Motif confirmation by HMMer
hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file: /home/niguts/usr02/tshini/ykclst/db/Pfam_fs
Sequence file: hmm4/seq/M176.7
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Query: M176.7 CE12472 locus:kin-16 tyrosine-protein kinase (KIN15\/KIN16 subfamily) (2 domains) status:Partially_confirmed SW:P34892 prot
Scores for sequence family classification (score includes all domains):
Model Description Score E-value N
-------- ----------- ----- ------- ---
pkinase Protein kinase domain 197.3 2.4e-55 1
Kelch Kelch motif 5.5 6.2 1
Parsed for domains:
Model Domain seq-f seq-t hmm-f hmm-t score E-value
-------- ------- ----- ----- ----- ----- ----- -------
Kelch 1/1 427 444 .. 28 45 .] 5.5 6.2
pkinase 1/1 140 454 .. 1 294 [] 197.3 2.4e-55
Alignments of top-scoring domains:
Kelch: domain 1 of 1, from 427 to 444: score 5.5, E = 6.2
*->vevYDpetntWeklpsmp<-*
ve YD+++ +W++ p+++
M176.7 427 VELYDLMKLCWHEKPELR 444
pkinase: domain 1 of 1, from 140 to 454: score 197.3, E = 2.4e-55
*->yelleklGeGsfGkVykakhkd.........ktgkiVAvKilkk..e
+e + +lG+G+fG+V+k+++k+ ++++++++k +VAvK + +
M176.7 140 LENKSILGSGNFGVVRKGILKMaspkneeekKMRLTVAVKSAANcyD 186
kesikekrflrEiqilkrLs.HpNIvrligvfed..tddhlylvmEymeg
++++ + +E++++ ++ + pN++ l g+++ + ++++l +v+Ey ++
M176.7 187 ISQTSM--LAAELRLMCSIGrFPNVLALVGAVTSelRKGRLLIVTEYIDC 234
GdLfdylrrng.......................................
Gd ++yl ++++ +++ ++++++++ ++ + ++++ ++++++++
M176.7 235 GDIRKYLIDHRnvfqdhliedktepdsyltpisakrknyvfkntdensdy 284
......gplsekeakkialQilrGleYLHsngivHRDLKpeNILldendg
+++ + l+ +++++ lQi++G++YL s vHRDL+ +N+Ll++n
M176.7 285 vikeslDSLTTSDLLSFGLQIANGMQYLASIPMVHRDLALRNVLLKKN-K 333
tvKiaDFGLArlle.....sssklttfvGTpwYmmAPEvilegrgysskv
t++iaDFG+Ar e+++ +k+++ ++m +PE +++ k+
M176.7 334 TIRIADFGMARTHEnksyyIPQKTKDAPVPVRWM-SPEA-FDTMKFTEKS 381
DvWSlGviLyElltggplfpgadlpaftggdevdqliifvlklPfsdelp
DvWS+G+ LyE++t g +lP++d
M176.7 382 DVWSFGICLYEIFTLG-------------------------QLPYPD--- 403
ktridpleelfriikrpglrlplpsncSeelkdLlkkcLnkDPskRpGsa
p e++++ g+r p+p++c el+dL+k c++ P+ Rp
M176.7 404 ----VPSERIYEYMHS-GRRCPQPQHCHVELYDLMKLCWHEKPELRP--- 445
takeilnhpwf<-*
++ + +f
M176.7 446 NFSNC--VEYF 454