Motif confirmation by HMMer
hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file: /home/niguts/usr02/tshini/ykclst/db/Pfam_fs
Sequence file: hmm4/seq/T03D8.5
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Query: T03D8.5 CE18923 locus:gcy-22 Natriuretic peptides receptors, guanylate cyclase status:Partially_confirmed TR:Q9XTY1 protein_id:CAB0741
Scores for sequence family classification (score includes all domains):
Model Description Score E-value N
-------- ----------- ----- ------- ---
guanylate_cyc Adenylate and Guanylate cyclase catalyt 298.6 7.7e-86 1
ANF_receptor Receptor family ligand binding region 99.8 1.4e-26 2
pkinase Protein kinase domain 34.0 2.4e-08 2
DUF342 Protein of unknown function (DUF342) 2.1 7.3 1
Parsed for domains:
Model Domain seq-f seq-t hmm-f hmm-t score E-value
-------- ------- ----- ----- ----- ----- ----- -------
ANF_receptor 1/2 79 174 .. 58 159 .. 49.4 1.2e-12
DUF342 1/1 197 208 .. 1 12 [. 2.1 7.3
ANF_receptor 2/2 184 363 .. 216 446 .. 50.3 6.7e-13
pkinase 1/2 537 601 .. 52 117 .. 1.8 21
pkinase 2/2 649 743 .. 169 289 .. 32.2 7.6e-08
guanylate_cyc 1/1 812 999 .. 1 226 [] 298.6 7.7e-86
Alignments of top-scoring domains:
ANF_receptor: domain 1 of 2, from 79 to 174: score 49.4, E = 1.2e-12
*->dsacdcsfavavavdlllekgvdewvvAiIGPscssaaiavarlane
++ c + +av+ e +++ +++GP+c a +++++a++
T03D8.5 79 TN-CREADAVGSVINYA-EGHAH----VVLGPPCVRPAQVAGSVAKY 119
wniPlisygatapelsdketrfptflRTlPsdtkqgealvdllkhfgWtw
++ Pli +g + ++ + ++pt++ T+ s+ +q+ +l++ll++++Wt+
T03D8.5 120 LDFPLILWGPPFDSSLLNQFEYPTIASTTSSTLYQATSLIRLLEYYKWTE 169
valvy<-*
+al+y
T03D8.5 170 IALIY 174
DUF342: domain 1 of 1, from 197 to 208: score 2.1, E = 7.3
*->vkleVeisedeM<-*
++l+++ise+ M
T03D8.5 197 RNLMISISENGM 208
ANF_receptor: domain 2 of 2, from 184 to 363: score 50.3, E = 6.7e-13
*->RvivvcgsSVLiGgedlrqlleqavrlGmtgggyvfisedwlsssld
R+++vc +S e r+l++++ + Gm g++yv+i+++ ++
T03D8.5 184 RFVIVCLES----DEARRNLMISISENGMDGDEYVYIMAESRRAGFA 226
ldpdlellapgaitlgtdgsdnvlgfayyavlvitldspdnpefnefwee
++ + + dg + + +a++ +lv + + +f++e
T03D8.5 227 SS-F------WNG--T-DGKNDLALRAARKFLVMDNQKYND--TTTFVQE 264
lfecaltpfnfnksesdrkCtgvecnsqalledtsvnpyagavyDaVyly
++++ +p+ + Ct+ + ++ +g + Da +ly
T03D8.5 265 VRAAFSRPPFS-----CPNCTNI--D----PTVSQ----VGPLGDALLLY 299
AhAlhnellrngggctlcaasdwrdGsqllrylrnvtFeGltGpeVqfDe
A+Al n ++ g+ + G+++ + +++ F G+tG V +++
T03D8.5 300 AYAL-NRSIATGN--------PNPTGTEFCEVAKGMEFLGFTGK-VIINQ 339
nRGDrnpdYdllnlqdsetgklevvgSGmPitfy<-*
n r p ++++nl +t+k +v+ +
T03D8.5 340 N-STRTPLFVVYNL--DSTDKEMIVM-------Q 363
pkinase: domain 1 of 2, from 537 to 601: score 1.8, E = 21
*->lkrLsHpNIvrligvfedtddhlylvmEymegGdLfdylrrnggpls
+++++ +N++++ig +++ l + y+ G+L d++ + +++
T03D8.5 537 MRNVDNDNLCKFIGLSL-DSPTLISIWRYCSRGSLQDVIAKGSLQMD 582
ekeakkialQilrGleYLH<-*
+ +++++++ ++ YLH
T03D8.5 583 WFFKYSLMRDVADAIYYLH 601
pkinase: domain 2 of 2, from 649 to 743: score 32.2, E = 7.6e-08
*->APEvileg..rgysskvDvWSlGviLyElltggplfpgadlpaftgg
APE +++++ +++++ D++S+ +i+ El t+
T03D8.5 649 APEH-IRDtnLPITKEMDIYSFAIICSELITK--------------- 679
devdqliifvlklPfsdelpktridpleelfriikrpglrlplpsncSee
k+ ++ ++ + +eel++ ik+ g+r+p+ +++ e
T03D8.5 680 -----------KSAWDL---ENETFDIEELVYKIKK-GGRSPPRPSLETE 714
......lkdLlkkcLnkDPskRpGsatakeil<-*
+++++++ L+++c+n +P +Rp t ++i+
T03D8.5 715 dehngsMSLLVRDCWNENPDQRP---TSEQIK 743
guanylate_cyc: domain 1 of 1, from 812 to 999: score 298.6, E = 7.7e-86
*->vyaerydeVtilFaDIvgFTalssrhssNngPeevvrlLNelftrFD
v++e +d+Vti+F+D+v FT+l+sr++ P +vv+lLN+l+t+FD
T03D8.5 812 VEPETFDCVTIFFSDVVSFTTLASRCT----PLQVVNLLNDLYTTFD 854
elvdehkfgvyKiKTiGDaYMaasGlppaakakqtssKlaeeldedsaaH
++++h +vyK++TiGD+Y+++sGlp ++ + +H
T03D8.5 855 AIIEQH--DVYKVETIGDGYLCVSGLPHRN----------------GNEH 886
aakladfALamvealqevnvghteggpPlvLyrglqlRiGIHtGpVvaGv
a + ++ ++ a+++++v+h++ ++ +++R+G+HtGpVv Gv
T03D8.5 887 AKEISSMSFSLLKAIKTFRVPHLPKER-------INIRVGLHTGPVVTGV 929
iGgaskrprYdvwGdTVNvASRmEStGvpgekIhVsestyrlLkelesfq
+G + +prY+++Gd VN+ASRmES+G+pg ++h+s + + L+e +
T03D8.5 930 VG--MTMPRYCLFGDSVNTASRMESNGKPG-RVHISTECMKFLTEVIG-G 975
fefaleprgevsvkGkgkpGaietYfLkg<-*
+++ eprgev vkGk Ga++t++L
T03D8.5 976 YQT--EPRGEVIVKGK---GAVQTHWLLT 999