Motif confirmation by HMMer
hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file: /home/niguts/usr02/tshini/ykclst/db/Pfam_fs
Sequence file: hmm4/seq/T07H6.1a
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Query: T07H6.1a CE30449 esterase status:Partially_confirmed TR:Q95ZP3 protein_id:AAK77632.2
Scores for sequence family classification (score includes all domains):
Model Description Score E-value N
-------- ----------- ----- ------- ---
COesterase Carboxylesterase 354.3 1.3e-102 3
Clusterin Clusterin 5.8 0.46 1
COX2_TM Cytochrome C oxidase subunit II, transmemb 4.5 7.9 1
Parsed for domains:
Model Domain seq-f seq-t hmm-f hmm-t score E-value
-------- ------- ----- ----- ----- ----- ----- -------
Clusterin 1/1 1 20 [. 1 20 [. 5.8 0.46
COesterase 1/3 1 255 [. 1 277 [. 301.4 1.1e-86
COesterase 2/3 357 498 .. 339 483 .. 22.9 7.5e-06
COX2_TM 1/1 566 585 .. 41 60 .. 4.5 7.9
COesterase 3/3 531 619 .. 500 592 .] 30.0 7.1e-08
Alignments of top-scoring domains:
Clusterin: domain 1 of 1, from 1 to 20: score 5.8, E = 0.46
*->mktLLllvgLlLvwesGqVL<-*
m+ LLll+ +w +Gq L
T07H6.1a 1 MRELLLLLTFIFSWANGQLL 20
COesterase: domain 1 of 3, from 1 to 255: score 301.4, E = 1.1e-86
*->mglllllllllllllavvataptspedpvVeTsyvgGkvrGlrvkvd
m lllll++ +++ ++ ++ V ++ G vrG++++ d
T07H6.1a 1 MRELLLLLTFIFSWANGQLLEKSR----SVWVEQ--GLVRGNIYNID 41
ggnkpvyaFlGIPYAkPPvGeLRFkkPqPipepWtgvldATkygpaCpQn
g k++ F+G+PYA+PP+GeLRFk+P+ + W++ l A +ygp C+Q
T07H6.1a 42 G--KHIQIFRGVPYAEPPIGELRFKPPVK-KTRWHQELPAVEYGPPCLQF 88
dlgfpgfpLAlevmgsemwnkntg......vsmSEDCLYLNVytPklase
+ +f+ kn +++ +SEDCLYLNV++P ++++
T07H6.1a 89 M----DFH------------KNDKfaktnmDRQSEDCLYLNVFSPYDTDD 122
nk.klPVmVwIHGGGFqsGsassfslddydgpdlaaekdVVVVtiNYRLG
+++ +P +VwIHGG F Gsa d++ ++ ++k++ +V+iNYRLG
T07H6.1a 123 ESkTYPILVWIHGGSFLAGSA-DTGIDMEVIAANIVSKGIAFVSINYRLG 171
alGFL.stgdselpvppGNaGLlDQvlALrWVqeNIaaFGGDPdnVTlFG
+lGF+++ ++++l GN+G++D+v+AL+W+q NI+ F+GDP +VT++G
T07H6.1a 172 PLGFMnYQNGDKLE---GNFGIWDMVMALQWIQSNIKQFNGDPTKVTVMG 218
eSAGAaSVsllllSppqsrgLFhrAIlqSGsalspwai<-*
eSAG+a+ sll lS p + gL h+AI++SGs+++ wai
T07H6.1a 219 ESAGGAASSLLALS-PKTSGLLHQAIIMSGSSMAGWAI 255
COesterase: domain 2 of 3, from 357 to 498: score 22.9, E = 7.5e-06
*->vvdGdtpdaflpkdPeellkegnfnkvPlliGvtsdEGllflayll.
vvdGd ++p + l ++ +++P+++Gv + E ++ a++++
T07H6.1a 357 VVDGD----LVPSSGVSLVRN--NARIPIMTGVARKEWGHKKAMFYn 397
dp.esadllslldnedlflellpellpgaselltpklreeiadalkeeYt
+ ++ ++s++ + ++ + + + +ase+l + + ia+a + +Y+
T07H6.1a 398 MHqRDGLKRSDVEEQV-YRIIDNSFHETASEKLANSTVQLIANATIVRYL 446
dd.dd.nseesr.ealvdllsDylFvcpilrlaaarlakggapvYlYrFd
+ ++ ++ ++ + al++l sD+ Fv+p +a + + g+pvYlY+Fd
T07H6.1a 447 ETpNNeFIADQVvGALQKLESDIEFVAP-CEREVAAYVDKGVPVYLYSFD 495
yrs<-*
y++
T07H6.1a 496 YVP 498
COX2_TM: domain 1 of 1, from 566 to 585: score 4.5, E = 7.9
*->ilvsllfnFnrrkskltnry<-*
il+++l+nF+ ++++ t r+
T07H6.1a 566 ILCTMLTNFVKNGDPSTTRF 585
COesterase: domain 3 of 3, from 531 to 619: score 30.0, E = 7.1e-08
*->mgvsHgdelsYvFGnpls.kly....teeeeklssrrmmrywtnFAk
+++ Hg + ++F ++s+++ ++ t++ee++s +++ +++tnF+k
T07H6.1a 531 KAAFHGLDHAFIFSKGYSsNFEispyTKREETMS-KILCTMLTNFVK 576
tGnPNngessglpkWppytseeqkYyllntlltistk.lreedprkvkca
+G+P s++ Wp +++++ +Y l l+ +++ d +
T07H6.1a 577 NGDP----STTRFSWPIFSGNSSQYVSLDVPLKLLEGeIHFPD-----AQ 617
fw<-*
fw
T07H6.1a 618 FW 619