP LF+ TI ENIRFG + V+ E+ + AN ++F+ S PKG VG++G
Sbjct: 1123 LVSQEPTLFDMTIGENIRFGVDDSKEVTQEEVEAVCKSANIHNFIVSLPKGYDQRVGDKG 1182
Query: 2241 TQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQ--GRTTIVVA 2068
+QLSGGQKQRIAIAR L+R PKILLLDEATSALD+ESE++VQKAL+N Q GRTTI +A
Sbjct: 1183 SQLSGGQKQRIAIARALIRKPKILLLDEATSALDSESEKLVQKALDNIIQEGGRTTITIA 1242
Query: 2067 HRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLES 1927
HRLSTI NA I V++ G+++E GNH +L+ GVY LVQ Q L S
Sbjct: 1243 HRLSTITNADLICVIKDGKVIEQGNHWQLLKLDGVYKSLVQQQSLSS 1289
>gi|25455873|pir||T52319 P-glycoprotein-like protein pgp3 [imported] -
Arabidopsis thaliana
gi|2739309|emb|CAA75922.1| P-glycoprotein-like protein [Arabidopsis
thaliana]
Length = 1229
Score = 661 bits (1706), Expect = 0.0
Identities = 416/1237 (33%), Positives = 642/1237 (51%), Gaps = 53/1237 (4%)
Frame = -1
Query: 3588 VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEK 3409
+F S + L ++G + ++ G P M+ FG++ ID +
Sbjct: 13 LFSFSDSTDVLLMIVGSIGAIGNGVGFPLMTLLFGDL---------------IDSIGQNQ 57
Query: 3408 AYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQY 3229
+ ++ +++V F G A L+ A G+ R+R Y+ +L++D +
Sbjct: 58 SNKDIVEIVSKVCLKFVYLGLGTLGAAFLEVACWMITGERQAARIRSLYLKTILRQDIGF 117
Query: 3228 FD-SVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFF 3052
FD STG + ++ + E EK+ I + F G LAF W L +
Sbjct: 118 FDVETSTGEVVGRMSGDTVLILEAMGEKVGKFIQLIATFVGGFVLAFVKGWLLTLVMLVS 177
Query: 3051 SLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEEL 2872
+A +G V + + ++ YA A ++ QTLG+ +TV S G+K ++ Y E +
Sbjct: 178 IPLLAIAGAAMPIIVTRASSREQAAYAKASTVVEQTLGSIRTVASFTGEKQAMKSYREFI 237
Query: 2871 KAGEKYGIRRALMYSISRGVTYF--FCNS---------------------LNTVVLYVGA 2761
+ +++ + GV +F FC+ +N +V V +
Sbjct: 238 NLAYRASVKQGFSMGLGLGVVFFVFFCSYALAIWFGGEMILKKGYTGGEVVNVMVTVVAS 297
Query: 2760 TMIYSGTLET--------AVVVRDDNVIEK----DETDYDVEV--EVNGNISFKNVKFSY 2623
+M T A + IE+ D D + +V ++ G I ++V FSY
Sbjct: 298 SMSLGQTTPCLTAFAAGKAAAYKMFETIERKPSIDAFDLNGKVLEDIRGEIELRDVCFSY 357
Query: 2622 PTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDM 2443
P RP +V G S + +G ALVG SGSGKS+V+ L+ +Y+ SG++ IDG++L +
Sbjct: 358 PARPMEEVFGGFSLLIPSGATAALVGESGSGKSSVISLIERFYDPSSGSVLIDGVNLKEF 417
Query: 2442 NIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIK 2263
+K +R IG+VSQEPVLF+++I ENI +G N ++ EI A + ANA +F+ P+G++
Sbjct: 418 QLKWIRGKIGLVSQEPVLFSSSIMENIGYGKENATVEEIQAAAKLANAANFIDKLPRGLE 477
Query: 2262 TIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRT 2083
T+VGE GTQLSGGQKQRIAIAR ++++P+ILLLDEATSALD ESE+VVQ+AL+ RT
Sbjct: 478 TLVGEHGTQLSGGQKQRIAIARAILKDPRILLLDEATSALDAESERVVQEALDRVMMSRT 537
Query: 2082 TIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIA-KRGVYNDLVQAQLLESHDDHEEL 1906
T++VAHRLST+RNA I V+ +G+IVE G+H EL+ G Y L++ Q ++ E
Sbjct: 538 TVIVAHRLSTVRNADMIAVIHRGKIVEEGSHSELLKDHEGAYAQLIRLQKIKKEPKRLE- 596
Query: 1905 PPLAARQLSQELSPLHSYAIQRSTSND--AGVHDDDMERIL--------DELSKEGAKKS 1756
+ L +I R +S + VHDDD +L E+S+E ++
Sbjct: 597 ----------SSNELRDRSINRGSSRNIRTRVHDDDSVSVLGLLGRQENTEISREQSRNV 646
Query: 1755 NLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYYSHLWAL 1576
++ I +P+ L + A+ G +PI L + E F DM S W++
Sbjct: 647 SITRIAALNKPETTILILGTLLGAVNGTIFPIFGILFAKVIEAFFKPPHDMKRDSRFWSM 706
Query: 1575 SFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNR 1396
F+ L V + Y F +L R+R+ F ++ + ++DDP +S+ + +R
Sbjct: 707 IFVLLGVASLIVYPMHTYLFAVAGGRLIQRIRVMCFEKVVHMEVGWFDDPENSSGTIGSR 766
Query: 1395 LNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXX 1216
L+ D++ +K V D L + A + A WK+ + +L+ P
Sbjct: 767 LSADAALIKTLVGDSLSLSVKNAAAAVSGLIIAFTASWKLAVIILVMIPLIGINGYLQIK 826
Query: 1215 XXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAII 1036
+ +E +++ A +A+ ++RTV + E+K+M + + + KS K+ +I
Sbjct: 827 FIKGFTADAKAKYEEASQVANDAVGSIRTVASFCAEEKVMEMYKKRCEDTIKSGIKQGLI 886
Query: 1035 QGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPD 856
G G+S VY+ F G L D + V + L+MTA A+++ PD
Sbjct: 887 SGVGFGISFFVLYSVYASCFYVGARLVKAGRTNFNDVFQVFLALTMTAIGISQASSFAPD 946
Query: 855 YKKAVHAAGLIFHLFTYPATMPFSSSDG--KKNIEKGEIIGENVQFHYDQRPDRMILNGV 682
KA AA IF + + + G +N+ KG+I ++ F Y RPD I +
Sbjct: 947 SSKAKGAAASIFGIIDGKSMIDSRDESGLVLENV-KGDIELCHISFTYQTRPDVQIFRDL 1005
Query: 681 NLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALV 502
+ G+T+ALVG SG GKST+ISLL+RFY G + +D ++ + L +R + LV
Sbjct: 1006 CFAIRAGQTVALVGESGSGKSTVISLLQRFYDPDSGHITLDRVELKKLQLKWVRQQMGLV 1065
Query: 501 SQEPTLFNCSIRENLLYGL-TRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQL 325
QEP LFN +IR N+ YG + E+ A + ANA F+ QG DT+VGERG QL
Sbjct: 1066 GQEPVLFNDTIRSNIAYGKGGDEASEAEIIAAAELANAHGFISSIQQGYDTVVGERGIQL 1125
Query: 324 SGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLST 145
SGGQKQR+AIARAI++ PK+LLLDEATSALD++SE+VVQ+ALD +TVVVAHRLST
Sbjct: 1126 SGGQKQRVAIARAIVKEPKILLLDEATSALDAESERVVQDALDRVMVNRTTVVVAHRLST 1185
Query: 144 VVNADSIAVLKNGKVAEQGTHEELLR-KRSIYWRLVQ 37
+ NAD IAV+KNG + E+GTHE L+ + +Y LVQ
Sbjct: 1186 IKNADVIAVVKNGVIVEKGTHETLINIEGGVYASLVQ 1222
>gi|11038656|ref|NP_066302.1| ATP-binding cassette, sub-family B,
member 11; bile salt export pump; sister of
P-glycoprotein [Mus musculus]
gi|12643304|sp|Q9QY30|AB11_MOUSE Bile salt export pump (ATP-binding
cassette, sub-family B, member 11) (Sister of
P-glycoprotein)
gi|6502606|gb|AAF14372.1| liver bile salt export pump;
sister-of-p-glycoprotein [Mus musculus domesticus]
Length = 1321
Score = 660 bits (1704), Expect = 0.0
Identities = 425/1271 (33%), Positives = 656/1271 (51%), Gaps = 88/1271 (6%)
Frame = -1
Query: 3588 VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTID-PADLE 3412
+F+ SS + +L +G + +L+ G QP M FG ++ + V +I +
Sbjct: 50 LFRFSSSKDNWLMFMGSVCALLHGMAQPGMIIVFGILTDIFVEYDIERQELSIPGKVCMN 109
Query: 3411 KAYEEYERGMNQVVFHFFLCGC-------------------AYFIFASLQHAIMKYVGDN 3289
NQ + + CG A I Q + G
Sbjct: 110 NTIVWINSSFNQNMTNGTSCGLVDINSEVIKFSGIYAGVGVAVLILGYFQIRLWVITGAR 169
Query: 3288 TTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTL 3109
++RK Y R+++ + +FD S G L++ +D++ + E +++AL + ++
Sbjct: 170 QIRKMRKFYFRRIMRMEIGWFDCTSVGELNSRFSDDINKIDEAIADQMALFLQRLSTALS 229
Query: 3108 GTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYK 2929
G L FY W+L + S I + V K T + YA AGSIA + L + +
Sbjct: 230 GLLLGFYRGWKLTLVILAVSPLIGIGAAVIGLSVAKFTELELKAYAKAGSIADEVLSSIR 289
Query: 2928 TVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTY---FFCNSLNTVVLYVGAT 2758
TV + G+ E+ERY + L +++GI + ++ G + FFC +L + G+
Sbjct: 290 TVAAFGGENKEVERYEKNLMFAQRWGIWKGMVMGFFTGYMWCLIFFCYAL---AFWYGSR 346
Query: 2757 MIYS------GTLET---AVVVRDDNV-----------------------IEKDET---- 2686
++ GTL V++ N+ I++
Sbjct: 347 LVLDEGEYTPGTLIQIFLCVIIAAMNIGNASSCLEIFSTGCSAASSIFQTIDRQPVMDCM 406
Query: 2685 ---DYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVV 2515
Y ++ + G I F NV F YP+RP+ ++L +S ++ GE A VG+SG+GKST +
Sbjct: 407 SGDGYKLD-RIKGEIEFHNVTFHYPSRPEVKILNNLSMVIKPGETTAFVGSSGAGKSTAL 465
Query: 2514 QLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSL 2335
QL+ +Y+ G + +DG D+ +NI+ LR IG+V QEPVLF+TTI ENIR G ++
Sbjct: 466 QLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAENIRLGREEATM 525
Query: 2334 PEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEA 2155
+I A + ANAY+F+ + P+ T+VGE G Q+SGGQKQR+AIAR L+R PKILLLD A
Sbjct: 526 EDIVQAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQKQRVAIARALIRKPKILLLDMA 585
Query: 2154 TSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIA 1975
TSALDNESE VQ AL G T I VAHRLST+R+A II + G VE G H+EL+
Sbjct: 586 TSALDNESEAKVQGALNKIQHGHTIISVAHRLSTVRSADVIIGFEHGTAVERGTHEELLE 645
Query: 1974 KRGVYNDLVQAQLLESH----------DDHEELPPLAARQLSQELSPLHSYAIQRSTSND 1825
++GVY LV Q E + D E P L + QRS S
Sbjct: 646 RKGVYFMLVTLQSQEDNTHKETGIKGKDTTEGDTPERTFSRGSYQDSLRASIRQRSKSQL 705
Query: 1824 AGVHDDDMERILDELSKEGAKKSN-----------LREIVKQCRPDYCFLFIAVFGSAIQ 1678
+ + + I D S +K N +R I+K ++ ++ + +AI
Sbjct: 706 SHLSHEPPLAIGDHKSSYEDRKDNDVLVEEVEPAPVRRILKYNISEWPYILVGALCAAIN 765
Query: 1677 GVSYPILAQLIVRTYEGFAMIG-EDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSE 1501
G PI + L + + F+++ E + L F+ L T + Q Y F K E
Sbjct: 766 GAVTPIYSLLFSQILKTFSLVDKEQQRSEIYSMCLFFVILGCVSLFTQFLQGYNFAKSGE 825
Query: 1500 QLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVA 1321
L+ RLR F ML ++DD ++ L+ RL TD+S V+ A ++G ++ +
Sbjct: 826 LLTKRLRKFGFKAMLRQDIGWFDDLKNNPGVLTTRLATDASQVQGATGSQVGMMVNSFTN 885
Query: 1320 ISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALE 1141
I +A+ A L+ WK++L + +FFP +D E + + EAL
Sbjct: 886 IFVAVLIAFLFNWKLSLVISVFFPFLALSGAVQTKMLTGFASQDKEILEKAGQITNEALS 945
Query: 1140 NVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTY 961
N+RTV + +E + + L+K +K+ ++A + G S S ++++G Y
Sbjct: 946 NIRTVAGIGVEGRFIKAFEVELEKSYKTAIRKANVYGLCYAFSQGISFLANSAAYRYGGY 1005
Query: 960 LALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSS 781
L + +++ + V+ +++M+A G +Y P Y KA +A F L + S
Sbjct: 1006 LIVYEDLNFSYVFRVVSSIAMSATAVGRTFSYTPSYAKAKISAARFFQLLDRKPPIDVYS 1065
Query: 780 SDGKK-NIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISL 604
G+K + +G+I + +F Y RPD +LNG+++ VDPG+TLA VG SGCGKST I L
Sbjct: 1066 GAGEKWDNFQGKIDFIDCKFTYPSRPDIQVLNGLSVSVDPGQTLAFVGSSGCGKSTSIQL 1125
Query: 603 LERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQL 424
LERFY G V ID + + +N+ LRSN+ +VSQEP LF+CSI +N+ YG + ++
Sbjct: 1126 LERFYDPDQGTVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFDCSIMDNIKYG--DNTKEI 1183
Query: 423 ELEKAL---QTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLD 253
+E+A+ + A +FV P+ +T VG +G+QLS G+KQRIAIARAI+R+PK+LLLD
Sbjct: 1184 SVERAIAAAKQAQLHDFVMSLPEKYETNVGIQGSQLSRGEKQRIAIARAIVRDPKILLLD 1243
Query: 252 EATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEEL 73
EATSALD++SEK VQ ALD A E + +V+AHRLST+ N+D IAV+ G V E+GTH++L
Sbjct: 1244 EATSALDTESEKTVQLALDKAREGRTCIVIAHRLSTIQNSDIIAVMSQGVVIEKGTHKKL 1303
Query: 72 LRKRSIYWRLV 40
+ ++ Y++LV
Sbjct: 1304 MDQKGAYYKLV 1314
Score = 281 bits (720), Expect = 6e-74
Identities = 167/494 (33%), Positives = 263/494 (52%), Gaps = 2/494 (0%)
Frame = -1
Query: 1488 RLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIA 1309
++R F ++ + ++D S L++R + D + + A+ D++ + +
Sbjct: 173 KMRKFYFRRIMRMEIGWFDCT--SVGELNSRFSDDINKIDEAIADQMALFLQRLSTALSG 230
Query: 1308 ITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRT 1129
+ WK+TL +L P + + A+ + A E L ++RT
Sbjct: 231 LLLGFYRGWKLTLVILAVSPLIGIGAAVIGLSVAKFTELELKAYAKAGSIADEVLSSIRT 290
Query: 1128 VRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALR 949
V A E+K + ++L + + ++ G G F Y+++F +G+ L L
Sbjct: 291 VAAFGGENKEVERYEKNLMFAQRWGIWKGMVMGFFTGYMWCLIFFCYALAFWYGSRLVLD 350
Query: 948 K-EVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDG 772
+ E P + + + + A G+A++ L + AA IF M S DG
Sbjct: 351 EGEYTPGTLIQIFLCVIIAAMNIGNASSCLEIFSTGCSAASSIFQTIDRQPVMDCMSGDG 410
Query: 771 KK-NIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLER 595
K + KGEI NV FHY RP+ ILN +++ + PG+T A VG SG GKST + L++R
Sbjct: 411 YKLDRIKGEIEFHNVTFHYPSRPEVKILNNLSMVIKPGETTAFVGSSGAGKSTALQLIQR 470
Query: 594 FYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELE 415
FY +G V +D ++ +N+ LR + +V QEP LF+ +I EN+ G + + ++
Sbjct: 471 FYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAENIRLGREEATME-DIV 529
Query: 414 KALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSAL 235
+A + ANA+NF+ PQ DTLVGE G Q+SGGQKQR+AIARA++R PK+LLLD ATSAL
Sbjct: 530 QAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQKQRVAIARALIRKPKILLLDMATSAL 589
Query: 234 DSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSI 55
D++SE VQ AL+ + + VAHRLSTV +AD I ++G E+GTHEELL ++ +
Sbjct: 590 DNESEAKVQGALNKIQHGHTIISVAHRLSTVRSADVIIGFEHGTAVERGTHEELLERKGV 649
Query: 54 YWRLVQKQGIQVET 13
Y+ LV Q + T
Sbjct: 650 YFMLVTLQSQEDNT 663
>gi|18496818|gb|AAL74250.1| ABC transporter AbcB3 [Dictyostelium
discoideum]
Length = 1432
Score = 658 bits (1697), Expect = 0.0
Identities = 431/1293 (33%), Positives = 668/1293 (51%), Gaps = 107/1293 (8%)
Frame = -1
Query: 3588 VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEK 3409
+F+ + +K L LG + +++ G P +S FG LV DP
Sbjct: 168 LFRFADNTDKVLMFLGTIAAVINGAAMPTVSLVFG-----LVVDAFKPTQFNDDPN---- 218
Query: 3408 AYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQY 3229
Y+ Y+ + + F+ + G F+ + L+ + G+ T R+R++Y+ L+++ +
Sbjct: 219 -YDIYDT-VRSISFYLLMLGGGVFVLSYLETTLWMIAGERQTSRIRREYLESTLRQEIGW 276
Query: 3228 FDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFS 3049
FD+ LS+ +N + F E EK+ I F + F G + F W+L S
Sbjct: 277 FDTNKANELSSRINSDTVLFEEAIGEKVGRFIHFFSTFVAGFVIGFTKGWQLTLVITSVS 336
Query: 3048 LGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELK 2869
+A GF + + + T Y+ AG +A + +G+ +TV + +G+K I++Y+ LK
Sbjct: 337 PLLAIGGFFTAKMMTQMTKLGQEAYSRAGGVAEENIGSIRTVATFSGEKLAIDKYSNNLK 396
Query: 2868 AGEKYGIRRALMYSISRGVTYFFC--------------------NSLNT----------- 2782
G +R+ + G F NS++
Sbjct: 397 DARTVGYKRSFFNGLGLGFVQFVILGTYALAFWYGSTLISNKVTNSVSDRPWTGGDVVSV 456
Query: 2781 -VVLYVGATMIYSGTLETAVVVRDDNVIEKDETDYDVEVEVN-------------GNISF 2644
+ +GAT I + A+ + K D + + N G I F
Sbjct: 457 FFAVIIGATSIGQASPCLALFAQGRGAAYKIFQVIDRQSKANPFSTRGIKPETLSGEIEF 516
Query: 2643 KNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFID 2464
K+V F YP+RPD + G + ++ G+ + LVG SG GKST++ LL +Y+ G I +D
Sbjct: 517 KDVGFHYPSRPDVPIFNGFNLKIKPGQTVGLVGDSGGGKSTIISLLERFYDPCQGEILLD 576
Query: 2463 GMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVC 2284
G D+ N++ LR+ IG+V+QEPVLF TTI ENIR+G + EI A + ANA+ F+
Sbjct: 577 GEDIRKFNVRGLRQKIGLVNQEPVLFATTISENIRYGKEGATQDEIEEAAKLANAHSFIS 636
Query: 2283 SFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALE 2104
P+G T+VGE+G Q+SGGQ+QRIAIAR +++NP ILLLDE+TSALD ES ++VQ+AL+
Sbjct: 637 QLPQGYNTLVGEKGVQMSGGQRQRIAIARAVIKNPNILLLDESTSALDAESTKLVQEALD 696
Query: 2103 NASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLESH 1924
+GRTTIV+AH LSTIRNA II ++KG VE G HDEL+AK+G+Y DLV+ Q SH
Sbjct: 697 VLMKGRTTIVIAHNLSTIRNADVIIYIKKGVAVERGTHDELMAKQGLYFDLVEKQ---SH 753
Query: 1923 DDHEELPPLAARQ-----LSQELSP-LHSYAIQRST--SNDAGVHDDDMERILDELSKEG 1768
L R S E++P L S+ + + + N++ + D E ++ K+
Sbjct: 754 QQMYNLLENGTRSRRSSTFSAEVNPLLDSFHVSKRSLRKNESESNKKDKEDSNNKKKKKS 813
Query: 1767 AKKS----NLREIVKQCRPD---YCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGE 1609
KK + +VK RP+ +CF F++ G+ G YP GFAM+
Sbjct: 814 NKKKVEEVPMSRVVKYNRPELGLWCFGFLSAVGT---GAVYP-----------GFAMVFT 859
Query: 1608 DMLY------------YSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFS 1465
+ML +++ AL F+ LAV ++ + Q + F + E+L+ RLR F+
Sbjct: 860 EMLTIFQNPDPNYLTDHANFVALMFVALAVGAGISNFFQGFLFSVIGEKLTYRLRRDCFA 919
Query: 1464 HMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYC 1285
++ ++D P +S +L++ L TD++ V+ RLG V+ ++ + + A
Sbjct: 920 AIMRQDVGWFDLPENSTGKLTSHLATDAALVQGMTSQRLGIVLQNILTMVGGLVIAFYSG 979
Query: 1284 WKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLED 1105
W++TL ++ FP +D + + A EA+ +RTV + E
Sbjct: 980 WQLTLVIIACFPLVVITSKVQMQILAGFSSKDGCG--PAGQVASEAISGIRTVASFTTEK 1037
Query: 1104 KIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYL-------ALRK 946
+++ L + + K+A I G A G + VY +SF +G L A K
Sbjct: 1038 QVVELYKKQQKGPSSEGIKKAHISGFAFGFTQLILFCVYCLSFWYGGKLVGSGVFGATDK 1097
Query: 945 EVAPMDT-----YL----------------------VLMTLSMTANMAGSAAAYLPDYKK 847
E++ T YL V + M+A G A+++ PD K
Sbjct: 1098 EISDNCTPQTIPYLWKDYDTCERAQNTIYGFNSMTRVFFAIVMSAIGVGQASSFAPDLAK 1157
Query: 846 AVHAAGLIFHLFTYPATMPFSSSDGKK-NIEKGEIIGENVQFHYDQRPDRMILNGVNLKV 670
A AA +F L P+ + ++ DG + +I G+I +N+ F Y RPD + G L +
Sbjct: 1158 AKAAAVSVFKLLDTPSKIDPTTEDGDRIDIVGGDIEFKNLHFSYPTRPDNSVFRGFTLTL 1217
Query: 669 DPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEP 490
G T ALVG SG GKST +SLL+RFY+ V GE+ ID N++++N+ HLR LV QEP
Sbjct: 1218 QSGTTTALVGDSGGGKSTCLSLLQRFYNPVVGEIFIDGHNIKNLNVRHLRHLFGLVGQEP 1277
Query: 489 TLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQK 310
TLF+ +I +N+ YG Q E+E+A + +N+ +F+ P G +T +GE+ QLSGGQK
Sbjct: 1278 TLFSGTIADNIRYG-KHDATQEEIEEASKLSNSHSFIIDLPNGYNTELGEKYTQLSGGQK 1336
Query: 309 QRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNAD 130
QRIAIARAI+RNPK+LLLDE+TSALD+DS K+VQ AL+ + +T+V+AH L T+ NAD
Sbjct: 1337 QRIAIARAIIRNPKILLLDESTSALDADSTKLVQEALENVMKGRTTIVIAHNLLTIQNAD 1396
Query: 129 SIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
IA ++ G++ E+GTH+ELL Y +L Q
Sbjct: 1397 CIAYVRAGQIIERGTHDELLEAEGPYSQLWYNQ 1429
Score = 308 bits (789), Expect = 6e-82
Identities = 196/582 (33%), Positives = 303/582 (51%), Gaps = 15/582 (2%)
Frame = -1
Query: 1722 DYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGF--AMIGEDMLY--YSHLWALSFMFLAV 1555
D +F+ + I G + P ++ + + F +D Y Y + ++SF L +
Sbjct: 176 DKVLMFLGTIAAVINGAAMPTVSLVFGLVVDAFKPTQFNDDPNYDIYDTVRSISFYLLML 235
Query: 1554 FRPLTL--YCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDS 1381
+ + Y + + E+ ++R+R + L ++D + A LS+R+N+D+
Sbjct: 236 GGGVFVLSYLETTLWMIAGERQTSRIRREYLESTLRQEIGWFD--TNKANELSSRINSDT 293
Query: 1380 SNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXA 1201
+ A+ +++G I W++TL + P
Sbjct: 294 VLFEEAIGEKVGRFIHFFSTFVAGFVIGFTKGWQLTLVITSVSPLLAIGGFFTAKMMTQM 353
Query: 1200 IQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAAN 1021
+ A+ + A E + ++RTV + E + S +L+ +KR+ G
Sbjct: 354 TKLGQEAYSRAGGVAEENIGSIRTVATFSGEKLAIDKYSNNLKDARTVGYKRSFFNGLGL 413
Query: 1020 GLSLSCFLFVYSVSFKFGTYLALRKEVAPM--------DTYLVLMTLSMTANMAGSAAAY 865
G L Y+++F +G+ L K + D V + + A G A+
Sbjct: 414 GFVQFVILGTYALAFWYGSTLISNKVTNSVSDRPWTGGDVVSVFFAVIIGATSIGQASPC 473
Query: 864 LPDYKKAVHAAGLIFHLFTYPATM-PFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILN 688
L + + AA IF + + PFS+ K GEI ++V FHY RPD I N
Sbjct: 474 LALFAQGRGAAYKIFQVIDRQSKANPFSTRGIKPETLSGEIEFKDVGFHYPSRPDVPIFN 533
Query: 687 GVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLA 508
G NLK+ PG+T+ LVG SG GKSTIISLLERFY GE+ +D E++ N+ LR +
Sbjct: 534 GFNLKIKPGQTVGLVGDSGGGKSTIISLLERFYDPCQGEILLDGEDIRKFNVRGLRQKIG 593
Query: 507 LVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQ 328
LV+QEP LF +I EN+ YG Q E+E+A + ANA +F+ Q PQG +TLVGE+G Q
Sbjct: 594 LVNQEPVLFATTISENIRYG-KEGATQDEIEEAAKLANAHSFISQLPQGYNTLVGEKGVQ 652
Query: 327 LSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLS 148
+SGGQ+QRIAIARA+++NP +LLLDE+TSALD++S K+VQ ALD + +T+V+AH LS
Sbjct: 653 MSGGQRQRIAIARAVIKNPNILLLDESTSALDAESTKLVQEALDVLMKGRTTIVIAHNLS 712
Query: 147 TVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQ 22
T+ NAD I +K G E+GTH+EL+ K+ +Y+ LV+KQ Q
Sbjct: 713 TIRNADVIIYIKKGVAVERGTHDELMAKQGLYFDLVEKQSHQ 754
>gi|12585141|sp|Q9N0V3|AB11_RABIT Bile salt export pump (ATP-binding
cassette, sub-family B, member 11) (Sister of
P-glycoprotein)
gi|7644354|gb|AAF65552.1| liver bile salt export pump [Oryctolagus
cuniculus]
Length = 1321
Score = 657 bits (1696), Expect = 0.0
Identities = 424/1281 (33%), Positives = 653/1281 (50%), Gaps = 84/1281 (6%)
Frame = -1
Query: 3630 DEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITN 3451
D+KK + +F+ SS + +L +G L + + G QP + FG ++ V +
Sbjct: 36 DKKKSDSVRIGFFQLFRFSSWTDIWLMCMGSLCACIHGIAQPGVLLIFGTMTDVFIDYDT 95
Query: 3450 AINNKTID-PADLEKAYEEYERGMNQVVFHFFLCGC-------------------AYFIF 3331
+ I A + +NQ V + CG A
Sbjct: 96 ELQELKIPGKACVNNTIVWINSSLNQNVTNGTRCGLLDIESEMIRFAGYYAGIGIAVLTT 155
Query: 3330 ASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNE 3151
+Q + ++RK Y ++++ + D S G L+T + + + + +
Sbjct: 156 GYIQICFWGIAAAHQIQKMRKSYFRKIMRMGIGWVDCNSVGKLNTPFSVDFNKINDSSAD 215
Query: 3150 KIALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYA 2971
++A+ I +T G + F W+L I S I I V K T + YA
Sbjct: 216 QLAIFIQGMTSPIFGFLVGFSQWWKLTLVIISVSPLIGLGAAIIGLSVSKFTDYELKAYA 275
Query: 2970 NAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTY---FF 2800
AGS+A + + + +TV + G+K E+ERY + L +++GIR+ ++ G + FF
Sbjct: 276 KAGSVADEVISSMRTVAAFGGEKKEVERYEKNLVFAQRWGIRKGIVMGFFTGYMWCLIFF 335
Query: 2799 CNSL-----NTVVLYVGA----------TMIYSGTLETA--------------------- 2728
C +L + +VL G + G L
Sbjct: 336 CYALAFWYGSKLVLEEGEYSPGALVQIFLSVIIGALNLGNASPCLEAFAAGRAAASSIFE 395
Query: 2727 VVVRDDNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALV 2548
+ R + E Y +E + G I F NV F YP+RP+ ++L +S ++ GE ALV
Sbjct: 396 TIDRKPIIDCMSEDGYKLE-RIKGEIEFHNVTFHYPSRPEVKILNNLSMVIKPGEMTALV 454
Query: 2547 GASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEE 2368
G SG+GKST +QL+ +Y G + ++ D+ +I+ LR IG+V QEPVLF TI E
Sbjct: 455 GPSGAGKSTALQLIHRFYGPTEGMVTVESHDIRSSHIQWLRNQIGIVEQEPVLFFHTIAE 514
Query: 2367 NIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLV 2188
IR+G + ++ ++ A ++ANAY+F+ P+ T+VGE G Q+SGGQKQR+AIAR L+
Sbjct: 515 KIRYGREDATMEDLIQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALI 574
Query: 2187 RNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEI 2008
RNPKILLLD ATSALDNESE +VQ+AL G T + VAHR +TIR A II + G
Sbjct: 575 RNPKILLLDMATSALDNESEAMVQEALSKTQHGHTIVSVAHRPATIRTADVIIGCEHGAA 634
Query: 2007 VEVGNHDELIAKRGVYNDLVQAQLLESHDDHEE---------LPP-------------LA 1894
VE G +EL+ ++GVY LV Q + D EE +P +
Sbjct: 635 VERGTEEELLERKGVYFALVTLQSQRNQGDQEENEKDATEDDIPEKTFSRGNYQDSLRAS 694
Query: 1893 ARQLSQELSPLHSYAIQRSTSNDAGVHDDDMERILDELSKEGAKKSNLREIVKQCRPDYC 1714
RQ S+ ++ + + H++D + D ++E + +++R I+K P++
Sbjct: 695 LRQRSKSQLSYLAHEPPMAVEDHKSTHEED-RKDKDLPAQEDIEPASVRRIMKLNAPEWP 753
Query: 1713 FLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIG-EDMLYYSHLWALSFMFLAVFRPLTL 1537
++ + G+A+ G P+ A L + F++ E+ + L F+ L T
Sbjct: 754 YMLLGSMGAAVNGAVTPLYAFLFSQILGTFSLPDKEEQRSQINGICLLFVTLGCVSFFTQ 813
Query: 1536 YCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVD 1357
+ Q Y F K E L+ RLR F ML ++DD +S L+ RL TD+S V+ A
Sbjct: 814 FLQGYTFAKSGELLTKRLRKFGFRAMLGQDIGWFDDLRNSPGALTTRLATDASQVQGATG 873
Query: 1356 DRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAF 1177
++G ++ + +++A+ A L+ WK+TL ++ FFP D A
Sbjct: 874 SQIGMMVNSFTNVTVAMIIAFLFSWKLTLGIVCFFPFLALSGALQTKMLTGFASRDKQAL 933
Query: 1176 ENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFL 997
E + + EAL N+RTV + E K + L+K +K K+A + G G S
Sbjct: 934 EKAGQITSEALSNIRTVAGIGKERKFIETFEAELEKPYKMAIKKANVYGLCFGFSQCITF 993
Query: 996 FVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFH 817
S S+++G YL + + + V+ + ++A G A++Y P Y KA +A F
Sbjct: 994 IANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRASSYTPSYAKAKISAARFFQ 1053
Query: 816 LF-TYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVG 640
L P +SS+ K + +G+I + +F Y RPD +LNG+++ + P +TLA VG
Sbjct: 1054 LLDRQPPINVYSSAGEKWDNFQGKIDFVDCKFTYPSRPDIQVLNGLSVSMSPRQTLAFVG 1113
Query: 639 PSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIREN 460
SGCGKST I LLERFY G+V ID + +N+ LRSN+ +VSQEP LF CSI++N
Sbjct: 1114 SSGCGKSTSIQLLERFYDPDHGKVMIDGHDSRKVNIQFLRSNIGIVSQEPVLFACSIKDN 1173
Query: 459 LLYG-LTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAI 283
+ YG T+ +P + A + A +FV P+ +T VG +G+QLS G+KQRIAIARAI
Sbjct: 1174 IKYGDNTQEIPMERIIAAAKKAQVHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAI 1233
Query: 282 LRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGK 103
+R+PK+LLLDEATSALD++SEK VQ ALD A E + +V+AHRLST+ N+D IAV+ G
Sbjct: 1234 VRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNSDIIAVMSQGM 1293
Query: 102 VAEQGTHEELLRKRSIYWRLV 40
V E+GTHEEL+ ++ Y++LV
Sbjct: 1294 VIEKGTHEELMVQKGAYYKLV 1314
Score = 296 bits (758), Expect = 2e-78
Identities = 202/606 (33%), Positives = 310/606 (50%), Gaps = 41/606 (6%)
Frame = -1
Query: 3642 LPQSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLV 3463
LP ++ +P+ + R + K ++ ++ LLG + + + G P ++ F SQ+L
Sbjct: 730 LPAQEDIEPASV----RRIMKLNAPEWPYM-LLGSMGAAVNGAVTPLYAFLF---SQILG 781
Query: 3462 TITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTT 3283
T + + +K EE +N + F GC F LQ G+ T
Sbjct: 782 TFS--LPDK-----------EEQRSQINGICLLFVTLGCVSFFTQFLQGYTFAKSGELLT 828
Query: 3282 YRVRKQYISRLLKKDAQYFDSV--STGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTL 3109
R+RK +L +D +FD + S G L+T L + + + +I +++ T+ T+
Sbjct: 829 KRLRKFGFRAMLGQDIGWFDDLRNSPGALTTRLATDASQVQGATGSQIGMMVNSFTNVTV 888
Query: 3108 GTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYK 2929
+AF W+L + F +A SG + + + + AG I + L +
Sbjct: 889 AMIIAFLFSWKLTLGIVCFFPFLALSGALQTKMLTGFASRDKQALEKAGQITSEALSNIR 948
Query: 2928 TVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIY 2749
TV + ++ IE + EL+ K I++A +Y + G + N+ G +I
Sbjct: 949 TVAGIGKERKFIETFEAELEKPYKMAIKKANVYGLCFGFSQCITFIANSASYRYGGYLIS 1008
Query: 2748 SGTLETAVVVRDDNVIEKDET--------------------------DYDVEVEV----- 2662
+ L + V R + + T D + V
Sbjct: 1009 NEGLHFSYVFRVISAVVLSATALGRASSYTPSYAKAKISAARFFQLLDRQPPINVYSSAG 1068
Query: 2661 ------NGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLH 2500
G I F + KF+YP+RPD QVL G+S + + +A VG+SG GKST +QLL
Sbjct: 1069 EKWDNFQGKIDFVDCKFTYPSRPDIQVLNGLSVSMSPRQTLAFVGSSGCGKSTSIQLLER 1128
Query: 2499 YYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLP--EI 2326
+Y+ D G + IDG D +NI+ LR IG+VSQEPVLF +I++NI++G+ +P I
Sbjct: 1129 FYDPDHGKVMIDGHDSRKVNIQFLRSNIGIVSQEPVLFACSIKDNIKYGDNTQEIPMERI 1188
Query: 2325 YGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSA 2146
A +KA +DFV S P+ +T VG +G+QLS G+KQRIAIAR +VR+PKILLLDEATSA
Sbjct: 1189 IAAAKKAQVHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSA 1248
Query: 2145 LDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRG 1966
LD ESE+ VQ AL+ A +GRT IV+AHRLSTI+N+ I VM +G ++E G H+EL+ ++G
Sbjct: 1249 LDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNSDIIAVMSQGMVIEKGTHEELMVQKG 1308
Query: 1965 VYNDLV 1948
Y LV
Sbjct: 1309 AYYKLV 1314
Score = 272 bits (696), Expect = 4e-71
Identities = 171/520 (32%), Positives = 268/520 (50%), Gaps = 7/520 (1%)
Frame = -1
Query: 1542 TLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAA 1363
T Y Q ++G + ++R F ++ + + D +S +L+ + D + + +
Sbjct: 155 TGYIQICFWGIAAAHQIQKMRKSYFRKIMRMGIGWVDC--NSVGKLNTPFSVDFNKINDS 212
Query: 1362 VDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTI 1183
D+L I + + WK+TL ++ P +
Sbjct: 213 SADQLAIFIQGMTSPIFGFLVGFSQWWKLTLVIISVSPLIGLGAAIIGLSVSKFTDYELK 272
Query: 1182 AFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSC 1003
A+ + A E + ++RTV A E K + ++L + ++ I+ G G
Sbjct: 273 AYAKAGSVADEVISSMRTVAAFGGEKKEVERYEKNLVFAQRWGIRKGIVMGFFTGYMWCL 332
Query: 1002 FLFVYSVSFKFGTYLALRK-EVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGL 826
F Y+++F +G+ L L + E +P + +++ + A G+A+ L + AA
Sbjct: 333 IFFCYALAFWYGSKLVLEEGEYSPGALVQIFLSVIIGALNLGNASPCLEAFAAGRAAASS 392
Query: 825 IFHLFTYPATMPFSSSDGKKNIE-KGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLA 649
IF + S DG K KGEI NV FHY RP+ ILN +++ + PG+ A
Sbjct: 393 IFETIDRKPIIDCMSEDGYKLERIKGEIEFHNVTFHYPSRPEVKILNNLSMVIKPGEMTA 452
Query: 648 LVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSI 469
LVGPSG GKST + L+ RFY +G V ++S ++ ++ LR+ + +V QEP LF +I
Sbjct: 453 LVGPSGAGKSTALQLIHRFYGPTEGMVTVESHDIRSSHIQWLRNQIGIVEQEPVLFFHTI 512
Query: 468 RENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIAR 289
E + YG + + +L +A + ANA+NF+ PQ DTLVGE G Q+SGGQKQR+AIAR
Sbjct: 513 AEKIRYGREDATME-DLIQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIAR 571
Query: 288 AILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKN 109
A++RNPK+LLLD ATSALD++SE +VQ AL + V VAHR +T+ AD I ++
Sbjct: 572 ALIRNPKILLLDMATSALDNESEAMVQEALSKTQHGHTIVSVAHRPATIRTADVIIGCEH 631
Query: 108 GKVAEQGTHEELLRKRSIYWRLV-----QKQGIQVETPSD 4
G E+GT EELL ++ +Y+ LV + QG Q E D
Sbjct: 632 GAAVERGTEEELLERKGVYFALVTLQSQRNQGDQEENEKD 671
>gi|15217785|ref|NP_171753.1| multidrug resistance P-glycoprotein,
putative [Arabidopsis thaliana]
gi|25297455|pir||E86155 probable ABC transporter [imported] -
Arabidopsis thaliana
gi|9972378|gb|AAG10628.1| Putative ABC transporter [Arabidopsis
thaliana]
Length = 1278
Score = 657 bits (1694), Expect = 0.0
Identities = 425/1260 (33%), Positives = 651/1260 (50%), Gaps = 60/1260 (4%)
Frame = -1
Query: 3636 QSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTI 3457
+ E+K + + + F SS + L + G + ++ G PFM+ FG++ + +
Sbjct: 32 EKSEEKANTVPFYKLFAFADSS--DVLLMICGSIGAIGNGMSLPFMTLLFGDL---IDSF 86
Query: 3456 TNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYR 3277
NNK I +++V F G A LQ A G+ R
Sbjct: 87 GKNQNNKDIVDV------------VSKVCLKFVYLGLGTLGAAFLQVACWMITGERQAAR 134
Query: 3276 VRKQYISRLLKKDAQYFD-SVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTA 3100
+R Y+ +L++D +FD +TG + ++ + ++ EK+ I V+ F G
Sbjct: 135 IRSTYLKTILRQDIGFFDVETNTGEVVGRMSGDTVLIQDAMGEKVGKFIQLVSTFVGGFV 194
Query: 3099 LAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVC 2920
LAF W L + +A +G + V + + + YA A ++ QT+G+ +TV
Sbjct: 195 LAFIKGWLLTLVMLTSIPLLAMAGAAMALIVTRASSRGQAAYAKAATVVEQTIGSIRTVA 254
Query: 2919 SLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMI---- 2752
S G+K I Y + + + K I++ + GV +F S + ++ G MI
Sbjct: 255 SFTGEKQAINSYKKFITSAYKSSIQQGFSTGLGLGVMFFVFFSSYALAIWFGGKMILEKG 314
Query: 2751 YSGTLETAVVV---------------------------------RDDNVIEKDETDYDVE 2671
Y+G V++ + +I+ + + V
Sbjct: 315 YTGGAVINVIIIVVAGSMSLGQTSPCVTAFAAGQAAAYKMFETIKRKPLIDAYDVNGKVL 374
Query: 2670 VEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYN 2491
++ G+I K+V FSYP RPD ++ G S + +G ALVG SGSGKSTV+ L+ +Y+
Sbjct: 375 EDIRGDIELKDVHFSYPARPDEEIFDGFSLFIPSGATAALVGESGSGKSTVISLIERFYD 434
Query: 2490 IDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALR 2311
SG + IDG++L + +K +R IG+VSQEPVLF+++I ENI +G N ++ EI A
Sbjct: 435 PKSGAVLIDGVNLKEFQLKWIRSKIGLVSQEPVLFSSSIMENIAYGKENATVEEIKAATE 494
Query: 2310 KANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNES 2131
ANA F+ P+G+ T+VGE GTQLSGGQKQRIAIAR ++++P+ILLLDEATSALD ES
Sbjct: 495 LANAAKFIDKLPQGLDTMVGEHGTQLSGGQKQRIAIARAILKDPRILLLDEATSALDAES 554
Query: 2130 EQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIA-KRGVYND 1954
E+VVQ+AL+ RTT++VAHRLST+RNA I V+ +G++VE G+H EL+ G Y+
Sbjct: 555 ERVVQEALDRVMVNRTTVIVAHRLSTVRNADMIAVIHRGKMVEKGSHSELLKDSEGAYSQ 614
Query: 1953 LVQAQLLESHDDHEELPPLAARQLSQ------------ELSPLHSY-AIQRSTSNDAGVH 1813
L++ Q + EL ++ + S S HS + +T D G H
Sbjct: 615 LIRLQEINKDVKTSELSSGSSFRNSNLKKSMEGTSSVGNSSRHHSLNVLGLTTGLDLGSH 674
Query: 1812 DDDMERILDE---LSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIV 1642
+ DE S+E K +L I +P+ L + +AI G +P+ LI
Sbjct: 675 SQRAGQ--DETGTASQEPLPKVSLTRIAALNKPEIPVLLLGTVAAAINGAIFPLFGILIS 732
Query: 1641 RTYEGFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSH 1462
R E F ++ S WA+ F+ L V + Q Y F +L R+R F
Sbjct: 733 RVIEAFFKPAHELKRDSRFWAIIFVALGVTSLIVSPTQMYLFAVAGGKLIRRIRSMCFEK 792
Query: 1461 MLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCW 1282
+ + A++D+P +S+ + RL+ D++ ++A V D L + V + + + A W
Sbjct: 793 AVHMEVAWFDEPQNSSGTMGARLSADATLIRALVGDALSLAVQNVASAASGLIIAFTASW 852
Query: 1281 KMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDK 1102
++ L +L+ P + +E +++ A +A+ ++RTV + E+K
Sbjct: 853 ELALIILVMLPLIGINGFVQVKFMKGFSADAKSKYEEASQVANDAVGSIRTVASFCAEEK 912
Query: 1101 IMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTY 922
+M + + + K K+ I G G S VY+ SF G L + + +
Sbjct: 913 VMQMYKKQCEGPIKDGIKQGFISGLGFGFSFFILFCVYATSFYAGARLVEDGKTTFNNVF 972
Query: 921 LVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGK--KNIEKGE 748
V L+M A ++ + PD KA AA IF + + + S G +N+ KG+
Sbjct: 973 QVFFALTMAAIGISQSSTFAPDSSKAKVAAASIFAIIDRKSKIDSSDETGTVLENV-KGD 1031
Query: 747 IIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEV 568
I ++ F Y RPD I + L + GKT+ALVG SG GKST+ISLL+RFY G +
Sbjct: 1032 IELRHLSFTYPARPDIQIFRDLCLTIRAGKTVALVGESGSGKSTVISLLQRFYDPDSGHI 1091
Query: 567 KIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLY--GLTRSVPQLELEKALQTAN 394
+D ++ + L LR + LV QEP LFN +IR N+ Y G + + E+ A + AN
Sbjct: 1092 TLDGVELKKLQLKWLRQQMGLVGQEPVLFNDTIRANIAYGKGSEEAATESEIIAAAELAN 1151
Query: 393 AFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKV 214
A F+ QG DT+VGERG QLSGGQKQR+AIARAI++ PK+LLLDEATSALD++SE+V
Sbjct: 1152 AHKFISSIQQGYDTVVGERGIQLSGGQKQRVAIARAIVKEPKILLLDEATSALDAESERV 1211
Query: 213 VQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLR-KRSIYWRLVQ 37
VQ+ALD +T+VVAHRLST+ NAD IAV+KNG +AE+GTHE L++ + +Y LVQ
Sbjct: 1212 VQDALDRVMVNRTTIVVAHRLSTIKNADVIAVVKNGVIAEKGTHETLIKIEGGVYASLVQ 1271
>gi|48094917|ref|XP_394305.1| similar to ENSANGP00000021663 [Apis
mellifera]
Length = 5485
Score = 655 bits (1690), Expect = 0.0
Identities = 432/1311 (32%), Positives = 659/1311 (49%), Gaps = 121/1311 (9%)
Frame = -1
Query: 3585 FKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEK- 3409
F+ ++C E L G++ +TG C P + +GE + +LV + N T P + K
Sbjct: 3730 FRFATCGELMLIFGGLIMGTLTGLCIPISTIQYGEFTTLLVD--RNMKNHTSTPTLIMKW 3787
Query: 3408 -----------AYEEYERGMNQVVFHFFLCGCAY----FIFASLQHAIMKYVGDNTTYRV 3274
Y+E + F + A F+FA ++ RV
Sbjct: 3788 FGGGKVLGSNSTYKERMEALYDDSVAFGVSSAALSTFQFVFAVFTVDLLNVAASRQIVRV 3847
Query: 3273 RKQYISRLLKKDAQYFD-SVSTGHLSTVLNDN---------------------------- 3181
RK ++ +L++D ++D + ST S + + N
Sbjct: 3848 RKMFLRSVLRQDMTWYDINTSTNFASRITDGNNLVNNLRDDAVFCHNGDRRGNHGGFDLE 3907
Query: 3180 --------------LERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLG 3043
L++ ++ EK+ + + F ++F W+L + +
Sbjct: 3908 DECKRDRVDGGAKDLDKMKDGIGEKLGVFTYLMVSFISSIIISFVYGWKLTLVVLSCAPI 3967
Query: 3042 IAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAG 2863
I + + + T ++ T Y AGS+A + LGA +TV + NG++ E+ RY E+L
Sbjct: 3968 IVIATAVVAKVQSSLTAQELTAYGQAGSVAEEVLGAIRTVIAFNGEQKEVNRYAEKLIPA 4027
Query: 2862 EKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIY---------------------- 2749
EK GI+R + + GV +F + + G +I
Sbjct: 4028 EKTGIKRGMWSGVGGGVMWFIIYISYAIAFWYGVQLILEDRPKEVKEYTPAVLVIVFFGV 4087
Query: 2748 ----------SGTLETAVVVRDD-----NVIEKDETDYDVEVE------VNGNISFKNVK 2632
S LE V R V+++ T + E VNG I FKNV
Sbjct: 4088 LAGAQNMGLTSPHLEAFAVARGSAAAIFQVLDRVPTIDSLSKEGQKLPAVNGEIEFKNVH 4147
Query: 2631 FSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDL 2452
F YP R D +VL+G++ + GE +ALVG SG GKST +QL+ Y+ G + +DG+D+
Sbjct: 4148 FQYPARKDVKVLQGLNLTINRGETVALVGGSGCGKSTCLQLIQRLYDPHKGQVLLDGVDV 4207
Query: 2451 NDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPK 2272
+ +N++ LR IGVV QEPVLF+TTI ENIR+GN +++ E+ A ++ANA+DF+ P+
Sbjct: 4208 SKLNVQWLRSHIGVVGQEPVLFDTTIRENIRYGNDSITEEEMIKAAKEANAHDFISKLPE 4267
Query: 2271 GIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQ 2092
+ VGERG+Q+SGGQKQRIAIAR LVR P ILLLDEATSALD SE VQ+AL+ AS+
Sbjct: 4268 AYDSPVGERGSQMSGGQKQRIAIARALVRRPAILLLDEATSALDLHSEATVQRALDAASK 4327
Query: 2091 GRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLESHDDH- 1915
GRTTIVV HRLSTI NA +I+ ++ G++VE G H+EL+A Y LV A +
Sbjct: 4328 GRTTIVVTHRLSTITNADRIVFIKDGQVVEQGTHEELLALGKHYYGLVSADASATARAKA 4387
Query: 1914 -------------EELPPLAARQLSQELSPLHSYAIQRSTSNDAGVHDDDMERILDELSK 1774
++ PPL RQ S +HS+ + + +++ + L+E
Sbjct: 4388 TASAAKTVTAAIPKQKPPL-KRQFS--TLSMHSHRLSLAGASETSANQ------LEE--H 4436
Query: 1773 EGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYY 1594
E + + I +P++ + I +A+ G S+P A L Y + ++ +
Sbjct: 4437 EKPYDAPMMRIFGLNKPEWPYNIIGCLAAAMVGASFPAFAVLFGEVYYVLGLQDDEEVRR 4496
Query: 1593 SHL-WALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHS 1417
+ +++ F+ + V L + Q Y FG +++TR+R +F+ ML +YD+ +S
Sbjct: 4497 ETVNFSILFLVVGVVTGLGTFLQMYMFGLAGVRMTTRIRKITFAAMLKQEMGWYDEDTNS 4556
Query: 1416 ATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXX 1237
L RL++D+ V+ A R+G ++ + + + I + Y WKMTL ++ P
Sbjct: 4557 VGALCARLSSDAGAVQGATGTRVGAILQALSTLVLGIGLSMYYTWKMTLVSVVSIPLVLG 4616
Query: 1236 XXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKS 1057
++ E + R AIEA+ N+RTV +L E+ + L + ++
Sbjct: 4617 AVFFEARVMSGQGLQEKKKMEAATRIAIEAISNIRTVASLGKEEAFLQRYCSELDHVAEA 4676
Query: 1056 YFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGS 877
R ++G + F Y++S +G L + + D V L + M G
Sbjct: 4677 TRIRQRLRGLVFSCGQTTPFFGYALSLYYGGALVATEGLNYQDVIKVSEALIFGSWMLGQ 4736
Query: 876 AAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIE---KGEIIGENVQFHYDQRP 706
A A+ P++ A +AG IF L + K+++ G I V+FHY RP
Sbjct: 4737 ALAFAPNFNTAKISAGRIFKLLDRVPEIASPPDSEDKDLDWKADGLIQFSKVEFHYPTRP 4796
Query: 705 DRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNH 526
+ IL G+NL V PG+ +ALVG SGCGKST I LL+R Y + G V +D ++ ++L +
Sbjct: 4797 EMQILQGLNLIVKPGQMVALVGQSGCGKSTCIQLLQRLYDPISGTVTMDRRDISSVSLRN 4856
Query: 525 LRSNLALVSQEPTLFNCSIRENLLYGLT-RSVPQLELEKALQTANAFNFVFQFPQGLDTL 349
LRS L +V QEP LF+ +I EN+ YG R VP E+ +A + +N +FV P G DT
Sbjct: 4857 LRSQLGVVGQEPVLFDRTIAENIAYGDNFRLVPMDEIIEAAKKSNIHSFVSSLPLGYDTR 4916
Query: 348 VGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTV 169
+G +G QLSGGQKQRIAIARA++RNP+VLLLDEATSALD+ SEKVVQ ALD A E + +
Sbjct: 4917 LGSKGTQLSGGQKQRIAIARALVRNPRVLLLDEATSALDTQSEKVVQAALDKAMEGRTCI 4976
Query: 168 VVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQVE 16
+AHRL+T+ NAD I VL+ G VAE GTH++L+ +Y L Q +E
Sbjct: 4977 TIAHRLATIRNADVICVLEKGTVAEMGTHDDLIAADGLYAHLHALQEAAME 5027
Score = 299 bits (765), Expect = 4e-79
Identities = 206/597 (34%), Positives = 305/597 (50%), Gaps = 48/597 (8%)
Frame = -1
Query: 3549 LLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQVV 3370
++G L + M G P + FGEV VL + EE R
Sbjct: 4459 IIGCLAAAMVGASFPAFAVLFGEVYYVLGLQDD----------------EEVRRETVNFS 4502
Query: 3369 FHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQYFD--SVSTGHLST 3196
F + G + LQ + G T R+RK + +LK++ ++D + S G L
Sbjct: 4503 ILFLVVGVVTGLGTFLQMYMFGLAGVRMTTRIRKITFAAMLKQEMGWYDEDTNSVGALCA 4562
Query: 3195 VLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINS 3016
L+ + + ++ I+ ++ LG L+ Y W++ + S+ +
Sbjct: 4563 RLSSDAGAVQGATGTRVGAILQALSTLVLGIGLSMYYTWKMTLVSVV-SIPLVLGAVFFE 4621
Query: 3015 AGVMKTTGKQNTHYANAGS-IAFQTLGAYKTVCSLNGQKTEIERYTEELK-AGEKYGIR- 2845
A VM G Q A + IA + + +TV SL ++ ++RY EL E IR
Sbjct: 4622 ARVMSGQGLQEKKKMEAATRIAIEAISNIRTVASLGKEEAFLQRYCSELDHVAEATRIRQ 4681
Query: 2844 --RALMYSISRGVTYFFCNSLNTVVLYVGATMIYSGTLETAVVVRDDNVI---------- 2701
R L++S + T FF +L+ LY G ++ + L V++ +
Sbjct: 4682 RLRGLVFSCGQ-TTPFFGYALS---LYYGGALVATEGLNYQDVIKVSEALIFGSWMLGQA 4737
Query: 2700 -----------------------------EKDETDYDVEVEVNGNISFKNVKFSYPTRPD 2608
D D D++ + +G I F V+F YPTRP+
Sbjct: 4738 LAFAPNFNTAKISAGRIFKLLDRVPEIASPPDSEDKDLDWKADGLIQFSKVEFHYPTRPE 4797
Query: 2607 AQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRL 2428
Q+L+G++ V+ G+ +ALVG SG GKST +QLL Y+ SG + +D D++ ++++ L
Sbjct: 4798 MQILQGLNLIVKPGQMVALVGQSGCGKSTCIQLLQRLYDPISGTVTMDRRDISSVSLRNL 4857
Query: 2427 RRVIGVVSQEPVLFNTTIEENIRFGN--PNVSLPEIYGALRKANAYDFVCSFPKGIKTIV 2254
R +GVV QEPVLF+ TI ENI +G+ V + EI A +K+N + FV S P G T +
Sbjct: 4858 RSQLGVVGQEPVLFDRTIAENIAYGDNFRLVPMDEIIEAAKKSNIHSFVSSLPLGYDTRL 4917
Query: 2253 GERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIV 2074
G +GTQLSGGQKQRIAIAR LVRNP++LLLDEATSALD +SE+VVQ AL+ A +GRT I
Sbjct: 4918 GSKGTQLSGGQKQRIAIARALVRNPRVLLLDEATSALDTQSEKVVQAALDKAMEGRTCIT 4977
Query: 2073 VAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLESHDDHEELP 1903
+AHRL+TIRNA I V++KG + E+G HD+LIA G+Y L Q E+ +H +LP
Sbjct: 4978 IAHRLATIRNADVICVLEKGTVAEMGTHDDLIAADGLYAHLHALQ--EAAMEHNDLP 5032
Score = 75.1 bits (183), Expect = 1e-11
Identities = 65/262 (24%), Positives = 122/262 (45%), Gaps = 6/262 (2%)
Frame = -1
Query: 2760 TMIYSGTLETAVVVRDDNVIEKDETDYDVEVEVNGN---ISFKNVKFSYPT-RPDAQVLK 2593
T+ + G L + DE + VN + F V+ Y T + + +
Sbjct: 2541 TIAFDGFLYAVIGYLIARYTNSDEESNATSLTVNEKQTGVRFDGVRKVYNTDQGEIVAVD 2600
Query: 2592 GISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIG 2413
+ + GE +L+G +G+GK+T++++L +G I ++G + + IG
Sbjct: 2601 DFTLKLSEGEVTSLLGRNGAGKTTIIKMLTGMLAPTTGEICLNGEE-------GCKPDIG 2653
Query: 2412 VVSQEPVLFNT-TIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQ 2236
V Q+ VL T T E++ F E Y +++ N + + S G + E +
Sbjct: 2654 VCPQDNVLIGTLTPREHLLFYAKLKRSKEEYANVQR-NVDEMLTSLELGSQE--HEPVYR 2710
Query: 2235 LSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLS 2056
LSGG K+R+ +A + +PK+++LDE + +D + + + + ++ GRT I+ H L
Sbjct: 2711 LSGGTKRRLCVALAFLGSPKLVILDEPGAGVDPAARRRIWRLIDQHRTGRTVILSTHHLD 2770
Query: 2055 TIRNAS-KIIVMQKGEIVEVGN 1993
S ++VM KG+I+ G+
Sbjct: 2771 EADTLSDTVVVMHKGKILCTGS 2792
Score = 62.0 bits (149), Expect = 1e-07
Identities = 72/328 (21%), Positives = 140/328 (41%), Gaps = 12/328 (3%)
Frame = -1
Query: 987 SVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFT 808
S SF +G A RKEV + M + + S L + G ++ +
Sbjct: 2498 STSFCYGCLYAARKEVQGVGLTWSAMWEESSPGDSMSLGLIL----LTIAFDGFLYAVIG 2553
Query: 807 YPATMPFSSSDGKKNIEKGEIIGENVQFHYD--------QRPDRMILNGVNLKVDPGKTL 652
Y +++SD + N + + +D + + + ++ LK+ G+
Sbjct: 2554 YLIAR-YTNSDEESNATSLTVNEKQTGVRFDGVRKVYNTDQGEIVAVDDFTLKLSEGEVT 2612
Query: 651 ALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNC- 475
+L+G +G GK+TII +L GE+ ++ E + ++ + Q+ L
Sbjct: 2613 SLLGRNGAGKTTIIKMLTGMLAPTTGEICLNGEE-------GCKPDIGVCPQDNVLIGTL 2665
Query: 474 SIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGA--QLSGGQKQRI 301
+ RE+LL+ +L+ K + AN V + L+ E +LSGG K+R+
Sbjct: 2666 TPREHLLF-----YAKLKRSKE-EYANVQRNVDEMLTSLELGSQEHEPVYRLSGGTKRRL 2719
Query: 300 AIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTV-VNADSI 124
+A A L +PK+++LDE + +D + + + +D + ++ H L +D++
Sbjct: 2720 CVALAFLGSPKLVILDEPGAGVDPAARRRIWRLIDQHRTGRTVILSTHHLDEADTLSDTV 2779
Query: 123 AVLKNGKVAEQGTHEELLRKRSIYWRLV 40
V+ GK+ G+ L +RL+
Sbjct: 2780 VVMHKGKILCTGSPLSLKMMHGRGYRLL 2807
Score = 57.0 bits (136), Expect = 3e-06
Identities = 47/216 (21%), Positives = 103/216 (46%), Gaps = 5/216 (2%)
Frame = -1
Query: 2598 LKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRV 2419
++ +S V+ G+C L+G +G+GKST ++L +G I + G ++
Sbjct: 3446 VQNLSIGVEAGKCFGLLGTNGAGKSTTFRMLTTEIIPTAGRIIVRGKEIGS--------- 3496
Query: 2418 IGVVSQEPVLFNTTIEENIRFGNPNVSLP---EIYGALRKANAYDFVCSFPKGIKTIVGE 2248
G + V + + F +P+ L E+ G A + +K +
Sbjct: 3497 -GPLCNGEVGYCPQSDGIDGFLSPHQCLTIHGEVCGLSNVPKAVESALKRLDLLK-YAHK 3554
Query: 2247 RGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVV- 2071
R + LSGG K+++ A +++ ++L+DE TS +D ++ +V K +++ ++ +T +++
Sbjct: 3555 RVSSLSGGNKRKLCTALSVMAPVPVVLMDEPTSGMDPATKDLVTKTIKHLTRNQTCVILT 3614
Query: 2070 AHRLSTIRN-ASKIIVMQKGEIVEVGNHDELIAKRG 1966
+H ++ N +++ ++ K + +G L K G
Sbjct: 3615 SHSVADCENVCNRVGILAKAGLRCIGTPQHLKHKFG 3650
Score = 43.9 bits (102), Expect = 0.029
Identities = 46/216 (21%), Positives = 94/216 (43%), Gaps = 6/216 (2%)
Frame = -1
Query: 693 LNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSN 514
+ +++ V+ GK L+G +G GKST +L G + + + + L +
Sbjct: 3446 VQNLSIGVEAGKCFGLLGTNGAGKSTTFRMLTTEIIPTAGRIIVRGKEIGSGPLCNGEVG 3505
Query: 513 LALVSQEPTLF----NCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLV 346
S F C + GL+ +VP+ +E AL+ + + +
Sbjct: 3506 YCPQSDGIDGFLSPHQCLTIHGEVCGLS-NVPKA-VESALKRLDLLKYAHK--------- 3554
Query: 345 GERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVV 166
R + LSGG K+++ A +++ V+L+DE TS +D ++ +V + + + V+
Sbjct: 3555 --RVSSLSGGNKRKLCTALSVMAPVPVVLMDEPTSGMDPATKDLVTKTIKHLTRNQTCVI 3612
Query: 165 V-AHRLSTVVN-ADSIAVLKNGKVAEQGTHEELLRK 64
+ +H ++ N + + +L + GT + L K
Sbjct: 3613 LTSHSVADCENVCNRVGILAKAGLRCIGTPQHLKHK 3648
>gi|22026798|ref|NP_523740.2| CG8523-PA [Drosophila melanogaster]
gi|21645421|gb|AAF58271.2| CG8523-PA [Drosophila melanogaster]
Length = 1287
Score = 654 bits (1688), Expect = 0.0
Identities = 418/1263 (33%), Positives = 657/1263 (51%), Gaps = 62/1263 (4%)
Frame = -1
Query: 3633 SDEKKPSQICSFIRVV-----FKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQV 3469
SDE+ SQ ++ V F+ ++ ++ L+++G+L ++ TG P S FG ++
Sbjct: 30 SDEEDGSQYHEDVKQVSYFQLFRYATKKDRALYVIGLLSAVATGLTTPANSLIFGNLAND 89
Query: 3468 LVTITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDN 3289
++ + + + AD + ++ + Q G + + L Y +
Sbjct: 90 MIDLGGLLESGKSYRADDAISTLLLDK-VRQFSLQNTYIGIIMLVCSYLSITCFNYAAHS 148
Query: 3288 TTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTL 3109
+R ++ +L +D +++D +G +++ +N++L + + EK+ + + ++ F
Sbjct: 149 QILTIRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVG 208
Query: 3108 GTALAFYTDWRLASYGIFFSLGIAFSGF-INSAGVMKTTGKQNTHYANAGSIAFQTLGAY 2932
LAF W+L S SL + F + + + K+ T YA A +A L
Sbjct: 209 SLVLAFVKGWQL-SLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGI 267
Query: 2931 KTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMI 2752
+TV + G+ E+ Y E + A + I+R + I G+ +FF + + + G ++
Sbjct: 268 RTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLWFFIYASYALAFWYGVGLV 327
Query: 2751 YSG---------------TLETAVVVRDDNV-----------------------IEKDET 2686
G T+ +V++ N+ IE+
Sbjct: 328 IKGYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPE 387
Query: 2685 DYDVEVEVNG------NISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKS 2524
++ E I FK V+F YPTRP+ +L ++ + G+ +ALVG SG GKS
Sbjct: 388 INPIDGEGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKS 447
Query: 2523 TVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPN 2344
T +QL+ +Y+ +GN+ +G +L D++I LR IGVV QEP+LF T+I ENIR+G +
Sbjct: 448 TCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGRED 507
Query: 2343 VSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLL 2164
+ EI A ANA F+ PKG T+VGERG QLSGGQKQRIAIAR L+R+P+ILLL
Sbjct: 508 ATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLL 567
Query: 2163 DEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDE 1984
DEATSALD SE VQ ALE S GRTTI+VAHRLST+R A +I+V+ KGE+VE G H E
Sbjct: 568 DEATSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQE 627
Query: 1983 LIAKRGVYNDLVQAQLLESHDDHEELPPLAARQLSQELSPLHSYAIQRSTSNDAGVHDDD 1804
L+ + Y +LV QL E DD L P + ++ I+ + ++ D+D
Sbjct: 628 LMELKDHYFNLVTTQLGE--DDGSVLSPTGDIYKNFDIKDEDEEEIKVLSEDE----DED 681
Query: 1803 MERILDELSKEGAKK--------SNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQL 1648
+ + DE +K+ KK + E++K +P++ + + S I G + PI A L
Sbjct: 682 V-MVTDEKNKKKKKKKVKDPNEVKPMLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVL 740
Query: 1647 IVRTYEGFAMIGEDMLY--YSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIK 1474
+ ++ D S+ ++L F+ + + + Q Y+FG E+L+ RLR
Sbjct: 741 FGSILQILSVKDNDQYVRENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGL 800
Query: 1473 SFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTAS 1294
F ML A++DD + L RL+ D++ V+ A R+G ++ ++ +++ I +
Sbjct: 801 MFEAMLRQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSM 860
Query: 1293 LYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALN 1114
Y W + L L F P EN + A+E + N+RTV +L
Sbjct: 861 YYEWSLGLVALAFTPFILIAFYMQRTLMAKENMGSAKTMENCTKLAVEVVSNIRTVASLG 920
Query: 1113 LEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAP 934
E+ L + + +G GL+ S F Y+ +GT+ + + +
Sbjct: 921 REEMFHQNYIGMLIPAVEISKRNTHFRGLVYGLARSLMFFAYAACMYYGTWCVIHRGILF 980
Query: 933 MDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIF-HLFTYPATMPFSSSDGKKNIE 757
D + V L M +A A+ P+ +K V AA IF L P+ +
Sbjct: 981 GDVFKVSQALIMGTASIANALAFAPNMQKGVSAAKTIFTFLRRQPSIVDRPGVSRDPWHS 1040
Query: 756 KGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVD 577
+G + + V+F Y R + +L G+ L V G+ +ALVGPSGCGKST I L++RFY +
Sbjct: 1041 EGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDE 1100
Query: 576 GEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYG-LTRSVPQLELEKALQT 400
G ID +V ++++ +LR+ L +VSQEP LF+ +IREN+ YG R+V E+ A +
Sbjct: 1101 GATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARNVTDQEIISACKK 1160
Query: 399 ANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSE 220
+N F+ P G DT +GE+GAQLSGGQKQRIAIARA++RNPK++LLDEATSALD++SE
Sbjct: 1161 SNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESE 1220
Query: 219 KVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLV 40
KVVQ+ALD ASE +T+ +AHRLSTVV++D I V +NG V E G H++LL R +Y+ L
Sbjct: 1221 KVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLLANRGLYYTLY 1280
Query: 39 QKQ 31
+ Q
Sbjct: 1281 KLQ 1283
>gi|27368859|emb|CAD59587.1| MDR-like ABC transporter [Oryza sativa
(japonica cultivar-group)]
Length = 1264
Score = 654 bits (1688), Expect = 0.0
Identities = 413/1242 (33%), Positives = 648/1242 (51%), Gaps = 58/1242 (4%)
Frame = -1
Query: 3588 VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEK 3409
+F+ + + L ++G + +L G QP M+ FG V T+
Sbjct: 36 LFRYADRLDVLLMVVGTVGALGNGISQPLMTVLFGNVINSFGANTSG------------- 82
Query: 3408 AYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQY 3229
R + +VV +F G + + LQ + G+ + R+R Y+ +L++D +
Sbjct: 83 ---SVLRSVTKVVLNFIYLGIGTSVASFLQVSCWTMAGERQSARIRSLYLKAVLRQDITF 139
Query: 3228 FDS-VSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFF 3052
FD+ ++TG + ++ + + EK ++ ++ F G +AF W L +
Sbjct: 140 FDTEMTTGEAVSRMSSDTLLIQGALGEKGGKLVELLSSFIGGFIIAFTRGWLLTLVMLTS 199
Query: 3051 SLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEEL 2872
IA + +++ + + + K+ T Y++AG QT+G+ +TV S NG+K I Y +
Sbjct: 200 LPLIAIASAVSAQALTRVSSKRQTSYSDAGDTVEQTIGSIRTVVSFNGEKKAIAMYRNFI 259
Query: 2871 KAGEKYGIRRALMYSI-----------SRGVTYFFCNSL-----------NTVVLYV--G 2764
K K I ++ S G+ +++ L T++ V G
Sbjct: 260 KKSYKATIEEGIITGFGMGSVMCVVFGSYGLAFWYGGKLIIEKGYTGGKIMTILFAVLTG 319
Query: 2763 ATMIYSGTLETAVVVRDDNV-------------IEKDETDYDVEVEVNGNISFKNVKFSY 2623
A+ + + T A VV + I+ D+ + V ++NG+I K+V F Y
Sbjct: 320 ASSLGNATPAVAAVVEGQSAAYNLFKTIERKPEIDSDDNNGMVLEDMNGDIELKDVYFRY 379
Query: 2622 PTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDM 2443
P RP+ +L G+S V +G +A+VG SGSGKSTV+ L+ +Y+ SG + IDG+ + +
Sbjct: 380 PARPEQLILDGLSLQVASGTTMAIVGESGSGKSTVISLVERFYDPQSGEVLIDGISIKKL 439
Query: 2442 NIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIK 2263
+ +R IG+VSQEP+LF +I++NI +G + +L EI A ANA +F+ P G
Sbjct: 440 RLDWIRGKIGLVSQEPLLFMASIKDNIIYGKKDATLEEIKRAAELANAANFIDKLPNGYD 499
Query: 2262 TIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRT 2083
T+VG+RGTQLSGGQKQRIAIAR ++++PKILLLDEATSALD ESE++VQ+AL RT
Sbjct: 500 TLVGQRGTQLSGGQKQRIAIARAILKDPKILLLDEATSALDVESERIVQEALNRMMVERT 559
Query: 2082 TIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIA-KRGVYNDLVQAQLLESH-DDHEE 1909
T+VVAHRLST+RN I V++KG+IVE G HD L+ G Y+ L++ Q E+H D+ +
Sbjct: 560 TLVVAHRLSTVRNVDCITVVRKGKIVEQGPHDALVKDPDGAYSQLIRLQ--ETHRDERHK 617
Query: 1908 LPPLAARQLSQE---------LSPLHSYAIQRSTSNDAGVHDDDM----ERI--LDELSK 1774
LP ++ S LS + Y+ + +H+D M +++ D
Sbjct: 618 LPDSRSKSTSLSFRRSRTKDFLSKSNRYSFKSPLGLPVDIHEDGMTSEQQKVDHSDNSDS 677
Query: 1773 EGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYY 1594
+ KK+ + +P+ L + +++ GV P+ ++ + F + +
Sbjct: 678 KAIKKTPFGRLFNLNKPEVPVLLLGSIAASVHGVILPLYGIIMPGVLKSFYEPPDQLRKD 737
Query: 1593 SHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSA 1414
S WAL + L V +++ +Y+ FG +L R+R SF ++ A++D P++S+
Sbjct: 738 SRFWALMSVVLGVACLISIPAEYFLFGIAGGKLIQRVRTLSFQRIMHQEVAWFDKPSNSS 797
Query: 1413 TRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXX 1234
L RL+ D+ NV+ V D L ++ V + A W++ L + P
Sbjct: 798 GALGTRLSVDALNVRRLVGDNLALIVQAVATLITGFAIAFAADWRLALIITCVIPLVGAQ 857
Query: 1233 XXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSY 1054
+E +E++N+ A +A+ ++RTV + E +++++ ++ + + K
Sbjct: 858 GYAQVKFLKGFSEESKEMYEDANQVAADAVGSIRTVASFCSEKRVVAIYNKKCEALRKQG 917
Query: 1053 FKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSA 874
+ I+ G S Y + F G + + D + V L + A +
Sbjct: 918 IRSGIVGGIGLSFSNLMLYLTYGLCFYVGAKFVSQGKTTFSDVFKVFFALVLAAVGVSQS 977
Query: 873 AAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDG--KKNIEKGEIIGENVQFHYDQRPDR 700
+A + KA +A IF + + + SS +G +N+ G I NV F Y RPD
Sbjct: 978 SALSTNATKARDSAISIFSIIDRKSRIDSSSDEGAIMENV-TGSIDFNNVSFKYPSRPDV 1036
Query: 699 MILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLR 520
I + L + KT+ALVG SG GKSTII+LLERFY G + +D + + ++ LR
Sbjct: 1037 QIFSDFTLHIPSQKTIALVGESGSGKSTIIALLERFYDPDSGNISLDGVEIRSLKVSWLR 1096
Query: 519 SNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGE 340
+ LV QEP LFN +IR N+ YG V + E+ + ANA FV PQG DT+VGE
Sbjct: 1097 DQMGLVGQEPVLFNDTIRANITYGKHSEVTEEEITAVAKAANAHEFVSSLPQGYDTVVGE 1156
Query: 339 RGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVA 160
+G QLSGGQKQR+AIARAIL++PK+LLLDEATSALD++SE+VVQ+ALD +T+VVA
Sbjct: 1157 KGVQLSGGQKQRVAIARAILKDPKILLLDEATSALDAESERVVQDALDRVMVNRTTIVVA 1216
Query: 159 HRLSTVVNADSIAVLKNGKVAEQGTHEELLR-KRSIYWRLVQ 37
HRLST+ AD IAVLK GK+AE+G HE LLR K Y LVQ
Sbjct: 1217 HRLSTIKGADMIAVLKEGKIAEKGKHEALLRIKDGAYASLVQ 1258
>gi|15237456|ref|NP_199466.1| ABC transporter family protein
[Arabidopsis thaliana]
Length = 1248
Score = 652 bits (1681), Expect = 0.0
Identities = 419/1224 (34%), Positives = 641/1224 (52%), Gaps = 51/1224 (4%)
Frame = -1
Query: 3588 VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEK 3409
+F + ++ L ++G L ++ G QPFMS G++ V +D +
Sbjct: 23 LFTFADRYDIVLMVIGTLSAMANGLTQPFMSILMGQLINVFGF------------SDHDH 70
Query: 3408 AYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQY 3229
++E +++V F + + LQ + G+ + R+R+ Y+ +L++D +
Sbjct: 71 VFKE----VSKVAVKFLYLAAYAGVVSFLQVSCWMVTGERQSTRIRRLYLKTILRQDIGF 126
Query: 3228 FDS-VSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFF 3052
FD+ +TG + ++ + ++ EK+ V+ F G +AF +L +
Sbjct: 127 FDTETNTGEVIGRMSGDTILIQDSMGEKVGKFTQLVSSFVGGFTVAFIVGMKLTLALLPC 186
Query: 3051 SLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEEL 2872
I +G + + K + Y AG++ Q +G+ +TV + G+K + +Y ++L
Sbjct: 187 VPLIVGTGGAMTYIMSKKAQRVQLAYTEAGNVVQQAVGSIRTVVAFTGEKQSMGKYEKKL 246
Query: 2871 KAGEKYGIRRALMYSISRGV-------TYFFC----------------------NSLNTV 2779
+ K +++ L + G+ TY F S+ T
Sbjct: 247 EIAYKSMVKQGLYSGLGIGIMMVVVYCTYGFAIWYGARQIIEKGYTGGQVMNVITSILTG 306
Query: 2778 VLYVGATM--IYSGTLETAVVVRDDNVIEK----DETDYDVEV--EVNGNISFKNVKFSY 2623
+ +G T+ + S TA + I++ D D EV E+ G+I ++V F Y
Sbjct: 307 GMALGQTLPSLNSFAAGTAAAYKMFETIKRKPKIDAYDMSGEVLEEIKGDIELRDVYFRY 366
Query: 2622 PTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDM 2443
P RPD Q+ G S V NG +ALVG SGSGKSTV+ L+ +Y+ +SG + IDG+DL
Sbjct: 367 PARPDVQIFVGFSLTVPNGMTVALVGQSGSGKSTVISLIERFYDPESGEVLIDGIDLKKF 426
Query: 2442 NIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIK 2263
+K +R IG+VSQEP+LF TTI ENI +G + S EI AL+ ANA +F+ P+G++
Sbjct: 427 QVKWIRSKIGLVSQEPILFATTIRENIVYGKKDASDQEIRTALKLANASNFIDKLPQGLE 486
Query: 2262 TIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRT 2083
T+VGE GTQLSGGQKQRIAIAR +++NPKILLLDEATSALD ESE++VQ AL RT
Sbjct: 487 TMVGEHGTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAESERIVQDALVKLMLSRT 546
Query: 2082 TIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIA-KRGVYNDLVQAQLLESHDDHEEL 1906
T+VVAHRL+TIR A I V+Q+G+++E G HDE+I G Y+ LV+ Q ++ +
Sbjct: 547 TVVVAHRLTTIRTADMIAVVQQGKVIEKGTHDEMIKDPEGTYSQLVRLQEGSKKEEAIDK 606
Query: 1905 PPLAAR-----QLSQELSPLHSYAIQRSTSNDAGVHDDDMERILDELSK------EGAKK 1759
P + S + +HS + + + D E + +S + K+
Sbjct: 607 EPEKCEMSLEIESSDSQNGIHSGTLTSPSGLPGVISLDQTEEFHENISSTKTQTVKKGKE 666
Query: 1758 SNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYYSHLWA 1579
+LR + +P+ L + + I G+ +P+ L+ RT F + S WA
Sbjct: 667 VSLRRLAHLNKPEISVLLLGSLAAVIHGIVFPVQGLLLSRTIRIFFEPSNKLKNDSLFWA 726
Query: 1578 LSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSN 1399
L F+ L + + + Q Y F +L R+R SF +L +++DD +S+ +
Sbjct: 727 LIFVALGLTDLIVIPLQNYLFAIAGAKLIKRIRSLSFDRVLHQDISWFDDTKNSSGVIGA 786
Query: 1398 RLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXX 1219
RL+TD+S VK+ V D LG ++ + I A A W + L L+ P
Sbjct: 787 RLSTDASTVKSIVGDVLGLIMQNMATIIGAFIIAFTANWLLALMALLVAPVMFFQGYYQI 846
Query: 1218 XXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAI 1039
+ +E +++ A +A+ ++RTV + EDK+M L E + + FK +
Sbjct: 847 KFITGFGAKARGKYEEASQVASDAVSSIRTVASFCAEDKVMDLYQEKCDEPKQQGFKLGL 906
Query: 1038 IQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLP 859
+ G G S + SV F G++L + + + V L++TA + P
Sbjct: 907 VSGLCYGGSYLALYVIESVCFLGGSWLIQNRRATFGEFFQVFFALTLTAVGVTQTSTMAP 966
Query: 858 DYKKAVHAAGLIFHLFTYPATMPFSSSDGK-KNIEKGEIIGENVQFHYDQRPDRMILNGV 682
D KA +A IF + + SS G I G+I ++V F Y RPD I + +
Sbjct: 967 DINKAKDSAASIFDILDSKPKIDSSSEKGTILPIVHGDIELQHVSFRYPMRPDIQIFSDL 1026
Query: 681 NLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALV 502
L + G+T+ALVG SG GKST+ISLLERFY G++ +D ++ + L+ LR + LV
Sbjct: 1027 CLTISSGQTVALVGESGSGKSTVISLLERFYDPDSGKILLDQVEIQSLKLSWLREQMGLV 1086
Query: 501 SQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLS 322
SQEP LFN +I N+ YG + E+ A + AN NF+ PQG +T VGERG QLS
Sbjct: 1087 SQEPVLFNETIGSNIAYGKIGGATEEEIITAAKAANVHNFISSLPQGYETSVGERGVQLS 1146
Query: 321 GGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTV 142
GGQKQRIAIARAIL++PK+LLLDEATSALD++SE+VVQ+ALD +TVVVAH L+T+
Sbjct: 1147 GGQKQRIAIARAILKDPKILLLDEATSALDAESERVVQDALDQVMVNRTTVVVAHLLTTI 1206
Query: 141 VNADSIAVLKNGKVAEQGTHEELL 70
+AD IAV+KNG +AE G HE L+
Sbjct: 1207 KDADMIAVVKNGVIAESGRHETLM 1230
Score = 294 bits (752), Expect = 1e-77
Identities = 195/570 (34%), Positives = 300/570 (52%), Gaps = 4/570 (0%)
Frame = -1
Query: 1728 RPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYYS-HLWALSFMFLAVF 1552
R D + I + G++ P ++ L+ + F D ++ A+ F++LA +
Sbjct: 29 RYDIVLMVIGTLSAMANGLTQPFMSILMGQLINVFGFSDHDHVFKEVSKVAVKFLYLAAY 88
Query: 1551 RPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNV 1372
+ + Q + E+ STR+R +L F+D ++ + R++ D+ +
Sbjct: 89 AGVVSFLQVSCWMVTGERQSTRIRRLYLKTILRQDIGFFDTETNTG-EVIGRMSGDTILI 147
Query: 1371 KAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQE 1192
+ ++ +++G V + T A + K+TL +L P Q
Sbjct: 148 QDSMGEKVGKFTQLVSSFVGGFTVAFIVGMKLTLALLPCVPLIVGTGGAMTYIMSKKAQR 207
Query: 1191 DTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLS 1012
+A+ + +A+ ++RTV A E + M + L+ +KS K+ + G G+
Sbjct: 208 VQLAYTEAGNVVQQAVGSIRTVVAFTGEKQSMGKYEKKLEIAYKSMVKQGLYSGLGIGIM 267
Query: 1011 LSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMA-GSAAAYLPDYKKAVHA 835
+ Y + +G + K V+ ++ +T MA G L + A
Sbjct: 268 MVVVYCTYGFAIWYGARQIIEKGYTGGQVMNVITSI-LTGGMALGQTLPSLNSFAAGTAA 326
Query: 834 AGLIFHLFTYPATMPFSSSDGKKNIE-KGEIIGENVQFHYDQRPDRMILNGVNLKVDPGK 658
A +F + G+ E KG+I +V F Y RPD I G +L V G
Sbjct: 327 AYKMFETIKRKPKIDAYDMSGEVLEEIKGDIELRDVYFRYPARPDVQIFVGFSLTVPNGM 386
Query: 657 TLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFN 478
T+ALVG SG GKST+ISL+ERFY GEV ID +++ + +RS + LVSQEP LF
Sbjct: 387 TVALVGQSGSGKSTVISLIERFYDPESGEVLIDGIDLKKFQVKWIRSKIGLVSQEPILFA 446
Query: 477 CSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIA 298
+IREN++YG + Q E+ AL+ ANA NF+ + PQGL+T+VGE G QLSGGQKQRIA
Sbjct: 447 TTIRENIVYGKKDASDQ-EIRTALKLANASNFIDKLPQGLETMVGEHGTQLSGGQKQRIA 505
Query: 297 IARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAV 118
IARAIL+NPK+LLLDEATSALD++SE++VQ+AL +TVVVAHRL+T+ AD IAV
Sbjct: 506 IARAILKNPKILLLDEATSALDAESERIVQDALVKLMLSRTTVVVAHRLTTIRTADMIAV 565
Query: 117 LKNGKVAEQGTHEELLR-KRSIYWRLVQKQ 31
++ GKV E+GTH+E+++ Y +LV+ Q
Sbjct: 566 VQQGKVIEKGTHDEMIKDPEGTYSQLVRLQ 595
Score = 270 bits (691), Expect = 1e-70
Identities = 179/577 (31%), Positives = 282/577 (48%), Gaps = 41/577 (7%)
Frame = -1
Query: 3555 LFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQ 3376
+ LLG L +++ G P ++ +N + N ++ A +
Sbjct: 682 VLLLGSLAAVIHGIVFPVQGLLLSRTIRIFFEPSNKLKNDSLFWALI------------- 728
Query: 3375 VVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSV--STGHL 3202
F G I LQ+ + G R+R R+L +D +FD S+G +
Sbjct: 729 ----FVALGLTDLIVIPLQNYLFAIAGAKLIKRIRSLSFDRVLHQDISWFDDTKNSSGVI 784
Query: 3201 STVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFI 3022
L+ + + + + + LI+ + +AF +W LA + + + F G+
Sbjct: 785 GARLSTDASTVKSIVGDVLGLIMQNMATIIGAFIIAFTANWLLALMALLVAPVMFFQGYY 844
Query: 3021 NSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRR 2842
+ K Y A +A + + +TV S + ++ Y E+ ++ G +
Sbjct: 845 QIKFITGFGAKARGKYEEASQVASDAVSSIRTVASFCAEDKVMDLYQEKCDEPKQQGFKL 904
Query: 2841 ALMYSISRGVTYFFCNSLNTVVLYVGATMIYS--------------------GTLETAVV 2722
L+ + G +Y + +V G+ +I + G +T+ +
Sbjct: 905 GLVSGLCYGGSYLALYVIESVCFLGGSWLIQNRRATFGEFFQVFFALTLTAVGVTQTSTM 964
Query: 2721 VRDDNVIEK------DETDYDVEVE-----------VNGNISFKNVKFSYPTRPDAQVLK 2593
D N + D D +++ V+G+I ++V F YP RPD Q+
Sbjct: 965 APDINKAKDSAASIFDILDSKPKIDSSSEKGTILPIVHGDIELQHVSFRYPMRPDIQIFS 1024
Query: 2592 GISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIG 2413
+ + +G+ +ALVG SGSGKSTV+ LL +Y+ DSG I +D +++ + + LR +G
Sbjct: 1025 DLCLTISSGQTVALVGESGSGKSTVISLLERFYDPDSGKILLDQVEIQSLKLSWLREQMG 1084
Query: 2412 VVSQEPVLFNTTIEENIRFGN-PNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQ 2236
+VSQEPVLFN TI NI +G + EI A + AN ++F+ S P+G +T VGERG Q
Sbjct: 1085 LVSQEPVLFNETIGSNIAYGKIGGATEEEIITAAKAANVHNFISSLPQGYETSVGERGVQ 1144
Query: 2235 LSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLS 2056
LSGGQKQRIAIAR ++++PKILLLDEATSALD ESE+VVQ AL+ RTT+VVAH L+
Sbjct: 1145 LSGGQKQRIAIARAILKDPKILLLDEATSALDAESERVVQDALDQVMVNRTTVVVAHLLT 1204
Query: 2055 TIRNASKIIVMQKGEIVEVGNHDELI-AKRGVYNDLV 1948
TI++A I V++ G I E G H+ L+ G Y LV
Sbjct: 1205 TIKDADMIAVVKNGVIAESGRHETLMEISGGAYASLV 1241
>gi|266518|sp|Q00449|MDR4_DROME Multidrug resistance protein homolog
49 (P-glycoprotein 49)
gi|103251|pir||A41249 multidrug resistance protein homolog Mdr49 -
fruit fly (Drosophila melanogaster)
gi|157871|gb|AAA28679.1| P glycoprotein
gi|16198339|gb|AAL14020.1| SD10012p [Drosophila melanogaster]
Length = 1302
Score = 650 bits (1676), Expect = 0.0
Identities = 421/1275 (33%), Positives = 654/1275 (51%), Gaps = 87/1275 (6%)
Frame = -1
Query: 3588 VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPA---- 3421
+F+ S+ E+FL ++ +L + P+ +GE + +LV T + T PA
Sbjct: 34 LFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGEFTSLLVDRTVGVG--TSSPAFALP 91
Query: 3420 ------DLEKAYEEYERGMNQVVFH--------FFLCGCAYFIFASLQHAIMKYVGDNTT 3283
L A +E NQ + + A F+ +L + + N
Sbjct: 92 MFGGGQQLTNASKEEN---NQAIIDDATAFGIGSLVGSVAMFLLITLAIDLANRIALNQI 148
Query: 3282 YRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGT 3103
R+RK ++ +L++D ++D+ S + ++ + ++L++ +E EKI +++ + F +G
Sbjct: 149 DRIRKLFLEAMLRQDIAWYDTSSGSNFASKMTEDLDKLKEGIGEKIVIVVFLIMTFVIGI 208
Query: 3102 ALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTV 2923
AF W+L + I + + + K+ Y++A ++ + +TV
Sbjct: 209 VSAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEEVFSGIRTV 268
Query: 2922 CSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIY-- 2749
+ +GQ+ E ER+ + L E G ++ L + +++ + ++ G T+I
Sbjct: 269 FAFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGVTLILDE 328
Query: 2748 ------------------------------------------SGTLETAVVVRDDNVIEK 2695
+G ++ R V
Sbjct: 329 RDLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPM 388
Query: 2694 DETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVV 2515
DE E G+I F+ ++F YP RPD ++LKG++ DV G+ +A VGASG GKST++
Sbjct: 389 DEKGNRPE-NTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLI 447
Query: 2514 QLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSL 2335
QL+ +Y+ ++G++ +DG DL +N+ LR IGVV QEPVLF TTI ENIR+G P+ +
Sbjct: 448 QLMQRFYDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQ 507
Query: 2334 PEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEA 2155
+I A R AN +DF+ PKG T VGE+G Q+SGGQKQRIAIAR LVR P++LLLDEA
Sbjct: 508 ADIEKAARAANCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEA 567
Query: 2154 TSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIA 1975
TSALD SE+ VQ ALE ASQG TT+VVAHRLSTI NA KI+ ++ G + E G H+EL+
Sbjct: 568 TSALDPTSEKRVQSALELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELME 627
Query: 1974 KRGVYNDLVQ-AQLLESHDDHEELPPLAARQLSQELSPLHS------------YAIQRS- 1837
+RG+Y +LV Q E+ + E Q SQ LS + +Q S
Sbjct: 628 RRGLYCELVSITQRKEATEADEGAVAGRPLQKSQNLSDEETDDDEEDEEEDEEPELQTSG 687
Query: 1836 TSNDAGVHDDD-----MERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGV 1672
+S D+G +R + KE K + +++K P++ F+ + S + G
Sbjct: 688 SSRDSGFRASTRRKRRSQRRKKKKDKEVVSKVSFTQLMKLNSPEWRFIVVGGIASVMHGA 747
Query: 1671 SYPILAQLIVRTYEGFAMIGEDMLYYSHLWALSFMFLAV--FRPLTLYCQYYYFGKVSEQ 1498
++P+ L + G G+D + + + +S +F+ + L Q Y F +
Sbjct: 748 TFPLWG-LFFGDFFGILSDGDDDVVRAEVLKISMIFVGIGLMAGLGNMLQTYMFTTAGVK 806
Query: 1497 LSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAI 1318
++TRLR ++F ++ A++DD +S L +RL +D SNV+ A R+G ++ V +
Sbjct: 807 MTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASDCSNVQGATGARVGTMLQAVATL 866
Query: 1317 SIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALEN 1138
+ + ++ W+ TL L+ P + Q+ + E +++ A+EA+ N
Sbjct: 867 VVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQKAKASIEEASQVAVEAITN 926
Query: 1137 VRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYL 958
+RTV L LE +++ + + ++ + ++ +G L + Y +S +G L
Sbjct: 927 IRTVNGLCLERQVLDQYVQQIDRVDVACRRKVRFRGLVFALGQAAPFLAYGISMYYGGIL 986
Query: 957 ALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSS 778
+ + D V L + M G A AY P+ A+ +AG + LF +T P
Sbjct: 987 VAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNVNDAILSAGRLMDLFKRTSTQPNPPQ 1046
Query: 777 DGKKNIEK--GEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISL 604
+EK G+I+ ENV F Y R IL G+NL + T+ALVGPSG GKST + L
Sbjct: 1047 SPYNTVEKSEGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQL 1106
Query: 603 LERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYG--LTRSVP 430
L R+Y V G V + + L+ LRS L LVSQEP LF+ +I EN+ YG V
Sbjct: 1107 LLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVS 1166
Query: 429 QLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDE 250
E+ +A + +N NF+ PQG DT +G + +QLSGGQKQRIAIARA++RNPK+L+LDE
Sbjct: 1167 MQEIIEAAKKSNIHNFISALPQGYDTRLG-KTSQLSGGQKQRIAIARALVRNPKILILDE 1225
Query: 249 ATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELL 70
ATSALD +SEKVVQ ALD A + + +AHRL+TV NAD I VLK G V E GTH+EL+
Sbjct: 1226 ATSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELM 1285
Query: 69 RKRSIYWRLVQKQGI 25
IY L Q +
Sbjct: 1286 ALNKIYANLYLMQQV 1300
>gi|24653245|ref|NP_523724.2| CG3879-PA [Drosophila melanogaster]
gi|21627300|gb|AAF58437.2| CG3879-PA [Drosophila melanogaster]
Length = 1302
Score = 649 bits (1675), Expect = 0.0
Identities = 421/1275 (33%), Positives = 654/1275 (51%), Gaps = 87/1275 (6%)
Frame = -1
Query: 3588 VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPA---- 3421
+F+ S+ E+FL ++ +L + P+ +GE + +LV T + T PA
Sbjct: 34 LFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGEFTSLLVDRTVGVG--TSSPAFALP 91
Query: 3420 ------DLEKAYEEYERGMNQVVFH--------FFLCGCAYFIFASLQHAIMKYVGDNTT 3283
L A +E NQ + + A F+ +L + + N
Sbjct: 92 MFGGGQQLTNASKEEN---NQAIIDDATAFGIGSLVGSVAMFLLITLAIDLANRIALNQI 148
Query: 3282 YRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGT 3103
R+RK ++ +L++D ++D+ S + ++ + ++L++ +E EKI +++ + F +G
Sbjct: 149 DRIRKLFLEAMLRQDIAWYDTSSGSNFASKMTEDLDKLKEGIGEKIVIVVFLIMTFVIGI 208
Query: 3102 ALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTV 2923
AF W+L + I + + + K+ Y++A ++ + +TV
Sbjct: 209 VSAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEEVFSGIRTV 268
Query: 2922 CSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIY-- 2749
+ +GQ+ E ER+ + L E G ++ L + +++ + ++ G T+I
Sbjct: 269 FAFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGVTLILDE 328
Query: 2748 ------------------------------------------SGTLETAVVVRDDNVIEK 2695
+G ++ R V
Sbjct: 329 RDLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPM 388
Query: 2694 DETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVV 2515
DE E G+I F+ ++F YP RPD ++LKG++ DV G+ +A VGASG GKST++
Sbjct: 389 DEKGNRPE-NTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLI 447
Query: 2514 QLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSL 2335
QL+ +Y+ ++G++ +DG DL +N+ LR IGVV QEPVLF TTI ENIR+G P+ +
Sbjct: 448 QLMQRFYDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQ 507
Query: 2334 PEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEA 2155
+I A R AN +DF+ PKG T VGE+G Q+SGGQKQRIAIAR LVR P++LLLDEA
Sbjct: 508 ADIEKAARAANCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEA 567
Query: 2154 TSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIA 1975
TSALD SE+ VQ ALE ASQG TT+VVAHRLSTI NA KI+ ++ G + E G H+EL+
Sbjct: 568 TSALDPTSEKRVQSALELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELME 627
Query: 1974 KRGVYNDLVQ-AQLLESHDDHEELPPLAARQLSQELSPLHS------------YAIQRS- 1837
+RG+Y +LV Q E+ + E Q SQ LS + +Q S
Sbjct: 628 RRGLYCELVSITQRKEATEADEGAVAGRPLQKSQNLSDEETDDDEEDEEEDEEPELQTSG 687
Query: 1836 TSNDAGVHDDD-----MERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGV 1672
+S D+G +R + KE K + +++K P++ F+ + S + G
Sbjct: 688 SSRDSGFRASTRRKRRSQRRKKKKDKEVVSKVSFTQLMKLNSPEWRFIVVGGIASVMHGA 747
Query: 1671 SYPILAQLIVRTYEGFAMIGEDMLYYSHLWALSFMFLAV--FRPLTLYCQYYYFGKVSEQ 1498
++P+ L + G G+D + + + +S +F+ + L Q Y F +
Sbjct: 748 TFPLWG-LFFGDFFGILSDGDDDVVRAEVLKISMIFVGIGLMAGLGNMLQTYMFTTAGVK 806
Query: 1497 LSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAI 1318
++TRLR ++F ++ A++DD +S L +RL +D SNV+ A R+G ++ V +
Sbjct: 807 MTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASDCSNVQGATGARVGTMLQAVATL 866
Query: 1317 SIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALEN 1138
+ + ++ W+ TL L+ P + Q+ + E +++ A+EA+ N
Sbjct: 867 VVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQKAKASIEEASQVAVEAITN 926
Query: 1137 VRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYL 958
+RTV L LE +++ + + ++ + ++ +G L + Y +S +G L
Sbjct: 927 IRTVNGLCLERQVLDQYVQQIDRVDIACRRKVRFRGLVFALGQAAPFLAYGISMYYGGIL 986
Query: 957 ALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSS 778
+ + D V L + M G A AY P+ A+ +AG + LF +T P
Sbjct: 987 VAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNVNDAILSAGRLMDLFKRTSTQPNPPQ 1046
Query: 777 DGKKNIEK--GEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISL 604
+EK G+I+ ENV F Y R IL G+NL + T+ALVGPSG GKST + L
Sbjct: 1047 SPYNTVEKSEGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQL 1106
Query: 603 LERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYG--LTRSVP 430
L R+Y V G V + + L+ LRS L LVSQEP LF+ +I EN+ YG V
Sbjct: 1107 LLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVS 1166
Query: 429 QLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDE 250
E+ +A + +N NF+ PQG DT +G + +QLSGGQKQRIAIARA++RNPK+L+LDE
Sbjct: 1167 MQEIIEAAKKSNIHNFISALPQGYDTRLG-KTSQLSGGQKQRIAIARALVRNPKILILDE 1225
Query: 249 ATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELL 70
ATSALD +SEKVVQ ALD A + + +AHRL+TV NAD I VLK G V E GTH+EL+
Sbjct: 1226 ATSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELM 1285
Query: 69 RKRSIYWRLVQKQGI 25
IY L Q +
Sbjct: 1286 ALNKIYANLYLMQQV 1300
>gi|50546639|ref|XP_500789.1| hypothetical protein [Yarrowia
lipolytica]
gi|49646655|emb|CAG83040.1| unnamed protein product [Yarrowia
lipolytica CLIB99]
Length = 1304
Score = 649 bits (1674), Expect = 0.0
Identities = 425/1264 (33%), Positives = 656/1264 (51%), Gaps = 63/1264 (4%)
Frame = -1
Query: 3624 KKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAI 3445
+ P + +F+ +F+ + F+ FL ++G++ + G C P + FG ++TN
Sbjct: 65 RTPDTVVTFM-TLFRYADKFDFFLIMVGLVMAAAAGVCLPIFTIIFG-------SMTNEF 116
Query: 3444 NNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQ 3265
N + A + E ++ +N +F A F +++ I G+ T R+R
Sbjct: 117 TNFFVYGA----SKEHFQSRINHFALYFVYLAVATFGTTAIKTYITVERGERLTARIRAN 172
Query: 3264 YISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYT 3085
Y+ +L+++ YFD + G ++ + + +E +EK+ LI++ + F + F
Sbjct: 173 YLKAILRQNIGYFDKLGAGEVTNRITSDTNLIQEGISEKLGLIVSAIASFITALVIGFIK 232
Query: 3084 DWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQ 2905
+L + +A S I S ++K T + SIA + + + + + Q
Sbjct: 233 QAKLTGIMLSTVFALALSMGICSTFLVKYTKLALEDDSACSSIAEEAFSSIRNIVAFGSQ 292
Query: 2904 KTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYSGTLETAV 2725
+E+Y L + +R+ + ++ G + + L+ G+ ++ G +
Sbjct: 293 SRMVEKYNVPLASSLHNYLRKNISLAVMVGCLWSLIYIKYALALWEGSRLVAWGETQVGN 352
Query: 2724 VVRD-----------------------------------DNVIEKDETDYDVEV-EVNGN 2653
V D V E D + ++ ++ G+
Sbjct: 353 VTTVLMALMIGAFELGGVAPNLESVGVAIASGKKIFGTIDRVPEIDTQEEGEKIPDIKGH 412
Query: 2652 ISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNI 2473
I F NV F YP+RP Q+L+ + +V G+ +ALVGASGSGKST++ LL +Y SG I
Sbjct: 413 IVFDNVDFRYPSRPKVQILEDFNLEVLPGQTVALVGASGSGKSTLIGLLERFYQPLSGLI 472
Query: 2472 FIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFG---------NPNVSLPEIYG 2320
IDG +L D+++K LR+ I +VSQEP LFN TI ENI FG + + +
Sbjct: 473 TIDGYNLLDLDVKWLRQHISLVSQEPTLFNCTIYENITFGLIGTQWEHADDEKKMELVEH 532
Query: 2319 ALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALD 2140
A R+ANA+DF+ GI T VGE G LSGGQKQRIAIAR ++ NP ILLLDEATSALD
Sbjct: 533 ACRQANAWDFIQLLTDGINTNVGESGMLLSGGQKQRIAIARAIISNPPILLLDEATSALD 592
Query: 2139 NESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVY 1960
+SE +VQ+AL+ AS+ RTTIV+AHRLSTI+NASKI+VM KGEI+E G H EL+AK+G+Y
Sbjct: 593 TKSEGIVQEALDKASENRTTIVIAHRLSTIKNASKIVVMSKGEIIEQGTHAELLAKQGMY 652
Query: 1959 NDLVQAQLL-------ESHDDHEELPPLAARQLSQELSPLHSYAIQRSTSNDAGVHDDDM 1801
LV AQ L +S D E+ P L I +ST+N +
Sbjct: 653 YGLVDAQKLTEARPGQKSSSDGEDAPLLIQED---------DMKIGKSTTNKSLSSQILA 703
Query: 1800 ERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFA 1621
+ + K + ++ + K R + FL++ F + I G YP LA L + F
Sbjct: 704 NKEKPDRDKHLSIAGMVKLLAKYNRNERPFLYVGSFAALINGAGYPALALLFASAMQAF- 762
Query: 1620 MIGEDMLYY--SHLWALS-FMFL-AVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLS 1453
M+ DM ++ S + S F+F+ + + + Q Y G SE L +R FSH+L
Sbjct: 763 MVSPDMYHWMRSEMNKYSGFLFMVGMIELMAYFVQIYCLGWCSEHLVRNIRHSVFSHLLR 822
Query: 1452 LPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMT 1273
+ AF+D+ +++ L++ L+ D+ V+ G ++ ++ I I + A Y W++
Sbjct: 823 MDVAFHDEDDNTTGSLTSTLSKDAQYVQGLGGATFGQILSSLCTIVIGVIIAICYTWRLG 882
Query: 1272 LEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMS 1093
L P +E S A EA ++RTV L ED +
Sbjct: 883 LVCTACVPLIIAAGFFRFWILTHLNLRGKKVYEQSASYACEATTSIRTVVTLTREDYV-- 940
Query: 1092 LISEHLQKIHKSYFKRA---IIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTY 922
+++L K+ A I S S L + ++ F +G+ L + +
Sbjct: 941 -YNDYLHKVESQVADSARANIYSATLFAASQSLNLLISALGFWYGSTLMKDGIIDTNKFF 999
Query: 921 LVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDG---KKNIEKG 751
+ +++ AGS ++ PD KA A I ++ + S++G + +G
Sbjct: 1000 VAFVSVVFGCQSAGSIFSFTPDMGKAKTATQNIANMLAVLPELDVDSTEGIILDHDNVRG 1059
Query: 750 EIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGE 571
+I E+V+F Y RP IL G+NL + G+ +ALVG SGCGKST I+L+ERFY + G
Sbjct: 1060 DISFEDVRFRYPTRPQVPILRGLNLNIKKGQYVALVGSSGCGKSTTIALIERFYDVLSGA 1119
Query: 570 VKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTR-SVPQLELEKALQTAN 394
VK+D ++ DIN+N RS ++LV QEP LF+ ++REN+L G R V + E+ +A + AN
Sbjct: 1120 VKLDGVDIRDININSYRSCISLVQQEPVLFSGTVRENILLGSLRDDVTEEEMIEAAEMAN 1179
Query: 393 AFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKV 214
+FV P G DT G +G+ LSGGQKQR+AIARA++RNPK+LLLDEATSALDS+SEK+
Sbjct: 1180 IHSFVMSLPDGYDTYCGSKGSLLSGGQKQRVAIARALIRNPKILLLDEATSALDSESEKI 1239
Query: 213 VQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQK 34
VQ ALD A++ +T+ VAHRLST+ NAD I V + G+V E GTH+ELL +S Y+ LV+
Sbjct: 1240 VQAALDQAAKGRTTIAVAHRLSTIQNADIIYVFEEGRVLESGTHQELLANKSKYYELVKL 1299
Query: 33 QGIQ 22
Q ++
Sbjct: 1300 QALE 1303
Score = 293 bits (751), Expect = 2e-77
Identities = 196/588 (33%), Positives = 305/588 (51%), Gaps = 17/588 (2%)
Frame = -1
Query: 1722 DYCFLFIAVFGSAIQGVSYPILAQL---IVRTYEGFAMIGEDMLYYS---HLWALSFMFL 1561
D+ + + + +A GV PI + + + F + G ++ + +AL F++L
Sbjct: 84 DFFLIMVGLVMAAAAGVCLPIFTIIFGSMTNEFTNFFVYGASKEHFQSRINHFALYFVYL 143
Query: 1560 AVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDS 1381
AV T + Y + E+L+ R+R +L ++D A ++NR+ +D+
Sbjct: 144 AVATFGTTAIKTYITVERGERLTARIRANYLKAILRQNIGYFD--KLGAGEVTNRITSDT 201
Query: 1380 SNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXA 1201
+ ++ + ++LG ++ + + A+ + K+T +L
Sbjct: 202 NLIQEGISEKLGLIVSAIASFITALVIGFIKQAKLTGIMLS---TVFALALSMGICSTFL 258
Query: 1200 IQEDTIAFENSNRT---AIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQG 1030
++ +A E+ + A EA ++R + A + +++ + L +Y ++ I
Sbjct: 259 VKYTKLALEDDSACSSIAEEAFSSIRNIVAFGSQSRMVEKYNVPLASSLHNYLRKNISLA 318
Query: 1029 AANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYK 850
G S Y+++ G+ L E + VLM L + A G A L
Sbjct: 319 VMVGCLWSLIYIKYALALWEGSRLVAWGETQVGNVTTVLMALMIGAFELGGVAPNLESVG 378
Query: 849 KAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKV 670
A+ + IF + K KG I+ +NV F Y RP IL NL+V
Sbjct: 379 VAIASGKKIFGTIDRVPEIDTQEEGEKIPDIKGHIVFDNVDFRYPSRPKVQILEDFNLEV 438
Query: 669 DPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEP 490
PG+T+ALVG SG GKST+I LLERFY + G + ID N+ D+++ LR +++LVSQEP
Sbjct: 439 LPGQTVALVGASGSGKSTLIGLLERFYQPLSGLITIDGYNLLDLDVKWLRQHISLVSQEP 498
Query: 489 TLFNCSIRENLLYGLTRSV-------PQLEL-EKALQTANAFNFVFQFPQGLDTLVGERG 334
TLFNC+I EN+ +GL + ++EL E A + ANA++F+ G++T VGE G
Sbjct: 499 TLFNCTIYENITFGLIGTQWEHADDEKKMELVEHACRQANAWDFIQLLTDGINTNVGESG 558
Query: 333 AQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHR 154
LSGGQKQRIAIARAI+ NP +LLLDEATSALD+ SE +VQ ALD ASE +T+V+AHR
Sbjct: 559 MLLSGGQKQRIAIARAIISNPPILLLDEATSALDTKSEGIVQEALDKASENRTTIVIAHR 618
Query: 153 LSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQVETP 10
LST+ NA I V+ G++ EQGTH ELL K+ +Y+ LV Q + P
Sbjct: 619 LSTIKNASKIVVMSKGEIIEQGTHAELLAKQGMYYGLVDAQKLTEARP 666
>gi|46390962|dbj|BAD16475.1| putative multidrug resistance
p-glycoprotein [Oryza sativa (japonica cultivar-group)]
Length = 1245
Score = 649 bits (1674), Expect = 0.0
Identities = 426/1247 (34%), Positives = 650/1247 (51%), Gaps = 50/1247 (4%)
Frame = -1
Query: 3621 KPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAIN 3442
K + S VF + + L +LG+L ++ G P V++ IT+ I
Sbjct: 12 KARPVFSSFMTVFMHADAADVALMVLGLLGAMGDGISTP-----------VMLLITSRIF 60
Query: 3441 NKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQY 3262
N AD+ K E+ +N + A ++ A L+ + R+R +Y
Sbjct: 61 NDLGSGADIVK---EFSSKVNVNARNLVFLAAASWVMAFLEGYCWARTAERQASRMRARY 117
Query: 3261 ISRLLKKDAQYFD--SVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFY 3088
+ +L++D +YFD ST + T ++++ ++V +EK+ + F A+ F
Sbjct: 118 LRAVLRQDVEYFDLKKGSTAEVITSVSNDSLVVQDVLSEKVPNFVMNAAMFAGSYAVGFA 177
Query: 3087 TDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNG 2908
WRL + + + GF+ ++ + Y G+IA Q + + +TV S
Sbjct: 178 LLWRLTLVALPSVVLLIIPGFMYGRILVGLARRIREQYTRPGAIAEQAVSSARTVYSFVA 237
Query: 2907 QKTEIERYTEELKAGEKYGIRRALMYSI---SRGVTY----FFCNSLNTVVLY------- 2770
++T + +++ L+ + G+++ L I S G+T+ F + +V+Y
Sbjct: 238 ERTTMAQFSAALEESARLGLKQGLAKGIAVGSNGITFAIWAFNVWYGSRLVMYHGYQGGT 297
Query: 2769 ---------VGATMIYSGTLETAVVVRDDNVIEK------------DETDYDVEV-EVNG 2656
VG + SG + E+ E+D E+ V G
Sbjct: 298 VFAVSAAIVVGGLALGSGLSNVKYFSEASSAAERILEVIRRVPKIDSESDTGEELANVTG 357
Query: 2655 NISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGN 2476
+ F+NV+F YP+RP++ + + V G +ALVG SGSGKSTV+ LL +Y+ +G
Sbjct: 358 EVEFRNVEFCYPSRPESPIFVSFNLRVPAGRTVALVGGSGSGKSTVIALLERFYDPSAGE 417
Query: 2475 IFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAY 2296
+ +DG+D+ + +K LR +G+VSQEP LF T+I ENI FG + E+ A + ANA+
Sbjct: 418 VMVDGVDIRRLRLKWLRAQMGLVSQEPALFATSIRENILFGKEEATAEEVVAAAKAANAH 477
Query: 2295 DFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQ 2116
+F+ P+G T VGERG Q+SGGQKQRIAIAR ++++PKILLLDEATSALD ESE+VVQ
Sbjct: 478 NFISQLPQGYDTQVGERGVQMSGGQKQRIAIARAILKSPKILLLDEATSALDTESERVVQ 537
Query: 2115 KALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAK-RGVYNDLVQAQ 1939
+AL+ AS GRTTIV+AHRLSTIRNA I VMQ GE+ E+G HDELIA G+Y+ LV+ Q
Sbjct: 538 EALDLASMGRTTIVIAHRLSTIRNADIIAVMQSGEVKELGPHDELIANDNGLYSSLVRLQ 597
Query: 1938 LLESHDDHEEL-----PPLAARQLSQELSPLHSYAIQRSTSNDAGVHDDDMERILDELSK 1774
++ +E+ + S +S S A + S++ G DD D K
Sbjct: 598 QTRDSNEIDEIGVTGSTSAVGQSSSHSMSRRFSAASRSSSARSLGDARDD-----DNTEK 652
Query: 1773 EGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQL---IVRTYEGFAMIGEDM 1603
+ R ++ P++ + F + + G P A ++ Y F ++
Sbjct: 653 PKLPVPSFRRLLMLNAPEWKQALMGSFSAVVFGGIQPAYAYAMGSMISVY--FLTDHAEI 710
Query: 1602 LYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPN 1423
+ +AL F+ LAV L Q+Y FG + E L+ R+R + + +L+ ++D
Sbjct: 711 KDKTRTYALIFVGLAVLSFLINIGQHYNFGAMGEYLTKRIREQMLAKILTFEIGWFDRDE 770
Query: 1422 HSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXX 1243
+S+ + ++L D++ V++ V DR+ VI T+ A+ IA T + W++ L ++ P
Sbjct: 771 NSSGAICSQLAKDANVVRSLVGDRMALVIQTISAVLIACTMGLVIAWRLALVMIAVQPLI 830
Query: 1242 XXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIH 1063
++ A S++ A EA+ N+RT+ A + +++I+ L +
Sbjct: 831 IVCFYARRVLLKSMSKKSIHAQAESSKLAAEAVSNLRTITAFSSQERILRLFEQSQDGPR 890
Query: 1062 KSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMA 883
K +++ G G S+S +++ F +G L ++ + + M L T +
Sbjct: 891 KESIRQSWFAGLGLGTSMSLMTCTWALDFWYGGRLMAEHHISAKELFQTFMILVSTGRVI 950
Query: 882 GSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIE-KGEIIGENVQFHYDQRP 706
A + D K A +F + + + G K + KGE+ V F Y RP
Sbjct: 951 ADAGSMTTDLAKGADAVASVFAVLDRETEIDPDNPQGYKPEKLKGEVDIRGVDFAYPSRP 1010
Query: 705 DRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNH 526
D +I G L + PGK+ ALVG SG GKSTII L+ERFY + G VKID +++ NL
Sbjct: 1011 DVIIFKGFTLSIQPGKSTALVGQSGSGKSTIIGLIERFYDPIRGSVKIDGRDIKAYNLRA 1070
Query: 525 LRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLV 346
LR ++ LVSQEPTLF +IREN++YG T + + E+E A ++ANA +F+ G DT
Sbjct: 1071 LRRHIGLVSQEPTLFAGTIRENIVYG-TETASEAEIEDAARSANAHDFISNLKDGYDTWC 1129
Query: 345 GERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVV 166
GERG QLSGGQKQRIAIARAIL+NP +LLLDEATSALDS SEKVVQ ALD ++VV
Sbjct: 1130 GERGVQLSGGQKQRIAIARAILKNPAILLLDEATSALDSQSEKVVQEALDRVMIGRTSVV 1189
Query: 165 VAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRK--RSIYWRLVQKQ 31
VAHRLST+ N D I VL+ G V E+GTH L+ K Y+ LV Q
Sbjct: 1190 VAHRLSTIQNCDLITVLEKGTVVEKGTHASLMAKGLSGTYFSLVNLQ 1236
>gi|15228506|ref|NP_189528.1| multidrug resistance P-glycoprotein,
putative [Arabidopsis thaliana]
gi|9294227|dbj|BAB02129.1| P-glycoprotein; multi-drug resistance
related; ABC transporter-like protein [Arabidopsis
thaliana]
Length = 1252
Score = 649 bits (1674), Expect = 0.0
Identities = 415/1264 (32%), Positives = 645/1264 (50%), Gaps = 52/1264 (4%)
Frame = -1
Query: 3666 SNNFSTPLLPQSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTF 3487
+N +P EKK Q F ++ F + F+ L +G L +++ G P F
Sbjct: 4 TNTTDAKTVPAEAEKKKEQSLPFFKL-FSFADKFDYLLMFVGSLGAIVHGSSMPVFFLLF 62
Query: 3486 GEVSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIM 3307
G++ +N + DL + E R +F G + + A
Sbjct: 63 GQM----------VNGFGKNQMDLHQMVHEVSR----YSLYFVYLGLVVCFSSYAEIACW 108
Query: 3306 KYVGDNTTYRVRKQYISRLLKKDAQYFDS-VSTGHLSTVLNDNLERFREVFNEKIALIIA 3130
Y G+ +RK+Y+ +LK+D +FD+ TG + ++ + ++ +EK+ I
Sbjct: 109 MYSGERQVAALRKKYLEAVLKQDVGFFDTDARTGDIVFSVSTDTLLVQDAISEKVGNFIH 168
Query: 3129 FVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAF 2950
+++ F G + F + W+LA + GIAF+G + + + T K YANAG IA
Sbjct: 169 YLSTFLAGLVVGFVSAWKLALLSVAVIPGIAFAGGLYAYTLTGITSKSRESYANAGVIAE 228
Query: 2949 QTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTY-FFCNSLNTVVL 2773
Q + +TV S G+ + Y++ ++ K G + + + G TY C S V
Sbjct: 229 QAIAQVRTVYSYVGESKALNAYSDAIQYTLKLGYKAGMAKGLGLGCTYGIACMSWALVFW 288
Query: 2772 YVGA-------------TMIYSGTL-----------------------ETAVVVRDDNVI 2701
Y G T I+S + + ++ I
Sbjct: 289 YAGVFIRNGQTDGGKAFTAIFSAIVGGMSLGQSFSNLGAFSKGKAAGYKLMEIINQRPTI 348
Query: 2700 EKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKST 2521
+D D +V+GNI FK+V FSYP+RPD + + + +G+ +A+VG SGSGKST
Sbjct: 349 IQDPLDGKCLDQVHGNIEFKDVTFSYPSRPDVMIFRNFNIFFPSGKTVAVVGGSGSGKST 408
Query: 2520 VVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNV 2341
VV L+ +Y+ +SG I +DG+++ + +K LR IG+V+QEP LF TTI ENI +G P+
Sbjct: 409 VVSLIERFYDPNSGQILLDGVEIKTLQLKFLREQIGLVNQEPALFATTILENILYGKPDA 468
Query: 2340 SLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLD 2161
++ E+ A ANA+ F+ PKG T VGERG QLSGGQKQRIAIAR ++++PKILLLD
Sbjct: 469 TMVEVEAAASAANAHSFITLLPKGYDTQVGERGVQLSGGQKQRIAIARAMLKDPKILLLD 528
Query: 2160 EATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDEL 1981
EATSALD SE +VQ+AL+ GRTT+VVAHRL TIRN I V+Q+G++VE G H+EL
Sbjct: 529 EATSALDASSESIVQEALDRVMVGRTTVVVAHRLCTIRNVDSIAVIQQGQVVETGTHEEL 588
Query: 1980 IAKRGVYNDLVQAQLLESHDDHEE-----------LPPLAARQLSQELSPLHSYAIQRST 1834
IAK G Y L++ Q + D L+ + LS L + + ST
Sbjct: 589 IAKSGAYASLIRFQEMVGTRDFSNPSTRRTRSTRLSHSLSTKSLSLRSGSLRNLSYSYST 648
Query: 1833 SNDAGVHDDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILA 1654
D + +M + K A ++ ++K P++ + + GS + G P A
Sbjct: 649 GADGRI---EMISNAETDRKTRAPENYFYRLLKLNSPEWPYSIMGAVGSILSGFIGPTFA 705
Query: 1653 QLIVRTYEGFAMIGED-MLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRI 1477
++ E F D M + + ++ ++ Q+Y+F + E L+TR+R
Sbjct: 706 IVMSNMIEVFYYTDYDSMERKTKEYVFIYIGAGLYAVGAYLIQHYFFSIMGENLTTRVRR 765
Query: 1476 KSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTA 1297
S +L ++D+ H+++ ++ RL TD+++VK+A+ +R+ ++ + ++ + A
Sbjct: 766 MMLSAILRNEVGWFDEDEHNSSLIAARLATDAADVKSAIAERISVILQNMTSLLTSFIVA 825
Query: 1296 SLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRAL 1117
+ W+++L +L FP + A ++ A E + N+RTV A
Sbjct: 826 FIVEWRVSLLILGTFPLLVLANFAQQLSLKGFAGDTAKAHAKTSMIAGEGVSNIRTVAAF 885
Query: 1116 NLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVA 937
N + KI+SL L+ K R+ G GLS ++ +G +L +
Sbjct: 886 NAQSKILSLFCHELRVPQKRSLYRSQTSGFLFGLSQLALYGSEALILWYGAHLVSKGVST 945
Query: 936 PMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKK-NI 760
V + L +TAN + P+ + A G +F + + +D
Sbjct: 946 FSKVIKVFVVLVITANSVAETVSLAPEIIRGGEAVGSVFSVLDRQTRIDPDDADADPVET 1005
Query: 759 EKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAV 580
+G+I +V F Y RPD M+ NL++ G + ALVG SG GKS++I+++ERFY +
Sbjct: 1006 IRGDIEFRHVDFAYPSRPDVMVFRDFNLRIRAGHSQALVGASGSGKSSVIAMIERFYDPL 1065
Query: 579 DGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQT 400
G+V ID +++ +NL LR + LV QEP LF +I +N+ YG + E+ A +
Sbjct: 1066 AGKVMIDGKDIRRLNLKSLRLKIGLVQQEPALFAATIFDNIAYG-KDGATESEVIDAARA 1124
Query: 399 ANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSE 220
ANA F+ P+G T VGERG QLSGGQKQRIAIARA+L+NP VLLLDEATSALD++SE
Sbjct: 1125 ANAHGFISGLPEGYKTPVGERGVQLSGGQKQRIAIARAVLKNPTVLLLDEATSALDAESE 1184
Query: 219 KVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELL-RKRSIYWRL 43
V+Q AL+ +TVVVAHRLST+ D I V+++G++ EQG+H EL+ R Y RL
Sbjct: 1185 CVLQEALERLMRGRTTVVVAHRLSTIRGVDCIGVIQDGRIVEQGSHSELVSRPEGAYSRL 1244
Query: 42 VQKQ 31
+Q Q
Sbjct: 1245 LQLQ 1248
>gi|24324262|gb|AAN28720.2| MDR-like p-glycoprotein [Arabidopsis
thaliana]
Length = 1252
Score = 649 bits (1674), Expect = 0.0
Identities = 415/1264 (32%), Positives = 645/1264 (50%), Gaps = 52/1264 (4%)
Frame = -1
Query: 3666 SNNFSTPLLPQSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTF 3487
+N +P EKK Q F ++ F + F+ L +G L +++ G P F
Sbjct: 4 TNTTDAKTVPAEAEKKKEQSLPFFKL-FSFADKFDYLLMFVGSLGAIVHGSSMPVFFLLF 62
Query: 3486 GEVSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIM 3307
G++ +N + DL + E R +F G + + A
Sbjct: 63 GQM----------VNGFGKNQMDLHQMVHEVSR----YSLYFVYLGLVVCFSSYAEIACW 108
Query: 3306 KYVGDNTTYRVRKQYISRLLKKDAQYFDS-VSTGHLSTVLNDNLERFREVFNEKIALIIA 3130
Y G+ +RK+Y+ +LK+D +FD+ TG + ++ + ++ +EK+ I
Sbjct: 109 MYSGERQVAALRKKYLEAVLKQDVGFFDTDARTGDIVFSVSTDTLLVQDAISEKVGNFIH 168
Query: 3129 FVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAF 2950
+++ F G + F + W+LA + GIAF+G + + + T K YANAG IA
Sbjct: 169 YLSTFLAGLVVGFVSAWKLALLSVAVIPGIAFAGGLYAYTLTGITSKSRESYANAGVIAE 228
Query: 2949 QTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTY-FFCNSLNTVVL 2773
Q + +TV S G+ + Y++ ++ K G + + + G TY C S V
Sbjct: 229 QAIAQVRTVYSYVGESKALNAYSDAIQYTLKLGYKAGMAKGLGLGCTYGIACMSWALVFW 288
Query: 2772 YVGA-------------TMIYSGTL-----------------------ETAVVVRDDNVI 2701
Y G T I+S + + ++ I
Sbjct: 289 YAGVFIRNGQTDGGKAFTAIFSAIVGGMSLGQSFSNLGAFSKGKAAGYKLMEIINQRPTI 348
Query: 2700 EKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKST 2521
+D D +V+GNI FK+V FSYP+RPD + + + +G+ +A+VG SGSGKST
Sbjct: 349 IQDPLDGKCLDQVHGNIEFKDVTFSYPSRPDVMIFRNFNIFFPSGKTVAVVGGSGSGKST 408
Query: 2520 VVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNV 2341
VV L+ +Y+ +SG I +DG+++ + +K LR IG+V+QEP LF TTI ENI +G P+
Sbjct: 409 VVSLIERFYDPNSGQILLDGVEIKTLQLKFLREQIGLVNQEPALFATTILENILYGKPDA 468
Query: 2340 SLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLD 2161
++ E+ A ANA+ F+ PKG T VGERG QLSGGQKQRIAIAR ++++PKILLLD
Sbjct: 469 TMVEVEAAASAANAHSFITLLPKGYDTQVGERGVQLSGGQKQRIAIARAMLKDPKILLLD 528
Query: 2160 EATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDEL 1981
EATSALD SE +VQ+AL+ GRTT+VVAHRL TIRN I V+Q+G++VE G H+EL
Sbjct: 529 EATSALDASSESIVQEALDRVMVGRTTVVVAHRLCTIRNVDSIAVIQQGQVVETGTHEEL 588
Query: 1980 IAKRGVYNDLVQAQLLESHDDHEE-----------LPPLAARQLSQELSPLHSYAIQRST 1834
IAK G Y L++ Q + D L+ + LS L + + ST
Sbjct: 589 IAKSGAYASLIRFQEMVGTRDFSNPSTRRTRSTRLSHSLSTKSLSLRSGSLRNLSYSYST 648
Query: 1833 SNDAGVHDDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILA 1654
D + +M + K A ++ ++K P++ + + GS + G P A
Sbjct: 649 GADGRI---EMISNAETDRKTRAPENYFYRLLKLNSPEWPYSIMGAVGSILSGFIGPTFA 705
Query: 1653 QLIVRTYEGFAMIGED-MLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRI 1477
++ E F D M + + ++ ++ Q+Y+F + E L+TR+R
Sbjct: 706 IVMSNMIEVFYYTDYDSMERKTKEYVFIYIGAGLYAVGAYLIQHYFFSIMGENLTTRVRR 765
Query: 1476 KSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTA 1297
S +L ++D+ H+++ ++ RL TD+++VK+A+ +R+ ++ + ++ + A
Sbjct: 766 MMLSAILRNEVGWFDEDEHNSSLIAARLATDAADVKSAIAERISVILQNMTSLLTSFIVA 825
Query: 1296 SLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRAL 1117
+ W+++L +L FP + A ++ A E + N+RTV A
Sbjct: 826 FIVEWRVSLLILGTFPLLVLANFAQQLSLKGFAGDTAKAHAKTSMIAGEGVSNIRTVAAF 885
Query: 1116 NLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVA 937
N + KI+SL L+ K R+ G GLS ++ +G +L +
Sbjct: 886 NAQSKILSLFCHELRVPQKRSLYRSQTSGFLFGLSQLALYGSEALILWYGAHLVSKGVST 945
Query: 936 PMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKK-NI 760
V + L +TAN + P+ + A G +F + + +D
Sbjct: 946 FSKVIKVFVVLVITANSVAETVSLAPEIIRGGEAVGSVFSVLDRQTRIDPDDADADPVET 1005
Query: 759 EKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAV 580
+G+I +V F Y RPD M+ NL++ G + ALVG SG GKS++I+++ERFY +
Sbjct: 1006 IRGDIEFRHVDFAYPSRPDVMVFRDFNLRIRAGHSQALVGASGSGKSSVIAMIERFYDLL 1065
Query: 579 DGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQT 400
G+V ID +++ +NL LR + LV QEP LF +I +N+ YG + E+ A +
Sbjct: 1066 AGKVMIDGKDIRRLNLKSLRLKIGLVQQEPALFAATIFDNIAYG-KDGATESEVIDAARA 1124
Query: 399 ANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSE 220
ANA F+ P+G T VGERG QLSGGQKQRIAIARA+L+NP VLLLDEATSALD++SE
Sbjct: 1125 ANAHGFISGLPEGYKTPVGERGVQLSGGQKQRIAIARAVLKNPTVLLLDEATSALDAESE 1184
Query: 219 KVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELL-RKRSIYWRL 43
V+Q AL+ +TVVVAHRLST+ D I V+++G++ EQG+H EL+ R Y RL
Sbjct: 1185 CVLQEALERLMRGRTTVVVAHRLSTIRGVDCIGVIQDGRIVEQGSHSELVSRPEGAYSRL 1244
Query: 42 VQKQ 31
+Q Q
Sbjct: 1245 LQLQ 1248
>gi|15217786|ref|NP_171754.1| multidrug resistance P-glycoprotein,
putative [Arabidopsis thaliana]
Length = 1273
Score = 648 bits (1672), Expect = 0.0
Identities = 419/1252 (33%), Positives = 647/1252 (51%), Gaps = 68/1252 (5%)
Frame = -1
Query: 3588 VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEK 3409
+F + F+ FL + G L ++ G C P M+ FG++ + + NNK I
Sbjct: 33 LFAFADSFDVFLMICGSLGAIGNGVCLPLMTLLFGDL---IDSFGKNQNNKDIVDV---- 85
Query: 3408 AYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQY 3229
+++V F G A LQ A G+ ++R Y+ +L++D +
Sbjct: 86 --------VSKVCLKFVYLGLGRLGAAFLQVACWMITGERQAAKIRSNYLKTILRQDIGF 137
Query: 3228 FD-SVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFF 3052
FD +TG + ++ + ++ EK+ I V+ F G ALAF W L +
Sbjct: 138 FDVETNTGEVVGRMSGDTVHIQDAMGEKVGKFIQLVSTFVGGFALAFAKGWLLTLVMLTS 197
Query: 3051 SLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEEL 2872
+A +G + V + + + YA A ++ QT+G+ +TV S G+K I Y + +
Sbjct: 198 IPFLAMAGAAMALLVTRASSRGQAAYAKAATVVEQTIGSIRTVASFTGEKQAINSYKKYI 257
Query: 2871 KAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMI----YSGTLETAVVV----- 2719
+ K I++ + GV + S + ++ G MI Y+G V++
Sbjct: 258 TSAYKSSIQQGFSTGLGLGVMIYVFFSSYALAIWFGGKMILEKGYTGGSVINVIIIVVAG 317
Query: 2718 ----------------------------RDDNVIEKDETDYDVEVEVNGNISFKNVKFSY 2623
+ +I+ + + V ++ G+I K+V FSY
Sbjct: 318 SMSLGQTSPCVTAFAAGQAAAYKMFETIKRKPLIDAYDVNGKVLGDIRGDIELKDVHFSY 377
Query: 2622 PTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDM 2443
P RPD ++ G S + +G ALVG SGSGKSTV+ L+ +Y+ +G + IDG++L +
Sbjct: 378 PARPDEEIFDGFSLFIPSGATAALVGESGSGKSTVINLIERFYDPKAGEVLIDGINLKEF 437
Query: 2442 NIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIK 2263
+K +R IG+V QEPVLF+++I ENI +G N +L EI A ANA F+ + P+G+
Sbjct: 438 QLKWIRSKIGLVCQEPVLFSSSIMENIAYGKENATLQEIKVATELANAAKFINNLPQGLD 497
Query: 2262 TIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRT 2083
T VGE GTQLSGGQKQRIAIAR ++++P++LLLDEATSALD ESE+VVQ+AL+ RT
Sbjct: 498 TKVGEHGTQLSGGQKQRIAIARAILKDPRVLLLDEATSALDTESERVVQEALDRVMVNRT 557
Query: 2082 TIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKR-GVYNDLVQAQLLESHDDHEEL 1906
T+VVAHRLST+RNA I V+ G++VE G+H EL+ G Y+ L++ Q E + H+
Sbjct: 558 TVVVAHRLSTVRNADMIAVIHSGKMVEKGSHSELLKDSVGAYSQLIRCQ--EINKGHDAK 615
Query: 1905 PPLAARQLSQELSPLH----SYAIQRSTS---NDAGVHDDDM-------------ERILD 1786
P A S S L+ I TS N + H ++ +R+
Sbjct: 616 PSDMASGSSFRNSNLNISREGSVISGGTSSFGNSSRHHSLNVLGLFAGLDLGSGSQRVGQ 675
Query: 1785 E----LSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAM 1618
E S+E +K +L I +P+ L + +AI G +P+ LI R E F
Sbjct: 676 EETGTTSQEPLRKVSLTRIAALNKPEIPVLLLGTVVAAINGAIFPLFGILISRVIEAFFK 735
Query: 1617 IGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAF 1438
+ + S WA+ F+ L V + Q Y F +L R++ F + + ++
Sbjct: 736 PADQLKKDSRFWAIIFVALGVTSLIVSPSQMYLFAVAGGKLIRRIQSMCFEKAVHMEVSW 795
Query: 1437 YDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLM 1258
+D+P +S+ + RL+TD++ ++A V D L + + + + A W++ L +L+
Sbjct: 796 FDEPENSSGTMGARLSTDAALIRALVGDALSLAVQNAASAASGLIIAFTASWELALIILV 855
Query: 1257 FFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEH 1078
P + +E +++ A +A+ ++RTV + E+K+M + ++
Sbjct: 856 MLPLIGINGFLQVKFMKGFSADAKSKYEEASQVANDAVGSIRTVASFCAEEKVMQMYNKQ 915
Query: 1077 LQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSM 898
+ K K+ I G G S VY+ SF L + +D + V L+M
Sbjct: 916 CEGPIKDGVKQGFISGLGFGFSFFILFCVYATSFYAAARLVEDGKTTFIDVFQVFFALTM 975
Query: 897 TANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGK--KNIEKGEIIGENVQF 724
A ++ + PD KA AA IF + + + S G +N+ KG+I ++ F
Sbjct: 976 AAIGISQSSTFAPDSSKAKVAAASIFAIIDRKSKIDSSDETGTVLENV-KGDIELRHLSF 1034
Query: 723 HYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVE 544
Y RP I + L + GKT+ALVG SG GKST+ISLL+RFY G++ +D ++
Sbjct: 1035 TYPARPGIQIFRDLCLTIRAGKTVALVGESGSGKSTVISLLQRFYDPDSGQITLDGVELK 1094
Query: 543 DINLNHLRSNLALVSQEPTLFNCSIRENLLYGL--TRSVPQLELEKALQTANAFNFVFQF 370
+ L LR + LV QEP LFN +IR N+ YG + + E+ A + ANA F+
Sbjct: 1095 KLQLKWLRQQMGLVGQEPVLFNDTIRANIAYGKGSEEAATESEIIAAAELANAHKFISSI 1154
Query: 369 PQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTA 190
QG DT+VGE+G QLSGGQKQR+AIARAI++ PK+LLLDEATSALD++SE++VQ+ALD
Sbjct: 1155 QQGYDTVVGEKGIQLSGGQKQRVAIARAIVKEPKILLLDEATSALDAESERLVQDALDRV 1214
Query: 189 SERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLR-KRSIYWRLVQ 37
+TVVVAHRLST+ NAD IA++KNG +AE GTHE L++ +Y LVQ
Sbjct: 1215 IVNRTTVVVAHRLSTIKNADVIAIVKNGVIAENGTHETLIKIDGGVYASLVQ 1266
Score = 282 bits (722), Expect = 4e-74
Identities = 188/570 (32%), Positives = 293/570 (50%), Gaps = 4/570 (0%)
Frame = -1
Query: 1722 DYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFA--MIGEDMLYYSHLWALSFMFLAVFR 1549
D + G+ GV P++ L + F +D++ L F++L + R
Sbjct: 41 DVFLMICGSLGAIGNGVCLPLMTLLFGDLIDSFGKNQNNKDIVDVVSKVCLKFVYLGLGR 100
Query: 1548 PLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVK 1369
+ Q + E+ + ++R +L F+D ++ + R++ D+ +++
Sbjct: 101 LGAAFLQVACWMITGERQAAKIRSNYLKTILRQDIGFFDVETNTG-EVVGRMSGDTVHIQ 159
Query: 1368 AAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQED 1189
A+ +++G I V A W +TL +L P A
Sbjct: 160 DAMGEKVGKFIQLVSTFVGGFALAFAKGWLLTLVMLTSIPFLAMAGAAMALLVTRASSRG 219
Query: 1188 TIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSL 1009
A+ + + + ++RTV + E + ++ +++ +KS ++ G G+ +
Sbjct: 220 QAAYAKAATVVEQTIGSIRTVASFTGEKQAINSYKKYITSAYKSSIQQGFSTGLGLGVMI 279
Query: 1008 SCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAG 829
F Y+++ FG + L K V++ + + G + + + AA
Sbjct: 280 YVFFSSYALAIWFGGKMILEKGYTGGSVINVIIIVVAGSMSLGQTSPCVTAFAAGQAAAY 339
Query: 828 LIFHLFTYPATMPFSSSDGKKNIE-KGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTL 652
+F + +GK + +G+I ++V F Y RPD I +G +L + G T
Sbjct: 340 KMFETIKRKPLIDAYDVNGKVLGDIRGDIELKDVHFSYPARPDEEIFDGFSLFIPSGATA 399
Query: 651 ALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCS 472
ALVG SG GKST+I+L+ERFY GEV ID N+++ L +RS + LV QEP LF+ S
Sbjct: 400 ALVGESGSGKSTVINLIERFYDPKAGEVLIDGINLKEFQLKWIRSKIGLVCQEPVLFSSS 459
Query: 471 IRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIA 292
I EN+ YG + Q E++ A + ANA F+ PQGLDT VGE G QLSGGQKQRIAIA
Sbjct: 460 IMENIAYGKENATLQ-EIKVATELANAAKFINNLPQGLDTKVGEHGTQLSGGQKQRIAIA 518
Query: 291 RAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLK 112
RAIL++P+VLLLDEATSALD++SE+VVQ ALD +TVVVAHRLSTV NAD IAV+
Sbjct: 519 RAILKDPRVLLLDEATSALDTESERVVQEALDRVMVNRTTVVVAHRLSTVRNADMIAVIH 578
Query: 111 NGKVAEQGTHEELLRKR-SIYWRLVQKQGI 25
+GK+ E+G+H ELL+ Y +L++ Q I
Sbjct: 579 SGKMVEKGSHSELLKDSVGAYSQLIRCQEI 608
Score = 278 bits (711), Expect = 7e-73
Identities = 170/524 (32%), Positives = 264/524 (49%), Gaps = 44/524 (8%)
Frame = -1
Query: 3363 FFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSV--STGHLSTVL 3190
F G I + Q + G R++ + + + +FD S+G + L
Sbjct: 751 FVALGVTSLIVSPSQMYLFAVAGGKLIRRIQSMCFEKAVHMEVSWFDEPENSSGTMGARL 810
Query: 3189 NDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAG 3010
+ + R + + ++L + G +AF W LA + I +GF+
Sbjct: 811 STDAALIRALVGDALSLAVQNAASAASGLIIAFTASWELALIILVMLPLIGINGFLQVKF 870
Query: 3009 VMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMY 2830
+ + + Y A +A +G+ +TV S ++ ++ Y ++ + K G+++ +
Sbjct: 871 MKGFSADAKSKYEEASQVANDAVGSIRTVASFCAEEKVMQMYNKQCEGPIKDGVKQGFIS 930
Query: 2829 SISRGVTYFFCNSLNTVVLYVGATMIYSGTLET--------------------------- 2731
+ G ++F + Y A ++ G
Sbjct: 931 GLGFGFSFFILFCVYATSFYAAARLVEDGKTTFIDVFQVFFALTMAAIGISQSSTFAPDS 990
Query: 2730 -----------AVVVRDDNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGIS 2584
A++ R + DET +E V G+I +++ F+YP RP Q+ + +
Sbjct: 991 SKAKVAAASIFAIIDRKSKIDSSDETGTVLE-NVKGDIELRHLSFTYPARPGIQIFRDLC 1049
Query: 2583 FDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVS 2404
++ G+ +ALVG SGSGKSTV+ LL +Y+ DSG I +DG++L + +K LR+ +G+V
Sbjct: 1050 LTIRAGKTVALVGESGSGKSTVISLLQRFYDPDSGQITLDGVELKKLQLKWLRQQMGLVG 1109
Query: 2403 QEPVLFNTTIEENIRFGNPN---VSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQL 2233
QEPVLFN TI NI +G + + EI A ANA+ F+ S +G T+VGE+G QL
Sbjct: 1110 QEPVLFNDTIRANIAYGKGSEEAATESEIIAAAELANAHKFISSIQQGYDTVVGEKGIQL 1169
Query: 2232 SGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLST 2053
SGGQKQR+AIAR +V+ PKILLLDEATSALD ESE++VQ AL+ RTT+VVAHRLST
Sbjct: 1170 SGGQKQRVAIARAIVKEPKILLLDEATSALDAESERLVQDALDRVIVNRTTVVVAHRLST 1229
Query: 2052 IRNASKIIVMQKGEIVEVGNHDELI-AKRGVYNDLVQAQLLESH 1924
I+NA I +++ G I E G H+ LI GVY LVQ + S+
Sbjct: 1230 IKNADVIAIVKNGVIAENGTHETLIKIDGGVYASLVQLHMTASN 1273
>gi|15232978|ref|NP_189480.1| P-glycoprotein, putative [Arabidopsis
thaliana]
gi|9294574|dbj|BAB02855.1| multidrug resistance p-glycoprotein; ABC
transporter-like protein [Arabidopsis thaliana]
Length = 1225
Score = 648 bits (1672), Expect = 0.0
Identities = 413/1241 (33%), Positives = 661/1241 (52%), Gaps = 52/1241 (4%)
Frame = -1
Query: 3597 IRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPAD 3418
IR +F + + L LG++ ++ GF P + + ++ +NN D
Sbjct: 8 IRSIFMHADGVDWMLMALGLIGAVGDGFITPIIFFICSKL----------LNNVGGSSFD 57
Query: 3417 LEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKD 3238
E + + +V+ CA ++ ++ G+ ++R++Y+ +L++D
Sbjct: 58 DETFMQTVAKNAVALVY----VACASWVICFIEGYCWTRTGERQAAKMREKYLKAVLRQD 113
Query: 3237 AQYFDS--VSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASY 3064
YFD ST + T ++ + ++ +EK+ + + F + F WRL
Sbjct: 114 VGYFDLHVTSTSDVITSVSSDSLVIQDFLSEKLPNFLMNTSAFVASYIVGFLLLWRLTIV 173
Query: 3063 GIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERY 2884
G F + + G + +++ + K Y AGSIA Q + + +TV + +K IE++
Sbjct: 174 GFPFIILLLIPGLMYGRALIRISMKIREEYNEAGSIAEQVISSVRTVYAFGSEKKMIEKF 233
Query: 2883 TEELKAGEKYGIRRALMYSI---SRGVTYFFCNSLNTVVLYVGATMIYS-----GTLETA 2728
+ L+ K G+R+ L I S G+TY L + G+ M+ + GT+ +
Sbjct: 234 STALQGSVKLGLRQGLAKGIAIGSNGITYAIWGFLT----WYGSRMVMNHGSKGGTVSSV 289
Query: 2727 VV-----------------------VRDDNV---------IEKDETDYDVEVEVNGNISF 2644
+V V + + I+ D + + + G + F
Sbjct: 290 IVCVTFGGTSLGQSLSNLKYFSEAFVVGERIMKVINRVPGIDSDNLEGQILEKTRGEVEF 349
Query: 2643 KNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFID 2464
+VKF+YP+RP+ + + V +G+ +ALVG SGSGKSTV+ LL +Y+ +G I ID
Sbjct: 350 NHVKFTYPSRPETPIFDDLCLRVPSGKTVALVGGSGSGKSTVISLLQRFYDPIAGEILID 409
Query: 2463 GMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVC 2284
G+ +N + +K LR +G+VSQEPVLF T+I+ENI FG + S+ E+ A + +NA+ F+
Sbjct: 410 GLPINKLQVKWLRSQMGLVSQEPVLFATSIKENILFGKEDASMDEVVEAAKASNAHSFIS 469
Query: 2283 SFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALE 2104
FP +T VGERG QLSGGQKQRIAIAR ++++P ILLLDEATSALD+ESE+VVQ+AL+
Sbjct: 470 QFPNSYQTQVGERGVQLSGGQKQRIAIARAIIKSPIILLLDEATSALDSESERVVQEALD 529
Query: 2103 NASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAK-RGVYNDLVQAQLLES 1927
NAS GRTTIV+AHRLSTIRNA I V+ G I+E G+H+EL+ K G Y LV+ Q +++
Sbjct: 530 NASIGRTTIVIAHRLSTIRNADVICVVHNGRIIETGSHEELLEKLDGQYTSLVRLQQVDN 589
Query: 1926 HD-DHEELPPLAARQLSQELSPLHSYAIQRSTSNDAGVHDDDMERILDELSKEGAKK--S 1756
+ DH + A LS++L I ++SN + R LS + K
Sbjct: 590 KESDHISVEEGQASSLSKDLKYSPKEFIHSTSSN--------IVRDFPNLSPKDGKSLVP 641
Query: 1755 NLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDML-YYSHLWA 1579
+ + ++ RP++ G+A+ G PI + + + D + + ++
Sbjct: 642 SFKRLMSMNRPEWKHALYGCLGAALFGAVQPIYSYSSGSMVSVYFLASHDQIKEKTRIYV 701
Query: 1578 LSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSN 1399
L F+ LA+F L+ Q+Y F + E L+ R+R + +L+ ++D +S+ + +
Sbjct: 702 LLFVGLALFTFLSNISQHYGFAYMGEYLTKRIRERMLGKILTFEVNWFDKDENSSGAICS 761
Query: 1398 RLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXX 1219
RL D++ V++ V DR+ ++ T+ A+SI + W+ ++ ++ P
Sbjct: 762 RLAKDANMVRSLVGDRMSLLVQTISAVSITCAIGLVISWRFSIVMMSVQPVIVVCFYTQR 821
Query: 1218 XXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAI 1039
+ + S++ A EA+ N+RT+ A + +++I++L+ + K +++
Sbjct: 822 VLLKSMSRNAIKGQDESSKLAAEAVSNIRTITAFSSQERIINLLKMVQEGPRKDSARQSW 881
Query: 1038 IQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLP 859
+ G G S S V +++F +G L ++ + + + + T + A
Sbjct: 882 LAGIMLGTSQSLITCVSALNFWYGGKLIADGKMMSKEFLEIFLIFASTGRVIAEAGTMTK 941
Query: 858 DYKKAVHAAGLIFHLFTYPATMPFSSSDG--KKNIEKGEIIGENVQFHYDQRPDRMILNG 685
D K A +F + T+ + DG K + KG+I NV F Y RPD +I
Sbjct: 942 DLVKGSDAVASVFAVLDRNTTIEPENPDGYVPKKV-KGQISFSNVDFAYPTRPDVIIFQN 1000
Query: 684 VNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLAL 505
++ ++ GK+ A+VGPSG GKSTIISL+ERFY + G VKID ++ +L LR ++AL
Sbjct: 1001 FSIDIEDGKSTAIVGPSGSGKSTIISLIERFYDPLKGIVKIDGRDIRSCHLRSLRQHIAL 1060
Query: 504 VSQEPTLFNCSIRENLLY-GLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQ 328
VSQEPTLF +IREN++Y G + + + E+ +A + ANA +F+ G DT G+RG Q
Sbjct: 1061 VSQEPTLFAGTIRENIMYGGASNKIDESEIIEAAKAANAHDFITSLSNGYDTCCGDRGVQ 1120
Query: 327 LSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLS 148
LSGGQKQRIAIARA+L+NP VLLLDEATSALDS SE VVQ+AL+ ++VV+AHRLS
Sbjct: 1121 LSGGQKQRIAIARAVLKNPSVLLLDEATSALDSQSESVVQDALERLMVGRTSVVIAHRLS 1180
Query: 147 TVVNADSIAVLKNGKVAEQGTHEELLRK--RSIYWRLVQKQ 31
T+ D+IAVL+NG V E G H LL K + Y+ LV Q
Sbjct: 1181 TIQKCDTIAVLENGAVVECGNHSSLLAKGPKGAYFSLVSLQ 1221
>gi|25407562|pir||H85202 hypothetical protein AT4g18050 [imported] -
Arabidopsis thaliana
gi|7268557|emb|CAB78807.1| multidrug resistance
protein/P-glycoprotein-like [Arabidopsis thaliana]
Length = 1323
Score = 648 bits (1671), Expect = 0.0
Identities = 427/1267 (33%), Positives = 646/1267 (50%), Gaps = 86/1267 (6%)
Frame = -1
Query: 3615 SQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNK 3436
+Q SF ++ F + + L +G + + G QPFM+ FG+ + NA
Sbjct: 13 NQKVSFFKL-FSFADKTDVVLMTVGTIAAAGNGLTQPFMTLIFGQ-------LINAFG-- 62
Query: 3435 TIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYIS 3256
T DP + R + +V F + A LQ + G+ + +R Y+
Sbjct: 63 TTDP-------DHMVREVWKVAVKFIYLAVYSCVVAFLQVSCWMVTGERQSATIRGLYLK 115
Query: 3255 RLLKKDAQYFDS-VSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDW 3079
+L++D YFD+ +TG + ++ + ++ EK+ + F G A+AFY
Sbjct: 116 TILRQDIGYFDTETNTGEVIGRMSGDTILIQDAMGEKVGKFTQLLCTFLGGFAIAFYKGP 175
Query: 3078 RLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKT 2899
LA I +G S + K G+ YA AG++ QT+GA +TV + G+K
Sbjct: 176 LLAGVLCSCIPLIVIAGAAMSLIMSKMAGRGQVAYAEAGNVVEQTVGAIRTVVAFTGEKQ 235
Query: 2898 EIERYTEELKAGEKYGIRRALMYSISRG--VTYFFCNSLNTVVLYVGATMI----YSGTL 2737
E+Y +L+ K +++ L+ G + FC+ + ++ GA +I Y+G
Sbjct: 236 ATEKYESKLEIAYKTVVQQGLISGFGLGTMLAVIFCSY--GLAVWYGAKLIMEKGYNGGQ 293
Query: 2736 ETAVV---------------------------------VRDDNVIEKDETDYDVEVEVNG 2656
V+ ++ I+ + V ++ G
Sbjct: 294 VINVIFAVLTGGMSLGQTSPSLNAFAAGRAAAFKMFETIKRSPKIDAYDMSGSVLEDIRG 353
Query: 2655 NISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGN 2476
+I K+V F YP RPD Q+ G S V NG+ +ALVG SGSGKSTV+ L+ +Y+ +SG
Sbjct: 354 DIELKDVYFRYPARPDVQIFAGFSLFVPNGKTVALVGQSGSGKSTVISLIERFYDPESGQ 413
Query: 2475 IFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAY 2296
+ ID +DL + +K +R IG+VSQEPVLF TTI+ENI +G + + EI A+ ANA
Sbjct: 414 VLIDNIDLKKLQLKWIRSKIGLVSQEPVLFATTIKENIAYGKEDATDQEIRTAIELANAA 473
Query: 2295 DFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQ 2116
F+ P+G+ T+VGE GTQ+SGGQKQR+AIAR +++NPKILLLDEATSALD ESE++VQ
Sbjct: 474 KFIDKLPQGLDTMVGEHGTQMSGGQKQRLAIARAILKNPKILLLDEATSALDAESERIVQ 533
Query: 2115 KALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIA-KRGVYNDLVQAQ 1939
AL N RTT+VVAHRL+TIR A I V+ +G+IVE G HDE+I G Y+ LV+ Q
Sbjct: 534 DALVNLMSNRTTVVVAHRLTTIRTADVIAVVHQGKIVEKGTHDEMIQDPEGAYSQLVRLQ 593
Query: 1938 LLESHDDHEELPPLAARQLSQELSPLHSYAIQRSTSNDA----------------GVHDD 1807
+ E P + + + S S A++RS S ++ GV+ +
Sbjct: 594 EGSKEEATESERPETSLDVERSGSLRLSSAMRRSVSRNSSSSRHSFSLASNMFFPGVNVN 653
Query: 1806 DMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEG 1627
+ + DE + KK +L+ + +P+ L + + + G +PI L+ +
Sbjct: 654 QTDEMEDEENNVRHKKVSLKRLAHLNKPEIPVLVLGSIAAMVHGTVFPIFGLLLSSSINM 713
Query: 1626 FAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLP 1447
F + + SH WAL ++ L + + + Y+FG +L R+R F ++
Sbjct: 714 FYEPAKILKKDSHFWALIYIALGLTNFVMIPVPNYFFGIAGGKLIKRIRSMCFDKVVHQE 773
Query: 1446 CAFYDDPNHS---------------------------ATRLSNRLNTDSSNVKAAVDDRL 1348
+++DD +S RL +TD+S V++ V D L
Sbjct: 774 ISWFDDTANSRYYNFIYIINRRILYVLILIFICVLLPPVRLERECSTDASTVRSLVGDAL 833
Query: 1347 GCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENS 1168
++ + ++ + A W + L VL P + +E +
Sbjct: 834 ALIVQNIATVTTGLIIAFTANWILALIVLALSPFIVIQGYAQTKFLTGFSADAKAMYEEA 893
Query: 1167 NRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVY 988
++ A +A+ ++RTV + E+K+M L + K+ + ++ GA G S +
Sbjct: 894 SQVANDAVSSIRTVASFCAEEKVMDLYQQKCDGPKKNGVRLGLLSGAGFGFSFFFLYCIN 953
Query: 987 SVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFT 808
V F G L + + + V L++ A +A PD KA +A IF +
Sbjct: 954 CVCFVSGAGLIQIGKATFGEVFKVFFALTIMAIGVSQTSAMAPDSNKAKDSAASIFDILD 1013
Query: 807 YPATMPFSSSDGK--KNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPS 634
+ SS +G +N+ G+I +V F Y RPD I + L + GKT+ALVG S
Sbjct: 1014 STPKIDSSSDEGTTLQNV-NGDIEFRHVSFRYPMRPDVQIFRDLCLTIPSGKTVALVGES 1072
Query: 633 GCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLL 454
G GKST+IS++ERFY+ G++ ID ++ L+ LR + LVSQEP LFN +IR N+
Sbjct: 1073 GSGKSTVISMIERFYNPDSGKILIDQVEIQTFKLSWLRQQMGLVSQEPILFNETIRSNIA 1132
Query: 453 YGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRN 274
YG T + E+ A + ANA NF+ PQG DT VGERG QLSGGQKQRIAIARAIL++
Sbjct: 1133 YGKTGGATEEEIIAAAKAANAHNFISSLPQGYDTSVGERGVQLSGGQKQRIAIARAILKD 1192
Query: 273 PKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAE 94
PK+LLLDEATSALD++SE+VVQ+ALD +TVVVAHRL+T+ NAD IAV+KNG +AE
Sbjct: 1193 PKILLLDEATSALDAESERVVQDALDRVMVNRTTVVVAHRLTTIKNADVIAVVKNGVIAE 1252
Query: 93 QGTHEEL 73
+G HE L
Sbjct: 1253 KGRHETL 1259
Score = 268 bits (686), Expect = 5e-70
Identities = 180/571 (31%), Positives = 288/571 (49%), Gaps = 5/571 (0%)
Frame = -1
Query: 1728 RPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYYSHLW--ALSFMFLAV 1555
+ D + + +A G++ P + + + F D + +W A+ F++LAV
Sbjct: 27 KTDVVLMTVGTIAAAGNGLTQPFMTLIFGQLINAFGTTDPDHMV-REVWKVAVKFIYLAV 85
Query: 1554 FRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSN 1375
+ + + Q + E+ S +R +L ++D ++ + R++ D+
Sbjct: 86 YSCVVAFLQVSCWMVTGERQSATIRGLYLKTILRQDIGYFDTETNTG-EVIGRMSGDTIL 144
Query: 1374 VKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMF-FPXXXXXXXXXXXXXXXAI 1198
++ A+ +++G + A Y + VL P
Sbjct: 145 IQDAMGEKVGKFTQLLCTFLGGFAIA-FYKGPLLAGVLCSCIPLIVIAGAAMSLIMSKMA 203
Query: 1197 QEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANG 1018
+A+ + + + +RTV A E + L+ +K+ ++ +I G G
Sbjct: 204 GRGQVAYAEAGNVVEQTVGAIRTVVAFTGEKQATEKYESKLEIAYKTVVQQGLISGFGLG 263
Query: 1017 LSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVH 838
L+ Y ++ +G L + K V+ + G + L +
Sbjct: 264 TMLAVIFCSYGLAVWYGAKLIMEKGYNGGQVINVIFAVLTGGMSLGQTSPSLNAFAAGRA 323
Query: 837 AAGLIFHLFTY-PATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPG 661
AA +F P + S +G+I ++V F Y RPD I G +L V G
Sbjct: 324 AAFKMFETIKRSPKIDAYDMSGSVLEDIRGDIELKDVYFRYPARPDVQIFAGFSLFVPNG 383
Query: 660 KTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLF 481
KT+ALVG SG GKST+ISL+ERFY G+V ID+ +++ + L +RS + LVSQEP LF
Sbjct: 384 KTVALVGQSGSGKSTVISLIERFYDPESGQVLIDNIDLKKLQLKWIRSKIGLVSQEPVLF 443
Query: 480 NCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRI 301
+I+EN+ YG + Q E+ A++ ANA F+ + PQGLDT+VGE G Q+SGGQKQR+
Sbjct: 444 ATTIKENIAYGKEDATDQ-EIRTAIELANAAKFIDKLPQGLDTMVGEHGTQMSGGQKQRL 502
Query: 300 AIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIA 121
AIARAIL+NPK+LLLDEATSALD++SE++VQ+AL +TVVVAHRL+T+ AD IA
Sbjct: 503 AIARAILKNPKILLLDEATSALDAESERIVQDALVNLMSNRTTVVVAHRLTTIRTADVIA 562
Query: 120 VLKNGKVAEQGTHEELLR-KRSIYWRLVQKQ 31
V+ GK+ E+GTH+E+++ Y +LV+ Q
Sbjct: 563 VVHQGKIVEKGTHDEMIQDPEGAYSQLVRLQ 593
>gi|4204793|gb|AAD10836.1| P-glycoprotein [Solanum tuberosum]
Length = 1313
Score = 647 bits (1670), Expect = 0.0
Identities = 426/1251 (34%), Positives = 647/1251 (51%), Gaps = 65/1251 (5%)
Frame = -1
Query: 3588 VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEK 3409
+F+ + + L ++G L + + G P F ++ + N D++K
Sbjct: 58 LFRFADGLDCVLMIIGSLGAFVHGCSLPLFLRFFADLVNSFGSYAN----------DVDK 107
Query: 3408 AYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQY 3229
+E + + F+F + G A + + + + + G+ T ++R +Y+ L +D QY
Sbjct: 108 MTQE----VLKYAFYFLVVGAAIWASSWAEISCWMWTGERQTTKMRIKYLEAALNQDIQY 163
Query: 3228 FDS-VSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFF 3052
FD+ V T + + +N + ++ +EK+ I ++ F G + F W+LA +
Sbjct: 164 FDTEVRTSDVVSAINTDAVVVQDAISEKLGNFIHYMATFLSGFVVGFTAVWQLALVTLAV 223
Query: 3051 SLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEEL 2872
IA G I + K + + + AG+I QT+ +TV G+ ++ YT L
Sbjct: 224 VPLIAVIGAIYTVTSAKLSSQSQEALSKAGNIVEQTVVQIRTVLVFVGEAKALQAYTAAL 283
Query: 2871 KAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIY----SGTLETA-------- 2728
+ +K G + + G TYF ++L+ G ++ +G L A
Sbjct: 284 RVSQKIGYKSGFSKGLGLGATYFTVFCCYALLLWYGGYLVRHHFTNGGLAIATMFAVMIG 343
Query: 2727 --------------------------VVVRDDNVIEKDETDYDVEVEVNGNISFKNVKFS 2626
++ +V +T +++ V+G + KNV+FS
Sbjct: 344 GLALGQSAPSMTAFAKARVAAAKIFRIIDHKPSVDRNAKTGLELDT-VSGQLELKNVEFS 402
Query: 2625 YPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLND 2446
YP+RP+ ++L + V G+ IALVG+SGSGKSTVV L+ +Y+ SG + +DG D+
Sbjct: 403 YPSRPEIKILNNFNLVVPAGKTIALVGSSGSGKSTVVSLIERFYDPTSGQLMLDGNDIKT 462
Query: 2445 MNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGI 2266
+ +K LR+ IG+VSQEP LF T+I+ENI G P+ + EI A R ANA+ FV P G
Sbjct: 463 LKLKWLRQQIGLVSQEPALFATSIKENILLGRPDATQIEIEEAARVANAHSFVIKLPDGF 522
Query: 2265 KTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGR 2086
T VGERG QLSGGQKQRIAIAR +++NP ILLLDEATSALD+ESE++VQ+AL+ GR
Sbjct: 523 DTQVGERGLQLSGGQKQRIAIARAMLKNPAILLLDEATSALDSESEKLVQEALDRFMIGR 582
Query: 2085 TTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAK--RGVYNDLVQAQ--------- 1939
TT+V+AHRLSTIR A + V+Q+G + E+G+HDEL++K G+Y L++ Q
Sbjct: 583 TTLVIAHRLSTIRKADLVAVLQQGSVSEIGSHDELMSKGENGMYAKLIKMQEAAHETALS 642
Query: 1938 ------LLESHDDHEELPPLAARQLSQELSPLHSYAIQRSTSNDAGVHDDDMERILDELS 1777
S + P+ R S SP STS+ + D +E
Sbjct: 643 NARKSSARPSSARNSVSSPIITRNSSYGRSPYSRRLSDFSTSDFSLSLDAAYSNYRNEKL 702
Query: 1776 KEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQG-----VSYPILAQLIVRTYEGFAMIG 1612
+ S+ + K P++ + I GS I G +Y + A L V A +
Sbjct: 703 AFKDQASSFGRLAKMNSPEWTYALIGSIGSVICGSLSAFFAYVLSAVLSVYYNPDHAYMS 762
Query: 1611 EDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYD 1432
E + Y +L +F L Q+YY+ V E L+ R+R K + +L + A++D
Sbjct: 763 EQIAKYCYLLIGVSSAALIFNTL----QHYYWDVVGENLTKRVREKMLAAVLKMEMAWFD 818
Query: 1431 DPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFF 1252
+ ++R++ RL+ D++NV++A+ DR+ ++ + +A T + W++ L ++ F
Sbjct: 819 QEENDSSRIAARLSLDANNVRSAIGDRISVIMQNSALMLVACTAGFVLQWRLALVLIGVF 878
Query: 1251 PXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQ 1072
P + A + + A EA+ NVRTV A N E KI++L LQ
Sbjct: 879 PVVVAATVLQKMFMKGFSGDLEAAHAKATQLAGEAVANVRTVAAFNSETKIVNLFDSSLQ 938
Query: 1071 KIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTA 892
+ F + I G+ G++ Y++ + ++L T V M L ++A
Sbjct: 939 TPLRRCFWKGQIAGSGYGIAQFLLYSSYALGLWYASWLVKHGISDFSKTIRVFMVLMVSA 998
Query: 891 NMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIE--KGEIIGENVQFHY 718
N A PD+ K A +F L + D + +GE+ ++V F Y
Sbjct: 999 NGAAETLTLAPDFIKGGRAMRSVFELLDRKTEVEPDDPDATAVPDRLRGEVEFKHVDFSY 1058
Query: 717 DQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDI 538
RPD I +NL+ GKTLALVGPSGCGKS++ISL+ERFY G V ID +++
Sbjct: 1059 PTRPDVSIFRDLNLRARAGKTLALVGPSGCGKSSVISLIERFYEPSSGRVIIDGKDIRKY 1118
Query: 537 NLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGL 358
NL LR ++A+V QEP LF +I EN+ YG S + E+ +A ANA F+ P G
Sbjct: 1119 NLKSLRRHIAVVPQEPCLFATTIYENIAYG-HESATEAEITEAATLANAHKFISALPDGY 1177
Query: 357 DTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERL 178
T VGERG QLSGGQKQRIAIARA LR +++LLDEATSALD++SE+ VQ ALD A
Sbjct: 1178 KTFVGERGVQLSGGQKQRIAIARAFLRKAELMLLDEATSALDAESERCVQEALDRACAGK 1237
Query: 177 STVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRS--IYWRLVQKQ 31
+T+VVAHRLST+ NA IAV+ +GKVAEQG+H LL+ S IY R++Q Q
Sbjct: 1238 TTIVVAHRLSTIRNAHVIAVIDDGKVAEQGSHSHLLKNYSDGIYARMIQLQ 1288
Score = 296 bits (758), Expect = 2e-78
Identities = 193/577 (33%), Positives = 297/577 (51%), Gaps = 7/577 (1%)
Frame = -1
Query: 1722 DYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDM-LYYSHLWALSFMFLAVFRP 1546
D + I G+ + G S P+ + F D+ + +F FL V
Sbjct: 66 DCVLMIIGSLGAFVHGCSLPLFLRFFADLVNSFGSYANDVDKMTQEVLKYAFYFLVVGAA 125
Query: 1545 L--TLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNV 1372
+ + + + + E+ +T++RIK L+ ++D ++ +S +NTD+ V
Sbjct: 126 IWASSWAEISCWMWTGERQTTKMRIKYLEAALNQDIQYFDTEVRTSDVVS-AINTDAVVV 184
Query: 1371 KAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQE 1192
+ A+ ++LG I + W++ L L P +
Sbjct: 185 QDAISEKLGNFIHYMATFLSGFVVGFTAVWQLALVTLAVVPLIAVIGAIYTVTSAKLSSQ 244
Query: 1191 DTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLS 1012
A + + + +RTV E K + + L+ K +K +G G +
Sbjct: 245 SQEALSKAGNIVEQTVVQIRTVLVFVGEAKALQAYTAALRVSQKIGYKSGFSKGLGLGAT 304
Query: 1011 LSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMA-GSAAAYLPDYKKAVHA 835
Y++ +G YL +R + M M +A G +A + + KA A
Sbjct: 305 YFTVFCCYALLLWYGGYL-VRHHFTNGGLAIATMFAVMIGGLALGQSAPSMTAFAKARVA 363
Query: 834 AGLIFHLFTYPATMPFSSSDG-KKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGK 658
A IF + + ++ ++ G + + G++ +NV+F Y RP+ ILN NL V GK
Sbjct: 364 AAKIFRIIDHKPSVDRNAKTGLELDTVSGQLELKNVEFSYPSRPEIKILNNFNLVVPAGK 423
Query: 657 TLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFN 478
T+ALVG SG GKST++SL+ERFY G++ +D +++ + L LR + LVSQEP LF
Sbjct: 424 TIALVGSSGSGKSTVVSLIERFYDPTSGQLMLDGNDIKTLKLKWLRQQIGLVSQEPALFA 483
Query: 477 CSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIA 298
SI+EN+L G Q+E+E+A + ANA +FV + P G DT VGERG QLSGGQKQRIA
Sbjct: 484 TSIKENILLG-RPDATQIEIEEAARVANAHSFVIKLPDGFDTQVGERGLQLSGGQKQRIA 542
Query: 297 IARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAV 118
IARA+L+NP +LLLDEATSALDS+SEK+VQ ALD +T+V+AHRLST+ AD +AV
Sbjct: 543 IARAMLKNPAILLLDEATSALDSESEKLVQEALDRFMIGRTTLVIAHRLSTIRKADLVAV 602
Query: 117 LKNGKVAEQGTHEELLRK--RSIYWRLVQKQGIQVET 13
L+ G V+E G+H+EL+ K +Y +L++ Q ET
Sbjct: 603 LQQGSVSEIGSHDELMSKGENGMYAKLIKMQEAAHET 639
>gi|15234323|ref|NP_192092.1| multidrug resistance P-glycoprotein,
putative [Arabidopsis thaliana]
gi|25297454|pir||E85023 probable P-glycoprotein-like protein
[imported] - Arabidopsis thaliana
gi|4558552|gb|AAD22645.1| putative P-glycoprotein-like protein
[Arabidopsis thaliana]
gi|7268567|emb|CAB80676.1| putative P-glycoprotein-like protein
[Arabidopsis thaliana]
Length = 1230
Score = 647 bits (1668), Expect = 0.0
Identities = 409/1235 (33%), Positives = 636/1235 (51%), Gaps = 51/1235 (4%)
Frame = -1
Query: 3588 VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEK 3409
+F S + L ++G + ++ G C P M+ FGE+ ID +
Sbjct: 18 LFFFSDSTDVLLMIVGSIGAIANGVCSPLMTLLFGEL---------------IDAMGPNQ 62
Query: 3408 AYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQY 3229
EE +++V G A LQ A G+ R+R Y+ +L++D +
Sbjct: 63 NNEEIVERVSKVCLSLVYLGLGALGAAFLQVACWMITGERQAARIRSLYLKTILRQDIGF 122
Query: 3228 FD-SVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFF 3052
FD ++TG + ++ + + EK+ I ++ F G +AF W L +
Sbjct: 123 FDVEMTTGEVVGRMSGDTVLILDAMGEKVGKFIQLISTFVGGFVIAFLRGWLLTLVMLTS 182
Query: 3051 SLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEEL 2872
+A SG + V + + ++ YA A ++ QTLG+ +TV S G+K + Y E +
Sbjct: 183 IPLLAMSGAAIAIIVTRASSQEQAAYAKASNVVEQTLGSIRTVASFTGEKQAMSSYKELI 242
Query: 2871 KAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMI----YSG------------- 2743
K +++ + + GV + S + + G MI Y+G
Sbjct: 243 NLAYKSNVKQGFVTGLGLGVMFLVFFSTYALGTWFGGEMILRKGYTGGAVINVMVTVVSS 302
Query: 2742 --------------TLETAVVVRDDNVIEK----DETDYDVEV--EVNGNISFKNVKFSY 2623
T A + IE+ D D + +V ++ G I ++V FSY
Sbjct: 303 SIALGQASPCLTAFTAGKAAAYKMFETIEREPLIDTFDLNGKVLEDIRGEIELRDVCFSY 362
Query: 2622 PTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDM 2443
P RP +V G S + +G ALVG SGSGKSTV+ L+ +Y+ +SG + IDG+DL +
Sbjct: 363 PARPKEEVFGGFSLLIPSGTTTALVGESGSGKSTVISLIERFYDPNSGQVLIDGVDLKEF 422
Query: 2442 NIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIK 2263
+K +R IG+VSQEPVLF+++I ENI +G ++ EI A + ANA F+ P G++
Sbjct: 423 QLKWIRGKIGLVSQEPVLFSSSIMENIGYGKEGATVEEIQAASKLANAAKFIDKLPLGLE 482
Query: 2262 TIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRT 2083
T+VGE GTQLSGGQKQRIAIAR ++++P+ILLLDEATSALD ESE+VVQ+AL+ RT
Sbjct: 483 TLVGEHGTQLSGGQKQRIAIARAILKDPRILLLDEATSALDAESERVVQEALDRIMVNRT 542
Query: 2082 TIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIA-KRGVYNDLVQAQLLESHDDHEEL 1906
T++VAHRLST+RNA I V+ +G+IVE G+H EL+ G Y+ L++ Q + E+
Sbjct: 543 TVIVAHRLSTVRNADIIAVIHRGKIVEEGSHSELLKDHEGAYSQLLRLQEINKESKRLEI 602
Query: 1905 PPLAARQLSQELSPLHSYAIQRSTSNDAGVHDDDMERIL--------DELSKEGAKKSNL 1750
S + S N++ DDD +L ++S+E ++K +
Sbjct: 603 SD-------------GSISSGSSRGNNSTRQDDDSFSVLGLLAGQDSTKMSQELSQKVSF 649
Query: 1749 REIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYYSHLWALSF 1570
I +P+ L + A+ G +PI L + E F ++ S W++ F
Sbjct: 650 TRIAALNKPEIPILILGTLVGAVNGTIFPIFGILFAKVIEAFFKAPHELKRDSRFWSMIF 709
Query: 1569 MFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLN 1390
+ L V + Y F +L R+R F ++ + ++D+P +S+ + RL+
Sbjct: 710 VLLGVAAVIVYPTTNYLFAIAGGRLIRRIRSMCFEKVVHMEVGWFDEPGNSSGAMGARLS 769
Query: 1389 TDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXX 1210
D++ ++ V D L + V ++ + A W++ + +L+ P
Sbjct: 770 ADAALIRTLVGDSLCLSVKNVASLVTGLIIAFTASWEVAIIILVIIPFIGINGYIQIKFM 829
Query: 1209 XXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQG 1030
+ +E +++ A +A+ ++RTV + E+K+M + + + KS K+ +I G
Sbjct: 830 KGFSADAKAKYEEASQVANDAVGSIRTVASFCAEEKVMEMYKKRCEDTIKSGIKQGLISG 889
Query: 1029 AANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYK 850
G+S VY+ F G L D + V + L++TA A+++ PD
Sbjct: 890 VGFGISFFVLYSVYASCFYVGARLVKAGRTNFNDVFQVFLALTLTAVGISQASSFAPDSS 949
Query: 849 KAVHAAGLIFHLFTYPATMPFSSSDGK--KNIEKGEIIGENVQFHYDQRPDRMILNGVNL 676
K AA IF + + + G +N+ KG+I ++ F Y RPD + + L
Sbjct: 950 KGKGAAVSIFRIIDRISKIDSRDESGMVLENV-KGDIELCHISFTYQTRPDVQVFRDLCL 1008
Query: 675 KVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQ 496
+ G+T+ALVG SG GKST+ISLL+RFY G + +D ++ + L LR + LV Q
Sbjct: 1009 SIRAGQTVALVGESGSGKSTVISLLQRFYDPDSGHITLDGVELKKLRLKWLRQQMGLVGQ 1068
Query: 495 EPTLFNCSIRENLLYGL-TRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSG 319
EP LFN +IR N+ YG + E+ A + ANA F+ +G DT+VGERG QLSG
Sbjct: 1069 EPVLFNDTIRANIAYGKGGEEATEAEIIAASELANAHRFISSIQKGYDTVVGERGIQLSG 1128
Query: 318 GQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVV 139
GQKQR+AIARAI++ PK+LLLDEATSALD++SE+VVQ+ALD +T+VVAHRLST+
Sbjct: 1129 GQKQRVAIARAIVKEPKILLLDEATSALDAESERVVQDALDRVMVNRTTIVVAHRLSTIK 1188
Query: 138 NADSIAVLKNGKVAEQGTHEELLR-KRSIYWRLVQ 37
NAD IAV+KNG +AE+GTHE L+ + +Y LVQ
Sbjct: 1189 NADVIAVVKNGVIAEKGTHETLINIEGGVYASLVQ 1223
>gi|422285|pir||S30327 multidrug resistance protein 1 - Entamoeba
histolytica
gi|158971|gb|AAA29112.1| P-glycoprotein-1
Length = 1302
Score = 646 bits (1667), Expect = 0.0
Identities = 415/1269 (32%), Positives = 664/1269 (51%), Gaps = 80/1269 (6%)
Frame = -1
Query: 3597 IRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITN-AINNKTIDPA 3421
I+ +F+ + FE L ++G++ S+ G P + G+V V N + +I
Sbjct: 35 IKELFRYAGVFEIILLIIGIIGSIGVGCLNPLLMILTGDVVDTFVNGENFSKEGGSIKIT 94
Query: 3420 DLEKAYE---EYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRL 3250
E YE +N++V + LQ + + ++R Y L
Sbjct: 95 TEEMNYEIMNSISDTINKLVLKMLYFAIGNMVAGFLQTICFFVLSEYQGIKIRSLYFKAL 154
Query: 3249 LKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLA 3070
L++D +FD TG L++ + +++++ ++ + K + + F G + F W L
Sbjct: 155 LRQDPGWFDCHKTGELTSKIINDIQKIQDGMSLKFGRLFQTFSSFITGYLIGFIKCWDLT 214
Query: 3069 SYGI--FFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTE 2896
+ F + ++ G SAG+ T K + ++ A SIA QT+G +TV SL +++
Sbjct: 215 LVVLCMFPFIMVSMMGLGMSAGIF--TMKSHKPFSEACSIAEQTIGNIRTVHSLTQERSF 272
Query: 2895 IERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVG---------ATMIYSG 2743
E Y ++ +KY I++++ G FF S N + + G + + +G
Sbjct: 273 CESYNTKIMETDKYNIKKSIGIGTGLGCMMFFIMSSNALGSWYGNFVVRGKGGSDNVKAG 332
Query: 2742 TLETAVV-----------------------VRDDNVIEKDETDYDVE---------VEVN 2659
T+ T + V NV + + D++ E N
Sbjct: 333 TVLTVFMSVLLATQSLSQISTPINILNSAKVAAFNVYQTIDRIPDIDCQSIGGECPTECN 392
Query: 2658 GNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSG 2479
GNI F++V+F YPTR VLKG+ +++ G+ IALVGASG GKST +QL+ Y+ + G
Sbjct: 393 GNIRFEDVQFVYPTRLSHHVLKGLDLEIKKGQTIALVGASGCGKSTTIQLIQRNYDPNGG 452
Query: 2478 NIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLP---EIYGALRK 2308
+ +DG D+ ++NIK LR IG+V QEPVLF TI ENI G + P E+ +
Sbjct: 453 RVTLDGKDIRELNIKWLRNQIGLVGQEPVLFAGTIRENIMLGAKEGATPSEEEMIECAKM 512
Query: 2307 ANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESE 2128
ANA+DF+ P+G TI+GE+G LSGGQKQRIAIAR L+RNP ILLLDEATSALD +SE
Sbjct: 513 ANAHDFISKLPEGYDTIIGEKGALLSGGQKQRIAIARALIRNPSILLLDEATSALDTQSE 572
Query: 2127 QVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLV 1948
++VQ+ALE AS+GRTTI+VAHRL+T+RNA KI V +GEI+E G H EL+ +G Y LV
Sbjct: 573 KIVQEALEKASKGRTTIIVAHRLTTVRNADKICVFHQGEIIEQGKHQELMDLKGTYYGLV 632
Query: 1947 QAQLLESHDDHEELPPLAARQLSQELSPLHSYAIQRSTSNDAGVHDDDMERILDELSKEG 1768
+ Q +E D E + + QE + + +++++ ++ + +++I E +E
Sbjct: 633 KRQSMEEEVDQETVENDLKKFREQEDKEVENISLEQTNLHN---ENSIVKQIKQEYKEEQ 689
Query: 1767 AKKSN------LREIVKQCRPDYCFLFIAVFGSAIQGVSYPI-------LAQLIVRTYEG 1627
K + R I + +Y F + + G G ++P L +++++ + G
Sbjct: 690 KKLKHSNRFVLFRVIWNNYKHEYIFCTLGLIGGIGAGAAFPFYSLNFVDLIRVLMKLHPG 749
Query: 1626 FAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLP 1447
+ E + + + + ++ +C F E++ R+R + + ++
Sbjct: 750 INLTDEQANSILRS-CMIIICIGIITMISFFCYVGLFMAAGEKMIGRIRRRFYYSIMHQN 808
Query: 1446 CAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLE 1267
+++D + ++ +L +D ++++ +R+G +I + + + WK++L
Sbjct: 809 VSWFDRRENMVGAVTTKLTSDPTSLQGISAERVGDIIEIMSTVGFGFGIGLYFSWKLSLC 868
Query: 1266 VLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLI 1087
+L FP A+E T +E +E ++T ++L ED
Sbjct: 869 ILAVFPIISFFMFINGQLNSKNAAPAKAAYEQCGVTLVEVVEAMKTAQSLGKEDYFSQKY 928
Query: 1086 SEHLQKIHKSYFK----RAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAP----- 934
+ LQ + K +I N L+ S + Y + F ++ P
Sbjct: 929 NNDLQIPKRGIIKWGPLLSITNAITNLLTFSINAYGYYLGICFMKKTINYQQDVPNFVDE 988
Query: 933 -MDTYLVLMTLSMTANMAGSAAA----YLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGK 769
+DT+ + MT N A ++ A LPD KAV AA I+++ ++ S +G+
Sbjct: 989 IIDTFGDIQKALMTINSATTSFAQIGNVLPDVGKAVGAAKSIYNIIDRKPSIDCYSEEGE 1048
Query: 768 K-NIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERF 592
N KGEI +N+ F Y R D +L G++ K + GKT+ALVG SGCGKST I L+ERF
Sbjct: 1049 TFNDVKGEIEFKNIHFRYPTRADNEVLKGISFKAEQGKTIALVGASGCGKSTTIQLIERF 1108
Query: 591 YHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTR--SVPQLEL 418
Y GEV +D N++D+N++ LR+ + LV QEP LF S+ +N+ G+ V ++
Sbjct: 1109 YDPTSGEVLLDGHNIKDLNIHFLRNQIGLVGQEPVLFAESVIDNIKRGVPEGVEVSNEQI 1168
Query: 417 EKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSA 238
A + ANA +F+ P+G +T+VG+RG+QLSGGQKQRIAIARA++RNPKVLLLDEATSA
Sbjct: 1169 YAAAKMANAHDFISAMPEGYNTMVGDRGSQLSGGQKQRIAIARALIRNPKVLLLDEATSA 1228
Query: 237 LDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRS 58
LDS+SEK+VQ+ALD AS+ +T+V+AHRLST+ NAD I V+ GK+ EQG H+EL+ +
Sbjct: 1229 LDSESEKIVQDALDKASKGRTTIVIAHRLSTIQNADKIYVIMRGKIVEQGKHQELIDLKG 1288
Query: 57 IYWRLVQKQ 31
Y+ L +Q
Sbjct: 1289 FYYTLAMQQ 1297
Score = 276 bits (705), Expect = 3e-72
Identities = 188/615 (30%), Positives = 303/615 (48%), Gaps = 29/615 (4%)
Frame = -1
Query: 1761 KSNLREIVKQCRP-DYCFLFIAVFGSAIQGVSYPILAQL---IVRTY---EGFAMIG--- 1612
K N++E+ + + L I + GS G P+L L +V T+ E F+ G
Sbjct: 32 KVNIKELFRYAGVFEIILLIIGIIGSIGVGCLNPLLMILTGDVVDTFVNGENFSKEGGSI 91
Query: 1611 ----EDMLYYS--------HLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSF 1468
E+M Y + L ++ A+ + + Q F +SE ++R F
Sbjct: 92 KITTEEMNYEIMNSISDTINKLVLKMLYFAIGNMVAGFLQTICFFVLSEYQGIKIRSLYF 151
Query: 1467 SHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLY 1288
+L ++D H L++++ D ++ + + G + T + +
Sbjct: 152 KALLRQDPGWFDC--HKTGELTSKIINDIQKIQDGMSLKFGRLFQTFSSFITGYLIGFIK 209
Query: 1287 CWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLE 1108
CW +TL VL FP + F + A + + N+RTV +L E
Sbjct: 210 CWDLTLVVLCMFPFIMVSMMGLGMSAGIFTMKSHKPFSEACSIAEQTIGNIRTVHSLTQE 269
Query: 1107 DKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRK----EV 940
+ + + K K++I G G + + ++ +G ++ K V
Sbjct: 270 RSFCESYNTKIMETDKYNIKKSIGIGTGLGCMMFFIMSSNALGSWYGNFVVRGKGGSDNV 329
Query: 939 APMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNI 760
V M++ + + + A AA ++ + S G+
Sbjct: 330 KAGTVLTVFMSVLLATQSLSQISTPINILNSAKVAAFNVYQTIDRIPDIDCQSIGGECPT 389
Query: 759 E-KGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHA 583
E G I E+VQF Y R +L G++L++ G+T+ALVG SGCGKST I L++R Y
Sbjct: 390 ECNGNIRFEDVQFVYPTRLSHHVLKGLDLEIKKGQTIALVGASGCGKSTTIQLIQRNYDP 449
Query: 582 VDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELE--KA 409
G V +D +++ ++N+ LR+ + LV QEP LF +IREN++ G E E +
Sbjct: 450 NGGRVTLDGKDIRELNIKWLRNQIGLVGQEPVLFAGTIRENIMLGAKEGATPSEEEMIEC 509
Query: 408 LQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDS 229
+ ANA +F+ + P+G DT++GE+GA LSGGQKQRIAIARA++RNP +LLLDEATSALD+
Sbjct: 510 AKMANAHDFISKLPEGYDTIIGEKGALLSGGQKQRIAIARALIRNPSILLLDEATSALDT 569
Query: 228 DSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYW 49
SEK+VQ AL+ AS+ +T++VAHRL+TV NAD I V G++ EQG H+EL+ + Y+
Sbjct: 570 QSEKIVQEALEKASKGRTTIIVAHRLTTVRNADKICVFHQGEIIEQGKHQELMDLKGTYY 629
Query: 48 RLVQKQGIQVETPSD 4
LV++Q ++ E +
Sbjct: 630 GLVKRQSMEEEVDQE 644
>gi|26449438|dbj|BAC41846.1| putative P-glycoprotein [Arabidopsis
thaliana]
Length = 1252
Score = 646 bits (1666), Expect = 0.0
Identities = 414/1264 (32%), Positives = 644/1264 (50%), Gaps = 52/1264 (4%)
Frame = -1
Query: 3666 SNNFSTPLLPQSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTF 3487
+N +P EKK Q F ++ F + F+ L +G L +++ G P F
Sbjct: 4 TNTTDAKTVPAEAEKKKEQSLPFFKL-FSFADKFDYLLMFVGSLGAIVHGSSMPVFFLLF 62
Query: 3486 GEVSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIM 3307
G++ +N + DL + E R +F G + + A
Sbjct: 63 GQM----------VNGFGKNQMDLHQMVHEVSR----YSLYFVYLGLVVCFSSYAEIACW 108
Query: 3306 KYVGDNTTYRVRKQYISRLLKKDAQYFDS-VSTGHLSTVLNDNLERFREVFNEKIALIIA 3130
Y G+ +RK+Y+ +LK+D +FD+ TG + ++ + ++ +EK+ I
Sbjct: 109 MYSGERQVAALRKKYLEAVLKQDVGFFDTDARTGDIVFSVSTDTLLVQDAISEKVGNFIH 168
Query: 3129 FVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAF 2950
+++ F G + F + W+LA + GIAF+G + + + T K YANAG IA
Sbjct: 169 YLSTFLAGLVVGFVSAWKLALLSVAVIPGIAFAGGLYAYTLTGITSKSRESYANAGVIAE 228
Query: 2949 QTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTY-FFCNSLNTVVL 2773
Q + +TV S G+ + Y++ ++ K G + + + G TY C S V
Sbjct: 229 QAIAQVRTVYSYVGESKALNAYSDAIQYTLKLGYKAGMAKGLGLGCTYGIACMSWALVFW 288
Query: 2772 YVGA-------------TMIYSGTL-----------------------ETAVVVRDDNVI 2701
Y G T I+S + + ++ I
Sbjct: 289 YAGVFIRNGQTDGGKAFTAIFSAIVGGMSLGQSFSNLGAFSKGKAAGYKLMEIINQRPTI 348
Query: 2700 EKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKST 2521
+D D +V+GNI FK+V FSYP+RPD + + + +G+ +A+VG SGSGKST
Sbjct: 349 IQDPLDGKCLDQVHGNIEFKDVTFSYPSRPDVMIFRNFNIFFPSGKTVAVVGGSGSGKST 408
Query: 2520 VVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNV 2341
VV L+ +Y+ +SG I +DG+++ + +K LR IG+V+QEP LF TTI ENI +G P+
Sbjct: 409 VVSLIERFYDPNSGQILLDGVEIKTLQLKFLREQIGLVNQEPALFATTILENILYGKPDA 468
Query: 2340 SLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLD 2161
++ E+ A ANA+ F+ PKG T VGERG QLSGGQKQRIAIAR ++++PKILLLD
Sbjct: 469 TMVEVEAAASAANAHSFITLLPKGYDTQVGERGVQLSGGQKQRIAIARAMLKDPKILLLD 528
Query: 2160 EATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDEL 1981
EATSALD SE +VQ+AL+ GRTT+VVAHRL TIRN I V+Q+G++VE G H+EL
Sbjct: 529 EATSALDASSESIVQEALDRVMVGRTTVVVAHRLCTIRNVDSIAVIQQGQVVETGTHEEL 588
Query: 1980 IAKRGVYNDLVQAQLLESHDDHEE-----------LPPLAARQLSQELSPLHSYAIQRST 1834
IAK G Y L++ Q + D L+ + LS L + + ST
Sbjct: 589 IAKSGAYASLIRFQEMVGTRDFSNPSTRRTRSTRLSHSLSTKSLSLRSGSLRNLSYSYST 648
Query: 1833 SNDAGVHDDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILA 1654
D + +M + K A ++ ++K P++ + + GS + G P A
Sbjct: 649 GADGRI---EMISNAETDRKTRAPENYFYRLLKLNSPEWPYSIMGAVGSILSGFIGPTFA 705
Query: 1653 QLIVRTYEGFAMIGED-MLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRI 1477
++ E F D M + + ++ ++ Q+Y+F + E L+TR+R
Sbjct: 706 IVMSNMIEVFYYTDYDSMERKTKEYVFIYIGAGLYAVGAYLIQHYFFSIMGENLTTRVRR 765
Query: 1476 KSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTA 1297
S +L ++D+ H+++ ++ RL TD+++VK+A+ +R+ ++ + ++ + A
Sbjct: 766 MMLSAILRNEVGWFDEDEHNSSLIAARLATDAADVKSAIAERISVILQNMTSLLTSFIVA 825
Query: 1296 SLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRAL 1117
+ W+++L +L FP + A ++ A E + N+RTV A
Sbjct: 826 FIVEWRVSLLILGTFPLLVLANFAQQLSLKGFAGDTAKAHAKTSMIAGEGVSNIRTVAAF 885
Query: 1116 NLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVA 937
N + KI+SL L+ K R+ G GLS ++ +G +L +
Sbjct: 886 NAQSKILSLFCHELRVPQKRSLYRSQTSGFLFGLSQLALYGSEALILWYGAHLVSKGVST 945
Query: 936 PMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKK-NI 760
V + L +TAN + P+ + A G +F + + +D
Sbjct: 946 FSKVIKVFVVLVITANSVAETVSLAPEIIRGGEAVGSVFSVLDRQTRIDPDDADADPVET 1005
Query: 759 EKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAV 580
+G+I +V F Y RPD M+ NL++ G + ALVG SG GKS++I+++ERFY +
Sbjct: 1006 IRGDIEFRHVDFAYPSRPDVMVFRDFNLRIRAGHSQALVGASGSGKSSVIAMIERFYDPL 1065
Query: 579 DGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQT 400
G+V ID +++ +NL LR + LV QEP LF +I +N+ YG + E+ A +
Sbjct: 1066 AGKVMIDGKDIRRLNLKSLRLKIGLVQQEPALFAATIFDNIAYG-KDGATESEVIDAARA 1124
Query: 399 ANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSE 220
ANA F+ P+G T VGERG QLSGGQKQRIAIARA+L+NP VLLLDEATSALD++SE
Sbjct: 1125 ANAHGFISGLPEGYKTPVGERGVQLSGGQKQRIAIARAVLKNPTVLLLDEATSALDAESE 1184
Query: 219 KVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELL-RKRSIYWRL 43
V+Q AL+ +TVVVAHRLST+ D I V+++ ++ EQG+H EL+ R Y RL
Sbjct: 1185 CVLQEALERLMRGRTTVVVAHRLSTIRGVDCIGVIQDERIVEQGSHSELVSRPEGAYSRL 1244
Query: 42 VQKQ 31
+Q Q
Sbjct: 1245 LQLQ 1248
>gi|15147363|gb|AAG01549.3| multidrug resistance protein MDR
[Trichophyton rubrum]
Length = 1331
Score = 645 bits (1665), Expect = 0.0
Identities = 428/1252 (34%), Positives = 648/1252 (51%), Gaps = 80/1252 (6%)
Frame = -1
Query: 3537 LFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQVVFHFF 3358
L S+ G P + FG ++ I A++ T Y+E+ + + +F
Sbjct: 101 LASIAAGAALPLFTVLFGSLAGTFRDI--ALHRIT---------YDEFNSILTRNSLYFV 149
Query: 3357 LCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNL 3178
G A FI + YVG++ T ++R +Y+ +L+++ +FD + G ++T + +
Sbjct: 150 YLGIAQFILLYVSTVGFIYVGEHITQKIRAKYLHAILRQNIGFFDKLGAGEVTTRITADT 209
Query: 3177 ERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASY--GIFFSLGIAFSGFINSAGVM 3004
++ +EK+ L + ++ F + + W+LA ++ + G S V+
Sbjct: 210 NLIQDGISEKVGLTLTALSTFFSAFIIGYVRYWKLALICSSTIVAMILVMGGI--SRFVV 267
Query: 3003 KTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSI 2824
K+ Y G++A + + + + + Q+ +Y LK K+G R +M I
Sbjct: 268 KSGRMTLVSYGEGGTVAEEVISSIRNATAFGTQEKLARQYEVHLKEARKWGRRLQMMLGI 327
Query: 2823 SRGVTYFFCNSLNTVVLYVGATMIYSGTLETAVVVRD----------------------- 2713
G S + ++G+ + G + + +V
Sbjct: 328 MFGSMMAIMYSNYGLGFWMGSRFLVGGETDLSAIVNILLAIVIGSFSIGNVAPNTQAFAS 387
Query: 2712 ------------DNV--IEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDV 2575
D V I+ + D V G I F+ +K YP+RP+ V++ I+ V
Sbjct: 388 AISAGAKIFSTIDRVSAIDPGSDEGDTIENVEGTIEFRGIKHIYPSRPEVVVMEDINLVV 447
Query: 2574 QNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEP 2395
G+ ALVG SGSGKSTVV LL +YN SG++ +DG D+ +N++ LR+ I +VSQEP
Sbjct: 448 PKGKTTALVGPSGSGKSTVVGLLERFYNPVSGSVLLDGRDIKTLNLRWLRQQISLVSQEP 507
Query: 2394 VLFNTTIEENIRFG---NPNVSLPE------IYGALRKANAYDFVCSFPKGIKTIVGERG 2242
LF TTI ENIR G +P + E I A ++ANA+DF+ P G T VG+RG
Sbjct: 508 TLFGTTIFENIRLGLIGSPMENESEEQIKERIVSAAKEANAHDFIMGLPDGYATDVGQRG 567
Query: 2241 TQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHR 2062
LSGGQKQRIAIAR +V +PKILLLDEATSALD +SE VVQ AL+ AS+GRTTIV+AHR
Sbjct: 568 FLLSGGQKQRIAIARAIVSDPKILLLDEATSALDTKSEGVVQAALDAASRGRTTIVIAHR 627
Query: 2061 LSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLESHDDHEELPPLAARQL 1882
LSTI++A I+V+ G I E G HDEL+ K+G Y LV+AQ + + + EE A +
Sbjct: 628 LSTIKSADNIVVIVGGRIAEQGTHDELVDKKGTYLQLVEAQKI-NEERGEESEDEAVLEK 686
Query: 1881 SQELSPLHSYAIQRSTSNDAGVHDDDMERILDELSKEGAKKSNLREIVKQCRPD------ 1720
+E+S ++ + N D+D+E L + KKS I+ Q R
Sbjct: 687 EKEIS--RQISVPAKSVNSGKYPDEDVEA---NLGRIDTKKSLSSVILSQKRSQEKETEY 741
Query: 1719 --------------------YCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDML 1600
C F AV A Q V A+ I ++ G+ +
Sbjct: 742 SLGTLIRFIAGFNKPERLIMLCGFFFAVLSGAGQPVQSVFFAKGITTLSLPPSLYGK-LR 800
Query: 1599 YYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNH 1420
++ W+L F+ L + + +T Q F SE L R R KSF ML AF+D P +
Sbjct: 801 EDANFWSLMFLMLGLVQLVTQSAQGVIFAICSESLIYRARSKSFRAMLRQDIAFFDLPEN 860
Query: 1419 SATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXX 1240
S L++ L+T++ ++ LG ++M + +A+T A + WK+ L + P
Sbjct: 861 STGALTSFLSTETKHLSGVSGATLGTILMVSTTLIVALTVALAFGWKLALVCISTVPVLL 920
Query: 1239 XXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSL----ISEHLQ 1072
A+E+S A EA ++RTV +L E +M + +++ +
Sbjct: 921 LCGFYRFWILAQFQTRAKKAYESSASYACEATSSIRTVASLTREQGVMEIYEGQLNDQAK 980
Query: 1071 KIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTA 892
K +S K +++ A+ S C ++ F +G L + E +L + + +
Sbjct: 981 KSLRSVAKSSLLYAASQSFSFFCL----ALGFWYGGGLLGKGEYNAFQFFLCISCVIFGS 1036
Query: 891 NMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKK-NIEKGEIIGENVQFHYD 715
AG ++ PD KA AA LF T+ S+DG+K +G I +V F Y
Sbjct: 1037 QSAGIVFSFSPDMGKAKSAAADFKRLFDRVPTIDIESTDGEKLETVEGTIEFRDVHFRYP 1096
Query: 714 QRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDIN 535
RP++ +L G+NL V PG+ +ALVGPSGCGKST I+L+ERFY + G V ID +++ +N
Sbjct: 1097 TRPEQPVLRGLNLTVKPGQYIALVGPSGCGKSTTIALVERFYDTLSGGVYIDGKDISRLN 1156
Query: 534 LNHLRSNLALVSQEPTLFNCSIRENLLYGLTR-SVPQLELEKALQTANAFNFVFQFPQGL 358
+N RS+LALVSQEPTL+ +IR+N+L G+ R VP ++ A + AN ++F+ P G
Sbjct: 1157 VNSYRSHLALVSQEPTLYQGTIRDNVLLGVDRDDVPDEQVFAACKAANIYDFIMSLPDGF 1216
Query: 357 DTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERL 178
T+VG +G+ LSGGQKQRIAIARA++R+PKVLLLDEATSALDS+SEKVVQ ALD A++
Sbjct: 1217 GTVVGSKGSMLSGGQKQRIAIARALIRDPKVLLLDEATSALDSESEKVVQAALDAAAKGR 1276
Query: 177 STVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQ 22
+T+ VAHRLST+ AD I V G++ E GTH ELL+ + Y+ LV Q ++
Sbjct: 1277 TTIAVAHRLSTIQKADIIYVFDQGRIVESGTHHELLQNKGRYYELVHMQSLE 1328
Score = 300 bits (767), Expect = 2e-79
Identities = 196/587 (33%), Positives = 299/587 (50%), Gaps = 42/587 (7%)
Frame = -1
Query: 3564 EKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEKAYEEYERG 3385
E+ + L G F++++G QP S F + I ++ P+ Y +
Sbjct: 757 ERLIMLCGFFFAVLSGAGQPVQSVFFAK----------GITTLSLPPS----LYGKLRED 802
Query: 3384 MNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQYFD--SVST 3211
N F + G + S Q I ++ YR R + +L++D +FD ST
Sbjct: 803 ANFWSLMFLMLGLVQLVTQSAQGVIFAICSESLIYRARSKSFRAMLRQDIAFFDLPENST 862
Query: 3210 GHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFS 3031
G L++ L+ + V + I+ T + +A W+LA I +
Sbjct: 863 GALTSFLSTETKHLSGVSGATLGTILMVSTTLIVALTVALAFGWKLALVCISTVPVLLLC 922
Query: 3030 GFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYG 2851
GF + + + Y ++ S A + + +TV SL ++ +E Y +L K
Sbjct: 923 GFYRFWILAQFQTRAKKAYESSASYACEATSSIRTVASLTREQGVMEIYEGQLNDQAKKS 982
Query: 2850 IR----RALMYSISRGVTYFFCNSL--------------NTVVLYVGATMIYSGTLETAV 2725
+R +L+Y+ S+ + FFC +L N ++ + + G+ +
Sbjct: 983 LRSVAKSSLLYAASQSFS-FFCLALGFWYGGGLLGKGEYNAFQFFLCISCVIFGSQSAGI 1041
Query: 2724 VVR------------------DDNV--IEKDETDYDVEVEVNGNISFKNVKFSYPTRPDA 2605
V D V I+ + TD + V G I F++V F YPTRP+
Sbjct: 1042 VFSFSPDMGKAKSAAADFKRLFDRVPTIDIESTDGEKLETVEGTIEFRDVHFRYPTRPEQ 1101
Query: 2604 QVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLR 2425
VL+G++ V+ G+ IALVG SG GKST + L+ +Y+ SG ++IDG D++ +N+ R
Sbjct: 1102 PVLRGLNLTVKPGQYIALVGPSGCGKSTTIALVERFYDTLSGGVYIDGKDISRLNVNSYR 1161
Query: 2424 RVIGVVSQEPVLFNTTIEENIRFGNPNVSLP--EIYGALRKANAYDFVCSFPKGIKTIVG 2251
+ +VSQEP L+ TI +N+ G +P +++ A + AN YDF+ S P G T+VG
Sbjct: 1162 SHLALVSQEPTLYQGTIRDNVLLGVDRDDVPDEQVFAACKAANIYDFIMSLPDGFGTVVG 1221
Query: 2250 ERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVV 2071
+G+ LSGGQKQRIAIAR L+R+PK+LLLDEATSALD+ESE+VVQ AL+ A++GRTTI V
Sbjct: 1222 SKGSMLSGGQKQRIAIARALIRDPKVLLLDEATSALDSESEKVVQAALDAAAKGRTTIAV 1281
Query: 2070 AHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLE 1930
AHRLSTI+ A I V +G IVE G H EL+ +G Y +LV Q LE
Sbjct: 1282 AHRLSTIQKADIIYVFDQGRIVESGTHHELLQNKGRYYELVHMQSLE 1328
Score = 289 bits (739), Expect = 4e-76
Identities = 189/587 (32%), Positives = 296/587 (50%), Gaps = 16/587 (2%)
Frame = -1
Query: 1728 RPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYYSHLWA------LSFM 1567
R D FL I S G + P+ L F I + Y + L F+
Sbjct: 90 RNDMIFLAIVSLASIAAGAALPLFTVLFGSLAGTFRDIALHRITYDEFNSILTRNSLYFV 149
Query: 1566 FLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNT 1387
+L + + + LY F V E ++ ++R K +L F+D A ++ R+
Sbjct: 150 YLGIAQFILLYVSTVGFIYVGEHITQKIRAKYLHAILRQNIGFFD--KLGAGEVTTRITA 207
Query: 1386 DSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXX 1207
D++ ++ + +++G + + A + WK+ L
Sbjct: 208 DTNLIQDGISEKVGLTLTALSTFFSAFIIGYVRYWKLALICSSTIVAMILVMGGISRFVV 267
Query: 1206 XAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGA 1027
+ + +++ A E + ++R A ++K+ HL++ K + ++ G
Sbjct: 268 KSGRMTLVSYGEGGTVAEEVISSIRNATAFGTQEKLARQYEVHLKEARKWGRRLQMMLGI 327
Query: 1026 ANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKK 847
G ++ Y + F G+ + E +L+ + + + G+ A +
Sbjct: 328 MFGSMMAIMYSNYGLGFWMGSRFLVGGETDLSAIVNILLAIVIGSFSIGNVAPNTQAFAS 387
Query: 846 AVHAAGLIFHLFTYPATMPFSSSDGK--KNIEKGEIIGENVQFHYDQRPDRMILNGVNLK 673
A+ A IF + + S +G +N+E G I ++ Y RP+ +++ +NL
Sbjct: 388 AISAGAKIFSTIDRVSAIDPGSDEGDTIENVE-GTIEFRGIKHIYPSRPEVVVMEDINLV 446
Query: 672 VDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQE 493
V GKT ALVGPSG GKST++ LLERFY+ V G V +D +++ +NL LR ++LVSQE
Sbjct: 447 VPKGKTTALVGPSGSGKSTVVGLLERFYNPVSGSVLLDGRDIKTLNLRWLRQQISLVSQE 506
Query: 492 PTLFNCSIRENLLYGLTRSVPQLELEK--------ALQTANAFNFVFQFPQGLDTLVGER 337
PTLF +I EN+ GL S + E E+ A + ANA +F+ P G T VG+R
Sbjct: 507 PTLFGTTIFENIRLGLIGSPMENESEEQIKERIVSAAKEANAHDFIMGLPDGYATDVGQR 566
Query: 336 GAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAH 157
G LSGGQKQRIAIARAI+ +PK+LLLDEATSALD+ SE VVQ ALD AS +T+V+AH
Sbjct: 567 GFLLSGGQKQRIAIARAIVSDPKILLLDEATSALDTKSEGVVQAALDAASRGRTTIVIAH 626
Query: 156 RLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQVE 16
RLST+ +AD+I V+ G++AEQGTH+EL+ K+ Y +LV+ Q I E
Sbjct: 627 RLSTIKSADNIVVIVGGRIAEQGTHDELVDKKGTYLQLVEAQKINEE 673
>gi|15229473|ref|NP_189475.1| ABC transporter family protein
[Arabidopsis thaliana]
Length = 1240
Score = 645 bits (1664), Expect = 0.0
Identities = 411/1233 (33%), Positives = 659/1233 (53%), Gaps = 44/1233 (3%)
Frame = -1
Query: 3597 IRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPAD 3418
+R +F + + L LG++ ++ GF P VL+ + +NN +
Sbjct: 20 VRSIFMHADGVDWLLMGLGLIGAVGDGFTTPL----------VLLITSKLMNNIGGSSFN 69
Query: 3417 LEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKD 3238
+ + + N V + CG ++ L+ G+ T R+R++Y+ +L++D
Sbjct: 70 TDTFMQSISK--NSVALLYVACGS--WVVCFLEGYCWTRTGERQTARMREKYLRAVLRQD 125
Query: 3237 AQYFDS--VSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASY 3064
YFD ST + T ++ + ++V +EK+ + + F + F WRLA
Sbjct: 126 VGYFDLHVTSTSDVITSVSSDSFVIQDVLSEKLPNFLMSASTFVGSYIVGFILLWRLAIV 185
Query: 3063 GIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERY 2884
G+ F + + G + ++ + K Y AG +A Q + + +TV + +G++ I ++
Sbjct: 186 GLPFIVLLVIPGLMYGRALISISRKIREEYNEAGFVAEQAISSVRTVYAFSGERKTISKF 245
Query: 2883 TEELKAGEKYGIRRALMYSI---SRGVTYFFCNSLN----TVVLYVGAT--MIYSGTLET 2731
+ L+ K GI++ L I S G+T+ ++ +V+Y GA +++
Sbjct: 246 STALQGSVKLGIKQGLAKGITIGSNGITFAMWGFMSWYGSRMVMYHGAQGGTVFAVAAAI 305
Query: 2730 AV---------------------------VVRDDNVIEKDETDYDVEVEVNGNISFKNVK 2632
A+ V+ I+ D D ++ G + FKNVK
Sbjct: 306 AIGGVSLGGGLSNLKYFFEAASVGERIMEVINRVPKIDSDNPDGHKLEKIRGEVEFKNVK 365
Query: 2631 FSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDL 2452
F YP+R + + V +G+ +ALVG SGSGKSTV+ LL +Y+ +G I IDG+ +
Sbjct: 366 FVYPSRLETSIFDDFCLRVPSGKTVALVGGSGSGKSTVISLLQRFYDPLAGEILIDGVSI 425
Query: 2451 NDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPK 2272
+ + +K LR +G+VSQEP LF TTI+ENI FG + S+ ++ A + +NA++F+ P
Sbjct: 426 DKLQVKWLRSQMGLVSQEPALFATTIKENILFGKEDASMDDVVEAAKASNAHNFISQLPN 485
Query: 2271 GIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQ 2092
G +T VGERG Q+SGGQKQRIAIAR ++++P ILLLDEATSALD+ESE+VVQ+ALENAS
Sbjct: 486 GYETQVGERGVQMSGGQKQRIAIARAIIKSPTILLLDEATSALDSESERVVQEALENASI 545
Query: 2091 GRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAK-RGVYNDLVQAQLLESHDDH 1915
GRTTI++AHRLSTIRNA I V++ G IVE G+HDEL+ G Y+ LV Q +E D +
Sbjct: 546 GRTTILIAHRLSTIRNADVISVVKNGHIVETGSHDELMENIDGQYSTLVHLQQIEKQDIN 605
Query: 1914 EELPPLAARQLSQELSPLHSYAIQRSTSNDAGVHDDDMERILDELSKEGAKKSNLREIVK 1735
+ S+++ + +S+ V + L E +K + + + ++
Sbjct: 606 VSVKIGPISDPSKDIRNSSRVSTLSRSSSANSVTGPSTIKNLSEDNK--PQLPSFKRLLA 663
Query: 1734 QCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDML-YYSHLWALSFMFLA 1558
P++ + + G P A + + + D + + ++ALSF+ LA
Sbjct: 664 MNLPEWKQALYGCISATLFGAIQPAYAYSLGSMVSVYFLTSHDEIKEKTRIYALSFVGLA 723
Query: 1557 VFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSS 1378
V L Q+Y F + E L+ R+R + S +L+ ++D +S+ + +RL D++
Sbjct: 724 VLSFLINISQHYNFAYMGEYLTKRIRERMLSKVLTFEVGWFDRDENSSGAICSRLAKDAN 783
Query: 1377 NVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAI 1198
V++ V DR+ V+ TV A++IA T + W++ L ++ P
Sbjct: 784 VVRSLVGDRMALVVQTVSAVTIAFTMGLVIAWRLALVMIAVQPVIIVCFYTRRVLLKSMS 843
Query: 1197 QEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANG 1018
++ A + S++ A EA+ NVRT+ A + +++IM ++ + + + +++ G
Sbjct: 844 KKAIKAQDESSKLAAEAVSNVRTITAFSSQERIMKMLEKAQESPRRESIRQSWFAGFGLA 903
Query: 1017 LSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVH 838
+S S +++ F +G L + + M L T + A + D K
Sbjct: 904 MSQSLTSCTWALDFWYGGRLIQDGYITAKALFETFMILVSTGRVIADAGSMTTDLAKGSD 963
Query: 837 AAGLIFHLFTYPATMPFSSSDGKKNIE-KGEIIGENVQFHYDQRPDRMILNGVNLKVDPG 661
A G +F + ++ DG + G++ +V F Y RPD +I ++K++ G
Sbjct: 964 AVGSVFAVLDRYTSIDPEDPDGYETERITGQVEFLDVDFSYPTRPDVIIFKNFSIKIEEG 1023
Query: 660 KTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLF 481
K+ A+VGPSG GKSTII L+ERFY + G VKID ++ +L LR ++ALVSQEPTLF
Sbjct: 1024 KSTAIVGPSGSGKSTIIGLIERFYDPLKGIVKIDGRDIRSYHLRSLRRHIALVSQEPTLF 1083
Query: 480 NCSIRENLLY-GLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQR 304
+IREN++Y G++ + + E+ +A + ANA +F+ +G DT G+RG QLSGGQKQR
Sbjct: 1084 AGTIRENIIYGGVSDKIDEAEIIEAAKAANAHDFITSLTEGYDTYCGDRGVQLSGGQKQR 1143
Query: 303 IAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSI 124
IAIARA+L+NP VLLLDEATSALDS SE+VVQ+AL+ ++VV+AHRLST+ N D+I
Sbjct: 1144 IAIARAVLKNPSVLLLDEATSALDSQSERVVQDALERVMVGRTSVVIAHRLSTIQNCDAI 1203
Query: 123 AVLKNGKVAEQGTHEELLRK--RSIYWRLVQKQ 31
AVL GK+ E+GTH LL K IY+ LV Q
Sbjct: 1204 AVLDKGKLVERGTHSSLLSKGPTGIYFSLVSLQ 1236
Score = 272 bits (695), Expect = 5e-71
Identities = 193/614 (31%), Positives = 308/614 (49%), Gaps = 49/614 (7%)
Frame = -1
Query: 3633 SDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGE-VSQVLVTI 3457
S++ KP Q+ SF R++ +++ L+ G + + + G QP +Y+ G VS +T
Sbjct: 648 SEDNKP-QLPSFKRLLAMNLPEWKQALY--GCISATLFGAIQPAYAYSLGSMVSVYFLTS 704
Query: 3456 TNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYR 3277
+ I KT + Y F F+ QH Y+G+ T R
Sbjct: 705 HDEIKEKT-------RIY----------ALSFVGLAVLSFLINISQHYNFAYMGEYLTKR 747
Query: 3276 VRKQYISRLLKKDAQYF--DSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGT 3103
+R++ +S++L + +F D S+G + + L + R + +++AL++ V+ T+
Sbjct: 748 IRERMLSKVLTFEVGWFDRDENSSGAICSRLAKDANVVRSLVGDRMALVVQTVSAVTIAF 807
Query: 3102 ALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTV 2923
+ WRLA I I + + + K + +A + + +T+
Sbjct: 808 TMGLVIAWRLALVMIAVQPVIIVCFYTRRVLLKSMSKKAIKAQDESSKLAAEAVSNVRTI 867
Query: 2922 CSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNT------------- 2782
+ + Q ER + L+ ++ R ++ S G SL +
Sbjct: 868 TAFSSQ----ERIMKMLEKAQESPRRESIRQSWFAGFGLAMSQSLTSCTWALDFWYGGRL 923
Query: 2781 ----------------VVLYVGATMIYSGTLET-------------AVVVRDDNVIEKDE 2689
+++ G + +G++ T AV+ R ++ +D
Sbjct: 924 IQDGYITAKALFETFMILVSTGRVIADAGSMTTDLAKGSDAVGSVFAVLDRYTSIDPEDP 983
Query: 2688 TDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQL 2509
Y+ E + G + F +V FSYPTRPD + K S ++ G+ A+VG SGSGKST++ L
Sbjct: 984 DGYETE-RITGQVEFLDVDFSYPTRPDVIIFKNFSIKIEEGKSTAIVGPSGSGKSTIIGL 1042
Query: 2508 LLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFG--NPNVSL 2335
+ +Y+ G + IDG D+ +++ LRR I +VSQEP LF TI ENI +G + +
Sbjct: 1043 IERFYDPLKGIVKIDGRDIRSYHLRSLRRHIALVSQEPTLFAGTIRENIIYGGVSDKIDE 1102
Query: 2334 PEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEA 2155
EI A + ANA+DF+ S +G T G+RG QLSGGQKQRIAIAR +++NP +LLLDEA
Sbjct: 1103 AEIIEAAKAANAHDFITSLTEGYDTYCGDRGVQLSGGQKQRIAIARAVLKNPSVLLLDEA 1162
Query: 2154 TSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIA 1975
TSALD++SE+VVQ ALE GRT++V+AHRLSTI+N I V+ KG++VE G H L++
Sbjct: 1163 TSALDSQSERVVQDALERVMVGRTSVVIAHRLSTIQNCDAIAVLDKGKLVERGTHSSLLS 1222
Query: 1974 K--RGVYNDLVQAQ 1939
K G+Y LV Q
Sbjct: 1223 KGPTGIYFSLVSLQ 1236
Score = 268 bits (685), Expect = 7e-70
Identities = 176/582 (30%), Positives = 309/582 (52%), Gaps = 14/582 (2%)
Frame = -1
Query: 1722 DYCFLFIAVFGSAIQGVSYPILAQL---IVRTYEGFAMIGEDMLYYSHLWALSFMFLAVF 1552
D+ + + + G+ G + P++ + ++ G + + + +++ +++A
Sbjct: 31 DWLLMGLGLIGAVGDGFTTPLVLLITSKLMNNIGGSSFNTDTFMQSISKNSVALLYVACG 90
Query: 1551 RPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNV 1372
+ + + Y + + E+ + R+R K +L ++D S + + +++DS +
Sbjct: 91 SWVVCFLEGYCWTRTGERQTARMREKYLRAVLRQDVGYFDLHVTSTSDVITSVSSDSFVI 150
Query: 1371 KAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQE 1192
+ + ++L +M+ + + W++ + L F ++
Sbjct: 151 QDVLSEKLPNFLMSASTFVGSYIVGFILLWRLAIVGLPFIVLLVIPGLMYGRALISISRK 210
Query: 1191 DTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQG---AAN 1021
+ + A +A+ +VRTV A + E K +S S LQ K K+ + +G +N
Sbjct: 211 IREEYNEAGFVAEQAISSVRTVYAFSGERKTISKFSTALQGSVKLGIKQGLAKGITIGSN 270
Query: 1020 GLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAV 841
G++ + + F+ +G+ + + + V +++ G + L + +A
Sbjct: 271 GITFAMWGFM----SWYGSRMVMYHGAQGGTVFAVAAAIAIGGVSLGGGLSNLKYFFEAA 326
Query: 840 HAAGLIFHLFTYPATMPFSSSDGKKNIEK--GEIIGENVQFHYDQRPDRMILNGVNLKVD 667
I + + + DG K +EK GE+ +NV+F Y R + I + L+V
Sbjct: 327 SVGERIMEVINRVPKIDSDNPDGHK-LEKIRGEVEFKNVKFVYPSRLETSIFDDFCLRVP 385
Query: 666 PGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPT 487
GKT+ALVG SG GKST+ISLL+RFY + GE+ ID +++ + + LRS + LVSQEP
Sbjct: 386 SGKTVALVGGSGSGKSTVISLLQRFYDPLAGEILIDGVSIDKLQVKWLRSQMGLVSQEPA 445
Query: 486 LFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQ 307
LF +I+EN+L+G ++ +A + +NA NF+ Q P G +T VGERG Q+SGGQKQ
Sbjct: 446 LFATTIKENILFG-KEDASMDDVVEAAKASNAHNFISQLPNGYETQVGERGVQMSGGQKQ 504
Query: 306 RIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADS 127
RIAIARAI+++P +LLLDEATSALDS+SE+VVQ AL+ AS +T+++AHRLST+ NAD
Sbjct: 505 RIAIARAIIKSPTILLLDEATSALDSESERVVQEALENASIGRTTILIAHRLSTIRNADV 564
Query: 126 IAVLKNGKVAEQGTHEELLR------KRSIYWRLVQKQGIQV 19
I+V+KNG + E G+H+EL+ ++ + ++KQ I V
Sbjct: 565 ISVVKNGHIVETGSHDELMENIDGQYSTLVHLQQIEKQDINV 606
>gi|15226477|ref|NP_182223.1| multidrug resistant (MDR) ABC
transporter, putative [Arabidopsis thaliana]
gi|7442647|pir||T02187 probable ABC transporter [imported] -
Arabidopsis thaliana
gi|3522943|gb|AAC34225.1| putative ABC transporter [Arabidopsis
thaliana]
Length = 1286
Score = 645 bits (1663), Expect = 0.0
Identities = 415/1263 (32%), Positives = 644/1263 (50%), Gaps = 63/1263 (4%)
Frame = -1
Query: 3636 QSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTI 3457
+ +E + ++ F ++ F + F+ L +LG L S+ G P M+ FG+ +
Sbjct: 36 KDEEHEKTKTVPFYKL-FAFADSFDFLLMILGTLGSIGNGLGFPLMTLLFGD-------L 87
Query: 3456 TNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYR 3277
+A + D +++V F G F A LQ + G+ R
Sbjct: 88 IDAFGENQTNTTDK----------VSKVALKFVWLGIGTFAAAFLQLSGWMISGERQAAR 137
Query: 3276 VRKQYISRLLKKDAQYFD-SVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTA 3100
+R Y+ +L++D +FD +TG + ++ + ++ EK+ I + F G
Sbjct: 138 IRSLYLKTILRQDIAFFDIDTNTGEVVGRMSGDTVLIQDAMGEKVGKAIQLLATFVGGFV 197
Query: 3099 LAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVC 2920
+AF W L + + +G + + + KT + T YA A ++ QT+G+ +TV
Sbjct: 198 IAFVRGWLLTLVMLSSIPLLVMAGALLAIVIAKTASRGQTAYAKAATVVEQTIGSIRTVA 257
Query: 2919 SLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMI---- 2752
S G+K I Y + L K G+ + G + + ++ G +I
Sbjct: 258 SFTGEKQAISNYNKHLVTAYKAGVIEGGSTGLGLGTLFLVVFCSYALAVWYGGKLILDKG 317
Query: 2751 YSG--TLETAVVVRDDNV-------------------------------IEKDETDYDVE 2671
Y+G L + V ++ I+ T+ V
Sbjct: 318 YTGGQVLNIIIAVLTGSMSLGQTSPCLSAFAAGQAAAYKMFETIERRPNIDSYSTNGKVL 377
Query: 2670 VEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYN 2491
++ G+I K+V F+YP RPD Q+ +G S + +G +ALVG SGSGKSTVV L+ +Y+
Sbjct: 378 DDIKGDIELKDVYFTYPARPDEQIFRGFSLFISSGTTVALVGQSGSGKSTVVSLIERFYD 437
Query: 2490 IDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALR 2311
+G++ IDG++L + +K +R IG+VSQEPVLF +I++NI +G + + EI A
Sbjct: 438 PQAGDVLIDGINLKEFQLKWIRSKIGLVSQEPVLFTASIKDNIAYGKEDATTEEIKAAAE 497
Query: 2310 KANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNES 2131
ANA FV P+G+ T+VGE GTQLSGGQKQRIA+AR ++++P+ILLLDEATSALD ES
Sbjct: 498 LANASKFVDKLPQGLDTMVGEHGTQLSGGQKQRIAVARAILKDPRILLLDEATSALDAES 557
Query: 2130 EQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIA-KRGVYND 1954
E+VVQ+AL+ RTT+VVAHRLST+RNA I V+ +G+IVE G+H EL+ G Y+
Sbjct: 558 ERVVQEALDRIMVNRTTVVVAHRLSTVRNADMIAVIHQGKIVEKGSHTELLKDPEGAYSQ 617
Query: 1953 LVQAQLLESHDDHEELPPLAARQLSQELSPLHSYAIQRSTSN------------------ 1828
L++ Q + D++ + S + S L ++ RS S
Sbjct: 618 LIRLQEEKKSDENAAEEQKMSSIESFKQSSLRKSSLGRSLSKGGSSRGNSSRHSFNMFGF 677
Query: 1827 DAGVHDD---DMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPIL 1657
AG+ + D E K KK ++ I +P+ L + +A GV PI
Sbjct: 678 PAGIDGNVVQDQEEDDTTQPKTEPKKVSIFRIAALNKPEIPVLILGSISAAANGVILPIF 737
Query: 1656 AQLIVRTYEGFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRI 1477
LI + F + + + WA+ FM L + Q ++F +L R+R
Sbjct: 738 GILISSVIKAFFQPPKKLKEDTSFWAIIFMVLGFASIIAYPAQTFFFAIAGCKLVQRIRS 797
Query: 1476 KSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTA 1297
F ++ + ++D+P +S+ + RL+ D++ ++ V D L + + +I + A
Sbjct: 798 MCFEKVVHMEVGWFDEPENSSGTIGARLSADAATIRGLVGDSLAQTVQNLSSILAGLIIA 857
Query: 1296 SLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRAL 1117
L CW++ VL P + + +++ A +A+ ++RTV +
Sbjct: 858 FLACWQLAFVVLAMLPLIALNGFLYMKFMKGFSADAKKMYGEASQVANDAVGSIRTVASF 917
Query: 1116 NLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVA 937
EDK+M++ S+ + K+ ++ I+ G G S Y+ SF G L +
Sbjct: 918 CAEDKVMNMYSKKCEGPMKNGIRQGIVSGIGFGFSFFVLFSSYAASFYVGARLVDDGKTT 977
Query: 936 PMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGK--KN 763
+ V L+M A +++ PD KA AA IF + + + S G+ N
Sbjct: 978 FDSVFRVFFALTMAAMAISQSSSLSPDSSKADVAAASIFAIMDRESKIDPSVESGRVLDN 1037
Query: 762 IEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHA 583
+ KG+I +V F Y RPD I + L + GKT+ALVG SG GKST+I+LL+RFY
Sbjct: 1038 V-KGDIELRHVSFKYPARPDVQIFQDLCLSIRAGKTVALVGESGSGKSTVIALLQRFYDP 1096
Query: 582 VDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQ 403
GE+ +D ++ + L LR LVSQEP LFN +IR N+ YG + E+ + +
Sbjct: 1097 DSGEITLDGVEIKSLRLKWLRQQTGLVSQEPILFNETIRANIAYGKGGDASESEIVSSAE 1156
Query: 402 TANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDS 223
+NA F+ QG DT+VGERG QLSGGQKQR+AIARAI+++PKVLLLDEATSALD++S
Sbjct: 1157 LSNAHGFISGLQQGYDTMVGERGIQLSGGQKQRVAIARAIVKDPKVLLLDEATSALDAES 1216
Query: 222 EKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLR-KRSIYWR 46
E+VVQ+ALD +T+VVAHRLST+ NAD IAV+KNG + E+G H+ L+ K +Y
Sbjct: 1217 ERVVQDALDRVMVNRTTIVVAHRLSTIKNADVIAVVKNGVIVEKGKHDTLINIKDGVYAS 1276
Query: 45 LVQ 37
LVQ
Sbjct: 1277 LVQ 1279
Score = 295 bits (754), Expect = 7e-78
Identities = 193/579 (33%), Positives = 303/579 (51%), Gaps = 6/579 (1%)
Frame = -1
Query: 1722 DYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYYSHLWALSFMFLAVFRPL 1543
D+ + + GS G+ +P++ L + F + AL F++L +
Sbjct: 59 DFLLMILGTLGSIGNGLGFPLMTLLFGDLIDAFGENQTNTTDKVSKVALKFVWLGIGTFA 118
Query: 1542 TLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAA 1363
+ Q + E+ + R+R +L AF+D ++ + R++ D+ ++ A
Sbjct: 119 AAFLQLSGWMISGERQAARIRSLYLKTILRQDIAFFDIDTNTG-EVVGRMSGDTVLIQDA 177
Query: 1362 VDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTI 1183
+ +++G I + A + W +TL +L P
Sbjct: 178 MGEKVGKAIQLLATFVGGFVIAFVRGWLLTLVMLSSIPLLVMAGALLAIVIAKTASRGQT 237
Query: 1182 AFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSC 1003
A+ + + + ++RTV + E + +S ++HL + +K +I+G + GL L
Sbjct: 238 AYAKAATVVEQTIGSIRTVASFTGEKQAISNYNKHL----VTAYKAGVIEGGSTGLGLGT 293
Query: 1002 FLFV----YSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHA 835
V Y+++ +G L L K +++ + + G + L + A
Sbjct: 294 LFLVVFCSYALAVWYGGKLILDKGYTGGQVLNIIIAVLTGSMSLGQTSPCLSAFAAGQAA 353
Query: 834 AGLIFHLFTYPATMPFSSSDGKKNIE-KGEIIGENVQFHYDQRPDRMILNGVNLKVDPGK 658
A +F + S++GK + KG+I ++V F Y RPD I G +L + G
Sbjct: 354 AYKMFETIERRPNIDSYSTNGKVLDDIKGDIELKDVYFTYPARPDEQIFRGFSLFISSGT 413
Query: 657 TLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFN 478
T+ALVG SG GKST++SL+ERFY G+V ID N+++ L +RS + LVSQEP LF
Sbjct: 414 TVALVGQSGSGKSTVVSLIERFYDPQAGDVLIDGINLKEFQLKWIRSKIGLVSQEPVLFT 473
Query: 477 CSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIA 298
SI++N+ YG + + E++ A + ANA FV + PQGLDT+VGE G QLSGGQKQRIA
Sbjct: 474 ASIKDNIAYGKEDATTE-EIKAAAELANASKFVDKLPQGLDTMVGEHGTQLSGGQKQRIA 532
Query: 297 IARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAV 118
+ARAIL++P++LLLDEATSALD++SE+VVQ ALD +TVVVAHRLSTV NAD IAV
Sbjct: 533 VARAILKDPRILLLDEATSALDAESERVVQEALDRIMVNRTTVVVAHRLSTVRNADMIAV 592
Query: 117 LKNGKVAEQGTHEELLR-KRSIYWRLVQKQGIQVETPSD 4
+ GK+ E+G+H ELL+ Y +L++ +Q E SD
Sbjct: 593 IHQGKIVEKGSHTELLKDPEGAYSQLIR---LQEEKKSD 628
>gi|27368849|emb|CAD59582.1| MDR-like ABC transporter [Oryza sativa
(japonica cultivar-group)]
gi|38344910|emb|CAD41854.2| OSJNBb0079B02.13 [Oryza sativa (japonica
cultivar-group)]
gi|38347317|emb|CAE05967.2| OSJNBa0063C18.8 [Oryza sativa (japonica
cultivar-group)]
Length = 1268
Score = 644 bits (1662), Expect = 0.0
Identities = 411/1253 (32%), Positives = 643/1253 (50%), Gaps = 54/1253 (4%)
Frame = -1
Query: 3627 EKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNA 3448
+K+ Q +F +F + ++ L G L +L G P FG++
Sbjct: 32 KKRADQAVAF-HELFTFADKWDLVLMAAGSLGALAHGAAMPLFFLLFGDL---------- 80
Query: 3447 INNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRK 3268
IN + DL +E +++ +F G + + A Y G+ +RK
Sbjct: 81 INGFGKNQTDLRTMTDE----VSKYALYFVYLGLVVCASSYAEIACWMYTGERQVIALRK 136
Query: 3267 QYISRLLKKDAQYFDS-VSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAF 3091
Y+ +L++D +FD+ TG + ++ + ++ EK+ I ++ F G + F
Sbjct: 137 AYLDAVLRQDVGFFDTDARTGDIVFGVSTDTLLVQDAIGEKVGNFIHYIATFLAGLVVGF 196
Query: 3090 YTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLN 2911
WRLA + IAF+G + + + T K YANAG +A Q + +TV S
Sbjct: 197 VAAWRLALLSVAVIPAIAFAGGLYAYTLTGLTSKSRESYANAGVVAEQAIAQVRTVYSFA 256
Query: 2910 GQKTEIERYTEELKAGEKYGIRRALMYSISRGVTY-FFCNSLNTVVLYVGA--------- 2761
G+ + Y+E ++ K G + + + G TY C S V Y G
Sbjct: 257 GESKALNSYSEAIQNTLKLGYKAGMAKGLGIGCTYGIACMSWALVFWYAGVFIRNGQTDG 316
Query: 2760 ----TMIYSGTL-----------------------ETAVVVRDDNVIEKDETDYDVEVEV 2662
T I+S + + V+R I D D + EV
Sbjct: 317 GKAFTAIFSAIVGGMSLGQAFSNLGAFSKGKIAGYKLLEVIRQKPSIVHDHKDGKLLAEV 376
Query: 2661 NGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDS 2482
+GNI FK+V FSYP+RPD + + S + +A+VG SGSGKSTVV L+ +Y+ +
Sbjct: 377 HGNIEFKDVTFSYPSRPDVMIFRDFSLFFPAAKTVAVVGGSGSGKSTVVALIERFYDPNE 436
Query: 2481 GNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKAN 2302
G + +D +D+ + ++ LR IG+V+QEP LF TTI ENI +G P+ ++ E+ A +N
Sbjct: 437 GQVLLDNVDIKTLQLRWLRDQIGLVNQEPALFATTIHENILYGKPDATMAEVEAAATASN 496
Query: 2301 AYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQV 2122
A+ F+ + P G T+VGERG QLSGGQKQRIAIAR +++NPKILLLDEATSALD SE +
Sbjct: 497 AHSFISTLPNGYNTMVGERGIQLSGGQKQRIAIARAMLKNPKILLLDEATSALDAGSENI 556
Query: 2121 VQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAK--RGVYNDLV 1948
VQ+AL+ GRTT+VVAHRLSTIRN + I V+Q+G++VE G HDEL+AK G Y L+
Sbjct: 557 VQEALDRLMTGRTTVVVAHRLSTIRNVNMIAVIQQGQVVETGTHDELLAKGSSGAYASLI 616
Query: 1947 QAQLLESHDD-----------HEELPPLAARQLSQELSPLHSYAIQRSTSNDAGVHDDDM 1801
+ Q + + D L+ + LS L + + Q ST + + +M
Sbjct: 617 RFQEMAQNRDLGGASTRRSRSMHLTSSLSTKSLSLRSGSLRNLSYQYSTGANGRI---EM 673
Query: 1800 ERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFA 1621
D K A + +++K P++ + + GS + G P A ++ + F
Sbjct: 674 ISNADNDRKYPAPRGYFFKLLKLNAPEWPYAVLGAVGSVLSGFIGPTFAIVMGEMLDVFY 733
Query: 1620 MIG-EDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPC 1444
+M + L+ ++ ++ + Q+Y+F + E L+TR+R S +L+
Sbjct: 734 YRDPNEMEKKTKLYVFIYIGTGLYAVVAYLVQHYFFSIMGENLTTRVRRMMLSAILTNEV 793
Query: 1443 AFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEV 1264
++D+ ++++ ++ RL D+++VK+A+ +R+ ++ + ++ + + W++ L +
Sbjct: 794 GWFDEEENNSSLVAARLAVDAADVKSAIAERISVILQNMTSLMTSFIVGFIIEWRVALLI 853
Query: 1263 LMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLIS 1084
L FP + A S+ A E + N+RTV A N ++KI+SL S
Sbjct: 854 LATFPLLVLANFAQQLSMKGFAGDTAKAHAKSSMVAGEGVSNIRTVAAFNAQNKILSLFS 913
Query: 1083 EHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTL 904
L+ + +R+ G GLS C ++ +G++L V + L
Sbjct: 914 YELRIPEQQILRRSQTSGLLFGLSQLCLYSSEALILWYGSHLVRSHGSTFSKVIKVFVVL 973
Query: 903 SMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATM-PFSSSDGKKNIEKGEIIGENVQ 727
+TAN + P+ + + IF + + P + +G+I +V
Sbjct: 974 VVTANSVAETVSLAPEIVRGGESIRSIFGILNRATRIEPDDPESERVTNVRGDIELRHVD 1033
Query: 726 FHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENV 547
F Y RPD I NLK+ G++ ALVG SG GKST+I+L+ERFY G+V ID +++
Sbjct: 1034 FAYPARPDIQIFKDFNLKIQAGRSQALVGASGSGKSTVIALIERFYDPTGGKVTIDGKDI 1093
Query: 546 EDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFP 367
+NL LR + LV QEP LF SI EN+ YG + + E+ +A +TAN FV Q P
Sbjct: 1094 RRLNLKALRLKIGLVQQEPVLFAASILENIAYGKDGATEE-EVIQAAKTANVHGFVSQLP 1152
Query: 366 QGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTAS 187
G T VGERG QLSGGQKQRIAIARA+L++P +LLLDEATSALD++SE V+Q AL+
Sbjct: 1153 NGYKTAVGERGVQLSGGQKQRIAIARAVLKDPAILLLDEATSALDAESECVLQEALERLM 1212
Query: 186 ERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELL-RKRSIYWRLVQKQ 31
+ +TV+VAHRLST+ D IAV+++G++ E G+H +L+ R Y RL+Q Q
Sbjct: 1213 KGRTTVLVAHRLSTIRGVDRIAVVQDGRIVEHGSHSDLVSRPEGAYSRLLQLQ 1265
>gi|157873|gb|AAA16186.1| P-glycoprotein/multidrug resistance protein
Length = 1283
Score = 644 bits (1660), Expect = 0.0
Identities = 416/1255 (33%), Positives = 657/1255 (52%), Gaps = 54/1255 (4%)
Frame = -1
Query: 3633 SDEKKPSQICSFIRVV-----FKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQV 3469
SDE+ S+ ++ V F+ ++ ++ L+++G+L ++ TG P S FG ++
Sbjct: 29 SDEEDGSEYHEDVKQVSYFQLFRYATKKDRALYVIGLLSAVGTGLTTPANSLIFGNLAND 88
Query: 3468 LVTITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDN 3289
++ ++ + + AD + ++ + Q G + + L Y +
Sbjct: 89 MIDLSGLLESGKSYRADDAISTLLLDK-VRQFSLQNTYIGMIMLVCSYLSITCFNYAAHS 147
Query: 3288 TTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTL 3109
+R ++ +L +D +++D +G +++ +N++L + + EK+ + + ++ F
Sbjct: 148 QILTIRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVG 207
Query: 3108 GTALAFYTDWRLASYGIFFSLGIAFSGF-INSAGVMKTTGKQNTHYANAGSIAFQTLGAY 2932
LAF W+L S SL + F + + + K+ T YA A +A L
Sbjct: 208 SLVLAFVKGWQL-SLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGI 266
Query: 2931 KTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVT-YFFCNSLNTVVLYVGATM 2755
+TV + G+ E+ Y E + A + I+R + I G+ +FF + + + G +
Sbjct: 267 RTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLWFFFIYASYALAFWYGVGL 326
Query: 2754 IY--------SGTLET---AVVVRDDNV-----------------------IEK--DETD 2683
+ +GT+ T +V++ N+ IE+ +
Sbjct: 327 VIESAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAQGRLPKVFHIIEQIPEINP 386
Query: 2682 YDVEVEVNG---NISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQ 2512
V+VN I FK V+F YPTRP+ +L ++ + G+ +ALVG SG GKST +Q
Sbjct: 387 LMGRVKVNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQ 446
Query: 2511 LLLHYYNIDSGNIFIDGMDLNDMNIKRLRRV-IGVVSQEPVLFNTTIEENIRFGNPNVSL 2335
L+ +Y+ +GN+ +G +L D++I LR + IGVV QEP+LF T+I ENIR+G + +
Sbjct: 447 LVQRFYDPQAGNLLFNGTNLKDLDINWLRFLRIGVVGQEPILFATSIYENIRYGREDATR 506
Query: 2334 PEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEA 2155
EI A ANA F+ PKG T+VGERG QLSGGQKQRIAI R L+R+P+ILLLDEA
Sbjct: 507 EEIEAARAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIRRALIRDPEILLLDEA 566
Query: 2154 TSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIA 1975
TSALD SE VQ ALE S GRTTI+VAHRLST+R A +I+V+ KGE+VE G H EL+
Sbjct: 567 TSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELME 626
Query: 1974 KRGVYNDLVQAQLLESHDDHEELPPLAARQLSQELSPLHSYAIQ---RSTSNDAGVHDDD 1804
+ Y +LV QL E DD L P + ++ I+ D V D+
Sbjct: 627 LKDHYFNLVTTQLGE--DDGSVLSPTGDIYKNFDIKDEDEEEIKVLSEDEDEDVMVTDEK 684
Query: 1803 MERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGF 1624
++ + K+ + + E++K +P++ + + S I G + PI A L +
Sbjct: 685 NKKKKMKKVKDPNEVKPMLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGSILQIL 744
Query: 1623 AMIGEDMLY--YSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSL 1450
++ D S+ ++L F+ + + + Q Y+FG E+L+ RLR F ML
Sbjct: 745 SVKDNDQYVRENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQ 804
Query: 1449 PCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTL 1270
A++DD + L RL+ D++ V+ A R+G +I ++ +++ I + Y W + L
Sbjct: 805 EVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIIQSISTLALGIALSMYYEWSLGL 864
Query: 1269 EVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSL 1090
L F P EN + A+E + N+RTV +L E+
Sbjct: 865 VALAFTPFILIAFYMQRTLMAKENMRPAKTMENCTKLAVEVVSNIRTVASLGREEMFHQN 924
Query: 1089 ISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLM 910
L + + +G GL+ S F Y+ +GT+ + + + D + V
Sbjct: 925 YIGMLIPAVEISKRNTHFRGLVYGLARSLMFFAYAACMYYGTWCVIHRGILFGDVFKVSQ 984
Query: 909 TLSMTANMAGSAAAYLPDYKKAVHAAGLIF-HLFTYPATMPFSSSDGKKNIEKGEIIGEN 733
+ M +A A+ P+ +K V AA IF L P+ + +G + +
Sbjct: 985 AVIMGTASIANALAFAPNMQKGVSAAKTIFTFLRRQPSIVDRPGVSRDPWHSEGYVRFDK 1044
Query: 732 VQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSE 553
V+F Y R + +L G+ L V G+ +ALVGPSGCGKST I L++RFY +G ID
Sbjct: 1045 VKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDEC 1104
Query: 552 NVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYG-LTRSVPQLELEKALQTANAFNFVF 376
+V ++++ +LR+ L +VSQEP LF+ +IREN+ YG R+V E+ A + +N F+
Sbjct: 1105 DVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARNVTDQEIISACKKSNIHEFIA 1164
Query: 375 QFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALD 196
P G DT +GE+GAQLSGGQKQRIAIARA++RNPK++LLDEATSALD++SEKVVQ+ALD
Sbjct: 1165 NLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESEKVVQDALD 1224
Query: 195 TASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
ASE +T+ +AHRLSTVV++D I V +NG V E G H++LL R +Y+ L + Q
Sbjct: 1225 AASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLLANRGLYYTLYKLQ 1279
>gi|1079107|pir||A47377 multidrug resistance protein Mdr50 - fruit fly
(Drosophila melanogaster)
Length = 1283
Score = 644 bits (1660), Expect = 0.0
Identities = 416/1255 (33%), Positives = 657/1255 (52%), Gaps = 54/1255 (4%)
Frame = -1
Query: 3633 SDEKKPSQICSFIRVV-----FKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQV 3469
SDE+ S+ ++ V F+ ++ ++ L+++G+L ++ TG P S FG ++
Sbjct: 29 SDEEDGSEYHEDVKQVSYFQLFRYATKKDRALYVIGLLSAVGTGLTTPANSLIFGNLAND 88
Query: 3468 LVTITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDN 3289
++ ++ + + AD + ++ + Q G + + L Y +
Sbjct: 89 MIDLSGLLESGKSYRADDAISTLLLDK-VRQFSLQNTYIGMIMLVCSYLSITCFNYAAHS 147
Query: 3288 TTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTL 3109
+R ++ +L +D +++D +G +++ +N++L + + EK+ + + ++ F
Sbjct: 148 QILTIRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVG 207
Query: 3108 GTALAFYTDWRLASYGIFFSLGIAFSGF-INSAGVMKTTGKQNTHYANAGSIAFQTLGAY 2932
LAF W+L S SL + F + + + K+ T YA A +A L
Sbjct: 208 SLVLAFVKGWQL-SLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGI 266
Query: 2931 KTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVT-YFFCNSLNTVVLYVGATM 2755
+TV + G+ E+ Y E + A + I+R + I G+ +FF + + + G +
Sbjct: 267 RTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLWFFFIYASYALAFWYGVGL 326
Query: 2754 IY--------SGTLET---AVVVRDDNV-----------------------IEK--DETD 2683
+ +GT+ T +V++ N+ IE+ +
Sbjct: 327 VIESAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAQGRLPKVFHIIEQIPEINP 386
Query: 2682 YDVEVEVNG---NISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQ 2512
V+VN I FK V+F YPTRP+ +L ++ + G+ +ALVG SG GKST +Q
Sbjct: 387 LMGRVKVNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQ 446
Query: 2511 LLLHYYNIDSGNIFIDGMDLNDMNIKRLRRV-IGVVSQEPVLFNTTIEENIRFGNPNVSL 2335
L+ +Y+ +GN+ +G +L D++I LR + IGVV QEP+LF T+I ENIR+G + +
Sbjct: 447 LVQRFYDPQAGNLLFNGTNLKDLDINWLRFLRIGVVGQEPILFATSIYENIRYGREDATR 506
Query: 2334 PEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEA 2155
EI A ANA F+ PKG T+VGERG QLSGGQKQRIAI R L+R+P+ILLLDEA
Sbjct: 507 EEIEAARAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIRRALIRDPEILLLDEA 566
Query: 2154 TSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIA 1975
TSALD SE VQ ALE S GRTTI+VAHRLST+R A +I+V+ KGE+VE G H EL+
Sbjct: 567 TSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELME 626
Query: 1974 KRGVYNDLVQAQLLESHDDHEELPPLAARQLSQELSPLHSYAIQ---RSTSNDAGVHDDD 1804
+ Y +LV QL E DD L P + ++ I+ D V D+
Sbjct: 627 LKDHYFNLVTTQLGE--DDGSVLSPTGDIYKNFDIKDEDEEEIKVLSEDEDEDVMVTDEK 684
Query: 1803 MERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGF 1624
++ + K+ + + E++K +P++ + + S I G + PI A L +
Sbjct: 685 NKKKKMKKVKDPNEVKPMLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGSILQIL 744
Query: 1623 AMIGEDMLY--YSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSL 1450
++ D S+ ++L F+ + + + Q Y+FG E+L+ RLR F ML
Sbjct: 745 SVKDNDQYVRENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQ 804
Query: 1449 PCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTL 1270
A++DD + L RL+ D++ V+ A R+G +I ++ +++ I + Y W + L
Sbjct: 805 EVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIIQSISTLALGIALSMYYEWSLGL 864
Query: 1269 EVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSL 1090
L F P EN + A+E + N+RTV +L E+
Sbjct: 865 VALAFTPFILIAFYMQRTLMAKENMRPAKTMENCTKLAVEVVSNIRTVASLGREEMFHQN 924
Query: 1089 ISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLM 910
L + + +G GL+ S F Y+ +GT+ + + + D + V
Sbjct: 925 YIGMLIPAVEISKRNTHFRGLVYGLARSLMFFAYAACMYYGTWCVIHRGILFGDVFKVSQ 984
Query: 909 TLSMTANMAGSAAAYLPDYKKAVHAAGLIF-HLFTYPATMPFSSSDGKKNIEKGEIIGEN 733
+ M +A A+ P+ +K V AA IF L P+ + +G + +
Sbjct: 985 AVIMGTASIANALAFAPNMQKGVSAAKTIFTFLRRQPSIVDRPGVSRDPWHSEGYVRFDK 1044
Query: 732 VQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSE 553
V+F Y R + +L G+ L V G+ +ALVGPSGCGKST I L++RFY +G ID
Sbjct: 1045 VKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDEC 1104
Query: 552 NVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYG-LTRSVPQLELEKALQTANAFNFVF 376
+V ++++ +LR+ L +VSQEP LF+ +IREN+ YG R+V E+ A + +N F+
Sbjct: 1105 DVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARNVTDQEIISACKKSNIHEFIA 1164
Query: 375 QFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALD 196
P G DT +GE+GAQLSGGQKQRIAIARA++RNPK++LLDEATSALD++SEKVVQ+ALD
Sbjct: 1165 NLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESEKVVQDALD 1224
Query: 195 TASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
ASE +T+ +AHRLSTVV++D I V +NG V E G H++LL R +Y+ L + Q
Sbjct: 1225 AASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLLANRGLYYTLYKLQ 1279
>gi|15228695|ref|NP_191774.1| multidrug resistant (MDR) ABC
transporter, putative [Arabidopsis thaliana]
gi|11277353|pir||T48007 P-glycoprotein homolog T17J13.110
[similarity] - Arabidopsis thaliana
gi|6899925|emb|CAB71875.1| P-glycoprotein-like proetin [Arabidopsis
thaliana]
Length = 1292
Score = 643 bits (1659), Expect = 0.0
Identities = 411/1239 (33%), Positives = 637/1239 (51%), Gaps = 55/1239 (4%)
Frame = -1
Query: 3588 VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEK 3409
+F + F+ L +LG + ++ G P M+ FG+V V N + D +D
Sbjct: 68 LFAFADSFDIILMILGTIGAVGNGLGFPIMTILFGDVIDVF-----GQNQNSSDVSDK-- 120
Query: 3408 AYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQY 3229
+ +V F G + A LQ + G+ R+R Y+ +L++D +
Sbjct: 121 --------IAKVALKFVYLGLGTLVAALLQVSGWMISGERQAGRIRSLYLQTILRQDIAF 172
Query: 3228 FD-SVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFF 3052
FD +TG + ++ + ++ EK+ I V+ F G +AF W L +
Sbjct: 173 FDVETNTGEVVGRMSGDTVLIQDAMGEKVGKAIQLVSTFIGGFVIAFTEGWLLTLVMVSS 232
Query: 3051 SLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEEL 2872
+ SG + + K + T YA A + QT+G+ +TV S G+K I Y + L
Sbjct: 233 IPLLVMSGAALAIVISKMASRGQTSYAKAAVVVEQTVGSIRTVASFTGEKQAISNYNKHL 292
Query: 2871 KAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMI----YSGTLETAVV------ 2722
+ + G+ + G + ++ G MI Y+G ++
Sbjct: 293 VSAYRAGVFEGASTGLGLGTLNIVIFCTYALAVWYGGKMILEKGYTGGQVLIIIFAVLTG 352
Query: 2721 ---------------------------VRDDNVIEKDETDYDVEVEVNGNISFKNVKFSY 2623
++ I+ +T V ++ G+I NV FSY
Sbjct: 353 SMSLGQASPCLSAFAAGQAAAYKMFEAIKRKPEIDASDTTGKVLDDIRGDIELNNVNFSY 412
Query: 2622 PTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDM 2443
P RP+ Q+ +G S + +G +ALVG SGSGKSTVV L+ +Y+ SG + IDG++L +
Sbjct: 413 PARPEEQIFRGFSLSISSGSTVALVGQSGSGKSTVVSLIERFYDPQSGEVRIDGINLKEF 472
Query: 2442 NIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIK 2263
+K +R IG+VSQEPVLF ++I+ENI +G N ++ EI A ANA F+ P+G+
Sbjct: 473 QLKWIRSKIGLVSQEPVLFTSSIKENIAYGKENATVEEIRKATELANASKFIDKLPQGLD 532
Query: 2262 TIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRT 2083
T+VGE GTQLSGGQKQRIA+AR ++++P+ILLLDEATSALD ESE++VQ+AL+ RT
Sbjct: 533 TMVGEHGTQLSGGQKQRIAVARAILKDPRILLLDEATSALDAESERIVQEALDRIMVNRT 592
Query: 2082 TIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIA-KRGVYNDLVQAQ----LLESHDD 1918
T+VVAHRLST+RNA I V+ +G+IVE G+H EL+ G Y+ L++ Q E D
Sbjct: 593 TVVVAHRLSTVRNADMIAVIHQGKIVEKGSHSELLRDPEGAYSQLIRLQEDTKQTEDSTD 652
Query: 1917 HEELPPLAARQLSQELSPLHSYAIQRSTSND-----AGVHDDDMERILDELSKEGA---- 1765
++L + ++ S S L +RS+S AG+ D + E I ++ K
Sbjct: 653 EQKLSMESMKRSSLRKSSLSRSLSKRSSSFSMFGFPAGI-DTNNEAIPEKDIKVSTPIKE 711
Query: 1764 KKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYYSHL 1585
KK + + +P+ L + + + GV PI LI + F E + +
Sbjct: 712 KKVSFFRVAALNKPEIPMLILGSIAAVLNGVILPIFGILISSVIKAFFKPPEQLKSDTRF 771
Query: 1584 WALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRL 1405
WA+ FM L V + Q +F +L R+R F ++ + ++D+ +S+ +
Sbjct: 772 WAIIFMLLGVASMVVFPAQTIFFSIAGCKLVQRIRSMCFEKVVRMEVGWFDETENSSGAI 831
Query: 1404 SNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXX 1225
RL+ D++ V+ V D L + + +++ + A + W++ VL P
Sbjct: 832 GARLSADAATVRGLVGDALAQTVQNLASVTAGLVIAFVASWQLAFIVLAMLPLIGLNGYI 891
Query: 1224 XXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKR 1045
+ + +++ A +A+ ++RTV + E+K+M + + + ++ ++
Sbjct: 892 YMKFMVGFSAD----AKEASQVANDAVGSIRTVASFCAEEKVMKMYKKKCEGPMRTGIRQ 947
Query: 1044 AIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAY 865
I+ G G+S Y+ SF G L + + V L+M A +++
Sbjct: 948 GIVSGIGFGVSFFVLFSSYAASFYAGARLVDDGKTTFDSVFRVFFALTMAAVAISQSSSL 1007
Query: 864 LPDYKKAVHAAGLIFHLFTYPATMPFSSSDGK--KNIEKGEIIGENVQFHYDQRPDRMIL 691
PD KA +AA IF + + + S G+ N+ KG+I ++ F Y RPD I
Sbjct: 1008 SPDSSKASNAAASIFAVIDRESKIDPSDESGRVLDNV-KGDIELRHISFKYPSRPDVQIF 1066
Query: 690 NGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNL 511
+ L + GKT+ALVG SG GKST+I+LL+RFY G++ +D ++ + L LR
Sbjct: 1067 QDLCLSIRAGKTIALVGESGSGKSTVIALLQRFYDPDSGQITLDGVEIKTLQLKWLRQQT 1126
Query: 510 ALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGA 331
LVSQEP LFN +IR N+ YG + E+ A + +NA F+ QG DT+VGERG
Sbjct: 1127 GLVSQEPVLFNETIRANIAYGKGGDATETEIVSAAELSNAHGFISGLQQGYDTMVGERGV 1186
Query: 330 QLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRL 151
QLSGGQKQR+AIARAI+++PKVLLLDEATSALD++SE+VVQ+ALD +TVVVAHRL
Sbjct: 1187 QLSGGQKQRVAIARAIVKDPKVLLLDEATSALDAESERVVQDALDRVMVNRTTVVVAHRL 1246
Query: 150 STVVNADSIAVLKNGKVAEQGTHEELLR-KRSIYWRLVQ 37
ST+ NAD IAV+KNG + E+G HE L+ K +Y LVQ
Sbjct: 1247 STIKNADVIAVVKNGVIVEKGKHETLINIKDGVYASLVQ 1285
Score = 296 bits (757), Expect = 3e-78
Identities = 191/572 (33%), Positives = 298/572 (51%), Gaps = 8/572 (1%)
Frame = -1
Query: 1722 DYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMI--GEDMLYYSHLWALSFMFLAVFR 1549
D + + G+ G+ +PI+ L + F D+ AL F++L +
Sbjct: 76 DIILMILGTIGAVGNGLGFPIMTILFGDVIDVFGQNQNSSDVSDKIAKVALKFVYLGLGT 135
Query: 1548 PLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVK 1369
+ Q + E+ + R+R +L AF+D ++ + R++ D+ ++
Sbjct: 136 LVAALLQVSGWMISGERQAGRIRSLYLQTILRQDIAFFDVETNTG-EVVGRMSGDTVLIQ 194
Query: 1368 AAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQED 1189
A+ +++G I V A W +TL ++ P
Sbjct: 195 DAMGEKVGKAIQLVSTFIGGFVIAFTEGWLLTLVMVSSIPLLVMSGAALAIVISKMASRG 254
Query: 1188 TIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSL 1009
++ + + + ++RTV + E + +S ++HL S ++ + +GA+ GL L
Sbjct: 255 QTSYAKAAVVVEQTVGSIRTVASFTGEKQAISNYNKHL----VSAYRAGVFEGASTGLGL 310
Query: 1008 SCFLFV----YSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAV 841
V Y+++ +G + L K +++ + + G A+ L +
Sbjct: 311 GTLNIVIFCTYALAVWYGGKMILEKGYTGGQVLIIIFAVLTGSMSLGQASPCLSAFAAGQ 370
Query: 840 HAAGLIFHLFTYPATMPFSSSDGKKNIE-KGEIIGENVQFHYDQRPDRMILNGVNLKVDP 664
AA +F + S + GK + +G+I NV F Y RP+ I G +L +
Sbjct: 371 AAAYKMFEAIKRKPEIDASDTTGKVLDDIRGDIELNNVNFSYPARPEEQIFRGFSLSISS 430
Query: 663 GKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTL 484
G T+ALVG SG GKST++SL+ERFY GEV+ID N+++ L +RS + LVSQEP L
Sbjct: 431 GSTVALVGQSGSGKSTVVSLIERFYDPQSGEVRIDGINLKEFQLKWIRSKIGLVSQEPVL 490
Query: 483 FNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQR 304
F SI+EN+ YG + + E+ KA + ANA F+ + PQGLDT+VGE G QLSGGQKQR
Sbjct: 491 FTSSIKENIAYGKENATVE-EIRKATELANASKFIDKLPQGLDTMVGEHGTQLSGGQKQR 549
Query: 303 IAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSI 124
IA+ARAIL++P++LLLDEATSALD++SE++VQ ALD +TVVVAHRLSTV NAD I
Sbjct: 550 IAVARAILKDPRILLLDEATSALDAESERIVQEALDRIMVNRTTVVVAHRLSTVRNADMI 609
Query: 123 AVLKNGKVAEQGTHEELLR-KRSIYWRLVQKQ 31
AV+ GK+ E+G+H ELLR Y +L++ Q
Sbjct: 610 AVIHQGKIVEKGSHSELLRDPEGAYSQLIRLQ 641
Score = 294 bits (753), Expect = 9e-78
Identities = 184/521 (35%), Positives = 276/521 (52%), Gaps = 42/521 (8%)
Frame = -1
Query: 3363 FFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSV--STGHLSTVL 3190
F L G A + Q G R+R ++++ + +FD S+G + L
Sbjct: 776 FMLLGVASMVVFPAQTIFFSIAGCKLVQRIRSMCFEKVVRMEVGWFDETENSSGAIGARL 835
Query: 3189 NDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAG 3010
+ + R + + +A + + T G +AF W+LA + I +G+I
Sbjct: 836 SADAATVRGLVGDALAQTVQNLASVTAGLVIAFVASWQLAFIVLAMLPLIGLNGYI---- 891
Query: 3009 VMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMY 2830
MK + A +A +G+ +TV S ++ ++ Y ++ + + GIR+ ++
Sbjct: 892 YMKFMVGFSADAKEASQVANDAVGSIRTVASFCAEEKVMKMYKKKCEGPMRTGIRQGIVS 951
Query: 2829 SISRGVTYFFCNSLNTVVLYVGATMIYSG--TLET------------------------- 2731
I GV++F S Y GA ++ G T ++
Sbjct: 952 GIGFGVSFFVLFSSYAASFYAGARLVDDGKTTFDSVFRVFFALTMAAVAISQSSSLSPDS 1011
Query: 2730 -----------AVVVRDDNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGIS 2584
AV+ R+ + DE+ ++ V G+I +++ F YP+RPD Q+ + +
Sbjct: 1012 SKASNAAASIFAVIDRESKIDPSDESGRVLD-NVKGDIELRHISFKYPSRPDVQIFQDLC 1070
Query: 2583 FDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVS 2404
++ G+ IALVG SGSGKSTV+ LL +Y+ DSG I +DG+++ + +K LR+ G+VS
Sbjct: 1071 LSIRAGKTIALVGESGSGKSTVIALLQRFYDPDSGQITLDGVEIKTLQLKWLRQQTGLVS 1130
Query: 2403 QEPVLFNTTIEENIRFG-NPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSG 2227
QEPVLFN TI NI +G + + EI A +NA+ F+ +G T+VGERG QLSG
Sbjct: 1131 QEPVLFNETIRANIAYGKGGDATETEIVSAAELSNAHGFISGLQQGYDTMVGERGVQLSG 1190
Query: 2226 GQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIR 2047
GQKQR+AIAR +V++PK+LLLDEATSALD ESE+VVQ AL+ RTT+VVAHRLSTI+
Sbjct: 1191 GQKQRVAIARAIVKDPKVLLLDEATSALDAESERVVQDALDRVMVNRTTVVVAHRLSTIK 1250
Query: 2046 NASKIIVMQKGEIVEVGNHDELI-AKRGVYNDLVQAQLLES 1927
NA I V++ G IVE G H+ LI K GVY LVQ L S
Sbjct: 1251 NADVIAVVKNGVIVEKGKHETLINIKDGVYASLVQLHLSAS 1291
>gi|22328760|ref|NP_193539.2| ABC transporter family protein
[Arabidopsis thaliana]
Length = 1281
Score = 643 bits (1659), Expect = 0.0
Identities = 421/1240 (33%), Positives = 639/1240 (50%), Gaps = 59/1240 (4%)
Frame = -1
Query: 3615 SQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNK 3436
+Q SF ++ F + + L +G + + G QPFM+ FG+ + NA
Sbjct: 13 NQKVSFFKL-FSFADKTDVVLMTVGTIAAAGNGLTQPFMTLIFGQ-------LINAFG-- 62
Query: 3435 TIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYIS 3256
T DP + R + +V F + A LQ + G+ + +R Y+
Sbjct: 63 TTDP-------DHMVREVWKVAVKFIYLAVYSCVVAFLQVSCWMVTGERQSATIRGLYLK 115
Query: 3255 RLLKKDAQYFDS-VSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDW 3079
+L++D YFD+ +TG + ++ + ++ EK+ + F G A+AFY
Sbjct: 116 TILRQDIGYFDTETNTGEVIGRMSGDTILIQDAMGEKVGKFTQLLCTFLGGFAIAFYKGP 175
Query: 3078 RLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKT 2899
LA I +G S + K G+ YA AG++ QT+GA +TV + G+K
Sbjct: 176 LLAGVLCSCIPLIVIAGAAMSLIMSKMAGRGQVAYAEAGNVVEQTVGAIRTVVAFTGEKQ 235
Query: 2898 EIERYTEELKAGEKYGIRRALMYSISRG--VTYFFCNSLNTVVLYVGATMI----YSGTL 2737
E+Y +L+ K +++ L+ G + FC+ + ++ GA +I Y+G
Sbjct: 236 ATEKYESKLEIAYKTVVQQGLISGFGLGTMLAVIFCSY--GLAVWYGAKLIMEKGYNGGQ 293
Query: 2736 ETAVV---------------------------------VRDDNVIEKDETDYDVEVEVNG 2656
V+ ++ I+ + V ++ G
Sbjct: 294 VINVIFAVLTGGMSLGQTSPSLNAFAAGRAAAFKMFETIKRSPKIDAYDMSGSVLEDIRG 353
Query: 2655 NISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGN 2476
+I K+V F YP RPD Q+ G S V NG+ +ALVG SGSGKSTV+ L+ +Y+ +SG
Sbjct: 354 DIELKDVYFRYPARPDVQIFAGFSLFVPNGKTVALVGQSGSGKSTVISLIERFYDPESGQ 413
Query: 2475 IFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAY 2296
+ ID +DL + +K +R IG+VSQEPVLF TTI+ENI +G + + EI A+ ANA
Sbjct: 414 VLIDNIDLKKLQLKWIRSKIGLVSQEPVLFATTIKENIAYGKEDATDQEIRTAIELANAA 473
Query: 2295 DFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQ 2116
F+ P+G+ T+VGE GTQ+SGGQKQR+AIAR +++NPKILLLDEATSALD ESE++VQ
Sbjct: 474 KFIDKLPQGLDTMVGEHGTQMSGGQKQRLAIARAILKNPKILLLDEATSALDAESERIVQ 533
Query: 2115 KALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIA-KRGVYNDLVQAQ 1939
AL N RTT+VVAHRL+TIR A I V+ +G+IVE G HDE+I G Y+ LV+ Q
Sbjct: 534 DALVNLMSNRTTVVVAHRLTTIRTADVIAVVHQGKIVEKGTHDEMIQDPEGAYSQLVRLQ 593
Query: 1938 LLESHDDHEELPPLAARQLSQELSPLHSYAIQRSTSNDA----------------GVHDD 1807
+ E P + + + S S A++RS S ++ GV+ +
Sbjct: 594 EGSKEEATESERPETSLDVERSGSLRLSSAMRRSVSRNSSSSRHSFSLASNMFFPGVNVN 653
Query: 1806 DMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEG 1627
+ + DE + KK +L+ + +P+ L + + + G +PI L+ +
Sbjct: 654 QTDEMEDEENNVRHKKVSLKRLAHLNKPEIPVLVLGSIAAMVHGTVFPIFGLLLSSSINM 713
Query: 1626 FAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLP 1447
F + + SH WAL ++ L + + + Y+FG +L R+R F ++
Sbjct: 714 FYEPAKILKKDSHFWALIYIALGLTNFVMIPVPNYFFGIAGGKLIKRIRSMCFDKVVHQE 773
Query: 1446 CAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLE 1267
+++D D++N ++ V D L ++ + ++ + A W + L
Sbjct: 774 ISWFD---------------DTANSRSLVGDALALIVQNIATVTTGLIIAFTANWILALI 818
Query: 1266 VLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLI 1087
VL P + +E +++ A +A+ ++RTV + E+K+M L
Sbjct: 819 VLALSPFIVIQGYAQTKFLTGFSADAKAMYEEASQVANDAVSSIRTVASFCAEEKVMDLY 878
Query: 1086 SEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMT 907
+ K+ + ++ GA G S + V F G L + + + V
Sbjct: 879 QQKCDGPKKNGVRLGLLSGAGFGFSFFFLYCINCVCFVSGAGLIQIGKATFGEVFKVFFA 938
Query: 906 LSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGK--KNIEKGEIIGEN 733
L++ A +A PD KA +A IF + + SS +G +N+ G+I +
Sbjct: 939 LTIMAIGVSQTSAMAPDSNKAKDSAASIFDILDSTPKIDSSSDEGTTLQNV-NGDIEFRH 997
Query: 732 VQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSE 553
V F Y RPD I + L + GKT+ALVG SG GKST+IS++ERFY+ G++ ID
Sbjct: 998 VSFRYPMRPDVQIFRDLCLTIPSGKTVALVGESGSGKSTVISMIERFYNPDSGKILIDQV 1057
Query: 552 NVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQ 373
++ L+ LR + LVSQEP LFN +IR N+ YG T + E+ A + ANA NF+
Sbjct: 1058 EIQTFKLSWLRQQMGLVSQEPILFNETIRSNIAYGKTGGATEEEIIAAAKAANAHNFISS 1117
Query: 372 FPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDT 193
PQG DT VGERG QLSGGQKQRIAIARAIL++PK+LLLDEATSALD++SE+VVQ+ALD
Sbjct: 1118 LPQGYDTSVGERGVQLSGGQKQRIAIARAILKDPKILLLDEATSALDAESERVVQDALDR 1177
Query: 192 ASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEEL 73
+TVVVAHRL+T+ NAD IAV+KNG +AE+G HE L
Sbjct: 1178 VMVNRTTVVVAHRLTTIKNADVIAVVKNGVIAEKGRHETL 1217
Score = 268 bits (686), Expect = 5e-70
Identities = 180/571 (31%), Positives = 288/571 (49%), Gaps = 5/571 (0%)
Frame = -1
Query: 1728 RPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYYSHLW--ALSFMFLAV 1555
+ D + + +A G++ P + + + F D + +W A+ F++LAV
Sbjct: 27 KTDVVLMTVGTIAAAGNGLTQPFMTLIFGQLINAFGTTDPDHMV-REVWKVAVKFIYLAV 85
Query: 1554 FRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSN 1375
+ + + Q + E+ S +R +L ++D ++ + R++ D+
Sbjct: 86 YSCVVAFLQVSCWMVTGERQSATIRGLYLKTILRQDIGYFDTETNTG-EVIGRMSGDTIL 144
Query: 1374 VKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMF-FPXXXXXXXXXXXXXXXAI 1198
++ A+ +++G + A Y + VL P
Sbjct: 145 IQDAMGEKVGKFTQLLCTFLGGFAIA-FYKGPLLAGVLCSCIPLIVIAGAAMSLIMSKMA 203
Query: 1197 QEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANG 1018
+A+ + + + +RTV A E + L+ +K+ ++ +I G G
Sbjct: 204 GRGQVAYAEAGNVVEQTVGAIRTVVAFTGEKQATEKYESKLEIAYKTVVQQGLISGFGLG 263
Query: 1017 LSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVH 838
L+ Y ++ +G L + K V+ + G + L +
Sbjct: 264 TMLAVIFCSYGLAVWYGAKLIMEKGYNGGQVINVIFAVLTGGMSLGQTSPSLNAFAAGRA 323
Query: 837 AAGLIFHLFTY-PATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPG 661
AA +F P + S +G+I ++V F Y RPD I G +L V G
Sbjct: 324 AAFKMFETIKRSPKIDAYDMSGSVLEDIRGDIELKDVYFRYPARPDVQIFAGFSLFVPNG 383
Query: 660 KTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLF 481
KT+ALVG SG GKST+ISL+ERFY G+V ID+ +++ + L +RS + LVSQEP LF
Sbjct: 384 KTVALVGQSGSGKSTVISLIERFYDPESGQVLIDNIDLKKLQLKWIRSKIGLVSQEPVLF 443
Query: 480 NCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRI 301
+I+EN+ YG + Q E+ A++ ANA F+ + PQGLDT+VGE G Q+SGGQKQR+
Sbjct: 444 ATTIKENIAYGKEDATDQ-EIRTAIELANAAKFIDKLPQGLDTMVGEHGTQMSGGQKQRL 502
Query: 300 AIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIA 121
AIARAIL+NPK+LLLDEATSALD++SE++VQ+AL +TVVVAHRL+T+ AD IA
Sbjct: 503 AIARAILKNPKILLLDEATSALDAESERIVQDALVNLMSNRTTVVVAHRLTTIRTADVIA 562
Query: 120 VLKNGKVAEQGTHEELLR-KRSIYWRLVQKQ 31
V+ GK+ E+GTH+E+++ Y +LV+ Q
Sbjct: 563 VVHQGKIVEKGTHDEMIQDPEGAYSQLVRLQ 593
>gi|19032275|dbj|BAB85651.1| multidrug resistance protein 1 homolog
[Triticum aestivum]
Length = 1262
Score = 642 bits (1656), Expect = 0.0
Identities = 403/1246 (32%), Positives = 656/1246 (52%), Gaps = 62/1246 (4%)
Frame = -1
Query: 3588 VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEK 3409
+F+ + + L ++G L ++ G +P +S FG+V N+ T
Sbjct: 33 MFRYADRLDMLLMVVGSLGAVGNGVSEPLISVLFGDV-------INSFGESTTSTV---- 81
Query: 3408 AYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQY 3229
R + +VV +F G + + LQ A G+ + R+R Y+ +L++D +
Sbjct: 82 -----LRAVTKVVLNFIYLGIGTAVASFLQVACWTMAGERQSARIRSLYLKSVLRQDIAF 136
Query: 3228 FDS-VSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFF 3052
FD+ ++TG + ++ + ++ EK ++ + F G +AF W L +
Sbjct: 137 FDTEMTTGEAVSRMSSDTVIIQDALGEKAGKLVQLTSAFFGGFIIAFTKGWLLTLVMLTS 196
Query: 3051 SLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEEL 2872
+A +G +++ + + + K+ T Y++A + QT+G+ +TV S NG+K IE Y + +
Sbjct: 197 LPLVAIAGAVSAQMLTRVSSKRLTSYSDAANTVEQTIGSIRTVVSFNGEKKAIEMYNKFI 256
Query: 2871 KAGEKYGIRRALMYSISRGVTYFFCNS----------------------LNTVVLYV--G 2764
K+ + + L+ G + S + TV+ V G
Sbjct: 257 KSAYRTVVEEGLVNGFGMGSVFCILFSSYGLAFWYGGKLIIDKGYTGGKIVTVLFAVLNG 316
Query: 2763 ATMIYSGTLETAVVVRDDNV-------------IEKDETDYDVEVEVNGNISFKNVKFSY 2623
AT + + T + + + I+ D+T + + G + K+V F Y
Sbjct: 317 ATSLGNATPSISAIAEGQSAAYRLFETIERKPEIDSDDTSGMIMENIKGYVELKDVYFRY 376
Query: 2622 PTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDM 2443
P R +L G+S V +G +A+VG SGSGKSTV+ L+ +Y+ +G + IDG+++ ++
Sbjct: 377 PARLGQLILDGLSLQVASGTTMAIVGESGSGKSTVISLVERFYDPQAGEVLIDGVNIKNL 436
Query: 2442 NIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIK 2263
N+ +R IG+VSQEP+LF T+I++NI +G + +L EI A ANA +F+ P G
Sbjct: 437 NLDWIRGKIGLVSQEPLLFMTSIKDNIIYGKEDATLEEIKRAAELANAANFIDKLPNGYD 496
Query: 2262 TIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRT 2083
T+VG+RGT LSGGQKQRIAIAR ++++PKILLLDEATSALD ESE++VQ+AL RT
Sbjct: 497 TLVGQRGTLLSGGQKQRIAIARAILKDPKILLLDEATSALDVESERIVQEALNRIMVERT 556
Query: 2082 TIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAK-RGVYNDLVQAQLLESHDDHEEL 1906
T+VVAHRLST+RN I V+ +G+IVE G H L+ G Y+ L++ Q E+ D E
Sbjct: 557 TLVVAHRLSTVRNVDCITVVHQGKIVEQGTHHALVKDPNGAYSQLIRLQ--ETRGD--ER 612
Query: 1905 PPLAARQLSQELSPLHSYAIQRSTSNDA-----------------GVHDDDM--ERILDE 1783
+ + LS S +I+RS + D+ +H+D++ E+ D+
Sbjct: 613 RKIQDSGVPNSLSKSTSLSIRRSMTKDSFGNSNRYSFKNPLGLSVELHEDEITGEQNKDD 672
Query: 1782 LSK-EGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGED 1606
LS + +K+ + + +P+ FL + +++ GV +P+ L+ + F +
Sbjct: 673 LSNGKTLQKAPIGRLFYLNKPEVPFLLLGAIAASVHGVIFPLFGILMSGVIKAFYEPPDK 732
Query: 1605 MLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDP 1426
+ S WAL + L + + +Y FG +L R+R SF +++ A++D+P
Sbjct: 733 LRKDSSFWALISVVLGFASFIAIPAEYLLFGIAGGKLIERVRTLSFQNIVHQEVAWFDNP 792
Query: 1425 NHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPX 1246
++S+ L RL+ D+ NV+ V D LG ++ + A+ A W++ L + P
Sbjct: 793 SNSSGALGTRLSVDALNVRRLVGDNLGLIVQSTAALITGFVIAFTADWRLALIITCVIPL 852
Query: 1245 XXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKI 1066
+E +E++++ A +A+ ++RT+ + E ++++ ++ + +
Sbjct: 853 VGAQGYAQVKFLKGFSEEAKEMYEDASQVATDAVGSIRTIASFCAEKRVVTTYNKKCEAL 912
Query: 1065 HKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANM 886
K + I+ G G S Y++ F G + + D + V L + A
Sbjct: 913 RKQGIRSGIVGGLGFGFSFLVLYLTYALCFYVGAQFVRQGKTTFADVFKVFFALVLAAVG 972
Query: 885 AGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGK--KNIEKGEIIGENVQFHYDQ 712
A+A + KA +A +F + + + S+ +G +N+ G+I NV F Y
Sbjct: 973 VSQASALASNATKARDSAISVFSILDRKSKIDTSNDEGLVLENVT-GDIHFSNVSFKYPS 1031
Query: 711 RPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINL 532
RPD I + L + KT+ALVG SG GKSTII+LLERFY G + +D ++ + +
Sbjct: 1032 RPDVQIFSDFTLHIPSRKTIALVGESGSGKSTIIALLERFYDPDSGIISVDGVEIKSLRI 1091
Query: 531 NHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDT 352
+ LR + LV QEP LFN +IR N+ YG V + E+ + ANA F+ PQG DT
Sbjct: 1092 SWLRDQMGLVGQEPVLFNDTIRANITYGKHGEVTEEEVTAVAKAANAHEFISSLPQGYDT 1151
Query: 351 LVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLST 172
LVGE+G QLSGGQKQR+AIARAI+++PK+LLLDEATSALD++SE++VQ+ALD +T
Sbjct: 1152 LVGEKGVQLSGGQKQRVAIARAIIKDPKILLLDEATSALDAESERIVQDALDRVMVSRTT 1211
Query: 171 VVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLR-KRSIYWRLVQ 37
+VVAHRLST+ AD IAVLK GK+AE+G HE L+ K +Y LV+
Sbjct: 1212 IVVAHRLSTIKGADMIAVLKEGKIAEKGKHEALMGIKDGVYASLVE 1257
>gi|50750485|ref|XP_422016.1| PREDICTED: similar to liver bile salt
export pump [Gallus gallus]
Length = 1371
Score = 642 bits (1656), Expect = 0.0
Identities = 394/1107 (35%), Positives = 600/1107 (53%), Gaps = 47/1107 (4%)
Frame = -1
Query: 3219 VSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGI 3040
VS S ++ + E +++A+ I +T F G L F + W+L I S I
Sbjct: 283 VSAPSASAGAQGDVNKINEAIADQVAIFIQRLTTFVCGFLLGFISGWKLTLVIIAVSPLI 342
Query: 3039 AFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGE 2860
+ V K TG++ YA AG++A + L + +TV + G+K E+ERY + L +
Sbjct: 343 GVGAAVYGLAVAKLTGRELKAYAKAGAVADEVLSSIRTVAAFGGEKKEVERYDKNLVYAQ 402
Query: 2859 KYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMI--------------YSGTLETAV- 2725
+GIR+ ++ + G +F + + G+ ++ + G L A+
Sbjct: 403 HWGIRKGIIMGLFSGYMWFVIFLCYALAFWYGSKLVLEEDEYSPGTLLQVFFGVLVGALN 462
Query: 2724 ------------------------VVRDDNVIEKDETDYDVEVEVNGNISFKNVKFSYPT 2617
+ R + E Y ++ +V G I F NV F YP+
Sbjct: 463 LGQASPCLEAFATGRGAAANIFETIDRKPTIDCMSEEGYKLD-KVRGEIEFHNVTFHYPS 521
Query: 2616 RPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNI 2437
RPD ++L IS ++ GE A VGASG+GKST++QL+ +Y+ G I +DG D+ +NI
Sbjct: 522 RPDVKILDNISMVIKTGETTAFVGASGAGKSTIIQLIQRFYDPTDGMITLDGHDIRSLNI 581
Query: 2436 KRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKTI 2257
+ LR IGVV QEPVLF TTI ENIR+G + ++ ++ A ++ANAY F+ P+ T
Sbjct: 582 QWLRAQIGVVEQEPVLFATTIAENIRYGRDDATMEDVIRAAKQANAYKFIMDLPQQFDTH 641
Query: 2256 VGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTI 2077
VGE G+Q+SGGQKQRIAIAR LVRNPKILLLD ATSALDNESE +VQ+AL+ A GRT I
Sbjct: 642 VGEGGSQMSGGQKQRIAIARALVRNPKILLLDMATSALDNESEAIVQEALQKAHLGRTAI 701
Query: 2076 VVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLESHDDHEELPPL 1897
+AHRLS ++ A II + G VE G H+EL+ ++GVY LV Q
Sbjct: 702 SIAHRLSAVKAADVIIGFEHGRAVERGTHEELLKRKGVYFMLVTLQ-------------- 747
Query: 1896 AARQLSQELSPLHSYAIQRSTSNDAGVHDDDMERILDELSKEGAKKSNLREIVKQCRPDY 1717
S+ S L + A + S N V + ++E++ + + G+ +++LR ++Q
Sbjct: 748 -----SKGDSTL-TRAAKESAENK--VVEPNLEKV--QSFRRGSYRASLRASLRQRSRSQ 797
Query: 1716 CFLFI-----AVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYYS-HLWALSFMFLAV 1555
+ ++ G + V + + + F+++ E+ + L F+ + +
Sbjct: 798 LSNVVPDPPLSIAGDQAESVYLKSYEEDDGQAKKTFSILDEEKQKVQINGVCLLFVLVGI 857
Query: 1554 FRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSN 1375
T + Q Y F K E L+ RLR F ML ++DD +S L+ RL TD+S
Sbjct: 858 VSFFTQFLQGYNFAKSGELLTRRLRKIGFQAMLGQDVGWFDDRRNSPGALTTRLATDASQ 917
Query: 1374 VKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQ 1195
V+ A ++G ++ + I +AI A + WK++L ++ F P
Sbjct: 918 VQGATGSQIGMMVNSFTNIGVAIIIAFYFSWKLSLVIMCFLPFLALSGAVQAKMLTGFAA 977
Query: 1194 EDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGL 1015
+D A E + + + EAL N+RTV + E K + ++L +++ K+A + G G
Sbjct: 978 QDKKALEATGQISSEALSNIRTVAGIGKEKKFIDAFEKNLDMPYRAAIKKANVYGICFGF 1037
Query: 1014 SLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHA 835
+ S SVS+++G +L + + + V+ + + G A++Y P+Y KA +
Sbjct: 1038 AQSIVFIANSVSYRYGGFLVQTEGLHYSFVFRVISAIVTSGTALGRASSYTPNYAKAKTS 1097
Query: 834 AGLIFHLFTYPATMPFSSSDGKKNIE-KGEIIGENVQFHYDQRPDRMILNGVNLKVDPGK 658
A +F L + S +G+K + KG I N +F Y RPD +L G+++ V PG+
Sbjct: 1098 AARLFQLIDRLPKISVYSKEGEKWDDFKGSIEFLNCKFTYPSRPDIQVLKGLSVAVKPGQ 1157
Query: 657 TLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFN 478
TLA VG SGCGKST + LLERFY +G V ID + + +N+ LRS + +VSQEP LF+
Sbjct: 1158 TLAFVGSSGCGKSTSVQLLERFYDPEEGSVLIDGHDTKKVNVQFLRSKIGVVSQEPVLFD 1217
Query: 477 CSIRENLLYGL-TRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRI 301
CSI +N+ YG T+ ++ +A + A +FV P+ +T VG +G+QLS GQKQRI
Sbjct: 1218 CSIADNIKYGSNTKDTTMEKVIEAAKKAQLHDFVMSLPEKYETNVGAQGSQLSRGQKQRI 1277
Query: 300 AIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIA 121
AIARAI+R+PK+LLLDEATSALD++SEK VQ ALD A E + +V+AHRLST+ NAD IA
Sbjct: 1278 AIARAIIRDPKILLLDEATSALDTESEKTVQAALDKAREGRTCIVIAHRLSTIENADIIA 1337
Query: 120 VLKNGKVAEQGTHEELLRKRSIYWRLV 40
V+ G + E+GTH+EL+ Y++LV
Sbjct: 1338 VMSQGIIIERGTHDELMAMEGAYYKLV 1364
Score = 296 bits (758), Expect = 2e-78
Identities = 192/526 (36%), Positives = 280/526 (52%), Gaps = 41/526 (7%)
Frame = -1
Query: 3402 EEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQYFD 3223
E+ + +N V F L G F LQ G+ T R+RK +L +D +FD
Sbjct: 839 EKQKVQINGVCLLFVLVGIVSFFTQFLQGYNFAKSGELLTRRLRKIGFQAMLGQDVGWFD 898
Query: 3222 SV--STGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFS 3049
S G L+T L + + + +I +++ T+ + +AFY W+L+ + F
Sbjct: 899 DRRNSPGALTTRLATDASQVQGATGSQIGMMVNSFTNIGVAIIIAFYFSWKLSLVIMCFL 958
Query: 3048 LGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELK 2869
+A SG + + + + G I+ + L +TV + +K I+ + + L
Sbjct: 959 PFLALSGAVQAKMLTGFAAQDKKALEATGQISSEALSNIRTVAGIGKEKKFIDAFEKNLD 1018
Query: 2868 AGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYSGTLETAVVVRDDNVIEKDE 2689
+ I++A +Y I G N+V G ++ + L + V R + I
Sbjct: 1019 MPYRAAIKKANVYGICFGFAQSIVFIANSVSYRYGGFLVQTEGLHYSFVFRVISAIVTSG 1078
Query: 2688 TD---------------------------------YDVEVE----VNGNISFKNVKFSYP 2620
T Y E E G+I F N KF+YP
Sbjct: 1079 TALGRASSYTPNYAKAKTSAARLFQLIDRLPKISVYSKEGEKWDDFKGSIEFLNCKFTYP 1138
Query: 2619 TRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMN 2440
+RPD QVLKG+S V+ G+ +A VG+SG GKST VQLL +Y+ + G++ IDG D +N
Sbjct: 1139 SRPDIQVLKGLSVAVKPGQTLAFVGSSGCGKSTSVQLLERFYDPEEGSVLIDGHDTKKVN 1198
Query: 2439 IKRLRRVIGVVSQEPVLFNTTIEENIRFGN--PNVSLPEIYGALRKANAYDFVCSFPKGI 2266
++ LR IGVVSQEPVLF+ +I +NI++G+ + ++ ++ A +KA +DFV S P+
Sbjct: 1199 VQFLRSKIGVVSQEPVLFDCSIADNIKYGSNTKDTTMEKVIEAAKKAQLHDFVMSLPEKY 1258
Query: 2265 KTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGR 2086
+T VG +G+QLS GQKQRIAIAR ++R+PKILLLDEATSALD ESE+ VQ AL+ A +GR
Sbjct: 1259 ETNVGAQGSQLSRGQKQRIAIARAIIRDPKILLLDEATSALDTESEKTVQAALDKAREGR 1318
Query: 2085 TTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLV 1948
T IV+AHRLSTI NA I VM +G I+E G HDEL+A G Y LV
Sbjct: 1319 TCIVIAHRLSTIENADIIAVMSQGIIIERGTHDELMAMEGAYYKLV 1364
Score = 275 bits (702), Expect = 8e-72
Identities = 170/493 (34%), Positives = 258/493 (51%), Gaps = 5/493 (1%)
Frame = -1
Query: 1494 STRLRI---KSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVV 1324
S RL + + S +L+ C P+ SA D + + A+ D++ I +
Sbjct: 261 SARLHLVLYNAISVILAASCCDVSAPSASAGAQG-----DVNKINEAIADQVAIFIQRLT 315
Query: 1323 AISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEAL 1144
+ WK+TL ++ P + A+ + A E L
Sbjct: 316 TFVCGFLLGFISGWKLTLVIIAVSPLIGVGAAVYGLAVAKLTGRELKAYAKAGAVADEVL 375
Query: 1143 ENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGT 964
++RTV A E K + ++L ++ II G +G Y+++F +G+
Sbjct: 376 SSIRTVAAFGGEKKEVERYDKNLVYAQHWGIRKGIIMGLFSGYMWFVIFLCYALAFWYGS 435
Query: 963 YLALRK-EVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPF 787
L L + E +P V + + A G A+ L + AA IF T+
Sbjct: 436 KLVLEEDEYSPGTLLQVFFGVLVGALNLGQASPCLEAFATGRGAAANIFETIDRKPTIDC 495
Query: 786 SSSDGKK-NIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTII 610
S +G K + +GEI NV FHY RPD IL+ +++ + G+T A VG SG GKSTII
Sbjct: 496 MSEEGYKLDKVRGEIEFHNVTFHYPSRPDVKILDNISMVIKTGETTAFVGASGAGKSTII 555
Query: 609 SLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVP 430
L++RFY DG + +D ++ +N+ LR+ + +V QEP LF +I EN+ YG +
Sbjct: 556 QLIQRFYDPTDGMITLDGHDIRSLNIQWLRAQIGVVEQEPVLFATTIAENIRYGRDDATM 615
Query: 429 QLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDE 250
+ ++ +A + ANA+ F+ PQ DT VGE G+Q+SGGQKQRIAIARA++RNPK+LLLD
Sbjct: 616 E-DVIRAAKQANAYKFIMDLPQQFDTHVGEGGSQMSGGQKQRIAIARALVRNPKILLLDM 674
Query: 249 ATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELL 70
ATSALD++SE +VQ AL A + + +AHRLS V AD I ++G+ E+GTHEELL
Sbjct: 675 ATSALDNESEAIVQEALQKAHLGRTAISIAHRLSAVKAADVIIGFEHGRAVERGTHEELL 734
Query: 69 RKRSIYWRLVQKQ 31
+++ +Y+ LV Q
Sbjct: 735 KRKGVYFMLVTLQ 747
>gi|9294577|dbj|BAB02858.1| multidrug resistance p-glycoprotein; ABC
transporter-like protein [Arabidopsis thaliana]
Length = 1262
Score = 641 bits (1654), Expect = 0.0
Identities = 414/1261 (32%), Positives = 672/1261 (52%), Gaps = 52/1261 (4%)
Frame = -1
Query: 3657 FSTPLLPQSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEV 3478
FS P + + KK + +R +F ++ + L LG++ ++ GF P + +
Sbjct: 20 FSKPKVSKRRRKKIMKSFGSVRSIFMHANSVDLVLMGLGLIGAVGDGFITPIIFF----- 74
Query: 3477 SQVLVTITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYV 3298
IT + N D + +K + M V ++ G A + ++
Sbjct: 75 ------ITGLLLNDIGDSSFGDKTF--MHAIMKNAVALLYVAG-ASLVICFVEGYCWTRT 125
Query: 3297 GDNTTYRVRKQYISRLLKKDAQYFDS--VSTGHLSTVLNDNLERFREVFNEKIALIIAFV 3124
G+ R+R++Y+ +L++D YFD ST + T ++ + ++V +EK+ +
Sbjct: 126 GERQASRMREKYLRAVLRQDVGYFDLHVTSTSDVITSVSSDTLVIQDVLSEKLPNFLMSA 185
Query: 3123 TDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQT 2944
+ F + F WRL G F + + G + ++ + K Y AGSIA Q
Sbjct: 186 SAFVASYIVGFIMLWRLTIVGFPFFILLLIPGLMCGRALINISRKIREEYNEAGSIAEQA 245
Query: 2943 LGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSI---SRGVTYFFCNSL----N 2785
+ +TV + ++ I +++ L+ K G+R+ + I S GVTY + +
Sbjct: 246 ISLVRTVYAFGSERKMISKFSAALEGSVKLGLRQGIAKGIAIGSNGVTYAIWGFMTWYGS 305
Query: 2784 TVVLYVGAT----------MIYSGT----------LETAVVVRDDNVIEKDETDYDVEVE 2665
+V+Y GA + Y GT + VV + +IE + D++ +
Sbjct: 306 RMVMYHGAKGGTIFAVIICITYGGTSLGRGLSNLKYFSEAVVAGERIIEVIKRVPDIDSD 365
Query: 2664 ---------VNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQ 2512
+ G + FK+VKF Y +RP+ + + + +G+ +ALVG SGSGKSTV+
Sbjct: 366 NPRGQVLENIKGEVQFKHVKFMYSSRPETPIFDDLCLRIPSGKSVALVGGSGSGKSTVIS 425
Query: 2511 LLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLP 2332
LL +Y+ G I IDG+ + + +K LR +G+VSQEP LF T+IEENI FG + S
Sbjct: 426 LLQRFYDPIVGEILIDGVSIKKLQVKWLRSQMGLVSQEPALFATSIEENILFGKEDASFD 485
Query: 2331 EIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEAT 2152
E+ A + +NA+DF+ FP G KT VGERG Q+SGGQKQRI+IAR ++++P +LLLDEAT
Sbjct: 486 EVVEAAKSSNAHDFISQFPLGYKTQVGERGVQMSGGQKQRISIARAIIKSPTLLLLDEAT 545
Query: 2151 SALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAK 1972
SALD+ESE+VVQ+AL+NA+ GRTTIV+AHRLSTIRN I V + G+IVE G+H+EL+
Sbjct: 546 SALDSESERVVQEALDNATIGRTTIVIAHRLSTIRNVDVICVFKNGQIVETGSHEELMEN 605
Query: 1971 -RGVYNDLVQAQLLESHDDHEELPPLAARQ-----LSQELSPLHSYAIQRSTSNDAGVHD 1810
G Y LV+ Q++E+ + ++ + ++ R+ ++++ +IQ +S A
Sbjct: 606 VDGQYTSLVRLQIMENEESNDNV-SVSMREGQFSNFNKDVKYSSRLSIQSRSSLFATSSI 664
Query: 1809 DDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQL---IVR 1639
D + + K+ KK + + ++ +P++ + + G +PI A +V
Sbjct: 665 D--TNLAGSIPKD--KKPSFKRLMAMNKPEWKHALYGCLSAVLYGALHPIYAYASGSMVS 720
Query: 1638 TYEGFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHM 1459
Y F ++M + ++ L F+ LAV L Q Y F + E L+ R+R S +
Sbjct: 721 VY--FLTSHDEMKEKTRIYVLLFVGLAVLCFLISIIQQYSFAYMGEYLTKRIRENILSKL 778
Query: 1458 LSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWK 1279
L+ +++D+ +S+ + +RL D++ V++ V +R+ ++ T+ A+S+A T WK
Sbjct: 779 LTFEVSWFDEDENSSGSICSRLAKDANVVRSLVGERVSLLVQTISAVSVACTLGLAISWK 838
Query: 1278 MTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKI 1099
+++ ++ P ++ A + S++ A EA+ N+RT+ A + +++I
Sbjct: 839 LSIVMIAIQPVVVGCFYTQRIVLKSISKKAIKAQDESSKLAAEAVSNIRTITAFSSQERI 898
Query: 1098 MSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYL 919
+ L+ + + +++ + G S S ++++ +G L + ++ +
Sbjct: 899 LKLLKMVQEGPQRENIRQSWLAGIVLATSRSLMTCTSALNYWYGARLIIDGKITSKAFFE 958
Query: 918 VLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDG--KKNIEKGEI 745
+ + T + A A D K A G +F + + DG +NI KG+I
Sbjct: 959 LFILFVSTGRVIADAGAMTMDLAKGSDAVGSVFAVLDRYTNIEPEKPDGFVPQNI-KGQI 1017
Query: 744 IGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVK 565
NV F Y RPD +I ++ +D GK+ A+VGPSG GKSTII L+ERFY + G VK
Sbjct: 1018 KFVNVDFAYPTRPDVIIFKNFSIDIDEGKSTAIVGPSGSGKSTIIGLIERFYDPLKGIVK 1077
Query: 564 IDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLY-GLTRSVPQLELEKALQTANAF 388
ID ++ +L LR ++ LVSQEP LF +IREN++Y G + + + E+ +A + ANA
Sbjct: 1078 IDGRDIRSYHLRSLRQHIGLVSQEPILFAGTIRENIMYGGASDKIDESEIIEAAKAANAH 1137
Query: 387 NFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQ 208
+F+ G DT G+RG QLSGGQKQRIAIARA+L+NP VLLLDEATSALD+ SE++VQ
Sbjct: 1138 DFIVTLSDGYDTYCGDRGVQLSGGQKQRIAIARAVLKNPSVLLLDEATSALDNQSERMVQ 1197
Query: 207 NALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRK--RSIYWRLVQK 34
+AL ++VV+AHRLST+ N D+I VL GKV E GTH LL K +Y+ LV
Sbjct: 1198 DALGRLMVGRTSVVIAHRLSTIQNCDTITVLDKGKVVECGTHSSLLAKGPTGVYFSLVSL 1257
Query: 33 Q 31
Q
Sbjct: 1258 Q 1258
>gi|422286|pir||S30328 multidrug resistance protein 2 - Entamoeba
histolytica
gi|158973|gb|AAA29113.1| P-glycoprotein-2
Length = 1310
Score = 641 bits (1654), Expect = 0.0
Identities = 421/1289 (32%), Positives = 659/1289 (50%), Gaps = 86/1289 (6%)
Frame = -1
Query: 3639 PQSDE-----KKPSQICSF-IRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEV 3478
P DE KKP S +R +++ ++ + L +G+ S+ G P G++
Sbjct: 19 PDPDELARKNKKPDDSGSVTVRQLYRYANWLDLILLAVGIFGSVGCGVLTPCQMLVMGDM 78
Query: 3477 SQVLVT--ITNAINNKTI--DPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAI 3310
T + A N+ DP E + + + L + I + + +
Sbjct: 79 VDTFNTNDLMKAFPNQEAMYDPKYYIPFNHEVTKTVADTINDLVLKMVCFAIGSGVGSFL 138
Query: 3309 MKY----VGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIA 3142
M + + + +R Y LL++DA ++D +G L++ + ++++ ++ ++K
Sbjct: 139 MTFCFFVMSERQGINIRMLYFRALLRQDAGWYDFHESGELTSRIASDVQQIQDGMSQKFG 198
Query: 3141 LIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAG 2962
+I T F G A+ F DW L + S I S + + K T NAG
Sbjct: 199 IIFQTTTSFIAGYAIGFAKDWDLTLVIMSMSPFIVLSMTLLAVFATKFTVLGEESLGNAG 258
Query: 2961 SIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSL-- 2788
+IA T+G +TV SL + E Y E+++ ++Y + + L + G FF
Sbjct: 259 AIAEATIGNMRTVHSLGQEHEFCEMYNEKIRVVDRYNVLKGLTVGLGLGAVMFFIMGAFS 318
Query: 2787 ----------------------NTVVLYVGATMIYSGTLETAVVVRD------------- 2713
+ +++++ + G A+ +
Sbjct: 319 LGSWYASVVLRGKGGKKNVTAGDVMIVFICVLIATQGLSIIAIPLNIFATAKASAYRIYQ 378
Query: 2712 --DNVIEKD--ETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVG 2545
D + + D T + E NGNI+ ++V+F YPTRP Q+L G+ +++ G+ +ALVG
Sbjct: 379 TIDRIPDIDCRSTAGECPTECNGNITLEDVQFRYPTRPTKQILGGLDLEIKKGQTVALVG 438
Query: 2544 ASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEEN 2365
ASG GKST +QL+ Y+ G++ +DG DL D+NIK LR IG+V QEP+LF TI EN
Sbjct: 439 ASGCGKSTTIQLVQRNYDPVGGSVKLDGKDLRDLNIKWLRNQIGLVGQEPILFACTIREN 498
Query: 2364 IRFGNPNVSLP---EIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIART 2194
I G + P E+ + ANA++F+ P+G T+VGE+G LSGGQKQRIAIAR
Sbjct: 499 IMLGARDGETPTEEEMIECAKMANAHEFISHLPEGYDTMVGEKGAALSGGQKQRIAIARA 558
Query: 2193 LVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKG 2014
L+R P ILLLDEATSALD +SE++VQ+ALE ASQGRTTIVVAHRL+T+RNAS+I V +G
Sbjct: 559 LIRKPTILLLDEATSALDTQSEKIVQQALEKASQGRTTIVVAHRLTTVRNASRICVFHQG 618
Query: 2013 EIVEVGNHDELIAKRGVYNDLVQAQLLESHDDHEELPPLAARQLSQELSPLHSYAIQRST 1834
EI+E G H EL+ +G Y LV+ Q +E D E + + QE + I +
Sbjct: 619 EIIEQGTHQELMDLKGTYYGLVKRQSMEEEVDQETVENDLKKIREQENK--EAEEINQHK 676
Query: 1833 SNDAGVHDDDMERILDELSKEGAKKSN------LREIVKQCRPDYCFLFIAVFGSAIQGV 1672
+ D D ++++ +E + E K + LR I+ R ++ G G
Sbjct: 677 NTDTNEDPDIVQKLENEYNSEMKKLKHSNRFVLLRVILDNFRHEWFLSTFGFIGGIGGGA 736
Query: 1671 SYPILAQLIVRTYEGFAMIGEDMLYYSHLWALS-----FMFLAVFRPLTLYCQYYYFGKV 1507
+P IV I D L + + + V L+ + F
Sbjct: 737 IFPFFTLKIVDLIMCLLSINSDTLTDDQKDTIKNICIIVVVIGVASFLSFFMYIGLFLSA 796
Query: 1506 SEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTV 1327
++ R+R + ++ +++D + L+ RL +D + ++ +R+G VI +
Sbjct: 797 GFKMIGRVRKDMYHSIMHQNISWFDRKENMVGSLTTRLASDPTTLQGISGERVGNVIHII 856
Query: 1326 VAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEA 1147
I A+ A Y WK++L V+ P A+E S T +EA
Sbjct: 857 STIGFALGIAFYYDWKVSLAVMAVSPVLIVVVFINGKLNSLEACPAQAAYEKSGITLVEA 916
Query: 1146 LENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFG 967
+E+VRTV++L E+ + + L++ +K A + L+ + F G
Sbjct: 917 VESVRTVQSLTREEHFYEVFKDALREPKIGIYKWAPLLSIFMCLTTLLTQVMNPYGFYIG 976
Query: 966 TYLALRKE--VAPMDTYLV------------LMTLSMTANMAGSAAAYLPDYKKAVHAAG 829
TYL +K P+ +++ +M + A G+ +PD KAV AA
Sbjct: 977 TYLIKKKSNYDLPVPDFMIEFSDRFEEMQKAIMAVIFAAQAVGNLGNIVPDIGKAVRAAK 1036
Query: 828 LIFHLFTYPATMPFSSSDGKK-NIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTL 652
+ + T+ S +G+ N KGEI +++ F Y RPD +L G++ KV+ GKT+
Sbjct: 1037 NTYDVIDRKPTIDCYSEEGETFNDVKGEIEFKDICFRYPTRPDNSVLKGISFKVEQGKTV 1096
Query: 651 ALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCS 472
ALVG SGCGKST + L+ERFY G+V +D N++D+N++ LRS + +V QEP LF S
Sbjct: 1097 ALVGASGCGKSTSVQLIERFYDPTHGDVLLDGHNIKDLNIHFLRSQIGMVGQEPVLFAES 1156
Query: 471 IRENLLYGLTR--SVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIA 298
+ +N+ G+ + V ++ A + ANA +F+ P+G +T+VG+RGAQ+SGGQKQRIA
Sbjct: 1157 VMDNIRRGVPKGVEVSNEQIYAAAKMANAHDFISAMPEGYNTMVGDRGAQISGGQKQRIA 1216
Query: 297 IARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAV 118
IARA++RNPKVLLLDEATSALDS+SEK+VQ+ALD A++ +T+V+AHRLST+ NAD I V
Sbjct: 1217 IARALIRNPKVLLLDEATSALDSESEKIVQDALDKAAKGRTTIVIAHRLSTIQNADQICV 1276
Query: 117 LKNGKVAEQGTHEELLRKRSIYWRLVQKQ 31
+ G++AE+GTH+ELL + Y+ L +Q
Sbjct: 1277 IMRGRIAERGTHQELLDLKGFYYTLAMQQ 1305
Score = 294 bits (752), Expect = 1e-77
Identities = 177/536 (33%), Positives = 283/536 (52%), Gaps = 11/536 (2%)
Frame = -1
Query: 1578 LSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSN 1399
L + A+ + + + F +SE+ +R+ F +L +YD H + L++
Sbjct: 123 LKMVCFAIGSGVGSFLMTFCFFVMSERQGINIRMLYFRALLRQDAGWYDF--HESGELTS 180
Query: 1398 RLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXX 1219
R+ +D ++ + + G + T + W +TL ++ P
Sbjct: 181 RIASDVQQIQDGMSQKFGIIFQTTTSFIAGYAIGFAKDWDLTLVIMSMSPFIVLSMTLLA 240
Query: 1218 XXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAI 1039
+ N+ A + N+RTV +L E + + +E ++ + + +
Sbjct: 241 VFATKFTVLGEESLGNAGAIAEATIGNMRTVHSLGQEHEFCEMYNEKIRVVDRYN----V 296
Query: 1038 IQGAANGLSLSCFLFVYSVSFKFGTYLAL--------RKEVAPMDTYLVLMTLSMTANMA 883
++G GL L +F +F G++ A +K V D +V + + +
Sbjct: 297 LKGLTVGLGLGAVMFFIMGAFSLGSWYASVVLRGKGGKKNVTAGDVMIVFICVLIATQGL 356
Query: 882 GSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIE-KGEIIGENVQFHYDQRP 706
A L + A +A I+ + S+ G+ E G I E+VQF Y RP
Sbjct: 357 SIIAIPLNIFATAKASAYRIYQTIDRIPDIDCRSTAGECPTECNGNITLEDVQFRYPTRP 416
Query: 705 DRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNH 526
+ IL G++L++ G+T+ALVG SGCGKST I L++R Y V G VK+D +++ D+N+
Sbjct: 417 TKQILGGLDLEIKKGQTVALVGASGCGKSTTIQLVQRNYDPVGGSVKLDGKDLRDLNIKW 476
Query: 525 LRSNLALVSQEPTLFNCSIRENLLYGLT--RSVPQLELEKALQTANAFNFVFQFPQGLDT 352
LR+ + LV QEP LF C+IREN++ G + + E+ + + ANA F+ P+G DT
Sbjct: 477 LRNQIGLVGQEPILFACTIRENIMLGARDGETPTEEEMIECAKMANAHEFISHLPEGYDT 536
Query: 351 LVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLST 172
+VGE+GA LSGGQKQRIAIARA++R P +LLLDEATSALD+ SEK+VQ AL+ AS+ +T
Sbjct: 537 MVGEKGAALSGGQKQRIAIARALIRKPTILLLDEATSALDTQSEKIVQQALEKASQGRTT 596
Query: 171 VVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQVETPSD 4
+VVAHRL+TV NA I V G++ EQGTH+EL+ + Y+ LV++Q ++ E +
Sbjct: 597 IVVAHRLTTVRNASRICVFHQGEIIEQGTHQELMDLKGTYYGLVKRQSMEEEVDQE 652
>gi|25297456|pir||F86155 probable ABC transporter [imported] -
Arabidopsis thaliana
gi|9972377|gb|AAG10627.1| Putative ABC transporter [Arabidopsis
thaliana]
Length = 1229
Score = 640 bits (1652), Expect = 0.0
Identities = 415/1239 (33%), Positives = 640/1239 (51%), Gaps = 68/1239 (5%)
Frame = -1
Query: 3549 LLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQVV 3370
+ G L ++ G C P M+ FG++ + + NNK I +++V
Sbjct: 2 ICGSLGAIGNGVCLPLMTLLFGDL---IDSFGKNQNNKDIVDV------------VSKVC 46
Query: 3369 FHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQYFD-SVSTGHLSTV 3193
F G A LQ A G+ ++R Y+ +L++D +FD +TG +
Sbjct: 47 LKFVYLGLGRLGAAFLQVACWMITGERQAAKIRSNYLKTILRQDIGFFDVETNTGEVVGR 106
Query: 3192 LNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSA 3013
++ + ++ EK+ I V+ F G ALAF W L + +A +G +
Sbjct: 107 MSGDTVHIQDAMGEKVGKFIQLVSTFVGGFALAFAKGWLLTLVMLTSIPFLAMAGAAMAL 166
Query: 3012 GVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALM 2833
V + + + YA A ++ QT+G+ +TV S G+K I Y + + + K I++
Sbjct: 167 LVTRASSRGQAAYAKAATVVEQTIGSIRTVASFTGEKQAINSYKKYITSAYKSSIQQGFS 226
Query: 2832 YSISRGVTYFFCNSLNTVVLYVGATMI----YSGTLETAVVV------------------ 2719
+ GV + S + ++ G MI Y+G V++
Sbjct: 227 TGLGLGVMIYVFFSSYALAIWFGGKMILEKGYTGGSVINVIIIVVAGSMSLGQTSPCVTA 286
Query: 2718 ---------------RDDNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGIS 2584
+ +I+ + + V ++ G+I K+V FSYP RPD ++ G S
Sbjct: 287 FAAGQAAAYKMFETIKRKPLIDAYDVNGKVLGDIRGDIELKDVHFSYPARPDEEIFDGFS 346
Query: 2583 FDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVS 2404
+ +G ALVG SGSGKSTV+ L+ +Y+ +G + IDG++L + +K +R IG+V
Sbjct: 347 LFIPSGATAALVGESGSGKSTVINLIERFYDPKAGEVLIDGINLKEFQLKWIRSKIGLVC 406
Query: 2403 QEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGG 2224
QEPVLF+++I ENI +G N +L EI A ANA F+ + P+G+ T VGE GTQLSGG
Sbjct: 407 QEPVLFSSSIMENIAYGKENATLQEIKVATELANAAKFINNLPQGLDTKVGEHGTQLSGG 466
Query: 2223 QKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRN 2044
QKQRIAIAR ++++P++LLLDEATSALD ESE+VVQ+AL+ RTT+VVAHRLST+RN
Sbjct: 467 QKQRIAIARAILKDPRVLLLDEATSALDTESERVVQEALDRVMVNRTTVVVAHRLSTVRN 526
Query: 2043 ASKIIVMQKGEIVEVGNHDELIAKR-GVYNDLVQAQLLESHDDHEELPPLAARQLSQELS 1867
A I V+ G++VE G+H EL+ G Y+ L++ Q E + H+ P A S S
Sbjct: 527 ADMIAVIHSGKMVEKGSHSELLKDSVGAYSQLIRCQ--EINKGHDAKPSDMASGSSFRNS 584
Query: 1866 PLH----SYAIQRSTS---NDAGVHDDDM-------------ERILDE----LSKEGAKK 1759
L+ I TS N + H ++ +R+ E S+E +K
Sbjct: 585 NLNISREGSVISGGTSSFGNSSRHHSLNVLGLFAGLDLGSGSQRVGQEETGTTSQEPLRK 644
Query: 1758 SNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYYSHLWA 1579
+L I +P+ L + +AI G +P+ LI R E F + + S WA
Sbjct: 645 VSLTRIAALNKPEIPVLLLGTVVAAINGAIFPLFGILISRVIEAFFKPADQLKKDSRFWA 704
Query: 1578 LSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSN 1399
+ F+ L V + Q Y F +L R++ F + + +++D+P +S+ +
Sbjct: 705 IIFVALGVTSLIVSPSQMYLFAVAGGKLIRRIQSMCFEKAVHMEVSWFDEPENSSGTMGA 764
Query: 1398 RLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXX 1219
RL+TD++ ++A V D L + + + + A W++ L +L+ P
Sbjct: 765 RLSTDAALIRALVGDALSLAVQNAASAASGLIIAFTASWELALIILVMLPLIGINGFLQV 824
Query: 1218 XXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAI 1039
+ +E +++ A +A+ ++RTV + E+K+M + ++ + K K+
Sbjct: 825 KFMKGFSADAKSKYEEASQVANDAVGSIRTVASFCAEEKVMQMYNKQCEGPIKDGVKQGF 884
Query: 1038 IQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLP 859
I G G S VY+ SF L + +D + V L+M A ++ + P
Sbjct: 885 ISGLGFGFSFFILFCVYATSFYAAARLVEDGKTTFIDVFQVFFALTMAAIGISQSSTFAP 944
Query: 858 DYKKAVHAAGLIFHLFTYPATMPFSSSDGK--KNIEKGEIIGENVQFHYDQRPDRMILNG 685
D KA AA IF + + + S G +N+ KG+I ++ F Y RP I
Sbjct: 945 DSSKAKVAAASIFAIIDRKSKIDSSDETGTVLENV-KGDIELRHLSFTYPARPGIQIFRD 1003
Query: 684 VNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLAL 505
+ L + GKT+ALVG SG GKST+ISLL+RFY G++ +D ++ + L LR + L
Sbjct: 1004 LCLTIRAGKTVALVGESGSGKSTVISLLQRFYDPDSGQITLDGVELKKLQLKWLRQQMGL 1063
Query: 504 VSQEPTLFNCSIRENLLYGL--TRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGA 331
V QEP LFN +IR N+ YG + + E+ A + ANA F+ QG DT+VGE+G
Sbjct: 1064 VGQEPVLFNDTIRANIAYGKGSEEAATESEIIAAAELANAHKFISSIQQGYDTVVGEKGI 1123
Query: 330 QLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRL 151
QLSGGQKQR+AIARAI++ PK+LLLDEATSALD++SE++VQ+ALD +TVVVAHRL
Sbjct: 1124 QLSGGQKQRVAIARAIVKEPKILLLDEATSALDAESERLVQDALDRVIVNRTTVVVAHRL 1183
Query: 150 STVVNADSIAVLKNGKVAEQGTHEELLR-KRSIYWRLVQ 37
ST+ NAD IA++KNG +AE GTHE L++ +Y LVQ
Sbjct: 1184 STIKNADVIAIVKNGVIAENGTHETLIKIDGGVYASLVQ 1222
Score = 281 bits (720), Expect = 6e-74
Identities = 187/560 (33%), Positives = 291/560 (51%), Gaps = 4/560 (0%)
Frame = -1
Query: 1692 GSAIQGVSYPILAQLIVRTYEGFA--MIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYY 1519
G+ GV P++ L + F +D++ L F++L + R + Q
Sbjct: 7 GAIGNGVCLPLMTLLFGDLIDSFGKNQNNKDIVDVVSKVCLKFVYLGLGRLGAAFLQVAC 66
Query: 1518 FGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCV 1339
+ E+ + ++R +L F+D ++ + R++ D+ +++ A+ +++G
Sbjct: 67 WMITGERQAAKIRSNYLKTILRQDIGFFDVETNTG-EVVGRMSGDTVHIQDAMGEKVGKF 125
Query: 1338 IMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRT 1159
I V A W +TL +L P A A+ +
Sbjct: 126 IQLVSTFVGGFALAFAKGWLLTLVMLTSIPFLAMAGAAMALLVTRASSRGQAAYAKAATV 185
Query: 1158 AIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVS 979
+ + ++RTV + E + ++ +++ +KS ++ G G+ + F Y+++
Sbjct: 186 VEQTIGSIRTVASFTGEKQAINSYKKYITSAYKSSIQQGFSTGLGLGVMIYVFFSSYALA 245
Query: 978 FKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPA 799
FG + L K V++ + + G + + + AA +F
Sbjct: 246 IWFGGKMILEKGYTGGSVINVIIIVVAGSMSLGQTSPCVTAFAAGQAAAYKMFETIKRKP 305
Query: 798 TMPFSSSDGKKNIE-KGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGK 622
+ +GK + +G+I ++V F Y RPD I +G +L + G T ALVG SG GK
Sbjct: 306 LIDAYDVNGKVLGDIRGDIELKDVHFSYPARPDEEIFDGFSLFIPSGATAALVGESGSGK 365
Query: 621 STIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLT 442
ST+I+L+ERFY GEV ID N+++ L +RS + LV QEP LF+ SI EN+ YG
Sbjct: 366 STVINLIERFYDPKAGEVLIDGINLKEFQLKWIRSKIGLVCQEPVLFSSSIMENIAYGKE 425
Query: 441 RSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVL 262
+ Q E++ A + ANA F+ PQGLDT VGE G QLSGGQKQRIAIARAIL++P+VL
Sbjct: 426 NATLQ-EIKVATELANAAKFINNLPQGLDTKVGEHGTQLSGGQKQRIAIARAILKDPRVL 484
Query: 261 LLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTH 82
LLDEATSALD++SE+VVQ ALD +TVVVAHRLSTV NAD IAV+ +GK+ E+G+H
Sbjct: 485 LLDEATSALDTESERVVQEALDRVMVNRTTVVVAHRLSTVRNADMIAVIHSGKMVEKGSH 544
Query: 81 EELLRKR-SIYWRLVQKQGI 25
ELL+ Y +L++ Q I
Sbjct: 545 SELLKDSVGAYSQLIRCQEI 564
Score = 278 bits (711), Expect = 7e-73
Identities = 170/524 (32%), Positives = 264/524 (49%), Gaps = 44/524 (8%)
Frame = -1
Query: 3363 FFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSV--STGHLSTVL 3190
F G I + Q + G R++ + + + +FD S+G + L
Sbjct: 707 FVALGVTSLIVSPSQMYLFAVAGGKLIRRIQSMCFEKAVHMEVSWFDEPENSSGTMGARL 766
Query: 3189 NDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAG 3010
+ + R + + ++L + G +AF W LA + I +GF+
Sbjct: 767 STDAALIRALVGDALSLAVQNAASAASGLIIAFTASWELALIILVMLPLIGINGFLQVKF 826
Query: 3009 VMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMY 2830
+ + + Y A +A +G+ +TV S ++ ++ Y ++ + K G+++ +
Sbjct: 827 MKGFSADAKSKYEEASQVANDAVGSIRTVASFCAEEKVMQMYNKQCEGPIKDGVKQGFIS 886
Query: 2829 SISRGVTYFFCNSLNTVVLYVGATMIYSGTLET--------------------------- 2731
+ G ++F + Y A ++ G
Sbjct: 887 GLGFGFSFFILFCVYATSFYAAARLVEDGKTTFIDVFQVFFALTMAAIGISQSSTFAPDS 946
Query: 2730 -----------AVVVRDDNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGIS 2584
A++ R + DET +E V G+I +++ F+YP RP Q+ + +
Sbjct: 947 SKAKVAAASIFAIIDRKSKIDSSDETGTVLE-NVKGDIELRHLSFTYPARPGIQIFRDLC 1005
Query: 2583 FDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVS 2404
++ G+ +ALVG SGSGKSTV+ LL +Y+ DSG I +DG++L + +K LR+ +G+V
Sbjct: 1006 LTIRAGKTVALVGESGSGKSTVISLLQRFYDPDSGQITLDGVELKKLQLKWLRQQMGLVG 1065
Query: 2403 QEPVLFNTTIEENIRFGNPN---VSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQL 2233
QEPVLFN TI NI +G + + EI A ANA+ F+ S +G T+VGE+G QL
Sbjct: 1066 QEPVLFNDTIRANIAYGKGSEEAATESEIIAAAELANAHKFISSIQQGYDTVVGEKGIQL 1125
Query: 2232 SGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLST 2053
SGGQKQR+AIAR +V+ PKILLLDEATSALD ESE++VQ AL+ RTT+VVAHRLST
Sbjct: 1126 SGGQKQRVAIARAIVKEPKILLLDEATSALDAESERLVQDALDRVIVNRTTVVVAHRLST 1185
Query: 2052 IRNASKIIVMQKGEIVEVGNHDELI-AKRGVYNDLVQAQLLESH 1924
I+NA I +++ G I E G H+ LI GVY LVQ + S+
Sbjct: 1186 IKNADVIAIVKNGVIAENGTHETLIKIDGGVYASLVQLHMTASN 1229
>gi|34913530|ref|NP_918112.1| putative multidrug resistance protein
[Oryza sativa (japonica cultivar-group)]
gi|20146370|dbj|BAB89151.1| putative multidrug resistance protein
[Oryza sativa (japonica cultivar-group)]
gi|27368871|emb|CAD59593.1| MDR-like ABC transporter [Oryza sativa
(japonica cultivar-group)]
Length = 1287
Score = 640 bits (1651), Expect = 0.0
Identities = 419/1256 (33%), Positives = 648/1256 (51%), Gaps = 69/1256 (5%)
Frame = -1
Query: 3597 IRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPAD 3418
+R +F + + L +G ++ G QP M++ FG+V NA + T P
Sbjct: 44 VRRMFAFADGADAALMAVGAAAAVANGMAQPLMTFIFGDV-------INAFGS-TSSPDV 95
Query: 3417 LEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKD 3238
L K + +V+ +F G ++LQ + G+ R+R Y+ +L++D
Sbjct: 96 LAK--------VTKVILNFVYLGIGAGFVSTLQVSCWTITGERQAARIRALYLKAILRQD 147
Query: 3237 AQYFDS-VSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYG 3061
+FD +STG + ++ + ++ EK I ++ F G +AF W LA
Sbjct: 148 IAFFDKEMSTGQVVERMSGDTFLIQDAIGEKSGKCIQLLSTFFGGFIIAFVRGWLLALVL 207
Query: 3060 IFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYT 2881
+ IA +G S + + + + Y +AG+IA QT+GA +TV S NG+K I Y
Sbjct: 208 LSCIPPIAVAGAFVSRLMTRISTRMQEKYGDAGNIAEQTIGAIRTVASFNGEKQAINTYN 267
Query: 2880 EELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMI----YSGTLETAVV--- 2722
+ ++ + ++ ++ + G + ++ G+ +I Y+G + V+
Sbjct: 268 KFIRKAYESTLQEGVVNGLGLGTVMAILFCSYGLAVWYGSKLIVNRGYNGGIVINVLMSV 327
Query: 2721 ------------------------------VRDDNVIEKDETDYDVEVEVNGNISFKNVK 2632
++ I+ +T + ++ G++ K+V
Sbjct: 328 MMGAMSLGQATPSITAFAEGQGAAYRMFKTIKRQPDIDVCDTKGIILEDITGDVELKDVY 387
Query: 2631 FSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDL 2452
FSYPTRP+ V G S + +G +ALVG SGSGKSTV+ L+ +Y+ SG + IDG+D+
Sbjct: 388 FSYPTRPEYLVFNGFSLQIPSGRTMALVGESGSGKSTVISLVERFYDPQSGEVLIDGIDI 447
Query: 2451 NDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPK 2272
MN+ +R I +VSQEPVLF++TI ENI +G + +L EI A+ ANA FV P
Sbjct: 448 RRMNLGWIRGKISLVSQEPVLFSSTIRENIAYGKEDQTLEEIKRAVELANAAKFVDKLPN 507
Query: 2271 GIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQ 2092
G++T+VGERG QLSGGQKQRIAIAR +++NP+ILLLDEATSALD ESE+VVQ AL
Sbjct: 508 GLETMVGERGIQLSGGQKQRIAIARAIIKNPRILLLDEATSALDMESERVVQDALNRVML 567
Query: 2091 GRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAK-RGVYNDLVQ----AQLLES 1927
RTTI+VAHRLST++NA I V+Q+G++VE G+H EL+ K G Y L+Q Q E
Sbjct: 568 ERTTIIVAHRLSTVKNADVISVLQQGKMVEQGSHVELMKKPEGAYAQLIQLQGAQQDAEI 627
Query: 1926 HDDHEEL--------PPLAARQLSQELSPLHSYAIQRSTSNDAGVH-------------- 1813
H+D ++ + + SQ S S + S+ +G H
Sbjct: 628 HNDDTDMIIRSDSGSRSINVKPRSQSTSFRRSIT-KGSSFGHSGRHPIPAPLDFPDPMEF 686
Query: 1812 --DDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVR 1639
D ME D++ + G KK+++ + +P+ L + +A+ G+ +PI LI
Sbjct: 687 KDDLGMEETTDKVPR-GQKKASISRLFYLNKPEAFVLVLGSVTAAMHGLMFPIFGILISS 745
Query: 1638 TYEGFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHM 1459
+ F ++L S WA F+ + + + +Y+ FG +L R+R +F +
Sbjct: 746 AIKMFYEPPSELLKDSRFWASMFVVVGASAFVLIPTEYFLFGLAGGKLVERIRSLTFRSV 805
Query: 1458 LSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWK 1279
+ ++D P HS+ + RL+ D+ NVK V D L + TV + T A + WK
Sbjct: 806 MHQEINWFDKPEHSSGSIGARLSVDALNVKRLVGDNLALNVQTVSTVISGFTIAMVANWK 865
Query: 1278 MTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKI 1099
+ L + + P + + +E +++ A +A+ +RTV + E K+
Sbjct: 866 LALIITVVVPLVGFQAYAQMKFLKGFNKNAKLKYEEASQVATDAVGGIRTVASFCAEQKV 925
Query: 1098 MSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYL 919
+ + + + + ++ G G S F F Y++ F G + + +
Sbjct: 926 IEAYEKKCESPVRQGIREGVVGGLGFGFSFLVFYFTYALCFYVGAKFVHQGVATFPEVFR 985
Query: 918 VLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIE-KGEII 742
V L + + +A D KA +A IF + + + SS +G +G+I
Sbjct: 986 VFFVLVLATSGISRTSAIGADSTKANESAVSIFEILDRKSKIDSSSEEGVVIASVRGDIE 1045
Query: 741 GENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKI 562
NV F+Y RP+ I ++L + GKT+ALVG SG GKST I+LLERFY G++ +
Sbjct: 1046 FHNVCFNYPLRPNIQIFKDLSLCIPSGKTVALVGESGSGKSTAIALLERFYDPDTGKILL 1105
Query: 561 DSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNF 382
D +++ ++ LR + LV+QEP LFN +I N+ YG Q E+ A + ANA F
Sbjct: 1106 DGVDLKTFKVSWLRIQIGLVAQEPVLFNDTIHANIAYGKQEQASQEEIMAAAEAANAHQF 1165
Query: 381 VFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNA 202
+ P G T+VGERG QLSGGQKQR+AIARAI+++PKVLLLDEATSALD++SE+VVQ A
Sbjct: 1166 ISALPDGYSTVVGERGIQLSGGQKQRVAIARAIMKDPKVLLLDEATSALDAESERVVQEA 1225
Query: 201 LDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLR-KRSIYWRLVQ 37
LD +TVVVAHRLST+ AD I VLKNG + E+G H+EL+R K Y LV+
Sbjct: 1226 LDRVMVGRTTVVVAHRLSTIKGADIIGVLKNGAIVEKGGHDELMRIKDGTYASLVE 1281
>gi|22331385|ref|NP_683599.1| P-glycoprotein, putative [Arabidopsis
thaliana]
Length = 1221
Score = 639 bits (1649), Expect = 0.0
Identities = 407/1241 (32%), Positives = 664/1241 (52%), Gaps = 52/1241 (4%)
Frame = -1
Query: 3597 IRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPAD 3418
+R +F ++ + L LG++ ++ GF P + + IT + N D +
Sbjct: 7 VRSIFMHANSVDLVLMGLGLIGAVGDGFITPIIFF-----------ITGLLLNDIGDSSF 55
Query: 3417 LEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKD 3238
+K + H + ++ + ++ +VG+ R+R++Y+ +L++D
Sbjct: 56 GDKTF-----------MHAIMKNAVALLYVAGASLVICFVGERQASRMREKYLRAVLRQD 104
Query: 3237 AQYFDS--VSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASY 3064
YFD ST + T ++ + ++V +EK+ + + F + F WRL
Sbjct: 105 VGYFDLHVTSTSDVITSVSSDTLVIQDVLSEKLPNFLMSASAFVASYIVGFIMLWRLTIV 164
Query: 3063 GIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERY 2884
G F + + G + ++ + K Y AGSIA Q + +TV + ++ I ++
Sbjct: 165 GFPFFILLLIPGLMCGRALINISRKIREEYNEAGSIAEQAISLVRTVYAFGSERKMISKF 224
Query: 2883 TEELKAGEKYGIRRALMYSI---SRGVTYFFCNSL----NTVVLYVGAT----------M 2755
+ L+ K G+R+ + I S GVTY + + +V+Y GA +
Sbjct: 225 SAALEGSVKLGLRQGIAKGIAIGSNGVTYAIWGFMTWYGSRMVMYHGAKGGTIFAVIICI 284
Query: 2754 IYSGT----------LETAVVVRDDNVIEKDETDYDVEVE---------VNGNISFKNVK 2632
Y GT + VV + +IE + D++ + + G + FK+VK
Sbjct: 285 TYGGTSLGRGLSNLKYFSEAVVAGERIIEVIKRVPDIDSDNPRGQVLENIKGEVQFKHVK 344
Query: 2631 FSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDL 2452
F Y +RP+ + + + +G+ +ALVG SGSGKSTV+ LL +Y+ G I IDG+ +
Sbjct: 345 FMYSSRPETPIFDDLCLRIPSGKSVALVGGSGSGKSTVISLLQRFYDPIVGEILIDGVSI 404
Query: 2451 NDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPK 2272
+ +K LR +G+VSQEP LF T+IEENI FG + S E+ A + +NA+DF+ FP
Sbjct: 405 KKLQVKWLRSQMGLVSQEPALFATSIEENILFGKEDASFDEVVEAAKSSNAHDFISQFPL 464
Query: 2271 GIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQ 2092
G KT VGERG Q+SGGQKQRI+IAR ++++P +LLLDEATSALD+ESE+VVQ+AL+NA+
Sbjct: 465 GYKTQVGERGVQMSGGQKQRISIARAIIKSPTLLLLDEATSALDSESERVVQEALDNATI 524
Query: 2091 GRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAK-RGVYNDLVQAQLLESHDDH 1915
GRTTIV+AHRLSTIRN I V + G+IVE G+H+EL+ G Y LV+ Q++E+ + +
Sbjct: 525 GRTTIVIAHRLSTIRNVDVICVFKNGQIVETGSHEELMENVDGQYTSLVRLQIMENEESN 584
Query: 1914 EELPPLAARQ-----LSQELSPLHSYAIQRSTSNDAGVHDDDMERILDELSKEGAKKSNL 1750
+ + ++ R+ ++++ +IQ +S A D + + K+ KK +
Sbjct: 585 DNV-SVSMREGQFSNFNKDVKYSSRLSIQSRSSLFATSSID--TNLAGSIPKD--KKPSF 639
Query: 1749 REIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQL---IVRTYEGFAMIGEDMLYYSHLWA 1579
+ ++ +P++ + + G +PI A +V Y F ++M + ++
Sbjct: 640 KRLMAMNKPEWKHALYGCLSAVLYGALHPIYAYASGSMVSVY--FLTSHDEMKEKTRIYV 697
Query: 1578 LSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSN 1399
L F+ LAV L Q Y F + E L+ R+R S +L+ +++D+ +S+ + +
Sbjct: 698 LLFVGLAVLCFLISIIQQYSFAYMGEYLTKRIRENILSKLLTFEVSWFDEDENSSGSICS 757
Query: 1398 RLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXX 1219
RL D++ V++ V +R+ ++ T+ A+S+A T WK+++ ++ P
Sbjct: 758 RLAKDANVVRSLVGERVSLLVQTISAVSVACTLGLAISWKLSIVMIAIQPVVVGCFYTQR 817
Query: 1218 XXXXXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAI 1039
++ A + S++ A EA+ N+RT+ A + +++I+ L+ + + +++
Sbjct: 818 IVLKSISKKAIKAQDESSKLAAEAVSNIRTITAFSSQERILKLLKMVQEGPQRENIRQSW 877
Query: 1038 IQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLP 859
+ G S S ++++ +G L + ++ + + + T + A A
Sbjct: 878 LAGIVLATSRSLMTCTSALNYWYGARLIIDGKITSKAFFELFILFVSTGRVIADAGAMTM 937
Query: 858 DYKKAVHAAGLIFHLFTYPATMPFSSSDG--KKNIEKGEIIGENVQFHYDQRPDRMILNG 685
D K A G +F + + DG +NI KG+I NV F Y RPD +I
Sbjct: 938 DLAKGSDAVGSVFAVLDRYTNIEPEKPDGFVPQNI-KGQIKFVNVDFAYPTRPDVIIFKN 996
Query: 684 VNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLAL 505
++ +D GK+ A+VGPSG GKSTII L+ERFY + G VKID ++ +L LR ++ L
Sbjct: 997 FSIDIDEGKSTAIVGPSGSGKSTIIGLIERFYDPLKGIVKIDGRDIRSYHLRSLRQHIGL 1056
Query: 504 VSQEPTLFNCSIRENLLY-GLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQ 328
VSQEP LF +IREN++Y G + + + E+ +A + ANA +F+ G DT G+RG Q
Sbjct: 1057 VSQEPILFAGTIRENIMYGGASDKIDESEIIEAAKAANAHDFIVTLSDGYDTYCGDRGVQ 1116
Query: 327 LSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLS 148
LSGGQKQRIAIARA+L+NP VLLLDEATSALD+ SE++VQ+AL ++VV+AHRLS
Sbjct: 1117 LSGGQKQRIAIARAVLKNPSVLLLDEATSALDNQSERMVQDALGRLMVGRTSVVIAHRLS 1176
Query: 147 TVVNADSIAVLKNGKVAEQGTHEELLRK--RSIYWRLVQKQ 31
T+ N D+I VL GKV E GTH LL K +Y+ LV Q
Sbjct: 1177 TIQNCDTITVLDKGKVVECGTHSSLLAKGPTGVYFSLVSLQ 1217
>gi|2673951|gb|AAB88657.1| multidrug resistance protein 1 [Aspergillus
fumigatus]
gi|2673953|gb|AAB88658.1| multidrug resistance protein 1 [Aspergillus
fumigatus]
Length = 1349
Score = 638 bits (1646), Expect = 0.0
Identities = 416/1268 (32%), Positives = 641/1268 (49%), Gaps = 70/1268 (5%)
Frame = -1
Query: 3618 PSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINN 3439
PS SF +++ +S + + L+ + ++ G P + FG ++ I+
Sbjct: 90 PSVKVSFF-TLYRYASRKDILIILVSAICAIAAGAALPLFTILFGSLASAFQGISLGT-- 146
Query: 3438 KTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYI 3259
Y E+ + + V +F G A F+ + Y G++ T ++R+ Y+
Sbjct: 147 ---------MPYHEFYHKLTKNVLYFVYLGIAEFVTVYVSTVGFIYTGEHLTQKIRENYL 197
Query: 3258 SRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDW 3079
+L+++ YFD + G ++T + + ++ +EK+ L + F +A+ W
Sbjct: 198 EAILRQNMAYFDKLGAGEVTTRITADTNLIQDAISEKVGLTLTAFATFVTAFIVAYVKYW 257
Query: 3078 RLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKT 2899
+LA + + S ++K + K Y G++A + + + + + Q
Sbjct: 258 KLALICTSTIVALVMVMGGGSRFIVKYSKKSIESYGAGGTVAEEVISSIRNATAFGTQDK 317
Query: 2898 EIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYSGTLETAVVV 2719
++Y L EK+G+++ ++ + G + S + ++G+ + + V+
Sbjct: 318 LAKQYETHLAEAEKWGVKQQVILGMMIGGMFGIMFSNYGLGFWMGSRFVVGKEVNVGQVL 377
Query: 2718 RD-----------DNVIEKDET----------------------DYDVEVEV----NGNI 2650
NV + Y E +V GNI
Sbjct: 378 TVLMSILIGSFSLGNVAPNGQAFTNGVAAAAKIYSTIDRRSPLDPYSDEGKVLDHFEGNI 437
Query: 2649 SFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIF 2470
F+NVK YP+RP+ V++ +S + G+ ALVG SGSGKSTVV L+ +Y G +
Sbjct: 438 EFRNVKHIYPSRPEVTVMEDVSLSMPAGKTTALVGPSGSGKSTVVGLVERFYLPVGGQVL 497
Query: 2469 IDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPE---------IYGA 2317
+DG D+ +N++ LR+ I +VSQEPVLF+TTI NI G + A
Sbjct: 498 LDGHDIQTLNLRWLRQQISLVSQEPVLFSTTIFRNIEHGLIGTKFEHESKDKIRELVENA 557
Query: 2316 LRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDN 2137
R ANA+DF+ + P+G T VG+RG LSGGQKQRIAIAR +V +PKILLLDEATSALD
Sbjct: 558 ARMANAHDFIMALPEGYDTNVGQRGFLLSGGQKQRIAIARAIVSDPKILLLDEATSALDT 617
Query: 2136 ESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYN 1957
+SE VVQ AL+ A++GRTTIV+AHRLSTI+ A I+ M G+I E G HDEL+ ++G Y
Sbjct: 618 KSEGVVQAALDKAAEGRTTIVIAHRLSTIKTAHNIVAMVGGKIAEQGTHDELVDRKGTYY 677
Query: 1956 DLVQAQLLESHDDHEEL---PPLAARQLSQELSPLHSYAIQRSTSNDA------------ 1822
LV+AQ + + E L + A QE A+ S S DA
Sbjct: 678 KLVEAQRINEEKEAEALEADADMDADDFGQEGVTRIKTAVSSSNSLDAVDEKARLEMKRT 737
Query: 1821 GVHDDDMERILDELSKEGAKKSNLREIVKQC----RPDYCFLFIAVFGSAIQGVSYPILA 1654
G +L + E +K +L +VK RP+ ++ I + S + G P A
Sbjct: 738 GTQKSVSSAVLSKKVPEQFEKYSLWTLVKFIGAFNRPELGYMLIGLTFSFLAGGGQPTQA 797
Query: 1653 QLIVRTYEGFAM---IGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRL 1483
L + ++ + + + ++ W+L F + + + ++L F SE+L R
Sbjct: 798 FLYAKAISTLSLPESMFHKLRHDANFWSLMFFVVGIAQFISLSINGTAFAICSERLIRRA 857
Query: 1482 RIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAIT 1303
R ++F +L +F+D +S L++ L+T++ N+ LG +IMT + A+
Sbjct: 858 RSQAFRSILRQDISFFDREENSTGALTSFLSTETKNLSGVSGVTLGTIIMTSTTLGAAMI 917
Query: 1302 TASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVR 1123
A WK+ L + P Q A+E S A EA +RTV
Sbjct: 918 IALAIGWKLALVCISVVPILLACGFLRFYMLAQFQQRSKSAYEGSASYACEATSAIRTVA 977
Query: 1122 ALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKE 943
+L E + + + LQK + + S + F ++ F +G L E
Sbjct: 978 SLTREQDVWGVYHDQLQKQGRKSLISVLRSSLLYASSQALVFFCVALGFWYGGTLLGHHE 1037
Query: 942 VAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKK- 766
+ ++ + A AG+ ++ PD KA +AA LF T+ S +G+K
Sbjct: 1038 YSIFRFFVCFSEILFGAQSAGTVFSFAPDMGKAKNAAAQFKKLFDSKPTIDIWSDEGEKL 1097
Query: 765 NIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYH 586
+GEI +V F Y RP++ +L G+NL V PG+ +ALVGPSGCGKST I+LLERFY
Sbjct: 1098 ESMEGEIEFRDVHFRYPTRPEQPVLRGLNLSVKPGQYIALVGPSGCGKSTTIALLERFYD 1157
Query: 585 AVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTR-SVPQLELEKA 409
A+ G V +D +++ +N+N RS L+LVSQEPTL+ +I+EN+L G+ + V + L K
Sbjct: 1158 ALAGGVFVDGKDITKLNVNSYRSFLSLVSQEPTLYQGTIKENILLGVDKDDVSEETLIKV 1217
Query: 408 LQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDS 229
+ AN ++FV P+G DT+VG +G LSGGQKQR+AIARA+LR+PKVLLLDEATSALDS
Sbjct: 1218 CKDANIYDFVMSLPEGFDTVVGSKGGMLSGGQKQRVAIARALLRDPKVLLLDEATSALDS 1277
Query: 228 DSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYW 49
+SEKVVQ ALD A+ +T+ VAHRLST+ NAD I V GK+ E GTH EL+R + Y+
Sbjct: 1278 ESEKVVQAALDAAARGRTTIAVAHRLSTIQNADIIYVFDQGKIVESGTHHELIRNKGRYY 1337
Query: 48 RLVQKQGI 25
LV Q +
Sbjct: 1338 ELVNLQSL 1345
Score = 296 bits (759), Expect = 2e-78
Identities = 197/629 (31%), Positives = 311/629 (49%), Gaps = 24/629 (3%)
Frame = -1
Query: 1818 VHDDDMERILDELSKEGAKKSNLREIVK---------QCRPDYCFLFIAVFGSAIQGVSY 1666
++DD + L E KE K+ VK R D + ++ + G +
Sbjct: 66 LNDDSLFAHLQEHEKEVLKRQLDAPSVKVSFFTLYRYASRKDILIILVSAICAIAAGAAL 125
Query: 1665 PILAQLIVRTYEGFAMIGEDMLYYSHLW------ALSFMFLAVFRPLTLYCQYYYFGKVS 1504
P+ L F I + Y + L F++L + +T+Y F
Sbjct: 126 PLFTILFGSLASAFQGISLGTMPYHEFYHKLTKNVLYFVYLGIAEFVTVYVSTVGFIYTG 185
Query: 1503 EQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVV 1324
E L+ ++R +L A++D A ++ R+ D++ ++ A+ +++G +
Sbjct: 186 EHLTQKIRENYLEAILRQNMAYFD--KLGAGEVTTRITADTNLIQDAISEKVGLTLTAFA 243
Query: 1323 AISIAITTASLYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEAL 1144
A A + WK+ L ++ ++ A E +
Sbjct: 244 TFVTAFIVAYVKYWKLALICTSTIVALVMVMGGGSRFIVKYSKKSIESYGAGGTVAEEVI 303
Query: 1143 ENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGT 964
++R A +DK+ HL + K K+ +I G G Y + F G+
Sbjct: 304 SSIRNATAFGTQDKLAKQYETHLAEAEKWGVKQQVILGMMIGGMFGIMFSNYGLGFWMGS 363
Query: 963 YLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFS 784
+ KEV VLM++ + + G+ A + V AA I+ + +
Sbjct: 364 RFVVGKEVNVGQVLTVLMSILIGSFSLGNVAPNGQAFTNGVAAAAKIYSTIDRRSPLDPY 423
Query: 783 SSDGKK-NIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIIS 607
S +GK + +G I NV+ Y RP+ ++ V+L + GKT ALVGPSG GKST++
Sbjct: 424 SDEGKVLDHFEGNIEFRNVKHIYPSRPEVTVMEDVSLSMPAGKTTALVGPSGSGKSTVVG 483
Query: 606 LLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQ 427
L+ERFY V G+V +D +++ +NL LR ++LVSQEP LF+ +I N+ +GL + +
Sbjct: 484 LVERFYLPVGGQVLLDGHDIQTLNLRWLRQQISLVSQEPVLFSTTIFRNIEHGLIGTKFE 543
Query: 426 LE--------LEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNP 271
E +E A + ANA +F+ P+G DT VG+RG LSGGQKQRIAIARAI+ +P
Sbjct: 544 HESKDKIRELVENAARMANAHDFIMALPEGYDTNVGQRGFLLSGGQKQRIAIARAIVSDP 603
Query: 270 KVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQ 91
K+LLLDEATSALD+ SE VVQ ALD A+E +T+V+AHRLST+ A +I + GK+AEQ
Sbjct: 604 KILLLDEATSALDTKSEGVVQAALDKAAEGRTTIVIAHRLSTIKTAHNIVAMVGGKIAEQ 663
Query: 90 GTHEELLRKRSIYWRLVQKQGIQVETPSD 4
GTH+EL+ ++ Y++LV+ Q I E ++
Sbjct: 664 GTHDELVDRKGTYYKLVEAQRINEEKEAE 692
>gi|18033873|gb|AAL57243.1| ATP-binding cassette transporter ABC4
[Venturia inaequalis]
Length = 1353
Score = 637 bits (1642), Expect = 0.0
Identities = 415/1266 (32%), Positives = 657/1266 (51%), Gaps = 77/1266 (6%)
Frame = -1
Query: 3588 VFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVT-ITNAINNKTIDPADLE 3412
+++ +S ++ + L V S+++G P M+ FG ++ + N I
Sbjct: 106 LYRYASRWDWAAWWLSVFCSIVSGAAMPLMTVVFGGLTGLFADYFKNVIT---------- 155
Query: 3411 KAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQ 3232
Y+++ ++ V +F F+ + YVG+ T ++R++Y+ +L+++
Sbjct: 156 --YKQFNSELSHFVLYFLYLAIGTFVTTYIMTVGFIYVGERCTGKIRERYLKAMLRQNIA 213
Query: 3231 YFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFF 3052
+FD + G ++T + + ++ +EK L + + F +AF W+L
Sbjct: 214 FFDKLGAGEVTTRITADTNLIQDGISEKFGLTLNALATFISAFVIAFIKYWKLTLILTST 273
Query: 3051 SLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEEL 2872
I + S+ V++ T + T YA G+IA + L + + + N Q + Y L
Sbjct: 274 VFAITLVMGVGSSFVVRWTVRSQTEYAKGGTIAEEVLSSVRNAIAFNTQDKLAKVYDSYL 333
Query: 2871 KAGEKYG--IRRALMYSISRGVTYFFCN-----------------SLNTVVLYVGATMIY 2749
E G ++ +L I+ +T + N +++ V+ + A MI
Sbjct: 334 VIAETNGRKLQMSLGAMIASMMTLIYLNYGLSFWQGSRFLVQGDMTVSQVLTVLFAVMIG 393
Query: 2748 SGTLE---------TAVVVRDDNV---------IEKDETDYDVEVEVNGNISFKNVKFSY 2623
+ +L T+ V + ++ D D V +++G I +NVK Y
Sbjct: 394 AFSLGNVAPNFKAFTSAVAAGQKIFAAIDRTSPMDPDSPDGKVLEKMSGPIELRNVKHIY 453
Query: 2622 PTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDM 2443
P+RP+ V+ G+ + G+ ALVGA GSGKS +V L+ +Y G +F+DG D+ ++
Sbjct: 454 PSRPEVVVMNGVDLIIPAGKQTALVGAFGSGKSPIVGLVERFYEPVGGEMFLDGHDIREI 513
Query: 2442 NIKRLRRVIGVVSQEPVLFNTTIEENIRFG---------NPNVSLPEIYGALRKANAYDF 2290
N+ LR+ I +V QEPVLF TTI ENIRFG +P I GA + ANA+DF
Sbjct: 514 NLHWLRQNISLVQQEPVLFATTIYENIRFGLLGTEFEKVDPERQRDLIEGAAKMANAHDF 573
Query: 2289 VCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKA 2110
+ +G +T VGERG LSGGQKQRIAIAR +V +PKILLLDEATSALD +SE VVQ A
Sbjct: 574 IMVLSEGYQTHVGERGFLLSGGQKQRIAIARAVVSDPKILLLDEATSALDTKSEGVVQAA 633
Query: 2109 LENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLE 1930
L+ A+QGRTTIV+AHRLSTI+NA I+VM +G IVE G H EL+ ++ Y +LV+AQ +
Sbjct: 634 LDKAAQGRTTIVIAHRLSTIKNADNIVVMSRGAIVEQGRHSELLERKSAYFNLVEAQRIA 693
Query: 1929 S---HDDHEELPPLAARQLSQELSPLHSYAIQRSTSNDAG--VHDDDMERI--------- 1792
+ +D+ EE+ + L + + R+ +N+ G + DD + +
Sbjct: 694 AEIKNDNPEEV---------EILQEVDGQKLHRAATNEKGEPIDPDDEDPVGRLKRMQSG 744
Query: 1791 ----LDELSKEGAKKSNLREIVKQC-------RPDYCFLFIAVFGSAIQGVSYPILAQLI 1645
EL K G +++ +++ + ++ + + S I G P+ A
Sbjct: 745 KSISSVELGKRGTEQTPEYSLLQLLGVVWSFNKTEWPIMLLGFICSVIAGGGNPVQAIFF 804
Query: 1644 VRTYEGFAMIG---EDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIK 1474
+ ++ ++ + W+L ++ LA + ++ + Q FG SE+L R R +
Sbjct: 805 AKAVSALSLPPAQYAELRSEINFWSLMYLMLAGTQLISNFGQATAFGYCSERLIHRARDQ 864
Query: 1473 SFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTAS 1294
+F HML F+D ++A L++ L+T S+ + LG ++ + +A+T +
Sbjct: 865 AFRHMLRQDIEFFDREENNAGSLTSFLSTSSTQLSGLSGSTLGTILQVSTTLVVAMTISL 924
Query: 1293 LYCWKMTLEVLMFFPXXXXXXXXXXXXXXXAIQEDTIAFENSNRTAIEALENVRTVRALN 1114
WK+ L + P A+ NS A EA +RTV +L
Sbjct: 925 AIGWKLALVCISAIPVLLACGFFRFWMLARFQARTKAAYVNSAGFACEATSAIRTVASLT 984
Query: 1113 LEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAP 934
E+ + L+ KS + A S S F ++ F +G L ++E +
Sbjct: 985 REEDVFEKYHAQLEAQAKSSLVSILKSSALYAASQSFIFFCIALGFWYGGTLIAKREYSQ 1044
Query: 933 MDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKK-NIE 757
++ M++ A AG+ ++ PD KA HAA + LF + S +G +
Sbjct: 1045 FQFFVCFMSIIFGAQSAGTIFSFAPDMGKAKHAAAELQTLFDRKPKIDCWSEEGDRLTSV 1104
Query: 756 KGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVD 577
+G + +V F Y RP++ +L G+NL + PG+ +ALVG SGCGKST I+LLERFY +
Sbjct: 1105 EGHVEFRDVHFRYPTRPEQPVLRGLNLSIKPGQYVALVGASGCGKSTTIALLERFYDPLS 1164
Query: 576 GEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTR-SVPQLELEKALQT 400
G V +D + V +N+N RS LALVSQEPTL+ +IREN+L G R VP+ E+ +A +
Sbjct: 1165 GGVYVDGQEVSKLNVNDYRSYLALVSQEPTLYQGTIRENVLLGADREGVPEDEIIRACKD 1224
Query: 399 ANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSE 220
AN ++F+ P G +T+ G++G LSGGQKQRIAIARA+LRNPK+LLLDEATSALDS+SE
Sbjct: 1225 ANIYDFIMSLPDGFNTVCGQKGGLLSGGQKQRIAIARALLRNPKILLLDEATSALDSESE 1284
Query: 219 KVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLV 40
++VQ ALD A++ +T+ VAHRLST+ AD I V+ G+V E+G+H LL K Y LV
Sbjct: 1285 QIVQLALDKAAKGRTTIAVAHRLSTIQKADVIYVIDGGRVVEEGSHNYLLSKNGRYAELV 1344
Query: 39 QKQGIQ 22
Q ++
Sbjct: 1345 MMQSLE 1350
Score = 301 bits (771), Expect = 8e-80
Identities = 222/712 (31%), Positives = 346/712 (48%), Gaps = 26/712 (3%)
Frame = -1
Query: 2061 LSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLESHDDHEELPPLAARQL 1882
L ++N S + V + + E I K + QA + D P +
Sbjct: 3 LGDVKNGSAVNVKDGSKTSRGSSETEEIEKDNARTQMGQAPVPGMDTD-----PSGGLKE 57
Query: 1881 SQELSPLHSYAIQRSTSNDAGVHDDDMERILDELSKEGAKKSNLREIVK---------QC 1729
+ + L S I+ ND D R L E +E ++ VK
Sbjct: 58 LKNMRKLDSNVIEVKDQND------DPFRHLPEHEQEILRRQTFIPDVKVGYFTLYRYAS 111
Query: 1728 RPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYYSHL------WALSFM 1567
R D+ +++VF S + G + P++ + FA ++++ Y + L F+
Sbjct: 112 RWDWAAWWLSVFCSIVSGAAMPLMTVVFGGLTGLFADYFKNVITYKQFNSELSHFVLYFL 171
Query: 1566 FLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNT 1387
+LA+ +T Y F V E+ + ++R + ML AF+D A ++ R+
Sbjct: 172 YLAIGTFVTTYIMTVGFIYVGERCTGKIRERYLKAMLRQNIAFFD--KLGAGEVTTRITA 229
Query: 1386 DSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLM-FFPXXXXXXXXXXXXX 1210
D++ ++ + ++ G + + A A + WK+TL + F
Sbjct: 230 DTNLIQDGISEKFGLTLNALATFISAFVIAFIKYWKLTLILTSTVFAITLVMGVGSSFVV 289
Query: 1209 XXAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQG 1030
++ T + A E L +VR A N +DK+ + +L + K + G
Sbjct: 290 RWTVRSQT-EYAKGGTIAEEVLSSVRNAIAFNTQDKLAKVYDSYLVIAETNGRKLQMSLG 348
Query: 1029 AANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYK 850
A ++ Y +SF G+ ++ ++ VL + + A G+ A +
Sbjct: 349 AMIASMMTLIYLNYGLSFWQGSRFLVQGDMTVSQVLTVLFAVMIGAFSLGNVAPNFKAFT 408
Query: 849 KAVHAAGLIFHLFTYPATMPFSSSDGKKNIEK--GEIIGENVQFHYDQRPDRMILNGVNL 676
AV A IF + M S DGK +EK G I NV+ Y RP+ +++NGV+L
Sbjct: 409 SAVAAGQKIFAAIDRTSPMDPDSPDGKV-LEKMSGPIELRNVKHIYPSRPEVVVMNGVDL 467
Query: 675 KVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQ 496
+ GK ALVG G GKS I+ L+ERFY V GE+ +D ++ +INL+ LR N++LV Q
Sbjct: 468 IIPAGKQTALVGAFGSGKSPIVGLVERFYEPVGGEMFLDGHDIREINLHWLRQNISLVQQ 527
Query: 495 EPTLFNCSIRENLLYGLTRSV-----PQLE---LEKALQTANAFNFVFQFPQGLDTLVGE 340
EP LF +I EN+ +GL + P+ + +E A + ANA +F+ +G T VGE
Sbjct: 528 EPVLFATTIYENIRFGLLGTEFEKVDPERQRDLIEGAAKMANAHDFIMVLSEGYQTHVGE 587
Query: 339 RGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVA 160
RG LSGGQKQRIAIARA++ +PK+LLLDEATSALD+ SE VVQ ALD A++ +T+V+A
Sbjct: 588 RGFLLSGGQKQRIAIARAVVSDPKILLLDEATSALDTKSEGVVQAALDKAAQGRTTIVIA 647
Query: 159 HRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQVETPSD 4
HRLST+ NAD+I V+ G + EQG H ELL ++S Y+ LV+ Q I E +D
Sbjct: 648 HRLSTIKNADNIVVMSRGAIVEQGRHSELLERKSAYFNLVEAQRIAAEIKND 699