Homology by BLASTX
BLASTX 2.2.4 [Aug-26-2002]
Query= Y75B8A_25
(6366 letters)
Database: /home/niguts/usr02/tshini/ykclst/db/nr.seq
1,967,186 sequences; 661,712,633 total letters
Score E
Sequences producing significant alignments: (bits) Value
gi|17556524|ref|NP_499596.1| type 3 phosphatidylinositol (3N342)... 3987 0.0
gi|39583262|emb|CAE60054.1| Hypothetical protein CBG03566 [Caeno... 3400 0.0
gi|50416360|gb|AAH77604.1| Unknown (protein for MGC:84514) [Xeno... 1277 0.0
gi|25742825|ref|NP_071637.1| phosphatidylinositol 4-kinase a [Ra... 1259 0.0
gi|17105400|ref|NP_477352.1| phosphatidylinositol 4-kinase, cata... 1255 0.0
gi|50233838|ref|NP_001001983.1| phosphatidylinositol 4-kinase, c... 1255 0.0
gi|27807043|ref|NP_777002.1| phosphatidylinositol 4-kinase, cata... 1244 0.0
gi|50756213|ref|XP_415062.1| PREDICTED: similar to phosphatidyli... 1232 0.0
gi|31231338|ref|XP_318507.1| ENSANGP00000021188 [Anopheles gambi... 1211 0.0
gi|47228503|emb|CAG05323.1| unnamed protein product [Tetraodon n... 1173 0.0
gi|23397467|ref|NP_570014.2| CG10260-PB [Drosophila melanogaster... 1147 0.0
gi|2136690|pir||S65741 1-phosphatidylinositol 4-kinase (EC 2.7.1... 1127 0.0
gi|7547268|gb|AAB36289.2| type 3 phosphatidylinositol 4-kinase [... 1126 0.0
gi|6691825|emb|CAB65858.1| EG:BACR7C10.2 [Drosophila melanogaster] 1088 0.0
gi|47226674|emb|CAG07833.1| unnamed protein product [Tetraodon n... 946 0.0
gi|21064847|gb|AAM29653.1| SD12145p [Drosophila melanogaster] 939 0.0
gi|32425423|gb|AAH18120.2| PIK4CA protein [Homo sapiens] 786 0.0
gi|32197216|gb|AAH53654.1| PIK4CA protein [Homo sapiens] 781 0.0
gi|4505807|ref|NP_002641.1| phosphatidylinositol 4-kinase, catal... 766 0.0
gi|30584637|gb|AAP36571.1| Homo sapiens phosphatidylinositol 4-k... 766 0.0
gi|29351621|gb|AAH49252.1| Pik4ca protein [Mus musculus] 631 e-179
gi|49093908|ref|XP_408415.1| hypothetical protein AN4278.2 [Aspe... 466 e-129
gi|48374081|ref|NP_955377.2| similar to phosphatidylinositol 4-k... 460 e-127
gi|19112096|ref|NP_595304.1| putative phosphatidylinositol 4-kin... 460 e-127
gi|46108558|ref|XP_381337.1| hypothetical protein FG01161.1 [Gib... 459 e-127
gi|32423243|ref|XP_332059.1| hypothetical protein [Neurospora cr... 457 e-126
gi|50256377|gb|EAL19102.1| hypothetical protein CNBH2020 [Crypto... 454 e-125
gi|18044951|gb|AAH20225.1| LOC220686 protein [Homo sapiens] 439 e-121
gi|49080384|ref|XP_403718.1| hypothetical protein UM06103.1 [Ust... 435 e-120
gi|50554169|ref|XP_504493.1| hypothetical protein [Yarrowia lipo... 430 e-118
gi|45187841|ref|NP_984064.1| ADL033Wp [Eremothecium gossypii] >g... 429 e-118
gi|50286513|ref|XP_445685.1| unnamed protein product [Candida gl... 427 e-117
gi|46431626|gb|EAK91167.1| hypothetical protein CaO19.9377 [Cand... 424 e-116
gi|46431631|gb|EAK91171.1| hypothetical protein CaO19.1814 [Cand... 424 e-116
gi|6323336|ref|NP_013408.1| functions in the PKC1 protein kinase... 417 e-114
gi|2340969|gb|AAB67354.1| Stt4p: phosphatidylinositol-4-kinase [... 417 e-114
gi|50306023|ref|XP_452973.1| unnamed protein product [Kluyveromy... 412 e-113
gi|33585469|gb|AAH55479.1| Pik4ca protein [Mus musculus] 409 e-112
gi|13702810|gb|AAK38486.1| putative phosphatidylinositol kinase ... 353 3e-95
gi|25453506|pir||T52022 1-phosphatidylinositol 4-kinase (EC 2.7.... 353 4e-95
gi|22330126|ref|NP_175359.2| phosphatidylinositol 3- and 4-kinas... 353 4e-95
gi|25405292|pir||F96529 probable Phosphatidylinositol 4-kinase P... 353 4e-95
gi|22797099|emb|CAD22138.1| phosphatidylinositol 4-kinase [Oryza... 352 9e-95
gi|15223705|ref|NP_175516.1| phosphatidylinositol 4-kinase, puta... 266 6e-69
gi|42733896|gb|AAS38812.1| similar to Homo sapiens (Human). Phos... 259 8e-67
gi|34533518|dbj|BAC86726.1| unnamed protein product [Homo sapiens] 254 2e-65
gi|19074845|ref|NP_586351.1| PHOSPHATIDYLINOSITOL 4-KINASE (C-te... 254 2e-65
gi|4096762|gb|AAD10400.1| phosphatidylinositol 4-kinase [Rattus ... 201 2e-49
gi|1730568|sp|P54677|PI4K_DICDI Phosphatidylinositol 4-kinase (P... 187 3e-45
gi|48097614|ref|XP_391922.1| similar to ENSANGP00000009420 [Apis... 182 9e-44
gi|24654710|ref|NP_728519.1| CG7004-PC [Drosophila melanogaster]... 178 2e-42
gi|50782499|ref|XP_423394.1| PREDICTED: similar to PIK4CB protei... 178 2e-42
gi|17933718|ref|NP_524822.1| CG7004-PA [Drosophila melanogaster]... 178 2e-42
gi|12652575|gb|AAH00029.1| PIK4CB protein [Homo sapiens] >gnl|BL... 177 3e-42
gi|1894947|gb|AAC51156.1| PtdIns 4-kinase [Homo sapiens] 177 3e-42
gi|4505809|ref|NP_002642.1| phosphatidylinositol 4-kinase, catal... 177 3e-42
gi|38372507|sp|Q9UBF8|P4KB_HUMAN Phosphatidylinositol 4-kinase b... 177 3e-42
gi|33303741|gb|AAQ02384.1| phosphatidylinositol 4-kinase, cataly... 177 3e-42
gi|14389295|ref|NP_112345.1| phosphatidylinositol 4-kinase b [Ra... 176 5e-42
gi|38372429|sp|O02810|P4KB_BOVIN Phosphatidylinositol 4-kinase b... 176 5e-42
gi|26324936|dbj|BAC26222.1| unnamed protein product [Mus musculus] 176 5e-42
gi|27807505|ref|NP_777208.1| phosphatidylinositol 4-kinase, cata... 176 5e-42
gi|29648332|ref|NP_780565.1| phosphatidylinositol 4-kinase, cata... 176 5e-42
gi|49119578|gb|AAH73706.1| Unknown (protein for MGC:83640) [Xeno... 176 7e-42
gi|6979325|gb|AAF34418.1| putative phosphatidylinositol 4-kinase... 173 6e-41
gi|20796713|emb|CAC81902.1| phophatdylinositol 4-kinase [Oryza s... 172 1e-40
gi|31198835|ref|XP_308365.1| ENSANGP00000009420 [Anopheles gambi... 169 6e-40
gi|7649667|emb|CAB88874.1| phosphatidylinositol 4-kinase [Solanu... 168 1e-39
gi|7489248|pir||T07007 probable 1-phosphatidylinositol 4-kinase ... 168 1e-39
gi|17567491|ref|NP_508177.1| phosphatidylinositol (XB538) [Caeno... 167 4e-39
gi|15237610|ref|NP_201212.1| phosphatidylinositol 4-kinase (PI4K... 165 1e-38
gi|25453507|pir||T52631 1-phosphatidylinositol 4-kinase (EC 2.7.... 165 1e-38
gi|15242394|ref|NP_196497.1| phosphatidylinositol 4-kinase, puta... 164 2e-38
gi|39592522|emb|CAE63599.1| Hypothetical protein CBG08090 [Caeno... 162 1e-37
gi|50545769|ref|XP_500423.1| hypothetical protein [Yarrowia lipo... 156 7e-36
gi|50304695|ref|XP_452303.1| unnamed protein product [Kluyveromy... 155 9e-36
gi|46229113|gb|EAK89962.1| membrane associated protein with 2 tr... 155 2e-35
gi|9955522|emb|CAC05461.1| putative protein [Arabidopsis thaliana] 155 2e-35
gi|32398915|emb|CAD98380.1| PI3_PI4_kinase, possible [Cryptospor... 155 2e-35
gi|3688225|emb|CAA09718.1| phosphatidylinositol 4-kinase [Candid... 154 4e-35
gi|5771512|gb|AAD51410.1| unknown [Candida albicans] >gnl|BL_ORD... 154 4e-35
gi|45199185|ref|NP_986214.1| AFR666Cp [Eremothecium gossypii] >g... 152 8e-35
gi|19115611|ref|NP_594699.1| phosphatidylinositol 3-kinase vps34... 152 1e-34
gi|25751343|pir||T52538 1-phosphatidylinositol 3-kinase (EC 2.7.... 152 1e-34
gi|50422459|ref|XP_459796.1| DhPIK1 [Debaryomyces hansenii] >gnl... 152 1e-34
gi|1076903|pir||PC4002 phosphatidylinositol-3 kinase (EC 3.1.3.-... 151 2e-34
gi|23613121|ref|NP_703443.1| phosphatidylinositol 4-kinase, puta... 150 3e-34
gi|47226677|emb|CAG07836.1| unnamed protein product [Tetraodon n... 149 1e-33
gi|50291259|ref|XP_448062.1| unnamed protein product [Candida gl... 149 1e-33
gi|49077354|ref|XP_402546.1| hypothetical protein UM04931.1 [Ust... 147 3e-33
gi|46122243|ref|XP_385675.1| hypothetical protein FG05499.1 [Gib... 147 3e-33
gi|6324062|ref|NP_014132.1| catalyzes first step in the biosynth... 147 4e-33
gi|7488909|pir||T14293 1-phosphatidylinositol 4-kinase homolog -... 144 2e-32
gi|23478881|gb|EAA15852.1| phosphatidylinositol 4-kinase-related... 142 1e-31
gi|19115754|ref|NP_594842.1| putative phosphatidylinositol 4-kin... 139 1e-30
gi|38110640|gb|EAA56328.1| hypothetical protein MG06299.4 [Magna... 138 2e-30
gi|50256750|gb|EAL19470.1| hypothetical protein CNBG4170 [Crypto... 138 2e-30
gi|5771504|gb|AAD51405.1| PIKa [Candida albicans] >gnl|BL_ORD_ID... 135 1e-29
gi|50729062|ref|XP_416412.1| PREDICTED: similar to Phosphatidyli... 134 2e-29
gi|1709527|sp|P54675|P3K3_DICDI Phosphatidylinositol 3-kinase 3 ... 133 5e-29
gi|50404944|ref|YP_054036.1| Phosphatidylinositol 4-kinase, puta... 133 5e-29
gi|28829799|gb|AAO52301.1| similar to Dictyostelium discoideum (... 132 1e-28
gi|31198303|ref|XP_308099.1| ENSANGP00000019761 [Anopheles gambi... 130 3e-28
gi|46128289|ref|XP_388698.1| hypothetical protein FG08522.1 [Gib... 130 3e-28
gi|50555610|ref|XP_505213.1| hypothetical protein [Yarrowia lipo... 130 4e-28
gi|47213156|emb|CAF93846.1| unnamed protein product [Tetraodon n... 129 1e-27
gi|1709526|sp|P54674|P3K2_DICDI Phosphatidylinositol 3-kinase 2 ... 129 1e-27
gi|16758806|ref|NP_446375.1| phosphatidylinositol 3-kinase, C2 d... 127 4e-27
gi|46228715|gb|EAK89585.1| phosphatidylinositol 4-kinase [Crypto... 126 6e-27
gi|1709525|sp|P54673|P3K1_DICDI Phosphatidylinositol 3-kinase 1 ... 125 1e-26
gi|19173068|ref|NP_597619.1| PHOSPHATIDYLINOSITOL-4-KINASE CATAL... 124 3e-26
gi|32408711|ref|XP_324836.1| hypothetical protein [Neurospora cr... 124 4e-26
gi|14245711|dbj|BAB56149.1| phosphatidylinositol 4-kinase like p... 123 5e-26
gi|29246528|gb|EAA38121.1| GLP_44_18876_25655 [Giardia lamblia A... 123 5e-26
gi|11513658|pdb|1E8Y|A Chain A, Structure Determinants Of Phosph... 123 5e-26
gi|21237725|ref|NP_002640.2| phosphoinositide-3-kinase, catalyti... 123 5e-26
gi|12620871|gb|AAG61115.1| phosphoinositide-3-kinase gamma catal... 123 5e-26
gi|1709513|sp|P48736|P11G_HUMAN Phosphatidylinositol-4,5-bisphos... 123 5e-26
gi|13096755|pdb|1HE8|A Chain A, Ras G12v - Pi 3-Kinase Gamma Com... 123 5e-26
gi|48138217|ref|XP_396869.1| similar to ENSANGP00000019761 [Apis... 123 7e-26
gi|33358197|pdb|1E7V|A Chain A, Structure Determinants Of Phosph... 121 2e-25
gi|2135918|pir||A57134 1-phosphatidylinositol 3-kinase (EC 2.7.1... 121 2e-25
gi|11513657|pdb|1E8X|A Chain A, Structural Insights Into Phoshoi... 121 2e-25
gi|12084791|pdb|1E7U|A Chain A, Structure Determinants Of Phosph... 121 2e-25
gi|47522612|ref|NP_999104.1| catalytic subunit of G-beta-gamma-a... 121 2e-25
gi|5453892|ref|NP_006209.1| phosphoinositide-3-kinase, catalytic... 121 3e-25
gi|50747824|ref|XP_421003.1| PREDICTED: similar to phosphoinosit... 121 3e-25
gi|6679317|ref|NP_032865.1| phosphatidylinositol 3-kinase, catal... 120 4e-25
gi|49094770|ref|XP_408846.1| hypothetical protein AN4709.2 [Aspe... 120 4e-25
gi|33304049|gb|AAQ02532.1| phosphoinositide-3-kinase, catalytic,... 120 6e-25
gi|1763626|gb|AAB39753.1| phosphoinositide 3'-hydroxykinase p110... 120 6e-25
gi|27807037|ref|NP_776999.1| phosphoinositide-3-kinase, catalyti... 120 6e-25
gi|47227919|emb|CAF97548.1| unnamed protein product [Tetraodon n... 119 7e-25
gi|30048086|gb|AAH51246.1| Pik3cg protein [Mus musculus] 119 7e-25
gi|9937984|ref|NP_064668.1| phosphoinositide-3-kinase, catalytic... 119 7e-25
gi|1709528|sp|P54676|P3K4_DICDI Phosphatidylinositol 3-kinase VP... 118 2e-24
gi|7511986|pir||T13801 phosphoinositide 3-kinase (EC 2.7.-.-) - ... 117 4e-24
gi|1272420|gb|AAC47117.1| phosphoinositide 3-kinase [Drosophila ... 117 4e-24
gi|24662891|ref|NP_524028.2| CG11621-PA [Drosophila melanogaster... 117 4e-24
gi|50752436|ref|XP_422779.1| PREDICTED: similar to phosphoinosit... 117 5e-24
gi|2245503|gb|AAB62532.1| gag-v-phosphoinositide 3-kinase cataly... 116 8e-24
gi|4758924|ref|NP_004561.1| phosphoinositide-3-kinase, class 2, ... 115 1e-23
gi|50259960|gb|EAL22626.1| hypothetical protein CNBB2580 [Crypto... 115 2e-23
gi|11259849|pir||T42642 phosphoinositide 3-kinase (EC 2.7.1.-) -... 115 2e-23
gi|37589499|gb|AAH59895.1| Unknown (protein for MGC:69841) [Mus ... 115 2e-23
gi|34859032|ref|XP_341912.1| similar to phosphoinositide 3-kinas... 115 2e-23
gi|4505799|ref|NP_002636.1| phosphoinositide-3-kinase, class 2, ... 114 2e-23
gi|13812241|ref|NP_113372.1| phosphatidylinositol 4-kinase [Guil... 114 2e-23
gi|6323269|ref|NP_013341.1| phosphatidylinositol 3-kinase; Vps34... 114 3e-23
gi|23613175|ref|NP_703497.1| phosphatidylinositol 3-kinase, puta... 114 3e-23
gi|46810282|ref|NP_997566.1| phosphatidylinositol 3-kinase, C2 d... 113 5e-23
gi|1171966|sp|P42348|P3K2_SOYBN Phosphatidylinositol 3-kinase, n... 112 1e-22
gi|7434349|pir||JC5985 phosphoinositide 3-kinase C2gamma - mouse 112 1e-22
gi|11890408|gb|AAG41122.1| phosphatidylinositol 3-kinase gamma i... 112 2e-22
gi|50760287|ref|XP_417956.1| PREDICTED: similar to phosphoinosit... 111 2e-22
gi|1171965|sp|P42347|P3K1_SOYBN Phosphatidylinositol 3-kinase, r... 111 3e-22
gi|34783827|gb|AAH57425.1| LOC407647 protein [Danio rerio] 110 3e-22
gi|50288595|ref|XP_446727.1| unnamed protein product [Candida gl... 110 3e-22
gi|46362436|gb|AAH68983.1| Zgc:77033 protein [Danio rerio] 110 3e-22
gi|39589346|emb|CAE74375.1| Hypothetical protein CBG22101 [Caeno... 110 3e-22
gi|6671486|gb|AAF23185.1| Related to yeast vacuolar protein sort... 110 6e-22
gi|17509429|ref|NP_491741.1| related to yeast Vacuolar Protein S... 110 6e-22
gi|7494717|pir||T25442 hypothetical protein B0025.1 - Caenorhabd... 110 6e-22
gi|6755058|ref|NP_035213.1| phosphatidylinositol 3-kinase, C2 do... 109 8e-22
gi|34880210|ref|XP_213879.2| similar to phosphoinositide-3-kinas... 109 1e-21
gi|38073314|ref|XP_283638.2| similar to Phosphatidylinositol-4-p... 109 1e-21
gi|23491282|gb|EAA22859.1| phosphatidylinositol 3-kinase vps34-l... 108 1e-21
gi|27552468|emb|CAD56881.1| phosphatidylinositol 3-kinase [Medic... 108 1e-21
gi|3954946|emb|CAA74194.1| PI-3 kinase [Homo sapiens] 108 1e-21
gi|13632400|sp|O00750|PK3B_HUMAN Phosphatidylinositol-4-phosphat... 108 1e-21
gi|15451926|ref|NP_002637.2| phosphoinositide-3-kinase, class 2,... 108 1e-21
gi|38100735|gb|EAA47826.1| hypothetical protein MG03069.4 [Magna... 107 3e-21
gi|29789235|ref|NP_083370.1| phosphatidylinositol 3-kinase, cata... 107 4e-21
gi|49067556|ref|XP_398068.1| hypothetical protein UM00453.1 [Ust... 107 4e-21
gi|12621140|ref|NP_075247.1| phosphatidylinositol 3-kinase; PI-3... 106 8e-21
gi|34761064|ref|NP_002638.2| phosphoinositide-3-kinase, class 3;... 106 8e-21
gi|26334015|dbj|BAC30725.1| unnamed protein product [Mus musculus] 105 1e-20
gi|19923289|ref|NP_005017.2| phosphoinositide-3-kinase, catalyti... 105 1e-20
gi|37496959|emb|CAA71149.2| phosphoinositide 3-kinase [Homo sapi... 105 1e-20
gi|3024334|sp|O00329|P11D_HUMAN Phosphatidylinositol-4,5-bisphos... 105 1e-20
gi|42475974|ref|NP_852079.2| phosphoinositide-3-kinase, class 3 ... 105 1e-20
gi|1362886|pir||S57219 1-phosphatidylinositol 3-kinase (EC 2.7.1... 105 1e-20
gi|987948|emb|CAA87094.1| phosphatidylinositol 3-kinase [Homo sa... 105 1e-20
gi|50752070|ref|XP_422639.1| PREDICTED: similar to Phosphatidyli... 105 1e-20
gi|6679319|ref|NP_032866.1| phosphatidylinositol 3-kinase cataly... 104 2e-20
gi|2076751|gb|AAB53966.1| phosphatidylinositol 3-kinase delta ca... 104 2e-20
gi|16758236|ref|NP_445933.1| phosphatidylinositol 3-kinase, cata... 104 2e-20
gi|47224849|emb|CAG06419.1| unnamed protein product [Tetraodon n... 104 3e-20
gi|22758919|gb|AAN05615.1| phosphoinositide 3 kinase P110delta [... 103 4e-20
gi|33304015|gb|AAQ02515.1| phosphoinositide-3-kinase, catalytic,... 103 4e-20
gi|5453894|ref|NP_006210.1| phosphoinositide-3-kinase, catalytic... 103 4e-20
gi|50603967|gb|AAH77528.1| Unknown (protein for MGC:83282) [Xeno... 103 7e-20
gi|47206366|emb|CAF94954.1| unnamed protein product [Tetraodon n... 103 7e-20
gi|24711346|gb|AAN62481.1| phosphatidylinositol 3-kinase [Brassi... 102 1e-19
gi|11259838|pir||T43628 phosphatidylinositol 3-kinase homolog - ... 102 2e-19
gi|31204385|ref|XP_311141.1| ENSANGP00000020426 [Anopheles gambi... 101 3e-19
gi|17137150|ref|NP_477133.1| CG5373-PA [Drosophila melanogaster]... 101 3e-19
gi|1854505|emb|CAA68185.1| 1-phosphatidylinositol 3-kinase [Dros... 101 3e-19
gi|37515284|gb|AAH35203.2| Phosphatidylinositol 3-kinase catalyt... 100 4e-19
gi|47211953|emb|CAF90089.1| unnamed protein product [Tetraodon n... 100 5e-19
gi|17567531|ref|NP_510529.1| 2 polypeptide (XP854) [Caenorhabdit... 100 6e-19
gi|6755060|ref|NP_035214.1| phosphatidylinositol 3-kinase, C2 do... 99 1e-18
gi|26346703|dbj|BAC37000.1| unnamed protein product [Mus musculus] 99 1e-18
gi|5453189|gb|AAD43472.1| phosphatidylinositol 3-kinase Pdd1p [P... 99 2e-18
gi|47206233|emb|CAF91363.1| unnamed protein product [Tetraodon n... 99 2e-18
gi|31236716|ref|XP_319464.1| ENSANGP00000002906 [Anopheles gambi... 98 3e-18
gi|34015227|gb|AAQ56420.1| putative kinase [Oryza sativa (japoni... 98 3e-18
gi|47207889|emb|CAF89996.1| unnamed protein product [Tetraodon n... 97 4e-18
gi|47226675|emb|CAG07834.1| unnamed protein product [Tetraodon n... 97 5e-18
gi|15219743|ref|NP_176251.1| phosphatidylinositol 3-kinase (PI3K... 97 7e-18
gi|45200984|ref|NP_986554.1| AGL113Cp [Eremothecium gossypii] >g... 97 7e-18
gi|19347828|gb|AAL86326.1| putative phosphatidylinositol 3-kinas... 96 1e-17
gi|50759285|ref|XP_417602.1| PREDICTED: similar to phosphoinosit... 96 1e-17
gi|21756282|dbj|BAC04851.1| unnamed protein product [Homo sapien... 96 1e-17
gi|47213737|emb|CAF96098.1| unnamed protein product [Tetraodon n... 95 3e-17
gi|555700|gb|AAA83427.1| phosphatidylinositol 3-kinase 94 4e-17
gi|50307787|ref|XP_453887.1| unnamed protein product [Kluyveromy... 94 4e-17
gi|2499560|sp|Q92213|VP34_CANAL Phosphatidylinositol 3-kinase VP... 94 4e-17
gi|46440622|gb|EAK99926.1| hypothetical protein CaO19.6243 [Cand... 94 4e-17
gi|46440531|gb|EAK99836.1| hypothetical protein CaO19.13621 [Can... 94 4e-17
gi|1850329|gb|AAC47459.1| AGE-1 [Caenorhabditis elegans] 92 1e-16
gi|7484352|pir||T08420 1-phosphatidylinositol 3-kinase (EC 2.7.1... 92 2e-16
gi|32398759|emb|CAD98719.1| phosphatidylinositol 3-kinase, root ... 92 2e-16
gi|19353278|gb|AAH24675.1| Pik3c3 protein [Mus musculus] 92 2e-16
gi|17531311|ref|NP_496462.1| AGEing alteration AGE-1, abnormal D... 91 3e-16
gi|47224471|emb|CAG08721.1| unnamed protein product [Tetraodon n... 91 3e-16
gi|7511517|pir||S71792 phosphatidylinositol-3-OH kinase AGE-1 - ... 91 3e-16
gi|15077853|gb|AAK83379.1| phosphatidylinositol 3-kinase alpha c... 91 5e-16
gi|41055186|ref|NP_957493.1| similar to phosphoinositide-3-kinas... 90 8e-16
gi|12833769|dbj|BAB22657.1| unnamed protein product [Mus musculus] 87 4e-15
gi|13097276|gb|AAH03393.1| Unknown (protein for IMAGE:3447173) [... 87 5e-15
gi|34872607|ref|XP_345607.1| similar to Phosphatidylinositol-4,5... 87 7e-15
gi|47228805|emb|CAG07537.1| unnamed protein product [Tetraodon n... 85 2e-14
gi|50427021|ref|XP_462115.1| unnamed protein product [Debaryomyc... 85 2e-14
gi|47211517|emb|CAF90313.1| unnamed protein product [Tetraodon n... 85 2e-14
gi|4096760|gb|AAD10399.1| phosphatidylinositol 4-kinase [Rattus ... 84 6e-14
gi|50806186|ref|XP_428802.1| PREDICTED: similar to phosphoinosit... 83 8e-14
gi|21356197|ref|NP_650902.1| CG4141-PA [Drosophila melanogaster]... 82 2e-13
gi|12329946|emb|CAC24651.1| probable phosphatidylinositol 3-kina... 80 6e-13
gi|39597255|emb|CAE59483.1| Hypothetical protein CBG02868 [Caeno... 80 6e-13
gi|6525041|gb|AAF15300.1| phosphoinositide 3 kinase catalytic su... 80 8e-13
gi|47212588|emb|CAG12813.1| unnamed protein product [Tetraodon n... 79 2e-12
gi|39596671|emb|CAE63290.1| Hypothetical protein CBG07670 [Caeno... 78 3e-12
gi|34864270|ref|XP_234053.2| similar to phosphatidylinositol 3-k... 77 4e-12
gi|7434346|pir||PC4346 phosphoinositide 3-kinase (EC 2.7.-.-) T1... 76 9e-12
gi|47213438|emb|CAF89545.1| unnamed protein product [Tetraodon n... 75 2e-11
gi|7434348|pir||PC4345 phosphoinositide 3-kinase (EC 2.7.-.-) T9... 72 2e-10
gi|7434347|pir||PC4347 phosphoinositide 3-kinase (EC 2.7.-.-) T1... 70 5e-10
gi|29249411|gb|EAA40923.1| GLP_186_22597_27513 [Giardia lamblia ... 66 1e-08
gi|50549817|ref|XP_502380.1| hypothetical protein [Yarrowia lipo... 65 2e-08
gi|7434342|pir||PC4348 phosphoinositide 3-kinase (EC 2.7.-.-) T1... 58 3e-06
gi|2109287|gb|AAC50016.1| phosphatidylinositol 3-kinase [Chlamyd... 57 8e-06
gi|29249882|gb|EAA41385.1| GLP_630_45311_38844 [Giardia lamblia ... 56 1e-05
gi|549092|sp|P32600|TOR2_YEAST Phosphatidylinositol 3-kinase TOR... 55 3e-05
gi|31225818|ref|XP_317619.1| ENSANGP00000007283 [Anopheles gambi... 55 3e-05
gi|468739|emb|CAA52849.1| TOR1 [Saccharomyces cerevisiae] 55 3e-05
gi|6322526|ref|NP_012600.1| Involved in cell cycle signaling and... 55 3e-05
gi|408956|gb|AAB66881.1| mutant drr1-1 protein [Saccharomyces ce... 55 3e-05
gi|742559|prf||2010264B TOR2(DRR2) gene 55 3e-05
gi|42759860|ref|NP_012719.2| putative protein/phosphatidylinosit... 55 3e-05
gi|39594638|emb|CAE72216.1| Hypothetical protein CBG19327 [Caeno... 54 4e-05
gi|17864562|ref|NP_524891.1| CG5092-PA [Drosophila melanogaster]... 54 4e-05
gi|15292447|gb|AAK93492.1| SD02269p [Drosophila melanogaster] 54 4e-05
gi|17861886|gb|AAL39420.1| GM10438p [Drosophila melanogaster] 54 4e-05
gi|11136977|emb|CAC15570.1| rapamycin associated protein FRAP2 [... 54 5e-05
gi|50759309|ref|XP_417614.1| PREDICTED: similar to FKBP-rapamyci... 54 5e-05
gi|28569600|gb|AAO43977.1| Tor [Dictyostelium discoideum] 54 5e-05
gi|9910228|ref|NP_064393.1| FK506 binding protein 12-rapamycin a... 54 5e-05
gi|744518|prf||2014422A FKBP-rapamycin-associated protein 54 5e-05
gi|4826730|ref|NP_004949.1| FK506 binding protein 12-rapamycin a... 54 5e-05
gi|9845251|ref|NP_063971.1| rapamycin and FKBP12 target-1 protei... 54 5e-05
gi|3282239|gb|AAC39933.1| rapamycin associated protein FRAP2 [Ho... 54 5e-05
gi|806955|gb|AAB32956.1| RAPT1=putative novel phosphatidylinosit... 54 5e-05
gi|40888981|gb|AAR97336.1| target of rapamycin [Aedes aegypti] 54 5e-05
gi|46127511|ref|XP_388309.1| hypothetical protein FG08133.1 [Gib... 54 6e-05
gi|32408649|ref|XP_324805.1| hypothetical protein [Neurospora cr... 54 6e-05
gi|32563905|ref|NP_491549.2| lethal protein 363 family member, L... 53 8e-05
gi|41018240|sp|Q95Q95|TOR_CAEEL Target of rapamycin homolog (CeT... 53 8e-05
gi|7507297|pir||T24588 hypothetical protein T06E4.3 - Caenorhabd... 53 8e-05
gi|45198938|ref|NP_985967.1| AFR420Wp [Eremothecium gossypii] >g... 53 8e-05
gi|25151810|ref|NP_505487.2| ataxia Telangectasia mutated ATM-Li... 53 8e-05
gi|6434317|emb|CAA94790.2| Hypothetical protein T06E4.3a [Caenor... 53 8e-05
gi|32563909|ref|NP_491552.2| lethal protein 363, LEThal LET-363 ... 53 8e-05
gi|50304405|ref|XP_452152.1| unnamed protein product [Kluyveromy... 53 1e-04
gi|7497597|pir||T28923 hypothetical protein C48B6.6 - Caenorhabd... 53 1e-04
gi|32409965|ref|XP_325463.1| hypothetical protein [Neurospora cr... 53 1e-04
gi|25405349|pir||G96536 hypothetical protein F2J10.9 [imported] ... 53 1e-04
gi|20260640|gb|AAM13218.1| unknown protein [Arabidopsis thaliana... 53 1e-04
gi|22330143|ref|NP_175425.2| target of rapamycin protein (TOR) [... 53 1e-04
gi|25150275|ref|NP_491970.2| suppressor with Morphological effec... 53 1e-04
gi|24640238|ref|NP_727132.1| CG32743-PA [Drosophila melanogaster... 52 1e-04
gi|19112151|ref|NP_595359.1| putative phosphatidylinositol-kinas... 52 1e-04
gi|46434639|gb|EAK94043.1| hypothetical protein CaO19.1903 [Cand... 52 1e-04
gi|26400729|sp|Q9Y7K2|TOR2_SCHPO Phosphatidylinositol 3-kinase t... 52 1e-04
gi|40215825|gb|AAR82784.1| LD17186p [Drosophila melanogaster] 52 2e-04
gi|50291629|ref|XP_448247.1| unnamed protein product [Candida gl... 52 2e-04
gi|50555395|ref|XP_505106.1| hypothetical protein [Yarrowia lipo... 52 2e-04
gi|19074668|ref|NP_586174.1| PHOSPHATIDYL INOSITOL-3-KINASE (C-T... 52 2e-04
gi|47824786|emb|CAG30554.1| TorA protein [Emericella nidulans] 52 2e-04
gi|39595784|emb|CAE67287.1| Hypothetical protein CBG12735 [Caeno... 52 2e-04
gi|49073198|ref|XP_400831.1| hypothetical protein UM03216.1 [Ust... 52 2e-04
gi|49097318|ref|XP_410119.1| hypothetical protein AN5982.2 [Aspe... 52 2e-04
gi|1654096|emb|CAA70297.1| RAD3 [Schizosaccharomyces pombe] >gnl... 51 3e-04
gi|19112149|ref|NP_595357.1| rad3 checkpoint protein [Schizosacc... 51 3e-04
gi|50425533|ref|XP_461362.1| unnamed protein product [Debaryomyc... 51 4e-04
gi|50287131|ref|XP_445995.1| unnamed protein product [Candida gl... 51 4e-04
gi|46226870|gb|EAK87836.1| FRP1 like protein involved in DNA rep... 50 5e-04
gi|24647031|ref|NP_650435.1| CG6535-PA [Drosophila melanogaster]... 50 5e-04
gi|40743853|gb|AAR89513.1| ATM protein [Drosophila melanogaster] 50 5e-04
gi|21063935|gb|AAM29197.1| AT01448p [Drosophila melanogaster] 50 5e-04
gi|50556528|ref|XP_505672.1| hypothetical protein [Yarrowia lipo... 50 5e-04
gi|45125076|emb|CAD89223.1| SMG1 protein [Drosophila melanogaster] 50 7e-04
gi|47211480|emb|CAG13362.1| unnamed protein product [Tetraodon n... 50 7e-04
gi|19113067|ref|NP_596275.1| putative phosphatidylinositol 3-kin... 50 0.001
gi|50257481|gb|EAL20188.1| hypothetical protein CNBF2640 [Crypto... 49 0.001
gi|38198590|emb|CAE53956.1| ataxia telangiectasia mutated [Danio... 49 0.001
gi|50423399|ref|XP_460282.1| unnamed protein product [Debaryomyc... 49 0.002
gi|47212122|emb|CAG06224.1| unnamed protein product [Tetraodon n... 49 0.002
gi|49068872|ref|XP_398725.1| hypothetical protein UM01110.1 [Ust... 49 0.002
gi|50305889|ref|XP_452905.1| unnamed protein product [Kluyveromy... 49 0.002
gi|7494076|pir||T14176 probable phosphatidylinositol 3 kinase - ... 49 0.002
gi|46431886|gb|EAK91407.1| hypothetical protein CaO19.8870 [Cand... 49 0.002
gi|46431896|gb|EAK91416.1| hypothetical protein CaO19.1283 [Cand... 49 0.002
gi|11692798|gb|AAG40002.1| ataxia telangiectasia and Rad3-relate... 48 0.004
gi|11385422|gb|AAG34794.1| Atr protein [Xenopus laevis] 48 0.004
gi|50731089|ref|XP_417160.1| PREDICTED: similar to ATM [Gallus g... 48 0.004
gi|48098271|ref|XP_392036.1| similar to PI-3-kinase ATX [Apis me... 48 0.004
gi|4502325|ref|NP_001175.1| ataxia telangiectasia and Rad3 relat... 47 0.005
gi|1235902|gb|AAC50405.1| FRAP-related protein >gnl|BL_ORD_ID|30... 47 0.005
gi|33944353|ref|XP_340324.1| phosphatidylinositol 3-kinase, puta... 47 0.005
gi|6680740|ref|NP_031525.1| ataxia telangiectasia mutated homolo... 47 0.006
gi|45595560|gb|AAH67212.1| Atm protein [Mus musculus] 47 0.006
gi|38100260|gb|EAA47413.1| hypothetical protein MG02656.4 [Magna... 47 0.006
gi|47208584|emb|CAF90921.1| unnamed protein product [Tetraodon n... 47 0.006
gi|47218239|emb|CAF96276.1| unnamed protein product [Tetraodon n... 47 0.006
gi|9366704|emb|CAB95466.1| phosphatidylinositol 3-kinase, probab... 47 0.008
gi|7385181|gb|AAF61728.1| protein kinase ATR [Mus musculus] 46 0.010
gi|49103003|ref|XP_411112.1| hypothetical protein AN6975.2 [Aspe... 46 0.010
gi|49083858|ref|XP_404175.1| hypothetical protein AN0038.2 [Aspe... 46 0.010
gi|5825606|gb|AAD53316.1| UVSB [Aspergillus nidulans] 46 0.010
gi|5853096|gb|AAD54313.1| UVSB PI-3 kinase [Emericella nidulans] 46 0.010
gi|28850398|gb|AAO53167.1| similar to Homo sapiens (Human). KIAA... 46 0.010
gi|24181422|gb|AAM33436.1| phosphatidylinositol kinase-related k... 46 0.013
gi|29246072|gb|EAA37683.1| GLP_171_17599_22176 [Giardia lamblia ... 46 0.013
gi|45185338|ref|NP_983055.1| ABR108Cp [Eremothecium gossypii] >g... 46 0.013
gi|6045181|dbj|BAA85312.1| ataxia telangiectasia mutated [Gallus... 46 0.013
gi|7511960|pir||T13288 mei-41 protein - fruit fly (Drosophila me... 46 0.013
gi|24642511|ref|NP_523369.2| CG4252-PA [Drosophila melanogaster]... 46 0.013
gi|19075626|ref|NP_588126.1| phosphotidylinositol kinase, tel1p;... 46 0.013
gi|6319612|ref|NP_009694.1| Central regulator of the Mec1p/Tel1p... 45 0.018
gi|950173|gb|AAA74482.1| Mec1p 45 0.018
gi|506876|dbj|BAA01860.1| Esr1 protein [Saccharomyces cerevisiae] 45 0.018
gi|4323240|gb|AAD16273.1| phosphatidylinositol 3-kinase TOR1 [Cr... 45 0.023
gi|50257591|gb|EAL20296.1| hypothetical protein CNBF1080 [Crypto... 45 0.023
gi|4323242|gb|AAD16274.1| phosphatidylinositol 3-kinase TOR1 [Cr... 45 0.023
gi|13878337|sp|Q13315|ATM_HUMAN Serine-protein kinase ATM (Ataxi... 45 0.023
gi|2304971|gb|AAB65827.1| ATM [Homo sapiens] 45 0.023
gi|1585222|prf||2124355A ATM gene 45 0.023
gi|20336203|ref|NP_000042.2| ataxia telangiectasia mutated prote... 45 0.023
gi|1497931|gb|AAB38309.1| ataxia-telangiectasia 45 0.023
gi|20336199|ref|NP_612149.1| ataxia telangiectasia mutated prote... 45 0.023
gi|1082236|pir||A43100 ataxia telangiectasia-associated protein ... 45 0.023
gi|31239405|ref|XP_320116.1| ENSANGP00000018055 [Anopheles gambi... 45 0.023
gi|586447|sp|P38110|TEL1_YEAST Telomer length regulation protein... 45 0.030
gi|6319383|ref|NP_009465.1| Protein kinase, primarily involved i... 45 0.030
gi|34015274|gb|AAQ56466.1| putative phosphatidylinositol 3-kinas... 45 0.030
gi|6636413|gb|AAF20175.1| ataxia telangiectasia mutated [Xenopus... 45 0.030
gi|46128611|ref|XP_388859.1| hypothetical protein FG08683.1 [Gib... 45 0.030
gi|50285547|ref|XP_445202.1| unnamed protein product [Candida gl... 44 0.039
gi|46122283|ref|XP_385695.1| hypothetical protein FG05519.1 [Gib... 44 0.039
gi|32403494|ref|XP_322360.1| hypothetical protein [Neurospora cr... 44 0.039
gi|46810446|gb|AAT01608.1| ataxia-telangiectasia mutated protein... 44 0.051
gi|46441069|gb|EAL00369.1| hypothetical protein CaO19.13026 [Can... 44 0.051
gi|46440946|gb|EAL00247.1| hypothetical protein CaO19.5580 [Cand... 44 0.051
gi|38099189|gb|EAA46567.1| hypothetical protein MG08910.4 [Magna... 44 0.051
gi|46431140|gb|EAK90769.1| hypothetical protein CaO19.1018 [Cand... 44 0.051
gi|16506130|dbj|BAB70696.1| phosphatidylinositol 3-kinase-relate... 44 0.067
gi|18765739|ref|NP_055907.2| PI-3-kinase-related kinase SMG-1 is... 44 0.067
gi|14289323|gb|AAK58892.1| LIP isoform of BLIP [Homo sapiens] 44 0.067
gi|50418747|ref|XP_457893.1| unnamed protein product [Debaryomyc... 44 0.067
gi|14719394|ref|NP_054725.1| PI-3-kinase-related kinase SMG-1 is... 44 0.067
gi|21666440|gb|AAM73708.1| PI-3-kinase ATX [Homo sapiens] 44 0.067
gi|20521043|dbj|BAA24851.2| KIAA0421 [Homo sapiens] 44 0.067
gi|31203585|ref|XP_310741.1| ENSANGP00000021947 [Anopheles gambi... 43 0.11
gi|11357182|pir||T51174 ataxia-telangiectasia mutated protein (A... 43 0.11
gi|7960715|emb|CAB92122.1| AtATM [Arabidopsis thaliana] 43 0.11
gi|15222149|ref|NP_175372.1| leucine-rich repeat family protein ... 43 0.11
gi|50755797|ref|XP_414907.1| PREDICTED: similar to PI-3-kinase A... 42 0.15
gi|50257945|gb|EAL20642.1| hypothetical protein CNBE3070 [Crypto... 42 0.15
gi|50308521|ref|XP_454263.1| unnamed protein product [Kluyveromy... 42 0.15
gi|34863403|ref|XP_236275.2| similar to homolog of the human ata... 42 0.19
gi|38090005|ref|XP_147046.2| similar to ataxia telangiectasia an... 41 0.33
gi|31126780|gb|AAP44699.1| putative phosphatidylinositol 3-kinas... 41 0.33
gi|50255951|gb|EAL18680.1| hypothetical protein CNBI2680 [Crypto... 41 0.33
gi|48107163|ref|XP_396177.1| similar to ataxia telangiectasia mu... 41 0.33
gi|50289131|ref|XP_446995.1| unnamed protein product [Candida gl... 40 0.74
gi|34534956|dbj|BAC87164.1| unnamed protein product [Homo sapiens] 40 0.74
gi|31230620|ref|XP_318419.1| ENSANGP00000002762 [Anopheles gambi... 40 0.97
gi|34862283|ref|XP_216844.2| similar to Splicing factor 3A subun... 39 1.3
gi|47848636|dbj|BAD22484.1| ABC1 family protein-like [Oryza sati... 39 1.3
gi|34894104|ref|NP_908377.1| AtATM like protein [Oryza sativa (j... 39 1.3
gi|48865604|ref|ZP_00319463.1| COG3853: Uncharacterized protein ... 39 1.6
gi|48106660|ref|XP_393073.1| similar to CG5373-PA [Apis mellifera] 39 2.2
gi|45478104|gb|AAS66223.1| LRRG00132 [Rattus norvegicus] 38 2.8
gi|26350441|dbj|BAC38860.1| unnamed protein product [Mus musculus] 38 2.8
gi|283699|pir||A42091 transcription activator SNF2/SWI2 homolog ... 38 3.7
gi|39586345|emb|CAE74002.1| Hypothetical protein CBG21638 [Caeno... 38 3.7
gi|17985967|ref|NP_536746.1| CG5942-PA [Drosophila melanogaster]... 38 3.7
gi|34783328|gb|AAH22049.1| Unknown (protein for IMAGE:4291567) [... 38 3.7
gi|34868150|ref|XP_343327.1| similar to myeloid/lymphoid or mixe... 37 4.8
gi|24664907|ref|NP_730088.1| CG5942-PD [Drosophila melanogaster]... 37 4.8
gi|21309886|gb|AAM46085.1| putative regulatory protein [Candida ... 37 4.8
gi|6648182|gb|AAF21180.1| unknown protein [Arabidopsis thaliana] 37 6.3
gi|15983801|gb|AAL10497.1| At3g07700/F17A17.4 [Arabidopsis thali... 37 6.3
gi|18398032|ref|NP_566315.1| ABC1 family protein [Arabidopsis th... 37 6.3
gi|21618050|gb|AAM67100.1| unknown [Arabidopsis thaliana] 37 6.3
gi|6466953|gb|AAF13088.1| unknown protein [Arabidopsis thaliana] 37 6.3
gi|19424003|gb|AAL87300.1| unknown protein [Arabidopsis thaliana] 37 6.3
gi|45915277|ref|ZP_00197032.1| COG0248: Exopolyphosphatase [Meso... 37 8.2
gi|48103175|ref|XP_395516.1| similar to SI:bZ1P14.5 (novel prote... 37 8.2
gi|21361376|ref|NP_009096.2| splicing factor 3a, subunit 2, 66kD... 37 8.2
gi|627605|pir||A47655 spliceosome-associated protein SAP 62 - hu... 37 8.2
>gi|17556524|ref|NP_499596.1| type 3 phosphatidylinositol (3N342)
[Caenorhabditis elegans]
gi|7510482|pir||T27406 hypothetical protein Y75B8A.24 -
Caenorhabditis elegans
gi|3980040|emb|CAA22108.1| Hypothetical protein Y75B8A.24
[Caenorhabditis elegans]
Length = 2121
Score = 3987 bits (10340), Expect = 0.0
Identities = 2034/2121 (95%), Positives = 2034/2121 (95%)
Frame = -1
Query: 6366 MRDIEDFVFTNKQCLAICIAQVSFWARNSIKIEFFQNENTKLSQIFNLLALDDKEEQFEA 6187
MRDIEDFVFTNKQCLAICIAQVSFWARNSIKIEFFQNENTKLSQIFNLLALDDKEEQFEA
Sbjct: 1 MRDIEDFVFTNKQCLAICIAQVSFWARNSIKIEFFQNENTKLSQIFNLLALDDKEEQFEA 60
Query: 6186 QPLSHNVRCSLIAIANYLLHSHGQHADELVPMLLRALIALPHMKWIDDGLLNKSDKIPIQ 6007
QPLSHNVRCSLIAIANYLLHSHGQHADELVPMLLRALIALPHMKWIDDGLLNKSDKIPIQ
Sbjct: 61 QPLSHNVRCSLIAIANYLLHSHGQHADELVPMLLRALIALPHMKWIDDGLLNKSDKIPIQ 120
Query: 6006 EQFSFCFNTSLSDLAAHLPRFRQQIVSAQADALACAVSSIYDVLEDQESLEHNYSHVIKL 5827
EQFSFCFNTSLSDLAAHLPRFRQQIVSAQADALACAVSSIYDVLEDQESLEHNYSHVIKL
Sbjct: 121 EQFSFCFNTSLSDLAAHLPRFRQQIVSAQADALACAVSSIYDVLEDQESLEHNYSHVIKL 180
Query: 5826 MCYALGLLRSIGRFSADYDTPLISLIFPLPVDETKKCKGAGGADIKHRISSDEFTFDTSC 5647
MCYALGLLRSIGRFSADYDTPLISLIFPLPVDETKKCKGAGGADIKHRISSDEFTFDTSC
Sbjct: 181 MCYALGLLRSIGRFSADYDTPLISLIFPLPVDETKKCKGAGGADIKHRISSDEFTFDTSC 240
Query: 5646 DASSSDPLLLTDSKSSRLIRMYNKLGASFLLNNYTGGLKLTMSSEDLEKLFDSVQRLMDS 5467
DASSSDPLLLTDSKSSRLIRMYNKLGASFLLNNYTGGLKLTMSSEDLEKLFDSVQRLMDS
Sbjct: 241 DASSSDPLLLTDSKSSRLIRMYNKLGASFLLNNYTGGLKLTMSSEDLEKLFDSVQRLMDS 300
Query: 5466 KFLESLDXXXXXXXXXXXGVKRNPYKSMSEITNLCCLTLLKDVLGPYSVKNSDKNQENCG 5287
KFLESLD GVKRNPYKSMSEITNLCCLTLLKDVLGPYSVKNSDKNQENCG
Sbjct: 301 KFLESLDEISGEIFSGGSGVKRNPYKSMSEITNLCCLTLLKDVLGPYSVKNSDKNQENCG 360
Query: 5286 NSLQEASPSSPISEKFAKEISIFSKTALSKLDAXXXXXXXXXXXXXXXXXSRQKLNIQSA 5107
NSLQEASPSSPISEKFAKEISIFSKTALSKLDA SRQKLNIQSA
Sbjct: 361 NSLQEASPSSPISEKFAKEISIFSKTALSKLDAELSSLQHSSESSLSTEVSRQKLNIQSA 420
Query: 5106 TVCLQLXXXXXXXXXXXXXICTEIIVRLFANQTQKTIISQLPLYLKAISSMATLAEKFPA 4927
TVCLQL ICTEIIVRLFANQTQKTIISQLPLYLKAISSMATLAEKFPA
Sbjct: 421 TVCLQLIAWAAIDDMDADAICTEIIVRLFANQTQKTIISQLPLYLKAISSMATLAEKFPA 480
Query: 4926 VATTAVIQNLQRFLLEPAPMLTKLASDSTLERGKSAGDVIQHSKSSNNLIDAITKRKLSL 4747
VATTAVIQNLQRFLLEPAPMLTKLASDSTLERGKSAGDVIQHSKSSNNLIDAITKRKLSL
Sbjct: 481 VATTAVIQNLQRFLLEPAPMLTKLASDSTLERGKSAGDVIQHSKSSNNLIDAITKRKLSL 540
Query: 4746 DALRNSAIKAICRALKSSIRMESDSVQQCLAGLSTKLFVCSNANNFVVSLVCENAIQTLG 4567
DALRNSAIKAICRALKSSIRMESDSVQQCLAGLSTKLFVCSNANNFVVSLVCENAIQTLG
Sbjct: 541 DALRNSAIKAICRALKSSIRMESDSVQQCLAGLSTKLFVCSNANNFVVSLVCENAIQTLG 600
Query: 4566 GIGVGLVDSTAVEVPEMVVQIYLQRFANPPSQLDVTMIRCLAEMWIAGARSIYENVWKLF 4387
GIGVGLVDSTAVEVPEMVVQIYLQRFANPPSQLDVTMIRCLAEMWIAGARSIYENVWKLF
Sbjct: 601 GIGVGLVDSTAVEVPEMVVQIYLQRFANPPSQLDVTMIRCLAEMWIAGARSIYENVWKLF 660
Query: 4386 TQICIESSNRVYSQGNNESNDQRYTHVSLAVDVAMSRMAAGVANEDDKMTXXXXXXXXXX 4207
TQICIESSNRVYSQGNNESNDQRYTHVSLAVDVAMSRMAAGVANEDDKMT
Sbjct: 661 TQICIESSNRVYSQGNNESNDQRYTHVSLAVDVAMSRMAAGVANEDDKMTLLVRLLELFV 720
Query: 4206 XLGIEGRRVGEXXXXXXXXXXXSAGNLGVLMPKIASLLRRMQPISEPTTKLRSLFRDFWF 4027
LGIEGRRVGE SAGNLGVLMPKIASLLRRMQPISEPTTKLRSLFRDFWF
Sbjct: 721 QLGIEGRRVGEKVSKSTVKMSTSAGNLGVLMPKIASLLRRMQPISEPTTKLRSLFRDFWF 780
Query: 4026 YCTVLGFDVESSSLWPEEWYNAVCETATKTPVLIATENLRSELIDNAAIRSDSISPQELQ 3847
YCTVLGFDVESSSLWPEEWYNAVCETATKTPVLIATENLRSELIDNAAIRSDSISPQELQ
Sbjct: 781 YCTVLGFDVESSSLWPEEWYNAVCETATKTPVLIATENLRSELIDNAAIRSDSISPQELQ 840
Query: 3846 EMRNTVLAELSHQAEAVPLINRFDFANCTYLLSVHRMETMRLIHANHVDAFSSFFKYIED 3667
EMRNTVLAELSHQAEAVPLINRFDFANCTYLLSVHRMETMRLIHANHVDAFSSFFKYIED
Sbjct: 841 EMRNTVLAELSHQAEAVPLINRFDFANCTYLLSVHRMETMRLIHANHVDAFSSFFKYIED 900
Query: 3666 KTMRKDKSGLWTCMLAAAPRIFLEWCEKMMKRRDNDEPTEEALVWHAQFLLFKFNHHLRE 3487
KTMRKDKSGLWTCMLAAAPRIFLEWCEKMMKRRDNDEPTEEALVWHAQFLLFKFNHHLRE
Sbjct: 901 KTMRKDKSGLWTCMLAAAPRIFLEWCEKMMKRRDNDEPTEEALVWHAQFLLFKFNHHLRE 960
Query: 3486 VRKVADACLSQLVKAFPYLLWNTKVLTTILRLLQELEDNLQKDPTCREPQFTIEGFGGWT 3307
VRKVADACLSQLVKAFPYLLWNTKVLTTILRLLQELEDNLQKDPTCREPQFTIEGFGGWT
Sbjct: 961 VRKVADACLSQLVKAFPYLLWNTKVLTTILRLLQELEDNLQKDPTCREPQFTIEGFGGWT 1020
Query: 3306 IQLQDSIEGRRSVVKDFSMRVKQILKEALRWAPASTHSNLLEYVSKFGSERDAAMQLAID 3127
IQLQDSIEGRRSVVKDFSMRVKQILKEALRWAPASTHSNLLEYVSKFGSERDAAMQLAID
Sbjct: 1021 IQLQDSIEGRRSVVKDFSMRVKQILKEALRWAPASTHSNLLEYVSKFGSERDAAMQLAID 1080
Query: 3126 ATSEGSGKSGSYLTSLYKRSNYLGQVKGMLATTLSGDIDQVTAENQLIDRLEKDFQRACK 2947
ATSEGSGKSGSYLTSLYKRSNYLGQVKGMLATTLSGDIDQVTAENQLIDRLEKDFQRACK
Sbjct: 1081 ATSEGSGKSGSYLTSLYKRSNYLGQVKGMLATTLSGDIDQVTAENQLIDRLEKDFQRACK 1140
Query: 2946 SGKDMEMEQAVLLLTALFVSLRSLNERILSLLVRTPLLNFTESTVSLCTMAWNWLLSARP 2767
SGKDMEMEQAVLLLTALFVSLRSLNERILSLLVRTPLLNFTESTVSLCTMAWNWLLSARP
Sbjct: 1141 SGKDMEMEQAVLLLTALFVSLRSLNERILSLLVRTPLLNFTESTVSLCTMAWNWLLSARP 1200
Query: 2766 EAHSLFLHEQARAFADSSRFGLGLFEKEVVGGSPLCQKLERPPPSANFRPHREWIEFIGE 2587
EAHSLFLHEQARAFADSSRFGLGLFEKEVVGGSPLCQKLERPPPSANFRPHREWIEFIGE
Sbjct: 1201 EAHSLFLHEQARAFADSSRFGLGLFEKEVVGGSPLCQKLERPPPSANFRPHREWIEFIGE 1260
Query: 2586 RCDVASYSSREQLDVLEMMFSQTLSAHIGTGHLHGSTACSNPASLAGPSRKETINQVTRG 2407
RCDVASYSSREQLDVLEMMFSQTLSAHIGTGHLHGSTACSNPASLAGPSRKETINQVTRG
Sbjct: 1261 RCDVASYSSREQLDVLEMMFSQTLSAHIGTGHLHGSTACSNPASLAGPSRKETINQVTRG 1320
Query: 2406 IEAVGVRFRLLSCVLGMVQQDACLLRPTNVLIRQRVYSCAFHYFTIAPQGPTQPEERLRE 2227
IEAVGVRFRLLSCVLGMVQQDACLLRPTNVLIRQRVYSCAFHYFTIAPQGPTQPEERLRE
Sbjct: 1321 IEAVGVRFRLLSCVLGMVQQDACLLRPTNVLIRQRVYSCAFHYFTIAPQGPTQPEERLRE 1380
Query: 2226 DIRLLTRFFEHLKNDKHYMQKEALAKTDKNLVMSSTMSQMQTNFEKSLLISXXXXXXXXX 2047
DIRLLTRFFEHLKNDKHYMQKEALAKTDKNLVMSSTMSQMQTNFEKSLLIS
Sbjct: 1381 DIRLLTRFFEHLKNDKHYMQKEALAKTDKNLVMSSTMSQMQTNFEKSLLISGTPVTATAA 1440
Query: 2046 XXXXTSLMLPPSTNYANTLTLSSQKSMAATSASIRSGKSIETKLSIEEDRRIKTWMKQRN 1867
TSLMLPPSTNYANTLTLSSQKSMAATSASIRSGKSIETKLSIEEDRRIKTWMKQRN
Sbjct: 1441 GTPNTSLMLPPSTNYANTLTLSSQKSMAATSASIRSGKSIETKLSIEEDRRIKTWMKQRN 1500
Query: 1866 MLMLLVANEIERLSAWLHPLALAQEDCALDSEEFLRGAFTQAKATGGEKNIWREQAQLAW 1687
MLMLLVANEIERLSAWLHPLALAQEDCALDSEEFLRGAFTQAKATGGEKNIWREQAQLAW
Sbjct: 1501 MLMLLVANEIERLSAWLHPLALAQEDCALDSEEFLRGAFTQAKATGGEKNIWREQAQLAW 1560
Query: 1686 DISPELAIQLPSRFRGSPELVKYVDVLVRGQPEPVAHIPEALPLFLGNGSTVFETSDMSH 1507
DISPELAIQLPSRFRGSPELVKYVDVLVRGQPEPVAHIPEALPLFLGNGSTVFETSDMSH
Sbjct: 1561 DISPELAIQLPSRFRGSPELVKYVDVLVRGQPEPVAHIPEALPLFLGNGSTVFETSDMSH 1620
Query: 1506 VLTWARCSPVMALSLLTPRIYPMHPISMQYAVRVLRSYSADELLLYIPQIVQAVRYDTMG 1327
VLTWARCSPVMALSLLTPRIYPMHPISMQYAVRVLRSYSADELLLYIPQIVQAVRYDTMG
Sbjct: 1621 VLTWARCSPVMALSLLTPRIYPMHPISMQYAVRVLRSYSADELLLYIPQIVQAVRYDTMG 1680
Query: 1326 YISELIIWLAGHSQLLSHQLIWNMQTNMFTDEESKVKDPVLFEALNDIMQKILSQLEGAA 1147
YISELIIWLAGHSQLLSHQLIWNMQTNMFTDEESKVKDPVLFEALNDIMQKILSQLEGAA
Sbjct: 1681 YISELIIWLAGHSQLLSHQLIWNMQTNMFTDEESKVKDPVLFEALNDIMQKILSQLEGAA 1740
Query: 1146 RRFHEAEFKLFHQLTAISGTIKPFPKGDARKKACLKALADVKIETITYLPSNPEAVLLDL 967
RRFHEAEFKLFHQLTAISGTIKPFPKGDARKKACLKALADVKIETITYLPSNPEAVLLDL
Sbjct: 1741 RRFHEAEFKLFHQLTAISGTIKPFPKGDARKKACLKALADVKIETITYLPSNPEAVLLDL 1800
Query: 966 DYSSGTPMQSAAKAPFLARFRVKRCGVRELEHIGLQAQSEHGGKTTEADLEELKKVQDSR 787
DYSSGTPMQSAAKAPFLARFRVKRCGVRELEHIGLQAQSEHGGKTTEADLEELKKVQDSR
Sbjct: 1801 DYSSGTPMQSAAKAPFLARFRVKRCGVRELEHIGLQAQSEHGGKTTEADLEELKKVQDSR 1860
Query: 786 VCWQAAIFKVGDDVRXXXXXXXXXXXMKNVWAGLGLPVRVFPYRVVATSPGCGVIECVPN 607
VCWQAAIFKVGDDVR MKNVWAGLGLPVRVFPYRVVATSPGCGVIECVPN
Sbjct: 1861 VCWQAAIFKVGDDVRQDMLALQLMQLMKNVWAGLGLPVRVFPYRVVATSPGCGVIECVPN 1920
Query: 606 SKSRDQLGRQTDFGLYEYFKTQYGDESSETFQEARRNFVRSMAAYSVFSFLLQIKDRHNG 427
SKSRDQLGRQTDFGLYEYFKTQYGDESSETFQEARRNFVRSMAAYSVFSFLLQIKDRHNG
Sbjct: 1921 SKSRDQLGRQTDFGLYEYFKTQYGDESSETFQEARRNFVRSMAAYSVFSFLLQIKDRHNG 1980
Query: 426 NIMIDLDGHIIHIDFGFMFESSPGGNLGFEPDFKLSEEMVAIMGGKMEAAPFRQFASLCV 247
NIMIDLDGHIIHIDFGFMFESSPGGNLGFEPDFKLSEEMVAIMGGKMEAAPFRQFASLCV
Sbjct: 1981 NIMIDLDGHIIHIDFGFMFESSPGGNLGFEPDFKLSEEMVAIMGGKMEAAPFRQFASLCV 2040
Query: 246 HAYLAVRPYHKSFVSLVSLMLDTHLPCFRGKTINQLRARFAPEMNEKDAAKYMYSVITNC 67
HAYLAVRPYHKSFVSLVSLMLDTHLPCFRGKTINQLRARFAPEMNEKDAAKYMYSVITNC
Sbjct: 2041 HAYLAVRPYHKSFVSLVSLMLDTHLPCFRGKTINQLRARFAPEMNEKDAAKYMYSVITNC 2100
Query: 66 FLNIRSKMYDQLQYFQNEIPY 4
FLNIRSKMYDQLQYFQNEIPY
Sbjct: 2101 FLNIRSKMYDQLQYFQNEIPY 2121
>gi|39583262|emb|CAE60054.1| Hypothetical protein CBG03566
[Caenorhabditis briggsae]
Length = 2098
Score = 3400 bits (8816), Expect = 0.0
Identities = 1755/2147 (81%), Positives = 1872/2147 (86%), Gaps = 26/2147 (1%)
Frame = -1
Query: 6366 MRDIEDFVFTNKQCLAICIAQVSFWARNSIKIEFFQNENTKLSQIFNLLALDDKEEQFEA 6187
MRDIEDFVFTNKQCLA+CIA+ NENTKLSQI+ LLALDDKEE FE+
Sbjct: 1 MRDIEDFVFTNKQCLAVCIAK---------------NENTKLSQIYQLLALDDKEEHFES 45
Query: 6186 QPLSHNVRCSLIAIANYLLHSHGQHADELVPMLLRALIALPHMKWIDDGLLNKSDKIPIQ 6007
QPLSHNVRCSLI +AN+LLHSHG+ AD+LVPMLLRAL ALPHMKWIDDGLLNKSD+IP+Q
Sbjct: 46 QPLSHNVRCSLIGVANFLLHSHGRFADDLVPMLLRALTALPHMKWIDDGLLNKSDRIPVQ 105
Query: 6006 EQFSFCFNTSLSDLAAHLPRFRQQIVSAQADALACAVSSIYDVLEDQESLEHNYSHVIKL 5827
EQF+FCFNTSLSDLAAHLPR R+ IVSAQ DALAC+VSS+YD+LED+E+LEHNYSH+IKL
Sbjct: 106 EQFAFCFNTSLSDLAAHLPRLREHIVSAQCDALACSVSSVYDLLEDKENLEHNYSHIIKL 165
Query: 5826 MCYALGLLRSIGRFSADYDTPLISLIFPLPVDETKKCKGAGGADIKHRISSDEFTFDTSC 5647
MCY LGL RSIGRFS DYDTPLISLIFPLP+DETKK KG +I HRIS+DEFTFDT
Sbjct: 166 MCYVLGLTRSIGRFSTDYDTPLISLIFPLPMDETKKLKGTSSGEIIHRISTDEFTFDTPE 225
Query: 5646 DASSSDPLLLTDSKSSRLIRMYNKLGASFLLNNYTGGLKLTMSSEDLEKLFDSVQRLMDS 5467
++ + LL D +RLIRMYNKLGASFL +N+TGGLKL MS++DLEKLFDSVQRLMDS
Sbjct: 226 NSEN----LLRDQ--TRLIRMYNKLGASFLFHNFTGGLKLEMSAQDLEKLFDSVQRLMDS 279
Query: 5466 KFLESLDXXXXXXXXXXXGVKRNPYKSMSEITNLCCLTLLKDVLGPYSVKNSDKNQENCG 5287
KFLE LD VKRNPYKSMSEI NLC LTLLKDVLGPY
Sbjct: 280 KFLEVLDEISGEIFQSGGAVKRNPYKSMSEIVNLCSLTLLKDVLGPY------------- 326
Query: 5286 NSLQEASPSSPISEKFAKEISIFSKTALSKLDAXXXXXXXXXXXXX--XXXXSRQKLNIQ 5113
+KFAKEI +FSK AL KLD+ SRQKLN+Q
Sbjct: 327 -------------QKFAKEIGVFSKAALQKLDSELQGLQHSSEPVMNPTTEVSRQKLNMQ 373
Query: 5112 SATVCLQLXXXXXXXXXXXXXICTEIIVRLFANQTQKTIISQLPLYLKAISSMATLAEKF 4933
SATV LQL ICTEII RLFANQ Q+TIISQLPLYLKAISSMATLAEKF
Sbjct: 374 SATVSLQLIAWAAVDDIDADTICTEIITRLFANQPQRTIISQLPLYLKAISSMATLAEKF 433
Query: 4932 PAVATTAVIQNLQRFLLEPAPMLTKLASD-STLERGKSAGDVIQHSKSSNNLIDAITKRK 4756
PAVATTAV QNLQRFLLEPAPMLTKLASD STLERGKSA DVIQ+SKSS+N I+AI+KRK
Sbjct: 434 PAVATTAVNQNLQRFLLEPAPMLTKLASDTSTLERGKSAEDVIQNSKSSSN-IEAISKRK 492
Query: 4755 LSLDALRNSAIKAICRALKSSIRMESDSVQQCLAGLSTKLFVCSNANNFVVSLVCENAIQ 4576
L+LDALRN+AIKAICRALKSSIRMESDSVQQCLAGLSTKLFVCSNA NFVVSLVCENAIQ
Sbjct: 493 LALDALRNAAIKAICRALKSSIRMESDSVQQCLAGLSTKLFVCSNAQNFVVSLVCENAIQ 552
Query: 4575 TLGGIGVGLVDSTAVEVPEMVVQIYLQRFANPPSQLDVTMIRCLAEMWIAGARSIYENVW 4396
TLGGIGVGLVDSTAVEVPEMVVQIYLQRFANPPSQLDVTMIRCLAEMWIAGARSIYENVW
Sbjct: 553 TLGGIGVGLVDSTAVEVPEMVVQIYLQRFANPPSQLDVTMIRCLAEMWIAGARSIYENVW 612
Query: 4395 KLFTQICIESSNRVYSQGNNESNDQRYTHVSLAVDVAMSRMAAGVANEDDKMTXXXXXXX 4216
KLFTQICIESSNRVYSQGNN+SNDQRYTHVSLAVD+AMSRMA V NEDDKMT
Sbjct: 613 KLFTQICIESSNRVYSQGNNDSNDQRYTHVSLAVDMAMSRMAVSVKNEDDKMTLLVRLLE 672
Query: 4215 XXXXLGIEGRRVGE--------------XXXXXXXXXXXSAGNLGVLMPKIASLLRRMQP 4078
LGIEGRRVGE SAGNLGVLMPKIASLLRRMQP
Sbjct: 673 LFVQLGIEGRRVGEKVSKSTVKLTIVALSTSVNSVKMSTSAGNLGVLMPKIASLLRRMQP 732
Query: 4077 ISEPTTKLRSLFRDFWFYCTVLGFDVESSSLWPEEWYNAVCETATKTPVLIATENLRSEL 3898
ISEPT KLRSLFRDFWFYCTVLGFDVESSSLWPEEWYNAVCETATKTPVLIA+ENLRSEL
Sbjct: 733 ISEPTPKLRSLFRDFWFYCTVLGFDVESSSLWPEEWYNAVCETATKTPVLIASENLRSEL 792
Query: 3897 IDNAAIRSDSISPQELQEMRNTVLAELSHQAEAVPLINRFDFANCTYLLSVHRMETMRLI 3718
IDNAAIRSDSISPQELQEMRNTVLAELSHQ+EAVPLINRFDFANCTYLLSVHRME+MRLI
Sbjct: 793 IDNAAIRSDSISPQELQEMRNTVLAELSHQSEAVPLINRFDFANCTYLLSVHRMESMRLI 852
Query: 3717 HANHVDAFSSFFKYIEDKTMRKDKSGLWTCMLAAAPRIFLEWCEKMMKRRDNDEPTEEAL 3538
HANHVDAFSSFFKYIEDKT+RKDKSGLWTCMLAAAPRIF WC KMMKRRDNDEPTEEAL
Sbjct: 853 HANHVDAFSSFFKYIEDKTVRKDKSGLWTCMLAAAPRIFWTWCGKMMKRRDNDEPTEEAL 912
Query: 3537 VWHAQFLLFKFNHHLREVRKVADACLSQLVKAFPYLLWNTKVLTTILRLLQELEDNLQKD 3358
VWHAQFLLFKFNHHLREVRKVADACLSQLVKAFPYLLWNTKVLTTILRLLQELEDNLQKD
Sbjct: 913 VWHAQFLLFKFNHHLREVRKVADACLSQLVKAFPYLLWNTKVLTTILRLLQELEDNLQKD 972
Query: 3357 PTCREPQFTIEGFG-GWTIQLQDSIEGRRSVVKDFSMRVKQILKEALRWAPASTHSNLLE 3181
PTC+EPQFT++GF GWTIQLQDSIEGRRSVVKDFSMRVKQILKEAL+WAPASTHSNLLE
Sbjct: 973 PTCKEPQFTMDGFEKGWTIQLQDSIEGRRSVVKDFSMRVKQILKEALQWAPASTHSNLLE 1032
Query: 3180 YVSKFGSERDAAMQLAIDATSEGS-GKSGSYLTSLYKRSNYLGQVKGMLATTLSGDIDQV 3004
YVSKFG+ERDAAMQLAIDATSEG GKSGSYLTSLYKRSNYLGQVKGMLATTLSGDIDQV
Sbjct: 1033 YVSKFGAERDAAMQLAIDATSEGGKGKSGSYLTSLYKRSNYLGQVKGMLATTLSGDIDQV 1092
Query: 3003 TAENQLIDRLEKDFQRACKSGKDMEMEQAVLLLTALFVSLRSLNERILSLLVRTPLLNFT 2824
TAEN LIDRLEKDFQRACKSGKD EMEQAVLLLTALFVSLRS+NERIL+LLVRTPL NFT
Sbjct: 1093 TAENSLIDRLEKDFQRACKSGKDNEMEQAVLLLTALFVSLRSMNERILTLLVRTPLHNFT 1152
Query: 2823 ESTVSLCTMAWNWLLSARPEAHSLFLHEQARAFADSSRFGLGLFEKEVVGGS--PLCQKL 2650
EST+SLCTMAWNWLLSARPEAHSLFLHEQARAFADS RFGLGLFEKE V S PLC+++
Sbjct: 1153 ESTISLCTMAWNWLLSARPEAHSLFLHEQARAFADSCRFGLGLFEKEHVDMSLSPLCRQV 1212
Query: 2649 ERPPPSANFRPHREWIEFIGERCDVASYSSREQLDVLEMMFSQTLSAHIGTGHLHGSTAC 2470
ERPPPSANFRPHREWIEFIGERCDVASYSSREQLDVLEMMF+QTLSA IGTGHLHGST
Sbjct: 1213 ERPPPSANFRPHREWIEFIGERCDVASYSSREQLDVLEMMFAQTLSAQIGTGHLHGSTVV 1272
Query: 2469 SNPASLAGPSRKETINQVTRGIEAVGVRFRLLSCVLGMVQQDACLLRPTNVLIRQRVYSC 2290
+N +L GP+RKE+INQVTRGIEAVGVRFRLLSCVLGM+QQDACLLRPTN+LIRQRVYS
Sbjct: 1273 NNIGNLTGPTRKESINQVTRGIEAVGVRFRLLSCVLGMIQQDACLLRPTNLLIRQRVYSS 1332
Query: 2289 AFHYFTIAPQGPTQPEERLREDIRLLTRFFEHLKNDKHYMQKEALAKTDKNLVMSSTMSQ 2110
AFHYFTIAPQGPTQ E+ LREDI+LL +FF+HL+NDK+YM KE +AK DKN+ +++TMS
Sbjct: 1333 AFHYFTIAPQGPTQGEDALREDIKLLAKFFDHLQNDKYYMVKETMAKNDKNVGLATTMSH 1392
Query: 2109 MQTNFEKSLLISXXXXXXXXXXXXXTSLMLPPSTNYANTLTLSSQKSMAATSASIRSGKS 1930
MQT FEKSLL+S +LMLPP+TNYANTLTLSSQK+MAA +AS++SGK+
Sbjct: 1393 MQTAFEKSLLVSGTGAATTTGTPTAATLMLPPTTNYANTLTLSSQKAMAAATASMKSGKT 1452
Query: 1929 IETKLSIEEDRRIKTWMKQRNMLMLLVANEIERLSAWLHPLALAQEDCALDSEEFLRGAF 1750
IE KL+IEE++RI ++KQR++LMLLVANEIERLSAWLHPLAL QEDC + SE+FLR
Sbjct: 1453 IEAKLTIEENKRINVYLKQRHILMLLVANEIERLSAWLHPLALGQEDCTIVSEQFLRTTI 1512
Query: 1749 TQ-----AKATGGEKNIWREQAQLAWDISPELAIQLPSRFRGSPELVKYVDVLVRGQPEP 1585
+ ++ W++ A +AW ISPELAIQLPSRFRG +L V+ LVR QPE
Sbjct: 1513 AEIVGAVVNPENKKRKCWKDPADIAWSISPELAIQLPSRFRGYQDLADAVERLVRLQPEL 1572
Query: 1584 VAHIPEALPLFLGNGSTVFETSDMSHVLTWARCSPVMALSLLTPRIYPMHPISMQYAVRV 1405
VAHIPEALPLFL NG VFET++MSHVLTWARCSPVMALSLLTPR Y +HPISMQYAVRV
Sbjct: 1573 VAHIPEALPLFL-NGGHVFETAEMSHVLTWARCSPVMALSLLTPRQYSIHPISMQYAVRV 1631
Query: 1404 LRSYSADELLLYIPQIVQAVRYDTMGYISELIIWLAGHSQLLSHQLIWNMQTNMFTDEES 1225
LRSY AD LL+YIPQIVQ+VRYDTMGYI+EL+IWLAGHSQLL+HQLIWNMQTNM+TDE+S
Sbjct: 1632 LRSYPADALLMYIPQIVQSVRYDTMGYIAELMIWLAGHSQLLAHQLIWNMQTNMYTDEDS 1691
Query: 1224 KVKDPVLFEALNDIMQKILSQLEGAARRFHEAEFKLFHQLTAISGTIKPFPKGDARKKAC 1045
K KDPVLFE LNDIMQ+I+SQLEGAARRFHEAEFKLFHQLTAISGTIKPFPKGDARKKAC
Sbjct: 1692 KTKDPVLFEPLNDIMQRIMSQLEGAARRFHEAEFKLFHQLTAISGTIKPFPKGDARKKAC 1751
Query: 1044 LKALADVKIETITYLPSNPEAVLLDLDYSSGTPMQSAAKAPFLARFRVKRCGVRELEHIG 865
LKALADVKIETITYLPSNPEAVLLDLDYSSGTPMQSAAKAPFLARFRVKRCGVRELEHIG
Sbjct: 1752 LKALADVKIETITYLPSNPEAVLLDLDYSSGTPMQSAAKAPFLARFRVKRCGVRELEHIG 1811
Query: 864 LQAQSEHGGKTTEADLEELKKVQDSRVCWQAAIFKVGDDVRXXXXXXXXXXXMKNVWAGL 685
LQAQSE GK++EADLE L+KVQDSRVCWQAAIFKVGDDVR MKNVWAGL
Sbjct: 1812 LQAQSEKEGKSSEADLETLRKVQDSRVCWQAAIFKVGDDVRQDMLALQLMQLMKNVWAGL 1871
Query: 684 GLPVRVFPYRVVATSPGCGVIECVPNSKSRDQLGRQTDFGLYEYFKTQYGDESSETFQEA 505
GLPVRVFPYRVVATSPGCGVIECVPNSKSRDQLGRQTDFGLYEYFKTQYGDESSETFQEA
Sbjct: 1872 GLPVRVFPYRVVATSPGCGVIECVPNSKSRDQLGRQTDFGLYEYFKTQYGDESSETFQEA 1931
Query: 504 RRNFVRSMAAYSVFSFLLQIKDRHNGNIMIDLDGHIIHIDFGFMFESSPGGNLGFEPDFK 325
RRNFVRSMAAYSVFSFLLQIKDRHNGNIMIDLDGHIIHIDFGFMFESSPGGNLGFEPDFK
Sbjct: 1932 RRNFVRSMAAYSVFSFLLQIKDRHNGNIMIDLDGHIIHIDFGFMFESSPGGNLGFEPDFK 1991
Query: 324 LSEEMVAIMGGKMEAAPFRQFASLCVHAYLAVRPYHKSFVSLVSLMLDTHLPCFRGKTIN 145
LSEEMVAIMGGKMEAAPFRQFASLCVHAYLAVRPYHKSFVSLVSLMLDTHLPCFRGKTI
Sbjct: 1992 LSEEMVAIMGGKMEAAPFRQFASLCVHAYLAVRPYHKSFVSLVSLMLDTHLPCFRGKTIQ 2051
Query: 144 QLRARFAPEMNEKDAAKYMYSVITNCFLNIRSKMYDQLQYFQNEIPY 4
QLR RFAP+MNEKDAAKYM+SVITNCFLNIRSKMYDQLQYFQNEIPY
Sbjct: 2052 QLRTRFAPDMNEKDAAKYMHSVITNCFLNIRSKMYDQLQYFQNEIPY 2098
>gi|50416360|gb|AAH77604.1| Unknown (protein for MGC:84514) [Xenopus
laevis]
Length = 2061
Score = 1277 bits (3304), Expect = 0.0
Identities = 801/2151 (37%), Positives = 1165/2151 (53%), Gaps = 92/2151 (4%)
Frame = -1
Query: 6180 LSHNVRCSLIAIANYLLHSHGQHADELVPMLLRALIALPHMKWIDDGLLNKSD-KIPIQE 6004
L R +LIA+ +L+ S QH + +VP LL+ L LP ++WI++ K +P+ E
Sbjct: 12 LDERRRDALIALGIFLVESDLQHKESVVPYLLKLLRGLPKVQWIEESNSRKGKGTLPVAE 71
Query: 6003 QFSFCFNTSLSDLAAHLPRFRQQIVSAQADALACAVSSIYDVLEDQESLEHNYSHVIKLM 5824
FSFC T LSD+A FR QI+ D + C + + + + + Y +
Sbjct: 72 TFSFCLVTLLSDVAHRDQAFRGQILETLMDVMQCLLG----MCQSPQIQDKEYLCKYAVP 127
Query: 5823 CYALGLLRSIGRFSADYDTPLISLIFP---------------------------LPVDET 5725
C +G+ R+ GR+S + + L+S +FP LP
Sbjct: 128 CL-IGISRAFGRYS-NTEESLLSKLFPKVSPQSLKAPEELEGIRRRSFNDFRSILPSSLL 185
Query: 5724 KKCKG------AGGADIKHRISSDEFTFDTSCDASSSDPLL----LTDSKSSRLIRMYNK 5575
C+G ++S D A S+ P L D +
Sbjct: 186 TVCQGDSLKRKTSSVSSGSQVSPDHIVPPPGSPAGSTIPYFEGSYLPDGSAVDPDYYLTT 245
Query: 5574 LGASFLLNNYTGGLK---LTMSSEDLEKLFDSVQRLMDSKFLESLDXXXXXXXXXXXGVK 5404
+ +SF ++ G+ M + L +L V++++ FL SLD V
Sbjct: 246 ISSSFSVSPLFTGVNNKDFDMPQDILRQLLHMVKQIVTDLFLSSLDMLIAEITEANASVN 305
Query: 5403 RNPYKSMSEITNLCCLTLLKDVLGPYSVKNSDKN--QENCGNSLQEASPSSPISEKFAKE 5230
YK+ S+ + +L+D L Y+VK+ + +E L++ + S +K +
Sbjct: 306 LY-YKTFSDPLYVAMFKMLRDTL--YNVKDPHTSFVKEIHDFVLEQFNSSQGELQKILHD 362
Query: 5229 ISIFSKTALSKLDAXXXXXXXXXXXXXXXXXSRQKLNIQSATVCLQLXXXXXXXXXXXXX 5050
+ + LS L KL Q+ C+ L
Sbjct: 363 MDRVNNE-LSPL----------------------KLRCQANAACVDLMVWAVKDEQGAEN 399
Query: 5049 ICTEIIVRLFANQTQKTIISQLPLYLKAISSMATLAEKFPAVATTAVIQNLQRFLLEPAP 4870
+C + +L + + K II+ +PL + + + L E+FP V + V +L+ FL+ P+P
Sbjct: 400 LCIRLSEKLQSKTSSKVIIAHMPLLICCLQGLGRLCERFPVVVHS-VTPSLRDFLVIPSP 458
Query: 4869 MLTKLAS-DSTLERGKSAGDVI-----QHSKSSNNLIDAITKRKLSLDALRNSAIKAICR 4708
+L KL S + G A D+ +HS+S+ +++ + + LR+ AI ICR
Sbjct: 459 VLVKLYKYHSQYQTG--ANDIKISVTNEHSESTMSIMSGKKSQASMYEQLRDIAIDNICR 516
Query: 4707 ALKSSIRMESDSVQQCLAGLSTKLFVCSNANNFVVSLVCENAIQTLGGIGVGLVDSTAVE 4528
LK+ + ++ V+ LA LS +L++ S N L+ ++ I+ LG I V L D+ V
Sbjct: 517 CLKAGLTIDPVIVEAFLASLSNRLYI-SQENEKDAHLIPDHTIRALGHIAVALRDTPKVM 575
Query: 4527 VPEMVVQIYLQRFANPPSQLDVTMIRCLAEMWIAGARSIYENVWKLFTQICIESSNRVYS 4348
P ++QI Q+F PPSQLDV +I L M I G + IY+ VW LF QI +++S+ VYS
Sbjct: 576 QP--ILQILQQKFCQPPSQLDVLIIDQLGCMVITGNQYIYQEVWNLFQQISVKASSVVYS 633
Query: 4347 QGNNESNDQRYTHVSLAVDVAMSRMAAGVANEDDKMTXXXXXXXXXXXLGIEGRRVGEXX 4168
+ D Y H SLAV A++ +AA + E LG+EG+R E
Sbjct: 634 -ATKDYKDHGYRHCSLAVINALANIAANIQGEHQIDDLLMNLLELFVQLGLEGKRASERA 692
Query: 4167 XXX--XXXXXXSAGNLGVLMPKIASLLRRMQPISEPTTKLRSLFRDFWFYCTVLGFDVES 3994
SAGNLGVL+P IA L RR+ PI E +L+ LFRDFW Y ++GF VE
Sbjct: 693 SEKGPALKASSSAGNLGVLIPVIAVLTRRLPPIKEAKPRLQKLFRDFWLYSVLMGFSVEG 752
Query: 3993 SSLWPEEWYNAVCETATKTPVLI--ATENLRSELIDNAAIRSDSISPQELQEMRNTVLAE 3820
S LWPEEWY VCE ATK+P+L + E LRS L N+A+++D+++P EL E+R+T+++
Sbjct: 753 SGLWPEEWYEGVCEIATKSPLLTFPSKEPLRSVLQYNSAMKNDTVTPAELNELRSTIISI 812
Query: 3819 LSHQAEAVPLINRFDFANCTYLLSVHRMETMRLIHANHVDAFSSFFKYIEDKTMRKDKSG 3640
L E LIN+ DFA TYLLSV+R+E MR++H+ D F F Y EDK ++KDKSG
Sbjct: 813 LDPAPEVSALINKLDFAMSTYLLSVYRLEHMRVLHSTDKDRFQVMFFYFEDKAIQKDKSG 872
Query: 3639 LWTCMLAAAPRIFLEWCEKMMKRRDNDEPTEEALVWHAQFLLFKFNHHLREVRKVADACL 3460
+ C++A A ++F E +M + + EE L HAQFLL FNH + +R+VAD L
Sbjct: 873 MMQCVIAVADKVF-EAFLAVMADKPKTKENEEELERHAQFLLVNFNHIHKRIRRVADKYL 931
Query: 3459 SQLVKAFPYLLWNTKVLTTILRLLQELEDNLQKDPTCREPQFTIEGFGGWTIQLQDSIEG 3280
S LV FP+LLW+ VL T+L +LQ L +L D +P + I + I + D+ E
Sbjct: 932 SGLVDKFPHLLWSGTVLKTMLDILQTLSLSLSADIHKDQPYYDIPD-APYRITVPDTYEA 990
Query: 3279 RRSVVKDFSMRVKQILKEALRWAPASTHSNLLEYVSKF-----GSERDAAMQLAIDA--- 3124
R S+VKDF+ R IL+EA++WAP+ T S+L EY++K G + + +A ++
Sbjct: 991 RESIVKDFAARCGMILQEAMKWAPSVTKSHLQEYLNKHQNWMSGLSQHTGLAMATESILH 1050
Query: 3123 --------TSEGSGKS------------------GSYLTSLYKRSNYLGQVKGMLATTLS 3022
T+ GS S +++ SL R+ Y G+V GM+
Sbjct: 1051 FAGYNRQNTTLGSPASSAQVTQLTERPACVKKDYSNFMASLNLRNRYAGEVAGMI----- 1105
Query: 3021 GDIDQVTAENQLIDRLE-KDFQRACKSGKDMEMEQAVLLLTALFVSLRSLNERILSLLVR 2845
+ T ++RL K A G+ Q + LTAL +S + + ++L L
Sbjct: 1106 -EFSDATGRTSDLNRLMLKRLSDALDCGQPEAYTQVMFKLTALLISSKECDTQLLHHLCW 1164
Query: 2844 TPLLNFTESTVSLCTMAWNWLLSARPEAHSLFLHEQARAFADSSRFGLGLFEKEVVGGSP 2665
PL FT+ + W+WLL+A+ F+ E A ++ + +GLF E P
Sbjct: 1165 APLRMFTDHGMETAIACWDWLLAAKNGIEVPFMREMAGSWQMTVEQKIGLFSAEEKEADP 1224
Query: 2664 LC---QKLERP-PPSANFRPHREWIEFIGERCDVASYSSREQLDVLEMMFSQTLSAHIGT 2497
L Q RP PP N PH WI+FI +R ++A Y S +Q+++ + ++LS +IG
Sbjct: 1225 LAASEQSQPRPCPPQVN--PHYIWIDFIMQRFEIAKYCSSDQVEIFSSLLQRSLSLNIG- 1281
Query: 2496 GHLHGSTACSNPASLAGPSRKETINQVTRGIEAVGVRFRLLSCVLGMVQQDACLLRPTNV 2317
C + R + A+G RF+LL+ L ++ D
Sbjct: 1282 -------GCK--------------GSLNRHVAAIGPRFKLLTLGLSLLHADVVPNATIRN 1320
Query: 2316 LIRQRVYSCAFHYFTIAPQGPTQPEERLREDIRLLTRFFEHLKNDKHYMQKEALAKTDKN 2137
+ R+++YS AF YF+ P+ PTQ +++LREDI ++ +F+ + +DK Y+ L D
Sbjct: 1321 VFREKIYSTAFDYFSCPPKFPTQTQKQLREDISIMIKFWTAMFSDKKYLTANQLVPPDNQ 1380
Query: 2136 LVMSSTMSQMQTNFEKSLLISXXXXXXXXXXXXXTSLMLPPSTNYANTLTLSSQKSMAAT 1957
+++S M +L ++ + + NT LSS S +
Sbjct: 1381 DPSVNSLSVMSDVNRSNLDVTVGSRQQT-------------AQGWINTYPLSSGMSTISK 1427
Query: 1956 SASIRSGKSIETKLSIEEDRRIKTWMKQRNMLMLLVANEIERLSAWLHPLALAQEDCALD 1777
+ + + T+L K +MK+R +L+ L+A EIERL W +P L+ + LD
Sbjct: 1428 KSGLTKKTNRGTQLH-------KYYMKRRTLLLSLLATEIERLITWYNP--LSSPELELD 1478
Query: 1776 SEEFLRGAFTQAKATGGEKNIWREQAQLAWDISPELAIQLPSRFRGSPELVKYVDVLVRG 1597
A ++K + W++ LAW ISP LA+QLP+RF+ + + V LVR
Sbjct: 1479 QTGENSVANWRSKYISLSEKQWKDNVNLAWSISPHLALQLPNRFKNTEAIGGEVTRLVRL 1538
Query: 1596 QPEPVAHIPEALPLFLGNGSTVFETSDMSHVLTWARCSPVMALSLLTPRIYPMHPISMQY 1417
P V+ PEA+ + + + ++SH+L WA P LS + +YP HP++ QY
Sbjct: 1539 DPGAVSDTPEAIKYLVTWHTIDADAPELSHILCWAPTDPPTGLSYFS-SLYPPHPLTAQY 1597
Query: 1416 AVRVLRSYSADELLLYIPQIVQAVRYDTMGYISELIIWLAGHSQLLSHQLIWNMQTNMFT 1237
V+VLRS+ D +L YIPQIVQA+RYD MGY+ E I+W A SQLL+HQ IWNM+TN+F
Sbjct: 1598 GVKVLRSFPPDAILFYIPQIVQALRYDKMGYVREYILWAAAKSQLLAHQFIWNMKTNIFL 1657
Query: 1236 DEESKVKDPVLFEALNDIMQKILSQLEGAARRFHEAEFKLFHQLTAISGTIKPFPKGDAR 1057
DEE KDP + E L ++++I L G A+ F++ EF F+++T +S IKPFPKG+ R
Sbjct: 1658 DEEGHQKDPDIGELLEQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPFPKGEER 1717
Query: 1056 KKACLKALADVKIETITYLPSNPEAVLLDLDYSSGTPMQSAAKAPFLARFRVKRCGVREL 877
KKACL +LA+VK++ YLPSNPEA++LD+DY+SGTP+QSAAKAP+LA+F+VKRCGV EL
Sbjct: 1718 KKACLNSLAEVKVQPGCYLPSNPEAIVLDIDYTSGTPLQSAAKAPYLAKFKVKRCGVSEL 1777
Query: 876 EHIGLQAQSEHGGKTTEADLEELKKVQDSRVCWQAAIFKVGDDVRXXXXXXXXXXXMKNV 697
E GL +S+ ++ E + D +VCWQAAIFKVGDD R KN+
Sbjct: 1778 EKEGLSCRSDSIDESEE-------EGGDGKVCWQAAIFKVGDDCRQDMLALQIIGLFKNI 1830
Query: 696 WAGLGLPVRVFPYRVVATSPGCGVIECVPNSKSRDQLGRQTDFGLYEYFKTQYGDESSET 517
+ +GL + VFPYRVVAT+PGCGVIEC+P+ SRDQLGRQTDFG+Y+YF QYGDES+
Sbjct: 1831 FQLVGLDLFVFPYRVVATAPGCGVIECIPDCSSRDQLGRQTDFGMYDYFTRQYGDESALA 1890
Query: 516 FQEARRNFVRSMAAYSVFSFLLQIKDRHNGNIMIDLDGHIIHIDFGFMFESSPGGNLGFE 337
FQ+AR NF+RSMAAYS+ FLLQIKDRHNGNIM+D GHIIHIDFGFMFESSPGGNLG+E
Sbjct: 1891 FQKARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFMFESSPGGNLGWE 1950
Query: 336 PDFKLSEEMVAIMGGKMEAAPFRQFASLCVHAYLAVRPYHKSFVSLVSLMLDTHLPCFRG 157
PD KL++EMV IMGGKMEA PF+ F +CV YLAVRPY + VSLV+LMLDT LPCFRG
Sbjct: 1951 PDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFRG 2010
Query: 156 KTINQLRARFAPEMNEKDAAKYMYSVITNCFLNIRSKMYDQLQYFQNEIPY 4
+TI L+ RF+P E++AA ++ VI NCFL+ RS+ YD +QY+QN+IPY
Sbjct: 2011 QTIKLLKQRFSPNSTEREAANFILKVIQNCFLSNRSRTYDMIQYYQNDIPY 2061
>gi|25742825|ref|NP_071637.1| phosphatidylinositol 4-kinase a [Rattus
norvegicus]
gi|1944499|dbj|BAA19614.1| 230kDa phosphatidylinositol 4-kinase
[Rattus norvegicus]
Length = 2041
Score = 1259 bits (3257), Expect = 0.0
Identities = 790/2148 (36%), Positives = 1160/2148 (53%), Gaps = 89/2148 (4%)
Frame = -1
Query: 6180 LSHNVRCSLIAIANYLLHSHGQHADELVPMLLRALIALPHMKWIDDGLLNKS-DKIPIQE 6004
L R ++IA+ +L+ S QH D +VP LLR L LP + W+++ K +P+ E
Sbjct: 12 LDERRRDAVIALGIFLIESDLQHKDCIVPYLLRLLRGLPKVYWVEESTARKGRGNLPVAE 71
Query: 6003 QFSFCFNTSLSDLAAHLPRFRQQIVSAQADALACAVSSIYDVLEDQESLEHNYSHVIKLM 5824
FSFC T LSD+A P R +I+ A L + + LE QE E+ + I +
Sbjct: 72 SFSFCLVTLLSDVACRDPSLRDEILEALLQVLHVLLG-MCQALEIQEK-EYLCKYAIPCL 129
Query: 5823 CYALGLLRSIGRFSADYDTPLISLIFP---------------------------LPVDET 5725
+G+ +S GR+S ++ L+S +FP LP +
Sbjct: 130 ---IGISKSFGRYSNSEES-LLSKLFPKVPPHSLRIPEELEGVRRRSFNDFRSILPSNLL 185
Query: 5724 KKCKGAGGADIKHRISSDEFTFDTSCDASSSDPL-------------LLTDSKSSRLIRM 5584
C+ +K + SS S + P L D +
Sbjct: 186 TVCQEG---TLKRKTSSVSSISQVSPERGMPPPSSPGGSAFHYFEASCLPDGTTLEPEYY 242
Query: 5583 YNKLGASFLLNNYTGGL---KLTMSSEDLEKLFDSVQRLMDSKFLESLDXXXXXXXXXXX 5413
++ + +SF ++ G+ + + E L +L + V+++++ L+SLD
Sbjct: 243 FSTISSSFSVSPLFNGITYKEFYIPLEMLRELLNLVKKIVEEPVLKSLDAAVARV----- 297
Query: 5412 GVKRNP-----YKSMSEITNLCCLTLLKDVLGPYSVKNSDKNQENCGNSLQEASPSSPIS 5248
++ NP Y + S+ L +L+D L Y +K+ P+S +
Sbjct: 298 -MEANPSADLYYTTFSDPVYLTMFKMLRDTL--YYMKDL---------------PTSFVK 339
Query: 5247 E--KFAKEISIFSKTALSKLDAXXXXXXXXXXXXXXXXXSRQKLNIQSATVCLQLXXXXX 5074
E F E S+ L K+ S KL Q+ C+ L
Sbjct: 340 EIHDFVLEQFNMSQGELQKI--------LHDADRIHSEMSPLKLRCQANAACVDLMVWAV 391
Query: 5073 XXXXXXXXICTEIIVRLFANQTQKTIISQLPLYLKAISSMATLAEKFPAVATTAVIQNLQ 4894
+C ++ +L + + K II+ LPL + + + L E+FP V + V +L+
Sbjct: 392 KDEQGAENLCIKLSEKLQSKTSSKVIIAHLPLLICCLQGLGRLCERFPVVVHS-VTPSLR 450
Query: 4893 RFLLEPAPMLTKLASDSTLERGKSAGDVI-----QHSKSSNNLIDAITKRKLSLDALRNS 4729
FL+ P+P+L KL + + D+ +HS+S+ N++ + + LR+
Sbjct: 451 DFLVIPSPVLVKLYKYHSQYHTVAGSDIKISVTNEHSESTLNVLPGKKNQPSMYEQLRDI 510
Query: 4728 AIKAICRALKSSIRMESDSVQQCLAGLSTKLFVCSNANNFVVSLVCENAIQTLGGIGVGL 4549
AI ICR LK+ + ++ V+ LA LS +L++ S ++ L+ ++ I+ LG I V L
Sbjct: 511 AIDNICRCLKAGLTVDPVIVEAFLASLSNRLYI-SQESDKDAHLIPDHTIRALGHIAVAL 569
Query: 4548 VDSTAVEVPEMVVQIYLQRFANPPSQLDVTMIRCLAEMWIAGARSIYENVWKLFTQICIE 4369
D+ P+++ I Q+F PPS LDV +I L + I G + IY+ VW LF QI ++
Sbjct: 570 RDT-----PKVMEPILQQKFCQPPSPLDVLIIDQLGCLVITGNQYIYQEVWNLFQQISVK 624
Query: 4368 SSNRVYSQGNNESNDQRYTHVSLAVDVAMSRMAAGVANEDDKMTXXXXXXXXXXXLGIEG 4189
+S+ VYS + D Y H SLAV A++ +AA + E LG+EG
Sbjct: 625 ASSVVYS-ATKDYKDHGYRHCSLAVINALANIAANIQEEHLVDELLMNLLELFVQLGLEG 683
Query: 4188 RRVGEXXXXX--XXXXXXSAGNLGVLMPKIASLLRRMQPISEPTTKLRSLFRDFWFYCTV 4015
+R E SAGNLGVL+P IA L RR+ PI E +L+ LFRDFW Y +
Sbjct: 684 KRASERASEKGPALKASSSAGNLGVLIPVIAVLTRRLPPIKEAKPRLQKLFRDFWLYSVL 743
Query: 4014 LGFDVESSSLWPEEWYNAVCETATKTPVLI--ATENLRSELIDNAAIRSDSISPQELQEM 3841
+GF VE S LWPEEWY VCE ATK+P+L + E LRS L N+A+++D+++P EL E+
Sbjct: 744 MGFAVEGSGLWPEEWYEGVCEIATKSPLLTFPSKEPLRSVLQYNSAMKNDTVTPAELNEL 803
Query: 3840 RNTVLAELSHQAEAVPLINRFDFANCTYLLSVHRMETMRLIHANHVDAFSSFFKYIEDKT 3661
R+T++ L E LIN+ DFA TYLLSV+R+E MR++ + D F F Y EDK
Sbjct: 804 RSTIINLLDPPPEVSALINKLDFAMSTYLLSVYRLEYMRVLRSTDPDRFQVMFCYFEDKA 863
Query: 3660 MRKDKSGLWTCMLAAAPRIFLEWCEKMMKRRDNDEPTEEALVWHAQFLLFKFNHHLREVR 3481
++KDKSG+ C++A A ++F + M ++ E EE L HAQFLL FNH + +R
Sbjct: 864 IQKDKSGMMQCVIAVADKVFDAFLNMMAEKAKTKE-NEEELERHAQFLLVNFNHIHKRIR 922
Query: 3480 KVADACLSQLVKAFPYLLWNTKVLTTILRLLQELEDNLQKDPTCREPQFTIEGFGGWTIQ 3301
+VAD LS LV FP+LLW+ VL T+L +LQ L +L D +P + I + I
Sbjct: 923 RVADKYLSGLVDKFPHLLWSGTVLKTMLDILQTLSLSLSADIHKDQPYYDIPD-APYRIT 981
Query: 3300 LQDSIEGRRSVVKDFSMRVKQILKEALRWAPASTHSNLLEYVSKF-----GSERDAAMQL 3136
+ D+ E R S+VKDF+ R IL+EA++WAP T S+L EY++K G + + +
Sbjct: 982 VPDTYEARESIVKDFAARCGMILQEAMKWAPTVTKSHLQEYLNKHQNWVSGLSQHTGLAM 1041
Query: 3135 AIDATSEGSGKS----------------------GSYLTSLYKRSNYLGQVKGMLATTLS 3022
A ++ +G + +++ SL R+ Y G+V GM+ S
Sbjct: 1042 ATESILHFAGYNKQNTTLGVTQLTERPACVKKDYSNFMASLNLRNRYAGEVHGMIR--FS 1099
Query: 3021 GDIDQVTAENQLIDRLEKDFQRACKSGKDMEMEQAVLLLTALFVSLRSLNERILSLLVRT 2842
G Q++ N++ + +D A QA+ LTA+ +S + + ++L L
Sbjct: 1100 GATGQMSDLNKM---MVQDLITALDHSHPQHYTQAMFKLTAMLISSKDCDPQLLHHLCWG 1156
Query: 2841 PLLNFTESTVSLCTMAWNWLLSARPEAHSLFLHEQARAFADSSRFGLGLFEKEVVGGSPL 2662
PL F E + W WLL+ + F+ E A A+ + GLF E PL
Sbjct: 1157 PLRMFNEHGMETALACWEWLLAGKNGVEVPFMREMAGAWHMTVEQKFGLFSAETKEADPL 1216
Query: 2661 C-QKLERPPPSA-NFRPHREWIEFIGERCDVASYSSREQLDVLEMMFSQTLSAHIGTGHL 2488
+ +P P PH WI+F+ +R ++A Y S +Q+++ + +++S HIG
Sbjct: 1217 AASEASQPRPCPPEVTPHYIWIDFLVQRFEIAKYCSSDQVEIFSSLLQRSMSLHIGGAR- 1275
Query: 2487 HGSTACSNPASLAGPSRKETINQVTRGIEAVGVRFRLLSCVLGMVQQDACLLRPTNVLIR 2308
+ R + A+G RF+LL+ L ++ D ++R
Sbjct: 1276 ---------------------GSMNRHVAAIGPRFKLLTLGLSLLHADVVPNATIRNVLR 1314
Query: 2307 QRVYSCAFHYFTIAPQGPTQPEERLREDIRLLTRFFEHLKNDKHYMQKEALAKTDKNLVM 2128
+++YS AF YF+ P+ PTQ E+RLREDI ++ +F+ + +DK Y+ L D
Sbjct: 1315 EKIYSTAFDYFSCPPKFPTQGEKRLREDISIMIKFWTAMFSDKKYLTASQLVPPDNQDTR 1374
Query: 2127 SSTMSQMQTNFEKSLLISXXXXXXXXXXXXXTSLMLPPSTNYANTLTLSSQKSMAATSAS 1948
S+ + + + + + NT LSS S + S
Sbjct: 1375 SNLDITVGSRQQAT-------------------------QGWINTYPLSSGMS----TIS 1405
Query: 1947 IRSGKSIETKLSIEEDRRIKTWMKQRNMLMLLVANEIERLSAWLHPLALAQEDCALDSEE 1768
+SG S +T + K +MK+R +L+ L+A EIERL W +PL+ + + E
Sbjct: 1406 KKSGMSKKTNRGSQLH---KYYMKRRTLLLSLLATEIERLITWYNPLSAPELELDQAGEN 1462
Query: 1767 FLRGAFTQAKATGGEKNIWREQAQLAWDISPELAIQLPSRFRGSPELVKYVDVLVRGQPE 1588
+ A ++K + W++ LAW ISP LA+QLP+RF+ + + V LVR P
Sbjct: 1463 SV--ANWRSKYISLSEKQWKDNVNLAWTISPYLAVQLPARFKNTEAIGNEVTRLVRLDPG 1520
Query: 1587 PVAHIPEALPLFLGNGSTVFETSDMSHVLTWARCSPVMALSLLTPRIYPMHPISMQYAVR 1408
V+ +PEA+ + + + ++SHVL WA P LS + +YP HP++ QY V+
Sbjct: 1521 AVSDVPEAIKFLVTWHTIDADAPELSHVLCWAPTDPPTGLSYFSS-MYPPHPLTAQYGVK 1579
Query: 1407 VLRSYSADELLLYIPQIVQAVRYDTMGYISELIIWLAGHSQLLSHQLIWNMQTNMFTDEE 1228
VLRS+ D +L YIPQIVQA+RYD MGY+ E I+W A SQLL+HQ IWNM+TN++ DEE
Sbjct: 1580 VLRSFPPDAILFYIPQIVQALRYDKMGYVREYILWAAAKSQLLAHQFIWNMKTNIYLDEE 1639
Query: 1227 SKVKDPVLFEALNDIMQKILSQLEGAARRFHEAEFKLFHQLTAISGTIKPFPKGDARKKA 1048
KDP + + L ++++I L G A+ F++ EF F+++T +S IKP+PKGD RKKA
Sbjct: 1640 GHQKDPDIGDLLEQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPYPKGDERKKA 1699
Query: 1047 CLKALADVKIETITYLPSNPEAVLLDLDYSSGTPMQSAAKAPFLARFRVKRCGVRELEHI 868
CL AL++VK++ YLPSNPEA++LD+DY SGTPMQSAAKAP+LA+F+VKRCGV ELE
Sbjct: 1700 CLSALSEVKVQPGCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKE 1759
Query: 867 GLQAQSEHGGKTTEADLEELKKVQDSRVCWQAAIFKVGDDVRXXXXXXXXXXXMKNVWAG 688
GLQ +S+ TE + ++ ++CWQAAIFKVGDD R KN++
Sbjct: 1760 GLQCRSD-----TEDECRR-QEADGKKICWQAAIFKVGDDCRQDMLALQIIDLFKNIFQL 1813
Query: 687 LGLPVRVFPYRVVATSPGCGVIECVPNSKSRDQLGRQTDFGLYEYFKTQYGDESSETFQE 508
+GL + VFPYRVVAT+PGCGVIEC+P+ SRDQLGRQTDFG+Y+YF QYGDES+ FQ+
Sbjct: 1814 VGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQLGRQTDFGMYDYFTRQYGDESTLAFQQ 1873
Query: 507 ARRNFVRSMAAYSVFSFLLQIKDRHNGNIMIDLDGHIIHIDFGFMFESSPGGNLGFEPDF 328
AR NF+RSMAAYS+ FLLQIKDRHNGNIM+D GHIIHIDFGFMFESSPGGNLG+EPD
Sbjct: 1874 ARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFMFESSPGGNLGWEPDI 1933
Query: 327 KLSEEMVAIMGGKMEAAPFRQFASLCVHAYLAVRPYHKSFVSLVSLMLDTHLPCFRGKTI 148
KL++EMV IMGGKMEA PF+ F +CV YLAVRPY + VSLV+LMLDT LPCFRG+TI
Sbjct: 1934 KLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFRGQTI 1993
Query: 147 NQLRARFAPEMNEKDAAKYMYSVITNCFLNIRSKMYDQLQYFQNEIPY 4
L+ RF+P M E++AA ++ +I NCFL+ RS+ YD +QY+QN+IPY
Sbjct: 1994 KLLKHRFSPNMTEREAANFIMKIIQNCFLSNRSRTYDMIQYYQNDIPY 2041
>gi|17105400|ref|NP_477352.1| phosphatidylinositol 4-kinase,
catalytic, alpha polypeptide isoform 2;
phosphatidylinositol 4-kinase, type II, alpha;
phosphatidylinositol 4-kinase, type III, alpha;
phosphatidylinositol 4-kinase 230 [Homo sapiens]
gi|38258919|sp|P42356|PI4K_HUMAN Phosphatidylinositol 4-kinase alpha
(PI4-kinase) (PtdIns-4-kinase) (PI4K-alpha)
gi|2326227|gb|AAD13352.1| phosphatidylinositol 4-kinase 230 [Homo
sapiens]
Length = 2044
Score = 1255 bits (3247), Expect = 0.0
Identities = 793/2147 (36%), Positives = 1171/2147 (53%), Gaps = 88/2147 (4%)
Frame = -1
Query: 6180 LSHNVRCSLIAIANYLLHSHGQHADELVPMLLRALIALPHMKWIDDGLLNKS-DKIPIQE 6004
L R ++IA+ +L+ S QH D +VP LLR L LP + W+++ K +P+ E
Sbjct: 12 LDERRRDAVIALGIFLIESDLQHKDCVVPYLLRLLKGLPKVYWVEESTARKGRGALPVAE 71
Query: 6003 QFSFCFNTSLSDLAAHLPRFRQQIVSAQADALACAVSSIYDVLEDQESLEHNYSHVIKLM 5824
FSFC T LSD+A P R +I+ L + + LE Q+ E+ + I +
Sbjct: 72 SFSFCLVTLLSDVAYRDPSLRDEILEVLLQVLHVLLG-MCQALEIQDK-EYLCKYAIPCL 129
Query: 5823 CYALGLLRSIGRFSADYDTPLISLIFP-LP------VDETKKCKGAGGADIKHRISSDEF 5665
+G+ R+ GR+S + + L+S +FP +P ++E + + D + + S+
Sbjct: 130 ---IGISRAFGRYS-NMEESLLSKLFPKIPPHSLRVLEELEGVRRRSFNDFRSILPSNLL 185
Query: 5664 TF--------DTSCDASSS----------------------DPLLLTDSKSSRLIRMYNK 5575
T TS +S S + L D + ++
Sbjct: 186 TVCQEGTLKRKTSSVSSISQVSPERGMPPPSSPGGSAFHYFEASCLPDGTALEPEYYFST 245
Query: 5574 LGASFLLNNYTGGL---KLTMSSEDLEKLFDSVQRLMDSKFLESLDXXXXXXXXXXXGVK 5404
+ +SF ++ G+ + + E L +L + V+++++ L+SLD ++
Sbjct: 246 ISSSFSVSPLFNGVTYKEFNIPLEMLRELLNLVKKIVEEAVLKSLDAIVASV------ME 299
Query: 5403 RNP-----YKSMSEITNLCCLTLLKDVLGPYSVKNSDKNQENCGNSLQEASPSSPISE-- 5245
NP Y S S+ L +L+D L Y +K+ P+S + E
Sbjct: 300 ANPSADLYYTSFSDPLYLTMFKMLRDTL--YYMKDL---------------PTSFVKEIH 342
Query: 5244 KFAKEISIFSKTALSKLDAXXXXXXXXXXXXXXXXXSRQKLNIQSATVCLQLXXXXXXXX 5065
F E S+ L K+ S KL Q++ C+ L
Sbjct: 343 DFVLEQFNTSQGELQKI--------LHDADRIHNELSPLKLRCQASAACVDLMVWAVKDE 394
Query: 5064 XXXXXICTEIIVRLFANQTQKTIISQLPLYLKAISSMATLAEKFPAVATTAVIQNLQRFL 4885
+C ++ +L + + K II+ LPL + + + L E+FP V + V +L+ FL
Sbjct: 395 QGAENLCIKLSEKLQSKTSSKVIIAHLPLLICCLQGLGRLCERFPVVVHS-VTPSLRDFL 453
Query: 4884 LEPAPMLTKLASDSTLERGKSAGDVI-----QHSKSSNNLIDAITKRKLSLDALRNSAIK 4720
+ P+P+L KL + + D+ +HS+S+ N++ + + LR+ AI
Sbjct: 454 VIPSPVLVKLYKYHSQYHTVAGNDIKISVTNEHSESTLNVMSGKKSQPSMYEQLRDIAID 513
Query: 4719 AICRALKSSIRMESDSVQQCLAGLSTKLFVCSNANNFVVSLVCENAIQTLGGIGVGLVDS 4540
ICR LK+ + ++ V+ LA LS +L++ S ++ L+ ++ I+ LG I V L D+
Sbjct: 514 NICRCLKAGLTVDPVIVEAFLASLSNRLYI-SQESDKDAHLIPDHTIRALGHIAVALRDT 572
Query: 4539 TAVEVPEMVVQIYLQRFANPPSQLDVTMIRCLAEMWIAGARSIYENVWKLFTQICIESSN 4360
V P ++QI Q+F PPS LDV +I L + I G + IY+ VW LF QI +++S+
Sbjct: 573 PKVMEP--ILQILQQKFCQPPSPLDVLIIDQLGCLVITGNQYIYQEVWNLFQQISVKASS 630
Query: 4359 RVYSQGNNESNDQRYTHVSLAVDVAMSRMAAGVANEDDKMTXXXXXXXXXXXLGIEGRRV 4180
VYS + D Y H SLAV A++ +AA + +E LG+EG+R
Sbjct: 631 VVYS-ATKDYKDHGYRHCSLAVINALANIAANIQDEHLVDELLMNLLELFVQLGLEGKRA 689
Query: 4179 GEXXXXX--XXXXXXSAGNLGVLMPKIASLLRRMQPISEPTTKLRSLFRDFWFYCTVLGF 4006
E SAGNLGVL+P IA L RR+ PI E +L+ LFRDFW Y ++GF
Sbjct: 690 SERASEKGPALKASSSAGNLGVLIPVIAVLTRRLPPIKEAKPRLQKLFRDFWLYSVLMGF 749
Query: 4005 DVESSSLWPEEWYNAVCETATKTPVLI--ATENLRSELIDNAAIRSDSISPQELQEMRNT 3832
VE S LWPEEWY VCE ATK+P+L + E LRS L N+A+++D+++P EL E+R+T
Sbjct: 750 AVEGSGLWPEEWYEGVCEIATKSPLLTFPSKEPLRSVLQYNSAMKNDTVTPAELSELRST 809
Query: 3831 VLAELSHQAEAVPLINRFDFANCTYLLSVHRMETMRLIHANHVDAFSSFFKYIEDKTMRK 3652
++ L E LIN+ DFA TYLLSV+R+E MR++ + D F F Y EDK ++K
Sbjct: 810 IINLLDPPPEVSALINKLDFAMSTYLLSVYRLEYMRVLRSTDPDRFQVMFCYFEDKAIQK 869
Query: 3651 DKSGLWTCMLAAAPRIFLEWCEKMMKRRDNDEPTEEALVWHAQFLLFKFNHHLREVRKVA 3472
DKSG+ C++A A ++F + M + E EE L HAQFLL FNH + +R+VA
Sbjct: 870 DKSGMMQCVIAVADKVFDAFLNMMADKAKTKE-NEEELERHAQFLLVNFNHIHKRIRRVA 928
Query: 3471 DACLSQLVKAFPYLLWNTKVLTTILRLLQELEDNLQKDPTCREPQFTIEGFGGWTIQLQD 3292
D LS LV FP+LLW+ VL T+L +LQ L +L D +P + I + I + D
Sbjct: 929 DKYLSGLVDKFPHLLWSGTVLKTMLDILQTLSLSLSADIHKDQPYYDIPD-APYRITVPD 987
Query: 3291 SIEGRRSVVKDFSMRVKQILKEALRWAPASTHSNLLEYVSKF-----GSERDAAMQLAID 3127
+ E R S+VKDF+ R IL+EA++WAP T S+L EY++K G + + +A +
Sbjct: 988 TYEARESIVKDFAARCGMILQEAMKWAPTVTKSHLQEYLNKHQNWVSGLSQHTGLAMATE 1047
Query: 3126 ATSEGSGKS----------------------GSYLTSLYKRSNYLGQVKGMLATTLSGDI 3013
+ +G + +++ SL R+ Y G+V GM+ SG
Sbjct: 1048 SILHFAGYNKQNTTLGATQLSERPACVKKDYSNFMASLNLRNRYAGEVYGMIR--FSGTT 1105
Query: 3012 DQVTAENQLIDRLEKDFQRACKSGKDMEMEQAVLLLTALFVSLRSLNERILSLLVRTPLL 2833
Q++ N++ + +D A QA+ LTA+ +S + + ++L L PL
Sbjct: 1106 GQMSDLNKM---MVQDLHSALDRSHPQHYTQAMFKLTAMLISSKDCDPQLLHHLCWGPLR 1162
Query: 2832 NFTESTVSLCTMAWNWLLSARPEAHSLFLHEQARAFADSSRFGLGLFEKEVVGGSPLC-Q 2656
F E + W WLL+ + F+ E A A+ + GLF E+ PL
Sbjct: 1163 MFNEHGMETALACWEWLLAGKDGVEVPFMREMAGAWHMTVEQKFGLFSAEIKEADPLAAS 1222
Query: 2655 KLERPPPSA-NFRPHREWIEFIGERCDVASYSSREQLDVLEMMFSQTLSAHIGTGHLHGS 2479
+ +P P PH WI+F+ +R ++A Y S +Q+++ + +++S +IG
Sbjct: 1223 EASQPKPCPPEVTPHYIWIDFLVQRFEIAKYCSSDQVEIFSSLLQRSMSLNIG------- 1275
Query: 2478 TACSNPASLAGPSRKETINQVTRGIEAVGVRFRLLSCVLGMVQQDACLLRPTNVLIRQRV 2299
K ++N R + A+G RF+LL+ L ++ D ++R+++
Sbjct: 1276 ------------GAKGSMN---RHVAAIGPRFKLLTLGLSLLHADVVPNATIRNVLREKI 1320
Query: 2298 YSCAFHYFTIAPQGPTQPEERLREDIRLLTRFFEHLKNDKHYMQKEALAKTDKNLVMSST 2119
YS AF YF+ P+ PTQ E+RLREDI ++ +F+ + +DK Y+ L D S+
Sbjct: 1321 YSTAFDYFSCPPKFPTQGEKRLREDISIMIKFWTAMFSDKKYLTASQLVPPDNQDTRSNL 1380
Query: 2118 MSQMQTNFEKSLLISXXXXXXXXXXXXXTSLMLPPSTNYANTLTLSSQKSMAATSASIRS 1939
+ + + + + NT LSS S + S +S
Sbjct: 1381 DITVGSRQQAT-------------------------QGWINTYPLSSGMS----TISKKS 1411
Query: 1938 GKSIETKLSIEEDRRIKTWMKQRNMLMLLVANEIERLSAWLHPLALAQEDCALDSEEFLR 1759
G S +T + K +MK+R +L+ L+A EIERL W +PL+ + + E +
Sbjct: 1412 GMSKKTNRGSQLH---KYYMKRRTLLLSLLATEIERLITWYNPLSAPELELDQAGENSV- 1467
Query: 1758 GAFTQAKATGGEKNIWREQAQLAWDISPELAIQLPSRFRGSPELVKYVDVLVRGQPEPVA 1579
A ++K + W++ LAW ISP LA+QLP+RF+ + + V LVR P V+
Sbjct: 1468 -ANWRSKYISLSEKQWKDNVNLAWSISPYLAVQLPARFKNTEAIGNEVTRLVRLDPGAVS 1526
Query: 1578 HIPEALPLFLGNGSTVFETSDMSHVLTWARCSPVMALSLLTPRIYPMHPISMQYAVRVLR 1399
+PEA+ + + + ++SHVL WA P LS + +YP HP++ QY V+VLR
Sbjct: 1527 DVPEAIKFLVTWHTIDADAPELSHVLCWAPTDPPTGLSYFSS-MYPPHPLTAQYGVKVLR 1585
Query: 1398 SYSADELLLYIPQIVQAVRYDTMGYISELIIWLAGHSQLLSHQLIWNMQTNMFTDEESKV 1219
S+ D +L YIPQIVQA+RYD MGY+ E I+W A SQLL+HQ IWNM+TN++ DEE
Sbjct: 1586 SFPPDAILFYIPQIVQALRYDKMGYVREYILWAASKSQLLAHQFIWNMKTNIYLDEEGHQ 1645
Query: 1218 KDPVLFEALNDIMQKILSQLEGAARRFHEAEFKLFHQLTAISGTIKPFPKGDARKKACLK 1039
KDP + + L+ ++++I L G A+ F++ EF F+++T +S IKP+PKGD RKKACL
Sbjct: 1646 KDPDIGDLLDQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPYPKGDERKKACLS 1705
Query: 1038 ALADVKIETITYLPSNPEAVLLDLDYSSGTPMQSAAKAPFLARFRVKRCGVRELEHIGLQ 859
AL++VK++ YLPSNPEA++LD+DY SGTPMQSAAKAP+LA+F+VKRCGV ELE GL+
Sbjct: 1706 ALSEVKVQPGCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEGLR 1765
Query: 858 AQSEHGGK--TTEADLEELKKVQDSRVCWQAAIFKVGDDVRXXXXXXXXXXXMKNVWAGL 685
+S+ + T EAD ++ WQAAIFKVGDD R KN++ +
Sbjct: 1766 CRSDSEDECSTQEAD--------GQKISWQAAIFKVGDDCRQDMLALQIIDLFKNIFQLV 1817
Query: 684 GLPVRVFPYRVVATSPGCGVIECVPNSKSRDQLGRQTDFGLYEYFKTQYGDESSETFQEA 505
GL + VFPYRVVAT+PGCGVIEC+P+ SRDQLGRQTDFG+Y+YF QYGDES+ FQ+A
Sbjct: 1818 GLDLFVFPYRVVATAPGCGVIECIPDCTSRDQLGRQTDFGMYDYFTRQYGDESTLAFQQA 1877
Query: 504 RRNFVRSMAAYSVFSFLLQIKDRHNGNIMIDLDGHIIHIDFGFMFESSPGGNLGFEPDFK 325
R NF+RSMAAYS+ FLLQIKDRHNGNIM+D GHIIHIDFGFMFESSPGGNLG+EPD K
Sbjct: 1878 RYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFMFESSPGGNLGWEPDIK 1937
Query: 324 LSEEMVAIMGGKMEAAPFRQFASLCVHAYLAVRPYHKSFVSLVSLMLDTHLPCFRGKTIN 145
L++EMV IMGGKMEA PF+ F +CV YLAVRPY + VSLV+LMLDT LPCFRG+TI
Sbjct: 1938 LTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFRGQTIK 1997
Query: 144 QLRARFAPEMNEKDAAKYMYSVITNCFLNIRSKMYDQLQYFQNEIPY 4
L+ RF+P M E++AA ++ VI +CFL+ RS+ YD +QY+QN+IPY
Sbjct: 1998 LLKHRFSPNMTEREAANFIMKVIQSCFLSNRSRTYDMIQYYQNDIPY 2044
>gi|50233838|ref|NP_001001983.1| phosphatidylinositol 4-kinase,
catalytic, alpha polypeptide [Mus musculus]
gi|49523336|gb|AAH75629.1| Phosphatidylinositol 4-kinase, catalytic,
alpha polypeptide [Mus musculus]
Length = 2044
Score = 1255 bits (3247), Expect = 0.0
Identities = 793/2150 (36%), Positives = 1160/2150 (53%), Gaps = 91/2150 (4%)
Frame = -1
Query: 6180 LSHNVRCSLIAIANYLLHSHGQHADELVPMLLRALIALPHMKWIDDGLLNKS-DKIPIQE 6004
L R ++IA+ +L+ S QH D +VP LLR L LP + W+++ K +P+ E
Sbjct: 12 LDERRRDAVIALGIFLIESDLQHKDCVVPYLLRLLRGLPKVYWVEESTARKGRGNLPVAE 71
Query: 6003 QFSFCFNTSLSDLAAHLPRFRQQIVSAQADALACAVSSIYDVLEDQESLEHNYSHVIKLM 5824
FSFC T LSD+A P R +I+ A L + + LE QE E+ + I +
Sbjct: 72 SFSFCLVTLLSDVACRDPSLRDEILEAILQVLHVLLG-MCQALEIQEK-EYLCKYAIPCL 129
Query: 5823 CYALGLLRSIGRFSADYDTPLISLIFP---------------------------LPVDET 5725
+G+ RS GR+S ++ L+S +FP LP +
Sbjct: 130 ---IGISRSFGRYSNSEES-LLSKLFPKVSPHSLRIPEELEGVRRRSFNDFRSILPSNLL 185
Query: 5724 KKCKGAGGADIKHRISSDEFTFDTSCDASSSDPL-------------LLTDSKSSRLIRM 5584
C+ +K + SS S + P L D +
Sbjct: 186 TVCQEG---TLKRKTSSVSSISQVSPERGIPPPSSPGGSAFHYFEASCLPDGTALEPEYY 242
Query: 5583 YNKLGASFLLNNYTGGL---KLTMSSEDLEKLFDSVQRLMDSKFLESLDXXXXXXXXXXX 5413
++ + +SF ++ G+ + + E L +L + V+++++ L+SLD
Sbjct: 243 FSTISSSFSISPLFNGITYKEFCIPLEMLRELLNLVKKIVEEPVLKSLDAIVAGV----- 297
Query: 5412 GVKRNP-----YKSMSEITNLCCLTLLKDVLGPYSVKNSDKNQENCGNSLQEASPSSPIS 5248
++ NP Y + S+ L +L+D L Y +K+ P+S +
Sbjct: 298 -MEANPSADLYYTTFSDPLYLTMFKMLRDTL--YYMKDL---------------PTSFVK 339
Query: 5247 E--KFAKEISIFSKTALSKLDAXXXXXXXXXXXXXXXXXSRQKLNIQSATVCLQLXXXXX 5074
E F E S+ L K+ S KL Q+ C+ L
Sbjct: 340 EIHDFVLEQFNMSQGELQKI--------LHDADRIHSEMSPLKLRCQANAACVDLMVWAV 391
Query: 5073 XXXXXXXXICTEIIVRLFANQTQKTIISQLPLYLKAISSMATLAEKFPAVATTAVIQNLQ 4894
+C ++ +L + + K II+ LPL + + + L E+FP V + V +L+
Sbjct: 392 KDEQGAENLCIKLSEKLQSKTSSKVIIAHLPLLICCLQGLGRLCERFPVVVHS-VTPSLR 450
Query: 4893 RFLLEPAPMLTKLASDSTLERGKSAGDVI-----QHSKSSNNLIDAITKRKLSLDALRNS 4729
FL+ P+P+L KL + + D+ +HS+S+ N++ + + LR+
Sbjct: 451 DFLVIPSPVLVKLYKYHSQYHTVAGSDIKISVTNEHSESTLNVLPGKKNQPSMYEQLRDI 510
Query: 4728 AIKAICRALKSSIRMESDSVQQCLAGLSTKLFVCSNANNFVVSLVCENAIQTLGGIGVGL 4549
AI ICR LK+ + ++ V+ LA LS +L++ S ++ L+ ++ I+ LG I V L
Sbjct: 511 AIDNICRCLKAGLTVDPVIVEAFLASLSNRLYI-SQESDKDAHLIPDHTIRALGHIAVAL 569
Query: 4548 VDSTAVEVPEMVVQIYLQRFANPPSQLDVTMIRCLAEMWIAGARSIYENVWKLFTQICIE 4369
D+ V P ++QI Q+F PPS LDV +I L + I G + IY+ VW LF QI ++
Sbjct: 570 RDTPKVMEP--ILQILQQKFCQPPSPLDVLIIDQLGCLVITGNQYIYQEVWNLFQQISVK 627
Query: 4368 SSNRVYSQGNNESNDQRYTHVSLAVDVAMSRMAAGVANEDDKMTXXXXXXXXXXXLGIEG 4189
+S+ VYS + D Y H SLAV A++ +AA + E LG+EG
Sbjct: 628 ASSVVYS-ATKDYKDHGYRHCSLAVINALANIAANIQEEHLVDELLMNLLELFVQLGLEG 686
Query: 4188 RRVGEXXXXX--XXXXXXSAGNLGVLMPKIASLLRRMQPISEPTTKLRSLFRDFWFYCTV 4015
+R E SAGNLGVL+P IA L RR+ PI E +L+ LFRDFW Y +
Sbjct: 687 KRASERASEKGPALKASSSAGNLGVLIPVIAVLTRRLPPIKEAKPRLQKLFRDFWLYSVL 746
Query: 4014 LGFDVESSSLWPEEWYNAVCETATKTPVLI--ATENLRSELIDNAAIRSDSISPQELQEM 3841
+GF VE S LWPEEWY VCE ATK+P+L + E LRS L N+A+++D+++ EL E+
Sbjct: 747 MGFAVEGSGLWPEEWYEGVCEIATKSPLLTFPSKEPLRSVLQYNSAMKNDTVTLAELSEL 806
Query: 3840 RNTVLAELSHQAEAVPLINRFDFANCTYLLSVHRMETMRLIHANHVDAFSSFFKYIEDKT 3661
R+T++ L E LIN+ DFA TYLLSV+R+E MR++ + D F F Y EDK
Sbjct: 807 RSTIINLLDPPPEVSALINKLDFAMSTYLLSVYRLEYMRVLRSTDPDRFQVMFCYFEDKA 866
Query: 3660 MRKDKSGLWTCMLAAAPRIFLEWCEKMMKRRDNDEPTEEALVWHAQFLLFKFNHHLREVR 3481
++KDKSG+ C++A A ++F + M ++ E EE L HAQFLL FNH + +R
Sbjct: 867 IQKDKSGMMQCVIAVADKVFDAFLNMMAEKAKTKE-NEEELERHAQFLLVNFNHIHKRIR 925
Query: 3480 KVADACLSQLVKAFPYLLWNTKVLTTILRLLQELEDNLQKDPTCREPQFTIEGFGGWTIQ 3301
+VAD LS LV FP+LLW+ VL T+L +LQ L +L D +P + I + I
Sbjct: 926 RVADKYLSGLVDKFPHLLWSGTVLKTMLDILQTLSLSLSADIHKDQPYYDIPD-APYRIT 984
Query: 3300 LQDSIEGRRSVVKDFSMRVKQILKEALRWAPASTHSNLLEYVSKF-----GSERDAAMQL 3136
+ D+ E R S+VKDF+ R IL+EA++WAP T S+L EY++K G + + +
Sbjct: 985 VPDTYEARESIVKDFAARCGMILQEAMKWAPTVTKSHLQEYLNKHQNWVSGLSQHTGLAM 1044
Query: 3135 AIDATSEGSGKS----------------------GSYLTSLYKRSNYLGQVKGMLATTLS 3022
A ++ +G + +++ SL R+ Y G+V GM+ S
Sbjct: 1045 ATESILHFAGYNKQNTTLGATQLTERPACVKKDYSNFMASLNLRNRYAGEVHGMIR--FS 1102
Query: 3021 GDIDQVTAENQLIDRLEKDFQRACKSGKDMEMEQAVLLLTALFVSLRSLNERILSLLVRT 2842
G Q++ N++ + +D A QA+ LTA+ +S + + ++L L
Sbjct: 1103 GATGQMSDLNKM---MVQDLITALDHSHPQHYTQAMFKLTAMLISSKDCDPQLLHHLCWG 1159
Query: 2841 PLLNFTESTVSLCTMAWNWLLSARPEAHSLFLHEQARAFADSSRFGLGLFEKEVVGGSPL 2662
PL F E + W WLL+ + F+ E A A+ + GLF E PL
Sbjct: 1160 PLRMFNEHGMETALACWEWLLAGKNGVEVPFMREMAGAWHMTVEQKFGLFSVETKEADPL 1219
Query: 2661 C-QKLERPPPSA-NFRPHREWIEFIGERCDVASYSSREQLDVLEMMFSQTLSAHIGTGHL 2488
+ +P P PH WI+F+ +R ++A Y S +Q+++ + +++S +IG
Sbjct: 1220 AASEASQPRPCPPEVTPHYIWIDFLVQRFEIAKYCSSDQVEIFSSLLQRSMSLNIGGAR- 1278
Query: 2487 HGSTACSNPASLAGPSRKETINQVTRGIEAVGVRFRLLSCVLGMVQQDACLLRPTNVLIR 2308
+ R + A+G RF+LL+ L ++ D ++R
Sbjct: 1279 ---------------------GSMNRHVAAIGPRFKLLTLGLSLLHADVVPNATIRNVLR 1317
Query: 2307 QRVYSCAFHYFTIAPQGPTQPEERLREDIRLLTRFFEHLKNDKHYMQKEALAKTDKNLVM 2128
+++YS AF YF+ P+ PTQ E+RLREDI ++ +F+ + +DK Y+ L D
Sbjct: 1318 EKIYSTAFDYFSCPPKFPTQGEKRLREDISIMIKFWTAMFSDKKYLTASQLVPPDNQDTR 1377
Query: 2127 SSTMSQMQTNFEKSLLISXXXXXXXXXXXXXTSLMLPPSTNYANTLTLSSQKSMAATSAS 1948
S+ + + + + + NT LSS S + S
Sbjct: 1378 SNLDITVGSRQQAT-------------------------QGWINTYPLSSGMS----TIS 1408
Query: 1947 IRSGKSIETKLSIEEDRRIKTWMKQRNMLMLLVANEIERLSAWLHPLALAQEDCALDSEE 1768
+SG S +T + K +MK+R +L+ L+A EIERL W +PL+ + + E
Sbjct: 1409 KKSGMSKKTNRGSQLH---KYYMKRRTLLLSLLATEIERLITWYNPLSAPELELDQAGEN 1465
Query: 1767 FLRGAFTQAKATGGEKNIWREQAQLAWDISPELAIQLPSRFRGSPELVKYVDVLVRGQPE 1588
+ A ++K + W++ LAW ISP LA+QLP+RF+ + + V LVR P
Sbjct: 1466 SV--ANWRSKYISLSEKQWKDNVNLAWSISPYLAVQLPARFKNTEAIGNEVTRLVRLDPG 1523
Query: 1587 PVAHIPEALPLFLGNGSTVFETSDMSHVLTWARCSPVMALSLLTPRIYPMHPISMQYAVR 1408
V+ +PEA+ + + + ++SHVL WA P LS + +YP HP++ QY V+
Sbjct: 1524 AVSDVPEAIKFLVTWHTIDADAPELSHVLCWAPTDPPTGLSYFSS-MYPPHPLTAQYGVK 1582
Query: 1407 VLRSYSADELLLYIPQIVQAVRYDTMGYISELIIWLAGHSQLLSHQLIWNMQTNMFTDEE 1228
VLRS+ D +L YIPQIVQA+RYD MGY+ E I+W A SQLL+HQ IWNM+TN++ DEE
Sbjct: 1583 VLRSFPPDAILFYIPQIVQALRYDKMGYVREYILWAAAKSQLLAHQFIWNMKTNIYLDEE 1642
Query: 1227 SKVKDPVLFEALNDIMQKILSQLEGAARRFHEAEFKLFHQLTAISGTIKPFPKGDARKKA 1048
KDP + + L ++++I L G A+ F++ EF F+++T +S IKP+PKGD RKKA
Sbjct: 1643 GHQKDPDIGDLLEQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPYPKGDERKKA 1702
Query: 1047 CLKALADVKIETITYLPSNPEAVLLDLDYSSGTPMQSAAKAPFLARFRVKRCGVRELEHI 868
CL AL++VK++ YLPSNPEA++LD+DY SGTPMQSAAKAP+LA+F+VKRCGV ELE
Sbjct: 1703 CLSALSEVKVQPGCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKE 1762
Query: 867 GLQAQSEHGGK--TTEADLEELKKVQDSRVCWQAAIFKVGDDVRXXXXXXXXXXXMKNVW 694
GLQ +S+ + + EAD ++CWQAAIFKVGDD R KN++
Sbjct: 1763 GLQCRSDAEDECFSQEAD--------GKKICWQAAIFKVGDDCRQDMLALQIIDLFKNIF 1814
Query: 693 AGLGLPVRVFPYRVVATSPGCGVIECVPNSKSRDQLGRQTDFGLYEYFKTQYGDESSETF 514
+GL + VFPYRVVAT+PGCGVIEC+P+ SRDQLGRQTDFG+Y+YF QYGDES+ F
Sbjct: 1815 QLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQLGRQTDFGMYDYFTRQYGDESTLAF 1874
Query: 513 QEARRNFVRSMAAYSVFSFLLQIKDRHNGNIMIDLDGHIIHIDFGFMFESSPGGNLGFEP 334
Q+AR NF+RSMAAYS+ FLLQIKDRHNGNIM+D GHIIHIDFGFMFESSPGGNLG+EP
Sbjct: 1875 QQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFMFESSPGGNLGWEP 1934
Query: 333 DFKLSEEMVAIMGGKMEAAPFRQFASLCVHAYLAVRPYHKSFVSLVSLMLDTHLPCFRGK 154
D KL++EMV IMGGKMEA PF+ F +CV YLAVRPY + VSLV+LMLDT LPCFRG+
Sbjct: 1935 DIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFRGQ 1994
Query: 153 TINQLRARFAPEMNEKDAAKYMYSVITNCFLNIRSKMYDQLQYFQNEIPY 4
TI L+ RF+P M E++AA ++ VI NCFL+ RS+ YD +QY+QN+IPY
Sbjct: 1995 TIKLLKHRFSPNMTEREAANFIMKVIQNCFLSNRSRTYDMIQYYQNDIPY 2044
>gi|27807043|ref|NP_777002.1| phosphatidylinositol 4-kinase,
catalytic, alpha polypeptide [Bos taurus]
gi|2198791|gb|AAC48730.1| phosphatidylinositol 4-kinase [Bos taurus]
Length = 2043
Score = 1244 bits (3220), Expect = 0.0
Identities = 785/2142 (36%), Positives = 1147/2142 (52%), Gaps = 83/2142 (3%)
Frame = -1
Query: 6180 LSHNVRCSLIAIANYLLHSHGQHADELVPMLLRALIALPHMKWIDDGLLNKS-DKIPIQE 6004
L R ++IA+ +L+ S QH D +VP LLR L LP + W+++ K +P+ E
Sbjct: 12 LDERRRDAVIALGIFLIESDLQHKDSVVPYLLRLLKGLPKVYWVEESTARKGRGTLPVAE 71
Query: 6003 QFSFCFNTSLSDLAAHLPRFRQQIVSAQADALACAVSSIYDVLEDQESLEHNYSHVIKLM 5824
SFC T LSD+A P R +I+ A L + + LE QE E+ H + +
Sbjct: 72 SLSFCLVTLLSDVAYRDPSLRGEILEALLQVLHVLLG-MCQALEIQEK-EYLCKHAVPCL 129
Query: 5823 CYALGLLRSIGRFSADYDTPLISLIFPLPVDETKKCKGAGGA------------------ 5698
LG++R+ GR S+ D+ L L P + + G
Sbjct: 130 ---LGIVRAFGRHSSSEDSLLSRLFPRAPAHSPRVPEELEGVRRRSFNDFRSILPSSLLT 186
Query: 5697 -----DIKHRISSDEFTFDTS-----------------CDASSSDPLLLTDSKSSRLIRM 5584
+K + SS S C +S P T +
Sbjct: 187 VCQEGSLKRKASSASSVAQVSPERGAPPPSPPGGSAFHCLEASYSPNGSTSESDYYFSAV 246
Query: 5583 YNKLGASFLLNNYTGGLKLTMSSEDLEKLFDSVQRLMDSKFLESLDXXXXXXXXXXXGVK 5404
+ L S L N T + ++ E L +L + V+++++ L+SLD
Sbjct: 247 SSSLSVSPLFNGVTYK-EFSIPLEMLRELLNLVKKIVEEPVLKSLDAVVTGVIEASPSAD 305
Query: 5403 RNPYKSMSEITNLCCLTLLKDVLGPYSVKNSDKNQENCGNSLQEASPSSPISE--KFAKE 5230
+ + S+ + L +L+D L Y +++ P+S + E F E
Sbjct: 306 LC-HGAFSDPLYVAVLRMLRDTL--YYMRDL---------------PTSFVKEVHDFVLE 347
Query: 5229 ISIFSKTALSKLDAXXXXXXXXXXXXXXXXXSRQKLNIQSATVCLQLXXXXXXXXXXXXX 5050
S+ L K+ S KL Q++ C+ L
Sbjct: 348 QFNSSQGELQKI--------LHDADRAHSELSPLKLRCQASAACVDLMVWAVKDEQGAEN 399
Query: 5049 ICTEIIVRLFANQTQKTIISQLPLYLKAISSMATLAEKFPAVATTAVIQNLQRFLLEPAP 4870
+C ++ +L + + K II+Q+PL + + + L E+FP V + V +L+ FL+ P+P
Sbjct: 400 LCVKLSEKLQSKTSSKVIIAQVPLLICCLQGLGRLCERFPVVVHS-VTPSLRDFLVVPSP 458
Query: 4869 MLTKLASDSTLERGKSAGDVI-----QHSKSSNNLIDAITKRKLSLDALRNSAIKAICRA 4705
+L KL + + D+ +H++S+ N+ + + LR+ AI +CR
Sbjct: 459 VLVKLYKCHSQYHTVAGNDIKISVTNEHAESTLNVASGKKSQPSMYEQLRDIAIDNVCRC 518
Query: 4704 LKSSIRMESDSVQQCLAGLSTKLFVCSNANNFVVSLVCENAIQTLGGIGVGLVDSTAVEV 4525
LK+ + + V+ LA LS +L++ S ++ L+ ++ I+ LG I V L D+ V
Sbjct: 519 LKAGLTEDPVIVEAFLASLSNRLYI-SQESDKDAHLIPDHTIRALGHIAVALRDTPKVME 577
Query: 4524 PEMVVQIYLQRFANPPSQLDVTMIRCLAEMWIAGARSIYENVWKLFTQICIESSNRVYSQ 4345
P ++QI Q+F PPS LDV +I L + I G + IY+ VW LF QI +++S+ VYS
Sbjct: 578 P--ILQILQQKFCQPPSPLDVLIIDQLGCLVITGNQYIYQEVWNLFQQISVKASSVVYS- 634
Query: 4344 GNNESNDQRYTHVSLAVDVAMSRMAAGVANEDDKMTXXXXXXXXXXXLGIEGRRVGEXXX 4165
+ D Y H SLAV A++ +AA + +E LG+EG+R E
Sbjct: 635 ATKDYKDHGYRHCSLAVINALANIAANIQDEHLVDELLMNLLELFVQLGLEGKRASERAS 694
Query: 4164 XX--XXXXXXSAGNLGVLMPKIASLLRRMQPISEPTTKLRSLFRDFWFYCTVLGFDVESS 3991
SAGNLGVL+P IA L RR+ PI EP +L+ LFRDFW Y ++GF VE S
Sbjct: 695 EKGPALKASSSAGNLGVLIPVIAVLTRRLPPIEEPKPRLQKLFRDFWLYSVLMGFAVEGS 754
Query: 3990 SLWPEEWYNAVCETATKTPVLI--ATENLRSELIDNAAIRSDSISPQELQEMRNTVLAEL 3817
LWPEEWY VCE ATK+P+L + E LRS L N+A+++D+++P EL E+R+T++ L
Sbjct: 755 GLWPEEWYEGVCEIATKSPLLTFPSKEPLRSVLQYNSAMKNDTVTPAELSELRSTIVNLL 814
Query: 3816 SHQAEAVPLINRFDFANCTYLLSVHRMETMRLIHANHVDAFSSFFKYIEDKTMRKDKSGL 3637
E LI + DFA TYLLSV+R+E MR++ ++ F Y EDK ++KDKSG+
Sbjct: 815 DPAPEVSALIGKLDFAMSTYLLSVYRLEYMRVLRSSDPARFQVMLCYFEDKAIQKDKSGM 874
Query: 3636 WTCMLAAAPRIFLEWCEKMMKRRDNDEPTEEALVWHAQFLLFKFNHHLREVRKVADACLS 3457
C++A A ++F + M ++ E EE + QFLL FNH + +R+VAD LS
Sbjct: 875 MQCVIAVADKVFDAFLNMMAEKAKTKENEEE--LERTQFLLVSFNHVHKRIRRVADKYLS 932
Query: 3456 QLVKAFPYLLWNTKVLTTILRLLQELEDNLQKDPTCREPQFTIEGFGGWTIQLQDSIEGR 3277
LV FP+LLW+ VL T+L +LQ L +L D +P + I + I + D+ E R
Sbjct: 933 GLVDKFPHLLWSGTVLKTMLDILQTLSLSLSADIHKDQPYYDIPDVP-YRITVPDTYEAR 991
Query: 3276 RSVVKDFSMRVKQILKEALRWAPASTHSNLLEYVSKF-----GSERDAAMQLAIDATSEG 3112
S+VKDF+ R IL+EA++WAP T S+L EY+SK G + + +A ++
Sbjct: 992 ESIVKDFAARCGMILQEAMKWAPTVTKSHLQEYLSKHQNWVSGLSQHTGLAMATESVLHY 1051
Query: 3111 SGKS----------------------GSYLTSLYKRSNYLGQVKGMLATTLSGDIDQVTA 2998
SG + +++ SL R+ Y +V GM+ + D
Sbjct: 1052 SGYNKQSTSLGATQLTERPACVKKDYSNFMASLNLRNRYAAEVYGMIRFS-----DATGH 1106
Query: 2997 ENQLIDRLEKDFQRACKSGKDMEMEQAVLLLTALFVSLRSLNERILSLLVRTPLLNFTES 2818
+ L + ++ + A +G + QA+ LTA+ +S R + ++L L PL F E
Sbjct: 1107 TSDLNKMMVQELKAALGAGDAQQYTQAMFKLTAMLISSRDCDPQLLHHLCWGPLQMFNEH 1166
Query: 2817 TVSLCTMAWNWLLSARPEAHSLFLHEQARAFADSSRFGLGLFEKEVVGGSPLC-QKLERP 2641
+ W WLL+ + F+ E A A+ + GLF E+ PL + +P
Sbjct: 1167 GMETALACWEWLLAGKNGVEVPFMREMAGAWQMTVEQKFGLFSAEMKEADPLAASEASQP 1226
Query: 2640 PPSA-NFRPHREWIEFIGERCDVASYSSREQLDVLEMMFSQTLSAHIGTGHLHGSTACSN 2464
P A PH WI+F+ +R ++A Y S +Q+++ + ++LS IG
Sbjct: 1227 KPCAPEVTPHYIWIDFLVQRFEIAKYCSSDQVEIFCSLLQRSLSLSIGG----------- 1275
Query: 2463 PASLAGPSRKETINQVTRGIEAVGVRFRLLSCVLGMVQQDACLLRPTNVLIRQRVYSCAF 2284
T + R + A+G RF+LL+ L ++ D ++R+++YS AF
Sbjct: 1276 -----------TAGSMNRHVAAIGPRFKLLTLGLSLLHADVLPNATIRNVLREKIYSTAF 1324
Query: 2283 HYFTIAPQGPTQPEERLREDIRLLTRFFEHLKNDKHYMQKEALAKTDKNLVMSSTMSQMQ 2104
YF+ P+ PTQ E+RLREDI ++ +F+ + +DK Y+ L D S+ +
Sbjct: 1325 DYFSCPPRFPTQGEKRLREDISVMIKFWTAMFSDKKYLTASQLVPPDNQDTRSNLDIAVG 1384
Query: 2103 TNFEKSLLISXXXXXXXXXXXXXTSLMLPPSTNYANTLTLSSQKSMAATSASIRSGKSIE 1924
+ + + + NT LSS S + S +SG S +
Sbjct: 1385 SRQQAT-------------------------QGWINTYPLSSGMS----TISKKSGMSKK 1415
Query: 1923 TKLSIEEDRRIKTWMKQRNMLMLLVANEIERLSAWLHPLALAQEDCALDSEEFLRGAFTQ 1744
T + K +MK+R +L+ L+A EIERL W +PL+ + + LD A +
Sbjct: 1416 TNRGSQLH---KYYMKRRTLLLSLLATEIERLITWYNPLSAPELE--LDQAGESSVANWR 1470
Query: 1743 AKATGGEKNIWREQAQLAWDISPELAIQLPSRFRGSPELVKYVDVLVRGQPEPVAHIPEA 1564
+K + W++ LAW ISP LA+QLP+RF+ + + V LVR P V+ +PEA
Sbjct: 1471 SKYISLSEKQWKDNVNLAWSISPHLAVQLPARFKNTEAIGNEVTRLVRLDPGAVSDVPEA 1530
Query: 1563 LPLFLGNGSTVFETSDMSHVLTWARCSPVMALSLLTPRIYPMHPISMQYAVRVLRSYSAD 1384
+ + + + ++SHVL WA P LS + + P HP++ QY V+VLRS+ D
Sbjct: 1531 IKFLVTWHTIDADAPELSHVLCWAPADPPTGLSYFSS-MSPPHPLTAQYGVKVLRSFPPD 1589
Query: 1383 ELLLYIPQIVQAVRYDTMGYISELIIWLAGHSQLLSHQLIWNMQTNMFTDEESKVKDPVL 1204
+L YIPQIVQA+RYD MGY+ E I+W A SQLL+HQ IWNM+TN++ DEE KDP +
Sbjct: 1590 AILFYIPQIVQALRYDKMGYVREYILWAASQSQLLAHQFIWNMKTNIYVDEEGHQKDPDI 1649
Query: 1203 FEALNDIMQKILSQLEGAARRFHEAEFKLFHQLTAISGTIKPFPKGDARKKACLKALADV 1024
+ L ++++I L G A+ F++ EF F+++T +S IKP+PKGD RKKACL AL++V
Sbjct: 1650 GDLLEQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPYPKGDERKKACLSALSEV 1709
Query: 1023 KIETITYLPSNPEAVLLDLDYSSGTPMQSAAKAPFLARFRVKRCGVRELEHIGLQAQS-- 850
K++ YLPSNPEA++LD+DY SGTPMQSAAKAP+LA+F+VKRCGV ELE GL+ +S
Sbjct: 1710 KVQPGCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEGLRCRSDP 1769
Query: 849 EHGGKTTEADLEELKKVQDSRVCWQAAIFKVGDDVRXXXXXXXXXXXMKNVWAGLGLPVR 670
E G EAD ++ WQAAIFKVGDD R KN++ +GL +
Sbjct: 1770 EEEGSMQEAD--------GQKISWQAAIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLF 1821
Query: 669 VFPYRVVATSPGCGVIECVPNSKSRDQLGRQTDFGLYEYFKTQYGDESSETFQEARRNFV 490
VFPYRVVAT+PGCGVIEC+P+ SRDQLGRQTDFG+Y+YF QYGDES+ FQ+AR NF+
Sbjct: 1822 VFPYRVVATAPGCGVIECIPDCTSRDQLGRQTDFGMYDYFTRQYGDESTLAFQQARYNFI 1881
Query: 489 RSMAAYSVFSFLLQIKDRHNGNIMIDLDGHIIHIDFGFMFESSPGGNLGFEPDFKLSEEM 310
RSMAAYS+ FLLQIKDRHNGNIM+D GH+IHIDFGFMFESSPGGNLG+EPD KL++EM
Sbjct: 1882 RSMAAYSLLLFLLQIKDRHNGNIMLDKKGHLIHIDFGFMFESSPGGNLGWEPDIKLTDEM 1941
Query: 309 VAIMGGKMEAAPFRQFASLCVHAYLAVRPYHKSFVSLVSLMLDTHLPCFRGKTINQLRAR 130
V IMGGKMEA PF+ F +CV YLAVRPY + VSLV+LMLDT LPCFRG+TI L+ R
Sbjct: 1942 VMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFRGQTIKLLKHR 2001
Query: 129 FAPEMNEKDAAKYMYSVITNCFLNIRSKMYDQLQYFQNEIPY 4
F+P M E++AA ++ VI NCFL+ RS+ YD +QY+QN+IPY
Sbjct: 2002 FSPNMTEREAANFILKVIQNCFLSNRSRTYDMIQYYQNDIPY 2043
>gi|50756213|ref|XP_415062.1| PREDICTED: similar to
phosphatidylinositol 4-kinase, catalytic, alpha
polypeptide isoform 2; phosphatidylinositol 4-kinase,
type II, alpha; phosphatidylinositol 4-kinase, type III,
alpha; phosphatidylinositol 4-kinase 230 [Gallus gallus]
Length = 2149
Score = 1232 bits (3187), Expect = 0.0
Identities = 789/2178 (36%), Positives = 1154/2178 (52%), Gaps = 119/2178 (5%)
Frame = -1
Query: 6180 LSHNVRCSLIAIANYLLHSHGQHADELVPMLLRALIALPHMKWIDDGLLNKS-DKIPIQE 6004
L R ++IA+ +L+ S QH D +VP LLR L LP ++WI++ K +P+ E
Sbjct: 91 LDERRRDAVIALGIFLIESDLQHKDNVVPYLLRLLKGLPKVQWIEESSARKGRGLLPVAE 150
Query: 6003 QFSFCFNTSLSDLAAHLPRFRQQIVSAQADALACAVSSIYDVLEDQESLEHNYSHVIKLM 5824
FSFC T LSD+A R+QI+ DA+ + + + + + + Y +
Sbjct: 151 NFSFCLVTLLSDVAYRDASLREQIL----DAVLQVMQFLLGMCQTPQMHDKEYLCKYAVP 206
Query: 5823 CYALGLLRSIGRFSADYDTPLISLIFP---------------------------LPVDET 5725
C +G+ R+ GR+S + + L+S +FP LP
Sbjct: 207 CL-IGISRAFGRYS-NSEEALLSKLFPKIPPHSLRVPEELEGIRRRSFNDFRSILPSSLL 264
Query: 5724 KKCKGAGGADIKHRISSDEFTFDTSCDASSSDPL-------------LLTDSKSSRLIRM 5584
C+ +K + SS S + P L D +
Sbjct: 265 MVCQEG---TLKRKASSVSSISQVSPERGIPPPSSPGGSTIHYFEGSYLPDGSAVDPEYY 321
Query: 5583 YNKLGASFLLNNYTGGL---KLTMSSEDLEKLFDSVQRLMDSKFLESLDXXXXXXXXXXX 5413
+ + +SF ++ G+ + + E L +L + V+++++ L++LD
Sbjct: 322 FTTISSSFSVSPLFNGINNKEFNIPLEMLRQLLNMVKQIVEDSLLKTLDAVVAELAEMGT 381
Query: 5412 GVKRNPYKSMSEITNLCCLTLLKDVLGPYSVKNSDKNQENCGNSLQEASPSSPISEKFAK 5233
YK+ S+ L +L+D L Y +K+ + F K
Sbjct: 382 NTDIY-YKTFSDPLYLAQFKMLRDTL--YYMKD--------------------LPNSFVK 418
Query: 5232 EISIF-------SKTALSKLDAXXXXXXXXXXXXXXXXXSRQKLNIQSATVCLQLXXXXX 5074
EI F S++ L K+ S KL Q+ C+ L
Sbjct: 419 EIHDFVLEQFNSSQSELQKI--------LHDVDRLHNELSPLKLRCQANAACVDLMVWAV 470
Query: 5073 XXXXXXXXICTEIIVRLFANQTQKTIISQLPLYLKAISSMATLAEKFPAVATTAVIQNLQ 4894
+C ++ +L + + K II+ LPL + + + L E+FP V + V +L+
Sbjct: 471 KDEQGAENLCIKLSEKLQSKTSSKVIIAHLPLLICCLQGLGRLCERFPVVVHS-VNPSLR 529
Query: 4893 RFLLEPAPMLTKLASDSTLERGKSAGDVI-----QHSKSSNNLIDAITKRKLSLDALRNS 4729
FL+ P+P+L KL + A D+ +HS+S+ N++ + + LR+
Sbjct: 530 DFLVIPSPVLVKLYKYHSQYHTVGANDIKISVTNEHSESTLNVMPGKRSQPSMYEQLRDI 589
Query: 4728 AIKAICRALKSSIRMESDSVQQCLAGLSTKLFVCSNANNFVVSLVCENAIQTLGGIGVGL 4549
AI ICR LK+ + ++S V+ LA LS +L++ S ++ L+ ++ I+ LG I V L
Sbjct: 590 AIDNICRCLKAGLTIDSVIVEAFLASLSNRLYI-SQESDKEAHLIPDHTIRALGHIAVAL 648
Query: 4548 VDSTAVEVPEMVVQIYLQRFANPPSQLDVTMIRCLAEMWIAGARSIYENVWKLFTQICIE 4369
D+ + P ++QI Q+F PPS LDV +I L + I G + IY+ VW LF QI ++
Sbjct: 649 RDTPKMMEP--ILQILQQKFCQPPSNLDVLIIDQLGCLVITGNQYIYQEVWNLFQQISVK 706
Query: 4368 SSNRVYSQGNNESNDQRYTHVSLAVDVAMSRMAAGVANEDDKMTXXXXXXXXXXXLGIEG 4189
+S+ VYS + D Y H SLAV A++ +AA + E LG+EG
Sbjct: 707 ASSVVYS-ATKDYKDHGYRHCSLAVINALANIAANIQGEHLVDELLMNLLELFVQLGLEG 765
Query: 4188 RRVGEXXXXXXXXXXXSAG---------NLGVLMPKI------------------ASLLR 4090
+R E A + G + K +L R
Sbjct: 766 KRASERASEKGPALKIEAKVCIEDIKTLDSGFALEKFQNISLLNFRNYVWSSIDNVTLTR 825
Query: 4089 RMQPISEPTTKLRSLFRDFWFYCTVLGFDVESSSLWPEEWYNAVCETATKTPVLI--ATE 3916
R+ PI E +L+ LFRDFW Y ++GF VE S LWPEEWY VCE ATK+P+L + E
Sbjct: 826 RLPPIKEAKPRLQKLFRDFWLYSVLMGFAVEGSGLWPEEWYEGVCEIATKSPLLTFPSKE 885
Query: 3915 NLRSELIDNAAIRSDSISPQELQEMRNTVLAELSHQAEAVPLINRFDFANCTYLLSVHRM 3736
LRS L N+A+++D+++ EL E+R+T++ L E LIN+ DFA TYLLSV+R+
Sbjct: 886 PLRSVLQYNSAMKNDTVTSAELNELRSTIINLLDPPPEVSALINKLDFAMSTYLLSVYRL 945
Query: 3735 ETMRLIHANHVDAFSSFFKYIEDKTMRKDKSGLWTCMLAAAPRIFLEWCEKMMKRRDNDE 3556
E MR++ + D F F Y EDK ++KDKSG+ C++A A ++F E MM + +
Sbjct: 946 EYMRVLRSTDQDRFQVMFCYFEDKAIQKDKSGMMQCVIAVADKVF-EAFLTMMADKPKTK 1004
Query: 3555 PTEEALVWHAQFLLFKFNHHLREVRKVADACLSQLVKAFPYLLWNTKVLTTILRLLQELE 3376
EE L HAQFLL FNH + +R+VAD LS LV FP+LLW+ VL T+L +LQ L
Sbjct: 1005 ENEEELERHAQFLLVNFNHIHKRIRRVADKYLSGLVDKFPHLLWSGTVLKTMLDILQTLS 1064
Query: 3375 DNLQKDPTCREPQFTIEGFGGWTIQLQDSIEGRRSVVKDFSMRVKQILKEALRWAPASTH 3196
+L D +P + I + I + D+ E R S+VKDF+ R IL+EA++WAP+ T
Sbjct: 1065 LSLSADIHKDQPYYDIPD-APYRITVPDTHEARESIVKDFAARCGMILQEAMKWAPSVTK 1123
Query: 3195 SNLLEYVSKF-----GSERDAAMQLAIDATSEGSGKS----------------------G 3097
S+L EY++K G + + +A ++ +G +
Sbjct: 1124 SHLQEYLNKHQNWVSGLSQHTGLAMATESVLHFAGYNRQNTTLGATQLTERPTCVKKDYS 1183
Query: 3096 SYLTSLYKRSNYLGQVKGML----ATTLSGDIDQVTAENQLIDRLEKDFQRACKSGKDME 2929
+++ SL R+ Y G+V GM+ AT + D++++ + K+ A +SG+
Sbjct: 1184 NFMASLNLRNRYAGEVSGMIQFSNATGRTSDLNKL---------MVKELNNALESGQTEF 1234
Query: 2928 MEQAVLLLTALFVSLRSLNERILSLLVRTPLLNFTESTVSLCTMAWNWLLSARPEAHSLF 2749
QA+ LTAL +S + + ++L L PL F E + W WLL+A+ F
Sbjct: 1235 YTQAMFKLTALLISSKDCDPQLLHHLCWGPLQMFNEHGMETAIACWEWLLAAKNGIEVPF 1294
Query: 2748 LHEQARAFADSSRFGLGLFEKEVVGGSPLCQKLERPPPSA--NFRPHREWIEFIGERCDV 2575
+ E A A+ + +GLF E PL E P PH WIEF+ +R ++
Sbjct: 1295 MREMAGAWQMTVEQKVGLFSAEQKEADPLAASEESQPRPCPPEVTPHYIWIEFLVQRFEI 1354
Query: 2574 ASYSSREQLDVLEMMFSQTLSAHIGTGHLHGSTACSNPASLAGPSRKETINQVTRGIEAV 2395
A Y S +Q+++ + ++LS +IG K ++N R + A+
Sbjct: 1355 AKYCSSDQIEIFSSLLQRSLSLNIG-------------------GAKGSLN---RHVAAI 1392
Query: 2394 GVRFRLLSCVLGMVQQDACLLRPTNVLIRQRVYSCAFHYFTIAPQGPTQPEERLREDIRL 2215
G RF+LL+ L ++ D ++R+++YS AF YF+ + PTQ E+RLREDI +
Sbjct: 1393 GPRFKLLTLGLSLLHADVVPNATIRNVLREKIYSTAFDYFSWPSKFPTQGEKRLREDISI 1452
Query: 2214 LTRFFEHLKNDKHYMQKEALAKTDKNLVMSSTMSQMQTNFEKSLLISXXXXXXXXXXXXX 2035
L +F+ + +DK Y+ L D T S + N
Sbjct: 1453 LIKFWTAMFSDKKYLTANQLVPPDNQ----DTRSNLDINVGSRQ---------------- 1492
Query: 2034 TSLMLPPSTNYANTLTLSSQKSMAATSASIRSGKSIETKLSIEEDRRIKTWMKQRNMLML 1855
+ + NT LSS S + S +SG S +T + K +MK+R +L+
Sbjct: 1493 -----QATQGWINTYPLSSGMS----TISKKSGMSKKTNRGTQLH---KYYMKRRTLLLS 1540
Query: 1854 LVANEIERLSAWLHPLALAQEDCALDSEEFLRGAFTQAKATGGEKNIWREQAQLAWDISP 1675
L+A EIERL W +PL+ + LD A ++K + W++ LAW ISP
Sbjct: 1541 LLATEIERLITWYNPLS--SPELELDQTGESSVANWRSKYVSLSEKQWKDNVNLAWSISP 1598
Query: 1674 ELAIQLPSRFRGSPELVKYVDVLVRGQPEPVAHIPEALPLFLGNGSTVFETSDMSHVLTW 1495
LA+QLP+RF+ + + V LVR P V+ +PEA+ + + + ++SHVL W
Sbjct: 1599 HLAVQLPTRFKNTEAIGTEVTRLVRLDPGAVSDVPEAIKYLVTWHTIDADAPELSHVLCW 1658
Query: 1494 ARCSPVMALSLLTPRIYPMHPISMQYAVRVLRSYSADELLLYIPQIVQAVRYDTMGYISE 1315
A P LS + +YP HP++ QY V+VLRS+ D +L YIPQIVQA+RYD MGY+ E
Sbjct: 1659 APTDPPTGLSYFSS-MYPPHPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYDKMGYVRE 1717
Query: 1314 LIIWLAGHSQLLSHQLIWNMQTNMFTDEESKVKDPVLFEALNDIMQKILSQLEGAARRFH 1135
I+W A SQLL+HQ IWNM+TN++ DEE KDP + E L ++++I L G A+ F+
Sbjct: 1718 YILWAAAKSQLLAHQFIWNMKTNIYLDEEGHQKDPDIGELLEQLVEEITGSLSGPAKEFY 1777
Query: 1134 EAEFKLFHQLTAISGTIKPFPKGDARKKACLKALADVKIETITYLPSNPEAVLLDLDYSS 955
+ EF F+++T +S IKPFPKGD RKKACL AL++VK++ YLPSNPEA++LD+DY S
Sbjct: 1778 QREFDFFNKITNVSAIIKPFPKGDERKKACLSALSEVKVQPGCYLPSNPEAIVLDIDYKS 1837
Query: 954 GTPMQS-AAKAPFLARFRVKRCGVRELEHIGLQAQSEHGGKTTEADLEELKKVQDSRVCW 778
GTPMQ AAKAP+LA+F+VKRCGV ELE GL+ +S+ ++ E + V ++CW
Sbjct: 1838 GTPMQRCAAKAPYLAKFKVKRCGVSELEKEGLRCRSDSIDESAE------EGVDSKKICW 1891
Query: 777 QAAIFKVGDDVRXXXXXXXXXXXMKNVWAGLGLPVRVFPYRVVATSPGCGVIECVPNSKS 598
QAAIFKVGDD R KN++ +GL + VFPYRVVAT+PGCGVIEC+P+ S
Sbjct: 1892 QAAIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTS 1951
Query: 597 RDQLGRQTDFGLYEYFKTQYGDESSETFQEARRNFVRSMAAYSVFSFLLQIKDRHNGNIM 418
RDQLGRQTDFG+Y+YF QYGDES+ FQ+AR NF+RSMAAYS+ FLLQIKDRHNGNIM
Sbjct: 1952 RDQLGRQTDFGMYDYFTRQYGDESTLAFQKARYNFIRSMAAYSLLLFLLQIKDRHNGNIM 2011
Query: 417 IDLDGHIIHIDFGFMFESSPGGNLGFEPDFKLSEEMVAIMGGKMEAAPFRQFASLCVHAY 238
+D GHIIHIDFGFMFESSPGGNLG+EPD KL++EMV IMGGKMEA PF+ F +CV Y
Sbjct: 2012 LDKKGHIIHIDFGFMFESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGY 2071
Query: 237 LAVRPYHKSFVSLVSLMLDTHLPCFRGKTINQLRARFAPEMNEKDAAKYMYSVITNCFLN 58
LAVRPY + VSLV+LMLDT LPCFRG+TI L+ RF+P M E++AA ++ +I NCFL+
Sbjct: 2072 LAVRPYMDAVVSLVTLMLDTGLPCFRGQTIKLLKHRFSPNMTEREAATFIIKIIQNCFLS 2131
Query: 57 IRSKMYDQLQYFQNEIPY 4
RS+ YD +QY+QN+IPY
Sbjct: 2132 NRSRTYDMIQYYQNDIPY 2149
>gi|31231338|ref|XP_318507.1| ENSANGP00000021188 [Anopheles gambiae]
gi|21301624|gb|EAA13769.1| ENSANGP00000021188 [Anopheles gambiae str.
PEST]
Length = 2077
Score = 1211 bits (3132), Expect = 0.0
Identities = 782/2185 (35%), Positives = 1170/2185 (52%), Gaps = 76/2185 (3%)
Frame = -1
Query: 6330 QCLAICIAQV--SFWARNSIKIEFFQNENTKLSQIFNLLALDDKEEQFEAQPLSHNVRCS 6157
QCLA +A + + W + ++ EN + LD + + +
Sbjct: 24 QCLARVLAMIKPTPWEKVQTLFKYCPQENAA-----GVFCLDARAQD------------A 66
Query: 6156 LIAIANYLLHSHGQHADELVPMLLRALIALPHMKWIDDGLLNKSDKIPIQEQFSFCFNTS 5977
+IA+ Y L S Q+ E++P LLR ALP WIDD NK DKIP E+F+FC N+
Sbjct: 67 VIALGLYFLESGYQYPKEIIPYLLRLAKALPKAVWIDDVKPNKIDKIPTAEKFAFCLNSL 126
Query: 5976 LSDLAAHLPRFRQQIVSAQADALACAVSSIYDVLEDQESLEHNYSHVIKLMCYA-----L 5812
LSD+A P R +I+ Q + L + I + S E + I ++C A L
Sbjct: 127 LSDIAVGCPEHRDEIILIQVEVLTVLTNMI------KGSKESSTLPPI-ILCKATVPLLL 179
Query: 5811 GLLRSIGRFSADYDTPLISLIFPLPVDETKKCKGAG---GADIKHRISSDEF-------- 5665
GL RS+GR++A D PL+ +FP DE K A AD K S +F
Sbjct: 180 GLSRSMGRYAA-CDPPLLCRLFPK--DEILVIKSAETPLSADAKDSTSVSQFRSIIPRSM 236
Query: 5664 TFDTSCDASSSDPLLLTDSKSSRLIRMYN-----------KLGASF-------LLNNYTG 5539
+ S DA ++ + + K +L Y+ K G+SF ++
Sbjct: 237 SGSLSVDAGETEKSIHSSRK--KLSSFYSVPYDPTTYFFAKYGSSFNQFPNMRFCDSMEK 294
Query: 5538 GLKLTMSSEDLEKLFDSVQRLMDSKFLESLDXXXXXXXXXXXGVKRNPYKSMSEITNLCC 5359
+L L+ +F ++L+ + LE LD +K YKS SE NL
Sbjct: 295 NDRLQFPINHLQTIFALAKKLLTKETLEHLDEQAGDIYALNQ-IKPYGYKSFSETINLVM 353
Query: 5358 LTLLKDVLGPYSVKNSDKNQENCGNSLQEASPSSPISEKFAKEISIFSKTALSKLDAXXX 5179
+TLL+++L N +P + ++F K + + +T L
Sbjct: 354 VTLLREILQ---------------NQTDLPTPFTKDVQEFVKRLFLIGQTELQNKQ---H 395
Query: 5178 XXXXXXXXXXXXXXSRQKLNIQSATVCLQLXXXXXXXXXXXXXICTEIIVRLFANQTQKT 4999
++ K+N+ + C+ L +C+ + +L + K
Sbjct: 396 DAIDRVRDPSNIVVNKYKINVMANAACVDLLVWAIGDETEADKLCSRLYQKLNSVLGHKV 455
Query: 4998 IISQLPLYLKAISSMATLAEKFPAVATTAVIQNLQRFLLEPAPMLTKLASDSTLERGKSA 4819
++ +PL + + + LA+KFP +A T+ I L+ FL++P+P+LTKL S + K
Sbjct: 456 VMDHMPLLMVCLEGLGKLAQKFPNIAGTS-ISYLRDFLVDPSPILTKLHVQSQAQTKKDK 514
Query: 4818 GDV---IQHSKSSNNLIDAITKRK-------LSLDALRNSAIKAICRALKSSIRMESDSV 4669
+ I S D TK K + +ALR++AI+ + AL+++ ++ V
Sbjct: 515 ENAPFRIVVQGSDFKAFDHATKPKGLTKSAQEAFEALRDAAIENLSIALRAAHALDQYCV 574
Query: 4668 QQCLAGLSTKLFVCSNANNFVVSLVCENAIQTLGGIGVGLVDSTAVEVPEMVVQIYLQRF 4489
+A +S +LF + SLV N I LG + V L D+ + ++Q ++QRF
Sbjct: 575 PALVANVSNRLFTAEKQES-ESSLVSLNIIVMLGHVAVALKDTP--KTTNNILQFFIQRF 631
Query: 4488 ANPPSQLDVTMIRCLAEMWIAGAR-SIYENVWKLFTQICIESSNRVYSQGNNESNDQRYT 4312
PS+ +V ++ L M I+ ++E + K+F+++ +++++ YS N + Y
Sbjct: 632 CKVPSEQNVLIVDQLGCMIISKCEPQVFEEIMKMFSRVTVQAASLAYS--TNPEQRKSYH 689
Query: 4311 HVSLAVDVAMSRMAAGVANEDDKMTXXXXXXXXXXXLGIEGRRVGEXXXXXXXXXXXSAG 4132
HVS AV A++ +AA + E + + +G+E R + AG
Sbjct: 690 HVSDAVVNALANIAANIQGELEMLDLLGKLLELFVQIGLEAERSSDSTSGAQKASSS-AG 748
Query: 4131 NLGVLMPKIASLLRRMQPISEPTTKLRSLFRDFWFYCTVLGFDVESSSLWPEEWYNAVCE 3952
NLG+L+P IA L+RR+ PI P +L LF+DFW YC V+GF +S LWP +WY V +
Sbjct: 749 NLGMLIPVIAVLVRRLPPIKNPKQRLHKLFKDFWLYCVVMGFT--NSRLWPSDWYQGVQQ 806
Query: 3951 TATKTPVLIATENLRSELID---NAAIRSDSISPQELQEMRNTVLAELSHQ-AEAVPLIN 3784
A K+P+LI+ RSE+ + +AIRS S+S L E+RN +L L H A+ IN
Sbjct: 807 IAAKSPLLISQTAHRSEMRELNYTSAIRSGSVS---LMELRNQILLLLDHPPADITACIN 863
Query: 3783 RFDFANCTYLLSVHRMETMRLIHANHVDAFSSFFKYIEDKTMRKDKSGLWTCMLAAAPRI 3604
+ FA C YLLSV+ +E +R+ +A+ + Y+ D + KDK G+W C+ ++
Sbjct: 864 KLTFAQCAYLLSVYWLEILRVENASE-PSLEPILSYLCDNALLKDKYGMWQCVRCIGDQV 922
Query: 3603 FLEWCEKMMKRRDNDEPTEEALVWHAQFLLFKFNHHLREVRKVADACLSQLVKAFPYLLW 3424
F ++ ++ + D E+ L A LL FNH ++++ VAD LSQLV FP+LLW
Sbjct: 923 FEKFRSVLLAQ---DSVREKVLESQAMLLLVYFNHIHKQIQLVADQYLSQLVDKFPHLLW 979
Query: 3423 NTKVLTTILRLLQELEDNLQKDPTCREPQFTIEGFGGWTIQLQDSIEGRRSVVKDFSMRV 3244
N KVL +L +LQ L +L DP P + +T+QL DS+ R S VKDF+ R
Sbjct: 980 NRKVLWCMLDVLQLLAFSLTLDPNEETPTLRVNSTP-YTLQLMDSLPARESRVKDFADRC 1038
Query: 3243 KQILKEALRWAPASTHSNLLEYVSKFGS---ERDAAMQLAID---------ATSEGSGK- 3103
+ I+ EA++WAP ST S+L EY ++ S + + LA+D AT + K
Sbjct: 1039 QGIVNEAMKWAPKSTRSHLQEYPNQVPSTSLSNHSGLALAVDSILHTWVANATIPTATKR 1098
Query: 3102 -------SGSYLTSLYKRSNYLGQVKGMLATTLSGDIDQVTAENQLIDRLEKDFQRACKS 2944
+ +++ L RS Y G++ G+L+ + + L DRL +D AC
Sbjct: 1099 PHCVNSDTSKFVSVLCLRSKYAGEISGLLSVLEDEE------KKGLADRLVRDVWDACAE 1152
Query: 2943 GKDMEMEQAVLLLTALFVSLRSLNERILSLLVRTPLLNFTESTVSLCTMAWNWLLSARPE 2764
D + A+ TA + S N ++L + + + FTES + W W+L+AR +
Sbjct: 1153 KSDPKHRGALWRATAYLILCSSANRKLLHAISSSQVQLFTESAMETAVECWQWILTARQD 1212
Query: 2763 AHSLFLHEQARAFADSSRFGLGLFEKEVVGGSPL-----CQKLERPPPSANFRPHREWIE 2599
F+ E A+ + +GLF +E SPL C+ + +P A PH W++
Sbjct: 1213 LELCFIQEMVTAWQTTFDKRMGLFSEEHDVTSPLAAYEGCRLVPKPIVVA---PHLIWLQ 1269
Query: 2598 FIGERCDVASYSSREQLDVLEMMFSQTLSAHIGTGHLHGSTACSNPASLAGPSRKETINQ 2419
+ E D A Y +R+++++ M+ + L P ++ +
Sbjct: 1270 LLSEMVDTAKYCNRDKVEMFCMLLHRCL-----------------------PFSRDF--K 1304
Query: 2418 VTRGIEAVGVRFRLLSCVLGMVQQDACLLRPTNVLIRQRVYSCAFHYFTIAPQGPTQPEE 2239
R I VG RF+LL C L ++Q + ++R+R+Y+ A YF P+QP E
Sbjct: 1305 QNRHISTVGCRFKLLQCGLSLLQGNTIPKSLARNILRERIYANALDYFCGPQLCPSQPRE 1364
Query: 2238 RLREDIRLLTRFFEHLKNDKHYMQKEALAKTDKNLVMSSTMSQMQTNFEKSLLISXXXXX 2059
L EDI +L +F++ ++++K ++ ++ + + S +S + + + L
Sbjct: 1365 ALLEDIAILLKFWQTMRSEKKHLVASEVSDYELHTA-SVNLSVQKVSLDTVSLAGSEVAR 1423
Query: 2058 XXXXXXXXTSLMLPPSTNYANTLTLSSQKSMAATSASIRSGKSIETKLSIEEDRRIKTWM 1879
+P ST+ TLS + SA I+ + +D K +M
Sbjct: 1424 STSSGNAGWYNTIPHSTS-----TLSKR------SARIK-------RPPYPKDAYDKDYM 1465
Query: 1878 KQRNMLMLLVANEIERLSAWLHPLALAQEDCALDSEEFLRGAFTQAKATGGEKNIWREQA 1699
K+RN+++ L+A EIE + W +PLAL + + EE + + +A + N+WR+
Sbjct: 1466 KKRNLILELLAVEIEFMLIWANPLALPE--LQIPGEE----SVAEWRARPMKLNVWRDFT 1519
Query: 1698 QLAWDISPELAIQLPSRFRGSPELVKYVDVLVRGQPEPVAHIPEALPLFLGNGSTVFETS 1519
+LAW +P LA+ LP R R + + V LV P HIPEAL + + + E
Sbjct: 1520 RLAWSYNPALAVFLPQRIRNAETIEDEVTRLVCSDPMAAVHIPEALKYLVTTKTVLNEAP 1579
Query: 1518 DMSHVLTWARCSPVMALSLLTPRIYPMHPISMQYAVRVLRSYSADELLLYIPQIVQAVRY 1339
++ ++LTWAR +P+ ALS + R YP HP++ QYAV+ L SY A+ +L YIPQ+VQA+R+
Sbjct: 1580 ELVYMLTWARVNPIQALSYFS-RQYPTHPLTAQYAVKTLNSYPAEAVLPYIPQLVQALRH 1638
Query: 1338 DTMGYISELIIWLAGHSQLLSHQLIWNMQTNMFTDEESKVKDPVLFEALNDIMQKILSQL 1159
DTMGY++ELI ++ SQ+++HQL+WNMQTNM+ DEE +D L++AL + Q I+S L
Sbjct: 1639 DTMGYVTELIKHISKRSQIVAHQLVWNMQTNMYIDEEMHHRDS-LYDALESLSQNIISSL 1697
Query: 1158 EGAARRFHEAEFKLFHQLTAISGTIKPFPKGDARKKACLKALADVKIETITYLPSNPEAV 979
G A+RF+E EF F ++TA+SG I+ FPKG ARKKACL+AL+ +K+++ YLPSNPEA+
Sbjct: 1698 SGPAKRFYEREFDFFGKITAVSGEIRSFPKGQARKKACLEALSRIKVQSGCYLPSNPEAM 1757
Query: 978 LLDLDYSSGTPMQSAAKAPFLARFRVKRCGVRELEHIGLQAQSEHGGKTTEADLEELKKV 799
+LD+DY+SGTPMQSAAKAP+LARFRV+RCG+ ELE + ++ + + L L
Sbjct: 1758 VLDIDYNSGTPMQSAAKAPYLARFRVQRCGITELETMAMEVSNNPDSQIDGPRLNSL--- 1814
Query: 798 QDSRVCWQAAIFKVGDDVRXXXXXXXXXXXMKNVWAGLGLPVRVFPYRVVATSPGCGVIE 619
WQAAIFKVGDDVR KNV+ +GL + +FPYRVVAT+PGCGVIE
Sbjct: 1815 --GPEAWQAAIFKVGDDVRQDMLALQVISIFKNVFQQVGLELYLFPYRVVATAPGCGVIE 1872
Query: 618 CVPNSKSRDQLGRQTDFGLYEYFKTQYGDESSETFQEARRNFVRSMAAYSVFSFLLQIKD 439
CVPN+KSRDQLGRQTDFGLYEYF QYGDE+S+ FQ AR NFV+SMAAYSV +LLQIKD
Sbjct: 1873 CVPNAKSRDQLGRQTDFGLYEYFLHQYGDETSKEFQSARSNFVKSMAAYSVIGYLLQIKD 1932
Query: 438 RHNGNIMIDLDGHIIHIDFGFMFESSPGGNLGFEPDFKLSEEMVAIMGGKMEAAPFRQFA 259
RHNGNIMID DGHIIHIDFGFMFESSPGGN+GFEPD KL++EMV +MGGKMEAAPF+ F
Sbjct: 1933 RHNGNIMIDKDGHIIHIDFGFMFESSPGGNIGFEPDLKLTDEMVMVMGGKMEAAPFKWFC 1992
Query: 258 SLCVHAYLAVRPYHKSFVSLVSLMLDTHLPCFRGKTINQLRARFAPEMNEKDAAKYMYSV 79
LCV ++LA+RPY + V+LVSLMLDT LPCFRG+TI L+ RF P N K+AA +M V
Sbjct: 1993 DLCVQSFLAIRPYQDAIVTLVSLMLDTGLPCFRGQTITLLKQRFVPTKNSKEAAAHMLGV 2052
Query: 78 ITNCFLNIRSKMYDQLQYFQNEIPY 4
I N + N R++ YD +QY+QN+IPY
Sbjct: 2053 IRNSYQNFRTRTYDMIQYYQNQIPY 2077
>gi|47228503|emb|CAG05323.1| unnamed protein product [Tetraodon
nigroviridis]
Length = 2216
Score = 1173 bits (3034), Expect = 0.0
Identities = 736/1988 (37%), Positives = 1063/1988 (53%), Gaps = 160/1988 (8%)
Frame = -1
Query: 5487 VQRLMDSKFLESLDXXXXXXXXXXXGVKRNPYKSMSEITNLCCLTLLKDVLGPYSVKNSD 5308
V++ + +FL+SLD G+ + YK+ S+ + +L+D L +D
Sbjct: 318 VEQFVSEQFLKSLDDGLGEVLELNPGLHLH-YKTFSDPLYVAIFKMLRDTLYNLKDLQTD 376
Query: 5307 KNQENCGNSLQEASPSSPISEKFAKEISIFSKTALSKLDAXXXXXXXXXXXXXXXXXSRQ 5128
+E L++ S S ++ ++ + ++ LS L
Sbjct: 377 YVKEVHDFVLEQFSSSQSELQRILHDVE-YLQSELSPL---------------------- 413
Query: 5127 KLNIQSATVCLQLXXXXXXXXXXXXXICTEIIVRLFANQTQKTIISQLPLYLKAISSMAT 4948
KL Q+ C+ + +CT++ +L + + K II+ +PL + + +
Sbjct: 414 KLRCQANAACVDIMVWAVTEEQGAENLCTKLSEKLQSKTSSKVIIAHMPLLICCLQGLGR 473
Query: 4947 LAEKFPAVATTAVIQNLQRFLLEPAPMLTKLA---------------------SDSTLER 4831
L E+FP VA + V +L+ FL+ P+P+L KL S STL
Sbjct: 474 LCERFPVVAHS-VTMSLRDFLVVPSPVLVKLYKYHSQYTPGGSEIKIHVTNEHSQSTLSA 532
Query: 4830 GKS--------------AGDVIQHSKSSNNLIDAITKRKLSLDALRNSAIKAICRALKSS 4693
S A D I S N + T +LS+ + +CR LK+
Sbjct: 533 HSSKKSQPSMYEQLRDIAIDNICRSVHHNATRVSHTHTRLSVALIHYGICVLLCRCLKAG 592
Query: 4692 IRMESDSVQQCLAGLSTKLFVCSNANNFVVSLVCENAIQTLGGIGVGLVDSTAVEVPEMV 4513
+ M++ V+ LA LS +L++ N+ L+ ++ I+ LG I V L D+ V P +
Sbjct: 593 LTMDNVIVEAFLASLSNRLYIYQE-NDKDAHLIPDHTIRALGHIAVALRDTPRVMEP--I 649
Query: 4512 VQIYLQRFANPPSQLDVTMIRCLAEMWIAGARSIYENVWKLFTQICIESSNRVYSQGNNE 4333
+QI Q+F PPSQLDV +I L M I G + IY+ VW LF QI +++S+ VYS +
Sbjct: 650 LQILQQKFCQPPSQLDVLIIDQLGCMVITGNQYIYQEVWNLFQQISVKASSMVYS--TKD 707
Query: 4332 SNDQRYTHVSLAVDVAMSRMAAGVANEDDKMTXXXXXXXXXXXLGIEGRRVGEXXXXX-- 4159
D Y H SLAV A+ +AA + E LG+EG+R E
Sbjct: 708 YKDHGYRHCSLAVINALGNIAANLQAEQMVDELLVNLLELFVQLGLEGKRASERASDKGP 767
Query: 4158 XXXXXXSAGNLGVLMPKIASLLRRMQPISEPTTKLRSLFRDFWFYCTVLGFDVESSSLWP 3979
SAGNLGVL+P IA L +R+ PI E +L+ LFRDFW Y V+GF VE S LWP
Sbjct: 768 ALKASSSAGNLGVLIPVIAVLTKRLPPIKEAKPRLQKLFRDFWLYSVVMGFAVEGSGLWP 827
Query: 3978 EEWYNAVCETATKTPVLI--ATENLRSELIDNAAIRSDSISPQELQEMRNTVLAELSHQA 3805
EWY VCE ATK+P+L + E LRSEL N+A+++D+++ EL ++R+T++ L
Sbjct: 828 AEWYEGVCEIATKSPLLTFPSGEPLRSELQYNSALKNDTVTAAELNDLRSTIINLLDPPP 887
Query: 3804 EAVPLINRFDFANCTYLLSVHRMETMRLIHANHVDAFSSFFKYIEDKTMRKDKSGLWTCM 3625
E L+N+ DFA TYLLSV+R+E MR++++ D F F+Y ED+ ++KDKSG+ C+
Sbjct: 888 EVAALVNKLDFAMSTYLLSVYRLEYMRMLYSLDSDRFQVMFRYFEDRAIQKDKSGMMQCV 947
Query: 3624 LAAAPRIFLEWCEKMMKRRDNDEPTEEALVWHAQFLLFKFNHHLREVRKVADACLSQLVK 3445
+A + ++F E +MM + + EE L HAQFLL FNH + +R+VAD LS L +
Sbjct: 948 VAVSDKVF-EVFLQMMVDKPKTKAHEEELERHAQFLLVNFNHIHKRIRRVADKYLSGLAE 1006
Query: 3444 AFPYLLWNTKVLTTILRLLQELEDNLQKDPTCREPQFTIEGFGGWTIQLQDSIEGRRSVV 3265
FP+LLW+ +VL T+L +LQ L +L D +P + I I + D+ E R S+V
Sbjct: 1007 TFPHLLWSGRVLRTMLDILQTLSLSLSADIHKDQPYYDIPDTPH-RITVPDTYEARESIV 1065
Query: 3264 KDFSMRVKQILKEALRWA----------------------------------PASTHSN- 3190
KDF+ R +ILKEA++WA P+S+ S+
Sbjct: 1066 KDFAARCGEILKEAMKWAPSVTKSHLQVPPFKASKDRKCHVNTEVMSKTSPHPSSSSSSS 1125
Query: 3189 ---LLEYVSKF-----GSERDAAMQLAIDATSEGSGKS---------------------- 3100
EY++K G + + +A ++ +G +
Sbjct: 1126 SVPFQEYLNKHQNWVSGLSQHTGLAMATESILHFAGYNRQSTTLGSTQLTERPACVKKDY 1185
Query: 3099 GSYLTSLYKRSNYLGQVKGMLATTLSGDIDQVTAENQLIDRLEKDFQRACKSGKDMEMEQ 2920
+++ SL R+ Y G+V GM+ + V + L + K A SG+ +
Sbjct: 1186 SNFMASLNLRNRYAGEVSGMIHFAQA-----VRGLSDLSQLMIKQMGEALDSGQPEAFTE 1240
Query: 2919 AVLLLTALFVSLRSLNERILSLLVRTPLLNFTESTVSLCTMAWNWLLSARPEAHSLFLHE 2740
A+ L AL +S + + ++L L +PL FT + W WLL+AR F+ E
Sbjct: 1241 AMFKLAALLISSKECDPQLLHHLCWSPLKMFTAHGMETAIACWEWLLAARVGVEVAFMRE 1300
Query: 2739 QARAFADSSRFGLGLFEKEVVGGSPLCQKLERPPPSA--NFRPHREWIEFIGERCDVASY 2566
A A+ + GLF V PL E P + PH W+EF+ +R ++A Y
Sbjct: 1301 MAGAWQMTVELKKGLFSDTQVEADPLAASEESQPIPCPPDITPHHIWLEFLVQRFEIAKY 1360
Query: 2565 SSREQLDVLEMMFSQTLSAHIGTGHLHGSTACSNPASLAGPSRKETINQVTRGIEAVGVR 2386
SS +Q+++ + ++LS ++G + + + R + A+G R
Sbjct: 1361 SSADQVEIFGTLLQRSLSLNVGGVN----------------------SSLNRHVAAIGPR 1398
Query: 2385 FRLLSCVLGMVQQDACLLRPTNVLIRQRVYSCAFHYFTIAPQGPTQPEERLREDIRLLTR 2206
FRLL+ L ++ D ++R+++YS AF YF+ AP+ PTQ ++ LREDI ++ R
Sbjct: 1399 FRLLTLGLALLHSDVLTNATVRNVLREKIYSTAFDYFSGAPKFPTQGDKNLREDISIMIR 1458
Query: 2205 FFEHLKNDKHYMQKEALAKTDKNLVMSSTMSQMQTNFEKSLLISXXXXXXXXXXXXXTSL 2026
F+ + +DK Y+ L D +++S M +S + S
Sbjct: 1459 FYASILSDKKYLAACHLVPPDNQDPSLNSLSVMNAADLRSNMDSSSRSQQG--------- 1509
Query: 2025 MLPPSTNYANTLTLSSQKSMAATSASIRSGKSIETKLSIEEDRRIKTWMKQRNMLMLLVA 1846
+ NT LSS ++AS +SG S K S + K +MK+R +L+ L+A
Sbjct: 1510 ----GQGWINTYPLSS----GVSTASKKSGTS---KKSNRGTQLHKYYMKRRTLLLALLA 1558
Query: 1845 NEIERLSAWLHPLALAQEDCALDSEEFLRGAFTQAKATGGEKNIWREQAQLAWDISPELA 1666
+EIERL W +PL+ + +++ A ++K + W++ LAWDISP LA
Sbjct: 1559 SEIERLMTWYNPLSTQELAISMEQSVETSIANWRSKYISLTEKQWKDNVNLAWDISPYLA 1618
Query: 1665 IQLPSRFRGSPELVKYVDVLVRGQPEPVAHIPEALPLFLGNGSTVFETSDMSHVLTWARC 1486
IQLP+RF+ +V V LVR P V+ +PEA+ + + ++ ++SH+L WA
Sbjct: 1619 IQLPTRFKNDA-IVAEVTRLVRMDPGAVSDVPEAVKFLVTWHTIDADSPELSHILCWAPA 1677
Query: 1485 SPVMALSLLTPRIYPMHPISMQYAVRVLRSYSADELLLYIPQIVQAVRYDTMGYISELII 1306
P LS + +YP HP++ QY V+VLRS+ D +L YIPQIVQA+RYD MGY+ E I+
Sbjct: 1678 DPPTGLSYFSS-MYPPHPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYDKMGYVREYIL 1736
Query: 1305 WLAGHSQLLSHQLIWNMQTNMFTDEESKVKDPVLFEALNDIMQKILSQLEGAARRFHEAE 1126
W A SQLL+HQ IWNM+TN+F DEE KDP + + L ++++I S L G A+ F++ E
Sbjct: 1737 WAAQTSQLLAHQFIWNMKTNIFVDEEGHHKDPDIGDLLEQMVEEITSSLSGPAKDFYQRE 1796
Query: 1125 FKLFHQLTAISGTIKPFPKGDARKKACLKALADVKIETITYLPSNPEAVLLDLDYSSGTP 946
F F+++T +S IKP PKG+ RK+ACLKAL+D+K++ YLPSNPEAV+LD+DY S TP
Sbjct: 1797 FDFFNKITNVSAIIKPVPKGEERKRACLKALSDIKVQQGCYLPSNPEAVVLDIDYKSRTP 1856
Query: 945 MQSAAKAPFLARFRVKRCGVRELEHIGLQAQSEHGGKTTEADLEELKKVQDSRVCWQAAI 766
MQSAAKAP+LA+F+VKRCGV ELE GL+ S+ +E SRVCWQAAI
Sbjct: 1857 MQSAAKAPYLAKFKVKRCGVSELEREGLRCASD--------STDEQNSDGSSRVCWQAAI 1908
Query: 765 FKVGDDVRXXXXXXXXXXXM------------------------------KNVWAGLGLP 676
FKVGDD R KN++ +GL
Sbjct: 1909 FKVGDDCRQVETTAAGVTAAMFEDRKLTVFSAVTLVSLQDMLALQIIGLFKNIFQLVGLD 1968
Query: 675 VRVFPYRVVATSPGCGVIECVPNSKSRDQLGRQTDFGLYEYFKTQYGDESSETFQEARRN 496
+ VFPYRVVAT+PGCGVIEC+P+ KSRDQLGRQTDFG+Y+YF+ QYGDES+ FQ+AR N
Sbjct: 1969 LFVFPYRVVATAPGCGVIECIPDCKSRDQLGRQTDFGMYDYFRNQYGDESTLAFQKARYN 2028
Query: 495 FVRSMAAYSVFSFLLQIKDRHNGNIMIDLDGHIIHIDFGFMFESSPGGNLGFEPDFKLSE 316
F+RSMAAYS+ FLLQIKDRHNGNIM+D GH+IHIDFGFMFESSPGGNLG+EPD KL++
Sbjct: 2029 FIRSMAAYSLLLFLLQIKDRHNGNIMLDSKGHLIHIDFGFMFESSPGGNLGWEPDIKLTD 2088
Query: 315 EMVAIMGGKMEAAPFRQFASLCVHAYLAVR------------------------PYHKSF 208
EMV IMGGKMEA PF+ F +CV YLAVR PY +
Sbjct: 2089 EMVMIMGGKMEATPFKWFMEMCVRGYLAVRYENMLRGGEAVTIDRSFFFALNCSPYMDAV 2148
Query: 207 VSLVSLMLDTHLPCFRGKTINQLRARFAPEMNEKDAAKYMYSVITNCFLNIRSKMYDQLQ 28
VSLV+LMLDT LPCFRG+TI L+ RF P+M+EK+AA ++ VI +CFL+ RSK YD LQ
Sbjct: 2149 VSLVTLMLDTGLPCFRGQTIKLLKGRFNPQMSEKEAAAFIIKVIQSCFLSSRSKTYDMLQ 2208
Query: 27 YFQNEIPY 4
Y+QN+IPY
Sbjct: 2209 YYQNQIPY 2216
Score = 48.1 bits (113), Expect = 0.003
Identities = 26/71 (36%), Positives = 40/71 (55%), Gaps = 1/71 (1%)
Frame = -1
Query: 6117 QHADELVPMLLRALIALPHMKWIDDGLLNKS-DKIPIQEQFSFCFNTSLSDLAAHLPRFR 5941
QH D +VP LL L LP ++WI++ +K +K+P+ E F+F T LSD+A R
Sbjct: 68 QHKDVIVPYLLGLLKGLPKVQWIEESSEHKGREKLPVAENFTFSLVTLLSDVAQRDETLR 127
Query: 5940 QQIVSAQADAL 5908
+I+ D +
Sbjct: 128 GKILETIMDIM 138
>gi|23397467|ref|NP_570014.2| CG10260-PB [Drosophila melanogaster]
gi|22831588|gb|AAF45800.2| CG10260-PB [Drosophila melanogaster]
Length = 2178
Score = 1147 bits (2967), Expect = 0.0
Identities = 744/2174 (34%), Positives = 1155/2174 (52%), Gaps = 122/2174 (5%)
Frame = -1
Query: 6159 SLIAIANYLLHSHGQHADELVPMLLRALIALPHMKWIDDGLLNKSDK--IPIQEQFSFCF 5986
++IA+ Y L QH ++VP LLR LP WIDD NK ++ IP E+FSFC
Sbjct: 102 AVIALGIYFLEGGCQHEGQIVPYLLRLAKCLPKAVWIDDARSNKVERVRIPSAEKFSFCL 161
Query: 5985 NTSLSDLAAHLPRFRQQIVSAQADALACAVSSIYDVLEDQESLEHNYSHVIKLMCYALGL 5806
NT LSD+AA P R++I+ Q + L+ A+++I D S + GL
Sbjct: 162 NTLLSDIAAKCPDSREEIILNQVETLS-ALANIVKSSRDSSSAPPPIILCKATVPLLFGL 220
Query: 5805 LRSIGRFSADYDTPLISLIFP---LPVDETKKCKGAGGADIKHRISSDEFTFDTSCDASS 5635
RS+GR++++ D PL+ IFP LP+ + G G + F+ A+
Sbjct: 221 ARSMGRYASN-DPPLLCRIFPPELLPIQKGGGRDGTGSSSSASGTCGGSFSSSERLAATH 279
Query: 5634 SDPLLLTDSKSSRLIRMYN------------------------------------KLGAS 5563
++ S S L + N + G+S
Sbjct: 280 HFRPIIPRSMSGSLAQAQNASYDDGRQRCAGGKPSKPSLHSYFSVPYDPRTHFFTRYGSS 339
Query: 5562 FLLNNYTGGLKLTMSS----------------EDLEKLFDSVQRLMDSKFLESLDXXXXX 5431
F N +++ S + L+ +F ++L+ LE LD
Sbjct: 340 F---NQFPNMRVCESPTKGGPRPLYRVPPFPIQHLQTIFAVSKKLLTKDTLEHLDEQASD 396
Query: 5430 XXXXXXGVKRNPYKSMSEITNLCCLTLLKDVLGPYSVKNSDKNQENCGNSLQEASPSSPI 5251
+K YKS SE NL +TLL+++L + + +P +
Sbjct: 397 IFSLHQ-IKGYCYKSFSETLNLVLVTLLRELLQ---------------HQVDLPTPFTKD 440
Query: 5250 SEKFAKEISIFSKTALSKLDAXXXXXXXXXXXXXXXXXSRQKLNIQSATVCLQLXXXXXX 5071
++F K + + +T L + ++ K+N+ + C+ L
Sbjct: 441 VQEFVKRLFLNGQTELQ--NKQQDQERERREENGIAVVNKYKVNVMANAACVDLLVWAIR 498
Query: 5070 XXXXXXXICTEIIVRLFANQTQKTIISQLPLYLKAISSMATLAEKFPAVATTAVIQNLQR 4891
+C + +L + K ++ +PL + + + LA KFP +A T+ I L+
Sbjct: 499 DETEADKLCGRLSQKLNLELSHKIVMDHMPLLMVCLEGLGKLAHKFPNIAGTS-ISYLRD 557
Query: 4890 FLLEPAPMLTKLASDS--TLERGKSAGDV------IQHSKSSNNLIDAITKRK------- 4756
FL+ P+P+L KL + +L + K ++ +QHS S ++ +K
Sbjct: 558 FLVAPSPILGKLHDHAMQSLAQQKKEKELTPFKIAVQHSDSRTAVVIYGDNQKPPGSGTG 617
Query: 4755 ----LSLDALRNSAIKAICRALKSSIRMESDSVQQCLAGLSTKLFVCSNANN------FV 4606
+ ++LR++AI+ + AL+++ ++ V +A +S +LF + +
Sbjct: 618 RSGHAAFESLRDAAIENLSIALRAAHTLDQFCVPALVANVSNRLFTAEKSGSESQGECHK 677
Query: 4605 VSLVCENAIQTLGGIGVGLVDSTAVEVPEMVVQIYLQRFANPPSQLDVTMIRCLAEMWIA 4426
+LV N I LG + V L D++ + + ++Q ++QRF PS+ + ++ L M I+
Sbjct: 678 SNLVSLNIIVMLGHVAVALKDTS--KTTQNILQFFIQRFCKVPSEQNALIVDQLGCMIIS 735
Query: 4425 GARS-IYENVWKLFTQICIESSNRVYSQGNNESNDQRYTHVSLAVDVAMSRMAAGVANED 4249
+ +++ + K+F+++ ++S++ Y+ ++ + +++ HVS AV A+ +AA + +
Sbjct: 736 QCETHVFDEIMKMFSRVTVQSASLAYT--SDPEHRKQFHHVSDAVVNALGNIAANIQGDA 793
Query: 4248 DKMTXXXXXXXXXXXLGIEGRRVGEXXXXXXXXXXXSAGNLGVLMPKIASLLRRMQPISE 4069
+ + +G++G R + AGNLG+L+P IA L+RR+ PI
Sbjct: 794 EMLELLGKLLELFVQIGLDGERSYDNTPGAQKASSR-AGNLGMLIPVIAVLVRRLPPIKN 852
Query: 4068 PTTKLRSLFRDFWFYCTVLGFDVESSSLWPEEWYNAVCETATKTPVLIATENLRSELID- 3892
P +L LF+DFW YC V+GF ++ LWP +WY V + A K+P+LI+ +S++ +
Sbjct: 853 PRQRLHKLFKDFWAYCVVMGFT--NARLWPADWYQGVQQIAAKSPLLISQTAHKSDMREL 910
Query: 3891 --NAAIRSDSISPQELQEMRNTVLAELSHQAEAVPL-INRFDFANCTYLLSVHRMETMRL 3721
AI+SDS++ E+R+ +L L H ++ V IN+ FA CTYLLSV+ +E +R+
Sbjct: 911 NYTLAIKSDSVN-----ELRSQILVLLEHSSDNVATAINKLSFAQCTYLLSVYWLEMLRV 965
Query: 3720 IHANHVDAFSSFFKYIEDKTMRKDKSGLWTCMLAAAPRIFLEWCEKMMKRRDNDEPTEEA 3541
+A+ + Y+ D +++DK+G+W C+ A ++F ++ + +DE E+
Sbjct: 966 ENADE-PSLEPIMSYLCDTALQRDKTGIWQCVKCVADQVFEKFRNVLYA---HDEIREKV 1021
Query: 3540 LVWHAQFLLFKFNHHLREVRKVADACLSQLVKAFPYLLWNTKVLTTILRLLQELEDNLQK 3361
L A LL FNH + ++ VAD LS LV FP+LLWN +VL +L +LQ L +L
Sbjct: 1022 LESQATLLLVYFNHIHKPIQMVADQYLSFLVDRFPHLLWNRRVLWCMLDILQLLAYSLSL 1081
Query: 3360 DPTCREPQFTIEGFGGWTIQLQDSIEGRRSVVKDFSMRVKQILKEALRWAPASTHSNLLE 3181
DP P + +T+QL DS+ R +KDF+ R + I+ EA++WAP ST S+L E
Sbjct: 1082 DPNEETPTLRVVSTP-YTLQLMDSLPARELRLKDFADRCQGIVNEAMKWAPRSTRSHLQE 1140
Query: 3180 YVSKFGSE---RDAAMQLAIDATSEGSGK---------------SGSYLTSLYKRSNYLG 3055
Y ++ + + + LA D+ S + + +++ L RS Y G
Sbjct: 1141 YPNQIPTPVLAHHSGLALAFDSVVSSSAQHTGTMSKRPSCVNSDTPRFVSVLCLRSKYAG 1200
Query: 3054 QVKGMLATTLSGDIDQVTAENQLIDRLEKDFQRACKSGKDMEMEQAVLLLTALFVSLRSL 2875
++ G+L+ D + L DRL D AC D A+ TA + +
Sbjct: 1201 EISGLLSVLSEKD------KAGLADRLVSDVWEACAEKSDARHRGALWRATAYLIICSEI 1254
Query: 2874 NERILSLLVRTPLLNFTESTVSLCTMAWNWLLSARPEAHSLFLHEQARAFADSSRFGLGL 2695
+ ++L + + L FTES + W W+L+AR + F+ E A+ + +GL
Sbjct: 1255 SRKLLHAVASSQLELFTESAMETAVECWQWVLTARQDLELCFIQEMVSAWQTTFEKRMGL 1314
Query: 2694 FEKEVVGGSPL-----CQKLERPPPSANFRPHREWIEFIGERCDVASYSSREQLDVLEMM 2530
F E PL C+ + +P A PH W++ + E D A Y +R+++++ ++
Sbjct: 1315 FAWETEVTHPLAAYEGCKLVSKPILIA---PHLIWLQLLSEMVDTAKYCNRDKVEMFCLL 1371
Query: 2529 FSQTLSAHIGTGHLHGSTACSNPASLAGPSRKETINQVTRGIEAVGVRFRLLSCVLGMVQ 2350
+ L P K + + R + VG RF+LL C L ++Q
Sbjct: 1372 LHRCL-----------------------PVLKSS--KQNRQVSTVGCRFKLLQCGLSLLQ 1406
Query: 2349 QDACLLRPTNVLIRQRVYSCAFHYFTIAPQGPTQPEERLREDIRLLTRFFEHLKNDKHYM 2170
+ + ++R+R+YS A YF P P Q E+L EDI +L +F++ ++++K ++
Sbjct: 1407 GNTIPKSLSRNILRERIYSNALDYFCGPPTCPNQSREQLLEDIMILLKFWQTMRSEKKHL 1466
Query: 2169 QKEALAKTD-KNLVMSST-MSQMQTNFEKSLLISXXXXXXXXXXXXXTSLMLP------- 2017
+ D N +SST M ++ N E + LIS S
Sbjct: 1467 VTSEVGDYDLTNASVSSTQMLAVRNNPETASLISGGGLVNDYTRSMSASGNAVGMGMGVA 1526
Query: 2016 ---PSTNYANTLTLSSQKSMAATSASIRSGKSIETKLSIEEDRRIKTWMKQRNMLMLLVA 1846
S+ + NT+ S+ ++ S RS +S +L ++D K +MK+RN+++ L+A
Sbjct: 1527 GGGSSSGWYNTIPHST------STLSKRSNRS--KRLQYQKDSYDKDYMKKRNLILELLA 1578
Query: 1845 NEIERLSAWLHPLALAQEDCALDSEEFLRGAFTQAKATGGEKNIWREQAQLAWDISPELA 1666
E+E L W +P +L D + EE + T+ + + +WR+ A+LAW +P LA
Sbjct: 1579 VELEFLITWYNPNSLP--DLIVPGEEQI----TEWRNRPYKSTVWRDYARLAWCYNPALA 1632
Query: 1665 IQLPSRFRGSPELVKYVDVLVRGQPEPVAHIPEALPLFLGNGSTVFETSDMSHVLTWARC 1486
+ LP R + + + + V LV P V HIPEAL + + E+ D+ ++L+W+
Sbjct: 1633 VFLPQRIKNAEIIDEEVSRLVCSDPIAVCHIPEALKYLCTTKNLLQESPDLVYILSWSPV 1692
Query: 1485 SPVMALSLLTPRIYPMHPISMQYAVRVLRSYSADELLLYIPQIVQAVRYDTMGYISELII 1306
+P+ AL+ + R YP HP++ QYAV+ L SY A+ +L YIPQ+VQA+R+DTMGY+ E I
Sbjct: 1693 TPIQALAYFS-RQYPSHPLTAQYAVKTLSSYPAESVLPYIPQLVQALRHDTMGYVVEFIK 1751
Query: 1305 WLAGHSQLLSHQLIWNMQTNMFTDEESKVKDPVLFEALNDIMQKILSQLEGAARRFHEAE 1126
++ SQ+++HQLIWNMQTNM+ DE+ + KDP L+EAL+ + Q I++ GAA+RF+E E
Sbjct: 1752 NISRRSQIVAHQLIWNMQTNMYMDEDQQHKDPNLYEALDQLSQSIIASFSGAAKRFYERE 1811
Query: 1125 FKLFHQLTAISGTIKPFPKGDARKKACLKALADVKIETITYLPSNPEAVLLDLDYSSGTP 946
F F ++TA+SG I+ F KG RK ACL AL+ +K++ YLPSNPEA++LD+DYSSGTP
Sbjct: 1812 FDFFGKITAVSGEIRSFAKGIERKNACLAALSRIKVQGGCYLPSNPEAMVLDIDYSSGTP 1871
Query: 945 MQSAAKAPFLARFRVKRCGVRELEHIGLQAQSEHGGKTTEADLEELKKVQDSRVCWQAAI 766
MQSAAKAP+LARFRV RCG+ ELE +A ++ D + V+ WQAAI
Sbjct: 1872 MQSAAKAPYLARFRVYRCGITELE---TRAMEVSNNPNSQEDAKMTLGVES----WQAAI 1924
Query: 765 FKVGDDVRXXXXXXXXXXXMKNVWAGLGLPVRVFPYRVVATSPGCGVIECVPNSKSRDQL 586
FKVGDDVR KN++ +GL + +FPYRVVAT+PGCGVIECVPN+KSRDQL
Sbjct: 1925 FKVGDDVRQDMLALQVITIFKNIFQQVGLDLFLFPYRVVATAPGCGVIECVPNAKSRDQL 1984
Query: 585 GRQTDFGLYEYFKTQYGDESSETFQEARRNFVRSMAAYSVFSFLLQIKDRHNGNIMIDLD 406
GRQTD GL EYF+ QYGDESS+ FQ AR NFV+SMAAYS+ +LLQIKDRHNGNIMID D
Sbjct: 1985 GRQTDSGLSEYFQHQYGDESSKEFQAARANFVKSMAAYSLIGYLLQIKDRHNGNIMIDKD 2044
Query: 405 GHIIHIDFGFMFESSPGGNLGFEPDFKLSEEMVAIMGGKMEAAPFRQFASLCVHAYLAVR 226
GHIIHIDFGFMFESSPGGN+GFEPD KL++EMV IMGGKM++ F+ F LCV A+LAVR
Sbjct: 2045 GHIIHIDFGFMFESSPGGNIGFEPDMKLTDEMVMIMGGKMDSPAFKWFCELCVQAFLAVR 2104
Query: 225 PYHKSFVSLVSLMLDTHLPCFRGKTINQLRARFAPEMNEKDAAKYMYSVITNCFLNIRSK 46
PY + VSLVSLMLDT LPCFRG+TIN L+ RF N K+AA +M +VI N + N R++
Sbjct: 2105 PYQDAIVSLVSLMLDTGLPCFRGQTINLLKQRFVATKNNKEAAAHMLAVIRNSYQNFRTR 2164
Query: 45 MYDQLQYFQNEIPY 4
YD +QY+QN+IPY
Sbjct: 2165 TYDMIQYYQNQIPY 2178
>gi|2136690|pir||S65741 1-phosphatidylinositol 4-kinase (EC 2.7.1.67)
type 3 - bovine (fragment)
Length = 1466
Score = 1127 bits (2915), Expect = 0.0
Identities = 642/1538 (41%), Positives = 901/1538 (57%), Gaps = 35/1538 (2%)
Frame = -1
Query: 4512 VQIYLQRFANPPSQLDVTMIRCLAEMWIAGARSIYENVWKLFTQICIESSNRVYSQGNNE 4333
VQI Q+F PPS LDV +I L + I G + IY+ VW LF QI +++S+ VYS +
Sbjct: 2 VQILQQKFCQPPSPLDVLIIDQLGCLVITGNQYIYQEVWNLFQQISVKASSVVYS-ATKD 60
Query: 4332 SNDQRYTHVSLAVDVAMSRMAAGVANEDDKMTXXXXXXXXXXXLGIEGRRVGEXXXXX-- 4159
D Y H SLAV A++ +A + +E LG+EG+R E
Sbjct: 61 YKDHGYRHCSLAVINALANIAGNIQDEHLVDELLMNLLELFVQLGLEGKRASERASEKGP 120
Query: 4158 XXXXXXSAGNLGVLMPKIASLLRRMQPISEPTTKLRSLFRDFWFYCTVLGFDVESSSLWP 3979
SAGNLGVL+P IA L RR+ PI EP +L+ L RDF Y ++GF VE S LWP
Sbjct: 121 ALKASSSAGNLGVLIPVIAVLTRRLPPIKEPKPRLQKLLRDFGLYSVLMGFAVEGSGLWP 180
Query: 3978 EEWYNAVCETATKTPVLI--ATENLRSELIDNAAIRSDSISPQELQEMRNTVLAELSHQA 3805
EEWY VC+ ATK+P+L + E LRS L N+A+++D+++P EL E+R+T++ L
Sbjct: 181 EEWYEGVCDIATKSPLLTFPSKEPLRSVLQYNSAMKNDTVTPAELSELRSTIVNLLDPAP 240
Query: 3804 EAVPLINRFDFANCTYLLSVHRMETMRLIHANHVDAFSSFFKYIEDKTMRKDKSGLWTCM 3625
E LI + DFA TYLLSV+R+E MR++ ++ F F Y EDK ++KDKSG+ C+
Sbjct: 241 EVSALIGKLDFAMSTYLLSVYRLEYMRVLRSSDPARFQVMFCYFEDKAIQKDKSGMMQCV 300
Query: 3624 LAAAPRIFLEWCEKMMKRRDNDEPTEEALVWHAQFLLFKFNHHLREVRKVADACLSQLVK 3445
+A A ++F + M ++ E EE L HAQFLL FNH + +R+VAD LS LV
Sbjct: 301 IAVADKVFAAFLNMMAEKAKTKE-NEEELERHAQFLLVSFNHVHKRIRRVADKYLSGLVD 359
Query: 3444 AFPYLLWNTKVLTTILRLLQELEDNLQKDPTCREPQFTIEGFGGWTIQLQDSIEGRRSVV 3265
FP+LLW+ VL T+L +LQ L +L D +P + I + I + D+ E R S+V
Sbjct: 360 KFPHLLWSGTVLETMLDILQTLSLSLSADIHKDQPYYDIPDVP-YRITVPDTYEARESIV 418
Query: 3264 KDFSMRVKQILKEALRWAPASTHSNLLEYVSKF-----GSERDAAMQLAIDATSEGSGKS 3100
KDF+ R IL+EA++WAP T S+L EY+SK G + + +A ++ +G +
Sbjct: 419 KDFAARCGMILQEAMKWAPTVTKSHLQEYLSKHQNWVSGLSQHTGLAMATESVLHYAGYN 478
Query: 3099 ----------------------GSYLTSLYKRSNYLGQVKGMLATTLSGDIDQVTAENQL 2986
+++ SL R+ Y G+V GM+ + D + L
Sbjct: 479 KQSTSLGATQLTERRACVKKDYSNFMASLNLRNRYAGEVYGMIRFS-----DATGHTSDL 533
Query: 2985 IDRLEKDFQRACKSGKDMEMEQAVLLLTALFVSLRSLNERILSLLVRTPLLNFTESTVSL 2806
+ ++ + A +G + QA+ LTA+ +S R + ++L L PL F E +
Sbjct: 534 NKMMVQELKAALGAGDAQQYTQAMFKLTAMLISSRDCDPQLLHHLCWGPLQMFNEHGMET 593
Query: 2805 CTMAWNWLLSARPEAHSLFLHEQARAFADSSRFGLGLFEKEVVGGSPLC-QKLERPPPSA 2629
W WLL+ + F+ E A A+ + GLF E+ PL + +P P A
Sbjct: 594 ALACWEWLLAGKNGVEVPFMREMAGAWQMTVEQKFGLFSAEMKEADPLAASEASQPKPCA 653
Query: 2628 -NFRPHREWIEFIGERCDVASYSSREQLDVLEMMFSQTLSAHIGTGHLHGSTACSNPASL 2452
PH WI+F+ +R ++A Y S +Q+++ + ++LS IG
Sbjct: 654 PEVTPHYIWIDFLVQRFEIAKYCSSDQVEIFCSLLQRSLSLSIGG--------------- 698
Query: 2451 AGPSRKETINQVTRGIEAVGVRFRLLSCVLGMVQQDACLLRPTNVLIRQRVYSCAFHYFT 2272
T + R + A+G RF+LL+ L ++ D ++R+++YS AF YF+
Sbjct: 699 -------TAGSMNRHVAAIGPRFKLLTLGLSLLHADVLPNATIRNVLREKIYSTAFDYFS 751
Query: 2271 IAPQGPTQPEERLREDIRLLTRFFEHLKNDKHYMQKEALAKTDKNLVMSSTMSQMQTNFE 2092
P+ PTQ E+RLREDI ++ +F+ + +DK Y+ L D S+ + + +
Sbjct: 752 CPPRFPTQGEKRLREDISVMIKFWTAMFSDKKYLTASQLVPPDNQDTRSNLDIAVGSRQQ 811
Query: 2091 KSLLISXXXXXXXXXXXXXTSLMLPPSTNYANTLTLSSQKSMAATSASIRSGKSIETKLS 1912
+ + NT LSS S + S +SG S +T
Sbjct: 812 AT-------------------------QGWINTYPLSSGMS----TISKKSGMSKKTNRG 842
Query: 1911 IEEDRRIKTWMKQRNMLMLLVANEIERLSAWLHPLALAQEDCALDSEEFLRGAFTQAKAT 1732
+ K +MK+R +L+ L+A EIERL W +PL+ + + LD A ++K
Sbjct: 843 SQLH---KYYMKRRTLLLSLLATEIERLITWYNPLSAPELE--LDQAGESSVANWRSKYI 897
Query: 1731 GGEKNIWREQAQLAWDISPELAIQLPSRFRGSPELVKYVDVLVRGQPEPVAHIPEALPLF 1552
+ W++ LAW ISP LA+QLP+RF+ + + V LVR P V+ +PEA+
Sbjct: 898 SLSEKQWKDNVNLAWSISPHLAVQLPARFKNTEAIGNEVTRLVRLDPGAVSDVPEAIKFL 957
Query: 1551 LGNGSTVFETSDMSHVLTWARCSPVMALSLLTPRIYPMHPISMQYAVRVLRSYSADELLL 1372
+ + + ++SHVL WA P LS + +YP HP++ QY V+VLRS+ D +L
Sbjct: 958 VTWHTIDADAPELSHVLCWAPADPPTGLSYFSS-MYPPHPLTAQYGVKVLRSFPPDAILF 1016
Query: 1371 YIPQIVQAVRYDTMGYISELIIWLAGHSQLLSHQLIWNMQTNMFTDEESKVKDPVLFEAL 1192
YIPQIVQA+RYD MGY+ E I+W A SQLL+HQ IWNM+TN++ DEE KDP + + L
Sbjct: 1017 YIPQIVQALRYDKMGYVREYILWAASQSQLLAHQFIWNMKTNIYVDEEGHQKDPDIGDLL 1076
Query: 1191 NDIMQKILSQLEGAARRFHEAEFKLFHQLTAISGTIKPFPKGDARKKACLKALADVKIET 1012
++++I L G A+ F++ EF F+++T +S IKP+PKGD RKKACL AL++VK++
Sbjct: 1077 EQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPYPKGDERKKACLSALSEVKVQP 1136
Query: 1011 ITYLPSNPEAVLLDLDYSSGTPMQSAAKAPFLARFRVKRCGVRELEHIGLQAQS--EHGG 838
YLPSNPEA++LD+DY SGTPMQSAAKAP+LA+F+VKRCGV ELE GL+ +S E G
Sbjct: 1137 GCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEGLRCRSDPEEEG 1196
Query: 837 KTTEADLEELKKVQDSRVCWQAAIFKVGDDVRXXXXXXXXXXXMKNVWAGLGLPVRVFPY 658
EAD ++ WQAAIFKVG D R KN++ +GL + VFPY
Sbjct: 1197 SMQEAD--------GQKISWQAAIFKVGGDCRQDMLALQIIDLFKNIFQLVGLDLFVFPY 1248
Query: 657 RVVATSPGCGVIECVPNSKSRDQLGRQTDFGLYEYFKTQYGDESSETFQEARRNFVRSMA 478
RVVAT+PGCGVIEC+P+ SRDQLGRQTDFG+Y+YF QYGDES+ FQ+AR NF+RSMA
Sbjct: 1249 RVVATAPGCGVIECIPDCTSRDQLGRQTDFGMYDYFTRQYGDESTLAFQQARYNFIRSMA 1308
Query: 477 AYSVFSFLLQIKDRHNGNIMIDLDGHIIHIDFGFMFESSPGGNLGFEPDFKLSEEMVAIM 298
AYS+ FLLQIKDRHNGNIM+D GH+IHIDFGFMFESSPGGNLG+EPD KL++EMV IM
Sbjct: 1309 AYSLLLFLLQIKDRHNGNIMLDKKGHLIHIDFGFMFESSPGGNLGWEPDIKLTDEMVMIM 1368
Query: 297 GGKMEAAPFRQFASLCVHAYLAVRPYHKSFVSLVSLMLDTHLPCFRGKTINQLRARFAPE 118
GGKMEA PF+ F +CV YLAVRPY + VSLV+LMLDT LPCFRG+TI L+ RF+P
Sbjct: 1369 GGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFRGQTIKLLKHRFSPN 1428
Query: 117 MNEKDAAKYMYSVITNCFLNIRSKMYDQLQYFQNEIPY 4
M E++AA ++ VI +CFL+ RS+ YD +QY+QN+IPY
Sbjct: 1429 MTEREAANFILKVIQSCFLSNRSRTYDMIQYYQNDIPY 1466
>gi|7547268|gb|AAB36289.2| type 3 phosphatidylinositol 4-kinase [Bos
taurus]
Length = 1466
Score = 1126 bits (2912), Expect = 0.0
Identities = 642/1538 (41%), Positives = 901/1538 (57%), Gaps = 35/1538 (2%)
Frame = -1
Query: 4512 VQIYLQRFANPPSQLDVTMIRCLAEMWIAGARSIYENVWKLFTQICIESSNRVYSQGNNE 4333
VQI Q+F PPS LDV +I L + I G + IY+ VW LF QI +++S+ VYS +
Sbjct: 2 VQILQQKFCQPPSPLDVLIIDQLGCLVITGNQYIYQEVWNLFQQISVKASSVVYS-ATKD 60
Query: 4332 SNDQRYTHVSLAVDVAMSRMAAGVANEDDKMTXXXXXXXXXXXLGIEGRRVGEXXXXX-- 4159
D Y H SLAV A++ +A + +E LG+EG+R E
Sbjct: 61 YKDHGYRHCSLAVINALANIAGNIQDEHLVDELLMNLLELFVQLGLEGKRASERASEKGP 120
Query: 4158 XXXXXXSAGNLGVLMPKIASLLRRMQPISEPTTKLRSLFRDFWFYCTVLGFDVESSSLWP 3979
SAGNLGVL+P IA L RR+ PI EP +L+ L RDF Y ++GF VE S LWP
Sbjct: 121 ALKASSSAGNLGVLIPVIAVLTRRLPPIKEPKPRLQKLLRDFGLYSVLMGFAVEGSGLWP 180
Query: 3978 EEWYNAVCETATKTPVLI--ATENLRSELIDNAAIRSDSISPQELQEMRNTVLAELSHQA 3805
EEWY VC+ ATK+P+L + E LRS L N+A+++D+++P EL E+R+T++ L
Sbjct: 181 EEWYEGVCDIATKSPLLTFPSKEPLRSVLQYNSAMKNDTVTPAELSELRSTIVNLLDPAP 240
Query: 3804 EAVPLINRFDFANCTYLLSVHRMETMRLIHANHVDAFSSFFKYIEDKTMRKDKSGLWTCM 3625
E LI + DFA TYLLSV+R+E MR++ ++ F F Y EDK ++KDKSG+ C+
Sbjct: 241 EVSALIGKLDFAMSTYLLSVYRLEYMRVLRSSDPARFQVMFCYFEDKAIQKDKSGMMQCV 300
Query: 3624 LAAAPRIFLEWCEKMMKRRDNDEPTEEALVWHAQFLLFKFNHHLREVRKVADACLSQLVK 3445
+A A ++F + M ++ E EE L HAQFLL FNH + +R+VAD LS LV
Sbjct: 301 IAVADKVFDAFLNMMAEKAKTKE-NEEELERHAQFLLVSFNHVHKRIRRVADKYLSGLVD 359
Query: 3444 AFPYLLWNTKVLTTILRLLQELEDNLQKDPTCREPQFTIEGFGGWTIQLQDSIEGRRSVV 3265
FP+LLW+ VL T+L +LQ L +L D +P + I + I + D+ E R S+V
Sbjct: 360 KFPHLLWSGTVLETMLDILQTLSLSLSADIHKDQPYYDIPDVP-YRITVPDTYEARESIV 418
Query: 3264 KDFSMRVKQILKEALRWAPASTHSNLLEYVSKF-----GSERDAAMQLAIDATSEGSGKS 3100
KDF+ R IL+EA++WAP T S+L EY+SK G + + +A ++ +G +
Sbjct: 419 KDFAARCGMILQEAMKWAPTVTKSHLQEYLSKHQNWVSGLSQHTGLAMATESVLHYAGYN 478
Query: 3099 ----------------------GSYLTSLYKRSNYLGQVKGMLATTLSGDIDQVTAENQL 2986
+++ SL R+ Y G+V GM+ + D + L
Sbjct: 479 KQSTSLGATQLTERRACVKKDYSNFMASLNLRNRYAGEVYGMIRFS-----DATGHTSDL 533
Query: 2985 IDRLEKDFQRACKSGKDMEMEQAVLLLTALFVSLRSLNERILSLLVRTPLLNFTESTVSL 2806
+ ++ + A +G + QA+ LTA+ +S R + ++L L PL F E +
Sbjct: 534 NKMMVQELKAALGAGDAQQYTQAMFKLTAMLISSRDCDPQLLHHLCWGPLQMFNEHGMET 593
Query: 2805 CTMAWNWLLSARPEAHSLFLHEQARAFADSSRFGLGLFEKEVVGGSPLC-QKLERPPPSA 2629
W WLL+ + F+ E A A+ + GLF E+ PL + +P P A
Sbjct: 594 ALACWEWLLAGKNGVEVPFMREMAGAWQMTVEQKFGLFSAEMKEADPLAASEASQPKPCA 653
Query: 2628 -NFRPHREWIEFIGERCDVASYSSREQLDVLEMMFSQTLSAHIGTGHLHGSTACSNPASL 2452
PH WI+F+ +R ++A Y S +Q+++ + ++LS IG
Sbjct: 654 PEVTPHYIWIDFLVQRFEIAKYCSSDQVEIFCSLLQRSLSLSIGG--------------- 698
Query: 2451 AGPSRKETINQVTRGIEAVGVRFRLLSCVLGMVQQDACLLRPTNVLIRQRVYSCAFHYFT 2272
T + R + A+G RF+LL+ L ++ D ++R+++YS AF YF+
Sbjct: 699 -------TAGSMNRHVAAIGPRFKLLTLGLSLLHADVLPNATIRNVLREKIYSTAFDYFS 751
Query: 2271 IAPQGPTQPEERLREDIRLLTRFFEHLKNDKHYMQKEALAKTDKNLVMSSTMSQMQTNFE 2092
P+ PTQ E+RLREDI ++ +F+ + +DK Y+ L D S+ + + +
Sbjct: 752 CPPRFPTQGEKRLREDISVMIKFWTAMFSDKKYLTASQLVPPDNQDTRSNLDIAVGSRQQ 811
Query: 2091 KSLLISXXXXXXXXXXXXXTSLMLPPSTNYANTLTLSSQKSMAATSASIRSGKSIETKLS 1912
+ + NT LSS S + S +SG S +T
Sbjct: 812 AT-------------------------QGWINTYPLSSGMS----TISKKSGMSKKTNRG 842
Query: 1911 IEEDRRIKTWMKQRNMLMLLVANEIERLSAWLHPLALAQEDCALDSEEFLRGAFTQAKAT 1732
+ K +MK+R +L+ L+A EIERL W +PL+ + + LD A ++K
Sbjct: 843 SQLH---KYYMKRRTLLLSLLATEIERLITWYNPLSAPELE--LDQAGESSVANWRSKYI 897
Query: 1731 GGEKNIWREQAQLAWDISPELAIQLPSRFRGSPELVKYVDVLVRGQPEPVAHIPEALPLF 1552
+ W++ LAW ISP LA+QLP+RF+ + + V LVR P V+ +PEA+
Sbjct: 898 SLSEKQWKDNVNLAWSISPHLAVQLPARFKNTEAIGNEVTRLVRLDPGAVSDVPEAIKFL 957
Query: 1551 LGNGSTVFETSDMSHVLTWARCSPVMALSLLTPRIYPMHPISMQYAVRVLRSYSADELLL 1372
+ + + ++SHVL WA P LS + +YP HP++ QY V+VLRS+ D +L
Sbjct: 958 VTWHTIDADAPELSHVLCWAPADPPTGLSYFSS-MYPPHPLTAQYGVKVLRSFPPDAILF 1016
Query: 1371 YIPQIVQAVRYDTMGYISELIIWLAGHSQLLSHQLIWNMQTNMFTDEESKVKDPVLFEAL 1192
YIPQIVQA+RYD MGY+ E I+W A SQLL+HQ IWNM+TN++ DEE KDP + + L
Sbjct: 1017 YIPQIVQALRYDKMGYVREYILWAASQSQLLAHQFIWNMKTNIYVDEEGHQKDPDIGDLL 1076
Query: 1191 NDIMQKILSQLEGAARRFHEAEFKLFHQLTAISGTIKPFPKGDARKKACLKALADVKIET 1012
++++I L G A+ F++ EF F+++T +S IKP+PKGD RKKACL AL++VK++
Sbjct: 1077 EQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPYPKGDERKKACLSALSEVKVQP 1136
Query: 1011 ITYLPSNPEAVLLDLDYSSGTPMQSAAKAPFLARFRVKRCGVRELEHIGLQAQS--EHGG 838
YLPSNPEA++LD+DY SGTPMQSAAKAP+LA+F+VKRCGV ELE GL+ +S E G
Sbjct: 1137 GCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEGLRCRSDPEEEG 1196
Query: 837 KTTEADLEELKKVQDSRVCWQAAIFKVGDDVRXXXXXXXXXXXMKNVWAGLGLPVRVFPY 658
EAD ++ WQAAIFKVG D R KN++ +GL + VFPY
Sbjct: 1197 SMQEAD--------GQKISWQAAIFKVGGDCRQDMLALQIIDLFKNIFQLVGLDLFVFPY 1248
Query: 657 RVVATSPGCGVIECVPNSKSRDQLGRQTDFGLYEYFKTQYGDESSETFQEARRNFVRSMA 478
RVVAT+PGCGVIEC+P+ SRDQLGRQTDFG+Y+YF QYGDES+ FQ+AR NF+RSMA
Sbjct: 1249 RVVATAPGCGVIECIPDCTSRDQLGRQTDFGMYDYFTRQYGDESTLAFQQARYNFIRSMA 1308
Query: 477 AYSVFSFLLQIKDRHNGNIMIDLDGHIIHIDFGFMFESSPGGNLGFEPDFKLSEEMVAIM 298
AYS+ FLLQIKDRHNGNIM+D GH+IHIDFGFMFESSPGGNLG+EPD KL++EMV IM
Sbjct: 1309 AYSLLLFLLQIKDRHNGNIMLDKKGHLIHIDFGFMFESSPGGNLGWEPDIKLTDEMVMIM 1368
Query: 297 GGKMEAAPFRQFASLCVHAYLAVRPYHKSFVSLVSLMLDTHLPCFRGKTINQLRARFAPE 118
GGKMEA PF+ F +CV YLAVRPY + VSLV+LMLDT LPCFRG+TI L+ RF+P
Sbjct: 1369 GGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFRGQTIKLLKHRFSPN 1428
Query: 117 MNEKDAAKYMYSVITNCFLNIRSKMYDQLQYFQNEIPY 4
M E++AA ++ VI +CFL+ RS+ YD +QY+QN+IPY
Sbjct: 1429 MTEREAANFILKVIQSCFLSNRSRTYDMIQYYQNDIPY 1466
>gi|6691825|emb|CAB65858.1| EG:BACR7C10.2 [Drosophila melanogaster]
Length = 2160
Score = 1088 bits (2814), Expect = 0.0
Identities = 675/1902 (35%), Positives = 1049/1902 (54%), Gaps = 65/1902 (3%)
Frame = -1
Query: 5514 EDLEKLFDSVQRLMDSKFLESLDXXXXXXXXXXXGVKRNPYKSMSEITNLCCLTLLKDVL 5335
+ L+ +F ++L+ LE LD +K YKS SE NL +TLL+++L
Sbjct: 351 QHLQTIFAVSKKLLTKDTLEHLDEQASDIFSLHQ-IKGYCYKSFSETLNLVLVTLLRELL 409
Query: 5334 GPYSVKNSDKNQENCGNSLQEASPSSPISEKFAKEISIFSKTALSKLDAXXXXXXXXXXX 5155
+ + +P + ++F K + + +T L +
Sbjct: 410 Q---------------HQVDLPTPFTKDVQEFVKRLFLNGQTELQ--NKQQDQERERREE 452
Query: 5154 XXXXXXSRQKLNIQSATVCLQLXXXXXXXXXXXXXICTEIIVRLFANQTQKTIISQLPLY 4975
++ K+N+ + C+ L +C + +L + K ++ +PL
Sbjct: 453 NGIAVVNKYKVNVMANAACVDLLVWAIRDETEADKLCGRLSQKLNLELSHKIVMDHMPLL 512
Query: 4974 LKAISSMATLAEKFPAVATTAVIQNLQRFLLEPAPMLTKLASDS--TLERGKSAGDV--- 4810
+ + + LA KFP +A T+ I L+ FL+ P+P+L KL + +L + K ++
Sbjct: 513 MVCLEGLGKLAHKFPNIAGTS-ISYLRDFLVAPSPILGKLHDHAMQSLAQQKKEKELTPF 571
Query: 4809 ---IQHSKSSNNLIDAITKRK-----------LSLDALRNSAIKAICRALKSSIRMESDS 4672
+QHS S ++ +K + ++LR++AI+ + AL+++ ++
Sbjct: 572 KIAVQHSDSRTAVVIYGDNQKPPGSGTGRSGHAAFESLRDAAIENLSIALRAAHTLDQFC 631
Query: 4671 VQQCLAGLSTKLFVCSNANN------FVVSLVCENAIQTLGGIGVGLVDSTAVEVPEMVV 4510
V +A +S +LF + + +LV N I LG + V L D++ + + ++
Sbjct: 632 VPALVANVSNRLFTAEKSGSESQGECHKSNLVSLNIIVMLGHVAVALKDTS--KTTQNIL 689
Query: 4509 QIYLQRFANPPSQLDVTMIRCLAEMWIAGARS-IYENVWKLFTQICIESSNRVYSQGNNE 4333
Q ++QRF PS+ + ++ L M I+ + +++ + K+F+++ ++S++ Y+ ++
Sbjct: 690 QFFIQRFCKVPSEQNALIVDQLGCMIISQCETHVFDEIMKMFSRVTVQSASLAYT--SDP 747
Query: 4332 SNDQRYTHVSLAVDVAMSRMAAGVANEDDKMTXXXXXXXXXXXLGIEGRRVGEXXXXXXX 4153
+ +++ HVS AV A+ +AA + + + + +G++G R +
Sbjct: 748 EHRKQFHHVSDAVVNALGNIAANIQGDAEMLELLGKLLELFVQIGLDGERSYDNTPGAQK 807
Query: 4152 XXXXSAGNLGVLMPKIASLLRRMQPISEPTTKLRSLFRDFWFYCTVLGFDVESSSLWPEE 3973
AGNLG+L+P IA L+RR+ PI P +L LF+DFW YC V+GF ++ LWP +
Sbjct: 808 ASSR-AGNLGMLIPVIAVLVRRLPPIKNPRQRLHKLFKDFWAYCVVMGFT--NARLWPAD 864
Query: 3972 WYNAVCETATKTPVLIATENLRSELID---NAAIRSDSISPQELQEMRNTVLAELSHQAE 3802
WY V + A K+P+LI+ +S++ + AI+SDS++ E+R+ +L L H ++
Sbjct: 865 WYQGVQQIAAKSPLLISQTAHKSDMRELNYTLAIKSDSVN-----ELRSQILVLLEHSSD 919
Query: 3801 AVPL-INRFDFANCTYLLSVHRMETMRLIHANHVDAFSSFFKYIEDKTMRKDKSGLWTCM 3625
V IN+ FA CTYLLSV+ +E +R+ +A+ + Y+ D +++DK+G+W C+
Sbjct: 920 NVATAINKLSFAQCTYLLSVYWLEMLRVENADE-PSLEPIMSYLCDTALQRDKTGIWQCV 978
Query: 3624 LAAAPRIFLEWCEKMMKRRDNDEPTEEALVWHAQFLLFKFNHHLREVRKVADACLSQLVK 3445
A ++F ++ + +DE E+ L A LL FNH + ++ VAD LS LV
Sbjct: 979 KCVADQVFEKFRNVLYA---HDEIREKVLESQATLLLVYFNHIHKPIQMVADQYLSFLVD 1035
Query: 3444 AFPYLLWNTKVLTTILRLLQELEDNLQKDPTCREPQFTIEGFGGWTIQLQDSIEGRRSVV 3265
FP+LLWN +VL +L +LQ L +L DP P + +T+QL DS+ R +
Sbjct: 1036 RFPHLLWNRRVLWCMLDILQLLAYSLSLDPNEETPTLRVVSTP-YTLQLMDSLPARELRL 1094
Query: 3264 KDFSMRVKQILKEALRWAPASTHSNLLEYVSKFGSE---RDAAMQLAIDATSEGSGK--- 3103
KDF+ R + I+ EA++WAP ST S+L EY ++ + + + LA D+ S +
Sbjct: 1095 KDFADRCQGIVNEAMKWAPRSTRSHLQEYPNQIPTPVLAHHSGLALAFDSVVSSSAQHTG 1154
Query: 3102 ------------SGSYLTSLYKRSNYLGQVKGMLATTLSGDIDQVTAENQLIDRLEKDFQ 2959
+ +++ L RS Y G++ G+L+ D + L DRL D
Sbjct: 1155 TMSKRPSCVNSDTPRFVSVLCLRSKYAGEISGLLSVLSEKD------KAGLADRLVSDVW 1208
Query: 2958 RACKSGKDMEMEQAVLLLTALFVSLRSLNERILSLLVRTPLLNFTESTVSLCTMAWNWLL 2779
AC D A+ TA + ++ ++L + + L FTES + W W+L
Sbjct: 1209 EACAEKSDARHRGALWRATAYLIICSEISRKLLHAVASSQLELFTESAMETAVECWQWVL 1268
Query: 2778 SARPEAHSLFLHEQARAFADSSRFGLGLFEKEVVGGSPL-----CQKLERPPPSANFRPH 2614
+AR + F+ E A+ + +GLF E PL C+ + +P A PH
Sbjct: 1269 TARQDLELCFIQEMVSAWQTTFEKRMGLFAWETEVTHPLAAYEGCKLVSKPILIA---PH 1325
Query: 2613 REWIEFIGERCDVASYSSREQLDVLEMMFSQTLSAHIGTGHLHGSTACSNPASLAGPSRK 2434
W++ + E D A Y +R+++++ ++ + L P K
Sbjct: 1326 LIWLQLLSEMVDTAKYCNRDKVEMFCLLLHRCL-----------------------PVLK 1362
Query: 2433 ETINQVTRGIEAVGVRFRLLSCVLGMVQQDACLLRPTNVLIRQRVYSCAFHYFTIAPQGP 2254
+ + R + VG RF+LL C L ++Q + + ++R+R+YS A YF P P
Sbjct: 1363 SS--KQNRQVSTVGCRFKLLQCGLSLLQGNTIPKSLSRNILRERIYSNALDYFCGPPTCP 1420
Query: 2253 TQPEERLREDIRLLTRFFEHLKNDKHYMQKEALAKTD-KNLVMSST-MSQMQTNFEKSLL 2080
Q E+L EDI +L +F++ ++++K ++ + D N +SST M ++ N E + L
Sbjct: 1421 NQSREQLLEDIMILLKFWQTMRSEKKHLVTSEVGDYDLTNASVSSTQMLAVRNNPETASL 1480
Query: 2079 ISXXXXXXXXXXXXXTSLMLP----------PSTNYANTLTLSSQKSMAATSASIRSGKS 1930
IS S S+ + NT+ S+ ++ S RS +S
Sbjct: 1481 ISGGGLVNDYTRSMSASGNAVGMGMGVAGGGSSSGWYNTIPHST------STLSKRSNRS 1534
Query: 1929 IETKLSIEEDRRIKTWMKQRNMLMLLVANEIERLSAWLHPLALAQEDCALDSEEFLRGAF 1750
+L ++D K +MK+RN+++ L+A E+E L W +P +L D + EE +
Sbjct: 1535 --KRLQYQKDSYDKDYMKKRNLILELLAVELEFLITWYNPNSLP--DLIVPGEEQI---- 1586
Query: 1749 TQAKATGGEKNIWREQAQLAWDISPELAIQLPSRFRGSPELVKYVDVLVRGQPEPVAHIP 1570
T+ + + +WR+ A+LAW +P LA+ LP R + + + + V LV P V HIP
Sbjct: 1587 TEWRNRPYKSTVWRDYARLAWCYNPALAVFLPQRIKNAEIIDEEVSRLVCSDPIAVCHIP 1646
Query: 1569 EALPLFLGNGSTVFETSDMSHVLTWARCSPVMALSLLTPRIYPMHPISMQYAVRVLRSYS 1390
EAL + + E+ D+ ++L+W+ +P+ AL+ + R YP HP++ QYAV+ L SY
Sbjct: 1647 EALKYLCTTKNLLQESPDLVYILSWSPVTPIQALAYFS-RQYPSHPLTAQYAVKTLSSYP 1705
Query: 1389 ADELLLYIPQIVQAVRYDTMGYISELIIWLAGHSQLLSHQLIWNMQTNMFTDEESKVKDP 1210
A+ +L YIPQ+VQA+R+DTMGY+ E I ++ SQ+++HQLIWNMQTNM+ DE+ + KDP
Sbjct: 1706 AESVLPYIPQLVQALRHDTMGYVVEFIKNISRRSQIVAHQLIWNMQTNMYMDEDQQHKDP 1765
Query: 1209 VLFEALNDIMQKILSQLEGAARRFHEAEFKLFHQLTAISGTIKPFPKGDARKKACLKALA 1030
L+EAL+ + Q I++ GAA+RF+E EF F ++TA+SG I+ F KG RK ACL AL+
Sbjct: 1766 NLYEALDQLSQSIIASFSGAAKRFYEREFDFFGKITAVSGEIRSFAKGIERKNACLAALS 1825
Query: 1029 DVKIETITYLPSNPEAVLLDLDYSSGTPMQSAAKAPFLARFRVKRCGVRELEHIGLQAQS 850
+K++ YLPSNPEA++LD+DYSSGTPMQSAAKAP+LARFRV RCG+ ELE +A
Sbjct: 1826 RIKVQGGCYLPSNPEAMVLDIDYSSGTPMQSAAKAPYLARFRVYRCGITELE---TRAME 1882
Query: 849 EHGGKTTEADLEELKKVQDSRVCWQAAIFKVGDDVRXXXXXXXXXXXMKNVWAGLGLPVR 670
++ D + V+ WQAAIFKVGDDVR KN++ +GL +
Sbjct: 1883 VSNNPNSQEDAKMTLGVES----WQAAIFKVGDDVRQDMLALQVITIFKNIFQQVGLDLF 1938
Query: 669 VFPYRVVATSPGCGVIECVPNSKSRDQLGRQTDFGLYEYFKTQYGDESSETFQEARRNFV 490
+FPYRVVAT+PGCGVIECVPN+KSRDQLGRQTD GL EYF+ QYGDESS+ FQ AR NFV
Sbjct: 1939 LFPYRVVATAPGCGVIECVPNAKSRDQLGRQTDSGLSEYFQHQYGDESSKEFQAARANFV 1998
Query: 489 RSMAAYSVFSFLLQIKDRHNGNIMIDLDGHIIHIDFGFMFESSPGGNLGFEPDFKLSEEM 310
+SMAAYS+ +LLQIKDRHNGNIMID DGHIIHIDFGFMFESSPGGN+GFEPD KL++EM
Sbjct: 1999 KSMAAYSLIGYLLQIKDRHNGNIMIDKDGHIIHIDFGFMFESSPGGNIGFEPDMKLTDEM 2058
Query: 309 VAIMGGKMEAAPFRQFASLCVHAYLAVRPYHKSFVSLVSLMLDTHLPCFRGKTINQLRAR 130
V IMGGKM++ F+ F LCV A+LAVRPY + VSLVSLMLDT LPCFRG+TIN L+ R
Sbjct: 2059 VMIMGGKMDSPAFKWFCELCVQAFLAVRPYQDAIVSLVSLMLDTGLPCFRGQTINLLKQR 2118
Query: 129 FAPEMNEKDAAKYMYSVITNCFLNIRSKMYDQLQYFQNEIPY 4
F N K+AA +M +VI N + N R++ YD +QY+QN+IPY
Sbjct: 2119 FVATKNNKEAAAHMLAVIRNSYQNFRTRTYDMIQYYQNQIPY 2160
>gi|47226674|emb|CAG07833.1| unnamed protein product [Tetraodon
nigroviridis]
Length = 1246
Score = 946 bits (2444), Expect = 0.0
Identities = 536/1308 (40%), Positives = 771/1308 (57%), Gaps = 68/1308 (5%)
Frame = -1
Query: 3723 LIHANHVDAFSSFFKYIEDKTMRKDKSGLWTCMLAAAPRIFLEWCEKMMKRRDNDEPTEE 3544
++ +N D F F+Y EDK ++KDKSG+ C++ ++F + + MM + + EE
Sbjct: 1 MLRSNDPDRFQVMFRYFEDKAIQKDKSGMMQCIICVGDKVFAVFLQ-MMAEKPRTKEHEE 59
Query: 3543 ALVWHAQFLLFKFNHHLREVRKVADACLSQLVKAFPYLLWNTKVLTTILRLLQELEDNLQ 3364
L HAQFLL FNH + +R+VAD LS L FP+LLW+ +VL T+L +LQ L +L
Sbjct: 60 ELERHAQFLLVNFNHTHKRIRRVADKYLSGLADTFPHLLWSGRVLKTMLDILQTLSLSLS 119
Query: 3363 KDPTCREPQFTIEGFGGWTIQLQDSIEGRRSVVKDFSMRVKQILKEALRWAPASTHSNLL 3184
D +P + I + I + D+ E R ++VKDF+ R +ILKEA++WAP+ T S+L
Sbjct: 120 ADIHKDQPYYDIPDTP-YRITVPDTYEARENIVKDFAARCGEILKEAMKWAPSVTKSHLQ 178
Query: 3183 EYVSKF-----GSERDAAMQLAIDATSEGSGKS----------------------GSYLT 3085
EY++K G + + +A ++ +G + +++
Sbjct: 179 EYLNKHQNWVSGLSQHTGLAMATESILHFAGYNRQSTTLGATQLTERPACVKKDYSNFMA 238
Query: 3084 SLYKRSNYLGQVKGML----ATTLSGDIDQVTAENQLIDRLEKDFQRACKSGKDME-MEQ 2920
SL R+ Y G+V GM+ AT D+ ++ Q+ LEK KD E Q
Sbjct: 239 SLNLRNRYTGEVAGMIQFSEATQTRSDLSKLLIY-QMTSVLEK---------KDPEAFTQ 288
Query: 2919 AVLLLTALFVSLRSLNERILSLLVRTPLLNFTESTVSLCTMAWNWLLSARPEAHSLFLHE 2740
A+ + AL ++ ++ + +L L +PL FTE ++ W WLL+A F+ E
Sbjct: 289 AMFKMAALLITTKNCDPLLLHHLCWSPLKMFTEHSMETAIACWEWLLAAHNGVEVPFMRE 348
Query: 2739 QARAFADSSRFGLGLFEKEVVGGSPLCQKLE-RPPPSA-NFRPHREWIEFIGERCDVASY 2566
A A+ + +GLF + V PL E +P P A PH WIEF+ +R ++A Y
Sbjct: 349 MAGAWQMTVELKMGLFSETKVEAGPLAVSEESQPTPCAPEVIPHFLWIEFLVQRFEIAKY 408
Query: 2565 SSREQLDVLEMMFSQTLSAHIGTGHLHGSTACSNPASLAGPSRKETINQVTRGIEAVGVR 2386
SS +Q+++ + ++LS +G GP K ++N R + A+G R
Sbjct: 409 SSADQVEIFTAILQRSLSLSVG-----------------GP--KSSLN---RHVAAIGPR 446
Query: 2385 FRLLSCVLGMVQQDACLLRPTNVLIRQRVYSCAFHYFTIAPQGPTQPEERLREDIRLLTR 2206
FRLL+ L ++ D ++R+++YS F YF+ P+ PTQ ++RLREDI ++ +
Sbjct: 447 FRLLTLGLTLLHADVVTNATIKNVLREKIYSTGFDYFSTTPKFPTQTDKRLREDISIMIK 506
Query: 2205 FFEHLKNDKHYMQKEALAKTDKNLVMSSTMSQMQTNFEKSLLISXXXXXXXXXXXXXTSL 2026
F+ L++DK Y+ L D + +++S + +S L +
Sbjct: 507 FYASLQSDKRYLTAHQLVPPDPQEMSVNSLSVVAVTESRSSLDAAVGQRQ---------- 556
Query: 2025 MLPPSTNYANTLTLSSQKSMAATSASIRSGKSIETKLSIEEDRRIKTWMKQRNMLMLLV- 1849
P + + NT LSS S + S +SG S K S + K +MK+R +L+ L+
Sbjct: 557 --PVTQGWINTYPLSSGMS----TISKKSGLS---KKSNRGSQLHKYYMKRRTLLLALLV 607
Query: 1848 --------------------------------ANEIERLSAWLHPLALAQEDCALDSEEF 1765
ANEIERL+ W +PL+ + A++
Sbjct: 608 FSSVRSLFKPPTKIQPLFQFQFCRFLFTLCLQANEIERLTIWYNPLSTQELAIAMEQSVE 667
Query: 1764 LRGAFTQAKATGGEKNIWREQAQLAWDISPELAIQLPSRFRGSPELVKYVDVLVRGQPEP 1585
A ++K + W++ LAW I+P LA+QLP+RF+ + +V V LVR P
Sbjct: 668 TSIANWRSKYISLTEKQWKDNVNLAWSIAPYLALQLPARFKNTEAIVSEVTRLVRMDPSA 727
Query: 1584 VAHIPEALPLFLGNGSTVFETSDMSHVLTWARCSPVMALSLLTPRIYPMHPISMQYAVRV 1405
V +PEA+ + + ++ ++S++L WA P LS + +YP HP++ QY V+V
Sbjct: 728 VCDVPEAVKFLVTWHTIDADSPELSYILCWAPADPPTGLSYFSS-LYPPHPLTAQYGVKV 786
Query: 1404 LRSYSADELLLYIPQIVQAVRYDTMGYISELIIWLAGHSQLLSHQLIWNMQTNMFTDEES 1225
LRS+ D +L YIPQIVQA+RYD MGY+ E I+W A SQLL+HQ IWNM+TN+F DEE
Sbjct: 787 LRSFPPDAILFYIPQIVQALRYDKMGYVREYILWAAQKSQLLAHQFIWNMKTNIFLDEEG 846
Query: 1224 KVKDPVLFEALNDIMQKILSQLEGAARRFHEAEFKLFHQLTAISGTIKPFPKGDARKKAC 1045
KDP + E L ++++I L G A+ F++ EF F+++T +S IKPFPKG+ RK+AC
Sbjct: 847 SQKDPDIGELLEQMVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPFPKGEERKRAC 906
Query: 1044 LKALADVKIETITYLPSNPEAVLLDLDYSSGTPMQSAAKAPFLARFRVKRCGVRELEHIG 865
L+ L+ ++++ YLPSNPEA++LD+DY SGTPMQSAAKAP+LA+F+VKRCGV ELE G
Sbjct: 907 LETLSQIQVQPGCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEG 966
Query: 864 LQAQSEHGGKTTEADLEELKKVQDS-RVCWQAAIFKVGDDVRXXXXXXXXXXXMKNVWAG 688
LQ +++ +E+K +++ R+CWQAAIFKVGDD R KN++
Sbjct: 967 LQCRADSE--------DEVKSEEEAKRICWQAAIFKVGDDCRQDMLALQIISLFKNIFQL 1018
Query: 687 LGLPVRVFPYRVVATSPGCGVIECVPNSKSRDQLGRQTDFGLYEYFKTQYGDESSETFQE 508
+GL + VFPYRVVAT+PGCGVIEC+P+ KSRDQLGRQTDFG+Y+YF+ QYGDES+ FQ+
Sbjct: 1019 VGLDLYVFPYRVVATAPGCGVIECIPDCKSRDQLGRQTDFGMYDYFRNQYGDESTLAFQK 1078
Query: 507 ARRNFVRSMAAYSVFSFLLQIKDRHNGNIMIDLDGHIIHIDFGFMFESSPGGNLGFEPDF 328
AR NF+RSMAAYS+ FLLQIKDRHNGNIM+D GH+IHIDFGFMFESSPGGNLG+EPD
Sbjct: 1079 ARYNFIRSMAAYSLVLFLLQIKDRHNGNIMLDSQGHLIHIDFGFMFESSPGGNLGWEPDI 1138
Query: 327 KLSEEMVAIMGGKMEAAPFRQFASLCVHAYLAVRPYHKSFVSLVSLMLDTHLPCFRGKTI 148
KL++EMV IMGGKMEA PF+ F +CV YLAVRPY + VSLV+LMLDT LPCFRG+TI
Sbjct: 1139 KLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFRGQTI 1198
Query: 147 NQLRARFAPEMNEKDAAKYMYSVITNCFLNIRSKMYDQLQYFQNEIPY 4
L+ RF P ++EKDAA ++ VI NCFL+ RS+ YD +QY+QN+IPY
Sbjct: 1199 KLLKQRFNPGLSEKDAASFIIKVIQNCFLSNRSRTYDMIQYYQNQIPY 1246
>gi|21064847|gb|AAM29653.1| SD12145p [Drosophila melanogaster]
Length = 1308
Score = 939 bits (2427), Expect = 0.0
Identities = 549/1370 (40%), Positives = 802/1370 (58%), Gaps = 39/1370 (2%)
Frame = -1
Query: 3996 SSSLWPEEWYNAVCETATKTPVLIATENLRSELID---NAAIRSDSISPQELQEMRNTVL 3826
++ LWP +WY V + A K+P+LI+ +S++ + AI+SDS++ E+R+ +L
Sbjct: 5 NARLWPADWYQGVQQIAAKSPLLISQTAHKSDMRELNYTLAIKSDSVN-----ELRSQIL 59
Query: 3825 AELSHQAEAVPL-INRFDFANCTYLLSVHRMETMRLIHANHVDAFSSFFKYIEDKTMRKD 3649
L H ++ V IN+ FA CTYLLSV+ +E +R+ +A+ + Y+ D +++D
Sbjct: 60 VLLEHSSDNVATAINKLSFAQCTYLLSVYWLEMLRVENADE-PSLEPIMSYLCDTALQRD 118
Query: 3648 KSGLWTCMLAAAPRIFLEWCEKMMKRRDNDEPTEEALVWHAQFLLFKFNHHLREVRKVAD 3469
K+G+W C+ A ++F ++ + +DE E+ L A LL FNH + ++ VAD
Sbjct: 119 KTGIWQCVKCVADQVFEKFRNVLYA---HDEIREKVLESQATLLLVYFNHIHKPIQMVAD 175
Query: 3468 ACLSQLVKAFPYLLWNTKVLTTILRLLQELEDNLQKDPTCREPQFTIEGFGGWTIQLQDS 3289
LS LV FP+LLWN +VL +L +LQ L +L DP P + +T+QL DS
Sbjct: 176 QYLSFLVDRFPHLLWNRRVLWCMLDILQLLAYSLSLDPNEETPTLRVVSTP-YTLQLMDS 234
Query: 3288 IEGRRSVVKDFSMRVKQILKEALRWAPASTHSNLLEYVSKFGSE---RDAAMQLAIDATS 3118
+ R +KDF+ R + I+ EA++WAP ST S+L EY ++ + + + LA D+
Sbjct: 235 LPARELRLKDFADRCQGIVNEAMKWAPRSTRSHLQEYPNQIPTPVLAHHSGLALAFDSVV 294
Query: 3117 EGSGK---------------SGSYLTSLYKRSNYLGQVKGMLATTLSGDIDQVTAENQLI 2983
S + + +++ L RS Y G++ G+L+ D + L
Sbjct: 295 SSSAQHTGTMSKRPSCVNSDTPRFVSVLCLRSKYAGEISGLLSVLSEKD------KAGLA 348
Query: 2982 DRLEKDFQRACKSGKDMEMEQAVLLLTALFVSLRSLNERILSLLVRTPLLNFTESTVSLC 2803
DRL D AC D A+ TA + ++ ++L + + L FTES +
Sbjct: 349 DRLVSDVWEACAEKSDARHRGALWRATAYLIICSEISRKLLHAVASSQLELFTESAMETA 408
Query: 2802 TMAWNWLLSARPEAHSLFLHEQARAFADSSRFGLGLFEKEVVGGSPL-----CQKLERPP 2638
W W+L+AR + F+ E A+ + +GLF E PL C+ + +P
Sbjct: 409 VECWQWVLTARQDLELCFIQEMVSAWQTTFEKRMGLFAWETEVTHPLAAYEGCKLVSKPI 468
Query: 2637 PSANFRPHREWIEFIGERCDVASYSSREQLDVLEMMFSQTLSAHIGTGHLHGSTACSNPA 2458
A PH W++ + E D A Y +R+++++ ++ + L
Sbjct: 469 LIA---PHLIWLQLLSEMVDTAKYCNRDKVEMFCLLLHRCL------------------- 506
Query: 2457 SLAGPSRKETINQVTRGIEAVGVRFRLLSCVLGMVQQDACLLRPTNVLIRQRVYSCAFHY 2278
P K + + R + VG RF+LL C L ++Q + + ++R+R+YS A Y
Sbjct: 507 ----PVLKSS--KQNRQVSTVGCRFKLLQCGLSLLQGNTIPKSLSRNILRERIYSNALDY 560
Query: 2277 FTIAPQGPTQPEERLREDIRLLTRFFEHLKNDKHYMQKEALAKTD-KNLVMSST-MSQMQ 2104
F P P Q E+L EDI +L +F++ ++++K ++ + D N +SST M ++
Sbjct: 561 FCGPPTCPNQSREQLLEDIMILLKFWQTMRSEKKHLVTSEVGDYDLTNASVSSTQMLAVR 620
Query: 2103 TNFEKSLLISXXXXXXXXXXXXXTSLMLP----------PSTNYANTLTLSSQKSMAATS 1954
N E + LIS S S+ + NT+ S+ ++
Sbjct: 621 NNPETASLISGGGLVNDYTRSMSASGNAVGMGMGVAGGGSSSGWYNTIPHST------ST 674
Query: 1953 ASIRSGKSIETKLSIEEDRRIKTWMKQRNMLMLLVANEIERLSAWLHPLALAQEDCALDS 1774
S RS +S +L ++D K +MK+RN+++ L+A E+E L W +P +L D +
Sbjct: 675 LSKRSNRS--KRLQYQKDSYDKDYMKKRNLILELLAVELEFLITWYNPNSLP--DLIVPG 730
Query: 1773 EEFLRGAFTQAKATGGEKNIWREQAQLAWDISPELAIQLPSRFRGSPELVKYVDVLVRGQ 1594
EE + T+ + + +WR+ A+LAW +P LA+ LP R + + + + V LV
Sbjct: 731 EEQI----TEWRNRPYKSTVWRDYARLAWCYNPALAVFLPQRIKNAEIIDEEVSRLVCSD 786
Query: 1593 PEPVAHIPEALPLFLGNGSTVFETSDMSHVLTWARCSPVMALSLLTPRIYPMHPISMQYA 1414
P V HIPEAL + + E+ D+ ++L+W+ +P+ AL+ + R YP HP++ QYA
Sbjct: 787 PIAVCHIPEALKYLCTTKNLLQESPDLVYILSWSPVTPIQALAYFS-RQYPSHPLTAQYA 845
Query: 1413 VRVLRSYSADELLLYIPQIVQAVRYDTMGYISELIIWLAGHSQLLSHQLIWNMQTNMFTD 1234
V+ L SY A+ +L YIPQ+VQA+R+DTMGY+ E I ++ SQ+++HQLIWNMQTNM+ D
Sbjct: 846 VKTLSSYPAESVLPYIPQLVQALRHDTMGYVVEFIKNISRRSQIVAHQLIWNMQTNMYMD 905
Query: 1233 EESKVKDPVLFEALNDIMQKILSQLEGAARRFHEAEFKLFHQLTAISGTIKPFPKGDARK 1054
E+ + KDP L+EAL+ + Q I++ GAA+RF+E EF F ++TA+SG I+ F KG RK
Sbjct: 906 EDQQHKDPNLYEALDQLSQSIIASFSGAAKRFYEREFDFFGKITAVSGEIRSFAKGIERK 965
Query: 1053 KACLKALADVKIETITYLPSNPEAVLLDLDYSSGTPMQSAAKAPFLARFRVKRCGVRELE 874
ACL AL+ +K++ YLPSNPEA++LD+DYSSGTPMQSAAKAP+LARFRV RCG+ ELE
Sbjct: 966 NACLAALSRIKVQGGCYLPSNPEAMVLDIDYSSGTPMQSAAKAPYLARFRVYRCGITELE 1025
Query: 873 HIGLQAQSEHGGKTTEADLEELKKVQDSRVCWQAAIFKVGDDVRXXXXXXXXXXXMKNVW 694
+A ++ D + V+ WQAAIFKVGDDVR KN++
Sbjct: 1026 ---TRAMEVSNNPNSQEDAKMTLGVES----WQAAIFKVGDDVRQDMLALQVITIFKNIF 1078
Query: 693 AGLGLPVRVFPYRVVATSPGCGVIECVPNSKSRDQLGRQTDFGLYEYFKTQYGDESSETF 514
+GL + +FPYRVVAT+PGCGVIECVPN+KSRDQLGRQTD GL EYF+ QYGDESS+ F
Sbjct: 1079 QQVGLDLFLFPYRVVATAPGCGVIECVPNAKSRDQLGRQTDSGLSEYFQHQYGDESSKEF 1138
Query: 513 QEARRNFVRSMAAYSVFSFLLQIKDRHNGNIMIDLDGHIIHIDFGFMFESSPGGNLGFEP 334
Q AR NFV+SMAAYS+ +LLQIKDRHNGNIMID DGHIIHIDFGFMFESSPGGN+GFEP
Sbjct: 1139 QAARANFVKSMAAYSLIGYLLQIKDRHNGNIMIDKDGHIIHIDFGFMFESSPGGNIGFEP 1198
Query: 333 DFKLSEEMVAIMGGKMEAAPFRQFASLCVHAYLAVRPYHKSFVSLVSLMLDTHLPCFRGK 154
D KL++EMV IMGGKM++ F+ F LCV A+LAVRPY + VSLVSLMLDT LPCFRG+
Sbjct: 1199 DMKLTDEMVMIMGGKMDSPAFKWFCELCVQAFLAVRPYQDAIVSLVSLMLDTGLPCFRGQ 1258
Query: 153 TINQLRARFAPEMNEKDAAKYMYSVITNCFLNIRSKMYDQLQYFQNEIPY 4
TIN L+ RF N K+AA +M +VI N + N R++ YD +QY+QN+IPY
Sbjct: 1259 TINLLKQRFVATKNNKEAAAHMLAVIRNSYQNFRTRTYDMIQYYQNQIPY 1308
>gi|32425423|gb|AAH18120.2| PIK4CA protein [Homo sapiens]
Length = 903
Score = 786 bits (2029), Expect = 0.0
Identities = 426/967 (44%), Positives = 594/967 (61%), Gaps = 4/967 (0%)
Frame = -1
Query: 2892 VSLRSLNERILSLLVRTPLLNFTESTVSLCTMAWNWLLSARPEAHSLFLHEQARAFADSS 2713
+S + + ++L L PL F E + W WLL+ + F+ E A A+ +
Sbjct: 2 ISSKDCDPQLLHHLCWGPLRMFNEHGMETALACWEWLLAGKDGVEVPFMREMAGAWHMTV 61
Query: 2712 RFGLGLFEKEVVGGSPLC-QKLERPPPSA-NFRPHREWIEFIGERCDVASYSSREQLDVL 2539
GLF E+ PL + +P P PH WI+F+ +R ++A Y S +Q+++
Sbjct: 62 EQKFGLFSAEIKEADPLAASEASQPKPCPPEVTPHYIWIDFLVQRFEIAKYCSSDQVEIF 121
Query: 2538 EMMFSQTLSAHIGTGHLHGSTACSNPASLAGPSRKETINQVTRGIEAVGVRFRLLSCVLG 2359
+ +++S +IG K ++N R + A+G RF+LL+ L
Sbjct: 122 SSLLQRSMSLNIG-------------------GAKGSMN---RHVAAIGPRFKLLTLGLS 159
Query: 2358 MVQQDACLLRPTNVLIRQRVYSCAFHYFTIAPQGPTQPEERLREDIRLLTRFFEHLKNDK 2179
++ D ++R+++YS AF YF+ P+ PTQ E+RLREDI ++ +F+ + +DK
Sbjct: 160 LLHADVVPNATIRNVLREKIYSTAFDYFSCPPKFPTQGEKRLREDISIMIKFWTAMFSDK 219
Query: 2178 HYMQKEALAKTDKNLVMSSTMSQMQTNFEKSLLISXXXXXXXXXXXXXTSLMLPPSTNYA 1999
Y+ L D S+ + + + + +
Sbjct: 220 KYLTASQLVPPDNQDTRSNLDITVGSRQQAT-------------------------QGWI 254
Query: 1998 NTLTLSSQKSMAATSASIRSGKSIETKLSIEEDRRIKTWMKQRNMLMLLVANEIERLSAW 1819
NT LSS S + S +SG S +T + K +MK+R +L+ L+A EIERL W
Sbjct: 255 NTYPLSSGMS----TISKKSGMSKKTNRGSQLH---KYYMKRRTLLLSLLATEIERLITW 307
Query: 1818 LHPLALAQEDCALDSEEFLRGAFTQAKATGGEKNIWREQAQLAWDISPELAIQLPSRFRG 1639
+PL+ + + E + A ++K + W++ LAW ISP LA+QLP+RF+
Sbjct: 308 YNPLSAPELELDQAGENSV--ANWRSKYISLSEKQWKDNVNLAWSISPYLAVQLPARFKN 365
Query: 1638 SPELVKYVDVLVRGQPEPVAHIPEALPLFLGNGSTVFETSDMSHVLTWARCSPVMALSLL 1459
+ + V LVR P V+ +PEA+ + + + ++SHVL WA P LS
Sbjct: 366 TEAIGNEVTRLVRLDPGAVSDVPEAIKFLVTWHTIDADAPELSHVLCWAPTDPPTGLSYF 425
Query: 1458 TPRIYPMHPISMQYAVRVLRSYSADELLLYIPQIVQAVRYDTMGYISELIIWLAGHSQLL 1279
+ +YP HP++ QY V+VLRS+ D +L YIPQIVQA+RYD MGY+ E I+W A SQLL
Sbjct: 426 SS-MYPPHPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYDKMGYVREYILWAASKSQLL 484
Query: 1278 SHQLIWNMQTNMFTDEESKVKDPVLFEALNDIMQKILSQLEGAARRFHEAEFKLFHQLTA 1099
+HQ IWNM+TN++ DEE KDP + + L+ ++++I L G A+ F++ EF F+++T
Sbjct: 485 AHQFIWNMKTNIYLDEEGHQKDPDIGDLLDQLVEEITGSLSGPAKDFYQREFDFFNKITN 544
Query: 1098 ISGTIKPFPKGDARKKACLKALADVKIETITYLPSNPEAVLLDLDYSSGTPMQSAAKAPF 919
+S IKP+PKGD RKKACL AL++VK++ YLPSNPEA++LD+DY SGTPMQSAAKAP+
Sbjct: 545 VSAIIKPYPKGDERKKACLSALSEVKVQPGCYLPSNPEAIVLDIDYKSGTPMQSAAKAPY 604
Query: 918 LARFRVKRCGVRELEHIGLQAQSEHGGK--TTEADLEELKKVQDSRVCWQAAIFKVGDDV 745
LA+F+VKRCGV ELE GL+ +S+ + T EAD ++ WQAAIFKVGDD
Sbjct: 605 LAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEAD--------GQKISWQAAIFKVGDDC 656
Query: 744 RXXXXXXXXXXXMKNVWAGLGLPVRVFPYRVVATSPGCGVIECVPNSKSRDQLGRQTDFG 565
R KN++ +GL + VFPYRVVAT+PGCGVIEC+P+ SRDQLGRQTDFG
Sbjct: 657 RQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQLGRQTDFG 716
Query: 564 LYEYFKTQYGDESSETFQEARRNFVRSMAAYSVFSFLLQIKDRHNGNIMIDLDGHIIHID 385
+Y+YF QYGDES+ FQ+AR NF+RSMAAYS+ FLLQIKDRHNGNIM+D GHIIHID
Sbjct: 717 MYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHID 776
Query: 384 FGFMFESSPGGNLGFEPDFKLSEEMVAIMGGKMEAAPFRQFASLCVHAYLAVRPYHKSFV 205
FGFMFESSPGGNLG+EPD KL++EMV IMGGKMEA PF+ F +CV YLAVRPY + V
Sbjct: 777 FGFMFESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVV 836
Query: 204 SLVSLMLDTHLPCFRGKTINQLRARFAPEMNEKDAAKYMYSVITNCFLNIRSKMYDQLQY 25
SLV+LMLDT LPCFRG+TI L+ RF+P M E++AA ++ VI +CFL+ RS+ YD +QY
Sbjct: 837 SLVTLMLDTGLPCFRGQTIKLLKHRFSPNMTEREAANFIMKVIQSCFLSNRSRTYDMIQY 896
Query: 24 FQNEIPY 4
+QN+IPY
Sbjct: 897 YQNDIPY 903
>gi|32197216|gb|AAH53654.1| PIK4CA protein [Homo sapiens]
Length = 895
Score = 781 bits (2017), Expect = 0.0
Identities = 424/959 (44%), Positives = 589/959 (61%), Gaps = 4/959 (0%)
Frame = -1
Query: 2868 RILSLLVRTPLLNFTESTVSLCTMAWNWLLSARPEAHSLFLHEQARAFADSSRFGLGLFE 2689
++L L PL F E + W WLL+ + F+ E A A+ + GLF
Sbjct: 2 QLLHHLCWGPLRMFNEHGMETALACWEWLLAGKDGVEVPFMREMAGAWHMTVEQKFGLFS 61
Query: 2688 KEVVGGSPLC-QKLERPPPSA-NFRPHREWIEFIGERCDVASYSSREQLDVLEMMFSQTL 2515
E+ PL + +P P PH WI+F+ +R ++A Y S +Q+++ + +++
Sbjct: 62 AEIKEADPLAASEASQPKPCPPEVTPHYIWIDFLVQRFEIAKYCSSDQVEIFSSLLQRSM 121
Query: 2514 SAHIGTGHLHGSTACSNPASLAGPSRKETINQVTRGIEAVGVRFRLLSCVLGMVQQDACL 2335
S +IG K ++N R + A+G RF+LL+ L ++ D
Sbjct: 122 SLNIG-------------------GAKGSMN---RHVAAIGPRFKLLTLGLSLLHADVVP 159
Query: 2334 LRPTNVLIRQRVYSCAFHYFTIAPQGPTQPEERLREDIRLLTRFFEHLKNDKHYMQKEAL 2155
++R+++YS AF YF+ P+ PTQ E+RLREDI ++ +F+ + +DK Y+ L
Sbjct: 160 NATIRNVLREKIYSTAFDYFSCPPKFPTQGEKRLREDISIMIKFWTAMFSDKKYLTASQL 219
Query: 2154 AKTDKNLVMSSTMSQMQTNFEKSLLISXXXXXXXXXXXXXTSLMLPPSTNYANTLTLSSQ 1975
D S+ + + + + + NT LSS
Sbjct: 220 VPPDNQDTRSNLDITVGSRQQAT-------------------------QGWINTYPLSSG 254
Query: 1974 KSMAATSASIRSGKSIETKLSIEEDRRIKTWMKQRNMLMLLVANEIERLSAWLHPLALAQ 1795
S + S +SG S +T + K +MK+R +L+ L+A EIERL W +PL+ +
Sbjct: 255 MS----TISKKSGMSKKTNRGSQLH---KYYMKRRTLLLSLLATEIERLITWYNPLSAPE 307
Query: 1794 EDCALDSEEFLRGAFTQAKATGGEKNIWREQAQLAWDISPELAIQLPSRFRGSPELVKYV 1615
+ E + A ++K + W++ LAW ISP LA+QLP+RF+ + + V
Sbjct: 308 LELDQAGENSV--ANWRSKYISLSEKQWKDNVNLAWSISPYLAVQLPARFKNTEAIGNEV 365
Query: 1614 DVLVRGQPEPVAHIPEALPLFLGNGSTVFETSDMSHVLTWARCSPVMALSLLTPRIYPMH 1435
LVR P V+ +PEA+ + + + ++SHVL WA P LS + +YP H
Sbjct: 366 TRLVRLDPGAVSDVPEAIKFLVTWHTIDADAPELSHVLCWAPTDPPTGLSYFSS-MYPPH 424
Query: 1434 PISMQYAVRVLRSYSADELLLYIPQIVQAVRYDTMGYISELIIWLAGHSQLLSHQLIWNM 1255
P++ QY V+VLRS+ D +L YIPQIVQA+RYD MGY+ E I+W A SQLL+HQ IWNM
Sbjct: 425 PLTAQYGVKVLRSFPPDAILFYIPQIVQALRYDKMGYVREYILWAASKSQLLAHQFIWNM 484
Query: 1254 QTNMFTDEESKVKDPVLFEALNDIMQKILSQLEGAARRFHEAEFKLFHQLTAISGTIKPF 1075
+TN++ DEE KDP + + L+ ++++I L G A+ F++ EF F+++T +S IKP+
Sbjct: 485 KTNIYLDEEGHQKDPDIGDLLDQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPY 544
Query: 1074 PKGDARKKACLKALADVKIETITYLPSNPEAVLLDLDYSSGTPMQSAAKAPFLARFRVKR 895
PKGD RKKACL AL++VK++ YLPSNPEA++LD+DY SGTPMQSAAKAP+LA+F+VKR
Sbjct: 545 PKGDERKKACLSALSEVKVQPGCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKR 604
Query: 894 CGVRELEHIGLQAQSEHGGK--TTEADLEELKKVQDSRVCWQAAIFKVGDDVRXXXXXXX 721
CGV ELE GL+ +S+ + T EAD ++ WQAAIFKVGDD R
Sbjct: 605 CGVSELEKEGLRCRSDSEDECSTQEAD--------GQKISWQAAIFKVGDDCRQDMLALQ 656
Query: 720 XXXXMKNVWAGLGLPVRVFPYRVVATSPGCGVIECVPNSKSRDQLGRQTDFGLYEYFKTQ 541
KN++ +GL + VFPYRVVAT+PGCGVIEC+P+ SRDQLGRQTDFG+Y+YF Q
Sbjct: 657 IIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQLGRQTDFGMYDYFTRQ 716
Query: 540 YGDESSETFQEARRNFVRSMAAYSVFSFLLQIKDRHNGNIMIDLDGHIIHIDFGFMFESS 361
YGDES+ FQ+AR NF+RSMAAY + FLLQIKDRHNGNIM+D GHIIHIDFGFMFESS
Sbjct: 717 YGDESTLAFQQARYNFIRSMAAYILLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFMFESS 776
Query: 360 PGGNLGFEPDFKLSEEMVAIMGGKMEAAPFRQFASLCVHAYLAVRPYHKSFVSLVSLMLD 181
PGGNLG+EPD KL++EMV IMGGKMEA PF+ F +CV YLAVRPY + VSLV+LMLD
Sbjct: 777 PGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLD 836
Query: 180 THLPCFRGKTINQLRARFAPEMNEKDAAKYMYSVITNCFLNIRSKMYDQLQYFQNEIPY 4
T LPCFRG+TI L+ RF+P M E++AA ++ VI +CFL+ RS+ YD +QY+QN+IPY
Sbjct: 837 TGLPCFRGQTIKLLKHRFSPNMTEREAANFIMKVIQSCFLSNRSRTYDMIQYYQNDIPY 895
>gi|4505807|ref|NP_002641.1| phosphatidylinositol 4-kinase, catalytic,
alpha polypeptide isoform 1; phosphatidylinositol
4-kinase, type II, alpha; phosphatidylinositol 4-kinase,
type III, alpha; phosphatidylinositol 4-kinase 230 [Homo
sapiens]
gi|1079473|pir||A55404 1-phosphatidylinositol 4-kinase (EC 2.7.1.67)
alpha - human
gi|598193|gb|AAA56839.1| phosphatidylinositol 4-kinase
Length = 854
Score = 766 bits (1978), Expect = 0.0
Identities = 414/919 (45%), Positives = 574/919 (62%), Gaps = 4/919 (0%)
Frame = -1
Query: 2748 LHEQARAFADSSRFGLGLFEKEVVGGSPLC-QKLERPPPSA-NFRPHREWIEFIGERCDV 2575
+ E A A+ + GLF E+ PL + +P P PH WI+F+ +R ++
Sbjct: 1 MREMAGAWHMTVEQKFGLFSAEIKEADPLAASEASQPKPCPPEVTPHYIWIDFLVQRFEI 60
Query: 2574 ASYSSREQLDVLEMMFSQTLSAHIGTGHLHGSTACSNPASLAGPSRKETINQVTRGIEAV 2395
A Y S +Q+++ + +++S +IG K ++N R + A+
Sbjct: 61 AKYCSSDQVEIFSSLLQRSMSLNIG-------------------GAKGSMN---RHVAAI 98
Query: 2394 GVRFRLLSCVLGMVQQDACLLRPTNVLIRQRVYSCAFHYFTIAPQGPTQPEERLREDIRL 2215
G RF+LL+ L ++ D ++R+++YS AF YF+ P+ PTQ E+RLREDI +
Sbjct: 99 GPRFKLLTLGLSLLHADVVPNATIRNVLREKIYSTAFDYFSCPPKFPTQGEKRLREDISI 158
Query: 2214 LTRFFEHLKNDKHYMQKEALAKTDKNLVMSSTMSQMQTNFEKSLLISXXXXXXXXXXXXX 2035
+ +F+ + +DK Y+ L D S+ + + + +
Sbjct: 159 MIKFWTAMFSDKKYLTASQLVPPDNQDTRSNLDITVGSRQQAT----------------- 201
Query: 2034 TSLMLPPSTNYANTLTLSSQKSMAATSASIRSGKSIETKLSIEEDRRIKTWMKQRNMLML 1855
+ NT LSS S + S +SG S +T + K +MK+R +L+
Sbjct: 202 --------QGWINTYPLSSGMS----TISKKSGMSKKTNRGSQLH---KYYMKRRTLLLS 246
Query: 1854 LVANEIERLSAWLHPLALAQEDCALDSEEFLRGAFTQAKATGGEKNIWREQAQLAWDISP 1675
L+A EIERL W +PL+ + + E + A ++K + W++ LAW ISP
Sbjct: 247 LLATEIERLITWYNPLSAPELELDQAGENSV--ANWRSKYISLSEKQWKDNVNLAWSISP 304
Query: 1674 ELAIQLPSRFRGSPELVKYVDVLVRGQPEPVAHIPEALPLFLGNGSTVFETSDMSHVLTW 1495
LA+QLP+RF+ + + V LVR P V+ +PEA+ + + + ++SHVL W
Sbjct: 305 YLAVQLPARFKNTEAIGNEVTRLVRLDPGAVSDVPEAIKFLVTWHTIDADAPELSHVLCW 364
Query: 1494 ARCSPVMALSLLTPRIYPMHPISMQYAVRVLRSYSADELLLYIPQIVQAVRYDTMGYISE 1315
A P LS + +YP HP++ QY V+VLRS+ D +L YIPQIVQA+RYD MGY+ E
Sbjct: 365 APTDPPTGLSYFSS-MYPPHPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYDKMGYVRE 423
Query: 1314 LIIWLAGHSQLLSHQLIWNMQTNMFTDEESKVKDPVLFEALNDIMQKILSQLEGAARRFH 1135
I+W A SQLL+HQ IWNM+TN++ DEE KDP + + L+ ++++I L G A+ F+
Sbjct: 424 YILWAASKSQLLAHQFIWNMKTNIYLDEEGHQKDPDIGDLLDQLVEEITGSLSGPAKDFY 483
Query: 1134 EAEFKLFHQLTAISGTIKPFPKGDARKKACLKALADVKIETITYLPSNPEAVLLDLDYSS 955
+ EF F+++T +S IKP+PKGD RKKACL AL++VK++ YLPSNPEA++LD+DY S
Sbjct: 484 QREFDFFNKITNVSAIIKPYPKGDERKKACLSALSEVKVQPGCYLPSNPEAIVLDIDYKS 543
Query: 954 GTPMQSAAKAPFLARFRVKRCGVRELEHIGLQAQSEHGGK--TTEADLEELKKVQDSRVC 781
GTPMQSAAKAP+LA+F+VKRCGV ELE GL+ +S+ + T EAD ++
Sbjct: 544 GTPMQSAAKAPYLAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEAD--------GQKIS 595
Query: 780 WQAAIFKVGDDVRXXXXXXXXXXXMKNVWAGLGLPVRVFPYRVVATSPGCGVIECVPNSK 601
WQAAIFKVGDD R KN++ +GL + VFPYRVVAT+PGCGVIEC+P+
Sbjct: 596 WQAAIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCT 655
Query: 600 SRDQLGRQTDFGLYEYFKTQYGDESSETFQEARRNFVRSMAAYSVFSFLLQIKDRHNGNI 421
SRDQLGRQTDFG+Y+YF QYGDES+ FQ+AR NF+RSMAAYS+ FLLQIKDRHNGNI
Sbjct: 656 SRDQLGRQTDFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNI 715
Query: 420 MIDLDGHIIHIDFGFMFESSPGGNLGFEPDFKLSEEMVAIMGGKMEAAPFRQFASLCVHA 241
M+D GHIIHIDFGFMFESSPGGNLG+EPD KL++EMV IMGGKMEA PF+ F +CV
Sbjct: 716 MLDKKGHIIHIDFGFMFESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVRG 775
Query: 240 YLAVRPYHKSFVSLVSLMLDTHLPCFRGKTINQLRARFAPEMNEKDAAKYMYSVITNCFL 61
YLAVRPY + VSLV+LMLDT LPCFRG+TI L+ RF+P M E++AA ++ VI +CFL
Sbjct: 776 YLAVRPYMDAVVSLVTLMLDTGLPCFRGQTIKLLKHRFSPNMTEREAANFIMKVIQSCFL 835
Query: 60 NIRSKMYDQLQYFQNEIPY 4
+ RS+ YD +QY+QN+IPY
Sbjct: 836 SNRSRTYDMIQYYQNDIPY 854
>gi|30584637|gb|AAP36571.1| Homo sapiens phosphatidylinositol
4-kinase, catalytic, alpha polypeptide [synthetic
construct]
gi|33303915|gb|AAQ02471.1| phosphatidylinositol 4-kinase, catalytic,
alpha polypeptide [synthetic construct]
Length = 855
Score = 766 bits (1978), Expect = 0.0
Identities = 414/919 (45%), Positives = 574/919 (62%), Gaps = 4/919 (0%)
Frame = -1
Query: 2748 LHEQARAFADSSRFGLGLFEKEVVGGSPLC-QKLERPPPSA-NFRPHREWIEFIGERCDV 2575
+ E A A+ + GLF E+ PL + +P P PH WI+F+ +R ++
Sbjct: 1 MREMAGAWHMTVEQKFGLFSAEIKEADPLAASEASQPKPCPPEVTPHYIWIDFLVQRFEI 60
Query: 2574 ASYSSREQLDVLEMMFSQTLSAHIGTGHLHGSTACSNPASLAGPSRKETINQVTRGIEAV 2395
A Y S +Q+++ + +++S +IG K ++N R + A+
Sbjct: 61 AKYCSSDQVEIFSSLLQRSMSLNIG-------------------GAKGSMN---RHVAAI 98
Query: 2394 GVRFRLLSCVLGMVQQDACLLRPTNVLIRQRVYSCAFHYFTIAPQGPTQPEERLREDIRL 2215
G RF+LL+ L ++ D ++R+++YS AF YF+ P+ PTQ E+RLREDI +
Sbjct: 99 GPRFKLLTLGLSLLHADVVPNATIRNVLREKIYSTAFDYFSCPPKFPTQGEKRLREDISI 158
Query: 2214 LTRFFEHLKNDKHYMQKEALAKTDKNLVMSSTMSQMQTNFEKSLLISXXXXXXXXXXXXX 2035
+ +F+ + +DK Y+ L D S+ + + + +
Sbjct: 159 MIKFWTAMFSDKKYLTASQLVPPDNQDTRSNLDITVGSRQQAT----------------- 201
Query: 2034 TSLMLPPSTNYANTLTLSSQKSMAATSASIRSGKSIETKLSIEEDRRIKTWMKQRNMLML 1855
+ NT LSS S + S +SG S +T + K +MK+R +L+
Sbjct: 202 --------QGWINTYPLSSGMS----TISKKSGMSKKTNRGSQLH---KYYMKRRTLLLS 246
Query: 1854 LVANEIERLSAWLHPLALAQEDCALDSEEFLRGAFTQAKATGGEKNIWREQAQLAWDISP 1675
L+A EIERL W +PL+ + + E + A ++K + W++ LAW ISP
Sbjct: 247 LLATEIERLITWYNPLSAPELELDQAGENSV--ANWRSKYISLSEKQWKDNVNLAWSISP 304
Query: 1674 ELAIQLPSRFRGSPELVKYVDVLVRGQPEPVAHIPEALPLFLGNGSTVFETSDMSHVLTW 1495
LA+QLP+RF+ + + V LVR P V+ +PEA+ + + + ++SHVL W
Sbjct: 305 YLAVQLPARFKNTEAIGNEVTRLVRLDPGAVSDVPEAIKFLVTWHTIDADAPELSHVLCW 364
Query: 1494 ARCSPVMALSLLTPRIYPMHPISMQYAVRVLRSYSADELLLYIPQIVQAVRYDTMGYISE 1315
A P LS + +YP HP++ QY V+VLRS+ D +L YIPQIVQA+RYD MGY+ E
Sbjct: 365 APTDPPTGLSYFSS-MYPPHPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYDKMGYVRE 423
Query: 1314 LIIWLAGHSQLLSHQLIWNMQTNMFTDEESKVKDPVLFEALNDIMQKILSQLEGAARRFH 1135
I+W A SQLL+HQ IWNM+TN++ DEE KDP + + L+ ++++I L G A+ F+
Sbjct: 424 YILWAASKSQLLAHQFIWNMKTNIYLDEEGHQKDPDIGDLLDQLVEEITGSLSGPAKDFY 483
Query: 1134 EAEFKLFHQLTAISGTIKPFPKGDARKKACLKALADVKIETITYLPSNPEAVLLDLDYSS 955
+ EF F+++T +S IKP+PKGD RKKACL AL++VK++ YLPSNPEA++LD+DY S
Sbjct: 484 QREFDFFNKITNVSAIIKPYPKGDERKKACLSALSEVKVQPGCYLPSNPEAIVLDIDYKS 543
Query: 954 GTPMQSAAKAPFLARFRVKRCGVRELEHIGLQAQSEHGGK--TTEADLEELKKVQDSRVC 781
GTPMQSAAKAP+LA+F+VKRCGV ELE GL+ +S+ + T EAD ++
Sbjct: 544 GTPMQSAAKAPYLAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEAD--------GQKIS 595
Query: 780 WQAAIFKVGDDVRXXXXXXXXXXXMKNVWAGLGLPVRVFPYRVVATSPGCGVIECVPNSK 601
WQAAIFKVGDD R KN++ +GL + VFPYRVVAT+PGCGVIEC+P+
Sbjct: 596 WQAAIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCT 655
Query: 600 SRDQLGRQTDFGLYEYFKTQYGDESSETFQEARRNFVRSMAAYSVFSFLLQIKDRHNGNI 421
SRDQLGRQTDFG+Y+YF QYGDES+ FQ+AR NF+RSMAAYS+ FLLQIKDRHNGNI
Sbjct: 656 SRDQLGRQTDFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNI 715
Query: 420 MIDLDGHIIHIDFGFMFESSPGGNLGFEPDFKLSEEMVAIMGGKMEAAPFRQFASLCVHA 241
M+D GHIIHIDFGFMFESSPGGNLG+EPD KL++EMV IMGGKMEA PF+ F +CV
Sbjct: 716 MLDKKGHIIHIDFGFMFESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVRG 775
Query: 240 YLAVRPYHKSFVSLVSLMLDTHLPCFRGKTINQLRARFAPEMNEKDAAKYMYSVITNCFL 61
YLAVRPY + VSLV+LMLDT LPCFRG+TI L+ RF+P M E++AA ++ VI +CFL
Sbjct: 776 YLAVRPYMDAVVSLVTLMLDTGLPCFRGQTIKLLKHRFSPNMTEREAANFIMKVIQSCFL 835
Query: 60 NIRSKMYDQLQYFQNEIPY 4
+ RS+ YD +QY+QN+IPY
Sbjct: 836 SNRSRTYDMIQYYQNDIPY 854