Motif confirmation by HMMer
hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file: /home/niguts/usr02/tshini/ykclst/db/Pfam_fs
Sequence file: hmm5/seq/ZK1067.1
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Query: ZK1067.1 CE25678 locus:let-23 tyrosine-protein kinase (Epidermal growth factor receptor subfamily) status:Partially_confirmed TN:CAA938
Scores for sequence family classification (score includes all domains):
Model Description Score E-value N
-------- ----------- ----- ------- ---
Furin-like Furin-like cysteine rich region 325.2 1.4e-94 2
Recep_L_domain Receptor L domain 289.7 1.8e-86 2
pkinase Protein kinase domain 214.1 2.1e-60 1
ETX_MTX2 Clostridium epsilon toxin ETX/Bacillus 6.9 0.38 1
DX DX module 4.1 3.9 1
Parsed for domains:
Model Domain seq-f seq-t hmm-f hmm-t score E-value
-------- ------- ----- ----- ----- ----- ----- -------
Recep_L_domain 1/2 109 248 .. 1 154 [] 154.4 1.3e-45
Furin-like 1/2 251 413 .. 1 183 [] 328.0 2.1e-95
Recep_L_domain 2/2 428 546 .. 1 154 [] 140.2 2.6e-41
Furin-like 2/2 554 581 .. 1 46 [. 3.9 3.6
DX 1/1 704 722 .. 77 95 .. 4.1 3.9
pkinase 1/1 929 1194 .. 1 294 [] 214.1 2.1e-60
ETX_MTX2 1/1 1343 1363 .. 313 333 .] 6.9 0.38
Alignments of top-scoring domains:
Recep_L_domain: domain 1 of 2, from 109 to 248: score 154.4, E = 1.3e-45
*->nCtvIeGnLeItlrsengdpk..fsniedelel.ds.eledlssLsn
+C++++GnLeIt+++ n+++k ++s+++++++++++++l++ +++ n
ZK1067.1 109 GCRRVYGNLEITWIEANEIKKwrESTNSTVDPKnEDsPLKSINFFDN 155
ieeItGyLlIyrtpgnlvslsfLpNLrvIrGrnlfdgsntenyalvildN
+eeI+G+L+Iyr + + +p+LrvI+G++ f+ +al+i+ N
ZK1067.1 156 LEEIRGSLIIYRA---NIQKISFPRLRVIYGDEVFH-----DNALYIHKN 197
pnltksssGLqeLglpsLkeItskGgvyihnNpHPkLCyteteidwflit
++ e +++L++I++ G+v i++Np k+Cy +idw+ ++
ZK1067.1 198 DK-------VHEVVMRELRVIRN-GSVTIQDNP--KMCYIGDKIDWKELL 237
rknaeqkidid<-*
++ + qk++++
ZK1067.1 238 YDPDVQKVETT 248
Furin-like: domain 1 of 2, from 251 to 413: score 328.0, E = 2.1e-95
*->ereCpdNGKSmAvChGTleakGesCkkttiNGefdyRCWGsgpedCQ
+++C++NGKSmA+Ch esC+ ++ CWGsg++dCQ
ZK1067.1 251 HQHCYQNGKSMAKCH-------ESCN-DK--------CWGSGDNDCQ 281
klTKlvCpsqCsgrrCtgpnptdSYECCHeeCaGGCTGPrdPtdClACRh
+++++vCp++Cs +C+++n+t+SYECC+++C+GGCTG+++ ++C+AC++
ZK1067.1 282 RVYRSVCPKSCS--QCFYSNSTSSYECCDSACLGGCTGHGP-KNCIACSK 328
FyddGiCketCPpptyynedTrqvdfNPegkYqfGasCVkeCPsnylvth
+++dGiC+etCP+++++n++T++++fNP+g+Yq+G++CVkeCP+++l++
ZK1067.1 329 YELDGICIETCPSRKIFNHKTGRLVFNPDGRYQNGNHCVKECPPELLIE- 377
nGsCvrsCPsgktevgaesGvreCekCeG.pCPKvCe<-*
n++Cvr+C++g++++++++ vreCekC++++CPK+C+
ZK1067.1 378 NDVCVRHCSDGHHYDATKD-VRECEKCRSsSCPKICT 413
Recep_L_domain: domain 2 of 2, from 428 to 546: score 140.2, E = 2.6e-41
*->nCtvIeGnLeItlrsengdpkfsniedeleldseledlssLsnieeI
+C++I+G+L+I+ +++ e+l++L++++ +
ZK1067.1 428 GCEQIDGHLIIEHAFTY------------------EQLKVLETVKIV 456
tGyLlIyrtpgnlvslsfLpNLrvIrGrnlfdgsntenyalvildNpnlt
++y++I + n+ +l+fL+NL++I+Gr+l++ ++al+i+++++
ZK1067.1 457 SEYITIVQQ--NFYDLKFLKNLQIIEGRKLHNV----RWALAIYQCDD-- 498
ksssGLqeLglpsLkeItskGgvyihnNpHPkLCyteteidwflitrkna
L+eL l sLk I + G v i +N+ +LCy+ idw++i+++
ZK1067.1 499 -----LEELSLNSLKLIKT-GAVLIMKNH--RLCYVSK-IDWSSIITSKG 539
eqkidid<-*
+++ +
ZK1067.1 540 KDNKPSL 546
Furin-like: domain 2 of 2, from 554 to 581: score 3.9, E = 3.6
*->ereCpdNGKSmAvChGTleakGesCkkttiNGefdyRCWGsgpedC<
++ C vC+ +C+k + CWG pedC
ZK1067.1 554 SKLCET---EQRVCD-------KNCNKRG--------CWGKEPEDC 581
-*
ZK1067.1 - -
DX: domain 1 of 1, from 704 to 722: score 4.1, E = 3.9
*->CgsGlirDnVCVkknleka<-*
C ++++ nVCV +l+ +
ZK1067.1 704 CLQSSGMNNVCVENDLPNY 722
pkinase: domain 1 of 1, from 929 to 1194: score 214.1, E = 2.1e-60
*->yelleklGeGsfGkVykakhkd....ktgkiVAvKilkkekesikek
+l +klG+G+fG+V+ +++ +++ ++ + +VA+K++ + ++++e
ZK1067.1 929 TKLDKKLGAGAFGTVFAGIYYPkrakNVKIPVAIKVFQTDQSQTDE- 974
rflrEiqilkrLsHpNIvrligvfedtddhlylvmEymegGdLfdylrrn
+l E+ + rL+H+N++++ig+++ +dd l +v+ y + G L ++l+ +
ZK1067.1 975 -MLEEATNMFRLRHDNLLKIIGFCM-HDDGLKIVTIYRPLGNLQNFLKLH 1022
ggplsekeakkialQilrGleYLHsngivHRDLKpeNILldendgtvKia
+ +l+ +e + +++Qi++G++YL+ +++vHRDL+++N+L+++ ++v i+
ZK1067.1 1023 KENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKF-NHVEIT 1071
DFGLArlle...sssklttfvGTpwYmmAPEvilegrgysskvDvWSlGv
DFGL++ l+++ +s + +++ + + A E+ + y++++DvW++Gv
ZK1067.1 1072 DFGLSKILKhdaDSITIKSGKVAIKWL-AIEI-FSKHCYTHASDVWAFGV 1119
iLyElltggplfpgadlpaftggdevdqliifvlklPfsdelpktridpl
+++E+ t g ++P+++ + +
ZK1067.1 1120 TCWEIITFG-------------------------QSPYQG-------MST 1137
eelfriikrpglrlplpsncSeelkdLlkkcLnkDPskRpG....satak
+ +++ +k+ g rl +p+ncS +l++ l +c+ DP++RpG + + +k
ZK1067.1 1138 DSIHNFLKD-GNRLSQPPNCSQDLYQELLRCWMADPKSRPGfeilYERFK 1186
eilnhpwf<-*
e ++ p +
ZK1067.1 1187 EFCKVPQL 1194
ETX_MTX2: domain 1 of 1, from 1343 to 1363: score 6.9, E = 0.38
*->kkikskdsevvkiesleisak<-*
k ++s ++e+v +e+ e+s k
ZK1067.1 1343 KPETSEEAEAVQYENEEVSQK 1363