Motif confirmation by HMMer
hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file: /home/niguts/usr02/tshini/ykclst/db/Pfam_fs
Sequence file: hmm3/seq/F44D12.1
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Query: F44D12.1 CE05865 Tight junction protein like status:Partially_confirmed TR:Q20398 protein_id:CAA92607.1
Scores for sequence family classification (score includes all domains):
Model Description Score E-value N
-------- ----------- ----- ------- ---
PDZ PDZ domain (Also known as DHR or GLGF) 38.7 1.5e-09 3
Guanylate_kin Guanylate kinase 8.3 0.98 1
DUF47 Protein of unknown function DUF47 3.7 8 1
Focal_AT Focal adhesion targeting region 3.3 4 1
PARP Poly(ADP-ribose) polymerase catalytic d 3.1 7.7 1
HCV_NS1 Hepatitis C virus non-structural protei 0.8 8.3 1
Parsed for domains:
Model Domain seq-f seq-t hmm-f hmm-t score E-value
-------- ------- ----- ----- ----- ----- ----- -------
DUF47 1/1 28 46 .. 160 178 .. 3.7 8
PARP 1/1 96 121 .. 1 30 [. 3.1 7.7
PDZ 1/3 184 267 .. 1 84 [] 32.6 8.2e-08
PDZ 2/3 275 311 .. 1 46 [. 4.0 12
Focal_AT 1/1 383 392 .. 1 11 [. 3.3 4
HCV_NS1 1/1 515 556 .. 75 117 .. 0.8 8.3
PDZ 3/3 701 719 .. 45 63 .. 2.0 45
Guanylate_kin 1/1 911 971 .. 47 108 .] 8.3 0.98
Alignments of top-scoring domains:
DUF47: domain 1 of 1, from 28 to 46: score 3.7, E = 8
*->keieelEdeiDqlqrkllk<-*
k+i+e+E++iD+lq++ ++
F44D12.1 28 KKIDEFEEKIDSLQIQVHR 46
PARP: domain 1 of 1, from 96 to 121: score 3.1, E = 7.7
*->LktkLepvdkdseGkiGEfsilrqYvkNth<-*
L+ ++e + +dse E+ +l+q +Nt+
F44D12.1 96 LQKEIEKMKEDSE----EVAALKQKLENTR 121
PDZ: domain 1 of 3, from 184 to 267: score 32.6, E = 8.2e-08
*->evtlekevkrgglGfsikggsdk.......givvsevlpGsgaAeag
++ l+ lG+++ gg ++++ +++i+v + +G ++ +
F44D12.1 184 QINLPF--NKPNLGIMLGGGRTDdgsivhgPIYVRQIAHG-SPFDNV 227
GrLkeGDvIlsvNGqdvenmsheravlaikgsggsevtLtvlRd<-*
Lk+ D I+ vN+ +v++m + ++ ++ +++ +++L+++R+
F44D12.1 228 --LKKLDHIMMVNDISVTDMDERSVMGMLSNCH--HIHLVIRRR 267
PDZ: domain 2 of 3, from 275 to 311: score 4.0, E = 12
*->evtlekevkrgglGfsikggsdkgivvsevlpGsgaAeagGrLkeG<
+v l+ + g+G++++ g+++++ p+ gaA ++G L +G
F44D12.1 275 DVCLP---LNYGVGLELSN----GVFINSCEPN-GAASRSG-LAPG 311
-*
F44D12.1 - -
Focal_AT: domain 1 of 1, from 383 to 392: score 3.3, E = 4
*->tanldRadDeV<-*
an dR++D+V
F44D12.1 383 -ANIDRSNDQV 392
HCV_NS1: domain 1 of 1, from 515 to 556: score 0.8, E = 8.3
*->rsiddFrqGWGpleyeenvtneeDqRPYCWHYpPrpCgivpAk<-*
++i r GW ++ t +D RPY H+ P +i+ k
F44D12.1 515 SQISSHRGGWDGRSFSS-NTTTSDARPYSMHFTPTSSTIMEGK 556
PDZ: domain 3 of 3, from 701 to 719: score 2.0, E = 45
*->eGDvIlsvNGqdvenmshe<-*
eGD Ils++G v+n ++e
F44D12.1 701 EGDLILSIDGNCVRNTTLE 719
Guanylate_kin: domain 1 of 1, from 911 to 971: score 8.3, E = 0.98
*->sletvrqvakqgKiciLDvepQgvkrlrtaelsNPivvFIaPpSlqe
s++ + + +qg +c+L v+ +++rl+ Pi+v I+ +S++
F44D12.1 911 STAHIMDITAQGLHCVLQVDQSAIDRLKRCRMF-PILVKIRFKSVKQ 956
lekrLegrnkesEes<-*
l+++ e ++ e s
F44D12.1 957 LKDVNEHICGEKISS 971