Motif confirmation by HMMer
hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file: /home/niguts/usr02/tshini/ykclst/db/Pfam_fs
Sequence file: hmm5/seq/Y75B8A.24
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Query: Y75B8A.24 CE23035 Phosphoinositide 3-kinase family, accessory domain (PIK domain) \; Phosphatidylinositol 3- and 4-kinases status:Parti
Scores for sequence family classification (score includes all domains):
Model Description Score E-value N
-------- ----------- ----- ------- ---
PI3_PI4_kinase Phosphatidylinositol 3- and 4-kinase 237.9 1.4e-67 1
PI3Ka Phosphoinositide 3-kinase family, acc 85.7 3.9e-24 1
eRF1_3 eRF1 domain 3 6.7 2.4 1
ribonuclease_T2 Ribonuclease T2 family 6.0 2.5 1
SseC Secretion system effector C (SseC) li 2.2 4.3 1
Parsed for domains:
Model Domain seq-f seq-t hmm-f hmm-t score E-value
-------- ------- ----- ----- ----- ----- ----- -------
SseC 1/1 1112 1171 .. 424 491 .] 2.2 4.3
eRF1_3 1/1 1378 1395 .. 1 18 [. 6.7 2.4
PI3Ka 1/1 1619 1719 .. 78 192 .. 85.7 3.9e-24
PI3_PI4_kinase 1/1 1863 2070 .. 1 335 [] 237.9 1.4e-67
ribonuclease_T2 1/1 2098 2116 .. 111 126 .. 6.0 2.5
Alignments of top-scoring domains:
SseC: domain 1 of 1, from 1112 to 1171: score 2.2, E = 4.3
*->AklekKiEqLitqqRvlDrlkeELsnmCqaeylQkvmEeLYKGsGAi
++l + i+q+ +Drl ++ C + + mE+ +
Y75B8A.24 1112 TTLSGDIDQVTAENQLIDRLEKDFQRACKSGKDME-MEQ-------A 1150
fqlisdkgdtlhnvnsRiasv<-*
l+ + l ++n Ri s
Y75B8A.24 1151 VLLLTALFVSLRSLNERILSL 1171
eRF1_3: domain 1 of 1, from 1378 to 1395: score 6.7, E = 2.4
*->iiqEkklieeFleeiakD<-*
+ ++++l+ +F+e+++ D
Y75B8A.24 1378 LREDIRLLTRFFEHLKND 1395
PI3Ka: domain 1 of 1, from 1619 to 1719: score 85.7, E = 3.9e-24
*->sLldkWvWqapidpvdALELLdpk.FadnheeVReYAVkcLesYasD
s+++ W a +pv AL+LL p ++ h+ +YAV++L+s s
Y75B8A.24 1619 SHVLTW---ARCSPVMALSLLTPRiYPM-HPISMQYAVRVLRS-YSA 1660
dELlfYLLQLVQALKYEnldepfhdSpLsrFLlkRAlkNrsrlGHfFfWy
dELl+Y++Q+VQA++Y+ +++ s+++++ A ++ +l+H+++W+
Y75B8A.24 1661 DELLLYIPQIVQAVRYD------TMGYISELIIWLAGHSQ-LLSHQLIWN 1703
LksEiYKDdldhdeevkse<-*
+ +++ d+++ vk++
Y75B8A.24 1704 MQTNM---FTDEESKVKDP 1719
PI3_PI4_kinase: domain 1 of 1, from 1863 to 2070: score 237.9, E = 1.4e-67
*->gyafifKgGdDlrsrqDervlQliaVFKPkDEEPyAplNPkgtkwsh
++a+ifK+GdD r qD++ lQl
Y75B8A.24 1863 WQAAIFKVGDDVR--QDMLALQLM----------------------- 1884
GerlmnkllkgegldrrRnlqltaYlviplgsrsGliewvpnattlaeip
+lm++++ g gl r + +Y+v+++++++G+ie+vpn+ + +++
Y75B8A.24 1885 --QLMKNVWAGLGLPVR----VFPYRVVATSPGCGVIECVPNSKSRDQLG 1928
ptyvvkksfkpfnysdfmraklkttnqlsknakllkehkdllqmapdrkq
+ +
Y75B8A.24 1929 RQTD---------------------------------------------- 1932
ltllekvevFeealsntpkpgllqwFvkkfpdaapyeewfarfeeLtear
gl+++F+ +++d+ + e++++ ar
Y75B8A.24 1933 -------------------FGLYEYFKTQYGDE-SSETFQE-------AR 1955
knfvrScAgmsvldYiLgngDRHldNiLvkkdkktGklfHIDFGlcfphs
+nfvrS+A +sv+ ++L++ DRH++Ni++ + +G+++HIDFG++f+
Y75B8A.24 1956 RNFVRSMAAYSVFSFLLQIKDRHNGNIMI---DLDGHIIHIDFGFMFE-- 2000
kgkrgekpervPFrLTrWPQaklpfveamggyiasLgpsgdeglFrelce
+++g+ +++ F+L ++v mgg + + F +lc+
Y75B8A.24 2001 SSPGGNLGFEPDFKLSE------EMVAIMGGK----MEAAPFRQFASLCV 2040
eayralRrnlnlltnlLkqkavarGllmledglpdwrs<-*
+ay+a+R ++ ++++l +lml++ lp++r
Y75B8A.24 2041 HAYLAVRPYHKSFVSLV--------SLMLDTHLPCFRG 2070
ribonuclease_T2: domain 1 of 1, from 2098 to 2116: score 6.0, E = 2.5
*->P.Cy.d.yselynqedYFe<-*
++C+ + s++y+q +YF+
Y75B8A.24 2098 TnCFlNiRSKMYDQLQYFQ 2116