Motif confirmation by HMMer


hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /home/niguts/usr02/tshini/ykclst/db/Pfam_fs
Sequence file:            hmm5/seq/Y75B8A.24
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Query:  Y75B8A.24  CE23035   Phosphoinositide 3-kinase family, accessory domain (PIK domain) \; Phosphatidylinositol 3- and 4-kinases status:Parti

Scores for sequence family classification (score includes all domains):
Model           Description                             Score    E-value  N
--------        -----------                             -----    ------- ---
PI3_PI4_kinase  Phosphatidylinositol 3- and 4-kinase    237.9    1.4e-67   1
PI3Ka           Phosphoinositide 3-kinase family, acc    85.7    3.9e-24   1
eRF1_3          eRF1 domain 3                             6.7        2.4   1
ribonuclease_T2 Ribonuclease T2 family                    6.0        2.5   1
SseC            Secretion system effector C (SseC) li     2.2        4.3   1

Parsed for domains:
Model           Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------        ------- ----- -----    ----- -----      -----  -------
SseC              1/1    1112  1171 ..   424   491 .]     2.2      4.3
eRF1_3            1/1    1378  1395 ..     1    18 [.     6.7      2.4
PI3Ka             1/1    1619  1719 ..    78   192 ..    85.7  3.9e-24
PI3_PI4_kinase    1/1    1863  2070 ..     1   335 []   237.9  1.4e-67
ribonuclease_T2   1/1    2098  2116 ..   111   126 ..     6.0      2.5

Alignments of top-scoring domains:
SseC: domain 1 of 1, from 1112 to 1171: score 2.2, E = 4.3
                   *->AklekKiEqLitqqRvlDrlkeELsnmCqaeylQkvmEeLYKGsGAi
                      ++l + i+q+      +Drl    ++ C +    + mE+       +
   Y75B8A.24  1112    TTLSGDIDQVTAENQLIDRLEKDFQRACKSGKDME-MEQ-------A 1150

                   fqlisdkgdtlhnvnsRiasv<-*
                     l+ +    l ++n Ri s
   Y75B8A.24  1151 VLLLTALFVSLRSLNERILSL    1171

eRF1_3: domain 1 of 1, from 1378 to 1395: score 6.7, E = 2.4
                   *->iiqEkklieeFleeiakD<-*
                      + ++++l+ +F+e+++ D
   Y75B8A.24  1378    LREDIRLLTRFFEHLKND    1395

PI3Ka: domain 1 of 1, from 1619 to 1719: score 85.7, E = 3.9e-24
                   *->sLldkWvWqapidpvdALELLdpk.FadnheeVReYAVkcLesYasD
                      s+++ W   a  +pv AL+LL p  ++  h+   +YAV++L+s  s
   Y75B8A.24  1619    SHVLTW---ARCSPVMALSLLTPRiYPM-HPISMQYAVRVLRS-YSA 1660

                   dELlfYLLQLVQALKYEnldepfhdSpLsrFLlkRAlkNrsrlGHfFfWy
                   dELl+Y++Q+VQA++Y+       +++ s+++++ A  ++ +l+H+++W+
   Y75B8A.24  1661 DELLLYIPQIVQAVRYD------TMGYISELIIWLAGHSQ-LLSHQLIWN 1703

                   LksEiYKDdldhdeevkse<-*
                   + +++     d+++ vk++
   Y75B8A.24  1704 MQTNM---FTDEESKVKDP    1719

PI3_PI4_kinase: domain 1 of 1, from 1863 to 2070: score 237.9, E = 1.4e-67
                   *->gyafifKgGdDlrsrqDervlQliaVFKPkDEEPyAplNPkgtkwsh
                      ++a+ifK+GdD r  qD++ lQl
   Y75B8A.24  1863    WQAAIFKVGDDVR--QDMLALQLM----------------------- 1884

                   GerlmnkllkgegldrrRnlqltaYlviplgsrsGliewvpnattlaeip
                     +lm++++ g gl  r    + +Y+v+++++++G+ie+vpn+ + +++
   Y75B8A.24  1885 --QLMKNVWAGLGLPVR----VFPYRVVATSPGCGVIECVPNSKSRDQLG 1928

                   ptyvvkksfkpfnysdfmraklkttnqlsknakllkehkdllqmapdrkq
                   + +
   Y75B8A.24  1929 RQTD---------------------------------------------- 1932

                   ltllekvevFeealsntpkpgllqwFvkkfpdaapyeewfarfeeLtear
                                       gl+++F+ +++d+ + e++++       ar
   Y75B8A.24  1933 -------------------FGLYEYFKTQYGDE-SSETFQE-------AR 1955

                   knfvrScAgmsvldYiLgngDRHldNiLvkkdkktGklfHIDFGlcfphs
                   +nfvrS+A +sv+ ++L++ DRH++Ni++   + +G+++HIDFG++f+
   Y75B8A.24  1956 RNFVRSMAAYSVFSFLLQIKDRHNGNIMI---DLDGHIIHIDFGFMFE-- 2000

                   kgkrgekpervPFrLTrWPQaklpfveamggyiasLgpsgdeglFrelce
                    +++g+  +++ F+L        ++v  mgg      +   +  F +lc+
   Y75B8A.24  2001 SSPGGNLGFEPDFKLSE------EMVAIMGGK----MEAAPFRQFASLCV 2040

                   eayralRrnlnlltnlLkqkavarGllmledglpdwrs<-*
                   +ay+a+R ++ ++++l         +lml++ lp++r
   Y75B8A.24  2041 HAYLAVRPYHKSFVSLV--------SLMLDTHLPCFRG    2070

ribonuclease_T2: domain 1 of 1, from 2098 to 2116: score 6.0, E = 2.5
                   *->P.Cy.d.yselynqedYFe<-*
                      ++C+ +  s++y+q +YF+
   Y75B8A.24  2098    TnCFlNiRSKMYDQLQYFQ    2116



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