Motif confirmation by HMMer


hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /home/niguts/usr02/tshini/ykclst/db/Pfam_fs
Sequence file:            hmm4/seq/T28D9.7
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Query:  T28D9.7  CE28095   degenerin status:Partially_confirmed SW:Q10025 protein_id:AAA68309.2

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N
-------- -----------                                    -----    ------- ---
ASC      Amiloride-sensitive sodium channel             489.7   2.3e-143   1
GED      Dynamin GTPase effector domain                   5.8        2.3   1
PI3K_C2  C2 domain                                        5.5          2   1
SNase    Staphylococcal nuclease homologue                4.1        7.6   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
PI3K_C2    1/1     453   504 ..   144   205 .]     5.5        2
GED        1/1     567   606 ..    60    97 .]     5.8      2.3
ASC        1/1      26   685 ..    19   622 .]   489.7 2.3e-143
SNase      1/1     763   771 ..   150   158 .]     4.1      7.6

Alignments of top-scoring domains:
PI3K_C2: domain 1 of 1, from 453 to 504: score 5.5, E = 2
                   *->sltWpskepdesvptsTPGKvplesrdelnrLekllkkyerGdvqpn
                      +l W +  pd +++t       ++  ++++r+++l+++ye ++ q+
     T28D9.7   453    KL-WHVFMPDSYIRT------MTGDFSRMDRIIELMNQYELNKLQR- 491

                   pvvdwlDfltlreie<-*
                       w  ++++r ++
     T28D9.7   492 --RAWAEKMQSRQMK    504

GED: domain 1 of 1, from 567 to 606: score 5.8, E = 2.3
                   *->eelldeLLeEdpeias..kRkelkkrLelLkkArqiisev<-*
                      ++++++L  E +e as+++Rke  k+L+  kk+++++ +
     T28D9.7   567    RQKFEKLIVEMHECASgkMRKEAGKMLSSFKKSYRELQAA    606

ASC: domain 1 of 1, from 26 to 685: score 489.7, E = 2.3e-143
                   *->nrlrRafWlllvlvslglllwQigiliskYlskptvsvnielkfPve
                      +++++ +W+++++++++l+l+Q+++ i+ Y s+p v +nie ++P +
     T28D9.7    26    YSRYKGLWCMIIIAFVILVLVQCYSQIKLYISEP-VATNIEAEYP-S 70

                   klpFPaVTiCNlNPykyse........vrsn.ivlelndtldaftllely
                   k+ FP+V iCN+N++++ + ++++  ++rs++i+ +l+ t++ +++++++
     T28D9.7    71 KISFPTVAICNNNQFRLTYltggrimnRRSKsISGSLLSTGHDVESVFDT 120

                   sgs.ksemdalefnssrkrrskraqq.vrn.gks.lrg.rfplvfadcrl
                    ++++++mda++f++s++++++r++ ++++++++++++++f++v+++++l
     T28D9.7   121 VLRkSWDMDAVKFLRSAAHWKSRMILgCTWpNGTsCKLsDFKAVWTTTGL 170

                   dsqecv.deresrrtes..........lieipesvcicfgdrwkvgfwlC
                   ++++++++++++++t+s+++++ +   ++e++e+v++c++++++++++++
     T28D9.7   171 CWAINTdPHNPYEVTGSgeghglrlllNVESYERVDACTKHFRTKTLPGL 220

                   s.nstWekeCsCndhfCpcicsdlecvkttriweplykqsaepep.e.me
                   +   ++                                  ++++p+++m+
     T28D9.7   221 KiLIYN----------------------------------QTDIPdSsMN 236

                   tcedqgfssgtdevaewykakenlifaqaalseqfrislsysleeliltC
                     + ++ +s++++++++++ k+++++++++++eq ++s  ++ +e i tC
     T28D9.7   237 GVNVPSGYSMDIPFKMQHRSKLTGVHCIEENDEQIEASTDFNNPENIRTC 286

                   sF........ngesCdicrdFtt.fidpsyGnC...YtFNsnrstsiyrd
                   + ++  ++ +n+++C+ +r++t++ +d ++ +C+ + +F+++++++++++
     T28D9.7   287 TLrrymteveNSCHCTLRRAYTSnSTDVKMKACnvdQYFGCAQKAMQRIR 336

                   e.............genlltssrpGp.leyGLrlvLdvnqdeylPtteat
                   e+++ ++  ++ ++++++ ++ +   +++ + +l+   ++d+++++++++
     T28D9.7   337 EegtastclppcksIDYTAWQDMNRLpQNLMPALIEEQEEDDEDDVEQEE 386

                   pdalfetsfeaGvrvfiHeqdevPfpdsfGysappGfessigvklkqltr
                   +d+++++s++ G   f +e+++ P+++++ ++ ++ f        ++ tr
     T28D9.7   387 LDENVSFSTVSGGETFSCEDKSRPITSEEKKANQMFFLLDETAFNRNATR 436

                   Lp.v.elkapyGnCtedgedvpvenlYi........yiytnksYsieaCl
                   +++v++lk+ yG+ +e+ ++v+++++Yi++ +++ +++++  + + ++ l
     T28D9.7   437 YMsVgDLKSRYGDKMEKLWHVFMPDSYIrtmtgdfsRMDRIIELMNQYEL 486

                   rsCfqryivekCGCa.......dpryPlyesplngakyCtpekhidcgcc
                   +    r + ek++ ++ ++  +d +y +y++pl  + ++t +k+id+++
     T28D9.7   487 NKLQRRAWAEKMQSRqmkhffeDDFYESYYQPLIKDLDTTLVKQIDEVEA 536

                   ylklldtflqeklgak............sndfsvecqckCkqpCneteYt
                   ++ +  ++lq+++++k++     ++++++n++++e   + +++C + +++
     T28D9.7   537 DWPKVEYYLQRGSAGKtgaimffgdgnkDNRQKFEKLIVEMHECASGKMR 586

                   vtySyakwPSaased.........wlgpvlskfesekeendlyrnNiaml
                   ++++ + + +++s+++ +   ++ ++++  ++ e+ +  n+++++N+am+
     T28D9.7   587 KEAGKMLSSFKKSYRelqaaygklFKEELPDYLENFQFGNKFVGDNFAMV 636

                   nIffeeLnYesikEspaygvvnLLSdiGGqlGLflGaSVlsvlElielf<
                   nIf++++n e+++++++yg+++L +diGG+lGLflGaS+l+++E+++l+
     T28D9.7   637 NIFLHRMNLEVWSQDRTYGFWSLACDIGGALGLFLGASLLTIIEIVYLC  685

                   -*

     T28D9.7     -    -

SNase: domain 1 of 1, from 763 to 771: score 4.1, E = 7.6
                   *->kkrkGLWsd<-*
                      k+rk++W++
     T28D9.7   763    KRRKNIWAQ    771



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