Motif confirmation by HMMer
hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file: /home/niguts/usr02/tshini/ykclst/db/Pfam_fs
Sequence file: hmm5/seq/Y53F4B.28
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Query: Y53F4B.28 CE24422 locus:ptr-20 status:Partially_confirmed TR:Q9NAB5 protein_id:CAB61102.1
Scores for sequence family classification (score includes all domains):
Model Description Score E-value N
-------- ----------- ----- ------- ---
Patched Patched family 414.5 7.4e-126 2
DUF418 Protein of unknown function (DUF418) 3.3 8.9 1
Glycos_transf_4 Glycosyl transferase 2.7 9.7 1
Bcl-2 Apoptosis regulator proteins, Bcl-2 f 1.6 7 1
G6PD Glucose-6-phosphate dehydrogenase, NA 0.5 8.7 1
Parsed for domains:
Model Domain seq-f seq-t hmm-f hmm-t score E-value
-------- ------- ----- ----- ----- ----- ----- -------
Bcl-2 1/1 202 224 .. 1 24 [. 1.6 7
G6PD 1/1 414 419 .. 191 196 .] 0.5 8.7
Glycos_transf_4 1/1 459 492 .. 62 98 .. 2.7 9.7
Patched 1/2 79 573 .. 49 637 .. 228.7 2.9e-69
DUF418 1/1 699 738 .. 21 62 .. 3.3 8.9
Patched 2/2 676 856 .. 771 957 .] 183.5 1.7e-55
Alignments of top-scoring domains:
Bcl-2: domain 1 of 1, from 202 to 224: score 1.6, E = 7
*->LrraGdelekrveraFssmsrqlh<-*
r++++++e v+ +F s+s+ h
Y53F4B.28 202 -RALATDFENKVRAFFASISDLSH 224
G6PD: domain 1 of 1, from 414 to 419: score 0.5, E = 8.7
*->KEmVQN<-*
KE+V+N
Y53F4B.28 414 KELVKN 419
Glycos_transf_4: domain 1 of 1, from 459 to 492: score 2.7, E = 9.7
*->vvipflvlpflglevvlidLGllyillmvfllVgcsN<-*
v+i+fl+ p+ + ++ L +++++l+ ++lV+ N
Y53F4B.28 459 VFIDFLHTPVAK---LAVVLAFIGHILICLALVSHVN 492
Patched: domain 1 of 2, from 79 to 573: score 228.7, E = 2.9e-69
*->iitakarnsedytrpNiLdikyLnevvqvndfiltnvtipvsgalkk
+i ++ +n +NiL +L ev q +f+ n+t ++
Y53F4B.28 79 QILVSKKNR-----GNILTNEALGEVSQAHKFVADNITAFDGT---- 116
itlsfkdlCssfcdincpvnqhyngLdtlailrsnlhn...sridltYPt
+ +++k+lC +c+ n ++ la l+ l+++++s ++lt+P
Y53F4B.28 117 RHIAYKNLCGVYCN---DSNAAV-----LAFLQATLNDtsrSSFKLTFPN 158
mtffgtkiylgpnfgGVkldpgeNdvekllDsltklklvdtkseegniks
+ +ki++g +g+ k+++ g + +
Y53F4B.28 159 AEALQKKIFVGYSLGDLKIEK------------------------GYVTE 184
vkaivLyyrlkrdpeeveedskeWElsledyleneyk.sdshievtifsd
+k++vL y + + + + + ++E +++++++ ++ s+ hi+ ++ s
Y53F4B.28 185 AKMVVLHYMVDTSIPNGRALATDFENKVRAFFASISDlSH-HIKYSVLSR 233
qvledElvrngltlvPffvvgFaiLvtFsvltsvvlavrrsgslhidwvs
+ +E + +t Pf+ +++++L++F ++t v++ +
Y53F4B.28 234 TRELEEQRAITITSLPFLGLTIVVLTCFMLVTLVRFPL----------YT 273
sKpiLAilgvltPlmAivsAfGlLfwlGfrFnsIlcVmPFLVLGAIGVDD
s + +i gvl+P+mA ++ GlL +G +F++Il+V PFLV+ IG+DD
Y53F4B.28 274 SQHWQSIVGVLSPGMALWTTTGLLWGIGYPFSNILTVVPFLVV-TIGIDD 322
mFLMvhaWqrttrslssrarKvvkkRmgevlvEaGPSItITSlTnvLSFg
+FL+++ W++ t+ +s ++ R+g+ + +G S+t+TS+T+v F+
Y53F4B.28 323 AFLILAGWRQSTKGES------LEVRLGQSVAISGASVTVTSVTDVACFA 366
IGaiTptPeIqlFCiytavAiffdfiYQlTFFaAil..aiagkyEmkgrh
G ++ P +qlFC+yt vA++ dfiYQ+TFF+A+++ ++ ++++++
Y53F4B.28 367 TGLFSNMPVVQLFCLYTTVALAIDFIYQMTFFTALVgiFVRKQVDIEKEL 416
slflriTakavdaaetespkklkkqrlksrgsakaaPvekegeknSkfse
+ +++ +++ +++e+ + + + l+s++++
Y53F4B.28 417 VKNEP----KIEKTKEEEGASS--SSLASLLTFV---------------- 444
veesleseksssdssksheaeqktavvkfflniYcpfllnpkvrvcvllv
+++s+ea+ + +l+++ +fl +p+ +++v+l
Y53F4B.28 445 -------------PTISQEAHT-----RSILEVFIDFLHTPVAKLAVVLA 476
yvvYlaiaiYGctnlkegLdPskLllkDSpLveilrlrekhvwpyGsqvt
+++ + i+ +++ ++++d +L l+DSpL++i r+ ++v+ + + v+
Y53F4B.28 477 FIGHILICLALVSHVNTNFDMENLYLEDSPLTDISRRMQNFVLGEAFVVN 526
VvVNNPPDLtnpenrdrllemvdeFEntp.yalGkWEnsTkfWLrdYek<
V PD+ + r +++emv ++E++p+y Gk + T+ W r+Y +
Y53F4B.28 527 FGVYPMPDFDDEQIRLKFEEMVKSLETMPkYGAGK--ENTNLWIREYSN 573
-*
Y53F4B.28 - -
DUF418: domain 1 of 1, from 699 to 738: score 3.3, E = 8.9
*->wwvglllaliGlllnll.ivlysltlslnvsatlllqilrllG<-*
+++++ ++++ + +l+iv+y++++ n++a+ l+++l +G
Y53F4B.28 699 AIISV---AVSIVSICLgIVVYLHLWNVNLDAVSLISMLMSIG 738
Patched: domain 2 of 2, from 676 to 856: score 183.5, E = 1.7e-55
*->iQsiiwtlicMavVCflFIpnpitvfvitvsiaSIdiGVfGfLSLWG
i++ + ++++M++ ++FI n+ +++ ++vsi+SI++G++ +L LW+
Y53F4B.28 676 ISTSVSAVVLMSLLVLVFIMNFEAIISVAVSIVSICLGIVVYLHLWN 722
VdLDPisMitiIMSIGFSVDfsAHiaYhFyrskgsesrsikkiplktpde
V+LD++s i+++MSIGFSVD+sAH+ Yh+++ + + + +++
Y53F4B.28 723 VNLDAVSLISMLMSIGFSVDYSAHVCYHYFAHVHEDEQLWRSHNYAETRD 772
RvadALealGWPviQAalSTiLcvlvLlFVpsYmvvvFfKTifLVVvlGl
R+ ++ ++WPv Q +lSTiL++++L+FV +Y v vF KT++LV +lG+
Y53F4B.28 773 RLLSTFRGVAWPVMQSGLSTILGMFPLMFVRAYVVAVFWKTVILVGILGM 822
LHGLifLPilLslfvtssrifggdviirtsnakikkpseq<-*
LH+Li+LP++++l ++ ++++ r + a ++ p++
Y53F4B.28 823 LHALILLPVIFILTHD-IKLL-----FRRKRAVAPTPHSM 856