Motif confirmation by HMMer
hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
HMM file: /home/niguts/usr02/tshini/ykclst/db/Pfam_fs
Sequence file: hmm2/seq/F10G7.2
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: F10G7.2 CE02626 human 100 kDa activator protein status:Partially_confirmed TR:Q19328 protein_id:AAA81130.1
Scores for sequence family classification (score includes all domains):
Model Description Score E-value N
-------- ----------- ----- ------- ---
SNase Staphylococcal nuclease homologue 312.7 4.3e-90 5
TUDOR Tudor domain 115.4 1e-30 1
OpuAC Substrate binding domain of ABC-type glycine 3.4 8.3 1
Parsed for domains:
Model Domain seq-f seq-t hmm-f hmm-t score E-value
-------- ------- ----- ----- ----- ----- ----- -------
SNase 1/5 22 168 .. 1 158 [] 22.1 8.3e-05
SNase 2/5 193 328 .. 1 158 [] 59.5 3.9e-15
OpuAC 1/1 437 452 .. 1 16 [. 3.4 8.3
SNase 3/5 341 492 .. 1 158 [] 25.6 9.1e-06
SNase 4/5 524 668 .. 1 158 [] 187.4 2.2e-52
TUDOR 1/1 687 809 .. 1 124 [] 115.4 1e-30
SNase 5/5 850 906 .. 97 158 .] 18.2 0.001
Alignments of top-scoring domains:
SNase: domain 1 of 5, from 22 to 168: score 22.1, E = 8.3e-05
*->kkipgkVvRVvDGSDTiivlpkggg...ktirvRLvGIDaPEtahpk
+ +g V V++G D +i+ + +++++++v L+++ aP+ +++
F10G7.2 22 AVRRGLVKSVLSG-DAVILQGQPHNgppPEWTVYLSNVTAPRLGRRP 67
kgdgeyklitdiepvqpFGkeAkeflkklvlgkkvvvlefdkrkDkYGRl
+ +++ p +p++ +++e+l+ +++g+ v+ +++ + GR
F10G7.2 68 TDSASAT------PDEPYAWDSREYLRQKLVGQFVTFVRDFT--ATSGRD 109
LayVylnpsrn.rtpqgkniNeeLVKeGLAwvyegfyppdndkhddella
+++yl+ ++ + + +n+ e V +GL ++ + ++ d++ +ll+
F10G7.2 110 HGRIYLG---GtSPADAENVAEGAVSAGLLE-VR-QGKV-ADEYSTKLLE 153
aEeeAkkkrkGLWsd<-*
++e+Ak++++G W++
F10G7.2 154 LQEQAKSAGRGKWNS 168
SNase: domain 2 of 5, from 193 to 328: score 59.5, E = 3.9e-15
*->kkipgkVvRVvDGSDTiivlpkgggktirvRLvGIDaPEtahpkkgd
k i+ + + V DG T++ ++ + i++ L+G++aP t++p+
F10G7.2 193 KPIDAVIEMVRDG-STVRAFLLPNFEYITLQLSGVRAPSTRNPNA-- 236
geyklitdiepvqpFGkeAkeflkklvlgkkvvvlefdkrkDkYGRlLay
++ +++F +eAk f++ ++l+++v+++ +++ ++++++
F10G7.2 237 AD-------SRAEAFSEEAKFFAESRLLQRDVQIILEST---SNQNFVGS 276
VylnpsrnrtpqgkniNeeLVKeGLAwvyegfyppdndkhddellaaEee
+ + ni e L++eG+A + ++ +++ ++l+ aE++
F10G7.2 277 IVHP--------KGNIAESLLREGYAKCVDWSIGL-CTGGAQKLRDAERQ 317
AkkkrkGLWsd<-*
Ak+kr+ LW++
F10G7.2 318 AKEKRLRLWKS 328
OpuAC: domain 1 of 1, from 437 to 452: score 3.4, E = 8.3
*->ktVvigsknwtEgqil<-*
+t++ig++n++Eg i+
F10G7.2 437 ATIKIGDQNIAEGLIS 452
SNase: domain 3 of 5, from 341 to 492: score 25.6, E = 9.1e-06
*->kkipgkVvRVvDGSDTiivlpkgggktirvRLvGIDaPEtahpkkgd
k ++gkVv +v D + v +++g ++++ L+ I+ P+ + gd
F10G7.2 341 KAFTGKVVEIVLS-DAVVVQKDDG-SEVKLHLSSIRLPRES----GD 381
geykl..itdiepv..qpFGkeAkeflkklvlgkkvvvlefdk...rkDk
+ +++ +p+ + pF A+efl+k++lgkkv++ ++ ++++++
F10G7.2 382 DKATGgpGRQFRPLydIPFMFQAREFLRKRLLGKKVQIQIDYVqpkSENF 431
YGRlLayVylnpsrnrtpqgkniNeeLVKeGLAwvyegfyppd.ndkhdd
+ + a++ ++ +ni e L+ GL v++++ ++++++ ++d
F10G7.2 432 PEKTCATIKIG--------DQNIAEGLISRGLSKVVRHRADDEnRSSEYD 473
ellaaEeeAkkkrkGLWsd<-*
llaaE++A k +kGL +d
F10G7.2 474 TLLAAEANAEKGKKGLFAD 492
SNase: domain 4 of 5, from 524 to 668: score 187.4, E = 2.2e-52
*->kkipgkVvRVvDGSDTiivlpkgggktirvRLvGIDaPEtahpkkgd
++++g+V++ + GS+ +i++pk++ +i++ L GI++P+ a++++g+
F10G7.2 524 GRAEGVVEFLSGGSRLRIYIPKET-VLITFLLGGINCPKGARVGPGG 569
geyklitdiepvqpFGkeAkeflkklvlgkkvvvlefdkrkDkYGRlLay
++++ +++pF++eA +f++klvl+++v+++++++ Dk+G++++y
F10G7.2 570 VSTG------AAEPFADEAAAFTRKLVLQHEVQLEVEST--DKNGNFVGY 611
VylnpsrnrtpqgkniNeeLVKeGLAwvyegfyppdndkhddellaaEee
+y+ p++n t++ +n++e+LV++GLA+++++++++ +h++ ll aE++
F10G7.2 612 LYVSPDGN-TSRAINLSEALVENGLASLHFTAERS---GHYNALLSAENK 657
AkkkrkGLWsd<-*
Akk++k++W++
F10G7.2 658 AKKAKKNIWAN 668
TUDOR: domain 1 of 1, from 687 to 809: score 115.4, E = 1e-30
*->epegstvdvvvshie.spgeFyvqqpksdskkleklmeelqeyyssk
e+++++ +v v++i+++ +F + q+++d +k+ek+++e+++ +++
F10G7.2 687 ERKQNFRQVAVTDIApGALRFSA-QNIEDGPKIEKMTTEMRQALAEH 732
ppvaelptp.vgdgcvavfseDgkWyRAritvelddelveVffvDyGnte
pp a+++t ++gd cva+fs Dg+WyR+++ ++++++++e+ ++DyGn+e
F10G7.2 733 PPLAGSYTTkRGDLCVAKFSQDGQWYRCKV-ESVRAGQAEIVYIDYGNRE 781
tvplsdlrplpppefalLPpqaikcrLag<-*
t+++ +l ++p fa+ P + + La
F10G7.2 782 TIEAVKLAQIP-AGFANFPAGVREYNLAL 809
SNase: domain 5 of 5, from 850 to 906: score 18.2, E = 0.001
*->yVylnpsrnrtpqgkniNeeLVKeGLAwvyegfyppdndkhddella
+Vy++ s+n + +i + L+ eGLA + ++++p + +++
F10G7.2 850 TVYYD-SGN---KKVDIGKSLIAEGLAL-ADHRREPRLQTLVNDYNT 891
aEeeAkkkrkGLWsd<-*
Ee A+k rk++W +
F10G7.2 892 TEEVARKSRKNIWEY 906