Motif confirmation by HMMer
hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file: /home/niguts/usr02/tshini/ykclst/db/Pfam_fs
Sequence file: hmm1/seq/C07H4.2
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Query: C07H4.2 CE27360 locus:clh-5 chloride channel protein status:Confirmed TR:Q17804 protein_id:CAA90949.2
Scores for sequence family classification (score includes all domains):
Model Description Score E-value N
-------- ----------- ----- ------- ---
voltage_CLC Voltage gated chloride channel 671.8 3.4e-198 1
CBS CBS domain 73.3 2.5e-18 2
NAD_binding_3 Homoserine dehydrogenase, NAD binding 5.5 2.6 1
Sterol_desat Sterol desaturase 3.4 3.7 1
Peptidase_C20 Type IV leader peptidase family 2.9 9.6 1
HAP Hydrophobic abundant protein (HAP) 2.4 7.2 1
Peptidase_S41B Peptidase family S41B 2.1 4.1 1
Parsed for domains:
Model Domain seq-f seq-t hmm-f hmm-t score E-value
-------- ------- ----- ----- ----- ----- ----- -------
Peptidase_S41B 1/1 279 291 .. 316 328 .. 2.1 4.1
NAD_binding_3 1/1 294 319 .. 114 139 .] 5.5 2.6
HAP 1/1 368 384 .. 1 17 [. 2.4 7.2
Peptidase_C20 1/1 368 391 .. 1 27 [. 2.9 9.6
Sterol_desat 1/1 368 403 .. 1 41 [. 3.4 3.7
voltage_CLC 1/1 203 597 .. 1 455 [] 671.8 3.4e-198
CBS 1/2 649 704 .. 1 54 [] 31.3 7.7e-07
CBS 2/2 740 792 .. 1 54 [] 43.0 4.8e-10
Alignments of top-scoring domains:
Peptidase_S41B: domain 1 of 1, from 279 to 291: score 2.1, E = 4.1
*->GdIfsFlFkKegL<-*
G Ifs+lF K+gL
C07H4.2 279 GNIFSYLFPKYGL 291
NAD_binding_3: domain 1 of 1, from 294 to 319: score 5.5, E = 2.6
*->ayyreLraaAeksgvdvyyEAaVggG<-*
a+ re+++a ++gv+v++ A+ gg+
C07H4.2 294 AKKREILSASAAAGVSVAFGAPIGGV 319
HAP: domain 1 of 1, from 368 to 384: score 2.4, E = 7.2
*->MMKYvFvALCLFavvvL<-*
MMK+ F+ L Fa+ L
C07H4.2 368 MMKWTFIELVPFAILGL 384
Peptidase_C20: domain 1 of 1, from 368 to 391: score 2.9, E = 9.6
*->mmLmdllqqyPwlflllafllGLivGS<-*
mm ++++++ P + +++l+G i+GS
C07H4.2 368 MMKWTFIELVP---FAILGLFGGIIGS 391
Sterol_desat: domain 1 of 1, from 368 to 403: score 3.4, E = 3.7
*->mvnnlletfllfwafyllllilylirclpyfitdfipYssk<-*
m ++++ ++f +l l+ ++i + +fi+++i++s++
C07H4.2 368 MMKWTFIELVPFA---ILGLFGGIIGS--LFIFANIRWSRF 403
voltage_CLC: domain 1 of 1, from 203 to 597: score 671.8, E = 3.4e-198
*->fslvlvllaalLvkkfaPaAaGSGIPEiKtiLnGikivdgkgylrlr
+++++ +la+l+vk+faP+A+GSGIPEiK+iL+G++i +gyl+++
C07H4.2 203 WAVAMSTLAVLFVKIFAPYACGSGIPEIKCILSGFVI---RGYLGKW 246
tllvKvvGlalsigsGLslGKEGPfVHiGaciaalLskggStslrlqfsl
t+++K+vGl+ls +sGLslGKEGP+VH+++ci++++s++ +
C07H4.2 247 TFIIKSVGLILSSASGLSLGKEGPMVHLACCIGNIFSYL----------F 286
fkyseedrRkdrRdLlaaGaAaGvAaAFgAPiGGVLFslEevssenarfn
+ky ++++ ++R++l+a+aAaGv++AFgAPiGGVLFslEe+s+ +f+
C07H4.2 287 PKYGLNEA--KKREILSASAAAGVSVAFGAPIGGVLFSLEEASY---YFP 331
vkllwrsLFFasavaafvlrlinsffvsgkcgdFgtglalFdvsfrtdrf
+k++wrs FF+++va ++lr++n+f+ + ++ lF+v ++++
C07H4.2 332 LKTMWRS-FFCALVAGIILRFVNPFGS-------N-QTSLFHVDYMMK-- 370
pwtlfElplFillGifgGllGalFnrlnrkilkfrkKnrylskklkkppv
wt+ El +F++lG fgG++G+lF+++n+++++frk + +++ + +p+
C07H4.2 371 -WTFIELVPFAILGLFGGIIGSLFIFANIRWSRFRK--NSKML--GGNPI 415
levalvglltavlsfplplllgcagglelveegrtlnilfdnCtwgeynd
+ev+l++l+ta++s+++p++++ + +++++ +lfd+C++ ++
C07H4.2 416 YEVMLITLVTAAISYFNPFTRK--SAQSMIQ------QLFDRCED---QI 454
lasllcntpedavlslFhwnipgegdffaftlLlllliakflltlltfGi
++++lc+ ++ ++af++Ll++li+kf++t++tfGi
C07H4.2 455 DEDSLCDQNK--------------ALSIAFGQLLWALIFKFVITIFTFGI 490
gvPgGlFvPslaiGAalGrlvGiaverlimavls...H.dwfpfgifceg
+vP+GlFvPs+ +GA+ Gr++Gi+v+++++av+++++H+d+ c+
C07H4.2 491 KVPCGLFVPSIGMGAIAGRILGITVDQIFRAVQAtpgHsDY----FTCQI 536
fpdcilePGlYAvlGAAAflGGvvrmTvslaVImfElTGnlsvilPlmvA
++dc++ PGlYA++GAAA+lGGv+rmTvsl+VImfElTG+l++i+P+mvA
C07H4.2 537 GKDCVM-PGLYAMVGAAAVLGGVTRMTVSLVVIMFELTGSLEFIVPTMVA 585
vliaklvadslg<-*
++ +k+++d ++
C07H4.2 586 TMFSKWIGDGIS 597
CBS: domain 1 of 2, from 649 to 704: score 31.3, E = 7.7e-07
*->dimtrdvvtvspdttleealelmrengisrlPVvded..gklvGivt
+ ++ v ++tl ++ l+r+++++++PVv +++ +lvG +t
C07H4.2 649 ELKNELSVITESGMTLGDLESLLRQTDFNGFPVVVSQnsMHLVGFIT 695
lrDllralv<-*
+rD+l al
C07H4.2 696 RRDILLALH 704
CBS: domain 2 of 2, from 740 to 792: score 43.0, E = 4.8e-10
*->dimtrdvvtvspdttleealelmrengisrlPVvdedgklvGivtlr
i + tv+ t+ e +++++r+ g+++++V+++ gk++Gi+t++
C07H4.2 740 KILDMAPMTVTDQTPMETVIDMFRKLGLRHVLVTKN-GKVLGIITKK 785
Dllralv<-*
D+l +++
C07H4.2 786 DILQFMR 792