Motif confirmation by HMMer


hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
HMM file:                 /home/niguts/usr02/tshini/ykclst/db/Pfam_fs
Sequence file:            hmm3/seq/K09B11.5
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query:  K09B11.5  CE19992   Eukaryotic protein kinase domain status:Partially_confirmed TR:Q9U3B5 protein_id:CAB63235.1

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N
-------- -----------                                    -----    ------- ---
pkinase  Protein kinase domain                          194.8    1.3e-54   1
SH2      SH2 domain                                      10.6      0.022   1
XPG_N    XPG N-terminal domain                           10.3       0.14   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
SH2        1/1      76   131 ..     1    59 [.    10.6    0.022
pkinase    1/1     181   439 ..     1   294 []   194.8  1.3e-54
XPG_N      1/1     448   469 ..    89   111 .]    10.3     0.14

Alignments of top-scoring domains:
SH2: domain 1 of 1, from 76 to 131: score 10.6, E = 0.022
                   *->WyhGkIsRkeAErlLlnpggkdGtFLvReSestpGd...YtLSVrdd
                      WyhG + ++ +E+lL+     d ++LvR    + ++++   LSV+ d
    K09B11.5    76    WYHGMMFGQTVEKLLKW----DYAYLVRRAM-QRNSkkvLCLSVKID 117

                   gprVkHyrIqsldng<-*
                   g ++ H+  +s+++g
    K09B11.5   118 G-KICHFTLNSNKDG    131

pkinase: domain 1 of 1, from 181 to 439: score 194.8, E = 1.3e-54
                   *->yelleklGeGsfGkVykakhkd...ktgkiVAvKilkk..ekesike
                      ++l  +lG G+fG+V ka+++++++ +g +VAvK +  + ++e+++e
    K09B11.5   181    IHLENILGNGAFGEVLKARYIPrghTNGVEVAVKRVIGtaQREQMQE 227

                   krflrEiqilkrLsHpNIvrligvfedtddhlylvmEymegGdLfdylrr
                     f  E+qi+ +L+H+N+v+l+g+    +++++lvmE+  gGdL++yl++
    K09B11.5   228 --FCHEAQIMGTLKHDNVVKLYGIAS-LEQPIMLVMELITGGDLKKYLQS 274

                   nggplsekeakkialQilrGleYLHsngivHRDLKpeNILldendgtvKi
                       ++ ++++ +al+i++G+ +L  ++++HRDL+++N+L+++++ +vKi
    K09B11.5   275 TP-SIPNRQLIAFALDIANGMRHLVIKKVIHRDLAARNCLISRPTLQVKI 323

                   aDFGLArllesssklttfvGTpwYmmAPEvilegrgysskvDvWSlGviL
                   +DFGLA +    +  + +   p++++APE   +   +  k DvWS+Gv+L
    K09B11.5   324 SDFGLAVQAT-EVIVKKLSKAPTRWLAPET-FQKGIFNEKTDVWSFGVVL 371

                   yElltggplfpgadlpaftggdevdqliifvlklPfsdelpktridplee
                    E+lt+              ++            P          ++lee
    K09B11.5   372 TEILTR--------------CA----------ADPLAP-------RTLEE 390

                   lfriikrpglrlplpsncSee.lkdLlkkcLnkDPskRpGsatakeilnh
                     + i +  +++ + +n  + +l +L++ c++k+   R    +++ ++ +
    K09B11.5   391 CKKYIIE-SPHPHRIENKEPKeLAELVEMCCDKNTMCRA---NFQNAKRR 436

                   pwf<-*
                   + +
    K09B11.5   437 LKI    439

XPG_N: domain 1 of 1, from 448 to 469: score 10.3, E = 0.14
                   *->DGgapndlKaetlqKRsarrqea<-*
                      DG ++  lK++++qKR  +r ++
    K09B11.5   448    DGHKL-ELKKSEEQKRLTIRRST    469



[DB home][top]