Motif confirmation by HMMer
hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file: /home/niguts/usr02/tshini/ykclst/db/Pfam_fs
Sequence file: hmm5a/seq/ZK632.12
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Query: ZK632.12 CE01110 PH (pleckstrin homology) domain status:Confirmed SW:P34657 protein_id:CAA80187.1
Scores for sequence family classification (score includes all domains):
Model Description Score E-value N
-------- ----------- ----- ------- ---
FYVE FYVE zinc finger 118.9 3.8e-32 1
PH PH domain 59.1 2.9e-15 1
zf-Dof Dof domain, zinc finger 5.9 2.5 1
P53 P53 4.5 2.8 1
Parsed for domains:
Model Domain seq-f seq-t hmm-f hmm-t score E-value
-------- ------- ----- ----- ----- ----- ----- -------
PH 1/1 36 131 .. 1 85 [] 59.1 2.9e-15
zf-Dof 1/1 143 180 .. 1 38 [. 5.9 2.5
FYVE 1/1 147 213 .. 1 72 [] 118.9 3.8e-32
P53 1/1 218 239 .. 418 440 .] 4.5 2.8
Alignments of top-scoring domains:
PH: domain 1 of 1, from 36 to 131: score 59.1, E = 2.9e-15
*->vikeGwLlkks.kswkkRyfvLfndvLlyykdsk....kkpkgsipL
++ eG L k+ +k+ k+R f+Lfnd L+y +++++++++++ L
ZK632.12 36 LVGEGVLVKMCrKKPKQRQFFLFNDILVYGNIVIskkrYNKQRILRL 82
sgcqvek.pd....kncFeirt.drtlllqaeseeerkeWvkaiqsair<
+g+qve+ +d++ +k+++ i+t+ +++ + a++e e++eW+ +i++++
ZK632.12 83 EGVQVEDlEDdgieKHGWIIKTpAKSFAVYAATETEKREWMLHIERCVT 131
-*
ZK632.12 - -
zf-Dof: domain 1 of 1, from 143 to 180: score 5.9, E = 2.5
*->kpeealkcpRCdstntKFCYynnYslsqPRyfCkaCrR<-*
+++a+ +p ++ + C ++l q R+ C++C R
ZK632.12 143 TAHAAVWVPDGEAVKCMVCGKTQFNLVQRRHHCRNCGR 180
FYVE: domain 1 of 1, from 147 to 213: score 118.9, E = 3.8e-32
*->phWvpDeevsnCmrCgkpFtkltkRrHHCRaCGrifCgsCssktvll
++WvpD e+ +Cm+Cgk++++l++RrHHCR+CGr++Cg Css+t+++
ZK632.12 147 AVWVPDGEAVKCMVCGKTQFNLVQRRHHCRNCGRVVCGACSSRTFRI 193
pylgiaaliekpvRVCdsCydrlnk<-*
++ + +kpvRVCd+C+d+l+
ZK632.12 194 DNVH-----KKPVRVCDHCFDSLSS 213
P53: domain 1 of 1, from 218 to 239: score 4.5, E = 2.8
*->degpspSkgKKlmvkdekgpDSd<-*
+e+++p+ g++l+ d+ +DS+
ZK632.12 218 QEESEPKTGNRLHHEDS-SSDSE 239